tbuckley/cabot-search huggingface dataset:
QOLP-13. IMPACT OF CANNABIS USE ON QUALITY OF LIFE IN PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMORS
Authors: Eduardo Rodriguez Almaraz, Nicholas Butowski, Susan Chang, Nancy Ann Oberheim-Bush, Jennifer Clarke, Jennie Taylor, Robin Buerki, Mitchel Berger
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Nearly 80,000 new cases of primary brain tumors are expected to be diagnosed this year, 32% of CNS tumors are malignant. Anecdotally, patients who report use of cannabis, frequently describe higher quality of life scores (QOL) in standardized instruments. However, the lack of available tools that allow systematic documentation of cannabis use results in a barrier to accurately assess efficacy, potential benefits and risks. METHODS We conducted a single center, observational study: patients with primary brain tumors answered a previously validated instrument to explore cannabis use. QOL was assessed using the instruments from the European Organisation for Research and Treatment of Cancer: QLQ-C30 and its complementary module BN-20 as well as the EuroQol instrument EQ-5D-5L. Eligible participants were identified as cannabis users or non-users, completing the instruments in a self-administered fashion. RESULTS To date, 51 patients who signed informed consent were enrolled and answered the questionnaires, mean age was 51 (SD 12.95) years, 34 were male, 30 were considered active cannabis users (66.6% males and 33.3% females). The mean global health score in the QLQ-C30 instrument was 68.4 (SD: 20.7) among cannabis users and 82.2 (SD: 17.5) among non-users. The mean difference in QOL scores between users and non-users was 13.8 (95%CI: 2.8, 24.8; p=0.01). In contrast the difference between cannabis users and non-users in QOL index in the EQ-5D-5L instrument was 0.13 (95% CI: 0.06, 0.2; p=0.001). Among cannabis users, patients perceive their symptoms as moderate before using cannabis and mild after using cannabis (p &gt;0.001) CONCLUSIONS In our analysis, patients who use cannabis reported, on average, lower QOL scores. Potentially, sicker patients resort to cannabis to improve their symptoms and ultimately quality of life. The perception of patients is that cannabis usage improves overall quality of life. Findings provide support to perform prospective studies.
RT-qPCR and RT-Digital PCR: A Comparison of Different Platforms for the Evaluation of Residual Disease in Chronic Myeloid Leukaemia
Authors: Mary Alikian, Alexandra S. Whale, Simon Cowen, Kim Piechocki, Michael John Griffiths, Alistair G Reid, Susanna Akiki, Jane F. Apperley, Jim F. Huggett, Letizia Foroni
Journal: Blood (2016)
Correction to: Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data
Authors: Nelly Olova, Felix Krueger, Simon Andrews, David Oxley, Rebecca V. Berrens, Miguel R. Branco, Wolf Reik
Journal: Genome biology (2019)

Following publication of the original article [1], it was reported that the incorrect "Additional file 3" was published. The correct additional file is given below.
Occupational Injury Deaths—United States, 1980-1989
Journal: JAMA (1994)

During 1980-1989, 63,589 workers died from occupational injuries, an average of 17 deaths per day. CDC's National Institute for Occupational Safety and Health (NIOSH) monitors occupational injury deaths through the National Traumatic Occupational Fatalities (NTOF) surveillance system. This report summarizes occupational injury deaths compiled by NTOF* for 1980-1989.
Antineoplastons: The Controversy Continues
Authors: Stanislaw Burzynski
Journal: JAMA (1993)

<h3>To the Editor.</h3> —As a paid consultant to those formerly in litigation against me, Dr Green<sup>1</sup>can scarcely be considered impartial. Not surprisingly, Green gravely misrepresents more than 20 years of research. Due to space constraints, I can address only a few of Green's misstatements, and therefore am unable to counter one of the most serious problems of the article, Green's omission of dozens of publications. Green disputes my claim to a PhD degree in biochemistry and asserts that my bibliography does not identify a dissertation. The sworn affidavit of Professor Zdzislaw Kleinrok, president of the Medical Academy of Lublin, Poland, confirms that my PhD in biochemistry was awarded on October 16,1968. My doctoral dissertation<sup>2</sup>is always listed in my bibliography. Green refers to tests done by the National Cancer Institute (NCI) as "compelling evidence of the lack of efficacy of antineoplastons against experimental cancer." Green fails to
Student activism
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Section 50.—Acromegaly
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stuart Hishon
Journal: BMJ (2005)

A pioneer of open heart surgeryBill Cleland was one of the surgeons who developed open heart surgery in London in the late 1950s.He was at Hammersmith Hospital in 1952-3 when Professor Dennis Melrose developed the first heart-lung machine.Melrose and Cleland conducted extensive animal tests before trying the machine in 1953 on patients whose prognosis was poor.In the early days there were postoperative deaths, which taught them the importance of meticulous postoperative care, and the clinical programme was restarted successfully in 1957.Cleland was one of the machine's earliest users, and it enabled him to perform a wide range of new operations, specialising in mitral valvotomy, the surgical treatment of ventricular septal defect, and aortic valve replacement.He was the first to operate on the newly identified condition of obstructive cardiomyopathy-known in the United States as hypertrophic subaortic stenosisby excising muscle from the interventricular septum via the aortic valve.Russian surgeons were impressed by Melrose's heart-lung machine, and Professor Aleksandr Bakulev from the then Soviet Union bought one; he then invited the Hammersmith team to operate in Moscow in May 1959.It was at the height of the cold war and they were the first foreign doctors to perform surgery there.Melrose, Cleland, and another surgeon, Hugh Bentall, went.The Russians chose two adults and four children with congenital heart defects.Two of them had Fallot's tetralogy, which Cleland and his colleagues had never operated on before.All six operations were successful.Cleland remarked that this was helped by God, who had so little to do in Russia that he was able to give the children his undivided attention.The trip was a success in other ways.Cleland took his cine camera and filmed the army parade in Red Square, and was astonished not to be arrested.The team then returned on the inaugural UK flight of the Tupolev 104, the Soviet Union's first jet powered passenger airliner.Cleland was a meticulous surgeon, possessed of great energy, and a great teacher.He was warm hearted, and remained calm in emergencies.He was
Prognostic impact of the cumulative dose and dose intensity of everolimus in patients with pancreatic neuroendocrine tumors (PNETs)
Authors: R. Berardi, M. Torniai, S. Pusceddu, F. Spada, T. Ibrahim, C. Zichi, L. Antonuzzo, P. Ferolla, M. Rinzivillo, N. Silvestris, S. Partelli, B. Ferretti, A. Bongiovanni, L. Giustini, F. Di Costanzo, G. Delle Fave, N. Fazio, F.G.M. De Braud, M. Falconi, S. Cascinu
Journal: Annals of Oncology (2016)
Elbow disorders.
Authors: W. E. Tucker
Journal: BMJ (1969)

splitting of the finger-nails provided me with a clue to the diagnosis in these cases.The coexistence of nail changes and a raised serum uric acid in 19 cases would appear to suggest that reeding and splitting and brittle- ness, either individually or together, may be a frequent physical sign in hyperuricaemia and might warrant further investigation-I am, etc.,
Error in Table
Journal: JAMA Dermatology (2015)

Murad Alam, MD, MSCI; Rohit Kakar, MD; Michael Nodzenski, BA; Omer Ibrahim, MD; Wareeporn Disphanurat, MD; Diana Bolotin, MD, PhD; Judy H. Borovicka, MD; Natalie Pace, BS; Tina S. Alster, MD; Kenneth A. Arndt, MD; Kenneth R. Beer, MD; Joshua M. Berlin, MD; Leonard J. Bernstein, MD; Lori A. Brightman, MD; Kimberly Butterwick, MD; Sue Ellen Cox, MD; Vera Chotzen, MD; Sabrina G. Fabi, MD; Richard E. Fitzpatrick, MD; Roy G. Geronemus, MD; Mitchel P. Goldman, MD; William F. Groff, DO; Michael S. Kaminer, MD; Suzanne Kilmer, MD; Thomas E. Rohrer, MD; Elizabeth L. Tanzi, MD; Susan K. Silva, MD; Simon S. Yoo, MD; Susan H. Weinkle, MD; John Strasswimmer, MD, PhD; Emily Poon, PhD; Jeffrey S. Dover, MD, FRCPC
SHAW ON THE OPSONIC INDEX.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply to Luca Boeri and Emanuele Montanari's Letter to the Editor re: Guido Giusti, Silvia Proietti, Moises E. Rodríguez-Socarrás, et al. Simultaneous Bilateral Endoscopic Surgery (SBES) for Patients with Bilateral Upper Tract Urolithiasis: Technique and Outcomes. Eur Urol 2018;74:810–5
Authors: Guido Giusti, Silvia Proietti, Moises E. Rodríguez-Socarrás, Brian H. Eisner
Journal: European Urology (2019)
This Week in JAMA
Journal: JAMA (2001)

A Piece of My Mind"Sickness is pungent, and memory clings to smells in the hospital."From "The Most Primitive Sense." SEE PAGE 766 Medical News & PerspectivesBehavioral researchers recommend that control strategies to decrease ecstasy use among young people focus on improving harm reduction rather than expanding law enforcement efforts. SEE PAGE 777 FDA Risk ManagementAnalysis of claims data indicates that risk management efforts by the US Food and Drug Administration (FDA) failed to achieve adequate rates of liver enzyme testing among patients using troglitazone.
Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6
Authors: Fabiana S. Machado, Lísia Esper, Alexandra Dias, Rajat Madan, YuanYuan Gu, David Hildeman, Charles N. Serhan, Christopher L. Karp, Júlio Aliberti
Journal: The Journal of Experimental Medicine (2009)
Abstract 166: Anti-cachectic Role of Neuregulin-1β in Heart Failure
Authors: Cristi L Galindo, Manisha Gupte, Oleg Y Tikhomirov, Pranay Manda, John H Cleator, Abigail Murphy, Ehab Kasasbeh, Douglas B Sawyer
Journal: Circulation Research (2017)

Neuregulin-1β (NRG-1β) is a growth and differentiation factor with pleiotropic systemic effects. Because NRG-1β has therapeutic potential for heart failure and known growth effects in skeletal muscle, we hypothesized that it might affect heart failure-associated cachexia, a severe co-morbidity characterized by a loss of muscle mass. We therefore assessed NRG-1β’s effect on skeletal muscle gene expression in a swine model of heart failure using recombinant Glial Growth Factor 2 (USAN - cimaglermin alfa), a version of NRG-1β currently being tested in humans with systolic heart failure. Animals received one of two intravenous doses (0.67 or 2 mg/kg) of NRG-1β bi-weekly for 4 weeks, beginning one week after infarct. Skeletal muscle was collected at the time of euthanasia from the intercostal space and paired-end RNA sequencing performed. NRG-1β treatment altered expression of 583 transcripts including 242 transcripts altered at both doses. These included genes required for myofiber growth, maintenance and survival such as MYH3, MYHC, MYL6B, KY and HES1 . Importantly, NRG-1β altered the directionality of at least 85 genes associated with cachexia, including myostatin, which negatively regulates myoblast differentiation by down-regulating MyoD expression. Consistent with this, MyoD was increased in NRG-1β treated animals. In vitro experiments with myoblast cell lines confirmed that NRG-1β induces skeletal muscle differentiation with an absolute requirement for ERBB signaling on myoblast differentiation. These findings suggest a NRG-1β-mediated anti-atrophic, anti-cachexia effect that may provide additional benefits to this potential therapy in heart failure.
Physician Suicide
Authors: Herbert Rakatansky
Journal: New England Journal of Medicine (2005)

Kessler and colleagues (June 16 issue) 1 report a dramatic increase in the rate of psychiatric treatment within general medicine from 1990 to 2003.They mention competing demands, but it is important also to emphasize the increased complexity and cost of integrating psychiatric treatment into primary care.Recent data from our pharmacies at Denver Health underscore this burden on a public health care system.Of all prescriptions written by our general internal medicine providers in the first quarter of 2005, 15 of the top 75 (ranked according to volume) and 13 percent of the total pharmacy acquisition costs are for medicines used to treat depression, anxiety, sleep disorders, or psychosis.Because our patients have limited access to long-term mental health services, general internists must treat psychiatric illnesses outside their areas of expertise.Given that the clinician's plate is overfilled with complex medical care, it is no wonder Kessler et al. found that psychiatric treatment within general medicine was substandard.Evidence-based guidelines for generalists and increased psychiatric access for the severely mentally ill are two important potential solutions to this crisis.
Possible complication of chloroquine therapy
Authors: W. G. McDonald
Journal: JAMA (1967)

<h3>To the Editor:—</h3> I note in the QUESTIONS AND ANSWERS department (<b>200</b>:269, 1967) advice concerning the treatment of delirium tremens, wherein treatment with paraldehyde, chlorpromazine, and corticotropin is recommended. Experimental work done many years ago at the Public Health Service Hospital at Lexington, Ky, demonstrated quite conclusively that delirium tremens is best considered a withdrawal syndrome from sedative medication and treated as such with the use of pentobarbital. There have been numerous articles in the psychiatric literature outlining the procedure to be used and giving reference to the original articles.
Anesthesiology
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Livia
Authors: Joel Lazar
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Élastographie par échoendoscopie de petites lésions pancréatiques: une étude multicentrique
Journal: Endoscopy (2018)

Les lésions pancréatiques de moins de 15 mm regroupent un large groupe d’indication, adénocarcinomes (40 %), tumeurs endocrine, lésions bénignes. L’aspect échographique en B mode est souvent similaire, quelle que soit l’étiologie. Il est désormais possible d’avéluer la densité des tissus en utilisant un module d’élastographie intégré aux appareils d’échographie.
In Vivo Fate Tracing Studies Using the SCL Stem Cell Enhancer: Embryonic Hematopoietic Stem Cells Significantly Contribute to Adult Hematopoiesis.
Authors: Joachim R. Gothert, Sonja E. Gustin, Mark A. Hall, Anthony R. Green, Berthold Gottgens, David J. Izon, C. Glenn Begley
Journal: Blood (2004)
INSANITY AND DIVORCE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chest injuries
Authors: J. W. Love
Journal: JAMA (1975)

THORACIC injuries are seen in two broad categories: blunt trauma (also known as closed-chest injury) and penetrating trauma. The predominant type of injury likely to be seen in the emergency room depends on the patient population served. The large urban hospital, especially if it serves a ghetto area, will see a predominance of penetrating trauma. The smaller, more rural hospital, especially if it is near a highway, will see a predominance of blunt trauma. As might be expected, penetrating injuries associated with substantial organ involvement may require urgent treatment. Blunt trauma is often less urgent and more subtle. These two types of injuries will be considered separately. <h3>PENETRATING INJURIES</h3> Penetrating chest wounds generally are caused by knives and bullets. Experience has taught that the bulk of penetrating chest injuries, unlike penetrating abdominal injuries, can be managed without surgery. This implies that most of these injuries do not result in substantial