tbuckley/cabot-search huggingface dataset:
Reply
Authors: Jasmohan S. Bajaj, Oliviero Riggio
Journal: Hepatology (2011)

We read with interest the letter by Gitlin, which raises several important points pertaining to the use of rifaximin for hepatic encephalopathy (HE). Long-term use of any antibiotic does carry the risk of resistance; however, the low likelihood of this appearing with rifaximin due to the nonplasmid nature of its resistance was also cited in the article.1 The U.S. Food and Drug Administration (FDA) approval for rifaximin, granted as a result of the same March 2010 meeting that is mentioned in the letter, comes along with the warning, as with all antibiotics, for the continuous monitoring of patients on this therapy for Clostridium difficile.2 The article referred to the differences in the use of rifaximin across countries, cyclical therapy in Italy, and continuous therapy that is being currently used in the United States and presents possible advantages and disadvantages of both approaches. The precedence and scientific merit of this therapy is evident in the publications and the clinical practice in Italy regarding the use of rifaximin, which was referenced in the article.3, 4 Although the points about the adverse events of lactulose as pointed out in the letter are noted and it is also known from clinical experience that rifaximin is well tolerated in patients, prospective evidence using a large-scale, head-to-head comparison of rifaximin compared to lactulose is still awaited.5, 6 Bass et al. indeed demonstrated that administration of rifaximin with lactulose prevented hospitalizations and HE recurrences compared to administration of lactulose alone in patients who had two prior HE episodes, but this needs further evaluation in patients who have had their first HE episode.7 There is also a huge cost difference between rifaximin and lactulose and the evidence that rifaximin reduces overall costs and hospitalizations outside the selected population in the trial by Bass et al. is from retrospective, single-center studies.1, 8, 9 Therefore, to answer these important questions, the FDA has mandated postmarketing trials comparing lactulose and rifaximin for HE and to study rifaximin in patients who have a Model for End-Stage Liver Disease score ≥19.10 Until these trials are completed, from an evidence-based medicine approach, we stand by the recommendations in the article regarding the role of rifaximin Jasmohan S. Bajaj M.D.*, Oliviero Riggio M.D. , * Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Administration Medical Center, Richmond, VA, Department of Clinical Medicine, Center for the Diagnosis and Treatment of Portal Hypertension, Sapienza University of Rome, Rome, Italy.
Chirurgie du sympathique. Chirurgie du tonus musculaire. La section des rameaux communicants.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medication Errors in Children
Authors: Robert L. Poole, William E. Benitz
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paracolic fistulous tracts in diverticulitis and granulomatous colitis
Authors: R. H. Marshak
Journal: JAMA (1980)

GRANULOMATOUS colitis may involve any portion of the large bowel. Although an extensive length of intestine is diseased in many cases, segmental lesions are not uncommon. When segmental disease occurs in patients of middle or old age, it may involve a portion of the colon, usually the sigmoid, where multiple diverticula are also present. Difficulty then arises in differentiating granulomatous colitis from diverticulitis. An unusual feature of both diseases is the presence of a paracolic fistulous tract. Paracolic longitudinal tracts of the sigmoid were originally thought to be secondary only to diverticulitis. In 1970 we<sup>1</sup>reported that paracolic longitudinal tracts also occur in granulomatous colitis, usually in association with diverticula. It was suggested that the transverse fissures of Crohn's disease penetrate the mucosal herniations of the diverticula to produce fistulous tracts. We also postulated that when the tract exceeded 10 cm in length, its presence was pathognomonic for granulomatous colitis.
PLoS Medicine Issue Image | Vol. 2(3) March 2005
Journal: PLoS Medicine (2005)

I have always been drawn to photography because it allows me to step into other people's lives, to exchange stories, and to learn about a myriad of life experiences. Over the years I have photographed a number of individuals with disabilities doing everyday activities like eating a meal, tending to the garden, or taking a walk. In my work, I am interested in challenging societal assumptions about how people navigate through life. This photograph of Megan Shirle is from a series I did in collaboration with Axis Dance Company (www.axisdance.org), an innovative troupe of dancers with and without disabilities. Axis's work redefines our notion of movement and expands our concepts of dance and body image. In my photographs I aspired to capture the elegance and loveliness of composition of their artistic expression. For the past ten years, I have been the senior photographer at the Exploratorium, an internationally renowned museum of science, art, and human perception in San Francisco, California. I have developed installations for several exhibits at the museum including the "Memory" show, the "Revealing Bodies" show, and "Mothlight." I have taught in the undergraduate precollege program at the California College of Arts and Crafts in Oakland, California, and have conducted workshops with kids on probation. I received a BA in German from the University of Michigan-Ann Arbor, and an MFA in Photography with highest distinction from the California College of Arts and Crafts in Oakland, California. Image Credit: Amy Snyder (amys [at] exploratorium.edu)
THE COSTS OF MEDICAL EDUCATION
Journal: JAMA (1931)

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Management of a case of triad syndrome: combined urological and plastic approach
Authors: L. Bizio-Molteni
Journal: JAMA (1970)

An 18-year-old Negro boy with "prune belly" or triad syndrome had a solitary hydronephrotic kidney with an adynamic, massively dilated ureter and bladder. A pyeloileal urinary conduit wa indicated. With the lack of abdominal musculature and wrinkling of the abdominal skin, the usual ileal conduit, flush with the skin, would not allow a constant watertight seal with the urinary collecting device. Surgical management consisted of a pyeloileal conduit with the creation of a spigot-like cutaneous ileostomy which effectively accommodated the collecting device.
3MO IMpassion031: Results from a phase III study of neoadjuvant (neoadj) atezolizumab + chemo in early triple-negative breast cancer (TNBC)
Authors: S. Saji, E. Mittendorf, N. Harbeck, H. Zhang, C.H. Barrios, R. Hegg, A. Koehler, J. Sohn, H. Iwata, M.L. Telli, C. Ferrario, K. Punie, F. Penault Llorca, S. Patel, A. Nguyen Duc, M. Liste Hermoso, V. Maiya, L. Molinero, S. Chui, K.H. Jung
Journal: Annals of Oncology (2020)
Contents
Authors: G Mccaughan, D Baxa, A Thekdi, A Golembieski, P Krishnan, O Sharif, A Kizy, L Shetron-Rama, J Jovanovich, B Chappell, A Snow-Lampart, K Borroto-Esoda, S Gordon, Y Cheng, S Guindon, A Rodrigo, S Lim, L Micco, D Peppa, E Loggi, A Schurich, L Jefferson, C Cursaro, A Panno, M Bernardi, C Brander, F Bihl, P Andreone, M Maini, J Trebicka, E Anadol, N Elfimova, I Strack, M Roggendorf, S Viazov, I Wedemeyer, U Drebber, J Rockstroh, T Sauerbruch, H.-P Dienes, M Odenthal, M Guillaume, A Rodriguez-Vilarrupla, E Rosado, A Mancini, J Bosch, Garcia-Paga ´n
Journal: Journal of Hepatology (2013)
Studies of malabsorption and calcium excretion induced by neomycin sulfate: effect of intestinal site, bile salt, and pancreatic enzymes
Authors: S. J. Gordon
Journal: JAMA (1968)

In studies of the mechanism of neomycin sulfate-induced malabsorption, this drug was administered orally and by tube to the jejunum and ileum in 11 subjects. Studies of fat, calcium, sodium, potassium, and nitrogen excretion were carried out in both urine and feces. Reduction in the steatorrhea was produced by the progressively more distal placement of neomycin. Fecal sodium, potassium, and nitrogen levels were less affected by the site of antibiotic delivery, but the fecal calcium content was greatest with jejunal instillation. Divergence between changes in fecal fat and calcium levels was observed consistently. Urinary calcium, sodium, and potassium levels were frequently greater when neomycin was delivered into the jejunum or ileum than when it was given orally. The administration of bile salts, sodium bicarbonate, and pancreatic enzymes did not consistently affect the steatorrhea.
MEXICO CITY
Journal: JAMA (1920)

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PRAGUE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats</i>: Percentage* of Adult Workers Aged ≥18 Years Who Reported Being Threatened, Bullied, or Harassed While on the Job,† by Sex — National Health Interview Survey, United States, 2010 and 2015§
Authors: Abay Asfaw
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Error bars indicate 95% confidence intervals.† In both 2010 and 2015, adult respondents were asked: "During the past 12 months, were you threatened, bullied, or harassed by anyone while you were on the job?" § Estimates were based on a sample of the U.S. civilian, noninstitutionalized population aged ≥18 years who reported being employed during the week before the interview.Those who did not respond to the question were not included in the denominators when calculating percentages.In 2015, 6.8% of adult workers in the United States reported being threatened, bullied, or harassed on the job during the preceding 12 months, down from 7.8% overall in 2010.The percentage of workers who were threatened, bullied, or harassed declined significantly for women but not for men from 2010 to 2015.In both years, women were more likely than men to report being threatened, bullied, or harassed (9.3% compared with 6.5% in 2010 and 8.0% compared with 5.7% in 2015).
Viral Hepatitis—1975
Authors: Marcel E. Conrad
Journal: JAMA (1975)

VIRAL hepatitis has been recognized as an illness since antiquity. However, it was not until World War II that it was realized that this disease was a commonplace entity. On the basis of epidemiologic data, it was believed that there were two distinct types of viral hepatitis: hepatitis A, or infectious hepatitis, contracted by oral exposure and with a short incubation period (15 to 45 days), and hepatitis B, or serum hepatitis, caused by parenteral exposure and with a long incubation period (50 to 180 days). Recent investigation has shown that (1) other infectious diseases may mimic viral hepatitis (cytomegalovirus, EB virus, toxoplasmosis, infectious mononucleosis), (2) hepatitis A and B may be transmitted by either the oral or the parenteral routes, and (3) there is at least one additional cause of viral hepatitis (hepatitis "C"?), which has an incubation period intermediate to those of hepatitis A and B. The development
Abstract 2959: Deoxysappanchalcone inhibits cell growth by regulation of TOPK signaling pathway in colon cancer
Authors: Ran Zhao, Hai Huang, Bu Young Choi, Mengqiu Song, Fanxiang Yin, Xiaorong Fu, Hanyong Chen, Jung Hyun Shim, Mee-Hyun Lee, Zigang Dong
Journal: Cancer Research (2019)

Abstract Background: Colorectal cancer is one of the most common cancer death causes in the worldwide. Still systemic chemotherapies are limited to many complications and relapse. T-lymphokine-activated killer cell-originated protein kinase (TOPK) is highly expressed and activated in colon cancer, and plays important roles in inflammation, proliferation and survival of cancer cells. Therefore, suppression of the TOPK activity and its downstream signaling cascades is considered to be a rational therapeutic/preventive strategy of colon cancers. Purpose: Deoxysappanchalcone (DSC), a component of Caesalpinia sappan L., is a natural oriental medicine. In the present study, we investigated the effects of DSC on colon cancer cell growth and elucidated its underlying molecular mechanism by targeting TOPK. Study Design and Methods: To evaluate the effects of DSC on colon cancers, we performed cell proliferation assay, propidium iodide- or annexin V-staining analysis and western blotting. Targeting TOPK by DSC was identified by kinase/binding assay and computational docking models. Results: DSC inhibited the kinase activity of TOPK but not mitogen-activated protein kinase (MEK). The direct binding of DSC with TOPK was explored using a computational docking model and binding assay in vitro &amp; ex vivo. DSC inhibited colon cancer cell proliferation, anchorage-independent cell growth, and induced G2/M cell cycle arrest and apoptosis. Treatment of colon cancer cells with DSC induced protein expressions which are involved in cell cycle (cyclin B1) and apoptosis (cleaved-PARP, cleaved-caspase-3 and cleaved-caspase-7), and suppressed protein expressions of extracellular signal-regulated kinase (ERK)-1/2, ribosomal S6 kinase (RSK) or cellular jun (c-Jun) which are regulated by the upstream kinases TOPK. Conclusion: DSC suppresses colon cancer cell growth by direct targeting TOPK-mediated signaling pathway. Citation Format: Ran Zhao, Hai Huang, Bu Young Choi, Mengqiu Song, Fanxiang Yin, Xiaorong Fu, Hanyong Chen, Jung Hyun Shim, Mee-Hyun Lee, Zigang Dong. Deoxysappanchalcone inhibits cell growth by regulation of TOPK signaling pathway in colon cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2959.
Current Trends: Years of Potential Life Lost Before Ages 65 and 85—United States, 1989-1990
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ALCOHOL AND LIQUOR FOR OFFICE AND HOSPITAL USE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health secretary wants to expand NHS services Hospital league tables are misleading Minister orders review of GP's out of hours services BMA responds to CMO's proposals
Journal: BMJ (2000)

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