tbuckley/cabot-search huggingface dataset:
SMALLPOX.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serotonin and the dumping syndrome
Authors: F. A. Reichle
Journal: JAMA (1967)

Recent evidence indicates that a humoral factor may be involved in the etiology of the dumping syndrome. The similarities between the symptoms of the dumping complex and those of hyperserotonemia have led to investigations designed to determine whether increased release or formation of serotonin may be involved in the pathophysiology of the dumping syndrome. Increased portal-vein serotonin levels have been demonstrated after hypertonic stimulation of proximal small bowel in dogs.<sup>1</sup>Although altered serotonin levels in human dumping syndrome have been reported,<sup>2</sup>the serotonin changes have not been found consistently.<sup>3</sup>In the work reported here, repeated determinations in specially prepared platelet-rich plasma from peripheral venous blood showed consistent increases in serotonin levels after oral administration of glucose to patients with the dumping syndrome and after intraduodenal instillation of glucose to patients with normal gastrointestinal tracts. The levels in control patients given hypertonic glucose orally were unchanged. Thus the
Update: Alcohol-Related Traffic Crashes and Fatalities Among Youth—United States, 1982-1994
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantitative Cancer Risk Assessment for Dioxins Using an Occupational Cohort
Authors: Heiko Becher, Karen Steindorf, Dieter Flesch-Janys
Journal: Environmental Health Perspectives (1998)

We consider a cohort of 1 189 male German factory workers (production period 1952-1984) who produced phenoxy herbicides and were exposed to dioxins.Follow-up until the end of 1992 yielded a significantly increased standardized mortality ratio (SMR) for total cancer (SMR 141; 95% confidence interval 117-168).2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) concentrations up to 2252 ng/kg body fat were measured in 275 cohort members.Other higher chlorinated dioxins and furans also occurred in high concentrations.For quantitative analysis, the integrated TCDD concentration over time was used as an exposure variable, which was calculated using results from half-life estimation for TCDD and workplace history data.The other congeners were expressed as toxic equivalency (TEQ) and compared to TCDD using international toxic equivalency factors.Poisson and Cox regressions were used to investigate dose-response relationships.Various covariables (e.g., exposure to f-hexachlorocyclohexane, employment characteristics) were considered.In all analyses, TCDD and TEQ exposures were related to total cancer mortality.The power model yielded a relative risk (RR) function RR(xI= (1 +0.17x)0326 for TCDD (in microgram/kilogram blood fatxyears)-only a slightly better fit than a linear RR function-and RR() = (1 + 0.023X0.795for TEQ.Investigations on latency did not show strong effects.Different methods were applied to investigate the robustness of the results and yielded almost identical results.The results were used for unit risk estimation.Taking into account different sources of variation, an interval of 1 03 to 10-2 for the additional lifetime cancer risk under a daily intake of 1 pg TCDD/kg body weight/day was estimated from the dose-response models considered.Uncertainties regarding the dose-response function remain.These data did not indicate the existence of a threshold value; however, such a value cannot be excluded with any certainty.
Lippincott's Pocket Formulary.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meetingplace
Authors: Martha Leslie
Journal: Annals of Internal Medicine (1997)

Ad Libitum15 January 1997MeetingplaceMartha Leslie, MDMartha Leslie, MDThe Stanford University Clinic, Palo Alto, CA 94304Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-2-199701150-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Sun rose in the eastdawn of promisestwilight of tearsquiet passes yearsbrief the joy and mourning of our agecourage, man, couragestand with methis is our momentin eternityto be rememberedrememberingnothinglasts foreversave affection we share togethertime, capricious vixen, hastensthis day forward onthe sweeter for its scarcitylike a garden in the dawn Author, Article, and Disclosure InformationAffiliations: The Stanford University Clinic, Palo Alto, CA 94304Corresponding Author: Martha Leslie, MD, The Stanford University Clinic, 900 Blake Wilbur Drive, Suite W2080, Palo Alto, CA 94304-2205. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1997Volume 126, Issue 2Page: 136 ePublished: 15 August 2000 Issue Published: 15 January 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Dengue fever
Authors: Senanayake A M Kularatne
Journal: BMJ (2015)

This clinical review has been developed for <i>The BMJ</i> in collaboration with BMJ Best Practice, based on a regularly updated web/mobile topic that supports evidence based decision making at the point of care. To view the complete and current version, please refer to the dengue fever (http://bestpractice.bmj.com/best-practice/monograph/1197.html) topic on the BMJ Best Practice website.
Reply
Authors: S.I. White, P.S. Friedman, Ann Stratton
Journal: British Journal of Dermatology (1987)

Journal Article Reply Get access S.I. White, S.I. White Department of Dermatology, University of Glasgow, Glasgow, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.S. Friedman, P.S. Friedman Department of Dermatology, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K. Search for other works by this author on: Oxford Academic Google Scholar Ann Stratton Ann Stratton Regional Transfusion Centre, Newcastle upon Tyne, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 116, Issue 4, 1 April 1987, Page 608, https://doi.org/10.1111/j.1365-2133.1987.tb05891.x Published: 01 April 1987
Immunobiology of Transplantation. The Histocompatibility Systems.
Journal: Annals of Internal Medicine (1974)

Technical methodThe use of this graph paper requires no data processing and is therefore somewhat simpler than the ratio method described by Hales and Randle (1963), as well as more convenient and more accurate than the conventional curve-fitting procedure.Calculation of the total quantities of digoxin bound by the antibody reveals that binding was approximately constant through the range of concentrations tested, as expected from the linearity of the graph shown in the figure.With increasing concentration, however, binding declined slightly, which suggests that it may be inhibited at particularly high concentrations of ligand.The reason for this is unknown at present.
Transfer of technology from statistical journals to the biomedical literature. Past trends and future predictions
Authors: D. G. Altman
Journal: JAMA (1994)

<h3>Objective.</h3> —To investigate the speed of the transfer of new statistical methods into the medical literature and, on the basis of current data, to predict what methods medical journal editors should expect to see in the next decade. <h3>Design.</h3> —Influential statistical articles were identified and the time pattern of citations in the medical literature was ascertained. In addition, longitudinal studies of the statistical content of articles in medical journals were reviewed. <h3>Main Outcome Measures.</h3> —Cumulative number of citations in medical journals of each article in the years after publication. <h3>Results.</h3> —Annual citations show some evidence of decreasing lag times between the introduction of new statistical methods and their appearance in medical journals. Newer technical innovations still typically take 4 to 6 years before they achieve 25 citations in the medical literature. Few methodological advances of the 1980s seem yet to have been widely cited in medical journals. Longitudinal studies indicate a large increase in the use of more complex statistical methods. <h3>Conclusions.</h3> —Time trends suggest that technology diffusion has speeded up during the last 30 years, although there is still a lag of several years before medical citations begin to accrue. Journals should expect to see more articles using increasingly sophisticated methods. Medical journals may need to modify reviewing procedures to deal with articles using these complex new methods. (<i>JAMA</i>. 1994;272:129-132)
Tetracycline and blood urea.
Journal: BMJ (1972)

Tetracycline and Blood Urea Drugs of the tetracycline group cause a rise of blood urea.1 2 Patients with stable chronic renal failure may be precipitated into terminal renal failure when they are treated with these antibiotics.Drugs of the tetracycline group can produce a rise in the blood urea of people with normal kidneys.M. E. Shils3
Report of the Librarian
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1955)

THE Librarian herewith presents his annual report, the seventeenth accounting of the state of the Library since he took office in 1938. The report covers the calendar year 1954, another year of increased attendance, indicating an upward trend of usefulness in the period since the end of World War II. The circulation figure was slightly less than in 1953, but above the previous three years. The volumes at the end of 1954 numbered 224,477, and the catalogued pamphlets, 158,481. The accessions in books were 2,165, and those in pamphlets 1,896. The periodicals and serials currently received were 1,042. In general . . .
Abstract 16781: Dyssynchronous Ca Removal in Atrial Cardiac Myocytes From Failing Hearts
Authors: Felix Hohendanner, Frank R Heinzel, Lothar A Blatter
Journal: Circulation (2015)

In heart failure atrial remodeling (AR) leads to impaired contractility and relaxation as well as, atrial fibrillation and contributes to negative clinical outcomes. In myocytes cytosolic Ca removal after systolic release is primarily achieved by SERCA pump and Na/Ca exchange (NCX) activity, allowing atrial relaxation. In atrial myocytes that lack a transverse tubule system, NCX is located exclusively in the cell periphery where it is exposed to high concentrations of Ca during the cardiac cycle. Previously we found that the relative contribution of NCX to Ca removal was increased in AR and was associated with a higher propensity of arrhythmogenic Ca waves, i.e. Ca waves that triggered action potentials (APs). We hypothesize that dyssynchrony of Ca removal globally (whole cell) and locally (peripheral subsarcolemmal (SS) and central (CT) domains) is responsible for impaired relaxation and increased arrhythmogenicity. We used confocal line scan imaging and Ca sensitive dyes (Fluo-4/AM) to investigate Ca removal in remodeled atrial myocytes from a rabbit left ventricular volume-pressure overload systolic heart failure model. In control atrial myocytes Ca removal (assessed by the time constant of decay (TAU) of local SS and CT AP-induced Ca transients) is faster in the cell center (CT region) compared to the SS domain (342±32 vs. 393±31 ms, n=10 cells). In AR myocytes however, CT TAU was not different from SS TAU (196±11 vs. 190+14 ms, n=10 cells). In addition, in AR cells local dyssynchrony (defined as the standard deviation of TAU divided by mean TAU) in the CT domain was significantly increased compared to control (0.11±0.03 vs. 0.04±0.01, n=10 AR and CTRL cells). However despite the increased dyssynchrony, CT Ca removal was 50% and SS Ca removal 56% faster in AR myocytes as compared to control cells (n=10 AR and CTRL cells). In summary, AR myocytes show accelerated but dyssynchronous diastolic Ca removal that may result in impaired relaxation and increased susceptibility to rhythm disorders.
MEXICO CITY
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CONTROL OF PEPTIC ULCER
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
日光引发氧化应激中的皮肤类型差异
Authors: S. Albrecht, S. Jung, R. M€uller, J. Lademann, T. Zuberbier, L. Zastrow, C. Reble, I. Beckers, M.C. Meinke
Journal: British Journal of Dermatology (2019)

过多太阳光(日光)暴露, 尤其是紫外线辐射, 可能导致日晒伤和使细胞损伤加重(称为氧化应激)。这可能导致如炎症、皮肤早衰和肿瘤发生等皮肤损伤。来自美国国立癌症研究所的统计数据显示, 黑色素瘤和非黑色素瘤皮肤癌的新发病例数每年都在增加。因此,了解太阳光辐射在皮肤中的负面影响有重要意义。除了紫外线之外, 太阳光光谱中的可见和近红外区域可在白皙型皮肤中引发氧化应激, 但尚无关于在深色型皮肤中的影响数据。一项德国研究阐释了太阳光辐照过程深色皮肤的氧化应激分布, 并与白皙型皮肤的结果进行比较。将自由基作为氧化应激的标志物(即, 征象)。科学家们使用称为电子顺磁共振光谱的技术测量了太阳光辐照过程中志愿者的自由基形成情况。作者们发现, 深色皮肤防护紫外线辐照的能力优于白皙皮肤。但是, 深色型皮肤在近红外辐照过程中显示出的氧化应激显著高于白皙型皮肤。近红外中的氧化应激至少与紫外和可见光谱区域一样高,可能在深色皮肤中导致皮肤损伤。这些结果显示, 深色皮肤个体可能需要不同于浅色皮肤个体的日光防护类型, 以避免长期的太阳光辐照损伤。
Private Sector Volunteerism as a Solution to Caring for the Uninsured
Authors: Robert M. Reardon
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The first benevolent volunteers have already stepped forward in this phase of our health system revolution: the physicians.<sup>1</sup>To my knowledge, there are 175 free clinics now in operation in the United States. In Illinois in the last 2 years free clinics have opened in Bloomington, Peoria, Springfield, and Pontiac, among other areas, which help to make Illinois second in the country, after Virginia (oral communication, K. C. Kelleher, MD, January 20, 1995) in the number of free clinics. In addition to physicians volunteering their time and effort, corporate America has volunteered: in Bloomington we opened only because of the financial support of a national insurance company. Other companies, including drug companies, have supported our efforts not only with money, but also gifts in kind. Finally, the Illinois State Medical Society forgoes the annual Christmas party and instead donates the money to various free medical clinics
Ceruloplasmin
Authors: H. J. Van Peenen
Journal: Annals of Internal Medicine (1993)

Ad Libitum15 January 1993CeruloplasminH. J. Van Peenen, MDH. J. Van Peenen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-2-199301150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Among the handful of ocular signs given as jewelson the day of our initiation—the opacities,pigments, iritides, cups—we best rememberthe only one we will never find, a ring.It tells this protein's absence. Multiple choicedesigned to ferret out what we know aboutzinc-collectors or haptoglobin would fail us butalways these blue vowels leap from thetreasure chest of memory. Sky-granted, the namecomes like a password to our tongues whenever liversscar or limbs leap into fits although none of us,thinking of it in diagnosis, proves its guilt.every ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1993Volume 118, Issue 2Page: 154KeywordsHaptoglobinsLiverMemoryProteinsScarsThoraxTongue ePublished: 15 August 2000 Issue Published: 15 January 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Elevated CK-MB levels in marathon runners
Authors: Majid Ali, Evalynne V. Braun, A. Olusegun Fayemi
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Siegel et al have demonstrated marked elevations of serum levels of creatine kinase MB (CK-MB) isoenzyme (up to 21 times the upper limit of normal) in marathon runners during the postrace period (1981;246:2049). They believed that the source of this isoenzyme in their subjects was skeletal muscle injury. Largely on the basis of negative technetium Tc 99m pyprophosphate scintigrams, they concluded that serum CK-MB in these runners does not arise from a myocardial source. While skeletal rhabdomyolysis does appear to be the principal source of CK-MB, another lesion that should be considered in this setting is ischemic injury to individual myocardial fibers; such injury may cause substantial leakage of CK-MB isoenzyme and may be reversible or irreversible (cardiac myocytolysis). Cardiac myocytolysis may be defined as disintegration of individual myocardial fibers unaccompanied by an inflammatory response. Ischemia resulting in myocytolysis may involve randomly distributed myocardial fibers during a
Climacteric flushing in a man.
Journal: BMJ (1983)

Climacteric flushing in a manHot flushes are accepted as the characteristic accompaniment of the menopause in women.Although reports of flushing in men after orchidectomy' 2 or administration of a gonadotrophin releasing hormone agonist3 suggest that testicular failure may also be associated with disturbed vascular activity, no objective study has been made of these attacks in men.We report the first measurement of vascular changes during such an attack in a man who developed disabling hot flushes after orchi- dectomy.
Table of Contents
Authors: Amy Swerdlin, Carol Berkowitz, Noah Craft, Takeshi Echigo, Minoru Hasegawa, Makoto Inaoki, Masahide Yamazaki, Shinichi Sato, Kazuhiko Takehara, Isil Kilinc Karaarslan, Gulsum Gencoglan, Taner Akalin, Fezal Ozdemir, Vered Molho-Pessach, Ruth Bargal, Yigal Abramowitz, Victoria Doviner, Arieh Ingber, Annick Raas-Rothschild, Zvi Ne'eman, Marsha Zeigler, Abraham Zlotogorski, Roni Dodiuk-Gad, Pavel Dyachenko, Michael Ziv, Ayelet Shani-Adir, Yehudit Oren, Saul Mendelovici, Jan Shafer, Bibiana Chazan, Raul Raz, Yoram Keness, Dganit Rozenman, Douglas Patton, Peter Lynch, Maxwell Fung, Nasim Fazel, Sacramento California, Jessica Risser, Zakiya Pressley, Carl Washington, Suephy Chen, Anna Liza, C Agero, Melissa Gill, Marco Ardigo, Patricia Myskowski, Allan Halpern, Salvador Gonza ´lez, New York, Eric Simpson, Michelle Hercher, Erika Hammarlund, Matthew Lewis, Mark Slifka, Jon Hanifin, Anthony Dixon, Mary Dixon, Appl Sci, John Dixon, Shaheen Oshtory, Narin Do, Anita Apisarnthanarax, Kevin Cooper, Howard Meyerson
Journal: Journal of the American Academy of Dermatology (2007)