High-Dosage Vitamin E Supplementation and All-Cause Mortality
Authors: Connie Marras, Anthony E. Lang, David Oakes, Michael P. McDermott, Karl Kieburtz, Ira Shoulson, Caroline M. Tanner, Stanley Fahn
Journal: Annals of Internal Medicine (2005)

Letters19 July 2005High-Dosage Vitamin E Supplementation and All-Cause MortalityConnie Marras, MD, Anthony E. Lang, MD, David Oakes, PhD, Michael P. McDermott, PhD, Karl Kieburtz, MD, MPH, Ira Shoulson, MD, Caroline M. Tanner, MD, PhD, and Stanley Fahn, MDConnie Marras, MDFrom the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032., Anthony E. Lang, MDFrom the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032., David Oakes, PhDFrom the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032., Michael P. McDermott, PhDFrom the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032., Karl Kieburtz, MD, MPHFrom the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032., Ira Shoulson, MDFrom the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032., Caroline M. Tanner, MD, PhDFrom the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032., and Stanley Fahn, MDFrom the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-2-200507190-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In a meta-analysis of selected randomized trials, Miller and colleagues (1) found an increase in all-cause mortality associated with high-dosage vitamin E supplementation for at least 1 year (1). Their analysis included the DATATOP study, a randomized, placebo-controlled trial of selegiline and vitamin E in 800 patients with early Parkinson disease (2). In the DATATOP trial, 399 of 800 participants were randomly assigned to receive 2000 IU of vitamin E per day, the highest dosage studied in Miller and colleagues' meta-analysis. Median duration of vitamin E exposure during the randomized phase was 2.6 years. We have now ...References1. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46. [PMID: 15537682] LinkGoogle Scholar2. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. The Parkinson Study Group. N Engl J Med. 1993;328:176-83. [PMID: 8417384] CrossrefMedlineGoogle Scholar3. Marras C, McDermott MP, Rochon PA, Tanner CM, Naglie G, Rudolph A, et al. Survival in Parkinson disease: thirteen-year follow-up of the DATATOP cohort. Neurology. 2005;64:87-93. [PMID: 15642909] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of Toronto, Toronto, Ontario MST 258, Canada; University of Rochester Medical Center, Rochester, NY 14642; The Parkinson's Institute, Sunnyvale, CA 94809-1605; and Columbia University, New York, NY 10032.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality Edgar R. Miller III , Roberto Pastor-Barriuso , Darshan Dalal , Rudolph A. Riemersma , Lawrence J. Appel , and Eliseo Guallar High-Dosage Vitamin E Supplementation and All-Cause Mortality Simin Nikbin Meydani , Joseph Lau , Gerard E. Dallal , and Mohsen Meydani High-Dosage Vitamin E Supplementation and All-Cause Mortality Kent J. 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Morris Metrics Cited byVitamin E and Mortality: A Critical Perspective of the Conflicting Meta-analysis OutcomesNutrient plasma levels achieved during treatment that reduces noise-induced hearing lossBioactive Nutritional Supplements for Chronic Kidney Disease: Potential Cost BenefitsDecision Analysis Supports the Paradigm That Indiscriminate Supplementation of Vitamin E Does More Harm than GoodAdverse effects of vitamin E by induction of drug metabolismCellular, molecular and clinical aspects of vitamin E on atherosclerosis preventionVitamin E Regulatory MechanismsThe Roles of α‐Vitamin E and Its Analogues in Prostate CancerAntioxidant vitamins supplementation and mortality: A randomized trial in head and neck cancer patients 19 July 2005Volume 143, Issue 2Page: 152-153KeywordsConflicts of interestParkinson diseaseVitamin E ePublished: 19 July 2005 Issue Published: 19 July 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. 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