tbuckley/cabot-search huggingface dataset:
New prostate cancer drugs: few CV effects?
Authors: J. Henahan
Journal: JAMA (1983)

Encouraging alternative approaches to orchiectomy and estrogen therapy for advanced prostatic cancer were highlighted in a series of presentations at the recent XIIIth International Congress of Chemotherapy in Vienna. Among the most prevalent malignant neoplasms worldwide, prostate cancer may be difficult to treat because it has often metastasized to bone and other organs by the time of diagnosis. One new investigational approach involves the use of synthetic analogs of gonadotropin-releasing hormone (GnRH), while the other employs drugs designed to destroy prostatic tumor tissue selectively. Most of the synthetic GnRH agents now under study result from substitution of a different amino acid in the 6 position of the naturally occurring GnRH decapeptide. Unlike natural GnRH, which is released in pulsatile fashion from the hypothalamus and acts through the pituitary to ultimately stimulate testosterone production by the gonads, the synthetic agonists apparently occupy the pituitary GnRH receptors continuously, desensitizing them and thereby
CATTLE AND CANCER.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Food, Skin Allergies Have Increased in US Children
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEW
Authors: W. C. EHMANN
Journal: JNCI Journal of the National Cancer Institute (1993)

BOOK REVIEW Get access AIDS and Other Manifestations of HIV Infection, 2nd Edition Gary P. Wormser , ed . New York : Raven Press , 1992 . 715 pp., illus. $130. ISBN 0-88167-881-3 W. CHRISTOPHER EHMANN, M.D. W. CHRISTOPHER EHMANN, M.D. Milton F. Hershey Medical Center, Department of Medicine/Hematology DivisionP.O. Box 850, Hershey, PA 17033 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 8, 21 April 1993, Pages 670–671, https://doi.org/10.1093/jnci/85.8.670 Published: 21 April 1993
Medical licensure statistics for 1970
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bioequivalence of Levothyroxine Preparations: Issues of Science, Publication, and Advertising-Reply
Authors: Richard M. Glass
Journal: JAMA (1997)

<h3>In Reply.</h3> —Dr Lankin and Mr Birnbaum raise concerns regarding the appearance of advertisements for levothyroxine from Jones Medical Industries in the same issue as the study by Dong et al and raise questions about the policies and procedures ofThe Journalwith respect to the relationship between editorial and advertising content and functions. The AMA publications follow specific principles governing advertising,<sup>1</sup>which include eligibility requirements, specific policies for pharmaceutical advertising, guidelines for price comparison advertising, and standards for advertising copy. The scientific journals, the editorial staff, and the advertising sales force also adhere to the standards for advertisements set forth by the International Committee of Medical Journal Editors,<sup>2</sup>which stipulate that advertising must not influence editorial decisions, juxtaposition of editorial and advertising material on the same product or subject is avoided, and advertising is not sold on the condition that it will appear in the same issue as a
Angioedema
Authors: Allen P. Kaplan
Journal: New England Journal of Medicine (1984)

Recurrent angioedema is a particularly vexing problem for patients and clinicians alike, because over 90 per cent of chronic cases are "idiopathic" and therapy is often only palliative. Nevertheless, considerable information is available regarding several clinical entities that may be similar, including allergic or idiosyncratic reactions to foods or medication, hereditary angioedema, physically induced swelling, and angioedema in association with underlying connective-tissue disease or tumor (chiefly lymphoma).1 The four cases described by Gleich et al.2 in this issue most likely represent a new entity with potentially important implications for studies directed toward an understanding of the mechanisms of angioedema.Although . . .
THE ORIGINATOR OF THE STOMACH TUBE.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lifetime and 12-Month Prevalence of DSM-III-R Disorders in the Chile Psychiatric Prevalence Study
Authors: Benjamin Vicente
Journal: American Journal of Psychiatry (2006)

Objective: Although several epidemiological studies of the prevalence of psychiatric disorders have been conducted in Latin America, few of them were national studies that could be used to develop region-wide estimates. Data are presented on the prevalence of DSM-III-R disorders, demographic correlates, comorbidity, and service utilization in a nationally representative adult sample from Chile. Method: The Composite International Diagnostic Interview was administered to a stratified random sample of 2,978 individuals from four provinces representative of the country’s population age 15 and older. Lifetime and 12-month prevalence rates were estimated. Results: Approximately one-third (31.5%) of the population had a lifetime psychiatric disorder, and 22.2% had a disorder in the past 12 months. The most common lifetime psychiatric disorders were agoraphobia (11.1%), social phobia (10.2%), simple phobia (9.8%), major depressive disorder (9.2%), and alcohol dependence (6.4%). Of those with a 12-month prevalence diagnosis, 30.1% had a comorbid psychiatric disorder. The majority of those with comorbidity had sought out mental health services, in contrast to one-quarter of those with a single disorder. Conclusions: The prevalence rates in Chile are similar to those obtained in other studies conducted in Latin America and Spanish-speaking North American groups. Comorbidity and alcohol use disorders, however, were not as prevalent as in North America.
Erratum
Journal: BMJ (1891)

deatlh-rate during the same period in the large English towns.The higlhest zymotic death-rates wer-e r-ecor ded in Aberdeen, Perth.and Greenock.The 1A9 deaths registered in Glasgow included 12 from diarrhmea, 8 from imeasles, 6 from scarlet fever, and 5 from " fever."The death-rate from diseases of the respiratory organs in these towns was.equal to 2.6 per 1,000, against 2.1 inl LondoIln.HEALTII OF IRISH TOWNS.
Erratum: Apology
Authors: James D. McCawley
Journal: Behavioral and Brain Sciences (1990)

In my comments on David Lightfoot in BBS (INFL,/Spec, and other fabulous beasts, 1989, 12:350–52) regarding language learnability, the symbol for verb was incorrectly printed as Y, rather than V. The error appeared at the end of the first paragraph in the second column on page 351. The clause should have read: “…the approach allows a child to learn rules of syntactic structure in terms of whatever category components he can so far identify (hence prior to the acquisition of the full repertoire of category notions) and it allows him to impose specific syntactic structures on sentence types whose syntax and semantics he has not yet learned (even a child who did not yet understand passive sentences would assimilate was given money to the already learned [V', VV'] surface configuration as soon as he had identified was as a V').”
Abdomino-Pelvic Diagnosis in Women.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errata
Journal: Journal of Clinical Oncology (2017)

contained an error.Under Recommendations in the Bottom Line section, based on the findings of the trial conducted by the Gruppo Italiano Mammella investigators, which demonstrated improved disease-free survival and overall survival observed with four cycles of epirubicin 90 mg/m 2 and cyclophosphamide 600 mg/m 2 followed by four cycles of paclitaxel 175 mg/m 2 delivered every two weeks (dose-dense EC-P) compared to every 3 weeks, the guideline adaptation should have included the dose-dense EC-P regimen, as provided below, in the list of acceptable adjuvant chemotherapy regimens for patients with higher-risk early breast cancer.Dose-dense epirubicin 90 mg/m 2 , cyclophosphamide 600 mg/m 2 every 2 weeks 4 cycles → paclitaxel 175 mg/m 2 every 2 weeks for 4 cycles.
Abstract 5077: Metastasis suppressors regulate the tumor microenvironment by blocking recruitment of pro-metastatic TAMs
Authors: Daniel C. Rabe, Casey Frankenberger, Russell Bainer, Devipriya Sankarasharma, Kiran Chada, Thomas Krausz, Yoav Gilad, Lev Becker, Marsha R. Rosner
Journal: Cancer Research (2015)

Abstract Triple-negative breast cancer (TNBC) patients have the highest risk of recurrence and metastasis. Because they cannot be treated with targeted therapies, and many do not respond to chemotherapy, they represent a clinically underserved group. While physiological inhibitors of metastasis (metastasis suppressors) play key roles in regulating tumor growth, invasion and metastasis, their role in regulating the tumor microenvironment and immune system is unknown. We hypothesized that the metastasis suppressor Raf Kinase Inhibitory Protein (RKIP) regulates stromal cells, which then affect tumor invasiveness. Using species-specific RNAseq we determined that expression of RKIP in tumors markedly reduces the number and metastatic potential of infiltrating TAMs. While TAMs isolated from TNBC xenografts drive in vitro invasion, RKIP+ derived TAMs did not drive invasion and had decreased secretion of pro-metastatic factors including SLPI, OPN, MMP-12, Galectin-3, VEGF-A, VEGF-D, TNFR2, and PGRN. We determined that RKIP regulates TAM recruitment by blocking HMGA2, which activates CCL5 expression. CCL5 rescued TAM infiltration as well as tumor intravasation. We additionally showed that factors decreased in RKIP-derived TAMs were restored in CCL5-derived TAMs. Finally, we demonstrated the TAM secreted factor PGRN is both necessary and sufficient for TAM driven invasiveness. To determine the clinical utility of these TAM genes we combined their expression with RKIP signaling in the tumor to create a signature that strikingly separates TNBC patients based on outcome. Our results demonstrate for the first time that metastasis suppressors can regulate the microenvironment, regulating invasion through TAMs. Our results also suggest TNBC patients with decreased RKIP activity and increased TAM infiltration may respond to therapies targeting CCL5 or PGRN. Citation Format: Daniel C. Rabe, Casey Frankenberger, Russell Bainer, Devipriya Sankarasharma, Kiran Chada, Thomas Krausz, Yoav Gilad, Lev Becker, Marsha R. Rosner. Metastasis suppressors regulate the tumor microenvironment by blocking recruitment of pro-metastatic TAMs. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5077. doi:10.1158/1538-7445.AM2015-5077
Effect of Cold Environment on Experimental Atherosclerosis in the Rabbit
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asthma
Authors: J. F. Riera-Fanego, M. Wells, D. K. Luyt, M. Dance, J. Piva, S. Amantéa, A. Rosso, S. Zambonato, K. Giugno, T. Maia, G. J. Browne, A. Penna, X. Phung, M. Soo, R. C. Wetzel, Maged Z. Youssef, Peter Silver, Laura Nimkoff, Mayer Sagy, V. J. Wang, N. R. Patel, Ç. J. L. Newth
Journal: Intensive Care Medicine (1996)
Infective endocarditis. Olmsted County, Minnesota, 1950 through 1981
Authors: M. R. Griffin
Journal: JAMA (1985)

Strict criteria were used to identify all definite, probable, and possible cases of endocarditis in residents of Olmsted County, Minnesota, from 1950 through 1981. The mean annual age- and sex-adjusted incidence rates per 100,000 person-years were 3.8 for total cases and 3.2 for definite and probable cases only. Total rates were 4.3 for 1950 through 1959, 3.3 for 1960 through 1969, and 3.9 for 1970 through 1981. Rheumatic heart disease was the underlying disorder in 26% of cases, with a shift noted during 1970 through 1981 to involvement of prosthetic rather than natural valves in these patients. Mitral valve prolapse was identified in 17% of cases. No source of infection could be identified in 41% of cases, including half of those cases with rheumatic or congenital heart disease. In cases diagnosed prior to autopsy, the 60-day fatality fell from 46% during 1950 through 1959 to 22% and 26% during 1960 through 1969 and 1970 through 1981, respectively. (<i>JAMA</i>1985;254:1199-1202)
The Lumleian Lectures on some Problems in Connection with Aphasia and Other Speech Defects: Delivered before the Royal College of Physicians, April 8th, 1897
Authors: H. C. Bastian
Journal: BMJ (1897)

duction was in excess.There was a saccular bulging in the postero- superior wall of the canal, and caseous and cholesteatomatous matter was present in the inner end of canal, projecting from the attic of the tympanum.She came to the Ear Hospital complaining of alarming attacks of giddiness, along with great pain and constant buzzing in the affected ear.For a fortnight the giddiness had been so severe that she could not go out of doors, and she was in constant fear of falling.Even in bed she felt as if "tossing in a boat."When walking she was inclined to stagger to the affeted side, and sudden motion of the head brought on these staggerings.One day while lifting a kettle from the fire she was impelled to wheel round, so that she fell on to the fire.Eight weeks previous to her coming to the hospital the giddiness was attended by severe sickness and vomiting, the attack lasting for several days.The caseous and cholesteatomatous matter was removed,and the ear was sub- jected to careful and prolonged antiseptic treatment, with the result that the painful symptoms passed quickly off, the giddiness subsiding more gradually.In May last she reported herself as having been quite free from the giddiness for a long time.The hearing was still very defective, and there was still slight discharge necessitating the occasional use of the syringe..The simple exudative catarrhs of the middle ear without perforation of the tympanic membrane do not so frequently excite giddiness as the more acute purulent forms.Occa- sionally, however, we find striking exceptions, such as in the following case:Giddine8s and Sickne8s due to Simple Exudative Catarrh of Middle Ear.-Recently I had under my care a waiter from Perth, a man 40 years of age, who after a nasal cata.rrhbecame very deaf in both ears.with the develop- ment of subjective sounds in the ear, compared to that of blowiDg off steam.When these symptoms had continued for two weeks or there- abouts he began to have severe attacks of giddiness.On the way to consult me at the Glasgow Ear Hospital he had an alarming seizure in the street.He then became suddenly so giddy as to stagger and fall, fol- lowed immediately by si.kness and vomiting; he had to be assisted into a place of shelter.l found on examination syiiiptoms of exudative catarrh in both middle ears, which were occupied by a considerable amount of secretion, but without perforation.The deafness was extreme in both ears, while distressing subjective sounds were constantly present.I incised both tympanic membranes, giving exit to a large quantity of muco-serous secretion, with the result of effecting an instantaneous and marked improvement in the hearing.The giddiness also almost imme- diately disappeared and did not return.The use of Politzer's method of inflation for a few weeks restored entirely the hearing power This patient informed me that he was " subject to biliousness and had a bad liver."
Immunologic aspects of diseases of the eye
Authors: C. E. Reed
Journal: JAMA (1982)

THE EYE may be the target of allergic inflammation in a variety of systemic immunologic conditions. Ocular signs and symptoms can often be the most striking and disabling aspects of such diseases. The eye is also affected by several local conditions in which immunologic mechanisms are thought to play a significant role. Major structures of the eye are illustrated in Fig 12-1. Immunologically mediated diseases of the skin and mucous membranes, the cornea, and the uveal tract and retina are discussed in the following sections. <h3>DISEASES OF THE SKIN AND MUCOUS MEMBRANES OF THE EYE</h3><h3>Contact Sensitivity</h3> Contact sensitivity is a common condition seen in the practice of ophthalmology. Several commonly used topical ophthalmic preparations are offenders. The patient may experience itching, tearing, and sensitivity to light. The eyelids are at first erythematous and indurated but, with long-term exposure to the agent, scaling and lichenification occur (Fig 12-2). In general,