tbuckley/cabot-search huggingface dataset:
Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence
Authors: Christoph Wasem, Diana Arnold, Leslie Saurer, Nadia Corazza, Sabine Jakob, Simon Herren, Claudio Vallan, Christoph Mueller, Thomas Brunner
Journal: Journal of Clinical Investigation (2003)

Death receptor–mediated activation-induced apoptosis of antigen-specific T cells is a major mechanism of peripheral tolerance induction and immune homeostasis. Failure to undergo activation-induced cell death (AICD) is an important underlying cause of many autoimmune diseases. Thus, enhancing the T cell’s own suicide mechanism may provide an efficient therapy for the treatment of autoimmune diseases. Bisindolylmaleimide VIII (Bis VIII), a PKC inhibitor, can sensitize T cells for death receptor–induced apoptosis and thus can inhibit the development of T cell–mediated autoimmune disease in vivo. In this study, we have analyzed the functional consequences of accelerated suicide for a protective CD8+ T cell–mediated immune response. Our data indicate that CD8+ T cells are sensitized by Bis VIII to AICD, both in vitro and in vivo. The sensitizing effect of Bis VIII appears to be mediated by specific downmodulation of the antiapoptotic molecule cellular FLICE-like inhibitory protein (cFLIPL). Importantly, Bis VIII administration during an acute lymphocytic choriomeningitis virus (LCMV) infection causes the depletion of virus-specific CD8+ T cells and subsequently impaired cytotoxicity and virus clearance. We conclude that resistance to death receptor–induced apoptosis is crucial for the efficient induction of a protective immune response, and that Bis VIII–based immunotherapies have to be applied under well-controlled conditions to avoid the induction of immune incompetence and the inability to respond to pathogen infection.
Synthetic tumor-associated glycopeptide antigens.
Authors: H Kunz, P Wernig, M Schilling, J März, C Unverzagt, S Birnbach, U Lang, H Waldmann
Journal: Environmental Health Perspectives (1990)

Glycopeptides with TN antigen (GalNAc)Ser/Thr and T-antigen structures (beta Gall-3GalNAc)Ser/Thr, described as tumor-associated antigens, were synthesized and coupled to bovine serum albumin. Alternatively, synthetic methods for the construction of beta-anomeric analogues of the TN and T-antigen glycopeptides were developed, aiming at antigenic structures having a varied stereochemistry of the linkage between the carbohydrate and the peptide moiety. As a further type of potential tumor-associated antigen, fucosyl-chitobiose asparagine glycopeptides were synthesized, deprotected, and coupled to bovine serum albumin. The chemical methods developed now make the complex sensitive glycoprotein partial structures accessible in analytically pure form and in preparative amounts.
PELVIC DEFORMITY.
Authors: GEORGE M. BOYD
Journal: JAMA (1904)

Pregnancy or labor complicated by pelvic deformity will always be of great interest to the obstetrician. As the subject is one that has attracted attention from the earliest times, it would now seem that the ground had been pretty well covered, but there still exists some difference of opinion in regard to the treatment of these cases. My conclusions are the result of following the work of the Philadelphia Lying-in Charity Hospital for the past fifteen years, during which time over 10,000 cases have been cared for in its various departments. The hospital, owing to its central location, does a large amount of emergency work, many of the cases entering at the end of gestation, and some already in labor. When the American Medical Association last met at Atlantic City, in 1900, I presented to this Section a paper entitled "The Classical Cesarean versus the Porro Cesarean." In that paper<sup>1</sup>
2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Authors: John B. Buse, Deborah J. Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A. D’Alessio, Melanie J. Davies
Journal: Diabetes Care (2019)

The American Diabetes Association and the European Association for the Study of Diabetes have briefly updated their 2018 recommendations on management of hyperglycemia, based on important research findings from large cardiovascular outcomes trials published in 2019. Important changes include: 1) the decision to treat high-risk individuals with a glucagon-like peptide 1 (GLP-1) receptor agonist or sodium–glucose cotransporter 2 (SGLT2) inhibitor to reduce major adverse cardiovascular events (MACE), hospitalization for heart failure (hHF), cardiovascular death, or chronic kidney disease (CKD) progression should be considered independently of baseline HbA1c or individualized HbA1c target; 2) GLP-1 receptor agonists can also be considered in patients with type 2 diabetes without established cardiovascular disease (CVD) but with the presence of specific indicators of high risk; and 3) SGLT2 inhibitors are recommended in patients with type 2 diabetes and heart failure, particularly those with heart failure with reduced ejection fraction, to reduce hHF, MACE, and CVD death, as well as in patients with type 2 diabetes with CKD (estimated glomerular filtration rate 30 to ≤60 mL min–1 [1.73 m]–2 or urinary albumin-to-creatinine ratio &amp;gt;30 mg/g, particularly &amp;gt;300 mg/g) to prevent the progression of CKD, hHF, MACE, and cardiovascular death.
Hand, Foot, and Mouth Disease
Authors: R. P. Warin
Journal: BMJ (1964)

<h3>Objectives</h3> To determine the frequency and nature of erroneous transfer of medication information (medication errors) upon admission to hospital and to study the effect of medication reconciliation. <h3>Methods</h3> Included patients were 65 years of age or older, were living in nursing homes or in their own home with care provided by the community nursing system and had been admitted to hospital. The patients’ medication lists from the community were compared with the hospital medication lists upon admission in order to study the discrepancies between the lists. The proportion of errors that were corrected by day 4 of hospitalisation was also studied as a measure of the effect of medication reconciliation conducted by clinical pharmacists who aimed to identify the patients’ accurate and complete medication history. <h3>Results</h3> A total of 149 patients were included over a 10-month period. In 68 (46%) patients, there occurred at least one medication error, with an average of 0.95 errors per patient. Overall, 8.0% of all drug transfers were found to be incorrect. The clinical pharmacists detected all medication errors upon admission and 43% of them were corrected before day 4 of hospitalisation. <h3>Conclusions</h3> Medication errors upon admission to hospital are common; use of clinical pharmacists in the admission medication reconciliation process appears to be a useful method to reduce medication errors, but since our study lacked a control group further studies are needed to show the actual impact of pharmacist-led medication reconciliation upon admission to hospital. Furthermore, more actions are needed to enhance the safety and quality of medication information transfers.
Increasing The Accuracy Of Peanut Allergy Diagnosis Using Ara H2
Authors: T.D. Dang, S. Choo, P.V. Licciardi, J.J. Koplin, P.E. Martin, T. Tan, L.C. Gurrin, D. Tey, M. Robinson, S. Dharmage, M. Tang, K.J. Allen
Journal: Journal of Allergy and Clinical Immunology (2012)
Invertebrates in Testing of Environmental Chemicals: Are They Alternatives?
Authors: Laurent Lagadic, Thierry Caquet
Journal: Environmental Health Perspectives (1998)

An enlarged interpretation of alternatives in toxicology testing includes the replacement of one animal species with another, preferably a nonmammalian species.This paper reviews the potential of invertebrates in testing environmental chemicals and provides evidence of their usefulness in alternative testing methodologies.The first part of this review addresses the use of invertebrates in laboratory toxicology testing.Problems in extrapolating results obtained in invertebrates to those obtained from vertebrates are noted, suggesting that invertebrates can essentially be used in addition to rather than as replacements for vertebrates in laboratory toxicity tests.However, evaluation of the ecologic impact of environmental chemicals must include defining end points that may frequently differ from those classically used in biomedical research.In this context, alternative approaches using invertebrates may be more pertinent.The second part of the review therefore focuses on the use of invertebrates in situ to assess the environmental impact of pollutants.Advantages of invertebrates in ecotoxicologic investigation are presented for their usefulness for seeking mechanistic links between effects occurring at the individual level and consequences for higher levels of biologic organization (e.g., population and community).In the end, it is considered that replacement of vertebrates by invertebrates in ecotoxicity testing is likely to become a reality when basic knowledge of metabolic, physiologic, and developmental patterns in the latter will be sufficient to assess the effect of a given chemical through end points that could be different between invertebrates and vertebrates.
Plasma demeclocycline levels and nephrotoxicity. Correlation in hyponatremic cirrhotic patients
Authors: P. D. Miller
Journal: JAMA (1980)

In five hyponatremic, cirrhotic patients, demeclocycline hydrochloride was used to inhibit the hydroosmotic effect of vasopressin. In four, renal impairment developed during the 7 to 20 days of demeclocycline hydrochloride (900 to 1,200 mg/day) administration. In these four patients, creatinine clearance fell (72 to 20 mL/min,<i>P</i>&lt;.01) as BUN (12 to 47 mg/dL,<i>P</i>&lt;.02) and serum creatinine (0.9 to 4.2 mg/dL,<i>P</i>&lt;.01) levels rose. The azotemic effect of the drug could not be accounted for consistently by volume depletion secondary to its natriuretic effect. However, a close correlation between plasma demeclocycline levels and its azotemic effect was observed. We conclude that a nephrotoxic effect of demeclocycline severely limits its usefulness in treating hyponatremia in the cirrhotic patient. (<i>JAMA</i>243:2513-2515, 1980)
Efficacy of ganciclovir in the treatment of hepatitis B virus infection of the liver graft. Long-term results M de la Mata, JL Montero, E Fraga, G Cost�n, M Delgado, P L�pez, R Gonz�lez, C Pera, G Mino. H. Reins Sofia.Cdrdoba, Spain
Journal: Hepatology (1995)
Amer J of Roentgenology, Springfield, Ill
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lovett's Lateral Curvature of the Spine and Round Shoulders.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SECTION OF DERMATOLOGY.
Journal: British Journal of Dermatology (1964)

British Journal of DermatologyVolume 76, Issue 11 p. 480-491 SECTION OF DERMATOLOGY. First published: November 1964 https://doi.org/10.1111/j.1365-2133.1964.tb15490.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume76, Issue11November 1964Pages 480-491 RelatedInformation
INDUSTRIAL BLOOD POISONS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From India to the Planet Mars: a Study of a Case of Sonambulism with Glossolalia.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospitals, Chicago
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ELECTRIC POSSIBILITIES.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dynamin is involved in human epithelial cell vacuolation caused by the Helicobacter pylori-produced cytotoxin VacA
Authors: Junko Suzuki, Hirohide Ohnishi, Hiroshi Shibata, Akihiro Wada, Toshiya Hirayama, Taroh Iiri, Namiki Ueda, Chiho Kanamaru, Tomohiro Tsuchida, Hirosato Mashima, Hiroshi Yasuda, Toshiro Fujita
Journal: Journal of Clinical Investigation (2001)

The peptide concentration on the x-axis of figure 2 should read pmol/cm 2 .The concentrations mentioned in the text and legends, which were based on this figure, should also read pmol/cm 2 .The corrected figure and legend appear below.
Hypertensive Emergencies
Authors: Jan Koch-Weser
Journal: New England Journal of Medicine (1974)

HYPERTENSION rarely constitutes a medical emergency. Ideally, the hypertensive patient is detected early, and his hypertensive mechanisms are characterized and corrected by appropriate, orally active drugs. Titration of dosage against blood-pressure response and adverse drug effects should usually take several weeks of ambulatory observation. Rapid normalization of blood pressure is unnecessary, often uncomfortable and sometimes hazardous.Systematic, gradual institution of antihypertensive therapy is impossible in untreated or poorly treated hypertensive patients who present as hypertensive emergencies. These crisis situations constitute failures of medical care and have become gratifyingly less common during recent years. They are life-threatening disorders usually characterized by . . .
Alterations in the K-ras and p53 Genes in Rat Lung Tumors
Authors: Steven A. Belinsky, Deborah S. Swafford, Gregory L. Finch, Charles E. Mitchell, Gregory Kelly, Fletcher F. Hahn, Marshall W. Anderson, Kristen J. Nikula
Journal: Environmental Health Perspectives (1997)

Activation of the K-ras protooncogene and inactivation of the p53 tumor suppressor gene are events common to many types of human cancers.Molecular epidemiology studies have associated mutational profiles in these genes with specific exposures.The purpose of this paper is to review investigations that have examined the role of the K-ras and p53 genes in lung tumors induced in the F344 rat by mutagenic and nonmutagenic exposures.Mutation profiles within the K-ras and p53 genes, if present in rat lung tumors, would help to define some of the molecular mechanisms underlying cancer induction by various environmental agents.Pulmonary adenocarcinomas or squamous cell carcinomas were induced by tetranitromethane (TNM), 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK), beryllium metal, plutonium-239, X-ray, diesel exhaust, or carbon black.These agents were chosen because the tumors they produced could arise via different types of DNA damage.Mutation of the K-ras gene was determined by approaches that included DNA transfection, direct sequencing, mismatch hybridization, and restriction fragment length polymorphism analysis.The frequency for mutation of the K-ras gene was exposure dependent.Only two agents, TNM and plutonium, led to mutation frequencies of > 10%.In both cases, the transition mutations formed could have been derived from deamination of cytosine.The identification of non-ras transforming genes in rat lung tumors induced by mutagenic and nonmutagenic exposures such as NNK and beryllium would help define some of the mechanisms underlying cancer induction by different types of DNA damage.Alteration in the p53 gene was assessed by immunohistochemical analysis for p53 protein and single-strand conformation polymorphism (SSCP) analysis of exons 4 to 9. None of the 93 adenocarinomas examined was immunoreactive toward the anti-p53 antibody CM1.In contrast, 14 of 71 squamous cell carcinomas exhibited nuclear p53 immunoreactivity with no correlation to type of exposure.However, SSCP analysis only detected mutations in 2 of 14 squamous cell tumors that were immunoreactive, suggesting that protein stabilization did not stem from mutations within the p53 gene.Thus, the p53 gene does not appear to be involved in the genesis of most rat lung