tbuckley/cabot-search huggingface dataset:
A phase II study of second-line bendamustine in relapsed or refractory small cell lung cancer (SCLC).
Authors: N. K. Venepalli, A. S. Hutchison, D. P. Carbone, D. H. Johnson, V. L. Keedy, W. Pao, A. Sandler, L. Horn
Journal: Journal of Clinical Oncology (2011)

e17505 Background: Bendamustine is an alkylating agent with a nitrogen mustard group and purine-like benzimidazole group. Bendamustine in combination with carboplatin has shown efficacy as first line therapy in extensive stage SCLC with RR 73%, TTP 5.2 months and OS 8.3 months [Köster W et al. J Tho Onc. 2007;2(4):312-6]. This study aims to examine the safety and efficacy of single agent bendamustine as 2nd or 3rd line therapy in patients (pts) with SCLC. Methods: This is an open-label, multicenter phase II trial. Eligible pts had previously treated SCLC, up to 2 prior regimens, PS 0-2, evaluable/measurable disease, adequate marrow, renal and hepatic function. Pts with stable treated brain metastases were allowed. Pts were treated with bendamustine (120mg/m2 IV days 1 and 2 every 3 weeks) up to 6 cycles and evaluated every 2 cycles. Primary endpoint was TTP; secondary endpoints include RR, PFS, OS, and toxicity. Results: 28 pts have enrolled to date (target accrual 60); 19 pts were evaluable for response; there were 7 PR, 7 SD and 5 PD. Median TTP was 2.5 months. At the time of analysis, 12 pts were alive. Median number of cycles given was 2. 5 pts required dose reductions due to AEs. Grade 3/4 AEs included neutropenia 14.3%, fatigue 10.7%, anemia and diarrhea 7.1% and less commonly, thrombocytopenia, nausea, infection, hyponatremia, pulmonary at 3.6%. Conclusions: These preliminary data indicate that single agent bendamustine appears to be well tolerated and effective in the second or third line setting for patients with SCLC. Accrual is ongoing.
Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics
Authors: M. Nikanjam, P.R. Cohen, S. Kato, J.K. Sicklick, R. Kurzrock
Journal: Annals of Oncology (2019)

Ann Oncol 2018; 29(11): 2192–2199 (doi: 10.1093/annonc/mdy412) Figure 1B has been corrected to display as follows: The Publisher apologizes for the error. Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeuticsAnnals of OncologyVol. 29Issue 11PreviewMetastatic basal cell carcinoma is an ultra-rare manifestation of a common disease, appearing in 0.0028%–0.5% of basal cell carcinomas. Initial therapeutic efforts focused on cytotoxic chemotherapy administration. However, it is now known that the Hedgehog signaling pathway is crucial for basal cell proliferation and Hedgehog pathway mutations may lead to tumorigenesis; thus, small-molecule inhibitors of alterations in the components of this pathway, including smoothened (SMO) and GLI, have been the focus of recent therapeutic developments. Full-Text PDF Open Archive
Reply to Dr Stoddard
Journal: Neuro-Oncology (2019)

We thank Dr Stoddard and his team for providing an important historical discovery that gave confidence to the creation of Toca 511 and highlights our timely response (October 2016 1 ) to his eLetter in Science Translational Medicine in 2016.We also note that it is not typical, in our experience, to describe the molecular details of an agent in a clinically oriented manuscript, but rather to provide the references that would allow any interested party to find that information.One recent example is the manuscript describing the phase II trial of tisagenlecleucel (anti-CD19 CAR T cells) in pediatric and young adult patients with CD19+ relapsed or refractory B-cell acute lymphoblastic leukemia. 2We assume it is not due to lack of respect for the molecular scientists but rather the practicalities that it is not useful for the typical clinical reader to re-describe work that has been previously published in detail.Dr Stoddard and colleagues' achievements were referenced directly 3 in a recent molecularly oriented publication.No disrespect to these investigators was intended by not highlighting their contribution to the basic science research of the molecular compositions.Many factors, both historical and newly discovered, went into the development of Toca 511, which has been appropriately described in detail. 4,5 Sincerely, Timothy F.
COMPLEXION AND ABILITY.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection
Authors: K Sugimoto
Journal: Hepatology (2003)

Hepatitis C virus (HCV) has a high propensity for persistence. To better define the immunologic determinants of HCV clearance and persistence, we examined the circulating HCV-specific T-cell frequency, repertoire, and cytokine phenotype ex vivo in 24 HCV seropositive subjects (12 chronic, 12 recovered), using 361 overlapping peptides in 36 antigenic pools that span the entire HCV core, NS3-NS5. Consistent with T-cell-mediated control of HCV, the overall HCV-specific type-1 T-cell response was significantly greater in average frequency (0.24% vs. 0.04% circulating lymphocytes, P = .001) and scope (14/36 vs. 4/36 pools, P = .002) among the recovered than the chronic subjects, and the T-cell response correlated inversely with HCV titer among the chronic subjects (R = −0.51, P = .049). Although highly antigenic regions were identified throughout the HCV genome, there was no apparent difference in the overall HCV-specific T-cell repertoire or type-1/type-2 cytokine profile relative to outcome. Notably, HCV persistence was associated with a reversible CD4-mediated suppression of HCV-specific CD8 T cells and with higher frequency of CD4+CD25+ regulatory T cells (7.3% chronic vs. 2.5% recovered, P = .002) that could directly suppress HCV-specific type-1 CD8 T cells ex vivo. In conclusion, we found that HCV persistence is associated with a global quantitative and functional suppression of HCV-specific T cells but not differential antigenic hierarchy or cytokine phenotype relative to HCV clearance. The high frequency of CD4+CD25+ regulatory T cells and their suppression of HCV-specific CD8 T cells ex vivo suggests a novel role for regulatory T cells in HCV persistence. (Hepatology 2003;38:1437-1448.)
PLASMA VOLUME EXPANDERS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Fifth Plague of Egypt
Authors: M. G. Jacoby
Journal: JAMA (1983)

<h3>To the Editor.—</h3> I would like to take exception to both editorials in the Jan 14, 1983, issue ofThe Journal. It is clear that boxing injuries can result in irreversible brain damage, and I personally abhor the practice. However, this does not justify the prohibition or regulation of this dangerous practice. It seems that physicians who desire to restrict boxing wish to exert dictatorial control over the life-styles of persons who choose to box. The fact is that persons who choose to box are autonomous, just like the rest of us, and are capable of judging for themselves how much risk they are willing to take. We physicians may disagree with their values, but that does not give us the right to impose our values by force. If a boxer values money more than the risk of injury, then that person has the right to act on his own values, even if
Complications associated with ambulatory surgery
Authors: H. E. Natof
Journal: JAMA (1980)

The interest in ambulatory surgery has grown substantially during the past ten years. To evaluate the medical aspects of ambulatory care objectively, there must be accurate, reliable, and pertinent complication data. A prospective study of 13,433 patients at a freestanding ambulatory surgical center was performed. Ninety-nine and eight-tenths percent of the patients were followed up through the first two postoperative weeks. One hundred six medical, surgical, or anesthetic complications were identified in the patient population. No deaths occurred in the center, and there was no instance of cardiovascular collapse. Sixteen patients were transferred to a general hospital. Surgery and anesthesia performed in either the inpatient or outpatient setting may be associated with serious complications. Many surgical procedures can be performed as safely in the outpatient setting as in the hospital inpatient setting. (<i>JAMA</i>244:1116-1118, 1980)
Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 1. Morphology and inhibition of fibrogenesis by dipyridamole
Authors: I Wanless
Journal: Hepatology (1996)

This study documents the hepatic morphology and the ultrastructure of a model of hepatic fibrosis in rabbits. Rabbits were given a cholesterol- supplemented diet (1%), a stilbestrol diet (10 mg subcutaneously twice a week), or both treatments simultaneously for 7 weeks. Rabbits given the combined treatment developed sinusoidal and portal fibrosis with only a mild disturbance of acinar vascular relationships. Ultrastructurally, there was marked widening of the spaces of Disse by collagen fibers, basement membrane material adjacent to endothelial cells and hepatocytes, blunted hepatocellular microvilli, activated stellate cells, lipid droplets in endothelial cells and hepatocytes, and degranulated platelets in sinusoids. The hepatic hydroxyproline content was markedly increased (12.0 ± 5.2 vs. 4.8 ± 1.5 mmol/g of liver dry weight; P < .001). Plasma bile acids were markedly increased (222 ± 180 vs. 12 ± 5 in controls; P < .001). Dipyridamole (25 mg every 12 hours) that was given in addition to cholesterol and stilbestrol decreased the hepatic collagen content (-49% and -48%, in two experiments; P < .05 in both) and splenomegaly. This model provides a reliable method for the production of extensive sinusoidal fibrosis with capillarization of sinusoids. Hepatocellular degeneration is only mild to moderate, and fibrosis occurs slowly without the sudden pathological changes that occur with other models of hepatic fibrosis, such as with the administration of CCl4 or galactosamine. The mechanism of injury may involve the accumulation of bile salts or the generation of free radicals from cholesterol oxidation products. The possibility that the sinusoidal release of platelet-derived factors may have a role in the activation of stellate cells (lipocytes) is supported by the suppression of fibrogenesis by dipyridamole.
Hereditary spherocytosis, thrombocytosis, and chronic pulmonary emboli: A case report and review of the literature
Authors: Julieta E. Hayag‐Barin, Roy E. Smith, Frederick C. Tucker,
Journal: American Journal of Hematology (1998)

Thrombocytosis in post-splenectomy patients with hereditary spherocytosis (HS) is usually not attended by an increased risk of thrombosis. Review of the literature revealed HS in association with pulmonary thrombosis, portal vein thrombosis, and cerebral infarction in two brothers, TTP in an asplenic patient and a patient with corpora cavernosum thrombosis causing segmental priapism. We report a case of a 30-year-old white male with HS who presented with hemoptysis 29 years after splenectomy. Work-up revealed a hypercoagulable state with thrombocytosis and recurrent pulmonary emboli resulting in severe pulmonary hypertension, cor pulmonale, atrial flutter, and syncope. Am. J. Hematol. 57:82–84, 1998. © 1998 Wiley-Liss, Inc.
Author's Reply
Authors: Margaret Gatz
Journal: PLoS Medicine (2005)

Gatz's statement, "At least half of the explanation for individual differences in susceptibility to Alzheimer disease is genetic" [1], is, in my opinion, incorrect.As the one who led the team debating Ashford and Mortimer, whose 2002 article [2] supports this statement, at the 2001 conference on Alzheimer disease (AD) in Cincinnati ("Challenging Views of Alzheimer's Disease") [3], I think that the evidence that dietary and lifestyle factors explain the majority of the individual risk for AD in the US is very strong.My original paper in 1997 [4] found that total dietary fat and energy intake were the most important dietary risk factors, while fi sh and cereal intake were the most important risk reduction factors.These fi ndings have been generally confi rmed by Drs.Luchsinger and Morris and others.The reason I did my study was that the Honolulu Heart Study reported that Japanese American men in Hawaii had 2.5 times the risk of AD of native Japanese.African-Americans have about four times the risk of AD of native Nigerians.If genetics were the primary risk factor, those living in the US would have a risk of developing AD very similar to that of individuals living in their ancestral home.The reason this is not the case is that the American diet provides too much food, which is a particular problem for those genetically predisposed to AD.
Standard Methods for the Examination of Water and Sewage.
Journal: JAMA (1920)

This edition contains few important changes. No changes whatever have been made in the chemical procedures. In the preparation of culture mediums, American peptones have been made standard, and the concentration of carbohydrates in broths has been reduced from 1 to 0.5 per cent. The most important addition to the methods is the introduction of phenol red for adjusting the reaction of mediums. This should rapidly replace titration with phenolphthalein.
Abstract 2874: A γ-tocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth
Authors: Gang Lu, Hang Xiao, GuangXun Li, Sonia C. Picinich, Yu-Kuo Chen, Anna Liu, Mao-Jung Li, Shea Loy, Chung S. Yang
Journal: Cancer Research (2010)

Abstract The present study investigated the effects of a preparation of a γ-tocopherol (γ-T)-rich mixture of tocopherols (γ-TmT) and its combination with EGCG on chemically induced lung tumorigenesis in female A/J mice and the growth of H1299 human lung cancer cell xenograft tumors. In the A/J mouse model, the lung tumors were induced by either 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; i.p. injections with 100 and 75 mg/kg on Week 1 and 2, respectively) or NNK plus benzo[a]pyrene (B[a]P) (8 weekly gavages of 2 μmol each from Week 1 to 8). The NNK plus B[a]P treatment induced 21 tumors per lung on Week 19; dietary 0.3% γ-TmT treatment during the entire experimental period significantly lowered tumor multiplicity, tumor volume and tumor burden (by 30%, 51% and 60%, respectively; P&amp;lt;0.05). For three groups of mice treated with NNK alone, the γ-TmT diet was given during the initiation stage (Week 0 to 3), the post-initiation stage (Week 3 to 19), or the entire experimental period, and tumor multiplicity was reduced by 17.8%, 19.7%, or 29.3%, respectively (P&amp;lt;0.05). γ-TmT treatment during the tumor initiation stage or throughout the entire period of the experiment also significantly reduced tumor burden (by 36% or 43%, respectively). In the xenograft tumor model of human lung cancer H1299 cells in NCr-nu/nu mice, 0.3% dietary γ-TmT treatment significantly reduced tumor volume and tumor weight by 56% and 47%, respectively (P&amp;lt;0.05). In both the carcinogenesis and tumor growth models, the inhibitory action of γ-TmT was associated with enhanced apoptosis and lowered levels of 8-hydroxydeoxyguanine, γ-H2AX and nitrotyrosine in the tumors of the γ-TmT-treated mice. These results demonstrate the inhibitory effect of γ-TmT against lung tumorigenesis and the growth of xenograft tumors of human lung cancer cells. The inhibitory activity may be due mainly to the actions of δ-T and γ-T. We further studied the tumor inhibitory effects of a combination of γ-TmT and EGCG in the above mentioned NNK-induced lung tumorigenesis model. The treatment with γ-TmT (0.3%), EGCG (0.4%), and the combination at half doses (0.15% γ-TmT plus 0.2% EGCG) all significantly reduced the tumor multiplicity in the NNK-induced model. In this experiment, we observed by immunohistochemistry that dietary γ-TmT treatment increased the glutathione peroxidase and superoxide dismutase levels, but EGCG treatment had no effect on these two enzymes. The levels of catalase, heme oxigenase-1 and Nrf2 were not changed by either agent (Supported by NIH grants CA122474 and CA 133021). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2874.
Successful treatment of severe refractory idiopathic thrombocytopenic purpura with liposomal doxorubicin
Authors: Thomas M. Cosgriff, Marcus L. Black, William Stein
Journal: American Journal of Hematology (1998)

Idiopathic thrombocytopenic purpura (ITP) is refractory to initial treatment (steroids and splenectomy) in 25 to 30% of patients.These patients have a significant risk of fatal hemorrhage.Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded to treatment with liposomal doxorubicin with a return of platelet counts to normal.The drug is easily administered and was well tolerated.Use of this drug in refractory ITP merits further study.Am.
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Authors: Sarah Cuddy, Jerry Gurwitz
Journal: JAMA Cardiology (2020)

Tao Guo, MD; Yongzhen Fan, MD; Ming Chen, MD; Xiaoyan Wu, MD; Lin Zhang, MD; Tao He, MD; Hairong Wang, MD; Jing Wan, MD; Xinghuan Wang, MD; Zhibing Lu, MD
Sporotrichosis presenting as facial cellulitis
Authors: M. C. Pepper
Journal: JAMA (1980)

SPOROTRICHOSIS is an uncommon skin infection frequently involving the lymphatic system and is caused by the fungus<i>Sporothrix schenckii</i>. This organism is ubiquitous, being found in soil and on vegetation.<sup>1</sup>In the Midwest it is an occupational hazard for farmers and horticultural workers. The incidence of sporotrichosis in urban communities is much rarer, and consequently the diagnosis may be delayed.<sup>2</sup>For infection to occur, the organism had to be introduced into the dermis by traumatic implantation. The primary site is most often on an extremity. A rare primary pulmonary form has been reported occurring secondary to inhalation of spores.<sup>3</sup>Subclinical infection may occur in endemic areas. <h3>Report of a Case</h3> A 23-year-old man in good health was initially seen with a small soft-tissue facial infection. On examination a 1-cm, firm, slightly tender lesion was observed. He was afebrile, and no other abnormality was detected. Screening tests for systemic
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1961)

TREASURER'S OFFICEThis year the Committee on Finance has voted a refund of $6,000 to the district societies from the surplus in the General Fund at the end of 1960.Members are reminded that the percentage of this sum that is allocated to their own district is determined by the number of dues from that district paid by March 1, 1961. Members who have not paid their dues by this date are automatically removed from the mailing list of the Journal until such dues are paid.Eliot Hubbard, M.D. Treasurer COMMITTEE ON MATERNAL WELFARE*Panhypopituitarism Resulting from Septic ShockA . . .
Diabetes Mellitus—A Call for Papers
Authors: Catherine D. DeAngelis, David S. Cooper, Phil B. Fontanarosa
Journal: JAMA (2008)

For the second time this decade, JAMA will publish a theme issue devoted to the topic of diabetes mellitus. While some progress has been made in understanding and managing diabetes since the May 15, 2002, theme issue,1 the epidemic continues, as does JAMA's strong interest in this problem.
THE PASSING OF PRIMITIVE MAN.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal