tbuckley/cabot-search huggingface dataset:
SKI INJURIES IN ANCHORAGE
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Body composition
Authors: R. F. Jewkes
Journal: Clinical Nuclear Medicine (1991)

Radionuclide studies have made a major contribution to our understanding of the changes that the body undergoes in health and disease. Moore et al. (1963) used them to develop their concept of the body being made up of a number of distinguishable physiological compartments. First, the body cell mass, the 'engine', which comprises all the cells of the body, characteristically oxygen consuming and energy exchanging. Second, the extracellular tissues, the 'chassis', with a predominantly supporting role and characteristically very low metabolic activity. Third, the body fat, neutral triglyceride. Much of the extracellular compartment is fluid and includes the blood plasma, the interstitial fluid, cerebrospinal fluid, localized effusions and digestive juices.
DISCUSSION ON PAPER OF DR. HENRY BEATES, "THE USE OF DIGITALIN WITH REFERENCE TO DOSE."
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasonic catheters give cardiologists boost in observing internal blood vessels
Authors: M. F. Goldsmith
Journal: JAMA (1990)

MINIATURE ultrasonic probes are showing cardiologists more about coronary and peripheral vasculature than ever before. The new devices, developed separately during the last several years by four northern California-based companies, combine a catheter with an ultrasound transducer that is based on a wafer-thin chip to produce ultrasharp cross-sectional images. The resulting views of arterial narrowing delineate fibrous plaque as well as soft fatty plaque much better than such earlier techniques as contrast angiography or computed resonance imaging, say investigators. The new technique also provides an image of the arterial wall and enables measurement of the mass of the atheroma—both beyond the capability of angiography, they point out. The companies at work on this new device are Diasonics, which is located in Milpitas, working in conjunction with Boston Scientific; Endosonics, in Pleasanton; Cardiovascular Imaging Systems, in Sunnyvale; and InterTherapy, in Costa Mesa. The electronic innovation necessary to create these new devices
Book Review Safely Through Childbirth . A guide book for the expectant mother. A. J. Rongy. 192 pp. New York: Emerson Books, Inc., 1937. $2.00. Childbirth: Yesterday and Today. The story of childbirth through the ages to the present . A. J. Rongy. 192 pp. New York: Emerson Books, Inc., 1937. $2.00.
Journal: New England Journal of Medicine (1937)
Quantitative Predictivity of Carcinogenicity of the Autoradiographic Repair Test (Primary Hepatocyte Cultures) for a Group of 80 Chemicals Belonging to Different Chemical Classes
Authors: Claudia Bolognesi, Maurizio Taningher, Silvio Parodi, Leonardo Santi
Journal: Environmental Health Perspectives (1986)

In this work we have investigated the correlation existing between a short-term genotoxicity test (DNA repair in rat liver cells) and carcinogenicity in rodents. The work is in the framework of a line of thinking that considers as a possibility the utilization of the quantitative component of the information obtained from genotoxicity tests. In a preliminary report for 25 compounds belonging to different chemical classes, a correlation coefficient of 0.36 was found between carcinogenic potency in small rodents and potency in autoradiographic repair. This level of correlation is comparable with similar levels found for many other short-term tests: Ames test, alkaline DNA fragmentation in vivo, DNA adducts in vivo, morphological transformation in vitro and SCE induction in vivo. Obviously, since only 25 compounds were examined, assessment was rather uncertain, and the subdivision of the set into subsets for different chemical classes would have generated groups too small for a meaningful statistical analysis. With a much larger set (80 compounds) we hoped to be able to discriminate different predictivities for different chemical classes. This seems important because the test could be much more suitable for one given class than for another. Previous investigations with different short-term tests have shown that these differences can indeed exist and be very great. In this respect it is potentially very encouraging that the test considered here showed a fair correlation with carcinogenic potency for aromatic amines. Many other tests that we have examined so far have shown little or no predictivity for this important class of chemicals.
560P A next-generation sequencing analysis indicates genomic alterations in pathological morphologies: A genomic case report of pulmonary carcinosarcoma harbouring EGFR mutation
Authors: H. Koba, H. Kimura, Y. Amino, N. Terada, H. Matsuoka, S. Nishikawa, T. Yoneda, Y. Tambo, T. Sone, K. Kasahara
Journal: Annals of Oncology (2016)
Modulation of Eicosanoid Production by Human Alveolar Macrophages Exposed to Silica in Vitro
Authors: Hillel S. Koren, Marianne Joyce, Robert B. Devlin, Susanne Becker, Kevin Driscoll, Michael C. Madden
Journal: Environmental Health Perspectives (1992)

Repeated inhalation of silica dust can lead to inflammation and fibrosis in human lung and in experimental animal models. The alveolar macrophage is believed to play a pivotal role in this process. Numerous macrophage-derived growth factors, cytokines, and arachidonic acid metabolites have been shown to contribute to inflammation and fibrosis. The objective of this study was to determine the eicosanoid production by human alveolar macrophages in response to silica exposure in vitro and to assess the contribution of alveolar macrophages to silica-induced fibrosis and inflammation. Macrophages were obtained from healthy volunteers and were incubated for 3 or 24 hr in the presence of silica (100, 60, and 0 micrograms/mL). Supernatants were removed for eicosanoid analysis. Eicosanoids were analyzed by both high performance liquid chromatography and radioimmunoassay. The data suggest that silica causes an increased release of leukotriene B4, leukotrienes C4/D4/E4, and 5-hydroxyeicosatetraenoic acid (5-HETE) after 3 hr and decreases in prostaglandin E2 and thromboxane B2 production after 24 hr of exposure to 100 micrograms/mL silica. In addition, 12-HETE and 15-HETE production remained unchanged at either time point. These opposing effects seen with the metabolites of lipoxygenase and cyclooxygenase pathways could contribute to silica-induced fibrosis. The pattern of eicosanoid production after exposure to silica was different from that obtained when macrophages were stimulated with lipopolysaccharide for 3 or 24 hr, indicating that the response to the particles was not just due to general cellular activation.
Medical Care in the 1960's
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Public Health Law
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Continuing Challenge of Hemoglobin and Bile Pigment Metabolisms.
Authors: Cecil J. Watson
Journal: Annals of Internal Medicine (1965)

s1 May 1965The Continuing Challenge of Hemoglobin and Bile Pigment Metabolisms.Cecil J. Watson, M.D.Cecil J. Watson, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1083_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe discussion will focus mainly upon deficit and surplus of measurable bile pigment of the bile or excreta in relation to the amount anticipated from destruction of mature circulating erythrocytes. These are invariably present in some degree, even in the normal state, but are of great significance in hematologic diseases associated with dyserythropoiesis. Principal attention will be given to the phenomenon of "early labeling" of bile pigment and its heterogenetic character. The ratio:varies quite consistently as between normal erythropoiesis and that in various dyserythropoietic states. Considerable attention will be given to the possible factors responsible for low ratios, including... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1083-1083KeywordsBileErythropoiesisHemoglobin Issue Published: 1 May 1965 PDF DownloadLoading ...
In Vivo and in Vitro Exposure to PCB 153 Reduces Long-Term Potentiation
Authors: Rifat J. Hussain, Janos Gyori, Anthony P. DeCaprio, David O. Carpenter
Journal: Environmental Health Perspectives (2000)

We examined the effects of gestational and lactational exposure to polychlorinated biphenyl (PCB) 153 (2,4,5,2',4',5'-hexaCB) on the magnitude of long-term potentiation (LTP) observed in the CA1 region of hippocampal brain slices prepared from rats at 30 days of age. We compared these actions to those observed when PCB 153 is dissolved in normal Krebs-Ringer solution and perfused on slices from control rats of the same age. In vivo exposure was at three dose levels (1. 25, 5, and 20 mg/kg/day) from gestational day 3 through weaning at postnatal day 21. Although responses to low-frequency stimulation of the Schaffer collateral pathway in exposed animals were not different from controls, significantly reduced LTP was induced after tetanic stimulation, even at the lowest dose studied. We observed a comparable depression of LTP when control slices were perfused with Krebs-Ringer that had been equilibrated with PCB 153 in a generator column. Neither in vivo nor in vitro exposure significantly altered the input-output curves obtained before tetanic stimulation, but both suppressed the increase in response observed in controls after tetanic stimulation. Because LTP is thought to be correlated with learning ability, these observations may provide at least a partial mechanism to explain the reduction of intelligence quotient observed in humans exposed to PCBs early in development.
Treatment of Persons Exposed to Rabies-Reply
Authors: Michael A. W. Hattwick
Journal: JAMA (1976)

<h3>In Reply.—</h3> We agree that it is important to have a veterinarian's expert evaluation of the possibility of rabies being present in an animal that may have exposed a person to rabies. Certainly, the veterinarian's evaluation is one of the most important factors the physician should consider in deciding whether to start postexposure rabies prophylaxis. The second question raised in this letter is whether or not an unvaccinated dog that may have exposed a person to rabies should be sacrificed. As we stated before, we recommend that dogs involved in human exposures should be sacrificed and examined for rabies unless they are normally behaving and vaccinated. This is our opinion and recommendation, but we respect the alternative point of view presented by Dr Rosefsky and Mssrs Dunstan and Huse. We heartily concur, as will anyone who has worked with rabies, that close cooperation between physicians and veterinarians is crucial to
Survival experience among patients with AIDS receiving zidovudine. Follow-up of patients in a compassionate plea program
Authors: T. Creagh-Kirk
Journal: JAMA (1988)

Through a compassionate plea program (Treatment Investigational New Drug), 4805 patients with acquired immunodeficiency syndrome who previously had experienced<i>Pneumocystis carinii</i>pneumonia (PCP) received zidovudine (Retrovir, formerly azidothymidine). Overall survival at 44 weeks after initiation of therapy was 73% ( ± 2.1%). A positive association was found between survival and pretherapy clinical status as defined by hemoglobin level, functional ability, and stage of disease as measured by time since diagnosis of PCP. For patients with baseline hemoglobin levels of 120 g/L or greater, Karnofsky scores of 90 or greater, and PCP diagnosis within 90 days prior to initiation of therapy, 44-week survival was 88%. Adverse clinical experiences associated with zidovudine therapy were consistent with those from a double-blind, placebo-controlled trial. Survival experience of this large and diverse cohort is consistent with, and extends data from, this clinical trial. Comparison with available natural history data suggests that zidovudine therapy is associated with increased 44-week survival of post-PCP patients with acquired immunodeficiency syndrome. (<i>JAMA</i>1988;260:3009-3015)
Book Reviews
Journal: Allergy (1984)

Book reviewed in this article: de weck al Bundgaard, H (eds) : allergic reactions to drugs Riethmüller, G., Koprowski, H., von Kleist, S. &amp; Munk, K. : Genes and antigens in cancer ceils – The monoclonal antibody approach Alman, L. C. (ed.): Clinical allergy &amp; immunology Andreani, D., Di Mario, U., Federlin, K. F. &amp; Heding, L. G. (eds.) : Immunology in diabetes
Therapy for Legionnaires Disease
Authors: Paul H. Edelstein
Journal: Annals of Internal Medicine (1999)

Letters18 May 1999Therapy for Legionnaires DiseasePaul H. Edelstein, MDPaul H. Edelstein, MDUniversity of Pennsylvania Medical Center; Philadelphia, PA 19101-4283 (Edelstein)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-10-199905180-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Johnson raises the important issue of empirical therapy for community-acquired pneumonia. The decision of whether to include treatment of Legionnaires disease in such therapy must be based on the chances of the patient having the disease and on the potential for harm if the disease is untreated. He rightly points out that there is great potential for the emergence of fluoroquinolone antimicrobial resistance if every patient with pneumonia receives that therapy. Empirical administration of a narrow-spectrum β-lactam antimicrobial agent alone may not be adequate therapy for several community-acquired infectious agents, including Mycoplasma pneumoniae, Chlamydia pneumoniae, Haemophilus influenzae, ...References1. Bartlett JG, Breiman RF, Mandell LA, File TM. Community-acquired pneumonia in adults: guidelines for management. The Infectious Diseases Society of America. Clin Infect Dis. 1998;26:811-38. CrossrefMedlineGoogle Scholar2. Niederman MS, Bass JB, Campbell GD, Fein AM, Grossman RF, Mandell LA, et al . Guidelines for the initial management of adults with community-acquired pneumonia: diagnosis, assessment of severity, and initial antimicrobial therapy. American Thoracic Society. Medical Section of the American Lung Association. Am Rev Respir Dis. 1993;148:1418-26. CrossrefMedlineGoogle Scholar3. Bedos JP. Peut-on encore se contenter de l'ampicilline seule pour traiter les pneumopathies communautaires? Presse Med. 1998;27:1440-1. MedlineGoogle Scholar4. Fishman N, Morgan A, Green S, Edelstein PH. Guidelines for Antibiotic Therapy at the Hospital of the University of Pennsylvania, 1998 Edition. www.med.upenn.edu/bugdrug/. Last Update: 16 November 1998. Accessed on 1 December 1998. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania Medical Center; Philadelphia, PA 19101-4283 (Edelstein) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAntimicrobial Chemotherapy for Legionnaires Disease: Time for a Change Paul H. Edelstein Therapy for Legionnaires Disease James R. Johnson Metrics Cited ByAzithromycin in the Treatment of Legionella Pneumonia Requiring Hospitalization 18 May 1999Volume 130, Issue 10Page: 864KeywordsAntimicrobial resistanceAntimicrobialsLegionellosisMedical risk factorsMycoplasma pneumoniaeOutpatientsPathogensPatientsPenicillinPneumonia Issue Published: 18 May 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
May 9, 2001
Journal: JAMA (2001)

Stuart Jon Spechler, MD; Edward Lee, MD; Dennis Ahnen, MD; Raj K. Goyal, MD; Ikuo Hirano, MD; Francisco Ramirez, MD; Jean-Pierre Raufman, MD; Richard Sampliner, MD; Thomas Schnell, MD; Stephen Sontag, MD; Z. Reno Vlahcevic, MD; Renee Young, MD; William Williford, PhD
Small-bowel endoscopy
Authors: L. Fry, K. Vormbrock, C. Olano, K. Mönkemüller
Journal: Endoscopy (2011)

Small-bowel endoscopy is now an essential tool for the investigation of patients with suspected small-bowel disorders. The current endoscopic methods to investigate the small-bowel lumen are: video capsule endoscopy (VCE) and device-assisted enteroscopy (DAE). DAE comprises single balloon, double balloon, and spiral enteroscopy. The interest in small-bowel diseases and methods to diagnose and treat them endoscopically continues to increase, as reflected by the contributions to this year’s Digestive Disease Week (7 – 10 May 2011; Chicago, Illinois, USA).
A novel role for phagocytosis-like uptake in herpes simplex virus entry
Authors: Christian Clement, Vaibhav Tiwari, Perry M. Scanlan, Tibor Valyi-Nagy, Beatrice Y.J.T. Yue, Deepak Shukla
Journal: The Journal of Experimental Medicine (2006)

It is becoming increasingly clear that herpesviruses can exploit the endocytic pathway to infect cells, yet several important features of this process remain poorly defi ned.Using herpes simplex virus-1 (HSV-1) as a model, we demonstrate that endocytosis of the virions mimic many features of phagocytosis.During entry, HSV-1 virions associated with plasma membrane protrusions followed by a phagocytosis-like uptake involving rearrangement of actin cytoskeleton and traffi cking of the viri ons in large phagosome-like vesicles.RhoA GTPase was activated during this process and the mode of entry was cell type-specifi c.Clathrin-coated vesicles had no detectable role in virion traffi cking as Eps15 dominant-negative mutants failed to affect HSV-1 uptake.Binding and fusion of the virion envelope with the phagosomal membrane is likely facilitated by clustering of nectin-1 (or HVEM) in phagosomes, which was observed in infected cells.Collectively, our data suggests a novel mode of uptake by which the virus can infect both professional and nonprofessional phagocytes.
Subgroup analyses of a randomized two-by-two factorial phase II trial comparing neoadjuvant chemotherapy with 2 and 4 courses of cisplatin/S-1 (CS) and docetaxel/cisplatin/S-1 (DCS) as neoadjuvant chemotherapy for locally advanced gastric cancer
Authors: T. Hayashi, T. Yoshikawa, K. Sakamaki, K. Nishikawa, K. Fujitani, K. Tanabe, Y. Ito, T. Matsui, A. Miki, T. Fukunaga, H. Nemoto, Y. Kimura, N. Hirabayashi
Journal: Annals of Oncology (2019)