tbuckley/cabot-search huggingface dataset:
Transfer of Tolbutamide Across the Human Placenta
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 209: Kawasaki Disease In Infants. Experience in a Third Level Facility in Mexico City
Authors: ANA I RAMIREZ-PEREA, LUIS M GARRIDO-GARCIA
Journal: Circulation (2015)

Background: Kawasaki disease (KD) is an acute febrile vasculitis of unknown origin. KD represents the most common cause of acquired heart disease in children in developed countries. Worldwide KD is uncommon in infants (younger than 3 months of age), and in Mexico there are few reports of KD in this group of age. Objective: To describe the clinical features, laboratory parameters, the incidence of coronary aneurysms, treatment employed and the outcome of infants with KD in a third level facility in Mexico City Methods: A retrospective and descriptive study was performed on children younger than 3 months of age with KD from August 1995 to August 2014. We analyzed gender, age, clinical manifestations, hemoglobin levels, leucocyte count, platelet count, ESR, CRP, albumin, sodium, potassium, AST, ASL, time from the onset of the symptoms to diagnosis, treatment used, the development of CAA and outcome in the acute phase of the disease. Results: Eight infants were diagnosed with KD during the study period. The median age at diagnosis was 2.5 months (range 2-3 months). Five patients were male (62.5%). The median from the onset of the clinical manifestations to diagnosis of KD was 14 days (range 4 to 26 days). All patients received medical consultations (range 1 to 7) prior to diagnosis. An incomplete form of KD was present in 4 patients. Five patients (62.5%) received IVIG. Four patients (40%) received steroids and low dose aspirin. Five of our patients developed coronary aneurysms, all of them were categorized as giant aneurysms (Z-Score &gt; 10); one of these patients died of cardiogenic shock in the acute phase of the disease. Conclusions: In Latin American countries are few reports of KD in infants. We present our experience in infants with KD. Near two thirds of our patients developed coronary aneurisms; most of the patients with coronary aneurisms were associated with late diagnosis and therefore late onset treatment.
Research Perspectives concerning Asbestos Minerals and Their Effects on Biological Systems
Authors: Arthur M. Langer
Journal: Environmental Health Perspectives (1974)

The interaction of asbestos minerals with biological materials is under intensive investigation throughout the world today. Physical scientists should be responsible for the selection of fibers, and their varietal types, for biological studies; they should characterize these experimental materials physically and chemically to the level of sophistication which currently exists in their fields; they should develop definitive assay methods to monitor changes in such characteristics after biological residence; they should actively participate in the formulation of theories or mechanisms of particle interaction in biological systems.Physical scientists should begin the characterization of minerals in the environment and the determination of ambient fiber levels in air and potable water supplies. Such characterization of the environment requires standardized instrumentation and preparation techniques. Acquisition of data in numbers large enough to achieve statistical significance requires the development of automated counting strategies. Instrumentation and software have yet to be developed. The training of physical scientists in environmental areas is lagging behind current national needs and must be accelerated.
The Dueling Diagnoses of Darwin
Authors: Gerald M. FitzGibbon
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Barloon and Noyes<sup>1</sup>suggest that Charles Darwin's anxiety neurosis might more specifically be classified as panic disorder with agoraphobia. It is an attractive hypothesis. However, their opinion that the illness may well have facilitated completion of Darwin's work is not original and invites comment. In his 1974 book, Pickering<sup>2</sup>examined creative genius and discussed the close link between mental illness and the work of 6 famous people. These links differed distinctly in their nature. A thoroughly researched consideration of the life and work of Darwin was the starting point for his study. He considered, as also in the case of Florence Nightingale, the role of emotional illness in providing the social withdrawal essential to intense and prolonged intellectual activity. The book was acclaimed and reprinted<sup>3</sup>in the United States. References to it are readily accessible in the medical literature, as, for instance, in the article<sup>4</sup>by
Sequential trials
Authors: P. Sedgwick
Journal: BMJ (2012)

Researchers investigated whether “collaborative requesting” increased consent rates for organ donation from relatives of patients meeting criteria for brain stem death. A randomised controlled trial using a sequential design was performed. Collaborative requesting is when the patient’s clinician and a donor transplant coordinator (organ procurement officer) make a joint request for a donation. The control intervention was the routine request by the clinical team. The primary outcome was consent for organ donation. In total, 201 relatives were recruited from intensive care units. It was reported that collaborative requesting did not significantly affect consent rates when compared with routine requesting.1 Which of the following statements, if any, are true?
Abstracts
Journal: Journal of Clinical Investigation (1972)

There is growing evidence that "nonspecific" diarrhea in man may be caused by enterotoxin-producing strains of Escherichia coli.We studied the pathophysiology of such diarrhea in the dog using a whole cell lysate preparation of E. coli 410G, a strain isolated from the small bowel of a patient with acute diarrhea.Chronic Thiry-Vella loops of jejunum and ileum were exposed to an isotonic solution containing lysate.Net secretion of H20, Na+, and K+, and HCOistarted 20 min after exposure and peaked during the second hour postchallenge; the fluid output rapidly diminished during the subsequent 2 hr in both jejunum and ileum.Secretion was somewhat greater in the ileum than in the jejunum.Mean control and peak postchallenge values respectively were for jejunum, H20, 0.13 and -0.17 ml/ min; Na+, 0.022 and -0.033 mEq/min; and for ileum, H20, 0.21 and -0.31 ml/min; Nae, 0.030 and -0.57mEq/ min.These differences were all significant as judged by the paired T test (P < 0.01).Perfusion of the colon with the toxin preparation showed no effect on salt and water trans- port.Thus, E. coli toxin is similar to cholera toxin in that the fluid effluent appears to originate in the small bowel.However, fluid secretion with E. coli peaked earlier and was of shorter duration than with cholera.This copious, but short-lived secretion is typical of the clinical picture of nonspecific diarrhea.The canine model should be useful in further studying the mechanisms of diarrheogenic toxins associated with nonspecific diarrhea.
BOOK REVIEWS
Authors: I. T. Magrath
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Immunological Approaches to the Classification and Management of Lymphomas and Leukemias. John M. Bennett Kenneth A. Foon eds.Dordrecht, The Netherlands: Martinus Nijhoff Publishers, 1988; 304 pp. $89.95. IAN T. Magrath IAN T. Magrath Pediatrics Branch National Cancer InstituteBuilding 10, Room 13N240 Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 4, 15 February 1989, Pages 307–309, https://doi.org/10.1093/jnci/81.4.307-a Published: 15 February 1989
Mind and Madness in Ancient Greece: The Classical Roots of Modern Psychiatry
Authors: J. C. N.
Journal: American Journal of Psychiatry (1980)

De Lacy's comments on John Caius also require slight amplification.Where and how Caius obtained his manuscript of PHP is unknown: Muller calculated that it was in 1543, hinting at Italy and even Florence as the source.De Lacy's suggestion, p.31, of Paris is unlikely, especially since, as far as is known, Caius travelled to England from Italy via the Rhine (cf.De libris propriis.p. 102 f., De pronunciatione, p. 19, ed.Roberts), with a very brief stay in northern France.The annotations in the Cambridge University Library copy of his edition and first version of Book I, Basle 1544, class- mark Adv.d. 3. 1, are indubitably in Caius' own hand, for several of the changes indicated to the Latin translation were incorporated in
Gastric hypothermia for duodenal ulcer. A long-term controlled study
Authors: W. R. Harrell
Journal: JAMA (1967)

Fifty-two patients with active duodenal ulcer were divided randomly into two groups. The control group was "sham frozen" while the hypothermia group received a standard gastric freezing procedure. All patients were followed for a minimum of 18 months. Both groups experienced symptomatic improvement. The degree and duration of symptomatic improvement was greater in the hypothermia group, and the results were statistically significant at three and six months. Depression of basal acid secretion was transient, but significant depression of the maximum acid output was observed following hypothermia, and this lasted six months. However, there was no correlation between clinical improvement and altered gastric secretory function. While the benefits of gastric hypothermia appear definite, our observations indicate that the brief duration of clinical improvement does not justify the use of this method.
Shakespearean Medicine
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death
Authors: Roger J. Lewis
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A comprehensive census of horizontal gene transfers from prokaryotes to unikonts
Authors: Pere Puigbò, Sergei Mekhedov, Yuri I Wolf, Eugene V Koonin
Journal: Genome biology (2011)

Deep exome resequencing is a powerful approach for delineating patterns of protein-coding variation among genes, pathways, individuals and populations.We analyzed exome data from 2,440 individuals of European and African ancestry as part of the National Heart, Lung, and Blood Institute's Exome Project, the aim of which is to discover novel genes and mechanisms that contribute to heart, lung and blood disorders.Each exome was sequenced to a mean coverage of 116×, allowing detailed inferences about the population genomic patterns of both common variation and rare coding variation.We identifi ed more than 500,000 single nucleotide variations, the majority of which were novel and rare (76% of variants had a minor allele frequency of less than 0.1%), refl ecting the recent dramatic increase in the size of the human population.The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and purifying selection in shaping patterns of proteincoding variation and the diff erential signatures of population structure from rare and common variation.This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health.
Impact of atrial fibrillation on neurohormonal status and systolic pressure variability Maria V. Pitzalis, Francesco Massari, Massimo Grimaldi, Massimo Iacoviello, Filippo Mastropasqua, Giovanni Luzzi, Brian Rizzon, Vito Vulpis, Paolo Rizzon. Institute of Cardiology - University of Bari, Bari, Italy, Cardiology Dept. ?S. Maugeri? Foundation, Cassano Murge, Italy
Journal: Journal of the American College of Cardiology (2001)
Computers Could Speed Processing of Hospital Patients' Lab Tests
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coeliac disease
Authors: C C Booth
Journal: Gut (1984)

only a very limited extent in patients with untreated coeliac disease and only to a limited extent by patients treated for as short a time as three to eight months.The lactose would therefore remain osmotically active in the small intestinal lumen in coeliac patients, decreasing transit time and reducing the absorption of the test substances, while in normal subjects, it is readily hydrolysed and quickly absorbed.Thirdly, these same workers have themselves noted that cellobiose is itself partially hydrolysed and others have presented experimental data that show that the use of mannitol is questionable.6These factors may very well explain the apparent discrepancy between our results and theirs.Drs Hamilton, Cobden, and Axon should be fully aware that the sensitivity of their test is low in comparison with the 51 Cr EDTA absorption test, and with our recently described in vitro test.Numerous communications concerning the use of various sugar ratios attests to their lack of specificity.'2
A Hundred Years Ago
Authors: None R. F.
Journal: New England Journal of Medicine (1946)

Strange stories are related in the papers of a wonderful preparation in this city, by administering which a patient is affected just long enough and just powerfully enough to undergo a surgical operation without pain. — Benjamin Waterhouse, M.D., died recently at the patriarchal age of ninety-two at his residence in Cambridge. During the active part of his life very few physicians have held a more conspicuous place in the public observation. A lecture which he delivered about 1805 to the Harvard undergraduates on the custom of smoking cigars is supposed to have had great influence in whatever diminution of . . .
HIV Seroprevalence Among Adults Treated for Cardiac Arrest Before Reaching a Medical Facility
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Syndromic Validity of Apathy in Alzheimer's Disease
Authors: S. E. Starkstein
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: The study examined the usefulness and clinical correlates of specific diagnostic criteria for apathy in Alzheimer’s disease. Whereas apathy is a frequent behavioral change in patients with Alzheimer’s disease, the lack of standardized diagnostic criteria may explain the wide discrepancies in estimates of the frequency and demographic and clinical correlates of apathy. METHOD: A consecutive series of 319 patients who met the criteria for probable Alzheimer’s disease established by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association, 117 patients who met the DSM-IV criteria for depression without dementia, and 36 healthy individuals were assessed with a structured psychiatric interview. On the basis of modified Marin’s criteria for apathy, they were classified into groups with or without apathy. RESULTS: Apathy was diagnosed in 37% of the 319 Alzheimer’s disease patients, compared to none of the healthy comparison subjects. In 24% of the Alzheimer’s disease sample, apathy coexisted with either dysthymic disorder or major depressive disorder, whereas 13% had apathy without depression. Apathy was diagnosed in 32% of the depressed nondemented patients, mostly in those with major depressive disorder. Apathy in Alzheimer’s disease was significantly associated with severe impairments in activities of daily living and cognitive functions, older age, and poor awareness of behavioral and cognitive changes. CONCLUSIONS: This study provides partial validation of specific clinical criteria for apathy in Alzheimer’s disease.
Effects of prophylactic lidocaine in suspected acute myocardial infarction. An overview of results from the randomized, controlled trials
Authors: S. MacMahon
Journal: JAMA (1988)

The effects of prophylactic lidocaine hydrochloride on early ventricular fibrillation and death in patients with suspected acute myocardial infarction were investigated in an overview of 14 randomized trials. During follow-up intervals of one to four hours in the trials of intramuscular lidocaine infusion (6961 patients) and 24 to 48 hours in the trials of intravenous lidocaine injection (2194 patients), a total of 103 cases of ventricular fibrillation and 137 deaths were recorded. Overall, allocation to lidocaine was associated with a reduction in the odds of ventricular fibrillation of about one third, with a 95% confidence interval that ranged from a 3% to a 56% reduction. There was no evidence of any beneficial effect on early mortality; indeed, the odds of early death were about one third greater among patients allocated lidocaine, though this difference was not statistically significant (95% confidence interval, 2% reduction to 95% increase). Because of the small numbers of reported events, the short follow-up periods, and the unavailability of data for some specific causes of death, even an overview of all the trial results does not provide good evidence as to whether prophylactic lidocaine is likely to be helpful or harmful. To answer this question reliably, future trials will need to involve large numbers of patients and prolonged follow-up. (<i>JAMA</i>1988;260:1910-1916)
Treatment for early syphilis and reactivity of serologic tests
Authors: A. L. Schroeter
Journal: JAMA (1972)

The Venereal Disease Branch, Center for Disease Control, in a cooperative study has reevaluated the comparative efficacy of antibiotic schedules for the treatment of early syphilis in 586 patients. All parenteral penicillin, tetracycline, and erythromycin treatment schedules recommended by the Public Health Service were studied. Erythromycin in base form, 20 gm, was given in a divided-dose schedule over a ten-day period. Subsequently, the dose of erythromycin had to be raised to 30 gm because of a high failure rate. All penicillin schedules tested showed a satisfactory cure rate with a cumulative re-treatment rate of only 10% in the 24-month observation period. The 30-gm schedule of erythromycin base proved as effective as tetracycline and penicillin G.