tbuckley/cabot-search huggingface dataset:
Doctor-Patient Communication
Authors: Howard Waitzkin
Journal: JAMA (1984)

Research in the social sciences has clarified the nature and problems of doctor-patient communication. The development of adequate communication skills is now a goal of training programs in the primary-care specialties. Social structural barriers impede effective communication, however, and information giving remains problematic. Doctors tend to underestimate patients' desire for information and to misperceive the process of information giving. The transmission of information is related to characteristics of patients (sex, education, social class, and prognosis), doctors (social-class background, income, and perception of patients' desire for information), and the clinical situation (number of patients seen). Doctors' nonverbal communication abilities are associated with outcomes of medical care such as satisfaction and compliance. Regarding the sociolinguistic structure of communication, doctors often maintain a style of high control, which involves many doctor-initiated questions, interruptions, and neglect of patients' "life world." Training programs and standards of clinical practice should emphasize that improved doctor-patient communication is both desirable and possible. (<i>JAMA</i>1984;252:2441-2446)
Management of foreign bodies in the esophagus
Authors: M. S. Kleinman
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumococcal immunization: from policy to practice
Authors: B. Schwartz
Journal: JAMA (1990)

The importance of<i>Streptococcus pneumoniae</i>as the leading cause of pneumonia requiring hospitalization and a major cause of death among the elderly and other high-risk populations is well documented.<sup>1,2</sup>For the past 12 years, the availability of pneumococcal vaccine has provided an opportunity to reduce substantially the morbidity and mortality of pneumococcal disease, an opportunity that has been largely unrealized. While the Immunization Practices Advisory Committee and other expert panels uniformly recommend pneumococcal immunization for high-risk populations, and have published increasingly inclusive recommendations in 1981, 1984, and 1989,<sup>3-5</sup>only 10% of the target population have been immunized<sup>6</sup>—a painful reminder of the limited impact of public health policy statements on medical practice. Explanations offered for the low utilization of vaccines targeted for adults include a lack of emphasis on preventive care within the medical community, uncertainty among physicians concerning the high-risk conditions for which immunization is recommended, unfounded concerns
La cesárea extraperitoneal y LA TRANSPERITONEAL suprasinfisaria SUS MODALIDADES técnicas y SUS FINALIDADES terapéuticas.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vasily Aksyonov
Authors: B. Lichterman
Journal: BMJ (2009)

<h3>OBJECTIVE</h3> To elucidate possible roles of several transcription factors in the pathogenesis of rheumatoid arthritis (RA), the transcription factor expression in RA synovial tissue and their contribution to RA synovial cell functions were studied. <h3>METHODS</h3> Single cell suspension of dissociated synovial tissue was cultured to induce in vitro tissue outgrowth of RA synovial cells. Transcription factors were immunohistochemically identified in RA synovial tissue obtained by joint surgery and in the in vitro tissue outgrowth, and confirmed by western blotting and gel shift assays. <h3>RESULTS</h3> Immunohistochemical examination of RA synovial tissue revealed simultaneous expression of various transcription factors (NF-κB, c-Jun (a component of AP-1), cAMP responsive element binding protein (CREB), and OCT-1). The same set of transcription factors was expressed in the in vitro tissue outgrowth of RA patients. The early passage RA synovial cells were treated with interleukin 1β (IL1β) and confirmed translocation of transcription factors into the nucleus by western blotting, and their DNA binding activity by gel shift assays. <h3>CONCLUSION</h3> This study emphasises the importance of the simultaneous expression of several transcription factors for the hyperactivity of RA synovial cells that leads to tissue outgrowth.
<i>QuickStats:</i> Death Rates* for Motor Vehicle Traffic Injury,† by Age Group — National Vital Statistics System, United States, 2015 and 2017
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

34 35-54 55-74 ≥75 Deaths per 100,000 population in age group Age group (yrs) * Rates are deaths per 100,000 population in specified age group.† Motor vehicle traffic injuries are identified as underlying cause of death with International Classification of Diseases, Tenth Revision (ICD-10) codes V02-V04 (.1,.9), V09.2,V12-V14 (.3-.9), V19 (.4-.6), V20-V28 (.3-.9), V29-V79 (.4-.9), V80 (.3-.5), V81.1, V82.1, V83-V86 (.0-.3), V87 (.0-.8), and V89.2.From 2015 to 2017, death rates for motor vehicle traffic injury increased for persons aged ≥15 years.For infants and children aged <15 years there was no statistically significant change from 2015 to 2017, and this group had the lowest death rate (2.0 deaths per 100,000) in 2017.The highest death rate in 2017 was for persons aged ≥75 years (19.1),followed by a 15.3 death rate for persons aged 15-34 years, and 12.8 for persons aged 35-54 and 55-74 years.
On Porrigo
Authors: R. W. Dunn
Journal: BMJ (1863)

Two cases of growths from the free borders of the true cords, one very much elongated and detached spon.taneously.Four cases of growths from the superior surfaces of the true cords, but in one involving the false as well.Tlhree cases of irregular destructive ulceration of the true vocal cords.A case of variolous destruction of the right vocal cord.Three cases of tuberculous ulceration of the wholb larynx, with destruction of tissue.A case of supraglottic cedema, with perforating ulcer of velum palati.A. case of elephantiasis of the throat and larynx.A case of phlebectasis laryngea, and paralysis of the triue cords from old inflammation.Scven cases of pendency of the epiglottis, witlh a tu- mourl posteriorly in one.Eiglht cases of malformation and deformity of the epi- glottis.Two cases of malformation of the larynx in the deaf and dumb.A case of paralysis of the larynx after diphtheria.A case of supposed aortic aneurism pressing upon the trachea.
Late Postoperative Aspiration Syndrome
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Research Resource: Estrogen-Driven Prolactin-Mediated Gene-Expression Networks in Hormone-Induced Prostatic Intraepithelial Neoplasia
Authors: Neville N.C. Tam, Carol Y.Y. Szeto, Johannes M. Freudenberg, Amy N. Fullenkamp, Mario Medvedovic, Shuk-Mei Ho
Journal: Endocrine Reviews (2010)

Cotreatment with testosterone (T) and 17β-estradiol (E2) is an established regimen for inducing of prostatic intraepithelial neoplasia (PIN) and prostate cancer in rodent models. We previously used the pure antiestrogen ICI 182,780 (ICI) and bromocriptine, a dopamine receptor agonist, to inhibit PIN induction and systemic hyperprolactinemia in Noble rats and found that the carcinogenic action of T+E2 is mediated directly by the effects of E2 on the prostate and/or indirectly via E2-induced hyperprolactinemia. In this study, we delineate the specific action(s) of E2 and prolactin (PRL) in early prostate carcinogenesis by an integrated approach combining global transcription profiling, gene ontology, and gene-network mapping. We identified 2504 differentially expressed genes in the T+E2-treated lateral prostate. The changes in expression of a subset of 1990 genes (∼80%) were blocked upon cotreatment with ICI and bromocriptine, respectively, whereas those of 262 genes (∼10%) were blocked only by treatment with ICI, suggesting that E2-induced pituitary PRL is the primary mediator of the prostatic transcriptional response to the altered hormone milieu. Bioinformatics analyses identified hormone-responsive gene networks involved in immune responses, stromal tissue remodeling, and the ERK pathway. In particular, our data suggest that IL-1β may mediate, at least in part, hormone-induced changes in gene expression during PIN formation. Together, these data highlight the importance of pituitary PRL in estrogen-induced prostate tumorigenesis. The identification of both E2- and pituitary PRL-responsive genes provides a comprehensive resource for future investigations of the complex mechanisms by which changes in the endocrine milieu contribute to prostate carcinogenesis in vivo.
Hepatitis: The Virus and Its Characteristics, Clinical Manifestations, and Evaluation of Liver Damage
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of out of hours care provided by patients' own general practitioners and commercial deputising services: a randomised controlled trial. I: The process of care
Authors: D K Cragg, R K McKinley, M O Roland, S M Campbell, F Van, A M Hastings, D P French, T K Manku-Scott, C Roberts
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objectives:</b> To compare the process of out of hours care provided by general practitioners from patients9 own practices and by commercial deputising services. <b>Design:</b> Randomised controlled trial. <b>Setting:</b> Four urban areas in Manchester, Salford, Stockport, and Leicester. <b>Subjects:</b> 2152 patients who requested out of hours care, and 49 practice doctors and 183 deputising doctors (61% local principals) who responded to those requests. <b>Main outcome measures:</b> Response to call, time to visit, prescribing, and hospital admissions. <b>Results:</b> 1046 calls were dealt with by practice doctors and 1106 by deputising doctors. Practice doctors were more likely to give telephone advice (20.2% <i>v</i> 0.72% of calls) and to visit more quickly than deputising doctors (median delay 35 minutes <i>v</i> 52 minutes). Practice doctors were less likely than deputising doctors to issue a prescription (56.1% <i>v</i> 63.2% of patients) or to prescribe an antibiotic (43.7% <i>v</i> 61.3% of prescriptions issued) and more likely to prescribe generic drugs (58.4% <i>v</i> 32.1% of drugs prescribed), cheaper drugs (mean cost per prescription £3.28 <i>v</i> £5.04), and drugs in a predefined out of hours formulary (49.8% <i>v</i> 41.1% of drugs prescribed). There was no significant difference in the number of hospital admissions. <b>Conclusions:</b> By contrast with practice doctors, deputising doctors providing out of hours care less readily give telephone advice, take longer to visit at home, and have patterns of prescribing that may be less discriminating. <h3>Key messages</h3> In response to a request for out of hours care, practice doctors are more likely than deputising services to offer telephone advice When patients are visited at home, practice doctors can get there sooner Practice doctors give fewer, cheaper, and possibly more discriminating prescriptions In this series there was no difference in the number or duration of hospital admissions between the two groups of doctors
Molecular and cellular aspects of the insulin-like growth factor I receptor
Authors: D. LeRoith
Journal: Endocrine Reviews (1995)

THE insulin-like growth factors (IGFs) and their receptors and binding proteins constitute a family of cellular modulators that play essential roles in the regulation of growth and development. The IGF ligands include three structurally related peptides: insulin, IGF-I, and IGF-II. Unlike insulin, IGF-I and IGF-II are expressed ubiquitously, albeit in a highly regulated manner (see reviews in Refs. 1-5). The biological functions of the IGFs are mediated by a family of transmembrane receptors, which includes the insulin, IGF-I, and IGF-II/mannose-6-phosphate (M-6-P) receptors. While the IGF-I receptor is the primary mediator of IGF action, the insulin and IGF-II/M-6-P receptors may also mediate some of these functions (Fig. 1) (6, 7). The biological actions of the IGFs are modulated by a family of at least six IGF-binding proteins (IGFBPs) that are found in the circulation and in extracellular compartments and are produced by most tissues. The IGFBPs are capable of inhibiting or enhancing IGF effects and may even have ligand-independent effects (see reviews in Refs. 8–11). This review will focus on the IGF-I receptor and will discuss various aspects of its molecular structure and the cellular effects elicited by its activation.
Experience with a digital computer for study and improved management of the critically ill
Authors: M. H. Weil
Journal: JAMA (1966)

Automated techniques, now bolstered by the availability of a computer, have become increasingly important in recent years as medicine seeks to fulfill the need for ever more comprehensive and technically complex services. Detailed analysis of physiological data by manual methods is inefficient, both for clinical research and for practical use at the bedside. A combination of sensors, with analysis of their output by an on-line computer, offers a means of achieving a comprehensive inventory of patient condition for immediate use by the physician and the clinical investigator. Automated measurement and collection of biological data in a clinical setting has been used in a number of areas.<sup>1,2</sup>Automated analog devices have been developed for measuring blood pressure by the use of indirect auscultatory techniques.<sup>3-6</sup>These devices are not entirely satisfactory for patients in shock, however, since the indirectly obtained blood pressure loses accuracy under conditions of markedly reduced blood
Die Elektrokardiographie und andere graphische Methoden in der Kreislaufdiagnostik.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
Authors: Yuan Yuan, Young Seok Ju, Youngwook Kim, Jun Li, Yumeng Wang, Christopher J. Yoon, Yang Yang, Inigo Martincorena, Chad J. Creighton, John N. Weinstein, Yanxun Xu, Leng Han, Hyung-Lae Kim, Hidewaki Nakagawa, Keunchil Park, Peter J. Campbell, Han Liang
Journal: Nature Genetics (2020)
Abstract 1809: LncRNA-SOX2-OT contributes to head and neck cancer cell proliferation by regulating DDIT4
Authors: Ru Wang, Yifan Yang, Chen Tan, Ling Feng, Jugao Fang
Journal: Cancer Research (2019)

Abstract Background: Long non-coding RNAs (lncRNAs) have been shown to serve as an oncogenic role in human cancers. However, the role of lncRNAs in head and neck squamous cell carcinoma (HNSCC) is still unclear. Methods and Results: Our previous microarray analysis showed that lncRNA SOX2-OT was upregulated in HNSCC tumor tissues and was correlated with DDIT4. To determine whether SOX2-OT served as a poor prognosis factor and targeted DDIT4 to facilitate cell proliferation and tumorigenesis in human HNSCC, qRT-PCR tested the relative expression of SOX2-OT and DDIT4 in 60 pairs of LSCC cancer tissues and the corresponding adjacent non-cancer tissues. Cell functional assay was conducted in vitro. We validated the up-regulation of SOX2-OT and DDIT4 in HNSCC tissues. Furthermore, we found that high SOX2-OT expression was significantly associated with advanced tumor differentiation, and worse prognosis. In vitro experiments demonstrated that SOX2-OT functioned as an oncogene by promoting cell proliferation and inhibiting cell apoptosis, and SOX2-OT targeted DDIT4 as its competing endogenous RNA in HNSCC cells. Conclusions: Our findings for the first time identify the oncogenic role of SOX2-OT in HNSCC, demonstrating that SOX2-OT is a potential prognostic biomarker and promising therapeutic target in HNSCC. Note: This abstract was not presented at the meeting. Citation Format: Ru Wang, Yifan Yang, Chen Tan, Ling Feng, Jugao Fang. LncRNA-SOX2-OT contributes to head and neck cancer cell proliferation by regulating DDIT4 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1809.
Richard Mead (1673-1754) Successor to John Radcliffe
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent Findings on the Carcinogenicity of Chlorinated Olefins
Authors: Cesare Maltoni
Journal: Environmental Health Perspectives (1977)

Data are presented on factors affecting the carcinogenic effects of chlorinated olefins, such as molecular structure, concentration, length of treatment, route of administration and animal species, strain, sex, and age. The observations are based upon carcinogenicity experimental bioassays of vinyl chloride and vinylidene chloride. Early results, which appear to show that some of these factors (particularly species, strain, and sex) act by affecting the metabolism of the tested compounds, are presented, and the need for metabolic characterization of experimental animals in chemical carcinogenesis is stressed.