tbuckley/cabot-search huggingface dataset:
Antibiotic Therapy in Patients Hospitalized With Acute Chronic Obstructive Pulmonary Disease
Authors: Samy Suissa, Pierre Ernst
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction of HIV‐1 Nef‐specific cytotoxic T lymphocytes by Nef‐expressing DNA vaccine
Authors: Yusuke Asakura, Kenji Hamajima, Jun Fukushima, Hiroshi Mohri, Takao Okubo, Kenji Okuda
Journal: American Journal of Hematology (1996)

Recently, some individuals who have remained seronegative despite definite exposure to HIV-1 have been reported. Among these individuals, an unusually high frequency of HIV-1 Nef-specific cytotoxic T lymphocytes was observed. Direct injection of plasmid DNA encoding foreign antigen can elicit both cell-mediated immunity and antibody responses (DNA vaccine). We constructed an HIV-1 Nef-expressing plasmid, and we induced HIV-1 Nef-specific cytotoxic T lymphocytes. This is the first report of inducing HIV-1 Nef-specific cytotoxic T lymphocytes by DNA vaccine. © 1996 Wiley-Liss, Inc.
COLPOPERINEORRHAPHY AND THE STRUCTURES INVOLVED.
Authors: BYRON ROBINSON
Journal: JAMA (1898)

The structures involved in the repair of a defective perineum are muscles and fasciæ. The operative procedure consists in denudation with coaptation or flapsplitting methods. Notwithstanding the successful claims in the varied surgical methods of colpoperineorrhaphy the anatomical basis is neither generally nor perfectly understood. It is probable, however, that the essential success lies in the reunion of the separated levator ani muscle by means of its fasciæ superior and inferior with some other fasciæ, and also that this success has been chiefly due to deep suturing. The object of this essay is to demonstrate that the chief factor in successful colpoperineorrhaphy is the restoration by the aid of deep sutures of the fasciæ, especially the levator ani fasciæ, superior and inferior. The muscles of the pelvic floor may be divided into two classes:<i>a</i>, the deep layer—the levator ani coccygeus and pyriformis;<i>b</i>, the superficial layer—the transverse perinei, bulbo-cavernosus
Erratum for the Research Article: “The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity” by M. Wieczorek, J. Tcherkezian, C. Bernier, A. E. Prota, S. Chaaban, Y. Rolland, C. Godbout, M. A. Hancock, J. C. Arezzo, O. Ocal, C. Rocha, N. Olieric, A. Hall, H. Ding, A. Bramoullé, M. G. Annis, G. Zogopoulos, P. G. Harran, T. M. Wilkie, R. A. Brekken, P. M. Siegel, M. O. Steinmetz, G. C. Shore, G. J. Brouhard, A. Roulston
Journal: Science Translational Medicine (2017)
Preeclampsia: Pathophysiology, Diagnosis, And Management
Authors: M. Lindheimer
Journal: Annual Review of Medicine (1989)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More
The Capillary Network of Normal and Emphysematous Human Lungs Studied by Injections of Indian Ink
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Sensorimotor Circuit in Mouse Cortex for Visual Flow Predictions
Authors: Marcus Leinweber, Daniel R. Ward, Jan M. Sobczak, Alexander Attinger, Georg B. Keller
Journal: Neuron (2017)

(Neuron 95, 1420–1432; September 13, 2017) In the original article, there was an error in the reported percentage and number of A24b/M2 axons with activity onsets that precede running onset. The percentage of A24b/M2 axons with significant running onset responses that precede running onset is 30% (508 of 1,675). All analysis based on these numbers and Figure S2, which shows the same data, were correct. This error does not affect any of the conclusions of the study. In addition, there was an error in the methods in the description of the timing of the injection of the ibotenic acid for the chronic lesions of A24b. Ibotenic acid was injected 24 hr prior to the imaging experiments. The authors regret these errors and any confusion that may have arisen as a result of them. These errors have now been corrected in the article online. A Sensorimotor Circuit in Mouse Cortex for Visual Flow PredictionsLeinweber et al.NeuronSeptember 13, 2017In BriefTop-down input to visual cortex from prefrontal areas is involved in attentional and contextual modulation of sensory responses. Leinweber et al. argue that, in the mouse, top-down input to V1 from A24b/M2 carries a prediction of visual flow given movement. Full-Text PDF Open Archive
On Anger
Authors: ALBERT ROTHENBERG
Journal: American Journal of Psychiatry (1971)

The general assumption that anger is a manifestation of aggression has influenced all theories about both aggression and anger. The author believes, however, that there are clear distinctions between anger and hostility, a clear derivative of aggression, and that there are important distinctions between anger and: rage, hate, and violence. Primarily, anger has strong communication aspects for human beings and therefore has great constructive potential despite the fact that anger and anxiety are highly related.
Rituximab / Bendamustine
Authors: Carol Snyder Halberstadt
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antiphospholipid Antibody
Authors: Michael D. Lockshin
Journal: JAMA (1997)

<h3>CASE PRESENTATION</h3> At the age of 22 years, a Hispanic woman developed joint pain, fatigue, rash, and thrombocytopenia. Results of antinuclear and anti-DNA antibody tests were positive. Urinalysis and renal function test results were normal. Systemic lupus erythematosus (SLE) was diagnosed, and hydroxychloroquine sulfate and nonsteroidal anti-inflammatory drugs were prescribed. She did well until she was seen again at age 29 years, when she developed scotomata following a first-trimester spontaneous abortion. Findings of a neurological evaluation, including magnetic resonance imaging, electroencephalography, and Doppler studies, were unremarkable. At age 30 years, severe intrauterine growth restriction, hypertension, and proteinuria complicated a pregnancy, which ended with fetal death at 22 weeks. At age 32 years, the patient sought another opinion. This examination revealed normal vital signs, slight patches of malar erythema, lupus rash, livedo reticularis (Figure), and a loud apical systolic murmur. Her platelet count was 96X10<sup>9</sup>/L. Prothrombin time was 13.0
Correction: Article on a Phase II Trial of Vorinostat in Metastatic Breast Cancer
Journal: Clinical Cancer Research (2008)

In the article by Luu and colleagues in the November 1, 2008, issue of Clinical Cancer Research, the authors were listed in incorrect order. The correct order of authors is as follows: Thehang H. Luu, Robert J. Morgan, Lucille Leong, Dean Lim, Mark McNamara, Jana Portnow, Paul Frankel, David D. Smith, James H. Doroshow, Carol Wong, Ana Aparicio, David R. Gandara, and George Somlo.Luu TH, Morgan RJ, Leong L, et al. A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium Study. Clin Cancer Res 2008;14:7138–42.
Cancer Incidence in a Population of Jewish Women at Risk of Ovarian Cancer
Authors: Alexander Liede, Beth Y. Karlan, Rae Lynn Baldwin, Lawrence D. Platt, Graciela Kuperstein, Steven A. Narod
Journal: Journal of Clinical Oncology (2002)

To evaluate the incidence and clinical characteristics of ovarian and other cancers in a cohort of women at risk of developing ovarian cancer.The Gilda Radner Ovarian Cancer Detection Program in Los Angeles, CA, was established in 1991 to study the efficacy of screening in the early detection of ovarian cancer. We present findings from a historical cohort of 290 Jewish women who were offered BRCA testing for three common founder mutations (BRCA1 185delAG and 5382insC and BRCA2 6174delT).In 10 years, 17 cancers were observed (1,111 per 100,000 per year), including six breast and eight ovarian or related cancers. A high proportion of cancers of peritoneal origin was observed. The majority (86%) of women with incident breast or ovarian/peritoneal cancer carried a mutation in the BRCA1 gene. The overall cancer incidence among carriers of mutations in the BRCA1 gene was estimated to be 5,450 per 100,000 per year, corresponding to a cumulative incidence of 47.5% at 10 years. In contrast, the cumulative incidence of cancer among noncarriers was 2.5% (P < 10(-8)). After adjustment for sampling, the risks to BRCA1 mutation carriers at 10 years were estimated to be 21% for ovarian/peritoneal/tubal cancer, 16% for breast cancer, and 36% for all cancers.The excess risk of breast and ovarian cancer in Jewish women with a family history of ovarian cancer is largely attributable to mutations in BRCA1. Intensive surveillance by use of CA-125 and ultrasound does not seem to be an effective means of diagnosing early-stage ovarian cancer in this high-risk cohort.
Questions and Answers
Authors: Neil J. Stone
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE THERAPY OF THE COOK COUNTY HOSPITAL
Authors: BERNARD FANTUS
Journal: JAMA (1934)

<h3>THERAPY OF CARBUNCLE</h3> Carbuncle is a deep seated intradermal staphylococcic infection, which differs from furuncle (q. v.) in being characterized by multiple foci of necrosis and terminating in gangrene. Because of radical difference of treatment, malignant pustule, or anthrax (q. v.), must be differentiated from carbuncle. Anthrax is characterized by the early formation of a blister and of a hard, black, painless and insensitive slough that becomes surrounded by a halo of vesicles, in the fluid of which smears show anthrax bacilli. History of exposure to infected animals or animal products may lead to suspicion of anthrax. <h3>LOCAL TREATMENT OF CARBUNCLE</h3> There is no use in wasting time with hot moist dressings. Possibly roentgen irradiation (300 roentgens, 140 kilovolts, with a filter of 0.25 mm. of copper and 1 mm. of aluminum) may be of value if the case does not seem ripe for radical treatment. <h3>Surgical Treatment.</h3> Crucial incisions
RIGID SPINE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
评估萎缩性面部光损伤的光数字标准
Authors: J. Ayer, A. Ahmed, E. Duncan-Parry, P. Beck, T.W. Griffiths, R.E.B. Watson, C.E.M. Griffiths
Journal: British Journal of Dermatology (2018)

皮肤衰老会随着时间自然发生。这个过程会被阳光等因素加速,这种现象叫做光损伤。白皮肤人群会出现肥大性面部光损伤(HP),这种疾病会产生肥大粗糙的皱纹,看似皮革,手感粗糙,通常带有不均匀的颜色。但是,现在出现了另一种子类别光损伤,这种病会让患者皮肤变得薄、亮而有光泽,导致血管破裂,出现微小的皱纹,还会增加某些皮肤癌的风险。这种光损伤被称为萎缩性光损伤(AP)。这项研究在英国曼彻斯特开展,旨在制定评估和衡量AP严重性的标准。对于HP,已有这样的标准,但还没有衡量AP的相应标准。其方法是建立包含393张AP患者照片的库,选择代表不同严重性的五张图片组成标准。每张图片编为0至8号,0代表无光损伤,8代表严重AP,构成九分的标准。光数字标准的检验依据是描述萎缩性光损伤特征,而不使用图片的标准(描述性标准)。该研究清晰展现,光数字标准在可重复性(即不同测试人员得出相同结果)和再现性(相同测试人员在一周后得出相同结果)上显著优于描述性标准。该标准将成为临床研究AP评估和分级的宝贵工具,尤其是在这类群体患某些皮肤癌的风险更高的情况下。
Medical staffing and training in the West Midlands region.
Authors: J Parkhouse, D Bennett, J Ross
Journal: BMJ (1987)

In 1984 the West Midlands Regional Health Authority set up a working party to study and make recommendations about the coordination of medical and dental training and staffing in the region. Data collectionThe first requirement was good information about current staffing levels and difficulties.Visits were made to each of the 22 health districts in the region to establish baseline data on all hospital medical and dental staff including clinical assistants, honorary and supernumerary staff, plus dependence on locums, etc.This provided improved regional data, and the way was opened for annual updating and refinement.The first update has now taken place.The next step was to obtain estimates of future manpower needs.This can be done in various ways, all of which are imprecise and open to criticism.Our procedure was to make a second visit to each district, at which we met representatives of clinical specialties, who often acted as spokesmen for colleagues in related disciplines.The actual pattern of attendance varied, and it was not possible to meet doctors from every specialty and subspecialty in every district.It was emphasised, however, that opinions collected at these visits would represent merely the start of a dialogue, during which we hoped for ample opportunity to improve and amplify future projections.We asked about staffing needs in 10 years' time in order to have some kind ofidealistic goal beyond the preoccupations ofthe immediate future.Emphasis was placed on consultant posts, having regard to district plans and commitments and local knowledge of population and age and sex structure projections, and hence the staff requirements for good patient care.We wished this, rather than likely funding or preconceived junior to consultant staffratios, to be the basis of the estimates made.We indicated that junior staffing would be analysed as a second stage, regionally, from the consultant figures obtained.As a working basis it was assumed, however, that no more junior doctors than at present were likely to be available in 10 years' time and possibly fewer.Despite this, some demands for additional juniors were not surprisingly made, especially in connection with new hospital developments on green field sites.These demands were simply noted as we thought it important to record so far as possible the estimates of those doing the actual work in each district.
Intensive care units, scarce resources, and conflicting principles of justice
Authors: H. T. Engelhardt
Journal: JAMA (1986)

HUMANS often have the aspirations of deities, though never the resources. Intensive care units (ICUs) provide an example of the desire to provide an optimal level of care for all who require it, where "optimal" is taken to mean the highest achievable standard of care. However, recent budgetary retrenchments in the provision of funds for health care show that health care is not always an overriding public policy priority. Consequently, as a matter of morality and public policy, it will be necessary to determine at what point undesirable standards of health care are simply unfortunate, but not unfair in the sense of constituting a claim on further resources. We explore the distribution of health care resources by addressing the problem of allocating ICU beds (1) when further admissions to an ICU will jeopardize the standard of health care for all those in the ICU, (2) when those eligible for admission
Editor's Note
Authors: Calum A. MacRae
Journal: Circulation (2012)

In the past 3 decades, pharmacotherapy has had a major impact on mortality and morbidity in cardiovascular disease.Few areas of medicine have seen the deployment of preventative therapy on a scale that changes the clinical face of a disorder in the way that statins have transformed atherosclerosis.However, in part as a result of these successes, more recent trials have exhibited more modest effects, and the pharmaceutical industry has become wary of large trials in the cardiovascular arena.At the same time, advances in genetics and quality measurement have driven calls to match drugs with disease biology in an effort to improve efficacy and reduce toxicity-the personalization of therapy.One direct inference of personalized medicine is a need for novel drugs addressing the molecular mechanisms of each patient's disorder.Rigorous target identification remains a major hurdle for the discovery of new drugs, and the validity of several cherished cardiovascular targets has recently been challenged by the results of expensive clinical trials.Engaging clinicians and scientists alike to address questions at this translational interface has never been more important.In this issue, the article by Michael Marber and colleagues on p38alpha mitogen-activated protein kinase inhibitors in ischemic heart disease is the first in an occasional miniseries examining emerging therapeutic targets in the cardiovascular space.These reviews will focus on the rationale for the individual molecules as targets, the preclinical data supporting their clinical positioning, and early clinical data.
Evaluation of a new antidiuretic agent, desmopressin acetate (DDAVP)
Authors: M. E. Kosman
Journal: JAMA (1978)

Desmopressin acetate is a synthetic vasopressin analogue administered by the intranasal route. It is long-acting and well tolerated and may be the agent of choice for treating central diabetes insipidus. (<i>JAMA</i>240:1896-1897, 1978)
THE SURRENDER OF EDDYISM.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal