tbuckley/cabot-search huggingface dataset:
A pilot study of concurrent chemotherapy (teniposide and carboplatin) combined with whole brain radiotherapy in non-small cell lung cancer patients with brain metastases
Authors: D. M. Kowalski, M. J. Krzakowski, P. Jaskiewicz, K. Zajda, M. Wierzchowski, T. Denisso
Journal: Journal of Clinical Oncology (2004)

7332 Background: Brain metastases will developed in 5–10% of patients with non-small cell lung cancer at the time of diagnosis. The development of brain metastases is associated with considerable morbidity. The mainstay of treatment is palliative whole radiotherapy (WBRT). A phase II trial was performed to evaluate efficacy and toxicity of concurrent whole brain radiotherapy with systemic chemotherapy in previously untreated patients with non-small cell lung cancer and multiple brain metastases. Methods: Twenty seven entred the trial between June 1999 and December 2003. The patients received WBRT 30 Gy in 10 fractions and carboplatin was administred according Calvert formula (AUC 6) an day 1 of radiotherapy with teniposide 100 mg/m2 on day 1 and 3. Results: All the patients finished scheduled treatment regiment and were evaluable for responce: one had a complete response (CR) in brain, nine achived a partial response (PR), twelve had a stable disease (SD) and two progressed while on treatment. The time to progression to disease was 19,2 weeks (range: 4–72 weeks). The median overall survival time was 35 weeks (range: 4–100 weeks). The main toxicity was hematological: neutropoenia, thromocytopoenia, anaemia. Conclusions: The promising results of this pilot study deserve confirmation in phase III randomised study in more numerous group of patients. No significant financial relationships to disclose.
Lithium carbonate treatment in depression and mania
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ki-67 expression during rat liver regeneration after partial hepatectomy
Authors: C Gerlach
Journal: Hepatology (1997)

Antibodies to the cell-cycle-associated Ki-67 protein have been widely used for more than a decade as markers of proliferative cells. The prototype antibody Ki-67 reacted only with snap-frozen human tissue, but a novel antibody, MIB-1, was able to detect the Ki-67 antigen in paraffin wax-embedded human tissue. The ability of MIB-5, a novel antibody reactive with the rat equivalent Ki-67 protein, to immunohistochemically detect cycling parenchymal and littoral cells in the regenerating rat liver is reported. Rats underwent a standard two-thirds partial hepatectomy (PH), and groups of three animals were killed at intervals for up to 192 hours after PH. DNA synthesis was monitored by flash labeling with bromodeoxyuridine, and the response was as expected with a significant upsurge in hepatocyte labeling at 16 to 17 hours after PH. On the other hand, MIB-5 labeled a relatively constant percentage of hepatocytes (4%-8%) during the first 16 hours after PH, before a large proportion became labeled, also at 17 hours. The temporal pattern of MIB-5 labeling was similar to that of bromodeoxyuridine labeling, although, as expected, MIB-5 indices were higher. Semiquantification of Ki-67 messenger RNA (mRNA) levels by reverse-transcription polymerase chain reaction showed modest (fourfold to fivefold) increases in abundance during the first 12 hours after PH, but then levels increased dramatically to be at least 15-fold those of intact liver at 36 hours after PH. Much higher than normal levels of Ki-67 mRNA persisted throughout the period of study and even at 96 hours after PH they were still ninefold greater than normal. This study has shown the usefulness of the MIB-5 antibody to monitor proliferation in the rat liver, and furthermore, the pattern of expression of both the mRNA and the protein suggest that the Ki-67 protein, with hitherto unknown function, is more abundant in DNA synthesis and mitosis than in the early or even very late first G1 phase.
Saccharin
Authors: Sanford A Miller, Victor P Frattali
Journal: Diabetes Care (1989)

Saccharin, a nonnutritive sweetener discovered in 1879, has been the subject of controversy concerning its effect on public health on several occasions during this century. Over this period, the substance has come to be regarded as a useful commodity in the dietary management of diabetes mellitus. We review the historical and scientific background on the subject and proposea new approach in making public-health decisions on unique foods that serve a special dietary purpose.
Guidelines for providing medical care to Southeast Asian refugees
Authors: G. N. Hoang
Journal: JAMA (1982)

Almost 500,000 Southeast Asian refugees have arrived in the United States since 1975. While these refugees have not presented substantial public health problems, they have important personal health problems frequently requiring medical attention. Medical care providers in this country need to be aware of disease patterns and prevalence among these refugees. As well, they need to be aware of the cultural and religious backgrounds and previous medical practices of this refugee population, particularly as these practices influence the refugees' ability to obtain and maintain medical services provided in this country. Historical, cultural, religious, ethical, and medical information is provided to help US health care facilities develop culturally appropriate medical care services for Southeast Asian refugees. (<i>JAMA</i>1982;248:710-714)
Contralateral orchiopexy at the time of urgent scrotal exploration: is it safe? A propensity score matched analysis from the TORSAFUF cohort
Authors: I. Duquesne, U. Pinar, F. Lannes, M. Felber, F. Bardet, K. Kaulanjan, C. Michiels, E. Seizilles De Mazancourt, I. Dominique, V. Maxime, B. Gondran-Tellier, L. Freton, Z-E. Khene, B. Pradere
Journal: European Urology (2021)
Community Pediatrics
Authors: Robert J. Haggerty
Journal: New England Journal of Medicine (1968)

A NEW term, community pediatrics, is abroad in the land. In the first decade after World War II the then new term was comprehensive pediatrics, which was applied to a variety of new pediatric educational and care programs. The current shift to the term "community" represents more than a change of fashion. Comprehensive pediatrics is concerned with provision of health services to meet all the medical needs of a given child who comes for medical attention. It is patient oriented rather than disease oriented. The new concept in community pediatrics, and its major distinction from comprehensive pediatrics, adds to this . . .
A POSSIBLE CHECK TO QUACKERY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Esophageal and Gastric Tumors
Authors: H Inoue
Journal: Endoscopy (2001)

In the diagnosis of early cancer, there are differences in the pathological criteria used by Western and Asian (Japanese) pathologists. The Vienna classification advocated by pathologists offers standard pathological criteria common to all endoscopists, and it has clarified the indications for the treatment of superficial lesions, including high-grade dysplasia and mucosal cancer.
Setting Environmental Agendas: The Search for Common Ground
Authors: Betty Mushak
Journal: Environmental Health Perspectives (1993)

Research ArticleOpen AccessSetting environmental agendas: the search for common ground. B Mushak B Mushak Search for more papers by this author Published:22 April 1993https://doi.org/10.1289/ehp.9310126AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit FiguresReferencesRelatedDetails Vol. 101, No. 1 April 1993Metrics About Article Metrics Publication History Originally published1 April 1993Published in print22 April 1993 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.
Pediatrics
Authors: M. Heins
Journal: JAMA (1989)

Both the specialty of pediatrics and the children it serves have benefited from the recent advances in biomedical science and technology. Each year brings new triumphs—but regrettably also brings tragedies, which can be defined as a greater discrepancy between the gains for some children and the status quo (or worse) for others. First, the triumphs. Advances in molecular genetics are impacting on clinical pediatrics. The gene for cystic fibrosis has been located on chromosome 7 and antenatal diagnosis, using linked DNA probes of fetal DNA from chorionic villi sampling, is now possible in more than two thirds of parents with an affected child. Sickle cell anemia can also be diagnosed before birth; a new restrictive enzyme technique can make the diagnosis in a day.<sup>1</sup>Recent gene mapping studies have shown that the gene frequency of nonclassical adrenal hyperplasia is more common than cystic fibrosis in white populations.<sup>2</sup>Gene replacement
THE LAW OF AGENCY—A COMPARISON.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WITHOUT PREJUDICE
Authors: None Pertinax
Journal: BMJ (1963)

Without PrejudiceIt is irritating not to be able to trace the source of a quotation, because, apart from anything else, one cannot check its accuracy.I have for long envied the reckless abandon of a friend of mine who in the course of an impromptu speech will father quotations of his own on to any well-known name that comes into his head at the time.Gladstone is one of his favourites." As Gladstone said- I think it was in 1880-Democracy means the choice of an alternative.
Two ecNOS polymorphisms are associated with previous myocardial infarction but not with increased progression of coronary atherosclerosis Willem R. P. Agema, Johan W. Jukema, Moniek P. M. de Maat, Joram de Kraker, Aeilko H. Zwinderman, John J. P. Kastelein, Ton J. Rabelink. Leiden University Medical Center, Leiden, The Netherlands, TNO-PG Gaubius Laboratory, Leiden, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
AMA RESEARCH FORUM
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spotlight Issue on Mechanisms of Angiogenesis and Remodeling of the Microvasculature
Authors: Alain Tedgui, Bernard Lévy, Jean-Sébastien Silvestre
Journal: Cardiovascular Research (2007)

A Spotlight Issue on mechanisms of angiogenesis and remodeling of the microvasculature is scheduled to appear in May, 2008, that will address the cellular and molecular mechanisms involved in new vessel growth in both physiological and pathological settings.Identification and definition of these mechanisms should lead to the development of therapeutic strategies designed to promote revascularization in patients with ischemic diseases.Preliminary topics of invited review articles related to the angiogenesis and the microvasculature include:
Pulse
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Michael A. Tighe
Journal: New England Journal of Medicine (1946)

REVIEW LECTURE COURSEThe review lecture course for physicians in the Boston area that has been arranged by the Subcommittee on Postgraduate Medical Education of the Postwar Planning Committee, Massachusetts Medical Society, in co-operation with the Massachusetts Department of Public Health, will begin on February 18. The meetings will be held at Sanders Theater in Memorial Hall, Harvard University, Cambridge. These lectures, which are primarily designed for general practitioners and former medical officers, will review progress in medicine during the past four or five years. The speakers have been urged to present their subjects in a simple and direct manner . . .
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
Authors: Stuart P. Weisberg, Deborah Hunter, Reid Huber, Jacob Lemieux, Sarah Slaymaker, Kris Vaddi, Israel Charo, Rudolph L. Leibel, Anthony W. Ferrante Jr.
Journal: Journal of Clinical Investigation (2005)

The C-C motif chemokine receptor–2 (CCR2) regulates monocyte and macrophage recruitment and is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis. Although adipose tissue expression and circulating concentrations of CCL2 (also known as MCP1), a high-affinity ligand for CCR2, are elevated in obesity, the role of CCR2 in metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation associated with obesity, has not been studied. To determine what role CCR2 plays in the development of metabolic phenotypes, we studied the effects of Ccr2 genotype on the development of obesity and its associated phenotypes. Genetic deficiency in Ccr2 reduced food intake and attenuated the development of obesity in mice fed a high-fat diet. In obese mice matched for adiposity, Ccr2 deficiency reduced macrophage content and the inflammatory profile of adipose tissue, increased adiponectin expression, ameliorated hepatic steatosis, and improved systemic glucose homeostasis and insulin sensitivity. In mice with established obesity, short-term treatment with a pharmacological antagonist of CCR2 lowered macrophage content of adipose tissue and improved insulin sensitivity without significantly altering body mass or improving hepatic steatosis. These data suggest that CCR2 influences the development of obesity and associated adipose tissue inflammation and systemic insulin resistance and plays a role in the maintenance of adipose tissue macrophages and insulin resistance once obesity and its metabolic consequences are established.
PERITONEAL SUPPORTS—(LIGAMENTUM PERITONEI).
Authors: BYRON ROBINSON
Journal: JAMA (1895)

In my opinion to Meckel belongs the chief credit of the coalescence theory (1817) and Müller in 1830 simply confirmed his views and enlightened the world as to the origin and development of the great omentum. Yet it is not necessary to believe that even such celebrated men as Meckel and Müller could not make mistakes. I have read with care and pleasure Müller's article on the "Origin of the Great Omentum," written in German in 1830. I find that even Müller could labor under errors. For example, Müller states that the mesogaster ceases at the point where the duodenum begins. Any one can easily disprove this statement by opening a human embryo at six weeks or, still better, a dog or cat, whence in all three cases it will be plain and easy to see that the mesogaster extends all the way down the duodenum to the junction with
New disease prevention effort goes by the book
Authors: C. Marwick
Journal: JAMA (1994)

"PPIP," says the Department of Health and Human Services (HHS), announcing a new nationwide campaign to "increase the healthy life spans of Americans by making disease prevention a standard part of medical practice." The initials stand for Put Prevention Into Practice, and the department's chief medical officer, Philip R. Lee, MD, assistant secretary for health, describes the effort as "nothing less than reforming medical care and extending healthy life by shifting primary care practices toward prevention." The HHS is issuing a 400-page textbook entitled<i>Clinician's Handbook of Preventive Services</i>, intended for primary care providers including nurse practitioners, physicians' assistants, pediatricians, internists, and family physicians. The book is in two parts, one dealing with children and adolescents and the other with adults. Each part has three sections: screening, immunizations and prophylaxis, and counseling. An introductory overview contains a handy preventive care timeline chart that indicates how frequently tests or examinations should
For Morrie
Authors: Annette Hollander
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal