tbuckley/cabot-search huggingface dataset:
SAT0061 Prevalence of Co-Morbidities in Rheumatoid Arthritis (RA) and Evaluation of their Monitoring: Results of an International, Cross-Sectional Study (Comora)
Authors: M. Dougados, M. Soubrier, A. Antunez, P. Balint, A. Balsa, M. Buch, G. Casado, J. Detert, B. El-Zorkany, P. Emery, N. Hajjaj-Hassouni, M. Harigai, J. Kay, S.-F. Luo, R. Kurucz, G. Maciel, E. Martin Mola, C. M. Montecucco, I. Mc Innes, H. Radner, J. Smolen, Y.-W. Song, M. Van de Laar, K. Winthrop
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Increased risk of cardio-vascular disease, infection and osteoporosis is well documented in RA. Some of these co-morbidities (e.g. cardiovascular disease risk) are subject to recommendations, with specific components relevant to RA. It is unclear whether such co-morbidity is recognized, or whether recommendations are applied in practice. <h3>Objectives</h3> To evaluate: 1) the prevalence of RA co-morbidities in different countries worldwide and 2) the gap between available recommendations and daily practice concerning prevention/management of such co-morbidities. <h3>Methods</h3> International, cross-sectional study of consecutive RA patients in routine care. Data comprise RA characteristics, plus relevant cardiovascular, infection, cancer, gastro-intestinal pulmonary, psychiatric disorders. <h3>Results</h3> Seventeen participating countries (from 4 continents) included 4586 patients. Age: 56+13 years, disease duration: 10+9 years, female gender: 82%, DAS28-ESR: 3.7 + 1.6, HAQ1.0+0.7, any past or current intake of methotrexate (98%), of biotherapy (39%). The most frequent coincident diseases (past or current) were depression: 15%, asthma 6.6%, cardiovascular events (myocardial infarction, stroke) 6%, solid cancer (excluding basocellular carcinoma) 4.5%, and chronic obstructive pulmonary disease 3.5%. Substantial inter-country variability was observed both for prevalence of co-morbidities or coincident conditions [(e.g.% smokers from 3% (Morocco) to 48% (Austria), % with hepatitis (from 0% (France) to 7% (Egypt)] and also for the prevention/management of co-morbidities (e.g. pneumococcal vaccination from 0% (Netherlands) to 87% (Germany). Critically, systematic evaluation of co-morbidities permitted detection of previously undetected abnormalities [e.g. elevated blood pressure (11.2%), hyperglycemia (5.8%)] and serving to emphasise the sub-optimal management of such co-morbidities (e.g. of 236 patients with a history of cardiovascular events, 74 (32%) were not on anti-thrombotic therapy). <h3>Conclusions</h3> This study suggests a) high prevalence of co-morbidities in RA, b) substantial inter-country variability c) variable detection of relevant risk factors and application of preventive strategies (e.g. vaccination). The study strongly suggests that rigorous application of systematic evaluation of co-morbidities could permit earlier detection and disciplined management with attendant improvement in outcomes in RA. <h3>Acknowledgements</h3> This study was conducted thanks to an unrestricted grant from Roche Ltd <h3>Disclosure of Interest</h3> None Declared
Physician Suicide
Authors: John J. Dempsey
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The most distressing aspect of the recent COUNCIL REPORT by the Council on Scientific Affairs<sup>1</sup>entitled "Results and Implications of the AMA-APA Physician Mortality Project" doesn't relate to the statistics of the 142 suicide cases but rather to those associated with the "controls." People, physicians or otherwise, who kill themselves are obviously distraught. We shouldn't be surprised that one out of five of them had a history of drinking to the point of unconsciousness, that over one third of them had a history of drug abuse, and that over one third had beaten their wives. Those are painful statistics, but they were obtained on desperate people. The statistics given on the controls are more worrisome if we are to assume that "control" is a synonym for "normal." Are we to accept, for example, that one out of nine physicians beats his wife? Who among us thinks that
Intersexuality
Authors: George W. Corner
Journal: JAMA (1964)

This is the second comprehensive book to be published in English on this once esoteric subject. Much of the mystery surrounding intersexuality has been dispelled by recent developments such as nuclear sexing, accurate chromosome analysis, and new discoveries in embryology and endocrinology. It now appears that at least 2% of the world's population suffers from some degree of intersexual defects. Thus, ribald curiosity has given way to serious study. The current volume is a translation of<i>Die Intersexualität</i>, originally published in Germany in 1961. An attempt has been made to bring it up to date by adding newer information and references to some of the chapters. Although it is claimed that the various authors are internationally recognized experts, 10 of the eighteen authors are Germans and only Barr, Ford, Davidson, Lennox, Witschi, and Zander have a truly international reputation. The translations, however, are excellent and the authors write from a
Serum-based Metabolomics-Advanced StEatohepatitis Fibrosis Score (MASEF) fot the non-invasive identification of patients with non-alcoholic steatohepatitis with significant fibrosis
Authors: Mazen Noureddin, Rebeca Mayo, Ibon Martínez-Arranz, Itziar Mincholé, Jesus Maria Banales, Pedro Miguel Rodrigues, Javier Crespo, Luca Valenti, Libor Vitek, Maha Guindi, Manuel Romero Gomez, Cristina Alonso, Paula Iruzubieta, Fernando Bril, Ortiz Pablo, Radan Bruha, Marco Arrese, Jean-François Dufour, Kenneth Cusi, Quentin Anstee, José M. Mato, Arun Sanyal
Journal: Journal of Hepatology (2020)
Nafcillin-induced interstitial nephritis
Authors: T. W. Bodendorfer
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Acute interstitial nephritis caused by any drug is probably a rare drug reaction. Methicillin sodium is the most commonly reported penicillin derivative associated with nephritis, with more than 100 cases being reported.<sup>1</sup>Reexacerbation (ie, cross sensitivity) with nafcillin, ampicillin, and cephalothin administration has been reported (1973;225: 178; 1974;227:255).<sup>2</sup>Although histological confirmation was not obtained, this is a probable case of nafcillininduced interstitial nephritis. <h3>Report of a Case.—</h3> A 60-year-old man was admitted to the orthopedic unit of Memorial Hospital Medical Center with a painful swollen right knee. He had a 40-year history of hypertension, rheumatoid arthritis, and coronary artery disease, but no renal disease. Therapy with indomethacin, 100 mg/24 hr, and allopurinol, 200 mg/24 hr, was started. Medicationscontinued from before admission included propranolol hydrochloride, 160 mg/24 hr, isosorbide dinitrate, 160 mg/24 hr, and nitroglycerin as needed. On the second day of hospitalization, knee aspirate
2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) as a Potent and Persistent Thyroxine Agonist: A Mechanistic Model for Toxicity Based on Molecular Reactivity
Authors: J. D. McKinney, J. Fawkes, S. Jordan, K. Chae, S. Oatley, R. E. Coleman, W. Briner
Journal: Environmental Health Perspectives (1985)

TCDD and thyroxine have common molecular reactivity properties which enable them to present a planar face and lateral halogens in interactions with proteins. These molecular properties are consistent with the structure-toxicity relationship for TCDD and related compounds. Biological evidence is discussed including preliminary studies on the effects of TCDD exposure on tadpole growth and development which is consistent with the possible thyroxine-like activity of TCDD. The work suggests the possibility that toxicity is at least in part the expression of potent and persistent thyroid hormone activity (responses induced by TCDD which qualitatively correspond to those mediated by thyroid hormones). A mechanism for toxicity is proposed which involves receptor proteins; the planar aromatic system controls binding to cytosolic proteins and halogen substituents regulate binding to nuclear proteins. This simple model based on molecular reactivity sheds light on the diversified effects of TCDD and related compound toxicity and on certain thyroid hormone action. The model also permits predictions to be made with regard to the toxicity and thyroid hormone activity of untested compounds. In addition, the model suggests a general mechanism for hormone action based on metabolically regulated differential and cooperative protein receptor binding events in cellular compartments which can explain agonism, antagonism and potentiation within the framework of receptor occupancy theory.
Pediatrics
Authors: Howard A. Pearson
Journal: JAMA (1994)

As late as the 1980s, serious invasive diseases caused by<i>Haemophilus influenzae</i>type b (Hib), chiefly meningitis and epiglottitis, were important causes of morbidity and mortality in children, especially in infants younger than 15 months. The mortality associated with Hib meningitis was 3% to 6%, and permanent neurological sequelae occurred in 20% to 30% of survivors. This degree of morbidity and mortality was comparable to that observed during the last great epidemics of paralytic poliomyelitis during the 1950s. The first vaccines active against Hib disease were prepared from the Hib capsular polysaccharide polyribosylribitol phosphate (PRP) and introduced in the 1980s. These Hib PRP vaccines were immunogenic and clinically effective in children older than 18 months. However, they elicited little antibody response in infants aged 3 to 17 months, and two thirds of serious invasive Hib disease occurs in infants younger than 18 months. Despite this, in 1985 PRP vaccine administration
Stem Cells in <i>Circulation</i> and the <i>Circulation</i> Subspecialty Journals
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the articles related to stem cells that were published in Circulation and the Circulation subspecialty journals in 2010 and 2011.
Expression of the Human Germinal Center-Associated Lymphoma (HGAL) Protein, a New Marker of Germinal Center B Cell Derivation.
Authors: Yasodha Natkunam, Izidore S. Lossos, Behnaz Taidi, Shuchun Zhao, XiaoQing Lu, Feying Ding, Anne S. Hammer, Teresa Marafioti, Gerald E. Byrne, Shoshana Levy, Roger A. Warnke, Ronald Levy
Journal: Blood (2004)
Highlights
Journal: JAMA Internal Medicine (2018)

Reduction of IV Opioids in Medical Patients 759For this observational study, Ackerman and colleagues evaluated an intervention to reduce opioid exposure by switching from intravenous (IV) to oral or subcutaneous administration in medical inpatients.Over a total of 2459 patient-days, IV opioid dosing was reduced by 84%, with mean pain scores similar to those before implementation of the new standard, demonstrating that this intervention targeting the use of IV opioids may be associated with reduced opioid exposure while providing effective pain control to hospitalized adults.Related Articles 764 and 861 Buprenorphine for Treatment of Opioid Use Disorder 764For this randomized clinical trial, Lofwall and colleagues examined whether treatment involving novel weekly and monthly subcutaneous buprenorphine depot formulations is noninferior to a daily sublingual combination of buprenorphine hydrochloride and naloxone hydrochloride in the treatment of opioid use disorder.Results showed that compared with daily sublingual buprenorphine, sustained-release subcutaneous buprenorphine did not result in an inferior likelihood of being a responder or having urine test results negative for opioids and produced superior results on the cumulative distribution function of no illicit opioid use.
Single-dose therapy for cystitis
Authors: S. A. Lerner
Journal: JAMA (1982)

Cystitis afflicts about 20% of women at least once in their lifetime.<sup>1</sup>Although this infection is generally treated with antibiotics, in some cases it may resolve spontaneously.<sup>2</sup>Therefore, courses of antimicrobial treatment shorter than the conventional seven to ten days, down to a single dose, have been investigated as a means of reducing the cost and side effects of treatment of this common infection. In this issue ofThe Journal(p 1839), Buckwold and co-workers extend a series of studies that report high rates of cure of urinary tract infection in women treated with single doses of antimicrobial agents that are excreted and concentrated in urine. Despite the ease of clearing of bacteria from the urine initially with antimicrobial therapy to which the infecting pathogen is susceptible, some women are prone to relapse after single-dose treatment, or even after conventional therapy.<sup>3</sup>The current study and some of the
The Healing Touch
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-065 Targeted inhibition of tissue factor and thrombin on CD31 expressing cells suppresses hepatic fibrosis in CCl4 treated mice
Authors: G Petts, A Dhar, H Kudo, F Sadiq, Q Anstee, Y Kallis, A Dorling, R Goldin, M Thursz
Journal: Gut (2012)

<h3>Introduction</h3> Recent evidence suggests a role for the coagulation cascade in promoting liver fibrosis. However, the cellular basis for this relationship is unclear. In order to explore this relationship we employed two unique transgenic mice strains expressing membrane–tethered tissue factor pathway inhibitor (TFPI) or hirudin (anti-thrombin) fusion proteins driven by a CD31 promoter. These strains allow for the selective inhibition of tissue factor (TF) or thrombin on endothelial cells, monocytes and platelets expressing CD31. <h3>Aims</h3> To evaluate the impact of the targeted inhibition of tissue factor and thrombin on effector cells of liver fibrosis in murine hepatic fibrosis induced by CCl<sub>4</sub>. <h3>Methods</h3> Liver fibrosis was induced in CD31-TFPI, CD31-Hirudin and wild type control mice with 4 weeks carbon tetrachloride (CCl<sub>4</sub>) administered by intraperitoneal injection. Animals were culled and livers extracted for histological and biochemical analysis. Fibrosis was scored using a four point semi-quantitative system and quantified by digital image analysis to determine percentage area of fibrosis. Immunohistochemistry to determine α-SMA expression, a marker of hepatic stellate cell activation was performed and the mean number of activated stellate cells was quantified per high power field. <h3>Results</h3> The percentage area of fibrosis was significantly less in CD31-TFPI (1.89%±0.26, p=0.001) and CD31-Hirudin mice (1.04%±0.16, p=0.00003) in comparison to control mice (3.66%±0.39). Semiquantitative fibrosis scoring showed a significant difference between the CD31-TFPI (median 2/4) and CD31-Hirudin (median 3/4) mice in comparison with control mice (median 3/4, p=0.009) but the difference between the two transgenic strains was not significant. Both transgenic strains demonstrated a significantly reduced mean number of α-SMA stellate cells per high power field in comparison to control mice (CD31-TFPI vs control, 7.4 vs 29.4, p=0.0002; CD31-hirudin vs control, 5.25 vs 29.4, p=0.0002). <h3>Conclusion</h3> CD31 targeted inhibition of TF and thrombin significantly reduces liver fibrosis and stellate cell activation in a murine CCl<sub>4</sub> model. The data supports the use of this novel murine model as a tool for investigating the cellular biology of the role of coagulation in liver fibrogenesis. It will also provide information for developing new treatments of human liver fibrosis. <h3>Competing interests</h3> None declared.
The radionuclide ventriculogram
Authors: S. M. Larson
Journal: JAMA (1973)

Radionuclide ventriculography is a safe and effective method for evaluating cerebrospinal fluid (CSF) dynamics. Seventy radionuclide ventriculograms from 47 patients were reviewed. The patients were primarily adults with acquired disorders, such as intracerebral neoplasm, meningeal infection, and low pressure hydrocephalus. Proper interpretation depended on an understanding of ventricular anatomy and the usual sequence of CSF flow. Important applications were assessment of CSF shunts, determination of the distribution of intrathecally administered drugs, evaluation of the functional status of hydrocephalus, and assessment of the progression of neoplastic invasion of the ventricular system.
Correction
Journal: BMJ (1953)

ANY QUESTIONS?MEDICALTJISOHRN nerve tissues are insensitive to radiation and unlikely to be damaged under ordinary therapeutic conditions.In the absence of evidence of visceral or osseous damage, persis- tent severe pain after radiotherapy usually means that neoplasm is present-somewhere.In such cases the mea- sures available for relief of pain are: analgesics (a mixture containing aspirin, phenacetin, and caffeine with 20 minims (1.2 ml.) of " nepenthe" is often very helpful); epidural alcohol injections; and cordotomy.
Propylthiouracil-Induced Cutaneous Vasculitis
Authors: David B. Vasily
Journal: JAMA (1980)

A patient had cutaneous vasculitis, leukopenia, and splenomegaly caused by the antithyroid drug, propylthiouracil. Histopathologic changes of acute vasculitis of the superficial and deep dermal blood vessels accompanied by fibrin thrombi formation were found in biopsy specimens of the cutaneous lesions. Direct immunofluorescence studies demonstrated IgM and C3 of the vessel walls suggesting immune complex deposition. The literature disclosed five cases with similar features associated with propylthiouracil therapy. Characteristic cutaneous findings include a recurrent, self-limited, symmetrical purpuric eruption that can involve the face or earlobes. Clinicians should recognize these changes as a cutaneous sign of a vasculitis associated with propylthiouracil therapy. (<i>JAMA</i>243:458-461, 1980)
Update: Influenza Activity--United States and Worldwide, June-September, 2002
Journal: JAMA (2002)

During June-September 2002, influenza A (H3N2) and B viruses circulated worldwide and were associated with mild to moderate levels of disease activity. Influenza B viruses predominated in Africa, and both influenza A (H3N2) and B viruses circulated widely in Asia, Oceania, and Latin America, except in Chile and Taiwan, where A (H1) viruses predominated. In North America, sporadic isolates of influenza A (H3N2), A (H1), and B viruses were identified. This report summarizes influenza activity in the United States and worldwide during June-September 2002. Influenza activity in North America typically peaks during December-March, which underscores the need to begin vaccinating against influenza in October and to continue vaccination into December and throughout the influenza season.
Update: Prevalence of Overweight Among Children, Adolescents, and Adults—United States, 1988-1994
Journal: JAMA (1997)

Overweight and obese adults are at increased risk for morbidity and mortality associated with many acute and chronic medical conditions, including hypertension, dyslipidemia, coronary heart disease, diabetes mellitus, gallbladder disease, respiratory disease, some types of cancer, gout, and arthritis. In addition, overweight during childhood and adolescence is associated with overweight during adulthood, and previous reports have documented an increase in the prevalence of overweight among children, adolescents, and adults from 1976-1980 to 1988-1991. This report presents data from CDC's Third National Health and Nutrition Examination Survey (NHANES III) (1988-1994) to provide the most recent national estimates of overweight among children (ages 6-11 years), adolescents (aged 12-17 years), and adults (aged > or = 20 years) in the United States. The findings indicate that the prevalence of overweight in the United States has continued to increase.
ANOTHER DEATH FROM CHLOROFORM.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-351 Early vascular responses to everolimus-eluting cobalt-chromium stent for the treatment of ST-elevation acute myocardial infarction: the results of the MECHANISM-AMI Study 2-week OCT follow-up cohort
Authors: Yoshihiro Morino, Daisuke Terashita, Hiromasa Otake, Tatsuo Kikuchi, Tetsuya Fusazaki, Nehiro Kuriyama, Takahide Suzuki, Toshiya Muramatsu, Kiyoshi Hibi, Hiroyuki Tanaka, Shozo Ishihara, Toru Kataoka, Takayuki Okamura, Takashi Morita, Yoritaka Otsuka, Takatoshi Hayashi, Kengo Tanabe, Toshiro Shinke
Journal: Journal of the American College of Cardiology (2015)