tbuckley/cabot-search huggingface dataset:
Early Mesopotamian Medicine
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infections of the urinary tract. Fundamental concepts of diagnosis and treatment
Authors: E. N. Cook
Journal: JAMA (1966)

During recent years, the doctrines propounded by many physicians, even in the field of internal medicine, have brought about an explosion of major significance concerning cause, diagnosis, and management of infections of the urinary tract. These physicians have outlined a number of tedious programs and complicated laboratory procedures which are most impractical for the average physician and for the urologist as well. Actually, these theoretical suggestions have offered little that is new or of value. For decades, most urologists have been aware of the importance of asepsis in obtaining specimens of urine for study and evaluation. The so-called explosion of the past decade concerning the use of the catheter is of value in that it has awakened the medical profession generally to these facts concerning the need for the strictest care in collecting and studying urinary sediment. Even if we grant that this contribution was worthwhile, it, unfortunately, was not
Corrosive gastritis resembling carcinoma, due to ingestion of acid
Authors: R. T. Holzbach
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Oral ingestion of corrosive substances has become an infrequent event. Most physicians remain familiar with the effects of lye ingestion resulting in esophageal stricture. Chronic effects resulting from other corrosives are encountered. In an experience in which the nature of the ingested corrosive was not clearly established at first (mistakenly assumed to have been lye) the history of ingestion was dismissed as clinically irrelevant. <h3>Report of a Case:—</h3> A 69-year-old man was admitted to St. Luke's Hospital on Feb 9, 1968, because of epigastric pain. The patient was apparently well until Jan 8, when because of depression, he swallowed about one third to one half cupful of cleaning material assumed to be lye. Immediately afterward the patient felt severe burning pain in the substernal and upper abdominal areas. During three weeks in a hospital the patient continued to have epigastric pain, more pronounced after eating. Vomitus on
Father's Day
Authors: Albert J. Herrmann
Journal: JAMA (1990)

My father died of lung cancer in 1975. He was a physician. Much has been written about the marriages of physicians— the satisfactions, the discord, the dynamics of these marriages. What of the effect of the physician's life on his or her children? What will they remember of their physician/father? What legacy does his quality of life leave them? I doubt my father would ever have guessed my answer; less would he imagine the profound effect his life has had on mine. The wife chooses her husband; the child knows no choice. One's father is the norm against whom all other fathers are measured. Other children's fathers played ball with them, took them camping and on vacations. They taught their children fair play, an appreciation of nature, and the importance of family. Paradoxically, it was my father's absences that taught me something more, a stratum above: the meaning of responsibility,
Do low levels of iron affect body's ability to regulate temperature, experience cold?
Authors: T. F. Kirn
Journal: JAMA (1988)

IN PENNSYLVANIA, one researcher was placing women volunteers into cold baths and recording their temperatures. At about the same time, another researcher was flying women volunteers to North Dakota and seating them on a chaise longue in a cold room until they got goose bumps. Both researchers are nutritionists interested in iron nourishment. Both wanted to see if low levels of iron affect the body's ability to regulate temperature. Women are better subjects, these researchers say, because they are more likely to become iron deficient as a result of iron losses with menstruation. (Both researchers have been measuring levels of the iron-carrying protein ferritin in the blood.) Neither researcher was aware of the other's project until each was well into the work and by chance they encountered each other at a conference. <h3>Experiencing Cold</h3> The researchers have remarkably similar findings and each has come to a similar conclusion: iron-deficient women
Suppurative Flexor Tenosynovitis After Accidental Self-Inoculation With Streptococcus pneumoniae Type I
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Americal Surgical Association. Vol. VII.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS
Authors: Jone López-Erauskin, Takahiro Tadokoro, Michael W. Baughn, Brian Myers, Melissa McAlonis-Downes, Carlos Chillon-Marinas, Joshua N. Asiaban, Jonathan Artates, Anh T. Bui, Anne P. Vetto, Sandra K. Lee, Ai Vy Le, Ying Sun, Mélanie Jambeau, Jihane Boubaker, Deborah Swing, Jinsong Qiu, Geoffrey G. Hicks, Zhengyu Ouyang, Xiang-Dong Fu, Lino Tessarollo, Shuo-Chien Ling, Philippe A. Parone, Christopher E. Shaw, Martin Marsala, Clotilde Lagier-Tourenne, Don W. Cleveland, Sandrine Da Cruz
Journal: Neuron (2020)

(Neuron 100, 816–830.e1–e7; November 21, 2018) In the original publication of this paper, the concentration of the puromycin was incorrectly reported. In both panel A of Figure 7 and the “In vivo protein synthesis labeling” section of the STAR Methods, the amount was listed as 10 μg/kg. The correct concentration should be 10 mg/kg. The authors apologize for this error. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUSLópez-Erauskin et al.NeuronOctober 18, 2018In BriefMutations in FUS are causative of ALS and frontotemporal dementia (FTD). López-Erauskin et al. show that disease-causing mutant FUS inhibits intra-axonal protein synthesis and provokes hippocampal synaptic loss and dysfunction without loss of nuclear FUS function or FUS aggregation. Full-Text PDF Open Access
Randomized controlled trials (RCTs) examining continuous (CS) versus intermittent strategies (IS) of delivering systemic treatment (Tx) for untreated metastatic colorectal cancer (mCRC): An updated meta-analysis from the Cancer Care Ontario program in evidence-based care.
Authors: Scott R. Berry, Roxanne Cosby, Timothy R. Asmis, Kelvin K. Chan, Nazik Hammad, Monika K Krzyzanowska
Journal: Journal of Clinical Oncology (2014)

3567 Background: There is varied impact on efficacy demonstrated in individual RCTs of CS vs IS of delivering systemic Tx for mCRC. Our meta-analysis of the available RCTs was updated to include results of the CAIRO3 trial. Methods: RCTs that compared a CS versus IS of delivering systemic Tx were identified by a systematic search and review. The results of identified trials were clinically homogeneous (Table) so the data were pooled using Review Manager software (RevMan 5.2). Overall survival (OS) hazard ratios (HRs) were extracted from the most recently reported trial results. A random effects model was used for all pooling. Results: 11 RCTs were identified (n= 4,809). For the 8 trials with available OS HRs, the Tx patients received after induction was: none (5 trials, n=3,036), fluoropyrimidine (1 trial, n=620), biologic (2 trials, n=852). Results of the meta-analysis are summarized in the Table (HR>1 favors CS). Sensitivity analyses demonstrated results were generally robust across induction and maintenance regimens. One sensitivity analysis of the 3 trials (CAIRO3, OPTIMOX2, COIN, n=2,389) with combination Tx induction and no maintenance Tx until progression revealed a statistically, but non-clinically significant benefit for continuous treatment (HR=1.10, 95% CI 1.00-1.20, p=0.05). QOL (data from 3 trials) was either the same in both arms (2 trials with no maintenance Tx, n=911) or improved in the IS arm (1 trial with no maintenance Tx, n=1,630). Conclusions: IS of delivering systemic Tx for mCRC do not result in a clinically significant reduction in OS compared to a CS of delivery whether or not maintenance therapy is included. QOL is the same or better with an IS. OS HR (95% CI) Test for overall effect - Z Heterogeneity chi2 (df) I2 (%) All trials (n=4,508*) 1.03 (0.96 – 1.10) 0.89 (p=0.38) 6.01 (7) (p=0.54) 0 Trials with no maintenance Tx (n=3036*) 1.03 (0.94 – 1.14) 0.68 (p=0.50) 5.03 (4) (p=0.28) 20 Trials with maintenance Tx (n=1,472*) 1.00 (0.88 – 1.14) 0.01 (p=0.99) 0.69 (2) (p=0.71) 0 * n = number of patients in trials with available HRs.
Abstract 14783: Relationship Between Native Papillary Muscle T1 Time and Severity of Functional Mitral Regurgitation in Patients With Non-ischemic Dilated Cardiomyopathy
Authors: Shingo Kato, Sébastien Roujol, Francesca Delling, Shadi Akhtari, Jihye Jang, Tamer Basha, Sophie Berg, Kraig Kissinger, Beth Goddu, Warren Manning, Reza Nezafat
Journal: Circulation (2015)

Introduction: Functional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy (DCM). Non-contrast native T1 mapping has emerged as a non-invasive method to evaluate myocardial fibrosis. Hypothesis: We hypothesized that papillary muscle native T1 time is correlated with severity of functional mitral regurgitation in DCM patients. Methods: Forty DCM patients (55±13 years) and 20 healthy adult control subjects (54±13 years) were studied. Native T1 mapping was performed using a slice interleaved T1 mapping sequence (STONE) which enables acquisition of 5 slices in the short-axis plane within a 90 sec free-breathing scan. We measured papillary muscle diameter, length and shortening. DCM patients were allocated into 2 groups based on the presence or absence of functional mitral regurgitation. Results: Papillary muscle T1 time was significantly elevated in DCM patients with mitral regurgitation (n=22) in comparison to those without mitral regurgitation (n=18) (anterior papillary muscle: 1127±36 msec vs 1063±16 msec, p&lt;0.001; posterior papillary muscle: 1124±30 msec vs 1062±19 msec, p&lt;0.001), but LV T1 time was similar (1129±38 msec vs 1134±58 msec, p=0.93). Multivariate linear regression analysis showed that papillary muscle native T1 time (β=0.109, 95%CI: 0.048-0.170, p=0.001) and tenting height (β=1.334, 95%CI: 0.434-2.234, p=0.005) are significantly correlated with mitral regurgitant fraction. Elevated papillary muscle T1 time was associated with larger diameter, longer length and decreased papillary muscle shortening (all p values &lt;0.05). Conclusions: In DCM, papillary muscle native T1 time is significantly elevated and related to mitral regurgitant fraction. These results suggest that papillary muscle diffuse fibrosis might be associated with severity of mitral regurgitation in this population.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1964)

TuberculosisA thirty-one-year-old gravida 2, para 2, died of pulmonary tuberculosis fourteen days post partum. Both children survived in good health, with persistently negative tuberculin tests.Pulmonary disease began as pneumonia when the patient was four weeks old and recurred twice as pleurisy at the ages of fourteen and fifteen, when she also had rheumatic fever. The certain diagnosis of tuberculosis was made at seventeen years of age, when she first entered a sanatorium for two years, receiving treatment with pneumothorax and streptomycin. Skin tests and sputum remained positive. At the age of twenty-three, after a thoracoplasty and lucite plombage . . .
Errors in Data in Results Section of Abstract and Text
Authors: Abdulla Damluji, Gary Gerstenblith, Jodi Segal
Journal: JAMA Cardiology (2020)

Trisha Singh, BM; Rong Bing, MBBS; Marc R. Dweck, MD, PhD; Edwin J. R. van Beek, MD, PhD; Nicholas L. Mills, MD, PhD; Michelle C. Williams, MBChB, PhD; Todd C. Villines, MD; David E. Newby, MD, PhD; Philip D. Adamson, MBChB, PhD
Once-Daily Treatment with Beclomethasone Dipropionate Nasal Aerosol Is Effective in Improving Total Nasal Symptom Scores (TNSS) in Children with Perennial Allergic Rhinitis (PAR) Regardless of Baseline Symptom Severity
Authors: Niran J. Amar, William E. Berger, Robert L. Jacobs, Calvin Small
Journal: Journal of Allergy and Clinical Immunology (2015)
NATIONAL ORGANIZATIONS OF MEDICAL INTEREST
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The naturalness of dying
Authors: J. D. McCue
Journal: JAMA (1995)

Evidence that dying occurs as a natural, final event in the wholeness of human life is culturally, artistically, and scientifically persuasive. Very elderly patients eventually undergo a process of functional declines, progressive apathy, and loss of willingness to eat and drink that culminates in death, even in the absence of acute illness or severe chronic disease. Despite clinical resemblances to depression and dementia, aging itself and a loss of will to live are the most probable explanations for natural dying. Acceptance of the naturalness of dying, however, directly conflicts with the medicalization and legalization of death that characterizes modern society's treatment of dying elderly patients. We prefer instead to believe that dying results from disease and injury, which may yield to advances in medical technology. The progressive move of the dying out of the home and into acute and long-term care facilities suggests that medicalization may be an irreversible process. Viewing dying as an independent diagnosis in patients who are obviously undergoing terminal declines from aging and chronic diseases can facilitate communication about spiritual and palliative care needs, which tend to be neglected in the medicalized view of dying. Physicians and nurses may need to assume the role of medical stewardship to help prevent the overtreatment and overtesting of modern medicine's approach to the dying. The emotional burdens of caring for the dying elderly, however, must be addressed openly through collaborative work, institutional policies on limitation of treatment, and support building among physicians and other caregivers. (<i>JAMA</i>. 1995;273:1039-1043)
MUTUAL CONSULTATIONS ARE NOT CONFIDENTIAL.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bloodstained tears.
Authors: D. C. Siggers
Journal: BMJ (1970)

MBDICALIOURNAL 177 account of a painful hip owing to ischaemic necrosis complicating an old fracture of the femoral neck.During the operation of McKee-Farrar total hip replacement con- siderable osteoporosis was encountered, and insertion of the femoral component required twice the usual amount of cement.Immedi- ately following reduction of the hip, profound hypotension and bradycardia occurred.There were no warning signs on the E.C.G.Cardiac arrest ensued, and attempts at resuscitation were unsuccessful.Necropsy showed air and fat in the pelvic veins on the side of the operation, right heart, and in the coronary vessels.There was marked myocardial degeneration.The cause of death was considered to be air embolism acting on a previously defective myocardium.It would seem possible that air (or fat) embolism might account for some of the cases of transient hypotension with recov- ery.We now use a polythene tube while inserting the cement and note the consider- able quantities of fat and air which are expelled through it.We also feel that we should use an oesophageal stethoscope and a central venous pressure line (for diagnosis and treatment) as recommended recently by O'Higgins.'-We are, etc.,
Agnosis: Cambridge
Authors: Daniel Bosch
Journal: Annals of Internal Medicine (2011)

Ad Libitum15 February 2011Agnosis: CambridgeDaniel BoschDaniel BoschFrom Cambridge, MA 02139Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-4-201102150-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Truth is concise, ever to dragIt out, unthinkable; for here and nowHave given way to next, a placeWhere nothing's read; where voice and textArrive, and each is saved; where every dayIs holy, each bell lauds; where all thumbsDouble-cross keypads with a graceQuite unmistakable for faith; where God'sCell's set to “vibrate.” Ritual? And how:After a lecture, one by one,My students dip into a bagOr backpack, from which each retrievesA phone that she flips open as she leaves,So she may glance—still in conversation—To see some back-lit proof of love, or none.Daniel BoschCambridge, MA 02139 Author, Article, and Disclosure InformationAffiliations: From Cambridge, MA 02139Current Author Address: Daniel Bosch, 154 Auburn Street, 2w, Cambridge, MA 02139. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 2011Volume 154, Issue 4Page: 226 ePublished: 15 February 2011 Issue Published: 15 February 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The new federalism for health: shifting responsibilities and reducing costs into the 80s
Authors: R. N. Rubin
Journal: JAMA (1982)

The year 1982 has presented the President and the Congress with an opportunity to restructure the role of the federal government in its dealings with other levels of government and with its citizens. In health, a new era of federal-state relationships is possible, with all the old guidepost relationships established during the 1960s and 1970s becoming obsolete. In 1982, decisions on health programs and the structure of the federal involvement in these programs will be made based on a different set of imperatives than has been the case before. Unemployment is at near-record highs. Interest rates remain high, and both the President and the Congress are predicting record-breaking peacetime budget deficits for the coming years. The Congressional Budget Office has forecast that, under current law, the federal budget deficit will reach 5% of the gross national product (GNP) in 1984. The White House, while using more optimistic assumptions, still has