tbuckley/cabot-search huggingface dataset:
Diagnosing a Rare but Potentially Deadly Disease of the Adrenal Glands
Journal: Annals of Internal Medicine (1999)

Summaries for Patients19 October 1999Diagnosing a Rare but Potentially Deadly Disease of the Adrenal GlandsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00041 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Primary pigmented nodular adrenocortical disease (PPNAD) is a rare disease of the adrenal glands. The adrenal glands are small glands located above each kidney. The adrenals make hormones. Hormones are chemical substances formed in one organ or part of the body that travel in the blood to other body parts where they influence how that body part works. Cortisol is one of the hormones made by the adrenals. Cortisol influences body metabolism (how the body converts small molecules to large and vice versa) and can decrease inflammation. People ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Paradoxical Response to Dexamethasone in the Diagnosis of Primary Pigmented Nodular Adrenocortical Disease.” It is in the 19 October 1999 issue of Annals of Internal Medicine (volume 131, pages 585-591). The authors are C.A. Stratakis, N. Sarlis, L.S. Kirschner, J.A. Carney, J.L. Doppman, L.K. Nieman, G.P. Chrousos, and D.A. Papanicolaou.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoParadoxical Response to Dexamethasone in the Diagnosis of Primary Pigmented Nodular Adrenocortical Disease Constantine A. Stratakis , Nicholas Sarlis , Lawrence S. Kirschner , J. Aidan Carney , John L. Doppman , Lynnette K. Nieman , George P. Chrousos , and Dimitris A. Papanicolaou Metrics 19 October 1999Volume 131, Issue 8Page: 585KeywordsAdrenal glandsComputed axial tomographyCortisolHormonesLower back painMedical conditionsMusclesPatientsPrimary hypertensionUrine ePublished: 15 August 2000 Issue Published: 19 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
Travaux de. Chirurgie Anatomo-Clinique.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 397: Perivascular Fat Tissue Plays An Atheroprotective Role In Neointimal Formation After Angioplasty
Authors: Minoru Takaoka, Masataka Sata, Ryozo Nagai
Journal: Circulation (2007)

Background: Obesity is associated with chronic inflammation and increases risk for cardiovascular disease and type 2 diabetes. Recently visceral, as opposed to subcutaneous, fat tissue confers the most cardio-metabolic risk. The aim of the present study is to determine whether perivascular fat tissue contributes to neointimal formation after angioplasty. Methods and Results: An endovascular injury was induced in the femoral arteries of wild-type mice without or with removal of perivascular adipose tissue. Neointimal area and Neointima/Media ratio were markedly enhanced by removal of perivascular adipose mice (P=0.05). Visceral fat tissue (VAT) or subcutaneous fat tissue (SAT) were harvested from GFP-transgenic mice and transplanted around the injured femoral without endogenous perivascular fat. Neointimal formation was markedly enhanced in the VAT-transplantation group compared with the SAT-transplantation group (P=0.05). Real-time PCR analysis showed that the transplanted VAT had significantly higher proinflammatory cytokines, TNF alpha, IL-6, MCP-1, and PAI-1, mRNA levels than the SAT (P=0.05). Next, the effects of VAT and SAT on smooth muscle cell proliferation were investigated in vitro. Conditioned medium was prepared from extracts of VAT and SAT. Cell proliferation was measured by MTS assay. VAT stimulated smooth muscle cell proliferation compared with SAT (P=0.05). Conclusions: The present study demonstrates that perivascular adipose tissue protects neointimal formation after angioplasty. VAT stimulates neointimal formation and smooth muscle cell proliferation, probably by secreting proinflammatory cytokines, at least in part. Adipocytokines, particularly secreted from perivascular fat tissue, may play a role in the pathogenesis of neointimal formation after angioplasty.
IgA antibody to spermatozoa in seminal and prostatic fluids of a subfertile man
Authors: S. S. Witkin
Journal: JAMA (1982)

The mechanism of spontaneous sperm agglutination in the ejaculate of a subfertile man was investigated. Using enzyme-linked immunosorbent assays it was found that the patient's spermatozoa had a mean of 2.3 times more IgA bound to it than did spermatozoa from fertile men. IgA antibody to spermatozoa was also found in the patient's seminal fluid and prostatic fluid, but not in his serum. In this patient it appeared that agglutination was due to an IgA antibody to spermatozoa that was produced locally within the genital tract. (<i>JAMA</i>1982;247:1014-1015)
Stroke Conference Will Study Prevention, Care, Research
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cases of Nerve-Disorder
Authors: C. H. Jones
Journal: BMJ (1859)

I am fully aware that many of the symptoms recorded in the above case are at variance with those described by most authors as pathognomonic symptoms of lead.poisoning.There was no wastinig of the muscles; there was no lead-colic; no constipation; there was no dropping of the wrist; there was no atrophy of the ball of the thumb; the motor nerves were not on 20 August
Are there too many US transplantation centers? Some experts suggest fewer, cheaper, and better
Authors: A. A. Skolnick
Journal: JAMA (1994)

WHILE the increase in the number of transplantation centers across the United States may help provide easier and more equitable patient access to services, this growth is not always associated with good outcomes or with the most cost-effective use of donor organs and health care dollars. Such were the views a panel of experts presented at the first joint annual meeting, held in Washington, DC, of the United Network for Organ Sharing (UNOS) and the US Department of Health and Human Services' Division of Organ Transplantation. "Not everybody who wants a center can have one, and we better start to accept this at the outset of discussion," said panelist Charles M. Miller, MD, director of the liver transplant program at Mount Sinai Medical Center, New York, NY. Any hospital with at least one UNOS-approved transplantation program in association with an organ procurement officer and a tissue-typing laboratory can call itself
Abstract 10971: Myocardial Edema in Acute Myocarditis Detected by Echocardiographic 2D Myocardial Deformation Analysis
Authors: Brian B Løgstrup, Jan M Nielsen, Wong Y Kim, Steen H Poulsen
Journal: Circulation (2015)

Introduction: The diagnosis of acute myocarditis is in daily practice based on symptoms, electrocardiography, elevated myocardial necrosis biomarkers, echocardiography and in selected cases supported by myocardial edema and fibrosis demonstrated by cardiovascular magnetic resonance (CMR). Often conventional echocardiography reveals no obvious changes in global function despite and therefore provides limited diagnostic value. Myocardial deformation imaging by echocardiography is an evolving method to quantitatively characterize myocardial function that may be influenced in acute myocarditis. Hypothesis: The aim of our study was to assess deformation imaging of the left ventricle in patients with CMR verified acute myocarditis. Methods: We included 28 consecutive patients (mean age 32±13 years) with CMR verified diagnosis of acute myocarditis by Lake Louise criteria. The cardiac function was evaluated by a comprehensive assessment of left ventricular (LV) function including 2D speckle tracking echocardiography. Results: We found no correlation between LV function assessed by echocardiographic ejection fraction and the amount of edema. However, we found wall motion score index to be significantly correlated to the amount of myocardial edema, however only observed, in patients with &gt;11% edema of the LV. Global longitudinal systolic strain correlated significantly to the amount of edema (r= 0.65; p&lt;0.001). We found that both the epicardial longitudinal- and endocardial longitudinal systolic strain significantly correlated to edema (r=0.55; p=0.003 and r=0.54; p=0.004). No significant correlation was observed analyzing circumferential strain (global: r=0.3; p=0.13; epicardial: r=0.26; p=0.19 and endocardial: r=0.32; p=0.1). However, we found the circumferential strain to be decreased in the infero-postero-lateral region. Conclusions: In patients with acute myocarditis we found 2D speckle tracking echocardiography to be a useful tools in the diagnostic process of acute myocarditis. Myocardial deformation imaging improved the diagnostic accuracy in acute myocarditis patients, especially when conventional echocardiographic parameters of LV are normal.
CRIMINAL MORPHOMANIA AND CHRONIC MORPHINISM. DISCUSSION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of operators skill on direct PTCA outcomes in acute myocardial infarction. A view of the SOLACI registry Costantino Costantini, Sergio Tarbine, Euardo Sousa, Alberto Sampaolesi, S. Silva, C. Gosttchall, Alfredo Rodriguez, M Martinez Rios, G Bonzon, Espedito Ribeiro, F. Tortoledo, Gregg W. Stone. Clinica Cardiologyca C. Costantini, Curitiba, Brazil
Journal: Journal of the American College of Cardiology (2001)
Injuries to boys who scramble.
Authors: M Place
Journal: BMJ (1979)

economic advantage has been shown in our study, the greatest benefit must be of more time for the patient who requires this, whether for further investigation or treatment.The conventional arrangements for follow-up of patients from hospital may be inappropriate for the asymptomatic patient who does not require clinical measurement or hospital investigative facilities.The success of this investigation suggests that a system of reply-paid cards can provide an efficient and realistic method of review.If applied selectively this system could have enormous potential advantage for patients, staff, and the National Health Service.We thank Mr J W Fowler for permission to include his patients in the survey; the nursing staff of our day bed unit and diagnostic theatre for their help;
P100 Designing and implementing a COPD discharge care bundle
Authors: N. S. Hopkinson, C. Englebretsen, N. Cooley, K. Kennie, M. Lim, T. Woodcock, A. Laverty, S. Wilson, S. L. Elkin, C. Caneja, C. Falzon, H. Burgess, D. Bell, D. Lai
Journal: Thorax (2011)

<h3>Problem</h3> Acute exacerbations of COPD are a major cause of hospital admission and readmission. National surveys have revealed significant differences in patient outcomes which are likely to be due to variations in care. <h3>Design</h3> A care bundle, comprising a short list of evidence-based practices to be implemented prior to discharge for all patients admitted with this condition was developed, based on a review of National Guidelines and other relevant literature, expert opinion and patient consultation. Implementation was then piloted using action research methodologies in an urban acute hospital. <h3>Key measures for improvement</h3> Improvements in process measures based around the items in the care bundle were the provision of smoking cessation advice, referral for pulmonary rehabilitation, and review of inhaler technique. A 72 h post-discharge phone call was evaluated. Data from the first year of the bundle were compared with the year prior to its initiation including 30-day readmission rate. <h3>Strategies for change</h3> The care bundle was launched with events to ensure staff awareness. Weekly meetings were held with review of bundle compliance so that areas for attention could be addressed promptly. A plan, do, study, act (PDSA) cycle approach was used. Examples included ongoing support to develop ward nurses9 knowledge of correct inhaler use, nurses attending pulmonary rehabilitation sessions and the use of a "safe discharge" checklist. <h3>Effects of change</h3> Referral to pulmonary rehabilitation increased by 158% and compliance with assessment for smoking cessation was 100%. Nurse confidence in inhaler technique improved. Roughly 10% of post discharge phone calls identified a cause for concern. The 30-day readmission rate was 10.8% for patients where the bundle was used (n=94) compared to 16.4% where it was not (n=365) (95% CI for difference −2.1% to 13.2%). The bundle has been accepted onto the list of CQUIN measures by London SHA and is being rolled out to further sites. <h3>Lessons learnt</h3> Actively involving all staff is vital to ensure that the changes introduced are understood and the process followed. Implementation of a care bundle has the potential to produce a dramatic improvement in compliance with optimum health care measures.
Ovarian overstimulation, massive ascites, and Singleton pregnancy after clomiphene
Authors: A. Scommegna
Journal: JAMA (1969)

Bilateral ovarian enlargement with massive ascites and pregnancy occurred in a patient after two courses of clomiphene citrate (Clomid) therapy. It is likely that the patient received the second course of clomiphene during early stages of pregnancy. Early pregnancy must be ruled out prior to the administration of this type of therapy.
The Utility of Prostate-Specific Antigen for Detecting Prostate Cancer
Authors: Edward H. Livingston
Journal: JAMA (1995)

<h3>To the Editor.</h3> —A colleague of mine approached me rather concerned because his most recent PSA level was 3.8 ng/mL. According to Dr Gann and colleagues,<sup>1</sup>his risk for developing prostate carcinoma is eightfold greater than if his PSA level had been less than 1.0 ng/mL. His question was this: What do I do now? It is not intuitively obvious that the risk of developing prostate cancer is increased eightfold if the PSA level is between 3 and 4 ng/mL because, in the study by Gann et al, 37 (10.1%) of 366 patients with prostate cancer had a PSA level between 3 and 4 ng/mL, yet 29 (7.9%) of the 366 cancer patients had PSA levels of less than 1.0 ng/mL. One way to gain perspective on this discrepancy is to track what happens to a group of patients receiving screening. Using the proportions found in the study by
&lt;TITLE&gt;Rabies&lt;/TITLE&gt;
Journal: JAMA (2000)

public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
THE DISASTER AT GALVESTON.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Your Baby: The Complete Baby Book for Mothers and Fathers
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Depressions in Childhood and Adolescence
Authors: Carl P. Malmquist
Journal: New England Journal of Medicine (1971)

AMONG the many unresolved clinical and theoretical problems in medicine, the nature of depression is in the forefront. Childhood depressions are among the most conspicuous for lack of knowledge. It is perhaps a valid statement that this is one of the clinical conditions of childhood whose diagnosis is most widely missed and hence unreported. The subject is avoided to the extent that most textbooks of child psychiatry or childhood psychopathology either fail to mention it or make a cursory reference to it in connection with deprivation-type syndromes. In fact, the question whether children merely experience states of sadness or manifest . . .
Addiction Medicine
Authors: Donald R. Wesson
Journal: JAMA (1996)

Addiction medicine is practiced by a diverse group of physicians from different treatment settings: clinics providing methadone or other opiate replacement therapy to heroin addicts, chemical dependency treatment hospitals, publicly funded drug abuse treatment clinics, and private practice. The various groups of addiction medicine specialists evolved independent of one another and of mainstream medicine. Regulations and funding mechanisms for drug abuse treatment fostered separation from mainstream medicine. Public funding of drug abuse treatment, especially opioid maintenance therapy, is not part of the national health care budget. Most public-sector drug abuse treatment is funded through block grants to states from the Center for Substance Abuse Treatment, part of the federal government's war on drugs. Physicians are legally prohibited from prescribing opioid substitution medications for heroin addicts, except in specially licensed clinics. The methadone maintenance treatment system, which evolved outside mainstream medicine, is still tightly regulated by the Food and Drug Administration