tbuckley/cabot-search huggingface dataset:
Hospitals Get Safety Improvement Task List
Authors: B. Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intravenous penicillin.
Authors: H. Smith, S. E. Young
Journal: BMJ (1969)

DIALJOURNAL 53 this association is not clear.The disturbance does not appear to be due to infection or plasma fibrinogen changes as patients with an infection (G, J, M, and P) showed short lysis times, nor did the plasma fibrinogen levels change significantly with changes in lysis time or the occurrence of crises.Bed rest or hospitalization factors did not cause the changes, since, if these were operative, prolonged lysis times would be expected in most hospitalized patients.TABLE II.-LysisTime (Hours) in Control Patients Days of Admission Patient Diagnosis 1 2 3 E Rheumatic arthritis 3-3 10-8 7-2 F Iron deficiency anaemia 24-0 19-3 16-0 G Infective ulcers of toes 0-8 61 4-5 H Iron deficiency anaemia 1-3 5 0 2-9 J Pyogenic abscess of anterior abdominal wall .5-0 45 4.5 K Pain in the neck, cause uncertain . . . .
Bacterial Arthritis
Authors: Don L. Goldenberg, John I. Reed
Journal: New England Journal of Medicine (1985)

BACTERIAL arthritis is a common and serious problem at major urban medical centers. We review the pathophysiology of bacterial arthritis, clinical and microbiologic characteristics of its common forms, and current approaches to diagnosis and treatment of this condition.PathophysiologyBacterial arthritis is usually hematogenously acquired. In 1939 Shaffer and Bennett demonstrated that pneumococcal bacteremia in rabbits often caused pneumococcal arthritis,1 and other laboratory models of bacterial arthritis were subsequently described.2 , 3 The synovium is extremely vascular and contains no limiting basement membrane, thus promoting easy access of blood contents to the synovial space. Certain bacteria, such as Neisseria gonorrhoeae, are . . .
<i>Circulation</i> : Clinical Summaries
Journal: Circulation (2014)

Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial FibrillationAtrial fibrillation (AF) is the most common arrhythmia in clinical practice.There is substantial information available about cellular electrophysiological abnormalities in patients with long-standing persistent AF, but the atrial-cellular pathophysiology in patients with paroxysmal AF (pAF) is largely unknown.Here, we used simultaneous measurements of intracellular [Ca 2+ ] and membrane current/potential in atrial cardiomyocytes from sinus rhythm and pAF patients (last AF episode a median of 10-20 days preoperatively), together with biochemistry and computational modeling, to define the cellular and molecular mechanisms promoting atrial arrhythmogenesis in pAF.L-type Ca 2+ currents and action potential durations were unaltered in pAF patients, indicating the absence of typical AF-associated remodeling.However, cardiomyocytes from pAF patients had enhanced diastolic sarcoplasmic reticulum (SR) Ca 2+ leak and increased susceptibility to spontaneous diastolic SR Ca 2+release events, causing delayed after-depolarizations/triggered activities that promote atrial ectopic (focal) activity.Pharmacological and biochemical studies indicated that the susceptibility to spontaneous cellular activity in pAF was attributable to enhanced SR Ca 2+ uptake, resulting from phospholamban hyperphosphorylation (removing phospholamban-induced inhibition of SR uptake), and ryanodine receptor (SR Ca 2+ release) channel dysregulation, including enhanced ryanodine receptor expression and increased single-channel open probability.Simulation studies indicated that both increased SR Ca 2+ leak and enhanced SR Ca 2+ uptake likely contribute to aberrant diastolic SR Ca 2+-release events.Our findings constitute the first direct evidence for an important role of Ca 2+-dependent ectopic activity in atrial arrhythmogenesis of pAF patients and provide insights into underlying mechanisms.The cellular and molecular mechanisms underlying abnormal Ca 2+ handling in pAF are distinct from those of long-standing persistent AF patients, suggesting possible opportunities to develop tailored therapeutic approaches for pAF.See p 145.
Transactions of the Medical Association of Georgia. 1884.
Authors: None C. E. W.
Journal: JAMA (1885)

This society has succeeded, by inserting a number of advertisements, in getting up its report in very good shape. Among the most interesting matters we note the following: That myopia is increasing among the Southern negroes as a result of book study; that woolen yarn makes an excellent vaginal tampon; that the coloring of urine with hydrochloride of rosaneline facilitates the recognition of pathological elements in the sediment; also, in a paper by Dr. Jas. M. Hale, it is shown that extreme age is no contra-indication for cataract extraction. Dr. Eugene Foster, in a lengthy and able paper, reviews the opinions of Herbert Spencer respecting syphilis as a sociological problem. Spencer claims that the disease in question is on the decrease, both as to the number of its victims and the virulence of the attack. Dr. Foster, like every other thoughtful and observant physician, is fully aware of the error
Reference Committees of the House of Delegates
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alteration in growth regulation of hepatocytes in primary culture obtained from cirrhotic rat: Poor response to transforming growth factor-β1 and interferons
Authors: S Kiso
Journal: Hepatology (1994)

Cell growth appears to be controlled by positive and negative cell growth regulation. Little is known about the growth regulation of hepatocytes in the cirrhotic liver. Clarifying the responses of hepatocytes obtained from cirrhotic liver to various growth factors and growth inhibitory factors might aid understanding of alterations in growth regulation of the hepatocytes in the cirrhotic liver. We investigated the effects of hepatocyte growth factor, epidermal growth factor, heparin-binding epidermal growth factor-like growth factor, transforming growth factor-β1, interferon-α and interferon-γ on the DNA synthesis of hepatocytes from cirrhotic and normal rats in primary culture. Cirrhosis was induced in male Sprague-Dawley rats by means of oral administration of 0.05% thioacetamide in drinking water for 4 mo. Hepatocytes were isolated by means of an in situ perfusion method, and DNA synthesis was assessed from the amount of DNA-incorporated [H]thymidine. Stimulation of the DNA synthesis of hepatocytes by hepatocyte growth factor, epidermal growth factor and heparin-binding epidermal growth factor-like growth factor was not different between normal and cirrhotic rat liver. Transforming growth factor-β1 inhibited the DNA synthesis of hepatocytes in both. However, the concentration of transforming growth factor-β1 giving a 50% inhibition of DNA synthesis was about two times higher in cirrhotic hepatocytes (0.11 ng/ml) than in normal hepatocytes (0.06 ng/ml). In cirrhotic hepatocytes, the expression of transforming growth factor-β type II receptor gene was about 50% of that in normal hepatocytes. The percent inhibitions of DNA synthesis by 1.25 × 104 U/ml of interferon-α were 51.6% ± 3.2% and 14.1% ± 7.7% in normal and cirrhotic hepatocytes, respectively, by 1.25 × 103 U/ml of interferon-γ 44.8% ± 10.3% and 19.9% ± 3.4%, respectively. These results suggest that inhibitory regulation of cell growth may be impaired in the hepatocytes from cirrhotic liver. (Hepatology 1994;20:1303-1308).
Masthead
Authors: Paul Berk, New York, Andres Blei, Henry Bodenheimer, Herbert Bonkovsky, M Worcester, Michael Gerber, New Orleans, Robert Glickman, M Boston, Jay Hoofnagle, Ann Hubbard, Albert Jones, N Francisco, Esteban Mezey, Kunio Okuda, Allan Wolkoff, Lawrence Friedman, T Liang, Irwin Arias, Steven Schenker, Michelle Britton, Debra Segura, Data Meyer, D Montgomery Bissell, Sun Francisco, Anthony Tavill, Eugene Schiff, John Gollan, Joseph Councillors, Neil Bloomer, Los Kaplowitz, C Angeles, Nicholas Larusso, M Rochester, Marion Councillor-At-Large, St Peters, Michael Baltimore, William Lee, Jules Dienstag, Joseph Bloomer, Andrew Klein, Glen Arm, Anna Lok, Kevin Mullen, Robert Cleveland, C S A N Francisco, Adrian Reuben
Journal: Hepatology (1995)
Diagnostic impact of prominent left ventricular trabeculation: Echocardiographic differentiation of secondary hypertrophy vs. dilated cardiomyopathy vs. isolated ventricular non-compaction Philipp A. Kaufmann, Christine Attenhofer-Jost, Erwin Oechslin, Rolf Jenni. Echocardiography, University Hospital, Zurich, Switzerland
Journal: Journal of the American College of Cardiology (2001)
Airborne Concentrations of PM 2.5 and Diesel Exhaust Particles on Harlem Sidewalks: A Community-Based Pilot Study
Authors: Patrick L. Kinney, Maneesha Aggarwal, Mary E. Northridge, Nicole A. H. Janssen, Peggy Shepard
Journal: Environmental Health Perspectives (2000)

Residents ofthe dense urban core neighborhoods of New York City (NYC) have expressed increas- ing concern about the potential human health impacts of diesel vehide emissions.We measured concentrations of particulate matter .2.5 pm in aerodynamic d;ai er (PM2 5) and diesel exhaust particles (DEP) on el in Harlem, NYC, and tested whether spatial variations inl concentra- tions were related to local diese traffic densit Eight-hour (1000-1800 hr) ar: samples for PM2.5 and elemental carbon (EC) .wercolltiied for 5 days in july 1996 on sidewalk adjaent to fur geographicily astinci Harlem interseons.Samples were k u rtable nmoitors worn by study staff.Simltneustrfic cunts for diesel trucks, buses, car,ad pedei were carried out at each intersect.on.. on .. 2 of the 5 sampling days.Eight-hour diesel vehicle COunts ranged from 61: to 2,467 across the four sites.Mean co ntrationso eM25xbited only moest site- to-site variation (3747 pg/m3), reflecting the importance of broader .reionalsourcs of PM2 5.In contrast, EC concentrations vi 4-fold acoss sites (fm 1.5 to 6 p3), and were associated with bus and truck counts on.Ajacent streets and, at.one site, with the presence of a bus depot.A high correlation (r 0 0.95) was observed between EC concentrtions measured analytically and a blackness measurement.basedon PM25 lter reflce, su sg the utility of the latter as a surrogate measre of DEP in e -based studies.These results show that local diesel sources in Hiariem create spatia variaions in sidewalk u mtconcenrions of DEP.The study also demonstrates the feasibility of a new p i for comunity-based researc involving fiu and active pa p betwen ademc scientst and commun-bad orgnations KIy wordr.
Echinacea for the Common Cold
Authors: Seth G. Abrahams
Journal: Annals of Internal Medicine (2003)

Letters7 October 2003Echinacea for the Common ColdSeth G. Abrahams, BCom LLB (Natal), HDip EdSeth G. Abrahams, BCom LLB (Natal), HDip EdFrom Israel.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-7-200310070-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Influenza would have been a better subject for Barrett and colleagues to examine (1). Unfortunately, many manufacturers market echinacea as a preventive agent (2), but this has not been my experience. I have found echinacea drops to be the most effective preparation, but this method of use is unusual and not familiar to many practitioners of traditional medicine. The preparation I use is marketed in Israel as ProtecPlus (Altman Natural Chemist Ltd, Cholon, Israel) and contains additional ingredients besides echinacea. According to instructions, the patient should mix 30 drops with a little water and use it as ...References1. Barrett BP, Brown RL, Locken K, Maberry R, Bobula JA, D'Alessio D. 2002 Treatment of the common cold with unrefined echinacea. A randomized, double-blind, placebocontrolled trial. Ann Intern Med. 137:939-46. [PMID: 12484708] LinkGoogle Scholar2. Vogel A. 1980 Swiss Nature Doctor. A Vogel; 1952 Teufen, Switzerland 335-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Seth G. Abrahams, BCom LLB (Natal), HDip EdAffiliations: From Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTreatment of the Common Cold with Unrefined Echinacea Bruce P. Barrett , Roger L. Brown , Kristin Locken , Rob Maberry , James A. Bobula , and Donn D'Alessio Echinacea for the Common Cold Wendy L. Applequist Echinacea for the Common Cold Steve Shober Echinacea for the Common Cold Paul Mittman , Debra Wollner , and Linda Kim Echinacea for the Common Cold Paul J. Millea Echinacea for the Common Cold Bruce Barrett Echinacea for the Common Cold Ethan B. Russo Metrics Cited byAn Evidence-Based Systematic Review of Echinacea ( E. angustifolia DC, E. pallida, E. purpurea ) by the Natural Standard Research Collaboration 7 October 2003Volume 139, Issue 7 Page: 599 Keywords Cells Common cold Enzymes Food Immune system Liver Mouth Mucous membranes Proteins Traditional medicine ePublished: 7 October 2003 Issue Published: 7 October 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Medicare Showdown
Authors: John K. Iglehart
Journal: New England Journal of Medicine (2008)

In a stunning rebuke of President George W. Bush, the House and Senate voted July 15 in a strong bipartisan fashion to override a veto he had issued only hours earlier, erasing a scheduled reduction of 10.6% in the fees that Medicare pays physicians. At the risk of alienating the nation's doctors, Bush had vetoed the measure because he strongly objected to the way in which it covered the costs of eliminating the fee reduction: by cutting payments to private Medicare Advantage plans that contract with the Centers for Medicare and Medicaid Services to provide coverage to Medicare beneficiaries. The . . .
THE TREATMENT OF THE TOXEMIA OF EARLY AND LATE PREGNANCY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poverty is a political choice
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2018)

In the UK, "poverty is a political choice. Austerity could easily have spared the poor, if the political will had existed to do so." This is the conclusion of the damning statement released on Nov 16, 2018, by the UN Special Rapporteur on Extreme Poverty and Human Rights, Prof Philip Alston. Given that the UK is the world's fifth largest economy, "it thus seems patently unjust and contrary to British values that so many people are living in poverty".
Current Medical Education Opportunities for Physicians
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Changes during Mouse Skin Tumorigenesis
Authors: Philip A. Burns, Rod Bremner, Allan Balmain
Journal: Environmental Health Perspectives (1991)

This paper describes specific genetic changes involving chromosome 7 in mouse skin tumors, the most important consequence of which appears to be an alteration in the allelic balance of normal and mutant H-ras genes. The use of restriction-fragment-length polymorphisms in F1 hybrid mice demonstrates that trisomy of chromosome 7 is an early event preceding papilloma formation, and further events, such as mitotic recombination, seem to occur during progression to malignant carcinomas. There is some evidence of a tumor-suppressor locus situated on chromosome 7.
Increased signals seen in globus pallidus in tl-weighted magnetic resonance imaging in cirrhotics are not suggestive of chronic hepatic encephalopathy
Authors: P THULUVATH
Journal: Hepatology (1995)

Increased, symmetrical signals of varying intensity in the globus pallidi on T1-weighted (T1W) images, without corresponding signals on T2-weighted (T2W) images, have been reported previously in chronic hepatic failure. It has been suggested that these signals are characteristic of chronic hepatic encephalopathy. To test this hypothesis, we evaluated the relationship of magnetic resonance imaging (MRI) abnormalities with ammonia, albumin, bilirubin, prothrombin time, ascites, clinical encephalopathy, and neuropsychological tests in 46 patients (16 with alcohol-induced cirrhosis and 30 with non-alcohol-induced cirrhosis). T1W signal and cortical atrophy were graded by a neuroradiologist in a blinded fashion. Eleven patients had no T1W signal, 18 had minimal T1W signal, and 17 had high T1W signal. Twenty-five patients had no cortical atrophy, 14 had mild atrophy, and 7 had moderate atrophy. Cortical atrophy was noted more commonly in patients with alcohol-induced liver disease. The neuropsychological tests correlated significantly with albumin, prothrombin time, Child-Pugh's score, clinical encephalopathy, and ammonia. T1W signal and cortical atrophy did not correlate with the neuropsychological tests, clinical encephalopathy, ascites, albumin, prothrombin time, ammonia, or Child-Pugh's score. Patients with high T1W signal showed significant correlation with bilirubin (P < .005). This study suggests that globus pallidus signal in T1W images observed in liver disease are not indicators of chronic hepatic encephalopathy as previously assumed.
INFECTIOUS SYPHILIS
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Community-oriented primary care
Authors: D. E. Rogers
Journal: JAMA (1982)

COMMUNITY-ORIENTED care programs are a rational way to deliver the fruits of biomedical and behavioral scientific knowledge effectively to those who need them. No thoughtful person can argue with the logic of this approach. How can one believe that improvements in health can occur without thorough epidemiologic knowledge of health problems that exist in a community or a society? How can preventive, rehabilitative, or curative services be fully effective if one knows little or nothing about the cultural, educational, economic, or psychological factors that can create barriers to care, isolate groups, and increase personal health risks for community inhabitants? No one in modern society can believe that a physician working in isolation, and simply treating those who come to him on a one-on-one basis, can produce a healthy society. If this is the case, why can I as an "outsider" ask the following questions: Why hasn't community-oriented primary care (COPC)