tbuckley/cabot-search huggingface dataset:
Dietary fat intake in the aetiology of barrett's oesophagus and oesophageal adenocarcinoma: data from a prospective cohort study (EPIC-Norfolk) using 7-day food diary data
Authors: M. Yates, R. Luben, E. Cheong, L. Igali, R. Fitzgerald, K.-T. Khaw, A. Hart
Journal: Gut (2011)

<h3>Introduction</h3> Dietary fat may be involved in the aetiology of both Barrett9s oesophagus (BO) and oesophageal adenocarcinoma (OAC) through its direct and indirect effects on increasing oesophageal reflux and second the release of adipose derived hormones. The aim of this investigation was to conduct the first prospective cohort study of dietary fat in the aetiology of these diseases, using nutritional data derived from 7-day food diaries (7-DFD). <h3>Methods</h3> A total of 23 658 healthy men and women were recruited into EPIC-Norfolk (European Prospective Investigation In to Cancer and Nutrition) between the years 1993 and 1997. Participants completed 7-DFDs at recruitment which recorded detailed information on food types consumed, brands, quantities and frequency of intake and cooking methods. The diaries were coded by nutritionists using a computer programme containing information on 11 000 food items and 55 000 portion sizes. Participants were followed up to identify those who had a new diagnosis of either BO or OAC and the diagnoses confirmed by reviewing the medical records. Hazard ratios were estimated using Cox regression for quintiles of total fat, saturated fat and total polyunsaturated fat (PUFA) intakes, for BO and OAC respectively, adjusted for age, gender, smoking, body mass index and total energy intake. <h3>Results</h3> In the cohort, 80 participants had endoscopy showing a new diagnosis of BO (80% men, median age=69.4 years range 41.3–84.4 years) and a further 58 were diagnosed with OAC (84% men, median age=73 years, range 52–86 years). The risk of OAC was positively associated with a higher fat intake (highest vs lowest quintiles HR=3.77, 95% CI=0.83 to 17.03, p=0.085, trend HR=1.54, 95% CI=1.08 to 2.19) and saturated fat intake (trend HR=1.35, 95%, 95% CI=1.01 to 1.79), but not with PUFAs (trend HR=1.11, 95% CI=0.87 to 1.42). For BO, there were no associations with either: total fat, saturated fat or PUFAs. <h3>Conclusion</h3> The data, together with plausible biological mechanisms, support a role for total fat and saturated fatty acids in the aetiology of OAC. Their role in BO needs further clarification as this sub-group were participants diagnosed as a result of developing symptoms and undergoing gastroscopy. Future epidemiological work should measure dietary fat intake when investigating the aetiology of this aggressive cancer. This has implications for potential public health interventions lowering dietary fat to reduce the incidence of OAC.
Helvetica Paediatrica Acta, Basel
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunology
Authors: Roberto Kretschmer
Journal: JAMA (1982)

To write a textbook of immunology seems an almost hopeless endeavor nowadays. Such is the speed of progress in this field that, as the ink begins to dry, abundant and fascinating new knowledge emerges, and the books drift inexorably toward joyless outdatedness. Only a few manage to blend time-resistant concepts with new information in a balanced fashion. <i>Immunology</i>by J. F. Bach and collaborators was one such book when its first edition (1976—French, 1978— English) appeared, and it certainly remains so in this second edition (1979—French, 1982—English). Add to this its thoroughness, its gallic lucidity of exposition, and its successful counterpoint of basic and clinical material, and you have what is possibly the best textbook of immunology presently available. The translation (and modification) is excellent, yet, surprisingly, no fair credit is given to whoever was responsible for it (Mrs Bach and R. S. Swenson?). This new and enlarged (+25%) edition
Review of Glycol Ether and Glycol Ether Ester Solvents Used in the Coating Industry
Authors: R. L. Smith
Journal: Environmental Health Perspectives (1984)

Ethylene oxide-based glycol ether and glycol ether ester solvents have been used in the coatings industry for the past fifty years. Because of their excellent performance properties (evaporation rate, blush resistance, flow-out and leveling properties, solubility for coating resins, solvent activity, mild odor, good coupling ability, good solvent release) a complete line of ethylene oxide-based solvents of various molecular weights has been developed. These glycol ether and glycol ether ester solvents have better solvent activity for coating resin than ester or ketone solvents in their evaporation rate range. The gloss, flow and leveling, and general performance properties of many coating systems are dependent on the use of these products in the coating formula. Because of the concern about the toxicity of certain ethylene oxide-based solvents, other products are being evaluated as replacements in coating formulas.
Trends in Intake of Energy and Macronutrients—United States, 1971-2000
Journal: JAMA (2004)

During 1971-2000, the prevalence of obesity in the United States increased from 14.5% to 30.9%. Unhealthy diets and sedentary behaviors have been identified as the primary causes of deaths attributable to obesity. Evaluating trends in dietary intake is an important step in understanding the factors that contribute to the increase in obesity. To assess trends in intake of energy (i.e., kilocalories [kcals]), protein, carbohydrate, total fat, and saturated fat during 1971-2000, CDC analyzed data from four National Health and Nutrition Examination Surveys (NHANES): NHANES I (conducted during 1971-1974), NHANES II (1976-1980), NHANES III (1988-1994), and NHANES 1999-2000. This report summarizes the results of that analysis, which indicate that, during 1971--2000, mean energy intake in kcals increased, mean percentage of kcals from carbohydrate increased, and mean percentage of kcals from total fat and saturated fat decreased. An expert advisory committee appointed by the U.S. Department of Health and Human Services and the U.S. Department of Agriculture (USDA) is conducting a review of the Dietary Guidelines for Americans. Revised guidelines will be published in 2005.
Common Bacterial Infections of the Digestive Tract, and the Intoxication Arising from Them.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of diagnostic accuracy of magnetic resonance ideal-iq sequence and controlled attenuation parameter for detecting liver steatosis
Authors: Xiaoling Chi, Meijie Shi, Huanming Xiao, Yubao Xie, Pengtao Zhao, Junmin Jiang, Gaoshu Cai, Shuduo Wu, Yingxian Li, Chaozhen Zhang, Sheng Li, Yupin Liu, Yu Yang
Journal: Journal of Hepatology (2020)
The inscrutable Kawasaki disease
Authors: P. Gunby
Journal: JAMA (1980)

Although medical investigators continue to study mucocutaneous lymph node (Kawasaki) disease from virtually every viewpoint, the cause and pathogenesis of this acute, sometimes fatal, febrile illness remain elusive. The disorder, now considered a syndrome, usually affects children younger than 5 years, although some cases now are being reported among adults (see page 1604, this issue). The death rate variously is reported to be between 0.5% and 2.8% or higher, and cardiovascular complications are not infrequent. Since Tomisaku Kawasaki, MD, Tokyo Red Cross Medical Center, reported the first cases in 1967, more than 20,000 cases have been reported in Japan. The disorder began to be recognized in the United States in 1974, and more than 650 cases have been recorded in this country since then. In fact, a cluster of 57 cases (mean age of the patients, 2.9 years), the largest so far in the United States, just occurred in Massachusetts.
Pediatric Orthopaedics
Authors: Harriet S. Meyer
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errata
Authors: At Worthing, Jeremiah Cloves, M Dove, W Dyer, Neve Sison, John Southern, James Douglas, W Eaststaff, Nathaniel Montefiore, Michael Hare, Charles Gibson, Arthur Steele, Henry Thomas Berry, Edward Pye, Peter Brotherston, Arthur Taylor, Charles Robison, James Rowlands, Charles Royle, Alfred Symonds, William Field, Ainger Burke, John Sparham, James Green, Alfred Anderson, Henry Uwins, Francis Pearce, James Thomson Waller, George Shelton, John Ward, Edward Apothecaries', Hall Licentiates Admitted Thursday, ; Lattey, J Davies, ; Davies, ; Miller, Cardiganshire Thomas, G Addethorpe, Lincoln Williams, W Stiff, J Graham, P Pope, Town Malling, F Ingoldby
Journal: BMJ (1842)

The Governors of the Gateshead Dispensary met on Tuesday, in the town-hall (George Sowerby, Esq., mayor, in the chair), to elect a house-surgeon and apothecary in the place of Dr. Timniswood, resigned
Amebic Pericarditis
Authors: Howard B. Shookhoff
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In reviewing my copies ofThe Journalfor 1972,I find that I overlooked the article entitled "Amebic Pericarditis" by Heller and associates (220:988, 1972). The interesting aspects of the two reported cases have been alluded to by the authors. I should like to add two observations. First, microscopic examination of the pus obtained at operation might well have established the diagnosis, especially if the drainage from the wound two or three days postoperatively was included. It is true that it is often difficult to find amebas in the pus of an amebic liver abscess when it is first drained, since the viable amebas usually are in the wall. After the abscess has been drained, it is more likely that organisms will be seen in the subsequent material that tends to come from the abscess wall. Necessarily, the specimens should be examined fairly soon after the material is
Simple blood test criteria for non-cirrhosis plus age and post-treatment AFP rule-out the risk of hepatocellular carcinoma development after SVR
Authors: Masayuki Kurosaki, Namiki Izumi, Jun Itakura, Kaoru Tsuchiya, Hiroyuki Nakanishi, Nobuharu Tamaki, Shun Kaneko, Yutaka Yasui
Journal: Journal of Hepatology (2020)
Recurrence
Authors: Jay Liveson
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapy for Advanced Forms Of Breast Cancer Discussed
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Handbook of Anatomy Being a Complete Compend of Anatomy Including the Anatomy of the Viscera, a Section on Surgical Anatomy, Numerous Tables, and Adopting the Newer Nomenclature Designated the Basle Nomenclature Commonly Called B N A.
Journal: JAMA (1931)

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RAILWAY SANITATION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Latest Forecast
Authors: Steven A. Schroeder
Journal: JAMA (1994)

The confluence of two important trends—the dramatic growth of managed care and the impending oversupply of physician specialists—is examined by Weiner<sup>1</sup>in this issue ofThe JOURNAL. Enrollment in managed care plans has increased from 12.5 million persons in 1983 to 45 million in 1993.<sup>2,3</sup>This growth will almost certainly continue whether or not the Clinton Health Security Act—or some variant—is enacted, because both the business sector and most state governments believe managed care is less expensive than traditional feefor-service medicine. See also p 222. Though "managed care" is now a familiar term, it embraces a widely diverse set of organizational and financing arrangements, including such tightly run group practice health maintenance organizations (HMOs) as Kaiser Permanente, looser affiliations of physicians and hospitals that are linked by marketing and payment formulas, and traditional forms of practice that are "managed" by a corporate third party that attempts to restrain
Human Palaeopathology
Authors: Lester S. King
Journal: JAMA (1966)

In the expanding search for knowledge, paleopathology offers an unusual challenge. The study of present-day diseases entails difficulty enough, even with the clinical and experimental techniques now available. How much more difficult is the study of disease that attacked persons long dead, persons who, when alive, moved in environments vastly different from our own! Nevertheless, with all the difficulty, the pathologic examination of archeological remains is fascinating. The present volume, admirably edited, brings us a symposium which is truly cross-disciplinary. The participants and discussants— and the carefully prepared discussions are as valuable as the formal papers—cover a wide range of expertise. They include representatives of internal medicine, anthropology, anatomy, pathology, bacteriology, orthopedics, radiology, physiology, and history of medicine. Only through the cooperation of many separate disciplines can we achieve a picture of diseases-in-the-past. Jarcho, after a fine historical survey of paleopathology in the United States, indicates the possibilities
The Renormalization of Smoking? E-Cigarettes and the Tobacco “Endgame”
Authors: Richard Furman, Pin Lu, Menu Setty, R Perez, Ailin Guo, Joelle Racchumi, Guozhou Xu, Jiao Ma, Susanne Steggerda, Morton Coleman, Christina Leslie, Y Wang
Journal: New England Journal of Medicine (2014)

corrections kinase activity.Introduction of the recombinant nonmutant and C481S BTK constructs into HEK 293 cells showed that phosphorylation of C481S BTK at Y223 became significantly less sensitive to ibrutinib inhibition than the nonmutant BTK did (half-maximal inhibitory concentration, 1006 nM vs. 2.2 nM) (Fig. 1B).Taken together, our data indicate that the C481S mutation disrupts the covalent binding between BTK and ibrutinib.The impaired binding leads to a loss of inhibition of BTK enzymatic activity that ultimately results in ibrutinib resistance in the patient.Consistent with the findings reported in the Journal by Woyach et al., 6 our studies confirm that BTK is a relevant pharmacologic target of ibrutinib from a genetic perspective.
CHANGES IN THE MOTOR GANGLION-CELLS ASSOCIATED WITH PERIPHERAL NEURITIS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Antihelmintic Flubendazole Inhibits Microtubules through a Mechanism Distinct From Vinca Alkaloids and Displays Preclinical Activity in Leukemia and Myeloma.
Authors: Paul A. Spagnuolo, Jiayi Hu, Rose Hurren, Ashley Di Meo, Jonathan Boss, Iman Ashali, Marcela Gronda, Xiaoming Wang, Reza Behesti Zavareh, Sumaiya Sharmeen, Noah Fine, Craig D Simpson, Robert Rottapel, Aaron D. Schimmer
Journal: Blood (2009)
Management of childhood asthma in Britain
Authors: A. Reay
Journal: JAMA (1974)

THE nature of bronchial asthma is still not entirely clear. The basic anomaly seems to be the increased lability of the bronchial tree so that it reacts excessively to a variety of stimuli, including inhalation of allergens, exercise, infection, and emotional stress. There is good evidence that this anomaly is common to children bearing the diagnostic labels of "recurrent wheezy bronchitis" and bronchial asthma.<sup>1,2</sup>Some older children whose clinical history clearly points to one specific allergen and in whom skin tests are confirmatory may benefit from desensitization. This is not the case in those sensitive to a wide range of allergens. The place in therapy of the desensitization of children to the house dust mite is not yet clear. It seems reasonable to advise measures to reduce dust in the home of any asthmatic child and to advocate avoidance of exposure to domestic animals only when there is a