tbuckley/cabot-search huggingface dataset:
Whooping-cough due to adenovirus.
Journal: BMJ (1970)

in each clinic to see that they are standardized.In too many clinics women are weighed just as they come in off the street.This is not good enough to be used in deciding whether a given woman's weight is static or falling.But gain or loss of weight, girth, and clinical suspicion based on palpation are not enough to be sure of the diagnosis of small-for-dates fetus.The suspicion is best checked by some test of placental function.The most widely used are those based on the quantitative excretion in the urine of oestriol5 or pregnanediol6 or both.It is assumed that the endocrine function runs parallel with the nutritional and respiratory functions of the placenta.This seems to be largely true, and the tests are of undoubted help in prognosis and in guiding the clinician on the best time for delivery of the fetus.An especially interesting test, not yet widely used, is that of measuring the uptake of radioactive selenomethionine.7This isotope-labelled amino-acid is used in a direct attempt to measure the nutritional state of the fetus.In 50 cases the test identified the four babies with retardation of intrauterine growth.Another direct measurement of the fetus is that of the biparietal diameter by means of ultrasound.8The mean and standard deviations of the biparietal diameter with gestational age are now known, and provided a series of readings can be obtained in the individual case they can be used either to estimate maturity or, if the gestational age is known with fair accuracy, to detect retardation of growth.And this pinpoints one of the major clinical difficulties.These
The President's Visit
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advisory Committee report recommends that US make amends for human radiation experiments
Authors: A. A. Skolnick
Journal: JAMA (1995)

THE US GOVERNMENT should apologize to hundreds of citizens who were used in ionizing radiation experiments conducted from the 1940s into the 1970s—often without their consent or even their knowledge. The government should also compensate those who were harmed by the experiments, or their survivors. These are the recommendations the Advisory Committee on Human Radiation Experiments has made in its final report, which is due to be released. The committee, which was established by an executive order of President Clinton in January 1994, was charged with investigating the ethical and scientific aspects of human radiation experiments carried out or sponsored by the US government. <h3>Find the Answers</h3> According to Stephen Klaidman, counselor to the committee and director of communications, the committee was charged with finding answers to several questions, including what ethical criteria should be used to evaluate human radiation experiments, what was the federal government's role in past human
Abstract 3622: End of Trial Period for Randomized Controlled Cardiology Trials: Is patient safety monitored and protected?
Authors: Mohammad I Zia, Ronald Heslegrave, Gary E Newton
Journal: Circulation (2007)

Background: The post trial period is the period after the end of study drug administration. The Declaration of Helsinki (DOH) states that “at the conclusion of the study, every patient entered into the study should be assured of access to the best proven prophylactic, diagnostic and therapeutic methods identified by the study.” It further adds that “post trial access arrangements or other care must be described in the study protocol so the ethical review committee may consider such arrangements during its review.” Therefore our objectives were: to determine whether research trial protocols systematically consider post trial period issues including planned follow-up and patient surveillance in the post trial period; and to assess if consent forms addressed end of trial issues. Methods: We searched the research ethics board (REB) databases at 2 academic institutions in Toronto from 1995 to 2006 to identify approved randomized clinical trials of chronic medical therapies for cardiac conditions. Results: Fourty-two studies were identified including 18 heart failure and 15 coronary artery disease trials. Thirty-eight of these trials were industry funded. Almost all trials (n=37) ended study drug abruptly at the last clinic visit, while only 4 studies offered a clinical visit post trial termination, and an additional 3 reported a telephone contact after trial completion. Only 5 trials submitted consent forms to the REB with a discussion of the post trial period. After REB review, no additional consent forms addressed the post trial period. When comparing the time period before and after the updated version of the DOH in 2000, there was a trend towards a decline in addressing post trial care (p=0.08). Conclusion: The majority of cardiac trials end study drug abruptly with unknown and potentially negative consequences, and most patients have no systematic post trial follow up from trial investigators. Study patients are also not made aware of the post trial period, as the majority of study consent forms do not discuss post trial care. Therefore, an important aspect of clinical trial design, the post trial period, could be improved by systematic follow-up described in the protocol, and full discussion of this aspect of trial participation in the consent form.
Experience with single-lung transplantation for pulmonary fibrosis. The Toronto Lung Transplant Group
Journal: JAMA (1988)

Repeated success has now been obtained with single-lung transplantation for end-stage pulmonary fibrosis. Potential candidates for this procedure are individuals who are less than 60 years of age and who have progressive pulmonary deterioration with limited life expectancy. Since November 1983, eleven such transplantations have been performed; nine patients achieved discharge from the hospital and eight patients have remained alive up to 44 months after surgery. All of these recipients have good oxygenation on room air and good exercise tolerance and are capable of performing routine activities, including a return to previous employment. From our experience, it appears likely that single-lung transplantation can achieve the same success rates as other major organ transplantations.
Goodpasture's dilemma
Authors: J. M. Merrill
Journal: JAMA (1985)

<h3>In Reply.—</h3> Dr Goldberg's comments are appreciated, but they fail to describe the entire panorama of events following intimal damage by a variety of means such as surgical anastomosis, balloon angioplasty, Fogarty catheter endothelial stripping, surgical endarterectomy, or laser recanalization. More than platelet aggregation and release of growth factor occur. Local tissue prostacyclin production leading to lysis of thrombi is another factor that must be considered. Preliminary work by our group with Dr B. Weksler, Cornell University Medical Center, confirms the report by Abela et al<sup>1</sup>of increased prostacyclin production after laser irradiation of arterial tissue. This would tend to prevent new thrombus formation. Blood flow velocity over the lasered segment is another factor. Chesebro and Frye<sup>2</sup>showed increased incidence of occlusion of bypass vein grafts when flow was less than 40 mL/min. Prioleau et al<sup>3</sup>reported blood flow that was reduced to 14 mL/min in vein
Survivors of Out-of-Hospital Cardiac Arrest With Apparently Normal Heart
Journal: Circulation (1997)

Background A wide variety of structural abnormalities are associated with the vast majority of cardiac arrests. However, there is no evidence of structural heart disease in ≈5% of victims of sudden death, indicating that cardiac arrest in the absence of organic heart disease is more common than previously recognized. The risk of recurrence and the acute and long-term response to therapy are important but unanswered questions. Data from the small series reported so far are of limited value because of the lack of uniform criteria to define and diagnose idiopathic ventricular fibrillation (IVF). Methods and Results This report originates from a Consensus Conference convened by the Steering Committees of the European (UCARE) and North American (IVF-US) Registries on IVF under the auspices of the Working Group on Arrhythmias of the European Society of Cardiology. Its objective is to provide a unified definition of IVF and to outline the investigations necessary to make this diagnosis. Minimal diagnostic tests for the exclusion of an underlying structural heart disease include noninvasive (blood biochemistry, physical examination and clinical history, ECG, exercise stress test, 24-hour Holter recording, and echocardiogram) and invasive (coronary angiography, right and left ventricular cineangiography, and electrophysiological study) examinations. Programmed electrical stimulation, ventricular biopsy, and ergonovine test during coronary angiography are recommended but not mandatory. Conclusions It is recognized that despite careful evaluation, conditions such as focal cardiomyopathy, myocarditis, or fibrosis and transient electrolyte abnormalities may remain silent. Therefore, patients should undergo careful follow-up, with noninvasive tests repeated every year. The existence of a unified terminology will allow meaningful comparison of data collected by different investigators and will thus contribute to a better understanding of IVF.
The appetite of pregnant women
Authors: R. L. Landau
Journal: JAMA (1983)

Why do pregnant women eat more? On the surface, this is another of those biomedical questions that need not be asked. Simplistically, the answer is so obvious: baby, placenta, uterus, and breasts are growing. More protein, calories, and other nutrients are required for the growth. The nutrients for the growing transplant are transported actively and passively from the pregnant woman's circulating plasma. The real question then, is how does this growing tissue, most of it in a sense "outside" her body, result in an increased appetite? The normal pregnant woman does indeed have a positive energy balance. She eats more calories than she expends. When food is plentiful, many pregnant women not only consume enough during the pregnancy to compensate for the demands of the growing products of conception, but a surfeit, which results in a net storage of fat. Obstetricians sometimes need to caution and instruct pregnant women to
The Public Service.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I-II Trial of Oral Cyclophosphamide, Prednisone and Lenalidomide (Revlimid®) (CPR) for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
Authors: Donna E. Reece, Esther Masih-Khan, Arooj Khan, Saima Dean, Sharon Fung, Peter Anglin, Christine Chen, Vishal Kukreti, Joseph R. Mikhael, Suzanne Trudel
Journal: Blood (2010)
DURATION OF PREGNANCY
Authors: Lester M. Levy
Journal: JAMA (1952)

<h3>To the Editor:—</h3> The work that was described by Dr. H. L. Stewart Jr. in his article "Duration of Pregnancy and Postmaturity" (<i>J. A. M. A.</i><b>148</b>:1079 [March 29] 1952) has, without doubt, cast much light on the true duration of pregnancy. In a group of 135 women, he was able to determine the elapsed time between ovulation or conception (as detected by the basal body temperature method) and the onset of spontaneous labor. He found that this interval ranged between 250 and 285 days, with an average of "266 to 270 days." Furthermore, he was able to demonstrate that, in his series, what seemed to be prolongation of pregnancy was only apparent, being due to the fact that duration was counted from the first day of the last menstrual period. This led to errors in the estimate of pregnancy duration when ovulation was unusually delayed after the last
A 72-Year-Old Man With Localized Prostate Cancer—14 Years Later
Authors: Tom Delbanco
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review
Journal: British Journal of Dermatology (1930)

Abstract Book Reviewed in this article: Die Lepra der oberen Luftwege umd des Ohres, in Palestina und Cypern. By Dr. M.SALZBERGER Syphilitische und Syphilogene Magenerkrankungen (Gastrolnes). By Prof. ROMAN LuRiA (Kasan Die Technih und Anwendung der Subocdpital- oder Zislernenpunktion. By Dr.ALOIS MEMMESHEIMER
Diagnosis of Esophagogastric Tumors
Authors: M Moretó
Journal: Endoscopy (2001)

The incidence of esophageal tumors, and of adenocarcinoma in particular, has risen markedly in recent years in the developed countries. The use of a variety of histopathological and biological markers is now offering promising prospects for the future. Vertical tumor invasion, intratumoral microvessel density, antimucin monoclonal antibodies, flow cytometry, telomerase activity, and overexpression of cyclin D1 have been correlated with the staging and prognosis of esophageal carcinomas. By combining these markers with Lugol staining, a practical new method of staging esophageal tumors may become available in the coming years. As is well known, Barrett's mucosa is a preneoplastic condition. Discussions in the literature concerning short forms of Barrett's esophagus and their relationship to inflammation of the gastric cardia appear to describe two different scenarios--a gastroesophageal reflux condition for short forms of Barrett's esophagus, and an inflammatory phenomenon (perhaps unrelated to Helicobacter pylori infection) for inflammation of the gastric cardia. Cost-benefit studies of follow-up procedures in Barrett's esophagus have yet to be conducted, and considerable efforts--mainly using biological markers--are being made to identify those patients who are at greatest risk. Although the frequency of gastric tumors has declined in recent years, many as yet unclear aspects of these tumors have been studied. Technological progress has not led to substantial changes in the diagnostic procedures used, although autofluorescence methods and three-dimensional reconstruction have been analyzed. Laparoscopy, preferably combined with the use of ultrasound probes, may be a valuable tool for staging. The suggestion that endoscopy should be avoided in young patients (the "treat but do not scope" approach) has been seriously questioned, as it may lead to early cancer being overlooked. There is thought to be an intermediate stage of gastric cancer (between the early and advanced stages) in which the muscularis propria, but not the serosa, is invaded. Endoscopic ultrasonography is becoming increasingly established as a basic tool for the staging of gastric cancer. Gastric MALT lymphoma can be cured by H. pylori eradication therapy in many cases, but there is still uncertainty regarding the limitations of this approach.
THE SECTION ON DISEASES OF CHILDREN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POSTGRADUATE WORK IN PARIS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Subungual squamous cell carcinoma
Authors: F. F. Attiyeh
Journal: JAMA (1979)

Twelve patients with subungual squamous cell carcinoma were treated at Memorial Sloan-Kettering Cancer Center during a 27-year period. To our knowledge, only 58 cases are reported in the literature. Trauma and chronic infection were predisposing factors in some of the cases, and radiation therapy was a substantive predisposing factor in our series. Disarticulation of the distal phalanx proved effective in most patients. (<i>JAMA</i>241:262-263, 1979)
ANOTHER STEP TO PROTECT CHILDHOOD.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE GERMS OF TYPHOID FEVER.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal