tbuckley/cabot-search huggingface dataset:
Propylthiouracial in Hemorrhagic Pancreatitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Absorption and metabolism of levodopa
Authors: W. B. Abrams
Journal: JAMA (1971)

Although levodopa is a natural body substance, it is also a new drug, and as such, information is needed on the extent and rate of absorption, the distribution in the body, and the mechanisms and rate of elimination. Furthermore, the desired actions in the brain and the central and peripheral side effects appear to be due to one or more biotransformation products rather than to levodopa itself. The current hypothesis of the mechanism of action of levodopa holds that parkinsonism is due to a deficiency of the dopaminergic neurones in the substantia nigra which terminate in the corpus striatum.<sup>1</sup>Dopamine itself cannot be used in treatment because of its inability to cross the blood-brain barrier. However, levodopa, an amino acid, enters the brain and is readily decarboxylated to dopamine. Thus, the metabolism of levodopa is of great clinical significance. In our laboratories, absorption and metabolism studies have been conducted
Structure-Induction versus Structure-Toxicity Relationships for Polychlorinated Biphenyls and Related Aromatic Hydrocarbons
Authors: J. D. McKinney, K. Chae, E. E. McConnell, L. S. Birnbaum
Journal: Environmental Health Perspectives (1985)

A comparison of the structure-induction (involving rat and mouse Ah receptor binding) and structure-toxicity (in vivo guinea pig toxicity) relationships suggests that two receptors with structurally distinct binding properties may be involved. This is supported by demonstration of potentiated toxicity through a mechanism believed to involve the Ah receptor as a site of loss with respect to toxicity. Theoretical and working models are proposed for these separate receptors to aid in the search for other relevant binding proteins. The findings suggest that polychlorinated biphenyls that are relatively low in toxicity may have modulating properties on the action of highly toxic compounds with which they are normally found in the environment.
Student's Manual of Electro-Therapeutics.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Drinking drivers and the law.
Journal: BMJ (1976)

Drinking drivers and the lawThe introduction in 1967 of an offence based on a statutory blood alcohol concentration, associated with a screening breath test, led to a dramatic reduction in road accident mortality and morbidity.Over 1000 lives were saved in the first year after the Act' and an estimated total of 4000 in subsequent years.But the rate of casualty savings fell off progressively, and there are now bleak indications that the problem of drinking and driving is worse than ever.Before the Act about 25% of drivers killed in accidents were found to have had concentrations above the statutory 80 mg 100 ml limit.That proportion was reduced to
Lymphocytic choriomeningitis outbreak associated with pet hamsters. Fifty-seven cases from New York State;
Authors: R. J. Biggar
Journal: JAMA (1975)

An outbreak of lymphocytic choriomeningitis (LCM) associated with pet hamsters acquired through a nationwide distributor was recognized in New York in February 1974. In upstate New York, 57 cases occurred in a four-month period. Complete information was obtained on 49 patients ranging in age from 3 to 70 years. Characteristic findings included fever (90%), headache (85%), and severe myalgia (80%). Typically, laboratory findings consisted of a normal blood cell count and cerebrospinal fluid with mononuclear leukocyte pleocytosis and moderate hypoglycorrhachia. All patients had contact with hamsters from one distributor. Most of the hamsters were acquired in mid to late December 1973, but some as late as March 1974. From each of eight families in which hamsters were available, at least one hamster had detectable complement-fixing antibodies for LCM. Infection rates within families varied with location and type of hamster cage; open cages and cages situated in common living areas were associated with highest infection rates (45% and 52%, respectively). Severity of illness was not associated with direct contact with hamsters. Onset of illness occurred between 8 and 90 days after initial exposure to hamsters. (<i>JAMA</i>232:494-500, 1975)
Abstract 4948: T helper 2 cells block breast cancer promotion
Authors: Margherita Boieri, Anna Malishkevich, Lauren Steidl, Kenneth Ngo, Sowmya Iyer, Mary Awad, Johannes Kreuzer, Wilhelm Haas, Miguel Rivera, Shadmehr Demehri
Journal: Cancer Research (2019)

Abstract New immune-based strategies for cancer treatment including the activation of tumor-infiltrating CD8+ cytotoxic T lymphocytes (CTLs) have led to effective therapeutics against late-stage disease. However, the function of the immune system in combating the early-stage cancers remains uncertain. To establish a mechanism that activates immune cells against early carcinogenesis, we have studied the role of an epithelial-derived cytokine, thymic stromal lymphopoietin (TSLP), in early stages of breast cancer development. We have previously discovered that TSLP blocks breast carcinogenesis through the activation of CD4+ T cells that heavily infiltrate the sites of developing cancer in the breast gland without affecting the normal tissue.To investigate the mechanism by which TSLP-stimulated CD4+ T cells suppress spontaneous breast cancer development, we used MMTV-PyMT transgenic mouse models (PyMTtg) that spontaneously develop breast tumors and resemble the human luminal breast cancer. These mice were crossed into TSLP transgenic mice that produce TSLP under the promoter of a skin-specific keratin 14 promoter (K14-TSLPtg), plus additional knockouts including TSLPR-/- and IL4rα;-/-. Tumor development was arrested in K14-TSLPtg;PyMTtg mice compared to PyMTtg counterparts as their tumors failed to progress to high grade. The tumor suppressive mechanism of CD4+ T cells was mediated by a block in cancer cell proliferation, but not by cytotoxicity. Polarization of CD4+ T cells into T helper 2 (Th2) subtype was essential for blocking breast tumor development, and the tumor suppression was achieved by CD4+ T cells in the absence of CD8+ T and B cells. Finally, we found the basal levels of TSLP released by premalignant breast epithelial cells to be protective against the early phases of breast cancer development.In conclusion, we demonstrate that CD4+ Th2 cells block early stages of breast carcinogenesis. TSLP stimulated CD4+ Th2 cells induce an arrest in cancer cell proliferation, which represents a novel mode of immunity with great potential for the prevention and treatment of breast cancer. Citation Format: Margherita Boieri, Anna Malishkevich, Lauren Steidl, Kenneth Ngo, Sowmya Iyer, Mary Awad, Johannes Kreuzer, Wilhelm Haas, Miguel Rivera, Shadmehr Demehri. T helper 2 cells block breast cancer promotion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4948.
Health policy agenda for the American people
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Potentially Ineffective Care
Authors: Laura Esserman, Jeffrey Belkora, Leslie Lenert
Journal: JAMA (1995)

<h3>Objective.</h3> —To examine the limits of the effectiveness of critical care through the study of patients for whom it was ineffective. <h3>Design.</h3> —We studied the relationship between resource use and long-term outcome (2-year follow-up) in 402 consecutively admitted critical care patients to develop a benchmark for ineffective applications of critical care. We defined an outcome called potentially ineffective care (PIC), developed and evaluated a model with an independent data set to predict PIC from a patient's response to treatment, and estimated the economic effects of limiting care after a prediction of PIC. <h3>Setting.</h3> —The combined medical and surgical intensive care unit at a 600-bed university teaching hospital. <h3>Patients.</h3> —Two groups of 402 consecutively admitted critical care patients, one from 1989, the other from 1991. <h3>Main Outcome Measures and Results.</h3> —Based on observations from a two-dimensional plot of resource use vs benefit for 402 critical care patients, PIC was defined as resource use in the upper 25th percentile and survival for less than 100 days after discharge. Thirteen percent of the patients fell into the PIC category and used 32% of the resources. A product of the APACHE risk estimates on days 1 and 5 of at least 0.35 predicted 37% of PIC outcomes with a specificity of 98%. In a second data set, PIC outcome prediction had a sensitivity of 43% and a specificity of 94%, and a positive predictive value of 80%. For the hospital studied, reduction of intensity of treatment after a prediction of a PIC outcome would result in a reduction of hospital charges in the range of $1.8 million to $5 million per year. <h3>Conclusion.</h3> —Patients in the PIC category consumed a large portion of the resources devoted to critical care at an academic teaching hospital. We suggest a change in focus from assessment of the quality of critical care and risk-adjusted mortality to an assessment of ineffective care based on outcome and resource use and a patient's response to treatment over time. (<i>JAMA</i>. 1995;274:1544-1551)
Carotid sinus syncope. Report of two cases
Authors: A. L. Chughtai
Journal: JAMA (1977)

In two cases of hyperactive carotid sinus with syncope, both patients had a history of syncopal attacks. Carotid sinus massage produced asystole lasting for four seconds with recurrent symptoms. Permanent demand pacemakers were implanted in both patients, causing a relief of symptoms. (<i>JAMA</i>237:2320-2321, 1977)
IMPORTANCE OF THE VITAL CAPACITY IN THORACIC SURGERY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reports
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Spinal Anesthesia . By Charles H. Evans. M.D., Clinical Assistant, New York Post-Graduate Medical School and Hospital; Lying-in Hospital of the City of New York; Assistant Surgeon, New Jersey Orthopedic Hospital, Orange. Published by Paul B. Hoeber, Inc., New York. January, 1929. 203 pages. Price $5.50.
Journal: New England Journal of Medicine (1929)
US Forensic Pathologists on a New Case: Examination of Living Persons
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CONTAGION FROM RETURNED BOTTLES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of magnesium on blood pressure
Authors: T. Dyckner, P O Wester
Journal: BMJ (1983)

From my previous observations in Nigeria, I concur with the conclusions reached by the authors that there is no clear evidence of a relation between stillbirth and preterm birth in west Africa.I am puzzled by the complete absence of malaria parasites in placental smears examined by the authors, since in my experi- ence, and that of many other workers, Plas- modium falciparum can be easily stained and seen, as late trophozoites and fully grown schizonts, mainly in the intervillous spaces of the placenta near the stratum spongiosum.6The presence of pigment may be an acceptable indicator of the previous infection, but only an indirect one.One might assume that the treatment received in the antenatal clinic was so thorough that the placental infection was rapidly eliminated, but this is contradicted by the incidence of peripheral parasitaemia in primigravidas and the author's own comment on the limited effectiveness of the curative service.Finally, I am in complete agreement with the authors that pregnant women in endemic malarial areas of Africa should receive full curative treatment in the presence of falciparum parasitaemia and adequate chemo- prophylaxis throughout the last three months of pregnancy.
Spinal cord involvement in acute bacterial meningitis
Authors: G. G. Glista
Journal: JAMA (1980)

A 25-month-old boy had the development of respiratory arrest and quadriplegia with a T-10 sensory level during the acute phase of<i>Haemophilus influenzae</i>meningitis. The sequelae of spinal cord involvement of bacterial meningitis are reviewed. A possible mechanism of the spinal cord involvement in this case is discussed with reference to known pathology of<i>H influenzae</i>meningitis. (<i>JAMA</i>243:1362-1363, 1980)
Novel In Situ Gelling Hydrogels Loaded with Recombinant Collagen Peptide Microspheres as a Slow-Release System Induce Ectopic Bone Formation
Authors: Shorouk Fahmy‐Garcia, Didem Mumcuoglu, Laura de Miguel, Veerle Dieleman, Janneke Witte‐Bouma, Bram C. J. van der Eerden, Marjolein van Driel, David Eglin, Jan A. N. Verhaar, Sebastiaan G. J. M. Kluijtmans, Gerjo J. V. M. van Osch, Eric Farrell
Journal: Advanced Healthcare Materials (2018)

Adv. Healthcare Mater. 2018, 7, 1800507 In the Experimental Section of this article, the chemical HMDIC was incorrectly named as hexamethylene diisocyanide. The correct chemical name is as follows: Hexamethylene diisocyanate (HMDIC). This was a typographical error and does not affect the results of the work.
Therapeutic radiology
Authors: J. A. del Regato
Journal: JAMA (1980)

The remarkable technological development of computerized tomography has proved extremely beneficial to the practice of therapeutic radiology. It has refined the radiological examination of laryngeal as well as deep-seated tumors, but, in addition, it has become an excellent means of assessing tumor volume and boundaries, allowing reduction in the area of tissue to be irradiated. Radiation oncology has also benefited from nuclear scanning, permitting the identification of primary and secondary tumor foci with radioactive materials. The adoption of computerized dosimetry in the everyday practice of radiotherapy permits the study of safe distribution of radiation throughout the area of tumor involvement. <h3>New Sources of Radiation</h3> Once possessed exclusively by research institutions, megavoltage generators of photons, ranging from 4 to 25 million volts, have now become conventional in hospitals and radiation centers everywhere. Low-energy electrons have been used for some time, but high-energy electrons are now available for clinical use in radiation