tbuckley/cabot-search huggingface dataset:
Response
Authors: ØYSTEIN FODSTAD, INGE KJØNNIKSEN
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Response Get access ØYSTEIN FODSTAD, ØYSTEIN FODSTAD Search for other works by this author on: Oxford Academic PubMed Google Scholar INGE KJØNNIKSEN INGE KJØNNIKSEN Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 12, 20 June 1990, Page 1070, https://doi.org/10.1093/jnci/82.12.1070 Published: 20 June 1990
Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes*1
Authors: H AMOUZADEH
Journal: Hepatology (1995)

In this study we have investigated the mechanism of the processing of trifluoroacetylated liver microsomal protein antigens associated with halothane hepatitis to learn how the immune system might come in contact with these proteins to form antibodies directed against them. Rats were treated with halothane and parenchymal (PC) and non-parenchymal cells (NPC) were isolated 16 hours later. Immunoblotting of the cell lysates with antisera directed against the trifluoroacetyl hapten showed the presence of high levels of trifluoroacetylated proteins in parenchymal cells, whereas none of these proteins were detected in endothelial or Kupffer cells that were isolated by centrifugal elutriation. The half-lives of 100-, 82-, 80-, 63-, 59-, 58-, and 57-kd trifluoroacetylated and native carrier proteins of the trifluoroacetyl hapten in cultures of rat primary parenchymal cells were approximately 1 day. The turnovers of all of these trifluoroacetylated proteins, except for that of the trifluoroacetylated 100-kd protein, were inhibited by treatment of the cells with ammonium chloride, leupeptin, 4-(2-aminoethyl)-benzenesulfonyl fluoride, or 3-methyladenine (3-MA). These results indicate that, in liver, the major source of the formation of trifluoroacetylated antigens associated with halothane hepatitis is the parenchymal cells. It appears that most of the trifluoroacetylated antigens and possibly the native carrier protein of the trifluoroacetyl haptens are transferred from the endoplasmic reticulum (ER) to an acidic compartment of PCs, where they are enzymatically degraded. The processing of the trifluoroacetylated proteins by this pathway may be a protective mechanism that prevents these covalently altered proteins from inducing an antibody response in most patients who are administered halothane.
Cholesterol supplementation prevents necrosis and inflammation but enhances fibrosis in alcoholic liver disease in the rat
Authors: A Nanji
Journal: Hepatology (1997)

Based on studies that show a role for the low-density lipoprotein (LDL)-receptor in arachidonic acid delivery and eicosanoid synthesis in macrophages, the present study investigated the effect of cholesterol supplementation on pathological changes and thromboxane (TX) synthesis in alcoholic liver injury. Male Wistar rats were intragastrically fed ethanol with either corn oil or fish oil for 1 month. Control rats received isocaloric amounts of dextrose instead of ethanol. An additional group of rats fed either ethanol or dextrose with fish oil or corn oil were supplemented with 1% cholesterol. At the time of killing, all rats had the following evaluated: liver histopathology, lipid peroxidation, liver and plasma thromboxane levels, plasma endotoxin and messenger RNA (mRNA) levels of LDL-receptor, tumor necrosis factor α (TNF-α), cyclooxygenase (Cox)-1 and -2, and transforming growth factor β (TGF-β). Rats fed ethanol with either fish oil or corn oil developed fatty liver, necrosis, inflammation, and central vein collagen deposition. Cholesterol supplementation enhanced the degree of fibrosis but prevented necrosis and inflammation. These alterations in pathological changes by cholesterol were accompanied by absent TNF-α and Cox-2 mRNAs, decreased thromboxane levels, decreased lipid peroxidation, and increased TGF-β mRNA. Cholesterol enrichment of the diet thus decreases proinflammatory components, but enhances fibrosis in ethanol-fed rats.
Convulsive Disorders and Participation in Sports and Physical Education
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pitfalls in the recognition of subarachnoid hemorrhage
Authors: H. P. Adams
Journal: JAMA (1980)

Between January 1970 and January 1978, one hundred eighty-two patients were admitted to the University of Iowa Hospitals for treatment of subarachnoid hemorrhages secondary to a ruptured aneurysm. The correct diagnosis had been delayed in 41 patients, with most treated from four to seven days before the correct diagnosis was established. Generally, these patients were initially less acutely ill than those patients whose conditions were promptly diagnosed. The most common misdiagnoses were systemic infectious illnesses, migraine headache, and hypertensive encephalopathy. Rebleeding occurred in three patients before the correct diagnosis was made. Atypical symptoms, problems in diagnosis, and the need for prompt therapy are reviewed. (<i>JAMA</i>244:794-796, 1980)
Council on Pharmacy and Chemistry
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short-Term Effect of Ozone on the Pulmonary Function of Children in Primary School
Authors: Pau-Chung Chen, Yu-Min Lai, Chang-Chuan Chan, Jing-Shiang Hwang, Chun-Yuh Yang, Jung-Der Wang
Journal: Environmental Health Perspectives (1999)

The objective of this study was to evaluate the short-term effect of ambient air pollution on the pulmonary function of schoolchildren. We sampled 941 children in primary school in three communities in Taiwan (Sanchun, Taihsi, and Linyuan). The nearby stations of the Taiwan air quality monitoring network provided the hourly ambient concentrations of sulfur dioxide, carbon monoxide, ozone, particulate matter < or = to 10 microm in aerodynamic diameter, and nitrogen dioxide. Spirometry was performed once for each sampled child. We also obtained the status of indoor air pollution and chronic respiratory disease history by using a structured questionnaire. Multivariate linear model analysis was used to evaluate pulmonary function effects of each pollutant in addition to determinants of indoor air pollution and meteorologic conditions. We found a significantly negative association of peak O(3) concentration on the day before spirometry with individual forced vital capacity and forced expiratory volume in 1 sec. The decrease in children's lung function can occur at peak hourly O(3) concentrations < 80 ppb. The slope of lung function decrease for Taiwanese children is approximately 1 mL/ppb for peak hourly O(3) exposure.
Mindful art
Authors: Lambros Malafouris
Journal: Behavioral and Brain Sciences (2013)

Abstract Bullot &amp; Reber (B&amp;R) begin asking if the study of the mind's inner life can provide a foundation for a science of art. Clearly there are many epistemological problems involved in the study of the cognitive and affective basis of art appreciation. I argue that context is key. I also propose that as long as the “mind's life” continues to be perceived as an “inner” intracranial phenomenon, little progress can be made. Mind and art are one.
History of the Great War Based on Official Documents.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction to: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1
Authors: Xin Xia, Xixi Li, Fanying Li, Xujia Wu, Maolei Zhang, Huangkai Zhou, Nunu Huang, Xuesong Yang, Feizhe Xiao, Dawei Liu, Lixuan Yang, Nu Zhang
Journal: Molecular Cancer (2019)

In the published article [1], an error was noticed in Fig. 6B. The western blot results were reversed between the overexpression group and the knockdown group of circ-AKT3. The corrected and updated Fig. 6 is provided below. This error does not affect the findings or conclusions of the article.
Addition of Cyclophosphamide and Higher Doses of Dexamethasone Do Not Improve Outcomes of Patients with AL Amyloidosis Treated with Bortezomib
Authors: Efstathios Kastritis, Maria Gavriatopoulou, Maria Roussou, Despina Fotiou, Dimitrios Ziogas, Magdalini Migkou, Evangelos Eleutherakis-Papaiakovou, Ioannis Panagiotidis, Erasmia Psimenou, Elektra Papadopoulou, Constantinos Pamboucas, Efstathios Manios, Harikleia Gakiopoulou, Anna Tasidou, Stavroula Giannouli, Evangelos Terpos, Meletios A Dimopoulos
Journal: Blood (2016)
Tropical paradox: nutrition in the Caribbean
Authors: M. Korcok
Journal: JAMA (1983)

The 13 English-speaking Caribbean nations recently reported an "epidemic" of adult obesity, accompanied by dramatic increases in diabetes and hypertension. At the same time, these nations—with a population of more than 5 million—continue to be plagued by undernutrition, particularly among children, pointing out how complex the problems of nutrition planning in developing countries can be. Speaking to the Seventh Western Hemisphere Nutrition Congress held recently in Miami Beach, the Honorable Billie Antoinette Miller, Minister of Education of Barbados (and former Minister of Health), explained that this apparent anomaly has come about as the nations moved from poor "cane field," or solely agricultural, economies into the relative affluence of light industry and tourism—life-styles requiring lower energy output but encouraging higher caloric intake. A recent Caribbean nations' health survey showed that one of every 17 persons has a history of diabetes, Miller noted, "suggesting that there are probably over 200,000 diabetics in
DIPLOCOCCUS SEPTICEMIA SIMULATING TYPHOID.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Issue Highlights
Journal: Circulation (2007)

In this week's issue of Circulation, Pape et al use data from the International Registry of Acute Aortic Dissection (IRAD) to investigate the relationship between aortic diameter and type A dissection.The investigators examined 591 type A dissection patients between 1996 and 2005 and found that nearly 60% of those evaluated had diameters Ͻ5.5 cm and that 40% had diameters Ͻ5.0 cm.Therefore, the authors concluded that the majority of patients with acute type A aortic dissection present with aortic diameters Ͻ5.5 cm and do not fall within current guidelines for elective aneurysm surgery.Although descriptive, this study suggests that alternatives to aortic size need to be assessed as predictors for identifying patients at risk for aortic dissection.See p 1120.
Cadwallader Colden (1688-1776)
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book: HIV
Authors: R. Colebunders
Journal: BMJ (2001)

Education and debate p 422 Eds Howard Libman, Harvey J Makadon ACP-ASIM, £22, pp 250 ISBN 0943126 84 3 Rating: ![Graphic][1]</img> ![Graphic][2]</img> The clinical management of people infected with HIV has evolved dramatically over the past few years. Only a few years ago, HIV infection was a progressive disease characterised by recurrent opportunistic infections and with a high incidence of malignancies such as non-Hodgkin's lymphoma and Kaposi's sarcoma. Now, with the availability of highly active antiretroviral … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in the Middle East
Authors: Atefeh Amouzegar, Ali K. Abu-Alfa, Mona N. Alrukhaimi, Aminu K. Bello, Mohammad A. Ghnaimat, David W. Johnson, Vivekanand Jha, David C.H. Harris, Adeera Levin, Marcello Tonelli, Meaghan Lunney, Syed Saad, Maryam Khan, Deenaz Zaidi, Mohamed A. Osman, Feng Ye, Ikechi G. Okpechi, Shahrzad Ossareh
Journal: Kidney International Supplements (2021)
Biomarkers of Carcinogen Exposure and Cancer Risk in a Coke Plant
Authors: Giorgio Assennato, Giovanni M. Ferri, Melvin S. Tockman, Miriam C. Poirier, B. Schoket, Antonio Porro, Vincenzo Corrado, Paul T. Strickland
Journal: Environmental Health Perspectives (1993)

To evaluate the association between an indicator of carcinogen exposure (peripheral blood leukocyte DNA adducts of polycyclic aromatic hydrocarbons) and an early indicator of neoplastic transformation (sputum epithelial cell membrane antigens binding by monoclonal antibodies against small cell lung cancer and against nonsmall cell lung cancer), a survey of 350 coke-oven workers and 100 unexposed workers was planned. This paper reports a pilot investigation on a subgroup of 23 coke-oven workers and 8 unexposed controls. A "gas regulator" worker with positive tumor antigen binding was identified. Results show that smokers, subjects with decreased pulmonary function (forced expiratory volume in 1 sec/forced vital capacity% < 80), and those with morphological dysplasia of sputum cells have higher levels of DNA adducts. The gas regulators showed the highest values for adducts; however, no significant difference of adduct levels was found between the coke-oven group and unexposed controls.
Infant birth weight and smoking reduction
Authors: K. Goldin
Journal: JAMA (1993)

<h3>In Reply.</h3> —We certainly concur that ORT is an effective, safe, well-recognized, proven, and economical method of treating acute GE in infants and young children. It was not the purpose of my presentation to discuss in detail various methods of therapy. Rather, the goal was to present highlights of our research program on viral GE and to give an overview regarding its etiology, epidemiology, clinical manifestations, treatment, and prevention. The case presented was drawn from one of 72 hospitalized infants and young children included in a 1977 publication that described the clinical features of rotavirus GE.<sup>1</sup>The case was not intended to set a standard for therapy of viral GE, but was presented as an example of a patient with acute GE associated with rotavirus infection as determined by virologic and serologic assays. In the "Prophylaxis and Treatment" section of this Grand Rounds, we described the treatment as follows:
PTU-164 Evidence Of Two Aetiologies Of Gastroesophageal Junctional Cancers Based On Gastric Parietal Cell Density
Authors: MH Derakhshan, T Harvey, R Ferrier, EV Robertson, C Orange, M Forshaw, JJ Going, KE McColl
Journal: Gut (2014)

<h3>Introduction</h3> Serum pepsinogen I:II ratio, a surrogate marker of atrophic gastritis, suggests that some adenocarcinomas at the gastroesophageal junction (GOJ) develop on a background of atrophic gastritis, similar to non-cardia gastric cancer, while others arise on a backgrounds of healthy, non-atrophic gastric mucosa similar to oesophageal adenocarcinoma. In this current study, we have directly the background gastric body mucosa in patients with junctional adenocarcinomas compared to oesophageal adenocarcinomas and non-cardia gastric cancers. <h3>Methods</h3> 127 gastrectomy and oesophagectomy specimens for adenocarcinoma were identified for which clear topographic description allowed assignment to oesophageal, junctional (including cardia) and gastric non-cardia locations. In these gastric body mucosa specimens, well clear of the tumour margin, parietal cells were immunostained using anti- H<sup>+</sup>/K<sup>+</sup> ATPase. Parietal cell density was counted in 3 to 5 well-oriented fields (1 mm<sup>2</sup> each) and expressed as mean parietal cell number per 1 mm<sup>2</sup> area. Total mucosal thickness, glandular thickness, intestinal metaplasia, inflammation indicated by polymorphonuclear (PMN) and mononuclear (MN) cells and reactive atypia (RA) were also scored. Non-parametric statistics were used to compare distributions. <h3>Results</h3> Ten (8%) cases lacked well-orientated blocks of body mucosa. The remaining 117 patients included 34 oesophageal, 52 GOJ and 31 non-cardia gastric adenocarcinomas. Median (IQR) parietal cell densities were 836 (173), 602 (389) and 411 (334) per mm<sup>2</sup> in gastric mucosa of oesophageal, GOJ and gastric cancers, respectively (all differences P &lt; 0.001). Using a parietal cell density of 630/mm<sup>2</sup>, 85% of oesophageal adenocarcinomas had a higher and 84% of non-cardia gastric cancers had a lower values. With the same cut-off, 50% of GOJ adenocarcinomas were gastric and remaining was oesophageal in origin. Glandular mucosa was thicker in patients with GOJ cancer compared to gastric (0.735 vs. 0.600, p = 0.005) and thinner than oesophageal cancer (0.735 vs. 0.900, p &lt; 0.001). Inflammatory scores in GOJ cancers were lower than in gastric cancer and higher than in oesophageal cancer. <h3>Conclusion</h3> This study provides direct evidence for marked differences in the gastric mucosal phenotype in the patients with oesophageal versus gastric non-cardia cancer, with the former being healthy and uninflamed, but the latter atrophic and inflamed. The background gastric mucosa of GOJ cancer supported them being two distinct aetiologies, one group resembling oesophageal adenocarcinoma and other gastric non-cardia cancer. <h3>Disclosure of Interest</h3> None Declared.
North Carolina's maternal health campaign ignores smoking, maternal health advocates fume
Authors: A. A. Skolnick
Journal: JAMA (1991)

A NUMBER of maternal and child health advocates say they are outraged over educational materials put out by North Carolina's campaign to reduce infant mortality. These critics say that, while the brochures and posters warn women about alcohol, illicit drugs, and other dangers to a healthy pregnancy, warnings about the hazards of smoking are conspicuously absent. The educational material was produced by North Carolina's Drug Cabinet and the state's "First Step" Campaign, a coalition of state agencies and private groups working to reduce North Carolina's very high infant mortality rate. According to critics, the chair of the Drug Cabinet, North Carolina's lieutenant governor, James C. Gardner, is responsible for the omission. However, the lieutenant governor denies that so-called tobacco politics has anything to do with the decision not to include information about the fetal and maternal health effects of smoking. He insists that the brochures and posters were meant to