tbuckley/cabot-search huggingface dataset:
New Translocations in Human Lymphocytes: A Mutagen Monitoring System
Authors: Frederick Hecht, Barbara Kaiser McCaw, David Peakman, Arthur Robinson
Journal: Environmental Health Perspectives (1979)

The human lymphocyte is a premier cell for monitoring chromosome aneuploidy. The lymphocyte is easily obtained, can be studied before and after culture, and has been extensively investigated. Assays available for lymphocytes include the scoring of chromosome breaks (subjective and laborious), the analysis of chromosome abnormalities such as increase or decrease in number (versus normal background), dicentrics etc., and the micronucleus test (presumable end-state phenomena). We propose the monitoring of somatic chromosome translocations in human lymphocytes. Background data available from North America indicate that the frequency of de novo chromosome translocations in Halifax, Portland, Denver, and Atlanta is about 1.7 x 10(-3). The most common translocation arising in lymphocytes is between chromosomes 7 and 14 (with a frequency of 4 x 10(-4). All translocations occurring de novo in human lymphocytes tend to appear balanced with no evidence for loss or gain of chromosome material. Cytogenetic laboratories are processing lymphocytes daily. The resultant photographs and karyotypes are all scorable for de novo translocations. Suitable data on exposure to possible mutagenic agents could be collected in advance of these chromosome studies. This would provide a new method for monitoring chromosome changes in the population. The cost of monitoring lymphocyte chromosomes for somatic translocations would be small, since numerous laboratories study lymphocytes rountinely for clinical diagnostic purposes. There may be merit in availing ourselves of easily available data from a very available species: man.
Target: sexually transmitted diseases
Authors: M. F. Goldsmith
Journal: JAMA (1990)

LOCAL LIQUOR merchants will soon be dispensing advice about disease prevention along with pints of vodka if a pilot intervention program just started by the Centers for Disease Control (CDC), Atlanta, Ga, proves effective. Seeking to make serious cuts in the ever-rising incidence of sexually transmitted diseases (STDs) in the nation's inner cities, the CDC is "reorienting its prevention and treatment programs in a major way," according to Willard Cates, Jr, MD, director of the agency's Division of Sexually Transmitted Diseases. One aspect of the proposed multifaceted approach involves community demonstration projects that have been devised by Kevin O'Reilly, PhD, and CDC colleagues to stop transmission of the human immunodeficiency virus (HIV). These are one of four large groups of projects the group handles. "If these interventions work," says Cates, "that will not only help reduce HIV transmission, but they'll have spin-off effects in showing how we can also reduce
Long-term outcome of coronary stenting: 8- to 10-year follow-up after palmaz-Schatz stent implantation in 426 consecutive cases Remi Choussat, Catherine Klersy, Alexander Black, Christian Jordan, Jean-Pierre Laurent, Bernard Cassagneau, Jean Fajadet, Jean Marco. UCI, Clinique Pasteur, Toulouse, France
Journal: Journal of the American College of Cardiology (2001)
The splicing regulator SLU7 is required for DNMT1 protein stability and DNA methylation maintenance
Authors: Miriam Recalde, María Gárate-Rascón, Maddalen Jimenez, María Elizalde, María Azkona, Marina Bárcena-Varela, Leticia Colyn, Maria U. Latasa, Iker Uriarte, Maite G. Fernandez-Barrena, Matías A. Avila, Maria Arechederra, Carmen Berasain
Journal: Journal of Hepatology (2020)
Predictive factors of response to interferon-? (IFN) in chronic hepatitis C: What factors for what response? Departments of 1Bacteriology-Virology, 2Epidemiology, 3Hepatology-Gastroenterology, H�pital Henri Mondor, Universit� Paris XII, Cr�teil, France; 4Roche Laboratories, Neuilly/Seine, France
Journal: Hepatology (1995)
Intraperitoneal Chemotherapy for Ovarian Carcinoma: Results of Long-Term Follow-Up
Authors: Richard R. Barakat, Paul Sabbatini, Dharmendra Bhaskaran, Margarita Revzin, Alex Smith, Ennapadam Venkatraman, Carol Aghajanian, Martee Hensley, Steven Soignet, Carol Brown, Robert Soslow, Maurie Markman, William J. Hoskins, David Spriggs
Journal: Journal of Clinical Oncology (2002)

To determine long-term survival and predictors of recurrence in a retrospective cohort of patients with epithelial ovarian cancer treated with intraperitoneal (IP) chemotherapy.Records were reviewed of 433 patients who received IP therapy for ovarian cancer between 1984 and 1998; follow-up data were available for 411 patients. IP therapy was provided as consolidation therapy (n = 89), or for treatment of persistent (n = 310) or recurrent (n = 12) disease after surgery and initial systemic therapy; therapy usually consisted of platinum-based combination therapy. Statistical analysis included tests for associations between potential prognostic factors, and between prognostic factors and survival. Survival probabilities were estimated by Kaplan-Meier methods, and prognostic factors for survival were evaluated by a Cox proportional hazard model.The mean age of patients was 52 years (range, 25 to 76 years). Distribution by stage and grade was as follows: stage I, 7; II, 24; III, 342; IV, 52; not available (NA), 8; and grade 1, 30; 2, 99; and 3, 289; NA, 15. The median survival from initiation of IP therapy by residual disease was none, 8.7 years; microscopic, 4.8 years; less than 1 cm, 3.3 years; more than 1 cm, 1.2 years. In a multivariate analysis, the only significant predictors of long-term survival were grade and size of residual disease at initiation of IP therapy.Prolonged survival was observed in selected patients receiving IP platinum-based therapy. It is not possible to determine the contribution of IP therapy to survival in this study. A relationship between size of disease at the initiation of IP therapy and long-term survival was demonstrated.
THE SPECIFICITY OF THE TYPHOID BACILLUS.
Journal: JAMA (1904)

Although at the present time we are generally ready to accept without question the idea that the typhoid bacillus is the sole cause of typhoid fever, because of the enormous amount of evidence of various sorts that has accumulated pointing to this view, yet there has always been one weak point in the evidence. The first two of the postulates of Koch that should be fulfilled by an organism before it can be fully accepted as the cause of a given disease have been abundantly satisfied, namely, that the organism must be found constantly present in the disease, and that it must be recovered in pure cultures from the diseased tissues. The third requirement, that the germ produce in an experimental animal the same lesions as are characteristic for the disease in man, has been the stumbling block. Inoculation into animals usually results in the development of acute degenerative changes
A Phase I-II Study Of The Efficacy and Safety Of Lenalidomide (LEN) Combined To Azacitidine (AZA) In Higher Risk MDS and AML With Del 5q – A Study By The Groupe Francophone Des Myelodysplasies (GFM)
Authors: Lionel Ades, Christian Recher, Aspasia Stamatoullas, Krimo Bouabdallah, Jacques Delaunay, Francois Dreyfus, Norbert Vey, Benoit de Renzis, Emmanuel Raffoux, Françoise Isnard, Benedicte Samey, Cendrine Chaffaut, Sylvie Chevret, Pierre Fenaux
Journal: Blood (2013)
Viral hepatitis
Authors: Tsuneo Ozeki, Takahide Nakamura'
Journal: Gut (1993)

Now,.the infection experiment of hepatitis C virus(HCV) has sueceeded in only the serum innoculation of patient with hepatitis(typeC) to Chimpanzees.Therefore, the study of virological aspect of HCV has scarcely greatly proceeded.We report a successful infection and culture of HCV by using a Chang cell culture.
Resolutions Affecting Graduate Medical Education
Journal: JAMA (2000)

many different specialties met at the AMA's Interim Meeting in San Diego, Calif, on December 2-4, 1999, to discuss issues of mutual interest.Resolutions pertaining to graduate medical education (GME) and public safety were among the key topics.The following summarizes some of the resolutions that the delegates adopted.Impact of Changing Resident Employment Status asks the AMA to prepare a report on the potential impact of the National Labor Relations Board's (NLRB) ruling that residents are employees.While many residents under-
Three Lectures on Some Points Relating to Injuries to the Head
Authors: W. H. Battle
Journal: BMJ (1890)

I have mentioned Porro's and Sdnger's methods of sterilising the%mother, as well as saving the'child, but 1'can conceive it' pOs- sible that, if the time should come, as come it will in the3 opinion of some eminent experts, when the mortality of CQsarean section is reduced to 10 per cent., or lefs, a case may now and then occur in which this steriisation should not be carried out.Let us ima- gine that a nobleman's wife or a person of great estate, by whom judging by the usual motives of human conduct-much would be endured in order to provide an heir to the title or estate, the mother might elect to encounter the repeated risk of Cesarean section until a son and heir was born.These various questions however, which I have opened and not attempted to decide, may well be left to time and experience to settle; there is no discredit but rather merit attaching to this avowed uncertainty, for I hold that suspense of judgment and an open mind become a duty, while evidence is conflicting and ex- perience accumulating.
Meetings of Medical Interest
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HGG-03. INTEGRATED MOLECULAR AND PATHOLOGICAL CHARACTERISATION OF NON-BRAINSTEM PAEDIATRIC HIGH GRADE GLIOMA FROM THE HERBY PHASE II RANDOMISED TRIAL
Authors: Alan Mackay, Anna Burford, Valeria Molinari, David Jones, Daniel Rodriguez, Paul Morgan, Stefan Pfister, Thomas Wurdinger, Rachel Tam, Meghna das Thakur, Josep Garcia, Gilles Vassal, Jacques Grill, Tim Jaspan, Pascale Varlet, Chris Jones
Journal: Neuro-Oncology (2017)

The HERBY trial was a phase-II open-label, randomised, multicentre trial evaluating bevacizumab in patients with newly-diagnosed non-brainstem high grade glioma (HGG) between the ages of 3-18yrs. 121 patients were randomised with 1yr event-free survival as the primary end-point. Confirmation of HGG diagnosis by reference pathology was mandatory before randomisation, followed by review with five independent expert neuropathologists. We collected specimens from 89 patients consenting to translational research, and performed Sanger sequencing for H3F3A, Illumina 450K BeadArray methylation profiling, and whole exome sequencing and RNA sequencing where possible. 7/89 patients (8%) harboured H3F3A G34R/V mutations, whilst 24/89 (27%) harboured H3F3A K27M, the latter reflecting a high proportion of the novel entity recognised in the 2016 WHO classification of diffuse midline glioma with H3K27M mutation. Both histone mutations conferred a significantly shorter progression-free (p=0.0104) and overall survival (p=0.00159). 450K methylation subtyping additionally identified a number of subgroups in histone wild-type cases. These included infrequent (4/86, 4.6%) cases with IDH1 mutation in older children, further categorised into astrocytic ATRX-mutant (n=3) or 1p19q co-deleted with TERT promoter mutation (n=1). 9/74, (12%) of cases were classified as biologically resembling pleomorphic xanthoastrocytoma (PXA) by methylation profiling, with 5/9 harbouring BRAF V600E mutations and epithelioid histology, and 3/9 NF1 mutation and giant cell features. Three cases had methylation profiles more closely resembling low grade gliomas, though were morphologically high grade, and harboured MAPK dysregulation in two cases, with the third part of an additional infant (<3yrs) cohort. Finally, four cases had a mutational burden several orders of magnitude higher than the rest, with 2197–5332 somatic coding variants/sample reflecting a hypermutator phenotype. These data provide an important insight into the wide biological diversity of ‘HGG’ found in the paediatric age group and allow for a profound refinement of clinical trial interpretation.
Ventricular tachycardia?
Authors: Beatrice Kühn
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

A 59-year-old patient presented with “suspicion of ventricular tachycardia” because of “abnormalities in the long-term ECG” (Figure. 1). Cryoablation of the slow path had already taken place beforehand, in the case of slow-fast atrioventricular nodal reentry tachycardia.
International Conference on the Occupational and Environmental Significance of Chemical Carcinogens
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article International Conference on the Occupational and Environmental Significance of Chemical Carcinogens Get access JNCI: Journal of the National Cancer Institute, Volume 74, Issue 6, June 1985, Page 1365, https://doi.org/10.1093/jnci/74.6.1365 Published: 01 June 1985
Safety and feasibility of the IVUS-balloon megasonics catheter: A multicenter investigation Alexandre Abizaid, Andrea S. Abizaid, Ibraim M. Pinto, Marco A. Costa, Rodolfo Staico, Fausto Feres, Luiz A. P. Mattos, Marinella Centemero, Luiz F. L. Tanajura, Aurea Chaves, Ana C. Seixas, Hugo Londero, Amanda G. M. R. Sousa, J. Eduardo M. R. Sousa. Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil
Journal: Journal of the American College of Cardiology (2001)
Renovascular hypertension: diagnostic problems and therapeutic implications
Authors: J. L. Izzo
Journal: JAMA (1983)

Recent experiences with the angiotensin II (A II) receptor blocker sarcosine-1 alanine-8 angiotensin II (saralasin)<sup>1</sup>and the angiotensin-converting enzyme (ACE) inhibitor captopril<sup>2</sup>have served to reemphasize the importance of the renin-angiotensin axis in cardiovascular homeostasis. In this issue ofThe Journal(p 368), Fouad and her colleagues report that another A II receptor blocker, sarcosine-1 threonine-8 angiotensin II ([Sar<sup>1</sup>, Thr<sup>8</sup>]A II), is not superior to saralasin in predicting the response of renovascular hypertension to surgical correction. However, despite the fact that depressor responses to angiotensin blockers are not specific for renovascular hypertension, it would be a mistake to assume that interruption of the renin-angiotensin system is not a useful diagnostic or therapeutic measure. Correct interpretation of various BP responses to reninangiotensin interruption is sometimes difficult but generally possible. Despite some controversy, the most important overall determinant of response to renin-angiotensin blockade is the baseline activity
Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant hepatitis
Authors: I Chemin
Journal: Hepatology (1996)

The objective of this work is to examine the possible modulation of carcinogen metabolism (activation by cytochrome P450s and detoxification by conjugation via glutathione S-transferases [GST]) in relation to hepatitis B virus (HBV)-associated liver injury. In HBV transgenic mouse lineage 107.5, the hepatitis B surface antigen (HBsAg) is expressed at noncytopathic concentrations but after injection of an HBsAg-specific, major histocompatibility complex (MHC) class I restricted cytotoxic T-lymphocyte (CTL) clone, the mice develop a severe acute necroinflammatory liver disease that reaches maximum severity within 3 days and gradually subsides during the next 2 to 3 weeks. In this model, using immunohistochemical analysis, we observed an increase of P450s (CYP1A and 2A5), both involved in aflatoxin B1, metabolism, but minor changes or no changes for others (2B, 2C, 2E, 3A). There was a fivefold decrease in the total liver P450 microsomal content 3 days' post-CTL injection with the result that the relative proportion of CYP2A5 and 1A compared with other P450s is increased. Individual microsomal P450 enzyme contents estimated by Western blotting; Northern blot analysis of liver CYP messenger RNA (mRNA) levels as well as in vitro metabolism of specific substrates for different P450 isoenzymes were consistent with the immunohistochemical data. Immunohistochemical staining with antibodies to cytosolic pi class GST was increased 1 and 3 days postinjection followed by a progressive decrease at later time points (the same phenomenon was observed to a lesser extent for GST α). The activity of hepatic cytosols toward substrates specific for different subclasses of GST (mu, pi, α) showed that while GST mu was not changed in the CTL-injected HBV transgenic mice, GST pi and, to a lesser extent, α were increased as compared with controls. These results suggest that liver cell injury induced by a process of acute fulminant-like hepatitis can lead to the induction of some carcinogen metabolizing enzymes notably, Cyp 1A, 2A5 and GST pi in the mouse.
异位性皮炎与手部湿疹之间的关联:一项系统综述与元分析
Authors: S.M.D. Ruff, K.A. Engebretsen, C. Zachariae, J.D. Johansen, J.I. Silverberg, A. Egeberg, J.P. Thyssen
Journal: British Journal of Dermatology (2018)

Summary 异位性皮炎(AD,一种常见的湿疹类型)是一种儿童皮肤病。它会引起剧烈瘙痒和皮肤干燥问题。大部分儿童和成人会在皮肤褶皱处(膝盖和手肘的弯曲处)出现湿疹,但一些成人患者的面部、手部和足部也会出现湿疹。传统的异位性手部湿疹(HE)出现在手背上,这可能是因为手背的皮肤比手掌部位要薄。然而,AD还会提高因刺激物(例如肥皂和水)而导致产生HE的风险,这就是所谓的“刺激性接触性皮炎”。这种子类型的HE通常最开始出现在手指之间或旁边的皮肤上,但随后可能会出现在手部的任何位置,包括手掌。重要的是,HE会妨碍人们的工作并降低他们的生活乐趣和质量。目前的研究旨在通过回顾已发布的文献和科学研究来寻找AD和HE之间的关联。在每项研究中,我们都会搜索与AD和HE之间的关联有关的数据。我们结合了26项研究的结果,在查看HE的一年和终身发病率(意思是,在某一年或到目前为止的人生中的任何时候患上HE的患者,即使患者目前已痊愈)时发现,当前或过去患有AD的患者患上HE的风险会提高3至4倍。在研究与当前HE的关联时发现了较弱的相关。而在研究在不同职业中因暴露在刺激物中而患上HE和一般人群中报告的HE时发现了类似的正相关。结论是,我们的分析表明,AD患者患上HE的可能性大大增加。临床医生应继续指导AD患者尽可能避免从事HE高风险的职业。此外,未来的研究还应关注于确定AD和不同类型的HE之间的关联的重要性。
Correction: Infection control revisited: dilemma facing today's bronchoscopists
Journal: BMJ (1988)

20L--X 10-0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 No of beds occupied per day FIG 4-Cumulative occupancy of beds in accident hospitalsix beds covers only 67% of the year and that to cover 95% of the year 10-12 beds would be required.It was recommended to the orthopaedic surgeons that district B needed 10-12 additional trauma beds to compensate for the closure of the accident hospital.The timing of this recommendation coincided with a review ofacute services by the region.Using bed norms and planning populations the region had estimated that district B was roughly 24 beds short for trauma and orthopaedic patients.The study therefore helped strengthen the case for additional beds for trauma and orthopaedics, and an extra ward is now planned for the specialty. Discussion
Lung Transplantation
Authors: Selim M. Arcasoy, Robert M. Kotloff
Journal: New England Journal of Medicine (1999)

Since the performance of the first successful lung transplantation nearly two decades ago, the procedure has gained widespread acceptance as a therapeutic option for a diverse array of lung diseases. For patients with severe functional impairment and limited life expectancy, lung transplantation offers the possibility of a markedly improved quality of life and longer survival. Nonetheless, complications are frequent and result in constraints on long-term preservation of graft function and patient survival. This article will review the current status of lung transplantation, with particular attention to the selection of patients, achievable outcomes, and complications.Recent TrendsAfter the initial technical . . .
Safeguards for plasma donors in plasmapheresis programs
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Participant Index
Authors: Aaberg Tm, Aiello Lp, Neili Ainsworth, Aitken Pj, Aizuss Pa, Akata Rh, Akova Rf, Rajhi Aa, Ai-Rashed Wa, Alanis Alexander, Alfonso Ec, Alldredge Oc, Allen Aw, Arend Ko, Arevalo Jf, Arnoldi Ka, Arterberry Jf, Arya Av, Buzney Sm, Byer Ne, Byrd Byrne, J Byrne, C Hm, Cakir Kv, Camara Jg, Campbell Dg, Campbell Rc, Campbell Rj, Caprioli Caputo, Cardillo Ar, Carvalho Ca, Cerri Gg, Cevalios Av, Chadwick Eg, Chaine Gj, Chalam Kv, Chan Ck, Chan Gh, Chandler Jw, Chandra Sr, Chang Ej, Chang Jr, Chang Kc, Chedid Sg, Costin Ja, Fattori Cm, Coupland Sg, Kohn Kohnen, Krishnadas Krivoy, Krohel Jl, Kroll Gb, Kuhn Fp, Kuliman Kulwin, Kumagi Dr, Kumar Ab
Journal: Ophthalmology (1995)