Abstract 1610: Getting under the skin: Fat quality in esophageal cancer prognosis
Authors: Maelle Anciaux, Lieveke Ameye, Thomas Guiot, Patrick Flamen, Serge Goldman, Pieter Demetter, Amélie Deleporte, André Van Gossum, Marianne Paesmans, Vincent Donckier, Alain Hendlisz, Caroline Vandeputte
Journal: Cancer Research (2019)

Abstract INTRODUCTION The last few years have seen an increased interest in the role of body mass composition parameters in cancer survival. this study sought to assess the impact of the body mass composition (BMC) on prognosis of locally advanced esophageal cancer (EC) patients beyond the usual quantitative weight loss associated with this condition. METHODS Diagnostic CT scans were assessed for BMC in 155 all-stage EC patients at diagnosis. The index (area/height2) of skeletal muscle (SMI), subcutaneous (SFI) and visceral fat (VFI) were delineated on two adjacent slides at the third lumbar vertebra level by two independent investigators using PLANET ONCO® software (DOSIsoft, France). Mean attenuation (or density) of fat tissue was measuring to assess the quality of adipose compartments. Survival and relapse free survival (RFS) were calculated from date of baseline CT-scan. RESULTS Interobserver correlations were excellent for all BMC parameters measured (r = 0.94 to 0.99). Remarkably, low subcutaneous fat density (SFD) was associated to better outcome, as were low disease stages. Low C-reactive protein (CRP) levels were also associated with better overall survival (OS). In contrast, low BMI did not affect the patients’ outcome. Relapse free survival (RFS) analysis showed that only high disease stages and SFD remained associated with poor RFS. Stepwise regression showed that the combination of SFD, stage and CRP was an effective model for OS prediction. No parameter was retained for RFS in the multivariate analysis. Detailed results are shown in Table 1. CONCLUSION SFD, stages and CRP appeared as robust prognostic factors of OS in EC patients, in contrast with BMI. While SFD and stages were significant in RFS univariate analysis, none of these two parameters were retained in multivariate analyses. These results confirm the validity of BMC assessment for evaluating patient prognosis and show for the first time that adipose tissues and inflammation may have a preponderant impact on cancer prognosis. ParametersThresholdOSmalefemalep valueHR (95 CI)Low SFD&amp;lt; -95,7&amp;lt; -99,40,000282,2 (1,4-3,5)Low disease stages1+2A vs 2B+3+40,00472,2 (1,2-3,7)Low CRP&amp;lt; 3,200,00532,2 (1,2-3,8)Low BMI&amp;lt;250,130,71 (0,46-1,1)ParametersThresholdRFSmalefemalep valueHR (95 CI)Low SFD&amp;lt; -95,7&amp;lt; -99,40,041,6 (1-2,6)Low disease stages1+2A vs 2B+3+40,0441,8 (1-3,1)N.B. Thresholds for SFD are the sex-specific medians. Thresholds for CRP is the median Citation Format: Maelle Anciaux, Lieveke Ameye, Thomas Guiot, Patrick Flamen, Serge Goldman, Pieter Demetter, Amélie Deleporte, André Van Gossum, Marianne Paesmans, Vincent Donckier, Alain Hendlisz, Caroline Vandeputte. Getting under the skin: Fat quality in esophageal cancer prognosis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1610.