tbuckley/cabot-search huggingface dataset:
Rufus of Ephesus
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRI0014 Generation and characterization of monoclonal antibodies from single RA synovial B cells
Authors: V. Malmström, K. Amara, E. Meffre, L. Klareskog, H. Wardemann, J. Steen, F. Murray
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Anti-citrulline protein antibodies (ACPA) are a hallmark of HLA-associated RA, but it is still not established whether these antibodies represent a cause or a consequence of arthritis. It is however clear that such antibodies can enhance murine arthritis, but a corresponding effect in patients is difficult to prove. <h3>Objectives</h3> We have approached this question by assessing the specificity and immunoglobulin gene characteristics of B cells derived from RA synovial fluid of RA. <h3>Methods</h3> We have utilized a method that allows in vitro production of monoclonal antibodies derived from single human memory B cells. To this end we have cloned single flow cytometry purified CD19+IgG+ B cells from synovial fluid of four ACPA+ and three ACPA- RA patients and analyzed the seqences for mutational patterns. Moreover, we have expressed recombinant monoclonal antibodies from three of the ACPA+ and one ACPA- RA patient and tested, by ELISA, the generated antibodies for reactivity to different known citrullinated antigens. <h3>Results</h3> On the molecular level, striking differences were found between ACPA+ and ACPA- patients taking into consideration the mutational pattern of the Ig genes. Indeed, based on DNA sequences, we could demonstrate that B cells from ACPA+ patients did not have more total mutations than ACPA- patients but when focusing on the CDR1, 2 and 3 regions of the Ig variable region, the ACPA+ clones clones displayed strikingly more replacement mutations than did the ACPA- clones. Regarding the specificity of the generated monoclonal antibodies, our results so far show citrulline reactive antibodies could be found from the ACPA+ but not from the ACPA- RA patient. These recombinant antibodies demonstrated reactivity, to variable degrees, to CCP and different citrullinated antigens including citrullinated a-enolase, fibrinogen, and vimentin. <h3>Conclusions</h3> In summary, our data suggest that citrulline-reactive B cells are common in synovial fluid and the Ig molecules bear clear signs of antigen-driven maturation. <h3>Disclosure of Interest</h3> None Declared
Leukemia with Osteoarticular Symptoms and Signs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMERICAN MEDICAL STUDENTS ABROAD
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Addendum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment
Authors: Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota, Ryoji Kawakami, Keiko Yasuda, Daisuke Motooka, Shota Nakamura, Motonari Kondo, Ichiro Taniuchi, Terumi Kohwi-Shigematsu, Shimon Sakaguchi
Journal: Nature Immunology (2017)
Electric Ionization. A Practical Introduction to Its Use in Medicine and Surgery.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HbF production in β thalassaemia heterozygotes for the IVS‐II‐1 G→A β0‐globin mutation. Implication of the haplotype and the Gγ‐158 C→T mutation on the HbF level
Authors: George V.Z. Dedoussis, Georgia D. Mandilara, Marina Boussiu, Aphrodite Loutradis
Journal: American Journal of Hematology (2000)

We studied the presence of the XmnI site and the β-globin haplotype in 24 individuals, carriers of the IVSII-1 G→A β0-globin mutation, of whom fourteen had no detectable levels of HbF, while ten coming from 5 families, presented HbF levels ranging from 1.7 to 9% of the total Hb. Of these β-thalassaemia heterozygotes with fetal hemoglobin, 6 were females and 4 were males with median HbF levels of 4.85% and 4% respectively, and an excess of Gγ chains (range Gγ/Aγ: 55/45–70/30). Of the group of carriers of β-thalassaemia with HbF < 0.1, in all cases except one, IVSII-1 mutation was found associated with XmnI polymorphic site. Haplotype analysis in these individuals revealed that in 10 cases IVSII-1 was linked with haplotype IIIb, in 1 case with haplotype IIIa, and in 3 cases with haplotype IX. On the other hand, in the group of carriers with measurable levels of HbF, IVSII-1 was always associated with haplotype IIIa and the XmnI site was either in-homozygous or the heterozygous state in-cis or in-trans with the mutated β-globin gene. In conclusion the results of the study of these families seem that XmnI site in-cis with the IVSII-1 does not induce HbF production when this β0-thalassaemia mutation is associated with IIIb or IX haplotype. On the other hand the Gγ −158 C→T mutation is associated with small amounts of HbF in IVSII-1 heterozygotes, when the β-globin mutation is linked to haplotype IIIa. Am. J. Hematol. 64:151–155, 2000. © 2000 Wiley-Liss, Inc.
<i>QuickStats:</i> Percentage* of Children and Teens Aged 6–17 Years Who Missed &gt;10 Days of School in the Past 12 Months Because of Illness or Injury,<sup>†</sup> by Serious Emotional or Behavioral Difficulties Status<sup>§</sup> and Age Group — National Health Interview Survey, 2014–2016<sup>¶</sup>
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

During 2014-2016, children aged 6-17 years whose parent or guardian indicated the child had serious emotional or behavioral difficulties (EBDs) were almost four times as likely to miss >10 days of school because of illness or injury compared with children without serious EBDs (13.4% compared with 3.5%). Among children with serious EBDs, those aged 6-10 years were less likely (8.0%) to miss >10 days of school compared with children aged 11-14 years (15.6%) and children aged 15-17 years (19.5%). Among children without serious EBDs those aged 15-17 years (4.7%) were more likely to miss >10 school days compared with children aged 6-10 years (3.0%) and children aged 11-14 years (3.3%).
"Superfluous Spectacles."
Authors: James Moores Ball
Journal: JAMA (1894)

Keokuk, Iowa, Feb. 24, 1891. <h3>To the Editor:</h3> —Superfluous spectacles are those prescribed by incompetent persons. Who are they? Surely not the educated physician who, after years of preparation, drops into ophthalmology by a sort of natural affinity; surely not the man or woman, who, when examining the eye, sees not only an optical apparatus but a living being behind it. No. The incompetents are those half-hatched and abortive products ground out by the so-called "ophthalmic colleges." These "colleges" are engaged in manufacturing opticians out of jewelers and oculists out of jays. Six weeks' time suffices in either case to produce a diploma-bearing individual who goes forth to prey upon the credulity of the populace. These are the persons who are to blame for "superfluous spectacles." Every educated physician engaged in ophthalmic practice, knows that many cases of asthenopia in which refractive error exists, are not cured by glasses. The
DDEL-11. CONVECTION-ENHANCED DELIVERY OF EZH2 INHIBITOR FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA
Authors: Takahiro Sasaki, Hiroaki Katagi, Stewart Goldman, Oren Becher, Rintaro Hashizume
Journal: Neuro-Oncology (2020)

Abstract BACKGROUND Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brain tumor and the majority of patients die within 2 years after initial diagnosis. Factors that contribute to the dismal prognosis of these patients include the infiltrative nature and anatomic location in an eloquent area of the brain, which precludes total surgical resection, and the presence of the blood-brain barrier (BBB), which reduces the distribution of systemically administered agents. Convection-enhanced delivery (CED) is a direct infusion technique to deliver therapeutic agents into a target site in the brain and able to deliver a high concentration drug to the infusion site without systemic toxicities. OBJECTIVE This study aims to assess the efficacy of enhancer of zeste homolog-2 (EZH2) inhibitor by CED against human DIPG xenograft models. METHODS The concentration of EZH2 inhibitor (EPZ-6438) in the brainstem tumor was evaluated by liquid chromatography–mass spectrometry (LC/MS). We treated mice bearing human DIPG xenografts with EPZ-6438 using systemic (intraperitoneal) or CED administration. Intracranial tumor growth was monitored by bioluminescence image and the therapeutic response was evaluated by animal survival. RESULTS LC/MS analysis showed that the concentration of EPZ-6438 in the brainstem tumor was 3.74% of serum concentration after systemic administration. CED of EPZ-6438 suppressed tumor growth and significantly extended animal survival when compared to systemic administration of EPZ-6438 (P=0.0475). CONCLUSION Our results indicate that CED of an EZH2 inhibitor is a promising strategy to bypass the BBB and to increase the efficacy of an EZH2 inhibitor for the treatment of DIPG.
Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Authors: F. Cardoso, S. Kyriakides, S. Ohno, F. Penault-Llorca, P. Poortmans, I.T. Rubio, S. Zackrisson, E. Senkus
Journal: Annals of Oncology (2019)

Ann Oncol 2019; 00: 128 (doi:10.1093/annonc/mdz173) Supplementary material was erroneously uploaded for this paper but the file was not intended for publication. This has now been removed. Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upAnnals of OncologyVol. 30Issue 8PreviewIn 2018, the predicted number of new breast cancers in 28 European Union (EU) countries was 404 920, with estimated age-adjusted annual incidence of breast cancer of 144.9/100 000 and mortality of 32.9/100 000, with 98 755 predicted deaths [1]. Worldwide, there was about 2.1 million newly diagnosed female breast cancer cases in 2018, accounting for almost one in four cancer cases among women, and ∼630 000 died of it [2]. Breast cancer incidence has increased since the introduction of mammography screening and continues to grow with the ageing of the population. Full-Text PDF Open Archive
Long-term follow-up of a phase I/II trial of radioimmunotherapy (RIT) with yttrium 90 (<sup>90</sup>Y) ibritumomab tiuxetan for CD20+ B-cell non-Hodgkin's lymphoma (NHL)
Authors: L. I. Gordon, A. Molina, C. Emmanouilides, A. Raubitschek, M. Darif, R. J. Schilder, G. A. Wiseman, C. A. White, T. E. Witzig
Journal: Journal of Clinical Oncology (2004)

6574
Rates of cutaneous reactions to drugs. A report from the Boston Collaborative Drug Surveillance Program
Authors: K. A. Arndt
Journal: JAMA (1976)

Rates of allergic skin reactions to commonly used drugs were estimated from data obtained on 22,227 consecutively monitored medical inpatients. A total of 57 drugs were implicated in skin reactions. Five or more reactions were attributed to each of 22 drugs (or drug groups). Many commonly used drugs did not appear to cause any allergic reactions. The study provides the practicing physician with drug-specific quantitative data that can be used to evaluate the causes of drug-induced rash, itching, or hives. (<i>JAMA</i>235:918-922, 1976)
Council on Physical Therapy
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
History of the Massachusetts General Hospital, June, 1872, to December, 1900.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NATURAL HISTORY OF A NEWLY RECOGNIZED RESPIRATORY VIRUS (RESPIRATORY SYNCYTIAL)
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Report from the PHLS Communicable Disease Surveillance Centre.
Journal: BMJ (1987)

protein particles out of the nucleus, including ribosomes and messenger RNA.This process is also highly selective, resulting in the export of mature transcripts but the retention in the nucleus of immatuce transcripts.The basis of this selectivity is unknown, but in at least one case there is evidence of a carrier mediated transport system. Rebuilding the ceil nucleusRecently there have been substantial advances in our ability to reconstruct "nuclei" from condensed chromatin or even purified DNA in cell free systems.Figure 3 shows a large fully enveloped nucleus which has been formed from demembranated frog sperm chromatin in a cell free system derived from frog eggs.Similar structures have now been formed from purified DNA, including DNA from bacterial viruses and plasmids.Not only is such DNA assembled into chromatin; it also becomes surrounded by nuclear membranes containing functional nuclear pores.Thus these pseudo- nuclei fill up with nuclear proteins and even replicate their DNA in vitro.The opportunity to reconstruct functioning nuclei and function- ing chromosomes opens up new approaches to understanding the complex structure and function of the cell nucleus.
History of Public Health
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WEIR MITCHELL ON GEORGE WASHINGTON.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal