tbuckley/cabot-search huggingface dataset:
Mitochondrial Toxicity of Phthalate Esters
Authors: Ronald L. Melnick, Carol M. Schiller
Journal: Environmental Health Perspectives (1982)

The effects of mono- and dibutyl phthalate and mono- and di(2-ethylhexyl) phthalate on energy-dependent K+ uptake, respiration rates, and succinate cytochrome c reductase activities of isolated rat liver mitochondria were evaluated. The energy-coupling processes, active K+ transport and oxidative phosphorylation, were affected most by di-n-butyl phthalate and mono(2-ethylhexyl) phthalate. Mono-n-butyl phthalate had a moderate effect on energy coupling and di(2-ethylhexyl) phthalate had no apparent effect. The potency of inhibition of succinate cytochrome c reductase activity was mono(2-ethylhexyl) phthalate greater than di-n-butyl phthalate greater than mono-n-butyl phthalate = di(2-ethylhexyl) phthalate. It is concluded that phthalate esters affect mitochondrial activities by altering the permeability properties of the inner membrane and by inhibiting succinate dehydrogenase activity.
This Week in &lt;emph&gt;JAMA&lt;/emph&gt;
Journal: JAMA (2008)

A Piece of My Mind"Although 'transfusion' is not mentioned in the Bible, the relevant passages warn about the consequences of eating blood."From "Listening to Leviticus." SEE PAGE 879 Medical News & PerspectivesA clinical trial testing a combination of 2 anticholesterol drugs (exetimibe/ simvastatin, or Vytorin) is embroiled in controversy after results revealed that the therapy failed to prevent progression of atherosclerosis.
Impact of sentinel lymph node biopsy on staging of early cervical cancer: Results of a prospective, multicenter study
Authors: F. Lecuru, A. Bats, P. Mathevet, D. Querleu, E. Leblanc, P. Morice, E. Darai, H. Marret, C. Collin, G. Chatellier, F. Gilaizeau
Journal: Journal of Clinical Oncology (2009)

CRA5506 Background: 10% to 15% of patients with pN0 early cervical cancer experience recurrences. This may be related either to nodes missed by the dissection or located outside the dissection field or to failed diagnosis of node metastases. The objective of this study was to measure the benefits from sentinel node (SN) detection in terms of nodes collected from unusual territories and of detected micrometastases and isolated tumor cells (ITCs). Methods: 145 patients who had stage Ia1-Ib1 epidermoid cancer or adenocarcinoma or adenosquamous cancer were included in a multicenter study (January 2005 - June 2007). Noninclusion criteria were age<18 years, pregnancy, and previous treatment. SNs were identified by combined technetium and blue-dye labeling in the pelvic and para-aortic territories. Slices were cut 200 μm apart. At each level, HES staining and labeling with anti-cytokeratin antibodies (AE1-AE3) were performed. SNs in an unusual territory were defined as SNs outside the ilio-obturator region. ITC was defined as size <0.2 mm, micrometastasis as size 0.2 to 2mm, and macrometastases as size >2 mm. The study was funded by the French National Institute of Cancer and reviewed by an IRB. Results: 17 patients were excluded for major protocol deviations, leaving 128 patients for the per protocol analysis. One or more SNs were detected in 98.4% of patients (95%CI, 94.4 to 99.9%). The 430 detected SNs were located as follows: external iliac, 80.5 %; common iliac, 8.6%; presacral and paraaortic, 5.5%; and parametrial, 4.9 %. SN detection identified at least one SN in an unusual territory in 48/128 (37.5%) patients. There were 26 positive SNs in 21(16.4%) patients of whom 8 (38%) had macrometastases, 7 (33%) micrometastases, and 6 (29%) ITCs. Of these 26 nodes, 7 (27%) were detected only by immunohistochemistry (6/128 patients: 4.6%). There was no false-negative No node metastases were found in 104/128 (81.2%) patients. Conclusions: SN detection supplied additional information in 39.8% of patients (51/128), either showing that drainage occurred via unusual pathways or detecting cancer spread via immunohistochemistry. Node dissection could have been avoided in the 104/128 patients with negative nodes, potentially decreasing treatment-associated morbidity. No significant financial relationships to disclose.
Optimal use of blood tests for assessment of thyroid function
Authors: D. V. Becker
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The American Thyroid Association (ATA) in 1990 and 1991 issued guidelines for use of laboratory tests in thyroid disorders.<sup>1,2</sup>These ATA position papers update previous recommendations because of the development and availability of improved thyrotropin (thyroid-stimulating hormone [TSH]) methods capable of clearly separating normal from subnormal serum TSH levels. The highly sensitive TSH assay constitutes a practical, useful, and significant laboratory advance in clinical thyroidology. There is agreement among thyroid specialists that measurement of serum TSH level, complemented by an appropriate free thyroxine (FT<sub>4</sub>) estimate, represents the best and most efficient combination of blood tests for diagnosis and follow-up of most patients with thyroid disorders. Currently in the investigation of thyroid disease there is a trend to replace a combination of tests (eg, total T<sub>4</sub>+ triiodothyronine resin uptake + FT<sub>4</sub>+ total T<sub>3</sub>+ TSH) by a discriminating single thyroid function test. This trend reflects
The 1991 Albert Lasker Medical Awards. Clusters of master control genes regulate the development of higher organisms
Authors: E. B. Lewis
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endotracheal Anesthesia
Authors: John R. Gordon
Journal: JAMA (1964)

Drs. Bamforth and Siebecker have performed a most useful service in revising and editing the late Dr. Gillespie's classic book. The 15 years which have followed the preceding edition have brought many advances in endotracheal anesthetic techniques. These are covered completely while little of Dr. Gillespie's pleasant writing style is lost. The editors constantly advise caution. On one occasion when they warn against "pumping" a potent anesthetic agent into a patient, they remind the reader "the bold anesthetist must remember it is the patient who takes all the risk." And again they make a plea for restraint in the use of stylets and emphasize that a stylet is required in few, if any, intubations. The book admittedly endorses methods found most useful in the editors' practices. Not unexpectedly some readers will find points of difference. For example, cocaine is their topical anesthetic of commonest choice. This may not sit well
Circulation Research, New York
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myositis-specific autoantibodies. Touchstones for understanding the inflammatory myopathies
Authors: F W Miller
Journal: JAMA (1993)

<h3>SELECTED CASE</h3> A 27-year-old stonemason, who was previously well, had acute onset of weakness, stiffness, and pain in the proximal arm, leg, and back muscles. A week later low-grade evening fevers, diffuse swelling of his extremities and face, and a bluish rash over his eyelids developed; 2 weeks after that, he noticed shortness of breath, dysphagia, and a thickening of his voice. During the next several days, his condition deteriorated rapidly, with increasing shortness of breath and cyanosis, and he died of a presumed pulmonary arrest. Autopsy showed firm, fluid-filled lungs, splenomegaly, and swollen proximal muscles; the distal muscles, eye muscles, and tongue muscles were spared. Histopathologic examination showed a focal round-cell infiltration permeating the interstitium of the affected muscles and muscle cells in various stages of degeneration. No microorganisms were seen. <h3>THE IDIOPATHIC INFLAMMATORY MYOPATHIES</h3> With the publication of this case over 100 years ago,<sup>1</sup>Professor Hans Unverricht
Institutional Outbreak of Hemolytic Streptococci (Scarlet Fever): Investigation and Report from the Bureau of Communicable Diseases, Los Angeles City Health Department
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2013)

The Women's Health Initiative (WHI) hormone therapy trials-which involved 27 347 postmenopausal women who were randomly assigned either to receive conjugated equine estrogen (CEE) plus medroxyprogesterone acetate (MPA) or placebo for a median of 5.6 years or to receive CEE alone (among women with hysterectomy) or placebo for a median of 7.2 years-investigated the benefits and risks of menopausal hormone therapy for chronic disease prevention.In this article, Manson and colleagues present a comprehensive overview of health outcomes during the cumulative 13-year (median) intervention and postintervention phases of the 2 trials.The authors report a complex pattern of risks and benefits associated with menopausal hormone therapy, which do not support its use for chronic disease prevention.Hormone therapy may be appropriate for menopausal symptom management in some women.In an Editorial, Nable discusses menopausal hormone therapy and women's health in the post-WHI era.
Undernutrition
Authors: Kenneth Kaplan
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Dr Bomgaars' lucid and concise report (236:2513, 1976) does indeed warrant editorial comment. However, important issues are raised besides those addressed by Dr Aring (236:2535, 1976). A concern of mounting importance to Nepal and other similar countries described in many other publications<sup>1-5</sup>is the impact of selective, mid 20th century technology on the few remaining totally nonindustrialized nations. Dr Bomgaars' article indicates that a major cause of infant and child mortality has been identified in Nepal, and a simple, culturally acceptable, and inexpensive means of correcting it exists. What must be dealt with in the next breath is the impact of this treatment on the social fabric of the country as life expectancy is prolonged and the population grows. Unless simultaneous attention is given to such widely diverse issues as food production and distribution, housing, fuel, land ownership and inheritance practices, immunization programs, water treatment and sewage
ACID INTOXICATION.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term liver fibrosis and outcomes in HCV-infected solid organ transplant recipients after DASSs-induced viral eradication
Authors: Chiara Manuli, Alberto Zanetto, Alberto Ferrarese, Sarah Shalaby, Salvatore Sciarrone, Monica Pellone, Giacomo Germani, Marco Senzolo, Patrizia Burra, Francesco Paolo Russo, Martina Gambato
Journal: Journal of Hepatology (2020)
Experimental Aspects of Tobacco Carcinogenesis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory Tract Changes in Guinea Pigs, Rats, and Mice Following a Single Six-Hour Exposure to Methyl Isocyanate Vapor
Authors: Edward H. Fowler, Darol E. Dodd
Journal: Environmental Health Perspectives (1987)

Groups of male and female Fischer 344 rats, B6C3F1 mice, and Hartley guinea pigs were exposed once for 6 hr to mean concentrations of 10.5, 5.4, 2.4, 1.0, or 0 (control) ppm of methyl isocyanate (MIC) vapor. Rats and mice were also exposed to 20.4 ppm of MIC. The majority of deaths occurred during postexposure days 1 through 3. The 6-hr LC50 values (with 95% confidence limits) were 6.1 (4.6 to 8.2) ppm for rats, 12.2 (8.4 to 17.5) ppm for mice, and 5.4 (4.4 to 6.7) ppm for guinea pigs. Notable clinical observations during and immediately following MIC exposure were lacrimation, perinasal/perioral wetness, respiratory difficulty (e.g., mouth breathing), decreased activity, ataxia, and hypothermia. Body weight losses were common in all species following MIC exposures of 2.4 ppm or greater. Microscopic lesions included acute necrosis of the epithelial lining throughout the respiratory tract in animals that died shortly after exposure, coupled with congestion, edema, and inflammation. A microscopic lesion that appeared unique to guinea pigs was bronchiolitis obliterans (where the products of necrosis and inflammation completely closed the bronchioles). Additional microscopic lesions observed in some animals that died or were sacrificed at the end of the study (postexposure day 14) consisted of squamous metaplasia of respiratory epithelium in the nasal cavity, which extended into the larynx, trachea, and in some cases, the bronchi.(ABSTRACT TRUNCATED AT 250 WORDS)
Matricellular protein CCN3 mitigates abdominal aortic aneurysm
Authors: Chao Zhang, Dustin van der Voort, Hong Shi, Rongli Zhang, Yulan Qing, Shuichi Hiraoka, Minoru Takemoto, Koutaro Yokote, Joseph V. Moxon, Paul Norman, Laure Rittié, Helena Kuivaniemi, G. Brandon Atkins, Stanton L. Gerson, Guo-Ping Shi, Jonathan Golledge, Nianguo Dong, Bernard Perbal, Domenick A. Prosdocimo, Zhiyong Lin
Journal: Journal of Clinical Investigation (2016)
BOOK REVIEWS
Authors: M. TERPENNING
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access The Chemotherapy Source Book Michael C. Perry , ed. Baltimore : Williams & Wilkins , 1992 . 1172 pp., illus. $130. ISBN 0-683-06859-8 MARILOU TERPENNING MARILOU TERPENNING UCLA School of Medicine2336 Santa Monica Blvd., ♯301 Santa Monica, CA 90404 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 13, 1 July 1992, Pages 1042–1043, https://doi.org/10.1093/jnci/84.13.1042 Published: 01 July 1992
Invertebrate Learning and Memory: From Behavior to Molecules
Authors: T. Carew
Journal: Annual Review of Neuroscience (1986)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
The Jacket of Japanese Bamboo.—
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Milroy Lectures ON THE HYGIENIC ASPECT OF THE COAL-MINING INDUSTRY IN THE UNITED KINGDOM: Delivered before the Royal College of Physicians of London
Authors: F. Shufflebotham
Journal: BMJ (1914)

I~~~~~~~~~~~~~~~~~~~~MEDICAL JOURNAL 70 for " drink,".an.d more especially if the probatioln officer is both judiciouLs and zealous, the man, after the first week of lhospital treatment, mlay be permitted to continue the treatment in the form of office treatment.We find that the great majority of the cases tllat come under our care can be satisfactorily treated as office patients.Tllis is less expensive than hiospital treatmelnt, and lhas enabled us to reaclh a ilmuclh larger number than wouold have been possible otlherwise.W\!ith the office treatment the lhypodermic injections of stryclhnine and apomorphine are olmitted.Eitlher tlle calomel and salts treatment, or a laxative of some sort is giveni at the outset, and tlhe bowels liept loose for a few dlays.The medical treatment proper is commenced witl thie following mixture: Tincture of capsicum, 1 draclhm; tiin-cture of ignatia (or nux vomica), 1UL drachms; water, 8 oz.Dose, a tables;poonfuil every liour wlhile awake.After ten days this nmixture is changed to the following: Fluid extract of quassia, 2 draclhms, and tincture of ignatia (or nux vomiica), 11 drachms; water, 8 oz.Dose, a tablespoonful every hlour while awake.This mixture is continued until the end of the tlhird week of treatment.The patient calls for treatment every day during the first week, every second day during tlle second week,and every tlilrd day during the tlhird week.After this he is seen occasionally by the probation officer, wlho is expected to lieep in touclh witlh the case as long as possible, and especially so if the trouble is periodic.Whlile, with our treatment, the crave for drink is relieved in less than tliree weeks, we do not claim that this crave is removed permanently.Some of our cases go for years witlhout meaking a break, wlhile others miake a break in a few monthis.We warn periodical cases to return in good time for prophvlactic treatmient.We have oni our list a few cases tlait require to be nursed in this manner.Between times they are respectable, and supporters of their families.Some of themn go for maany montlhs without making a break.Our treatment is a tonic for the nerve centres, and leaves the patient wonderfully improved in lhealtlh and strengtl, wNitlh good appetite and good digestion.In some cases, for convenience sake, I sormetimes give