tbuckley/cabot-search huggingface dataset:
EPN-31MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA
Authors: Kristian W. Pajtler, Tong Lin, Martin Sill, Chandanamali Punchihewa, Vijay Ramaswamy, Robert J. Ogg, Noah D. Sabin, Ji Wen, David T. W. Jones, Hendrik Witt, Arzu Onar-Thomas, Ruth G. Tatevossian, Michael D. Taylor, Stefan M. Pfister, Thomas E. Merchant, Marcel Kool, Andrey Korshunov, David W. Ellison
Journal: Neuro-Oncology (2016)
Medical News
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parallel 23: Fatty Liver Disease: Clinical and Therapeutic I
Authors: Richard Pencek, Tracy Mayne, Marco Carbone, George Mells, Jennifer Kramer, Peter Richardson, Danielle Liffmann, Hashem El-Serag, David Rein
Journal: Hepatology (2015)

the UK-PBC algorithm predicts a significant decrease in risk for liver transplant and liver-related death in patients treated with OCA+UDCA relative to placebo+UDCA.OCA has the potential to be an important new treatment option for PBC patients unable to achieve adequate response with UDCA.
Pontine Glioma
Authors: Thomas H. Milhorat
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The recent communication by Rosen et al (230:1149, 1974), which reported the "temporary but gratifying response" obtained in a child with a pontine glioma treated by high doses of intravenously administered methotrexate followed by leucovorin calcium rescue, points out the confusion that still surrounds this common childhood tumor. It is noteworthy that the paper fails to provide autopsy data—a prerequisite for any critical evaluation of the study, be it said—nor does it describe the histopathology of the tumor in question. Such omissions are unfortunate and can only be ascribed to the widely held but erroneous view that pontine gliomas constitute a uniform clinicopathologic entity. It is important to emphasize that gliomas of the brain stem, like their counterparts in the cerebral hemispheres, show a wide variation in both tissue morphology and biological behavior. This point is well substantiated in the literature<sup>1</sup>and is supported by a wide
Pedestrian accidents.
Journal: BMJ (1979)

A 6-year-old girl was knocked down by a car while trying to cross a busy road on her way to school.When she was recovering from her serious injuries the paediatrician asked why she had not crossed by the underpass."I didn't know how to use it," the child replied."But I did tell her to use it" was the mother's reaction. ChildrenThis case illustrates one of the many limitations of road safety training: young children cannot easily apply what they are told, even if they have it by heart like the Green Cross Code.
699 SUCCESSFUL ISOLATION, CULTURING AND DIFFERENTIATION IN VITRO AND IN VIVO OF MULTIPOTENT STEM CELLS (MPS) FROM HUMAN FETAL BILIARY TREE
Authors: R. Semeraro, A. Torrice, C. Napoli, V. Cardinale, G. Carpino, R. Gentile, M. Gatto, U. Di Tondo, R. Brunelli, M.M. Anceschi, C. Napoletano, M. Nuti, E. Gaudio, D. Alvaro
Journal: Journal of Hepatology (2011)
SIGNIFICANCE OF THROMBOANGIITIS OBLITERANS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Mystic
Authors: Stanley S. Schor
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Apparent cure of Letterer-Siwe disease. Seventeen-year survival of identical twins with nonlipoid reticuloendotheliosis
Authors: H. R. Bierman
Journal: JAMA (1966)

AS MEDICINE advances, our concepts of disease entities also must change as experience dictates. Letterer-Siwe disease is a malignant histiocytosis of infants which is generally considered neither hereditary nor infectious.<sup>1,2</sup> The disease today is characterized by an acute onset with hepatosplenomegaly, generalized lymphadenopathy, progressive anemia, neutropenia, lymphocytosis, and often hemorrhagic phenomena. Multiple focal, osteolytic lesions of the skull, vertebrae, pelvis, and ribs are present. Histopathology is characterized by nonlipoid hyperplasia of the reticuloendothelial system. The disease in the infant is usually rapidly fatal within a few months. <h3>Report of Cases</h3><h3>History.—</h3> In January 1949, 8-month-old male twins were seen with a presumptive diagnosis of acute lymphatic leukemia, which subsequently was proved by biopsy to be nonlipoid reticuloendotheliosis (Letterer-Siwe disease)<sup>3</sup>(Figure). Multiple antibiotic therapy to the point of stool sterilization led to dramatic improvement of twin A. Antibiotics were then prescribed for twin B, who promptly showed the same
Child molestation and pedophilia. An overview for the physician
Authors: A K Fuller
Journal: JAMA (1989)

Child sexual abuse is a serious, pervasive problem with clinical, social, moral, and legal implications. Between 100,000 and 500,000 children in the United States are thought to be sexually molested annually. Physicians in all specialties may detect sexual exploitation of youngsters and are mandated to report such cases. Failure to diagnose child molestation and pedophilia and to treat their cause can have serious, long-lasting consequences for innocent victims and continued distress for the perpetrator and for the professional who missed the diagnosis. A single child molester may commit hundreds of sexual acts on hundreds of children. The etiology of paraphilic syndromes is multifactorial. There are substantial differences among sexual abusers of children in their personalities and psychopathologies. Although available interventions are symptomatically palliative rather than curative, many pedophiles can benefit from appropriate treatment. Primary prevention may be the key to reducing the frequency of child sexual abuse.
PHYSIOMEDICALISM
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Boxing
Authors: Louis C. Arp
Journal: JAMA (1983)

<h3>To the Editor.—</h3> I was entirely in agreement with Dr Lundberg until I noticed in the last paragraph the sentence: "Boxing seems to me to be less sport than is cockfighting." Those of us who know and appreciate the sport of cockfighting see nothing obscene, uncivilized, or bloodthirsty in cockfighting and resent any comparison being made with boxing.
Phosphatidylinositol 4-kinases and the role of polyphosphoinositides in cellular regulation
Authors: L. J. Pike
Journal: Endocrine Reviews (1992)

PHOSPHOINOSITIDES play a central role in the transduction of signals for a variety of hormone and growth factor receptors. Multiple derivatives of phosphatidylinositol are present within the cell including phosphatidylinositol 4,5-bisphosphate, the phosphorylated derivative that is hydrolyzed by phospholipase C to produce the two intracellular second messengers, diacylglycerol and inositol 1,4,5-trisphosphate. The synthesis, degradation, and subsequent resynthesis of the phosphoinositides form a metabolic cycle known as the phosphoinositide cycle. The phosphoinositide cycle begins with the phosphorylation of phosphatidylinositol to form phosphatidylinositol 4-phosphate, a reaction catalyzed by phosphatidylinositol 4-kinase. Phosphatidylinositol kinase activity has been reported to be present in a variety of cellular membranes, and multiple isozymes of phosphatidylinositol 4-kinase are present within the cell, suggesting that the product of this reaction may have more than one biological function. The activity of phosphatidylinositol 4-kinase is regulated by growth factors, further underscoring the importance of this enzyme in cellular regulation. Recent data suggest that in addition to serving as substrates for phospholipase C, the polyphosphoinositides may themselves function as intracellular mediators of hormone action. For example, polyphosphoinositides have marked effects on the activity of certain actin binding proteins that may allow these lipids to participate in the regulation of actin polymerization. This review focuses on the properties of the phosphatidylinositol 4-kinases and the potential role of polyphosphoinositides in the regulation of cellular processes.
Venovenous bypass with a membrane lung to support bilateral lung lavage
Authors: W. M. Zapol
Journal: JAMA (1984)

Partial venovenous cardiopulmonary bypass with a membrane oxygenator was used to exchange respiratory gases during and after bilateral lung lavage in a patient with severe hypoxemia caused by pulmonary alveolar proteinosis. The patient was unable to tolerate an attempt at lung lavage without bypass. Therefore, extracorporeal perfusion safely supported the patient's respiration for 32 hours, buying time to lavage each lung separately and to enable sufficient recovery of transpulmonary gas exchanging capacity. (<i>JAMA</i>1984;251:3269-3271)
Comparative Pharmacokinetics and Subacute Toxicity of Di(2-Ethylhexyl) Phthalate (DEHP) in Rats and Marmosets: Extrapolation of Effects in Rodents to Man
Authors: Christopher Rhodes, Terry C. Orton, Iona S. Pratt, Peter L. Batten, Harold Bratt, Steven J. Jackson, Clifford R. Elcombe
Journal: Environmental Health Perspectives (1986)

Certain phthalate esters and hypolipidemic agents are known to induce morphological and biochemical changes in the liver of rodents, which have been associated with an increased incidence of hepatocellular tumors in these species.There is evidence that hypolipidemic agents do not induce these effects in either subhuman primates or man.The oral and intraperitoneal administration of di(2-ethylhexyl) phthalate (DEHP) to the marmoset monkey at doses up to 5 mmole DEHP/kg body weight/day for 14 days did not induce morphological or biochemical changes in the liver or testis comparable with those obtained in rats given the same amount of DEHP.In the marmoset, the excretion profile of [14C]-DEHP following oral, IP, and IV administration and the lower tissue levels of radioactivity demonstrated a considerably reduced absorption in this species compared to the rat.The urinary metabolite pattern in the marmoset was in many respects qualitatively similar to but quan- titatively different from that in the rat; the marmoset excreted principally conjugated metabolites derived from w -1 oxidation.The pharmacokinetic differences between these two species indicate that the tissues of the marmoset are exposed to a level of DEHP metabolites equivalent to the complete absorption of a dose of Ca. 0.1 to 0.25 mmole DEHP/kg body weight/day without significant toxicological effects.These exposure levels are at least 100-fold greater than the worst estimates of incidental human exposure (ca. 0.0015 mmole/ kg/day).They are comparable with the human therapeutic dose of many hypolipidemic drugs (ca. 0.15 mmole/ kg/day), a dose at which it is claimed that there is an absence of morphological or biochemical changes to human or subhuman primate liver.The evidence suggests that in some nonrodent species the hepatocellular and testicular response to DEHP is considerably less than that in rodents and is dose-dependent.
Drugs for Depression
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
一种治疗严重荨麻疹的新方法
Journal: British Journal of Dermatology (2020)

在我们生活中的某个时刻，多达四分之一的人遭受瘙痒性肿块（荨麻疹）的侵袭。幸运的是，这些侵袭通常是短暂的。然而，对于一些人来说，荨麻疹可能是持久的和/或严重的。这种致残的病症被称为慢性自发性荨麻疹（CSU）。顾名思义，这些侵袭不能归因于特定的过敏或身体接触。
THE DIAGNOSTIC VALUE OF AGGLUTINATION IN MIXED INFECTIONS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Herpesvirus latency
Authors: Jeffrey I. Cohen
Journal: Journal of Clinical Investigation (2020)

Herpesviruses infect virtually all humans and establish lifelong latency and reactivate to infect other humans. Latency requires multiple functions: maintaining the herpesvirus genome in the nuclei of cells; partitioning the viral genome to daughter cells in dividing cells; avoiding recognition by the immune system by limiting protein expression; producing noncoding viral RNAs (including microRNAs) to suppress lytic gene expression or regulate cellular protein expression that could otherwise eliminate virus-infected cells; modulating the epigenetic state of the viral genome to regulate viral gene expression; and reactivating to infect other hosts. Licensed antivirals inhibit virus replication, but do not affect latency. Understanding of the mechanisms of latency is leading to novel approaches to destroy latently infected cells or inhibit reactivation from latency.
Toxicity of Chloroprene, 1,3-Dichlorobutene-2, and 1,4-Dichlorobutene-2
Authors: J. J. Clary
Journal: Environmental Health Perspectives (1977)

A review of the toxicity of 1,3-dichlorobutene-2 (1,3-DCB), 1,4-dichlorobutene-2 (1,4-dcb), and 2-chlorobutadiene, 1,3 (beta-chloroprene) was undertaken with an emphasis on assessing the hazards of these materials in the industrial situation. 1,3-DCB is a by-product of beta-chloroprene from the acetylene route, with 1,4-DCB is an intermediate in the production of beta-chloroprene from the butadiene route, the production route used in the U.S. Presented in the review is a summary of the acute toxicity including mutagen testing, skin, eye, and inhalation testing of these compounds. In addition, subacute inhalation testing, embryotoxicity, teratogenicity, and carcinogenicity are also reviewed where the information is available.
A new approach to breast cancer. Breast uptake of 99mTc-HEDSPA
Authors: M. E. Siegel
Journal: JAMA (1974)

Thirty-three patients with carcinoma of the breast had routine bone scans performed with Tc-labeled 1-hydroxy-ethylidene-1,1-disodium phosphonate. Twenty-four of these patients had increased radioactivity in the clinically normal breast in addition to the abnormal breast, if present. Only 2 of the 17 patients studied who had no carcinoma of the breast had bilateral uptake. Both of these had bilateral fibrocystic disease. No patient with two normal breasts had increased uptake in either breast. Of those patients who had uptake in the clinically normal breast, 93% (24/26) had carcinoma. (<i>JAMA</i>229:1769-1771, 1974)
An abbreviated 2-step dobutamine provacation to aid in guidance of alcohol septal ablation for hypertrophic obstructive cardiomyopathy John B. Patterson, Kevin M. Rankin, Sanjay K. Gandhi, Dalane W. Kitzman, Gregory A. Braden. Wake Forest University School of Medicine, Winston-Salem, NC
Journal: Journal of the American College of Cardiology (2001)
Symposium on the plasma membrane, New York Heart Association, Inc., New York City, December 8-9, 1961.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal