tbuckley/cabot-search huggingface dataset:
JAMA Pediatrics
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Miriam Cintron, Paul Ruich, Diane Cannon, Connie Manno, Fred Marshall, Catherine Copyreaders, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Kenneth King, Donna Lane, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Kathryn Brokke, Lenette Gardner-Gullens, Fanny Brown, Paul Frank, Peter Kim, Rachell Lozano, Michaela Mark, Elizabeth Scientifi, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Will English, Mustafa Ishaq, Daniel Morrow, Reuben Rios, Ronna Henry, Joshua Bird, Karen Bucher, Samantha Welker, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Easley Vice, Brian Shields, Monica Smith, Jeff Ery, J Bonistalli Manager, Kathy Russell, Mirna Monal, Tim Melroy, Marketing Thornbury, Tricia Classifi, Thalia Moss, Mike Harvey, Susan Henning, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Natasha Nekola, Ron Thomas, Paul Gee, Matt Herron, Elizabeth Solaro, Geoff Rey, Rick Bell, Lindsay Dawson, Craig Mccaff Rey, Michael Mcgraw, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Denise Steinhauser, Joe Advertising, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Dimitri Christakis, Washington Joff, Ron Keren, Debra Palazzi, Suzanne Shuey, Samir Shah, Howard Bauchner, Frederick Rivara, Joyce Lee, Ann Arbor, Jay Berry, Cherrie Boyer, San Francisco, Maria Britto, John Campo, Aaron Carroll, Indiana Frank, Joseph Chaloupka, Mitchell Cohen, Sandra Friedman, Kathleen Colorado, Iowa Janz, Terry City, Joyce Klassen, Ann Lee, Michigan Arbor, Huckaby Michelle, Aaron Lewis, Shawn Milstone, Samir Rangel, Martha Shah, Jean-Claude Carel, Shabir Madhi, Ben Marais, Frank Oberklaid, Susan Sawyer, Joan-Carles Surís
Journal: JAMA Pediatrics (2015)
"The Doctor."
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exposure to Regular Gasoline and Ethanol Oxyfuel during Refueling in Alaska
Authors: Lorraine C. Backer, Grace M. Egeland, David L. Ashley, Nicholas J. Lawryk, Clifford P. Weisel, Mary C. White, Tim Bundy, Eric Shortt, John P. Middaugh
Journal: Environmental Health Perspectives (1997)

Although most people are thought to receive their highest acute exposures to gasoline while refueling, relatively little is actually known about personal, nonoccupational exposures to gasoline during refueling activities. This study was designed to measure exposures associated with the use of an oxygenated fuel under cold conditions in Fairbanks, Alaska. We compared concentrations of gasoline components in the blood and in the personal breathing zone (PBZ) of people who pumped regular unleaded gasoline (referred to as regular gasoline) with concentrations in the blood of those who pumped an oxygenated fuel that was 10% ethanol (E-10). A subset of participants in a wintertime engine performance study provided blood samples before and after pumping gasoline (30 using regular gasoline and 30 using E-10). The biological and environmental samples were analyzed for selected aromatic volatile organic compounds (VOCs) found in gasoline (benzene, ethylbenzene, toluene, m-/p-xylene, and o-xylene); the biological samples were also analyzed for three chemicals not found in gasoline (1,4-dichlorobenzene, chloroform, and styrene). People in our study had significantly higher levels of gasoline components in their blood after pumping gasoline than they had before pumping gasoline. The changes in VOC levels in blood were similar whether the individuals pumped regular gasoline or the E-10 blend. The analysis of PBZ samples indicated that there were also measurable levels of gasoline components in the air during refueling. The VOC levels in PBZ air were similar for the two groups. In this study, we demonstrate that people are briefly exposed to low (ppm and sub-ppm) levels of known carcinogens and other potentially toxic compounds while pumping gasoline, regardless of the type of gasoline used.
Sickle-Cell Anemia: Molecular and Cellular Bases of Therapeutic Approaches
Authors: Jurrien Dean, Alan N. Schechter
Journal: New England Journal of Medicine (1978)

Evaluation of New TherapiesTo facilitate the application of the previously discussed assays of gelation, sickling and rheology to new drugs, the Sickle Cell Disease Branch of the National Heart, Lung, and Blood Institute is establishing a laboratory and an advisory policy board to evaluate the efficacy of potential anti-sickling agents.242 This step is necessary because few laboratories have sufficient scientific and financial resources to evaluate potential drugs with a wide spectrum of technics. As a bare minimum, putative agents should be tested for their ability to inhibit cell sickling at a low oxygen tension, to . . .
Psychological interventions can reduce depressive disorders in community settings
Journal: BMJ (2000)

Vaccines may have non-specific effects in developing countriesAlthough studies have found that vaccination against measles may have a non-specific beneficial effect in developing countries, the effect of other routine immunisations has not been assessed.On p 1435 Kristensen et al examined the mortality in vaccinated and unvaccinated children in rural Guinea-Bissau.Both BCG and measles vaccines were associated with reductions in mortality that could not be explained by the prevention of measles or tuberculosis.Polio and diphtheria, tetanus, and pertussis vaccines were associated with higher mortality.Since different vaccines were associated with opposite tendencies, selection biases are unlikely to explain these associations fully.The authors conclude that non-specific effects may occur with many routine vaccinations in areas with high mortality and should be considered when planning immunisation programmes.
A multicenter, randomized, controlled trial comparing the occurrence of major adverse cardiovascular events (MACEs) in patients (pts) with prostate cancer (pc) and cardiovascular disease (CVD) receiving degarelix (GnRH receptor antagonist) or leuprolide (GnRH receptor agonist).
Authors: Susan F. Slovin, Chiara Melloni, Samreen Mansor-Lefebvre, Anders Neijber, Matthew Roe
Journal: Journal of Clinical Oncology (2018)

TPS5101 Background: Background: Epidemiological studies showed an association between GnRH agonists and a long-term increased risk of CVD, early after treatment initiation and with a higher risk seen in pts with pre-existing CVD. Retrospective pooled safety analyses of 6 randomized trials showed that significantly fewer pts treated with the GnRH receptor antagonists, degarelix, had a CV event or death compared with pts receiving a GnRH receptor agonist. In those studies showing an increased CV risk, Androgen-Deprivation Therapy (ADT) was primarily with GnRH receptor agonists. The mechanistic differences between GnRH antagonists and agonists, including testosterone surge and time to suppression at initiation, effect on follicle-stimulating hormone and on GnRH receptors e.g. T-lymphocytes in atherosclerotic plaque, raises the possibility of different CV risk profiles. The PRONOUNCE trial is the first to prospectively assess whether a GnRH agonist/antagonist can worsen pre-existing CVD; assess the impact of GnRH agonist/antagonist on CV risk biomarkers; and effects on the immune system. Methods: PRONOUNCE is a multi-center, randomized, controlled trial of 900 men with pc and concomitant CVD, assessing adjudicated MACEs, i.e. myocardial infarction (fatal, non-fatal), stroke (fatal, non-fatal), or death in pts randomized 1:1 to either degarelix or leuprolide according to label recommendations for up to one year. Eligibility include pre-defined CVD, metastatic or locally advanced pc; high-risk disease with plan for definitive radiation therapy (RT); recurrence after local therapy with PSA doubling time < 12 months; or salvage RT with neoadjuvant/adjuvant ADT for at least 12 months. Serum samples are collected for the analysis of various CV, inflammatory, and immune biomarkers. The primary endpoint will be based on Kaplan-Meier estimator of survival function and stratified for age group and region. Interim analysis is scheduled when 50% of MACE events have occurred allowing the DSMB to recommend for sample size correction. Clinical trial information: NCTO2663908.
Highlights
Authors: Howard Bauchner, Lawrence Gostin, Phil Fontanarosa
Journal: JAMA (2015)

In an analysis of 1993-2012 data from the Nationwide Inpatient Sample, Jain and colleagues assessed trends in acute traumatic spinal cord injury (SCI) incidence, etiology, mortality, and associated surgical procedures.Among their fi ndings was that the incidence of acute traumatic SCI remained relatively stable, with the largest increase observed in the elderly-an increase largely attributed to falls.
Infections in heroin addicts
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predicting acute care use following initiation of systemic therapy for solid tumors.
Authors: Robert C Grant, Rahim Moineddin, Zhan Yao, Melanie Lynn Powis, Ruth Croxford, Eva Grunfeld, Vishal Kukreti, Monika K. Krzyzanowska
Journal: Journal of Clinical Oncology (2018)

6576 Background: Emergency department (ED) visits and hospitalizations are undesirable and costly. We developed and validated the PROACCT (Prediction Of Acute Care use during Cancer Treatment) score to predict at least one acute care visit during the first 30 days (AC30) after initiating systemic therapy for cancer. Methods: Using administrative data, we identified patients in Ontario with the 18 most common non-hematological cancers who initiated non-hormonal systemic treatment regimens between July 1, 2014 and June 30, 2015, randomly split into development and validation cohorts. We created a score to predict AC30 using multivariate logistic regression and backward covariate selection in the development cohort. Combinations of tumor sites and regimens were grouped into quintiles based on AC30. The score was assessed in the validation cohort. Results: AC30 occurred in 21% (3561/17144) of patients. Eleven factors predicted AC30 in the development cohort and formed the score: tumor site and regimen (2nd quintile: 2; 3rd-4th: 3; 5th: 4), Aggregated Diagnosis Group comorbidity index (6-10: 1; 11+: 2), recent/concurrent radiation (1), female sex (1), recent ED visit (1), rural residence (1), local health integration network (0, 1 or 2), and Edmonton Symptom Assessment Scale anxiety (4+: 1), lack of appetite (4+: 1), nausea (4+: 1), and tiredness (4+: 1). Among the 196 tumor-regimen combinations, tumors with poor prognoses, such as pancreatic and lung, and platinum- and taxane-containing regimens, carried the highest risk for AC30. The score had c-statistics of 0.66 and 0.65 in the derivation and validation cohorts, respectively (both P< 0.001) (Table). Conclusions: PROACCT identifies factors that predict AC30 in patients with solid tumors starting systemic treatment and could be incorporated into electronic health records to select patients for preventative interventions. AC30 by PROACCT score. AC30/N (%) Score Derivation (N = 11493) Validation (N = 5651) < 3 18/431 (4) 15/216 (7) 3 37/584 (6) 28/324 (9) 4 111/1083 (10) 67/572 (12) 5 223/1596 (14) 122/741 (16) 6 357/1974 (18) 158/925 (17) 7 407/1949 (21) 186/947 (20) 8 358/1514 (25) 217/768 (28) 9 360/1159 (31) 174/542 (32) 10 269/677 (40) 115/333 (35) > 10 220/526 (42) 119/283 (42)
Pneumomediastinum
Authors: William P. Munsell
Journal: JAMA (1967)

Pneumomediastinum is an entity in which free air is found within the mediastinum. It occurs principally in healthy young men and parturient women and is found most frequently without apparent precipitatory cause. Functionally, however, alveolar hyperpressure, pulmonary capillary hypotension, or aveolar wall defects on a localized basis may occur as a result of, or may be associated with an acute, transient, respiratory obstruction, a type found most commonly in parturition, simple cough, emesis, or asthma. The most common symptoms are pain and dyspnea. Fever and leukocytosis without apparent infection are also frequently encountered. With obvious extrathoracic sources of mediastinal air excluded, the criteria for the diagnosis of pneumomediastinum should include the combination of roentgenographic free mediastinal air and subcutaneous emphysema.
Clinical and Angiographic Effects of Chronic Calcium Channel Blocker Therapy Continued Beyond First Postoperative Year in Patients With Radial Artery Grafts
Authors: Mario Gaudino, Franco Glieca, Nicola Luciani, Francesco Alessandrini, Gianfederico Possati
Journal: Circulation (2001)

Background This study was conceived to elucidate the clinical and angiographic effects of chronic calcium channel blocker therapy (CCCBT) continued after the first postoperative year in patients in whom the radial artery (RA) was used for myocardial revascularization. Methods and Results Patients who received RA grafts at our institution and who at 1 year had no scintigraphic evidence of ischemia in the RA territory or angiographic evidence of RA malfunction (n=120) were randomly assigned to continue (n=63) or suspend (n=57) the CCCBT with diltiazem (120 mg/d). After 5 years, all patients were reassessed clinically and by stress myocardial scintigraphy, and 87 of them (45 from the continued group that continued CCCBT and 42 from the group that suspended CCCBT) were restudied angiographically. No differences regarding either the clinical and scintigraphic results or the RA angiographic status were demonstrated between the 2 groups. Conclusions After the first postoperative year, the continuation of CCCBT does not affect RA graft patency or clinical and scintigraphic results.
Need for U40 insulin
Authors: J. P. Maher
Journal: JAMA (1979)

<h3>In Reply.—</h3> We agree that measurement of serum chromium is probably the most difficult aspect of the entire case report. The confusing situation is not confined to chromium but seems to permeate most of the trace metal literature. Perhaps this is understandable because of the rather recent interest in this area and because the field has not as yet matured.
Effectiveness of multicomponent lower extremity injury prevention programmes in team-sport athletes: an umbrella review
Authors: Romana Brunner, Bernd Friesenbichler, Nicola C Casartelli, Mario Bizzini, Nicola A Maffiuletti, Karin Niedermann
Journal: British Journal of Sports Medicine (2018)

To identify which exercise combinations are most effective as part of a lower extremity injury prevention programme for team-sport athletes.
Organizations
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal Rat-Bite Fever—Florida and Washington, 2003
Journal: JAMA (2005)

Rat-bite fever (RBF) is a rare, systemic illness caused by infection with Streptobacillus moniliformis. RBF has a case-fatality rate of 7%-10% among untreated patients. S. moniliformis is commonly found in the nasal and oropharyngeal flora of rats. Human infection can result from a bite or scratch from an infected or colonized rat, handling of an infected rat, or ingestion of food or water contaminated with infected rat excreta. An abrupt onset of fever, myalgias, arthralgias, vomiting, and headache typically occurs within 2-10 days of exposure and is usually followed by a maculopapular rash on the extremities. This report summarizes the clinical course and exposure history of two rapidly fatal cases of RBF identified by the CDC Unexplained Deaths and Critical Illnesses (UNEX) Project in 2003. These cases underscore the importance of 1) including RBF in the differential diagnoses of acutely ill patients with reported rat exposures and 2) preventing zoonotic infections among persons with occupational or recreational exposure to rats.
NECROLOGICAL.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive Value of Hormone Measurements in Maternal and Fetal Complications of Pregnancy
Authors: F. M. Reis
Journal: Endocrine Reviews (2002)

Intrauterine tissues (placenta, amnion, chorion, decidua) express hormones and cytokines that play a decisive role in maternal-fetal physiological interactions. The excessive or deficient release of some placental hormones in association with gestational diseases may reflect an abnormal differentiation of the placenta, an impaired fetal metabolism, or an adaptive response of the feto-placental unit to adverse conditions. This review is focused on the applicability of hormone measurements in the risk assessment, early diagnosis, and management of pregnancies complicated by Down's syndrome, fetal growth restriction, preeclampsia, preterm delivery, and diabetes mellitus. Combined hormonal tests or the combination of hormones and ultrasound may achieve reasonable sensitivity, but research continues to simplify the screening programs without sacrificing their accuracy. Only in a few instances is there sufficient evidence to firmly recommend the routine use of hormone tests to predict maternal and fetal complications, but the judicious use of selected tests may enhance the sensitivity of the risk assessment based solely on clinical and ultrasound examination.
THE BLOOD PLATES.THEIR NUMERATION IN PHYSIOLOGY AND PATHOLOGY.
Authors: GEORGE T. KEMP
Journal: JAMA (1906)

<h3>INTRODUCTION.</h3> The blood plates have always had a special interest for me, since they were the subject of my thesis for the doctorate in 1886. At that time I suggested a method for their enumeration which involved the use of osmic acid as a fixative. This worked very well for the blood plates, but tended to clump the red corpuscles so that in making comparative counts the results were so unsatisfactory that I did not publish them. About six years ago I took up the work again, using formaldehyd in physiologic salt solution as a fixative, and found this method to be a success. In consulting the literature, up to that time, so many new and interesting problems were suggested that I have given as much time as I could spare to their investigation, and have also assigned such research for thesis work to graduate students in my department at