tbuckley/cabot-search huggingface dataset:
ACS-NIH organ transplant registry. Third scientific report
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rh and Other Blood Groups
Authors: Louis K. Diamond, Fred H. Allen
Journal: New England Journal of Medicine (1949)

THE Rh and other blood groups have achieved great importance in the last few years because of their relation to erythroblastosis fetalis. But numerically this disease may not emphasize the need for practical knowledge about blood groups as often as blood transfusion does — a therapeutic procedure that has become relatively simple and used, or sometimes possibly abused, probably several million times a year. In addition, genetic and anthropologic studies using blood-group characteristics have been revitalized by the discovery of the newer and now much more numerous blood agglutinogens. And finally, medicolegal problems, which formerly were unsolvable because of too . . .
Cerebral blood flow and metabolism in fulminant liver failure
Authors: J Wendon
Journal: Hepatology (1994)

Fulminant liver failure is a syndrome that is frequently complicated by cerebral edema and increased intracranial pressure. Cerebral blood flow has been reported as high in some studies but low in others. This study undertook to measure cerebral blood flow and cerebral metabolic rate for oxygen in 30 patients with fulminant liver failure in grade 4 encephalopathy and to assess these parameters after intervention with hyperventilation and infusions of mannitol, epoprostenol and acetylcysteine. Cerebral blood flow varied widely, from 14 to 71 ml/100 gm/min (normal range, 41 to 66), whereas the cerebral metabolic rate for oxygen was low in all patients, 0.16 to 2.03 ml/100 gm/min (normal range, 3.12 to 3.96). Twenty-one of the 30 patients had evidence of anaerobic metabolism with cerebral lactate production. Hyperventilation resulted in a significant decrease in both cerebral blood flow (median, 36 to 28 ml/100 gm/min) and cerebral metabolic rate for oxygen (median, 0.92 to 0.65 ml/100 gm/min); mannitol and acetylcysteine infusions resulted in significant increases in both of these parameters. Prostaglandin I2 infusion did not significantly alter cerebral blood flow, but there was a significant increase in cerebral metabolic rate for oxygen. The depressed cerebral metabolic rate for oxygen in patients with fulminant liver failure is inappropriate to metabolic requirements, as demonstrated by both cerebral lactate production and the increase in cerebral oxygen consumption after improvement in cerebral blood flow. Mannitol infusion should remain the main treatment of the cerebral complications of fulminant liver failure. Acetylcysteine has a beneficial effect that is not restricted to fulminant liver failure after acetaminophen overdose and has a role in the management of patients, regardless of cause of illness. The use of prostaglandin I2 appears to be safe and may be beneficial. Acute hyperventilation causes decreases in both cerebral blood flow and cerebral metabolic rate for oxygen and has the potential to worsen cerebral ischemia. (HEPATOLOGY 1994;19:1407–1413.)
A compendium of unpublished phase III clinical trials in oncology: Characteristics and impact on clinical practice.
Authors: V. C. Tam, I. Tannock, J. Rauw, M. K. Krzyzanowska
Journal: Journal of Clinical Oncology (2010)

6029 Background: Phase III clinical trials provide the highest level of evidence to inform treatment decisions. A large number of phase III clinical trials are presented at ASCO annual meetings each year but 26% remain unpublished within 5 years of presentation. The results of these unpublished trials, if more generally known, may have a substantial impact on clinical practice. Methods: We identified abstracts of phase III clinical trials with sample size ≥ 200 that evaluated systemic treatment for cancer by hand searching the conference proceedings of ASCO annual meetings between 1989 and 2003. PubMed, Medline and Embase were searched for corresponding publications. A compendium of unpublished phase III clinical trials was assembled. The clinical significance of nonpublication was determined by experts in each oncology site group at Princess Margaret Hospital and Sunnybrook Odette Cancer Centre, Toronto, Canada. Results: A total of 713 phase III trials were identified and our initial search suggested that 80 remained without a subsequent publication by 2009. After contacting the authors of the abstracts an additional 8 studies were found to be published and 3 were in press, leaving 69 abstracts without a subsequent publication. Unpublished trials included those for patients with breast cancer (n = 24), gastrointestinal cancer (n = 14), lung cancer (n = 9), hematologic malignancies (n = 9), gynecologic cancer (n = 6), genitourinary cancer (n = 4), central nervous system tumors (n = 2) and head and neck cancer (n = 1). 51% of these abstracts were presented orally and 29% as posters. 68% of the unpublished abstracts reported non-significant results. In the opinion of the experts, a number of unpublished trials would have had at least some effect on clinical practice if their results had been published promptly, including 10 of the 14 gastrointestinal cancer trials and 3 of the 9 lung cancer trials. Conclusions: A considerable proportion of large phase III trials remain unpublished at least 6 years following presentation at ASCO annual meetings. Nonpublication breaks the contract made by investigators with patients, funding agencies and ethics boards, and can adversely influence clinical practice. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca, Exelixis, Roche
Correction: Cardiac arrhythmias in thalassaemia major
Journal: BMJ (1978)

, being individual to the patient (but it should be reassessed every 1-3 months).The narrower equivalent range of 13-15 kPa -with a critical arithmetic mean of 14 kPa (105 mm Hg)-could, however, be used; only extensive statistical evaluation will determine the most clinically realistic range.
Postservice Mortality Among Vietnam Veterans
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Data
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A career in nuclear medicine
Authors: John Frank
Journal: BMJ (2004)

John Frank explains why nuclear medicine has become a major imaging specialty, crucial to both diagnosis and therapy, and offers a guide to becoming a part of it Nuclear medicine is the branch of imaging that uses radio-isotopes to study the physiology and metabolism of the body (rather than the anatomy shown by x rays, computed tomography (CT), ultrasound, and magnetic resonance imaging (MRI)). Nuclear medicine today is the exciting development of the early 20th century pioneering work of, among others, Rutherford, the Curies, and Lawrence, who built the first cyclotron in 1933. With all the new isotopes and radiopharmaceuticals we now have available, there is huge scope for advances in the field. If you are the sort of person who would enjoy the challenge of working in a rapidly developing multicraft specialty, then you may well be a candidate for a national training number (NTN) in nuclear medicine. It also helps to be computer literate. There have been many recent advances in nuclear medicine, but without doubt the most exciting is the development of positron emission tomography (PET) imaging, and in particular PET/CT. This has revolutionised oncological imaging, and ideally no major cancer centre should be without PET. Nuclear medicine, being essentially physiological, correlates well with all other forms of imaging, which are mainly anatomical. We can show the activity of disease rather than the anatomical appearance. For example, in Crohn's disease the barium enema will show what the bowel looks like, but the labelled white cell scan will show the extent of activity. It's a vital tool for the clinician. There is therefore a huge interaction with the rest of imaging, the clinicians and the oncologists. Box 1 shows a typical week in nuclear medicine. ### Box 1: A typical week in nuclear medicineRETURN TO TEXT
Effect of H + Ion Activity and Ca 2+ on the Toxicity of Metals in the Environment
Authors: T. C. Hutchinson, F. W. Collins
Journal: Environmental Health Perspectives (1978)

The role of acidity in determining and restricting plant distribution and performance is discussed.In soils especially, a key effect of HI ion concentration is on the solublity of potentially toxic heavy metals such as aluminum, manganese, zinc, iron, copper, and nickel.Al has been reported from many studies since the 1920's as the key determining toxic factor in acid soils.Some acid-tolerant species have been shown to be especially tolerant of Al, and mechanisms of tolerance have been suggested.Mn is also a commonly toxic factor at soil pH less than 5.0.Calcium has been shown to alleviate Mn toxicity.Low pH soils are also generally low in Ca, K, Na, and P; all essential major elements for plant growth.In lakes and marine situations acidic waters are uncommon as the waters are buffered.Calcium is again ameliorative of metal toxicities.The pH, redox, and valency state are critical in determining nutrient availability and metal speciation.Recent increases in the HI ion content of precipitation have caused increased acidities of freshwater lakes in Scandinavia and eastern North America, which have depleted biota, including fish populations.
Proceedings of the Nineteenth Annual Meeting of the Missouri Pharmaceutical Association, held at Meramec Highlands, June 8-12, 1897.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
William Harvey, a conventional medical revolutionary
Authors: J. J. Bylebyl
Journal: JAMA (1978)

IN 1637, Raffaello Magiotti, a priest and scientist, wrote from Rome to Florence to inform his friends, including the aged Galileo, of a physiological discovery about which he had recently learned. He concluded: This is the circulation which the blood traverses within us. It has been observed in our time, and will suffice to revolutionize all of medicine, just as the invention of the telescope has done for astronomy, the compass has done for commerce, and artillery has done for the whole military art. Two points are particularly striking: that Magiotti should expect the knowledge of the circulation to have such a profound impact on medicine, and that he should compare it to a series of concrete technological devices. In his view, the circulation is not some abstract theory, but a fact that one can observe almost as one can see a telescope, a compass, or a cannon. How did
Dying
Authors: John Graham-Pole
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE HOUSING PROBLEM.
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Politicians, AIDS experts wage budget debate
Authors: R. Voelker
Journal: JAMA (1996)

A NEW REPORT that recommends restructuring federal AIDS research has reignited a tug-of-war over who should control the purse strings for such research. During a news conference last month in Chicago, Ill, a trio of AIDS experts called on a small group in Congress to restore full spending authority to the Office of AIDS Research (OAR) of the National Institutes of Health (NIH). "The promise of AIDS research is very much at risk because of these debates," said Mathilde Krim, PhD, chair of the American Foundation for AIDS Research (AmFAR). Krim was joined by Mark Harrington, policy director of the New York, NY—based Treatment Action Group, and Steven Wolinsky, MD, associate professor of medicine at the Northwestern University Medical School in Chicago. Harrington and Wolinsky were among the 114 scientists, academics, drug company representatives, and community advocates who conducted a sweeping review of the $1.4 billion NIH AIDS research effort.
On Diseases of Joints
Authors: H. Coote
Journal: BMJ (1858)

Thushed fromi tihe violent struggles; the bowels were costive; the urine I could learn nothing about.The os uteri was moderately dilat 1, but high up; the membranes were entire, the head pr.'.-sentinig.I put a dose of calomel on her tongue, -ave her several doses of black draught and jalap, administered a stimlulatiig enerlia, anld, on the convulsions recurring, dashed oold water iti hler face.The treatment appeared to have some atthet.as ti' -; (lid not recur so frequently, neither were they so violent fi) '-2' or hours.At 5 r.Ir., however, she had a very severe, oia.Un her comling.out of it, I decided to apply Pie long foirl-s; and with some difficulty, in consequence of her restlesnr-ei delivered her of a living child.rather more than seven houirs; from her first convulsion.Flooding followed; and, us i'lie 'roubth did not contract, I introduced my hand, and hrou-ght awav 11' placeiita.There were no more convulsions,
An Evaluation of Climate/Mortality Relationships in Large U.S. Cities and the Possible Impacts of a Climate Change
Authors: Laurence S. Kalkstein, J. Scott Greene
Journal: Environmental Health Perspectives (1997)

A new air mass-based synoptic procedure is used to evaluate climate/mortality relationships as they presently exist and to estimate how a predicted global warming might alter these values. Forty-four large U.S. cities with metropolitan areas exceeding 1 million in population are analyzed. Sharp increases in mortality are noted in summer for most cities in the East and Midwest when two particular air masses are present. A very warm air mass of maritime origin is most important in the eastern United States, which when present can increase daily mortality by as many as 30 deaths in large cities. A hot, dry air mass is important in many cities, and, although rare in the East, can increase daily mortality by up to 50 deaths. Cities in the South and Southwest show lesser weather/mortality relationships in summer. During winter, air mass-induced increases in mortality are considerably less than in summer. Although daily winter mortality is usually higher than summer, the causes of death that are responsible for most winter mortality do not vary much with temperature. Using models that estimate climate change for the years 2020 and 2050, it is estimated that summer mortality will increase dramatically and winter mortality will decrease slightly, even if people acclimatize to the increased warmth. Thus, a sizable net increase in weather-related mortality is estimated if the climate warms as the models predict.
Inguinal Hernia: The Imperfectly Descended Testicle and Varicocele.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastric and Duodenal Ulcer
Authors: Bertram W. Sippy
Journal: JAMA (1983)

Favored by unusual clinical facilities, I have gradually evolved and established in practice a method of treating gastric and duodenal ulcers. The method is based on well-recognized principles underlying the healing of ulcer. Old and established facts of physiology are largely utilized. The results of treatment are far beyond early expectations. The treatment consists essentially in accurately protecting the ulcer from gastric juice corrosion until healing of the ulcer takes place. After an experience of twelve years in applying the principle involved in the treatment, I am convinced that the vast majority of cases of gastric, and more particularly duodenal, ulcer now treated surgically, and with indications commonly accepted as justifiable, can be readily and more quickly cured by the management advocated. As I understand the ulcer problem, the principles involved in treatment are centered about these important and fundamental questions: What are the causes of peptic ulcer?