tbuckley/cabot-search huggingface dataset:
Reoperative Surgery
Authors: Leo M. Zimmerman
Journal: JAMA (1965)

The widening range of medical knowledge necessitates a growing specialization in its literature. The above treatise, dealing only with reoperative surgery, indicates this trend. The editor correctly points out that even well-performed operations sometimes fail to achieve their anticipated results; and that the problems attending the second intervention may be different from, and more serious, than those of the initial operation. The cumulative derangements in physiology resulting from the illness itself, the original operation, and the intervening period of malfunction often reduce the patient to a state highly precarious for withstanding another taxing surgical ordeal. Preoperative rehabilitation, anesthesia, and postoperative care become especially critical under these conditions. Anatomic difficulties may be likewise aggravated by the first intervention, and by complications following in its wake. The editor has succeeded in enlisting the cooperation of a truly distinguished and authoritative body of contributors. The text has been well edited and is liberally
HOSPITAL CORPS EQUIPMENT AND DRILL.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environmental Xenobiotics May Disrupt Normal Endocrine Function by Interfering with the Binding of Physiological Ligands to Steroid Receptors and Binding Proteins
Authors: Benjamin J. Danzo
Journal: Environmental Health Perspectives (1997)

The disruption of the reproductive system of male and female animals in the wild has been attributed to environmental chemicals (xenobiotics). The effects seen mirror alterations one might anticipate if the steroid hormone-dependent processes that regulate these systems were impaired. To determine whether xenobiotics (present at a concentration of 100 microM) exert their action through steroid-mediated pathways, we examined their ability to inhibit the binding of [3H]physiological ligands (present at a concentration of 7 nM) to the androgen and estrogen receptors, rat androgen-binding protein (ABP), and human sex hormone-binding globulin (hSHBG). The gamma- and delta-isomers of hexachlorocyclohexane, congeners of dichlorodiphenyl-trichloroethane (DDT; p,p'-DDT; p,p'-DDE; o,p'-DDT), dieldrin, atrazine, and pentachlorophenol, caused a statistically significant inhibition of specific binding of [3H]5 alpha-DHT to the androgen receptor that ranged from 100% (p,p'-DDE) to 25% (dieldrin). Methoxychlor, o,p'-DDT1, pentachlorophenol, and nonylphenol significantly reduced [3H]17 beta-estradiol binding to the estrogen receptor by 10, 60, 20, and 75%, respectively. The binding of [3H]5 alpha-DHT to ABP was inhibited 70% by the delta-isomer of hexachlorocyclohexane, but the gamma-isomer did not reduce binding significantly. Methoxychlor, p,p'-DDT, atrazine, and nonylphenol reduced [3H]5 alpha-DHT binding to ABP by approximately 40%. Nonylphenol reduced the binding of [3H]5 alpha-DHT to hSHBG by 70%. Hexachlorocyclohexane reduced [3H]5 alpha-DHT binding to hSHBG by 20%, but the stereospecific effects observed with ABP did not occur. o,p'-DDT and pentachlorophenol resulted in a statistically significant 20% inhibition of [3H]5 alpha-DHT binding to hSHBG. Some xenobiotics resulted in dissociation of [3H]ligands from their binding proteins that was statistically identical to that caused by the unlabeled natural ligand, whereas others resulted in slower or more rapid dissociation rates.
THE CHAMBER OF HORRORS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Pflanzenalkaloide.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic silicosis, cirrhosis, and liver tumors in mice and hamsters: Studies of transforming growth factor beta expression
Authors: A Williams
Journal: Hepatology (1996)

Hepatic silicosis, cirrhosis, liver cell adenoma, and carcinomas developed in nude mice (NCr-Nu) given quartz by the subcutaneous and intraperitoneal routes. Syrian golden hamsters (15:16 EHS:cr) given quartz by both routes developed extensive fibrosis and cirrhosis and had higher morbidity and mortality rates after 3 months. Crystalline silica (quartz) induces fibrosis, adenomas, and carcinomas in the lungs of Fisher 344 rats, but certain strains of mice and hamsters are resistant to quartz-induced pulmonary carcinogenesis. Pulmonary fibrosis, however, is minimal in mice and absent in hamsters who received quartz intratracheally. To determine whether species differences are due to organ-specific rather than species-specific factors, susceptibility of the liver to quartz toxicity was investigated in nude mice and hamsters. The present study shows that the differential manifestations of quartz toxicity by these rodent species are dependent on factors that are organ-specific rather than host-specific. At 3 months, hepatocytes in mice were immunostained with intracellular transforming growth factor (TGF) beta 1 (LC 1-30) but not with TGF-beta 1 latency-associated peptide (LAP) protein (266-278); at 12 months, hepatocytes were immunostained with TGF-beta 1 LAP (266-278) but not with TGF-beta 1 (LC1-30). The hepatocytes of hamsters at 3 months showed immunoreactivities to TGF-beta 1 LAP (266-278) and TGF-beta 1 (LC1-30); immunostaining to TGF-beta 1 (LC1-30) was detected in nonparenchymal cells. Extracellular TGF-beta 1 (CC1-30) was detected in the silicotic granulomas and fibrous tissue in livers of both species. Quartz-induced liver carcinoma did not express TGF-beta 1 LAP (266-278) and LC (1-30) proteins, but these were detected in the cells of the adenoma in the same liver. Control animals showed no hepatic lesions nor immunoreactivity to TGF-beta 1. The spatial and temporal patterns of expression of TGF-beta 1, TGF-beta 2, TGF-beta receptor type II messenger RNAs (mRNAs), and TGF-beta 1 proteins in the different hepatic lesions suggests that TGF-beta isoforms may play a role in the pathogenesis of quartz-induced fibrosis, cirrhosis, liver cell adenoma, and carcinoma. (Hepatology 1996 May;23(5):1268-75)
带状疱疹疾病负担的不均衡:基于人群的队列研究
Authors: A. Jain, A.J. van Hoek, J.L. Walker, H.J. Forbes, S.M. Langan, A. Root, L. Smeeth, S.L. Thomass
Journal: British Journal of Dermatology (2018)

本研究由英国伦敦卫生与热带医学院的一支工作团队实施,对2003至2013年期间因受到带状疱疹的侵袭而到全科医生处问诊的一大群年龄在65岁及以上的患者进行了调查。信息来源是一个被称为临床实践研究数据链接的匿名数据库,该数据库记录了来自英国多项全科治疗的信息。这些数据是在英国引进带状疱疹疫苗前获取的。在37,000多名带状疱疹患者中,住在疗养院的人、女性、非移民(白人种族人群)以及独居者的感染率较高。住在贫民区的人群的感染率相对较低。接受治疗导致整体免疫水平下降的患者更易患上带状疱疹,但是糖尿病患者则不会。作者认为,提高某些群体(例如住在疗养院的人)的免疫力可能会对防止患上带状疱疹有所帮助.
Law and Medicine
Authors: Lawrence O. Gostin
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Lead on Neurophysiological and Performance Measures: Animal and Human Data
Authors: Hellmuth Lilienthal, Gerhard Winneke, Torsten Ewert
Journal: Environmental Health Perspectives (1990)

This paper reports lead-induced changes in neuropsychological measures and behavioral performance measures in monkeys and children. Monkeys were pre- and postnatally exposed to lead via the diet. Blood lead levels at the time of testing were 9.3, 40.3, and 55.7 micrograms/dL in controls, and animals exposed to 350 ppm or 600 ppm lead acetate, respectively. Flash-evoked and brainstem auditory-evoked potentials were recorded in adult animals. Results indicate latency increases in both measures as well as amplitude decreases in the flash-evoked response. Delayed reaction time and serial choice reaction were determined as measures of behavioral performance in lead-exposed school-age children from two lead smelter areas. In addition, pattern-reversal-evoked potentials and nerve conduction velocity were investigated. Neither nerve conduction velocity nor latency of the pattern-reversal-evoked potential were consistently influenced by lead. Of the behavioral measures, serial choice reaction performance revealed a consistent lead-related deficit, which became more pronounced with increasing task difficulty.
Vancomycin-streptomycin synergism in enterococcal endocarditis
Authors: G. O. Westenfelder
Journal: JAMA (1973)

On rare occasion a patient with enterococcal (group D streptococcal) endocarditis will exhibit life-threatening penicillin allergy. The selection of vancomycin hydrochloride and streptomycin as alternate therapy to penicillin-streptomycin under such circumstances is supported by a patient here reported who was cured of enterococcal endocarditis after being treated with vancomycin-streptomycin. In addition, studies upon 18 enterococcal isolates confirm previously reported investigations which indicate that vancomycin and streptomycin in combination exert a synergistic action against a substantial percentage of enterococcal isolates in vitro.
Cats and toxoplasmosis risk in HIV-infected adults
Authors: M. R. Wallace
Journal: JAMA (1993)

<h3>Objective.</h3> —To establish the prevalence and incidence of toxoplasmosis in an adult human immunodeficiency virus (HIV) population, and to determine if cat ownership contributes to the risk of toxoplasmosis. <h3>Design.</h3> —Retrospective record and laboratory review, coupled with a patient survey. <h3>Setting.</h3> —A tertiary-care military hospital HIV program. <h3>Patients.</h3> —A total of 723 HIV-infected adults, all former or current US military personnel. <h3>Main Outcome Measures.</h3> —Prevalence and incidence of serologic evidence of toxoplasmosis infection. <h3>Results.</h3> —A total of 723 HIV-infected patients had serial<i>Toxoplasma</i>IgG antibody determinations. Seventy patients (9.7%) were positive on their initial screen; the seronegative patients were tested annually for 1 to 5 years (mean duration of follow-up, 2.1 years). Only 13 patients (2.0%) who were initially seronegative acquired antibodies to<i>Toxoplasma gondii</i>. None of the patients who seroconverted developed clinical disease. A pet history was available on 12 of 13 patients who seroconverted; only one (8.3%) had owned or lived in a household with a cat during the period of seroconversion. The calculated attributable risk of cat ownership/ exposure for toxoplasmosis seroconversion in this population is -2.9 per 100 persons annually. <h3>Conclusion.</h3> —<i>Toxoplasma</i>antibody seroconversion in an adult HIV-infected population is unusual and appears unrelated to cat ownership or exposure. (<i>JAMA</i>. 1993;269:76-77)
Mendelian Inheritance Of Elevated Tryptase Associated With Atopy and Connective Tissue Abnormalities
Authors: Jonathan J. Lyons, Guangping Sun, Kelly D. Stone, Celeste Nelson, Laura Wisch, Michelle O'Brien, Nina Jones, Andrew W. Lindsley, Hirsh D. Komarow, Yun Bai, Linda M. Scott, Daly Cantave, Irina Maric, J. Pablo Abonia, Marc E. Rothenberg, Lawrence B. Schwartz, Todd M. Wilson, Joshua D. Milner
Journal: Journal of Allergy and Clinical Immunology (2014)
Understanding patients' cultural beliefs helps health providers serve them better
Journal: BMJ (1998)

Colloids no better than crystalloids for fluid replacement in hypovolaemic patientsFor decades controversy has existed over the relative benefits of colloid and crystalloid solutions for fluid resuscitation of hypovolaemic patients.In their systematic review of randomised controlled trials Schierhout and Roberts (p 961) found that, compared with crystalloids, use of colloids was associated with an increase in absolute risk of mortality of 4%.There was no evidence for differences of effect among different types of injury necessitating fluid resuscitation.The authors conclude that there is no evidence to support the continued use of the more expensive colloids for acute volume replacement in critically ill patients.
BIRTCHER MODEL 799 ELECTROSURGICAL UNIT ACCEPTABLE
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intestinal Myiasis
Authors: F. I. van Emden
Journal: BMJ (1947)

SIR,-" Peace hath her victories no less renowned than war" could hardly be better illustrated than by the abbreviated Journal of the last fortnight, upon which, Sir, the profession must most warmly congratulate you.May I plead that some of this excellent editorial pr6cis writing is continued ?Without it how many of us would have learnt that "
Renal lesions, gross hematuria, and marrow granulomas in infectious mononucleosis
Authors: E. A. Taub
Journal: JAMA (1966)

HEMORRHAGIC manifestations of infectious mononucleosis are not uncommon. Virtually every organ system has been involved.<sup>1</sup>Gross hematuria is quite rare, and renal biopsies have not been done in the few cases reported. Granuloma formation in the bone marrow in infectious mononucleosis is a phenomenon which was first reported less than 20 years ago.<sup>2</sup>This finding, although reported to be quite common, does not yet seem to be within the realm of common medical knowledge. It will be the purpose of this paper to present and discuss the significance of a case of infectious mononucleosis associated with granulomatous changes in the bone marrow, unique renal lesions, and gross hematuria. <h3>Report of a Case</h3> The patient is a 19-year-old white boy, who had been experiencing confusion, visual hallucinations, chills, fever, sore throat, and grossly bloody urine during the week preceding his hospital admission. The patient was seen by a local
Einführung in die allgemeine Konstitutions- und Vererbungs-pathologie. Ein Lehrbuch für Studierende und Aerzte.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent events of special interest to medical education
Authors: R. L. Egan
Journal: JAMA (1985)

For several years this section of the EDUCATION ISSUE has reviewed "Recent Events of Special Interest to Medical Education." An event of current importance to the education of physicians in the United States is the recent revision of standards. On Feb 19,1985, the Liaison Committee on Medical Education (LCME) adopted a new set of standards for programs conducted by US medical schools. These standards were subsequently approved by the American Medical Association (AMA) Council on Medical Education (March 3, 1985) and by the Association of American Medical Colleges (AAMC) Executive Council (April 4, 1985). The document, "Functions and Structure of a Medical School; Standards for Accreditation of Medical Education Programs Leading to the MD Degree" is reprinted in this section of the EDUCATION ISSUE. Eighty-five years ago this month the first EDUCATION ISSUE contained an article entitled "Changes in Our Medical Schools Necessary to Meet Modern Conditions."1 At that time
Notifiable diseases.
Authors: M. Dryden, R. Gabb
Journal: BMJ (1992)

vivors were interviewed about the advice they had been given during and after their admission concerning smoking, diet, and exercise.When appropriate, patients were asked whether the result of serum cholesterol estimation had been discussed with them.Results were analysed with the xI test with Yates's correction.There were 142 eligible admissions (85 men).Thirty patients died before interview, and 17 refused consent or had dementia.The 95 subjects (58 men) interviewed had a median-age of75 (range 70-86) and were interviewed a median of8-6 (range 2 6-14) months after admisson.-Fifteenhad regularly smoked cigarettes.Twelve had been advised to stop and 11 had either done so or cut down considerably.One of the three with whom
Six Prescriptions
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal