tbuckley/cabot-search huggingface dataset:
Do cervical smears save lives?
Journal: BMJ (1969)

PointersVaricose Veins: Comparison between British and Egyptian women cotton workers revealed higher prevalence in the former, and also a significant relation to environmental factors such as standing all day and wearing tight corsetry (p.591).Stress in Acute Illness: Study of 178 patients suggests that a plasma 11 -OHCS level of less than 15 JLg./100 ml.indicates an inadequate adrenal cortical response in patients with severe infection (p.595).Prostatic Obstruction: In patients with benign
FEDERATION OF STATE MEDICAL BOARDS
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gatekeeping Reconsidered
Authors: David Lawrence
Journal: New England Journal of Medicine (2001)

In this issue of the Journal, Ferris et al.1 report on the experience of Harvard Vanguard Medical Associates, a multispecialty prepaid group practice, after it eliminated a gatekeeping system that had been in place for more than 25 years. During the first 18 months after the elimination of the requirement that referrals for specialty care be obtained from primary care physicians, there was little evidence of change in the use of specialty services by adults.The study by Ferris et al. was well done and provides valuable data. It sheds light on an often misunderstood subject. Some caution, however, is . . .
光化性角化病的管理:全科医生和皮肤科医生的定性访谈研究
Authors: E.C. Noels, M. Lugtenberg, S. van Egmond, S.M. Droger, P.A.J. Buis, T. Nijsten, M. Wakkee
Journal: British Journal of Dermatology (2019)

光化性角化病 (AK) 是浅色皮肤的人因为长期暴露在阳光下而引起的粗糙的皮肤损伤(斑块),它影响 24‐60% 的 50 岁以上人群。目前对 AK 患者的管理(即他们如何被诊断和治疗,以及他们被“随访”多久)似乎在初级护理(如全科医生)和二级护理(如医院皮肤科)之间存在差异。这项荷兰的研究旨在深入了解当前 AK 管理的潜在动机。研究人员对 22 名全科医生和 18 名皮肤科医生进行了访谈。由于缺乏知识和经验以及对 AK 护理的认知价值较低,全科医生在诊断 AK 和确定治疗和随访计划方面的方法各不相同。皮肤科医生表示,他们努力根据官方指南提供 AK 治疗,但患者偏好和其他患者相关因素会影响治疗选择,并且经常会导致粗放式的随访方案。为了使 AK 护理在荷兰初级护理中变得更加标准化和统一,需要实施指南和持续教育,以解决普遍报道的全科医生缺乏价值、经验和知识的障碍。为了帮助预防二级护理中的粗放式随访(因此确保有效使用护理),共享决策工具和足够的患者信息可能有助于皮肤科医生管理患者的偏好。
Infections Caused by<i>Gordonia</i>Species at a Medical Center in Taiwan, 1997 to 2008
Authors: C. C. Lai, C. Y. Wang, C. Y. Liu, C. K. Tan, S. H. Lin, C. H. Liao, C. H. Chou, Y. T. Huang, H. I. Lin, P. R. Hsueh
Journal: Clinical Microbiology and Infection (2009)
Chris' Tears
Authors: William M Tierney
Journal: Annals of Internal Medicine (2011)

On Being a Doctor1 November 2011Chris' TearsWilliam M. Tierney, MDWilliam M. Tierney, MDFrom Regenstrief Institute, Indiana University School of Medicine, Indianapolis, IN 46202.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-9-201111010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail As soon as I arrived for morning rounds, the resident pulled me aside and said, “You need to talk to Chris.”“Why?”“Mr. Simons died last night, and Chris took it pretty hard. He was crying.”I was attending on the inpatient medicine service of our VA hospital and had come in for Saturday morning rounds. Chris was a medical student on the first clinical rotation of his junior year. When he started his rotation, one of the patients he picked up was Mr. Simons. At 6 feet, 5 inches, Mr. Simons had been a big, strong farmer. Even into ... Author, Article, and Disclosure InformationAffiliations: From Regenstrief Institute, Indiana University School of Medicine, Indianapolis, IN 46202.Corresponding Author: William M. Tierney, MD, Regenstrief Institute, 1050 Wishard Boulevard, Suite RG6, Indianapolis, IN 46202; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 2011Volume 155, Issue 9Page: 644KeywordsHospital medicineIntensive care unitsIschemiaKidneysMorphineMyocardial infarctionNephrectomyPatientsRenal cancerStroke ePublished: 1 November 2011 Issue Published: 1 November 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
BAL
Authors: Raymond V. Randall, Albert O. Seeler
Journal: New England Journal of Medicine (1948)

ArsenicStocken and Thompson39 found that the topical application of BAL to lewisite burns was followed by an increase in the urinary excretion of arsenic. These authors then demonstrated that parenteral administration of BAL saved rats poisoned by the application of lethal amounts of lewisite to the body surface. Harrison and his co-workers40 concluded from their experiments on dogs that the most effective way to treat extensive lewisite burns was to use BAL ointment to combat the local skin effects of lewisite, and, at the same time, to use the compound parenterally to combat the effects of the absorbed arsenic. . . .
Greater IUD perforation risk, lactation linked
Authors: B. Merz
Journal: JAMA (1983)

Women who have an intrauterine device (IUD) inserted during lactation run a tenfold greater risk of uterine perforation than do nonlactating women, according to a nine-center Women's Health Study. The study, organized to examine various complications of IUD use, was supported by the National Institute of Child Health and Human Development, Bethesda, Md. Results of this phase of the investigation were generated from a study group of 32 women hospitalized for uterine perforation necessitating transperitoneal IUD removal and a control group of 497 women, matched by age and race, who had worn IUDs uneventfully for a mean period of 15 months (<i>Obstet Gynecol</i>1983;61:31-36). Thirty-one women (97%) in the study group had given birth, compared to 337 (68% ) in the control group. Because the correlation between parity and uterine perforation was so strong, the investigators restricted further analysis to women in both groups who had borne children. They then determined
A Textbook of Bacteriology with a Section on Pathogenic Protozoa. The Application of Bacteriology and Immunology to the Etiology, Diagnosis, Specific Therapy and Prevention of Infectious Diseases for Students and Practitioners of Medicine and Public Health
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of hepatocyte growth factor, transforming growth factor alpha, and transforming growth factor beta 1 messenger RNA in various human liver diseases and correlation with hepatocyte proliferation
Authors: M Masuhara
Journal: Hepatology (1996)

Hepatocyte growth factor (HGF) and transforming growth factor alpha (TGF-alpha) stimulate liver regeneration, whereas transforming growth factor beta 1 (TGF-beta 1) inhibits it in rats. However their significance in human liver diseases, especially in severe acute liver injury, remains unclear. We studied HGF, TGF-alpha, and TGF-beta 1 messenger RNA (mRNA) expression in the livers of patients with live diseases using a competitive reverse transcriptase polymerase chain reaction. As little as a twofold difference in mRNA expression could be detected from minute liver biopsy samples. We then examined cell proliferation using proliferating cell nuclear antigen (PCNA) staining. HGF mRNA levels were significantly higher (approximately threefold) in acute hepatitis (AH) than in exacerbation of chronic liver disease (EX) (P < .05). TGF-alpha mRNA levels were significantly greater in AH (approximately twofold) than EX (P < .05), and the levels were significantly higher (approximately threefold) in chronic hepatitis (CH) than in EX (P < .05). The TGF-beta 1 mRNA levels in all the groups were not significantly different. In acute liver injury (AH and EX), there was a significant correlation between HGF mRNA expression and the PCNA labeling index (LI) in the liver (r = .87, P < .0005). TGF-alpha mRNA expression also correlated with the PCNA LI (r = .92,P < .0001). There was no significant correlation between the serum HGF and the PCNA LI in the liver. In conclusion, HGF and TGF-alpha produced in the liver stimulate hepatocyte proliferation in response to acute liver injury in humans. (Hepatology 1996 Aug;24(2):323-9)
THE CLEVELAND SESSION
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pemphigus
Authors: Thomas T. Provost
Journal: New England Journal of Medicine (1982)

Pemphigus is a general term for a group of skin diseases characterized by intraepidermal blistering as a result of loss of normal adhesion between cells (acantholysis). There are four recognized forms of pemphigus: pemphigus vulgaris, pemphigus vegetans, pemphigus foliaceus, and pemphigus erythematosus. These diseases have distinctive clinical and histological features but have in common the presence of autoantibodies reactive against epidermal intercellular cement.Pemphigus vulgaris, the most common form of pemphigus in North America, is characterized by flaccid blister formation occurring on normal-appearing skin and mucous membranes (e.g., the mouth, esophagus, and vagina). These blisters rupture when subjected to shearing, . . .
Behavioral Toxicity of Trihalomethane Contaminants of Drinking Water in Mice
Authors: Robert L. Balster, Joseph F. Borzelleca
Journal: Environmental Health Perspectives (1982)

The behavioral toxicity of trichloromethane (TCM), dichlorobromomethane (DCBM), dibromochloromethane (DBCM) and tribromomethane (TBM) was evaluated following oral administration in mice. A variety of dosage regimens and behavioral measures were used. Studies included acute dose effect, 14-and 90-day treatments at 300 and 3000 times the estimated average human daily intake of contaminated drinking water, 30 days of 100 mg/kg/day, and 60 days of 100 and 400 mg/kg/day. In addition, TCM was tested for the production of taste aversions with 10-day administration and for behavioral teratology in offspring following extensive perinatal exposure. The ED50 for acute effects on a screen test of motor performance was about 500 mg/kg for all four trihalomethanes. The 14-day treatments had no effect on swimming behavior and the 90-day treatments had no effect on bar clinging, a test of motor coordination, and a measure of exploratory behavior. None of the compounds produced effects on passive-avoidance learning following 100 mg/kg/day for 30 days. TCM, DBCM and TBM elicited clear effects at both 100 and 400 mg/kg/day on operant behavior when administered for 60 days. DBCM elicited clear effects at 400 mg/kg/day. These effects on operant behavior were seen following the first dose and tolerance tended to develop. Thus, there was no evidence from these studies for a progressive neurotoxicity from trihalomethanes in adult mice. A behavioral teratology study was also conducted with TCM. Both parents were treated with 31.1 mg/kg/day TCM, and treatment of the dam continued throughout gestation and lactation. No clear evidence for behavioral effects in the offspring were observed. The most sensitive measure for the effects of TCM was the taste aversion paradigm in which saccharin aversions were produced after a single treatment of 30 mg/kg.
Syphilis
Authors: G. Marshall Crawford
Journal: New England Journal of Medicine (1950)

AS this survey is being prepared, it is now approaching seven years since the first announcement of the treatment of syphilis with penicillin. Seldom in the history of medicine has there been a new treatment for any disease that was universally so dramatically effective and at once accepted. Penicillin is thus far standing the test of time, although some years must yet elapse before its ultimate value will be determined. Numerous improvements have come about in methods of administration, but the optimal dosage schedules are yet to be worked out. Despite these great strides in the treatment of syphilis, a . . .
<i>Index of 1180 Postmortems of the Insane, State Hospital for the Insane, Norristown, Pa.</i>By H. J. Sommer, Jr., M. D., Pathologist; formerly Assistant Physician of the institution. With an introduction by Allen J. Smith, A. M., M. D., Professor of Pathology, University of Pennsylvania; Consulting Pathologist of the Hospital. (Published and distributed by authority of the Board of Trustees, 1908.)
Journal: American Journal of Psychiatry (1908)
Curable Dementia
Authors: WILLIAM H. BARKER
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 March 1983Curable DementiaWILLIAM H. BARKER, M.D.WILLIAM H. BARKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-411_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article on dementia in the elderly (1) brings to the attention of physicians the potentials for prevention or amelioration of this silent epidemic. However, the contributors have, in certain important respects, both overstated and understated the case.In the discussion of reversible dementia the authors repeatedly assert that 20% of patients with dementia may have reversible causes. The problem lies with the validity of this estimate as applied to dementia in the elderly. This figure was obtained by combining "data from four large series" that gave a total of 406 patients, 82 (20.2%) of whom were...References1. BECKBENSONSCHEIBELSPARRUBENSTEIN JDAJL. Dementia in the elderly: the silent epidemic. Ann Intern Med. 1983;98:231-41. Google Scholar2. WELLS C. Chronic brain disease: an overview. Am J Psychiatry. 1978;135:1-12. CrossrefMedlineGoogle Scholar3. SMITH J. The investigation of dementia: results in 200 consecutive admissions. Lancet. 1981;1:824-7. CrossrefMedlineGoogle Scholar4. . Senility reconsidered: treatment possibilities for mental impairment in the elderly. JAMA. 1980;244:259-63. CrossrefMedlineGoogle Scholar5. ELLENBERGNELSON JK. Sample selection and the natural history of disease: studies of febrile seizures. JAMA. 1980;243:1337-40. CrossrefMedlineGoogle Scholar6. PITT B. Psychogeriatrics. An Introduction to the Psychiatry of Old Age. Edinburgh: Churchill Livingstone; 1982:39-63. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM H. BARKER, M.D.Affiliations: University of Rochester School of Medicine Rochester, NY 14642 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1983Volume 98, Issue 3Page: 411-411KeywordsDementiaElderly ePublished: 1 December 2008 Issue Published: 1 March 1983 PDF downloadLoading ...
Premenstrual tension.
Authors: U Halbreich
Journal: BMJ (1979)

the bacteriological findings correlate well with those in that condition.The normal cell count in the CSF is rare in tuberculosis of the central nervous system but may occur.'-3We think that a positive culture for M tuberculosis might be a more common finding, were one to look for it, and that the possible tuberculous nature of meningitis should not be discarded because of benign presentation only.
Impairments of Memory and Learning in Older Adults Exposed to Polychlorinated Biphenyls via Consumption of Great Lakes Fish
Authors: Susan L. Schantz, Donna M. Gasior, Elena Polverejan, Robert J. McCaffrey, Anne M. Sweeney, Harold E. B. Humphrey, Joseph C. Gardiner
Journal: Environmental Health Perspectives (2001)

An association between in utero polychlorinated biphenyl (PCB) exposure and impaired childhood intellectual functioning has been reported, but the potential impact of PCB exposure during adulthood on intellectual functioning has received little attention. We assessed the impact of PCBs and other fish-borne contaminants on intellectual functioning in older adults. The subjects were 49- to 86-year-old Michigan residents recruited from an existing cohort. Fish eaters ate > 24 lb of sport-caught Lake Michigan fish per year and non-fish eaters ate < 6 lb of Lake Michigan fish per year. A battery of cognitive tests including tests of memory and learning, executive function, and visual-spatial function was administered to 180 subjects (101 fish eaters and 79 non-fish eaters). Blood samples were analyzed for PCBs and 10 other contaminants. We evaluated cognitive outcomes using multiple regression. PCBs and dichlorodiphenyl dichloroethene (DDE) were markedly elevated in fish eaters. After controlling for potential confounders PCB, but not DDE, exposure was associated with lower scores on several measures of memory and learning. These included the Weschler Memory Scale verbal delayed recall (p = 0.001), the semantic cluster ratio (p = 0.006), and list A, trial 1 (p = 0.037), from the California Verbal Learning Test. In contrast, executive and visual-spatial function were not impaired by exposure to either PCBs or DDE. In conclusion, PCB exposure during adulthood was associated with impairments in memory and learning, whereas executive and visual-spatial function were unaffected. These results are consistent with previous research showing an association between in utero PCB exposure and impairments of memory during infancy and childhood.
Operation of Platinum-Palladium Catalysts with Leaded Gasoline
Authors: D. Maxwell Teague, Leo. B. Clougherty, Anthony N. Speca
Journal: Environmental Health Perspectives (1975)

The effect of various fuel additives on the ability of platinum-palladium catalytic converters to remove the carbon monoxide and hydrocarbon components of automotive exhaust has been examined. Engine dynamometer studies suggest that these catalysts may be successfully used in conjunction with fuels of relatively high tetraethyllead concentrations, provided the ethylene dibromide portion of the scavenger is excluded.
Prognostic value of systemic inflammatory biomarkers in patients with mCRPC treated with Abiraterone in pre-docetaxel setting
Authors: R. Ratta, E. Verzoni, F. Pantano, P. Grassi, D. De Lisi, M. Prisciandaro, R. Montone, M. Sorrentino, F. de Braud, D. Santini, G. Procopio
Journal: Annals of Oncology (2017)
Characterization of Overt B-Cell Lymphomas in Patients With Hepatitis C Virus Infection
Authors: Salvatore De Vita, Cosimo Sacco, Domenico Sansonno, Annunziata Gloghini, Franco Dammacco, Marina Crovatto, Gianfranco Santini, Riccardo Dolcetti, Mauro Boiocchi, Antonino Carbone, Vittorina Zagonel
Journal: Blood (1997)
Preventing disease and promoting health
Authors: M. F. Goldsmith
Journal: JAMA (1990)

"THE VERY HEART of CDC" is what Jeffrey P. Koplan, MD, MPH, director of the Center for Chronic Disease Prevention and Health Promotion, calls his section, which began operation in 1988. "We consider the meat of public health in the 1990s, and for the foreseeable 50 years at least, to be the activities we are responsible for here," he says. Although such chronic diseases as heart disease, cancer, hypertension, stroke, asthma, diabetes, arthritis, and Alzheimer's disease are the cause of 70% of all deaths in the United States, Koplan says, "they seem boring to people and there's a lack of interest." So while his center tries to drum up excitement about preventing things people would rather not think about, it also promotes behaviors that will make people feel good and be healthy. The center concerns itself with all major health risks except alcohol and drug addiction and injury prevention. Anticigarette
Renal failure and perforating folliculitis
Authors: R. D. Hudson
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The greatest single automotive safety development to attenuate the carnage caravan of our highways is the three-point suspension, lap belt-shoulder harness. When properly used, it affords tremendous protection. A point of concern: I have noted a defect in the slack adjustment of the cross shoulder-chest strap in a large percentage of vehicles I have driven in the past two to three years. The harness locks are vehicleimpact actuated, and these devices apparently work well. But for the locked harness to be effective, it must be in close proximity to the chest. The slack reel was designed to allow people to move about and adjust instrument dials in greater comfort. If, when returning to the upright position, the slack in the shoulder strap is not automatically taken up, then this leaves approximately 13 to 20 cm of slack for forward travel of the torso. This can allow the