tbuckley/cabot-search huggingface dataset:
MEDICAL JOURNALS AND WEEKLY EDITIONS.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Neurology (2016)

MacKenzie-Graham and colleagues study the association between localized gray matter (GM) atrophy and clinical disability in a biology-driven analysis of multiple sclerosis (MS).Magnetic resonance images were acquired from 133 women with relapsing-remitting MS and analyzed using voxel-based morphometry and volumetry.These biology-driven data indicate that specifi c disabilities in MS are associated with voxelwise GM loss in distinct locations.
Medications mostly associated with priapism events: Assessment of the 2015-2020 Food and Drug Administration (FDA) pharmacovigilance database entries
Authors: N. Schifano, P. Capogrosso, L. Boeri, E.P. Pozzi, F. Belladelli, S. Chiappini, O.O. Cakir, M. Rewhorn, F. Castiglione, H.M. Alnajjar, A. Muneer, F. Deho’, F. Schifano, F. Montorsi, A. Salonia
Journal: European Urology (2021)
Multistage Models for Carcinogenesis
Authors: David A. Freedman, William C. Navidi
Journal: Environmental Health Perspectives (1989)

The multistage model is tested on several human and animal data sets. It fits in some cases but not in others. With human lung cancer data, there is a drop in risk for ex-smokers quite different from the predictions of the model. The results are not conclusive but are compatible with the view that the multistage model provides a family of curves that often fit cancer incidence data, but may not capture the underlying biological reality.
Serum Angiotensin-Converting Enzyme
Authors: Robert C. Smallridge
Journal: JAMA (1983)

Angiotensin-converting enzyme (ACE) activity was measured in the serum samples of 247 patients with varying thyroid states. In 60 hyperthyroid patients, the mean ( ± SD) ACE level of 29.5 ±9.7 units/mL was higher than in all other groups. The serum ACE level was 17.0 ± 5.1 units/mL in 129 euthyroid subjects and differed from the level of 13.9±5.1 units/mL observed in 34 hypothyroid patients. Twenty-four patients receiving exogenous thyroid hormone had elevated serum thyroxine values. Their mean serum triiodothyronine level was in the normal range, and the mean ACE level did not differ from the euthyroid mean. The mean serum ACE level fell from 30.8 to 17.4 units/mL in 35 hyperthyroid patients studied before and after therapy. In 12 hypothyroid subjects, the mean serum ACE level rose from 11.6 to 15.8 units/mL after thyroid hormone replacement. In eight of ten patients with transient hyperthyroidism (subacute thyroiditis or painless thyrotoxic thyroiditis), their highest ACE levels were observed in the hyperthyroid or transition phase and fell progressively with the lowest values being recorded during the hypothyroid or early recovery phases. Thus, ACE activity may respond to thyroid hormone, and interpretation of serum ACE levels may require knowledge of the patient's thyroid status. Serum ACE may be useful as a probe for exploring peripheral thyroid hormone action. (<i>JAMA</i>1983;250:2489-2493)
Health Centres
Authors: L. Bland
Journal: BMJ (1965)

Tissue eosinophilia prevention represents one of the primary targets to new anti-allergic therapies. As lipoxin A<sub>4</sub> (LXA<sub>4</sub>) and aspirin-triggered 15-epi-LXA<sub>4</sub> (ATL) are emerging as endogenous “stop signals” produced in distinct pathologies including some eosinophil-related pulmonary disorders, we evaluated the impact of in situ LXA<sub>4</sub>/ATL metabolically stable analogues on allergen-induced eosinophilic pleurisy in sensitized rats. LXA<sub>4</sub>/ATL analogues dramatically blocked allergic pleural eosinophil influx, while concurrently increasing circulating eosinophilia, inhibiting the earlier edema and neutrophilia associated with allergic reaction. The mechanisms underlying this LXA<sub>4</sub>/ATL-driven allergic eosinophilia blockade was independent of mast cell degranulation and involved LXA<sub>4</sub>/ATL inhibition of both IL-5 and eotaxin generation, as well as platelet activating factor action. These findings reveal LXA<sub>4</sub>/ATL as a novel class of endogenous anti-allergic mediators, capable of preventing local eosinophilia.
Axillary Hyperhidrosis
Authors: Walter B. Shelley
Journal: JAMA (1975)

<h3>To the Editor.—</h3> We were pleased to note the success Andersen and his colleagues (231:1026, 1975) have had in treating axillary hyperhidrosis in more than 250 patients by the employment of the simple surgical technique we introduced in 1963. Although Andersen states that current "topical treatment of hyperhidrosis of the axillae is, nine times out of ten, ineffective," we would like to record that we have now discovered a<i>topical</i>antiperspirant system that is even more effective than our simple surgical procedure. Although the method was initially outlined last year,<sup>1</sup>it is fully detailed in a forthcoming article.<sup>2</sup> In essence, complete axillary anhidrosis, as demonstrated by sustained garment armpit dryness, could regularly be achieved in hyperhidrotic patients within 48 hours by the following trinary technique: (1) local application of 20% aluminum chloride hexahydrate in anhydrous ethyl alcohol (200-proof); (2) making this application on the dry, unwashed, nonsweating axilla
Patterns of Illness in Rhinovirus Infections of Military Personnel
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GI infections/AIDS
Authors: I Lilja, G Olaison, R Sjodahl, C Tagesson, C Gustafson-Svard, T Villanger, M Veel
Journal: Gut (1994)

Phospholipase A2 (PLA2; EC 3.1.1.4)is a key enzyme in inflammation and is thought to play an important part in inflammatory diseases of the gastroin- testinal tract.Three genetically, biochemically and functionally different forms of PLA2 have been identified in human tissues, two low molecular weight (14 kDa) forms (PLA2-l and PLA2-ll) and one high molecular weight (85 kDa) form (cPLA2).It is still unknown which type of PLA2 that can be found in the human gastrointestinal tract.Here, the presence of PLA2-1, PLA2-11 and cPLA2 mRNA was investigated in the human stomach, ileum and colon.Methods.RNA was isolated from the mucosa of the stomach (1 patient, control of previous bleeding; 1 patient, control of duodenal ulcer), from the distal part of ileum (3 patients operated on for colonic cancer; 2 patients for Crohn's disease), and from the colon (4 patients operated on for colonic cancer).mRNA expression was analysed, using the reverse transcriptase- polymerase chain reaction (RT-PCR).Results.(i) mRNA for PLA2-1, PLA2-ll and cPLA2 was detected in the stom- ach, ileum and colon.(ii) In the ileum and the colon, the mRNA expression of PLA2-ll markedly exceeded that of PLA2-l and cPLA2. (iii) PLA2-ll mRNA was markedly increased in the ileum of patients with Crohn's disease, whereas PLA2-l and cPLA2 mRNA were unaffected.Conclusion.These results indicate that human gastrointestinal mucosa contains mRNA for three different forms of PLA2.Moreover, the results sug- gest that PLA2-11 might be of importance in Crohn's disease.
Electroencephalographic Prediction of Epilepsy as a Complication of Cerebral Palsy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroglia
Authors: Kyung-Whan Min
Journal: JAMA (1996)

The neuroglia, the other important constituents of the central nervous system, have long been thought to exist only to give support to the functional cells, the neurons. Judging by the mere volume and extent of glial cells found in the central nervous system, they should have received more attention than they have enjoyed. Thus I welcome the publication of<i>Neuroglia</i>and congratulate its editors, Helmut Kettermann and Bruce R. Ransom, who have gathered 100 expert contributors to produce a compendium on neuroglial cells of over 1000 pages. The book has 12 sections and 69 chapters. Despite the multiple authorship the text reads as if it had been written by a single author; the format is consistent, and the illustrations are informative. The contents and references are up-to-date taking into account the typical 2-year hiatus of similar publications. The sections are entitled: "Morphology," "Lineage," "Physiology," "Receptors," "Mechanisms of Cell-to-Cell Communication," "Molecular
The International Review of Medical and Surgical Technics.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of depression
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Two editorials by Drs Lundberg (also on p 1879) and Uhlenhuth commenting on an article by Keller et al in that same issue suggest that the finding that many physicians treat major depression with benzodiazepines rather than antidepressants is not such a bad thing, because antidepressants are more dangerous than antianxiety agents. Dr Lundberg finds the use of antidepressants in that situation comparable with giving a loaded revolver or a dagger to a person threatening to attempt suicide. I find this attitude puzzling. Inadequate treatment is not the answer to the problem of adequate treatment that may be dangerous. The answer is the physician taking the time and effort to assess the risk of suicide as carefully as possible and to seek consultation in instances of doubt. This is hardly a foolproof method, but neither is inadequate treatment. It would be interesting to know what the reasons
Perspectives In Aquatic Toxicology
Authors: D. Malins
Journal: The Annual Review of Pharmacology and Toxicology (1991)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Arterial O2 saturation and maximum O2 consumption in moderate-altitude runners exposed to sea level and 3,050 m
Authors: A. Tucker
Journal: JAMA (1984)

Twelve trained runners, who were moderate-altitude (1,520 m) residents, were acutely exposed to sea level and 3,050-m altitude in a hypo-hyperbaric chamber. At 1,520 m, maximum O<sub>2</sub>consumption (V̇o<sub>2</sub>max) was 67.7±0.9 mL/kg/min, minute ventilation (V) at maximum exercise was 169.8 ± 4.6 L/min, and arterial O<sub>2</sub>saturation (Sao<sub>2</sub>) decreased from 93.3% ±0.9% at rest, to 84.5% ±1.6% at maximum exercise. Exposure to 3,050 m produced a lower Vo<sub>2</sub>max (56.5±1.5, —16.5%), a similar V̇ at maximum exercise (169.9 ± 6.0), and a similar fall in Sao<sub>2</sub>(from 89.1%±0.8% to 79.5%±0.8%). Exposure to sea level increased V̇o<sub>2</sub>max to 72.4±1.4 (+6.9%), reduced V̇ at maximum exercise to 158.8 ±6.5, and induced a smaller fall in Sao<sub>2</sub>(from 96.9% ±0.4% to 92.1%± 1.0%). These changes are comparable with those reported previously in athletes at sea level exposed to similar altitudes, suggesting that residence at 1,520 m does not improve V̇o<sub>2</sub>max in highly trained athletes acutely exposed to lower or higher altitudes. (<i>JAMA</i>1984;252:2867-2871)
Meet Vic Cohn— Dean of American Science Writers
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Mitotic recombination effects homozygosity for NF1 germline mutations in neurofibromas
Authors: J Spelbrink, F.-Y Li, V Tiranti, K Nikali, Q.-P Yuan, M Tariq, S Wanrooij, N Garrido, G Comi, L Morandi, L Santoro, A Toscano, G.-M Fabrizi, H Somer, R Croxen, D Beeson, J Poulton, A Suomalainen, H Jacobs, M Zeviani, C Larsson
Journal: Nature Genetics (2001)
Lysosomal and endosomal heterogeneity in the liver: A comparison of the intracellular pathways of endocytosis in rat liver cells
Authors: G Kindberg
Journal: Hepatology (1991)

Air-filled albumin microspheres, asialoorosomucoid and formaldehyde-treated serum albumin are selectively taken up by endocytosis in rat liver Kupffer cells, parenchymal cells and endothelial cells, respectively. Intracellular transport and degradation of endocytosed material were studied by subcellular fractionation in sucrose and Nycodenz gradients after intravenous injection of the ligand. By using ligands labeled with 125I-tyramine—cellobiose, the subcellular distribution of labeled degradation products can be studied because they are trapped at the site of formation. The results show that the kinetics of intracellular transport are different in hepatic parenchymal, endothelial and Kupffer cells. In endothelial cells, the ligand is associated with two types of endosomes during the first minutes after internalization and then is transferred rapidly to the lysosomes. In parenchymal cells, 125I-tyramine-cellobiose-asialoorosomucoid was located in a relatively slowly sedimenting vesicle during the first minute after internalization and subsequently in denser endosomes. Degradation of 125I-tyramine-cellobiose-asialoorosomucoid in parenchymal cells started later than that of 125I-tyramine-cellobiose-formaldehyde-treated serum albumin in endothelial cells. Furthermore, the ligand seemed to be transferred relatively slowly from endosomes to lysosomes, and most of the undegraded ligand was in the endosomes. The rate-limiting step of proteolysis in parenchymal cells is probably the transport from endosomes to lysosomes. In Kupffer cells, most 125I-tyramine-cellobiose-microspheres are found as undegraded material in very dense endosomes up to 3 hr after injection. After 20 hr, most of the ligand is degraded in lysosomes distributed at a lower density than the endosomes in Nycodenz and sucrose gradients. (HEPATOLOGY 1991;13:254–259).
Cracked
Authors: Jack Coulehan
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Altered cardiopulmonary function associated with diseases of the lung. The role of surgery
Authors: W. E. Adams
Journal: JAMA (1966)

Altered pulmonary function in patients with L surgical lesions of the lungs is being encountered with increasing frequency. Primary tumor of the lung occurring in patients with pulmonary emphysema or fibrosis is a good example. Congenital, inflammatory, traumatic, and deteriorating lung lesions frequently present problems with an associated cardiopulmonary-reserve deficit. The success or failure of management of the patient's primary lesion may depend considerably on the recognition and understanding of their pulmonary deficiency. Fortunately, improved, accurate methods of study are now available for determining the status of cardiopulmonary function. This paper deals with several of these problems, how they may be analyzed, and possible methods of management. <h3>Total Atelectasis of One Lung</h3> Inflammatory disease such as tuberculosis of the lung and traumatic injuries of the chest may lead to complete stenosis of a primary bronchus with total atelectasis of an entire lung. This produces marked reduction in pulmonary capacity and,
Plastic Surgery
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Achalasia of the esophagus. Diagnosis and treatment
Authors: J. S. Schroder
Journal: JAMA (1967)

Achalasia of the esophagus is characterized by lack of neuromuscular coordination, which results in an absence of normal peristalsis in the body of the esophagus and a failure of relaxation of the lower segment. It is a frequent cause of esophageal obstruction. Symptoms of achalasia include dysphagia, regurgitation (nocturnal overflow), substernal discomfort, recurrent pulmonary infection, and weight loss. The diagnosis of achalasia is established by esophagoscopy, x-ray examinations (routine posterioanterior and lateral views), barium swallow and cinefluoroscopy, and esophageal motility studies. Treatment consists of bougienage, forceful dilation, and Heller esophagocardiomyotomy.