tbuckley/cabot-search huggingface dataset:
Coeliac disease in the elderly
Authors: G. K. T. Holmes, F. Moor
Journal: Gut (2011)

<h3>Introduction</h3> Coeliac disease (CD) is increasingly diagnosed in the elderly. The aim of the study was to determine the number of patients with CD diagnosed in later life, their mode of presentation and length of symptoms in a single centre 1958–2008. <h3>Methods</h3> The diagnosis of CD was based on characteristic appearances of small intestinal mucosa. Symptoms and length of history at presentation of CD were documented. Extensive efforts were made to identify all patients in the area served by the Derby hospitals. Sources of information included the hospital diagnostic index, histopathology records, dermatitis herpetiformis clinic, immunology laboratory, dietetic department and membership records of the Coeliac Society (Coeliac UK). Since 1978, patients were followed prospectively in a weekly CD clinic by GKTH. Information was stored on an Access data base. <h3>Results</h3> Between 1958 and 2008, 1315 patients with CD were diagnosed by small intestinal biopsy. Of these, 874 were female and 441 male giving an overall female to male ratio of 1.98:1. 377 (29%) were diagnosed over the age of 60 years; 265 (20%), 168 (13%), 93 (7%), 46 (3.5%), 9 (0.7%) and 1 (0.08%) were diagnosed over the ages of 65, 70, 75, 80, 85 and 90 years respectively. Of 265 patients diagnosed over the age of 65 years 127 (48%) had anaemia, 88 (33%) diarrhoea and 83 (32%) weight loss. 107 (40%) presented with non-specific symptoms or other complaints. 57 (22%) patients had anaemia alone and 20 (8%) diarrhoea alone. Of note only 57 cases (22%) presented with a combination of weight loss and diarrhoea and 22 (8%) a combination of weight loss, diarrhoea and anaemia. The average duration of symptoms prior to diagnosis was 40 months (spread 0–720 months). 44 and 32 patients experienced symptoms for over 60 and 120 months respectively, before diagnosis. <h3>Conclusion</h3> Almost one third of new diagnoses of CD are made in those over the age of 60 years. The diagnosis is easily missed because only a minority have combinations of weight loss, diarrhoea and anaemia regarded as typical symptoms of CD. Anaemia as the sole feature is found in a fifth of patients and diarrhoea may be the only symptom. 40% of cases have non-specific or other presentations. Diagnosis in the elderly is common but is often delayed because presentations may not immediately suggest the diagnosis of CD.
A Health Policy Agenda for the American People. Phase I: The principles
Authors: B. E. Balfe
Journal: JAMA (1985)

The growing complexity of the health care sector demands a comprehensive framework for the long-term direction of health care policy. To this end, a Health Policy Agenda for the American People was initiated in 1982. Phase I of this two-phase project ended in May 1984 and produced 159 principles and 41 issues covering a wide spectrum of health care concerns. During Phase II, presently under way, policy proposals are being developed that respond to these issues and are consistent with the principles. The principles constitute the basis for policy development and include statements about equity, individual and professional rights and responsibilities, the role of government, and the quality and cost of health care. In addition to their use in the development of the agenda, the principles are being used by participating organizations in their own policy development activities. (<i>JAMA</i>1985;254:2440-2448)
Osteopathic Training
Authors: Lee M. Adler
Journal: Annals of Internal Medicine (1978)

III. Comments1 November 1978Osteopathic TrainingLee M. Adler, D.O.Lee M. Adler, D.O.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-864_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe data in this Symposium having to do with annual totals of numbers of hospital admissions, outpatient visits, and physicians trained in infectious diseases may not include data from osteopathic institutions.The 1977 American Osteopathic Hospital Association survey of osteopathic hospitals reports that these 200 hospitals have a total of 24 006 adult and pediatric beds. The hospitals admitted 818 962 inpatients during 1977, of which 46.8% (383 588) were surgical admissions. The total number of live births in these hospitals was 52 804. Osteopathic hospitals provided care to 3 373 538 outpatients during 1977, or 12% of the annual... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Lee M. Adler, D.O.Affiliations: Chicago College of Osteopathic Medicine PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1978Volume 89, Issue 5_Part_2Page: 864-864KeywordsBirthInfectious diseasesInpatientsOutpatient clinics ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...
Intra-arterial barbiturate injection in a drug addict
Authors: I. Kott
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Reference was recently made to chronic otitis media, from which was recovered a culture of Escherichia coli (217:826, 1971), attributed to a urinary source. In a chronic tuberculosis service of years ago, chronic otitis media (painless) was common in patients with long-standing pulmonary cavitary disease. Recovery of tubercle bacilli might be difficult, but other organisms, especially<i>E coli</i>, were plentiful. While bacteremia may be implicated, a simple lack of fastidiousness would be adequate to explain this colonization.
Abnormal coronary vasomotion in response to acetylcholine predicts increased cardiac events in women: Data from the NHLBI-sponsored women's ischemia syndrome evaluation (WISE) study Greg O. von Mering, Carl J. Pepine, Susan P. McGorray, Dawn M. Miller, C. Noel Bairey Merz, Sheryl F. Kelsey, Nathaniel Reichek, Steven E. Reis, William J. Rogers, Barry L. Sharaf, George Sopko, Richard A. Kerensky. University of Florida College of Medicine, Gainesville, FL
Journal: Journal of the American College of Cardiology (2001)
Aminoaciduria
Authors: Mary L. Efron
Journal: New England Journal of Medicine (1965)

Disorders of Methionine MetabolismThe normal pathway of methionine metabolism is shown in Figure 3. Methionine has at least two major roles in addition to that in protein synthesis: it is the major methyl donor of the body and supplies methyl groups for synthesis of many compounds; and it is a precursor of cysteine and cystine. When there is a block in the metabolic pathway from methionine to cysteine, the plasma and urine cystine and taurine may be abnormally low.At least two inborn errors of methionine metabolism have been described thus far. They are named after the accumulated amino acid . . .
CAIUS OF GONVILLE AND CAIUS COLLEGE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction of Hyperplasia and Increased DNA Content in the Uterus of Immature Rats Exposed to Coumestrol
Authors: John Ashby, Helen Tinwell, Anthony Soames, John Foster
Journal: Environmental Health Perspectives (1999)

Administration of the phytoestrogen coumestrol to ovariectomized rats leads to increases in both wet and dry uterine weights in the absence of an increase in uterine DNA content, as reported by Markaverich et al. [Effects of Coumestrol on Estrogen Receptor Function and Uterine Growth in Ovariectomized Rats. Environ Health Perspect 103:574-581 (1995)]. It was not possible to know if the observed atypical uterotrophic response of coumestrol was associated uniquely with the ovariectomized uterotrophic assay protocol. This question is answered in the present paper. Two experiments are described in which three daily oral gavage administrations of 60 mg/kg/day coumestrol to immature AP rats were followed by assessment of the reproductive tract on the fourth day. In both experiments coumestrol increased uterine fluid content and increased the weights of the uterus, cervix, and vagina. In addition, bromodeoxyuridine staining of uterine sections enabled confirmation of uterine hyperplasia for the coumestrol-treated animals. In the second experiment, total uterine DNA was determined; it doubled in the coumestrol-treated animals. Estradiol benzoate acted as the positive control agent for both of these experiments, and in each case it gave similar responses to those seen for coumestrol. We conclude that the uterotrophic activity of the phytoestrogen coumestrol in the immature intact rat is typical of the activity of the natural estrogen estradiol.
What is a good death? Join in our online discussions
Journal: BMJ (2003)

Public awareness campaigns can help overcome some of these issues, while also promoting active and healthy lifestyles.Outreach programmes also are a valuable supplement to clinic based services for older women.Community based activities, including support groups and volunteer health promoters, hold special promise since they can maximise the interest and resources of the elderly themselves as well as the wider community.No matter which interventions are selected, expanding services for older women will place new demands on healthcare providers.Providers should receive pre-service and refresher training to learn how to counsel women and treat common health problems.Equally important, educational programmes should aim to change providers' attitudes so that they value older clients.Following the lead of international agencies and local programmes, the global health community must work to address the health needs of older women, especially in the world's poorest countries.
Current gastroenterology
Authors: L A Turnberg
Journal: Gut (1983)

Diagnosis of oesophageal spasm by ergometrine provocation Sir,We have recently published our findings on oesophageal spasm and the value of ergometrine provocation in its diagnosis (Gut 1982; 23: 89-97).We misquoted figures from Buxton's study and reported three patients who died with coronary artery spasm after a dose of ergometrine which was 0 17 mg and not 1.7 mg as stated in our paper.Our recommendation, however, to give 0.5 mg of ergometrine is safe provided that the screening criteria are followed.These should include a normal 12-lead ECG obtained during spontaneous chest pain, and resuscitative facilities should be available during the ergometrine test.Responses to small doses of ergometrine -0.05 mg should first be assessed and after five minutes, incremental doses can then be given.
Nosocomial gram-negative bacillary parotitis
Authors: T. L. Pruett
Journal: JAMA (1984)

Historically,<i>Staphylococcus aureus</i>has been the primary pathogen in acute suppurative parotitis (ASP). This report presents an index case of<i>Pseudomonas aeruginosa</i>bacteremia assocated with ASP and an institutional review of parotitis in which three of 23 additional cases of pyogenic parotitis had enteric bacilli cultured either alone or as the primary pathogen. These cases support the previously undocumented supposition that enteric gram-negative bacilli and pseudomonads can be pathogens in ASP. (<i>JAMA</i>1984;251:252-253)
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions
Authors: Jinhong Wu, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, Loretta G. Que, W. Michael Foster, Zhenwei Xia, Hongbo Chi, Xiao-Ping Zhong
Journal: Journal of Clinical Investigation (2017)
ADDRESS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-κB in adult T-cell leukemia/lymphoma
Authors: M V P Nadella, W P Dirksen, K S Nadella, S Shu, A S Cheng, J A Morgenstern, V Richard, S A Fernandez, T H Huang, D Guttridge, T J Rosol
Journal: Leukemia (2007)
Re: Maarten de Rooij, Simone Crienen, J. Alfred Witjes, Jelle O. Barentsz, Maroeska M. Rovers, Janneke P.C. Grutters. Cost-effectiveness of Magnetic Resonance (MR) Imaging and MR-guided Targeted Biopsy Versus Systematic Transrectal Ultrasound–guided Biopsy in Diagnosing Prostate Cancer: A Modelling Study from a Health Care Perspective. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2013.12.012
Authors: Sarah Willis, Alec Miners, Jan van der Meulen
Journal: European Urology (2014)
LONGEVITY OF PHYSICIANS.
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ambiguous external genitalia in the newborn and prepubescent child
Authors: W. P. Dmowski
Journal: JAMA (1970)

The sexual makeup of an individual consists of several components both physical and psychological in nature. In the normal being, male or female, all characteristics are expected to be of one gender, harmonious with the chromosomal pattern established in the zygote at the time of fertilization. However, the bisexual potential inherent in everyone may result in the emergence of abnormalities both physical and psychological. Aberrations at any of the stages of development may thus result in the incomplete or faulty differentiation of the particular component and sexual ambiguity. Ambiguous external genitalia is not a syndrome per se, but manifestation of abnormal development common to many disorders. The occurrence is approximately one in every 30,000 newborns. Despite its relative rarity, this condition carries several serious implications and requires careful evaluation when observed neonatally or in the prepubescent child. <h3>Embryogenesis of External Genitalia</h3> External genitalia originate from the same primordial structures in
Standard Forms for References: Additional Journals
Authors: E.J. H.
Journal: Annals of Internal Medicine (1970)

Editorial Notes1 July 1970Standard Forms for References: Additional JournalsE.J. H.E.J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-1-136 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn January the ANNALS and other American journals announced the adoption of a uniform style for bibliographic references (1). This original group comprised 18 journals in clinical and investigative medicine. Since then, nine more journals have adopted this bibliographic style:The American Journal of GastroenterologyAnnals of Otology, Rhinology and LaryngologyIndustrial Medicine and SurgeryJournal of Laboratory and Clinical MedicineJournal of the Louisiana State Medical SocietyJournal of TraumaMayo Clinic ProceedingsPhysical TherapySouthern Medical JournalInquiries have come from other possible users, and we shall list their names if they join the present group....Reference1. HUTH E: Standard forms for references. Ann Intern Med 72:140-141, 1970 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1970Volume 73, Issue 1Page: 136-136KeywordsClinical laboratoriesOtologyResearch laboratoriesRhinologyTrauma surgery Issue Published: 1 July 1970 PDF downloadLoading ...
Short-Term Improvement in Schizophrenia: The Contribution of Background Factors
Journal: American Journal of Psychiatry (1968)

Three categories of background factors were found to predict short-term improvement (symptom reduction) in schizophrenic patients receiving either placebo or one of three phenothiazines: general predictors, which applied equally to all treatments; predictors of outcome under placebo but not under drug treatment, or vice versa; and predictors of outcome under one phenothiazine but not another. Some variables found by other investigators to predict outcome were not found to be predictors in this study; it is suggested that these variables are not related to the specific outcome measure of symptom reduction.
Functional Somatic Syndromes
Authors: Thomas L. Kurt
Journal: Annals of Internal Medicine (2000)

Letters15 February 2000Functional Somatic SyndromesThomas L. Kurt, MD, MPHThomas L. Kurt, MD, MPHUniversity of Texas Southwestern Medical Center; Dallas, TX 75235 (Kurt)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-4-200002150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I am a medical toxicologist involved in case–control investigations of Gulf War veterans who were identified by epidemiologic risk clusters and in animal modeling studies. I wish to challenge the inclusion of “Gulf War syndrome” by Barsky and Borus among their functional somatic syndromes (1). By two-stage factor analyses of symptom clusters in Gulf War veterans, we found three major and three minor syndrome variants, not just a single syndrome (2). The major syndrome variants were determined to correlate with three different binary drug-chemical exposure combinations (3). Parallel animal modeling studies further substantiated that these binary drug-chemical ...References1. Barsky AJ, Borus JF. Functional somatic syndromes. Ann Intern Med. 1999;130:910-21. LinkGoogle Scholar2. Haley RW, Kurt TL, Hom J. Is there a Gulf War syndrome? Searching for syndromes by factor analysis of symptoms. JAMA. 1997;277:215-22. CrossrefMedlineGoogle Scholar3. Haley RW, Kurt TL. Exposure to neurotoxic chemical combinations in the Gulf War: cross-sectional epidemiologic study. JAMA. 1997;277:231-7. CrossrefMedlineGoogle Scholar4. Abou-Donia MB, Wilmarth KR, Abdel-Rahman AA, Jensen KF, Oehme FW, Kurt TL. Increased neurotoxicity following simultaneous exposure to pyridostigmine bromide, DEET and chlorpyrifos. Fund Appl Toxicol. 1996;34:201-22. CrossrefMedlineGoogle Scholar5. Haley RW, Hom J, Roland PS, Bryan WW, Van Ness PC, Bonte FJ, et al . Evaluation of neurologic function in Gulf War veterans: a blinded case–control study. JAMA. 1997;277:223-30. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas Southwestern Medical Center; Dallas, TX 75235 (Kurt) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFunctional Somatic Syndromes Arthur J. Barsky and Jonathan F. Borus Functional Somatic Syndromes Arthur J. Barsky and Jonathan F. Borus Functional Somatic Syndromes Terry E. Hedrick Functional Somatic Syndromes James McSherry Functional Somatic Syndromes Kenneth Clemenger Functional Somatic Syndromes Allan Clemenger Functional Somatic Syndromes Ellen Goudsmit Functional Somatic Syndromes Melody Heard Functional Somatic Syndromes Frank Albrecht Functional Somatic Syndromes Thomas L. English Metrics 15 February 2000Volume 132, Issue 4Page: 329KeywordsAnimal modelsDrugsEpidemiologyFactor analysisFatsNeuropsychological testingPostural controlRespirators ePublished: 15 August 2000 Issue Published: 15 February 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...