tbuckley/cabot-search huggingface dataset:
Hematologic data of healthy very old people
Authors: N. P. Zauber
Journal: JAMA (1987)

Hematologic values were analyzed for 44 people who were 84 years of age or older. Individuals were selected based on extensive long-term records confirming their excellent health. Mean hemoglobin values were 14.8 ±1.1 g/dL (148 ± 11 g/L) for men and 13.6 ± 1.0 g/dL (136 ± 10 g/L) for women. Mean values were also computed for red blood cell indexes, red and white blood cell counts, sedimentation rate, and serum iron, and all values were compared with those of a concurrent control group of healthy young adults. Results are discussed in the context of previous reports on hematologic data of the elderly. (<i>JAMA</i>1987;257:2181-2184)
Diabetes Mellitus
Authors: Samuel B. Beaser
Journal: New England Journal of Medicine (1954)

IN this report, the following aspects of diabetes mellitus are considered: biochemistry and physiology; pathology and pathogenesis; diagnosis; associated conditions; treatment; pregnancy and diabetes; and complications.Carbohydrate MetabolismThe experimental use of C14-labeled molecules continues to expand knowledge of the role of insulin in accelerating carbohydrate metabolism. In general the acceleration takes place at two widely divergent points: at the introduction of glucose into the glycolytic cycle and at the entrance to the tricarboxylic acid cycle. The latter is the junction of reactions in equilibrium with protein and fat metabolism on the one hand and oxidation to carbon dioxide . . .
Heavy smokers, smoking cessation, and clonidine. Results of a double-blind, randomized trial
Authors: A. H. Glassman
Journal: JAMA (1988)

Seventy-one heavy smokers who had failed in previous attempts to stop smoking participated in a randomized clinical trial to test the efficacy of clonidine as an aid in smoking cessation. The success rate in clonidine-treated subjects (verified by serum cotinine concentration) was more than twice that in the placebo-treated subjects. When the data were stratified by gender, a strong effect present in women was not apparent in men. After six months, cessation rates remained significantly higher among smokers treated with clonidine than those receiving placebo. The data also revealed an unexpectedly high prevalence (61%) of a history of major depression in this sample and a significant negative effect of such a history on cessation regardless of treatment. These findings, highly suggestive of an important role of clonidine in smoking cessation, warrant further studies to establish the long-term (≥12 months) efficacy of this drug and to replicate the association between nicotine dependence and depression. (<i>JAMA</i>1988;259:2863-2866)
Who speaks for the patient?
Authors: C. D. Aring
Journal: JAMA (1966)

The tendency to substitute the laboratory for the classical method of diagnosis is the despair of humanistic teachers. The trend to the laboratory as an alternative to "learning" the patient is seen in the novice, the harassed, the disorganized, and the lazy. The laboratory has become widely known as a tool of science and those who do not consider the matter too deeply are in danger of becoming enamored of it as a routine in the care of sick people. Since the laboratory is synonymous with research, and research has become the order of the day, inductive clinical analysis may be deprecated as a subjective method and, therefore, of lesser order. The largesse that has become available to academic medicine in the United States since the last world war does nothing to improve the situation. To derive these funds requires that research be processed with the result that some perfectly
METHOD OF DETERMINING APPROXIMATE TIME OF DEATH
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergy and Immunity in Ophthalmology.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Saccharin and bladder cancer
Authors: Irving I. Kessler, J. Page Clark
Journal: JAMA (1979)

In the concluding paragraphs of our article, we sought to explain the divergent findings of our study and those of Howe et al (<i>Lancet</i>2:578-581, 1977) on the basis of methodological distinctions. We pointed out that the Canadian investigators "apparently queried their patients on the use of tablet or drop sweeteners but not on powders." Dr Miller and his colleagues appear to concede this point in stating that "the use of powders is not specifically mentioned in the probing sentence on the questionnaire." They do not challenge our statement that "their interview omitted the ascertainment of calendar period in which sweeteners were used; thus, the analysis may have included subjects who used saccharin<i>after</i>the onset of cancer." Nor do they question our judgment that "their 'ever-or-never' analysis of saccharin use is subject to bias if patients and controls differed in the proportions reporting single, one-time, or occasional
The two-compartment circulatory model used for enzymatic infarct quantitation.
Authors: M P Visser
Journal: Circulation Research (1978)

Angiotensin Metabolism and Control of Renin ReleaseBailie and Oparil 1 have found that reduction of renal blood flow results in increased catabolism of angiotensin II.They suggest that this results in less angiotensin II being available to inhibit renin secretion, thus explaining why renin release is increased with reduced renal perfusion.However, renin release may also be increased by ureteral constriction 2 which does not significantly affect angiotensin II metabolism.'A mechanism which removes this discrepancy would be one whereby, instead of angiotensin inhibiting renin release, the catabolic products of angiotensin in the intrarenal vascular compartment stimulate renin secretion.If angiotensin catabolism occurs at the pre-glomerular stage, then some of the catabolic products will be lost in the glomerular filtrate.Reduction of renal blood flow, with increased catabolism of angiotensin, would result in a higher level of catabolic products, thus leading to more renin release.On the other hand, ureteral obstruction, while not increasing catabolism, would reduce loss of catabolic products in the glomerular filtrate, with the same effect.This mechanism may also be significant in low-renin hypertension in man, in which renal blood flow is low, but the filtration fraction is high.' 1
CLINICAL VALUE OF PANCREATIC SCANNING
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cellular And Molecular Biology Of The Presynaptic Nerve Terminal
Authors: W. Trimble
Journal: Annual Review of Neuroscience (1991)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Final Results of a Phase I Study of the Fc Engineered CD19 Antibody XmAb®5574 (MOR00208) in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL).
Authors: Jennifer A. Woyach, Farrukh Awan, Ian W. Flinn, Rolondo Enoch, Paul A. Foster, John C. Byrd
Journal: Blood (2012)
The excess incidence of diabetic end-stage renal disease among blacks. A population-based study of potential explanatory factors
Authors: F. L. Brancati
Journal: JAMA (1992)

<h3>Objective.</h3> —To investigate whether the excess incidence of diabetic end-stage renal disease (ESRD) among African Americans could be explained by racial differences in putative ESRD risk factors. <h3>Design.</h3> —Population-based, ecologic study using the 1981 and 1982 Maryland Statewide Household Hypertension Survey for data on risk factor prevalence. <h3>Participants.</h3> —A total of 2.1 million adults residing within the boundaries of the Maryland Regional ESRD Registry, grouped by race and ZIP code into 26 subpopulations. <h3>Main Outcome Measure.</h3> —Incidence rates of treatment for diabetic ESRD between 1980 and 1985 from the Maryland Regional ESRD Registry by subpopulation. <h3>Results.</h3> —Between 1980 and 1985,442 persons entered treatment for diabetic ESRD. At the level of the subpopulation, diabetic ESRD incidence was positively associated with black race (relative risk [RR], 3.42; 95% confidence interval [CI], 2.84 to 4.13), prevalence of diabetes (RR, 2.35; 95% CI, 1.92 to 2.87), prevalence of poorly controlled hypertension (RR, 1.80; 95% Cl, 1.45 to 1.86), lack of a regular source of health care (RR, 1.82; 95% Cl, 1.62 to 2.05), and lower socioeconomic status as indicated by lack of college education (RR, 1.41; 95% CI, 1.32 to 1.52) (all,<i>P</i>&lt;.0001). After adjusting for these risk factors, black race remained strongly associated with the overall incidence of diabetic ESRD (RR, 2.70; 95% Cl, 1.89 to 3.86;<i>P</i>&lt;.0001). Further analyses suggested that this excess risk among blacks was confined to ESRD related to non—insulin-dependent diabetes (RR, 4.80; 95% Cl, 3.09 to 7.46;<i>P</i>&lt;.0001); blacks were at no higher risk than were whites for ESRD related to insulin-dependent diabetes (RR, 0.90; 95% CI, 0.52 to 1.55;<i>P</i>=.70). <h3>Conclusions.</h3> —These data suggest that the excess incidence of diabetic ESRD among blacks is not fully explained by a higher prevalence of diabetes or hypertension in blacks or by racial differences in age, socioeconomic status, or access to health care. Instead, they suggest an increased susceptibility to ESRD resulting from non—insulin-dependent diabetes among blacks as compared with whites. (<i>JAMA</i>. 1992;268:3079-3084)
EDITORIAL
Authors: H. E. Robson
Journal: British Journal of Sports Medicine (1985)

Much of this issue is devoted to the clinical and physiological changes resulting from long-endurance events -marathon running, very long distance running (2,000 miles from Peking to Hong Kong) and cross-country skiing.Also included are case reports on a windsurfing injury, a mishap following arthroscopy, iliopsoas injuries -often not recognised, and a survey into soccer injuries in the young.We have received a very outspoken article -a challenge to our readers, and especially our members in the UK to try to improve sports medicine and fitness assessment by more aggressive action - at local and central Government levels.The author, Mr.
Hepatitis V virus (HBV) cccDNA mini-chromosome transposase-accessible chromatin by atac-sec in infected primary human hepatocytes (PHHs)
Authors: Oceane Floriot, Vincenzo Alfano, Giuseppe Rubens Pascucci, Matteo Pallocca, Francesca De Nicola, Rivoire Michel, Marie-Laure Plissonnier, Mirjam Zeisel, Massimo Levrero, Francesca Guerrieri
Journal: Journal of Hepatology (2020)
Diabetes Mellitus
Authors: Samuel B. Beaser
Journal: New England Journal of Medicine (1952)

Treatment of DiabetesSince the introduction of insulin, both acidosis and symptoms can now be easily avoided. There is, however, incomplete agreement about the aims of therapy — namely, whether or not to achieve normoglycemia. The results of those advocating a completely free diet with insulin have hitherto never been published in sufficient detail. Forsyth et al.78 surveyed the use of such a regime for five years in 47 insulin-treated cases, and, even with a laissez faire attitude, 11 had to be returned to dietary control because of weight gain, rising blood sugar and insulin requirements and frequent reactions. Detailed . . .
Die Leberkuankheiten.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial osteodysplasia
Authors: L. G. Anderson
Journal: JAMA (1972)

Unique abnormalities of bone, especially of the craniofacial skeleton, were found in a young woman with recurrent mandibular fractures and in three of her four sibs. The sibship was the product of a consanguineous marriage. Compared to other genetic disorders of the face, the anatomic defect in these sibs was highly specific for bone. This new syndrome, named "familial osteodysplasia," had an apparent autosomal recessive pattern of inheritance.
Journal of Oral Surgery, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systemic anti-inflammatory mediators in COPD: increase in soluble interleukin 1 receptor II during treatment of exacerbations
Authors: M A Dentener, E C Creutzberg, A M W J Schols, A Mantovani, C van‘t Veer, W A Buurman, E F M Wouters
Journal: Thorax (2001)

BACKGROUND The aim of this study was to test the hypothesis that the chronic inflammatory process present in chronic obstructive pulmonary disease (COPD) is due to a defective endogenous anti-inflammatory mechanism. METHODS Systemic levels of the anti-inflammatory mediators soluble interleukin 1 receptor II (sIL-1RII), soluble tumour necrosis factor receptor p55 (sTNF-R55) and sTNF-R75, and of C reactive protein (CRP) and lipopolysaccharide binding protein (LBP) were analysed in 55 patients with stable COPD (median forced expiratory volume in one second (FEV 1 ) 34% predicted (range 15–78)) and compared with levels in 23 control subjects. In addition, changes in these mediators were studied in 13 patients with COPD (median FEV 1 34% predicted (range 19–51)) during the first 7 days in hospital with an exacerbation of the disease. RESULTS Patients with stable COPD were characterised by a systemic inflammatory process indicated by an increased leucocyte count (7.2 (4.7–16.4) v 4.8 (3.5–8.3) × 10 9 /l), raised levels of CRP (11.8 (1.1–75.0) v 4.1 (0.6–75.0) μg/ml) and LBP (45.6 (8.1–200.0) v 27.9 (14.1–71.5) μg/ml), and moderate increases in both sTNF-Rs. In contrast, the sIL-1RII level did not differ between patients and controls (4.53 (2.09–7.60) v 4.63 (3.80–5.93) ng/ml). During treatment of disease exacerbations, systemic levels of both CRP (at day 3) and LBP (at day 7) were significantly reduced compared with day 1, whereas sIL-1RII levels increased. CONCLUSIONS These data suggest an imbalance in systemic levels of pro- and anti-inflammatory mediators in patients with stable COPD. The increase in the anti-inflammatory mediator sIL-1RII during treatment of exacerbations may contribute to the clinical improvement.
Homosexualismo creador
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VOYAGER: An open-label, randomised, phase III study of avapritinib vs regorafenib in patients (pts) with locally advanced (adv) metastatic or unresectable gastrointestinal stromal tumour (GIST)
Authors: S. Bauer, S. George, Y.-K. Kang, W.D. Tap, T. Zhou, N. Picazio, A.L. Boral, M. Heinrich
Journal: Annals of Oncology (2018)
Impact of Resistance to Thyroid Hormone on the Cardiovascular System in Adults
Authors: Melania Pulcrano, Emiliano Palmieri, Deborah Mannavola, Irene Campi, Danila Covelli, Gaetano Lombardi, Bernadette Biondi, Paolo Beck-Peccoz
Journal: Endocrine Reviews (2009)

ABSTRACT Background The clinical manifestations of resistance to thyroid hormone (RTH) are highly variable, and the impact of RTH on the cardiovascular system has been poorly investigated. Aim The objective of the study was to evaluate the cardiovascular characteristics of 16 untreated and asymptomatic patients with RTH compared with 16 euthyroid healthy controls to define the cardiovascular involvement in RTH syndrome. Patients and Methods Sixteen untreated and asymptomatic RTH patients (eight males; aged 33 ± 12 yr, range 21–45 yr) and 16 controls (nine males; aged 33 ± 5 yr, range 24–42 yr) were enrolled. Clinical data, thyroid status, and echocardiographic results were recorded. Results Heart rate was comparable with that of controls, whereas arterial pressure was higher than controls. Mean interventricular septum diastolic thickness and mean left ventricular (LV) posterior wall diastolic thickness were significantly lower in RTH patients than controls with a consequent significant decrease of the mean LV mass and LV mass indexed by body surface area. Patients also had abnormalities of myocardial relaxation as indicated by a significant increase of peak A and consequent reduction of the early to late ratio. Finally, systemic vascular resistance was significantly higher in RTH patients than controls. Conclusions Our results suggest the presence of cardiovascular alterations in asymptomatic and untreated RTH patients similar to those reported in hypothyroid patients. Our strict selection likely created a bias in the inclusion of a particular type of RTH patients, who could represent a minority of patients with RTH. However, no correlation was found between the type of mutation and cardiovascular characteristics of RTH patients.