tbuckley/cabot-search huggingface dataset:
Reductions in Regional Myocardial Function at Rest in Conscious Dogs With Chronically Reduced Regional Coronary Artery Pressure
Authors: John M. Canty, Francis J. Klocke
Journal: Circulation Research (1987)

We have examined the temporal response of regional subendocardial function in conscious chronically instrumented dogs following implantation of a circumflex ameroid occluder.Col lateral izat ion was limited by ligation of epicardial anastamoses between the circumflex and adjacent coronary arteries at the time of instrumentation.Sonomicrometrically measured regional function in the circumflex coronary artery became depressed relative to that in the left anterior descending coronary artery bed under resting conditions with the onset of an aortic-circumflex pressure gradient of 15 ±2.9 mm Hg (mean ± SEM).At the time of total ameroid occlusion, the ratio of circumflex to left anterior descending coronary artery function fell to 68 ±8% of control, with mean circumflex coronary pressure decreasing to 60± 1.6 mm Hg.Following ameroid occlusion, distal coronary pressure increased, and circumflex function recovered towards control but remained depressed relative to that in the left anterior descending coronary artery for 2-4 weeks.Measurements of regional subendocardial perfusion suggested a dissociation between subendocardial flow and function prior to but not following coronary occlusion by the ameroid.We conclude that this model results in reductions in regional function that are relatively prolonged and are not readily attributable to subendocardial infarction or a critical reduction in resting coronary flow.The data suggest that functional adaptations in response to gradually developing coronary occlusion are more complex than those associated with acute reductions in coronary artery pressure and flow.{Circulation Research 1987;61(suppl II):II-107-II-116) R egional myocardial mechanical function is closely coupled to coronary blood flow during _ acute reductions in coronary pressure produced by coronary artery constriction. 1" 5 When intrinsic autoregulatory mechanisms fail to maintain coronary flow at a constant level, subendocardial perfusion falls, and subendocardial function measured by segment shortening or wall thickening becomes depressed.These reductions in function are generally reversible as long as coronary flow is restored to normal levels before myocardial necrosis develops.Measurements of regional myocardial performance and perfusion in patients with coronary artery disease suggest that the response to a chronic reduction in regional coronary artery pressure is more complex than that observed acutely in animal models of transient
Diagnostic imaging in pediatric renal inflammatory disease
Authors: J. R. Sty
Journal: JAMA (1986)

THE TERM "<i>renal inflammatory disease</i>" encompasses a broad spectrum of conditions in pediatrics. These include diffuse pyelonephritis, focal pyelonephritis, renal abscess, pyonephrosis, and pararenal retroperitoneal abscesses due to infection of the urinary tract. Uncomplicated pyelonephritis does not require imaging for diagnosis if the clinical presentation and laboratory data are characteristic. However, the signs and symptoms of infection of the upper urinary tract in children may present a diagnostic challenge. During the neonatal period, infections of the urinary tract are more common among boys and nonspecific symptoms predominate. These include poor feeding, slow gain in weight, vomiting, diarrhea, irritability, and jaundice. Fever or hypothermia also is often present. Bacteremia occurs in approximately 35% of newborns with infection of the urinary tract.<sup>1</sup>In infants aged 1 month to 2 years, nonspecific manifestations still predominate, but sepsis and severe illness are less frequent than in the neonate. Among ambulatory children younger than
The Memphis chronic disease program. Comparisons in outcome and the nurse's extended role
Authors: J. W. Runyan
Journal: JAMA (1975)

IN PREVIOUS communications, the service program in Memphis and Shelby County (Tennessee) for the continuing care of patients with selected chronic diseases has been described.<sup>1-5</sup> Since the report in 1970,<sup>2</sup>more than 140,000 patient-visits to the decentralized facilities have been made, and patients under regular care now exceed 9,000. The number of urban and rural neighborhood and satellite clinics, which are operated by the Health Department, has been increased to 20, with several more planned. Although the main efforts have been service oriented and directed toward meeting the medical needs of a large chronically diseased population, some measurements of the effectiveness and acceptability of continuing care to patients in the program and its effects on the course of the chronic illness have been presented recently.<sup>5</sup>This report extends these observations but is primarily concerned with making certain comparisons between patients receiving care in decentralized facilities staffed by
Treatment Attempts of Proved Rabies in Man
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Constipated Lymphocytes"
Authors: GLENN TISMAN
Journal: Annals of Internal Medicine (1973)

Letters1 March 1973"Constipated Lymphocytes"GLENN TISMAN, M.D.GLENN TISMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-3-453 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Nardo and Norton (1) of a case of chronic lymphocytosis with lymphocytic inclusions (apparently a newly recognized form of lymphocytic leukemia) suggests possible import of a similar case presently being studied by us.The patient, a 48-year-old white woman, was anxious about a lymphocytosis that had persisted for "many years." She also complained of weakness; physical examination was unremarkable. In the peripheral blood smear stained with Wright's and Giemsa stains approximately 80% of the white blood cells were lymphocytes, and 60% of the lymphocytes contained large, clear, cytoplasmic vacuoles (Figure 1A and B). The...References1. NARDONORTON JW: Chronic lymphocytosis with lymphocytic inclusions. Ann Intern Med 76:265-268, 1972 LinkGoogle Scholar2. PERNISFORNIAMANTE BLL: Immunoglobulin spots on the surface of rabbit lymphocytes. J Exp Med 132:1001-1018, 1972 CrossrefGoogle Scholar3. TISMANENGLEBERGBATEMAN GMJ: Lymphocyte immunology (Ig) receptors and mitogen responsiveness: aids in determining early stage lymphoproliferative disease and therapy (abstract). Clin Res 20:744, 1972 Google Scholar4. SAGONEHURTUBISEMURPHY APS: Chronic lymphocytic leukemia (CLL) lymphocyte: B or T cell (abstract). Blood 40:960, 1972 Google Scholar5. CHOIBIGGARGOOD YWR: Biosynthesis and secretion of immunoglobulins by peripheral blood lymphocytes in severe hypogammaglobulinaemia. Lancet 1:1149-1151, 1972 CrossrefMedlineGoogle Scholar6. RIVERTEWKSBURYFEDENBERG GDH: "Nonsecretory" multiple myeloma. Blood 40:204-206, 1972 CrossrefMedlineGoogle Scholar7. AISENBERGBLOCK AK: Immunoglobulins on the surface of neoplastic lymphocytes. J Exp Med 287:272-276, 1972 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: LAC/USC School of Medicine Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1973Volume 78, Issue 3Page: 453-454KeywordsLymphocytesLymphocytic leukemiaWhite blood cells Issue Published: 1 March 1973 PDF DownloadLoading ...
Impotence in diabetic and non-diabetic hospital outpatients
Authors: E. Lester, F J Woodroffe
Journal: BMJ (1980)

One explanation of these anomalies is that talc may be acting as a particulate adjuvant, promoting cell-mediated hypersensitivity reactions to polysaccharide antigens of starch in susceptible individuals.For these reasons we would support efforts to eliminate talc, which although not directly pathogenic in low con- centration, may facilitate cell-mediated re- action to other agents on the surface of surgical gloves.
Randomization Procedures
Authors: STEPHEN J. W. EVANS
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 August 1983Randomization ProceduresSTEPHEN J. W. EVANS, M.SC., THOMAS D. WALSH, M.SC.STEPHEN J. W. EVANS, M.SC.Search for more papers by this author, THOMAS D. WALSH, M.SC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-2-277_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Problems of group differences inherent in traditional randomisation techniques highlighted in the editorial by Braitman (1) can be overcome by sophisticated randomisation procedures, which he did not address. Minimisation (2) assigns subjects entering a controlled trial to either group such as to ensure the best balance between the test/control groups at that point in time. It is particularly suited to the conduct of clinical trials in complex situations; we are using it in a controlled study of Imipramine as an adjuvant analgesic to morphine in pain due to advanced cancer. The criteria on which randomisation by this...References1. BRAITMAN L. Statistical, clinical, and experimental evidence in randomized controlled trials. Ann Intern Med. 1983;98:407-8. LinkGoogle Scholar2. TAVES D. Minimization: a new method of assigning patients to treatment and control groups. Clin Pharmacol Therap. 1974;15:443-53. CrossrefMedlineGoogle Scholar3. SIMON R. Restricted randomization designs in clinical trials. Biometrics. 1979;35:503-12. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1983Volume 99, Issue 2Page: 277-277KeywordsAnalgesicsClinical trialsMorphine Issue Published: 1 August 1983 PDF downloadLoading ...
Parainfluenza pneumonia in adults
Authors: R. P. Wenzel
Journal: JAMA (1972)

Parainfluenza virus, frequently a cause of respiratory disease in children, is uncommonly associated with illness in adults. A study sample of 160 incoming Marine Corps recruits showed that 25% to 48% had no detectable complement-fixing antibody to one or more of the three parainfluenza viruses. The remaining trainees had low levels of preexisting antibody. Five men were hospitalized with parainfluenzarelated pneumonia, including one with a moderate pleural effusion.
Bovine Spongiform Encephalopathy: Is It an Autoimmune Disease Due to Bacteria Showing Molecular Mimicry with Brain Antigens?
Authors: Alan Ebringer, John Pirt, Clyde Wilson, Phil Cunningham, Carlos Thorpe, Camille Ettelaie
Journal: Environmental Health Perspectives (1997)

Bovine spongiform encephalopathy (BSE) could be an autoimmune disease produced following exposure of cattle to feedstuffs containing bacteria showing molecular mimicry between bacterial components and bovine tissue. Analysis of molecular sequence databases (Genbank and SwissProt) shows that three bacteria (Acinetobacter calcoaceticus,Ruminococcus albus, and Agrobacter tumefaciens) share sequences with the encephalitogenic peptide of bovine myelin, while three molecules in Escherichia coli show molecular mimicry with host-encoded prion protein. Immune responses against these bacteria at both T and B cell levels may cause neurological tissue injury resembling BSE. The role of these bacteria in BSE, if any, merits further investigation.
<i>Transactions of the National Association for the Study of Epilepsy and the Care and Treatment of Epileptics</i>, at the first annual meeting, held in Washington, D. C., May 14 and 15, 1902. Edited by William Pryor Letchworth, LL. D. (C. E. Brinkworth, Buffalo, 1901.)
Journal: American Journal of Psychiatry (1902)
Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
Authors: Nigel J. Waterhouse, Vivien R. Sutton, Karin A Sedelies, Annette Ciccone, Misty Jenkins, Stephen J. Turner, Phillip I. Bird, Joseph A. Trapani
Journal: The Journal of Experimental Medicine (2006)
Future Leaders Recognized
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methylenetetrahydrofolate reductase (MTHFR) gene 677C&gt;T and 1298A&gt;C haplotypes: New prognostic factors in chronic lymphocytic leukemia
Authors: H. Nueckel, U. H. Frey, J. Duerig, U. Duehrsen, W. Siffert
Journal: Journal of Clinical Oncology (2004)

6524
Hepatic transcriptomic analysis identifies a mast cell gene expression signature that correlates with fibrosis stage and is prognostic in patients with primary sclerosing cholangitis
Authors: Michael Trauner, Yevgeniy Gindin, Jing Zhu Zhou, Jun Xu, Andrew Billin, Chuhan Chung, Mani Subramanian, Robert Myers, Atsushi Tanaka, Zachary Goodman, Andrew Muir, Douglas Thorburn, Christopher Bowlus, Cynthia Levy, Kris V. Kowdley
Journal: Journal of Hepatology (2020)
New York's First Medical School
Authors: Byron Stookey
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ALCOHOLIC NEURITIS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unusual abdominal gas collection
Authors: T. G. Goergen
Journal: JAMA (1978)

<h3>History</h3> A 54-year-old diabetic man had a fever for five days, decreasing mental status, and ketoacidosis. Pertinent laboratory data included the following values: WBC, 17,000/cu mm; blood glucose, 800 mg/dl; BUN, 49 mg/dl; and creatinine, 2.3 mg/dl. A spinal tap yielded purulent fluid from which<i>Escherichia coli</i>was cultured. Treatment with chloramphenicol was begun, but a temperature of 39 °C persisted. A urogram was performed two days later. Roentgenograms shown include a preliminary film of the abdomen (Fig 1) and a tomogram coned over the right renal area obtained immediately following injection of 100 ml of diatrizoate sodium and meglumine (Fig 2). There was normal excretion by the nonobstructed left kidney. Delayed films showed no excretion on the right. <h3>Diagnosis</h3> Emphysematous pyelonephritis with perinephric gas. <h3>Comment</h3> The preliminary film (Fig 1) shows a large reniform collection of gas distending the perirenal (Gerota) fascia. The tomogram (Fig 2) shows several smaller
Editorial: pregnancy with an intrauterine contraceptive device.
Authors: D Adams
Journal: BMJ (1975)

It is reported that when a woman with an IUD in situ becomes pregnant, she runs a high risk of infection and/or spontaneous abortion and of complication during pregnancy. About 1 in 5 pregnancies in which an IUD is present is ectopic. The most serious infections occur during the second trimester of pregnancy, and it is therefore suggested that the IUD be removed as soon as pregnancy is confirmed, before the tail of the device is drawn up inside the uterus, and that termination of pregnancy be discussed with the patient.
Transport in the liver Edited by D. Keppler and K. Jungermann. 258 pp. Dordrecht: Kluwer Academic Publishers, 1994. $75
Authors: R KOFF
Journal: Hepatology (1995)

The plant storage vacuole is involved in a wide variety of metabolic functions a great many of which necessitate the transport of substances across the tonoplast. Some solutes, depending on the origin, have to cross the plasma membrane as well. The cell is equipped with a complex web of transport systems, cellular routes, and unique intracellular environments that support their transport and accumulation against a concentration gradient. These are capable of processing a diverse nature of substances of distinct sizes, chemical properties, and origins. In this review we describe the various mechanism involved in solute transport into the vacuole of storage cells with special emphasis placed on solutes arriving through the apoplast. Transport of solutes from the cytosol to the vacuole is carried out by tonoplast-bound ABC transporters, solute/H+ antiporters, and ion channels whereas transport from the apoplast requires additional plasma membrane-bound solute/H+ symporters and fluid-phase endocytosis. In addition, and based on new evidence accumulated within the last decade, we re-evaluate the current notion of extracellular solute uptake as partially based on facilitated diffusion, and offer an alternative interpretation that involves membrane bound transporters and fluid-phase endocytosis. Finally, we make several assertions in regards to solute export from the vacuole as predicted by the limited available data suggesting that both membrane-bound carriers and vesicle mediated exocytosis are involved during solute mobilization.
The sad truth about hemodialysis in diabetic nephropathy
Authors: M. Ghavamian
Journal: JAMA (1972)

Nine patients with renal failure resulting from diabetic nephropathy were treated by hemodialysis. Average duration of diabetes was 21 years, and mean duration of nephropathy was 26 months. One patient survives after more than three years. Others survived for 9, 20, 19, and 13 months, respectively. Overall mortality was 78% at the end of one year. All patients had problems with clotting or infection of bloodstream access routes or both. All had further visual deterioration. Neuropathy was not accelerated. Muscle-wasting, hypoproteinemia, and fluid overload were common. Dialysis for such patients may be considered as a palliative measure with little likelihood of long-term survival or improvement in quality of life.
Angiosarcoma of the liver following vinyl chloride exposure
Authors: J. B. Block
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal