tbuckley/cabot-search huggingface dataset:
Mutation of Mouse MAYP/PSTPIP2 Causes a Macrophage Autoinflammatory Disease.
Authors: Violeta Chitu, Johannes Grosse, Andreas Marquardt, Petra Hanke, Carolin Schmittwolf, Lutz Zeitlmann, Patricia Schropp, Bettina Barth, Philipp Yu, Rainer Paffenholz, Gabriele Stumm, Michael Nehls, E. Richard Stanley
Journal: Blood (2005)
PROCEEDINGS OF THE ST. LOUIS SESSION
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Should we routinely recommend a central review of magnetic resonance imaging of the prostate in men with positive mp-MRI? Implication for targeted biopsies
Authors: F. Barletta, A. Stabile, E. Mazzone, V. Cucchiara, C.A. Bravi, G. Rosiello, G. Sorce, F. Pellegrino, L. Nocera, G. Cirulli, G. Basile, R. Leni, E. Zaffuto, G. Brembilla, A. Esposito, G. Gandaglia, N. Fossati, F. De Cobelli, F. Montorsi, A. Briganti
Journal: European Urology (2021)
COMPULSORY REPORTING OF GUNSHOT WOUNDS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Steroid sulfotransferases
Authors: C. A. Strott
Journal: Endocrine Reviews (1996)

I. IntroductionTHE discovery that steroids are excreted in urine as conjugates of sulfuric acid was made more than 50 yr ago (1, 2). The enzymes responsible for forming the steroid sulfoconjugates, however, were not initially examined until almost 20 yr later (3–6). After that, interest rose rapidly, resulting in considerable progress for this important and intriguing metabolic process. The importance pertains to the striking change in the physical, chemical, and biological properties that occurs on formation of steroid sulfoconjugates; the fascination relates to the fact that the biological significance of this process, for the most part, remains a conundrum. It is especially enigmatic in steroidogenic tissues such as the adrenal, ovary, and testis. The fact is, 40 yr of investigation, notwithstanding, neither the biochemistry nor the biological import of steroid sulfonation is well understood. The enzymology, although appearing simple in principle, is complex and although interesting functional implications have been put forth, the biology of steroid sulfonation has been difficult to assess and thus remains largely speculative.
PTH-073 Cytokine and microrna expression in colonic and ileal crohns disease is modified by drug therapy in an<i>ex vivo</i>model
Authors: SR Whiteoak, T Sanchez-Elsner, JF Cummings
Journal: Gut (2015)

<h3>Introduction</h3> MicroRNAs (miRNA) are short 19–23 nucleotide long strands of RNA which modify post transcriptional gene expression by inhibiting mRNA translation. Studies show there is dysregulation of miRNA expression in IBD but do not take account of factors such as disease activity and drug treatment. The specific function of miRNAs in Crohns Disease (CD) or how they might be utilised is yet to be investigated. We aim to show that mucosal miRNA and mRNA expression in CD is influenced by drugs and has varying effects on the expression in ileum and sigmoid. We use an <i>ex vivo</i>model with active drug to replicate these changes. <h3>Method</h3> Sigmoid or ileal biopsies from 68 patients with either untreated active CD, inactive CD, or monotherapy with Azathioprine, Infliximab or Adalimumab, as well as normal controls, were snap frozen. RT-qPCR assessed expression of miR31, 155 and 146a and genes CCL18 and SOCS1. <i>Ex vivo</i>model: 6 biopsies were taken from the sigmoid colon of 8 patients with active sigmoid CD, and ileum of 7 patients with active ileal CD with a CDAI of 150 or greater. Biopsies were placed in culture media in separate wells with either no treatment, 5-ASA, 6-TG, Infliximab, or Adalimumab, then incubated at 37<sup>o</sup>C. RT-qPCR analysed expression of miRNA and mRNA. <h3>Results</h3> miR31 and CCL18 expression was raised in active sigmoid CD compared to normal mucosa. miR31 expression was not raised in inactive sigmoid disease compared to normal mucosa, however CCL18 expression was. Only Azathioprine decreased miR31 expression. All treatments reduced CCL18 expression, but Azathioprine reduced it lower than untreated inactive disease. Ileal CD showed no increase of miR31 in active disease. CCL18 is reduced in ileal mucosa of CD compared to normal tissue. Only Adalimumab altered CCL18 expression in ileal CD. The <i>ex vivo</i>model showed all the treatments reduced CCL18 expression in active sigmoid CD. miR31 expression was reduced by 6-TG and Infliximab but not Adalimumab. In ileal CD drugs do not change miR31 or CCL18 expression, except for Adalimumab which increased CCL18 expression. <h3>Conclusion</h3> CCL18 and miR31 expression is only increased in sigmoid CD, suggesting different immunological pathways in ileal and colonic CD. Thiopurines are more effective at altering expression in colonic disease. Differential effects of anti-TNFs are of significant interest but require further investigation before any clinical significance can be made. Our data sheds new light on mechanisms of action of current therapy and highlights the importance of controlling for medication when analysing miRNA expression. For the first time we show expression profiles can be manipulated in an <i>ex vivo</i>model. This model could be useful in predicting individual treatment response. <h3>Disclosure of interest</h3> None Declared.
PROPOSED TESTS FOR FATIGUE
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical education
Authors: M. Mann
Journal: JAMA (1979)

With<i>Bakke</i>behind us, other major trends in medical education are on the agenda for critical appraisal. An inventory of the factors that influence teaching programs naturally includes diagnostic innovations, new drugs, budget constraints, alumni pressures, and community needs, as well as scores of other factors. Three developments that have begun to exert influence in the past few years are the Federation Licensing Examination (FLEX), the teaching of medical ethics, and federal rules concerning handicapped faculty and students. The first and second are positive and healthy programs that can only benefit our patients in years to come, but the third, which is forcing the admission or employment of handicapped persons, may be an unwise intrusion into academic policymaking by the federal government. <h3>Licensure Examinations</h3> A decade ago a license to practice medicine was obtained by passing a state board examination or, in some states, an examination administered by the National
Constipation and incontinence
Authors: S Ana, H Raimundo
Journal: Gut (1992)

Fibre supplemented polymeric enteral diets are currently being prescribed widely in the UK.There is also evidence that mineral absorption may be adversely affected by the addition of fibre to the normal diet.As a result, the present study was carried out to quantitate and compare small intestinal absorption of the minerals Ca, Zn, Mg, Fe, Cu, and P during continuous intragastric infusion of:-1) polymeric enteral diet (PD) (6.3gN/l; lKcal/ml), or 2) polymeric enteral diet
Hypertensive Pulmonary Arteritis
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SCORAD III: Randomized noninferiority phase III trial of single-dose radiotherapy (RT) compared to multifraction RT in patients (pts) with metastatic spinal canal compression (SCC).
Authors: Peter Hoskin, Vivek Misra, Kirsten Hopkins, Tanya Holt, Gillian Brown, Seonaid Arnott, Sharon Shibu Thomas, Krystyna Reczko, Sandy Beare, Andre Lopes, Sharon Forsyth
Journal: Journal of Clinical Oncology (2017)

LBA10004 The full, final text of this abstract will be available at abstracts.asco.org at 2:00 PM (EDT) on Friday, June 2, 2017, and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.
Improvement of the computer-assisted differential diagnosis for wide QRS premature complexes Takao Katoh, Tadaaki Ohno, Kenji Yodogawa, Hirokazu Hayakawa, Masaki Kanazawa, Shigeru Shimizu. NipponMedical School, Tokyo, Japan, NEC Co. Ltd., Tokyo, Japan
Journal: Journal of the American College of Cardiology (2001)
The Cover
Authors: Kate Whetzle
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EPHEDRINE AND HABIT FORMATION
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pyelography: Its History, Technique, Uses and Dangers.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cigarette smoking and dysplasia and carcinoma in situ of the uterine cervix
Authors: E. Trevathan
Journal: JAMA (1983)

We conducted a case-control study of cigarette smoking and dysplasia and carcinoma in situ of the uterine cervix. Cases were black women 17 to 55 years of age who were attending a dysplasia clinic and had biopsyconfirmed cervical pathologic conditions. Controls were women who were attending the family planning clinic at the same hospital and who had at least two normal Papanicolaou smears. Results were adjusted for age, number of sexual partners, age at first intercourse, socioeconomic status, and oral contraceptive use. Cigarette smoking was significantly associated with carcinoma in situ, severe dysplasia, and mild-moderate dysplasia (relative risks, 3.6, 3.3, and 2.4, respectively). Cumulative exposure to cigarette smoking (as measured by pack-years smoked) was strongly related to the risk of these conditions; women with 12 or more pack-years of exposure had relative risks of 12.7, 10.2, and 4.3, respectively, for the three conditions. There was some evidence that the risk was greatest in women who began smoking in their early teenage years. A reduction in the risk of cervical cancer appears to be another inducement for young women not to smoke. (<i>JAMA</i>1983;250:499-502)
BLOOD AND BLOOD BANKING
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glycoengineered CD20 Antibody Obinutuzumab Activates Neutrophils and Mediates Phagocytosis Through CD16B More Efficiently Than Rituximab
Authors: Josée Golay, Fabio Da Roit, Luca Bologna, Claudia Ferrara Koller, Jeanette H. W. Leusen, Alessandro Rambaldi, Christian Klein, Martino Introna
Journal: Blood (2013)
Long-term decrease in serum N-terminal propeptide of type III procollagen in patients with chronic hepatitis C treated with interferon alfa
Authors: T SUOU
Journal: Hepatology (1995)

To evaluate the effect of interferon alfa (IFN-α) on the hepatic extracellular matrix, we investigated the changes in serum N-terminal propeptide of type III procollagen during and after 4 months of INF-α treatment in 178 treated and 45 nontreated patients with chronic hepatitis C. Serum pretreatment levels in nonresponders were significantly higher than those in long-term and short-term responders, but those levels were not different in the latter two groups. Serum propeptide levels decreased significantly during and after IFN-α therapy in the treated patients, although those levels were unchanged in the nontreated patients. This decrease was sustained for 12 months after IFN-α was completed not only in long- but also in short-term responders and nonresponders. Serum propeptide levels decreased in those with elevated pretreatment levels, but not in those with normal initial levels, whereas serum transaminase levels decreased similarly in both groups. The changes in serum propeptide levels during and after treatment were more closely correlated with the initial levels compared with those in serum transaminase levels. These results suggested that IFN-α treatment induces the long-term suppression of active fibrogenesis in chronic hepatitis C independent of antiviral and anti-necroinflammatory effects, thus preventing progression to cirrhosis. (Hepatology 1995; 22:426–431.)
Views of reason for mad cow disease vary widely
Authors: C. Marwick
Journal: JAMA (1996)

EXCITEMENT caused by the epidemic of bovine spongiform encephalopathy (BSE) among British cattle, popularly known as "mad cow disease," has also stimulated renewed interest in a rare human neurodegenerative disorder, Creutzfeldt-Jakob disease (CJD). The disorders are related, but whether the 10 cases of CJD recently reported in Great Britain were the result of eating meat from cows infected with the BSE agent remains speculation. "But," said a British authority, "it would be prudent to remain open-minded about dietary exposure" (<i>Lancet</i>. 1996;347:916,945-948). As always with mysterious disorders and unsolved riddles, public interest is high. <h3>Two Capital Conferences</h3> This interest brought 2 experts on CJD to separate forums this spring in Washington, DC. Stanley Prusiner, MD, professor of neurology at the University of California, San Francisco, School of Medicine, addressed a meeting on Capitol Hill of the Congressional Biomedical Research Caucus, a group that regularly briefs congressional staff on health issues. Prusiner
Ang-2 polymorphisms in relation to outcome in advanced HCC patients receiving sorafenib
Authors: Giorgia Marisi, Alessandro Passardi, Mario Scartozzi, Nicola Silvestris, Martina Valgiusti, Paola Ulivi, Luca Faloppi, Oronzo Brunetti, Luca Frassineti Giovanni, Andrea Casadei Gardini
Journal: Annals of Oncology (2017)
Foetal psoriasis
Authors: L. Stankler
Journal: British Journal of Dermatology (1988)

Journal Article Foetal psoriasis Get access L. Stankler L. Stankler Department of Dermatology, ABERDEEN ROYAL INFIRMARY, ABERDEEN AB9 2ZB, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 119, Issue 5, 1 November 1988, Page 684, https://doi.org/10.1111/j.1365-2133.1988.tb03484.x Published: 01 November 1988
CATHETER BROKEN OFF IN PROSTATIC PORTION OF URETHRA—EXPEDITIOUS REMOVAL.
Authors: ARTHUR L. WORDEN
Journal: JAMA (1883)

I notice, in your issue for Sept. 15, the paper of Dr. Hard, in which he recommends a sharp, screwpointed instrument for removing broken catheters from the urethra. This cut represents an instrument which once helped me out of such a difficulty without the patient even knowing what had happened. I had occasion to pass a soft rubber catheter, No. II, into the bladder of a colored man. After drawing his urine and attempting to withdraw the catheter, imagine my dismay at having it break off in the prostatic region. Without mentioning the fact, I immediately passed the urethral forceps, and easily securing a grasp upon the broken end, at once withdrew the fragment entire. On another occasion, I was unfortunate enough to have a pledget of absorbent cotton slip off my applicator and remain in the cavity of the uterus. Again my alligator urethral forceps