tbuckley/cabot-search huggingface dataset:
Controlled Trial of Naturalistic Dawn Simulation and Negative Air Ionization for Seasonal Affective Disorder
Authors: Michael Terman
Journal: American Journal of Psychiatry (2006)

Objective: This trial assessed two novel nonpharmaceutical treatments for winter depression—naturalistic dawn simulation and high-density negative air ionization—delivered during the final hours of sleep. Method: The patients were 99 adults (77 women and 22 men) with the winter seasonal pattern of major depressive disorder (94 cases) and bipolar II disorder (five cases). Five parallel groups received 1) dawn simulation (0.0003–250 lux in the pattern of May 5 at 45° north latitude); 2) a dawn light pulse (13 minutes, 250 lux, with an illuminant dose of 3.25×10 3 lux-minutes matched to the simulated dawn); 3) postawakening bright light (30 minutes, 10,000 lux); 4) negative air ionization at high flow rate (93 minutes, 4.5×10 14 ions/second); or 5) ionization at low flow rate (93 minutes, 1.7×10 11 ions/second). The symptoms were assessed over 3 weeks with the Structured Interview Guide for the Hamilton Depression Rating Scale—Seasonal Affective Disorder Version. Results: Posttreatment improvement results were bright light, 57.1%; dawn simulation, 49.5%; dawn pulse, 42.7%; high-density ions, 47.9%; and low-density ions, 22.7% (significantly lower than the others). Contrary to the authors’ hypothesis, analysis of variance failed to find superiority of dawn simulation to the dawn pulse or bright light. However, the dawn pulse led to a pattern of residual or exacerbated depressive symptoms similar to those seen in low-density ion nonresponders. Conclusions: Naturalistic dawn simulation and high-density ionization are active antidepressants that do not require the effort of postawakening bright light therapy. They can be considered candidate alternatives to bright light or medication.
MILK CONSUMPTION IN THE UNITED STATES
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DeCoN: Genome-wide Analysis of In Vivo Transcriptional Dynamics during Pyramidal Neuron Fate Selection in Neocortex
Authors: Bradley J. Molyneaux, Loyal A. Goff, Andrea C. Brettler, Hsu-Hsin Chen, Juliana R. Brown, Siniša Hrvatin, John L. Rinn, Paola Arlotta
Journal: Neuron (2016)
An Address Delivered at the Opening of the Section of Otology
Authors: G. P. Field
Journal: BMJ (1889)

b~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~t his case in Mlay, 1888, Mir.Tweedy writes: "'The extraction was uncomplicated, and the lens left the capsule entire.Re- covery was prompt, and a few weeks later, with suitable glasses, the patient could read 'brilliant' type quite fluently.Since that operation I have rarely refused to extract a cata- ract, no matter how immature, whenever both eyes were so affected that the patient was unable to earn his livelihood." The success which so far I have had I ascribe entirely to the kind of operation wlhich I have been in the habit of performingnamely, a corneal section upwards with a Graefe's knlife, with an iridectomy, and a peripheral section of the capsule of the lens with the cataract knife, leaving the anterior capsule, as far as practicable, intact.By this means the lens is taken, as it were, out of a pocket."Mr. Tweedy claims that any lens matter which is left behind remains within the capsule to which the aqueous humour finds ready access, causing disintegration, liquefaction, and absorption, so that in due time, in the large majority of cases, a perfectly transparent capsule remains; while in those rare instances where
Convulsions associated with amoxapine
Authors: J. W. Jefferson
Journal: JAMA (1984)

<h3>In Reply.—</h3> We can assure Drs Kulig and Rumack that the patient who had convulsions for nine hours promptly received maximal therapeutic doses of four anticonvulsants as well as neuromuscular blocking agents to control the major motor activity. Indeed, it was this difficulty controlling amoxapine-induced convulsive activity with rigorous medical management that focused our attention on the problem with this drug. Unfortunately, detailed descriptions of five severe cases were deleted in the editorial process. In the 16 months since our study ended, 18 amoxapine overdoses were reported to the National Capital Poison Center. Of these, seizures were noted in five cases (27.8%), with status epilepticus in four of these cases. One fatality occurred, two additional patients suffered permanent neurological impairment clearly caused by the amoxapine overdose (including an 18-month-old child), and one additional patient suffered a permanent frontal lobe deficit possibly related to amoxapine (other drugs were ingested). Thus, overall,
Highlights
Journal: JAMA Pediatrics (2020)

Public Health Insurance Expansion for Immigrant Children 22Yasenov and colleagues conducted a difference-in-differences analysis to examine whether expanding public health insurance in some states to non-US-born children and pregnant women who are lawful permanent residents during their first 5 years of residency in the United States is associated with increased interstate migration among these groups.Their findings suggest that states expanding health care benefits for immigrant children and pregnant women may be unlikely to experience changes in in-migration among eligible non-US-born adults from other states.
CARL FREDERICK WILHELM LUDWIG (1816-1895) MODERN PHYSIOLOGIST
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FANTASTIC THEORIES OF THE CAUSE OF APPENDICITIS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
First Infection-fighting Monoclonal Antibodies Scrutinized by FDA Advisory Committee Members
Authors: Charles Marwick
Journal: JAMA (1991)

AGENTS against some gram-negative infections are moving closer to receiving the Food and Drug Administration's (FDA's) green light. If these agents are licensed, they will be the first monoclonal antibodies available for clinical use in the United States. Members of the FDA's Advisory Committee on Vaccines and Related Biological Products have heard from two manufacturers of these monoclonal antibodies that studies show a reduction in mortality and morbidity in patients with gram-negative sepsis. While the committee has made no formal recommendations to the FDA commissioner for licensure of these products, the members do agree that one of them, Centoxin (HA-1A) (Centocor Inc, Malvern, Pa), could get the green light if the types of patients in which it is most likely to be useful can be identified with reasonable precision. The committee also says that if data analysis on the other product, E5 (Xoma Corp, Berkeley, Calif), shows similar efficacy, it,
Prolonged doxapram infusion in obesity-hypoventilation syndrome
Authors: W. C. Houser
Journal: JAMA (1978)

Doxapram hydrochloride, a potent, centrally acting respiratory stimulant, is used to treat acute respiratory insufficiency caused by anesthetic administration,<sup>1</sup>drug overdose,<sup>2</sup>and chronic obstructive pulmonary disease.<sup>3</sup>We used it to treat acute respiratory failure due to the obesity-hypoventilation syndrome because the patient's condition did not improve with conventional therapy. <h3>Report of a Case</h3> A 39-year-old woman came to the hospital because she felt depressed. She also had dyspnea after walking ten to 12 steps. Her son reported that she slept approximately 12 hours per day and was difficult to arouse. She reported a weight gain of approximately 45 kg over the past year, had had pedal edema for the past four months, and there was recent onset of periorbital edema. The patient had been overweight since her teens, when she weighed 81 kg. Because of emotional stress precipitated by family problems, she began to eat excessively. Both
The Blurred Intersection of Beneficence, Competence, and Autonomy
Authors: Keith Wrenn
Journal: Annals of Internal Medicine (1993)

Letters1 October 1993The Blurred Intersection of Beneficence, Competence, and AutonomyKeith Wrenn, MDKeith Wrenn, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-7_Part_1-199310010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Harrow's anger was initially very discomfiting, but I believe his emotion suggests that my story was successful; it has stimulated discussion. Therefore, I thank him for voicing his opinions. I'm not entirely sure where his anger is directed, but I think it is directed at me.At the risk of responding too superficially to the issues raised, I feel three important concepts bear pointing out: 1) Motivation was neither ethnic, racial, political, or religious; 2) there was a question of whether this patient had the capacity to make a decision about his health care; and 3) agitated, ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1993Volume 119, Issue 7_Part_1Page: 637-638KeywordsEmotionsForecastingHealth careMotivationPatient advocacy ePublished: 15 August 2000 Issue Published: 1 October 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Proceedings of the Association of American Anatomists.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atmospheric Metal Pollution Monitored by Spherical Moss Bags: A Case Study of Armadale
Authors: Fiona A. Y. Gailey, Owen L. Lloyd
Journal: Environmental Health Perspectives (1986)

To supplement epidemiological investigations into the mortality from respiratory cancer in the small industrial town of Armadale, central Scotland, spherical moss bags were used to study the deposition of atmospheric metal pollution there during a period of 17 months. High concentrations of most metals were found in areas close to the local steel foundry. High concentrations of some metals were also found in the north/northeast of the town. Temporal variations in the metal deposition patterns during the survey-period were observed. By means of statistical analyses, those metals were indicated which were probably emitted from the steel foundry. The scientific and financial advantages of using this method of low technology sampling in epidemiological studies are discussed.
"Increased gastro-oesophageal reflux disease in patients with severe COPD." C. Casanova, J.S. Baudet, M. del Valle Velasco, J.M. Martin, A. Aguirre-Jaime, J. Pablo de Torres, B.R. Celli. * Eur Respir J 2004; 23: 841-845.
Authors: C Casanova, J Baudet, M Del Valle Velasco, J Martin, A Aguirre-Jaime, J Pablo De Torres, B Celli
Journal: European Respiratory Journal (2004)
Acute intermittent porphyria
Authors: G. H. Sack
Journal: JAMA (1990)

<h3>CASE PRESENTATION</h3> Vincent J. Pompili, MD A 24-YEAR-OLD white woman was known to have acute intermittent porphyria (AIP). She completed a normal pregnancy and delivery 16 weeks ago; 14 weeks later, 2 weeks prior to admission to the hospital, she stopped breast-feeding. On the day before admission she had the acute onset of neck, back, and arm pain and weakness. These symptoms worsened over 18 hours, accompanied by nausea, vomiting, and shortness of breath. Breathing became more difficult and respiratory muscle weakness developed. She was intubated, given assisted respiratory ventilation, and admitted to the hospital. Her medical history is notable for three attacks of AIP with abdominal pain and vomiting. She took no medications. There were no known Swedish relatives, but her maternal grandfather, a maternal aunt, and her mother had AIP. On admission she was lethargic but oriented. Her vital signs were as follows: blood pressure, 120/70 mm Hg;
A Multi-Center Randomized Controlled Trial of Intravenous Magnesium for Sickle Cell Pain Crisis in Children
Authors: David C. Brousseau, J. Paul Scott, Oluwakemi Badaki, Deepika S. Darbari, Corrie Chumpitazi, Gladstone E. Airewele, Angela M. Ellison, Kim Smith-Whitley, Prashant Mahajan, Sharada A. Sarnaik, T Charles Casper, Larry J. Cook, Michael Dean, Julie Leonard, Monica L. Hulbert, Elizabeth Powell, Robert I. Liem, Robert Hickey, Lakshmanan Krishnamurti, Cheryl A. Hillery, Julie A. Panepinto
Journal: Blood (2014)
SUNSHINE, SKYSHINE AND RICKETS
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Law and the Modern Mind.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conquering Infertility
Authors: Brian Little
Journal: JAMA (1983)

This short monograph (one hour or so on a sleepless night) is designed for couples with fertility problems. The author, in his introduction, touts this book as a "good start in dealing with fertility." I doubt that's true, but it is a measure of his devotion to the problems of an infertile couple. However, the book is very appropriate for the problem couple who is referred to specialists. Arranged in 17 short chapters, it presents a comprehensive, yet simple, background for understanding complex problems of infertility. It is well thought out and, apart from the somewhat dramatic tone that creeps in from time to time, is bound to be helpful to anyone who can benefit from knowledge of their problem. Corson obviously practices a very good brand of care. The book is recommended for students and patients alike. Obstetricians and gynecologists could also benefit. Corson's encouragement, as described, can bring—as
The relationship between TACC3 expression and chemotherapy resistance in locally advanced rectal cancer patients.
Authors: Rong-xin Zhang, Zhongguo Zhou, Wen-juan Ma, Zhi-zhong Pan, Xiao Jun Wu, Gong Chen, Yang-kui Gu
Journal: Journal of Clinical Oncology (2018)

e15512 Background: Chemoradiotherapy (CRT) and total mesorectal excision (TME) is the standard treatment for locally advanced rectal cancer (LARC) patients. However, not all LARC patients could benefit from CRT. How to identify the most suitable LARC patients for CRT is still a serious issue that needs to be addressed. Methods: 152 LARC patients with pre-treatment tissue reserved enrolled in this study. IHC was conducted to detect the TACC3 expression and evaluated its relationship with the response to chemoradiotherapy, and with the survival outcome. TACC3-siRNA and negative control siRNA were independently transfected into colorectal cells. Cells were divided into four groups to receive different dose of radiotherapy (0Gy, 2Gy, 4Gy and 6Gy). Flow cytometry and CCK8 were performed to detect the cell apoptosis; RT-PCR was deployed to detect the mRNA expression of TACC3; Western blot assay was utilized to measure the protein expression of TACC3. Results: TACC3 expression showed a statistically significant relationship with the pathologic complete response (pCR) rate [risk ratio (RR) = 3.252, 95% confidence interval (CI): 1.918–5.512; P = 0.001] and survival outcome (RR = 3.714, 95% CI = 1.261–10.93; P = 0.017). With the block-down of TACC3, colorectal cells showed more sensitivity to radiotherapy in vitro experiment. Conclusions: TACC3 maybe a predictor for chemoradiotharpy resistance in LARC patients.