tbuckley/cabot-search huggingface dataset:
Tempus fugit
Authors: Howard A. Rockman
Journal: Journal of Clinical Investigation (2013)

As I draft this editorial, it is almost a year into our stewardship as editors of the JCI. Previous Journal Editors have told me that the evaluation of manuscripts submitted across a broad range of topics and specialties was a highlight for their time as JCI Editor. I’ve found this to be no less true in my case, and I can speak confidently that the entire Editorial Board feels the same enjoyment. As I reflect upon the past year, I’m struck by feelings that range from immense privilege, to enormous responsibility, to, at times, near apoplectic bewilderment.
Cost-effectiveness
Authors: David M. Howard
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neomycin contact dermatitis superimposed on otitis externa
Authors: O. C. Jensen
Journal: JAMA (1966)

ALLERGIC sensitization to topically applied neomycin was first reported by Baer and Ludwig in 1952.<sup>1</sup>Their patient had otitis externa treated with neomycin, which was not typical of an acute contact dermatitis, but consisted of an exacerbation of the otitis externa. Since that time there have been several reports describing clinical patterns of neomycin sensitivity. However, the original theme of a gradually worsening dermatitis, or flares of an underlying dermatitis with treatment, characterizes most reports. Otitis externa was one of the most frequent conditions with which neomycin sensitivity was associated.<sup>2-4</sup>Familiar as these facts may be to the dermatologist, we feel that it has not been sufficiently emphasized in the literature reaching nondermatologists who are likely to treat the vast majority of patients with otitis externa. <h3>Materials and Methods</h3> Patch testing was performed on all patients generally following the method of Epstein.<sup>5</sup>One drop of 20% aqueous
Frog Skin Opioid Peptides: A Case for Environmental Mimicry
Authors: Lawrence H. Lazarus, Sharon D. Bryant, Martti Attila, Severo Salvadori
Journal: Environmental Health Perspectives (1994)

Naturally occurring environmental substances often mimic endogenous substances found in mammals and are capable of interacting with specific proteins, such as receptors, with a high degree of fidelity and selectivity. Narcotic alkaloids and amphibian skin secretions, introduced into human society through close association with plants and animals through folk medicine and religious divination practices, were incorporated into the armamentarium of the early pharmacopoeia. These skin secretions contain a myriad of potent bioactive substances, including alkaloids, biogenic amines, peptides, enzymes, mucus, and toxins (noxious compounds notwithstanding); each class exhibits a broad range of characteristic properties. One specific group of peptides, the opioids, containing the dermorphins (dermal morphinelike substances) and the deltorphins (delta-selective opioids), display remarkable analgesic properties and include an amino acid with the rare (in a mammalian context) D-enantiomer in lieu of the normal L-isomer. Synthesis of numerous stereospecific analogues and conformational analyses of these peptides provided essential insights into the tertiary composition and microenvironment of the receptor "pocket" and the optimal interactions between receptor and ligand that trigger a biological response; new advances in the synthesis and receptor-binding properties of the deltorphins are discussed in detail. These receptor-specific opioid peptides act as more than mimics of endogenous opioids: their high selectivity for either the mu or delta receptor makes them formidable environmentally derived agents in the search for new antagonists for treating opiate addiction and in the treatment of a wide variety of human disorders.
The Sick Sinus
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Justification
Authors: Bhuvana Chandra
Journal: Annals of Internal Medicine (2021)

Ad LibitumJanuary 2021JustificationBhuvana Chandra, MDBhuvana Chandra, MDPorter Ranch, California (B.C.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-3000 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail They come in from the numbing cold,lines of little black ants seeking warmthin my home, heading by instinct to the spacebeneath the stove, the cupboard where crumbsare easily come by, the microwave oven. (I'vegrown slack with my housekeeping.)My hand delves under the sink for the spray can.They trudge on—unknowing that death is onepress away—and mill on the countertop, coils ofdark silence on sugar-spilt tile. My finger stays. Whatis their crime? Winter manifests in varied forms …so in its quest, does sustenance.selves in if-only dreams; stretch our rations of hope ... Author, Article, and Disclosure InformationAffiliations: Porter Ranch, California (B.C.)Current Author Address: Bhuvana Chandra, MD; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics January 2021Volume 174, Issue 1Page: 123KeywordsAntsCrimeInstinctMemory ePublished: 19 January 2021 Issue Published: January 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Insulin Modulates Food-Related Activity in the Central Nervous System
Authors: Martina Guthoff, Yuko Grichisch, Carlos Canova, Otto Tschritter, Ralf Veit, Manfred Hallschmid, Hans-Ulrich Häring, Hubert Preissl, Anita M. Hennige, Andreas Fritsche
Journal: Endocrine Reviews (2010)

Previous data suggest a key role of central nervous insulin action in regulating energy homeostasis. We therefore investigated whether insulin modulates brain responses to food and nonfood pictures in a functional magnetic resonance imaging study. Nine healthy, normal-weight subjects underwent two functional magnetic resonance imaging measurements to compare the effects of insulin and placebo administration during a visual recognition task with food and nonfood pictures. Insulin was administered intranasally to raise insulin concentrations in the cerebrospinal fluid without altering systemic effects in the periphery. Metabolic parameters were continuously determined during the experiments. We measured the changes in brain activity after intranasal insulin administration. Food pictures were detected faster when compared to nonfood pictures in all conditions without any effect of placebo or insulin. After insulin application, fMRI measurements showed a significantly reduced activity in the presence of food pictures compared to placebo in the right and left fusiform gyrus, the right hippocampus, the right temporal superior cortex, and the right frontal middle cortex. The brain activation induced by nonfood pictures remained unaffected by insulin. We demonstrate that intranasal insulin led to a reduction of activity in brain areas related to object processing and memory and may have an effect on brain activation with regard to the processing of food pictures. This effect might be part of a mechanism that terminates food intake in the postprandial state.
Occupational Medicine
Authors: Harriet L. Hardy
Journal: New England Journal of Medicine (1952)

THIS report deals with the effects of chemical, bacteriologic and physical agents of known or possible hazard to the worker. The title "occupational medicine" was chosen as a description broad enough to include the laboratory worker, the farmer and the housewife. This is in contrast to the title "industrial medicine," which usually refers to groups of individuals engaged in operations of manufacturing such as ore smelting, storage-battery manufacture and sandblasting in a foundry. By this definition, consideration of the vast field of occupational health, which includes rehabilitation, preplacement examination, occupational psychiatry, the problems of the cardiac patient and the older . . .
Primary care
Authors: John J Ferguson
Journal: Journal of the Royal Society of Medicine (1998)

Dr John Ferguson is the current President of the Section of General Practice of the Royal Society of Medicine. He was in academic general practice in Edinburgh for 20 years and was involved in the continuum of medical education as a Senior Lecturer in the Department of General Practice and an Associate Regional Adviser in General Practice to the Edinburgh Postgraduate Board for Medicine. He is the past Chairman of the Examination Board of the Royal College of General Practitioners in London. In September 1992, he was appointed to the new post of Medical Director to the Prescription Pricing Authority in Newcastle upon Tyne, which is an NHS Special Health Authority, whose responsibility is to process over 518 million prescriptions per annum in England, and to arrange the payment in excess of £4.94 billion.
Covering wounds with cultured keratinocytes
Authors: D T Woodley
Journal: JAMA (1989)

One of the marvels of mammalian integument is the ability for wounds to heal. Unfortunately, the time from the onset of the wound until the time of healing may be prolonged and fraught with complications, morbidity, and even death. Disruption of the cutaneous barrier allows the possibility of water and electrolyte aberrations, infection, metabolic disturbances, and immune suppression in addition to short- and long-term pain. In recent years, a number of investigators have sought to develop a therapeutic approach to improving wound closure by using keratinocyte sheets generated from tissue culture. Keratinocytes in culture have the unique ability to proliferate rapidly and to stratify into an epidermal sheet that can be released from the Petri dishes, handled manually, and placed on wound beds. A functional tissue can thereby be generated from a limited number of cells in culture. Culture-derived tissue is useful for covering wounds because a small 5- to
CSIG-04. PAN-RTK INHIBITION OF sLRIG1 MEDIATES AXL DOWNREGULATION IN GLIOBLASTOMA
Authors: Virginie Neirinckx, Ann-Christin Hau, Anne Schuster, Sabrina Fritah, Andy Chevigné, Mirko H Schmidt, Simone Niclou
Journal: Neuro-Oncology (2019)

Abstract INTRODUCTION Aberrant regulation of receptor tyrosine kinase (RTK) activity is characteristic of Glioblastoma (GBM). However, RTK-based targeted therapies have been largely unsuccessful in GBM patients, partially due to the complexity and redundance of RTK signaling. LRIG1 (Leucine-rich Repeats and ImmunoGlobulin-like domains 1) is an important endogenous inhibitor of epidermal growth factor receptor (EGFR) during health and disease, however its mechanism of action is poorly understood. We previously showed that the soluble form of LRIG1 potently inhibits GBM growth in vivo, irrespective of EGFR expression level and status, suggesting the involvement of other RTKs. Here, we aimed to shed light on the molecular mechanisms underlying its anti-cancer activity. MATERIAL AND METHODS We generated a recombinant human soluble LRIG1 protein (rh-sLRIG1) by expressing LRIG1 ectodomain in insect cells via baculovirus infection and subsequent His-tag purification. rh-sLRIG1 was used to treat patient-derived GBM stem-like cells, classical GBM cell lines and patient-derived 3D tumor organoids. Using different cell-based assays, cell proliferation, invasion, cell morphology, as well as protein expression and protein-protein interactions were investigated. RESULTS We find that recombinant sLRIG1 efficiently reduced proliferation, invasion and viability of GBM cells and patient-derived organoids, and modulated cytoskeleton proteins and cell shape. In line with previous data, the effect of recombinant sLRIG1 was independent of EGFR expression. Interestingly sLRIG1 impacted multiple RTKs including AXL, by direct protein downregulation, while EGFR expression was not affected. At the molecular level, we find that sLRIG1 interfereed with AXL dimerization, while no protein interaction with EGFR was detected. CONCLUSION We identify AXL as a novel LRIG1 target and provide evidence that sLRIG1-mediated RTK downregulation requires direct protein-protein interaction. These data pave the way for a potential therapeutic application of recombinant sLRIG1 in the inhibition of growth factor signaling in GBM.
Aluminum "pop tops". A hazard to child health
Authors: J. D. Burrington
Journal: JAMA (1976)

In a 3 1/2-year period, seven children have been treated for complications of ingestion or aspiration of pull tabs from aluminum beverage cans. One child died from a fistula between the esophagus and a branch of the aortic arch, and two children suffered esophageal perforation with local abscess formation. Since aluminum absorbs x-rays poorly, the pull tabs cannot be seen in frontal projection if they overlie vertebral bodies. Any toddler with unexplained alteration of feeding habits or persistent respiratory symptoms requires evaluation for an aspirated or ingested foreign body. (<i>JAMA</i>235:2614-2617, 1976)
MARSHALL HALL (1790-1857)
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intensive Care
Authors: Eric S. Lichtenstein
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 August 1973Intensive CareEric S. Lichtenstein, m.d.Eric S. Lichtenstein, m.d.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-2-280 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his article, "Medical Intensive Care in the Teaching Hospital: Costs Versus Benefits" (April 1973 issue, pp. 581-585), Dr. Griner neatly describes the dilemma of intensive care. It is characterized by the economic necessity for cost-effectiveness judgments counter to all altruistic and professional impulses. There can be little argument as to the obvious necessities for intensive or critical care facilities in high-quality, comprehensive teaching and research programs. In evaluating the expense-benefit ratio of patient care, Dr. Griner unfortunately considers only the necessity of establishing, by statistical and value judgments, an approach-avoidance position between cost and adequacy of...REFERENCE1. AfifiSacksLiu ASV: Accumulative prognostic index for patients with barbiturate, glutethimide and meproba-mate intoxication. N Engl J Med 285:1497-1502, 1971 CrossrefMedlineGoogle Scholar1. MatherPearsonRead HNK: Acute myocardial infarction: home and hospital treatment. Br Med J 3:334-338, 1971 CrossrefMedlineGoogle Scholar2. BloomPeterson BO: End results, cost and productivity of coronary care units. N Engl J Med 288:72-78, 1973 CrossrefMedlineGoogle Scholar3. Griner P: Treatment of acute pulmonary edema: conventional or intensive care? Ann Intern Med 77:501-506, 1972 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 5937 Anniston Road Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1973Volume 79, Issue 2Page: 280-281KeywordsCritical carePatients Issue Published: 1 August 1973 PDF DownloadLoading ...
Author! Author!
Authors: Pythia T Nieuwkerk
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bilharziasis
Authors: K. J. Ho
Journal: JAMA (1967)

Bilharziasis or schistosomiasis is well-known as one of the common parasitic infestations in man. It has been estimated that 180 to 200 million people are infested in the whole world. Although the adult worm was first discovered by Bilharz in 1851, it took more than half a century to discover the life cycle of this fluke. Our knowledge about bilharziasis is still quite incomplete 116 years after Bilharz' first case. Therefore, a symposium on bilharziasis, organized by the editor at the invitation of the International Academy of Pathology for the Fifth International Congress, was held at the Royal College of Surgeons, London, in June 1964. This book is the product of this international symposium. The life cycle and epidemiology are reviewed briefly but clearly. The whole book emphasizes mostly the clinicopathological aspects of bilharziasis, such as urogenital, hepatosplenic, cardiopulmonary, and intestinal bilharziasis. Many interesting gross, histological, and x-ray pictures are
Incorrect Academic Degree
Authors: Charles Yoon, Mandeep Saund, Anita Courcoulas, Susan Yanovski, Mary Horlick
Journal: JAMA Surgery (2015)

Christina E. Bailey, MD, MSCI; Chung-Yuan Hu, MPH, PhD; Y. Nancy You, MD, MHSc; Brian K. Bednarski, MD; Miguel A. Rodriguez-Bigas, MD; John M. Skibber, MD; Scott B. Cantor, PhD; George J. Chang, MD, MS
TRAUMATIC ARTERIO-VENOUS ANEURYSMS OF THE SUBCLAVIAN VESSELS, WITH AN ANALYTICAL STUDY OF FIFTEEN REPORTED CASES, INCLUDING ONE OPERATED UPON.
Authors: RUDOLPH MATAS
Journal: JAMA (1902)

<h3>PRACTICAL CONCLUSIONS.</h3> As a result of the study of the arterio-venous aneurysms of the subclavian vessels which we have summarized in this contribution, we find that this class of injuries can be separated clinically and surgically into three distinct and well-defined groups: The immediately fatal cases in which death follows so quickly after the injury from the effect of the primary hemorrhage and shock that no effective surgical assistance can be rendered. These probably constitute the largest proportion of cases, especially in military practice, though an exact estimate can not be obtained. It is also probable that the vast majority of injuries involving the first and second divisions are fatal primarily, and are to be included in this group, except when the injuries are caused by small projectiles or sharp-pointed weapons. In this second group, primary hemorrhage may be very great, but spontaneous or temporary hemostasis occurs in the syncopal
ADDRESSES.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal