tbuckley/cabot-search huggingface dataset:
Nasal obstruction, a cause of sudden unexpected death?
Authors: E. Gold
Journal: JAMA (1968)

The unexpected death of a young infant previously well or ill with a minor respiratory infection occurs with considerable frequency. Sudden unexpected death (SUD) is estimated to account for 15,000 fatalities per year in the United States, or twice the number caused by congenital abnormalities. In Cleveland, with a population of approximately 1.8 million, there are about 100 such cases a year. This loss of young lives with no apparent cause has provoked numerous hypotheses which, as Shaw states in a recent communication in the<i>American Journal of Diseases of Children</i>,<sup>1</sup>"are in large part speculative and unproven." There are several observations common to most studies of the SUD syndrome; these must include the clues to its etiology and must fit any explanation: (1) Infants are usually between 2 weeks and 6 months of age, with a peak incidence at age 3 to 4 months. (2) Deaths occur in
Development of Behavioral Tests for the Assessment of Neurologic Effects of Lead in Sheep
Authors: Thomas L. Carson, Gary A. Van Gelder, George G. Karas, William B. Buck
Journal: Environmental Health Perspectives (1974)

Reports of neurologic impairment of children following recovery from acute lead encephalopathy have raised questions concerning the effects of chronic low.levellead exposure on the central nervous system.Behavioral toxicologic techniques have been employed to assess the effects of lead on the central nervous system in sheep.Mature sheep receiving daily doses of 100 mg lead/kg showed a significant decrease in performance on an auditory signal detection task.Daily oral doses of 120 and 230 mg lead/sheep for 27 weeks did not alter the performance of mature sheep on a fixed- interval schedule of reinforcement behavioral task.Prenatal exposure to maternal blood lead levels of 16 or 34 ,ug/100 ml during gestation and postnatal daily ingestion of 16, 8, 4, or 2 mg lead/kg did not alter performance of lambs on a closed-field maze task.Slowed learning was demonstrated in lambs prenatally exposed to maternal blood lead levels of 34 jug/100 ml during gestation when tested on nonspatial, two-choice visual discrimination problems at 10-15 months of age.
Pseudomelanosis Duodeni
Authors: J. A. Cantu, D. G. Adler
Journal: Endoscopy (2005)

Figure 1 A 49-year-old man with chronic renal insufficiency, hypertension, and protein S deficiency presented with jaundice 3 days after undergoing laparoscopic cholecystectomy. This was investigated by endoscopic retrograde chlolangiopancreatography, when he was found to have abnormal pigmentation of the duodenal mucosal lining (a). Closer inspection of the mucosa revealed a speckled pattern of black lesions (b), which covered virtually all of the visible duodenum. The ampulla of Vater and neighboring mucosa were devoid of these black lesions, however, contrasting with the adjacent duodenal fold, which was pigmented (c).
Phase I Trial of the Oral Poly (ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888, V) Combined Wtih Topoecan (T) and Carboplatin (C) for Adults with Relapsed and Refractory Acute Leukemias,
Authors: Keith W. Pratz, Scott H. Kaufmann, Mark R. Litzow, Jiuping Ji, Alice Chen, Michelle A Rudek, Judith E. Karp
Journal: Blood (2011)
KENTUCKY ACTS ON NOSTRUMS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical science and technology
Authors: S. Vaisrub
Journal: JAMA (1981)

The intimate juxtaposition of science and technology—both often spoken of in the same breath—is currently threatened by those who view technological advances with mistrust. Nuclear fission and genetic engineering provoke almost as much apprehension among scientists as they do among laymen. Physicians, who also share these anxieties, have a few additional ones that relate more directly to their discipline. They are concerned mainly with the effects of technology on the cost of medical care and its erosive impact on diagnostic skills and on patient-physician relationships. Today's patient may have a rendezvous with a new, costly, sophisticated diagnostic or therapeutic device before he has a meaningful interview with his physician. The interjection of new techniques into the physician-patient relationship has been resented by zealous guardians of this relationship long before technology shifted into high gear. Many of Laënnec's contemporaries opposed the stethoscope because it interposed itself between the physician's ear and
Report of Symposium: Antinuclear antibodies and their clinical significance
Authors: P Holt
Journal: Annals of the Rheumatic Diseases (1976)

Antinuclear antibodies and their clinical significance* This Symposium, jointly sponsored by the Heberden Society and the Arthritis and Rheumatism Council, was held at the Royal Postgraduate Medical School, London, on January 8, 1976.The speakers discussed the nature and source of nuclear antigens which induced an immune response, their role in immune response, methods of detection of antibodies, their role in pathogenetic mechanisms and their clinical relevance.Nuclear antigens and antigen-antibody reactions Dr. D. Stollar (Tufts University, Boston, Mass., USA) discussed the origin and types of polynucleotide antigens to which antibodies occur in systemic lupus erythematosus (SLE), stressing that DNA and RNA were not the only antigens to which antibodies are found in SLE.In general, studies of the specificity of antibodies had not confirmed or eliminated a viral infective aetiological hypothesis for the disease.Some antibodies in SLE sera are directed against purine or pyrimidine bases while others appear to be directed against the sugar-phosphate backbone; antibodies that react with double-stranded DNA (ds-DNA) may recognize the sugar-phosphate backbone of one strand of the helix (Stollar, 1973(Stollar, , 1975)).Antibody reactions with DNA occurred irrespective of whether they were of plant, viral, bacterial, or mammalian source, and this approach could not distinguish between viral or host origin of DNA.Antibodies to double-stranded RNA (ds-RNA) have a distinct specificity.The antigenic determinant may involve the backbones of both strands of the helix over a range of three or four base pairs as it does with experimentally induced antibodies (Stollar, 1973(Stollar, , 1975)).While ds-RNA may be a more charac- teristic viral form of nucleic acid, some of this polynucleotide does occur in uninfected mammalian cells, and the presence of such antibodies cannot distinguish with certainty between the viral and host forms of RNA.SLE sera also react with synthetic RNA-DNA hybrids (Talal and Gallo, 1972); how- ever, they show a less distinct specificity than do experimentally induced antihybrid antibodies (Talal and Gallo, 1972; Stollar, 1975).The hybrids could be produced by the action of the reverse transcriptase
Abstract 12613: Apurinic/apyrimidinic Endonuclease/redox Factor-1 Gene Enhances Anti-apoptotic Function of Cardiac Progenitor Cells via TAK1-Activation and Promotes Cardiac Regeneration in Myocardial Infarction
Authors: Tatsuya Aonuma, Naofumi Takehara, Keisuke Maruyama, Maki Kabara, Motoki Matsuki, Atsushi Yamauchi, Junichi Kawabe, Naoyuki Hasebe
Journal: Circulation (2015)

Introduction: Overcoming the poor survival of cell grafts is an indispensable mission in cell therapy. Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1) is known as a multifunctional enzyme to encourage cell survival, whereas the role of APE1 in cardiac cell therapy is still unknown. Hypothesis: APE1 overexpression in cardiac progenitor cells (CPC) ameliorates the effect of cardiac cell therapy. Methods: CPCs from 8-10 week-old C57BL/6 mice hearts were transfected with APE1-DsRed gene (APE1-CPC) or DsRed gene (Control [Ct]-CPC). The apoptosis induced by oxidative stress was assessed in APE1-/Ct-CPCs, and in neonatal rat cardiomyocytes (NRCM) within the co-culture system of APE1-/Ct-CPCs. Western blot analysis indicated the cellular signal to protect CPC via APE1 enzyme. To evaluate the effect of APE1 overexpression in cell therapy, we transplanted APE1-CPCs and Ct-CPCs into the mice myocardial infarction (MI) model and assessed the pathophysiological role of APE1 with functional and histological analysis. Results: Under the oxidative stress condition, APE1 overexpression inhibited the apoptosis of CPCs and accelerated TAK1 activation (Ct-CPC : APE1-CPC = 1.5±0.4 : 3.3±1.6 fold, p&lt;0.05), and consequently NfKB phosphorylation in CPCs. In the co-culture system, the apoptosis of NRCMs was inhibited with APE1-CPCs compared to that with Ct-CPCs. In vivo, in the mice MI model, the number of total CPC grafts and cardiac α-actinin-positive graft CPCs were significantly larger in APE1-CPC injected mice (APE1 mice) compared to Ct-CPC injected mice (Ct mice) at 7 days after implantation. Eventually, the left ventricular ejection fraction of APE1 mice was significantly improved compared to Ct mice (Ct mice : APE1 mice = +3.1±6.7 : +11.3±4.0%, p&lt;0.05) and was accompanied with the attenuation of fibrosis at 28 days after implantation. Conclusions: APE1 gene inhibited the apoptosis of CPCs and host cells against oxidative stress via the activation of TAK1-NFkB pathway, which is a novel insight into the stress response of APE1 enzyme. Furthermore, APE1-CPC grafts that effectively survived in the ischemic heart restored cardiac dysfunction and attenuated myocardial infarct size, and may be an innovative strategy to reinforce cardiac cell therapy.
Manufacturer's Recall of Rapid Assay Kits Based on False Positive Cryptosporidium Antigen Tests-- Wisconsin, 2001-2002
Journal: JAMA (2002)

The Wisconsin Division of Public Health and the Wisconsin State Laboratory of Hygiene (WSLH) reported that a recent cluster of cryptosporidiosis cases in a three-county area in southeastern Wisconsin was the result of false-positive tests. During December 1, 2001-February 1, 2002, approximately 30 cases of cryptosporidiosis were diagnosed at a laboratory in southeastern Wisconsin using the Becton, Dickinson, and Company (Franklin Lakes, New Jersey) ColorPAC Cryptosporidium/Giardia rapid assay (lot number 219370, expiration date 2002-06-05). Seventeen stool specimens, which were collected from 11 patients and tested positive by the rapid assay, were re-evaluated at WSLH. Six of these stool specimens were in EcoFix (Meridian Bioscience Inc., Cincinnati, Ohio), eight were in Cary-Blair transport media, and three were formalin fixed. All 17 specimens tested negative for Cryptosporidium at WSLH using the hot safranin stain and MeriFluor (Meridian Bioscience Inc., Cincinnati, Ohio) Cryptosporidium/Giardia direct fluorescent antibody kit with concentrated specimens.
American Journal of Medical Sciences, Philadelphia
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polenta publications
Authors: A. J Pelosi
Journal: BMJ (1992)

and placenta are identified in the four hours after the administration of the prostaglandin, it provides an opportunity for counselling and contraceptive advice as well as ensuring that the abortion has been completed.Ultrasound scanning is necessary only in those women in whom there is doubt as to whether the abortion is complete (<5%).Thus the number of clinic visits is no more than should be offered to a woman who has chosen vacuum aspiration.Unlike after vacuum aspiration, access to medical theatre and skilled medical and paramedical staff is required for only a small percentage (about 5%) of women after medical abortion.Though it is prudent to ensure that medical abortion is both safe and effective, it would be a pity if this choice was not made available to women because the estimates of the cost have been based on overelaborate facilities.
Man vs. Microbes.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mislocated Author
Journal: JAMA (1964)

and peritendinous changes may give rise to symptoms sug¬ gesting appendicitis or renal colic.The patients whose his¬ tories are described were thoroughly investigated to rule out visceral diseases.A feature common to all three patients was that vigorous physical activity produced the pain.Pal¬ pation of the psoas muscle elicited tenderness, in one of the patients on both sides.In the first patient, a 43-year-old woman, the pain subsided when she stopped playing bad¬ minton.In the two male patients, the pain decreased after- massage and after they avoid the movements eliciting the pain.Correct diagnosis of this condition is importan' in order to avoid an exploratory laparotomy.
Residues and Metabolites of Selected Persistent Halogenated Hydrocarbons in Blood Specimens from a General Population Survey
Authors: Robert Murphy, Clair Harvey
Journal: Environmental Health Perspectives (1985)

The National Center for Health Statistics collaborated with the National Human Monitoring Program of the U.S. Environmental Protection Agency (EPA) in a four-year study to assess the exposure of the general population to selected pesticides through analysis of blood serum and urine specimens. Specimens were collected on a national probability half-sample of persons 12-74 years of age from 64 locations across the United States comprising the sample areas in the Second National Health and Examination Survey (NHANES II) and analyzed for selected organochlorine, carbamate, chlorophenoxy and organophosphorus pesticides. Medical, nutritional and pesticide usage data are also available for each sample person. Results of the blood serum analyses indicate that the general population is being exposed to some of these types of pesticides. For selected pesticide residues, the percent quantifiable positives and median serum levels by age group are presented for three regions of the United States. Since 1970, EPA has conducted a national probability sampling of human adipose tissue. Specimens obtained on a survey design representative of the general population were analyzed for selected organochlorine pesticides and toxic chemicals. Findings from the 1979 survey also indicate exposure of the general population to some of these chemicals.
Interrelation of Bile Pigment and Hemoglobin
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHICAGO LETTER.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A critical analysis of the resource-based relative value scale
Authors: J. V. Maloney
Journal: JAMA (1991)

<h3>Background.</h3> —There is a general perception that procedural medical services are reimbursed at an inappropriately greater rate than cognitive services. By congressional mandate, the Health Care Financing Administration (HCFA) has been directed to establish a Medicare fee schedule to shift funding under a budgetneutral assumption from procedural to cognitive services. To provide a rational basis for this change, Hsiao et al (Harvard-Hsiao) developed a resource-based relative value scale (RBRVS) that equates the value of a service to the resources necessary to generate the service. <h3>Methods.</h3> —Instead of focusing on relative values and fee schedules ("price-per-unit-service"), the present study employs the standard commercial/industrial method of determining reimbursement rate (income divided by hours of labor) for 15 medical and surgical specialties. Data from independent sources are used to determine income and hours of professional effort for each of the specialties studied. Harvard-Hsiao and HCFA predicted the percent change in income for each of the specialties under the initial RBRVS and the HCFA fee schedule. The predicted income was then employed in this study to recompute reimbursement rates under the newly proposed payment systems. <h3>Results: Current Payment System.</h3> —Average annual incomes for medical and surgical specialties are $124500 and $176600, respectively, a 42% difference (<i>P</i>=.03). Average weekly work hours (nominal hours, as adjusted for overtime) for medical and surgical specialties are 70.6 and 87.8, respectively (<i>P</i>=.005). Average hourly reimbursement rates for medical ($33.90) and surgical ($38.80) specialties are not substantially different (<i>P</i>, not significant). The difference in annual income is explained by the 17.2 hours per week of additional work hours by surgeons. The erroneous perception that procedurists are reimbursed at a higher rate than cognitive practitioners likely arises from differences in billing methods by which surgeons shift charges for cognitive work hours to the 18% of their time spent in the operating room. <h3>Results: Proposed RBRVS and HCFA Payment System.</h3> —The income of all specialties is equalized about a mean of $132 500 (±$21 400 [1 SD]) by varying reimbursement rates in such a way that the effect of working hours is fully discounted. Reimbursement rates under the proposed payment system make no recognition of the hours of professional effort, postgraduate specialty training, or putative differences in the nature of the physician's work. <h3>Conclusion.</h3> —The RBRVS, and the HCFA fee schedule to the extent that it is based on that scale, are inappropriate bases for the reform of the physician reimbursement system. (<i>JAMA</i>. 1991;266:3453-3458)
Correction
Journal: BMJ (1962)

ANY QUESTIONS?worth trying a phenothiazine such as promazine in doses of 50 mg.three times daily.If at certain periods during the day this produces undue drowsiness a change should be made to the longer-acting promazineresinate, 50-200 mg.twice daily.'But phenothiazines with marked extrapyramidal side-effects should be avoided; these include perphenazine and trifluoperazine.If anxiety and depression are marked features some of the newer antidepressant drugs are effective tranquillizers.2Phenelzine, which is an amine oxidase inhibitor, may be tried in a dose of 30 mg. twice a day.It should be recognized, however, that the relief of depression may be less satisfactory if there is considerable arteriosclerotic brain damage.To date, muscle-relaxant drugs have not proved of value in reducing the spasticity of neurological disorders.But if the clinical picture is that of arteriosclerotic Parkinsonism, in which spasticity of the legs is often a marked feature, benzhexol in gradually increasing doses up to a total of 20 mg. per day or chlorphenoxamine up to 450 mg. per day should be tried.