tbuckley/cabot-search huggingface dataset:
Correction: Argon plasma coagulation for Barrett’s esophagus with low-grade dysplasia: a randomized trial with long-term follow-up on the impact of power setting and proton pump inhibitor dose
Authors: Ewa Wronska, Marcin Polkowski, Janina Orlowska, Andrzej Mroz, Paulina Wieszczy, Jaroslaw Regula
Journal: Endoscopy (2020)

Correction to: Argon plasma coagulation for Barrett’s esophagus with low-grade dysplasia: a randomized trial with long-term follow-up on the impact of power setting and proton pump inhibitor doseEndoscopy 2021; 53(02): 123-132DOI: 10.1055/a-1203-5930
Resistance and phylogenetic analysis in HCV-2c infected patients within the Italian network VIRONET-C
Authors: Velia Chiara Di Maio, Silvia Barbaliscia, Lavinia Fabeni, Elisabetta Teti, Stefania Paolucci, Carmine Minichini, Marianna Aragri, Katia Yu La Rosa, Caterina Pasquazzi, Martina Milana, Luca Foroghi, Teresa Pollicino, Anna Licata, Alessandro Pieri, Valeria Pace Palitti, Bianca Bruzzone, Valeria Micheli, Ada Bertoli, Leonardo Baiocchi, Maria Paola Callegaro, Luca Carioti, Adriano Pellicelli, Filomena Morisco, Roberto Gulminetti, Stefano Novati, Miriam Lichtner, Claudio M. Mastroianni, francesco Di Lorenzo, Pietro Andreone, Barbara Rossetti, Simona Marenco, Gloria Taliani, Enzo Boeri, Hamid Hasson, Laura Monno, Laura Ambra Nicolini, Simona Landonio, Claudio Paternoster, Massimo Puoti, Sergio Babudieri, Mariano Quartini, Nerio Iapadre, Raffaele Cozzolongo, Vincenzo Sangiovanni, Giustino Parruti, Loredana Sarmati, Nicola Coppola, Maurizio Zazzi, Giovanni Raimondo, Angelico Mario, Carlo-federico Perno, Massimo Andreoni, Antonio Craxi, Francesca Ceccherini Silberstein
Journal: Journal of Hepatology (2020)
Failure of hyposensitisation in treatment of children with grass-pollen asthma
Authors: D J Hill, C S Hosking, M J Shelton, M W Turner
Journal: BMJ (1982)

Twenty asthmatic children with laboratory proved bronchial reactivity to rye-grass pollen were studied over two consecutive grass-pollen seasons.In the first year 11 patients received preseasonal hyposensitisation treatment with an aqueous rye extract and nine received placebo injections.No treatment was given in the second year.Patients in both the active-treatment and placebo groups showeda pronouncedclinical deterioration in their asthma during both pollen seasons.Serum concentra- tions of IgG-specific antibodies to the rye allergen before treatment were similar in both groups, but after immunotherapy and before the pollen season in the first year these antibody concentrations were raised significantly in the treated group (p< 0 005): by the middle of the pollen season the difference was no longer significant.IgE-specific antibodies showed a similar but non- significant pattern of response.We found no evidence that limited hyposensitisation with a pollen extract is of any clinical benefit in seasonal asthma despite evidence of an immunological response.
Study of Premature Infants Fed Cold Formulas
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atmospheric Factors Evaluated in Asthma Therapy
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pottery Evidences of Leprosy.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4373: Lack of FGF21 promotes NASH-HCC transition via exosome-mediated carcinogenetic signaling
Authors: Youxi Yu, Robert C. Martin, Qianqian Zheng, Xiaoju Shi, Xingkai Liu, Wei Guo, Suping Li, Ping Zhang, Yan Li
Journal: Cancer Research (2019)

Abstract Background: Nonalcoholic steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease (NAFLD) and a potential precursor of hepatocellular carcinoma (HCC). FGF21, with its metabolic benefits, was reported as the liver safeguard to protect from obesity, diabetes, and NAFLD. Recent study showed an exosome based FGF21 inhibition via organs communication to regulate hepatic metabolism. However, the role of the exosome-FGF21 axis in NASH-HCC has never been studied. Aim: To study the exosome based FGF21 metabolic regulation during NASH-HCC carcinogenetic transformation. Methods: NASH-HCC model was induced in FGF21 knockout (KO) mice and wild type (WT) control using methionine-choline-deficient diets (MCD) and diethylnitrosamine (DEN). The exosomes releasing, miRNA and protein contents were analyzed in the primary cultured hepatocytes from the liver tissues of NASH-HCC mice (KO and WT) as well as benign controls. FGF21 was knockdown (KD) by shRNA in a mouse hepatoma cell line (Hepa1-6) and a benign mouse hepatocyte cell line (FL83B) to investigate the potential carcinogenetic signaling related to exosome-FGF21 axis. Result: NASH-HCC model was successfully established with confirmation of the metabolic disorders and liver cancer development. Early HCC detection and increased HCC incidence were found in the KO-MCD mice (P&amp;lt;0.05 versus KO-CD and WT controls). The collected exosomes from primary cultured hepatocytes and cell lines were identified using the antibodies of Tsg101, CD63 and cytochrome C by western blotting and immunofluorescent staining. In the KO-MCD mice, exosomes retained in the cytosol of benign hepatocyte but released increasingly from cancer cell. Similar results were showed in the Hepa1-6KD cells and the FL83BKD cells. Aberrant EMT, and p53 and Wnt signaling was found in the KO-MCD mice as well as Hepa1-6KD cells challenged with free fatty acid. Conclusion: lack of FGF21 plays critical role for the exosome retention in hepatocytes of NASH mice but not in HCC mice. Abnormal traffic of exosomes contribute to the carcinogenetic signaling. This work was supported by an Institutional Development Award (IDeA) from the NIGMS of the National Institutes of Health under grant number P20GM113226. Citation Format: Youxi Yu, Robert C. Martin, Qianqian Zheng, Xiaoju Shi, Xingkai Liu, Wei Guo, Suping Li, Ping Zhang, Yan Li. Lack of FGF21 promotes NASH-HCC transition via exosome-mediated carcinogenetic signaling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4373.
Prognostic factors and survival of patients with brain metastasis (BM) from breast cancer (BC) who underwent craniotomy.
Authors: Jose Pablo Leone, Diana E. Cunningham, Adrian Lee, Rohit Bhargava, Ronald L. Hamilton, Erik Wiener, Hideho Okada, Adam Brufsky
Journal: Journal of Clinical Oncology (2013)

143 Background: BC is the second most frequent cause of BM after lung cancer, with metastases occurring in 10% - 16% of all patients. BM in patients with BC is a catastrophic event that results in poor prognosis. Identification of prognostic factors associated with breast cancer brain metastases (BCBM) could help to identify patients at risk. The aim of this study was to assess clinical characteristics, prognostic factors and survival of patients with BCBM who had craniotomy and resection in a series of patients treated with modern multimodality therapy. Methods: We analyzed 42 patients with BCBM who underwent resection. Patients were diagnosed with BC between April 1994 and May 2010. Cox proportional hazards regression was selected to describe factors associated with time to BM, survival from the date of first recurrence, and overall survival (OS). Results: Median age was 51 years (range 24-74). Median follow-up was 4.2 years (range 0.6-18.5). The mean time to BM from primary diagnosis was 49 months (range 0-206.22). Patients had a median of 2 BM with a median size of 3.25 cm. The proportion of the biological subtypes of BC was ER+/HER2- 25%, ER+/HER2+ 15%, ER-/HER2+ 30% and ER-/HER2- 30%. Brain radiotherapy was given to 28 patients, of which 10 had stereotactic radiosurgery, 7 whole brain radiation, and 11 both. Median OS from the date of primary diagnosis was 5.74 years. Median survival after diagnosis of BM was 1.33 years. In multivariate Cox regression analyses, stage was the only factor associated with shorter time to the development of BM (P=0.059), whereas age was the only factor associated with survival from the date of recurrence (P=0.027) and with OS (P=0.037). Controlling for age and stage, neither the biological subtype of cancer, the radiation modality nor the site of first recurrence showed any impact on survival. Conclusions: Stage at primary diagnosis correlated with shorter time to the development of BM, while age at diagnosis was associated with shorter survival in BCBM. None of the other clinical factors had influence on survival.
Future research needs associated with the assessment of potential human health risks from exposure to toxic ambient air pollutants
Authors: L Möller, D Schuetzle, H Autrup
Journal: Environmental Health Perspectives (1994)

This paper presents key conclusions and future research needs from a Workshop on the Risk Assessment of Urban Air, Emissions, Exposure, Risk Identification, and Quantification, which was held in Stockholm during June 1992 by 41 participants from 13 countries.Research is recommended in the areas of identification and quantification of toxics in source emissions and ambient air, atmospheric transport and chemistry, exposure level assessment, the development of improved in vitro bioassays, biomarker development, the development of more accurate epidemiological methodologies, and risk quantification techniques.Studies are described that will be necessary to assess and reduce the level of uncertainties associated with each step of the risk assessment process.International collaborative research efforts between industry and government organizations are rec- ommended as the most effective way to carry out this research.-
A phase Ib/II study of second-line therapy with panitumumab, irinotecan, and everolimus (PIE) in metastatic colorectal cancer with KRAS wild type (WT).
Authors: A. R. Townsend, L. Pirc, J. Hardingham, C. S. Karapetis, N. C. Tebbutt, N. Singhal, T. J. Price
Journal: Journal of Clinical Oncology (2011)

TPS162 Background: Activation of the EGFR results in cell proliferation and survival via the RAS/RAF/MAPK, and PI3K/PTEN/AKT signalling pathways. Mutations in the KRAS gene result in a constitutively active protein that is independent of the EGFR and therefore is not inhibited by anti-EGFR monoclonal antibodies. However, recent retrospective studies have shown that aberrations in other down stream signalling molecules also confer resistance to EGFR antagonists, including mutations in BRAF and PI3K, and loss of the PTEN tumour suppressor molecule. The mammalian target of rapamycin (mTOR) is a key downstream regulatory protein that is activated via the PI3K-AKT pathway, and regulates cell growth, proliferation, and survival. Inhibition of mTOR in addition to blockade of the EGFR may cause a more profound anti-tumour effect by overcoming upstream mechanisms of resistance. In EGFR-resistant colon cancer cell lines, in vitro and in vivo studies of the combination of everolimus and an EGFR inhibitor resulted in reduced tumour growth and resensitised resistant cancer cells to EGFR inhibition (Bianco. B J Cancer 2008:923-930). Methods: This is a phase Ib/II, open label, non-randomised study. Eligibility criteria include age ≥ 18 years, metastatic colorectal cancer that is KRAS wild type, following failure of first-line oxaliplatin and fluoropyrimidine combination chemotherapy, with adequate bone marrow reserve and organ function. Patients receive IV irinotecan and panitumumab every 2 weeks, with everolimus administered orally thoughout the 14 day cycle. The starting dose is irinotecan 200mg/m2, panitumumab 6mg/kg, everolimus 5mg alternate days. Dose finding will use a standard 3+3 design with the MTD being defined as the dose with DLTs in 1/6 or fewer patients. Following determination of the MTD, the phase II component of the study will begin for which the primary endpoint is response rate. A total of 50 patients will be recruited. Correlation of response rate with BRAF mutation, expression of PTEN, ERK, AKT, mTOR, and pS6K will be performed.
COMMITTEE ON COSMETICS
Journal: JAMA (1952)

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Use of the Cryostat in Diagnosis with Frozen Sections of Specimens from Cervical Conization
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NEW SENSATION
Journal: JAMA (1961)

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WATER BY MOUTH FOR FEVER IN THE NEW-BORN
Journal: JAMA (1924)

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The Medical Department of the United States Army in the World War. Volume V: Military Hospitals in the United States.
Journal: JAMA (1923)

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ARTIFICIAL RIPENING OF FRUITS BY ETHYLENE
Journal: JAMA (1927)

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