tbuckley/cabot-search huggingface dataset:
Highlights
Authors: J Blackford, R Davidson, J Scott
Journal: JAMA Psychiatry (2017)

Posttraumatic stress disorder emerges after a traumatic event, but the development of symptoms remains poorly understood.Bryant and coauthors used network analysis to study the network symptom associations of posttraumatic stress disorder in 1138 patients during admission to a trauma hospital and 12 months after injury.Symptoms were strongly connected during the acute phase, with reexperiencing symptoms at the center of the network.After 12 months, fear circuitry and dysphoric symptoms began to emerge.In an editorial, McNally discusses the value of network analysis for the study of psychiatric disorders.
Genetics and Molecular Biology of Ionic Channels in Drosophila
Authors: M A Tanouye,, C A Kamb,, L E Iverson, and, L Salkoff
Journal: Annual Review of Neuroscience (1986)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Functional and ultrastructural features of ethanol/bile salts interaction in the isolated perfused rat liver
Authors: D ALVARO
Journal: Hepatology (1995)

We investigated whether bile salts (BS) with different hydrophobic-hydrophilic properties interact with ethanol on bile secretion, enzyme (aspartate transaminase [AST], lactate dehydrogenase [LDH]) release in the perfusate, liver ultrastructure, and vesicular exocytosis in the isolated perfused rat liver. Ethanol (0.1 or 1%) promoted a rapid decrease of bile flow and BS secretion in livers perfused with taurocholate (TCA), the physiologic BS in the rat (−28% decrease of baseline values with 0.1% and −34% with 1% ethanol). The inhibitory effect of ethanol on bile flow and BS secretion was significantly (P < .02) attenuated by perfusing liver with the hydrophilic BS, tauroursodeoxycholate (TUDCA), and it was exacerbated (P < .02) by perfusion with the hydrophobic BS, taurodeoxycholate (TDCA). The release of AST and LDH in the perfusate was unaffected by 0.1% ethanol, but increased threefold to fivefold by 1% ethanol in TCA-perfused livers. This cytolitic effect of ethanol was not observed in TUDCA-perfused livers, but it was enhanced (P < .03) by perfusion with TDCA. No ultrastructural abnormalities were found in either TCA- or TUDCA-perfused livers, with or without 1% ethanol. Only minimal changes were found in livers perfused with TDCA alone, but, in the presence of TDCA, 1% ethanol induces marked mitochondrial damage. The biliary excretion of the fluid phase marker horseradish peroxidase was inhibited by ethanol, an effect reversed by TUDCA (P < .02) and exacerbated by TDCA (P < .04). In conclusion, this study demonstrates that hydrophilic BS such as TUDCA counteract the inhibitory effect of ethanol on bile secretion and vesicular exocytosis as well as the ethanol-induced cytolitic effect in the isolated perfused rat liver. In the presence of hydrophobic BS such as TDCA, the exposure to ethanol promotes a marked inhibition of bile secretion and vesicular exocytosis as well as prominent mitochondrial damage. (HEPATOLOGY 1995; 21:1120–1129.)
Target for Tocopherol
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Was der praktische Arzt über Vitamine wissen soll
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The federal regulation of prescription drug advertising and promotion
Authors: D. A. Kessler
Journal: JAMA (1990)

Prescription drug advertising has been regulated by the Food and Drug Administration since 1962. In the past decade, pharmaceutical companies have employed new communication mechanisms to reach physicians and, with increasing frequency, consumers. Examples of physician-oriented promotional activities are medical symposia and teleconferences. Consumer-oriented efforts include press conferences, use of celebrity spokespeople, and direct-to-consumer advertising. The Food and Drug Administration has asserted its legal jurisdiction over these nontraditional promotional activities and is regulating them on a case-by-case basis. As nontraditional promotional efforts become more prevalent, the Food and Drug Administration's regulatory framework must be able to meet the challenges of a changing environment. (<i>JAMA</i>. 1990;264:2409-2415)
The four horsemen of the apocalypse. Study of academic medical center governance
Authors: R. G. Petersdorf
Journal: JAMA (1982)

Governance of academic medical centers is in a process of change. This essay reviews some of the historical factors that have affected the present status of academic medical center governance and describes the functions of the four individuals who are most involved in the operation of academic medical centers: vice-presidents for health affairs, deans of schools of medicine, department chairmen, and hospital directors. The relationships between these four individuals are analyzed, and points of conflict are identified. Some suggestions about how these individuals can work together more effectively are made. (<i>JAMA</i>1982;247:1153-1161)
Intravascular sonotherapy in human coronary arteries: First results of a feasibility trial Richard E. Kuntz, Jeffrey W. Moses, Alexander A. C. Abizaid, Nicholas A. F. Chronos, Michael R. Mooney, Reginald I. Low, Alan C. Yeung, Douglas W. Losordo, Joseph P. Carrozza, Neil J. Weissman, Jeffrey J. Popma, Patrick W. Serruys. Brigham &amp; Women's Hospital, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
Aortoduodenal Fistula Secondary to Metastatic Carcinoma
Authors: Steven R. Geary
Journal: JAMA (1976)

AORTODUODENAL fistula is an uncommon but well-recognized pathologic entity. The majority of cases are caused by rupture of an aortic aneurysm or are complications of aortic reconstructive surgery. Carcinoma, either primary or metastatic, is a distinctly unusual cause. Because of the lesion's infrequency and its accompanying grave clinical condition, few patients with gastrointestinal hemorrhage caused by aortoduodenal fistula have been studied angiographically. The following is a case in which the fistula and its cause were detected by angiography. <h3>Report of a Case</h3> A 36-year-old woman had an exophytic lesion of the uterine cervix in September 1971. Results of a physical examination were otherwise normal. Hemogram, liver chemistry values, chest x-ray film, intravenous urogram, barium enema examination, sigmoidoscopy, and cystoscopy were normal. A biopsy specimen showed invasive, well-differentiated carcinoma, representing stage IB tumor. The patient received 4,000 rads of external radiation to the pelvis, followed by brief readmissions for intracavitary radiation
THE ILIOSACRAL JOINT
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VARIATIONS IN THE ANTISCORBUTIC POTENCY OF MILK
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Localized xanthomas in lymphedema praecox
Authors: K. R. Woolling
Journal: JAMA (1970)

A girl, aged 14, had an extensive normolipemic xanthomatous eruption develop in one leg and foot, soon after the onset of lymphedema in the same limb. When the edema was reduced by treatment, the xanthomatous eruption greatly improved. It was speculated whether mechanical stretching of the skin might have been a factor contributing to the localized development of xanthomatosis in a xanthoma-prone individual.
Abstract 1919: Characterization of URST1 as a prognostic biomarker and therapeutic target for oral cancer
Authors: Atsushii Takano, Yohei Miyagi, Yataro Daigo
Journal: Cancer Research (2018)

Abstract Oral cancer shows a high mortality rate, and its incidence is increasing gradually worldwide. Current therapies for oral cancer include surgery, radiotherapy, and chemotherapy, however, local and regional recurrences account for up to 90% of treatment failures after surgery and radiotherapy. Therefore, next generation biomarkers and therapeutic strategies for oral cancer are eagerly awaited. To identify biomarkers and therapeutic targets for oral cancer, we screened genes that overexpressed in the majority of oral cancers by using our original gene expression profile database and identified up-regulated in solid tumor 1 (URST1) as a candidate. Immunohistochemical staining showed that URST1 expression was observed in the majority of oral cancer in 64 of 96 (67%) that had received curative surgery. URST1 expression was associated with poor prognosis for oral cancer patients (P = 0.032 by log-rank test). Reduction of URST1 expression by siRNAs against URST1 (si-URST1) significantly suppressed growth of oral cancer cells. Flow cytometric analysis revealed that si-URST1 increased the population of cancer cells at G2/M. In addition, exposure of cancer cells to selective URST1 inhibitor suppressed the growth of oral cancer cells. These data indicate that URST1 is a possible prognostic biomarker and therapeutic target for oral cancer. Citation Format: Atsushii Takano, Yohei Miyagi, Yataro Daigo. Characterization of URST1 as a prognostic biomarker and therapeutic target for oral cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1919.
Alcohol use and hepatitis C
Authors: Marion G. Peters, Norah A. Terrault
Journal: Hepatology (2002)

Excess alcohol consumption can worsen the course and outcome of chronic hepatitis C. It is important to distinguish between alcohol abuse, which must be treated on its own merits, and the effect of alcohol use on progression, severity, and treatment of hepatitis C. Most studies on the effects of alcohol on hepatitis C have focused on patients with high levels of daily alcohol intake. Indeed, the adverse effects of light and moderate amounts of alcohol intake on hepatitis C virus (HCV) infection have not been clearly shown, and only limited studies have been performed. Sex differences exist in the effect of alcohol on fibrosis as well as on the severity of hepatitis C. Alcohol use has been reported to be associated with lower responses to therapy and, in some studies, higher HCV RNA levels and increased HCV quasi-species. Few studies address the treatment of hepatitis C in the alcoholic individual or determine the effect of continued light or moderate alcohol use on the outcome of treatment response. In summary, many critical questions remain regarding the interactions between alcohol and hepatitis C. Currently, the evidence from the literature shows that heavy alcohol intake worsens the outcome of HCV infection. The literature is inadequate to provide definitive recommendations regarding the effect of light to moderate alcohol use in patients with hepatitis C. (Hepatology 2002;36:S220-S225).
Commentary
Authors: Lester S. King
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myasthenic (vertical) nystagmus. Verification by edrophonium tonography
Authors: J. R. Keane
Journal: JAMA (1970)

An unusual delayed-onset myasthenic nystagmus appearing during sustained upward gaze suggested the presence of brain-stem disease in a 35-year-old construction worker who was being evaluated for his complaints of progressive instability of gait. The etiology of the nystagmus and the systemic symptoms was established objectively by an edrophonium chloride (Tensilon) tonogram test; this is a sensitive means of recording edrophonium-induced increase in extraocular muscle tone as indicated by a rise in the Schiotz tonogram.
A prospective evaluation of pulmonary, cardiac, and hepatic function (fn) in ‘tAnGo’: A randomized phase III trial of gemcitabine (G) in paclitaxel (T)-containing, epirubicin/cyclophosphamide (EC)-based, adjuvant chemotherapy (CT) for early stage breast cancer
Authors: C. J. Poole, H. C. Howard, L. Hiller, J. A. Dunn, A. M. Wardley, A. Bowman, R. E. Coleman, I. N. Fernando, D. M. Ritchie, H. M. Earl
Journal: Journal of Clinical Oncology (2004)

821 Background: tAnGo is an ongoing 3000-patient (pt) randomized trial evaluating for the first time the role of G in adjuvant CT for breast cancer. We present the results of a preliminary prospective safety study designed to assess the incidence of any treatment (trt)-related clinical or sub-clinical disturbances of pulmonary, cardiac, or hepatic fn in the first 135 pts randomised. Methods: Pulmonary (Hb-adjusted TLCO, FEV1, FVC, CXR), cardiac (LVEF, ECG), and hepatic (AST/ALT) fn tests were conducted in 135 pts (66 EC+T, 69 EC+GT) at baseline, mid-CT, post-CT/pre-RT, and 6 months post-CT. Results: Pulmonary fn tests: majority normal at all time points, with no differences between trts or changes over time in FEV1 (p>0.3 and 0.9 resp) or FVC (p=0.95 and 0.5 resp). TLCO dropped marginally during trt (p<0.001), slightly lower for EC+GT pts (p=0.03). 94% of all CXRs normal with no differences between trts (p>0.25) and no changes over time (p=0.14). Cardiac fn tests: 95% of all Echo/MUGA scans and 90% of all ECGs normal, with no differences between trts (p>0.35 and >0.25 resp) and no changes in Echo/MUGAs over time (p=0.4); only a slight time effect in ECGs (p=0.03). Hepatic fn tests: 92% of all AST levels and 82% of all ALT levels normal (majority of abnormal results graded 1/2): EC+T pts show a modest increase in transaminases at mid-CT but this resolves by post-CT (AST p=0.08 and ALT p=0.38 for change over time); transaminase increases in EC+GT pts persist post-CT but resolve by 6 months (AST p=0.004 and ALT p=0.001 resp for change over time). Acute skin toxicity during RT: 87% of reports graded this as Nil/Mild; only 1% as severe; no difference between trts (p>0.1), although severity increased over time (p<0.0001). There were no trt related deaths. Conclusions: These data suggest that clinically relevant trt effects on pulmonary or cardiac fn will be rare over the course of the entire study. Reported transaminase increases are both modest and reversible. Long term follow-up tests will be performed at 5 and 10 yrs. No significant financial relationships to disclose.
A Modeling Framework for Estimating Children's Residential Exposure and Dose to Chlorpyrifos Via Dermal Residue Contact and Nondietary Ingestion
Authors: Valerie G. Zartarian, Haluck Ozkaynak, Janet M. Burke, Maria J. Zufall, Marc L. Rigas, Edwin J. Furtaw
Journal: Environmental Health Perspectives (2000)

To help address the Food Quality Protection Act of 1996, a physically based probabilistic model has been developed to quantify and analyze dermal and nondietary ingestion exposure and dose to pesticides. The Residential Stochastic Human Exposure and Dose Simulation Model for Pesticides (Residential-SHEDS) simulates the exposures and doses of children contacting residues on surfaces in treated residences and on turf in treated residential yards. The simulations combine sequential time-location-activity information from children's diaries with microlevel videotaped activity data, probability distributions of measured surface residues and exposure factors, and pharmacokinetic rate constants. Model outputs include individual profiles and population statistics for daily dermal loading, mass in the blood compartment, ingested residue via nondietary objects, and mass of eliminated metabolite, as well as contributions from various routes, pathways, and media. To illustrate the capabilities of the model framework, we applied Residential-SHEDS to estimate children's residential exposure and dose to chlorpyrifos for 12 exposure scenarios: 2 age groups (0-4 and 5-9 years); 2 indoor pesticide application methods (broadcast and crack and crevice); and 3 postindoor application time periods (< 1, 1-7, and 8-30 days). Independent residential turf applications (liquid or granular) were included in each of these scenarios. Despite the current data limitations and model assumptions, the case study predicts exposure and dose estimates that compare well to measurements in the published literature, and provides insights to the relative importance of exposure scenarios and pathways.
Morita Psychotherapy
Authors: Marjorie C. Meehan
Journal: JAMA (1976)

In 1917, Morita first described his method of treating neurasthenia, a method compatible with Japanese cultural attitudes and designed to treat a type of neurosis especially common among his people. Over the years, his methods have been modified by various followers, influenced by some Western ideas and changing attitudes among the Japanese people. Reynolds, an anthropologist, spent several years in Japan observing and participating in Morita therapy as both patient and therapist. He now presents a clear, coherent report. Morita's method is primarily designed to treat a form of neurosis characterized by shyness, self-consciousness, inferiority feelings, difficulty in working, anxiety about body odors, and other concerns. Morita believed that this neurosis resulted from conflict between a healthy strong self-actualizing drive and a hypochondriacal temperament manifested by perfectionism and introspectiveness. Usually the neurosis was precipitated by some frustrating experience or minor illness that led the patient to center his attention on