tbuckley/cabot-search huggingface dataset:
Left Atrial Pressure Elevation May Boost Vascular Resistance
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Measles immunization
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serological Identification of HSP105 as a Novel Non-Hodgkin Lymphoma Therapeutic Target
Authors: Roberta Zappasodi, Gaia C Ghedini, Italia Bongarzone, Lorenzo Castagnoli, Maida de Bortoli, Piera Aiello, Alessandra Cavanè, Antonello D Cabras, Carmelo Carlo-Stella, Alessandro M. Gianni, Serenella M Pupa, Massimo Di Nicola
Journal: Blood (2010)
Criteria for Facilities and Personnel for the Administration of Parenteral Systemic Antineoplastic Therapy
Journal: Journal of Clinical Oncology (2004)

The following American Society of Clinical Oncology (ASCO) position statement represents an update to policy first adopted by the Board in 1997 (J Clin Oncol 15:3416-3417, 1997). The primary change to the statement is the addition of language to section 7, Standards for Antineoplastic Therapy, describing safeguards for preparing and administering chemotherapy drugs. As third-party payors consider and follow through with the establishment of new models for chemotherapy drug procurement, distribution, and delivery, ASCO provides guidance to oncologists to help them ensure the safety and integrity of the drugs they administer. Additionally, section 5, Office Operations, also suggests that oncologists consider measures protecting them from liability associated with drugs obtained from or prepared by outside entities.
TYPHOID INFECTION OF EXISTING LESIONS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UK survey finds variation in oestrogen receptor testing
Authors: S. Mayor
Journal: BMJ (2001)

4.2%), the mean length of stay (11.7, 13.4, and 12.6 days), or the incidence of postoperative myocardial infarction (4.5%, 3.4%, and 4.2%)," concludes the study."The total cost of coronary artery bypass grafting per patient did not differ significantly between the three groups." David Spurgeon QuebecSmoking may mimic effect of antidepressants
COTTONSEED ALLERGY
Authors: SAMUEL J. TAUB
Journal: JAMA (1934)

The rôle of cottonseed as an etiologic factor in asthma, perennial hay fever, eczema and urticaria has not been sufficiently emphasized in the literature to the present time. Most allergists consider cottonseed sensitivity as not particularly common but a very potent factor in producing severe symptoms. These patients are consequently difficult to treat. Aaron Brown<sup>1</sup>states that 2 per cent of allergic patients react to cottonseed, while Cooke<sup>2</sup>finds 0.6 per cent. These authors, however, do not mention the total number of patients tested. G. T. Brown<sup>3</sup>reports that 2.4 per cent of 530 patients reacted to cottonseed, but he does not state whether these 530 patients were definitely allergic to other substances. The basis for my report comprises 246 allergic patients, who had complete skin tests with some 300 separate allergens. Thirteen reacted specifically to cottonseed. Of this group, six patients had asthma, two patients had
Refuse Service
Authors: E. D. Broster
Journal: BMJ (1948)

<h3>Objective</h3> Our aim is to review, and qualitatively evaluate, the aims and measures of social referral programmes. Our first objective is to identify the aims of social referral initiatives. Our second objective is to identify the measures used to evaluate whether the aims of social referral were met. <h3>Design</h3> Literature review. <h3>Background</h3> Social referral programmes, also called social prescribing and emergency case referral, link primary and secondary healthcare with community services, often under the guise of decreasing health system costs. <h3>Method</h3> Following the PRISMA guidelines, we undertook a literature review to address that aim. We searched in five academic online databases and in one online non-academic search engine, including both academic and grey literature, for articles referring to ‘social prescribing’ or ‘community referral’. <h3>Results</h3> We identified 41 relevant articles and reports. After extracting the aims, measures and type of study, we found that most social referral programmes aimed to address a wide variety of system and individual health problems. This included cost savings, resource reallocation and improved mental, physical and social well-being. Across the 41 studies and reports, there were 154 different kinds of measures or methods of evaluation identified. Of these, the most commonly used individual measure was the Warwick-Edinburgh Mental Well-being Scale, used in nine studies and reports. <h3>Conclusions</h3> These inconsistencies in aims and measures used pose serious problems when social prescribing and other referral programmes are often advertised as a solution to health services-budgeting constraints, as well as a range of chronic mental and physical health conditions. We recommend researchers and local community organisers alike to critically evaluate for whom, where and why their social referral programmes ‘work’.
Smoking, alcohol, and neuromuscular function in older women
Authors: G. Spilich
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Dr Nelson and colleagues<sup>1</sup>report that in a multicenter study of almost 10 000 women across the United States, smokers showed a reliable loss of agility, strength, and integrative physical function even when such factors as age, history of stroke, body mass index, physical activity, and alcohol use were controlled. They go on to state that the physical performance deficit for an elderly smoker is roughly equivalent to the decline associated with an additional 5 years of age, and that amount of smoking is related to amount of performance decline. These last two observations indicate that the tobacco-related decline in physical performance is both clinically relevant and dose related. Although their data are important in their own right, their work takes on additional relevance when the question of tobacco's effects on performance is viewed globally. We know, for instance, that risk of vehicular accident (expressed as
Unilateral absent perfusion of the lung
Authors: T. A. Tomsick
Journal: JAMA (1975)

<h3>Common</h3> 1. Bronchogenic Carcinoma<sup>1</sup> <h3>Less Common</h3> Pulmonary embolism' Parenchymal or pleural disease, severe<sup>1</sup> Congenital heart disease, after shunting procedure<sup>1</sup> After pneumonectomy<sup>1</sup> <h3>Rare</h3> Hyperlucent lung syndrome<sup>1</sup> Stenosis of pulmonary artery, hypoplasia, or agenesis of the lung or pulmonary artery<sup>2,3</sup> Endobronchial foreign body<sup>4,5</sup> Pulmonary veno-occlusive disease<sup>6</sup> Bronchial adenoma<sup>7</sup> (The Gamut approach to roentgenologic diagnosis has been applied to nuclear medicine [L.E. Holder et al, unpublished data]. Though scintiscan abnormalities are often less specific than roentgenographic changes, the method has proved useful.) <h3>Diagnosis</h3> Bronchogenic carcinoma. <h3>Comment</h3> The patient was a 73-year-old man with a chronic cough who had been a two-pack-per-day cigarette smoker for many years. The chest roentgenogram (Fig 1) was taken when he complained of coughing up a few flecks of blood. Hemoptysis continued, and one month later a perfusion lung scan with macroaggregated iodinated I 131 serum albumin was obtained
Historical and Modern Epidemiological Studies on Populations Exposed to N-Substituted Aryl Compounds
Authors: R. A. Cartwright
Journal: Environmental Health Perspectives (1983)

The historical exposures to aromatic amines of various occupational groups are briefly reviewed. Modern studies indicate that other occupational groups might have risks worth investigating; these include machinists and workers in the chemical industry. Details of a recent investigation into the exposure of dye workers are given which indicate a lowered risk in recent years since the introduction of safety measures. Nonoccupational exposures to the aromatic amines are also discussed. They include cigarette smoking and phenacetin abuse, the former being a potent causal agent in bladder cancer.
Low-Dose Tamoxifen for the Treatment of Breast Ductal Intraepithelial Neoplasia: Results of a Large Observational Study.
Authors: A. Guerrieri-Gonzaga, E. Botteri, M. Lazzeroni, M. Lazzeroni, B. Bonanni, N. Rotmensz, A. Goldhirsch, C. Varricchio, D. Serrano, M. Cazzaniga, A. Luini, G. Viale, G. Viale, S. Mora, G. Bollani, E. Albertazzi, A. Decensi, A. Decensi
Journal: Cancer Research (2009)

Abstract Background: The cost-benefit ratio of tamoxifen for breast ductal intraepithelial neoplasia (DIN) is unclear. Since low-dose tamoxifen showed a favorable safety profile and modulation of breast cancer biomarkers in phase II trials, we analyzed a large mono-institutional cohort of women with DIN treated with low-dose tamoxifen or no systemic treatment.Material and Methods: A total of 309 patients with ER positive DIN received either tamoxifen 5 mg/day or 20 mg/week, as part of clinical trials or institutional guidelines and were compared with 371 patients who received no systemic treatment after surgery with or without radiotherapy due to personal preference, allocation to placebo or contraindication to tamoxifen.Results: The 5-year cumulative incidence of recurrence was 14.5% (95% CI, 11.9-17.5), with a negative trend according to age. Women with ER/PgR &amp;gt;50% DIN who were untreated had a higher incidence of breast events than women on tamoxifen (HR 1.76; 95% CI, 1.00-3.12) or women with ER/PgR&amp;lt;50% DIN (HR 1.72; 95% CI, 1.14-2.58). Among untreated patients with ER&amp;gt;50% DIN, recurrence was higher in PgR ≥50% DIN than in PgR &amp;lt;50% DIN, whereas it was similar among low PgR (&amp;lt;50%) DIN against which tamoxifen had no effect. No difference in endometrial cancer incidence was noted.Discussion: High ER and especially high PgR expression is a significant adverse prognostic indicator of DIN against which low-dose tamoxifen appears to be a safe and active treatment. Conversely, women with low expression ER or PgR DIN do not seem to benefit from tamoxifen. A definitive clinical trial is warranted. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2113.
Displacement of the Superior Cerebellar Artery
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 538: LC-MS based catabolite identification study of an ADC with DM21-C, a novel maytansinoid linker-payload
Authors: Janet Lau, Paulin Salomon, Kerstin Sinkevicius, Juliet Costoplus, Megan Fuller, Raymond Xu, Stuart Hicks, Ravi Chari, Wayne Widdison, Nicholas Yoder, Thomas Keating
Journal: Cancer Research (2019)

Abstract ImmunoGen’s newest antibody-drug conjugate (ADC) design uses the novel maytansinoid linker-payload, DM21-C that bears a peptidase/protease cleavable linker. These ADCs show good bystander killing of proximal antigen negative cells, suggesting the generation of cell-permeable catabolites. The goal of this study was to identify the catabolites generated upon incubation in antigen-positive cancer cells (both cell pellet and media), in mouse plasma, as well as in in vitro catabolic systems. Upon incubation with a cysteine-conjugated DM21-C ADC, the small molecule fraction was extracted with an organic solvent and analyzed by high resolution mass spectrometry after chromatographic separation. Through comparison to reference standards, mass spectral signal extraction of possible products, and database search of unknown peaks, the potential in vitro catabolite products of DM21-C conjugate were identified. Information on linker-payload stability in these model systems, including plasma stability, in vitro metabolism of the ADC, and catabolic products that were both retained and effluxed from cancer cells was obtained. As a result, we identified DM51 (the thiol- resulting from self-immolation of the cleaved linker-payload) as a major catabolite of the DM21-C ADC. Citation Format: Janet Lau, Paulin Salomon, Kerstin Sinkevicius, Juliet Costoplus, Megan Fuller, Raymond Xu, Stuart Hicks, Ravi Chari, Wayne Widdison, Nicholas Yoder, Thomas Keating. LC-MS based catabolite identification study of an ADC with DM21-C, a novel maytansinoid linker-payload [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 538.
The Responsibilities of the Medical Profession in the Use of X Rays and Other Ionizing Radiation&lt;subtitle&gt;Statement by the United Nations Scientific Committee on the Effects of Atomic Radiation&lt;/subtitle&gt;
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article The Responsibilities of the Medical Profession in the Use of X Rays and Other Ionizing Radiation: Statement by the United Nations Scientific Committee on the Effects of Atomic Radiation Get access JNCI: Journal of the National Cancer Institute, Volume 18, Issue 3, March 1957, Pages 481–485, https://doi.org/10.1093/jnci/18.3.481 Published: 01 March 1957
Reducing INDEL calling errors in whole genome and exome sequencing data
Authors: Han Fang, Yiyang Wu, Giuseppe Narzisi, Jason A O¿Rawe, Laura T Jimenez Barrón, Julie Rosenbaum, Michael Ronemus, Ivan Iossifov, Michael C Schatz, Gholson J Lyon
Journal: Genome Medicine (2014)

INDELs, especially those disrupting protein-coding regions of the genome, have been strongly associated with human diseases. However, there are still many errors with INDEL variant calling, driven by library preparation, sequencing biases, and algorithm artifacts. We characterized whole genome sequencing (WGS), whole exome sequencing (WES), and PCR-free sequencing data from the same samples to investigate the sources of INDEL errors. We also developed a classification scheme based on the coverage and composition to rank high and low quality INDEL calls. We performed a large-scale validation experiment on 600 loci, and find high-quality INDELs to have a substantially lower error rate than low-quality INDELs (7% vs. 51%). Simulation and experimental data show that assembly based callers are significantly more sensitive and robust for detecting large INDELs (>5 bp) than alignment based callers, consistent with published data. The concordance of INDEL detection between WGS and WES is low (53%), and WGS data uniquely identifies 10.8-fold more high-quality INDELs. The validation rate for WGS-specific INDELs is also much higher than that for WES-specific INDELs (84% vs. 57%), and WES misses many large INDELs. In addition, the concordance for INDEL detection between standard WGS and PCR-free sequencing is 71%, and standard WGS data uniquely identifies 6.3-fold more low-quality INDELs. Furthermore, accurate detection with Scalpel of heterozygous INDELs requires 1.2-fold higher coverage than that for homozygous INDELs. Lastly, homopolymer A/T INDELs are a major source of low-quality INDEL calls, and they are highly enriched in the WES data. Overall, we show that accuracy of INDEL detection with WGS is much greater than WES even in the targeted region. We calculated that 60X WGS depth of coverage from the HiSeq platform is needed to recover 95% of INDELs detected by Scalpel. While this is higher than current sequencing practice, the deeper coverage may save total project costs because of the greater accuracy and sensitivity. Finally, we investigate sources of INDEL errors (for example, capture deficiency, PCR amplification, homopolymers) with various data that will serve as a guideline to effectively reduce INDEL errors in genome sequencing.
Genetics
Authors: R. L. Teplitz
Journal: JAMA (1979)

<h3>Synthesized DNA and the Genetic Code</h3> In last year's CONTEMPO,<sup>1</sup>I hinted at the exciting and profound impact that recombinant DNA research might have on our practice of medicine. Shortly thereafter the news broke that a team of scientists from the City of Hope National Medical Center, Duarte, Calif; the University of California at San Francisco (UCSF); and the Salk Institute in La Jolla, Calif, had successfully obtained a human peptide hormone—somatostatin—from the bacterium<i>Escherichia coli</i>.<sup>2</sup>This team was composed of Arthur D. Riggs, PhD; Keiichi Itakura, PhD; Roberto Crea, PhD; Tadaaki Hirose, PhD; Herbert L. Heyneker, PhD; Francisco Bolivar, PhD; and Herbert W. Boyer, PhD. Now the City of Hope and UCSF components of the team have been able to obtain the α- and β-peptides of insulin from the same organism.<sup>3</sup>Two such triumphs within little more than one year must be considered a scientific achievement
Retroperitoneal fibrosis associated with atenolol.
Authors: D W Bullimore
Journal: BMJ (1980)

treating underlying disease or at affecting mood and an understanding emotional support.Having said all this, one must still welcome the study by Bungay et al as a carefully executed and well presented account of the verbal aspects of the folkloric expression of the menopause in southern Britain and the pool of "middle-age symptoms" from which they are chosen.
Present status of plastic surgery
Authors: K. L. Stephenson
Journal: JAMA (1975)

THE ADVANCES in plastic surgery during the past year have been made in diverse areas. The field of plastic surgery has been extended by increased knowledge of the principles and techniques of microvascular anastomosis. Replantation of extremities and transplantation of large, free, compound grafts of tissue have been the result. Chinese surgeons,<sup>1</sup>because of their country's rapid rate of industrialization, have encountered a great number of cases suitable for replantation and have developed the following principles: (1) The anastomosis of two veins for each artery is necessary to minimize edema. (2) Primary nerve repair gives superior results and, as a result, protective sensation permits lower-extremity replants. (3) Definitive musculotendinous repairs at the time of replantation are preferable. Their experience with successful reimplantation after an ischemic period of up to 36 hours, if the amputated part had been immediately cooled, has made it obligatory for any physician caring for such