tbuckley/cabot-search huggingface dataset:
Muscle Spasm and Degeneration in Intrathoracic Inflammation... and Light Touch Palpation.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Williams Hematology
Authors: Joseph M. Baron
Journal: JAMA (1995)

The fifth edition of<i>Williams Hematology</i>is a comprehensive textbook, which covers clinical aspects, basic science, and laboratory testing in this rapidly evolving field. A distinguished group of 95 experts has contributed the 210 chapters. Introductory chapters discuss clinical assessment of patients, examination of blood and bone marrow, and hematology of the newborn and the aged. There follows an extensive review of subjects in molecular hematology, including aspects of molecular biology, cytogenetics, and immunology pertinent to an understanding of modern hematology. Considerable attention is given to such therapeutic areas as pharmacology of antineoplastic drugs, use of cytokines, marrow transplantation, pain management, and the potential role of gene therapy in hematology. The classic hematologic disorders are then presented by system in concise monographs. There is expanded coverage of hemostasis and thrombosis and disorders of the immune system. A more comprehensive section on transfusion medicine topics is particularly useful. The traditional appendix
The Emigré Physician in America, 1941
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
L'endoscopie oeso-gastro-duodénale (E.O.G.D.) en France en 2005: résultats d'une enquête prospective nationale de la Société Française d'Endoscopie Digestive (SFED)
Authors: JM Canard, JP Arpurt, C Boustière, J Boyer, J Cassigneul, PA Dalbies, J Escourrou, G Gay, R Laugier, JC Letard, B Napoléon, L Palazzo, T Ponchon, B Richard-Molard, D Sautereau, G Tucat, B Vedrenne
Journal: Endoscopy (2007)

Le but de ce travail a été de décrire et de quantifier prospectivement l'ensemble des E.O.G.D. Réalisées en France et leur évolution depuis 1998
FOLDING CHAIR FOR SPINAL PUNCTURE
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pargyline Hydrochloride
Authors: J. S. Munro
Journal: BMJ (1964)

MEDIBCRTISOHNALthat the changes in urinary-oestrogens excre- tion after oophorectomy or adrenalectomy cannot be related to clinical benefit.6A possible conclusion is, therefore, that the benefit that follows oophorectomy or adrenalectomy in some patients with breast cancer is due not so much to removal of oestrogen as to the consequent liberation of gonadotrophins that follows such ablation therapy.In other words breast cancer in the younger woman may not be so much "oestrogen dependent" as "pituitary dependent."'There is, of course, other evidence that points to the same conclusion, but I hesitate to repeat this evidence in a letter.I would add only that my suggestion should lead logically to a trial of human pituitary gonadotrophin administration in patients with breast cancer failing to respond to castration.A similar trial was suggested in the treatment of cases showing a low gonadotrophin excretion after adrenalectomy.8The absence of reports of such trials in the literature to date reflects the difficulty of procuring adequate supplies of human pituitary gonadotrophin for thera- peutic trial, but I hope that this will be remedied in the near future.-Iam, etc.,
Opium
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Melioidosis
Authors: Everett B. Cooper
Journal: JAMA (1967)

Because of the return of a large number of persons, both military and civilian, from Southeast Asia, knowledge of melioidosis, endemic to that area, is of great importance. Through February 1967, 35 cases have been diagnosed in USA troops from that area, with eight fatalities. (Nine fatalities were reported by the Office of the Surgeon General, but one fatality included on the basis of clinical diagnosis proved, on autopsy, not to have been due to melioidosis.) Melioidosis is a disease of man and animals caused by a gram-negative motile bacillus,<i>Pseudomonas pseudomallei</i>. It is most commonly recognized as an acute pneumonia, but the clinical picture is variable, with a spectrum which includes asymptomatic infections manifested only by a positive serological reaction, asymptomatic pulmonary infiltration, acute toxic pneumonitis, and overwhelming fatal septicemia. Localized extrapulmonary forms may occur in any organ of the body. The disease may present several years after an
IBD and colorectal
Authors: Blanohi Porro
Journal: Gut (1996)

Since the relabtionship between H.pylon infection and NSAID-related pec ulcers remains unclear we have evaluated prospecvy in a consecutive series of 278 arthritic patients rceiving chronic NSAIDs the prevalence of peptic ulcer as well as the efect of H.pylorl eradication on the healing and recurrence of gstric and duodenal ulcer found.One hundred pepfic uicers (59 gastic ulcers, 39 duodenad ulcers and 2 gastric ulcers concomiant with a duodenal ulcer) wer diagnosed by gastr-scopy.Most of these ucers (70%) were associatd with H.pylori inhfeion (diagnosed by histology and rapid urease test).This frequency of infecion was significantiy infeior (p = 0.01) to that found in 178 patients with minor gastduodenal lesions (erosions or hyperemia) or normal endoscopic finding (49%).According to their H.pylori status, ulcer paents we randomized to receive one of the following acute beat s: H.pyo eaive ulcers received orneprazole 20 mg bid for 4-8 weeks, wherea H.pylori-posfiive ulcer were treated with omperazole 20 mg bid plus amoxycillin 1 9 bid (the latter for the first two wzeks) or omeprazole alone for 4-8 wks whilst continuing NSAID therapy.Endoscopic healing rates for gastric and duodenal ulcers in the thre different groups were similar both at 4 and 8 weks.H.pylori eradication did not influence healing, which occurred in 14120 (70%) of edicated patients, compared to 14/17 (82%) of pati with persistent infection.Sixty-one patients with healed ulcer w endoscop cally followed- up for six months after stopping antiulcer therapy while continuing NSAIDs.Cumultive recurrence rates at 6 months did not statistically differ among the three different groups (27% in H.pylon-ngative, 46% in H.pybri-poitive and 31% in those eradicated during the acute phase), aithough a numerical trend in favour of a higher recurrence rate in infected patients was evident.These findings show that H.pyloui eradication does not confere any significant advantage on the healing of NSAID-related gastric and duodenal ulces in long-term NSAID-users.It remains to be estblished with certainty whether eradication may be helpful to reduce recurrence in a specific subset of NSAID-ssociated ulcers.Conclusion: This preliminary study is the first to report estimations of [Ca2-], in isolated human colonic crypts, and may provide the methodology to study the role of [Ca2"] in diseased states of the humani colon. AIS
Anaesthesia in War Time
Authors: R. R. Macintosh, F. B. Pratt
Journal: BMJ (1939)

<h3>BACKGROUND AND PURPOSE:</h3> To our knowledge, no reproducible animal model of a giant bifurcation type aneurysm has been described. It was our aim to develop a 1-stage and reproducible model of a venous pouch giant aneurysm in canines. <h3>MATERIALS AND METHODS:</h3> Nine canines were involved. Bilateral CCAs were exposed. The left CCA was divided and its distal segment was swung to the right side. Using the right CCA and the distal segment of the left CCA, either a bifurcation or a terminal arterial structure was constructed. Bilateral external jugular veins were also exposed. A 30-mm vein segment was harvested from each side. Each vein graft was split and unfolded to make 2 venous sheets. These sheets were then joined top-to-bottom so as to form a single cylinder in such a way that original adventitial side of the venous sheets was on the exterior surface. In 2 instances, pieces of polytetrafluoroethylene were employed along with the venous sheets. The combined vein graft was then incorporated into the arterial anastomosis. Lastly, the top of the venous pouch was closed. No medications for anticoagulant or antiplatelet were used throughout the study period. Follow-up imaging studies were performed. <h3>RESULTS:</h3> It took 2.5 hours on average for 2 operators to create an aneurysm. Eight of the 9 aneurysms were patent at follow-up. The cause of the spontaneous thrombosis was unclear despite autopsy. All the aneurysms had a maximum diameter &gt;20 mm. <h3>CONCLUSIONS:</h3> We demonstrated and illustrated a 1-stage and reproducible procedure to create a model of a venous pouch bifurcation giant aneurysm in canines.
Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma
Journal: New England Journal of Medicine (2015)

Three exacerbation events among patients receiving mepolizumab were omitted from the analyses; this affected several parts of the article.In the first paragraph of the Primary Outcome subsection of Results (page 1202), the number of exacerbations given in the first sentence should have been 449, rather than 446.This error also affected Figure 2A.The 95% confidence intervals given in several places in the article were incorrect: In the Abstract (page 1198), the parentheticals in the first sentence of Results should have listed the confidence intervals as 28 to 60, rather than 29 to 61, and 36 to 65, rather than 37 to 65.The same incorrect confidence intervals also appeared in the Primary Outcome subsection of Results (last sentence of the first paragraph, page 1202); in the first row of data under the "Difference from Placebo" heads in Table 2 (page 1204); and in the second sentence of the legend for Figure 2 (page 1205).The rates of clinically significant exacerbations were also affected: In the Primary Outcome subsection of Results (page 1202), the rates given in the penultimate sentence of the first paragraph should have been 0.83 for the subcutaneous-mepoli zumab group, rather than 0.81, and 1.74 for the placebo group, rather than 1.75.These errors in exacerbation rates also occurred in the first row of data in Table 2 (page 1204).The article is correct at NEJM.org.
Association News.
Journal: JAMA (1904)

<h3>AMERICAN MEDICAL ASSOCIATION.</h3><h3>Fifty-fifth Annual Session, at Atlantic City.</h3> To the Members of the American Medical Association, and to Constituent State Associations: The next annual session of the American Medical Association will be held at Atlantic City, New Jersey, on Tuesday, Wednesday, Thursday and Friday, June 7, 8, 9 and 10, 1904. The first general meeting, which constitutes the opening exercises of the scientific functions of the Association, will be held at 10 a. m., Tuesday, June 7. The Registration Department will be open from 8 a. m. to 5:30 p. m., on Monday, Tuesday, Wednesday and Thursday, June 6, 7, 8 and 9, and from 9 to 11 a. m. on Friday, June 10. <h3>NEW MEMBERS.</h3> Those who join the Association at its annual session must present certificates of membership in good standing in their state association or in one of its affiliated branches. <h3>THE HOUSE OF DELEGATES.</h3> The
Pelvic Mass in a 12-Year-Old Girl
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Creeping Bubo
Authors: S. Solly
Journal: BMJ (1849)

soon produce it; and that this power is sometimes lost will be seen in examiilng Case 5 (Worts), in which, although many gallons of water were taken into the stomach, the blood still continued to increase in specific gavity.Assumig that such a condition of intestinal mucous membrane exists in Cholera, it gives us but little hopes of effecting much by remedies administered by the mouth, during the collapse: and experience has shown us, that very little confidence can be placed in them.The saline drinks, recommended by Dr. Stevens, must here fail, as even water is unable to be absorbed.This led to the method of injection of saline fluids into the veins; and certainly it appears that, even in the most intense stage of collapse, patients may, for a time, be restored by their employment.Unfortunately, however, the improvement has, in most cases, proved but temporary; but still enough has been seen, to cause many to think that their use is strongly called for.Should they be ever again employed, I think that more attention should be paid, both to the nature and quantity of the salts contained in the fluid, than has hitherto been done; and a solution should be employed whose composi- tion resembles, as much as possible, the portion of the blood which has been lost.One would be apt to think, that the blood could not bear with impunity a considerable quantity of carbonate of soda in place of the phosphate; yet such a substitution, I believe, has generally been made.May not the use of improper fluids have been in part the cause of the truth of the remark quoted by Dr. Watson, in his Lectures on the Practice of Medicine, that, " However it might be with pigs and herrings, salting a patient in Cholera was not always the same thing as cu7ing him."Might not some agent be injected, which would tend to prevent the exosmotic action of the intestines ?Certain bodies, possessing such a power on membranes, have been found.When reaction takes place, and the watery portion of the blood becomes restored, it would then seem rational to employ drinks containing small quantities of the salts; for it does not seem improbable, that the saline deficiency, which must then occur, unless supplied, may tend to prevent the due action of the kidneys and other excreting organs.At this time also, other remedies, as calomel, etc., should be given, with the intention of restoring the excretions.
Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in metastatic castration-resistant prostate cancer (mCRPC) pts receiving a new agent (NA)-based third line treatment: Preliminary results from a multicenter Italian study.
Authors: Orazio Caffo, Ugo De Giorgi, Daniele Alesini, Lucia Fratino, Cinzia Ortega, Marcello Tucci, Sarah Scagliarini, Vittorina Zagonel, Paolo Andrea Zucali, Franco Morelli, Donata Sartori, Roberto Sabbatini, Alessandro D'Angelo, Maddalena Donini, Sandro Barni, Giuseppe Procopio, Zuzana Sirotova, Teodoro Sava, Vincenza Conteduca, Enzo Galligioni
Journal: Journal of Clinical Oncology (2016)

211 Background: The NLR is a marker of systemic inflammatory response: several studies investigated its prognostic relevance in mCRPC but to date no information is available concerning this issue in pts treated in third line therapy. The present study is aimed to assess the possible relationship between third line clinical outcome and NLR in a large series of mCRPC pts treated with a NA [abiraterone acetate (AA), cabazitaxel (CABA), or enzalutamide (ENZ)] after the failure of docetaxel (DOC) and another NA. Methods: We collected data of pts who received sequentially two NAs after DOC in 38 Italian hospitals. For each pt we recorded the clinical outcome of all treatments received after DOC. Cox regression analysis was used to assess the independent prognostic value of a series of pretreatment covariates, in terms of overall survival (OS), comprising NLR. Results: A consecutive series of 291 mCRPC pts with bone (88%), nodal (53%) or visceral (18%) mets, was collected. All pts received a NA-based third line: 90 received AA, 123 CABA and 78 ENZ. At the time of this analysis, data on NLR were available for 198 pts (68%): AA 68 (75%) – CABA 80 (65%) – ENZ 50 (64%): the median value was 3.1 (IQR 2.2-4.7). In the univariate analyses, the NLR as a discrete variable using the median value of 3.1 as threshold, was significantly associated with both OS and progression free survival (PFS), calculated from the third line start (p &lt; 0.0001 and p = 0.001, respectively). No association was observed with either biochemical or objective response. These results were confirmed at the multivariate analysis. In Kaplan-Meier analysis, the median OS from the start of third-line was higher (18.2 vs 8.1 mos) in pts with NLR ≤ 3.1 compared to those with NLR &gt; 3.1 (log-rank; P &lt; 0.0001). Similarly, the median PFS was 6.3 and 3.5 in pts with NLR ≤ 3.1 and &gt; 3.1, respectively. Conclusions: At the best of our knowledge, this is the first report on the NLR value in mCRPC third line treatment. From our preliminary data, it appears that NLR may be a prognostic and predictive factor in mCRPC pts, treated with NA-based third line.
A New Prognostic Model for Multiple Myeloma Patients in the Era of Novel Agents
Authors: Hyungwoo Cho, Dok Hyun Yoon, Kihyun Kim, Sung-Soo Yoon, Chang-Ki Min, HyeonSeok Eom, Jin Seok Kim, Je-Jung Lee, Jae Hoon Lee, Cheolwon Suh
Journal: Blood (2015)