tbuckley/cabot-search huggingface dataset:
SUN-BATHS AND COMMON SENSE
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stem-Cell Research — Signposts and Roadblocks
Journal: New England Journal of Medicine (2005)

On page 2527, in the left-hand column, lines 15 through 17 of the third full paragraph should have read ". . .they have a similar benefit after primary angioplasty for acute ST-elevation myocardial infarction," rather than "for acute non-ST-elevation myocardial infarction," as printed.
Effects of hypoxia on granulocytic‐monocytic progenitors in rats. Role of bone marrow stroma
Authors: Rashmi Taneja, Pranela Rameshwar, Jeffrey Upperman, Ming T. Wang, David H. Livingston
Journal: American Journal of Hematology (2000)

Hemorrhagic shock leads to hypoxia and is associated with bone marrow (BM) failure. Hemorrhagic shock is also a predisposing factor in immune dysregulation. Since the BM is the major organ of immune cells in the adult, its failure following hemorrhagic shock may explain the increased susceptibility to infection. The in vitro evidence indicates that hypoxia mediates altered functions in BM stroma. Since similar hematopoietic alterations are reported in hypoxia and hemorrhagic shock, hypoxia alone could be a representative model to study BM responses during hemorrhagic shock. In this study, we use an animal model to dissect the hematopoietic effects of hypoxia. We subjected rats to hypoxia, and at days 1 and 5 post-hypoxia we determined the numbers of granulocytic–monocytic progenitors (CFU-GM) in the BM. We found significant increase (P < 0.05) in CFU-GM at day 1 and a downward trend by day 5. Enhanced BM cellularity could not explain the increase in CFU-GM by day 1. BM stromal cells mediated most of the stimulatory effects by hypoxia. CFU-GM was inversely proportional to bioactive TGF-β and directly proportional to IL-1. Compared to normoxic rats, IL-6 production was suppressed in BM cells from hypoxic rats. The results show that hypoxia alone initiate a stimulatory response in CFU-GM progenitors. These effects are at least partially mediated through the BM stroma. In the absence of a second insult, CFU-GM reverts to baseline. The data also suggest that hypoxia mediates complex responses that include cytokine production. These results add to the current understanding of hematopoietic responses by hypoxia and adds to the mechanisms of immune dysfunctions following hemorrhagic shock. Am. J. Hematol. 64:20–25, 2000. © 2000 Wiley-Liss, Inc.
Absolution
Authors: George Girey
Journal: Annals of Internal Medicine (1991)

Ad Libitum1 September 1991AbsolutionGeorge Girey, MDGeorge Girey, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-5-405 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWisps of grayfanned across her pillowa corona around a rosereplaced by a skeleton's mask,her form made softby a snow-white patinathat touched her hillsand graciously unbrokenglided across her ravaged valleys.At her center in dark hollowsa pair of sapphires,and I immobilized.In wispy voice she spoke:You bend so wearily my friend.Come, sit by me.Recall our first meetinghow we browsedyour armoryplanning our strategydesigning our tactics.Give me your hand.Forget thoughts of regret,we are allies on the rock of reality.I hated youfor... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: George Girey, MDAffiliations: Woodland Hills, CA 91367 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1991Volume 115, Issue 5 Page: 405-405 Keywords Emotions Skeleton ePublished: 1 December 2008 Issue Published: 1 September 1991 PDF downloadLoading ...
Finding Recent Tuberculous Infection in New Orleans
Authors: Harry B. Greenberg
Journal: JAMA (1976)

We tested infants and preschool-age children from the New Orleans Health Department programs for tuberculosis contact investigation and for tuberculin skin testing. About 7.8% (34 of 438) of the contacts and about 0.78% (107 of 13,797) of those given skin tests were tuberculosis-infected. Both programs, we concluded, detected enough recent tuberculous infection to be worthwhile as screening procedures. (<i>JAMA</i>235:931-932, 1976)
Grant Support Omitted.
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Authors: Ruiben Feng, Claire Rampon, Ya-Ping Tang, David Shrom, Janice Jin, Maureen Kyin, Bryce Sopher, Miles W. Miller, Carol B. Ware, George M. Martin, Seong H. Kim, Ronald B. Langdon, Sangram S. Sisodia, Joe Z. Tsien
Journal: Neuron (2002)
National Diabetes Month — November 2015
Authors: Karen Kirtland, Pyone Cho, Linda Geiss, Thomas Frieden, Harold Jaffe, Joanne Cono, Chesley Richards, Michael Iademarco, Sonja Rasmussen, Charlotte Kent, Jacqueline Gindler, Teresa Rutledge, Douglas Weatherwax, Soumya Dunworth, Teresa Hood, Martha Boyd, Maureen Leahy, Julia Martinroe, Stephen Spriggs, Moua Yang, Quang Doan, Phyllis King, Teresa Moreland, Terraye Starr, Timothy Jones, Matthew Boulton, Virginia Caine, Katherine Daniel, Jonathan Fielding, David Fleming, William Halperin, King Holmes, Robin Ikeda, Rima Khabbaz, Phyllis Meadows, Jewel Mullen, Jeff Niederdeppe, Patricia Quinlisk, Patrick Remington, Carlos Roig, William Roper, William Schaffner, Paul Creswell
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

November is National Diabetes Month.In the United States, approximately 29 million persons have diabetes, and an additional 86 million adults have prediabetes, putting them at risk for developing type 2 diabetes, heart disease, and stroke (1).Persons with diabetes can take steps to control the disease and prevent complications, and those with prediabetes can prevent or delay the onset of type 2 diabetes through weight loss, healthy eating, and physical activity (1,2).After decades of continued increases, the prevalence of diabetes changed little from 2007-2008 to 2011-2012 (3).CDC and the American Medical Association has launched Prevent Diabetes STAT: Screen, Test, Act Today (http://www.preventdiabetesstat.org).This multiyear initiative includes a toolkit (http://www.cdc.gov/diabetes/prevention/pdf/STAT_toolkit.pdf ) to help persons determine their risk for type 2 diabetes and to guide health care providers on the best methods to screen patients for prediabetes and refer patients at high risk to prevention programs.The CDC-led National Diabetes Prevention Program promotes diabetes prevention programs that focus on lifestyle changes in communities throughout the United States (4).More information about CDCrecognized diabetes prevention programs is available at https://nccd.cdc.gov/DDT_DPRP/Registry.aspx.
Effects of Carotid Compression, as Assessed by near Infrared Spectroscopy, upon Cerebral Blood Volume and Haemoglobin Oxygen Saturation
Authors: M Ferrari, E Zanette, G Sideri, I Giannini, C Fieschi, A Carpi
Journal: Journal of the Royal Society of Medicine (1987)

Near infrared spectroscopy, a recently developed optoelectronic technique, has been studied as a possible method of monitoring the adequacy of cerebral perfusion in 22 patients who were candidates for carotid endarterectomy. Using this technique, changes in haemoglobin volume, haemoglobin oxygen saturation and redox level of cytochrome-c-oxidase were recorded from the frontoparietal region during routine carotid compression tests performed under continuous electroencephalographic (EEG) monitoring. A highly significant association was found between EEG slowing, indicating impaired cerebral function, and a fall in haemoglobin volume and oxygen saturation, indicating a reduced blood and oxygen supply to the brain (Fisher exact test, P less than 10(-5]. In a few tests haemoglobin volume and oxygen saturation were reduced without changes in the EEG recording. This study raises new issues concerning the compensatory mechanisms taking place during carotid occlusion and suggests that near infrared spectroscopy might be useful in monitoring the blood and oxygen supply to the brain during carotid endarterectomy.
Atheromatous microembolism simulating polymyositis
Authors: T. A. Haygood
Journal: JAMA (1968)

A case of atheromatous microembolism to the lower extremities illustrated some typical findings: sudden onset of leg pain, cool legs with normal peripheral pulses, petechiae, livedo reticularis, and elevated, tender nodules which represented muscle necrosis. The dominant clinical picture was consistent with acute polymyositis. Diagnosis of atheromatous microembolism with muscle necrosis was confirmed by muscle biopsy.
Carcinoembryonic Antigen in Management of Colorectal Carcinoma
Journal: BMJ (1974)

Association for Medical Education in EuropeThe offices of the newly-formed Association for Medical Education in Europe (AM.E.E.) have been set up in Dundee.The association has been founded to integrate the work of the numerous national bodies concerned with medical education so that the prob- lems, innovations, and progress in the different countries can be made known across Europe.
Treatment of obesity in adults. Council on Scientific Affairs
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Norovirus Outbreak
Authors: Bridget Kuehn
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Olaparib as maintenance treatment following first-line platinum-based chemotherapy (PBC) in patients (pts) with a germline BRCA mutation and metastatic pancreatic cancer (mPC): Phase III POLO trial
Authors: D.-Y. Oh, T. Golan, P. Hammel, M. Reni, E. Van Cutsem, T. Macarulla, M.J. Hall, J.O.H. Park, D. Hochhauser, D. Arnold, A. Reinacher-Schick, G. Tortora, H. Algül, E.M. O'Reilly, D. McGuinness, K.Y. Cui, K. Schlienger, G.Y. Locker, H.L. Kindler
Journal: Annals of Oncology (2019)
A phase 2 clinical trial of pemetrexed plus gemcitabine as front-line chemotherapy for patients with malignant pleural mesothelioma (MPM)
Authors: P. A. Janne, C. Obasaju, G. Simon, R. Taub, K. Kelly, P. Fidias, L. P. Bloss, H. L. Kindler
Journal: Journal of Clinical Oncology (2004)

7053
Malignant Hyperthermia
Authors: Ray McKenzie, Antonio J. Amortequi
Journal: JAMA (1971)

<h3>To the Editor.—</h3> It would be a shame if the interesting case study entitled "Malignant Hyperpyrexia During Anesthesia" by Arens and McKinnon (<b>215</b>:919, 1971) was allowed to appear without comment. It is true that this entity is well recognized, but the etiology apart from genetic causes in a family series is obscure. A postoperative fever of 104 F even with trismus of the jaw and marked fasciculations following succinylcholine does not establish the diagnosis. In spite of the authors being aware of Modell's 1966 report,<sup>1</sup>there is no mention of blood cultures or cultures of the solutions administered to the patients. Should such a case occur again it must be mandatory to obtain blood cultures from the patient and cultures of all agents given intravenously as well as from the tubing and ports of the intravenous set. Postoperative iatrogenic infection is a much more common entity than malignant hyperpyrexia.
Germinal Centers
Authors: Ian C. M. MacLennan
Journal: Annual Review of Immunology (1994)

Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help. After immunization with a single dose of protein-based antigen, the germinal centers formed are oligoclonal; on average three B blasts colonize each follicle. These blasts undergo massive clonal expansion and activate a site-directed hypermutation mechanism that acts on their immunoglobulin-variable (Ig-v)-region genes. Mature germinal centers are divided into dark and light zones. The proliferating blasts, centroblasts, occupy the dark zone and give rise to centrocytes that are not in cell cycle and fill the light zone. The light zone contains a rich network of follicular dendritic cells (FDC) that have the capacity to take up antigen and hold this on their surface for periods of more than a year. The antigen is held as an immune complex in a native unprocessed form; but the antigen may be taken up from FDC by B cells, which can process this and present it to T cells. Centrocytes appear to be selected by their ability to interact with antigen held on FDC. There is a high death rate among centrocytes in vivo, and when these cells are isolated in vitro, they undergo apoptosis within hours on culture. The onset of apoptosis can be delayed by cross-linking centrocytes' surface Ig, and long-term survival is achieved by signalling through their surface CD40. After activation through CD40 the centrocytes increase their surface Ig and acquire characteristics of memory and processing of antigen held on FDC and its presentation to T cells that can be induced to express CD40 ligand at the point of cognate interaction. Other signals that induce a proportion of germinal center cells to become plasma cells have also been described. Germinal centers persist for about 3 weeks following immunization, but after this, memory B blasts continue to proliferate in follicles throughout the months of T cell-dependent antibody responses. These cells are probably the source of plasma cells and memory cells required to maintain long-term antibody production and memory after the first 3 weeks of T cell-dependent antibody responses.
Decrease in serum levels of markers of hepatic connective tissue turnover during and after treatment of chronic hepatitis B with interferon-α
Authors: J Teran
Journal: Hepatology (1994)

Interferon-α induces remission in 30% to 40% of patients with chronic hepatitis B, but its effect on hepatic connective tissue turnover has not been well documented. We studied the changes in serum procollagen III propeptide and laminin-P1 peptide (Lam-P1) in 33 patients with chronic hepatitis B (11 nontreated controls and 22 treated patients) during a 4-mo randomized trial of interferon-α. Liver biopsy specimens were obtained at the start of treatment and 12 mo later. Liver biochemical tests, procollagen III propeptide, laminin-P1 peptide and hepatitis B virus DNA polymerase were determined before treatment with interferon was begun (mo -3), at the initiation (0 time) and completion of treatment (mo 4) and also at 8, 12 and 18 mo. Treated patients were classified as “responders” and “nonresponders” on the basis of clearance of HBV e antigen from serum. There were no significant changes in the control group, whereas the responders had persistent decreases in ALT, AST, hepatitis B virus dna polymerase, procollagen III propeptide and laminin-P1 peptide. The nonresponders had transient ALT, AST and hepatitis B virus dna polymerase reductions that returned toward baseline levels during follow-up, but procollagen III propeptide and laminin-P1 peptide persisted below the baseline at mo 18. Significant correlations between procollagen III propeptide and laminin-P1 peptide with ALT, AST and liver histologic specimens were noted at baseline but not after 12 mo. Changes in procollagen III propeptide levels also correlated with changes in AST, ALT and liver histologic specimens. On the basis of logistic regression, neither markers of connective tissue turnover nor histology improved the accuracy of AST, ALT and hepatitis B virus dna polymerase for predicting response to interferon. We conclude that interferon treatment induces a persistent suppression in serum markers of hepatic connective tissue turnover in chronic hepatitis B patients independent of its effect on viral replication and hepatic necroinflammation. (HEPATOLOGY 1994;19:849–856.)
Drug Nephrotoxicity
Authors: R J Walker, G G Duggin
Journal: The Annual Review of Pharmacology and Toxicology (1988)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Shelter for the Twenty-First Century
Authors: John D. Spengler
Journal: Environmental Health Perspectives (1990)

Housing for the twenty-first century will be shaped by the changes that are occurring in society. These include the demographics of the occupant, the products and materials used for construction and furnishing, and the basic use of the structure. An aging population will have different demands on design and function. The health concerns of an aging population encompass chronic degenerative diseases as well as injury. The lessons of the past must make us mindful that chronic, low-level exposures to substances can occur at home. Products and materials used in homes can release vapors that may affect immunologic and neurologic function. Manifestations of dysfunctions will be more important as our population ages and if there is a continued reliance on new chemical formulation for products used in homes and workplaces. The future portends changes in functional use of residences. Electronic communications and robotics will decentralize our work force. Manufacturing or office functions will occur at home. This will present new challenges for health and safety for both monitoring and prevention.
Perioperative anesthetic risk of noncardiac surgery in hypertrophic obstructive cardiomyopathy
Authors: R. C. Thompson
Journal: JAMA (1985)

To determine their perioperative risk, we reviewed the records of 35 patients with hypertrophic cardiomyopathy diagnosed by cardiac ultrasound and/or catheterization who underwent general (52) or spinal (four) anesthesia—a total of 56 major surgical procedures. There were no operative or related perioperative deaths and no significant ventricular tachyarrhythmias. Intraoperative or postoperative complications included: myocardial infarction with heart failure in one patient who also had coronary artery disease and was one of three patients who had spinal anesthesia, arrhythmia requiring therapy in eight, and angina during supraventricular tachycardia in one. We conclude that the risk of general anesthesia and major noncardiac surgery is low in patients with hypertrophic obstructive cardiomyopathy. Spinal anesthesia, which decreases systemic vascular resistance and increases capacitance, may be relatively contraindicated. Concomitant coronary artery disease may increase the risk. (<i>JAMA</i>1985;254:2419-2421)