tbuckley/cabot-search huggingface dataset:
The Effectiveness of Hydrocortisone in the Management of Severe Infections
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trim21 促进银屑病患者角质形成细胞炎症反应
Journal: British Journal of Dermatology (2021)

为此, 我们首先使用了遗传学上称为敲低技术的技术, 以减少 Trim21 在角质形成细胞中的表达。在“敲低”Trim21 后, 我们进行了进一步的测试, 例如评定血液中与炎症相关的某些化学物质的水平, 以帮助我们确定以 Trim21 为靶点是否可能成为银屑病的潜在治疗方法。
The Thucydides Syndrome
Authors: C. George Ray
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Two articles and an editorial in the Feb 27 issue ofThe Journal<sup>1-3</sup>establish the existence of toxic shock syndrome as a complication of influenza. They also, at least partially, verify the hypothesis that epidemic influenza accompanied by superinfection with noninvasive, toxigenic strains of staphylococci was the explanation for the plague of Athens of 430 to 427 BC. We have proposed the term<i>Thucydides syndrome</i>for this disease.<sup>4</sup> Certain clinical differences exist between the modern cases thus far described and those that occurred in ancient Attica. We believe that these differences can be readily explained in a manner wholly consonant with the known clinical manifestations produced by various staphylococcal exotoxins. The recent cases follow closely the rather rigid diagnostic criteria first described by Todd et al<sup>5</sup>and codified by the Centers for Disease Control. These include the rapid onset of hypotension, scarlatiniform rash followed
Misquotation of Moertel et al.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preface
Authors: Katherine K. Sanford, R. Raymond Gantt, William G. Taylor
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Preface Get access Katherine K. Sanford, Katherine K. Sanford Tissue Culture Section, Laboratory of Biology National Cancer Institute, National Institutes of Health Public Health Service U.S. Department of Health, Education, and Welfare Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Raymond Gantt, R. Raymond Gantt Tissue Culture Section, Laboratory of Biology National Cancer Institute, National Institutes of Health Public Health Service U.S. Department of Health, Education, and Welfare Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar William G. Taylor William G. Taylor Tissue Culture Section, Laboratory of Biology National Cancer Institute, National Institutes of Health Public Health Service U.S. Department of Health, Education, and Welfare Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 53, Issue 5, November 1974, Page 1429, https://doi.org/10.1093/jnci/53.5.1429 Published: 01 November 1974
Video Comment on Farzan F. Bahin et al.
Journal: Endoscopy (2015)

See also: Efficacy of viscous budesonide slurry for prevention of esophageal stricture formation after complete endoscopic mucosal resection of short-segment Barrett’s neoplasiaEndoscopy 2016; 48(01): 71-74DOI: 10.1055/s-0034-1392603
Marriages
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suggestions to Medical Writers.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regression of ocular melanoma metastatic to the liver after hepatic arterial chemoembolization with cisplatin and polyvinyl sponge
Authors: G. M. Mavligit
Journal: JAMA (1988)

Thirty patients with ocular melanoma metastatic to the liver were treated by hepatic arterial chemoembolization using an admixture of cisplatin and polyvinyl sponge. Tumor regression was complete in one patient and partial (&gt;50%) in 13 patients. The total response rate was 46%. The median survival for the entire group was 11 months (95% confidence interval, nine to 18 months). Treatmentrelated morbidity was short-lived and included primarily severe upper right quadrant abdominal pain, transient paralytic ileus, and nonicteric hepatitis. Hepatic arterial chemoembolization provided effective palliation, with goodquality survival among 46% of patients with ocular melanoma metastatic to the liver. (<i>JAMA</i>1988;260:974-976)
2-Receptor Polymorphisms in Patients Receiving Salmeterol with or without Fluticasone Propionate
Authors: E. R. Bleecker, H. S. Nelson, M. Kraft, J. Corren, D. A. Meyers, S. W. Yancey, W. H. Anderson, A. H. Emmett, H. G. Ortega
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Rationale: Retrospective pharmacogenetic studies have questioned whether patients with asthma who are arginine homozygous at the β2-adrenergic receptor (position 16) should use long-acting β-agonists.Objectives: To examine whether the response to salmeterol alone or in combination with an inhaled corticosteroid is influenced by β- receptor polymorphisms.Methods: Subjects using only as-needed albuterol were screened and completed two sequential open-label run-in periods (8 wk on as-needed albuterol; 8 wk on as-needed ipratropium). Five hundred forty-four subjects were randomized by Arg16Gly genotype to salmeterol alone or with fluticasone propionate for 16 weeks. Change from baseline in morning peak expiratory flow was the primary endpoint.Measurements and Main Results: Lung function responses were sustained over treatment and no statistically significant changes from baseline between genotypes within treatments were observed. Overall mean changes in morning peak flow for salmeterol with fluticasone propionate were 32.6 L/min (Arg/Arg vs. Gly/Gly, 95% confidence interval [CI], −6.3, 22.1), 25.9 L/min (Arg/Arg vs. Arg/Gly, 95% CI, −7.1, 21.3), and 24.9 L/min (Arg/Gly vs. Gly/Gly, 95% CI, −13.0, 14.6), and for salmeterol alone were 19.4 L/min (Arg/Arg vs. Gly/Gly, 95% CI, −1.7, 21.4), 24.6 L/min (Arg/Arg vs. Arg/Gly, 95% CI, −13.0, 10.6), and 12.4 L/min (Arg/Gly vs. Gly/Gly, 95% CI, −0.2, 22.3) for Arg/Arg, Arg/Gly, and Gly/Gly genotypes, respectively. Other measures of asthma control showed similar responses.Conclusions: The results showed no evidence of a pharmacogenetic effect of β-receptor variation on salmeterol response.Clinical trial registered with www.clinicaltrials.gov (NCT 00102882).
NERVE CONDUCTION VELOCITY
Authors: Robert Hodes
Journal: JAMA (1960)

<h3>To the Editor:—</h3> I should like to call attention to an incorrect statement in the article by Johnson and Olsen, "Clinical Value of Motor Nerve Conduction Velocity Determination," inThe Journal, April 30, page 2030. On page 2034, the authors make the following statement. "Frequently it is difficult to differentiate virus encephalomyelitis from poliomyelitis. However, measuring the nerve conduction velocity provides a very useful objective method for making the diagnosis, since the conduction velocity is normal in poliomyelitis and reduced in virus encephalomyelitis." The authors quoted one of my papers on the technique of measuring nerve conduction velocity and changes incident to traumatic damage to the nerve, but they apparently missed my subsequent work bearing directly on the sentences quoted above. I showed in a series of 26 patients that the conduction velocity in patients with poliomyelitis is indeed slower than in normal persons and, further, that the degree of
Just the Facts
Authors: Rafael Campo
Journal: New England Journal of Medicine (2004)

A patient of mine died recently, and as I dutifully filled out his death certificate beneath a sputtering fluorescent light in my hospital's admitting office, I wondered about the tales we tell in medicine and what purposes they serve. In the block print and black ink required by the form, I wrote “RESPIRATORY ARREST” and then “CHRONIC OBSTRUCTIVE PULMONARY DISEASE.” As I signed it, I felt how woefully inadequate was the summary I had just provided. Yet there were no blanks on the standard legal document for explaining the patient's chronic pain or for describing his faded tattoos or recounting . . .
Medical Social Science
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The short-term and long-term cost-effectiveness of a pedometer-based intervention in primary care: a within trial analysis and beyond-trial modelling
Authors: N Anokye, J Fox-Rushby, S Sanghera, D G Cook, S M Kerry, E Limb, C R Victor, S Iliffe, S M Shah, M Ussher, P H Whincup, U Ekelund, C Furness, J Ibison, S DeWilde, L David, E Howard, R Dale, J Smith, T J Harris
Journal: The Lancet (2016)
Oral Poliovirus Vaccine
Authors: Albert B. Sabin
Journal: JAMA (1965)

On this occasion, I have chosen a subject to which I have devoted a great part of my life. In pursuing studies on poliomyelitis since 1931, I have been motivated not only by the scientist's desire to achieve a greater understanding of natural phenomena, but also by the humanitarian's desire to eliminate a crippling disease like poliomyelitis as a source of human misery. The objective was to determine whether poliomyelitis, which has probably coexisted with human beings since earliest evolutionary times, could be eradicated in the same way that smallpox had been eradicated from many parts of the world. To achieve this it was necessary to have full intelligence of the natural history of the polioviruses, ie, where they multiplied in sufficient quantity to maintain themselves in nature, how they entered the human body, where they multiplied in the human body and how they left it, how many distinct antigenic
John Robert Murren, M.D.: In Memoriam
Authors: John Murren
Journal: Clinical Cancer Research (2006)

He distinguished himself for his clinical skills, compassion, and curiosity.He entered the laboratory in 1989, where he developed a lifelong interest in cancer pharmacology.He began by analyzing the curious relationship between neoadjuvant treatment of lung cancer and response rate, research that was notable for its probing questions and analytic approach to evaluating the existing literature.He concluded that neoadjuvant treatment of nonsmall cell lung cancer was promising, but that no rigorous study existed to prove the concept.Soon thereafter, several groups took up the gauntlet and conducted the experiments that John had recognized were lacking.He then asked why we failed to cure cancers despite a modern understanding of drug resistance mechanisms.That work led to several articles and editorials on multidrug resistance modulators.His interest in atypical multidrug resistance mediated through topoisomerases I and II led him to develop some of the earliest trials using camptothecins in small cell lung cancer.He worked with Yale's Nuclear Medicine group to develop a novel treatment for neuroendocrine tumors with radiolabeled somatostatin analogues.Since 1992, he received continuous NIH funding to study new therapies in lung cancer.In addition to his major responsibilities at Yale, John was the driving force behind the development of the nonprofit
Continuing Medical Education
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scleroderma and hyperthyroidism. Report of a case
Authors: M. Shoaleh-var
Journal: JAMA (1976)

SCLERODERMA has been reported in association with Hashimoto thyroiditis, Sjögren syndrome, congenital hypergammaglobulinemia, myasthenia gravis, mycosis fungoides, muscular dystrophy, and urticaria pigmentosa; and hyperthyroidism in association with thyroid acropachy, vitiligo, pretibial myxedema, alopecia areata, and melanoderma.<sup>1-3</sup>Even scleroderma-like thickening of extremities has been reported as a skin manifestation of hyperthyroidism,<sup>4</sup>but, to the best of our knowledge, scleroderma has not been reported in direct association with hyperthyroidism. <h3>Report of a Case</h3> A 40-year-old woman was admitted to the Khorshid Medical Center, affiliated with Isfahan University, in September 1973, complaining of palpitation, tremor of hands, dysphagia, and pain in the extremities, all of six months' duration. History disclosed pain in the joints when exposed to cold, and amenorrhea for 18 months prior to admission. On physical examination, the pulse rate was 110 beats per minute; and blood pressure, 120/75 mm Hg. Temperature was normal. The patient had exophthalmos, with
Assessment of ocular protection for racquetball
Authors: M. J. Feigelman
Journal: JAMA (1983)

We evaluated the ability of 11 commercially available eye guards (lensless and closed) and eight piano spectacles (varying in lens thickness and material) to prevent ocular trauma from racquetballs. A guard was judged to be effective if the lens or frame did not shatter or dislodge after a minimum of ten direct blows with a racquetball and if eye contact was prevented. All spectacles failed; either the lens or the frame shattered. Open eye guards permitted the ball to contact the eye or were themselves propelled into the eye. Three commercially available closed guards failed because their frames broke. Only four guards passed our criteria for effectiveness. (<i>JAMA</i>1983;250:3305-3309)
Overtreatment?
Authors: S L Baldeweg
Journal: BMJ (2005)

Overall, 35 of the 150 units that responded (23%) did not provide an emergency out of hours endoscopy service.In the 115 (77%) units that did, this was provided by a median of five consultants and featured junior endoscopists in 47 units, acting independently in 15.Forty one units reported having an ad hoc or goodwill rota rather than a formal on-call arrangement.Out of hours procedures were done in the endoscopy department in 61 units, in theatre in 43 units, and on the ward for the remainder.Trained endoscopy staff helped the endoscopist in 49 units.Theatre staff support was needed in 47 units and ward staff in 15 units.Larger units tended to do the endoscopies in the endoscopy department, but there was no variation in location or staffing for units of smaller sizes (table ).A mean of 90.2 (95% confidence interval 72.0 to 108.5) emergency endoscopies per 100 000 population were done each year for upper gastrointestinal bleeding, of which 26.7 were out of hours.Although larger units (including tertiary centres) received more patients with gastrointestinal bleeding and did more out of hours procedures this was not significant.
A Psychiatric Change in Accident Victims
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Symposium: Natural Immunity and Biological Response Modification for the Therapy of Cancer and Other Diseases
Journal: JNCI Journal of the National Cancer Institute (1985)

International Symposium: Natural Immunity and Biological Response Modification for the Therapy of Cancer and Other Diseases Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 2, August 1985, Pages 395–396, https://doi.org/10.1093/jnci/75.2.395-d Published: 01 August 1985
BOOK REVIEWS
Authors: S. SHACKNEY
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Effects of Tlherapy on Biology and Kinetics of the Residual Tumor, Part B: Clinical Asoects—Progress in Clinical and Biological Research, Volume 354B . Joseph Ragaz , Linda Simpson-Herren , Marc E. Lippman , Bernard Fisher , eds. New York : Wiley-Liss, Inc. , 1990 , 264 pp. $89.95. STANLEY SHACKNEY, M.D. STANLEY SHACKNEY, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 15, 7 August 1991, Pages 1105–1106, https://doi.org/10.1093/jnci/83.15.1105-a Published: 07 August 1991