tbuckley/cabot-search huggingface dataset:
CCR4-bearing T cells participate in autoimmune diabetes
Authors: Soon H. Kim, Mary M. Cleary, Howard S. Fox, David Chantry, Nora Sarvetnick
Journal: Journal of Clinical Investigation (2002)

Chemokine receptor expression is exquisitely regulated on T cell subsets during the course of their migration to inflammatory sites. In the present study we demonstrate that CCR4 expression marks a pathogenic population of autoimmune T cells. CCR4 was found exclusively on memory CD4+ T cells during the progression of disease in NOD mice. Cells expressing the CCR4 ligand TARC (thymus- and activation-regulated chemokine) were detected within infiltrated islets from prediabetic mice. Interestingly, neutralization of macrophage-derived chemokine (MDC) with Ab caused a significant reduction of CCR4-positive T cells within the pancreatic infiltrates and inhibited the development of insulitis and diabetes. Furthermore, enhanced recruitment of CCR4-bearing cells in NOD mice resulting from transgenic expression of MDC resulted in acceleration of clinical disease. Cumulatively, the results demonstrate that CCR4-bearing T cells participate in the development of such tissue-driven autoimmune reactions.
Hepatitis B vaccine use in chronic hemodialysis centers in the United States
Authors: M. J. Alter
Journal: JAMA (1985)

The Centers for Disease Control surveyed 1,255 chronic hemodialysis centers in the United States in 1983 to assess the use of hepatitis B vaccine as well as the risk of acquiring hepatitis B among both patients and staff. The response rate to a mailed questionnaire was 90%. Seventy-one percent of the centers reported that they gave vaccine, but only an estimated 6% of susceptible patients and 32% of susceptible staff received all three doses of vaccine. Centers more likely to give vaccine included those that provided dialysis to large patient populations and those that provided dialysis for hepatitis B surface antigen-positive patients. As a result of vaccine administration, the overall prevalence of antibody to hepatitis B surface antigen increased significantly, to 18% for patients and 39% for staff. Extensive use of the vaccine in the future, combined with infection control practices, could virtually eliminate the risk of acquiring hepatitis B virus infection in hemodialysis centers. (<i>JAMA</i>1985;254:3200-3202)
Serious complications due to study-mandated liver biopsies in phase 3 trials for patients with advanced fibrosis due to non-alcoholic steatohepatitis
Authors: Quentin Anstee, Keyur Patel, Castera Laurent, Mitchell Shiffman, Mang M, Chi-Yi Chen, Boon Bee George Goh, William Alazawi, Ling Han, Kathryn Kersey, Marianne Camargo, Robert Myers, Manuel Romero Gomez, Stephen Harrison, Michael Trauner, Vincent Wai-Sun Wong, Takeshi Okanoue, Eric Lawitz, Zobair M. Younossi, Arun Sanyal
Journal: Journal of Hepatology (2020)
Arthritis associated with calcium oxalate crystals in an anephric patient treated with peritoneal dialysis
Authors: A. Rosenthal
Journal: JAMA (1988)

We report a case of calcium oxalate arthropathy in a woman undergoing intermittent peritoneal dialysis who was not receiving pharmacologic doses of ascorbic acid. She developed acute arthritis, with calcium oxalate crystals in Heberden's and Bouchard's nodes, a phenomenon previously described in gout. Intermittent peritoneal dialysis may be less efficient than hemodialysis in clearing oxalate, and physicians should now consider calcium oxalate-associated arthritis in patients undergoing peritoneal dialysis who are not receiving large doses of ascorbic acid. (<i>JAMA</i>1988;260:1280-1282)
Abstract LB-101: Combined p53 dynamics and post-translational modifications determine subsequent protein expression and cell fate
Authors: Dan Lu, Kristina Holton, Antonina Hafner, Caroline DeHart, Jacek Sikora, Houjiang Zhou, Ashwini Jambhekar, Neil Kelleher, Jeremy Gunawardena, Galit Lahav
Journal: Cancer Research (2019)

Abstract The tumor suppressor protein p53 is activated by a diverse repertoire of cellular stresses (e.g. oncogenic signalling, DNA damage) and as a transcription factor induces the expression of response pathways genes (including cell cycle arrest, senescence, apoptosis). While p53 is frequently lost during tumorigenesis, approximately 50% of human tumors retain intact p53, potentially rendering them sensitive to p53-induced cell death during radiotherapy. Recent single cell analysis from our lab has shown that irradiation of cells does not cause a simple sustained accumulation of p53, but rather, induces pulsatile p53 dynamic that oscillates at 5-hour periods resulting from a p53-Mdm2 negative feedback loop, leading to reversible cell cycle arrest. Disrupting this feedback loop by small molecules results in sustained p53 dynamics, leading to irreversible apoptosis or senescence. Moreover, extensive work by others has shown that post-translational modifications (PTM) on p53 also govern the cell fate decision process. Here we show that aside from differences in p53 dynamics following irradiation, multiple PTMs on p53 also differ, with the latter causing quantitative changes of p53 binding to interactions proteins and subsequent alterations in promoter binding. In contrast, p53 dynamics govern broad transcription dynamics of target genes. For example, pulsatile p53 dynamics result in several distinct patterns of mRNA transcription including a cluster of oscillating p53 target genes. However, these oscillatory mRNA dynamics are lost at the protein level. The only p53 target protein that oscillates is the Mdm2 negative regulator of p53, while all other targets gradually accumulate over time. Furthermore, sustained p53 dynamics over 24h results in far greater accumulation of nearly all target proteins compared to pulsatile p53 dynamics, which likely explains the differences in the reversibility of cell fate decisions. The results described here uncover a link between p53 dynamics and p53 PTMs providing an overall mechanistic cell fate selection process by p53, which have important implications both for understanding of cell signalling processing as well as improving p53-mediated therapies. Citation Format: Dan Lu, Kristina Holton, Antonina Hafner, Caroline DeHart, Jacek Sikora, Houjiang Zhou, Ashwini Jambhekar, Neil Kelleher, Jeremy Gunawardena, Galit Lahav. Combined p53 dynamics and post-translational modifications determine subsequent protein expression and cell fate [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-101.
Leads from the MMWR. Changing patterns of groups at high risk for hepatitis B in the United States
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antistreptococcal Prophylaxis
Authors: Harry A. Feldman
Journal: JAMA (1967)

<h3>To the Editor:—</h3> One of the more gratifying developments of recent years has been the increasing application of modern, sophisticated techniques to medical research. It should be expected that the major by-product of their employment is to benefit the patient for whom the physician may be able to provide more effective and rational therapeutic procedures. Unfortunately, sophistication of methodology does not of itself guarantee that such will be the case. An illustration of this is the paper by Feinstein et al, entitled "Discontinuation of Antistreptococcal Prophylaxis" (<b>197</b>:-949, 1966). Despite careful selection of patients, their division into groups of comparable makeup, detailed observations, and preciseness of the mathematical calculations on the relative effectiveness of drug treatment and a placebo, this report, unfortunately, is susceptible to significant criticism. The effect of the exhibition of a therapeutic agent is not an all-or-none phenomenon. That one group of patients received penicillin and the
Reference Error
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic and therapeutic technology assessment. Penile implants for erectile impotence
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Table of Contents
Authors: Beatriz Domínguez-Gil, Marta López-Fraga, Elmi Muller, John Gill, Madhav Menon, Peter Heeger, Christina Wyatt, Steven Crowley, Yoshitaka Isaka, W Charles O'neill, Tri-Long Nguyen, Paul Landais, V Knoers, Rajeev Rohatgi, Michael Ross, Sandawana Majoni, Haojia Wu, Benjamin Humphreys, Ana Pimentel, Pablo Ureña-Torres, M Zillikens, Jordi Bover, Martine Cohen-Solal, Yasuyuki Shinozaki, Kengo Furuichi, Tadashi Toyama, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Shuichi Kaneko, Noriyoshi Isozumi, Shushi Nagamori, Yoshikatsu Kanai, Tomoko Sugiura, Yukio Kato, Takashi Wada, Hanako Kobayashi, Jiao Liu, Andres Urrutia, Mikhail Burmakin, Ken Ishii, Malini Rajan, Olena Davidoff, Zubaida Saifudeen, Volker Haase, Luis Hortells, Cecilia Sosa, Natalia Guillén, Susana Lucea, Ángel Millán, Víctor Sorribas, Jin Beom, Jae Lim, Jun Yang, Jianyong Zou, Taiji Zhong, Ira Matsusaka, Ming-Zhi Pastan, Raymond Zhang, Hai-Chun Harris, Agnes Yang
Journal: Kidney International (2017)
Secondary leukemia
Authors: Henrik Hasle
Journal: HemaSphere (2018)

Aarhus University Hospital, Denmark This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Cardiac Adults
Authors: Zud Babar, Y Ganushchak, Npa Vranken, Rhj Hendrix, Tsr Delnoij, R Lorusso, P Weerwind, Tomáš Bou Ček, Petra Krupi Čková, Zuzana Mormanová, Michal Huptych, Tomáš Belza, Ondřej Šmíd, Aleš Král, Hana Skalická, Aleš Linhart, Jan Ělohlávek, Daniele Camboni, Alois Philipp, Lukasz Kmiec, Bernhard Flörchinger, Thomas Müller, Matthias Lubnow, York Zausig, Christof Schmid, Feng Yang, Dengbang Hou, Xiaotong Hou, Brendan Murfin, Nicholas Barrett, Luigi Camporota, Guy Glover, Christopher Langrish, Christopher Meadows, Andrew Retter, Stephen Tricklebank, Duncan Wyncoll, Nicholas Ioannou
Journal: European Journal of Heart Failure (2017)
Erroneous reporting of errors
Authors: W. D. Clark
Journal: JAMA (1984)

<h3>In Reply.—</h3> I am most grateful to Drs Clark and Quinn. They have forced me to reread my source. When a 14-year-old publication is not reviewed, one deserves egg on one's face. William B. Ober, in the<i>Pathology Annual</i>of 1970, discusses the case of Frederick III of Prussia's cancer. My most vivid memory was his mention of "the clash of personalities between Mackenzie and the German physicians." Review of the paper shows that Mackenzie and Virchow were, indeed, of the same opinion. In 1886, the surgeons consulted considered the lesion to be cancer. At this point, Bismarck intervened and pressed for further consultation before the operation (possibly laryngofissure) was undertaken. Morell Mackenzie was called in (via the Crown Princess to her mother [Queen Victoria] by Sir James Reid, the Queen's resident physician). Mackenzie, appropriately, did a biopsy of the lesion several times, and Virchow could not make a diagnosis
Generation Gap
Authors: Charles D. Aring
Journal: JAMA (1972)

"Some day, maybe, there will exist a well-informed, wellconsidered, and yet fervent public conviction that the most deadly of all possible sins is the mutilation of a child's spirit; for such mutilation undercuts the life principle of trust, without which every human act, may it feel ever so good and seem ever so right, is prone to perversion by destructive forms of conscientiousness." Erik Erikson It might be that adults are the inadvertent models of noncommunication between the generations. While the succeeding generations may originate, they hardly do so in a vacuum. "Generation gap" resounds with such frequency these days that it is already a cliché; although, any break between generations, even a break in communication only, could be the swan song of humanity. The formative years are as good a place as any to examine for reasons that the generations do not communicate. Looking back to childhood—and one rarely
Bell's palsy and herpes simplex.
Authors: P Grout
Journal: BMJ (1977)

continuing and expanding research on the treatment of this condition, which is at present responsible for considerable personal distress and social disruption.In view of the large numbers of women between the menarche and the menopause who suffer from PMS any significant reduction in its overall incidence will be welcome and we hope that family doctors will be encouraged to treat PMS by these new approaches.Further help and support from specialised clinics in teaching hospitals and other centres will be required for some time yet, but we hope soon to publish further observations on the clinical presenta- tion of PMS which will minimise this need.
Hormonal control of gene expression in the ovary
Authors: J. S. Richards
Journal: Endocrine Reviews (1994)

Journal Article Hormonal Control of Gene Expression in the Ovary Get access Joanne S. Richards Joanne S. Richards 1Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030 *Address requests for reprints to: JoAnne S. Richards, Ph.D., Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030. Search for other works by this author on: Oxford Academic Google Scholar Endocrine Reviews, Volume 15, Issue 6, 1 December 1994, Pages 725–751, https://doi.org/10.1210/edrv-15-6-725 Published: 01 December 1994
Social Medicine
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of coronary angiography and coronary revascularization before noncardiac vascular surgery
Authors: J. J. Mason
Journal: JAMA (1995)

<h3>Objective.</h3> —To determine whether preoperative coronary angiography and revascularization improve short-term outcomes in patients undergoing noncardiac vascular surgery. <h3>Design.</h3> —Decision analysis. <h3>Patients.</h3> —Patients undergoing elective vascular surgery who had either no angina or mild angina and a positive dipyridamole-thallium scan result. <h3>Interventions.</h3> —Three strategies were compared. The first strategy was to proceed directly to vascular surgery. The second was to perform coronary angiography, followed by selective coronary revascularization, before proceeding to vascular surgery and to cancel vascular surgery in patients with severe inoperable coronary artery disease (CAD). The third was to perform coronary angiography, followed by selective coronary revascularization, before proceeding to vascular surgery and to perform vascular surgery in patients with inoperable CAD. <h3>Main Outcome Measures.</h3> —Mortality, nonfatal myocardial infarction, stroke, uncorrected vascular disease, and cost. All outcomes were assessed within 3 months. <h3>Results.</h3> —Proceeding directly to vascular surgery led to lower morbidity and cost in the base case analysis. The coronary angiography strategy led to higher mortality if vascular surgery would proceed in patients with inoperable CAD, but led to slightly lower mortality if vascular surgery were canceled in patients with inoperable CAD. The coronary angiography strategy also led to lower mortality when vascular surgery was particularly risky. <h3>Conclusions.</h3> —Decision analysis indicates vascular surgery without preoperative coronary angiography generally leads to better outcomes. Preoperative coronary angiography should be reserved for patients whose estimated mortality from vascular surgery is substantially higher than average. (<i>JAMA</i>. 1995;273:1919-1925)
Reports of Societies
Journal: BMJ (1886)

Intussusception.-'Dr.WRLVI'ANSON reSdt iths df a ca of InVt`susception, Ai6sw6td the portion of bowel'remo*ed' tby iopethtlk.i Thre pstient was a; delicate little boy, two'years of -aget On Febt ary -5th 18S,; he paaeed a quantity of blood, Andj soon lftUt, bdgaii to st1aini fkecqtntly at stool, passing nothing but blood' and miius' Two doses of castot--oil were administered by the parents, but were reje5ted by the stornmith.When first seen, oh the evening of the 6th, he was vomiting frequently, and constantly attempting to defawcate.The ab' dremen Was -sft, not di'stended, and free fromni'tenderness, and there was somd f401ts8 in the tbight loin.The recttm waS empty, and an e6mma btouthit away nothing but blood.He"vas given :iul doses of belladoniia a poultice was applied t6 the abdomen* fob Wa's e- sittiMe to barle$r water and milk ; and aperienU we6floridden.odn the 44th;'the symptbms boutinued; but the-obdoniei was now'conl-' dai6ly distehd,e and a distinctly elong9ated trtidui &ould.bfhe lt on' the riht side.7he vomit' was fieeli p1ile'very lapid, and;"teipeta-' tuA subnWwnsA.-Underchlorofor-m, rlumtion'df the obstrctiaon by insts*fatton of bit wabs atteuipted', bet'-Proved' 'a faliure.-Acdrdihgly the hbdomen was opened in the middlo like by ai iihiiojii:' two incheoh' in; length, between the umnbilicus and pubes."CleAr seruiti dgeaipd, and A coil of brightly injected bowel' showed itself.The ittiuscep: tion 'w found ron the fight side, 'and extendeidfroau the cgecutn to the' centre of the transverse' coloA.It was all rediced by mnanpulation;è xcept Abodut two 'inches.As this portion was also Very livid and friable, and tore with even gentle traction, it was excised, and an artificial anus formed.After the operation, opium was given, and the diet restricted to iced-water and barleSr-water., Flatus passed througb.thd wound on the next day,'and a s'olid motion on February th.Voniitibg was troublesome for several days, but ceased when nutrient eneinita were subsbituted for feeding by the mouth, while the general' c6bdition of the patieit improve'd greatly.At midniight, ho*ever, of FeNtuary 12th,'he began to fail.Diarrhea set in, ani*he died on the 14th,'enactly a week after the operation.-Inthe discussion which foll6Twed, 'Drs., Locxin, IRlvm, and ABLETT took part.'Speeiimena-, etc.-Dr.J. R. IRWIN showed the' following specimens'' and, patient:' 1. Obli'que fracture of femur extendibg' 8*' inches' :fromr the tro6hanter 'major towards the inner condyle, caused by falling downstairs.The patient was a female, aged 72.;'tuce, whi siiouGd b# 'ediipoWered to ki''O , if -ce1*#f'tA the School Board.' p1Valley.