tbuckley/cabot-search huggingface dataset:
Hajj: journey of a lifetime
Journal: BMJ (2005)

transformation seems to be higher in cardioembolic stroke.w38 w39 Whether asymptomatic haemorrhagic transformation significantly influences early or long term outcome is debatable.Conversion of asymptomatic haemorrhagic transformation into symptomatic intracerebral haemorrhage with early anticoagulation, however, would be a legitimate concern.Factors leading to haemorrhagic transformation (for example, duration of ischaemia, speed of recanalisation, baseline neurological status, and demographic and imaging characteristics) may help in the timing of anticoagulation in the future.w40 w41 There is some information but no randomised controlled trials about resuming anticoagulation in patients with intracerebral haemorrhage and prosthetic heart valves. 24w42-w44 There is no information on how soon anticoagulation could be started safely, if at all, in patients with atrial fibrillation after intracerebral haemorrhage. OutcomeAfter our patient's intracerebral haemorrhage, we identified control of blood pressure and diabetes as the areas needing most attention.Overall compliance rather than truly "difficult to control" hypertension seemed to be the problem.We started him on warfarin two weeks after the second (ischaemic) stroke while recognising that he was a very high risk both for future thromboembolism and for intracerebral haemorrhage and therefore would need very close monitoring.He did not make any substantial functional recovery and needed care in a nursing home.However, lately he has been showing some signs of improvement.His blood pressure, international normalised ratio, and diabetes are being regularly monitored.Supervision in the care home has improved compliance with medication.We acknowledge the lack of evidence for prescribing dipyridamole in preference to aspirin.We also recognise that the area is full of uncertainties, and owing to lack of clear evidence we have not been able to manage the dilemmas with full confidence.We hope that the debate generated by this case might focus researchers' attention on this very important area.We need large scale, well designed trials to help us advise our patients more appropriately in this particularly complex situation.
Hemodynamic changes after ligation of a major branch of the portal vein in rats: Comparison with rats with portal vein constriction
Authors: S Um
Journal: Hepatology (1994)

In chronic portal-hypertensive rat models, such as portal vein constriction or cirrhosis, the portal blood flow that effectively perfuses the hepatocytes is substantially reduced because of anatomical or functional shunts. It is possible therefore that a feedback mechanism from the liver to the splanchnic bed is responsible for the splanchnic hyperemia observed in chronic portal hypertension. To investigate the possible role of such a feedback mechanism, we examined the chronological changes in both portal and systemic hemodynamics in rats after ligation of a major branch of the portal vein that supplies about 80 of the liver circulation. Rats submitted to sham surgery and portal vein–constricted rats were also studied. Blood flow and portal-systemic shunting were measured by radioactive microsphere techniques. For 7 days after portalbranch ligation, transient portal hypertension resulted from an elevated portal resistance. However, no significant changes in portal venous inflow or splanchnic arteriolar resistance were found in the portal branch–ligated rats, whereas in the portal vein–constricted rats significant hyperdynamic changes in these parameters were noted. On the other hand, transient hyperdynamic changes occurred in the systemic circulation during the period from the fourth to the sixth day after portal-branch ligation, similar to those observed in the portal vein–constricted rats. The lack of hyperdynamic changes in the portal territory of the portal branch-ligated rats suggests that the splanchnic hyperemia found in chronic portal-hypertensive states is unlikely to be caused by a feedback mechanism from the ischemic hepatic parenchyma. The transient development of a systemic hyperdynamic circulation during the period when the perfused liver mass has not yet fully hypertrophied after portalbranch ligation suggests that such a hyperdynamic change may be related to the impairment of hepatic function. (Hepatology 1994;19:202–209).
Epidemiology of Alcoholism and Prospects for Treatment
Authors: E. Nace
Journal: Annual Review of Medicine (1984)

This chapter reviews current American drinking patterns and the prevalence of problems resulting from alcohol use. The general population is discussed first. Then a look at five subgroups within the population is presented. These groups are older adults, adolescents, women, Blacks, and Hispanics. For the general population as well as each of the five subgroups, the prospects regarding treatment outcome are discussed.
Pulmonary Tuberculosis
Authors: J. D. Wassersug
Journal: New England Journal of Medicine (1946)

ALTHOUGH a voluminous literature covering the field of pulmonary tuberculosis has appeared during the last year, few outstanding advances have been made. Many papers, however, deserve mention because of their help in the diagnosis and treatment of the disease.Control and Case FindingIn the last few years, since the advent of the miniature roentgenogram, case finding has achieved an unprecedented popularity. Fortified by public funds, the United States Public Health Service and other agencies are now well in the midst of programs to search for tuberculosis in every nook and cranny in this country. As a result, the number . . .
Immunoglobulin on Tumor Cells and Tumor-Induced Lymphocyte Blastogenesis in Human Acute Leukemia
Authors: Jordan U. Gutterman, Roger D. Rossen, William T. Butler, Kenneth B. McCredie, Gerald P. Bodey, Emil J. Freireich, Evan M. Hersh, Barbara J. Culliton
Journal: New England Journal of Medicine (1973)

THE immune system appears to play an important role in determining how a patient will respond to a tumor. Presumably, he has a better chance of survival or, at least, of experiencing remission, if his immune system is alert to the presence of tumor cells. We are not yet certain, however, of the precise mechanism or mechanisms involved in natural tumor immunity. Nor do we fully understand the facets of immune responsiveness that may vary specifically from one type of tumor to another.During the last several years, there has been increasing evidence that tumor-associated antigens are present in a . . .
GEORGE BODINGTON (1799-1882) GENERAL PRACTITIONER
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians and family caregivers. A model for partnership. Council on Scientific Affairs, American Medical Association
Journal: JAMA (1993)

Primary care physicians need a strong and effective model to guide their relationships with family caregivers, key resources for the frail elderly. Caregivers provide a significant proportion of the home care needed by the rapidly growing number of frail elderly living in the community. Caregiving exacts a physical, psychological, social, and emotional toll that no intervention strategies have proven powerful enough to offset. An effective relationship model would acknowledge the key linkage role of the primary care physician, recognize that caregivers and patients form interdependent units, and affirm a care partnership between the physician and caregiver. In this model, the physician conducts periodic assessments of the caregiver as well as the patient; uses a comprehensive home-based approach to care and services; provides training to caregivers, particularly in managing difficult behavior; validates the role of caregiver; and acts as case manager. Educational opportunities and reimbursement structures should be modified to encourage physicians to use the partnership model.
Skin Surgery
Authors: David W. Furnas
Journal: JAMA (1970)

The recent proliferation of weapons designed to attack lesions of the skin has caused this formerly slim 228-page volume to balloon to a bulging 647 pages. This new edition fulfills the need for an updated text which creates order out of a confusing array of procedures (laser, cryoprobes, fluorouracil, immunological agents, electrosurgery, etc). Thirtytwo authors have contributed. <i>Skin Surgery</i>is divided into five sections: general considerations, cold steel surgery, electrosurgery, special procedures, and special locations of diseases. The section on special procedures is particularly rich in new contributions: Mohs, who has dedicated most of a distinguished career to his meticulous, controlled means of chemosurgery, gives a concise overview of this technique and results. Dillaha gives an excellent account of topical application of fluorouracil for keratoses. In a provocative study of immunotherapy, Klein relates how an induced hypersensitivity to topical triethyleneiminobenzoquinone causes the disappearance of extensive keratoses, multiple superficial basal cell
TYPHOID PNEUMONIA.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cellular immune responses to recurring influenza strains have limited boosting ability and limited cross reactivity to other strains.
Authors: Yoav Keynan, Catherine M. Card, Blake T. Ball, Yan Li, Francis A Plummer, Keith R. Fowke
Journal: Clinical Microbiology and Infection (2009)

Influenza vaccine provides protection against infection with matched strains, and this protection correlates with serum antibody titres. In addition to antibodies, influenza-specific CD8+ T-lymphocyte responses are important in decreasing disease severity and facilitating viral clearance. Because this response is directed at internal, relatively conserved antigens, it affords some cross-protection within a given subtype of influenza virus. With the possibility of a broader A(H1N1) Mexico outbreak in the fall of 2009, it appeared worthwhile studying the degree of cellular immune response-mediated cross-reactivity among influenza virus isolates. The composition of the 2006–2007 influenza vaccine included the A/New Caledonia/20/1999 strain (comprising a virus that has been circulating, and was included in vaccine preparations, for 6–7 years) and two strains not previously included (Wisconsin and Malaysia). This combination afforded us the opportunity to determine the degree of cross-reactive cellular immunity after exposure to new viral strains. We analysed the antibody responses and the phenotype and function of the T cell response to vaccine components. The results obtained show that antibody responses to A/New-Caledonia were already high and vaccination did not increase antibody or cytotoxic T lymphocyte responses. These data suggest that repeated exposure to the same influenza stain results in limited boosting of humoral and cellular immune responses.
Dementia
Authors: Janet M. Torpy
Journal: JAMA (2008)

Patient Page is a public service of JAMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA suggests that you consult your physician.This page may be photocopied noncommercially by physicians and other health care professionals to share with patients.To purchase bulk reprints, call 312/464-0776.
Book Reviews
Authors: A.H. Crisp, J. Kamen, G. Potamianos, A.V. Bhat, Ragnhild Husby, Alv A. Dahl, Carl-Ivar Dahl, Astrid Nøklebye Heiberg, Ola M. Olafsen, Lars Weisæth, Ragnhild Husby, Alv A. Dahl, Carl-Ivar Dahl, Astrid Nøklebye Heiberg, Ola M. Olafsen, Lars Weisæth, Ragnhild Husby, Ragnhild Husby, Ragnhild Husby, Graeme J. Taylor, Kenneth Doody, Ranan Rimón, Riikka-Liisa Laakso, Charles Perini, Udo Rauchfleisch, Fritz R. Bühler
Journal: Psychotherapy and Psychosomatics (1985)
Phase II/III Trial of Etoposide and High-Dose Ifosfamide in Newly Diagnosed Metastatic Osteosarcoma: A Pediatric Oncology Group Trial
Authors: Allen M. Goorin, Michael B. Harris, Mark Bernstein, William Ferguson, Meenakshi Devidas, Gene P. Siegal, Mark C. Gebhardt, Cindy L. Schwartz, Michael Link, Holcombe E. Grier
Journal: Journal of Clinical Oncology (2002)

PURPOSE: The objectives of this trial were to estimate the response rate, progression-free survival, and overall survival of patients who received therapy with etoposide and high-dose ifosfamide, and to define the toxicity of this combination when provided with standard chemotherapy in patients with newly diagnosed metastatic osteosarcoma. PATIENTS AND METHODS: Eligible patients received infusions of 100 mg/m 2 per day of etoposide and 3.5 g/m 2 per day of ifosfamide for 5 days. Therapy with granulocyte colony-stimulating factor was begun on day 6. This was repeated 3 weeks after therapy was begun. Response was determined at week 6 by both standard World Health Organization response criteria and by pathologic determination of tumor necrosis of the primary tumor. RESULTS: Forty-three patients were registered; 39 were assessable for response and 41 for toxicity and survival. Twenty-eight (68%) of 41 had metastatic sites only in the lung; 12 (29%) had metastatic sites in other bones with or without lung involvement. Four patients (10%) experienced complete response, and 19 patients (49%) experienced partial response, for an overall response rate of 59% ± 8%. The projected 2-year progression-free survival (PFS) for the 28 patients with metastases to lungs was 39% ± 11%. The projected 2-year PFS for the 12 patients with metastases to other bones (with or without pulmonary metastases) was 58% ± 17%. Two patients died as a result of therapy toxicity. Eighty-three percent of patients had grade 4 neutropenia, and 29% had grade 4 thrombocytopenia. Ten patients (24%) had sepsis. Fanconi’s syndrome was observed in five patients. CONCLUSION: The combination of etoposide and high-dose ifosfamide is effective induction chemotherapy for patients with metastatic osteosarcoma, despite significant associated myelosuppression sometimes complicated by infection and renal toxicity.
Heart
Authors: Rebecca Foust
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiation Therapy Advances for Prostate Cancer
Journal: Cancer Discovery (2016)

Three studies on prostate cancer indicate, respectively, that a hypofractionated schedule of intensity-modulated radiation therapy reduces treatment time without negatively affecting quality of life; treatment with stereotactic body radiotherapy is a powerful, potentially more cost-effective option; and prostate brachytherapy, without external radiation, may be sufficient to control disease progression. The data were presented at the American Society for Radiation Oncology's 2016 annual meeting.
The use of packed red blood cells
Authors: A. J. Grindon
Journal: JAMA (1976)

THE DEVELOPMENT of plastic containers with connected satellite bags for the collection of whole blood ushered in a new era of blood component therapy. Even before that time, it was recognized that a deficiency in red blood cell (RBC) oxygen-carrying capacity was best treated by the transfusion of packed red blood cells (PRBC). Since then, the need to provide ever-increasing amounts of blood components such as platelet concentrate and fresh frozen plasma has provided the impetus for an increase in the use of PRBC. Today, the only remaining legitimate indication for the transfusion of whole blood is acute blood loss. Many transfusion therapists have even advocated giving one third to one half of all transfusions in the operating room as PRBC. Such practice has been shown to be not only possible but successful if combined when necessary with salt solution or plasma protein fraction.<sup>1</sup> Is this ever-increasing emphasis on
407P Long-term effect of peripheral sensory neuropathy (PSN) of 3 or 6 months oxaliplatin-based adjuvant chemotherapy for high-risk stage II colon cancer: ACHIEVE-2 as part of the IDEA collaboration
Authors: M. Kotaka, M. Shiozawa, D. Manaka, Y. Sakamoto, A. Shiomi, A. Makiyama, Y. Munemoto, T. Rikiyama, M. Fukunaga, T. Ueki, K. Shitara, H. Shinkai, N. Tanida, E. Oki, T. Yamanaka, E. Sunami, K. Yamazaki, A. Ohtsu, Y. Maehara, T. Yoshino
Journal: Annals of Oncology (2020)
BILIARY OBSTRUCTION AFER TIPS PLACEMENT IN A LIVER TRANSPLANT RECIPIENT
Authors: P Macinga, D Gogova, J Raupach, L Janousek, E Honsova, P Taimr, J Spicak, J Novotny, J Peregrin, T Hucl
Journal: Endoscopy (2020)

Aims Transjugular intrahepatic portosystemic shunt (TIPS) is a method conventionally used in portal hypertension treatment. Refractory ascites and variceal bleeding are the most common indications. Complications frequently observed include bleeding and development of liver encephalopathy, those affecting the biliary tree as bilioportal fistula and biliary stenosis are much less common. Placement of TIPS in a liver transplant patient is rare and implicate a technically challenging procedure.
Alergia polínica
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute and long-term beta-adrenergic blockade for patients with neurocardiogenic syncope
Authors: Marilyn M. Cox, Bruce A. Perlman, Manuel R. Mayor, Todd A. Silberstein, Ester Levin, Lynn Pringle, Agustin Castellanos, Robert J. Myerburg
Journal: Journal of the American College of Cardiology (1995)

This study was designed to prospectively evaluate the long-term outcome of drug therapy guided by head-up tilt testing for the management of unexplained syncope and near syncope. Head-up tilt testing is used to evaluate patients with unexplained syncope. The validity of acute drug testing and the efficacy of long-term oral therapy for prevention of recurrent syncope have not been investigated in large patient groups. We studied 296 consecutive patients with unexplained syncope or near syncope who underwent 80° head-up tilt testing with and without isoproterenol challenge. The efficacy of intravenous and oral beta-blocker therapy was evaluated by repeat testing. Patients with both positive and negative responses to therapy were followed up for rates of recurrence of syncope. A total of 193 patients (65%) had a positive tilt test response; 89% of these 193 required isoproterenol challenge to elicit this response. Patients with a positive tilt test result had lower values for heart rate at rest (mean ± SD 69 ± 13 vs. 74 ± 14 beats/min, p = 0.046) and systolic blood pressure (137 ± 28 vs. 145 ± 30 mm Hg, p = 0.0018) at baseline than did the patients with a negative tilt test result. Intravenous propranolol blocked the positive response in 163 (90%) of 181 patients retested. Oral beta-blockers were effective by tilt test criteria in 118 (94%) of 125 patients; 12 (10%) had recurrent clinical symptoms while taking beta-blockers. Eight (42%) of 19 patients who had a negative tilt test response during beta-blocker therapy had recurrent symptoms when they stopped therapy. Three (23%) of 13 patients receiving empiric beta-blocker therapy had recurrent symptoms. The follow-up period for the patients with a positive tilt test result was 28 ± 11 months (range 5 to 48). Intravenous propranolol is effective in preventing neurocardiogenic syncope diagnosed during head-up tilt testing and predicts the response to oral beta-blocker therapy. Oral beta-blocker therapy prevents recurrent syncope in the majority of patients. Recurrence of syncope is lowest when efficacy of oral beta-blocker therapy is confirmed by repeat head-up tilt testing.