tbuckley/cabot-search huggingface dataset:
Herpetic Chancre
Authors: Te-Wen Chang
Journal: JAMA (1973)

<h3>To the Editor.—</h3> A case of solitary penile ulcer was found to be due to a combined infection by<i>Treponema pallidum and Herpesvirus hominis</i>. Although herpes progenitalis and syphilitic chancre may develop in one patient simultaneously, their occurrence together in a single lesion is uncommon. A search of literature has failed to reveal such a description. The following is a case of combined infection with<i>H hominis and T pallidum</i>occurring in the form of a single penile ulcer. <h3>Report of a Case.—</h3> A 30-year-old unmarried restaurant worker appeared with a penile lesion of 13 days' duration. He had had repeated sexual exposures earlier. The lesion started as a cluster of three tiny vesicles that rapidly broke and coalesced into a single ulcer. The unusual feature was the absence of pain, itching, or dysuria. A shallow and sharply demarcated 0.5 × 1.5 cm indurated nontender ulcer was seen over the
Chemical Laboratory Manual.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL COLLEGE "NOTES AND COMMENTS."
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HBO can interact with preexisting patient conditions
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DENTAL DISPENSARIES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Y chromosome and primary sexual differentiation
Authors: R. Bernstein
Journal: JAMA (1981)

The mammalian Y chromosome plays a dominant role in initiating fetal testicular differentiation. Testicular differentiating genes on the Y chromosome can be serologically detected as H-Y antigen. The correlation of numerical and structural abnormalities of the X and Y chromosomes, combined with H-Y antigen reactivity, gonadal histology, and phenotype, has contributed to mapping the locus of these genes on the Y chromosome and has elucidated some of the mechanisms responsible for anomalous primary sexual differentiation. The causes for failure of gonadal differentiation despite the presence of a Y chromosome or for testicular differentiation in the absence of a detectable Y are discussed. Evidence is presented for genes on the X chromosome that regulate the activity of testicular differentiating genes on the Y chromosome. (<i>JAMA</i>1981;245:1953-1956)
"MEDICINE A HUNDRED YEARS AGO"
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A cluster of patients with a chronic mononucleosis-like syndrome. Is Epstein-Barr virus the cause?
Authors: G. P. Holmes
Journal: JAMA (1987)

A cluster of 134 patients who had undergone Epstein-Barr virus (EBV) serological testing because of suspected chronic EBV syndrome was investigated in Nevada. Fifteen case-patients were identified who had severe, persistent fatigue of undetermined etiology for more than two months. When compared with the remaining 119 patients who had less severe illnesses and with 30 age-, sex-, and race-matched control-persons, these 15 patients had significantly higher antibody titers against various components of EBV and against cytomegalovirus and herpes simplex and measles viruses. Epstein-Barr virus serology could not reliably differentiate individual case-patients from the others, and the reproducibility of the tests within and among laboratories was poor. As a group, the case-patients appear to have had a syndrome that is characterized by chronic fatigue, fever, sore throat, and lymphadenopathy. The relationship of this fatigue syndrome to EBV is unclear; further studies are needed to determine its etiology. (<i>JAMA</i>1987;257:2297-2302)
Aide-memoire for preparing clinical trial protocols.
Authors: T Kroner, A Tschumi
Journal: BMJ (1977)

to damage by cytotoxic drugs.A study of childhood-cancer survivors, however, showed no evidence of a raised rate of spontaneous abortions or malformations in the progeny of men after treatment with various cytotoxic agents.'On the other hand, a recent report has described two cases of severe malformations after chemotherapy for acute myelogenous leukaemia in two men.'In our case the lack of malformations in the child born after the second pregnancy is noteworthy as the father had been treated with MTX and 6-MP at the time of conception for over one and a half years.Both drugs are known to carry a definite teratogenic risk in the mother.'In view of the considerable rate of spontaneous abortions in the general population, it is not possible to decide whether the previous abortion was due to a mutagenic effect of the chemotherapy, was otherwise related to the malignancy, or was purely coincidental.The improvements in chemotherapy have led to increasing numbers of young long-time survivors of malignant disease.These patients often seek information about the risk to the fetus in case of a preg- nancy.To obtain data for better counselling more reports about the outcome of such pregnancies are needed.
Book Review Urology in War: Wounds and other emergencies of the genito-urinary organs, surgical and medical . By Lieutenant Commander Charles Y. Bidgood (MC), U.S.N.R. 8°, cloth, 78 pp., with 27 illustrations and 3 tables. Baltimore: The Williams and Wilkins Company, 1942. $2.00.
Journal: New England Journal of Medicine (1943)
Analysis of PNPLA3 SNP variants in human hepatic stellate cells in 3D human liver extracellular matrix scaffolds reveals key PNPLA3-dependent pro-fibrogenic features
Authors: Elisabetta Caon, Ana Levi, Dong Xia, Leo Ghemtio, Kessarin Thanapirom, Walid Al-Akkad, Giuseppe Mazza, Massimo Pinzani, Krista Rombouts
Journal: Journal of Hepatology (2020)
First results of a phase III multicenter randomized controlled trial of intensity modulated (IMRT) versus conventional radiotherapy (RT) in head and neck cancer (PARSPORT: ISRCTN48243537; CRUK/03/005)
Authors: C. Nutting, R. A'Hern, M. S. Rogers, M. A. Sydenham, F. Adab, K. Harrington, S. Jefferies, C. Scrase, B. K. Yap, E. Hall
Journal: Journal of Clinical Oncology (2009)

LBA6006 Background: Xerostomia is the most common late toxicity of RT to the head and neck. IMRT dose distributions reduce the dose delivered to parotid gland. PARSPORT investigated the role of IMRT in reducing xerostomia in patients with head and neck cancer. Methods: The PARSPORT trial compared two radiotherapy delivery methods in the treatment of patients with pharyngeal tumors (T1–4, N0–3, M0). Patients received 65Gy in 30 fractions over 6 weeks delivered using either CT planned parallel opposed lateral fields or parotid-sparing IMRT. Stratification was by site of tumor and center. The primary endpoint was incidence of LENT-SOMA ≥G2 xerostomia one year after treatment. Secondary endpoints included acute toxicities (CTCAE v3) and other late RTOG and LENT-SOMA radiation toxicities. Proportions of patients with ≥G2 toxicity were compared using exact tests. For secondary endpoints a significance level of 1% was used. Results: 94 patients (47 RT; 47 IMRT) were randomized between 2003 and 2007 from six UK centers. 80 patients had oropharyngeal tumors and 14 hypopharyngeal. Radiotherapy was given as primary treatment in 71 patients and post-operatively in 23. 22 patients had AJCC stage I/II disease. Median follow-up was 31.9 months (IQR: 26.6 –38.8). Twelve month LENT-SOMA ≥G2 xerostomia scores were observed in 74% (25/34) of RT and 40% (15/38) of IMRT patients (p=0.005). Corresponding values at 18 months were 71% (15/21) and 29% (9/31) (p=0.004). On the RTOG scale, 12 month ≥G2 xerostomia was reported in 64% (21/33) RT vs 41% (15/37) IMRT patients (p=0.06). The 18 month incidence was 81% 17/21 RT vs 20% (6/30) IMRT (p&lt;0.001). Acute radiotherapy related ≥G2 fatigue was more prevalent in the IMRT group (76% vs 41% p=0.001). No differences in acute mucositis or pain scores were seen. At 12 months, no statistically significant differences were seen in other late toxicities. No differences were observed between overall survival and locoregional control rates. Conclusions: Sparing the salivary glands through use of IMRT significantly reduces the incidence of xerostomia in patients with pharyngeal tumors. [Table: see text]
Certain Aspects of Allergy in Children
Authors: Lewis Webb Hill
Journal: New England Journal of Medicine (1961)

EczemaEpstein36 is of the opinion that sluggish bacterial infection plays an important part in some eczemas even though no gross signs of infection such as pustulation are present. These are called "infectious eczemas." In some cases bacterial infection and sensitization to bacteria are primary causes; in others secondary infection is superimposed on an existing eczema. Once eczematous sensitivity to bacteria has developed, all that is seen is usually a "dermatitis," and one may only suspect the infectious factor. The demonstration of staphylococcus or streptococcus proves nothing, for they are found in most eczemas. Sometimes, the use of antibiotics by . . .
Surgical Delusions and Follies.
Authors: None E. W. A.
Journal: JAMA (1884)

This is a clever address which the author delivered before the Medical Society of the State of Pennsylvania. Without professing to go deep into scientific questions, he discusses here many minor superstitions and errors which cling about surgical practice, much in the spirit of the immortal author of "Don't." It is doubtless true that in the routine of minor surgery more absurd and antique delusions are still in vogue than in most modern specialties. It is also true that some good physicians, who do only occasionally any surgical work, are the most hide-bound in their prejudices, and need a thorough shaking up before they will let go old notions and adapt their surgery to the present day. This little volume is both suggestive and profitable to all who look over its pages.
Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)—Correction
Journal: JAMA (2003)

Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic
Serum-therapy.
Authors: Carl Strueh
Journal: JAMA (1896)

Chicago, Oct. 31, 1896. <h3>To the Editor:</h3> —In the last issue of theJournalI find a short letter referring to and criticising Dr. H. Lahmann's article on serum-therapy. As Dr. Lahmann will hardly become acquainted with the contents of this letter, I think it my duty to reply to it in his stead, because it was I who translated his article for theJournal. In consideration of the fact that every serum-treatment so far employed has proven to be a failure, and considering also that the efficiency of the antitoxin treatment of diphtheria is still either doubted or denied by a great many competent physicians, it seems to be quite a bold undertaking by any advocate of the serum-therapy to call a physician whose therapeutic views differ from his, a quack. In concluding his letter Dr. K. says: "We should be on our guard, having enough of the sort
Myocarditis in Mycoplasma pneumoniae Pneumonia
Authors: M. Riad El Khatib
Journal: JAMA (1975)

INFECTIONS with<i>Mycoplasma pneumoniae</i>have infrequently been associated with myopericarditis.<sup>1</sup>We recently treated a 20-year-old college student with severe<i>M pneumoniae</i>pneumonia involving four lobes of the lungs. In the third week of his illness, he developed myopericarditis requiring coronary unit care. Simultaneously, hemolysis and unprecedented high titers of cold hemagglutinins occurred. <h3>Report of a Case</h3> A 20-year-old college student became ill on Nov 15, 1973. Symptoms included headache, fever, chills, pleurisy, and nonproductive cough. Chest x-ray film showed bilateral pneumonia involving right upper and middle and both lower lobes. He was admitted to Cottage Hospital in Grosse Pointe, Mich. Hemoglobin value was 14.2 gm/100 ml, and white blood cell (WBC) count was 4,900/cu mm, with a shift to the left and toxic granules within neutrophils. Although the patient received a variety of antibiotics (penicillin G potassium, ampicillin sodium, carbenicillin disodium, and gentamicin sulfate), his condition did not improve.
A surgical pilgrimage. Some current-day problems of surgical education. Every man his own Boswell
Authors: O. H. Wangensteen
Journal: JAMA (1968)

What is surgery? Many are inclined to define surgery as a mode of therapy, and, in a sense, every discipline of clinical medicine could be so defined. As medicine emerged from the myths of superstition into an art reflecting insight, interpretability, and understanding, the breadth of medicine enlarged to include probing of the causes of disease as well as the likely outlook of diseased states. When medicine assumed aspects of a science, progress was accelerated by analyzing the successes and failures of past empiricism. Scientific inquiry fostered the birth of many new disciplines, a germinal fecundity which continues to make an accelerating impact upon medicine's advance. Though it is no longer possible, therefore, to label any discipline of medicine as merely a form of therapy, some in the present hierarchy of medicine, yes even within the sanctums of curricular committees, continue to insist that surgery is only that. It is
Points: Is the flow rate used to drive a jet nebuliser clinically important?
Authors: I. W B Grant
Journal: BMJ (1985)

ments committees, grant awarding bodies, etc, are more impressed by the quantity than by the quality of published work.Unfortunately, the medical profession can- not seek guidance in proper behaviour from the scientific community, whose morals are questioned because of duplication and fraud.2Among so called pure scientists the ethic of "publish or perish" seems even more revered.Only when it is agreed that scientific communications are intended to further knowledge, rather than careers or egos, will we reach the peak of the present, senseless, exponential
Predetermined Dosimetry of Inhaled Particles in Man
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rigid Enforcement of Immigration Laws.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemagglutination-inhibiting antibodies in vaccinated children with renal disease
Authors: K. J. Sheth
Journal: JAMA (1979)

One year after immunization with a single 0.5-mL dose of influenza virus vaccine, serum samples from 30 children with renal diseases were tested for serum hemagglutination-inhibiting (HI) antibody titers to A/New Jersey/76, A/Victoria/75, and A/USSR/77. Eleven unvaccinated children with renal diseases formed a comparison group. In contrast to the comparison group (0/11), 53% (16/30) of the vaccinated group had a protective level of serum HI titers (≥1:40) against A/New Jersey. A protective level of serum HI titer against A/Victoria was noted in 83% (25/30) of the vaccinated group, while 54% (6/11) of the unvaccinated group had similar HI titers. None had a detectable HI titer against A/USSR. A minor common cold-like illness occurred in seven of the 30 vaccinated children; one of these had exacerbation of nephrotic syndrome. The data suggest a good protection against influenza one year after vaccination in children with renal disease. (<i>JAMA</i>242:1752-1754, 1979)