tbuckley/cabot-search huggingface dataset:
Facilitation of Long-Term Potentiation by Muscarinic M1 Receptors Is Mediated by Inhibition of SK Channels
Authors: Katherine A. Buchanan, Milos M. Petrovic, Sophie E.L. Chamberlain, Neil V. Marrion, Jack R. Mellor
Journal: Neuron (2011)

(Neuron 68, 948–963; December 8, 2010) The original publication omitted one affiliation for Dr. M. Petrovic: Institute of Medical Physiology, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia. This affiliation has been added to the article online. Facilitation of Long-Term Potentiation by Muscarinic M1 Receptors Is Mediated by Inhibition of SK ChannelsBuchanan et al.NeuronDecember 09, 2010In BriefMuscarinic receptor activation facilitates the induction of synaptic plasticity and enhances cognitive function. However, the specific muscarinic receptor subtype involved and the critical intracellular signaling pathways engaged have remained controversial. Here, we show that the recently discovered highly selective allosteric M1 receptor agonist 77-LH-28-1 facilitates long-term potentiation (LTP) induced by theta burst stimulation at Schaffer collateral synapses in the hippocampus. Similarly, release of acetylcholine by stimulation of cholinergic fibers facilitates LTP via activation of M1 receptors. Full-Text PDF Open Access
The Commoner Diseases of the Eye, How to Detect and How to Treat Them. For Students of Medicine. With 250 Illustrations, Many of Them Original, of Which 7 are Colored Plates.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Echocardiographic abnormalities of interventricular septum associated with "absent Q" syndrome
Authors: G. E. Burch
Journal: JAMA (1974)

Echocardiograms of interventricular septal motion were recorded in patients with cardiomyopathy to learn if absence of a septal Q wave, "electrical silence," in the electrocardiogram is associated with a noncontracting, "mechanically silent," septum. Patients with cardiomyopathy with absence of septal Q waves in the ECG had an associated absence of normal motion of the interventricular septum. As would be expected electrical silence of the septum was associated with mechanical silence. These findings indicated cardiomyopathic disease of the interventricular septum in these patients. (<i>JAMA</i>228:1665-1666, 1974)
Rockaway
Authors: Floyd Skloot
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
APPLIED ANTHROPOMETRY
Authors: Horace Gray
Journal: JAMA (1924)

In a recent paper<sup>1</sup>on a possible use of body diameters in the practice of medicine, two other possibilities were hinted at. Some suggestive evidence prompts this preliminary note, partly because of probable delay in securing final proof, and partly because of the potential value of these two postulates: Body weight appears to vary as the greatest diameter of the pelvis (cristal breadth, outer edges). This is indicated by the uniformity and slope of the curve resulting from plotting points for these two variables, recorded for both individuals and groups, as in the accompanying chart. Differential diagnosis between ulcer and gallbladder disease may be aided by ratios between chest measurements and height. The chest girth (xiphoid level, midrespiratory phase) amounted to at least 48.1 per cent. of the height in each of eleven women with gallstones, but in four women with ulcer the ratio was 47.5 or less. The
In vivo measurement of bone mass. Its use in demineralized states such as osteoporosis
Authors: D. M. Smith
Journal: JAMA (1972)

In a sensitive method for measuring both cortical and trabecular bone mass in the radius, bone mass is determined by measuring the photon energy absorbed by bone from a monochromatic gamma-ray source,<sup>125</sup>I. The method is quite reproducible, with a coefficient of variation of about 2.5%. Measurements of bone mass were performed on 169 white women older than 50 years of age who were divided into two groups: those with (56 women) and those without collapsed vertebrae (113 women). Measurements of both trabecular and cortical bone mass were significantly less in the group with collapsed vertebrae. This method is capable of providing objective, reproducible measurements of bone mass in man. It appears to be a very promising tool for the study of the natural history of diseases of demineralization and for providing data on the response to therapy.
Incorrect Information
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 240: Therapeutic targeting of protein kinase ck2 in mycn-driven neuroblastoma
Authors: Haiwei Lian, Ning Shen, Yun Zhou, Dun Li, Hui Feng
Journal: Cancer Research (2019)

Abstract Amplification of the MYCN oncogene occurs in about 30-40% of advanced neuroblastoma cases and is the most reliable predictor of poor prognosis. Protein kinase CK2 (casein kinase II) is a highly conserved serine/threonine kinase that can be effectively inhibited by small molecules. In fact, CX-4945, a potent, specific, ATP-competitive CK2 inhibitor, is currently tested in clinical trials to treat multiple cancers. However, the role of CK2 in MYCN-driven neuroblastoma remains unknown. To determine the relevance of CK2 in MYCN-driven neuroblastoma pathogenesis, we analyzed published microarray data and compared the expression of the CK2 subunits in primary neuroblastoma patients samples. We found that both CK2α and CK2α’ are upregulated in neuroblastoma patients samples with MYCN amplification, compared to the ones without MYCN amplification. To determine the effect of CK2 inhibition on neuroblastoma cells, we treated a panel of human neuroblastoma cell lines with the CK2 inhibitor CX-4945 and short hairpin RNA specifically targeting CK2α. CK2 inhibitor CX-4945 suppressed human neuroblastoma cell growth, mainly through inducing apoptosis, especially in the MYCN-amplified cells. More over, CK2α knockdown also induced cell apoptosis. In-vitro assay indicated that CK2 inhibition through either genetic or pharmacological approaches effectively reduced cell growth of human neuroblastoma cells primarily through induction of apoptosis. 14 days in-vivo treatment, CX-4945 significantly decreased tumor growth in mouse xenografts by subcutaneously implanting human KELLY neuroblastoma cells, but didn’t affect their body weight. These studies characterize the role of CK2 in neuroblastoma development, and provide valuable information about the relevance of CK2 as a target in MYCN-driven neuroblastoma. Note: This abstract was not presented at the meeting. Citation Format: Haiwei Lian, Ning Shen, Yun Zhou, Dun Li, Hui Feng. Therapeutic targeting of protein kinase ck2 in mycn-driven neuroblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 240.
Correction: The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA
Authors: H. Mandel, R. Szargel, V. Labay, O. Elpeleg, A. Saada, A. Shalata, Y. Anbinder, D. Berkowitz, C. Hartman, M. Barak, S. Eriksson, N. Cohen
Journal: Nature Genetics (2001)
Selective coronary arteriography. Risk in a community hospital
Authors: W. F. Weaver
Journal: JAMA (1976)

Over a 33-month period, selective coronary arteriography was performed in 627 consecutive patients in a 385-bed, non-university-affiliated community hospital. Mortality was 0.16% (one death); there was also one nonfatal myocardial infarction. No deaths or myocardial infarctions occurred in the last 369 consecutive patients in this series when routine systemic heparinization was introduced. Substantially greater risk of mortality (2.6%) and nonfatal myocardial infarction (2.6%) was encountered in an earlier series of 78 consecutive patients for whom a different protocol was used. It included extensive exercise hemodynamic studies with the use of percutaneous arterial angiographic catheters, without systemic heparinization. This indicates that coronary arteriography can be carried out with acceptable risk in a community hospital. Protocols should be designed to minimize the time that catheters are in the arterial system. Systemic heparinization may reduce the risk of procedure-related death and myocardial infarction. (<i>JAMA</i>235:819-822, 1976)
DISHEARTENED CHILDREN.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arboviral Surveillance—Florida, 1990
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mise en place d’une check-list avant coloscopie: une initiative d’amélioration de la qualité
Journal: Endoscopy (2018)

Introduction: Les check-lists jouent un rôle dans la prévention des erreurs et ont un impact positif dans différents contextes chirurgicaux et probablement aussi en endoscopie digestive. L’objectif de cette étude était de renforcer l’engagement dans la culture de la sécurité opératoire et d’encourager une meilleure communication entre les membres de l’équipe d’endoscopie ainsi que de prouver la faisabilité de l’adoption d’une check-list efficace avant coloscopie.
Serum immunoreactive erythropoietin in HIV-infected patients
Authors: J. L. Spivak
Journal: JAMA (1989)

Serum immunoreactive erythropoietin (SIE) and hemoglobin levels were measured in 152 patients infected with the human immunodeficiency virus. Anemia was present in 18% of asymptomatic patients who tested positive for the human immunodeficiency virus, 50% of patients with a condition related to the acquired immunodeficiency syndrome (AIDS), and 75% of patients with AIDS. The mean SIE level for untreated AIDS patients (26.2±2.4 mU/mL) was greater than for patients who tested positive for human immunodeficiency virus or patients with an AIDS-related condition but not outside the normal range for SIE (4 to 26 mU/mL), and the incremental increase in SIE level for a given decline in hemoglobin level was much less in AIDS patients than in patients with uncomplicated iron deficiency anemia. Forty-two patients were treated with zidovudine, and the hemoglobin level fell 10 g/L or more in 48%. In contrast to the untreated patients, however, the mean SIE level rose 10-fold to 214 mU/mL, and the incremental change in SIE level for a given decline in hemoglobin level was markedly increased. In the zidovudine-treated patients, erythrocyte mean corpuscular volume also rose significantly from a mean of 88.1 fL to 102 fL. However, in only 1 patient was there a corresponding increase in reticulocytes and in none was there amelioration of anemia. The data indicate that SIE level is inappropriately low in anemic AIDS patients. The ability of these patients to produce erythropoietin is intact and can be expressed with zidovudine therapy. However, even very high levels of SIE fail to stimulate erythropoiesis adequately. (<i>JAMA</i>. 1989;261:3104-3107)
Significance of natural polymerized albumin and its receptor in hepatitis B infection of hepatocytes
Authors: S Dash
Journal: Hepatology (1991)

Lack of information regarding the presence of native albumin polymer in serum and its structural similarity to the one produced by glutaraldehyde treatment casts doubt on the postulate that hepatitis B virus attachment to hepatocytes is mediated through polymerized albumin. We used a sandwich enzyme-linked immunosorbent assay with murine monoclonal antibodies raised against glutaraldehyde-polymerized albumin to detect native albumin polymer in human serum and its cross-reactivity with other albumin polymers. Presence of polymerized albumin receptor on the HepG2 cell was studied by radioreceptor assay. Purified hepatitis B virus and synthetic peptide analogous to part of pre-S2 sequence (120–145) were used to study polymerized albumin-dependent attachment of the virus to HepG2 cells. Antibodies raised against pre-S2 peptide were used to inhibit the pre-S2 and hepatitis B virus attachment to HepG2 cells. Glutaraldehyde-treated polymerized albumin was found to be immunologically cross-reactive with native albumin polymer. Its levels were found to be significantly raised in sera of patients with liver diseases. Polymerized albumin has specific saturable receptor on HepG2 cells with two classes of binding sites of different equilibrium dissociation constant (Kd1) = (16 ± 9.6)pmol/L and Kd2 = (1,019 ± 172)pmol/L. Albumin monomer was unable to compete for the polymerized albumin receptor sites on HepG2 cells. Antipre-S2 antibodies inhibit hepatitis B virus and pre-S2 binding to hepatocyte by 40% and 70%, respectively. Added extraneous polymerized albumin and the antibody against it did not interfere with virus attachment to HepG2 cells. (HEPATOLOGY 1991;13:134–142).
Reports of clinical trials should begin and end with up-to-date systematic reviews of other relevant evidence: a status report
Authors: M. Clarke, S. Hopewell, I. Chalmers
Journal: Journal of the Royal Society of Medicine (2007)

Scientific and ethical justification for new clinical trials requires them to have been designed in the light of scientifically defensible assessments of relevant previous research. Reliable interpretation of the results of new clinical trials entails setting them in the context of updates of the reviews upon which they were deemed scientifically and ethically justifiable. We have shown previously that most reports of randomized trials published in five general medical journals in May 1997 and in May 2001 failed to set their results in the context of the findings from similar research. In the current study, we assess whether there had been progress in this respect in 2005 and also investigate the extent to which reports begin by referring to systematic reviews providing the justification for the new research reported.
State Charities Aid Association of New York.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PHOTOFLUOROGRAPHY IN GASTRIC CARCINOMA
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term follow-up of thoracoscopic talc pleurodesis for primary spontaneous pneumothorax
Authors: I. Oransky
Journal: European Respiratory Journal (2007)

Long-term follow-up of thoracoscopic talc pleurodesis for primary spontaneous pneumothoraxTo the Editors:I read with interest the study by GYO ¨RIK et al.[1] of talc pleurodesis for primary spontaneous pneumothorax.The results were not surprising as they confirm previous studies.What was surprising, however, was the lack of a control group, the lack of an intention-to-treat analysis and the failure of the paper's discussion to mention these absences as a weakness.The authors report a 95% long-term success rate for talc pleurodesis, which represents 53 out of 56 patients initially treated successfully with the technique.There were, however, 112 patients who underwent the procedure.The authors were only able to contact 63 of them; the remaining 49 apparently were not contactable because of ''geographical movement.''I am troubled that an intention-to-treat analysis is not reported.Given the 53 long-term successes and 112 original treatments, I arrive at a success rate of 47%, which is half of what the authors report.Together with the lack of a control group of patients who suffered spontaneous pneumothoraces but did not undergo talc pleurodesis, I find it unclear as to what can be reliably concluded from this study.