tbuckley/cabot-search huggingface dataset:
The Self-reporting of Cocaine Use
Authors: JudyAnn Bigby
Journal: JAMA (1992)

<h3>To the Editor.</h3> —We are disturbed about several aspects of the study of cocaine use and self-report recently published in<i>JAMA</i>.<sup>1</sup> We disagree with the authors' statement that the study situation replicates a patient-physician interaction. The interaction lacked personal physician-patient contact and an explanation about why the questions on drug use were relevant to the study on STDs and the presenting complaints. Patients had no reason to believe that the question about cocaine use was relevant to their clinical problem or to the STD study in which they consented to participate by submitting a urine sample. Since cocaine use is illegal, the study population could not be sure how an admission of cocaine use might affect their clinical care. The authors conclude that self-report of cocaine use is unreliable. However, the interaction specifically does not replicate the appropriate way to obtain a substance abuse history since questions about quantity
Treatment of Neoplasias with New Trisethylene-Imino-Benzoquinone Derivative
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mercury in Human Hair Due to Environment and Diet: A Review
Authors: D. Airey
Journal: Environmental Health Perspectives (1983)

Hair mercury levels increase with the amount of fish in the diet and the amount of mercury in the fish species consumed. If hair mercury levels in people throughout the world were monitored by a standard analytical procedure, the results would indicate locations where people's body burden of mercury is high enough to be subclinically unhealthy and where controls on environmental emissions might be beneficial. The relationship of hair mercury concentration to the method of sampling and analysis of hair, the analysis of the results, the amount of fish consumed, the country and location from which samples were taken and the age, sex and occupation of the donor is discussed.
Substaging cancers gives treatment flexibility
Authors: W. A. Check
Journal: JAMA (1979)

One of the most puzzling questions in cancer treatment is why patients with tumors of apparently similar type and stage don't all respond to the same treatment. In two separate studies investigators have now discovered (1) clues in biopsy specimens that may predict which women with stage I breast cancer are most likely to have recurrences after surgery and (2) which patients with invasive bladder cancer are most likely to benefit from preoperative radiation therapy. If the findings hold up, they could prove valuable in helping physicians decide which patients need the most aggressive treatment and in the design of therapeutic trials to discover more effective therapies. Analysis of patients with breast cancer was done by Thomas Nealon, MD, director of surgery at Saint Vincent's Hospital in New York City and professor of surgery at the New York University School of Medicine, and John Gilloolley, MD, director of pathology at
Herbal<i>PDR</i>
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0084 Novel regulation of TNF-α-induced-IL-18 bioactivity in rheumatoid arthritis synovial fibroblasts by reducing caspase-1 via JAK2 inhibition
Authors: H. Marotte, T. Fedorova, A.J. Pinney, B. Lewis, A.E. Koch
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is the most common inflammatory chronic joint disorder. Interleukin-1 (IL-1) family members play a key part in the pathogenesis of RA. Among the IL-1 cytokine family members, IL-18 is a proinflammatory cytokine, which modulates Th1 development and induces angiogenesis. We previously described regulation of TNF-α-induced-IL-18 bioactivity by blocking the ERK pathway. Here, we focused on modulation of TNF-α-induced-IL-18 bioactivity by reduction of caspase-1 expression. <h3>Methods</h3> Caspase-1 expression in RA synovial fibroblasts treated with TNF-α was assessed by qRT-PCR and Western blot. The critical pathways for TNF-α-induced caspase-1 expression were determined by using chemical inhibitors: pyrrolidine dithiocarbamate (PDTC; a nuclear factor kappa-light-chain-enhancer of activated B cells [NFκB] inhibitor; 200μM), MAPK inhibitors (ERK1/2, PD98059; p38, SB202190; or JNK2, SP600125; 10μM), or AG-490 (a JAK2 inhibitor; 10 μM) followed by TNF-α stimulation. Caspase-1 expression was determined by qRT-PCR and Western blot. Immunofluorescence (IF) staining was performed to check IL-18 production induced by TNF-α with or without preinhibition of ERK1/2 or JAK2 by using antibody recognized immature and mature IL-18. IL-18 level was also assessed by ELISA in cell lysates and concentrated culture supernatants. IL-18 functional activity was assessed using an IL-18 bioactivity assay using KG-1 cells and culture supernatants. <h3>Results</h3> TNF-α induced RA synovial fibroblast caspase-1 expression at the mRNA and protein levels in a time-dependant manner (P&lt;0.05; n≥6 patients). Blocking the JAK2 pathway reduced TNF-α-induced-caspase-1 expression at the transcriptional and protein level by approximately 60% and 40%, respectively (P&lt;0.05; n≥4). Blocking NFκB, ERK1/2, JNK or p38 pathways had no effect on TNF-α-induced-caspase-1 mRNA expression. We then confirmed by IF that TNF-α-induced IL-18 and investigated roles of ERK1/2 and JAK2 pathways. Blocking the ERK1/2 pathway dramatically decreased IL-18 expression induced by TNF-α. However, when blocking the JAK2 pathway, TNF-α induced intracytoplasmic granular IL-18 expression, suggesting a defect of caspase-1. Blocking JAK2 pathway increased intracellular TNF-α-induced IL-18 level, but reduced extracellular TNF-α-induced IL-18 level in concentrated supernatant assessed by ELISA. Finally, blocking the JAK2 pathway, we observed a reduction of IL-18 bioactivity by 52% in RA synovial fibroblasts. <h3>Conclusions</h3> These results show a unique way to block TNF-α-induced-IL-18 bioactivity by blocking capase-1. These data provide a novel role for the JAK2 pathway in RA patients and emphasize the use of JAK inhibitors as a new therapeutic option in the management of RA. <h3>Disclosure of Interest</h3> None Declared
Perforin-Mediated Target Cell Lysis By Cytolytic Lymphocyte T
Authors: J Tschopp
Journal: Annual Review of Immunology (1990)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Dumping
Authors: Cory Franklin
Journal: JAMA (1987)

<h3>To the Editor.—</h3> As one charged with the responsibility of devising and implementing a new policy at Cook County Hospital, Chicago, for the transfer of patients from other hospitals, I feel compelled to add additional information to the present debate. In their original article<sup>1</sup>and policy article,<sup>2</sup>Drs Ansell and Schiff outlined the negative consequences for patients transferred to Cook County Hospital from other hospitals. What was not mentioned in either article were the following facts: At the time of the study, Cook County Hospital had no formal mechanism for accepting patients from other hospitals. Attending and senior physicians were not assigned the responsibility of accepting patients, this often being delegated to inexperienced staff. Little or no attempt was made to screen seriously ill transfers from those who might not even require admission. Often no special provisions were made for patients seriously ill during transport.
Author Name Misspelled in: Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock
Authors: Jeffrey Williams, Rachel Werner, L Goldman, R Dudley
Journal: JAMA (2008)

cian shortage over the next several decades will strain community hospitals' workforces.Rather than try to increase graduate medical education funding to large training programs, perhaps ways to create and expand community hospital training programs should be explored.
Hepatic involvement in mastocytosis: Clinicopathologic correlations in 41 cases
Authors: Joann M. Mican, Adrian M. Di Bisceglie, Tse-Ling Fong, William D. Travis, David E. Kleiner, Bennie Baker, Dean D. Metcalfe
Journal: Hepatology (1995)

Mastocytosis is a disease of mast cell hyperplasia that may involve several organ systems, including liver. Between 1988 and 1991, we conducted a retrospective-prospective study of 41 patients with mastocytosis and found 61% had evidence of liver disease. Hepatomegaly was detected in 24%, splenomegaly in 41%, and elevated serum alkaline phosphatase, serum aminotransaminases, 5′nucleotidase, or gamma-glutamyltranspepti-dase (GGTP) in 54% of the patients. Alkaline phosphatase levels directly correlated with GGTP levels, hepatomegaly, splenomegaly, and liver mast cell infiltration and fibrosis. Elevated alkaline phosphatase levels and splenomegaly were observed more frequently in patients with categories II and III mastocytosis. Five patients in combined disease categories II or III developed ascites or portal hypertension and died of complications of mastocytosis; three had hypoprothrombinemia at the time of death. Thirty-five liver biopsy specimens from 25 patients were examined. Mast cell infiltration was commonly observed in the biopsy specimens, more severe in those patients with either category II or III disease, and correlated with hepatomegaly, splenomegaly, alkaline phosphatase levels, and GGTP levels. Mast cells were often only detected by using special stains (tolu-idine blue and chloracetate esterase). Increased portal fibrosis was seen in 68% of the biopsy specimens and correlated with mast cell infiltration and portal inflammation. Cirrhosis was not observed. Nodular regenerative hyperplasia, portal venopathy, and venoocclusive disease was observed in eight biopsy specimens and may have been the cause of the portal hypertension or ascites in four patients. These findings demonstrate that liver disease with mast cell infiltration is a common finding in patients with mastocytosis. Severe liver disease, however, is uncommon except in patients with mastocytosis who are in categories II and III, where it may contribute to both morbidity and mortality. (Hepatology 1995; 22:1163-1170.).
The febrile response in acute otitis media
Authors: R. H. Schwartz
Journal: JAMA (1981)

Of 671 children with acute otitis media seen in our private practice, only 23% had fever. Very high fever (≥40.5 °C) was noted in only two children. In only 4% of the 671 children did the fever last more than 48 hours after antibiotic treatment had been started. We found that the organism causing the acute otitis media was unrelated to the presence of fever associated with this illness. (<i>JAMA</i>1981;245:2057-2058)
The Bereft. A Series of Asylum Romances.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE HOODOOED TEXAS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiation Oncology
Authors: James D. Cox
Journal: JAMA (1991)

The centennials of the discoveries of radioactivity, x-rays, and radium will soon be celebrated. Over these 100 years, radiation therapy has come to occupy an important position in the cure and palliation of over half the more than 1 million patients who are found to have cancer each year in the United States. Recent reports of large clinical studies have demonstrated the dependence of long-term survival on control of the local-regional tumor in adenocarcinoma of the prostate<sup>1</sup>and squamous cell carcinoma of the upper aerodigestive tract.<sup>2</sup>In addition, cure of most patients with initially localized carcinomas of the cervix, rectum, bladder, and brain depends on successful control of the primary tumor and regional lymphatic metastasis. This need for regional control provides new impetus to the search for ways to enhance radiation effects. One approach is to enlarge the area irradiated. For example, in invasive cancer of the cervix,
Hernia and Hernioplasty.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Reference Citations
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Forced expiratory indices in normal black Southern African children aged 6-19 years
Journal: Thorax (1991)

Forced expiratory indices in normal black Southern African children aged 6-19 years In the paper by Dr M H Shamssain (March 1991;46:175-9) "log" should be added to the equations in the legends to the four figures on pages 177 and 178-before "FVC" in figures 1 and 2 and before "FEV," in figures 3 and 4. For convenience the figures and the legends with the corrected equations are reproduced here.
Persistence of Long, Thin Chrysotile Asbestos Fibers in the Lungs of Rats
Authors: Patrick G. Coin, Victor L. Roggli, Arnold R. Brody
Journal: Environmental Health Perspectives (1994)

The distribution of inhaled mineral fibers in the lung determines the site and severity of disease caused by the fibers.Some of our recent work has described the fate of inhaled asbestos fibers in rodents.After a brief inhalation exposure, asbestos fibers are deposited primarily at the first alveolar duct bifurcations, and fibrotic lesions are initiated.These sites of deposition occur as close to the visceral pleura as 220 pm.Several studies have suggested that short fibers are cleared from the lung more efficiently than long ones, and our data support this view.Our laboratory has shown that aerosolized chrysotile fibers longer than 16 pm can be deposited in the peripheral lung parenchyma of rats, and the measured clearance rate of these fibers is not significantly different from zero.Chrysotile, but not amphibole, fibers split longitudinally, so that the number of retained chrysotile fibers .16pm in length increases over time.We have not observed significant changes in chemical composition of chrysotile fibers up to 30 days post-deposition in the rat.Nor have we observed translocation of chrysotile fibers from the "central" regions of the lung toward the subpleural regions.However, 1 month after a single 3-hr exposure to chrysotile asbestos, the longest, most pathogenic fibers persist throughout the lung parenchyma.These retained fibers have the potential to cause disease in both parenchyma and pleura.
Neurontransmitter Transporters: Recent Progress
Authors: K. Susan G. Amara and Michael J.
Journal: Annual Review of Neuroscience (1993)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Dicumarol Is Not Dicurin Procaine
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal