tbuckley/cabot-search huggingface dataset:
CYTO-INHIBITION OF SERUM THERAPY
Journal: JAMA (1934)

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FIREPROOF STAIRS FOR HOSPITALS AND FACTORIES.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
REST.
Authors: C. F. ULRICH
Journal: JAMA (1897)

Rest is the restorer of lost power. Motion is the result of force exerted upon matter, and so long as the force continues to be applied and there are no impediments, the motion will continue. But to the motion of terrestrial bodies impediments always exist, and however much the motion may be stimulated by the renewed application of force, it will be retarded, and will ultimately cease. As an illustration, let us consider an engine run by water power, steam or electricity. As long as the power is applied, the engine runs, for a while, smoothly and with ease. Soon interruptions occur; there is a jar, and a hitch in the action. If this is not looked into and remedied, the machinery begins to run irregularly and something gives way. It either stops altogether, or its action becomes inefficient and the product of its labor useless. One of the most
Mortality and Cancer Rates among Workers in the Swedish PVC Processing Industry
Authors: Gustavo Molina, Bo Holmberg, Stig Elofsson, Lars Holmlund, Rein Moosing, Peter Westerholm
Journal: Environmental Health Perspectives (1981)

Personnel lists from four PVC-processing industries were collected on production of employees with at least three months of employment at the beginning of 1945 and the last day of employment December 31, 1974. Of 2073 persons, 103 could not be followed up, because they had moved abroad. The remaining persons comprise the cohort of 1970 individuals who were analyzed and compared with the national population with respect to mortality from various diseases and cancer morbidity. The death risk from myocardial infarction is elevated in the cohort. This elevation is most clearly apparent in the subcohort which had at least two years of exposure time and where the analysis was directed at circumstances chronologically close to the time of exposure. The myocardial infarction risk related to vinyl chloride exposure is discussed in relation to earlier studies on the vascular effects of vinyl chloride. An indication of an elevated risk of morbidity and mortality from tumors in the digestive organs is also present. However, this is not statistically confirmed. A few future follow-ups of the present study are necessary in order to clarify any possible elevated risk of tumors in the PVC-processing industry.
Reference Directories
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author index
Authors: Ackerman Mn, Adinoff Hollister, Abst Adinoff, Adkinson Nf, Alexander If, Aifansrnith Mr, Anderson Ja, Anderson Sd, Anderson Wh, Baird Rs, Baddo Ba, Feldman Ch, Fields Das, Findlay Sr, Fink Jn, Fitch Kd, J Foreman, Frey Mj, Friedhoff Lr, Friedman Ra, Frith Em, Furukawa Ct, F Gallagher, Garaci Cr, Del Gobbo, Jaffe Bm, Gauerke Mb, Gleich Gj, W Gold, Goldstein De, ( Goodwin, Greenberger Pa, Greenberger Patterson, K Kagey-Sobotka, Kaplan Ap, Katz Rm, Kauffman Hf, Kay Ab, Kemp As, Kemp Jp, Kern Eb, Abst Keyser, Monchy Jgr, J Van Doormal, Vader Van Voorst, Khan Ha, Klemawesch Sj, Koenig Jq, Kohler Pf, Kominsky Jr, Kopp De, Abst Koren, Krzanowski Jj, Kwiterovich Ka, L Laforce, Landenslager Ml, Ryan Sm, Drugan Rc, Hyson Rl, Maier Sf, Abst Langeland, Abst Laufer, Lee Th, Leff Ar, Lehrer Sb, Levy Da, Lewis Fh, Beals Tf, Mathews Kp, Abst Lewiston, Abst Lichtenstein, Liechty Rd, Firminger Hi, Abst Lindstrom, Liss Gm, Lackey Rf, Lopez Lr, L6pez Ri, Lumry Wr, Lynch Nr, M Mcfadden, E Jr, Mcmichael Gotch, Noble Beare, Mahan Lk, Malo Jl, Malveaux Fj, Mardiney 94 Marom, Martin Df, Martin Rr, Mathison Da, May Cd, Fornon Sj, Abst Medouze, Mekori Ya, Mellis Cm, Meltzer Eo, Mendelson Lm, Metcalfe Dd, Meyers Da, Michel F-B, Mickey Gh, Mingo Ts, Modlin Rl, Meyer Pr, Hofman Fm, Levy Nb, Lukes Rj, Parker Jw, Ammamt Aj, Conant Ma, Rea Th, Taylor Cr, Nadel Ja, Nair Nm, T Jp, Tonne1 Ab, Townley Rg, Unger Gf, V Valentine, Vanarsdel Pp, Van Asperen, Weller Pf, Whitehurst Ve, Butcher Bt, Butler Je, Butterfield I79, Cheuog N-K V, Chiaramonte Lt
Journal: Journal of Allergy and Clinical Immunology (1984)
EARMARK
Authors: Bradford Cannon
Journal: JAMA (1966)

The familiar word "earmark" derives its origin from the practice of notching, clipping, or perforating the ears of sheep or cattle for purposes of identification. In the great western ranges of the United States, such a conspicuous mark was important for quick identification because the animal instinctively turned toward the horseman, obscuring the brand on the flank. Man, alone among the animals, is the only one unwilling to leave his body as nature made it. In the tropics, where a minimum of clothing is worn, he scarifies or tattoos his skin. Where protected by clothing, the exposed head and face are decorated. Each tribe or civilization has had its peculiar devices for ornamentation. They include stone, bone, ivory, teeth, feathers, metals, plastics, ceramics, wood, seeds, and shells. They may be for adornment only or have symbolic meaning. They may be a mark of distinction or prestige. The Abadis women of
Spermidine acetyltransferase in rat hepatocytes cultured at different oxygen tensions
Authors: C Vargiu
Journal: Hepatology (1996)

To understand the mechanism involved in the liver zonation of polyamines, we have studied the possible role of oxygen tension. When hepatocytes were cultured at 21% and at 5% oxygen in atmosphere to mimic periportal and perivenous conditions, polyamine content was modified. The observed modifications suggested an effect on the interconversion pathway. Spermidine acetyltransferase (SAT) activity and N1-acetylspermidine were therefore measured in the same conditions. SAT activity was markedly increased after 6 hours and N1-acetylspermidine was accumulated in the cells. This was caused by new enzyme synthesis. The higher expression of SAT was accompanied by an increase in the content of the specific messenger RNA (mRNA). When liver cells were depleted of polyamines, SAT activity and the specific mRNA content were not enhanced by oxygen deprivation, but they increased when polyamines were added again. Polyamines therefore appear to be necessary to promote the increase in SAT mRNA.
Professional Loyalty.
Authors: O. N. Schudde
Journal: JAMA (1906)

Sullivan, Mo., Nov. 17, 1906. <h3>To the Editor:</h3> —About six months ago Dr. J. P. Dunigan of this place was sued for $30,000 damages for alleged failure to replace a dislocated hip. Trial was postponed once, and last week plaintiff took change of venue to Steelville, where the case will be called probably next month. Every physician in the county, including those subpoenaed by plaintiff, was on the side of the defendant, which caused the following remark from plaintiff's lawyer: This is the first and only place we have ever seen or heard of where all the doctors "stick" together. [The progress of organization in this country is having excellent results in the elimination of jealousy and strife among physicians, and the above is only one example of this fact. Often in the past it has been common for a physician to testify against another, against whom a malpractice suit
Contents
Authors: Geoff- Dusheiko Wedemeyer, Sauerbruch Tilman, Garcia-Tsao Guadalupe, C Thoens, C Berger, M Trippler, H Siemann, M Lutterbeck, R Broering, J Schlaak, F Heinemann, A Heinold, J Nattermann, N Scherbaum, G Alter, J Timm, R Maan, A Van Der Meer, B Hansen, J Feld, H Wedemeyer, J.-F Dufour, H Zangneh, F Lammert, M Manns, S Zeuzem, H Janssen, R De Knegt, B Veldt, T Inuzuka, Y Ueda, H Morimura, Y Fujii, M Umeda, T Kou, Y Osaki, S Uemoto, T Chiba, H Marusawa, A.-J Greenup, P Tan, V Nguyen, A Glass, S Davison, U Chatterjee, S Holdaway, D Samarasinghe, K Jackson, S Locarnini, M Levy, J Burton, J O'leary, E Verna, V Saxena, J Dodge, R Stravitz, J Levitsky, J Trotter, G Everson, R Brown, N Terrault, C.-H Chen, S.-N Lu, C.-H Hung, J.-H Wang, T.-H Hu, C.-S Changchien, C.-M Lee, F Macaluso, M Maida, C Camma, G Cabibbo, D Cabibi, R Alduino, V Di, A Craxı, S Petta, R Harris, B Thomas, J Griffiths, A Costella, R Chapman, M Ramsay, D De Angelis, H Harris, B Martin, N Hennecke, V Lohmann, A Kayser, C Neumann-Haefelin, G Kukolj, W.-O Bo, R Thimme, T Horvatits, A Drolz, K Roedl, H Herkner, A Ferlitsch, T Perkmann, C Mu, M Trauner, P Schenk, V Fuhrmann, C Cassinotto, B Lapuyade, A Mouries, J.-B Hiriart, J Vergniol, D Gaye, C Castain, B Le Bail, F Chermak, J Foucher, F Laurent, M Montaudon, V De Ledinghen, J Wakim-Fleming, M Pagadala, A Mccullough, R Lopez, A Bennett, D Barnes, W Carey, M Cortes, E Pareja, J Garcı ´a-Can, M Donato, S Montero, J Mir, J Castell, A Lahoz, G.-W Song, S.-G Lee, S Hwang, K.-H Kim, C.-S Ahn, D.-B Moon, T.-Y Ha, D.-H Jung, G.-C Park, S.-H Kang, B.-H Jung, Y.-I Yoon, N Kim, T Kokudo, K Hasegawa, S Yamamoto, J Shindoh, N Takemura, T Aoki, Y Sakamoto, M Makuuchi, Y Sugawara, N Kokudo, D Fuks, F Cauchy, G Fusco, V Paradis, F Durand, J Belghiti, A Carambia, B Freund, D Schwinge, M Heine, A Laschtowitz, S Huber, D Wraith, T Korn, C Schramm, A Lohse, J Heeren, J Herkel, K Scho ¨lzel, F Schildberg, M Welz, C Bo, S Geiger, C Kurts, M Heikenwa ¨lder, P Knolle, D Wohlleber, C Breuker, C Planque, F Rajabi, J.-C Nault, G Couchy, J Zucman-Rossi, A Evrard, J Kantar, E Chevet, P Bioulac-Sage, J Ramos, E Assenat, D Joubert, J Pannequin, F Hollande, J Pascussi
Journal: Journal of Hepatology (2014)
Human values and the medical curriculum. An educator's response
Authors: E. D. Pellegrino
Journal: JAMA (1969)

<h3>The Student Challenge</h3> Our students this morning have cogently and feelingly detailed a damaging case against contemporary medical education and practice. They have also literally pleaded for us, their older colleagues, to listen to this case. Their sincerity and their urgency demand not only that we listen, but that we<i>hear</i>and that we<i>respond</i>responsibly and with a concern at least equal to theirs. It is my delicate task to attempt such a response. I speak as one member of the educational establishment who shares their interest in change, relevance, and the primacy of human values in medicine. I must, however, underline the personal nature of this response. I disclaim any role as an official representative, but I hope some of my thoughts are representative of those entertained by other concerned educators and practitioners. The students have used commendable clarity and brevity to detail the deficiencies in human values
Die Bedeutung der Verschiedenartigen Strahlen für die Diagnose und Behandlung der Tuberkulose.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Essentials of Diseases of the Skin
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histology and outcome in localized high-risk soft tissue sarcomas (STS) treated with preoperative chemotherapy (CHT) with or without radiation therapy (RT) within a phase III trial from the Italian Sarcoma Group (ISG) and the Spanish Sarcoma Group (GEIS).
Authors: P. G. Casali, S. Stacchiotti, P. Verderio, P. Collini, A. P. Dei Tos, M. Alberghini, A. Llombart-Bosch, C. Morosi, A. Messina, M. Mercuri, A. Gronchi
Journal: Journal of Clinical Oncology (2011)

10089 Background: We reported on a phase III trial comparing 3 versus 5 cycles of preoperative CHT in high-grade localized STS of the extremities and trunk wall. We explored to which extent histological subtype was prognostically relevant in such an adjuvant series. Methods: 311 pts were eligible. All received 3 cycles of preoperative Epirubicin + Ifosfamide, followed by surgery. Local RT was administered before or after surgery. 136 pts were randomized to receive 2 more cycles of adjuvant CHT. In 222 (71%) cases, centralized pathological review was performed. Histology was categorized into 4 groups: MFH/undifferentiated pleomorphic sarcoma and spindle cell sarcoma NOS (Group 1 = 125 pts), leiomyosarcoma (Group 2 = 41 pts), synovial sarcoma (Group 3 = 68 pts), other (Group 4 = 77 pts). The influence of histology OS and RFS was retrospectively assessed through a univariate Cox regression model. Besides, responses to the preoperative treatment according to RECIST (78% evaluated pts of those with measurable disease) and CHOI criteria (50% evaluated pts) were retrospectively recorded. Results: Group 1, Group 2 and Group 3 accounted for about 75% of cases. At a median follow-up of 60 months (range = 24-102), the OS probability was 0.76, 0.48, 0.64 and 0.73, and the RFS probability was 0.61, 0.48, 0.59 and 0.65, respectively, for Groups 1, 2, 3, 4. For both OS and RFS, a trend in favour of a better outcome was observed in Group 1. On the contrary, a diagnosis of leiomyosarcoma correlated with both a worse OS (Group 1 vs Group 2: HR 2.88, 95%CI 1.63 – 5.01) and a worse RFS (Group 2 vs Group 1: HR 1.72, 95%CI 1.03-2.88). Leiomyosarcoma was marked by the highest number of PD according to both RECIST and CHOI criteria, and Group 1 had the highest RR, when changes in tumor density were accounted for with CHOI criteria. Conclusions: In this series of localized high-risk limb and trunk wall STS, leiomyosarcoma performed worse than the other types. This may be the product of the combination of natural history and chemosensitivity. At least in part, the latter may correlate with the outcome.
Observational study to evaluate the possible association between serum levels of C-reactive protein and response to the treatment of chemotherapy-induced anemia in solid tumors: Pronost study.
Authors: G. Esquerdo, J. M. Cervera, E. Barrajon, A. Juarez, C. Llorca, N. Diaz, A. Lopez, R. Peiro, L. Diez
Journal: Journal of Clinical Oncology (2011)

e19714 Background: The EORTC (European Organisation for Research and Treatment of Cancer) recommends that, in cancer patients receiving chemotherapy (CT) or CT +radiotherapy, treatment with erythropoietic agents should be initiated at a hemoglobin (Hb) level of 9-11 g/dL based on anemia-related symptoms. Likewise, EORTC recommends further studies on predictive factors that could anticipate response. Among possible response predictors, C-reactive protein (CRP) is mentioned. Primary study objective was to determine the correlation between CRP level and response to CT-induced anemia treatment in cancer patients. Methods: This is a prospective observational study of patients ≥18 years with solid tumours who developed CT-induced anemia. Response to anemia therapy and CRP levels at baseline, and weeks 6, 9, 12 and 16 of treatment were registered. Tests for normality and correlation were performed. Results: A total of 98 patients with solid tumours were included. Median age was 62.5 years, 64% were male, 57% had ECOG 0-1, 84% had III-IV stage cancer. Lung (31.6%), gastrointestinal (27.6%) and genitourinary (25.5%) were the most common tumour types. At study initiation, 63.8% had mild anemia (9.5 g/dL≤Hb≤10.9 g/dL, WHO definition), 21.3% had moderate anemia (8 g/dL≤Hb≤9.4 g/dL, WHO definition) and median CRP was 16.4 (Q1:3.9–Q3:76.7) mg/L. At weeks 6, 9, and 12 after treatment initiation, median Hb levels were 10.8 (Q1:10.1–Q3:11.9) g/dL, 11.2 (Q1:10.1–Q3:12.5) g/dL and 11.4 (Q1:10.3–Q3:11.9) g/dL. Median CRP level registered at same time-endpoints was 10.1 (Q1:2.1–Q3:46.3) mg/L, 9.6 (Q1:2.4–Q3:39.3) mg/L and 9.1(Q1:4.3–Q3:14.0) mg/L. During overall study, 68.35% of patients had a response to anemia-therapy defined as Hb >11 g/dL in absence of transfusions, which showed a weak correlation with CRP at baseline (rs = -0.3, p<0.05). At week 16 after treatment initiation, there were few patients for analysis of Hb and CRP. Conclusions: Baseline CRP is a possible predictive factor for response to treatment of chemotherapy-induced anemia in patients with solid tumors. This study was supported by AMGEN S.A.
PHYSICAL FITNESS
Authors: ERNST JOKL
Journal: JAMA (1941)

Kessler<sup>1</sup>has drawn attention to the importance of attaining clarity with regard to the objectives of physical fitness. In fact, few basic medical terms are equally vaguely defined and similarly loosely used. Of the many aspects of fitness, we intend to deal in this paper with only one: that of physical efficiency. The fundamental importance of this problem has not yet been fully recognized by the medical profession. It is insufficiently realized that the standard of physical efficiency dictates largely the rate of industrial and agricultural production, that it is one of the primary determinants of military preparedness, that it has a bearing on the health of the nation and that it influences the rate of progress of education. One of the main reasons for the difficulty of giving a clear definition of the term physical efficiency is lack of quantitative information on the subject. In his "Theory of