tbuckley/cabot-search huggingface dataset:
An Abbreviated Index Medicus
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3556: MiR-506 suppresses tumor progression by reprogramming macrophage polarization in pancreatic ductal adenocarcinoma
Authors: Longhao Sun, Qianqian Song, Weijun Tian, Zhixiang Zhang
Journal: Cancer Research (2019)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancy owing to its aggressive nature and tumor-associated macrophages (TAMs) significantly promote disease progression by representing an immunosuppressive phenotype in PDAC. Macrophages could be functionally reprogrammed to opposite phenotype owning to different microenvironment and STAT3 (signal transducer and activator of transcription 3) activation may play an essential role in TAM polarization, directly contributing to local immunosuppression. Our recent study demonstrated that MiR-506 functioned as a tumor suppressor in many cancer types through the regulation of multiple pathways and directly targeted STAT3 in PDAC cells. In this study, we hypothesized that MiR-506 could affect tumor microenvironment and exert a tumor suppressive function in PDAC by reprograming TAM polarization through targeting STAT3 in TAM. Our results provided evidence that MiR-506 downregulation was associated with less immunosuppressive TAMs accumulation and better prognosis in human PDAC. MiR-506 could reduce the infiltration of immunosuppressive TAMs and inhibit the PDAC progression in mouse model. MiR-506 reprogramed macrophage polarization from an immunosuppressive phenotype to immune-activated phenotype through direct targeting the STAT3 axis. Silencing and inhibiting STAT3 recapitulated the effects of MiR-506. These findings expand the known mechanisms of MiR-506-mediated tumor suppression to reprogramming TAM polarization and suggest a strategy for using MiR-506 as an anti-STAT3 approach to PDAC immunotherapy. Citation Format: Longhao Sun, Qianqian Song, Weijun Tian, Zhixiang Zhang. MiR-506 suppresses tumor progression by reprogramming macrophage polarization in pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3556.
LncRNA-H19 as a marker of liver progression from steatosis to hepatocellular carcinoma
Authors: Ángela Rojas, Antonio Gil-Gomez, Patricia de la Cruz-Ojeda, Rocio Munoz Hernandez, Yolanda Sánchez, Rocío Gallego-Durán, M. Carmen Rico, Maria Teresa Ferrer Rios, Raquel Millan, Rocío Montero-Vallejo, Sheila Gato Zambrano, Douglas Maya, Francisco Javier Padillo, Jordi Muntané, Javier Ampuero, Manuel Romero Gomez
Journal: Journal of Hepatology (2020)
Reproductive Assessment by Continuous Breeding: Evolving Study Design and Summaries of Ninety Studies
Authors: Robert E. Chapin, Richard A. Sloane
Journal: Environmental Health Perspectives (1997)

The Reproductive Assessment by Continuous Breeding (RACB) design has been used by the National Toxicology Program for approximately 15 years.This article details the evolutions in the thinking behind the design and the end points used in the identification of hazards to reproduction.Means of nominating chemicals are provided, and both early and current designs are described as well as some proposed changes for the future.This introduction is followed by a text and tabular summary of each study performed to date.We hope that this will not only be an explicit presentation of the findings of this
Clara Barton: Daughter of Destiny
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Routine chest radiography for the evaluation of febrile neutropenic patients after autologous stem cell transplantation
Authors: Vivek Roy, Lubna I. Ali, George B. Selby
Journal: American Journal of Hematology (2000)

Chest radiographs are routinely obtained for diagnostic evaluation of neutropenic febrile patients. We investigated the frequency of chest radiographic abnormalities during febrile episodes after autologous PBSC transplants and assessed the relationship of these abnormalities to past history of pulmonary disease, pre-transplant chest radiographic abnormalities, and pulmonary signs or symptoms at time of fever. We also studied the impact of chest radiographic findings on patient management. Sixty-one consecutive adult autologous PBSC transplant recipients were studied. Fifty-two (85%) developed fever, and 20 (38%) of these showed new chest radiographic abnormalities suggestive of pulmonary infection. Patients with pre-transplant chest radiographic abnormalities were more likely to develop additional abnormalities with fever post-transplant. Pulmonary symptoms or signs had low sensitivity or specificity for predicting radiographic abnormalities. Only 40% of patients with pulmonary symptoms or signs had an abnormal chest radiograph. Twenty-six percent of patients with abnormal chest radiographs had no clinical findings suggestive of pulmonary infection. The identification of chest radiographic abnormality did not change empiric antibiotic treatment in any patient. The role of routine chest radiography for diagnostic evaluation of febrile autologous PBSC transplant patients should be re-evaluated. Am. J. Hematol. 64:170–174, 2000. © 2000 Wiley-Liss, Inc.
Fortnightly review: Acute urinary retention in men: an age old problem
Journal: BMJ (1999)

Reducing cholesterol and blood pressure, as well as smoking cessation, have been shown to be effective strategies for preventing cardiovascular diseases. 13][4] Additional factors may have a role in the pathogenesis of atherosclerosis, and new preventive strategies may be of use.In this article we briefly review the use of antioxidants, the use of angiotensin converting enzyme inhibitors, and homocysteine lowering; other "emerging" cardiovascular risk factors and potential preventive strategies that are under investigation are summarised in table 1.
BUENOS AIRES
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood Anti-Oxidant Parameters At Different Stages of Pneumoconiosis in Coal Workers
Authors: John J. M. Engelen, Paul J. A. Borm, Marc van Sprundel, Luc Leenaerts
Journal: Environmental Health Perspectives (1990)

The pneumoconioses are associated with chronic inflammatory processes during which increased amounts of reactive oxygen species are formed in the lower respiratory tract. To characterize the effect(s) of these processes on the defense system against free radicals, we studied 91 individuals with long-term occupational exposure to coal mine dust. Thirty-one subjects were classified with radiological evidence to be pneumoconiotics, while 58 control miners had no pulmonary disorders. We measured antioxidant parameters in red blood cells, considering the latter to reflect the oxidative stress in the lung. Glutathione levels were significantly decreased (p = 0.04) in red blood cells of miners with coal workers' pneumoconiosis with radiograph classification 0/1 to 2/1, while in miners with classification 3/2 to 3/3, the plasma iron concentrations were significantly decreased (p = 0.04). Moreover, some factors of the anti-oxidant system (superoxide dismutase, catalase, glutathione peroxidase) were correlated in the diseased but not in the control miners. Taken together, all data support the role of the erythrocyte as a circulating anti-oxidant carrier and also that changes in red blood cell anti-oxidant factors reflect the oxidative stress imposed by the pneumoconiotic (inflammatory) processes in the lung.
The Throat and Nose, and Their Diseases.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME ODDITIES IN SUICIDE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Role of the Physician and the Medical Profession in the Prevention of International Torture and in the Treatment of Its Survivors
Authors: American College of Physicians*
Journal: Annals of Internal Medicine (1995)

The prevention of torture and the treatment of survivors are issues that concern an increasing number of physicians in their daily work.Every day, thousands of men, women, and children are subjected to violence and are forced to flee their homelands. There are more than 18 million refugees in the world and hundreds of thousands of persons seeking asylum, many of them in the United States. Physicians are often the first to interview these victims of abuse. Torture has serious and long-lasting health consequences. Thus, physicians can play a key role in documenting and preventing many forms of abuse and in treating survivors. In some areas, physicians may become the targets of arrest because of their work as clinicians or as influential members of their communities. They may also face disturbing ethical dilemmas as they witness torture or its results. As members of the medical profession, physicians have an obligation to their peers around the world. This report reviews the current state of physicians' involvement in the prevention of international torture and in the treatment of its victims.We propose ways in which physicians can become involved by caring for survivors of torture and by providing expert testimony on behalf of victims who seek asylum. We discuss how the medical profession complements the efforts of individual physicians by providing an infrastructure to support and guide their work. Medical organizations can adopt and disseminate ethical principles that specifically address human rights and their violation. They can coordinate letter-writing networks for human rights, organize or sponsor fact-finding missions, and develop continuing medical education courses on topics such as the identification and treatment of victims of torture. We conclude that physicians can make a difference, both as clinicians and as advocates for the health of the public and the protection of human rights. The American College of Physicians will continue to advocate for the rights of persons and communities to live in dignity and peace, free of the fear of unjust imprisonment or torture. *This paper, authored by Anne-Marie Audet, MD, MSc, SM, was developed for the Health and Public Policy Committee by the Human Rights and Medical Practice Subcommittee: Quentin D. Young, MD, Chair; Elias Abrutyn, MD; Carola Eisenberg, MD; Paul Plotz, MD; Herbert J. Rothenberg, MD; and Kim M. Thorburn, MD. Members of the Health and Public Policy Committee for the 1992-1993 term were Clifton R. Cleaveland, MD, Chair; Whitney Addington, MD; Robert A. Berenson, MD; Christine K. Cassel, MD; John M. Eisenberg, MD; Nancy E. Gary, MD; David J. Gullen, MD; Ernest L. Mazzaferri, MD; P. Preston Reynolds, MD, PhD; Cecil O. Samuelson Jr., MD; Gerald E. Thomson, MD; Mack V. Traynor Jr., MD; and Quentin D. Young, MD. This paper was approved by the Board of Regents on 18 July 1993.
In situ Monitoring with Tradescantia around Nuclear Power Plants
Authors: Sadao Ichikawa
Journal: Environmental Health Perspectives (1981)

Highly sensitive mutational responses of the stamen-hair system of some Tradescantia clones heterozygous for flower color (blue/pink, the blue being dominant) to low-level radiation and chemical mutagens, as demonstrated in the last decade, seem to endorse this system to be the most promising biological tester for detecting the genetic effects of mutagens at low levels. Two triploid (thus sterile) clones, KU 7 and KU 9, have been established as those suitable for in situ monitoring of environmental mutagens. In situ monitoring with such Tradescantia clones was first tried in 1974 around a nuclear power plant in Japan, then has been repeated until 1979 around more nuclear plants. About 260,000 to 1,570,000 stamen hairs were observed per year per nuclear plant (about 12-million hairs in total), and the data of pink mutation frequency were analyzed statistically. Significantly increased mutation frequencies were observed and were correlated to the operation periods of the nuclear facilities and to predominant wind direction, but not to other environmental factors. Considering physical monitoring data of radiation dose in the air, internal exposure due to incorporation and concentration of man-made radioactive nuclides seems to be of a greater importance in increasing mutation incidence.
Correction to: The lncRNA UCA1 promotes proliferation, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs
Authors: Chao-Jie Wang, Chun-Chao Zhu, Jia Xu, Ming Wang, Wen-Yi Zhao, Qiang Liu, Gang Zhao, Zi-Zhen Zhang
Journal: Molecular Cancer (2021)
Pocket Body
Authors: David H. Rapaport
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Can we have safer cigarettes?
Journal: BMJ (1984)

Uk' I Liverpool is an extreme case but it illustrates many of the things that went wrong in the '60s and '70s.Phases II and III were started in 1968 and due for completion in 1974 at a cost of £11 8m.The contractor got into financial difficulties early on and the site was dogged by strikes and pay claims.In 1975 the contractor went out of business and first one then another contractor was brought in to finish it.There were extra costs for remedying defects, for increasing the content of the hospital, and for bringing it up to current regulations on energy use, the housing of animals, and-most important-fire safety.In 1976 the DHSS told the Public Accounts Committee that the final building, still not complete, would cost £54 19m much of it due to inflation.The hospital consisted of a two
NIH 'Research Risks Office' reprimands hospital institutional review board
Authors: C. Marwick
Journal: JAMA (1990)

IN WHAT is believed to be a unique action, the Office for Protection from Research Risks at the National Institutes of Health (NIH) has reprimanded an institutional review board for failing to ensure that all subjects in a clinical trial were informed. There have been instances when investigators have failed to protect research subjects properly, but none involving institutional review boards, according to Charles R. McCarthy, PhD, director of the research risks office in Bethesda, Md. McCarthy and the deputy director of the office, Alan L. Sandler, DDS, jointly sent a letter to Peter H. Wolff, MD, chair of the committee on clinical investigation at Children's Hospital, Boston, Mass, pointing out that prerandomization to a study is unacceptable when consent is being sought in only one arm of that study. Prerandomization is a procedure in which patients are randomized to receive the treatments that are being tested before being asked