tbuckley/cabot-search huggingface dataset:
RIO DE JANEIRO
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2464: Increase in N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide after Eurotransplant Urgency Listing as a Measure for Predicting Outcome after Heart Transplantation
Authors: Takeshi Komoda, Hans B Lehmkuhl, Christoph Knosalla, Evgenij Potapov, Michael Dandel, Onnen Grauhan, Roland Hetzer
Journal: Circulation (2007)

Background When candidates for heart transplantation (HTx) show high levels of N-terminal brain-type natriuretic peptide (NT-proBNP), the prognosis of the patients is poor. However, identification of these high-risk patients is a matter for discussion. We investigated increase of NT-proBNP after listing with Eurotransplant for urgent HTx as a measure to predict outcome after HTx. Methods Plasma NT-proBNP was measured in 59 HTx candidates without mechanical circulatory support before and after urgency listing. Complications and mortality after HTx in relation to changes in plasma NT-proBNP levels before and after urgency listing were studied. Percentile increases of maximal NT-proBNP values after urgency listing were compared with values prior to urgency listing and defined as delta-max NT-proBNP. Results Area under the receiver operating characteristic (ROC) curve of delta-max NT-proBNP predicting mortality was 0.67. When the cut-off value for delta-max NT-proBNP was determined as 20%, 16 patients were in the group of increase in max NT-proBNP after urgency listing (Group INC) and the rest were in Group NON (n=43). Thirty-day mortality rate after HTx in Group INC was 37.5 % compared to 14.0 % in Group NON. Actuarial survival in Group INC was significantly worse than in the total of 180 patients who underwent HTx between 2004 and 2006 (p &lt; 0.05, log-rank test). Incidence of infection was significantly higher (p &lt; 0.001, Fisher’s exact probability test) in Group INC (68.8 %) than in Group NON (16.3 %). Long-term mechanical respiratory support (longer than 4 days) was more frequent (p &lt; 0.05) in Group INC (87.5%) than in Group NON (55.8 %). Conclusions Patients with an increase of NT-proBNP of greater than 20% during urgency listing are at higher risk for post-HTx mortality and complications. VAD implantation may be a valid approach in these patients, but this needs to be addressed in future studies.
STATE MEDICINE.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Future Trends Which Will Influence Waste Disposal
Authors: Abel Wolman
Journal: Environmental Health Perspectives (1978)

The disposal and management of solid wastes are ancient problems. The evolution of practices naturally changed as populations grew and sites for disposal became less acceptable. The central search was for easy disposal at minimum costs. The methods changed from indiscriminate dumping to sanitary landfill, feeding to swine, reduction, incineration, and various forms of re-use and recycling. Virtually all procedures have disabilities and rising costs. Many methods once abandoned are being rediscovered. Promises for so-called innovations outstrip accomplishments. Markets for salvage vary widely or disappear completely. The search for conserving materials and energy at minimum cost must go on forever.
Combined immunotherapy encompassing intratumoral polyICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients
Authors: M.E. Rodríguez-Ruiz, J. Perez-Gracia, I. Rodriguez, C. Alfaro, C. Oñate, G. Perez, S. Inoges, L. Resano, A. Benito, B. Barbes, M. Ponz-Sarvisé, S Martin Algarra, A. Gurpide, M.F. Sanmamed, C. De Andrea, J. Echeveste, A. Salazar, I. Melero
Journal: Annals of Oncology (2017)
FISH BONES IN THE ESOPHAGUS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of income, hours worked, and loan repayment on medical students' decision to pursue a primary care career
Authors: M. P. Rosenthal
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess the specialty plans of current fourth-year medical students and, for those not choosing primary care specialties, to investigate the potential effect that changes in key economic or lifestyle factors could have in attracting such students to primary care. <h3>Design and Participants.</h3> —A survey study was sent to 901 fourth-year medical students in the 1993 graduating classes of six US medical schools. <h3>Outcome Measures.</h3> —Comparisons were made between students choosing and not choosing primary care specialties. For the non—primary care students, we also evaluated whether alteration of income, hours worked, or loan repayment could attract them to primary care careers. <h3>Results.</h3> —Of the 688 responses (76% response rate), primary care specialties were chosen by 27% of the students and non—primary care specialties by 73%. One quarter (25%) of the non—primary care students indicated they would change to primary care for one of the following factors: income (10%), hours worked (11%), or loan repayment (4%). For students whose debt was $50 000 or greater, the loan repayment option became much more important than for students with lesser debt. In all, a total of 45% (n=313) of the students indicated either they were planning to enter primary care (n=188) or they would change to a primary care specialty (n=125) with appropriate adjustments in income, hours worked, or loan repayment. <h3>Conclusion.</h3> —Significant changes in economic and lifestyle factors could have a direct effect on the ability to attract students to primary care. Including such changes as part of health system reform, especially within the context of a supportive medical school environment, could enable the United States to approach a goal of graduating 50% generalist physicians. (<i>JAMA</i>. 1994;271:914-917)
Disability Evaluation
Authors: Mark E. Battista
Journal: JAMA (1996)

Disability You can't tell a book by its cover, but if the range and depth of expertise of the editors and contributors are indicators, this new American Medical Association (AMA) text on disability evaluation should be a winner—and indeed it is! Demeter, Andersson, and Smith, all well known in the field of disability evaluation, have brought together an impressive group of 66 contributors representing all medical specialties and other disciplines such as economics, law, ergonomics, academic research, and occupational therapy.<i>Disability Evaluation</i>should become a core reference for any health care provider, attorney, vocational rehabilitation expert, and risk manager participating in some aspect of the increasingly complex disability benefits matrix. In addition to being the most current text on the subject, the book has many features that distinguish it from other tools for the process of disability evaluation, such as the AMA<i>Guides to the Evaluation of Permanent Impairment or</i>
Iron stores in blood donors
Authors: T. L. Simon
Journal: JAMA (1981)

A high frequency of donations by some blood donors has prompted concern about iron depletion. Five hundred sixteen female and 505 male donors were examined by measurements of hemoglobin, hematocrit, plasma iron, total iron-binding capacity, and ferritin values and detailed histories of iron ingestion, pregnancy and menstrual status, and past blood donations. Hemoglobin, hematocrit, and serum iron studies, unlike ferritin values, were not sensitive indicators of body iron depletion. Reduced iron stores were found in 8% of male and 23% of female donors. Menstruation significantly lowered iron stores in women. The total number of lifetime donations was not as predictive of decreased iron stores as frequency of donations per year. Even casual iron supplementation reduced the impact of donations on iron stores. Administration of iron to donors, especially menstruating women, should be studied by blood programs. (<i>JAMA</i>1981;245:2038-2043)
Regression of Hypernephromas
Authors: Willard E. Goodwin
Journal: JAMA (1968)

It is well documented that clear cell carcinomas of the kidney (hypernephromas) regress under certain circumstances. Bartley and Hultquist clearly illustrated this when they reviewed the literature and reported 26 of their own cases in 1950.<sup>19</sup> It is also known that, in some instances, distant metastases of clear cell carcinomas of the kidney have been known to regress or disappear.<sup>38,39</sup>Everson<sup>40</sup>reviewed and collected 21 acceptable cases of spontaneous regression of hypernephromas in 1964. Everson et al carefully documented 31 cases in 1966.<sup>22</sup>We have recently reviewed our own experiences<sup>37</sup>and described two new cases of regression of pulmonary metastases, and one case of regression of bony metastases. Most reported regressions have been<i>pulmonary</i>metastases where the diagnosis was presumptive and where microscopic study of the pulmonary lesion was not available. This has led some observers to question whether or not these "regressed" pulmonary metastases
M1/MUC5AC mucin released by human airways &lt;I&gt;in vitro&lt;/I&gt;
Authors: C. Labat, J. Bara, J-P. Gascard, H. Sossé-Alaoui, V. Thomas de Montpreville, M. Yeadon, C. Brink
Journal: European Respiratory Journal (1999)

Pulmonary alveolar proteinosis (PAP) is a rare disease of unknown aetiology characterized by accumulations of lipoproteinaceous material within the alveoli. The alveolar macrophages become increasingly foamy, and are thought to have a role in the pathogenesis of PAP. However, the mechanisms of macrophage recruitment are unclear. In the bronchoalveolar lavage fluid (BALF) of four patients with PAP and 20 normal control subjects, the following were examined: the monocyte chemotactic activity due to the chemokine monocyte chemoattractant protein (MCP)-1 with the use of a chemotactic chamber assay, the levels of MCP-1 by enzyme-linked immunosorbent assay, and the MCP-1 expression on lavage cells by immunocytochemistry and in situ hybridization. The monocyte chemotactic activity in the BALF of the PAP patients was markedly elevated, and the activity was completely absorbed by treatment with anti-MCP-1. The MCP-1 levels in the BALF were surprisingly high in the PAP group (25,100+/-472 pg x mL(-1)), whereas low levels of MCP-1 were detected in the normal control subjects (mean: never smokers 4.8; smokers 10.4 pg x mL(-1)). MCP-1 protein and messenger ribonucleic acid were expressed by macrophages from the PAP patients, and the expression was reduced according to foaming of the cells; there were monocyte-like macrophages with strong expression, small foamy cells with moderate expression, large foamy cells with a faint expression of MCP-1, and ghost cells with no expression. However, the increase of macrophage number in the PAP BALF was relatively small. These data suggest that monocyte chemoattractant protein(-1) expression by alveolar macrophages represents an amplification mechanism for the recruitment of additional macrophages to the alveoli in pulmonary alveolar proteinosis. It is possible that an ingestion of an excess of alveolar materials in pulmonary alveolar proteinosis may impair the macrophage function and the survival, resulting in the lack of a prominent increase in the macrophage number in bronchoalveolar lavage fluid.
Intervertebral Disks
Authors: Maurice L. Silver
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In the Sept. 24, 1960, issue of the<i>JAMA</i>(p. 353) there is a filler on intervertebral disks taken from the book by N. W. Faxon describing the Massachusetts General Hospital 1935-1955. This excerpt tends to perpetuate a fallacy that is prevalent in the New England area, namely, that Drs. Mixter and Barr were the first to operate for a protruded lumbar intervertebral disk. In the Oct. 19, 1929,<i>Archives of Surgery</i>, volume 19, pages 660-672, Dr. Walter E. Dandy wrote a paper entitled "Loose Cartilage from Intervertebral Disk Simulating Tumor of the Spinal Cord." He described the condition carefully, adding an excellent artist's sketch to show the pathologic anatomy, and stated clearly: "The lesion is undoubtedly of traumatic origin." I think it is important in this case to give credit where credit is due and to emphasize that the appreciation of the lesion and its successful
Mallet Finger
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac Toxicity of Aerosol Propellants
Authors: Alex Silverglade
Journal: JAMA (1972)

No longer may the fluorocarbon propellants used in pressurized bronchodilator aerosols be considered "inert"; nor should they be judged unsafe and a contributing cause of death in asthmatic patients. The facts are clearly established in the coniderable research of the past two years. These halogenated hydrocarbon propellants, sometimes called fluoroalkane or haloalkane gases, bear a number of trade names, the more common being Freon in the United States and Arcton in England. The various fluorocarbon compounds are designated by numbers. The propellants used in the bronchodilator aerosols in the United States include fluorocarbons 11, 12, and 114. Fluorocarbon will be represented here by the letter F. That exposure to fluorocarbon compounds in high concentration for five minutes was capable of sensitizing the hearts of conscious dogs to large intravenously given doses of epinephrine, resulting in serious cardiac arrhythmias, was first demonstrated by Reinhardt and associates<sup>1</sup>and was confirmed in
Medical malpractice and the tort system
Authors: Angela Gilchrist, William R. Hendee
Journal: JAMA (1990)

<h3>In Reply. —</h3> The main emphasis of the Council's recommendation for adequate fiber intake is on eating a variety of fiber-rich foods. Nuts are listed along with many other foods as good sources of dietary fiber. The National Institutes of Health considers foods with 1 to 3 g of fiber per serving to be "moderately rich" sources of food fiber and includes almonds and peanuts in a list of foods that are good sources of fiber.<sup>1</sup> Any food may have a place in the diet of healthy persons. It is a basic principle of nutrition that it is the composition of the total diet over an extended period, and not individual foods or ingredients per se, that determines nutritional status and contributes to health.
Neonatal granulocytosis is a postpartum event which is seen in the liver as well as in the blood
Authors: T Kawamura
Journal: Hepatology (1997)

In a recent series of studies, we demonstrated that stress in humans and animals, with resultant sympathetic nerve strain, induces severe granulocytosis, because granulocytes carry adrenergic receptors on the surface. Because activated granulocytes produce free radicals and superoxides, they sometimes induce tissue damage if the stress is too strong or continuous. Human neonates are also known to show high levels of granulocytes in the peripheral blood. In this study, we investigated whether such neonatal granulocytosis are a stress-associated response at birth. Both human and mouse materials, before and after birth, were used. The number of leukocytes in the blood, as well as some other factors in the serum, were measured. Although levels of granulocytes were found to be low in fetal humans and mice, they increased sharply after birth. In parallel with this postpartal granulocytosis, transaminases in sera increased transiently. In reference to results of a transient elevation in the levels of catecholamines at birth in mice, all these phenomena resemble stress-associated responses. Indeed, fatty liver and hematopoietic destruction in the liver were also observed in mice and humans. At this time, the production of inducible nitric oxide synthase (iNOS) by granulocytes in the liver was evident. These results suggest that neonatal granulocytosis is a postpartum event which results from various stresses (e.g., oxygen stress) at birth. This event may be responsible for such well-known neonatal phenomena as the termination of fetal hematopoiesis in the liver and as neonatal jaundice.
Carcinoembryonic antigen: its role as a marker in the management of cancer. Summary of an NIH consensus statement.
Journal: BMJ (1981)

Institutes of Health on 29 September-i October 1980 to address issues concerning the role of the carcinoembryonic antigen (CEA) as a marker in the management of cancer.NIH consensus development conferences bring together biomedical research scientists, practising physicians, consumers, and others with special interest or knowledge in an effort to reach general agreement on the scientific evaluation of a medical technology.That technology may be a drug, device, or labora- tory, medical, or surgical procedure.For this consensus con- ference, the members of the panel were limited to biomedical and clinical investigators actively working in the field, clinically involved in patient care, and familiar with the technology under assessment.The panel met after formal presentations and discussions to assess the issues based on the evidence presented.This summary is the result of its deliberations.
Erratum: Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice
Authors: C C Hoogenraad, B Koekkoek, A Akhmanova, H Krugers, B Dortland, M Miedema, A van Alphen, W M Kistler, M Jaegle, M Koutsourakis, N Van Camp, M Verhoye, A van der Linden, I Kaverina, F Grosveld, C I De Zeeuw, N Galjart
Journal: Nature Genetics (2002)
Screening for steatorrhoea with an oxalate loading test
Journal: BMJ (1984)

Seizures after antiemetic treatment with high dose domperidone: report of four casesThe judicious use of antiemetic treatment has made chemotherapy tolerable for a considerable number of patients.'As the dosage of antiemetic drugs is increased, however, so side effects-particularly in the central nervous system-are bound to increase in incidence and severity.We report the occurrence of seizures in four patients treated with high dose intravenous domperidone as prophylaxis against chemotherapy induced emesis.Clinical and biochemical data of patients who developed seizures while receiving high dose domperidone Amount of domperidone Case Serum electrolytes (mmol/l) Blood Blood administered before No Chemotherapy regimen sugar urea occurrence of seizures K+
Letter: Dangerous patients.
Journal: BMJ (1974)

221 exposures 4-5 days, figures which are very sinilar to those in our published series (11-7, 6-7, 4-6, 5-3 and 4-5 days respectively).We excluded fromn our analysis one patient found at necropsy to have a carcinoma of the bile duct and another with abnormal liver function tests who did not actually become jaundiced.More than 25 further