tbuckley/cabot-search huggingface dataset:
The Medical Department of the United States Army in the World War. Volume XIV. Medical Aspects of Gas Warfare. Prepared Under the Direction of Maj. Gen. M. W. Ireland, the Surgeon General.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Depressive symptoms and risk of cancer
Authors: B. H. Fox
Journal: JAMA (1989)

Clinical observations that began centuries ago and extend to the present describe an association between depressive symptoms and cancer. This discussion focuses on such symptoms, not clinical depression. One could not conclude with confidence from studies done during the last 40 years whether depression would predict an excess risk of later cancer. Most of the earlier studies suffered from faulty design, small samples, failure to adjust for confounders, and a number of biases. The first large prospective study on a normal cohort was that of Shekelle et al,<sup>1</sup>appearing in 1981. They gave 2020 men the Minnesota Multiphasic Personality Inventory and determined the group's cancer mortality over 17 years. Men who scored highest, among that measure's scales, on the Depression scale showed a relative risk of 2.3 after controlling for several relevant variables; that is, a risk of death from cancer 2.3 times that of men whose depression score
All Ears
Authors: Ian Wicks
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In This Issue
Authors: Ruth Williams
Journal: Circulation Research (2014)

Atherosclerosis Induced by PCsK9 Gene Transfer (p 1684) Bjørklund et al describe a faster and easier method for inducing atherosclerosis in mice.Genetically engineered mice lacking the Apoe or Ldlr gene are the go-to models for studying hypercholesterolemia and atherosclerosis.However, numerous rounds of breeding are required to study the effects of other genetic modifications in these strains.Such procedures are not only time consuming and costly, but they involve the use of a large number of animals.Now Bjørklund and colleagues have devised a new method to induce hypercholesterolemia and atherosclerosis in wild-type mice and hamsters by a single injection of a viral vector encoding proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein known to increase levels of LDL, or "bad" cholesterol in humans and mice.When placed on a high-fat diet the injected animals displayed persistent hypercholesterolemia and atherosclerosis.The team then used this technique to examine the effect of diabetes on atherosclerosis.They found that when injected with the PCSK9 vector, diabetic mice developed more severe hypercholesterolemia and atherosclerosis than non-diabetic mice.The speed and simplicity of this new approach should expedite atherosclerosis research not only in mice and hamsters, but other mammals as well.
Abstract 21318: Long Non-Coding RNA Promotes Endothelial Homeostasis Through Chromatin Remodeling
Authors: Zhen Chen, Yifei Miao, Feng-Mao Lin
Journal: Circulation (2017)

Serving as a bioactive interface between the blood flow and the vessel wall, the vascular endothelium senses mechanical and chemical signals under various physiological and pathophysiological conditions, such as atherosclerosis and diabetes complications. Among the extensive mechanistic studies on multiple molecular levels, it is unclear whether and how chromatin remodeling plays a role in regulation of endothelial gene expression. In this study, we explored the role of long non-coding RNAs (lncRNAs)-mediated chromatin remodeling in endothelial transcriptome. Combining RNA-sequencing, chromosome conformation capture technologies, and systems biology approaches, we identified in human endothelial cells (ECs) a set of long non-coding RNAs (lncRNAs) that are differentially regulated by endothelial protective versus detrimental stimuli. Mechanistically, these lncRNAs can act as scaffolds to enhance transcription of key endothelial molecules through mediating the long-range DNA interaction and transcription factor binding. Suppression of these lncRNAs with locked nucleic acid-GapmerRs or CRISPR-Cas9-mediated genomic editing leads to altered endothelial transcriptome and phenotypes. Using mouse models, we demonstrate that some of these lncRNAs and their molecular functions may be conserved across-sepcies. Furthermore, these lncRNAs can be detected in the circulating exosomes, suggesting that they may bear diagnostics and therapeutics potentials. Collectively, these lncRNAs play an essential role in epigenetic regulation of endothelial functions; the identification of these lncRNAs can have significant impacts on understanding of diseases involving endothelial dysfunction.
Spitz nevi
Authors: Philip E. Shapiro
Journal: Journal of the American Academy of Dermatology (1993)

Journal of the American Academy of Dermatology Volume 29, Number 4 as is usual in DDD, an increased number ofmelanocytes was not found in our patient, unlike the patient of Kameyama et aI.Kameyama and co-workers suggest that azelaic acid more easily penetrates active melanocytes; perhaps in our patient the melanocyteswere in a less active state.It is also possiblethat the pathogenetic mechanisms in DDD and RAPK differ, especiallywith regard to tyrosinase activity and the regulation of melanocyte activity.A trial on a larger populationcoulddeterminethe responsiveness to azelaic acid of patients with reticulate pigmentation and givemore information about the pathogenesis of this interesting group of disorders.
Notes on the Medical Treatment of Disease for Students and Young Practitioners of Medicine
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rupture of the Aorta After Mechlorethamine HCl Infusion of a Bronchial Artery
Authors: Richard J. Steckel
Journal: JAMA (1967)

PERCUTANEOUS catheterization of the bronchial arteries by the Seldinger technique has been described and is being investigated actively in several centers.<sup>1-7</sup>A special catheter is introduced percutaneously into the femoral artery and is passed proximally in the aorta to the level of the aortic arch. The small bronchial artery orifices arising from the arch or proximal descending aorta can then be entered by the probing catheter tip under fluoroscopic control. This procedure is easily accomplished in the radiology department, and only local anesthesia at the femoral catheterization site is required. Since pulmonary neoplasms, both primary and metastatic, derive their blood supply from the bronchial arteries and not from the pulmonary artery, the technique opens broad new possibilities for the arteriographic diagnosis of pulmonary tumors and for palliative infusions of these tumors with chemotherapeutic agents.<sup>1-9</sup>The following case report describes a fatal complication arising from the infusion of a
Humanitarian Medicine
Journal: JAMA (1971)

Herbert Spencer, who flourished in Victorian days, and whose philosophical system embraced everything within science, biology, morality, and religion, remarked once of nature, "... how careful of the type she seems, how careless of the single life." It has been the characteristic of medicine to be careful of the single life, of which nature has been so careless. This keystone interest in the individual within the society is probably the basis for the success of public health maneuvers. National health guarantees, preventions or eradication of infections, drives against cancers, concerns for crippled children, heart disease, blindness, mental retardation—the endless list of man's imperfections—are successful or effective not alone, because of the general improvement of health, but because they get through to the single life that nature so cruelly neglects. No reasonable man could elect a return to nature's medicine. Within the maelstrom of attack upon every physical imperfection in the body
Officials of the Association 1987-1988
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Benign Surgical Lesions of the Cecum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EPITOME OF CURRENT MEDICAL LITERATURE
Journal: BMJ (1925)

describe a new form of epittemic encephalitis which does not appear to have been isolated before, and does not in any way resemble the ordinary forms of the disease.The %irus in these cases seems to attack exclusively or principally 1 he peripheral motor and sensory neur ons, and the affection appears to correspond to a menlngo-radicuio-neuritic process.The onset may be sudden, the patient becoming paralytic 'vithin a few hours, or it may take a few days to develop.Painful symptoms may occur at this stage.At the height of the disease the affection presents the ordinary phenomena of p)olyneuritis, but the mijost striking feature is the widespread eharacter of the paralysis, which often involves the sphincters, tipper limbs, and sometimjes even the face, although this (listribution bears no relation to the intensity of the motor defect.Pressure on the nerves and musc:es is generally painful.On the other hand, no anaesthesia was ever noted.
Mitral regurgitation
Authors: R. E. Greene
Journal: JAMA (1968)

Dr. Thomas E. Shea: This 47-year-old housewife entered the hospital because of a heart murmur and shortness of breath. She had been in good health until five years before admission, when she noted the gradual onset of exertional dyspnea and occasional episodes of wheezing. She had no acute problems until one year later when she developed fever and cough for which she was treated with antibiotics. Roentgenograms of the chest at that time were interpreted as showing pulmonary congestion and possibly pneumonia. Physical examination on admission to this hospital revealed the thyroid to be enlarged. The lungs were clear and the heart was moderately enlarged. The cardiac rhythm was regular at 120 beats per minute. There was a grade 2 systolic murmur and a grade 2 diastolic rumble located at the apex. The second pulmonic sound was accentuated. There was no presystolic accentuation, nor was there an opening snap. The
SPECIFICITY OF THE PROTEIN MOLECULE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEW
Journal: British Journal of Dermatology (1949)

British Journal of DermatologyVolume 61, Issue 1 p. 30-30 BOOK REVIEW First published: January 1949 https://doi.org/10.1111/j.1365-2133.1949.tb11315.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume61, Issue1January 1949Pages 30-30 RelatedInformation
Fibrosarcoma of Superficial Soft Tissue Origin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Head to the Islands for a Longer, Healthier Life Span, Says Study
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phenmetrazine psychosis.
Authors: P. S. Nemetz
Journal: BMJ (1968)

7 September, p. 597) suggests that "the term drowning should be used to denote the process resulting from submersion in water in which there is loss of conscious- ness and threat to life."Within the com- mon use of "drowning" and the above definition of the term there is an elision,- immersion hypothermia.Keatingel showed in the Lakonia disaster that " hypothermia led to the deaths of most, perhaps as many as 113 out of 124 who died."He has also stated that "approximately 1,000 people die from immersion in British coastal and inland waters every year.
The Management of Hyperlipoproteinemia
Authors: David D. Norenberg
Journal: JAMA (1986)

<h3>To the Editor.—</h3> It seems so logical, given the mass of epidemiologic data that correlates elevated cholesterol values with increased incidence of coronary disease in populations, that cholesterol must be the primary culprit and that a diet or drug that lowers cholesterol levels will a priori lower risk of death. If this is true, why haven't we been able to prove it? The article by Hoeg et al<sup>1</sup>in the Jan 24/31 issue of<i>JAMA</i>is the position of believers. My own view of the data is more agnostic. The real question is very straightforward: does diet or drug therapy to lower lipid levels save lives? An affirmative answer remains elusive. If the diet or drug causes as many noncardiac deaths as it prevents cardiac deaths, that's no good. We need safe therapy with proved efficacy; we need a positive prospective study. There is still no prospective intervention trial that
Continine Analytical Workshop Report: Consideration of Analytical Methods for Determining Cotinine in Human Body Fluids as a Measure of Passive Exposure to Tobacco Smoke
Authors: Randall R. Watts, John J. Langone, George J. Knight, Joellen Lewtas
Journal: Environmental Health Perspectives (1990)

A two-day technical workshop was convened November 10-11, 1986, to discuss analytical approaches for determining trace amounts of cotinine in human body fluids resulting from pas- sive exposure to environmental tobacco smoke (ETS).The workshop, jointly sponsored by the U.S. Environmental Protection Agency and Centers for Disease Control, was attended by scientists with expertise in cotinine analytical methodology and/or conduct of human monitoring studies related to ETS.The workshop format included technical presentations, separate panel discussions on chromatography and immunoassay analytical approaches, and group discussions related to the quality assurance/quality control aspects of future monitoring programs.This report presents a consensus of opinion on general issues before the workshop panel participants and also a detailed comparison of several analytical approaches being used by the various represented laboratories.The salient features of the chromatography and immunoassay analytical methods are discussed separately.