tbuckley/cabot-search huggingface dataset:
Abstract 92: Cardiac Bridging Integrator 1 Gene Transfer Improves Left Ventricular Lusitropy in Mice With Continuous Infusion of Isoproterenol
Authors: Yan Liu, Kang Zhou, Sosse Agavanian, Bing Xu, Robin M Shaw, TingTing Hong
Journal: Circulation Research (2017)

Background: Cardiac bridging integrator 1(cBIN1) is a membrane scaffolding protein, which organizes t-tubule dyad microdomains critical for normal calcium transient development. BIN1 is transcriptionally reduced in heart failure, and reduced BIN1 diminishes calcium transients, limiting excitation-contraction coupling and impairing contractility. Furthermore, cBIN1-microdomains organize with acute β-adrenergic activation. It remains unclear whether over-expression of cBIN1 improves myocardial function in mice with chronic sympathetic overdrive. Methods: Adult male C57BL/6 mice received retro-orbital injections of adeno-associate virus 9 (AAV9) transducing either control GFP, sBIN1 (small BIN1), BIN1+13, BIN1+17, or cBIN1 (BIN1+13+17). Three weeks after virus injection, mice were subjected to subcutaneous implantation of micro osmotic pumps continuously releasing isoproterenol at 30mg /kg/day for four weeks. Left ventricular (LV) geometry and function were evaluated by echocardiography before and weekly after isoproterenol infusion. Results: In the control GFP group, isoproterenol infusion significantly increased LV mass and relative wall thickness (RWT), consistent with concentric hypertrophy. Over-expression of any of the four BIN1 isoforms attenuated left ventricular hypertrophy (n=5 per group). However, only cBIN1 over-expressing mice became more efficient. Their hearts had improved left ventricular relaxation, and were able to preserve ejection fraction yet with increased end systolic and diastolic volumes. As a result of improved relaxation, cBIN1 over-expression increased stroke volume and cardiac output without their hearts becoming hyperdynamic. Thus cBIN1 conveys a general BIN1 protection against isoproterenol induced hypertrophy together with a cBIN1 specific improvement in lusitropy. Conclusions: In mice with chronic sympathetic overdrive, over-expression of cBIN1 increases LV compliance, preserves heart lusitropy, and improves cardiac function. This athletic heart like phenotype induced by cBin1 gene therapy indicates that exogenous cBIN1 can reverse the diastolic dysfunction associated with sympathetic overdrive and heart failure progression.
Spotlight Issue on The TGFβ Superfamily in Cardiovascular Biology
Journal: Cardiovascular Research (2006)

A Spotlight Issue on the transforming growth factor ␤ (TGF␤) superfamily, comprising TGFβ itself, bone morphogenetic protein (BMP), activin, and other peptide cytokines, is scheduled to appear in May, 2007, that will address the critical role of these growth factors in cardiovascular development and physiology as well as in a variety of cardiovascular disease states, including atherosclerosis, ischemic heart disease, and heart failure.In addition, there will be detailed information on TGFβ receptors, modes of activation, and subsequent mechanisms of intracellular signaling.Putative targets of pharmacological intervention will also be covered.Preliminary topics of invited review articles related to the cardiovascular biology of the TGFβ superfamily include:
Food Conservation
Authors: J. Barcroft
Journal: BMJ (1939)

my own ulcer treatment it merely implies that this is the way in which we manage it in Denmark, at Bispebjerg Hospital, in my department.It consists of rest in bed, though not absolute, for four to five weeks, a soft non- irritating diet with increasing variety during the same period, frequent meals-that is to say, every second or third hour-alkali, and belladonna; tobacco is forbidden.How much importance attaches to the last restriction I shall not go into.We endeavour to make the diet qualitatively sufficient, but I must admit that in certain ways it perhaps leaves something to be desired, and it is con- ceivable that we ought to pay more attention to remedying possible vitamin deficiencies.On discharge from the hospital the patients are urged to avoid the most irritating kinds of food for six months, to continue taking frequent meals, to restrict the use of tobacco and not to let "a smoke " take the place of a snack between meals, and also to try to adopt a calmer attitude towards life and its incidents. SummaryThe treatment of bleeding ulcer is first discussed because experience with a free diet has influenced the outlook on ulcer treatment in general.The results of treating 491 cases of profusely bleeding ulcer are given.The conclusion drawn is that the more severe the bleeding the more the need for fluid and food.Operative treatment with a view to haemostasis is not advised.In non-bleeding ulcer it is maintained that use of a freer diet gives improved results ; treatment is supple- mented with alkalis and belladonna.The view is held that the basic principles of the general medical treatment of ulcer should be rest, relaxation, and adequate food taken at frequent meals.
Human Gamma Globulin: Genetic Control and its Relation to Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beautiful
Authors: David J. Malebranche
Journal: Annals of Internal Medicine (2017)

On Being a Doctor7 November 2017BeautifulDavid J. Malebranche, MD, MPHDavid J. Malebranche, MD, MPHFrom Morehouse School of Medicine, Atlanta, Georgia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M17-1916 Audio Reading - “Beautiful” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Beautiful," by D.J. Malebranche. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It's a blessing to see peopleWith their heads up to the sky still‘Cause honestly for the same peopleLife can be so real.—Mali MusicThe heat was stifling in the clinic that morning, and the underachieving air conditioner didn't seem to care. A typical day in our community HIV center was unfolding like the train wreck it often was. Staff bustled about, overworked and tragically underpaid, and the stench of social inequity bled from the walls while archaic systems persisted to frustrate both patients and staff alike. My nurse and I were stuck in the middle of this disarray, failing miserably ... Author, Article, and Disclosure InformationAffiliations: From Morehouse School of Medicine, Atlanta, Georgia.Corresponding Author: David J. Malebranche, MD, MPH, Morehouse School of Medicine, 720 Westview Drive, Atlanta, GA 30310; [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Beautiful” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Beautiful," by D.J. Malebranche. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 7 November 2017Volume 167, Issue 9Page: 679-680KeywordsChartsHIVHand strengthNursesPsychiatry and mental healthSuicideSweatTemperatureTriageViral load ePublished: 7 November 2017 Issue Published: 7 November 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Errors in Equation and Modeling Parameter
Authors: Samia Mora, Joann Manson
Journal: JAMA (2016)

for prevention.It is not intended to produce the correct or only decision but to facilitate the shared decision-making conversation by providing the tailored estimates of risk and benefit for the individual patient (instead of generalized population estimates).In the process of using the decision-support tool, the clinician and patient engage in a discussion that explores and compares the risk vs benefit information, elicits the patient's values and preferences, and makes the shared decision. 2-4Hence, the final patient-centered decision is made by the patient together with the clinician, based not only on the patient's risks and benefits, but incorporating the patient's preferences, values, concerns, and goals of care.
Reference Directories
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poetry
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
I have finished basic training in paediatrics, have completed my exams, and feel this is the right time for SpR applications. I have also been given the opportunity to apply for an excellent research fellow post, which would be of benefit in the long run. My concern is that if I miss out on an SpR number now for the sake of a three year research post I will be at a disadvantage when I apply for what will then be higher specialty training posts. Is research now a bad idea?
Authors: Howard Clark
Journal: BMJ (2006)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
Consensus conference. Differential diagnosis of dementing diseases
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Near-Tetraploidy in Childhood Acute Lymphoblastic Leukemias Does Not Adversely Affect Prognosis: An EGIL Retrospective Study On 36 Cases Petr Lemez, Andishe Attarbaschi, Marie-Christine Bene, Yves Bertrand, Gian-Luigi Castoldi, Erik Forestier, Richard Garand, Oskar A. Haas, Emmanuelle Homolle, Sandrine Kagialis-Girard, Wolf-Dieter Ludwig, Estella Matutes, Marie-Pierre Pages, Winfried Pickl, Anna Porwit, Alberto Orfao, Jan Stary, Herbert Strobl, Pascaline Talmant, Mars B. Van't Veer, Zuzana …
Authors: Petr Lemez
Journal: Blood (2009)
First Conference of the National Association of Oncology Social Workers
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article First Conference of the National Association of Oncology Social Workers Get access JNCI: Journal of the National Cancer Institute, Volume 74, Issue 4, April 1985, Page 953, https://doi.org/10.1093/jnci/74.4.953-a Published: 01 April 1985
Elusive EMFs.
Journal: Environmental Health Perspectives (1995)

I reduced number of blood vessels feeding the tumors in the embryos injected with the proteins.The tumors actually regressed and the embryos developed normally.In the control embryos, the blood vessels proliferated in their usual pattern, promoting the growth of the tumors."The research is very promising and has great potential," says James Pluda, an angiogenesis expert at the National Cancer Institute in Bethesda, Maryland.The experiment designed by the Scripps researchers "approaches disrupting the angiogenic pathway at a point that is different than other [studies have shown]," says Pluda."We're excited about having it progress," says Pluda, who oversees the development of anti-angiogenic drugs at NCI. "It's very interesting; it's also very preliminary," he cautions.The proteins could lead to unwanted side effects in other tissue, which could inhibit wound healing, for example, or possibly lead to fetal damage in pregnant women.At this stage of research, scientists at Ixsys are completing toxicology studies to determine the extent, if any, of adverse effects of the LM609 antibody.They will also perform tests to rule out any biological properties that would discourage the use of the antibody in humans.According to Brooks, the Scripps research team duplicated their chickembryo test results in experiments on small sections of human skin grafted onto mice and observed a twofold reduction in tumor size.Their laboratory findings held true for a broad range of solid-tumor human can- cers, including malignant melanomas and cancers of the lung, breast, pancreas, brain, and larynx.According to Brooks, the team collabo- rated with another Scripps researcher, ophthalmologist Martin Friedlander, and dis- covered that the protein therapy may be useful in treating several eye disorders as well, including diabetic retinopathy and macular degeneration.
CARDIOPULMONARY SNAP
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adolescent Gynecology
Authors: John Huffman
Journal: JAMA (1967)

The reader who picks up this little book with the expectation of finding 11 well-written papers delivered at a symposium on adolescent girls and their problems will be well pleased. He will be disappointed, however, if he expects to find a comprehensive and practical approach to the diagnosis and treatment of gynecological disorders in adolescents. The symposium began with three esoteric dissertations on the reproductive endocrinology of adolescence, the biochemistry of steroids and hormones, and the identification of the sex hormones. The conclusions that the adolescent attains the peak of her reproductive efficiency in a gradual manner, that it takes a decade to go from childhood to maturity, that there may be some kind of aberration in the hypothalamic regulation of the gonadotropins that secondarily produces polycystic ovaries, and that we may well distrust the figures provided by clinical endocrine laboratories, are supported by a mass of scientific evidence. This
BOOK REVIEWS
Journal: Circulation (1950)

9 charts.$2.50.This work is reprinted from Oxford Loose-Leaf Medicine.In 86 pages, the etiology, pathology, symptoms, signs, differential diagnosis and treat- ment of hypertension are surveyed.Ayman does not believe that experimental renal hypertension has any similarity to essential hyper- tension, and therefore feels that anv consideration of it is beside the point.He stoutly maintains that essential hypertension is an hereditary disease, the mechanism of which is wholly unknown.This view- point is one which, for a variety of reasons, is not completely satisfying.It is, however, proper to emphasize that no proof has been offered that the sole cause of essential hypertension is renal.Especially to be commended is the stress put on the need for adequate control periods in evaluation of experimental treatment.The author was largely responsible for the interesting study of blood pres- sure taken by patients themselves in the home, demonstrating that the average blood pressure level under this circumstance is usually well below the level found in the physician's office.He is also identi- fied with a remarkable demonstration of the "effec- tiveness" of placebos.A third facet of especial interest is identification of the symptomology of ar- terial hypertension with that of psychoneurosis.This accounts for the fact that symptoms are im- proved or cured by such a variety of "treatments," several hundred of which have been suggested or practised in the past fifty years.This book is welcomed as a substantial addition to the literature on hypertension for the more than usually discerning and industrious physician, and is heartily recommended.
SINUS PERICRANII
Authors: J. E. Engstad
Journal: JAMA (1926)

A. A., a woman, aged 20, weighing 71 kg., of florid complexion and enjoying excellent health, with negative family history, had a marked protuberance a little to the left of the outer elevation of the left frontal bone, almost circular in outline and about 1 cm. in diameter, which increased in size if she bent her head downward or when in a prone position. No pulsations were felt. To the tactile sense it felt soft and doughy, akin to a soft flattened cyst or fatty tumor. It had been observed for a number of years but had not shown any tendency to enlargement up to within six months, when its growth became quite rapid. It was not painful to manipulation nor did the young woman complain of any inconvenience from the growth except its disfiguring effect. The diagnosis was sinus pericranii or incipient cerebral hernia. Under local anesthesia a Greek cross incision was made through the integument, when a large mass of varicose veins was encountered.
Pharmacotherapy and Behavioral Intervention for Alcohol Dependence
Authors: Jeffrey M. Jonas, Sylvie Chabac
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surprise, surprise
Authors: Daniel C. Dennett
Journal: Behavioral and Brain Sciences (2001)

The authors show that some long-standing confusions and problems can be avoided by thinking of perception in terms of sensorimotor contingencies, a close kin to my heterophenomenological approach (Dennett 1991). However, their claim that subjects do not have any commitments about the resolution of their visual fields is belied by the surprise routinely expressed by subjects when this is demonstrated to them.