tbuckley/cabot-search huggingface dataset:
Phase 3 trial results for rolapitant, a novel NK-1 receptor antagonist, in the prevention of chemotherapy-induced nausea and vomiting (CINV) in subjects receiving highly emetogenic chemotherapy (HEC).
Authors: Bernardo Leon Rapoport, Allen Poma, Mary Lynne Hedley, Robert E. Martell, Rudolph M. Navari
Journal: Journal of Clinical Oncology (2014)

9638 Background: Rolapitant is a highly selective competitive long acting NK-1 receptor antagonist that demonstrated efficacy and safety in a large randomized phase 2 dose-finding study. This study evaluated the 200 mg dose for efficacy and safety in the prevention of CINV in subjects receiving HEC. Methods: Randomized phase 3 double-blind active-control study. 555 cisplatin-naïve subjects treated with HEC (≥60 mg/m2 cisplatin) were randomized 1:1 to receive either (1) rolapitant + granisetron + dexamethasone or (2) placebo + granisetron + dexamethasone. The primary endpoint was complete response (CR=no emesis and no rescue medication) in the delayed phase (>24-120 hrs) post-chemotherapy. Secondary endpoints included CR during the acute (0-24 hrs) and overall (0-120 hrs) phases. Treatment comparisons were performed using a Mantel-Haenszel chi-square test; to control for the type1 error, testing for the key secondary endpoints was conducted in a stepwise fashion. Subjects recorded episodes of emesis, nausea and rescue medication using a subject diary during 0-120 hours post-chemotherapy. Results: There were 544 evaluable subjects. Subjects in the rolapitant group had a significantly higher CR rate for the primary study endpoint during the delayed phase (70.1% vs 61.9%, p=0.043) compared to control. CR rates were also higher in rolapitant group for acute and overall phases (83.4% vs 79.5%, p=0.233; 67.5% vs 60.4%, p=0.084, respectively). The rolapitant group achieved higher rates of no nausea (maximum Visual Analog scale <5mm, 0-100mm) in both the delayed and overall phases compared to control (58.3% vs 46.9%, p=0.007; 55.0% vs 44.0%, p=0.009, respectively). AE rates were similar across both groups. Conclusions: Rolapitant in combination with a 5-HT3 receptor antagonist and dexamethasone was well-tolerated and demonstrated superior efficacy over control in the primary endpoint of the prevention of delayed CINV in subjects receiving HEC in a global phase 3 study. Clinical trial information: NCT01500213.
Clinical observations of possible barbiturate interference with anticoagulation
Authors: M. G. MacDonald
Journal: JAMA (1968)

Sixty-seven bleeding reactions occurred during anticoagulant therapy. In 14 patients, enzyme induction appeared to be a factor, and two of these patients died. The records were reviewed of 52 patients who were admitted for myocardial infarction and treated with anticoagulants. Forty patients received barbiturates and showed more erratic control of anticoagulant effect (and a shorter prothrombin time in spite of a larger dose of warfarin sodium) than the group not receiving barbiturates. Barbiturate interference with anticoagulant activity of coumarin drugs by enzyme induction is well documented in animals. Circumstantial evidence suggests that it also occurs in man. Awareness of this type of drug interaction and close attention to proper anticoagulant dose based on frequent prothrombin determinations can prevent some of the problems that occur during anticoagulant treatment.
Analgesic-Associated Kidney Disease
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Government-subsidized death and disability
Authors: W. J. Walker
Journal: JAMA (1974)

THE DEATH rate from coronary heart disease suddenly started a sharp decline in 1964 after rising steadily for several decades.<sup>1</sup>The onset of this decline in the leading cause of death in the United States coincided precisely with the Surgeon General's report on smoking and health in January 1964.<sup>2</sup>The decline is among the most dramatic reversals of a mortality trend in our nation's history. From 1950 to 1963, the age-adjusted death rate from coronary heart disease increased 19%. From 1963 to 1971 it fell 10.5%. The most striking reduction has occurred in the most productive years of life—25 to 74 years (Table). According to the National Center for Health Statistics, the decline is continuing. During each of the past four years, we have had the highest life expectancy ever attained in the United States, despite increased death rates from cancer, diabetes, bronchitis, emphysema and asthma, cirrhosis of
Archives Françaises de Pédiatrie, Paris
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A multifactorial system for equitable selection of cadaver kidney recipients
Authors: T. E. Starzl
Journal: JAMA (1987)

During 1986, a total of 270 cadaver renal transplantations were performed at the University of Pittsburgh.Kidneys were allocated by a point system that awarded points to recipients for waiting time, antigen matching, antibody analyses, medical urgency, and logistic practicality.Kidneys were given to patients with the highest paint totals in 98% of cases.To our knowledge, this is the first such multifactorial system for cadaver kidney allocation.Possibly it may be modified for extrarenal organs.
THE RÔLE AND DEVELOPMENT OF DRUG THERAPY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WATER SUPPLY AND PUBLIC HEALTH.
Authors: EDWIN O. JORDAN
Journal: JAMA (1907)

<h3>3. BACTERIAL EXAMINATION.</h3> When sanitarians generally came to recognize that the constituents that impart a dangerous character to polluted water were living organisms belonging to the class of bacteria, it seemed to many a fair inference that by testing for the presence of these bacteria more accurate and direct information could be obtained as to the safety of a water than by testing for chemical substances which were not in themselves injurious. Projects for the bacterial examination of water were consequently entered on with much enthusiasm, but the original expectations excited by this mode of procedure have by no means been realized. It was soon found that the search for specific pathogenic bacteria in water was but rarely crowned with success, and that among the multitude of bacteria present in sewage and polluted water but few could be regarded as dangerous; it is now manifest that for the present the
Symposium on Progress and Perspectives in the Treatment of Gastrointestinal Tumors
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Symposium on Progress and Perspectives in the Treatment of Gastrointestinal Tumors Get access JNCI: Journal of the National Cancer Institute, Volume 64, Issue 3, March 1980, Page 689, https://doi.org/10.1093/jnci/64.3.689-c Published: 01 March 1980
Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases
Authors: A. C. Bianco
Journal: Endocrine Reviews (2002)

The goal of this review is to place the exciting advances that have occurred in our understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3, respectively) iodothyronine deiodinases into a biochemical and physiological context. We review new data regarding the mechanism of selenoprotein synthesis, the molecular and cellular biological properties of the individual deiodinases, including gene structure, mRNA and protein characteristics, tissue distribution, subcellular localization and topology, enzymatic properties, structure-activity relationships, and regulation of synthesis, inactivation, and degradation. These provide the background for a discussion of their role in thyroid physiology in humans and other vertebrates, including evidence that D2 plays a significant role in human plasma T3 production. We discuss the pathological role of D3 overexpression causing "consumptive hypothyroidism" as well as our current understanding of the pathophysiology of iodothyronine deiodination during illness and amiodarone therapy. Finally, we review the new insights from analysis of mice with targeted disruption of the Dio2 gene and overexpression of D2 in the myocardium.
A DISREGARDED SOURCE OF SURGICAL INFECTIONS.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroleptics. Violence as a manifestation of akathisia
Authors: W. A. Keckich
Journal: JAMA (1978)

NEUROLEPTIC medications (eg, phenothiazines, butyrophenones) are used in medicine to control psychotic symptoms and concomitant agitated and violent behavior. They also are used to control anxiety and agitation whenever minor tranquilizers (eg, benzodiazepines) would be inappropriate. Development of akathisia as a parkinsonian side effect is confirmed in the use of these drugs. Akathisia is a condition that gives rise to the subjective desire to be in constant motion, with a feeling of inner agitation and muscle tension. The patient cannot sit still and paces constantly.<sup>1</sup> To my knowledge, however, the literature does not contain reports that the development of akathisia can precipitate violence, resulting in the behavior the drug was meant to alleviate. <h3>Report of a Case</h3> A 29-year-old man had a diagnosis of sociopathic personality and transvestism and a long history of drug abuse, including amphetamines, marijuana, alcohol, LSD, mescaline, benzodiazepines, and narcotics. The patient had a prior
Ohio Varicella Death Is Vaccination Wake-up Call
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Passive sensitization of human airways increases responsiveness to leukotriene C&lt;SUB&gt;4&lt;/SUB&gt;
Authors: D. Schmidt, E. Ruehlmann, D. Branscheid, H. Magnussen, K.F. Rabe
Journal: European Respiratory Journal (1999)

Interleukin (IL)-10 is a potent regulatory cytokine that decreases inflammatory responses. This study investigated whether IL-10 levels in the airway are decreased in chronic airway inflammation associated with asthma or chronic obstructive pulmonary disease (COPD). Sputum was obtained from 12 healthy nonsmokers, 10 healthy smokers, 16 asthmatic patients and seven patients with COPD by means of the sputum-induction method. The IL-10 level was measured via enzyme-linked immunosorbent assay and immunocytochemical analysis. The IL-10 level in sputum was significantly lower in asthma and COPD patients and healthy smokers compared with that in healthy nonsmokers (nonsmokers, 68.0+/-11.3; smokers, 45.3+/-7.8; asthma, 26.7+/-4.0; COPD, 18.0+/-2.3 pg x mL(-1); p&lt;0.05 for nonsmokers versus the other groups). The percentage of IL-10-positive cells in the sputum was also significantly lower in asthma and COPD and in smokers (nonsmokers, 13.2+/-1.7; smokers, 6.4+/-1.8; asthma, 5.4+/-3.5; COPD, 3.5+/-1.6%; p&lt;0.05 for nonsmokers versus the other groups). The IL-10-positive cell appeared morphologically to be the macrophage. These data suggest that the reduced level of interleukin-10 within the airways plays a role in the pathogenesis of chronic airway inflammation in asthma and chronic obstructive pulmonary disease.
The Cover
Authors: —Ann Bartling
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COWPOX AND SMALLPOX
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Bane report revisited
Authors: C. C. Fordham
Journal: JAMA (1980)

SPEAKING at the annual meeting of the Association of American Medical Colleges in October 1978, former Secretary of the then US Department of Health, Education, and Welfare (DHEW), Joseph Califano, Jr, acknowledged that the nation may soon face an aggregate oversupply of physicians.<sup>1</sup>This view is shared by many persons and resisted by others, but it undeniably expresses a continuing dilemma in public and health policy in this country. There has been remarkable expansion of the medical educational capacity of this country during the past two decades. Expansion continues, and with the declining rate of population growth, many knowledgeable people now project an excess aggregate physician supply. Yet, there are many underserved communities, especially in rural areas and inner cities; the geographic maldistribution and the perception of a public preference for more generalist physicians continue to fuel expansion of medical education. The federal government has played a significant role
Characteristics of ischemic myocardium detected by positron emission tomography during left ventricular electromechanical mapping Khaled A. Nour, Shmuel Fuchs, Julian P.J. Halcox, Ran Kornowski, Rita Mincemoyer, Claiborne Miller-Davis, Vasken Dilsizian, Arshed A. Quyyumi. Cardiology Branch, National Institutes of Health, Bethesda, MD
Journal: Journal of the American College of Cardiology (2001)
AN ADVANCE IN PSYCHO-PATHOLOGIC STUDY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiothoracic Surgery
Authors: Floyd D. Loop
Journal: JAMA (1985)

Mortality rates from lung cancer in women have exceeded those from breast cancer. In some states, lung cancer is already the most important single cause of death from cancer in women. Among male cigarette smokers studied at Memorial Sloan-Kettering, early screening for lung cancer yielded a higher complete resectability rate than later diagnosis after symptoms occurred. Earlier diagnosis resulted in a five-year survival of 35%, an 8% to 9% improvement over survival of nonscreened men.<sup>1</sup> Treatment for non—small-cell lung cancer is contingent on TNM staging. Apparently, none of the noninvasive staging procedures singly or collectively is sensitive enough to replace totally mediastinoscopy for accurate preoperative staging of lung cancer. The value of magnetic resonance imaging has yet to be defined. Whereas T3 tumors exclusive of those invading the chest wall have a reasonable chance of cure with radical resection, associated N2 disease yields a much poorer prognosis.<sup>2</sup>Of