tbuckley/cabot-search huggingface dataset:
AN EXPLANATION FOR THE INFLUENCE OF AGE ON THE OCCURRENCE OF CANCER
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Vivo Mutations in Human Blood Cells: Biomarkers for Molecular Epidemiology
Authors: Richard J. Albertini, Janice A. Nicklas, James C. Fuscoe, Thomas R. Skopek, Richard F. Branda, J. Patrick O'Neill
Journal: Environmental Health Perspectives (1993)

Mutations arising in vivo in recorder genes of human blood cells provide biomarkers for molecular epidemiology by serving as surrogates for cancer-causing genetic changes. Current markers include mutations of the glycophorin-A (GPA) or hemoglobin (Hb) genes, measured in red blood cells, or mutations of the hypoxanthine-guanine phosphoribosyltransferase (hprt) or HLA genes, measured in T-lymphocytes. Mean mutant frequencies (variant frequencies) for normal young adults are approximately: Hb (4 x 10(-8)) < hprt (5 x 10(-6)) = GPA (10 x 10(-6)) < HLA (30 x 10(-6)). Mutagen-exposed individuals show decided elevations. Molecular mutational spectra are also being defined. For the hprt marker system, about 15% of background mutations are gross structural alterations of the hprt gene (e.g., deletions); the remainder are point mutations (e.g., base substitutions or frameshifts). Ionizing radiations result in dose-related increases in total gene deletions. Large deletions may encompass several megabases as shown by co-deletions of linked markers. Possible hprt spectra for defining radiation and chemical exposures are being sought. In addition to their responsiveness to environmental mutagens/carcinogens, three additional findings suggest that the in vivo recorder mutations are relevant in vivo surrogates for cancer mutations. First, a large fraction of GPA and HLA mutations show exchanges due to homologous recombination, an important mutational event in cancer. Second, hprt mutations arise preferentially in dividing T-cells, which can accumulate additional mutations in the same clone, reminiscent of the multiple hits required in the evolution of malignancy.(ABSTRACT TRUNCATED AT 250 WORDS)
Heart "Sympathin"
Authors: W. RAAB, E. LEPESCHKIN, WILDA GIGEE
Journal: Circulation (1950)

In view of the growing recognition of the pathogenic role of the adrenosympathetic humoral neurotransmitters in the heart muscle as chemical anoxia-producing agents, cardiac "sympathin" was extracted and assayed both colorimetrically and biologically, and some of its chemical and pharmacodynamic properties were studied in detail. It proved to be at least in part identical with nor-epinephrine (arterenol) and to exert effects analogous to those of epinephrine and nor-epinephrine upon blood pressure, heart rate and the electrocardiogram (depression or inversion of the T wave). Its action was intensified by cocaine and counteracted by nitroglycerine.
Global Medicine
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate hepatic ischemia-reperfusion injury by regulating neutrophils polarization and suppressing neutrophil extracellular traps formation
Authors: Tongyu Lu, Jia Yao, Xiaomei Zhang, Liang Chen, Jiebin Zhang, Jun Zheng, Jianye Cai, Yingcai Zhang, Yang Yang
Journal: Journal of Hepatology (2020)
Line Omitted.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Latex gloves with a lower protein content reduce bronchial reactions in subjects with occupational asthma caused by latex.
Authors: O Vandenplas, J P Delwiche, S Depelchin, Y Sibille, R Vande Weyer, L Delaunois
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Latex gloves have been documented as causing rhinitis and asthma. Using inhalation challenges, we evaluated the bronchial response to hypoallergenic gloves in eight health care workers with latex-induced asthma. The subjects were exposed to the powdered latex gloves causing asthma at work and various brands of gloves with a lower protein content, either low-powdered, nonpowdered, or powdered. Exposure to hypoallergenic gloves resulted in the absence (in six subjects) or a significant reduction (in two subjects) of bronchial response. The effects of repeated exposure to hypoallergenic gloves was assessed in two subjects who did not demonstrate changes in peak expiratory flow rates and nonspecific bronchial responsiveness to histamine. This study on a limited number of patients suggests that the use of hypoallergenic gloves could be an effective means of reducing the risk of asthmatic reactions in health care workers with latex-induced asthma when complete avoidance cannot be achieved. The long-term effect of exposure as well as the widespread use of hypoallergenic gloves warrant further investigation on larger cohorts of subjects.
Risky business.
Authors: M Baram
Journal: Environmental Health Perspectives (1996)

In prior studies by high-level commissions, emphasis was given to improving the scientific basis and institutional procedures for risk assessment and risk regulation within existing statutory frameworks. Recommendations have led to slow but steady progress. This study is considerably different. It emphasizes a public health approach for efficient use of resources in a new flexible framework for risk management, reductionist approaches to risk assessment and characterization, increased public involvement, and various methods for managing such public involvement. It provides a mix of aspirations and concepts, procedures, and "shop floor rules" for putting the new system of risk management into practice. Concerns remain, however, that bright lines and other rules are at odds with the report's professed aspirations for meaningful public involvement; that ad hoc institutional arrangements for putting each risk in a situational context may not be an efficient use of public and private resources; that techniques for managing stakeholder involvement will be seen as manipulative and may even increase public mistrust and anxieties about risk; and that reductionism by the regulatory clients of risk assessment could diminish progress in the environmental health sciences. Says Lucier, "The goal of risk assessment should be to prevent environmentally or occupationally mediated diseases or injury. This point is not made sufficiently clear in the commission's report. Nevertheless, the report does an admirable job of attempting to merge science, common sense, public perception, public health, economics, and stakeholder interests into a regulatory policy strategy." He continues, "The merging of these diverse inputs will never be easy and should never be overly prescriptive. The complete integration of all relevant information into the risk assessment and risk management process will require greater reliance on expert judgment to make decisions that are timely, that are based on appropriate peer review, that are consistent with public health priorities, that do not create unnecessary regulatory burdens, and that are understandable by the public." The commission's report provides an alternative vision of risk management that incorporates popular political and social trends. Thorough evaluation of the report's recommendations will, at the very least, focus scrutiny on current risk assessment and risk management practices and perhaps produce better solutions.
Heparanase Influences Expression and Shedding of Syndecan-1, and Its Expression by the Bone Marrow Environment Is a Bad Prognostic Factor in Multiple Myeloma.
Authors: Karene Mahtouk, Dirk Hose, Thierry Reme, Michael Hundemer, Michel Jourdan, Eric Jourdan, Veronique Pantesco, Marion Baudard, John De Vos, Marion Larroque, Thomas Moehler, Jean-Francois Rossi, Hartmut Goldschmidt, Bernard Klein
Journal: Blood (2006)
Endoscopy welcomes EIO
Journal: Endoscopy (2014)

On December 19, 2013, the first online issue of the new Open Access journal Endoscopy International Open was released. A newsletter sent out the same day announced the birth of the new journal, which was received enthusiastically and with great interest within the community: up to now, the newsletter has been opened almost 6.000 times and the rate of visitors on our website has increased by 125.24 %, with “Endoscopic submucosal dissection for nonampullary large superficial adenocarcinoma/adenoma of the duodenum: feasibility and long-term outcomes” from Shu Hoteya et al. from Japan being the most viewed article of the month.
Toxic Shock Syndrome
Authors: Kristine L. MacDonald
Journal: JAMA (1987)

Nine cases of severe hypotension or death compatible with toxic shock syndrome (TSS) as a complication of influenza and influenzalike illness were identified in Minnesota with onsets between Jan 2,1986, and Feb 23,1986, in which five of the patients died. During this time, an influenza outbreak was occurring in the state. Cultures of respiratory secretions were performed in eight patients;<i>Staphylococcus aureus</i>was isolated from all of them. Seven<i>S aureus</i>isolates were available for determination of exotoxin production; five isolates produced toxic shock syndrome toxin-1, one produced enterotoxin B, and one produced both. Acute influenza B infection was confirmed in three of four patients for whom throat cultures or acute and convalescent serum samples were available. Two patients fulfilled the Centers for Disease Control—confirmed case definition for TSS. Four additional patients fulfilled the CDC criteria for a probable case of TSS, and TSS was a likely diagnosis in the remaining three patients. The initial presentation was suggestive of nonsuppurative tracheitis or viral pneumonia in eight patients. In the remaining patient, the initial clinical presentation was compatible with staphylococcal pneumonia. This report demonstrates that TSS can occur as a complication of influenza and influenzalike illness. (<i>JAMA</i>1987;257:1053-1058)
Highlights
Journal: JAMA (2019)

Readmission rates following hospitalization for heart failure may be related to the quality of care coordination and continuity.Van Spall and colleagues randomized 2494 adults hospitalized for heart failure and found that implementation of a patient-centered transitional care model, compared with usual care, did not improve clinical outcomes. CME jamanetwork.com/learning Overlapping Surgery and Perioperative Outcomes 762A surgeon who begins a procedure before fi nishing a prior procedure may be less available to address surgical complications.In a retrospective cohort study of 66 430 surgical procedures, Sun and colleagues found that overlapping surgery was not associated with diff erences in in-hospital mortality or postoperative complication rates, but was associated with increased surgery length.
Contents
Authors: Monika Fleckenstein, Paul Mitchell, K Freund, Srinivas Sadda, Frank Holz, Christopher Brittain, Erin Henry, Daniela Ferrara, Marguerite Linz, Albert Jun, Sarah Clever, Shari Lawson, Abanti Sanyal, Adrienne Scott, Paul Steptoe, Janet Scott, Matthew Vandy, Simon Harding, Nicholas Beare, Malcolm Semple, Jessica Shantha, Ian Crozier, Brent Hayek, Beau Bruce, John Fankhauser, Steven Yeh, Kunliang Qiu, Mingzhi Zhang, Reply Pazos, Agnieszka Dyrda, Marc Biarnés, Alfonso Antón, Shida Chen, Reply Akagi, Linda Zangwill, Robert Weinreb, Augustin Lecler, Perrine Gillard, Melinda Chang, Federico Velez, Joseph Demer, Laura Bonelli, Peter Quiros, Anthony Arnold, Alfredo Sadun, Stacy Pineles, Christina Weng, M Bowes Hamill, Joseph Morales, Isha Gupta, Optic Nerve, Head Pits, Erin Boese, David Huang, Shandiz Tehrani
Journal: Ophthalmology (2018)
Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial
Authors: Ramon Estruch, Miguel Angel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Gemma Chiva-Blanch, Miquel Fiol, Enrique Gómez-Gracia, Fernando Arós, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Pilar Buil-Cosiales, José V Sorlí, Miguel A Muñoz, Josep Basora-Gallisá, Rosa María Lamuela-Raventós, Mercè Serra-Mir, Emilio Ros
Journal: The Lancet Diabetes & Endocrinology (2019)
Doctor, I want to die. Will you help me?
Authors: T. E. Quill
Journal: JAMA (1993)

IT HAD been 18 months since a 67-year-old retired man whose main joy in life was his two grandchildren was diagnosed with inoperable lung cancer. An arduous course of chemotherapy helped him experience a relatively good year where he was able to remain independent, babysitting regularly for his grandchildren. Recent tests revealed multiple new bony metastases. An additional round of chemotherapy and radiation provided little relief. By summer, pain and fatigue became unrelenting. He was no longer able to tolerate, much less care for, his grandchildren. His wife of 45 years devoted herself to his care and support. Nonetheless, his days felt empty and his nights were dominated by despair about the future. Though he was treated with modern pain control methods, his severe bone pain required daily choices between pain and sedation. Death was becoming less frightening than life itself. See also pp 874 and 875. A particularly severe
Embryo experiments.
Authors: C B Goodhart
Journal: BMJ (1988)

A fellow of Cambridge University explores the implications of the British Department of Health's 1987 white paper on "Human Fertilisation and Embryology: A Framework for Legislation." The paper proposes the creation of a statutory authority to license experiments on human embryos in vitro during the first 14 days after fertilization, after which any surviving embryos would have to be destroyed. Although believers in the sanctity of human life from fertilization of the ovum oppose any experimentation on human embryos, the embryo conceived in vitro must be distinguished from that conceived in vivo by its inability to develop into a baby unless implanted in a uterus. Legislation resulting from the report is likely also to cover experimentation on later fetuses, either destined for abortion or separated from the mother by abortion, and the ethical and legal questions raised by these situations must not be overlooked.
Error in Text and Table Footnote
Authors: Carrie Colla, Valerie Lewis, Lee-Sien Kao, Ba James O'malley, Chiang-Hua Chang, Elliott Fisher, O Kao, O Lewis
Journal: JAMA Internal Medicine (2017)

Arjola Bano, MD, MSc, DSc; Klodian Dhana, MD, PhD; Layal Chaker, MD, MSc; Maryam Kavousi, MD, PhD; M. Arfan Ikram, MD, PhD; Francesco U. S. Mattace-Raso, MD, PhD; Robin P. Peeters, MD, PhD; Oscar H. Franco, MD, PhD
Immune activation alters cellular and humoral responses to yellow fever 17D vaccine
Authors: Enoch Muyanja, Aloysius Ssemaganda, Pearline Ngauv, Rafael Cubas, Helene Perrin, Divya Srinivasan, Glenda Canderan, Benton Lawson, Jakub Kopycinski, Amanda S. Graham, Dawne K. Rowe, Michaela J. Smith, Denis Gaucher, Sharon Isern, Scott Michael, Guido Silvestri, Thomas H. Vanderford, Erika Castro, Giuseppe Pantaleo, Joel Singer, Jill Gillmour, Noah Kiwanuka, Annet Nanvubya, Claudia Schmidt, Josephine Birungi, Josephine Cox, Elias K. Haddad, Pontiano Kaleebu, Patricia Fast, Rafick-Pierre Sekaly, Lydie Trautmann
Journal: Journal of Clinical Investigation (2014)
Be brave
Authors: Sophie Lyons
Journal: BMJ (2018)

Be braveSophie Lyons describes what it's like to be a frightened child patient, and explains why being called "brave" doesn't help Sophie LyonsI was born with several heart conditions.By the age of 10, I'd had around 18 cardiac procedures: three with my chest opened, others by keyhole, others simply diagnostic.All came with general anaesthetics.Throughout my childhood I was called brave and told there was nothing to be scared of.Doctors, nurses, family members-they all said these words to try and comfort me, especially when I told them I was sad or frightened.But the words didn't stop me from feeling scared.They just made me feel it was wrong to cry, to have these feelings, or even to talk about them.
Pimper Pimped
Authors: Terry A. Rustin
Journal: JAMA (1989)

<h3>To the Editor.—</h3> I was most impressed by Dr Brancati's article on the art of "pimping" in the July 7 issue ofThe Journal.<sup>1</sup>His grasp of the subject is superb. He has provided us with a cogent summary of material critical to success in the academic world. He has filled a void left when the most creative among us began to devote our time to obfuscating insurance companies instead of each other. I am grateful for his timely article. However, I find a major omission in Dr Brancati's otherwise excellent article. Regrettably, he has failed to mention one of the more effective techniques of SID (Sudden Intern Disgrace), employed by advanced practitioners of the art in leading medical centers (although perhaps not widely known in Pittsburgh) and termed "the Feint." When a particularly intense intern (or other antagonist) completes an extensive and thorough evaluation of a clinical problem,
Needle biopsy for the diagnosis of malignant glioma
Authors: L. F. Marshall
Journal: JAMA (1974)

When malignant gliomas involve either deep structures or more than one lobe in the dominant hemisphere, radical surgery has little to offer. Yet, because such lesions may mimic treatable conditions, it is usual to insist on a tissue diagnosis. An alternative to major surgery (craniotomy) is needle biopsy. In a series of 60 cases of suspected malignant or inoperable gliomas, the diagnosis was made with the use of needle biopsy in 53 (88%); only seven patients required craniotomy. Needle biopsy through a burr hole has proved safe and reliable and can be done under local anesthesia. (<i>JAMA</i>228:1417-1418, 1974)
DDT RESISTANT BODY LICE
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac complications following tricyclic antidepressant overdose. Issues for monitoring policy
Authors: R. J. Goldberg
Journal: JAMA (1985)

Thousands of people in the United States poison themselves with tricyclic antidepressants each year. While these patients often require cardiac monitoring for potential arrhythmias, clinical practice is highly variable in regard to the hours of monitoring required. Clarification of this issue is important because of the impact on resources. This study retrospectively reviews the monitoring practices and cardiac complications following tricyclic antidepressant overdose in 75 adults. The patients received an average of 61.7 hours of monitoring. The vast majority of electrocardiographic changes, including three cardiac arrests, appeared within the first 24 hours. No patient with a normal level of consciousness and a normal electrocardiogram for 24 hours went on to develop any significant arrhythmia. On the basis of these data and an extensive literature review, we propose that current guidelines for cardiac monitoring following tricyclic antidepressant overdose be reconsidered. (<i>JAMA</i>1985;254:1772-1775)