tbuckley/cabot-search huggingface dataset:
Male breast cancer: Molecular pathology and demographics of a case series
Authors: S. Pant, S. Venkatappa, S. Sethi, S. Lightfoot, A. Tfayli, H. Ozer
Journal: Journal of Clinical Oncology (2004)

9723 Background: Male breast cancer is a rare disease with approximately 1500 new cases diagnosed in the United States each year. Most of the available data on this disease are descriptive information from small patient series. These reviews often have incomplete pathological information and no data on long term follow up, thus identifying the need to improve the understanding of the demographics, genetic characteristics and prognosis of this group of patients in the United States. In this abstract we report updated information from a retrospective review of a relatively large series of male breast cancer patients. Methods: This retrospective review of a case series was performed on a group of 30 male patients whose cell blocks were procured from various Veterans Affairs Medical Centers (VAMC) from around the country. Demographic data were obtained from chart review and the VAMC tumor registries. Each cell block was examined for p53, ER, PR, Her-2/Neu and BRCA 1. Results: The average age at diagnosis was 68.5 years with a range between 39 and 90. Of the 30 patients, race data were available on 18 patients with 13 being Caucasian and 5 African American. 13 tumors occurred in the left breast and 10 in the right breast. Demographic data were not available for the remaining 7 cases. Staging was available for 19 cases. 4 cases were diagnosed at stage I, 6 cases at stage IIa, 3 cases at IIb, 1 case at stage IIIa, 3 cases at IIIb and 2 cases at stage IV. 12 of the 29 cases were Her-2/Neu positive (3+), 27 cases were both ER and PR positive while one case was ER positive and PR negative while another case was ER negative and PR positive. 22 of the 29 patients were P53 positive. All 29 cases were negative for BRCA 1 gene mutations. 20 of the 27 cases in this series are alive with a median survival of 39 months (range 9–140 months) from the date of diagnosis. Conclusions: This is one of the few case series of male breast cancer patients that provides demographic and pathological data on this rare disease in the United States. These cases are being followed for survival and these data will be updated when available. Larger prospective studies are needed to identify the risk factors and the ideal treatment for male breast cancer. No significant financial relationships to disclose.
银屑病严重程度的定义
Authors: M. Augustin, A. Langenbruch, M. Gutknecht, K. Reich, A. Korber, D. Maassen, U. Mrowietz, D. Thaci, R. von Kiedrowski, M.A. Radtke
Journal: British Journal of Dermatology (2018)

由于各种原因,衡量患者的银屑病严重程度非常重要。例如,它使医生能够选择正确的治疗水平,然后观察治疗效果如何,它还使研究人员能够对相似患者的不同疗法进行比较。一些被称为全身疗法的治疗方法作用于全身而不仅仅是皮肤,它们只适用于“中度至重度”疾病患者。银屑病严重程度的测量通常基于两种不同的评分系统:银屑病面积和严重指数 (PASI) 和皮肤病生活质量指数 (DLQI)。PASI 用于记录患者银屑病的发红程度、厚度和范围,并用于衡量疗效(PASI 分值降低,即表示症状减轻)。DLQI 包含 10 个问题,涉及皮肤病患者在过去一周内关于生活质量 (QoL) 的各个不同方面(包括症状和感觉、日常活动、休闲、工作或学习、人际关系以及治疗的副作用)受到皮肤病影响的感受。分数越高说明 QoL 受到的损害越大。然而,并不是所有的指南都对如何结合 DLQI 和 PASI 的结果给出了相同的建议;例如,有些指南认为 DLQI 和 PASI 的评分都 >10 表明是中度至重度银屑病,而其他指南则认为 DLQI 或 PASI 的评分 >10 表明是中度至重度银屑病。在这项来自德国的研究中,研究人员同时基于或者分别基于 PASI 和 DLQI 对 3274 名患者的数据进行了分析。PASI 和 DLQI >10的患者比例为 14.0%,但 45.3% 的患者至少达到 PASI 或 DLQI >10。因此,为了更可靠的治疗和保健规划,作者提议了一个国际标准化。
The Practice of Pediatrics.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE NURSING SHORTAGE
Journal: JAMA (1967)

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The International Medical Annual and Practitioner's Index
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In the Spotlight: BioInstrumentation
Authors: Ken-ichi Yamakoshi
Journal: IEEE Reviews in Biomedical Engineering (2012)

The present review deals with three notable topics from recent publications in the field of bioinstrumentation. These are: (1) new conducting polymer electrodes for in vivo bio-electrical measurements; (2) mHealth technology using mobile communication devices such as mobile phones and personal digital assistants (PDAs); and (3) noninvasive in vivo measurement of blood constituents. These topics are of recent or renewed interest and, where appropriate, progress since the previous reviews [1], [2] will be highlighted.
Correction: Pomalidomide, bortezomib, and low-dose dexamethasone in lenalidomide-refractory and proteasome inhibitor-exposed myeloma
Authors: P. G. Richardson, C. C. Hofmeister, N. S. Raje, D. S. Siegel, S. Lonial, J. Laubach, Y. A. Efebera, D. H. Vesole, A. K. Nooka, J. Rosenblatt, D. Doss, M. H. Zaki, A. Bensmaine, J. Herring, Y. Li, L. Watkins, M. S. Chen, K. C. Anderson
Journal: Leukemia (2018)

Following the publication of this article, the authors noted that the pomalidomide dose for the additional SC cohort in Fig. 1 was incorrectly listed. The correct dose for pomalidomide in the additional SC cohort should be the maximum tolerated dose of 4 mg/day, not 2 mg/day as listed in the original Fig. 1. The authors apologize for any inconvenience caused.
Multiphasic screening for preschool children. I. Methodology and clinical findings in a Spanish-American community
Authors: H. B. Brown
Journal: JAMA (1972)

Two pediatric screening clinics staffed by students and community volunteers were conducted in low-income, Spanish-American neighborhoods in Albuquerque, NM. The program was designed to examine preschool children by means of history, physical examination, hematocrit, urinalysis, and psychological tests. Three hundred and fifty-two children were examined. Abnormalities in the results of laboratory tests or physical examination were identified in 59 (17%). Information on the results of further evaluation of suspected abnormalities is incomplete but suggests that approximately 5% of the children had chronic physical impairment and that 7% had significant emotional or mental impairment.
Diagnosing streptococcal pharyngitis
Authors: E. L. Kaplan
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The article entitled "Insensitivity of Rapid Antigen Detection Methods and Single Blood Agar Plate Culture for Diagnosing Streptococcal Pharyngitis" by Wegner and colleagues,<sup>1</sup>while attempting to assist clinicians in management of group A streptococcal infections, unfortunately reaches unjustified conclusions without taking a number of important factors into consideration. First and most important, it is very difficult to believe that experienced microbiologists can find group A streptococci on only 58% of the plates after 24 hours and on only approximately 70% of the plates after 2 days. Even if there is an accepted discordance rate (one positive and one negative) of about 10% when using two swabs as shown in reference 8 of the article, this still indicates that those who read the single plates missed about 20%. This is unacceptably high for a laboratory. The authors could have attempted to explain this unexpected finding by performing
Controversies About Brain Death
Authors: Franklin G. Miller
Journal: JAMA (2009)

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BLUE URINE.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized, Double-Blind Trial of Olanzapine Versus Placebo in Patients Prodromally Symptomatic for Psychosis
Authors: Thomas McGlashan
Journal: American Journal of Psychiatry (2006)

Objective: This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia. Method: This randomized trial occurred at four North American clinics in the Prevention Through Risk Identification, Management, and Education project. Outpatients received olanzapine (5–15 mg/day, N=31) or placebo (N=29) during a 1-year double-blind treatment period and no treatment during a 1-year follow-up period. Efficacy measures included the conversion-to-psychosis rate and Scale of Prodromal Symptoms scores. Results: During the treatment year, 16.1% of olanzapine patients and 37.9% of placebo patients experienced a conversion to psychosis, a nearly significant difference. The hazard of conversion among placebo patients was about 2.5 times that among olanzapine-treated patients, which also approached significance. In the follow-up year, the conversion rate did not differ significantly between groups. During treatment, the mean score for prodromal positive symptoms improved more in the olanzapine group than in the placebo group, and the mixed-model repeated-measures least-squares mean score showed significantly greater improvement between weeks 8 and 28 with olanzapine. The olanzapine patients gained significantly more weight (mean=8.79 kg, SD=9.05, versus mean=0.30 kg, SD=4.24). Conclusions: A significant treatment difference in the conversion-to-psychosis rate was not demonstrated. However, these results may be influenced by low power. The nearly significant differences suggest that olanzapine might reduce the conversion rate and delay onset of psychosis. Olanzapine was efficacious for positive prodromal symptoms but induced weight gain. Further treatment research in this phase of illness is warranted.
THE EFFECTS OF LOSS OF GASTRIC JUICE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
São Paulo, Brazil
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Guidelines of the Council on Environmental Quality for the Preparation of Environmental Impact Statements
Authors: Beatrice E. Willard
Journal: Environmental Health Perspectives (1975)

Definitions and the seven principles of ecology are listed. NEPA expresses or implies all seven. Section 101 is quoted in illustration. CEQ Guidelines implement Sec. 102(2)(C). The reasons for initial delays in implementation are reviewed; these are now largely resolved. The policy involves action through integrating engineering, economics and ecology. Alternative actions must be considered, and short-term effects weighed against the long-term goals. Twelve modes of approach are advocated.
Dermatomyositis
Authors: Katie A. O’Connell, Avery H. LaChance
Journal: New England Journal of Medicine (2021)

A 66-year-old woman presented with a pruritic rash, fatigue, and muscle weakness. On examination, hyperpigmented, erythematous papules were observed on her hands and dyschromic patches and plaques were noted on her posterior shoulders. A diagnosis of dermatomyositis was made.
Donor type microchimerism is an infrequent event following liver transplantation and is not associated with graft acceptance
Authors: S Norris, M Lawler, S McCann, J Hegarty, C O'Farrelly
Journal: Hepatology (1997)

Donor-type microchimerism, the presence of a minority population of donor-derived haematopoietic cells following solid organ transplantation, has been postulated as a mechanism for induction of donor-specific graft tolerance. The stability, frequency, and relevance of microchimerism with respect to long-term outcome, however, remains uncertain. Using a polymerase chain reaction (PCR)-based method of microsatellite analysis of highly polymorphic short tandem repeat sequences (STRs) to detect donor-type cells, DNA from 11 patients was analyzed prospectively at specific time points for 12 months following liver transplantation, and from a further six patients retrospectively 2 years after liver transplantation. Using a panel of STRs, transient peripheral blood donor microchimerism was detected in 2 of 11 patients at a single time-point following transplantation, but persistent evidence of donor-derived cells was not observed during the study period. Analysis of DNA extracted from skin and duodenum in two patients likewise failed to show donor-type cells at these sites. None of the six patients in the retrospective arm showed donor microchimerism, resulting in an overall detection rate of 1.58%. These results suggest that donor microchimerism following liver transplantation is an infrequent event, and that the generation of graft tolerance is independent of microchimerism.
Safety and efficacy of up to 76 weeks 10 mg (high dose) bulevirtide monotherapy in compensated cirrhotics with delta hepatitis
Authors: Alessandro Loglio, Peter Ferenci, Franziska Schlund, Christine Y.L. Tham, Florian van Bommel, Sara Colonia Uceda Renteria, Marta Borghi, Heidemarie Holzmann, Riccardo Perbellini, Elena Trombetta, Silvia Giovanelli, Laura Porretti, Daniele Prati, Ferruccio Ceriotti, Giovanna Lunghi, Antonio Bertoletti, Stephan Urban, Pietro Lampertico
Journal: Journal of Hepatology (2020)
Merits, Flaws of Live Virus Flu Vaccine Debated
Authors: C. Marwick
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A METHOD FOR SOLIDLY INCORPORATING METAL REINFORCEMENTS IN PLASTER CASTS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal