tbuckley/cabot-search huggingface dataset:
Histological characterization of muscle and adipose tissue in patients with cirrhosis receiving liver transplant
Authors: Maryam Ebadi, Vera C. Mazurak, Vickie Baracos, Abha Dunichandhoedl, Elora Rider, Khaled Dajani, David Bigam, Norman Kneteman, James Shapiro, Aldo J Montano-Loza
Journal: Journal of Hepatology (2020)
Shingles. Sorrows, salves, and solutions
Authors: S. E. Straus
Journal: JAMA (1993)

<h3>SELECTED CASES</h3><h3>Case 1</h3> A 56-year-old woman with advanced lymphoma presented with numerous coalescing lesions confined to the distributions of the left maxillary and ophthalmic divisions of the fifth cranial nerve. Ulcerations were also apparent on the left hemipalate. She had completed radiotherapy months before, but she continued to receive aggressive, multidrug chemotherapy, with the last course within days of the onset of the rash. Lesions were culture positive for varicella-zoster virus (VZV). Treatment was begun with high-dose intravenous acyclovir and continued for 7 days until new vesicles stopped forming. Nonetheless, existing lesions evolved into a confluent eschar (Fig 1, left). She then experienced an episode of mental confusion and right-sided paresis presumed to be secondary to virus-associated granulomatous angiitis of the left middle cerebral artery. Then all the teeth in her left maxillary arch loosened and were lost. Left maxillary sinusitis developed, necessitating antibiotics and surgical creation of a
THE PRURITUS OF JAUNDICE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Squirrel bites
Authors: J P Wyatt
Journal: BMJ (1994)

Asthma prevalence has increased worldwide; although less so in developed countries recently. This study assessed changes in the prevalence of asthma and related symptoms in the Busselton community since 1966. Cross-sectional respiratory health surveys of Busselton adults were conducted in 1966, 1969, 1972, 1975, 1981, 1990 and 2005–2007. Logistic regression models were used to estimate prevalence rates of asthma, respiratory symptoms, smoking, airway hyperresponsiveness (AHR) and atopy and to make comparisons in 2005–2007 and previous survey years. Asthma was defined as ever having doctor-diagnosed asthma (DDA). The prevalence of DDA was around 6% from 1966 to 1975, 8% in 1981 and rose to 19% in 2005–2007. From 1981 to 2005–2007, smoking prevalence declined and obesity and atopy increased but changes in these variables explained only a small part of the increase in DDA. Wheeze and cough/phlegm increased but AHR, breathlessness and doctor-diagnosed bronchitis remained relatively stable over the same period. These observations indicate that the increase in DDA is partly explained by increased symptoms and atopy. The lack of changes in AHR and doctor-diagnosed bronchitis suggests that factors such as diagnostic transfer and increased awareness of asthma have also contributed to the rise in prevalence of DDA.
Erratum
Authors: Luigi Lombardo, Emanuela Morelli, Massimiliano Luciani, Fernando Bellizzi, Paola Aceto, Italo Penco, Ian M. Kronish, William F. Chaplin, Nina Rieckmann, Matthew M. Burg, Karina W. Davidson, Carlo Lai, H.J. Rogier Hoenders, Elisabeth H. Bos, Joop T.V.M. de Jong, Peter de Jonge, Martin Grosse Holtforth, Adele M. Hayes, Marielle Sutter, Katharina Wilm, Emma Schmied, Jean-Philippe Laurenceau, Franz Caspar, Richard Balon, L. Minervini, F. Antonielli Romanini, M. Solmi, A. Passamani, E. Sferrazza, F. Schifano, Ethy Dorrepaal, Kathleen Thomaes, Johannes H. Smit, Anton J.L.M. van Balkom, Dick J. Veltman, Adriaan W. Hoogendoorn, Nel Draijer, Vicent Balanzá-Martínez, Juan Carlos Ruiz-Ruiz, Anabel Martínez-Arán, Manuel Girón, Brisa Solé, José Sánchez-Moreno, Manuel Gómez-Beneyto, Eduard Vieta, Rafael Tabarés-Seisdedos, Inmaculada Fuentes-Durá, Sammy K. Cheng, Janine Dizon, Rosalind van der Lem, Nic J.A. van der Wee, Tineke van Veen, Frans G. Zitman, Jess G. Fiedorowicz, William H. Coryell, John P. Rice, Lois L. Warren, William G. Haynes, George Anderson, Satz Mengensatzproduktion, Druck Reinhardt Druck Basel, Druck Reinhardt Druck Basel
Journal: Psychotherapy and Psychosomatics (2012)
BERLIN
Journal: JAMA (1927)

<h3>The Need of Pure Milk for Infants</h3> At a recent meeting of the Verein für innere Medizin und Kinderheilkunde, Professor Reyher demanded that cow's milk destined for infants' use shall be pure and rich in vitamins when produced and that it shall also be kept in that condition until it is used. Not only the summer peak of the infant mortality curve but also the winter peak, which is caused by respiratory infections, are closely related to the pure milk question. Although the children die from the bacterial insult, their illness may develop as the result of damaged nutrition, which weakened their resistance and exposed them to infection. The pediatrician demands for infant feeding the presence of vitamin B (the antiberiberi vitamin) and vitamin C (which prevents scurvy). The fat content is much less important. The results obtained with the various kinds of milk used in this region did not
Abstract P063: Defects in Well-Being Psychological Factors Rather Than Ill-Being Factors Are Predictors of Acute Coronary Syndrome: A Comprehensive Lifestyle Analysis
Authors: Ick-Mo Chung, Jisun So, Jihyeon Seo, Hyejin Chun, Byungmi Kim, Kyong-Mee Chung, Sung Nim Han
Journal: Circulation (2015)

Introduction: An increasing body of evidence suggests that development of coronary artery disease (CAD) is probably affected by a variety of lifestyle factors. However, most studies have not assessed comprehensive lifestyle factors including well-being psychological factors simultaneously, therefore relative contribution of each factors is obscure. Hypothesis: A variety of lifestyle factors including defect in well-being psychological factors may contribute to development of CAD through interacting muturally. Methods and Results: A case-control, cross-sectional study analyzing comprehensive lifestyle factors of patients with acute coronary syndrome (ACS) and healthy control was conducted. 92 patients with ACS (73 male; 53.2 yr; 30 acute MI, 62 unstable angina) and 69 healthy control (43 male; 48.7yr) were recruited. For dietary analysis, food frequency questionnaire (FFQ) and 2 days of 24 hour dietary recall were used. Anxiety, depression, stress, job stress, and hostility were analyzed to assess psychological ill-being factors. Primary and secondary control strategies, health-related quality of life (HRQoL), and satisfaction degree in 7 life domains such as marriage, leisure, standard of living, job, family, sex life, and self were analyzed to assess well-being factors. Univariate analysis showed that ACS group vs. control group had more current/ex-smoker and exercised less (all, p&lt;0.05). FFQ analysis showed that ACS group vs. control consumed more energy intake, fats, proteins, seafoods, and sweets (all, p&lt;0.05). Psychological analysis showed that the ACS group had more depressive score, less mean satisfaction score in all 7 life domains, and less physical domain of HRQoL especially in the fields of 1) general health perceptrion and 2) bodily pain (all p&lt;0.05). The ACS group vs. control tended to use more primary control strategy, although not reaching statistical signifcance. Logistic regression analysis, after adjustment of age and gender, identified that mean satisfaction score in 7 life domains (OR: 9.66), primary control strategy (OR: 1.92), greater intake of sea foods (OR 6.53) and sweets (OR: 7.40), exercise (OR: 0.26), and smoking (OR:7.53) were determined as significant independent predictors of ACS (all, p&lt;0.05). Conclusions: Defects in well-being psychological factors rather than ill-being factors are closely associated with ACS. A variety of lifestyle factors, especially, poor satisfaction in 7 life domains, use of primary control strategy, greater intake of sea foods and sweets, smoking, and poor exercise are independent predictors of ACS. Therefore preventive intervention trial of ACS should include modification of comprehensive lifestyle factors including defects in well-being factors.
Hepatic adenomata with type 1 glycogen storage disease
Authors: R. R. Howell
Journal: JAMA (1976)

In older patients with glucose-6-phosphatase deficiency, adenomatous nodules develop within the liver parenchyma. Investigation of eight such patients, age 3 to 28 years, using radioisotopic scans, has demonstrated areas of depressed isotope uptake in the liver in all except the one preteenaged child. Three patients were further studied with hepatic angiograms and liver biopsy specimens. A diffuse nodularity, more widespread than apparent on isotopic scans, was demonstrated on angiograms. Although initial histologic study in each case showed adenomatous tissue without evidence of neoplasm, the development of hepatocellular carcinoma in one of our patients and in others from the literature suggests that the nodules may be premalignant. (<i>JAMA</i>236:1481-1484, 1976)
Thromboplastin generation test
Authors: A. J. Quick
Journal: JAMA (1967)

In the classical theory of blood coagulation, it was postulated that prothrombin was converted to thrombin through the action of calcium and thromboplastin. It is now established that circulating blood contains no active thromboplastin but that thromboplastin is generated during coagulation. The three major factors required for its production are platelets, factor VIII, and factor IX, the agents lacking in thrombocytopenic purpura, hemophilia, and Christmas disease (hemophilia B), respectively. Biggs and Douglas<sup>1</sup>devised a direct method for measuring the generation of thromboplastin by mixing (1) platelets; (2) diluted plasma adsorbed with aluminum hydroxide which retains its concentration of factor VIII but is devoid of prothrombin and factors VII, IX, and X; and (3) serum which is low in prothrombin, devoid of factor VIII, but rich in factor IX. On recalcification and incubation a thromboplastin activity develops which is measured on normal plasma by a one-stage prothrombin technique. When the
Erythromycin ointment for ocular prophylaxis of neonatal chlamydial infection
Authors: M. R. Hammerschlag
Journal: JAMA (1980)

We compared the efficacy of erythromycin ophthalmic ointment vs 1% silver nitrate drops for the prevention of neonatal conjunctivitis or respiratory tract infection from<i>Chlamydia trachomatis</i>. The organism was isolated from the cervix of 67 (12%) of 572 pregnant women. They gave birth to 559 infants who were randomly assigned to either prophylaxis immediately after birth. Thirty-six of 60 infants born to<i>Chlamydia</i>-positive women received silver nitrate; 24 received erythromycin. Twelve (33%) of the 36 infants who received silver nitrate had chlamydial conjunctivitis, but none of the 24 infants who received erythromycin did. Ten (29%) of 36 infants receiving silver nitrate had chlamydial nasopharyngeal infection (three later had pneumonia), as opposed to five (21%) of 24 who received erythromycin (one had pneumonia). Thus, erythromycin ointment is effective in prevention of chlamydial conjunctivitis, but it may not reduce nasopharyngeal infection or subsequent pneumonia. (<i>JAMA</i>244:2291-2293, 1980)
The relationship between left ventricular hypertrophy and flow-mediated dilation of the brachial artery in normal coronary angiographic hypertensive patients Ertugrul Ercan, Ceyhun Ceyhan, Cemil Gurgun, Mehdi Zoghi, Oguz Yavuzgil, Azem Ak�ll�, Cunety Turkoglu, Mustafa Ak�n. Ege University Medical School Cardiology Department, Izmir, Turkey
Journal: Journal of the American College of Cardiology (2001)
B.C.G
Authors: W. E. Snell
Journal: BMJ (1956)

JOURNAL923deal with the pre-employment and annual x-rays of employees from the industries in the neighbourhood.It could also deal with employees of local authorities, school teachers, usually employed by local authorities, pregnant women from local authority antenatal clinics, and children found to be Mantoux-positive as the result of routine annual tuberculin testing.It is a waste of everyone's time to carry out M.M.R. x-ray examination on children under 15 without the preliminary tuberculin test, and, as Drs.Lissant Cox and A. L. Cochrane and Professor J. Crofton say (Journal, March 24, p. 684), merely swells the numbers.Two important groups that should certainly be covered by the M.M.R. surveys are immigrants and vagrants.Although there is some division of opinion upon the political implications of surveying immigrants, the methods
14P Adipose tissue-derived stem cells provide an advantageous tumor microenvironment in gastric cancer
Authors: J. Kinoshita, S. Fushida, S. Harada, K. Oyama, T. Yamaguchi, A. Hirose, K. Okamoto, K. Nakamura, T. Miyashita, H. Tajima, H. Takamura, I. Ninomiya, T. Ohta
Journal: Annals of Oncology (2016)
Cigarette smoking history predicts sensitivity to erlotinib: Results of a phase II trial in patients with bronchioloalveolar carcinoma (BAC)
Authors: M. G. Kris, A. Sandler, V. Miller, M. Cespon, M. Zakowski, B. Pizzo, E. Venkatraman, J. Gomez, D. Johnson, D. Carbone
Journal: Journal of Clinical Oncology (2004)

7062 Background: The most dramatic benefits seen with epidermal growth factor receptor tyrosine kinase inhibitors in patients with NSCLC occur with BAC. For gefitinib, BAC histology and cigarette smoking history predict sensitivity. We now report pretreatment factors associated with radiographic response after erlotinib (Tarceva) in patients with any BAC features (Ebright MI. Ann Thorac Surg 2002) in tumor specimens. Methods: 127 patients with stage IIIB/IV, inoperable NSCLC underwent central review of biopsies. BAC was found in 65%. To date, 69 have received erlotinib 150mg PO daily. Results: Patients: median age 65 (range 33–85 yrs), 64% women, 26% prior chemotherapy, 91% KPS ≥ 80%, Path: 25%
Regression of Left Ventricular Hypertrophy After Surgical Therapy for Aortic Stenosis Is Associated With Changes in Extracellular Matrix Gene Expression
Authors: Thomas Walther, Andreas Schubert, Volkmar Falk, Christian Binner, Andreas Kanev, Sabine Bleiziffer, Claudia Walther, Nico Doll, Rüdiger Autschbach, Friedrich W. Mohr
Journal: Circulation (2001)

Background Regression of left ventricular hypertrophy (LVH) after surgical correction for aortic stenosis is not fully understood on the molecular level. The aim of this study was to examine whether there is an association between LVH regression and extracellular matrix (ECM) gene expression. Methods and Results A standard model of controlled LVH induction by supracoronary banding (A=baseline) was applied in 44 growing sheep (age, 6 to 8 months). Surgical correction to release the pressure gradient was performed 8.3±1 months later (B). The animals were killed after another 10.1±2 months (C). At all time points, hemodynamic evaluations and quantitative analysis of mRNA and protein expression for matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) was performed. Left ventricular mass index was 82±21 (A) versus 150±33 (B), P &lt;0.01, and 78±18 g/m 2 (C), P &lt;0.01. Left ventricular function and cardiac index remained stable. Myocardial fiber diameter index was 9.1±1.2 (A) versus 12.3±1.4 (B), P &lt;0.01, and 8.4±1.3 μm/m 2 (C), P &lt;0.01. In parallel to the development of LVH at B, gene expression was increased significantly for MMP-1, MMP-2, MMP-3, and MMP-9 and for TIMP-1 and TIMP-2 and decreased significantly for TIMP-3. After surgical correction (C), there was a complete regression of gene expression to baseline measures. Conclusions Controlled induction of compensated LVH leads to significant increase in ECM gene expression. The regression of LVH after surgical therapy is associated with complete regression of ECM gene expression. However, no cause-and-effect relation could be demonstrated.
Routine preoperative screening for HIV. Does the risk to the surgeon outweigh the risk to the patient?
Authors: M. D. Hagen
Journal: JAMA (1988)

EVEN among our society's leaders, the growing epidemic of human immunodeficiency virus (HIV) infection has produced panic. A presidential candidate (<i>New York Times</i>, June 7, 1987, section 4, p 1) and a US senator (<i>Wall Street J</i>, June 18,1987, p 33) have suggested that we quarantine people who are infected. School boards have barred seropositive children from the classroom; ministers have excluded them from church.<sup>1</sup>A clergyman has proposed that police officers should be authorized to shoot anyone suspected of being infected if that person threatens to bite them (<i>USA Today</i>, Aug 14,1987, p 3A). Some of our colleagues would refuse to provide care to infected patients.<sup>2</sup>None of these responses are either reasonable or humane. To criticize them, however, is not enough. We also must examine critically our profession's reactions to the crisis. As physicians, we must be logical in our responses and responsible in our leadership.
Diseases of Infancy and Childhood, Their Dietetic, Hygienic and Medical Treatment. A Text-Book Designed for Practitioners and Students in Medicine. In two volumes.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Pediatrics (2014)

Probiotics in Colic, Regurgitation, and Constipation 228Infantile colic, gastroesophageal reflux, and constipation are the most common functional gastrointestinal disorders that lead to referral to a pediatrician during the first 6 months of life.Indrio and colleagues randomized 589 newborns to receive Lactobacillus reuteri or placebo during the first 3 months of life.Five drops of the probiotic daily resulted in a reduction of crying time from 71 to 38 minutes per day and reduction in the mean number of regurgitations per day.In their editorial, Chumpitazi and Shulman discuss the implications of the study and the need for long-term examination of the effects on the microbiome.
Meta-analysis
Authors: Stephen B. Thacker
Journal: JAMA (1988)

Meta-analysis is being used with increasing frequency in clinical medicine as an attempt to improve on traditional methods of narrative review by systematically aggregating information and quantifying its impact. Combining data from several studies using meta-analysis can increase statistical power, provide insight into the nature of relationships among variables, and increase generalizability of results more rigorously than less quantitative review methods. Like all review methods, meta-analysis can be limited by sampling bias, inadequate data, and biased outcome interpretation. Still, the advantages noted above make meta-analysis a methodology that warrants testing and empirical evaluation. (<i>JAMA</i>1988;259:1685-1689)
Relevance of osteoporosis in women with fracture of the femoral neck
Authors: J. C Stevenson, M. I Whitehead
Journal: BMJ (1984)

sion ?If treated with an up to date drug regimen what success is achieved in blood pressure reduction ?We hope to publish results within the next year, and should the MRC trial show benefits from the treatment of mild to moderate hypertension, we will be able to comment on case finding and general practitioner follow up as a practical alternative to an expensive screening technique.This will have important consequences for general practice, for the National Health Service, and, most im- portantly, for the patient.
Outbreak of Chronic Arsenic Poisoning among Retired Workers from an Arsenic Mine in Japan
Authors: Noburu Ishinishi, Yasushi Kodama, Koichi Nobutomo, Takeo Inamasu, Eizaburo Kunitake, Yoshinori Suenaga
Journal: Environmental Health Perspectives (1977)

Retired former workers of Matsuo Arsenic Mine of Miyazaki prefecture in Japan were subjected to extensive medical examination. The number of retired workers subjected to examination were 61 of 208 workers who were engaged in the works of the mine and were tracked down by the work rolls. These workers left the mine more than 15 years prior to the time of the examination. The main works in the mine were classified as mining, dressing of ores, refining, and clerical work. Several findings such as arsenodermatitis, depigmentation, performation of nasal septum, hyposmia, anosmia, and peripheral nervous disturbance attributed to exposure to arsenic were observed in 9 of 21 roasters who often worked in the arsenic kitchen. No characteristic findings of arsenic poisoning, that is, gastrointestinal disturbance, disorder of the cardiovascular system, hematopoietic disorders, or liver disturbance were observed in the retired workers. Another notable finding was that 8 cases diagnosed as pneumoconiosis were found in 18 miners.
TRANYLCYPROMINE SULFATE
Authors: O H BEAHRS, V T CALDAROLA, E G HARRISON
Journal: JAMA (1964)

It has been six months since tranylcypromine sulfate (Parnate) was taken off the market by its manufacturer. This action occurred after strong pressure from the FDA, but under firm protest by the company. Widespread publicity associated with the event, much of it ill-advised and unnecessarily hysterical, embarrassed some physicians and caused their patients undue anxiety. Subsequent to the withdrawal of the drug, conflicting statements emanated from both the company and the FDA, whereupon the manufacturer requested a public hearing. From statements voiced by eminent physicians, it was evident that medical opinion was divided regarding the potential benefit of the drug as related to its potential hazards. Shortly before the hearing was to be held, the FDA announced that, after further review and study, it was permitting tranylcypromine to return to the market. The condition attached was that the manufacturer give emphatic attention to all potential hazards associated with the drug,