tbuckley/cabot-search huggingface dataset:
In Reply
Authors: David A. Reardon
Journal: Journal of Clinical Oncology (2009)

On behalf of my coauthors, I wish to thank Chamberlain 1 for the important issues he raised regarding our recently reported trial, 2 in which patients with glioblastoma (GBM) were randomly assigned at first recurrence to receive single-agent cilengitide, an ␣ v ␤ 3 /␣ v ␤ 5 integrin inhibitor, at either 500 mg or 2,000 mg twice weekly.The first important question raised by Chamberlain was why we chose to design our study to evaluate outcome against that reported with temozolomide, 3 rather than outcomes reported in a series of salvage phase II studies. 4,5We chose the comparative benchmark achieved with temozolomide for two reasons.First, a more favorable outcome was achieved in the temozolomide study, thus setting a higher bar of comparison.Second, our study, like the temozolomide study, was limited to patients with GBM at first recurrence, in contrast to the series of phase II studies suggested by Chamberlain, which included patients with disease that had progressed beyond first recurrence.Chamberlain also questioned whether our study 2 had achieved sufficiently positive results to justify additional evaluation of cilengitide as treatment for patients with recurrent GBM.Unfortunately, our study was not designed to define outcome relative to an established salvage regimen.Nonetheless, we did observe encouraging evidence of antitumor activity, particularly among patients treated at the cilengitide dose level of 2,000 mg.In these patients, we noted a radiographic response rate and median overall survival that surpassed those achieved with temozolomide, and a 6-month progression-free survival rate that was within the 95% CI achieved with temozolomide. 3In addition, we feel that these results have additional significance because they were achieved in patients who had progressive disease after receiving temozolomide therapy.Finally, Chamberlain questioned the impact of bevacizumab therapy and methylguanine methyltransferase (MGMT) status on outcome in patients treated on our study. 2Regarding the former, none of the patients treated on our study received bevacizumab therapy.Second, MGMT status was not assessed, because our study was conducted before the link between response to cilengitide therapy and MGMT status had been reported. 6Nonetheless, we agree with Chamberlain that in future cilengitide studies, both bevacizumab therapy and MGMT status will need to be considered in the interpretation of overall study results.
Firearms and Fatalities
Authors: John Scott Ferguson
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The highly charged political debate over firearms and violence in America continues. As noted by Teret,<sup>1</sup>there is little agreement about specific actions necessary to reduce violence in America, but there appears to be some agreement that more data are needed. The Fatal Accident Reporting System (FARS) has been proposed as a model for data collection.<sup>2</sup>During this controversial debate, it is especially important for health care professionals to discuss what can reasonably be concluded from proposed data collection and to carefully consider such data prior to making recommendations. Since most automobile-related deaths are unintentional and most firearm-related deaths are intentional, it is likely that the 2 situations will be different. The interesting data in the article by Dr Hargarten and colleagues<sup>3</sup>fall short of supporting some of the authors' conclusions. Table 2 clearly shows that the most common firearm caliber associated with gun
The Biological Effects of Some Podophyllin Compounds and Their Dependence on Chemical Structure
Authors: V. Seidlová-Mašínová, J. Malinský, F. Šantavý
Journal: JNCI Journal of the National Cancer Institute (1957)

The Biological Effects of Some Podophyllin Compounds and Their Dependence on Chemical Structure Get access V. Seidlová-Mašínová, V. Seidlová-Mašínová Chemical Institute and Histological Institute of the Medical Faculty, Palacký University, Olomouc, Czechoslovakia Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Malinský, J. Malinský Chemical Institute and Histological Institute of the Medical Faculty, Palacký University, Olomouc, Czechoslovakia Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Šantavý F. Šantavý Chemical Institute and Histological Institute of the Medical Faculty, Palacký University, Olomouc, Czechoslovakia Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 3, March 1957, Pages 359–371, https://doi.org/10.1093/jnci/18.3.359 Published: 01 March 1957 Article history Received: 26 September 1956 Published: 01 March 1957
Medical Mycology: The Pathogenic Fungi and the Pathogenic Actinomycetes
Authors: Donald G. Ahearn
Journal: JAMA (1982)

<i>Medical Mycology</i>, by John Williard Rippon, PhD, is an extensive (842 pages, 8″X11″ pagination) review of medical mycology. No specialist or college library should lack this comprehensive volume. The book is well illustrated with line drawings, numerous excellent photographs of microstructures, colony characteristics, and ultrastructures, with photographs of the classic overt manifestations of disease and microscopic pathology. The utilitarian nature of the text is enhanced by chapters reviewing the classification of the fungi, allergic and toxic diseases associated with fungi, pharmacology of antimycotic drugs, the identification of common laboratory contaminants, and a detailed presentation on culture methods, media, stains, and serological procedures. The book is well suited for use as a textbook for a semester course for the advanced student. Moreover, the extensive list of selected historical and recent references presented in a complete format for each chapter makes the volume an important reference work for the specialist. Although the
Commentaire de travail de S. Pungpapong et al., pp. 673
Journal: Endoscopy (2007)

See also: Accuracy and interobserver agreement of small-caliber vs. conventional esophagogastroduodenoscopy for evaluating esophageal varicesEndoscopy 2007; 39(08): 673-680DOI: 10.1055/s-2007-966351
"Breathing Machines" and Their Use in Treatment: Report of the Respirators (Poliomyelitis) Committee
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Breast-feeding
Authors: L. M. M. Beadnell
Journal: BMJ (1942)

<h3>Abstract</h3> <h3>Background</h3> Major depressive disorder (MDD) is characterized by elevated activity of peripheral neuro-immune and neuro-oxidative pathways, which may cause neuro-affective toxicity by disrupting neuronal circuits in the brain. No study has explored peripheral indicators of neuroaxis damage in MDD in relation to serum inflammatory and insulin resistance (IR) biomarkers, calcium, and the physio-affective phenome consisting of depressive, anxious, chronic fatigue, and physiosomatic symptoms. <h3>Methods</h3> Serum levels of phosphorylated tau protein 217 (P-tau217), platelet-derived growth factor receptor beta (PDGFR), neurofilament light chain (NF-L), glial fibrillary acidic protein (GFAP), C-reactive protein (CRP), calcium and the HOMA2-insulin resistance (IR) index were measured in 94 MDD patients and 47 controls. <h3>Results</h3> 61.1% of the variance in the physio-affective phenome (conceptualized as a factor extracted from depression, anxiety, fatigue and physiosomatic symptoms) is explained by the regression on GFAP, NF-L, P-tau2017, PDGFRβ and HOMA2-IR (all positively associated), and decreased calcium. In addition, CRP and HOMA2-IR predicted 28.9% of the variance in the neuroaxis index. We observed significant indirect effects of CRP and calcium on the physio-affective phenome which were partly mediated by the four neuroaxis biomarkers. Annotation and enrichment analysis revealed that the enlarged GFAP, P-tau217, PDGFR, and NF-L network was enriched in glial cell and neuronal projections, the cytoskeleton and axonal transport, including a mitochondrion. <h3>Conclusions</h3> Peripheral inflammation and IR may damage the astroglial and neuronal projections thereby interfering with mitochondrial transport. This toxicity, combined with inflammation, IR and lowered calcium, may, at least in part, induce the phenome of MDD.
Le dolichocolon: Clinique, radiologie, thérapeutique.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subgroup Analyses
Authors: Charles M. Grossman
Journal: Annals of Internal Medicine (1992)

Letters1 July 1992Subgroup AnalysesCharles M. Grossman, MDCharles M. Grossman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-1-93_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Oxman and colleagues (1) make some good arguments about the limitations of subgroup analysis and conclude that clinical practice should be based on "the average estimate of effect from the overall analysis (the more robust finding) or on a subgroup analysis (which more closely reflects the specific situation at hand)."The latter has too often been ignored, and generalizations have been broader than warranted by the data. The ISIS-1 report (2), for example, showed an impressive and statistically significant difference after the use of intravenous atenolol in acute myocardial infarction. Subgroup analyses showed large differences in mortality...References1. OxmanGuyatt AG. A consumer's guide to subgroup analyses. Ann Intern Med. 1992;116:78-84. LinkGoogle Scholar2. . Randomised trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction: ISIS-1. Lancet. 1986;2:57-66. MedlineGoogle Scholar3. . A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. JAMA. 1982;247:1707-14. CrossrefMedlineGoogle Scholar1. OxmanGuyatt AG. A consumer's guide to subgroup analyses. Ann Intern Med. 1992;116:78-84. LinkGoogle Scholar2. FurbergByington CR. What do subgroup analyses reveal about differential response to beta-blocker therapy? Circulation. 1983;67:98-101. Google Scholar3. YusufWittesProbstfielTyroler SJJH. Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials. JAMA. 1991;266:93-8. CrossrefMedlineGoogle Scholar4. . The Beta-Blocker Pooling Project (BBPP): subgroup findings from randomized trials in post infarction patients. Eur Heart J. 1988;9:8-16. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, OR 97205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe use of an internal teat sealant in combination with cloxacillin dry cow therapy for the prevention of clinical and subclinical mastitis in seasonal calving dairy cowsAntibiotics in preterm labour 1 July 1992Volume 117, Issue 1Page: 93-94KeywordsAcute myocardial infarctionMortalityResearch design Issue Published: 1 July 1992 PDF downloadLoading ...
New therapeutic strategies in radiation therapy
Authors: T. J. Kinsella
Journal: JAMA (1981)

Radiation therapy has been an integral part of curative cancer therapy for many decades. The tolerance of normal tissues traversed by radiation and resistant tumor cell populations traditionally have limited the radiocurability of certain tumors, especially with higher clinical stages. However, research in radiobiology and radiation physics is providing ways to increase cure while limiting morbidity. Computer-controlled dynamic treatment, radioprotector drugs, hyperbaric oxygen, carbogen breathing during irradiation, particle irradiation, and hypoxic cell sensitizing drugs are presently undergoing clinical evaluation with some encouraging preliminary results. We review the fundamental concepts underlying these clinical trials and analyze the results. (<i>JAMA</i>1981;245:1669-1674)
Global review of diet and cancer links available
Authors: C. Marwick
Journal: JAMA (1997)

A MAJOR REPORT on the relationship between nutrition and the development of cancer concludes that 3 million to 4 million cases of cancer per year could be prevented by appropriate diet and such lifestyle changes as reducing tobacco and alcohol consumption. The 670-page report,<i>Food, Nutrition and the Preven-</i><i>tion of Cancer: A Global Perspective</i>, is the result of 3 years of work by a panel of more than 150 scientists who reviewed and evaluated 4500 research studies. The document was prepared with the support of the American Institute for Cancer Research, Washington, DC, and the World Cancer Research Fund, London, England. Both seek to increase knowledge about the role of nutrition in the prevention of cancer. The report is probably the most comprehensive review and evaluation of scientific evidence on diet and cancer since the National Academy of Sciences' 1982 report,<i>Diet, Nutrition and Cancer</i>. "We considered the published
Body weight and longevity
Authors: John W. Beasley
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The article by Manson et al<sup>1</sup>entitled "Body Weight and Longevity" represents a worthwhile attempt to eliminate confounding variables in the examination of the relationship between body weight and longevity. Unfortunately, three additional variables that probably should have been looked at have not been. They are (1) physical activity, (2) social status, and (3) diet. Physical inactivity is positively correlated both with greater body weight and with mortality. Therefore, investigations of the relationship between body weight and longevity should include assessments of physical activity. Unfortunately, this is obviously extremely difficult to measure, but again, the failure to look at this variable weakens the establishment of a possible causal relationship between body weight and increased mortality. The second variable, that of social status, should also be examined since persons in the United States with a lower social status also have higher mortality. Lower social status is also
Treatment of myocardial ischaemia.
Authors: Briti Sh
Journal: BMJ (1967)

PointersIntensive Care: Description of organization and results in a respiratory unit set up after a Trea, preliminary survey to assess the need for such a unit in Glasgow (p. 255). AnginalVisuo-motor Handicap: Poor school performthe avai ance in spite of average I.Q. in a number of healthy children explained by visuo-motor defect. of coroi Some of these children had a history of peri- Until natal abnormality (p.259). blood flAspirin and Chronic Urticaria: Aspirin-connecrops taining drugs caused exacerbation in some must be patients with chronic urticaria.This action may be due to enhancement of effect of arteries histamine in the skin (p.262).ment in Salicylates in Rheumatoid Arthritis: Trial to arteries demonstrate clinical assessment of anti-inflam- the mor matory properties of rapidly acting drugs shows
Traumatic rupture of the thoracic aorta
Authors: J. W. Pate
Journal: JAMA (1968)

During a 15-month period, six patients with acute traumatic rupture of the arch of the aorta were treated. This experience demonstrated that delay in recognition and repair is disastrous and that the only long-term survivors had early surgical repair. The lesion is far more common, particularly associated with automobile accidents, than is usually recognized. Frequently, no evidence of chest injury is present, but deceleration stresses appear to be common to all cases. When both mediastinal widening on chest roentgenograms and a history of decelerating accident are present, aortography is indicated. When complete rupture of the aorta is demonstrated, emergency surgical repair should follow.
Expression of Multidrug-Resistance (MDR1) Gene in Normal Epithelia and in Invasive Carcinomas of the Uterine Cervix
Authors: G. F. Riou
Journal: JNCI Journal of the National Cancer Institute (1990)

Expression of Multidrug Resistance (MDR1) Gene in Normal Epithelia and in Invasive Carcinomas of the Uterine Cervix. JNCI 82:1493–1496 (1990). The financial support was inadvertently omitted. It should read “Supported in part by Institut Gustave Roussy (Contrat de Recherche Clinique 90D10) and Association pour la Recherche sur le Cancer (ARC, Villejuif, France).”
No demonstrable association between the Leningrad-Zagreb mumps vaccine strain and aseptic meningitis in a large clinical trial in Egypt
Authors: Hitt J. Sharma, Saeed Aly Oun, Shermine S. Abou Bakr, Subhash V. Kapre, Suresh S Jadhav, Subodh Bhardwaj
Journal: Clinical Microbiology and Infection (2009)
The Medical Record Visiting List or Physicians' Diary for 1935
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic and therapeutic technology assessment. Dorsal rhizotomy
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRAUMATIC NEUROSIS.
Authors: PHILIP ZENNER
Journal: JAMA (1907)

Traumatic neurosis is a nervous disease following injury, in which there is no demonstrable structural lesion of the nervous system. The symptoms are much like those of the common functional diseases of the nervous system, and may be spoken of as traumatic hysteria or traumatic neurasthenia. Commonly, however, we find symptoms of both of these disorders in the same patient and not rarely the clinical picture may not be that of either of them. Litigation is a frequent complication which materially affects the clinical history. It, not rarely, warps the judgment of the physician, and may doubly influence the patient, the many attendant conditions disastrously affecting his nervous system, while the money dangling over his head leads him, consciously or unconsciously, to distort his symptoms. The following cases are typical of a common form of traumatic neurosis, and a long period of observation gives special value to their study. I
Christmas Quiz (See Special Plate): Answers
Journal: BMJ (1970)

CHRISTMAS Qi 1 970 (Answers appear on Medical News 1.What condition may be caused by karate, marching, or beating conga drums? 2. What are the following?(a) Blue rubber bleb naevus disease.(b) Syndrome of the sea blue histiocyte.(c) Blue diaper syndrome. 3.With what diseases do you associate the following places? (a) Tangier Island.(b) Epping.(c) Minamata, Japan.(d) Iceland.(e) Gibraltar, Malta, and Cyprus.(f) Amsterdam.(g) Kuskokwim, Alaska.(h) Pingelap Atoll in _ the Pacific.
L-Asparaginase
Authors: R L Capizzi, J R Bertino, R E Handschumacher
Journal: Annual Review of Medicine (1970)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More