tbuckley/cabot-search huggingface dataset:
Central Processing
Authors: CaraBeth Lee
Journal: Annals of Internal Medicine (2019)

On Being a Patient4 June 2019Central ProcessingCaraBeth Lee, MDCaraBeth Lee, MDSwedish Medical Center, Seattle, Washington (C.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-2339 Audio Reading - “Central Processing” Audio. Virginia Hood, MD, reads “Central Processing” by CaraBeth Lee, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “Should we try the key? I think we should try the key,” my dad insists.I've flown the longest possible distance across the continental states, from Seattle to Florida, to be with my parents where they wait out the Midwest winter. My dad is fixated on the faulty glove compartment in the new car my mom leased yesterday. It refuses to budge when you push the button but pops open at random when you're driving down the road.He stands in the doorway of my room with his arm extended, pressing the fob toward me. “I can't find the key. ... Author, Article, and Disclosure InformationAffiliations: Swedish Medical Center, Seattle, Washington (C.L.)Corresponding Author: CaraBeth Lee, MD, Swedish Medical Center, 600 Broadway, Suite 340, Seattle, WA 98122; e-mail, carabeth.[email protected]org. PreviousarticleNextarticle Advertisement Audio Reading - “Central Processing” Audio. Virginia Hood, MD, reads “Central Processing” by CaraBeth Lee, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 4 June 2019Volume 170, Issue 11Page: 811KeywordsAdolescentsArmed forcesEmotionsMemorySurgeons ePublished: 4 June 2019 Issue Published: 4 June 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Immunology
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Marriage
Authors: Martin Kohn
Journal: Annals of Internal Medicine (1996)

Ad Libitum15 December 1996Medical MarriageMartin Kohn, PhDMartin Kohn, PhDRootstown, OH 44272.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-12-199612150-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Since she had always dreamtof making love on a beachand he was dreaming of furrowed fieldsthey figured it was timeAnd as soon as the youngest fell offto his nest below their bedand the events of the day haddrifted to the corners of the roomthey took the deeply plantedsigns to be what they meant to beand embracedLater, after two more phone callsthey marvelled at their jerry-built livesat the Rubegoldbergian blueprintthey swore once again to reviseand sang the praises of soundly sleeping childrenanswering machines and other small giftsonly God could have devised Author, Article, and Disclosure InformationAffiliations: Rootstown, OH 44272.Corresponding Author: Martin Kohn, PhD, Human Values in Medicine Program, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272-0095. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1996Volume 125, Issue 12Page: 954KeywordsChildren ePublished: 15 August 2000 Issue Published: 15 December 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PLASMA MAGNESIUM
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Retrospective Analysis on Prognostic Factors of Angioimmunoblastic T-Cell Lymphoma: a Multicenter Cooperative Study In Japan
Authors: Takashi Tokunaga, Kazuyuki Shimada, Kazuhito Yamamoto, Dai Chihara, Takuji Ichihashi, Rika Oshima, Mitsune Tanimoto, Toshihiro Iwasaki, Atsushi Isoda, Akira Sakai, Hikaru Kobayashi, Kunio Kitamura, Kosei Matsue, Masafumi Taniwaki, Sadahiro Tamashima, Yoshio Saburi, Taro Masunari, Tomoki Naoe, Shigeo Nakamura, Tomohiro Kinoshita
Journal: Blood (2010)
Accumulated Body Burden and Endogenous Release of Lead in Employees of a Lead Smelter
Authors: David E. B. Fleming, Denise Boulay, Norbert S. Richard, Jean-Paul Robin, Chris L. Gordon, Colin E. Webber, David R. Chettle
Journal: Environmental Health Perspectives (1997)

Bone lead levels for 367 active and 14 retired lead smelter workers were measured in vivo by X-ray fluorescence in May-June 1994. The bone sites of study were the tibia and calcaneus; magnitudes of concentration were used to gauge lead body burden. Whole blood lead readings from the workers generated a cumulative blood lead index (CBLI) that approximated the level of lead exposure over time. Blood lead values for 204 of the 381 workers were gathered from workers returning from a 10-month work interruption that ended in 1991; their blood level values were compared to their tibia and calcaneus lead levels. The resulting relations allowed constraints to be placed on the endogenous release of lead from bone in smelter works. Calcaneus lead levels were found to correlate strongly with those for tibia lead, and in a manner consistent with observations from other lead industry workers. Relations between bone lead concentration and CBLI demonstrated a distinctly nonlinear appearance. When the active population was divided by date of hire, a significant difference in the bone lead-CBLI slope emerged. After a correction to include the component of CBLI existing before the workers' employment at the smelter was made, this difference persisted. This implies that the transfer of lead from blood to bone in the workers has changed over time, possibly as a consequence of varying exposure conditions.
When wild ideas make sense.
Journal: BMJ (1979)

division of the musculomembraneous septum between the pouch behind and the oesophagus in front.13These con- siderations heavily favour primary excision as the treatment of choice, but whether excision should be combined with cricopharyngeal myotomy to deal with the underlying disorder is less certain.After excision alone the pouch recurs in 15% of patients,'4 and recurrence is more likely in those with associated gastro-oesophageal reflux and hiatus hernia.'5Whether myotomy is justifiable in these patients and whether it would reduce the recurrence rate remain matters for conjecture.
LITIGATION SYMPTOMS AND DISEASES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Embolism
Authors: A. J. Partridge
Journal: BMJ (1952)

<h3>BACKGROUND AND PURPOSE:</h3> Thrombus characteristics identified on non-contrast CT (NCCT) are potentially associated with recanalization with intravenous (IV) alteplase in patients with acute ischemic stroke (AIS). Our aim was to determine the best radiomics-based features of thrombus on NCCT and CT angiography associated with recanalization with IV alteplase in AIS patients and proximal intracranial thrombi. <h3>MATERIALS AND METHODS:</h3> With a nested case-control design, 67 patients with ICA/M1 MCA segment thrombus treated with IV alteplase were included in this analysis. Three hundred twenty-six radiomics features were extracted from each thrombus on both NCCT and CTA images. Linear discriminative analysis was applied to select features most strongly associated with early recanalization with IV alteplase. These features were then used to train a linear support vector machine classifier. Ten times 5-fold cross-validation was used to evaluate the accuracy of the trained classifier and the stability of the selected features. <h3>RESULTS:</h3> Receiver operating characteristic curves showed that thrombus radiomics features are predictive of early recanalization with IV alteplase. The combination of radiomics features from NCCT, CTA, and radiomics changes is best associated with early recanalization with IV alteplase (area under the curve = 0.85) and was significantly better than any single feature such as thrombus length (<i>P</i> &lt; .001), volume (<i>P</i> &lt; .001), and permeability as measured by mean attenuation increase (<i>P</i> &lt; .001), maximum attenuation in CTA (<i>P</i> &lt; .001), maximum attenuation increase (<i>P</i> &lt; .001), and assessment of residual flow grade (<i>P</i> &lt; .001). <h3>CONCLUSIONS:</h3> Thrombus radiomics features derived from NCCT and CTA are more predictive of recanalization with IV alteplase in patients with acute ischemic stroke with proximal occlusion than previously known thrombus imaging features such as length, volume, and permeability.
First-line mTOR inhibition in metastatic renal cell carcinoma (mRCC): An analysis from the International mRCC Database Consortium.
Authors: Lauren Christine Harshman, Lori Wood, Sandy Srinivas, Daniel Yick Chin Heng, Toni K. Choueiri
Journal: Journal of Clinical Oncology (2013)

430 Background: mTOR inhibitors (mTORi) are an important class of targeted therapies for mRCC that may act through regulation of mTOR as well as hypoxia-inducible factor and its resultant downstream angiogenesis pathways. FDA approval was based on efficacy in poor risk patients in the first-line setting for temsirolimus (T) and in sunitinib- and sorafenib-refractory patients for everolimus (E). Little is known about T’s effectiveness in good and intermediate risk patients and E’s outcomes in the first-line setting. Methods: We evaluated our international mRCC database to evaluate the outcomes of patients who received mTORi as their first-line targeted therapy. Results: Of the 2,370 patients in the database, 49 received a first-line mTORi (7 E, 42 T). Median age was 61 years and median KPS was 80%. 63% had clear cell and 37% had non-clear cell histology. 65% had prior nephrectomy. Of the 38 patients with available Heng prognostic risk criteria, 21%, 21%, and 58% were good, intermediate, and poor risk respectively. Median PFS and OS are detailed below. Objective responses and disease stabilization were achieved in 5% and 58%. Second-line therapy was administered in 21 patients of which 17 received VEGF inhibitors. Conclusions: Outcomes for good and intermediate risk patients treated with first-line mTORi were lower than historically expected for patients treated with VEGF targeted therapies. These results may be due to inclusion of non-clear cell histologies, treatment biases, small sample size, or other undefined confounders that need further exploration. Greater data capture of this important cohort of patients to confirm these results is planned and will be presented. [Table: see text]
Cardiovascular and renal function of angiotensin II type-2 receptors
Authors: O JOHREN
Journal: Cardiovascular Research (2004)

While all of the well-known cardiovascular and renal effects of angiotensin II (ANG) are attributed to the ANG type-1 (AT1) receptor, much less is known about the function of ANG type-2 (AT2) receptors. This review focuses on progress made in AT2 receptor research over the past 10 years mainly enabled by the availability of AT2 receptor-deficient mice. Two general mechanisms regarding AT2 receptor-mediated actions emerge from recent experiments. Firstly, AT2 receptor stimulation inhibits growth and promotes apoptosis, an important mechanism during development and tissue remodeling. Secondly, ANG stimulates the release of nitric oxide (NO)/cGMP via AT2 receptor activation, as described in the aorta, heart, and kidney. This effect appears to be indirectly mediated by the modulation of bradykinin release. Thus, activation of AT2 receptors may be potentially protective and appears to oppose the effects mediated by AT1 receptors. The question whether AT2 receptors are activated in patients with elevated ANG levels when treated with AT1 receptor antagonists and whether these effects are relevant awaits further clarification.
Abstract 2942: Cathepsin S inhibition alleviates oxaliplatin-induced peripheral neuropathy through regulation of Ca2+ homeostasis
Authors: Szu-Jung Chen, Meng-Ru Shen, Li-Hsien Chen, Hsiao-Han Lin, Shih-Han Hsu, Jang-Yang Chang
Journal: Cancer Research (2019)

Abstract Chemotherapeutic drug oxaliplatin is frequently causing chemotherapy-induced peripheral neuropathy. Currently, there is no effective drug to prevent neuropathy in the clinic. Therefore, identification of the potential target to treat to alleviate oxaliplatin-induced neuropathy is urgent. Previously, the release of cathepsin S (CTSS) from microglial cells, which causes neuropathic pain, has been reported, but the detailed mechanism remains unclear. In this study, we discovered that oxaliplatin treatment triggers CTSS expression accompanies with prompted calcium influx from SOCE in vitro. And, the oxaliplatin treated mice displayed increased tail-withdrawal temperature hyperalgesia and impaired locomotor activity along with the loss of neuromuscular function. Furthermore, oxaliplatin-induced peripheral neuropathy was inhibited by the highly selective CTSS inhibitor, 58, which significantly improved the thermal sensitivity and alleviated mechanical allodynia on the heat tail-withdrawal and von Frey tests in oxaliplatin-treated mice, respectively. The grip strength test showed that 58 significantly improved the motor strength and neuromuscular function of oxaliplatin-treated mice. The ultrastructure of sciatic nerve myelin integrity through G ratio quantification supported the observations in our oxaliplatin-induced peripheral neuropathy mouse behavioral tests. Also, inhibition of CTSS enzymatic activity by 58 resulted in the suppression of STIM1 aggregation and decreasing the oxaliplatin-induced calcium influx from SOCE. These results revel a novel molecular mechanism of CTSS in the involvement of oxaliplatin-induced peripheral neuropathy. (This study was supported by the following grants: the National Health Research Institutes (CA-107-PP-22), the Ministry of Science and Technology (MOST 106-2314-B-006-076-MY3) Citation Format: Szu-Jung Chen, Meng-Ru Shen, Li-Hsien Chen, Hsiao-Han Lin, Shih-Han Hsu, Jang-Yang Chang. Cathepsin S inhibition alleviates oxaliplatin-induced peripheral neuropathy through regulation of Ca2+ homeostasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2942.
Recent Advances and Future Frontiers in Treating Age-Related Cataracts—Correction
Authors: David Vinkers, Jacobijn Gussekloo, Roos Van Der Mast, Frans Zitman, Rudi Westendorp
Journal: JAMA (2003)

assessed from computerized pharmacy registries.Use of benzodiazepines was observed in more than a quarter of the participants.During follow-up, use of benzodiazepines was not related to all-cause mortality.Similar to prior studies, however, we found an increase of mortality related to fracture in individuals who used benzodiazepines.The small number of deaths from fractures may explain the absence of statistical significance.The use of benzodiazepines is common in individuals aged 85 years or older, although benzodiazepines are indicated only for a limited number of psychiatric disorders.In practice, clinicians should weigh the risks and benefits of benzodiazepine use.However, we did not find an increased risk of mortality related to benzodiazepine use.
Reviewers for Ophthalmology and 1983 Editorial Board
Authors: Joseph Walsh, Mathea Allansmith, Ronald Burde, David Guyton, Donald Hall, Robert Stamper, Barbara Streeten, Ronald Carr, Frederick Jakobiec, Herbert Kaufman, Editorial Advisors, Jerome Bettman, Robert Drews, Richard Einaugler, Brenda Gallie, Richard Lewis, Robert Machemer, J Rowsey, Myron Anoff, Y Henkind-Managing Editor, Pam Ballinger-Production Editor, Joan Gullusci-, Patricia Shanahan, Albert Ackerman, Joan Albin, Lee Allen, Richard Anderson, Geoffrey Arden, Gilbert Baum, Jules Baum Crowell Beard, Bernard Becker, Hugh Beckman, Myles Behrens, Charles Belcher, Arthur Berger, Eliot Berson, Edwin Billet, Richard Binkhorst, Alan Bird, Frederick Blodi, Ivan Bodls-Wollner, Milton Boniuk, William Bourne, George Bresnick, Stuart Brown, Seymour Brownstein, Alston Callahan, H Dwight Cavanagh, Paul Chandler, Devron Char, Norman Charles, David Cogan, D Jackson Coleman, August Colenbrander, Robert Coles, Edward Cotlier, Brian Curtin, Robert Della Rocca, Kenneth Diddle, Claes Dohlman, Ralph Eagle, M Robert, Jaym Ellsworth, David Enoch, J Epstein, Ernest Terry, A Thomas, Eleanor Farrell, Jay Faye, Rick Federman, Daniel Ferris, Yale Finkelstein, Joseph Fisher, Robert Flanagan, John Flowers, Arnold Flynn, Richard Forrest, Frederick Forster, Anne Fraunfelder, J Fulton, Arthur Donald, Morton Gold, Richard Goldberg, Arthur Green, A Froncie, William Gutman, Sohan Ham, Eugene Ha Yreh, David Helveston, Kenneth Hiles, William Hoffer, Nicholas Hoyt, Norman Iliff, Geraint Jaffe, Robert James, Lee Jampel, Danny Jampol, Carolyn Jones, Thomas Kalsow, Arthur Kearns, John Keeney, Robert Keltner, Kenneth Kennedy, Kenn Kenyon, Steven Kostuk, Carl Kramer, Theodore Kupfer, Norman Wwill, Irving Leeds, Sidney Leopold, Harvey Lerman, Jay Lincoff, R Lippman, Hunter Lisman, Lois Little, Martin Lloyd, George Mainster, John Sheila Margolis, Samuel Marshall, Neil David Miller, Joel Miller, Thomas Mindel, A Robert, Charles Moses, Edward Naiman, Denis Norton, Edward O'da Y, Karl Okun, Marshall Ossoinig, Edward Parks Arnallpatz, Gholam Perkins, Irvin Peyman, Robert Pollack, James Priest, Allen Puklin, Robert Putterman, Robert Reinecke, Arthur Ritch, Melvin Rosenbaum, Stephen Rubin, Donald Aran Safir, Marvin Sanders, Robert Sears, Bruce Sergott, Jerry Shields, Koichi Shields, Bernd Shimizu, Richard Silver, Robert Simmons, Byron Small, David Smith, Alfred Soll, George Sommer, William Spaeth, Walter Spencer, Orkan Stark, Susan Stasior, H Stenson, Joel Saul Sugar, Alan Sugar, Frederick Susal, Richard Theodore, Stanley Thoft, Phillips Thompson, Ramesh Thygeson, Thi Tripa, L Stephen, Richard Trokel, Diane Troutman, Paul Vanhorn, Gunter Vinger, Thaddeus Vonnoorden, Frederick Wandel, Robert Wang, Daniel Watzke, Robert Weiss, Christian Welch, Jonathan Wertenbaker, James Wirtschafter, Thomas Wise, Robert Wood, Wright Woolson Barry, E Lorenz
Journal: Ophthalmology (1983)
Manuscripts Approved for JNCI, November–December 1973
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Manuscripts Approved for JNCI, November–December 1973 Get access JNCI: Journal of the National Cancer Institute, Volume 52, Issue 1, January 1974, Pages 310–312, https://doi.org/10.1093/jnci/52.1.310-a Published: 01 January 1974
&lt;TITLE&gt;Parkinson Disease&lt;/TITLE&gt;
Journal: JAMA (2000)

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