tbuckley/cabot-search huggingface dataset:
Meetings Outside the United States
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Symposium on Basic Problems in Neoplastic Disease
Journal: JNCI Journal of the National Cancer Institute (1961)

Symposium on Basic Problems in Neoplastic Disease JNCI: Journal of the National Cancer Institute, Volume 27, Issue 4, October 1961, Page 935, https://doi.org/10.1093/jnci/27.4.935 Published: 01 October 1961
Small Cell Lung Cancer
Authors: Gregory P Kalemkerian, Wallace Akerley, Paul Bogner, Hossein Borghaei, Laura Chow, Robert J Downey, Leena Gandhi, Apar Kishor P Ganti, Ramaswamy Govindan, John C Grecula, James Hayman, Rebecca Suk Heist, Leora Horn, Thierry M Jahan, Marianna Koczywas, Cesar A Moran, Harvey B Niell, Janis O'Malley, Jyoti D Patel, Neal Ready, Charles M Rudin, Charles C Williams
Journal: Journal of the National Comprehensive Cancer Network (2011)
Forensic Pathology
Authors: James L. Luke
Journal: New England Journal of Medicine (1976)

During the course of a decade as a forensic pathologist, I have watched with interest the individual and collective reaction of others to what I do, or, more properly, to what they think I do. Their confusion is valid; forensic pathology is the invisible profession. Having dealt with more than my share of others' misconceptions of my responsibilities, physicians and attorneys included, I start by setting the semantic record straight. The forensic sciences (of which forensic pathology is a component) are where science and the law meet in daily adjustment.The responsibility of a forensic pathologist is not simply to . . .
Cardiac involvement in rheumatoid arthritis. An echocardiographic study.
Authors: P A Bacon, D G Gibson
Journal: Annals of the Rheumatic Diseases (1974)

Exposure to swine confinement buildings has a negative impact on respiratory health. A short exposure to this environment results in an acute airway inflammatory response. The present study was performed to confirm and further define the acute effects of working in a swine building, and to determine whether these effects are reproducible. Seven previously nonexposed normal subjects underwent evaluations that included hourly measurement of forced expiratory volume in one second (FEV1), methacholine challenge (the provocative concentration producing a 20% fall in FEV1 (PC20)), bronchoalveolar lavage (BAL), nasal lavage (NL), and blood analyses, before (control) and after each of two 5 h exposures to a swine building environment. The exposures were conducted 8 days apart. The levels of total dust, endotoxins, and ammonia (NH3) in the confinement building were measured on each day of exposure. Both exposures resulted in a significant reduction in FEV1 (mean+/-SEM change in FEV1: control = 7+/-2%; exposure 1 = 15+/-3%; exposure 2 = 23+/-3%), decrease in PC20 (median value (25th-75th percentile): 223 (23-256), 20 (15-198) and 20 (11-71), respectively; p=0.05) and increase in BAL cells (129+/-20, 451+/-43 and 511+/-103x10(3) cells x mL(-1), respectively) and NL cells (6+/-4, 126+/-58 and 103+/-26x10(3) cells x mL(-1), respectively), mostly neutrophils. Levels of interleukin-8 (IL-8), but not interleukin-1 (IL-1) or tumour necrosis factors (TNF-alpha), increased both in BAL and nasal fluids with exposure. In normal naive subjects, repeated exposure to the environment of a swine building induced a marked and reproducible reduction in forced expiratory volume in one second, increase in airway responsiveness, and increased neutrophilic inflammatory response. These results could not be accounted for by any of the environmental factors measured.
Contents
Authors: Debarun Dutta, Harsha Rao, Uday Addepalli, Pravin Vaddavalli, Saideep Bose, Marcus Ang, Jodhbir Mehta, Donald Tan, Eric Finkelstein, Vincenzo Scorcia, Massimo Busin, Andrea Lucisano, Jacqueline Beltz, Arturo Carta, Giovanni Scorcia, Youngsub Eom, Su-Yeon Kang, Jong-Suk Song, Hyo Kim, Marios Constantinou, Vishal Jhanji, Xie Jing, Ecosse Lamoureux, Umberto Boffa, Hugh Taylor, David Abramson, Jasmine Francis, Ira Dunkel, Brian Marr, Scott Brodie, Y Gobin
Journal: Ophthalmology (2013)
Novel experimental animal models for acute decompensation and acute-on-chronic liver failure
Authors: Frank Uschner, Sabine Klein, Cristina Ortiz, Robert Schierwagen, Olaf Tyc, Christiana Graf, Alexander Queck, Marcus Maximilian Muecke, Victoria Mücke, Katharina Maria Schwarzkopf, Hans-Peter Erasmus, Martin Schulz, Stefan Zeuzem, Vicente Arroyo, Joan Claria, Jonel Trebicka
Journal: Journal of Hepatology (2020)
Paraben Allergy
Authors: James E. Nagel
Journal: JAMA (1977)

A hydrocortisone preparation containing methylparaben and propylparaben provoked bronchospasm and pruritis when given intravenously to an asthmatic patient, whereas another hydrocortisone preparation without paraben preservative did not. Direct and passive transfer (Prausnitz-Küstner) skin tests for immediate hypersensitivity to parabens were positive. Parabens, frequently employed as bacteriostatic agents, are capable of producing immunologically mediated, immediate systemic hypersensitivity reactions. (<i>JAMA</i>237:1594-1595, 1977)
<i>Recherches Cliniques et Thrapeutiques sur l'Epilesic, l'Hystélé et l'diotic</i>. Compte Rendue du Service des Enfants, Idiots. Epileptiques et arribrés du Bicêtre pendant l'année 1890. Par Bourneville, Medecin de Bicêtre, Avec Ia collaboration de MM. Camescasse, lsch-Wall, Morax, Raoult, Séglas et P. Sollier. Vol. XI. Avec 16 figures dans le Texte et 10 planches. Paris, 1891 (Clinical and Therapeutic Investigations on Epilepsy, Hysteria and Idiocy.)
Authors: H. M. B.
Journal: American Journal of Psychiatry (1892)
THER-28. A CK1α ACTIVATOR PENETRATES THE BRAIN, AND SHOWS EFFICACY AGAINST DRUG-RESISTANT METASTATIC MEDULLOBLASTOMA
Authors: Jezabel Rodriguez, Bin Li, Jun Long, Chen Shen, Fan Yang, Darren Orthon, Sara Collins, Noriyuki Kasahara, Nagi Ayad, Heather McCrea, Martine Roussel, William Weiss, Anthony Capobianco, David Robbins
Journal: Neuro-Oncology (2019)

Although most children with medulloblastoma (MB) are cured of their disease, SONIC HEDGEHOG (SHH) subgroup MB driven by TRP53 mutations is essentially lethal. Casein Kinase 1α (CK1α) phosphorylates and destabilizes GLI transcription factors, thereby inhibiting the key effectors of SHH signaling. We therefore tested a second-generation CK1α activator against, TRP53 mutant, MYCN amplified MB. Our novel CK1α activator inhibited SHH activity in vitro, acting downstream of the vismodegib target SMOOTHENED (SMO), and reduced the viability of sphere cultures derived from SHH MB. SSTC3 accumulated in the brain, inhibited growth of SHH MB tumors, and blocked metastases in a genetically-engineered vismodegib-resistant mouse model of SHH MB. Importantly, SSTC3 attenuated growth and metastasis of orthotopic patient-derived TRP53 mutant, MYCN amplified, SHH subgroup MB xenografts, increasing overall survival. Thus, a CK1α agonist penetrates into the brain, and shows efficacy against metastatic TRP53 mutant MB, which are resistant to existing therapies including the SMO inhibitors currently being evaluated clinically.
Software
Authors: Mark Helfand
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Buoyancy
Authors: Ellen Zhang
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic significance of symptoms of advanced cancer patients
Authors: S. Teunissen, A. De Graeff, E. Voest, J. De Haes
Journal: Journal of Clinical Oncology (2004)

8150 Background: Advanced cancer Palliative care patients have a variety of distressing symptoms. Their prognostic significance with regard to survival has not been systematically studied. Methods: Symptoms (type and severity) were assessed during an in-depth interview by a clinical nurse specialist with 166 cancer patients (46% male, 54% female) referred to a university hospital palliative care teamnurse specialist. WHO performance status: 2% 1, 27% 2, 50% 3, 21% 4. Diagnosis: 14% breast, 11% gynaecological, 19% gastrointestinal, 11% head and neck, 11% lung, 8% prostate and 26% other types of cancer. For 90 patients scores were available from the Edmonton Symptom Assessment Schedule (ESAS). Medical data and survival were recorded. The prognostic significance of the most frequent symptoms was analysed using Kaplan-Meier and multivariate linear and logistic regression analyses. Results: We recorded 29 different physical and psychological symptoms occurring in ≥10% of patients. 96% of the patients has have died. Survival at two months was 51%. In univariate analysis, headache, abdominal pain, pain in an extremity, anorexia, nausea, vomiting, dysphagia, dyspnea, drowsiness, confusion and depression were predictive of survival. The ESAS-scores for anorexia, nausea, dysphagia, dyspnea and drowsiness were significantly correlated with survival. After correcting for diagnosis, dyspnea, dysphagia, vomiting, confusion and nausea vomiting, confusion and nausea (occurring in 31%, 11%, 25%, 17% and 39%, 25%, 17% and 39% of patients, respectively) were independent predictive factors of survival. Patients with confusion, dyspnea, dysphagia or vomiting had an increased chance of dying within two months of 9.4, 7.3, 4.3, and 4.,3, respectively, compared to patients without these symptoms. Conclusion: Patients with confusion, dyspnea, dysphagia, vomiting or nausea have a significantly worse prognosis, regardless of diagnosis. A comprehensive assessment of symptoms is useful to determine prognosis in advanced cancer patients. No significant financial relationships to disclose.
Liver Scanning in the Diagnosis of Hematobilia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chest wall lesions mimicking intrapulmonary pathological conditions
Authors: M. S. Shin
Journal: JAMA (1978)

THE NIPPLE shadow has been described in the literature as a chest wall normality that may, at times, be mistaken for a pulmonary nodule.<sup>1</sup>We present here six cases of other chest wall lesions that may cause confusion in the interpretation of the chest roentgenogram unless careful systematic evaluation of both posteroanterior (PA) and lateral chest roentgenograms and adequate clinical correlation are obtained. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 50-year-old woman was admitted for a routine chest examination. Two ill-defined oval opacities were identified over the left upper lung in the PA chest roentgenogram (Fig 1, left); however, they were not seen in the lateral chest roentgenogram. The patient had neurofibromatosis. The roentgenologist examined the patient and found numerous cutaneous nodules. Therefore, a repeated chest roentgenogram was obtained with barium taped to two of these nodules, proving their chest wall location (Fig 1, right). <h3>Case 2.—</h3> A 30-year-old man
Chronic mucocutaneous candidiasis. Influence of thyroid status
Authors: L. F. Montes
Journal: JAMA (1972)

It has been said that<i>Candida albicans</i>can be a better clinician than most physicians and may detect systemic abnormalities before they are recognizable at the laboratory level. Chronic mucocutaneous candidiasis developed in a 7-year-old boy long before a diagnosis of marked hypothyroidism (thyroid stimulating hormone, 825μU/ml; T<sub>4</sub>test [tetraiodothyronine], 0.3μg/100 ml) could be established. Normalization of the thyroid status by replacement therapy resulted in dramatic improvement of the infection which had previously been resistant to prolonged anticandidal treatment.
6Ca2+9i responses during proliferation and differentiation of hepatocytes immortalized by transduction with a thermolabile mutant SV40 large T antigen . Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan; and *Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York
Journal: Hepatology (1995)

To determine if luteinizing human granulosa cells contain messenger ribonucleic acid (mRNAs) encoding insulin-like growth factor-binding protein (IGFBPs) and if cultured granulosa secrete IGFBPs into conditioned medium (CM).Northern analysis, using IGFBP-specific complementary deoxyribonucleic acid probes, was used to detect granulosa-derived IGFBP mRNAs. Western ligand blot analysis of CM was used to detect IGFBPs secreted by granulosa cultures with and without human chorionic gonadotropin (hCG).Granulosa cells were obtained from the In Vitro Fertilization (IVF) Program at Stanford University, a private teaching institution.Patients undergoing IVF for tubal disease.None.Transcripts of IGFBP mRNA and IGFBPs secreted into CM were detected by autoradiography of Northern and Western ligand blots, respectively.Transcripts of IGFBP-3, IGFBP-2, and IGFBP-1 mRNA were detected in human luteinizing granulosa. Cultured granulosa secreted IGFBPs with molecular weights corresponding to IGFBP-3, IGFBP-2, and IGFBP-1, and the latter two IGFBPs increased with 10 ng/mL hCG. A 24 kd IGFBP was noted, which may be newly characterized IGFBP-4.These data show that luteinizing human granulosa cells express mRNAs encoding three IGFBPs, secrete IGFBPs into culture medium, and that production of at least two of the IGFBPs is hCG-dependent, further supporting a role for the IGF system in human folliculogenesis.
STAB WOUND THROUGH BOTH VENTRICLES OF THE HEART, WITH RECOVERY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organizing organized medicine through a planning and development framework (PADFRAME)
Authors: G. Stuehler
Journal: JAMA (1977)

PHYSICIANS must substantially expand their societal role beyond self-regulation. Some physicians and other persons have long recognized this need and have urged organized medicine to action. In his 1970 Shattuck Lecture, Dr C. Rollins Hanlon<sup>1</sup>suggested that the difficult priority decisions that must be made concerning the development of health resources should be made by competent professionals in medicine. He argued that expanded roles for organized medicine and inspired leadership in it not only would enhance public respect for organized medicine, but also would be the essential responses to the new political coalitions forming in the health field. In 1971, Dr George Himler<sup>2</sup>underscored the need for effective participation of organized medicine in the formative phase of a system of health care and identified the need for organized medicine to develop flexibility and toughness in promoting the enlightened self-interest of medicine. However, frustrated with the ability of organized
A CASE OF TORSION OF THE OMENTUM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dr. Chan
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treating acute acetaminophen poisoning with acetylcysteine
Authors: R. G. Peterson
Journal: JAMA (1977)

A patient ingested 15.6 gm acetaminophen and sought medical attention after seven hours. At that time, her plasma acetaminophen level was 217μg/ml. Treatment with acetylcysteine was begun eight hours after the ingestion. The clinical course of this patient was characterized by a mild illness with a minor elevation of liver enzyme values. A number of factors predicted severe hepatotoxicity for this patient had she not received treatment. (<i>JAMA</i>237:2406-2407, 1977)