tbuckley/cabot-search huggingface dataset:
Cancer Screening
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annual Report of the Supervising Surgeon=General of the Marine= Hospital Service of the United States for the Fiscal Year 1894.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P337: Dietary Intakes of Rice, Bread, Pasta, Potatoes and Blood Pressure: The International Study of Macro/Micro-nutrients and Blood Pressure (INTERMAP)
Authors: Masaru Sakurai, Linda M Oude Griep, Martha Daviglus, Danniel B Garside, Linda V Van Horn, Katsuyuki Miura, Hideaki Nakagawa, Hirotsugu Ueshima, Queenie Chan, Paul Elliott, Jeremiah Stamler
Journal: Circulation (2013)

Background: Previous population-based cross-sectional studies have reported modest inverse relations of dietary starch intake and blood pressure (BP). However, studies that have evaluated associations of BP with starchy foods, e.g., rice, potatoes, pasta, bread, are limited. Objective: Data from INTERMAP were used to assess relations between consumptions of starchy foods and BP. Methods: INTERMAP is a cross-sectional epidemiologic study of 4,680 persons ages 40 to 59 years from 17 random population samples in China, Japan, United Kingdom (UK), and United States of America (USA). BP was measured 8 times; data on food and supplement use were obtained from 4 standardized in-depth multi-pass 24-hour dietary recalls and 2 timed 24-hour urine collections. Differences in BP for each food intake higher by two standard deviations (SD) were estimated by multivariable linear regression (2 SD values: rice: 177, pasta: 56, potatoes: 65, bread: 40, sum of these four: 177 g/1,000 kcal). Adjustment for possible confounders was performed sequentially; for age, gender, sample; plus dietary and other lifestyle factors. Results: Rice intake higher by 2SD was associated with systolic/diastolic BP differences of -1.38 /-0.79 mm Hg (p &lt;0.05 and p = 0.08) adjusted for age, gender, and sample. After further adjustment for dietary and other lifestyle factors, these associations were attenuated to -0.36 mm Hg for systolic BP (p = 0.61) and -0.28 mm Hg for diastolic BP (p = 0.55). Cross-country heterogeneity was detected for the associations between rice intake and systolic BP: inverse for Japan, China, and USA; direct for UK. Consumption of other starchy foods were not significantly associated with BP. After adjustment for age, gender, and sample, 2SD difference for the sum of these 4 starchy foods was associated with significant systolic/diastolic BP differences of -1.17/-0.84 mm Hg (p &lt;0.05 for both); associations were not significant with adjustment for dietary and other lifestyle factors. Conclusions: Modest inverse associations were observed with BP and intake of rice and the sum of the four most common starchy foods in four countries. Higher consumption of these starchy foods may contribute modestly to lower blood pressure levels in other populations, and thereby potentially confer preventive benefits regarding hypertension and cardiovascular disease.
Abstract 3635: RNA-based nanostructures for therapeutic siRNA delivery
Authors: Yonggang Ke, DongMoon Shin, Georgia Chen
Journal: Cancer Research (2019)

Abstract Short interfering RNA (siRNA) has emerged as a promising molecular therapeutic tool for targeted cancer treatment. However, systemically administered siRNA has demonstrated only limited success, due to limited delivery to cancer cells. Therefore, the lack of a robust and versatile siRNA delivery system is a critical issue in translating this therapeutic tool for cancer treatment. Recent developments in DNA nanotechnology have made programmable DNA nanoparticles (DNPs) a potent drug delivery platform. This study focuses on the development of a novel RNA-based siRNA delivery system to knockdown Bcl2 gene, as a targeted cancer therapeutic. By eliminating the use of DNA, the RNA-based nanodelivery can potentially create more robust siRNA delivery vehicles for targeted cancer therapeutics. Citation Format: Yonggang Ke, DongMoon Shin, Georgia Chen. RNA-based nanostructures for therapeutic siRNA delivery [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3635.
Jamarsan Paint
Authors: G. G. Liddle
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The dermatologic profession contributes the most glorified latinized names for diseases, disappearing from other specialties, but honored in medieval splendor among the skin men. It also contributes some of the more lavish formulas for materials to be applied to the skin. Roaming through a library of expanding and pulsating dermatologic articles, I encountered Jamarsan paint. My investigation of its introduction to dermatologists showed it to be of truly American origin, but from below the equator, named for its inventor, Isadore Jamar, a whilom medical student and pharmacognosist, who produced the formula (in grams): The coal tar is black, and so is the result, and so is the patient after application. The oil serves as vehicle, and the turpentine heightens the aroma, because one function of Jamarsan paint is to deodorize smelly skin. The lime thickens it, and the boric acid keeps germs from growing beneath it. The
Peanut Allergy
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
British Association of Dermatologists Seventy-Second Annual Meeting, 1992, Bournemouth
Journal: British Journal of Dermatology (1992)

British Journal of DermatologyVolume 127, Issue s40 p. 5-12 British Association of Dermatologists Seventy-Second Annual Meeting, 1992, Bournemouth First published: July 1992 https://doi.org/10.1111/j.1365-2133.1992.tb01234.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume127, Issues40July 1992Pages 5-12 RelatedInformation
Eye banking.
Authors: T A Casey
Journal: BMJ (1984)

the M negative twin pairs had a greater environmental source of variance operating than M positive pairs.2The advent of gene probes to detect DNA polymorphic variation (gene deletions, mutations, and so on) will permit the twin method to explore the quantitative aspects of gene- environment interaction in great detail.Although there has been criticism of relying on the use of the twin method alone in studying behaviour,1 these criticisms are probably not as valid in medical research where physical and chemical measurements are being made.
Serious Liver and Metabolism Problems Associated with Use of the Anti-HIV Drug Stavudine
Journal: Annals of Internal Medicine (2000)

Summaries for Patients1 August 2000Serious Liver and Metabolism Problems Associated with Use of the Anti-HIV Drug StavudineSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-3-200008010-00030 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Fatty infiltration of the liver (hepatic steatosis) combined with high levels of a certain type of acid (lactic acidosis) is an uncommon but potentially fatal combination of complications that has been reported with use of the anti-HIV drugs didanosine and zidovudine. Stavudine, one of the most commonly used anti-HIV medicines, has rarely been associated with these complications.Why did the researchers do this particular study?To describe the medical history of four patients who developed hepatic steatosis and lactic acidosis while taking stavudine.Who was studied?Four patients ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Lactic Acidosis and Hepatic Steatosis Associated with Use of Stavudine: Report of Four Cases.” It is in the 1 August 2000 issue of Annals of Internal Medicine (volume 133, pages 192-196). The authors are K.D. Miller, M. Cameron, L.V. Wood, M.C. Dalakas, and J.A. Kovacs.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLactic Acidosis and Hepatic Steatosis Associated with Use of Stavudine: Report of Four Cases Kirk D. Miller , Miriam Cameron , Lauren V. Wood , Marinos C. Dalakas , and Joseph A. Kovacs Metrics 1 August 2000Volume 133, Issue 3Page: 192KeywordsBloodComputed axial tomographyDrugsEnzymesFatty liverLactic acidosisLiverMusclesPancreasSteatosis ePublished: 15 August 2000 Issue Published: 1 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
U.S. Cancer Mortality 1950-1978: A Strategy for Analyzing Spatial and Temporal Patterns
Authors: Kenneth G. Manton, Eric Stallard, John P. Creason, Wilson B. Riggan
Journal: Environmental Health Perspectives (1985)

There are a number of technical and statistical problems in monitoring the temporal and spatial variation of local area death rates in the United States for evidence of systematically elevated risks. An analytic strategy is proposed to reduce one of the major statistical concerns, i.e., that of identifying areas with truly elevated mortality risks from a large number of local area comparisons. This analytic strategy involves two stages. The first is a procedure for examining the entire distribution of local area death rates instead of simply selecting high risk "outliers." The second is the development of an analytic procedure to relate the temporal changes in the cross-sectional distribution of local area death rates to models of the disease process operating within the populations in those areas. The procedures are applied to data on cancer mortality for the 3050 counties (or county equivalents) of the United States over the period 1950 to 1978. A number of striking mortality patterns, both within the entire United States and within various regions and states, are identified. For example, perhaps the most persistent finding was that the risk increases in the death rates for respiratory cancer mortality were due to a "catching up" of nonmetropolitan county mortality rates with metropolitan area mortality rates.
Late Breaking Abstracts: Presented at the American Society of Gene & Cell Therapy's 16thAnnual Meeting, May 15–18, 2013, Salt Lake City, Utah
Journal: Molecular Therapy (2013)

Late Abstracts Poster Session I: Thursday, May 16, 2013, Oral Abstract Session 230, 2:00 pm – 4:00 pm, Room: Ballroom A, Clinical Gene & Cell Therapy
Anaplastic Thyroid Cancers Harbor Novel Oncogenic Mutations of the <i>ALK</i> Gene
Authors: Avaniyapuram Kannan Murugan, Mingzhao Xing
Journal: Cancer Research (2011)

Abstract Thyroid cancer is the most common endocrine cancer, and targeted approaches to treat it pose considerable interest. In this study, we report the discovery of ALK gene mutations in thyroid cancer that may rationalize clinical evaluation of anaplastic lymphoma kinase (ALK) inhibitors in this setting. In undifferentiated anaplastic thyroid cancer (ATC), we identified two novel point mutations, C3592T and G3602A, in exon 23 of the ALK gene, with a prevalence of 11.11%, but found no mutations in the matched normal tissues or in well-differentiated thyroid cancers. These two mutations, resulting in L1198F and G1201E amino acid changes, respectively, both reside within the ALK tyrosine kinase domain where they dramatically increased tyrosine kinase activities. Similarly, these mutations heightened the ability of ALK to activate the phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein (MAP) kinase pathways in established mouse cells. Further investigations showed that these two ALK mutants strongly promoted cell focus formation, anchorage-independent growth, and cell invasion. Similar oncogenic properties were observed in the neuroblastoma-associated ALK mutants K1062M and F1174L but not in wild-type ALK. Overall, our results reveal two novel gain-of-function mutations of ALK in certain ATCs, and they suggest efforts to clinically evaluate the use of ALK kinase inhibitors to treat patients who harbor ATCs with these mutations. Cancer Res; 71(13); 4403–11. ©2011 AACR.
Book Review Infant and Child in the Culture of Today: The guidance of development in home and nursery school . By Arnold Gesell, M.D., and Francis L. Ilg, M.D. In collaboration with Janet Learned, M.A., and Louise B. Ames, Ph.D. 4°, cloth, 399 pp. New York and London: Harper and Brothers, 1943. $4.00.
Journal: New England Journal of Medicine (1943)
Significance of DNA Adduct Studies in Animal Models for Cancer Molecular Dosimetry and Risk Assessment
Authors: Frederick A. Beland, Miriam C. Poirier
Journal: Environmental Health Perspectives (1993)

To elucidate the relationship between DNA adduct formation and tumorigenesis, a number of experiments have been conducted to measure DNA adducts in target tissues from experimental animals during continuous exposure to carcinogens. With aflatoxins, aromatic amines, and polycyclic aromatic hydrocarbons, tumor induction appears to be associated with the major DNA adduct detected, whereas with N-nitrosamines the response is normally correlated with minor forms of DNA damage. During continuous carcinogen administration, steady-state adduct concentrations are generally obtained in the target tissues, and there is often a linear correlation between the carcinogen concentration and the steady-state DNA adduct level. Exceptions exist when the mechanism of activation changes or with the onset of significant toxicity. Steady-state DNA adduct levels are often linearly related to the tumorigenic response. Carcinogen-induced cell proliferation occurs when significant deviations from linearity are observed. Because DNA adducts detected in humans are chemically identical to those found in experimental animals, DNA adduct data in animals may contribute to our understanding of human cancer risk.
Highlights
Journal: JAMA Neurology (2019)

Pioglitazone Therapy in Patients With Stroke and Prediabetes 526Insulin resistance should be treated in patients with stroke to prevent recurrent events, but quantification of such resistance in recent trials has been complex.In a post hoc subset analysis of the Insulin Resistance Intervention After Stroke (IRIS) randomized clinical trial of 2885 patients with prediabetes as defined by hemoglobin A 1c level and/or fasting glucose level, 1456 patients were randomly assigned to receive pioglitazone and 1429 to placebo.Spence and coauthors found that there was a significant reduction of cardiovascular events and newonset diabetes in patients with good adherence (at least 80% of the protocol dose taken), suggesting that insulin resistance screening and insulin-sensitizing agents as needed should be introduced into standard treatment of patients with stroke and prediabetes.Editorial perspective is provided by Pantoni.
TennCare
Authors: John E. Gore
Journal: JAMA (1996)

<h3>To the Editor.</h3> —I wish to address several statements made by Dr Mirvis and colleagues in their recent article.<sup>1</sup>The authors state, "More than 40% of potential beneficiaries did not respond. The resulting confusion forced the state [of Tennessee] to initiate a second enrollment period in December 1993." This statement gives an incorrect picture in at least three respects. The fact that 60% of the potential beneficiaries did respond with a completed ballot selection is an unheard-of response rate for Medicaid populations. Under the Medicaid program, response rates to mail-outs were considered successful if they reached 20%. Although there was confusion, there was no second enrollment period. During 1994, the enrollment for TennCare was open all year, as originally planned. TennCare provided a 45-day allowance for individuals seeking to change managed care organizations (MCOs). This was instituted for those choosing an MCO based on the belief that their clinicians
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1957)

COMMITTEE ON MATERNAL WELFAREMassive EmbolismA thirty-six-year-old gravida 3 died suddenly the day after repeat cesarean section. The first pregnancy had been terminated by cesarean section after a short test of labor because of fetal distress associated with a borderline pelvis. The second baby had also been delivered by cesarean section.The current pregnancy was uncomplicated. Specifically, there were no varicose veins. The patient gained 11.3 kg. (25 pounds) and weighed 68 kg. (150 pounds) when she entered the hospital twelve days before the estimated date of confinement. The blood pressure was 126 systolic, 64 diastolic; the nonprotein nitrogen . . .
Transactions of the Fifteenth Annual Meeting of the American Laryngological Association,
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of infants destined to die unexpectedly during infancy: evaluation of predictive importance of prolonged apnoea and disorders of cardiac rhythm or conduction.
Journal: BMJ (1983)

Twenty four hour tape recordings of electrocardiogram and breathing movement were made prospectively in 6914 full term and 2337 preterm infants or infants of low birth weight during their first six weeks of life. These recordings included 40 obtained in 29 infants who subsequently suffered the sudden infant death syndrome and 13 obtained in 10 other infants who died suddenly and unexpectedly. None of the recordings obtained in the infants who suffered the sudden infant death syndrome showed prolonged apnoea (cessation of breathing movement for 20 seconds or more) or pre-excitation. One infant had multiple ventricular premature beats (38/hour). Compared with recordings obtained in 211 control infants who did not die none of the recordings obtained in the infants who suffered the syndrome showed abnormal prolongation of the QT interval.