tbuckley/cabot-search huggingface dataset:
Various clinical outcomes in patients with esophageal or gastroesophageal junction (E-GEJ) adenocarcinoma undergoing trimodality therapy: Prognostic implications.
Authors: Akihiro Suzuki, Lianchun Xiao, Takashi Taketa, Kazuki Sudo, Mariela A. Blum, Ritsuko Komaki, Zhongxing X. Liao, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Wayne Lewis Hofstetter, Stephen Swisher, Jaffer A. Ajani
Journal: Journal of Clinical Oncology (2013)

120 Background: Preoperative chemoradiation (trimodality therapy) has the strongest evidence in trimodality-eligible patients with E-GEJ adenocarcinoma. Pathological complete response (pathCR) and clinical complete response (clinCR) are favorable prognostic factors. We hypothesized that pathCR is associated with best prognosis. Methods: Patients with E-GEJ adenocarcinoma undergoing trimodality therapy were identified from the prospectively maintained databases at our institution. Multiple statistical methods were used. Results: For 314 esophageal cancer patients, the median follow-up time was 44.0 months (95% CI; 34.2-50.9). 107 of 314 patients died at this analysis. 80 patients (25.5%) had a pathCR. 160 patients (51.0%) had a clinCR prior to surgery but did not have pathCR. The remaining 74 (23.6%) had &lt;pathCR and &lt;clinCR. Median OS were: not achieved in pathCR patients, 82.8 months (95% CI; 63.9, NA) in clinCR patients and 27. 6 months (95% CI; 19.4, NA) &lt;pathCR/&lt;clinCR (p&lt;0.001). The median recurrence-free survival (RFS) were: 79.6 months (95% CI; 37.4, NA) in pathCR patients, 67.4 months (95% CI; 31.8, NA) in clinCR patients and 13.5 months (95% CI; 10.4, 21.4) in &lt;pathCR/&lt;clinCR (p&lt;0.001). In multivariate analysis, no lymph node metastasis (p&lt;0.001), not poorly differentiated adenocarcinoma (p=0.002) and pathCR (p=0.02), and cCR (p&lt;0.001) were independent prognosticators of OS and RFS. Conclusions: pathCR and clinCR are independent prognosticators (pathCR producing the best results) and may be helpful in devising new therapeutic and surveillance strategies.
MEASLES AND WHOOPING COUGH DANGEROUS DISEASES.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POSTOPERATIVE ILEUS.
Authors: FRANK MARTIN
Journal: JAMA (1907)

In the list of complications and sequelæ following a surgical operation involving the opening of the abdomen, perhaps no single one is more to be dreaded or more urgently demands early recognition and prompt relief than intestinal obstruction, and occurring as a postoperative ileus it is, in fact, one of the most serious and dangerous, as well as one of the most fatal surgical conditions, the surgeon is called on to face. It frequently is insidious in its manifestations, but more often rapid in its progress and liable to sudden and progressive changes which steadily but surely put the patient in a condition of extreme peril. One naturally has a feeling of dread when he has to face a case of postoperative ileus, because so often surgical relief is not sought until the patient is exhausted or until necrosis of the bowel wall has taken place, and associated either with
MORE ABOUT SMALLPOX
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Epidemiology
Authors: Mary-Claire King, Geraldine M. Lee, Nancy B. Spinner, Glenys Thomson, Margaret R. Wrensch
Journal: Annual Review of Public Health (1984)

In recent decades, there has been remarkable growth in scientific research examining the multiple ways in which racism can adversely affect health. This interest has been driven in part by the striking persistence of racial/ethnic inequities in health and ...Read More
De Novo Deletion 17p13.1 Chronic Lymphocytic Leukemia Shows Significant Clinical Heterogeneity: The MD Anderson/Mayo Clinic Experience.
Authors: Constantine S. Tam, Tait D. Shanafelt, William G. Wierda, Lynne V Abruzzo, Daniel L. Van Dyke, Susan Lerner, Alice Lynn, Neil E. Kay, Michael J Keating
Journal: Blood (2008)
Drug-induced systemic lupus erythematosus. Primidone as a possible cause
Authors: G. K. Ahuja
Journal: JAMA (1966)

SYSTEMIC lupus erythematosus (SLE) is a disease of connective tissue involving multiple systems with protean manifestations. Abnormal immunological reactions have been found more frequently in SLE than in any other disease. The pathogenetic significance and the mechanism by which these immunological reactions develop remain obscure. The role of drug hypersensitivity continues to evoke interest. Many drugs have been associated with the onset or exacerbation of SLE. Hydralazine (Apresoline) hydrochloride, given to patients for the treatment of hypertension, was the first drug reported to our knowledge to produce a reversible lupus-like syndrome. Other drugs reported to give rise to this syndrome are penicillin, phenylbutazone, sulfadiazine, and the anticonvulsants—sodium diphenylhydantoin (Dilantin Sodium), mephenytoin (Mesantoin), and trimethadione (Tridione). To our knowledge, no case of SLE has been described following administration of primidone (Mysoline). This report describes observations in a patient with long-standing seizure disorder in whom SLE developed after a period of administration
Sulfadiazine
Authors: Robert G. Petersdorf
Journal: JAMA (1984)

<h3>Brief History of the Sulfonamides</h3> Although sulfanilamide was discovered by a German. graduate student named Gelmo as early as 1908, the therapeutic potential of the sulfonamides was not appreciated until the demonstration by Domagk that Protonsil protected mice from streptococcal infection. The first patient in whom Protonsil was shown to be effective was an infant with staphylococcal sepsis who was treated in 1933. From that point on, a variety of sulfonamides was described in rapid succession; articles on sulfanilamide, sulfapyridine, sulfathiazole, and sulfamethylthiazole flooded the literature. The accompanying article,<sup>1</sup>although not the first clinical description of the sulfonamide drugs, was the most complete dealing with sulfadiazine, an agent that is still with us almost 45 years and many thousands of patients later. <h3>Content of the Accompanying Article</h3> In brief, Finland and colleagues describe the animal data available for sulfadiazine and compare it with sulfapyridine and sulfathiazole in experimental infections. They
THE MINNEAPOLIS SESSION
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hormone Levels Incorrect
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Figure
Authors: Gery Guy, Zahava Berkowitz, Meg Watson
Journal: JAMA Dermatology (2017)

Christina Lee Chung, MD; Kumar S. Nadhan, BS; Christine M. Shaver, MD; Lauren M. Ogrich, MD; Mark Abdelmalek, MD; Carrie Ann Cusack, MD; Gregory E. Malat, PharmD; Ellen N. Pritchett, MD, MPH; Alden Doyle, MD, MPH
Accuracy of Gram's Stain in Identifying Pneumococci in Sputum
Authors: Michael F. Rein, Jack M. Gwaltney, William M. O'Brien, Robert H. Jennings, Gerald L. Mandell
Journal: JAMA (1978)

We prospectively examined the accuracy of Gram-stained sputum for identifying pneumococci in 42 patients with community-acquired pneumonia. We considered the Gram's stain positive if a preponderant flora or more than ten Gram-positive lancet-shaped diplococci were seen per oil immersion (×1,000) field. These criteria were met in 18 (62%) of 29 specimens that actually contained pneumococci as determined by a positive quellung reaction, or culture on plates or in mice. The Gram's stain was negative in 11 of 13 specimens that did not contain pneumococci. Of the 20 specimens yielding positive Gram's stains, 18 contained pneumococci. A positive Gramstained smear of sputum strongly suggests the presence of pneumococci, but will miss 38% of specimens containing pneumococci. Deviation from these criteria substantially reduces the overall accuracy of the test. (<i>JAMA</i>239:2671-2673, 1978)
Massachusetts Medical Society
Authors: Robert W. Buck, John Figgis Jewett
Journal: New England Journal of Medicine (1961)

WILLIAM H. SMITH, M.D., 1869–1960Dr. William H. Smith, physician, diagnostician and a "master in the art of teaching clinical medicine," died at the Hill Crest Nursing Home in Newton on December 1, 1960, in his ninety-second year. On the staff of Harvard Medical School for thirty years, and associated with the Massachusetts General Hospital for forty-one, he was universally known to decades of medical students, to doctors old and young, and to most of his friends and some of his patients as Big Bill Smith.He was born in Fall River, on September 10, 1869, the son of Iram . . .
Román-Gómez J, Cordeu L, Agirre X, Jiménez-Velasco A, San José-Eneriz E, Garate L, Calasanz MJ, Heiniger A, Torres A, Prosper F. Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia. Blood. 2007;109(8):3462–3469.
Journal: Blood (2012)
The validity of gestational age estimation by menstrual dating in term, preterm, and postterm gestations
Authors: M. S. Kramer
Journal: JAMA (1988)

Despite recognition that estimation of gestational age (GA) based on maternal recollection of the last normal menstrual period (LNMP) is fraught with error, it is not generally appreciated that the magnitude and direction of this error vary as a function of the LNMP estimate. Early second-trimester (16 to 18 weeks) ultrasound determinations of the fetal biparietal diameter were used as the "gold standard" to test the validity of LNMP-based GA estimates in 11 045 women. The large majority of deliveries occurring at or near term showed LNMP estimates that were valid within plus or minus seven days of the ultrasound estimate. As the LNMP GA deviated progressively toward earlier or later GAs, however, the discrepancies became quite marked, especially for postterm dates. The positive predictive values of the LNMP GA estimates decreased dramatically from term (.949) to preterm (.775) to postterm (.119) deliveries. These systematic errors in menstrual GA estimates have profound implications for unnecessary induction, dysfunctional labor and cesarean section, and resultant neonatal and maternal morbidity. (<i>JAMA</i>1988;260:3306-3308)
Nesidioblastosis in familial endocrine adenomatosis
Authors: J. E. Vance
Journal: JAMA (1969)

Symptomatic and asymptomatic members of a family with multiple endocrine adenomatosis (MEA) (pancreatic islet, parathyroid, and adrenal cortex) were studied. Of the six subjects studied representing three generations, all had excessive secretion of insulin, three showed excessive plasma glucagon responses to oral administration of dextrose, and four had elevated plasma gastrin levels. This evidence of islet hyperactivity suggests the following: (1) A genetic defect resulted in proliferation of the primordial cell of the islands of Langerhans, a condition termed nesidioblastosis. (2) Neoplastic islet cells have the capacity to secrete insulin, glucagon, and/or gastrinlike peptides. (3) The variable involvement of other endocrine glands in the familial MEA syndrome may be secondary to chronic hypersecretion of one or more of the islet hormones.
Illinois State Medical Society.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer
Authors: Karen M. Albert, Jonathan D. Cheng
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SCALOP-2: A multi-centre randomised study of induction chemotherapy followed by capecitabine (+/- nelfinavir) with high or standard dose radiotherapy for locally advanced non-metastatic pancreatic cancer
Authors: Pradeep Virdee, Rachel Shaw, Victoria Strauss, Claire Hamill, Christopher Hurt, Sarah Gwynne, Pippa Corrie, John Bridgewater, Philip Parsons, Bethan Tranter, David Sebag-Montefiore, Kwun-ye Chu, Ganesh Radhakrishna, Maria Hawkins, Eric O'Neill, Susan Campbell, Sharon Love, Tim Maughan, Somnath Mukherjee
Journal: Annals of Oncology (2017)
Posttranslational events involved in griseofulvin-induced keratin cytoskeleton alterations
Authors: H Salmhofer
Journal: Hepatology (1994)

Alcoholic hepatitis is a disease associated with profound alterations of the hepatocytic intermediate filament cytoskeleton. Similar cytoskeletal alterations can be induced in mice with prolonged feeding of the fungistatic drug griseofulvin. Murine hepatocytic intermediate filaments are composed of equimolar amounts of keratin polypeptides A (type II) and D (type I). Griseofulvin intoxication of mice leads to diminution, derangement and even loss of the cytoplasmic keratin meshwork and formation of keratin-containing cytoplasmic inclusions, termed Mallorybodies. To study protein alterations leading to disturbance of keratin filament architecture, soluble keratin polypeptides and keratin filaments were purified from griseofulvin-damaged and control mouse livers. In griseofulvin-damaged livers, more acidic isoforms occurred in soluble keratin D, whereas the corresponding filaments had a polypeptide composition similar to that in controls. In vivo [32P]orthophosphate incorporation revealed that the shift of isoelectric forms toward more acidic spots was due to hyperphosphorylation of keratin D. The nature of the kinase(s) involved has yet to be elucidated. In addition, rapid proteolysis only of soluble keratin A was detected in vitro, and there is evidence for increased proteolysis in griseofulvin damage in vivo. The enzyme involved has features of a calpain-type protease. Posttranslational modifications play a substantial role in the disturbance of keratin intermediate filament homeostasis in vivo. (HEPATOLOGY 1994;20:731–740).
Les manifestations tardives de l'encéphalite épidémique.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CAPILLARY PERMEABILITY
Authors: F P CHINARD, L B FLEXNER
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal