tbuckley/cabot-search huggingface dataset:
Assessing Cardiovascular Risk Factors in National Football League Players—Reply
Authors: Andrew M. Tucker
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
YELLOW JACK ON AMERICAN SOIL.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
US launches plan to tackle childhood obesity
Authors: D. Josefson
Journal: BMJ (2000)

In an effort to develop selective radioligands for in vivo imaging of neuronal nicotinic acetylcholine receptors (nAChRs), we synthesized 5-iodo-3-(2(<i>S</i>)-azetidinylmethoxy)pyridine (5-iodo-A-85380) and labeled it with <sup>125</sup>I and<sup>123</sup>I. Here we present the results of experiments characterizing this radioiodinated ligand in vitro. The affinity of 5-[<sup>125</sup>I]iodo-A-85380 for α4β2 nAChRs in rat and human brain is defined by <i>K</i><sub>d</sub> values of 10 and 12 pM, respectively, similar to that of epibatidine (8 pM). In contrast to epibatidine, however, 5-iodo-A-85380 is more selective in binding to the α4β2 subtype than to other nAChR subtypes. In rat adrenal glands, 5-iodo-A-85380 binds to nAChRs containing α3 and β4 subunits with 1/1000th the affinity of epibatidine, and exhibits 1/60th and 1/190th the affinity of epibatidine at α7 and muscle-type nAChRs, respectively. Moreover, unlike epibatidine and cytisine, 5-[<sup>125</sup>I]iodo-A-85380 shows no binding in any brain regions in mice homozygous for a mutation in the β2 subunit of nAChRs. Binding of 5-[<sup>125</sup>I]iodo-A-85380 in rat brain is reversible, and is characterized by high specificity and a slow rate of dissociation of the receptor–ligand complex (<i>t</i><sub>1/2</sub> for dissociation ∼2 h). These properties, along with other features observed previously in in vivo experiments (low toxicity, rapid penetration of the blood-brain barrier, and a high ratio of specific to nonspecific binding), suggest that this compound, labeled with <sup>125</sup>I or <sup>123</sup>I, is superior to other radioligands available for in vitro and in vivo studies of α4β2 nAChRs, respectively.
Crystallin Genes: Lens Specificity of the Murine aA-Crystallin Gene
Authors: Ana B. Chepelinsky, Jaspal S. Khillan, Kathleen A. Mahon, Paul A. Overbeek, Heiner Westphal, Joram Piatigorsky
Journal: Environmental Health Perspectives (1987)

The abundant soluble proteins of the eye lens, the crystallins, are encoded by several gene families which are developmentally regulated in the embryonic lens.We have studied the expression of the murine aA-crystallin gene.Transfection experiments using the pSVO-CAT vector and explanted lens epithelia from embryonic chickens demonstrated proximal (-88 to -60) and distal (-111 to -85) regulatory sequences which interact when the aA-crystallin promoter is activated in the lens cells.Transgenic mouse experiments showed that the sequence between positions -366 to + 46 of the aA-crystallin promoter can drive foreign genes selectively in the lens.A fusion gene consisting of this aA-crystallin promoter sequence and the T-antigen gene of SV40 produced a lens tumor in transgenic mice.Thus, crystallin promoters provide a useful model for tissue-specific gene expression and permit targeting the expression of foreign genes to a highly differentiated tissue during development.
Systemic Mastocytosis
Authors: K. Frank Austen
Journal: New England Journal of Medicine (1992)

THE hyperplasia of mast cells that defines systemic mastocytosis in most cases is neither clonal nor neoplastic.1 It can occur at any age and is slightly more common in men than women. Because mast cells originate from pluripotent bone marrow cells that are disseminated as precursors and then undergo proliferation and maturation in specific tissues, the hyperplasia is generally manifested in bone marrow, as well as in peripheral sites such as the skin, gastrointestinal tract, liver, and spleen. A recent consensus classification of systemic mastocytosis2 recognizes four forms: an indolent form, which constitutes the majority of cases and is not . . .
Reply
Authors: S.J. Adams, C.P. Swain, T.N. Mills, S.G. Bown, P.R. Salmon
Journal: British Journal of Dermatology (1988)

Journal Article Reply Get access S.J. Adams, S.J. Adams Department of Medical Physics and Bioengineering University College London 11–20 Capper Street, London WC1A 6JA U.K. Search for other works by this author on: Oxford Academic Google Scholar C.P. Swain, C.P. Swain Department of Medical Physics and Bioengineering University College London 11–20 Capper Street, London WC1A 6JA U.K. Search for other works by this author on: Oxford Academic Google Scholar T.N. Mills, T.N. Mills Department of Medical Physics and Bioengineering University College London 11–20 Capper Street, London WC1A 6JA U.K. Search for other works by this author on: Oxford Academic Google Scholar S.G. Bown, S.G. Bown Department of Medical Physics and Bioengineering University College London 11–20 Capper Street, London WC1A 6JA U.K. Search for other works by this author on: Oxford Academic Google Scholar P.R. Salmon P.R. Salmon Department of Medical Physics and Bioengineering University College London 11–20 Capper Street, London WC1A 6JA U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 119, Issue 1, 1 July 1988, Page 132, https://doi.org/10.1111/j.1365-2133.1988.tb07119.x Published: 01 July 1988
International Medical Annual: A Year-Book of Treatment and Practitioner's Index.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Newer pertussis vaccines on horizon
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An International System of Electro-Therapeutics. For Students, General Practitioners, and Specialists.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIHYDROXYACETONE.
Authors: P. B. MUMFORD
Journal: British Journal of Dermatology (1960)

Journal Article DIHYDROXYACETONE. Get access P. B. MUMFORD P. B. MUMFORD Manchester and Salford Hospital for Skin Diseases, Manchester, 3 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 72, Issue 7, 1 July 1960, Pages 279–280, https://doi.org/10.1111/j.1365-2133.1960.tb13891.x Published: 01 July 1960
Paraffin-Based 6-Gene Model Predicts Outcome of Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP.
Authors: Raquel Malumbres, Nathalie A. Johnson, Laurie H. Sehn, Yaso Natkunam, Rob Tibshirani, Javier Briones, Joseph M. Connors, Ronald Levy, Randy D. Gascoyne, Izidore S. Lossos
Journal: Blood (2007)
Africa Live
Authors: Leslie Lee
Journal: BMJ (2005)

Directed by Mick Czáky To be broadcast throughout Africa DVD release date: September 2005 http://www.africalive-festival.com/ Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> O n a stage with billowing nets and giant “mosquitoes”—dancers dressed in costumes designed by Oumou Sy—Nigeria's Seun Kuti mesmerised a crowd of 50 000 with his “Mosquito Song.” This slightly surreal public health message is one of the highlights from a concert in Dakar on 12-13 March this year that was organised by Senegalese Grammy winner Youssou N'Dour. More than 150 of Africa's top musicians entertained concertgoers—and warned of malaria's dangers. The concert, backed by the Roll Back Malaria Partnership, features performances from former Rwandan refugee … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
TOO FEW PHYSICIANS? HARDLY!
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterial Metabolism.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHARTER OF THE NEW YORK STATE MEDICAL ASSOCIATION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Serum lipid concentrations in obesity
Authors: A Khan, M Maguire
Journal: BMJ (1978)

appear to be of the RII category.Though we have seen several other patients with apparent chloroquine resistance, either they have been too ill to delay alternative treatment or they have had several courses of chloroquine before testing for resistance and have finally responded to the test course.It is now our practice to use chloroquine by mouth in a dose of 10 mg/kg, repeated after six hours, then daily for three days.This is the general dosage by WHO recommended standards.2We believe that chloroquine resistance is appearing in Zambia and that clinicians must watch for this.In such cases we have had success with a combination of doxycycline and quinine or chloroquine.
A randomized comparison of external and internal cardioversion of chronic atrial fibrillation.
Authors: S Levy, F Morady
Journal: Circulation (1993)

Cardioversion of Chronic Atrial FibrillationWe thank Dr. Ewy' for his editorial comment on our study2 and would like to respond to the issues he raised.The first comment refers to the low success rate that we obtained with external shocks compared with the pioneering reports of Lown et al.34 Their initial report3 included only 10 patients who were undergoing mitral valve operation; sinus rhythm was restored in eight of these.The second report4 was a lecture, and the results of cardioversion are difficult to compare with the results of other reports.The duration of atrial fibrillation, number of sessions of cardioversion, and number of shocks per patient were not detailed; the energy delivered was not standardized.Whereas a majority of patients in our study had coronary artery disease, hypertensive heart disease, or dilated cardiomyopathy, valvular heart disease was the cause of atrial fibrillation in 70% of patients in the Lown report.4Note that 35% of the patients in the external cardioversion group and 45% in the internal group in our study had a history of congestive heart failure, and 36% of patients in the external cardioversion group had failed previous electrical cardioversion attempts.2Note also the long duration of atrial fibrillation in many patients in our study, with 43% of patients in the external cardioversion group having had atrial fibrillation for >2 years.Dr. Ewy found our description of the external cardioversion technique not detailed enough.The paddles were standard size (3x5 in.) and were applied to the chest wall manually with firm pressure.The paddles were positioned in an anterolateral fash- ion and not apicoposteriorly as stated in his editorial.The purpose of our study was not to compare the "optimal technique of external cardioversion" (which to our knowledge has not been universally defined) with internal cardioversion but instead to compare a conventional method of external cardioversion with internal cardioversion.We are aware that electrode position, electrode size, and other parameters may influence the results of external cardioversion.5-7Nevertheless, our study demonstrated that internal cardioversion is more effective than and as safe as conventional external cardioversion in patients with chronic atrial fibrillation.Transvenous internal high-energy cardioversion of chronic atrial fibrillation is not an alternative to external cardioversion.It has proved to be safe and effective and serves as an additional tool to convert patients with chronic atrial fibrillation to sinus rhythm if external cardioversion fails.We hope Dr. Ewy will try this technique in his patients with chronic atrial fibrillation who fail to respond to external cardioversion.
润肤剂和局部糖皮质激素治疗成人湿疹
Authors: S. Lundin, C.F. Wahlgren, A. Bergström, E.K. Johansson, E. Dahlén, N. Andersson, I. Kull
Journal: British Journal of Dermatology (2018)

湿疹,也称为异位性湿疹,是一种常见的儿童皮肤病。湿疹患者通常出现皮肤干燥,常伴有瘙痒皮疹。全球大约10‐30%的儿童受此病困扰。在瑞典,20%的儿童在5岁之前患过或持续患有湿疹。这种疾病随着年龄的增长会越来越少见,只有2‐10%的成人受其困扰。针对湿疹,应使用润肤剂(保湿剂)来应对皮肤干燥,并使用可的松药膏来治疗瘙痒皮疹。关于青少年湿疹的知识比较贫乏。本项研究在瑞典开展,旨在找出患有湿疹的青少年如何使用润肤剂和可的松药膏自行治疗:男生和女生在自行治疗方面是否不同,湿疹严重程度是否影响治疗行为以及他们在过去一年使用了多少从药房购买的可的松药膏。作者使用的数据来自16岁青少年,这些青少年回答了关于湿疹及其治疗的问题并参加了临床检查。主要发现表明,几乎所有青少年都使用润肤剂,但是只有半数使用可的松药膏,而男生和女生在如何自行治疗方面并无差异。湿疹症状加重,使用可的松的可能性也不会增加。在中度到非常严重的湿疹患者中,只有四分之一的患者在过去一年使用过从药房购买的强效可的松药膏。因此,作者得出结论,许多患有湿疹的青少年治疗不足或完全没有治疗。
Anaphylaxis from chymopapain
Authors: K. Agre
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Dr I. Leonard Bernstein's<sup>1</sup>recent letter concerning the incidence of anaphylaxis and mortality during chemonucleolysis for herniated lumbar intervertebral disks was based in part on information also published inThe Journal.<sup>2,3</sup>An ongoing, postmarketing surveillance program initiated by Smith Laboratories at the time the Food and Drug Administration approved Chymodiactin, our formulation of chymopapain, has provided important data from an additional 18,323 patients that can now be added to the data from the approximately 1,600 patients who participated in our clinical trials before FDA release. First, none of the 18,323 patients described in the surveillance program as of Aug 29, 1983, has died of an allergic reaction, leading to an overall mortality rate for Chymodiactintreated patients of 0.01%. This is markedly reduced from the 0.15% mortality figure cited by Dr Bernstein and is considerably less than the 0.12% mortality reported for laminectomy (<i>Acta Med Scand</i>1972;142:1-95).
Clinical Geriatrics
Authors: Theodore R. Reiff
Journal: JAMA (1982)

This book is a major and important contribution to the newly developing field of geriatric medicine. The editor, who is also a contributor, is a well-known figure who, himself, has played no small role in promoting the importance of geriatric medicine as a clinical discipline and was a pioneer in developing home-care principles and practice. He has assembled a group of experts, many of whom are also contributors to this developing discipline, to write chapters in their fields of expertise. One of the very worthwhile parts of this book is part 1, "Aging Changes," which contains four chapters dealing with anatomy of aging, organ-function decline with aging, cellular aging, and general aspects of aging. This part provides the biologic basis for many of the clinical chapters appearing in the last five parts, or most of the book. Most of the clinical chapters emphasize mechanisms and are well referenced. The book