tbuckley/cabot-search huggingface dataset:
Report of the Federal Panel on Formaldehyde
Authors: Richard Griesemer, Andrew Ulsamer, Joseph Arcos, James Beall, Aaron Blair, Thomas Collins, Freder- Ick De Serres, David Groth, Han Kang, Richard Keenlyside
Journal: Environmental Health Perspectives (1982)

Report of the Federal Panel on Formaldehyde*The Federal Panel on Formaldehyde concluded that definitive experiments exist which demonstrate the mutagenicity and carcinogenicity of formaldehyde under laboratory conditions.Formaldehyde induces both gene mutations and chromosomal aberrations in a variety of test systems.Inhalation of formaldehyde causes cancer of the nose in rats.The concentrations of formalde- hyde in inhaled air that caused nasal cancer in Fisher 344 rats are within the same order of magnitude as those to which humans may be exposed.The data presently available do not permit a direct assessment of the carcinogenicity of formaldehyde to man.Epidemiologic studies on exposed human populations are in progress and may further clarify the situation.Other experimental and human studies on toxic effects such as teratogenicity and reproductive disorders are as yet inadequate for a health risk assessment.The CIIT 24 month study on animal carcinogenicity has not yet been completely evaluated.Additional data are expected on the effects of prolonged exposure to lower doses of formaldehyde and on the possible carcinogenicity of formaldehyde in the mouse.The panel recommends that, for a comprehensive health risk assessment, further experiments be conducted on the effects of other modes of exposure (ingestion and skin penetration), the effects in humans, and on the pharmacokinetics of formaldehyde in man and animals and the possible role for formaldehyde in reproductive and chronic respiratory disorders.It is the conclusion of the panel that formaldehyde should be presumed to pose a carcinogenic risk to humans.
Penicillin-induced immune hemolytic anemia. Occurrence of massive intravascular hemolysis
Authors: C. A. Ries
Journal: JAMA (1975)

A patient with penicillin-induced immune hemolytic anemia had massive intravascular hemolysis with hemoglobinemia and hemoglobinuria. Substantial amounts of complement components C3 and C4 were detected on the patient's red blood cells (RBCs), in addition to the usual IgG antibody to penicillin. The patient's serum demonstrated a high titer of antibody to penicillin (8,000), which did not cause hemolysis in vitro, but did cause complement fixation when incubated with normal serum. The presence of complement components on the patient's RBCs, and the finding that the serum fixed complement in vitro suggests that penicillin-antipenicillin immune complexes may have been present in the serum. We attribute the severity of the hemolysis to participation of the complement system in the hemolytic process and to the high titer of antibody to penicillin. (<i>JAMA</i>233:432-435, 1975)
“Dead space: the physiology of wasted ventilation.” H. Thomas Robertson. Eur Respir J 2015; 45: 1704–1716.
Journal: European Respiratory Journal (2015)

We regret that several typographical errors were introduced to the final published version of this article.The term PACO 2 (to indicate alveolar carbon dioxide tension) was presented incorrectly as PaCO 2 (used in the article to indicate arterial carbon dioxide tension).Also, the second equation on page 1705 was presented incorrectly as
THE HUMBLE HERNIA
Authors: J. H. T.
Journal: JAMA (1961)

LESS than three-quarters of a century ago, the chances were meager for a permanently satisfactory result from the repair of an indirect inguinal hernia. The correction was temporary in most instances, and the patient probably reverted to a truss to compress the walls of the dilated inguinal canal. Such disappointing consequences attracted the attention of some of the best surgeons in Europe and America. As prosaic a subject as the inguinal hernia might have been delegated to mediocre minds with suboptimal skills for solution. This was not the fate in the historical development of the surgical technique as recorded by Ravitch of Johns Hopkins University and the Baltimore City Hospitals. The essays on the history of the hernia, prepared with the assistance of Hitzrot his resident in orthopedic surgery, were published last fall in two issues of<i>Surgery</i>.<sup>1</sup>They have been reprinted and bound as a monograph with an
A phase II open-label, multicenter study of single-agent rucaparib in the treatment of patients with relapsed ovarian cancer and a deleterious BRCA mutation.
Authors: Ronnie Shapira-Frommer, Amit M. Oza, Susan M. Domchek, Judith Balmaña, Manish R. Patel, Lee-may Chen, Yvette Drew, Howard A. Burris, Jacob Korach, Michael Flynn, Valerie Lydia Bowering, Mark Aloysuis Morgan, Simon Paul Watkins, Dayna Simpson, Sandra Goble, Lara Maloney, Rebecca Sophie Kristeleit
Journal: Journal of Clinical Oncology (2015)

5513 Background: Rucaparib is a potent oral PARP inhibitor that has shown robust activity in patients (pts) with homologous recombination deficient (HRD) tumors, with the highest response rates observed in ovarian and breast cancer pts harboring deleterious germline BRCA mutations (gBRCAmut). This phase II study (NCT 01891344) evaluated the efficacy and safety of rucaparib in pts with relapsed gBRCAmut high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer (EOC/FTC/PPC). Methods: Women with gBRCAmut EOC/FTC/PPC who received 2-4 prior chemotherapy (chemo) regimens and had a progression-free interval (PFI) ≥ 6 months after their last platinum dose were enrolled. ECOG PS 0-1 and adequate organ function were required. Pts received oral rucaparib 600 mg BID in 21 day cycles until disease progression. The primary endpoint was objective response rate (ORR) by RECIST 1.1. Results: 35 pts have been enrolled. Median age was 55 years (range 44-84). The median number of prior chemo regimens was 2 (range 2– 4). Fifteen pts (43%) had received ≥ 3 prior chemo regimens. RECIST/CA-125 ORR was 81% (21/26); RECIST ORR was 65% (17/26). RECIST ORR was 88% (7/8) and 56% (10/18), respectively, in pts with PFI 6-12 mo or > 12 mos. In pts with ≥ 3 prior chemo regimens, 58% (7/12) achieved a RECIST response. The median duration of response and PFS have not been reached. The most common treatment-related AEs (generally grade 1/2) were nausea (55%), anemia (41%), ALT/AST elevations (41%), fatigue (41%), and asthenia (35%). The ALT/AST elevations are transient with no other evidence of liver dysfunction. No pts discontinued treatment due to an AE. No secondary malignancies have been observed. Conclusions: Rucaparib demonstrated robust activity in heavily pretreated EOC/FTC/PPC pts with gBRCAmut tumors with 81% of pts achieving RECIST/CA-125 responses. Rucaparib was well tolerated and AEs did not result in any treatment discontinuations. The ongoing pivotal program in EOC/FTC/PPC pts is evaluating rucaparib in treatment (ARIEL2, NCT01891344) and maintenance (ARIEL3, NCT01968213) settings. Clinical trial information: NCT01891344.
DEMONSTRATION OF CAPSULE-LIKE APPEARANCE IN STAINING GONOCOCCI
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poliomyelitis
Authors: J. E. Elam
Journal: BMJ (1947)

Poliomyelitis SIR,-In your leading article on poliomyelitis (July 26, p. 135) you do not mention swimming and diving in sewage-polluted rivers as a cause of infection.'When will the people of this country understand that if they will turn sewage into our rivers and then bathe in thern they must expect trouble.Again and again we see cases of infantile paralysis appearing in farms and villages on the banks of polluted rivers.The virus is present in faeces and then passes through sewage into rivers.Young people bathe in sewage-polluted rivers, and we wonder why they get infantile paralysis.-Iam, etc., New Barnet, Hens.
European Medicines Agency updates on the review of Pandemrix and reports of narcolepsy
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2010)

Preview this article: European Medicines Agency updates on the review of Pandemrix and reports of narcolepsy, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/38/art19670-en-1.gif
Pathophysiology and General Management of Patients with Massive Blood Loss
Authors: Augusto B. Federici, Daniele Prati
Journal: HemaSphere (2018)

1Hematology and Transfusion Medicine, L. Sacco University Hospital, Department of Oncology and Hematology Oncology, University of Milan 2Department of Transfusion Medicine, Fondazione IRCCS Cá Granda Ospedale Maggiore Policlinico, Milan, Italy This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
PERMANENT DUTIES FOR THE ANNUAL MEETINGS.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
'Dramatic' Treatment For Obesity; Diseased Patients Test Starvation
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blueprint for the future
Authors: W. C. Bornemeier
Journal: JAMA (1971)

Today I should like to review briefly some of the recommendations that I have made to this House of Delegates and some facts and figures that I have emphasized in talking to the public during the past year. Then I will outline what I believe to be the blueprint for the future of medical practice in this country. Many things have been said and written about manpower. I have told the public over and over that medical school enrollment is being doubled in many areas and increased in all areas, that by the end of this decade we hope to have enough doctors to provide medical care to every area of the country. Some recently published data seem to indicate that we are still not moving fast enough. According to an article in the June 14 issue of<i>U.S. News &amp; World Report</i>, the population down-trend has been reversed by
Lactate dehydrogenase isoenzymes in alveolar proteinosis
Authors: F. F. Fountain
Journal: JAMA (1969)

<h3>To the Editor:—</h3> "The Package Insert" letter is appropriate. Inquiries reveal that most pharmacists discard the package inserts when dispensing. Who reads them?! Descriptive drug literature regarding side effects and complications are often not carefully read, since there is a superabundance of this type of mail.
Book reviews
Journal: Allergy (1989)

Book reviews in this articles: Witte, O. N., Klinman, N. R. &amp; Howard, M. C.(eds.): B cell development. Davies, R. J. &amp; Ollier, S.: Allergy: the facts. Potter, M. &amp; Melchers, F. (eds.): Mechanisms in B‐cell neoplasia 1988.
Doctors and television.
Authors: D Fairweather, Blanche Alter, D Nathan, D Loukopoulos, J Clegg, J Weatherall
Journal: BMJ (1978)

of carrying a fetus with homozygous r-thalassaemia.A presumptive diagnosis of homozygous P-thalassaemia was made in four cases, and the pregnancy was termina- ted.An inconclusive answer was obtained in one case, and the patient also chose to have her pregnancy termina- ted.Two fetuses were lost as a result of the procedure.Of the remaining 15 pregnancies, 13 proceeded to term and two to 36 weeks; in each case a normal infant or one heterozygous for r-thalassaemia was delivered.Current efforts should be directed towards improving the blood sampling technology so that fetal blood sampling can be used widely in those countries where thalassaemia is a major problem.
Recognising macrophage activation syndrome
Journal: Annals of the Rheumatic Diseases (2002)

Background: Juvenile idiopathic arthritis (JIA) is strongly associated with the DR8-DQ4 haplotype.The genes encoding DR8 and DQ4 are in strong linkage disequilibrium (LD) and occur together on the same HLA haplotype in almost all patients and controls.Because of the strong LD it is not clear whether DR8, DQ4, or both, are primarily associated with JIA.Objective: To unveil the primary association of JIA-that is, with DR8 or DQ4.Methods: DRB1, DQA1, and DQB1 alleles of 585 Norwegian and 47 Polish unrelated patients with JIA (categorised as pauciarticular and rheumatoid factor negative polyarticular JIA), and of 3155 Norwegian and 158 Polish unrelated controls, were typed using a polymerase chain reaction or oligonucleotide hybridisation and sequence-specific primers method.Results: Several haplotypes which encoded DR8 (that is, carried DRB1*08) and which did not encode DQ4 (that is, did not carry DQA1*0401) were found.Such haplotypes were found in three Norwegian patients and two controls (p=0.029).In the Polish population such haplotypes were found among four patients with JIA and two controls (p=0.025).No haplotypes which carried DQA1*0401 and DQB1*0402 in the absence of DRB1*08 were found, either among patients with JIA (Polish and Norwegian) or among the controls (Polish).Conclusion: On the DR8-DQ4 haplotype the DRB1*08 allele is primarily associated with JIA.
The Grant Method in the Surgery of Epithelioma of the Lip
Authors: W. W. Grant
Journal: JAMA (1913)

<h3>To the Editor:</h3> —InThe Journal(Feb. 15, 1913, p. 507) is an article on "Operation for Epithelioma of the Lower Lip," by Dr. H. A. L. Ryfkogel of San Francisco. The operation is described as not being new, but as having been developed in Dr. Ryfkogel's service by combining the methods of other operators. Kindly permit me to say that the diagrams and descriptive formation of flaps are a reproduction of my original operation for "Cancer of the Mouth," first published in the<i>Medical Record</i>, New York, March, 1899, and more fully elaborated, illustrated and read before the Section on Surgery of the American Medical Association in July, 1905, at Portland, Ore. It was published inThe Journal, Sept. 30, 1905, p. 962, It is of course possible that Dr. Ryfkogel never read this article.
Periodic Measurement of N-Telopeptides of Type I Collogen in Serum (SNTX) for Early Diagnosis of Bone Metastasis in Patients with Lung Cancer
Authors: H. Daga, M. Tamiya, S. Tokunaga, K. Taira, H. Okada, H. Suzuki, N. Okamoto, N. Morishita, T. Hirashima, K. Takeda
Journal: Annals of Oncology (2012)
Life Interrupted
Authors: Raghav Chawla
Journal: BMJ (2004)

An exhibition of photographs by Don McCullin about HIV and AIDS, County Hall Gallery, London, until 10 January 2005 (open Friday to Sunday only), admission free The exhibition will tour the UK and Ireland throughout 2005. See http://www.christian-aid.org.uk/ for further details Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> W ords and figures are not enough to describe the suffering that is caused by the AIDS pandemic. In his new exhibition, Life Interrupted, Don McCullin uses black and white photography to tell us the astounding stories of the people he has visited. A world renowned photojournalist, McCullin travelled to South Africa … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Hazards of Solid Waste Management: Bioethical Problems, Principles, and Priorities
Authors: Margaret N. Maxey
Journal: Environmental Health Perspectives (1978)

The putative hazards of solid waste management cannot be evaluated without placing the problem within a cultural climate of crisis where some persons consider such by-products of “high, hard technology” to have raised unresolved moral and ethical issues. In order to assist scientific and technical efforts to protect public health and safety, a bioethical perspective requires us to examine three controversial aspects of policy-making about public safety. Failure to recognize the qualitative difference between two cognitive activities—risk-measurements (objective, scientific probabilities) and safety-judgments (subjective, shifting value priorities)—has had three unfortunate consequences. Sophisticated methods of risk analysis have been applied in a piecemeal, haphazard, ad hoc fashion within traditional institutions with the false expectation that incremental risk-reducing programs automatically ensure public health and safety. Ethical priorities require, first and foremost, a whole new field of data arranged for comparable risk-analyses. Critics of cost/risk/benefit quantifications attack the absurdity of “putting a price on human life” but have not been confronted with its threefold ethical justification. The widening discrepancy in risk-perceptions and loss of mutual confidence between scientific experts and ordinary citizens has placed a burden of social responsibility on members of the scientific and technical community to engage in more effective public education through the political process, notwithstanding advocates of a nonscientific adversary process. The urgency of effective public education has been demonstrated by the extent to which we have lost our historically balanced judgment about the alleged environmental hazards posed by advanced technology.
Early diagnosis, genetic marker sought for tuberous sclerosis
Authors: K. Simmons
Journal: JAMA (1984)

To some clinicians, tuberous sclerosis is as obscure as the textbook chapter from which they first learned of it. But to many others, tuberous sclerosis is becoming increasingly visible as advances are made by investigators studying its cause, diagnosis, prevention, and—it is hoped—eventual cure. Part of the interest stems from a growing realization that tuberous sclerosis probably afflicts more than the currently estimated one in 10,000 persons. There is also hope that techniques used to successfully identify a DNA "marker" for Huntington's disease using recombinant DNA technology (<i>Nature</i>1983; 306:234-238,<i>Arch Intern Med</i>[PRIMARY CARE MEDICINE] 1984;144:243-247) may be applied to tuberous sclerosis and may in the future provide means for prenatal diagnosis of the disorder. Experts from around the world met recently at the "Tuberous Sclerosis Research Workshop" to discuss future directions and research goals. The workshop, hosted by the Harvard-Massachusetts Institute of Technology Division of Health Sciences and
Can the NHS cut costs without substantially damaging the quality of health care? No
Authors: J. Appleby
Journal: BMJ (2010)

Rebecca Rosen (doi: 10.1136/bmj.c1967) and Paul Corrigan (doi: 10.1136/bmj.c1999) think that the NHS cost cutting that will occur over the next few years does not inevitably mean that the quality of care it provides will suffer. John Appleby and James Owen Drife (doi: 10.1136/bmj.c1966) are not so sure
Abdominal trauma
Authors: M. H. Worth
Journal: JAMA (1976)

THE INCREASING frequency in urban areas of penetrating abdominal wounds and in suburban and rural areas of blunt abdominal injuries makes trauma one of the leading causes of the acute abdomen in current surgical practice. Trauma represents an accelerated form of general surgery, and the usual criteria of peritoneal irritation and visceral damage should constitute the indications for celiotomy. <h3>To Operate or Not?</h3> Until the end of World War II, suspicion of peritoneal penetration was considered an adequate indication for abdominal exploration. The high incidence of normal findings in these circumstances suggested that approximately one third of patients could avoid operation by selective evaluation of individual cases. Although selective celiotomy requires a larger staff for observation, greater clinical acumen than routine exploration, and modification for local circumstances, the principle is valid. Peritoneal penetration under more controlled circumstances (ie, paracentesis, peritoneal dialysis, closed liver biopsy) is considered routine and safe on
Neurology: An Annotated Bibliography of Recent Literature
Journal: Annals of Internal Medicine (1979)

This bibliography includes references to 97 recently published journal papers and similar sources that represent important developments in the concept and practice of internal medicine. It has been compiled by the Neurology Committee as a part of the Medical Knowledge Self-Assessment Program V Syllabus. In preparing this bibliography, the committee reviewed MEDLINE† bibliographic printouts of journal articles published since the beginning of 1975 and also drew on sources in libraries of hospitals and other clinical institutions in the United States and Canada; thus only papers in English are listed, and most are from American journals.