tbuckley/cabot-search huggingface dataset:
Mesangiocapillary glomerulonephritis.
Authors: G D'Amico, F Ferrario
Journal: Journal of the American Society of Nephrology (1992)

The clinical and histological features of idiopathic mesangiocapillary glomerulonephritis (MCGN) have been reviewed, with a survey of the most recent literature, including the retrospective analysis of the data of the Italian Study Group of Renal Immunopathology on 368 patients. In both major types of MCGN, six morphological variants have been characterized (classical MCGN, nodular MCGN, exudative MCGN, focal segmental MCGN, MCGN with massive deposits, and crescentic MCGN) that have different etiologic, pathogenetic, or clinical outcome correlates. Actuarial renal survival 10 yr after renal biopsy has been calculated with life-table analysis to be 60 to 65% in type I MCGN, without significant differences between treated and untreated patients; none of the therapeutic regimens tested up to now for this disease have been independently demonstrated to be efficacious. As for the pathogenesis, the interrelationships between the three mechanisms that contribute to the development of the morphological features of the disease (accumulation of electron-dense deposits on the subendothelial side of the glomerular basement membrane or within the glomerular basement membrane; mesangial proliferation and peripheral interposition; and inflow of inflammatory cells, mainly monocytes) have been discussed, and the role of hypocomplementemia and circulating nephritic factors (NFa and NFt) has been analyzed. Available evidence suggests that MCGN is an immunocomplex-mediated disease, the deposition of immune deposits being the initiating phenomenon, whereas the morphologic changes and complement system activation are secondary events.
Labyrinth and Equilibrium.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lomustine treatment of metastatic renal cell carcinoma
Authors: A. Mittelman
Journal: JAMA (1973)

The efficacy of lomustine (CCNU) therapy in metastatic renal cell carcinoma was studied in 23 patients. Only 20 of these cases could be evaluated, and, of these, four showed an objective remission lasting from three to six months. Hypercalcemia was controlled, pulmonary and soft tissue metastases regressed, and recalcification of lytic osseous metastases was noted. The condition of two other patients has been stable for more than six months. Minimal toxicity, such as transient early nausea and vomiting, was associated with drug administration. Moderate thrombocytopenia and mild leukopenia were seen in one third of all patients. Lomustine merits further clinical use in the treatment of advanced renal cell carcinoma.
Book Reviews
Authors: Giovanni A. Fava, G. Ba, E. Fava, I. Carta, M. Clerici, S. Albonetti, R. Papa, G. Penati, G. Invernizzi, James D.A. Parker, Graeme J. Taylor, Michael Bagby, Robert Kellner, Juan Hernandez, Dorothy Pathak, Töres Theorell, Jenifer Wilson-Barnett, L.G. Sobrinho, J.M. Almeida-Costa
Journal: Psychotherapy and Psychosomatics (1992)
Longer-term cardiac safety and outcomes of dose dense (dd) doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T) and trastuzumab (H) with and without lapatinib (L) in patients (pts) with early breast cancer (BC).
Authors: Neil M. Iyengar, Patrick Glyn Morris, Sujata Patil, Carol Chen, Alyson Abbruzzi, Robert James Lehman, Richard Steingart, Kevin C. Oeffinger, Nancy U. Lin, Beverly Moy, Steven E. Come, Eric P. Winer, Larry Norton, Clifford Hudis, Chau T. Dang
Journal: Journal of Clinical Oncology (2013)

167 Background: The addition of H to chemotherapy has improved outcomes in HER2-positive early BC. This approach is associated with (w/) an increased risk (&lt;4%) of congestive heart failure (CHF). Dose-dense (every 2 weeks) anthracycline-taxane therapy (Rx) improves survival compared to the every 3 week schedule and can be combined w/ anti-HER2 Rx w/ no increased risk of cardiotoxicity up to 36 months. Here we report the incidence of NYHA Class III/IV CHF in 2 phase II studies with longer follow-up. Methods: We conducted a retrospective review of pts w/ HER2 + early stage BC treated at MSKCC and DFCI on two trials: In trial A - pts received dd AC (60/600 mg/m 2 ) x 4 → T (175mg/m 2 ) x 4 (w/ pegfilgrastim) w/ H x 1 year. Trial B differed w/ use of weekly T (80mg/m 2 ) x 12 and the addition of L (1000mg orally daily) x 1 year. Left ventricular ejection fraction (LVEF) was prospectively assessed by a multi-gated acquisition scan serially throughout Rx. Results: Trial A enrolled 70 pts and Trial B enrolled 95 pts w/ the median age of 46 years (range 27-73 years). Overall, the 5-year distant disease-free survival (DDFS) for trials A and B is 92% (95%Cl; 83-97%) and 89% (95%CI; 81-94%), respectively. The baseline median LVEF was 68% (range 52-81%). In total, 28 of 165 (17%) pts had pre-existing hypertension. Now at a median follow-up of 84 and 57 months respectively, only one (1.4%, 95%CI; 1.36-7.7%) and 4 (4.2%, 95%CI; 4.2-10.4%) pts developed CHF. Since our earlier report, 1 additional CHF event occurred (Trial B) at month 44. Conclusions: Longer follow-up of these 2 studies demonstrate that dd AC → TH with or without L is associated w/ a low risk of CHF. This is consistent w/ the long-term cardiac toxicity reported from the randomized phase III studies of H w/ conventionally scheduled anthracycline-based regimens (with or without taxanes). DDFS outcomes are also encouraging. Clinical trial information: NCT00591851 and NCT00482391.
Rupture of aortic aneurysm into inferior vena cava
Authors: M. Glasser
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Rupture of an abdominal aortic aneurysm into the inferior vena cava is a rare occurrence usually accompanied by dramatic symptoms. Of 11 patients described by Beall et al,<sup>1</sup>all except two had pain in the abdomen, back, or lower extremities; eight had swelling of the lower extremities; nine had a pulsating abdominal mass; ten had an abdominal murmur; and only four had cardiac decompensation. The intriguing aspects of the case presented here are the few symptoms, the conspicuous absence of pain, and the scarcity of physical findings during the early stages of the disease. <h3>Report of a Case:—</h3> A 60-year-old man was admitted to the hospital at 10:30 PM on Jan 24, 1967, because of nausea and vomiting, headache, and numbness or cramps in the legs for the past few days. He also complained of insomnia and restlessness. The history was noncontributory. Review of systems revealed
ALKALIS IN THE TREATMENT OF INFLUENZA
Authors: Thomas C. Ely
Journal: JAMA (1918)

<h3>To the Editor:</h3> —Following my recent letter regarding the alkaline treatment of influenza (The Journal, Oct. 26, 1918, p. 1431), I have had repeated inquiries as to the exact technic and details of the treatment. The term "alkaline saturation" seemed too indefinite. When the recent epidemic appeared in Philadelphia. I was studying acidosis in a diabetic patient, using the Marriott apparatus. With acidosis as the admitted cause of death in these influenzal cases, I treated every patient on this theory. I have thought of acidosis first, foremost and always—before the attack if there was a suspicion of the disease, during the attack, and until complete recovery. All other treatment has been secondary to that directed to the acidosis. At the outset and through the attack I have given every patient the three well-known alkalis with which we all combat acidosis—sodium bicarbonate, potassium citrate and the calcium salts in the form
Optic Neuropathies
Authors: Simmons Lessell
Journal: New England Journal of Medicine (1978)

THIS is a review of three disorders — ischemic optic neuropathy, optic neuritis and the infiltrative-compressive optic neuropathies — that present ophthalmically but have systemic implications. Affected patients typically suffer persistent, monocular impairment of one or more of their visual functions (acuity, field, color sense or brightness). It is important to be able to distinguish among these optic neuropathies, and to differentiate them from other disorders that produce similar symptoms. The latter distinction is usually accomplished by physical examination, but distinguishing among the various optic neuropathies is not easily accomplished by physical examination since they share many signs. However, the . . .
Annual Reprint of the Reports of the Council on Pharmacy and Chemistry of the American Medical Association, with the Comments That Have Appeared in The Journal of the American Medical Association
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trimethoprim-sulphamethoxazole in Enteric Fevers
Authors: Z. Farid, A. Hassan, M. F. A. Wahab, W. R. Sanborn, D. C. Kent, A. Yassa, S. E. Hathout
Journal: BMJ (1970)

Clinical improvement was rapid in all 13 patients with enteric fever and one with Brucella abortus infection treated with trimethoprim-sulphamethoxazole. There were no side-effects of the treatment and it was found easy to administer to toxic and delirious patients.
More Blind, Placebo Trials Of Anticoagulant Drugs Urged
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does Alcohol Undergo Combustion in the Human System?
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Three fallacies
Authors: Jonathan E. Adler
Journal: Behavioral and Brain Sciences (2000)

Three fallacies in the rationality debate obscure the possibility for reconciling the opposed camps. I focus on how these fallacies arise in the view that subjects interpret their task differently from the experimenters (owing to the influence of conversational expectations). The themes are: first, critical assessment must start from subjects' understanding; second, a modal fallacy; and third, fallacies of distribution.
Ethical dilemmas of brain failure in the elderly.
Authors: G S Robertson
Journal: BMJ (1983)

Medical ethics has come of age in the past year or two as medical and non-medical people alike have been drawn into discussions of the morality or immorality of possible solutions to immensely complex ethical dilemmas.Abortion is an example of an ethical problem which has been faced and "solved" but which continues to offend even though the ethical codes on abortion have been distilled from years of medical, legal, philosophical, and religious debate.The care of infants born with congenital handicaps has provoked equally strong emotions.Important as these problems are, those posed by our elderly citizens, particularly those with brain failure, are assuming even greater urgency.'The important lesson is that the dilemmas are becoming more predictable.In the elderly they will arise from the combination of reduced premature deaths in the young and middle aged, and a projected increase of some 42% in the number over the age of 85 for the years 1971-91.'In people over 80 the incidence of senile dementia is about 20%, and it is estimated that within the next five years there will be 3000 elderly demented people per 250 000 of the population.'In this age group only 3-8% of cases are likely to have a treatable cause for their dementia4 and the prognosis in this type of brain failure approximates to that of the more malignant forms of cancer.Thus the two year mortality in senile dementia is 50%5 but in the meantime many patients may have socially disturbing symptoms.A study in six old people's homes, designed and staffed to cater for the physically dependent elderly, has shown that half of the residents were probably demented and that one third showed evidence of disturbed, interfering, or aggressive behaviour.
The Public Service.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Sookmyung Women’s University JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Ophthalmology
Authors: Edwin B. Dunphy
Journal: New England Journal of Medicine (1946)

IN the past year there have been no outstanding advances in ophthalmology. Two subjects, however, have been selected on the basis of general interest.Penicillin in Ocular InfectionsEnough time has elapsed since the introduction of penicillin to evaluate its efficiency in treating diseases of the eye. The literature abounds with case reports of alleged cures, but in many of these the penicillin has been used along with sulfonamides and other drugs, so that its true therapeutic role is difficult to determine. One fact, however, stands out clearly: penicillin is usually superior to the sulfonamides for several reasons. It is . . .
Laval Médical, Quebec
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Medical Society of the State of Tennessee at its Fifty-first Annual Meeting.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HAEMATO-PORPHYRINURIA
Authors: A. E. Garrod
Journal: BMJ (1922)

<b>Background:</b> Functional breathing disorders may complicate asthma and impair quality of life. This study aimed to determine the effectiveness of physiotherapy based breathing retraining for patients treated for asthma in the community who have symptoms suggestive of dysfunctional breathing. <b>Methods:</b> 33 adult patients aged 17–65 with diagnosed and currently treated asthma and Nijmegen questionnaire scores ⩾23 were recruited to a randomised controlled trial comparing short physiotherapy breathing retraining and an asthma nurse education control. The main outcome measures were asthma specific health status (Asthma Quality of Life questionnaire) and Nijmegen questionnaire scores <b>Results:</b> Of the 33 who entered the study, data were available on 31 after 1 month and 28 at 6 months. The median (interquartile range) changes in overall asthma quality of life score at 1 month were 0.6 (0.05–1.12) and 0.09 (−0.25–0.26) for the breathing retraining and education groups, respectively (p=0.018), 0.42 (0.11–1.17) and 0.09 (−0.58–0.5) for the symptoms domain (p=0.042), 0.52 (0.09–1.25) and 0 (−0.45–0.45) for the activities domain (p=0.007), and 0.50 (0–1.50) and −0.25 (−0.75–0.75) for the environment domain (p=0.018). Only the change in the activities domain remained significant at 6 months (0.83 (−0.10–1.71) and −0.05 (−0.74–0.34), p=0.018), although trends to improvement were seen in the overall score (p=0.065), the symptoms domain (p=0.059), and the environment domain (p=0.065). There was a correlation between changes in quality of life scores and Nijmegen questionnaire scores at 1 month and at 6 months. The number needed to treat to produce a clinically important improvement in health status was 1.96 and 3.57 at 1 and 6 months. <b>Conclusion:</b> Over half the patients treated for asthma in the community who have symptoms suggestive of dysfunctional breathing show a clinically relevant improvement in quality of life following a brief physiotherapy intervention. This improvement is maintained in over 25% 6 months after the intervention.
Cover Image, Volume 40, Issue 5
Authors: Yu‐Hang Yan, Gen Li, Guo‐Bo Li
Journal: Medicinal Research Reviews (2020)

The front cover image is based on the Review Article Principles and Current Strategies Targeting Metallo-β-Lactamase Mediated Antibacterial Resistance by Guo-Bo Li, Gen Li, and Yu-Hang Yan., https://doi.org/10.1002/med.21665.
International Symposium on RNA Viruses and Host Genome in Oncogenesis
Journal: JNCI Journal of the National Cancer Institute (1971)

Journal Article International Symposium on RNA Viruses and Host Genome in Oncogenesis Get access JNCI: Journal of the National Cancer Institute, Volume 46, Issue 1, January 1971, Page 213, https://doi.org/10.1093/jnci/46.1.213 Published: 01 January 1971