tbuckley/cabot-search huggingface dataset:
Functional Genomics in Zebrafish Permits Rapid Characterization of Novel Platelet Membrane Proteins
Authors: Isabelle I Salles, Marie N O’Connor, Nicholas A. Watkins, Adam Walker, Stephen F Garner, Chris I Jones, Iain Macauley, Michael Steward, Jaap Jan Zwaginga, Sarah L Bray, Ana Cvejic, Frank Dudbridge, Bernard de Bono, Hans Deckmyn, Derek L. Stemple, Willem Ouwehand
Journal: Blood (2008)
Improved detection of early iron deficiency in nonanemic subjects
Authors: S. McClure
Journal: JAMA (1985)

We measured the complete blood cell count, including the index of RBC size heterogeneity (RBC distribution width [RDW]), in 181 subjects without anemia to determine whether RDW became abnormal earlier in the development of iron deficiency than did other variables. In 163 subjects selected only for otherwise normal blood cell counts, an increased RDW was 66% specific (48/73) and 100% sensitive (48/48) for decreased serum iron saturation. Stool guaiac testing was equally specific but less sensitive. In 13 subjects with polycythemia, as iron deficiency developed, RDW increased a minimum of four weeks before mean cell volume changed. In one apparently normal young woman, an abrupt isolated rise in RDW revealed a newly developed low serum transferrin saturation; all values remained normal during serial testing of four other normal subjects. We conclude that RDW is the part of the routine blood cell count that first becomes abnormal during the development of iron deficiency. (<i>JAMA</i>1985;253:1021-1023)
Strümpell-Seyfarth Lehrbuch der speziellen Pathologie und Therapie der inneren Krankheiten für Studierende und Ärzte.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allogeneic bone marrow transplantation for a patient complicated by chronic hepatitis due to precore mutant hepatitis B virus: Failure of management with interferon‐α therapy
Authors: Yuji Miura, Hideyuki Takamatsu, Hirokazu Okumura, Takashi Yoshida, Shinji Nakao, Tamotsu Matsuda
Journal: American Journal of Hematology (1997)
Human cholecystitis is associated with increased gallbladder prostaglandin I2 and prostaglandin E2 synthesis
Authors: S Myers
Journal: Hepatology (1992)

Microsomal prostanoid synthesis was compared in normal gallbladders removed during organ donation and inflamed gallbladders removed at cholecystectomy. Normal human gallbladder microsomes demonstrated low rates of conversion of [14C]arachidonic acid to total labeled prostanoids, which increased during 1 to 30 min of incubation. Normal human gallbladder microsomes converted labeled substrate to all primary prostaglandins without demonstration of a major product. Inflamed human gallbladder microsomes increased the rate of conversion of [14C]arachidonic acid to total labeled prostanoids two or three times over the levels demonstrated by normal gallbladder microsomes at all times of incubation (p < 0.01). The main prostanoids synthesized by the inflamed human gallbladder microsomes were prostaglandin E2 and 6-keto-prostaglandin F1α, which were increased four times over the levels demonstrated by normal gallbladder microsomes (p < 0.01). These data showed that inflammation of the human gallbladder was associated with increased synthesis of gallbladder 6-keto-prostaglandin F1α, and prostaglandin E2. (HEPATOLOGY 1992;16:1176–1179.)
Reducing blood cholesterol levels in children. What have we learned from the DISC study?
Authors: R. V. Luepker
Journal: JAMA (1995)

The main findings of the multicenter Dietary Intervention Study in Children (DISC) are presented in this issue ofThe Journal.<sup>1</sup>This national project sought to evaluate the safety and efficacy of lowering dietary total fat, saturated fat, and cholesterol in reducing low-density lipoprotein cholesterol (LDL-C) in healthy hypercholesterolemic children. The results have important implications for clinicians who provide care for children, public health officials, and future research in cardiovascular disease prevention. DISC represents an intense effort to modify food intake in healthy free-living children by dietary education of students and their parents. The intervention was well designed and used current behavioral modification techniques to change eating patterns. The results of DISC deserve serious consideration given the study size and quality of the design. The first finding relates to the safety of a low-fat diet, which some have suggested is deleterious to the growth and development of children.<sup>2</sup>DISC
Racial/Ethnic Disparities in Neonatal Mortality—United States, 1989-2001
Journal: JAMA (2004)

peated unprotected exposures, especially in the presence of syphilitic lesions, represent a substantial risk for HIV transmission.Syphilis might also increase progression of HIV disease. 6,7 The findings in this report are subject to at least one limitation.The data might underestimate the role of oral sex in syphilis transmission because most persons who reported engaging in anal and vaginal sex also reported engaging in oral sex.Transmission was attributed to oral sex in only the 14% of cases in which oral sex was the only sexual exposure reported during the interval when syphilis likely was acquired.Some men who engaged in only oral sex believed that they were practicing safe sex and were surprised when they received a syphilis diagnosis.These data underscore the need for educating sexually active persons regarding the risk for syphilis transmission through oral sex.That syphilis might hasten the progression of HIV disease should provide a further motivation for MSM, especially HIV-infected MSM, to avoid syphilis acquisition.Persons who are not in a long-term monogamous relationship and who engage in oral sex should use barrier protection (e.g., male condoms or other barrier methods) to reduce the risk for STD and HIV transmission.
Asthma
Authors: Mary Lee Vance
Journal: New England Journal of Medicine (2009)

A necessary limitation of a book on any medical topic is the delay between submission and publication.This delay makes it impossible for authors to include information on the most recent scientific studies -information that is particularly important for chapters that involve newly published outcomes of treatments.An example of this difficulty is found in chapter 17, "Radiation Therapy for Pituitary Adenomas."Its authors provide an excellent summary of indications for treatment, methods of radiation delivery, outcomes, and complications, but the referenced studies are inclusive only up to 2007.The three-part chapter on acromegaly is concise and informative.Its one shortcoming is the result of what has been a widespread problem in the United States for more than a year -the range of normal values according to age for the insulinlike growth factor I assays that are commercially available is too low.This inaccuracy can lead to misdiagnosis of acromegaly or relapse of treated acromegaly.The chapter on the diagnostic evaluation of Cushing's disease addresses the most problematic area of pituitary disorders.The authors have been at the forefront of establishing that late-night levels of cortisol in saliva are an indicator of loss of the normal circadian rhythm of cortisol production.The presence of high levels of cortisol in saliva may be detectable before the 24-hour urinaryfree cortisol concentration is abnormally elevated.A shortcoming of this discussion is that the authors fail to mention the variability or reliability in results from various commercial laboratories.Essentially, the diagnosis of Cushing's disease on the basis of the measurement of salivary and urinary-free cortisol levels remains problematic.The discussions of the results of pituitary surgery are informative and well written by neurosurgeons who have experience in the field.What is not adequately discussed, however, is the need for a neurosurgeon who has adequate experience and expertise with this operation.The results of pituitary surgery are reported only by neurosurgeons who devote their practices to this procedure; outcomes from neurosurgeons who perform the operation infrequently are not reported.Overall, this book is useful for the general medical community and for clinical endocrinologists.Its major strengths are the comprehensiveness of the chapters and the quality of the details and writing.This is a valuable addition to any medical library.
Combination of Colonoscopy and Clip Application with Angiography to Mark Vascular Malformation in the Small Intestine
Authors: S Gölder, M Strotzer, S Grüne, C Zülke, J Schölmerich, H Messmann
Journal: Endoscopy (2003)

Figure 1 A 55-year-old woman was admitted with chronic recurrent lower gastrointestinal bleeding. Previous examinations, including esophagogastroduodenoscopy and colonoscopy, during an active bleeding episode, revealed no bleeding site. Angiography showed a vascular malformation in projection to the right sided colon or neoterminal ileum (arrow).
"EDDYISM."
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control and Prevention. Population-based mortality assessment: Baidoa and Afgoi, Somalia, 1992
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians' responsibility in prevention of bodily injuries by the automobile
Authors: S. Charles
Journal: JAMA (1966)

The automobile is the etiological agent in an epidemic accounting for some 50,000 deaths and 4 million injuries each year. This epidemic is outranked as the cause of death in our country today only by cancer and cardiovascular disease.<sup>1-3</sup>The automobile is the first cause of death in young people between the ages of 15 and 24 years, therefore the principal killer of our young parents. The probabilities are that one out of every two Americans will be involved in his lifetime in an injury-producing collision. There are now some 95 million drivers in this country. By 1975 there are expected to be an additional 30 million drivers. At the current rate of increase (17% in the last two years) in the next decade, the annual death rate from the automobile will pass the 100,000 mark and the cost of accidents will climb from 8.2 to 15 billion per
Some Observations Upon Selective Vagotomy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's new in the other general journals
Authors: Alison Tonks
Journal: BMJ (2006)

Vitamins do not stop pre-eclampsiaAcademics from the United States have urged researchers to get back to basics in their search for a preventive treatment for pre-eclampsia, arguing in an editorial that limited research funds should be diverted away from expensive clinical trials until we know more about just what causes pre-eclampsia and how.Large trials of various treatments have so far failed to deliver-including trials of aspirin, calcium supplements, and the antioxidant vitamins C and E.In the latest trial, antioxidant vitamins did not prevent pre-eclampsia in women at high risk and may even have made it worse.Pre-eclampsia happened earlier in women who took the vitamins, and their babies weighed less at birth than women who took a placebo.Worse, the supplements were associated with significantly more unexplained fetal deaths after 24 weeks (19/1393 (1%) v 7/1391 (0.5%); risk ratio 2.7, 95% CI 1.0 to 7.1).Without a better understanding of the complex pathophysiology of pre-eclampsia, trials of preventive treatments are little more than a stab in the dark, says the editorial, even if they are driven by plausible theories and hopeful hints from small preliminary studies.But trials of antioxidant vitamins are already well underway.Their investigators have been warned.
Criteria for the Evaluation of the Severity of Established Renal Disease
Authors: COUNCIL ON THE KIDNEY IN CARDIOVASCULAR DISEASE, AMERICAN HEART ASSOCIATION, 1971
Journal: Annals of Internal Medicine (1971)

Diagnosis and Treatment1 August 1971Criteria for the Evaluation of the Severity of Established Renal DiseaseCOUNCIL ON THE KIDNEY IN CARDIOVASCULAR DISEASE, AMERICAN HEART ASSOCIATION, 1971COUNCIL ON THE KIDNEY IN CARDIOVASCULAR DISEASESearch for more papers by this author, AMERICAN HEART ASSOCIATION, 1971Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-2-251 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUse of the CriteriaPatients should be placed in one class from each of three major categories: severity of signs and symptoms; severity of renal functional impairment; and level of performance. In each major category the user should select the highest class whose criteria are fulfilled.For example, a patient would be graded as II-C-1 if signs and symptoms fit class II under severity of signs and symptoms, if the creatinine clearance is 30% of predicted normal, and if all usual types of physical activity can be carried out. If the patient is unable to carry out his or her... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrognosis of idiopathic membranous nephropathy: A methodologic meta-analysisAge-Adjusted Standards for Creatinine ClearanceJOHN W. ROWE, M.D., REUBIN ANDRES, M.D., JORDAN D. TOBIN, M.D., ARTHUR H. NORRIS, M.S., NATHAN W. SHOCK, PH.D.Severity of Established Renal Disease: Criteria for EvaluationWILLIAM B. BLYTHE, M.D. 1 August 1971Volume 75, Issue 2Page: 251-252KeywordsCreatinineExerciseRenal diseasesSigns and symptoms ePublished: 1 December 2008 Issue Published: 1 August 1971 PDF downloadLoading ...
Manuscripts Approved for JNCI, August 15 to September 15, 1961
Journal: JNCI Journal of the National Cancer Institute (1961)

Manuscripts Approved for JNCI, August 15 to September 15, 1961 Get access JNCI: Journal of the National Cancer Institute, Volume 27, Issue 4, October 1961, Pages 935–936, https://doi.org/10.1093/jnci/27.4.935-a Published: 01 October 1961
Notices
Authors: Mrs Bernie, C Kern
Journal: Hepatology (1992)

This conference, titled "Regulation of Hepatic Cholesterol Transport and Metabolism," will be held in Aspen at the Given Institute of the University of Colorado School of Medicine.The conference will be chaired jointly by Donald M. Small (Boston University) and Fred Kern, Jr. (University of Colorado).It will focus on mechanisms of regulation of the transport of cholesterol into the liver from the plasma and out of the liver in lipoproteins and biliary acids and as biliary cholesterol.Topics and speakers: 7a-hydroxylase (J.Chaing, R. Davis and R. Vlahcevic); 26-hydroxylase (N
Family History Information Enables Physicians to Recognize Genetically 'At-Risk' Patients
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The liver and erythropoietic protoporphyria.
Authors: T Cadell, R Stevenson
Journal: BMJ (1971)

of diagnosed infections, let alone those that have not been detected.More serious is the fatality rate in people with P. falciparum malaria.Since 1954 at least 60 people have died in Britain owing to the belated diagnosis and difficult treatment of severe cases of falciparum malaria.The patient may deteriorate fast within a few hours of the first symptoms.In the Netherlands,'6 out of 140 patients with falci- parum malaria seen between 1956 and 1967 10 died of cerebral infection.Information from other European countries, and especi- ally from Germany" and France,'7 confirms the disturbing lack of awareness among medical practitioners and among the general public of the frequency of imported tronical disease, the best means of its easy prevention, and of the need for its early detection and treatment.Much credit for stimulating a higher level of vigilance among the medical profession must go to the Royal College of Physicians of London,'8 while the Ross Institute continues to inform and advise the public at large through its useful publication.'9
Incorrect Affiliation
Journal: JAMA Surgery (2013)

Robert M. Rodriguez, MD; Deirdre Anglin, MD, MPH; Mark I. Langdorf, MD; Brigitte M. Baumann, MD, MSCE; Gregory W. Hendey, MD; Richard N. Bradley, MD; Anthony J. Medak, MD; Ali S. Raja, MD, MPH; Paul Juhn, MD; Jonathan Fortman; William Mulkerin; William R. Mower, MD, PhD
BOOK REVIEWS
Authors: C. S. PORTLOCK
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Hodgkin's Disease: The Consequences of Survival . Mortimer J. Lacher , John R. Redman , eds. Philadelphia : Lea & Febiger , 1990 , xvi, 447 pp. $80. CAROL S. PORTLOCK, M.D. CAROL S. PORTLOCK, M.D. Memorial Sloan-Kettering Cancer Center1275 York Ave. New York, NY 10021 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 15, 7 August 1991, Pages 1106–1107, https://doi.org/10.1093/jnci/83.15.1106 Published: 07 August 1991