tbuckley/cabot-search huggingface dataset:
Chromium(III)-Induced 8-Hydroxydeoxyguanosine in DNA and Its Reduction by Antioxidants: Comparative Effects of Melatonin, Ascorbate, and Vitamin E
Authors: Wenbo Qi, Russel J. Reiter, Dun-Xian Tan, Joaquin J. Garcia, Lucien C. Manchester, Malgorzata Karbownik, Juan R. Calvo
Journal: Environmental Health Perspectives (2000)

Chromium compounds are well documented carcinogens. Cr(III) is more reactive than Cr(VI) toward DNA under in vitro conditions. In the present study, we investigated the ability of Cr(III) to induce oxidative DNA damage by examining the formation of 8-hydroxydeoxyguanosine (8-OH-dG) in calf thymus DNA incubated with CrCl(3) plus H(2)O(2). We measured 8-OH-dG using HPLC with electrochemical detection. In the presence of H(2)O(2), we observed that Cr(III)-induced formation of 8-OH-dG in isolated DNA was dose and time dependent. Melatonin, ascorbate, and vitamin E (Trolox), all of which are free radical scavengers, markedly inhibited the formation of 8-OH-dG in a concentration-dependent manner. The concentration that reduced DNA damage by 50% was 0.51, 30.4, and 36.2 microM for melatonin, ascorbate, and Trolox, respectively. The results show that melatonin is 60- and 70-fold more effective than ascorbate or vitamin E, respectively, in reducing oxidative DNA damage in this in vitro model. These findings also are consistent with the conclusion that the carcinogenic mechanism of Cr(III) is possibly due to Cr(III)-mediated Fenton-type reactions and that melatonin's highly protective effects against Cr(III) relate, at least in part, to its direct hydroxyl radical scavenging ability.
Erratum
Journal: JNCI Journal of the National Cancer Institute (1963)

In the announcement “Fourteen Strains of Cells Certified,” page 399, the first paragraph should read, “The Cell Culture Collection Committee, organized in 1960 to establish standards for animal cell strains used in biologic research, and whose repository is the American Type Culture Collection at 2112 M Street, NW, Washington 7, D.C., has certified 14 strains of cells.”
TOC 2nd page
Authors: Hugh Sampson, New York, Heimo Breiteneder, Christian Radauer, S Johansson, Thomas Bieber, Ronald Dahl, Peter Friedmann, Bobby Lanier, Richard Lockey, Cassim Motala, Jose Ortega Martell, Thomas Platts-Mills, Johannes Ring, Frank Thien, Paul Van Cauwenberge, Hywel Williams, F Estelle, R Simons
Journal: Journal of Allergy and Clinical Immunology (2004)
The resurgence of measles and herd immunity
Authors: B. P. Lanphear
Journal: JAMA (1992)

<h3>In Reply.</h3> —The term "officially censured" refers to a resolution adopted by the AMA House of Delegates in June 1990 and noted in Dr Barnard's letter. Contrary to Barnard's statement, this resolution was debated fully in a Reference Committee hearing at which Barnard was present and at which he was given several opportunities to present his views in full. The Reference Committee heard overwhelming support for passage of this resolution and consequently recommended that it be included on the consent calendar for approval by the AMA House of Delegates. This procedure is traditionally reserved for those resolutions that the Reference Committee believes have strong and obvious support. The House of Delegates had ample opportunity to remove this item of business from the consent calendar for specific discussion on the floor of the House of Delegates but chose instead to move for passage. The resolution was passed without dissenting vote and
Heroin
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1972)

EVERYONE agrees, or says so, that the problem of heroin addiction has become transformed in a decade from a nagging worry for a few authorities in a few cities into one of the most urgent, disastrously unsolved and, in a way, ominously symbolic of all our social problems. We have rarely had such a consensus on a social issue; everyone agrees that it is a great evil and that we ought to be doing something about it immediately, on a scale to match the immensity of the problem, spare no expense. Put a stop to it, somehow, anyhow.Still, it . . .
Benzene Caution
Authors: Joan Stephenson
Journal: JAMA (2005)

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ERGOGRAPHIC TESTS IN SCHOOL CHILDREN.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physics
Authors: John J. Keveney
Journal: Annals of Internal Medicine (1999)

Ad Libitum2 November 1999PhysicsJohn J. Keveney, MDJohn J. Keveney, MDTulsa, OK 74114 (Keveney)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-9-199911020-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It has come to that.Your life is a rumora whisper in a crowded rooman exclamation point in someone else's dayThe ending of a path.The white coats bunch in the corner,line the walls. Not like beforewhen there was some procedure to dosomething to save, words to say.They come and leave in a rushDid the old ones who could do nothingdo this better? Could they be with youat this passing time. See the light gofeel your presence slide awayenergy ... Author, Article, and Disclosure InformationAffiliations: Tulsa, OK 74114 (Keveney)Corresponding Author: John J. Keveney, MD, 611 West 15th Street, Apartment F2, Tulsa, OK 74127. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 November 1999Volume 131, Issue 9Page: 672 ePublished: 15 August 2000 Issue Published: 2 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cervico-Vaginitis of Gonococcal Origin in Children: Report of a Project of the Bellevue-Yorkville Health Demonstration of New York City.
Journal: JAMA (1933)

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Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization
Authors: Kana Miyamoto, Shigeyuki Yoshida, Miyuri Kawasumi, Kazuaki Hashimoto, Tokuhiro Kimura, Yuiko Sato, Tami Kobayashi, Yoshiteru Miyauchi, Hiroko Hoshi, Ryotaro Iwasaki, Hiroya Miyamoto, Wu Hao, Hideo Morioka, Kazuhiro Chiba, Takashi Kobayashi, Hisataka Yasuda, Josef M. Penninger, Yoshiaki Toyama, Toshio Suda, Takeshi Miyamoto
Journal: The Journal of Experimental Medicine (2011)
FATALITIES OF THE FOURTH.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Œdema and Nephritis. A Critical, Experimental and Clinical Study of the Physiology and Pathology of Water Absorption in the Living Organism.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sarcoidosis presenting with finger pain
Authors: D. J. Pierson
Journal: JAMA (1978)

THE CLINICAL onset of sarcoidosis is notoriously varied, with initial symptoms in any of several organ systems. Involvement of the skeleton is usually asymptomatic, however, and typically occurs in the course of established, generalized disease. We report the case of a patient with pain from an apparently isolated lytic bone lesion constituting the only presenting symptom. <h3>Report of a Case</h3> A 21-year-old man complained of pain and swelling of one month's duration at the tip of his right index finger. There was no history of trauma to the finger. Minimal swelling, redness, and palpation tenderness of the distal phalanx of the right index finger were the only physical findings. Roentgenographic examination of the hands demonstrated a 4-mm lytic lesion in the right index finger at the tip of the distal phalanx, with resorption of the terminal tuft (Fig 1). A chest roentgenogram showed prominent bilateral hilar adenopathy (Fig 2). Routine
Radiology
Authors: Harold G. Jacobson
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TEMPERANCE INSTRUCTION IN PUBLIC SCHOOLS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 132: Methylprednisolone Pulse Therapy for Kawasaki Disease with Symptomatic Myocarditis
Authors: yeo hyang kim, Chae Ok Shin, Myung Chul Hyun, Dong Seok Lee
Journal: Circulation (2015)

Purpose: Kawasaki disease (KD) is an acute febrile illness of infants and young children that is characterized by a systemic vasculitis, especially involving the coronary arteries. Although, sometimes, subclinical myocarditis is combined in KD, symptomatic myocarditis is extremely uncommon. We report a 7 year old boy who developed hypotension and decreased left ventricular systolic function (EF 40%) in the acute phase of KD. Case: A 7 year old boy (height 115 cm, body weight 20 kg) was admitted because of 2 days of persistent fever and left cervical lymphadenopathy (white blood cell count 17,870 /mm 3 , C reactive protein 23.6 mg/dL). Conjunctiva injection and lip redness developed on the 4th day of illness, and hypotension and tachycardia (SBP 59/DBP 29 mmHg, HR 153/bpm) were combined. The echocardiography revealed a decreased ejection fraction (EF) (40%) without chamber dilatation and normal coronary artery size (LM 1.9mm, z score=-1.3, RCA 2.3mm, z score=0.4). The level of N terminal pro BNP was 28,000 pg/mL. With a diagnosis of KD with myocarditis, he was initially treated with inotropics and intravenous immunoglobulin (2 g/kg). Without clinical improvement in spite of initial treatment, A change of coronary arterial size (LM 2.9mm, z score=1.2, RCA 3.1mm, z score=2.3) was developed and decreased LV systolic function (EF 45%) and fever were persisted. Then, he was given 3 daily pulses of intravenous methylprednisolone followed by tapering doses of oral prednisolone. He showed prompt clinical recovery after pulse therapy of intravenous methylprednisolone (SBP 95/DBP 49 mmHg, HR 98/bpm). Although EF was improved (59%), coronary arterial dilatation was progressed (LM 3.4mm, z score=2.4 RCA 5.5mm, z score=7.9). Conclusions: The present case serves to highlight the fact that methylprednisolone should be considered as the priority in children with KD who have symptomatic myocarditis during the acute stage.
William Forsyth Milroy (1855-1942): hereditary edema of the lower legs
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary thromboembolism. Diagnosis and treatment
Authors: A. A. Sasahara
Journal: JAMA (1983)

PULMONARY embolism (PE) is a common complication that usually afflicts patients who are hospitalized for other medical or surgical problems. Its continued prevalence seems to be the result of increasing numbers of older and sicker patients who are hospitalized and subjected to longer periods of bed rest and more complex operations. Although the true incidence of PE is not known, a reasonable estimate can be made from various studies that suggest that fatal PE occurs in about three to five patients per 1,000 inpatients in a general hospital population, including both hipsurgery patients and patients with malignant neoplasms undergoing surgical procedures, and nonfatal PE occurs in about 15 to 20 patients per 1,000 inpatients. The mortality of undiagnosed and therefore untreated PE is relatively high, ranging from about 18% to 35%,<sup>1</sup>whereas, once diagnosed and treated, a substantial reduction to about 8% occurs. This observation underscores the importance of
HOSPITALS APPROVED FOR TRAINING INTERNS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Mastoid Operation, Including its History, Anatomy, and Pathology.
Journal: JAMA (1892)

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Errata
Authors: J Wohlrab, B Kref, A Kuhn, A.-M Meuth, D Bein, S Amler, S Beissert, M Bo, R Brehler, J Ehrchen, S Grundmann, M Haust, V Ruland, M Schiller, P Schulz, S Sta ¨nder, C Sauerland, W Ko, T Luger, G Bonsmann
Journal: British Journal of Dermatology (2010)

limumab 5,7 and ustekinumab. 5,8Additionally, it is still not known if PRP, as such, with its characteristics of a chronic inflammatory disease, is loaded with an increased tumour risk, and it can appear as a paraneoplastic symptom. 9t can indeed only be speculated on the basis of this case study whether the use of ustekinumab in PRP will prove to be an effective option as the second-and third-line therapy.