tbuckley/cabot-search huggingface dataset:
AB0717 Risk association between scleroderma disease characteristics, periodontitis and tooth loss
Authors: G. Isola, R. Williams, A. Lo Gullo, M. Matarese, L. Ramaglia, G. Matarese
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Systemic Sclerosis (SSc (is a multi-system disorder that can have significant adverse effects upon the health of the mouth. <h3>Objectives</h3> The aim of this study was to investigate the associations between the disease characteristics of SSc, periodontal disease (PD) and tooth loss. <h3>Methods</h3> Fifty-four patients affected by SSc and 55 non-diseased controls were matched for age and gender. SSc was characterised in subtypes and with the mean duration of disease and the Modified Rodnan Skin Score [mRSS]. Patients were surveyed and examined through the evaluation of the periodontal parameters and the number of teeth. <h3>Results</h3> A logistic regression analysis showed that patients with SSc presented a higher number of missing teeth (p=0.001) and a significant median increased odds 2.95 (95% CI 1.26 to 6.84) of PD (defined as clinical attachment loss, CAL) compared to non-diseased controls (6.83, 95% CI 1.94 to 24.36). Moreover, the less values of PD was correlated with mRSS in the total SSc group and with the mean duration of disease in patients with limited SSc (p=0.007), even after adjusting this correlation with the presence of the major organs involvement. <h3>Conclusions</h3> This study showed that patients with SSc presented an increased odds of PD and tooth loss compared to non-diseased controls. In SSc patients, the magnitude of PD was strongly associated with the mRSS and with the mean duration of the disease. The clinicians should be aware of the potential systemic health problems related to PD. <h3>References</h3> [1] Matarese G, Isola G, Alibrandi A, et al. Occlusal and MRI characterizations in systemic sclerosis patients: A prospective study from Southern Italian cohort. Joint Bone Spine2016; 83: 57–62. [2] Matarese G, Isola G, Anastasi GP, et al. Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: a role of these biomarkers in the pathogenesis of scleroderma and periodontal disease. Int J ;<sup>Mol Med 2012</sup> 30: 502–8. <h3>Disclosure of Interest</h3> None declared
Hospital Medicine
Authors: Fred Chan, Rekha Motagi, Renu Thomas
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Protracted Intermittent Schedule of Topotecan in Children With Refractory Acute Leukemia: A Pediatric Oncology Group Study
Authors: Wayne L. Furman, Clinton F. Stewart, Mark Kirstein, James L. Kepner, Mark L. Bernstein, Faith Kung, Teresa J. Vietti, C. Philip Steuber, David Lee Becton, Sylvain Baruchel, Charles Pratt
Journal: Journal of Clinical Oncology (2002)

To determine dose-limiting toxicity (DLT) and maximum-tolerated dose (MTD) of a protracted, intermittent schedule of daily 30-minute infusions of topotecan (TPT) for up to 12 consecutive days, every 3 weeks, in children with refractory leukemia.Forty-nine children were enrolled onto this phase I trial (24 with acute nonlymphoblastic leukemia [ANLL] and 25 with acute lymphoblastic leukemia [ALL]). TPT dosage was escalated from 2.0 to 5.2 mg/m(2)/d for 5 days and 2.4 mg/m(2)/d from 7 days to the same dose for 9 and 12 days in cohorts of three to six patients when no DLT was identified. TPT pharmacokinetics were studied in 33 children once or twice (first and last doses in patients who received TPT for > 7 days).Seventy assessable courses of TPT were administered to 49 children who had refractory leukemia. DLTs were typhlitis, diarrhea, and mucositis, and the MTD was 2.4 mg/m(2)/d for 9 days in this group of heavily pretreated children. In 33 patients, the median TPT lactone clearance after the first dose was 19.2 L/h/m(2) (range, 9.4 to 45.9 L/h/m(2)) and did not change during the course. There were significant responses (one complete response [CR] and four partial responses [PR] in patients with ANLL and one CR and two PRs in patients with ALL), and all but one were at dosages of TPT given for at least 9 days.The MTD was 2.4 mg/m(2)/d for 9 days. Further testing is warranted of TPT's schedule dependence in children with leukemia.
Consensus or coercion
Authors: W. E. May
Journal: JAMA (1985)

There is an emerging issue that I have not heard much discussed, but that seems to me to pose a significant question. That is, will medicine be practiced in the future on the basis of the individual decisions of each physician and his patient, or will we see the development of a system of medical practice by consensus? Intrinsic to this question is the corollary: Which would be preferable? Medicine is practiced today by a host of individual physicians, each free within the broad constraints of reason to choose the most appropriate path to the diagnosis and treatment of each patient. At every decision point, a choice is made from a range of alternatives. In most cases, there is at least the theoretical possibility that one choice would represent the "best" among that particular set of alternatives. But, as the selection is influenced by the knowledge and experience of the
<i>Announcement</i>: World Water Day — March 22, 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

March 22 is Diabetes Alert Day, dedicated to raising awareness about type 2 diabetes, its risk factors, and its prevention.Type 2 diabetes, which accounts for 90%-95% of all cases of diagnosed diabetes in U.S. adults, might be prevented through lifestyle changes, such as losing weight and increasing physical activity (1,2).In the United States, 86 million adults have prediabetes, putting them at increased risk for developing type 2 diabetes, heart disease, and stroke.Only 10% of adults with prediabetes know they have it (1,3).In partnership with the Ad Council, the American Diabetes Association, and the American Medical Association, CDC's Division of Diabetes Translation developed and launched the first national prediabetes awareness campaign to encourage people to take steps to prevent type 2 diabetes.The website DoIHavePrediabetes.org(https://doihaveprediabetes.org) features a short test for people to find out their prediabetes risk and includes lifestyle tips and links to CDC-recognized prevention programs across the country that are part of the National Diabetes Prevention Program (http://www.cdc.gov/diabetes/prevention/index.html).The U.S. Diabetes Surveillance System includes an updated Diabetes State Atlas (http://www.cdc.gov/diabetes/data) that allows users to view data and trends on any mobile device.In addition to containing the latest state-level data, the atlas now presents estimates of the percentage of adults without diagnosed diabetes who report having had a test for diabetes or high blood glucose in the past 3 years.Additional information about diabetes prevention and control is available from CDC (http://www.cdc.gov/diabetes).
Abstract 18873: Al <sup>18</sup> F-NOTA-folate Accumulates in Atherosclerotic Plaques and Can be Detected by PET/CT
Authors: Johanna M Silvola, Xiang-Guo Li, Jenni Virta, Guru Prasad Padmasola, Päivi Marjamäki, Heidi Liljenbäck, Miikka Tarkia, Jarkko Hytönen, Virva Saunavaara, Seppo Ylä-Herttuala, Qingshou Chen, Philip S Low, Juhani Knuuti, Antti Saraste, Anne Roivainen
Journal: Circulation (2015)

Introduction:Macrophages are a major cell type in inflamed atherosclerotic plaques. Since folate receptor β (FR-β) is highly expressed in activated macrophages, we hypothesized that it might serve as a new marker for inflamed atherosclerotic plaques. Hypothesis: We aimed at evaluating a FR-β targeted PET tracer, Al 18 F NOTA-Folate, for the detection of inflamed atherosclerotic plaques. Methods:Atherosclerotic mice deficient for low density lipoprotein receptor (LDLR -/- ApoB 100/100 , n=12), C57BL control mice (n=9), and Watanabe rabbits (n=4) with endothelial denudation-induced atherosclerosis in the aorta were used. Biodistribution of Al 18 F-NOTA-Folate (specific radioactivity 130 GMq/μmol) was investigated in vivo by PET/contrast enhanced CT and ex vivo by gamma counting and autoradiography of aortic sections. In addition, prior to Al 18 F-NOTA-Folate study, the Watanabe rabbits were PET/CT imaged with 18 F-FDG. Results:Atherosclerotic mice demonstrated large and macrophage-rich atheromatous plaques in the aorta. The in vivo PET/CT revealed significantly higher uptake of Al 18 F-NOTA-Folate in the aortic arch of atherosclerotic mice compared to controls (aorta-to-blood ratio 1.5±0.3 vs. 0.7±0.2, P &lt;0.0001), which were verified by ex vivo measurements. Autoradiography confirmed focally increased uptake of Al 18 F-NOTA-Folate in the atherosclerotic plaques (plaque-to-normal vessel wall ratio 2.6±0.7, P &lt;0.0001). Competitive study with excess of unlabelled folate reduced Al 18 F-NOTA-Folate uptake in the aorta by app. 80% and thus verified the specificity of its binding. In the rabbit aorta, the PET/CT showed a strong focal in vivo uptake of Al 18 F-NOTA-Folate co-localizing with an atherosclerotic abdominal aorta with highest aorta-to-blood ratio of 6.0. For comparison, with 18 F-FDG the ratio was 2.4 in the same area. Conclusions: Al 18 F-NOTA-Folate, targeting FR-β, accumulates in macrophage-rich atherosclerotic plaques, which can be detected in vivo by PET/CT in experimental models of atherosclerosis. Further development of the tracer for imaging of patients with atherosclerosis is warranted.
IMMUNITY TO MALARIA
Authors: P. W. C.
Journal: Annals of Internal Medicine (1941)

Editorial1 July 1941IMMUNITY TO MALARIAP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-1-146 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThat human beings can acquire a considerable degree of resistance to malarial infection has been known for many years. It is a matter of common observation that native inhabitants of tropical regions in which malaria is continuously prevalent—the "hyperendemic" areas—acquire a resistance or at least a tolerance for the infection, so that they show no clinical symptoms of malaria although susceptible newcomers quickly become ill and often succumb to the disease. The conditions under which such immunity develops have been studied with particular care by British observers such as Thomson, Christophers, and James.1These studies have shown that practically everyone...1 ASHFORD MFor an excellent review of much of this work see: : The nature of immunity to malaria in its relationship to antimalarial therapy, Am. Jr. Trop. Med., 1936, xvi, 665-678. Google Scholar2 WILSON DB: Implications of malarial endemicity in East Africa, Trans. Roy. Soc. Trop. Med. and Hyg., 1938-39, xxxii, 435-446. Google Scholar3 MANWELL RD: Reciprocal immunity in the avain malarias, Am. Jr. Hyg., 1938, xxvii, 196-211. Google Scholar4 MULLIGANSINTON HWJA: Studies in immunity in malaria. Superinfection with various strains of monkey malarial parasites, Rec. Malaria Survey India, 1933, iii, 529. Google Scholar5 JAMES SP: Some general results of study of induced malaria in England, Trans. Roy. Soc. Trop. Med. and Hyg., 1931, xxiv, 477-538. CrossrefGoogle Scholar6 BOYD MF: On strains or races of the malarial parasites, Am. Jr. Trop. Med., 1940, xx, 69-80. CrossrefGoogle Scholar7 EATONCOGGESHALL MDLT: Complement fixation in human malaria with an antigen prepared from the monkey parasite, Plasmodium knowlesi , Jr. Exper. Med., 1939, lxix, 379-398. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1941Volume 15, Issue 1Page: 146-148KeywordsImmunityInfectious diseasesMalariaTropical diseases ePublished: 1 December 2008 Issue Published: 1 July 1941 PDF downloadLoading ...
To Subscribers.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Task Force 4: Appropriate Clinical Care and Issues of “Self-Referral”
Authors: James L. Ritchie, Michael J. Wolk, John W. Hirshfeld, Joseph V. Messer, Eric D. Peterson, Eric N. Prystowsky, Timothy J. Gardner, Harry R. Kimball, Richard L. Popp, Lynn Smaha, Sidney C. Smith, L. Samuel Wann
Journal: Circulation (2004)
Trends in biliary tract injuries from laparoscopic cholecystectomy RM Walsh, JM Henderson, DP Vogt, JT Mayes, S Grundfest-Broniatowski, and RE Hermann. The Cleveland Clinic Foundation, Department of General Surgery, Cleveland, Ohio
Journal: Hepatology (1995)

Whereas portal systemic shunts pose significantproblems in many patients, they have long been thought to have particular risks when undertaken in older cirrhotic patients, with devastating encephalopathy reportedly common in older patients undergoing nonselective shunt surgery. With advances in anesthesia management and perioperative monitoring and the advent of selective shunting, we postulated that both the operative and long-term outcomes might be improved. In this context, we reviewed our recent experience with selective shunts [distal splenorenal (DSRS) and small-diameter interposition portacaval grafts (IPCG)] in patients over the age of 60 years with variceal bleeding.Nineteen consecutive cirrhotic patients over 60years of age undergoing elective or urgent selective shunt surgery for variceal hemorrhage since 1986 were identified. Sixteen patients underwent DSRS, and 3 underwent IPCG. The etiologies of the cirrhosis were multiple, with 12 of 19 classified as Child's B or C disease. There were no operative deaths, and all but one patient returned home following the surgery. No patient has had recurrent bleeding or required further surgery for portal hypertension-related problems. Three of 19 developed encephalopathy, and 4 of 19 died of liver failure within 1 year of surgery. Of the 14 patients still alive and well (mean postoperative survival: 44 months, range: 4 to 74 months), all remain free of encephalopathy and live independently.Based on this experience, it would appear that one can anticipate satisfactory short- and long-term outcomes after selective shunt surgery in selected patients with variceal bleeding over the age of 60 years. These patients with portal hypertension should not, therefore, be rejected for shunt surgery based on age alone.
Accounting and Business Procedure for Hospitals.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practitioner Programs
Authors: Francesw MDrew
Journal: JAMA (1973)

<h3>To the</h3> DRosinski's "Education and Role of the Physician,"ring in the Oct 23, 1972, issue ofTJournal,ly anticipatesck from the medical profession in suggesting a new category of Medical Practitioner with a bachelor's degree who would provide primary care as a member of the health team after a specific four-year undergraduate curriculum. Although Dr. Rosinskilved in discussions of medical manpower, he seems never to have heard of Nurse Practitioner programs already in action at a number universities (Albany, University-North Carolina, University of Rochester, to name but a few). The courses he suggests for his "new" category already largely exist in baccalaureaterograms, and those portions that do not (differentialosis, for example) are increasinglyed, especially at those universities with Nurse Practitionerams. Ishare entirely with him the view that in a decade or so most primary care will be given by people with less than a medical degree, as well as the implication that current medical education overeducates for assumption of
Age-Related Macular Degeneration
Authors: Stuart L. Fine, Jeffrey W. Berger, Maureen G. Maguire, Allen C. Ho
Journal: New England Journal of Medicine (2000)

Age-related macular degeneration, a deterioration of the central portion of the retina, is the chief cause of severe and irreversible loss of vision in developed countries.1,2 There is no effective treatment for most patients with age-related macular degeneration, and many patients therefore resort to experimental treatments. Physicians must know how to counsel their patients about the limitations and risks of these experimental therapies. Fortunately, several clinical trials sponsored by both the National Eye Institute and the private sector are evaluating novel prophylactic and therapeutic interventions. In addition, there is much exciting, ongoing basic research, some of which may lead . . .
Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease
Authors: John Wilson, Hannah Cullup, Rohan Lourie, Yonghua Sheng, Anna Palkova, Kristen J. Radford, Anne M. Dickinson, Alison M. Rice, Derek N.J. Hart, David J. Munster
Journal: The Journal of Experimental Medicine (2009)
Debridement
Authors: D. H. Patey
Journal: BMJ (1944)

<b>Objective:</b> To ascertain clinical predictors of final diagnosis of spinal dural arteriovenous fistulas (SDAVF) in patients with myelopathy. <b>Background:</b> SDAVF are an uncommon but treatable cause of myelopathy. This study explores clinical factors which predict SDAVF in the setting of radiographic lesions concerning for demyelination. <b>Methods:</b> We performed a retrospective chart review of PACS imaging system for the term “spinal dural arteriovenous fistula” to obtain cases. Inclusion criteria included any confirmed case of SDAVF. We performed another retrospective chart review of PACS for the term “demyelinating” to serve as controls. Inclusion criteria included any demyelinating lesion in the spinal cord. Exclusion criteria included previous diagnosis of demyelinating lesion. The SDAVF group was compared with the demyelinating group across demographics, vascular risk factors, smoking history, spinal cord lesion level on MRI, and back pain symptoms using t-test or Chi-square analyses. Multivariate analysis was used to further evaluate if these factors had any predictive value. <b>Results:</b> SDAVF patients were significantly older (mean 65.5 vs. 39.2, p&lt;0.001), more likely to be male (80[percnt] vs 35.6[percnt], p&lt;0.001), more likely to have vascular risk factors (65[percnt] vs. 26[percnt], p=0.001), more likely to have back pain (50[percnt] vs. 18[percnt], p=0.004), less likely to have cervical lesions (25[percnt] vs. 69[percnt], p&lt;0.001), and more likely to have thoracic (80[percnt] vs 49[percnt], p=0.008) and lumbosacral lesions (40[percnt] vs. 3[percnt], p&lt;0.001). Multivariate analysis showed age (OR=1.14, 95[percnt] CI 1.06-1.22), back pain (OR=5.33, 95[percnt] CI 1.13-25.14) and lumbosacral lesions (OR11.20, 95[percnt] CI 1.31-95.98) predict SDAVF. Cervical lesions predict that patients are less likely to have SDAVF (OR=0.18, 95[percnt] CI 0.04-0.84). <b>Conclusions:</b> Patients are more likely to have SDAVF than a demyelinating lesion if they are male, present at an older age, with back pain, and with lumbosacral lesions, and less likely with cervical myelopathy. <b>Disclosure:</b> Dr. Tipirneni has nothing to disclose. Dr. Tipirneni has nothing to disclose. Dr. Atchaneeyasakul has nothing to disclose. Dr. Bleicher has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Covidien/evV3 as a consultant and Steering Committee Member.
Chronic Myeloid Leukemia Philadelphia Chromosome Positive (CML Ph+) with Imatinib (IM) Intolerance or Resistant Disease. Response to Thalidomide (TALI) Treatment. Preliminary Report of a Serial of Cases with Encouraging Results
Authors: Rafael Hurtado, Jose Pablo Vargas Viveros, Carrillo Muñoz Silvia, Judith Cruz-Velazquez, Myrna Candelaria, Eduardo Cervera
Journal: Blood (2012)
Arthur Conan Doyle's thesis on tabes dorsalis
Authors: A. E. Rodin
Journal: JAMA (1982)

Best known as a writer of detective fiction, Arthur Conan Doyle was formally trained as a physician and practiced medicine from 1881 to 1891. He wrote articles on several medical subjects as well as an extensive thesis on tabes dorsalis for an MD degree. The thesis is a comprehensive and well-written summation of the subject. Its literary qualities were as unique to scientific writing in his day as they would be today. (<i>JAMA</i>1982;247:646-650)