tbuckley/cabot-search huggingface dataset:
Validation of a patient‐reported outcomes symptom measure for patients with nontransfusion‐dependent thalassemia (NTDT‐PRO<sup>©</sup>)
Authors: Ali Taher, Maria Domenica Cappellini, Vip Viprakasit, Pranee Sutcharitchan, Dalia Mahmoud, Abderrahmane Laadem, Anzalee Khan, Chad Gwaltney, Gale Harding, Kenneth Attie, Xiaosha Zhang, Jun Zou, Joseph Pariseau, X. Henry Hu, Antonis Kattamis
Journal: American Journal of Hematology (2018)

Abstract This study demonstrates the quantitative characteristics of the first patient‐reported outcome (PRO) tool developed for patients with nontransfusion‐dependent β‐thalassemia (NTDT), the NTDT‐PRO © . A multicenter validation study was performed over 24 weeks, involving 48 patients from Italy, Lebanon, Greece, and Thailand. Most patients were female (68.8%), with a median age of 34.5 years (range, 18‐52); 66.7% were diagnosed with β‐thalassemia intermedia, and median time since diagnosis was 22 years (range, 0‐43). The NTDT‐PRO comprises 6 items across 2 domains (Tiredness/Weakness and Shortness of Breath [SoB]), and was valid and reliable, with good consistency. At baseline, most patients reported symptoms as present via the NTDT‐PRO, and were highly compliant, ≥90% completing the NTDT‐PRO tool. In a pairwise correlation analysis, all items were positively correlated. Correlations between NTDT‐PRO and existing tools—36‐Item Short Form Health Survey version 2 (SF‐36v2) and Functional Assessment of Cancer Therapy‐Anemia (FACT‐An)—were assessed at weeks 1, 3, and 12; robust correlations were seen between SoB and SF‐36v2‐Vitality ( r s = −0.53), and between SoB and Fact‐An‐Fatigue Experience ( r s = −0.66) at week 1. Internal consistency was high for both Tiredness/Weakness (Cronbach alpha, 0.91) and SoB (Spearman‐Brown coefficient, 0.78); intraclass correlation coefficients were high (Tiredness/Weakness, 0.88 and 0.97; SoB, 0.92 and 0.98), demonstrating stability. Further studies are required to fully support the validity of this tool, this study demonstrated the usefulness of the NTDT‐PRO in the clinical setting and for longitudinal clinical research, particularly in trials where patient health‐related quality of life is expected to change.
This Month's Highlights
Journal: Journal of the American Society of Nephrology (2007)

### Dysregulation of Laminins Plays a Role in Alport Disease In Alport disease, the glomerular basement membranes contain aberrant laminins in addition to the abnormal collagenous network that results from mutations in the genes encoding the α3, α4, or α5 chains of type IV collagen. In a mouse
Amitriptyline Poisoning
Authors: Gerald M. Fendrick
Journal: New England Journal of Medicine (1962)

THE list of therapeutic agents employed in the field of psychopharmacology is an imposing one. There have been reports of toxic reactions to many of these drugs, and, in 1959, the Boston Poison Information Center received 106 telephone calls regarding their ingestion either accidentally or with suicidal intentions. Among medications only acetylsalicylic acid was responsible for more calls.At the time of this writing 4 cases of poisoning related to the ingestion of a recently introduced antidepressant, amitriptyline, have been reported.1 One of them involved a fifteen-month-old girl who died after the ingestion of approximately 50 25-mg. tablets (1250 mg.). . . .
Abnormal blood chemistry values in Hodgkin's disease. Lack of correlation with staging of disease
Authors: P. H. Levine
Journal: JAMA (1972)

Nine of 26patients with Hodgkin's disease had persistent abnormalities of serum alkaline phosphatase or transaminase levels, or sulfobromophthalein retention, and were studied in prospective fashion for evidence of liver or bone disease. Only one case of true stage IV disease could be documented. The serum abnormalities disappeared following radiotherapy in most cases. Abnormal blood chemistry values in Hodgkin's disease should not be assumed to reflect stage IVdisease.
Abdominal Aortography
Authors: Owings W. Kincaid, George D. Davis
Journal: New England Journal of Medicine (1958)

Renal ArteriographyUntil about 1952, almost all reports on aortography encountered in the literature were concerned with its use in urologic diagnosis, particularly in the differential diagnosis of renal tumors and cysts.The value of aortography in differentiating renal cysts and neoplasms depends on the differences in their vascular patterns, renal cysts being completely avascular, and the majority of renal neoplasms showing increased vascularity described as "puddling" or "tumor staining."11,31, 69 70 71 Some authors believe that the differentiation of tumor and cyst can be made by aortographic means with considerable accuracy. Evans,72 in a large series of cases, has found this differentiation . . .
Semiparametric Modeling of Age at Achieving Developmental Milestones after Prenatal Exposure to Methylmercury in the Seychelles Child Development Study
Authors: Catherine D. Axtell, Gary J. Myers, Philip W. Davidson, Anna L. Choi, Elsa Cernichiari, Jean Sloane-Reeves, Conrad Shamlaye, Christopher Cox, Thomas W. Clarkson
Journal: Environmental Health Perspectives (1998)

The kidney is affected by many chemicals. Some of the chemicals may even contribute to end-stage renal disease and thus contribute considerably to health care costs. Because of the large functional reserve of the kidney, which masks signs of dysfunction, early diagnosis of renal disease is often difficult. Although numerous studies aimed at understanding the mechanisms underlying chemicals and drugs that target various renal cell types have delivered enough understanding for a reasonable risk assessment, there is still an urgent need to better understand the mechanisms leading to renal cell injury and organ dysfunction. The increasing use of in vitro techniques using isolated renal cells, nephron fragments, or cell cultures derived from specific renal cell types has improved our insight into the molecular mechanisms involved in nephrotoxicity. A short overview is given on the various in vitro systems currently used to clarify mechanistic aspects leading to sublethal or lethal injury of the functionally most important nephron epithelial cells derived from various species. Whereas freshly isolated cells and nephron fragments appear to represent a sufficient basis to study acute effects (hours) of nephrotoxins, e.g., on cell metabolism, primary cultures of these cells are more appropriate to study long-term effects. In contrast to isolated cells and fragments, however, primary cultures tend to first lose several of their in vivo metabolic properties during culture, and second to have only a limited life span (days to weeks). Moreover, establishing such primary cultures is a time-consuming and laborious procedure. For that reason many studies have been carried out on renal cell lines, which are easy to cultivate in large quantities and which have an unlimited life span. Unfortunately, none of the lines display a state of differentiation comparable to that of freshly isolated cells or their primary cultures. Most often they lack expression of key functions (e.g., gluconeogenesis or organic anion transport) of their in vivo correspondents. Therefore, the use of cell lines for assessment of nephrotoxic mechanisms will be limited to those functions the lines express. Upcoming molecular biology approaches such as the transduction of immortalizing genes into primary cultures and the utilization of cells from transgenic animals may in the near future result in the availability of highly differentiated renal cells with markedly extended life spans and near in vivo characteristics that may facilitate the use of renal cell culture for routine screening of nephrotoxins.
Editorial Board
Authors: Bruce Thiers, Dirk Elston, Detra Davis, Jack Lesher, Nikki Levin, Mary Spellman, Jeffrey Weinberg, Dermatologic Surgery, Clifford Perlis, Julie Prendiville, Frcpc Dermatopathology, John Maize, Social Media, Emily Altman, Robert Dellavalle, J Smith, Editors Emeritus, Richard Dobson, Jeffrey Bernhard, Calvin Mccall, Brett Sloan, James Solomon, Stephen Tyring, George Hruza, Pediatric Dermatology, Kelly Cordoro, Dermatopathology Carlson, Tammie Ferringer, Cyberdermatology Consultant, Daniel Siegel, Clara Kim, Bryan Anderson, Salvador Arias-Santiago, Trisha Beute, John Binhlam, Diana Bolotin, Markus Braun-Falco, Nooshin Brinster, Patrick Carrington, Zoe Draelos, Nananamibia Duffy, Laura Ferris, David Fivenson, Joel Gelfand, Camille Introcaso, Nathaniel Jellinek, Jonathan Kantor, Matthew Kanzler, Kevin Kia, Kenneth Linden, Jason Lott, Omar Lupi
Journal: Journal of the American Academy of Dermatology (2016)
Abstract 16807: Role of Rotor Activation Within the Pulmonary Vein as the Driving Sources for Atrial Fibrillation: Three-dimensional Analysis using a Non-contact Mapping System
Authors: Hiroshige Yamabe, Hisanori Kanazawa, Tadashi Hoshiyama, Miwa Ito, Shozo Kaneko, Hisao Ogawa
Journal: Circulation (2015)

Background: It has been suggested rotor which is located within the pulmonary vein (PV) acted as the driving sources of atrial fibrillation (AF). However, it has never been confirmed whether or not the rotor exists within PV in human. Objectives: We analyzed the activation sequence within the PV during AF and examined how the PV acted as the driving sources of AF. Methods: Selective endocardial mapping of left superior PV (LSPV) was performed during AF in 11 paroxysmal AF patients using a non-contact mapping system (EnSite 3000). Presence of rotor activation was defined when the circular activation around the functional block line once completed its whole reentrant activation. We analyzed the relation between the pivoting activation and the rotor activation. To define the preferable site of rotor and pivoting activation, we also analyzed the relation between the location of rotor and pivoting activation and region of the complex fractionated electrogram (CFE) recording site. Results: Rotor activation was observed with a mean number of 4.6±3.6 times/sec. CFE was observed at the roof (n=5), ridge (n=11) and carina (n=7) of the proximal half of LSPV with a mean area of 9.1±3.4 cm2. The number of rotor activation observed at the CFE area was significantly higher than that at the non-CFE area (4.1±3.9 vs. 0.7±1.2 times/sec, p=0.025). Total frequency of pivoting activation was 37.0±14.7 times/sec. Pivoting activation involved in the rotor activation was significantly lower than that not involved in the rotor activation (8.8±8.1 vs. 27.7±15.8 times/sec, p=0.0116). Regarding the CFE area, pivoting activation involved in the rotor activation was also significantly lower than that not involved in the rotor activation (8.4±8.2 vs. 24.1±12.0 times/sec, p=0.0105). However, there was no difference between the frequencies of pivoting activation with and without rotor activation in the non-CFE area (1.0±2.0 vs. 3.6±6.1 times/sec, p=NS). Conclusions: Rotor activation was observed at the proximal portion of the LSPV coincided with the location of CFE area. However, most of pivoting activation was not involved in the rotor activation. These suggest that AF was driven by the other meandering propagation associated with frequent non-stable pivoting activation over the CFE area.
Open, comminuted fracture of the distal humerus
Authors: O. E. Aufranc
Journal: JAMA (1968)

Dr. Mohinder Mital: An 81-year-old widow arrived in the emergency ward of the Massachusetts General Hospital with a chief complaint of pain in the right arm. She described a fall down one flight of stairs approximately one hour before admission. There was no loss of consciousness preceding or following the injury. Her past medical history included fractures of the mid shafts of the right radius and ulna nine years earlier. These had been treated by open reduction with Rush rod fixation of the ulna and iliac crest bone graft fixation of the radius, held in position by four stainless steel screws. A clinic note one year after this injury described no symptoms and a full range of flexion and extension of the elbow with 30° pronation and 50° supination in the forearm. Physical examination revealed an alert, elderly, obese woman. She was complaining bitterly of pain in the right arm.
Handicapped children.
Journal: BMJ (1971)

40 mg sulphadoxine administered fortnightly was completely successful in suppressing seasonal hyperendemic malaria in the children over a period of 6 months, but that pyrime- thamine alone in the standard dosage of 25 mg weekly failed to do so in some cases.Moreover 11 out of 12 controls receiving no suppressives developed malaria during the period of observation.No untoward side effects were en- countered.A similar trial using sulphadoxine or dapsone with pyrimethamine in weekly dosage among school children in Nigeria has also been successful.2Standard antimalarial regimens for prophylaxis and sup- pression in adults include proguanil 100 mg daily, or chloro- quine 300 mg (base), pyrimethamine 25 mg, amodiaquine 400 mg (base), or chlorproguanil 20 mg weekly.For most purposes these will probably long continue to be used, but the regimens advocated by Laing and A. 0. Lucas will almost certainly find increasing application.
More Robust Effort Needed to Reduce HIV Risk Behavior, Increase Testing
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunoblastic lymphadenopathy presenting as pulmonary interstitial fibrosis
Authors: R. Asher
Journal: JAMA (1977)

IMMUNOBLASTIC lymphadenopathy commonly presents with fever, chills, night sweats, and malaise.<sup>1</sup>The usual physical findings are lymphadenopathy, hepatosplenomegaly, and a maculopapular erythematous rash. Laboratory features include positive Coombs test, mild to moderate hemolytic anemia, mild leukocytosis, and polyclonal hypergammaglobulinemia. Frequently there is a history of previous drug exposure. In addition to the usual presenting features, our patient had bilateral pleural effusions and interstitial fibrosis with nodularity. <h3>Report of a Case</h3> A 78-year-old woman was admitted to a referral hospital with a four-month history of fever, chills, night sweats, and a nonproductive cough. Chest x-ray films showed a diffuse infiltrate and bilateral effusions. Treatment with ampicillin trihydrate resulted in moderate improvement. Prednisone treatment was added because of the patient's long history of arthritis. One month later, exertional dyspnea, two-pillow orthopnea, paroxysmal nocturnal dyspnea, and nocturia developed. Bilateral effusions were again present, and a pleural fluid complement was low. A presumptive
Timolol-Induced Bronchospasm
Authors: Robert Mandelkorn
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The article "Timolol-Induced Bronchospasm in Asthmatic Bronchitis" by Schoene et al (1980; 245:1460) added further clinical evidence that timolol maleate, a β-adrenergic receptor blocking agent, should be used with caution in patients with chronic obstructive pulmonary disease with an asthmatic component. Their recommendation to correlate the patient's clinical condition after the administration of timolol drops with spirometry readings is feasible, but we think the quality of the data could be enhanced by considering the following points. The control group was not exactly comparable to the timolol group. The protocol did not suggest that periodic readings of forced expiratory volume in 1 s (FEV<sub>1</sub>) were taken after the initial 30-minute interval vs 15, 30, 60, 90, and 120 minutes in the timolol group. Therefore, factors such as fatigue in performing the spirometry were not controlled. The data could have been easily enhanced by making the investigation a double-blind
Preoperative fluorouracil (FU)-based chemoradiation with and without weekly oxaliplatin in locally advanced rectal cancer: Pathologic response analysis of the Studio Terapia Adiuvante Retto (STAR)-01 randomized phase III trial
Authors: C. Aschele, C. Pinto, S. Cordio, G. Rosati, A. Tagliagambe, S. Artale, P. Rosetti, S. Lonardi, L. Boni, L. Cionini
Journal: Journal of Clinical Oncology (2009)

CRA4008 Background: Oxaliplatin (OXA) enhances the efficacy of FU-based chemotherapy in colon cancer. This randomized phase III trial investigated the effect of adding OXA to preoperative (preop) FU-based pelvic chemoradiation (CRT) in patients (pts) with locally-advanced rectal cancer. Methods: Eligibility required a resectable, biopsy-proven rectal adenocarcinoma within 12 cm from the anal verge with radiological evidence of perirectal fat or lymphnode involvement. Randomization was between infused FU (225 mg/msq/day) concomitant to external-beam pelvic radiation (50.4 Gy in 28 daily fractions) (arm A) or the same regimen + weekly OXA (60 mg/msq × 6) (Arm B). Surgery was scheduled 6–8 weeks after completing CRT. Overall survival was the primary endpoint. A protocol-planned analysis of local tumor response to preop treatment (secondary end-point) is the object of this report. Results: 747 pts from 41 Italian centers were randomized between 12/2003 and 8/2008 (arm A/B: 379/368). Pretreatment characteristics in arm A/B: median age 63/62 years; male:female 2:1; median distance from anal verge 6 cm; T4 16/14%, N+ 63/65%. Overall grade 3–4 toxicity rates on treated pts (mainly diarrhoea) were 8% and 24% (arm A/B, p&lt;0.001). 96/90% of pts (arm A/B) received &gt; 90% of the planned RT. 82% of Arm B pts had &gt; 5 oxa courses. 358/342 pts (arm A/B) had surgery at a median of 52/53 days from the end of CRT, 14 pts in each arm were not operated (progression 8, death 5, other/unknown 15) and surgery data are not yet available for 19 pts. Pathologic response data analyzed on the randomized population are reported in the table . Conclusions: The addition of weekly OXA to standard FU-based preop CRT significantly increases toxicity without affecting local tumor response. The reduced pathologic M+ rate suggests a potential effect on distant micrometastases. Longer follow-up is needed to assess the impact on efficacy endpoints. [Table: see text] No significant financial relationships to disclose.
Choice of a Medical School
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease
Authors: S. Akilesh
Journal: Journal of Clinical Investigation (2004)

The MHC class I family–like Fc receptor, FcRn, is normally responsible for extending the life span of serum IgG Ab’s, but whether this molecule contributes to autoimmune pathogenesis remains speculative. To determine directly whether this function contributes to humoral autoimmune disease, we examined whether a deficiency in the FcRn heavy chain influences autoimmune arthritis in the K/BxN mouse model. FcRn deficiency conferred either partial or complete protection in the arthritogenic serum transfer and the more aggressive genetically determined K/BxN autoimmune arthritis models. The protective effects of an FcRn deficiency could be overridden with excessive amounts of pathogenic IgG Ab’s. The therapeutic saturation of FcRn by high-dose intravenous IgG (IVIg) also ameliorated arthritis, directly implicating FcRn blockade as a significant mechanism of IVIg’s anti-inflammatory action. The results suggest that FcRn is a potential therapeutic target that links the initiation and effector phases of humoral autoimmune disease.
<i>ERJ</i>Podcast February 2017: ERS technical standards for the single-breath determination of nitric oxide uptake in the lung
Journal: European Respiratory Journal (2017)

As part of the February issue, the European Respiratory Journal presents the latest in its series of podcasts. Chief editor Marc Humbert discusses the new ERS task force document, on single-breath determination of nitric oxide uptake in the lung, with Prof. Gerald S. Zavorsky from the Georgia State University, USA.
HPV Vaccine
Authors: Joan Stephenson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal