tbuckley/cabot-search huggingface dataset:
Lung transplantation
Authors: J. C. Baldwin
Journal: JAMA (1988)

For many years, the possibility of isolated lung transplantation for patients with end-stage pulmonary disease has been contemplated, and for the past 25 years, the procedure has been attempted clinically on a somewhat sporadic basis by skilled and dedicated investigators, without notable success.<sup>1</sup>Progress in this area has been limited principally by problems with healing of the bronchial anastomosis; by inadequacy of lung-graft preservation and the resultant "reimplantation" phenomenon; and, to a lesser extent, by the unavailability of optimal immunosuppressive agents. The remarkable success that has been achieved in heart transplantation resulted from a clinical amalgamation of technical expertise in cardiovascular surgery and the use of cardiopulmonary bypass; laboratory experience with hypothermic metabolic inhibition for graft preservation; experience with cytotoxic and immunosuppressive therapy in oncological and renal transplant work; and the establishment, through prospective clinical investigation, of valid criteria for the selection of recipients.<sup>2</sup>The establishment of combined
Infectious Diseases
Authors: Mark Y. Stoeckle
Journal: JAMA (1993)

The resurgence of tuberculosis (TB) in the United States and the spread of multidrug-resistant strains of TB (MDR-TB) are serious public health threats. As recently as 1989 it seemed possible to plan for the elimination of TB from the United States.<sup>1</sup>Decades of successful control efforts had resulted in a steady decline in the incidence of TB, from more than 84000 cases in 1953 to 22000 in 1984. However, this favorable trend ended in 1985: from 1985 to 1991, there were 39000 more cases than expected, and the annual case rate is increasing. In response to the current epidemic, major efforts in TB infection control and patient care have been initiated. The human immunodeficiency virus (HIV) epidemic seems to be a significant factor in the recent increase in TB cases. The risk of active TB among persons with HIV is exceedingly high. For those with latent tuberculous infection, 7%
William Carlos Williams: poet-physician of Rutherford
Authors: L. W. Wagner
Journal: JAMA (1968)

"How do you find the time, Doc?" people were always asking the genial New Jersey physician, as he published book after book in the midst of his busy medical career. "It's not finding time, it's<i>using</i>it," Williams would reply gruffly. "Two parts of a whole," he called medicine and poetry. And he wrote in his<i>Autobiography</i>, As a writer I have never felt that medicine interfered with me but rather that it was my very food and drink, the very thing that made it possible for me to write. Was I not interested in men? There the thing was, right in front of me. Modest as Williams was about his two occupations, his energy gives most of us pause. In this era of hypertension, a person like William Carlos Williams is a rarity. He survived the pressures of not one job, but two. Strong in his ambition to create,
Slit-Lamp Microscopy of the Living Eye. Early Diagnosis and Symptomatology of Affections of the Anterior Segment of the Eye.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Feedback reduces test use in a health maintenance organization
Authors: D. M. Berwick
Journal: JAMA (1986)

In a cross-over design, three interventions were tested for their impact on the rate of use of 12 commonly ordered blood tests and roentgenograms among internists in a health maintenance organization. Overall use fell by 14.2% in a 16-week period during which physicians received confidential feedback on their individual rates of use compared with peers (cost feedback). Eleven of 12 tests showed some decrease. Similar feedback on rates of abnormal test results (yield feedback) and a program of test-specific education failed to show a consistent effect. Variability in rates of test use among physicians, as measured by the coefficient of variation, fell by 8.3% with cost feedback, by 1.3% with yield feedback, and by 2.3% with education, but these changes were inconsistent across tests. (<i>JAMA</i>1986;255:1450-1454)
A multidisciplinary approach to non-alcoholic fatty liver disease (NAFLD) improves cardiovascular risk factors
Authors: Anna Mantovani, Atul Goyale, Davide Roccarina, Laura Iogna Prat, Marta Guerrero, Roshni Patel, Jennifer Clancy, Devaki Nair, Emmanuel Tsochatzis
Journal: Journal of Hepatology (2020)
The Examination of School Children’s Eyes and Ears
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LOCAL ANESTHESIA BY QUININ SALTS, AND THE COMMITTEE REPORT
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A FEW PARAGRAPHS ABOUT TOBACCO AMBLYOPIA.
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's new this month in BMJ Journals
Authors: Harvey Marcovitch
Journal: BMJ (2006)

A cross sectional survey of more than 8000 Australian men aged 16-59 has found that almost 10% had experienced erectile dysfunction for at least one month over the previous year. After adjustment for confounders such as age, marital status, and use of drugs for cardiovascular disease or diabetes, smoking remained a significant association. Intake of = 20 cigarettes per day led to an odds ratio of 1.36 (95% CI 1.05 to 1.83); intake < 20 per day had an odds ratio of 1.24 (1.01 to 1.52). The good news is that modest alcohol intake had an inverse relation. The authors say that this finding could be used to increase motivation for young men to quit smoking. Tobacco Control2006;15: 1466–9 [OpenUrl][1][Abstract/FREE Full Text][2] Paediatricians in Bolton reviewed 380 children referred to a clinic dedicated to “fits, faints and funny turns.” Epilepsy was confirmed in just 89; … [1]: {openurl}?query=rft.jtitle%253DTobacco%2BControl%26rft.stitle%253DTobacco%2BControl%26rft.issn%253D0964-4563%26rft.aulast%253DMillett%26rft.auinit1%253DC%26rft.volume%253D15%26rft.issue%253D2%26rft.spage%253D136%26rft.epage%253D139%26rft.atitle%253DSmoking%2Band%2Berectile%2Bdysfunction%253A%2Bfindings%2Bfrom%2Ba%2Brepresentative%2Bsample%2Bof%2BAustralian%2Bmen.%26rft_id%253Dinfo%253Adoi%252F10.1136%252Ftc.2005.015545%26rft_id%253Dinfo%253Apmid%252F16565463%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=tobaccocontrol&resid=15/2/136&atom=%2Fbmj%2F332%2F7550%2F1145.atom
Ultrasonography and parathyroid adenoma
Authors: J. J. Karo
Journal: JAMA (1978)

WE REPORT the cases of three patients in whom hyperparathyroidism was strongly suspected on clinical grounds and in whom ultrasonography of the neck showed the presence of a small mass near one of the lobes of the thyroid gland, which was believed to represent a parathyroid adenoma. All three patients underwent surgery, and the diagnosis and exact location of the adenoma was confirmed. <h3>Methods</h3> The ultrasound procedures were performed with a commercially available gray-scale ultrasound unit using a 5-MHz, 6-mm diameter, nonfocused transducer. The patients were examined in the supine position, with the neck hyperextended. Multiple transverse B scans were obtained from the level of the sternal notch superiorly in 0.5-cm intervals until thyroid tissue was no longer displayed (usually at the level of the larynx). Several longitudinal scans of each side of the neck were then obtained in 0.5-cm intervals. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 39-year-old man had
Efficacy of divalproex vs lithium and placebo in the treatment of mania. The Depakote Mania Study Group
Authors: C. L. Bowden
Journal: JAMA (1994)

<h3>Objective.</h3> —To compare the effectiveness of divalproex sodium with that of lithium and placebo in patients with acute mania. <h3>Design.</h3> —Randomized, double-blind, parallel-group study of treatment outcomes in patients with manic-depressive illness. <h3>Patients.</h3> —A total of 179 hospitalized, acutely manic patients meeting the Research Diagnostic Criteria for manic disorder, approximately half of whom had been nonresponsive to lithium previously, were studied at nine university-affiliated hospitals. <h3>Interventions.</h3> —After a minimum 3-day washout period, random assignment for 21 days to divalproex, lithium, or placebo in a 2:1:2 ratio. Dosage of divalproex and lithium was increased if tolerated to a target concentration of 1041 μmol/L (150 μg/ mL) or 1.5 mmol/L (conventionally expressed as milliequivalents per liter), respectively. <h3>Main Outcome Measures.</h3> —Primary outcome measures were changes in the Mania Rating scale derived from the Schedule for Affective Disorders and Schizophrenia. <h3>Results.</h3> —Intent-to-treat analysis for efficacy was based on data from 68, 35, and 73 patients in the divalproex, lithium, and placebo groups, respectively. Groups were initially comparable except that all eight patients with four or more manic episodes in the previous year were in the divalproex group. In 30%, 33%, and 51% of the above groups, treatment was prematurely terminated due to lack of efficacy, with fewer premature terminations from divalproex than placebo (<i>P</i>=.017). The proportions of patients improving at least 50% were higher for divalproex and lithium groups than for the placebo group: 48% for divalproex (<i>P</i>=.004) and 49% for lithium (<i>P</i>=.025) vs 25% for placebo. Divalproex was as effective in rapid-cycling manic patients as in other patients. <h3>Conclusions.</h3> —Both divalproex and lithium were significantly more effective than placebo in reducing the symptoms of acute mania. The efficacy of divalproex appears to be independent of prior responsiveness to lithium. (<i>JAMA</i>. 1994;271:918-924)
P0974 : Effects of resveratrol on experimental non-alcoholic steatohepatitis
Authors: S. Heebøll, K.L. Thomsen, A. Clouston, N. Jessen, E.I. Sundelin, S.B. Pedersen, Y. Radko, L.P. Christensen, L. Hebbard, H. Grønbæk, J. George
Journal: Journal of Hepatology (2015)
Chapin on Insanity.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SENSORY-INDUCED EPILEPSY
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone Mass After Treatment for Acute Lymphoblastic Leukemia in Childhood
Authors: Karsten Nysom, Kirsten Holm, Henrik Hertz, Jørn Müller, Kim Fleischer Michaelsen, Christian Mølgaard
Journal: Journal of Clinical Oncology (2001)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.11.2970 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11387373 Bone Mass After Treatment for Acute Lymphoblastic Leukemia in Childhood Karsten NysomxKarsten NysomSearch for articles by this author , Kirsten HolmxKirsten HolmSearch for articles by this author , Henrik HertzxHenrik HertzSearch for articles by this author , Jørn MüllerxJørn MüllerSearch for articles by this author , Kim Fleischer MichaelsenxKim Fleischer MichaelsenSearch for articles by this author , Christian MølgaardxChristian MølgaardSearch for articles by this author Show More The Juliane Marie Centre, Rigshospitalet, Copenhagen, DenmarkThe Royal Veterinary and Agricultural University, Frederiksberg, Denmark https://doi.org/10.1200/JCO.2001.19.11.2970 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
"Operated."
Authors: Casey A. Wood.
Journal: JAMA (1907)

Chicago, Jan. 14, 1907. <h3>To the Editor:</h3> —In an editorial inThe Journal, Jan. 12, 1907, you draw attention to the improper employment of the verb "to operate," without, however, referring to an article published inThe Journalsome twelve years ago (March 9, 1895, page 352) on "The Improper Use in Medical Literature of Certain Words and Phrases." In that essay you will find the objectionable use of "operate" discussed at length—as well as several other improprieties of the kind. Members of a learned profession like ours can hardly afford, even in a careless moment, to encourage the use of expressions that are notoriously incorrect and for which there is no lingual demand.
Abstract 1172: Neointima Formation is Dependent on p38α Mitogen-Activated Protein Kinase
Authors: Brandon M Proctor, Anthony J Muslin
Journal: Circulation (2007)

Neointima formation frequently occurs after arterial injury and is responsible for substantial human morbidity. We previously demonstrated that the intracellular linker protein Grb2 is required for neointima formation, and that Grb2 regulates p38α mitogen-activated protein kinase (MAPK) activation in vascular smooth muscle cells (SMCs). In this work, the role of p38α MAPK in neointima formation was examined. In vitro experiments showed that pharmacological inhibition of p38 MAPK activity in cultured SMCs blocked platelet-derived growth factor (PDGF)-stimulated DNA replication and cell proliferation. Specifically, in control SMCs, overnight stimulation with PDGF induced an 11.8-fold increase in thymidine incorporation and a 1.9 fold increase in cell number. However, inhibition of p38 MAPK activity reduced PDGF-induced thymidine incorporation to 2.8-fold (P = 0.0006) and completely blocked PDGF-stimulated cell proliferation (P = 0.0001). Also, p38 MAPK activity was required for PDGF-induced inactivation of the retinoblastoma tumor suppressor protein, Rb, and induction of mini-chromosome maintenance protein-6 (MCM6), a fundamental regulator of DNA replication. Next, compound transgenic mice were generated with doxycycline (Dox)-inducible, SMC-specific expression of a dominant-negative form of p38α MAPK (SMC-DN-p38α ). Dox induced robust expression of DN-p38α mRNA and protein in the aorta and carotid arteries of compound transgenic mice, and inactivation of native, arterial p38 MAPK. SMC-DN-p38α and single transgenic, control mice were subjected to carotid injury by use of an epoxy resin-beaded probe. After 21 days, control mice developed robust neointima formation that frequently resulted in an occlusive lesion with a mean neointima/media ratio of 2.62 (N = 8). In contrast, SMC-DN-p38α mice were resistant to the development of neointima. Specifically, neointima/media ratio was reduced to 0.63 for SMC-DN-p38α mice (N = 12; P = 0.045). In addition, compared to control mice, injured carotid arteries of SMC-DN-p38α mice showed defective p38 MAPK activation in SMCs of the tunica media. Our results demonstrate that vascular SMC p38α MAPK is required for neointima formation after arterial injury.
Letter: Fatal insect stings.
Authors: P Wilson
Journal: BMJ (1974)

recommnended by the Halsbury Committee would inflate these mind-boggling sums to 12p and 9p respectively.This, surely is the form in which doctors and the public at large should have N.H.S. expenditure presented to them.It would then be plain to all that for the medical profession to help the D.H.S.S. to wallow a little less deeply in the financial mire in which it now flounders is not only super- erogatery but iirrelevant.More important, this way of looking at the costs of the care of acute illness also offers a way of meeting those costs.If every patient in hospital, except perhaps the very young and the very old, contributed lOp a day to that hospital he could rest secure in the knowledge that this trivial premium-the cost of five cigarettes, a can of coke, a bar of chocolate, or 1pints of petrol-would ensure that whatever illness he had, whatever urgent service he might need, whatever unforseen comnplication or reverse he might suffer, cover would be provided at any houir of the day or night.Doubling the levy to a mere 2Op a day would, moreover, underwrite the de.spe,rately needed increase of salaries for nurses and ancillaries.Politicians of all colours have long lacked the courage to tell their electors that this kind of service must be paid for.Perhaps, after all, the D.H.S.S.