tbuckley/cabot-search huggingface dataset:
BOOK REVIEWS
Authors: S. R. ROWLEY
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Bone Marrow Transplantation: Current Controversies Robert Peter Gale, Richard E. Champlin, eds. New York: Alan R. Liss, Inc., 1989, 725 pp. $135. SCOTT R. ROWLEY SCOTT R. ROWLEY Hemapheresis Treatment Center The Johns Hopkins Oncology Center600 N. Wolfe St. Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 10, 22 May 1989, Page 810, https://doi.org/10.1093/jnci/81.10.810 Published: 22 May 1989
A COMPREHENSIVE DEFINITION OF THE PRACTICE OF MEDICINE.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preface
Authors: Helmut Bartsch, Ian O'Neill, Fred Kadlubar
Journal: Environmental Health Perspectives (1992)

This first volume focuses on biomarkers of suscep- tibility and includes papers on a) the relationship of molec- ular, chromosomal, and cellular susceptibility markers and the multistage carcinogenesis process in humans; and b) the role of genetic polymorphism of xenobiotic-metabol- izing enzymes in cancer susceptibility.The second volume describes a) recent progress in biomonitoring techniques and molecular dosimetry approaches and their application to various populations exposed to carcinogens; and b) issues and implications for using biomarkers in cancer epidemiology and risk assessment.Interest is increasing in organizing multidisciplinary meetings that bring together experimental oncologists, cancer epidemiologists, geneticists, and clinicians to explore the potential of integrated laboratory and field studies.Although one ofthe first meetings of this kind was in 1972,1 progress was slow in the following decade, as
IV. Der Ort
Journal: Psychotherapy and Psychosomatics (1957)

D er O rt D iese U n te rsu c h u n g ü b e r die B esserung in der P sy ch o th erap ie ist zu einer lan g en R eise gew orden.W ir gingen v o n d er D ü rre im am erik an isch en M ittelw esten aus u n d zogen d a n n d u rch die S prech zim m er v o n P s y c h o th e ra p e u te n in N o rd am erik a u n d E u ro p a , wobei w ir u n s von ih n en b e ric h te n ließen, wie sie ü b e r die B esserung bei ih ren P a tie n te n d a c h te n .D a n n b eg eg n eten w ir H a n s Z im m erm an n , u n d d a m it w echselte u n se r K u rs.U n ser S ta n d o rt ließ sich n ic h t m eh r a u f ein er L a n d k a rte an g eb en .U nsere U hren d ie n te n zw ar im m er noch einem w ich tig en Z w eck; a b e r sie m u ß ten d u rch an d ere M ittel d er Z eitm essu n g e rg ä n z t w erden.U n d so zogen w ir m it H an s in den U rw ald , le rn te n die F am ilien M üller u n d F u m asoli k en n en , aßen v o m B au m des L ebens, k o rre sp o n d ie rte n m it S a n k t N iklaus u n d b e su c h te n d as M useum u n d d en Zoologischen G arten .N u n sind w ir am E n d e u n seres B erichtes, n ic h t a b e r am E n d e d e r R eise an g elan g t.D er O rt u n se re r L an d u n g , die T ageszeit, das K o rn , das w ir g esam m elt u n d die S p reu , die w ir w eggew orfen h aben, das alles g e h ö rt m it zu u n se re r R eise, weil es m it dem W eg zu sam m en h ä n g t, den w ir einschlugen u n d m it dem jenigen, den w ir je tz t u n d in Z u k u n ft einschlagen w erden.S ollte u ns je m a n d frag en : «S eid ih r m it einem einsam en M ädchen a u f einer S anddüne gewesen ?H a b t ih r m it einem ehem aligen S ü ch tig en G orgonzola gegessen ?H a b t ih r u n te r d em G esic h tsp u n k t von « Ü b e rtra g u n g » , « S e lb ste rk e n n tn is» , «A n g st» u n d « R e s e rp in » ü b e r die B esserung n a c h g e d a c h t? » , so k ö n n te n w ir m it j a a n tw o rte n .Z w ar k ö n n te n w ir n ich t sag en : « D a seh t her.W ir h a b e n h era u sg e fu n d e n , w as die B esserung in d er P sy c h o th e ra p ie is t u n d wie sie sich ä u ß e rn m u ß .»A ber w ir k ö n n te n sagen, d aß w ir d as P ro b lem zu uns h a b e n sp rech en lassen u n d uns m it ihm au s e in a n d e rg e se tz t h ab en .N ic h t, d a ß w ir alles h ö rte n , w as gesprochen w u rd e .« W enn es euch in te re s s ie rt» , k ö n n ten w ir sagen, « d a n n v e r s u c h t es doch selb st d a m it.»D en n w ir finden u ns alle im w esentlichen v o r die gleiche A ufgabe
Experimental Hepatocarcinogenesis
Journal: Hepatology (2013)

1.63; p<0.005), thyroid disease (HR 1.26; p<0.05),Crohn's disease (HR 1.55; p<0.005), psoriasis (HR 1.23; p<0.05) and inflammatory polyarthropathias (HR 1.32; CI 1.10-1.56;p<0.005), as compared to women without ICP.Women with diabetes mellitus seem to have an increased risk of ICP (OR 2.44; CI 0.95-6.28;p=0.634).Conclusions: Women with ICP have increased risk to be later diagnosed with autoimmune diseases, in particular diabetes mellitus, which is in agreement with our previous observation that women with ICP are more likely to have gestational diabetes.
Infection with Herpes-Simplex Viruses 1 and 2
Authors: André J. Nahmias, Bernard Roizman
Journal: New England Journal of Medicine (1973)

WE are currently in the middle of a new wave of research activity related to herpes-simplex viruses (HSV). The first period,* extending from about 100 A.D. to around 1920, contributed the clinical and pathological description of herpes febrilis (cold sores), herpes of the skin and herpes genitalis, and culminated in the isolation of the causative agent. The second period† — approximately 1920 to 1960 — began with the establishment of the rabbit cornea as a laboratory model for the study of viral pathogenesis. Gradually, as the experimental host range expanded to include other laboratory animals, chick embryos and ultimately cell . . .
Correction
Authors: J Willman, Mrs Bridie, Margaret Wilson, B Knight, J Anderton, M Beamish, T Hayes, Mr Edwards, Thomas Sellors, Mr Cox, Mr Morrissey, A Rains, N Stidolph, J Wade, Mr Salmon, G Coombes, Dnploma In, Patmoloovy.-S Adegbite, Allah Al-Douri, Chitrika De Silva
Journal: BMJ (1968)
CHEMICAL FEATURES OF MUSCULAR ATROPHY
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Global Infectious Disease
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract B43: Towards a Cancer Dependency Map
Authors: Aviad Tsherniak, Francisca Vazquez, Barbara Weir, Philip Montgomery, Glenn Cowley, Stanley Gill, Gregory Kryukov, Sasha Pantel, Will Harrington, Mike Burger, Robin Meyers, Levi Ali, Amy Goodale, Yenarae Lee, Levi Garraway, Jesse Boehm, David Root, Todd Golub, William Hahn
Journal: Clinical Cancer Research (2017)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR02) of the Conference Proceedings. Citation Format: Aviad Tsherniak, Francisca Vazquez, Barbara Weir, Philip Montgomery, Glenn Cowley, Stanley Gill, Gregory Kryukov, Sasha Pantel, Will Harrington, Mike Burger, Robin Meyers, Levi Ali, Amy Goodale, Yenarae Lee, Levi Garraway, Jesse Boehm, David Root, Todd Golub, William Hahn. Towards a Cancer Dependency Map. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr B43.
Infant Pulmonary Hemorrhage in a Suburban Home with Water Damage and Mold (Stachybotrys atra)
Authors: Susan M. Flappan, Jay Portnoy, Patricia Jones, Charles Barnes
Journal: Environmental Health Perspectives (1999)

The American Academy of Pediatrics recently issued guidelines regarding the potential toxic effect of indoor molds. We now report another case of an infant with pulmonary hemorrhage whose residential environmental assessment revealed the presence of the toxigenic mold Stachybotrys atra. We used a questionnaire to identify environmental factors that could predispose the home to fungal contamination. We collected air samples from multiple locations in the home that we felt would reflect areas of relevant exposure. Surface samples were collected with a piece of transparent tape for semiquantitative measurement of spores present. We classified spores into their respective genera based on shape, size, and color. We also measured mycotoxin levels. Air sampling revealed significantly elevated total spore counts in the patient's bedroom and in the attic. Aspergillus/Penicillium species were predominant. Stachybotrys spores were found in the air sampled in the patient's bedroom, as well as from surfaces sampled in the patient's closet and the attic ceiling. Additionally, a small patch of Stachybotrys-contaminated area in the closet ceiling was sent for mycotoxin analysis. This material proved to be highly toxigenic. As the link between the presence of Stachybotrys in the home and pulmonary hemorrhage in infants increases, further efforts should be made to educate physicians, health care providers, and new parents about the potential toxic effects of this mold.
Remission of metastatic adenocarcinoma of the colon
Authors: C. M. Shapiro
Journal: JAMA (1983)

TREATMENT of disseminated colon carcinoma must still be considered experimental.<sup>1</sup>Fluorinated pyrimidines, the cornerstone of treatment, yield only a 20% response rate and have had little impact on survival.<sup>1</sup>Immunotherapy with BCG vaccine has been reported to produce encouraging results in uncontrolled trials.<sup>2</sup>However, the role of immunotherapy in disseminated colonic cancer has yet to be established. We herein report a remission of a patient with metastatic adenocarcinoma of the colon treated with fluorouracil and BCG vaccine. <h3>Report of a Case</h3> A 30-year-old woman was initially seen at the Michael Reese Medical Center, Chicago, in 1967 (aged 18 years) with rectal bleeding. Her father had died of colon cancer at 45 years of age. Roentgenograms of the colon disclosed a mass lesion within the cecum, consistent with adenocarcinoma. An exploratory laparotomy confirmed the diagnosis, and a right-sided hemicolectomy was performed. The tumor extended into the muscularis. Lymph
Diabetic Retinopathy
Authors: H. J. Roberts
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In the paper by Winter on "Diabetic Retinopathy: Degenerative Vascular Complications of Diabetes and Discussion of Clinical Aspects of the Disease" (<i>JAMA</i><b>174</b>:143, 1960). I would take issue with the statement that, short of good diabetic control, nothing further can be done to treat or prevent this complication with the possible exception of hypophysectomy. For the past 4 years, I have given much attention to this problem for a number of patients having diabetic retinopathy both with and without active retinal bleeding. I am aware both of the wide variations in the natural course of this disorder (particularly with reference to the rate of resorption of intraocular bleeding) and of the justifiable skepticism directed at any therapeutic approach. However, I have found the following points helpful: 1. Rubbing of the eyes is strongly contraindicated. 2. Smoking is contraindicated. 3. Hypoglycemia must be prevented or minimized. Patients
Thyroid Hormone Antagonizes Tumor Necrosis Factor-α Signaling in Pituitary Cells through the Induction of Dual Specificity Phosphatase 1
Authors: Marina Lasa, Beatriz Gil-Araujo, Marta Palafox, Ana Aranda
Journal: Endocrine Reviews (2010)

Pituitary function has been shown to be regulated by an increasing number of factors, including cytokines and hormones, such as TNFα and T3. Both the proinflammatory cytokine TNFα and T3 have been suggested to be involved in the maintenance of tissue homeostasis in the anterior pituitary gland. In this report we show that T3 negatively interferes with MAPK p38 and nuclear factor-κB (NF-κB) activation by TNFα in GH4C1 cells. Our data demonstrate that MAPK p38 is specifically activated upon exposure to TNFα and that T3 abolishes this activation in a time-dependent manner by a mechanism that involves the induction of the MAPK phosphatase, DUSP1. Our data show that the pool of up-regulated DUSP1 by T3 is mainly localized to the cytosol, and that TNFα does not affect this localization. On the other hand, we show that T3 impairs the activation of the NF-κB pathway induced by TNFα, producing a significant decrease in NF-κB-dependent transcription, phosphorylation of IκBα, translocation of p65/NF-κB to the nucleus, and p65/NF-κB transactivation potential. Interestingly, the overexpression of DUSP1 inhibits the NF-κB activation achieved by either TNFα or ectopic expression of the upstream inducer of MAPK p38. Conversely, DUSP1 depletion abrogates the inhibitory effect of T3 on the induction of NF-κB-dependent transcription by TNFα. Overall, our results indicate that T3 antagonizes TNFα signaling in rat pituitary tumor cells through the induction of DUSP1.
Improved cholesterol-related knowledge and behavior and plasma cholesterol levels in adults during the 1980s
Authors: E. Frank
Journal: JAMA (1992)

<h3>Objectives.</h3> —To determine whether cholesterol-related knowledge and behavior and plasma cholesterol levels were stable until the inception of large-scale national interventions in the middle to late 1980s, whether they subsequently improved, and whether these levels varied by subgroups. <h3>Design, Setting, and Participants.</h3> —Data were collected from 4173 adults aged 25 through 74 years in the two control cities (San Luis Obispo and Modesto, Calif) of the Stanford Five-City Project. Five separate, community-based surveys were conducted in 1979-1980,1981-1982,1983-1984,1985-1986, and 1989-1990. <h3>Results.</h3> —Cholesterol-related knowledge and behavior and plasma cholesterol levels improved (<i>P</i>=.0001) in both cities after the early 1980s. Those who were more educated, female, older, or nonsmokers had significantly higher knowledge and behavior scores, and those who were younger, more educated, or normotensive had significantly lower plasma cholesterol levels. <h3>Conclusion.</h3> —Improvements in this population's cholesterol-related knowledge and behavior and plasma cholesterol levels began in 1985-1986, suggesting that the extensive cholesterol interventions that began in the middle 1980s in the United States created positive cholesterol-related changes at the community level. (<i>JAMA</i>. 1992;268:1566-1572)
Medical communication via satellite
Authors: B. J. Montgomery
Journal: JAMA (1978)

Obtaining consultation can be a major problem for physicians working in an area with 22% of the US land mass, five time zones, and less than 5% of the population. Cable television communication has been used in some portions of the nation, but since that method relies on radio waves, broadcasting is impossible in much of the Far West when inclement weather or mountain ranges intervene. The answer may lie partly in the satellite communication and television broadcasting headquartered at the University of Washington in Seattle. Since 1974 the university, which has the only medical school in the states of Washington, Alaska, Montana, and Idaho (WAMI), has conducted more than 350 broadcasts designed to test the feasibility of transmitting biomedical information, including continuing medical education courses, via satellite. Lack of specialists is a common type of problem that has been tackled. For example, at one point there was no dermatologist
Abstract 3555: miR-374a-5p induces tumor progression in triple negative breast cancer
Authors: Yesol Kim, Dasom Son, Do Yeon Kim, Jong Hoon Park
Journal: Cancer Research (2019)

Abstract Triple negative breast cancer (TNBC) has higher aggressiveness and poorer outcomes compared with other subtypes of breast cancer. However, the genomic and molecular aberrations of TNBC are largely unknown, with cytotoxic chemotherapy remaining the major treatment for TNBC patients. In this study, miR-374a-5p was discovered as a novel TNBC-specific miRNA and its functions and the molecular mechanisms involved were investigated. Combined gene expression profiling of miRNA-microarray and human transcriptome dataset analysis revealed that miR-374a-5p is specifically upregulated in TNBC patients. Functional studies using in vitro and in vivo TNBC models, as well as survival analysis of TNBC patients, indicated that upregulated miR-374a-5p promotes tumor progression in TNBC. miR-374a-5p was also found to directly target arrestin beta 1 (ARRB1) that is specifically downregulated in TNBC patients in several human genomic datasets. Overexpressed ARRB1 reduced TNBC cell growth and migration, and the ARRB1 expression level is inversely correlated with the histological grade of the breast cancer and positively associated with TNBC patient survival, suggestive of a tumor-suppressive function of ARRB1 in breast cancer. Interestingly, increased ARRB1 activates AMPK in TNBC cells, which is associated with the expression of miR-374a-5p. Taken together, the findings suggest that miR-374a-5p is a novel prognostic marker and therapeutic target in the treatment of TNBC. Citation Format: Yesol Kim, Dasom Son, Do Yeon Kim, Jong Hoon Park. miR-374a-5p induces tumor progression in triple negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3555.
Incorrect Units in Methods
Journal: JAMA Oncology (2015)

Lauren C. Harshman, MD; Xiaodong Wang, PhD; Mari Nakabayashi, MD; Wanling Xie, MS; Loana Valenca, MD; Lillian Werner, MS; Yongjiang Yu, PhD; Aaron M. Kantoff, BS; Christopher J. Sweeney, MBBS; Lorelei A. Mucci, ScD; Mark Pomerantz, MD; Gwo-Shu Mary Lee, PhD; Philip W. Kantoff, MD
The hazards of involuntary smoking in the restaurant workplace
Authors: G. Robertson
Journal: JAMA (1994)

<h3>In Reply.</h3> —I appreciate Mr Robertson's comments and agree that findings from my review support his 1988 survey finding that ETS levels in restaurants are about 1.5 times higher than in offices. Since Healthy Buildings International contributed much of the important data I reviewed, these comments add valuable support to the finding of increased ETS exposure for restaurant workers. However, Robertson inaccurately interprets how I concluded that the 50% excess lung cancer risk among food service workers is most likely attributable to this increased ETS exposure. This conclusion was not based on the coincidental finding that the ratio of ETS levels in restaurants compared with offices and the ratio of lung cancer risk among food service workers compared with other workers were both about 1.5. Rather, it was based on my review of the possible explanations for the consistent finding of an elevated lung cancer risk among food service workers.
Sequence Specificity of Mutagenesis in the cI Gene of Bacteriophage Lambda
Authors: T. R. Skopek, R. D. Wood, F. Hutchinson
Journal: Environmental Health Perspectives (1985)

Studies of DNA base sequence alterations have shown that for every agent the mutagenic process is specific with respect to the types of base changes induced and the location of the changes in the DNA. Analysis of the types of mutations produced by mutagenic agents can provide insight into the mechanism of mutation and can suggest which DNA lesions may be involved in the actual mutagenic event. We have developed a system for the analysis of chemically induced base sequence alterations in the cI repressor gene of bacteriophage lambda using DNA sequencing techniques. To illustrate the utility of this type of analysis, we present the results obtained with ultraviolet light (UV). Irradiation of target DNA with UV alone, or UV followed by photoreactivating light (which removes dimers), produces mostly transitions at pyrimidine-pyrimidine sites. Conversely, irradiation with 313 nm light plus acetophenone (which produces only thymine dimers) produces mostly transversions at low efficiency. This and other evidence suggests that the actual premutagenic UV lesion in E. coli may not be pyrimidine-pyrimidine dimers, but rather pyr(6-4)pyo photoproducts.