tbuckley/cabot-search huggingface dataset:
Contempo '91
Authors: J. W. Zylke
Journal: JAMA (1991)

Reflecting on the events and achievements of the year past is commonplace. Most corporations publish an annual report. News organizations compile a "year in review." And<i>JAMA</i>recaps the year in medicine with its Contempo issue. Each year we ask leaders from some of the many medical specialties and related fields to cite what they believe are the most important developments in their areas. The aim is to inform physicians about advances in medicine outside their fields. Thirty-eight articles constitute this year's issue. As always, because of space limitations, not all specialties can be included. Much has happened in world events since our last Contempo issue. Germany was reunified, and a multinational coalition waged war against Saddam Hussein. Nationally, attention ranged from the effects of the recession to the President's dislike of broccoli. Political freedom, the horrors of war, want in America, the presidential palate. A year of contrasts. So
Errata
Journal: BMJ (1843)

MISCELLANEOUS [NTELLIGENCE. way upwards between the crura, merely dissecting through cellular connections.Dr. Stokes concluded by remarking that there were three circumstances in this case which rendered it of great value :-First, the diagnosis of the aneurysm from symptoms; second, the confirmation of the stethoscopic signs; third, the peculiar mode of tennination, which, as he stated at the commencement, had not been previously described by any pathologist.-Dub.Journ.Med.Sci.ATROPHY OF THE UTERUS-AMENORRH(EA.Dr. Montgomery made some remarks on the functions and pathology of the uterus.He said that it had frequently been observed that the catamenia were absent in cases where there was organic diseases of the lungs, liver, or heart.He had found that in
Relation of Osteopenia to Glucocorticoid Replacement Therapy in Addison Disease
Authors: Mark H. Wener
Journal: Annals of Internal Medicine (1994)

Letters1 August 1994Relation of Osteopenia to Glucocorticoid Replacement Therapy in Addison DiseaseMark H. Wener, MDMark H. Wener, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-3-199408010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Zellisen and colleagues [1] concluded that a small difference in replacement glucocorticoid dose was probably responsible for the decreased bone mineral density (BMD) observed in 32% of men with treated Addison disease. The absolute glucocorticoid dose was not statistically higher in men with decreased compared with normal BMD (mean, 31.0 ± 6.3 mg/d compared with 28.4 ± 7.3 mg/d of hydrocortisone; P = 0.32); however, the weight-adjusted dose was reported to be significantly different (0.43 ± 0.08 mg/kg compared with 0.35 ± 0.10 mg/kd per day). Because the statistical difference between groups was marginal (P = 0.032) ...References1. Zellisen PM, Croughs RJ, Van Rijk PP, Raymakers JA. Effect of glucocorticoid replacement therapy on bone mineral density in patients with Addison disease. Ann Intern Med. 1994; 120:207-10. Google Scholar2. Edelstein SL, Barrett-Connor E. Relation between body size and bone mineral density in elderly men and women. Am J Epidemiol. 1993; 138:160-9. Google Scholar3. Felson DT, Shang Y, Hannan MT, Anderson JJ. Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res. 1993; 8:567-73. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1994Volume 121, Issue 3Page: 235-237KeywordsBody mass indexBody weightBone densityBone mineral densityGlucocorticoid therapyOsteopeniaRheumatoid arthritis ePublished: 15 August 2000 Issue Published: 1 August 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 3091: Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain In Outpatient Clinic By Adenosine Stress Magnetic Resonance
Authors: Wing Sze Chan, Ching Hon Luk, Hung Fat Tse
Journal: Circulation (2007)

Background: This study was designed to determine the diagnostic value of adenosine cardiac magnetic resonance (CMR) in low to moderate total number cardiac risk factor (TLCRF) patients presenting with chest pain in outpatient clinic. We hypothesized that adenosine CMR has a high negative predictive value in development of CAD or future adverse cardiac events. Methods: Adenosine stress CMR was performed on 315 pts who presented initially to outpatient clinics with chest pain. Ten patients confirmed to have previous myocardial infarction defined by delay CMR were excluded. Three patients were excluded due to suboptimal image quality. Patients were followed up during outpatient visits or contacted through telephone interview to determine the incidence of significant CAD defined as coronary artery stenosis &gt;50% on angiography, new myocardial infarction (MI), or cardiovascular death. Results: Totally 302 patients (M: F = 242:60; mean age= 58±12; mean baseline TLCRF= 2.5 ± 1) underwent rest and adenosine stress CMR. With a follow up period of 29 ± 6 months, there were 32 adverse event (30 patients underwent coronary percutaneous angioplasty due to unstable angina and 2 new MI) and 3 cardiovascular deaths. Adenosine perfusion abnormalities had 100% sensitivity and 89% specificity in detecting subsequent CAD and the most accurate component of the CMR examination in predicting events. Despite TLCRF and abnormal CMR can significantly predicting the prognostic outcome (p=0.04 Vs p=0.001 respectively), multivariate analysis showed that the abnormal CMR was the strongest predictor of the event rate (adjusted hazard ratio 1.45 per 10% increase, p=0.02). Three patients with normal adenosine study had a subsequent diagnosis of CAD and underwent successful angioplasty. Conclusions: Among the low to moderate cardiac risk patients who presented with chest pain in outpatient clinics, adenosine CMR examination has a high sensitivity and specificity in predicting the future development of significant CAD. It implies the potential application of CMR in CAD screening in general population.
Natural Hepatotoxins
Authors: A. Coady
Journal: BMJ (1965)

Natural Hepatotoxins SIR,-The juxtaposition of your recent leading article (15 May, p. 1261) on natural hepatotoxins with that on communication difficulties inherent in the increasing proliferation of specialist journals (" Too Many Words," p. 1264) was timely.For the ques- tion, " Are these toxins in any part responsible for the chronic liver disease which is so wide-
T-Cell/Histiocyte–Rich Large B-Cell Lymphoma: A Distinct Clinicopathologic Entity
Authors: R. Achten, G. Verhoef, L. Vanuytsel, C. De Wolf-Peeters
Journal: Journal of Clinical Oncology (2002)

Although it has proven difficult to delineate diagnostically reproducible and clinically relevant subgroups, the heterogeneity of diffuse large B-cell lymphomas (DLBCL) is widely acknowledged. In 1992, we reported on six cases that suggested that large B-cell lymphoma rich in stromal histiocytes and T cells may be identified as a distinct clinicopathologic entity within DLBCL.An integrated clinicopathologic study of 40 cases of this DLBCL subtype is presented.Distinguishing a DLBCL rich in histiocytes and reactive T cells, designated T-cell/histiocyte--rich large B-cell lymphoma (THR-BCL), may be justified from a clinical point of view. The disease typically affects middle-aged male patients who usually present with advanced-stage disease that is not adequately managed with current therapeutic strategies. Whereas proliferation fraction and p53 overexpression, in addition to the clinical variables incorporated in the International Prognostic Index (IPI), significantly correlate with response to treatment and survival in a univariate analysis, only the IPI score identifies relevant prognostic THR-BCL subpopulations in a multivariate model. The morphologic and immunophenotypic profile of the neoplastic B cells in THR-BCL suggests that they may originate from a germinal center ancestor.THR-BCL constitutes a distinct clinicopathologic entity that is characterized by an aggressive behavior. Experimental therapeutic strategies may be indicated to obtain a more favorable response to treatment in this disease.
Screening in Health Fairs
Authors: Donald M. Berwick
Journal: JAMA (1985)

Health fairs provide multiphasic screening to more than 2 million Americans each year, and the number is growing rapidly. Nearly 40 different tests are in use, commonly including the measurement of up to 30 different blood chemistry levels. This report reviews the activities in a sample of 940 health fair sites and examines the experience regarding six specific screening procedures (blood pressure, anemia, blood chemistries, glaucoma, hearing, and fecal occult blood testing). Widespread use of these and other tests raises complex issues of cost, risk, and benefit. Rates of false alarm of healthy people and false reassurance of those at risk may be high for some tests, and the benefits of detecting new disease are easily overestimated. Detailed data collection and evaluation could help health fair sponsors to identify more rational screening strategies. (<i>JAMA</i>1985;254:1492-1498)
Correction
Journal: BMJ (1960)

MEDICAL JOURNAL____ of natural bristle.The hairdresser has disposed of all bristle brushes, and has had no trouble, so far as I know, since.It seems that hairdressers are more vulnerable than they used to be to this nuisance.Girls who are well paid and well dressed and who have a "hair-do" at the best local salon may well come from homes where several younger brothers and sisters are heavily infested with head-lice.I would like to thank Dr. J. B. Kershaw (Medical Officer of Health to the Hinckley U.D.C.) for his advice.We both felt that hairdressers might be glad to know of this problem.We also felt that not much seemed to be known of the practical techniques in keeping brushes and combs clean when in busy use.Has any- one, for instance, any authoritative advice about the efficacy of the little sterilizing cabinet which one sees
Special Article
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL CONFLICTS
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of obesity
Authors: D. R. Brightwell
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The recent report by Currey et al (237:2829-2831, 1977) on the behavioral treatment of obesity has several shortcomings of which the reader should be aware when making any judgments about it. First, the selection of the three articles presented in tabular form are hardly representative of the nearly 100 research reports published to date. Those presented represent neither the best nor the worst results obtained, nor are the sample sizes particularly representative. The types of treatments used in the three are so different that comparisons are not meaningful. While the selection of papers for review is the prerogative of the author, serious inaccuracies in the discussion of them are unacceptable. When totaling the eight papers reviewed by Stunkard and McLaren-Hume,<sup>1</sup>they apparently omitted completely the data from one of the studies,<sup>2</sup>which reflected some of the best results. The results of Penick et al<sup>3</sup>
Editorial Board
Authors: George Bartley, Henry Jampel, Daniel Albert, Andrew Schachat, Anita Agarwal, T Iqbal, Ike Ahmed, Jayakrishna Ambati, Tin Aung, Singapore Bengtsson, James Brandt, Wiley Chambers, Balwantray Chauhan, Emily Chew, Michael Chiang, Helen Danesh-Meyer, Marjan Farid, Steven Gedde, Lynn Gordon, Los Angeles, Mingguang He, Bennie Jeng, Tianjing Li, Sue Lightman
Journal: Ophthalmology (2016)
United States-Japan Cooperative Drug an Abuse Study
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peter Richards
Authors: C. McManus
Journal: BMJ (2012)

Notch is a cell surface receptor that is known to regulate developmental processes by establishing physical contact between neighboring cells. Many recent studies show that it also plays an important role in the formation of long-term memory (LTM) in adults, implying that memory formation requires regulation at the level of cell–cell contacts among brain cells. Neither the target of Notch activity in LTM formation nor the underlying mechanism of regulation is known. We report here results of our studies in adult <i>Drosophila melanogaster</i> showing that Notch regulates dCrebB-17A, the CREB protein. CREB is a transcriptional factor that is pivotal for intrinsic and synaptic plasticity involved in LTM formation. Notch in conjunction with PKC activity upregulates the level of a hyperphosphorylated form of CREB (hyper-PO4 CREB) and triggers its ultradian oscillation, both of which are linked to LTM formation. One of the sites that is phosphorylated in hyper-PO4 CREB is serine 231, which is the functional equivalent of mammalian CREB serine 133, the phosphorylation of which is an important regulator of CREB functions. Our data suggest the model that Notch and PKC activities generate a cyclical accumulation of cytoplasmic hyper-PO4 CREB that is a precursor for generating the nuclear CREB isoforms. Cyclical accumulation of CREB might be important for repetitive aspects of LTM formation, such as memory consolidation. Because Notch, PKC, and CREB have been implicated in many neurodegenerative diseases (e.g., Alzheimer9s disease), our data might also shed some light on memory loss and dementia.
Optimal Criteria for End-Stage Kidney Disease Care
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-022 Factors Affecting Response to Low Fodmaps Therapy in the Management of Irritable Bowel Syndrome; Fructose and Lactose Breath Testing, IBS Subtype and Symptom Severity
Authors: A Cox, J Eady, K Keetarut, N Zarate-Lopez, E Feurtado, R Rutherford, A Emmanuel
Journal: Gut (2016)

<h3>Introduction</h3> A low FODMAPs diet is an effective dietary intervention for the management of irritable bowel syndrome (IBS). We hypothesised that hydrogen breath testing (HBT) for lactose and fructose intolerance would identify potential responders. Secondly we hypothesised that greater improvement would be seen in diarrhoea predominant (IBS-D) than other subtypes. <h3>Methods</h3> 167 consecutive patients with a Rome III IBS diagnosis who completed low FODMAPs dietary education therapy were analysed. Symptoms were assessed at baseline and follow up (median 63 days post-treatment) via self-administered questionnaire. The primary endpoint was a symptom severity score (scale 0–5) based on pain, bloating, constipation and diarrhoea. According to clinician choice, some patients underwent HBT with fructose 30 gm (n = 74) and lactose 30 gm (n = 103). <h3>Results</h3> Subtypes were IBS-D (n = 91, 67 f, mean age 42), IBS-C (n = 41, 35 f, mean age 45) and IBS-M (n = 34, 29 f, mean age 36). Across all patients, an improvement in symptom severity (2.4 to 1.6, p &lt; 0.001) was observed following low FODMAPs diet. Patients with a positive fructose BT (26/74, 35%) experienced statistically greater improvement in symptom severity (2.7 to 1.5, p &lt; 0.01), but not those with positive lactose BT (36/102, 35%). Compared to IBS-D (2.4 to 1.5) and IBS-C (2.4 to 1.6), a greater response was seen in IBS-M (3.1 to 1.9, p &lt; 0.01). Response was correlated to baseline symptom severity (r = 0.45, p &lt; 0.001). <h3>Conclusion</h3> A low FODMAP diet may particularly beneficial in patients with fructose malabsorption. Severity of symptoms at baseline may predict degree of improvement which may explain the greater response seen in IBS-M patients in this study. A low FODMAP diet may particularly beneficial in patients with fructose malabsorption. Severity of symptoms at baseline may predict degree of improvement which may explain the greater response seen in IBS-M patients in this study. <h3>Disclosure of Interest</h3> None Declared
A strategy for cost containment in coronary surgery
Authors: F. D. Loop
Journal: JAMA (1983)

Patients with multivessel coronary atherosclerosis and stable angina pectoris were examined by outpatient testing and admitted to a staging area with their families on the morning of coronary bypass surgery. This experimental group was not hospitalized before surgery. Their hospital charges were compared with those of cohorts of coronary artery surgery patients from 1977 to 1981 who met the same entrance criteria. Length of stay in the hospital was reduced by two days. A 10% savings in hospital charges was realized in the 1981 experimental group as compared with the 1981 control group. A comparison of total hospital charges, adjusted for inflation, shows that 1981 experimental group patients paid 35% less for their hospital room, 45% less for their intensive care period, and 17% less in total charges than the 1977 control group. Interviews indicated that these patients with stable cardiac conditions preferred to stay with their families or friends before surgery. (<i>JAMA</i>1983;250:63-66)
Pediatrics and Adolescent Medicine
Authors: Jeanne M. Santoli
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal