tbuckley/cabot-search huggingface dataset:
MedComm
Journal: MedComm (2020)

Graphical Abstract In the Omicron wave, two emerging subvariants, BQ.1 and XBB, have rapidly become a global public health concern. This diagram illustrates the critical spike mutations in these subvariants, which can lead to immune escape from prior COVID-19 vaccines, boosters, and therapeutic monoclonal antibodies (mAbs). Notably, XBB.1.5, which carries a rare F486P mutation, has demonstrated significantly higher receptor-binding domain (RBD)-ACE2 binding affinity and transmissibility compared to other subvariants, making it the dominant strain in several countries.
Loss of p27Kip1 enhances the transplantation efficiency of hepatocytes transferred into diseased livers
Authors: Anthony N. Karnezis, Marina Dorokhov, Markus Grompe, Liang Zhu
Journal: Journal of Clinical Investigation (2001)

p27Kip1 is an important regulator of cyclin-dependent kinases. Studies with p27 knockout mice have revealed abnormalities in proliferation and differentiation of multiple cell types. Here we show that primary hepatocytes isolated from livers of adult p27 knockout mice exhibit higher levels of DNA synthesis activity in culture than do wild-type cells. Interestingly, we found that, compared with control hepatocytes, p27 knockout hepatocytes proliferate better after transplantation into diseased livers to reverse liver failure. These results reveal an aspect of p27 that could be used to benefit cell-based therapy.
Impact of multidisciplinary management in the diagnosis and treatment of neuroendocrine tumors.
Authors: Anuradha Krishnamurthy, Reed Weiss, Lia Head, Cheryl Lauren Meguid, Sarah Lindsey Davis, Steven Arthur Ahrendt, Wells A. Messersmith, William T. Purcell, Alexis Diane Leal, Karyn A. Goodman, Thor Johnson, Matthew Brown, Megan Boniface, Whitney Herter, Barish H. Edil, Richard D. Schulick, Martin McCarter, Stephen Leong, Christopher Hanyoung Lieu
Journal: Journal of Clinical Oncology (2018)

e16165 Background: The incidence and prevalence of NETs is increasing. The complexity of management of NETs has also increased with new advances in local and systemic therapies. Multidisciplinary management models have been suggested in guidelines based on extrapolated data from other disease sites and expert opinion. However, scientific data showing definite change in management with multidisciplinary review is lacking. Methods: Seventy-two patients with metastatic NET to the liver from 2012-17 from a dedicated multidisciplinary clinic (MDC) where patients are seen simultaneously by multiple subspecialties were reviewed, and data on patient characteristics, radiology, tumor pathology and treatment strategies were collected. Change in diagnosis was defined as any change in radiographic or pathologic findings that resulted in a change in the site, stage, or grade of cancer. Treatment strategies recommended/employed prior to MDC were compared with recommendations given at MDC to determine if there was a change in management. Results: The mean age of patients evaluated was 61, with locally advanced or metastatic disease seen in 90% of patients. Small bowel and pancreatic NETs were the most common primaries, and a significant proportion of NETs were well differentiated (88%) with a low mitotic index (65%) and Ki-67 (52%). Patients were referred to MDC at 2.9 years from diagnosis and 11% of patients had received liver directed therapies (LDTs) at time of referral. Half the patients had resection of primary while 31% had received somatostatin analogues previously. There were changes to tumor type (4%), stage (5.6%), grade (1.5%), and site of disease (7%) post MDC evaluation. Change in management was recommended in 62% of patients. LDTs were recommended more frequently (26%) with radioembolization being the most common therapy of choice. Recommendation for somatostatin analogue use was made in 43% of patients. Multiple treatment options were provided by the MDC in 45% of cases. Conclusions: The use of a dedicated MDC to manage metastatic NET has a substantial impact in change in diagnosis and/or management in a significant percentage of patients evaluated.
Use of a chemotherapy toxicity prediction tool to decrease the risks for hospitalization in the elderly.
Authors: Mintcho Elinov Mintchev, Adrian Reyes Bersabe
Journal: Journal of Clinical Oncology (2018)

e22047 Background: Oncologists commonly use performance status scores such as ECOG and Karnofsky when making treatment decisions. However, there is limited data on the utility of these measures in selecting therapy and predicting treatment-related complications in the elderly. In July 2016, medical oncologists at our institution made it standard practice to use the Cancer and Aging Research Group toxicity prediction score (CARG) to identify elderly patients who are “fit” for conventional therapy versus those who are “frail” and may experience increased complications. Methods: We retrospectively reviewed referrals to our outpatient medical oncology clinic for patients 75 years of age and older. Referrals leading to systemic therapy (i.e. chemotherapy, targeted therapy, and immunotherapy) or changes to therapy based on CARG were included in our study. We evaluated CARG utilization during the 6 months before and the 6 months after its institution. We also assessed how changes to therapy due to CARG impacted admissions and emergency department (ED) visits. Results: Thirty-eight patients with mean age of 81.2 years, 52.6% male, met inclusion criteria. Their diagnoses included GI (36.8%), lung (21.1%), hematologic (18.4%), breast (10.5%), GU (2.6%), and other (10.5%) malignancies. During 2016, CARG was assessed in 14 patients, 9 of whom received systemic therapy. CARG was assessed in 12.5% and 41.2% of patients receiving systemic therapy in the 6-month periods before and after its incorporation, respectively. There were fewer mean admissions (0.7 versus 2.25), days of admission (4.3 versus 8), and ED visits (1.1 versus 2.5) when therapy was decreased in intensity or withheld based on CARG. However, the study lacked power to establish statistical significance. Conclusions: A CARG assessment occurred in less than 50% of elderly cancer patients who received systemic therapy. Therapy modifications based on CARG may lead to fewer hospitalizations and ED visits, but more consistent use of the score and further investigation are necessary.
Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in a Greek population of blood donors
Authors: T Antoniadi, T Hatzis, C Kroupis, E Economou-Petersen, M B Petersen
Journal: American Journal of Hematology (1999)

The pathogenesis of venous thrombosis involves the interaction of genetic and environmental factors. In order to estimate the frequency of the factor V Leiden, the prothrombin G20210A, and the MTHFR C677T mutations in the Greek population, we analyzed 160 healthy Greek blood donors by PCR amplification and detected allele frequencies of 2.5%, 2.2%, and 35.3%, respectively. The allele frequencies were compared with reported frequencies of other populations of southern Europe. The identification of these common genetic risk factors for thrombosis should enable easy DNA diagnosis and carrier detection in a high proportion of cases and will contribute to a better understanding of the interaction of genetic and environmental risk factors.
Assisted Computed Tomography Aids Diagnoses of Two Cancers
Authors: M. Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ATLANTIC CITY MEETING
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatrics Update
Authors: Jody Zylke
Journal: JAMA (1987)

For the busy practitioner who needs a summary of recent developments or the specialist who wants to keep up with other areas of the field, there are a multitude of review books and articles.<i>Pediatrics Update</i>is one such book, published annually since 1979. This year's volume contains 19 chapters, each written by authorities in the specific subject area. A wide variety of topics are covered, but no attempt is made to include all specialties. Hematology-oncology, for example, is not represented in this edition, perhaps because it was included in last year's text. Neurology and gastroenterology, on the other hand, constitute almost 40% of the book. Since an update, by its very nature, is aimed at a wide audience, a certain minimal amount of information on each subject should be provided, and each subject should be critically examined. The primary objective of each chapter may be different, either to review
794 EFFICACY OF RIBAVIRIN PLUS PEGINTERFERON-ALFA IN ELDERLY PATIENTS WITH CHRONIC HEPATITIS C
Authors: T. Honda, Y. Katano, M. Doizaki, K. Hayashi, M. Ishigami, I. Nakano, F. Urano, K. Yoshioka, H. Toyoda, T. Kumada, H. Goto
Journal: Journal of Hepatology (2008)
Manuscripts Approved for JNCI, December 1972–January 1973
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Manuscripts Approved for JNCI, December 1972–January 1973 Get access JNCI: Journal of the National Cancer Institute, Volume 50, Issue 2, February 1973, Page 581, https://doi.org/10.1093/jnci/50.2.581 Published: 01 February 1973
In Vitro Assay of Cytotoxicity with Cultured Liver: Accomplishments and Possibilities
Authors: Joe W. Grisham, Ronald K. Charlton, David G. Kaufman
Journal: Environmental Health Perspectives (1978)

Tissue cultures offer potential advantages for assaying the toxicity of chemicals and for evaluating tissue susceptibility to toxic agents. Several properties of cultured cells hinder the immediate, widespread use of tissue cultures to assay toxicity routinely. These points are illustrated by briefly reviewing attempts to utilize different types of hepatic cultures to evaluate the actions of carcinogenic chemicals in vitro. Hepatocytes in vivo apparently can metabolize all known procarcinogenic chemicals, but the process of tissue isolation and the environmental conditions in vitro may modify drastically the responses of hepatocytes and other cultured hepatic cells to toxic chemicals. Before cell cultures can be used routinely as the basis of screening systems to detect chemical toxins, specificity and sensitivity of response to chemicals representing all chemical classes must be validated by laboratory studies.
Continuous versus Intermittent Nebulized Terbutaline: Plasma Levels and Effects
Authors: Frank W. Moler, Cary E. Johnson, Craig van Laanen, John M. Palmisano, Samya Z. Nasr, Olugbenga Akingbola
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The purpose of this investigation was to compare continuous versus intermittent nebulization of a β-agonist, terbutaline, to determine whether differences exist in plasma concentrations or adverse cardiovascular effects of the drug with these two techniques for its administration. Sixteen children 6 to 16 yr of age, admitted for acute asthma, were enrolled in this randomized double-blind clinical trial. Nebulization of 16 mg of terbutaline over an 8-h period was performed either continuously or intermittently, with a dose of 4 mg given over 20 min every 2 h. The peak plasma terbutaline concentration for the intermittent nebulization treatment (INT) group (5.1 ± 2.1 ng/ml) occurred 1 h after the fourth inhalation treatment and was similar to the peak concentration for the continuous nebulization treatment (CNT) group, which was reached at the end of the 8 h period (4.7 ± 2.3 ng/ml). The maximum heart rate increase for the INT group (19.6 ± 18.3 bpm) occurred 1 h after the fourth dose and was similar to the peak observed in the CNT group (19.6 ± 19.2 bpm), which occurred after 3 h. Similar increases in systolic and decreases in diastolic pressures were observed for the INT and CNT groups. No evidence of serious adverse myocardial complications was seen in either group, as evidenced by measurements of the MB fraction of creatine phosphokinase (CPK-MB) and Holter-monitor recordings. Continuous nebulization of the terbutaline produces similar plasma concentrations and cardiovascular physiologic responses as intermittent nebulization. These findings suggest that the improved therapeutic efficacy of frequent or continuous β-agonist administration is not secondary to a greater systemic drug concentration achieved with this technique but rather to more optimal direct local pulmonary effects.
A Cover Without Art
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PELLAGRA
Authors: J. D. LONG
Journal: JAMA (1910)

While engaged in the study of 130 cases of amebiasis (amebic dysentery) during portions of 1907, 1908 and 1909, at the Marine Hospital in San Francisco, it was noted that the majority of the patients showed symptoms of secondary complications. Some complained of rheumatic pains and neuralgias; others complained of headache and indigestion and became constipated at times; others showed lesions on the hands, feet and legs which were thought to be trophic in character and which were usually in the form of dryness of the skin, or in the form of small pinhead-sized vesicles, which tended to coalesce and later to form bullæ. There was also more or less marked interference with the mobility of the various joints and of the spine. In searching for the cause of these symptoms the<i>x</i>-ray demonstrated that the rheumatic pains, neuralgias, etc., were apparently caused by the presence of some sort
Environmental Effects and Aquatic Organisms: Investigations of Molecular Mechanisms of Carcinogenesis
Authors: Rebecca J. Van Beneden
Journal: Environmental Health Perspectives (1997)

Cancers of the reproductive system are among the leading causes of mortality in women in the United States.While both genetic and environmental factors have been implicated in their etiology, the extent of the contribution of environmental factors to human diseases remains controversial.To better address the role of environmental exposures in cancer etiology, there has been an increasing focus on the development of nontraditional, environmentally relevant models.Our research involves the development of one such model.Gonadal tumors have been described in the softshell clam (Mya arenaria) in Maine and the hardshell clam (Mercenaria spp.) from Florida.Prevalence of these tumors is as high as 40% in some populations in eastern Maine and 60% in some areas along the Indian River in Florida.The average tumor prevalence in Maine and Florida is approximately 20 and 11 %, respectively.An association has been suggested between the use of herbicides and the incidence of gonadal tumors in the softshell clam in Maine.The role of environmental exposures in the development of the tumors in Mercenaria in Florida is unknown; however, there is evidence that genetic factors may contribute to its etiology.Epidemiologic studies of human populations in these same areas show a higher than average mortality rate due to cancers of the reproductive system in women, including both ovarian and breast cancer.The relationship, if any, among these observations is unknown.Our studies on the molecular basis of this disease in clams may provide additional information on environmental exposures and their possible link to cancer in clams and other organisms, including humans.Environ Health Perspect 1 05(Suppl 3):669-674 (1997) Key words: comparative carcinogenesis, gonadal tumor, Ah receptor, dioxin, bivalves, TCDD, nontraditional models the molecular basis of cell growth, cell death and differentiation, and how the deregulation of these normal processes con- tributes to cell transformation.In 1996, the annual appropriation for the National Cancer Institute was $2.25 billion, a significant increase from the $200 million allotted in 1971 at the inception of the program.Yet, in spite of the great strides we have achieved in basic research, approximately 40% of Americans will develop cancer in
MONUMENTS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vitreous
Authors: Jen Karetnick
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impressions of group practices. Future outlook hopeful?--Guildford.
Journal: BMJ (1965)

AThe practice at Edinburgh (27 November, p. 1300) showed- )4hw unwise are any generalizations about group practice.evertheless, if one theme has been uppermost, both in the ~CV nt correspondence in the B.M.Y. and in my visits to health U:entes and group practices, it is the apparent virtual imposfility of erecting new, purpose-built premises at the present thiie.It was thus surprising, and heartening, to hear of the Kiitative of some doctors in Guildford who are spending t5,000 on a new group-practice centre.Moreover, this Scheme itself was the outlome of ten years' hard planning by e partes and a professional work-study of the practice >t~o years ago.
ESTABLISHING THE TIME OF UNWITNESSED DEATH
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal