tbuckley/cabot-search huggingface dataset:
THE STRIKE FEVER.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detaining patients with AIDS.
Journal: BMJ (1985)

Recent British statutory regulations classify acquired immunodeficiency syndrome (AIDS) as a notifiable disease for the following purposes: compulsory medical examination, compulsory removal to hospital, compulsory detention of hospitalized patient, restrictions on the removal of the body of a person dying in hospital, and the isolation of the body of a person dying outside a hospital. On 14 September a 29-year-old male with AIDS was legally prevented from leaving a hospital; the order was later overturned on appeal. The 1985 regulations extend the restrictive authority of the magistrate, in the case of AIDS only, to situations where the person would not take proper precautions to prevent the spread of the disease. They do not make AIDS a notifiable disease in relation to school attendance.
Trends in Childhood Cancer Mortality—United States, 1990-2004
Journal: JAMA (2008)

Cancer is the fourth most common cause of death (after unintentional injury, homicide, and suicide) among persons aged 1-19 years in the United States. Because recent childhood cancer mortality has not been well characterized in terms of temporal, demographic, and geographic trends, CDC analyzed cancer death rates among children (defined as aged 0-14 years) and adolescents (defined as aged 15-19 years) for the period 1990-2004 by sex, age group, race, ethnicity, U.S. Census region, and primary cancer site/leading diagnosis, using the most recent data available from the National Vital Statistics System (NVSS). This report describes the results of that analysis, which indicated that, overall, age-adjusted childhood cancer death rates decreased significantly during 1990-2004 among both sexes, both age groups, all races (except American Indians/Alaska Natives [AI/ANs]), Hispanics, non-Hispanics, and all U.S. Census regions. However, decreases in death rates varied among U.S. Census regions and between Hispanics and non-Hispanics. Eliminating racial/ethnic health disparities is one of the overarching goals of Healthy People 2010. Further research is needed to understand geographic and ethnic disparities in childhood cancer death rates. Moreover, cancer prevention and intervention measures should be designed to reach populations that are underserved and at high risk.
Emergency Contraception
Authors: Douglas P. Miller
Journal: Annals of Internal Medicine (2003)

Letters4 February 2003Emergency ContraceptionDouglas P. Miller, MDDouglas P. Miller, MDCatawba Memorial Medical Center; Hickory, NC 28601 (Miller)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-3-200302040-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their review on emergency contraception (1), Grimes and Raymond claim that emergency postcoital contraception is fundamentally different from early abortion of an established pregnancy. In so doing, they have created a distinction without a difference.Hormonally mediated contraception, whether pre- or postcoital, is well recognized as having a dual mechanism of action. Sometimes conception itself is prevented and sometimes implantation of an already conceived embryo is prevented, thus precipitating an early abortion. The use of the term abortion is appropriate for this type of procedure because a human embryo is genetically a distinct individual from the ...Reference1. Grimes DA, Raymond EG. Emergency contraception. Ann Intern Med. 2002;137:180-9. [PMID: 12160366] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Catawba Memorial Medical Center; Hickory, NC 28601 (Miller) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEmergency Contraception David A. Grimes and Elizabeth G. Raymond Emergency Contraception David A. Grimes and Elizabeth G. Raymond Metrics 4 February 2003Volume 138, Issue 3Page: 237-238KeywordsContraceptivesEmbryosGeneticsNutritionPregnancy ePublished: 4 February 2003 Issue Published: 4 February 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ovarian Cancer
Authors: H. R. K. Barber
Journal: CA A Cancer Journal for Clinicians (1986)

Early diagnosis is the most effective means of reducing the currently high mortality rate associated with ovarian cancer. The palpation of what appears to be a normal size ovary in a premenopausal woman suggests an ovarian tumor in a postmenopausal woman. Ovarian cancer should be ruled out in any woman 40 years of age or older who has persistent, unexplained GI symptoms. Ninety percent of all ovarian tumors are of epithelial origin. Treatment consists of total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and appendectomy. Instillation of P32 is optional. In stages IIb, III, and IV tumors, chemotherapy is advised; in stages I and IIa, the use of prophylactic chemotherapy must be judged on an individual basis. In children, ovarian cancer that is beyond the localized stage is one of the most frustrating of all gynecologic diseases. Total surgical extirpation of disease is the only hope for cure; for now, early diagnosis is more chance than scientific method. Thanks to better public and professional education, ovarian cancer is now being diagnosed at an earlier stage. The earlier the diagnosis, the greater the chance for cure. It is becoming obvious that ovarian cancer is a disease of the GI tract, and physicians treating ovarian cancer should be prepared to deal with bowel-associated problems. The practice of tapping women with ascites for diagnosis as well as doing an exploration merely to obtain a biopsy should be discouraged. Unless the physician is prepared to carry out the optimal surgical approach for the patient, it is crucial that the patient be referred to either a center or to a physician who is actively engaged in the day-to-day care of cancer patients. With the combined use of all the available treatment methods, patients with ovarian cancer are now living longer and more comfortably. There is also indication that their long-term survival will be increased. The one message that is important for both patients and physicians is that the gloom and doom of the 1960s and 1970s can now be replaced by a spirit of optimism.
Mercy—for the Terminally III Cancer Patient!
Authors: John A. Beall
Journal: JAMA (1983)

My daughter, whom I shall identify as J.A., finally succumbed to disseminated metastatic carcinoma of the breast during the spring of 1982 at the age of 34 years. Her prolonged suffering occasioned the writing of this article. I hope that her abridged case history will help to somehow temper the overaggressive treatment of the obviously and hopelessly ill terminal cancer patient by both academic and grass roots physicians. This is a voice from the country speaking its piece. Unless a physician has had the misfortune of having a loved one die by inches as he stands helplessly by, he would have difficulty gaining this insight necessary to understand suffering and its iatrogenic prolongations. Most physicians caring for very ill patients make their decisions on brief, no matter how compassionate, visitations. The hour-by-hour, day-by-day vigil is left to the nursing staff and the family. The treatment plan is outlined by the
Myocarditis associated with methyldopa therapy
Authors: F. G. Mullick
Journal: JAMA (1977)

Five patients with hypertension died as a result of myocarditis. Three were treated with methyldopa and hydrochlorothiazide, two with methyldopa alone. Their ages ranged from 30 to 71 years. In all instances death occurred suddenly, and myocarditis was not suspected clinically. The inflammatory changes in the hearts of these patients were most consistent with a hypersensitivity reaction. Additionally, there was hepatitis consistent with hypersensitivity in four of the cases. (<i>JAMA</i>237:1699-1701, 1977)
Linking Environmental Agents and Autoimmune Disease: An Agenda for Future Research
Authors: MaryJane K. Selgrade, Glinda S. Cooper, Dori R. Germolec, Jerrold J. Heindel
Journal: Environmental Health Perspectives (1999)

1-3 September 1998, to review current knowledge about links between environmental exposures and autoimmune disease, to identify and prioritize research needs, and to develop an integrated, multidisciplinary research agenda.Participatants spent the last half-day of the workshop in small group discussions for the purpose of developing consensus on research needs.Research needs identified were a) develop research tools needed to explore links between environmental agents and autoimmune disease; b) establish a disease registry or surveillance system; c) develop and validate strategies for screening chemicals for the potential to induce or exacerbate autoimmune disease; d) develop an emergency response strategy to gain information from accidental exposures; and e) conduct hypothesis-driven research in occupationally exposed groups and/or in experimental animals.There was consensus that meetings like this workshop and projects that facilitate interactions between specialties should be encouraged.A multidisciplinary approach is needed to address this problem.
Abstract 3142: Inhibition of the transcription factor Ikaros augments the tumoricidal capacity of CD8+ T cells expressing chimeric antigen receptors
Authors: Shaun O'Brien, Liang-Chuan Wang, Kheng Newick, Rajan M. Thomas, Andrew Wells, Steven M. Albelda
Journal: Cancer Research (2015)

Abstract Recent success of adoptive transfer of T cells expressing chimeric antigen receptors (CARs) in patients with blood-borne malignancies has resulted in growing enthusiasm to apply the same approach to treat solid tumors. CAR-expressing T cells, however, will likely face many challenges that will limit their efficacy in solid tumors. One possible obstacles will be the intrinsic negative feedback systems that prevent continuing T cell responses. The transcription factor Ikaros which has been shown to suppress endogenous T effector functions through epigenetic remodeling of cytokine gene loci may be one such negative regulator. Here we show that anti-mesothelin CAR (mesoCAR) T cells with reduced levels of Ikaros consistently mediate better in vitro cell killing and in vivo tumor regression than their wild-type counterparts. This increased anti-tumor activity was accompanied by increased persistence of mesoCAR T cells, as well as increased IFN-g. Enhanced cytolytic activity was also evidenced in mesoCAR T cells with reduced Ikaros, which could be partially explained by increased CD107a upregulation and Granzyme B production. Reduction in the Ikaros level in mesoCAR T cells did not affect T cell receptor and CAR signaling, but was able to render them more resistant to soluble inhibitory factors like TGF-B and adenosine. In summary, inhibition of the transcriptional repressor Ikaros in CAR T cells could be an attractive strategy to overcome immunosuppressive tumor microenvironments and enhance their tumoricidal capacity. Further clinical development is warranted. Citation Format: Shaun O'Brien, Liang-Chuan Wang, Kheng Newick, Rajan M. Thomas, Andrew Wells, Steven M. Albelda. Inhibition of the transcription factor Ikaros augments the tumoricidal capacity of CD8+ T cells expressing chimeric antigen receptors. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3142. doi:10.1158/1538-7445.AM2015-3142
The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation
Authors: Carolyn A. Cuff, Devashish Kothapalli, Ijeoma Azonobi, Sam Chun, Yuanming Zhang, Richard Belkin, Christine Yeh, Anthony Secreto, Richard K. Assoian, Daniel J. Rader, Ellen Puré
Journal: Journal of Clinical Investigation (2001)

Atherosclerosis causes most acute coronary syndromes and strokes. The pathogenesis of atherosclerosis includes recruitment of inflammatory cells to the vessel wall and activation of vascular cells. CD44 is an adhesion protein expressed on inflammatory and vascular cells. CD44 supports the adhesion of activated lymphocytes to endothelium and smooth muscle cells. Furthermore, ligation of CD44 induces activation of both inflammatory and vascular cells. To assess the potential contribution of CD44 to atherosclerosis, we bred CD44-null mice to atherosclerosis-prone apoE-deficient mice. We found a 50–70% reduction in aortic lesions in CD44-null mice compared with CD44 heterozygote and wild-type littermates. We demonstrate that CD44 promotes the recruitment of macrophages to atherosclerotic lesions. Furthermore, we show that CD44 is required for phenotypic dedifferentiation of medial smooth muscle cells to the “synthetic” state as measured by expression of VCAM-1. Finally, we demonstrate that hyaluronan, the principal ligand for CD44, is upregulated in atherosclerotic lesions of apoE-deficient mice and that the low-molecular-weight proinflammatory forms of hyaluronan stimulate VCAM-1 expression and proliferation of cultured primary aortic smooth muscle cells, whereas high-molecular-weight forms of hyaluronan inhibit smooth muscle cell proliferation. We conclude that CD44 plays a critical role in the progression of atherosclerosis through multiple mechanisms.
Corrigendum to ‘Assessing prediction accuracy for outcomes of ventilator-associated events and infections in critically ill children: a prospective cohort study’ [Clinical Microbiology and Infection, Volume 24, Issue 7 (July 2018) Pages 732–737]
Authors: Y. Peña-López, M. Pujol, M. Campins, L. Lagunes, J. Balcells, J. Rello
Journal: Clinical Microbiology and Infection (2018)
The Permanent
Authors: Aimee Burke Valeras
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Satellite hookup links major US military hospital with Army physicians in Mogadishu, Somalia
Authors: P. Gunby
Journal: JAMA (1993)

GLOBAL TELEMEDICINE is being tested by US military medical personnel in Somalia. As Operation Restore Hope enters its final days—at least as far as the US military playing a dominant role—a remote clinical communication system is in operation at the 86th Evacuation Hospital in Mogadishu. The hospital, which has its home base at the US Army's Fort Campbell (Ky), northeast of Nashville, Tenn, on the Kentucky-Tennessee border, thus now is linked via satellite from Somalia with Walter Reed Army Medical Center, Washington, DC. <h3>Digital Images</h3> Physicians at Walter Reed say the system uses off-the-shelf computers, software, portable telecommunications equipment, and a computerized digital camera. The goal, they say, is to allow military physicians who encounter an unfamiliar or particularly difficult patient problem at a remote site like those in Somalia to consult with experts at a sophisticated center like Walter Reed. This eliminates waiting until the patient has been evacuated
Nomination of Surgeon General of Navy.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GRANULOCYTOPENIA
Authors: William Dameshek
Journal: JAMA (1934)

<h3>To the Editor:—</h3> My reason for commenting on an article inThe Journal, February 17, entitled "Granulocytopenia," by Pauline Zinninger, is that the two cases described may possibly be instances of leukosis (leukemia) rather than of agranulocytosis. The two conditions are frequently confused, despite what may seem at first glance obvious differences. It is becoming increasingly evident that the diagnosis of agranulocytosis, granulocytopenia and the like is being made on the basis of a very low leukocyte count without much consideration being given to the possibility that the leukopenia might not be primary but rather secondary to some such disorder as aplastic anemia, aleukemic leukosis (leukemia), generalized sarcomatosis with involvement of the bone marrow, or even sepsis. True or primary agranulocytosis is probably an intrinsic disorder of the bone marrow (metabolic in type?) in which the granulocytes either do not grow at all or do not properly maturate. Only rarely
Heparin Prophylaxis
Authors: DAVID NICHOLSON
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 November 1983Heparin ProphylaxisDAVID NICHOLSON, M.D.DAVID NICHOLSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-5-738_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Halkin and associates (1) presented the results of a study purporting to show that low-dose heparin resulted in a 31. 1% reduction in mortality in patients admitted to a general medical service. The authors allow that their study was not double blind, and that treatment was allocated after "randomization" by odd and even hospital numbers, which was open to bias as shown by the higher number of contraindications identified in the "heparin" group. The hospital number was determined by a clerk in the emergency room, before evaluation for emergency admission, and a table of random numbers was...References1. HALKINGOLDBERGMODANMODAN HJMB. Reduction of mortality in general medicine in-patients by low-dose heparin prophylaxis. Ann Intern Med. 1982;96:561-5. LinkGoogle Scholar2. MIETTINEN O. Proportion of disease caused or prevented by a given exposure trial or intervention. Am J Epidemiol. 1984;99:325-32. CrossrefGoogle Scholar1. WILCOXONWILCOX FR. Some Rapid Approximate Statistical Procedures. Pearl River, New York: Lederle Laboratories; 1964:28. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID NICHOLSON, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1983Volume 99, Issue 5Page: 738-738KeywordsEmergency departmentHeparinMedical servicesMortalityProphylaxis ePublished: 1 December 2008 Issue Published: 1 November 1983 PDF downloadLoading ...
Cervical cancer, human papillomavirus, and vaccination
Journal: BMJ (2005)

The small number not followed up differed from the overall group but because of the paired design, this does not compromise study validity.Although the numbers enrolled from Northern Ireland were small, they were sufficient to detect significant changes. Implications of findingsThe smoke-free workplace law in the Republic of Ireland seems to have provided protection for one of the most heavily exposed occupational groups.The increase in support for the law in the Republic since its introduction, even among smokers, underpins its effectiveness. 12These findings have implications for legislators in other countries currently considering smoke-free workplace legislation.
Temporal arteritis developing in the course of sulfonamide therapy
Authors: D. K. Lee
Journal: JAMA (1967)

A VARIETY of drugs has been implicated as causal agents in cases of generalized vasculitis, but only one has been proposed to be etiologically related to a case of temporal arteritis (giant-cell arteritis). Kalliomaki and Laurén<sup>1</sup>reported the case of a 63-year-old woman who had classic signs, symptoms, and pathological findings of temporal arteritis three weeks following the initiation of indomethacin therapy. Recently, we have encountered a patient with the classic temporal arteritis syndrome whose symptoms occurred after therapy with sulfonamide, to which he had a known allergy. This case report is prompted by the apparent rarity of association of drug therapy and temporal arteritis as opposed to certain other forms of vasculitis, and the presently obscure relationship between the various vasculitides which may, in part, be further defined by the accumulation of such information. <h3>Report of a Case</h3><h3>Present Illness.—</h3> A 70-year-old white, retired clothing salesman was admitted