tbuckley/cabot-search huggingface dataset:
THE ELECTROENCEPHALOGRAM
Authors: P. W. C.
Journal: Annals of Internal Medicine (1949)

Editorial1 October 1949THE ELECTROENCEPHALOGRAMP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-4-698 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe recent appearance of Electroencephalography and Clinical Neurophysiology ("The EEG Journal") under the auspices of the International Federation of EEG Societies serves to emphasize the growth and the increasing importance of this highly specialized field of medicine. Almost everyone has heard of the "brain waves" and is aware that they are used in diagnosis. Many, however, even among physicians, do not know precisely in what disorders the EEG is really useful in diagnosis and particularly are not aware of its present limitations. Some knowledge of the nature of the observations on which conclusions are based, as well as of sources... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1949Volume 31, Issue 4Page: 698-702KeywordsBrainElectroencephalographyNeurophysiology ePublished: 1 December 2008 Issue Published: 1 October 1949 PDF downloadLoading ...
THE NATURE OF NERVE IMPULSES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiologie obstétricale, normal et pathologique.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Percentage Error in: Effect of Dietary Protein Content on Weight Gain, Energy Expenditure, and Body Composition During Overeating: A Randomized Controlled Trial
Authors: Hooman Kamel, Babak Navi, Jahan Fahimi, Fahimi Kamel
Journal: JAMA (2012)

Several factors may explain static ambulance use since the approval of time-sensitive therapy for ischemic stroke.Educational efforts may not be adequately addressing poor public knowledge about stroke, additional behavioral barriers may remain among those with adequate knowledge, or the response of health care providers to patients with stroke symptoms may be imperfect. 3Our findings suggest that national efforts to address barriers to ambulance use among patients with stroke need to be intensified or adjusted.
Hepatic recognition and catabolism of serum glycoproteins
Authors: G. Ashwell
Journal: JAMA (1981)

WITH THE exception of albumin, essentially all serum proteins are glycoproteins, that is, proteins to which one or more carbohydrate chains are bound in covalent linkage. The sugars most commonly found in association with proteins are galactose, mannose,<i>N</i>-acetylhexosamine, sialic acid, and fucose. Glucose occurs rarely, if at all, as a normal constituent of circulating proteins. In general, the carbohydrate moiety may be envisaged as consisting of two domains. The outer, nonreducing terminus is composed of the trisaccharide, sialic acid-galactose-<i>N</i>-acetylglucosamine. Usually, between two and four such terminal triads may be linked glycosidically to the second domain, which is composed of three mannose and two<i>N</i>-acetylglucosamine residues. The structure of a typical, complex carbohydrate chain is illustrated in the Figure. On treatment with neuraminidase, the sialic acid moiety is cleaved to reveal the penultimate galactose moiety as the new, nonreducing termini of the resulting asialoglycoprotein. Fucose, which
Contribution of Serum and Cellular Factors in Host Defense Reactions
Authors: K. Frank Austen, Zanvil A. Cohn
Journal: New England Journal of Medicine (1963)

Natural Antibody and ProperdinProperdin was originally defined by Pillemer and his associates68 as a serum protein that reacted with zymosan, an insoluble carbohydrate from yeast-cell walls, only at temperatures above 15°C. and in the presence of magnesium ion and certain nondialyzable serum factors resembling complement; subsequent elevation of the reaction temperature to 37°C. was stated to inactivate C′3 without appreciably fixing other components. Quantitation of C′3 inactivation served as the basis for the properdin assay. The uniqueness of this protein resided in the interpretation of the in vitro studies as indicating that it was not antibody69 whereas its significance . . .
Abstract 324: Identification of Regulators of Cardiac DNA Methylation Using a Systems Genetics Approach in Mice
Authors: Christoph D Rau, Milagros Romay, Eleanor Wong, Wilson Tan, Aldons J Lusis, Roger Foo, Yibin Wang
Journal: Circulation Research (2017)

Systems biology approaches to studying heart failure in humans are hampered by numerous environmental factors and inciting incidents which combine to complicate the application of standard population-based tools and algorithms to the syndrome. We recently reported a study of heart failure in a large cohort of inbred mouse strains (the Hybrid Mouse Diversity Panel; HMDP) treated with the beta-adrenergic agonist isoproterenol. We demonstrated that it was possible to combine systems-level tools with the benefits of an animal model to capture and identify numerous genetic variations which drive heart failure. Recent research on the epigenome has identified changes to DNA methylation which affect the progression of cardiovascular diseases and suggests that DNA methylation may serve as an important additional marker or even driver of genes involved in heart failure-associated phenotypes. We have supplemented our prior study by completing reduced representational bisulfite sequencing on 88 strains from our panel both with and without catecholamine challenge. We have identified 75,000 CpGs which vary among the strains of the HMDP across the genome. Each CpG was mapped to the genome using GWAS to identify methylation quantitative trait loci (mQTLs). These mQTLs were then grouped together to identify mQTL hotspots, regions on the genome which regulate a sizable fractions of all observed CpGs. We then overlapped these hotspots with hotspots which regulate the expression of gene transcripts. Three genomic regions were identified as multi-omic master regulators which affect both DNA methylation and gene expression for over 5% of the expressed transcripts and varying CpGs. Closer examination of these loci identified the serine peptidase inhibitor Serpina3n as a likely candidate gene for the regulation of DNA methylation, gene expression and cardiac phenotypes. Subsequent in vitro and in vivo work demonstrate that Serpina3n knockdown results in reduced cellular hypertrophy and changes to hypertrophy-related gene expression. Further analysis of the other master regulatory regions will likely reveal additional genes which will improve our understanding of how DNA methylation acts to regulate pathways underlying heart failure.
Dyspepsia, H pylori and bleeding
Authors: K Bodger, M Daly, R Heatley, ; St, Ma Patel, M Thomas, L Ballam, M Mendall, T Northfield, C Hawkev', A Swannell, G Yeomans', E Lofberg'
Journal: Gut (1996)

Background Dyspepsia (symptoms referable to the proximal alimentary tract) accounts for 5% of workload in primary care, yet relatively little is known about the characteristics of patients who consult with such symptoms.Data relating to case mix is a vital pre-requisite for the development of clinical guidelines which are responsive to the needs of GPs, and will allow targeting of specialist advice and resources to relevant patient sub-groups.Methods Data was collected on consecutive patients consulting GPs at 3 multi-partner practices, with a total target population (list size) of 22,549.Demographic data, and details of symptoms, recent drug therapy, and past investigations were recorded prospectively.We report data from the first 400 consultations, relating to 220 individual patients.Results Demographics: Mean age (Sd): 54 (17), 32% under 45 years; M F: 114/106; Symptoms: see table; 20 (9%) had 'sinister' symptoms.Investigations: see table; previously investigated=131(60%); >1 test=25(11%); timing (mean) = 6 years ago (range: 0 -40 yrs).Recent therapy: see table; 30(14%) taking antacids already, 103(38%) taking acid-suppressing drugs [ASDJ, 28(13%) taking NSAIDs.N EP HR W-Recet Recent Group % % % NSAID % ASD % Totab paients 220 41.8 35 23.2 12.7 37.7 Uninvesigaed patents 89 34.8 38.2 27 15.7 24.7 -never consulled before 29 41.4 38 20.6 6.8 3.4 -consuled in the past 60 31.7 38.3 30 20 35 Investigated pa0ents 131 46.6 32.8 20.6 10.7 46.6 -Nornal rwnor findings 64 45.3 35.9 18.8 12.5 48.4 -Rellux oesophagiis (RO) 19 21 58 21 15.8 68.4 -Peptic uler (PU) 39 61.5 12.8 25.6 7.7 33.3 -Bo* RO and PU 9 44.4 44.4 11.1 0 44.4EP-=Epigasbtc pan; HR=Heaium &/or regurgsla0on; Mixed=b EP and HR] Conclusions Patients >45 years accounted for much of the workload (68%), and new patients were uncommon.EP and HR often co-existed (23%).Most patients had consulted previously, 60% had had at least one investigation (often many years ago) with 49% having normal minor findings only.ASDs were already being taken by 38% of patients, and NSAIDs by 13%.These findings have important implications for developing viable dyspepsia guidelines.W2 Al W3 W4A randomised controlled trial of pre endoscopy screening for H. pylori in the management of dyspepsia.
The radiologic manifestations of blunt chest trauma
Authors: J. F. Wiot
Journal: JAMA (1975)

APPROXIMATELY one half of the deaths from auto accidents result either directly or indirectly from thoracic injury.<sup>1</sup>Serious injury to the thoracic contents may exist with absent or mild symptoms, and therefore, a careful radiologic investigation of the thorax is important in all patients with known chest trauma or those involved in serious accidents, whether or not they have chest symptoms. Thoracic injuries range from such relatively unimportant problems as simple rib fracture to great-vessel laceration, which, if not recognized and treated promptly, will almost certainly result in the death of the patient. Fortunately, the roentgenogram will demonstrate most of the significant injuries. In this presentation, discussion of injuries to the heart and great vessels will be omitted. <h3>Thoracic Cage</h3> Injury to the thoracic cage is similar to that of the skull in that the state of the bony framework tells little about damage to the underlying viscera. Fractures
Cell Calcium, Cell Injury and Cell Death
Authors: Benjamin F. Trump, Irene K. Berezesky, Toshihide Sato, Kauno U. Laiho, Patricia C. Phelps, Nicholas DeClaris
Journal: Environmental Health Perspectives (1984)

The role of calcium in cell injury has been the subject of much recent investigation. The movement and redistribution of this cation from extra to intracellular compartments and the calcium shifts between intracellular compartments may well play a determinate role in the cell's reaction to injury. Therefore, data of such shifts and their correlation with morphological, biochemical and cytoskeletal studies will provide a better understanding of these processes. To study the effects of calcium regulation on acute lethal anoxic injury and the effects of inhibition of respiration with cyanide, three experimental systems were utilized: Ehrlich ascites tumor cells, isolated rabbit proximal tubule segments and suspended or cultured rat proximal tubule cells. Although our data showed no correlation between total cell calcium and cell death except in highly selected cell systems, they did indicate that calcium can be an important control variable. Therefore, massive increases in total cell calcium, as seen in Ca3(PO4)2 precipitation in mitochondria, must be a secondary event and represent the modern day equivalent of the classical dystrophic calcification seen by pathologists in the past. Although the involvement of extracellular calcium in cell death may well be significant in some cell types, redistribution of calcium within the intracellular compartments may play an even more important role.
Selenium may act as cancer inhibitor
Authors: P. Gunby
Journal: JAMA (1981)

Mysterious, metallic selenium—17th in abundance among the earth's elements, potentially poisonous in some compounds, yet apparently essential to human health—has been cast over the years as both "hero" and "villain" among the trace substances. Now, another heroic role seems to be in the offing. Recent research reports spotlight selenium as a likely inhibitor of preneoplastic changes. One of the latest of these reports is from Daniel Medina, PhD, professor of cell biology, Baylor College of Medicine, Houston. He told an American Cancer Society seminar in Daytona Beach, Fla, that if introduced early in the process, selenium can inhibit virally or chemically induced tumorigenesis in animals. Medina cautions that until more is known about selenium toxicity levels in humans, "it is not recommended that people buy and consume this mineral as a prophylactic measure without any idea of how much they are taking. Chronic toxicity is possible because selenium is widely
Motor nerve conduction velocity in systemic diseases
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: J. PETERSON, H. OZER
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Chronic Myelogenous Leukemia: Molecular Approaches to Research and Therapy A. B. Deisseroth , R. B. Arlinghaus , eds. New York : Marcel Dekker, Inc. , 1991 , 481 pp. $135. JHON PETERSON, JHON PETERSON Division of Medical Oncology University of North Carolina School of Medicine3009 Old Clinic Bldg. CB No. 7305 Chapel Hill, NC 27599 Search for other works by this author on: Oxford Academic PubMed Google Scholar HOWARD OZER HOWARD OZER Division of Medical Oncology University of North Carolina School of Medicine3009 Old Clinic Bldg. CB No. 7305 Chapel Hill, NC 27599 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 19, 2 October 1991, Pages 1413–1414, https://doi.org/10.1093/jnci/83.19.1413 Published: 02 October 1991
Child neurologists wait for better evidence
Authors: None The Lancet Neurology
Journal: The Lancet Neurology (2007)

Reports of randomised clinical trials normally raise debate among practitioners and a flock of correspondence to medical journals. Two recent reports from the Standard and New Antiepileptic Drugs (SANAD) trial published in The Lancet were no exception. In this case, the trial's conclusions have been particularly challenged by paediatric specialists. The reason for their concern is that the trial included children over 4 years of age and adolescents, yet subgroup analyses for these specific populations were not reported in the articles.
Erratum
Journal: BMJ (1903)

JovlawiL 1903-~~~~~~~~~ forward a copy herewitlh: " I have argued strongly against the practice of bleeding, but tlhele is a method of abstracting a small quantity of blood dhrectly from the liver, wliol I should be inclined to try were I again in a position to deal with this disease in healthy subjects in India.On several occasions in this hospital I have had the following experience: We have had men admitted here with symptoms pointing to the existence of lhepatic abscess, with, at the same time, sharp local pain in tlle liver over well-defined limits; into such spots I have several times introduced the hollow needle of an aspirating syringe in the expectation of finding pus.On applying the syringe, instead of pus 5 oz.or 6 oz. of blood have been drawn off, with immediate relief of all the symptoms and without any unpleasant results.I have thus been led to think that in this way, at the sacrifice of a small quantity of blood in the acute stage of inflammation of the organ, we miight look for good results.I am sure of tlhis, that I lhave seen this small bleeding much more effective than the abstraction of twice or even three times as much from the integuments over the liver by leeches or cupping.I throw this out as a hint worlth trial in cases where the symptoms are so acute as to r-aise in youir minds a suspicion that the direct abstraction of blood might relieve pain and ward off the danger of suppuration."DIARRHOEA AND SURFACE WATER.
The Principles of Orthopedic Surgery for Nurses.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identifying Barriers to Implementation of Stock Epinephrine Bills: The Texas Experience
Authors: Chih-Yin Yeh, Anita Wheeler, Karen Schwind, Jannifer Fulbright, Douglas Jeffrey, Wesley W. Stafford, J. Andrew Bird, Pooja Varshney, Louise H. Bethea, Erika G. Gonzalez-Reyes, Theodore M. Freeman, Crystal Beard, Carla M. Davis
Journal: Journal of Allergy and Clinical Immunology (2018)
MENTAL DEFICIENCY AND PHENYLKETONURIA
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA-RPS Annual Meeting: Call for Resolutions
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal