tbuckley/cabot-search huggingface dataset:
Methods of Psychology
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Industrial Medicine and Surgery, Miami
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase 2a Open-Label Study to Investigate Safety and Tolerability (including the MTD), Efficacy, Pharmacokinetics, Pharmacodynamics and Immunogenicity of MT-3724 in Combination with Lenalidomide in Subjects with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma
Authors: Christine Burnett, Gary Gordon, Thomas Strack, Tara Lehner, Jack P Higgins, Jason Tache
Journal: Blood (2019)
RARE-25. LONG-TERM OUTCOME OF SKULL BASE CHORDOMAS IN CHILDREN AND ADOLESCENTS
Authors: M. Maher Hulou, Marcio Rassi, Kaith Almefty, Wenya Linda Bi, Svetlana Pravdenkova, Ian Dunn, Timothy Smith, Ossama Al-Mefty
Journal: Neuro-Oncology (2016)

Chordomas are rare tumors, occurring in children at a rate of 1.4 per 10 million population. Current comprehension and a unified management strategy for pediatric chordomas remain lacking. We investigated the clinical and radiological features of clival chordomas in young patients, with an emphasis on surgical outcomes and predictors of survival following our management protocol of radical surgical resection with adjuvant proton/photon radiotherapy. Data from 31 patients, age 22 years or younger, referred to the senior author (OA) from 1993 to 2008 were reviewed. Thirteen patients that had received previous treatment did not require surgical intervention at referral. Eighteen patients that were treated in accordance with our practice were included in the survival analysis. Mean follow-up was 123 months. Age, gender, extent of resection, tumor status at presentation and histopathology were analyzed. Mean age at diagnosis among the cohort (17 girls, 14 boys) was 10.6 years. Abducens nerve palsy was the most frequent presenting symptom. Radiological features mirrored those observed in adults; however, children frequently presented with large tumors associated with the involvement of multiple anatomical compartments. Increased progression-free survival was related with gross total resection (mean 192 mo), compared to subtotal resection (mean 25.6 mo; p = 0.025); typical pathology (mean 174.9 mo), compared to atypical pathology (mean 17.3 mo; p = 0.019), and surgery on primary tumors (mean 195 mo), compared to surgery on recurrent tumors (mean 27.8 mo; p = 0.016). The results of this series, which included a sizeable number of patients, treated in a consistent manner, by one surgeon, with a long-term follow-up period, make significant findings of the value of radical surgical resection associated with adjuvant proton/photon radiotherapy for a longer survival of children and adolescents with skull base chordoma.
Fetal Tolerance to Maternal Antigens Improves the Outcome of Allogeneic Bone Marrow Transplantation by a CD4+CD25+ T Cell-Dependent Mechanism.
Authors: Ken-ichi Matsuoka, Tatsuo Ichinohe, Shoji Asakura, Daigo Hashimoto, Mitsune Tanimoto, Takanori Teshima
Journal: Blood (2005)
Incorrect P Value
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Real World Outcomes of Adult B-Cell Acute Lymphocytic Leukemia Patients Treated with Inotuzumab Ozogamicin
Authors: Talha Badar, Aniko Szabo, Martha Wadleigh, Michaela Liedtke, Shukaib Arslan, Caitlin Siebenaller, Ibrahim Aldoss, Elizabeth Schultz, Mehrdad Hefazi, Mark Litzow, Eric Kuo, Amy Wang, Emily K Curran, Rory M Shallis, Nikolai A. Podoltsev, Suresh Kumar Balasubramanian, Jay Yang, Ryan J. Mattison, Madelyn Burkart, Shira Dinner, Anjali S. Advani, Ehab L. Atallah
Journal: Blood (2019)
Elementary Course in Design and Analysis of Scientific Experiments
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Elementary Course in Design and Analysis of Scientific Experiments Get access JNCI: Journal of the National Cancer Institute, Volume 58, Issue 4, April 1977, Page 1177, https://doi.org/10.1093/jnci/58.4.1177-a Published: 01 April 1977
<i>Erratum</i>: Vol. 69, No. 5
Authors: Faruque Ahmed, Olivia Almendares, Ashwin Belludi, Isaac Benowitz, Chris Braden, Christina Carlson, Howard Chiou, Nakia Clemmons, Dave Daigle, Meghna Desai, Lindsey Duca, Marc Fischer, Isaac Ghinai, Carolyn Greene, Cheri Grigg, Ardath Grills, Katherina Grusich, Benjamin Hallowell, Connor Hoff, Jesica Jacobs, Bradley King, John MacArthur, Claire Mattison, Jason McDonald, Tristan McPherson, Alexander Millman, Shannon Novosad, Mary Pomeroy, Noreen Qualls, Maryan Reynolds, Heather Rhodes, Rajeev Sharma, Robert Simmonds, Rebekah Stewart, Rebecca Sunenshine, Mark Tenforde, Amra Uzicanin, Jennifer Verani, Florence Whitehill, Kathryn Wilson, Jonathan Wortham
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

4, 2020 the Food and Drug Administration issued an Emergency Use Authorization to enable emergency use of CDC's 2019-nCoV Real-Time RT-PCR Diagnostic Panel."On page 142, the first sentence of the first paragraph in the second column should have read "CDC is working closely with FDA and public health partners, including the Association of Public Health Laboratories, to rapidly share these tests domestically and internationally through CDC's International Reagent Resource (https://www.internationalreagentresource.org/)."In addition, names of the members of the 2019-nCoV CDC Response Team were omitted.The names are included below.
Thyrotropin-releasing hormone in the dorsal vagal complex stimulates hepatic blood flow in rats
Authors: M Yoneda
Journal: Hepatology (2003)

Central administration of thyrotropin-releasing hormone (TRH) enhances hepatic blood flow in animal models. TRH nerve fibers and receptors are localized in the dorsal vagal complex (DVC), and retrograde tracing techniques have shown that hepatic vagal nerves arise mainly from the left DVC. However, nothing is known about the central sites of action for TRH to elicit the stimulation of hepatic blood flow. The effect of microinjection of a TRH analogue into the DVC on hepatic blood flow was investigated in urethane-anesthetized rats. After measuring basal flow, a stable TRH analogue (RX-77368) was microinjected into the DVC and hepatic blood flow response was observed for 120 minutes by laser Doppler flowmetry. Either left or right cervical vagotomy or hepatic branch vagotomy was performed 2 hours before the peptide. Microinjection of RX-77368 (0.5-5 ng) into the left DVC dose-dependently increased hepatic blood flow. The stimulation of hepatic blood flow by RX-77368 microinjection into the left DVC was eliminated by left cervical and hepatic branch vagotomy but not by right cervical vagotomy. By contrast, microinjection of RX-77368 into the right DVC did not significantly alter hepatic blood flow. These results suggest that TRH acts in the left DVC to stimulate hepatic blood flow through the left cervical and hepatic vagus, indicating that neuropeptides may act in the specific brain nuclei to regulate hepatic function. (Hepatology 2003;38:1500-1507.)
Abstract 16948: Local Low Endothelial Shear Stress (ESS) Provides Incremental Prediction of Non-culprit MACE in Addition to Plaque Burden, Minimal Lumen Area, and Plaque Morphology: The PROSPECT Study
Authors: Peter H Stone, Akiko Maehara, Ahmet U Coskun, Charles C Maynard, Ioannis Andreou, Gerasimos Siasos, Marina Zaromitidou, Dimitris Fotiadis, Kostas Stefanou, Michail Papafaklis, Lampros Michalis, Alexandra J Lansky, Gary S Mintz, Patrick W Serruys, Charles L Feldman, Gregg W Stone
Journal: Circulation (2015)

Introduction: Low ESS, a pro-inflammatory stimulus, is an important predictor of coronary plaque development/progression. Whether low ESS adds incremental predictive value for future major adverse cardiac events (MACE) in untreated coronary lesions in high-risk patients with an acute coronary syndrome (ACS) is unknown. Methods: In the PROSPECT study, 697 patients with ACS underwent 3-vessel intracoronary imaging. Independent predictors of non-culprit (nc) lesion MACE from untreated coronary lesions in 3 year followup (f/u) were large plaque burden (PB), small minimum lumen area (MLA), and thin cap fibroatheroma (TCFA) morphology. In the present analysis, all nc-lesions leading to a new MACE in f/u (nc-MACE lesions, n=50) and ~4-fold randomly selected control nc-lesions without f/u MACE (nc-non-MACE lesions) were analyzed. Baseline ESS for each lesion was calculated using computational fluid dynamics. A propensity score for low ESS was determined accounting for PB, MLA, TCFA, artery and location in the artery. Local ESS (lowest ESS in 90 o arc around the artery) was then examined for incremental association with MACE. Results: Imaging was sufficient for analysis in 32 nc-MACE lesions. Two nc-MACE lesions were excluded due to unreliable lesion morphology. Non-fibroatheromas were too few for analysis and excluded. Final dataset included 145 lesions: 13 nc-MACE TCFA, 10 nc-MACE thick cap fibroatheroma (ThCFA), and 122 non-nc-MACE lesions (63 TCFA, 59 ThCFA). Cumulative frequency distribution shows lesions responsible for future nc-MACE frequently exhibited low ESS (Figure). In a propensity-adjusted multivariable model, low ESS was strongly associated with nc-MACE in f/u (odds ratio 0.16 [95% CI 0.06-0.40], p&lt;0.0001). Conclusions: After accounting for large PB, small MLA, TCFA, and lesion location, low local ESS adds significant and substantial incremental predictive value to identify high-risk untreated lesions likely to cause MACE during 3 year followup.
Clinical Factors and Laboratory Correlates of Egg Allergy Resolution in a Cohort of Infants with Egg Allergy (COFAR)
Authors: Scott H. Sicherer, Robert A. Wood, Brian P. Vickery, David Mark Fleischer, Stacie M. Jones, Alice Henning, A. Wesley Burks, Andrew H. Liu, Alexander V. Grishin, Lloyd F. Mayer, Donald Stablein, Hugh A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2013)
Poststreptococcal Arthritis
Authors: WAYNE W. KILLION
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 April 1979Poststreptococcal ArthritisWAYNE W. KILLION JR., M.D., JOE G. HARDIN JR., M.D.WAYNE W. KILLION JR., M.D.Search for more papers by this author, JOE G. HARDIN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-4-718 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have read with interest the recent report by McDanald and Weisman (1) in the December 1978 issue, and there are several problems in their article we believe need addressing. One of the most useful diagnostic features of rheumatic fever has been the migratory pattern of arthritis, which is uncommon in other arthritides. Previous reports (2, 3) of much larger series of adults with this disease have emphasized this aspect of the disease, and, although not carefully documenting this, made no mention of the additive polyarthritis described in McDanald's and Weisman's patients. Tenosynovitis, which occurred in the...References1. MCDANALDWEISMAN EM: Artucular manifestations of rheumatic fever in adults. Ann Intern Med 89:917-920, 1978 LinkGoogle Scholar2. ADATTOPOSKEPOUGETPILEMONTGOMERY IRJCM: Rheumatic fever in the adult. JAMA 194:1043-1048, 1965 CrossrefMedlineGoogle Scholar3. BARNERTTERRYPERSELLIN AER: Acute rheumatic fever in adults. JAMA 232:925-928, 1975 CrossrefMedlineGoogle Scholar4. PERSELLIN R: Acute rheumatic fever: changing manifestations (editorial). Ann Intern Med 89:1002-1003, 1978. LinkGoogle Scholar5. GORDIS L: Effectiveness of comprehensive-care programs in preventing rheumatic fever. N Engl J Med 289:331-335, 1973. CrossrefMedlineGoogle Scholar1. STOLLERMAN G: Laboratory findings and diagnosis, in Rheumatic Fever and Streptococcal Infection. New York, Grune and Stratton, 1975, p. 183 Google Scholar2. STOLLERMAN G: Epidemiology of rheumatic fever. See Reference 1, p. 70 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WAYNE W. KILLIONJR., M.D.; JOE G. HARDINJR., M.D.Affiliations: University of South Alabama Medical Center Mobile, AL 36617 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1979Volume 90, Issue 4Page: 718-719KeywordsArthritisRheumatic fever ePublished: 1 December 2008 Issue Published: 1 April 1979 PDF downloadLoading ...
Plasma cortisol assay. Interference by spironolactone
Authors: A. O. Lurie
Journal: JAMA (1970)

A misleading, gross elevation of plasma cortisol levels was found in patients treated with spironolactone when a popular fluorometric technique for cortisol assay was employed. It was demonstrated that spironolactone interferes with the assay because its fluorescence emission spectrum is identical to that of cortisol. The assay of urinary 17-ketosteroids and 17-ketogenic steroids appears to be unaffected by the presence of spironolactone and can be used for the investigation of adrenal disease in patients taking the drug.
Does capitation affect the health of the chronically mentally ill? Results from a randomized trial
Authors: N. Lurie
Journal: JAMA (1992)

<h3>Objective.</h3> —To determine the effect on health outcomes of enrollment of chronically mentally ill Medicaid recipients in prepaid plans vs traditional fee-for-service Medicaid. <h3>Design.</h3> —A randomized controlled trial. Clients who were randomly assigned to prepaid care were then permitted to choose among four capitated health plans. Clients returned to fee-for-service care at the end of the demonstration. <h3>Setting.</h3> —The Medicaid Demonstration Project in Hennepin County, Minnesota, the urban center of which is Minneapolis. <h3>Patients.</h3> —Seven hundred thirty-nine Medicaid clients who were classified as having chronic mental illness on the basis of Medicaid claims. Clients were interviewed at baseline (time 1) and at two follow-up points. Data were available for 96% of participants at the end of the intervention (time 2). Average duration of follow-up was 11 months. A subset of 370 clients with schizophrenia was followed up 11 months after the return of the prepaid group to fee-for-service care (time 3). <h3>Main Outcome Measures.</h3> —General health status, physical functioning, social functioning, and psychiatric symptoms, assessed using the Schedule of Affective Disorders and Schizophrenia—Change version, the Global Assessment Scale, and indicators of community function. <h3>Results.</h3> —No significant differences between prepaid and fee-for-service groups in general health or psychiatric symptoms from baseline to time 2. After regression adjustment, 12% fewer clients in the prepaid group reported being victimized (<i>P</i>&lt;.01). At the end of time 3, the regression-adjusted Global Assessment Scale scores had worsened by 7.6 points more in the prepaid group in comparison with the fee-for-service group (<i>P</i>&lt;.02). <h3>Conclusion.</h3> —There was no consistent evidence of harmful effects of enrolling chronically mentally ill Medicaid clients in prepaid care, at least in the short run. The generalizability of these findings may be limited to plans that control utilization by methods similar to those used in this study setting. Longer-term outcome studies should be undertaken to clarify the strength of the findings. (<i>JAMA</i>. 1992;267:3300-3304)
Anorexia nervosa
Authors: Jane Morris, Sara Twaddle
Journal: BMJ (2007)

Anorexia nervosa has the highest mortality of any psychiatric disorder. 1It has a prevalence of about 0.3% in young women.It is more than twice as common in teenage girls, with an average age of onset of 15 years; 80-90% of patients with anorexia are female.Anorexia is the most common cause of weight loss in young women and of admission to child and adolescent hospital services.Most primary care practitioners encounter few cases of severe anorexia nervosa, but these cause immense distress and frustration in carers and professionals.We describe the clinical features of anorexia nervosa and review the current evidence on treatment and management.How good is the evidence for managing anorexia nervosa?Ironically, this most lethal of psychiatric disorders is the Cinderella of research.It is hard to engage patients with anorexia for treatment, let alone research.Furthermore, the complexity of coordinated approaches used in most specialist centres may overwhelm conventional research methods.High quality evidence on the effects of starvation on the body is available to guide physical aspects of care. 2 Genetic studies, including twin and family studies, 3 and more recently gene analysis, have shed some light on causes, but few randomised controlled trials of treatment exist.In contrast, many randomised controlled trials are found on the management of normal weight bulimia nervosa. 4Unfortunately, these interventions have a poor response in anorexia nervosa.This review is based on searches in PubMed, Medline, and PsycLIT for treatment of anorexia nervosa and related eating disorders, and the National Institute for Health and Clinical Excellence (NICE) clinical guideline. 5We found no category A evidence (at least one randomised controlled trial as part of a high quality and consistent body of literature (evidence level 1)), and only family interventions met category B criteria (well conducted clinical studies but no randomised controlled trials (evidence levels 2 and 3) or extrapolated from level I evidence).NICE uses category C recommendations (expert committee reports or clinical experience of respected authorities (evidence level 4) or extrapolation from level 2 or 3) to provide guidance where high quality formal evidence is absent.Two Cochrane reviews cover antidepressant treatment for anorexia nervosa 6 and individual
Joint pain and joint hypermobility in inflammatory bowel disease
Authors: A. Fikree, Q. Aziz, R. Aktar, F. Hartley, C. Denning, R. Grahame, D. Rampton
Journal: Gut (2011)

<h3>Abstract</h3> Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Here we integrated transcriptomic and epigenomic analyses of postmortem human brains of FTD patients with mutations in MAPT, GRN and C9orf72 and detected common and distinct dysregulated cellular pathways between patient groups. Our results highlight that excitatory neurons are the most vulnerable neuronal cell type and that vascular aberrations are a common hallmark in FTD. Via integration of multi-omics data, we detected several transcription factors and pathways which regulate the strong neuroinflammation observed in FTD-GRN. Small RNA-seq data and verification experiments in cellular models identified up-regulated miRNAs that inhibit cellular trafficking pathways in FTD and lead to microglial activation. These findings shed light on novel mechanistic and pathophysiological hallmarks of FTD. The data represent the 1<sup>st</sup> phase of a multi-omics, multi-model data resource for FTD research which allows in-depth molecular research into disease mechanisms that will further mechanistic FTD research.