WERNER'S SYNDROME (PROGERIA OF THE ADULT) AND ROTHMUND'S SYNDROME: TWO TYPES OF CLOSELY RELATED HEREDOFAMILIAL ATROPHIC DERMATOSES WITH JUVENILE CATARACTS AND ENDOCRINE FEATURES; A CRITICAL STUDY WITH FIVE NEW CASES
Authors: S. J.  THANNHAUSER
Journal: Annals of Internal Medicine (1945)

Article1 October 1945WERNER'S SYNDROME (PROGERIA OF THE ADULT) AND ROTHMUND'S SYNDROME: TWO TYPES OF CLOSELY RELATED HEREDOFAMILIAL ATROPHIC DERMATOSES WITH JUVENILE CATARACTS AND ENDOCRINE FEATURES; A CRITICAL STUDY WITH FIVE NEW CASESS. J. THANNHAUSERS. J. THANNHAUSERAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-4-559 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptObservations on these rare and apparently heredofamilial disorders are scattered throughout the different branches of medical literature according to the particular interest of the individual author specializing in involvement of the eye or the skin or the nervous system.B. S. Oppenheimer and V. S. Kugel (1934) have the distinction of first reporting this condition in American medical literature, renaming it "Werner's syndrome." The characteristics of this syndrome are:Shortness of stature, characteristic habitusCanities (i.e., premature graying of the hair)Premature baldnessScleropoikilodermaTrophic ulcers of the legsJuvenile cataractsHypogonadismTendency to diabetesCalcification of the blood vessels...Bibliography I II III1. WERNER CW: Über Katarakt in Verbindung mit Sclerodermie, Inaug. Dissert., Kiel, 1904. Google Scholar2. VOSSIUS A: Zwei Fälle von Katarakt in Verbindung mit Schlerodermie, Ztschr. f. Augenh., 1920, xliii, 640. Google Scholar3. GUILLAINALAJOUANINEMARQUEZY GTR: Sclerodermie progressive avec cataracte double précoce chez un infantile, Bull. et mém. Soc. méd. d. hôp. de Paris, 1923, xxxix, 1489. Google Scholar4. MANJUKOWA N: Zur Frage über den Zusammenhang der Linsentrübungen mit Störungen der inneren Sekretion, Ruski Ophth. Jour. 2, Klin. Monatsbl. f. Augenh., 1923, lxx, 785. Google Scholar5. PAPASTRATIYAKIS C: Un nouveau syndrome dystrophique juvenile, Paris méd., 1922, xlv, 475. 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THANNHAUSER SJ: Hereditary ectodermal dysplasia of the anhydrotic and hydrotic types, Practitioner: Library of Med. and Surg., 1938, Appleton-Century Co., New York, xiii, 473. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 26, 1944.From the Joseph H. Pratt Diagnostic Hospital and Tufts College Medical School, Boston, Mass. Aided by grants from the Rockefeller Foundation and the Godfrey Hyams Trust Fund. 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