tbuckley/cabot-search huggingface dataset:
Bilateral optic neuropathy and osteolytic sinusitis. Complications of cocaine abuse
Authors: N. M. Newman
Journal: JAMA (1988)

COCAINE is a naturally occurring alkaloid of the coca plant<i>Erythroxylon coca</i>. Its psychopharmacological properties are due to stimulation of the central and sympathetic nervous systems by augmentation of the normal effects of the neurotransmitter norepinephrine. The Incas chewed coca leaves prior to 1000ADto "satisfy the hunger, provide the weary and fainting with new vigor and cause the unhappy to forget their miseries."<sup>1</sup> Recent increases in the production, trafficking, and use of cocaine have brought concomitant increases in associated medical problems.<sup>2,3</sup> The usual routes of illicit cocaine use are intranasal, intravenous, and inhalational. Each has unique medical hazards.<sup>4,5</sup>We describe a patient with unusual ophthalmic and otolaryngologic complications related to long-term intranasal abuse of cocaine. <h3>Report of a Case</h3> A 43-year-old man was referred to the Neuro-ophthalmology Service with bilateral decreased visual acuity and asymmetric optic nerve head swelling. The patient had noticed progressive
PHYSICAL CONDITION OF SCHOOL CHILDREN.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Information
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypothermia-Related Deaths—Alaska, October 1998-April 1999, and Trends in the United States, 1979-1996
Journal: JAMA (2000)

Hypothermia is defined as an unintentional lowering of the core body temperature to < or = 95 F (< or = 35 C) (1). It is a medical emergency with a high fatality rate (2). In the United States, hypothermia-related deaths can occur anywhere, including in states with milder climates (e.g., Georgia and North Carolina) where weather systems can cause rapid changes in temperature. However, the highest hypothermia-related death rates in the United States occur in northern states, where winter is characterized by moderate to severe cold temperatures (e.g., Alaska and Montana), and western states, where profound declines in nighttime temperatures may occur at high elevations (e.g., New Mexico). From October 1998 through April 1999, 16 deaths attributed to hypothermia (International Classification of Diseases, Ninth Revision [ICD-9], codes E901.0, E901.8, and E901.9; excludes man-made cold [E901.1]) were reported to the Alaska State Medical Examiner. This report describes selected cases of hypothermia-related deaths in Alaska during October 1998-April 1999; compares age-, sex-, and race-specific rates in Alaska and the rest of the United States during 1979-1996; and summarizes trends for hypothermia-related deaths in the United States during 1979-1996.
Aseptic Meningitis, Trimethoprim, and Sjögren's Syndrome-Reply
Authors: Stephen J. Derbes
Journal: JAMA (1985)

<h3>In Reply.—</h3> I have several comments to make concerning the observations of Dr de la Monte and colleagues. While sulfonamides are a frequent cause of untoward immunologic reactions, the association of some with the trimethoprim-sulfamethoxazole combination may be due, in certain instances, to the trimethoprim component. This was suggested in my report by the observation that, on one occasion, meningitis was associated with the ingestion of trimethoprim alone. It may therefore be erroneous to conclude that this patient had a "sensitivity to sulfa drugs." While my report acknowledges the occurrence of aseptic meningitis in Sjögren's syndrome,<sup>1</sup>the clinical picture of meningitis appears to be rather uncommon in this disease. Most publications dealing with Sjögren's syndrome (including a recently published reference text<sup>2</sup>) make no direct mention of it. The report by de la Monte et al<sup>3</sup>suggests that meningeal inflammation may be common in Sjögren's syndrome. Their patients
p-Nonyl-Phenol: An Estrogenic Xenobiotic Released from "Modified" Polystyrene
Authors: Ana M. Soto, Honorato Justicia, Jonathan W. Wray, Carlos Sonnenschein
Journal: Environmental Health Perspectives (1991)

Alkylphenols are widely used as plastic additives and surfactants. We report the identification of an alkylphenol, nonylphenol, as an estrogenic substance released from plastic centrifuge tubes. This compound was extracted with methanol, purified by flash chromatography and reverse-phase high performance liquid chromatography, and identified by gas chromatography-mass spectrometry. Nonylphenol induced both cell proliferation and progesterone receptor in human estrogen-sensitive MCF7 breast tumor cells. Nonylphenol also triggered mitotic activity in rat endometrium; this result confirms the reliability of the MCF7 cell proliferation bioassay. The estrogenic properties of alkylphenols, specifically nonylphenols, indicate that the use of plasticware containing these chemicals in experimental and diagnostic tests may lead to spurious results, and these compounds as well as alkylphenol polyethoxylates may also be potentially harmful to exposed humans and the environment at large.
Highlights
Journal: JAMA Pediatrics (2018)

Leventhal and colleagues conducted a prospective cohort survey of 2572 adolescents and collected data at baseline from January 2 through September 28, 2016 (11th grade), and at follow-up from January 1 through August 10, 2017 (12th grade), at 10 high schools in Los Angeles, California, recruited through convenience sampling.A total of 2572 students completed both surveys.Their outcomes were reported concern, worry, or stress regarding "increasing hostility and discrimination of people because of their race, ethnicity, sexual orientation/identity, immigrant status, religion, or disability status in society."They found that each 1-SD increase on the societal discrimination concern composite in 2016 was associated with more days of past-month cigarette (incidence rate ratio [IRR], 1.77; 95% CI, 1.42-2.20;P < .001),marijuana (IRR, 1.13; 95% CI, 1.01-1.26;P = .03),and alcohol (IRR, 1.11; 95% CI, 1.02-1.21;P = .01)use; more substances used (IRR, 1.07; 95% CI, 1.01-1.17;P = .04);and greater odds of depression (odds ratio, 1.11; 95% CI, 1.01-1.23;P = .04)and attention-deficit/ hyperactivity disorder (odds ratio, 1.12; 95% CI, 1.01-1.26;P = .04)symptoms in 2017.
The Cover
Authors: Jeanette M. Smith
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Promising Developments for Pancreatic Neuroendocrine Tumors
Journal: Cancer Discovery (2011)

Although their occurrence is rare, pancreatic neuroendocrine tumors (NET) are difficult to treat. By the time of diagnosis, most patients have advanced metastatic disease and their 5-year survival rate is below 43%. The only chemotherapeutic agent approved for treating NET—streptozocin, either alone or in combination with doxorubicin—has limited benefit for such advanced cases. Now, two new studies offer some optimism. Two phase III multicenter, double-blind, randomized, placebo-controlled trials have indicated that the drug sunitinib, an inhibitor of multiple tyrosine kinases, and everolimus, an inhibitor of mTOR, are effective against advanced pancreatic NET, even in patients in whom other treatments have failed.In a trial of 171 patients, sunitinib increased disease-free survival from 5.5 months to 11.4 months compared with placebo. Similarly, in a trial of 410 patients, everolimus improved progression-free survival from 4.6 months to 11 months. The authors estimated that 34% of patients treated with everolimus were alive and progression free at 18 months, compared with 9% who had received placebo. Based on these results and those of earlier trials, the FDA has granted everolimus priority review designation for the application of advanced NET. In October 2010, the FDA granted accelerated approval to everolimus for treatment of subependymal giant-cell astrocytomas associated with the autosomal dominant disorder tuberous sclerosis, and data from trials in breast cancer are expected at the end of this year. Everolimus was originally approved in March 2009 for the treatment of adults with advanced renal cell carcinoma whose disease was resistant to sunitinib or sorafenib.
The Role of Nurse Practitioners in End-of-Life Care—Reply
Authors: Michael W. Rabow, Joshua M. Hauser, Jocelia Adams
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The First Step
Authors: Jim McDermott
Journal: JAMA (1995)

When we started the health system reform debate, we aspired to a health care system characterized by universality, affordability, security, and choice. Nothing has happened to justify abandoning these health system reform goals. The number of uninsured Americans is increasing, and today almost 40 million of us are without coverage.<sup>1</sup>More employers are dropping insurance, and when people change jobs, their new employers are less likely to provide comparable health benefits.<sup>2,3</sup>In just 5 years, the average health insurance premium for a family will be $9500 per year, not including co-payments and deductibles, assuring that health insurance will be unaffordable to Americans who do not receive coverage through their employment (unpublished data, Congressional Budget Office, 1994). Those Americans who do have insurance are increasingly unable to choose their own physicians and hospitals. Involuntarily forced into managed care plans selected by their employers, more Americans lose their physician every
THE ANTIVIVISECTION BILL.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Baby Blues
Authors: Daniel J. Waters
Journal: JAMA (1982)

More than anything, it's the eyes that haunt you. All at once full of wonder, bewildered, yet somehow accusing. You can see almost anything you want in them if you look long enough. Trust perhaps? Or is it resignation? A glimmer of understanding that seems to vanish in an instant. It's always the eyes you remember. They lie in a sea of high-powered technology, some rocking gently on the water mattresses meant to simulate the womb from which they were thrust too fast, too soon, unprepared, and ill equipped. Small clenched fists not grasping rattles or brightly colored toys, but arterial lines and plastic tubing. Silent cries from babies whose first pacifier is an endotracheal tube. This is the world of an infant intensive care unit, a fluorescent, timeless place where children cry without sound and lullabies are barely audible above the gentle whoosh of the ventilators and the rhythmic
Free Serum Prostate-Specific Antigen and Screening for Prostate Cancer
Authors: Fritz H. Schröder
Journal: JAMA (1996)

<h3>To the Editor.</h3> —We read with great interest the article by Dr Catalona and colleagues.<sup>1</sup>We have performed a similar study in a screening population with quite similar results.<sup>2</sup>We used a different assay (Deltia ProStatus PSA Free/Total assay of Wallac Oy Company, Turkey, Finland) that automatically measures both free and total prostate-specific antigen (PSA) equimolarly at the same time in one sample. The most prominent conclusion from the article by Catalona et al is that percent free PSA (or free/total [F/T] ratio) increases specificity to predict positive prostate biopsies in men with prostate gland volume of 40 cm<sup>3</sup>or more in the PSA range between 4.0 and 10.0 ng/mL at a sensitivity level of 90%. In that group, 38% of biopsies could have been avoided at the cost of 10% loss of detection, independent of the result of digital rectal examination (DRE). In the subgroup of
ACTION OF HEPATIC, RENAL AND OTHER CELLS ON PHENOL AND INDOL, UNDER NORMAL AND PATHOLOGIC CONDITIONS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Saving Office Practice
Authors: Scott Matthew Bolhack
Journal: Annals of Internal Medicine (2004)

Letters18 May 2004Saving Office PracticeScott Matthew Bolhack, MDScott Matthew Bolhack, MDFrom Tucson Long-Term Care Medical Group, Inc., Tucson, AZ 85739.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-10-200405180-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Sox suggests in his editorial (1) that medical information technology will greatly improve the conditions of office practice, resulting in “saving” office practice for internists. I also believe that medical information technology will greatly improve the conditions of an office practice but unfortunately will not save it.The real reasons why office practice no longer meets the expectations of the internist are related to economics. Our nation is now faced with many trends that will challenge our current model of medical care, and this will also be true in the office. Physician assistants and nurse practitioners ...Reference1. Sox HC. Saving office practice [Editorial]. Ann Intern Med. 2003;139:227-8. [PMID: 12899590] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tucson Long-Term Care Medical Group, Inc., Tucson, AZ 85739. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSaving Office Practice Harold C. Sox Saving Office Practice Peter Basch Saving Office Practice Harold C. Sox Saving Office Practice Alan R. Ertle Metrics Cited byGen Y learners: just how concerned should we be?Evolving trends in balancing work and family for future academic physicians: a role for personal storiesETHICAL ASPECTS OF LIMITING RESIDENTS' WORK HOURSRepos de sécurité: quels enjeux?Work Hours Restrictions as an Ethical Dilemma for Residents: A Descriptive Survey of Violation Types and FrequencyTask transfer: another pressure for evolution of the medical professionTeaching internal medicine residents in the new eraWork-hour restrictions as an ethical dilemma for residentsReforming internal medicine residency trainingEthische Aspekte einer Begrenzung der ärztlichen ArbeitszeitSurgical residents' perceptions of the effects of the ACGME duty hour requirements 1 year after implementationDoes Resident Hours Reduction Have an Impact on Surgical Outcomes?1A case for the 80 duty-hour week 18 May 2004Volume 140, Issue 10Page: 844-845KeywordsComputersFellowshipsHospitalistsInformation technologyMotivationNursesResidencySoftware tools ePublished: 18 May 2004 Issue Published: 18 May 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE AMEBA CILIATA IN DISEASE, A NEW THEORY OF THE ORIGIN OF SOME OF THE ACUTE INFECTIOUS DISEASES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal