tbuckley/cabot-search huggingface dataset:
Abstract 4698: Myocardial Radial Strain Rate Indicates Prognostic Significance in Asymptomatic Patients with Chronic Severe Aortic Regurgitation
Authors: Tetsuari Onishi, Hiroya Kawai, Maky Furuki, Yuko Fukuda, Mariko Okada, Kazuko Norisada, Kazuhiro Tatsumi, Yutaka Okita, Ken-ichi Hirata
Journal: Circulation (2008)

(Purpose) The purpose of this study was to investigate the prognostic value of myocardial systolic strain rate (Ssr) in the initial evaluation in asymptomatic patients with chronic severe aortic regurgitation (AR). (Methods) We studied 50 patients with severe AR and moderately dilated left ventricle (LV) who did not present with the operative indication in the initial evaluation. During an average of 24 months follow-up period, 15 patients underwent surgical corrections (group S) and remaining 35 did not require them (group M). In the initial echocardiographic examination, we obtained end-diastolic and end-systolic LV dimensions, radius to thickness ratio (R/T) and end-systolic wall stress (WS) from M-mode echocardiograms, and end-diastolic and end-systolic LV volume indices (EDVI and ESVI), LV ejection fraction (EF) using the modified Simpson’s method, and radial Ssr on the LV posterior wall using tissue Doppler imaging. We used a student t-test for 2 group comparison and the receiver-operating characteristic curve (ROC) to search for a predictor from parameters. (Results) There was no significant difference in EF, R/T, and WS between two groups in the initial evaluation. However, EDVI and ESVI in group S were significantly larger and Ssr in group S was significantly smaller than those in group M. In ROC analysis, we identified the area under the curve of Ssr was greater than that of the other variables. Kaplan-Meier analysis according to the cutoff value (Ssr 2.4/s) determined by analysis of ROC demonstrated a significantly lower operation-free rate in patients with Ssr &lt; 2.4/s than in those with Ssr ≥ 2.4/s (p &lt; 0.001). (Conclusions) Myocardial systolic strain rate is a valuable predictor for the progression of disease, and may be helpful for the risk assessment in the serial evaluation of asymptomatic patients with chronic AR.
Analysis of anaphase in cell culture: an adequate test system for the distinction between compounds which selectively alter the chromosome structure or the mitotic apparatus
Authors: R R Coutiño
Journal: Environmental Health Perspectives (1979)

A system of anaphase analysis is presented as an adequate test to detect aberrations in chromosome structure and alterations in the mitotic apparatus.Particular emphasis is placed on those data which suggest that proteins may be the preferred targets of chemical compounds that induce aneuploidy.
Blood volume
Authors: S. N. Albert
Journal: JAMA (1966)

The dynamics of circulation are regulated by numerous mechanisms. One of the many factors that can alter hemeostasis is blood volume, the amount of blood that fills and distends the cardiovascular system. Measuring blood volume serves to establish a possible cause and effect relationship between disorders of circulation and blood volume (persistent hypotension, poor tissue perfusion, hypertension and circulatory overload).<sup>1,2</sup> Measuring blood volume has diagnostic applications—to differentiate between relative and true blood disorders (relative anemia due to expansion of plasma volume, relative polycythemia resulting from dehydration and hemoconcentration). A 29-year-old woman was admitted for removal of a benign thyroid nodule. Her hematocrit level was 32% and hemoglobin value 9.8 gm/100 cc. She related a history of anemia being treated for the past two years. Blood volume measurement showed a normal red blood cell (RBC) volume for her weight and a marked increase in plasma volume. The information obtained from
Erkennung und Behandlung der organischen Lösungsmittelvergiftungen
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA 100 Years Ago
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
La Epidemia of Grippe de 1918-19.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5292: Cell-autonomous suppression of colon carcinogenesis by type-2 cGMP-dependent protein kinase
Authors: Bianca N. Islam, Yali Hou, Sarah K. Sharman, Darren D. Browning
Journal: Cancer Research (2019)

Abstract A growing body of evidence demonstrates that cGMP signaling has anti-tumor effects in the colon, and could harbor novel targets for colon cancer prevention. The tumor suppressive components that function downstream of cGMP remain largely understudied. In the present work we have characterized the expression of cGMP-dependent protein kinases (PKG1, PKG2) in normal and cancerous tissue from humans. PKG1 was highly expressed in both normal and tumor tissue, where it localized to supportive cells in the lamina propria and stroma (respectively). In contrast, PKG2 expression was notably decreased in tumors compared to matched normal tissue, where it was identified in the epithelium by IHC. Neither PKG isoform was detected at the RNA or protein level in colon cancer cell lines. To interrogate a potential tumor-suppressor role of PKG2 in the colon epithelium we bred PKG2 knockout (KO) mice into a C57BL/6J background. These animals exhibited increased intestinal turnover as reflected by crypt hyperplasia (Ki67) and elevated luminal apoptosis (cleaved caspase 3). When subjected to AOM/DSS treatment, the PKG2 KO mice developed almost twice the number of polyps per mouse as wild type siblings (1.75-fold, p=0.0037). Mouse colon organoids were used to confirm that PKG2 was the only isoform expressed in the epithelium, where it was observed in both proliferating and differentiating epithelial compartments. Colon organoids derived from PKG2 KO mice exhibited more rapid proliferation, and a reduced ability to differentiate compared to wild type controls. Taken together our results show that PKG2 is the central target of cGMP in the colon epithelium, where it suppresses carcinogenesis by controlling proliferation in a cell autonomous manner. Citation Format: Bianca N. Islam, Yali Hou, Sarah K. Sharman, Darren D. Browning. Cell-autonomous suppression of colon carcinogenesis by type-2 cGMP-dependent protein kinase [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5292.
Dead wrong
Authors: T. Dalrymple
Journal: BMJ (2008)

OBJECTIVE: To explore some of the problems encountered in the postal administration of the Short-Form 36 (SF-36). Questions that seem to present particular difficulties for the group are identified. In addition some of the written comments from the questionnaires and people9s responses to questions on how difficult they found the SF-36 are discussed. DESIGN: The study group were asked to complete a health questionnaire containing the SF-36 on three separate occasions (at zero, three, and six months). The first and final questionnaires were interviewer administered during a face to face interview. A shorter questionnaire containing only the SF-36 and another health status measure was sent by post to each patient in the interim. PARTICIPANTS: People aged 65 years or above who were new referrals to community based occupational therapy or physiotherapy services in three areas in north west England. MAIN RESULTS: Response and completion rates for the postal questionnaire were lower than expected, even though all the patients had already had a face to face interview and had therefore completed the SF-36 once. Only 34 of 56 respondents (60.7%) completed all the items on the SF-36. CONCLUSIONS: All those planning to use the SF-36 (and similar measures) with older populations should be sensitive to the problems of postal administration. Non-return of questionnaires, high levels of missing data on those that are received, and ambiguities in response may mean that other measures, or perhaps alternative research methods, are more appropriate.
Satellite Videoconference on Pertussis and Poliovirus Vaccines
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infektionskrankheiten
Authors: Norman B. Roberg
Journal: JAMA (1967)

This first of a three-volume series covers viral diseases. The distinguished authors are predominantly German and Swiss; others are American, Austrian, Czechoslovakian, Egyptian, Finnish and Greek; and the references are often one fourth to two thirds American, British, and Scandinavian. Although written in German, the sources and opinions are inter- and supranational. The editors have achieved their purpose of providing a modern, thorough clinical presentation which, complementing texts on microbiology, constitutes a basis for understanding, recognizing, and preventing viral diseases—a need seldom met by the brevity and condensation in standard textbooks of medicine. The clinical presentations, with the exception of infectious hepatitis, are consistently critical, thorough and vivid. The clinician not specialized in infectious disease is oriented quickly by the excellent 12-page introduction, which explains the classification of viruses and the clinical manifestations, and also by the sections of each monograph describing history, pathogens, pathogenesis, pathology and epidemiology. These provide
Medical Education and Research in Britain
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RESPONSE OF THE COLON TO CATHARTICS
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Classification of polymyositis
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Reviews
Journal: British Journal of Dermatology (1978)

British Journal of DermatologyVolume 98, Issue 5 p. 595-596 Book Reviews First published: May 1978 https://doi.org/10.1111/j.1365-2133.1978.tb01951.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Book reviews in this article: Lehrbuch der Haut Krankheiten und Venerischen Infectionen für Studierende und Arzte. By Theodor Nasemann and Wolfard Sauerbrey Cytostatica in der Dermatologie. By A. Luger Lecture Notes on Dermatology, 4th edn. By Bethel Solomons Volume98, Issue5May 1978Pages 595-596 RelatedInformation
Correction: Prevention of melanoma in Torbay
Authors: G Carter, J Pryor
Journal: BMJ (1993)

Two drugs are better than one EDITOR,-We disagree with some of D E Price's views on managing erectile dysfunction in diabetes.'The erectile dysfunction is not always organic in origin since psychogenic factors based on anxiety are as common in diabetic patients as in the general population.A total lack of erections under all circumstances, including during sleep and on waking, may indeed be due to neurogenic impotence, but patients with this are a minority.Patients more commonly complain of a partial erection during sexual activity, which suggests a vasculogenic rather than a neurogenic cause.Intracavernous injection of a vasoactive agent is a simple means of distinguishing vasculogenic from psychogenic and neurogenic impotence.More sophisticated investigations are rarely neces- sary except to investigate the possibility of occult neurological problems or of arterial disease worth treating surgically-that is, in young non-smoking men under 40 who do not have diabetes or hypertension.The use of intracavernous agents for erectile dysfunction has indeed revolutionised the management of this problem, but, at least in theory, papaverine should not now be used alone because of the occurrence of penile fibrosis and priapism.The incidence of these complications is diminished by the addition of phentolamine, but prostaglandin E1 is safer, although a suitable formulation for general use is not yet available.
The Age of the Hand
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary
Authors: G. G. Liddle
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal