tbuckley/cabot-search huggingface dataset:
Health Effects of Metals: A Role for Evolution?
Authors: Tom Clarkson
Journal: Environmental Health Perspectives (1995)

Metals have been mined and used since ancient times.The industrial era has seen a sharp increase in both the amounts and variety of metals that find applications in industry.The inadvertent release of metals, such as from fossil fuel consumption, also adds to the global burden.A number of catastrophic outbreaks have alerted us to the occupational and environmental health risks.Life on this planet has evolved in the presence of metals.Cells learned to make use of the more abundant metals in the Archean oceans as an integral component in their structure and function.Today, we inherit these as the essential metals.At the same time, evolving life must have developed means of coping with the potentially toxic actions of met- als.The appearance of oxygen in the atmosphere in the Precambrian period also resulted in cells both using and developing protective mechanisms against what must have been a highly toxic, reactive gas.Atmospheric oxygen must have increased the solubility of many metals as insoluble metal sulfides were oxidized to the more soluble sulfates.It may be no coincidence that the protective mechanisms for oxygen are also used to protect against a number of toxic metals.Selected examples are given on the role of evolution in metal toxicology, specifically, examples where the normal function of essential metals is deranged by competition with nonessential metals.Examples are also given of protective mechanisms that involve enzymes or cofactors involved in the oxygen defense system.
Metal Mutagenesis in Transgenic Chinese Hamster Cell Lines
Authors: Catherine B. Klein, Biserka Kargacin, Lin Su, Sofia Cosentino, Elizabeth T. Snow, Max Costa
Journal: Environmental Health Perspectives (1994)

Metals are toxic agents for which genotoxic effects are often difficult to demonstrate.To study metal mutagenesis, we have used two stable hprt gpte transgenic cell lines that were derived from Chinese hamster V79 cells.Both the G12 and Gl0 cell lines are known to be very sensitive to clas- togens such as X-rays and bleomycin, with the mutagenic response of the integrated xanthine guanine phosphoribosyl transferase (gp) gene in G10 usually exceeding that of the same gene in the transgenic G12 cells.In studies with carcinogenic insoluble nickel compounds, a high level of muta- genesis was found at the gpt locus of G12 cells but not at the endogenous hypoxanthine phosphoribosyl transferase (hpr locus of V79 cells.We have since demonstrated the similar recovery of a high frequency of viable G12 mutants with other insoluble nickel salts including nickel oxides (black and green).The relative mutant yield for the insoluble nickel compounds (G1 2>G1 0) is the opposite of that obtained with nonmetal clastogens (G10>G12).In the G12 cells, nickel mutagenesis may be related to the integration of the gpt sequence into a heterochromatic region of the genome.For some of the insoluble nickel compounds, significant inhibition of both cytotoxicity and mutant yield resulted when the G12 cells were pretreated with vitamin E. In comparison with the nickel studies, the mutagenic responses to chromium compounds in these cell lines were not as dramatic.Mutagenesis of the gpt target could not be demonstrated with other metals such as mercury or vanadium.-
West Nile Virus Infection in Organ Donor and Transplant Recipients—Georgia and Florida, 2002
Journal: JAMA (2002)

On August 23, 2002, the Georgia Division of Public Health (GDPH) and CDC were notified of two cases of unexplained fever and encephalitis in recipients of organ transplants from a common donor. An investigation has identified illness in two other recipients from the same donor: one with encephalopathy and the other with febrile illness. CDC, the Food and Drug Administration, GDPH, and the Florida Department of Health are conducting the investigation. This duster could possibly represent the first recognized transmission of West Nile virus (WNV) by organ donation.
Distancing
Authors: Maryella Sirmon
Journal: Annals of Internal Medicine (2020)

Ad Libitum16 June 2020DistancingFREEMaryella Sirmon, MDMaryella Sirmon, MDUniversity of South Alabama, Mobile, Alabama (M.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-1711 Audio Reading - “Distancing” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Distancing” by Maryella Sirmon, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Virus Log: Day 4.7.2020 Contagion came, I locked my doornot wanting to make this acquaintance. Inside—I am restless, annoyed. A pestilenceof fear writhes like earthworms seeking soil. Night around me sleeps, but I cannot,so I rise from fretful dreams. Bare feet pad across wide wood planks of my bedroom floor,searching for pen and paper and reassurance. Uncertainty an old friend, this a different doubt.Grief binding days in an unnamed procession, dark anticipation of what will be across the world,lamenting what is and what is no longer. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: University of South Alabama, Mobile, Alabama (M.S.)Current Author Address: Maryella Sirmon, MD; e-mail, [email protected]com.This article was published at Annals.org on 21 April 2020. PreviousarticleNextarticle Advertisement Audio Reading - “Distancing” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Distancing” by Maryella Sirmon, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 16 June 2020Volume 172, Issue 12Page: 844KeywordsFearSleep ePublished: 28 April 2020 Issue Published: 16 June 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
T cell receptor repertoire of infiltrating T cells in lips of Sjögren's syndrome patients
Journal: Journal of Clinical Investigation (1992)

The text in the right-hand column, lines 31-34, should read:For quantitation of the TCR Vfl and Co gene transcripts, PCR products were hybridized with the 32P-labeled PstI fragment of the JUR-32 gene (9) (CO) and the intensities of the autoradiographic bands were quantitated by densitometer (Fujix BAS 2000; Fujifilm I&I Co.).
Retraction: Haploinsufficiency of the <i>Hmga1</i> Gene Causes Cardiac Hypertrophy and Myelo-Lymphoproliferative Disorders in Mice
Authors: Monica Fedele, Vincenzo Fidanza, Sabrina Battista, Francesca Pentimalli, Andres J.P. Klein-Szanto, Rosa Visone, Ivana De Martino, Antonio Curcio, Carmine Morisco, Luigi Del Vecchio, Gustavo Baldassarre, Claudio Arra, Giuseppe Viglietto, Ciro Indolfi, Carlo M. Croce, Alfredo Fusco
Journal: Cancer Research (2018)
HIV Risk From Oral Sex Higher Than Many Realize
Authors: J. Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Care in Modern Warfare
Journal: New England Journal of Medicine (1982)

WE welcome this opportunity to express our view of the CMCHS, the plan recently developed by the Department of Defense to enlist civilian hospitals in a voluntary commitment of beds to provide care for military casualties from a future large-scale war overseas.Our organization, Physicians for Social Responsibility, is deeply committed to the task of meeting the health-care needs of our nation. In a time of war or national emergency, it is our highest priority to provide medical assistance to troops in combat. In these times of relative peace, our organization has devoted its attention to educating the medical community . . .
Atrioventricular block induced by swallowing in a patient with diffuse esophageal spasm
Authors: M. Bortolotti
Journal: JAMA (1982)

A patient had syncope induced by swallowing. Electrocardiographic monitoring during eating and esophageal balloon inflation demonstrated a second-degree atrioventricular block (Mobitz type II) with dizziness. Radiologic and manometric examinations of the esophagus showed diffuse esophageal spasm associated with hypertension of the upper esophageal sphincter (UES), gastroesophageal reflux, and a sliding hiatal hernia. Cineradiographic observations were made during ingestion of a meal mixed with barium; at the time of cardiac dysrhythmia, the proximal part of the esophagus containing the bolus assumed a balloonlike shape, while the distal part and the UES contracted. On the basis of these observations and review of all published cases, we propose the pathways of this esophagocardiac reflex and discuss up-to-date treatment. (<i>JAMA</i>1982;248:2297-2299)
Diphtheria, Tetanus, and Pertussis: Guidelines for Vaccine Prophylaxis and Other Preventive Measures
Authors: CENTERS FOR DISEASE CONTROL, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Journal: Annals of Internal Medicine (1985)

This revision of the Immunization Practices Advisory Committee (ACIP) statement on diphtheria, tetanus, and pertussis updates the statement issued in 1981 and incorporates the 1984 supplementary statement on the risks of pertussis disease and pertussis vaccine for infants and children with personal histories of convulsions. It includes a review of the epidemiology of the three diseases, a description of the available immunobiologic preparations, and the appropriate immunization schedules. Also included are revisions in the schedule for combined diphtheria and tetanus toxoids, when pertussis vaccine is contraindicated, and revisions in the recommendations on precautions and contraindications to vaccine use, on immunization for infants and children who have underlying neurologic disorders, and on tetanus prophylaxis in wound management.
Thymosin alpha 1 for patients with hepatitis B virus-related acute-on-chronic liver falure: a randomized controlled trial
Authors: Jun-Feng Chen, Shu-Ru Chen, Zi-ying Lei, Hui-Juan Cao, Shao-Quan Zhang, Weizhen Weng, Jing Xiong, Wenxiong Xu, Ka Zhang, Zhiliang Gao, Bingliang Lin
Journal: Journal of Hepatology (2020)
Cor pulmonale due to pulmonary fibrosis simulating mediastinal tumor
Authors: I. Steinberg
Journal: JAMA (1967)

RARELY, enlarged pulmonary arteries due to cor pulmonale may be mistaken for hilar and mediastinal neoplastic masses. Herein are reported the cases of two women: one with pulmonary fibrosis, of unknown etiology, resembling the Hamman-Rich syndrome; the other with cor pulmonale secondary to an unsuspected lipoid pneumonia. In both cases, angiocardiography, by visualizing the cardiovascular structures, demonstrated the enlarged pulmonary artery and branches, suggested the diagnosis of cor pulmonale, and excluded the diagnosis of hilar and mediastinal neoplasm.<sup>1</sup> <h3>Report of Cases</h3><h3>Case 1.—</h3> A 43-year-old woman was admitted to the hospital on Sept 8, 1964, with complaint of dyspnea. She had been in good health until two years prior to admission when a routine roentgenogram of the chest showed bilateral upper-lobe pulmonary infiltrates. Although acidfast bacilli were not found in the sputum, she was treated with antituberculous drugs for five months. Ten months prior to admission she was exposed
Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes
Authors: I. B. Wilson
Journal: JAMA (1995)

HEALTH-related quality of life (HRQL) is increasingly used as an outcome in clinical trials, effectiveness research, and research on quality of care. Factors that have facilitated this increased usage include the accumulating evidence that measures of HRQL are valid and "reliable,"<sup>1</sup>the publication of several large clinical trials showing that these outcome measures are responsive to important clinical changes,<sup>2-5</sup>and the successful development and testing of shorter instruments that are easier to understand and administer.<sup>6-13</sup>Because these measures describe or characterize what the patient has experienced as the result of medical care, they are useful and important supplements to traditional physiological or biological measures of health status. Given this improved ability to assess patients' health status, how can physicians and health care systems intervene to improve HRQL? Implicit in the use of measures of HRQL in clinical trials and in effectiveness research is the concept that clinical
Block That Kick in the Teeth
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of FIB-4 score with disease progression in real-world populations diagnosed with NAFLD/NASH or at risk of NASH in US clinical practice
Authors: Michelle Lai, Jeremy Broestl, Andrew Frick, Richard Haubrich, Bruce Koch, Scott Milligan, Macky Natha, Zobair Younossi, Nezam Afdhal
Journal: Journal of Hepatology (2020)
<i>Gondoskodás As Elmebetegekröl Mis Allambokman És Nálunk.</i> Iota Dr. Pandy Kálmán, Kórháze fóorvas. XXXVIII. Táblával. (Gyulan; Nértesi Arnold Corvina, Könyvnomdája, 1905.) (<i>The Care of the Insane in Foreign Countries and in Our Own.</i> By Dr. Kalman Pandy, Chief Physician of the Hospital Gyula (Hungary), 1905.)
Journal: American Journal of Psychiatry (1906)
When Patients Are Close-Lipped About Memory Problems
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Circulation (2008)

a number of errors occurred.These erros have been corrected in the current online version of the article.In Tables 1 through 5, numerous errors occurred in shadings (added to enable gene cross referencing), formatting, use of special symbols, and footnotes.Additionally, references have been added to the body of Table 3.In Table 5, middle panel, second-to-last row, the up arrow should be replaced by a down arrow, and in the bottom row, a reference should be added.The publisher regrets these errors.Throughout the article, the A-kinase-anchoring protein gene AKAP9 gene was mistakenly omitted from discussions of long-QT Syndrome-susceptibility genes.The gene has been added to the text where relevant and Tables 2 and3 have been updated to include the gene.Also, an article presenting important findings about the gene (Chen L, Marquardt ML, Tester DJ, Sampson KJ, Ackerman MJ, Kass RS.Mutation of an A-kinase-anchoring protein causes long-QT syndrome.
Olaratumab for STS Disappoints in Phase III
Journal: Cancer Discovery (2019)

Abstract Two years after receiving accelerated approval from the FDA as first-line therapy with doxorubicin for patients with advanced or inoperable soft-tissue sarcoma, the anti-PDGFRα antibody olaratumab's potential has not held up in a required phase III study. The combination yielded no significant difference in median overall survival compared with doxorubicin alone, prompting the company to stop promoting olaratumab.
Retinal Tear After Teeth Cleaning
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Audit and inflammatory bowel disease
Authors: A Carmichael, Sue-Ling Dj Owen, D Johnston, S White, J Hart, A Torrance, S Clark, P Bottrill, K Matthewson
Journal: Gut (1996)

Coronary heart disease (CHD) is the commonest cause of death in the western world.The increasing incidence of obesity poses a serious risk of CHD because of its effects on serum lipids, type II diabetes, hypertension and left ventricular hypertrophy.The Framingham group have devised a CHD score based on a 40 year follow-up of over 5000 men and women.It is robust and validated to predict the risk that CHD will develop in the ensuing 10 years.The Magenstrasse and Mill procedure for morbid obesity involves formation of a lesser curve tube of the stomach connected to normal antral mill and is more physiological than other anti-obesity procedures.We tested the hypothesis the M&M procedure would provide good protection against the risk of CHD, which is greatly increased in obese people.The Framingham risk score based on patients' age, gender, lipids, cigarette smoking, ECG-LVH, blood pressure and diabetes was used to measure the risk of CHD in 24 obese patients,(23 females) with a median age of 40 years (range 31-48), before and 24 months after the M&M procedure for morbid obesity.The Framingham score, median (range) was reduced from 9 (3-29) to 3(1-7) with a median percentage reduction of 67%( P < 0.001).Weight was reduced from 137kg (127-200) to 91kg(62-114) with a median 58% reduction in excess body weight.Median BMI was reduced from 51(36-61) to 34(27-41) kg/in2.NIDDM was"cured' in all 8 patients while impaired glucose tolerance reverted to normal in a further 3 patients.Five of eight hypertensive patients (SB.P > 160) came off anti-hypertensive medication and their blood pressure reverted to normal.Thus, the M&M procedure led to a significant reduction both in weight and the risk of CHD in morbidly obese patients.