tbuckley/cabot-search huggingface dataset:
THE MECHANISM OF SHOCK AND EXHAUSTION
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of an Ovulatory Suppressant on Serum Protein-Bound Iodine and Red Blood Cell Uptake of Radioactive Tri-Iodothyronine
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Prospective Trial of Intravenous Streptokinase in Acute Myocardial Infarction (I.S.A.M.)
Journal: New England Journal of Medicine (1986)

Within six hours after the onset of symptoms of myocardial infarction, we randomly assigned 1741 patients up to 75 years of age to a one-hour intravenous infusion of 1.5 million IU of streptokinase or placebo. At 21 days mortality was 6.3 percent in the streptokinase group and 7.1 percent in the placebo group. Of those treated within three hours of the onset of symptoms, 5.2 percent died in the streptokinase group (n = 477), as compared with 6.5 percent in the placebo group (n = 463). These differences were not significant. The time to peak serum levels of creatine kinase of myocardial origin (CK-MB) after the onset of symptoms was significantly shorter (13.9 vs. 19.2 hours), and the integrated area under the CK-MB curve (CK-MB infarct size) was significantly smaller, in the streptokinase group (P less than 0.02). Angiograms obtained in 848 patients three to four weeks after infarction revealed that the streptokinase group had higher global ejection fractions (56.8 vs. 53.9 percent, P less than 0.005) and regional ejection fractions (all patients in group, P less than 0.005; patients with anterior or inferior infarctions, P less than 0.05). We conclude that beginning intravenous streptokinase infusion early after the onset of myocardial infarction limits the size of the infarct regardless of its localization. There was, however, only a trend toward reduced mortality at 21 days.
Archives of Otolaryngology, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE INFLUENCE OF PUBLISHERS UPON MEDICAL LANGUAGE AND LITERATURE.
Journal: JAMA (1896)

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Antithyroid Drugs
Authors: David S. Cooper
Journal: New England Journal of Medicine (2005)

Antithyroid drugs, which have been available for more than half a century, are important in the management of hyperthyroidism, particularly in patients with Graves' disease, who have a high response rate. Since the responses of patients vary and these agents have potentially serious side effects, a working knowledge of their complex pharmacology is required. This review article considers recent pharmacologic and clinical data related to the use of these compounds.
Error in 2 Figures
Authors: Thomas Agoritsas, Arnaud Merglen, Gordon Guyatt
Journal: JAMA (2017)

Neil M. Paige, MD, MSHS; Isomi M. Miake-Lye, BA; Marika Suttorp Booth, MS; Jessica M. Beroes, BS; Aram S. Mardian, MD; Paul Dougherty, DC; Richard Branson, DC; Baron Tang, PT, DPT; Sally C. Morton, PhD; Paul G. Shekelle, MD, PhD
Biological Effects of Vinyl Chloride: An Experimental Study
Authors: M. Winell, B. Holmberg, T. Kronevi
Journal: Environmental Health Perspectives (1976)

Plasma activities of alkaline phosphatase, (AP), transaminases and total lactate dehydrogenase (LDH) with isoenzymes were determined in mice inhaling 50 and 550 ppm vinyl chloride (VC). The animals were also autopsied and the tissue pathology was studies. The total LDH activity was elevanted in both dose groups along with a shift to cathodic enzymes. AP was increased in animals exposed to 500 ppm and transaminases were not at all changed. Enzyme changes occurred after the appearance of tumors. Alveologenic adenomas occurred in all animals at the higher dosage and in about half of the animals inhaling the lower dose. Subperitoneal and subcutaneous hemangiosarcomas were frequent in both dose groups; but especially among 50 ppm animals. Only one animal had a hemangiosarcoma of the liver. No liver fibrosis was seen. All primary subperitoneal and subcutaneous tumors were located in fat tissue. Telangiectasis was observed in two animals in the 500 ppm series. The importance of blood vessel changes in the toxicology of vinyl chloride is discussed.
THE WORKING OF THE TENNESSEE MEDICAL LAW.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Operative Surgery . Volumes I and II, fifth edition. By J. Shelton Horsley, M.D., LL.D., and Isaac A. Bigger, M.D. With contributions by C. C. Coleman, M.D., Austin I. Dodson, M.D., John S. Horsley, Jr., M.D., and Donald M. Faulkner, M.D. 4°, cloth; Volume I, 768 pp., with 802 illustrations, and Volume II, 1567 pp., with 1391 illustrations. St. Louis: C. V. Mosby Company, 1940. $18.00 (set).
Journal: New England Journal of Medicine (1941)
Error in Medicine
Authors: Michael Guarnieri
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Dr Leape's<sup>1</sup>article on error in medicine offers a thoughtful and timely comment on a critical problem in health care. Unfortunately, one of the prescriptions may be dangerous medicine: the recommendation to simplify tasks to reduce errors. At first glance, the recommendation appears attractive. Some businesses have already adopted the practice of "dumbing down" jobs. Instead of training workers, the idea is to make the work so simple that people do not have to read, write, add, or even think. For example, to dumb down a dispensary, install electronic scanners. Dumb down fast-food jobs with pictures on cash register keys instead of numbers. Dumb down jobs in the billing office by imposing standard protocols so rigid that little independent judgment is required or even allowed. Dumbing-down employers opt out of investing in the workforce. They view training people as too expensive. Employers even have dumbed down
Patients Leaving Emergency Departments Without Being Seen by a Physician
Authors: H. Range Hutson
Journal: JAMA (1992)

<h3>To the Editor.</h3> —In response to a very timely editorial by Dr Kellermann,<sup>1</sup>we propose adding further strategies to the five put forth by the American College of Emergency Physicians to address the problem of overcrowding of emergency departments. Not only has the cost of health care skyrocketed, the cost of obtaining a medical education has substantially increased as well. It is now common to see physicians graduating from medical school with debts greater than $100000. Many minority graduates are dissuaded from returning to work in the inner city by the financial pressures of repaying student loans and providing for their families. In many cases, the choice of specialty training itself is dictated by financial considerations rather than aptitude or interest. There are no financial incentives to encourage graduating residents with high educational debts to return to the inner city where reimbursement on a per-case basis is low
TURKEY
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OSTEOPATHS vs. OSTEOPATHY
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
History of the Last Illness of Sir Astley P. Cooper, Bart: And Examination of the Body After Death
Journal: BMJ (1841)

vision to contraction of the oblique muscles, and not of the recti, as M. Guerin does.In one case, that of a medical student, 22 years of age, M. Bonnet divided both inferior oblique muscles with the best effects; in two other cases of simple myopia, which had existed from infancy, the improvement was great, but a complete cure did not ensue.Finally, in two cases where myopia was complicated with some amaurotic symptoms, such as " sparks" in the eyes, fixed look, &c., no benefit whatever was obtained; one case, indeed, seemed to have been much relieved during two days, but afterwards relapsed to its former state.TREATMENT OF STUTTERING BY DIVISION OF THE GENIO-GLOSSI MUSCLES.' Sir Astley wore a piece of cork adapted to the umbilicus, and maintained in its place by straps of adhesive plaster, during many years, aiid until his fatal illness.* Sir Astley Cooper wore a truss on the right iDguinal canal from the age of 19 to 25.
Evaluation of the Health Hazard of Clove Cigarettes
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiosensitisers.
Journal: BMJ (1980)

improvement in forced expiratory volume both before and after treatment with bronchodilators (p<0.001) was seen in the group treated with methylprednisolone.Several mechanisms might account for the improvement in lung function seen with the corticosteroid.Suppression of the inflammatory response6 could have reduced airflow obstruction.7 Beta2-adrenergic-receptor responsiveness might have increased,8 or the steroid-induced euphoria might have resulted in an increased respiratory effort.5Corticosteroids given by mouth also have these properties, and so may be useful additional treatment for patients with chronic bron- chitis and intractable symptoms of cough and dyspnoea which persist despite aggressive physiotherapy and bronchodilators.The rational approach to treating chronic bronchitis is to attempt to achieve maximum reversibility of airways obstruc- tion with bronchodilators and physiotherapy.If this fails to produce stabilisation or improvement a "trial of steroids" may be undertaken.Many physicians are reluctant to pre- scribe steroids for chronic bronchitis because of the com- plications associated with this treatment.Since, however, complications relate more to dosage than duration of treatment a suitable regimen for a trial of steroids is oral prednisolone 25-30 mg daily for two to four weeks.4This allows time for a response to develop and should not produce undesirable side effects.Regular objective measurements in the form of spirometry with and without bronchodilators and estimation of arterial gas tensions should be made throughout the trial.If improvement is shown to occur on objective tests, the dosage should be tapered to the lowest level that maintains that improvement.Lack of objective response is a clear indication that treatment should be stopped.Though the result of the work by Albert et a15 is encouraging, the decision to undertake a trial of steroids should be made not indis- criminately but on an individual basis.1 Hume KM, Jones ER.Bronchodilators and corticosteroids in asthma.Forced expiratory volume as an aid to diagnosis and treatment.
Dissection sous-muqueuse pour cancer gastrique précoce: est ce que les critères de résection étendus sont sécuritaires pour les patients occidentaux
Journal: Endoscopy (2017)

La dissection sous muqueuse est devenue le traitement de référence du cancer superficiel de l’estomac. La prévalence élevée de ces tumeurs en orient a conduit à la publication de plusieurs recommandations sur la place du traitement endoscopique. Dans les années 1990, la mucosectomie était recommandée, mais limitée aux petites lésions (moins de 20 mm pour les lésions surélevées, moins de 10 mm pour les lésions déprimées): il s’agit des “critères classiques”. En 2000 les critères de résection endoscopique étaient étendus à des lésions de plus grande taille, aux petites lésions ulcérées, aux petites lésions étendues : il s’agit des “critères classiques”.
Penicillamine therapy 'encouraging' in primary biliary cirrhosis study
Authors: M. Reed
Journal: JAMA (1982)

Encouraging results are being reported from an eight-year, double-blind, controlled trial of penicillamine in the treatment of primary biliary cirrhosis. Speaking at the recent Digestive Disease Week meetings in Chicago, gastroenterologist E. Rolland Dickson, MD, head of the section of gastroenterology at the Mayo Clinic, Rochester, Minn, and chairman of the board of the American Liver Foundation, said that histological progression of the disease has been retarded, liver function has improved, and "temporary improvement in survival" has been achieved. There are a number of adverse side effects, however. Once thought to be rare, primary biliary cirrhosis is now being reported with much greater frequency, Dickson told<i>JAMA</i>MEDICAL NEWS. This is largely due to the ability of tests now routine in many physical examinations (such as that for serum alkaline phosphatase levels) to uncover early and asymptomatic cases. Although about 90% of those with the disease are women, there is
Acetaminophen Hepatotoxicity, Fasting, and Ethanol
Authors: Herbert L. Bonkovsky
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I read with interest the article by Drs Whitcomb and Block<sup>1</sup>as well as the accompanying Editorial by Dr Strom.<sup>2</sup>Despite the well-described toxicity of high doses of acetaminophen, it remains a generally safe analgesic, especially when compared with other readily available and widely used minor analgesics such as aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs). Occasionally, some patients may develop serious liver injury, including those who do not take more than prescribed or more than generally recommended doses. I observed and described one such patient more than 15 years ago.<sup>3</sup> More recently, my colleagues and I had the opportunity to care for and study a 67-year-old man with chronic underlying cardiopulmonary disease who developed severe hepatic and moderately severe renal injury after short-term ingestion of therapeutic doses of acetaminophen (1 to 3 g/d for 3 days). Acetaminophen metabolism and other studies performed 5 months