tbuckley/cabot-search huggingface dataset:
The Healthy Baby.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
成年异位性皮炎患者中的五种患者报告结果的严重性等级
Authors: P.P. Vakharia, R. Chopra, R. Sacotte, N. Patel, S. Immaneni, T. White, R. Kantor, D.Y. Hsu, E.L. Simpson, J.I. Silverberg
Journal: British Journal of Dermatology (2018)

Summary 异位性皮炎是一种皮肤病(AD,通常简称为湿疹),可能导致发痒(瘙痒)、睡眠障碍和生活质量(QoL)受损,通常会影响学习和工作等日常活动,进而影响心理健康。在研究湿疹或治疗患者期间,医生通常会使用各种系统来记录患者的湿疹严重程度。一些系统注重于患者的体征,例如皮肤损害的严重程度(受影响皮肤的面积)如何。然而,如上所述,这种疾病的许多症状是无法通过观察皮肤来衡量的,因此需要使用“患者报告结果”(PRO)的不同衡量方法,在这些方法中,患者会回答有关生活质量、情绪或瘙痒严重程度等问题。这些衡量方法并不专门用于湿疹,也可用于一系列皮肤疾病。每种PRO都对应着一系列不同的问题、反应选项和打分系统,因此难以针对不同的PRO来说明结果。业界针对一些PRO制定了严重性等级,用结果的分数来表示严重性级别,例如,在一项称为POEM的PRO中,0至7分表示轻度、8至16分表示中度,而17至28分则表示重度。本研究旨在确认针对先前报告的称为POEM和DLQI的PRO的等级对成年AD患者来说是否确实准确。此外,研究人员还针对一些其他的PRO制定了严重性等级:NRS-瘙痒,平均ItchyQOL和5-D瘙痒程度。作者们确认,POEM和DLQI的现有等级对成年AD患者来说运用得当,并建议修正某些其他PRO的等级并制定新等级。
Hepatic lipid peroxidation in patients with hereditary hemochromatosis Departments of 1Clinical Chemistry and 2Anatomy, University of Oulu, Finland, 3Division of Gastroenterology and Hepatology, 4Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO
Journal: Hepatology (1995)

Pathophysiological mechanisms for hepatocellular injury, fibrosis and/or cirrhosis in hepatic iron overload are poorly understood. An increase in intracellular transit pool of iron can catalyze peroxidation of lipids to produce reactive aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (HNE). Covalent binding of such lipid aldehydes with proteins may cause impairment in cellular function and integrity. This investigation was focused on quantitative determination of MDA and HNE-protein adducts, and to establish a correlation between iron deposition and formation and localization of MDA and HNE-protein adducts, using immunohistochemistry. To achieve iron overload, male SD rats were fed a 2.5% carbonyl iron-supplemented diet for six weeks, while control animals received standard diet. Total iron as well as low molecular weight chelatable iron (LMWC-Fe) in the hepatic tissue of rats fed the iron supplemented diet increased significantly (∼14- and ∼15-fold, respectively). Quantitative ELISA for MDA-and HNE-protein adducts showed remarkable increases of 186 and 149%, respectively, in the liver homogenates of rats fed the iron-supplemented diet. Sections of liver stained for iron showed striking iron deposits in periportal (zone 1) hepatocytes, which was less dramatic in midzonal (zone 2) cells. Livers from iron-loaded rats showed strong, diffuse staining for both MDA and HNE adducts, which was highly pronounced in centrilobular (zone 3) hepatocytes, but was also evident in midzonal cells (zone 2). The demonstration of greater formation of both MDA and HNE-protein adducts provides evidence of iron-catalyzed lipid peroxidation in vivo. Although in this model of iron overload there was no evidence of tissue injury, our results provide an account of some of the initiating factors or early molecular events in hepatocellular damage that may lead to the pathological manifestations seen in chronic iron overload.
Clinical and Operative Gynæcology.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In vivo transduction of hematopoietic stem cells after neonatal intravenous injection of an amphotropic retroviral vector in mice
Authors: L XU
Journal: Molecular Therapy (2004)

Hematopoietic stem cells (HSC) are important targets for gene therapy. Most protocols involve ex vivo modification, in which HSC are transduced in vitro and injected into the recipient. An in vivo delivery method might simplify HSC gene therapy. We previously demonstrated that iv injection of an amphotropic retroviral vector (RV) into newborn mice resulted in long-term expression from hepatocytes. The goal of this study was to determine if HSC were also transduced. After neonatal administration of 1 × 1010 transducing units/kg of RV, peripheral blood cells had ∼0.1 copy of RV per cell for up to 22 months. At 18 months, RV sequences were detected in T, B, and myeloid cells from bone marrow (BM). Unfractionated BM was transplanted into naive recipients after total body irradiation. Recipients maintained similar levels of the RV in their blood cells for 10 months, at which time RV sequences were present at the same integration site in all lineages of cells from BM. We conclude that neonatal iv injection of RV results in transduction of HSC in mice, which might be used for BM-directed gene therapy. Transduction of blood cells after liver-directed neonatal gene therapy might have adverse effects in patients, although no leukemias developed here.
Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease
Authors: M. G. Seneff
Journal: JAMA (1995)

<h3>Objective.</h3> —To describe outcomes and identify variables associated with hospital and 1-year survival for patients admitted to an intensive care unit (ICU) with an acute exacerbation of chronic obstructive pulmonary disease (COPD). <h3>Design.</h3> —Prospective, multicenter, inception cohort study. <h3>Setting.</h3> —Forty-two ICUs at 40 US hospitals. <h3>Patients.</h3> —A total of 362 admissions for COPD exacerbation selected from the Acute Physiology and Chronic Health Evaluation (APACHE) III database of 17440 ICU admissions. <h3>Measurements and Results.</h3> —Hospital mortality for the 362 admissions was 24%. For the 167 patients aged 65 years or older, mortality was 30% at hospital discharge, 41% at 90 days, 47% at 180 days, and 59% at 1 year. Median survival for all patients was 224 days, and median survival for the patients who died within 1 year was 30.5 days. On multiple regression analysis, variables associated with hospital mortality included age, severity of respiratory and nonrespiratory organ system dysfunction, and hospital length of stay before ICU admission. Development of nonrespiratory organ system dysfunction was the major predictor of hospital mortality (60% of total explanatory power) and 180-day outcomes (54% of explanatory power). Respiratory physiological variables (respiratory rate, serum pH, Paco<sub>2</sub>, Pao<sub>2</sub>, and alveolar-arterial difference in partial pressure of oxygen [Pao<sub>2</sub>—Pao<sub>2</sub>]) indicative of advanced dysfunction were more strongly associated with 180-day mortality rates (22% of explanatory power) than hospital death rates (4% of explanatory power). After controlling for severity of illness, mechanical ventilation at ICU admission was not associated with either hospital mortality or subsequent survival. <h3>Conclusions.</h3> —Patients with COPD admitted to an ICU for an acute exacerbation have a substantial hospital mortality (24%). For patients aged 65 years or older, mortality doubles in 1 year from 30% to 59%. Hospital and longer-term mortality is closely associated with development of nonrespiratory organ system dysfunction; severity of the underlying respiratory function substantially influences mortality following hospital discharge. The need for mechanical ventilation at ICU admission did not influence either short- or long-term outcomes. Physicians should be aware of these relationships when making treatment decisions or evaluating new therapies. (<i>JAMA</i>. 1995;274:1852-1857)
ORIGINAL ARTICLES.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Statement on use of apolipoprotein E testing for Alzheimer disease. American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer disease
Authors: Lindsay A. Farrer, Mitchell F. Brin, Louis Elsas, Alison Goate, James Kennedy, Richard Mayeux, Richard H. Myers, Philip Reilly, Neil J. Risch
Journal: JAMA (1995)

To evaluate the published data on the association between apolipoprotein E genotype (APOE) and Alzheimer disease (AD) and determine whether the data support the use of genetic testing for diagnosis or prediction of disease. This statement is intended for neurologists, psychiatrists, geneticists, primary care providers, diagnostic laboratories, and the public.The joint American College of Medical Genetics (ACMG) and American Society of Human Genetics (ASHG) Test and Technology Transfer Committee developed a 10-member ACMG/ASHG Working Group to assess available data on the association of AD with APOE alleles. To ensure inclusion of clinical specialists primarily involved with AD patients and families, the American Academy of Neurology (AAN) and the American Psychiatric Association (APA) appointed liaisons to the Working Group.Peer-reviewed journal publications obtained from an Index Medicus search or known to members of the Working Group were the source of data on which the statement is based.Following discussions with all members of the Working Group, a draft statement was prepared by the chair and circulated among all members until a consensus was reached. The consensus draft was sequentially reviewed and endorsed by the appropriate scientific and executive committees of the ACMG, ASHG, AAN, APA, and the National Institutes of Health-Department of Education Working Group on Ethical, Legal, and Social Implications of Human Genome Research. In some instances, suggestions from these committees were incorporated into the final statement.There is general consensus that APOE epsilon 4 is strongly associated with AD and that when present may represent an important risk factor for the disease. However, at the present time it is not recommended for use in routine clinical diagnosis nor should it be used for predictive testing. Studies to date indicate that the APOE genotype alone does not provide sufficient sensitivity or specificity to allow genotyping to be used as a diagnostic test. Because AD develops in the absence of APOE epsilon 4 and because many with APOE epsilon 4 seem to escape disease, genotyping is also not recommended for use as a predictive genetic test. The results of a collaborative study under way will clarify some of these issues. Whether APOE genotypes have other uses in the management of AD will become apparent over the next few years.
First complex disasters symposium features dramatically timely topics
Authors: A. Skolnick
Journal: JAMA (1995)

IT SEEMS tragically prophetic that the first Harvard University Symposium on Complex Disasters was held only 9 days before a terrorist's bomb smashed the federal office building in Oklahoma City, killing 168 men, women, and children and sending psychological shock waves throughout the nation. The bombing and its aftermath illustrate many of the issues discussed at the 2-day conference, which explored ways of meeting the complex medical, public health, psychological, and logistical challenges that follow natural and man-made disasters. The symposium, held in Boston, Mass, and sponsored by Harvard Medical School, Harvard School of Public Health, and the Harvard Forum on Disasters, brought together an interdisciplinary group of experts to examine the ethical and logistical problems that follow disasters—from hurricanes to major airplane crashes, earthquakes to civil wars, floods to acts of terrorism. Among the subjects discussed were ways of improving policy planning for disaster management, handling the logistics of
Distribution of Blood Lead Levels in a Birth Cohort of New Zealanders at Age 21
Authors: J. Paul Fawcett, Sheila M. Williams, John L. Heydon, Trevor A. Walmsley, David B. Menkes
Journal: Environmental Health Perspectives (1996)

Little is known about lead exposure in the general population of young adults. In this study, whole blood lead concentration (PbB) was determined in a sample of the Dunedin Multidisciplinary Health and Development Study, a well-documented birth cohort of New Zealanders aged 21 years in 1993-1994. PbB in those who consented to venipuncture at 21 years of age (n = 779; 411 males, 368 females) was compared to PbB for the same cohort at age 11 years. The PbB at age 21 ranged from 0.4 to 56 micrograms/dl with a geometric mean of 4.5 micrograms/dl (95% CI, 4.3-4.7 micrograms/dl). Only three individuals had a PbB above 30 micrograms/dl. Males had significantly higher PbB than females (geometric mean 6.0 vs. 3.2 micrograms/dl; p < 0.0001). The PbB at age 21 was 53% lower than in the same individuals at age 11 (geometric mean 4.8 vs. 10.2 micrograms/dl; p < 0.001; n = 480) and the correlation between corresponding values was weak (r = 0.19; p < 0.001). PbB at age 21 showed significant associations with high risk occupational activities, recreational exposure, domicile close to a main road, smoking, and male sex. Blood lead concentrations continue to fall in New Zealand, but occupational and recreational activities remain a significant source of lead exposure.
Gastric Phytobezoar
Authors: Harold M. Bruck
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The use of endoscopy in the dissolution of gastric phytobezoar (229:1332, 1974) is elegant, but perhaps should be reserved until orally administered enzymes have been tried. The efficacy of cellulase in dissolving phytobezoar was reported by Pollard and Block<sup>1</sup>and confirmed by Deal et al.<sup>2</sup> I encountered a case of phytobezoar in a 56-year-old man with subtotal gastrectomy (Billroth I) nine months following vagectomy for marginal ulcer. His history included ingestion of three oranges per day for several months. On the basis of Pollard's protocol, the patient was given a five-day course of three pulverized Gastroenterase tablets (containing pepsin, pancreatic enzyme concentrate, cellulase, and dehydrocholic acid) after each meal, which he took as an outpatient. An upper gastrointestinal roentgenographic series immediately thereafter showed complete disappearance of the bezoar. This case supports the use of orally administered chemicals for bezoar and recommends it as a noninvasive,
Abstract 14071: <i>In-vivo</i> Assessment of the Peri-infarcted Region by a Novel Micro-electrode Array System in a Large Animal Model of Myocardial Infarction
Authors: Tobias Plenge, Maria Guschlbauer, Alexandra Maul, Marcel Halbach, Benjamin Krausgrill, Anja Sterner-Kock, Daniel Stevens, Stephan Baldus, Dennis Ladage
Journal: Circulation (2015)

Introduction: Ventricular arrhythmias are life threatening complications in ischemic cardiomyopathy associated with significant mortality. Inhomogeneity in conduction and dispersion of refractoriness are substrates for reentry tachycardias. Micro-electrode array (MEA) systems are currently used to study extracellular field potentials of myocytes in vitro. Hypothesis: Aim of this study was to validate and apply for the first time a novel epicardial MEA 128-channel electrode in a large animal model of myocardial infarction (MI). Methods: We induced MI by percutaneous coil occlusion of the proximal LAD in swine (body weight: 20±1.5 kg, n=6). Epicardial mapping in-vivo was performed by a lateral mini thoracotomy (length 5 cm) with placement of a flexible 128-channel-MEA (32x32 mm, 100 μm electrodes with 2.7 mm distance) on (a) healthy, (b) infarcted and (c) peri-infarcted areas of the left ventricle. Animals were stimulated with predefined pacing protocols. Results: We assed global as well as regional function after MI confirming its efficacy and impact. Application of the MEA - electrode was safe and feasible, showing reproducible results in all animals. Analyzing different ventricular regions in 2D- reconstruction maps we found the inhomogeneity of conduction velocity to be significantly increased creating a characteristic pattern in the peri-infarcted region ( Figure A ). At each electrode the local ECG was registered to calculate differences in activation time. In comparison to recordings prior to the MI the peri-infarct tissue exhibited significant aberrations in spontaneous impulse propagation ( Figure B ) as well as in pacing protocol measurements. Conclusions: We applied and demonstrated the feasibility of in-vivo epicardial MEA - mapping in a swine large animal model of MI. We believe this tool holds great potential for evaluating conduction velocity and impulse propagation for testing regenerative and anti-arrhythmic therapeutic strategies.
Section 15.—Polymyalgia Rheumatica
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exercise—A Diagnostic Virtuoso
Authors: Samuel Vaisrub
Journal: JAMA (1979)

Physical exercise—be it for therapeutic reasons, or sport, or simply for the fun of it—is also an exercise in diagnosis. By observing the limits of their exercise tolerance, exercisers monitor their endurance and diagnose their fitness or its shortcomings. Exercise became a diagnostic tool formally when physicians began to measure its effect on the pulse rate and blood pressure. As a rough guide to cardiac performance, these measurements proved clinically useful. More refined measurements of the effect of exercise on oxygen consumption and on other biochemical and hemodynamic parameters have further enhanced its value in diagnosis. With the advent of electrocardiography, exercise rose to even greater prominence. The Master two-step exercise test gave it an almost decisive voice in the diagnosis of ischemic heart disease. When the test proved wanting in specificity and sensitivity, the treadmill and bicycle ergometer largely replaced it. These sophisticated modifications, however, also appear to be
Maturing Thoughts on Ventricular Premature Beats
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clarification of False-Positive Reporting Language in an Original Investigation
Authors: Maria Yialamas
Journal: JAMA Internal Medicine (2020)

Linda S. Kinsinger, MD, MPH; Charles Anderson, MD, PhD; Jane Kim, MD, MPH; Martha Larson, BSN, MS; Stephanie H. Chan, MPH; Heather A. King, PhD; Kathryn L. Rice, MD; Christopher G. Slatore, MD, MS; Nichole T. Tanner, MD, MSCR; Kathleen Pittman, BSN, MPH; Robert J. Monte, MBA; Rebecca B. McNeil, PhD; Janet M. Grubber, MSPH; Michael J. Kelley, MD; Dawn Provenzale, MD, MSc; Santanu K. Datta, PhD; Nina S. Sperber, PhD; Lottie K. Barnes, MPH; David H. Abbott, MS; Kellie J. Sims, PhD, MS; Richard L. Whitley, BS; R. Ryanne Wu, MD, MHS; George L. Jackson, PhD, MHA