tbuckley/cabot-search huggingface dataset:
Arzneikunde und Arzneiverordnung: Ein Lehrbuch
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Practical Handbook of Midwifery and Gynæcology for Students and Practitioners
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of a Ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy
Authors: Kung-Chia Young, Karen L. Lindsay, Ki-Jeong Lee, Wen-Chun Liu, Jian-Wen He, Susan L. Milstein, Michael M.C. Lai
Journal: Hepatology (2003)

Ribavirin (RBV), a guanosine analogue, has been suggested to exert an antiviral action against hepatitis C virus (HCV) by causing lethal mutations and suppressing RNA polymerase in vitro , but the mechanism of its clinical therapeutic effects is currently unknown. To test the hypothesis that RBV could act both as an RNA mutagen and inhibit viral RNA synthesis in vivo , we studied the evolution of the nucleotide sequences of HCV RNA at the nonstructural (NS) 5B region in patients receiving RBV, placebo, or interferon alfa (IFN–α) monotherapy. The RBV group showed a slightly more accelerated evolution rate of HCV RNA quasispecies than either the IFN–α or placebo group. RBV caused preferentially A–to–G and U–to–A mutations. Interestingly, an NS5B amino acid 415 Phe–to–Tyr (F415Y) mutation emerged in all (5 of 5) patients infected with HCV genotype 1a during the RBV treatment. Subsequently, the parental 415F strain reemerged in some patients after the treatment was discontinued. The effect of the amino acid substitution at NS5B415 on HCV RNA replication was then investigated using an HCV subgenomic replicon in Huh7 cells. We showed that treatment of replicon cells with RBV reduced the HCV RNA level of NS5B415F replicon, but not NS5B415Y, in a dose–dependent manner. Thus, NS5B F415Y mutation represents an RBV–resistant variant. The 3–dimensional modeling and structure analysis of NS5B protein revealed that the 415th amino acid is located at the P helix region of the thumb subdomain, which may interact with the minor groove of the template–primer duplex in the putative RNA–binding cleft. In conclusion, RBV could work as a weak mutagen for HCV RNA in HCV–infected patients. Furthermore, the selection of an RBV–resistant variant with a single amino acid substitution in NS5B suggested that RBV may directly interact with HCV RNA polymerase, thus interfering with its enzymatic activity. (Hepatology 2003;38:869-878).
Abstract 483: Targeting HDL Quality Rather than Quantity: Providing the Mechanistic Rationale for the Pharmacogenomic Interaction between the Haptoglobin Genotype and Vitamin E on Cardiovascular Disease in Individuals with Diabetes Mellitus
Authors: Rabea O Asleh, Shany Blum, Shiri Kalet-Litman, Michael Aviram, Andrew P Levy
Journal: Circulation (2008)

Objective. Pharmacogenomics is a key component of personalized medicine. ICARE, a prospective placebo controlled study, recently demonstrated vitamin E could dramatically reduce CVD in individuals with Diabetes Mellitus (DM) and the Haptoglobin (Hp) 2–2 genotype (40% of DM individuals). However, due to the large number of clinical trials which failed to demonstrate benefit from vitamin E coupled with the lack of a mechanistic explanation for why vitamin E should be beneficial only in DM individuals with the Hp 2–2 genotype, enthusiasm for this pharmacogenomic paradigm has been limited. In this study we sought to provide such a mechanistic explanation based on the hypothesis that the Hp 2–2 genotype and DM interact to promote HDL oxidative modification and dysfunction. Research Design and Methods. Clearance of 125 I-Hp 1 or 125 I-Hp 2-hemoglobin (Hb) complexes were assessed in non-DM and DM mice after injection of the complexes in the tail vein. Hb binding to HDL was assessed in HDL isolated by immunoprecipitation. Oxidative modification of HDL was assessed by measuring HDL associated lipid peroxides and redox active iron. HDL function was assessed based on its ability to promote cholesterol efflux from macrophages. A crossover placebo controlled study in Hp 2–2 DM humans and in Hp 1–1 and Hp 2–2 DM mice assessed the ability of vitamin E to reduce oxidative modification of HDL and improve HDL function. Results. In DM mice, the half-life of the Hp 2-Hb complex was dramatically increased. Immunoprecipitation studies demonstrated specific binding of Hp-Hb complex to HDL with over 25% of the injected Hp 2-Hb complex associating with HDL. Hb was found to be associated with HDL in all Hp 2–2 DM individuals and mice by western blot. Redox active iron and lipid peroxides associated with HDL were significantly increased and HDL function was remarkably impaired in Hp 2–2 DM individuals and mice. Vitamin E significantly decreased oxidative modification of HDL and improved HDL function in Hp 2–2 DM but had no effect in Hp 1–1 DM. Conclusions. In Hp 2–2 DM individuals, there is an increased amount of Hb bound to HDL which results in an oxidative modification of HDL and HDL dysfunction. Vitamin E significantly improves the quality of HDL and may explain the exclusive CVD benefit in this cohort.
Books Received
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cover Change
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Giant hernias managed by pneumoperitoneum
Authors: D. P. Connolly
Journal: JAMA (1969)

Pneumoperitoneum to reestablish abdominal space for the visceral contents of massive hernias has been little used in this country. Three patients were treated by this technique. The amounts of air injected were 7,000, 8,500, and 9,000 cc, respectively, in increments of 500 to 1,500 cc every other day. The development of flank tension was used as the cutoff point for each injection. Hernia repair was carried out after 10 to 14 days of treatment; the hernial defects varied in size from 6×6 cm to 10×14 cm. All defects were closed without the use of autogenous or foreign material mesh grafts. Complications included urinary retention, discoid atelectasis, and subcutaneous emphysema. The markedly stretched scrotal skin attenuates rapidly after hernia reduction, making plastic revision unnecessary. Pneumoperitoneum is easy to perform and nonhazardous, and should be used with greater frequency for adult patients with massive hernias.
Folic Acid Pitfall
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review The Diagnosis and Treatment of Postural Defects . By Winthrop Morgan Phelps, B.S., M.D., F.A.C.S., Professor of Orthopedic Surgery, Yale University, etc., and Robert J. H. Kiphuth, Assistant Professor of Physical Education, Yale University. Charles C. Thomas, Baltimore, Md., 1932. Price $4.00.
Journal: New England Journal of Medicine (1933)
Spontaneous colonic perforation. A complication in a hemodialysis patient
Authors: M. K. Ghose
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In This Issue
Journal: American Journal of Psychiatry (2005)

In This Issue Brains of Bipolar KidsCompared to adults with bipolar disorder, children and adolescents with this illness have more severe symptoms, a stronger genetic predisposition, and less past drug treatment.Their brains might therefore provide a clearer picture of anatomic abnormalities in bipolar disorder.Frazier et al. (p.1256) measured three brain regions in 43 youths with bipolar disorder and 20 healthy youths.The amygdala and thalamus showed no difference between groups, but the hippocampus, which provides context for learning and memory, was smaller in the bipolar youths.The bipolar girls showed an especially pronounced difference from the same-sex comparison subjects, and their mania scores were higher than those of the bipolar boys.The total cerebral volume in the bipolar group was also smaller than normal.Since total cerebral volume generally is normal in affected adults, bipolar disorder in children and adolescents may follow a different neurodevelopmental path.
Influence of Brain Catecholamine upon the Gastric Secretion
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent changes in attack and survival rates of acute myocardial infarction (1975 through 1981). The Worcester Heart Attack Study
Authors: R. J. Goldberg
Journal: JAMA (1986)

A communitywide study was conducted in all 16 acute general hospitals in the metropolitan Worcester, Mass, area during the calendar years 1975, 1978, and 1981 to examine time trends in the attack and case-fatality rates of patients hospitalized with validated acute myocardial infarction as well as of the occurrence of out-of-hospital coronary heart disease (CHD) deaths. Between 1975 and 1981, there was an increase in the age-adjusted attack rates of initial events of acute myocardial infarction (1975, 254/100,000; 1981, 280/100,000) as well as recurrent events (1975, 133/100,000; 1981, 156/100,000). These overall increases were due to an increase among those 65 years of age and older, with no significant changes observed in those less than 65 years old. The age-adjusted in-hospital case-fatality rates declined from 22.1% in 1975 to 20.3% in 1978 and 17.4% in 1981. In examining long-term prognosis, no significant differences were seen over an eight-year follow-up period between patients discharged in 1975, 1978, and 1981. The age-adjusted mortality rates of out-of-hospital CHD deaths significantly declined between 1975 (229/100,000) and 1981 (147/100,000). The results of this population-based survey suggest that recently observed declines in the mortality rates of CHD may reflect decreases in out-of-hospital coronary deaths and improving trends in the in-hospital survival of patients with acute myocardial infarction. (<i>JAMA</i>1986;255:2774-2779)
Benjamin Franklin
Authors: Jonathon Erlen
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROTECTIVE DEVICES FOR THE HEART
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reaching the top.
Journal: BMJ (1970)

M fCOLreaction from occurring?It should first be recognized that some women are at greater risk than others and that they include those who have had previous attacks of depression, those with progestogenic menstrual cycles, and those who normally suffer from premenstrual depression.Even despite the conclusions of Dr. Herzberg and her colleagues it may be wise to prescribe a weakly progestogenic or sequential oral contraceptive5 and if more than one of these findings is present to advise some other method of contraception.Secondly, an assessment of mood should be part of the routine examination of all women taking oral contraceptives.Symptoms of depression should be looked for, as they may not be volun- teered, and if necessary the doctor should advise changing or even abandoning the oral contraceptive.
Cranioplasty
Authors: Axel K. Olsen
Journal: JAMA (1963)

<h3>To the Editor:</h3> —In the Questions and Answers section of the June 15 issue ofThe Journal(<b>184</b>:909, 1963) a physician inquired regarding cranioplasty for a 5½-year-old boy with a defect measuring 1% sq in. A defect of this size, in my experience, would be covered by solid bone within a matter of a year or 18 months. Secondly, if the dura is intact, even though the bone defect does not close over completely in large defects, there will be, in my opinion, no significant protrusion of the brain into the defect, and, therefore, no abnormalities (eg, progressive atrophy) will be produced in the cortex. Thirdly, I think it is generally accepted that even moderate-sized defects in children's skulls do not need plastic repair, since the growth process in children's skulls is quite adequate. Lastly, the answer supplied by the consultant seems to me to be quite vague from
Medical care and public health in California
Authors: L. Breslow
Journal: JAMA (1966)

Public health, based on the science of epidemiology, is concerned with all of the factors that influence the occurrence and outcome of disease. Medical care, with recent advances in medical science, has become one of the important factors in determining the outcome of disease. Although the great debate on medical care focused on the economic aspects of the problem, the popular interest was probably motivated by recognition that medical care can now save many lives and avoid or minimize much disability. The health potential of medical care, rather than its cost, probably underlies the tremendous concern of the American people for obtaining it. Amounts and methods of payment, and how and by whom the money shall be raised, have been obstacles to achieving something good for health. Unfortunately, the obstacle, rather than the goal, has attracted the principal attention. Now that the major decisions on payment have been made, the