tbuckley/cabot-search huggingface dataset:
Abstract 833: MicroRNA-206 Controls Cardiac Myosin Heavy Chain Gene Expression By Targeting RXR-α
Authors: Hitoo Nishi, Koh Ono, Yoshitaka Iwanaga, Takahiro Horie, Minako Kinoshita, Kazuya Nagao, Rieko Mori, Koji Hasegawa, Toru Kita
Journal: Circulation (2007)

MicroRNA (miRNA) is a small noncoding RNA that modulates posttranscriptional translation. Growing evidence indicates that miRNA is involved in basic cell functions and oncogenesis. In order to find a possible functional role of miRNA in the heart, we first suppressed the expression of Dicer and Ago2, which are required for miRNA biogenesis and function, by lenti-virus-mediated siRNA in neonatal rat cardiomyocytes. Knockdown of Dicer and Ago2 expression significantly increased their beating rate; therefore, we hypothesized that miRNA may regulate the expression of cardiomyocyte contractile protein since cardiac contractility depends on the expression of two myosin heavy chain (MHC) genes, α and β, which are regulated in an antithetical manner by developmental, physiological, and pathological signals. As siRNA against Dicer, which results in the loss of all miRNA function, upregulated α-MHC and downregulated β-MHC mRNA expression, we tried to identify functional miRNAs which have an opposite effect against Dicer siRNA on α/β-MHC expression in the heart. We first performed miRNA microarray analysis in the heart of Dahl salt-sensitive rats in which systemic hypertension caused compensated concentric left ventricular hypertrophy (LVH) at the age of 11 weeks, followed by congestive heart failure (CHF) at the age of 17 weeks. In this model, decreased α/β-MHC ratio is observed at LVH and CHF stages. Next we overexpressed miRNAs which are upregulated in LVH and CHF stages in neonatal rat cardiomyocytes by lenti-virus. After screening these miRNAs, miR-206 was found to decrease the α/β-MHC mRNA expression ratio. The computational miRNA target prediction algorithm showed one of the targets of miR-206 is RXR-α, which regulates α/β-MHC transcription. Forced expression of miR-206 reduced the translation of RXR-α. Moreover, when the expression of RXR-α was downregulated by siRNA, the α/β-MHC mRNA expression ratio decreased in the same manner as miR-206. In conclusion, miR-206 controls the gene expression of MHC isoforms by targeting RXR-α, and these results suggest that miR-206 regulates cardiac contractility.
American Journal of Diseases of Children, Chicago
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effects of N -acetylcysteine and anti-intercellular adhesion molecule-1 monoclonal antibody against ischemia-reperfusion injury of the rat steatotic liver produced by a choline-methionine-deficient diet
Authors: H Nakano, H Nagasaki, A Barama, K Boudjema, D Jaeck, K Kumada, M Tatsuno, Y Baek, N Kitamura, T Suzuki, M Yamaguchi
Journal: Hepatology (1997)

Abundant fat in the liver has been implicated in poor outcome after liver transplantation or liver surgery, but the reasons for this association are still unclear. The aim of the present study was to examine mechanisms that may be involved in hepatic dysfunction after ischemia-reperfusion (I/R) of the steatotic rat liver. Steatosis was produced by a choline-methionine-deficient (CMDD) diet. In the first experiment, isolated perfused rat livers, subjected to 24-hour cold storage followed by 120-minute reperfusion, were used to investigate hypothermic I/R injury of the steatotic rat liver. In the second experiment, livers were subjected to 60-minute partial left lobar vascular clamping to allow study of normothermic I/R injury. In the first experiment, compared with normal nonsteatotic liver, steatotic livers showed significantly greater injury, as assessed by amounts of hepatic enzymes released into the perfusate, bile production, the concentrations of reduced glutathione (GSH) in the perfusate, as well as in the livers themselves, and electron microscopic findings of sinusoidal microcirculatory injury. The addition of N -acetylcysteine (NAC), a precursor of glutathione, to the liver before cold storage significantly improved these parameters in steatotic livers. The second experiment showed that, compared with nonsteatotic livers, steatotic livers had lower concentrations of GSH and impaired rates of bile production. There was also evidence of increased oxidative stress in polymorphonuclear leukocytes (PMNLs) in liver or peripheral blood of rats with fatty livers. An anti-rat intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody inhibited neutrophil infiltration into pericentral sinusoids and improved these parameters in the steatotic rats. We conclude that sinusoidal microcirculatory injury is involved in hypothermic I/R injury, that oxidative stress produced by PMNLs is involved in normothermic I/R injury, and that NAC and anti-rat ICAM-1 monoclonal antibody restore liver integrity in I/R injury.
The head-start project Georgia: a three-armed, cluster, non-randomised trial of the effectiveness of two novel models of HCV confirmatory testing in harm reduction sites (HRS) in Georgia
Authors: Maia Japaridze, Jessica Markby, Irma Khonelidze, Maia Butsashvili, Maia Alkhazashvili, Sonjelle Shilton
Journal: Journal of Hepatology (2020)
Lectures on the Comparative Anatomy and Physiology of the Vertebrate Animals. Delivered at the Royal College of Surgeons, of England, in 1844 and 1846
Journal: BMJ (1847)

Orrnions oF VoLUME THE SixrH."The period upon which the latest historian of Imperial Rome has entered in his sixth volume, possesses peeuliar interest at present, from the variety and vividness of the details no less than its pregnant facts and ominous analogies.eee To English readers the opening scene of the History is specially attractive, setting forth the second great invasion of Britain.......The story as told by Mr. Merivale gives us, in picturesque and vivid chapters, details of the history
Notice
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Aging on Alveolar Pores of Kohn in the Dog
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Embryonal carcinoma. An unexpected cause of sudden death in a young adult
Authors: R. S. Aronsohn
Journal: JAMA (1974)

SUDDEN death occurring in young adults is rare. Luke and Helpern<sup>1</sup>reviewed 275 consecutive cases of sudden death in patients between the ages of 28 and 44 years and found that of these deaths, 38% were caused by coronary arterial atherosclerosis, 26% by fulminant untreated infectious diseases, and 4% by pulmonary arterial emboli. Seven of the 11 patients who died of pulmonary arterial emboli were women. Pelvic veins contained thrombi in two of 11 patients, and thrombi were found in the veins of the lower extremities in the remaining nine. This communication reports an unusual case of sudden death caused by pulmonary arterial emboli in a young man. <h3>Report of a Case</h3> A 21-year-old white man was perfectly well until, while at work and having had just returned from a coffee break, he fell to the floor. He was found without a palpable pulse or detectable respiratory movement. Resuscitation
Exercise Rehabilitation for Treatment of Claudication-Reply
Authors: Andrew W. Gardner
Journal: JAMA (1996)

<h3>In Reply.</h3> —We fully agree with the statement by Dr Hirsch and colleagues that exercise performance is not solely dependent on large artery blood flow and that intermittent claudication can be improved without revascularization. Our meta-analysis, along with the additional articles cited by Hirsch and colleagues, supports the notion that exercise rehabilitation is an effective treatment for patients with peripheral arterial occlusive disease and disabling claudication pain. Hirsch and colleagues raise another key point concerning the availability of vascular rehabilitation programs in health care facilities. Patients with intermittent claudication frequently have concomitant atherosclerosis in the coronary and cerebrovascular arteries, as well as a host of other comorbidities. Consequently, the risks associated with exercise in patients with claudication are similar to those of patients with cardiac disease, emphasizing the need for a closely supervised program that can only be accomplished in a health care facility. An additional benefit of a supervised
Chromosomal Methods in Population Studies
Authors: Mary K. Conner, Niel Wald
Journal: Environmental Health Perspectives (1981)

A brief description of chromosome aberrations and sister chromatid exchange (SCE) as cytogenetic endpoints for evaluation of DNA damaging agents is presented. Problems associated with the use of cytogenetic assays as population monitors of radiation and chemical exposures are discussed. Adequate cell sample size requirements and accurate assessment of cummulative exposure effects with increasing age are stressed as important considerations for reliable cost-benefit analysis of population studies involving low level exposures. Examples of population studies using SCE as an indicator of specific chemical exposures are cited, and factors contributing to variations in control baseline SCE levels are discussed. Possible implications of population cytogenetic data on general public health are suggested.
Monitoring Behavioral Risk Factors for Cardiovascular Disease in Russia
Authors: Thomas L Schmid
Journal: Circulation (2001)

0008 The purpose of the project was to provide assistance to Russia in establishing a national surveillance system for monitoring CVD risk factors. The Behavioral Risk Factor Surveillance System, which was developed in the US and is used by all State Health Departments, served as a template for the Russian system. Personal interviews, mail-based and telephone-based surveys were reviewed and considered. Questions were taken from previous Russian, European, and US surveys to collect information on smoking, alcohol use, fruit and vegetable consumption, physical activity, blood pressure, self-reported CVD symptoms and previously diagnosed diseases. This was the first Russian phone-based health survey and was piloted in Moscow where a random sample of 6065 was selected from the 2,560,633 private phone listings. Initial analysis found that in general, prevalence of CVD risk factors was higher than in similar American surveys. The current smoking rate reached 52%, 30% had a BMI below 24 kg/m 2 , 60% reported average daily fruit consumption of less then 1/4 of a pound (200 g) per person in the summer, elevated, untreated blood pressure (more then 140/90 mm Hg) was reported by 25 % while another 10 % received medication for hypertension, 18% of men and 4% of women reported heavy drinking. Though duration of walking was rather high compared with the US (about 90 min per day), only 5 % engaged in other moderate physical activity on a regular basis; 20% of respondents said that they experienced CVD symptoms or were diagnosed with CVD. In general, CVD risk factors were more prevalent among men. Next year 11 additional sites will conduct the survey. These data help fill the gap in public health knowledge related to prevalence of CVD risk factors in Russia and demonstrate the value of establishing a monitoring system. They also indicate that immediate preventive measures are needed to improve the health status of the population.
Quebec's Medical Mystery Spreads
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advances in acute lymphoblastic leukemia genomics
Authors: Christine J. Harrison, Claire Schwab
Journal: HemaSphere (2018)

Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Spicy Remedy?
Authors: Joan Stephenson
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Controlled Trial to Improve Care for Seriously III Hospitalized Patients
Authors: Alfred F. Connors
Journal: JAMA (1995)

<h3>Objectives.</h3> —To improve end-of-life decision making and reduce the frequency of a mechanically supported, painful, and prolonged process of dying. <h3>Design.</h3> —A 2-year prospective observational study (phase I) with 4301 patients followed by a 2-year controlled clinical trial (phase II) with 4804 patients and their physicians randomized by specialty group to the intervention group (n=2652) or control group (n=2152). <h3>Setting.</h3> —Five teaching hospitals in the United States. <h3>Patients.</h3> —A total of 9105 adults hospitalized with one or more of nine life-threatening diagnoses; an overall 6-month mortality rate of 47%. <h3>Intervention.</h3> —Physicians in the intervention group received estimates of the likelihood of 6-month survival for every day up to 6 months, outcomes of cardiopulmonary resuscitation (CPR), and functional disability at 2 months. A specially trained nurse had multiple contacts with the patient, family, physician, and hospital staff to elicit preferences, improve understanding of outcomes, encourage attention to pain control, and facilitate advance care planning and patient-physician communication. <h3>Results.</h3> —The phase I observation documented shortcomings in communication, frequency of aggressive treatment, and the characteristics of hospital death: only 47% of physicians knew when their patients preferred to avoid CPR; 46% of do-not-resuscitate (DNR) orders were written within 2 days of death; 38% of patients who died spent at least 10 days in an intensive care unit (ICU); and for 50% of conscious patients who died in the hospital, family members reported moderate to severe pain at least half the time. During the phase II intervention, patients experienced no improvement in patient-physician communication (eg, 37% of control patients and 40% of intervention patients discussed CPR preferences) or in the five targeted outcomes, ie, incidence or timing of written DNR orders (adjusted ratio, 1.02; 95% confidence interval [Cl], 0.90 to 1.15), physicians' knowledge of their patients'preferences not to be resuscitated (adjusted ratio, 1.22; 95% Cl, 0.99 to 1.49), number of days spent in an ICU, receiving mechanical ventilation, or comatose before death (adjusted ratio, 0.97; 95% Cl, 0.87 to 1.07), or level of reported pain (adjusted ratio, 1.15; 95% Cl, 1.00 to 1.33). The intervention also did not reduce use of hospital resources (adjusted ratio, 1.05; 95% Cl, 0.99 to 1.12). <h3>Conclusions.</h3> —The phase I observation of SUPPORT confirmed substantial shortcomings in care for seriously ill hospitalized adults. The phase II intervention failed to improve care or patient outcomes. Enhancing opportunities for more patient-physician communication, although advocated as the major method for improving patient outcomes, may be inadequate to change established practices. To improve the experience of seriously ill and dying patients, greater individual and societal commitment and more proactive and forceful measures may be needed. (<i>JAMA</i>. 1995;274:1591-1598)
P121 (0089) SEQUENTIAL TIME‐INTENSIFIED BRENTUXIMAB VEDOTIN (BV) FOLLOWED BY GEMCITABINE, VINORELBINE AND PEGYLATED LIPOSOMAL DOXORUBICINE (GVD) AS A BRIDGE TO AUTOLOGOUS TRANSPLANTATION IN DHAP RESISTANT RELAPSED OR REFRACTORY CD30+ LYMPHOMA
Journal: HemaSphere (2018)
Psychosurgery
Authors: Peter R. Breggin
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The Journal(225:916, 1973) described me as "Undoubtedly the one person most responsible for politicizing psychosurgery...." In this and a succeeding article (225:1035, 1973), the writer defends lobotomists and psychosurgeons and promotes their work as pure science unhappily corrupted by political attacks. Nothing could be further from the truth. The psychosurgeons offer no more scientific evidence than they did in the first disastrous wave of lobotomies and as early as 1967 attempted to gain public and congressional support for their work by linking it to political fears of violent ghetto uprisings and assassinations. I only entered the political arena as a counterforce to their own strenuous political campaign. Drs. Mark, Sweet, Ervin, and Delgado were featured (1968) in a cover story in<i>Life</i>.<sup>1</sup>On the cover are pictures of Sirhan Sirhan and Earl Ray with the headlines, "The Two Accused," and "The Psychobiology of Violence." The article
European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE) 2011 – call for abstracts
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2011)

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Life and Letters of Mary Putnam Jacobi.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal