tbuckley/cabot-search huggingface dataset:
Is nudge an effective public health strategy to tackle obesity? Yes
Authors: A. Oliver
Journal: BMJ (2011)

Users of single-use (SU) components need extractables data to demonstrate material safety for regulatory bodies before incorporation in the biopharmaceutical process. In this context, the correct use of such extractables data is key to deriving realistic risk assessments for SU devices. In this paper, a standardized extractables approach was used that provides comprehensive extractables information including identity and quantity. The combination of extractables data obtained from different components of a sterile filter capsule, such as the filter cartridge and housing, and the scaling thereof is presented. A sterile filter type including polyethersulfone membrane was extracted with pure water and pure ethanol at 40°C for 24 h. The organic extractables were identified and their concentration quantified using state-of-the-art analytical methods such as gas chromatography–mass spectrometry for semivolatile compounds together with headspace sampling for volatile compounds, and liquid chromatography coupled with high-resolution mass spectrometry. The extractables detected were assigned to the materials of filter construction. The evaluation showed that the extractables quantities per device depended on the surface areas of the contact materials, such as the filter membrane, and also on the plastic parts. This paper confirms the validity of a so-called component approach and a scaling concept to calculate extractables data for SU filters of different sizes with short-term contact. <i>LAY ABSTRACT:</i> In the biopharmaceutical industry, a large number of SU system combinations with a variety of different sizes are used. Suppliers of such diverse SU systems and assemblies cannot perform extraction studies for all of the different configurations and sizes individually. It is acceptable in this industry to use component approaches and scaling concepts to provide extractables data for SU systems and assemblies derived from a dedicated extraction experiment. This paper shows the applicability of a so-called component approach and of a scaling concept to calculate extractables data for sterile polyethersulfone membrane filters and filter capsules of different sizes. Selected extraction conditions allow scaling calculations according to underlying physical principles. The extractions were performed under short-term contact, for example, 24 h, to ensure that the release of extractables was diffusion-controlled. The results demonstrated that extractables quantities depend on the surface area of the contact material. Membrane-related compounds were scalable with the membrane area, whereas polypropylene (PP)-related compounds were scalable with the PP contact area.
The Etiology Of Mental Deficiency With Special Reference To Its Occurrence In Twins : A Chapter In The Genetic History Of Human Intelligence. By<i>A. J. Rosanoff, L. M. Handy, and I. R. Plesset</i>. Psychological Monographs, Vol. XLVIII, No. 4. (Princeton: Psychological Review Publications, 1937.)
Journal: American Journal of Psychiatry (1937)
DEFINITION OF ALLERGIC DISEASES
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for Heterozygous α1-Antitrypsin Deficiency
Authors: Jack Lieberman
Journal: JAMA (1971)

Diethylstilbestrol caused serum trypsin-inhibitory capacity (STIC) values to rise into the low-normal range in most studied heterozygotes with α<sub>1</sub>-antitrypsin deficiency, but never above 1.20 units; in control subjects, the stimulated STIC values exceeded 1.30 units. Subjects with homozygous antitrypsin deficiency did not respond to diethylstilbestrol. Lack of response to 3 mg of diethylstilbestrol daily for two weeks in a patient with 1.20 units or less of antitrypsin activity indicates that the patient's antitrypsin level is already maximally stimulated by his disease, and confirms a dagnosis of heterozygous α<sub>1</sub>-antitrypsin deficiency. Women receiving oral contraceptive medication or other estrogenic hormones whose random antitrypsin assay shows a level of 1.20 units or less should be suspected of carrying the abnormal gene for antitrypsin deficiency.
Effect of temperature upon caraniocerebral trauma. An experimental study in dogs
Authors: W. F. Bouzarth
Journal: JAMA (1967)

Severe mechanical trauma to the brain is associated with a high rate of morbidity and mortality. Vigorous treatment must be started immediately if the patient's prognosis is to be improved. Recently, Rosomoff and co-workers<sup>1</sup>revived interest in hypothermia as a therapeutic tool by their experimental observations on animals. Lazorthes and Campan,<sup>2</sup>in France, were able to reduce mortality rates in human patients by artificial hibernation, and this technique has become an acceptable adjunct to the treatment of brain injury.<sup>3</sup> In 1961, one of us (W.F.B.) began to treat every patient having severe brain injury with immediate hypothermia. Surface cooling was started in the emergency room to reduce the rectal temperature to 87.8 F (31 C) within 90 minutes. Of 14 consecutive patients, ten harbored subdural hematomas. This was a much higher incidence than reported in a larger series<sup>4</sup>not treated with hypothermia. In addition, hyperthermia was
Hepatocyte growth factor-scatter factor expression in myeloic and B-lymphocytic cells suggests paracrine stimulation of liver regeneration by inflammatory cells . Institute of Pathology and Medical Clinic III, Div. of Hematology, Univ. of Mainz, Germany
Journal: Hepatology (1995)

The expression of c-myb mRNA and protein was analyzed in fresh leukemic cells by Northern-blot analyses and by immunofluorescent staining using monoclonal c-myb specific antibodies. Staining of the cells was evaluated by flow cytometry. The results demonstrate c-myb mRNA expression predominantly in acute lymphocytic leukemia (ALL, 4/4 cases), acute myeloic leukemia (AML, 1717) and chronic myeloic leukemia (CML, 1212) but rarely in chronic lymphocytic leukemia (CLL, 117). Immunofluorescent analyses revealed expression of c-myb protein in the nucleus of ALL (57) and AML (99) with a good correlation of c-myb-positive cells and with the number of proliferating (Ki67-positive) blast cells.
OPHTHALMO-TOXIC REACTIONS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessment of the Propensity for Covalent Binding of Electrophiles to Biological Substrates
Authors: Robert M. Carlson
Journal: Environmental Health Perspectives (1990)

Electrophilic character is associated with the ability of external agents to interact with centers of electron density in biological macromolecules and to cause the interruption or alternation of normal activity. With the observation of site specificity in mutagenic events. Pearson's hard/soft acid-based (HSAB) theory is presented as a useful concept in correlating chemical observations in the absence of detailed direct knowledge of the process. Methods for the evaluation of carbon electrophiles (e.g., carbocation character) as reactants are reviewed as potential physical parameters that could be applied in developing quantitative structure-activity relationships.
The Clinical Spectrum of Multiple Endocrine Neoplasia Type 2a Caused by the Rare Intracellular RET Mutation S891A
Authors: Klaus-Martin Schulte, Andreas Machens, Laura Fugazzola, Alan McGregor, Salvador Diaz-Cano, Louise Izatt, Simon Aylwin, Nadia Talat, Paolo Beck-Peccoz, Henning Dralle
Journal: Endocrine Reviews (2010)

Germline missense mutations of the RET protooncogene cause a clinical spectrum called multiple endocrine neoplasia (MEN) type 2. A strong genotype-phenotype correlation results in major implications for the clinical approach. More information on less common mutations is needed to advance specific guidance. We report individualized patient information on 36 carriers of the intracellular RET gene mutation S891A from three centers and clustered data of 38 former patients reported in the literature in nine additional studies. S891A mutation accounts for up to 5% of all patients to date reported with RET mutations and 16% of those hitherto reported with intracellular mutations. S891A mutation caused medullary thyroid cancer (MTC) in 69.4%, pheochromocytoma in 2.8%, and parathyroid hyperplasia in 8.3% of the 36 patients of this case series and in 63.5, 4.1, and 4.1%, respectively, for the entire groups of 74 patients. The youngest age of onset for MTC in this group was 17 yr (median, 46 yr; range, 17–80 yr), for pheochromocytoma 46 yr (median, 46 yr), and for parathyroid hyperplasia 17 yr (median, 20 yr, range, 17–46 yr). Persistence of MTC was described in 14.3% of patients with available follow-up. Additional findings included corneal nerve thickening in three of 74 patients (4.1%). This intracellular mutation can initiate the full spectrum of MEN2a, initiates MTC at an early age, and causes recurrence and death if undertreated. We recommend stringent adherence to established guidance in MEN2a in this rare mutation.
Death Rituals
Authors: Ruth Lerman
Journal: Annals of Internal Medicine (2003)

On Being a Doctor2 September 2003Death RitualsRuth Lerman, MDRuth Lerman, MDFrom William Beaumont Hospital; Royal Oak, MI 48073-6769.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-5_Part_1-200309020-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It turned out that Dr. Ernst, the medical resident who came to declare my father dead, had known him. A few years prior, Dr. Ernst had done his medical student clerkship in family practice at my father's office. My mother worked there too. He had recognized my mother when he entered the room on the hospital's 7th floor oncology ward. My brother, my mom, and I were all there. It was mid-day. My dad had just died.The wings of Dr. Ernst's unbuttoned white coat flew open as he strode purposefully into the room. He was wearing a white button-down ... Author, Article, and Disclosure InformationAuthors: Ruth Lerman, MDAffiliations: From William Beaumont Hospital; Royal Oak, MI 48073-6769.Corresponding Author: Ruth Lerman, MD, William Beaumont Hospital, Imaging Center, 3601 West Thirteen Mile Road, Royal Oak, MI 48073-6769; e-mail, rlerman@beaumont.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPreparation of residents for death pronouncement: A sensitive and supportive methodDeath Pronouncements: Using the Teachable Moment in End-of-Life Care Residency Training 2 September 2003Volume 139, Issue 5_Part_1Page: 384KeywordsChildrenDo not resuscitate ordersHeartHematology and oncologyMemoryPharynxResidencyRibsSleepThorax ePublished: 2 September 2003 Issue Published: 2 September 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Seattle Health Officer.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Victor Sidel, MD: builder of bridges
Authors: P. Gunby
Journal: JAMA (1982)

Harvard's 1957 medical class gathers in Boston for its 25th reunion a week from today, and the lead-off speaker is expected to leave these now middle-aged physicians with plenty to ponder. And then the energetic speaker will hurry off—not back to the Bronx, NY, where he has lived and worked for 13 years, but rather to begin a journey more than halfway around the world. Almost before the day is over, Victor W. Sidel, MD, will arrive in the People's Republic of China for his fifth visit. Thus June 11 hardly will be a typical day—even for Sidel—at least in terms of scheduling. But it will typify his past, present, and possibly future activities in areas of social concern. These days, Sidel, who is professor and chairman, Department of Social Medicine, Montefiore Hospital and Medical Center, Albert Einstein College of Medicine, usually is identified with the ideas that he espouses
BOOK REVIEW
Authors: A. MOLITERNO
Journal: JNCI Journal of the National Cancer Institute (1994)

BOOK REVIEW Get access Hematology: Pathophysiologic Basis for Clinical Practice, Third Edition Stephen H. Robinson , Paul R. Reich , eds. Boston : Little, Brown , 1993 . 460 pp., illus. $35.95. ISBN 0-316-73864-6 ALISON MOLITERNO, M.D. ALISON MOLITERNO, M.D. Special Hematology, Johns Hopkins HospitalBlalock 1036, 600 N. Wolfe St., Baltimore, MD 21287-4928 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 2, 19 January 1994, Page 146, https://doi.org/10.1093/jnci/86.2.146 Published: 19 January 1994
Study of the effects of paf‐acether on human nasal airways
Authors: E. Leggieri, A. Tedeschi, M. Lorini, A. Bianco, A. Miadonna
Journal: Allergy (1991)

In 6 normal subjects and 6 patients with allergic rhinitis, nasal response to insumation of paf‐acether (paf, platelet‐activating factor), lyso‐paf and histamine was evaluated. Nasal challenge with paf, at doses of 300 and 600 nM, induced nasal obstruction, associated with an increase in nasal airway resistances, measured by antherior passive rhinomanometry. Maximum increase in nasal airway resistance was observed at 30 min after challenge (mean percent change + 481 with 600 nM paf; P &lt; 0.05). Other symptoms induced by paf insumation were rhinorrhea (6 out of 12 subjects), itching (8 out of 12), sneezing (4 out of 12) and a burning sensation (6 out of 12). No differences were observed between normal and rhinitic subjects, concerning nasal sensitivity to paf. Neither nasal symptoms nor changes in nasal airway resistance were observed after nasal challenge with lyso‐paf (300 and 600 nM); by contrast, histamine (100 nM) induced sneezing, nasal obstruction, itching and rhinorrhea in all the studied subjects, associated with an increase in nasal airway resistance (maximum 5 min after challenge; percent change + 358; P &lt; 0.02). Nasal effects of paf were not mediated by histamine, since no increase in histamine levels was observed in nasal washings following paf insufflation. We conclude that paf may have pathogenetic relevance in allergic rhinitis.
<i>Atlas of Clinical Medicine.</i> By Byroh Bramwell, M. D., F. R. C. P., Edin.; F. R. S., Edin.; Assistant Physician to the Edinburgh Royal Infirmary, etc., etc. Vol. I, Parts III and IV. Edinburgh: Printed by T. &amp; A. Constable, at the University Press
Authors: A. M.
Journal: American Journal of Psychiatry (1892)
THE EFFECTS OF UNDERNOURISHMENT
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERRATUM
Journal: American Journal of Hematology (1999)

Due to misinterpretation of sequence data, the mutation in the PIG-A gene described in the text and Figure 4 was incorrect.The reported mutation, a deletion of a guanine at the end of exon 2 should be changed to a base substitution from guanine to adenine with an amino acid change form Gly to Arg.The authors regret the error.
OC-052 Assessment of novel genetic polymorphisms and risk of upper gastrointestinal carcinoma
Authors: G Hold, E El-Omar, W Chow, H Risch, M Gammon, T Vaughan, J Lissowska, P Lochhead, C Rabkin, M Ng
Journal: Gut (2010)

<h3>Introduction</h3> Upper gastrointestinal malignancies comprising gastric and oesophageal cancers remain a major global health problem. Recently, genome wide association studies have been used to identify risk factors for several diseases. Four SNPs identified at chromosome regions 8q24 and 9p24 (rs6983267, rs10505477, rs1447295 and rs719725) have been shown to increase risk of various solid tumours including prostate and colorectal cancer, but have not been studied in the context of upper GI cancer. <h3>Methods</h3> Two case-control studies were used to assess SNP frequency: Study 1- a gastric cancer case-control study derived from a Caucasian population in Warsaw, Poland with DNA available from 312 non-cardia gastric adenocarcinoma patients and 419 controls, Study 2- a multicentre oesophageal and gastric cancer study from the US with DNA available from 307 subjects with gastric adenocarcinoma, 159 subjects with oesophageal cancer and 211 population controls. DNA was genotyped by 5′ nuclease PCR assay. Hardy-Weinberg equilibrium of alleles at individual loci was assessed using χ<sup>2</sup> test. OR with Cornfield 95% CIs were computed by logistic regression using Stata V.7.0 software. <h3>Results</h3> Genotyping and statistical analysis of the 4 SNPs was completed on 765 cases and 583 controls. Individuals carrying the C/C genotype of rs1447295 had an elevated risk for non-cardia gastric cancer (OR 1.57, 95% CI 1.03 to 2.45). Individuals carrying the A/A genotype of rs1447295 had an increased risk of squamous cell oesophageal cancer (OR 7.4, 95% CI 1.4 to 49). None of the other three SNPs tested in this study showed any statistically significant associations. <h3>Conclusion</h3> The association between the rs1447295 SNP and risks of gastric and oesophageal cancer are novel and offer an opportunity to explore the genetic basis of these malignancies. Our study has extended the genetic link between the 8q24 region and risk of yet another group of solid tumours. Extensive efforts should focus on evaluating the functional significance of this region in the context of the molecular pathogenesis of these malignancies.
Erratum
Journal: JNCI Journal of the National Cancer Institute (1976)

In “Ultrastructural Studies of Surface Features of Human Normal and Tumor Cells in Tissue Culture by Scanning and Transmission Electron Microscopy” by Matthew A. Gonda, Stuart A. Aaronson, Nelson Ellmore, Victor H. Zeve, and Kunio Nagashima, please note the following correction: Page 245, column 2, paragraph 2, lines 2 and 3 should read “… 0.5× Dulbecco's phosphate-buffered saline and 0.05 m sodium cacodylate…”) not “… 0.05× Dulbecco's phosphate-buffered saline and 0.5 m sodium cacodylate …”).
Deutscher Bäderkalender.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal