tbuckley/cabot-search huggingface dataset:
Highlights from the Literature
Authors: K. Aldape, W. Pope, J. Huse, D. Schiff, G. Zadeh
Journal: Neuro-Oncology (2013)

Chordomas are rare and indolent bone tumors that arise in the skull base and mobile spine. Distant metastases occur in >20% of cases, but morbidity and mortality are mainly related to local relapses that affect the majority of patients. Standard chemotherapy has modest activity, whereas new targeted therapies (alone or in combination) have some activity in controlling disease progression. However, the scarcity of preclinical models capable of testing in vivo responses to these therapies hampers the development of new medical strategies.In this study, 8 chordoma samples taken from 8 patients were implanted in nude mice. Four engrafted successfully and gave rise to tumor masses that were analyzed histologically, by means of fluorescence in situ hybridization and biochemical techniques. The data relating to each of the mouse tumors were compared with those obtained from the corresponding human tumor.All 4 engraftments retained the histological, genetic and biochemical features of the human tumors they came from. In one epidermal growth factor receptor(EGFR)-positive xenograft, responsiveness to lapatinib was evaluated by comparing the pre- and post treatment findings. The treatment induced a low-level, heterogeneous switching off of EGFR and its downstream signaling effectors.Overall, this model is very close to human chordoma and represents a new means of undertaking preclinical investigations and developing tailored therapies.
Nuclear Hematology
Authors: E. B. Silberstein
Journal: Clinical Nuclear Medicine (2008)

One of the first areas of patient care to which the specialty of nuclear medicine contributed was hematology, when phosphorus-32 was employed by John Lawrence, MD at the Donner Laboratory, University of California at Berkeley, to treat leukemia and polycythemia vera. Hematologic techniques developed over a half-century ago can quantitate the survival and localize the site of destruction of erythrocytes and platelets with remarkable sensitivity. Measurement of the erythrocyte volume (EV) and plasma volume (PV) remains the cornerstone of any diagnostic algorithm for determining the cause of an elevated hematocrit/hemoglobin. And yet utilization of these techniques is diminishing.
NOTES AND OBSERVATIONS ON SOME OF THE MORE REMEDIABLE CASES OF DEAFNESS
Authors: C. Holthouse
Journal: BMJ (1855)

COMUNCATIONS.aU led X casew, nor the antdt.I have no doubt that w ha suffee fom srlet feve.C ia v. Maer B. had carlet fever when a child, in which he nearly died from ear and brain disease.Some months after recovery, I saw him, then perfectly deaf.The membrna tyimpami were both removed by ulceration, as well as the ossicula.A portion of cochlea was likewise shown me, which had escaped from the ear-copious dis- chwrUe from a spongy mucous membrane.The membrane was unproved; otorrhoea lessened, and at length removed.He gradually lost his speech, and is now being educated as a deaf-dumb.CASB VIII.A physician writes me as follows:-" MJy two children, aged respectively 11 and 13, were six weeks past attacked with scarlatina anginosa, very intense and protracted; the throat affection accompanied with severe inammation of the mucous lining of the mouth and nostrils, and spreading to the nasal ducts, and affecting the eyes.Habeat haust.cathart.omni miiane.July 15th.The leech-bites bled freely, and the pa- tient was much relieved.He felt lighter in the head, and slept better last night than he had done since the attack.
Multiple opportunistic infections and neoplasms in the acquired immunodeficiency syndrome
Authors: G. P. Wormser
Journal: JAMA (1985)

The articles by Fischl et al<sup>1</sup>and Burkes et al<sup>2</sup>that appear elsewhere in this issue nicely illustrate the scope of infectious and neoplastic complications found in the acquired immunodeficiency syndrome (AIDS). Just two patients were reported, but between them they had no fewer than nine different infections and two malignancies, including human T-cell lymphotropic virus (HTLV-III) infection, oral candidiasis,<i>Pneumocystis carinii</i>pneumonia, cytomegalovirus infection, fungal brain infection,<i>Toxoplasma</i>brain abscesses, tuberculosis, cysticercosis, Epstein-Barr virus infection, Kaposi's sarcoma, and non-Hodgkin's lymphoma. Convincing evidence now exists that the cause of AIDS is a retrovirus, HTLV-III, and that this infection may be associated with a profound and progressive cellular immunodeficiency state.<sup>3</sup>Other data also indicate the possibility of impaired humoral defenses, but in adults, so far, this has led to comparatively few clinical sequelae.<sup>4</sup>Serious opportunistic infections and/or Kaposi's sarcoma dominate what appear to be the later
Treatment Of Acute Edema Attacks In Hereditary Angioedema With A Bradykinin Receptor-2 Antagonist (Icatibant)
Authors: B. Grundt, K. Bork, J. Frank, P. Schlattmann, J. Nussberger, B. Rosenkranz, L. Dong, J. Knolle, W. Kreuz
Journal: Journal of Allergy and Clinical Immunology (2007)
Tularemia: History, Pathology, Diagnosis and Treatment.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICINAL PLASTERS.
Authors: JOHN V. SHOEMAKER
Journal: JAMA (1893)

In most diseases involving the skin both constitutional and local treatment is needed in order to effect a cure or improvement. Topical remedies may be applied in different forms and it is often a question whether a powder, a solution, an ointment, paste or plaster is calculated to afford most speedy relief. Plasters possess certain advantages which render them appropriate means of dealing with some varieties of skin diseases. They are especially adapted to the treatment of chronic and localized conditions. In the subacute and formative stages of some maladies they are also of value. Plasters are composed of mixtures which are solid at ordinary temperatures but which soften somewhat when kept in contact with the skin, to which they closely adhere. The medicated material is spread evenly upon some fine texture, very fine muslin being usually employed. Plasters constitute an efficient protection of the diseased area against the atmosphere.
Association between geographic access to cancer care and receipt of chemotherapy: Geographic distribution of oncologists and travel distance.
Authors: Chun Chieh Lin, Suanna S. Bruinooge, Kelsey M. Kirkwood, Christine Cecilia Olsen, Dean F. Bajorin, Ahmedin Jemal, Sharon Hermes Giordano, Michael Goldstein, Beverly Ashleigh Guadagnolo, Michael P. Kosty, Shane Hopkins, James B. Yu, Anna Arnone, Amy E. Hanley, Stephanie Stevens, Dawn L. Hershman
Journal: Journal of Clinical Oncology (2015)

e17561 Background: Geographic access to care may be associated with receipt of chemotherapy but has not been fully-examined. This study sought to evaluate association between density of oncologists and travel distance to receipt of adjuvant chemotherapy for colon cancer within 90 days of colectomy. Methods: Patients in the National Cancer Data Base with stage III colon cancer, diagnosed between 2007 and 2010, and aged 18 to 80 were selected. Generalized Estimating Equations clustering by Hospital Service Area (HSA) was conducted to examine the association between geographic access and receipt of oncology services, controlling for patient sociodemographic and clinical characteristics. Results: Of 34,694 patients in the study cohort, 75% of them received adjuvant chemotherapy within 90 days of colectomy. Compared to travel distance < 12.5 miles, patients who travelled 50-249 miles (OR 0.89, p = .026) or ≥ 250 miles (OR 0.37, p < .001) had decreased likelihood of receiving adjuvant chemotherapy. Density level of oncologists was not statistically associated with receipt of adjuvant chemotherapy (low vs. high density: OR 0.97, p = .668). When stratifying analyses by insurance status, non-privately-insured patients who resided in areas with low density of oncologists were less likely to receive adjuvant chemotherapy (OR 0.86, p = 0.04). Conclusions: Increased travel burden was associated with a decreased likelihood of receiving adjuvant chemotherapy for patients with stage III colon cancer, regardless of insurance status. Patients with non-private insurance who resided in low-density oncologist areas were less likely to receive adjuvant chemotherapy. If these findings are validated prospectively, interventions to decrease geographic barriers may improve the timeliness and quality of colon cancer treatment.
Biological Evaluation of Silicone Rubber for Surgical Prosthesis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"FITNESS" IN DISEASE
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-Range Study Of Heart Disease
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leishmaniasis y Blastomicosis en America.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMERICAN COLLEGE OF PHYSICIANS
Authors: FRANCIS MARION POTTENGER
Journal: Annals of Internal Medicine (1931)

Editorial1 May 1931AMERICAN COLLEGE OF PHYSICIANSFRANCIS MARION POTTENGER, Ph.B., Ph.M., A.M., M.D., LL.D.FRANCIS MARION POTTENGER, Ph.B., Ph.M., A.M., M.D., LL.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-11-1481 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBorn, 1869; Ph.B., Ph.M., A.M., LL.D., Otterbein College, Westerville, Ohio; M.D., Cincinnati College of Medicine and Surgery, 1894. Postgraduate study at New York Polyclinic and European Clinics, including Vienna, Berlin and London. Lecturer on Diseases of the Chest and Climatology, University of Southern California College of Medicine, 1903-04; Professor of Clinical Medicine, same, 1905-09; Professor of Diseases of the Chest, College of Physicians and Surgeons of the University of Southern California, 1914-20; President and Medical Director, The Pottenger Sanatorium; Member, Board of Trustees, Otterbein College; Member, Phi Rho Sigma and Pi Gamma Mu Fraternities; Member and ex-President, Los Angeles County... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Monrovia, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1931Volume 4, Issue 11Page: 1481-1481KeywordsSurgeonsSurgeryThorax ePublished: 1 December 2008 Issue Published: 1 May 1931 PDF downloadLoading ...
Laryngoscope Detects Cancer Earlier
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic Diagnosis and Treatment of Upper Gastrointestinal Tumors
Authors: M.  Polkowski
Journal: Endoscopy (2004)

This year’s Digestive Disease Week (DDW) saw the presentation of more than 70 studies focusing on endoscopic diagnosis and treatment of precancerous conditions and tumors in the upper gastrointestinal tract. For reasons of space, only a handful of these are discussed in detail in this review [1] [2] [3] [4] [5] [6] [7] [8] [9]; the remaining are summarized in tabular form or simply mentioned in the text. The selection process was facilitated by the fact that the majority of studies were single-arm and retrospective - prospective or comparative studies, quite apart from randomized trials, were notable exceptions. Endoscopic diagnosis and treatment of Barrett’s esophagus were covered in a separate DDW report [10].
Changes in serum lipid peroxide after transarterial embolization for patiens with hepatocellular carcinoma 2nd Department of Medicine, Toho University, Tokyo, Japan
Journal: Hepatology (1995)

Purpose: The objective of this study was to evaluate the ability of Doppler tissue imaging (DTI) to localize the ventricular emergence site of accessory atrioventricular pathways (Wolff-Parkinson-White syndrome). Methods: Thirty-three patients were studied prospectively by Doppler tissue imaging (128XP and Sequoia 256 echocardiographic systems; Acuson, Mountain View, Calif) before investigation of Wolff-Parkinson-White syndrome and after radiofrequency ablation of the accessory pathways. The normal appearance of the ventricular contractions was defined in a group of 10 control subjects. The preexcitation zone was determined as a zone of maximum acceleration in “DTI acceleration mode” or as a coded contraction zone in “DTI velocity mode,” at the time of the delta wave or before the onset of the QRS complex. Results: The earliest ventricular activation site was correctly localized for 12 of the 15 left-sided pathways (8 anterior or anterolateral, 2 lateral or posterolateral, 2 inferior). When wall motion abnormalities were detected in the left ventricle by DTI, the left-sided localization was confirmed by electrophysiologic exploration. For the right-sided pathways, the localization was correct in only 4 of 11 cases (3 posteroseptal and 1 anterolateral). After effective ablation in all patients, the abnormalities corresponding to the electrophysiologic data disappeared totally in only 11 of 16 patients. Conclusion: In the presence of Wolff-Parkinson-White syndrome, DTI localizes contraction abnormalities associated with early activation of a part of the ventricle. However, the interpretation of the images remains difficult because the normal coding of the contraction of the ventricular walls depends on the incidence for which they are investigated. This noninvasive examination seems to be an effective tool for localizing the left-sided accessory pathways of the left ventricle, in particular in the anterior, anterolateral, or inferior walls. (J Am Soc Echocardiogr 2000;13:995-1001.)
PARETIC DEMENTIA AND LIFE INSURANCE.
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
This Week in &lt;EMPH&gt;JAMA&lt;/EMPH&gt;
Journal: JAMA (2006)

William H. Maisel, MD, MPH; Megan Moynahan, MS; Bram D. Zuckerman, MD; Thomas P. Gross, MD, MPH; Oscar H. Tovar, MD; Donna-Bea Tillman, PhD, MPA; Daniel B. Schultz, MD
Reply
Authors: D. R Mack, A. M Griffiths
Journal: Gut (1990)

tion with H pylori (69/70=99%) compared with the smaller risk (RR=8) with antral infection with H pylori (85/96= 89%).'In our series" the frequency of duodenal ulcer in patients with H pylori in their duodenum was double the frequency of ulcers in the duodenums of patients with H pylori in their antra, which is why we suggested 'that duodenal H pylori may be more closely cor- related with duodenal ulceration than is antral infection'.2
International Conference on Advances in Regional Cancer Therapy '87
Journal: JNCI Journal of the National Cancer Institute (1987)

International Conference on Advances in Regional Cancer Therapy '87 Get access JNCI: Journal of the National Cancer Institute, Volume 78, Issue 4, April 1987, Page 785, https://doi.org/10.1093/jnci/78.4.785-d Published: 01 April 1987