tbuckley/cabot-search huggingface dataset:
Spectrum of human T-cell lymphotropic virus type III infection in children. Recognition of symptomatic, asymptomatic, and seronegative patients
Authors: S. Pahwa
Journal: JAMA (1986)

This study was done to gain insight into the clinical spectrum and immunologic disturbances resulting from infection with the human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) in children. Serum antibody to p41 antigen of HTLV-III and/or direct evidence of HTLV-III in lymphocytes was considered indicative of HTLV-III/LAV infection. In 36 children with HTLV-III/LAV infection, a wide clinical spectrum was noted, ranging from asymptomatic (seven children) to symptomatic, the latter including 14 children with the acquired immunodeficiency syndrome. Microcephaly was noted in five symptomatic infants. Immunologic dysfunction was noted in all symptomatic and in two asymptomatic children. Panhypogammaglobulinemia was noted in one child. Two asymptomatic children who were HTLV-III antibody negative had virologic evidence of HTLV-III infection. All of 20 mothers who were studied were HTLV-III antibody positive and had immunologic abnormalities but only nine were symptomatic, indicating that apparently healthy women may transmit HTLV-III/LAV infection to their offspring. (<i>JAMA</i>1986;255:2299-2305)
Hunterian Lectures ON MAN'S POSTURE: ITS EVOLUTION AND DISORDERS: Given at the Royal College of Surgeons of England
Authors: A. Keith
Journal: BMJ (1923)

METDIL JOUBRNAL 669 physical symptoms of chronic abdominalism, and presnmably the mental symptoms also, to " auto-intoxication."This doctrine lhas been so much discussed in recent years that I do not propose to weary you with a furtlher consideration of it; but altlhough there may be an element of self-poisoning in some of these cases, I feel bound to express the opinion that it will not account for all the symptoms.Nor have I any new theory to offer.There remains, when all is said, ani done, a good deal of mystery about the chronic abdomen, and it needs further study-especially, perhaps, from the psychological' side and from the standpoint of the relation of the vegetative nervous system to the emotions.
BOOK REVIEWS
Authors: J. D. HAINSWORTH
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Cancer Treatment, 3rd Edition Charles M. Haskell ed. Philadelphia: W. B. Saunders 1990 . XV, 1119 pp. $145.00. JOHN D. HAINSWORTH JOHN D. HAINSWORTH Division of Medical Oncology 1956 Vanderbilt Clinic Vanderbilt University Medical CenterNashville, TN 37232 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 23, 4 December 1991, Page 1757, https://doi.org/10.1093/jnci/83.23.1757 Published: 04 December 1991
THE INDIVIDUAL AND PHYLOGENIC GOOD OF PLAY.
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma Lipoproteins and Coronary Artery Disease.
Authors: M AVIRAM
Journal: Cardiovascular Research (1993)

Plasma Lipoproteins and Coronary Artery Disease. Get access M AVIRAM M AVIRAM Haifa, Israel Edited by R A Krasbery and J F Segrest. (Pp 390; £49.50.) Oxford: Blackwell, 1992. ISBN 0-86542-206-0. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 11, November 1993, Page 2085, https://doi.org/10.1093/cvr/27.11.2085 Published: 01 November 1993
What should the profession do about the incompetent physician?
Authors: R. C. Derbyshire
Journal: JAMA (1965)

Ideally answer to the question, "What should the profession do about the incompetent physician?" is too simple to warrant discussion. It should be answered with one word, prevention. There should not be any incompetent physicians, for their very existence could be prevented by several methods. First, selection of medical students should be on such a scientific basis that the potentially incompetent physician could be eliminated by denying him admission. If, despite the refinements of the inexact science of modern psychology an incompetent student is admitted he can be promptly eliminated at the end of the first year and certainly before graduation. What? Have we detected an incompetent house officer? Improbable, but it may not be too late to persuade him to adopt another profession because he surely will be denied a license by a state board of medical examiners. And here my story should end. But wait! Let's be practical.
Abstract 3021: The role of survivin splice variants in pancreatic ductal adenocarcinoma Gemcitabine resistance
Authors: Janviere Kabagwira, Amber Gonda, Mei Li Kwong
Journal: Cancer Research (2019)

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is a highly lethal disease with poor prognosis and an increased chemoresistance. Dysfunction in alternative splicing has been associated with chemoresistance in many cancers. Alternative splicing of survivin mRNA generates six splicing isoforms some of which are associated with cancer progression and chemoresistance. Survivin is a member of the inhibitors of apoptosis (IAPs) family and a cell cycle-associated oncoprotein overexpressed in almost all cancers. Interestingly, some of these survivin splice variants are proapoptotic (2α and 2β) while others are antiapoptotic (survivin, Δex3, 3α and 3β). It has been reported that increased levels of survivin 2β and 3β play a role in chemoresistance in ovarian cancers and other tumors, but this has not been studied in pancreatic cancer. Our recent RT-qPCR data also show an overexpression of all survivin splice variants in chemoresistant PDAC cell lines compared to the chemo-sensitive cell line. We, therefore, hypothesize that increased expression of survivin splice variants 2β and 3β contribute to chemo-resistance in PDAC. To test this hypothesis, we repeatedly selected the resistant cells from the normally chemosensitive MiaPaca2 cell line after exposure to gemcitabine. We then assessed the levels of survivin splice variants in the new cell line (gemcitabine-resistant MiaPaca2). Using the Alamar blue assay, we confirmed that Panc1 and gemcitabine-resistant MiaPaca2 are more resistant to gemcitabine compared to MiaPaca2 cells. We also observed a statistically significant overexpression of survivin 2β and 3β in gemcitabine-resistant cell lines compared to the more sensitive MiaPaca2 cells. To further test our hypothesis, we will knockdown survivin 2β and 3β in Panc1 and gemcitabine-resistant MiaPaca2, and/or overexpress these splice variants in MiaPaca2 cells then assess response to gemcitabine. The outcomes of this study might create new biomarkers for predicting the clinical outcomes of gemcitabine treatment and generate new therapeutic targets for pancreatic cancer. Note: This abstract was not presented at the meeting. Citation Format: Janviere Kabagwira, Amber Gonda, Mei Li Kwong. The role of survivin splice variants in pancreatic ductal adenocarcinoma Gemcitabine resistance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3021.
Bladder Decompensation Correlates With Diabetic Neuropathy
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholesterol and Violence: Is There A Connection?
Authors: Beatrice A. Golomb
Journal: Annals of Internal Medicine (1998)

Letters15 October 1998Cholesterol and Violence: Is There A Connection?Beatrice A. Golomb, MD, PhDBeatrice A. Golomb, MD, PhDUniversity of California, San Diego; San Diego Veterans Affairs Medical Center; La Jolla, CA 92161Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-8-199810150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Nash regrets that I have “inexplicably ignored the greater tragedy” that the National Cholesterol Education Panel's guidelines are not scrupulously followed. I agree there exist undertreated groups (for example, compliant middle-aged men who are at high risk for cardiovascular disease and have no history of psychiatric disease or alcohol abuse receive overall mortality benefit with statins and should definitely be treated), but this is irrelevant to the issue of whether other selected populations may receive no mortality benefit or accessory risk for violence. Dr. Nash charges that the meta-analyses were not prospective trials; however, meta-analyses never are. ...References1. Hibbeln J, Umhau J, George D, Salem N. Do plasma polyunsaturates predict hostility and depression? Metabolic and Behavioral Aspects in Health and Disease. 1997; 82:175-86. Google Scholar2. Anderson I, Parry-Billings M, Newsholme E. Dieting reduces plasma tryptophan and alters brain 5-HT function in women. Psychol Med. 1990; 20:785-91. Google Scholar3. Steegmans P, Fekkes D, Hoes A, Bak A, van der Does E, Grobbee D. Low serum cholesterol concentration and serotonin metabolism in men. BMJ. 1996; 312:221. Google Scholar4. Muldoon M, Kaplan J, Manuck S, Mann J. Effects of a low-fat diet on brain serotonergic responsivity in cynomolgus monkeys. Biol Psychiatry. 1992; 31:739-42. Google Scholar5. Kaplan J, Shively C, Fontenot D, Morgan TM, Howell SM, Manuck SB, et al. Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Psychosom Med. 1994; 56:479-84. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, San Diego; San Diego Veterans Affairs Medical Center; La Jolla, CA 92161 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReferences 15 October 1998Volume 129, Issue 8Page: 669-670KeywordsAlcoholismCholesterolDietDrugsFatty acidsMortalityQuestionnairesSerotoninStatinsWeight loss Issue Published: 15 October 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Blood sugar levels, glycosuria, and body weight related to development of diabetes mellitus. The Oxford epidemiologic study 17 years later
Authors: J. B. O'Sullivan
Journal: JAMA (1965)

Initial blood sugar levels were related to diabetes mellitus in a 17 year follow-up of the pioneer study in Oxford, Mass. Clinical diabetes was found 5 and 15 times more frequently for initial postprandial blood sugars (Folin-Wu) of 140 to 169 mg and 170 mg/100 ml and higher, respectively, than for those below 140 mg/100 ml. Glycosuria was important only when the blood sugar was above 170 mg/100 ml. A confirmatory repeat blood sugar level ≥140 mg/100 ml proved valuable in defining a high risk group for diabetes. The risk of diabetes in overweight persons was significant only when the blood sugar was above 140 mg/100 ml. The similar weight experience of the participants, regardless of their initial blood sugar level, makes it unlikely for obesity to be causally related to diabetes mellitus. The apparently contradictory results from postprandial and postglucose blood sugars are discussed.
Some Observations on the in Vitro Cytotoxicity of Chrysotile Prepared by the Wet Dispersion Process
Authors: I. P. Gormley, R. E. Bolton, G. M. Brown, J. M. G. Davis, A. Wright
Journal: Environmental Health Perspectives (1983)

Samples of the chrysotile taken during and after treatment by the wet dispersion process have been tested for their cytotoxic effect in vitro and the results compared with both a UICC chrysotile A sample and a dust prepared from a standard chrysotile textile yarn. Results were obtained from three different in vitro assay systems utilizing P388D1, V79-4 and A549 cells. A sample which still contained the wetting agent used in the wet dispersion process failed to show activity in any of these assays. The other samples, however, were all active with those dusts obtained by milling the final product and by sampling the air of the factory consistently proving significantly more cytotoxic than the standard chrysotile controls. Preliminary results from a parallel in vivo study suggest that these samples are also more active in producing mesotheliomas in rats.
Long-Term Symptoms after Spontaneous Clots in Upper Arm Veins
Journal: Annals of Internal Medicine (1999)

Summaries for Patients5 October 1999Long-Term Symptoms after Spontaneous Clots in Upper Arm VeinsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-7-199910050-00045 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Spontaneous axillary–subclavian venous thrombosis is a condition where blood clots develop in the veins of the upper arm area without an obvious reason such as injury to the arm. Some people with this condition develop long-term pain and swelling of the arm. It is unclear whether treating the condition with medication to dissolve the clot (thrombolysis) decreases the chances of long-term symptoms compared to treatment only with medicine that makes the blood take longer to clot (anticoagulants). It is also unclear how many people with axillary–subclavian thrombosis actually ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Long-Term Sequelae of Spontaneous axillary–subclavian Venous Thrombosis.” It is in the 5 October 1999 issue of Annals of Internal Medicine (volume 131, pages 510-513). The authors are E. Héron, O. Lozinguez, J. Emmerich, C. Laurian, and J.-N. Fiessinger.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Sequelae of Spontaneous Axillary–Subclavian Venous Thrombosis Emmanuel Héron , Olivier Lozinguez , Joseph Emmerich , Claude Laurian , and Jean-Noël Fiessinger Metrics 5 October 1999Volume 131, Issue 7Page: 510KeywordsAnticoagulantsDisabilitiesInflammationSportsThrombosisUltrasound imagingVeins ePublished: 15 August 2000 Issue Published: 5 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
"IMPEACHING" A HEALTH COMMISSIONER.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cell Specificity in DNA Binding and Repair of Chemical Carcinogens
Authors: James A. Swenberg, Douglas E. Rickert, Bonnie L. Baranyi, Jay I. Goodman
Journal: Environmental Health Perspectives (1983)

Many animal models for organ specific neoplasia have been developed and used to study the pathogenesis of cancer. Morphologic studies have usually concentrated on the response of target cells, whereas biochemical investigations have usually employed whole organ homogenates. Since hepatocytes comprise nearly 90% of the liver's mass and 70-80% of its DNA, alterations in DNA replication, covalent binding and DNA repair of nonparenchymal cells are usually obscured when whole organ homogenates are used. By utilizing cell separation methods, we have been able to demonstrate differences between hepatocyte and nonparenchymal cell replication. DNA damage and repair following exposure to a variety of hepatocarcinogen. Differences in removal of simple O6-alkylguanine and DNA replication correlate with cell specific carcinogenesis of simply alkylating agents. For several other procarcinogens, including 2-acetylaminofluorene and dinitroluene, cell specificity appears to reside primarily in the differential metabolic competence of hepatocytes and nonparenchymal cells. This results in greater covalent binding of the carcinogen to hepatocyte DNA, although the DNA adducts are removed at a similar rate in both cell types.
Morning Rounds
Authors: Sarath Reddy
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibiotics for respiratory illness.
Journal: BMJ (1976)

suggested by Mr Pearson and Miss Weaver, record many fewer movements per unit time than when they record for shorter periods.Presumably this is an effect of fatigue and reduced alertness.Recording during meals, conversation, reading, listening to music, etc, is not reliable.We instruct the women to assess and record each fetal movement for periods of 30-60 min three times a day.If the number of movements is less than three per hour the recording is continued for 6-12 hours in the day.From the sum of the movements recorded the rate per 12 hours-daily fetal movement recording (DFMR)-is calculated.Employing this method for a total of 1 5-3 hours a day the computed DFMR in 114 women with a normal outcome varied between 4 and 1440 per 12 hours.The majority of DFMRs were between 200 and 600 per 12 hours.In addition, the number of fetal movements recorded by an electromagnetic device' varied between 25 and 235 per hour.The patients recorded 87'. of
Mutagens in Coffee and Other Beverages
Authors: Minako Nagao, Yuki Fujita, Keiji Wakabayashi, Haruo Nukaya, Takuo Kosuge, Takashi Sugimura
Journal: Environmental Health Perspectives (1986)

A cup of coffee contains mutagens which produce about 5 X 10(4)-10(5) revertants of Salmonella typhimurium TA 100 without S9 mix. One of the mutagens was identified to be methylglyoxal. Methylglyoxal was present in various beverages such as black tea, whisky, and brandy. Methylglyoxal itself induced tumors in rats when administered by subcutaneous injection. However, the mutagenic properties of coffee were different from those of methylglyoxal. The mutagenicity of coffee was suppressed by catalase, and coffee was found to contain hydrogen peroxide. Furthermore, coffee solution was found to have a hydrogen peroxide-generating system. Instant coffee (15 mg/mL) contains 130 microM hydrogen peroxide immediately after the dissolution of coffee powder in water at room temperature. The concentration of hydrogen peroxide increased with time. The mutagenicity of methylglyoxal was increased by the copresence of hydrogen peroxide. A maximum of 30-fold enhancement was observed. The mutagenicity of black tea but not that of whisky was suppressed by catalase.