tbuckley/cabot-search huggingface dataset:
Military declassifies some Gulf War documents
Authors: P. Cotton
Journal: JAMA (1994)

THE MILITARY is declassifying documents from Operation Desert Storm, hoping to quash reports of chemical warfare and other speculation surrounding symptoms reported by Gulf War veterans (<i>JAMA</i>. 1994;271:1559-1561). The move follows assertions by Sen Donald Riegle, Jr (D, Mich), that there is "clear evidence" from interviews his staff conducted with more than 600 Persian Gulf War veterans that troops were exposed to harmful levels of chemical, and possibly biological, agents during the war, and that such exposure may explain many of the symptoms some veterans are suffering. These include fatigue, progressive neuropathies, respiratory and gastrointestinal problems, skin rashes, chest pains, joint pain, irritability, memory and concentration problems, nervousness, depression, weakness, and sensitivity to certain chemicals. Some spouses and children of veterans also report the symptoms, suggesting that the syndrome is transmissible, according to a report issued by the Senate Committee on Banking, Housing and Urban Affairs, which Riegle chairs. That
Outcome Of Hematopoietic Cell Transplantation (HCT) In Pediatric Patients With Hodgkin Lymphoma (HL): Single Institution Results From Saudi Arabia
Authors: Hassan A Sumaili, Asim F Belgaumi, Amani A Al-Kofide, Amal Al-Seraihy, Hassan El-Solh, Abdallah Al-Jefri, Ali Al-Ahmari, Amal Mohamed, Mohammed Anas, Mouhab Ayas
Journal: Blood (2013)
Last Call for AMA-RPS Interim Meeting
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency Medical and Surgical Aid.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heterotopic Ossification Effect on Dual-Photon Absorptiometry of the Hip
Authors: CHARLES A. STEWART, GUO-LONG HUNG, DOUGLAS E. GARLAND, CHARLES D. ROSEN, RODNEY ADKINS
Journal: Clinical Nuclear Medicine (1990)

STEWART, CHARLES A. M.D*; HUNG, GUO-LONG M.D*; GARLAND, DOUGLAS E. M.D.†; ROSEN, CHARLES D. M.D.†; ADKINS, RODNEY Ph.D.† Author Information
Lyme arthritis.
Authors: D H Rees, J S Axford
Journal: Annals of the Rheumatic Diseases (1994)

Leader Lyme arthritisLyme disease is a multisystem disorder caused by the spirochaete Borrelia burgdorferi and transmitted by the Ixodid tick.It was first described in 1977 following an outbreak of arthritis in Lyme, Old Lyme and East Haddam, Connecticut, USA.'It seems likely, from phenotypic analysis of the different spirochaete isolates2 and previous reports of the dermatological3 and neurological4 5 manifestations that the disease originated in Europe.It was not, however, until the outbreak of arthritis in Lyme and subsequent isolation of a new spirochaete6 that the exact cause was identified.Lyme disease is a cause of considerable morbidity in the Northern hemisphere and continues to be the focus of intense research.There are more than 2500 articles published on the condition to date and recently, the Second European Symposium on Lyme disease was held in this country.78
Expanding Medicare and employer plans to achieve universal health insurance
Authors: K. Davis
Journal: JAMA (1991)

This article presents a proposal for expanding Medicare and employer-based health insurance plans to achieve universal health insurance. Under this proposed health care financing system, employers would provide basic health insurance coverage to workers and dependents, or pay a payroll tax contribution toward the cost of their coverage under Medicare. States would have the option of buying all Medicaid beneficiaries and other poor individuals into Medicare by paying the Medicare premiums and cost sharing. Other uninsured individuals would be automatically covered by Medicare. Employer plans would incorporate Medicare's provider payment methods. This proposal would result in incremental federal governmental outlays on the order of $25 billion annually. These new federal budgetary costs would be met through a combination of premiums, employer payroll tax, income tax, and general tax revenues. The principal advantage of this plan is that it draws on the strengths of the current system while simplifying the benefit and provider payment structure and instituting innovations to promote efficiency. (<i>JAMA</i>. 1991;265:2525-2528)
Ulcerative Colitis
Authors: M. Luther
Journal: BMJ (1954)

<h3>Abstract</h3> The daily sleep/wakefulness cycle is regulated by coordinated interactions between sleep- and wakefulness-regulating neural circuitry. However, the detailed neural circuitry mediating sleep is far from understood. Here, we found that glutamic acid decarboxylase 67 (Gad67)-positive GABAergic neurons in the ventral tegmental area (VTA<sub>Gad67+</sub>) are a key regulator of non-rapid eye movement (NREM) sleep in mice. VTA<sub>Gad67+</sub> neurons project to multiple brain areas implicated in sleep/wakefulness regulation such as the lateral hypothalamus (LH) and dorsal raphe nucleus. Chemogenetic activation of VTA<sub>Gad67+</sub> neurons promoted NREM sleep with higher delta power whereas optogenetic inhibition of these neurons induced prompt arousal from NREM sleep under highly somnolescent conditions, but not during REM sleep. <i>In vivo</i> fiber photometry recordings revealed that VTA<sub>Gad67+</sub> neurons showed the highest population activity in NREM sleep and the lowest activity in REM sleep. Acute brain slice electrophysiology combined with optogenetics revealed that VTA<sub>Gad67+</sub> neurons directly innervate and inhibit wake-promoting orexin/hypocretin neurons in the LH by releasing GABA. Taken together, we reveal that VTA<sub>Gad67+</sub> neurons play a crucial role in the regulation of NREM sleep.
Perinatal Medicine
Authors: Carolyn S. Crawford
Journal: JAMA (1980)

These two volumes represent the efforts of 48 Hungarian physicians and scientists to present a comprehensive review of perinatal medicine and to include references from the world literature. Volume 1 (512 pages) presents normal and complicated pregnancy, prenatal care, genetics, embryology, teratology, and intrauterine and intrapartum diagnoses. The chapters on embryology and teratogenesis are comprehensive and exceptionally well written. Several chapters on genetics are scattered throughout this volume and would be better presented in sequence. Unbalanced emphasis exists, with an entire chapter devoted to the fetal development of enzymatic activity, while premature rupture of the membranes is dismissed in two paragraphs, postmaturity in five, and meconium aspiration and group B streptococcal infections are omitted entirely. Recommendations for the management of diabetic and Rhsensitized pregnancies are outdated and do not reflect current practices in perinatal centers in this country. Such recommendations as heparin and hypertonic glucose in intrauterine growth retardation, saline
Cigarette smoking increases the risk of albuminuria among subjects with type I diabetes
Authors: H. P. Chase
Journal: JAMA (1991)

The effect of cigarette smoking on diabetic renal and retinal complications was evaluated in 359 young subjects with insulin-dependent diabetes mellitus. The prevalence of increased albumin excretion rates was 2.8 times higher in smokers than nonsmokers. Mean glycohemoglobin levels and duration of diabetes were also significant factors in the development of diabetic nephropathy and retinopathy in a logistic regression model. Smoking remained a significant factor in the logistic regression model for albuminuria (but not retinopathy) when controlled for glycohemoglobin level, duration of diabetes, age, gender, and blood pressure. The progression of albuminuria and of retinopathy was also greater in smokers. Albuminuria improved significantly when subjects ceased smoking. It is concluded that cigarette smoking is an independent risk factor and is associated with the development and progression of early diabetic renal damage (albuminuria) and with the worsening of retinal disease in young subjects with diabetes. (<i>JAMA</i>. 1991;265:614-617)
Abdominal Surgery
Authors: Arthur W. Allen
Journal: New England Journal of Medicine (1948)

DURING the past year, the literature regarding surgery involving the abdominal region has been voluminous. Many studies pertaining to important variations in anatomic arrangements have been made. Lesions related to congenital defects and their effect on surgical conditions within the abdomen are significant. Detailed follow-up reports concerning life expectancy, especially in patients with malignant tumors, are helpful. Comparative results of the surgical treatment of common disorders in successive years, showing the marked improvement in morbidity and mortality, are impressive. Only articles giving new technics or approaches to usual conditions and those relating to rare disorders can be stressed in this . . .
LAW &amp;amp; MEDICINE
Authors: Angela Roddey Hold
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Aging Thyroid
Authors: Clark T. Sawin
Journal: JAMA (1989)

The overall prevalence of thyroid hormone use in an unselected population of older adults (n = 2575; average age, 68.6 years) was 6.9% (10.0% in women and 2.3% in men). Eighty-one percent of women taking it were doing so for appropriate indications, eg, hypothyroidism, while 12% were not, eg, for obesity or high serum cholesterol; more men (29%) were taking it inappropriately. Inappropriate use was associated with desiccated thyroid more than with thyroxine. After follow-up averaging 6.9 years, 58% of inappropriate users were still taking it. Underuse also occurred. Thirty-seven percent of those definitely hypothyroid had a clearly elevated serum thyrotropin level (&gt;10 mU/L) despite thyroid therapy. Thyroid therapy is common in the elderly; most is appropriate. When inappropriate use occurs, it is more common in men and more often associated with desiccated thyroid, still commonly used in this age group. In chronic users of thyroid hormone, it is important to review currently appropriate indications and to measure serum thyrotropin levels to assess the adequacy of treatment of primary hypothyroidism. (<i>JAMA</i>. 1989;261:2653-2655)
Predictive value of renin determinations in renal artery stenosis
Authors: M. H. Maxwell
Journal: JAMA (1977)

The prognostic value of renal vein and peripheral renin levels was analyzed in 66 patients with unilateral renal artery stenosis who underwent corrective surgery. Patient selection for operation was independent of renin results. Fifty-three percent of those with confirmed renovascular hypertension had renal vein renin ratios less than 2.0, ie, within the 95% confidence limit for the control group of 82 patients with essential hypertension. Thirty-four patients with clearly lateralizing renin data (ipsilateral:contralateral ≥1.5 and contralateral:peripheral ≤1.3) were benefited by operation, but 23 additional patients with nonlateralizing data also benefited. No proposed scheme for renin data analysis detected more than 75% of those with renovascular hypertension. Although lateralizing renin data are highly predictive of operative benefit, nonlateralizing data do not necessarily herald operative failure and should not be dogmatically used to exclude surgical intervention. (<i>JAMA</i>238:2617-2620, 1977)
THE EFFECT OF ULTRAVIOLET RAYS ON MILK AND EGGS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MAGNETIC HEALERS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Idiopathic Hyperlipemia
Authors: Winthrop C. Hopgood
Journal: New England Journal of Medicine (1948)

IDIOPATHIC hyperlipemia, an apparently benign disorder of neutral fat metabolism of unknown etiology, has been reported six times since Buerger and Grütz1 first described the syndrome in 1932. Thannhauser2 reviewed the reported cases to the time of the publication of his monograph in 1940. The essential features of this disorder consist of a grossly milky blood serum due to increase in neutral fat content, together with enlargement of the liver and spleen. Xanthomatous lesions of the skin may also be present. Unexplained abdominal colic has occurred in half the cases. A moderate reduction in blood fats has followed dietary treatment, . . .
From the NIH: Stable isotopes provide useful tools for a variety of metabolic studies
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME INTERESTING QUESTIONS IN MALARIA.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
苏金单抗治疗掌跖银屑病的研究
Authors: A.B. Gottlieb, A. Kubanov, M. Doorn, J. Sullivan, K.A. Papp, R. You, P. Regnault, J.A. Frueh
Journal: British Journal of Dermatology (2020)

掌跖银屑病是一种慢性(长期)、难以治疗的银屑病,累及手掌和足底。该病引起手掌和/或足底淡红色、鳞屑性斑块,伴或不伴身体其他部位的此类鳞屑。由于手掌和脚掌受累,患者在执行日常生活任务如行走、洗澡和进食时可能会出现严重问题。这会导致其生活质量严重紊乱,这类患者可能会社交退缩或患有抑郁症和信心不足。 一种名为苏金单抗的药物已被证明在治疗斑块状银屑病(背部、躯干、手部和腿部有鳞屑的银屑病)患者方面具有快速和持久的有效性;然而,尚未专门研究其对掌跖银屑病的作用。 随机对照试验是将患者随机分配到治疗组的一类临床试验,也有不接受任何研究中治疗的对照组。GESTURE 是规模最大、持续时间最长的随机对照研究,旨在评估苏金单抗在掌跖银屑病患者中的疗效和安全性。对即刻(16 周)和长期(2·5 年)结果进行了评估。 苏金单抗治疗使这些患者快速改善(最早从第 2 周开始),第 16 周的结果证明了苏金单抗治疗掌跖银屑病的疗效。对患者进行进一步治疗并随访至 2·5 年,以了解疗效是否持续或疾病是否再次出现(称为复发)。 2·5 年的结果证实苏金单抗治疗掌跖银屑病患者可产生持久的疗效。患者的手足功能得到改善,因此生活质量得到改善。未发现安全性问题。 本摘要涉及研究:苏金单抗对中重度掌跖银屑病患者的持续疗效:来自一项随机、双盲、安慰剂对照试验 GESTURE 的 2·5 年结果
NEW INVENTIONS.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contraception for the needy.
Journal: BMJ (1972)

severe than they could be.Policing is difficult-even impossible-with mass travel by car and small boats across the Channel.Only education and good sense can prevent irresponsible people from endangering us all.The immediate results of smuggling in a rabies-infected dog might be very similar to those described above, but the efficient measures so rapidly invoked in Vietnam would be put into effect more slowly and with greater difficulty in a civil than a military population.Veterinary surgeons need to be constantly aware of the possibility that a case of rabies may appear in their surgeries.Doctors, and particularly medical officers of health, would be well advised to keep themselves informed about the disease and make sure they have the rules for post-infection prophylaxis to hand.Enough vaccine and hyperimmune serum should always be available to treat a substantial num- ber of people at short notice.Because of the frequency of reactions after the administration of serum, the need for safe and effective hyperimmune globulin, preferably of human origin,7 must be emphasized.