tbuckley/cabot-search huggingface dataset:
Air pollutants might aggravate athletes' asthma, allergies
Authors: L. M. Prescott
Journal: JAMA (1984)

Olympic athletes with hyperactive airways could be at a disadvantage when participating in the Los Angeles games this summer because of the presence of high levels of pollutants in the atmosphere, in the opinion of one of the Australian team physicians. Considering that the major pollutants, ozone and sulfur dioxide, both cause a dose-related bronchoconstriction that is enhanced by exercise, participation in this year's Olympic Games could present some hazards for athletes with allergies or asthma, suggests Kenneth D. Fitch, MB, Department of Sports Medicine, University of Western Australia, Perth. He spoke at the "International Symposium on Special Problems and Management of Allergic Athletes," conducted in Palm Springs, Calif, by the American Academy of Allergy and Immunology; the Associated Scientists To Help Minimize Allergies (ASTHMA) Inc, a nonprofit clinic that treats allergic and asthmatic problems; and the University of Washington, Seattle. According to Fitch, during the 1980 summer games, 21
BOOK REVIEWS
Journal: Circulation Research (1960)

This volume consists of translations of seven articles outlining the authors' experiences in the therapy of various conditions in aged patients by intramuscular and intravenous injections of prociiino.These papers originally appeared in Die Thereapiewoche in 1956-1957.The authors report in glowing terms of their success in treating and preventing the aging process.Procaine is alleged to produce remissions of the chronic brain syndrome due to arteriosclerotic cerebrovascular disease, a.rteriosclerotie heart disease, and arteriosclerotic peripheral vascular disease.In addition, the authors claim such diverse conditions as Parkinson's disease, peptic ulcer, osteoarthritis, senile skin degeneration, among others, are improved by procaine injections.The authors postulate that procaine exerts an "eutrophic" action by acting as a vitamin-like substance or by a gradual transformation into para-aminobenzoic acid and folic acid.The case histories of many patients who are alleged to have been improved by this therapy are given.
Abstract 2804: Early Invasive Management of Acute Coronary Syndromes without ST-elevation: Relation between Rate of Invasive Therapies and Very Long-term Mortality in the Randomized Trials
Authors: Freek W Verheugt, Marc A Brouwer
Journal: Circulation (2007)

Background Randomized trials evaluating an early invasive against a conservative strategy show a benefit over a conservative approach in the composite of death, MI and revascularisation/recurrent ischemia. However, the rate of invasive therapies differed significantly in the trials. Moreover, there were also large differences in the rate of invasive therapies in the invasive versus the conservative arms ( cross-over rate) in the different studies. Therefore we studied the differences in rate of invasive therapy in the study arms of the above trials, and correlated them with the benefit of the invasive therapy with regard to the very long-term mortality as recently published. Methods and Results We analyzed very long-term mortality (30,932 patient-years) in the 9 trials carried out between 1996 and 2004, which randomized 10,558 patients with non-ST-elevation acute coronary syndromes to an early invasive or an ischemia-guided conservative strategy. Differences in the revascularization rate between the invasive and conservative strategies in the trials ranged between 10% and 39%. There was no relation of the differences in revascularization between invasive and conservative strategies and the benefit on mortality whatsoever (see figure ). Conclusion Although most trials on non ST-elevation ACS reported a reduction in the composite of death, MI and revascularisation/ recurrent ischemia, an early invasive strategy does not lead to improved survival on the very long-term. There seems no relation between the difference in revascularisation rate and benefit on the very long term, which may explain the lack of efficacy of early intervention on very long-term mortality.
An algorithm for managing bilateral lung masses
Authors: J. R. Roberts, D. Schumaker
Journal: Journal of Clinical Oncology (2004)

7371 Background: Ten percent of patients with NSCLC present with bilateral masses. Often these lesions are considered to be metastatic, but may be benign, or a separate primary. Resection is best for benign lesions or separate primaries, but poor therapy for metastases. We report 36 patients with bilateral lung masses on whom we first performed mediastinoscopy. If mediastinal nodes were benign, we then resected both lesions. The resulting data allow the generation of an algorithm to manage patients with bilateral lung masses. Methods: Seventy patients were gleaned from 115 fifteen patients with bilateral lung masses. The CT reports of these patients were read as highly suspicious for malignancy. After negative mediastinoscopy, 36 patients remained, all of whom underwent bilateral resections. Survival was determined for those with "Same Path" in both lesions, "Different Path", and "One Benign." Student's t test was used to compare means, and chi-square to compare proportions. Results: There were no differences in the average age of the patients in the three groups. There were striking differences in the survival between those with one benign lesion and those with the same pathology in both lesions (p=0.004). Those patients with different pathologies in each mass had intermediate survival. Conclusions: Our experience demonstrates that patients with similar pathology in bilateral lung masses have very low survival at 24 months, and should not be treated with resection. Patients with bilateral masses should first undergo staging workup and mediastinoscopy. If those are negative, thoracoscopic wedge resection of the smaller lesion combined with needle aspiration of the larger lesion will identify those patients with identical pathology. The larger mass can then be treated with chemoradiotherapy. Patients who are found to have a benign lesion or different pathology should undergo resection. No significant financial relationships to disclose.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1958)

COMMITTEE ON MATERNAL WELFAREFatal Anesthetic AccidentA twenty-four-year-old gravida 2 died from an anesthetic accident in a hospital where nurses customarily give the anesthesia for delivery.She was admitted to the hospital at term at 3:30 a.m. after two hours of labor and ruptured membranes at home. After preparation she was given 0.28 gm. (4 1/2 gr.) of pentobarbital by mouth and transferred to the delivery room within fifteen minutes with the perineum bulging. Twenty-five minutes later the doctor arrived and found the patient having whiffs of ether with her pains, since she apparently had no analgesic, effect from . . .
Chicago College of Pharmacy.
Authors: J W Mill
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Community care of long stay psychiatric patients presents few problems
Journal: BMJ (1999)

Community care of long stay psychiatric patients presents few problems Some attribute the increasing number of homeless people in Britain and the high profile killings by mentally ill people to the closure of psychiatric hospitals and the lack of alternative care.On the basis of a 13 year follow up study, Trieman et al (p 13) show the outcomes for former patients of two psychiatric hospitals and dispel some of the main concerns about their fate in the community.The authors say that a change in policy towards custodial care is unjustified as much as it is unrealistic.
'Silent' Infarcts Are Frequent And Serious, Framingham Study Reveals
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VACATIONS AND DIARRHEA
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Idiopathic Hypovolemia
Authors: FETNAT M. FOUAD
Journal: Annals of Internal Medicine (1986)

Eleven patients with orthostatic intolerance had, for no detectable reason, a marked reduction in blood volume (73 ± 2.29% [SE] of normal). Head-up tilt caused a pronounced increase in heart rate ( + 39 ± 6 beats/min); one patient had a vasovagal episode after the initial tachycardia. Extensive diagnostic study excluded pheochromocytoma, hypoaldosteronism, or any obvious cause for hypovolemia (total plasma catecholamines, 372 ± 53 ng/L; plasma aldosterone level, 14.5 ± 2.56 ng/100 mL; plasma cortisol level, 18.5 ± 2.4 ng/100 mL). The supine hemodynamic pattern (decreased cardiac output and increased total peripheral resistance with normal ejection fraction and mean transit time) was markedly different from that of hyperbeta adrenergic states. Acute plasma volume expansion (+11 ± 2%) in ten patients using human serum albumin improved both their symptoms and heart rate response to tilt. After longterm blood volume expansion with florinef (E.R. Squibb, Princeton, New Jersey), 0.1 mg twice a day, and a high-salt diet, the head-up tilt test was repeated in five patients. The response was normal in four patients. These observations outline a syndrome of marked idiopathic hypovolemia with symptomatic labile hypertension and intolerance to head-up tilt, alleviated by volume expansion.
S112 Long-term safety and efficacy of ivacaftor in pediatric patients aged 2-5 years with cystic fibrosis and a cftr gating mutation
Journal: Thorax (2016)

AbstractJC Davies has served on advisory boards, undertaken educational activities, and served as national/site principal investigator for trials, for which her institution has received funding from Vertex Pharmaceuticals Incorporated. S Robertson is an employee of Vertex Pharmaceuticals Incorporated and may own stock or stock options in that company.J Cooke is an employee of Vertex Pharmaceuticals Incorporated and may own stock or stock options in that company.M Higgins is an employee of Vertex Pharmaceuticals Incorporated and my own stock or stock options in that company.M Rosenfeld: has served as a national and site investigator for trials and as a consultant, for which her institution received funding from Vertex Pharmaceuticals Incorporated.
Hotel Rwanda
Authors: Chloe Veltman
Journal: BMJ (2005)

Directed by Terry George On release in the United States and Canada UK release date yet to be announced www.hotelrwanda.com Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> A bout halfway through Terry George's Hotel Rwanda , Paul Rusesabagina, a hotelier and the central character in the film, steps out of a van that has been run off the road in thick fog one morning, to find himself nose to nose with a corpse. Stumbling to his feet in the swirling mist, he realises that he is staring not just at one cadaver but a landscape strewn with lifeless, bloodied bodies. More than 10 years have passed since the Rwandan genocide, in which some 800 000 Tutsi and moderate Hutu Rwandans were methodically hunted down and murdered by government-backed Hutu extremists, while … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
INNV-22. LIQUID BIOPSY DETECTION OF GENOMIC ALTERATIONS IN PEDIATRIC BRAIN TUMORS FROM CELL FREE DNA IN PERIPHERAL BLOOD, CSF, AND URINE
Authors: Mélanie Pages, Denisse Rotem, Gregory Gydush, Sarah Reed, Justin Rhoades, Gavin Ha, Chris Lo, Adam Tracy, Robert Jones, Sarah Becker, Michaela Haller, Susan Chi, Mark Kieran, Liliana Goumnerova, J Christopher Love, Keith Ligon, Pratiti Bandopadhayay, Karen Wright, Viktor A Adalsteinsson, Rameen Beroukhim
Journal: Neuro-Oncology (2018)

Brain tumors often require invasive neurosurgical procedures for diagnosis and tissue acquisition to guide precision medicine. Detection of tumor-derived cell-free DNA (cfDNA) would facilitate tumor profiling without risk of surgery-related morbidity and provide a means of tumor surveillance. Our aim is to validate a sample collection procedure and develop highly sensitive and specific methodologies to detect tumor-derived cfDNA in CSF, plasma and urine from pediatric patients with brain tumors to identify clinically relevant genomic alterations. Since July 2016, we have prospectively collected blood, urine and CSF samples from 235 patients across all histological subtypes at Dana-Farber Cancer Institute/Boston Childrens Hospital. In parallel, we sequenced the tumors to identify tumor-specific genomic alterations. We optimized a method to process cfDNA and perform ultra-low pass whole genome sequencing (ULP-WGS) using unique molecular identifiers, confirming we can reliably construct sequencing libraries from CSF-, plasma- and urine-derived cfDNA. ULP-WGS has also been used to assess sequencing library quality, copy number variations (CNVs) and tumor fraction. The vast majority of samples undergoing ULP-WGS exhibited no CNVs, consistent with either absence in the tumor or low levels of tumor-derived cfDNA. To distinguish between these, we developed a hybrid capture sequencing panel covering 46 genes, allowing identification of specific mutations and fusions more common in pediatric brain tumors. We are currently assessing the specificity and sensitivity of our assays for detection of tumor-derived cfDNA by sequencing samples with matched tumor NGS available. Furthermore, we are identifying cases with multiple time points of cfDNA, for which data from paired pre- and post-treatment tumors are available, to apply. Our results will provide insights regarding the feasibility of cfDNA assays to guide clinical care in children with brain tumors.
Systemic and splanchnic hemodynamic features of patients with porto-sinusoidal disease as compared with cirrhosis
Authors: Nicolas Drilhon, Valérie Paradis, Shantha Valainathan, Lazareth Marie, Olivier Roux, Clement Lejealle, Payance Audrey, Marion Jager, Hortense Davy, François Durand, Didier Lebrec, Aurélie Plessier, Dominique Valla, Pierre-Emmanuel Rautou
Journal: Journal of Hepatology (2020)
Papers Read in the Sections.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malignant Biliary Obstruction Secondary To Metastatic Bladder Cancer - An Uncommon Presentation Of Cholangitis
Authors: D Buckley, RS O’Neill
Journal: Endoscopy (2021)

Corrected by:Malignant Biliary Obstruction Secondary To Metastatic Bladder Cancer - An Uncommon Presentation Of CholangitisEndoscopy 2021; 53(S 01): C4DOI: 10.1055/s-0041-1729137
The OECD Program to Validate the Rat Uterotrophic Bioassay to Screen Compounds for in Vivo Estrogenic Responses: Phase 1
Authors: Jun Kanno, Lesley Onyon, Joseph Haseman, Penelope Fenner-Crisp, John Ashby, William Owens
Journal: Environmental Health Perspectives (2001)

The Organisation for Economic Co-operation and Development has completed the first phase of an international validation program for the rodent uterotrophic bioassay. This uterotrophic bioassay is intended to identify the in vivo activity of compounds that are suspected agonists or antagonists of estrogen. This information could, for example, be used to help prioritize positive compounds for further testing. Using draft protocols, we tested and compared two model systems, the immature female rat and the adult ovariectomized rat. Data from 19 participating laboratories using a high-potency reference agonist, ethinyl estradiol (EE), and an antagonist, ZM 189,154, indicate no substantive performance differences between models. All laboratories and all protocols successfully detected increases in uterine weights using EE in phase 1. These significant uterine weight increases were achieved under a variety of experimental conditions (e.g., strain, diet, housing protocol, bedding, vehicle). For each protocol, there was generally good agreement among laboratories with regard to the actual EE doses both in producing the first significant increase in uterine weights and achieving the maximum uterine response. Furthermore, the Hill equation appears to model the dose response satisfactorily and indicates general agreement based on calculated effective dose (ED)(10) and ED(50) within and among laboratories. The feasibility of an antagonist assay was also successfully demonstrated. Therefore, both models appear robust, reproducible, and transferable across laboratories for high-potency estrogen agonists such as EE. For the next phase of the OECD validation program, both models will be tested against a battery of weak, partial estrogen agonists.
Correction: <i>Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial—mesenchymaltransition</i>
Journal: Gut (2021)

The representative images of SW116-EIF5A2-sic-myc cells in Migration assay of Figure 6C lower right and Invasion assay of Figure 6D right is incorrect.The correct figure 6 is shown below.The figure legend remains the same.