tbuckley/cabot-search huggingface dataset:
A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
Authors: V. A. Miller, P. O'Connor, C. Soh, F. Kabbinavar
Journal: Journal of Clinical Oncology (2009)

LBA8002 Background: B when added to chemotherapy, and E alone, each lead to improved survival in the treatment of patients (pts) with NSCLC (Sandler et al, NEJM 2006, 355:2542–2550; Shepherd et al, NEJM 2005, 353:123–132). Pre-clinical and clinical data (Herbst, J Clin Oncol 2007, 25: 4743–4750) suggest that the combination of B and E may improve the efficacy of NSCLC treatment. This potential was demonstrated in the BETA (B in combination with E compared with E alone for treatment of advanced NSCLC after failure of standard first-line chemotherapy) trial, a phase III trial in which progression free survival (PFS) was improved for patients treated with B + E (Hainsworth, Thoracic Oncol 2008, 3(11) Supp. 4:S302). Methods: The ATLAS study was designed to evaluate B + E (150 mg daily) versus B alone, following B + platin-containing doublet chemotherapy, in pts with stage IIIb/IV NSCLC. Enrolled pts were B-eligible, including pts with treated brain metastases, and pts anticoagulated with low molecular weight heparin(s). Pts with peripheral and/or extra-thoracic squamous tumors were also eligible. Pts received 4 cycles of B (15 mg/kg every 3 weeks) with chemotherapy. Pts who had not experienced disease progression (DP) or significant toxicity were then randomized to receive B + E or B + placebo (P). The primary objective of ATLAS was to compare PFS in pts receiving B + E versus B + placebo. Secondary objectives included the assessment of safety, and overall survival. A data safety monitoring committee (DSMC) monitored safety and efficacy. Results: 1,160 patients were enrolled and 768 randomized from May 2005 to May 2008. The DSMC recommended stopping the trial at the second planned interim efficacy analysis, because it met the primary endpoint. The median PFS after randomization was 4.8 mos for (B + E) vs. 3.7 mos for (B + P), HR= 0.722 (95% CI: 0.592–0.881), p = 0.0012. The safety profile for B + E was consistent with known profiles for B and E. Conclusions: E added to B treatment after chemotherapy with B significantly improves the PFS of patients treated in the first-line setting for locally advanced, recurrent, or metastatic NSCLC. [Table: see text]
How Useful Are Automated External Defibrillators?
Authors: S. P. Lovinger
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allogeneic Hematopoietic Cell Transplantation after Fludarabine and 2 Gy Total Body Irradiation for Relapsed and Refractory Mantle Cell Lymphoma.
Authors: Michael B. Maris, Brenda M. Sandmaier, Barry E. Storer, Thomas Chauncey, Monic Jain Stuart, Richard T. Maziarz, Edward Agura, Amelia A. Langston, Michael Pulsipher, Rainer Storb, David G. Maloney
Journal: Blood (2004)
The FitzPatrick Lectures ON MEDICINE IN ENGLAND DURING THE REIGN OF GEORGE III: Delivered before the Royal College of Physicians of London
Authors: A. Chaplin
Journal: BMJ (1917)

The'thorax and abdomeli were examined post niortem.The heart wvas-small, and the foramenl ovale uincelosed.The ltngs were apparently normal and' air-containing, light pink, and floated easily.The conlditioln of thle liver anld intestines was as descrilbed above.There was, however, commenicing adhesive peritoniitis.On exploring the abdomihal cavity proper, n1o kidlneys could be felt in, the usual place in the loins, but two large kidnieys with large suprarenal bodies attacihed were-found pushed up right uinder thie displhragm, occupying in fact the position of iLore normal liver.Thie -spleeni wtas well developed'.No gall bladder could be found.The testes were very smatl ond oceupied a position corresfjonding to the normal ovaries.The bladder was small anid very thick-walled; on cutting into it hardly anycavity was visible, and it contained not more than a drop or two of fluid.
The prediction of immunity to coronary heart disease
Authors: R. H. Rosenman
Journal: JAMA (1966)

The occurrence of new coronary heart disease (CHD) in the presence of below average serum levels of lipids and lipoproteins was studied during a 4 1/2-year period of observation of 2,998 normotensive men, aged 39 to 59 years at intake into a prospective, epidemiological investigation. It was found from this study that the normotensive, middle-aged man with the<i>fully developed</i>type B behavior pattern was essentially immune to the development of clinical CHD if he exhibited a serum cholesterol level less than 226 mg/100 ml, a serum triglyceride level less than 126 mg/100 ml, or a serum β-/α-lipoprotein ratio less than 2.01, singly or in combination.
Comparison of glyceraldehyde-3-phosphate dehydrogenase and 28S-ribosomal RNA gene expression in human hepatocellular carcinoma
Authors: Y Gong
Journal: Hepatology (1996)

The gene responsible for transcribing glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is commonly used as a reporter gene to estimate the amount of RNA present in Northern analyses. However, recent data suggest that GAPDH gene expression may vary with the extent of cell proliferation and differentiation. 28S-ribosomal RNA (28S-rRNA) has also been employed to normalize Northern blots prepared with total RNA. In the present study, we compared the expression of GAPDH messenger RNA (mRNA) with 28S-rRNA by Northern blot analyses in human hepatocellular carcinoma tissues (HCC) and adjacent non-HCC tissues from eight patients with chronic viral hepatitis-induced cirrhosis and normal liver tissue from eight healthy control subjects. The results of the study revealed that GAPDH mRNA levels in HCC were significantly higher (14×-16×) than those in adjacent non-HCC and normal liver tissues. Conversely, 28S-rRNA levels did not vary among HCC, adjacent non-HCC, and normal liver tissues. We also demonstrated that the 28S-RNA signal was proportional to the amount of RNA loaded. These findings indicate that 28S-rRNA, rather than GAPDH mRNA, should be used as RNA loading controls for Northern blot analyses involving HCC and nontumor tissues. The findings also raise the possibility that GAPDH mRNA gene expression might serve as a diagnostic indicator for human HCC.
Provide more consultants out of hours, acute trusts told
Journal: BMJ (2010)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Provide more consultants out of hours, acute trusts told Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
COURSE OF STUDY.
Authors: W. A. EVANS
Journal: JAMA (1900)

In preparing this paper I have had before me the time cards of several of the very best dental schools that this country has produced. Some of these have rather nominal university connection; some have considerable university control; some have close medical school affiliations. Such figures as I use are obtained by averaging those derived from these schedules. The question is not one of condemnation of the dental course as now existing. Lest there be some misunderstanding in this regard, I hasten to say that the average dental course is better than the average medical course. I will even state the matter more strongly: For the average dental student any good dental course is better than is the best medical course for the average medical student. Unquestionably the past demand has been, and the present one is, for a dentist who can meet the ordinary questions that arise in the
" Collateral Associations."
Authors: Albert L. Gihon
Journal: JAMA (1893)

<h3>To the Editor of the Journal of the American Medical Association:</h3><h3>Sir:</h3> —Referring to the editorial on " Collateral Associations" in your issue of January 21, I may be permitted to remind you that for several years I have been advocating the very subject of your writing—the encouragement and facilitation by the American Medical Association of the meeting of these collateral organizations in connection with its own annual session. You say these "societies would very greatly enhance their own usefulness and prosperity by arranging their place of meeting to correspond with the same place, and either the week before, or after, that of the American Medical Association." But very few men in the profession can afford to sacrifice the time or incur the expense of two continuous weeks of attendance as you propose. The American Academy of Medicine has tried the experiment of meeting on the Saturday and Monday immediately preceding
Borrelia in Boston
Authors: R. L. Goodman
Journal: JAMA (1969)

A 26-year-old, intermittently febrile woman returned from the West to Boston, where a diagnosis of relapsing fever was established. The infection should be considered in travelers from the western states who manifest recurrent fever and weakness, often with splenomegaly and rash. The diagnosis is most directly established by demonstrating spirochetes in properly stained blood smears during the febrile periods.
Massachusetts Medical Society
Authors: George E. Morris
Journal: New England Journal of Medicine (1960)

TOXIC HAZARDS*Chrome Hazards†The three major chrome hazards in industry are exposures to chromic acid mists, dichromates and basic chromic sulfate. Chromic acid (chromium trioxide; chromic anhydride) has multiple uses, in chromium plating, and anodizing, as a catalyst and oxidizing agent, as a textile mordant, in process engraving, ceramic glazes, colored glass, metal cleaning, inks and paints and in the preparation of leather-tanning chemicals.1 Chromic acid itself is so well known for its harmful effects that workers are usually very careful not to come into direct contact with it, and therefore most hazards arise from chromic acid mists. . . .
THE COMMISSION ON MEDICAL EDUCATION
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel T-shaped linear-stapled intrathoracic esophagogastric anastomosis for minimally invasive Ivor Lewis esophagectomy.
Authors: YiNan Dong, Liang Zhang, Nan Sun, Yi Ren, YongYu Liu
Journal: Journal of Clinical Oncology (2015)

e15071 Background: Linear stapler is increasingly used for the grastroesophgeal anastomosis in minimally invasive esophgeal cancer surgeries; however, it is more commonly used in cervical delta anastomosis, less in totally thoracoscopic Ivor Lewis esophagectomy for esophgeal cancer. A standardized rapid linear stapler based gastroesophgeal anastomotic technique remains to be developed. Methods: Here we report a new technique for the endoscopic gastroesophgeal anastomosis that is completed just with a liear stapler (Ethicon Flex 60). In this technique, a linear stapler is first fired upward to establish the side to side anastomosis of the esophagus and stomach. This creates the anterior and posterior wall of the anasmotic site. The linear stapler is then fired along the extension line of the gastric conduit, to complete the anastomosis and at the same time resect the lesser curvature of the stomach and the esophageal cancer. Upon completion, the anastomotic plane is axial, and contains a superior edge, inferior edge, and anterior edge. Results: By the middle January 2015, we have performed the minimally invasive Ivor Lewis esophgeactomy with this anastomosis for 16 esophageal cancer patients. We are following these patients, and the longest follow up time is about 11 month and the shortest is 17 days. None of these patients has had any anastomotic bleeding, leak, or stenosis. Conclusions: This new technique is less restricted by the limited space during minimally invasive Ivor Lewis procedure. The anastomotic technique is easy to perform and appears to be reliable, safe and effective judging from our limited clinical experience up to this date. (We have drawn seven excellent pictures for the whole surgical process, but nowhere to submit them. )
General Criteria for Assessing the Evidence for Carcinogenicity of Chemical Substances: Report of the Subcommittee on Environmental Carcinogenesis, National Cancer Advisory Board12
Journal: JNCI Journal of the National Cancer Institute (1977)

The evaluation of the potential human hazards of a given agent must be individualized in terms of the chemical and metabolic aspects of the agent, its intended use, and the data available at the time. An agent is carcinogenic in man if it increases the incidence of malignant neoplasms, or a combination of benign and malignant neoplasms in humans to levels that are significantly higher than those in a comparable group not exposed to the agent. Types of evidence suggesting that an agent is carcinogenic include neoplastic response directly related to exposure, and incidence and mortality differences related to occupation exposure or geographic regions. Negative epidemiologic data may not establish the safety of suspected materials. The carcinogenicity of a substance is also established when the administration to groups of animals in adequate experiments results in increases in the incidence of 1 or more types of malignant neoplasms in the treated compared to the control groups. The demonstration that the occurrence of neoplasms is dose-dependent also qualifies as a positive result. If a substance is found to induce benign neoplasms it should be considered a potential health hazard. Some short-term or in vitro tests which appear promising include assays for the induction of DNA damage and repair, mutagenesis in bacteria, yeast, and neoplastic transformation of mammalian cells in culture. Quantitative extrapolation from animal studies to evaluate human risks is not a clear science; each case must be considered individually. When a compound has been proven carcinogenic there remains the question of the extent to which the possible risks to man are counterbalanced by the possible benefits of the substance.
Causes of impotence
Authors: Arthur Osteen
Journal: JAMA (1983)

<h3>In Reply.—</h3> The AMA Board of Trustees Report on Health Manpower, adopted at the interim meeting of the House of Delegates in 1981, opposes centralized regulation of the number of physicians and favors, instead, reliance on market mechanisms. Several medical schools recently have reduced the sizes of their entering classes and others are discussing doing so, an indication that market mechanisms do work, given time. The best information available indicates that US citizen graduates of foreign medical schools entering residency programs at present do not exceed 2,500 per year, the number suggested as acceptable by Dr Louria. The total number of foreign medical graduates entering practice in the United States, while more than 2,500 per year, has declined in recent years. At present, the majority of alien foreign medical graduates immigrating to the United States are admitted as refugees or relatives of US citizens, who are, incidentally, physicians. Enacting laws
A new vector, based on the PolII promoter for the U1 snRNA gene, for the expression of siRNAs in mammalian cells
Authors: M DENTI
Journal: Molecular Therapy (2004)

Several vectors for the induction of RNA interference in mammalian cells have been described, based mainly on polIII-dependent promoters. They transcribe short hairpin RNAs (shRNA) that, after being processed into short interfering RNAs (siRNAs), mediate the degradation of the target mRNA. Here, we describe the construction of a new siRNA-expressing vector (psiUx) based on the strong and ubiquitous polII-dependent promoter of the human U1 small nuclear RNA (snRNA) gene. In psiUx, the only constraint for the shRNA sequence is a purine at position +1, since specific 3′-end formation is achieved by a box element located downstream of the transcribed region. Several constructs were designed against the lamin A/C target. Depending on the structure of the shRNA transcribed, a preferential or exclusive accumulation of the antisense strand is obtained, thus avoiding possible nonspecific targeting by the sense strand. In all cases tested, very effective siRNAs were produced, thus providing a proof-of-principle that a snRNA-type polII promoter can be used for the expression of siRNAs. We show that psiUx ensures high levels of expression and efficient knock down of the target gene also in stable cell lines.
Determination of Sulfur Trioxide in Engine Exhaust
Authors: Dean R. Arnold
Journal: Environmental Health Perspectives (1975)

Sulfur trioxide in the exhaust gas of an internal combustion engine is removed and concentrated by absorption in a solution of 80% isopropyl alcohol, which quantitatively absorbs it and inhibits the oxidation of any sulfur dioxide which may be absorbed. The absorbed sulfur trioxide (sulfuric acid) is determined by an absorption titration by using barium chloride as the titrant and thorin as the indicator. The sulfur dioxide content of the exhaust is measured continuously by means of a DuPont Model 411 ultraviolet photoanalyzer.
Phenolphthalein Highlights NTP Bioassay Review
Journal: Environmental Health Perspectives (1996)

Newsprocess, Moore's group first wrestled with the issue of balancing bias-of experts clearly stating their opinions, and then working toward consensus.The group also tackled the problem of how to quantitatively express exposures in the context of a dose that -may cause adverse effects.However, the core of their activity "looked at all human and animal data to first come up with a 'sufficiency' type of judgment.Then we went into the general toxicology database to look at types of effects and consistency of those effects.These data sets were then integrated to come up with a statement that expresses a judgment as to the composite datas relevance to humans," says Moore.The group has already published one paper on the effects of lithium on repro- duction and development that found that fetal development can be affected by women taking therapeutic doses of lithi- um, but that other sources of exposure to lithium do not appear to result in levels that pose a health risk.Their second study, on boric acid, is completed and seeking publication.The IEHR prototype would serve as a good model for Shelby's center, Moore concludes.
Sectarian Medicine
Authors: Norman Gevitz
Journal: JAMA (1987)

IN<i>THE Devil's Dictionary</i>, Ambrose Bierce defined a "homeopath" as "the humorist of the medical profession."<sup>1</sup>To Bierce, this practitioner with his peculiar notions regarding the selection and administration of drugs may have been an unintentionally funny figure, but to orthodox physicians who combated these opponents through the years, homeopathy was anything but a laughing matter. Neither were other sectarian rivals who have flourished in the United States during the past 150 years. The term "sect" has been applied to those groups (whether inside or outside the orthodox medical tradition) who have challenged the legitimacy and value of accepted therapeutic principles and practices. Such groups have championed the use of alternative modes of healing based on a set of doctrines that they initially regard as laws. Given their radical beliefs and approaches, these sectarians have had to form separate institutions and associations to support their continued existence and growth.
PUBLIC MISREPRESENTATION OF CONGRESS.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal