tbuckley/cabot-search huggingface dataset:
2. Nonsurgical Prophylaxis
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tolmetin
Authors: Sheila Moriber Katz
Journal: JAMA (1981)

FENOPROFEN calcium and naproxen, nonsteroidal anti-inflammatory agents derived from proprionic acid, are linked to nephrotic syndrome, reversible renal failure, and acute interstitial nephritis.<sup>1,2</sup>We present here a case of reversible renal failure and acute interstitial nephritis in a patient treated with tolmetin sodium (Tolectin), a nonsteroidal anti-inflammatory agent. <h3>Report of a Case</h3> A 70-year-old woman was admitted to the hospital because of nausea, anorexia, muscle weakness, and decreased urine output of two weeks' duration. She had mild hypertension for 30 years and mild osteoarthritis for ten years. Medications were as follows: methyldopa-hydrochlorothiazide (Aldoril), 25 mg three times a day for 15 years, prazosin hydrochloride (Minipress), 1 mg twice a day for two years, and tolmetin sodium, 200 mg three times to four times a day for three months. Physical examination on admission showed blood pressure to be 150/90 mm Hg. Heart rate was regular at 80 beats per minute.
Methods in Medicine. The Manual of the Medical Service of George Dock, M.D., Sc.D.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomized, placebo-controlled, double-blind phase 2 trial of peri-operative cimetidine (CIM) in early colorectal cancer (CRC).
Authors: Michael B. Jameson, Michael P. N. Findlay, Ian Bissett, Simione Lolohea, Judith Warren, Frank Frizelle, John Keating, Gregory M Jacobson, Michael Arendse, Claudia Romano, Ralph van Dalen
Journal: Journal of Clinical Oncology (2015)

e14598 Background: Perioperative CIM reduced mortality (HR 0.53, 95% CI 0.32-0.87) with curative-intent surgery for CRC in a Cochrane meta-analysis of 5 randomised phase 2 trials. The benefit was greatest in patients (pts) whose tumours expressed the sialyl Lewis (sLe) antigens A (CA19-9) or X that bind to endothelial cells via E-selectin, which is induced by inflammatory cytokines and inhibited by CIM. This randomised trial evaluated issues critical to planning a phase 3 trial. Methods: Pts with stage 1-3 CRC were randomised to take cimetidine 800mg BID or placebo orally for 5 weeks, starting 2-7 days before curative-intent surgery. The primary endpoint was 2-year disease-free survival (DFS) in pts with sLe antigen-positive tumours; secondary endpoints include survival, CIM compliance, recruitment, serum inflammatory cytokine profile and tumour expression of sLe antigens by IHC. Results: 128 pts (35% female), median 70 (range 29-86) years, were recruited in 4 centres over 3.5 years and randomised to CIM (65) or placebo (63); 6 pts took none. 40% of screened CRC pts were eligible and 53% offered the study were recruited. Of the 45% with a rectal primary, 68% received preoperative chemoradiation (CRT); 15% and 21% of those were downstaged to TNM stage 0 or 1 respectively. Postoperative TNM stage was 0-1, 2, 3 and 4 in 27%, 38%, 31%, and 2% respectively. 77% of pts took > 80% of planned study medication orally in the first 2 postoperative days. 29% of pts had adjuvant chemotherapy. At median follow-up of 26 (range 5-56) months, with 18 relapses and 15 deaths, 2-year DFS was 89% and 83% with CIM and placebo respectively (HR 0.76, logrank p = 0.56). Serum inflammatory cytokines were variably elevated up to 2 weeks post-operatively but normalised by 4 weeks. All tumours expressed at least one sLe antigen in > 5% of cells; 32% expressed at least one of them in > 70% of cells but DFS in this cohort was similar to the whole group. Tumour IHC score for CA19-9 correlated with baseline serum CA19-9 (r = 0.30, p = 0.014). Conclusions: Perioperative CIM for 5 weeks is feasible and covers the duration of elevated inflammatory cytokines. A trend to improved DFS is consistent with meta-analysis data and a phase 3 trial is justified. Clinical trial information: ANZCTR12609000769280.
SAT-034-The psychomotor vigilance task: Role in the diagnosis of hepatic encephalopathy and relationship with driving ability
Authors: Chiara Formentin, Michele De Rui, Mirko Zoncapè, Silvia Ceccato, Lisa Zarantonello, Marco Senzolo, Patrizia Burra, Paolo Angeli, Piero Amodio, Sara Montagnese
Journal: Journal of Hepatology (2019)
INTESTINAL ANTISEPSIS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reporting suspected child abuse
Authors: M. A. Reinhart
Journal: JAMA (1983)

<h3>To the Editor.—</h3> I read the informative and erudite article on Sir Thomas Browne (1982;248:1845) by John H. Dirckx, MD, noting the 300th anniversary of Browne's death and observing, among other assessments, that his<i>Religio Medici</i>and<i>Christian Morals</i>were not in any sense scientific works. <i>Religio Medici</i>transcends dimensions of a religious, spiritual, philosophical, and literary work. I believe it can be viewed, with<i>A Letter to A Friend</i>and<i>Christian Morals</i>, at least in part, as psychological in the modern sense when studied from the vantage point of contemporary psychiatric knowledge and concepts. Discerning insights into psychological experience and functioning and awareness about mental derangements appear clearly. The variety of psychodynamics of which Browne was cognizant and wrote would, in 20th-century terms, be designated compensation, repression, reaction formation, identification, introjection, rationalization, and displacement. He was certainly aware of unconscious components in human behavior and deserves a niche in
Resident Forum
Authors: Naakesh A. Dewan
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUBCUTANEOUS INJURIES OF SOFT PARTS.
Authors: JOHN EDDY LUCKEY
Journal: JAMA (1898)

<h3>SUBCUTANEOUS INJURIES OF THE ABDOMINAL ORGANS.</h3> <i>The stomach</i>, when of normal size and in its proper position, is so well protected that it is seldom injured by non-penetrating forces. Contusions, laceration or complete rupture may result from a blow or kick, administered over the organ, when in a state of partial or complete distention. Violent emesis has caused rupture of the stomach in cases already weakened by constitutional or local disease. In O'Farrell's<sup>14</sup>case violent vomiting, during fever, caused a rupture of the posterior wall three inches long. Owing to the greater thickness of its walls and its better protection, the stomach is less frequently the subject of rupture than is the intestine. Other viscera are generally involved and the injury is, as a rule, fatal. The seat of the rupture is usually near the pylorus, or greater curvature, though it may be in any part. Morris's<sup>15</sup>case
Substance Abuse
Authors: Robert L. DuPont
Journal: JAMA (1986)

Recent advances in the understanding of anxiety and drug abuse have cast new light on the controversy about dependence on antianxiety medications in clinical practice. Epidemiologic data gathered over the last 15 years show that US benzodiazepine use is not higher than that of other developed nations and that most patients who use these drugs do so with both symptomatic relief and restraint in terms of amount, dose, and duration of treatment.<sup>1</sup>On the other hand, these same data show that almost 2% of the adult population use these agents more or less chronically. The last decade has seen remarkable changes in our understanding of anxiety disorders. It was once thought that anyone who was "nervous" or "tense" was more or less like everyone else, except perhaps that they were more sensitive to unpleasant feelings. It is now clear that pathological anxiety affects a minority of the population, strongly
Temozolomide in Combination With Docetaxel in Patients With Advanced Melanoma: A Phase II Study of the Hellenic Cooperative Oncology Group
Authors: D. Bafaloukos, H. Gogas, V. Georgoulias, E. Briassoulis, G. Fountzilas, E. Samantas, Ch. Kalofonos, D. Skarlos, A. Karabelis, P. Kosmidis
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Temozolomide is a novel oral alkylating agent that is effective against melanoma. Moreover, temozolomide readily crosses the blood-brain barrier and may consequently be effective in patients with brain metastases. This phase II study was performed to assess the efficacy and safety of the combination regimen of temozolomide and docetaxel in patients with advanced metastatic melanoma. PATIENTS AND METHODS: Sixty-five patients with metastatic melanoma were enrolled. Treatment consisted of intravenous docetaxel (80 mg/m 2 ) on day 1 and oral temozolomide (150 mg/m 2 ) on days 1 to 5, every 4 weeks, for a maximum of six cycles. RESULTS: Sixty-two patients were eligible for the efficacy and safety analysis. Seventeen patients (27%) achieved an objective response, including five complete (8%) and 12 partial responses (19%). Median response duration was 9.5 months. Among responders, median time to progression (TTP) was 11.2 months and median overall survival (OS) was 16 months. For all treated patients, the median TTP was 4 months and median OS was 11 months. Three (38%) of eight patients who presented with brain metastases had a partial response for 5, 6, and 12 months. Of 52 patients who did not have brain involvement at presentation, only four (8%) developed brain metastases at a median follow-up of 14 months. Myelosuppression was the primary toxicity. CONCLUSION: The combination of temozolomide and docetaxel was effective and well tolerated as first-line treatment for patients with advanced metastatic melanoma and demonstrated encouraging antitumor activity against brain metastases.
Medical care in the streets
Authors: N. L. Caroline
Journal: JAMA (1977)

AN EMERGENCY medical services delivery system is as strong as its weakest link.<sup>1,2</sup>As data on acute myocardial infarction and multiple trauma have been accumulated over the past several years, it has become clear that a considerable portion of morbidity and mortality occurs outside the hospital, before the patient reaches medical care.<sup>3</sup>It has similarly become clear that implementation of high standards of advanced prehospital life support—at the scene and in transport—can improve the outcome of critically ill and injured patients, thus reducing the need for prolonged, often futile, terminal intensive care. Because of increasing awareness of these facts, the past several years have seen a burgeoning of paramedicstaffed mobile intensive care units (MICUs), equipped to deliver sophisticated medical care on the scene for a variety of medical and surgical emergencies. Advanced emergency medical technicians, or paramedics, are trained in arrhythmia recognition, administration of medications, intravenous infusion, endotracheal
Subcellular distribution of large and small hepatitis delta antigen in hepatocytes of hepatitis delta virus superinfected woodchucks
Authors: John M. Cullen, Caroline David, Jia-Gang Wang, Paul Becherer, Stanley M. Lemon
Journal: Hepatology (1995)

Hepatitis delta virus (HDV) encodes only a single protein, the hepatitis delta antigen (HDAg), which is expressed as two molecular forms (large and small) with different functions in viral replication. Compared with small antigen, large antigen has a 19 residue carboxyl terminal extension. Antibodies that recognize a large antigen-specific epitope within this carboxyl extension, or an epitope shared by both large and small antigens (total antigen), were used in immunohistochemical studies of liver sections from superinfected woodchuck carriers of woodchuck hepatitis virus. There were no differences in the subcellular distributions of large and total antigens, with both generally present only in nuclei of hepatocytes. Rare cells demonstrated cytoplasmic staining. Complete or partial granular nucleoplasmic staining with stained nucleoli was the most common pattern observed. Within 31 days of infection, 0.1% to 19% (mean = 7.4%) of all hepatocytes contained antigen. The proportion of these nuclei containing large antigen ranged from 0 to 100% (mean, 39%), and increased during the first month of infection. The number of antigen-positive nuclei and the proportion staining for large antigen were reduced with progression to chronicity, correlating with reductions in the level of viremia. Thus, the large hepatitis delta antigen shares a common subcellular distribution with small antigen and is found in an increasing proportion of the nuclei of infected cells during the course of acute infection. (Hepatology 1995; 22:1090-1100.).
THE NURSE'S RESPONSIBILITY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intractable Rheumatoid Arthritis
Authors: Daniel J. McCarty
Journal: JAMA (1982)

Seventeen patients (15 women, two men) with progressive, erosive seropositive rheumatoid arthritis (RA) refractory to conventional therapy were treated with cyclophosphamide, azathioprine, and hydroxychloroquine sulfate for an average of 27 ± 19 months (x̄±SD throughout) (range, five to 60 months). Disease suppression began in 14 patients within three to 16 months (mean, seven months). Five patients achieved complete remission, two had activity in a single joint only, seven had partial disease suppression, and three showed no response. Prednisone dosage was decreased or administration discontinued in nine of ten patients (5.8 ±1.2 to 2.7 ±3 mg/day). Serial hand roentgenograms showed recortication of erosions in nine patients, with "filling in" of some erosions in three of these. No change was seen in the roentgenograms of five patients, while progressive disease occurred in three instances. Combined therapy with small doses of three drugs, each with proved antirheumatic activity when used separately in larger doses, may provide satisfactory long-term disease control in patients with intractable RA. This regimen is experimental. Proof of efficacy requires a controlled study. Until such data are obtained, this drug combination is not recommended for general use. (<i>JAMA</i>1982;248:1718-1723)
Treatment of pump failure in acute myocardial infarction
Authors: H. S. Loeb
Journal: JAMA (1981)

SOME degree of cardiac insufficiency occurs in most patients with acute myocardial infarction (MI), but in many, there are no important clinical consequences and therapy may be more harmful than useful. It is the patients whose clinical condition dictates the need for some therapeutic hemodynamic intervention with which this article will deal. <h3>Hemodynamic Monitoring</h3> Because MI usually involves the left ventricle, the early clinical manifestations of heart failure are usually those associated with either impaired oxygenation of the arterial blood owing to pulmonary congestion or inadequate peripheral perfusion owing to reduced cardiac output. Cardiogenic shock is an extreme example of both. Although cardiac failure can be recognized at the bedside, misinterpretation of clinical signs is not uncommon, particularly in patients with preexisting lung disease. Likewise, although it is usually possible to recognize inadequate peripheral perfusion at the bedside, the clinical findings associated with reduced cardiac output are not reliable in
Multiphasic Screening
Authors: Suzanne W. Fletcher
Journal: JAMA (1977)

Multiphasic screening as a case-finding tool was evaluated in a randomized, controlled study. For each of 112 physicians, a patient was assigned to one of three groups: multiphasic screening group (SG), chart abstract group (AG), or chart review group (RG). Medical problem lists constructed before and after receiving additional information were compared. Physicians for 36 SG patients identified considerably more new medical problems, both total (77) and ones they considered important (25), than 40 AG physicians (14 and 8) and 36 RG physicians (4 and 0). One year later, 38 of the 95 newly identified problems had been acted on, 31 in the SG. Medical care was affected in nine patients: six in SG, two in AG, and one in RG. Multiphasic screening may help physicians identify new medical problems in clinic patients. (<i>JAMA</i>237:887-891, 1977)
Transmission of Hepatitis C Virus Infection Associated With Home Infusion Therapy for Hemophilia
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal