tbuckley/cabot-search huggingface dataset:
Graduate medical education confronted
Authors: G. T. Perkoff
Journal: JAMA (1988)

RECENT changes in the financing of hospital care have precipitated new activity and interest in graduate medical education by calling attention to preexisting forces already affecting the system. Many things are happening simultaneously. Intensive hospital care of patients with increasingly complex cases admitted to teaching hospitals has limited the scope of both graduate and undergraduate medical education. The high cost and increasing organization of medical care already have led to a steady shift of care from the hospital to the ambulatory setting. Because of these changes, several commentators have recommended expansion of the content of graduate and undergraduate medical education to include more primary care and social and behavioral sciences<sup>1,2</sup>and a shift in its location to ambulatory settings.<sup>3,4</sup>Major changes have been suggested in the specialty mix of graduate medical education, including a new primary care specialty.<sup>5,6</sup>Two separate, large task forces have recommended changes in
Tenth International Convocation on Immunology—Vaccines: New Concepts and Developments
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Tenth International Convocation on Immunology—Vaccines: New Concepts and Developments Get access JNCI: Journal of the National Cancer Institute, Volume 76, Issue 3, March 1986, Page 555, https://doi.org/10.1093/jnci/76.3.555-c Published: 01 March 1986
ALDOSTERONISM, NORMOTENSION, AND RENAL LESIONS—A NEW SYNDROME
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatitis B vaccine to be available in Southeast Asia
Authors: C. Marwick
Journal: JAMA (1983)

On Jan 1, 1984, William W. McLendon, MD, of the University of North Carolina (Chapel Hill) School of Medicine, will become the sixth editor of the American Medical Association'sArchives of Pathology and Laboratory Medicine. He will succeed Kenneth M. Brinkhous, MD, also of that university, who has served as editor for the past ten years. TheArchiveswill also undergo a change in structure in January. As McLendon explains, "We plan to expand into such areas as laboratory improvement, quality assurance, and the use of computer technology in the laboratory setting." This change is the result of an agreement between the College of American Pathologists and the AMA to cosponsor theArchivesso as to expand its subject matter and increase its readership. Says Brinkhous: "This is a good move for the entire pathology community." McLendon, too, believes the joint project may serve as a model for future collaborations
Treatment of chronic depression
Authors: R. L. Spitzer
Journal: JAMA (1996)

<h3>In Reply.</h3> —The authors of these letters express a level of interest in my Clinical Crossroads discussion that is quite gratifying. With regard to Dr Chutkow's comments, I agree that ECT is a safe and effective treatment for depression, especially when it is severe and/or when antidepressants have failed to work. Although the patient under discussion had a history of major depressive episodes, in recent years he suffered from dysthymia, a condition for which ECT is not generally indicated. Chutkow also suggests that the psychiatrist should provide both psychotherapy and pharmacotherapy. While clinical experience suggests that there are some patients for whom this is best, other patients do quite well with nonmedical psychotherapists working collaboratively with the psychiatrist. Indeed, in most controlled studies demonstrating the efficacy of psychotherapy for depression, the therapists have been either psychologists or social workers.<sup>1</sup>What is surely needed are randomized trials of the comparative
Some Current Concepts of Bone Physiology
Authors: Paul Goldhaber
Journal: New England Journal of Medicine (1962)

Citric Acid and Bone MetabolismAlthough the skeleton contains a high concentration of citrate (about 1 per cent in rabbit cortical bone) the origin of this citrate has been disputed. Armstrong and Singer66 support the idea that the major part of the skeletal mineral citrate occurs adventitiously owing to the constant presence in body fluids of citrate originating from nonskeletal tissues. On the other hand, since Dixon and Perkins67 described what appeared to be an enzyme mechanism for accumulating a high, local concentration of citric acid, it was suggested that the bone mineral citrate is derived from bone cells and . . .
Currying favor for the heart
Authors: Jonathan A. Epstein
Journal: Journal of Clinical Investigation (2009)

During the preparation of the manuscript, different fields of the same sample for WGA immunofluorescence staining were mistakenly used to represent 2 distinct treatment groups on 2 occasions, in Figures 2 and7, and some of the raw data for the earlier experiments were lost due to poor record keeping.All authors have agreed to retract the article.
Detecting Alcoholism
Authors: John A. Ewing
Journal: JAMA (1984)

Four clinical interview questions, the CAGE questions, have proved useful in helping to make a diagnosis of alcoholism. The questions focus on Cutting down, Annoyance by criticism, Guilty feeling, and Eye-openers. The acronym "CAGE" helps the physician to recall the questions. How these questions were identified and their use in clinical and research studies are described. (<i>JAMA</i>1984;252:1905-1907)
THE BACTERIOLOGY OF MEASLES
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
University Uses Professional Models in Teaching Neurology
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NATURE OF RHEUMATIC HEART DISEASE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PYEMIA FOLLOWING THROMBOPHLEBITIS OF SUPERIOR VENA CAVA.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Linezolid: The First Oxazolidinone Antimicrobial
Authors: Robert C. Moellering
Journal: Annals of Internal Medicine (2003)

Linezolid is the first of a new class of antimicrobial agents, the oxazolidinones, to be approved for clinical use in the United States and elsewhere. The drug is a totally synthetic compound, which lessens the likelihood of naturally occurring resistance mechanisms. It has excellent activity against virtually all important gram-positive pathogens, including methicillin-resistant staphylococci, penicillin-resistant pneumococci, macrolide-resistant streptococci, and vancomycin-resistant enterococci. Development of resistance to the compound has been infrequent thus far. Linezolid is 100% bioavailable, so it can be given in equal doses orally or parenterally. Its elimination half-life allows dosing twice per day, and alteration of drug dosage is not required in patients with impaired renal or hepatic function. Linezolid has approved indications for skin and soft tissue infections; lower respiratory tract infections; and vancomycin-resistant Enterococcus faecium infections, including cases with concurrent bacteremia. The drug has an acceptable profile of adverse events, but reversible myelosuppression has occurred in patients receiving high doses for more than 2 weeks.
Verhandlungen der Berliner medicinischen Gesellschaft aus dem Gesellschaftsjahre, 1897, Band xxviii.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Catheter Measures Renal Artery Pulse
Journal: JAMA (1966)

Astandardter of the type designed for recording sounds within the heart has been successfully used by investigators at the Cleveland Clinic to obtain indirect measurement of the renal artery pulse. In a first report of an extensive clinical trial of this technique, introduced three years ago, William S. Kiser, MD, told the Third International Congress of Nephrology that pulse variations diagnostic of renal vascular lesions can be obtained by inserting the catheter into the ureter. <h3>Phonorenograms</h3> In patients with unilateral renal artery stenosis, the "phonorenograms" obtained by this method consistently demonstrated a distinct reduction in the amplitude of the transmitted pulse as compared to the pulse registered on the normal side. As with most renal function tests, however, the technique is of little diagnostic value when both sides are equally involved. In a comparative study of 25 hypertensive patients with renal artery disease, results obtained with the phonocatheter correlated more
Effects of zinc administration on liver fibrosis and portal hypertension in bile duct ligated rats JL Poo, A Martínez, K Suzuki, A Estanes, G González, V Ruíz, F Rodríguez, JL Silencio, M Uribe. Liver Clinic. Instituto Nacional de la Nutrición, Salvador Zubirán. México City, México
Journal: Hepatology (1994)
Persistence of digoxin effect in atrial fibrillation
Authors: J. C. Zener
Journal: JAMA (1973)

Radioimmunoassay of digoxin and measurements of ventricular rate at rest and exercise were performed four times daily during maintenance therapy and following discontinuation of the drug in five patients with atrial fibrillation. No consistent diurnal variation in ventricular rate during maintenance therapy was observed despite fluctuations in plasma digoxin levels. Following withdrawal of the drug, the chronotropic effect persisted longer than would be expected from the plasma elimination rate. Our findings imply that a divided daily dose for the control of atrial fibrillation is not required; a single dose suffices.
Interferon/ribavirin combination therapy with and without dailydosingin retreatment of chronic hepatitis C
Authors: T. Bernatik, H. Klinker, M. Scheurlen, H. Meyer, W. Norgauer, W. Rambach, U. Sapper, E.G. Hahn, D. Schuppan, H.T. Schneider
Journal: Journal of Hepatology (2000)
Editorial
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improved imaging offers look at whole body
Authors: P. Gunby
Journal: JAMA (1983)

Medical imaging's centennial is about a decade away, but there is much to celebrate already. More information is being extracted from more body areas for more purposes than ever before. For the most part, the imaging equipment and techniques used to study the CNS (see last week's<i>JAMA</i>MEDICAL NEWS) are finding increasing uses elsewhere in the body. Among these, a relative newcomer to clinical diagnosis, the experimental technique of nuclear magnetic resonance (NMR), continues to hold much of the spotlight. Said Ferdinando S. Buonanno, MD, of the Neurology Service, Massachusetts General Hospital (MGH), Boston, at the American Association of Neurological Surgeons meeting in Honolulu: "NMR shows soft tissue very well, so it probably will have greater application outside the head. You can look at the abdomen, see kidney structure, blood vessels, tendons around muscles, and there's nothing short of cutting open and looking inside that comes close." Juan M.
T cell regulation of b cell activation. Cloned Lyt-1+2-T suppressor cells inhibit the major histocompatibility complex-restricted interaction of T helper cells with B cells and/or accessory cells.
Authors: Y Asano, R J Hodes
Journal: The Journal of Experimental Medicine (1983)

The present studies have identified cloned Lyt-1+2- T suppressor (Ts) cells that are both antigen specific and major histocompatibility complex (MHC) restricted in their activation requirements and that function to regulate the MHC-restricted activation of B cells by T helper (Th) cells. ParentA-restricted Ts clones suppressed, in antigen-specific fashion, the responses generated by (A X B)F1 Th cells cooperating with parentA (B plus accessory) cells, but did not suppress responses by the same (A X B)F1 Th cell population cooperating with parentB (B plus accessory) cells. Moreover, responses of (A X B)F1 leads to parentA Th cells and (A X B)F1 (B plus accessory) cells were suppressed by parentA-restricted Ts clones but not by parentB-restricted Ts clones. Thus, these findings suggest that the cloned Ts cells that have been characterized here function by specifically inhibiting the MHC-restricted interaction between Th cells and B and/or accessory cells. It was further demonstrated in experiments using cloned Th and Ts populations that these Lyt-1+2-Ts cells act not simply as inducers of suppressor but rather function in a restricted fashion as effector cells in the suppressor pathway.
Bibliomania
Authors: Charles G. Roland
Journal: JAMA (1970)

Although bibliomania has existed as long as there have been books, the condition had no generally accepted name until about a century and a half ago. Then a physician in Manchester, England, published a poem entitled "Bibliomania" (reprint, Philadelphia, 1866), dedicating it to a bibliomaniac friend. John Ferriar was the physician, Richard Heber the friend. John Ferriar (1761-1815) studied medicine at Edinburgh, graduating in 1781. Although he conducted a busy medical practice for the remainder of his life, he also achieved a contemporary reputation based in large part upon his studies of Massinger, the dramatist, and Lawrence Sterne. Ferriar also published poetry, a play, lengthy autobiographical reflections, and essays on a variety of medical, literary, and philosophical topics. Richard Heber (1773-1833), an Oxonian of independent wealth, early in life developed an unquenchable interest in books. So great was his aquisitive spirit that when he died, he left a total of
对中度至重度斑块状银屑病患者采用延胡索酸酯并配合为期六周的窄带紫外线B疗法比单独采用延胡索酸酯治疗的效果更加有效:一项随机前瞻性临床研究
Authors: S. Tzaneva, A. Geroldinger, H. Trattner, A. Tanew
Journal: British Journal of Dermatology (2018)

银屑病是一种慢性、复发性、炎性皮肤症状,对患者的生活质量会产生严重的影响。这种病影响着西方国家约2~3%的人口,由免疫系统的调节异常导致。银屑病的起因和发展相当复杂,涉及基因和环境因素。斑块状银屑病是最常见的一种银屑病,表现为凸起的红色皮肤损伤并带有银白色片状表面。银屑病无法治愈,但目前的治疗可以抑制症状的发展。延胡索酸酯(FAE)在可以使用该药的欧洲国家中属于一线治疗方案。FAE有效且较为安全,但需要一段时间才能起效。结合短期的窄带紫外线(NB~UVB)光线疗法可克服此缺点,并有助于加快治疗早期阶段的反应。我们的随机对照前瞻性试验旨在调查最初向FAE中增加NB~UVB是否能够改善斑块状银屑病患者的临床反应和生活质量。执行此研究的研究人员来自奥地利维也纳医科大学皮肤系。患者被随机(碰巧)分配至两个治疗组中:一组仅接受FAE治疗,而另一组则接受FAE和为期六周的窄带UVB组合治疗。我们发现,向FAE中增加短期NB~UVB治疗可以加快且改善银屑病的清除效果及患者的生活质量。
QuickStats: Repeat* Birth Rates for Teens,† by Urbanization Level of County§ — National Vital Statistics System, 2007–2016
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Repeat births are second and higher-order births.Birth order refers to the number of children born alive to the mother.Births recorded with no birth order stated are proportionately distributed across birth order categories.† The number of repeat births to females aged 15-19 years per 1,000 females aged 15-19 years.§ Urbanization level is based on maternal county of residence.Counties were classified according to their metropolitan status using the National Center for Health Statistics Urban-Rural Classification Scheme.https:// www.cdc.gov/nchs/data_access/urban_rural.htm.
NMR used to study drugs' toxic effects
Authors: Heather Carswell
Journal: JAMA (1982)

Nuclear magnetic resonance (NMR) spectroscopy is fast gaining recognition as a potentially powerful tool for the study of metabolic events in tissue, including those produced by drugs. Researchers at the University of Texas Southwestern Medical School at Dallas have been using NMR to study the nature of the cardiotoxic effects of the anticancer agent doxorubicin hydrochloride (Adriamycin) on rabbit hearts by analyzing the resonance signals emitted by phosphorus 31. Preliminary findings, says biophysicist Ray L. Nunnally, PhD, suggest that in vivo spectra produced by NMR not only identify the early cardiac changes that lead to irreversible damage but also may help pinpoint how doxorubicin exerts its injurious effects at the molecular level. A long-established drug, doxorubicin is used to treat a wide variety of cancers. Careful adherence to guidelines for use of the drug has limited the incidence of cardiotoxicity to less than a few percent of patients. Irreversible damage,