tbuckley/cabot-search huggingface dataset:
Anatomy of the Soul
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive biomarkers in circulating tumor cells (CTC) from patients with castration-resistant prostate cancer (CRPC) through genomic analysis.
Authors: Daniel Costin Danila, Aseem Anand, Jianchao Yao, Magdalena Gierszewska, Melissa Kramer, Stephanie Muller, Martin Fleisher, William R. McCombie, Howard I. Scher
Journal: Journal of Clinical Oncology (2012)

179 Background: Although designed to retain activity against known androgen receptor (AR) mutants, it is predicted that new MDV3100-resistant mutations may predict for sensitivity to the drug in clinic. To predict for tumor sensitivity to treatment with novel AR targeted therapies, we explored the frequency of mutation detection and copy number alteration in CTC isolated from patients with CRPC enrolled on a trial with MDV3100. Methods: We used fluorescence-activated cell sorting (FACS) methodology to enrich EpCAM + , CD45 − , DAPI − cells. For mutation detection and genomic copy number alteration in CTC in low number of cancer cells found in clinical samples, we optimized next-gen deep sequencing by Illumina. Results: In patients with progressive CRPC, &gt;10 or &gt;50 EpCAM + events (EPE) were isolated by FACS in 88% or 58% of patients, in whom 32% and 10% had unfavorable (&gt;5 cells/7.5 ml) CTC counts using CellSearch. EPE, expressing prostate-specific mRNAs, provide sufficient high quality DNA for genomic sequencing and copy number analysis. Adequate coverage was obtained from as few 50 EPE, with a recovery rate of 89% from FACS sorted samples. The detection threshold of a mutation was established at 1:4 alleles. To further expand genomic profiling in CTC, we optimized Nimblegen exome mutation detection by deep sequencing on HiSeq PE101. Our initial analysis established the polymorphism frequency detection thresholds in heterogeneous cell populations, and confirmed the sequencing coverage. Somatic missense mutations in AR, APC and TP53 found in CTC but not in paired WBC were confirmed by Sanger sequencing. In parallel, copy number alterations in CTC are studied. Conclusions: Somatic mutations detected in CTC isolated from patients with CRPC can serve as predictive markers of tumor sensitivity to targeted therapies. We established standard operating procedures for specimen processing, and confirmed the sequencing coverage and polymorphism detection thresholds in heterogeneous cell population. Currently we are proceeding to clinical samples to study the associations between specific molecular alterations in CTC as predictive markers of sensitivity and clinical outcomes.
Gonadal late effects, fertility and sexual functioning in long-term survivors after high-dose chemotherapy with autologous stem cell transplantation (HD-CT) for testicular cancer
Authors: C. Kollmannsberger, N. Schleucher, O. Rick, B. Metzner, K. Schaefer-Eckart, R. Naumann, R. Mayer-Steinacker, J. T. Hartmann, L. Kanz, C. Bokemeyer
Journal: Journal of Clinical Oncology (2004)

4537 Background: Dose-intensive chemotherapy is currently used in patients (pts) with "poor prognosis" or relapsed germ cell cancer. No studies have thus far investigated endocrinological disturbances, infertility, parenthood, and subjective patient impairment with respect to sexual functioning in long-term survivors after HD-CT. Patients and methods: 53 pts treated within prospective trials of the German Testicular Cancer Study Group and a minimum follow-up of 6 months after completion of HD-CT agreed to complete a standardized and validated questionnaire regarding the subjective impact of HD-CT on fertility and sexual functioning. Testosteron, FSH, and LH levels were investigated in 33 of these pts. All pts were recruited during routine follow-up visits in 2002–2003. Results: Median age at initial diagnosis was 31 years [17–60]. 55% of pts were followed for 1–2 years after therapy and 45% for 2.1–8 years after therapy. 30% of pts had received HD-CT as second-line and 70% as first-line therapy. Testosterone levels were normal in 32/33 pts (97%) with a median of 4.7 ng/ml [range: 1.15–9.97 ng/ml]. LH and FSH levels were elevated in 45% and 91% of pts, respectively. Median levels of LH and FSH were 8.9 U/l [range: 2.8–25 U/l] and 21.4 U/l [range: 0.3–54 U/l], respectively. 4 healthy children had naturally been conceived by 2 men with all of them being healthy. 70% of pts stated to have had a "very satisfactory sex life" prior to therapy, but only 48% were "very satisfied" after therapy (p=0.05). 27% of pts had a "poor sex life" after therapy in contrast to none prior to therapy (p=0.05). 57% of pts had reported "frequent sexual intercourse" prior to therapy but only 42% after treatment (p=0.05). The frequency of "lack of libido" raised from 11% prior to 34% after therapy (p=0.05). Conclusions: Pts receiving HD-CT for testicular cancer should be advised about possible effects on sexual functioning and counselling should be offered after therapy. Sperm banking should be recommended to all pts undergoing HD-CT, despite the fact that single pts may still retain full fertility. No significant financial relationships to disclose.
Awards for Community Service
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician experience and challenges obtaining unfunded oral chemotherapy across Canada.
Authors: D. Han, S. Hogeveen, M. Trinkaus, M. Mamdani, S. R. Berry, R. W. Jang, J. Hoch, C. E. Simmons
Journal: Journal of Clinical Oncology (2011)

e16583 Background: Previous studies have shown hematologists and medical oncologists may not accept the financial limits set by governing agencies on access to oral chemotherapy for their patients. This requires increased time and effort on the clinician’s part to obtain funding. We captured physicians’ perceptions of barriers to obtaining unfunded chemotherapies and methods used to overcome these barriers. Methods: A total of 640 medical oncologists and hematologists were surveyed using a web-based survey tool. A thirteen-item survey was designed to assess the practice type along with time spent and methods used on obtaining unfunded oral chemotherapy. Results: Of the 640 invitees, 568 were delivered and 168 responded,(response rate 30%). 91 respondents were medical oncologists, 44 were hematologists and 33 treated both solid and non-solid malignancies. 65% of physicians spent an average of 1-4 hours obtaining funding for oral drugs for patients per week. 62% indicated their institution has a drug access coordinator (DAC). Having a DAC did not impact the proportion of physicians spending >4 hrs/ week accessing oral drugs (38% vs 29%, p=NS). To overcome barriers to funding, physicians’ enrolled patients on clinical trials (91%), used compassionate access programs (96%) or special request forms to government (92%). Other methods included writing false claims on forms to fit funding criteria for a drug (36%) or use of leftover drug supplies (36%). The majority of physicians felt that their inability to obtain unfunded medications for their patients has negatively impacted patients’ clinical outcomes (56%) and psychosocial quality of life (74%). Of all respondents, only 28% of physicians contacted their governing body with concerns of funding for oral chemotherapy. Conclusions: Practicing hematologists and medical oncologists in Canada use numerous methods to obtain unfunded oral chemotherapies, including lying on access forms. Overall, the majority of physicians spend 1-4 hours a week on obtaining funding; this did not differ for physicians with or without a DAC at their practice. Despite the challenges in accessing oral chemotherapies, most physicians have not contacted governing bodies for legislative change.
Homing Pigeons as Medical Messengers.
Authors: Philip Arnold
Journal: JAMA (1898)

Elizabeth, Ill., March 31, 1898. <h3>To the Editor:</h3> —For several years the undersigned has had' under consideration homing pigeons as medical messengers. My correspondence with doctors who use them for this purpose, and also information obtained in medical journals and books bearing on the subject, so encouraged me that I was induced to invest in some of the "Belgian Homer" pigeons, and now have established a loft of aerial messengers as part of my equipment as a medical practitioner. The young birds now under training encourage me to say to theJournalreaders that my expectations have not been dimmed, and I am convinced that if medical men will look into this matter, if they have not already done so, they too will find it feasible. In order to have the homer pigeon serve me in an efficient manner, I am having the entrance to the loft connected with electric
Behavioural counselling in primary care leads to improvements in health behaviour
Journal: BMJ (1999)

Behavioural counselling in primary care leads to improvements in health behaviour Behavioural counselling in primary care leads to greater improvements in health behaviour than standard health education and advice in patients at increased risk of coronary heart disease.Previous studies of health promotion and lifestyle counselling in primary care have produced disappointing results.Steptoe et al (p 943) found in a randomised trial that brief behavioural counselling on the basis of the "stage of change" model stimulated greater reductions in dietary fat intake and number of cigarettes smoked, and greater increases in physical activity than did usual care.The results suggest that behavioural counselling in primary care may be a useful strategy in the prevention of coronary heart disease.
Abstract 1564: Polymorphisms in nucleotide excision repair genes were associated with the survival of post-operative oral squamous cell carcinoma patients treated with adjuvant concurrent chemoradiotherapy
Authors: Chih-Ching Yeh, Thomas Senghore, Huei-Tzu Chien, Wen-Chang Wang, You-Xin Chen, Chi-Kuan Young, Shiang-Fu Huang
Journal: Cancer Research (2019)

Abstract Background: The nucleotide excision repair (NER) pathway plays a major role in the repair of DNA damaged by exogenous agents including chemo-and radiotherapeutic agents. Thus, we investigate the association between key potentially functional single nucleotide polymorphisms (SNPs) in the NER pathway and clinical outcomes in oral squamous cell carcinoma (OSCC) patients treated with concurrent chemoradiotherapy (CCRT). Methods: Thirteen SNPs in five key NER genes were genotypes in 319 OSCC patients using iPLEX MassARRAY. Multivariate Cox proportional hazards models and Kaplan-Meier survival curves were used to estimate risk of death or recurrence. Results: Carriers of the XPC rs2228000 TT genotype showed a borderline significant increased risk for poor overall survival under the recessive model (hazard ratio [HR]=1.81, 95% confidence interval [CI]=0.99–3.29). The CC genotypes of ERCC5 rs17655 (HR=1.54, 95% CI=1.03–2.29) and ERCC1 rs735482 (HR=1.65, 95% CI=1.06–2.58) were associated with an increased risk for worse disease-free survival under the recessive model. In addition, participants carrying both CC genotype of ERCC5 rs17655 and ERCC1 rs735482 exhibited an enhanced susceptibility for recurrence (HR=2.60, 95% CI=1.11–6.09). However, no statistically significant interaction was observed between them. Conclusion: Our findings show that the ERCC5 rs17655 CC and ERCC1 rs735482 CC genotypes were associated with an increased risk for recurrence in OSCC patients treated with CCRT. Therefore, CCRT may not be beneficial and alternative treatments are required for them. Citation Format: Chih-Ching Yeh, Thomas Senghore, Huei-Tzu Chien, Wen-Chang Wang, You-Xin Chen, Chi-Kuan Young, Shiang-Fu Huang. Polymorphisms in nucleotide excision repair genes were associated with the survival of post-operative oral squamous cell carcinoma patients treated with adjuvant concurrent chemoradiotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1564.
Massachusetts Medical Society
Authors: None E.A.
Journal: New England Journal of Medicine (1969)

DONALD DARROW MATSONDonald Matson, a worthy successor to Dr. Harvey Cushing at the Peter Bent Brigham Hospital, died on May 10, 1969, in his fifty-sixth year. He was president of the American Association of Neurological Surgeons, founded in 1931 as the Harvey Cushing Society, now the largest and most influential neurosurgical society in America. Much effort and planning was expended by Dr. Matson to arrange this year's meeting, the centennial of Dr. Cushing's birth. All those close to Donald Matson suffered a severe disappointment when his illness, ultimately fatal, prevented his participation in that meeting.Bemoaning the last tragic . . .
Münchener Medizinische Wochenschrift
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tellymedicine
Authors: Jurgen A H R Claassen
Journal: BMJ (2005)

a similarly systematic and long lasting way as are patients with high grade lesions.Inadequate follow-up is a major factor, as suggested in the literature. 6-9 Treatment of cervical intraepithelial neoplasia is, however, effective.In an earlier study of CIN 3 lesions, 10 it was estimated that 28-39% of cases without treatment would progress to invasive cancer.Our data contained 837 cases of CIN 3 lesions in women aged 30-59, thus on the basis of the previous estimate, 234-326 would develop into invasive cervical cancers, not the three observed.The treatment effect might have been nearly 100%.
Multiple use of disposable insulin syringe-needle units
Authors: R. H. Hodge
Journal: JAMA (1980)

Fourteen insulin-dependent diabetics were asked to use their insulin syringe-needle units three times in succession to determine the efficacy and safety of this practice. The mean duration of time each patient participated in the study was 20.4 weeks, and a total of 2,000 injections were taken. No signs of infections at the injection site were observed. Multiple use of disposable insulin syringe-needle units appears to be safe and cost-beneficial. (<i>JAMA</i>244:266-267, 1980)
The histopathology of rat lung following exposure to zinc oxide/hexachloroethane smoke or installation with zinc chloride followed by treatment with 70% oxygen.
Authors: R F Brown, T C Marrs, P Rice, L C Masek
Journal: Environmental Health Perspectives (1990)

The effects of inhaled zinc oxide/hexachloroethane smoke (11,580 mg x min/m3) and intratracheally instilled zinc chloride (2.5 mg/kg body weight) have been studied in rat lung. The effects of subsequent treatment with 70% oxygen have been studied after both procedures. Both the inhalation of the smoke and instillation of zinc chloride produced similar effects that included pulmonary edema, alveolitis and, at a later stage, some fibrosis. After zinc chloride instillation, the pathological changes largely spared the periphery of the lung, while following smoke inhalation they were more diffuse. Subsequent oxygen administration had little effect on the development or progression of the pathological changes.
In Reply:
Authors: Martin Stockler
Journal: Journal of Clinical Oncology (2005)

IN REPLY: Period analysis resulted in estimates of 40year absolute and relative (absolute/population) survival curves.The Methods section of the article by Brenner and Hakulinen 1 states that the estimates are intended to reflect cumulative survival experience for newly diagnosed patients.It is not clear how this differs from "current estimates of long-term survival expectations."Patients diagnosed 40 years ago did remain at increased risk of death through the 1990s, as demonstrated by relative conditional probabilities by decade.This point does not depend on period analysis, which uses conditional probabilities from the past for projections into the future.To the extent that the past conditional probability estimates will no longer apply, we cannot rely on the accuracy of the projections in the coming decades, empirical observations from previous decades notwithstanding.The implausible assumption of a cure for death would indeed have provided a striking but irrelevant example.I sincerely hope the breast cancer cure scenario is neither implausible nor irrelevant.
The milk sickness. Drake on medical interpretation
Authors: R. E. Niederhofer
Journal: JAMA (1985)

Milk sickness was one of the most obscure diseases to confront the pioneers of the 1800s. Since the disease was unknown in Europe and the New England states, the physicians along the East Coast tended to deny its existence. Yet as more and more pioneers crossed the mountains into the Midwest, the mortality rate increased. In Madison County, southwest of Columbus, nearly one fourth of the early settlers died of this mysterious illness. During the epidemic of 1818 the little community of Pigeon Creek, Ind, was almost exterminated by the pestilence. One casualty was Abraham Lincoln's mother, Nancy Hanks. Few medical journals were available to the pioneer physicians before the middle of the 19th century and there were few means of sharing information, so that facts about milk sickness accumulated very slowly. The illness remained mysterious until the early part of the 20th century.<sup>1,2</sup> Milk sickness is now known
PTU-105 Outcome of Cirrhotic Patients Admitted to Intensive Care Units at Hospitals without Specialist Liver Services
Authors: G Beejooa, R Oates, L Loo, N Mirza, S Shah, C Grimley, G Watts, N Prasad, N Kochar, A Al Rifai
Journal: Gut (2013)

<h3>Introduction</h3> Patients with liver cirrhosis admitted to an ICU are believed to have a poor prognosis with high mortality despite significant use of resources. Most of the literature to date on this topic has been collected at hospitals with Specialist Liver Units and these results may not be representative of the outcome at general ICUs. A recent prospective study of cirrhotic patients admitted to a tertiary Liver ICU in the UK demonstrated an overall hospital mortality of 59%. The aim of this study was to determine the outcome of cirrhotic patients admitted to non-specialist ICUs. <h3>Methods</h3> Data was retrospectively collected from four hospitals in the NW region of the UK without specialist liver ICUs. Patients were identified using the Intensive Care National Audit and Research Unit (ICNARC) database. 61 patients with liver cirrhosis admitted to a general ICU between January 2010 and January 2012 were included in this study. <h3>Results</h3> Age range was 30 to 79 years (average 51 years). 80% of patients were male and alcohol was the commonest aetiology for liver cirrhosis (90%). The main reason for admission to ICU was for gastrointestinal bleeding (38%). 51% of patients had a Child Pugh score of C on admission to ICU. 46% of patients had a MELD score between 10 and 19 and 28% had a score between 20 and 29. 79% of patients required invasive ventilatory support, 49% required vasopressors and 21% needed renal replacement therapy. 51% developed further decompensation of their liver disease during their ICU stay. These included GI bleeding (21%), hepatic encephalopathy (15%), HRS (11%) and SBP (3%). 67% of patients had an ICU stay of &lt; 5 days. A 49% inpatient mortality rate was observed in our study with sepsis and multi-organ failure being the most common causes of death. <h3>Conclusion</h3> Patients with liver cirrhosis admitted to general ICUs have similar rates of mortality compared to those in tertiary liver ICUs. Therefore, admission to such units should not be deemed futile in cirrhotic patients and earlier admission may improve outcome. <h3>Disclosure of Interest</h3> None Declared
Exophthalmos and treatment of Graves' disease
Authors: J. H. Gaskin
Journal: JAMA (1982)

<h3>In Reply.—</h3> The apparent discrepancies noted between the figures are related to the method of data presentation. Each patient within a group had a series of sequential observations. To display all of the individual patients as lines on the graphs would be unwieldly, so the data were averaged at each time point, and the means were displayed. The problem noted comes from the handling of missing observations. In Fig 1, a few missing observations have a strong effect on the mean of some groups, eg, the 18-month point for group 4, where a number of the patients with the highest general values were not observed at that time. The analysis of variance method chosen requires a complete design, and missing values were supplied by interpolation, as mentioned in the "Statistical Methods" section. The means that resulted from this procedure were then displayed in Figs 2 through 4 and represent the