tbuckley/cabot-search huggingface dataset:
Journal of Surgical Research, Philadelphia
Journal: JAMA (1967)

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COLUMBUS MEDICAL COLLEGE.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II/III study of Circulating tumOr DNA as a predictive BiomaRker in Adjuvant chemotherapy in patients with stage II colon cancer: NRG-GI005 (COBRA).
Authors: Van K. Morris, Greg Yothers, Scott Kopetz, Samuel A. Jacobs, Peter C. Lucas, Atif Iqbal, Patrick M Boland, Dustin A. Deming, Aaron James Scott, Howard John Lim, Norman Wolmark, Thomas J. George
Journal: Journal of Clinical Oncology (2021)

TPS3622 Background: There are currently no validated predictive biomarkers for stage II resected colon cancer (CC) after adjuvant chemotherapy. However, circulating tumor DNA (ctDNA) that is shed into the bloodstream represents a highly specific and sensitive approach for identifying microscopic or residual tumor cells. For patients (pts) with CC, the detection of ctDNA is associated with persistent disease after resection and may outperform traditional clinical and pathological features as a prognostic factor to assess risk for recurrence. We hypothesize that for pts whose stage II colon cancer has been resected and who have no traditional high-risk features, a positive ctDNA status may identify those who will benefit from adjuvant chemotherapy. Methods: In this prospective phase II/III clinical trial, pts (N = 1,408) with resected stage II CC without traditional high-risk features and whom the evaluating oncologist deems suitable for no adjuvant chemotherapy will be randomized 1:1 into 2 arms: standard-of-care/observation (Arm A), or prospective testing for ctDNA (Arm B). Postoperative blood will be analyzed for ctDNA with the GuardantHealth LUNAR panel, covering CC-relevant mutations and CC-specific methylation profiling. Pts in Arm B with ctDNA detected will be treated with 6 months of adjuvant (FOLFOX) chemotherapy. For all pts in Arm A, ctDNA status will be analyzed retrospectively at the time of endpoint analysis. The primary endpoints are clearance of ctDNA with adjuvant chemotherapy (phase II) and recurrence-free survival (RFS) for “ctDNA-detected” pts treated with or without adjuvant chemotherapy (phase III). Secondary endpoints will include time-to-event outcomes (OS, RFS, TTR) by ctDNA marker status and treatment, prevalence of detectable ctDNA in stage II CC, and rates of compliance with assigned intervention. Archived normal and matched tumor and blood samples will be collected for exploratory correlative research. The trial is actively accruing towards the phase II endpoint in North America. NCT#: 04068103. Support: U10-CA-180868, -180822; UG1CA-189867; GuardantHealth. Clinical trial information: NCT04068103.
The LUMLEIAN LECTURES on the PRINCIPLES which GOVERN TREATMENT in DISEASES and DISORDERS of the HEART: Delivered before the Royal College of Physicians of London, March, 1898
Authors: R. D. Powell
Journal: BMJ (1898)

EXERCISES have been reduced to a system in three grades : massage, the resistance exercises, or their equivalent in the mechanical methods introduced by Zander of Stockholm in x872,1 and others, and the graduated walking exercises of
Professionalism at its worst
Authors: J. S. Todd
Journal: JAMA (1991)

There is no human endeavor or organization in which perfection is achieved even when it is assiduously sought. More than most, the medical profession, because of its unique role and the consequences of base behavior, has traditionally striven to instill in its practitioners a strong sense of duty and professionalism, but it would be foolhardy to assume that all physicians are ethical, honest, or competent. It is always easy to spotlight anecdotal cases of deviant behavior: good news doesn't sell newspapers! So, we are bombarded with accounts of gross incompetence, greed, and fraud against both patients and institutions. Attempts to quantify the extent of such behavior, although frequently attempted by extrapolation, are nonetheless fraught with so many difficulties that they probably cannot be successful. Obviously, the medical profession would like to assume that the numbers are minimal. That assumption, however, begs the question. If physicians are
The role of viruses in the etiology of cancer and leukemia
Authors: L. Gross
Journal: JAMA (1974)

This paper describes the development of the concept of "vertical transmission" of oncogenic viruses from one generation to another; the introduction of newborn mice for bioassay of oncogenic viruses; the discovery of the viral etiology of mouse leukemia and the isolation of the mouse leukemia virus; the clarification of the epidemiology of mouse leukemia on the basis of experimental demonstration that the mouse leukemia virus is transmitted from one generation to another directly through the embryos; the demonstration that radiation-induced leukemia in mice is caused by a virus; and the fortuitous isolation of a previously unknown and unsuspected oncogenic virus, the polyoma virus in mice. (<i>JAMA</i>230:1029-1032, 1974)
Mechanisms of Oncogene Cooperation: Activation and Inactivation of a Growth Antagonist
Authors: Michelle M. Ragozzino, Alan Kuo, James DeGregori, Nancy Kohl, H. Earl Ruley
Journal: Environmental Health Perspectives (1991)

Gene transfer experiments have defined limitations with regard to the ability of individual oncogenes to transform cultured cells to a tumorigenic state. The stable transformation of REF52 cells by either the ras or sis oncogenes requires the continuous expression of a second collaborating oncogene, such as adenovirus-5 E1A or SV40 large T-antigen. Our studies suggest that the function of the nuclear collaborators is to antagonize dominant growth controls which limit the ability of REF52 cells to proliferate in response to mitogenic stimuli.
A New Agent for the Treatment of Candidal Vaginitis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Naturally Occurring Insecticides
Authors: S. B. Soloway
Journal: Environmental Health Perspectives (1976)

Naturally occurring insecticides are abundant and varied in their effects, though but a few are articles of commerce. Even for these, pyrethrum, nicotine, rotenone, hellebore, ryania, and sabadilla, there is a paucity of information on mammalian toxicology and environmental effects. In general, these materials are characterized favorably by low acute toxicity and ready dissipation in nature. Unfavorable aspects of natural insecticides are the contained mixture of active and inactive components and the low active ingredient content on a crop yield basis pointing to a high unit cost. Natural insecticides can serve additionally as leads to unnatural mimics, of which the commercially successful synthetic pyrethroids are prime examples. The chemical nature, relationship of insecticidal activity to chemical structure, occurrence, production, and utilization, registered uses, metabolism, and insect and mammalian toxicity are reviewed.
Ruminations
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Whatever happened to the "old-time" infections
Authors: L. Weinstein
Journal: JAMA (1974)

REMARKABLE changes in the incidence and clinical features of some of the "old-time" infections have occurred over the past 25 to 30 years. Some of these have obviously been attributable to advances in prevention and treatment. For others, however, there are currently no discernible reasons for the alterations in their natural history. Although these changes have been taking place in all areas of our country, as well as in other developed parts of the world, this has not been the case in newly developing countries. The purpose of this article is to discuss this phenomenon, using data for incidence and personal experiences in Massachusetts since these reflect, in all probability, the situation in all areas of the United States. <h3>Varicella, Measles, and Poliomyelitis</h3> Varicella, measles, and poliomyelitis were very common in Massachusetts between 1945 and 1950. The total numbers of cases reported were 177, 761, 270, 675, and 10,181, respectively.
A Manual of Instruction in the Principles of Prompt Aid to Injured, including a Chapter on Hygiene and the Drill Regulations for the Hospital Corps for the U. S. A. Designed for Military and Civil use
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1962)

ANY QUESTIONS ?MEIJORNAL reducing the subsequent caries incidence by about 30%, especially in children.The present evidence is not generally regarded as conclusive.Fluorides can be administered in the form of sodium fluoride tablets, which for children are usually dissolved in water, milk, or fruit juices.For children above 3 years of age it has been advocated that the dosage should be 1 mg.a day of fluoride (2.2 mg. as sodium fluoride).Below this age the dosage should be reduced, and for babies 0.25 mg. a day, given through the feeding-bottle, is probably acceptable.A large survey2 has shown that this method of fluoride administration reduces caries incidence in children by about 20%, but there are grounds for believing' that when the administration is begun veTy early a greater beneficial effect occurs, and is similar to that produced by fluoridation of the water supplies-i.e., about 60-70% reduction.This method of fluoride administration can be recommended both for children of responsible and educated parents and for preg- nant women in areas with water supplies containing under 0.3 p.p.m. of fluoride.
CLINICAL LECTURES ON SURGERY NOW IN COURSE OF DELIVERY AT QUEEN'S COLLEGE, BIRMINGHAM
Authors: L. Parker
Journal: BMJ (1855)

Gza'TLEMEN,-I conceive it to be admitted, without ques- tion, that it is justifiable and proper to puncture the blad- der for the discharge of its contents, when its distension by ie has arrived at such an extent as to become unbear- able to the patient, when rupture of the bladder appears imminient from its over distension, and when discharge of urine from the urethra, and the introduction of instruments 'by this passage is impossible; and when other means, such as bleeding, the warm bath, opiates, chloroform, and other remedies, have been tried and failed.Four modes of opening the bladder have been proposed, and perfor6ied by surgeons at different times for this pur- pose. 1.Through the perinaum; the incision made pretty
THE RESORPTIVE POWERS OF THE PLEURA.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Voice Building and Tone Placing. Showing a new method of relieving injured vocal cords by tone exercises.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathogenesis and Prognosis of Prematurity
Authors: Mark Abramowicz, Edward H. Kass
Journal: New England Journal of Medicine (1966)

DURING the past century a variety of factors have come together to reduce infant mortality and therefore to increase mean life expectancy in industrialized societies. As environmental factors such as infection and disturbances of nutrition have become less prominent causes of death and disability in the newborn infant, the relative role of factors less affected by environmental control has increased. Prematurity is the most frequently recurring factor now involved in infant death and morbidity. As such it has become the largest single problem in contemporary pediatrics and obstetrics, as well as one of the major public-health problems of the present . . .
The highly profitable but unethical business of publishing medical research
Authors: Richard Smith
Journal: Journal of the Royal Society of Medicine (2006)

Richard Smith was editor of the BMJ and chief executive of the BMJ Publishing Group for 13 years. In his last year at the journal he retreated to a 15th century palazzo in Venice to write a book. The book will be published by RSM Press [ http://www.rsmpress.co.uk ], and this is the 6th in the series published in the JRSM.
Falls and femoral fractures.
Journal: BMJ (1978)

Hence we can ask the same important question as in the case of cell-mediated immunity: do healthy people with warts differ from the rest of the population in their ability to form antibodies ?One hint that they do comes from the finding that patients with warts may have a higher prevalence of autoantibodies-for example, to smooth muscle'5-than do controls.The questions flow on.Grubby and trivial warts may still be-but boring no longer.They are turning into a valuable model for studying man's response to tumours and to viral infections.
Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease
Authors: Alon Monsonego, Victor Zota, Arnon Karni, Jeffery I. Krieger, Amit Bar-Or, Gal Bitan, Andrew E. Budson, Reisa Sperling, Dennis J. Selkoe, Howard L. Weiner
Journal: Journal of Clinical Investigation (2003)

Alzheimer disease (AD) is characterized by the progressive deposition of the 42-residue amyloid β protein (Aβ) in brain regions serving memory and cognition. In animal models of AD, immunization with Aβ results in the clearance of Aβ deposits from the brain. However, a trial of vaccination with synthetic human Aβ1–42 in AD resulted in the development of meningoencephalitis in some patients. We measured cellular immune responses to Aβ in middle-aged and elderly healthy subjects and in patients with AD. A significantly higher proportion of healthy elderly subjects and patients with AD had strong Aβ-reactive T cell responses than occurred in middle-aged adults. The immunodominant Aβ epitopes in humans resided in amino acids 16–33. Epitope mapping enabled the identification of MHC/T cell receptor (TCR) contact residues. The occurrence of intrinsic T cell reactivity to the self-antigen Aβ in humans has implications for the design of Aβ vaccines, may itself be linked to AD susceptibility and course, and appears to be associated with the aging process.
RELIEF FROM RAGWEED
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sir Eardley Holland.
Authors: Eardley Holland, West Dean, Lancelot Eardley, W Lancelot 'holland, Eardley-Wilmot He
Journal: BMJ (1967)

Hay Wriginfon with first-class honours in medicine in 1905.He took his Fellowship of the Royal College of Surgeons in the same year, and in 1907 proceeded M.D., and was awarded the gold medal for midwifery and diseases of women.The Fellowship of the Royal College of Physicians came later, in 1920, and that of the Royal College of Obstetricians and Gynaecologists on its foundation in 1929.After holding early