tbuckley/cabot-search huggingface dataset:
Aerosolized Pentamidine
Authors: Stephen M. Picea
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 April 1989Aerosolized PentamidineStephen M. Picea, MDStephen M. Picea, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-7-574_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their otherwise enlightening editorial, Armstrong and Bernard (1) are extremely ambiguous in their conclusion concerning the appropriateness of using aerosolized pentamidine for therapy (not prophylaxis) for pneumocystis infection.At one point, they state "aerosol therapy by itself is contraindicated," whereas in the last paragraph they conclude, "aerosol pentamidine should not be used for treatment ..." It is not clear if the authors feel it is appropriate to use aerosolized pentamidine as adjunctive therapy, pending further studies. A clarification would be appreciated....Reference1. ArmstrongBernard DE. Aerosol pentamidine [Editorial]. Ann Intern Med. 1989;109:852-4. LinkGoogle Scholar1. ArmstrongBernard DE. Aerosol pentamidine [Editorial]. Ann Intern Med. 1989;110:852-4. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1989Volume 110, Issue 7Page: 574-574KeywordsPneumocystisProphylaxis ePublished: 1 December 2008 Issue Published: 1 April 1989 PDF downloadLoading ...
The Biological Basis and Measurement of Thresholds
Authors: W. Aldridge
Journal: The Annual Review of Pharmacology and Toxicology (1986)

The Biological Basis and Measurement of Thresholds, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/pharmtox/26/1/annurev.pa.26.040186.000351-1.gif
Archives of Pathology, Chicago
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress Toward Global Eradication of Dracunculiasis, January 2004–July 2005
Journal: JAMA (2005)

In 1986, an estimated 3.5 million cases of dracunculiasis occurred in 20 countries, and 120 million persons were at risk for the disease. That year, the World Health Assembly adopted a resolution calling for the eradication of dracunculiasis, also known as Guinea worm disease. This report describes the status of the global dracunculiasis eradication program as of July 2005, indicating that, during January-July 2005, a total of 8,191 indigenous cases of dracunculiasis were reported from nine countries, with at least 150 million persons at risk. Despite the substantial reductions in dracunculiasis cases since 1986, eradication of dracunculiasis will require international commitment and ongoing surveillance and intensified interventions at national, state, and local levels.
From the authors
Authors: R. Pellegrino, V. Brusasco, R. O. Crapo, G. Viegi, J. Wanger, P. Gustafsson, M. R. Miller, R. T. McKay, R. Casaburi, N. McIntire, O. F. Pedersen, F. Burgos, R. Jensen, D. Navajas
Journal: European Respiratory Journal (2006)

We would like to thank P. Enright for giving us the opportunity to clarify some issues raised by the recently published interpretative strategies for lung function tests [1].P. Enright's letter is important in that it reinforces our shared belief that guidelines are always relative and complete consensus is a utopian ideal.It also clarifies why
Effects of Carbon Monoxide on Myocardial Ischemia
Authors: Elizabeth N. Allred, Eugene R. Bleecker, Bernard R. Chaitman, Thomas E. Dahms, Sidney O. Gottlieb, Jack D. Hackney, Marcello Pagano, Ronald H. Selvester, Sandra M. Walden, Jane Warren
Journal: Environmental Health Perspectives (1991)

The purpose of this study was to determine whether low doses of carbon monoxide (CO) exacerbate myocardial ischemia during a progressive exercise test. The effect of CO exposure was evaluated using the objective measure of time to development of electrocardiographic changes indicative of ischemia and the subjective measure of time to onset of angina. Sixty-three male subjects (41-75 years) with well-documented coronary artery disease, who had exertional angina pectoris and ischemic ST-segment changes in their electrocardiograms, were studied. Results from three randomized, double-blind test visits (room air, low and high CO) were compared. The effect of CO exposure was determined from the percent difference in the end points obtained on exercise tests performed before and after a 1-hr exposure to room air or CO. The exposures resulted in postexercise carboxyhemoglobin (COHb) levels of 0.6% +/- 0.3%, 2.0% +/- 0.1%, and 3.9% +/- 0.1%. The results obtained on the 2%-COHb day and 3.9%-COHb day were compared to those on the room air day. There were 5.1% (p = 0.01) and 12.1% (p less than or equal to 0.0001) decreases in the time to development of ischemic ST-segment changes after exposures producing 2.0 and 3.9% COHb, respectively, compared to the control day. In addition, there were 4.2% (p = 0.027) and 7.1% (p = 0.002) decreases in time to the onset of angina after exposures producing 2.0 and 3.9% COHb, respectively, compared to the control day. A significant dose-response relationship was found for the individual differences in the time to ST end point and angina for the pre- versus postexposure exercise tests at the three carboxyhemoglobin levels. These findings demonstrate that low doses of CO produce significant effects on cardiac function during exercise in subjects with coronary artery disease.
The independent practice association in theory and practice. Lessons from experience
Authors: B. N. Shenkin
Journal: JAMA (1995)

This article examines an advanced managed care area, the San Francisco East Bay Area in California, for basic organizational issues posed by managed care for the medical profession. Of the three basic structures found, the independent practice association (IPA) model is theoretically most promising. Unlike the integrated health plan, the IPA seeks to retain traditional practice autonomy. Unlike the isolating direct gatekeeper model, the IPA assembles physicians in self-directed groups to invent and implement solutions and to exert political influence upward. In practice, however, it has proved difficult to balance practice autonomy with IPA authority. Both large, successful East Bay Area IPAs show signs (perhaps inevitably) of favoring authority over autonomy, as shown by their policies on governance, membership, and administration. Several policies are suggested to help redress this balance. Medical leaders must act now, before all the evidence is in, or the institutions of the past—hospitals and insurance companies—will control our future. (<i>JAMA</i>. 1995;273:1937-1942)
Prevalence and awareness of sickle cell hemoglobin in a military population. Determination by a rapid screening method
Authors: R. A. Binder
Journal: JAMA (1970)

On a prospective study, 1,000 Negro military recruits were screened with a new rapid differential solubility test for sickle cell hemoglobin. A total of 75 had positive screening tests: 73 had sickle cell trait, 1 had sickle cell-hemoglobin C disease, and 1 had sickle-thalassemia disease. There were no false-positive or false-negatives detected. In only five of the 150 individuals questioned was there any awareness of sickle cell states. This test is rapid and reliable and routine screening of the Negro population accompanied by education and genetic counseling is recommended.
High-Resolution Genomic Profiling of Adult and Pediatric Core Binding Factor Acute Myeloid Leukemia Reveals New Recurrent Genomic Aberrations
Authors: W.M. Michael Kühn, Ina Radtke, Lars Bullinger, Salil Goorha, Jinjun Cheng, Jennifer Edelmann, Juliane Gohlke, Xiaoping Su, Peter Paschka, Stanley Pounds, Jürgen Krauter, Arnold Ganser, Asmaa Quessar, Raul Ribeiro, Verena I. Gaidzik, Sheila Shurtleff, Jan Krönke, Karlheinz Holzmann, Jing Ma, Richard F. Schlenk, Jeffrey E. Rubnitz, Konstanze Döhner, Hartmut Döhner, James R. Downing
Journal: Blood (2010)
Thermal Pollution Consequences of the Implementation of the President's Energy Message on Increased Coal Utilization
Authors: Frank L. Parker
Journal: Environmental Health Perspectives (1979)

The thermal consequences of coal utilization are most meaningfully assessed in comparison with the form of power generation replaced by coal which is most likely nuclear. The different effects are influenced by siting decisions and the intrinsic thermal efficiencies of the two fuel systems. Nuclear power plants discharge 50% more waste Rheat to the atmosphere through cooling towers or to a water body than coal-fired plants. Coal-fired plants require about 2/3 as much water as nuclear power plants. Nearly every property of water is affected nonlinearly by temperature, and biological effects may amplify these changes because protein denaturation takes place more rapidly above 30 degrees C and these high temperatures affect bactericidal and viricidal activity of chlorine compounds. Usually algal populations change from a dominance of diatoms and green algae to dominance by blue-green algae. All organisms experience elevated metabolic rates at higher temperatures which may affect total energy needs, foraging ability, reproduction, migration and susceptibility to disease. Intake structures inevitably draw many organisms into the cooling system of a power plant, but the number and kind are influenced by its location, configuration, and mode of operation. Use of water recirculation systems reduces water use and with it, the number of organisms entrained. Mechanical damage in the cooling system to small organisms is generally low, but fish and their larvae and eggs may be seriously damaged. Discharge effects may also be severe but are generally local. The near field, where there are strong shear velocities and rapid temperature changes are particularly stressful to fish, and stringent limitations on the timing and strength of discharges may be required to reduce these stresses to nondamaging levels. Off-stream cooling systems may increase cloudiness, ground fog, precipitation, temperature and local winds, but these effects generally extend no further than 1000 m even in winter. There is considerable potential for using condenser cooling water for agricultural and aquacultural purposes such as irrigation, frost protection, undersoil heating, greenhouse heating and climate control. However, over the next few decades little of this waste heat is likely to be used creatively. The thermal consequences of implementing NEP are locally serious but do not pose regional problems. Creative use of the waste heat for aquaculture, agriculture, cogeneration, and power for energy intensive industries can be a powerful means of mitigating undesirable effects.
Treatment of Iliac Artery Aneurysms by Percutaneous Implantation of Stent Grafts
Authors: D. Scheinert, M. Schröder, H. Steinkamp, J. Ludwig, G. Biamino
Journal: Circulation (2000)

Background —Iliac artery aneurysms have traditionally been treated by direct surgical reconstruction. Endovascular stent grafts have been developed to provide an effective but less invasive treatment option for patients with peripheral arterial aneurysms. Methods and Results —In 48 patients, a total of 53 endoprostheses (mean length 7.3 cm, mean diameter 8.1 mm) were implanted into the iliac arteries (common iliac artery n=29, external iliac artery n=19) for percutaneous exclusion of aneurysmal lesions. The technical success of complete exclusion of the aneurysm was achieved in 47 of 48 cases (97.9%). In 1 case, persistent perfusion through a collateral branch was detected; however, this aneurysm thrombosed spontaneously within 2 weeks. In all patients, graft patency was monitored by clinical examination, which included the standardized treadmill test with calculation of the ankle-brachial Doppler index and color-coded duplex ultrasound. Forty-two of the 48 patients (87.5%) underwent follow-up angiography. According to Kaplan-Meier life-table calculations, primary patency rates were 100% after 1 year, 97.9% after 2 years, 94.9% after 3 years, and 87.6% after 4 years. Serial contrast-enhanced spiral CT scans were performed to rule out late procedural failures and to assess growth progression of the lesions. No secondary leaks were observed. Furthermore, the aneurysm diameter had reduced from 24.8±8.0 mm to 23.1±6.6 mm at the last follow-up ( P =NS). Conclusions —Stent grafts are a safe and effective treatment option for iliac artery aneurysms and provide good long-term patency of the graft.
DERMATOLOGICAL SECTION
Journal: British Journal of Dermatology (1921)

British Journal of DermatologyVolume 33, Issue 3 p. 109-118 DERMATOLOGICAL SECTION First published: March 1921 https://doi.org/10.1111/j.1365-2133.1921.tb09028.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume33, Issue3March 1921Pages 109-118 RelatedInformation
Five-Year Findings of the Hypertension Detection and Follow-up Program
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Writer's cramp.
Journal: BMJ (1972)

bination of concentrate together with vitamin Ki was more effective than vitamin K, in managing cerebral haemorrhage resulting from anticoagulant overdosage is therefore of great interest.Another situation where the concentrate may be of value is in the coagulation failure of advanced parenchy- matous liver disease which does not respond to vitamin K1.More general use of the concentrates for conditions other than the rare congenital clotting defects would place a strain on production.The administration of concentrates results in excessively high levels of any of the four factors not deficient in the patient's blood, and though Bruning and Loeliger did not find this harmful in their patients the possibility of produc- ing thrombosis in patients with a predisposition to intravascular clotting must be considered.
基于内容的具有深度分类特征的皮肤镜图像检索诊断准确率
Authors: P. Tschandl, G. Argenziano, M. Razmara, J. Yap
Journal: British Journal of Dermatology (2019)

神经网络是以人脑为模型的计算机系统。神经网络可以学会自己检测颜色、形状和边缘等视觉元素,因此,它们在皮肤肿瘤的自动分类和诊断方面显示出了巨大的进步。不幸的是,在最常见的格式中,它们只提供最终的概率值,例如“5% 黑色素瘤、60% 痣、25% 脂溢性角化病”。虽然实验结果表明网络是相当准确的,但用户很难洞察预测,以及如何将预测与自己的决策过程相结合。让神经网络变得“可解释”的一个选项是让它在数据库中搜索并呈现类似的图像,就像在书上查找类似的病例一样——只是这样会更快、更全面。这也有一个好处,即当图像看起来与搜索到的皮肤病变没有任何相似之处时,用户立即知道不要相信这种情况下的自动分析。作者在本研究中表明,如果一个网络提供类似的图像,这些图像可以传达与传统的“5% 黑色素瘤、60% 痣、25% 脂溢性角化病”输出相同的准确性。他们进一步发现,只需搜索最多 16 幅相似的图像就足以提供这些信息。这项研究表明,简单地搜索相似的图像可以利用神经网络的预测能力,同时变得可以被最终用户理解。
Fugitive Pieces
Authors: Anne Michaels
Journal: Annals of Internal Medicine (1998)

Articles1 June 1998Fugitive PiecesAnne MichaelsAnne MichaelsSubmitted by: Reuven Sobel, MD; Halutza, IsraelAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-11-199806010-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When a man dies, his secrets bond like crystals, like frost on a window. His last breath obscures the glass.Anne MichaelsFugitive PiecesNew York: Alfred Knopf; 1997Submitted by:Reuven Sobel, MDHalutza IsraelSubmissions from readers are welcomed. If the quotation is published, the sender's name will be acknowledged. Please include a complete citation, as done for any reference. −The Editor. Author, Article, and Disclosure InformationAffiliations: Submitted by: Reuven Sobel, MD; Halutza, Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySensibility in applied ethics"Fighting Trauma": Silencing the Past in Alan Scott Haft's Harry Haft: Survivor of Auschwitz, Challenger of Rocky MarcianoCrossing the Frontiers of Death: A Journey Through War Memories and Continents in Anne Michaels' Fugitive PiecesAn Autochthonic Scent of Memory?The Scent of Memory: Strangers, Our Own and OthersCOMFORT AND SCANDAL OF MEMORYReal tanks and toy tanks: playing games with history in Roberto Benigni's La vita � bella/Life is BeautifulTrauma and the Memory of PoliticsSilence and the WordPosttraumatic stress disorder following political imprisonment: The role of mental defeat, alienation, and perceived permanent change.The Scent of Memory: Strangers, Our Own, and Others 1 June 1998Volume 128, Issue 11Page: 905 ePublished: 15 August 2000 Issue Published: 1 June 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Congenital Malaria as a Result of Plasmodium malariae--North Carolina, 2000
Journal: JAMA (2002)

Congenitally acquired malaria is rare in the United States; < or = 10 cases are reported each year. Congenital infection with Plasmodium malariae is particularly uncommon because distribution of this parasite is focal and sparse in areas where P. falciparum is endemic. The last case of congenital P. malariae infection in the United States was reported in 1992. This report describes the investigation of a case of P. malariae in an infant with no travel history outside of the United States and suggests that health-care providers suspect malaria when treating a neonate or young infant with fever if the mother has traveled or lived in a malarious area.
From the NIH: Use of folate analogue in treatment of methyl alcohol toxic reactions is studied
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alterations of Cytochrome P450-Dependent Monooxygenase Activities in Eriocheir japonicus in Response to Water Pollution
Authors: Mayumi Ishizuka, Hidenobu Hoshi, Nobuyuki Minamoto, Makihiko Masuda, Akio Kazusaka, Shoichi Fujita
Journal: Environmental Health Perspectives (1996)

Eriocheir japonicus, fresh-water crabs inhabiting rivers and estuaries in Japan, were investigated for cytochrome P450 (CYP)-dependent drug-metabolizing enzyme activities to see if these activities reflect the river pollution gradient. From the laboratory dose-response experiments, we found that the polycyclic aromatic hydrocarbon (PAH) 3-methylcholanthrene induced total CYP contents, ethoxycoumarin O-deethylase activity, and bunitrolol 4-hydroxylase activity in crab hepatopancreas. In the field studies, crabs collected from the river with the highest concentration of PAHs exhibited the highest levels of CYP, the highest activities of benzo[a]pyrene 3-hydroxylase, imipramine 2-hydroxylase, bunitrolol 4-hydroxylase, ethoxycoumarin O-deethylase, and the ability to metabolically activate benzo[a]pyrene, but erythromycin N-demethylase activity was not induced. The correlation between PAH levels and drug-metabolizing enzyme activities in female crabs were not as marked as in male crabs. The levels and activities of CYP did not appear to reflect the concentrations of organochlorines and polychlorinated biphenyl congeners (PCBs) studied in the fat of crab hepatopancreas.
WEST VIRGINIA OSTEOPATHIC BILL NOT PASSED.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal