tbuckley/cabot-search huggingface dataset:
A HANDBOOK ON THE PREVENTION OF CONSUMPTION.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuing Education Opportunities for Physicians September 1993 Through February 1994
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combined modality approaches to cancer therapy. Council on Scientific Affairs
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapy
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
Authors: X. Li
Journal: Journal of Clinical Investigation (2004)

The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
Mitochondrial oxidative metabolism contributes to maintain a cancer stem cell phenotype in cholangiocarcinoma
Authors: Chiara Raggi, Maria Letizia Taddei, Elena Sacco, Nadia Navari, Margherita Correnti, Benedetta Piombanti, Mirella Pastore, Jessica Iorio, Giulia Lori, Clelia Peano, Javier Cibella, Monika Lewinska, Jesper Andersen, Giovanni Di Maira, Matteo Ramazzotti, Ivan Orlandi, Paola Chiarugi, Fabio Marra
Journal: Journal of Hepatology (2020)
Progress, Prospects, and Research Needs on the Health Effects of Acid Aerosols
Authors: Morton Lippmann
Journal: Environmental Health Perspectives (1989)

Research on human exposure to acidic aerosols and the health effects of such exposures has substantially strengthened the hypothesis that such aerosols are a causal factor for excesses in human mortality and morbidity that have been previously associated with crude exposure indices such as British Smoke, total suspended particulate matter, and sulfur dioxide. Research reported at this symposium also showed that combined exposures to acid aerosols and other ubiquitous air pollutants such as O3, NO2, HNO3, and SO2 produce greater effects in both humans and animals than exposures to each agent separately. The responses reported ranged from physiological functions to lung structure. Furthermore, some of the effects were cumulative with increasing duration of daily exposure and number of repetitive exposures. Critical areas for further research include better definition of the critical temporal parameters affecting exposure and response, effects of mixed pollutant exposures, and pathogenetic mechanisms for acid aerosol-induced chronic lung damage.
Critical care medicine. The past and changes in the future
Authors: R. C. Bone
Journal: JAMA (1984)

Most recent innovations in medical sciences arose as a response to specific clinical problems. Examples include antibiotics for previously lethal pneumonia and tuberculosis. Intensive care had no such origins. The intensive care unit grew out of technological advances of the last decade. Physicians were presented with an enormous array of capabilities. In addition to the stethoscope and roentgenogram the physician could examine hemodynamics, expired air, gas contents, and respiratory physiological measurements. With previously lethal respiratory disease, the physician could intubate, ventilate, and resuscitate. An exciting new potential existed for patient care. Objective information could be obtained in real time and a trend analysis could be done. A physiological description of disease was possible that never before existed. But because intensive care medicine did not arise to fulfill a specific clinical need, such as penicillin for pneumococcal pneumonia, conditions that would clearly require the application of this advance were neither predetermined
AB0034 Activated neutrophils are able to efficiently produce interferon-alpha and retain this capability in systemic lupus erythematosus and rheumatoid arthritis patients
Authors: D. Lindau, A. Rabsteyn, J. Mussard, M. Ribon, I. Kötter, G. Adema, M.-C. Boissier, P. Decker
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Neutrophils play a pivotal role in inflammation and contribute to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) pathogenesis. Interferon (IFN)-α is involved in lupus development and might contribute locally to RA development. Activated plasmacytoid dendritic cells (pDC) are important producers of IFN-α but represent a minor cell population. On the other hand, neutrophils represent 50 % of total blood leukocytes. <h3>Objectives</h3> Although neutrophils are not considered as IFN-α-producing cells, we have investigated whether they may produce this cytokine and the stimuli involved. <h3>Methods</h3> PBMC and neutrophils were isolated from healthy individuals, SLE and RA patients. Mouse neutrophils were purified from the bone marrow. Cells were activated with different stimuli and IFN-α production/secretion was estimated by flow cytometry, ELISA and a bioassay. Neutrophil activation was verified by flow cytometry and ELISA. Gene expression was analyzed by qRT-PCR. Neutrophil extracellular trap (NET) induction was estimated by confocal microscopy. Chromatin, a major autoantigen in SLE also present in the synovial fluid of RA patients, was purified from calf thymus. We have actually previously shown that extracellular chromatin is pro-inflammatory. <h3>Results</h3> Isolated neutrophils produce IFN-α upon stimulation with Toll-like receptor (TLR) 9 and TLR7/8 agonists. IFN-α secretion by neutrophils was observed with neutrophils from both healthy donors and SLE and RA patients. Similar results were obtained with mouse neutrophils. IFN-α production by neutrophils was associated with IL-8, IL-6 and TNF-α secretion, CD66b up-regulation, ROS production and increased gene expression levels of IFN-α, IFN-β and IL-6. In low responders, PBMC sustain IFN-α secretion by neutrophils in co-cultures. Neutrophil priming is not required but GM-CSF acts synergistically with TLR9 agonists. Particularly, neutrophils respond to all types (A, B and C) of CpG-oligonucleotides. pDC are more efficient than neutrophils in producing IFN-α at the single cell level but this was largely compensated by the 200-fold excess of neutrophils in whole blood. Importantly, neutrophil-derived IFN-α was detected in response to free extracellular chromatin and was associated with NET formation (NETosis). <h3>Conclusions</h3> Neutrophils represent an important source of IFN-α. IFN-α was detected at the mRNA and protein levels and in an active and secreted form. Both normal as well as SLE and RA neutrophils produce IFN-α in response to specific stimuli. Therefore, neutrophils represent also important targets for future therapies aiming at influencing IFN-α levels. <h3>Disclosure of Interest</h3> None Declared
BJD Reviewers 2014
Journal: British Journal of Dermatology (2015)

British Journal of DermatologyVolume 172, Issue 4 p. 1165-1174 BJD Reviewers 2014 BJD Reviewers 2014 First published: 01 April 2015 https://doi.org/10.1111/bjd.13728Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume172, Issue4April 2015Pages 1165-1174 RelatedInformation
Publication of Summary of Notifiable Diseases, United States, 1992
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methadone maintenance. New research on a controversial treatment
Authors: R. M. Glass
Journal: JAMA (1993)

In a 1965<i>JAMA</i>article, Dole and Nyswander<sup>1</sup>presented an initial evaluation of what was then a new treatment for heroin addiction: methadone maintenance. These pioneering physicians recognized that drug-free treatments for opiate addiction were rarely successful, and that except for overdoses, the severe medical complications of heroin addiction were due to the hazards of unsterile injections rather than direct drug toxic effects. They reported that prescription of daily doses of methadone hydrochloride, a long-acting and orally effective synthetic opioid, could relieve craving for heroin and block its euphoric effects while creating a condition of pharmacologic stability that permitted psychosocial treatment and rehabilitation of patients whose lives had previously been dominated by their addiction. See also p 1953. The development of this medical treatment abetted the conceptualization of addiction as a disease, and increased the involvement of physicians in its treatment. However, methadone maintenance treatment was immediately controversial<sup>2</sup>
Histogenesis of Exocrine Pancreatic Cancer in the Hamster Model
Authors: Parviz M. Pour
Journal: Environmental Health Perspectives (1984)

There is strong evidence that induced pancreatic adenomas and carcinomas derive from ductal and ductular cells in the pancreas. We base our beliefs on our knowledge of the embryology and histology of the pancreas in Syrian golden hamsters, along with the sequential alterations that occur during exocrine pancreatic tumor formation. This concept also has been supported by much experimental evidence, including autoradiographic, immunologic and in vitro studies. We also present other viewpoints on the origin of pancreatic cancer histogenesis and outline certain areas of disagreement. We report the development of acinar cell lesions under certain experimental dietary conditions in hamsters (the lesions resemble those commonly seen in the rat pancreatic tumor model) and the nature of these lesions.
Erratum: “Telomere Length, Long-Term Black Carbon Exposure, and Cognitive Function in a Cohort of Older Men: The VA Normative Aging Study”
Authors: Elena Colicino, Ander Wilson, Maria Chiara Frisardi, Diddier Prada, Melinda C. Power, Mirjam Hoxha, Laura Dioni, Avron Spiro, Pantel S. Vokonas, Marc G. Weisskopf, Joel D. Schwartz, Andrea A. Baccarelli
Journal: Environmental Health Perspectives (2017)
Studies of Glioma Growth in Mice. II. Immunity After Excision
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In-flight medical emergencies. One year of experience with the enhanced medical kit
Authors: J J Cottrell, J T Callaghan, G M Kohn, E C Hensler, R M Rogers
Journal: JAMA (1989)

Recent regulations require commercial US aircraft to carry an enhanced medical kit. We reviewed kit use on United Airlines during the initial year of the regulations. We also surveyed passengers who became ill during flight and health care providers who used the new kit. The medical kit was used 362 times on 361 flights (once in every 1900 flights or one use for every 150,000 air travelers). Health care providers indicated that the kit was useful in more than 80% of emergencies and was occasionally lifesaving. In the emergencies in which the kit was used, 70% fell into one of seven major diagnostic groupings, including syncope/near syncope (29%), cardiac/chest pain (16%), asthma/lung disease/shortness of breath (10%), and allergic reactions (5%). With 450 million domestic air travelers per year, we would expect 3000 in-flight medical emergencies annually, and conclude that the enhanced medical kit is beneficial and propose that its effectiveness would be improved by the addition of a bronchodilator for inhalation.
AB0305 Potential in vitro immunomodulatory effects of the recombinant human alpha-enolase on peripheral blood mononuclear cells (pbmcs) from healthy donors.
Authors: C. Guillou, G. Avenel, C. Derambure, M. Verdet, M.-L. Golinski, M. Hiron, S. Adriouch, O. Boyer, T. Lequerré, O. Vittecoq
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Identification of autoantibodies associated with rheumatoid arthritis has been of major interest. In this context, we have previously identified for the first time α-enolase (ENO) as a new auto-antigen in early RA. ENO is an evolutionary conserved protein involved both in glycolysis pathway and as a plasminogen receptor which confer it a role in anti-infectious inflammatory response. In vivo, preliminary studies showed that ENO had immunomodulatory effect in the collagen induced arthritis mouse model<sup>1</sup>. <h3>Objectives</h3> To better understand the immunological mechanisms of ENO, the aim of this in vitro study was to determine the effects of ENO on PBMCs from healthy donors. <h3>Methods</h3> : In one hand, PBMCs or different cell types (monocytes, B and T cells, and immature dendritic cells [iDC]) (n=3) were cultured with ENO (20 µg/mL) or Bovine Serum Albumin (20 µg/mL). TNFα and IL-10 production was measured in the supernatants by ELISA at different times. On the other hand, TNFα and IL-10 production were evaluated in PBMCs, monocytes or B and T cells after LPS stimulation and pre-incubation with ENO for 24h (n=3). Cytometric analyses have evaluated the ability of ENO to inhibit the differentiation of monocytes into iDC or iDC into mature DC. Before differentiation into iDC (GM-CSF and IL-4), monocytes (1.106cells/mL) were incubated with ENO (20 or 50µg/mL) for 24h. <h3>Results</h3> In cultures of PBMCs, monocytes or iDC, ENO induces, dose dependently, an early production of TNFα followed by extended secretion of IL-10. PBMCs or individual cells (monocytes, B and T cells) stimulated by LPS secreted successively TNFα and IL-10, while PBMCs or individual cells, stimulated by LPS but previously incubated with ENO for 24h did not secrete these cytokines. In contrast to LPS, ENO did not induce differentiation of immature dendritic cells into mature cells. Moreover, ENO has the capacity to inhibit differentiation from monocytes to iDC. <h3>Conclusions</h3> This study suggests that ENO has no pro-inflammatory effect unlike LPS. Indeed, ENO might have immunomodulatory properties via IL-10 production. Others studies focused on an extended cytokine panel and different signaling pathways are underway to better understand the immunological mechanisms induced by ENO. <h3>References</h3> C. GUILLOU et al., Arthritis and Rheumatism 2011, 63:S815. <h3>Disclosure of Interest</h3> None Declared
Tenth annual AMA Science Reporters Conference focuses on variety of public health issues
Authors: A. A. Skolnick
Journal: JAMA (1991)

THE TENTH annual American Medical Association's (AMA) Science Reporters Conference began with discussion on "Funding Guidelines and Ethical Issues for Medical Broadcasters and Medical Education," led by members of the National Association of Physician Broadcasters. Among the insights elicited by the dialogue was the realization that physician reporters often have an agenda quite different from that of their nonphysician colleagues. While physician reporters generally seek to disseminate information that will promote public health, many lay reporters believe their role is to inform the public about the news, whether that news will be beneficial or harmful. The AMA conference, which was held in Atlanta, Ga, was cosponsored by the Centers for Disease Control (CDC) and Emory University School of Medicine, both on the outskirts of Atlanta. Not surprisingly, more than half the program was devoted to public health issues, ranging from lead poisoning to chronic fatigue syndrome to a demonstration of
MCAT responds to changes in medical education and physician practice
Authors: A. Swanson
Journal: JAMA (1989)

THE EXECUTIVE Council of the Association of American Medical Colleges has approved substantial revisions to the Medical College Admission Test (MCAT). Approximately every 10 years, the Association of American Medical Colleges undertakes a rigorous review of test format and content to ensure the MCAT's continuing timeliness, relevance, and fair and objective assessment. The current revisions are predicated on changes in medical education and medical practice to which the test must respond, rather than on any deficiencies in the current test. The knowledge base and technologies of medicine are changing and expanding at breathtaking speed. If tomorrow's physicians are to keep pace with the requirements of their profession, they will need the ability to gather and rigorously assess data, to apply the basic concepts and principles of medicine to the solution of scientific and clinical problems, to continually update their knowledge and skills, and to communicate what they have learned to