tbuckley/cabot-search huggingface dataset:
The 1995 Albert Lasker Medical Research Award. The concept of antigen processing and presentation
Authors: E. R. Unanue
Journal: JAMA (1995)

THE IMMUNE RESPONSE to protein antigens operates through lymphocytes (the T cells) that recognize products of digestion of the protein antigens. It took years of efforts by many investigators studying different aspects of immunity to reach this conclusion. The initial thinking was that the immune response was directed to antigen not altered by normal catabolism. This holds true for responses of B cells but is definitely not the case for T cells. The CD4 T cells are the essential regulatory cells that influence the function of most leukocytes. Their antigen-specific receptors recognize only protein catabolites that are bound to histocompatibility molecules. <h3>ANTIGEN PRESENTATION BY MACROPHAGES</h3> Through our initial studies on macrophage biology, consisting of a rather simple series of in vivo experiments, it became apparent that feeding protein antigens to macrophages resulted in a consistent and marked improvement in the immune response to the protein.<sup>1</sup>In other words, the lymphocytes
FURTHER CLINICAL STUDIES ON THE USE OF MERCUROCHROME AS A GENERAL GERMICIDE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEW DEVELOPMENT OF PLAGUE IN SAN FRANCISCO.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE POLITICAL RESPONSIBILITY OF THE PHYSICIAN.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatalities in the Peace Corps. A retrospective study: 1962 through 1983
Authors: S. W. Hargarten
Journal: JAMA (1985)

Fatalities among Peace Corps volunteers were analyzed for 1962 through 1983, with individual case histories reviewed for all deaths from 1977 through 1983. Unintentional injuries accounted for 70% of the 185 deaths of Peace Corps volunteers, with motor vehicle crashes the number 1 cause of death. The death rate from unintentional injuries for women was significantly higher than the comparable US rate. Motorcycles caused 12% of all Peace Corps deaths and 33% of all motor vehicle deaths. Suicide has emerged as a leading cause of death among volunteers, accounting for 13% of all deaths from 1981 through 1983. Greater emphasis on injury control measures is needed to reduce this toll. (<i>JAMA</i>1985;254:1326-1329)
Gastrointestinal Injuries From Magnet Ingestion in Children—United States, 2003-2006
Journal: JAMA (2007)

Ingestion of nonfood objects, inadvertently or intentionally, is common among young children and also occurs with older children and adolescents. Unless the objects are large or sharp, they usually pass through a child's digestive system without health consequences. However, the Consumer Product Safety Commission (CPSC) has become aware of toy products containing small, powerful rare-earth magnets that pose unique health hazards to children. Since 2003, CPSC staff members have identified one death resulting from ingestion of these magnets and 19 other cases of injuries requiring gastrointestinal surgery. This report describes three selected cases and summarizes the 20 cases of magnet ingestion identified by CPSC that occurred during 2003-2006. Caregivers should keep small magnets away from young children and be aware of the unique risks (e.g., volvulus and bowel perforation) that magnets pose if ingested. When evaluating children who have ingested objects, health-care providers should be aware of potential complications if magnets might be involved.
Infectious Disease and Dermatologic Conditions in Evacuees and Rescue Workers After Hurricane Katrina—Multiple States, August-September, 2005
Journal: JAMA (2005)

On August 29, 2005, Hurricane Katrina struck states along the Gulf Coast of the United States. In the days after the hurricane struck, approximately 750 evacuation centers were established in at least 18 states to accommodate more than 200,000 evacuees. State and local health departments, with assistance from CDC, initiated enhanced infectious disease surveillance and outbreak response activities, implemented by teams of public health and rescue workers, including military personnel. Outbreak monitoring included direct reporting of conditions of public health significance to public health agencies; daily contact between CDC and local public health officials; canvassing of reports from CDC, public health departments, and news media for potential infectious disease outbreaks; and investigation of reports of infectious disease with outbreak potential. This report summarizes infectious disease and dermatologic conditions reported during the first 3 weeks after the hurricane, before effective local surveillance was fully implemented. One outbreak of norovirus was reported among evacuees in Texas; no other outbreaks requiring unusual mobilization of public health resources were reported among evacuees or rescue workers.
Risk of fatal coronary heart disease in familial hypercholesterolaemia. Scientific Steering Committee on behalf of the Simon Broome Register Group.
Authors: Margaret Thorogood
Journal: BMJ (1991)

OBJECTIVES--(a) To determine the excess mortality from all causes and from coronary heart disease in patients with familial hypercholesterolaemia; (b) to examine how useful various criteria for selective measurement of cholesterol concentration in cardiovascular screening programmes are in identifying these patients. DESIGN--Prospective cohort study. SETTING--Eleven hospital outpatient lipid clinics in the United Kingdom. PATIENTS--282 men and 244 women aged 20-74 with heterozygous familial hypercholesterolaemia. MAIN OUTCOME MEASURE--Standardised mortality ratio, all adults in England and Wales being taken as standard (standardised mortality ratio = 100 for standard population). RESULTS--The cohort was followed up for 2234 person years during 1980-9. Fifteen of the 24 deaths were due to coronary heart disease, giving a standardised mortality ratio of 386 (95% confidence interval 210 to 639). The excess mortality from this cause was highest at age 20-39 (standardised mortality ratio 9686; 3670 to 21,800) and decreased significantly with age. The standardised mortality ratio for all causes was 183 (117 to 273) and also was highest at age 20-39 (standardised mortality ratio 902; 329 to 1950). There was no significant difference between men and women. Criteria for measurement of cholesterol concentration in cardiovascular screening programmes (family history, presence of myocardial infarction, angina, stroke, corneal arcus, xanthelasma, obesity, hypertension, diabetes, or any of these) were present in 78% of patients. CONCLUSIONS--Familial hypercholesterolaemia is associated with a substantial excess mortality from coronary heart disease in young adults but may not be associated with a substantial excess mortality in older patients. Criteria for selective measurement of cholesterol concentration in cardiovascular screening programmes identify about three quarters of patients with the clinically overt condition.
Chronic prostatitis.
Journal: BMJ (1972)

Chronic ProstatitisAcute infections of the prostate can usually be traced to a definite organism.But in most cases of chronic inflamma- tion the cause remains obscure.an organism can be isolated its sensitivities should be de- termined and an appropriate antibiotic administered for two to three weeks.If the condition relapses, which is common, treatment should be continued for several months, alterna- NO.
P1.01-97 Cluster Trial: Ph2 Biomarker-Integrated Study of Single Agent Alpelisib, Capmatinib, Ceritinib and Binimetinib in advNSCLC
Authors: Y. Wu, Q. Zhou, X. Zhang, H. Tu, B. Gan, B. Wang, C. Xu, H. Chen, M. Zheng, Z. Wang, X. Bai, Y. Sun, A. Myers, X. Lv, Y. Chakraborti, S. Zhao, J.-. Yang
Journal: Journal of Thoracic Oncology (2018)
Radiography of the AV shunt in hemodialysis
Authors: J. Chinitz
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Cannula failure continues to be a most vexing problem in maintenance dialysis. While this has prompted a trend toward the use of internal arteriovenous fistulae<sup>1,2</sup>it has also stimulated efforts toward improvement in shunt design.<sup>3,4</sup>To determine causes for progressive decrease in shunt flow or recurrent episodes of cannula clotting we have performed shunt contrast arteriography and venography in straight shunts with standard x-ray contrast media, methylglucamine diatrozoate-60%. Venous injection was well tolerated but rapid manual arterial injection was associated with excruciating burning pain of such a disagreeable nature that patients either outrightly refused repeat study or pleaded for general anesthesia. Five percent sodium chloride and 20% mannitol solutions gave identical pain on arterial injection. To minimize discomfort we diluted the contrast material with sterile distilled water in a three to one ratio, resulting in a 15% solution of methylglucamine diatrozoate with an osmolarity of
AMNESIA
Authors: GEORGE WILSON, CHARLES RUPP, WILLIAM W. WILSON
Journal: American Journal of Psychiatry (1950)

Amnesia or loss of memory for personal identification is a symptom which may occur in association with organic brain diseases, psychoses (particularly schizophrenia), and hysteria, and very frequently it is deliberately produced. Differentiation in respect to the responsible etiologic factor is sometimes facile, sometimes difficult. In addition to the presence of concomitant signs and symptoms, the structure of the amnesic defect and the character of the pre-amnesic personality may be helpful. If the amnesic episode serves as a means of escape from a difficult personal situation or the consequences thereof it is most likely simulated. Recovery is usually prompt and often spontaneous.
Tropical Medicine
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aeromonas hydrophila sepsis in a patient undergoing hemodialysis therapy
Authors: A. M. Ramsay
Journal: JAMA (1978)

<i>Aeromonas hydrophila</i>septicemia complicated by a generalized cutaneous vasculitis developed in a patient receiving home hemodialysis therapy. Because the<i>Aeromonas</i>organism is found in many natural water sources, the possibility that this patient's hemodialysis system became contaminated was explored. Although cultures from the patient's home environment showed no<i>Aeromonas</i>sp, the possibility still exists that the site of contamination was in the dialysis system. (<i>JAMA</i>239:128-129, 1978)
MEDICAL COLLEGES AND STATE PRACTICE ACTS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Facsimile of the First Edition of the Pharmacopoeia Augustana.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A multi-center randomized phase II study of nivolumab in combination with gemcitabine/cisplatin or ipilimumab as first line therapy for patients with advanced unresectable biliary tract cancer.
Authors: Vaibhav Sahai, Kent A. Griffith, Muhammad Shaalan Beg, Mark Zalupski
Journal: Journal of Clinical Oncology (2018)

TPS4142 Background: Patients (pts) with advanced biliary tract cancers (BTC) have poor prognosis with a median overall survival (OS) less than 12 months. This randomized, multi-institutional, phase 2, two-arm study is designed to investigate the role of combinational immunotherapy, using nivolumab with chemotherapy (gemcitabine/cisplatin) or as dual immunotherapy (nivolumab and ipilimumab) in pts with advanced BTC. Methods: Key eligibility criteria include histologically confirmed advanced, unresectable biliary adenocarcinoma (intrahepatic or extrahepatic and gallbladder) without prior systemic treatment, measurable disease per RECISTv1.1, ECOG PS 0-1, and absence of autoimmune disease and/or chronic steroid use. Primary objective is to evaluate the progression-free survival (PFS) rate at 6 months. Secondary objectives include evaluation of overall response rate (ORR) per immune related (ir)RECIST, median PFS and OS and safety in this patient population. Exploratory objectives include identification of biomarkers of response and mechanisms of resistance through serial (before, on and post therapy) biopsies and blood collection, including sequential whole exome/transcriptomic analysis and immune cell subset analysis (tissue and blood). Arm A therapy provides gemcitabine 1000 mg/m2, cisplatin 25 mg/m2 on days 1, 8 with nivolumab 360 mg on day 1 every 3 weeks for 6 months. In the absence of disease progression, pts may continue single agent nivolumab for up to 2 years. Arm B therapy includes nivolumab 240 mg every 2 weeks and ipilimumab 1 mg/kg every 6 weeks for up to 2 years in absence of disease progression. Accrual goal is 32 evaluable pts per arm. Using a null hypothesis value of 59% median PFS at 6 months, and an 80% alternative hypothesis, this ongoing study has > 80% power, with a one-sided alpha of 0.05 to identify treatment efficacy in one or both study arms. Clinical trial information: NCT03101566.
Award for Work Relating to Initial Stages of Cervical Cancer
Journal: JNCI Journal of the National Cancer Institute (1976)

Award for Work Relating to Initial Stages of Cervical Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 57, Issue 1, July 1976, Page 227, https://doi.org/10.1093/jnci/57.1.227-a Published: 01 July 1976
Abdominal Surgery
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1955)

LiverChild's67 monograph on the hepatic circulation and portal hypertension is an excellent summary of all known data on these subjects, together with an analysis of the published case reports of the various venovenal shunts performed to lower portal hypertension.Gall Bladder and Bile DuctsBiligrafinThe introduction of intravenous cholangiography has opened an entirely new avenue of diagnosis. Typical of many enthusiastic reports is one by Glenn et al.,68 regarding 80 patients, with delineation of the common duct in 53. The procedure was of no value in the presence of jaundice. The authors consider it indicated particularly in the . . .
Neurology, Minneapolis
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SACROCOCCYGEAL CHORDOMA
Authors: EDWIN F. HIRSCH
Journal: JAMA (1923)

Chordomas are tumors arising from remnants of the notochord. They are reported to occur at the two extremes of the vertebral column; namely, at the base of the skull along the clivus, and opposite the sacrum and coccyx. Luschka,<sup>1</sup>in 1856, recorded the first chordoma arising from the clivus. Virchow,<sup>2</sup>in 1857, made the first complete description, but thought the tissue was essentially cartilage with softening of the cartilage matrix and hydropic degeneration of the cells. In describing these cell changes he introduced the term "ecchondrosis physaliphora." His tumor, also, was located near the spheno-occipital synchondrosis. Müller,<sup>3</sup>in 1858, first suggested that these tumors may be of notochord origin, and that retained fragments of notochord tissue may be demonstrated in the basilar cartilage and sacrum of man and animals, and that in the fetus the notochord extends to the sella turcica. In the spheno-occipital synchondrosis it persists