tbuckley/cabot-search huggingface dataset:
HOME RULE FOR LONDON
Authors: H. Elliot-Blake
Journal: BMJ (1909)

<h3>Abstract</h3> Cross-sectional imaging, such as computed tomography (CTA) scans, provide unparalleled visualization of aortic anatomy. However, despite the immense geometric and anatomic detail provided by CTA imaging, surgeons continue to interact with this data in a linear and dimensionally reduced feature space. Aortic pathologies such as aneurysms and dissections are clinically quantified using a single scalar: maximum aortic diameter. To date, not feature of aortic shape has reproducibly captured what surgeons often describe qualitatively when looking at CT scans or when in the operating room observing the physical anatomy. Shape along with size plays a central role in differentiating normal from diseased aortas. We defined a geometric feature space using tools of modern differential geometry that incorporate shape and size. We show that size can be parameterized by <i>ℓ</i>, the radial aortic extent commonly taken as aortic diameter. Size invariant shape is quantified by performing a Gauss map of local regions on the aortic surface and calculating the variance of the total integrated curvature (<i><b>δK</b></i>) across each aorta. While we do not inherently study aortic stability as it relates to clinical rupture in this paper, aortas appearing at high <b><i>δK</i></b> are clinically classified by size and qualitative appearance as high risk. It is therefor interesting to conjecture that divergence in the (<b><i>δK</i></b>, )-space is a sign of aortic topologic instability. Projection into (<b><i>δK</i></b>, )-space provides two independent variables that show a natural division of the data as it transitions from size to shape dominated behavior, an indictor of aortic fragility.
Reporting Bad News
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pravastatin reduces the high rate of atherothrombotic complications in coronary heart disease patients with intermittent claudication Andrew Tonkin, Adrienne Kirby, Paul Newman, David Hunt, Malcolm West, Harvey White, Norman Sharpe, Denis Friedlander, Bhuwan Singh, John Simes, For the LIPID Study investigators. National Heart Foundation of Australia, Melbourne, Australia, NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia
Journal: Journal of the American College of Cardiology (2001)
Treatment of postpartum hemolytic uremic syndrome with plasma exchange
Authors: C. D. Spencer
Journal: JAMA (1982)

POSTPARTUM hemolytic uremic syndrome (HUS) is a rare disease with a reported mortality of 61%.<sup>1</sup>Heparin and antiplatelet agents are of unproved benefit in the treatment of HUS.<sup>2,3</sup>Recently Remuzzi and co-workers<sup>4</sup>demonstrated reversal of hemolysis and thrombocytopenia within 48 hours after a single plasma exchange in two middle-aged women with severe hypertension and HUS. The present report describes the treatment of HUS in a postpartum patient with plasma exchange alone, documenting the promptness with which it reversed hemolysis and thrombocytopenia in this setting. <h3>Report of a Case</h3> A 23-year-old woman (gravida 4, para 2, abortus 1) was seen at another hospital in her 34th gestational week with acute abdominal pain. She was preeclamptic. Her hematocrit reading was 20% and platelet count was 113,000/cu mm. She received packed RBCs and 2 units of fresh-frozen plasma. Five hours after admission she was spontaneously delivered of a stillborn infant
BLOOD VISCOSITY AND BLOOD PRESSURE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FERDINAND VON HEBRA
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Haptoglobin electrophoresis
Authors: A. L. Louderback
Journal: JAMA (1968)

Haptoglobin is a serum glycoprotein whose name is derived from the Greek work<i>haptein</i>(to fix or seize) because it binds free, circulating hemoglobin to form a very stable complex. Haptoglobin is most probably synthesized in the liver<sup>1</sup>and, in complex with hemoglobin, is presumably removed from circulation by the reticuloendothelial system.<sup>2</sup>The haptoglobin level determines the renal threshold of hemoglobin. After the haptoglobin binding capacity is exceeded, free hemoglobin appears in the urine. In humans, three types of haptoglobin which occur in genetically controlled combinations are now recognized: type 1-1, with only one hemoglobin-binding fraction; type 2-2, with three to four hemoglobin-binding fractions; and type 2-1, with five to six hemoglobin-binding fractions, one of which has the same electrophoretic mobility as haptoglobin 1-1.<sup>3</sup>These correspond to three genotypes produced by a single pair of allelic genes. There are subtypes within group 2-1, and a fourth haptoglobin
Rhinitis and asthma
Authors: M. Kaliner
Journal: JAMA (1992)

ALTHOUGH both rhinitis and asthma occur without a recognized allergic mechanism, IgE-mediated inflammation is usually found in both diseases. It is estimated that 40 million Americans (nearly 25%) have asthma and other allergic diseases. Other figures compiled by the National Center for Health Statistics underscore the magnitude of this health burden.<sup>1</sup>In fact, allergic rhinitis accounts for more than 3% of all office visits.<sup>1</sup>The prevalence of the common allergic diseases<sup>2</sup>is shown in Table 3-1. <h3>ALLERGENS IN ALLERGIC DISEASES</h3> Inhalant allergens are most frequently involved in allergic respiratory diseases, such as allergic rhinitis and asthma. These antigens, which directly impact on the respiratory mucosa, are usually derived from natural organic sources, such as house dust, pollens, mold spores, and insect and animal emanations. Chemicals and irritants from the workplace have been increasingly recognized as a cause of rhinitis, asthma, or both. A few aeroallergens have been
MORE LOOSE THINKING BY EDDYITES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Idiopathic thrombocytopenic purpura in patients with histoplasmosis
Authors: J. O. Armitage
Journal: JAMA (1977)

THROMBOCYTOPENIC purpura has been reported secondary to a multiplicity of causes.<sup>1</sup>However, idiopathic thrombocytopenic purpura (ITP), in relation to infectious diseases other than viral illnesses, is unusual. We report two cases where ITP developed with the onset of histoplasmosis. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 41-year-old woman was referred to the University of Iowa Hospitals on July 3, 1970, with a two-week history of fevers, chills, headache, nonproductive cough, and a 7-kg weight loss. She had failed to respond to oral antibiotic therapy. She had been in good health prior to the onset of the aforementioned symptoms, and there was no antecedent history of easy bleeding, bruising, or hematologic abnormality. The patient appeared severely ill and was febrile. Neither lymphadenopathy nor hepatosplenomegaly was found. Pulmonary and cardiovascular examination results were unremarkable. Petechiae and ecchymoses were not observed. Initial laboratory studies included a WBC count of 7,400/cu mm, with 81%
Council and Committee Seats Available to Residents
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Program Indexes
Authors: Anderson As, Willis Wittpenn, Oiland Binder, Abbott Abelson, Aiello Friedlander, Bensinger Jones, Choromokos Katz, Chu Kaufman, Corn Koenig, Davis Laibson, Easterbrook Lamberts, Fernan Lemp, Fujikawa Marks, Goldbaum Martonyi, Hyman Mayer, Kaplan Mcculley, Lass Ostler, Lewis Ostler, Maumenee Pico, Morgan Polack, Newman Roberts, Pruett Salamon, Skalka Schanzlin, Wilson Smith, Gla Ocoma, Stu Iris, Del Priore, Lawton Troutman, Ke Jin, O Connor, Van Buskirk, Posters Scientific, Kincaid 45 Norris, Lense Contact, Bosniak Brindley, Honan Bullock Char, Coles Della, Rocca Choyce, Dresner Espy, Dryden Faye, Garber Faye, Gladstone Fonda, Hawes Gager, Iliff Ge, Katowitz Groden, Katowitz Gruber, Katzen Guyton, Katzen Halberg, Kohn Hartstein, Kopelman Holladay, Lemke Lippman, Leone Maltzman, Levine Mccannel, Levine Meshel, Linberg Michaels, Milder Michaels, Millett Moore, Neuhaus Phelps, Putterman Romayananda, Crawford Orcutt, Helveston Reifler, Hiles Rosenberg, Kare Sh, Keech Weiss, Saunders Koster, N Sprague, Lnforma Tional, Posters Haddad, B Chamberlain, Allen O'neill, Augsburger Parks, Barr Raab, Bloome Rabinowicz, Blumenkranz Reinecke, Boldrey Romano, Braunstein Rosenbaum, Brinkley Saunders, Bronson Saunders, Burton Sokol, Byer Von Noorden, Carr Von Noorden, Carr Wilson, Carroll Retina, Coleman Vitreous, Davis Davis Berman, Flach Berson, Blacharski Glaser, Supplement Program, Ernest 346 Michels, I Fenzl, P Kaufman, J Kearney, T Kearns, R Keates, R Keech, C Kelley, N Kelly
Journal: Ophthalmology (1986)
Efficacy tests ahead for antimetastatic agent
Authors: B. Merz
Journal: JAMA (1983)

An antimetastatic agent that appears to be free of adverse effects may be available to clinicians soon, according to Kenneth V. Honn, PhD, associate professor of radiology and radiation oncology, Wayne State University School of Medicine, Detroit. Honn told participants at a recent American Cancer Society seminar in San Diego that research into the effects of anticoagulants on migrant cancer cells has produced an agent, nafazatrom, that looks promising in phase I (safety) clinical trials. As Honn sees it, the critical event in metastasis is the stable attachment of a cancer cell to a blood vessel wall. He postulates that the tumor cell accomplishes this by first binding to host platelets, and then, coated with platelets, lodging in the microvasculature and adhering to the vascular endothelium. A protective thrombus may subsequently develop around the tumor cell, shielding it until it escapes into surrounding tissues, where it can proliferate. Honn and
Genetic Influences on Smoking: Candidate Genes
Authors: Mary Anne Rossing
Journal: Environmental Health Perspectives (1998)

Twin studies consistently indicate important genetic influences on multiple aspects of smoking behavior, including both initiation and cessation; however, knowledge regarding the role of specific genes is extremely limited. Habit-forming actions of nicotine appear to be triggered primarily at nicotinic receptors on the cell bodies of dopaminergic neurons in the mesolimbic "reward" system of the brain, a region implicated in addiction to other substances including cocaine, opiates, and alcohol. Important aspects of the dopaminergic pathway include synthesis of dopamine in dopaminergic neurons, release of dopamine by presynaptic neurons, receptor activation of postsynaptic neurons, dopamine re-uptake by presynaptic neurons, and metabolism of released dopamine. Research examining the role of allelic variation in genes involved in these functions is being actively pursued with respect to addictive behavior as well as personality traits and psycho- and neuropathologic conditions and has implications for smoking research. In addition, genetic differences in nicotinic receptors or nicotine metabolism might reasonably be hypothesized to play a role in smoking addiction. A role of dopaminergic or other genes in smoking cessation is of particular potential importance, as research in this area may lead to the identification of subgroups of individuals for whom pharmacologic cessation aids may be most effective.
Nephron, Basel
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Backache
Authors: N. Capener
Journal: BMJ (1965)

<i>APOL1</i> variants have been associated with renal phenotypes in blacks. To refine clinical outcomes and discover mechanisms of <i>APOL1</i>-associated kidney injury, we analyzed clinical and genomic datasets derived from 90 black subjects in the Nephrotic Syndrome Study Network (NEPTUNE), stratified by <i>APOL1</i> risk genotype. Ninety subjects with proteinuria ≥0.5 g/d were enrolled at first biopsy for primary nephrotic syndrome and followed. Clinical outcomes were determined, and renal histomorphometry and sequencing of Mendelian nephrotic syndrome genes were performed. <i>APOL1</i> variants were genotyped, and glomerular and tubulointerstitial transcriptomes from protocol renal biopsy cores were analyzed for differential and correlative gene expression. Analyses were performed under the recessive model (high-risk genotype defined by two risk alleles). <i>APOL1</i> high-risk genotype was significantly associated with a 17 ml/min per 1.73 m<sup>2</sup> lower eGFR and a 69% reduction in the probability of complete remission at any time, independent of histologic diagnosis. Neither <i>APOL1</i> risk group was enriched for Mendelian mutations. On renal biopsy, high-risk genotype was associated with increased fractional interstitial area, interstitial fibrosis, and tubular atrophy. Risk genotype was not associated with intrarenal <i>APOL1</i> mRNA expression levels. Differential expression analysis demonstrated an increased steady-state level of five genes associated with the high-risk genotype (<i>CXCL9</i>, <i>CXCL11</i>, and <i>UBD</i> in glomerulus; <i>SNOR14B</i> and <i>MUC13</i> in tubulointerstitium). <i>APOL1</i> tubulointerstitial coexpression analysis showed coexpression of <i>APOL1</i> mRNA levels with a group of intrarenal transcripts that together were associated with increased interstitial fibrosis and tubular atrophy. These data indicate the high-risk <i>APOL1</i> genotype confers renal risk across histopathologic diagnoses.
Prevalence of Selected Risk Factors for Chronic Disease and Injury Among American Indians and Alaska Natives—United States, 1995-1998
Journal: JAMA (2000)

INDIGENOUS WILD POLIOVIRUS WAS LAST isolated in China in 1994.On October 13, 1999, a case of acute flaccid paralysis (AFP) in a 16-month-old boy was reported to public health authorities in Xunhua Autonomous County, Haidong Prefecture, Qinghai Province, China.Following onset of paralysis on October 12, the boy was no longer able to stand or walk.Two stool samples, taken within 14 days of onset of paralysis, were analyzed in the Qinghai provincial laboratory and yielded poliovirus.The isolates were later differentiated as wild poliovirus type 1 at the National Poliovirus Laboratory in Beijing.Stool specimens from one of five children with whom the boy had contact yielded wild poliovirus type 1.This report describes this case of poliomyelitis and the public health response to the case in China.The case occurred among the Sala, a group of approximately 80,000 persons who live mainly in Xunhua Autonomous County, Qinghai, or in neighboring Gansu province.Many Sala are traders, and Sala men travel widely within Qinghai and to nearby provinces, including Gansu, Sichuan, and Xinjiang, and to Tibet as far south as the border with Nepal.The Sala have trade contacts in India, Pakistan, and Central Asia.Neither the case-patient nor immediate family members are reported to have traveled outside Xunhua County during the 2 months before paralysis onset.Despite intensive investigations, including retrospective record reviews in health-care facilities and active case
Friday Night
Authors: L. Jeffrey Purdy
Journal: JAMA (1986)

John strolled along Garey Avenue in South Pomona the same night the LA County Fair opened. In the distance he could hear the muffled sounds from the thousands present, an occasional scream of excitement. The smells of cotton candy and corn dogs, pigs and the workers on the midway, even beer and vomit in the dirt evoked a smile as he recalled all the times he had visited the fair with his parents when he was a kid. Crowds annoyed him now; he preferred walking alone at night. At night he could think over ways he could still change some things in his life. There had to be other streets for these night walks. He kicked a large piece of broken glass into the gutter near a pawn shop. His hands were stuffed deeply in his jeans pockets. His shoulders were shrugged and he walked slowly, watching his feet move.
O-006 FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as initial treatment for metastatic colorectal cancer (TRIBE study): updated survival results and final molecular subgroups analyses
Authors: C. Cremolini, F. Loupakis, C. Antoniotti, S. Lonardi, M. Ronzoni, A. Zaniboni, G. Tonini, G. Masi, S. Chiara, C. Carlomagno, L. Salvatore, M. Banzi, F.V. Negri, L. Marcucci, M. Schirripa, C. Barone, G. Fontanini, N. Borrelli, M. Giordano, E. Macerola, L. Boni, A. Falcone
Journal: Annals of Oncology (2015)