tbuckley/cabot-search huggingface dataset:
Letter: Hazards of smallpox vaccination.
Authors: J Conard, M Samama, M Bousser, F Bories
Journal: BMJ (1976)

time in mice treated with bromocriptine we also started a study on the effect of this drug on platelets, coagulation, and fibrinolysis in man.Ten patients with Parkinson's disease (6 male, 4 female) were given bromocriptine because they had become unresponsive to levodopa.The dosage was started at 5 mg daily and increased every three days by 5 mg up to 20-25 mg, according to the tolerance.It is too early yet to publish the effect on Parkinson's disease.Haematological studies were per- formed on each patient the day before the start of treatment and 15 days later (when they were taking 20-25 mg per day).The following tests were done: bleeding time (Duke's and Ivy's methods), platelet count, thromboplastin time, partial thromboplastin time, euglobulin lysis time, and platelet aggregation with ADP (0-33-0-66-1-09-1-66 ,Lmol/l), adrenaline (0 82-4-10-41 umol/l), and collagen at different dilutions.No significant modification was observed in any of these measurements.In particular, it is to be noted that no enhancement of platelet aggregation was detected, even at low concentrations of aggregating agents.Our results show that patients with Parkin- sonism can take a clinically effective dose of bromocriptine without any change in platelets, coagulation, or fibrinolysis, even at doses twice as high as those used by
Microwave Ovens
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lead: A Case Study in Interagency Policy-Making
Authors: Irwin H. Billick
Journal: Environmental Health Perspectives (1981)

Exposures to low levels of lead in the environment are believed to have potentially significant health effects, especially in children; such exposures to the general population come from many sources. Responsibility for regulating lead exposures has been derived from a multitude of laws passed by the Congress, and thus ultimate protection of people depends on actions taken by several agencies of the federal government. For this reason, the history of efforts to reduce exposures to lead is an excellent case study in the way that federal agencies do or do not work well together. The issue of reduction of lead in gasoline is discussed in relation to the evidence generated by HUD concerning the relationship of blood lead in urban children in New York City to seasonal variations in consumption of leaded gasoline in that area. Some recommendations for developing interagency cooperation in such controversies are presented.
REPORT OF THE SURGICAL CLINICS.Held at the Western Pennsylvania Hospital, before the Students of the Western Pennsylvania Medical College.
Authors: J. B. MURDOCH
Journal: JAMA (1892)

[Reported by E. E. Wible, M.D., a member of the Graduating Class. (<i>Continued from page</i>354.) <i>November 29, 1890</i>. FRACTURE OF THE NECK OF THE FEMUR. This man fell from the top of a caboose in a railroad collision some time ago, and sustained an injury in the vicinity of the hip-joint. When he came in the hospital, we found the right leg rotated outwards, shorter than the other, and the foot everted. The latter symptom would point to a fracture of the femur; the shaft may be fractured, but that was excluded by not finding a false point of motion, hence we came to the conclusion that it was a fracture of the neck. Another symptom of fracture of the neck we find, is that the trochanter describes a smaller arc when rotated; for the reason that its centre of motion is the seat of fracture, while in the normal
Familial Aggregation of Coronary Artery Calcium in Families with Type 2 Diabetes
Authors: Lynne E. Wagenknecht, Carl D. Langefeld, Donald W. Bowden, J. Jeffrey Carr, Barry I. Freedman, Stephen S. Rich
Journal: Circulation (2001)

P11 Type 2 diabetes is recognized as a major risk factor for atherosclerotic cardiovascular disease including subclinical atherosclerosis as measured by non-invasive procedures. However, the role of genetic factors that contribute to various measures of subclinical atherosclerosis is largely unknown. We hypothesize that subclinical atherosclerosis, measured as coronary artery calcification (CAC), will be extensive in persons with type 2 diabetes, and that its presence depends on both genetic and environmental factors. The genetic factors will result in the familial aggregation of CAC. To determine the extent of familial aggregation of CAC in the presence of type 2 diabetes, we studied 122 persons with type 2 diabetes (mean age 60 years) and 13 persons without diabetes in 56 families. CAC was measured by fast gated helical computed tomography. Other measured factors included blood pressure, body size, lipids, HbA1c, and self-reported medical history. To test for an association between CAC and these factors while accounting for the potential familial correlation of CAC, generalized estimating equations were used. CAC was detectable in 80% of persons with diabetes (median score = 84, range 0 - 5776). Extent of CAC, adjusted for age, was associated with male gender (p=0.0003), reduced HDL (p=0.02), albumin-creatinine ratio (p=0.008), and cigarette pack-years (p=0.03). CAC was also associated with a history of angina, myocardial infarction, stroke and vascular procedure (all p&lt;0.01). HbA1c and fasting glucose were positively, but non-significantly associated with extent of CAC (p=0.14 and 0.08, respectively). CAC, adjusted for age, sex, race and diabetes status was heritable (h 2 = 0.50, p=0.009). In multivariate analysis adjusting for HDL, BMI, hypertension, and smoking, h 2 = 0.40 (p=0.038). These results suggest that strong (independent) genetic factors as well as environmental factors contribute to the variance of CAC in persons with type 2 diabetes. In these data, CAC appears heritable and may serve as an important feature in designing studies to map genes contributing to both atherosclerosis and type 2 diabetes.
SPASMUS NUTANS.
Authors: I. A. ABT
Journal: JAMA (1900)

Spasmus nutans is a disease which was first described by Romberg<sup>1</sup>and Henoch<sup>2</sup>, and which appears in the literature under a variety of names: head-nodding, rotatory and rhythmic spasms. Gyrospasm of the head is a term which Peterson<sup>6</sup>has applied to the rotatory variety of the disease. Two cases of spasmus nutans have come under my observation, which I desire to report. <h3>Case 1.</h3> —B. R., aged 9 months, was sent to the Michael Reese Hospital, Feb. 15, 1898. <i>Family history:</i>The father is living and well. The mother is a dwarf and has borne five children; two are dead; one is said to have died of pneumonia at the age of 11 months; the other, a male child, died at the age of 7 months, after an operation had been performed on its head for some disease the nature of which was not known to the
Massive acute pulmonary embolism. The deceivingly nonspecific manifestations
Authors: N. K. Wenger
Journal: JAMA (1972)

Signs, symptoms, and laboratory data to support the diagnosis of pulmonary embolism are often deceivingly nonspecific. Ninety patients with documented massive pulmonary embolism had few clinical and laboratory findings traditionally described for pulmonary infarction; only 62% had pleuritic chest pain, 27% had hemoptysis, and 17% had a pleural rub. Fifteen percent had a normal x-ray film of the chest, and only 31% had an electrocardiogram typical of acute cor pulmonale. Fifty-eight percent presented without phlebitis. Dyspnea was the most frequent symptom (80%), and most patients had a well-defined condition, predisposing them to pulmonary embolism.
Note from the editors: Eurosurveillance stops regular production and distribution of hard copies
Journal: Eurosurveillance (2014)

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Tons of work go into CDC's ounces of prevention
Authors: M. F. Goldsmith
Journal: JAMA (1990)

"THE IMMUNIZATION program in the United States is an extraordinary success story," says Alan R. Hinman, MD, director of the Center for Prevention Services. "As a result of widespread use of vaccine in childhood, we are now at record or near-record low levels for most of the vaccine-preventable diseases." Making sure that record stands is the main task of this center, one of the larger ones at the CDC, with nearly 1000 employees and $400 million per year for prevention programs. More than half the center's employees work outside Atlanta, assigned as public health advisors to state and local health departments. Carrying out research and surveillance of disease patterns across the country helps the center to develop interventions. Through technical and financial assistance, the center helps states and cities to implement the interventions and to coordinate their activities. The center also evaluates the impact of these programs. "Success in immunization requires an adequate information base," says Walter A. Orenstein, MD, director of the
THE PROPOSED VIRGINIA ANTI-KISSING LAW.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Racial and Ethnic Factors in Outcomes of Children With Acute Lymphoblastic Leukemia—Reply
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Graves' disease following irradiation for Hodgkin's disease
Authors: M. V. Pilepich
Journal: JAMA (1978)

THE THYROID gland is commonly included in the radiation field in patients with Hodgkin's disease treated with radiation therapy. The so-called mantle field routinely includes the neck. A substantial number of patients with non-Hodgkin's lymphoma, head and neck tumors, and breast carcinoma also receive neck irradiation. The thyroid was traditionally considered a radioresistant organ. However, several reports on thyroid dysfunction following neck irradiation have appeared in recent years. Glatstein et al<sup>1</sup>reported a 44% incidence of elevated serum thyroid-stimulating hormone (TSH) concentration in patients with lymphomas who had lymphangiography and received neck irradiation. In 11% of these patients, clinical hypothyroidism or evidence of thyroid hypofunction (according to laboratory tests other than serum TSH determination) developed. Although the exact incidence and pathogenesis are not known, hypothyroidism is a recognized complication of thyroid irradiation. Graves' disease following thyroid irradiation, manifested either as hyperthyroidism or ophthalmopathy, is not a well-recognized entity. <h3>Report</h3>
FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia
Authors: Hana Raslova, Emiko Komura, Jean Pierre Le Couédic, Frederic Larbret, Najet Debili, Jean Feunteun, Olivier Danos, Olivier Albagli, William Vainchenker, Rémi Favier
Journal: Journal of Clinical Investigation (2004)

Paris-Trousseau syndrome (PTS; also known as Jacobsen syndrome) is characterized by several congenital anomalies including a dysmegakaryopoiesis with two morphologically distinct populations of megakaryocytes (MKs). PTS patients harbor deletions on the long arm of chromosome 11, including the FLI1 gene, which encodes a transcription factor essential for megakaryopoiesis. We show here that lentivirus-mediated overexpression of FLI1 in patient CD34+ cells restores the megakaryopoiesis in vitro, indicating that FLI1 hemizygous deletion contributes to the PTS hematopoietic defects. FISH analysis on pre-mRNA and single-cell RT-PCR revealed that FLI1 expression is mainly monoallelic in CD41+CD42– progenitors, while it is predominantly biallelic in the other stages of megakaryopoiesis. In PTS cells, the hemizygous deletion of FLI1 generates a subpopulation of CD41+CD42– cells completely lacking FLI1 transcription. We propose that the absence of FLI1 expression in these CD41+CD42– cells might prevent their differentiation, which could explain the segregation of the PTS MKs into two subpopulations: one normal and one composed of small immature MKs undergoing a massive lysis, presumably originating from either FLI1+ or FLI1– CD41+CD42– cells, respectively. Thus, we point to the role of transient monoallelic expression of a gene essential for differentiation in the genesis of human haploinsufficiency-associated disease and suggest that such a mechanism may be involved in the pathogenesis of other congenital or acquired genetic diseases.
Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay
Authors: H Tsubouchi
Journal: Hepatology (1991)

We have found a hepatotrophic factor in plasma or sera of patients with fulminant hepatic failure and have purified human hepatocyte growth factor from plasma of these patients. In this study we developed an enzyme-linked immunosorbent assay with high specificity and sensitivity for human hepatocyte growth factor in human serum. This assay for serum human hepatocyte growth factor is a sandwich method consisting of three steps. The standard curve for human hepatocyte growth factor appeared to be linear in the range of 0.20 to 12.50 ng purified human hepatocyte growth factor/ml (2.35 to 147 pmol/L). The assay took about 4 hr. Serum human hepatocyte growth factor values in patients with fulminant hepatic failure measured by enzyme-linked immunosorbent assay showed a strong positive correlation with that by bioassay using rat hepatocytes in primary culture. The mean value of serum human hepatocyte growth factor for 30 normal subjects was 0.24 ± 0.12 (S.D.) ng/ml that for 23 patients with fulminant hepatic failure was 8.06 ± 1.76 (S.E.M.) ng/ml - > 30 times greater than the mean value for normal subjects. Serum human hepatocyte growth factor levels in patients with acute hepatitis, chronic hepatitis and cirrhosis were found to be slightly higher than those in normal subjects, but only the increase in serum human hepatocyte growth factor of acute hepatitis patients was statistically significant. The enzyme-linked immunosorbent assay for serum human hepatocyte growth factor should prove useful for serum human hepatocyte growth factor level measurement in patients with various liver diseases. (HEPATOLOGY 1991;13:1–5).
BERLIN
Journal: JAMA (1933)

<h3>New Regulations Concerning Vivisection</h3> In 1930, new regulations were established in Prussia, which permitted experiments on living animals only for purposes of important research, and then only under prescribed conditions, with avoidance of superfluous experiments for demonstration purposes, for which film presentations might be substituted. All serious-minded scientific investigators supported this ministerial order (The Journal, Aug. 13, 1932, p. 574). August 17, Göring, chairman of the Prussian ministerial cabinet, issued an order to go into effect immediately that "vivisection of animals of whatsoever species is prohibited in all parts of Prussian territory. The chairman of the cabinet has instructed the ministries to present to him without delay the text of a law incorporating this provision. Until the promulgation of this law, persons who engage in vivisection of animals of any kind will be removed to a concentration camp." The applications to serious scientific research will be defined and explained in
Travel Notes.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vaginal Temperature
Authors: G. I. M. Swyer
Journal: BMJ (1947)

MBRITISHThirdly, the evidence from Brixton prison appears to support the alleged connexion between natural homosexuality and sexual perversion, which is the view put forward by Sir Norwood East and W. H. Hubert2 and Clifford Allen,4 and opposed by Havelock Ellis and others.J. A. Symonds (in an unpublished essay) admits that, although " a far larger proportion of mental disturbance and nervous hypersensitivity can he proved in Urnings than in normal men, in a vast majority of cases the Urning owing to present laws and social prejudices cannot, like other men, obtain a simple and easy satisfaction of his inborn sexual desires, which for him are as natural as swimming to a fish.It is this forcible suppression of an instinct so deeply rooted in his nature which originates the morbid symp- toms that may often be observed in the Urning."The same author attributes to homosexual fears *and guilt " at least half of the suicides of young men."Bernard Shaw has stated
Smoking withdrawal in hospital patients: factors associated with outcome. Subcommittee of the Research Committee of the British Thoracic Society.
Authors: I Campbell, Sully Hospital
Journal: Thorax (1984)

Abstract Factors associated with outcome were investigated in the British Thoracic Society's study of smoking withdrawal in 1550 patients attending hospital with smoking related diseases. A long term abstinence rate of 9.7% was found. Men did better than women, 12.2% of them succeeding in stopping smoking compared with 5.3% of the women. Success rate increased with age, and people with heart disease did better than those with any other diagnosis. The success rate of the best group, men with heart disease, was 21%. Sex, age, and diagnosis appeared to act independently. If the most important other person in the patient's life was a non-smoker success was more likely. Weight increased by an average of 5.9 kg over a year in those who stopped smoking.
Transactions of the Iowa State Medical Society
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal