tbuckley/cabot-search huggingface dataset:
Cholesterol-Lowering Effects of Psyllium Hydrophilic Mucilloid
Authors: Larry P. Bell
Journal: JAMA (1989)

Psyllium hydrophilic mucilloid was examined for its ability to lower serum cholesterol levels in hypercholesterolemic patients. Seventy-five patients with mild to moderate hypercholesterolemia were evaluated in this randomized, double-blind, placebo-controlled parallel study. Patients were treated with a Step I diet for 12 weeks before receiving placebo or 3.4 g of psyllium (equivalent to 1 teaspoon) three times per day for 8 weeks. Compared with placebo, psyllium achieved an additional 4.8% reduction in total cholesterol level, 8.2% reduction in low-density lipoprotein cholesterol level, and 8.8% reduction in apolipoprotein B level. Psyllium did not significantly affect blood pressure or levels of high-density cholesterol, triglycerides, serum glucose, or iron. Reported adherence to diet and treatment was excellent, and no significant adverse side effects were noted. These results indicate psyllium hydrophilic mucilloid is an effective and well-tolerated adjunct to diet in the management of mild to moderate hypercholesterolemia. (<i>JAMA</i>. 1989;261:3419-3423)
Incidence of Fatigue Symptoms and Diagnoses Presenting in UK Primary Care from 1990 to 2001
Authors: Arlene M Gallagher, Janice M Thomas, William T Hamilton, Peter D White
Journal: Journal of the Royal Society of Medicine (2004)

Little is known about whether the incidence of symptoms of fatigue presented in primary care, and the consequent diagnoses made, change over time. The UK General Practice Research Database was used to investigate the annual incidence of both fatigue symptoms and diagnoses recorded in UK primary care from 1990 to 2001. The overall incidence of all fatigue diagnoses decreased from 87 per 100 000 patients in 1990 to 49 in 2001, a reduction of 44%, while postviral fatigue syndromes decreased from 81% of all fatigue diagnoses in 1990 to 60% in 2001. Chronic fatigue syndrome (CFS) and myalgic encephalomyelitis (ME) together increased from 9% to 26% of all fatigue diagnoses. The incidence of fibromyalgia increased from less than 1 per 100 000 to 35 per 100 000. In contrast, there was no consistent change in the incidence of all recorded symptoms of fatigue, with an average of 1503 per 100 000, equivalent to 1.5% per year. CFS/ME and fibromyalgia were rarely diagnosed in children and were uncommon in the elderly. All symptoms and diagnoses were more common in females than in males. The overall incidence of fatigue diagnoses in general has fallen, but the incidence rates of the specific diagnoses of CFS/ME and fibromyalgia have risen, against a background of little change in symptom reporting. This is likely to reflect fashions in diagnostic labelling rather than true changes in incidence.
GENETICS
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A 'Green Sheet' Review
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment
Authors: M Swain
Journal: Hepatology (1997)

Fatigue is a common complaint in patients with liver disease; however, the etiology of fatigue is poorly understood and no therapeutic options are available to treat it. Altered central neurotransmission, especially serotonergic, appears to play a role in the genesis of fatigue. In this study, we describe a rat model of fatigue assessment using a swim tank, and we used this model to document the degree of fatigue in rat models of cholestasis caused by bile duct resection (BDR) and of hepatitis caused by carbon tetrachloride (CCl4) administration. Fatigue was quantitated as the time spent floating and struggling over a 15-minute period after placement in the swim tank, and an overall activity score was calculated. Using this technique, BDR rats exhibited significantly enhanced floating times and an overall reduction in activity score compared with noncholestatic controls (P ≤ .01). On the other hand, CCl4-treated rats showed a marked variability in floating and struggling times and activity scores such that, overall, CCl4-treated rats were not significantly different from normal controls. Therefore, we used BDR and noncholestatic control rats to examine the effects of a serotonin (5HT1A) receptor agonist (LY293284) on cholestasis-associated fatigue. BDR rats treated with LY293284 (0.3 mg/kg subcutaneously 24, 5, and 1 hour before placement in the swim tank) showed marked reductions in floating times and an increase in overall activity scores compared with BDR controls (P ≤ .001). LY293284 was without effect in noncholestatic animals. These results suggest that fatigue can be quantitated in rat models of liver disease and that 5HT1A receptor agonists may provide a useful therapeutic tool in the treatment of cholestatic liver disease- associated fatigue.
Correspondence
Authors: B. Watson, E. L. Rhodes, B. B. J. Majewski
Journal: British Journal of Dermatology (1980)

Journal Article Correspondence Get access B. Watson, B. Watson Department of Dermatology, St Helier Hospital, Carshalton, Surrey Search for other works by this author on: Oxford Academic Google Scholar E. L. Rhodes, E. L. Rhodes Department of Dermatology, St Helier Hospital, Carshalton, Surrey Search for other works by this author on: Oxford Academic Google Scholar B. B. J. Majewski B. B. J. Majewski Department of Dermatology, St Helier Hospital, Carshalton, Surrey Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 103, Issue 1, 1 July 1980, Page 120, https://doi.org/10.1111/j.1365-2133.1980.tb15853.x Published: 01 July 1980
Maternal Mosaicism and Down's Syndrome (Mongolism)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Data.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergic skin disorders
Authors: A. P. Kaplan
Journal: JAMA (1987)

ALLERGIC skin diseases are relatively common and, at times, devastating clinical problems that have great socioeconomic impact. In this section, we will provide a basis for understanding the role of immune mechanisms in the cause of certain diseases of the skin and the application of this information to their diagnosis and treatment. <h3>ATOPIC DERMATITIS</h3><h3>Definition</h3> Atopic dermatitis<sup>1,2</sup>is a common dermatitis that is characterized by severe pruritus, frequent onset in infancy, a strong familial propensity, and a tendency toward chronicity. It is referred to as<i>atopic dermatitis</i>because of its occurrence in individuals who manifest IgE-mediated skin test reactions and who later frequently acquire allergic rhinitis, asthma, or both. Typically, atopic dermatitis begins in early infancy, rarely before age 2 months but before age 6 months in the majority of instances. The expression of the disease in early life, when it occurs as an erythematous, papulovesicular, exudative, intensely pruritic
A REGRETTABLE OVERSIGHT.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polk's Medical Register and Directory of North America, Comprising List of Physicians and Surgeons, Arranged by Location, Giving Postoffice Address with Population, the School Practiced, Date and College of Graduation, All the Existing and Extinct Medical Colleges in the United States and Canada, with Locations, Officers, Number of Professors, Lecturers, Demonstrators, etc., the Various Medical Societies, Penal Reformatory and Charitable State Institutions, Hospitals, Sanitariums, Dispensaries…
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHRONIC BENZENE POISONING IMPROVED BY LIVER
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1889)

(FROM OUR REGULAR CORRESPONDENT.) Does the Yellow Fever Germ Disappear?—Alleged Malarial Complication of the Florida Epidemic —Gibier's Report to the New York Academy of Medicine—Unusual Methods of Acquiring Syphilis —Hospital Sunday Collections—Officers Elected. Dr. Paul Gibier has just presented the report of his experimental researches in yellow fever, made recently in Florida, under the direction of the French Government, to the New York Academy of Medicine, and it is to be noticed that in this report he reasserts his claim to have discovered the microbe of the disease in the intestinal canal. The occasion was an interesting one at the Academy, and the paper was listened to with the closest attention, but, strange to say, there was not, with the exception of the President, Dr. A. Jacobi, a single pathologist of note present, and there was not a word of discussion upon it. Dr. Gibier stated that when he reached
Serum metabolic biomarkers for the differential diagnosis of distal cholangiocarcinoma and pancreas ductal adenocarcinoma
Authors: Rocio IR Macias, Jesus M. Banales, Maria Laura Gutierrez, Ainhoa Lapitz, Luis Muñoz-Bellvis, Adelaida La Casta, Enara Arretxe, Cristina Alonso, Ibon Martínez-Arranz, Luis M. Gonzalez, Rui E. Castro, Matías A Avila, María Luz Martínez-Chantar, Maria Serrano, Luis Bujanda, Jose Marin
Journal: Journal of Hepatology (2020)
Addendum to “General Criteria for Assessing the Evidence for Carcinogenicity of Chemical Substances: Report of the Subcommittee on Environmental Carcinogenesis, National Cancer Advisory Board” (Vol. 58, No.2, February 1977)
Authors: F Rauscher
Journal: JNCI Journal of the National Cancer Institute (1977)

scientific community, it should playa more active, responsive, and responsible role in the identification of activities which, if performed successfully, will contribute to the benefit of people.Such approved high-priority projects can be funded in less than 3 months of receipt of applications and will include: a) unique research opportunities which cannot and should not wait for funding by current lengthy mechanisms; b) unanticipated requirements for reagents, drugs, blood components, equipment, travel; c) program coordination, especially those involving clinical trials and the dissemination of research results to community hospitals; and d) program integration among the American Cancer Society and other organizations, e.g., cancer centers, PSRO's, HMO's, State Health Associations.Approximately $5.0 million will be provided for 1977-78.Most grant awards will be for $15,000 or less.Occasionally, a special situation may require funding at a higher level.Research applications that do not meet the special criteria of this Program may be candidates for the regular research grants program of the Society.Each research application will be reviewed by an outside peer group of scientists whose competence is recognized inthe designated area of research or research resources.In accordance with policies of the American Cancer Society, each application will be reviewed for merit, facilities, and the actual or potential qualifications and productivity of the investigator and the institution.Applications will also be evaluated for the requirement for rapid funding and for relevance, need, and probability of the project's eventual contribution to cancer control in people.Grants will be made for I year and will not be renewable except under unusual circumstances.Send applications (original plus 6 copies) with sufficient information for review of merit, urgency, need, and priority to
A Medical Review of Soviet Russia: IV.--Change in Type and Incidence of Disease
Authors: W. H. Gantt
Journal: BMJ (1926)

Factors.-Although the total of diseases increased enormously during the war and famine, some decreased not only relatively but absolutely.The bad conditions acted as therapeutic agents for some derangements, or at least possessed a compensatory value.The etiological factors begin-ning in 1915 anid culminating in 1920-21 were: (1) The psychical strain of the war and revolu- tion-the loss of home, fortune, and friends, and the uncertainty of the future.t(2) The food: (a) starvation, particularly in fats and proteins, and involving all classes; (b) the indigestible and irritating character of the food, suclh as salt lherring during 1918-19, and later mechanical irritants-as oats, millet, and flax; (c) the elimination of all alcoholic beverages until 1922, and the sharp decrease in tea, coffee, and tobacco.(3) The lodgings-the lacLi of light, warmth, and comfort during the worst years, and the presence of dirt.(4) The physical strain-the necessity for hard manual labour by those not accustomed to it, and the lack of means of locomotion.It is suggestive therapeutically to see which diseases were affected by these conditions.tThe following figures are an analysis of about 5,000 cases from the Erisman Hospital, Leningrad.Adiposity, with which 0.75 per cent. of patients enter- ing the hospital were affected in 1914, decreased to 0.37 per cent. in 1917, and-completely disappeared in 1918-21.§ Chronic alcoholism fell from 1.5 per cent. of patients in 1914, to 0.75 per cent. in 1916, and in 1919 to 0.001 per cent.Diabetes mellitus was absent entirely during the famine years, and podagra showed a marked decrease.Drug addicts were also absent from the roster in 1920-22.Circulatory Diseases.-Withthe exception of nephritis nearly all of these showed a marked increase.,Arteriosclerosis and lhypertelnsion, cardiac neuroses, angina pectoris, myocarditis, and aortic aneurysm were greatly increased.-In1914 disease of the heart and blood vessels constituted 2.7 per cent. of all dispensary patients; in 1918 4.2 per cent.Anaemia and dyspnloea were almost universal and bradycardia was common.These figures indicate that whatever benefit to cardiac disease might lbavb accrued from the lightening of the diet was more than offset by the terrible mental and physical strainof the life of that time.Nephritis did not change its incidence.Eniphysema was slightly increased.Raynaud's disease and chilblains were greatly increased.Previous papers on medical and scientific work in Soviet Russia by.
THE GRAM STAIN IN THE DIAGNOSIS OF CHRONIC GONORRHEA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Report of the Committee from the Section of Obstetrics and Gynecology on a Survey of the Incidence of Puerperal Septicemia in Massachusetts during a Five-Year Period
Journal: New England Journal of Medicine (1932)

Papers and Discussions from The New England Journal of Medicine — A Report of the Committee from the Section of Obstetrics and Gynecology on a Survey of the Incidence of Puerperal Septicemia in Massachusetts during a Five-Year Period