tbuckley/cabot-search huggingface dataset:
Albumin synthesis rates in cirrhosis: Correlation with Child-Turcotte classification
Authors: P Ballmer
Journal: Hepatology (1993)

Albumin-synthesis rates were measured in nine patients with stable cirrhosis and compared with those of eight healthy volunteers by means of a new technique using stable isotopes. Four grams of L-[1-13C]leucine was injected over 10 min, and blood samples were drawn at intervals. Serum free [13C]leucine enrichment, taken to be the precursor for albumin synthesis, and 13C enrichment of leucine in albumin, isolated with differential solubility in absolute ethanol from trichloroacetic acid–precipitated serum proteins, were measured on mass spectrometry. Albumin synthesis, expressed as a fractional rate, was 7.9% ± 0.3%/day in the controls and 7.9% ± 1.1%/day in the cirrhotic patients. Albumin synthesis, expressed as an absolute rate, was lower in the cirrhotic group (cirrhotic, 119 ± 17 mg/kg/day controls, 146 ± 8 mg/kg/day), but because of the relatively small number of patients the difference was not significant. However, the absolute rate of albumin synthesis significantly correlated with the Child-Turcotte score (p = 0.024) and its Pugh modification (p = 0.027). The rate of albumin synthesis also correlated with serum phenylalanine concentration but not with serum albumin concentration and intravascular albumin mass or with other clinical indexes of liver function or integrity when taken separately. However, the significant correlation between albumin synthesis and Child score suggests that albumin synthesis might be useful for the clinical judgment of patients with cirrhosis. (HEPATOLOGY 1993;18:292–297).
THE THERAPY OF THE COOK COUNTY HOSPITAL
Authors: BERNARD FANTUS
Journal: JAMA (1934)

<h3>THERAPY OF AMEBIASIS</h3><h3>Prophylaxis.—</h3> This must at present be confined to controlling the spread of the cysts outside the body by: 1. Disinfection of the feces and their sanitary disposal, as well as disinfection by boiling of possibly infected water and milk. 2. Avoidance of contaminated foods, such as raw fruits and raw vegetables, and prevention of food contamination by excluding flies and other insects and by periodic examination for cysts of the stools of all persons handling food. 3. Adequate treatment if such persons are found to be carriers of cysts. <h3>Treatment.—</h3> General principles: As the amebas are embedded in the intestinal wall and in certain cases also in the liver, a remedy may be required that reaches them through the blood stream. This is preeminently furnished by the injection of emetine. As amebas are also free in the alimentary tract and these must be reached by the amebicide
TETANY FOLLOWING THYROIDECTOMY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Do adjuvants add to the efficacy and tolerance of bowel preparations? A meta-analysis of randomized trials
Authors: Sophie Restellini, Omar Kherad, Charles Menard, Myriam Martel, Alan Barkun
Journal: Endoscopy (2017)

Correction to: Do adjuvants add to the efficacy and tolerance of bowel preparations? A meta-analysis of randomized trialsEndoscopy eFirstDOI: 10.1055/s-0043-119638
Intervention trial begins with young smokers
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Stavroula Kousta, Katja Brose, Rolf Van Der Sanden, Patrick Scheffmann, Ria Otten, R Adolphs, R Baillargeon, N Chater, P Dayan, S Dehaene, D Dennett, J Driver, Y Dudai, A Engel, M Farah, A Friederici, O Hikosaka, R Jackendoff, P Johnson-Laird, N Kanwisher, M Kutas, N Logothetis, J Mcclelland, E Miller, R Poldrack, M Raichle, T Robbins, A Wagner, V Walsh, Adrian Neal
Journal: Trends in Cognitive Sciences (2011)
Women in Medicine
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Qualitative and quantitative analysis of AgNOR proteins in chemically induced rat liver carcinogenesis
Authors: D Trere
Journal: Hepatology (1996)

A qualitative and quantitative analysis of silver-stained nuclear organizer regions (AgNOR) proteins was performed during hepatocarcinogenesis induced in rats initiated by diethylnitrosamine (DENA) using the resistant-hepatocyte model. Nuclear proteins from control hepatocytes, hyperplastic nodules, and hepatocellular carcinomas (HCC) separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis were transferred to nitrocellulose membranes and specifically silver-stained for AgNOR proteins. No difference was observed in the distribution pattern of the silver-stained bands among control, hyperplastic, or cancer cells. The same was true if human cirrhosis and HCC were compared. The evaluation of individual AgNOR protein amounts by computerized densitometric analysis showed that (1) the integrated optical density value of the total AgNOR proteins was greatest in cancer cells, lesser in hyperplastic hepatocytes, and lowest in control hepatocytes, and (2) the amount of the two major silver-stained proteins, nucleolin (105 kd) and protein B23 (39 kd), was always a constant percentage of total AgNOR proteins. An experiment using bromodeoxyuridine incorporation showed that, during hepatocarcinogenesis, AgNOR protein quantity progressively increased and was significantly related to the increased hepatocyte labeling index. These results show that AgNOR protein distribution changes during hepatocarcinogenesis are caused neither by the synthesis of new AgNOR proteins nor by an unbalanced synthesis of individual AgNOR proteins, but to an increased synthesis of nucleolin and protein B23, which is associated with a progressive increased hepatocyte proliferation rate.
FOURTH OF JULY TETANUS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CONTEMPO '84
Authors: M. THERESE SOUTHGATE
Journal: JAMA (1984)

As knowledge has increased and technology has advanced, medicine has become fragmented into more and more specialties. It is difficult to remain abreast of new happenings in one's own specialty, let alone to view each of the specialties in relation to the entire field of medicine. The situation may in fact be likened to Frank Stella's painting,<i>Sacramento Mall Proposal #4</i>, which appears on this week's cover. The area of knowledge covered by each specialty may be represented by the bands of color that form a square. Each square is partitioned from the adjacent square by thin lines of similar, but paler, color. Although the squares are discrete, they are nevertheless related, not only in shape, but in the fact that they are adjacent wavelengths on the visible spectrum. Looked at individually, each square is simply four bands of a single color; but when the painting is viewed in its
Beta-blocker use in acute myocardial infarction patients with congestive heart failure
Authors: Stephanie W Lui, Carolyn Harper, Rita Redberg
Journal: Circulation (2001)

P49 Background: Beta-blockers have been shown to improve outcomes for patients with acute myocardial infarction (AMI), but have been used reluctantly in AMI patients with congestive heart failure (CHF). However, recent studies have shown that the benefits of beta-blockers outweigh the risks in AMI patients with CHF, and that beta-blockers are a safe and effective treatment for these patients. The purpose of this study is to evaluate the use of beta-blockers in AMI patients with CHF. Methods: A random sample of 4,478 patients aged 65 and older was selected from all fee-for-service Medicare beneficiaries discharged from California hospitals between January to June, 1998 with a principal diagnosis of AMI. After unconfirmed AMI cases and those with unknown discharge status were excluded, there were 2,680 cases for analysis. Results: In this study, 48.2% (1,291) of all AMI patients, and 66.2% (290/438) of those with no contraindications received a beta-blocker. Overall, 40.1% (1,074) had CHF plus other contraindications, and 11.6% (312) had CHF but had no other contraindications. Controlling for age, race, and gender, and compared to those with no contraindications, beta-blocker prescription rates were significantly lower among patients who had CHF as the only documented reason for not prescribing a beta-blocker (OR=0.3, 95% CI=0.3-0.5). Conclusions: Beta-blockers are underutilized in this sample of AMI patients. CHF is an independent predictor for non-prescription of a beta-blocker. Despite evidence from recent studies suggesting its benefit, beta-blocker use is still suboptimal in AMI patients, particularly those with CHF.
'Fresh produce initiative' for imports proposed
Authors: C. Marwick
Journal: JAMA (1997)

TO IMPROVE the safety of imported food, the US government is reaching out to the farm. Plans are being developed to inspect the production sites of fruits and vegetables that come to the United States from abroad as thoroughly as such suppliers are examined in this country. The effort is to ensure food safety at the production level, not just at the import point. If the administration's plans are realized, produce from a country with an inferior food safety system will be banned. This is a fundamental change from current efforts, in which suspect foods are seized at the port of entry. The move comes in the wake of repeated occurrences of foodborne illness from imports and at a time when importation of foods into the United States has been growing rapidly. One estimate is that it has doubled in the past decade. The list of outbreaks of disorders caused
Now Hear This!
Authors: Irvine Â€oe, Morris Fishbein
Journal: CA A Cancer Journal for Clinicians (1966)

â€oe¿ Of all the ghouls who feed on the dying, the cancer quacks are most vicious and most heartless.Heaven speed the day when the advance of medical science against cancer, most dreaded of diseases, will de pi-ive these ghouls of the sad oil on which they nourish themselves.â€•
Effect of guideline based computerised decision support on decision making of multidisciplinary teams: cluster randomised trial in cardiac rehabilitation
Journal: BMJ (2009)

Objective To determine the extent to which computerised decision support can improve concordance of multidisciplinary teams with therapeutic decisions recommended by guidelines.Design Multicentre cluster randomised trial.Participants Multidisciplinary cardiac rehabilitation teams in Dutch centres and their cardiac rehabilitation patients.Interventions Teams received an electronic patient record system with or without additional guideline based decision support.Main outcome measures Concordance with guideline recommendations assessed for two standard rehabilitation treatments-exercise and education therapy-and for two new but evidence based rehabilitation treatments-relaxation and lifestyle change therapy; generalised estimating equations were used to account for intra-cluster correlation and were adjusted for patient's age, sex, and indication for cardiac rehabilitation and for type and volume of centre.Results Data from 21 centres, including 2787 patients, were analysed.Computerised decision support increased concordance with guideline recommended therapeutic decisions for exercise therapy by 7.9% (control 84.7%; adjusted difference 3.5%, 95% confidence 0.1% to 5.2%), for education therapy by 25.7% (control 63.9%; adjusted difference 23.7%, 15.5% to 29.4%), and for relaxation therapy by 25.5% (control 34.1%; adjusted difference 41.6%, 25.2% to 51.3%).The concordance for lifestyle change therapy increased by 3.2% (control 54.1%; adjusted difference 7.1%, -2.9% to 18.3%).Computerised decision support reduced cases of both overtreatment and undertreatment.Conclusions In a multidisciplinary team motivated to adopt a computerised decision support aid that assists in formulating guideline based care plans, computerised decision support can be effective in improving the team's concordance with guidelines.Therefore, computerised decision support may also be considered to improve implementation of guidelines in such settings.
Diagnostic and therapeutic technology assessment. Ablation of accessory pathways in the Wolff-Parkinson-White syndrome
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mutagenicity Testing of 9-N-Substituted Adenines and Their N-Oxidation Products
Authors: J. W. Gorrod, C. Ioannides, S. P. Lam, S. Neville
Journal: Environmental Health Perspectives (1993)

Adenine together with certain 9-N-substituted derivatives such as 9-methyl, 9-benzyl, 9-benzhydryl, and 9-trityl were tested against Salmonella typhimurium strains TA97, TA98, and TA100 in the absence and presence of rat hepatic S9 prepared from Aroclor 1254 pretreated rats.All compounds were positive toward TA98 in the presence of the metabolic activating system, whereas they all lacked mutagenic activity in the absence of S9, and toward TA97 and TA100 with or without S9 when tested at 100 ng/plate.A similar pattern was observed for the corresponding 1-N-oxides.6-Hydroxylaminopurine was not mutagenic toward TA100 at 100 ng/ plate, whereas it was toxic toward TA97 and TA98 at this level.When tested at 1 ng/plate, hydroxylaminopurine was still toxic to TA98 but produced twice the spontaneous reversion rate to TA97 without metabolic activation.Surprisingly, 9-methyl-6-hydroxylaminopurine was only active toward TA98 in the presence of S9, whereas 9-benzyl-6-hydroxylaminopurine was highly active toward TA97 and TA100 in the absence of S9 and even more active in the presence of S9.This compound was inactive toward TA98 in the absence of S9.The results generally support the concept that nuclear N-oxidation of aminoazaheterocycles is a detoxication process, whereas N-hydroxylation of the exo amino group is a toxication reaction.
Value of Mammography and Interest of Its Association with Drill Biopsy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cimetidine postmarket outpatient surveillance program. Interim report on phase I
Authors: L. M. Gifford
Journal: JAMA (1980)

A postmarket surveillance program in outpatients receiving cimetidine was initiated seven months after its approval for marketing. During the first phase of the program, data were obtained over a three-month period for 9,907 patients who received the drug. The overall incidence of adverse effects reported was 4.4%, and the types of adverse effects did not differ from those reported in premarketing controlled studies. Physician response was excellent (85.1%), and the methods used were successful in providing data on a large number of patients who received the drug in routine clinical practice. The results confirmed the safety profile of cimetidine. A follow-up phase, initiated six months after the initial phase of the surveillance program, will provide longer-term data on these patients. (<i>JAMA</i>243:1532-1535, 1980)
From the Food and Drug Administration
Authors: Stuart L. Nightingale
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal