tbuckley/cabot-search huggingface dataset:
THOMAS JOSEPH PETTIGREW (1791-1865) —BIOGRAPHER AND ANTIQUARIAN
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Results of Operation for Varicocele."
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2018)

Previous studies of myo-inositol for preterm infants with respiratory distress found reduced severity, and less frequent retinopathy of prematurity, death, and intraventricular hemorrhage.In this clinical trial of 638 premature infants younger than 28 weeks' gestation, Phelps and colleagues for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network report that treatment with myo-inositol for up to 10 weeks, compared with placebo, did not reduce the risk of type 1 retinopathy of prematurity or death (29% vs 21%, respectively), and suggest that these fi ndings do not support the use of this agent among premature infants.
Active enforcement of cigarette control laws in the prevention of cigarette sales to minors
Authors: L. A. Jason
Journal: JAMA (1991)

<h3>Objective.</h3> —To assess the effect that cigarette legislation would have on reducing merchant sales rates of cigarettes to minors and the affect on adolescent smoking behavior. <h3>Design.</h3> —Observational survey of merchant selling behaviors and adolescent smoking habits before and after passage of legislation. <h3>Setting.</h3> —The setting for the merchant survey was Woodridge, Ill (population 25 200), a suburban community of Chicago. The surveys were distributed to adolescents in the local junior high school. <h3>Participants.</h3> —Convenience sample of both merchants and adolescent students. <h3>Intervention.</h3> —Passage of community antismoking legislation. <h3>Main Outcome Measures.</h3> —Percentage of stores selling cigarettes to minors in Woodridge and percentage of students who had experimented with cigarettes or were regular smokers. <h3>Results.</h3> —Merchant sales rates in Woodridge decreased from a baseline of 70% before legislation to less than 5% in 1.5 years of compliance checking after legislation. Student surveys showed that the rates of cigarette experimentation and regular use of cigarettes by adolescents were reduced by over 50%. <h3>Conclusion.</h3> —Cigarette control laws can be effective in significantly reducing the rate of cigarettes sold by merchants and rates of cigarette use by adolescents. Key elements of successful legislation implementation are consistent compliance checking and heightened community awareness of the problems and prevalence of adolescent smoking. (<i>JAMA</i>. 1991;266:3159-3161)
11. Older Adults:<i>Standards of Medical Care in Diabetes—2018</i>
Journal: Diabetes Care (2017)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Emotional Stresses of Patient-Physician Encounters
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2017)

Scalp Cooling Device for Chemotherapy-Induced Alopecia 596Chemotherapy can induce alopecia.Nangia and colleagues report the results of a randomized clinical trial of 182 women with breast cancer undergoing chemotherapy, in which patients who used a scalp cooling device were less likely to have hair loss than patients who did not use the device.In an Editorial on this trial and a prospective cohort study on the same topic in this issue, Hershman discusses the distress of chemotherapy-induced alopecia and the costs of providing cooling devices to patients.
Bone Scanning
Authors: Robert E. O'Mara
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The recent article on the limitations of bone scanning in clinical oncology by Loeffler et al (234:1228, 1975) deserves comment. The authors illustrate three cases in which, they contend, the roentgenograms showed findings that were not apparent on the radionuclide studies. In case 1, a roentgenographically confirmed lytic lesion in the left ilium is described as being associated with normal scan findings in the same location. The area in question has<i>less</i>than the normal amount of uptake on scan—a distinct abnormality. Such "photon-deficient" lesions have been well described.<sup>1</sup>The suggested mechanism is a compromised blood supply to the area. The asymmetry between the right and left ilium is seen clearly on the scan. No experienced observer would miss the lesion although it is true that on the basis of the scan finding, the side of the lesion could not be determined. In case 2, the
SCIDOT-01. NANOPARTICLE DELIVERY OF MIRNAS TO INHIBIT GBM STEM CELLS
Authors: Hernando Lopez
Journal: Neuro-Oncology (2019)

Abstract Options for treating high-grade brain tumors remain limited. Recent developments in nanomedicine provide new and exciting opportunities to treat and manage brain tumors. Epigenetic modifications, involving deregulation of non-coding RNAs, in particular miRNAs, are emerging as critical determinants of gene expression and essential drivers of neoplastic phenotypes. Cationic polymers are a class of biomaterials with great promise for targeted molecular therapeutics. We combined this cutting-edge technology with our newly discovered stem cell inhibiting miRNAs to develop nano/miR to treat gliomas. We show these nano/miR distribute throughout an established tumor in vivo, and more importantly, delivering these tumor-suppressing miRNAs using PBAE polymers inhibits the growth of established GBM tumor in mouse models. Our findings demonstrate that identifying and validating stem cell-inhibitory in combination with current advances in nanomedicine will undoubtedly impact the development of novel therapies for targeting the CSC population and treating GBM.
Autosomal Trisomies and Partial Trisomy Syndromes (with Presentation of Two Cases of Partial Trisomy for E Group of Chromosomes)
Authors: W A Zaleski
Journal: JAMA (1963)

The establishing of 46 chromosomes as the normal complement in man and the report of the sex chromatin bodies in buccal smears were followed by reports of trisomies and other abnormal patterns of the X and Y chromosomes in Klinefelter's and Turner's syndromes. Abnormal autosomal complements were described in mongolism, in the E-trisomy syndrome, the D-trisomy syndrome, in the Sturge-Weber syndrome, Waldenstrom's macroglobulinemia, benign congenital hypotonia, atrial septal defect and in the schizoid personality. Certain of these conditions, as well as the "oral-facial-digital" syndrome, were also found to exist as partial trisomies. The mechanism of a trisomy is one of non-disjunction and of partial trisomy translocation or insertion. Two cases of the partial trisomy in the E group are described; these are of especial interest because of the familial incidence, longer survival and male sex occurrence, features which are rarely seen in the full E-trisomy syndrome.
Infectious Disease Politics
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosing Ehrlichiosis
Authors: Sam R. Telford
Journal: Annals of Internal Medicine (1996)

Letters1 May 1996Diagnosing EhrlichiosisSam R. Telford III, DSc and Jacqueline E. Dawson, MSSam R. Telford III, DScHarvard School of Public Health; Boston, MA 02115Centers for Disease Control and Prevention; Atlanta, GA 30333Search for more papers by this author and Jacqueline E. Dawson, MSHarvard School of Public Health; Boston, MA 02115Centers for Disease Control and Prevention; Atlanta, GA 30333Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-9-199605010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Stith's case descriptions do not allow us to determine whether these infections were examples of human granulocytic ehrlichiosis caused by an Ehrlichia species related to E. phagocytophila or E. equi or examples of human ehrlichiosis caused by E. chaffeensis. Although physicians do not need to distinguish between these infections for case management, assignment of a specific identity to the etiologic agent is useful for epidemiologic purposes.Human ehrlichiosis is primarily a presumptive clinical diagnosis, and treatment should be promptly initiated when infection is suspected. Definitive diagnosis is difficult in a physician's office or hospital laboratory. Examination of ...References1. Telford SR 3d, Lepore TJ, Snow P, Warner CK, Dawson JE. Human granulocytic ehrlichiosis in Massachusetts. Ann Intern Med. 1995; 123:277-9. Google Scholar2. Telford SR 3d, Spielman A. Babesiosis of humans. In: Collier L, ed. Topley and Wilson's Microbiology and Microbial Infections. 9th ed. London: Edward Arnold; [In press]. Google Scholar3. Rich SM, Caporale DA, Telford SR III, Kocher TD, Hartl DL, Spielman A. Distribution of the Ixodes ricinus-like ticks of eastern North America. Proc Natl Acad Sci U S A. 1995; 92:6284-8. Google Scholar4. Ewing SA, Dawson JE, Kocan AA, Barker RW, Warner CK, Panciera RJ, et al. Experimental transmission of Ehrlichia chaffeensis (Rickettsiales:Ehrlichieae) among white-tailed deer by Amblyomma americanum (Acari:Ixodidae). J Med Entomol. 1995; 32:368-74. Google Scholar Author, Article, and Disclosure InformationAffiliations: Harvard School of Public Health; Boston, MA 02115Centers for Disease Control and Prevention; Atlanta, GA 30333 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySerological responses to Ehrlichia equi, Ehrlichia chaffeensis, and Borrelia burgdorferi in patients from New York State 1 May 1996Volume 124, Issue 9Page: 854-855KeywordsAntigensBloodEhrlichiosisInoculationLiverMotivationPolymerase chain reactionPrevention, policy, and public healthResearch laboratoriesZoonoses Issue Published: 1 May 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 159: Protective Effect of Metallothionein in Ischemic Hindlimb against Oxidative Stress Induced by Benzo[ <i>a</i> ]pyrene
Authors: Sahoko Ichihara, Gaku Ichihara, Toyoaki Murohara, Yoshiji Yamada
Journal: Circulation (2007)

Background: A wide range of biological responses to and toxic effects of exogenous compounds, such as polycyclic and halogenated aromatic hydrocarbons and dioxins, is mediated by the aryl hydrocarbon receptor (AHR). Given that smoking is an important risk factor for ischemic heart disease and peripheral vascular disease, we hypothesized that benzo-[ a ]pyrene (B[a]P), a prototype carcinogen of tobacco smoke, might impair angiogenesis and AHR might play an important role in the regulation of angiogenesis after exposure to B[a]P. The present study investigated this hypothesis in a surgical model of ischemia. Methods and Results: Ischemia was produced by femoral artery ligature in the AHR gene-deficient (AHR −/ − ) and wild type (WT) mice. B[a]P was administered by oral gavage in corn oil (10 ml/kg) at 125 mg/kg once per week beginning at 12 weeks of age (each group; n = 8). Laser Doppler perfusion analyses showed that the ischemic/nonischemic blood flow ratio of WT mice exposed to B[a]P was significantly reduced compared with that of control WT mice (0.67 ± 0.03 vs. 0.78 ± 0.02, P &lt; 0.05) at 3 weeks after surgery. Furthermore, the blood flow ratio was significantly greater in AHR −/ − mice exposed to B[a]P than in WT mice exposed to B[a]P (P &lt; 0.05). At 3 days after ligature, the abundance of cytochrome P450 1A1 mRNA, determined by quantitative RT-PCR analysis, was markedly greater in both ischemic and nonischemic hindlimbs of WT mice exposed to B[a]P than in those of AHR −/ − mice expose to B[a]P. The abundance of metallothionein I and II mRNA was significantly greater in the ischemic hindlimb than in the nonischemic hindlimb among all groups and was, moreover, significantly greater in the ischemic hindlimb of WT mice exposed to B[a]P than in that of AHR −/ − mice expose to B[a]P. Conclusions: The results show that the deletion of AHR gene reduced the adverse effects of exposure to B[a]P on angiogenesis. Our results also suggest that hypoxia in ischemia tissues activates the expression of metallothionein I and II, which may have protective effects against B[a]P-induced oxidative stress responses.
MORTALITY CLASSIFIED FROM A NEW STANDPOINT
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Baseline features of hepatitis C patients associated to prescription of pangenotypic antiviral treatments: results from the real-world Spanish Hepa-C registry
Authors: Juan Turnés, Xavier Forns, Raquel Souto Rodríguez, Juan Manuel Pascasio, Inmaculada Fernández, Francisco Gea, Jose Miguel Rosales Zabal, Xavier Torras, Rosa Morillas, Moises Diago, Jose A. Carrión, Francisco Andrés Pérez Hernández, Manuel Hernandez-Guerra, Manuel Delgado, Jose María Moreno Planas, José Luis Calleja Panero, Martín Prieto, Esther Badia-Aranda, Blanca Figueruela, Beatriz de Cuenca Morón, Vanesa Bernal Monterde, Carme Baliellas, Javier Crespo, Lucia Bonet, José Juan Moreno, Fernando Menéndez, Pau Bellot, Isabel Carmona, Jesús González Santiago, Miguel Fernandez-Bermejo, Maria Buti, Francisco Javier Garcia-Samaniego Rey, Javier Salmerón, Conrado Fernández-Rodríguez, Juan De la Vega, Desamparados Escudero-García, Juan Arenas, Ma Dolores Anton Conejero, Santiago Pérez Cachafeiro
Journal: Journal of Hepatology (2020)
Improving the prediction of colon cancer survival after curative resection.
Authors: Aliyah Pabani, Winson Y. Cheung, Matthew Mazurek, Jennifer L. Spratlin, Julie A. Price Hiller, Leah Jean Standeven, Karen E. Mulder, Sunita Ghosh, Maria Yi Ho
Journal: Journal of Clinical Oncology (2015)

e14587 Background: Cancer staging systems convey valuable prognostic information to both clinicians and patients. Currently, colon cancer is staged according to the American Joint Committee on Cancer (AJCC) TNM classification system. However, survival estimates for patients with the same stage of colon cancer may vary considerably due to other factors including age, sex, grade, and number of lymph nodes sampled. The objectives of this study are to 1) assess the accuracy of the seventh edition of the TNM classification system in predicting survival of patients with primary colon cancer after curative-intent surgery, and 2) evaluate the utility of incorporating additional demographic and tumor variables beyond TNM staging in improving prognostic accuracy. Methods: Patients with curative-intent resection of a first primary adenocarcinoma of the colon at the time of referral to the Cross Cancer Institute between 2004 and 2007 were identified from the Alberta Cancer Registry. We constructed three multivariate Cox’s proportional hazard models to explore the effect of supplementing TNM staging with additional demographic and tumor variables in predicting overall survival (OS). Results: 559 consecutive patients with complete chart records were identified. 52 % (n = 290) were male; median age was 74. In the first model based only on T and N elements, N2 disease was correlated with increased mortality. (hazard ratio (HR), 2.546; p < 0.0001) When the number of lymph nodes examined (HR, 0.980; p = 0.034) and number of metastatic lymph nodes detected (HR, 1.094; p < 0.0001) were substituted for the N-staging element, both variables correlated positively and negatively with outcome, respectively. Finally, when tumor grade, sex and age were incorporated into the model, number of examined lymph nodes (HR, 0.980; p = 0.029) and those containing tumor (HR, 1.093; p < 0.0001) remained independent predictors of OS. Conclusions: Incorporating readily available demographic and tumor variables, such as age, sex and number of lymph nodes examined, can enhance the current TNM staging system and improve prognostication in early stage colon cancer.
POSTPOLIOMYELITIS HYPERTENSION
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal