tbuckley/cabot-search huggingface dataset:
Retraction Note: Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/β-catenin signaling pathway
Authors: Ze-you Wang, Min Hu, Min-hui Dai, Jing Xiong, Shuai Zhang, Han-jiang Wu, Shan-shan Zhang, Zhao-jian Gong
Journal: Molecular Cancer (2019)

The authors have retracted this article [1] because there are errors in Figures 4a and 4b.
FAT AND THE DIABETIC PATIENT
Journal: JAMA (1934)

Conventionally, diabetes is considered a disease involving, primarily, carbohydrate metabolism. The striking effect of insulin on the concentration of blood sugar has served to confirm the association. Nevertheless, the disturbance of fat metabolism plays no small part in the pathogenesis of this disease. In a recent review, Joslin<sup>1</sup>has summarized various aspects of the significance of fat to the diabetic patient. He repeatedly points out the great change brought about in the outlook for the diabetic child by the introduction of insulin. Among the results of the prolongation of life of this younger group of patients is the realization not only that heredity plays an important part in the predisposition to the disease but also that obesity alone is probably a less significant factor than was formerly believed; it merits special attention when there is a hereditary tendency. Although the obese person may show a decreased pancreatic efficiency, the
Antineoplastic Urinary Protein Inhibits Kaposi’s Sarcoma and Angiogenesis In Vitro and In Vivo
Authors: Rizwan Masood, Megan E. McGarvey, Tong Zheng, Jie Cai, Naveen Arora, D. Lynne Smith, Nathan Sloane, Parkash S. Gill
Journal: Blood (1999)
Cumulative risk adjusted mortality chart for detecting changes in death rate: observational study of heart surgery
Journal: BMJ (1998)

Objective: To detect changes in mortality after surgery, with allowance being made for variations in case mix.Design: Observational study of postoperative mortality from January 1992 to August 1995.Setting: Regional cardiothoracic unit.Subjects: 3983 patients aged 16 and over who had open heart operations.Main outcome measures: Preoperative risk factors and postoperative mortality in hospital within 30 days were recorded for all surgical heart operations.Mortality was adjusted for case mix using a preoperative estimate of risk based on additive Parsonnet factors.The number of operations required for statistical power to detect a doubling of mortality was examined, and control limits at a nominal significance level of P = 0.01 for detection of an adverse trend were determined.Results: Total mortality of 7.0% was 26% below the Parsonnet predictor (P < 0.0001).There was a highly significant variation in annual case mix (Parsonnet scores 8.7-10.6,P < 0.0001).There was no significant variation in mortality after adjustment for case mix (odds ratio 1-1.5, P = 0.18) with monitoring by calendar year.With continuous monitoring, however, nominal 99% control limits based on 16 expected deaths were crossed on two occasions.Conclusions: Hospital league tables for mortality from heart surgery will be of limited value because year to year differences in death rate can be large (odds ratio 1.5) even when the underlying risk or case mix does not change.Statistical quality control of a single series with adjustment for case mix is the only way to take into account recent performance when informing a patient of the risk of surgery at a particular hospital.If there is an increase in the number of deaths the chances of the next patient surviving surgery can be calculated from the last 16 deaths.
GENE-57. COMPARATIVE MOLECULAR LIFE HISTORY OF SPONTANEOUS CANINE AND HUMAN GLIOMA
Authors: Samirkumar Amin, Kevin Anderson, Beth Bourdreau, Emmanuel Martínez, Emre Kocakavuk, Kevin C Johnson, Floris Barthel, Frederick Varn, Cynthia Kassab, Xiaoyang Ling, Hoon Kim, Mary Barther, Chew Yee Ngan, Peter Dickinson, Rebecca Packer, Amanda Taylor, John Rossmeisl, Amy Heimberger, Jonathan Levine, Roel Verhaak
Journal: Neuro-Oncology (2019)

Abstract Diffuse gliomas are the commonest of malignant brain tumors with high-grade tumors carrying dismal prognosis. Preclinical models have proven themselves as poor predictors of clinical efficacy, attributed to the lack of a comparable tumor microenvironment. Comparative genomics of canine and human gliomas provide an attractive alternative modality to identify conserved drivers and underlying mutational processes of glioma as well as evaluate life history tradeoffs related to tissue context and aging that can shape type and relative timing of drivers in gliomagenesis. We performed a comparative genomics analysis between whole genome-, exome-, transcriptome- and methylation-sequencing of 77 canine gliomas, and human pediatric (n=217) and adult gliomas (n=822). We found alterations in common with those in human pediatric and adult gliomas in the Tp53 and cell cycle pathways, receptor tyrosine kinase and Idh1 R132 mutations. Canine gliomas showed similarity to human pediatric gliomas in terms of lower mutational rates (0.2–0.29 per megabase), hotspot mutations and amplifications of Pdgfrα, and robust aneuploidy constrained within the syntenic regions of Pdgfrα and Myc, but also in the known pediatric drivers, Hist1 and Acvr1 genes. A mutational signature reflecting homologous repair defect was detected in canine and pediatric but not adult gliomas, potentially resulting in the observed higher rates of genomic instability. Canine gliomas in majority classified as pediatric tumors using a commonly used human brain methylation classifier (Capper et al. 2018) and cell-of-origin analysis by deconvoluting canine transcriptome using lineage-specific gene signatures. By providing a large canine glioma genomic-sequencing dataset and comparing it with human glioma, our study provides unique insights into glioma etiology and the chronology of glioma-causing somatic alterations. Further, our results effectively position preclinical models of spontaneous canine glioma for use in understanding glioma drivers, and evaluate novel therapies targeting aneuploidy, especially for pediatric brain tumors.
Destructive lesion of the proximal radius
Authors: K. T. Benedict
Journal: JAMA (1970)

Dr. Spencer BordenIV: The patient is a 63-year-old woman, a housewife, who had been in excellent health until she fell on her left wrist 17 months prior to admission here. Roentgenograms taken at that time were said to be normal. Since then she has noted intermittent aching in the wrist and distal forearm with heavy use. The aching has increased over the past two months. Additional roentgenograms were abnormal (Figure), and she was admitted for further observation. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Weiner, would you discuss this case, please? Dr. Milton A. Weiner: There is an obvious destructive lesion in the proximal shaft of the radius. It also involves the radial head which is fractured. The lesion has irregularly eroded the cortex and produced a slight, nonhomogeneous periosteal reaction laterally. The bone is minimally expanded along its volar aspect, but I see no soft-tissue mass or joint effusion.
Actual Causes of Death in the United States
Authors: Don E. Detmer
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The recent article by Drs McGinnis and Foege<sup>1</sup>identifies and quantifies major nongenetic factors that contribute to death in the United States. They found that 50% of all deaths in 1990 were attributable to tobacco, diet and activity patterns, alcohol, microbial agents, toxic agents, firearms, sexual behavior, motor vehicles, and illicit drug use. McGinnis and Foege then note the significance of these findings for health policy priorities. We wholeheartedly applaud their effort and wish to propose and encourage the development of an etiologically based classification of diseases as a supplement to our current mélange known as the International Classification of Diseases. We have been involved in similar research aimed at estimating the contribution of social and behavioral factors to mortality and believe there is great benefit to a cause of death classification system that reflects true etiology. At present, we classify disease using a potpourri of discordant
New Women's Health Resource
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NCI Study to Assess Clinical Alert Impact
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article NCI Study to Assess Clinical Alert Impact Get access JNCI: Journal of the National Cancer Institute, Volume 80, Issue 11, 3 August 1988, Pages 794–795, https://doi.org/10.1093/jnci/80.11.794-a Published: 03 August 1988
The IOM report and public health. Council on Scientific Affairs
Journal: JAMA (1990)

A recent Institute of Medicine report defined "public health" as what society must do to keep people healthy and further defined it as involving the collection of data, assessment of problems, and assurance of health protection. Public health professionals include physicians, nurses, sanitarians, biostatisticians, engineers, and administrators, and epidemiology is public health's basic science. Past successes in the United States, such as increases in longevity and decreases in infant mortality and cardiovascular death rates, demonstrate that progress is possible; however, inequalities persist, for example, in infant mortality rates and availability of medical care to lower socioeconomic groups. The major responsibilities of public health departments include leading and coordinating public health efforts, controlling epidemics, carrying out disease and injury surveillance, collecting vital statistics, ensuring good medical and dental care for the indigent, environmental control, health education, and laboratory services.
In Reply
Authors: Antonino Musolino, Nadia Naldi, Beatrice Bortesi, Debora Pezzuolo, Marzia Capelletti, Gabriele Missale, Diletta Laccabue, Alessandro Zerbini, Roberta Camisa, Giancarlo Bisagni, Tauro Maria Neri, Andrea Ardizzoni
Journal: Journal of Clinical Oncology (2008)
Every Day Is Fish Day
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUMMARIOS IN INTERLINGUA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combination of the mTOR Inhibitor Rapamycin and Revlimid™ (CC-5013) Has Synergistic Activity in Multiple Myeloma (MM).
Authors: Noopur Raje, Shaji Kumar, Teru Hideshima, Kenji Ishitsuka, Dharminder Chauhan, Constantine Mitsiades, Klaus Podar, Steven Le Gouill, Paul Richardson, Nikhil C. Munshi, David I. Stirling, Joseph H. Antin, Kenneth C. Anderson
Journal: Blood (2004)
Hepatitis B virus core protein variants observed in a first-in-human placebo-controlled study of a core protein inhibitor
Authors: Amy C.H. Lee, Emily P. Thi, Andrzej Ardzinski, Joanne Brown, Timothy Eley, Nagraj Mani, Rene Rijnbrand, Karen Sims, Michael J. Sofia, Gaston Picchio
Journal: Journal of Hepatology (2020)
Task Force 3: Disclosure of Relationships With Commercial Interests: Policy for Educational Activities and Publications
Authors: Alice K. Jacobs, Bruce D. Lindsay, Bruce J. Bellande, Gregg C. Fonarow, Rick A. Nishimura, Pravin M. Shah, Brian H. Annex, Valentin Fuster, Raymond J. Gibbons, Marcia J. Jackson, Shahbudin H. Rahimtoola
Journal: Circulation (2004)
Editorial: Estrogens and the menopause
Authors: N. Kase
Journal: JAMA (1974)

The climacteric woman faces a variety of clinical problems that are thought to be associated with the decline in estrogen production and function that follows the menopause. These include osteoporosis, arteriosclerosis, mucous membrane deterioration, disorders of the skin and genitourinary system, as well as psychological difficulties. When one considers that at the time of the 1970 census, of the 104 million women in the United States 27 million were 50 years old or more—and each woman at age 50 has an expectation of living an additional 28 years—the magnitude of the public health challenge that the menopause presents can be appreciated. In reaction to this challenge and despite the fact that the mechanisms by which the disorders of aging relate (if at all) to waning estrogen are either unknown, uncertain, or disputed, the use of empiric estrogen "replacement" therapy has been advocated to relieve or retard some or all of
THE VISITS OF THE CLERGYMAN TO OUR PATIENTS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The impact on patient management of whole-body FDG-PET scanning in patients with liver metastases from colorectal carcinoma
Authors: T. W. Bauer, S. A. Curley, H. A. Macapinlac, M. A. Rodriguez-Bigas, C. Eng, E. H. Lin, J. N. Vauthey, L. M. Ellis, J. M. Skibber, B. W. Feig
Journal: Journal of Clinical Oncology (2004)

3569 Background: The accuracy and utility of FDG-PET (PET) scanning in patients with colorectal carcinoma metastatic to the liver was evaluated. Methods: Whole-body PET scans performed on 100 consecutive patients with liver metastases from colorectal carcinoma between July 2001 and January 2003 were reviewed and correlated with spiral triple-phase computed tomography (CT), serum carcinoembryonic antigen (CEA) level, and final histopathologic diagnosis. Results: The indication for PET was a rise in CEA in 19% of patients, surveillance or restaging in 37%, to exclude additional disease prior to metastasectomy in 33%, or to evaluate "indeterminate" findings on CT in 11%. The sensitivity, specificity, and accuracy of CT were 81%, 100%, and 84%, respectively. The sensitivity, specificity, and accuracy of PET were 84%, 89%, and 85%, respectively. The PET false-positive (FP) rate was 2%: liver & wound (1), mediastinum (1). Sixteen false-negative (FN) sites were observed in 13% of PET scans: liver (5), lung (5), porta hepatis lymph node (2), abdomen/pelvis (4). Two patients underwent unnecessary laparotomy based on FN PET results, whereas CT correctly suggested extrahepatic disease in these two. There was no difference in CEA level between the PET true-positive (TP) and FN groups. In the six cases where CT was "indeterminate," PET correctly diagnosed patients. PET directly altered patient management in 23% of cases and this was independent of PET indication. PET detected liver metastasis not seen on CT in 8%, confirmed liver metastasis read as "indeterminate" on CT in 2%, detected extrahepatic metastasis not seen on CT in 6%, detected metabolic response in metastasis which led to a change in management in 4%, and excluded disease read as "indeterminate" on CT in 2%. When PET was combined with CT, the overall sensitivity, specificity, and accuracy of diagnosis were 96%*, 88%*, and 95%*, respectively (*p<0.05 vs CT alone). Conclusions: PET, when used selectively in patients with liver metastases from colorectal carcinoma, marginally improved the accuracy of diagnosis but directly altered management in 23% of patients. No significant financial relationships to disclose.
Caring for the poor. Council on Ethical and Judicial Affairs, American Medical Association
Authors: Oscar W. Clarke, John Glasson, Allison M. August, Charles H. Epps, Victoria N. Ruff, Craig H. Kliger, Charles W. Plows, George T. Wilkins, James H. Cosgriff, Kirk B. Johnson, David Orentlicher, Robert B. Conley
Journal: JAMA (1993)

DESPITE the fact that the United States is one of the most affluent countries in the world, a significant portion of its citizens have inadequate access to medical care.<sup>1,2</sup>While the barriers to obtaining health care are numerous, perhaps the most difficult hurdle to overcome is the lack of financial resources to pay for it. Although there appears to be a growing consensus that all people should receive basic health care, there is little agreement on how to achieve or finance this goal or even how to define it.<sup>3</sup> This report examines the individual medical practitioner's ethical obligation to treat the poor. Because much of the recent attention has focused on broader societal obligations and systematic reform, the role of the individual has been overshadowed. The American Medical Association (AMA) has long recognized an ethical obligation of physicians to assume some individual responsibility for making health care available
MICROPSIA
Authors: JEROME M. SCHNECK
Journal: American Journal of Psychiatry (1961)

Micropsia may accompany neurological defect or dysfunction as in tumors of the temporal lobe and petit mal. It may be encountered as a psychopathological phenomenon without structural defect. It is described relatively infrequently in medical literature. The symptom involves seeing objects or people as very small, off in the distance, as if one were looking "through the wrong end of a telescope."An impression of objects moving away, into the distance, is often described. A patient in psychiatric treatment told of a series of such episodes during his childhood. His micropsia apparently reflected his expansive needs counteracting a closed-in feeling, his reaction to heavy psychological pressures, an attempt to cope with intense repressed anger, a way of symbolically manipulating people identified as objects, and a method of exercising control to cope with feelings of weakness and insecurity. The micropsia was a mirror of his feeling of separation from people and things about him during those childhood years, and it serves as an indication of his loneliness. It was a sign of diminishing ego strength, but was not followed by a psychotic break. Defenses were evidently reinforced later, judging by the patient's history and the personality patterns that evolved. The oral and aggressive components in this case were witnessed by others in studies of their patients. Pertinent references are mentioned here, and the observations integrated with my own findings. Similarities and differences in the cases are noted. Finally, mention is made briefly of another patient of mine with micropsia although there was no opportunity to evaluate the psychodynamics of his problem.
Commentaire de travail de J. M. Buscaglia et al., pp. 194
Journal: Endoscopy (2009)

See also: The spiral enteroscopy training initiative: results of a prospective study evaluating the Discovery SB overtube device during small bowel enteroscopy (with video)Endoscopy 2009; 41(03): 194-199DOI: 10.1055/s-0028-1119602