tbuckley/cabot-search huggingface dataset:
The Stick
Authors: V.J. Kopp
Journal: Annals of Internal Medicine (1997)

Ad Libitum1 December 1997The StickV.J. Kopp, MDV.J. Kopp, MDUniversity of North Carolina at Chapel Hill; Chapel Hill, NC 27599-7010Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-11-199712010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In Donne's flea, lovers' bloods mixed,While ours was ill-met inside a needle:Not at all humorous, the point slippingFrom your vein into mine, drawingWhat was drawn from you into me,A flash between our tingling arms.Now we are both tested and testing,Closer than lovers, no less trusting;A new type of kin, I suppose, boundTogether, our lives newly mingled,Each changing each, changed forever,A brave new chimera, by chance created. Author, Article, and Disclosure InformationAffiliations: University of North Carolina at Chapel Hill; Chapel Hill, NC 27599-7010Corresponding Author: V.J. Kopp, MD, 501 East Rosemary Street, Chapel Hill, NC 27514. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1997Volume 127, Issue 11Page: 1028KeywordsBloodFleasVeins ePublished: 15 August 2000 Issue Published: 1 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cadmium-Binding Proteins in Pseudomonas putida: Pseudothioneins
Authors: Denise P. Higham, Peter J. Sadler, Michael D. Scawen
Journal: Environmental Health Perspectives (1986)

Pseudomonas putida adapted to growth in 3 mM cadmium.The resistance mechanism involved complexation of cadmium in polyphosphate granules, changes in the structure of the cell membrane and induction of three cysteine-rich, low molecular weight proteins (3500-7000) containing 4 to 7 g-atoms per mole of cadmium, zinc, and copper.Each protein was produced during a different phase of growth, and the smallest protein (3500) was released into the environment when the cells lysed at the end of the exponential phase.The metal binding sites of the major protein were further characterized using a range of physical methods, including 118Cd NMR.The properties of the bacterial pseudothioneins are compared to those of metallothi- oneins.
Abnormal Psychology: Its Concepts and Theories.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypofractionated radiotherapy versus conventional fractionated radiotherapy in elderly patients with glioblastoma multiforme
Authors: H. M. El-Shenshawy, A. Abd El-Razek, H. Bader
Journal: Journal of Clinical Oncology (2007)

2042 Background: To evaluate efficacy of short- course radiotherapy(RT) in elderly (&gt;60 years) patients with glioblastoma multiforme (GBM), and compare this biological similar short -course radiotherapy with a standard radiotherapy. Methods: Forty-four elderly patients with GBM were randomly assigned after surgery to receive either a short-course of radiotherapy (45 Gy in 15 fractions over 3 weeks) or standard radiotherapy (60 Gy in 30 fractions over 6 weeks) to a target volume described as tumor visible on CT scan and a 2 cm margin. The primary end point was overall survival. Results: The overall response rate and median duration of response were 60% and 8.5 months in short-course RT versus 65% and 8 months in standard RT. Improvement in pretreatment performance status and increase in post-treatment corticosteroid dosage were observed in 50% and 25% in short-course RT versus 40% and 50% in standard RT (P=0.09, P=0.031) respectively. Median survival time was 5.9 months in short-course RT versus 5.6 months in standard RT. Six months, 1-year survival and progression-free survival rates were 40%, 15% and 30% ,10% in short-course RT versus 45%, 10% and 35%, 5% in standard RT, respectively. In both treatment groups, females did significantly better than males, patients with KPS 60–70 did significantly better than those with KPS 50, patients having tumors 4–5 cm did significantly better than those with tumors 6–8 cm as well as did those with more radical surgery when compared to those with biopsy only. On multivariate analysis, only tumor size and extent of surgery were found to independently influence survival. Acute toxicity was generally assessed as mild in the two treatment groups. While RT-induced brain necrosis appeared only in one patient received short- course RT, but this patient died from tumor recurrence. Conclusions: Hypofractionated RT is feasible and safe treatment for elderly patients with GBM. No significant financial relationships to disclose.
ARTIFICIAL SUSCEPTIBILITY TOWARD THE BACILLUS OF SOFT CHANCRE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
5. Oral carbenicillin
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated beta 2‐microglobulin in lymphorrhea from immunoblastic lymphoma
Authors: Lev Shvidel, Eljakim Vorst, Alain Berrebi
Journal: American Journal of Hematology (1998)

The letter published in the November 1997 issue, regarding simultaneous occurrence of lupus anticoagulant (LA) and factor VIII inhibitors [1,2], is very interesting.We agree with Dr. D.A. Triplett that it is of critical importance to differentiate an LA from a factor VIII inhibitor.Strict observance of the criteria recommended by the SSC Subcommittee on Lupus Anticoagulant/Phospholipid-Dependent Antibodies [3] is essential for this purpose.More than one test, with different assay principles, is necessary to screen for an LA, mainly in patients with other simultaneous coagulation defects, such as a neutralizing inhibitor or a factor deficiency.In a recently published study of 170 consecutive hemophilia A patients, we found 36 hemophiliacs who fulfilled the criteria for the diagnosis of LA, 18 of them with a time-dependent effect.It is possible that subjects with a strong time-dependent effect may have both a factor VIII inhibitor and an LA (n ‫ס‬ 12) [4].LAs were diagnosed based mainly on diluted Russell viper venom time (dRVVT).The activated partial thromboplastin time (APTT) is affected by factor VIII inhibitors; however, the platelet neutralization procedure of the APTT showed similar results to those obtained for dRVVT, except in three patients with positive dRVVT, for whom the shortening of the PNP was not sufficient to be considered positive.In our study, the StaclotLA results agreed with those from dRVVT; 8/8 were positive on LAs and 3/3 were negative on factor VIII inhibitors.We believe that factor VIII inhibitors could be masked by LA and the misdiagnosis could delay the prescription of the appropriate therapy [5].The above evidence stresses the need to develop a specific test to identify factor VIII inhibitors without interference of LA, and vice versa.
Henry Marshall, M.D., F.R.C.S.Edin., F.R.S.E
Journal: BMJ (1898)

sexual craving is not stronger than the alcoholic among savages and in many of us, but for how long has our moral system fulminated against illicit sexual intercourse, and with what results ?Dr. Coates pins his faith to repressive measures and dilute solutions of alcohol.Is he aware that we have evidence of constant repressive measures since the time of the Ancient Egyptians, and in England since the sixth century.I fear I am becoming a little weary of point- ing out that savages, who have used dilute solutions from time immemorial, when they have the opportunity, are among thejmostlintemperate races on earth.-Iam, etc., ,Southsea, April'5th.G. ARCHDALL REID, M.B.VEGETARIANISM AND INDIAN EXPERIENCE.SIR,-I desire to refer very briefly
Current Concepts in Cancer— No. 29
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2085: Treatment of human melanoma cells with dasatinib requires inactivation of both mTOR and MAPK pathways to achieve high cell eradication efficacy
Authors: Jiri Vachtenheim, Jiri Réda, Kateřina Vlčková, Lubica Ondrušová
Journal: Cancer Research (2019)

Abstract Advanced stages of melanoma are resilient to therapy and new strategies for the treatment are required. About 60% of melanomas harbor the mutated BRAF oncogene, which activate the MAPK pathway. This BRAF driver mutation can be targeted by a small molecule drug vemurafenib. However, most of patients develop resistance during treatment and even drug addiction is acquired. The nonreceptor SRC tyrosine kinase is highly expressed and deregulated in melanoma and can be efficiently inhibited by the inhibitor dasatinib, an anticancer drug which is already used for the treatment of some tumor types. SRC does not have its own canonical pathway but is capable of activating and augmenting different signaling routes in cancer cells. We found that melanoma tumor cell lines analysed were generally resistant to dasatinib irrespective of BRAF or NRAS mutational status. The exception was the cell line Hbl which was very sensitive even to low dasatinib doses and Hbl cells were completely eradicated by 10 nM of dasatinib in several days. The sensitivity of Hbl to dasatinib was dependent on the drug ability to inhibit completely both the MAPK and AKT/mTOR signaling pathways. Dasatinib was capable of inhibiting SRC activation resulting in the repression of AKT activation in Hbl cells. AKT phosphorylation at Ser473 was fully abolished and Thr308 was severely attenuated through inhibiting SRC by dasatinib in Hbl cells. These two phosphorylations are required for AKT activity. MAPK pathway (ERK1/2 phosphorylation) was also inhibited in Hbl cells. Dasatinib also inhibited the phosphorylation of SRC at Tyr416 (a hallmark of SRC activity) in Hbl cells and, surprisingly, also in other dasatinib-resistant melanoma cells. Importantly, although SRC was dephosphorylated at Tyr416, dasatinib was unable to inactivate AKT and MAPK pathway (ERK1/2) in all other melanoma cells. Molecular changes closely correlated with proliferation assays. Our data indicate that the combination therapy of melanoma with dasatinib would bring benefit to patients only by blocking both MAPK and AKT signaling pathways in melanoma cells. Altogether, more molecular knowledge of the effects of the powerful anticancer drug dasatinib is required in order to be used for the treatment of melanoma. This work was supported by the Institutional research project PROGRESQ25 from Charles University Prague. Citation Format: Jiri Vachtenheim, Jiri Réda, Kateřina Vlčková, Lubica Ondrušová. Treatment of human melanoma cells with dasatinib requires inactivation of both mTOR and MAPK pathways to achieve high cell eradication efficacy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2085.
ANESTHESIOLOGY
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stalkers of Pestilence: The Story of Man's Ideas of Infection.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2503: The Influende of Renal Function on Clinical Outcome and Response to Beta-Blockade in Systolic Heart Failure: Insights from MERIT-HF
Authors: Jalal Ghali, John Wikstrand, Dirk V Veldhuisen, Bjorn Fagerberg, Sidney Goldstein, Ake Hjalmarson, Peter Johansson, John Kjekshus, Michael Klibaner, Lis Ohlsson, Ola Samuelsson, Finn Waagstein, Hans Wedel
Journal: Circulation (2007)

Objective: We analyzed the data from MERIT-HF in order to determine the impact of renal function on absolute risk for and type of clinical events, and to study any interaction between renal function and the risk reducing effect and tolerability of metoprolol CR/XL in systolic HF Methods: Glomerular filtration rate was estimated using the simplified MDRD formula (eGFR MDRD ). Patients were divided in four subgroups according to defined cut off points for renal dysfunction: Normal renal function: eGFR MDRD ≥ 90 (n = 411); mild renal failure ≥ 60 &lt; 90 (n = 2085); moderate renal failure ≥30 &lt; 60 (n = 1387); and severe renal failure &lt; 30 ml/min/1.73m 2 BSA (n = 82). Results : Table shows one year risk per patient year of follow-up (placebo). Risk reduction with metoprolol CR/XL was consistent regardless of renal function Metoprolol CR/XL was well tolerated in renal failure. Conclusion: The risk for death and hospitalizations from worsening HF increased steeply with a decrease in renal function. The beneficial effect of metoprolol CR/XL on outcomes was maintained regardless of renal function. Metoprolol CR/XL was well tolerated in renal failure.
Manuscripts Approved for JNCI, May-June 1972
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Manuscripts Approved for JNCI, May-June 1972 Get access JNCI: Journal of the National Cancer Institute, Volume 49, Issue 1, July 1972, Pages 318–320, https://doi.org/10.1093/jnci/49.1.318-b Published: 01 July 1972
The Rh-sensitized pregnant woman
Authors: H. Schulman
Journal: JAMA (1966)

Spectrophotometric analysis of amniotic fluid in Rhsensitized pregnant women has produced a dramatic change in the management of these patients while improving the outlook for the fetus.<sup>1</sup>This test represents a significant addition to medical horizons because it offers a biochemical quantitation of fetal substances as the basis for venturing into intrauterine fetal therapy. This report represents a consolidation of two experiences in two separate centers and identifies diagnostic features which are the basis of current management. <h3>Amniotic-Fluid Test.—</h3> In a previous report the spectrophotometric analysis of amniotic fluid was described and the available information relating to the test was summarized.<sup>2</sup>During the past year there have been many additional reports confirming the value of this procedure.<sup>1,3-6</sup>One of the unfortunate developments in reporting the data is the lack of uniformity.<sup>1-3</sup>We have tried to analyze the basis for the diverse kinds of data-reporting different from
Book Reviews
Authors: Lawrence Friedman
Journal: Hepatology (1996)

HEPATOLOGY welcomes books for review and invites its view of the duodenal lesions of Mycobacterium avium complex also includes corresponding frames of the abdominal readers both to identify books of hepatological interest and computed tomography scan, photomicrographs of the histolto serve as book reviewers.Books of note should be called to ogy obtained at endoscopic biopsy, and gross photographs of the attention of the Book Editor, and potential reviewers the autopsy specimen with appropriate text.should indicate their areas of interest.The Book Editor none-The sections on the esophagus, stomach, and duodenum are theless reserves the right to select appropriate reviews for very strong and up-to-date.The views of the hypopharynx are publication on these pages.excellent, as are the varied examples of esophageal and gastric disorders.These sections provide excellent clinical correlation as well as informative text.Likewise, the section on the colon Atlas of Clinical Gastrointestinal Endoscopy: Companis quite strong.Unfortunately, for persons with an interest in ion to Sleisenger and Fordtran's Gastrointestinal hepatobiliary diseases, the section on endoscopic retrograde Disease.By C. Mel Wilcox.316 pp.Philadelphia: Sauncholangiopancreatography (ERCP) is not sufficiently detailed ders, 1995.$125.at this time to contribute significantly to the text.Other highquality atlases are available that cover this material.Overall, this clinical atlas provides very high-quality pic-This atlas is organized into seven anatomic sections and tures and up-to-date endoscopic photographs with valuable includes the hypopharynx, esophagus, stomach, duodenum, supporting material.With the exception of ERCP, this volsmall bowel, colon, anus-rectum, and periampullary region.ume is highly recommended for use both as a teaching re-Selected abnormalities are illustrated with high-quality source and as a desk reference.video images.In many examples, additional visual material expands and details the endoscopic image.When suitable,