tbuckley/cabot-search huggingface dataset:
Exaggerated risk of vitamin B12 deficiency after HCV eradication with direct-acting antivirals
Authors: Diego Casas Deza, Vanesa Bernal Monterde, Eva Fernandez Bonilla, Silvia Espina, Marta Fernández Esgueva, Ana Martinez-Sapiña, Javier Fuentes, Jose M Arbones Mainar
Journal: Journal of Hepatology (2020)
Asthma in Children
Authors: G L Larsen
Journal: New England Journal of Medicine (1992)

Despite advances in the understanding of asthma, there is still a high rate of morbidity and mortality from this disease in children. Although many factors are involved, a persistent concern is that the overuse of beta-agonists combined with the underuse of antiinflammatory medications leads to increased mortality. The demonstration that airway inflammation is present in mild asthma and the observations that inflammatory stimuli increase airway responsiveness have led to the use of antiinflammatory agents at earlier stages of disease. However, the medications with antiinflammatory activity that are currently available are not effective for all patients. The problems posed by chronic severe asthma in a child despite appropriate use of corticosteroids suggest that our current concepts are overly simplistic. Therefore, health care workers dealing with this disease must maintain an open mind about what constitutes optimal therapy.
Fourth Summer School in Methods of Immunologic Research and Diagnosis
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Fourth Summer School in Methods of Immunologic Research and Diagnosis Get access JNCI: Journal of the National Cancer Institute, Volume 53, Issue 4, October 1974, Page 1189, https://doi.org/10.1093/jnci/53.4.1189 Published: 01 October 1974
Cost containment and quality care
Authors: R. Carlen
Journal: JAMA (1988)

<h3>In Reply.</h3> —Dr Forman states that in our letter we did not specify the parameters of the microwave field to which our patient was exposed. We contacted the Air Force and were informed that this information is considered classified and not available to civilians. We were not aware that Forman and colleagues<sup>1</sup>as well as Williams and Webb<sup>2</sup>had previously described cases similar to ours; we regret this omission. The psychological symptoms that occurred in their patients as well as in our patient were attributed to posttraumatic stress disorder. There is evidence that radar technicians who suffered behavioral changes following exposure to 1 to 10 GHz of radiation demonstrated abnormal band patterns in cerebrospinal fluid protein electrophoresis.<sup>3</sup>It is unknown if this abnormal pattern could account for the symptoms observed. Dr Forman also points out that a previously reported case has been discredited.<sup>4,5</sup>The aforementioned case
Editorial: Radiology in diabetes.
Journal: BMJ (1975)

incisions, an extra reason for resisting further laparotomy as long as possible in such cases.Patients treated expectantly must be watched carefully in the first few days to ensure that complications do not occur.Surgical treatment is indicated for obstruction or perforation4 of the intestinal tract; for toxaemia from absorption of chemi- cal constituents of the object; or if the length, size, or shape of the object suggests that it will not pass.Radiographs may not show the object, and it must be borne in mind that lead is now used infrequently in the manufacture of toys and glass, and so these may no longer be radio-opaque.One recent development is the use of fibre-endoscopy to remove objects from the stomach as well as the oesophagus. 5
Chronic Bronchitis
Authors: H. G. Langdale-Smith
Journal: BMJ (1954)

Laboratory adapted and vaccine strains of measles virus (MV) induced type I IFN in infected cells. The wild-type strains in contrast induced it to a far lesser extent. We have investigated the mechanism for this differential type I IFN induction in monocyte-derived dendritic cells infected with representative MV strains. Laboratory adapted strains Nagahata and Edmonston infected monocyte-derived dendritic cells and activated IRF-3 followed by IFN-β production, while wild-type MS failed to activate IRF-3. The viral IRF-3 activation is induced within 2 h, an early response occurring before protein synthesis. Receptor usage of CD46 or CD150 and nucleocapsid (N) protein variations barely affected the strain-to-strain difference in IFN-inducing abilities. Strikingly, most of the IFN-inducing strains possessed defective interference (DI) RNAs of varying sizes. In addition, an artificially produced DI RNA consisting of stem (the leader and trailer of MV) and loop (the GFP sequence) exhibited potential IFN-inducing ability. In this case, however, cytoplasmic introduction was needed for DI RNA to induce type I IFN in target cells. By gene-silencing analysis, DI RNA activated the RIG-I/MDA5-mitochondria antiviral signaling pathway, but not the TLR3-TICAM-1 pathway. DI RNA-containing strains induced IFN-β mRNA within 2 h while the same recombinant strains with no DI RNA required &gt;12 h postinfection to attain similar levels of IFN-β mRNA. Thus, the stem-loop structure, rather than full genome replication or specific internal sequences of the MV genome, is required for an early phase of type I IFN induction by MV in host cells.
Ingestion of Pseudoephedrine
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lehrbuch der Perkussion und Auskultation. Mit Einschluss der Ergänzenden Untersuchungsverfahren der Inspektion, Palpation und der Instrumentellen Methoden.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electromyography
Authors: Donald M. Posner
Journal: JAMA (1974)

<h3>To the Editor.—</h3> I would deny that the majority of neurologists are interested in or able to perform electromyography. Certainly there are neurologists who have no interest and perhaps have no competence in electrodiagnosis, but Dr. Ames's experience must be different from mine. I will readily concede that, with a few exceptions, none of the electrodiagnostic studies can be, or should be, considered diagnostic. Excluding these exceptions, they are merely laboratory studies like any other laboratory study, and the information obtained from them must be correlated with other clinical information available to the practitioner.
Rheumatology
Authors: George E. Ehrlich
Journal: JAMA (1979)

Four principals occupied center stage in rheumatology during 1978: (1) HLA genetic markers, (2) various new as well as old drugs, (3) the genesis of osteoarthritis, and (4) perhaps the most enigmatic of them all, mixed connective tissue disease. <h3>Genetic Markers</h3> The HLA system of antigens continues to be implicated in the development of some of the rheumatic diseases, even if the guilt is still primarily by association. The best established relationship remains that between the HLA-B27 antigen and ankylosing spondylitis. When spondylitic changes are associated with either acute anterior uveitis or Reiter's syndrome, this strong association remains. However, the distribution of HLA-B27 among persons with nonspecific urethritis is similar to that among healthy control subjects, and, therefore, it is important that the HLA-B27 antigen be related to the joint involvement and not to the urethritis.<sup>1</sup>The frequency of the association of the HLA antigen with the rheumatic diseases
GADOLIN: Primary results from a phase III study of obinutuzumab plus bendamustine compared with bendamustine alone in patients with rituximab-refractory indolent non-Hodgkin lymphoma.
Authors: Laurie Helen Sehn, Neil Sun Chua, Jiri Mayer, Gregory Scott Dueck, Marek Trněný, Kamal Bouabdallah, Nathan Hale Fowler, Vincent Delwail, Oliver W. Press, Gilles A. Salles, John G. Gribben, Anne Lennard, Pieternella J. Lugtenburg, Natalie Franklin, Elisabeth Wassner Fritsch, Guenter Fingerle-Rowson, Bruce D. Cheson
Journal: Journal of Clinical Oncology (2015)

LBA8502 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Saturday, May 30, 2015, and in the Annual Meeting Proceedings online supplement to the June 20, 2015, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Monday edition of ASCO Daily News.
Clinicians’ Expectations of the Benefits and Harms of Treatments, Screening, and Tests
Authors: Tammy C. Hoffmann, Chris Del Mar
Journal: JAMA Internal Medicine (2017)

Inaccurate clinician expectations of the benefits and harms of interventions can profoundly influence decision making and may be contributing to increasing intervention overuse.To systematically review all studies that have quantitatively assessed clinicians' expectations of the benefits and/or harms of any treatment, test, or screening test.A comprehensive search strategy of 4 databases (MEDLINE, EMBASE, Cumulative Index of Nursing and Allied Health Literature, and PsycINFO) from the start years to March 17-20, 2015, with no language or study type restriction, was performed. Searches were also conducted on cited references of the included studies, and experts and study authors were contacted. Two researchers independently evaluated methodologic quality and extracted participants' estimates of benefit and harms and authors' contemporaneous estimates.Of the 8166 records screened, 48 articles (13 011 clinicians) were eligible. Twenty studies focused on treatment, 20 on medical imaging, and 8 on screening. Of the 48 studies, 30 (67%) assessed only harm expectations, 9 (20%) evaluated only benefit expectations, and 6 (13%) assessed both benefit and harm expectations. Among the studies comparing benefit expectations with a correct answer (total of 28 outcomes), most participants provided correct estimation for only 3 outcomes (11%). Of the studies comparing expectations of harm with a correct answer (total of 69 outcomes), a majority of participants correctly estimated harm for 9 outcomes (13%). Where overestimation or underestimation data were provided, most participants overestimated benefit for 7 (32%) and underestimated benefit for 2 (9%) of the 22 outcomes, and underestimated harm for 20 (34%) and overestimated harm for 3 (5%) of the 58 outcomes.Clinicians rarely had accurate expectations of benefits or harms, with inaccuracies in both directions. However, clinicians more often underestimated rather than overestimated harms and overestimated rather than underestimated benefits. Inaccurate perceptions about the benefits and harms of interventions are likely to result in suboptimal clinical management choices.
Medical specialization
Authors: G. G. Liddle
Journal: JAMA (1968)

<h3>To the Editor:</h3> Beer drinking has been condemned on several counts in the past. Obesity and nutritional cirrhosis have long been attributed to excessive beer consumption, and more recently "beer drinker's heart" has been described. We would like to chronicle a new and unusual complication associated with beer. <h3>Report of a Case:—</h3> A 29-year-old Negro woman entered City Hospital Emergency Room with a complaint of pain and swelling of the left ring finger. The patient had been involved in a beer drinking bout with a number of heavy imbibers. After consuming several cans of beer, she apparently idly slipped several of the rings of the pop-top beer can openers over the left ring finger after removing the metal flange which seals the opening in the can. The party continued until late into the next day and on awakening 24 hours later the patient noted pain and swelling in the left
Cytogenetic Monitoring of Human Populations at Risk in Egypt: Role of Cytogenetic Data in Cancer Risk Assessment
Authors: Wagida A. Anwar
Journal: Environmental Health Perspectives (1991)

Somatic mutation plays a critical role in carcinogenesis. Numerous environmental agents can increase the probability that somatic mutation will occur. The use of genotoxicity testing is essential for assessing potential human toxicity so that hazards can be prevented. Cytogenetic monitoring of human populations exposed to chemicals has proved to be a useful tool for detecting the chemical mutagenic effects. Cytogenetic analyses of human chromosomes in peripheral lymphocytes allows direct detection of mutation in somatic cells. Different methods can be used for chromosomal analysis (conventional chromosomal analysis, sister chromatid exchange, micronucleus frequency detection). Micronucleus frequency can be detected either in peripheral blood lymphocytes or in exfoliated cells. Different examples of human population studies are presented. Several problems that are found in biomonitoring studies are discussed. These studies should help us learn about individual exposure assessment and biologically relevant doses, leading to quantitative assessment of human cancer risks.
Abstract 219: Histidine Substituted Cardiac Troponin I (a164h) Improves Survival And Protects Cardiac Contractility During Acute Hypoxia In The Aged Murine Heart.
Authors: Nathan Palpant, Sharlene Day, Kimber Converso, Joseph Metzger
Journal: Circulation (2007)

Contractile dysfunction associated with ischemia is a significant cause of morbidity and mortality particularly in the elderly. Strategies designed to protect the aged heart from ischemia-mediated pump failure are needed. We have generated transgenic (Tg) mice expressing a modified form of adult cardiac troponin I, the Ca ++ -activated molecular switch of the myofilament. Consonant with the fetal isoform, this transgene encodes a histidine substitution (A164H) in the critical switch domain of TnI thus increasing myofilament calcium sensitivity in a pH-dependent manner. We hypothesized that aged mice (24 months), intrinsically susceptible to myocardial dysfunction, would retain improved cardiac contractility at baseline and during an acute hypoxic challenge by means of myofilament-mediated calcium sensitization. Methods/Results: At baseline, by echocardiography, Tg hearts had increased systolic function, with a 26% higher mean ejection fraction compared to nontransgenic (Ntg) mice: 75 ± 3% [Tg: n = 13] vs. 63 ± 4% [Ntg: n = 12], P &lt; 0.05, with no differences in diastolic function between the groups. To study the effects of acute hypoxia on cardiac hemodynamics mice underwent microconductance Millar catheterization while ventilated with 12% oxygen. Aged Tg mice had improved survival compared to Ntg mice: time to pump failure (65% of baseline peak systolic pressure) 11.59 ± 1.25 min. [Tg: n = 3] vs. 4.11 ± 1.90 min. [Ntg: n = 3], P &lt; 0.05. After four minutes of hypoxia, Tg mice had markedly improved cardiac contractility compared to Ntg mice with increased stroke volume (30.05 ± 4.49 uL [Tg] vs. 13.23 ± 3.21 uL [Ntg], P &lt; 0.05), end systolic pressure (106.09 ± 11.81 mmHg [Tg] vs. 64.49 ± 4.05 mmHg [Ntg], P &lt; 0.05) and rate of positive left ventricular pressure development (12958.66 ± 2544.68 mmHg/sec [Tg] vs. 5717.00 ± 745.67 mmHg/sec [Ntg], P = 0.05). Conclusion: An alteration in myofilament calcium sensitivity via a pH-responsive histidine button in cardiac troponin I augments baseline heart function in Tg mice over their lifetime. During acute hypoxia, cTnI A164H improves survival in aged mice by maintaining cardiac contractility, and thus holds promise for the design of gene therapeutics to treat pump failure associated with acute ischemic events in the elderly.
Are Patients With Psoriasis Susceptibleto the Classic Risk Factors for Actinic Keratoses?
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asymptomatic mediastinal mass in a 49-year-old man
Authors: M. A. Zaheer
Journal: JAMA (1979)

<h3>History</h3> An asymptomatic 49-year-old man was referred because of an abnormal chest roentgenogram. Findings from physical examination were normal. Chest roentgenograms, tomogram, and esophagogram are presented (Fig 1 through 4). <h3>Diagnosis</h3> Bronchogenic cyst. An oval hemogeneous shadow to the left of the upper posterior mediastinum was found on the chest roentgenogram. Fluoroscopy and barium study showed this mass to be paraesophageal.<sup>1</sup>It moved with swallowing. No intrinsic pulsations were seen. Differential diagnosis included enteric cyst, bronchogenic cyst, esophageal tumor (eg, leiomyoma), substernal thyroid, lymph node enlargement, and vascular lesion.<sup>2</sup> Radioactive iodine scan showed no uptake in the mass, and the thyroid gland appeared normal. Thoracic aortography was also normal. At surgery, a 5-cm diameter cyst was found loosely attached posteriorly to the esophageal wall. It contained mucoid material. Histological sections of the wall showed ciliated pseudostratified columnar epithelium and underlying hyaline cartilage. <h3>Comment</h3> Bronchogenic cysts are developmental in
"FATALITIES FROM LOCAL ANESTHETICS"
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Progress toward achieving the national 1990 objectives for injury prevention and control
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Naproxen (naprosyn) and gastrointestinal haemorrhage.
Authors: Consultant Discontent, C Maycock, J Whiteside, Hedley Berry, Jeffery Maccabe, Michael Brudenell, Colin Mckerron, R Catterall, A Mowat, Leonard Cotton, S Oram, R Crellin, David Pyke, J Dawson, C Stroud, Stephen Elkin, Thomas Maelor, Peter Feroze, David Watkins, D Jewitt, Harold Williams, Roger Ludman, A Williams, Kevin Macarthur
Journal: BMJ (1974)