tbuckley/cabot-search huggingface dataset:
Letter: Confidentiality.
Authors: C Wilson, H Loh
Journal: BMJ (1973)

they have cancer may "go to pieces," by which is usually meant that they weep in the presence of their doctor, is to do with the doctor's difficulty in coping with his patient's grief.Because patients have reason not to believe their doctors, there are many who have difficulty in believing their doctor when he truthfully denies the presence of serious disease.-Iam, etc., EMANUEL LEWISLondon N.W.3Surgery on Day Patients SIR,-Mr. A. B. Cassie raises some impor- tant issues about outpatient surgery (8 September, p. 542).We have recently reviewed the results in 300 patients undergo ng major out- patient operations in this hospital.An account of the series will shortly be published, but in the light of Mr. Cassie's letter some preliminary observations seem warranted.Operations for which outpatient surgery is appropriate, in selected patients, can in- dlude inguinal or femoral herniorrhaphy, stripping and multiple ligatiens of varicose veins, and other p-rocedures of eouivalent severity.We find it a highly satisfactory system with a complication rate which com- pares favourably with inpatient surgery.The above statements require some very careful qualifications.The essential ingredients for a satisfactorv outpatient surgery system are as follows.A consultant surgeon must be interested in the method and pre- pared to supervise the hospital part closely.
BCG and Cancer: Reply
Authors: George W. Comstock, M.D.
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article BCG and Cancer: Reply Get access George W. Comstock, M.D. George W. Comstock, M.D. Professor of Epidemiology School of Hygiene and Public Health The Johns Hopkins UniversityBaltimore, Maryland 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 67, Issue 5, November 1981, Page 991, https://doi.org/10.1093/jnci/67.5.991-a Published: 01 November 1981
Ventricular tachycardia during intravenous urography. Report of two cases
Authors: R. Stadalnik
Journal: JAMA (1974)

THE incidence of reactions to intravenously given contrast agents approximates 1 in 2,000,<sup>1</sup>and mortality from the use of these agents is considerably lower, 8.6 per million to 19 per million. Death, which is usually sudden, occurs more often in older patients, frequently in association with cardiac arrest.<sup>1</sup>Electrocardiographic changes comprising ectopic atrial, junctional, or ventricular beats, bundle-branch block, and ischemic ST-T segmental changes are not uncommon.<sup>2</sup>However, the onset of ventricular tachycardia (VT) has not been reported previously, to our knowledge. During electrocardiographic monitoring in more than 100 patients undergoing intravenous urography at the Sacramento Medical Center, 2 of the more than 80 patients receiving iothalamate sodium 66.8% (Conray 400) showed an abrupt onset of VT, one, without premonitory ectopic ventricular beats. Both patients reverted to sinus rhythm after an intravenous injection of 100 mg of lidocaine (Xylocaine) was given to each. <h3>Report of Cases</h3><h3>Case</h3>
Re: Hojjat Ahmadzadehfar, Markus Essler. Prostate-specific Membrane Antigen Imaging: A Game Changer in Prostate Cancer Diagnosis and Therapy Planning. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2019.02.028
Authors: Bingzhi Wang, Huan Deng, Lan Cao
Journal: European Urology (2019)
Sudden and unexpected natural death in childhood and adolescence
Authors: D. R. Neuspiel
Journal: JAMA (1985)

The descriptive epidemiology of sudden nontraumatic death from persons aged 1 to 21 years was studied in a defined population. In nine years, the 207 deaths in this group (4.6/100,000 population/per year) comprised 22% of nontraumatic mortality. Age-specific rates were highest between 1 and 4 years (mainly infections and undetermined causes) and 14 and 21 years (mainly cardiovascular, epilepsy, intracranial hemorrhage, and asthma). Nonwhite rates were higher than whites, and white males had higher rates than white females. Referral for medicolegal evaluation was inconsistent. Only 18% died at university hospitals. Infections included lower respiratory tract and septic shock. The main cardiac diagnosis was myocarditis. Most epilepsy deaths were unwitnessed and had absent or low anticonvulsant levels. Eighty-five cases had a known associated chronic illness and 111 reported prodromal symptoms. Prevention of these events requires improved identification and management of antecedent conditions. (<i>JAMA</i>1985;254:1321-1325)
La perméabilité et les obturations tubaires: Stérilité—Infections salpingiennes. Chirurgie tubaire.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Process improvement in breast cancer care: Is mammography volume associated with a greater need for process improvement?
Authors: Danielle Dupuy, Christine B. Weldon, Julia R. Trosman, Elizabeth A. Marcus, Betty Roggenkamp, Julian C. Schink, David Ansell, Anne Marie Murphy
Journal: Journal of Clinical Oncology (2013)

6609 Background: Chicago Black women are 62% more likely to die from breast cancer than White women. Previous data from 39 Chicago hospitals suggested significant variation in mammography quality (Chicago Breast Cancer Quality Consortium, 2010). We developed process improvement recommendations for sites that participated in our care process assessment (Weldon CB, et al, ASCO-Abstract-6120-2012). This study was funded through a generous grant from the Susan G. Komen for the Cure Foundation. We compared improvement needs between high and low patient volume institutions. Methods: Using Deming’s PDCA cycle for continuous improvement, we created care process improvement recommendations for 25 Chicago institutions with the patient base averaging more than 50% minority patients (20 community, 3 academic and 2 public hospitals). Low mammography volume (&lt; 5000 mammograms/ year) was reported by 12 of the 25 sites. Recommendations are based on analysis across sites, literature, and input from institution staff. Thematic and statistical analyses were performed using simple frequencies and Fisher's exact test. Results: Improvement recommendations are classified into nine areas, see table. We found that 100% (12/12) of low mammography volume institutions have specific improvement needs in 6 or more process improvement areas, as compared to 23% (3/13) of the high mammography volume institutions (pvalue &gt; 0.0001). Conclusions: Lower volume mammography sites have a larger need for breast cancer care process improvements. [Table: see text]
Diseases of the Urinary Tract in Children.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vein Grafts in the Venous System: Experimental Evaluation of Autogenous Veins Used as Bypass Implants
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thanksgiving, 1970 Style
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ten Steps to Advance Biomarker Testing
Journal: Cancer Discovery (2016)

Matching patients with the most effective therapies for their cancer can require testing tumors for genetic mutations or expression of the proteins that certain drugs target. However, tests for these biomarkers can vary in quality, and evidence of their clinical value may be lacking. A recently issued report from the Institute of Medicine outlines 10 interrelated recommendations to resolve these and other concerns about biomarker testing-and more fully implement personalized medicine.
LIPEMIA RETINALIS
Authors: HORACE GRAY
Journal: JAMA (1923)

It seems time to draw to the attention of medical men a subject which has been discussed usually by ophthalmologists, and often too only in relatively inaccessible society transactions. We have been able to find only twenty-six cases reported so far. <h3>REPORT OF A TWENTY-SEVENTH CASE</h3> Mrs. R. was 50 years and 9 months old when the onset of diabetes was announced by blurred vision; this, with subsequent urinary incontinence, caused examination and diagnosis a month later. Almost exactly a year afterward, she came under Dr. Joslin's care. The twenty-four-hour urine then contained 85 gm. of sugar, and diacetic acid was + + +; the alveolar carbon dioxid was 31 mm.; the blood before breakfast showed creamy plasma, with 5.12 per cent, fat (Bloor) and sugar 0.31 per cent.; the net weight was 30 kg., 46 per cent, below her maximum of 113 pounds (51 kg.) three months before the onset of symptoms.
Manuscripts Approved for JNCI, January 15 to February 15, 1962
Journal: JNCI Journal of the National Cancer Institute (1962)

Manuscripts Approved for JNCI, January 15 to February 15, 1962 JNCI: Journal of the National Cancer Institute, Volume 28, Issue 3, March 1962, Pages 747–748, https://doi.org/10.1093/jnci/28.3.747-a Published: 01 March 1962
Atrial Natriuretic Peptide: A New Factor in Hormonal Control of Blood Pressure and Electrolyte Homeostasis
Authors: S. Atlas
Journal: Annual Review of Medicine (1986)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Introduction: Utilization of Higher Plant Systems as Monitors of Environmental Mutagens
Authors: Frederick J. de Serres
Journal: Environmental Health Perspectives (1978)

Research over the past 10 years has clearly demonstrated the presence of mutagens among the numerous man-made and naturally occurring chemicals in our environment. These mutagens occur in all classes of chemicals, including foods, drugs, cosmetics, pesticides, household and industrial chemicals as well as in pollutants of both air and water. More recently, a high correlation has been found between carcinogenic and mutagenic activity; at least 90–95% of chemical carcinogens are mutagens. There is a widespread expectation that the discovery of mutagenic activity in chemical screening programs may alert us not only to mutagenic potential in man, but carcinogenic potential as well. The types of genetic damage which can be produced are numerous and the specificity of chemical mutagens makes it possible for one type of effect to be produced predominantly or exclusively. Thus, any screening program must consist of a battery of tests capable of detecting nondisjunction, chromosome aberrations, gene mutations (point mutations as well as interstitial deletion), in addition to more subtle effects of DNA repair. In addition, since innocuous chemicals can be converted by mammalian metabolism to potent mutagens and carcinogens, these metabolites must be evaluated as well as the parent compounds. Chemicals such as air pollutants present particular problems for mutagenicity testing using conventional microbial assays. Some of these problems can be overcome by using various higher plant systems. The general utility of these systems needs to be evaluated in terms of the types of genetic damage which can be detected, relative sensitivity, and general utility for use in mutagen screening and monitoring.
Mechanisms of Action of Okadaic Acid Class Tumor Promoters on Mouse Skin
Authors: Hirota Fujiki, Masami Suganuma, Seiji Yoshizawa, Shinji Nishiwaki, Boonsong Winyar, Takashi Sugimura
Journal: Environmental Health Perspectives (1991)

Okadaic acid, dinophysistoxin-1 (35-methylokadaic acid), and calyculin A are the okadaic acid class of non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters, which do not bind to the phorbol ester receptors in cell membranes or activate protein kinase C in vitro. They have potent tumor-promoting activities on mouse skin, as strong as TPA-type tumor promoters, such as TPA, teleocidin, and aplysiatoxin. DNA samples isolated from tumors induced by dimethylbenz[alpha]anthracene and each of the okadaic acid class tumor promoters had the same mutation at the second nucleotide of codon 61 (CAA to CTA) in the c-H-ras gene. Okadaic acid receptors, protein phosphatases 1 and 2A, are present in the particulate as well as cytosolic fractions of various mouse tissues. The apparent "activation" of protein kinases by the okadaic acid class tumor promoters, after their incubation with 32P-ATP, protein kinases, and protein phosphatases, was observed. This activation was caused by inhibition of protein phosphatases 1 and 2A by the okadaic acid class tumor promoters. Treatment of primary human fibroblasts and human keratinocytes with the okadaic acid class tumor promoters induced the hyperphosphorylation of a 60-kDa protein in nuclear and cytosolic fractions, due to the inhibition of protein phosphatases. The 60-kDa protein is a proteolytic fragment of nucleolin, a major nonhistone protein and is designated as "N-60." The mechanisms of action of the okadaic acid class tumor promoters are discussed with emphasis on the inhibition of protein phosphatase activity.
Interim Guidelines for the Evaluation of Infants Born to Mothers Infected With West Nile Virus During Pregnancy
Journal: JAMA (2004)

West Nile virus (WNV) is a single-stranded RNA flavivirus with antigenic similarities to Japanese encephalitis and St. Louis encephalitis viruses. It is transmitted to humans primarily through the bites of infected mosquitoes. Flavivirus infection during pregnancy has been associated rarely with both spontaneous abortion and neonatal illness but has not been known to cause birth defects in humans. During 2002, a total of 4,156 cases of WNV illness in humans, including 2,946 cases of neuroinvasive disease, were reported to CDC by state health departments. In 2002, a woman who had WNV encephalitis during the 27th week of her pregnancy delivered a full-term infant with chorioretinitis, cystic destruction of cerebral tissue, and laboratory evidence of congenitally acquired WNV infection. Although this case demonstrated intrauterine WNV infection in an infant with congenital abnormalities, it did not prove a causal relation between WNV infection and these abnormalities. During 2002, CDC investigated three other instances of maternal WNV infection. In all three cases, the infants were born at full term with normal appearance and negative laboratory tests for WNV infection; cranial imaging studies and ophthalmologic examinations were not performed. During 2003, CDC received reports of approximately 9,100 cases of WNV illness, including approximately 2,600 cases of neuroinvasive disease. CDC is gathering data on pregnancy outcomes for approximately 70 women with WNV illness during pregnancy.
Weston-Super-Mare
Authors: R. Alford, R. Roxburgh, E. F. Martin, F. W. S. Wicksteed, W. H. G. Phelps, G. F. Rossiter, G. E. Alford, G. B. Fraser, W. Jones, J. Wilde, W. Blundell, A. Willmott, P. B. Burroughs
Journal: BMJ (1883)
PECULIAR FORM OF HEPATITIS WITH NECROSIS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perspectives on utilization review
Authors: J. D. Porterfield
Journal: JAMA (1966)

There are two reasons why utilization review is an essential component of institutional medical practice today. The first has to do with excellence. It is true, despite frequent comment and occasional defections, that physicians have a basic desire to provide the best possible treatment for their patients, that they recognize the constantly increasing impossibility of any one man keeping up with the growth and shift of medical knowledge, that they accept the fact that medical practice can be kept at its best possible level not only by continuing study and constant reappraisal but by a regular quest for objective evaluation by their peers. The critics who object that self-policing is a case of 'I police you' and 'you police me' have the correct version. Objectivity is thereby achieved. Nor can it be overlooked that evaluation of medical practice is best done by other medical practitioners—not by nonmedical persons who do
Bladder Carcinoma
Authors: George R. Prout
Journal: New England Journal of Medicine (1972)

CarcinogenesisBLADDER carcinoma is believed to occur in humans after exposure to certain aromatic amines and is associated with bilharzial infestation in Egypt. It also occurs in domestic animals, notably Turkish cows that eat bracken fern, and may be produced in many laboratory animals with a variety of compounds.Rehn, in 1895,1 was the first to report on bladder cancers in man that may have been caused by a carcinogen. These carcinomas, termed "anilin cancers," were found in men who worked with dye stuffs, but it was not appreciated that the causative agent was probably an aromatic amine until nearly . . .
Infarction of breast fibroadenomas during pregnancy
Authors: B. Majmudar
Journal: JAMA (1975)

Two cases of infarcted fibroadenomas of the breast during pregnancy represent the total incidence of this entity from a total of 404 fibroadenomas diagnosed during the last five years in our department. Gross and microscopic pathologic findings of these breast tumors must be carefully evaluated, since the relative rarity of this lesion may lead to suspicion of carcinoma. (<i>JAMA</i>231:963-964, 1975)
The Biosynthesis of Collagen
Authors: Michael E. Grant, Darwin J. Prockop
Journal: New England Journal of Medicine (1972)

Intracellular Biosynthesis of CollagenWork from several laboratories has demonstrated that the biosynthesis of collagen occurs by a series of sequential steps: assembly on ribosomal complexes of a polypeptide precursor of collagen that we have called "protocollagen"; hydroxylation of appropriate Pro and Lys residues in protocollagen to Hypro and Hylys; and substitution of some of the Hylys residues with Gal or glucosylgalactose in O-glycosidic linkage before the molecule is extruded (Fig. 2).Our knowledge of the biosynthesis of collagen began with the experiments of Stetten and Schoenheimer, who in the 1940's prepared some of the first isotopically labeled amino acids . . .