tbuckley/cabot-search huggingface dataset:
Abstract 1702: Blockade of B <sub>1</sub> in Kinin B <sub>2</sub> Receptor knockout mice Deteriorates Cardiac Function and Remodeling post-Myocardial Infarction
Authors: Jiang Xu, Oscar A Carretero, Edward G Shesely, Nour-Eddine Rhaleb, Xiao-Ping Yang
Journal: Circulation (2007)

We previously showed that the therapeutic effects of ACEi were diminished in B 2 knockout mice (B 2 −/−). However, lack of B 2 per se did not affect cardiac remodeling and dysfunction post myocardial infarction (MI), which may be partially due to upregulation of B 1 that may play a compensatory role for lack of the B 2. Here we hypothesize that blockade of B 1 in B 2 −/− mice accelerates and deteriorates cardiac remodeling and dysfunction post-MI. Male B 2 −/− and wild-type controls (C57BL/6J, B 2 +/+) were subjected to sham MI or MI (by ligating the left anterior descending coronary artery) and treated with either vehicle or B 1 antagonist (B 1 -ant, Ac-Lys[(αMe)phe 5 ,D-βNal 7 ,Ile 8 ]desArg 9 BK; 300 μg/kg/day via osmotic minipump, i.p.) for 8 weeks. Systolic blood pressure (SBP) was measured weekly by tail cuff, and LV diastolic chamber dimension (LVDd), mass and ejection fraction (EF) were evaluated by echocardiography. We found that SBP, cardiac morphology and function did not differ between strains in sham-MI mice. MI caused a similar increase in LV chamber dilatation and mass and decrease in EF between B 2 +/+ and B 2 −/− (Table ). However, in the presence of B 1 -ant, cardiac remodeling and dysfunction post-MI became more severe in B 2 −/− mice compared to B 2 +/+. SBP and infarct size were similar in all groups. These results suggest that the B 1 receptor may play an important role in preventing deterioration of cardiac function and remodeling post-MI when B 2 receptors are absent.
Familial Glucocorticoid Resistance Caused by a Novel Frameshift Glucocorticoid Receptor Mutation
Authors: P. Trebble, L. Matthews, J. Blaikley, A. W. O. Wayte, G. C. M. Black, A. Wilton, D. W. Ray
Journal: Endocrine Reviews (2010)

ABSTRACT Context Familial glucocorticoid resistance is a rare condition with a typical presentation of women with hirsutism and hypertension, with or without hypokalemia. Objective The aim was to determine the cause of apparent glucocorticoid resistance in a young woman. Patients and Methods We studied a family with a novel glucocorticoid receptor (GR) mutation and a surprisingly mild phenotype. Their discovery resulted from serendipitous measurement of serum cortisol with little biochemical or clinical evidence for either hyperandrogenism or mineralocorticoid excess. Results The causative mutation was identified as a frameshift mutation in exon 6. Transformed peripheral blood lymphocytes were generated to analyze GR expression in vitro. Carriers of the mutation had less full-length GR, but the predicted mutant GR protein was not detected. However, this does not exclude expression in vivo, and so the mutant GR (D612GR) was expressed in vitro. Simple reporter gene assays suggested that Δ612GR has dominant negative activity. Δ612GR was not subject to ligand-dependent Ser211 phosphorylation or to ligand-dependent degradation. A fluorophore-tagged construct showed that Δ612GR did not translocate to the nucleus in response to ligand and retarded translocation of the wild-type GR. These data suggest that Δ612GR is not capable of binding ligand and exerts dominant negative activity through heterodimerization with wild-type GR. Conclusion Therefore, we describe a novel, naturally occurring GR mutation that results in familial glucocorticoid resistance. The mutant GR protein, if expressed in vivo, is predicted to exert dominant negative activity by impairing wild-type GR nuclear translocation.
Die Ursachen der Entstehung des Kropfes (Struma) und seiner Formen bei Mensch und Tier mit Ausblicken auf rationelle Prophylaxe und Heilung. Deduktive und synthetisch-experimentelle Studien über die Variationen des thyreothymischen Systemes der Vertebraten und des Menschen unter dem Einfluss der Umwelt
Journal: JAMA (1942)
Transplantation
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of zoster immune plasma. Treatment of cutaneous disseminated zoster in immunocompromised patients
Authors: K. E. Groth
Journal: JAMA (1978)

Zoster immune plasma (ZIP) was evaluated for treatment of cutaneous disseminated zoster in immunocompromised hosts. Twenty patients were studied: 13 were enrolled in a double-blind protocol, five received ZIP under an open protocol, and two were observed without receiving a transfusion. In the double-blind study, eight patients actually received ZIP; five were given plasma lacking varicella-zoster virus antibodies (control plasma). The clinical course of zoster in the group given ZIP was the same as that of patients given control plasma or no transfusions. Because ZIP did not alter the clinical course of zoster and because zoster patients produced high-antibody titers without ZIP, we concluded that ZIP is not useful for treatment of cutaneous disseminated zoster and should be reserved for prevention or modification of varicella in exposed, susceptible immunocompromised patients. (<i>JAMA</i>239:1877-1879, 1978)
Extensive hypertensive work-up. In rebuttal to Dr. Finnerty
Authors: J. C. Melby
Journal: JAMA (1975)

IT IS of considerable interest that Finnerty and I reached our differing conclusions regarding the extent of work-up necessary for the hypertensive patient from essentially the same data. The differing conclusions, I believe, result in large part from an epidemiologic- or public health-oriented approach to patient care, on the one hand, and a more traditional concept of the physician-patient relationship on the other. There is logic in the therapeutic approach advocated by Finnerty, and it is possible that curable secondary hypertension might be recognized during long-term therapy. Furthermore, it is possible to recognize volume-dependent hypertension on the basis of response to diuretic therapy alone. If one accepts (as do Finnerty and Gifford) that curable secondary hypertension accounts for 6% of the hypertensive population, this still amounts to an incidence of more than 1.3 million patients with remediable disease. If one adds to this population those patients with imbalances of the
Commentary
Authors: G A Davis
Journal: British Journal of Sports Medicine (2001)

Rupture of the circumflex artery and nerve, without fracture or dislocation, is a rare traumatic event.Such a case is reported in a champion flat jockey who sustained blunt trauma to the shoulder after a fall during a race; the literature is also reviewed.At urgent surgical exploration, the axillary artery and nerve were repaired.The patient subsequently successfully returned to professional riding.This case highlights the diYculties in diagnosis and management.
Radioisotope localization of the placenta in polaroid color
Authors: L. Krohn
Journal: JAMA (1967)

A safe and accurate method of localization of the placenta is still of prime importance in establishing a positive diagnosis of placenta previa. However, with the increasing use of amniocentesis<sup>1</sup>for analysis of amniotic fluid and fetal transfusion in the management of erythroblastosis fetalis, for amniography, and for the diagnosis of fetal death and induction of labor in such cases by the instillation of hypertonic solutions, more specific knowledge of the exact location of the placenta becomes essential to eliminate the risk of trauma to the placenta when inserting the needle into the amniotic sac. The use of radioactive isotopes for placental localization is generally accepted as superior to other techniques.<sup>2</sup>Soft tissue x-ray techniques with or without contrast media<sup>3,4</sup>have enjoyed a limited degree of success, being of little diagnostic value before the 35th week of gestation. Aortography<sup>5</sup>and retrograde femoral arteriography<sup>6</sup>are more
Physiology of the New Human Organs Discovered by Zuckerkandl.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MOVEMENT OF THE BILE
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combination Anti-CD74 (Milatuzumab) and CD20 (Rituximab) Monoclonal Antibody Therapy Has in Vitro and in Vivo Activity in Mantle Cell Lymphoma
Authors: Lapo Alinari, Erin Hertlein, David M. Goldenberg, Rosa Lapalombella, Fengting Yan, Xiaoli Zhang, David M. Lucas, Natarajan Muthusamy, John C. Byrd, Robert A. Baiocchi
Journal: Blood (2008)
Digoxin intoxication and hyperkalemia
Authors: G. W. Josephson
Journal: JAMA (1980)

<h3>To the Editor.—</h3> The recent article discussing digoxin intoxication by Warren and Fanestil (242:2100, 1979), "Digoxin Overdose: Limitations of Hemoperfusion-Hemodialysis Treatment," raises many questions. While I am sure that the authors would now agree that their failure to influence serum digoxin levels and clinical outcome substantially by charcoal hemoperfusion was predictable in light of digoxin's high volume of distribution, the use of hemodialysis for reduction of serum potassium levels can also be questioned. It is generally accepted that hyperkalemia secondary to digoxin intoxication results from poisoning of the adenosine triphosphatase (ATPase)dependent sodium potassium membrane transport system.<sup>1,2</sup>This has the effect of raising extracellular potassium levels at the expense of intracellular stores (ie, depletion) and results in a reduced resting membrane potential with decreased automaticity. Hence, potassium infusion, even in the absence of arrhythmias or hypokalemia, is an accepted treatment for digoxin intoxication, particularly when "digoxin-toxic" dysrhythmias are observed.<sup>3</sup>
The prevalence <i>RAS</i> and <i>BRAF</i> mutations among patients in the Middle East and Northern Africa with metastatic colorectal cancer.
Authors: Tamer Garawin, Kimberly Lowe, George Kafatos, Samuel Murray
Journal: Journal of Clinical Oncology (2016)

e15077 Background: Anti-EGFR therapies are recommended for metastatic colorectal cancer (mCRC) patients with confirmed wild-type RAS (exons 2, 3, 4 of KRAS and NRAS) status. There is limited published information on the prevalence of RAS mutations using real world data. The objective of this study was estimate the prevalence of RAS and BRAF mutations among patients with mCRC in the Middle East and Northern Africa (MENA) in an effort to inform the rationale for biomarker testing and treatment choice. Methods: The study included 1,669 patients from August 2013 to July 2015 with mCRC from Algeria, Bahrain, Egypt, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Qatar, Saudi Arabia, and the United Arab Emeritus. Information on RAS mutation status was obtained from one pathology lab using High Resolution Melting Analysis. Extended RAS analysis was conducted in a subset of patients, including: overall RAS (exon 2, 3, 4 of KRAS and NRAS; n = 750), KRAS exon 2 (n = 750), KRAS exon 3 and 4 (n = 507), NRAS exon 2, 3, and 4 (n = 507), and BRAF exon 15 (n = 78). The proportion of patients with each mutation was summarized. Results: The overall RAS mutation in the full sample was 35.3% (n = 589/1669). The observed mutation for KRAS exon 2 in a subset of patients with extended RAS analysis (n = 750) was 32.4% (243/750). Out of the subjects with wild-type exon 2 (n = 507), the observed mutations rates were as follows: KRAS exon 4 (20/507 = 3.9%), KRAS exon 3 (13/507 = 2.6%), NRAS exon 2 (7/507 = 1.4%), NRAS exon 3 (6/507 = 1.2%), and NRAS exon 4 (0%). The prevalence of BRAF exon 15 was 3.8% (3/78). The most robust data on specific RAS mutations was obtained from Algeria, Egypt, and Saudi Arabia. The prevalence of KRAS exon 2 mutations in these countries was as follows: Algeria (n = 33/86 = 38.4%), Egypt (n = 83/303 = 27.4%), Saudi Arabia (n = 85/245 = 34.7%). Conclusions: To our knowledge, this is the first study to evaluate the prevalence of RAS and BRAF mutations in the Middle East using real world data. The results of this descriptive study illustrate that there is variation in the prevalence of RAS and BRAF mutations in MENA.
Implantable Pacemakers Seem Effective In Reducing Blood Pressure Levels
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Masters of Medicine. Claude Bernard.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How reliable are tumor measurements?
Authors: J. Gurland
Journal: JAMA (1965)

Discrepancy between measurements of tumors made independently by different physicians can be substantial. There are also differences between measurements of tumors made by the same physician on different occasions, but some physicians are significantly more consistent than others. The techniques by which measurements are made, namely, readings and tracings in the case of lesions shown on x-ray film, affect this relative consistency—some physicians may be relatively consistent by one technique but relatively inconsistent by another. Probability considerations concerning the wrong decisions that can be made regarding change of size indicate that descriptions of changes in small lesions are very unreliable.
ALLERGIC MIGRAINE
Authors: WARREN T. VAUGHAN
Journal: JAMA (1927)

The suggestion that migraine is sometimes a phenomenon of protein sensitization is not new. The concurrence of this disease with asthma, urticaria and hay-fever either in one individual or in one family was first mentioned long ago. Many contributions have presented indirect evidence tending to substantiate this hypothesis, but I have not discovered any description of cases or of experimental work in which the cause was discovered, the disease relieved by the removal thereof and caused to return, following the reapplication of the etiologic factor. In allergy this roughly parallels Koch's postulates as applied to bacteriology, and is a necessary antecedent to acceptance of the theory. As early as the first half of the ninteenth century migraine was grouped by some, particularly members of the French school, such as Trousseau, Bouchard and Dieulafoy, with asthma, eczema, epilepsy, gout and lithiasis, and these conditions together constituted the manifestations of the lithemic
Vitamin B<sub>12</sub>and Pernicious Anemia
Authors: Maurice B. Strauss
Journal: New England Journal of Medicine (1950)

Vitamin B12 and Growth Factors for Rats Just as the hen's diet affects the chick's requirement for growth factors, so the diet fed to impregnated rats influences the growth factors needed by the litters. When weanling rats of depleted dams are fed casein extracted with hot alcohol they fail to grow.79 The growth factor is found in commercial casein, in variable amounts in "vitamin-free" casein, and in large amounts in commercial liver extracts. Milk, skimmed milk, cheese, beef and pork muscle contain this factor. Egg yolk contains variable amounts of the factor, depending on the hens' diet.80 Although the . . .
Disinfectant Agent
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHOOSING OUR IMMIGRANTS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal