tbuckley/cabot-search huggingface dataset:
For cancer, the good news is survival; the bad news is incidence
Authors: P. Gunby
Journal: JAMA (1980)

If this year's census form had asked: "Have you ever had cancer?" a clearer picture might then emerge of the number of persons in the United States who have had or have cancer and continue to survive. The National Cancer Institute (NCI) and the American Cancer Society (ACS) estimate that more than 3 million persons living in this country have a history of cancer and that at least 2 million of them received the initial diagnosis five or more years ago. These figures do not include skin cancers other than malignant melanoma; estimates of the number of persons who have had or have basal, squamous, or basosquamous cell carcinomas range from 400,000 to nearly 10 million. This year, the ACS predicts that some 785,000 persons in this country—20,000 more than in 1979 and 85,000 more than in 1978—will receive diagnoses of cancer for the first time. About one in three
Hunterian pilgrimage.
Authors: R S Murley
Journal: BMJ (1971)

In June 1760, when he was 32 years of age, the health of the great John Hunter was so seriously affected by overwork that he was advised "to take a complete rest, to go abroad (and) to occupy his mind with less exacing pursuits.""After a short period of inactivity away from his brother William's dissecting room at Covent Garden John
Rebuilding Haiti’s Health System
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P3-12-12: Impact of regional nodal irradiation for breast cancer patients with supraclavicular and/or internal mammary lymph node involvement: A multicenter, retrospective study (KROG 16-14)
Authors: K Kim, Y Jeong, KH Shin, JH Kim, SD Ahn, SS Kim, C-O Suh, YB Kim, DH Choi, W Park, J Cha, M Chun, DS Lee, SY Lee, JH Kim, HJ Park
Journal: Cancer Research (2019)

Abstract Purpose: To evaluate the treatment outcomes of radiotherapy (RT) for breast cancer with ipsilateral supraclavicular (SCL) and/or internal mammary (IMN) lymph node involvement. Methods: A total of 353 patients from 11 institutions were included. One hundred and thirty-six patients had SCL involvement, 148 had IMN involvement, and 69 had both. All patients received neoadjvant systemic therapy followed by breast conserving surgery or mastectomy, and postoperative RT to whole breast/chest wall. As for regional lymph node irradiation, SCL RT was given to 344 patients, and IMN RT to 236 patients. The median RT dose was 50.4 Gy. Results: The median follow-up duration was 61 months (range, 7-173). In-field progression was present in SCL (n=20) and/or IMN (n=7). The 5-year disease-free survival (DFS) and overall survival rates were 57.8% and 75.1%, respectively. On multivariate analysis, both SCL/IMN involvement, number of axillary lymph node ≥4, triple negative subtype, and mastectomy were significant adverse prognosticators for DFS (p = 0.022, 0.001, 0.001, and 0.004, respectively). Regarding the impact of regional nodal irradiation, SCL RT dose ≥54 Gy was not associated with DFS (5-yr rate, 52.9% vs. 50.9%, p = 0.696) in SCL-involved patients, and the receipt of IMN RT was not associated with DFS (5-yr rate, 56.1% vs. 78.1%, p = 0.099) in IMN-involved patients. Conclusion: Neoadjuvant chemotherapy followed by surgery and postoperative RT achieved an acceptable in-field regional control rate in patients with SCL and/or IMN involvement. However, a higher RT dose to SCL or IMN RT was not associated with the improved DFS in these patients. Citation Format: Kim K, Jeong Y, Shin KH, Kim JH, Ahn SD, Kim SS, Suh C-O, Kim YB, Choi DH, Park W, Cha J, Chun M, Lee DS, Lee SY, Kim JH, Park HJ. Impact of regional nodal irradiation for breast cancer patients with supraclavicular and/or internal mammary lymph node involvement: A multicenter, retrospective study (KROG 16-14) [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P3-12-12.
TUBERCLE BACILLI AND LIVING CELLS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB1038 High Costs for Health System of Misdiagnosing Osteoarthritis as Rheumatoid Arthritis
Authors: D. Buitrago-Garcia, C. Castro, P. Santos-Moreno, L. Villarreal, G. Ballesteros, J. Bello, E. Castillo, R. Giraldo, D. Gomez, A. Aza, A. Lopez, A. Cardozo, N. Palacio
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> There are an important number of patients with osteoarthritis (OA) that are misdiagnosed as rheumatoid arthritis (RA) in general practice in Colombia. They are treated as such with disease modifying anti-rheumatic drugs (DMARDs), leading to higher economic costs for health system. <h3>Objectives</h3> The aim of this study was to calculate the possible direct economic costs of the care of OA patients misdiagnosed as RA in a 48 month period in a cohort of patients derived to a specialized RA center in Colombia. <h3>Methods</h3> A descriptive cross sectional study was performed. Patients derived during a 48 month period to a RA specialized center with presumptive diagnosis of this disease and found finally diagnosed with OA were included in analysis. Each patient was evaluated to confirm or rule-out diagnosis of RA as follows: a rheumatologist fulfilled a complete medical record, including joint counts; it was assessed rheumatoid factor and anti-citrullinated antibodies, and other laboratories depending on each case. Also were made x-rays of hands and feet, and in some cases of persistent doubt about the diagnosis was requested comparative MRI of hands or/and feet. Then we described the direct costs of care in Colombian pesos (COP) of these false-positive RA patients assuming an average of 4 visits/year to general practitioner (8.400 COP/medical appointment), 2 visits/year for physiatrist and orthopedics (33.995 COP/ medical appointment) and 4 set/year of conventional laboratories (92.161 COP/set). Cost of medication doses were calculated for an average use of methotrexate, sulfasalazine, chloroquine and prednisolone (200.840 COP/monthly). Indirect costs were not calculated. <h3>Results</h3> We found 2930 OA patients misdiagnosed as RA in a period of 48 months. For each patient we calculated 33.600 COP/year for general practitioner visits, 135.980 COP/year for specialized medicine visits, 368.644 COP/year for laboratory sets and 2.431.248 COP/year for medications. This leads to a total cost of 2.969.472 COP/year per patient. Given a total of 2930 misdiagnosed patients cost rise to 8.700.552 million COP/year ($2,900,184 US dollars/year). <h3>Conclusions</h3> There is an important economic implication of the misdiagnosis of OA as RA, being this the most frequent mistake in the diagnosis of this disease. The implementation of educational programs for health care primary physicians and specialized RA centers where a process of screening diagnosis is made could save this amount of money for the health system in Colombia. <h3>Disclosure of Interest</h3> None declared
T-DM1 “Smart Bomb” Hits Breast Cancer Targets
Journal: Cancer Discovery (2012)

Abstract Women with HER2-positive locally advanced or metastatic breast cancer who were previously treated with a taxane and trastuzumab showed significant improvement when treated with the antibody-drug conjugate (ADC) trastuzumab emtansine (T-DM1), among the first in a wave of anticancer ADCs.
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Authors: Elizabeta Nemeth, Seth Rivera, Victoria Gabayan, Charlotte Keller, Sarah Taudorf, Bente K. Pedersen, Tomas Ganz
Journal: Journal of Clinical Investigation (2004)

Hypoferremia is a common response to systemic infections or generalized inflammatory disorders. In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin are largely unknown. Our studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL-6–hepcidin axis is responsible for the hypoferremia of inflammation.
Prevalence of osteoporosis in high- and low-fluoride areas in North Dakota
Authors: D. S. Bernstein
Journal: JAMA (1966)

Roentgenograms of the lateral lumbar area of the spine were obtained from 1,015 subjects over age 45 who were residing in North Dakota. Three hundred lived in an area where the fluoride content of the water supply was high, 4 to 5.8 ppm, and 715 in an area where it was low, 0.15 to 0.3 ppm. Evidence of osteoporosis, reduced bone density, and collapsed vertebrae was substantially higher in the low-fluoride area, especially in women. Visible calcification of the aorta was significantly higher in the lowfluoride area, particularly in men. Limited information on milk and cheese consumption does not indicate that differences in calcium consumption are a significant factor. Fluoride consumption is important in the prevention of osteoporosis and may also play a significant role in preventing calcification of the aorta.
Medicolegal Rounds
Authors: Angela Roddey Holder
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STANDARD PREPARATIONS.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperventilation syndrome
Authors: M. THOMAS
Journal: Thorax (2000)

We were interested to read of the association between paracetamol use and asthma in adults reported by Shaheen et al. 1 We recognise that the link is not causal and that further randomised trials are needed to clarify this link.In their paper they comment that they have controlled for potentially confounding factors.We were concerned that one of their definitions for "asthmatic" was the positive answer to the question "Have you been woken by an attack of shortness of breath over the last 12 months?".The association they have shown was with people who use paracetamol weekly or daily.We do not believe that there has been an attempt to control for confounding factors, particularly anxiety leading to headaches and symptoms of breathlessness and hyperventilation.We would encourage researchers taking this mat-ter further to consider this in their study designs.
Puzzles
Authors: Hugh H. Hussey
Journal: JAMA (1975)

Some persons are addicted to crossword puzzles; others can take them or leave them (preferably the latter). Yet, there's a lot to be said for the puzzles. The solvers learn words unknown to all except fellow fans. Of course, most of the words they learn are difficult to use in everyday conversation. For example, you discover a dandy new word like "glout," a sulky. You are not sure whether it is something horse-drawn for riding or a state of mind. So, you consult a dictionary and discover that your abridged<i>Webster's</i>doesn't even list the word. Therefore, when the right time comes, you somehow work "glout" into a friendly conversation at cocktail time. Your listeners are not quite sure whether you said "gout," or something else; and you gloat about glout, which is a "sulky" even if you still don't know that a glout is something you ride in or
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings2 October 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-7-200110020-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyAcute Myocardial Infarction and Other Acute Ischemic Syndromes2nd edition. RM Califf, ed. 232 pages. Philadelphia: Current Medicine; 2001. $125.00. ISBN 1573401595. Order phone 215-574-2266.The Adult with Tetralogy of FallotMA Gatzoulis and DJ Murphy Jr, eds. 95 pages. Armonk, NY: Futura; 2001. $30.00. ISBN 0879934905. Order phone 800-877-8761.Atlas of Atherosclerosis: Risk Factors and Treatment2nd edition. PW Wilson, ed. 269 pages. Philadelphia: Current Medicine; 2000. $125.00. ISBN 1573401374. Order phone 215-574-2266.Basic Dysrhythmias: Interpretation and Management3rd edition. RJ Huszar. 544 pages. St. Louis: Mosby–Year Book; 2002. $37.00. ISBN 0323012442. Order phone 314-872-8370.Cardiology Secrets2nd edition. OV Adair, ed. 343 ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 October 2001Volume 135, Issue 7Page: B1KeywordsComputed axial tomographyInterleukinsPrevention, policy, and public health ePublished: 2 October 2001 Issue Published: 2 October 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Polymyositis Associated with Thyroid Carcinoma: Report of a Case
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biomedical Discoveries
Authors: Joan Stephenson
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adrenal Insufficiency
Authors: Wolfgang Oelkers
Journal: New England Journal of Medicine (1996)

The hypothalamic–pituitary–adrenal axis has an important role in the body's ability to cope with stresses such as infections, hypotension, and surgery. The hypothalamus is subject to regulatory influences from other parts of the brain, especially the limbic system. The hypothalamic hormones corticotropin-releasing hormone and arginine vasopressin are important stimulants of corticotropin secretion by the anterior pituitary. In this gland, the action of the hypothalamic hormones is amplified so that a much larger number of corticotropin molecules is secreted. Similarly, in the adrenal cortex the action of corticotropin is amplified; a plasma corticotropin concentration of approximately 25 pg per milliliter (5.5 . . .
PRESIDENT WILSON RISES TO AN EMERGENCY
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transgenic Animals
Authors: Alan R. Shuldiner
Journal: New England Journal of Medicine (1996)

The photograph of a giant transgenic mouse created by the overexpression of growth hormone, which appeared on the cover of Nature in 1982, represented a landmark in molecular biology. The technology for producing transgenic animals was made possible by the coalescence of fundamental discoveries in several disciplines over a period of decades. These discoveries led to important insights into the hormonal control of reproduction in mammals and the development of techniques to harvest, manipulate, and reimplant eggs and early embryos — techniques that are used today by in vitro fertilization clinics throughout the world. Another important development was the use . . .