tbuckley/cabot-search huggingface dataset:
Malaria Prophylaxis
Authors: THOMAS L. KURT
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 February 1977Malaria ProphylaxisTHOMAS L. KURT, M.D., M.P.H.THOMAS L. KURT, M.D., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-240_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the November issue a significant omission occurred in "Immunization for the Internist" by Rimland, McGowan, and Shulman (Ann Intern Med 85:622-629, 1976). In describing their recommendations for travelers to foreign countries, malaria prophylaxis was not mentioned.Four hundred forty-seven cases of malaria were reported in the United States and Puerto Rico in 1975, representing a 38.4% increase over 1974 (1). Among these were 430 civilian cases, of which 45.8% were U.S. citizens. A special section entitled "Malaria Prophylaxis" in the Center for Disease Control's (CDC) "Health Information for International Travel" describes malaria prophylaxis in detail, which...References1. Malaria—United States, 1975. Morbid Mortal Weekly Rep 25:325-326, 1976 Google Scholar2. Health Information for International Travel, 1976. Atlanta, CDC Publication No. 76-8280, 1976, pp. 23-35 Google Scholar1. BARRETT-CONNOR E: Advice to travelers. West J Med 123:22-30, July 1975 MedlineGoogle Scholar2. Health Information for International Travel, 1976. Atlanta, CDC Publication No. 76-8280, 1976, pp. 1-80 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS L. KURT, M.D., M.P.H.Affiliations: Department of Preventive Medicine University of Colorado Medical Center Denver, CO 80220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1977Volume 86, Issue 2Page: 240-241KeywordsGlobal healthHealth information technologyMalariaProphylaxis ePublished: 1 December 2008 Issue Published: 1 February 1977 PDF downloadLoading ...
Enterococcal endocarditis
Authors: S. Wessler
Journal: JAMA (1968)

Dr. Richard Miller*: A 65-year-old white man entered Jewish Hospital on May 19, 1967, with chief complaints of fever, chills, and malaise. He had had a suprapubic prostatectomy on Feb 3, and had required 3 units of blood postoperatively. He was discharged one month later with an hematocrit reading of 30%. Fever and chills occurred in late February, again in March, and one week prior to admission. At the time of the third episode the patient had an oral temperature of 103 F (39.4 C). He was treated with chloramphenicol, but continued to have fever and chills. There was no past history of heart disease, heart murmur, or rheumatic fever. There appeared to be a well-documented allergy to penicillin. Physical examination on admission showed a regular pulse rate of 88 beats per minute, an oral temperature of 100 F (37.8 C), and a blood pressure of 116/68 mm Hg. A
Iron fortication of baby foods and sudden infant death
Authors: S. Ayres
Journal: JAMA (1973)

<h3>To The Editor.—</h3> Patient noncompliance represents one of the greatest therapeutic challenges facing the medical profession today. The recent article by Weintraub et al (224-481, 1973) represents an important step in documenting the clinical consequences of such patient behavior. We would like to stress the point, mentioned by the authors, that their noncompliance rate of 34% is surely an underestimate of the true magnitude of the problem. There are two reasons for this: (1) the method of patient self-reporting has been shown to yield noncompliance rates that are approximately one half of those determined in the same patients by pill counts or other methods<sup>1-3</sup>; and (2) there is some evidence that noncompliance rates measured at the time of scheduled clinic visits (even without prior telephone contact) tend to be lower than those obtained by unannounced home visits.<sup>4</sup>Hence, the true rate of noncompliance in the present study may
Patient-derived ECM-scaffolds of colorectal cancer and liver metastases as organotypic 3D model of liver metastatic colonization
Authors: Edoardo D’Angelo, Dipa Natarajan, Francesca Sensi, Lola Ajayi, Matteo Fassan, Enzo Mammano, Pierluigi Pilati, Piero Pavan, Silvia Bresolin, Melissa Preziosi, Rosa Miquel, Yoh Zen, Shilpa Chokshi, Krishna Menon, Nigel Heaton, Gaya Spolverato, Martina Piccoli, Roger Williams, Marco Agostini, Luca Urbani
Journal: Journal of Hepatology (2020)
Front &amp; Back Matter
Authors: Matthias Berking, David Ebert, Pim Cuijpers, Stefan G. Hofmann, Kerstin Jung, Regina Steil, Martin Bohus, Anne S. Dyer, Kathlen Priebe, Antje Krüger, Nikolaus Kleindienst, Christian Schmahl, Inga Niedtfeld, Regina Steil, Austyn Snowden, Hasse Karlsson, Jussi Hirvonen, Jouko Salminen, Jarmo Hietala, Wolfram Schüffel, Battuvshin Lkhagvasuren, Tomoaki Masuno, Yoshio Kanemitsu, Nobuyuki Sudo, Chiharu Kubo, Takakazu Oka, Giovanni A. Fava, Richard Balon, R. Delle Chiaie, G. Trabucchi, Elfriede Greimel, Martha Dorfer, David J. Houlihan, Elena Tomba, N. Girardi, I. Marini, R. Pannese, L. Vergnani, M. Caredda, M.P. Zerella, A. Minichino, A. Corrado, F.R. Patacchioli, S. Simeoni, M. Biondi, Michaela Lambauer, Vesna Bjelic-Radisic, Susanne Gramm, Manfred Lahousen, Uwe Lang, Marijke L. Swart, Annette M. van Schagen, Jaap Lancee, Jan van den Bout, Per Bech, David Ebert, Torsten Tarnowski, Mario Gollwitzer, Bernhard Sieland, Matthias Berking, Satz Mengensatzproduktion, Druck Reinhardt Druck Basel, Druck Reinhardt Druck Basel
Journal: Psychotherapy and Psychosomatics (2013)
Board of Trustees Report
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books Received
Authors: Marianne J. Heins, Hans Knoop, Judith B. Prins, Maja Stulemeijer, Jos W.M. van der Meer, Gijs Bleijenberg, Anita Jansen, Sophie Stegerman, Anne Roefs, Chantal Nederkoorn, Remco Havermans, Kirsi Honkalampi, Soili M. Lehto, Jukka Hintikka, Heli Koivumaa-Honkanen, Leo Niskanen, Heimo Viinamäki, Thomas Unterbrink, Linda Zimmermann, Ruth Pfeifer, Uwe Rose, Andreas Joos, Armin Hartmann, Michael Wirsching, Joachim Bauer, Carolina Lo Sauro, Edoardo Mannucci, Claudia Ravaldi, Francesco Rotella, Carlo Faravelli, Giovanni A. Fava, Sunil S. Bhar, Brett D. Thombs, Monica Pignotti, Marielle Bassel, Lisa Jewett, James C. Coyne, Aaron T. Beck, Femke Lamers, Catharina C.M. Jonkers, Hans Bosma, Gertrudis I.J.M. Kempen, Tomas Toft, Marianne Rosendal, Eva Ørnbøl, Frede Olesen, Lisbeth Frostholm, Per Fink, Jaap A.M.J. Meijer, Brenda W.J.H. Penninx, J. André Knottnerus, Jacques T.M. van Eijk, Valdo Ricca, Giovanni Castellini
Journal: Psychotherapy and Psychosomatics (2010)
OBSTETRICAL SOCIETY OF PHILADELPHIA.—STATED MEETING FRIDAY, JAN. 2,1885.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notes From the Field: Tuberculosis Cluster Associated With Homelessness—Duval County, Florida, 2004-2012
Journal: JAMA (2012)

Despite a decrease in incidence of tuberculosis (TB) in Duval County, Florida, from 102 cases (11.2 per 100,000 population) in 2008 to 71 cases (8.2 per 100,000) in 2011,* analysis of Mycobacterium tuberculosis genotyping data revealed a substantial increase in the percentage of TB cases with the same genotype.† That percentage increased from 27% (10 of 37) of genotyped cases in 2008 to 51% (30 of 59) of genotyped cases in 2011 (Florida Department of Health, unpublished data, 2012). During this period, the percentage of patients with this genotype who were homeless or who abused substances also increased. Because of concern over potential ongoing TB transmission involving these hard-to-reach populations, the Duval County Health Department, Florida Department of Health, and CDC conducted an investigation during February 15-March 13, 2012. As of March 13, review of medical records and interviews with TB patients had identified 99 cases related to the cluster based on matching genotype results and epidemiologic links (48 cases), matching genotype only (22), epidemiologic links only (22), or common social risk factors for TB (e.g., homelessness, incarceration, or substance abuse within 1 year of TB diagnosis) and suspected epidemiologic links (seven). The first known case with a matching genotype occurred in 2004.
Mortality from ischemic heart disease. Changes in middle-aged men since 1900
Authors: T. W. Anderson
Journal: JAMA (1973)

There has been a large and unequivocal rise in the death rate from ischemic heart disease in middle-aged US white men since the beginning of this century. Uncertainty caused by changing terminology has been minimized by working with the ratio of the male to female death rates. In the age group 45 to 64, the ratio of the male to female death rates from all types of heart disease rose from 1.1 in 1920 to 3.3 in 1968. By 1968 the all-cause male death rate had risen to more than double the female rate (ratio 2:1) compared to only a 10% male excess in 1920.
Immunohematologic diseases
Authors: L. J. Rosenwasser
Journal: JAMA (1992)

TWO EVENTS revolutionized the field of immunohematology: the discovery of the ABO blood group system by Karl Landsteiner in 1900 and the development of the Coombs' test in 1945. These observations resulted in the improved safety and success of blood transfusions. Approximately 2% of hospitalized patients develop alloantibodies that are formed as a result of blood transfusions from heterologous donors or during pregnancy; this can lead to transfusion reactions or hemolytic disease of the newborn. Although it was initially thought that alloantibodies are formed only against erythrocyte antigens, it became evident that alloantibodies are also generated against various neutrophil (eg, NA1, NB1) and platelet (eg, P1<sup>A1</sup>, Bak<sup>a</sup>) antigens. Like erythrocyte alloantibodies, neutrophil and platelet alloantibodies can cause immune destruction of blood cells during transfusion reactions or pregnancy. Furthermore, immune destruction of erythrocytes, neutrophils, and platelets can occur when autoantibodies are produced against these cells, during drug therapy, or
Vitamin A supplementation and child mortality. A meta-analysis
Authors: W. W. Fawzi
Journal: JAMA (1993)

<h3>Objective.</h3> —A two-part meta-analysis of studies examining the relationship of vitamin A supplementation and child mortality. <h3>Data Sources.</h3> —We identified studies by searching the MEDLARS database from 1966 through 1992 and by scanning<i>Current Contents</i>and bibliographies of pertinent articles. <h3>Study Selection.</h3> —All 12 vitamin A controlled trials with data on mortality identified in the search were used in the analysis. <h3>Data Extraction.</h3> —Data were independently extracted by two investigators who also assessed the quality of each study using a previously described method. <h3>Data Synthesis.</h3> —We formally tested for heterogeneity across studies. We pooled studies using the Mantel-Haenszel and the DerSimonian and Laird methods and adjusted for the effect of cluster assignment of treatment groups in community-based studies. Vitamin A supplementation to hospitalized measles patients was highly protective against mortality (DerSimonian and Laird odds ratio, 0.39; 95% confidence interval, 0.22 to 0.66;<i>P</i>=.0004) (part 1 of the meta-analysis). Supplementation was also protective against overall mortality in community-based studies (DerSimonian and Laird odds ratio, 0.70; clustering-adjusted 95% confidence interval, 0.56 to 0.87;<i>P</i>=.001) (part 2 of the meta-analysis). <h3>Conclusions.</h3> —Vitamin A supplements are associated with a significant reduction in mortality when given periodically to children at the community level. Factors that affect the bioavailability of large doses of vitamin A need to be studied further. Vitamin A supplements should be given to all measles patients in developing countries whether or not they have symptoms of vitamin A deficiency. (<i>JAMA</i>. 1993;269:898-903)
THE DEETHERIZATION OF PATIENTS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Growth Factors And Wound Healing: Platelet-Derived Growth Factor As A Model Cytokine
Authors: T. Deuel
Journal: Annual Review of Medicine (1991)

Cytokines such as the platelet-derived growth factor (PDGF) have the potential to initiate and mediate many if not all of the complex biological responses associated with inflammation and wound healing. PDGF is a potent cytokine that may be used to illustrate the diverse activities initiated by the interactions of PDGF with its receptor relevant to the inflammatory response and subsequent wound repair. Because PDGF can chemotactically attract, activate, and initiate new expression of quiescent genes (e.g. the small inducible gene, SIG, family), it fulfills the predictions anticipated of a candidate wound hormone. PDGF added directly to experimental wounds in animals enhances wound healing, which suggests that cytokines will become increasingly important as therapeutic agents in the treatment of wounds in humans.
Health care delivery in the community. Use of available resources
Authors: B. L. Truscott
Journal: JAMA (1972)

Coordination and more effective use of available community health resources resulted in a more equitable access to better care for stroke patients in 19 predominantly rural counties in North Carolina. The almost 1 million people in these regions had access to community stroke programs involving 22 general hospitals (average bed capacity, 140), eight nursing homes, and one extended-care facility. The interdependent functions of existing health personnel and facilities form a health care delivery chain which offer the patient continuity of care. Evaluation of inhospital treatment of 178 prestroke program, and of 408 poststroke program cohorts illustrates that patterns of care can be improved promptly and economically. These concepts can be applied to the management of other disease categories in both urban and rural communities.
Hyperglucagonaemia and necrolytic migratory erythema in cirrhosis—possible pseudoglucagonoma syndrome *
Authors: JOHN A. DOYLE, ARNOLD L. SCHROETER, ROY S. ROGERS
Journal: British Journal of Dermatology (1979)

Necrolytic migratory erythema is the distinctive cutaneous eruption seen with glucagon-producing tumours of the pancreas. Recognition of this eruption is important because it may lead to the early diagnosis of a glucagonoma. Recently, we saw a patient who had necrolytic migratory erythema, hyperglucagonaemia, and cirrhosis of the liver with no evidence of pancreatic tumour while alive or at autopsy. Serum glucagon levels during the period of observation and during an oral glucose tolerance test suggested that the hyperglucagonaemia was not due to an occult glucagon-producing tumour but may have been the result of advanced hepatic cirrhosis.
The 12-gene colon cancer assay validation and utility: Summary of clinical evidence.
Authors: Emily Burke, Haluk Tezcan, Margarita Lopatin, Kim Michelle Clark-Langone, Mark Lee, Steven Shak, Amy Pratt Sing
Journal: Journal of Clinical Oncology (2014)

523 Background: The 12-gene colon cancer assay is the first commercially available molecular assay to predict the risk of recurrence in stage II/III colon and rectal cancer. Rigorous evidence for clinical validity and utility of an assay is imperative since the result is used for treatment decision-making. This summary outlines the studies that meet an established definition of clinical validation and additional studies that support the utility of the assay. Methods: Prospectively designed studies using archival tissue with pre-specified methods, clinical outcomes, and analysis plan were considered clinical validation studies (Simon et al. JNCI 2009). Additional studies that demonstrated the utility of the assay in a clinical setting were considered supportive. Results: The assay has been clinically validated in four independent studies with 3315 patients (2390 stage II/628 stage III colon and 130 stage II/167 stage III rectal). All four studies demonstrated a significant association (p&lt;0.05) between the result and outcome (e.g. recurrence risk and cancer specific survival). The score was examined in the context of other variables, including T and N stage, MMR status, number of nodes examined, lymphovascular invasion, and tumor grade; across all studies, the result consistently contributed to risk stratification beyond these variables. Three clinical utility studies with 502 patients showed that 29-45% of initial treatment recommendations in stage IIA colon cancer were changed, with a net reduction in use of adjuvant chemotherapy. Conclusions: Clinical validation of the 12-gene assay followed a now-standard approach of using archived tissue from multiple large, prospectively-designed studies with documented long-term outcomes; the 12-gene colon assay meets level IB evidence criteria. Subsequent studies showed the assay has impact on clinical practice. The underlying tumor biology assessed by the score is relevant in both colon (stage II and III) and rectal cancer, providing information beyond conventional features, and can help guide treatment decisions regarding adjuvant chemotherapy.
Leads from the MMWR. Oral contraceptive use and the risk of breast cancer in young women
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Late protection against chemical induced liver injury with dimethyl sulfoxide , Dept. of Anesthesiology, University of Arizona, Tucson, AZ
Journal: Hepatology (1995)

The etiology of chronic bile duct injury and fibrosis in patients with autoimmune cholestatic liver diseases is complex, and likely involves immune cells such as lymphocytes. However, most models of biliary fibrosis are not autoimmune in nature. Biliary fibrosis can be induced experimentally by prolonged exposure of mice to the bile duct toxicant alpha-naphthylisothiocyanate (ANIT). We determined whether lymphocytes contributed to ANIT-mediated biliary hyperplasia and fibrosis in mice. Hepatic accumulation of T-lymphocytes and increased serum levels of anti-nuclear-autoantibodies were evident in wild-type mice exposed to ANIT (0.05% ANIT in chow). This occurred alongside bile duct hyperplasia and biliary fibrosis. To assess the role of lymphocytes in ANIT-induced biliary fibrosis, we utilized RAG1−/− mice, which lack T- and B-lymphocytes. ANIT-induced bile duct injury, indicated by increased serum alkaline phosphatase activity, was reduced in ANIT-exposed RAG1−/− mice compared to ANIT-exposed wild-type mice. Despite this reduction in biliary injury, ANIT-induced bile duct hyperplasia was similar in wild-type and RAG1−/− mice. However, hepatic induction of profibrogenic genes including COL1A1, ITGβ6 and TGFβ2 was markedly attenuated in ANIT-exposed RAG1−/− mice compared to ANIT-exposed wild-type mice. Peribiliary collagen deposition was also reduced in ANIT-exposed RAG1−/− mice. The results indicate that lymphocytes exacerbate bile duct injury and fibrosis in ANIT-exposed mice without impacting bile duct hyperplasia.