tbuckley/cabot-search huggingface dataset:
INTERESTING CASES OF PERINEAL SECTION, WITH REMARKS.
Authors: G. FRANK LYDSTON
Journal: JAMA (1896)

<h3>Case 50: Deep Stricture of Large Caliber with Irritable Bladder.</h3> —A medical man, 36 years of age, consulted me regarding an intractable gleet, with chronic cystitis and a small perineal fistula. I found the bladder in fairly good condition, the so-called chronic cystitis being a chronic follicular prostatitis (so-called posterior urethritis) from old gonorrheal infection. The urethra would admit a 28 French sound, but there was marked deep spasm. With a 15 bulb (bulb exploratrice of Guyon) a distinct large calibered linear stricture was found at the bulbo-membranous junction. The condition of this case and the indications seemed perfectly plain. Infection from the imperfectly drained canal behind the stricture, explained the chronicity of the prostatic trouble, and the occurrence of a small peri-urethral abscess which had undoubtedly preceded the fistula. The reflex irritation produced by the stricture was sufficient to account for the spasmodic contraction of the true sphincter vesicæ
Obstetrics for Nurses.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RICHARD LOWER (1631-1691) PHYSIOLOGIC CARDIOLOGIST
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Trials
Authors: Charles Moldow
Journal: Annals of Internal Medicine (2002)

Medical Writings: Book Notes3 September 2002Clinical TrialsCharles Moldow, MDCharles Moldow, MDUniversity of Minnesota Medical School, Minneapolis, Minnesota.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-5_Part_1-200209030-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Duley L and Farrell B, eds. 133 pages. London: BMJ Books; 2002. $15.95. ISBN 0727915991. Order at www.bmjbooks.com.Field of medicine: Clinical trials.Format: Softcover book.Audience: Personnel recruited to work in clinical trials research, research fellows, residents, and medical and health professional students.Purpose: To review clinical trials methodology, covering issues from trial conception, design, purpose, implementation, and analysis, and to discuss the challenges that face clinical trials research.Content: This is a multiauthor publication of presentations given at an Oxford seminar in 2000. The early chapters deal with history and reasons for the development of clinical trials, with ... Author, Article, and Disclosure InformationAffiliations: University of Minnesota Medical School, Minneapolis, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 September 2002Volume 137, Issue 5_Part_1Page: 380KeywordsClinical trialsResearch and reporting methodsSafetySoftware toolsTouch ePublished: 3 September 2002 Issue Published: 3 September 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Human Skeleton Showing Principal Arterial Circulation (First Aid Pressure Point Chart)
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amelioration of Bleomycin-Induced Lung Fibrosis in Hamsters by Dietary Supplementation with Taurine and Niacin: Biochemical Mechanisms
Authors: Shri N. Giri, Robert Blaisdell, Robert B. Rucker, Qingjian Wang, Dallas M. Hyde
Journal: Environmental Health Perspectives (1994)

Interstitial pulmonary fibrosis induced by intratracheal instillation of bleomycin (BL) involves an excess production of reactive oxygen species, unavailability of adequate levels of NAD and ATP to repair the injured pulmonary epithelium, and an overexuberant lung collagen reactivity followed by deposition of highly cross-linked mature collagen fibrils resistant to enzymatic degradation.In the present study, we have demonstrated that dietary supplementation with taurine and niacin offered almost complete protection against the lung fibrosis in a multidose BL hamster model.The mechanisms for the protective effect of taurine and niacin are multifaceted.These include the ability of taurine to scavenge HOCI and stabilize the biomembrane; niacin's ability to replenish the BL-induced depletion of NAD and ATP; and the combined effect of taurine and niacin to suppress all aspects of BL-induced increases in the lung collagen reactivity, a hallmark of interstitial pulmonary fibrosis.It was concluded from the data presented at this Conference that the combined treatment with taurine and niacin, which offers a multipronged approach, will have great therapeutic potential in the intervention of the development of chemically induced interstitial lung fibrosis in animals and humans.
Cholescintigraphy in the evaluation of jaundice
Authors: S. J. Morayati
Journal: JAMA (1990)

<h3>To the Editor.—</h3> I read with interest the recent article on the clinical evaluation of jaundice by Dr Frank and members of the Patient Care Committee of the American Gastroenterological Association.<sup>1</sup>The authors reviewed accurately the usefulness of noninvasive studies, including ultrasonography and computed tomographic scan, in the assessment of jaundice. However, the value of cholescintigraphy as an adjunct noninvasive study and in selected cases as the modality of choice in screening patients was overlooked. Ultrasound is poor at detecting common bile duct stones; not all obstructed ducts are dilated and not all dilated ducts are functionally obstructed, especially after cholecystectomy,<sup>2,3</sup>and therefore cholescintigraphy can play a major role in the diagnosis of obstructed jaundice. Its overall accuracy is reported to be about 96% to 97%.<sup>4</sup>Cholescintigraphy has a distinct advantage in patients in whom choledocholithiasis is considered to be the most likely cause (eg, acute
Evidence That a Hemoglobin Adduct Used for Dosimetry of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone Is a Carboxylic Ester
Authors: Steven G. Carmella, Shashi S. Kagan, Stephen S. Hecht
Journal: Environmental Health Perspectives (1993)

Hemoglobin adducts of the carcinogenic tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) release 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) upon mild base or acid hydrolysis. HPB has been detected in hydrolysates of hemoglobin from smokers and snuff dippers and has been proposed as a dosimeter of exposure to and metabolic activation of NNK in people exposed to tobacco products. In this study, labeling experiments were carried out with [18O]NaOH that provide strong evidence that the globin adduct that releases HPB upon hydrolysis is a carboxylic ester. Globin was isolated from rats treated with [5-3H]NNK. This globin was reacted with NaCNBH3, followed by hydrolysis at room temperature with 0.2 N NaOH. Analysis of the products demonstrated the presence of 4-hydroxy-1-(3-pyridyl)-1-butanol, but not HPB. These results demonstrate that the adduct in globin has a free carbonyl group and is not a Schiff base. This sequence of reactions was then carried out with [18O]NaOH under conditions that were shown to result in incorporation of 18O if nucleophilic displacement at C-4 had occurred. Analysis by GC-MS of the 4-hydroxy-1-(3-pyridyl)-1-butanol formed in this experiment demonstrated that there was no incorporation of 18O. These results are consistent only with the hydrolysis of an ester by a BAC2 mechanism. Therefore, the adduct releasing HPB upon mild base hydrolysis must be a 4-(3-pyridyl)-4-oxobutyl ester of aspartate, glutamate, or a terminal carboxylate.(ABSTRACT TRUNCATED AT 250 WORDS)
“Global strategy for asthma management and prevention: GINA executive summary.” E.D. Bateman, S.S. Hurd, P.J. Barnes, J. Bousquet, J.M. Drazen, J.M. FitzGerald, P. Gibson, K. Ohta, P. O'Byrne, S.E. Pedersen, E. Pizzichini, S.D. Sullivan, S.E. Wenzel and H.J. Zar. <i>Eur Respir J</i> 2008; 31: 143–178.
Journal: European Respiratory Journal (2018)
Stereoskopischer Atlas der äusseren Erkrankungen des Auges nach farbigen Photographien für Studium und ärztliche Fortbildung mit begleitendem Text.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic and therapeutic technology assessment. 24-hour ambulatory EEG monitoring
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toxic Effects in C57B1/6 and DBA/2 Mice Following Consumption of Halogenated Aromatic Hydrocarbon-Contaminated Great Lakes Coho Salmon (Oncorhynchus kisutch Walbaum)
Authors: Glenn B. Cleland, John F. Leatherland, Ronald A. Sonstegard
Journal: Environmental Health Perspectives (1987)

Diets containing coho salmon (Oncorhynchus kisutch Walbaum) from the Pacific Ocean or from Lakes Erie, Michigan, and Ontario [containing a gradation from low to high of halogenated aromatic hydrocarbons, (HAHs)] were fed to C57B1/6 and DBA/2 mice. Following a 4-month dietary exposure to Lake Ontario salmon, both strains of mice demonstrated hepatomegaly. The ethoxyresorufin-O-deethylase (ERR) enzyme levels were elevated in livers of C57B1/6 mice fed diets of salmon from all of the Great Lakes studied, with exceptionally high levels detected in C57B1/6 mice fed Lake Ontario salmon. Induction of ERR enzyme levels was detected in DBA/2 mice only following dietary exposure to Lake Ontario salmon. Serum levels of L-thyroxine (T4) and triiodo-L-thryonine (T3) were suppressed in C57B1/6 mice following consumption of Lake Ontario coho salmon, but T3 and T4 levels remained unchanged in DBA/2 mice. In general, pathobiological effects correlated with both dietary HAH exposure level and Ah receptor status.
Gut ischaemia.
Authors: U Haglund
Journal: Gut (1994)

Intestinal mucosal injury that results from local ischaemia can be detected by early increases in gut permeability, followed by later morphological, histological, and biochemical abnormalities. Local adaptive mechanisms (for example increased oxygen extraction) can cope with reductions in blood flow of up to 50%, as may occur during episodes of septic shock or cardiac tamponade. Why then does hypoxic injury develop? The peculiar vascular anatomy of the villi allows for oxygen short circuiting to occur at their base, when blood flow is low. Although overall oxygen extraction efficiency may be high, regional hypoxia at the villus tip may, paradoxically occur. The severity of reperfusion injury depends on the duration of preceding hypoxia. Free radical generation through the hypoxanthine xanthine oxidase system is important in mediating cellular damage. In addition, luminal aggressive factors (for example, pancreatic proteases) may cause mucosal damage, as suggested by earlier studies. More recent studies in pigs suggests that pancreatic duct ligation merely delays, but does not prevent development of gut reperfusion injury. Enteral nutrition should benefit patients with the ischaemic intestine because in comparison with total parental nutrition, it stimulates regional blood flow, and attenuates mucosal injury. There are no randomised trials to verify this, but use of tonometry to monitor local ischaemia may help resolve the issue.
Elemental Mercury Releases Attributed to Antiques—New York, 2000-2006
Journal: JAMA (2007)

Metallic (i.e., elemental) mercury, a heavy, silvery odorless liquid, is in common household products such as thermostats and thermometers. Lesser-known household sources of elemental mercury include certain antique or vintage items such as clocks, barometers, mirrors, and lamps. Over time, the mercury in these items can leak, particularly as seals age or when the items are damaged, dropped, or moved improperly. Vacuuming a mercury spill or vaporization from spill-contaminated surfaces such as carpets, floors, furniture, mops, or brooms can increase levels of mercury in the air, especially in enclosed spaces. Environmental sampling conducted after releases of elemental mercury have indicated substantial air concentrations that were associated with increases in blood and urine mercury levels among exposed persons. In 1990, the Agency for Toxic Substances and Disease Registry (ATSDR) created the Hazardous Substances Emergency Events Surveillance (HSEES) system, a multistate health department surveillance system designed to help reduce morbidity and mortality associated with hazardous substance events. This report describes antique-related mercury releases reported to HSEES, all of which occurred in New York state during 2000-2006. Although none of these spills resulted in symptoms or acute health effects, they required remediation to prevent future mercury exposure. The findings underscore the need for caution when handling antiques containing elemental mercury and the need for proper remediation of spills.
Abstract 3051: Long Term Results Of Open Endovascular Repair For Aortic Dissections
Authors: Kazuo Shimamura, Toru Kuratani, Goro Mastumiya, Yoshiyuki Shirakawa, Mugiho Takeuchi, Masaaki Kato, Hiroshi Takano, Yoshiki Sawa
Journal: Circulation (2007)

Background . Complete resection of the intimal tear in aortic arch is one of the most complicated tasks in the treatment of aortic dissections. We introduced open stent grafting technique to complete this task with technical easiness. In this study we evaluated the long term efficacy of this procedure from our 12 years experience. Patients and Method. Form January 1994 to December 2004, 59 aortic dissections with intimal tear in aortic arch or proximal descending aorta were operated with open stent grafting technique (age 61.7yrs, 41 type A and 18 type B). Thirty three (55.9%) were in emergency status. All these cases were morphologically excluded from the indication of transluminal endovascular repair. Under deep hypothermic circulatory arrest with antegrade cerebral perfusion, the hybrid prosthesis was inserted into descending aorta through the transected proximal aortic arch in order to achieve intimal tear exclusion. Results. Complete exclusion of the aortic arch intimal tear was achieved in all cases. Operative mortality within 30 days was 3.4%. Major postoperative complications included 4(6.8%) cerebral infarctions, 2 (3.4%) paraplegia, 2 (3.4%) transient paraparesis. Median follow up was 71.2 months (maximum 153 months). One patient (1.7%) showed type I endoleak from the distal end. In 6 patients (10.2%) additional endovascular repair for other thoracic lesions were performed, and only one case with Marfan syndrome required open surgical repair for thoracoabdominal aorta because of expansion of the remaining thoracic dissection. CT scan showed shrinkage of the false channel in 78.6% of the patients. There were no rupture of the remaining dissected aorta and the freedom from aortic related death was 94.7%, 94.7%, and 88.8% at 1,5, and 8 years respectively. Conclusion. This study suggested that open stent grafting is a safe and effective technique with good long-term results. This procedure could be an alternative and standard method to repair aortic dissections with aortic arch intimal tear.
Removal by traction of incarcerated transvenous pacemaker electrode
Authors: A. M. Bilgutay
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Cardiac pacing by transvenous electrode has extended this therapeutic modality to those too ill for thoracotomy. Thus, it is often temporarily used in rhythm disturbances due to myocardial infarction. The present development of demand impulse generators, which avoid the risk of competitive stimulation with resultant ventricular arrhythmia and fibrillation, will greatly increase the usefulness of the transvenous electrode in the management of myocardial infarction. Transvenous pacing has been beset with many complications. While improvement of impulse generators may reduce their related complications materially, the problems of the transvenous electrodes remain. These complications related to transvenous electrodes have been reported in the literature:<sup>1-7</sup> Arrhythmias during insertion Bleeding Infection Thrombophlebitis Wound sepsis Subacute bacterial endocarditis Air embolization Phrenic stimulation Fracture of electrode Erosion of the electrode through the skin Perforation of the right ventricle Displacement of the electrode with loss of pacing. The transvenous electrode is quickly incorporated into
Campaign alerts physicians to identify, assist victims of domestic violence
Authors: C. Raymond
Journal: JAMA (1989)

IT'S ONE OF THE MOST underreported crimes in the United States. It claims a victim every 15 seconds. Its victims are often ashamed to report it. It is not rape. The crime is wife beating, and, according to Surgeon General C. Everett Koop, MD, "it's an overwhelming moral, economic, and public health burden that our society can no longer bear. No man has a license to beat... and get away with it, and no woman is obliged to accept a beating... and suffer because of it." <h3>Enlisting ACOG's Aid</h3> Koop's ringing words kicked off a 1989 campaign to improve awareness of the problem among the physicians who often are a woman's primary care provider—obstetricians and gynecologists. All 27 000 members of the American College of Obstetricians and Gynecologists (ACOG) will be receiving a technical bulletin that describes the nature of domestic violence and how to identify and assist its victims