tbuckley/cabot-search huggingface dataset:
Swine flu vaccine and multiple sclerosis
Authors: L. T. Kurland
Journal: JAMA (1984)

Using age-specific rates for multiple sclerosis (MS) based on a national survey, the number of "naturally occurring" new cases of MS among the 45 million swine flu vaccine recipients in the United States is estimated as 1,624 during the year after vaccination, or 31 cases per week. Information from available reports and publications indicates no excess over the expected frequencies. Analyses of admissions for MS before, during, and after the immunization program showed no increase to the US Army hospitals or to the Mayo Clinic. Three independent controlled clinical investigations performed on patients with MS showed no increase in the frequency of exacerbations among those receiving swine flu vaccine as compared with those receiving placebo. Epidemiologic features of MS do not implicate killed virus vaccine as an etiologic factor in onset or exacerbations of the disease. There is no indication from these analyses of any association or cause-and-effect relationship between swine flu vaccine and MS. (<i>JAMA</i>1984;251:2672-2675)
GENEVA
Journal: JAMA (1927)

<h3>Postoperative Pulmonary Complications</h3> Drs. Perrier and Charles Saloz recently discussed postoperative pulmonary complications at a meeting of the Geneva Medical Society. The frequency of pulmonary complications is about 7 per cent after abdominal operations, and there is a mortality of 30 per cent. Pulmonary embolus is rare in operations on the neck and limbs, but occurs frequently in operations undertaken between the diaphragm and the perineum. The lungs react by an area of congestion, infarct, gangrene, pneumonia or bronchopneumonia, processes that may be slight or very serious. Many factors have been invoked in the etiology of these complication: first of all, ether narcosis and aspiration pneumonia; yet the same percentage is to be found following local anesthesia. Lesions of the abdominal vagus are supposed to cause neuritis, which in turn reacts on the pulmonary branches of this nerve. Both causes are certain, but they are simply adjuvant; the primal factor
Huntington's Chorea in Northamptonshire
Authors: M. J. Pleydell
Journal: BMJ (1955)

DITJISHRNAL 889 from fomites has been noted.Clinical and laboratory findings in both acute and chronic infection are described and references made to latent infection and the carrier state.The possible existence of a transient trichomonaemia is considered.Treatment of the acute stage is by urethral instillation of bactericidal drugs; chronic infection requires both general and local treatment.The medico-social aspects of trichomonal infec- tion are discussed.
Down-regulation of interferon-gamma signaling by gene transfer of Stat1 mutant in mesangial cells
Authors: Minoru Sakatsume, Ichiei Narita, Hajime Yamazaki, Akihiko Saito, Yoichi Nakagawa, Hideyuki Kuriyama, Ryozo Kuwano, Fumitake Gejyo, Masaaki Arakawa
Journal: Kidney International (2000)
Reply
Authors: J. R Stewart
Journal: Thorax (1984)

A series of xanthine derivatives and papaverine have been studied to determine their abilities to alter tissue levels of cyclic AMP and cyclic GMP, inhibit phosphodiesterase activities, and cause relaxation of pig coronary arteries. The agents selected for this study exhibited a wide range of potencies to inhibit phosphodiesterase activities in the coronary artery supernatant fraction. In addition, some of these agents were up to 10 times more potent as inhibitors of cyclic GMP hydrolysis than of cyclic AMP hydrolysis, while others were 2-4 times more potent as inhibitors of cyclic AMP than of cyclic GMP hydrolysis. The rank order of potencies of these agents to cause relaxation of coronary artery strips was similar to the rank order of potencies to inhibit cyclic nucleotide phosphodiesterase activities. There were, however, some notable exceptions to the correlation between inhibition of cyclic nucleotide phosphodiesterase activities and relaxation. 1-Isoamyl-3-isobutylxanthine was a more potent relaxing agent than might be expected from its relatively low potency to inhibit cyclic nucleotide hydrolysis in tissue extracts. On the other hand, 1-methyl-3-isobutyl-7-(3-chlorobenzyl)-xanthine was one of the more potent inhibitors of cyclic nucleotide hydrolysis but was not as potent in causing relaxation as might have been expected. Exposure of the coronary artery strips to inhibitors caused increases in tissue levels of cyclic AMP and cyclic GMP and there was a statistically significant multiple linear regression of cyclic AMP and cyclic GMP levels on percent relaxation after 5 min of exposure to the agents. Cyclic AMP and cyclic GMP levels made approximately equal contributions to the regression of changes in percent relaxation, as determined by analysis of variance methods. While 1-isoamyl-3-isobutylxanthine did not fit the correlation between phosphodiesterase inhibition and potency to relax the arterial strips as well as the other agents, this agent also was found to cause unexpectedly large increases in cyclic AMP levels. Some agents caused relaxation accompanied by significant elevation of cyclic GMP levels and no significant change in cyclic AMP levels while other agents caused relaxation accompanied by significant increases in cyclic AMP but not cyclic GMP. These data offer some support for a hypothesis that both cyclic AMP and cyclic GMP are involved in the relaxation processes of pig coronary arteries.
Inflammation and fibrosis
Authors: Julien Vergniol, Genevieve Hou, Juliette Foucher, Florence Chenus, Faberes Carole, Faiza Chermak, Aude Lafourniere, Noui Souakri, Victor De Ledinghen, Arevik Mosoian, Yedidya Hong, Adeeb Saiman, Sasan Rahman, Sander Roayaie, Francesc Florman, Mario Cunyat, Meena Stevenson, Bryan Bansal, Aaron Pace, Akie Mochizuki, Keara Towery, James Luyendyk
Journal: Hepatology (2013)

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor activated in cells by hypoxia, as well as other mediators.We
Evaluation of dressing regimens for prevention of infection with peripheral intravenous catheters. Gauze, a transparent polyurethane dressing, and an iodophor-transparent dressing
Authors: D. G. Maki
Journal: JAMA (1987)

Four dressing regimens for peripheral venous catheters were studied in a prospective randomized clinical trial with 2088 Teflon catheters: (1) sterile gauze, replaced every other day, and three dressings left on for the lifetime of the catheter; (2) gauze; (3) a transparent polyurethane dressing; and (4) an iodophor-transparent dressing. The four dressings provided comparable coverage, except moisture accumulated more frequently under the transparent dressings 26% to 28% vs 20% to 21% Cutaneous colonization under the dressing was low level and comparable with all four dressings (range, 100.58 to 100.70 colony-forming units). The rate of local catheter-related infection ≥15 colony-forming units) was also low and did not differ significantly (range, 4.6% to 5.9%); no catheter caused bacteremia. Stepwise logistic multivariate analysis showed cutaneous colonization of the insertion site (relative risk [RR] of infection, 3.86), contamination of the catheter hub (RR, 3.78), moisture under the dressing (RR, 2.48), and prolonged catheterization (RR, 1.75) to be significant risk factors for catheter-related infection. These data indicate that it is not cost-effective to redress peripheral venous catheters at periodic intervals; for most patients, either sterile gauze or a transparent dressing can be used and left on until the catheter is removed. (<i>JAMA</i>1987;258:2396-2403)
PHIMOSIS FORCEPS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A cytokine and angiogenic factor (CAF) analysis in plasma in testicular germ cell tumor patients (TGCTs).
Authors: Michal Chovanec, Michal Mego, Dana Cholujova, Paulina Gronesova, Vera Miskovska, Zuzana Sycova-Mila, Vanda Usakova, Daniela Svetlovska, Peter Bujdak, Stanislav Spanik, Dalibor Ondrus, Jozef Mardiak
Journal: Journal of Clinical Oncology (2015)

e15552 Background: TGCTs is highly curable disease even in metastatic setting, however, a small proportion of patients develop disease relapse. CAFs seem to be a promising biomarkers in several types of cancer and are involved in tumor dissemination and progression. We aimed to link the CAF profile to patients/tumor characteristics in TGCTs. Methods: In this translational study, plasma from 79 male patients (age 19 – 65) with TGCTs was collected before starting first line platinum based chemotherapy. The cohort included stages I-III TGCTs. The concentrations of 51 plasma CAFs were measured using multiplex bead arrays (Human Group I and II cytokine panels and TGF beta by Bio-Plex 200 system (Bio-Rad Laboratories, Hercules, CA). Results: We observed significantly lower levels of IL-12, IL12p40, MIG, IL-7, IL-8, Eotaxin, IP10, MCP 1 MCAF, MIP 1β in seminoma patients compared to non seminoma. Elevated levels of IL2Rα, IL18, Gro α, GHF, MIG, IL6, IL8, IL10 and RANTES correlated with retroperitoneal lymphadenopathy while patients with mediastinal lymphadenopathy had elevated IL18, HGF, MCP3, M CSF, β NGF, IL15. Pulmonary metastases were associated with elevation of IFN α2, IL2Rα, IL16, IL18, Gro α, HGF, MCP3, M CSF, MIG, β NGF, SCGF β, IL6, IL8, IL9, IL10, IL12, VEGF, while liver metastases were associated with elevation of IFN α2, IL2Rα, IL16, IL18, CTACK, Gro α, HGF, MCP3, β NGF, SCGF β, IL6, IL8. Patients with brain metastases had highly elevated SCGF β. Non-pulmonary visceral metastases (NPVM) were associated with elevated IL2 Rα, IL18, Gro α, HGF, MCP3, M CSF, MIG, β NGF, SCGF β, IL2, IL6, IL8, IL9, IL12, FGF basic, MCP 1 MCAF, VEGF compared to patients without NPVM. Conclusions: Using CAF profiling, we revealed differences in subgroups of TGCTs patients. We suggest that this platform may provide valuable insights into TGCTs biology, and could be useful in identification of new therapeutic targets.
Prostate-specific membrane antigen antibody drug conjugate (PSMA ADC): A phase I trial in metastatic castration-resistant prostate cancer (mCRPC) previously treated with a taxane.
Authors: Daniel Peter Petrylak, Philip W. Kantoff, Anthony E. Mega, Nicholas J. Vogelzang, Joe Stephenson, Mark T. Fleming, Nancy Stambler, Michaela Petrini, Kathleen Huang, Robert Joseph Israel
Journal: Journal of Clinical Oncology (2013)

119 Background: The abundant expression of prostate specific membrane antigen (PSMA) on prostate cancer cells provides a rationale for antibody therapy. PSMA ADC, a fully human antibody to PSMA linked to the microtubule disrupting agent monomethyl auristatin E (MMAE), binds PSMA and is internalized within the prostate cancer cell where cleavage by lysosomal enzymes release free MMAE, causing cell cycle arrest and apoptosis. We have completed a phase 1 dose escalation study of PSMA ADC in subjects with taxane-refractory mCRPC. Methods: Eligibility requirements include progressive mCRPC following taxane-containing chemotherapy and ECOG status of 0 or 1. PSMA ADC was administered by IV infusion Q3W for up to 4 cycles. Safety, pharmacokinetics (PK), PSA, circulating tumor cells (CTC), clinical disease progression and immunogenicity to PSMA ADC were assessed. Serum PSMA ADC and total antibody were measured by ELISA, and free MMAE was measured by LC/MS/MS.The dosing cohorts ranged from 0.4 mg/kg to 2.8 mg/kg. Results: 52 subjects with mCRPC were dosed in nine dose levels. All subjects received prior docetaxel, 5 also received cabazitaxel and 3 subjects also received paclitaxel. PSMA ADC was generally well tolerated with the most commonly seen adverse events being anorexia and fatigue. Peripheral neuropathy was reported by 7 subjects after repeated doses. Two were grade 3. Dose limiting toxicities (DLT) seen at 2.8 mg/kg were neutropenia (one death) and reversible liver function tests (LFTs) elevations. Antitumor activity was manifested as reductions either in PSA or CTCs at ≥ 1.8 mg/kg PSMA ADC in approximately 50% of patients. Exposure to PSMA ADC increased with dose and was ~1,000-fold greater than MMAE exposure and no accumulation was observed. Conclusions: PSMA ADC in this study was generally well tolerated in doses up to 2.8 mg/kg every three weeks in subjects with mCRPC, previously treated with taxane. Antitumor activity was seen at higher dose levels. DLTs were neutropenia and reversible LFT abnormalities. The maximum tolerated dose of PSMA ADC was determined to be 2.5 mg/kg. A phase 2 trial in taxane refractory mCRPC has been initiated. Clinical trial information: NCT01414283.
Hereditary Angioedema
Authors: Marco Cicardi, Angelo Agostoni
Journal: New England Journal of Medicine (1996)

“So soon as ever she came into the room I recognized the affection, for there lay, across the face from temple to temple, an oblong tumor almost closing both eyes.” Thus, J.L. Milton in 1876 described one of his patients with angioedema, six years before Quincke introduced the term angioneurotic edema to describe this disease.1 As Dr. Milton pointed out, the clinical syndrome can be identified quickly, but its cause is not so easy to discern. Because of the severity of the symptoms and the need for a specific therapeutic approach, angioedema due to deficiency of C1 inhibitor must be . . .
Role of Chloride in Correction of Alkalosis Associated with Potassium Depletion
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The neurologist's experience with pheochromocytoma. A review of 100 cases
Authors: J. E. Thomas
Journal: JAMA (1966)

This communication is based on a review of the clinical histories of 100 patients with proved pheochromocytoma seen at the Mayo Clinic between 1945 and 1965. The tumor was identified at operation in 97 patients and at autopsy in three. In 85% of cases only one adrenal gland was involved. Symptoms occurred almost always paroxysmally, the commonest symptom combination being headache, perspiration, palpitation, and pallor. The attacks were sudden in onset, generally less than one hour in duration, and of variable frequency. Basal metabolic rate and sugar concentration in the blood were increased in more than half of the patients. The neurological conditions most likely to be confused with pheochromocytoma include vasodilating headache, intracranial tumor, diencephalic-autonomic epilepsy, hypertensive encephalopathy, focal arterial brain disease, and anxiety state.
Study shows little effect of steroids in spinal injury
Authors: P. Gunby
Journal: JAMA (1982)

Despite widespread use of steroids to treat spinal cord injuries, high doses of the agents may have negligible effects, at least in the first six weeks. This preliminary report comes from a randomized, collaborative study, supported by the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS), Bethesda, Md, concerning the possible benefits of two different dosage levels of corticosteroids in treating such injuries. However, principal investigator Michael B. Bracken, PhD, points out that the patients involved will be evaluated further at six months and one year after their injuries. Bracken, a senior research associate and lecturer in epidemiology at Yale University School of Medicine, New Haven, Conn, explained the investigation this way at the annual Honolulu meeting of the American Association of Neurological Surgeons: The study involves 330 patients, in all of whom 11 days of intravenous steroid therapy was started in the emergency department. Half received a
THE EMBRYOLOGICAL BASIS OF PATHOLOGY.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1960)

doctors" in the true sense of the word ?Also should they not be under the same regulations as G.P.s and provide a 24-hours service every day of the year ?Their reward at £4 4s. per visit plus mileage is more than what we get for looking after the patient, which they are asked to visit, for four years.Let us have more " Equality, Fraternity, and
Misspelled Author Name
Journal: JAMA Oncology (2015)

Roberto Salgado, MD, PhD; Carsten Denkert, MD, PhD; Christine Campbell, MSc; Peter Savas, MD; Paolo Nuciforo, MD; Claudia Aura, MD; Evandro de Azambuja, MD, PhD; Holger Eidtmann, MD; Catherine E. Ellis, PhD; José Baselga, MD; Martine J. Piccart-Gebhart, MD, PhD; Stefan Michiels, PhD; Ian Bradbury, PhD; Christos Sotiriou, MD, PhD; Sherene Loi, MD, PhD
Ultrasound in the investigation of gallbladder disease
Authors: N. B. Kappelman
Journal: JAMA (1978)

CONVENTIONAL oral cholecystography with iopanoic acid has reached a high degree of diagnostic accuracy and is currently the standard mode of evaluation of gallbladder disease.<sup>1</sup>However, it is of limited applicability in several situations: The acutely ill patient. The study, when using iopanoic acid may take 14 to 48 hours to complete. The patient who cannot ingest pills. Patients who, because of symptoms or therapy, cannot ingest or retain iopanoic acid or who are undergoing gastric suction must be examined by alternate means. The patient with jaundice and liver function abnormalities. Although nonvisualization of the gallbladder in most cases is highly specific for gallbladder disease,<sup>1</sup>the presence of jaundice or abnormal results from liver function studies is a spurious or nonbiliary cause for nonvisualization and does not necessarily indicate a pathological gallbladder condition. The patient with a nonbiliary cause for nonvisualization. Nonbiliary causes that may
Incomplete Author Name and Credentials in Byline
Journal: JAMA Neurology (2020)

Jin Jing, PhD; Aline Herlopian, MD; Ioannis Karakis, MD; Marcus Ng, MD; Jonathan J. Halford, MD; Alice Lam, MD, PhD; Douglas Maus, MD, PhD; Fonda Chan, MD; Marjan Dolatshahi, MD, MSc; Carlos F. Muniz, MD, MSc; Catherine Chu, MD; Valeria Sacca, MS; Jay Pathmanathan, MD; WenDong Ge, PhD; Haoqi Sun, PhD; Justin Dauwels, PhD; Andrew J. Cole, MD; Daniel B. Hoch, MD; Sydney S. Cash, MD, PhD; M. Brandon Westover, MD, PhD
一项关于儿童皮肤粘蛋白沉积症的回顾
Authors: F. Rongioletti
Journal: British Journal of Dermatology (2020)

粘蛋白是一种胶状物质, 主要由透明质酸组成, 它是皮肤的正常组分, 通常由纤维细胞产生。然而,在称为粘蛋白沉积症的疾病中, 粘蛋白在皮肤中大量累积, 导致肿胀病灶(皮肤受累斑块), 因为里面充水。 皮肤粘蛋白沉积症表示一组成人疾病, 其在儿童中不常见。它们包括系统性(全身)疾病(如硬化性粘液水肿、胫前粘蛋白沉积症或硬化病), 或皮肤限制性疾病(如网状红斑性粘蛋白沉积症、局部粘液水肿性苔藓或皮肤局灶性粘蛋白沉积症)。 人们对儿童中发生的皮肤粘蛋白沉积症的了解不如成人粘蛋白沉积症充分, 因为这类疾病在儿童中很罕见。由于缺乏足够的科学知识或循证建议, 儿童皮肤粘蛋白沉积症的诊断和管理也是一项艰难的任务。 本综述旨在帮助皮肤科医生和儿科医生识别儿童皮肤粘蛋白沉积症患者, 并使他们能够开始适当的治疗。建议建立儿童皮肤粘蛋白沉积症的第一个分类, 以更好地阐明问题。 This summary relates to the study: 原发性儿科皮肤粘蛋白沉积症
Errant genes.
Authors: R Duguid
Journal: BMJ (1970)

Classification).There were 27 spontaneous deliveries, 8 forceps deliveries, and 9 caes- arean sections.In brief, there was a sharp fall in C.V.P. on delivery of the child in every case.During the third stage of labour the C.V.P. ranged from -2 to + 9 cm.H20 (zero level was the sternal angle).Each pa- tient received ergometrine 0-25 mg. or 0-5 mg.intravenously, sometimes before and sometimes after placental separation.Placental separation and the injection of ergometrine produced small and transient rises in C.V.P. (never more than 3 cm.H20 and never lasting for more than 4 minutes).Blood loss was measured at these deliveries and was of the anticipated magnitude.1 2 It is believed that the direct effects of ergo- metrine on the veins were to a variable extent cancelled out by the effects of haemorrhage.
Correction
Journal: BMJ (1963)

EXOMPHALOS MEDBAL JORRNLventral hernia covered by skin, necessitating repair in later life.Both these methods have proved successful and it appears that the conservative treatment of exomphalos major is associated with a lower mortality rate than any operative method.Both methods have the disadvantage that the amniotic sac is not opened, and there is therefore a chance that an underlying intestinal malformation will be missed.In exomphalos severe associated malformations are frequently encountered" and are partly responsible for the high mortality.It is now well established that exomphalos must be treated as an emergency and that delay in treatment after birth may result in drying out and rupturing of the amniotic sac.Post-natal rupture of the exomphalos used to be thought to be a fatal complication, but nowadays this fear is probably exaggerated.On the other hand intrauterine rupture of an exomphalos is still a very dangerous condition, and only a few cases surviving operation for this condition have been reported.7