tbuckley/cabot-search huggingface dataset:
Analysis of flow-directed pulmonary artery catheterization
Authors: D. H. Spodick
Journal: JAMA (1989)

NOT ALL the maneuvers directed toward benefiting patients necessarily result in<i>net</i>benefit—a situation we readily accept in conscientiously attempting to avoid the toxic effects, complications, and side effects of medical and surgical treatments. Yet, like treatments, invasive diagnostic procedures present complications and side effects that may be less comprehensively appreciated. In this issue ofThe Journal, Carlson and colleagues<sup>1</sup>report pulmonary artery hemorrhage, a rare complication of flow-directed pulmonary artery catheterization, in three patients, one of whom was adroitly treated with therapeutic embolism. While the authors list risk factors for this complication (to which could be added recent cardiopulmonary bypass), their report should be considered in a broader context—that of indications for catheterization and the panoply of recognized complications, summarized in the Table, as well as the poorly understood physiological burden imposed by the presence of intravascular instrumentation itself.<sup>2</sup> <h3>Recognized Complications</h3> The precise incidence of recognizable complications
ACTR-11. SECOND INTERIM AND 1ST MOLECULAR ANALYSIS OF THE EORTC RANDOMIZED PHASE III INTERGROUP CATNON TRIAL ON CONCURRENT AND ADJUVANT TEMOZOLOMIDE IN ANAPLASTIC GLIOMA WITHOUT 1p/19q CODELETION
Authors: Martin van den Bent, Sara Erridge, Michael Vogelbaum, Anna Nowak, Marc Sanson, Alba Brandes, Wolfgang Wick, Paul Clement, Jean-Francais Baurain, Warren Mason, Helen Wheeler, Michael Weller, ken aldape, Pieter Wesseling, Johan Kros, Mircea Tesileanu, Vassilis Golfinopoulos, Thierry Gorlia, Brigitta Baumert, Pim French
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND The 1st interim analysis of the CATNON trial showed benefit from adjuvant (adj) temozolomide (TMZ) on overall survival (OS) but remained inconclusive about concurrent (conc) TMZ. A 2nd interim analysis was planned after 356 events. METHODS The 2x2 factorial design phase III CATNON trial randomized 751 patients with newly diagnosed non-codeleted anaplastic glioma to either 59.4 Gy radiotherapy (RT) alone; the same RT with concTMZ; the same RT and 12 cycles of adjTMZ or the same RT with both concTMZ and adjTMZ (doi: 10.1016/S0140-6736(17)31442–3). MGMT promoter methylation (MGMTmeth) status was re-assessed with the Infinium Methylation EPIC Beadchip. Isocitrate dehydrogenase 1 and 2 (IDH) mutation (mt) status was assessed with a glioma targeted next generation sequencing panel. At the time of molecular analysis, a 3rd database lock was done. RESULTS At the 2nd IDMC (median follow-up 56 months, 356 events observed) the hazard ratio (HR) for OS adjusted for stratification factors after concTMZ was 0.968 (99.1% CI 0.73, 1.28. An IDHmt was found in 368 of 528 assessed cases (70%). After median follow-up of 67 months and with 367 events observed median OS was 19 mo (95% CI 16.3, 22.3) in IDHwt tumors and 116 mo (95% CI 82.0, 116.6) in IDHmt tumors. IDHmt was predictive of benefit from adjTMZ (IDHmt HR: 0.46, 95% CI 0.32, 0.67; IDHwt: HR 1.03, 95% CI 0.73, 1.44; interaction test p = 0.002) and from concTMZ (HR(IDHmt HR: 0.63, 95% CI 0.43, 0.91; IDHwt: HR 1.16, 95% CI 0.83, 1.63; interaction test p = 0.017). MGMTmeth was found in 401 of 478 assessed cases (69%), interaction tests for concTMZ and adjTMZ did not reach statistical significance. CONCLUSIONS In IDHmt tumors adjuvant and concurrent temozolomide improves survival, no effect was observed in IDHwt tumors. Further follow-up and molecular analyses are required for mature analyses.
Abstract of Clinical Lectures, Delivered at St. Bartholomew's Hospital
Authors: J. Paget
Journal: BMJ (1875)

Invariant natural killer T (iNKT) cells are innate-like T cells that secrete a wide array of cytokines and immune mediators. These cells recognize self or microbial ligands presented by cells expressing CD1d, and can contribute to host protection or/and pathogenesis during intestinal inflammation. The colonic iNKT cell population is established in early life under the influence of the microbiota and current understanding is that this iNKT cells are not manipulable in later life. Previous studies have identified that goblet cell associated passages (GAPs) play a role in luminal antigen delivery and the induction and maintenance of peripherally induced T regulatory cells in the steady state. Colonic GAPs are largely absent in adult mice due to goblet cell (GC) microbial sensing, which inhibits GAP formation. We hypothesized, that when present, colonic GAPs may deliver glycolipids to stimulate colonic iNKT cells. We found that the glycolipids can be delivered through GAPs and that inducing colonic GAPs in adult mice using pharmacological inhibitors or transgenic mouse models resulted in significant iNKT cell expansion. Further deletion of CD1d on GCs inhibited iNKT cell expansion suggesting a role for colonic GCs in presenting glycolipids to iNKT cells. Single cell RNA sequencing of sorted colonic iNKT cells showed significantly expanded iNKT2 and iNKT1 subsets after colonic GAP induction. Furthermore, the iNKT cells expanding after opening colonic GAPs were protective in DSS-induced colitis. Our findings suggest that the GAP function and CD1d expression by GCs plays a role in modulating colonic iNKT cell subsets in adulthood and can be protective in some colitis models.
Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1
Authors: Ronald P. van Rij, Hetty Blaak, Janny A. Visser, Margreet Brouwer, Ronald Rientsma, Silvia Broersen, Ana-Maria de Roda Husman, Hanneke Schuitemaker
Journal: Journal of Clinical Investigation (2000)
MS-24 * SYSTEMIC TREATMENT OF MENINGIOMAS: IS THERE A ROLE FOR LONG-ACTING SOMATOSTATIN?
Authors: R. Soffietti, M. Magistrello, E. Trevisan, L. Bertero, A. Pellerino, R. Ruda
Journal: Neuro-Oncology (2014)

BACKGROUND: Meningiomas are the most common primary brain tumors. Resection and/or radiation therapy are the treatments of choice. Medical therapies have been investigated for inoperable, recurrent and aggressive meningiomas, but the optimal medical treatment is still to be defined. Among biologic agents, somatostatin has been found to inhibit meningioma growth due to the presence of somatostatin receptors on the surface of the tumors. AIM: We retrospectively reviewed our experience with sandostatin to assess the efficacy and toxicity in the treatment of recurrent meningiomas failing standard treatments. PATIENTS AND METHODS: A total of 17 patients (7 women and 10 men, median age 65 years) with recurrent grade I or II or III meningiomas have been studied. All patients had already been treated with multiple surgeries or radiation treatments, and all had an overexpression of somatostatin receptors by octreotide scintigraphy. Before treatment KPS ranged from 60 to 90. The patients received long-acting somatostatin on a monthly administration schedule. Radiographic response on MRI has been assessed by MacDonald Criteria. RESULTS: Patients received 3 to 18 cycles (median 9) of somatostatin. Progression-free survival (PFS) at 6 months was 56%, while PFS ranged from 3 to 25 months with a median of 6 months. Two radiological responses on MRI were achieved (1 PR and 1). Toxicity was uncommon and manageable (2 patients with diarrhea). CONCLUSION: Long acting somatostatin displays minor activity as salvage treatment for recurrent meningiomas after surgery and radiation therapy.
Unicorns and cowboys in digital health: the importance of public perception
Authors: None The Lancet Digital Health
Journal: The Lancet Digital Health (2019)

2018 brought unprecedented success for the health-care and biotech industry, with 16 companies reaching the US$1 billion valuation mark needed for them to earn the title of unicorn—an indication of rarity and worth. However, despite the growing number of health-care unicorns in 2019, including Babylon Health, Doctolib, and CMR Surgical, there is still little evidence that valuation is the best way to define interventions and services that are making a difference to patients' health and wellbeing.
Aging Research on the International Agenda
Authors: N. Swan
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies on Staphylococcal Infections
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Who is a medical student? What is a medical school? When is a physician?
Journal: JAMA (1970)

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Histochemie der Haut.
Journal: JAMA (1928)

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Medical-Care Expenditures Attributable to Cigarette Smoking During Pregnancy—United States, 1995
Journal: JAMA (1997)

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VAGINITIS AND THE PILL
Journal: JAMA (1966)

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Orthopedic History
Journal: JAMA (2002)

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THE IRISH PHYSICIAN AS A POET
Journal: JAMA (1963)

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THE SARATOGA SPRINGS MEETING
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II study of induction chemotherapy (ICT) with gemcitabine (G) and vinorelbine (V) followed by concurrent chemoradiation therapy (CCRT) with oral etoposide (E) and cisplatin (P) for inoperable stage IIIA/B non-small cell lung cancer (NSCLC)
Authors: D. H. Lee, J. Y. Han, K. H. Cho, J. H. Chun, H. G. Lee, J. J. Lee, H. R. Pyo, S. J. Yoon, J. I. Zo, J. S. Lee
Journal: Journal of Clinical Oncology (2004)

7255 Background: CCRT with EP was feasible and showed favorable survival outcome (Lee JS et al, Int J Radiat Oncol Biol Phys. 1998). We combined ICT with GV and CCRT with EP to reduce systemic failures. We used different regimens for ICT and CCRT, hoping to reduce toxicity and to kill resistant clones. Methods: Chemo-naïve pts with inoperable clinical stage III NSCLC without pleural effusion, KPS 70–100, and weight loss ≤ 5% were enrolled. Before CCRT, 3 cycles of ICT with G 1000 mg/m2 and V 30 mg/m2 on D1 and 8 were given every 3 weeks. Once-daily thoracic RT (1.8 Gy/day, 5 days/week, total 63 Gy over 7 weeks) was given concurrently with E 100mg on D1–5, 8–12, 29–33, 36–40 plus P 50 mg/m2 on D1, 8, 29, 36. Results: From 4/2002 to 11/2003, 42 pts were enrolled; median age: 59 (43–72) years; M/F: 37/5; histology: 26 squamous ca, 12 adenoca, 4 others; stage: 14 IIIA, 28 IIIB. 34 of 42 pts were evaluated for response and toxicity (5 too early to evaluate). After ICT with GV, there were 15 PR (44%), 11 SD (32%), 8 PD (24%; 4 locoregonal, 4 distant). CCRT was given to 28 of 30 pts who did not have distant failure (2 PR pts declined CCRT). 7 pts who had SD (5) and PD (2) after ICT achieved additional PR, but 6 pts (including 3 PR pts after ICT) progressed after CCRT. Overall response rate was 65% (22/34pts). After a median follow-up of 11.2 months, we observed 21 failures of 34 pts (16 distant, 3 local, 2 treatment related death) with median time to failure of 8.8 months. 1-year survival rate was 73% and median overall survival has not been reached yet. During ICT, toxicity was mild and manageable. But during CCRT, toxicity was significant; 80% G3/4 hematologic toxicity, 24% G3/4 esophagitis, and 30% G3/4 pneumonitis. Conclusions: This regimen showed promising activity and survival data comparable to other studies. But considering toxicity of CCRT, newer agents or treatments to diminish toxicity are needed. Updated response and survival data will be presented. (Supported in part by NCC 0210240; Gemcitabine was provided by Eli Lilly and Co). No significant financial relationships to disclose.
Book Review Digest of Laws and Regulations Relating to the Prevention and Control of Syphilis and Gonorrhea in the Forty-Eight States and the District of Columbia . Compiled under the direction of Bascom Johnson, A.B., LL.B. 8°, cloth, 438 pp. New York: Published and distributed by The American Social Hygiene Association, Incorporated, with the co-operation of The United States Public Health Service, 1940. $5.00.
Journal: New England Journal of Medicine (1941)
NUTRITION AND THE OLDER ADULT
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal