tbuckley/cabot-search huggingface dataset:
Sexual Behavior in Japanese Quail as a Test End Point for Endocrine Disruption: Effects of in Ovo Exposure to Ethinylestradiol and Diethylstilbestrol
Authors: Krister Halldin, Cecilia Berg, Ingvar Brandt, Bjorn Brunstrom
Journal: Environmental Health Perspectives (1999)

Chemicals having a capacity to disturb the endocrine system have attracted considerable interest during recent years. There is a shortage of well-characterized in vivo tests with which to study such disturbances in different classes of vertebrates. In the present study, test end points related to reproduction in the Japanese quail were used to examine the estrogenic activity of chemicals. The synthetic estrogens ethinylestradiol (EE(2)) and diethylstilbestrol (DES), used as model compounds, were injected into the yolk of embryonated eggs. After the birds had been raised to sexual maturity, we examined sexual behavior, plasma testosterone concentrations, and testis morphology in adult males. The lowest doses resulting in a significantly depressed male sexual behavior were 6 ng/g egg for EE(2) and 19 ng/g egg for DES. Testis weight asymmetry was increased at 6 ng EE(2)/g egg, but DES had no effect at any treatment level. The area of the androgen-dependent cloacal gland was significantly reduced at 57 ng DES/g egg. No effects on plasma testosterone concentration or body weight following exposure to EE(2) or DES were observed at any dose level. Depressed male sexual behavior was the most sensitive of the end points studied, and we suggest that this ecologically relevant end point be included in avian in vivo testing for neuroendocrine disruptors.
OP0237 Lung ultrasound for the screening of interstitial lung disease in very early systemic sclerosis
Authors: L. Gargani, T. Barskova, M.L. Conforti, S. Guiducci, C. Bruni, A. Moggi Pignone, E. Picano, M. Matucci Cerinic
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Many systemic sclerosis (SSc) patients develop interstitial lung disease (ILD) during the course of the disease. Promising data have recently shown that lung ultrasound (LUS) is able to detect ILD by the evaluation of B-lines, the sonographic sign of lung interstitial syndrome. <h3>Objectives</h3> To evaluate whether B-lines assessed by LUS are reliable in the screening of ILD in patients with SSc. <h3>Methods</h3> Fifty consecutive SSc patients (47 females) who underwent a clinically-driven chest high resolution computed tomography (HRCT) were evaluated by LUS for detection of B-lines. Among them, 27 patients fulfilled the criteria for a Very Early Diagnosis Of SSc (VEDOSS). <h3>Results</h3> At least mild ILD was present at HRCT in 76% of the total population and in 70% of the VEDOSS population. A significant difference in B-lines number was found in patients with and without ILD on HRCT (62±54 vs 11±10; p&lt;.0001), with a concordance rate of 88%. All discordant cases were false positive at LUS. When considering only the VEDOSS population, the concordance rate between the two exams was 89%, with a sensitivity of 100%, a negative predictive value of 100%, specificity of 50% and positive predictive value of 87.5%. <h3>Conclusions</h3> ILD appears very early in SSc patients. Presence of B-lines at LUS examination correlates with ILD at HRCT. LUS is very sensitive to detect early ILD even in patients with very early diagnosis of SSc. The use of LUS as a screening tool for ILD seems feasible to guide further investigation with HRCT. <h3>Disclosure of Interest</h3> None Declared
Rubella Vaccine
Journal: Annals of Internal Medicine (1978)

Diagnosis and Treatment1 April 1978Rubella VaccineRecommendation of the Public Health Service Advisory Committee on Immunization PracticesAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-543 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractRubella infection may be subclinical or overlooked because of the nonspecificity of its most frequent manifestations. Joint involvement is most frequent in women but can occur in men and children. The most serious complication is induction of fetal anomalies in infected pregnant women. This paper reviews the proper use of live rubella virus vaccine for prophylactive immunization and the postexposure treatment with immune serum globulin for modification or suppression of symptoms.Selected Bibliography1. COOPERKRUGMAN LS: The rubella problem. DM:3-38, 1969 Google Scholar2. FARQUHAR J: Follow-up on rubella vaccinations and experience with subclinical reinfection. J Pediatr 81:460-465, 1972 CrossrefMedlineGoogle Scholar3. HAYDENMODLINWITTE GJJ: Current status of rubella in the United States, 1969-1975. J Infect Dis 135:337, 1977 CrossrefMedlineGoogle Scholar4. HERRMANNHALSTEADBRANDLING-BENNETTWITTEWEIBENGAEDDINS KSAJND: Rubella immunization. Persistence of antibody 4 years after a large-scale field trial. JAMA 235:2201-2204, 1976 CrossrefMedlineGoogle Scholar5. HORSTMANN D: Controlling rubella: problems and perspectives. Ann Intern Med 83:412-417, 1975 LinkGoogle Scholar6. KRUGMAN S: Present status of measles and rubella immunization in the United States: a medical progress report. J Pediatr 90:1, 1977 CrossrefMedlineGoogle Scholar7. MARYMONTHERRMANN JK: Rubella in pregnancy: review of current problems. Postgrad Med 56:167-172, 1974 CrossrefMedlineGoogle Scholar8. MODLINBRADLING-BENNETTWITTECAMPBELLMEYERS JAJCJ: A review of 5 years' experience with rubella vaccine in the United States. Pediatrics 55:20-29, 1975 MedlineGoogle Scholar9. MODLINHERRMANNBRANDLING-BENNETTEDDINSHAYDEN JKADG: Risk of congenital abnormality after inadvertent rubella vaccination of pregnant women. N Engl J Med 294:972-974, 1976 CrossrefMedlineGoogle Scholar10. WEIBELBUYNAKMCLEANHILLEMAN REAM: Long-term follow-up for immunity after monovalent or combined live measles, mumps, and rubella virus vaccines. Pediatrics 56:380-387, 1975 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: ▸From the Center for Disease Control, U.S. Department of Health, Education, and Welfare; Atlanta, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReactions to Rubella Immunizations in Adult Clients of an Employee Health SettingDrug Information Analysis ServiceImmunization for adults 1 April 1978Volume 88, Issue 4Page: 543-545KeywordsChildrenImmune serum globulinPregnancyPregnancy complicationsRubellaRubella vaccineVaccines ePublished: 1 December 2008 Issue Published: 1 April 1978 PDF downloadLoading ...
Lessons on Tuberculosis and Consumption for the Household. Showing How to Prevent Tuberculosis. How to Recognize Its First Symptoms, How to Win Back Health.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glossary of Cardiologic Terms Related to Physical Diagnosis and History
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intensive smoking cessation efforts cost-effective
Authors: C. Marwick
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Nasal Organs and Naso-pharynx.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MUTATION AS A CAUSE OF DISEASE
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Judgement call
Authors: Gregory A Petsko
Journal: Genome biology (2003)

about information technology, who broke the story, at least in my town.In a column on 3 February this year, he recounted what happened to the Litchfield brothers, a pair of British computer security experts whose company, Next Generation Software, specializes in developing programs to help businesses and governments defend against computer viruses and hackers.Mark and David Litchfield are experts at finding weaknesses in widely used software, and last year they found a bug in Microsoft's SQL Server database software.To establish that the bug could be used to cripple computer networks, David Litchfield wrote an exploit program, a kind of dummy virus.The existence of the bug, a buffer overflow problem, was then communicated to Microsoft, which published a fix in July.Other security experts had already been asking for copies of the exploit program so they could test their own systems and become familiar with this new potential method of attacking networks, and David Litchfield eventually released his code, but only after the patch to fix the program had been published.He thought, quite reasonably, that once the fix was available, SQL Server users would no longer be vulnerable.
Canadian J Physiology &amp;amp; Pharmacol, Ottawa
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NATIONAL ASSOCIATION FOR THE FEEBLE-MINDED
Journal: BMJ (1908)

The National Association for the Feeble-minded held a conference at Denison House on November 8, which, in spite of the weather, was attended by many of those who feel a deep interest in this peculiarly unfortunate class.Sir Wil- liam Chance presided.The tone of the whole conference was set in the first paper, by Mrs. Hume Pinsent, on " The Importance of After-care Committees Wherever Special Schools Exist."The whole question of the feeble-minded
Washington, D. C.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reduced serum levels of immunoreactive erythropoietin in patients with cirrhosis and chronic anemia
Authors: Massimo Siciliano, Daniele Tomasello, Alessandro Milani, Bianca Maria Ricerca, Sergio Storti, Lodovico Rossi
Journal: Hepatology (1995)

Chronic anemia is frequently observed in patients affected by cirrhosis. To investigate the possible role of erythropoietin (Epo) in the pathogenesis of anemia in cirrhosis, we measured the immunoreactive Epo levels and the respective hemoglobin (Hb) concentrations in 48 anemic and nonanemic cirrhotic patients and in a control group of healthy subjects and patients with iron-deficiency anemia. Epo concentrations were determined in serum using a sensitive enzyme immunoassay. The regression curve between Epo values and Hb concentrations showed a significant inverse exponential trend both in cirrhotic patients (r = −.55; P < .0001) and controls (r = −.92; P < .0001). In a semilogarithmic plot, the line slope obtained in cirrhotic patients was significantly lower (P < .005) than that of controls, suggesting a blunt Epo response to anemia in cirrhosis. Moreover, covariance analysis showed that the Epo levels for a given degree of anemia were furtherly reduced in the patients with a more severe disease, suggesting a close relation between cirrhosis and the mechanisms involved in the derangement of the Epo feedback system. Finally, the Epo concentrations measured in the cirrhotic patients without anemia did not significantly differ from Epo values obtained in healthy subjects. An impaired Epo response may play a role in maintaining low Hb concentrations in cirrhotic patients with anemia. However, the evidence of a residual Epo response to anemia in cirrhosis and the presence of normal basal Epo levels in nonanemic cirrhotic patients do not support an inadequate Epo secretion as one of the primary causes of anemia in cirrhosis. (HEPATOLOGY 1995;22:1132–1135.).
Abstract 3539: Low Inflammatory Activity Evidenced By hsCRP Predicts A Benefit From Clopidogrel Treatment In Patients With High Risk For Cardiovascular Events. - A Substudy From The CHARISMA Trial
Authors: Michael W Weber, Christian W Hamm, Deepak L Bhatt, Eric J Topol
Journal: Circulation (2007)

Aims We investigated the impact of clopidogrel treatment on the inflammatory activity as evidenced by a change of hsCRP levels in a broad population of high risk for atherothrombotic events. Further, the prediction of hsCRP levels for a treatment benefit of clopidogrel was explored. Methods This study included 8021 patients with overt atherosclerotic disease or multiple cardiovascular risk factors enrolled in the CHARISMA trial. Patients were randomized either to clopidogrel plus aspirin or placebo plus aspirin. HsCRP was measured at study entry and at study termination (median 28 months). The predefined primary endpoints were myocardial infarction, stroke and death from cardiovascular causes. Results There was a stepwise increase in the event rate of the combined primary endpoint with increasing quartiles of hsCRP (4.0%, 6.1%, 7.4% and 8.7% in the highest quartile). In both treatment groups the changes of hsCRP levels over time were identical. In patients with low hsCRP levels (&lt;3 mg/l) clopidogrel treatment was associated with a lower event rate as compared to placebo (4.0% vs. 6.0%, Log-rank p=0.005). In contrast no treatment effect could be observed in patients with high hsCRP levels (8.1% vs. 8.0%, ns). Conclusions Surpisingly, the reduction of cardiovascular events by antiplatelet treatment with clopidogrel occurred in patients with low levels of hs-CRP
Studies illuminate hazards of ingested radiation
Authors: B. Merz
Journal: JAMA (1987)

DIP... PAINT... LICK the brush. The rhythmic sequence was second nature to those known as luminators during the 1920s. Their task was simple—to apply radium paint to the tiny numerals encircling watch dials. Their occupational hazards were manifold—osteomyelitis, aplastic anemia, osteosarcoma, and mastoid carcinoma. Dial painting required a deft hand and a finely pointed brush. While the first attribute may have been hereditary, the second was easily acquired. All it took to keep a brush pointed was a quick touch to the lips or tongue. "Lip tipping" passed particles of the sticky paint to the teeth and tongue; it also transferred from 3 to 43 μg of radioactive substances each day. Thus, in a few years' time luminators could easily have swallowed 5 mg or more, at least 1 mg of which would be deposited in their bones, spleen, and liver, where it would remain, emitting a steady stream of