tbuckley/cabot-search huggingface dataset:
Grand Rounds
Authors: Martha Leslie
Journal: Annals of Internal Medicine (1996)

Ad Libitum1 August 1996Grand RoundsMartha Leslie, MDMartha Leslie, MDStanford University Clinic Palo Alto, CA 94304-2205Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-3-199608010-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Women I notice that weare by far minorityin this room full of menwith white hairand good mannersYet I do not feel challengedto be more than these men areinspired despite knowledgeof inevitable fallibilityand human fragilitythe caprice of Providenceto be reckoned with in mornings and evenings and nightsalonegentle in passing wounded soulswho have lost the arroganceof perceived immortalitydaring a glint of laughter in the eyespark of protection against eventualityearly light for the bonfire of hopeequally requiredby men with white hairand good mannersand challengers to fate'sharsher standards Author, Article, and Disclosure InformationAffiliations: Stanford University Clinic Palo Alto, CA 94304-2205Corresponding Author: Martha Leslie, MD, Department of Medicine, Stanford University Clinic, 900 Blake Wilbur Drive, Suite W2080, Palo Alto, CA 94304-2205. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1996Volume 125, Issue 3Page: 204 ePublished: 15 August 2000 Issue Published: 1 August 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Radical Surgery
Authors: Danely P. Slaughter
Journal: JAMA (1965)

The perennial flare-up between radiotherapists and surgeons in relation to the use of either method in the treatment of neoplastic disease has, in recent years, led not only to more confusion, but, at the same time, to some clarification of our concepts of the entity called Hodgkin's disease. The recent literature is such a welter of contradictions, scattered misquotes, and almost vituperative protagonism, that the author is tempted to confine his references and bibliography to Lewis Carroll's<i>Alice in Wonderland</i>. To paraphrase: "The time has come," the walrus said, "To talk of Sternberg cells, Of nodes—and drugs and surgery, Of death—and tolling bells. And why these points are boiling hot And whether rays make well." The current renewed interest in Hodgkin's disease is due to two observations: (1) that the course of the disease can be modified greatly by the use of alkylating agents and other forms of chemotherapy, and
Impact of Chronic Graft Versus Host Disease (cGVHD) on the Health Status of Hematopoietic Cell Transplantation (HCT) Survivors: A Report from the Bone Marrow Transplant Survivor Study.
Authors: Christopher Fraser, Smita Bhatia, Kirsten Ness, Andrea Carter, Liton Francisco, Mukta Arora, Pablo Parker, Stephen Forman, Daniel Weisdorf, James Gurney, K. Scott Baker
Journal: Blood (2005)
Consultant Discontent
Authors: P. F. Boreham, D. H. K. Soltau, J. Fairgrieve, T. P. Ormerod, S. E. Trickey, D. L. Stevens, R. D. G. Creery, A. B. Dew, P. J. Briers, K. Ll. Owen, S. Haynes, R. E. Davis, A. S. Jackson, M. M. Hills, N. M. C. Mayne, D. S. Thomson, F. A. Hanna, D. J. Mahy, R. J. Hart, L. Henry, E. M. Edwards, C. T. Hart, A. F. Hamilton, J. A. P. Evans, N. R. Garden, T. I. Cash, J. S. Miller, W. M. Lennox, R. H. Coates, G. C. Fox
Journal: BMJ (1974)
'Sudden Death' —A Search Through Eight Generations
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medico-legal mishaps.
Journal: BMJ (1965)

New Test for Thyrotoxicosis?In most patients with thyrotoxicosis the diagnosis can be made on clinical grounds alone.'In almost all the remaining patients in whom the diagnosis is more difficult the results of radioiodine (13'I) studies and determinations of proteinbound stable iodine (P.B.1271I) in the serum are adequate guides to the diagnosis.These considerations are rather less true, however, when thyrotoxicosis is suspected during pregnancy.In normal pregnancy complaints of tiredness, palpitation, dyspnoea, and intolerance to heat are not uncommon, and when these symptoms are associated with hot, moist hands, tachycardia, 'Crooks,
Fatalities Associated With Harvesting of Sea Urchins—Maine, 1993
Journal: JAMA (1994)

During 1992-1993, six persons died while diving for sea urchins in Maine waters--two during 1992 and four during August-November 1993. The four 1993 deaths were investigated by the Maine Department of Marine Resources, the U.S. Coast Guard, the Office of the Chief Medical Examiner in Maine, and the Occupational Safety and Health Administration (OSHA); each of the deaths was attributed to drowning. This report describes the results of the investigations of these cases.
Support for health-science libraries
Authors: N. Q. Brill
Journal: JAMA (1965)

Critical deficiencies exist in the area of medical communications, especially in medical libraries. Within recent years these defects have been documented very adequately by numerous groups, including the American Medical Association; the Association of American Medical Colleges; the President's Commission on Heart Disease, Cancer and Stroke; the Medical Library Association; and the National Library of Medicine, among others. There seems to be firm agreement that the deficiencies go considerably beyond the frustrations of the medical-school librarian who insists that his budget is too small, or the complaints of the students, teachers, or practitioners who cannot find particular articles they desire. The consensus seems to be that failure to meet the needs of the health-science libraries could indirectly threaten the health efforts of the entire nation. <h3>Pending Legislation</h3> On Jan 19, 1965, Senator Lister Hill and Representative Oren Harris introduced in the Senate and House, respectively, the medical library assistance act
LECTURES.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Body mass index and mortality among nonsmoking older persons. The Framingham Heart Study
Authors: T. Harris
Journal: JAMA (1988)

The relationship of weight at age 65 years and subsequent mortality was examined in a population of 1723 nonsmokers who were followed up from one to 23 years (mean, 9.5 years) during the Framingham Heart Study. In sex-specific proportional hazards analyses, risks of mortality were increased for men and women at the high and low extremes of body mass index, even when accounting for potential effects of excess weight on serum cholesterol level, blood glucose level, and systolic blood pressure. For those at the lower extreme of body mass index, the relative risk of death was almost twice as high in the years immediately after age 65 years as in later follow-up, suggesting that the increased early death rate was due to disease that was already present. At the upper extreme, risk of death was twofold over the entire follow-up period for persons with body mass indexes at or above the 70th percentile at both 55 and 65 years of age. We conclude that, even when accounting for cardiovascular risk factors, being overweight is a serious health problem for older people, especially for those with long-standing weight problems. (<i>JAMA</i>1988;259:1520-1524)
MRE11-RAD50-NBS1 COMPLEX INHIBITOR MIRIN ENHANCES RADIOSENSITIVITY IN HUMAN GLIOBLASTOMA CELLS
Authors: K. Mishima, M. Mishima-Kaneko, T. Kawata, H. Saya, N. Ishimaru, K. Yamada, R. Nishikawa, N. Shigematsu
Journal: Neuro-Oncology (2014)

BACKGROUND: (blind field) METHODS: Glioma cell lines (U251, LN229 and LN428) were irradiated with and without Mirin and then clonogenicity, apoptosis, and cell cycle change were examined. Western blot analysis was performed to determine the relative potency of Mirin to inhibit the radioresistance, through the signaling activity of AKT. We also examined the levels of H2AX phosphorylation (γH2AX), which is a marker of DNA double-strand breaks (DSBs) using Western blot. RESULTS: Glioblastoma cells pretreated with Mirin demonstrated an enhanced sensitivity to radiation. FACS analysis revealed that Mirin and radiation caused the glioma cells to accumulate in the G2/M-phase of the cell cycle and the combination of these two treatments further increased the G2/M fraction of the glioma cells. Mirin significantly enhanced radiation-induced apoptotic cell death. Also, Mirin blocked the basal and increase of radiation-induced AKT phosphorylation. We observed that the combination of Mirin and radiation increased persistence of γH2AX at 24 h suggesting the inhibition of DNA DSBs repair. CONCLUSIONS: These results indicate that Mirin can effectively enhance glioma cell radiosensitivity. It suggests that Mirin is a potent radiosensitizer for treating glioma cells. SECONDARY CATEGORY: n/a.
Incorrect References
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuromeningeal Localizations of Acute Leukemias and their Treatment by Intraspinal Injections of Amethopterin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subcutaneous panniculitis by Epstein‐Barr virus‐infected natural killer (NK) cell proliferation terminating in aggressive subcutaneous NK cell lymphoma
Authors: Yasunobu Abe, Koichiro Muta, Koichi Ohshima, Shinichiro Yasumoto, Motoaki Shiratsuchi, Ryoko Saito, Jun Tsujita, Tomoko Shibata, Masutaka Furue, Masahiro Kikuchi, Junji Nishimura, Hajime Nawata
Journal: American Journal of Hematology (2000)

We describe here a case involving a patient presenting initially with subcutaneous panniculitis, which developed after 12 years into aggressive subcutaneous natural killer (NK) cell lymphoma with peripheral blood involvement and hemophagocytosis. The surface marker of lymphoid cells in peripheral blood was CD2+3–7+8–16+56+. Skin biopsies were taken in May 1986 and June 1998. The initial biopsy revealed a diffuse proliferation of atypical lymphoid cells in the subcutaneous tissue with panniculitis, while the second biopsy revealed the presence of large lymphoid cells in the subcutaneous tissue with necrotic changes, consistent with a diagnosis of malignant lymphoma (diffuse pleomorphic type). The lymphoid cells from these two specimens were positive for CD56 and such cytotoxic molecules as T-cell intracellular antigen-1 (TIA-1), granzyme B, and, interestingly, also positive for Epstein-Barr (EB) virus by in situ hybridization. This suggests that chronic EB virus infections play an important role in the early stages of tumorigenesis and in the progression of NK cell lymphoproliferative disorders. Am. J. Hematol. 64:221–225, 2000. © 2000 Wiley-Liss, Inc.
A Novel P-Selectin Glycoprotein Ligand-1 Monoclonal Antibody Recognizes an Epitope Within the Tyrosine Sulfate Motif of Human PSGL-1 and Blocks Recognition of Both P- and L-Selectin
Authors: Karen R. Snapp, Han Ding, Kristin Atkins, Roger Warnke, Francis W. Luscinskas, Geoffrey S. Kansas
Journal: Blood (1998)
(43) Widespread pigmented purpuric eruption
Authors: R. H. Meyrick Thomas, D. D. Munro
Journal: British Journal of Dermatology (1983)

Journal Article (43) Widespread pigmented purpuric eruption Get access R. H. Meyrick Thomas, R. H. Meyrick Thomas Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE Search for other works by this author on: Oxford Academic Google Scholar D. D. Munro D. D. Munro Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 109, Issue s24, 1 July 1983, Page 99, https://doi.org/10.1111/j.1365-2133.1983.tb11650.x Published: 01 July 1983
A 79-year-old musician with asymptomatic carotid artery disease
Authors: L. R. Caplan
Journal: JAMA (1995)

Dr DALEY: Mr C, a 79-year-old married professional classical musician with a history of cardiovascular and peripheral vascular disease, was noted to have asymptomatic carotid bruits in March 1995. He is active as a teacher and performer. He is insured by Medicare and carries supplemental Medigap insurance. In 1989, Mr C underwent coronary artery bypass grafting for progressive anginal symptoms. Angina recurred in December 1994, and cardiac catheterization revealed diffuse three-vessel coronary artery disease with patent grafts. In recent months his angina has abated with medical therapy. His risk factors for atherosclerosis include a total cholesterol level of 6.18 mmol/L (239 mg/dL), a family history of coronary artery disease, and a history of smoking cigarettes 20 years ago. Current medications include amlodipine besylate, 5 mg daily; terazosin hydrochloride, 5 mg daily, for mild symptoms of prostatic hypertrophy; and one enteric coated aspirin daily. Hypercholesterolemia is managed by diet, although until
Developmental Programming: Differential Effects of Prenatal Testosterone Excess on Insulin Target Tissues
Authors: Shadia E. Nada, Robert C. Thompson, Vasantha Padmanabhan
Journal: Endocrine Reviews (2010)

Polycystic ovarian syndrome (PCOS) is the leading cause of infertility in reproductive-aged women with the majority manifesting insulin resistance. To delineate the causes of insulin resistance in women with PCOS, we determined changes in the mRNA expression of insulin receptor (IR) isoforms and members of its signaling pathway in tissues of adult control (n = 7) and prenatal testosterone (T)-treated (n = 6) sheep (100 mg/kg twice a week from d 30-90 of gestation), the reproductive/metabolic characteristics of which are similar to women with PCOS. Findings revealed that prenatal T excess reduced (P &amp;lt; 0.05) expression of IR-B isoform (only isoform detected), insulin receptor substrate-2 (IRS-2), protein kinase B (AKt), peroxisome proliferator-activated receptor-γ (PPARγ), hormone-sensitive lipase (HSL), and mammalian target of rapamycin (mTOR) but increased expression of rapamycin-insensitive companion of mTOR (rictor), and eukaryotic initiation factor 4E (eIF4E) in the liver. Prenatal T excess increased (P &amp;lt; 0.05) the IR-A to IR-B isoform ratio and expression of IRS-1, glycogen synthase kinase-3α and -β (GSK-3α and -β), and rictor while reducing ERK1 in muscle. In the adipose tissue, prenatal T excess increased the expression of IRS-2, phosphatidylinositol 3-kinase (PI3K), PPARγ, and mTOR mRNAs. These findings provide evidence that prenatal T excess modulates in a tissue-specific manner the expression levels of several genes involved in mediating insulin action. These changes are consistent with the hypothesis that prenatal T excess disrupts the insulin sensitivity of peripheral tissues, with liver and muscle being insulin resistant and adipose tissue insulin sensitive.
Acute Calculous Cholecystitis
Authors: Patricia Adams
Journal: New England Journal of Medicine (2008)

ion, including an assessment of the impact of the Internet.Especially thought provoking is Mark Cherry's consideration of the implications of adopting paid organ donation as public health policy.Living Donor Organ Transplantation has much to recommend it.Its publication is timely, since the bylaws regulating UNOS living donation, requested by the Department of Health and Human Services, were adopted in September 2007.An excellent compendium of the state of transplantation from living donors, this book will be a valuable resource for the national network, transplant centers, referring physicians, and potential living donors.The composite bibliography from many noted transplant professionals is a treasure.Readers will save a lot of time searching in PubMed with this reference on their shelves.
Non-small cell lung cancer and estrogen plus progestin use in postmenopausal women in the Women's Health Initiative randomized clinical trial
Authors: R. T. Chlebowski, A. Schwartz, H. Wakelee, G. L. Anderson, M. L. Stefanick, J. E. Manson, J. W. Chien, C. Chen, J. Wactawski-Wende, M. Gass
Journal: Journal of Clinical Oncology (2009)

CRA1500 Background: Sex differences in lung cancer outcome suggest a potential hormonal influence; however, observational studies provide mixed findings regarding menopausal hormone therapy (HT) and lung cancer. Methods: Secondary analyses of the WHI randomized, placebo-controlled trial of daily conjugated equine estrogen (CEE, 0.625 mg) plus medroxyprogesterone acetate (MPA, 2.5 mg) in 16,608 multi-ethnic postmenopausal women, aged 50–79 were conducted on lung cancer incidence and mortality. Lung cancers were confirmed by medical record review. Results: Groups were balanced for age, race/ethnicity, and prior HT. Smoking status was also comparable (never 50%, past 40%, current 10% in both groups). Cumulative risk for lung cancer was highest in current (0.51%), compared to past (0.14%) and never (0.04%) smokers. After 5.6 years on trial intervention and 2.4 years additional follow-up (median), small cell lung cancer incidence was comparable between randomization groups (total n=26), as was subsequent small cell lung cancer mortality. Although a trend for more non-small cell lung cancer (NSCLC) diagnoses in the active hormone group was not significant (p=0.12), an apparent divergence emerged after five years, with more diagnoses in the CEE+MPA group. In addition, mortality after NSCLC diagnosis was significantly higher for the CEE+MPA group (46.3% vs 27.0%, respectively, hazard ratio (HR) 1.59, 95% CI 1.03–2.46, p=0.04). As a result, CEE+MPA group women were more likely to die from NSCLC than those on placebo (p=0.02). Conclusions: Use of CEE + MPA for over 5 years increases a woman's risk for NSCLC mortality, the leading cause of cancer death in women. These data, together with recent results indicating higher breast cancer risk (Cancer Res 2009;69(2):78s), suggest cancer impact should influence risk-to-benefit consideration for combined HT use. NSCLC outcomes (annualized %) by randomization group CEE+MPA Placebo HR 95% CI P-Value N % N % NSCLC Incidence 96 0.14% 72 0.11% 1.28 0.94, 1.73 0.12 NSCLC Mortality * 67 0.10% 39 0.06% 1.61 1.09–2.39 0.02 * Analyses begin at entry randomization Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Amgen, AstraZeneca, Eli Lilly, Novartis, Wyeth Amgen, AstraZeneca, Eli Lilly, Novartis, Wyeth Amgen