tbuckley/cabot-search huggingface dataset:
Randomized trial with ICE (ifosfamide, carboplatin, etoposide) plus whole body hyperthermia versus ICE chemotherapy for malignant pleural mesothelioma
Authors: A. Bakhahandeh, G. Wiedemann, P. Zabel, K. Dalhoff, T. Kohlmann, R. Zumschlinge, D. Penzel, T. Wagner, S. Peters
Journal: Journal of Clinical Oncology (2004)

7288 Background: Previously, we have reported the results of phase II trial with ICE w/ Whole body hyperthermia (WBH) for malignaunt pleural mesothelioma (MPM), showing a 1 year survival of 68%, a median survival of 19.1 months and a progression free survival of 7.4 months in 25 evaluable pts. These pts had achived PR:20%, MR:12%, NC:44% and PD:24% of cases. These promising results are consistent with continued clinical investigation as a randomized clinical trial. Methods: In this randomized trial we compare ICE (ifosfamide 4.5 g/m2, day1; carboplatin 270 mg/m2, day1; etoposide 135 mg/m2, day2 and 3 and neulasta, day 4, w/ or w/o WBH, every 4 weeks for pts with MPM. Results: From 2001 to 2003, 31 chemonäive pts were enrolled. 27pts are evaluable for response, 14 pts randomized to ICE w/ WBH, 13 pts to ICE. Median age is 58 year and WHO PS 0-II. Response rates (PR+NC) for ICE w/ WBH are 72% (PR:15%; NC:57%) and for ICE are 69% (PR:31%; NC:38%). Major treatment toxicites include grade 3/4 neutropenia (ICE w/WBH: 36%; ICE: 30%) and thrombocytopenia (ICE w/WBH: 37.7% and ICE: 15.3%). The median survival for all pts is for ICE w/WBH: 345 days versus ICE: 451 days and a progression free survival for ICE w/ WBH: 167 versus ICE: 275 days, respectively. Conclusions: ICE chemotherapy is a active regimen for MPM. Although a phase II study for ICE w/WBH showed good results, this randomized study moderate good responeses for ICE w/o WBH.This preliminary data from a randomized study show little, it any, beneficial effect mediated through hyperthermia. Conclusive judgement has to be postponed until completion of this trial. Support: The Cancer Research Institute, Inc. NYC, NY; Hauptverband der gewerblichen Berufsgenossenschaften, St. Augustin, Germany. No significant financial relationships to disclose.
Internal Medicine
Authors: Frank D. Gray
Journal: JAMA (1980)

Now is a good time, as we finish one decade and start a new one, to take stock of how internal medicine has fared. But to identify the single most important idea or event of a decade is a task I face with considerable awe. However, one outstanding trend has been the redirection of our focus from organs and tissues to cells. The change began long before the 1970s, but it became pervasive during this decade. Cellular and molecular biology is now a clinical reality to the physician at the bedside. The biologic concept of the cell has been with us more than two centuries, and the idea that the cell is a focus of disease germinated at approximately the time Virchow published his treatise on cellular pathology slightly more than 100 years ago. The first half of the 20th century saw little progress in clinical concepts of the cell,
Panic Attack
Authors: John Pidgeon
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Children's Joint Committee.
Journal: BMJ (1978)

Based on data collected from 20,000 IUD users in Britain, it is suggested that the device not be the 1st choice of nulliparous women. Rekindled concern with long-term consequences of IUD use, raised incidence of pregnancy, expulsion of the device, bleeding or pain in nulliparous vs. parous users, and raised incidence of pelvic disease are discussed. The link between IUD use and pelvic inflammatory disease is bolstered by data showing a 3-fold increase in salpingitis in IUD users compared with women in general. When controlled for parity, a 7-fold increase in pelvic inflammation exists in nulliparous IUD users vs. nulliparous nonusers. Subsequent miscarriage and ectopic pregnancy in users vs. nonusers are special problems in women using the device as a means of delaying 1st pregnancy. A controlled prospective study is called for, since pelvic infection may affect subsequent fertility.
Notes on the package insert
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SPECIAL DIETARY FOODS AND THE LAW
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nostra culpa!
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physical Properties of Five Grain Dust Types
Authors: Calvin B. Parnell, David D. Jones, Ross D. Rutherford, Kerry J. Goforth
Journal: Environmental Health Perspectives (1986)

Physical properties of grain dust derived from five grain types (soybean, rice, corn, wheat, and sorghum) were measured and reported. The grain dusts were obtained from dust collection systems of terminal grain handling facilities and were assumed to be representative of grain dust generated during the handling process. The physical properties reported were as follows: particle size distributions and surface area measurements using a Coulter Counter Model TAII; percent dust fractions less than 100 micron of whole dust; bulk density; particle density; and ash content.
Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells
Authors: Yoshiyuki Takahashi, Nanae Harashima, Sachiko Kajigaya, Hisayuki Yokoyama, Elena Cherkasova, J. Philip McCoy, Ken-ichi Hanada, Othon Mena, Roger Kurlander, Abdul Tawab, Ramaprasad Srinivasan, Andreas Lundqvist, Elizabeth Malinzak, Nancy Geller, Michael I. Lerman, Richard W. Childs
Journal: Journal of Clinical Investigation (2008)

During the preparation of the manuscript, the definition of the error bars was inadvertently omitted.In all figures, error bars indicate SEM.
Infectious diseases in competitive sports
Authors: J. M. Dorman
Journal: JAMA (1994)

<h3>In Reply.</h3> —The many public and private health care providers and outreach workers of New York State and NYC are to be congratulated for achieving a more than 10-fold increase in DOT for TB patients in NYC in just 2 years.<sup>1</sup>It is critical that this effort be sustained. While attributing any decline in secular trends to a specific intervention must be done cautiously, the role of DOT in the dramatic 15% decrease in reported TB cases from 1992 to 1993 (from 3811 to 3235) must be strongly considered. It will be important to further document their success by evaluating completion rates in patients with and without this intervention. At the same time, the use of DOT in NYC was not the only intervention. It was part of an individualized patient treatment plan that also provided accessible services, a reliable source of medication, treatment in a variety of settings,
Immunologic aspects of endocrine diseases
Authors: J. N. Fink
Journal: JAMA (1982)

ENDOCRINE organs, with their highly specialized functions, contain organ-specific tissue antigens capable of inducing autoimmune responses under appropriate conditions. Some of the endocrine diseases with autoimmune phenomena are listed in Table 13-1. Immunologic aspects of the diseases listed in this table are discussed in this chapter. <h3>THYROID DISEASES</h3><h3>Hashimoto's Thyroiditis</h3> Hashimoto's or autoimmune thyroiditis is a common disease. The incidence, now 1% to 2% at autopsy, appears to be increasing. The incidence increases with age, is four times more common in women than men, and four times more common in white than black persons. There may be familial aggregations of the disease, although this tendency is not so marked as with Graves' disease. To date, there is no conclusive evidence of any association with HLA or bloodgroup antigens. <h3>Pathology</h3> In the thyroid gland there are variable degrees of depletion of colloid from the follicles, Askenazy's cellchange, infiltration with lymphocytes, germinal-center
Factors associated with fulminant liver failure during an outbreak among injection drug users with acute hepatitis B
Authors: Richard S Garfein, William A Bower, Cherry M Loney, Yvan J F Hutin, Guo-Liang Xia, Jaspaul Jawanda, Amy V Groom, Omana V Nainan, James S Murphy, Beth P Bell
Journal: Hepatology (2004)

Death related to acute hepatitis B occurs in approximately 1% of patients. We investigated an outbreak of hepatitis B virus (HBV) infections among injection drug users (IDUs) resulting in several deaths. We conducted a case-control study of fulminant (case patients) and nonfulminant (control patients) HBV infections. We directly sequenced the entire HBV genome from fulminant and nonfulminant cases. From October 1998 to July 2000, 21 acute HBV infections, including 10 fulminant hepatitis B cases, were identified. The median age was 30 (range, 18-49) years, 12 (57%) were female, 20 (95%) were American Indians, and 20 (95%) reported injecting illicit drugs. All patients with fulminant hepatitis B died (case-fatality rate = 47.6%). Case patients (n = 5) and control patients (n = 9) were similar with respect to age, sex, race, and hepatitis C virus serostatus. All case patients used acetaminophen during their illness compared with 44% of control patients (P =.08). Compared with control patients, case patients lost more weight in the 6 months before illness (P =.04); during their illness, they used more alcohol (P =.03) and methamphetamine (P =.04). All 9 isolates sequenced were genotype D, shared 99.7% homology, and included mutations previously described in association with fulminant hepatitis B. In conclusion, a high prevalence of exposure to factors potentiating hepatic damage with acute hepatitis B contributed to the outbreak's high mortality rate; mutations present in the outbreak strain might also have been a factor. Improved vaccination coverage among IDUs has the potential to prevent similar outbreaks in the future.
Editorial Board
Authors: George Bartley, Stephen Mcleod, San Francisco, Henry Jampel, Anita Agarwal, T Iqbal, Ike Ahmed, Jayakrishna Ambati, Tin Aung, Singapore Bengtsson, James Brandt, Wiley Chambers, Balwantray Chauhan, Emily Chew, Michael Chiang, Daniel Albert, Mary Cotch, Helen Danesh-Meyer, Marjan Farid, Steven Gedde, Lynn Gordon, Los Angeles, Mingguang He, Bennie Jeng, Tianjing Li, Sue Lightman
Journal: Ophthalmology (2017)
Andrew Jones
Authors: Yacine Zerguini, Donald Kirkendall, Astrid Junge, Jiri Dvorak
Journal: British Journal of Sports Medicine (2007)

Objective: Ramadan is a period of daylight abstention from liquid or solid nutrients.As sports continue to be scheduled, an understanding of the effects of Ramadan on Muslim athletes is warranted.Design: Two Algerian professional soccer teams (55 men) were studied.Field tests of physical and soccer performance were collected before, at the end and 2 weeks after Ramadan in 2004.Players were queried on sleeping habits and personal perception of training and match performance.Setting: Field setting at club training ground.Main outcome measures: Performance on fitness and skill tests.Results: Performance declined significantly (p,0.05) for speed, agility, dribbling speed and endurance, and most stayed low after the conclusion of Ramadan.Nearly 70% of the players thought that their training and performance were adversely affected during the fast.Conclusions: The phase shift of food intake and disruption of sleep patterns affect actual and perceived physical performance.Islamic athletes need to explore strategies that will maximise performance during Ramadan.
Error in Wording in the Abstract and Methods Section and Reworded Figure 2 Title and Caption
Authors: Guillaume Leurent
Journal: JAMA Internal Medicine (2016)

Stacey L. Sheridan, MD, MPH; Anne Sutkowi-Hemstreet, MPH; Colleen Barclay, MPH; Noel T. Brewer, PhD; Rowena J. Dolor, MD, MHS; Ziya Gizlice, PhD; Carmen L. Lewis, MD, MPH; Daniel S. Reuland, MD, MPH; Carol E. Golin, MD; Christine E. Kistler, MD, MASc; Maihan Vu, DrPH; Russell Harris, MD, MPH
Active Immunizations
Authors: John S. Taub, Robert J. Haggerty
Journal: New England Journal of Medicine (1963)

PoliomyelitisThe safety and effectiveness of both the killed (Salk) and the live oral (Sabin) poliovirus vaccines have now been established clinically. Statewide programs are going forward to immunize large segments of the population against poliomyelitis with the latter. Such mass campaigns are useful in initiating population-wide immunity,11 but the new crop of infants who enter the susceptible phase will probably require individual immunization for protection.EffectivenessSalk poliovaccine has been extremely effective in reducing, by approximately 90 per cent, the incidence of paralytic poliomyelitis. Nonetheless, paralytic poliomyelitis has continued to occur in both immunized and unimmunized persons. In a . . .
Cystic fibrosis transmembrane conductance regulator mediates the cyclic adenosine monophosphate-induced fluid secretion but not the inhibition of resorption in mouse gallbladder epithelium
Authors: R Peters
Journal: Hepatology (1997)

We have studied the physiological role of the cystic fibrosis (CF) gene product (cystic fibrosis transmembrane conductance regulator [CFTR]) in gallbladder epithelium using a knockout mouse model for CF. We found that normal mouse gallbladder epithelium expresses functional CFTR as shown by reverse-transcription polymerase chain reaction (RT-PCR) analysis and Ussing chamber experiments. Gallbladders from Cftr −/− mice were structurally intact as shown by microscopic and physiological parameters but lacked the cyclic adenosine monophosphate (cAMP)-induced chloride current observed in normal gallbladders. In fluid transport measurements, normal and Cftr −/− gallbladders were equally active in basal resorption. The addition of forskolin, which activates CFTR anion channel activity through the cAMP system, resulted in net fluid secretion in normal gallbladders. In contrast, Cftr −/− gallbladders were unable to secrete fluid while a complete inhibition of resorption by forskolin was observed. We conclude that, in normal mouse gallbladder epithelium, cAMP-induced fluid secretion involves simultaneous inhibition of apical sodium chloride resorption and activation of CFTR. Our data support the hypothesis that gallbladder disease in CF is at least in part caused by a deficient secretory response to the endogenous cAMP-linked hormones VIP and secretin.
Health Care Financing Administration receives plenty of comments on laboratory proposals
Authors: C. Marwick
Journal: JAMA (1990)

THE CLINICAL laboratory world is up in arms over the proposed regulations issued by the Health Care Financing Administration and aimed toward implementing the Clinical Laboratory Improvement Amendments of 1988. At a meeting, hastily convened in Washington, DC, by the National Committee for Clinical Laboratory Standards, more than 300 physicians, laboratorians, public health administrators, and well over 100 industry representatives virtually unanimously denounced the proposals as unrealistic, certain to be expensive, likely in some instances to interfere with medical care, and unlikely to be cost effective. The committee (which is not a government body) is an interdisciplinary organization that promotes the development of voluntary standards for clinical laboratory testing. Its membership includes medical laboratory professional associations, agencies of the federal and state governments, manufacturers of laboratory equipment and products, and individual laboratories and healthcare institutions. The Health Care Financing Administration had asked for detailed responses to its proposals. The laboratory
Headache
Authors: Manisha Bhide
Journal: Annals of Internal Medicine (2008)

On Being a Doctor3 June 2008HeadacheManisha Bhide, MDManisha Bhide, MDFrom University of Colorado Health Sciences Center, Commerce City, CO 80022.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-11-200806030-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Asra came to me with a headache. She was a well-built, middle-aged woman with close cropped hair graying at the temples. Her eyes engaged my attention. They were brown, deep-set with dark circles. She had a pinched expression on her face as if her temporal muscles were in eternal spasm.I thought I was well equipped to handle any headache. I knew about temporal arteritis and regarded myself as an expert in peering through undilated pupils to check for papilledema. I was adept at recognizing the red flags of projectile vomiting, morning headache, and neck stiffness. I had triptans and ... Author, Article, and Disclosure InformationAffiliations: From University of Colorado Health Sciences Center, Commerce City, CO 80022.Corresponding Author: Manisha Bhide, MD, 11763 Hannibal Street, Commerce City, CO 80022; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 June 2008Volume 148, Issue 11Page: 882KeywordsEmergency departmentHeadachesMigraineMusclesSigns and symptomsSleepStiffnessSyncopeTemporal arteritisVomiting ePublished: 3 June 2008 Issue Published: 3 June 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Deaths from acute appendicitis in children continue to fall
Journal: BMJ (2001)

Low dose liposomal amphotericin B seems to be effective against visceral leishmaniasis Low dose liposomal amphotericin B given as a single dose or short five day course seems effective against visceral leishmaniasis in India.Recommended regimens of liposomal amphotericin are prohibitively expensive in developing countries, but in a pilot study on 91 patients, Sundar et al (p 419) found cure rates of 92% with a dose of 5 mg/kg given either as a single infusion or over five days.If proved effective in larger trials, low dose regimens should help make the drug more affordable.
A MACROSCOPIC AGGLUTINATION METHOD IN CAPILLARY TUBES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal