tbuckley/cabot-search huggingface dataset:
THE FREQUENCY OF TUBERCULOSIS.
Authors: A LUMIERE
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the North Dakota Medical Society, for 1897.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biopsy of occult breast lesions and professional liability
Authors: R. J. Darios
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LYMPHOBLASTIC ERYTHRODERMIA
Authors: JAMES H. SEQUEIRA, PHILIP N. PANTON
Journal: British Journal of Dermatology (1921)

Journal Article LYMPHOBLASTIC ERYTHRODERMIA Get access JAMES H. SEQUEIRA, M.D., F.R.C.P., F.R.C.S., JAMES H. SEQUEIRA, M.D., F.R.C.P., F.R.C.S. Physician, Skin‐Department, London Hospital Search for other works by this author on: Oxford Academic Google Scholar PHILIP N. PANTON, MB., B.CH. Cantab. PHILIP N. PANTON, MB., B.CH. Cantab. Director, Hale Clinical Laboratory, London Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 33, Issue 12, 1 December 1921, Pages 391–400, https://doi.org/10.1111/j.1365-2133.1921.tb09012.x Published: 01 December 1921
Epithelial cell death markers M65 and M30 are significantly up-regulated in decompensated liver cirrhosis and decreased by correction of portal hypertension
Authors: Beatrice-Victoria Jahn, Felix Piecha, Anja Koop, Thomas Horvatits, Adina Pfeil, Ansgar W. Lohse, Johannes Kluwe
Journal: Journal of Hepatology (2020)
Comparison of Renografin and Hypaque for Carotid Arteriography
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the basis of computed tomography and liver function
Authors: N Yamanaka
Journal: Hepatology (1993)

We compared liver volume and function kinetics after partial hepatectomy according to extent of resection and severity of coexisting liver disease in 57 adults with uneventful postoperative courses. Liver volume and massiveness of resection, or resection rate, were estimated on computed tomography. Patients were categorized into three groups on the basis of reaction rate: small (<30%), medium (30%-50%) and large (>50%). The regenerative patterns of normal livers in the medium and large groups consisted of three phases: a rapid increase during the first month, some decrease in the second month and a final, slower increase. This contrasted with the pattern of injured livers with chronic hepatitis or cirrhosis, which generally showed a phase of less rapid, gradual increase. The regeneration rate (volume gain, cm3/day) during the first month was found to be proportional to resection rate in the presence or absence of liver disease. Normal livers regenerated at least twice as rapidly as injured livers in patients with comparable resection rates. Normal livers reached plateau levels within 1 to 2 mo regardless of the massiveness of resection, whereas regeneration took 3 to 5 mo in injured livers. Liver function (albumin, bilirubin) recovered concomitantly with liver volume in the medium group, whereas in the large group they generally returned to their initial values behind volume restoration, particularly in cirrhotic patients. In conclusion, human liver regeneration is strongly influenced by the massiveness of the resection and presence of coexisting liver disease. However, we found that some cirrhotic livers can regenerate, albeit more slowly and less completely, as long as the extent of hepatectomy remains within safe functional limits. (HEPATOLOGY 1993;18:79–85).
Molecular Bases Of Early Neural Development In Xenopus Embryos
Authors: C Kintner
Journal: Annual Review of Neuroscience (1992)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
1946P Dysregulation of immune checkpoint proteins in newly- diagnosed early breast cancer patients
Authors: B.L. Rapoport, H.C. Steel, A.J. Theron, L. Heyman, F. Moosa, N. Hlatswayo, L.L. Kwofie, L. Jooste, C.A. Benn, S. Nayler, R. Anderson
Journal: Annals of Oncology (2020)
Haemochromatosis
Authors: A Pietrangelo
Journal: Gut (2003)

Iron is an important component of the Earth's crust, but its own chemistry greatly limits utilisation and also sets the basis for its toxicity. The capacity of readily exchanging electrons in aerobic conditions makes iron essential for fundamental cell functions, such as DNA synthesis, transport of oxygen and electrons, and cell respiration. On the other hand, as humans have no means to control iron excretion, excess iron, regardless of the route of entry, accumulates in parenchymal organs and threatens cell viability. In fact, a number of disease states (that is, iron overload diseases) attributable to genetic or acquired factors are pathogenetically linked to excess body iron stores and iron removal therapy is an effective lifesaving strategy in such circumstances.
Overview of Herbicide Mechanisms of Action
Authors: Stephen O. Duke
Journal: Environmental Health Perspectives (1990)

Commercial herbicides exhibit many different mechanisms of action. Several enzymes involved in biosynthesis of amino acids are sites of action for herbicides. A large number of different herbicide classes inhibit photosynthesis by binding to the quinone-binding protein, D-1, to prevent photosynthetic electron transfer. Several different types of herbicides apparently cause accumulation of photodynamic porphyrins by inhibiting protoporphyrinogen oxidase. Bipyridyliums and heteropentalenes cause the production of superoxide radicals by energy diversion from photosystem I of photosynthesis. Lipid synthesis is the site of action of a broad array of herbicides used in controlling monocot weeds. Herbicides of several classes apparently act by inhibiting mitosis through direct interaction with tubulin. Several other molecular sites of herbicide action are known. Despite a growing body of knowledge, the exact molecular sites of action of many herbicides are unknown. Some herbicides are known to have more than one site of action. Virtually all knowledge of herbicide structure-activity relationships is semiempirical. In addition to site of action structure-activity relationships, herbicide structure and chemical properties also strongly influence absorption, translocation, bioactivation, and environmental stability. Considering how little is known about all the potential sites of herbicide action, it is unlikely that during the next decade more than a relatively small number of site-specific herbicide structure-activity relationships will be developed.
CSIG-04. IMMUNE CHECKPOINT BLOCKADE AS A POTENTIAL THERAPEUTIC TARGET: SURVEYING CNS MALIGNANCIES
Authors: Amy Heimberger, Sarah Garber, Yuuri Hashimoto, Shiao-Pei Weathers, Joanne Xiu, Zoran Gatalica, Roel Verhaak, Shouhao Zhou, Gregory Fuller, Mustafa Khasraw, John de Groot, Sandeep Reddy, David Spetzler
Journal: Neuro-Oncology (2016)

Expression of PD-1/PD-L1 across glioma grades is undocumented and their interactions with commonly expressed genetic and epigenetic alterations undefined but nonetheless highly relevant to combinatorial treatments. Patients with CNS malignancies were profiled by Caris Life Sciences from 2009-2016. Immunohistochemistry (IHC) findings for PD-1 on tumor-infiltrating lymphocytes (TIL) and PD-L1 on tumor cells were available for 347 cases. Next generation sequencing, pyrosequencing, IHC, fragment analysis, and fluorescence in situ hybridization (FISH) were used to determine IDH1, PTEN, and TP53 mutational status, MGMT promoter methylation (MGMT-Me) status, PTEN expression, plus epidermal growth factor receptor variant III (EGFRvIII) and 1p19q codeletion status. PD-1+ TIL expression and grade IV gliomas were significantly positively correlated (OR 6.363, 95% CI 1.263, 96.236) - especially in gliosarcomas compared with GBM (p = 0.014). PD-L1 expression was significantly correlated with tumor grade with all PD-L1 positive cases (n=21) being associated with grade IV gliomas. PD-1+ TIL expression and PD-L1 expression were significantly correlated (OR 5.209, 95% CI 1.555, 20.144). Mutations of PTEN, TP53, BRAF, IDH1, and EGFR or MGMT-Me did not associate with increased intratumoral expression of either PD-1+ TIL or PD-L1 in GBM even before false discovery rate correction for multiple comparison. Targeting immune checkpoints in combination with other therapeutics based on positive biomarker selection will require screening of large patient cohorts.
The isolation of thyroxine (Edward C Kendall)
Authors: M. L. Nusynowitz
Journal: JAMA (1983)

How fitting that on Christmas day, 1914, while the armies of Europe were locked in mortal combat, there was isolated the substance that would be the salvation of unnumbered thousands afflicted with hypothyroidism, bringing to them life and well-being. On that day, Edward C. Kendall crystallized and isolated thyroxine, enabling the determination of its chemistry.<sup>1</sup>Within 12 years, Harrington and Barger<sup>2</sup>were able to delineate its structure and synthesize the hormone. Kendall's accomplishment was the capstone of more than 40 years of work on hypothyroidism. In 1871, Fagge<sup>3</sup>described spontaneous cretinism and speculated on the appearance of the disease occurring in adults, and three years later, Gull<sup>4</sup>first described adult myxedema. Although thyroid extirpation experiments in animals were occurring about this time, the association between Gull's disease and the thyroid gland was not well established until two Swiss surgeons, Reverdin and Kocher,<sup>5,6</sup>reported on the
Consensus pending on renal transplantation in children
Authors: E. R. Gonzalez
Journal: JAMA (1983)

Should young children with end-stage renal disease (ESRD) be treated with long-term hemodialysis, transplantation of a kidney from a cadaver donor, or a transplant from a living related donor (LRD)? Indeed, question some, given the uncertain outcome of all available treatments in terms of survival and quality of life, should these small patients be treated at all? The controversy continues, but mounting evidence seems to favor vigorous treatment.<i>Which</i>treatment promises a longer and better life for the afflicted child remains to be determined. In a poster session at the recent National Kidney Foundation meeting in Chicago, William E. Harmon, MD, assistant professor of pediatrics at Harvard Medical School, Boston, presented a comparative study of long-term dialysis, cadaveric transplantation, and LRD transplantation. The study encompassed 21 children treated at the Children's Hospital Medical Center, Boston, where Harmon is director of the dialysis unit. In a previous study of 120 children
Comparative effectiveness of bladder-preserving tri-modality therapy versus radical cystectomy for muscle-invasive bladder cancer.
Authors: Trevor Joseph Royce, Adam S. Feldman, Matthew Mossanen, Joanna C. Yang, William U. Shipley, Pari Pandharipande, Jason A. Efstathiou
Journal: Journal of Clinical Oncology (2018)

418 Background: Radical cystectomy (RC) has historically been considered the standard of care for muscle invasive bladder cancer (MIBC). An alternative is tri-modality therapy (TMT), a bladder-sparing approach that often achieves preservation of the native bladder. There are limited randomized data comparing these guideline-recommended approaches but, in appropriately selected patients, both are thought to have similar survival outcomes with different morbidity profiles. Therefore this study compared the effectiveness of TMT and RC using decision-analytic modeling with the primary endpoint of quality-adjusted life years (QALYs). Methods: We developed a Markov model simulating the lifetime outcomes for 67-year-old patients after definitive treatment for American Joint Committee on Cancer clinical Stage T2-T4aN0M0 MIBC using two strategies: TMT or RC +/- neoadjuvant chemotherapy (NAC). Probabilities and utilities were extracted from the literature to determine the incremental effectiveness in QALYs. Sensitivity analyses were performed. Results: TMT was the most effective strategy with an incremental gain of 1.13 QALYs over RC (8.37 versus 7.24 QALYs, respectively; Table). One-way sensitivity analyses demonstrated the model was most sensitive to the quality of life (QoL) parameters (i.e. the utilities) for RC and TMT; TMT was more effective than RC irrespective of the RC utility (the 95% confidence interval of the RC parameter demonstrated an incremental gain with TMT of 0.01 to 4.77 QALYs). The model was relatively less sensitive to the probability of death for either strategy. Probabilistic sensitivity analysis demonstrated that TMT was more effective than RC for 75% of model iterations. Conclusions: Treatment of MIBC with organ-sparing TMT in appropriately-selected patients may result in a gain of over 1 QALY relative to RC. Further prospective investigation into the QoL implications of these treatment modalities is warranted. [Table: see text]
Anesthesiology, Philadelphia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disseminated Trichosporon beigelii (cutaneum) infection in an artificial heart recipient
Authors: K. A. Murray-Leisure
Journal: JAMA (1986)

A 44-year-old man with end-stage ischemic cardiomyopathy was supported with an intra-aortic balloon and The Penn State Heart (artificial) prior to orthotopic cardiac transplantation on the 14th hospital day. At the time of transplantation, intraoperative cultures of pericardial and mediastinal fluid showed growth of<i>Trichosporon beigelii</i>(<i>cutaneum</i>). Shortly thereafter the patient developed visceral dissemination of<i>T beigelii</i>with no associated skin lesions. He was treated with amphotericin B and rifampin, but postmortem examination showed persistent, disseminated infection. (<i>JAMA</i>1986;256:2995-2998)
Members of the House of Delegates
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Edward Stevens, Gastric Physiologist, Physician and American Statesman.
Journal: Annals of Internal Medicine (1970)

Book Reviews sons and five daughters-five of whom survived.The youngest girl married a Dozent of Heidelberg, whilst the eldest married Johann Conrad Peyer-who described the 'patches' named after him.Wepfer was a popular man who was consulted from far and wide in Switzerland and Germany-as a map on page 37 shows.The medico-literary memoirs of the Wepfer family were bought by the Medical Faculty of Leyden in 1774 for one hundred and twenty gold ducats-six hundred guilders.The writings show Wepfer's interest in gastro-enterology of which he was an early pioneer.He was also concerned with toxicology, describing a case of ergotism in 1693, and with diseases of the chest.The book is enlivened by pleasing illustrations and a useful bibliography.It can be recommended to those interested in the early Swiss contributions to medicine.No. 28 in this series is a large paperback of ninety-nine pages and deals with the history of haemophilia from the Babylonian Talmud until 1965.After defining haemophilia the author gives an account of the geographical areas where the disorder has been described.In Switzerland it was first mentioned by Felix Platter in 1559.Problems of hereditary transmission are then considered with special reference to the Swiss family trees of von Tenna and von Wald, this latter having been traced back to about 1550.The various theories on the cause of the disorder are then discussed together with a more general account of the major discoveries in the physiology of the blood, naturally with specific reference to Swiss workers-Sahli, Fonio, Feissly, Lenggenhager and Koller.The final chapter concerns itself with questions on clinical matters and prophylaxis.This is a rather specialized monograph which will probably be of most interest to German-speaking haematologists.I. M. LIBRACH
Five years of experience with massive blood transfusions
Authors: R. F. Wilson
Journal: JAMA (1965)

In the five-year period, 1959-1963, 209 patients were given massive blood transfusions of at least 5,000 ml within a 24-hour period. The overall mortality was 45% and increased with the amount of blood given, the age of the patient, complicating medical conditions, and shock. When shock was prevented or quickly corrected, the mortality was 7%; however, when prolonged shock occurred in patients with preexisting or associated disease, the mortality was 93%. A serious bleeding diathesis occurred in seven patients. The incidence of wound complications in these patients was about four times that of the general surgical population for the hospital. One case of homologous serum jaundice occurred in a survivor.