tbuckley/cabot-search huggingface dataset:
The Diagnosis and Treatment of Venereal Diseases in General Practice.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minimizing the impact of intestinal surgery
Authors: P. Gunby
Journal: JAMA (1981)

Efforts are increasing to make life as normal as possible for patients who require surgical removal of diseased portions,of the alimentary tract. Studies on ileoanal anastomosis and ileostomy occluding devices are under way at the Mayo Clinic and elsewhere. At Mayo, a "resurrected technique" used in the 1940s in Europe and the United States is now being used for some patients. Colonic disease limited to the mucosa is treated by colectomy, mucosal proctectomy, and endorectal-ileal pull-through with preservation of the anal sphincter (<i>Surg Gynecol Obstet</i>1947;84:1095-1099). Surgical resident Jacques Heppell, MD, who under a Canadian Medical Research Council grant is working with Keith A. Kelly, MD, explains that continence is related not only to good sphincter function but also to the reservoir capacity of the rectum. The hypothesis is that, after such surgery, the terminal ileum can dilate secondary to chronic intermittent occlusion by sphincter contraction. The sphincter pressure that
THE PROBLEM OF WATER PURIFICATION.
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA's Science Reporters Conference focuses on contraception and prevention of premature birth
Authors: A. A. Skolnick
Journal: JAMA (1996)

THE 15th Annual Science Reporters Conference of the American Medical Association (AMA), held in San Francisco, Calif, focused in large part on women's health issues. One morning of the 3-day conference was devoted to presentations that were simulcast via satellite to news reporters in New York, NY. Two of the 3 presentations concerned what patients need to know about birth control options; the third addressed strategies that can help reduce health problems and costs associated with premature birth. Before the investigators spoke, Timothy T. Flaherty, MD, a member of the AMA's Board of Trustees, introduced the Association's new consumer book,<i>American Medical Association Complete Guide to Women's Health</i>(New York, NY: Random House Inc; 1996), edited by Ramona I. Slupik, MD. More than 30 specialists contributed to making the guide the most thorough and up-to-date source of information on health concerns of women of all ages, Flaherty said. <h3>Preventing Unwanted</h3>
CLOT-BEGOTTEN BLEEDING IN VIRAL DISEASE
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of renal scars in children: missed opportunities in management. South Bedfordshire Practitioners' Group.
Journal: BMJ (1990)

To assess the antecedent medical care of children with renal scars.Retrospective study of both general practice and hospital records.12 Group practices in south Bedfordshire and the radiology and paediatric outpatient departments of a district general hospital.23 Children with renal scars (six boys, 17 girls) from the 12 group practices, identified from outpatient, radiology, and general practice records.Number of children in whom a diagnosis of urinary tract infection had been made without prior examination of a mid-stream specimen of urine; number of children who had had a confirmed urinary tract infection that had not been investigated further; number who had experienced delays in investigation or referral; and number who had received inadequate follow up.In all, 11 of the children had received suboptimal medical care, but the management of the other 12 could not have been better. The most common error was failure to investigate possible urinary tract infections, but follow up of confirmed infections was also inadequate. These problems occurred in hospital as well as in general practice.Opportunities for intervention had been missed in nearly half of this sample of children with renal scars.
Abstract 1145: Functional Heterogeneity of Angiopoietin-1, -2 on Endothelial Progenitor Cell Fate, Assessed by Single Cell culture of Cord Blood CD133+cells for Endothelial Lineage Commitment Assay
Authors: Haruchika Masuda, Masamichi Eguchi, Rie Ito, Michiru Kobori, Shunichi Kato, Takayuki Asahara
Journal: Circulation (2007)

Background; Angiopoietin-1, -2 (Ang-1, Ang-2) has been demonstrated to play a pivotal role in angio-vasculogenesis, i.e. Ang-1 for vascular maturation or Ang-2 for vascular sprouting. However, the developmental mechanism of endothelial progenitor cell (EPC) fate oriented by angiopoietins for vasculogenesis remains to be elucidated. Here, we report the assessment of primitive EPC fate determined by Ang-1,-2, using in vitro endothelial lineage commitment assay of single cord blood (CB)-CD133+ cells. Methods; Single CB-CD133+cells isolated by MACS were cultured in a suspension manner for 7 days in liquid culture containing TPO, SCF, IL-6, Flt-3 ligand, and VEGF with either of Ang-1 or Ang-2 at 200 ng/ml each. The cultured cells from single CB-CD133+cells were applied to vasculogenic methylcellulose culture for EPC colony forming assay (EPC-CFA). Results; EPC-CFA disclosed the analytic potential on the degree of differentiation and commitment of single CB-CD133+cells by the assessment of two types of EPC colonies with the individual cellular sizes, i.e. primitive CFU-small and/or definitive CFU-large EPCs produced by single CB-CD133+cell. Whole EPC colony producing potential was upregulated by both Ang-1 and Ang-2 (ratio of total CFU-EPC number; 1.49 fold in Ang-1, 1.39 fold in Ang-2 vs control, p &lt; 0.05). Both the commitment and differentiation frequencies of EPC from CB-CD133+ cell were promoted by Ang-1, inversely the latter inhibited by Ang-2 (commitment= frequency of single CB-CD133+cell producing any CFU-EPC; 1.5 fold in Ang-1: differentiation= frequency ratio of single CB-CD133+cell producing definitive CFU-EPC/single CB-CD133+cell producing any CFU-EPC; 2 fold in Ang-1, 0.27 fold in Ang-2 vs control, p &lt; 0.01). On the other hand, the expansion potential of primitive CFU-EPC from single CB-CD133+ cell was augmented by Ang-2, although downregulated by Ang-1 (expansion= number of primitive CFU-EPC/ single CB-CD133+cell producing any CFU-EPC; 0.78 fold in Ang-1, 1.6 fold in Ang-2 vs control, p&lt; 0.05). Conclusion; A novel in vitro colony assay system to survey EPC fate of single CB-CD133+cells precisely provides the evidences of angiopoietin-1 mechanism for differentiation into definitive EPC and angiopoietin-2 for procurance of primitive.
AN ADVANCE IN CYTOTOXIC STUDIES.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Forensic psychiatry
Authors: J. J Sandford
Journal: BMJ (1999)

Imaging techniques for detection of molecular and cellular processes that precede or accompany lung diseases are needed. Matrix metalloproteinases (MMPs) play key roles in the development of pulmonary pathology. The objective of this study was to investigate the feasibility of in vivo MMP-targeted molecular imaging for detection of lung inflammation and remodeling. <b>Methods:</b> Lung-specific IL-13 transgenic (Club cell 10-kDa protein [CC10]-IL-13 Tg) mice and wild-type littermates were used in this study. Lung structure, gene expression, and MMP activity were assessed by histology, real-time reverse transcription polymerase chain reaction, Western blotting, and zymography. MMP activation was imaged by in vivo small-animal SPECT/CT followed by ex vivo planar imaging. Signal specificity was addressed using a control tracer. The correlation between in vivo MMP signal and gene expression was addressed. <b>Results:</b> CC10-IL-13 Tg mice developed considerable pulmonary tissue remodeling and inflammation. CD68, MMP-12, and MMP-13 were significantly higher in CC10-IL-13 Tg lungs. On in vivo small-animal SPECT/CT and ex vivo planar images, the MMP signal was significantly higher in the lungs of CC10-IL-13 Tg mice than wild-type animals. Furthermore, a nonbinding analog tracer showed significantly lower accumulation in CC10-IL-13 Tg lungs relative to the specific tracer. There was a significant correlation between small-animal SPECT/CT–derived MMP signal and CD68 expression in the lungs (<i>r</i> = 0.70, <i>P</i> &lt; 0.01). <b>Conclusion:</b> Small-animal SPECT/CT–based MMP-targeted imaging of the lungs is feasible and reflects pulmonary inflammation. If validated in humans, molecular imaging of inflammation and remodeling can potentially help early diagnosis and monitoring of the effects of therapeutic interventions in pulmonary diseases.
New and Nonofficial Remedies, 1933: Containing Descriptions of the Articles Which Stand Accepted by the Council on Pharmacy and Chemistry of the American Medical Association on January I, 1933.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sodium depletion related to hydrotherapy for burn injury
Authors: R. A. Gotshall
Journal: JAMA (1968)

Severe sodium depletion occurred in association with treatment of burn injury by repeated submersion in water. There was associated azotemia and loss of potassium and extracellular volume. The abnormalities were promptly reversed with replacement therapy. A primary loss of electrolyte through the burned surface into the whirlpoolbath water is postulated.
Head of ME Association is sacked
Journal: BMJ (2003)

relatively small.Also, patients in the virtual outreach group reported significantly shorter time off work than patients in the standard outpatient group.The trial results provide good evidence that virtual outreach consultations are less time consuming and cheaper for patients and are likely to have a positive impact on productivity.Considering total costs, little justification on economic grounds seems to exist for the adoption of virtual outreach.However, all the benefits may not have been recouped within the six month follow up period, and we did not estimate values of improved patient satisfaction.We may therefore have underestimated the beneficial consequences of virtual outreach.Furthermore, previous subanalysis showed that certain specialties may be more appropriate for virtual outreach than others, 5 and improved selection of patients may also improve the relative cost effectiveness of virtual outreach.We acknowledge the invaluable contribution made by all the participating clinicians and nursing, administrative, and management staff in both the London and Shrewsbury arms of the trial (see bmj.com).Ann Bowling and John Wynn Jones provided valuable input to the design of the study, and we thank Will Coppola for help with extraction of prescription data.The project office in London
FOREIGN CORRESPONDENCE.
Authors: None G. O. M.
Journal: JAMA (1884)

London, August. At the distribution of prizes and certificates to the students of St. Thomas's Hospital, the Archbishop of Canterbury, in acknowledging a vote of thanks, said that he felt great pleasure in the bond of union which existed between Lambeth Palace and St. Thomas's Hospital, and the use which the students were able to make of the Palace fields for their football, cricket and other sports. He was delighted to see how far-reaching the hospital was. It was not simply an institution, but a great nest of institutions. The human organism was one of God's greatest works, and the study of forces and influences must be to them, if they saw below the surface, a great revelation of the name of God. He had read the other day what the character of a good physician and a good surgeon ought to be, and the qualities which he should possess
P05.47 Long-lasting response in spinal metastases from ALK rearranged Non-Small-Cell Lung Cancer treated with different ALK inhibitors
Authors: A Pellerino, R Rudà, F Franchino, G Marchese, F Bruno, F Mo, R Soffietti
Journal: Neuro-Oncology (2018)

About 35–50 % of ALK-rearranged NSCLC patients develop brain metastases (BM), while leptomeningeal metastases (LM) occur in 5% of patients, and spinal intramedullary metastases in < 1%. Few data are available regarding the efficacy of ALK inhibitors in neoplastic spinal disease from NSCLC. In March 2014 a 55 year-old woman developed multiple BM after 2 years from the diagnosis of an ALK-rearranged NSCLC who was receiving crizotinib, a first-generation ALK inhibitor. Crizotinib was continued associated with WBRT with a near-CR (RANO criteria) lasting 12 months. One year later a spinal MRI displayed multiple intramedullary enhancing lesions and diffuse leptomeningeal spread along the cauda equina, with CSF positivity for neoplastic cells. Ceritinib, a second-generation ALK inhibitor, was started and a CR both on MRI and CSF was obtained lasting 18 months. In December 2017 the patient developed a bladder dysfunction and paralytic ileus due to multiple intramedullary spinal and leptomeningeal recurrences. Considering the higher BBB penetration of lorlatinib, a third-generation ALK inhibitor, the patient started the drug and achieved a significant improvement of the urinary incontinence and intestinal transit after 3 months Conversely, no change of the extent of spinal disease was observed on MRI. At this time, the patient is continuing treatment with lorlatinib and she is free of recurrence since 5 months. The development of CNS disease in ALK-rearranged NSCLC has been suggested to be a natural evolution of the disease and/or is correlated to low CNS penetration of the molecular drugs that control the systemic disease. The PROFILE trials (1005 and 1007) have shown longer OS in patients with BM who received crizotinib beyond progression, but data are lacking on the activity of second- and third-generation ALK inhibitors. This is the first report of a prolonged clinical and radiological response using sequentially different ALK inhibitors in a patient with concurrent LM and spinal intramedullary metastases from an ALK-rearranged NSCLC.
Near-fatal hyperkalemia due to ingestion of salt substitute by an infant
Authors: R. J. Kallen
Journal: JAMA (1976)

PREPARATIONS of salt substitute, containing high concentrations of potassium chloride, are readily available and are intended for persons on a table salt (sodium chloride)-restricted diet. We report the occurrence of near-fatal hyperkalemia in an 8-month-old infant without renal disease, who was inadvertently given a large dose of a commercially available salt substitute. <h3>Report of a Case</h3> An 8-month-old infant was brought to the emergency room of Wyler Children's Hospital (University of Chicago Hospitals and Clinics) by his mother on June 15, 1975. The infant had become "stiff" with "rolling back" of the eyes on two occasions about one hour prior to arrival at the hospital. He was unresponsive for two to three minutes each time. A few days earlier, a mild upper respiratory tract infection had developed, and on the day of admission, the patient had emesis on two or three occasions, diarrhea eight or nine times, and became anorectic. He
Aspirin Stopped, beta-Carotene Continued
Journal: JNCI Journal of the National Cancer Institute (1988)

Aspirin Stopped, β-Carotene Continued Get access JNCI: Journal of the National Cancer Institute, Volume 80, Issue 2, 16 March 1988, Page 80, https://doi.org/10.1093/jnci/80.2.80-b Published: 16 March 1988
Zolendronic acid in patients with adenocarcinoma of the prostate M1
Authors: F. E. Calais Da Silva, F. M. Calais Da Silva
Journal: Journal of Clinical Oncology (2005)

4777 Background: There is presently clinic evidence that confirms the value of the bifosphonates in the metastatic bone disease. Studies have demonstrated that the bifosphonates may reduce the bone morbidity, pain, and increase the quality of life in patients with multiple mieloma and bone metastases in breast cancer. In the metastatic prostate cancer several oral and i.v. bifosphonates have demonstrated a symptomatic improvement. Zolendronic Acid is a bifosphonate that has demonstrated to diminish the skeletal related events (SRE) in metastatic prostate cancer. Methods: We have initiated a study with two types of patients, patients with bone metastases, with and without pain, with the primary objective of measuring the efficacy of the zolendronic acid in these patients, evaluating time to reduce the score pain or decrease the analgesic score in symptomatic patients and SRE in those non symptomatic, evaluating time to bone pain and SRE. We started a zolendronic acid 4 mg i.v. monthly. Results: We evaluated 87 patients, 16 non evaluable and 71 evaluable with at least 3 administrations. From these 70 patients, 11 had no pain with a medium follow-up of 9,7 months (3 -22 months) in which 6 (54%) maintain no pain (3 -18 months) and 5 (45%) started pain in average at 6 months (1–11months), no SRE were seen. The other 60 patients had pain at initiation, 24 (40%) with no response and 36 (60%) with response and pain palliation, with an average follow-up of 9,2 months (3 -22 months) with an average time to response of 3.2 (1–8 months) with an average response duration of 4 months (1–11 months), we had only two patients with the need samarium i.v., no other SRE. Conclusions: Zolendronic acid is an i.v. bifosphonate effective in the palliation of pain in patients with bone metastases, with decrease of pain and analgesic score with a fast response in average of 3,2 months and with a therapeutic efficacy maintained in average for 4 months. Also in high-risk patients, with bone M1, but without pain, it was verified that 54% at the end of 9,2 months, in average, maintained no pain and in 45% only at 6 months started with pain. No significant financial relationships to disclose.