INSULIN RESISTANCE
Authors: A R AXELROD, S LOBE
Journal: Annals of Internal Medicine (1947)

Article1 October 1947INSULIN RESISTANCEARNOLD R. AXELROD, M.D., SIDNEY LOBE, M.D., JAMES M. ORTEN, Ph.D., GORDON B. MYERS, M.D., F.A.C.P.ARNOLD R. AXELROD, M.D.Search for more papers by this author, SIDNEY LOBE, M.D.Search for more papers by this author, JAMES M. ORTEN, Ph.D.Search for more papers by this author, GORDON B. MYERS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-4-555 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well known that marked variations in sensitivity to insulin are found among diabetics, even in the absence of complications. This has led to attempts at classification into one of three categories, namely: (a) insulin sensitive, (b) insensitive, and (c) resistant. Insulin resistance is rare but is readily distinguished from the other two categories. According to the definition of Martin, Martin, Lyster and Strouse,1insulin resistance is present when doses of 200 units or more per day fail to reduce the blood sugar in non-acidotic patients during 48 hours' observation. This was based upon Root's calculation that depancreatized man...Bibliography1. MARTINMARTINLYSTERSTROUSE WPHERWS: Insulin resistance, critical survey of the literature with the report of a case, Jr. Clin. Endocrinol., 1941, i, 387-397. CrossrefGoogle Scholar2. GOLDNERCLARK MGDE: The insulin requirement of man after total pancreatectomy, Jr. Clin. Endocrinol., 1944, iv, 194-197. CrossrefGoogle Scholar3. BRUNSCHWIGRICKETTSBIGELOW AHTRR: Total pancreatectomy, total gastrectomy, total duodenectomy, splenectomy, left adrenalectomy and omentectomy in a diabetic patient, recovery, Surg., Gynec. and Obst., 1945, lxxx, 252-256. Google Scholar4. LOZINSKIFROHLICH ELI: Resistance to insulin, Canad. Med. Assoc. Jr., 1942, xlvi, 62-65. Google Scholar5. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExacerbation of Diabetes Mellitus by Antibodies to Exogenous InsulinInsulin-Binding Antibodies of Serum and Insulin ResistanceSpontaneous disappearance of insulin-resistant diabetes mellitus in a patient with a collagen diseaseChronic insulin resistanceNeue Erkenntnisse in der Behandlung der chronischen Insulinresistenz und experimentelle Untersuchungen zu ihrer GeneseHumoral insulin antagonism associated with diabetic acidosisObservations on the Relation Between Insulin Coma Dosage and Prognosis in SchizophreniaDiabetic coma 1 October 1947Volume 27, Issue 4Page: 555-574KeywordsBlood sugarHospital medicineInsulinInsulin resistance ePublished: 1 December 2008 Issue Published: 1 October 1947 PDF downloadLoading ...