tbuckley/cabot-search huggingface dataset:
DISEASES OF THE PINEAL BODY.
Journal: JAMA (1900)

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Outcomes for advanced HER2 positive gastroesophageal cancer by anatomical location: Experience from the Princess Margaret Cancer Centre.
Authors: Charles Henry Lim, Daniel Yokom, Di Maria Jiang, Lucy Xiaolu Ma, Peiran Sun, Hao-Wen Sim, Akina Natori, Bryan Anthony Chan, Stephanie Moignard, Jennifer J. Knox, Eric Xueyu Chen, Geoffrey Liu, Carol Jane Swallow, Gail Elizabeth Darling, Savtaj Singh Brar, Sara Hafezi-Bakhtiari, James Conner, Elena Elimova, Raymond Woo-Jun Jang
Journal: Journal of Clinical Oncology (2018)

e16069 Background: The landmark ToGA trial established trastuzumab (T) based therapy as the standard of care for advanced HER2+ gastric and gastroesophageal junction cancer. However, outcomes for T based therapy for HER2+ esophageal cancer have not been well characterized. Methods: We conducted a retrospective analysis of patients (pts) with HER2+ gastroesophageal cancer receiving T based therapy at our institution from 2011-2016. Distal esophagus ( < 35 cm) and Siewert type I/II tumours were defined as esophageal (E). Siewert type III and stomach tumours were defined as gastric (G). Trained abstractors collected pt demographics and treatment details. Overall survival (OS) and progression-free survival (PFS) were calculated from the date of first T treatment. Chi-square tests, t-tests and Cox proportional hazards models were applied where appropriate. Results: We identified 87 pts with advanced HER2+ disease. 62% (n = 54) had de novo metastatic (M1) disease. 57 patients were treated with T based therapy, with median age 57 years (IQR 48-67), 91% baseline performance status 0-1, 19% female, and 7% Asian. 63% (n = 36) had E and 37% (n = 21) had G primary tumours. 67% (n = 38) presented with M1 disease. 33% (n = 19) underwent surgery with curative intent and received T based therapy at recurrence. Baseline characteristics were balanced between the E and G groups. Survival data were available for 51 patients. The E and G groups did not have significant differences in PFS (median 9.5 vs. 9.1 months, HR 0.89 (95% CI 0.44-1.80), p = 0.74) or in OS (median 15.8 vs. 14.2 months, HR 0.88 (95% CI 0.42-1.82), p = 0.73). 63% (n = 36) were treated with subsequent systemic therapy after progression on T, with 23 receiving one line, 9 receiving two lines and 4 receiving three additional lines of treatment. The number of subsequent therapies received was similar between E and G groups. Conclusions: Although patients with distal esophagus tumours were not included in the ToGA trial, our analysis suggests that patients with E and G tumours had similar outcomes. Our contemporary cohort had comparable survival outcomes relative to patients receiving T in the ToGA trial (median PFS = 6.7 months, median OS = 13.8 months).
Large-scale Real-time Reverse Transcription-PCR Approach of Angiogenic Pathways in Human Transitional Cell Carcinoma of the Bladder: Identification of VEGFA as a Major Independent Prognostic Marker
Authors: Géraldine Pignot, Ivan Bieche, Sophie Vacher, Catherine Güet, Annick Vieillefond, Bernard Debré, Rosette Lidereau, Delphine Amsellem-Ouazana
Journal: European Urology (2008)
Will livers be the third 'insurable' transplant?
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes in skin reactivity, specific IgE and IgG levels after one year of immunotherapy in olive pollinosis
Authors: L. Macchia, M. F. Caiaffa, G. Di Felice, C. Pini, G. Bariletto, S. Strada, A. Turn
Journal: Allergy (1991)

Changes in specific skin reactivity, specific IgE and specific IgG after immunotherapy (IT) were investigated in olive pollinosis. Thirty patients, receiving IT with commercial extracts, were studied in comparison with a control group of seven patients, receiving only drug therapy. Skin reactivity, IgE and IgG were assessed before starting IT and 1 year later. Definite changes in the three considered parameters occurred in patients given IT with Olea europaea extracts; no variation was observed in the control group. The specific skin reactivity, evaluated by means of quantitative skin prick tests, significantly decreased (Skin Index geometrical mean from 2.73 to 0.88, P &lt; 0.001); the specific IgE, measured by RAST, were surprisingly decreased (from 7.76 to 4.74 PRU/ml, P &lt; 0.001); the specific IgG, measured by ELISA, in basic conditions were detectable only in nine patients of 30, while, after IT, they were found in almost all patients with a remarkable increase (from 5.48 to 266.89 AU/ml, P &lt; 0.001). No correlation was found among the changes in the considered parameters, suggesting that, at least in olive pollinosis, specific skin reactivity, specific IgE and specific IgG are three variables depending on IT but reciprocally independent.
Giants and Dwarfs: A Study of the Anterior Lobe of the Hypophysis
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17440: Glycemic Variability Inflicts Injury on Non-infarct Area in Patients With Anterior ST-segment Elevation Myocardial Infarction
Authors: Yugo Minaimoto, Noriaki Iwahashi, Masaomi Gohbara, Shunsuke Kataoka, Ellchi Akiyama, Nobuhiko Maejima, Kengo Tsukahara, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura
Journal: Circulation (2015)

Background: Glycemic variability (GV) plays an important role in patients with ST-segment elevation myocardial infarction (STEMI), but the relationship between GV and the strain of left ventricle by cardiac magnetic resonance imaging (CMR) has not been examined. Methods: We investigated 55 patients with anterior STEMI who underwent reperfusion therapy within 12h onset. We analyzed GV, as determined by a continuous glucose monitoring system (CGMS; iPro2, Medtronic, Minneapolis, USA), and circumferential strain (CS) of the left ventricule by CMR. All patients were equipped with CGMS in a stable phase after admission. CMR were performed 7days and 7 months repeatedly. We checked CS at each segment as regional function and global CS as global function. Patients were classified into 2 groups according to the mean amplitude of glycemic excurtions (MAGE) that was calculated by measuring the arithmetic mean of the differences between consecutive peaks and nadirs if the differences were greater than 1 standard deviation; high-MAGE group and low-MAGE group. Results: There were no significant differences between high-MAGE and low-MAGE group regarding age (63.4±13.0 vs. 64.0±11.6 years) ,male gender (85% vs. 78%). High-MAGE group had more frequently with diabetes (44% vs. 3%, p&lt;0.001), greater peak creatine phosphokinase (CPK; 4619 vs. 2934U/L, p=0.02), lower global CS (-15.4±2.8% vs. -18.1±5.0%, p=0.01) and mid-inferior CS (-16.8±6.6% vs. -20.6±6.7%, p=0.04) at 7 months CMR. At late CMR, MAGE had significant correlation with global CS (R=0.3, p=0.024) and CS at mid-inferior (R=0.35, p=0.009). Multivariate analysis revealed that MAGE (β=0.35, p=0.009) were independently correlated with CS at mid-inferior, and peak CPK (β=0.398, p=0.003) were independently correlated with global CS. Conclusion: GV inflicted injury on non-infarct area after the onset of anterior STEMI. This may be related to left ventricular remodeling.
Surgery
Authors: Martin S. Litwin
Journal: JAMA (2007)

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Infection control in small hospitals. Prevalence surveys in 18 institutions
Authors: M. R. Britt
Journal: JAMA (1976)

In prevalence surveys of 18 small hospitals in the intermountain region, 20.4% of the patients had community-acquired infections and 7.2% had infections acquired in the hospital. The types of nosocomial infections and patterns of antibiotic usage were similar to those encountered in large hospitals. In the small hospitals, 49% of the suspected bacterial infections were cultured, whereas at a nearby large hospital 77% were cultured. Seventeen of these small hospitals had an infection-control committee but these committees were unable to assess adequately the extent of their nosocomial infection problems. Monitoring of the environment with bacterial cultures was a frequent practice; overall, a ratio of one environmental culture was performed to each three diagnostic cultures. These results indicate the need to develop and evaluate nosocomial infection control programs in small hospitals. (<i>JAMA</i>236:1700-1703, 1976)
Bioethics
Authors: Fredrick R. Abrams
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Houston
Authors: Samuel Wallace Bender
Journal: JAMA (2011)

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Left or Right?
Journal: JAMA (1963)

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A Practical Handbook of Diseases of the Ear.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BILATERAL EMPYEMA; STAPHYLOCOCCUS PYEMIA
Journal: JAMA (1920)

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Pediatricians participating in Medicaid
Authors: M. H. Fox
Journal: JAMA (1992)

<h3>To the Editor.</h3> —In their article on factors associated with pediatricians' participation in Medicaid in North Carolina, Margolis et al<sup>1</sup>concluded that higher reimbursement rates exert only modest effects on participation. They believe that a strategy aimed at improving pediatricians' knowledge of the program and at enlisting the support of community physicians would be more effective since participation appears to be strongly influenced by a pediatrician's familiarity with and attitude toward Medicaid. They also conclude that pediatricians who practice in smaller communities or areas with lower physician-to-patient ratios are more likely to accept Medicaid patients. In an effort to retain obstetricians' participation, the Maryland Medicaid program increased payments for deliveries from $265 to $550 in March and then to $795 in July 1986. The rationale was to eliminate the disparity in payment between Medicaid and private insurers and thereby to reduce financial disincentives toward participation. Recently, we evaluated the
Do alternate modes for transmission of human immunodeficiency virus exist? A review
Authors: A. R. Lifson
Journal: JAMA (1988)

Transmission of human immunodeficiency virus (HIV) is known to occur perinatally, through sexual contact, and after exposure to infected blood or blood products. The possibility that breast milk may transmit HIV continues to be evaluated. There is no epidemiologic evidence that contact with saliva, tears, or urine has resulted in HIV infection. However, because HIV has (in some cases rarely) been isolated from these body fluids, guidelines have been developed to reduce more extensive exposures to such secretions. Laboratory and epidemiologic data strongly indicate that HIV is not transmitted through immune globulin preparations, the hepatitis B vaccine, or contact with insects. Increasing evidence from many studies also indicates that HIV is not transmitted through casual contact. All individuals need to be aware of how HIV is and is not transmitted, to reduce high-risk behaviors and to avoid unnecessary fears and actions. (<i>JAMA</i>1988;259:1353-1356)
A quantitative, qualitative, and critical assessment of surgical waste. Surgeons venture through the trash can
Authors: M. E. Tieszen
Journal: JAMA (1992)

<h3>Objectives.</h3> —To quantitatively and qualitatively evaluate the surgical waste produced from several common surgical procedures, define categories of waste that might be readily separated for alternative disposal practices or substitution, and determine the change in surgical waste output that elimination or alternative handling methods may effect. <h3>Design.</h3> —A case series evaluating the surgical waste from five types of surgical procedures including operations of the back, heart, abdomen, hip and knee, and herniorrhaphies, prospectively identified and allocated at the availability of the investigator. <h3>Setting.</h3> —A single tertiary community teaching hospital. <h3>Outcome Measures.</h3> —Weight, volume, and percentage of disposable linen, paper, and plastic plus miscellaneous material from surgical waste with a later subset separating plastics from miscellaneous items to completely identify all categories. <h3>Results.</h3> —Surgical waste weighing 610.5 lb (274.7 kg) and occupying 171.6 cu ft (5.1 m<sup>3</sup>) from 27 cases was examined. Disposable linens accounted for 39% of the weight; paper, 7%; plastic, 26%; and miscellaneous waste, 27%. By volume, disposable linen and paper accounted for 69%; plastic, 23%; and miscellaneous waste, 7%. Disposable linen, paper, and recyclable plastic accounted for 73±7% (mean±SD) by weight and 93%±4% by volume of total surgical waste. <h3>Conclusion.</h3> —Nationally, annual surgical waste from these five procedures weighs 5.1×10<sup>7</sup>lb (2.3×10<sup>7</sup>kg) and occupies 1.4×10<sup>7</sup>cu ft (4.0×10<sup>5</sup>m<sup>3</sup>). By using reusable linen products and engaging in recycling methods currently available and feasible, we estimate that weight reductions of 73% and volume reductions of 93% in surgical waste are possible. (<i>JAMA</i>. 1992;267:2765-2768)