Selecting Patients with Colorectal Cancer To Test for Genetic Abnormalities
Journal: Annals of Internal Medicine (2001)

Summaries for Patients16 October 2001Selecting Patients with Colorectal Cancer To Test for Genetic AbnormalitiesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-8_Part_1-200110160-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Colorectal cancer affects the colon (large intestine) or rectum. An inherited cancer syndrome called hereditary nonpolyposis colorectal cancer (HNPCC) is the cause of colorectal cancer in some patients. People with HNPCC have a higher than usual risk for colorectal and several other types of cancer. In HNPCC, colorectal tumors have a DNA abnormality (DNA is the substance that makes up genes) called microsatellite instability. In addition, people with HNPCC frequently have abnormalities (mutations) in two genes known as MLH1 and MSH2. Patients with an MLH1 or MSH2 mutation ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Bethesda Guidelines: Relation to Microsatellite Instability and MLH1 Promoter Methylation in Patients with Colorectal Cancer.” It is in the 16 October 2001 issue of Annals of Internal Medicine (volume 135, pages 566-576). The authors are J Raedle, J Trojan, A Brieger, N Weber, D Schäfer, G Plotz, E Staib-Sebler, S Kriener, M Lorenz, and S Zeuzem.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBethesda Guidelines: Relation to Microsatellite Instability and MLH1 Promoter Methylation in Patients with Colorectal Cancer Jochen Raedle , Jörg Trojan , Angela Brieger , Nicole Weber , Dieter Schäfer , Guido Plotz , Elsbeth Staib-Sebler , Susanne Kriener , Mathias Lorenz , and Stefan Zeuzem Bethesda Guidelines: Relation to Microsatellite Instability and MLH1 Promoter Methylation in Patients with Colorectal Cancer Jochen Raedle , Jörg Trojan , Angela Brieger , Nicole Weber , Dieter Schäfer , Guido Plotz , Elsbeth Staib-Sebler , Susanne Kriener , Mathias Lorenz , and Stefan Zeuzem Metrics 16 October 2001Volume 135, Issue 8_Part_1Page: I-47KeywordsColorectal cancerDNAGenetic testingHereditary nonpolyposis colorectal cancerLarge intestineMethylationMutationPatientsRectal cancerRectum ePublished: 16 October 2001 Issue Published: 16 October 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...