tbuckley/cabot-search huggingface dataset:
Interface
Authors: Christopher M. Callahan
Journal: Annals of Internal Medicine (1992)

On Being A Doctor15 June 1992InterfaceChristopher M. Callahan, MDChristopher M. Callahan, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-12-1025 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is an interesting window in the nursing home downtown. It is two windows really, one encircling the other. The larger, an entire wall of clear glass blocks, extends from floor to ceiling. In the center of this wall of glass is a window that no longer functions as a window because the upper pane has been painted green and the lower pane has been replaced with an air conditioner. The disabled window and the wall of glass are the focal point of an otherwise drab smoking parlor whose permanent furnishings include mismatched folding chairs, a token antique dresser, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1992Volume 116, Issue 12_Part_1Page: 1025-1026KeywordsNursing homes Issue Published: 15 June 1992 Copyright© 1992 American College of PhysiciansPDF DownloadLoading ...
LAWAND MEDICINE
Authors: Nick G. Onychuk
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microangiopathic Hemolytic Anemia and the Development of the Malignant Phase of Hypertension
Authors: HARALAMBOS GAVRAS, WILLIAM C. B. BROWN, JEHOIADA J. BROWN, ANTHONY F. LEVER, ADAM L. LINTON, ROBERT F. MACADAM, GEORGE P. MCNICOL, J. IAN S. ROBERTSON, CHARLES WARDROP
Journal: Circulation Research (1971)

Evidence of microangiopathic hemolytic anemia (MHA) was found in 14 of 22 patients with malignant phase hypertension, and in one of these, a patient with proliferative glomerulonephritis, MHA and malignant hypertension developed together during a three-month period of observation. Among 61 rats subjected to unilateral nephrectomy, injected with DOCA, and given 1% saline to drink, 42 developed evidence of MHA. Eighty-four per cent of these also had fibrinoid necrosis and/or plasmatic vasculosis in the remaining kidney at autopsy. Blood pressure rose to 150 mm Hg or more in 72% of these DOCA-injected animals. In 29 control rats subjected to unilateral nephrectomy only, blood pressure rose to 150 mm Hg or more in 21%, MHA developed in 14%, and fibrinoid lesions were found in none. The significance of these observations is discussed in relation to the possibility that MHA is either a consequence of malignant hypertension or a contributory factor in its pathogenesis.
Extracellular ATP, intracellular calcium and canalicular contraction in rat hepatocyte doublets
Authors: T Kitamura
Journal: Hepatology (1991)

Bile-canaliculus contraction in rat hepatocyte doublets is postulated to involve activation of an actinmyosin system. We examined this hypothesis by determining the relationship between canalicular contraction and cystolic free Ca2+ ([Ca2+]i) concentration after extracellular addition of ATP or microdialysis of myosin light chain kinase or its Ca2+-independent fragment, which retains catalytic activity. After incubation of doublets with 200 μmol/L ATP in the absence of extracellular Ca2+, [Ca2+]i peaked at 40 sec and 71% of canaliculi contracted within 4 min. Decreasing effects were observed with equimolar ADP, AMP and nonhydrolyzable ATP, but no effect was observed with adenosine. The effect of extracellular ATP on [Ca2+]i and canalicular contraction was dose dependent. Addition of extracellular Ca2+ and ATP resulted in a plateau level of [Ca2+]i. Cytochalasin D, which depolymerizes actin filaments, inhibited ATP-induced canalicular contraction, but not the increase in [Ca2+ Microdialysis of myosin light chain kinase and its Ca2+-independent fragment (but not the heatdenatured fragment, albumin, trypsin plus soybean inhibitor or buffer) into one hepatocyte of a doublet resulted in canalicular contraction in 86% of doublets. Injection of myosin light chain kinase or its Ca2+-independent fragment did not increase [Ca2+]i within 5 min. These results indicate that (a) the basolateral plasma membrane of hepatocytes has a P2Y-class purinoceptor, (b) increased [Ca2+]i after incubation with ATP is initially due to mobilization from internal sites and (c) canalicular contraction is directly related to [Ca2+]i and activation of an actin-myosin system. The physiological role of extracellular ATP in canalicular contraction is uncertain. (HEPATOLOGY 1991;14:640–647.)
Identification of casein as the major allergenic and antigenic protein of cow's milk
Authors: G. H. Docena, R. Fernandez, F. G. Chirdo, C. A. Fossati
Journal: Allergy (1996)

Docena GH, Fernandez R, Chirdo FG, Fossati CA. Identification of casein as the major allergenic and antigenic protein of cow's milk. The objective of this study was to analyze both the allergenicity and immunogenicity of cow's milk proteins. To this end, 80 milk-atopic patients were selected on the basis of the presence of cow's milk-specific IgE antibodies in serum and compatible clinical history. Fifteen patients allergic to other allergens and 10 nonatopic subjects were studied as controls. The specificity of serum IgG and IgE antibodies was determined by immunoblotting, employing both cow's milk and milk components, i.e., α- and β-casein, β-lactoglobulin, and α-lactalbumin separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The experiments showed that casein-specific IgE antibodies were present in all (80/80) sera examined; 10/80 showed reactivity to β-lactoglobulin, and 5/80 showed reactivity to α-lactalbumin. None of the 25 negative control sera analyzed showed the presence of specific IgE antibodies against milk proteins. These results were similar to those corresponding to the detection, by the radioallergosorbent test, of IgE antibodies against the milk components coupled to paper disks. All sera from milk-atopic patients also showed IgE reactivity against a high-molecular-mass fraction that hardly enters the gel. This fraction, after separation by gel filtration and treatment with β-mercaptoethanol and urea, was shown by SDS-PAGE analysis to be formed by casein monomers. All sera analyzed by immunoblotting reacted against the components corresponding to casein monomers. Inhibition of immunoblotting by adsorption with different milk components confirmed that those high-molecular-mass aggregates are formed by casein components. The results presented here strongly suggest that casein is the major allergenic component of cow's milk.
Abstract 5194: Epigenomic and transcriptional profiling of CRC cell lines with distinct response patterns to the BET inhibitor BI 894999
Authors: Fabio Savarese, Daniel Gerlach, Larissa Koller, Susy Straubinger, Paula Elena Träxler, Onur Kaya, Norbert Schweifer, Ulrike Tontsch-Grunt, Norbert Kraut
Journal: Cancer Research (2019)

Abstract The bromodomain and extra-terminal (BET) protein BRD4 is a “reader” of epigenetic information and binds to acetylated chromatin. BRD4 acts as key regulator of transcriptional elongation by activating P-TEFb at distinct genes. It is via this specific activation of potentially oncogenic transcripts, e.g. MYC, that BRD4 is thought to contribute to tumorigenesis. Inhibition, via so-called BET inhibitors, has indeed proven to be a novel and attractive treatment option tested in ongoing clinical trials for both hematological as well as solid cancers. While BET inhibition shows good efficacy in pre-clinical models of hematological indications, solid tumors show much more heterogeneous responses to monotherapy. Consequently, biomarkers predicting response to treatment with BET inhibitors are of high interest. Colorectal cancer (CRC) is a heterogeneous disease in which novel treatment options are urgently needed. Our pre-clinical studies show that the BET inhibitor BI 894999 is highly active in a fraction of cell lines tested. H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) and transcriptional profiling of sensitive and resistant cell lines identified a small set of H3K27ac peaks associated with sensitivity to BET inhibition. Much of the transcriptional response in CRC cell lines however was cell line specific, leading to only few commonly regulated genes within sensitive versus resistant cell lines. Regarding pharmacodynamic biomarkers in CRC, we could confirm modulation of HEXIM1 after treatment in both sensitive and resistant cell lines. In agreement with previous results (Cohen et al, Nature Comm. 2017), we identified AP1 binding sites in BRD4-bound regulatory regions, which indicates that BRD4 may regulate expression of these genes cooperatively with the transcription factor AP1. Furthermore, the transcription factor TCF4 showed enrichment, suggesting possible interactions between BRD4 and the WNT pathway in a subset of CRC cell lines. The AXIN1, a core WNT pathway component, e.g. is down-regulated in 5/9 cell lines, which however does not track with overall BI 894999 sensitivity. These results, further supporting heterogeneous responses to single-agent BETi treatment, will be discussed. These studies support the further evaluation of BI 894999 as a therapeutic option for colorectal cancer therapy. Citation Format: Fabio Savarese, Daniel Gerlach, Larissa Koller, Susy Straubinger, Paula Elena Träxler, Onur Kaya, Norbert Schweifer, Ulrike Tontsch-Grunt, Norbert Kraut. Epigenomic and transcriptional profiling of CRC cell lines with distinct response patterns to the BET inhibitor BI 894999 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5194.
The AMA and the Federal Government. A study in changing relationships
Authors: C. L. Hudson
Journal: JAMA (1966)

Two factors make it a pleasure for me to appear today before this House of Delegates. First, it has been 22 weeks since I have had the privilege of being with you. At that time, having been inaugurated President of the Association, I expressed my appreciation to you for the honor you had bestowed upon me. Now, with five months of experience in the office behind me, I wish to repeat that expression of appreciation. Being President of this Association has given me an opportunity that I would never otherwise have had, to travel our nation and some other parts of the world, to meet with thousands of our fellow physicians and other thousands of laymen, and most important, to try to the best of my ability to bring to all of them the story of the American Medical Association as you would wish to have that story told. For
Early Clinical Experience With Heart Pump Reported
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TNF toxicity?death from caspase or cathepsin, that is the question
Authors: M CZAJA
Journal: Hepatology (2001)

TNF-induced apoptosis is thought to involve mediators from acidic vesicles.Cathepsin B (cat B), a lysosomal cysteine protease, has recently been implicated in apoptosis.To determine whether cat B contributes to TNF-␣-induced apoptosis, we exposed mouse hepatocytes to the cytokine in vitro and in vivo.Isolated hepatocytes treated with TNF-␣ in the presence of the transcription inhibitor actinomycin D (AcD) accumulated cat B in their cytosol.Further experiments using cell-free systems indicated that caspase-8 caused release of active cat B from purified lysosomes and that cat B, in turn, increased cytosol-induced release of cytochrome c from mitochondria.Consistent with these observations, the ability of TNF-␣/AcD to induce mitochondrial release of cytochrome c, caspase activation, and apoptosis of isolated hepatocytes was markedly diminished in cells from CatB -/-mice.Deletion of the CatB gene resulted in diminished liver injury and enhanced survival after treatment in vivo with TNF-␣ and an adenovirus construct expressing the IB superrepressor.Collectively, these observations suggest that caspase-mediated release of cat B from lysosomes enhances mitochondrial release of cytochrome c and subsequent caspase activation in TNF-␣-treated hepatocytes.
Health Professionals Persecuted in Violation of Their Human Rights: A Partial List of Cases
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retinal injury and detachment in boxers
Authors: J. I. Maguire
Journal: JAMA (1986)

From March 1983 to October 1985, the members of the Retina Service of the Wills Eye Hospital treated nine boxers with traumatic retinal injuries. Eight of these had retinal detachments requiring scleral buckling procedures. The ninth had a large tear without subretinal fluid that was treated with cryotherapy alone. In this article the authors describe the type and location of retinal injury, initial and follow-up treatment, and associated ocular findings and the mechanism of injury. (<i>JAMA</i>1986;255:2451-2453)
Total Hip Replacement
Authors: John Charnley
Journal: JAMA (1974)

This is an historic account of the development of total hip replacement as it took place in the author's laboratories and surgical clinics from about 1954 to the present time. The study covers five phases: basic research into the lubrication of normal animal joints; the trial of polytef as a low-friction plastic for the hip socket; bonding of implants to living bone by quick-setting acrylic cement; introduction of high-density polyethylene as a successful plastics material for the hip socket; and the attempt to identify a cause of late failure, when the probable alternatives were chemical rejection or bacterial infection, by eliminating airborne infection. (<i>JAMA</i>230:1025-1028, 1974)
Effects of Lead and Natriuretic Hormone on Kinetics of Sodium-Potassium-Activated Adenosine Triphosphatase: Possible Relevance to Hypertension
Authors: Elmar Weiler, Farhad Khalil-Manesh, Harvey Gonick
Journal: Environmental Health Perspectives (1988)

Inhibition of vascular smooth muscle sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) has been postulated as a central mechanism in enhancing vascular contractility. In the present study, kinetics of inhibition of Na-K-ATPase by lead, ouabain, and natriuretic hormone (NH) was studied in a purified hog cerebral cortex enzyme preparation. Determination of I50 values for lead, ouabain, and NH revealed that NH is the most potent inhibitor of the enzyme system (0.8 x 10(-6) M ouabain equivalents). Kinetic analyses indicated that lead and NH exhibited different inhibitory mechanisms. The inhibition by lead was noncompetitive with respect to potassium and competitive with respect to sodium and MgATP. Natriuretic hormone was noncompetitive with respect to potassium, uncompetitive with respect to MgATP, and exhibited no inhibitory effect with respect to sodium. Synergism between lead and NH in the inhibition of Na-K-ATPase raises the possibility that lead may be a contributory factor in hypertension via this mechanism.
Effects of dexamethasone on leukotriene synthesis and airway responses to antigen and leukotriene D4 in rats.
Authors: W S Powell, L J Xu, J G Martin
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Cysteinyl-leukotrienes (cysteinyl-LTs) are important mediators of both early and late allergen-induced airway responses in atopic asthmatics. We have investigated the effects of glucocorticoids on the in vivo synthesis of cysteinyl-LTs and airway responses to these mediators. Ovalbumin (OA)-sensitized Brown Norway rats, which exhibit early responses and, in most cases, also late responses to late antigen challenge, were treated with either one dose (1 h before antigen challenge) or two doses (2 and 14 h before challenge) of dexamethasone (dex; 300 micrograms/kg). A third group of sensitized rats which did not receive dex served as control animals. All rats were subjected to bile duct cannulation and tracheal intubation 2 h before intratracheal instillation of OA. All of the OA-treated control rats had pronounced early responses (5.5 +/- 1.0 times baseline pulmonary resistance [RL]), whereas 5 of 7 rats had late responses. Biliary levels of N-acetyl-LTE4 increased in all control rats following antigen challenge with a maximum occurring between 1 to 2 h, followed by a decline. There appeared to be a second maximum between 6 to 7 h after challenge, although this could not be demonstrated statistically because of the variability in the response among animals. Treatment with two doses of dex reduced the early response by 57%, completely eliminated the late response, and reduced the levels of N-acetyl-LTE4 in bile by about 80% at all time points.(ABSTRACT TRUNCATED AT 250 WORDS)
THE ISLET EMPIRE
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gonococcal osteomyelitis. An unusual complication of gonococcal arthritis
Authors: N. M. Gantz
Journal: JAMA (1976)

GONOCOCCAL arthritis, which usually responds readily to appropriate antimicrobial therapy, is a potentially destructive process. Before the introduction of antimicrobial agents, 23% to 85% of patients who recovered from gonococcal arthritis had residual joint damage.<sup>1</sup>Although osteomyelitis has been described as a complication of infective arthritis caused by bacteria other than the gonococcus, it has been infrequently associated with gonococcal arthritis. We report the case of a young woman who had gonococcal arthritis with contiguous osteomyelitis. <h3>Report of a Case</h3> A 31-year-old woman was admitted to Boston City Hospital with pain and swelling of the second right metacarpophalangeal joint. She was well until six weeks prior to admission, when she noted pain in the left hand and shoulder and in both wrists. Four weeks prior to admission, she came to the emergency room because of pain and swelling of the second, third, and fourth left metacarpophalangeal and proximal interphalangeal joints.
Tabulae Biologicae.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal