tbuckley/cabot-search huggingface dataset:
Tumors of the Spinal Cord. The Symptoms of Irritation and Compression of the Spinal Cord and Nerve Roots. Pathology, Symptomatology, Diagnosis and Treatment.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE JOURNAL IN 1895 AND 1896.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
p53 Mutations Associated with Breast, Colorectal, Liver, Lung, and Ovarian Cancers
Authors: Tamar Lasky, Ellen Silbergeld
Journal: Environmental Health Perspectives (1996)

In this paper we describe a statistical analysis of the European Molecular Library p53 mutation database comparing p53 mutations occurring in breast, colorectal, liver, lung, and ovarian cancers. The analyses show that mutation hot spots vary by cancer and that base pair changes and predicted amino acid changes in the gene product vary by cancer and by codon. The analyses use relative frequencies and epidemiologic measures of effect (prevalence ratios) not applied previously to these data. The five cancers in the database with the largest sample sizes were breast (418), colorectal (398), liver (341), non-small cell lung (313), and ovarian cancers (251), for a total of 1,721 reports of p53 mutations. The five cancers varied considerably in the distribution of mutations over sites, with different hot spots in each cancer. At the six most frequently reported codon sites, we compared base pair and amino acid changes by type of cancer. The comparison of base pair changes indicated a predominance of particular base pair changes at a codon (for example, C-->T and G-->A changes at Codon 248) and their association with specific cancers (C-->T changes with colorectal cancer and G-->A changes with both colorectal and breast cancers at codon 248). Comparing predicted amino acid changes by codon and cancer was also intriguing, as in codons 175 and 273, where arginine to cysteine and arginine to histidine changes were frequent in breast, colorectal, and ovarian cancers. Variations in p53 mutational distributions by cancer may be explained by different exposures to carcinogens or by organ-specific clonal selection. Further research may be stimulated by this analysis.
Contents page
Authors: Alan Sanfey, Karen Emmorey, Margaret Wilson, C Tallon-Baudry, Lucia Vaina, Scott Beardsley, Simon Rushton, Johannes Zanker, Alan Leslie, Ori Friedman, Tim German, Michael Siegal, Luca Surian, Matthew Botvinick, Jonathan Cohen, Cameron Carter, Katsuyuki Sakai, Okihide Hikosaka, Kae Nakamura, Michael Arbib, Jean-Marc Fellous Trendsin, Julian Ogilvie, Arthur Wadsworth, Manager Moulton
Journal: Trends in Cognitive Sciences (2004)
Environmental and familial contributions to insulin levels and change in insulin levels in middle-aged women
Authors: R. R. Wing
Journal: JAMA (1992)

<h3>Objective.</h3> —To examine familial and environmental variables associated with elevated insulin levels and changes in insulin levels in healthy, premenopausal women. <h3>Methods.</h3> —A population-based sample of 518 women (aged 42 to 50 years) completed baseline assessments of weight, cardiovascular risk factors, exercise behaviors, and glucose and insulin levels (fasting and 2 hours after a glucose load); 495 of the women were reevaluated after 3 years. <h3>Results.</h3> —Plasma insulin levels were related to weight, activity level, race, body fat distribution, and weight gain since age 20 years. Parental history of either diabetes or hypertension was also related to elevated insulin levels, independent of body mass index, with the highest insulin levels occurring in those women with a parental history of both diseases. Increases in plasma insulin levels over the years of follow-up were related to weight gain. <h3>Conclusions.</h3> —This study suggests the importance of using family history to identify women who may have elevated insulin levels and of intervening to prevent weight gain during middle age. (<i>JAMA</i>. 1992;268:1890-1895)
Alcoholic Cardiomyopathy
Authors: STEVEN HERSON
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 September 1971Alcoholic CardiomyopathySTEVEN HERSONSTEVEN HERSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-3-479_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I found the article, "Alcoholic Cardiomyopathy Managed with Prolonged Bed Rest" (Ann Intern Med 74:681-691, 1971), to be of interest with respect to the clinical features of the disease. I fail to see, however, how the value of bed rest was demonstrated. Abstinence from alcohol was probably the most important factor relating to what improvement was noted. Perhaps if there were control patients, ambulatory after the first few weeks, the role of prolonged bed rest could have been appreciated.Would that we had the resources to accommodate all alcoholics with severe medical complications of their disease in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical College of Virginia Richmond, Va. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1971Volume 75, Issue 3Page: 479-479KeywordsAlcoholicsAlcoholsCardiomyopathies Issue Published: 1 September 1971 PDF downloadLoading ...
Contents, Vol. 60, No. 1, 1993
Authors: Dirk H. Hellhammer, Dirk H. Hellhammer, Stephen Wade, Hendrik Lehnert, Richard J. Wurtman, Seymour Levine, Laurel A. Fisher, Marvin R. Brown, David L. Felten, Suzanne Y. Felten, Denise L. Bellinger, Kelley S. Madden
Journal: Psychotherapy and Psychosomatics (1993)
Reply to Henk G. van der Poel, Tessa Buckle and Renato Valdes Olmos’ Letter to the Editor re: Steven Joniau, Laura Van den Bergh, Evelyne Lerut, et al. Mapping of Pelvic Lymph Node Metastases in Prostate Cancer. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2012.06.057
Authors: Steven Joniau, Laura Van den Bergh
Journal: European Urology (2012)
Autologous transfusion
Authors: H. Silver
Journal: JAMA (1976)

ONE DAY a middle-aged married couple came to the blood bank requesting that a unit of blood be drawn from the husband. The wife was scheduled for surgery in ten days and the blood to be drawn was to be kept for possible use at that time. Although the woman had been told that there was only a remote possibility that a transfusion would be required she thought that if she were to get any blood she wanted it to be "safe" blood from someone she thought had not had hepatitis or any other disease with which she could be infected through transfusion. Her fears were prompted by recent federal interest in hepatitis transmission through blood, as well as by malpractice cases concerned with instances of hepatitis resulting from blood transfusion (all of which have been covered in depth by newspapers and other lay publications). It was soon learned that
Editorial: Comment of hyperbole: statement of the Drug Research Board
Authors: J. D. Archer
Journal: JAMA (1975)

At the risk of being repetitious, we feel obliged to return to a theme explored repeatedly in past issues ofThe Journal.<sup>1-4</sup>This situation reminds me (R.H.M.) of an experience that occurred during my army years. I was attending the Army Command and General Staff College at Fort Leavenworth. On the first day in our nervously chattering class of Military Map Reading, in strode an impressive full colonel: elegant, beribboned, and ramrod erect. He stared sternly at the large group. Then he spoke in measured words, "Gentlemen, I am Colonel Jones, your instructor in map reading. I wish to state at the outset of this course, that at all times, I reserve the right to use the terms<i>north</i>and<i>south</i>interchangeably!" This ice-breaking introduction is reminiscent of the ambiguous, mad-hatterish resolution of the Drug Research Board of the National Research Council (NB: the final paragraph): WHEREAS, The patient's
Pneumonia, History
Authors: Robert J. T. Joy
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentaire de travail de A. Meining et al., pp. 345
Journal: Endoscopy (2007)

See also: The effect of sedation on the quality of upper gastrointestinal endoscopy: an investigator-blinded, randomized study comparing propofol with midazolamEndoscopy 2007; 39(04): 345-349DOI: 10.1055/s-2006-945195
Genetic alterations at the splice junction of p53 gene in human hepatocellular carcinoma
Authors: H Hsu
Journal: Hepatology (1994)

The tumor-suppressor gene p53 may transactivate the transcription of genes that down-regulate cellular growth-related genes and may become oncogenic as a result of the production of mutant proteins or the loss of its protein expression. This study reports that alterations of the highly conserved consensus intervening sequences at the splice junctions may lead to the inactivation of the p53 gene. Analyses with the combined polymerase chain reaction and single-strand conformational polymorphism and direct DNA sequencing of DNAs amplified by means of asymmetric polymerase chain reaction demonstrated sequence alterations at the splice junctions of introns 5 and 7 in four human hepatocellular carcinomas, with a single base substitution at the splice junction in three and a 10-bp deletion starting from the dinucleotide AG of the acceptor site of intron 5 in the fourth. Restriction fragment length polymorphism analysis disclosed allele loss in all three informative cases. The p53 mRNA concentrations were remarkably reduced or undetectable in two hepatocellular carcinomas, whereas the two tumors (cases 2 and 3) that had single base changes at the acceptor site of intron 7 had both normal and abnormally sized p53 mRNAs. Immunocytochemistry failed to detect the wild-type and mutant p53 proteins in all four tumors. Western-blot analysis disclosed an abnormal, larger p53 protein of 55 kD in the tumor of case 3. These findings suggest that the inactivation of p53 gene caused by the genetic alterations at the splice junction may occur more often than perceived and plays an important role in human hepatocarcinogenesis because of the inactivation of the p53 gene by way of the loss of the protein or production of an abnormal protein. (Hepatology 1994; 19:122–128).
Editorial Board
Authors: Bruce Thiers, Dirk Elston, Detra Davis, Anna Krueger, Jack Lesher, Kenneth Katz, Mary Spellman, Jeffrey Weinberg, Dermatologic Surgery, Clifford Perlis, Julie Prendiville, Frcpc Dermatopathology, John Maize, Robert Dellavalle, J Smith
Journal: Journal of the American Academy of Dermatology (2014)
Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma
Authors: D. L. Hahn
Journal: JAMA (1991)

<h3>Objective.</h3> —To study the clinical characteristics of respiratory tract illness caused by<i>Chlamydia pneumoniae</i>. <h3>Design.</h3> —Prospective clinical, bacteriologic, and serologic study. Secondarily, a matched comparison of patients with and without evidence of<i>C pneumoniae</i>infection (serologic titers ≥1:64 and &lt;1:16, respectively). <h3>Setting.</h3> —Four primary care (family practice) clinics in Madison, Wis, and nearby towns. <h3>Patients.</h3> —The study included 365 white males and females (mean age, 34.2 years). <h3>Main Outcome Measures.</h3> —Association of acute<i>C pneumoniae</i>infection with signs and symptoms of respiratory illness and the relationship of<i>C pneumoniae</i>antibody titer with wheezing at the time of enrollment in the study, and with the diagnosis of asthmatic bronchitis. <h3>Results.</h3> —Nine (47%) of 19 patients with acute<i>C pneumoniae</i>infection had bronchospasm during respiratory illness, and there was a strong quantitative association of<i>C pneumoniae</i>titer with wheezing at the time of enrollment in the study (<i>P</i>=.01). In the matched study,<i>C pneumoniae</i>antibody was significantly associated with asthmatic bronchitis after, but not before, respiratory illness (odds ratio, 7.2; 95% confidence interval, 2.2 to 23.4). Four infected patients had newly diagnosed asthma after illness, and four others had exacerbation of previously diagnosed asthma. There was no serologic evidence of coexisting<i>Mycoplasma pneumoniae, Chlamydia trachomatis</i>, or respiratory viral infection in 96% of patients with asthmatic bronchitis and asthma. <h3>Conclusions.</h3> —Some<i>Cpneumoniae</i>antibody titers, although not diagnostic of chlamydial infection by present criteria, probably represent acute reinfection or ongoing chronic infection. Repeated or prolonged exposure to<i>C pneumoniae</i>may have a causal association with wheezing, asthmatic bronchitis, and asthma. (<i>JAMA</i>. 1991;266:225-230)
Sputum Digestion and Decontamination with N-Acetyl-L-Cysteine-Sodium Hydroxide for Culture of Mycobacteria
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bile ductule formation in fetal, neonatal, and infant livers compared with extrahepatic biliary atresia
Authors: J Cocjin
Journal: Hepatology (1996)

The cell of origin of intrahepatic bile ducts during fetal development remains a subject of controversy, although there has been recent evidence that they form from hepatocytes. However, the origin of neoductules and ducts in the setting of liver disease has not been extensively investigated in humans. Using anticytokeratins characteristic of hepatocytes and bile ducts, we repeated earlier studies of fetal development to compare ductule formation in normal developing and newborn livers with the ductules formed during extrahepatic biliary atresia. We utilized an antibody to proliferating cell nuclear antigen (PCNA) staining to determine which cells were in active DNA synthesis (S phase) during fetal development and liver disease progression. The results indicated that hepatocytes undergo a phenotypic switch (metaplasia) to form ductular cells during fetal development. There was no ductular cell replication in the fetal livers. In contrast, both bile ductular metaplasia and proliferation were observed in biliary atresia. Therefore, both a limiting plate phenotypic switch to ductules and replication of ductular cells play a role in the increase in the ductules seen in the progression to biliary cirrhosis. Bile ductular proliferation in biliary atresia, however, was less than that seen in hepatocytes, whereas the number of bile ductules increased and the relative proportion of hepatocytes diminished as the accompanying periductular fibrosis progressed to cirrhosis.
Book Review Hutchison's Food and the Principles of Dietetics . Revised by V. H. Mottram, M.A. (Cant.), and George Graham, M.D. (Cant.), F.R.C.P. (Lond.). Ninth edition. 8°, cloth, 648 pp., with 30 illustrations. Baltimore: Williams and Wilkins Company, 1940. $6.75.
Journal: New England Journal of Medicine (1941)
Midcourse Correction
Authors: Allan L Drash
Journal: Diabetes Care (1993)

I last communicated directly with you 18 months ago in the January 1992 issue of Diabetes Care—the first issue of the journal under the editorial direction of the Pittsburgh Group. That editorial was written at poolside in late August 1991 as the hand-over process from Dr. David Robbins and his excellent group of associate editors began.
The Right of Privacy Protects the Doctor-Patient Relationship-Reply
Authors: George J. Annas
Journal: JAMA (1990)

<h3>In Reply.—</h3> Our article was an effort to explain why the abortion cases and legislation have much wider implications for physicians and patients than is generally recognized. Dr Lytle's letter is an example of how focusing on abortion rather than general legal principles causes one to overlook these implications. In his zeal to condemn abortion, Dr Lytle distorts what we wrote. We did not say that the actions of physicians can never be regulated by law. We said, "Obviously, the state can regulate medical practice.... Legitimate medical regulation generally requires reference to the safety, efficacy, or cost of the procedure at issue." It is these concerns that justify narcotics laws. The prohibition of abortion is related to none of these legitimate concerns, but rather is the imposition of moral beliefs of some on others who do not share those beliefs. Dr Lytle also implies that we oppose the doctrine of
DOMESTIC CORRESPONDENCE.
Authors: T. B. Hill
Journal: JAMA (1892)

<h3>Thyroid Dislocation of the Femur, with Integrity of the Ileo-femoral Ligament.</h3><h3>To the Editor of the Journal of the American Medical Association</h3> Believing the following to be a rare, if not unique form of accident I am Induced to report it: On the morning of Nov. 20, 1891, Hugh Taylor, age 7, fell from the back of a mule. As no one saw the fall, it cannot be told how he struck the ground, but he was unable to arise on account of injury to the left hip. I saw him two hours after the accident, and found him lying upon his back inclined to the left side. His left leg was flexed upon the thigh, and the thigh flexed upon the trunk to an acute angle, and abducted to such an extent as to rest easily upon the bed, in the position he had assumed, without any extra support.
PROGNOSIS IN VALVULAR HEART DISEASE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal