tbuckley/cabot-search huggingface dataset:
Correspondence
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCTAP A-171 Crossover from Radial to Ipsilateral Ulnar Artery: A Safe and Feasible Alternative in Complex Radial Artery Anatomy
Authors: Nagaraja Moorthy, Rajiv Ananthakrishna, Dattatreya PV, Rangaraj Ramalingam, C.N. Manjunath
Journal: Journal of the American College of Cardiology (2017)
RESULTS OF ANTITYPHOID VACCINATION IN THE WORLD'S ARMIES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Randomized Trial of Methylprednisolone and Chlorambucil in Idiopathic Membranous Nephropathy
Authors: Claudio Ponticelli, Pietro Zucchelli, Patrizia Passerini, Leonardo Cagnoli, Bruno Cesana, Claudio Pozzi, Sonia Pasquali, Enrico Imbasciati, Claudio Grassi, Bruno Redaelli, Mauro Sasdelli, Francesco Locatelli
Journal: New England Journal of Medicine (1989)

We conducted a controlled trial to investigate the long-term effects of treatment with methylprednisolone and chlorambucil in patients with idiopathic membranous nephropathy. We have previously reported that after a mean of 31 months, treated patients did better. We now report the results of a longer follow-up. Eighty-one patients with proteinuria (≥3.5 g per day) and biopsy-proved membranous nephropathy were randomly assigned to receive either supportive therapy alone or a six-month course of corticosteroids alternated with chlorambucil (0.2 mg per kilogram of body weight per day) every other month. Methylprednisolone was first given intravenously in three pulses (1 g per day) and was then given orally (0.4 mg per kilogram per day) for 27 days. The patients were followed for 2 to 11 years (median, 5). Two patients in the control group and one in the treatment group died. At the last follow-up visit, 9 of 39 patients assigned to the control group (23 percent) and 28 of 42 patients assigned to the treatment group (67 percent) did not have the nephrotic syndrome. At five years there were more remissions of the nephrotic syndrome in treated patients than in controls (22 of 30 vs. 10 of 25; P = 0.026). Compared with base-line values, the mean reciprocal of the plasma creatinine level declined significantly in the control group (33 percent; P = 0.0002) but not in the treatment group (6 percent; P not significant). Plasma creatinine increased by 50 percent or more in 19 controls (49 percent) and in 4 treated patients (10 percent). We conclude that a six-month course of methylprednisolone and chlorambucil can bring about sustained remission of the nephrotic syndrome and help to preserve renal function in patients with idiopathic membranous nephropathy. (N Engl J Med 1989; 320:8–13.)
A small portable digital-analogue device for electrocardiographic screening
Authors: W. J. Walker
Journal: JAMA (1967)

The electrocardiogram is probably the most effective screening device in the United States for the recognizing of latent heart disease in middleaged persons.<sup>1,2</sup>The increased effectiveness of antihypertensive therapy, as well as a clearer definition of the risk factors in coronary atherosclerosis, suggests that earlier recognition of patients with chronic heart disease would afford a fruitful area for constructive, preventive medicine. The expense of taking and mounting the ECG, as well as the time lag in obtaining expert interpretation, makes the use of routine electrocardiography impractical in many insurance, employment screening, and "check-up" examinations. A device able to select persons with electrocardiographic abnormalities at the time of the original examination would allow these individuals to be identified and scheduled for more extensive cardiovascular evaluation without delay and without compromising physician time with the majority who are not cardiac-disease suspects. <h3>Method</h3> The present study was designed to test the ability
Perspectives in Cancer Chemoprevention
Authors: Gary D. Stoner, Mark A. Morse, Gary J. Kelloff
Journal: Environmental Health Perspectives (1997)

Cancer chemoprevention can be defined as prevention of cancer by the administration of one or more chemical entities, either as individual drugs or as naturally occurring constituents of the diet.Based largely on the time period that chemopreventive agents exhibit activity in animal models of carcinogenesis, they can be classified as inhibitors of carcinogen formation, blocking agents, and suppressing agents.The majority of compounds that inhibit the formation of carcinogens prevent the formation of nitrosamines from secondary amines and nitrite in an acidic environment.Blocking agents are inhibitors of tumor initiation, while suppressing agents are inhibitors of tumor promotion/progression.Many well-characterized chemopreventive agents act at one or more steps in both tumor initiation and promotion/progression.The objective of this paper is to provide a general discussion of the mechanisms through which chemopreventive agents inhibit carcinogenesis.Examples of agents that act through these mechanisms are given; however, a complete listing of effective chemopreventive agents is not possible within the context of this paper.At the conclusion is a brief discussion of future prospects in cancer chemoprevention and obstacles to overcome.
Metabolism II
Authors: J. Pinilla, T. Phang, M. Baetz, S. Selvan, S. Hattori, F. Turani, D. F. Colella, E. Zupancich, M. Dauri, G. M. Actis Dato, M. Falco, A. F. Sabato, M. Planas, J. R. Masclads, I. Porta, R. Iglesias, B. Benejo, F. J. de Latorre, B. Schneeweiss, J. Pammer, K. Ratheiser, Ch. Madl, L. Kramer, A. Kranz, M. Fischer, G. Grimm, K. Lenz, P. F. Laterre, G. Hanique, Th. Dugernier, M. Andresen, A. Dougnac, J. Roeseler, M. S. Reynaert, R. D. Griffiths, P. A. Maclennan, T. Helliwell, R. R. Macmillan
Journal: Intensive Care Medicine (1992)
THE RENEWAL OF THE ANTIVIVISECTION AGITATION.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebrovascular Insufficiency
Authors: Alan T. Marty
Journal: JAMA (1983)

"Carotid" derives from a Greek word meaning "stupefy"; compression of these arteries has long been known to induce sleepiness. Today, carotid endarterectomy is the most common peripheral vascular operation performed in America. Even so, the subject of cerebrovascular insufficiency continues to confound us. Perhaps most bewildering is whether to operate in the face of an acute neurological deficit. Timely surgery can reverse the evanescent uncoupling between blood flow and regional metabolism sometimes seen after a stroke. In selected patients with stroke-in-evolution, surgery is here proved safe and helpful. Vascular surgeons and neurologists are, thus, cautiously changing their minds about who else to operate on. Indeed the buzzword of this book is "change": change in our concepts of carotid atherogenesis, why ulcers form on lesions, the pendulation in presumed etiological importance between stenosis v embolization, and modifications in diagnostic and therapeutic maneuvers are all magnificently reviewed. While the book aims primarily
Abstract 3526: Incorporation of unique molecular identifiers (UMIs) into unique dual sample indexing (UDI) improves the accuracy of quantitative next generation sequencing
Authors: Pingfang Liu, Keerthana Krishnan, Camille X. Devoe, Bradley W. Langhorst, Eileen Dimalanta, Theodore B. Davis
Journal: Cancer Research (2019)

Abstract Accurate analysis of quantitative NGS data is critical for low frequency variant detection, identification of differentially expressed transcripts, and correct diagnosis and patient care in a clinical NGS setting. Two major factors affecting sequencing accuracy are 1) PCR duplication arising from amplification of library molecules; and 2) errors introduced during library preparation and actual sequencing on the flow cell. Standard practice for identification and removal of PCR duplicates relies on aligning reads to the same genomic coordinates. However, this approach can not differentiate between PCR duplicates and reads originating from unique molecules with identical ends. The most effective method for error correction is Duplex Sequencing, which utilizes UMIs to tag both strands of each individual DNA duplex followed by building consensus sequences. Unfortunately, this approach is labor intensive and cost-prohibitive for complex genomes and large target panels. Therefore, a simple and reliable approach for duplicate removal and error correction would greatly facilitate the wider adoption of NGS technology for diagnostics and clinical applications. In this study, we incorporate UMIs into UDI systems and assess the effect on the accuracy of quantitative sequencing assays. We first study the effectiveness of various computational methods to account for UMIs and remove base-calling errors introduced during sequencing. We then analyze the utility of UMIs for 1) unique and low abundance transcript identification and accurate transcript quantification; and 2) error correction in low frequency variant detection in genomic sequencing from both high quality cell line DNA and low quality FFPE DNA. In addition, we demonstrate that combining unique dual sample indexing with UMI molecular barcoding further improves data analysis accuracy, especially on patterned flow cells. Our approach involves a simple new UMI-containing UDI adaptor design that can also be applied to other sequencing methods and platforms. Citation Format: Pingfang Liu, Keerthana Krishnan, Camille X. Devoe, Bradley W. Langhorst, Eileen Dimalanta, Theodore B. Davis. Incorporation of unique molecular identifiers (UMIs) into unique dual sample indexing (UDI) improves the accuracy of quantitative next generation sequencing [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3526.
Proliferation-associated differences in the spatial and temporal expression of gap junction genes in rat liver*1
Authors: M NEVEU
Journal: Hepatology (1995)

After a 70% partial hepatectomy (PH), the steady-state levels of Connexin (Cx)32, Cx26, and Cx43 messenger RNA (mRNA) transcripts each displayed unique patterns of temporal expression. Within 1 hour after surgical resection, increased expression of all three Cx mRNAs was observed. Subsequently, the level of Cx32 mRNA transcripts transiently decreased to a nadir at 12 hours. Comparisons of the spatial changes with previously reported hepatocyte proliferation kinetics induced by PH demonstrated that hepatocytes before S-phase “remodel” their GJs. Within 1 to 5 hours post-PH, midzonal hepatocytes exhibited diffuse membrane staining different from the normal punctate distribution. Subsequently, midzonal hepatocytes expressed colocalized punctate Cx32 and Cx26 immunostaining. Because the changes occurred in midzonal hepatocytes before 24 hours post-PH, near the peak of hepatocyte DNA synthesis, these findings indicate that Cx26 is enhanced in hepatocytes before the onset of S-phase. In contrast to the restricted expression of Cx43 in Glisson's capsule in adult liver, Cx43 protein and mRNA were enhanced specifically in proliferating bile duct and perisinusoidal cells post-PH. PH performed during continuous administration of 2-acetylaminofluorene (AAF) prevented changes in Cx32 and Cx26 staining observed in the absence of AAF. Proliferating oval cells were found to express diffuse Cx43 immunoreactivity. On day 11 post-PH and AAF, basophilic hepatocytes displayed both punctate Cx32 and Cx26 staining, whereas bile ducts and perisinusoidal cells expressed Cx43. These findings indicate that alterations in Cx32 and Cx26 expression occur rapidly in hepatocytes stimulated to proliferate and that several nonparenchymal liver cell types upregulate Cx43 expression when induced to proliferate. Differentiation of oval cells into basophilic hepatocytes resulted in their expression of Cx32 and Cx26.
Mesothelioma in Man and Experimental Animals
Authors: M. Kannerstein, J. Churg
Journal: Environmental Health Perspectives (1980)

Asbestos has been established as the cause of most cases of diffuse malignant mesothelioma occurring in the industrialized world. The morphology of mesothelioma may be complex, and the employment of chemical, histochemical and ultrastructural studies are often helpful in identification. Diagnostic difficulties may to some degree blur the extent of its prevalence and reliance on exposure history may not reveal its association with asbestos. Reference panels can be useful in assessing the former and analysis of lung tissue asbestos content may help to clarify the latter, especially in the low dose range. Electron microscopy may prove to be of assistance in this respect, possibly with particular attention to the peripheral areas of the lung. Animal experimentation has supported epidemiologic conclusions and revealed the phenomenon of fiber carcinogenesis. The morphology of mesothelioma in experimental animals is very similar to that in humans, including ultrastructural and biochemical features.
Reply to Maxwell.V. Meng’s Letter to the Editor re: H. Baumert et al. The Use of Polymer (Hem-o-lok) Clips for Management of the Renal Hilum During Laparoscopic Nephrectomy. Eur Urol 2006;49:816–9 and P.L. Steinberg et al. re: H. Baumert et al. The Use of Polymer (Hem-o-lok) Clips for Management of the Renal Hilum During Laparoscopic Nephrectomy. Eur Urol 2006;49:816–9. Eur Urol 2007;51:572–3
Authors: Andrew Ballaro, Hervé Baumert
Journal: European Urology (2006)
Pseudotumor cerebri associated with danazol withdrawal
Authors: M. Fanous
Journal: JAMA (1991)

<h3>In Reply.</h3> —I would like to thank Dr Wright for sharing his data. His incredulity with respect to the epidemiologic necropsy is understandable. It often strikes people as being counterintuitive that necropsy data could be useful for epidemiologic purposes. With appropriate methodological safeguards to minimize sources of bias, however, the epidemiologic necropsy is proving to be a very useful technique. Thus, instead of refuting the results of the KUMC study, the results from the Broward County Medical Examiner's Office support the epidemiologic necropsy. In discussions with my colleagues in both Cleveland, Ohio, and New Haven, Conn, we have considered the use of the coroner's population as a good test of the technique. Since the majority of these individuals come to necropsy without knowledge of a given disease, they would serve as an excellent population in which to test the epidemiologic necropsy. When appropriate adjustments for age, gender, and race are
SOCIETY PROCEEDINGS.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OFFICIAL REPORTS FOR 1928
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MYOCARDITIS AND ITS MANAGEMENT
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The relation between transverse conduction capabilities and the anatomy of the crista terminalis in patients with paroxysmal atrial fibrillation and flutter: Analysis with intracardiac echocardiography Koichi Mizumaki, Akira Fujiki, Hidehiko Nagasawa, Kenji Sakurai, Kunihiro Nishida, Masao Sakabe, Hiroshi Inoue. The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
Journal: Journal of the American College of Cardiology (2001)