tbuckley/cabot-search huggingface dataset:
Febrile neutropenia
Authors: J. D. Naik, S. R. K. Sathiyaseelan, N. S. Vasudev
Journal: BMJ (2010)

<h3>ABSTRACT</h3> <h3>Objective</h3> Here, we leveraged the ongoing, large-scale Child Mind Institute Healthy Brain Network, a transdiagnostic self-referred, community sample of children and adolescents (ages 5-21), to examine the associations between Problematic Internet Use (PIU) and psychopathology, general impairment, physical health and sleep disturbances. <h3>Methods</h3> A total sample of 564 (190 female) participants between the ages of 7-15 (mean = 10.80, SD = 2.16), along with their parents/guardians, completed diagnostic interviews with clinicians, answered a myriad of self-report questionnaires, and underwent physical testing as part of the Healthy Brain Network protocol. <h3>Results</h3> PIU was positively associated with depressive disorders (aOR = 2.34; CI: 1.18-4.56; p = .01), the combined subtype of ADHD (aOR = 1.79; CI: 1.08-2.98; p = .02), greater levels of impairment (Standardized Beta = 4.79; CI: 3.21-6.37; p &lt; .01) and increased sleep disturbances (Standardized Beta = 3.01; CI: 0.58-5.45; p = .02), even when accounting for demographic covariates and psychiatric comorbidity. <h3>Conclusion</h3> The association between PIU and psychopathology, as well as its impact on impairment and sleep disturbances, highlight the urgent need to gain an understanding of mechanisms in order to inform public health recommendations on internet use in U.S. youth.
Parkinson's Syndrome
Authors: Albert C. England, Robert S. Schwab
Journal: New England Journal of Medicine (1961)

THE devastating illness to which James Parkinson called attention in 1817 has received a good deal of attention in the past ten years. Pharmaceutical chemists have developed rather a large number of compounds with varying degrees of effectiveness against some of the symptoms. A brilliant development of neurosurgical procedures aimed at the selective destruction of several basal-ganglion nuclear centers has also occurred. Perhaps this dramatic amelioration of tremor and rigidity by surgery has been the largest factor accounting for a resurgence of interest a hundred and forty-three years after the appearance of Parkinson's excellent clinical description.PathologyThere has been . . .
Interventionen
Authors: Johannes Görich
Journal: Thorax (2003)

Die in Diagnostik und Therapie wichtigen Interventionstechniken werden mit ihren Besonderheiten und Modifikationen hinsichtlich ihrer Vorbereitung, Durchführung und Nachsorge dargestellt. Es wird ein ÖUberblick über die Indikationen für die Feinnadelaspirationsbiopsie und die Stanzbiopsie von Lungenrundherden, für Drainagen sowie für die Embolisation arteriovenöser Malformationen und die Implantation tracheobronchialer Stents gegeben. Zu den Ergebnissen der interventionellen Maßnahmen werden auch die Komplikationen durch Material und Vorgehensweise im Zusammenhang mit der jeweiligen Grunderkrankung beschrieben.
Abstract 2707: The Magnitude of Health Care Resource Utilization by Medicare Beneficiaries with Heart Failure
Authors: Robert L Page, Kara B Strongin, Roger M Mills, Christopher Hogan, JoAnn Lindenfeld
Journal: Circulation (2007)

Introduction: By 2010, the number of individuals ≥ 65 years with a heart failure (HF) diagnosis should increase by an additional 700,000. As the financial burden of HF is expected to substantially increase, we examined health care expenditures of Medicare beneficiaries with HF to estimate the current healthcare costs and resource allocation. Methods: An analysis of 2005 Medicare claims was conducted, using a 5% sample standard analytic and denominator file, limited data set version to extrapolate the 34,150,200 Medicare beneficiaries. The cohort was defined by the Centers for Medicare and Medicaid Services Hierarchical Condition Categories Model which requires one HF diagnosis from a physician or hospital outpatient department/inpatient bill. HMO enrollees, persons without Part A and Part B coverage, and those outside the United States were excluded. Results: Based on inclusion criteria, 260,076 beneficiaries were identified. Beneficiaries with HF accounted for 13% of the total beneficiary population and 37% of all Medicare spending. Reimbursement for hospital inpatient admissions, physician visits, and hospital outpatient visits accounted for $12,556; $5,875; and $2,753 per-capita, respectively. In one year, 22% of all beneficiaries required hospitalization compared to 59% of beneficiaries with HF. Thirty-one percent of beneficiaries with HF had ≥ 2 inpatient admissions. Twenty-four percent of all hospital discharges were for HF, either as a principal diagnosis or co-morbidity, accounting for $30.4 billion. On average, 8.3 different outpatient and inpatient providers ordered services for a single beneficiary. Beneficiaries with at least two prior HF hospitalizations within the index period had on average 3.04 physician visits every three months. Only 26% of these visits were conducted by a cardiologist. Conclusion : Medicare beneficiaries with HF impose a tremendous burden on Medicare, consisting of over one-third of Medicare spending. It will be important to determine how much of this burden is due to HF and how much to comorbid conditions. Development of specialized Medicare HF Management Programs, also providing comprehensive care for co-morbidities, could curtail these admissions and potentially reduce costs.
Uncritical thinking in medicine. The confusion between hypothesis and knowledge
Authors: M. H. Dykes
Journal: JAMA (1974)

NO ONE involved in providing health care, whether a professional or a patient, would disagree that the primary goal of the system is maintenance of the health of the patient. A corollary of this position is the assertion that ideally every prophylactic or therapeutic maneuver should have a greater chance of improving rather than of worsening the health of the patient. While it is easy to make this assertion, a number of factors have ensured that in practice it may be extremely difficult for a physician to be certain that a specific clinical maneuver is indeed indicated for a specific patient. Ingelfinger<sup>1</sup>has succinctly defined the ingredients that distinguish the good physician as "the exercise of well based and independent clinical judgment." Although this communication will address itself to a discussion of problems inherent in deciding what is or is not a well-based therapeutic maneuver, it is not intended
Paraganglioma (chemodectoma) of the middle ear and mastoid
Authors: K. M. Simonton
Journal: JAMA (1968)

Paraganglion bodies exist in the region of the middle ear as well as in other regions of the body. Tumors of this tissue occur in the ear and adjacent tissues. The symptoms and the extent of the tumor at diagnosis are largely dependent on the site of the paraganglion from which the tumor arises. The tumor in the ear has been recognized as an entity only recently. Much remains to be known of its natural history and of its response to therapy, and there exists diversity of opinion concerning the optimal method of treatment. Five patients showed varied response to irradiation therapy. The clinical course in one of these patients indicates cessation of growth after inadequate therapy. In contrast, two patients give evidence of continued tumor growth after irradiation therapy.
Environmental Exposure to Volatile Organic Compounds among Workers in Mexico City as Assessed by Personal Monitors and Blood Concentrations
Authors: Isabelle Romieu, Matiana Ramirez, Fernando Meneses, David Ashley, Sharon Lemire, Steve Colome, Kochy Fung, Mauricio Hernandez-Avila
Journal: Environmental Health Perspectives (1999)

Benzene, an important component in gasoline, is a widely distributed environmental contaminant that has been linked to known health effects in animals and humans, including leukemia. In Mexico City, environmental benzene levels, which may be elevated because of the heavy traffic and the poor emission control devices of older vehicles, may pose a health risk to the population. To assess the potential risk, portable passive monitors and blood concentrations were used to survey three different occupational groups in Mexico City. Passive monitors measured the personal exposure of 45 workers to benzene, ethylbenzene, toluene, o-xylene and m-/p-xylene during a work shift. Blood concentrations of the above volatile organic compounds (VOCs), methyl tert-butyl ether, and styrene were measured at the beginning and the end of a work shift. Passive monitors showed significantly higher (p > 0.0001) benzene exposure levels among service station attendants (median = 330 microg/m3; range 130-770) as compared to street vendors (median = 62 microg/m3; range 49-180) and office workers (median = 44 microg/m3, range 32-67). Baseline blood benzene levels (BBLs) for these groups were higher than those reported for similar populations from Western countries (median = 0.63 microg/L, n = 24 for service station attendants; median = 0.30 microg/L, n = 6 for street vendors; and median = 0.17 microgr;g/L, n = 7 for office workers). Nonsmoking office workers who were nonoccupationally exposed to VOCs had BBLs that were more than five times higher than those observed in a nonsmoking U.S. population. BBLs of participants did not increase during the work shift, suggesting that because the participants were chronically exposed to benzene, complex pharmacokinetic mechanisms were involved. Our results highlight the need for more complete studies to assess the potential benefits of setting environmental standards for benzene and other VOCs in Mexico.
Ph.d Theses and Book Reviews
Journal: British Journal of Dermatology (1976)

British Journal of DermatologyVolume 95, Issue 4 p. 453-456 Ph.d Theses and Book Reviews First published: October 1976 https://doi.org/10.1111/j.1365-2133.1976.tb00851.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat SUMMARY Book reviewed in this article: The differentiation of dermatophytes by biochemical and serological methods. CHRISTINE M.PHILPOT (1976) The role of bacteria in acne vulgaris. C.D.ROBERTS (1976) Dermatology. S.L.MOSCHELLA, D.M.PILLSBURY and H.J.HURLEY (1975) Dermatology. HANS RORSMAN (1976) Skin care. BETHEL SOLOMONS (1975) Varizen—Ulcus cruris und Thrombose. KARL SIGG (1976) Volume95, Issue4October 1976Pages 453-456 RelatedInformation
Reduced Sleep Spindle Activity in Schizophrenia Patients
Authors: Fabio Ferrarelli
Journal: American Journal of Psychiatry (2007)

Objective: High-density EEG during sleep represents a powerful new tool to reveal potential abnormalities in rhythm-generating mechanisms while avoiding confounding factors associated with waking activities. As a first step in this direction, the authors employed high-density EEG to explore whether sleep rhythms differ between schizophrenia subjects, healthy individuals, and a psychiatric control group with a history of depression. Method: Healthy comparison subjects (N=17), medicated schizophrenia patients (N=18), and subjects with a history of depression (N=15) were recruited. Subjects were recorded during the first sleep episode of the night with a 256-electrode high-density EEG. Recordings were analyzed for changes in EEG power spectra, power topography, and sleep-specific cortical oscillations. Results: The authors found that the schizophrenia group had a significant reduction in centroparietal EEG power, from 13.75 to 15.00 Hz, in relation to both the comparison and depression groups. No significant difference in EEG power between the comparison and depression groups was identified. The authors also found a decrease in sleep spindle number, amplitude, duration, and integrated spindle activity in schizophrenia patients. Furthermore, integrated spindle activity had an effect size corresponding to 93.0% or 90.2% separation of the schizophrenia from the comparison or depression group. Conclusions: Sleep spindles are generated by the thalamic reticular nucleus in conjunction with specific thalamic nuclei and are modulated by corticothalamic and thalamocortical connections. The deficit in sleep spindles in schizophrenia subjects may reflect dysfunction in thalamic-reticular and thalamocortical mechanisms and could represent a biological marker of illness.
Anesthesiologists Expand Their Role in Therapy Through Research
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious Mononucleosis in Children
Authors: Charles M. Ginsburg
Journal: JAMA (1977)

Epstein-Barr virus (EBV)-specific antibody responses were determined in 43 consecutive pediatric patients who had signs and symptoms of infectious mononucleosis (IM) and positive diagnostic tests for mononucleosis (Monospot). Thirty patients gave clear-cut serologic evidence of primary EBV infections; of the remaining 13 patients, seven had no antibodies to EBV in the acute- or convalescent-phase sera and six showed serologic patterns of past EBV infections. Further testing proved that the initial Monospot results were either false-positive or were incorrectly interpreted in all 13 patients with unidentifiable illnesses but in only two of the patients with current EBV infections. The data confirm the occurrence of classical IM in children and show that the disease and the EBV-specific antibody responses can be virtually indistinguishable from adult cases. (<i>JAMA</i>237:781-785, 1977)
<i>Erratum</i>: Vol. 66, No. 5
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

In the report "Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older - United States, 2017," on page 138, the fifth bullet point under the heading "Meningococcal vaccination" should have read "Young adults aged 16 through 23 years (preferred age range is 16 through 18 years) who are healthy and not at increased risk for serogroup B meningococcal disease may receive either a 2-dose series of MenB-4C at least 1 month apart or a 2-dose series of MenB-FHbp at 0 and 6 months for short-term protection against most strains of serogroup B meningococcal disease."
Highlights
Authors: Gursant Atwal, Adnan Siddiqui
Journal: JAMA Neurology (2017)

Mechanical Thrombectomy Instead of IVT With MT for AIS 268Mechanical thrombectomy (MT) improves clinical outcomes in patients with acute ischemic stroke (AIS) caused by a large vessel occlusion.However, it is not known whether intravenous thrombolysis (IVT) is of added benefi t in patients undergoing MT.Coutinho et al examined whether treatment with IVT before MT with a stent retriever is benefi cial in patients undergoing MT.Their results indicate that treatment of patients experiencing AIS due to a large vessel occlusion with IVT before MT does not appear to provide a clinical benefi t over MT alone.A randomized clinical trial seems warranted.
Tent Life and Simplicity in Treatment of Phthisis Pulmonalis.Corneal Disease Due to Smallpox.A New Operating Table.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ELECTRICITY IN THE TREATMENT OF FIBROID TUMORS.
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 27: Identification and characterization of a novel dual FLT3/microtubule polymerization inhibitor through cell-based screening
Authors: Haleema Sadia Malik, Aishah Bilal, Rahim Ullah, Maheen Iqbal, Rahman Shah Saleem, Hidayat Hussain, Amir Faisal
Journal: Cancer Research (2019)

Abstract Activating mutations in FLT3 receptor tyrosine kinase are found in one-third of acute myeloid leukemia (AML) patients and are associated with disease relapse and bad prognosis. Majority of these mutations are Internal tandem duplications (ITD) in the juxtamembrane domain of FLT3 and have been validated as a therapeutic target. Clinical success of selective inhibitors targeting oncogenic FLT3, however, has been limited due to the acquisition of drug resistance. Here we report the identification of a dual FLT3/microtubule polymerization inhibitor, HH-IA-208, through cell-based screenings for the differential killing of leukemia cell lines expressing FLT3-ITD (MV411) or BCR-ABL (K562) using an MTS proliferation assay and for mitotic inducers using a dot-blot assay for histone H3 phosphorylation in HCT116 cell line. HH-IA-208, a chalcone derivative, inhibits FLT3 in vitro and treatment of FLT3-ITD+ cell lines with HH-IA-208 results in reduced FLT3 signaling. Similarly, HH-IA-208 inhibits tubulin polymerization in a biochemical assay and in cells that results in a mitotic arrest. HH-IA-208 is selectively more potent in leukemia cell lines expressing FLT3-ITD and treatment for 24 and 48 hours with the inhibitor results in apoptotic cell death. Furthermore, HH-IA-208 is able to overcome TKD mutation-mediated acquired resistance to FLT3 inhibitors in a MOLM13 cell line expressing FLT3-ITD with the D835Y mutation. HH-IA-208, therefore, is a promising lead for the discovery of dual target FLT3 inhibitors that can overcome resistance to selective FLT3 inhibitors. Citation Format: Haleema Sadia Malik, Aishah Bilal, Rahim Ullah, Maheen Iqbal, Rahman Shah Saleem, Hidayat Hussain, Amir Faisal. Identification and characterization of a novel dual FLT3/microtubule polymerization inhibitor through cell-based screening [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 27.
Type A behavior pattern and coronary angiographic findings
Authors: K. A. Frank
Journal: JAMA (1978)

One hundred forty-seven consecutive patients scheduled to undergo coronary angiography were classified according to the type-A behavior pattern. Statistically significant correlations were found between disease severity and the physical risk factors cholesterol, smoking, hypertension, sex, and age. The correlation of the behavior pattern with angiographic disease severity was of the same magnitude as that of the other risk factors except cholesterol, which was greater. The association between the behavior pattern and severity persisted after adjustments had been made for the effects of five other major risk factors. (<i>JAMA</i>240:761-763, 1978)
SKIN CANCER
Authors: Lester Hollander
Journal: JAMA (1952)

<h3>To the Editor:</h3> —In the 20 year period from Jan. 1, 1932, to Dec. 31, 1951, of all the skin lesions that I excised and submitted for pathological examination positive evidence of carcinoma of the skin was found in 2,465 persons. The primary local nature of cancer of the skin in its early stage is often emphatically stated in both lay and medical communications. A review of the material mentioned above suggests the exigency of a less confident attitude in this respect. A brief summary based on these cases gives proof that, in a reasonably large number of cases, skin cancer, contrary to popular belief, is not a local phenomenon. Two or more anatomically widely separated areas in the same patient were found not infrequently to serve as independent cancer beds. No recognized manner of extension or metastasis from one cancer to the other or others was demonstrable. Malignant melanomas