tbuckley/cabot-search huggingface dataset:
Use of horizontal ultrathin gel electrophoresis to analyze allelic deletions in chromosome band 11p15.5 in gliomas
Authors: Irene F. Newsham, Karen M. Gorse, Sandra A. Rempel, John Luckey, James B. Golden, Oliver Bögler
Journal: Neuro-Oncology (2000)

The prognosis for most patients with astrocytic glioma is poor, and postoperative life expectancy has not signicantly improved in the last decade despite advances in diagnosis, surgery, and adjuvant therapy.Progress has been made, however, in cataloging the genetic alterations that occur in these tumors.Studying the allelic changes using loss of heterozygosity analysis has proven to be a reliable and rapid way of identifying genetic alterations fundamental to the pathology of this disease.In this study, we used a series of uorescent-labeled markers and a new horizontal ultrathin gel electrophoresis technology (HUGE; GeneSys Technologies, Inc.) to analyze loss of heterozygosity on 11p15 in a series of 24 matched normal/tumor glioma pairs that included both anaplastic astrocytomas and glioblastomas.These studies signicantly narrowed the region harboring a putative 11p15.5 glioma-associated gene and further suggest that a second gene involved in the pathogenesis of brain tumors may exist, centromeric, in bands 11p15.5-p15.4.
Meta-analysis of randomized control trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitors.
Authors: Christopher J. Richards, Youjin Je, Fabio A. B. Schutz, Toni K. Choueiri
Journal: Journal of Clinical Oncology (2012)

349 Background: Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) have become the cornerstone in the treatment of several malignancies. These drugs have also been associated with an increase in the risk of potentially life-threatening adverse events, such as arterial thrombotic events, bleeding, congestive heart failure, and others. We performed an up-to-date meta-analysis to determine the risk of fatal adverse events (FAEs) in patients with cancer treated with VEGFR TKIs. Methods: MEDLINE and PubMed databases were searched for articles published from January 1966 to February 2011. Eligible studies were limited to trials of US Food and Drug Administration– approved VEGFR TKIs (pazopanib, sunitinib, and sorafenib) that reported on patients with cancer with any primary tumor type, randomized design, and adequate safety profile. Statistical analyses were conducted to calculate the summary incidence, relative risk (RR), and 95% CIs by using random-effects or fixed-effects models on the basis of the heterogeneity of included studies. Results: In all, 4,679 patients from 10 randomized controlled trials (RCTs) were included, with 2,856 from sorafenib, 1,388 from sunitinib, and 435 from pazopanib trials. The incidence of FAEs related to VEGFR TKIs was 1.5% (95% CI, 0.8% to 2.4%) with an RR of 2.23 (95% CI, 1.12 to 4.44; P .023) compared with control patients. On subgroup analysis, no difference in the rate of FAEs was found between different VEGFR TKIs or tumor types. No evidence of publication bias was observed. Conclusions: In a meta-analysis of RCTs, the use of VEGFR TKIs was associated with an increased risk of FAEs compared with control patients.
When to Send for the Doctor and What to Do Before the Doctor Comes.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Infant and Young Child: Its Care and Feeding from Birth Until School Age. A Manual for Mothers.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of Pharyngeal Carriers of Group A Streptococcal Organisms
Authors: Matthew T. Maher
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Cockerill and colleagues<sup>1</sup>present interesting and relevant information that underscores an urgent need for the development of a consensus related to the management of the invasive streptococcal carrier state. As the authors point out, there is currently little agreement among physicians regarding the treatment of patients with asymptomatic streptococcal infection. In fact, some experts view this as a benign condition that poses no direct risk to patients or to their contacts and therefore requires no intervention.<sup>2</sup>As a practical matter, we disagree with this passive posture. The study performed by Cockerill et al and common sense support the notion that eradication of this pathogen in the carrier state seems to serve the best interests of both the child and the community. During a recent outbreak of group A streptococcal disease, our clinic undertook a study that compared 2 currently accepted treatment options for eradication
Metabolism and Toxicity of Styrene
Authors: Kenneth C. Leibman
Journal: Environmental Health Perspectives (1975)

The absorption, blood levels, distribution, excretion, and biotransformation of styrene in man and experimental animals are briefly reviewed. The acute toxicity of styrene appears to be unrelated to its biotransformation. Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility.
Outbreak of Unexplained Illness—Washington, 1994
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Odor of Sanity
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ganciclovir treatment of hepatitis B virus infection in liver transplant recipients
Authors: R GISH
Journal: Hepatology (1996)

To determine the safety and efficacy of ganciclovir treatment of hepatitis B virus (HBV) infection after liver transplantation, nine patients (seven males, two females; mean age, 38 years) with posttransplant HBV infection were treated with ganciclovir for 3 to 10 months. Ganciclovir was administered intravenously at an initial dose of 5 mg/kg/d and then increased to 10 mg/kg/d. Immunosuppressive drug therapy was maintained at low levels. There were no major side effects of ganciclovir therapy. Serum HBV DNA levels decreased by a mean of 90% (range, 42% to 100%), and four of nine patients had no measurable HBV DNA at the completion of therapy. Mean serum alanine aminotransferase levels decreased by 83%. Hepatic expression of HBV antigens and HBV DNA was assessed before and after therapy in six patients and found to be reduced in three patients. The histology activity index was also stabilized or improved in all patients. After discontinuation of therapy, four of nine patients underwent retreatment for 4- to 12-fold elevation of serum HBV DNA and/or biochemical and clinical relapse, that was severe in one patient. This pilot study shows the safety and efficacy of ganciclovir therapy for reducing HBV replication in patients with HBV infection after liver transplantation.
Cranial nerve syndromes. Relation to exogenous and endogenous substances
Authors: M. Scott
Journal: JAMA (1968)

To the Editor:— Must we put up with the indignity of the Master-step-test which reduces the patient-doctor relationship to that of master and slave? The sight of a respectable citizen stumbling over wires while climbing the wobbly steps, evokes the image of Sisyphus pushing his rock up a mountain. In our office we have replaced the "step-test" with a much more dignified bicycle dynamometer. With the exception of some members of our esteemed Canadian mounted police, who, because of their equestrian background are awkward with bicycles and for whom we have devised an electric horse dynamometer, our patients have taken well to the bicycle. More recently we have sharpened diagnostic accuracy with a two-seater, which accommodates not only the patient but also a matched control.
EUROPE IN ADVANCE OF US—A TRIBUTE TO HERMANN KNAPP
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMAgrams
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DOMESTIC ABSTRACTS
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minimising the environmental impact of inhaled therapies: problems with policy on low carbon inhalers
Authors: Duncan Keeley, Jane E. Scullion, Omar S. Usmani
Journal: European Respiratory Journal (2020)

As global citizens, we have a duty to reduce the serious threats posed to planetary well-being and population health by environmental degradation and climate change. These now unquestionable threats to our future are due to human population growth and the resource consumption patterns of the human race. In tandem, as healthcare professionals, we should seek the best possible outcomes of our treatment for our patients and we need to consider equity between different groups of patients. In the speciality of respiratory medicine, the current controversy over how to deal with the role in global warming of the propellants used in pressurised metered dose inhalers (pMDIs) is a very pressing example of how these sometimes conflicting imperatives confront us in our daily practice. Uncritical implementation of policy risks deterioration in patient inhaler choice <http://bit.ly/2RluJti>
Inactivation of Kupffer cells prevents early alcohol-induced liver injury
Authors: Y Adachi
Journal: Hepatology (1994)

It is well recognized that consumption of alcohol leads to liver disease in a dose-dependent manner; however, the exact mechanisms remain unclear. Hypoxia subsequent to a hypermetabolic state may be involved; therefore, when it was observed recently that inactivation of Kupffer cells prevented stimulation of hepatic oxygen uptake by alcohol, the idea that Kupffer cells participate in early events that ultimately lead to alcohol-induced liver disease became a real possibility. The purpose of this study was to test that hypothesis. Male Wistar rats were exposed to ethanol continuously by means of intragastric feeding for up to 4 weeks using the model developed by Tsukamoto and French. In this model, ethanol causes fatty liver, necrosis and inflammation — changes characteristic of alcohol-induced liver disease in human beings. Kupffer cells were inactivated by twice weekly treatment with gadolinium chloride (GdCl3), a selective Kupffer cell toxicant. AST levels were elevated to 192 ± 13 and 244 ± 56 IU/L in rats exposed to ethanol for 2 and 4 wk, respectively (control value, 88 ± 7). This injury was prevented almost completely by GdCl3 treatment. Fatty changes, inflammation and necrosis were also all reduced dramatically by GdCl3 treatment. The average hepatic pathological score of rats treated with ethanol for 4 wk was 4.3 ± 0.6, which was reduced significantly in ethanol- and GdCl3-treated rats to 1.8 ± 0.5 (p<0.05). Rates of ethanol elimination were elevated 2- to 3-fold in rats exposed to ethanol for 2 to 4 wk. This elevation was blocked by GdCl3 treatment. These results demonstrate that GdCl3 prevents alcohol-induced liver injury and suggest strongly that Kupffer cells participate in the early phases of the disease process. Thus, pharmacological manipulation of Kupffer cell function might represent a new approach to clinical management of alcohol-induced liver injury. (Hepatology 1994;20:453-460.)
Very Exacting
Authors: Maurice N. Richter
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Under the heading "Just Words" (<i>JAMA</i><b>189</b>:666 [Aug 31] 1964), Dr. Alexander Gode commented on the properties of a good summary and gave an example of one that could be improved. In so doing, he failed to mention a point on the use of the word "very." In the summary under discussion, he noted that a conversation was "very" exciting and the patient "very" agitated. As the word "very" was put in quotation marks, I suspect that Dr. Gode may not have approved of the word as used in the context mentioned. I note, however, that he used the same word in describing the summary: "I have before me a very excellent summary...." Two questions come to mind. First, in view of his criticism, should the summary be considered excellent, let alone "very" excellent? Second, what does the word "very" contribute, either to his sentence or
Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells
Authors: Marta Serafini, Scott J. Dylla, Masayuki Oki, Yves Heremans, Jakub Tolar, Yuehua Jiang, Shannon M. Buckley, Beatriz Pelacho, Terry C. Burns, Sarah Frommer, Derrick J. Rossi, David Bryder, Angela Panoskaltsis-Mortari, Matthew J. O'Shaughnessy, Molly Nelson-Holte, Gabriel C. Fine, Irving L. Weissman, Bruce R. Blazar, Catherine M. Verfaillie
Journal: The Journal of Experimental Medicine (2007)
Ocular Immunology
Authors: Elise Torczynski
Journal: JAMA (1982)

This book is an excellent review of immunology for the ophthalmologist. Hardly a day passes when the ophthalmologist is not confronted with another disease with immunologic implications. Such was not the case years ago, when the ophthalmologist's main concerns with immunology were acute allergic conjunctivitis and the ocular manifestations of the collagen vascular diseases. Therefore, the text is a welcome addition to the field. The authors provide a lucid and organized account of complicated and involved interactions, including excellent updates on such diseases as sarcoidosis, Stevens-Johnson syndrome, multiple myeloma, and Sjögren's syndrome, all with implications for the eye. A reasonable number of clinical and microscopic photographs, some in color, help to demonstrate the text. In the first chapter, the basic principles of immunology involving lymphocytes and immunoglobulins, as well as cellular and serological reactions, are described in detail. The authors are careful to point out areas of uncertainty or speculation
Chromium-Induced Kidney Disease
Authors: Richard P. Wedeen, Lifen Qian
Journal: Environmental Health Perspectives (1991)

Kidney disease is often cited as one of the adverse effects of chromium, yet chronic renal disease due to occupational or environmental exposure to chromium has not been reported.Occasional cases of acute tubular necrosis (ATN) following massive absorption of chromate have been described.Chromate-induced ATN has been extensively studied in experimental animals following parenteral administration of large doses of potassium chromate (hexavalent) (15 mg/kg body weight).The chromate is selectively accumulated in the convoluted proximal tubule where necrosis occurs.An adverse long-term effect of low-dose chromium exposure on the kidneys is suggested by reports of low molecular weight (LMW) proteinuria in chromium workers.Exces- sive urinary excretion of 53-microglobulin, a specific proximal tubule brush border protein, and retinol-binding protein has been reported among chrome platers and welders.However, LMW proteinuria occurs after a variety of physiologic stresses, is usually reversible, and cannot by itself be considered evidence of chronic renal disease.Chromate-induced ATN and LMW proteinuria in chromium workers, nevertheless, raise the possibility that low-level, long-term exposure may produce persistent renal injury.The absence of evidence of chromate-induced chronic renal disease cannot be interpreted as evidence of the absence of such injury.Rather, it must be recognized that no prospective cohort or case-control study of the delayed renal effects of low-level, long-term exposure to chromium has been published.