tbuckley/cabot-search huggingface dataset:
Zeitschrift für Kinderheilkunde, Berlin
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrigenda
Journal: British Journal of Dermatology (2006)

British Journal of DermatologyVolume 154, Issue 4 p. 807-807 Free Access Corrigenda First published: 08 March 2006 https://doi.org/10.1111/j.1365-2133.2006.07216.xAboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Efficacy of oral isotretinoin in the control of skin and nasal colonization by antibiotic-resistant propionbacteria in patients with acne. Br J Dermatol 2005, Coates et al. In the above mentioned article1 the Conflicts of Interest statement should have read as follows: ‘Conflicts of Interest: Prior to his retirement, WJ Cunliffe received fees and expenses from Roche (who manufacture and market oral Isotretinoin) and several other drug companies for lecturing and consultancy work. The Leeds Foundation for Dermatological Research (to which WJC was chairman and director) received similar funding.’ The authors apologize for this error. Assessment of the efficacy of ryosurgery in the treatment of granuloma faciale. Br J Dermatol 2006, Panagiotopoulos et al. In the above mentioned article21, 2 were printed in the incorrect order. They should have appeared as below. Figure 1Open in figure viewerPowerPoint Solitary reddish lesion of granuloma faciale. Figure 2Open in figure viewerPowerPoint Post-treatment resolution of the lesion. The authors apologize for this error. Mutation analysis in Irish families with glomuvenous malformations. Br J Dermatol 2005, O'Hagan et al. In the above mentioned article3 there was an error in the author listing. F. Maloney should have appeared as follows: F.J. Moloney The authors apologize for this error. References 1 Coates P, Vyakrnam S, Ravenscroft JC et al. Efficacy of oral isotretinoin in the control of skin and nasal colonization by antibiotic-resistant propionbacteria in patients with acne. Br J Dermatol 2005; 153: 1126– 1136. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 2 Panagiotopoulos A, Anyfantakis V, Rallis E et al. Assessment of the efficacy of ryosurgery in the treatment of granuloma faciale. Br J Dermatol 2006; 154: 360. Wiley Online LibraryWeb of Science®Google Scholar 3 O'Hagan AH, Maloney F, Buckley C et al. Mutation analysis in Irish families with glomuvenous malformations. Br J Dermatol 2006; 154: 450– 452. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Volume154, Issue4April 2006Pages 807-807 FiguresReferencesRelatedInformation
BUSINESS BEFORE HEALTH.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2179: Antitumor activity of JNJ-63576253 (TRC253), a small molecule antagonist of F877L mutant and wild-type androgen receptor
Authors: Tammy L. Bush, Georges Habineza Ndikuyeze, Gilles Bignan, Jonathan Branch, Janine Ondrus, Yifan Shi, Leopoldo Luistro, James Hastings, Joseph Erhardt, Ian Hickson, Shefali Patel, Peter Connolly, Zhuming Zhang, James Bischoff, Brent Rupnow, Marco Gottardis, Kathryn Packman
Journal: Cancer Research (2019)

Abstract Androgen receptor (AR) antagonists have transformed prostate cancer patient care by targeting a key nodal point in tumor cell signaling. However, despite the impressive clinical activity of first- and second-generation antiandrogens, acquired resistance frequently emerges. Point mutations in the ligand-binding domain of AR, such as phenylalanine to leucine at position 877 (ARF877L), account for 10-20% of resistance. Such mutations are characterized by receptor activation, rather than inhibition, by first- and second-generation antiandrogen therapeutics. JNJ-63576253 is a potent, high affinity competitive binder of wild type and mutant AR, including F877L. JNJ-63576253 blocks AR nuclear translocation, AR binding to DNA, and AR-dependent transcription. JNJ-63576253 inhibits the proliferation of androgen receptor driven prostate cancer cell lines, including those bearing ARF877L. In the Hershberger assay in male Sprague Dawley rats, oral administration of JNJ-63576253 inhibited androgen sensitive organ (ASO) development in a dose-dependent manner. In male SHO mice bearing LNCaP xenografts with either wild-type or ARF877L, daily treatment with 30 mg/kg JNJ-63576253 treatment resulted in statistically significant antitumor activity, whereas second-generation antiandrogen enzalutamide had no antitumor efficacy in the LNCaP ARF877L mutant model. Janssen and Tracon Pharma have entered a strategic licensing collaboration, whereby Tracon possesses exclusive rights for clinical development of JNJ-63576253 (now called TRC253). Tracon has entered TRC253 into Ph1/2A clinical evaluation in metastatic castration-resistant prostate cancer patients. Citation Format: Tammy L. Bush, Georges Habineza Ndikuyeze, Gilles Bignan, Jonathan Branch, Janine Ondrus, Yifan Shi, Leopoldo Luistro, James Hastings, Joseph Erhardt, Ian Hickson, Shefali Patel, Peter Connolly, Zhuming Zhang, James Bischoff, Brent Rupnow, Marco Gottardis, Kathryn Packman. Antitumor activity of JNJ-63576253 (TRC253), a small molecule antagonist of F877L mutant and wild-type androgen receptor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2179.
THE RECTAL THERMOMETER
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeting CD137 enhances the efficacy of cetuximab
Authors: Holbrook E. Kohrt, A. Dimitrios Colevas, Roch Houot, Kipp Weiskopf, Matthew J. Goldstein, Peder Lund, Antonia Mueller, Idit Sagiv-Barfi, Aurelien Marabelle, Ruth Lira, Emily Troutner, Lori Richards, Amanda Rajapaska, Jonathan Hebb, Cariad Chester, Erin Waller, Anton Ostashko, Wen-Kai Weng, Lieping Chen, Debra Czerwinski, Yang-Xin Fu, John Sunwoo, Ronald Levy
Journal: Journal of Clinical Investigation (2019)
Compulsory treatment of the mentally ill.
Journal: BMJ (1986)

Two recent court decisions interpreted Britain's Mental Health Act 1983 as not authorizing compulsory treatment of patients who are not detained in a hospital as inpatients. Health personnel are thus unable to intervene until a deteriorating condition justifies detention. In one case, Ex parte W, physicians admitted a patient for one night in order to grant her a leave of absence to be treated as an outpatient. Since it was acknowledged that she did not require inpatient care, the detention was ruled unlawful. In a second case, Ex parte L, a lawfully detained patient was treated as an outpatient under a leave of absence with liability for detention. When the authority for detention was renewed, it was stipulated that the patient's treatment be continued but that hospitalization was not necessary. On that basis, the court declared the renewal unlawful.
Lithium in Breast Milk and Nursing Infants: Clinical Implications
Authors: Adele Viguera
Journal: American Journal of Psychiatry (2007)

Objective: Current practice guidelines discourage use of lithium during breast-feeding, despite limited data. This study aimed to quantify lithium exposure in nursing infants. Method: In 10 mother-infant pairs, the authors obtained assays of lithium in maternal serum, breast milk, and infant serum and indices of infant renal and thyroid function. Results: Maternal serum, breast milk, and infant serum daily trough concentrations of lithium averaged 0.76, 0.35, and 0.16 meq/liter, respectively, each lithium level lower than the preceding level by approximately one-half. No serious adverse events were observed, and elevations of thyroid-stimulating hormone, blood urea nitrogen, and creatinine were few, minor, and transient. Conclusions: Serum lithium levels in nursing infants were low and well tolerated. No significant adverse clinical or behavioral effects in the infants were noted. These findings encourage reassessment of recommendations against lithium during breast-feeding and underscore the importance of close clinical monitoring of nursing infants.
The need to redefine levels of surgical care
Authors: J. E. Davis
Journal: JAMA (1984)

IN RECENT years, both the number and variety of surgical procedures performed on nonhospitalized patients have increased markedly. These procedures are now being accomplished safely and without increased risk to patients. This method of avoiding hospitalization for patients with surgical problems of even intermediate magnitude is cost-effective, readily accepted by patients, and has improved the efficiency of surgical care delivery throughout the nation. However, the classification and differentiation of these patients and the operations they receive are unclear, and much confusion results.<sup>1</sup>We have an urgent need to redefine the levels of surgical care that we so competently provide. Until recently, all surgical care was thought of as being provided either on an inpatient or outpatient basis, obviously determined by whether or not the patient was admitted to the hospital. In the last decade, major advances in surgical and anesthetic techniques, shorteracting anesthetic agents, the advent of milder yet adequate
CORRECT DEFINITION OF "APOPLEXY"
Authors: None H. G. W.
Journal: JAMA (1924)

<h3>To the Editor:</h3> —On March 11, 1922, you published an editorial calling attention to the misuse of the word "apoplexy" by medical writers, noting the fact that the word refers to the loss of consciousness and paralysis. On page 763 of the issue of May 31, 1924, you have a report on "Apoplexy of the Breast." [Note.—Thank you! The point is well taken. However, the dictionary now defines "apoplexy," by common usage, "copious extravasation of blood into any organ." Strictly speaking, the term should be used to refer only to hemorrhage into the brain or spinal cord.—Ed.]
Cystinosis
Authors: Lloyd H. Smith
Journal: JAMA (1973)

The last two decades have witnessed a remarkable burst of interest in the genetic diseases, with biochemical elucidations following close on clinical descriptions. The major problem for the investigator has usually been that of discovering a biochemical marker in order to focus more sharply on the site of the presumed genetically determined defect in a protein. Once the marker is found, it has not been difficult in most genetic disorders to narrow the range of pathogenetic possibilities sharply, using current knowledge of normal metabolic pathways in mammalian systems. Cystine crystals were found in an autopsied child 70 years ago. Over the succeeding years this amino acid storage disease was clearly separated from cystinuria, a selective disorder of transport of specific amino acids in the kidney and the gut. The normal pathways for the metabolism of sulfur amino acids have been studied extensively. It would therefore seem to be a relatively
Pleurectomy for congenital heart disease
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anthrax Infection
Authors: Daniel A. Sweeney, Caitlin W. Hicks, Xizhong Cui, Yan Li, Peter Q. Eichacker
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Bacillus anthracis infection is rare in developed countries. However, recent outbreaks in the United States and Europe and the potential use of the bacteria for bioterrorism have focused interest on it. Furthermore, although anthrax was known to typically occur as one of three syndromes related to entry site of (i.e., cutaneous, gastrointestinal, or inhalational), a fourth syndrome including severe soft tissue infection in injectional drug users is emerging. Although shock has been described with cutaneous anthrax, it appears much more common with gastrointestinal, inhalational (5 of 11 patients in the 2001 outbreak in the United States), and injectional anthrax. Based in part on case series, the estimated mortalities of cutaneous, gastrointestinal, inhalational, and injectional anthrax are 1%, 25 to 60%, 46%, and 33%, respectively. Nonspecific early symptomatology makes initial identification of anthrax cases difficult. Clues to anthrax infection include history of exposure to herbivore animal products, heroin use, or clustering of patients with similar respiratory symptoms concerning for a bioterrorist event. Once anthrax is suspected, the diagnosis can usually be made with Gram stain and culture from blood or surgical specimens followed by confirmatory testing (e.g., PCR or immunohistochemistry). Although antibiotic therapy (largely quinolone-based) is the mainstay of anthrax treatment, the use of adjunctive therapies such as anthrax toxin antagonists is a consideration.
Sunlamps and the risk of melanoma.
Journal: BMJ (1988)

and not be limited to conventions.Classical power determination does use a single alternative hypothesis, but power of the test is even greater if the true difference is larger than the posited clinically important difference.We think that Bayesian approaches offer great potential.As presently developed, however, the Bayesian method is difficult even for Bayesian statisticians and requires more research before it becomes practical.Development of Bayesian in- ference instruments that are easily employed by clinicians would greatly advance the usefulness of the Bayesian approach.
In This Issue
Journal: Journal of Clinical Investigation (2010)

N-WASP helps hair growthMany physiological processes in the skin, including wound healing and hair follicle (HF) cycling, involve actin cytoskeleton reorganization regulated by the Rho family GTPases Cdc42 and Rac1.Consistent with this, aberrant regulation of the cytoskeleton is associated with various human skin disorders.In this issue (446)(447)(448)(449)(450)(451)(452)(453)(454)(455)(456), Lyubimova and colleagues have determined that neural Wiskott-Aldrich syndrome protein (N-WASP), which acts downstream of Cdc42 to regulate actin cytoskeleton reorganization, has a key role in skin function and HF cycling, by generating and analyzing mice lacking N-WASP in skin.Analysis of the mice indicated that N-WASP is critical for keratinocyte proliferation and hair growth but is dispensable for epidermal differentiation and wound healing.The role of N-WASP in hair growth was found to be a result of its key role in HF cycling and in the maintenance and differentiation of HF progenitor cells.As N-WASP deficiency resulted in decreased nuclear localization of β-catenin in follicular keratinocytes and decreased Wnt-dependent transcription, the authors suggest that N-WASP promotes β-catenin-dependent transcription, thereby promoting the differentiation of HF progenitor cells.
Allied Health Education
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"A NOTED DIVINE" AND "CHRISTIAN SCIENCE."
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Postexercise phonocardiogram. Thirty-month follow-up in normal subjects
Authors: W. S. Aronow
Journal: JAMA (1974)

One hundred clinically normal subjects who had resting and postexercise phonocardiograms recorded at rest and after a double Master two-step exercise test in the supine and left lateral decubitus positions were followed up for 30 months. In four patients coronary artery disease developed within 30 months. The resting or postexercise third or fourth heart sound recorded in the supine or left lateral decubitus position did not correlate significantly with subsequent development of coronary artery disease. (<i>JAMA</i>228:1569-1570, 1974)