tbuckley/cabot-search huggingface dataset:
Abstract 2301: Agonistic Autoantibodies Against the Endothelin 1 ETA - and α1-Adrenergic- Receptor in the Sera of Patients with Idiopathic Pulmonary Arterial Hypertension.
Authors: Gerd Wallukat, Michael Dandel, Johannes Müller, Sabine Bartel, Wolfgang Schulze, Roland Hetzer
Journal: Circulation (2007)

Background: Idiopathic pulmonary arterial hypertension (IPAH) is a progressive fatal disease of unknown cause. This disease is accompanied by an massive increase of pulmonary vascular resistance (remodelling and increase of vascular tonus) inducing right heart failure. It was shown that the synthesis of vasoconstrictors (endothelin 1, thromboxane A2, serotonine) is elevated in patients with IPAH. Methods: We analyzed sera of patients with PH with regards to functional autoantibodies (AABs) against G-protein coupled receptors using spontaneously beating rat cardiomyocytes as bioassay. Moreover, we investigated the effect of the AAB on the translocation of the transcription factors NFκB and AP-1. Results: The sera of patients with IPAH contain functional AABs against the α1-adrenergic (α1-AR) and the endothelin1 ETA receptor. We purified the AABs by affinity chromatography. AABs against the α1-AR exert a positive chronotropic effect. AABs against the ETA receptor induce like endothelin 1 a negative chronotropic effect. The agonistic effect of the AABs was dose-dependent and blocked by prazosine (α1-AR blocker) and BQ610 (ETA antagonist), respectively. Moreover, the agonistic effect of the AABs was neutralized by peptides corresponding to the second extracellular loop of both receptors. Therefore, the epitopes of the AABs are localized on the second extracellular loops of the receptors. The α1-AR AABs as well as the ETA-receptor AABs induce a permanent stimulation without desensitization of the receptor mediated signal cascade. The α1-adrenergic agonist phenylephrine and endothelin1 as ET receptor agonist cause a translocation of the transcription factor NFκB and AP-1 from the cytosol into the nucleus in cultured neonatal rat cardiomyocytes. The same translocation was observed using the AABs against the α1-AR and ETA receptor. Conclusion: The agonist-like AABs against the α1-AR and the ETA receptor influence in vitro the signalling of cultured cells. Moreover, the AABs prevent the desensitization of the receptor mediated signal cascade normally seen by ongoing receptor stimulation. Therefore, we assumed that the functional AABs against the α1-AR and the ETA receptor may be involved in the pathogenesis of IPAH.
Stramonium Intoxication
Authors: Kenneth C. Ullman
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Dr. Gowdy's article on stramonium intoxication (221:585, 1972) was quite informative and timely. Belladonna intoxication, its identification and treatment, has occupied our research interest and attention over the past few years. I am afraid, however, that a major mistake has been made in the naming of pilocarpine instead of physostigmine as the drug that we have used as the antidote for scopolamine-induced intoxication.<sup>1,2</sup>We are unaware at this time of any clinical studies reporting the beneficial effects of pilocarpine in relieving both the physical and mental signs of belladonna intoxication.
Fundamental Aspects of Dose-Response Relationships and Their Extrapolation for Noncarcinogenic Effects of Metals
Authors: Gunnar F. Nordberg, Per Strangert
Journal: Environmental Health Perspectives (1978)

Fundamental differences in dose-response relationships between "stochastic" and "nonstochastic" effects of chemicals are identified and discussed.The difficulties in extrapolating into the low-dose region of dose-response curves are pointed out.In some instances of nonstochastic effects, observations concern- ing interindividual variability in biological half-time and threshold body burden for symptoms may be used for such extrapolation.An example based on data from the literature concerning effects of methyl- mercury on the nervous system is given.The confidence intervals of the extrapolated risk-values are computed and discussed in relation to assumptions concerning the mathematical model to be used in the extrapolation process.
HEALING BY THE KING'S TOUCH
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correct levels of serum cholesterol. Average vs normal vs optimal
Authors: I. S. Wright
Journal: JAMA (1976)

THE PROBLEM of what constitutes average, normal, and optimal levels of serum cholesterol and how the results of tests to determine these levels should be applied to clinical practice still bedevils us. High levels of serum cholesterol are associated with an increased incidence of atherosclerosis and death, and a constantly low serum cholesterol level appears protective in this regard. The risk of complications associated with elevated cholesterol levels is increased when other risk factors such as hereditary premature atherosclerosis, hypertension, smoking, and diabetes occur concomitantly. Average levels vary substantially with different ethnic and geographic populations, specific hereditary traits, a number of diseases, and a wide range of dietary habits. This statement is directed to the situation as it exists in the United States today. Leading investigators are now widely recommending that the uppermost acceptable level should be 240 mg/100 ml, based on the standard Abell-Kendall method. This is consistent with
Withdrawal of cyanocobalamin
Authors: A H Goodspeed
Journal: BMJ (1979)

fetal serum AFP that enters the amniotic fluid in the presence of a normal conceptus.Our results and those of Ruoslahti and colleagues emphasise that the AFP con A- binding assay on amniotic fluid has particular value in detecting the presence of communi- cating fetal abnormalities during the period when amniocenteses are usually performed, between the 14th and 18th weeks, in cases where the elevations of amniotic fluid AFP are equivocal or when gestational aging is uncertain.
John Hughlings Jackson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DISINFECTION OF THE URINE FROM CASES OF TYPHOID FEVER.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemical Warfare
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal human cerebral coenurosis
Authors: J. A. Hermos
Journal: JAMA (1970)

<i>A 2-year-old boy from South Dakota died from an intracranial infection due to a parasitic cyst. The cyst was identified as the larval cyst, or coenurus, of the dog tapeworm</i>Taenia multiceps.<i>To our knowledge this is only the second case of cerebral coenurosis reported in the United States. Evidence suggests that rabbits were the intermediate host in this case.</i>
John Peter Mettauer (1787-1875)
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sense and nonsense of influenza vaccination in asthma and chronic obstructive pulmonary disease.
Authors: P H Rothbarth, B M Kempen, M J Sprenger
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Although influenza is generally seen as an important cause of excess mortality in patients with asthma or chronic obstructive pulmonary disease (COPD), this mortality is nearly exclusively present in patients over the age of 60. Morbidity in patients with asthma or COPD is related to respiratory infections, including influenza. Vaccination against influenza has proven to be effective in nursing home populations, decreasing both mortality and morbidity during epidemics of influenza A. In younger patients with asthma or COPD, however, the effect of vaccination is more ambiguous. Exacerbation of respiratory disease is not due to influenza vaccination (except in allergy to chicken protein), from which we can conclude that influenza vaccination is a safe method to prevent a potentially serious respiratory infection in patients with asthma or COPD.
THE INDEX. A REQUEST.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gonococcal arthritis in children
Authors: C. W. Fink
Journal: JAMA (1965)

Six children with gonococcal arthritis were seen at Parkland Memorial Hospital and the Children's Medical Center in Dallas during a 2 1/2-year period. There were five girls and one boy. The clinical manifestations were variable. A migratory polyarthritis with eventual localization in one or more joints was most common. Gonococci were cultured from a joint or the vagina in all but one of the six patients. Sera of all six contained gonococcal antibodies as revealed by the fluorescent antibody technique. A survey of cultures done at both hospitals during the period Jan 1, 1964, through March 31, 1965, has revealed 17 infants and children with culture-positive, nonarthritic gonococcal disease, in addition to the six with gonococcal arthritis.
“NON-MEDICAL HEALING!”
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nicotine replacement therapy during pregnancy
Authors: N. L. Benowitz
Journal: JAMA (1991)

CIGARETTE smoking is a major preventable cause of fetal death and injury, yet many women continue to smoke cigarettes throughout pregnancy. The most effective pharmacologic adjunct to smoking cessation therapy is nicotine replacement, including nicotine chewing gum or transdermal nicotine. However, the use of nicotine replacement therapy is contraindicated during pregnancy. The analysis presented herein suggests that the benefits of nicotine replacement therapy to aid smoking cessation in pregnant women who cannot stop smoking without such therapy substantially outweigh the risks of continued smoking or the risks of nicotine replacement per se. <h3>PREVALENCE OF CIGARETTE SMOKING DURING PREGNANCY</h3> Although the prevalence of smoking has declined in recent years and many women quit smoking when they become pregnant, 20% to 25% of pregnant American women continue to smoke throughout pregnancy; many of these women are heavy smokers. The National Health Interview survey of women pregnant in 1985 or with a birth
Missing Author Contributions Statement
Authors: Judith Rietjens, Lenzo Robijn, Agnes Van Der Heide
Journal: JAMA (2014)

Antonia Kwan, PhD, MRCPCH; Roshini S. Abraham, PhD; Robert Currier, PhD; Amy Brower, PhD; Karen Andruszewski, BS; Jordan K. Abbott, MD; Mei Baker, MD; Mark Ballow, MD; Louis E. Bartoshesky, MD; Vincent R. Bonagura, MD; Francisco A. Bonilla, MD, PhD; Charles Brokopp, DrPH; Edward Brooks, MD; Michele Caggana, ScD; Jocelyn Celestin, MD; Joseph A. Church, MD; Anne Marie Comeau, PhD; James A. Connelly, MD; Morton J. Cowan, MD; Charlotte Cunningham-Rundles, MD; Trivikram Dasu, PhD; Nina Dave, MD; Maria T. De La Morena, MD; Ulrich Duffner, MD; Chin-To Fong, MD; Lisa Forbes, MD; Debra Freedenberg, MD; Erwin W. Gelfand, MD; Jaime E. Hale, BS; I. Celine Hanson, MD; Beverly N. Hay, MD; Diana Hu, MD; Anthony Infante, MD, PhD; Daisy Johnson, BSN; Neena Kapoor, MD; Denise M. Kay, PhD; Donald B. Kohn, MD; Rachel Lee, PhD; Heather Lehman, MD; Zhili Lin, PhD; Fred Lorey, PhD; Aly Abdel-Mageed, MD, MBA; Adrienne Manning, BS; Sean McGhee, MD; Theodore B. Moore, MD; Stanley J. Naides, MD; Luigi D. Notarangelo, MD; Jordan S. Orange, MD; Sung-Yun Pai, MD; Matthew Porteus, MD, PhD; Ray Rodriguez, MD, JD, MPH, MBA; Neil Romberg, MD; John Routes, MD; Mary Ruehle, MS; Arye Rubenstein, MD; Carlos A. Saavedra-Matiz, MD; Ginger Scott, RN; Patricia M. Scott, MT; Elizabeth Secord, MD; Christine Seroogy, MD; William T. Shearer, MD, PhD; Subhadra Siegel, MD; Stacy K. Silvers, MD; E. Richard Stiehm, MD; Robert W. Sugerman, MD; John L. Sullivan, MD; Susan Tanksley, PhD; Millard L. Tierce IV, DO; James Verbsky, MD, PhD; Beth Vogel, MS; Rosalyn Walker, MD; Kelly Walkovich, MD; Jolan E. Walter, MD, PhD; Richard L. Wasserman, MD, PhD; Michael S. Watson, MS, PhD; Geoffrey A. Weinberg, MD; Leonard B. Weiner, MD; Heather Wood, MS; Anne B. Yates, MD; Jennifer M. Puck, MD
Atenolol: side effects in a newborn infant.
Journal: BMJ (1982)

Reversible male subfertility due to hyperthyroidism Hyperthyroidism in women may cause oligomenorrhoea, amenorrhoea, and failure of ovulation.In men gonadal dysfunction is less apparent, though loss of libido, reduced potency,' and gynaecomastia2 may occur.We describe a man who presented with subfertility due to thyrotoxicosis and in whom normal fertility was restored with antithyroid drug treatment. Case reportA 26-year-old man with a one-year history of attempted conception was referred to a male subfertility clinic.Two previous semen analyses had disclosed oligospermia with sperm counts of 11 x 109/1 on both occasions (figure).He had had classical symptoms of thyrotoxicosis for five years and 18 months earlier had been investigated for palpitations.Examination showed a diffuse goitre, tremor, and tachycardia; vitiligo was present on the arms, trunk, and penis.There was no gynaecomastia and the testes were normal.Hyperthyroidism was confirmed biochemically: serum thyroxine concentration was 267 mmol/l (20-7 4g/100 ml) (normal
Scientists Center for Animal Welfare 1983 Journalism Award
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Scientists Center for Animal Welfare 1983 Journalism Award Get access JNCI: Journal of the National Cancer Institute, Volume 70, Issue 6, June 1983, Page 1171, https://doi.org/10.1093/jnci/70.6.1171 Published: 01 June 1983
Experts try education to preserve skiers' knees
Authors: A. A. Skolnick
Journal: JAMA (1996)

BY TOO many accounts, one of the most horrible sounds a skier can hear on a ski slope is the popping noise of the anterior cruciate ligament (ACL) as it tears during a fall. That sound, which usually heralds a painful, debilitating, and expensive knee injury, is heard no less by the most accomplished skiers than by the clumsiest novices. Severe knee sprains are now the most common medically significant injuries among Alpine or downhill skiers. While improvements in ski boots and bindings since the 1970s have greatly reduced fractures and other injuries below the knee, they appear to have done nothing to protect skiers from serious ACL injuries. According to several studies, the rate of severe knee sprains—which usually involve the ACL—has increased more than threefold since the late 1970s. Now, researchers who have spent more than two decades studying video tapes of ski injuries have developed an educational