Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndrome in HLA-Identical Siblings
Authors: RICHARD M. HELLMAN, DON V. JACKSON, DAVID H. BUSS
Journal: Annals of Internal Medicine (1980)

Brief Reports1 August 1980Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndrome in HLA-Identical SiblingsRICHARD M. HELLMAN, M.D., DON V. JACKSON, M.D., DAVID H. BUSS, M.D.RICHARD M. HELLMAN, M.D.Search for more papers by this author, DON V. JACKSON, M.D.Search for more papers by this author, DAVID H. BUSS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-283 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThrombocytopenia, microangiopathic hemolytic anemia, and renal failure are features common to both hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura, with neurologic disturbances being more frequently observed in the latter disorder. The causes of these syndromes are unknown. Neither the occurrence of hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura in the same family nor tissue-typing using the HLA system in siblings with these disorders has been previously reported. The cases described below occurred 6½ years apart in HLA-identical brothers. Although features of these two cases appear sufficiently different to allow separation into thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome, the unique occurrence in brothers...References1. UMLASKAISER JJ. Thrombohemolytic thrombocytopenic purpura (TTP): a disease or a syndrome? Am J Med. 1970;49:723-8. CrossrefMedlineGoogle Scholar2. WALLACELOVRICCLUBBCARSELDINE DAJD. Thrombotic thrombocytopenic purpura in four siblings. Am J Med. 1975;58:724-34. CrossrefMedlineGoogle Scholar3. FUCHSGEORGEDOTINSEARS WJLD. Thrombotic thrombocytopenic purpura: occurrence two years apart during late pregnancy in two sisters. JAMA. 1976;235:2126-7. CrossrefMedlineGoogle Scholar4. KARLSBERGLACHERBARTECCHI RJC. Adult hemolytic-uremic syndrome: familial variant. Arch Intern Med. 1977;137:1155-7. CrossrefMedlineGoogle Scholar5. CHANELEFFCAMPBELL JMR. The hemolytic-uremic syndrome in nonrelated adopted siblings. J Pediatr. 1969;75:1050-3. CrossrefMedlineGoogle Scholar6. WATSONCOOPER CW. Thrombotic thrombocytopenic purpura: concomitant occurrence in husband and wife. JAMA. 1971;215:1821-2. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bowman Gray School of Medicine Winston-Salem, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEmerging Concepts in Immune Thrombotic Thrombocytopenic PurpuraThrombotic thrombocytopenic purpuraIncreased Fragmentation of von Willebrand Factor, Due to Abnormal Cleavage of the Subunit, Parallels Disease Activity in Recurrent Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura and Discloses Predisposition in FamiliesIncreased Fragmentation of von Willebrand Factor, Due to Abnormal Cleavage of the Subunit, Parallels Disease Activity in Recurrent Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura and Discloses Predisposition in FamiliesRenal transplantation in adults with autosomal recessive inheritance of hemolytic uremic syndromeHaemolytic—Uraemic Syndrome and Thrombotic Thrombocytopenic PurpuraThrombotic Thrombocytopenic Purpura and Related DisordersThe Hemolytic Uremic SyndromesHaemolytic Uraemic Syndrome and Thrombotic Thrombocytopenic Purpura: A ReviewHematologic DiseasesThrombocytopenia Due to Non-immune Platelet DestructionIneffectiveness of Aspirin and Dipyridamole in the Treatment of Thrombotic Thrombocytopenic PurpuraMICHAEL H. ROSOVE, M.D., WINSTON G. HO, M.D., DENNIS GOLDFINGER, M.D. 1 August 1980Volume 93, Issue 2Page: 283-284KeywordsHemolytic anemiaHemolytic-uremic syndromeHuman leukocyte antigenImmunologyMicrobiologyRenal failureThrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 August 1980 PDF downloadLoading ...