tbuckley/cabot-search huggingface dataset:
Complication of a Hickman catheter. Cutaneous erosion of the Dacron cuff
Authors: W. B. Fisher
Journal: JAMA (1985)

INDWELLING central venous silicone rubber catheters (Broviac and Hickman) have gained widespread acceptance in patients requiring parenteral nutritional support or repeated venous access for cancer chemotherapy. Complications following catheter placement have been rare and include bacteremia, fungemia, local infection, hematoma formation, and catheter malfunction including migration, breakage, and occlusion.<sup>1,2</sup>Virtually no reports of significant complications following catheter removal have been published. The following case report describes the spontaneous cutaneous erosion of a retained Dacron cuff nine months after Hickman catheter removal. <h3>Report of a Case</h3> A 24-year-old man was found to have an osteogenic sarcoma of the right humerus in February 1979. He was referred to a physician at Memorial Hospital in New York and received preoperative chemotherapy, limb-sparing surgical resection, and postoperative chemotherapy (T-10 protocol).<sup>3</sup>In April 1983 he developed a recurrence in the apex of his right lung, with thoracic outlet involvement. He returned to Memorial
Prevalence of hepatitis B markers and measles, mumps, and rubella antibodies among Jewish refugees from the former Soviet Union
Authors: M. B. Hurie
Journal: JAMA (1995)

<h3>Objective.</h3> —To assess the prevalence of hepatitis B virus (HBV) infection and immunity to measles, mumps, and rubella among refugees from the former Soviet Union (FSU). <h3>Design.</h3> —Descriptive study. <h3>Setting.</h3> —Soviet Immigrant Health Care Program, Sinai Samaritan Hospital, Milwaukee, Wis. <h3>Patients.</h3> —Consecutive sample of 496 Jewish refugees from the FSU presenting for new arrival screening from December 1, 1990, through January 11, 1993. <h3>Outcome Measures.</h3> —Hepatitis B surface antigen (HBsAg), hepatitis B core antibody, hepatitis B surface antibody, and measles, mumps, and rubella antibodies. <h3>Results.</h3> —At least one hepatitis B marker was detected in 22% of the refugees, and HBsAg was detected in 0.4%. The rate of HBV infection (any marker present) increased with increasing age, ranging from 4% among those aged 0 through 19 years to 31% among those aged 50 through 59 years (χ<sup>2</sup>test for trend, 13.5;<i>P</i>&lt;.001). Among those aged 0 through 19 years, 19% lacked antibody to measles, 8% lacked antibody to mumps, and 13% lacked antibody to rubella. Refugees who were less than 30 years of age were more than twice as likely to lack antibodies to measles, mumps, or rubella compared with those who were 30 years of age or older (relative risk, 2.8; 95% confidence interval, 1.8 to 4.2;<i>P</i>&lt;.001). <h3>Conclusions.</h3> —In our sample of Jewish refugees from the FSU (primarily Ukraine, Russia, and Belorussia), the rate of HBsAg positivity was low, suggesting that routine screening for HBV infection is not needed. Seronegativity to measles, mumps, and rubella was relatively common among those less than 30 years old. Those refugees who were born after 1957 should be given combined measles, mumps, and rubella vaccine unless their written documentation indicates previous receipt of these antigens according to the immunization schedule recommended in the United States. (<i>JAMA</i>. 1995;273:954-956)
化脓性汗腺炎Hurley分级评分者间和评分者内可靠性
Authors: Z.N. Ovadja, M.M. Schuit, C.M.A.M. Horst, O. Lapid
Journal: British Journal of Dermatology (2019)

在患者就诊时疾病分级是估计疾病的后续病程(预后)及任何治疗的可能疗效的一个重要部分。分级是指正式评估疾病的严重性, 包括程度(例如, 受影响皮肤的面积)。化脓性汗腺炎(HS)是一种在身体褶皱部位出现的慢性皮肤炎症(如腹股沟或腋窝),在这些部位出现脓疮和脓疱, 因此可能导致结疤。至少有4种不同评分方法用于疾病分级, 其中最常用的是Hurley分级法。本研究是德国、丹麦和波兰不同科室间的一次国际合作, 旨在审查不同皮肤科医生(包括实习医生)在两种不同情况下对5名不同患者HS分级评定的一致性。测验显示在不同医生间及同一医生在不同情况下都很难获得一致评估。在不同医生间或同一医生在不同情况下一致性都最高的评分方法是国际化脓性汗腺炎评分系统及HS医师整体评估量表。作者强调了培训医生对如何使用这些评分系统以最大限度地利用其优点的重要性。
Clonal Dynamics and Clinical Implications of Post-Remission Clonal Hematopoiesis in Acute Myeloid Leukemia (AML)
Authors: Tomoyuki Tanaka, Kiyomi Morita, Feng Wang, Latasha Little, Curtis Gumbs, Jairo Matthews, Courtney D. DiNardo, Tapan M. Kadia, Farhad Ravandi, Marina Y Konopleva, Hagop M. Kantarjian, Richard E. Champlin, Guillermo Garcia-Manero, P Andrew Futreal, Koichi Takahashi
Journal: Blood (2019)
Narcissus, Pogo and Lew Thomas' wager
Authors: R. J. Bulger
Journal: JAMA (1981)

<i>I have seen the enemy and he is us</i>.—Pogo ANY ANALYSIS of ethical issues in health policy has to begin with the distressing admission that our civilization's fundamental values are now in question and that what social critics and psychiatrists are calling "narcissism" is undermining our society. As I tried to get excited about attempting an explication of one or another of the ethical issues in health policy, I found myself returning to the four major words in the society's name: "society," "health," and "human values," and a growing feeling that there are higher-priority questions our nation and civilization must settle before the ethical issues in health policy can be sensibly addressed. Thus, I am led to offer a personal view of our situation, painting with broad strokes from a variety of sources in the hope that there might be some implications for action. <h3>'Narcissism'</h3> Just as in
Antiarrhythmic effects of tricyclic antidepressants
Authors: M. E. Thase
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The report entitled "One Caution in Pneumatic Antishock Garment Use" concerns me greatly. The time course for the events from birth is described sketchily. One is left with the impression that the patient underwent cardiopulmonary resuscitation for a considerable interval (how soon after parturition?) before help was summoned. Proper application of the pneumatic antishock garment after an interval of seven minutes without vital signs would increase intraabdominal and inferior vena caval pressure<sup>1</sup>and act as a barrier to cephalad migration of blood<sup>2</sup>and, presumably, air. Creation of a<i>negative</i>intrathoracic pressure would also be obviated by mechanical ventilation. One should look more closely at the negative intrathoracic pressures created on the release of chest compression during cardiopulmonary resuscitation before sounding an alarm against therapy with the pneumatic antishock garment. To deny therapy of potential lifesaving magnitude like that of a properly applied pneumatic antishock garment
Large trials vs meta-analysis of smaller trials
Authors: M. A. Klebanoff
Journal: JAMA (1997)

<h3>In Reply.</h3> —As indicated by Dr Havas, significant savings can be gained through primary prevention of chronic disease. While it seemed implicit to us, the message of prevention always bears reinforcing. In addition, it is important to recognize another large source of potential savings—both in dollars and human suffering—from the prevention of secondary conditions. Secondary conditions are diseases, impairments, functional limitations, or additional disabilities that are caused by (ie, occur as a result of) another condition.<sup>1</sup>Crucially important to preventing these sequelae is a health care system that ensures continuity of care, access to assistive technology and resources, and health education—fundamental elements that enable individuals to manage their own health care effectively and prevent further illness and disability. It was our hope that, by measuring the total prevalence and costs of chronic conditions as a whole, the need for both primary prevention of chronic conditions and the secondary prevention of disability
THE "MEDICAL INSTITUTE" FRAUDS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Locoregional hyperthermia in combination with chemotherapy for metastatic breast cancer patients: The Mammatherm- trial
Authors: J. K. Jueckstock, B. Strobl, M. Heinrigs, W. J. Janni, H. L. Sommer, K. Friese
Journal: Journal of Clinical Oncology (2008)

12027 Background: Treatment options for patients with metastatic breast cancer should be both as effective and preferably as little toxic as possible. However to date there is no standard therapy available but treatment regimens for metastatic breast cancer vary much. Locoregional hyperthermia might show additive effects to chemotherapy due to an increased perfusion and a simultaneous occurring of interstitial acidosis in tumor tissue. Methods: Primary objective of the multicenter prospectively randomized phase I/II German Mammatherm-trial is to evaluate if metastatic breast cancer patients benefit from locoregional hyperthermia given additionally to a chemotherapy regimen regarding progression free survival. Phase I of this study is a dose-finding-study for liposomal doxorubicin administered in combination with locoregional hyperthermia. Dose-escalation-levels are at 40/50/60 mg/m2 and in each level 3 patients have to be treated without showing severe toxicity. The first eligible patient (i.e. metastatic lesions accessible to locoregional hyperthermia) entered the study in August 2007 and 9 more patients are needed until the study can proceed to phase II. Phase II (recruitment of 300 patients planned) will compare 2 different treatment regimens in a randomized setting: Arm A comprises 6 cycles of liposomal doxorubicin 40/50/60 mg/m2 (final dose to be defined after phase I) i.v. d1 q22d×6 and cisplatin 20 mg/m2 i.v. d1, 8, 15 q22d×6 in combination with locoregional hyperthermia administered at d1, 4, 8, 11, 15, 18 q22d×6. In arm B patients are treated according to the same chemotherapy regimen but without adding the hyperthermic treatment. Results: Intentions of the study are that patients in the experimental arm will benefit from locoregional hyperthermia administered additionally to chemotherapy, i.e. that progression free survival as well as overall survival (as secondary study objective) can be prolonged significantly without being accompanied by increased toxicity or reduced quality of life. First results for phase I are expected by the end of 2008. Conclusions: The Mammatherm-trial will show if metastatic breast cancer patients have a prolonged progression free survival by adding locoregional hyperthermia to a chemotherapy regimen. No significant financial relationships to disclose.
Smokeless Tobacco Use in the United States
Journal: JNCI Journal of the National Cancer Institute (1990)

Smokeless Tobacco Use in the United States Get access JNCI: Journal of the National Cancer Institute, Volume 82, Issue 3, 7 February 1990, Page 233, https://doi.org/10.1093/jnci/82.3.233 Published: 07 February 1990
X-Rays Past and Present.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac Emergencies
Authors: Raymond Harris
Journal: JAMA (1977)

Eliot and his crew of associate editors and experts have combined their writing and investigative talents to produce a well-edited and appealing book on<i>Cardiac Emergencies</i>. It provides useful knowledge and information about the pathophysiology, diagnosis, and management of catastrophic cardiac complications, the bete noire of most physicians. This book focuses attention not only on why these troublesome situations arise but also on how to treat them. Section 1 summarizes current research on the pathophysiology of coronary heart disease, myocardial infarction, shock, congestive heart failure, and cardiac arrhythmias. Sections 2 and 3 offer clinically useful advice and recommendations for the recognition, diagnosis, and care of these major cardiovascular emergencies. Among its many good features is a chapter on syncope by Drs Dunn and Carley, with comprehensive tables and a clinically handy evaluation chart for pinpointing the cardiovascular causes of syncope. Illustrations are excellently reproduced, especially those in a chapter entitled
AB0406 A Study on Characteristics of Rheumatoid Arthritis Patients Achieving no Depression with 6 Months of Biologic Treatment
Authors: Y. Miwa, R. Takahashi, R. Yanai, H. Furuya, M. Umemura, Y. Miura, T. Kasama, K. Oh, Y. Toyoshima, K. Inagaki, M. Hosaka
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> It is known that rheumatoid arthritis (RA) is comorbid with various diseases, and especially concomitant depression is common with a high prevalence of approximately 20%. Even if RA disease activity is controlled, patients with persistent depression result in decreased ADL and QOL. <h3>Objectives</h3> To study predictive factors for no depression status after using biologic agents for 6 months. <h3>Methods</h3> The subjects were 333 RA patients treated with biologic agents. The following patient9s characteristics were investigated: age, gender, the number of previous drugs, disease duration, the type of biologic agents, baseline steroid dosage, MTX dosage, serum RF, MMP-3, ACPA, TNF-α, and IL-6. For evaluation we used SDAI for RA disease activity, HAQ for ADL, Short Form (SF)-36 for QOL, and Hamilton Depression Rating Scale (HAM-D) or Self-rating depression scale (SDS) for depression status. No depression was defined by HAM-D7 or SDS39 after 6 months of treatment. The subjects were divided into two groups according to the presence or absence of depression, and a retrospective study was performed. We excluded 101 patients due to loss to 6-month follow-up and 39 patients due to incomplete data; therefore, we included 193 patients in the analysis. <h3>Results</h3> Compared with a group of RA patients with depression (n=130), a group of patients without depression (n=63) had younger age (52.7±14.8 vs. 59.8±14.3, p=0.002), more males (p=0.046), lower baseline steroid dosage (3.2±3.1mg vs. 5.0±4.4mg, p=0.002), lower SDAI (22.9±12.8 vs. 29.5±15.2, p=0.002), lower HAQ (0.43±0.47 vs. 0.75±0.62, p&lt;0.001), higher SF-36 (p&lt;0.05 in all categories), lower SDS (38.2±8.5 vs. 46.7±9.6, p&lt;0.001), and lower HAM-D (5.0±4.0 vs. 9.3±6.0, p&lt;0.001). On the other hand, there was no significant difference on the types of biologic agents, the order of drugs used in the treatment, MTX dosage, disease duration, serum RF, MMP-3, ACPA, TNF-α, and IL-6. <h3>Conclusions</h3> It was suggested that RA patients with lower disease activity, lower dosage of steroid, younger age, higher ADL and QOL, and lower depression scores at baseline are more likely to achieve no depression status with biologic treatment. <h3>Disclosure of Interest</h3> Y. Miwa Grant/research support from: Astellas Pharm Inc., Mitsubishi Tanabe Pharma Corporation, AbbVie CK, Pfizer Japan Inc., Chugai Pharmaceutical Co., Ltd., and Eizai Co., Ltd., R. Takahashi: None declared, R. Yanai: None declared, H. Furuya: None declared, M. Umemura: None declared, Y. Miura: None declared, T. Kasama: None declared, K. Oh: None declared, Y. Toyoshima: None declared, K. Inagaki: None declared, M. Hosaka: None declared
Asthma in the Workplace
Journal: Thorax (1993)

We do not accept Dr Miller's contention that the lesions described in her series and ours ought to be considered as bronchiolo- alveolar cell adenomas.The lesions are generally characterised by nuclear pleomor- phism and a high nucleocytoplasmic ratio- features not normally associated with a benign neoplasm.We feel strongly that these features are much more consistent with premalignant dysplastic lesions seen at other sites-including the bronchus-hence our preference for "atypical hyperplasia."
Summary of the Cleveland inquiry.
Journal: BMJ (1988)

The report of Lord Justice Butler-Sloss on her inquiry into child abuse in Cleveland was published on 6 July (HMSO, Cm 412), together with a 21 page summary of the main events and findings (HMSO, Cm 413) and several pamphlets of guidelines from the Department of Health and Social Security and the Department of Education and Science dealing with the sexual abuse of children.During the crisis in Cleveland, which developed over a period of about five months, 125 children were diagnosed as sexually abused, of whom 98 have now been returned home.Proceedings in 27 wardship cases were dismissed.This article summarises the main findings of the report. The eventsCleveland's social services had a good record of response to issues of child care.Its growing concern about the problem of child sexual abuse led to the appointment in June 1986 of Mrs Susan Richardson, a former social work team leader, to the new post of child abuse consultant.On 1 January 1987 Dr Marietta Higgs began working as consultant paediatrician in South Tees Health District.Dr Higgs had established an interest in child sexual abuse through previous work as a senior registrar in Newcastle and her contact with the research and teaching of the Leeds paediatrician Dr Jane Wynne, who, with Dr Christopher Hobbs, had published an article in the Lancet describing the sign of anal dilatation in the diagnosis of buggery in children, which they considered to be a common form of abuse.Dr Higgs quickly established a close working relationship with Mrs Richardson.In February she
Home Hemodialysis With Subcutaneous Arteriovenous Fistula
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Graduate Medical Education in the United States
Authors: Anne E. Crowley
Journal: JAMA (1983)

<i>This section is a reprint from the 1983-1984</i>Directory of Accredited Residency Training Programs. <h3>INTRODUCTION</h3> This annual report on graduate medical education in the United States contains data on number of residency programs by specialty and by region, number of positions offered, number of trainees by specialty and by region, and number of foreign medical graduates in each specialty and in each state and information on the ethnic background and on the citizenship of trainees. This edition also contains some trend information, with comparable 1980, 1981, and 1982 statistics. <h3>METHODOLOGY</h3> The accreditation actions of the Residency Review Committees and of the Accreditation Council for Graduate Medical Education (ACGME) are recorded monthly. Statistical information on graduate medical education in the United States is collected annually by means of two surveys, one of program directors and one of institutions and agencies that participate to a significant extent in graduate medical education. In
Calcium blockers: more than angina
Authors: B. Merz
Journal: JAMA (1982)

Calcium entry blockers, a class of drugs of which two—verapamil and nifedipine—have been approved by the Food and Drug Administration for the treatment of angina, have begun to show promise in certain other disorders involving smooth muscle as well. One such disorder is essential hypertension. Trials with both FDA-approved drugs have been in progress in Europe and Japan since the early 1970s and have yielded almost uniformly encouraging results. Among physicians in the United States who have administered the drugs to patients with hypertension on an individual basis, the feeling is one of cautious optimism. Other disorders are those that involve spasms in smooth muscle, such as asthma, achalasia, myometrial contractions, and migraine. Here, however, most investigators agree that it is much too early to issue a verdict. David Tinkleman, MD, assistant clinical professor of pediatrics at the Medical College of Georgia School of Medicine in Augusta, is conducting a
RESULTS OF RESEARCHES IN BACTERIOLOGY.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal