tbuckley/cabot-search huggingface dataset:
PERSONALITY OF MURDERESSES
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author index (vol. 16)
Authors: See Rosellini, M Amouretti, See Pelletier, See Trevisani, F Andrighetti, See Gonzalez, V Arienti, S Arii, See Adachi, See Spina, See Zironi, J Barrera, Eugenia Hernandez, G Marchesini, C Camporesi
Journal: Journal of Hepatology (1992)
DOMESTIC CORRESPONDENCE.
Authors: H. K. Cushing
Journal: JAMA (1884)

Dr. N. S. Davis: <h3>Dear Sir:</h3> —The second section of the Report of the Judicial Council of the American Medical Association, at its late meeting, announced that some tacts had come to its knowledge rendering it probable that the Cuyahoga County Medical Society had been derelict, in not requiring its members to observe the Code of Ethics. At the next meeting of the Society after the report was made public in the AssociationJournal, the committee now addressing you was chosen to present to the Council, through the pages of theJournal, an epitome of the Society's course in connection with the instances of the violation of the Code which have of late been acted upon by it, and which it is supposed have supplied the facts referred to in the Council's report. The Society numbers some eighty members, and it is not surprising that it should at times have
Drugs and emotional support are effective against depression in primary care
Journal: BMJ (1999)

Haemophilus influenzae type b vaccine is not linked to diabetes Environmental risk factors for type 1 diabetes remain unknown.It has been speculated that some vaccines might trigger it, although data are lacking.On p 1169 Karvonen et al describe their findings from a nationwide randomised study on the association between Haemophilus influenzae type b vaccination and type 1 diabetes in Finland, which has the highest incidence of type 1 diabetes.The risk of type 1 diabetes during the first 10 years of life was similar in children vaccinated with H influenzae type b at 3 months and those immunised at 24 months only.Moreover, the incidence of the disease in the immunised children was no different from that in those children born during the two years before the start of the vaccination programme.It is unlikely that H influenzae vaccination causes type 1 diabetes in children.
The immunization of children enrolled in the Special Supplemental Food Program for Women, Infants, and Children (WIC). The impact of different strategies
Authors: G. S. Birkhead
Journal: JAMA (1995)

<h3>Objective.</h3> —To assess the impact of different interventions to increase measles vaccination coverage among preschool children enrolled in the Special Supplemental Food Program for Women, Infants, and Children (WIC). <h3>Design.</h3> —Public health intervention trial. <h3>Setting.</h3> —Six volunteer WIC sites in New York City. <h3>Study Participants.</h3> —Children aged 12 to 59 months presenting for WIC certification between April 1 and September 30, 1991, who were eligible for measles vaccination. <h3>Interventions.</h3> —Two WIC sites were assigned at random to one of three immunization strategies: (1) escort: child was escorted to a nearby pediatric clinic for immunization; (2) voucher incentive: the family returned monthly, rather than every 2 months, to pick up WIC food vouchers until the child was immunized; or (3) referral: the family was passively referred for immunization. <h3>Main Outcome Measure.</h3> —Proportion of eligible children receiving measles vaccination. <h3>Results.</h3> —Of children eligible for measles immunization, 74% (618/836) were immunized. Children at escort sites were 5.5 times (relative risk [RR]=5.5; 95% confidence interval [CI], 3.7 to 8.1) and those at voucher incentive sites were 2.9 times (RR=2.9; 95% CI, 1.9 to 4.5) more likely to be immunized than children at referral sites. Children were immunized more rapidly at escort sites (median, 14 days) and voucher incentive sites (median, 26 days) than at referral sites (median, 45 days;<i>P</i>&lt;.001). <h3>Conclusions.</h3> —Both escort and voucher incentive models resulted in more children being immunized more rapidly than passive referral. Because of ease of administration, voucher incentives may be a more suitable immunization intervention for use at WIC sites, with addition of escort where feasible. (<i>JAMA</i>. 1995;274:312-316)
Stenosis following tracheostomy for respiratory care
Authors: B. Geffin
Journal: JAMA (1971)

Thirty-two patients with symptomatic tracheal deformity following ventilatory assistance through cuffed tracheal tubes have been treated during a seven-year period. The diagnosis is strongly suggested by symptoms of upper-airway obstruction following decannulation. Radiologic studies and bronchoscopy are invaluable diagnostic adjuncts. The lesions may consist of deformity of anterior wall or stenosis at the tracheostomy site, or more typically, of circumferential stenotic lesions at the level of the inflatable cuff. Tracheomalacia also occurs. The etiology appears primarily to be pressure necrosis caused by the rigidly inflated cuff, with subsequent cicatrization. Resection of the stenosis and primary reconstruction of the trachea is the definitive treatment of choice, as results are generally good. Dilatation and stenting are usually of temporary values only. In a small number of patients, permanent tracheostomy must be accepted.
Comparative Effectiveness of Generic and Brand-Name Statins on Patient Outcomes
Journal: Annals of Internal Medicine (2014)

Background: Statins are effective in preventing cardiovascular events, but patients do not fully adhere to them.Objective: To determine whether patients are more adherent to generic statins versus brand-name statins (lovastatin, pravastatin, or simvastatin) and whether greater adherence improves health outcomes.Design: Observational, propensity score-matched, new-user cohort study.Setting: Linked electronic data from medical and pharmacy claims.Participants: Medicare beneficiaries aged 65 years or older with prescription drug coverage between 2006 and 2008.Intervention: Initiation of a generic or brand-name statin.Measurements: Adherence to statin therapy (measured as the proportion of days covered [PDC] up to 1 year) and a composite outcome comprising hospitalization for an acute coronary syndrome or stroke and all-cause mortality.Hazard ratios (HRs) and absolute rate differences were estimated.Results: A total of 90 111 patients who initiated a statin during the study was identified; 83 731 (93%) initiated a generic drug, and 6380 (7%) initiated a brand-name drug.The mean age of patients was 75.6 years, and most (61%) were female.The average PDC was 77% for patients in the generic group and 71% for those in the brand-name group (P Ͻ 0.001).An 8% reduction in the rate of the clinical outcome was observed among patients in the generic group versus those in the brand-name group (HR, 0.92 [95% CI, 0.86 to 0.99]).The absolute difference was Ϫ1.53 events per 100 person-years (CI, Ϫ2.69 to Ϫ0.19 events per 100 person-years).Limitation: Results may not be generalizable to other populations with different incomes or drug benefit structures. Conclusion:Compared with those initiating brand-name statins, patients initiating generic statins were more likely to adhere and had a lower rate of a composite clinical outcome.
Holistic Medicine
Authors: Michael Glasser
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The remarks made by John P. Callan, MD (241:1156, 1979), in his editorial "Holistic Health or Holistic Hoax?" are certain to provoke a landslide of reactions. Much of this reaction will likely be from representatives of specific holistic associations taking exception with statements regarding their organizations. While this information is valuable, I think there are three general points that beg discussion in light of Dr Callan's comments, namely, the cost of health care, the participation of the patient in health care, and the changing nature of the patientprovider relationship. First, the issue of cost is relatively straightforward. It is no secret that the cost of medical care is high. That "legitimate physicians," to quote Dr Callan, are willing to advocate a position, or more appropriately positions, that emphasize preventive care should be welcomed rather than suspected. Further, from the consumer point of view, is it really any
Silicone implants and esophageal dysmotility. Are breast-fed infants at risk?
Authors: J. A. Flick
Journal: JAMA (1994)

The association between silicone breast implants and the development of rheumatic disease in their recipients has been suggested by a growing number of case reports.<sup>1,2</sup>Although prospective studies of implant recipients are awaited to confirm and quantify the risk of autoimmune disease associated with silicone breast prostheses, available evidence was considered sufficient to prompt the Food and Drug Administration's January 1992 request for a voluntary moratorium on further implantation of these devices and subsequent policy restricting implant availability to controlled, clinical trials. A variety of rheumatologic diseases have been reported among implant recipients, with a high proportion of patients displaying a sclerodermalike illness. Pathogenetic mechanisms are unknown. Bleeding of silicone out of implants into periprosthetic tissues, as well as migration to more distant sites including regional lymphoid tissue, is known to occur. The potential for initiating a systemic immune response therefore exists, although most women with silicone breast implants
THE RECORD KEEPING OF EXEMPT NARCOTIC PREPARATIONS
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Involvement of RNA in Protein Synthesis
Authors: Jonathan R. Warner, Ruy Soeiro
Journal: New England Journal of Medicine (1967)

IN 1940 the work of Beadle and Tatum1 established the concept that the genes carry out their function by controlling specific proteins. At approximately the same time Brachet2 and Caspersson3 independently concluded that ribonucleic acid (RNA) was somehow associated with protein synthesis. In the next fifteen years, several major advances were made: DNA was identified as the genetic material4; its double helical structure was elucidated5; it was postulated that DNA carries information as a sequence of nucleotide bases, from which a complementary copy can be made6; and the ribosomes, containing most of the cell's RNA, were identified . . .
Pasteurella Multocida Infections. A Report of Six Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Apotransferrin on Iron Release From Caco-2 Cells, an Intestinal Epithelial Cell Line
Authors: Xavier Alvarez-Hernandez, Margaret Smith, Jonathan Glass
Journal: Blood (1998)

The Caco-2 cell line grown in bicameral chambers was used to study the effect of transferrin in the basal chamber on the transepithelial transport of iron. We have shown that when iron was offered as59Fe on the apical surface of the Caco-2 cells, transport of 59Fe into the basal chamber was stimulated by 50 μmol/L apotransferrin. Here, we examined the effect on59Fe transport of lower concentrations of apotransferrin, as well as the effects on transport of ovo-, cobalt-, and ferri-transferrin and of iron chelators with an affinity for iron greater than that of transferrin. The stimulation of 59Fe transport was more sensitive to the presence of apotransferrin with a Km of 0.078 ± 0.008 μmol/L compared with ferri-transferrin with a Km of 1.24 ± 0.39 μmol/L (P &lt; .006). 59Fe transport was less sensitive to diethylenetriaminopenta-acetic acid (DTPA) than apotransferrin with Kms of 1.52 ± 0.70. The chelator nitrilotriacetic acid (NTA) exhibited no stimulation of59Fe transport. Analysis of laser scanning confocal micrographs showed that apotransferrin labeled with Texas Red is internalized by Caco-2 cells from the basal side and localizes in distinct vesicles above the nucleus. The sensitivity of apotransferrin in stimulating Fe transport suggests a unique interaction of apotransferrin with the basal surface of the intestinal epithelium.
Pulmonary Metabolism of Foreign Compounds: Its Role in Metabolic Activation
Authors: Gerald M. Cohen
Journal: Environmental Health Perspectives (1990)

The lung has the potential of metabolizing many foreign chemicals to a vast array ofmetabolites with different pharmacological and toxicological properties.Because many chemicals require metabolic activation in order to exert their toxicity, the cellular distribution of the drug-metabolizing enzymes in a heterogeneous tissue, such as the lung, and the balance of metabolic activation and deactivation pathways in any particular cell are key factors in determining the cellular specificity ofmany pulmonary toxins.Enviroxnmental factors such as air pollution, cigarette smoking, and diet markedly affect the pulmonary metabolism of some chemicals and, thereby, possibly affect their toxicity.
The state of federal health statistics on racial and ethnic groups
Authors: R. A. Hahn
Journal: JAMA (1992)

<h3>Objective.</h3> —To examine assumptions underlying federal health statistics on racial and ethnic groups in the United States. <h3>Data Sources.</h3> —Studies conducted by federal agencies and other investigators, and technical appendices of published vital statistics and census reports. <h3>Data Synthesis.</h3> —Several assumptions underlying federal health statistics on racial and ethnic groups are not well supported. Conceptual (as opposed to operational) definitions of race and ethnicity are not available, and scientific grounds for definition are not considered. Procedures for the ascertainment of race and ethnicity vary within and among data-collection agencies. Miscounting and misclassification may vary by an order of magnitude between whites and other races. The responses of individuals to questions of racial and ethnic identity differ for different indicators, in different surveys, and at different times. As a result, counts, rates, and rate ratios may not be meaningful or accurate. Particularly for Hispanics and for races other than whites or blacks, there are inconsistencies in statistical information that may hinder health research and program development. <h3>Conclusions.</h3> —Improvement of federal health statistics for racial and ethnic groups requires (1) clarification of goals for classification, (2) adoption of scientific principles for the validation and definition of the categories "race" and "ethnicity," (3) assessment of perceived social identity in the population, and (4) periodic evaluation. (<i>JAMA</i>. 1992;267:268-271)
Detection of a unique gamma-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: A new candidate for early diagnosis of hepatocellular carcinoma
Authors: M Tsutsumi
Journal: Hepatology (1996)

Many studies concerning gamma-glutamyl transpeptidase (GGTP) in hepatocellular carcinoma (HCC) have suggested that changes in hepatic GGTP expression may be closely related to the development of HCC. However, its mechanisms are not well known, and genomic analysis of the specific GGTP to HCC is also lacking. Recently, the human GGTP complementary DNA (cDNA) sequences from fetal liver, placenta, and HepG2 cells have been published. In the present study, we sought to clarify the distribution of the GGTP messenger RNA (mRNA) molecular species in human liver and determine whether alterations in GGTP mRNA expression occur upon the development of HCC. The specific primer sets for reverse-transcription polymerase chain reaction (PCR) corresponding to the 5'-noncoding human GGTP mRNA of fetal liver (type A), HepG2 cells (type B), and placenta (type C) were prepared. Oligonucleotide probes specific for each type of mRNA were also synthesized. Liver tissues were obtained from patients with or without HCC, and total RNA was extracted. Total RNA was also extracted from various organs obtained from one male patient upon autopsy. Types of GGTP mRNAs were analyzed using type-specific primer sets and oligonucleotide probes. The types of GGTP mRNA varied in different organs. In normal liver and diseased liver without HCC, the main type of GGTP mRNA was type A. The expression was monogenic in most cases but was polygenic in some cases. In the polygenic cases, type C was common, but type B was found occasionally. On the other hand, type B was predominant in cancerous tissues with HCC. In noncancerous tissues of livers with HCC, the main types were types A and B. The prevalence of type B was significantly higher in both cancerous and noncancerous tissues of livers with HCC than in livers without HCC. The prevalence of type A in cancerous tissue, but not in noncancerous tissue, was significantly lower than in livers without HCC. These results strongly suggested that the GGTP mRNA expression in human liver may shift from type A to type B during the development of HCC. The high prevalence of type B in noncancerous tissues suggested that the shift of the GGTP mRNA may occur from the preneoplastic stage of hepatocytes. (Hepatology 1996 May;23(5):1093-7)
Medical Journal of Australia, Sydney
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: The impact of a routine late third trimester growth scan on the incidence, diagnosis, and management of breech presentation in Oxfordshire, UK: A cohort study
Authors: Ibtisam Salim, Eleonora Staines-Urias, Sam Mathewlynn, Lior Drukker, Manu Vatish, Lawrence Impey
Journal: PLoS Medicine (2021)

There is an error in the Author summary section in the first bullet point under the heading "What did the researchers do and find?"The correct sentence should read: "This study assessed breech outcomes of 27,825 term births before and after the introduction of a third trimester screening ultrasound, which increased the proportion of pregnancies screened from 39% to 99%".
Bazex's syndrome. Paraneoplastic acrokeratosis
Authors: J. A. Witkowski
Journal: JAMA (1982)

Paraneoplastic acrokeratosis is a specific sign of cancer of the upper airway and upper digestive tract. The distinctive cutaneous changes include erythematous to plum-colored scaly acral lesions, paronychia, nail dysplasia, and keratoderma. (<i>JAMA</i>1982;248:2883-2884)
Some misuses of health statistics
Authors: E. G. Ludwig
Journal: JAMA (1971)

Statistics show that the risk of dying from an illness while in the hospital is many times greater than the risk of dying from an illness while at home. By the same token, there is a strong association between dying and being in bed. While most of us may not be able to precisely identify and explain the logical fallacies implied by this type of statistical reasoning, the nonsense of it is sufficiently apparent so that no one is likely to avoid beds or hospitals in order to prolong his life. Yet the same sort of statistics too often finds its way into the general health literature and mass media where the errors of logic are less apparent and pass unrecognized. No one would deny the important contributions that the proper use of statistics has made to the advancement of medicine and public health. Epidemics are brought under control, drugs