tbuckley/cabot-search huggingface dataset:
Basic Science: Medical Practice
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of the combined action of selenium and arsenic on suspension culture of mice fibroblasts
Authors: P Rössner, V Bencko, H Havránková
Journal: Environmental Health Perspectives (1977)

The protective influence of arsenic against the toxic action of selenium has been tested on suspension cultures of mice fibroblasts LA 115.The growth of the cells was observed after the isolated and combined action of sodium arsenite NaAsO2 and sodium selenite Na2SeO.The concentration range of both sub- stances in cultivation medium MEm (USOL) was 1O' -10-11M.The growth of treated cultures was analyzed daily during 5 days of exposure.From the results obtained, growth curves of the cell cultures were constructed and analyzed.The results of every determination were evaluated in relation to the corresponding control culture.The results obtained demonstrate that decreasing concentrations of arsenic enhanced its protective effect in the range of the concentrations used.In contrast, a low protective effect of selenium against arsenic was noted in the concentrations employed.The cell cultures have proved to be very suitable for toxicological studies of the combined effects of different substances.
Whither dialysis and renal transplantation?
Authors: B. T. Burton
Journal: JAMA (1974)

ABOUT a year ago, on July 1, 1973, the federal government activated a new law under which it assumed fiscal responsibility for the treatment of end-stage kidney disease in all patients covered by Social Security. This marks the culmination of a decade and a half during which two dramatic therapies for irreversible kidney failure have come to maturity: hemodialysis with artificial kidneys, and renal transplantation. Even though both cannot yet be regarded as optimal treatment modalities, they are probably here to stay as long as the nation is confronted with an annual toll of 60,000 uremic deaths. According to the National Dialysis Registry of the National Institutes of Health (NIH), the number of patients who are currently being maintained with the aid of chronic dialysis approaches 14,000. According to the American College of Surgeons/NIH Organ Transplant Registry, more than 8,000 renal transplants have been performed thus far in the United
Laboratory of Quantitative and Computational Biology
Journal: Environmental Health Perspectives (1993)

1~~fgfllI___NIEHS investigators have developed sensitive assays to detect susceptibility to carcinogens in cigarette smoke, foods, industrial by-products, and environmental pollution.Based on tests of more than 1000 individuals for these susceptibility genes, the frequency of the at-risk geno- types vary significantly among Asians, Caucasians, and African-Americans.Such variation suggests that some of the differences in cancer incidence among ethnic groups may be due to genetic differences as well as exposure differences.In collaboration with Jack Taylor of the NIEHS Epidemiology Branch, LBRA is testing the effect of certain cancer susceptibility genes in studies of bladder cancer, lung cancer, and liver cancer.In- dividuals who carry the at-risk genotype for glutathione transferase i, an enzyme that detoxifies constituents of cigarette smoke, suffer a 70% increased risk of blad- der cancer.In ongoing studies with researchers at the National Cancer Institute, Columbia University, University of North Carolina, and University of Keele, England, NIEHS is exploring how genetic variability in the metabolism of carcino- gens affects risk for cancer of the bladder, lung, liver, stomach, colon, head, and neck.The cytochrome P450 enzymes cat- alyze the oxidation of drugs, carcinogens, and other xenobiotics.Joyce Goldstein's group in LBRA is looking for genetic defects in these enzymes that affect the ability of humans to metabolize chemical agents.Population studies have shown that some people are poor metabolizers of the drug S- mephenytoin, and defective metabolism is inherited.Metabolism of other drugs, including barbiturates, the antimalarials, and the antiulcer drug omeprazole, may be mediated by
Animal Experimentation
Authors: Donald F. Phillips
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE INSANITY PLEA IN CRIMINAL TRIALS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Current Comment
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Collected Papers of St. Mark's Hospital, London, Including a History of the Hospital: Centenary Volume, 1835-1935
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: a report from the Nordic Bone Marrow Transplantation Group
Authors: O Ringden, T Ruutu, M Remberger, J Nikoskelainen, L Volin, L Vindelov, T Parkkali, S Lenhoff, B Sallerfors, P Ljungman
Journal: Blood (1994)
Call for Participants
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interspersed Advertising
Authors: Ivan Heisler
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Several communications with officers of the American Medical Association and the chief editor of the<i>Archives of Psychiatry</i>regarding the matter of pagination in AMA journals, ie, permitting obverse sides of pages to carry scientific material and advertising, have not yielded satisfactory answers to the questions that I raised. This practice compels the binding of journals with advertising matter included. Perusal of a number of journals from this country and abroad indicates that this practice is limited to the AMA journals! Quite a few colleagues have raised objection to this practice, and thus far it has not been openly acknowledged or corrected. I believe it essential that you publish this letter to encourage a wider membership to offer their views.
American Surgeon, Baltimore
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Remarks on Obstruction of the Bowels: With Cases
Authors: E. Copeman
Journal: BMJ (1861)

made a section with the iris knife, but she was but little improved.Two years afterwards I extracted the left cataract and she did well, and now (four years since) I hear that she has very good sight.CASE CCXXVII.M., aged 08.I operated on the right, and he recovered well with good sight.CASE CCXXVM.M., aged 71.(This case has been published at greater length in the JOURNAL of May 3rd, 1856.)On making the corneal section in the left eye and trying to extract the cataract, it fell backwards into his eye and remained invisible.He recovered his sight for a time, and as the right eye gradually became more dim, the amount of vision which he retained in the left was more valuable.I afterwards extracted the right cataract, and he recovered well and had good sight.CASE CCXXix.F., aged 71.I operated on the left eye, and she did well, and now (five years after) has good sight, but the pupil is a little distorted.CASE ccxxx.F.
Shelter and Indoor Air
Authors: Jan A. J. Stolwijk
Journal: Environmental Health Perspectives (1990)

Improvements in outdoor air quality that were achieved through the implementation of the Clean Air Act accentuate the quality of the indoor air as an important, if not dominant, factor in the determination of the total population exposure to air contaminants. A number of developments are adding important new determinants of indoor air quality. Energy conservation strategies require reductions in infiltration of outdoor air into buildings. New materials introduced in the construction and in the maintenance of buildings are contributing new air contaminants into the building atmosphere. Larger buildings require more and more complex ventilation systems that are less and less under the individual control of the occupants. All of these factors contribute to the current reality that indoor air contains more pollutants, and often at higher concentrations, than outdoor air. Especially in the larger buildings, it will be necessary to assure that an adequate quantity of fresh air of acceptable quality is provided to each individual space, and that no new sources of pollutants are added to a space or a whole building without appropriate adjustments in the supply of fresh air.
EDITORIAL CHANGE.
Authors: John B. Hamilton
Journal: JAMA (1893)

As heretofore announced,Dr. J. C. Culbertson, for the past two years editor of this journal, has returned to Cincinnati and resumed editorial management of the<i>Lancet and Clinic</i>.The Journaleditorial staff and the employés of the office extend to him their best wishes for his continued success. The undersigned has been elected editor, and therefore tendered his resignation as trustee July 1, 1893.
Transforming growth factor-beta1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction
Authors: Yoshitaka Isaka, Michiko Tsujie, Yutaka Ando, Hiroyuki Nakamura, Yasufumi Kaneda, Enyu Imai, Masatsugu Hori
Journal: Kidney International (2000)
Abstract 2343: Immunogenetics of cancer and aging
Authors: RMichael Williams, Edmond J. Yunis
Journal: Cancer Research (2019)

Abstract Antigen altered idiotype regulates specific immune responses (Cell Immunol. 1978: 4). Mendelian segregation of a given +/- phenotype defines an immune response gene (Benacerraf, Nobel). Autoimmunity producing anti-self clones must be eliminated or specifically suppressed, so a large portion of the antigenic repertoire resembles allogeneic MHC molecules (Medawar, Nobel). We proposed that exposure to many different allogeneic HLA molecules could cause specific immune suppression within the repertoire of epitopes and that these blank spots or holes in the universe of target antigens eventually would overlap with specificities including targets for eliminating pathogens such as viruses or tumor antigens. Some "holes" become large enough to result in an acquired immunodeficiency syndrome (AIDS) The opposite is also possible (Allogeneic Effect, Transplant Rev. 1972, 12; 141). This requires viable cells and cytokines released by host and/or donor. IR-genes for tumor resistance localize to the MHC. Class I/II MHC genes (Cancer Res. 1982; 35:1586) and NK cell receptor ligands (J. Stem Cell Res. 2007), regulate adaptive and innate immunity. We examined the combination of HLA specificities and the alleles of ligands of receptors of NK cells in breast cancer patients, HIV non progressors, and centenarians in Mexico. Immunological evaluation (CD4+,CD8+,CD19+ &amp; NK cells and quantitative IgM, IgG, &amp; IgA in breast cancer (BCA) patients in California. Overall survival (OS) depended on specificities (idiotypes) and the regulation of innate and adoptive immunity. The BCA patients and centenarians did not have HIV infection. People with more CD4 cells, more NK cells and more IgG, survive longer than those with the opposite immune profile. The immune specificity repertoire has evolved to avoid fatal autoimmunity, all orchestrated by T regs via T-cell antigen receptors and variable regions of Ig. The antigen receptors (CAR-T) and Ig variable region antigen receptors (Jerne, Nobel) are idiotypes, Single amino acid (AA) changes become altered "antigens" of the history of the patient: environment (e.g., microbiome), vaccination (e.g., BCG), and virus infections (Sendai or CMV in mice, HIV and/or others like HPV in man). This is true for single AA changes in both mice (H-2 mutants) and man; NK cell receptor ligands (Thr v Met). The results show profound effects on survival. Data, including MHC and NK receptor ligand phenotypes, OS and immunological evaluation of patients/people will be presented. Immunogenetic profiles of cancer survivors and long lived individuals are similar to those of HIV long term non progressors. Our data support our Immunogenetic Theory of Cancer and Aging. Citation Format: RMichael Williams, Edmond J. Yunis. Immunogenetics of cancer and aging [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2343.
Cancer in the Medical School Curriculum1
Journal: JNCI Journal of the National Cancer Institute (1947)

Cancer in the Medical School Curriculum Get access the National Advisory Cancer Council the National Advisory Cancer Council Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 8, Issue 1, August 1947, Pages 1–6, https://doi.org/10.1093/jnci/8.1.1 Published: 01 August 1947 Article history Received: 25 June 1947 Published: 01 August 1947
P101 Systemic and local IL-17A and miR-155 levels in rheumatoid arthritis patients
Authors: R Shumnalieva, D Kachakova, T Velikova, S Monov, R Kaneva, Z Kolarov
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Career situation of first and presenting author</h3> Assistant. <h3>Introduction</h3> Interleukin 17<b> (</b>IL-17) is a proinflammatory cytokine, which overproduction promotes the autoimmune reaction in rheumatoid arthritis (RA). Posttranscriptional regulation of IL-17 by specific microRNAs (miRNAs) is of great interest in the recent years. Studies have shown that miR-155 enhances Treg and Th17 cells differentiation and IL-17A production by directly targeting the suppressor of cytokine signaling (SOCS) 1.<sup>1 2</sup> <h3>Objectives</h3> To examine a possible deregulation of the expression levels of miR-155 and levels of IL-17A in peripheral blood (PB) and synovial fluid (SF) of RA patients. <h3>Methods</h3> Expression levels of miR-155 were determined in matched PB and SF samples of RA patients by relative quantitation method 2<sup>-ΔΔCt</sup>. As reference control for normalization RNU6B gene was used. Receiver operating characteristic (ROC) curve analysis using RQ values was constructed in order to evaluate the diagnostic accuracy of miR-155 in PB and SF for distinguishing RA patients from healthy controls (HCs). Concentrations of IL-17A in matched serum and SF samples were determined by Human IL-17A ELISA kit (Gene probe, Diaclone). The results were compared to HCs as well as within the RA group. <h3>Results</h3> miR-155 was overexpressed in 79.17% of RA SF (p=1.63 × 10<sup>-4</sup>) when compared to HCs SF. The ROC curve analysis showed diagnostic accuracy for miR-155 in SF with AUC=0.858 (95 CI: 0.757÷0.959) with 81.3% sensitivity and 81.8% specificity (p=2.3 × 10<sup>-4</sup>). SF levels of miR-155 were overexpressed in 76.09% of the RA patients compared to its systemic levels. Levels of IL-17A were higher in RA SF compared to serum (8.645 pg/ml versus 0.315 pg/ml, p=0.012). <h3>Conclusions</h3> The difference between the systemic and local levels of miR-155 and IL-17A in RA patients shows that the inflammatory process leads to their deregulation with a possible role of both molecules in the disease pathogenesis. The higher local levels of miR-155 and IL-17A confirm the data about the possible role of miR-155 in regulating the production of IL-17. <h3>References</h3> Khan D, Ansar Ahmed SA. Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs. <i>Front Genet</i> 2015;6:236. Yao R, Ma YL, Liang W, Li HH, Ma ZJ, Yu X. <i>et al</i>. MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. <i>PLoS ONE</i> 2012;7(10):e46082. <h3>Acknowledgements</h3> The study was supported by Grant 60/2013 and Grant 61/2015 from Medical University-Sofia, Bulgaria. <h3>Disclosure of Interest</h3> None declared.