tbuckley/cabot-search huggingface dataset:
PWE-070 Intratumoural variability in prostaglandin E2 levels in human colorectal cancer liver metastases is associated with differences in NAD+ levels and expression of NAD+-dependent 15-prostaglandin dehydrogenase
Authors: A L Young, G Hawcroft, R Chalmers, G J Toogood, M A Hull
Journal: Gut (2010)

<h3>Introduction</h3> Cyclooxygenase (COX)-2 (synthesis) and NAD+-dependent 15-prostaglandin (PG) dehydrogenase (15-PGDH; catabolism) are rate-limiting enzymes in control of tissue PGE2 levels. COX-2 and 15-PGDH function may be affected by the tumour micro-environment (eg, hypoxia) leading to changes in local PGE2 concentration and altered cancer cell behaviour. Epithelial-mesenchymal transition (EMT) is believed to be crucial for tumour cell invasion/metastasis. EMT is promoted by PGE2 in several cell types in vitro. We investigated the relationship between PGE2 levels, COX-2 and 15-PGDH expression, and NAD+ levels in human colorectal cancer liver metastases (CRCLM), and the role of hypoxia and PGE2 in EMT of CRC cells in vitro. <h3>Methods</h3> PGE2 and NAD+ levels, and immunoreactive 15-PGDH and COX-2 protein content, were measured in paired central and peripheral tissue from 20 CRCLM. 15-PGDH activity was measured by a [<sup>3</sup>H]-PGE2 degradation assay in the presence or absence of exogenous NAD+ (1 μM). Parallel in vitro studies used a LIM1863 human CRC cell model of transforming growth factor (TGF) β-induced EMT and MCF-7 human breast cancer cells. <h3>Results</h3> PGE2 levels were increased by a mean (95% CI) of 26% (1% to 52%) in the centre of CRCLM relative to peripheral tissue (mean 762 vs 604 pg/mg). Counter-intuitively, immunoreactive 15-PGDH protein levels were also increased (14% (3% to 27%)) in tumour centres, as was 15-PGDH activity in the presence of added NAD+ (16% (3% to 29%)). However, NAD+ levels were 59% (25% to 72%) lower in the centre of CRCLM than the periphery (mean 192 vs 546 pmol/mg) suggesting inefficient 15-PGDH-dependent catabolism may explain raised PGE2 levels. By contrast, there were no significant regional differences in immunoreactive COX-2 protein levels. In central areas of CRCLM, cancer cells exhibiting low E-cadherin expression had higher 15-PGDH expression than neighbouring E-cadherin-positive cells. Our CRCLM tissue observations were mirrored by LIM1863 cells undergoing EMT as hypoxic (1% O2) LIM1863 cells contained significantly less NAD+ and exhibited higher 15-PGDH protein levels than normoxic cells. 15-PGDH activity was significantly decreased in hypoxic MCF-7 cells compared with normoxic counterparts when NAD+ was present at a limiting concentration (no exogenous added). Furthermore, PGE2 (0.1–10 μM) promoted TGF-β-induced EMT in LIM 1863 cells in a concentration-dependent manner. <h3>Conclusion</h3> Regional differences in PGE2 levels and 15-PGDH expression/activity are apparent in human CRCLM (possibly due to a hypoxic micro-environment). PGE2 promotes TGF-β-induced EMT in human CRC cells in vitro. Modulation of factors controlling PGE2 represents a novel therapeutic strategy against EMT in CRCLM.
ANGIONEUROTIC EDEMA.
Journal: JAMA (1902)

The more or less sudden appearance of edematous swellings in various parts, most frequently in the subcutaneous tissue, in persons with "nervous" tendencies, has led to the establishment of angioneurotic edema. As indicated by the name it is thought that the underlying condition is some form of disturbance in the innervation of the blood vessels. Kohn<sup>1</sup>reports a case and reviews the literature. In Kohn's case the dipping of the hands in hot water brought on the edema; in previous cases the influence of cold in bringing on the circumscribed edematous swellings has been noted. Alcohol, trauma and malaria have also been regarded as of etiologic importance. In not a few cases the disease has manifested a distinct tendency to appear in families, affecting various members and generations of the same family. Associated pathologic conditions are usually not apparent, the swellings being recurrent and transitory. As indicated, they usually
Association News
Authors: George S. Davis
Journal: JAMA (1925)

<h3>THE ATLANTIC CITY SESSION</h3> Fort Riley Reunion Association Owing to the probably small attendance of Fort Riley men at the Atlantic City session, and also to the fact that a general reunion of all medical officers of the World War has been arranged for Wednesday evening, it has been considered advisable to omit the special Fort Riley reunion this year. All Fort Riley men who may attend the session are urged to attend the general reunion of service men at the Ritz Carlton Hotel at 7 o'clock Wednesday evening, May 27. Arrangement for a Fort Riley reunion during the session of the American Medical Association next year will be announced later.
Phase 1–2a dose ranging study of TLK286 (a novel glutathione analog) in combination with liposomal doxorubicin in platinum refractory or resistant ovarian cancer
Authors: G. L. Brown, L. Lewis, H. Choi, R. Iyer, C. Moore, A. Valmonte, A. Jameson, J. Keck, K. Patel, J. Kavanagh
Journal: Journal of Clinical Oncology (2004)

5062
The Pocket Materia Medica and Therapeutics.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA-RPS Heard in the AMA's House of Delegates
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correcting the literature following fraudulent publication
Authors: P. J. Friedman
Journal: JAMA (1990)

To gain a better understanding of the problem of dealing with publications whose integrity is subsequently challenged, experience in a well-documented case of research fraud was reviewed. At the University of California San Diego, a faculty committee evaluated 135 publications of Robert Slutsky, MD, and reported to each of the corresponding 30 journals whether each article was<i>valid</i>, questionable, or<i>fraudulent</i>, requesting publication of the criteria and the conclusions. Journals responded slowly to this request; half required additional letters over a 2-year period to elicit a reply. Of the 13 journals that had<i>only</i>valid articles, 5 printed a statement to that effect. Statements concerning 46 of 60 nonvalid articles were eventually published. Journals' inconsistent identification of published statements made it difficult to retrieve them by electronic searching. Only 7 notices covering 15 articles were found by searching under the Medical Subject Heading "Retraction of Publication"; scanning the entire bibliography retrieved 18 articles with retraction notations. A poll showed that journals rarely have written procedures for responding to allegations of research misconduct; in our experience, journals were reluctant to accept authorized retractions or corrections when coauthors failed to act. (<i>JAMA</i>. 1990;263:1416-1419)
Soviet medical response to the Chernobyl nuclear accident
Authors: R. E. Linnemann
Journal: JAMA (1987)

The nuclear accident at Chernobyl was the worst in the history of nuclear power. It tested the organized medical response to mass radiation casualties. This article reviews the Soviet response as reported at the 1986 postaccident review meeting in Vienna and as determined from interviews. The Soviets used three levels of care: rescue and first aid at the plant site; emergency treatment at regional hospitals; and definitive evaluation and treatment in Moscow. Diagnosis, triage, patient disposition, attendant exposure, and preventive actions are detailed. The United States would be well advised to organize its resources definitively to cope with future nonmilitary nuclear accidents. (<i>JAMA</i>1987;258:637-643)
Scleromyxoedema
Authors: Raj Kubba, R.H. Champion
Journal: British Journal of Dermatology (1975)

Journal Article Scleromyxoedema Get access Raj Kubba, Raj Kubba Addenbrooke's Hospital, Cambridge Search for other works by this author on: Oxford Academic Google Scholar R.H. Champion R.H. Champion Addenbrooke's Hospital, Cambridge Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 93, Issue s11, 1 July 1975, Pages 36–38, https://doi.org/10.1111/j.1365-2133.1975.tb06786.x Published: 01 July 1975
Ocreiform Dermatitis
Authors: Frank Piers
Journal: British Journal of Dermatology (1969)

Journal Article Ocreiform Dermatitis Get access Frank Piers Frank Piers Nairobi, Kenya Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 7, 1 July 1969, Pages 558–559, https://doi.org/10.1111/j.1365-2133.1969.tb16036.x Published: 01 July 1969
LATITUDE: A phase III, double-blind, randomized trial of androgen deprivation therapy with abiraterone acetate plus prednisone or placebos in newly diagnosed high-risk metastatic hormone-naive prostate cancer.
Authors: Karim Fizazi, Namphuong Tran, Luis Enrique Fein, Nobuaki Matsubara, Alfredo Rodríguez Antolín, Boris Y. Alekseev, Mustafa Ozguroglu, Dingwei Ye, Susan Feyerabend, Andrew Protheroe, Peter De Porre, Thian Kheoh, Youn C. Park, Mary Beth Todd, Kim N. Chi
Journal: Journal of Clinical Oncology (2017)

LBA3 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Saturday, June 3, 2017, and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Sunday edition of ASCO Daily News.
A Correction
Journal: BMJ (1898)

value of C, and as my weight is z64 lbs., and that of my cycle 36 lbs., I perform the following work in foot tons:(a) In walking I2 miles in 3 hours, 264 X 12 X 5280 I X -= 289.9 foot tons.2240 x6 (b) In cycling 30 miles in 3 hours I do, by assumption, the same amount of work, namely, 289.9 foot tons.What is the value of C, or co-efficient of traction ?(164 + 36) X 30 X 5380 __________-+ 289.9 = C, that is, C = 48.7.2240 Thus, by using the ordinary formula and multiplying, say roughly, by the fraction &,, I think that under the average conditions of roads and weather a fair and tolerably accurate andpractical result may be arrived at as to the work done in cycling.
P2.13-11 EGFR Amplification and Sensitizing Mutations Correlates with Survival from Erlotinib in Lung Adenocarcinoma Patients (MutP-CLICAP¶)
Authors: A. Cardona, A. Ruiz-Patiño, C. Castro, L. Rojas, O. Arrieta, Z. Zatarain-Barrón, H. Carranza, C. Vargas, J. Otero, L. Corrales, C. Martin, R. Rosell
Journal: Journal of Thoracic Oncology (2018)
Monitoring Nitrite, N-Nitrosodiethanolamine, and Mutagenicity in Cutting Fluids Used in the Metal Industry
Authors: Silvano Monarca, Giuseppina Scassellati Sforzolini, Berthold Spiegelhalder, Rossana Pasquini, Cristina Fatigoni
Journal: Environmental Health Perspectives (1993)

We carried out an integrated environmental/biological monitoring program to evaluate cancer hazards among metal industry workers exposed to cutting fluids. Several cutting fluids were sampled according to response to a semiquantitative nitrite rapid test in metal factories in central Italy. The nitrite-positive samples were analyzed for nitrite and nitrosodiethanolamine (NDELA) content and mutagenic activity. The nitrite-negative samples were analyzed only for mutagenicity. Of the total samples, 20.6% were nitrite positive, and all contained NDELA. However, nitrite content was not quantitatively predictive of the NDELA content, which varied enormously among samples (0.3-1900 mg/kg). Nitrite-negative samples were always nonmutagenic. Mutagenicity was found in half the NDELA-containing samples but was not related to nitrite or NDELA content. Nitrite screening of cutting fluids in the field is an interesting method for identifying samples that potentially contain NDELA and other unknown mutagens and, when performed with short-term mutagenicity tests, nitrite screening seems to be a valid tool by which industrial managers and health officers could minimize the health hazards associated with occupational exposure to cutting fluids.
Nouveau traité de psychologie.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Session 11: T-cell lymphomas
Authors: A Shustov, R Advani, P Brice, N Bartlett, J Rosenblatt, T Illidge, J Matous, R Ramchandren, M Fanale, J Connors, Y Yang, E Sievers, D Kennedy, B Pro, J Delabie, H Holte, J Vose, J Armitage, D Weisenburger
Journal: Annals of Oncology (2011)
Tenth Report of the State Board of Health of the State of Maine. 1896-1897.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leaders of Medicine: Biographical Sketches of Outstanding American and European Physicians
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Circulation (2005)

error appears on page 372.In the paragraph that begins, "Furthermore, in the presence of advanced CAD. ..," the last sentence of the paragraph should read, "Aerobic exercise training also may decrease the risk of sudden cardiac death due to ventricular tachyarrhythmias by reducing sympathetic and enhancing parasympathetic (vagal) activity, as evidenced by increased heart rate variability and increased baroreceptor sensitivity. 69 -71"
Inflammatory Bowel Disease
Authors: Stephen B. Hanauer
Journal: New England Journal of Medicine (1996)

In recent years there has been a series of advances in the treatment of inflammatory bowel disease (ulcerative colitis and Crohn's disease).16 Notwithstanding these advances, our understanding of inflammatory bowel disease7 has been hindered by the lack of representative animal models, an absence of pathognomonic features, and inadequate therapeutic end points. Sensitive or specific serologic or genetic markers of inflammatory bowel disease have yet to be identified.7 At present, the diagnosis of ulcerative colitis and Crohn's disease and the differentiation between them are based on nonspecific clinical and histologic patterns that are often obscured by intercurrent infectious or iatrogenic . . .
Hypothermia-Related Deaths—Suffolk County, New York, January 1999–March 2000, and United States, 1979-1998
Journal: JAMA (2001)

Hypothermia is the unintentional lowering of core body temperature to <95 F (<35 C). Core body temperature normally is maintained at 97.7 F (36.5 C). Most hypothermia-related deaths occur during the winter in states that have moderate to severe cold temperatures (e.g., Alaska, Illinois, New York, and Pennsylvania). During 1979-1998, New York had the second highest number of hypothermia-related deaths in the United States. This report presents case reports of four hypothermia-related deaths during January 1999-March 2000 in Suffolk County (1999 population: 1,383,847), the largest county in New York excluding New York City, and summarizes hypothermia-related deaths in the United States during 1979-1998. Such deaths can be prevented by educating health-care providers and the public to identify persons at risk for hypothermia.
Teratological Research Using In Vitro Systems. III. Embryonic Organs in Culture
Authors: Karen E. Whitby
Journal: Environmental Health Perspectives (1987)

A search of literature published through the spring of 1986 yielded approximately 95 citations for the following embryonic organs in culture: kidney, pancreas, skin, palate, craniofacial tissue, tooth, lens, bones, digits, and liver. However, only the in vitro organ culture of the palate and tooth are reviewed in this paper. The other organ culture systems were not reported as teratogenic screens. Although some organs may have the potential for such use, many are currently used for evaluation of the pathogenesis associated with congenital abnormalities, cancer, or transplacental carcinogenesis, or in studies of the structure and function of differentiating organs, and will not be included in this review.
Molecular characterization of hepatocellular carcinoma in Mongolia delineates unique genomic features
Authors: Marc Puigvehí, Daniela Sia, Miguel Torres-Martin, Miho Maeda, Thais Leonel, Huan Wang, Vincenzo Orlando, Mireia Garciá-López, Wei Qiang Leow, Carla Montironi, Sara Torrecilla, Chinbold Enkhbold, Erdenebileg Taivanbaatar, Amankyeldi Yerbolat, Geniś Campreciós, Sofiá Pérez-del-Pulgar, Augusto Villanueva, Swan N Thung, Jigjidsuren Chinburen, Andrew Uzilov, Xavier Forns, Sasan Roayaie, Josep M. Llovet
Journal: Journal of Hepatology (2020)
X-Ray Seminar Number 10
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Relda Cailleau
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Reply Get access Relda Cailleau, D.Sc. Relda Cailleau, D.Sc. Medical Breast Service Department of Medicine Texas Medical Center The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 60, Issue 6, June 1978, Page 1207, https://doi.org/10.1093/jnci/60.6.1207 Published: 01 June 1978