tbuckley/cabot-search huggingface dataset:
Commentary: Accuracy of Computed Tomographic Angiography and Magnetic Resonance Angiography for Diagnosing Renal Artery Stenosis
Authors: Harold C. Sox
Journal: Annals of Internal Medicine (2004)

Commentary2 November 2004Commentary: Accuracy of Computed Tomographic Angiography and Magnetic Resonance Angiography for Diagnosing Renal Artery StenosisHarold C. Sox, MD, EditorHarold C. Sox, MD, EditorSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-9-200411020-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The principal claim of this carefully done study is that CTA and MRA miss too many cases of renal artery stenosis to be the tests of choice. The purpose of this commentary is to test this claim by translating the sensitivity and specificity into a term that clinicians can use for decision making: the likelihood ratio. Remember that the post-test odds equals the pretest odds times the likelihood ratio. The likelihood ratio, therefore, tells us how much a test result changes the odds of disease. The Table in this commentary shows likelihood ratios calculated from the authors' Table 3.Table. ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAccuracy of Computed Tomographic Angiography and Magnetic Resonance Angiography for Diagnosing Renal Artery Stenosis G. Boudewijn C. Vasbinder , Patricia J. Nelemans , Alfons G.H. Kessels , Abraham A. Kroon , Jeffrey H. Maki , Tim Leiner , Frederik J.A. Beek , Michael B.J.M. Korst , Karin Flobbe , Michiel W. de Haan , Willem H. van Zwam , Cornelis T. Postma , M. G. Myriam Hunink , Peter W. de Leeuw , Jos M.A. van Engelshoven , and Metrics Cited byLiteraturRenal Artery Assessment with Nonenhanced Steady-State Free Precession versus Contrast-enhanced MR AngiographyRenovascular disease imaging: Today more than ever the invasive cardiologist may make the differenceAssessing the appropriateness and increasing the yield of renal angiography in patients undergoing coronary angiography: a scoring systemHigh-Spatial-Resolution MR Angiography of Renal Arteries with Integrated Parallel Acquisitions: Comparison with Digital Subtraction Angiography and US 2 November 2004Volume 141, Issue 9Page: 682KeywordsAngiographyAngioplastyComputed axial tomographyDecision makingHypertensionLikelihood ratioMagnetic resonance angiographyRenal arteriesSpecificityStenosis ePublished: 2 November 2004 Issue Published: 2 November 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
GAS CYSTS OF THE INTESTINES
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Salivary Transcriptome
Authors: David T. Wong
Journal: Clinical Cancer Research (2007)

To the Editors:The recent article by Kumar et al. (1) in the September 1, 2006 issue of Clinical Cancer Research challenged the presence of salivary mRNA. They concluded that the source of the published RNA signals detected in human saliva is from genomic DNA contamination. This letter provides a different perspective on this subject and rebuts the investigators' conclusion.The major discrepancy is the claim by these investigators (1) that they have reproduced the experimental conditions of the Li et al. article (2) without detecting mRNA. A careful comparison of the two articles shows that there are significant differences. First and foremost, Kumar et al. used RNAlater (Ambion Inc., Austin, TX) to stabilize salivary RNA, whereas Li et al. used Superase-In (Ambion, Inc., Austin, TX), a protein-based inhibitor efficient in inhibiting different types of nucleases, including RNase A, B, C, 1, and T1. Other than inhibiting nucleases, it has no additional effect in saliva. RNAlater, on the other hand, does a lot more than just preserving RNA. RNAlater increases cellular membrane permeability and its high salt content (ammonium sulfate) changes intracellular salt concentration, leading to leakage of cellular components, including genomic DNA. We have recently compared a number of RNA stabilizers and found RNAlater to be the least suitable, even worse than without any stabilizer (3).Second, the methods used by the Kumar et al. cannot isolate RNA from saliva, not even from the cellular pellet. The failure to isolate RNA from the saliva cell pellet should signal concerns as it is enriched in epithelial cells and leukocytes, which often serve as an internal positive control for RNA isolation. The investigators used a different RNA isolation procedure than the one published by Li et al. (2). The failure to isolate RNA from the saliva cellular pellet suggests the inability of their procedure to harvest RNA from saliva.The scientific credibility of the salivary transcriptome is increasing, ranging from recent studies on the characterization of salivary RNA (4), to assessing salivary RNA integrity by cDNA library analysis (5), to identifying and commercializing the most effective stabilizer, RNA Protect Saliva (QIAGEN, Valencia, CA) for research and eventual clinical applications (3). The salivary cDNA library analysis conclusively showed that none of the detected mRNA in saliva is from a pseudogene of contaminating genomic origin, independently disputing DNA as a source of templates giving rise to false-positive RNA signals (5). Other research groups, particularly from forensic sciences, are focusing on multiplex mRNA profiling for the identification of body fluids, including saliva (6–9). The most recent study from Seugnet et al. compellingly shows the value of the amylase mRNA in human saliva as a highly discriminatory biomarker for sleep drive (10).
Familial isolated hypoparathyroidism caused by a mutation in the gene for the transcription factor GCMB
Authors: Changlin Ding, Bruce Buckingham, Michael A. Levine
Journal: Journal of Clinical Investigation (2001)

Hypoparathyroidism is characterized by hypocalcemia, hyperphosphatemia, and absent or markedly reduced circulating concentrations of parathyroid hormone. The transcription factor GCMB is predominantly, if not exclusively, expressed in parathyroid cells and is critical for development of the parathyroid glands in mice. Thus, in the present study we examined the GCMB gene, mapped to 6p23–24, as a candidate for isolated hypoparathyroidism. We defined the boundaries of the five exons of the human GCMB gene and then identified a large intragenic mutation in the GCMB genes of the proband of an extensive kindred with isolated hypoparathyroidism. Her parents and several other unaffected relatives were heterozygous for the mutation. Despite an absence of any history of consanguinity, microsatellite analysis showed shared genotypes that flanked the GCMB gene over a span of 5 cM, suggesting that both of the proband's GCMB alleles had been derived from a single common ancestor. Analysis of additional, unrelated cases did not disclose the same mutation. We conclude that homozygous loss of function of the GCMB gene impairs normal parathyroid gland embryology and is responsible for isolated hypoparathyroidism in a subset of patients with this disease.
Delayed‐type hypersensitivity and circulating basophils: A population study
Authors: M. Chavance, B. Herbeth, B. Lesourd
Journal: Allergy (1991)

The factors related to delayed‐type hypersensitivity (DTH) have been investigated in two samples of elderly non‐hospitalized ( n = 375) and hospitalized subjects ( n = 409). Percent basophils was found to be consistently related to the number of positive responses to seven common antigens in the different samples or subsamples considered. The mean number of responses, after adjustment for age, sex and sample was 1.55 below 0.5% basophils, 1.87 between 0.5 and 1.5% and 1.96 over 1.5% ( P &gt; 0.01). No relation was observed between percent basophils and the mean diameter of the positive responses, suggesting that basophils might be related to the early phase of DTH reactions. As previously reported, the number of positive responses was found to be lower in women than in men and to be inversely related to age.
THE ABUSE OF PROPRIETARY MEDICINES.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ALS Trials Prove Encouraging
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Economics.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psycho-Analysis Today: Its Scope and Function.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diencephalic and cerebellar pathology in alcoholic and nonalcoholic patients with end-stage liver disease
Authors: J Kril
Journal: Hepatology (1997)

Formalin-fixed sections from the brains of 36 patients (30 alcoholic and 6 nonalcoholic) with autopsy-proven cirrhosis who died while in a hepatic coma were stained with hematoxylin and eosin, and examined for the presence of diencephalic, cerebellar, pontine, and basal ganglia lesions. Significant neuropathology was identified in 23 of 36 cases consisting of mammillary body and thalamic lesions characteristic of Wernicke encephalopathy (WE) (9 cases, all alcoholic patients) and cerebellar degeneration (20 cases, 17 alcoholic and 3 nonalcoholic patients). Clinical diagnosis of WE had been entertained during life in only 2 of these patients. All cases, alcoholic and nonalcoholic, manifested mild to severe Alzheimer's type II astrocytosis. No cases of central pontine myelinolysis nor acquired (non-Wilsonian) hepatocerebral degeneration were found. These findings show that the brains of a high proportion of cirrhotic patients with end-stage liver disease manifest concomitant unsuspected diencephalic and cerebellar pathology. The high incidence of WE underscores the need for early sustained treatment of alcoholic cirrhotic patients with vitamin B1. Evaluation of the neurological sequelae of liver transplantation, particularly of alcoholic patients with end-stage liver disease, may require a careful neurological and radiological assessment both before and after surgery.
Disseminated sporotrichosis in a patient with HIV infection after treatment for acquired factor VIII inhibitor
Authors: M. R. Bibler
Journal: JAMA (1986)

SYSTEMIC sporotrichosis is a rare but well-recognized opportunistic fungal infection, usually occurring in patients with hematological or lymphoreticular malignant neoplasms, alcohol abuse, long-term high-dose steroid treatment, or diabetes mellitus.<sup>1-3</sup>We describe a woman who became infected with human immunodeficiency virus ([HIV], formerly denoted human T-lymphotropic virus type III/lymphadenopathy-associated virus) following transfusion therapy for an acquired factor VIII inhibitor and who developed disseminated cutaneous sporotrichosis three years later. <h3>Report of a Case</h3> A 71-year-old woman was initially seen in March 1986 with a four-month history of progressive fatigue, weight loss, fever, and multiple enlarging cutaneous ulcers. More recently she had also noted night sweats, nonproductive cough, left shoulder pain, and painless right ankle swelling. Three years before admission to the hospital, in December 1982, gross cutaneous hemorrhage developed, and she was found to have an acquired factor VIII inhibitor of high titer (25 Bethesda units) with a residual plasma factor
Multiple Candida Abscesses Resulting from Insulin Injections
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poetry and Medicine
Authors: Jon Mukand
Journal: JAMA (1989)

"Black Lightning" by Arthur Sze originally appeared in Despite This Flesh (Austin: University of Texas Press; 1986) and is reprinted by permissionn of the poet. The poem is included in Mukand J, ed: Sutured Words: Contemporary Poetry About Medicine (Brookline, Mass: Aviva Press [PO Box 1357]; 1987).
20 years after first human heart transplant, 1987 may see 4000 procedures performed worldwide
Authors: K. S. Raithel
Journal: JAMA (1987)

THIS WEEK marks the 20th anniversary of the first human heart transplant (<i>JAMA</i>1967;202:23-24). Christiaan N. Barnard, MD, PhD, the surgeon who performed that transplant, recalled in a recent interview the events leading up to the historic operation. Cardiac transplantation to Barnard was merely a "new surgical technique." He began to think human heart transplants might be feasible when he read of a technique in 1959 in which the posterior walls of the recipient's atria were left behind. "Immediately, cardiac transplantation became a very straightforward surgical technique because it meant that you didn't have to anastomose the two vena cavae and the four pulmonary veins—all you had to anastomose were the two atria," he says. After studying for several months in the United States, Barnard, who is currently a scientist-in-residence at the Oklahoma Transplantation Institute, Baptist Medical Center, Oklahoma City, returned to South Africa ready to begin the patient-selection process.
Paradoxical diarrhea with opiates
Authors: R. A. Cohen
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The medical profession has literally been "blessed with the fruits" of the unripe seed capsule of the opium poppy,<i>Papaver somniferum</i>, for thousands of years. It has also been plagued with the problem of patients in search of relief from severe diarrhea. The pharmacologically active constituents of opium have been found to be an effective mode of therapy in exhausting diarrheal states, ie, acute dysentery. It is not surprising, therefore, that opium and diarrhea should meet and form an intimate relationship. It is the purpose of this paper to present two cases of chronic diarrhea, which occurred during long term tincture of opium therapy, that were markedly decreased with discontinuation of the drug. <h3>Case 1.—</h3> A 34-year-old white man was seen at the UCLA Medical Center in 1968, because of a five-year history of cramping pain and watery diarrhea. In 1963 a resection of six feet of
HYPOXIA AND THE SOLDIER
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The major risk factor for late thrombosis following gamma radiation for in-stent restenosis in new stent use Richard E. Kuntz, Paul S. Teirstein, Kalon K. L. Ho, Brian J. Firth, Steven J. Ellis, David Fish, James B. Hermiller, Prabhakar Tripuraneni, Shirish Jani, Martin B. Leon. Brigham and Women's Hospital, Boston, Lenox Hill Hospital, New York
Journal: Journal of the American College of Cardiology (2001)
Progression of renal disease in Henoch-Schonlein purpura after influenza vaccination
Authors: J. Damjanov
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Different skin lesions have been described in primary amyloidosis, including papules, nodules, bullae, plaques, and hemorrhages, which are usually petechial but occasionally more extensive.<sup>1,2</sup>Purpuric lesions seen in systemic amyloidosis often involve the face and neck, particularly the upper eyelids. The following is a case with striking periorbital purpura that developed after percutaneous renal biopsy. <h3>Report of a Case.—</h3> A 75-year-old man was referred with complaints of dysphagia, fatigue, weakness, inappetentia, and a weight loss of 15 kg in a period of four months. Physical examination results were unremarkable except for pitting ankle edema, muscle wasting, and orthostatic blood pressure drop (from 110/70 to 95/60 mm Hg). The electrophysiological studies (motor nerve conduction velocity) showed peripheral neuropathy. Routine urinalysis disclosed 4± protein with hyaline and granular casts. The 24-hour urine protein level was 2.1 g. The serum protein level was 5.2 g/dL; albumin, 2.8 g/dL; creatinine,