tbuckley/cabot-search huggingface dataset:
Intestinal Hemorrhagic Necrosis in Aortic Insufficiency
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Late Dr. Grafton Tyler.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurosurgery, 1941–1950
Authors: Donald Munro
Journal: New England Journal of Medicine (1950)

Surgical Intracranial InfectionBrain AbscessAs was to be expected with the advent of the sulfonamide drugs and the antibiotics, interest in the strictly neurosurgical infections of the central nervous system and its coverings has increased greatly in the past nine years. The therapy of brain abscess in particular has had an interesting evolution. In 1941, the premise that the therapeutic possibilities of encapsulated and unencapsulated abscesses could not and should not be the same in detail was generally recognized. It was held that treatment of the first should be by surgical drainage from within the capsule as exemplified by . . .
Announcement
Authors: David Smith, Andor Szentivanyi, Charles Fishel, Joseph Krzanowski, James Polson, David Mathison, D Stevenson, E Tan, John Vaughan, Constantine Falliers, Colo Bronchodilator, Miles Weinberger, Edwin Bronsky, Ralph Bookman, Edward Katz, Harold Rosengren, Beverly Hills, Vincent Derbes, William Coleman
Journal: Journal of Allergy and Clinical Immunology (1972)
Surrogate Consent for Live Organ Donation—Reply
Authors: The Writing Committee of the UCLA Medical Center Ethics Committee and UCLA Renal Transplant Program
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AN APPEAL TO NEW YORK.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Handbook of the Diagnosis and Treatment of the Diseases of the Throat Nose; and and Naso-Pharynx.
Authors: None W. E. C.
Journal: JAMA (1889)

The author is a careful observer and a concise and accurate relator, and, rarer still in medical authorship, a master of the difficult art of omission The result is a handbook which will be read throughout with pleasure and profit by thousands, to whom the more exhaustive treatises are of service for occasional reference only. Much space, proportionately, is devoted to the anatomy and physiology of the upper respiratory passages, and to laryngoscopic and rhinoscopic technique, including the various methods of electrical illumination. Preference is accorded to the electric incandescent light, which has been made available even to those not upon a regular light circuit, by the introduction of storage batteries, one of which, suitable for this purpose, is figured and described. A new chapter on acoustics, voice production, and articulation, imparts a halo of originality to this part of the volume and is especially acceptable, inasmuch as the author
BOOK REVIEWS
Authors: L. SCHUCHTER
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article BOOK REVIEWS Get access Leukolysins and Cancer Janet H. Ransom John R. Ortaldo eds. Clifton, NJ : Humana Press , 1988 , 322 pp. $69.50. LYNN SCHUCHTER LYNN SCHUCHTER Hematology-Oncology Section Hospital of the University of Pennsylvania6 Penn Tower 3400 Spruce St Philadelphia, PA 19104 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 24, 19 December 1990, Page 1938, https://doi.org/10.1093/jnci/82.24.1938 Published: 19 December 1990
Esophageal Diverticulum
Authors: David P. Boyd, Herbert D. Adams
Journal: New England Journal of Medicine (1961)

THIS report is derived from a background of 437 cases of esophageal diverticula, from 1925 to January, 1960. Of this number 425 were pharyngoesophageal, and 12 were supradiaphragmatic diverticula. Over the years a series of articles from this clinic has strongly championed two-stage excision of this lesion. As shown below, the mortality has been so low (0.45 per cent) that it was exceedingly difficult for us to persuade ourselves to abandon this two-stage operation. Recently, however, it has seemed wise for several reasons to join the trend toward one-stage removal. The reason for this lies only partly in recent advances . . .
Ratio of Mutant JAK2-V617F to Wild Type Jak2 Determines the MPD Phenotypes in Transgenic Mice.
Authors: Ralph Tiedt, Hui Hao-Shen, Marta A. Sobas, Renate Looser, Stephan Dirnhofer, Jürg Schwaller, Radek C. Skoda
Journal: Blood (2007)
Correction
Journal: BMJ (1964)

To-day's Drugs MILJOU 239therapy.The main side-effects are postural hypotension or giddiness, lassitude, exertional hypotension, failure of ejacula- tion, and limb weakness.In a third of these cases the side- effects disappeared in spite of continuous therapy.Diarrhoea was noted in eight out of 200 cases, but disappeared in four after continued therapy.The main problem is the effect on S.G.O.T. and S.G.P.T., but the significance of these enzyme changes is not yet known.In summary, guanoclor is an effective antihypertensive agent, especially in combination with a thiazide diuretic, and should be taken into consideration when considering initiation of antihypertensive drug treatment.It is not the ideal drug, because it is not universally effective or free from side-effects; this, of course, applies equally to all the other potent anti- hypertensive agents available.Judgment on its toxicity must be reserved until further reports on the significance of the occasional elevation of
P04.79 Cytotoxic T cells and their activation status are independent prognostic markers in meningiomas
Authors: C C Herold-Mende, C Rapp, C Jungk, F Sahm, K Lamszus, R Ketter, M Löhr, C Senft, M Westphal, A von Deimling, A Unterberg, M Simon
Journal: Neuro-Oncology (2018)

Although clinically aggressive meningiomas (MGMs) are rare tumors, more effective therapies are urgently needed. As a prerequisite for successful immunotherapy we determined the infiltration and activation status of T cells in primary (p-) and recurrent (r-) MGMs and their impact on survival. Presence of tumor-infiltrating lymphocytes (TILs) was assessed in a large, clinically well-annotated study sample of 202 cases (n=123 pMGMs, and n=79 rMGMs) with a substantial proportion of higher-grade MGMs (n=43 WHO°I, n=97 WHO°II, n=62 WHO°III). TIL quantification was performed by a semi-automated analysis on whole tissue sections stained by multi-color immunofluorescence for CD3, CD8, FOXP3, and PD-1. Ranging from 0.01–24.88 %, median T cell infiltration accounted for 0.59 TILs per total cell count (TCC). Although there were no significant changes for the proportion of helper and cytotoxic T cells in pMGM of different WHO grades, higher numbers of cytotoxic T cells were associated with an improved progression-free survival (PFS) independent of prognostic confounders. rMGM were characterized by significantly lower numbers of TILs in general (median: 0.33 % per TCC), helper and cytotoxic T cells and a significant increase of regulatory T cells. As for the activation of TILs, about one third expressed the immune checkpoint molecule PD-1 and predominantly were CD8-positive. We observed a significant WHO-dependent decrease of PD-1+/CD8+ TILs which in univariate and multivariate analyses were associated with a poorer PFS. In line with these findings proportions of PD-1+/CD8+ TILs were significantly lower in rMGM arguing for PD-1 as an activation rather than an exhaustion marker. In summary, we were able to identify intratumoral cytotoxic TILs as well as of PD-1-expressing cytotoxic TILs as novel and easy applicable biomarkers for a better survival, which might facilitate the selection of patients who could benefit from immunotherapeutic approaches and mandates for an intervention in primary rather than recurrent tumors.
Highlights
Journal: JAMA Psychiatry (2018)

Drug development in psychotic disorders is hampered by a lack of functional targetengagement biomarkers.Javitt and colleagues evaluated ketamine-evoked changes in functional magnetic resonance imaging blood oxygen level-dependent response, glutamate proton magnetic spectroscopy, and task-based functional magnetic resonance imaging in brain glutamate in 65 healthy volunteers across 3 sites and found a highly significant increase in functional magnetic resonance imaging blood oxygen level-dependent response that was consistent across sites.In an Invited Commentary, Kraguljac and Lahti discuss the implications of these findings for new drug development efforts.
SEED OILS AS NUTRIENTS
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Iatrogenic Bleeding
Authors: Jay L. Jenkins
Journal: JAMA (1974)

<h3>To the Editor.—</h3> We have recently seen a problem that we think should be called to the attention of practitioners throughout the country. A 24-year-old man, previously in good health, had been donating plasma at a local collecting center. It was noted that clotting at the venipuncture site failed to occur, even after considerable time. At the local emergency room, clotting studies revealed an activated partial thromboplastin time (APTT) of 71 seconds (normal, less than 45 seconds). The coagulation time was 71 minutes. Other clotting studies, including prothrombin time, platelets, and fibrinogen, gave normal results. Shortly afterwards, he ceased to have bleeding from the venipuncture site, but was kept in the hospital overnight. By the next morning, the APTT and coagulation time had reverted to normal. The patient was discharged and since has had no difficulty. The collecting agency told us that they had recently received a directive from their
114th Annual Convention of the American Medical Association
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Textbook on Surgery for Students and Physicians
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart
Authors: M. J.A. Van Kempen, J. L.M. Vermeulen, A. F.M. Moorman, D. Gros, D. L. Paul, W. H. Lamers
Journal: Cardiovascular Research (1996)

Gap junctions have been demonstrated ultrastructurally in cardiac regions where connexin40 (Cx40) and connexin43 (Cx43) protein could not be detected immunohistochemically. We investigated therefore the distribution of their mRNAs with more sensitive techniques. Methods: In situ hybridizations with Cx40 and Cx43 cRNA probes were performed on sections of rat hearts from 9 embryonic days (ED 9) to adults. Results: From ED 13, Cx40 and Cx43 mRNA are detectable in atria and ventricles, but not in their flanking myocardium (inflow tract, atrioventricular canal and outflow tract). Even though Cx40 and Cx43 mRNA eventually become expressed in the inflow tract, they remain undetectable in the sinoatrial node, the atrioventricular canal (including atrioventricular node) and outflow tract. Expression of Cx40 is maximal in the fetal period and declines towards birth. Cx40 expression in the left and right ventricles evolves independently, its mRNA disappearing 4 days earlier from the right than from the left ventricle, and earlier from the free wall than from the trabeculations. Expression of Cx43 mRNA increases during development and changes postnatally from uniform to punctate. Prenatally, Cx43 mRNA was strongest in the subepicardial layer of the ventricular free wall. Nevertheless, we did not detect protein in this layer. Conclusions: Cardiac regions without detectable Cx40 or Cx43 mRNA either have extremely low levels of expression or express a different connexin. The temporally separate disappearance of Cx40 mRNA from the fetal ventricles implies that left and right ventricles mature independently with respect to gap-junctional communication. The division of the developing heart in compartments where Cx40 and Cx43 mRNA can and cannot be detected, implies pretranslationally regulated gene expression. The postnatally observed subcellular redistribution of Cx43 mRNA coincides with a reported increase in protein expression.
Abstract 4869: Chromosomal and telomeric biomarkers of normal tissue injury to evaluate risk of secondary malignancy following IMRT for prostate cancer
Authors: Jared J. Luxton, Miles J. McKenna, Lynn Taylor, Gregory P. Swanson, Susan M. Bailey
Journal: Cancer Research (2019)

Abstract An overall intent of radiotherapy is to precisely target tumor cells, while minimizing exposures to surrounding normal tissue. Despite successes, there is growing concern that an unacceptably large volume of normal tissue is unavoidably exposed. Chromosome aberrations provide a direct measure of ionizing radiation (IR)-induced DNA damage, as well as an indirect measure of future risk since they are associated with virtually all known cancers. Such structural variants (SVs) include translocations (rearrangements between chromosomes) and inversions (rearrangements within chromosomes), the latter being recently identified as part of a distinctive mutational signature associated with radiation therapy-induced second malignancies. Directional Genomic Hybridization (dGH), is a strand-specific cytogenomics-based methodology for cell-by-cell, high-resolution detection of all SVs, particularly inversions, which when combined with compatible subtelomere probes (Telo-dGH), can be used to distinguish inversions from recombination events (sister chromatid exchange) involving chromosomal termini. Telomeres are critical structural elements that serve to protect the physical ends of chromosomes. Dysfunctional telomeres are associated with instability and carcinogenesis, as well as with a variety of other age-related pathologies (e.g., cardiovascular disease). We are validating Telo-dGH as a prospective “personalized” approach of evaluating normal tissue injury, and therefore future risk, associated with radiation therapy - regardless of tumor type or treatment modality. Here, we report results of monitoring prostate cancer patients before and after intensity-modulated radiation therapy (IMRT) to assess radiosensitivity (toxicity), as well as risk of secondary malignancy and other degenerative late effects. Such a strategy has the potential to better inform patient treatment and management decisions based on predicted individual risk. Citation Format: Jared J. Luxton, Miles J. McKenna, Lynn Taylor, Gregory P. Swanson, Susan M. Bailey. Chromosomal and telomeric biomarkers of normal tissue injury to evaluate risk of secondary malignancy following IMRT for prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4869.