tbuckley/cabot-search huggingface dataset:
An unusual paracetamol overdose
Journal: Journal of the Royal Society of Medicine (2004)

Obesity in Chinese children I do not wish to add fuel to the fire by entering into a discussion on food advertising versus physical inactivity as the culprit for childhood obesity that was prompted by Dr Ashton's editorial (February 2004 JRSM 1 ).I always tell my overweight or obese patients that body fat does not grow on the tree; it has to come from an external source, either overeating or underexertion.The best example comes from China.China used to be known for her slender people; I never saw a fat person in China until very recently. 2Now China is fighting obesity, especially childhood obesity, just like the rest of the world.According to the latest statistics from China, the proportion of obesity among children under the age of 15 increased from 15% in 1982 to 27% today. 3Among the predisposing factors for increasing prevalence of childhood obesity in China, fast food and physical inactivity are the two most important.Because of the efficient advertisements of such fast food giants in the United States as McDonald's and Kentucky Fried Chicken, Chinese children are devouring the American fast food faster than ever. 2,4All of the children in China recognize the image of Ronald McDonald, even though they might not be able to read English. 4hat physical inactivity is the other important risk factor for obesity in Chinese children is illustrated by three observations.First, the effect of television on childhood obesity in China has been documented: each hourly increment of television viewing is associated with a 1-2% increase in the prevalence of obesity in urban China. 5econd, childhood obesity is more prevalent in urban areas than in rural areas, not only because children in rural China are physically more active 6 but also because urban boys consume more fat than rural boys-23-30% versus 16-20%. 7Third, urban children in China are engaged in more homework because they are under pressure to achieve scholastically, whereas rural Chinese children are engaged more in field work because of economic necessity.
L'Exploration fonctionnelle du foie et l'insuffisance hépatique.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion
Authors: Miguel A. Sanjuan, Navin Rao, Kuei-Tai A. Lai, Yin Gu, Siquan Sun, Anja Fuchs, Wai-Ping Fung-Leung, Marco Colonna, Lars Karlsson
Journal: The Journal of Experimental Medicine (2006)
Peer victimisation during adolescence and its impact on depression in early adulthood: prospective cohort study in the United Kingdom
Authors: Lucy Bowes, Carol Joinson, Dieter Wolke, Glyn Lewis
Journal: British Journal of Sports Medicine (2016)

To investigate the strength of the association between victimisation by peers at age 13 years and depression at 18 years.Longitudinal observational study.Avon Longitudinal Study of Parents and Children, a UK community based birth cohort.6719 participants who reported on peer victimisation at age 13 years.Depression defined according to international classification of diseases, 10th revision (ICD-10) criteria, assessed using the clinical interview schedule-revised during clinic assessments with participants when they were aged 18 years. 3898 participants had data on both victimisation by peers at age 13 years and depression at age 18 years.Of the 683 participants who reported frequent victimisation at age 13 years, 101 (14.8%) were depressed according to ICD-10 criteria at 18 years; of the 1446 participants reporting some victimisation at age 13 years, 103 (7.1%) were depressed at age 18 years; and of the 1769 participants reporting no victimisation at age 13 years, 98 (5.5%) were depressed at age 18 years. Compared with children who were not victimised those who were frequently victimised by peers had over a twofold increase in odds of depression (odds ratio 2.96, 95% confidence interval 2.21 to 3.97, P<0.001). This association was slightly reduced when adjusting for confounders (2.32, 1.49 to 3.63, P<0.001). The population attributable fraction suggested that 29.2% (95% confidence interval 10.9% to 43.7%) of depression at age 18 years could be explained by peer victimisation if this were a causal relation.When using observational data it is impossible to be certain that associations are causal. However, our results are consistent with the hypothesis that victimisation by peers in adolescence is associated with an increase in the risk of developing depression as an adult.
Stop the continuing education bandwagon. I want to get off to take a side trip
Authors: D. M. Baer
Journal: JAMA (1977)

AS I VIEW continuing education for physicians, nurses, and other medical personnel, it appears that a formalized structure is being developed that is constraining rather than stimulating the pursuit of knowledge. A system of recognition, certification, and accreditation is being established that stresses traditionally oriented organized programs and fails to recognize the needs, objectives, initiative, and responsibility of the individual in planning and seeking his own continuing education. Programs are generally oriented toward the needs of the urban hospital-affiliated person who practices within a traditional setting and who is not exploring new frontiers in the health care system. Programs of continuing education directed toward nurses and other nonphysicians appear to be oriented toward the needs of the employer and the interests of the regulatory agencies rather than the interests of the person seeking the education. Recognition and accreditation of education, especially for nonphysicians, appear to ignore the motivation and responsibility
TYPHOID FEVER IN CITIES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intra-Arterial Pressure Studies on Patients with Arterial Insufficiency of the Lower Extremities
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 61: ECM scaffolds to elucidate the role of Col11a1 in head and neck cancer progression
Authors: Sufi M. Thomas, Jonathan Enders, Greta Isai, Andras Czirok
Journal: Cancer Research (2019)

Abstract Cancer progression is linked to physical properties, cellular and biochemical composition of the tissue environment including the extracellular matrix (ECM). The ECM not only provides signaling cues by presenting ligands, but also plays a key role in mechano-sensing: modulation of biochemical pathways by physical forces. Collagens are one of the most abundant components of the ECM. We previously reported that head and neck squamous cell carcinoma (HNSCC), which is the 6th most common cause of cancer mortality worldwide with &amp;lt; 40% 5-year survival rates, express higher levels of collagen 11a1 (Col11a1) than normal adjacent mucosa. Col11a1 is a minor fibrillar collagen whose main physiologic role is to regulate the diameter of major collagen fibrils in the cartilage. Although reported that Col11a1 facilitates HNSCC proliferation and invasion, not much is known about its role in the tumor microenvironment. We tested the hypothesis that Col11a1-cancer interdependence facilitates tumor adhesion and metastatic colonization. We developed ECM substrates from cell lines and HNSCC tumor tissue that were characterized by scanning electron microscopy and immunofluorescence microscopy. Electrospun meshes with ECM substrates were developed and used to assess HNSCC adhesion, proliferation and motility. We used a 3D multi-cell type spheroid culture model called the primitive-lung-in-a-dish (PLiD) to demonstrate that Col11a1 siRNA targeting attenuates HNSCC colonization in the lung. Further, using homogenized and lyophilized decellularized ECM from mouse lungs, we demonstrate that Col11a1 regulates motility of HNSCC. Overall, we have used several models to elucidate the role of Col11a1 in HNSCC adhesion and metastatic colonization. Citation Format: Sufi M. Thomas, Jonathan Enders, Greta Isai, Andras Czirok. ECM scaffolds to elucidate the role of Col11a1 in head and neck cancer progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 61.
Truxima Gets High Marks from Physicians
Journal: Cancer Discovery (2018)

Doctors are convinced that Truxima, the first rituximab biosimilar approved by the FDA, is as effective as rituximab; European experience with the biosimilar over the last 2 years has also revealed no problems with unexpected side effects. However, cost will be a factor in determining whether doctors in the United States prescribe Truxima instead of rituximab.
Pharmacokinetics in clinical practice. 2. Applications
Authors: M. Gibaldi
Journal: JAMA (1976)

The pharmacokinetic concepts introduced and defined in a preceding article are now applied to the management of drug therapy for the individual patient. The factors that affect the time course of drug concentrations in plasma produced by repetitive administration include the dosing rate, total clearance, biologic half-life, and systemic availability of the drug. A clinical pharmacokinetics service can monitor drug concentrations in biologic fluids, design individualized drug-dosing regimens, and carry out pharmacokinetic diagnostic work-ups to help determine the reasons for a patient's unusual response to drug therapy. (<i>JAMA</i>235:1987-1992, 1976)
DIAGNOSTIC USE OF β-ADRENERGIC BLOCKADE
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preventive Medicine
Authors: Miriam D. Manning
Journal: New England Journal of Medicine (1949)

SEVENTEEN centuries ago Aretaeus1 of Cappadocia made the first mention in formal medical literature of the practice of isolation as a means of controlling disease, and until recently the control of communicable disease has been the prevailing and only concept of preventive medicine. If one studies the history of preventive medicine the reason for this concept is obvious, but if the new accomplishments in the field are to be placed in their proper perspective, the first realization must be that not the least of the recent advances has been recognition of the profound proportions and province of preventive medicine.Simmons, . . .
Letter: A medicolegal encounter in Maryland
Authors: Jonathan M. Williams
Journal: JAMA (1975)

<h3>To the Editor.—</h3> A matter of great importance to the Medical and Legal community in Maryland came about during the first week of December 1974. The precedent it so nearly established raises great fear in my mind as to how state power and arrogance can infringe on the rights of members of its citizenry. The story started Oct 15, when a baby girl was born in Holy Cross Hospital, in Silver Spring, Md. The child was the second child to a young, intelligent, professional couple, but was born with severe birth defects—a widely opened and uncovered meningomyelocele or rachischisis in the dorsal-lumbar region, severe clubbing of the feet and deformity of the long bones of both lower extremities, genu recurvatum, no movement or sensation below the waist, and no bladder or bowel control. In addition to this, there was evidence of a beginning hydrocephalus. The pediatrician called in for consultation
Commentaire de travail de S. Amornyotin et al., pp. 581
Journal: Endoscopy (2009)

See also: Topical viscous lidocaine solution versus lidocaine spray for pharyngeal anesthesia in unsedated esophagogastroduodenoscopyEndoscopy 2009; 41(07): 581-586DOI: 10.1055/s-0029-1214865
Control of Cellular Influx in Lung and Its Role in Pulmonary Toxicology
Authors: William S. Lynn
Journal: Environmental Health Perspectives (1984)

The pulmonary influx of cytotoxic inflammatory cells, normally, in response to external toxins, is now thought to be etiologic in many of the disease syndromes of man, such as bronchitis and emphysema. Many types of effector inflammatory cells are involved, e.g., eosinophils, neutrophils, T-lymphocytes, monocytes. The diseases are characterized either by tissue destruction or by tissue hyperplasia. Agents which initiate the influx and cytotoxic secretions by these cells are legion and in general are not cell-specific. They include agents, such as phorbol esters, formyl peptides-complement fragments, elastin fragments, fatty acids (leukotrienes) as well as many uncharacterized excretions of inflammatory cells themselves, which react with specific receptors on the inflammatory cells, and secreted proteins such as fibronectin. Other agents, such as linoleic acid, digitonin and hydroxy fatty acids which are not bound by specific receptors also activate motility of inflammatory cells. The precise role of the above multiple cytotoxins in specific cellular fluxes in most pulmonary disease remains undefined. Similarly, the mechanism of cytotoxicity used by specific invading cells in specific pulmonary syndromes remains unclear. In general, macrophages are thought to destroy using specific proteases, neutrophils use oxidant radicals and proteases and eosinophils use basic surface active peptides. T-cells kill by unknown mechanisms. However, in specific clinical syndromes, it is usually not clear which cell is the cytotoxic culprit, nor is the mechanism of destruction usually known.
TINEA UNGUIUM.
Authors: H. C. SEMON
Journal: British Journal of Dermatology (1922)

Journal Article TINEA UNGUIUM. Get access H. C. SEMON, M.D., M.R.C.P. H. C. SEMON, M.D., M.R.C.P. Physician to the Skin and V.D. Departments, Royal Northern Hospital, and Dermatologist to the Hampstead General Hospital, and to the Ministry of Pensions Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 34, Issue 12, 1 December 1922, Pages 397–400, https://doi.org/10.1111/j.1365-2133.1922.tb11351.x Published: 01 December 1922
CONCERNING HEREDITY AND TUBERCULOSIS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiologic stimuli simulating ischemic heart disease
Authors: H. J. Marriott
Journal: JAMA (1967)

After the unrecognized normal variant,<sup>1</sup>the next most important coronary mimic is the physiologic stimulus that upsets the electrocardiogram. Changes so produced are obviously not indicative of heart disease and usually revert to normal soon after the stimulus is removed. Simplest of these are the changes with posture: for example, the normally upright T<sub>2</sub>wave may become inverted and the normal P-R interval may become prolonged when the subject stands. Since ECGs are, in practice, seldom recorded with the patient in any but the recumbent position, this is an unimportant source of confusion. Exercise can produce widespread inversion of T waves in susceptible normal persons and it is therefore important never to regard an exercise test as positive because of T-wave changes alone. The primitive, self-preservative act of eating may prolong A-V conduction and may flatten or invert the T waves. This change is apparently related to the carbohydrate
ADHD Care
Authors: Bridget M. Kuehn
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case-related use of the medical literature. Clinical librarian services for improving patient care
Authors: G. Scura
Journal: JAMA (1981)

Clinical librarian services provide highly specific, case-related medical literature searches in a manner that permits the information obtained to influence ongoing case management. We have measured the impact of such services on actual case management and on diagnostic thinking in a random sample of 50 searches over five months provided to house officers on medical and pediatric services of a university hospital. Patient management was affected in 20% of cases, and diagnostic thinking was influenced in an even higher percentage of instances. In comparison with information generated by other ancillary services such as clinical laboratories, clinical librarian services appear to be highly effective at an acceptable cost. Since the information generated by such searches may often result in further cost savings to patients, the potential overall efficiency of such services may be great. (<i>JAMA</i>1981;245:50-52)