tbuckley/cabot-search huggingface dataset:
Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a
Authors: H Okamoto
Journal: Hepatology (1994)

Three chimpanzees persistently infected with hepatitis C virus of genotype II/1b were challenged with hepatitis C virus of genotype III/2a and 6 wk later with hepatitis C virus of genotype I/1a. They were tested for titers of total and genotype-specific hepatitis C virus RNA, as well as for serum transaminase levels, until 52 wk after the first challenge. One chimpanzee (CH489) with intermittent low hepatitis C virus RNA titers of genotype II/1b in serum was superinfected with hepatitis C virus of genotype III/2a between wk 1 and 7 after the challenge; superinfection was accompanied by fluctuating high transaminase levels. Later, the animal was superinfected with hepatitis C virus of genotype I/1a. Superinfection was accompanied by persistently high transaminase levels immediately after the challenge. Hepatitis C virus of genotype I/1a persisted, whereas hepatitis C virus of genotype II/1b was undetectable 22 wk after the challenge and thereafter. In another chimpanzee (CH353) with intermittent low hepatitis C virus RNA titers of genotype II/1b, hepatitis C virus of genotype III/2a induced fluctuating high levels of serum transaminases without revealing itself in serum. Then, HCV of genotype I/1a superinfected her, induced persistently high transaminase levels and took over HCV of genotype II/1b at 22 wk after the challenge and thereafter. The third chimpanzee (CH451) with persistently high HCV RNA titers of genotype II/1b did not reveal HCV RNA of genotype III/2a in serum after the challenge, although transaminases sharply increased. Low-titered HCV RNA of genotype I/1a was detected at 18 wk after the challenge. He continued to have elevated transaminase levels and high-titered HCV RNA of genotype II/1b throughout the observation period. These results indicate superinfection with HCV of different genotypes in chimpanzees, newly introduced HCV replacing or being expelled by the predecessor HCV with each infection inducing an episode of liver injury. (Hepatology 1994;20:1131–1136).
Software
Authors: Alan T. Lefor
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AN INSTANTANEOUS BRILLIANT ILLUMINATOR FOR SURGEONS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MICHIGAN BOARD OF REGISTRATION AND LOW-GRADE MEDICAL COLLEGES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Association" Misused
Authors: A.M. PARFITT
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 October 1978"Association" MisusedA.M. PARFITT, M.D.A.M. PARFITT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-4-579_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent discussion on hypertrophic subaortic stenosis and hypercalcemia is a good example of the confusion generated by misuse of the word "association" in medical writing. In the technical statistical sense association can be manifested only in a population, not in an individual case. To denote the presence in a single patient of two diseases it is better to use the term "coexistence" or "concurrence." Several instances of concurrence of hypertrophic subaortic stenosis and hypercalcemia were reported (1, 2), for which a reasonable physiologic explanation was given (3). As yet there is no evidence for an association...References1. MCFARLANDSTEFADOUROSABDULLAMCFARLAND KMAD: Hypercalcemia and idiopathic hypertrophic subaortic stenosis. Ann Intern Med 88:57-58, 1978 LinkGoogle Scholar2. DIXONGROSS JL: Hypertrophic subaortic stenosis and hypercalcemia. Ann Intern Med 88:576, 1978 LinkGoogle Scholar3. MALCOLM I: Hypertrohpic subaortic stenosis and hypercalcemia. Ann Intern Med 88:576, 1978 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByScale Formation and Prevention 1 October 1978Volume 89, Issue 4Page: 579-580KeywordsHypercalcemiaStenosis Issue Published: 1 October 1978 PDF DownloadLoading ...
Leads from the MMWR. Trends in years of potential life lost due to infant mortality and perinatal conditions, 1980-1983 and 1984-1985
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for prostate cancer
Authors: W. J. Catalona
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The article by Dr Krahn and colleagues<sup>1</sup>on screening for prostate cancer is misleading and cannot be applied to the average prostate cancer patient. The study perpetuates erroneous assumptions, questionable utilities, and flawed data on rates of metastases, mortality, and treatment complications used in decision analytic studies of prostate cancer.<sup>2</sup>Many of the data are outdated and precede the recent use of prostate-specific antigen (PSA) for screening, thus underestimating the sensitivity of this test. Recent studies also have shown a stage shift from 35% curable cancer in unscreened men to 70% to 85% curable cancer in screened populations.<sup>3</sup> By basing the analysis solely on the study by Johansson et al,<sup>4</sup>Krahn et al substantially underestimate the lethal potential of prostate cancer. The population in the study by Johansson et al contained a disproportionate number of elderly men with less aggressive cancers. These men
BOOK REVIEWS
Authors: LAWRENCE LEICHMAN
Journal: JNCI Journal of the National Cancer Institute (1993)

BOOK REVIEWS Get access LAWRENCE LEICHMAN LAWRENCE LEICHMAN Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 20, 20 October 1993, Pages 1691–1692, https://doi.org/10.1093/jnci/85.20.1691-a Published: 20 October 1993
Prevention and control of hypertension by nutritional-hygienic means. Long-term experience of the Chicago Coronary Prevention Evaluation Program
Authors: J. Stamler
Journal: JAMA (1980)

In the Chicago Coronary Prevention Evaluation Program (CPEP), 115 men had definite mild hypertension at entry; another 101 men had high-normal diastolic blood pressure (BP). The nutritional-hygienic nonpharmacologic CPEP regimen achieved years-long moderate weight loss, slowing of pulse rate, and reduction in serum cholesterol levels. Sustained falls in BP were recorded—about 10/13 mm Hg for hypertensive men, resulting in long-term normalization of BP, and about 7/4 mm Hg for men with high-normal BP at entry. Change in weight and change in BP were significantly correlated. Long-term improvements in eating and exercise habits yielding moderate sustained weight loss are apparently useful in preventing high BP in hypertension-prone persons and in controlling established "mild" hypertension. (<i>JAMA</i>243:1819-1823, 1980)
A NUTRITIONAL OUTLOOK
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Folate and Mecobalamin on Hip Fractures in Patients With Stroke: A Randomized Controlled Trial—Correction
Authors: Michael Marmot, I Gough, Yoshihiro Sato, Yoshiaki Honda, Jun Iwamoto, Tomohiro Kanoko
Journal: JAMA (2006)

In Reply: Dr Clark and Ms Lissel caution against arguing for a single mechanism in understanding the link between poverty and ill health.I agree.First, as my Commentary points out, we are not trying simply to understand why people in poverty are in poor health, but why health follows a social gradient through the whole of society.Any appeal to a single mechanism of poverty will not do justice to the evidence.Second, I do not argue for the primacy of "social status" as if it were one single mechanism.I state that relative differences in status translate into absolute differences in life chances.In considering these life chances, we need to focus on the circumstances in which people live and work.Clark and Lissel's argument for complexity and for considering "influential causal mechanisms [that] defy quantification" could be taken as a counsel of despair for the researcher and solace for the reluctant policy maker.If it is all very complex and some of the mechanisms cannot be measured, a researcher cannot reach conclusions and a policy maker can, therefore, legitimately throw up her hands.In an effort to reduce the complexity to manageable proportions, I point to fundamental human needs of autonomy and full social participation. 1 These will be affected by a complex array of influences.The solutions will not be simplistic or even simple.Indeed, I argue not for action on one single mechanism, but suggest that "reductions in the gradient in health and disease will require action across a broad front, starting with women of childbearing age, early child development, education, skills training, better working and living conditions, and support for older individuals."
Peripheral Circulation
Authors: William H. Wehrmacher
Journal: JAMA (1978)

Traditional concepts of the peripheral circulatory function now have been radically reshaped. Paul C. Johnson, professor of physiology at the University of Arizona in Tucson, has asked 14 contributors to this currently rapidly evolving field to "synthesize new findings with existing knowledge" rather than simply to present up-to-the-moment information. As a guide to the current thinking in rational perspective, physicians who wish to keep abreast with these new developments and to integrate them with their own current perspective of the peripheral circulation will find this book useful to avoid the necessity of reviewing the extensive publications that have been appearing recently. The first five chapters examine basic properties of the system common to all organs. Dr Johnson points out that the system distributes a cardiac output of about 8,400 liters/day to tissues where about 20 liters are filtered into the interstitium and must be returned by lymphatic and venular systems
Erratum
Authors: Irving Kushner, John Volanakis
Journal: Environmental Health Perspectives (1981)

The New York Academy of Sciences is sponsoring a conference on C-reactive protein and the plasma protein response to tissue injury on September 21-23, 1981 at the Barbizon-Plaza Hotel in New York City.C-reactive protein (CRP) is a plasma protein of hepatic origin whose rate of synthesis increases markedly following tissue injury and inflammation.A number of plasma proteins, the acute phase proteins, behave in a similar manner.Research on CRP and other acute phase proteins is progressing at an increasingly rapid pace.This conference will bring together investigators from a variety of fields to discuss the regulation of biosynthesis, structure, binding specificities, biologic properties, relevance to disease and biologic significance of CRP and related proteins.
Cataractous Families.
Authors: G. N. Brazeau
Journal: JAMA (1904)

Fond du Lac, Wis., July 14, 1904. <h3>To the Editor:</h3> —At the suggestion of Dr. John L. Dickey I wish to add another case to his as an instance of the hereditary tendency to cataracts. While I have not sufficient data at hand to thoroughly convince me that heredity should be classed among the causes of cataracts, nevertheless my experience has been such as to make me think of it as a possible cause. I am pleased to learn that some one is investigating the subject and as evidence I report a case wherein the mother, a son, a daughter and a grandson are all afflicted with partial cataracts. The mother is 64, the son and daughter respectively 36 and 32, and the grandson 10.
"Brain attack"
Authors: S Macdonald, A Dixit, M G Wyatt
Journal: BMJ (2009)

A 57 year old, right handed man was seen as an emergency after an episode of “flinging” movements of his right arm and leg and slurred speech. He had no visual or sensory symptoms. Examination showed mild right pronator drift, and dysarthria. His symptoms resolved within 45 minutes. Blood pressure was 135/75 mm Hg and blood sugar was normal. Electrocardiography confirmed sinus rhythm, and computed tomography of the brain was reported as showing a well defined left cerebellar infarct. Figure 1⇓ shows two images of the origin of the left internal carotid artery. ### Short answers
Manuscripts Approved for JNCI, October 1 to November 1, 1965
Journal: JNCI Journal of the National Cancer Institute (1965)

Journal Article Manuscripts Approved for JNCI, October 1 to November 1, 1965 Get access JNCI: Journal of the National Cancer Institute, Volume 35, Issue 6, December 1965, Pages 1073–1074, https://doi.org/10.1093/jnci/35.6.1073-a Published: 01 December 1965
PURULENT BRAIN DEPOSITS, AND PHLEBITIS AND THROMBOSIS OF THE CEREBRAL VEINS AND SINUSES FOLLOWING EAR DISEASE.
Authors: FRANK ALLPORT
Journal: JAMA (1892)

(<i>Continued from page 604</i>.) <i>Case 135</i>.—Extract from Treatise on the Ear, by Roosa. Reported by Gull and Sutton. Male, age eight. Left ear. Chronic otorrhœa; vomiting; convulsions; paralysis of left upper eye-lid; limbs all weak; pain in left ear; dull; drowsy; semi-comatose; coma. Death. <i>Autopsy</i>.—Abscess in left cerebral hemisphere. <i>Case 136</i>.—Extract from Treatise on the Ear, by Roosa. Reported by Gull and Sutton. Female, age twenty-six. Right ear. Purulent otorrhœa; delirium; episthotonos; coma. Death. <i>Autopsy</i>.—Abscess in under surface of middle cerebral lobe. <i>Case 137</i>.—Extract from Treatise on the Ear, by Roosa. Reported by Gull and Sutton. Female, age fifty-one. Left ear. Purulent otorrhœa; cough; pain in limbs; pulse quick; convulsions; coma. Death. <i>Autopsy</i>.—Abscess in left cerebral hemisphere. <i>Case 138</i>.—Extract from Treatise on the Ear, by Roosa. Reported by Gull and Sutton. Female, age twenty-three. Left ear. Epilepsy; convulsions; pain in head; fever; intense agony; convulsions. Death. <i>Autopsy</i>.—Abscess. Coagulum of fibrin
Ectopic Gestation.
Authors: B. Becker
Journal: JAMA (1895)

Toledo, Ohio, Nov. 1, 1895. <h3>To the Editor:</h3> —Dr. D. von Ott at Petersburg, in Russia, has recently published his clinical and experimental observations concerning ectopic pregnancy. Of the most importance for the practitioner I consider his thoughts regarding therapeutics, and therefore I wish to lay out his conclusions. Wherever the diagnosis of an uninterrupted extra-uterine gestation is positively made, the extirpation of the ovary by laparotomy is indicated. If the patient has reached the second half of pregnancy, we may, if the mother demands it, delay operation until the fetus can be considered able to live, although great dangers are connected with this risk. If pregnancy is advanced to first and second months only, and the further development now stopped, that means if the fetus is dead, we may restrict our therapeutic action to close observation of the patient. If gestation is farther advanced and the fetus dead, extirpative
Is there still room for therapeutic drug monitoring of linezolid in patients with tuberculosis?
Authors: Dario Cattaneo, Cristina Gervasoni, Emilio Clementi
Journal: European Respiratory Journal (2016)

Bolhuis et al. [1] recently reported the results of a retrospective study aimed at investigating linezolid safety and tolerability in relation to linezolid exposure in 58 patients with multidrug-resistant tuberculosis. As one of the main findings, they observed no significant differences in linezolid area under the curve from 0 to 24 h (AUC0–24) or linezolid trough concentrations between patients experiencing or not experiencing drug-related adverse events. These findings apparently argue against a potential role of therapeutic drug monitoring (TDM) as a feasible tool to optimise linezolid dosing in the day-by-day management of patients with tuberculosis. A study of linezolid TDM in tuberculosis is at odds with studies in Gram-positive bacterial infections <http://ow.ly/WXKQY>
Influence of the Watch and Wait Strategy on the Clinical Outcome in Patients with Follicular Lymphoma in the Rituximab Era
Authors: Sayako Yuda, Dai Maruyama, Akiko Miyagi Maeshima, Shin-ichi Makita, Hideaki Kitahara, Miyamoto Ken-ichi, Suguru Fukuhara, Wataru Munakata, Tatsuya Suzuki, Yukio Kobayashi, Kinuko Tajima, Hirokazu Taniguchi, Kensei Tobinai
Journal: Blood (2014)