tbuckley/cabot-search huggingface dataset:
Abstract 2083: Five-Year Follow-Up of Quality of Life in Randomized Patients to Receive Coronary Bypass Surgery, Percutaneous Coronary Intervention or Medical Treatment: The Medicine Angioplasty or Surgery Study (MASS-II) Trial
Authors: Myrthes E Takiuti, Priscyla Girardi, Celia R Nogueira, Teryo Nakano, Felipe S Paulitsch, Cibele L Garzillo, Neuza Lopes, Noedir A Stolf, Whady Hueb
Journal: Circulation (2008)

Background: Although coronary bypass surgery (CABG), percutaneous coronary intervention (PCI) are used for the relief of symptoms and for a better tolerance to exercises, there is no conclusive evidence showing that these methods offer more benefits than the medical treatment (MT) to the quality of life (QoL) in patients with symptomatic coronary artery disease (CAD). This study sought to compare the QoL scores during 5-year in patients with stable multivessel CAD, who underwent one of the 3 therapeutic approaches. Methods: From May 2000 and May 2005 a total of 611 patients were randomly assigned to a CABG (n=203), PCI (n=205) or MT (n=203). Of these patients, 546 (89%) were followed for assessments of QoL and demographic profile questionnaire for a 5-year period. 187 (34%) underwent CABG, 181 (33 %) PCI and 178 (33%) underwent MT. The Short Form Health-Related QoL Questionnaire (SF-36) was used to assess the patients, before randomization, six months, and 12months and annually until the end of study. The SF-36 comprises 36 items that can be combined into the following eight multi-item summary scores: physical functioning, vitality, bodily pain, mental heath, social functioning, and role limitation due to physical health, emotional problems and general health perceptions. Results: At baseline, we found no difference relating to overall mortality between three groups. The eight domains of QoL showed improvement in all groups at 6-month follow-up visit compared with the baseline evaluation (p&lt;0.001). Surgical therapy, PCI and MT showed improvements over baseline in most domains of quality of life (p&lt;0.001). The improvements was observed mainly in surgical group and especially in physical role functioning. On the other hand medical therapy group showed fewer changed in their rating of general health. PCI group showed significant superiority over medical group in terms of physical functioning, vitality and general health after randomization. Conclusion: All patients had improvement in QoL detected at 6 months persisting until 60 months. Moreover, CABG patients had better improvement of QoL compared with other groups. Furthermore, the QoL of PCI patients was better than MT patients at the end of follow-up.
Endotracheal tube compression demonstrated by roentgenogram
Authors: G. W. Dietz
Journal: JAMA (1968)

Endotracheal tubes have been used with increasing frequency to avoid the use of tracheostomies in patients with respiratory depression. Use of the tubes seems justified in decreasing patient morbidity when an episode of respiratory depression is transient or when episodes of respiratory failure are unlikely to recur. The use of endotracheal tubes, however, may be associated with certain complications with which the attending physician should be familiar.<sup>1-5</sup>This communication describes one such complication, namely, the tendency of some types of endotracheal tubes to collapse and thus obliterate the lumen when the cuff is excessively inflated. <h3>Report of a Case</h3> A 42-year-old woman was admitted to a local hospital with a one-week history of increasing cough, yellow sputum, and dyspnea, all of which were unresponsive to antibiotics. She had had a long-standing cough and exertional dyspnea despite a lower lobectomy on the right side in 1960 for bronchiectasis. On examination,
Diseases of the Nervous System. A Text-book for Students and Practitioners of Medicine. By H. Oppenheim, Professor of the University of Berlin.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NIMG-05. RADIOGENOMICS TO CHARACTERIZE REGIONAL GENETIC HETEROGENEITY IN GLIOBLASTOMA
Authors: Leland Hu, Shuluo Ning, Jennifer Eschbacher, Leslie Baxter, Nathan Gaw, Sara Ranjbar, Jonathan Plasencia, Amylou Dueck, Sen Peng, Kris Smith, Peter Nakaji, John Karis, Christopher Quarles, Teresa Wu, Joseph Loftus, Robert Jenkins, Hugues Sicotte, Thomas Kollmeyer, Brian O’Neill, William Elmquist, Joseph Hoxworth, David Frakes, Jann Sarkaria, Kristin Swanson, Nhan Tran, Jing Li, Ross Mitchell
Journal: Neuro-Oncology (2016)

Glioblastoma (GBM) exhibits profound intratumoral genetic heterogeneity. Each tumor comprises multiple genetically distinct clonal populations with different therapeutic sensitivities. This has implications for targeted therapy and genetically informed paradigms. Contrast-enhanced MRI (CE-MRI) and conventional sampling techniques fail to resolve this heterogeneity, particularly for non-enhancing tumor populations. This study explores the feasibility of using multi-parametric MRI and texture analysis to characterize regional genetic heterogeneity throughout MRI-enhancing and non-enhancing tumor segments. We collected multiple image-guided biopsies from primary GBM patients throughout regions of enhancement (ENH) and non-enhancing parenchyma, so called brain-around-tumor (BAT). For each biopsy, we analyzed DNA copy number variants for core GBM driver genes reported by The Cancer Genome Atlas. We coregistered biopsy locations with MRI and texture maps to correlate regional genetic status with spatially matched imaging measurements. We also built multivariate predictive decision tree models for each GBM driver gene and validated accuracies using leave-one-out-cross-validation (LOOCV). We collected 48 biopsies (13 tumors) and identified significant imaging correlations (univariate analysis) for six driver genes: EGFR, PDGFRA, PTEN, CDKN2A, RB1, TP53. Predictive model accuracies (on LOOCV) varied by driver gene of interest. Highest accuracies were observed for PDGFRA (77.1%), EGFR (75%), CDKN2A (87.5%), and RB1 (87.5%), while lowest accuracy was observed in TP53 (37.5%). Models for 4 driver genes (EGFR, RB1, CDKN2A, PTEN) showed higher accuracy in BAT samples (n=16) compared with those from ENH segments (n=32). MRI and texture analysis can help characterize regional genetic heterogeneity, which offers potential diagnostic value under the paradigm of individualized oncology.
Transtracheal ventilation
Authors: R. R. Attia
Journal: JAMA (1975)

Effective percutaneous oxygenation and ventilation can be achieved through the use of transtracheal catheters. A graphic study of pressure-flow requirements through different-sized catheters can serve as a guide for the caliber and driving pressure requirement to obtain optimal oxygen flow. (<i>JAMA</i>234:1152-1153, 1975)
Ehrlich and Von Behring
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Olfactory Stimulation Selectively Modulates the OFF Pathway in the Retina of Zebrafish
Authors: Federico Esposti, Jamie Johnston, Juliana M. Rosa, Kin-Mei Leung, Leon Lagnado
Journal: Neuron (2013)

(Neuron 79, 97–110; July 10, 2013) On page 103 of this paper, the text mistakenly reads as follows: “Addition of 10μM dopamine increased G’max by 44% ± 11% and shifted V1/2 from −14.2 ± 0.4 mV to −16.5 ± 0.4 mV (Figure 7F, p = 0.002).” The text should instead read: “Addition of 10μM dopamine increased G’max by 44% ± 11% and shifted V1/2 from −24.2 ± 0.4 mV to −26.5 ± 0.4 mV (Figure 7F, p = 0.002).” On page 106, the axis in Figure 7C top panel shows wrong values; the right values are reported in the following figure shown here. Olfactory Stimulation Selectively Modulates the OFF Pathway in the Retina of ZebrafishEsposti et al.NeuronJuly 10, 2013In BriefEsposti et al. show that olfactory stimulation selectively modulates synaptic transmission from retinal OFF bipolar cells in zebrafish. Dopamine plays a key role in this cross modal interaction by acting on the presynaptic calcium channels. Full-Text PDF Open Access
Abstract 19529: Risk of Sudden Cardiac Arrest According to the Month of STEMI Occurrence: The e-MUST Study
Authors: Nicole Karam, Muriel Tafflet, Sophie Bataille, Eloi Marijon, Jean Philippe empana, Christian Spaulding, Yves Lambert, Xavier jouven
Journal: Circulation (2015)

STEMI mortality decreased drastically during the last decades, and out-of-hospital sudden cardiac arrest (SCA) has become its main cause of death. The risk of SCA according to the month of STEMI occurrence has not been assessed. Hypothesis: The risk of SCA varies according to the month of STEMI occurrence. Methods: Data were taken from a prospective pre-hospital study (e-MUST study) on STEMI patients managed by emergency medical services in Paris and its suburbs between January 2006 and December 2010. In this area, emergency calls are routed to the closest dispatch center and regulated by physicians who send an ambulance with a physician on board in case of suspected acute myocardial infarction. Pre-hospital EKGs are obtained for all patients and those presenting STEMI are included in the study. We assessed and compared the rate of SCA according to the month of STEMI occurrence. Results: Among the 8112 STEMI patients enrolled (mean age (SD) 61.6years (14.3), 78% males), 452 patients (5.6%) developed out-of-hospital SCA. We observed significant temporal changes in the rate of SCA per STEMI over the year. The peak rate of SCA per STEMI occurred in June (8.7%), while the lowest rate was in December (3.45%) (Figure). Conclusions: The risk of SCA varies significantly according to the month of STEMI occurrence, with STEMI occurring in June being at the highest risk for SCA while those occurring in December have the lowest risk. A better understanding of the pathophysiological mechanisms of this difference is needed to eventually reduce the risk of out-of-hospital SCA after STEMI diagnosis.
Secondary Gout.
Authors: A. B. Gutman
Journal: Annals of Internal Medicine (1962)

s1 April 1962Secondary Gout.A. B. Gutman, M.D., F.A.C.P., T. F. Yu, M.D.A. B. Gutman, M.D., F.A.C.P.Search for more papers by this author, T. F. Yu, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-675_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOrdinarily a genetically transmitted primary disease, gout occasionally is acquired, as a complication particularly of chronic hemopoietic disorders in which there is augmented turnover of nucleic acids and excessive formation of uric acid. Of 27 such cases encountered and classified as secondary gout in the past ten years, 22 developed in the course of polycythemia vera, myeloid metaplasia, or both. The ensuing clinical picture of acute arthritis responsive to colchicine and tophaceous deposits closely resembles primary gout, but there are some differences. A familial history of gout was obtained in only one case. Onset of overt gout occurred late in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. B. Gutman, M.D., F.A.C.P.; T. F. Yu, M.D.Affiliations: New York, N. Y. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGoutUric Acid CalculiThe Epidemiology of Hyperuricemia and GoutThe Etiology and Pathogenesis of Gout 1 April 1962Volume 56, Issue 4Page: 675-675KeywordsArthritisColchicineGenetic diseasesGoutNucleic acidsPolycythemia veraUric acid ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...
Herman's Difficult Labour. A Guide for Students and Practitioners.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proposed 1992 Budget Would Cut Graduate Medical Education Funding
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone Chip Plastic Reconstruction of Congenital Chest Deformities
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1811: The long noncoding RNA KIAA0125 is aberrantly expressed in ameloblastomas
Authors: Silvia F. Sousa, Marina G. Diniz, Josiane A. França, Fabricio A. Vilas-Boas, Fabricio T. Souza, George A. Calin, Ricardo S. Gomez, Carolina C. Gomes
Journal: Cancer Research (2019)

Abstract Long noncoding RNAs (lncRNAs) are transcribed RNA molecules that can interact with DNA or RNA, transcription factors, histones and other chromatin modifying proteins, affecting the expression level of a broad spectrum of genes. Because of their tissue-specific expression characteristics, lncRNAs hold strong promise as novel biomarkers and therapeutic targets for diseases. High-density whole-genome microarray analysis in ameloblastomas, an aggressive odontogenic tumor, and in adenomatoid odontogenic tumor (AOT), an indolent one, showed a high frequency of copy number alteration at chromosome band 14q32.33, which encompasses the lncRNA gene KIAA0125. To understand molecular mechanisms associated with their biological behavior and considering the copy-number gains observed at 14q32.33, we aimed to investigate the expression levels of the lncRNA KIAA0125 in ameloblastomas and in AOTs. The University Ethics Committee approved this study and patients signed informed consent. Thirteen frozen samples were included: five solid/multicystic ameloblastomas, four AOT, and four dental follicles. qPCR reactions were performed in triplicates and the relative changes in gene expression were obtained using the 2^-ΔΔCt formula. The reference gene HPRT1 was used for normalization and the human keratinocyte HaCat cell line was used as calibrator. Differences in the relative changes in gene expression between two groups of samples were assessed and the significance level was set at 0.05. All samples expressed more KIAA0125 than the calibrator. The ameloblastoma group showed higher expression levels of KIAA0125 when compared to dental follicles (p=0.042), while there was no difference between the expression in ameloblastomas and AOT (p&amp;gt;0.05). The expression levels of KIAA0125 in AOT were not different from that of the dental follicle. Our findings suggest that lncRNA KIAA0125 is likely involved in ameloblastoma pathobiology. LncRNAs hold strong promise as therapeutic targets, and experimental validation of this lncRNA functions may lead to tailored therapies targeting KIAA0125 in extensive and recurrent ameloblastomas. Citation Format: Silvia F. Sousa, Marina G. Diniz, Josiane A. França, Fabricio A. Vilas-Boas, Fabricio T. Souza, George A. Calin, Ricardo S. Gomez, Carolina C. Gomes. The long noncoding RNA KIAA0125 is aberrantly expressed in ameloblastomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1811.
Upjohn sues for libel
Journal: BMJ (1992)

for other sufferers, has undergone two un-I ll e that we're claiming all children's IQs go up, successftl attempts in London hospitals to g but it says clearly on the package inserts that wean her off steroids.Some claimants, who for vitam ns ma it's those with poor nutrition.Even one of include people in their 30s and 40s who were Y their experts is saying some children could treated with steroids as children, have gone breach Trade improve.It has already cost me £30000 and blind, and others have had to have hip will probably cost me £100000."He said that replacements.
Child Passenger Deaths Involving Drinking Drivers—United States, 1997-2002
Journal: JAMA (2004)

Motor-vehicle crashes are the leading cause of death among children aged >/=1 year in the United States, and one in four crash-related deaths among child passengers aged </=14 years involves alcohol use. To characterize the occurrence of child passenger deaths involving drinking drivers during 1997-2002, CDC analyzed data from the Fatality Analysis Reporting System (FARS) of the National Highway Traffic Safety Administration. This report summarizes the results of that analysis, which indicated that among the 2,355 children who died in alcohol-related crashes, 1,588 (68%) were riding with drinking drivers; the majority of these children were not restrained. To reduce the number of child fatalities in alcohol-related motor-vehicle crashes, effective interventions are needed to prevent alcohol-impaired driving and to increase use of child passenger restraints.
An English Handbook of the Paris Medical School.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal