tbuckley/cabot-search huggingface dataset:
Trends in surgical revascularization for renal artery disease. Ten years' experience
Authors: A. C. Novick
Journal: JAMA (1987)

We reviewed our experience with surgical revascularization (SR) for renal artery disease (RAD) in 361 patients from 1975 through 1984 to illustrate the evolving role of SR in the management of these patients. The time intervals selected for comparison were 1975 through 1980 (n=174) and 1981 through 1984 (n=187). Since 1981, in patients with atherosclerosis, SR has been done more often in elderly patients (30% vs 10.4%), in patients with generalized atherosclerosis (87% vs 73%), and for the sole purpose of preserving renal function (36% vs 14%). Since 1981, fewer patients with atherosclerosis have undergone SR solely to treat renovascular hypertension (26% vs 41%). Since 1981, in patients with fibrous dysplasia, SR has been done in more patients with branch renal artery disease (70% vs 28%). These trends in the performance of SR have been due to the advent of percutaneous transluminal angioplasty as effective therapy for certain patients, improved results of SR in elderly patients with atherosclerosis, an enhanced appreciation of advanced atherosclerotic RAD as a correctable cause of renal failure, and the development of more effective techniques for SR in patients with severe aortic atherosclerosis and branch RAD. The overall clinical results of SR remain excellent in properly selected patients with RAD. (<i>JAMA</i>1987;257:498-501)
Erratum to: De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial
Authors: Marc Leone, Carole Bechis, Karine Baumstarck, Jean-Yves Lefrant, Jacques Albanèse, Samir Jaber, Alain Lepape, Jean-Michel Constantin, Laurent Papazian, Nicolas Bruder, Bernard Allaouchiche, Karine Bézulier, François Antonini, Julien Textoris, Claude Martin
Journal: Intensive Care Medicine (2014)
Medical Journal of Australia, Sydney
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Croonian Lectures on Some Points in the Pathology and Treatment of Typhoid Fever
Authors: W. Cayley
Journal: BMJ (1880)

concerned in specialised, co-ordinated movements, in emotions, and also in intellectual processes.The fact that some patients in these attacks fall suddenly, and remain still for a few moments before the co-ordinated movements commence, has been regarded by Dr. Hughlings Jackson (adopting a theory of the late Dr. Dickson) as evidence that the "co-ordinated" phenomena are always due to the release of lower centres from the control of the higher by the temporary discharge of the latter.He has urged that an actual discharge of grey matter can only give rise to inco-ordinate "brutal" effects.That co-ordinated
Abstract 1263: Targeting of CDCA8 suppresses hepatocellular carcinoma growth by restoring ATF3 tumor suppressor and inactivating oncogenic Akt signaling
Authors: Keon Uk Park, Min Ji Ko, Ilseon Hwang, Hun-Mo Ryoo, Yun-Han Lee
Journal: Cancer Research (2019)

Abstract Background: Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide which remains a major challenge due to poor prognosis and limited treatment options. Cell division cycle associated 8 (CDCA8) is known as a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle and it is commonly overexpressed in human HCC. However, the functional role of CDCA8 in HCC progression remains to be clarified. In this study, we hypothesized if targeting of CDCA8 with small interfering (si) RNA could alter the course of HCC progression. We also investigated the molecular mechanism that mediates HCC cell death caused by CDCA8 silencing. Methods: Human HCC cell lines, Huh1 and Huh7, were transfected with CDCA8 siRNA and tested for growth inhibition and apoptotic induction using MTS, FACS and Western blotting. To obtain insights into the molecular changes in response to CDCA8 knockdown, global changes in gene expression were examined using RNA sequencing. Results: siRNA silencing of CDCA8 inhibited HCC cell growth and long-term colony formation by blocking cell cycle progression and by inducing apoptotic cell death. RNA sequencing data showed that, representatively, the anti-proliferative effects were driven by a subset of molecular alterations including the upregulation of tumor suppressive ATF3 and GADD34 genes and the downregulation of BGLAP, a key regulator of cell growth and invasiveness. Subsequent Western blot analysis affirmed that CDCA8 silencing induces the increase in the levels of ATF3 and GADD34 and the decrease in phosphorylated Akt in both Huh1 and Huh7 cells. Also, the same condition decreased the levels of PARP-1 and pro-caspase 3, accelerating apoptosis. Of importance, silencing of CDCA8 expression effectively suppressed HCC tumor growth in a murine xenograft model. Conclusion: These findings suggest that targeting CDCA8 could be an attractive option for molecular therapy of HCC. Citation Format: Keon Uk Park, Min Ji Ko, Ilseon Hwang, Hun-Mo Ryoo, Yun-Han Lee. Targeting of CDCA8 suppresses hepatocellular carcinoma growth by restoring ATF3 tumor suppressor and inactivating oncogenic Akt signaling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1263.
MISCELLANEA MEDICA
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatric Diagnosis
Authors: George Winokur
Journal: JAMA (1974)

The authors of this book have for a long time been important members of an Arthurian Round Table from which many research forays into the field of psychiatry have emanated. The Holy Grail in this case is a scientific psychiatry. Though many members of this department involved themselves in biological research, the orientation was neither organic nor psychological; rather, it is best defined as data oriented. The emphasis was on the gleaning of valid evidence that could be related to precise psychiatric diagnosis. The goal was the elucidation of specific and relatively homogeneous disease entities. This book, then, is an effort to describe various aspects of psychiatric illnesses in a data-bound fashion. Unlike the American Psychiatric Association Manual, which is based on best clinical judgment and experience, the present volume documents its statements with reference to clinical research. Thus, few statements in the book are made that cannot be supported
Risk Factors for Donor-Type Aplasia After Bone Marrow Transplant in Children with Acquired Bone Marrow Failure Syndrome
Authors: Asahito Hama, Yoshiyuki Takahashi, Nao Yoshida, Masafumi Ito, Atsushi Narita, Hirotoshi Sakaguchi, Sayoko Doisaki, Hideki Muramatsu, Koji Nakanishi, Kimikazu Matsumoto, Koji Kato, Seiji Kojima
Journal: Blood (2012)
Addiction Medicine Specialists Add a New Therapeutic Approach
Authors: S. Lurie
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rubella Vaccination
Authors: Stanley A. Plotkin
Journal: JAMA (1971)

An experiment of colossal proportions is now going on with respect to rubella vaccination in the United States, albeit without calling it such. The experiment seeks to determine whether mass vaccination of children will prevent the spread of wild rubella virus through them to their mothers. The known facts in support of this policy are that the vaccine strains produce antibodies that prevent the vaccinee from developing clinical rubella, and that children form the largest epidemiologic reservoir of natural rubella. The concept of "herd immunity" has been invoked in the argument that immunization of a large proportion of children will interrupt the circulation of wild virus. Unfortunately, like true love in La Rochefoucauld's famous aphorism, everybody has heard of herd immunity in rubella, but no one has seen it. Studies of children and military recruits have shown high rates of reinfection in vaccinees and undiminished infection in seronegative contacts, although
CUTTING-EDGE EFFECTIVE ENDOSCOPIC TECHNIQUE TO REMOVE SCARRED POLYPS
Authors: B Mangiavillano, G Pellegatta, R Maselli, PA Galtieri, P Bhandari, DA Ferdinando, M Badalamenti, A Fugazza, A Anderloni, EC Ferrara, S Carrara, M Di Leo, A Repici
Journal: Endoscopy (2020)

We report the case of a 80-year-old female with a scarred polyp in the rectum previously treated by multiple endoscopic mucosal resection (EMR) and APC. Surveillance colonoscopy showed, three centimeters above the anal verge, a LST-G of 40 mm, hemicirconferential with adenomatous pit pattern (Kudo IIIL). After circumferential mark with APC and submucosal injection, by using EndoRotor, complete resection was achieved. PuraStat was applied over the resection base. The patient was discharged the same day. The resected tissue fragments were collected and histological assessment showed a tubule-villous adenoma with low-grade dysplasia. No recurrence was endoscopically revealed at 6 months’ follow-up.
PROTEIN HYPERSENSITIVENESS AND ITS IMPORTANCE IN THE ETIOLOGY OF DISEASE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improvement of depression and triggering of mania by sleep deprivation
Authors: T. A. Wehr
Journal: JAMA (1992)

<h3>SELECTED CASES</h3><h3>CASE 1.</h3> —William Styron, author of several novels, including<i>Lie Down in Darkness, The Confessions of Nat Turner</i>, and<i>Sophie's Choice</i>, became clinically depressed in 1985 at the age of 60 years. In his book,<i>Darkness Visible</i>(the title of which was taken from Milton's description of hell in<i>Paradise Lost</i>), he provides an extraordinary account of the symptoms and course of his illness. I have chosen to include a few of his observations herein because they seem to illustrate important connections between depression, sleep, and a classic symptom of depression—diurnal variation in mood. Styron's depression began when he stopped drinking alcohol. Gradually, he developed anhedonia and feelings of worthlessness and had thoughts of death. Ultimately: "The act of writing itself, becoming more and more difficult and exhausting, stalled, then finally ceased. "<sup>1(p46)</sup>As is typical in depression, the severity of Styron's symptoms had a striking daily rhythm:
LUPULON, AN ANTIBIOTIC FROM HOPS
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac Myocyte Gq Signaling Decreases Cardiac Function During Chronic High Blood Pressure Through Cardiac Remodeling
Authors: David M Harris
Journal: Circulation (2007)

Abstract 290 David M Harris, Thomas Jefferson University, Philadelphia, PA; Xiongwen Chen, Temple University, Philadelphia, PA; Stephanie Pesant, Heather I Cohn, Thomas Jefferson University, Philadelphia, PA; Scott M MacDonnell, Temple University, Philadelphia, PA; Mattieu Boucher, Korin Faulkner, Maggie Shapiro, Patrick Most, Thomas Jefferson University, Philadelphia, PA; Steven R Houser, Temple University, Philadelphia, PA; Walter J Koch, Andrea D Eckhart, Thomas Jefferson University, Philadelphia, PA David M Harris, 2007 Finalist and Presenting Author
Down's Syndrome and Maternal Age in British Columbia, 1972-75
Authors: A. J. F. Griffiths, R. B. Lowry, D. H. G. Renwick
Journal: Environmental Health Perspectives (1979)

The occurrence of Down's syndrome in British Columbia during the period 1972-75 is analyzed with respect to maternal age distribution.This period is compared with previously studied periods.No marked trends are evident in the various age group-specific rates studied.The significance of these findings is discussed in connection with a possible role of environmental mutagens in induction of Down's syndrome and the maternal age effect.
Mental Illness
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acupuncture
Authors: Teruo Matsumoto
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Some questions have been raised as to the effectiveness of acupuncture therapy in the hands of a non-Oriental American physician vs those of an Oriental physician. A unique test for this question has occurred at the Division of Surgical Research at Hahnemann Medical College and Hospital, Philadelphia. An Oriental-born but American-trained, Board-certified general surgeon, I trained my research fellow, Dr. Bruce Levy, who was resident in anesthesiology, in the art of acupuncture. The technique for acupuncture therapy for each disorder was the same used by each of these two physicians because of the preceptorship type of training. In more than 200 patients treated with intractable pain from osteoarthritis of the cervical or lumbosacral spines and in more than 40 patients with proven refractory migraine headaches, the results of acupuncture therapy were similar no matter which physician performed the treatment. In the 100 patients with osteoarthritis whom Dr.
Prophylactic Antibiotics
Authors: William A. Miller
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Dr Scheckler is to be commended for his recent EDITORIAL (1983;248:1328) in which he stresses the importance of "both scientifically rational and cost-effective data on which to base decisions about surgical antimicrobial prophylaxis." I would like to go a step further and suggest more forethought before using any prophylactic antibiotics. Although infections are common to all specialties, each has its specific problems and concerns. I specialize in orthopedics and can address the status of prophylactic antibiotics specifically. Postoperative wound infections in orthopedic surgery vary from the inconsequential to the disastrous. Failure to categorize this difference has led to much confusion in the literature. Fogelberg and associates<sup>1</sup>inadvertently imply this when they state that the rate of postoperative infections requiring surgical drainage was not significantly different in their antibiotic-treated and control group. The data in a frequently quoted article by Boyd and co-workers<sup>2</sup>actually show no statistically
Photosensitivity Dermatitis: Cause and Treatment
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuale Delle Malattie dell 'Occhio Ad Uso Degli Studenti E Dei Medicin Pratici Traduzione Italiana Sulla Quarta Edizione Americana.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal