tbuckley/cabot-search huggingface dataset:
A Good Beginning.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mitotane
Authors: Jacobo Wortsman
Journal: JAMA (1977)

CUSHING'S syndrome is usually treated surgically when it is associated with pituitary-dependent adrenocortical hyperplasia or an adrenal adenoma. However, the patient's general condition may exclude a surgical approach, and in these cases as well as in certain instances of Cushing's syndrome due to metastatic adrenal carcinoma of ectopic adrenocorticotropic hormone (ACTH) production, medical treatment has a place. The drugs available include mitotane, aminoglutethimide, and metyrapone; more recently, successful treatment of adrenocortical hyperplasia with cyproheptadine hydrochloride has been reported. Mitotane and aminoglutethimide have been the most commonly used, but both have a high incidence of adverse reactions.<sup>1</sup>Only mitotane leads to permanent destruction of the adrenal cortex. Spironolactone is commonly used in the management of the hypokalemia of Cushing's syndrome, but in the case we are presenting, it is suggested that this drug blocks the action of mitotane. <h3>Report of a Case</h3> A 65-year-old woman with features of florid Cushing's
Corpus Luteum Hemorrhage
Authors: Marian Waxman
Journal: JAMA (1978)

Intra-abdominal bleeding from the corpus luteum developed in three women receiving anticoagulant treatment. In one of these patients, no other hemorrhagic manifestations were present. Bleeding from corpus luteum should be considered in differential diagnosis of low abdominal pain in women of reproductive age receiving anticoagulant therapy. The ovary has not been widely recognized as a site of hemorrhage complicating anticoagulant therapy, although abnormal bleeding in this location may be more common than previously thought. Thorough clinical studies are needed to establish the precipitating factors and true incidence of this complication. (<i>JAMA</i>239:2270-2271, 1978)
ADDRESS.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surfing injuries At waikiki
Authors: R. H. Allen
Journal: JAMA (1977)

A 56-month survey of 36 hospitalized patients injured while surfing off Oahu, Hawaii, indicated that 34% of the injuries involved the head and spine. Bodysurfing involves a considerable risk of craniospinal injury if the head is driven into the sand. The most frequent injury in surfboarding is being hit by a loose board. Risk of injury in surfboarding is approximately one per 17,500 surfing days—an incidence far below most sports. (<i>JAMA</i>237:668-670, 1977)
Prospective evidence of a circadian rhythm for out-of-hospital cardiac arrests
Authors: R. L. Levine
Journal: JAMA (1992)

<h3>Objectives.</h3> —Published studies have indicated a circadian rhythm in the occurrence of sudden cardiac death. However, these studies have involved either retrospective analyses of death certificates or analyses of data collected during studies of pharmacologic agents in selected populations. <h3>Purpose.</h3> —To determine whether a circadian pattern could be clearly demonstrated in a prospective study of out-of-hospital sudden cardiac death in a large, unselected population. <h3>Design.</h3> —All adult cases of sudden death of presumed primary cardiac cause from a large urban population were prospectively evaluated over a 12-month period. The incidence of sudden cardiac death was analyzed using harmonic regression of the data tabulated by hour of the day. <h3>Results.</h3> —During the year of study, 1019 consecutive primary cardiac arrests were analyzed. A significant circadian pattern was found (P&lt;.0001) with the frequency of cardiac arrests increasing dramatically from 6 AM until noon. <h3>Conclusions.</h3> —This prospective study of out-of-hospital cardiac arrest confirms the existence of a circadian rhythm. These data have important implications for future investigations concerning the pathophysiology of sudden cardiac deaths. (<i>JAMA</i>. 1992;267:2935-2937)
Long Survival in Hodgkin's Disease.
Authors: Mortimer J. Lacher
Journal: Annals of Internal Medicine (1968)

s1 May 1968Long Survival in Hodgkin's Disease.Mortimer J. Lacher, M.D., F.A.C.P.Mortimer J. Lacher, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1192_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf 402 patients with Hodgkin's disease seen at the Memorial Center between 1949 and 1955, 90 survived more than 10 years. A detailed review of the treatment necessary to achieve more than 10-year survival was undertaken. Clinical data were used to stage the extent of disease at the time of biopsy. Lymphangiograms were not done during this period of time. Overall survival improved considerably compared with 2 previous reviews at the Memorial Center. Five-year survival improved from 17.7% to 38.3%. Ten-year survival improved from 7.7% to 22.4%. Twenty-eight out of 74 (37.8%) stage IA patients survived more than 10 years.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Mortimer J. Lacher, M.D., F.A.C.P.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1192-1192KeywordsBiopsyHodgkin lymphoma ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Choroidal Hemangioma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Connections
Journal: Arthritis & Rheumatology (2017)

During aging, articular chondrocytes undergo changes in homeostatic processes that compromise their function and may contribute to cartilage degradation and osteoarthritis (OA).The regulated in development and DNA damage response 1 (REDD1) protein regulates cell metabolism and coordinates cellular stress responses.Previous studies showed that REDD1 expression is reduced in aged and OA articular cartilage and is a positive regulator of autophagy.Alvarez-Garcia et al examined the role of REDD1 in OA development and identified novel REDD1 functions in articular chondrocytes.Using a mouse model with genetic deletion of REDD1 (REDD1 -/-), they showed that the severity of OA in the destabilized medial meniscus model was increased compared with wild-type (REDD1 +/+ ) mice and that REDD1 deficiency was associated with decreased expression of markers of autophagy and mitochondrial biogenesis in articular cartilage.They further demonstrated that REDD1 is necessary for maintaining normal levels of mitochondrial biogenesis.Maintaining normal levels of REDD1 in articular cartilage during aging may be a promising novel therapeutic strategy for preventing OA.
<i>QuickStats</i>: Age-Adjusted Prevalence*<sup>,</sup>† of Hypertension Treatment§ Among Adults Aged ≥18 Years with Hypertension,¶ by Sex and Race/Ethnicity — National Health and Nutrition Examination Survey, United States, 2011–2014
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

During 2011-2014, 74.6% of adults aged ≥18 years with hypertension reported taking antihypertensive medication. Overall, a smaller percentage of non-Hispanic Asian adults (63.8%) with hypertension reported taking antihypertensive medication compared with non-Hispanic white (75.8%), non-Hispanic black (77.3%), and Hispanic (70.7%) adults with hypertension. This pattern was found for both men and women with one exception: the difference between non-Hispanic Asian men and Hispanic men was not significant. A larger percentage of non-Hispanic white, non-Hispanic black, and Hispanic women reported taking antihypertensive medication than did their male counterparts.
Surreptitious habitual vomiting simulating Bartter's syndrome
Authors: E. Ramos
Journal: JAMA (1980)

A patient with hypokalemic alkalosis, normotensive hyperreninism, hyperaldosteronism, increased levels of urinary and plasma prostaglandin E, and vascular hyporesponsivity to angiotensin II was thought to have Bartter's syndrome. Results of a kidney biopsy showed hyperplasia of the juxtaglomerular apparatus but no renomedullary cell hyperplasia. A 24-hour urine collection showed a low chloride level and no increase in the fractional chloride clearance, thus excluding Bartter's syndrome. Subsequent disclosure of surreptitious, habitual vomiting explained the hypokalemia. (<i>JAMA</i>243:1070-1072, 1980)
Granulomatous Prostatitis
Authors: Panayotis P. Kelalis
Journal: JAMA (1965)

In 70 cases of granulomatous prostatitis 54 (77%) mimicked carcinoma clinically. Granulomatous prostatitis is a distinct clinical and pathological entity, apparently a reaction to extravasated prostatic secretions into the surrounding tissues secondary to obstruction and infection within the prostate. In about 80% of the patients, there was a triad of (1) high fever followed by (2) symptoms of nonspecific prostatitis and (3) suggestion of a malignant prostate on rectal palpation. These features should suggest a presumptive diagnosis of granulomatous prostatitis, although histological confirmation is desirable. The disease occurs at a slightly earlier age than prostatic carcinoma. Empirical nonsurgical treatment will suffice in most cases if sufficient time is allowed for the inflammatory reaction to resolve. This seldom requires more than three months.
Physical Diagnosis in Obstetrics.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doctors’ Confusion over Ratios and Percentages in Drug Solutions: The Case for Standard Labelling
Authors: Daniel Wren Wheeler, Dionysios Dennis Remoundos, Kim David Whittlestone, Michael Ian Palmer, Sarah Jane Wheeler, Timothy Richard Ringrose, David Krishna Menon
Journal: Journal of the Royal Society of Medicine (2004)

The different ways of expressing concentrations of drugs in solution, as ratios or percentages or mass per unit volume, are a potential cause of confusion that may contribute to dose errors. To assess doctors' understanding of what they signify, all active subscribers to doctors.net.uk, an online community exclusively for UK doctors, were invited to complete a brief web-based multiple-choice questionnaire that explored their familiarity with solutions of adrenaline (expressed as a ratio), lidocaine (expressed as a percentage) and atropine (expressed in mg per mL), and their ability to calculate the correct volume to administer in clinical scenarios relevant to all specialties. 2974 (24.6%) replied. The mean score achieved was 4.80 out of 6 (SD 1.38). Only 85.2% and 65.8% correctly identified the mass of drug in the adrenaline and lidocaine solutions, respectively, whilst 93.1% identified the correct concentration of atropine. More would have administered the correct volume of adrenaline and lidocaine in clinical scenarios (89.4% and 81.0%, respectively) but only 65.5% identified the correct volume of atropine. The labelling of drug solutions as ratios or percentages is antiquated and confusing. Labelling should be standardized to mass per unit volume.
PROPOSITI, PHYSICIANS, AND PAPERS
Authors: E. J. H.
Journal: Annals of Internal Medicine (1961)

Editorials1 March 1961PROPOSITI, PHYSICIANS, AND PAPERSE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-3-583 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElsewhere in this number of the ANNALS is a review of a book, weighty in mass and content, The Metabolic Basis of Inherited Disease.1 The conceptual view this new work exemplifies was first set forth in 1909 by Garrod in his little book, Inborn Errors of Metabolism.2 His work, with great implications for the future, received so little notice at the time that Garrison3 gave several pages in his History to Galton and Pearson, then eminent in human genetics, but he did not even mention Garrod's name.The present vigor of medical genetics owes most to the brilliant use of...1 StanburyWyngaardenFredrickson JBJBDS: The metabolic basis of inherited disease. The Blakiston Div., McGraw-Hill Book Co., Inc., 1960. Google Scholar2 Garrod AE: Inborn errors of metabolism. Oxford University Press, London, 1909. Google Scholar3 Garrison FH: An introduction to the history of medicine. W. B. Saunders Co., Philadelphia, 1914. Google Scholar4 Pickles WN: Epidemiology in country practice. New Engl. J. Med. 239: 419-427, Sept. 16, 1948. CrossrefMedlineGoogle Scholar5 WintersGrahamWilliamsMcFallsBurnett RWJBTFVWCH: A genetic study of familial hypophosphatemia and vitamin-D resistant rickets, with a review of the literature. Medicine 37: 97-142, May, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRENAL TUBULAR ACIDOSISJ. R. E., E. J. H. 1 March 1961Volume 54, Issue 3Page: 583-586KeywordsForecastingHuman geneticsMedical genetics ePublished: 1 December 2008 Issue Published: 1 March 1961 PDF downloadLoading ...
Perisinusoidal cell activation, neoangiogenesis, and sinusoidal ?capillarization? in macroregenerative nodules: Evidence for neoplastic progression Depts. of Pathology, *New York University and Mount Sinai Medical Centers, NY NY
Journal: Hepatology (1995)

The incidence of cardiovascular disease is lower in premenopausal women compared with men; following menopause, the risk of mortality from cardiovascular disease increases in females. Postischemic dilatation of the brachial artery has been used previously as an index of endothelium-mediated vasodilation. Using this index, we examined a group of premenopausal and postmenopausal women, some of whom were on estrogen replacement therapy (ERT). All subjects were normotensive (blood pressure [BP] < 140/90mm Hg) and normoglycemic (blood glucose, < 100mg/dL). Fourteen healthy women (mean age, 27 ± 0.8 years; mean total cholesterol, 174 ± 6.7 mg/dL) and fourteen healthy men (mean age, 26 ± 1.4 years; mean total cholesterol, 181 ± 7.2 mg/dL) were investigated. Nineteen postmenopausal women were also examined; 11 were on ERT (mean age, 55 ± 2.1 years; mean total cholesterol, 213 ± 6.6 mg/dL) and eight were not on ERT (mean age, 60 ± 3.6 years; mean total cholesterol, 222 ± 14.4 mg/dL). Ischemia was induced by inflating a cuff over the forearm to a pressure of 40 mm Hg above systolic for 5 minutes. Doppler ultrasonography (Acuson [Mountain View, CA] 128XP/10c ultrasonograph with a 7.5-MHz linear array transducer) was used to measure the brachial artery diameter before inflation and 15 seconds and 45 to 60 seconds following cuff deflation. Flow-mediated dilatation (FMD%) and hyperemia were defined as the percentage increase over basal diameter and basal flow, respectively. Postischemic median dilatation in men was 4.20% (interquartile range, 2.13% to 5.56%) and 11.48% (interquartile range, 8.70% to 14.29%) in age-matched premenopausal women (P < .01). For women on ERT, the postischemic median dilatation was 8.11% (interquartile range, 6.01% to 11.60%), as compared with 2.82% (interquartile range, 1.32% to 3.28%) for women without ERT (P < .01). Premenopausal women showed significantly greater dilatation after ischemia than postmenopausal women without ERT (P < .0001). Hyperemia was similar in all groups. These findings show that postischemic vasodilation of the brachial artery is greater in premenopausal women versus age-matched men; it is decreased in postmenopausal women, and ERT restores it toward normal. The pathophysiology underlying the diminution in postischemic dilatation may be relevant to atherogenesis and coronary artery disease (CAD).
CORTICOSTEROIDS AND CATARACTS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluating Disabilities
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Announcement:</i> Release of National Association of State Public Health Veterinarians’ 2016 Compendium of Animal Rabies Prevention and Control
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

The 2016 Compendium of Animal Rabies Prevention and Control was released in the March 1, 2016 issue of the Journal of the American Veterinary Medical Association (1). The Compendium's national recommendations for the prevention and control of animal rabies are intended to serve as a basis for an effective rabies control program in the United States. These recommendations facilitate standardization of control procedures across jurisdictions and are reviewed annually and updated as necessary. This announcement of the recommendations facilitates their adoption by increasing awareness among public health agencies and practitioners and makes more readily available a link to statutes and regulations in certain jurisdictions that refer directly to the Compendium language published in MMWR.