tbuckley/cabot-search huggingface dataset:
Effect of tumor necrosis factor alpha on intrahepatic bile duct epithelial cell of rat liver
Authors: Y Mano
Journal: Hepatology (1996)

Tumor necrosis factor alpha (TNF-alpha), which is primarily produced by macrophages, is a cytokine with various biological activities. Macrophage infiltration often accompanies experimental cholangitis in rats, and chronic cholangitis in humans. The pathophysiologic significance of TNF-alpha in cholangitis is not known. We used cultured, polarized intrahepatic bile duct epithelial cells (IBDECs) from rat liver to determine whether TNF-alpha directly affects the organization of IBDEC monolayers. The addition of recombinant TNF-alpha (rTNF-alpha) to culture media at concentrations from 10 to 200 U/mL lacked cytotoxicity to the IBDECs as judged by trypan blue exclusion and lactate dehydrogenase (LDH) release. rTNF-alpha transiently reduced transepithelial electrical resistance in a dose-dependent manner. During this decrease in resistance, the cellular tight junctions became leaky, allowing horseradish peroxidase (HRP) penetration. rTNF-alpha, at concentrations up to 200 U/mL, did not detach IBDECs from Matrigel, an artificial basement membrane. Electron microscopy and immunohistochemistry for F-actin showed a well-preserved cell structure and organization of IBDECs. Results suggest that TNF-alpha is nontoxic to IBDECs, and that it increases the permeability of tight junctions. TNF-alpha may thus disturb the barrier function of the bile duct.
Correction
Journal: BMJ (1958)

ANY QUESTIONS?Ethyl Chloride, Nitrous Oxide, and Oxygen Mixture Q.-I give a number of dental anaesthetics, chiefly to children, using a McKesson apparatus with vinyl ether in addition to nitrous oxide and oxygen for prolonged anaes- ihesia.I would prefer, however, to give ethyl chloride in Authors desiring REPRINTS should communicate with the Publishing
Epstein-Barr virus and persistent graft dysfunction after liver transplantation
Authors: A Telenti
Journal: Hepatology (1991)

Epstein-Barr virus infection has been associated with a broad spectrum of clinical manifestations, depending on the immune status of the host. In this report, we describe two liver transplant patients who received hepatic allografts from donors serologically positive for Epstein-Barr virus and who experienced primary infection with Epstein-Barr virus associated with prolonged liver graft dysfunction. In both patients, Epstein-Barr serologies converted within 3 mo of liver transplantation, and hepatic histological study revealed mononuclear infiltration of the sinusoids evolving to pronounced immunoblastic features suggestive of evolving lymphoma. In both cases, in situ hybridization studies confirmed the presence of Epstein-Barr virus genome in the liver. Furthermore, polymerase chain reaction analysis suggested that high levels of Epstein-Barr virus DNA were present in biopsy specimens obtained during the episode of acute hepatitis that followed Epstein-Barr virus seroconversion. The degree of Epstein-Barr virus DNA estimated by polymerase chain reaction appeared to increase in parallel with the progression of parenchymal lymphocytic infiltrates. In one patient, a biopsy sample from a cervical node also revealed high levels of Epstein-Barr virus DNA estimated using the polymerase chain reaction technique. Furthermore, in these patients, Epstein-Barr virus DNA levels appeared to decrease dramatically after discontinuing azathioprine administration and beginning treatment with acyclovir. These two cases illustrate the dynamics of Epstein-Barr virus immune regulation and confirm chronic hepatic allograft dysfunction related to Epstein-Barr viral infection. (HEPATOLOGY 1991;14:282–286.)
The Dead Zones: Oxygen-Starved Coastal Waters
Authors: Stephanie Joyce
Journal: Environmental Health Perspectives (2000)

After the great Mississippi River flood of 1993, the hypoxic (or low-oxygen) "dead zone" in the Gulf of Mexico more than doubled its size, reaching an all-time high of over 7,700 square miles in July of 1999. Scientists attribute the Gulf of Mexico dead zone largely to nutrient runoff from agriculture in the Mississippi River basin. During the warm months, these nutrients fuel eutrophication, or high organic production, causing large algal blooms. When the algae decay, the result is hypoxia. Reports of such hypoxic events around the world have been increasing since the mid 1960s. Eutrophication and hypoxia have resulted in mortality of bottom-dwelling life in dozens of marine ecosystems and have stressed fisheries worldwide. Some algal blooms can alter the function of coastal ecosystems or, potentially, threaten human health. Anthropogenic nutrient loading from sources such as agriculture, fossil fuel emissions, and climate events is believed to be related to the global increase in frequency, size, and duration of certain algal blooms.
Northeastern Arkansas Society Officers.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General Index to the Journal of the American Medical Association.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STATISTICAL STUDIES IN CANCER
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum to: Withholding and withdrawal of life-sustaining treatments in low-middle-income versus high-income Asian countries and regions
Authors: Jason Phua, Gavin M. Joynt, Masaji Nishimura, Yiyun Deng, Sheila Nainan Myatra, Yiong Huak Chan, Nguyen Gia Binh, Cheng Cheng Tan, Mohammad Omar Faruq, Yaseen M. Arabi, Bambang Wahjuprajitno, Shih-Feng Liu, Seyed Mohammad Reza Hashemian, Waqar Kashif, Dusit Staworn, Jose Emmanuel Palo, Younsuck Koh
Journal: Intensive Care Medicine (2016)
The Services
Journal: BMJ (1929)

was (li5'ciissing thlat day.This bill in Lord Daweonm's opiniion, was a coiisideisable advance, wlhiel wouild liave the support of the' best.th1olighit in tlle mnedical professioni.Techinical kinowledge liad grown.Tle mnedicine of to-day was niot thie medicine
Radiation emergencies and the practicing physician
Authors: W. R. Hendee
Journal: JAMA (1987)

Nuclear power and its risks have long been a contentious issue in this country. Advocates of the technology insist that the hazards are miniscule and that nuclear energy has the potential to provide an almost unlimited supply of electricity with little risk to individuals or the environment. Critics reply that the technology threatens the health of communities and even the survival of the human race. This polarization of viewpoints has prevented meaningful discussions between proponents and opponents. Planning for radiation emergencies is a topic for which there have been only sporadic attempts at dialogue. Some physicians and scientists concerned about their abilities to respond to radiation emergencies claim that their overtures to utility companies for information and discussion have been rebuffed with the statement that an event requiring major medical resources cannot occur. In contrast, representatives of utility companies say they are willing to discuss the need to plan for
EXTH-01. MODELING THE SAFETY OF TOPICAL AGENTS FOR SKIN TOXICITY ASSOCIATED WITH TUMOR TREATING FIELDS THERAPY IN GLIOBLASTOMA
Authors: Mario Lacouture, Hadas Hershkovich, Moshe Giladi, Zeev Bomzon, Eilon Kirson, Uri Weinberg, Yoram Plati
Journal: Neuro-Oncology (2018)

Tumor Treating Fields are low intensity, intermediate frequency, alternating electric fields that are approved for the treatment of patients with glioblastoma (GBM). TTFields are applied continuously using a set of four transducer arrays placed on the skin. The main TTFields-related adverse event is mild-moderate dermatitis occurring under the arrays, which is primarily caused by long-term exposure to irritants and may be exacerbated by local hyperhidrosis and occlusion. Strategies that mitigate skin irritation may improve patients’ quality of life and compliance with TTFields. Four product groups (antiperspirants, moisturizing creams, antibiotics, and skin barriers) have been anecdotally reported to alleviate factors related to TTFields-related skin irritation. Nonetheless, not all of the aforementioned products are compatible with TTFields as some may increase electrical impedance, which may lead to increased temperatures beneath the arrays. This study investigated the effect of applying 40 commercially available skin care products on electrical impedance during TTFields application, using a rat model. In these experiments, 200 kHz TTFields were applied using ceramic disks and hydrogels identical to those used with human arrays. Changes in impedance caused by applying each product on the rat skin were measured using the Optune device and an LCR meter system. The review identified a set of skin care products from all 4 groups that did not lead to a significant change in the impedance. Preliminary tests in the clinical setting with these products were promising in a few patient case studies. These results suggest that local application of TTFields-compatible skin care products could maintain normal electrical resistance of the scalp-array interface, thereby allowing optimal delivery of TTFields to the brain. These products should be prospectively investigated for their potential role in minimizing TTFields–related skin irritation.
Abstract P030: Recruitment and Effectiveness by Cohort in a Case Management Intervention Among American Indians and Alaska Natives with Diabetes
Authors: Katherine Pratte, Luohua Jiang, Janette Beals, Ann Johnson, Ann Bullock, Spero Manson
Journal: Circulation (2017)

Introduction: To determine the optimal strategies for effective large-scale implementation of evidence-based interventions, it is critical to investigate continued effectiveness as an intervention rolls out to large, diverse populations. The purpose of this study is to evaluate whether patient characteristics and intervention effectiveness differ by year of enrollment in a multi-year evidence-based translational intervention. Hypothesis: We hypothesize the patients recruited early may have a higher level of readiness to change their behaviors and achieve more improvements in their intervention outcomes than patients enrolled in later years. Methods: The Special Diabetes Program for Indians Healthy Heart (SDPI-HH) Demonstration Project is an intensive case management intervention designed to reduce cardiovascular disease (CVD) risk among American Indian and Alaska Native patients with diabetes. SDPI-HH participants recruited from 2006 through 2008 were included (n=2,910). Baseline characteristics were compared by year of enrollment. We also evaluated the differences in improvements in CVD risk factors among participants recruited in different years. Results: The baseline characteristics of the three cohorts revealed significant differences in demographics, diabetes duration, health behaviors, level of motivation, and clinical measures. Improvements in 13 clinical and behavioral outcomes differed by enrollment year with the 2006 cohort having the greatest number of statistically significant improvements (Table 1). The 2006 cohort also had the highest rates of participant participation and retention. Conclusions: The SDPI-HH participants recruited later had fewer improvements in CVD risk factors, potentially due to the decline in participant motivation over the three years. Further investigation into ways to modify the intensive case management model to address differences in levels of motivation and participation is warranted to improve the prevention of chronic disease in Indian health.
Refilled Prescriptions.
Authors: None R. F. H.
Journal: JAMA (1894)

Ruston, La., April 11, 1894. <h3>To the Editor:</h3> —Has a druggist the right to refill a formula for a patient without the knowledge or consent of the physician? Has the patient the right to obtain a copy of formula from the druggist without the knowledge or consent of the author? In the event the patient is going to leave the community and take up residence in some distant part, has he the right then to obtain a copy of formula, and has the druggist the right to give it with the knowledge of the prescriber? Very respectfully,
Excess Lung Cancer Risk in a Synthetic Chemicals Plant
Authors: Richard J. Waxweiler, Allan H. Smith, Henry Falk, Herman A. Tyroler
Journal: Environmental Health Perspectives (1981)

A standardized mortality ratio of 1.49 for respiratory system cancer (42 observed deaths versus 28.2 expected, p less than 0.01) was observed among a cohort of 4806 males employed at a synthetic chemicals plant since its startup in 1942. Upon review of pathologic material, the excess was found to be limited to adenocarcinoma and large cell undifferentiated lung cancer. Many of the workers had been exposed to vinyl chloride, as well as to chlorinated solvents, poly(vinyl chloride) (PVC) dust, acrylates and acrylonitrile. To evaluate the association between lung cancer and occupational chemical exposures, detailed work histories for each cohort member were combined with exposure ratings for each of 19 chemicals for each job for each calendar year since 1942. A serially additive expected dose model was then constructed which compared the doses of the chemicals observed for the lung cancer cases to the doses expected based on subcohorts without lung cancer individually matched to the cases. PVC dust appeared to be the most likely etiologic agent (p = 0.037). Time trends of PVC dust exposure indicated a potential latent period of 5-16 years before death.
Regulation of benzodiazepine prescription
Authors: A. A. Levin
Journal: JAMA (1992)

<h3>In Reply.</h3> —All published data, particularly those on controversial issues, should be carefully analyzed and interpreted by the readers. In addition, other investigators should gather data attempting to replicate and verify the hypothesis. Fortunately, both analytical reading and several evaluations of the New York State triplicate prescription regulations for benzodiazepines have been carried out. The authors of the letters published in this issue of<i>JAMA</i>interpreted the results of our study differently than did my colleagues and I. Publication of their views is a legitimate, important aspect of the research process. Several other investigators have examined the New York State benzodiazepine regulations. Reidenberg<sup>1</sup>compared benzodiazepine prescribing in New York and Pennsylvania. His conclusion that the full health consequences of the regulations have not yet been clarified mirrors the opinion my colleagues and I articulated in<i>JAMA</i>. The effects of the regulations have also been examined by Shader et al.
Abstract 19: Design and synthesis of biaryl indolyl benzamides as HDAC1-selective inhibitors via a fragment-based lead generation approach
Authors: Ahmed T. Negmeldin, Mary Kay H. Pflum
Journal: Cancer Research (2019)

Abstract Histone deacetylase (HDAC) proteins are epigenetic regulatory enzymes that deacetylate protein substrates, leading to subsequent changes in cell function. HDAC proteins are implicated in cancers and several HDAC inhibitors have been approved by the FDA as anti-cancer drugs. Unfortunately, most of the FDA-approved drugs non-selectively inhibit most of the HDAC isoforms, which may lead to side effects in the clinic and limit their use on the bench top. Isoform-selective HDAC inhibitors may decrease or eliminate the side effects associated with non-selective inhibitors treatment. In addition, isoform-selective HDAC inhibitors can be used as molecular tools to study HDAC-related cancer biology. In this work, several biaryl indolyl benzamide compounds were designed and synthesized based on a fragment-based lead generation approach as potential HDAC1-selective inhibitors. The design was based on combining two different fragments from known HDAC1/2 and HDAC1/3 selective inhibitors. These fragments can discriminate against both HDAC2 and HDAC3 and possibly impart selectivity towards HDAC1. Docking studies were performed to validate the design of the inhibitors and to understand the binding of different isoform-selective inhibitors to HDAC1, HDAC2, and HDAC3. Potency and isoform selectivity of the new compounds were assessed via in vitro screening with different HDAC isoforms. All analogs showed modest selectivity for HDAC1 over HDAC2. Bnz-3 was identified as the best compound in terms of potency and selectivity. In particular, Bnz-3 displayed roughly 10- to 100-fold higher potency than the other compounds, with an IC50 value of 548 nM with HDAC1. In terms of selectivity, Bnz-3 showed about 10.6-fold selectivity for HDAC1 over HDAC2, with almost no inhibition of either HDAC3 or HDAC6. The new biaryl indolyl benzamide HDAC inhibitors represent potential lead compounds that can help to further develop more selective HDAC1 inhibitors. Citation Format: Ahmed T. Negmeldin, Mary Kay H. Pflum. Design and synthesis of biaryl indolyl benzamides as HDAC1-selective inhibitors via a fragment-based lead generation approach [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 19.
Reply
Authors: L Riedel, I Segal
Journal: Gut (1991)

currently using balloon dilatation as opposed to bougies, in the hope that shearing stress on the fragile mucosa is reduced,2 but repeat dilata- tion after either technique seems to be equally common.Thirdly, we feel that oesophageal replacement should be avoided, owing to the particular problems of surgical and anaesthetic management.3Strictures do not always recur after dilatation and none ofour 258 patients has needed oesophageal surgery.Lastly, it is worth noting that an 'inverse' form of dystrophic EB exists, probably with recessive inheritance, in which oropharyngeal and oesophageal involve- ment may be severe, but skin lesions relatively mild.4The management of such difficult problems requires a multidisciplinary approach, with cooperation between dermatologists, gastroenterologists, ENT surgeons, plastic surgeons, anaesthetists, radiologists, and dietitians.
Failure of Cholesterol-Lowering Drugs to Influence Coronary Mortality: A Double Blind 5-Year Secondary Prevention Study.
Authors: Veterans Administration Drug Lipid Cooperative Study Group
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Failure of Cholesterol-Lowering Drugs to Influence Coronary Mortality: A Double Blind 5-Year Secondary Prevention Study.Veterans Administration Drug Lipid Cooperative Study GroupVeterans Administration Drug Lipid Cooperative Study GroupSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-868_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFive hundred seventy male veterans, average age 51 years, with documented transmural myocardial infarction occurring within a 12-month period, were randomized into groups receiving placebo, estrogen (1.25 mg Premarin® per day), dextrothyroxine (4 mg/day), aluminum nicotinate (Nicalex® 4 g/day), combined estrogen and nicotinate (full dosage of Premarin plus Nicalex), or combined estrogen and dextrothyroxine (full dosage of Premarin plus dextrothyroxine). Follow-up was 5 years; the interval between visits, 2 months. Adherence was carefully monitored. Dietary or smoking modifications were not stressed. Average baseline cholesterol was 241 mg/100 ml. Estrogen had no effect on cholesterol levels. Maximal drop in cholesterol was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 868-868KeywordsCholesterolDrugsEstrogensMortalityMyocardial infarctionNiacin ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...