tbuckley/cabot-search huggingface dataset:
Patients who can't read. Implications for the health care system
Authors: S. Miles
Journal: JAMA (1995)

Our health care system requires that patients be able to read. The face-to-face words between a patient and physician embellish, reinforce, and personalize a larger framework of knowledge and learning that is transmitted through the written word. Given the increasing complexity of medical knowledge and the costs of medical illiteracy, inadequate literacy skills are an increasing barrier to good health care. In this issue ofThe Journal, Williams et al<sup>1</sup>show that many English-speaking and Spanish-speaking patients do not read well enough to adequately function in health care settings. The authors go beyond comparing reading ability with the difficulty of written health materials to quantitate how illiteracy can interfere with common tasks, such as understanding how to take medication or when the next appointment is scheduled. The study is limited in that it was conducted at only two public teaching hospitals and that it did not compare patients' ability
OP0015 Mortality of the cobra early rheumatoid arthritis trial cohort after 23 years follow up
Authors: P.B.M. Poppelaars, L.H.D. van Tuyl, M. Boers
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Mortality in patients with rheumatoid arthritis (RA) is higher than the general population. Most cohorts show that the adverse effect of RA becomes apparent only after more than a decade of follow up. Whether early, intensive treatment can improve this is still unknown. COBRA combination therapy (COmbinatietherapie Bij Rheumatoide Artritis) showed long-term effectiveness for treatment of early RA without undue harm.<sup>1</sup> In 2010, after 11 years of follow up, the COBRA follow up study showed lower mortality in patients with COBRA treatment compared to patients with sulphasalazine monotherapy.<sup>2</sup> <h3>Objectives</h3> Our aim was to investigate mortality in the COBRA-trial cohort after 23 years and compare this mortality to a reference sample of the general population in the Netherlands. <h3>Methods</h3> In the COBRA trial, patients with early RA (median disease duration, 4 months) were treated with sulphalasazine monotherapy (SSZ, n=79) or a combination of SSZ, low-dose methotrexate and initially high, step-down prednisolone (COBRA, n=76). In the current study, we investigated mortality in the COBRA trial with the help of the Dutch state registry for mortality (Centrum van familiegeschiedenis, CBG). We compared the mortality in this cohort to a reference sample of the general population in the Netherlands matched for age and gender (data from Statistics Netherlands). The Standardised Mortality Ratio (SMR) compared the trial groups and the general population. <h3>Results</h3> With data of 154 out of the 155 patients, follow up was nearly complete. Duration of follow up was mean 23 (in patients alive, range 22–24) years. In total 44 patients died (28%, SMR=0.80 [95% CI: 0.59 to 1.06]); 20 of 75 COBRA patients (27%, SMR 0.75; [0.47–1.14]) and 24 of 79 SSZ patients (30%, SMR 0.85 [0.56–1.25]); the difference in mortality was not significant (p=0.61). In the reference sample of the general population (n=154) 55 people (36%) died. The positive trend for COBRA over SSZ decreased over time (figure 1). <h3>Conclusions</h3> This prospective cohort study of early RA is one of the first to show a normalisation of RA mortality compared to the general population after 23 years of follow up. In fact, this trial population had a numerically lower mortality than expected. This confirms that early, intensive treatment of RA (that can include glucocorticoids) has long-term benefits, and strongly suggests these benefits include normalisation of mortality. <h3>References</h3> [1] Boers M, et al. Lancet1997;350:309–18. [2] van Tuyl LH, et al. Ann Rheum Dis2010;69:807–12. <h3>Disclosure of Interest</h3> None declared
Mucoid impaction of a bronchus
Authors: R. A. Mintzer
Journal: JAMA (1978)

<h3>Common</h3> Allergic bronchopulmonary aspergillosis (ABPA) Asthma, other allergic states <h3>Uncommon</h3> Bronchial adenoma Bronchial atresia Bronchogenic carcinoma Bronchogenic cyst Idiopathic mucoid impaction <h3>Diagnosis</h3> Allergic bronchopulmonary aspergillosis. <h3>Comment</h3> The posteroanterior chest roentgenogram of a 19-year-old asthmatic woman shows a poorly defined homogenous density in the left infrahilar region and linear (toothpaste) shadows extending upward and laterally from the left superior hilar region (Fig 1). A bronchogram shows marked dilation of the central bronchi in both the upper and lower lobes, with a relatively normal appearance peripherally (Fig 2). The homogenous densities demonstrated on the chest roentgenogram conform to the areas of dilated central bronchi and are the result of plugging of these bronchi by retained mucus secretions. Mucoid impaction of a bronchus may result from a number of causes. The impaction is proximal and extends into second-, third-, and fourthorder bronchi, which are filled with
Professional courtesy survey
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massage; Its Mode of Application and Its Effects.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Explanation.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Geotrichum Septicemia
Authors: Thomas W. Sheehy
Journal: JAMA (1976)

Although disseminated geotrichosis is an unusual disease (to our knowledge, only six cases have been reported),<i>Geotrichum candidum</i>is not a very virulent fungus. In our case, there was neutrophilic phagocytosis of the arthrospores of<i>G candidum</i>, with rapid clearance of the fungus from the plasma of a chronically ill patient whose immune defenses were still intact. (<i>JAMA</i>235:1035-1037, 1976)
A review of interventional clinical trials (CTs) in renal cell carcinoma (RCC): A status report from the ClinicalTrials.gov website.
Authors: Matthew R. Zibelman, Peter Barth, Elizabeth Handorf, Marc C. Smaldone, Alexander Kutikov, Robert G. Uzzo, Marijo Bilusic, Elizabeth R. Plimack, Yu-Ning Wong, Daniel M. Geynisman
Journal: Journal of Clinical Oncology (2014)

e15542 Background: Therapy (Tx) and CTs in RCC have rapidly evolved with the introduction of targeted therapy (TT) and more recently novel immunotherapy (IT). The objective of this study was to assess the current landscape of CTs in RCC to identify areas of strength and opportunities for improvement. Methods: ClinicalTrials.gov was queried on September 24, 2013 using pre-specified search criteria. Only open, RCC-dedicated, interventional CTs in adult patients (pts) were included. Descriptive statistics and Fisher’s exact tests were used to compare features of CTs. Results: Of the 169 CTs analyzed, 42 were phase I or I/II (25%), 67 phase II (40%), 15 phase III (9%), and 45 other (26%). Overall, 27% were randomized and 65% were single-arm. Most CTs were at least partially based in the U.S. (68%) and 16% were industry sponsored. The majority of CTs allowed any histology (60%), but 31% were for clear cell RCC only and 9% were for strictly non-clear cell RCC. Studies of pts with advanced disease (AD) comprised 67% of the CTs, 15% were surgery CTs, 11% were studying pts in a neo-adjuvant or adjuvant setting and 7% were other. Of the CTs evaluating pts with metastatic disease, 30% were for 1st line Tx, 40% for 2nd line or beyond and 30% for any line Tx. TT was the most commonly studied systemic Tx, with 57% of all CTs including at least one TT. IT was tested alone or in combination in 8%. The primary endpoint of feasibility or biomarker analysis, progression free survival (PFS), or overall survival (OS) was noted in 28%/52%/2% of TT CTs and 43%/36%/14% of IT CTs (P=0.037). Biomarkers were assessed in 45% of CTs overall and were more frequently examined in TT and IT CTs (54% and 64%) than in surgery and other CTs (22% and 28%) (P=0.002). Sponsorship differed by Tx type (P=0.003), with IT CTs most commonly sponsored by industry (36%), and academic sponsorship more common for TT (46%), surgery (89%) and other (63%) CTs. Conclusions: CTs in RCC are largely non-randomized, single arm, with minimal focus on non-clear cell RCC and evaluating primarily pts with AD. TT is the predominant systemic Tx being tested. Significant differences were noted in the primary endpoint, sponsorship and biomarker assessment between Tx types.
Tell Me
Authors: George Young
Journal: Annals of Internal Medicine (2002)

Ad Libitum5 November 2002Tell MeGeorge Young, MDGeorge Young, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-5_Part_1-200209030-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Tell me the night silenceon the locked Alzheimer's ward is brokenby a yell from room 206,that an old man with flattenednose and crumpled ears,whose family moved away to Arizona,whose doctor never comesto visit, is standingin the middle of that room, naked,his freckled face a clenched fist,urine and feces runningdown his legs.Then tell me that the fat one, twelveyears on the job,working her second shift becausesomeone's car won't start,comes with a panof warm water, a sponge and a towel; how, back in bed, hecries, You know—I'm in the ring tomorrow with Killer; how a tiny smile ... Author, Article, and Disclosure InformationAffiliations: Current Author Address: George Young, MD, Boulder Medical Center,2750 Broadway, Boulder, CO 80304. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 November 2002Volume 137, Issue 9Page: 769KeywordsAlzheimer diseaseFatsRunningUrine ePublished: 5 November 2002 Issue Published: 5 November 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clonal integration and expression of human T‐cell lymphotropic virus type I in carriers detected by polymerase chain reaction and inverse PCR
Authors: Koichi Ohshima, Yasuo Mukai, Hiroshi Shiraki, Junji Suzumiya, Koutaro Tashiro, Masahiro Kikuchi
Journal: American Journal of Hematology (1997)

Adult T-cell leukemia (ATL) is a neoplasm of mature helper (CD4) T lymphocytes, and human T-cell lymphotropic virus type-I (HTLV-I) has been suggested to be the causative virus of ATL. HTLV-I integrates its proviruses into random sites in host chromosomal DNA. Clonal integration has been observed in patients with ATL, including smoldering, chronic, and acute states. However, random and/or polyclonal integration has only been reported in a few asymptomatic HTLV-I carriers. To clarify the clonality of HTLV-I-infected cells in carriers, we used an inverse polymerase chain reaction (IPCR), which is more sensitive than Southern blot analysis. We used the peripheral blood momonuclear cells (PBMC) from 16 asymptomatic carriers and the separated CD4-positive cells. No cases showed either a monoclonal or polyclonal integration of the HTLV-I provirus by Southern blot. But, using IPCR, 7 of 16 cases showed either mono- or oligoclonal integration. In addition, the populations of clonal provirus in the total PBMC were frequently different from those in the CD4-positive cells. Three cases showed expression of HTLV-I tax/rex mRNA in the total PBMC, but no such expression was found in CD4-positive cells. In this study, an unexpected frequency of clonal HTLV-I provirus DNA was observed in HTLV-I carriers. These findings indicate that the clonal but nonmalignant proliferation of HTLV-I-infected cells already occurs even in HTLV-I carriers, and therefore that some other step is necessary to induce malignant proliferation. Am. J. Hemato. 54:306–312, 1997. © 1997 Wiley-Liss, Inc.
THE AUTO IN A MUDDY COUNTRY.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ueber Grippepsychosen.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reduction of Bacteriuria and Pyuria Using Cranberry Juice
Authors: Jose Mandigers
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Dr Avorn and colleagues<sup>1</sup>reported a clinical trial showing that drinking cranberry juice may reduce the incidence of bacteriuria in elderly women. The idea that cranberry juice reduces the probability of infection is an old one, but has rarely been studied thoroughly. Cranberries were introduced to the Netherlands when an American ship was wrecked on the Dutch coast, and crates with cranberries washed ashore on a small island called Terschelling. The cranberries seeded and are now cultivated on this island. We looked at the cranberry/bacteriuria problem in another way, using a randomized controlled cross-over design. This technique avoids problems due to great variation in elderly individuals' general condition, drinking habits, and urinary continence. From the end of 1992 until early 1994, a study was done in a nursing department of a general hospital, including persons who had hospital treatment and were waiting for transfer to a
INCREASE OF CANCER.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROGNOSIS OF MENINGOCOCCAL SEPTICAEMIA
Authors: F. Leclerc, ElsayedAhmed Abdalla, Per Bjark, TrulsW. Gedde-Dahl, E.Arne Høiby, JohanN. Bruun, Petter Brandtzeag, Andreas Skulberg, J.F. Sinclair, C.H. Skeoch, D. Hallworth
Journal: The Lancet (1987)
Errors in Nomenclature
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeting PKC: A Novel Role for Beta-catenin in ER Stress and Apoptotic Signaling
Authors: Marc S Raab, Iris Breitkreutz, Giovanni Tonon, Jing Zhang, Johannes Fruehauf, Boris K Lin, Dharminder Chauhan, Teru Hideshima, Nikhil Munshi, Kenneth C. Anderson, Klaus Podar
Journal: Blood (2008)
Editorial: Preventing animal diseases.
Authors: James Howie, M Mr
Journal: BMJ (1976)

As reported inThe Times' and the Veterinary Record,2 Mr Hugh-Jones and his colleague Mr Ellis think that there is no difficulty about setting up a system to monitor animal diseases; but Mr Hugh-Jones is quoted as saying that "nobody should move until five deceptively simple questions are answered."What information is needed?Why is it needed?Who needs it?How much time and money are available ?And, probably most important of all, what is going to be done with the information when it is obtained