tbuckley/cabot-search huggingface dataset:
A NEW THEORY OF "URÆMIA."
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gomers
Authors: Daniel J. Moller
Journal: JAMA (1980)

<h3>To the Editor.—</h3> I enjoyed the short article on "Gomers" (243:2333, 1980). I was disappointed, however, that no reference was made to the benchmark treatise on that subject—a novel named<i>The House of God</i>, by Samuel Shem, MD. In his book, Dr Shem poignantly addresses not only gomers, but also their effects on us as physicians. His account of what the practice of medicine does to physicians is accurate. I think that the insights provided by the book make it required reading for anyone engaged in our profession.
The Societe Medico-Psychologique of Paris and the Townley Case
Authors: C. L. Robertson
Journal: BMJ (1865)

<b>Background:</b> Several clinical and experimental lines of evidence suggest that leucotriene B4 (LTB4), an arachidonic acid derivative with potent proinflammatory properties, plays a key role in the pathophysiology of rheumatoid arthritis (RA). <b>Objective:</b> To evaluate the efficacy and safety of BIIL 284, an oral long-acting LTB4 receptor antagonist, as monotherapy for the treatment of patients with active RA. <b>Methods:</b> This was a multi-centre, randomised, double-blind, placebo-controlled trial of patients with active RA of 3 months’ duration. A total of 342 patients were randomised to receive 5 mg, 25 mg or 75 mg of BIIL 284 or placebo. The primary end point was the percentage of patients achieving an American College of Rheumatology (ACR) 20. <b>Results:</b> Although a higher percentage of ACR 20 responders was observed in the groups treated with 25 mg and 75 mg of BIIL 284 compared with those treated with placebo, no statistically significant differences were found between any of the three active treatment groups compared with the placebo group with regard to the primary or secondary end points. All trial treatments were safe and well tolerated. <b>Conclusions:</b> This clinical trial demonstrates that treatment of patients with active RA with a potent oral long-acting LTB4 receptor antagonist produced only modest improvements in disease activity. The results of this trial support the conclusion that LTB4 is not a major contributor to the inflammatory process in RA.
Book Review Sulfanilamide, Sulfapyridine and Allied Compounds in Infections . By Maurice A. Schnitker, M.D. Edited by Henry A. Christian, A.M., M.D., LL.D., Sc.D. (Hon.), Hon. F.R.C.P. (Can.). 8°, cloth, 72 pp., with 4 illustrations. New York: Oxford University Press, 1940. $1.50.
Journal: New England Journal of Medicine (1941)
DOMESTIC CORRESPONDENCE.
Authors: J. M. Mathews
Journal: JAMA (1892)

<h3>To the Editor of the Journal of the American Medical Association:</h3> I have just seen inThe Journalof January 2, in your report of the proceedings of the Mitchell District Medical Society, the following as purported to have been said by me, in reply to Dr. Wathen's discussion of Dr. Reed's paper. "The speaker said Dr. Wathen had made a statement that should not go unanswered, which was, that all young girls up to 20 of age, who suffered from irregular menstruation, should be examined,looking,he supposed Dr.Wathen meant,for cancer." At the meeting referred to I jocularly referred to some remarks made by Dr. Wathen, but for fear that the interpretation of what I said might be misconstrued,I write to correct the idea that Dr. Wathen meant to convey any such impression that every young girl up to 20 years of age, should be examined,that suffered from irregular menstruation.
Simultaneous intra-operative sampling from multiple anatomical sites reveals pro-inflammatory liver homing T cells in liver, adipose tissue and peripheral blood in patients with NASH
Authors: James Brindley, Falguni Tailor, Karthik Chandrasekharan, Kathryn Waller, Anja Versteeg-de Jong, Kalpana Devalia, Sanjay Agrawal, Francesca Rosini, John Loy, William Alazawi
Journal: Journal of Hepatology (2020)
Risk Stratification Model for Resected Squamous Cell Lung Cancer (R-Sqlc) Patients (Pts) According to Clinical and Pathological Factors
Authors: E. Bria, S. Pilotto, U. Peretti, M. Milella, F. Facciolo, S. Novello, A. Marchetti, L. Crinò, S. Kinspergher, A. Santo, M. Brunelli, I. Sperduti, M. Chilosi, A. Scarpa, G. Tortora
Journal: Annals of Oncology (2014)
Birth of a Medical School in Kenya
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults
Authors: Yaseen M. Arabi, Abdulaziz S. Aldawood, Samir H. Haddad, Hasan M. Al-Dorzi, Hani M. Tamim, Gwynne Jones, Sangeeta Mehta, Lauralyn McIntyre, Othman Solaiman, Maram H. Sakkijha, Musharaf Sadat, Lara Afesh
Journal: New England Journal of Medicine (2015)

The appropriate caloric goal for critically ill adults is unclear. We evaluated the effect of restriction of nonprotein calories (permissive underfeeding), as compared with standard enteral feeding, on 90-day mortality among critically ill adults, with maintenance of the full recommended amount of protein in both groups.At seven centers, we randomly assigned 894 critically ill adults with a medical, surgical, or trauma admission category to permissive underfeeding (40 to 60% of calculated caloric requirements) or standard enteral feeding (70 to 100%) for up to 14 days while maintaining a similar protein intake in the two groups. The primary outcome was 90-day mortality.Baseline characteristics were similar in the two groups; 96.8% of the patients were receiving mechanical ventilation. During the intervention period, the permissive-underfeeding group received fewer mean (±SD) calories than did the standard-feeding group (835±297 kcal per day vs. 1299±467 kcal per day, P<0.001; 46±14% vs. 71±22% of caloric requirements, P<0.001). Protein intake was similar in the two groups (57±24 g per day and 59±25 g per day, respectively; P=0.29). The 90-day mortality was similar: 121 of 445 patients (27.2%) in the permissive-underfeeding group and 127 of 440 patients (28.9%) in the standard-feeding group died (relative risk with permissive underfeeding, 0.94; 95% confidence interval [CI], 0.76 to 1.16; P=0.58). No serious adverse events were reported; there were no significant between-group differences with respect to feeding intolerance, diarrhea, infections acquired in the intensive care unit (ICU), or ICU or hospital length of stay.Enteral feeding to deliver a moderate amount of nonprotein calories to critically ill adults was not associated with lower mortality than that associated with planned delivery of a full amount of nonprotein calories. (Funded by the King Abdullah International Medical Research Center; PermiT Current Controlled Trials number, ISRCTN68144998.).
A 16 year study of injuries to professional kickboxers in the state of Victoria, Australia
Authors: T R Zazryn, C F Finch, P McCrory
Journal: British Journal of Sports Medicine (2003)

Objectives: To determine the rate and type of injuries occurring to registered professional kickboxers in Victoria, Australia over a 16 year period. Methods: Data describing all fight outcomes and injuries sustained during competition for the period August 1985 to August 2001 were obtained from the Victorian Professional Boxing and Combat Sports Board. Results: A total of 382 injuries were recorded from 3481 fight participations, at an injury rate of 109.7 injuries per 1000 fight participations. The most common body region injured was the head/neck/face (52.5%), followed by the lower extremities (39.8%). Specifically, injuries to the lower leg (23.3%), the face (19.4%), and intracranial injury (17.2%) were the most common. Over 64% of the injuries were superficial bruising or lacerations. Conclusion: The nature of kickboxing, whereby kicking the opponent is the prime movement and the head a prime target, is reflected in the distributions of body regions most commonly injured by participants. Further research into injury patterns in different styles of kickboxing and the mechanism of injury occurrence is required. Exposure adjusted prospective studies are needed to monitor injury rates over time.
LEGISLATION FOR FREAKS AND FRAUDS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTH-038 Genetic polymorphism of the CCK and CCK1 receptor genes does not affect gastric function or reported satiety
Authors: R B Jones, A Payton, W E Ollier, G J Dockray, D G Thompson
Journal: Gut (2010)

<h3>Introduction</h3> The importance of genetic polymorphism in determining physiological responses is becoming increasingly apparent. Genetic polymorphism if the CCK1 receptor has been implicated in obesity1 and delayed gastric emptying.2 It is not known if common polymorphisms of CCK and the CCK1 receptor affect function and phenotype. Objectives: To determine if common genetic polymorphisms of the CCK or CCK1 receptor influence the magnitude of change in gastric emptying or feelings of fullness and hunger in response to CCK1 receptor antagonism. <h3>Methods</h3> Saliva was obtained from 520 white Caucasoid individuals aged between 18 and 60 and analysed for single nucleotide polymorphisms (SNPs). Haplotype blocks were identified and 25 individuals (12 female, mean age 23, mean BMI 23.7) who were found to be homozygous for four different variants of these blocks (H1-4), underwent three liquid gastric emptying (GE) studies using the <sup>13</sup>C acetate breath test, both with and without the CCK1 receptor antagonist dexloxiglumide (600 mg). These individuals filled in visual analogue scales (VAS) for hunger and fullness at 5-minute intervals for the duration of the studies (45 minutes). Mean per cent increase in gastric emptying with dexloxiglumide was calculated and compared across the genotypes. <h3>Results</h3> No difference in the proportional increase in gastric emptying rate after dexloxiglumide was seen between the different haplotype groups: per cent increase in GE rate±SD: H1 (n=10) 35.8±20, H2 (n=5) 34.2±16, H3 (n=5) 34.3±28, H4 (n=5) 47.8±25. ANOVA p=0.66. No significant difference in changes in VAS scores for hunger or fullness was seen after dexloxiglumide between the different haplotype groups. <h3>Conclusion</h3> Common genetic polymorphisms of the CCK or CCK1 receptor gene do not appear to affect the magnitude of CCK response to a nutrient stimulus. No difference in changes in reported feelings of fullness and hunger after dexloxiglumide are seen with genetic polymorphism of these genes.
From the Centers for Disease Control. Seasonality in sudden infant death syndrome
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Cell Biology, New York
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is Nitrous Oxide a Dangerous Anesthetic for Vitamin B12-Deficient Subjects?-Reply
Authors: Robert F. Schilling
Journal: JAMA (1986)

<h3>In Reply.—</h3> I thank Drs Koblin and Biebuyck for detecting my error. Ethrane, not ethane, was used. For patient 2 the agents used on Aug 31, 1982, were 65% nitrous oxide, Ethrane, pentothal, and fentanyl. The agents used on Oct 28, 1982, included 60% nitrous oxide, thiopental, fentanyl, and lidocaine.
Evaluation of the Pediatric Trauma Score
Authors: C. R. Kaufmann
Journal: JAMA (1990)

A Pediatric Trauma Score (PTS) was recently developed and is rapidly gaining acceptance as a triage tool. This study examines the utility of the PTS as compared with the Revised Trauma Score, which is applicable to all ages. The charts of 376 children 0 to 14 years of age who were admitted to the trauma service of a level 1 trauma center were reviewed. Significant correlations were found for both the PTS and the Revised Trauma Score with survival, the Injury Severity Score, APACHE II score, vital signs, the Glasgow Coma Scale score, hematocrit, need for an operation, and number of days in an intensive care unit. The PTS was of no statistical advantage as compared with the Revised Trauma Score. Triage accuracy was 68.3% for the PTS and 78.8% for the Revised Trauma Score. The Revised Trauma Score is easy to use and universal in its applicability. The PTS involves learning a separate scoring system and is of no advantage. (<i>JAMA</i>. 1990;263:69-72)
Highlights
Journal: JAMA Surgery (2013)

Breast Cancer Treatment in the Veterans Health Administration (VHA) 999In 2007, the VHA prioritized expansion of screening mammography services.In this context, Kvasnovsky and coauthors performed a retrospective evaluation of breast cancer cases treated at the Baltimore Veterans Affairs (VA) Medical Center from 2000 to 2012, comparing process-of-care metrics before and after the expansion.Mammography and breast cancer volumes increased significantly (1200% and 61%, respectively).Most patients required non-VA referral for specialized services not available on-site.The time from diagnosis to definitive treatment also increased significantly (from 33 days to 51 days; P = .03),suggesting that the VHA might benefit from acquiring fully on-site breast cancer services.
Intensive Therapy for Small-Cell Lung Cancer Using Carboplatin Alternating With Cisplatin, Ifosfamide, Etoposide, Mid-Cycle Vincristine, and Radiotherapy
Authors: Joseph Prendiville, John Radford, Nick Thatcher, Will Steward, Malcolm Ranson, Paul Burt, Ron Stout
Journal: Journal of Clinical Oncology (1991)

An error was made at the final printing stage of the report entitled "Intensive Therapy for Small-Cell Lung Cancer Using Carboplatin Alternating With Cisplatin, Ifosfamide, Etoposide, Mid-Cycle Vincristine, and Radiotherapy" by Prendiville et al (J Clin Oncol 9:1446–1452). Under the Treatment Regimens section, the first sentence of the second paragraph should read "On day 5 of the first cycle of chemotherapy, prophylactic cranial irradiation was given by opposing lateral fields in one fraction of 8 Gy."
PENICILLIN HYPERSENSITIVITY IN ENTEROCOCCAL ENDOCARDITIS
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osler
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular Epidemiology in Environmental Health: The Potential of Tumor Suppressor Gene p53 as a Biomarker
Authors: Jan C. Semenza, Lisa H. Weasel
Journal: Environmental Health Perspectives (1997)

One of the challenges in environmental health is to attribute a certain health effect to a specific environmental exposure and to establish a cause-effect relationship.Molecular epidemiology offers a new approach to addressing these challenges.Mutations in the tumor suppressor gene p53 can shed light on past environmental exposure, and carcinogenic agents and doses can be distinguished on the basis of mutational spectra and frequency.Mutations in p53 have successfully been used to establish links between dietary aflatoxin exposure and liver cancer, exposure to ultraviolet light and skin cancer, smoking and cancers of the lung and bladder, and vinyl chloride exposure and liver cancer.In lung cancer, carcinogens from tobacco smoke have been shown to form adducts with DNA.The location of these adducts correlates with those positions in the p53 gene that are mutated in lung cancer, confirming a direct etiologic link between exposure and disease.Recent investigations have also explored the use of p53 as a susceptibility marker for cancer.Furthermore, studies in genetic toxicology have taken advantage of animals transgenic for p53 to screen for carcinogens in vivo.In this review, we summarize recent developments in p53 biomarker research and illustrate applications to environmental