tbuckley/cabot-search huggingface dataset:
Commentary
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of babesiosis in asplenic patients
Authors: A. B. Bredt
Journal: JAMA (1981)

PROTOZOA of the genus<i>Babesia</i>are tick-borne intraerythrocytic parasites that are transmitted to many species of wild and domesticated animals. Human infection shows two different patterns dependent on immunologic status. In the host with an intact spleen, the infection either is asymptomatic<sup>1</sup>or causes a moderately severe, febrile, hemolytic illness.<sup>2</sup>However, these patients invariably recover with only symptomatic care. In contrast, splenectomized persons experience overwhelming intraerythrocytic infections with high fevers, severe toxic reactions, renal failure, and hepatic decompensation.<sup>3</sup>The outcome in these cases has frequently been fatal.<sup>4</sup>To date, no chemotherapeutic agent has been found to be active against this parasite in man.<sup>5</sup> We recently encountered a critically ill splenectomized patient with babesiosis who responded clinically to quinine sulfate treatment with prompt defervescence and rapid reduction in the level of parasitemia. <h3>Report of a Case</h3> A 36-year-old man entered the Kaiser Foundation Hospital, Panorama City,
Urology
Authors: M. S. Litwin
Journal: JAMA (1995)

The medical outcomes and practice guidelines movements profoundly affected the field of urology in 1994 with the long-awaited publication of the<i>Clinical Practice Guideline for Benign Prostatic Hyperplasia</i>(BPH) from the US Agency for Health Care Policy and Research.<sup>1</sup>Intended for use by primary care providers as well as urologists, the guideline provides a straightforward algorithm for the diagnosis and treatment of obstructive urinary symptoms in men older than 50 years. It is an evidence-based guideline, developed by a multidisciplinary panel of experts during several years of work.<sup>2</sup> In the guideline, diagnostic evaluation relies heavily on the patient's own symptom assessment using the American Urological Association Symptom Index, a seven-item questionnaire that focuses on incomplete emptying, weak or intermittent stream, urgency, hesitancy, and nocturia.<sup>3</sup>This questionnaire is a psychometrically valid and reliable self-administered instrument that scores obstructive voiding symptoms on a scale from 0 to 35, with
A healthy diet and physical activity can help reduce your cancer risk
Journal: CA A Cancer Journal for Clinicians (2020)

This patient information sheet contains advice from the American Cancer Society about how good nutrition and physical activity can help you reduce your risk of cancer. How Can I Use These Guidelines?If you aren't already following our advice and want to make changes, remember that it's OK to start slowly.Small steps can add up to big changes!Get to and Stay at a Healthy Weight Throughout Your Life • If you are overweight or obese, losing even a few pounds can lower your risk for some forms of cancer (and other serious health problems).• The best way to get and stay leaner is to combine a healthy diet with plenty of physical activity.Aim for the right weight by learning about your body mass index (BMI).Even if you don't reach your ideal weight, eating well and being active can improve your health, help you feel better, and help protect you against cancer.
Bacteriological Studies in Pulmonary Atelectasis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1742: Expression of the Anti-Angiogenic Proteins Angiostatin and Endostatin is Increased in Diabetic Patients and Associated with Impaired Coronary Collateral Formation
Authors: Neel R Sodha, Munir Boodhwani, Richard T Clements, Shu-Hua Xu, Roger L Laham, Frank W Sellke
Journal: Circulation (2007)

Introduction: Coronary artery disease is the leading cause of mortality in diabetics. Due to the diffuse nature of their disease, diabetics may be at risk for incomplete revascularization, highlighting a potential role for pro-angiogenic therapy in this group. This study investigates molecular mechanisms of angiogenesis in diabetics. Methods: Myocardial tissue was harvested from patients undergoing CABG (non-diabetic (ND) 11, type 2 diabetic (DM) 10). Expression of angiostatin, endostatin, their precursors (plasminogen and collagen XVIII, respectively), enzymes leading to their production (Matrix Metalloprotease (MMP) 2 &amp; 9), and an inhibitor of MMPs (TIMP2) was assessed with western blotting. MMP activity was assessed. Serum levels of angiostatin and endostatin were assayed. Coronary collateralization was graded by Rentrop scoring of angiograms. Results: Plasminogen and collagen XVIII expression were similar between groups. Angiostatin expression trended to increase 1.24-fold (p=0.07) and endostatin expression increased 2.02-fold in DM patients relative to ND (p=0.02). Serum angiostatin was 2.68-fold higher (p=0.03) and endostatin 1.39-fold higher (p=0.04) in diabetics. MMP9 expression was no different between groups, whereas MMP2 expression decreased 1.8-fold in diabetics (p=0.003). MMP2 &amp; 9 activity decreased 1.33-fold (p=0.03) and 1.57-fold (p=0.04), respectively, in diabetics. Coronary collateralization scores were ND 2.1 ± 0.37 vs. DM 1.0 ± 0.4 (p=0.05). Myocardial endostatin expression correlated strongly with %HbA1c (R=0.742, p=0.0001). Myocardial expression of angiostatin and endostatin demonstrated significant negative linear correlations with coronary collateralization (angiostatin R=−0.531, p=0.035, endostatin R=−0.794, p=0.0002). Conclusion: Diabetics exhibit increased levels of the anti-angiogenic proteins angiostatin and endostatin and differential regulation of the enzymes governing their production relative to non-diabetics. Myocardial levels of these proteins show significant correlation to coronary collateralization. These findings offer potential new therapeutic targets for enhancing pro-angiogenic therapy and insight in to the angiogenic impairments seen in diabetes.
WHY WE SHOULD HAVE A MEDICAL OFFICER IN THE PRESIDENT'S CABINET.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The risk of in utero exposure to lithium
Authors: C. H. Kellner
Journal: JAMA (1994)

<h3>In Reply.</h3> —We are pleased that Drs Kellner, Beale, and Pritchett appreciate our recent attempt to describe a revised estimate of risk associated with in utero exposure to lithium carbonate. It was one of our main goals to underscore the clinical implications of a more modest risk associated with first-trimester exposure to lithium with respect to the clinical management of women with bipolar disorder who were planning to conceive or who inadvertently became pregnant. While the safe use of ECT during pregnancy has been well described,<sup>1</sup>good follow-up studies of these pregnancies are limited.<sup>2</sup>While it may not be safer than psychotropic drug use during pregnancy, ECT is clearly the treatment of choice for psychiatrically ill pregnant women when expeditious treatment is imperative such as in the setting of mania or psychotic depression, where the risk of untreated disorder, ie, danger from impulsive behaviors, psychosis, and self-harm, place
Cooperative study of hospital frequency and character of transient ischemic attacks. IV. The reliability of diagnosis
Authors: P. R. Calanchini
Journal: JAMA (1977)

All patients (1,328) suspected of having transient ischemic attacks (TIA) who came to six institutions over a 21-month period were identified. Each case was reviewed by a neurological investigator, and a definite diagnosis of TIA was supported in 39% and ruled out in 30%. The reliability of the neurologist's review diagnosis was assessed by three methods, and close agreement (84% to 93%) was obtained. Factors demonstrated to effect the diagnosis were historical information, neurological training of the examiners, type of symptom complex, presence of carotid artery bruits, and examination during an attack. (<i>JAMA</i>238:2029-2033, 1977)
Tremor
Authors: M. Pipis, M. Dehabadi, E. Matthews, L. Gould
Journal: BMJ (2013)

A middle aged man presents complaining of excessive shaking of his hand. Physical examination reveals bilateral hand tremor, right more so than the left, and worse when holding his arms outstretched. The remainder of the physical and neurological examinations are normal. Tremor is the most common involuntary movement encountered in clinical practice. It is an unintentional, rhythmic muscle movement that usually affects the hands but can also affect the arms, head, legs, and rarely the trunk. Essential tremor is the commonest form, but tremor may sometimes be a symptom of an underlying neurological disorder or a manifestation of systemic disease, and patients are often worried about a diagnosis of Parkinson’s disease. ### History #### Medical history
Allergy abstracts
Authors: David Stein, Harold Friedman, Cleveland Ohio, Monroe Stamford, Walzer Bridgeport, N Berger Freehold, Stein Jeremiah, Bert Cleveland, Tyler Kahn, J Andre, N Codispoti Sufieern, Y Robert, New Lin, N York, Randolph Christopher
Journal: Journal of Allergy and Clinical Immunology (1987)
CALIFORNIA HEALTH INSURANCE BILL
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapy with progestational agents in advanced benign prostatic hypertrophy
Authors: J. Geller
Journal: JAMA (1969)

Eleven patients with benign prostatic hypertrophy (BPH) and urinary retention requiring catheter drainage in all cases except one, were treated with either hydroxyprogesterone caproate (eight patients) or chlormadinone acetate (three patients) for 3 to 16 months continuously. Six patients voided spontaneously with less than 50 ml residual urine within three months; in two others, similar results occurred after five months of treatment. Three patients were unresponsive to therapy. Among a control group of ten patients with BPH and retention requiring catheter drainage, only two voided spontaneously with less than 50 ml residual urine after two months, a statistically significant difference from the treated group. Of eight patients responding favorably to treatment, residual urine, symptoms of prostatism, and renal function remained stable for an average follow-up of 13 months following discontinuation of therapy.
Digital computer processing of radioisotope scintiscan matrices
Authors: W. N. Tauxe
Journal: JAMA (1968)

Our findings so far at the Mayo Clinic have suggested that the digital computer constitutes a tool of major importance in the processing and handling of scintiscan matrices. All data accumulated in the course of scanning, along with correct x-y orientation, are tape recorded in computer-compatible format and fed into a high-speed digital computer for reconstitution of the scan matrix. Improvement has been manifested by finding more filling defects, defining areas totally void of activity, providing better resolution, and obtaining greater detail. Of perhaps even greater importance is the ability of the computer to quantitate activity in terms of actual gamma rays per character. Since it handles low count rates better than the photoscan does, it can provide a combination of thyroid-uptake data and scan information on usual thyroid-uptake doses (5μc in the cases presented). These scans are cheaper than the usual photoscans, both in the amount of electronic equipment needed and in the cost of the film, film processing, and storage.
Electrocardiographic artifacts caused by defective marker circuitry
Authors: W. C. James
Journal: JAMA (1982)

<h3>In Reply.—</h3> We appreciate the opportunity to respond to Dr Tack's letter. We agree that there is considerable variability in CSF drug levels. In most cases, drugs that exhibit marked variability in CSF concentration are not used, and physicians are informed that higher doses would normally be employed in the treatment of meningitis. Moreover, the flexibility of our system is such that as more data concerning CSF levels of new drugs, eg, cefotaxime and moxalactam becomes available, it would be reflected in the CSF IQs. We recognize that numerous factors may alter the concentration and, hence, activity of antimicrobial agents both in tissues and body fluids.<sup>1</sup> The conditions that obtain in in vitro determinations of MICs or serum bactericidal levels do not approximate those that exist at the site of infection in the body. Furthermore, the methodology employed in such determinations (medium and inoculum size) are variable. However, arbitrarily
Prevention of recurrent staphylococcal skin infections with low-dose oral clindamycin therapy
Authors: M. S. Klempner
Journal: JAMA (1988)

We conducted a double-blind, controlled trial of low-dose (150 mg/d) oral clindamycin hydrochloride vs placebo to prevent recurrent staphylococcal skin infections. Twenty-two patients (11 in both the placebo and clindamycin treatment groups) completed the trial and were assessable. The two groups did not differ as to age, sex, race, or the number of recurrent abscesses preceding the trial. In pretrial evaluations, no patient had hypogammaglobulinemia or abnormal neutrophil function. Sixty-four percent (7/11) of the placebo-treated patients had a recurrent abscess within three months of enrollment whereas 82% (9/11) of the patients treated with clindamycin were free of any infection during the three-month treatment period. Of the nine patients who responded to clindamycin treatment, six did not have a recurrent infection for at least nine months after discontinuing antibiotic therapy. All patients tolerated the regimen without side effects. We conclude that a three-month course of low-dose oral clindamycin is an effective, convenient, well-tolerated, and often durable approach to prevention of recurrent staphylococcal skin infections. (<i>JAMA</i>1988;260:2682-2685)
PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome
Authors: Inga Ebermann, Jennifer B. Phillips, Max C. Liebau, Robert K. Koenekoop, Bernhard Schermer, Irma Lopez, Ellen Schäfer, Anne-Francoise Roux, Claudia Dafinger, Antje Bernd, Eberhart Zrenner, Mireille Claustres, Bernardo Blanco, Gudrun Nürnberg, Peter Nürnberg, Rebecca Ruland, Monte Westerfield, Thomas Benzing, Hanno J. Bolz
Journal: Journal of Clinical Investigation (2011)

In the section of Methods titled "Antibodies and flow cytometric analysis," the antibody clone name for the anti-Tim-3 antibody was given incorrectly.The correct sentences appear below: Directly conjugated antibodies against the following surface molecules were used: CCR7-PE-Cy7 (clone 3D12), CD27-APC-H7 (clone M-T271), CD45RA-APC (clone HI100), CD69-FITC (clone L78), HLA-DR-PerCP (clone L243), CD45RO-PE-Cy7 (clone UCHL1), CD3-Pacific Blue (clone UCHT1), CD4-V500 (clone RPA-T4), CD8-Alexa Fluor 700 or CD8-PerCP (clone SK1), and PD-1-FITC (clone MIH4), all from BD Biosciences.The PE-conjugated antibody and the blocking antibody for Tim-3 (clone 344823) were obtained from R&D; the blocking antibody gave results that were comparable to those of 1G5 anti-Tim-3 antibody, provided by
Commentary
Authors: Michael J Callaghan
Journal: British Journal of Sports Medicine (2000)

Background-Despite massage being widely used by athletes, little scientific evidence exists to confirm the eYcacy of massage for promoting both physiological and psychological recovery after exercise and massage eVects on performance.Aim-To investigate the eVect of massage on perceived recovery and blood lactate removal, and also to examine massage eVects on repeated boxing performance.Methods-Eight amateur boxers completed two performances on a boxing ergometer on two occasions in a counterbalanced design.Boxers initially completed performance 1, after which they received a massage or passive rest intervention.Each boxer then gave perceived recovery ratings before completing a second performance, which was a repeated simulation of the first.Heart rates and blood lactate and glucose levels were also assessed before, during, and after all performances.Results-A repeated measures analysis of variance showed no significant group diVerences for either performance, although a main eVect was found showing a decrement in punching force from performance 1 to performance 2 (p<0.05).A Wilcoxon matched pairs test showed that the massage intervention significantly increased perceptions of recovery (p<0.01)compared with the passive rest intervention.A doubly multivariate multiple analysis of variance showed no diVerences in blood lactate or glucose following massage or passive rest interventions, although the blood lactate concentration after the second performance was significantly higher following massage (p<0.05).Conclusions-These findings provide some support for the psychological benefits of massage, but raise questions about the benefit of massage for physiological restoration and repeated sports performance.
Postpartum rubella vaccination. A survey of private physicians in oregon
Authors: L. V. Cheldelin
Journal: JAMA (1973)

One hundred forty-two private physicians who had submitted prenatal blood specimens on 278 rubella-susceptible pregnant women were contacted to determine whether the women had been vaccinated post partum. Only eight physicians had vaccinated at least one patient in this sample population with the result that only 13 of the 278 susceptible women were vaccinated. "Difficulty of follow-up," "physician reluctance," "referred to another physician," and "negative titer not noticed" were usual reasons given for failure to vaccinate. The easiest way to assure that rubella-susceptible women will be protected against rubella is to include vaccination as part of postpartum care, before the women are discharged from the hospital.
Denial. Are sharper definitions needed?
Authors: N. Cousins
Journal: JAMA (1982)

THE TERM<i>denial</i>, when used clinically, is applied to patients who, consciously or unconsciously, try to relieve their anxiety by pretending that the serious situation described to them by their physicians is either exaggerated or nonexistent. I write here about three cases in which the term was used. The basic facts in each case, however, indicate that the term may have been misapplied. It should be pointed out that the patients, while understandably anxious and apprehensive, were not considered to be neurotic or psychotic. My knowledge of the cases was based on information from the patients. Patient 1 was a 43-year-old woman who was an ambulance driver and paramedic. A mammogram and a biopsy specimen of a small lump in her breast led to the recommendation of a radical mastectomy. The patient declined to accept surgery. The physician, disturbed by her apparent denial of her condition, suggested she see a