tbuckley/cabot-search huggingface dataset:
Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies
Authors: S Moteki
Journal: Hepatology (1996)

The detection of antimitochondrial autoantibodies (AMAs) is critical in the diagnosis of primary biliary cirrhosis (PBC). However, conventional laboratory assays to detect AMA are dependent on the time-consuming method of immunofluorescence microscopy, a method often plagued by problems of nonspecificity. AMAs react against mitochondrial autoantigens including the E2 components of the pyruvate dehydrogenase complex (PDC-E2), the branched-chain 2-oxo-acid dehydrogenase complex (BCOADC-E2), and the 2-oxo-glutarate dehydrogenase complex (OGDC-E2). Interestingly, the immunodominant epitopes of PDC-E2, BCOADC-E2, and OGDC-E2 are all conformational lipoate binding sites, but antibodies against them do not cross-react. Although 80% to 90% of sera from patients with PBC react to PDC-E2, approximately 10% patients with PBC react only to BCOADC-E2 and/or OGDC-E2. We have taken advantage of our epitope-mapping studies of the E2 components of PDC, BCOADC, and OGDC, and constructed a “designer” hybrid clone, designated as pML-MIT3, that coexpresses the immunodominant epitopes within the three distinct lipoyl domains. We examined a total of 321 sera, including 186 sera from patients with PBC, to test the immunoreactivity of pMIT3. Of 186 sera from patients with PBC, 152 sera (81.7%) reacted with recombinant fusion protein of PDC-E2, whereas 171 sera (91.9%) showed positive reactivities when probed by immunoblotting against the recombinant fusion protein expressed from the pML-MIT3 clone. Of 34 PBC sera that did not react with recombinant PDC-E2, 18 sera contained BCOADC-E2-specific AMA and 1 serum possessed only OGDC-E2-specific AMA. We also developed an enzyme-linked immunosorbent assay (ELISA), using affinity-purified recombinant fusion protein of pML-MIT3 clone as the antigen source, to quantify specific AMAs in patients with PBC. None of the 135 control sera from patients with primary sclerosing cholangitis (PSC), chronic autoimmune hepatitis (CAH), systemic lupus erythematosus (SLE), or healthy volunteers showed significant reactivity against pML-MIT3 recombinant fusion protein in the ELISA assay. Our results indicate that an ELISA using recombinant, cloned autoantigen of pML-MIT3 is a powerful and very specific method for the detection of AMA.
SYPHILIS OF THE KIDNEY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stem cells: science, policy, and ethics
Authors: G. D. Fischbach
Journal: Journal of Clinical Investigation (2004)

The definition of "totipotent" was incorrectly identified as "Cell committed to a specific lineage that is capable of giving rise to all types of differentiated cells and tissues, including extraembryonic tissues."The correct definition is "Cell not committed to a specific lineage that is capable of giving rise to all types of differentiated cells and tissues, including extraembryonic tissues."
Permanent implantation of the Jarvik-7 total artificial heart: a clinical perspective
Authors: G. M. Lawrie
Journal: JAMA (1988)

In this issue ofTHE JOURNAL, DeVries<sup>1</sup>reports the clinical courses of four patients in whom Jarvik-7 total artificial heart (TAH) prostheses were implanted as permanent cardiac substitutes. All four patients subsequently suffered serious complications; despite these, three patients achieved survival with the TAH for intervals of 112, 488, and 620 days. The Jarvik-7 prosthesis is a direct descendant of the early series of pneumatically driven TAH prostheses developed by Willem Kolff, MD, and colleagues working first at The Cleveland Clinic and later at the University of Utah.<sup>2</sup>In February 1963, Michael E. DeBakey, MD, proposed that the federal government support an organized program to develop a TAH.<sup>3</sup>Established at the National Institutes of Health in 1964, the Artificial Heart Program had as its goals the development of a broad spectrum of devices for short-term circulatory and longterm ventricular assistance as well as the development of TAH
New York City.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone marrow necrosis from miliary tuberculosis
Authors: H. Katzen
Journal: JAMA (1980)

ALTHOUGH anemia and leukopenia are not unusual with tuberculosis, pancytopenia is rare.<sup>1,2</sup>When pancytopenia does occur, it is usually due to an underlying primary hematologic disorder and is almost always fatal.<sup>3,4</sup> <h3>Report of a Case</h3> A 36-year-old man was admitted to the hospital complaining of fever, chills, and night sweats of four weeks' duration. He had a mild, nonproductive cough and appeared acutely ill and tremulous. His temperature was 39.8<sup>°</sup>C; pulse rate, 108 beats per minute, and blood pressure, 110/70 mm Hg. A 4-cm diameter supraclavicular lymph node was easily palpable. The chest was clear to auscultation. Total liver span was 20 cm. The spleen could not be felt. Laboratory studies disclosed the following: hematocrit level, 25%; WBC count, 2,800/μL; and differential cell count: 52% segmented neutrophils, 23% band forms, 21% lymphocytes, 1% eosinophils, 1% monocytes, and 2% metamyelocytes. The platelet count was 327,000/μL. His chest
Quantitative Analysis of Styrene Monomer in Polystyrene and Foods Including Some Preliminary Studies of the Uptake and Pharmacodynamics of the Monomer in Rats
Authors: J. R. Withey
Journal: Environmental Health Perspectives (1976)

A variety of food containers, drinking cups and cutlery, fabricated from polystyrene (PS) or polystyrene-related plastic, were analyzed for their styrene monomer content. Samples of yogurt, packaged in PS cups, were similarly analyzed and the leaching of styrene monomer from PS containers by some food simulants was also determined. Blood level studies with rats, dosed with styrene monomer by various routes, illustrated uptake phenomena that were dependent on the dose and route of administration and were also affected by the vehicle used to convey the styrene monomer.
FLATFOOT AS A CAUSE OF PARESTHETIC MERALGIA.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osteoporosis Drugs
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INTERLINGUA
Authors: John Lansbury
Journal: JAMA (1960)

<h3>To the Editor:—</h3> It appears that Professor Giorgio Canuto's criticism ofThe Journal's use of Interlingua summaries stems from a misunderstanding on his part of the motives for them. As an active Esperantist, he is, no doubt, working for the establishment of Esperanto as a world language, whereasThe Journalis not primarily interested in establishing either Interlingua or any other language in this role but is merely trying to make summaries available to the greatest possible number of readers. For this purpose, the first-sight intelligibility of Interlingua makes it immediately usable in the present world situation, and it is therefore the logical choice for this role. Unfortunately, Esperanto cannot be very useful in this role because it has to be learned before it can be read, and this has greatly retarded its spread. The truth is that the vast majority of scientists have refused to learn it, even
Otitis media in Alaskan Eskimo children. Prospective evaluation of chemoprophylaxis
Authors: J. E. Maynard
Journal: JAMA (1972)

In Alaska, acute suppurative otitis media has been reported as the second most frequent cause of morbidity in Aleut, Indian, and Eskimo children. A one-year double-blind prospective trial of ampicillin anhydrous taken orally as a prophylactic by 364 Eskimo children under the age of 7, residing in six villages in western Alaska, showed a 47% reduction in the incidence of otitis media. However, for children who took their medication well, the reduction in incidence was 67%.
Cataract extraction rates and insurance status
Authors: C. H. Kliger
Journal: JAMA (1997)

<h3>In Reply.</h3> —Dr Dahl asserts that the large differences we found in rates of cataract extraction for Medicare patients in FFS and prepaid settings do not result from financial incentives affecting ophthalmologists in the prepaid settings. Dahl refers to the fact that cataract extraction rates in the staff-model and IPA settings were similar even though, as he incorrectly asserts, IPA ophthalmologists were reimbursed "at a higher level than traditional Medicare." Our study demonstrated variations in rates between settings with very different financial and organizational incentives, but it cannot discern at which level these incentives are operating. Nevertheless, we believe it is naive to contend that financial incentives are not affecting ophthalmologists. In the IPAs we studied, ophthalmologists were reimbursed on a discounted FFS basis with rates that generally were lower than those paid in traditional FFS Medicare, and their behavior could well have been influenced by this. As Dahl states, some of
Corrigendum
Authors:  Weiss
Journal: Neuro-Oncology (2015)

The authors have discovered an error in Table 1, which showed that patient demographics in their study were no different than those treated with placebo on NCI trial 01 -C -0222.The table was improperly labeled.The column labeled Sirolimus is in fact the Placebo group, and the column labeled Placebo is the Sirolimus group.This does not affect the conclusions of the trial as the groups' differences were not statistically or clinically significant.Please find the corrected Table 1 below.The authors regret this error.
Supine cross-table lateral chest roentgenogram for the detection of pericardial effusion
Authors: J. A. Heinsimer
Journal: JAMA (1987)

We performed a prospective, blinded, controlled study to test the hypothesis that supine cross-table lateral chest roentgenograms might have an advantage over conventional lateral chest roentgenograms for the detection of pericardial effusion using the epicardial fat stripe sign. In comparison with echocardiography as the gold standard, we found that supine cross-table lateral chest roentgenograms had greater sensitivity (51%) for pericardial effusions than conventional lateral chest roentgenograms (sensitivity, 31%). Specificity was essentially the same for both techniques. A large pericardial effusion was more readily detected by supine cross-table lateral chest roentgenograms (86%) than by the conventional lateral chest roentgenograms (36%). We conclude that a supine cross-table lateral chest roentgenogram should be included in the evaluation of patients with suspected pericardial effusion or in patients in whom a large cardiac silhouette is detected on a standard chest roentgenogram. (<i>JAMA</i>1987;257:3266-3268)
Exaggerated Response to Toll-like Receptor Agonist Contributes to Excessive TNF Production in Myeloproliferative Neoplasm
Authors: Hew Yeng Lai, Sarah J Morse, Samuel B Luty, Michael R Garbati, J Blair Edmiston, Grover C. Bagby, Brian J. Druker, Angela G Fleischman
Journal: Blood (2014)
THE TRANSMUTATION OF SPECIES IN BACTERIOLOGY.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colorectal Cancer
Authors: Les Rosen
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The articles by Drs Ransohoff and Lang<sup>1</sup>and Ahlquist et al<sup>2</sup>discussed, respectively, the sigmoidoscopic and fecal occult blood weapons used in the war against colorectal cancer that claimed approximately 58 000 lives in 1992 and<i>wounded</i>nearly 156 000<sup>3</sup>people, of whom half will die in the next 5 years. Although Ransohoff and Lang wish for a "comprehensive and practical implementation strategy for screening colorectal cancer at both the clinical and national level," the public must urgently respond to a wake-up call for an all-encompassing colorectal cancer program that clamors for awareness, blares for cost-effective detection and treatment, and whines for research to be prioritized. Despite President Reagan and other prominent individuals acquiring colorectal cancer, the paucity of media coverage on this subject fuels the recurring adage that colorectal cancer is the disease "nobody talks about." Five-year survival rates for colon and rectal
Synaptic Regulation of Mesocorticolimbic Dopamine Neurons
Authors: F. J. White
Journal: Annual Review of Neuroscience (1996)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Mental health consequences and correlates of reported medical student abuse
Authors: J. A. Richman
Journal: JAMA (1992)

<h3>Objective.</h3> —To assess the prevalence, correlates, and mental health consequences of reported medical training—related abuses. <h3>Design.</h3> —A longitudinal cohort study of 137 students surveyed from medical school entrance (time 1) through the winter of the fourth training year (time 4). <h3>Setting.</h3> —A state college of medicine. <h3>Outcome Measures.</h3> —Reported training-related abuses (measured at time 4) and mental health status measured at times 1 and 4 (depressive and anxiety symptoms, hostility, problem drinking, escapist drinking, alcohol consumption levels, and gender role orientations). <h3>Results.</h3> —Seventy-two percent of students reported at least one abusive experience during medical training. Females were significantly more likely than males to report gender discrimination, exclusion from informal settings, discomfort from sexual humor, and unwanted sexual advances. Abuse was significantly related to most psychopathological outcomes, controlling for pre-existing psychopathology. Males low in masculinity and females low in femininity were most likely to report abuse. <h3>Conclusions.</h3> —The data provide further support for the assumption that a high proportion of medical students not only experience the training process as abusive in nature but also suffer measurable psychopathological consequences. Efforts should be made to reform medical education, with a prominent focus on gender role—related issues. (<i>JAMA</i>. 1992;267:692-694)
Children's Tonsils In or Out: A Critical Study of the End Results of Tonsillectomy.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Model for Human Carcinogenesis: Action of Environmental Agents
Authors: Suresh H. Moolgavkar
Journal: Environmental Health Perspectives (1983)

Current statistical prescriptions for low-dosage extrapolation of carcinogenic risk make no distinction between exposure to initiators and exposure to promoters despite the abundant data that these two classes of carcinogens have different modes of action. One reason for this is the lack of an appropriate model. In this paper, a model for carcinogenesis is presented which provides a framework for understanding the roles of "spontaneous" events, hereditary factors, and environmental agents in human carcinogenesis and for interpreting experimental carcinogenesis. This model incorporates two features: transition of target stem cells into cancer cells via an intermediate stage in two irreversible steps and growth and differentiation of normal target and intermediate cells. Cast in mathematical terms, the model can be fitted to age-specific incidence data on human cancers of both children and adults and can illuminate the relative importance of agents that affect transition rates, tissue growth and tissue differentiation. Within the context of the model, initiators act by affecting the transition rates, whereas promoters influence the kinetics of growth, especially of initiated cells. The model provides a good quantitative description of the epidemiology of carcinomas of the breast and of the lung. The data are consistent with the notion that hormones and cigarette smoke act as promoting agents in carcinoma of the breast and of the lung, respectively.