tbuckley/cabot-search huggingface dataset:
Guest Authorship, Mortality Reporting, and Integrity in Rofecoxib Studies
Authors: Steven Ferris
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor genomic profiling (TGP) in metastatic colorectal cancer (CRC): Bridging the community and the tertiary cancer center through genomic consultation (GC).
Authors: John M. Kaczmar, Karen S. Gustafson, Yu-Ning Wong, Reetu Mukherji, Carl J. Minniti, Vijay Krishna Sandilya, John David Sprandio, Yana Chertock, Caitlin Hart, Michael J. Hall
Journal: Journal of Clinical Oncology (2016)

1531 Background: TGP of cancers is increasingly accessible to oncologists (MDs) and patients (pts). Despite efforts to provide clinical interpretation and decision support within TGP reports, results are complex and their interpretation remains fraught with uncertainty. In an ongoing pilot, we provide community MDs access to a 50-gene next generation sequencing (NGS)-based TGP assay and expert guidance through remote access to genomic tumor board (GTB) resources via telephone-based GC. Our goal is to explore how access to GTB expertise impacts community patterns of care. In parallel, we examine MDs and pts perceptions of TGP with a focus on awareness and expectations. Methods: MDs from 4 community practices participated. Participating MDs and their pts with metastatic unresectable CRC receiving 2nd line or beyond chemotherapy provide informed consent and complete baseline and follow-up surveys. Adequate tumor samples are tested with the Fox Chase 50-gene NGS-based TGP assay. All results are presented at a bi-monthly GTB or are reviewed with the GTB chair. MDs have a ~10 min GC by telephone with the PI to summarize findings and convey GTB recommendations. Results: 9 MDs have enrolled 25 pts and TGP has been completed on 22 samples (3 insufficient for TGP). Pts report diverse ancestry (24% Hispanic or non-White) and SES (28% income < $25K). To date, all completed TGPs have reported > 1 mutation. Of 15 pts who have received TGP results, 2 have sought consultation at a tertiary center for a clinical trial. Pts with higher education were more aware of TGP (p = 0.05). Most (80%) pts felt TGP would improve their MD’s ability to treat their cancer. Male sex and higher education were associated with stronger belief that TGP will improve life expectancy. Conclusions: A partnership with community MDs to provide TGP and GTB expertise through GC is feasible. Pts exhibit high expectations of TGP, despite limited data to support improved outcomes from TGP-guided treatment. Further research into optimizing partnership between community MDs and tertiary centers is valuable to guide treatment and clinical trial participation based on TGP results.
The organ procurement problem: many causes, no easy solutions
Authors: B. Merz
Journal: JAMA (1985)

This year 20,000 people will suffer brain death from trauma. Only 15% of these people will be organ donors. When the rest are buried or cremated, they will take with them approximately 34,000 kidneys, and as many as 17,000 hearts, livers, pancreata, and pairs of lungs. Thus as many as 100,000 transplantable organs will be lost. "These statistics are only a rough estimate, but they're the best we can do without undertaking a very expensive study," says Jeffrey Prottas, PhD, chair of the organ procurement section of the Task Force on Organ Transplantation. They were derived from a literature survey commissioned by the task force, which was formed under the National Transplantation Act of 1984 to evaluate issues generated by the practice of replacing the organs of one person with those of another. And while these figures may be inexact, the task force thinks they are a reasonable illustration
TEA DRINKING.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic factors in patients with advanced renal cell carcinoma.
Authors: P. Pardo, C. Muriel, E. Esteban, M. Izquierdo, A. Astudillo, P. Martinez-Camblor, N. Corral, G. Crespo, J. P. Berros, A. J. Lacave
Journal: Journal of Clinical Oncology (2011)

e15011 Background: A retrospective cohort of 135 patients with advanced RCC treated with biological agents and/or cytokines (CK) was analysed between July 1996 and February 2010. Methods: The expression of several biomarkers by immunohistochemistry and 2 analytical variables were analysed and were correlated with prognosis. Results: 67 patients were treated only with biological agents and 68 with CK (23 received also biological agents). The univariate statistical analysis showed that the enhanced expression of HIF1α correlated with a poor prognosis in patients treated with biological agents (PFS 5,4 vs 13,5 months with low expression p=0,033) including sunitinib (PFS 5,4 vs 13,4 p=0,001) and CK (PFS 3,3 vs 5,7 p=0,003). The overexpression of CAIX was associated to a better prognosis in patients that received biological agents (PFS 18,3 vs 5,2 months with decreased expression p<0,001; OS 32,1 vs 7,8 p<0,001) including sunitinib (PFS 16,8 vs 5,5 p<0,001), sorafenib (PFS 8 vs 3,5 p<0,001) and CK (PFS 6,3 vs 2,7 p=0,003; OS 32,9 vs 5,9 p=0,001). Positive PTEN was related to a good prognosis in patients treated with sunitinib (PFS 15,1 vs 6,5 months with negative PTEN p=0,003) and CK (PFS 7,5 vs 3,8 p=0,037; OS 13,7 vs 7,9 p=0,039). The increased expression of p21 was related to a poor prognosis in patients that received biological agents (PFS 5,9 vs 16,8 months with high expression p=0,024) including sunitinib (PFS 6,2 vs 18,9 p<0,001), sorafenib (PFS 4 vs 9 p=0,013) and CK (PFS 3,9 vs 7,5 p<0,001). Thrombocytosis was related to a poor prognosis in patients treated with biological agents (OS 15,9 vs 26,7 months without thrombocytosis p=0,007) and CK (PFS 2,6 vs 5,1 p=0,017; OS 5,9 vs 14,3 p=0,010). Neutrophilia was related to a poor prognosis in patients that received biological agents (OS 17,6 vs 25,4 months without neutrophilia p=0,063) and CK (PFS 2,6 vs 5,7 p=0,019; OS 5,9 vs 12,8 p=0,035). In the multivariate analysis the overexpression of CAIX was a favourable prognostic factor independent of PFS with HR of 0,107 (p<0,001) and OS with HR of 0,055 (p<0,001). Conclusions: Our experience suggests the utility of de HIF1α, CAIX, PTEN, p21, thrombocytosis and neutrophilia as prognostic factors in patients with advanced RCC. CAIX has shown to be an independent prognostic factor.
The Cunning Man
Authors: Robertson Davies
Journal: Annals of Internal Medicine (1997)

Perspectives15 October 1997The Cunning ManRobertson DaviesRobertson DaviesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-8_Part_1-199710150-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Everybody's speech has a tune, and it is always revealing. For social chat it may be a light schertzando, but when in the consulting-room it turns to themes of lower-back pain, of haemorrhaoids, of gas pains, of frequent getting-up in the night, it will turn to andante lamentoso; in it the attentive physician's ear discerns the cry of the infant, or the toddler who wants mother to kiss it and make it better. Or it may be the sound of deep grievance, of one who has been dealt a rotten hand in the game of life, one who sees unworthy ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntravenous Immunoglobulin Therapy for Streptococcal Toxic Shock Syndrome—A Comparative Observational Study 15 October 1997Volume 127, Issue 8_Part_1Page: 634 ePublished: 15 August 2000 Issue Published: 15 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Acellular pertussis vaccine hailed for infants
Authors: C. Marwick
Journal: JAMA (1995)

CHILDHOOD immunization against diphtheria-tetanus-pertussis using an acellular pertussis vaccine for the first three doses has moved measurably closer. Data from two large field trials, one in Italy and one in Sweden, have now been analyzed, and they show clear evidence of efficacy and fewer side effects compared with the control group that received whole-cell pertussis vaccine. See also p 450. Three of the four vaccines used in the trials showed 84% to 85% efficacy. The fourth was only 58% effective. The randomized, double-blind trials began in 1992 and involved more than 25000 children. <h3>The Swedish Trial</h3> In the Swedish trial, 9630 infants were vaccinated at age 2, 4, and 6 months with one of two types of acellular pertussis vaccine combined with diphtheria and tetanus toxoids, or with diphtheria and tetanus toxoids combined with a whole-cell pertussis vaccine, or with diphtheria-tetanus alone. Efficacy data were obtained and analyzed when the
OVARIAN THERAPY
Authors: William P. GRAVES
Journal: JAMA (1927)

It is a matter of keen disappointment to clinicians that the new knowledge gained by science of the function and properties of the female sex hormone has not led to a more effective therapy. But as Novak<sup>1</sup>well points out, the clinician expects some brilliant specific panacea that will cure every functional disorder to which the complex female pelvic mechanism is heir. There are numerous reasons why ovarian substance, at least in its present therapeutic form, should be comparatively nonpotent. In the first place the incretory power of the ovary in the normal adult woman is directed chiefly to the pelvic organs for purposes of reproduction, and has little to do with the other functions of her general organism. This is shown by the comparatively small harm that is done by the removal of the secretion. The ovary is not an organ of the same vital significance as the
Highlights
Journal: JAMA (2017)

Levothyroxine for Infertile Women With Thyroid Autoimmunity 2190Pregnant women with thyroid autoantibodies are at increased risk of spontaneous miscarriage.In a randomized trial of 600 infertile women with positive antithyroperoxidase antibodies who had in vitro fertilization and embryo transfer, Wang and colleagues found that levothyroxine treatment failed to decrease miscarriages or increase live births. CME jamanetwork.com/
BOOK REVIEWS
Journal: Allergy (1977)

Book reviews in this article: Johansson, S. G. O., Strandberg, K. &amp; Uvnäs, B. (eds.): Molecular and Biological Aspects of the Acute Allergic Reaction. Rother, K. O. &amp; de Weck, A. L. (eds.): Mediators of the Immediate Type Inflammatory Reaction
MARKED SOMNOLENCE OF LONG STANDING AS A SYMPTOM OF SYPHILIS.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preface
Authors: M. J. Stanton
Journal: JNCI Journal of the National Cancer Institute (1965)

Journal Article Preface Get access M. J. Stanton M. J. Stanton Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 35, Issue 1, July 1965, Page III, https://doi.org/10.1093/jnci/35.1.III Published: 01 July 1965
Punched-Out Erosion of Lamina by Spinal Ependymona: Case Report
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
薄皮肤恶性黑色素瘤的诊断对存活率有何影响?
Journal: British Journal of Dermatology (2021)

皮肤恶性黑色素瘤是一种可致死的皮肤癌。大多数国家/地区被诊断为皮肤恶性黑色素瘤的患者人数正在上升。2018 年, 瑞典约有 4000 名患者被诊断患有此疾病。皮肤黑色素瘤致死的风险在很大程度上取决于黑色素瘤的厚度, 病理学家会在切除黑色素瘤后给出该测量结果。致死风险随厚度的增加而加大。大多数被诊断为皮肤黑色素瘤患者的黑色素瘤较薄, 即厚度为 1 毫米或更薄。
Prognostic Value of Serum β2-Microglobulin in Patients with Waldenstrom’s Macroglobulinemia Requiring Treatment.
Authors: Athanasios Anagnostopoulos, Konstantinos Zervas, Evangelos Terpos, Marie Christine Kyrtsonis, Argyris Symeonidis, Dimitra Gika, Konstantinos Bourantas, Athanasios Zomas, Nikolaos Angnostopoulos, Gerasimos Pangalis, Meletios A. Dimopoulos
Journal: Blood (2005)
Autism
Authors: I Rapin
Journal: New England Journal of Medicine (1997)

Few disorders seem more confusing than autism. Common stereotypes — of a severely withdrawn, mute child with ceaselessly repetitive activities and an averted gaze or a freakish-looking, inept, mathematical prodigy — do not accurately reflect the broad spectrum of autism. Far from being emotionally ill but otherwise normal, persons with autism are now considered to have one of a group of developmental disorders of brain function that have such a broad range of behavioral consequences and severity that they are referred to, collectively, as pervasive developmental disorder (often called PDD) in the fourth edition of the Diagnostic and Statistical Manual . . .
Traité de radiodiagnostic: Squelette en général; tète—rachis-bassin—membres.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Comments
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Prevalence and Clinical Impact of Leukopenia Among Arab Population with Iron Deficiency Anemia an Experience from Qatar
Authors: Hussam A Almasri, Ashraf Tawfiq Soliman, Vincenzo Desanctis, Mustafa A Al-Tikrity, Arwa E Alsaud, Rita Wafik Ahmad, Mona M Babikir, Majd M Aldwairi, Mohammad N Kloub, Mahmoud S Eisa, Ruoa Alhashimy, Shaima Ahmed, Mohamed A Yassin
Journal: Blood (2020)
Leukemic Blasts Acting as Host Antigen Presenting Cells Trigger a Combined CD4 and CD8 Allo-Immune Response Directed against Mismatched HLA Class I
Authors: Avital L. Amir, Renate S. Hagedoorn, W.A. Eric Marijt, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Journal: Blood (2008)
Medical News
Authors: Hubert Work
Journal: JAMA (1918)

(Physicians will confer a favor by sending for this department items of news of more or less general interest; such as relate to SOCIETY ACTIVITIES, NEW HOSPITALS, EDUCATION, PUBLIC HEALTH, ETC.) <h3>CALIFORNIA</h3><h3>Baby Health Centers Opened.</h3> —The Children's Aid Committee of San Francisco announces that thirty baby health centers will be opened in the city as soon as possible after the subsidence of the epidemic of influenza. <h3>Los Angeles Unit Leaves for France.</h3> —The Woman's Hospital Unit of Los Angeles, assigned for active work in France, left for New York. The unit is composed of ten women physicians, Drs. Etta G. Gray, Margaret M. Gilliland, Cecilia Reiche, Margaret Isaac Wilson, Maria C. Wells and Eva K. Greene, all of Los Angeles, and four other physicians, ten hospital aids, an ambulance driver and a chauffeur. <h3>San Francisco Physicians Called Before State Board.</h3> —A number of physicians were ordered to appear before
Milk-curd bowel obstruction in the newborn infant
Authors: L. Graivier
Journal: JAMA (1977)

IN 1969, Cook and Rickham<sup>1</sup>first reported a syndrome of neonatal intestinal obstruction due to inspissated milk curds. This new entity had not been seen before in more than 600 cases of bowel obstruction in newborn infants admitted to the Liverpool Neonatal Surgical Center and had not been previously described in the literature. They found that the obstruction occurred primarily in premature infants in whom high-caloric feedings were begun shortly after birth. In all eight cases, the babies were well at birth, passed normal meconium stools, and began receiving feedings of either reconstituted powdered milk or diluted milk-concentrate. Altered stools and then milk stools were passed until low small-bowel obstruction suddenly developed at ages 5 to 14 days. Studies indicated that milk-curd obstruction resulted from a combination of early feeding of high-caloric milk and the decreased ability of the infant to absorb proteins and amino acids. Of interest was
Gonorrheal conjunctivitis
Authors: R. W. Thatcher
Journal: JAMA (1971)

As gonorrhea increases in the United States, there is great danger that gonorrheal conjunctivitis with its serious sequelae will increase in similar proportions. Reports from several authors and personal experience indicate this may be occurring. With the increasing resistance of the gonococcus to penicillin, this drug alone may no longer be adequate therapy for gonorrheal conjunctivitis.