tbuckley/cabot-search huggingface dataset:
Physician Leadership Awards
Journal: JAMA (1995)

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Parotid Biopsy
Authors: Harry J. Tamoney
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Superficial parotidectomy should be the minimum operative procedure for biopsy of any nodule or swelling of the parotid gland. Anything short of that is dangerous. The ease of identification of the seventh cranial nerve as it emerges from the stylomastoid foramen of the skull and its subsequent skeletonization and careful preservation have dispelled the fears and anxieties of yesteryear's surgeons. By eliminating the common practice of enucleating or shelling out of parotid nodules without any attempt at identifying the facial nerve, the danger of injury to the facial nerve is diminished, as is the spreading or seeding of tumor. All procedures more limited in scope than removal of a lobe of the parotid gland for an undiagnosed swelling should be discarded. One does not hesitate to remove a lymph node from the axilla, groin, or any other peripherally accessible area for study. Any unexplained unilateral parotid swelling
Acute monoarticular arthritis. A diagnostic approach
Authors: J. F. Freed
Journal: JAMA (1980)

A group of adult patients with acute nontraumatic monoarticular arthritis was studied. Using only the traditional clinical tools of history, physical examination, joint x-ray films, and synovial fluid culture, Gram's stain, and examination for crystals, 74% of the diagnoses made were achieved either immediately or within two to three days. Overall, 64% of the cases were diagnosed during follow-up. Other tests were not found to be helpful in the acute situation and should be utilized only if the tests already mentioned fail to yield a diagnosis. The prognosis of patients with acute monoarthritis that remains undiagnosed after thorough evaluation is generally good. (<i>JAMA</i>243:2314-2316, 1980)
AN INTERPRETATION OF SOME INTESTINAL FACTORS IN EXPERIMENTAL SCURVY
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigational exemption procedures for new drugs
Authors: H. E. Simmons
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma
Authors: J. Curtis
Journal: JAMA (1972)

Hyperosmolar hyperglycemic nonketotic coma developed in a patient with diabetes mellitus. Essential hypertension followed the addition of chlorthalidone to his usual medication. Profound hyponatremia, sustained insulin-resistant hyperglycemia, and hyperuricemia were atypical findings attributed to the pharmacologic properties of chlorthalidone.
Clinical Pulmonary Physiology
Authors: Edward A. Gaensler
Journal: New England Journal of Medicine (1955)

Ventilation and Gas Exchange at RestThe tidal volume is the amount of air moved through mouth and nose with each breath. Minute ventilation is obtained by addition of all tidal volumes exchanged during one minute. The easily measured minute ventilation is not an informative expression of the quantity of air available to the alveolar surface for gas exchange. With each inspiration the dead-space air within the respiratory passages must be flushed into the lungs before ambient air can reach the breathing space. This dead-space volume, usually 100 to 150 cc.,103 must be subtracted from the tidal volume before effective . . .
Omitted Disclosure of Potential Conflicts of Interest
Authors: Falk Leichsenring, Christiane Steinert
Journal: JAMA (2018)

compulsive disorder and sleep disorders, CBT is virtually the only treatment that has been studied in randomized clinical trials.This does not necessarily imply that other treatments are not efficacious or less efficacious than CBT.With regard to bulimia, most studies do not show that CBT is superior to, for example, psychodynamic therapy. 5 With response rates of about 50% or less and even lower remission rates, CBT cannot claim to be a panacea.Patients who do not benefit sufficiently from CBT may benefit from other psychotherapies.In pharmacotherapy, for example, a patient who does not sufficiently respond to a specific selective serotonin reuptake inhibitor may be offered an alternative medication.Thus, a plurality of approaches not only including the variants of CBT mentioned by van Emmerik and colleagues but also the variants of other evidence-based approaches is needed to offer all patients helpful treatment.A plurality of different approaches allows better care for patients and possible further treatment improvements. 4No form of psychotherapy may presently claim to be the best for all patients.Thus, we agree with DeRubeis and Lorenzo-Luaces 6 who stated: "If the question at hand is whether research is far enough along to support the view that only CBTs should be investigated, taught in training programs, and offered to individuals with mental health problems, then the answer is clearly 'no'."
Abstract A52: Dissection of cancer cells extravasation through human vascularized 3D microfluidic model: The major role of talin-1
Authors: Mara Gilardi, Simone Bersini, Roger Dale Kamm, Matteo Moretti, Marco Vanoni
Journal: Cancer Research (2016)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR07) of the Conference Proceedings. Citation Format: Mara Gilardi, Simone Bersini, Roger Dale Kamm, Matteo Moretti, Marco Vanoni. Dissection of cancer cells extravasation through human vascularized 3D microfluidic model: The major role of talin-1. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr A52.
Questions and Answers
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE INCORPORATION OF THE PAN-AMERICAN MEDICAL CONGRESS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of the Mutagenicity and Carcinogenicity of Motor Vehicle Emissions in Short-Term Bioassays
Authors: Joellen Lewtas
Journal: Environmental Health Perspectives (1983)

Incomplete combustion of fuel in motor vehicles results in the emission of submicron carbonaceous particles which, after cooling and dilution, contain varying quantities of extractable organic constituents. These organics are mutagenic in bacteria. Confirmatory bioassays in mammalian cells provide the capability of detecting chromosomal and DNA damage in addition to gene mutations. In order to evaluate the mutagenicity of these organics in mammalian cells, extractable organics from particle emissions from several diesel and gasoline vehicles were compared in a battery of microbial, mammalian cell and in vivo bioassays. The mammalian cell mutagenicity bioassays were selected to detect gene mutations, DNA damage, and chromosomal effects. Carcinogenesis bioassays conducted included short-term assays for oncogenic transformation and skin tumorigenesis. The results in different assay systems are compared both qualitatively and quantitatively. Good quantitative correlations were observed between several mutagenesis and carcinogenesis bioassays for this series of diesel and gasoline emissions.
Manson's Tropical Diseases. A Manual of the Diseases of Warm Climates.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2459: Identifying genetic drivers of uterine serous carcinoma patient prognosis with regulatory network analysis
Authors: Emily Myers, Lynn K. Tran, Paul M. Tran, David Mysona, Sharad Purohit, J. J. Wallbillich, Jin-Xiong She
Journal: Cancer Research (2019)

Abstract Uterine serous carcinoma (USC) is a subtype of endometrial cancer (EC), which is the most common gynecological malignancy in the developed world. Though USC is a Type II EC, which are only responsible for 20% of EC cases, Type II EC causes 74% of EC deaths. Understanding the molecular mechanisms driving USC tumor biology could reveal novel therapies and improve patient outcomes. We developed and validated gene expression signatures capable of predicting USC patient’s prognosis. However, little was understood about why differential expression of these particular genes predicts patient prognosis. As such, we investigated the key transcription factors driving the phenotypic difference between the two groups by using the Passing Attributes between Networks for Data Assimilation (PANDA) algorithm. As described by Glass et al., PANDA uses message passing to integrate information from multiple data types to construct robust interaction networks between transcription factors and genes. Following regulatory network generation, we selected potential key regulators based on network analyses. First, we use linear regression analysis to select TFs involved in gene interactions with the greatest edge weight differential between the two groups. Second, we identify TFs involved in unique regulatory interactions to each group. Third, we analyze the TF-gene signature gene interaction networks for both patient populations to select hub transcription factors. TFs selected in all three analyses as potential key regulators are ranked using summed residual values to determine in which patient group the TFs were weighted more strongly. A literature review revealed that the TFs most heavily weighted in the poor survival group are implicated as suppressors of tumor growth. The TFs most heavily weighted in the good survival group are implicated in promoting tumor growth. This suggests that fast-growing tumors correlate with good survival and slow-growing tumors correlate with poor survival. We hypothesize that this effect is due to the impact of tumor growth rate on chemosensitivity, and we plan to test this hypothesis in future studies. Citation Format: Emily Myers, Lynn K. Tran, Paul M. Tran, David Mysona, Sharad Purohit, J. J. Wallbillich, Jin-Xiong She. Identifying genetic drivers of uterine serous carcinoma patient prognosis with regulatory network analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2459.
Effect of New AIDS Case Definition on Numbers of Cases Among Homosexual and Bisexual Men in San Francisco
Authors: Warren Winkelstein
Journal: JAMA (1991)

<h3>To the Editor.</h3> —On January 1,1992, the Centers for Disease Control (CDC) is expected to propose that a CD4<sup>+</sup>T-lymphocyte cell count of 200 × 10<sup>6</sup>cells/L or less in a person seropositive for the human immunodeficiency virus (HIV), in the absence of other clinical findings, be added to the list of the acquired immunodeficiency syndrome (AIDS) defining conditions. Some of the consequences of this action can be estimated from data collected in the San Francisco (Calif) Men's Health Study and the San Francisco General Hospital Cohort. These cohorts comprise approximately 1250 homosexual and bisexual men recruited in 1983 and 1984 by a combination of sampling and volunteer procedures. Both cohorts have been examined regularly since recruitment and CD4<sup>+</sup>T-lymphocyte counts have been determined at each examination. By the end of 1990,271 cases of AIDS meeting the 1987 criteria defined by the CDC had been diagnosed. If the proposed
Corrections
Authors: S Hirohata, Y Miura, T Tomita, H Yoshikawa
Journal: Annals of the Rheumatic Diseases (2009)

studies also demonstrated that the suppression of KLF-5 by silencing RNA resulted in a reduction of NFkB1 mRNA in IEC6 cells stimulated with lipopolysaccharide, indicating that KLF-5 is an upstream regulator for NFkB1 mRNA expression in IEC6 cells. 7Taken together, it is most likely that the upregulation of KLF-5 mRNA expression might lead to the enhanced expression of NFkB1 mRNA in BM CD34+ cells, but not vice versa, in RA.In addition, the upregulation of KLF-5 mRNA as well as NFkB1 mRNA in RA BM CD34+ cells might result in their abnormal capacities to differentiate into fibroblast-like cells.In summary, we demonstrate that KLF-5 mRNA expression is upregulated in BM CD34+ cells independently of the systemic inflammation or treatment regimen in RA.Although it is strongly suggested that KLF-5 might be an upstream regulator of NFkB1 mRNA in BM CD34+ cells, further studies to explore the mechanism of abnormal expression of KLF-5 mRNA in BM CD34+ cells would be important for a complete understanding of the pathogenesis of RA.
Activated coagulation time of whole blood
Authors: P. G. Hattersley
Journal: JAMA (1966)

The determination of the coagulation time of whole blood, as usually performed, has proven an inadequately sensitive means of detecting hemorrhagic diatheses. Many patients with low-grade but potentially dangerous hemophilioid disorders show clotting times well within the normal range. This insensitivity results from two well-established characteristics of the coagulation mechanism: (1) Contact activation, the first and clinically least important stage of the process, requires most of the time of coagulation. (2) Unavoidable variations in degree of contact activation in drawing and observing the blood obscure any but the greatest increases in time of the shorter and more important stages of the process. Insensitivity is therefore inherent in the measurement of coagulation time unless one either eliminates the period of contact activation or, at least, drastically and uniformly shortens it. Many workers have used particulate materials with large surface area to effect quick and maximal contact activation of plasma. In 1958
National Conference on Radiation Oncology and National Conference on Cancer Research and Clinical Investigation
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article National Conference on Radiation Oncology and National Conference on Cancer Research and Clinical Investigation Get access JNCI: Journal of the National Cancer Institute, Volume 55, Issue 2, August 1975, Page 499, https://doi.org/10.1093/jnci/55.2.499-c Published: 01 August 1975
Wit: A Play Raises Issues of Emotional Needs of Patients
Authors: M. J. Friedrich
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRACTION STRATEGY WITH CLIPS AND RUBBER BAND ALLOWS COMPLETE EN BLOC ENDOSCOPIC SUBMUCOSAL DISSECTION OF LATERALLY SPREADING TUMORS INVADING THE APPENDIX
Authors: M Pioche, J Rivory, J Jacques, T Ponchon
Journal: Endoscopy (2018)

Endoscopic submucosal dissection is now the reference method to allow En Bloc resection of large colorectal neoplasia. Nevertheless, appendix invasion is still considered a contraindication of resection because of the risk of perforation and the difficulty to find the dissection space at the bottom of the appendix. We report here the case of a 72 years old men referred for resection of a 4 cm granular LST of the cecum invading deeply the appendix orifice.
Tryptophan
Authors: Claude O. Burdick
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Dr Lahmeyer's<sup>1</sup>response to an inquiry on the safety of tryptophan use doubtless was prepared prior to the recent cases of tryptophaninduced hypereosinophilia syndrome (<i>San Francisco Chronicle</i>. November 14, 1989:3). One can be certain he would now upgrade his "lack of enthusiasm" to condemnation. During the present epidemic we have seen five cases. One was a woman who took 1500 mg/d of tryptophan along with 150 mg/d of amitriptyline. She entered the hospital with congestive heart failure, joint pains, and a headache. Her peripheral leukocyte count was 43 × 10<sup>9</sup>/L and showed 0.80 eosinophils, of which 12% had three or four lobes, a finding that does not usually occur except under the stress of folate or B<sub>12</sub>deficiency.<sup>2</sup>Our patient's folate level was 9.9 nmol/L (4.1 to 20.4 nmol/L), and her B<sub>12</sub>level was 697 pmol/L (74 to 516 pmol/L), values that