tbuckley/cabot-search huggingface dataset:
Prevention of Perinatal Transmission of Hepatitis B Virus: Prenatal Screening of all Pregnant Women for Hepatitis B Surface Antigen
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The danger of cocaine
Authors: W. Pollin
Journal: JAMA (1985)

Cocaine's great danger has not as yet been adequately recognized, either by the general public or by most physicians. Historically, the price of cocaine has served as a barrier to widespread use. Recently, however, there has been a substantial increase in acreage devoted to the growth of the coca bush, from which cocaine is derived. The consequent possibility of decreased prices and substantial increases in its use, as has already occurred in a number of South American countries, is therefore very real. Thus, it is essential that the widespread impression that the drug is comparatively benign be rapidly corrected. The article by Bozarth and Wise<sup>1</sup>in this issue shows that in rats given free access to heroin or cocaine, cocaine is three times as lethal to them as heroin. Their study showed that after one month, a remarkable 90% of animals with free access to cocaine were dead, compared
Survival benefits of fibrinolysis and early aspirin in acute myocardial infarction are sustained
Journal: BMJ (1998)

Survival benefits of fibrinolysis and early aspirin in acute myocardial infarction are sustained Fibrinolytic therapy for patients with acute myocardial infarction has short term survival benefits, but information about long term effects is limited.Baigent et al (p 1337) report long term survival data from the ISIS-2 trial of intravenous streptokinase and one month's oral aspirin in suspected acute myocardial infarction.They found that the early survival benefits of fibrinolytic therapy persist for at least 10 years and do not seem to increase or decrease with prolonged follow up in any category of patients, including elderly patients.The survival benefits of aspirin also persist and are additional to those of fibrinolytic therapy.
Blut, Munich
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environmental quality: its significance in our society
Authors: W. R. Barclay
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CASE OF CONGENITAL PANCREATIC CYST
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Council on Pharmacy and Chemistry
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Children's Tonsils In Or Out. A Critical Study of the End Results of Tonsillectomy . By Albert D. Kaiser, M.D., Associate Professor of Pediatrics, University of Rochester Medical School; Chief Pediatrician, Rochester General Hospital; Pediatrician, Rochester Dental Dispensary. J. B. Lippincott Company, Philadelphia. Price $5.00.
Journal: New England Journal of Medicine (1933)
Inhibition of Intercellular Communication between Normal Human Embryonal Palatal Mesenchyme Cells by Teratogenic Glycol Ethers
Authors: Frank Welsch, Donald B. Stedman
Journal: Environmental Health Perspectives (1984)

Cell-cell communication, possibly through gap junctions, is a fundamental event for the differentiation of embryonal tissues. Chemical substances which can interfere with this process may be able to disrupt embryogenesis. We have examined the response of a normal diploid human embryonal palatal mesenchymal (HEPM) cell line to glycol ethers. These cells have gap junctions whose function in cell-cell communication was inhibited by a model teratogen. Potential HEPM donor cells (2000 to 4000) were pulse labeled with 3H-uridine (10 microCi/mL; 3 hr) and then cocultured for 3 hr with 200,000 to 400,000 potential recipient cells in the absence or presence of 2-methoxyethanol (ME; 0.13-0.30 M) or 2-isopropoxyethanol (IPE; 0.05-0.1 M). Computer-assisted quantitative autoradiography was applied to assess the effects on metabolic cooperation. Although this phenomenon was inhibited by ME, the effect was probably not attributable to interference with gap junction-mediated transfer of labeled nucleotides but rather to the lack of formation of gap junctions resulting from cytotoxicity and poor physical contact between cells. The inhibition obtained with IPE was apparently not due to adverse effects on HEPM cells as judged by light microscopy and cell counts of recipients surrounding a given donor. The results suggest that HEPM cells are suitable to study disruption of cell-cell communication as a mechanism responsible for teratogenesis and offer the unique possibility to apply human embryonal cells. However, care has to be taken to assess potential cytotoxicity of xenobiotics, and further refinement of the criteria to detect adverse effects is required.
Highlights
Authors: Howard Bauchner
Journal: JAMA (2017)

Peripheral Artery Disease and Walking Performance 2089Interventions that increase circulating endothelial progenitor cells may improve walking performance in patients with lower extremity peripheral artery disease.In a randomized trial of 210 patients with peripheral artery disease, McDermott and colleagues found that supervised treadmill exercise, but not treatment with granulocyte-macrophage colonystimulating factor, improved 6-minute walk distance.CME jamanetwork.com/learning
Real-life efficacy and safety of direct-acting antivirals in patients with liver cirrhosis and history of hepatic decompensation: EpiTer-2 study
Authors: Aleksandra Berkan-Kawińska, Piekarska Anna, Dorota Zarębska-Michaluk, Marek Sitko, Aleksander Garlicki, Hanna Berak, Horban Andrzej, Ewa Janczewska, Agnieszka Czauż-Andrzejuk, Wlodzimierz Mazur, Magdalena Tudrujek, Krzysztof Tomasiewicz, Beata Dobracka, Iwona Orłowska, Simon Krzysztof, Pawel Pabjan, Łukasz Socha, Łukasz Laurans, Dorota Dybowska, Waldemar Halota, Małgorzata Pawłowska, Beata Lorenc, Jerzy Jaroszewicz, Robert Flisiak
Journal: Journal of Hepatology (2020)
Family practice
Authors: R. E. Rakel
Journal: JAMA (1989)

Events of the past 10 years have left many physicians reeling from professional shock and wondering how the practice of medicine as they once knew it could have changed so dramatically. Increasing competition, the advent of prospective payment and managed care, the evolving role of peer review, the malpractice crisis, and other changes have introduced new challenges to medicine, challenges that have tested many physicians' enthusiasm for their chosen profession. Even so, a more far-reaching change looms on the horizon, a change that will reflect a growing public-policy mandate and bring to full circle the philosophical course charted a quarter-century ago through Medicare. Despite having what some people consider the best health care system in the world, many Americans find themselves on the outside looking in. Over 40 million people are disenfranchised from health care to one extent or another by not having adequate health insurance. Many of these people
CORRECTIONS
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: P. J. CREAVEN
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BOOK REVIEWS Get access Platinum and Other Metal Co-ordination Compounds in Cancer Chemotherapy. Marino Nicolini, ed. Dordrecht, The Netherlands: Nijhoff, 1988, 767pp. $165. PATRICK J. CREAVEN PATRICK J. CREAVEN Department of Clinical Pharmacology and Therapeutics, Roswell Park Memorial Institute666 Elm Street, Buffalo, NY 14263 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 13, 7 September 1988, Page 1074, https://doi.org/10.1093/jnci/80.13.1074 Published: 07 September 1988
Primary sclerosing cholangitis in 32 children: Clinical, laboratory, and radiographic features, with survival analysis*1
Authors: M WILSCHANSKI
Journal: Hepatology (1995)

The clinical presentation and outcome of 32 children with primary sclerosing cholangitis (PSC) are reviewed, the largest North American series. The majority of patients were diagnosed in their second decade (median age: 13 years). Four children presented before the age of 2 years, but none in the neonatal period. Seventeen patients had inflammatory bowel disease (IBD), all with colitis, 14 ulcerative colitis, and 3 Crohn's disease. Eight patients presented with chronic liver disease before clinical onset of IBD. Only 8 of 32 patients were jaundiced at presentation. Fifteen of 32 had a normal serum alkaline phosphatase (ALP) level at presentation. Nine children presented with features similar to those of autoimmune hepatitis. Cholangiography was performed in all cases and classified by a scoring system specifically developed for pediatric patients. Intrahepatic disease predominated; in only three cases a common bile duct stricture was identified requiring stenting. Findings on the initial liver biopsy were classified according to Ludwig's criteria for staging PSC: there were 15 biopsies in stages 1 to 2 and 17 biopsies stages 3 to 4. HLA class I and II antigens were determined in 27 patients. An increased incidence of HLA B8 and DR2(15) but not DRw52a (DRB3∗0101) was found. Anti-neutrophil cytoplasmic antibody (ANCA) was positive in 10 of 24 patients tested. Survival analysis indicated that a later age at presentation, splenomegaly, and prolonged prothrombin time (PT) at presentation were significant contributors to the prediction of poor outcome (i.e., death or listing for transplantation). Liver transplantation was successfully performed in seven children. Physicians must maintain a high index of suspicion of PSC in any child or young adult presenting with chronic liver disease, especially in the presence of IBD, even with a normal serum alkaline phosphatase level.
Transformation of Human Osteoblasts to Anchorage-Independent Growth by Insoluble Nickel Particles
Authors: Xinhua Lin, Max Costa
Journal: Environmental Health Perspectives (1994)

Nickel compounds are well established by epidemiologic studies as human carcinogens.Although the carcinogenicity of nickel compounds has been studied in experimental animals and in a variety of cultured mammalian cells, there are only sporadic reports of nickel-induced transformation of human cells.In attempts to study the mechanisms of nickel-induced carcinogenesis in human cells, an immortalized human osteoblastic cell line (HOS) that could not grow in soft agar or form tumors in athymic nude mouse was repeatedly treated with a water-soluble nickel compound (NiCI2) or a less water-soluble nickel compound crystalline (NiS).After three rounds of NiS treatments, there was an increase in anchorage-independent (Al) colony formation.This was not found in untreated or NiCI2-treated cells.Ten Al colonies obtained from NiS-treated cells were isolated.All of these clones showed changes in cell morphology, including the appearance of uniform polygon shape, growth in multilayers, and heavy staining with Giemsa.Most of these clones were retested for their ability to grow in soft agar and showed growth efficiencies of 5 to 50%.It has been shown by other investigators that aggregate growth is well correlated with tumorigenic potential in viral or chemical transformants of HOS cells.Four of seven tested NiS-transformed clones were able to form large aggregates compared to their untransformed counterparts, and continued to proliferate in aggregate form when they were plated on 0.9% agar.Current investigations focus on the molecular and genetic changes induced by nickel com- pounds in these human cells.
Eternal Eve: The History of Gynaecology &amp; Obstetrics
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Terminology
Authors: Bernard Notes
Journal: JAMA (1975)

<h3>To the Editor.—</h3> In the QUESTIONS AND ANSWERS section (233:823, 1975), the question arises, "when is augmentation mammoplasty after mastectomy feasible?" The questioner and answerer speak of "augmentation mammoplasty" and "reconstruction of the breast after mastectomy." Such fallacious terminology does not, in my opinion, meet the usual standards of the prestigious<i>JAMA</i>as used in connection with the statement "mastectomy after carcinoma of the left breast 18 months ago." This so-called augmentation mammoplasty or reconstruction of the breast after mastectomy is, in reality, a<i>cosmetic</i>procedure, frequently including a prosthesis that attempts, often with indifferent results, to develop (not to create or reconstruct or augment) a breast-appearing mass, together with a pseudonipple.
Scintillation camera renography in superior infundibular obstruction
Authors: J. C. Harbert
Journal: JAMA (1969)

Five patients with superior infundibular obstruction were studied with scintillation camera renography. The renogram tracings in all patients showed prolonged transit time and flattening of the excretory phase. The scintiphotos accurately localized the site of tracer retention to the superior collecting system of the involved kidney.
Dengue Fever Among U.S. Military Personnel—Haiti, September-November, 1994
Journal: JAMA (1995)

Since September 19, 1994, approximately 20,000 U. S. military personnel have been deployed to Haiti as part of Operation Uphold Democracy. To monitor the occurrence of mosquitoborne illnesses (including dengue fever [DF] and malaria) among deployed military personnel, on September 19 the U. S. Army established a surveillance system for febrile illness. Before deployment, all military personnel were instructed to take antimalarial chemoprophylaxis, either chloroquine phosphate (500 mg weekly) or doxycycline (100 mg daily). This report summarizes surveillance findings for September 19-November 4.(ABSTRACT TRUNCATED AT 250 WORDS)
Vitamin Supplementation in Health and Disease
Authors: Perry J. Culver
Journal: New England Journal of Medicine (1949)

Newer VitaminsDuring the last four years, an important place in medical literature has been given to the discovery and therapeutic uses of three newer vitamins that promise much for man. These three substances are folic acid, vitamin B12 and rutin or vitamin P. At present it is impossible to ascertain whether the clinical response to these supplements is due to alleviation of a deficiency of the specific newer factor or whether benefit results from a pharmacologic effect. Folic Acid The fast-moving history of the discovery, identification, synthesis, physiology and therapeutic uses of folic acid was well reviewed by . . .