tbuckley/cabot-search huggingface dataset:
A TRUE PATRIOT.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Future requirements for colonoscopy in Britain. Report by the Endoscopy Section Committee of the British Society of Gastroenterology.
Journal: Gut (1987)

Abstract Current gastroenterological opinion is that colonoscopy provides the most accurate technique for diagnosing structural colonic disease, especially neoplasia. A strong case has been made for continuing colonoscopic surveillance of patients with neoplastic polyps, chronic ulcerative colitis, and after resection of carcinomas. The incidence of these diseases is known, and calculations can be made of the desirable frequency of colonoscopy. These indicate that about 160 colonoscopies per 100,000 population per year are required. At present facilities in the United Kingdom fall well below that figure.
Reported HIV Status of Tuberculosis Patients—United States, 1993-2005
Journal: JAMA (2007)

Knowing the human immunodeficiency virus (HIV) status of tuberculosis (TB) patients is essential to optimal patient management. TB is an acquired immunodeficiency syndrome (AIDS)-defining opportunistic condition. Patients with both TB and HIV infection are five times more likely to die during anti-TB treatment than patients who are not HIV infected (CDC, unpublished data, 2003). HIV infection is the greatest known risk factor for progression from latent TB infection to TB disease. In the United States, after TB exposure and infection, HIV-infected persons who do not receive appropriate treatment progress to TB disease over 5 years at a rate 10 times greater than that for persons not infected with HIV. In 1989, CDC recommended that all TB patients be offered HIV testing and, in 2006, called for routine HIV screening of all TB patients after the patient is notified that testing will be performed, unless the patient declines (opt-out screening). In addition to enabling optimal patient management, knowing the HIV status (i.e., positive or negative) of TB patients helps public health agencies to identify HIV-infected contacts of TB patients. Highly active antiretroviral therapy (HAART) can reduce the progression to TB disease, TB relapse, and death. To assess reported HIV status of TB patients and selected characteristics of TB patients with HIV infection, CDC analyzed data from the U.S. National TB Surveillance System for the period 1993-2005. This report summarizes the results of that analysis, which indicated that 1) reporting of HIV status among TB patients increased from 35% in 1993 to 68% in 2003, 2) HIV status of 31% of TB patients was unknown in 2005, 3) 9% of TB patients were HIV positive in 2005, and 4) groups of TB patients at greater risk for HIV infection included injection-drug users (IDUs), noninjection-drug users (NIDUs), homeless persons, non-Hispanic blacks, correctional-facility inmates, and alcohol abusers. Increased promotion of routine HIV testing and rapid HIV tests might increase acceptability of testing, which would allow health-care providers to know the HIV status of a greater percentage of TB patients and enable them to provide optimal care.
Reduction of left ventricular hypertrophy (LVH) by antihypertensive therapy: Results of a meta-analysis of all double-blind randomized studies Roland E. Schmieder, Markus P. Schneider, Peter Martus, Franz H. Messerli, Arnfried U. Klingbeil. University of Erlangen-N�rnberg, Dept. of Medicine IV and Biostatistics, N�rnberg, Germany, Ochsner Clinic, New Orleans, LA
Journal: Journal of the American College of Cardiology (2001)
Nearly 400 Cases Reported in<i>Salmonella</i>Heidelberg Outbreak
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Public Service.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advances in Surgery
Authors: Joel W. Baker
Journal: JAMA (1965)

This first volume of a proposed series presents six concise, factual, and critical essays written by respected authorities on surgical subjects which are at the frontiers of clinical development. The breadth of the topics selected exceeds the interest of most individual surgeons, but each surgeon and student will find one or more essays valuable in bringing together a mass of clinical and research work into a clear and comprehensive medical progress report. Scholars will find valuable the complete bibliographies after most chapters. W. T. Mustard briefly describes the operative procedures currently offered for congenital cardiac anomalies and fairly presents the results. The modest omission of his own recently introduced operation for transposition of the great vessels is disappointing. A Peter Bent Brigham group under F. D. Moore critically evaluates isotopic and dyedilution methods of measuring blood volumes, and emphasizes the difficulties of establishing normal values, the need for multiple equilibrium
Route of Antibiotic Administration in Superficial Impetigo
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AUSTRALIA
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer and the coroner
Authors: G. K. Murphy
Journal: JAMA (1977)

There exist few reports concerning cancer presenting in forensic autopsies. This study of 1,300 consecutive forensic autopsies yielded 22 cases of single cancers (1.7%) of multiple primary sites and histologic types. The forensic autopsy affords unique opportunity to study not only diagnosed and treated trauma, disease, and cancer, but the natural evolution of untreated cancer as well. Clinically occult cancer is not uncommon and may eventually present clinically or at autopsy in unusual fashion. Advanced cancer may, sometimes on initial presentation, be responsible for sudden, unexpected death. Persons with cancer, even in an advanced state, uncommonly commit suicide. Conversely, those committing suicide ostensibly because of known cancer infrequently prove to have cancer at autopsy. Through these autopsy studies, the forensic pathologist gains information invaluable for statistical, clinical, and medicolegal purposes, truly fulfilling his role of "community pathologist." (<i>JAMA</i>237:786-788, 1977)
Foreword
Authors: Peter Siersema, Klaus Mönkemüller
Journal: Endoscopy (2018)

In 2019, Endoscopy celebrates its 50th birthday. From its beginning, Endoscopy has been at the vanguard in advancing the art and science of gastrointestinal endoscopy. The word “endoscopy” comes from the Greek ἔνδον (éndon) or inside, and σκοπεῖν (skopein)‚ to observe. Indeed, the essence of every endoscopy is to carefully observe and make a diagnosis, followed increasingly often by endoscopic therapy. Translating this concept into everyday clinical practice around the world remains the core purpose of our journal. Approximately a decade after the introduction of the fiberoptic gastroscope, endoscopists were already beginning to use this instrument to perform therapeutics in the GI tract, such as injecting bleeding ulcers or resecting colon polyps. Thus, gastrointestinal endoscopy rapidly progressed from a specialty focused on diagnosis to a discipline dealing with intervention and treatment.
Reply
Authors: Don C. Rockey, D. Montgomery Bissell
Journal: Hepatology (2006)

Imaging techniques hold promise for the noninvasive assessment of liver fibrosis. However, at the current time most of the available modalities have limitations. For example, ultrasound with microbubble contrast examines the transit time of blood through the liver and has been touted mainly for the diagnosis of cirrhosis.1 This test and phosphorus spectroscopy (i.e., phosphomonoester to phosphodiester ratios) appear to be capable of tracking the progression of fibrosis but are no more sensitive or specific than serum tests, particularly for intermediate levels of fibrosis.2 Also, phosphorus spectroscopy requires hardware that is available only in research centers. Proton spectroscopy identifies various metabolites (choline and aliphatic hydrocarbons, among others), which may be altered in both steatosis and fibrosis. Thus, its specificity for fibrosis remains to be demonstrated. It can be performed on a standard 1.5 Tesla clinical imager (with dedicated technical assistance), but informative spectra may require higher field strength magnets (3 or 7 T), which at present are research tools only. Diffusion-weighted magnetic resonance (MR) imaging can distinguish cirrhosis and chronic hepatitis from normal liver but with substantial overlap between the groups.3 We look forward to further refinements in each of these various modalities. The combination of proton spectroscopy and diffusion-weighted MR has proven informative for a variety of brain injuries4 and may be worthy of study also for noninvasive assessment of liver fibrosis. Don C. Rockey*, D. Montgomery Bissell , * University of Texas Southwestern Medical Center Dallas, TX, University of California San Francisco San Francisco, CA.
Regional Anesthesia (Victor Pauchet's Technique).
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HAVE YOU WRITTEN TO YOUR SENATOR?
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIPG-73. CLEE011XUS17T (NCT 02607124): A PHASE I/II STUDY OF RIBOCICLIB (LEE011) FOLLOWING RADIATION THERAPY (RT) IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG)
Authors: Mariko DeWire, Christine Fuller, Trent Hummel, Lionel Chow, Ralph Salloum, Luke Pater, Rachid Drissi, Qing Lu, Charles Stevenson, Adam Lane, John Breneman, David Witte, James Leach, Maryam Fouladi
Journal: Neuro-Oncology (2018)

Dysregulation of the cyclin dependent kinase-retinoblastoma (CDK-RB) pathway is observed in DIPG and HGG. Ribociclib (LEE011) is an oral inhibitor of CDK4/CyclinD1 and CDK6/CyclinD3 complexes that induces RB hypophosphorylation and cell-cycle arrest. Eligible patients with newly-diagnosed DIPG or HGG received ribociclib at the recommended phase 2 dose (RP2D) 350 mg/m2/day once daily for 3 weeks/one week off every 28 days following radiation therapy. Feasibility endpoints included tolerability of ribociclib at least 6 courses, > 2 weeks delay in the start of any course or discontinuation of the protocol therapy after one dose modification. Early efficacy was measured by overall survival (OS). PROMIS assessments were completed prospectively in eligible patients. Among 11 patients enrolled, ten were evaluable patients (median age: 7.5 years, range: 3.8–20.1; 9 DIPG, 1 HGG), three patients required dose reduction for grade 4 neutropenia; one patient came off therapy for hematological toxicity following course 4. The median number of courses was 7 (range: 3–14). The most common Grade 3/4 toxicity was myelosuppression. After two cycles of therapy, MRI evaluations in five patients revealed increased necrotic volume, associated with new neurological symptoms in three patients. The median OS for DIPG was 15.5 months (range: 10–17+). Three remain alive. OS for HGG patient was six months. Ribociclib administered post radiation therapy is feasible in this patient population. Increase in necrosis may represent treatment effect. Volumetric measurements warrant further investigations in evaluating tumor when necrosis is present. Correlative studies will be presented at the meeting.
<b>Highlights</b>
Journal: JAMA Psychiatry (2014)

Using 31 P magnetization transfer magnetic resonance spectroscopy, which allows the quantification of the flow of high-energy phosphate molecules through enzymatic reactions, Du et al explored bioenergetic abnormalities in schizophrenia.There was a statistically significant 22% reduction in the creatine kinase reaction rate in the frontal lobe in patients with chronic schizophrenia.In addition, the pH was reduced, consistent with a shift toward glycolysis and buildup of lactic acid.
Mechanisms of Chloroform and Carbon Tetrachloride Toxicity in Primary Cultured Mouse Hepatocytes
Authors: Randall J. Ruch, James E. Klaunig, Norman E. Schultz, Augusta B. Askari, David A. Lacher, Michael A. Pereira, Peter J. Goldblatt
Journal: Environmental Health Perspectives (1986)

Mechanisms of chloroform (CHCl3) and carbon tetrachloride (CCl4) toxicity to primary cultured male B6C3F1 mouse hepatocytes were investigated. The cytotoxicity of both CHCl3 and CCl4 was dose- and duration-dependent. Maximal hepatocyte toxicity, as determined by lactate dehydrogenase leakage into the culture medium, occurred with the highest concentrations of CHCl3 (5 mM) and CCl4 (2.5 mM) used and with the longest duration of treatment (20 hr). CCl4 was approximately 16 times more toxic than CHCl3 to the hepatocytes. The toxicity of these compounds was decreased by adding the mixed function oxidase system (MFOS) inhibitor, SKF-525A (25 microM) to the cultures. The addition of diethyl maleate (0.25 mM), which depletes intracellular glutathione (GSH)-potentiated CHCl3 and CCl4 toxicity. The toxicity of CHCl3 and CCl4 could also be decreased by adding the antioxidants N,N'-diphenyl-p-phenylenediamine (DPPD) (25 microM), alpha-tocopherol acetate (Vitamin E) (0.1 mM), or superoxide dismutase (SOD) (100 U/mL) to the cultures. These results suggest that: in mouse hepatocytes, both CHCl3 and CCl4 are metabolized to toxic components by the MFOS; GSH plays a role in detoxifying those metabolites; free radicals are produced during the metabolism of CHCl3 and CCl4; and free radicals may be important mediators of the toxicity of these two halomethanes.
Genetic Toxicology: Current Status of Methods of Carcinogen Identification
Authors: Raymond W. Tennant, Errol Zeiger
Journal: Environmental Health Perspectives (1993)

A critical aspect of the efforts to relate the results of short-term genetic toxicity tests with those from long-term rodent tests for carcinogens is the quality and consistency of the studies conducted by the National Toxicology Program. Analysis of the results in relationship to chemical structure has shown that mutagenic potential is a primary risk factor for carcinogen identification. Chemicals positive in the Salmonella assay-generally possess "structural alerts" for electrophilic interactions, are predominantly represented among chemicals producing trans-species carcinogenic effects in rodents, and among those identified as carcinogenic to humans. Current efforts are aimed at defining toxicological, structural, and mechanistic properties of nonmutagens that are carcinogenic in rodents.
Futility and avoidance. Medical professionals in the treatment of obesity
Authors: A. Frank
Journal: JAMA (1993)

TWENTY years ago, I changed course in my internal medicine practice and decided, rather deliberately, to work on the problem of obesity. My friends, my colleagues, and my family thought I was crazy. The warnings were clear. "Don't risk your credibility and your career." "Don't venture into a part of medicine that no one takes seriously." "Don't move into the world of quacks and charlatans." My brother, a thoughtful, professorial cardiologist, assessed the situation in most negative terms. "The guys who deal with obesity are the sleaziest guys in medicine. Pills and shots!" he shouted. Another friend, also comfortably cloistered in academia, could not imagine how I could possibly want to spend my time working with fat, middle-aged ladies: "What on earth is there to talk about?" <h3>Taking the Plunge</h3> Even in my naive youth I was not oblivious to the risks involved in dealing with obesity. Although my credentials