tbuckley/cabot-search huggingface dataset:
Text-Book of General Pathology. By Various Authors.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment patterns and clinical outcomes of patients with metastatic gastroenteropancreatic neuroendocrine tumors (mGEP-NETs).
Authors: Xiaolong Jiao, Sonia J. Pulgar, Marley Boyd, Fadi S. Braiteh, Susan Pitman Lowenthal, David Cox, Patricia S. Fox, Andrew Scott Paulson
Journal: Journal of Clinical Oncology (2016)

e15659 Background: mGEP-NETs are rare and heterogeneous tumors. Limited data has been published on real world clinical management of these tumors. This study was conducted to understand the treatment patterns and clinical outcomes of patients with mGEP-NETs treated in the community oncology setting. Methods: A retrospective study was conducted using US Oncology’s (USON) iKnowMed electronic health record (EHR) database with supplemental chart review. The first diagnostic record of mGEP-NET in the EHR system was defined as the date of diagnosis of mGEP-NET. Inclusion criteria: ≥ 18 years of age at diagnosis; diagnosis of mGEP-NET between 1/1/2008 to 12/31/2012. Patients in clinical trials or with poorly differentiated tumors were excluded. Results: 229 patients were included with a median age of 64.0 years. Primary tumor site included small bowel (47.6%), pancreas (31.4%), and other (21.0%). Tumor grade was available for 134/229 (58.5%) patients, and the majority was reported as well-differentiated (52.8%). Chromogranin A (CgA) and urinary 5-HIAA were reported for 34.9%, and 32.8% of patients respectively. 37 (16.2%) of patients were under observation only. For those receiving systemic treatment, median time to first systemic treatment after diagnosis was 2.7 weeks, with 75% of patients starting therapy by 9.4 weeks. 120 (52.4%) patients received only somatostatin analogs (SSAs) during the study period, and 72 (31.4%) patients received chemotherapy, and/or targeted therapy. In the 1st line setting (n = 192), 148 (77%) patients received SSAs, 23 (12%) chemotherapy, and 21 (10.9%) targeted therapy. The most common AEs for SSAs were diarrhea (18.2%), abdominal pain (16.9%), and fatigue (13.5%). The median overall survival (OS) from diagnosis was 68.0 months [95%CI 57.1, -] for the overall cohort. OS was longer in small bowel NETs than in pancreatic or other NETs (median OS 68.0 vs 49.1 vs Not reached, p = 0.016). Conclusions: Most of the patients with mGEP-NETs received systemic treatment soon after diagnosis and referral to USON. The OS and AEs were consistent with other studies. Low reporting of CgA, 5-HIAA, and tumor grade reflected variability of clinical practice in the community setting.
Physician Reporting of Aircraft Pilot Impairments
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUSPECTED ASYNCHRONISM OF RESPIRATORY MOVEMENTS IN LOBAR PNEUMONIA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
La vida del enfermo y su interpretación: Anamnesis
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Placenta Increta
Authors: Pradip Dashraath, Harvard Z Lin
Journal: New England Journal of Medicine (2016)

A 38-year-old woman who had undergone three low-segment cesarean sections was admitted in labor at 36 weeks of gestation. Ultrasonography suggested placenta accreta, with irregular vascular spaces and loss of retroplacental hypoechoic stripe. She underwent an emergency cesarean section.
Ethological and Experimental Approaches to Behavior Analysis: Implications for Ecotoxicology
Authors: Jeffrey Cohn, Robert C. MacPhail
Journal: Environmental Health Perspectives (1996)

Laboratory research in toxicology has progressed far beyond reliance on measures of mortality to make use of sophisticated behavioral preparations that can evaluate the consequences of sublethal toxicant exposure.In contrast, field studies have not evolved as rapidly.Approaches developed by experimental psychologists and ethologists provide powerful and complementary methodologies to the study of environmental pollutants and behavior.Observational data collection techniques can easily be used to broaden the number of questions addressed regarding sublethal exposure to toxic agents in both field and laboratory environments.This paper provides a background in such techniques, including construction of ethograms and observational methodologies, and the use of laboratory analogues to naturally occurring activities such as social behavior, predation, and foraging.Combining ethological and experimental approaches in behavior analysis can result in a more comprehensive evaluation of the effects of environmental contaminants on behavior.
A MODIFICATION OF VASOSTOMY PERMITTING FREQUENT IRRIGATIONS OF THE VESICLES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: M. THERESE Southgate
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Prospective Comparison of Neuropsychologic Performance of Children Surviving Leukemia Who Received 18-Gy, 24-Gy, or No Cranial Irradiation
Authors: Raymond K. Mulhern, Diane Fairclough, Judith Ochs
Journal: Journal of Clinical Oncology (1991)

Table 1 of the report "A Prospective Comparison of Neuropsychologic Performance of Children Surviving Leukemia Who Received 18-Gy, 24-Gy, or No Cranial Irradiation" (J Clin Oncol 9:1348–1356, 1991) contained an error. lt is reprinted here correctly in its entirety: Please see the PDF for Table.
SCIENCE AND ART IN MEDICINE. THEIR INFLUENCE ON THE DEVELOPMENT OF MEDICAL THINKING.*
Journal: JAMA (2006)

epiploic or gastro-duodenal artery, and progressively tie and cut away the gastro-eolic omentum distal to the glands and vessels up to the appropriate point on the greater curvature and here ligate the left gastro-epiploic vessels.Step 4. Double clamp the duodenum, divide between with the cautery leaving one-fourth inch projection.With a run- ning suture of catgut through the seared stump, the end of the duodenum is closed as the clamp is removed.A purse string suture about the duodenum enables the stump to be in- verted.The proximal end of the stomach is double-clamped, along the Mikulicz-Hartmann line, divided with cautery, leav- one-quarter inch in projection.Suture through the seared stump with a catgut buttonhole suture.This is again turned in, after removal of the clamp by a continuous silk or Cushing suture.Step 5. Independent gastro-jejunostomy.Step 6. Closure of the wound.Petersen says :Resection is practiced more than it was because : ( 1 ) Resec- tion is not more hazardous than gastro-enterostomy.Twice as many patients die from pneumonia after the latter than after the former operation.The removal of the decomposing cancerous tissue appears to be of great value. (2)The pros- pect of radical cure is much greater than was thought.The stomach and duodenum must be excised as widely as possible.(3) Even when recurrence takes place, resection prolongs life on an average about nine months, as opposed to the four to five months of its rival.
MPTP: An Industrial Chemical and Contaminant of Illicit Narcotics Stimulates a New Era in Research on Parkinson's Disease
Authors: I. J. Kopin
Journal: Environmental Health Perspectives (1987)

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) causes selective destruction of dopaminergic neurons of the nigrostriatal pathway in humans and other primates. It is less specific and much less potent in mice and has only slight effects in rats. Differences in rates and sites of metabolism of MPTP to its active, toxic, highly polar metabolite, MPP+ (1-methyl-4-phenylpyridine), appear to influence species specificity. In rats, type B monoamine oxidase (MAO-B), which mediates the conversion of MPTP to MPP+, may act as an enzymatic barrier at brain microvessels, whereas in primates the enzyme, present mainly in astrocytes, appears important for bioactivation of MPTP into the toxic metabolite. MPP+ is a substrate for catecholamine uptake sites and is concentrated in these neurons. The molecular mechanism of MPP+ toxicity has not been established definitively, but conversion to a free radical or uptake by mitochondria and inhibition of mitochondrial respiratory enzymes, leading to calcium release and cell death have been suggested. The discovery of toxin which causes an animal model of Parkinson's disease has stimulated new research on environmental factors that might contribute to this progressive degenerative disorder and provides a means for assessing new approaches to therapy.
Quality in health care
Authors: G. Laffel
Journal: JAMA (1992)

The connection between generating new knowledge in medical research and putting that knowledge to use in medical practice is remarkably tenuous. In order to ensure and improve the quality of health care, the health care system apparently needs better ways to integrate the lessons of research into the routine activities of care. Recent investigations have focused on the degree to which physicians accept and apply new findings and on the methods by which health care organizations support the integration of new knowledge into routine care. Several research groups have illustrated how wide the gap is between technically possible quality and the quality actually achieved at the front line of medicine. In the Harvard Medical Practice Study,<sup>1-3</sup>for example, investigators reviewed 30 000 randomly selected records from acute care hospitals and found that adverse events (injuries caused by medical management that prolonged hospitalization or produced disability at the time of
A Carcinogenic Potency Database of the Standardized Results of Animal Bioassays
Authors: Lois Swirsky Gold, Charles B. Sawyer, Renae Magaw, Georganne M. Backman, Margarita de Veciana, Robert Levinson, N. Kim Hooper, William R. Havender, Leslie Bernstein, Richard Peto, Malcolm C. Pike, Bruce N. Ames
Journal: Environmental Health Perspectives (1984)

The preceding paper described our numerical index of carcinogenic potency, the TD50 and the statistical procedures adopted for estimating it from experimental data. This paper presents the Carcinogenic Potency Database, which includes results of about 3000 long-term, chronic experiments of 770 test compounds. Part II is a discussion of the sources of our data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. Part III is a guide to the plot of results presented in Part IV. A number of appendices are provided to facilitate use of the database. The plot includes information about chronic cancer tests in mammals, such as dose and other aspects of experimental protocol, histopathology and tumor incidence, TD50 and its statistical significance, dose response, author's opinion and literature reference. The plot readily permits comparisons of carcinogenic potency and many other aspects of cancer tests; it also provides quantitative information about negative tests. The range of carcinogenic potency is over 10 million-fold.
Reply
Authors: M. L Burr
Journal: Thorax (1986)

Chemotherapy in non-small cell bronchial carcinoma SIR,-In the first paragraph of your editorial on the chemotherapy of non-small cell bronchial carcinoma (September 1985;40:641-5) it is stated that very few patients with squamous or large cell carcinoma or adenocarcinoma of the lung are cured by surgery.This is indeed true in relation to the total number of cases of lung cancer each year, but on the other hand it should be emphasised that in the relatively small group of patients who are suitable for surgical treat- ment the five year survival rate (operative mortality ex- cluded) is as high as 25% (to be precise 25.5-26.8% in the review by Belcher of 8781 patients with bronchial carcinoma operated on by seven surgeons in England during the years
Reply
Authors: D B A Silk
Journal: Gut (1989)

Fibre and enteral nutrition SIR,-We read with great interest Dr Silk's review,' but we were surprised at the omission of any detail on the effects of enteral nutrition on cholesterol metabolism.In our own experimental studies,' rats fed for 10 weeks with Vivonex develop severe fatty infiltration of the liver, similar to Kwashiorkor, with initial deposition of fat in the periportal regions with progressive involvement around the central vein with significant quantitative increases in total liver lipid and cholesterol.No such changes were detectable in the livers of animals fed for 10 weeks with Vivonex which was supplemented with 5% wheat bran.The accumulation of lipids and cholesterol in the livers of rats fed Vivonex has been reported by others.' We concluded that dietary bran thus appears to play a role in maintaining normal lipid metabolism and suggest that caution be exercised in those patients on longterm enteral feeding with careful monitoring of blood lipids.
Choosing Geriatrics
Authors: Helen Fernandez
Journal: Annals of Internal Medicine (2006)

On Being a Doctor5 December 2006Choosing GeriatricsHelen Fernandez, MDHelen Fernandez, MDFrom Mount Sinai School of Medicine, New York City, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-11-200612050-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail We were riding in a cab to visit a patient's home on Madison Avenue. My colleague read the triage sheet. “He is an older guy with diabetes, renal disease, heart disease, recently signed out of the nursing home.” I thought how unusual it was for anyone to sign out of a nursing home. “He's been to the ER for chest pain, but signed himself out of there, too.” Our job this morning was to determine if the chest pain was serious enough to require his admission to the hospital.The patient's close friend greeted us at the door of a ... Author, Article, and Disclosure InformationAffiliations: From Mount Sinai School of Medicine, New York City, New York.Corresponding Author: Helen Fernandez, MD, Department of Geriatrics, Box 1070, One Gustave Levy Place, New York, NY 10029; e-mail, helen.[email protected]edu PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 December 2006Volume 145, Issue 11Page: 862-863KeywordsEmotionsFoodGeriatricsIschemiaNursing homesResidencySmellSoapsStroke ePublished: 5 December 2006 Issue Published: 5 December 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Continuing medical education. The next step
Authors: P. R. Manning
Journal: JAMA (1983)

Traditional continuing medical education (CME) keeps physicians aware of the state of the art. It has limitations, however, as a qualityassurance tool: it is memory based, involves a group endeavor with diffuse goals, often unrelated to practice, is an inappropriate remedy for many problems in patient care, is hampered by poor-quality evaluation, and is governed more by market factors than educational outcomes. The self-study of practice and practice-linked CME offer rich potential for development. The physician's monitoring of his work, with appropriate improvements in performance, is valuable CME. Computers provide facts and guidance at the time and place the physician is developing diagnostic plans, diminishing reliance on memory. The next step in CME is for hospitals, societies, and medical schools to perfect methods of self-study of practice and practice-linked CME. (<i>JAMA</i>1983;249:1042-1045)
AXL inhibition prevents NAFLD progression in mice with soluble AXL as marker of the NAFLD to NASH transition
Authors: Anna Tutusaus, Estefanía de Gregorio, Blanca Cucarull, Isabel Graupera, Mar Coll, Sturla M Grondal, Gro Gausdal, James B Lores, Pablo Garcia de Frutos, Albert Morales, Montserrat Marí
Journal: Journal of Hepatology (2020)
A Health-Based Approach for Sampling Shallow Soils at Hazardous Waste Sites Using the AAL soil contact Criterion
Authors: Paul W. Hadley, Richard M. Sedman
Journal: Environmental Health Perspectives (1990)

Strategies for sampling shallow soils at hazardous waste sites are employed primarily to evalu- ate levels and distributions of contamination.The ensuing analyses of potential public health impacts are therefore dependent on the sampling design rather than having the sampling design based on the data needs for evaluating potential public health impacts of shallow soil contamina- tion.We define a specific objective that guides the sampling of shallow soils.The sampling results can thereby be directly employed to evaluate potential public health impacts from direct contact exposures to shallow soil contamination.