tbuckley/cabot-search huggingface dataset:
Reactions of Hemoglobin with Phenylhydrazine: A Review of Selected Aspects
Authors: Martin D. Shetlar, H. Allen O. Hill
Journal: Environmental Health Perspectives (1985)

It is well known that phenylhydrazine induces hemolytic anemia. This is thought to result from the reaction of phenylhydrazine with hemoglobin. The accompanying oxidation of phenylhydrazine leads to the formation of a number of products, including benzene, nitrogen, hydrogen peroxide, superoxide anion and the phenyl radical. The products formed depend critically on the conditions of the experiment, especially the amount of oxygen present. It is now known that oxyhemoglobin and myoglobin react with phenylhydrazine to yield a derivative of hemoglobin containing N-phenylprotoporphyrin in which the heme group is modified. The recent identification of sigma-phenyliron(III) porphyrins in phenylhydrazine-modified metmyoglobin has aided elucidation of the mechanism of hemoglobin modification. Mechanistic schemes are proposed to account for product formation.
Tumor of undescended testicle in an infant
Authors: J. L. Hansen
Journal: JAMA (1967)

A TERATOMA in the undescended testis of an infant is of such rarity that a search of the American literature published during the past ten years fails to show a reported case. I have no knowledge of any other reports. The following case report is rendered for that reason and with the hope that it may be of interest to those dealing with patients of similar age and sex, for teratoma is another lesion to be considered in the differential diagnosis of an intra-abdominal mass in an infant. Teratomas are neoplasms arising from totipotential cells that produce many types of tissue. They are most frequently found in the gonads but occur at times in the neck and mediastinum. They may become malignant. One can postulate that the presence of a tumor in an undescended testis indicates that its size may have prevented descent of the embryonic organ. This migration takes
Cardiac Deaths After a Mass Smallpox Vaccination Campaign— New York City, 1947
Journal: JAMA (2003)

During the first wave of the 2003 smallpox vaccination campaign, two ischemic cardiac deaths occurred in civilian vaccinees aged 55 and 57 years, and one occurred in a military vaccinee aged 55 years, 4-17 days after vaccination with the New York City Board of Health (NYCBOH) vaccinia strain. Whether these and 13 other recognized military and civilian nonfatal ischemic events among vaccinees were associated with smallpox vaccination is unclear. The same NYCBOH strain was used in 1947 to vaccinate approximately six million New York City (NYC) residents (80% of the population) during a 4-week period (April 4-May 2) after a smallpox outbreak. To determine whether smallpox vaccination increased the risk for cardiac death in 1947, the NYC Department of Health and Mental Hygiene (DOHMH) analyzed data from NYC death certificates during that period. This report summarizes the results of that analysis, which found no increases in cardiac, atherosclerotic, or all-cause deaths. The findings are consistent with a growing body of evidence suggesting that ischemic cardiac deaths observed after the 2003 campaign might have been unrelated to vaccine.
The Model T Ford Car, Truck and Tractor Conversion Sets; ALSO FORDSON FARM Tractor AND F. A. LIGHTING AND STARTING System Construction, Operation and Repair. The Most Complete, Practical Treatise Explaining the Operating Principles of all Parts of the Ford Automobile, with Instructions for Driving, Maintenance and Repairing; also Complete Instructions on Fordson Tractor.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiation Therapy
Authors: Margaret A. Holbrook
Journal: JAMA (1974)

RADIATION therapy has played little part in the therapeutic managerment of patients with gastric adenocarcinoma. In a retrospective study, we found no difference in survival between a group of 24 patients with localized but unresectable gastric carcinoma treated with radiation therapy and 43 patients with similar disease who received no specific treatment.<sup>20</sup> However, there are reports that chemotherapy with fluorouracil given in conjunction with radiation therapy has produced encouraging results.<sup>21,22</sup> We performed a randomized double-blind study of patients who had locally unresectable gastric adenocarcinoma and in whom all known disease could be encompassed by conventional radiation therapy fields.<sup>21</sup>All patients received radiation therapy at the rate of 900 rads to 1,200 rads per week to a total dose of 3,500 rads to 4,000 rads. By random selection, half of the patients received fluorouracil at a daily dosage of 15 mg/kg of body weight until a total dose
April
Authors: M. Therese Southgate
Journal: JAMA (1977)

April, they say, is the cruellest month. It is the time of wild barometric swings and violent meteorologic wars. Ulcers bleed and tornadoes hopscotch across the midwest prairies. In England, April is Chaucer's tale and Browning's sickness. Here, April is, as all Americans know, the time to pay their taxes. It is the time to sign the lease for May, or pack up and move. It is the time to be wherever, at this point in time, one is not. April is the only month with an entire day set aside especially for fools. April is brilliant and loud and unpredictable. It is pregnant with showers and snow. In April one goes to work on a spring morning and comes home through the heaviest blizzard of all the winter. April is the new winter coat gone suddenly shabby. It is the saucy crocus in the compost pile who doesn't believe
P1.04-80 Immunotherapy-Related Thrombosis: Considerations and Associated Factors in Non-Small Cell Lung Cancer (NSCLC) Patients
Authors: A.F. Cardona, O.G. Arrieta, A. Ruiz-Patiño, Z.L. Zatarain Barrón, L.L. Rojas, L. Corrales, C. Martin, F. Barrón, C. Sotelo, J. Rodriguez, L. Ricaurte, J. Ávila, M. Bravo, D. Mayorga, P. Archila, H. Freitas, V. Cordeiro De Lima, L. Mas, J. Otero, H. Carranza, C. Vargas, R. Rosell
Journal: Journal of Thoracic Oncology (2019)
159. Novel Oncolytic HSV Armed with Platelet Factor 4, an Antiangiogenic Agent, Shows Enhanced Efficacy
Authors: Ta-Chiang Liu, Tingguo Zhang, Hiroshi Fukuhara, Toshi Kuroda, Tomoki Todo, Robert L. Martuza, Samuel D. Rabkin, Andreas Kurtz
Journal: Molecular Therapy (2006)

Oncolytic herpes simplex viruses (HSV) have emerged as a promising platform for cancer therapy. However, efficacy as single agents has thus far been unsatisfactory. Tumor vasculature is critical in supporting tumor growth, but successful antiangiogenic approaches often require maintaining constant levels of antiangiogenic products. We hypothesized that oncolytic HSV has the potential to destroy tumor vasculature, and that this effect can be enhanced by combination with antiangiogenic gene transfer. We examined the strategy of arming oncolytic HSV with an antiangiogenic transgene, platelet factor 4 (PF4). The PF4 transgene was inserted into oncolytic HSV G47Δ utilizing a bacterial artificial chromosome (BAC) construction system. Whereas bG47Δ-empty showed robust cell killing and migration inhibition of proliferating endothelial cells (HUVEC and Py-4-1), the effect was further enhanced by PF4 expression. Importantly, enhanced potency did not impede viral replication. In vivo, bG47Δ-PF4 was more efficacious than it's non-expressing parent bG47Δ-empty at inhibiting tumor growth and angiogenesis in both human U87 glioma and mouse 37-3-18-4 malignant peripheral nerve sheath tumor (MPNST) models. Enhancing the antiangiogenic properties of oncolytic HSV through the expression of antiangiogenic factors such as PF4 is a powerful new strategy that targets both the tumor cells and tumor vasculature.
The pathogenesis of iron deficiency anemia following partial gastrectomy. A study of iron balance
Authors: C. Kimber
Journal: JAMA (1967)

Eight patients who had iron deficiency anemia after partial gastrectomy were tested to determine the role of blood loss and impaired absorption of iron in the individual case. Significant intermittent blood loss was documented in seven patients, while decreased iron absorption was found in only five. In four patients, both these factors were additive in causing iron deficiency. In the single patient with decreased absorption of the test dose of iron without evidence of bleeding, the anemia responded rapidly to therapeutic doses of orally administered iron. These data stress the relative importance of blood loss as a causal factor in iron deficiency after gastric surgery.
Intracellular cytokine repertoire in different T cell subsets from patients with sarcoidosis
Authors: M Möllers, S P Aries, D Drömann, B Mascher, J Braun, K Dalhoff
Journal: Thorax (2001)

BACKGROUND Pulmonary sarcoidosis is characterised by a mononuclear alveolitis with a predominance of CD4+ T cells and macrophages. We determined the intracellular expression of interferon (IFN)γ, interleukin (IL)-2, tumour necrosis factor (TNF)α, IL-4, IL-5 and IL-10 in CD4+ and CD8+, naive and memory lymphocytes from blood and bronchoalveolar lavage (BAL) fluid using three colour flow cytometry. METHODS Eighteen untreated patients with pulmonary sarcoidosis were evaluated and stratified according to whether they had acute or chronic disease. RESULTS Significantly more T cells expressed Th1 than Th2 type cytokines in both BAL fluid and peripheral blood samples, regardless of clinical presentation. Significantly greater proportions of T cells secreted Th1 type cytokines in BAL fluid than in peripheral blood. Th1 type cytokines were more frequently expressed by peripheral and alveolar T cells in acute disease than in chronic disease. There were no significant differences between CD4+ and CD8+ T cells. Concerning naive and memory lymphocytes, significantly higher CD45RO:CD45RA ratios were found in BAL fluid than in blood, and increased expression of Th2 type cytokines was found in peripheral compared with alveolar memory T cells. CONCLUSIONS Our data support the immunopathogenetic concept of Th1/Th2 imbalance and compartmentalisation in pulmonary sarcoidosis and suggest that the cytokine patterns change during the course of disease. Expression of Th2 type cytokines in memory lymphocytes is decreased in the alveolar compartment compared with peripheral blood.
The Achievement of the Army Medical Department in the World War
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
State medical boards discipline more, want role in health system reform
Authors: C. Marwick
Journal: JAMA (1994)

MORE PROBLEM physicians were disciplined last year by state medical licensing boards than in the previous 3 years. In 1993, a total of 3711 cases were recorded; there were 3370 in 1992. These figures on disciplinary actions taken by medical boards were released last month by the Federation of State Medical Boards. Hormoz Rassekh, MD, the federation's president and a psychiatrist in Council Bluffs, Iowa, notes that a total of 3081 prejudicial actions were taken against problem physicians. Actions involved punitive measures ranging from loss of license to limitation or restriction of license to probation to formal reprimand. The numbers represent nearly a 15% increase over the last 4 years, while the 1993 prejudicial actions taken by medical boards represent an increase of 3.6% over those in 1992. "This indicates the readiness of state medical boards to deal with the issues confronting medicine and delivery of medical care," said Rassekh,
<i>JAMA Surgery</i>Peer Reviewers in 2014
Authors: Christopher Abularrage, Naji Abumrad, Ali Aburahma, Riaz Agha, Waddah Al-Refaie, Alex Almoudaris, Daniel Anaya, B Atkins, Glenn Ault, William Gerald, Austen Samir, S Awad, B Faisal, G Bakaeen, Christopher Baker, Todd Baker, Charles Balch, Adrian Barbul, Marc Basson, John Beatty, Thomas Beaver, David Bentrem, David Berger, David Berger, Karl Bilimoria, James Black, Robin Blackstone, Jeffrey Blatnik, Richard Bold, Laura Boomer, Carl Bredenberg, L Britt, Benjamin Sands, Brooke David, C Brooks, Colleen Brophy, Carlos Brown, James Burdick, Ruth Bush, Joseph Carey, Sally Carty, Charles Cha, Elliot Chaikof, William Chapman, Cheadle Chen, Danny Chu, Brian Cmolik, Lorenzo Cobianchi, Amalia Cochran, Thomas Cogbill, Steven Colquhoun, Kevin Conlon, John Conte, Charles Cook, Matthew Cooper, Lorraine Cornwell, Bard Cosman, Michael Crittenden, Joseph Cullen, Steven Cunningham, Ronald Dalman, Alan Dardik, Lillian Dawes, Marc De Moya, Christian De Virgilio, Vincent Degennaro, E Patchen Dellinger, Daniel Dempsey, Ralph Depalma, Clifford Deveney, Karen Deveney, Justin Dimick, Sean Dineen, Quan-Yang Duh, E Barish, H Edil, Dan Eisenberg, Scott Ellner, Mark Eskandari, Laura Esserman, Richard Essner, David Euhus, Diana Farmer, Gladys Fernandez, Aaron Fink, P Marco, Fisichella Lee, Alan Fleisher, James Fleshman, Timothy Flynn, Glen Allen, Franklin Luke, Michael Funk, Vivian Gahtan, Susan Gearhart, David Geller, Amir Ghaferi, Rowan Gillies, Jason Gold, Matthew Goldblatt, Seth Goldstein, Philip Goodney, John Gore, Jon Gould, Caprice Greenberg, Jacob Greenberg, David Greenhalgh, Kurinchi Gurusamy, Daniel Hall, Hobart Harris, Linda Harris, Mary Hawn, Andrea Hayes-Jordan James, C Hebert, Peter Henke, Shawn Hervey-Jumper, Jonathan Hiatt, O Hines, Alice Ho, John Holcomb, Karen Horvath, Matthew Misty, Dawn Humphries, Eric Hungness, Karl Kenji, Inaba Hendrik, Isbarn Kamal, M Itani, Danny Jacobs, Robert Jensen, Hoonbae Jeon, Edwin Jesudason, Jason Michael, Johanning Haytham, M Kaafarani, Scott Kahan, Delawir Kahn, Lillian Kao, Brian Kaplan, Daniel Kassavin, Christina Kaufman, Henrik Kehlet, Rachel Kelz, M Margaret, Kemeny Peter, Thomas Kennealey, Anthony Kim, Jonathan Koea, Panos Kougias, Nicole Kounalakis, Geoffrey Krampitz, Robert Krouse, Mimi Leong, John Leppert, Lori Lerner, Antoon Lerut, Steven Libutti Brenessa, Michelle Lindeman, David Linehan, Dimitrios Linos, Pamela Lipsett, Kenneth Lipshy, Edward Livingston, Jayme Locke, William Long, Walter Longo, John Lucke, Ying Lum
Journal: JAMA Surgery (2015)
RICKETTSIAE AND DISEASE
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in the Figure 1 Caption, Table 1, and Supplement
Authors: Sabine Jenner, Sabine Oertelt-Prigione
Journal: JAMA Internal Medicine (2019)

Ji-Yan Chen, MD, PhD; Peng-Cheng He, MD, PhD; Yuan-Hui Liu, MD, PhD; Xue-Biao Wei, MD; Lei Jiang, MD, PhD; Wei Guo, MD, PhD; Chong-Yang Duan, MD; Yan-Song Guo, MD, PhD; Xiao-Ping Yu, MD, PhD; Jun Li, MD; Wen-Sheng Li, MD; Ying-Ling Zhou, MD, PhD; Chun-Ying Lin, MD, PhD; Jian-Fang Luo, MD, PhD; Dan-Qing Yu, MD, PhD; Zhu-Jun Chen, MD, PhD; Wei Chen, MD; Yi-Yue Chen, MD; Zhi-Qiang Guo, MD; Qing-Shan Geng, MD, PhD; Ning Tan, MD, PhD
BBS volume 1 issue 4 Front matter
Authors: Irving Kupfermann, Klaudiusz Weiss, G Hoyle, J Andreae, P Balaban, M Bennett, T Bullock, R Burke, D Chappie, W Davis, W Evoy, J Fentress, C Fowler, M Turvey, P Fraser, S Grillner, A Herman, G Horridge, J Lies, S Kater, B Granzow, F Krasne, W Kristan, J Weeks, J Larimer, E Lewis, R Llinasand, M Bunge, J Lynch, } Mccarthy, D Rosenbaum, P Stein, Y Tsukada, C Wiersma, J Wine, R Zucker, Dalbir Bindra, With Commentary, M Bitterman, A Black, R Bolles, D Booth, A Catania, D Dennett, R Epstein, J Flynn, C Gallistel, R Gilbert, E Hilgard, S Hulse, F Irwin, H Jenkins, H Kendler, P Killeen, M Klingsporn, F Logan, N Mackintosh, J Mazur, E Menzel, O Mowrer, E Murray, D Navarick, J Notterman, K Pribram, J Rosenblatt, T Ryan, K Salzinger, S Soltysik, A Staats, D Stein, R Teevan, E Von Glasersfeld, J Warren, E Wasserman, R Wong, W Wood, Zenon Pylyshyn, M Arbib, M Atherton, L Cohen, S Cushingand, N Hornstein, Z Domotor, H Dreyfus, H Goodluck, L Harmon, J Haugeland, Pvj Hayes, P John Son-Laird, K Leibovic, D Lenat, C Longuet-Higgins, J Mcdermott, A Newell, A Ortony, J Pascual-Leone, R Rodger, R Schank, T Simon, A Sloman, N Sutherland, M Treisman, S Ullman, W Weimer, Y Wilks, P Roland, W Chappie, J Dickinson, J Duysens, G Loeb, P Dyhre-Poulsen, H.-J Freund, G Goodwin, R Granit, P Grigg, A Iannone, J Kelso, M Levitt, B Libet, D Mccloskey, J Millar, G Mpitsos, L Pubols, T Roberts, W Shebilske, G Somjen, K.-H Sontag, J Stein, J Stevens, C Trevarthen, E Walsh, M Wells, M Wiesendanger
Journal: Behavioral and Brain Sciences (1978)

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Crystallization of Human Cyanmetmyoglobin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errata
Journal: BMJ (1898)

spondent in a man who was bleeding-furiously from a sloughing cnancre which had eroded a branch of the dorsalis penis artery; free local manipulation was necessary, the condition being urgent.ln this case he tookt the risk, using HgCI2 lotion freely.The circumstances of the woman's case forbade the purchase of special gutta-percha gloves, his experience of which, moreover, is not encouraging.*** We have referred this question to a surgeon of great experience, who has been good enough to favour us with the following opinion: " I should regard the risk, if a man anoints:his hands well, and washes well afterwards, as infinitesimally small.A surgeon is bound, when his patient's interest demands it, to encounter such risks, and I should regard a man as unfit for his profession who should shirk them.If he hesitates, surely he should explain his fears to his patient, and let her seek the assistance of a more courageous surgeon.
PURE FOOD BILL.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal