tbuckley/cabot-search huggingface dataset:
Abstract 4534: Label free molecular imaging of tumor sections for two and three dimensional tissue classification and pathway mapping
Authors: Emrys A. Jones, Dipa Gurung, Fiona Henderson, Matthew Gentry, Danielle McDougall, Yasmin Shanneik, James Langridge, Adam McMahon, Zoltan Takats
Journal: Cancer Research (2019)

Abstract Mass spectrometry imaging allows for the presence and abundance of a wide range of bio-molecules to be measured directly from tissue sections without the use of labels or tags. This results in the ability to compare the spatial distribution of hundreds of metabolites, lipids, peptides, and proteins within the same section in a single experiment. Desorption electrospray ionization (DESI) mass spectrometry imaging can differentiate and classify tissue types, and associated disease states, by measuring the unique characteristic molecular fingerprints of the tissues1,2. Furthermore, using histologically annotated databases of molecular profiles, unknown tissues can be classified using the mass spectrometry output coupled to machine learning approaches. A major benefit of DESI is that the analyzed sections are left largely unchanged by the process; the sections can subsequently be stained and the results validated by immunohistochemistry or conventional H&amp;E approaches. During DESI fingerprinting analyses, a full mass spectrum on a cell by cell resolution of 20-50µm pixel size is collected. Chemical changes on very small scales can be distinguished and explored, allowing the chemistry of tumor margins and interface zones to be understood through mapping results onto metabolic pathways. As the data in a DESI experiment is collected and stored, multiple interrogations of the data are possible; as new discoveries are made, previously collected data can be retrospectively mined for additional insights. In this study, the three-dimensional chemical heterogeneity of drug dosed spheroids and tumor xenografts was measured with DESI and compared with MRI and PET imaging modalities and with FT-IR spectroscopic techniques. We demonstrate the power of this multi-analytical approach in glioma models and in colorectal and prostrate tumor samples to uncover metabolic and lipidomic changes during disease progression and to reveal the inherent heterogeneity within a tumor. 1. 1. Calligaris, D.Caragacianu, D.Liu, et al; PNAS, 2014, 111, 15185-151892. Guenther, S., Muirhead, L.J., et al, Cancer Res, 2015, 75, 1828-1837 Citation Format: Emrys A. Jones, Dipa Gurung, Fiona Henderson, Matthew Gentry, Danielle McDougall, Yasmin Shanneik, James Langridge, Adam McMahon, Zoltan Takats. Label free molecular imaging of tumor sections for two and three dimensional tissue classification and pathway mapping [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4534.
Classification of Human Ovarian Tumors
Authors: Robert E. Scully
Journal: Environmental Health Perspectives (1987)

Most human ovarian tumors are classified into one of several categories based on presumed histogenesis and direction of differentiation. Separate categories are reserved for neoplasms composed of cells of several origins and for nonneoplastic disorders that simulate neoplasms. Using the World Health Organization Histologic Classification of Ovarian Tumors, histologic features for common and rare human ovarian tumors are described and illustrated.
Medical licensure 1973. Statistical review
Authors: C. H. William Ruhe
Journal: JAMA (1974)

<h3>Candidates Examined by State Licensing Boards</h3> Table 1 is a summary of licenses issued MD candidates by the several licensing boards in the calendar year 1973. The total for that year was 36,462, or 3,062 more licenses than were issued in the previous calendar year. There were 13,094 licenses granted following examination and 23,368 by endorsement of National Board certificates or licenses previously earned in other states. This represented, respectively, a 2% and 14% increase over the previous year's figures. By the close of 1973, all but two states had adopted FLEX as their board examination. The two states yet to adopt the test are Florida and Texas, and it is expected that they will be using FLEX in the near future. Most US medical school graduates continue to qualify for licensure through National Boards. These physicians are not recorded "as candidates for licensure by examination," but appear in the
Effect of clonidine on atrioventricular conduction
Authors: L. E. Kibler
Journal: JAMA (1977)

Clonidine hydrochloride may be a factor in producing a high-grade atrioventricular block. Therefore, careful follow-up with repeated ECG monitoring seems to be indicated when clonidine is given to a patient with suspected cardiac conduction disease, especially if the patient is concurrently receiving digitalis therapy. (<i>JAMA</i>238:1930-1932, 1977)
Impact of Closure of a Sexually Transmitted Disease Clinic on Public Health Surveillance of Sexually Transmitted Diseases—Washington, D.C., 1995
Journal: JAMA (1999)

table, figure omittedALTHOUGH HYPOTHERMIA-RELATED deaths are prevalent during the winter in states that have moderately cold (e.g., Illinois, New York, and Pennsylvania) to severely cold (e.g., Alaska and North Dakota) winters and in states with mountainous or desert terrain (e.g., Arizona, Montana, and New Mexico), hypothermia-related deaths also occur in states with milder climates (e.g., Georgia, Mississippi, and South Carolina), where weather systems can cause rapid changes in temperature.This report summarizes three hypothermia-related deaths in Fulton County, Georgia, representing persons in the highest risk groups for hypothermia; and summarizes hypothermia-related deaths in Georgia during January
A New Test for the Detection of Colorblindness
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sometimes getting into hot water solves a (Legionella) problem
Authors: W. A. Check
Journal: JAMA (1982)

A new sterilization method drastically reduces or eliminates<i>Legionella pneumophila</i>and the Pittsburgh pneumonia agent (<i>Legionella micdadei</i>) from hospital water supplies. Such a control procedure for nosocomial legionnaires' disease and Pittsburgh pneumonia is needed in many hospitals, said Victor Yu, MD, reporting on the method at the American Society of Microbiology's recent Interscience Conference on Antimicrobial Agents and Chemotherapy in Miami Beach. In Yu's and others' experience, the prevalence of these infections is greater than generally thought. Yu and colleagues had previously implicated the hospital water supply as the source of the more than 100 cases of legionnaires' disease and Pittsburgh pneumonia seen at the Veterans Administration Hospital in Pittsburgh during a three-year period. They investigated the ability of the causative organisms to grow in water at various temperatures, then devised a hospital-wide sterilization procedure to eradicate the bacteria from the water supply. A trial of the method began in
Teratogenic effects of asian influenza. A n extended study
Authors: M. G. Wilson
Journal: JAMA (1969)

This report is an extension of the study by Wilson and associates<sup>1</sup>on the teratogenic effects of Asian influenza. The original report included only 126 of the 738 pregnancies with serological data regarding Asian influenza. Since the results of our early report and other investigations<sup>1-7</sup>have not been conclusive regarding the teratogenic effects of Asian influenza, we decided to search for the medical records of the pregnancies in our original cohort which had not been examined. Our original cohort represented a large number of patients with serological evidence of influenza infection. Few studies have had such substantiating serological data.<sup>5,7</sup>Other studies have used primarily medical history for evidence of influenza in the mothers, which is not completely satisfactory. In fact, our data showed that history of influenza and serological titer in the mothers were not correlated. Sixty percent of the mothers who denied having had influenza were
Plasmacytoid Dendritic Cells (PDC) and Th17 Immune Response Contribution in Skin Acute Graft-Versus-Host-Disease (GVHD)
Authors: Florent Malard, Céline Bossard, Patrice Chevallier, Thierry Guillaume, Jacques Delaunay, Eolia Brissot, Jean-François Mosnier, Philippe Saas, Philippe Moreau, Béatrice Gaugler, Mohamad Mohty
Journal: Blood (2012)
Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation
Authors: Jessica M Olsen, Masaaki Sato, Olof S Dallner, Anna L Sandström, Didier F Pisani, Jean-Claude Chambard, Ez-Zoubir Amri, Dana S Hutchinson, Tore Bengtsson
Journal: The Journal of Experimental Medicine (2014)
Serum Enzyme Evaluation in Patients with Heart Infarct
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
School Health Education: A Textbook for Teachers, Nurses and Other Professional Personnel
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regional Anatomy in its Relation to Medicine and Surgery.
Authors: None J. B. H.
Journal: JAMA (1892)

In our notice of the first volume of this recent addition to our already long list of works on anatomy, we expressed our high appreciation of this work, and now that the concluding volume has made its appearance, we can only, reaffirm what we then said of the highly conscientious style of the author, the excellence of the illustrations, and the typographical merit of the book as a whole. It is scarcely too much to say that the present high standing of medicine and surgery as a science is due chiefly to more correct anatomical knowledge, and when we examine the records of the past we find that in every period of the world's history where the study of anatomy languished, medicine and surgery showed little advance and often actual decay, and we sometimes fear that our progressive and pushing age is neglecting anatomy, that foundation of all solid progress,
Communion
Authors: Richard B. Weinberg
Journal: Annals of Internal Medicine (1995)

On Being a Doctor15 November 1995CommunionRichard B. Weinberg, MDRichard B. Weinberg, MDWinston-Salem, NC 27157Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-10-199511150-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I am not an intimidating person, but I found my last patient of the day huddled in the corner of the examining room, as if awaiting an executioner. She was in her midtwenties, and she clutched a sheaf of medical records against her chest like a shield. She had made the appointment to our clinic herself. The face sheet on her chart said “chronic abdominal pain.”I introduced myself, sat down, and began to take her history. She had had severe abdominal pain since her mid-teens, but her description of the pain was so vague that no specific diagnosis sprang ... Author, Article, and Disclosure InformationAuthors: Richard B. Weinberg, MDAffiliations: Winston-Salem, NC 27157Corresponding Author: Richard B. Weinberg, MD, The Bowman Gray School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPatient‐oriented research and the shiny object syndromeCatch them young: grooming a new generation of physicians in IndiaThe Doctor’s New DilemmaThe Role of Emotions in Clinical Reasoning and Decision MakingAn integrated model of clinical reasoning: dual-process theory of cognition and metacognitionTo hear—to say: the mediating presence of the healing witnessMedical StoriesThe epistemically virtuous clinicianMedicine, the Novel, and the Passage of TimeRita Charon, MD, PhD 15 November 1995Volume 123, Issue 10Page: 804-805KeywordsAbdominal painGastroenterology and hepatologyIrritable bowel syndromeLibrariesPharynxRunningStomachThoraxTouchWeight gain ePublished: 15 August 2000 Issue Published: 15 November 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Dye entering subarachnoid space through a bleeding intracranial aneurysm
Authors: F. R. Freemon
Journal: JAMA (1970)

A 46-year-old housewife suffered a fatal subarachnoid hemorrhage from an internal carotid aneurysm. Cerebral angiography performed during this hemorrhage demonstrated angiographic dye coursing up the internal carotid artery, entering the aneurysm, spouting into subarachnoid space, and flowing down the clivus. The roentgenographic demonstration of dye entering subarachnoid space was found in four fatal cases of bleeding aneurysm in the literature. The rarity of this phenomenon probably reflects the evanescence of the actual bleeding from a ruptured intracranial aneurysm.
Statistics and Biomedical Research
Authors: Robert W. Miller
Journal: Environmental Health Perspectives (1979)

Medical observations of leukemia or Hodgkin's disease clusters in time and space have led statisticians to invent techniques to evaluate the probability that these occurrences were due to chance. A difficult computation in human genetics was simplified by a matrix devised by a non-genetical statistician, and readily adapted to newly emerging computer-processing. The experiences exemplify the special opportunity in Japan to enhance research by merging mathematical talent with biomedical observations.
Physician's "Lease-Back" Device in Tax Law
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effect of treatment sequence on overall survival for men with metastatic castration-resistant prostate cancer: A multicenter retrospective study.
Authors: Shingo Hatakeyama, Kazutaka Okita, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama
Journal: Journal of Clinical Oncology (2020)

238 Background: We aimed to evaluate the treatment sequence for patients with metastatic castration-resistant prostate cancer (mCRPC) in real-world practice and compare overall survival in each sequential therapy. Methods: We retrospectively evaluated 146 patients with mCRPC who were initially treated with androgen deprivation therapy as metastatic hormone-naïve prostate cancer in 14 hospitals between January 2010 and March 2019. The agents for the sequential therapy included new androgen receptor-targeted agents (ART: abiraterone acetate or enzalutamide), docetaxel, and/or cabazitaxel. We evaluated the treatment sequence for mCRPC and the effect of sequence patterns on overall survival. Results: The median age was 71 years. A total of 35 patients received ART-ART, 33 received ART-docetaxel, 68 received docetaxel-ART, and 10 received docetaxel-cabazitaxel sequences. The most prescribed treatment sequence was docetaxel-ART (47%), followed by ART-ART (24%). Overall survival calculated from the initial diagnosis reached 83, 57, 79, 37 months in the ART-ART, ART-docetaxel, docetaxel-ART, and docetaxel-cabazitaxel, respectively. Multivariate Cox regression analyses showed no significant difference in overall survival between the first-line ART (n = 68) and first-line docetaxel (n = 78) therapies (hazard ratio: HR 0.84, P = 0.530), between the ART-ART (n = 35) and docetaxel-mixed (n = 111) sequences (HR 0.82, P = 0.650), and between the first-line abiraterone (n = 32) and first-line enzalutamide (n = 36) sequences (HR 1.58, P = 0.384). Conclusions: The most prescribed treatment sequence was docetaxel followed by ART. No significant difference was observed in overall survival among the treatment sequences in real-world practice.
Monitoring genotoxic exposure in uranium mines.
Authors: R J Srám, L Dobiás, P Rössner, D Veselá, D Veselý, R Rakusová, V Rericha
Journal: Environmental Health Perspectives (1993)

Recent data from deep uranium mines in Czechoslovakia indicated that mines are exposed to other mutagenic factors in addition to radon daughter products. Mycotoxins were identified as a possible source of mutagens in these mines. Mycotoxins were examined in 38 samples from mines and in throat swabs taken from 116 miners and 78 controls. The following mycotoxins were identified from mines samples: aflatoxins B1 and G1, citrinin, citreoviridin, mycophenolic acid, and sterigmatocystin. Some mold strains isolated from mines and throat swabs were investigated for mutagenic activity by the SOS chromotest and Salmonella assay with strains TA100 and TA98. Mutagenicity was observed, especially with metabolic activation in vitro. These data suggest that mycotoxins produced by molds in uranium mines are a new genotoxic factor for uranium miners.
Erratum: The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells
Authors: R Thijssen, J ter Burg, G G W van Bochove, M F M de Rooij, A Kuil, M H Jansen, T W Kuijpers, J W Baars, A Virone-Oddos, M Spaargaren, C Egile, M H J van Oers, E Eldering, M J Kersten, A P Kater
Journal: Leukemia (2016)
Metallothionein Synthesis and Degradation: Relationship to Cadmium Metabolism
Authors: Robert J. Cousins
Journal: Environmental Health Perspectives (1979)

Metallothionein is an integral component of the mechanism that regulates the metabolism of cadmium and zinc. The synthesis of this protein can be "induced" by oral or parenteral administration of either metal. The metallothionein mRNA content of liver polysomes is increased shortly after an influx of small amounts of either metal into hepatocytes. After sufficient amounts of this poly (A+) RNA have been synthesized, there is a concomitant increase in metallothionein biosynthesis and metal binding. Unlike synthesis, the degradation of metallothionein is markedly influenced by the species of metal bound. By using in vivo and in vitro techniques, it has been possible to demonstrate that resistance of metallothionein to degradation follows the order: thionein less than zinc metallothionein less than cadmium metallothionein. Moreover, while the polypeptide chains of cadmium metallothionein are degraded, it appears that liberated cadmium ions are quickly incorporated into nascent chains of thionein. The latter explains why the cadmium content of liver and kidney increases with age and environmental exposure. Since both zinc and cadmium bind to metallothionein, it appears that the binding sites provided by this inducible species provide a locus for interaction between zinc, a nutrient, and cadmium, an environmental contaminant.
Commentaire de travail de A. Larghi et al., pp. 1086
Journal: Endoscopy (2007)

See also: Long-term follow-up of complete Barrett’s eradication endoscopic mucosal resection (CBE-EMR) for the treatment of high grade dysplasia and intramucosal carcinomaEndoscopy 2007; 39(12): 1086-1091DOI: 10.1055/s-2007-966788