tbuckley/cabot-search huggingface dataset:
Combination of bevacizumab and chemotherapy in the first-line treatment of metastatic colorectal cancer: Slovakian experience.
Authors: T. Salek, M. Mego, J. Mardiak, I. Andrasina, S. Spanik, V. Malec, R. Barilla, K. Riedelova, A. Benedikty, A. Dammak, S. Porsok, V. Svabova, M. Chovanec, A. Cipkova, V. Usakova, M. Siskova, S. Jurisova, J. Dolinsky, Z. Hlavata, I. Andrezalova
Journal: Journal of Clinical Oncology (2011)

e14152 Background: Bevacizumab a recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine. Bevacizumab binds to VEGF and inhibits VEGF receptor binding, thereby preventing the growth and maintenance of tumor blood vessels. Here, we report efficacy and safety of combination of bevacizumab and chemotherapy in patients (pts) with metastatic colorectal cancer (mCRC) treated in Slovakia from 01/2008 to 07/2010. Methods: Five hundred ninety-two consecutive pts (33.2% F/66.8% M) with mCRC treated with irinotecan-based (78.2%), oxaliplatin-based (14.2%) and 5FU/LV (7.6%) chemotherapy were evaluated. Median age was 61 years (19-85). 197 pts were pretreated with adjuvant therapy. No of metastatic sites: 1 mts - (66.7%), 2 mts- (28.0%), 3 mts and more - (6.3%). Results: 44 pts achieved complete remission (7.6%) 222 pts partial remission (38.1%), 243 pts disease stabilization (41.8%), 73 pts disease progression (12.5%). 10 pts was not evaluable for response. Median progression free survival (mPFS) was 9 months (1-36). The main Gr 3-4 toxicity was diarrhea 35 pts (5.9%),VTE 28pts (4.7%), hypertension 24 pts (4.1%), leucopenia 19 pts (3.2%), haemorrhage 12 pts (2.0%) and neuropathy 9 pts (1.5%). Conclusions: Our experience confirms the efficacy and acceptable safety profile of combination chemotherapy and bevacizumab in first-line mCRC patients.
Chronic granulomatous disease of childhood in a 23-year-old man
Authors: H. H. Balfour
Journal: JAMA (1971)

A 23-year-old man with a history of recurrent bacterial and fungal infections since age 12 was shown to have a functional leukocyte defect similar to that found in children with chronic granulomatous disease. A liver biopsy revealed discrete granulomata. The documentation of this case calls attention to the possibility that there may be a mild form of chronic granulomatous disease and that recurrent bacterial infection in the adult may be due to a functional disorder of polymorphonuclear leukocytes.
Adh Locus in Maize for Detection of Mutagens in the Environment
Authors: Drew Schwartz
Journal: Environmental Health Perspectives (1981)

The advantages of the maize Adh system for low level mutagenesis studies are discussed. They include high mutation rate and the availability of both a strong selection system for null mutants and a sensitive method for detection of variants. The null selection involves treatment of pollen with allyl alcohol which is converted by the Adh enzyme to the toxic acrylaldehyde. Adh variants can be detected by alteration in affinity for phytic acid as well as thermal stability and electrophoretic mobility.
Smokeout could preface 'smoke-free society'
Authors: P. Gunby
Journal: JAMA (1984)

Now that the Eighth Annual Great American Smokeout is history, how many of those who—in the glare of news media attention—gave up smoking (at least temporarily) are still managing to refrain from lighting up? If experience from the previous seven Smokeouts is any guide, says the sponsoring American Cancer Society, something over 4% of those who gave up smoking for a day have still not resumed. The New York City-based American Cancer Society describes the Great American Smokeout—which this year was held on Nov 15—as "an upbeat, good natured effort to encourage smokers to give up cigarettes for 24 hours, if only to prove to themselves that they can." This year's goal was to convince "at least one in every five smokers to give up cigarettes from midnight to midnight on Nov 15." Last year, according to the society, "just under 36% of [an estimated 54 million] American smokers attempted
First International Symposium on the Modulation and Mediation of Cancer by Vitamins
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article First International Symposium on the Modulation and Mediation of Cancer by Vitamins Get access JNCI: Journal of the National Cancer Institute, Volume 67, Issue 4, October 1981, Page 957, https://doi.org/10.1093/jnci/67.4.957 Published: 01 October 1981
Bone density in amenorrheic athletes and in anorexia nervosa
Authors: P. S. Mehler
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The study by Rencken and colleagues<sup>1</sup>raises additional concerns about the detrimental effects of amennorhea in female athletes. Another population of young females for whom a similar concern is warranted includes those individuals who have anorexia nervosa. This disorder is characterized by abnormally low nutrient intake, refusal to maintain body weight at or above 85% of normal weight, intense fear of weight gain, and amenorrhea of at least 3 months' duration.<sup>2</sup>The prevalence of anorexia nervosa is 1% to 4% among adolescent females and college-age women and seems to be increasing; only about 50% of patients recover completely.<sup>3</sup> Osteoporosis recently has been added to the growing list of medical complications associated with anorexia nervosa. Pathologic fractures of the hip, spine, and long bones have been reported in these patients. These often occur early in the course of anorexia in adolescent girls, presumably because
Decline in mortality, AIDS, and hospital admissions in perinatally HIV-1 infected children in the United Kingdom and Ireland
Journal: BMJ (2004)

2][13] In particular there is confusion about whether revalidation is intended to detect poor performance, and if so, whether the process will suffice.Formative appraisal and summative revalidation are seen as uneasy bedfellows. 13 14 For most doctors the process will entail participation in an appraisal system, which must be aligned with the headings in Good Medical Practice and quality assured to the satisfaction of the General Medical Council. 15The Council states that such participation will be "a powerful indicator of a doctor's current fitness to practise," 1 but makes no claim that the process will be sensitive (identify poor performance), specific (identify educational needs), valid (reflect actual clinical practice), or reliable (behave consistently across cohorts of doctors). 16Where there is any doubt doctors will be invited to submit more information and may be subjected to the performance procedures.
Editorial: IUDs and heavy periods.
Journal: BMJ (1976)

The commonest side effect of IUD use is abnormal uterine bleeding. This symptom leads to removal of the device in 14% of users. With the newer copper-covered devices, the increase in bleeding is less. Endometritis has been observed but a discrepancy in the stage of endometrial development is more common in IUD users. Hormonal patterns remain normal, hence a systemic effect of the IUD is unlikely. Possible the IUD exerts its contraceptive effect after implantation has begun. The mechanism of this side effect may be related to the contraceptive action of the device.
Von Hippel-Lindau Disease and Pheochromocytoma-Reply
Authors: Charis Eng
Journal: JAMA (1996)

<h3>In Reply.</h3> —The findings of Drs Walther and Linehan are consistent with the findings in our article. These authors also call attention to another entity, namely, pheochromocytoma-only families. These families are different from the two reported in our article since both of our families have well-documented C-cell tumors, the hallmark of MEN-II. We suspect that the majority of pheochromocytoma-only families will turn out to have<i>VHL</i>mutations<sup>1</sup>and those without might be due to the as yet unidentified<i>PGL</i>locus on the long arm of chromosome 11.<sup>2</sup> Prior to the observations made by Walther and Linehan and those in the cited French study,<sup>3</sup>we reported a high incidence of VHL in patients with symptomatic pheochromocytoma and documented that 38% of VHL patients identified in our series had only pheochromocytoma even after intensive investigation.<sup>4</sup>
Attenuated Salmonella becomes versatile vector in multivalent, multipurpose genetic vaccines
Authors: B. Merz
Journal: JAMA (1987)

AN AVIRULENT<i>Salmonell</i>a strain is the basis of the first bacterial vaccine to generate a mucosal as well as cellular and humoral immune response. The vaccine is a genetically engineered form of<i>Salmonella typhi</i>that has been rendered avirulent by removal of the genes that code for two enzymes, adenylate cyclase and C-reactive protein, that are necessary to produce cyclic adenosine monophosphate (cAMP). Robbed of its ability to produce cAMP, the bacterium cannot metabolize sugars, transport amino acids, or synthesize cell-surface structures. It is carried to its customary habitat—the lymphoid cells of the gastrointestinal mucosa or Peyer's patches—where, lacking the capability (and the cilia) to go forth and multiply, it lives for five to seven days. The odds are heavily against the avirulent<i>Salmonella</i>'s reacquiring the ability to make cAMP by picking up a plasmid containing the gene from another gut-dwelling bacterium, says the vaccine's developer, Roy Curtiss
英国有多少人患有大疱性类天疱疮?
Journal: British Journal of Dermatology (2021)

大疱性类天疱疮是一种令人苦恼的疾病, 会导致皮肤出现水泡和瘙痒。这项在英国开展的研究旨在了解每年首次患大疱性类天疱疮的人数 (发病率) 、在任何给定时间点患大疱性类天疱疮的人数 (患病率) 以及大疱性类天疱疮患者的死亡率是否高于其他人 (死亡率) 。
Immunological Studies in Cattle Exposed to Polybrominated Biphenyls
Authors: John R. Kateley, S. J. Bazzell
Journal: Environmental Health Perspectives (1978)

The intactness of the immune system in cattle exposed to polybrominated biphenyls (PBBs) has been investigated by using several immunoassays. Eighty-seven animals have been studied, 35 control animals (not exposed to PBBs) and 52 animals exposed to PBBs (0.02–30 ppm/g fat equivalent). The immunoassays included a complete blood count, identification of peripheral blood T and B lymphocyte subpopulations, serum immunoglobulin levels (IgG, IgM, and IgA), the in vitro response to lymphocytes to phytolectins (PHA, Con A, PWM), the antibody response to Keyhole limpet hemocyanin (KLH), the cell-mediated response to PPD, and determination of autoantibodies and/or immunosuppressive serum factors. For control and PBB-exposed cattle, there was no statistical difference between the number of circulating erythrocytes or leukocytes, the hematocrit, or hemoglobin content; the percentage or number of T and B lymphocytes; the isotope incorporation index (DNA synthesis) of lymphocytes in response to mitogens; the concentrations of serum immunoglobulins IgG, IgM, or IgA; the mean peak titer to KLH; or in vivo or in vitro immune response to PPD. Additional evaluation of cattle with tissue levels of PBB greater than 3 ppm/g tissue for hematological and immunological parameters revealed no statistical difference from control animals. Other experiments were performed to evaluate serum from cattle exposed to PBBs for autoantibodies to smooth muscle, mitochondrial or nuclear antigens. No evidence for autoantibodies was observed. Further studies were done to examine the cytotoxic and/or immunosuppressive activity of sera from PBB-exposed animals. In these studies, the blastogenic response of lymphocytes from control cattle and humans were evaluated in the presence and absence of serum from animals exposed to PBBs (&gt; 3 ppm/g tissue). No evidence for either a cytotoxic or an immunosuppressive influence of such sera was demonstrable. Our studies indicate that PBB, at the levels studied, does not alter or interfere with lymphocyte surface antigens, the complex nuclear and cytoplasmic events required for mitosis and cell division, or the biological events required for antibody formation and cell-mediated immune reactions. Further, PBB exposure at the levels studied does not predispose cattle to autoantibody production or leucotoxic serum factors.
"In" Left Out
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pyemotes dermatitis caused by indirect contact with husk rice
Authors: T. Uenotsuchi, E. Satoh, H. Kiryu, Y. Yano
Journal: British Journal of Dermatology (2000)

Journal Article Pyemotes dermatitis caused by indirect contact with husk rice Get access T. Uenotsuchi, T. Uenotsuchi Department of Dermatology, Kyushu‐chuoh Central Hospital, Japan Search for other works by this author on: Oxford Academic Google Scholar E. Satoh, E. Satoh Department of Dermatology, Kyushu‐chuoh Central Hospital, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Kiryu, H. Kiryu Department of Dermatology, Faculty of Medicine, Fukuoka University, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Yano Y. Yano Department of Immunology and Parasitology, Fukui Medical University, Japan Correspondence: Takeshi Uenotsuchi, Department of Dermatology, Hiroshima Red Cross Hospital and Atomic‐Bomb Survivors Hospital, Hiroshima 730–8169, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 3, 1 September 2000, Pages 680–682, https://doi.org/10.1111/j.1365-2133.2000.03754.x Published: 01 September 2000
Marriages
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Iron supplementation after femoral head replacement for patients with normal iron stores
Authors: N. P. Zauber
Journal: JAMA (1992)

<h3>Objective.</h3> —To assess the efficacy of oral iron therapy in the recovery of patients' hemoglobin levels after major surgery. <h3>Design.</h3> —Randomized controlled trial. <h3>Setting.</h3> —Private orthopedic practice confined to one large community hospital. <h3>Patients.</h3> —One hundred seventy consecutive elderly patients undergoing hip surgery; 75 failed to meet entry hematologic or medical criteria; 95 were randomized, with 16 withdrawn because of complications. <h3>Intervention.</h3> —Thirty-seven patients received ferrous sulfate orally four times a day for the duration of their hospitalization. Forty-two patients who received no iron supplement served as the control group. <h3>Main Outcome Measures.</h3> —Changes in hemoglobin levels and reticulocyte counts over the 2- to 3-week follow-up period. <h3>Results.</h3> —There was no significant difference in mean hemoglobin levels between the treatment and control groups (95% confidence interval [Cl] for difference of —6.6 to 5.4 g/L). Corrected reticulocyte fractions increased equally in both groups (95% Cl for difference of —9 × 10<sup>3</sup>to 2 × 10<sup>-3</sup>. The study was designed to detect a difference in mean hemoglobin levels of 8.5 g/L or greater or a difference in mean reticulocyte fraction of 10 × 10<sup>-3</sup>between the two groups with a power of 0.80 at the .05 (two-sided) level of significance. <h3>Conclusion.</h3> —The administration of oral iron supplements to elderly, healthy orthopedic patients postoperatively did not hasten the recovery of hemoglobin levels, provided adequate tissue iron stores were present. (<i>JAMA</i>. 1992;267:525-527)
Wet work exposure and hand eczema among healthcare workers: a cross-sectional study
Authors: N. Hamnerius, C. Svedman, O. Bergendorff, J. Björk, M. Bruze, A. Pontén
Journal: British Journal of Dermatology (2018)

Hand eczema is common among healthcare workers. One reason is high exposure to soap and water. To prevent the spreading of infections more rigorous hygiene procedures have been implemented in healthcare during the last decade. The purpose of this study was to see how the use of disposable gloves, alcoholic hand disinfectants, and soap is associated with hand eczema. An electronic questionnaire was sent to all hospital employees in southern Sweden. Only the respondents working as nurses, assistant nurses and physicians were included in the analyses. In this group 21% had had hand eczema during the last 12 months, which is higher compared to the general population. 30% washed their hands with soap more than 20 times per day at work, 54% used non‐sterile disposable gloves for more than 2 hours per day, and 45% used alcoholic hand disinfectant more than 50 times per day. Hand eczema was more common among those who more often used soap, and among those who used disposable gloves for longer times. However hand eczema was not associated with the use of alcoholic disinfectants. This study shows that hand eczema still is common in healthcare workers. Educational programmes directed at prevention of hand eczema are needed.
The Lettsomian Lectures ON AMOEBIC LIVER ABSCESS: Delivered before the Medical Society of London
Authors: L. Rogers
Journal: BMJ (1922)

AMOEBIC LIVER ABSCESS.3 TH .ns45 and there was no discharge or hiistory of discharge of any kind.Tlle patient was seen witlh me by Dr. Macdonald, to whose help I am indebted; he agreed that the condition miglht be an osteoma.Operation.On September 30th, 1921, an iDcision was made alonig the right eyebrow down to the periosteum.The supraorbital ridge was then felt to terminate in a sharp irregular ridge.and in attempt- ing to separate the orbital periosteum a thick gelatinous substance the colour of very pale yolk of egg presented; this I swabbed and scooped away withl a blunt spoon; it measured, perhaps, a table- spoonful.There was apparently a delicate envelope, and pieces of eroded floor of the frontal sinus adlhered.After this removal none of the floor of the sinus rema ned.The cavity above was bounided by the roof of the sinus.Either there was no median raphe between the right and left sinuses or it had been eroded; an opening which would have admitted a pencil led to the left sinus.As the condition in the left sinus was obviously the same as the right, a further incision was made tlhrough the left eyebrow, the periosteum was reflected, snd thie floor of the sinus, wlhich was tliin and fragile, was chiselled through aud the sinus emptied.Both fronto-nasal ducts appeared to be occluded.Drainage was established by two thick gauze drains into the nose throngh open- ings made by a spoon in the position of both ducts.The incisions were sutured.The gauze drains were removed on the following day. After-IIistory.A little blood-stained discharge continued to flow from the right nostril for some days.Forty-eight hours after the operation I was called to the case, and in my absence Dr. Macdonald kindly saw the patient at about 10 p.m.He describes her condition as follows: " She was comatose, curled up in bed; could not be roused.. Temperature 1020.Did not respond to any stimulus.Reflexes normal."By midnight her conldition was improved in that she could be got to respond to vigorous stimulation, btut in the circumstances the condition was alarming, indicating a possible onset of meningitis.On careful examination Dr. Macdonald came to the conclusion there were indications pointing to the condition being at least partly hysterical, and that this was probably so is borne out by imme- diate anid uninterrupted improvemenit.
Reply
Authors: Sonali Paul
Journal: Hepatology (2017)

Potential conflict of interest: Nothing to report. We welcome the comments from Huang and Lee on our meta‐analysis of surface antibody in hepatitis B virus (HBV) reactivation. First, as mentioned in our Table 1 footnote, our definition of HBV reactivation incorporated the broad range of outcomes reported in the literature: detectable HBV DNA, HBV detection with or without conversion from hepatitis B surface antigen (HBsAg) negative to positive, HBV DNA >10 IU/mL, HBV DNA > 10‐fold increase versus previous nadir, or conversion from HBsAg‐negative to HBsAg‐positive.1 Their reported elevation of HBV viral load to >2,000 IU/mL from baseline2 satisfied our HBV detection criterion for reactivation. Second, we agree with Huang and Lee that the incidence of HBV reactivation occurs more frequently as a detectable HBV DNA level than as HBsAg reverse seroconversion in patients receiving rituximab therapy. In our meta‐analysis of patients receiving rituximab therapy, reactivation only occurred as detectable HBV DNA without any reported cases of HBsAg reverse seroconversion. Although Huang and Lee mention that we may have overlooked the risk of HBV reactivation in patients with hepatitis B surface antibody undergoing rituximab therapy, we did include that study3 in our meta‐analysis as citation 22. Additionally, our discussion specifically mentions that the presence of hepatitis B surface antibody reduces but does not eliminate the risk of HBV reactivation. Our meta‐analysis suggests that patients with hepatitis B surface antibody still have a 5.6% residual risk of reactivation, so we would recommend antiviral prophylaxis in these patients. Lastly, we agree that heterogeneity among studies is a potential limitation of any meta‐analysis. Grouping studies with concordant outcomes would have reduced the power to detect statistically significant results, with four studies using detectable HBV DNA, six studies using HBV detection with or without conversion from HBsAg negative to positive, two studies using HBV DNA >10 IU/mL, seven studies using HBV DNA >10‐fold increase versus previous nadir, and one study using conversion from HBsAg‐negative to HBsAg‐positive. Despite the differences in outcome measures, the I2 test for heterogeneity4 was 0% among all analyses, suggesting no inconsistency in the results across studies.