tbuckley/cabot-search huggingface dataset:
Liver
Authors: P Masumom, 3dj Boon, R Jalan, H Gibson, M Lombard
Journal: Gut (1996)

Objectives: To determine (1) the contribution of angiotensin HI (AHl) to basal and sympathetically stimulated vascular tone, ad (2) the vamular sensitivity to AII, noradrenaline (NA) and the nitric oxide (NO) synthase inhibitor, L-NMMA, in patients with cirrhosis.Methods: Forearm blood flow (FBF) was measured using venous occlusion plethysmography in both arms on two separate randomised occasions in 7 patients with cirrhosis (Child C) and 7 healthy volunteers.The brachial artery of the non-dominant arm was cannulated and baseline infusion of 0.9% saline commenced.On one occasion, intra-arterial losartan (All type I receptor antagonist) was infused alone at doses of 30 and 90 pg/min for 30 min each.FBF was measured before and during application of lower body negative pressure (LBNP) of 15mmHg.Following 30 min of saline, NA was infused at 20, 60, 180 and 540 pmol/min for 6 min at each dose.On the other occasion, AII was infused at 1, 3, 10 and 30 pmol/min for 6 min at each dose, followed after 30 min of saline followed by 15 min of L-NMMA at 4 jmollmin.Results: Losartan at 30 and 90 ug/min caused no significant change in FBF in healthy volunteers but caused 23±6% and 27±5% increase in patients respectively (p<0.001).Reduction in FBF with LBNP was significantly lower in patients compared with healthy volunteers (9±5% versus 24±4%, p<0.001).AII and NA caused dose dependent vasoconstriction (p<0.001) with no significance between group differences.Moreover, there was no significance between group differences in the reduction in FBF (38±6%) caused by L-NMMA.Conclusions: Endogenous AII contributes to the basal vascular tone in cirrhosis but not in health volunteers.The NO production and vascular reactivity to AII and NA are normal, but the sympathetic nervous system mediated reflex vasoconstriction is impaired.This indicates that these patients have impaired central, but stimulated humoral, r ation of vascular tone without alteration in sensitivity to these vasoactive mediators.Thus, it is suggested that the previously reported impairment of systemic responses to AII and NA is a consequence of deranged central regulatory mechanisms rather than a reduction in the vascular sensitivity to these mediators.Patients with PBC have central but no peripheral fatigue
Hepatology Highlights
Authors: Jean‐François Dufour
Journal: Hepatology (2016)

Admittedly a High Readmission RatePatients with cirrhosis who have been hospitalized tend to be rehospitalized in the following weeks.Understanding the reasons for these repetitive hospitalizations may decrease their burden on the health system.Bajaj et al., on behalf of the North American Consortium for the Study of End Stage Liver Disease, enrolled 1,353 patients with cirrhosis who were hospitalized at 14 centers in a prospective study.The majority (53%) were readmitted within 3 months.At entry and at discharge of the initial hospitalization, the researchers looked at parameters that could predict readmission.Severity of cirrhosis, presence of diabetes, and nosocomial infection were associated with readmission.However, in one third of patients, it was not possible to predict readmission.Socioeconomic aspects are likely to also play a role in rehospitalization.(HEPA-
Treatment with thyroid hormone
Authors: A. R. Gaby
Journal: JAMA (1989)

<h3>To the Editor.—</h3> In reference to the editorial by Dr Cooper,<sup>1</sup>practitioners who continue to use thyroid extract despite criticism from their colleagues do so for a good reason: it sometimes works better than other thyroid preparations. I frequently see patients receiving long-term levothyroxine sodium therapy who, despite supposedly appropriate treatment, still complain of fatigue, depression, cold extremities, dry skin, or other symptoms. After changing to an equivalent (or sometimes slightly less than equivalent) dosage of desiccated thyroid, these symptoms improve considerably. One might speculate that the therapeutic advantage of thyroid extract is due to diiodotyrosine. As much as 38% of the iodine present in the thyroid gland is in the form of this compound, and diiodotyrosine is found naturally in the blood. In one study,<sup>2</sup>diiodotyrosine was effective in the treatment of thyrotoxicosis, suggesting that this compound may somehow modulate the effect of thyroid hormones. We should
PLoS Medicine Issue Image | Vol. 8(1) January 2011
Journal: PLoS Medicine (2011)

On 25 January 2011, World Health Organization (WHO) and PLoS Medicine announce a call for papers to inform the World Health Report 2012, which will be a groundbreaking report focusing for the first time on research for better health. Entitled "No Health Without Research," the report will be published by WHO in May 2012. In advance of this landmark publication, WHO and PLoS Medicine jointly invite submission of papers to PLoS Medicine related to strengthening national health research systems (see the Editorial [e1001008]). Research papers, case studies, and non-research papers will all be considered. A joint WHO/PLoS panel will select papers for inclusion in an ongoing special WHO/PLoS Collection leading up to the report's publication. The impetus behind the report is the need to emphasize the importance of research evidence in health care decision-making, and particularly so in the areas of health policy and health systems; the collection will showcase examples of the best research underpinning practice and policy worldwide. Image Credit: David Bleasdale , flickr.com
A TRACTION SPLINT FOR FRACTURES OF THE HUMERUS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CRUDE COCAIN IS NOT A MEDICINAL PREPARATION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypertension as an Expression of the Lack of the Well-Balanced Life
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diffuse Combined Degeneration of the Spinal Cord
Journal: New England Journal of Medicine (1928)

met, believe me, gentlemen, by any ingenuity and reasoning, by any manifold duty and resent- ment of counsel.No ingenuity of convincing or manifold reasoning will permit you to meet this issue that you have got to meet- Prepare yourselves by assuring yourselves that nothing in suggestion to your brain or mind has escaped this investigation.Then the case will be presented in court beyond a question of dispute of what thc autopsy did reveal, leaving only legitimate elimination of thc inferences that can be drawn from them.This is the responsibility of the medical exam- iner briefly stated by one who is interested as you are in seeing to it that the beneficent pur- poses of our law, framed in our statutes, find its realization in the courts of justice, which are the places where human injuries manifest themselves, and the effort, to make our human system of law follow along so far as we are able, to preserve them, and transform them to the divine law, under which wc live and must ultimately go.
Malaria in Britain: 1982.
Journal: BMJ (1983)

A total of 1471 cases of malaria were imported to Britain in 1982, as ascertained by notifications and reports on blood films ex- amined by the Public Health Laboratory Service Malaria Re- ference Laboratory.The total follows a continuing downward trend which began in 1980, but the figures give little reason for complacency because cases of the most severe form of malaria, Plasmodiumfalciparum, increased in number in 1982 (see fig), the overall fall being explained by the decline in P vivax infections.Most of the increase in P falciparum malaria was in patients re- turning from east and central Africa.
The Definition of Alcoholism
Authors: Dennis Donovan
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The Joint Committee of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine<sup>1</sup>purport to offer a definition of alcoholism that is scientifically valid and clinically useful. Alcoholism is described as a "primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by... distortions in thinking, most notably denial." Denial is construed as "a range of psychologic maneuvers that decrease awareness of the fact that alcohol use is the cause of a person's problems rather than a solution to those problems" that "becomes an integral part of the disease and is nearly always a major obstacle to recovery." While the committee has done much to elucidate important aspects of alcoholism and to encourage consistent application of the term, its identification of denial as a cardinal feature
Recommendations for epidemiological studies on COPD
Authors: Per Sigvald Bakke, Eva Rönmark, Tomas Mikal Eagan, Francesco Pistelli, Isabella Annesi-Maesano, Marek Maly, Mari Meren, Jan Zielinski, Giovanni Viegi, Bo Lundbäck
Journal: European Respiratory Journal (2012)

We thank P.H. Quanjer and co-workers for their valuable comments to our paper [1].Chronic obstructive lung disease (COPD) is a syndrome and we welcome a debate on how to define it in an epidemiological setting.
Group Work with the Aged
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Role of the Thomsen-Friedenreich Antigen As a Tumor-Associated Molecule
Authors: Wolfgang Dippold, Andrea Steinborn, Karl-Hermann Meyer zum Buschenfelde
Journal: Environmental Health Perspectives (1990)

The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c mice with MCF-7 breast tumor cells together with synthetic Gal-GalNAc linked to a BSA carrier. One monoclonal antibody (82-A6) was established which recognizes the Thomsen-Friedenreich antigen according to the biochemical and serological analysis presented here. In contrast to the studies performed in the past, immunohistochemical results using this antibody 82-A6 did not exhibit a reactivity clearly restricted to tumors. Preliminary biochemical analysis revealed that the T-determinant is detectable in the high-molecular weight range (about 1000 kD), suggesting that the Gal-GalNAc epitope is found on mucinlike glycoproteins. Tumor restriction of Thomsen-Friedenreich antigen may therefore be determined either by the protein backbone or by the beta-glycosidic linkage of the carbohydrate structure to the protein.
Lead Analysis of the House Dust: A Method for the Detection of Another Source of Lead Exposure in Inner City Children
Authors: Jaroslav J. Vostal, Ellen Taves, James W. Sayre, Evan Charney
Journal: Environmental Health Perspectives (1974)

A method has been developed to test the hypothesis that lead-containing house dust is responsible for the elevated levels of lead in blood of inner city children. Dust analyses of smears from the floors, walls, and windowsills in low-income inner city dwellings have shown a median concentration of lead five times as high in suburban homes. It is suggested that lead-containing dust may be one of the most important environmental sources of increased lead exposure in this specific population group.
Response
Authors: N. Potischman, C. A. Swanson, P. Sitteri, R. N. Hoover
Journal: JNCI Journal of the National Cancer Institute (1997)

ovulation, is probably associated with reduced production of both estradiol and progesterone in the second half of the menstrual cycle (4).However, in contrast to the unequivocal relationship of BMI with SHBG and with postmenopausal estradiol concentration, any association between BMI and estradiol concentration in premenopausal women with regular menstrual cycles is more subtle.
Leads from the MMWR. Update: acquired immunodeficiency syndrome--Europe
Journal: JAMA (1985)

As of 30 September 1985, 1,573 cases of acquired immunodeficiency syndrome (AIDS) had been reported to the World Health Organization (WHO) European Collaborating Centre on AIDS. There was an average increase of 27 cases per week, and 792 of the 1,573 patients were reported to have died. In 12 of 16 countries, homosexual males accounted for 60-100% of the total number of cases, but there was also a significant increase in the numbers of intravenous drug abusers with AIDS. Systematic screening of blood donors for antibodies to the AIDS associated virus became effective in 16 of the 21 reporting countries by November 1985, and measures to exclude donors at risk had been taken in all but three of the countries.
Book Review Bone Growth in Health and Disease . The Biological Principles Underlying the Clinical, Radiological, and Histological Diagnosis of Perversions of Growth and Disease in the Skeleton. By H. A. Harris, D.Sc.Lond., M.B., B.S. (Lond.), B.Sc. (Wales), M.R.C.S., M.R.C.P., Professor of Clinical Anatomy, University College and University College Hospital, London, Etc. Oxford University Press. London: Humphrey Milford. 1933. 248 Pages.
Journal: New England Journal of Medicine (1934)
Germinomas and Teratoid Siphon Anomalies in Softshell Clams, Mya arenaria, Environmentally Exposed to Herbicides
Authors: George R. Gardner, Paul P. Yevich, John Hurst, Peter Thayer, Sandra Benyi, John C. Harshbarger, Richard J. Pruell
Journal: Environmental Health Perspectives (1991)

Seminomas and dysgerminoma are epizootic in softshell clams, Mya arenaria, from threeMaine estuaries contaminated with herbicides.Tbe first epizootic was dismred in 22% ofclams coliected as Searsport near Long Cove Brook and three culverts that conveyed heating oil andjet fuel spiled from a tank farm in 1971.Data from subsequent epizootilogca studies and a series oflong-term experimental exposures ofsoftshel clams to no. 2 fuel oil, JP4, and JP-5 jet fuel atthe U.S. EPA, Environmental Research Laboratory in Narragansett, Rhode Island, and in the field did not support an etiology by these petroleum products.In the two recent epizootics reported here, the genminomas have been observed in 3% ofthe softshell clams collected from Roque Bluffs near Machiasport and from 35% of softshell clams collected from Dennysville.Mya coilected at Dennysvilie had perirdial mesotheliomas and teratoid siphon anomalies in addition to gonadal neoplasms.Esuaries at Dennysville had been contaminatedby herbicides inn 1979 accidental spray overdrift during aerial application ofTordon 101 to adjacent forests.Further investigation determined widespread use of the herbicides Tordon 101, 2kAD, 2,4,5-T, and other agrochemicals in an extensive forestry and blueberry industry in both the Roque Bluffs and the Dennys- ville areas.Herbicide applications at Searsport were confirmed for railroad property bordering Long Cove estuary and for Long Cove Brook adjacent to the estuary where a highway departnent reportedly cleans its spray equipment.Herbicide contamination is the only common denominator identified at aUl three sites where Mya have been found with gonadal neo- plansm The suggested iation of herbicides with gonadal neopam indams is strengthened by the inresd incidence of seminomas observed in military working dogs exposed to defoliating herbicides in Vietnam between 1967 and1972.
Sorafenib treatment in recurrent hepatocellular carcinoma post liver transplantation.
Authors: Nazanin Fallah-Rad, Yanshuo Cao, Gonzalo Sapisochin, Neesha C. Dhani, Jennifer J. Knox, David Grant, Raymond Woo-Jun Jang, Paul David Greig, Leslie Lilly, Eric Xueyu Chen
Journal: Journal of Clinical Oncology (2017)

e15613 Background: Liver transplantation (LT) is a potentially curative treatment for patients (pts) with selective hepatocellular carcinoma (HCC). HCC recurrence post LT is estimated to be 15-20%. Data on systemic therapy post-recurrence is scarce and limited case series suggest that sorafenib (SOR) may have benefit in this population. We reviewed a single center experience with SOR in recurrent HCC post LT Methods: A retrospective review was conducted on pts with recurrent HCC post LT at University Health Network (UHN) who were treated with SOR. Pt characteristics were collected including age, gender, comorbidities, background liver disease, type of LT, and time to recurrence after LT. Treatment information collected included: initial SOR dose (and adjustments), adverse events (AEs), duration of treatment and survival. Results: Between 2006 and 2016, 24 pts were identified. The average age was 60 years (range: 18-72), most pts were male (20/4), living/cadaveric transplant: 11/13. HCC etiology included hepatitis B (10), alcohol (4), NASH (3), hepatitis C (2), hemochromatosis (2), Budd-Chiari (2) and unknown (1). The average time to recurrence of HCC was 16.08 (range: 1.5-60) months post OLT. There was a bimodal time to recurrence with a median of 6 months. SOR starting doses were 200 mg BID in 18 pts, 300 mg BID in 1 and 400 mg BID in 4. 14 pts required dose adjustment due to AEs, mainly relating to fatigue and palmar-plantar syndrome. The median time on treatment was 2.5 (range: 0.25-37) months. The average time to progression on SOR and/or discontinuation due to AEs was 4.30 (+/- 7.2) months. Conclusions: SOR is reasonably tolerated in pts with recurrent HCC post LT, with expected AE profiles. In this small case series, the median time on SOR was short and estimated time to progression was shorter than that in non-transplant HCC population. Overall, SOR has limited activity in this population, but selected pts may derive extended benefit. Better understanding of responders and investigations of other therapies are needed for this population.
Aerztliche Forschung, Munich
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal