tbuckley/cabot-search huggingface dataset:
Notfallchirurgie: Die Ausführung der dringlichen blutigen Eingriffe
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radionuclide imaging in intrascrotal lesions
Authors: N. S. Datta
Journal: JAMA (1975)

Twenty-three patients with a variety of intrascrotal lesions were studied by means of imaging after the intravenous injection of sodium pertechnetate Tc 99m. The features of the radionuclide image correlated well with the clinical course or findings at surgical exploration or both. The conditions in which this technique was helpful in diagnosis included testicular torsion, acute inflammatory lesions, abscess, and hematoma. (<i>JAMA</i>231:1060-1062, 1975)
Abstract 4682: TGFB signaling disruption in the formation of oral pre-neoplasia
Authors: Claudia D. Andl, Anna L. Means, James S. Lewis, Alexandra Rothaus, Thomas Andl
Journal: Cancer Research (2019)

Abstract In humans, tissue homeostasis has to be maintained for decades without significant loss of functionality. Epithelia such as the oral mucosa achieve this through the self-renewing capabilities of stem cells. These life-long residents of the oral mucosa maintain homeostasis of the epithelium and at the same time have to be able to protect themselves from the main threats to longevity, i.e., stem cell exhaustion and malignant conversion and carcinogenesis. A key pathway in mediating cell cycle arrest in oral keratinocytes is mediated by TGFB superfamily signaling. There is good evidence implicating TGFB signaling as a tumor suppressor pathway in oral cancer. We have previously shown that disruption of TGFB signaling and cell adhesion can lead to oral squamous cell carcinoma. In vitro using oral keratinocytes, we found that TGFB regulates the stem cell compartment, inducing gene expression of quiescent stem cell markers MECP2, XPC, ITGB1 and PDPN. Using multiplex immunofluorescence, we have stained a tissue microarray containing 28 cases of squamous cell carcinoma, 4 adenocarcinoma, 4 metastatic carcinoma, 6 hyperplasia, and 5 adjacent inflammatory as well as normal adjacent and normal tissues. The antibodies selected were MECP2, XPC, ITGB1 and K15 in combination with the proliferation marker ki67 to determine if TGFB signaling regulates markers of stem cell quiescence. This quiescent gene signature highlighted a basal niche for slow-cycling cells, reserve stem cells. During oral disease progression, marker expression was abandoned in favor of increased proliferation. In vivo, a mouse model in which KrasG12D expression was induced and the Smad4 gene deleted specifically in the adult epithelium showed invasive cancers in the oral cavity. These Smad4-negative tumors express Sox9, a marker of human OSCCs and a TGFB target, which we have also observed to be upregulated in human premalignant lesions. Sox9-positive areas in the mouse tumors are associated with a downregulation of quiescent oral stem cell markers Krt15 and Mecp2, same as we observed in immunostainings of human tissues. In conclusion, TGFB and SMAD4 regulate quiescent stem cells and loss of this pathways allows invasive cancers to develop in the setting of oncogene expression. Furthermore, we could show that MECP2 in combination with other markers identifies quiescent basal cells in the human oral mucosa and is lost as TGFB signaling is disrupted in tumorigenesis. Citation Format: Claudia D. Andl, Anna L. Means, James S. Lewis, Alexandra Rothaus, Thomas Andl. TGFB signaling disruption in the formation of oral pre-neoplasia [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4682.
Silver Chloride In Whooping-cough.—
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Chronic Fatigue Syndrome
Authors: Jonathan Rest
Journal: Annals of Internal Medicine (1995)

Letters1 July 1995The Chronic Fatigue SyndromeJonathan Rest, MDJonathan Rest, MDUniversity of California, San Francisco; San Francisco, CA 94122Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-1-199507010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The development of an effective new case definition for the chronic fatigue syndrome poses a unique challenge because of the protean nature of fatigue and its accompanying symptoms. Unfortunately, the 1988 case definition failed to identify a unique disease entity (Hickie and colleagues; Reyes and colleagues. Unpublished data). Although the case criteria suggested by Fukuda and colleagues [1] address many of the shortcomings of the 1988 research definition, the clinical and social need for a definitive diagnostic tool remains largely unmet.Although the previous research case definition was a significant step forward, its clinical implications were unanticipated. ...REFERENCE1. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A, and the International Chronic Fatigue Syndrome Study Group. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994; 121:953-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, San Francisco; San Francisco, CA 94122 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1995Volume 123, Issue 1Page: 74-76KeywordsChronic fatigue syndromeClinical epidemiologyFatiguePatients ePublished: 15 August 2000 Issue Published: 1 July 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
High plasma concentration of myeloperoxidase in cirrhosis: A possible marker of hypersplenism
Authors: M Nakamuta
Journal: Hepatology (1993)

Plasma myeloperoxidase levels in patients with cirrhosis were compared with those in patients with chronic hepatitis and healthy controls by means of a specific radioimmunoassay for myeloperoxidase. The mean concentration of plasma myeloperoxidase in cirrhotic patients (309.1 ± 17.2 ng/ml, n = 41) was markedly higher than that in chronic hepatitis patients (222.6 ± 17.2 ng/ml, n = 21) (p < 0.01) and normal controls (219.5 ± 5.7 ng/ml, n = 50) (p < 0.01). Plasma myeloperoxidase showed good negative correlations with neutrocyte count (r = −0.32, p < 0.01), thrombocyte count (r = −0.40, p < 0.01), red blood cell count (r = −0.32, p < 0.01), serum albumin (r = −0.35, p < 0.01), and cholinesterase (r = −0.32, p < 0.02) and positive correlations with serum alkaline phosphatase (r = 0.49; p < 0.01) and lactate dehydrogenase (r = 0.31, p < 0.01) in patients with cirrhosis or chronic hepatitis. Among lactate dehydrogenase isozymes, a good positive correlation was seen between plasma myeloperoxidase and lactate dehydrogenase-2 (r = 0.40, p < 0.01) and lactate dehydrogenase-1 (r = 0.03, p < 0.02). Plasma myeloperoxidase was significantly higher in the cirrhotic and chronic hepatitis patients with splenomegaly (341.1 ± 19.4 ng/ml, n = 31) than in those without splenomegaly (217.4 ± 12.2 ng/ml, n = 29) (p < 0.01). We also examined the difference between plasma levels of myeloperoxidase in the portal and peripheral blood. In the patients with nonhepatic disease, we found a significant portalsystemic difference (portal myeloperoxidase, 221.5 ± 19.7 ng/ml, vs. systemic myeloperoxidase, 179.1 ± 10.8 ng/ml; n = 15) (p < 0.01), whereas there was no such difference in the cirrhotic patients (portal myeloperoxidase, 281.5 ± 15.2 ng/ml vs. systemic myeloperoxidase, 268.0 ± 28.2 ng/ml; n = 7). A significantly high concentration of plasma myeloperoxidase was evident in the case of esophageal varices, which is a sign of portalsystemic shunting in human beings. The results of our study imply that the release of myeloperoxidase from destroyed neutrocytes, in addition to its decreased hepatic clearance, are responsible for the high concentrations of plasma myeloperoxidase in cirrhotic patients. Therefore measurement of plasma myeloperoxidase may be useful in assessing hypersplenic function in liver disease. (HEPATOLOGY 1993;18:1377–1383.)
Hypovolemic Shock
Authors: William Schumer
Journal: JAMA (1979)

A 65-YEAR-OLD man is admitted to the emergency department with a two-day history of melena associated with dizziness and light-headedness. The skin is pale, cold, and clammy. The radial pulse is thready and small at 130 beats per minute. The patient is dyspneic with a respiratory rate of 24/min, and the blood pressure (BP) is 110/60 mm Hg. As the examination progresses, the patient becomes agitated, and circumoral cyanosis appears. The mucous membranes become dry, the BP decreases to 80/40 mm Hg, and the pulse rate increases to 150 beats per minute. A nasogastric tube is inserted, and it elicits bright red blood. This is a description of hypovolemic or hemorrhagic shock, probably secondary to upper gastrointestinal hemorrhage. Shock is defined as inadequate circulating blood volume with decreasing peripheral vascular perfusion ultimately causing cellular metabolic derangements. The volume loss from a bleeding gastric or duodenal ulcer stimulates pressure receptors in
COMPARISON OF XENON-133 VENTILATION AND AEROSOL INHALATION IMAGING USING A NEW COMMERCIAL GENERATOR SYSTEM IN PULMONARY EMBOLISM (PE).
Authors: Lalitha Ramanna, Alan D. Waxman, Mary E. Chappel, Michael B. Brachman, Doina E. Tanasescu, Daniel S. Berman
Journal: Clinical Nuclear Medicine (1983)

Ramanna, Lalitha; Waxman, Alan D.; Chappel, Mary E.; Brachman, Michael B.; Tanasescu, Doina E.; Berman, Daniel S. Author Information
Functional Lecithin: Cholesterol Acyltransferase Is Not Required for Efficient Atheroprotection in Humans
Authors: Laura Calabresi, Damiano Baldassarre, Samuela Castelnuovo, Paola Conca, Letizia Bocchi, Chiara Candini, Beatrice Frigerio, Mauro Amato, Cesare R. Sirtori, Paola Alessandrini, Marcello Arca, Giuliano Boscutti, Luigi Cattin, Loreto Gesualdo, Tiziana Sampietro, Gaetano Vaudo, Fabrizio Veglia, Sebastiano Calandra, Guido Franceschini
Journal: Circulation (2009)

Background— Mutations in the LCAT gene cause lecithin:cholesterol acyltransferase (LCAT) deficiency, a very rare metabolic disorder with 2 hypoalphalipoproteinemia syndromes: classic familial LCAT deficiency (Online Mendelian Inheritance in Man No. 245900), characterized by complete lack of enzyme activity, and fish-eye disease (Online Mendelian Inheritance in Man No. 136120), with a partially defective enzyme. Theoretically, hypoalphalipoproteinemia cases with LCAT deficiency should be at increased cardiovascular risk because of high-density lipoprotein deficiency and defective reverse cholesterol transport. Methods and Results— The extent of preclinical atherosclerosis was assessed in 40 carriers of LCAT gene mutations from 13 Italian families and 80 healthy controls by measuring carotid intima-media thickness (IMT). The average and maximum IMT values in the carriers were 0.07 and 0.21 mm smaller than in controls ( P =0.0003 and P =0.0027), respectively. Moreover, the inheritance of a mutated LCAT genotype had a remarkable gene-dose–dependent effect in reducing carotid IMT ( P =0.0003 for average IMT; P =0.001 for maximum IMT). Finally, no significant difference in carotid IMT was found between carriers of LCAT gene mutations that cause total or partial LCAT deficiency (ie, familial LCAT deficiency or fish-eye disease). Conclusions— Genetically determined low LCAT activity in Italian families is not associated with enhanced preclinical atherosclerosis despite low high-density lipoprotein cholesterol levels. This finding challenges the notion that LCAT is required for effective atheroprotection and suggests that elevating LCAT expression or activity is not a promising therapeutic strategy to reduce cardiovascular risk.
Written care plan and patient enablement: Pre-implementation data from the 4R in Oncology Project.
Authors: Julia Rachel Trosman, Christine B. Weldon, Claudia B. Perez, Swati Kulkarni, Seema Ahsan Khan, Nora Hansen, Valerie Nelson, Jennifer Stein, Melissa A. Simon, Jonathan Blake Strauss, Al Bowen Benson, Sasa M. Espino, Mikele Bunce, Wayne Pan, Sarah M. Friedewald, William John Gradishar
Journal: Journal of Clinical Oncology (2017)

e18032 Background: The IOM ’11 and ’13 reports recommend a written care plan (WCP) at cancer diagnosisto enable teamwork and patient (pt) engagement. Standardized multimodality WCP is a key part of the 4R model of care planning and pt engagement proposed under “NCI ASCO Teams” Project (Trosman JOP 2016). 4R (Right Information / Care / Patient / Time) is under implementation at 3 centers: academic, community and safety net. As current state assessment prior to implementing 4R and standard multimodality WCP, we surveyed pts not impacted by 4R on care planning, enablement and whether they received any WCP. Methods: Survey of breast cancer stage I-III pts who received care at the three sites Jan ’15 - Mar ’16, prior to 4R. We used simple frequencies and Fisher’s exact test in analysis. Results: Survey response rate: 47%, 241/515. Gaps of &gt; 30% were reported in 7 of 8 aspects of care planning and pt enablement - Table. A non standard WCP was received by 46% of pts. Receiving a WCP impacted whether pts were clear about care (85% with WCP vs 52% without, p &lt; .0001), able to manage own care (79% with WCP vs 58% without, p = .0005) and overwhelmed (35% with WCP vs 49% without, p = .04). Care complexity was a significant factor for feeling overwhelmed by pts without WCP (49% of pts receiving &gt; 6 care services felt overwhelmed vs. 30% of pts receiving &lt; = 6 services, p = .04), but not a significant factor in pts with WCP (45% vs 41%, p = .7). More pts with WCP reported well managed care by providers than pts without WCP (77%, 62%, P = .02). Conclusions: Serious gaps found in care planning and pt enablement at our sites support the need for 4R implementation. Even pre-4R, non standard WCPs improve pt understanding of care and ability to manage it, and reduce the impact of care complexity on pts. Providers using WCP appear to also coordinate care, but WCP itself may be an important factor of patient enablement. [Table: see text]
Clinical Usefulness of Hydrogen Gas as Indicator of Left-to-Right Shunting
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract LB-100: HNF4G overexpression promotes PDAC progression and confers metformin sensitivity in patients with SMAD4-loss of function
Authors: Chengcheng Wang, Chen Wu, Dongxin Lin, Yupei Zhao
Journal: Cancer Research (2019)

Abstract BACKGROUND: Genome-wide association studies (GWAS) have identified several genetic regions associated with risk of pancreatic ductal adenocarcinoma (PDAC) while the underlying mechanisms remain largely unknown. This study investigated the functions of genes in these genetic regions and their roles as potential biomarkers or therapeutic targets for PDAC. METHODS: We reanalyzed our previous GWAS data based on referring the 108 risk loci reported in published PDAC GWAS to seek for all susceptibility genes in the Chinese population and found 44 potential risk genes. A siRNA library was used to silence these genes in PDAC cell lines and the malignant phenotypes were examined by using a high content screen method followed by a series of functional assays. RESULTS: Among the 44 genes, HNF4G was the top one who’s silencing significantly repressed PDAC cell migration and invasion. Functional assays showed that HNF4G regulates cell-cell junction pathway, which may be the underlying mechanism for its action. HNF4G was upregulated by SMAD4 loss of function and frequently overexpressed in PDACs. PDAC cell metastasis promoted by the overexpression of HNF4G could be suppressed by metformin, and this effect was seen only in PDAC cells with SMAD4 loss of function, resulting in heterogeneous vulnerability of PDAC to the drug. CONCLUSION: HNF4G overexpression might result in metformin sensitivity in PDAC with SMAD4 loss of function and thus represent as a potential therapeutic target. Citation Format: Chengcheng Wang, Chen Wu, Dongxin Lin, Yupei Zhao. HNF4G overexpression promotes PDAC progression and confers metformin sensitivity in patients with SMAD4-loss of function [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-100.
Penicillin in Subacute Bacterial Endocarditis
Authors: R. V. Christie
Journal: BMJ (1949)

PENICILLIN IN SUBACUTE BACTERIAL ENDOCARDITISDBRrr s conciliatory; you will reject useful advice and friendly assistance; you will lose your sense of objectivity.In the group which I am called upon to direct, atmosphere is every- thing.We are all harnessed to one common cause, and everyone furthers it to the best of his strength and ability.Frequently we cannot distinguish what is mine and what is thine, but through this our common cause only gains."Thirdly, passion.Remember, science requires your whole life.Even if you had two lives to give it would still not be enough.Science demands of man effort and supreme passion.
Les séquelles de l'encéphalite épidémique: Etude clinique et thérapeutique.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of two dosages of ragweed extract in the treatment of pollenosis
Authors: W. Franklin
Journal: JAMA (1967)

A double-blind study was carried out to determine the effect of dosage in the treatment of ragweed hay fever with injections of aqueous ragweed pollen extract. Two concentrations of extract were used, one 20-fold smaller than the other. The volumes administered were such that the dose at the higher concentration was close to the maximum that it is practical to administer. During the ragweed season, the group of patients receiving the higher concentration fared significantly better than the group receiving the lower concentration. It is concluded that large dosages of pollen extract are more effective than small dosages in the treatment of hay fever. The findings indicate that the very low dosages recommended by some would have little influence on the course of pollenosis.