tbuckley/cabot-search huggingface dataset:
Nondiabetic maternal hyperglycemia was associated with adverse pregnancy outcomes
Authors: Anna P. Kenyon
Journal: Annals of Internal Medicine (2008)

ACP Journal Club19 August 2008Nondiabetic maternal hyperglycemia was associated with adverse pregnancy outcomesAnna P. Kenyon, MBChB, MD, Andrew H. Shennan, MBBS, MDAnna P. Kenyon, MBChB, MDKings College, London, United Kingdom (A.P.K., A.H.S.)Search for more papers by this author, Andrew H. Shennan, MBBS, MDKings College, London, United Kingdom (A.P.K., A.H.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-4-200808190-02006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationThe HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358:1991-2002. https://pubmed.ncbi.nlm.nih.gov/18463375Clinical Impact RatingsGIM/FP/GP: Endocrinology: References1 Crowther CA, Hiller JE, Moss JR, et al. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med. 2005;352:2477-86. [PMID: 15951574] Google Scholar2 Antenatal care: routine care for the healthy pregnant woman. NICE Clinical Guideline 62; 2008. www.nice.org.uk/nicemedia/pdf/CG062QuickRefGuide.pdf. Google Scholar3 Moses R, Griffiths R, Davis W. Gestational diabetes: Do all women need to be tested? Aust NZ J Obstet Gynaecol. 1995;35:387-9. [PMID: 8717560] Google Scholar Author, Article, and Disclosure InformationAffiliations: Kings College, London, United Kingdom (A.P.K., A.H.S.)This article was published at Annals.org on 5 August 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMetformin (alone or with insulin) was as effective as insulin for preventing perinatal complications in gestational diabetes Anna P. Kenyon and Andrew H. Shennan Metrics 19 August 2008Volume 149, Issue 4Page: JC2-6KeywordsBlood plasmaCesarean sectionGestational diabetesGlucoseHyperglycemiaInsulinMedical risk factorsPopulation statisticsPregnancy ePublished: 19 August 2008 Issue Published: 19 August 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 5045: Pineal gland volume and risk of prostate cancer
Authors: Latifa A. Bazzi, Lara Sigurdardottir, Sigurdur Sigurdsson, Unnur Valdimarsdottir, Johanna Torfadottir, Thor Aspelund, Lenore Launer, Tamara Harris, Vilmundur Gudnason, Lorelei Mucci, Sarah Markt
Journal: Cancer Research (2019)

Abstract Background: The parenchyma of the pineal gland, an endocrine gland in the brain, produces the circadian hormone melatonin. Previously, we found low levels of melatonin were associated with an increased risk for advanced prostate cancer. This study used data from men in the Age, Gene/Environment Susceptibility-Reykjavik (AGES-Reykjavik) Study to evaluate the relationship between pineal volume, melatonin levels, and prostate cancer risk. Methods: Participants were enrolled in the AGES-Reykjavik Study from 2002 to 2006 and underwent detailed clinical assessments at baseline that included biospecimen collection, MRI of the brain, medical history, and health questionnaires on dietary and lifestyle factors. We included 802 men who had information on pineal size, where parenchyma, calcification, and cyst volume were estimated individually and manually from the MRIs. Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals for risk of prostate cancer during follow-up through 2014, comparing parenchyma volume tertiles. Results: There was a positive association between pineal parenchyma volume and urinary levels of melatonin. During follow-up, 135 men were diagnosed with prostate cancer, 30 of which were advanced prostate cancer. Men with volumes in the upper tertile had no statistically significant increased risk of prostate cancer compared to men with volumes in the lowest tertile (HR: 1.0, 95% CI: 0.7, 1.5), and men with volumes in the middle tertile had only a borderline statistically significant decreased risk of prostate cancer compared to men with volumes in the lowest tertile (HR: 0.7, 95% CI: 0.4, 1.0). Compared to men without pineal cysts, there was a borderline statistically significant association between men with pineal cysts and decreased risk of prostate cancer (HR: 0.7, 95% CI: 0.5, 1.0). Compared to men without pineal calcifications, there was no statistically significant association between men with pineal calcifications and increased risk of prostate cancer (HR: 1.1, 95% CI: 0.7, 1.6). Conclusions: Pineal parenchyma volume was associated with melatonin levels, but there was no statistically significant association between parenchyma volume alone and prostate cancer risk. Further studies are needed to investigate the relationship between pineal parenchyma volume, presence of calcifications and cysts, melatonin, and prostate cancer. Citation Format: Latifa A. Bazzi, Lara Sigurdardottir, Sigurdur Sigurdsson, Unnur Valdimarsdottir, Johanna Torfadottir, Thor Aspelund, Lenore Launer, Tamara Harris, Vilmundur Gudnason, Lorelei Mucci, Sarah Markt. Pineal gland volume and risk of prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5045.
Increased Focal Adhesion Kinase- and Urokinase-Type Plasminogen Activator Receptor-Associated Cell Signaling in Endothelial Cells Exposed to Asbestos
Authors: A. Barchowsky, B. M. Lannon, L. C. Elmore, M. D. Treadwell
Journal: Environmental Health Perspectives (1997)

Exposure of low-passage endothelial cells in culture to nonlethal amounts of asbestos, but not refractory ceramic fiber-1, increases cell motility and gene expression.These changes may be initiated by the fibers mimicking matrix proteins as ligands for receptors on the cell surface.In the present study, 1-to 3-hr exposures of endothelial cells to 5 mg/cm2 of chrysotile asbestos caused marked cell elongation and motility.However, little morphological change was seen when chrysotile was added to cells pretreated with either mannosamine to prevent assembly of glycophosphatidylinositol (GPI)-anchored receptors or with herbimycin A to inhibit tyrosine kinase activity.Affinity purification of GPI-anchored urokinase-type plasminogen activator receptor (uPAR) from chrysotile-exposed cells demonstrated that asbestos altered the profile of proteins and phosphoproteins complexed with this receptor.Tyrosine kinase activities in the complexes were also increased by asbestos.Immunoprecipitations with selective monoclonal antibodies demonstrated that both chrysotile and crocidolite asbestos increase kinase activities associated with p60 Src or p120 focal adhesion kinase (FAK).Further, chrysotile also changed the profile of proteins and phosphoproteins associated with FAK in intact cells.These data suggest that asbestos initiates endothelial cell phenotypic change through interactions with uPAR-containing complexes and that this change is mediated through tyrosine kinase cascades.-
Biopsy of enlarged, superficial lymph nodes
Authors: S. Sinclair
Journal: JAMA (1974)

All lymph node biopsies for enlarged, superficial lymph nodes that were performed in a general hospital over a two-year period were reviewed. Biopsies performed in patients with diagnosed malignant neoplasms or systemic illness, or to evaluate an abnormal chest x-ray film were excluded. In 63% of the cases the biopsy led to a specific diagnosis. One quarter of the patients with nondiagnostic lymph node biopsy specimens developed a disease related to the indication for biopsy, usually lymphoma. With the exception of one case, the diagnosis of lymphoproliferative disorder became evident within eight months of the original lymph node biopsy. There should be little hesitation to repeat a nondiagnostic biopsy, especially if systemic symptoms or nonlocalized adenopathy are present. (<i>JAMA</i>228:602-603, 1974)
Words.
Journal: BMJ (1988)

Lacerations to the eyelids need specialist attention if: * The lid margins have been torn -these must be sewn together accurately.* The lacrimal ducts have been damaged-the cut ends must be reapposed.* There is any suspicion ofaforeign body orpenetratingeyelid injury-objects may easily penetrate the orbit and even the cranial cavity through the orbit.Penetrating injuries of the eye can easily be missed because they may seal themselves, and the signs of abnormality are subtle.Any history of high velocity injury (particularly a hammer and chisel injury) should lead one strongly to suspect a penetrating injury.If there is any suspicion of a penetrating injury the eye should be examined very gently and no pressure should be brought to bear on the globe.
Work-Related Injury Deaths Among Hispanics—United States, 1992-2006
Journal: JAMA (2008)

The full spectrum of clinical disease is unknown.Balamuthiasis should be considered in patients with unexplained encephalitis, especially those with lymphocytic pleocytosis, elevated CSF protein (especially Ͼ100 mg/dL), and focal lesions on neuroimaging.Althoughonlysevenbalamuthiasissurvivors have been reported worldwide, early recognition of the infection might offer an opportunity to slow or stop progression of the disease. 9,10At present, the majority of cases are identified at autopsy.With improved diagnostic techniques, earlier therapeutic intervention might improve prognosis.Further studies are needed to estimate incidence, characterize risk factors, determine casefatality rates, improve diagnostic methods, and evaluate the efficacy of therapeutic interventions.An important first step will be for public health personnel, clinicians, and pathologists to become knowledgeable about this disease.
All trans‐retinoic acid decreases early mortality in patients with promyelocytic leukemia and can be given entirely on an outpatient basis
Authors: Guillermo J. Ruiz‐Argüelles, Eduardo Lobato‐Mendizábal, José Luis Delgado‐Lamas, David Gómez‐Almaguer
Journal: American Journal of Hematology (1999)

The results of the treatment of 43 patients with acute promyelocytic leukemia (PML) are reported: 27 were treated initially with all-trans-retinoic acid (ATRA), whereas 16 were treated with conventional chemotherapy. All patients received myelosuppressive chemotherapy after the initial treatment. Respectively, the complete remission rate was 92% and 37% (P < 0.01), the 5-day mortality rate was 0% and 44% (P < 0.001), and the 28-day mortality rate was 4% and 44% (P < 0.001). The median disease-free survival was 12 and 1 months (P < 0.01), whereas the 12-month disease-free survival was 50% and 13% (P < 0.01) and the 36-month disease-free survival was 41% and 9% (P < 0.01). Thirteen of the patients treated with ATRA were given the treatment fully as outpatients. ATRA given as initial therapy decreased significantly early mortality in promyelocytic leukemia patients; because some promyelocytic leukemia patients given ATRA as initial therapy can be treated as outpatients, the costs of this treatment modality may be diminished. Am. J. Hematol. 62:139–143, 1999. © 1999 Wiley-Liss, Inc.
Smoking and sport.
Journal: BMJ (1972)

geographically and shows secular changes within an area.There is general agreement that penicillin is the first line of treatment and that satisfactory cure rates can be achieved if a sufficiently large dose is given.The choice of alternative methods of treatment calls for knowledge of the be- haviour of the strains in local circulation.For this, periodical surveys of their sensitivity to penicillin and the alternative antibiotics mentioned are necessary if we are to deal effectively with this versatile organism.
Special Report
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Post-Term Pregnancies Show Slight Increase in Risk
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recombinant interferon gamma in condylomata acuminata
Authors: G. Gross
Journal: JAMA (1991)

<h3>To the Editor.</h3> — Recent studies have shown that genital warts can be effectively treated with interferon administered intralesionally.<sup>1-3</sup>This approach is not ideal since untreated lesions do not respond and pain at the injection site may limit the use of this route of administration to treat multiple lesions, which are a common clinical presentation of genital human papillomavirus infection. However, using a systemic approach, a recent international multicenter trial,<sup>4</sup>which used subcutaneous injections of recombinant interferon alfa-2a in daily doses of 3.0 mIU or 9.0 mIU three times weekly for 4 weeks, failed to demonstrate the superiority of any of the two interferon groups over the placebo group (response rates of 34% or 25%, respectively, vs 30%). In contrast, low-dose treatment with 1.5 mIU of recombinant interferon alfa-2a, which was given cyclically (daily therapy for consecutive days followed by a therapy-free interval of 4 weeks), seemed to
Instructions for authors
Authors: David Cohen
Journal: Hepatology (2016)

Observations in Hepatology submissions are intended to be outstanding case-based contributions which describe a unique presentation, novel observation, or cutting edge approach to management of a liver disease.The format should not include an abstract.It should include a brief introduction, presentation of the case (or case series), and discussion.The maximum length is 750 words, including the summary and references.There is a maximum of 2 figures or tables, and 5 references.
Presence of significant histopathology in HBeAg-positive chronic infection patients identified by four international guidelines: a Chinese multi-center study
Authors: Yidi Jia, Haoxiang Zhu, Xun Qi, Minhui Dong, Xueping Yu, Jingjing He, Jingwen Wu, Jing Li, Xueyun Zhang, Richeng Mao, Yanli Qin, Yuxian Huang, Jie Yu, Jiming Zhang
Journal: Journal of Hepatology (2020)
Auntie Joan
Authors: Richard Ashford
Journal: BMJ (2004)

of about 5 million, in the year 2002, there were more than 3.8 million individual prescriptions for antidepressants, an increase of 7% on the previous year. 19 The recognition that such a serious condition with an estimated mortality of about 20%, even higher rates being reported in patients known to have organic brain disease, can occur with such commonly prescribed drugs would appear to be an important lesson. 20 We thank David Clark for his helpful comments on an earlier draft.
Contents page, Editorial Board
Authors: Sian Lewis, Federica Giovannini, Manpreet Coordinator, Manager Moulton, Anders Björklund, Sweden Lund, Sarah Paul Bolam, Barry Dickson, John Disterhoft, Chris Doe, Yukiko Goda, Mark Mattson, Richard Morris, Venkateshn Murthy, Maiken Nedergaard, Nancy Rothwell, Mike Shadlen, Anne Kemp, Denise Manahan-Vaughan, Astrid Scheschonka, Zhongshu Tang, Heinrich Betz, Mark Rich, Peter Wenner, R Liu, Dietmar Plenz, Tara Thiagarajan, Andreas Schaefer, Troy Margrie, Leslie Kay, S Sherman, Hanna Parnas, Itzchack Parnas, Dopamine Space, W Gordon, Jeff Arbuthnott, Philip Joris, Tom Yin, François Giuliano
Journal: Trends in Neurosciences (2007)
Lymphoproliferative Diseases
Authors: Yeu-Tsu N. Lee
Journal: JAMA (1975)

According to the preface, this volume was compiled to gather in one volume pertinent material dealing with non-Hodgkin lymphoma. But the title, "Lymphoproliferative Diseases," suggests a more heterogeneous group of malignant and non-malignant conditions. Thus, there are chapters dealing with sarcoidosis, Waldenstrom macroglobinemia, myelomatosis, histiocytosis X, and even lymphosarcoma and related diseases in animals. All of these chapters are excellent, and the clinicopathological manifestations and current laboratory and research findings are well presented. Many fine tables, line drawings, and clinical photographs highlight the special points made in the text. Burkitt tumor is also superbly covered. The first ten chapters discuss various aspects of non-Hodgkin lymphoma. Because there are multiple authors, several topics such as immunoglobulin abnormalities and infectious complications appear more than once. There are no microscopic illustrations when the pathologic anatomy of non-Hodgkin lymphoma is described. Immunoglobulin and other immunological abnormalities are discussed in two chapters, but many re
Unreviewed Reports
Journal: BMJ (1984)

Unreviewed ReportsTwo cases of hereditary haemorrhagic telangiectasia of the bronchus Though gastrointestinal and urinary tract lesions are well documented in hereditary haemorrhagic telangiectasia, lower respiratory tract lesions are not.A 74 year old man, admitted with acute chronic bronchitis and known hereditary haemorrhagic telangiectasia, had tracheal telangiectasia on bronchoscopyl; at necropsy some months later widespread bronchial telangiectasia was found.A 35 year old man with profuse haemoptysis had telangiectasia inside his lower lip but no other abnormal findings.Bronchoscopy showed telangiectasis at the carina and in the main bronchi, which was profuse at the origin of the bronchus of the left upper lobe.Bronchial anteriography showed a large feeding artery and a hypervascular segmental bronchial supply in the left upper lobe.
POSTGRADUATE MEDICAL INSTRUCTION IN VIENNA
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reports on Sanitary Engineering in Houses, Hospitals, and Public Institutions
Authors: W. Eassie
Journal: BMJ (1874)

THE ordinary fireplace of the present day is a disgrace to our comm1iiiunity, for it permits fully tlhree-fourths of the fuel consumed in the grate to be completely w-asted.The objections to be urged against it are many.Besides those of sw aste and incomplete and unequal heating, are the draughts of cold air which flowr firewards, to the great inconvenience of the occupanits of the room ; the inisufficient ventilation of the apart- mnent, the aptittude to smoke, and the prevalence of dust ; the cost of fiequenit chininey-sweeping which it necessitates, the labour of having conitinutially to suipply fuel for combustioni, and the risk of fire to person and to property \N-hich it alwayi renders possible.The use of objectionable grates is still persisted in, it w-ould seem, because they are cheap, and because the commonest workman cani fix them.It is in the cottages of our artisans that the worst specimens are to be found ; but mainy patternis nearly as bad are foisted into the drawving and other rooms of the upper classes.A good fireplace admits of a steady consumption of fuel, and cloes not waste it.All the heat produced by combustion is realised in the room - the fire needs little attention, and no poking to keep it from formning black cinders ; and, whilst the room is sufficiently wsarmed at the ex- pense of a minimumn amount of firing, a thorough ventilation is secured.The majority of the best residences are now supplied w ith register- stoves, aild fitted uip with fire-clay lumps.Compared with the older l)atterns in use before Count Rumford's time, these have done excellent -work.When fresh air is led fiom the exterior atmosphere to these and all other grates, a conisiderable improvement is added.It will niot be necessary in a journal like this, however, to point out what doubtless every reader kniows by experience: I shall, therefore, now describe a few of the best grates which combine warming wvith ventilation, then give a description of smokeless and slow combustioni grates, and conclude this paper w'ith a notice of several of the best kinds of stoves.Open Ventilating Graes.-This is the name now given to those grates and stoves which are immediately connected with chambers into which freslh air from the otutside is led and heated, and out of which such warmed air is passecl into the room.They are destined sooni to replace all the more old-fashioned articles, not onily because by their a(loption the heat is utilised, draughts rendered impossible, an(d due ventilation secured, but because they offer facilities for heating adljoining rooms, or rooms in the upper stories, from one and the same fire, .simplyby lea(ling tubes to these places from the warmn air chambers.It may, therefore, be as well to describe a few of the more important kinds.