tbuckley/cabot-search huggingface dataset:
Effect of Intermittent Exposure to Sunlight on Melanoma Risk among Indoor Workers and Sun-Sensitive Individuals
Authors: Patty J. Nelemans, Hennie Groenendal, Lambertus A. L. M. Kiemeney, Frans H. J. Rampen, Dirk J. Ruiter, Andre L. M. Verbeek
Journal: Environmental Health Perspectives (1993)

Intermittent exposure to sunlight is considered to be an important risk factor for melanoma, but the associations reported in most case-control studies are surprisingly weak. The aim of this study was to evaluate whether the incorporation of a subject's background exposure to the sun and pigmentation characteristics (which are assumed to influence a person's susceptibility to sunlight exposure) could produce stronger associations between sunlight exposure and the risk for melanoma. A population-based case-control study was performed in the mid-eastern part of the Netherlands. The study group comprised 141 patients with a histologically verified melanoma and 183 controls with other malignancies who were registered by the same cancer registry. Patients with a lentigo maligna melanoma or an acrolentiginous melanoma were excluded. Information was collected by interviews and physical examination. We categorized subjects as indoor or outdoor workers on the basis of occupational exposure to the sun. Pigmentation characteristics, which are known to be risk indicators for cutaneous melanoma, were summarized as one sun sensitivity score. We used this score to distinguish between sun-sensitive and sun-resistant persons. The odds ratios associated with sunbathing, vacations spent in sunny countries, and sunburns were higher among the indoor workers than among the outdoor workers. After stratification by the sun sensitivity score, the effect of sunbathing, participating in water sports (swimming excluded), vacations to sunny countries, and a history of sunburn was largest for the sun-sensitive persons. The data show a general trend toward higher relative risks among indoor workers and sun-sensitive individuals. The results of this study support the intermittent sunlight hypothesis.
GONORRHEAL ARTHRITIS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
619. Tumor-Derived Chemokine MCP-1/CCL2 Is Sufficient for Mediating Tumor Tropism of Adoptively Transferred T-Cells
Authors: Christine E. Brown, Reena Vishwanath, Brenda Aguilar, Wen- Chung Chang, Michael C. Jensen
Journal: Molecular Therapy (2006)

To exert a therapeutic effect, adoptively transferred tumor-specific cytotoxic T-cells must traffic to sites of metastatic disease, exit the circulation, and infiltrate the tumor microenvironment. Here we examine the intrinsic ability of adoptively transferred human cytolytic T lymphocytes (CTL) to traffic to tumors with disparate chemokine secretion profiles. Using a combination of in vivo tumor tropism studies, and in vitro biophotonic chemotaxis assays, we observed that glioma, but not 10HTB neuroblastoma or Daudi lymphoma tumor cell lines, preferentially chemoattracted ex vivo expanded primary human T-cells. We compared the chemokine species secreted by tumor lines with high chemotactic activity (gliomas) with those that failed to elicit T-cell chemotaxis (neuroblastoma and lymphoma), and found a correlation between high concentrations of MCP-1/CCL2 with T-cell chemotaxis. MCP-1 is sufficient for in vivo T-cell tumor tropism as evidenced by the selective accumulation of intravenous administration firefly luciferase-expressing T-cells in intracerebral xenografts of tumor transfectants secreting MCP-1. We demonstrate cerebrally implanted human T-cells are capable of trafficking through the brain parachema to the contralateral hemisphere to sites of U87 glioma tumor burden. Furthermore, glioma specific T-cell were shown to eliminate U87 tumors xenografted ipsilateral to their injection site then effect tumor reduction in the contralateral hemisphere. These studies suggest the capacity of adoptively transferred T-cells to home to and efficiently eliminate tumors may be, in part, dictated by the species and amounts of tumor-derived chemokines, in particular MCP-1.
Obituary
Authors: Joseph B. Kirsner
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe Hyponatremia After Drinking Horsetail Juice
Authors: Chloe C.A. Grim
Journal: Annals of Internal Medicine (2019)

Letters7 May 2019Severe Hyponatremia After Drinking Horsetail JuiceChloe C.A. Grim, MD, MScChloe C.A. Grim, MD, MScHaga Hospital, the Hague, the Netherlands (C.C.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0072 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We saw remnants of the plant that the patient consumed and were convinced that it was horsetail. Although we do not know the exact amount of horsetail the patient ingested, her husband described it as a full glass of “pure” horsetail juice (that is, the whole plant was juiced, and no additives were used). We suspect that that the patient ingested a much higher dose than the 900 mg used in Carneiro and colleagues' trial.Patients with pure water intoxication have low urinary osmolality, whereas this patient's urinary osmolality was high. This finding indicates that she had SIADH, ... Author, Article, and Disclosure InformationAffiliations: Haga Hospital, the Hague, the Netherlands (C.C.G.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0028. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSevere Hyponatremia After Drinking Horsetail Juice Chloe C.A. Grim , Iwan A. Meynaar , Sebastiaan Hammer , and Darius Soonawala Severe Hyponatremia After Drinking Horsetail Juice Matthew R. Norris Metrics 7 May 2019Volume 170, Issue 9Page: 668KeywordsDisclosureHyponatremiaIngestionIntoxicationSyndrome of inappropriate antidiuretic hormone secretion ePublished: 7 May 2019 Issue Published: 7 May 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Response
Authors: EDWARD A. SICKLES, DANIEL B. KOPANS
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Response Get access EDWARD A. SICKLES, EDWARD A. SICKLES Search for other works by this author on: Oxford Academic PubMed Google Scholar DANIEL B. KOPANS DANIEL B. KOPANS Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 7, 6 April 1994, Pages 559–560, https://doi.org/10.1093/jnci/86.7.559 Published: 06 April 1994
Etiological Factors
Authors: Warren L. Bostick
Journal: JAMA (1964)

IN DISCUSSING the relationships between that segment of the medical profession which is busy producing medical students and that busy practicing medicine, one is reviewing an area that has often been contemplated and frequently named —the "Town and Gown" rhyme is pleasing; Dr. Hussey's "Preceptors, Practitioners, and Problems" catches the ear; Burton Rouche's "Part-Time, Full-Time, High-Time," spots one aspect of the problem and accents its urgency. Any social situation having symptoms that often occur in groups can most appropriately be placed in that medical cluster known as a syndrome. Although this intersocial phenomenon has been reported with various manifestations, it nonetheless, from an otiological point of view, has certain very definite characteristics that permit it to be profitably analyzed in genetic terms. This hereditary trait is found in the genome of that social organization known as "a city which has a university." It can be manifest by various colleges of
Visual White Matter Integrity in Schizophrenia
Authors: Pamela Butler
Journal: American Journal of Psychiatry (2006)

Objective: Patients with schizophrenia have visual-processing deficits. This study examines visual white matter integrity as a potential mechanism for these deficits. Method: Diffusion tensor imaging was used to examine white matter integrity at four levels of the visual system in 17 patients with schizophrenia and 21 comparison subjects. The levels examined were the optic radiations, the striate cortex, the inferior parietal lobule, and the fusiform gyrus. Results: Schizophrenia patients showed a significant decrease in fractional anisotropy in the optic radiations but not in any other region. Conclusions: This finding indicates that white matter integrity is more impaired at initial input, rather than at higher levels of the visual system, and supports the hypothesis that visual-processing deficits occur at the early stages of processing.
Therapeutic Biliary Endoscopy
Authors: S. K. Shah, M. Mutignani, G. Costamagna
Journal: Endoscopy (2002)

An analysis of the recent medical literature on therapeutic biliary endoscopy shows that the new millennium has already brought several significant developments. However, although advances continue rapidly, several new questions have also arisen, paving the way for further research. Several studies during the last year have also focused attention on cost-effectiveness.
Hypothermia-Related Deaths— Vermont, October 1994-February 1996
Journal: JAMA (1997)

Hypothermia is a lowering of the core body temperature to < or = 95 F (< or = 35 degrees C). From 1979 through 1992, a total of 10,550 persons in the United States died from hypothermia, an average of 754 deaths per year (range: 557-1021 deaths). From October 1994 through February 1996, a total of 10 hypothermia-related deaths were reported by the chief medical examiner in Vermont. The average age of the 10 decedents was 62 years (range: 18-88 years); eight were men. Seven decedents were reported to have had histories of mental illness, and alcohol abuse was mentioned on the police or pathology report for two decedents. This report summarizes the investigation of three of these deaths and describes risk factors commonly associated with hypothermia.
Narcotics and Medical Practice
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Moses Maimonides
Authors: Solomon E. Barr
Journal: New England Journal of Medicine (1954)

ALTHOUGH Moses Maimonides was one of the most famous physicians of his day he was even better known as a philosopher, leader and scholar.He was born in 1135 in Moslem-controlled Cordova, Spain, the eldest son of Maimon, a local judge. When Moses was thirteen a fanatic new Moslem sect, the Alhomades, conquered his native city. Because of the ensuing religious persecution he and his family were forced to flee to Morocco. However, conditions were no better there, and ten years later the family again fled, this time to Fostat, Egypt, a suburb of Cairo. There the family engaged in . . .
More voices join medicine in expressing concern over amount, content of what children see on TV
Authors: J. W. Zylke
Journal: JAMA (1988)

VICTOR STRASBURGER, MD, who heads an adolescent medicine division, tells about running into the maker of one of the sexiest music videos he'd ever seen. Strasburger commented that he couldn't understand why the man had made such a film, and the filmmaker replied that now he didn't understand it either. Why the change of heart since making it? He now has a daughter. Like the filmmaker, many parents are concerned about what their children watch on television. That concern continues to be shared by medical organizations and increasingly is coming to the attention of lawmakers. <h3>1988-1989 "Season"</h3> There is little question, as a "new television season" begins, that this medium is a pervasive influence in the lives of children today. By age 15 years, most youngsters will have spent more hours in front of a television set than in school. They will have spent more hours on only one other
Noncontraceptive estrogen use and the risk of breast cancer
Authors: D. W. Kaufman
Journal: JAMA (1984)

The relation between the risk of breast cancer and the use of noncontraceptive estrogens was investigated in a hospital-based study of 1,610 women with breast cancer and 1,606 with other conditions. The overall relative risk estimate for conjugated estrogens first taken at least 18 months before admission, compared with never-use of any noncontraceptive estrogens, was 0.9 (95% confidence interval, 0.7 to 1.1). For other estrogens first taken at least 18 months before admission, the estimate was 0.8 (0.6 to 1.1). The results were similar when known risk factors for breast cancer were taken into account. Among postmenopausal women, conjugated estrogens did not appear to increase the risk of breast cancer, even when taken for many years or in the distant past. There was no evidence of an increased risk due to conjugated estrogen use among subgroups of women defined according to various risk factors for breast cancer. The results of this study suggest that noncontraceptive estrogens do not increase the risk of breast cancer. (<i>JAMA</i>1984;252:63-67)
Richerson, Not Richardson
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AN INTRODUCTION TO THE STUDY OF PNEUMONIC FEVER.
Authors: EDWARD F. WELLS
Journal: JAMA (1889)

A disease characterized by the striking peculiarities of pneumonic fever must necessarily have attracted the attention of the disciples of our art from the very dawn of Medicine. That such was indeed the fact we know from the distinct allusions to it found in the most ancient of the writings of antiquity which have been handed down to us. It is true, however, that being comparatively ignorant of the relations existing between the clinical phenomena and the anatomical alterations of diseases, and of physical diagnosis, it was simply impossible for the physician of old to accurately differentiate the various acute diseases of the lungs, yet, inasmuch as the malady under consideration is the most common—excepting ordinary bronchial catarrh—most severe and most fatal—phthisis excepted—of these, we may infer, with much probability, that their words refer, for the greater part, to this affection. Later, when it became the custom to occasionally continue
Striking prognostic significance of elevated CRP in renal impairment patients undergoing PCI Mark A. Robbins, Derek P. Chew, Deepak L. Bhatt, Abdulhay Albirini, Leslie S. Cho, Jakob Schneider, Stephen G. Ellis, Eric J. Topol. Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)
Abstract 1989: Breast cancer-derived exosomes modulate the endocytic pathway in brain endothelial cells
Authors: Golnaz Morad, Christopher V. Carman, Marsha A. Moses
Journal: Cancer Research (2019)

Abstract Breast cancer brain metastasis is associated with high mortality and has shown a rising trend in incidence during the recent years. Given the rapid progression of brain metastasis, elucidation of the early events that lead to brain metastasis will pave the way to identifying potential diagnostic and therapeutic targets for early intervention. To explore the early mechanisms of breast cancer brain metastasis, we focused on the role of breast cancer-derived exosomes in this process. While extensive studies have explored the role of tumor-derived exosomes in tumor progression, the current understanding of the contribution of tumor-derived exosomes to brain metastasis remains limited. Using a mouse model of brain metastasis, we showed that pre-treatment of mice with exosomes derived from the brain-seeking MDA-MB-231 breast cancer cell line (Br-Ex) increases brain metastasis growth. This facilitation of brain metastasis was not observed with exosomes derived from the parental MDA-MB-231 cells (P-Ex). It is widely acknowledged that during early stages of brain metastasis, tumor cells grow along the brain vasculature, the blood brain barrier (BBB). To understand the mechanisms of the exosome-derived facilitation of brain metastasis, we studied the interactions between exosomes and the BBB. Using state-of-the-art models of the BBB and high-resolution microscopy, we have identified, for the first time, the mechanisms by which Br-Ex modulate the endocytic pathway in brain endothelial cells to decrease exosome degradation. Interestingly, our mechanistic studies showed that these effects are induced through the transfer of exosomal miRNAs enriched in Br-EX. Moreover, we have shown that Br-Ex can exclusively change the expression of integrins in brain endothelial cells in a way that it could alter the microenvironment around the BBB in favor of metastatic tumor cells. These findings indicate that exosomes derived from a brain-seeking subpopulation of breast cancer cells can exclusively modify the physiological regulation of the BBB at multiple levels to accelerate metastatic growth in the brain microenvironment. Taken together, these studies increase our understanding of the early events that facilitate brain metastasis and provide multiple potential targets for diagnostic and therapeutic applications in brain metastasis. (This work was supported by the Breast Cancer Research Foundation and NIH R01CA185530.) Citation Format: Golnaz Morad, Christopher V. Carman, Marsha A. Moses. Breast cancer-derived exosomes modulate the endocytic pathway in brain endothelial cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1989.
Medical Discipline
Authors: Bruce E. Vodicka
Journal: JAMA (1975)

THEORIES of criminal law and penology that place emphasis on rehabilitation rather than punishment of criminal offenders, coupled with a propensity to view suspension or revocation of professional licenses as punishment, have caused some confusion regarding the applicability of rules of criminal law to medical board proceedings. <h3>Entrapment</h3> In criminal cases, entrapment is an accepted defense to commission of a wrongful act. It is successfully advanced by proving that the offense charged would not have been committed except for the trickery, persuasion, or fraud of a law officer or paid informer. The essential elements of the defense are a lack of criminal intent by the defendant prior to his contact with the officer and inducement or procurement of a criminal act by the officer, resulting in a crime that otherwise would not have been committed. This defense is not grounded on constitutional provisions. Rather, it springs from the widely approved