tbuckley/cabot-search huggingface dataset:
RESEARCH FOR A NON-HABIT-FORMING SUBSTITUTE FOR MORPHINE
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Postcholestatic alkaline phosphatase activity after relief of bile duct obstruction in the rat
Authors: A Wielandt
Journal: Hepatology (1993)

The effects of obstructive cholestasis on the activity of alkaline phosphatase have been extensively studied in serum and liver tissue. However, very little is known about the activity of this enzyme in the postcholestatic condition after relief of the biliary obstruction. The purpose of this study has been to characterize alkaline phosphatase activity in serum, liver and bile in the postcholestatic period and to relate it to changes in bile acid secretory rate. Serum activity and biliary secretory rates of alkaline phosphatase were markedly increased in rats subjected to a reversible obstructive cholestasis for 24 hr or 48 hr and progressively declined along the postcholestatic period to values not significantly different from those of control rats within 48 hr. A significant direct linear relationship between the biliary secretory rates of enzyme activity and bile salts was apparent both in cholestatic groups and in the control groups. The slope of the regression line (units of alkaline phosphatase secreted per micromole of bile salts) was 1.5-fold to 3-fold higher in cholestatic animals. Remarkably, a positive y-intercept of regression lines suggested that a significant fraction of the enzyme was secreted independently of bile salts; this fraction was 18-fold and 34-fold greater in 24-hr and 48-hr cholestatic rats, respectively, compared with that in controls. Sodium taurocholate administered intravenously, either as a bolus or as an infusion at increasing submaximal rates, resulted in parallel increases of bile salt and alkaline phosphatase secretory rates into bile. The enzyme activity secreted per micromole of taurocholate was significantly greater in cholestatic than in control rats. In the liver tissue, increased homogenate and canalicular membrane alkaline phosphatase activity in 24-hr cholestatic rats progressively decreased to reach control values 48 hr after relief of biliary obstruction. This study demonstrates that a marked increase of alkaline phosphatase secretion into bile occurs in the postcholestatic condition. It presents further evidence for bile acid dependency of this process and demonstrates that more enzyme is secreted per micromole of bile salt in the postobstructive condition, probably related to the increased enzyme content in the liver and to an increased lability of the canalicular membrane enzyme to the solubilizing effect of secreted bile acids in cholestatic rats. In addition, this study suggests that alkaline phosphatase might be normally secreted into bile by another process independent of bile salts, which appears to be quantitatively more important in cholestatic than in control rats. (HEPATOLOGY 1993;18:179–187).
Voluntary Organ Donation: Autonomy... Tragedy
Authors: Richard A. Kunin
Journal: JAMA (1993)

<h3>To the Editor.</h3> —My son was still alive on life support when we said our goodbyes and left him 13 years ago. Neurology training had prepared me to accept the idea of brain death. My son's retinal veins showed air bubbles, indicating severe anoxia. He had been struck a single blow to the occiput and it was a mortal blow. He had two cardiac arrests before arrival at the hospital and was in a coma, unable to breathe on his own, when I arrived 4 hours later. I accepted the fact of his death. The neurosurgeon assured me he would be blind and a vegetable if he did survive, so I didn't push for electroencephalographic evidence. I don't think that was a mistake. But I realize now, while reading Youngner and Arnold's article<sup>1</sup>13 years later, that my family just walked away from Tony in limbo, giving in to
Provision of specialized palliative care in a multiprofessional network.
Authors: Jens Hermann Papke
Journal: Journal of Clinical Oncology (2014)

e20545 Background: In Germany specialised palliative care in outpatient setting is financed by health insurances since 2007. Home Care Sachsen e.V. is a specialised palliative care provider working with two teams including qualified nurses, physicians and social workers in closely cooperation with general practitioners and nursing services. We report about the results of our work in a rural area around Dresden in Saxony, Germany. Methods: Our data were collected prospectively with the PalliDoc software. Results: Between 2011 – 2013 Home Care Sachsen e.V. served for 1,572 pts (888 m, 684 f); 93% with an oncologic disease. Median age was 71 y, Karnofsky index was 40%, median caring time 27 days. In this time, 25% of our pts had one stay in hospital, 8% two and 4% three and more. 63% had no stays in hospital. At least 1,271 pts. died: 65% at home; 9% in nursing homes and hospices; 15% in palliative care units and 11% in hospital. Conclusions: Mean home death rate of oncologic pts without intervention in Germany is about 44% (Papke J, Koch R: Places of Death from Cancer in a Rural Location. Onkologie (2007) 30, 105-08). This proportion could be enhanced considerably with outpatient palliative care. Providing of specialised palliative care with a multiprofessional team is effective to increase the rate of dying at home and to fulfill one of the strongest wishes of pts in a palliative situation.
The Torch of Life: A Key to Sex Harmony.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABCB4/MDR3 gene mutations in young patients with symptomatic cholelithiasis
Authors: Catarina Gouveia, Margarida Flor de Lima, Flávio Pereira, Bruno Rosa, Maria Antonia Duarte, António Banhudo, José Cotter, Alexandre Ferreira, Mariĺia Cravo, Joana Nunes
Journal: Journal of Hepatology (2020)
Nordiska specialitetskommissionens årsberättelse, 1929.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cetuximab, docetaxel, and cisplatin (TPEx) as first-line treatment in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): First results of phase II trial GORTEC 2008-03.
Authors: J. Guigay, J. Fayette, A. Dillies, C. Sire, J. N. Kerger, I. Tennevet, J. H. Machiels, S. Zanetta, Y. Pointreau, L. Bozec Le Moal, L. Brugel Ribere, S. Henry, S. Temam
Journal: Journal of Clinical Oncology (2011)

5567 Background: Cetuximab in combination with platinum and 5FU has become a standard in first-line treatment of patients (pts) with R/M SCCHN. Cetuximab and taxane combinations have shown promising activity. This multicenter phase II study evaluates the efficacy and safety of cetuximab, docetaxel and cisplatin combination (TPEx) as first-line treatment in pts with R/M SCCHN. Methods: Pts were required to have WHO PS 0-1, no prior systemic therapy for R/M SCCHN, cumulative dose of cisplatin less than 300 mg/m² and no prior anti-EGFR therapy. Pts received docetaxel 75 mg/m² day 1, cisplatin 75 mg/m² day 1 and cetuximab (400 mg/m² on day 1 of cycle 1 then 250 mg/m² weekly), repeated every 21 days x 4 cycles then followed by cetuximab 500 mg/m² every 2 weeks as maintenance therapy until disease progression or unacceptable toxicity. G-CSF support with lenograstim 150 microgr./m²/day was delivered after each cycle of chemotherapy. Response was assessed every 6 weeks, according to RECIST. The primary endpoint was objective response rate (ORR) at 12 weeks. Secondary endpoints were safety, best overall response, progression-free survival, overall survival and biomarkers. A Simon two-stage design was used with OR in more than 9/30 pts needed before continuing accrual to the final 54 pts. Results: 51 pts have been enrolled to date and 33 pts could be evaluated for primary endpoint: all male, median age 55 years (48-68), 50% metastatic.ORR at 12 weeks was 48.5%. Partial response, stable disease and progression were respectively found in 16 pts (PR 48.5%), 15 pts (SD 45.5%) and 2 pts (PD 6%). There were 18 pts (54.5%) with PR as best response. Treatment related toxicities included G4 neutropenia (n=3). Grade 3 events were skin rash (n=5), hypersensitivity (n=3), mucositis (n=1), fatigue (n=1) and febrile neutropenia (n=1). Alopecia was common. No death was related to study treatment. Conclusions: Preliminary efficacy analysis based on response rate demonstrates that TPEx regimen has encouraging activity as first-line treatment in pts with R/M SCCHN. Toxicity is manageable with G-CSF support. Trial accrual continues up to 54 pts.
BBS volume 4 issue 1 Cover and Front matter
Authors: Victor Denenberg, With Commentary, J Bradshaw, ; Bures, O Buresova, J Krivanek, R Collins, G Corballis, C Ettlinger, R Giurgea, ; Lehman, A Levy, M Jeeves, M Myslobodsky, J Nelsen, R Goldstein, D Puccetti, T Robinson, B Robinson, L Becker, J Rogers, L Warren, N Nettleton, P Bertelson, ; Brownell, H Gardner, M Bryden, F Allard, A Carmon, G Cohen, M Coltheart, W Cooper, M Corballis, G Gainotti, L Harris, J Carr, W Marshall, M Mckeever, R Nottebohm, M Puccetti, P Studdert-Kennedy, M Tallal, Roland Puccetti, R Anderson, J Gonsalves, J Bogen, J Brown, P Churchland, R Davidson, J Eccles, N Geschwind, M Green, R Joynt, J Ledoux, M Gazzaniga, J Margohs, C Marks, ; Robinson, E Weinstein, V Wilkes, Timothy Johnston, T Alley, R Shaw, G Barlow, E Glickman, P Bateson, W Charlesworth, J Garcia, T Ghiselin, R Gonzalez, M Yarczower, J Hailman, R Hinde, J Kalat, A Kamil, J Kruse, E Reed, J Lachman, R Lachman, A Logue, J Malone, J Nevin, L Petrinovich, H Plotkm, F Odling-Smee, H Rachlin, S Revusky, ; Rozin, W Schleidt, S Schwartz, W Welker, Stcvan Harnaci, Lielaine Randerson, David Premack
Journal: Behavioral and Brain Sciences (1981)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Dental Amalgam Report Issued
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Small intestinal scleroderma with malabsorption and pneumatosis cystoides intestinalis. Report of three cases
Authors: W. E. Meihoff
Journal: JAMA (1968)

Three patients had scleroderma of the gastrointestinal tract manifested by chronic partial small bowel obstruction and pneumatosis cystoides intestinalis. In two of them rupture of cysts caused pneumoperitoneum. Melabsorption of fat, vitamin B<sub>12</sub>, and xylose led to rapid wasting. Massive jejunal contamination with bacteria was present in two of the patients, and in these two the steatorrhea was successfully treated with appropriate antibiotics. Repeated courses of antibiotics were necessary because of recurrent diarrhea and steatorrhea. Pneumatosis cystoides intestinalis has not been emphasized previously as a complication of small intestinal scleroderma. The origin of the cyst gas is unknown, but the lumen of the gastrointestinal tract seems the most likely source. Pneumatosis cystoides intestinalis is probably a late complication and its presence suggests a poor prognosis.
Renal Failure: The Agony and the Ecstasy
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resident Work Hours and the American Board of Medical Specialties-Reply
Authors: Peyton E. Weary
Journal: JAMA (1991)

<h3>In Reply. —</h3> I wish to point out that the ABMS, in vetoing the general requirement language with respect to resident work hour limitations, does not condone or endorse excessive work hours for resident trainees and acknowledges the need for appropriate times to be set aside for leisure, study, and regeneration. On the other hand, the ABMS feels that it is entirely inappropriate to make specific statements in the section on general requirements about work hours that may not be applicable to all specialties. It would have been preferable to adhere to the original language proposed by the Residency Review Committee Chairmen's Council, which stated: Assignments of in-hospital duty hours and call schedules must ensure that residents are not regularly required to perform excessively prolonged periods of duty and that they have adequate opportunities to rest and study. The actual number of hours worked by residents may vary according to
Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy
Authors: Yi Wang, Cenglin Xu, Zhenghao Xu, Caihong Ji, Jiao Liang, Ying Wang, Bin Chen, Xiaohua Wu, Feng Gao, Shuang Wang, Yi Guo, Xiaoming Li, Jianhong Luo, Shumin Duan, Zhong Chen
Journal: Neuron (2017)

(Neuron 95, 92–105; July 5, 2017) After publication, we noticed an error in Figure S5A, which was inadvertently introduced during the reformatting of the final version of the manuscript. The western blot for KCC2 in the CA3 field of hippocampus (Figure S5A, right side) erroneously displayed the same western blot as that shown in Figure S5B, which reflects expression of KCC2 in the subiculum. This error has no effect on any of the statistics or conclusions in the paper and the revised figure (Figure S5A) has now been corrected online. The authors apologize for the mistake and any confusion this may have caused. Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe EpilepsyWang et al.NeuronJune 22, 2017In BriefThe subiculum is crucially involved in spreading and generalizing hippocampal seizures. Wang et al. demonstrated depolarized GABAergic signaling caused by the change of chloride transporters in subicular microcircuit mediates secondary generalized seizures in temporal lobe epilepsy in vivo. Full-Text PDF Open Archive
Ulcerative Sarcoidosis
Authors: David A. Hashemi, Misha Rosenbach
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
”Keratinocyte growth factor­induced proliferation of rat airway epithelium is restricted to Clara cells<i>in vivo</i>”. H. Fehrenbach, A. Fehrenbach, T. Pan, M. Kasper, R.J. Mason.<i>Eur Respir J</i>2002; 20: 1185–1197.: 1
Journal: European Respiratory Journal (2003)
Multi-Institutional Analysis of Robotic Partial Nephrectomy for Hilar Versus Nonhilar Lesions in 446 Consecutive Cases
Authors: Lori M. Dulabon, Jihad H. Kaouk, Georges-Pascal Haber, Douglas S. Berkman, Craig G. Rogers, Firas Petros, Sam B. Bhayani, Michael D. Stifelman
Journal: European Urology (2010)
Iatrogenic depression. A case of misguided paternalism
Authors: J. S. Tamerin
Journal: JAMA (1972)

A case of reactive depression following recovery from life-threatening illness emphasizes the importance of understanding individual psychodynamics and corporate dynamics in the management of these patients when they return to work. The case illustrates the reasons why any tendency by the physician to protect such patients must be tempered by an awareness that (1) for certain individuals the protected job may be, paradoxically, the most stressful; and (2) corporations may interpret a physician's recommendation of a less-pressured job for his patient as evidence of permanent disability.
FATIGUE AND RESISTANCE TO DISEASE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal