tbuckley/cabot-search huggingface dataset:
THE WICKED HOUSE FLY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil
Authors: Tarub S. Mabud, Maria de Lourdes Delgado Alves, Albert I. Ko, Sanjay Basu, Katharine S. Walter, Ted Cohen, Barun Mathema, Caroline Colijn, Everton Lemos, Julio Croda, Jason R. Andrews
Journal: PLoS Medicine (2019)

[This corrects the article DOI: 10.1371/journal.pmed.1002737.].
In this issue
Authors: Peter Kirkpatrick, Alexandra Flemming, Charlotte Harrison, Sarah Crunkhorn, Monica Flight, Asher Mullard, Man Tse, Katie Kingwell, Mariam Faruqi, Lucie Wooton, Lewis Packwood, Susie Lanni, Susanne Harris, Vicky Summersby, Patrick Morgan, Kirsten Lee, Judith Shadwell, Simon Fenwick, Natalie Smith, Laura Corns, Ella Lines, Deborah Anthony, Tim Redding
Journal: Nature Reviews Drug Discovery (2011)
Intercapillary Glomerulosclerosis
Authors: Paul Kimmelstiel, William B. Porter
Journal: New England Journal of Medicine (1948)

Relation to Hypertension and ArteriolosclerosisA close relation between intercapillary glomerulosclerosis and arteriolosclerosis of the kidney has been obvious to all observers.4,6,7,8 The two lesions roughly parallel each other, but a sufficient number of exceptions exist to justify the statement that the relation is likely to be coincidental. Although arteriolosclerosis cannot be excluded as a contributing factor in bringing about intercapillary glomerulosclerosis, it cannot be regarded as the sole cause. In the age group in which most cases of intercapillary glomerulosclerosis occur, a large percentage of patients reveal marked arteriolosclerosis of kidneys with or without the glomerular lesions. Intercapillary glomerulosclerosis . . .
Triple Therapy Better for Advanced Melanoma
Journal: Cancer Discovery (2020)

Abstract Adding a PD-L1 inhibitor to a standard targeted therapy for patients with untreated BRAF V600 mutation–positive advanced melanoma led to significantly improved progression-free survival, according to findings presented at the American Association for Cancer Research Virtual Annual Meeting Part I: April 27–28, 2020. The results add to evidence that combining immune checkpoint blockade with MEK–BRAF inhibition produces more clinically meaningful survival benefits than either MEK–BRAF or immune checkpoint inhibition alone.
TUBERCULOUS OTITIS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response assessment in metastatic melanoma treated with ipilimumab and bevacizumab: CT tumor size and density as markers for response and outcome
Authors: Mizuki Nishino, Anita Giobbie-Hurder, Nikhil H Ramaiya, F Hodi
Journal: Journal for ImmunoTherapy of Cancer (2014)

<h3>Background</h3> Investigate the tumor diameter and density changes in advanced melanoma patients treated with ipilimumab plus bevacizumab, compare response rates based on different response criteria, and study association between these measures and survival. <h3>Methods</h3> Twenty-one advanced melanoma patients with 59 measurable lesions treated in a phase 1 trial of ipilimumab plus bevacizumab were retrospectively studied. Tumor diameter and density were measured on baseline and first follow-up CT. Responses were assigned using RECIST, MASS and Choi criteria. Diameter and density measures and responses by these criteria were studied for the association with survival. <h3>Results</h3> Twenty-three (39%) lesions and 7 (33%) patients met the Choi density criteria for response (≥15% density decrease) at the first follow-up. The response rates were 14% (3/21, 95% CI: 3-36%) by RECIST and MASS, and 52% (11/21, 95% CI: 30-74%) by Choi criteria, when both size and density criteria were used. Larger baseline tumor diameter was significantly associated with shorter progression-free survival (PFS) and overall survival (OS) (log-rank p = 0.001 and 0.003; respectively). Diameter or density changes, or responses by RECIST, MASS or Choi criteria at the first follow-up, were not associated with PFS or OS. <h3>Conclusion</h3> Tumor density decrease meeting Choi criteria was noted in one-third of advanced melanoma patients at the first follow-up scan during ipilimumab plus bevacizumab therapy. While larger baseline tumor diameter was strongly associated with shorter survival, changes of diameter or density, or responses by three criteria did not predict survival. The role of density changes in evaluating response during ipilimumab and bevacizumab therapy for advanced melanoma remains to be further established.
Rubella Vaccination
Authors: John F. Enders
Journal: New England Journal of Medicine (1970)

Historically, the adoption for general use of each new vaccine has brought to light a variety of problems. Rubella vaccine, licensed last year for general distribution, has proved to be no exception. Certain potential difficulties were recognized early in its development but were considered to be of minor importance. Others emerged only when vaccination began to be practiced on a large scale. The adoption in this country of a novel hypothesis governing the application of this product has introduced a source of complications not inherent in the use of earlier attenuated virus vaccines.According to this hypothesis, prevention of infection . . .
Classifying people living with hepatitis C virus using a population-level latent class analysis to inform optimal integration of health services
Authors: Emilia Clementi, Sofia Bartlett, Naveed Janjua, Stanley Wong, Amanda Yu, Dr. Margo Pearce, Mawuena Binka, Maria Alvarez, Dahn Jeong, James Wilton, Prince Adu, Younathan Abdia, Dr. Jason Wong, Mel Krajden, Jane Buxton, Michael Otterstatter, Zahid Butt, Geoff McKee
Journal: Journal of Hepatology (2020)
Paludrine
Authors: J. N. Dugdale
Journal: BMJ (1948)

Genetic variations in <i>CACNA1C</i>, which encodes the Ca<sub>v</sub>1.2 subunit of L-type calcium channels (LTCCs), are associated with multiple forms of neuropsychiatric disease that manifest high anxiety in patients. In parallel, mice harboring forebrain-specific conditional knockout of <i>cacna1c</i> (forebrain-Ca<sub>v</sub>1.2 cKO) display unusually high anxiety-like behavior. LTCCs in general, including the Ca<sub>v</sub>1.3 subunit, have been shown to mediate differentiation of neural precursor cells (NPCs). However, it has not previously been determined whether Ca<sub>v</sub>1.2 affects postnatal hippocampal neurogenesis <i>in vivo</i>. Here, we show that forebrain-Ca<sub>v</sub>1.2 cKO mice exhibit enhanced cell death of young hippocampal neurons, with no change in NPC proliferation, hippocampal size, dentate gyrus thickness, or corticosterone levels compared with wild-type littermates. These mice also exhibit deficits in brain levels of brain-derived neurotrophic factor (BDNF), and Cre recombinase-mediated knockdown of adult hippocampal Ca<sub>v</sub>1.2 recapitulates the deficit in young hippocampal neurons survival. Treatment of forebrain-Ca<sub>v</sub>1.2 cKO mice with the neuroprotective agent P7C3-A20 restored the net magnitude of postnatal hippocampal neurogenesis to wild-type levels without ameliorating their deficit in BDNF expression. The role of Ca<sub>v</sub>1.2 in young hippocampal neurons survival may provide new approaches for understanding and treating neuropsychiatric disease associated with aberrations in <i>CACNA1C</i>. Visual Abstract
Leave of Absence
Authors: K A Scannell
Journal: Annals of Internal Medicine (2000)

Personal Time4 January 2000Leave of AbsenceKate A. Scannell, MDKate A. Scannell, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-1-200001040-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When I discovered that I had cancer 1 hour and 40 minutes before leaving for Paris, I was transported into an eerie seam between thought and feeling. In this wordless void, I groped for understanding and emotion—the usual evidence of my existence. The shock of my disembodiment unmoored me from physical time, and I drifted chaotically through future, past, and present. When thoughts and feelings did stir, they seemed to belong to someone else, to some body that I had inhabited. It was as though I were watching them projected onto a screen from an archival recollection of my being.... Author, Article, and Disclosure InformationAuthors: Kate A. Scannell, MDCorresponding Author: Kate A. Scannell, MD, Kaiser Permanente, 280 West MacArthur Boulevard, Oakland, CA 94611. For reprint orders in quantities exceeding 100, please contact the Reprints Coordinator; phone, 215-351-2657; e-mail, reprints@mail.acponline.org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe time that remains: Self-identity and temporality in cancer and other life-threatening illnesses and in Messianic experienceTemporality and Illness: A Phenomenological Perspective 4 January 2000Volume 132, Issue 1 Page: 55-57 Keywords Biopsy Emotions Forecasting Hearing Memory Pathologists Shock Skull Surgery Uterus ePublished: 15 August 2000 Issue Published: 4 January 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Gastric Tuberculosis
Authors: R.C. Misra, S.K. Agarwal, P. Prakash, M.M. Saha, P.S. Gupta
Journal: Endoscopy (1982)

A 63-year-old female presented with upper epigastric pain. On endoscopy a giant gastric ulcer was observed on the lesser curvature of the stomach. Biopsies taken from the ulcer showed epitheloid cell granulomas with caseation, suggesting a diagnosis of granulomatous gastritis probably tubercular in origin. No AFB was seen in the biopsied material, the culture also failed to grow AFB. Radiograph of the chest was normal. On anti-tubercular treatment the patient showed remarkable recovery and the ulcer healed completely following 3 1/2 months of treatment.
American Society of Clinical Oncology Policy for Relationships With Companies: Background and Rationale
Journal: Journal of Clinical Oncology (2013)

The American Society of Clinical Oncology's (ASCO's) new conflict of interest policy reflects a commitment to transparency and independence in the development and presentation of scientific and educational content. ASCO supports thorough and accessible disclosure of financial relationships with companies at institutional and individual levels and calls for rigorous evaluation of content in light of the information disclosed. For abstracts and articles presenting original research, ASCO holds first, last, and corresponding authors to a clear standard of independence. In imposing restrictions, the new policy focuses on the role of these authors rather than of the principal investigator(s) as in the previous policy. ASCO remains actively engaged with the broader scientific community in seeking and implementing efficient, effective approaches to conflict of interest management.
Highlights from this issue
Authors: E. El-Omar, A. Gerbes, W. Grady
Journal: Gut (2011)

New insights into the factors that cause Barrett's oesophagusThe mechanisms responsible for the transformation of the normal oesophageal squamous epithelium into the metaplastic intestinal epithelium that characterises Barrett's oesophagus are poorly understood, but are essential to know in order to develop better ways for preventing Barrett's oesophagus.Prior work by the authors of this study and by others has shown that a transcription factor called CDX2 is one of the mechanisms involved in the formation of Barrett's oesophagus.Kazumori and colleagues now show that Kruppel-Like Factor 4 (KLF4), a key protein that regulates the differentiation of the epithelium of the gastrointestinal tract, is a second transcription factor strongly expressed in Barrett's epithelium that is induced by bile acids.Importantly, they have shown that KLF4 and CDX2 cooperate to induce each other's expression and that KLF4 induces the expression of the mucin protein MUC2, which is involved in intestinal metaplasia.Moreover, they also show that the inflammation related signalling pathway, NF-kB, is also involved in this process.This study advances our understanding of the transcriptional network related to KLF4 and CDX2 that affects the development of Barrett's oesophagus.KLF4 and CDX2 are possible molecular targets for the prevention of Barrett's oesophagus, and therapies directed at these proteins may yield a much-needed medical treatment for Barrett's oesophagus (see page 608).
Mammography-Reply
Authors: James F. Newsome
Journal: JAMA (1986)

<h3>In Reply.—</h3> We appreciate the comments of Drs Hall and Holleb in reference to our COMMENTARY on mammography. They underscore our belief that the emphasis on diagnostic mammography has resulted in the fact that as a screening tool, as Dr Hall states, it has been "undersold." Our primary concern was with symptomatic women. Our comments are directed primarily to those physicians who assume the ultimate responsibility for establishing the presence of breast cancer at its most favorable stage. In our zeal to promote mammography, we should not lose sight of the fact that it is a procedure requiring considerable attention to technique with experienced and careful interpretation. Even under these circumstances there is a significant false-negative rate. The range of false-negatives we cited represents extremes but serves to indicate that some breasts, fortunately a minority, do not lend themselves to good radiographic interpretation. We suspect, despite the improvement in the
Abstract 1835: Nqo1 ablation inhibits activation of the PI3K/Akt and MAPK/ERK pathways and blocks metabolic adaptation in hepatocellular carcinoma
Authors: Manali Dimri, Ashley Humphries, Archana Laknaur, Sawsan Elattar, Ashok Sharma, Ravindra Kolhe, Ande Satyanarayana
Journal: Cancer Research (2019)

Abstract According to the World Health Organization, hepatocellular carcinoma (HCC) is the 2nd leading cause of cancer related deaths worldwide. HCC is highly resistant to conventional chemotherapies; therefore, identification of specific molecular targets for the development of targeted therapies is indispensable. Cancer cells undergo metabolic adaptation to sustain uncontrolled proliferation and depends on the high rate of glycolysis and glutaminolysis. Hence, identifying and targeting proteins that assist cancer cells in metabolic reprogramming is an effective strategy to block their proliferation. We detected a strong upregulation of NAD(P)H Quinone Dehydrogenase 1 (Nqo1), a cytosolic flavoprotein, in vivo in mouse and human liver tumors as well as in liver cancer cell lines in vitro. Knockdown of Nqo1 in liver cancer cells by shRNA caused a significant downregulation of both glycolytic and glutaminolysis genes, impaired cell proliferation, colony formation and in vivo xenograft tumor growth. Nqo1-/- mice with HCC displayed significant reduction in tumor number, size and growth. In Nqo1+/+ mice, histological analysis of liver tumors revealed large tumor cells with hyperchromatic nuclei in a compact growth pattern, whereas Nqo1-/- livers appeared normal. Hyper-activated PI3K/Akt and MAPK/ERK signaling pathways play central role in cancer cell metabolic adaptation since their downstream effectors such as Akt and c-Myc control most of the glycolytic and glutaminolysis genes. Interestingly, at the molecular level, Nqo1 knockdown caused strong upregulation of the tumor suppressor PTEN, and enhanced activation of the serine/threonine phosphatase PP2A, leading to impaired activation of the PI3K/Akt and MAPK/ERK/c-Myc pathways. Our findings indicate that, by targeting PP2A and PTEN, Nqo1 enhances the expression and/or activity of PDK1, Akt, ERK1/2 and c-Myc and promotes cancer cell metabolic reprogramming and hence may function as a key therapeutic target for HCC inhibition. Citation Format: Manali Dimri, Ashley Humphries, Archana Laknaur, Sawsan Elattar, Ashok Sharma, Ravindra Kolhe, Ande Satyanarayana. Nqo1 ablation inhibits activation of the PI3K/Akt and MAPK/ERK pathways and blocks metabolic adaptation in hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1835.
Software
Authors: Robert Feinstein
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SIMPLE GOITER—A PREVENTABLE DISEASE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
5. Hodgkin's Disease
Authors: A Sarris, L Medeiros, K Kliche, G Nadali, G Rassidakis, S Viviani, V Bonfante, T Vassilakopoulos, R Giardini, M Chilosi, C Kittas, T Witzig, M Gianni, G Bonadonna, G Pizzolo, G Pangalis, F Cabanillas
Journal: Annals of Oncology (2002)
Lung Cancer
Authors: William C. Alford
Journal: JAMA (1986)

This first volume of collected topics in general thoracic surgery is reminiscent of the<i>Clinics of North America</i>series. The editors state a wish to bridge the gap between textbook and journal information on noncardiac thoracic surgery topics and have a way to update the information periodically. A board of editors from North America, Europe, and elsewhere was selected "to make certain that important advances can be drawn to the attention of thoracic surgeons around the world as quickly as possible." Lung cancer is the subject of the first volume, and ten additional subjects are noted for future publication. The rate of publishing is not mentioned. Since not all aspects of lung cancer are rapidly changing and controversial, some of the 27 chapters contain little, if any, new material. Histogenesis and staging are important aspects of lung cancer, but new material is rare. The chapters on certain aspects of surgical