tbuckley/cabot-search huggingface dataset:
Opportunities and Challenges for Reducing Hospital Revisits
Authors: Kumar Dharmarajan, Harlan M. Krumholz
Journal: Annals of Internal Medicine (2015)

Letters3 November 2015Opportunities and Challenges for Reducing Hospital RevisitsKumar Dharmarajan, MD, MBA and Harlan M. Krumholz, MD, SMKumar Dharmarajan, MD, MBAFrom Yale School of Medicine, Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, and Yale School of Public Health, New Haven, Connecticut.Search for more papers by this author and Harlan M. Krumholz, MD, SMFrom Yale School of Medicine, Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, and Yale School of Public Health, New Haven, Connecticut.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5154-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We are intrigued by the idea that predictive factors for readmission may vary in importance over the 30 days after discharge, but Dr. Graham and colleagues' article is unfortunately not in a position to make that determination. The authors do not formally test whether their variables have a statistically significant interaction with time. Therefore, inferring that this relationship exists from the data that are presented is not supported. Moreover, the examined laboratory-based acute physiology score is significantly associated with readmission in both the first 7 days and days 8 to 30 after discharge, which does indicate that, according ... Author, Article, and Disclosure InformationAffiliations: From Yale School of Medicine, Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, and Yale School of Public Health, New Haven, Connecticut.Disclaimer: The content is solely the responsibility of the authors and does not represent the official views of the National Institute on Aging; American Federation for Aging Research; or National Heart, Lung, and Blood Institute.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-0878. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOpportunities and Challenges for Reducing Hospital Revisits Kumar Dharmarajan and Harlan M. Krumholz Opportunities and Challenges for Reducing Hospital Revisits Kelly L. Graham , Michael D. Howell , and Edward R. Marcantonio Opportunities and Challenges for Reducing Hospital Revisits Kelly L. Graham , Michael D. Howell , and Edward R. Marcantonio Metrics 3 November 2015Volume 163, Issue 9Page: 727-728KeywordsAgingBloodDisclosureHeartHospitalizationsLungsOutpatient clinicsToxicity ePublished: 3 November 2015 Issue Published: 3 November 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Handbuch der gesamten Tuberkulose-Therapie. Band II.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amanita phalloides Mushroom Poisoning—Northern California, January 1997
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation
Authors: Luba Dumenco, Delphine Oguey, Justina Wu, Norma Messier, Nelson Fausto
Journal: Hepatology (1995)

The p53 gene is frequently mutated in human tumors; in hepatocellular carcinomas, there is a high frequency of a specific mutation at codon 249 in regions with significant aflatoxin exposure. To assess the role of this p53 mutation in the development of hepatocellular carcinoma, a mutant murine p53 gene, p53ser246, which corresponds to human codon 249, was transfected into a differentiated, nontransformed hepatocyte cell line AML12. Expression of p53ser246 in this line resulted in a growth advantage when compared with either a control vector (which contains a large p53 deletion) or with a different p53 mutant, val135, not found in hepatocellular carcinoma. Overall, there was a threefold increase in colony formation after transfection with p53ser246 as compared with the control or p53val135 vectors, and the p53ser246 plates developed consistently larger colonies. Whereas clones expressing the control or p53val135 constructs showed no significant morphological changes, clones expressing p53ser246 showed increased heterogeneity (large multinucleated cells and areas of small crowded cells) without focus formation. In addition, the ser246 mutation imparted a growth advantage in serum-free media, suggesting less dependence on specific factors present in serum. None of the mutant p53 or control lines were capable of growth in soft agar or tumor formation in nude mice. Thus in this model, in which endogenous wild-type p53 expression is retained, a high level of mutant p53 expression is not sufficient to transform hepatocytes. Our findings indicate that p53ser246 has effects on hepatocytes that may result in a clonal growth advantage and suggest that additional factors are required for the development of hepatocellular carcinoma. (Hepatology 1995; 22:1279-1288.).
Hyperthyroidism from thyroid metastasis of pancreatic adenocarcinoma
Authors: M. Eriksson
Journal: JAMA (1977)

A nontender goiter rapidly developed in a 54-year-old patient with suspected disseminated carcinoma. Thyroid function tests showed increased thyroxine, triiodothyronine resin uptake, free thyroxine index, and free thyroxine. Radioactive iodine uptake by the gland was near zero, and thyroid-stimulating hormone (TSH) was undetectable. Histologic examination of the thyroid before and after death showed invasion and disruption of the thyroid follicles by adenocarcinoma (pancreatic primary). Release of thyroglobulin by follicular disruption probably resulted in hyperthyroxinemia and suppression of TSH and radioactive iodine uptake, as occurs in subacute thyroiditis. (<i>JAMA</i>238:1276-1278, 1977)
Use of oral contraceptives by women with epilepsy
Authors: R. H. Mattson
Journal: JAMA (1986)

Oral contraceptives have not been associated with exacerbation of epilepsy despite warnings in package inserts. No clinical study has provided scientific evidence of worsening of seizures in epileptic women who use oral contraceptives, and improvement in seizure control has occurred in some cases. The main concern about use of oral contraceptives in this population is their effectiveness in preventing conception. Failure rates are higher in groups of women taking enzyme-inducing antiepileptic drugs. The degree of increased metabolism of estrogen and progestin components is highly variable and unpredictable among individuals. Use of higher doses increases protection against conception but also increases the risk of side effects, particularly in patients in whom no enzyme induction occurs. The strength of hormones in the pill should be selected individually when initiating use. Some women may require higher doses for full contraceptive effect. (<i>JAMA</i>1986;256:238-240)
Mortality Experience in Relation to a Measured Arsenic Trioxide Exposure
Authors: Sherman S. Pinto, Philip E. Enterline, Vivian Henderson, Michael O. Varner
Journal: Environmental Health Perspectives (1977)

This report examines the mortality experience of 527 men who retired from a copper smelter where they were exposed to airborne arsenic trioxide. Urinary arsenic values of all plant employees were determined in 1973, and the relative arsenic exposure in the various departments of the plant were determined. The relationship of airborne arsenic concentrations to urinary arsenic values was studied in a separate experiment, and the feasibility of using urinary arsenic values as a measure of arsenic exposure was established.The mortality experience of the cohort under study showed them to have a mortality 12.2% higher than was found for males of the same area at the same ages and in the same time period. The excess mortality was due chiefly to respiratory cancer. When the deaths were classified by total lifetime arsenic exposure, the respiratory cancer mortality was linearly related to the amount of exposure. The 1973 figures for arsenic exposure underestimated the exposure of the cohort group by a factor of possibly 10. Evidence was obtained which suggests that after removal from arsenic exposure, the risk of lung cancer declines.Certain of the data which are presented suggests there may be a threshold value for airborne arsenic trioxide exposure below which no adverse effects may be expected.
Characterization and Reconstruction of Historical London, England, Acidic Aerosol Concentrations
Authors: Kazuhiko Ito, George D. Thurston
Journal: Environmental Health Perspectives (1989)

Several past studies of the historical London air pollution record have reported an association between daily mortality and British Smoke levels. However, this pollution index does not give direct information on particulate mass or its chemical composition. A more specific particulate matter index, aerosol acidity, was measured at a site in central London, and daily data are available for the period 1963-1972. British Smoke and SO2 were also measured at the same site. Also, meteorological parameters were routinely measured at a nearby British Meteorological Office. Thus, daily fluctuation of the acidic aerosols was characterized in terms of other environmental parameters. Each of the other parameters analyzed seems necessary, but not sufficient to explain a high level of acidic aerosol. Overall, about half of the variance of log-transformed daily fluctuations of acidic aerosols can be explained by a combination of parameters including SO2 and British Smoke concentrations, temperature, ventilation by wind, and humidity. The rest of the variance cannot be explained by the parameters included in this analysis. Potential factors responsible for this unique variance would be variations in the availability of basic gases to cause neutralization and variation in the availability of catalytic metal salts. Because the acidic aerosol has a unique component of variation, it may be possible to distinguish health effects due to this specific pollutant from other available pollution indices or environmental factors.
Treatment of HIV‐associated multicentric Castleman's disease with oral etoposide
Authors: Duncan Scott, Lisa Cabral, William J. Harrington
Journal: American Journal of Hematology (2001)

Multicentric Castleman's disease (MCD) is a lymphoproliferative disorder that can be defined based upon both clinical and pathological characteristics. The clinical features of this frequently fatal disease include fever, generalized lymphadenopathy, fatigue, splenomegaly, hepatomegaly, and pancytopenia. Recently, severe forms of this disease have been diagnosed in HIV positive patients. Human herpesvirus type 8 (HHV-8) DNA sequences have been detected in peripheral blood mononuclear cells (PBMCs) of patients with Kaposi's sarcoma and MCD, regardless of HIV infection status. Treatment and outcomes in HIV associated MCD are generally unfavorable. We recently treated two HIV-positive patients diagnosed with aggressive MCD with daily oral etoposide (50 mg). The first patient had relapsed on several occasions despite previous therapy with doxil, paclitaxel, and oral ganciclovir. The second patient was treatment naive. Both patients had HHV-8 detectable by polymerase chain reaction in PBMCs, widespread tumor, and B-type symptoms when therapy was initiated. In both cases remissions (documented by computerized tomography) have been durable, 1.5 and 6 months, respectively, with minimal side effects. Oral etoposide may be a safe, tolerable, and active agent in MCD. Am. J. Hematol. 66:148–150, 2001. © 2001 Wiley-Liss, Inc.
A Pandemic on the Horizon
Authors: Liam Donaldson
Journal: Journal of the Royal Society of Medicine (2006)

A pandemic of human influenza is on the horizon: the question is not whether it will arrive but when. Knowing that a pandemic is coming provides an opportunity to plan ahead to mitigate against its impact. However, there are inevitably many uncertainties and managing these, under a constant media spotlight, is an additional and novel challenge.
Surgical Pathology
Authors: Nancy E. Warner
Journal: JAMA (1969)

The best work of its kind today, Ackerman and Butcher's<i>Surgical Pathology</i>has become the standard in the field. The new fourth edition contains substantial additions, and though less than five years have passed since the last edition, readers will want to replace the old version. The basic organization and content remain the same, but all chapters are updated, and some sections revised extensively. Over 500 references and 100 figures have been added, and quality of illustrations remains excellent throughout. Despite additions, the total number of pages is less, and the book is somewhat easier to handle; the format has changed to double column, with the text broken into smaller paragraphs. The many excellent chapters which constitute the backbone of the book are Ackerman's work. Words of wisdom and caution concerning pitfalls in diagnosis are well chosen and authoritative, by virtue of his long experience. Clinicopathologic correlations again have been
Treatment for Sleep Apnea in People without Symptoms
Journal: Annals of Internal Medicine (2001)

Summaries for Patients5 June 2001Treatment for Sleep Apnea in People without SymptomsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-11-200106050-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?During sleep, some people stop breathing for short periods, a condition known as sleep apnea. This partly awakens them and prevents them from achieving normal, restful sleep. Many people with sleep apnea feel bad, have difficulty thinking clearly, and suffer from daytime sleepiness. These symptoms can be troublesome, or even dangerous (if, for example, the affected person falls asleep while driving a car). The usual treatment for this problem involves wearing a special mask during sleep that uses air pressure to keep the breathing passages open (continuous positive ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Treatment with Continuous Positive Airway Pressure Is Not Effective in Patients with Sleep Apnea but No Daytime Sleepiness. A Randomized, Controlled Trial.” It is in the 5 June 2001 issue of Annals of Internal Medicine (volume 134, pages 1015-1023). The authors are F Barbé, LR Mayoralas, J Duran, JF Masa, A Maimó, JM Montserrat, C Monasterio, M Bosch, A Ladaria, M Rubio, R Rubio, M Medinas, L Hernandez, S Vidal, NJ Douglas, and AGN Agustí.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTreatment with Continuous Positive Airway Pressure Is Not Effective in Patients with Sleep Apnea but No Daytime Sleepiness Ferran Barbé , Lola R. Mayoralas , Joaquin Duran , Juan F. Masa , Andreu Maimó , Josep M. Montserrat , Carmen Monasterio , Margalida Bosch , Antoni Ladaria , Manuela Rubio , Ramon Rubio , Magdalena Medinas , Lourdes Hernandez , Silvia Vidal , Neil J. Douglas , and Alvar G.N. Agustí Metrics 5 June 2001Volume 134, Issue 11Page: I-8KeywordsBlood pressureBreathingContinuous positive airway pressureFallsMemoryMental functioningPatientsQuality of lifeSleepSleep apnea ePublished: 5 June 2001 Issue Published: 5 June 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Futility
Authors: Samir K. Shah
Journal: Annals of Internal Medicine (2014)

On Being a Doctor21 January 2014FutilitySamir K. Shah, MDSamir K. Shah, MDFrom The Cleveland Clinic Foundation, Cleveland, Ohio.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M13-1050 Audio Reading - “Futility” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Futility," by S.K. Shah. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this era of increasingly cost-conscious health care, there has been much discussion about end-of-life care. The statistics behind the disproportionate expenditure in the terminal months of life and the accompanying dismal clinical outcomes have become a staple of any presentation on the topic. Although this sort of fine economic and policy analysis has provided insight into the problem, it neglects an essentially human barrier to avoiding futile care, a problem that was brought home to me as a resident on a recent surgery call.The consult for Ms. K came late at night. It was from the cardiac surgery ... Author, Article, and Disclosure InformationAffiliations: From The Cleveland Clinic Foundation, Cleveland, Ohio.Corresponding Author: Samir K. Shah, MD, Department of General Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A100, Cleveland, OH 44195; e-mail, samirkshah.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Futility” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Futility," by S.K. Shah. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetailsSee AlsoFutility: Another Way? Joanne Lynn Futility: Another Way? Steven M. Radwany Futility: Another Way? Simon Kassabian Futility: Another Way? Keyvan Ravakhah Futility: Another Way? Samir K. Shah Futility: Another Way? Keyvan Ravakhah Futility: Another Way? Samir K. Shah Futility: Another Way? Joanne Lynn Futility: Another Way? Simon Kassabian Futility: Another Way? Steven M. Radwany Metrics Cited byFutility: Another Way?Joanne Lynn, MD, MA, MSFutility: Another Way?Steven M. Radwany, MDFutility: Another Way?Simon Kassabian, MDFutility: Another Way?Keyvan Ravakhah, MD, MBA 21 January 2014Volume 160, Issue 2Page: 138-139KeywordsCardiac surgeryExtracorporeal membrane oxygenationHealth careResearch laboratoriesRhabdomyolysisSepsisSubarachnoid hemorrhageSurgeonsSurgeryVasopressors ePublished: 21 January 2014 Issue Published: 21 January 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...