Gentamicin Dosage
Authors: DANIEL A. SPYKER
Journal: Annals of Internal Medicine (1977)

Comments and Corrections1 March 1977Gentamicin DosageDANIEL A. SPYKER, PH.D., M.D., RICHARD L. GUERRANT, M.D.DANIEL A. SPYKER, PH.D., M.D.Search for more papers by this author, RICHARD L. GUERRANT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-3-357 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Hull and Sarubbi recently reported a practical strategy for adjusting both the dose and interval in giving gentamicin and described their success in using this strategy clinically (Ann Intern Med85:183-189, 1976). However, use of the Siersbaek-Nielson nomogram (1) and the maintenance dose table in their Figure 4B as described could result in significant accumulation in large patients and underdosing in small patients. A 70-kg patient with a creatinine clearance (CCr) of 30 ml/min will be expected to have identical peak serum levels after each dose. The maintenance dose from their tables for a patient with a...References1. SIERSBAEK-NIELSONMOLHOLM-HANSENKAMPMANN KJJ: Rapid evaluation of creatinine clearance. Lancet 1:1133-1134, 1971 CrossrefGoogle Scholar2. DETTLISPRINGRYTER LPS: Multiple dose kinetics and drug dosage in patients with kidney disease. Acta Pharmacol Toxicol (Kbh) 27 (suppl 3) :211-224, 1971 Google Scholar3. WAGNER J: Fundamentals of Clinical Pharmacokinetics. Hamilton, Illinois, Drug Intelligence Publications, 1975. Google Scholar4. GAULTCOCKCROFT MD: Creatinine clearance and age. Lancet 2:612-613, 1975 CrossrefMedlineGoogle Scholar1. HULLSARUBBI JF: Gentamicin serum concentrations: pharmacokinetic predictions. Ann Intern Med 85:183-189, 1976 LinkGoogle Scholar2. CHANBENNERHOEPRICH REP: Gentamicin therapy in renal failure: a nomogram for dosage. Ann Intern Med 76:773-778, 1972 LinkGoogle Scholar3. MCHENRYGAVANGIFFORD MTR: Gentamicin dosages for renal insufficiency. Ann Intern Med 74:192-197, 1971 LinkGoogle Scholar4. KOCH-WESERSIDELFEDERMAN JVE: Adverse effects of sodium colistimethate. Ann Intern Med 72:857-868, 1970 LinkGoogle Scholar5. ORMECUTLER BR: The relationship between kanamycin pharmacokinetics: distribution and renal function. Clin Pharmacol Ther 10:543-550, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Virginia Hospital Charlottesville, VA 22901 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRemembering the PastCreatinine Clearance: Corrected versus UncorrectedMoxalactam and cefazolin: comparative pharmacokinetics in normal subjectsPharmacokinetics of moxalactam in subjects with various degrees of renal dysfunctionAmikacin Serum Concentrations: Prediction of Levels and Dosage GuidelinesFELIX A. SARUBBI Jr., M.D., J. HEYWARD HULL, M.S.Pharmacokinetics of Cefaclor and Cephalexin: Dosage Nomograms for Impaired Renal FunctionEstimation of Creatinine Clearance from Serum Creatinine Concentration — A ReviewPredicted Creatinine ClearanceTOBIAS L. YEH, PHARM.D., RAYMOND D. SILKAITIS, PH. D. 1 March 1977Volume 86, Issue 3Page: 357-358KeywordsCreatinine Issue Published: 1 March 1977 PDF downloadLoading ...