tbuckley/cabot-search huggingface dataset:
John Devine
Journal: BMJ (2006)

served in the Royal Army Medical Corps in Normandy, Belgium, and Rhodesia before joining his brother in general practice in Bellshill in industrial Lanarkshire.After retirement in 1978 he did locum work.He was chairman of Lanarkshire Medical Committee for 12 years.In addition to an avid interest in politics, sport, crosswords, and puddings, he supplied family, friends and neighbours with plants annually, and grew show chrysanthemums, winning many prizes locally and nationally.He was chairman of the Scottish Chrysanthemum and Dahlia Society for many years.David survived cancer three times.
A patient with plaque-stage mycosis fungoides has successfully been treated with long-term administration of IFN-γ and has been in complete remission for more than 6 years
Authors: T. HORIKOSHI, H. ONODERA, H. EGUCHI, N. HANADA, K. FUKUZAWA, M. TAKAHASHI, K. ISHIHARA, S. IKEDA
Journal: British Journal of Dermatology (1996)
Response and long-term outcomes after neoadjuvant chemotherapy: Pooled dataset of patients stratified by molecular subtyping by MammaPrint and BluePrint.
Authors: Stefan Gluck, Femke De Snoo, Justine Peeters, George Somlo, Laura Van T Veer
Journal: Journal of Clinical Oncology (2012)

10597 Background: Classification of breast cancers into molecular subtypes may be important for the proper selection of therapy for patients with early breast cancer. Previous analyses had shown that breast cancer subtypes have distinct clinical outcome (Sorlie, PNAS, 2001; Esserman, BCRT, 2011). Herein, we analyze using MammaPrint together with an 80-gene molecular subtyping profile (BluePrint) the response to neo-adjuvant chemotherapy and long term outcomes. Methods: This study was carried out on data from 144 patients from the I-SPY I trial; 232 patients from biomarker discovery program at MD Anderson (133 and 99 respectively; Hess, 2006, JCO; Iwamoto, 2011, BCRT); and 68 patients from City of Hope (Somlo, ASCO, 2010). All patients were treated in the neo-adjuvant setting with standard chemotherapy. MammaPrint and BluePrint were determined on 44K Agilent arrays run at Agendia or available through the I-SPY 1 data portal, or from Affymetrix U133A arrays. MammaPrint and BluePrint resulted in 4 distinct molecular groups: Luminal A (MammaPrint Low-risk/Luminal-type), Luminal B (MammaPrint High-risk/Luminal-type), Basal-type and HER2-type. Results: The overall pCR of this patient cohort was 22% but differed substantially among the subgroups. pCR was observed in 5% of the Luminal-A samples and 10% of Luminal-B, in 39% of the HER2-type samples and in 33% of the Basal-type samples. Patients with Basal-type tumors had a 5-year DFS of 71%; HER2-type had a 5-year DFS of 67%(n=71); 69% in HER2-type subgroup not treated with HER2-targeted therapy (n=45); Luminal-B type had a 5-year DFS of 77% and Luminal-A type showed 5-year DFS of 95%. Conclusions: We observed marked differences in response and DFS to neo-adjuvant treatment in groups stratified by MammaPrint and BluePrint. These findings confirm differences in chemotherapy response among molecular subgroups and indicate that the BluePrint and MP profile used for this analysis helps to further establish a clinical correlation between molecular subtyping and treatment outcomes.
Imported Plasmodium falciparum malaria in American travelers to Africa. Implications for prevention strategies
Authors: E M Lackritz, H O Lobel, B J Howell, P Bloland, C C Campbell
Journal: JAMA (1991)

Data from the US National Malaria Surveillance System were analyzed to assess characteristics of travelers who acquired<i>Plasmodium falciparum</i>infections in Africa and evaluate the impact of chloroquine resistance on the incidence of imported malaria. Although the number of cases acquired in East Africa has stabilized, the number of imported<i>P falciparum</i>infections acquired in West Africa increased threefold from 1985 to 1988, and the proportion of travelers who reported failure of chloroquine prophylaxis increased from 10% to 48%. Fifty-eight percent of patients who acquired malaria in West Africa had not used chemoprophylaxis. To curb the rising incidence of<i>P falciparum</i>infections in American travelers, the Centers for Disease Control revised malaria prophylaxis recommendations to include the use of mefloquine in areas of chloroquine resistance. Use of malaria protection measures by travelers to West Africa must also be improved. (<i>JAMA</i>. 1991;265:383-385)
Address.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE OHIO MEDICAL PRACTICE ACT.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diclofenac hepatitis.
Authors: P Purcell, D Henry, G Melville
Journal: Gut (1991)

The characteristics of liver damage associated with the use of diclofenac, a popular nonsteroidal anti-inflammatory drug, were investigated by reviewing adverse drug reaction reports for Australia. Twenty six patients were reported for whom diclofenac was the sole suspected drug cause of their liver damage. The average age of the patients was 64 years (range 37-84 years); 19 (70%) were women. The most common clinical features were jaundice, hepatomegaly, anorexia, and nausea. Features of drug hypersensitivity were not reported. Duration of treatment with diclofenac before the onset of the illness ranged from 6-417 days (median 76 days). The most prominent biochemical abnormalities were raised serum aspartate transaminase and alanine transaminase activity of up to 30 to 40 times the upper limit of the normal range. Recovery generally started soon after withdrawal of diclofenac and the decrease in aspartate transaminase and alanine transaminase for the group was exponential, with half lives of around 13 days. The average total dose taken by 18 patients for whom accurate data were available was 8.7 g (range 1.4-63.5 g) and, unexpectedly, there was a significant relation between the logarithm of the dose of diclofenac and the logarithms of the peak and mean transaminase levels. Hepatocellular damage during treatment with diclofenac seems to be a rare event. From this analysis of Australian reports it seems that in a small subgroup of patients liver injury may be a direct toxic effect of diclofenac or a metabolite.
BOOK REVIEW
Authors: M. A. LEVINE
Journal: JNCI Journal of the National Cancer Institute (1995)

BOOK REVIEW Get access Breast Cancer: Controversies in Management Leslie Wise , Houston Johnson , eds. Armonk, N.Y. : Futura Publ. , 1994 . 592 pp., illus. $105. ISBN 0-87993-562-6 MARSHALL A. LEVINE, M.D. MARSHALL A. LEVINE, M.D. Director, Division of Oncology Dept. of Medicine Sinai Hospital of BaltimoreBaltimore, MD 21215 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 4, 15 February 1995, Pages 312–313, https://doi.org/10.1093/jnci/87.4.312 Published: 15 February 1995
Announcement: Sleep Awareness Week, April 23–29, 2017
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Sleep Awareness Week, the National Sleep Foundation's annual campaign to educate the public about the importance of sleep in health and safety, will be observed April 23-29, 2017. The amount of sleep a person needs changes with age. Adults need ≥7 hours each night to promote optimal health and well-being (1); children and adolescents require even more sleep. Sleep needs decrease from 12-16 hours of sleep per 24 hours (including naps) for infants aged 4-12 months to 8-10 hours of sleep for teenagers aged 13-18 years (2). Children who regularly sleep less than the recommended amount are more likely to have behavior and learning problems, physical and mental health conditions such as obesity, diabetes, depression, or injuries (2). A regular bedtime routine can help children get adequate sleep. The American Academy of Pediatrics provides advice for parents at https://www.healthychildren.org/English/healthy-living/sleep/. Additional details about how much sleep is recommended across a lifespan is available at https://www.cdc.gov/sleep/about_sleep/how_much_sleep.html.
Changes in Anesthesiology Practice Are Explicated
Authors: J. M. Torpy
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transmission of a homogenous hepatitis B virus population of A1896-containing strains leading to mild resolving acute hepatitis and seroconversion to hepatitis B e antigen antibodies in an adult
Authors: M Mphahlele
Journal: Hepatology (1997)

The pre-core variant, A1896, which switches off hepatitis B e antigen (HBeAg) production, is common in hepatitis B e antigen antibody (anti-HBe)-positive chronic hepatitis patients. It has been observed in occasional case reports of acute hepatitis. However, transmission in the absence of HBeAg-producing strains, leading to acute nonfulminant hepatitis and clearance in adults, has not been reported. Here, we show that this event can occur, further confirming that A1896 strains are “wild-type” and can lead to all the same outcomes as G1896 strains. This is in keeping with phylogenetic evidence that A1896 is transmitted independently on a large scale in the population and explains anti-HBe-positive persons who have not had an HBeAg-positive phase documented.
Magnetic Resonance Imaging and Mammography in Women With a Hereditary Risk of Breast Cancer
Authors: M. J. Stoutjesdijk, C. Boetes, G. J. Jager, L. Beex, P. Bult, J. H. C. L. Hendriks, R. J. F. Laheij, L. Massuger, L. E. van Die, T. Wobbes, J. O. Barentsz
Journal: JNCI Journal of the National Cancer Institute (2001)

Although breast cancer screening is recommended to start at a younger age for women with a hereditary risk of breast cancer, the sensitivity of mammography for these women is reduced. We compared magnetic resonance imaging (MRI) with mammography to determine which is more sensitive and whether MRI could play a role in the early detection of breast cancer for these women.We constructed a retrospective cohort of all breast MRI and mammography surveillance reports made in our department from November 1994 to February 2001. All of the 179 women in the cohort had received biannual palpation in addition to annual imaging by MRI, mammography, or both. The 258 MRI images and the 262 mammograms were classified with the use of the BI-RADS (i.e., Breast Imaging Reporting and Data System) scoring system, which has five categories to indicate the level of suspicion of a lesion. Receiver operator characteristic curves were generated for MRI and mammography, and the area under each curve (AUC) was assessed for the entire cohort of 179 women and for a subset of 75 women who had received both an MRI and a mammographic examination within a 4-month period. All statistical tests were two-sided.In the cohort of 179 women, we detected 13 breast cancers. Seven cancers were not revealed by mammography, but all were detected by MRI. For the entire cohort, the AUC for mammography was 0.74 (95% confidence interval [CI] = 0.68 to 0.79), and the AUC for MRI was 0.99 (95% CI = 0.98 to 1.0). For the subset of women who had both examinations, the AUC for mammography was 0.70 (95% CI = 0.60 to 0.80), and the AUC for MRI was 0.98 (95% CI = 0.95 to 1.0).MRI was more accurate than mammography in annual breast cancer surveillance of women with a hereditary risk of breast cancer. Larger prospective studies to examine the role of MRI in screening programs are justified.
Randomized double-blind placebo-controlled international trial of abagovomab maintenance therapy in patients with advanced ovarian cancer after complete response to first-line chemotherapy: The Monoclonal Antibody Immunotherapy for Malignancies of the Ovary by Subcutaneous Abagovomab (MIMOSA) trial.
Authors: J. Pfisterer, J. S. Berek, A. Casado, K. Cwiertka, T. Pinter, A. Pluzanska, E. Pujade-Lauraine, G. Scambia, J. B. Vermorken, C. Simonelli, M. Bertolotti, A. Capriati, P. Sabbatini
Journal: Journal of Clinical Oncology (2011)

LBA5002 The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed onsite at the Meeting on June 4, 2011, and as a supplement to the June 20, 2011, issue of Journal of Clinical Oncology.
Educational Progress.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Royal Medical Society of Edinburgh
Journal: BMJ (1902)

In another part of the present number, we have referred to this excellent and highly respectable Institution, the members of which resolved, on its completing its centenary, to celebrate the event by an appropriate festival.Accor- dingly, on Friday, the 17th February, this celebration took place, at the Hopetoun rooms.Owing to the season of the year, and the very general pre- valence of the influenza, members from a distance were, for the most part, pre- vented from attending; nevertheless, one hundred and sixteen individuals assembled on the occasion.The proceedings commenced with the delivery, by Mr. Carpenter, senior president, of an oration, which was characterized no less by eloquence and power than by elegance of style.The chief object of the orator was to detail the leading features of the history of the Institution, and to point out the numerous advantages which had accrued to medical science from its establishment.We regret that our limits prevent us from giving any lengthened extracts from this discourse.We must, however, quote part of a passage relating to the connexion of some of our most distinguished men, in the early part of their career, with this Society; a circumstance extremely inte- resting in the literary history of our profession.We are much mistaken if
Gram-negative sepsis with acute renal failure. Occurrence from acute glomerulonephritis
Authors: A. R. Zappacosta
Journal: JAMA (1977)

Acute intrinsic renal failure occurred in an adult patient with<i>Escherichia coli</i>septicemia. The clinical course did not include any of the circumstances usually present when acute renal failure complicates Gram-negative sepsis. A renal biopsy showed acute proliferative glomerulonephritis. There was no evidence to support other known causes of acute parenchymal renal failure, such as poststreptococcal glomerulonephritis, subacute bacterial endocarditis, or vasculitis. The patient recovered completely with antibiotic therapy, and renal function returned to normal within two weeks. An immunologic mechanism involving<i>E coli</i>was considered responsible for the acute renal failure. (<i>JAMA</i>238:1389-1390, 1977)
Abstract 184: An Atypical Presentation of Incomplete Kawasaki Disease
Authors: Mario Briceno-Medina, Michael Perez, Benjamin R Waller, Shyam Sathanandam
Journal: Circulation (2015)

Background: Kawasaki disease (KD) is a systemic panvasculitis that can cause coronary artery aneurysms (CAA) in up to 25% if left untreated. Rarely, aneurysms of other medium-sized arteries have also been reported to occur. The incidence of systemic artery aneurysms (SAA) with typical KD can be as high a 2.2%. Incomplete KD with SAA is not well described. We report a case of diffuse SAA in a 12-year-old boy with incomplete KD and giant CAA. Case Presentation: The patient presented with fever, malaise, abdominal pain, rash and cervical lymphadenopathy. Suspicion for the presence of a pericardial effusion on an abdominal CT scan prompted echocardiographic assessment. By echo, multiple giant CAA in all three coronary arteries was noted. Incidentally, on an aortogram after performing pericardiocentesis, it was noted that he had diffuse ectasia and aneurysms of every arterial branch off the aorta. Selective angiograms confirmed the presence of aneurysms in all medium-sized arteries throughout the body including pulmonary arteries. The patient was treated with IVIG, methylprednisolone and high dose aspirin. Incomplete KD was suspected. However, because of the systemic vasculitis, cyclophosphamide therapy was administered. Patient responded well to therapy with improvement in clinical symptoms. Anticoagulation with heparin was transitioned over to maintenance warfarin therapy. Patient remains asymptomatic 2 years later with large, but stable CAA. Conclusions: Incomplete KD can manifest with giant CAA and SAA. Immunosuppressant therapy may be necessary for systemic involvement. Anticoagulation is needed to prevent thromboembolic manifestations.
Family practitioner committees: a price for independence?
Journal: BMJ (1985)

the report into medical, social, and those related to the law, and further categorised into those associated with intoxication (for example, alcoholic poisoning, head injury, drug over- dose, domestic violence, child neglect and abuse, absenteeism, road traffic accidents, drinking and driving, homicide) excessive use (fatty liver, cardiomyopathy, memory impairment, cancers of the mouth, throat, and gullet, financial difficulties, divorce, homelessness, habitual convictions for drunkenness), and dependency (anxiety, epilepsy, delirium tremens, personality change, fraud).Wherever possible numbers are put on these associations, and this categorisation is very effective in bringing home the tremendous breadth and depth of problems associated with alcohol-and the report does not confuse causation and association.The report puts the total cost to Britain of alcohol misuse conservatively at li000m; a study published in the March issue of the British Journal of Addiction suggests an even higher figure of £1500m (1983 prices).'This important but brief chapter should drive the report's readers on to their own chapters anxious to see what they can do to help-for there are then detailed recommendations for each group.The longest section is that devoted to the National Health Service, but the other sections address the government, the Scottish Office, the Scottish Home and Health Department, the Scottish Education Department, the health boards, the local authorities, the educational services, the Health and Safety Executive, voluntary bodies, trade unions, employers' associations, the media, and the courts.The recommendations addressed to the NHS include a six part policy for the use of alcohol on NHS premises, and an impression of the detail of the report can be gained by noting that there are nine specific recommendations for senior hospital medical staff, seven for the professional bodies of general practitioners as well as four for the primary health care team, and 12 for area health education officers.But perhaps the one group that needs to read this report more closely than any other are the members of the Depart- ment of Health and Social Security in London, for surely England deserves such a report.The excuse that Scotland's alcohol problems are appreciably worse than those south of the border is no longer valid,'4"' and to bleat that these exercises are easier in small countries would be to admit defeat even before starting.England, Wales, and Northern Ireland should all have reports as impressive as this one from Scotland, and what all need even more is action along the lines suggested in the Scottish report.I Scottish Health EduLcation Coordinating Committee.hIealth education tn the prevention of alcohol related problems.