tbuckley/cabot-search huggingface dataset:
The ninth report of the Human Renal Transplant Registry
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Placenta — Fetus: Inseparable Functions Coming to Light
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DANGER FROM SURGERY.
Journal: JAMA (1902)

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Deutsche Medizinische Wochenschrift, Stuttgart
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification, incidence and clinical outcomes of patients (pts) with hypermutated prostate cancer (PC).
Authors: Simon Yuen Fai Fu, Elie Ritch, Steven Yip, Daniel Khalaf, Sinja Taavitsainen, Matti Annala, Gillian Vandekerkhove, Igal Kushnir, Sebastien J. Hotte, Cristiano Ferrario, Alexander William Wyatt, Kim N. Chi
Journal: Journal of Clinical Oncology (2019)

195 Background: A small proportion of metastatic PC exhibit outlier somatic mutation rates. The incidence, clinical course and treatment response of pts with hypermutation (HM) is poorly characterised. Methods: We performed targeted sequencing of 1047 plasma cell-free DNA samples and calculated somatic mutation burden. HM samples and available matched archival tissue were additionally subjected to whole exome sequencing. Trinucleotide mutational signatures and microsatellite instability (MSI) were determined via nonnegative matrix factorization and mSINGS, respectively. We evaluated PSA decline ≥50% from baseline (PSA50), time from androgen deprivation therapy (ADT) to castration-resistant prostate cancer (CRPC), median duration of 1 st line CRPC therapy (1L CRPCT) and median OS (time from CRPC to death). The control cohort consisted of 199 CRPC pts treated with 1L abiraterone + prednisone (ABI+P) or enzalutamide (ENZ). Results: 671 samples from 434 pts had ctDNA% &gt; 2 and were evaluable. The median mutation rate was 2.59/Mb (range, 0.9 – 155.6/Mb). 32 samples from 24 pts had &gt; 11/Mb and fell above the 95 th percentile for mutational burden. 10/24 pts had biallelic loss of mismatch repair (MMR) genes MSH2/6, and a further 5 pts without confirmed MMR defects had enrichment of trinucleotide signatures associated with MMR and/or were MSI high by mSINGS. The remaining 9 pts had either BRCA2 mutations or Kataegis (localized hypermutation). Clinical data was available for 10/15 MMR defective pts. Median age was 73.6 y. At diagnosis, 70% had Gleason score ≥8, 50% with M1 disease, median PSA was 22.8 (6.8 – 820). PSA50 with ADT (n = 8) or ADT + docetaxel (n = 2) was 100% in the castration sensitive setting. 5 pts had ENZ, 4 ABI + P, and 1 cabazitaxel in 1L CRPCT. Comparing the MMR defective with the control cohort, median time from ADT to CRPC was 9.1 m (95% CI 6.9 – 11.4) vs. 18.2 m (95% CI 15.1 – 21.3), p = 0.001; 1L CRPCT duration was 3.9 m (95% CI 1.3 – 6.5) vs. 8.4 m (95% CI 7.2 – 9.6), p = &lt; 0.001; median OS was 13.1 m (95% CI 0.33 – 25.9) vs. 40.1 m (95% CI 32.4 – 47.8), p &lt; 0.001. Conclusions: HM and MMR defects can be identified in a liquid biopsy. Although these pts can have poor outcomes with standard therapy, ctDNA may help selection for immunotherapy.
Abdominal Aortography
Authors: Owins W. Kincaid, George D. Davis
Journal: New England Journal of Medicine (1958)

THE development of surgical methods for the management of diseases of the heart and blood vessels ranks as one of the outstanding medical achievements of the past decade. It is unlikely, however, that these advances in cardiovascular surgery would have come about without parallel advances in medical diagnosis, not the least important of which has been the development of angiography as an accurate and safe method of investigation of diseases of the vascular system.There are today few major vessels and organs in the body that cannot be investigated by means of angiography. Cerebral angiography, angiocardiography, thoracic and abdominal aortography, . . .
Combination of amikacin and carbenicillin with or without cefazolin as empirical treatment of febrile neutropenic patients. The International Antimicrobial Therapy Project Group of the European Organization for Research and Treatment of Cancer.
Journal: Journal of Clinical Oncology (1983)

A total of 841 febrile neutropenic patients from 20 centers were randomized to receive carbenicillin (or ticarcillin) plus amikacin or these antibiotics plus cefazolin to compare outcome and incidence of nephrotoxicity. Infection with Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, or Staphylococcus aureus accounted for most of the microbiologically documented febrile episodes. The response to therapy was similar in the two treatment groups for all infections and for bacteremia. Improvement occurred in 35 (64%) of 55 bacteremic patients treated with two antibiotics and 39 (65%) of 60 treated with three antibiotics. An increase in serum creatinine to 2 mg/dL over baseline occurred in eight (2.1%) of 381 patients in the former and in 50 (2.4%) of 364 patients in the latter group. Thus, the two antibiotic regimens were equal in efficacy and in nephrotoxicity. Although not the primary focus of this study, a significant decrease in incidence of infection, including bacteremias, was found in neutropenic patients treated with any oral intestine decontamination regimen.
Preoperative anaesthetic visit.
Journal: BMJ (1977)

standing of the reporting systems involved.On the one hand there are the cases of "paralytic poliomyelitis" notified by the clinicians to the Department of Health and Social Security.'There may or may not be virus isolates from these patients.Secondly, there are the weekly reports of the virus isolates from diagnostic laboratories.2The clinical information submitted with these Communicable Disease Reports is necessarily preliminary and the subsequent course of the illness frequently causes revision of the diagnosis.This is verified by the Epidemio- logical Research Laboratory when these reports are correlated with the official notifica- tions for the annual poliomyelitis surveillance report.The correct figure obtained in this way
Last Hope
Authors: H J. Van Peenen
Journal: Annals of Internal Medicine (2001)

Ad Libitum20 November 2001Last HopeH J. Van Peenen, MDH J. Van Peenen, MDPonca City, OK 74604Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-10-200111200-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Heart, the capital city, when informedthat death was at the palace gates,hauled his standard down.He could no longer count on his defenders,those lounging bodyguards, lungs, kidneys, eyes,already conniving to remain alive.Go! May young ... Author, Article, and Disclosure InformationAuthors: H J. Van Peenen, MDAffiliations: Ponca City, OK 74604Corresponding Author: H.J. Van Peenen, MD, 1414 East Hartford, Unit #9, Ponca City, OK 74604. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 November 2001Volume 135, Issue 10Page: 926KeywordsBrainCardiovascular therapyCorneaHeartHeart diseasesKidneysLungsOxygenSleep ePublished: 20 November 2001 Issue Published: 20 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Department of Public Health.
Authors: W. M. Smith
Journal: JAMA (1895)

East Las Vegas, N. M., Nov. 5, 1895. <h3>To the Editor:</h3> —Will you please inform me where I can get a copy of the bill drawn up by a committee of theAmerican Medical Associationfor the establishment of a department of public health? Yours very truly, <h3>Answer:</h3> —Write the Chairman of the Committee, Dr. Jerome Cochran, State Health Officer, Montgomery, Ala.
Elucidation of Catalytic Specificities of Human Cytochrome P450 and Glutathione S-Transferase Enzymes and Relevance to Molecular Epidemiology
Authors: F. Peter Guengerich, Tsutomu Shimada, Kevin D. Raney, Chul-Ho Yun, David J. Meyer, Brian Ketterer, Thomas M. Harris, John D. Groopman, Fred F. Kadlubar
Journal: Environmental Health Perspectives (1992)

A number of different approaches have been used to determine the catalytic selectivity of individual human enzymes toward procarcinogens. Studies with cytochrome P450 (P450) enzymes and glutathione S-transferases are summarized here, and recent work with pyrrolizidine alkaloids, aflatoxins, 4,4'-methylenebis(2-chloroaniline), and ethyl carbamate is discussed. In some cases a single enzyme can catalyze both activation and detoxication reactions of a chemical. The purification and characterization of human lung P4501A1 and the development of a noninvasive assay for human P4502E1 are also described.
Xanthoma Tuberosum Multiplex. Complete Recovery with Cholesterol-Lowering Diet
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Reports.—1.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Fate of Enzymes in Body Fluids: Disappearance Rates of Glutamic-Pyruvic Transaminase under Various Conditions
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgical Management of Tumors that Produce Gastrointestinal Hormones
Authors: C. Townsend
Journal: Annual Review of Medicine (1985)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More
Hyperbaric oxygen toxicity prevention with succinate
Authors: A. P. Sanders
Journal: JAMA (1968)

Succinate protection against oxygen toxicity in rats was investigated at oxygen pressures of 5, 7, 9, and 11 atmospheres absolute (atm abs), and compared with protection given by dextrose and malate. Times to convulsions were used for comparison. Dextrose and malate gave no protection. Succinate provided relatively long-term protection at 5 and 7 atm abs oxygen exposures, but showed decreasing protection with increasing pressure. Succinate provided no protection at oxygen pressures of 12 atm abs or higher. A 3:1 sodium succinate:ammonium succinate mixture (0.4M, pH 7.4) solved the problem of alkalosis previously encountered with a sodium succinate solution. The infusion of the 3:1 mixture (6 millimols/kg/hr) in dogs exposed to 5 atm abs oxygen delayed convulsion 5 to 11 times longer than in controls. Intracellular localization and thin layer chromatography studies with succinate-2, 3<sup>14</sup>C showed that succinate readily penetrated the blood brain barrier.
SAT0365 Secular trends in the incidence and prevalence of gout in denmark from 1995–2015: a nationwide register-based study
Authors: K. Zobbe, D. Prieto-Alhambra, R. Cordzt, P. Højgaard, J.S. Hindrup, L.E. Kristensen, L. Dreyer
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Gout is percieved as the most prevalent inflammatory arthritis in the western world – but with great regional and ethnical variation. The incidence and prevalence is thought to be increasing but it's based on few population studies with limited calendar time periods.[<sup>1</sup> We took advantage of the unique Danish health registries to examine the incidence and prevalence of gout in a nationwide cohort covering the last two decades. <h3>Objectives</h3> To examine temporal trends in the incidence and prevalence of gout in the adult Danish population. <h3>Methods</h3> Using the nationwide Danish National Patient Registry (DNPR), we calculated the incident rate of hospitalised gout patients (per 1 00 000 person-years) within each 1 year period from 1995 to 2015, and prevalence of gout requiring hospitalisation in 2000 and 2015. Additionally, the age- and gender-specific incidence rates of gout from 1995 to 2015 were calculated. Incidence rates were standardised according to the NORDCAN standard population. Confidence intervals (CI) were calculated according to a Poisson distribution. Both incidence rates based on diagnosis from all specialties and rheumatologists, respectively, were calculated. <h3>Results</h3> In the 20 year study period we identified 45 685 newly diagnosed cases of gout. We found an increase in overall incidence, from 32.26/100,000 [95%CI 30.7 to 33.1] in 1995 to 57.5/100,000 [95%CI 55.6 to 59.5] in 2015(p&lt;0.001). The age and sex specific incidence rates increased progressively with increasing age among both sexes, most markedly in patients aged &gt;60 years. Similar trends were observed for cases diagnosed at rheumatology departments. We likewise observed an increase in the prevalence of gout from 0.29% [95%CI 0.29 to 0.30] in 2000 to 0.68% [95%CI 0.68 to 0.69] in 2015. <h3>Conclusions</h3> We found a 1.8-fold increase in the incident rate of hospitalised gout patients in the period 1995–2015 in Denmark among both men and women. Similarly we found a 2.2-fold increase in the prevalence from 2000 to 2015. Further research is needed to elucidate the causes underlying the observed increase in the burden of gout in Denmark <h3>Reference</h3> [1] Kuo C-F, Grainge MJ, Zhang W, et al. Global epidemiology of gout: prevalence, incidence, and risk factors. Nat Rev Rheumatol2015;11:649–62. doi:10.1038/nrrheum.2015.91 <h3>Disclosure of Interest</h3> K. Zobbe: None declared, D. Prieto-Alhambra Grant/research support from: Amgen, Servier, and UCB, Speakers bureau: Amgen, R. Cordzt: None declared, P. Højgaard: None declared, J. Hindrup Consultant for: Berlin-Chemie Menarini and Grünenthal, L. E. Kristensen Grant/research support from: UCB, Biogen, Janssen pharmaceuticals, and Novartis, Speakers bureau: Pfizer, AbbVie, Amgen, UCB, BMS, Biogen, MSD, Novartis, Eli Lilly and Company, and Janssen pharmaceuticals, L. Dreyer: None declared
Huge Toll From Nonfatal Injuries
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal