tbuckley/cabot-search huggingface dataset:
The office measurement of cholesterol
Authors: G. J. Boerma
Journal: JAMA (1989)

<h3>In Reply. —</h3> We appreciate Dr Boerma's comments, since they provide an opportunity to address an important nonanalytic issue about cholesterol variability. The statement that blood treated with edetic acid is inappropriate for testing on the Reflotron is incorrect. While the Reflotron is designed for analysis of whole blood, plasma or serum is a suitable specimen. According to the manufacturer, either heparin or edetic acid can be used as an anticoagulant. Dr Boerma points out that we have used the term<i>analytic range</i>in two different ways. It is essential that clinicians recognize that a method may not be linear over the complete analytic range claimed by the manufacturer. Finally, Dr Boerma raises the important distinction between analytic variability and biologic variability. This issue has recently been reviewed.<sup>1</sup>Biologic variability refers to the range of cholesterol values that one person manifests over time, even when diet, drugs, and other
Clinical features of never smoker patients with lung squamous cell carcinoma: A retrospective multicenter study
Authors: S. Frega, M. Macerelli, A. Del Conte, L. Bonanno, M. Bartoletti, V. Polo, G. Zago, A. Follador, I. Attili, A. Pavan, L. Urso, S.M.M. Basso, G. Fasola, P.F. Conte, G. Pasello
Journal: Annals of Oncology (2017)
CORRECTION
Journal: American Journal of Psychiatry (2018)

History of, prevention of, and response to school violence;• Helping and supporting students as they fail and are dismissed from college, graduate school, or medical school (managing shame, suicidality, debt, a new life path); • Stigma reduction and increasing help-seeking behavior;• Unique challenges to providing psychotherapy with college students; • The role of the psychiatrist or clinician in screening for and providing recommendations for accommodations for psychiatric and psychological disabilities; and • The complexities of effectively diagnosing attention deficit hyperactivity disorder in those who have been intelligent enough to compensate while maintaining appropriate protocol to prevent misuse and diversion of stimulant medication.
Genetic Engineering
Authors: Edmund F. Kal
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In his recent articles inThe Journal(220:1346,1480,1972), Dr. Ramsey objects on ethical grounds to genetic experimentation and "test tube babies." As much as I share his basic concerns,<sup>1</sup>I must disagree with the rigidity of his positions for, followed to their logical conclusions, they lead to a reductio ad absurdum. In his first article he argues thus: an accepted principle of medical ethics is<i>primum non nocere</i>, but in genetic experimentations in vitro we cannot guarantee a priori that there shall be no harm to the as yet unconceived person. Furthermore, it is an equally accepted principle of medical ethics that the subject experimented upon must give informed consent to accept the risks involved, which an unconceived person cannot possibly give. Ergo, all in vitro genetic experimentations with human subjects are ipso facto unethical, and should be stopped forthwith. In his second article he adds,
Marrow Iron
Authors: Ralph O. Wallerstein
Journal: JAMA (1977)

Marrow aspirates stained with the Prussian blue reaction give a variety of patterns. Characteristic pictures are shown for megaloblastic anemia, infection, and subjects after injection of iron dextran. The appearance of iron in histiocytes in marrows stained with Wright's stain is differentiated from noniron deposits. A graph shows the relative distribution of iron in RBCs and storage in different clinical situations. (<i>JAMA</i>238:1661-1662, 1977)
Thrombotic thrombocytopenic purpura. Concomitant occurrence in husband and wife
Authors: C. G. Watson
Journal: JAMA (1971)

The etiology of thrombotic thrombocytopenic purpura (TTP) remains obscure. Rickettsial organisms have recently been described in the peripheral blood of one patient with TTP and of two patients with the hemolytic uremic syndrome. The concomitant occurrence of TTP in two siblings has been reported. The concurrence of this disease in husband and wife, reported herein, further suggests an etiology of environmental origin.
Wigs.
Authors: M. J. Cheesbrough
Journal: BMJ (1989)

Wigs were originally popularised in Britain by Queen Elizabeth I, who is said to have owned no fewer than 80, and Mary Queen of Scots is reputed to have worn one at her execution.Louis XIII of France went prematurely bald in 1624 and by disguising his baldness with a wig, started a fashion that lasted over 150 years.In the seventeenth century the grandest wigs were worn by the wealthy and important, hence the expression "big wigs."The demand for wigs was so great that children were forbidden to go out alone in case thieves cut off their hair.Today five types of wigs are worn: necessity wigs to cover baldness, fashion or fun wigs, legal wigs, wigs worn for religious reasons, and theatrical wigs.Necessity and fun wigs merely differ in their indications for use.A variety offibres are used in their construction, but the commonest material is acrylic, which makes high quality and fairly cheap wigs.
Direct Extravascular Brain Cooling in the Normothermic Animal
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transmission of Hepatitis B Virus Among Persons Undergoing Blood Glucose Monitoring in Long-Term-Care Facilities--Mississippi, North Carolina, and Los Angeles County, California, 2003-2004
Journal: JAMA (2005)

Regular monitoring of blood glucose levels is an important component of routine diabetes care. Capillary blood is typically sampled with the use of a fingerstick device and tested with a portable glucometer. Because of outbreaks of hepatitis B virus (HBV) infections associated with glucose monitoring, CDC and the Food and Drug Administration (FDA) have recommended since 1990 that fingerstick devices be restricted to individual use. This report describes three recent outbreaks of HBV infection among residents in long-term-care (LTC) facilities that were attributed to shared devices and other breaks in infection-control practices related to blood glucose monitoring. Findings from these investigations and previous reports suggest that recommendations concerning standard precautions and the reuse of fingerstick devices have not been adhered to or enforced consistently in LTC settings. The findings underscore the need for education, training, adherence to standard precautions, and specific infection-control recommendations targeting diabetes-care procedures in LTC settings.
Abstract 124: Chronic Beta-Adrenergic Stimulation Prevents Protective Insulin-Induced Increases in Cardiomyocyte Respiratory Capacity
Authors: Jessica Pfleger, Jessica Ibetti, Walter J Koch
Journal: Circulation Research (2017)

Cardiac injury or stress increases circulating catecholamines (CA), stimulating cardiac β adrenergic receptors (βAR) and adaptive positive inotropy. Under such conditions of increased energy demand, cardiomyocyte metabolism and bioenergetics are altered to maintain cellular function and survival. During chronic CA stimulation, however, receptor desensitization occurs, contributing to loss of contractile reserve and heart failure (HF) development. This progression to HF is again marked by metabolic and bioenergetic changes that remain incompletely understood. Notably, chronic CA exposure induces insulin resistance (IR) in the heart, which decreases substrate uptake and prevents protective signaling. Our laboratory has shown that G protein-coupled receptor kinase 2 induces IR in the heart following myocardial infarction. However, neither the molecular mechanisms of CA-induced IR, nor its effects on cardiomyocyte bioenergetics are well characterized. We hypothesize that βAR stimulation induces IR by decreasing insulin-stimulated mitochondrial respiratory capacity, thus, compromising cardiomyocyte survival during stress. Bioenergetics were evaluated by measuring cellular respiration under coupled (basal) and uncoupled (maximal) conditions. Our results show that acute insulin treatment selectively increases (25%) maximal and reserve respiratory capacity in the presence of glucose, which positively correlates with cellular survival. This effect is completely inhibited with chronic βAR stimulation using isoproterenol or clenbuterol, as is glucose transporter (GLUT4) translocation to the membrane. A similar effect is reproduced by high glucose and/or palmitate-induced IR. Notably, chronic βAR stimulation does not affect basal or maximal respiration, while acute stimulation increases basal respiration (25%). In short, the data demonstrate a unique insulin-induced increase in mitochondrial respiratory capacity in cardiomyocytes that is antagonized by chronic CA stimulation. We propose that this effect contributes to the detrimental effects of βAR stimulation during HF. Thus, understanding this phenomenon and its mechanisms is critical for inhibiting IR and improving cardiac metabolism and function during HF.
Continuing Education Opportunities for Physicians
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OA05.06 Compliance and Outcome of Elderly Patients Treated in the Concurrent Once-Daily versus Twice-Daily RadioTherapy (CONVERT) Trial
Authors: Marianna Christodoulou, Fiona Blackhall, Linda Ashcroft, Ahmet Leylek, Joost Knegjens, Vincent Remouchamps, Isabelle Martel-Lafay, Núria Farré, Matjaz Zwitter, Delphine Lerouge, Nicolas Pourel, Henri Janicot, Arnaud Scherpereel, Caroline Tissing-Tan, Karine Peignaux, Xavier Geets, Krzysztof Konopa, Corinne Faivre-Finn
Journal: Journal of Thoracic Oncology (2017)
Preventing necrotizing enterocolitis in neonates
Authors: E. G. Brown
Journal: JAMA (1978)

Necrotizing enterocolitis of newborn infants virtually vanished from our nurseries during the four years since the introduction of a slowly progressive feeding regimen. This cautious approach to feeding has been applied to selected infants whose condition during labor and delivery or whose neonatal problems indicate that they are at risk. (<i>JAMA</i>240:2452-2454, 1978)
Spinal manipulation and mobilisation for back and neck pain.
Authors: R. S. MacDonald
Journal: BMJ (1992)

maintain operation of the system.-When a system is considered.Credit in this section should be given looked by the authors.Although almost identical upgraded it provides additional features that for the authors stating prospectively a small number criteria were used, it scored 38 on one occasion and require the original cost-benefit analysis to be of appropriate outcome measures.Hadler et al 50 on the other, suggesting a serious degree of reassessed.Upgrading the equipment commonly used one: the disability score designed by Roland inconsistency in the review process.results in faster throughput, better discrimination, and Morris and shown by them to be a more Whether the term manipulation should be used, and added diagnostic value-for example, that reliable and sensitive index of disability in back as Koes and colleagues used it, "to cover both provided by angiography-with the result that it pain than measures such as pain experienced or manipulation and mobilisation" is at least arguable.tends to be cost neutral on a per patient basis.spinal mobility,' for which Koes and colleagues Their conclusions about manipulation (thus In their analysis Szczepura and colleagues would have awarded points, defined) in back pain seem analogous to generalisacalculated that changes in patients' management Ten points were available If the five suggested tions about antibiotics for sore throat.helped to reduce the costs of examination by £80 outcome measures were measured blind.Hadler T W MEADE and, furthermore, that if half of the diagnostic et al relied on a patient questionnaire administered JOY TOWNSEND procedures performed in addition to magnetic over the telephone by someone unaware of the
DEATH AND RESURRECTION AND NEWSPAPER ENTERPRISE.
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PARESIS AMONG THE JEWS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasound Useful in Diagnosing Oral-Motor Dysfunction
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the British Thoracic Society
Journal: Thorax (1984)

held on 4-6 July at the Hotel Metropole, Brighton Undertreatment of asthma in general practice CR HORN, GM COCHRANE The piersistent failure of modern drugs to reduce the excessive death rate from asthma may be the result of undertreatment of patients.We studied 120 patients in two general practices to determine the ad- equacy of their treatment.Only 50% of the patients had normal spirometric results and in over 20% they were below 50% of predicted values.Worsening spirometric values was associated with a considerable increase in reported morbidity (r = -0-4: p < 0-001).The use of therapy was significantly correlated with increasing sev- erity of asthma, subjects with an FEV, within normal limits using, on average, 1-2 drugs compared with 2-4 drugs per subject among those with an FEV, l'eissthan 50% predicted (p < 0-001).Despite this only 50% of those with an FEV, below 50% predicted were having an inhaled steroid and fewer than 50% took f agonist inhalers on a regular basis.
Soluble immune checkpoints are involved in the immunopathogenesis of ACLF
Authors: Douglas Corrigall, Nicola Harris, Dhruti Devshi, Sarah Fairclough, Gavin Wright, Jonel Trebicka, Carlo Alessandria, Paolo Angeli, Rajiv Jalan, Joan Claria, Richard Moreau, Vicente Arroyo, Roger Williams, Antonio Riva, Shilpa Chokshi
Journal: Journal of Hepatology (2020)
Review of updated gastric cancer disease management data in the Colombian National Administrative Cancer Registry.
Authors: Robert Hsu, Paula Ramirez, Lizbeth Acuña, Gilberto Lopes
Journal: Journal of Clinical Oncology (2019)

30 Background: The Office of High Cost of the Colombian Health Ministry created the National Administrative Cancer Registry (NACR) in 2015 to obtain nationwide cancer data to find areas for improvement in cancer delivery. From initial data, a collaboration of healthcare experts identified 16 disease management indicators in gastric cancer (GC) in Colombia. In this study, we look at 2017 NACR data to investigate significant findings. Methods: We obtained NACR data compiled from the Department of Health Ministry from January 2, 2016- January 1, 2017 consisting of 32 departments and 1,122 municipalities. The 2017 NACR data for GC includes 13 of the 16 updated disease management indicators—time to diagnosis, percentage of patients with gastric cancer in situ, proportion of new cases identified in early stages, proportion of patients with TNM staging, time before treatment, time between neoadjuvant therapy and surgery, time between surgery and adjuvant therapy, proportion of stage 0-III patients receiving surgery with curative intent, proportion with nutrition support, proportion of surgical patients with nutrition support, mortality rate, and incidence. Results: The incidence of GC was 3.6 cases per 100,000 people and mortality was 3.6 cases per 100,000 people. The time to diagnosis was on average 43.7 days. 6.9% of stageable GC cases were in situ. 25.6% of cases were identified in early stages, and 50.7% of cases had TNM staging. The time to initial treatment was 60.3 days. The time between neoadjuvant therapy and surgery was 109.6 days and the time between surgery and adjuvant therapy was 75.5 days. 25.9% of stage 0-III patients received surgery with curative intent. 16.3% of GC patients received nutritional support along with 15.2% of surgical GC patients. Conclusions: Updated NACR data show long wait times for patients needing neoadjuvant or adjuvant therapies suggesting improvement in follow-up management. The low percentage of patients with nutritional support shows the need for supportive services. There should be strategies for earlier diagnosis given the low percentage of patients identified at early stages. Further directions include 2 and 5 year survival data and data on interdisciplinary care.
"ACUTE PNEUMONITIS" VIRUS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal