tbuckley/cabot-search huggingface dataset:
THE PERPETUATION OF THE SHEPPARD-TOWNER IDEA
Journal: JAMA (1926)

An immediate onslaught of Sheppard-Towner propagandists, to jam through Congress the pending bill<sup>1</sup>to extend the life of the Sheppard-Towner Act, may be expected when Congress convenes, December 6. As passed by the House of Representatives, this bill proposes to extend the act for two years. The Senate Committee on Education and Labor has recommended, however, that the extension be reduced to one year, and with that recommendation the bill is now on the Senate calendar. Its proponents will probably urge amendment on the floor of the Senate to provide for a two year extension, and its immediate enactment as thus amended. Unless the bill is promptly enacted, the thirty-nine legislatures that convene in January can hardly enact the reciprocal state legislation necessary to consummate the purchase by the federal government of the constitutional right of the states to control hygiene and sanitation within their own borders. When the Sheppard-Towner
THE PRESIDENT'S PLANS FOR ECONOMIC SECURITY
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Large trials vs meta-analysis of smaller trials
Authors: B. T. Johnson
Journal: JAMA (1997)

<h3>In Reply.</h3> —Dr Klebanoff and colleagues bring into focus the controversy of fixed vs random effects models of combining data.<sup>1</sup>We think it was fair and reasonable for us to report both effects and to point out that, when diversity is present, a random effects model is probably more appropriate. It is puzzling why these authors attribute to us an a priori belief that large trials usually support the results of meta-analyses of small trials. Their second concern is imprecise. We reported that a higher event rate was associated with a greater benefit of treatment in 4 cases (not 5 cases), but with a smaller benefit in 1 case. Klebanoff et al seem to believe that de facto all treatments should work the same for all patients regardless of the underlying risk of the disease. We do not share this notion and believe that most clinicians would not either.<sup>2,3</sup>More
Amaurosis Fugax
Authors: Jean-Claude Gautier
Journal: New England Journal of Medicine (1993)

Amaurosis fugax, or transient monocular blindness, is caused by an abrupt, temporary reduction in blood flow to one eye. The loss of vision is sudden, usually lasting seconds or minutes. Blindness is complete, although it is sometimes limited to a sector of the field of vision. Often the blindness develops as if a shade were drawn upward or downward over the eye, rarely sideward. Attacks can be single or multiple. Some patients have hundreds or even thousands of episodes. Pain, scintillations, and diplopia are typically absent. In most patients the prognosis for recovery of the retina is good; in a . . .
Differential effects of DI-sotalol vs. propafenone on global spatiotemporal complexity of local excitations in chronic atrial fibrillation: A determinant of defibrillation efficiency? Jiunn-Lee Lin, Ling-Ping Lai, Lian-Yu Lin, Chao-Cheng Du, Yung-Zu Tseng, Wen-Pin Lien, Shoei K. S. Huang. National Taiwan University Hospital, Taipei, Taiwan, ROC
Journal: Journal of the American College of Cardiology (2001)
Corrigendum to: “Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development” [January 2010; Vol. 52, Issue 1, Pages 72-78]
Authors: Shingo Nakamoto, Fumio Imazeki, Kenichi Fukai, Keiichi Fujiwara, Makoto Arai, Tatsuo Kanda, Yutaka Yonemitsu, Osamu Yokosuka
Journal: Journal of Hepatology (2009)
Late displacement of cardiac pacemaker electrode due to heavyweight pulse generator
Authors: G. E. Kim
Journal: JAMA (1974)

ENDOCARDIAL pacing has been shown to be a satisfactory method for long-term cardiac pacing. The electrode complications of malposition, displacement, fracture, migration, and perforation have been well described in previous publications.<sup>1,2</sup>We have recently observed a retraction of the endocardial electrode by the downward migration of the heavy pulse generator. This complication is prevented by anchoring the pacemaker to the clavicle or by creating a pacemaker "pocket" under the pectoral muscle or both. <h3>Report of Cases</h3> A 78-year-old man was admitted to New York University Hospital with intermittent heart block requiring cardiac pacing. A Medtronic pacemaker weighing 200 gm was inserted in a subcutaneous infrapectoral pocket with a bipolar electrode inserted via the cephalic vein into the apex of the right ventricle. Postoperatively the patient did well until the 12th month when failure of capture was noted. Chest x-ray film showed retraction of the catheter into the right atrium
Sprays May Cause Delayed Keratitis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BJSM reviews: A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 8
Authors: L M Castell, L M Burke, S J Stear, R J Maughan
Journal: British Journal of Sports Medicine (2010)

<h3>Abstract</h3> Single-nucleus RNA sequencing (snRNA-seq) measures gene expression in individual nuclei instead of cells, allowing for unbiased cell type characterization in solid tissues. Contrary to single-cell RNA seq (scRNA-seq), we observe that snRNA-seq is commonly subject to contamination by high amounts of extranuclear background RNA, which can lead to identification of spurious cell types in downstream clustering analyses if overlooked. We present a novel approach to remove debris-contaminated droplets in snRNA-seq experiments, called Debris Identification using Expectation Maximization (DIEM). Our likelihood-based approach models the gene expression distribution of debris and cell types, which are estimated using EM. We evaluated DIEM using three snRNA-seq data sets: 1) human differentiating preadipocytes <i>in vitro</i>, 2) fresh mouse brain tissue, and 3) human frozen adipose tissue (AT) from six individuals. All three data sets showed various degrees of extranuclear RNA contamination. We observed that existing methods fail to account for contaminated droplets and led to spurious cell types. When compared to filtering using these state of the art methods, DIEM better removed droplets containing high levels of extranuclear RNA and led to higher quality clusters. Although DIEM was designed for snRNA-seq data, we also successfully applied DIEM to single-cell data. To conclude, our novel method DIEM removes debris-contaminated droplets from single-cell-based data fast and effectively, leading to cleaner downstream analysis. Our code is freely available for use at https://github.com/marcalva/diem.
Abstract 037: The Association of Early Menarche and Changes in LDL-C During Adolescence for African-American and White Girls
Authors: Jill G Dreyfus, David R Jacobs, Ellen W Demerath
Journal: Circulation (2013)

Introduction: LDL cholesterol transiently decreases during puberty, and then increases again in late adolescence. However, the association of earlier pubertal development and LDL-C changes among adolescents is not well established, especially among African-American girls. Objective: To examine race-specific associations of early menarche and change in LDL-C during adolescence. Methods: The National Growth and Health Study (NGHS) was a 10-year prospective study of 2,379 girls, aged 9-10 at baseline, from four areas of the United States. Girls with missing age at menarche (n=22) or clinic (n=1) information were excluded from analyses. We used mixed effects regression models to test the association of early menarche, defined as less than median age at menarche for race in NHANES III (&lt;12.1 for African-American, and &lt;12.6 years for white girls) and serial measures of LDL-C, adjusted for age, study center, parental education, and percent body fat at each visit. Time was defined as follow-up year 1 (mean age 10) through year 10 (mean age 19), and included as a quadratic term in all models. Results: The analytic sample included 2,356 girls (1,200 African-American; 1,156 white). Early (vs. later) menarche (-1.90 mg/dl, p=0.05) and African American race (-1.72 mg/dl, p =0.08) were associated with lower average LDL-C over the 10-year time period. LDL-C increased less during late adolescence in African-American than in white girls (β race*time 2 = -0.11 mg/dl; p-interaction=0.01), and further, the relationship of menarche to the shape of the LDL-C curve differed by race, as indicated by different quadratic time terms (race*menarche*time 2 ; p-interaction=0.02). Conclusion: LDL-C was lower among girls with early vs. later menarche during adolescence. By late adolescence, white girls with early menarche tended to experience faster gains in LDL-C compared with later maturing white girls. Additional research is needed to determine if this pattern continues into adulthood.
Exchanges
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<TITLE>Weighing difficult choices</TITLE>
Journal: JAMA (1998)

Watchful Waiting" -Sometimes not treating the cancer immediately may be the preferred option because the growth of the cancer is often slow and may not cause significant problems for the rest of a man's life.The cancer is monitored closely, with other treatments (see below) used when appropriate.More aggressive therapy may not be advisable or necessary for men older than age 75.
Radiology
Authors: R. G. Evens
Journal: JAMA (1995)

Mammography continues to be an important and controversial topic in diagnostic imaging. Last year's Contempo issue reported on the debate on whether women younger than 50 years should undergo screening—a debate that continues in 1995. A recent report<sup>1</sup>finds that radiologists' interpretation of mammograms can differ, sometimes substantially. That radiologists' opinions differ and interpretive skills vary is not unexpected, but when this is reported about a procedure that is recommended for screening of all women older than 50 years and younger women who are at risk, it becomes newsworthy and of interest to the public, as well as the profession. On a positive note, this same report focuses attention on the need to improve the professional aspect of mammography screening, certainly at least as important as improving the technical performance of the procedure that has received the most attention during the past few years. It is an important challenge
Cryosurgery in nose and throat tumors
Authors: R. T. Barton
Journal: JAMA (1968)

Cryosurgery has been used successfully in treating certain pharyngeal neoplasms which were considered radioresistant and inoperable. There are definite limitations to the effectiveness of the technique and it is not without significant complications. The observation period in most cases has been about three years. The positive results, therefore, are hopefully curative rather than merely palliative.
Pilot Study Of Regulatory T Cell Depletion In The Setting Of Autologous Stem Cell Transplantation For Multiple Myeloma
Authors: Gottfried von Keudell, Cara A Rosenbaum, Todd M. Zimmerman, Michael Bishop, Koen van Besien, Rebecca Malloy, Amittha Wickrema, Andrzej Jakubowiak, Justin Paul Kline
Journal: Blood (2013)
The Body
Authors: Zeynep Uzumcu
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary embolectomy. Retrograde approach without use of a heart-lung bypass
Authors: W. H. Janke
Journal: JAMA (1968)

Pulmonary angiograms of patients with massive pulmonary embolism will often demonstrate complete occlusion of one pulmonary artery with little involvement of the other lung. In this group of patients, a unilateral pulmonary embolectomy through a posterolateral approach will afford a simple way of performing a meticulous cleaning of the affected pulmonary artery and all its branches. This method was used successfully in a 64-year-old woman.
Concentrations of the domestic house dust mite allergen Der p I after treatment with solidified benzyl benzoate (Acarosan) or liquid nitrogen.
Authors: S Kalra, P Crank, J Hepworth, C A Pickering, A A Woodcock
Journal: Thorax (1993)

BACKGROUND: Various methods of killing the house dust mite to reduce exposure to allergen are being promoted even though complete data on their effects on allergen concentrations are not available. A study was designed to measure the concentrations of the main house dust mite allergen Der pI in homes treated with either solidified benzyl benzoate (Acarosan) or liquid nitrogen. METHODS: Der pI concentrations were measured in dust collected from mattresses, bedroom carpets, and living room carpets in 10 houses treated with Acarosan and 10 houses treated with liquid nitrogen. Samples were collected before the treatment (in July 1990) and three and six months afterwards (October 1990 and January 1991). Forty untreated houses were concurrently sampled as controls. RESULTS: Der pI concentrations were similar in the three groups at baseline. No significant fall was seen in either of the two treated groups three or six months after treatment. Concentrations in the control houses increased significantly--twofold to threefold in dust sampled from mattresses and bedroom carpets between baseline and October 1990. This increase was not seen in either of the treated groups of houses, but there was no significant difference in the Derp pI concentrations in these houses and the control houses from any site at any time point. CONCLUSIONS: Neither Acarosan nor liquid nitrogen reduced the concentrations of Der pI for as long as six months after application. A small effect was probably present as the rise seen in control houses in the three month samples was not found in the treated houses. This effect, however, is likely to be of little clinical importance and also to be transient as the trend was lost by six months.
The Manufacture of Antitoxins.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aspartame
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clostridial Myonecrosis
Authors: Arthur B. Lee
Journal: JAMA (1981)

CLOSTRIDIAL organisms are ubiquitous and are found in soil, clothing, and other fomites. They are naturally occurring saprophytes of the gastrointestinal tract and genitourinary tract in humans. Nevertheless, serious clinical infection in man is rare. We describe a patient with myonecrosis secondary to<i>Clostridium septicum</i>. Initially, he had right thigh pain, and later subcutaneous crepitance developed. At surgery, an incarcerated right obturator hernia and extensive right thigh and buttock myonecrosis were found. It is believed that this patient's death was related to extensive myonecrosis secondary to direct extension of<i>C septicum</i>infection from an incarcerated obturator hernia. <h3>Report of a Case</h3> For two weeks prior to admission, a 58-year-old nondiabetic dialysis patient, with end-stage renal disease secondary to chronic glomerulonephritis, complained of intermittent crampy pain in the right lower quadrant. Approximately 24 hours before admission, he had an uneventful dialysis but subsequently came to the emergency room three times complaining
STATUS LYMPHATICUS
Authors: A. W. Squires
Journal: JAMA (1960)

<h3>To the Editor:—</h3> InThe Journal, April 16, page 68, "From Other Pages" is a portion of a paper by Dr. W. B. Bean entitled "Mythical Maladies." Referring to the belief that an enlargement of the thymus gland might in some way be responsible for sudden death in infants, Dr. Bean said, "Legend has it that status lymphaticus was recognized 300 years ago. Actually it had no currency before the early years of the present century. Its origin probably lies in a paper published by Paltauf in 1889." Finally, he stated that "In the 1930's it seemed increasingly probable that physicians were fretting about a nonexistent disease." There is material available which provides unquestionable evidence that the subject of thymic enlargement and its implications were thoroughly discussed much earlier than 1889. I have recently been perusing some old volumes of<i>The Medical Times and Gazette</i>(London). In the issue of