tbuckley/cabot-search huggingface dataset:
Meeting of Reticuloendothelial Society
Journal: JNCI Journal of the National Cancer Institute (1970)

Journal Article Meeting of Reticuloendothelial Society Get access JNCI: Journal of the National Cancer Institute, Volume 45, Issue 1, July 1970, Page 213, https://doi.org/10.1093/jnci/45.1.213 Published: 01 July 1970
Obituaries
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIPG-24. TARGETED INHIBITION OF JMJD3 AND BET BROMODOMAIN PROTEINS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS
Authors: Hiroaki Katagi, Nundia Louis, Xingyao He, Kathryn Loughlin, Ali Zhang, Patrick Ozark, Craig Horbinski, Rishi Lulla, Amanda Saratsis, Stewart Goldman, C David James, Ali Shilatifard, Rintaro Hashizume
Journal: Neuro-Oncology (2018)

Recent discovery of somatic histone gene mutations, resulting in replacement of lysine 27 by methionine (K27M) in the encoded histone H3.3 proteins, in diffuse intrinsic pontine glioma (DIPG) has improved our understanding of disease pathogenesis, and stimulated the development of novel therapeutic approaches targeting epigenetic regulators for disease treatment. K27M mutant DIPG shows a dramatic reduction in global methylation at K27 residues. We have shown that the JMJD3 demethylase inhibitor, GSKJ4, acts to restore K27 methylation in DIPG cells, while demonstrating potent anti-tumor activity, in vitro and in vivo. In addition to H3K27 methylation, H3K27 can also be acetylated (K27ac), which requires bromo- and extra-terminal domain (BET) protein activity. Increase level of H3K27 acetylation and bromodomain proteins in K27M-containing nucleosomes suggests that inhibitor of BET bromodomain protein 4 (BRD4), JQ1, could be useful for the treatment of K27M DIPG. Our aim is to investigate the hypothesis that the combined GSKJ4 + JQ1 have greater anti-tumor activity in vitro and in vivo than either monotherapy and reduce the likelihood of drug resistance. The level of H3K27 methylation and acetylation in DIPG cells with treated GSKJ4 + JQ1 were studied by western blotting. GSKJ4 + JQ1 increase H3K27 methylation and reduce K27acetylation in DIPG cells. Analysis on cell number showed that combination treatment of GSKJ4 + JQ1 significantly increases growth inhibition, compared with either therapy alone. In vivo response to monotherapy and combination of GSKJ4 + JQ1 will be measured by bioluminescence imaging and animal survival studies in human DIPG xenograft model.
Early Consolidation with Myeloablative Radiochemotherapy Followed by Autologous Stem Cell Transplantation in First Remission Significantly Prolongs Progression-Free Survival in Mantle Cell Lymphoma - Long Term Follow up of a Prospective Randomized Trial of the European MCL Network.
Authors: Martin H. Dreyling, Georg Lenz, Eva Schiegnitz, Achiel van Hoof, Christian Gisselbrecht, Michael Pfreundschuh, Bernd Metzner, Lorenz H. Truemper, Marcel Reiser, Hjalmar B. Steinhauer, Jean-Michel Boiron, Marc A. Boogaerts, Ali Aldaoud, Vittorio Silingardi, Hanneke C. Kluin-Nelemans, Joerg Hasford, Reza Parwaresch, Unterhalt Michael, Hiddemann Wolfgang
Journal: Blood (2004)
Normal Heart Sounds, Heart Size, Arterial Pressure, and Electrocardiograms from Infancy to Early Adulthood in One Man and One Woman
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INDISPENSABLE USE OF NARCOTICS
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mammographic Appearances
Authors: Franklin S. Alcorn
Journal: JAMA (1973)

Over the last five years, there have been approximately five monographs or atlases on the subject of mammography published in English. This book by a well-known French author reflects the different emphasis on mammography in the management of breast disease in Europe and the United States. These differences are most apparent in the chapter that discusses the mammographic appearance of primary neoplasms and the surrounding breast tissue, following curative radiotherapy. This modality of therapy is not commonly used in this country, but judging by the substantial amount of material, the author has apparently had considerable experience in following up these cases. The author describes and illustrates by serial mammograms the effects of radiation on various types of primary malignant neoplasms. The appearance of the recurrences and the importance of long-term, serial followup studies is emphasized. Roentgenographic follow-up is especially important, since the breast frequently becomes fibrotic, and physical examination is
Parasitism and Disease. By Theobald Smith
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minireview: Delivering the Code: Polyplex Carriers for Deoxyribonucleic Acid and Ribonucleic Acid Interference Therapies
Authors: R. James Christie, N. Nishiyama, K. Kataoka
Journal: Endocrine Reviews (2010)

Nucleic acid-based therapies offer great potential for treatment of a variety of diseases including cancer by modulating protein expression with DNA or small interfering RNA. However, realization of their full therapeutic potential is currently limited due to an inability to reach the target site intact in an active form. Identification of delivery barriers such as stability in circulation, resistance to degradation and entrapment in subcellular vesicles has led to development of sophisticated multifunctional synthetic polymers for forming ionic complexes with nucleic acids and also providing performance-enhancing features. The most promising designs comprise features to help increase stability in circulation and also contain functionality to aid in endosome escape of nucleic acid cargo after cellular internalization.
Maternal Depression and Child Development After Prenatal DHA Supplementation
Authors: Takefumi Suzuki
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methods used to quit smoking in the United States. Do cessation programs help?
Authors: M. C. Fiore
Journal: JAMA (1990)

Using data from the 1986 Adult Use of Tobacco Survey, we analyzed smoking-cessation methods used by adult smokers in the United States who tried to quit. About 90% of successful quitters and 80% of unsuccessful quitters used individual methods of smoking cessation rather than organized programs. Most of these smokers who quit on their own used a "cold turkey" approach. Multivariate analysis showed that women, middle-aged persons, more educated persons, persons who had made more quit-smoking attempts, and, particularly, heavier smokers were most likely to use a cessation program. Daily cigarette consumption, however, did not predict whether persons would succeed or fail during their attempts to quit smoking. Rather, the cessation method used was the strongest predictor of success. Among smokers who had attempted cessation within the previous 10 years, 47.5% of persons who tried to quit on their own were successful whereas only 23.6% of persons who used cessation programs succeeded. We conclude that cessation programs serve a small, but important, population of smokers that includes heavier smokers, those most at risk for tobacco-related morbidity and mortality. (<i>JAMA</i>. 1990;263:2760-2765)
Moricizine
Authors: Alastair J.J. Wood, Christopher A. Clyne, N.A. Mark Estes, Paul J. Wang
Journal: New England Journal of Medicine (1992)

MORICIZINE hydrochloride was first synthesized in the Soviet Union in 1964,1 2 3 and after pharmacologic and clinical evaluation in the United States4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 it was approved by the Food and Drug Administration in June 1990 to treat documented life-threatening ventricular arrhythmias. The drug (molecular weight, 464) is a phenothiazine derivative, with a carbamic ethol ester side chain attached to the second position of the phenothiazine ring (10-(3-morpholinopropionyl) phenothiazine-2-carbamic acid ethol ester hydrochloride) (Fig. 1). It is chemically unrelated to any currently approved antiarrhythmic drug,20 21 22 23 24 25 and despite having a phenothiazine structure, it lacks dopamine-antagonist activity and the behavioral and autonomic actions of neuroleptic . . .
SOLUBLE BACTERIAL TOXINS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adult Immunization: Knowledge, Attitudes, and Practices — DeKalb and Fulton Counties, Georgia, 1988
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive factors and prognostic significance of tumor regression grade in rectal cancer.
Authors: Oluwabunmi Ogundimu, Ravi Ramjeesingh, Kevin Ren, Melody Xuan Lu Qu, David Hurlbut, James Joseph Biagi, Aamer Mahmud
Journal: Journal of Clinical Oncology (2015)

739 Background: Several systems describe tumour regression grade (TRG) after neo-adjuvant chemo-radiotherapy (nCRT) in rectal cancer; however, there is lack of literature on factors predicting TRG and its prognostic significance when comparing two TRG systems. Methods: Chart review of 187 patients (pts) diagnosed with rectal cancer managed at our institution identified clinical T3 or T4 and/ or node positive adenocarcinoma who completed nCRT between 2005-2011. Assessment of TRG post-nCRT in 104 pts was determined using College of American Pathologists (CAP) and Modified Rectal Cancer Regression Grade (mRCRG) scoring systems. Logistic regression model was used to identify factors associated with TRG. Overall survival (OS) was estimated using Kaplan-Meier method, log-rank test to compare groups and Cox proportional hazard model to estimate hazard ratio. Results: Median age of 103 eligible pts was 64 (range [r] 31-88) and 70% were male. Median pre-nCRT tumour size was 4 cm (r 0.5-12). 61% tumours were distal. Radiation dose (RD) was &gt;54 Gy in 57%, 50.4 Gy in 40%, and 45 Gy in 3% patients. 71% received concomitant 5 FU; 12% capecitabine and 17% according to clinical trials prior to radical surgery. Median time between completion of nCRT and surgery was 49 days. CAP scoring was 0 (21%), 1 (7%), 2 (19%), and 3 (53%) whereas mRCRG scoring was 1 (31%), 2 (21%), and 3 (48%). With median follow up 5.04 years (yr), 5 yr OS was 65%. OS was 77% for CAP 0 and 1 vs. 59% for CAP 2 and 3 (p=0.0483, HR2.4); mRCRG 1 and 2 OS was 75% vs 54% for mRCRG 3 (p= 0.0060, HR2.6). &gt;30% reduction in pre-nCRT tumour occurred in 63% of CAP 1, 2, and 3 cases. Age (≥65 yr), higher RD and higher pre-op CEA were associated with mRCRG grade 3 (p=0.0339, 0.0415, and 0.0760 respectively). Tumour size, location, grade, type of chemotherapy, or gender were not predictive of TRG. Conclusions: Favorable TRG post-nCRT is associated with a statistically significant OS advantage. Younger age and RD escalation are associated with favorable TRG. CAP and mRCRG scoring systems of TRG were comparable for prognosis. nCRT leads to a significant cytoreduction in 63% of non-complete responders. TRG may have a future role in decisions on surgery, organ sparing, adjuvant chemotherapy, surveillance and patient counseling.
Lectures on the Anatomy of the Intestinal Canal and Peritoneum in Man
Authors: F. Treves
Journal: BMJ (1885)

number as twenty-five cae; that is, somewhat over 12 r oet.In the majority of these cases, it occurred in connection with pneumonia.It is almost always cortical, but may extend to the base and involve the nerves, leading in one case, which I saw with Dr. Ross at the Montreal Hospital, to strabismus, and also to ulceration of the cornea from involvement of the fifth nerve.In rare instances the spinal meninges are involved, and the clinical picture may be that of an
<i>Biographic Clinics</i>(Vols. IV and V); Essays concerning the Influence of Visual Function, Pathologic and Physiologic, upon the Health of Patients, by George M. Gould, M. D., editor of<i>American Medicine,</i>author of "An Illustrated Dictionary of Medicine," etc., etc. (Philadelphia: Blakiston's Son &amp; Co., 1907.)
Authors: H. O. R.
Journal: American Journal of Psychiatry (1907)
Persistent vegetative state and the decision to withdraw or withhold life support. Council on Scientific Affairs and Council on Ethical and Judicial Affairs
Journal: JAMA (1990)

Persons with overwhelming damage to the cerebral hemispheres commonly pass into a chronic state of unconsciousness (ie, loss of self-awareness) called the vegetative state. When such cognitive loss lasts for more than a few weeks, the condition has been termed a persistent vegetative state, because the body retains the functions necessary to sustain vegetative functions. Recovery from the vegetative state does occur, but many persons in persistent vegetative states live for months or years if provided with nutritional and other supportive measures. The withdrawal of life support from these persons with loss of higher brain function is a controversial issue, as highlighted by public debates and judicial decisions. This article provides criteria for the diagnosis of permanent unconsciousness and reviews the available data that support the reliability of these criteria. Significant legal decisions have been made with regard to withdrawal of life support to patients in persistent vegetative states, and the trends in this area are discussed.The clinical criteria for diagnosing the persistent vegetative state (PVS), i.e., permanent unconsciousness, are reviewed, and the reliability of diagnosis and remote possibility of recovery from this condition are evaluated. Legal trends relating to the role of physicians in deciding whether to refrain from providing ventilator or nutritional support in cases of PVS are discussed. Appended to the article are Sections 2.20 and 2.21, concerning withholding or withdrawing life-prolonging medical treatment, from the Current Opinions of the Council on Ethical and Judicial Affairs of the American Medical Association -- 1989.
Contemporary use of the disease concept
Authors: J. D. Sapira
Journal: JAMA (1978)

Six measures were used to assay the degree to which physicians endorsed the disease concept in their practice of ambulatory medicine. For each measure, two series of data were generated: one for patients receiving antihypertensive medication and one for patients receiving psychotropic medication. The disease concept was endorsed by only four of six measures for the patients receiving antihypertensive medication, and it was not endorsed by any of the six measures when patients receiving psychotropic medications were studied. Within the limits of this study, it is concluded that the disease concept is not generally endorsed by physicians. (<i>JAMA</i>239:1634-1637, 1978)
Unearthly medicine demands special devices
Authors: C. A. Raymond
Journal: JAMA (1988)

IT'S GOING to be some time before space physicians will be able to wave a hand-held box over their patients, à la "Star Trek's" Dr McCoy, and make a diagnosis. Yet, the tools NASA is developing for the Health Maintenance Facility have some of the flavor of science fiction, because they will need to be adapted to the conditions of micro-gravity. The core diagnostic component of the facility will include capability to do a complete blood count, urinalysis, clinical chemistry and electrolyte measurements, basic microbiology, and diagnostic imaging. Scientists in NASA's clinical laboratory have been working with private firms to adapt existing technologies to the space environment. Some of these technologies have already been used in space flights; some are being developed specifically for the space station. Hematologic analyses will be done by placing a sample into a coated capillary tube; the tube is centrifuged and the cells separate into