tbuckley/cabot-search huggingface dataset:
Phase I Study of the Intravenous Administration of Attenuated<i>Salmonella typhimurium</i>to Patients With Metastatic Melanoma
Authors: John F. Toso, Vee J. Gill, Patrick Hwu, Francesco M. Marincola, Nicholas P. Restifo, Douglas J. Schwartzentruber, Richard M. Sherry, Suzanne L. Topalian, James C. Yang, Frida Stock, Linda J. Freezer, Kathleen E. Morton, Claudia Seipp, Leah Haworth, Sharon Mavroukakis, Donald White, Susan MacDonald, John Mao, Mario Sznol, Steven A. Rosenberg
Journal: Journal of Clinical Oncology (2002)

PURPOSE: A strain of Salmonella typhimurium (VNP20009), attenuated by chromosomal deletion of the purI and msbB genes, was found to target to tumor and inhibit tumor growth in mice. These findings led to the present phase I study of the intravenous infusion of VNP20009 to patients with metastatic cancer. PATIENTS AND METHODS: In cohorts consisting of three to six patients, 24 patients with metastatic melanoma and one patient with metastatic renal cell carcinoma received 30-minute intravenous bolus infusions containing 10 6 to 10 9 cfu/m 2 of VNP20009. Patients were evaluated for dose-related toxicities, selective replication within tumors, and antitumor effects. RESULTS: The maximum-tolerated dose was 3 × 10 8 cfu/m 2 . Dose-limiting toxicity was observed in patients receiving 1 × 10 9 cfu/m 2 , which included thrombocytopenia, anemia, persistent bacteremia, hyperbilirubinemia, diarrhea, vomiting, nausea, elevated alkaline phosphatase, and hypophosphatemia. VNP20009 induced a dose-related increase in the circulation of proinflammatory cytokines, such as interleukin (IL)-1β, tumor necrosis factor alpha, IL-6, and IL-12. Focal tumor colonization was observed in two patients receiving 1 × 10 9 cfu/m 2 and in one patient receiving 3 × 10 8 cfu/m 2 . None of the patients experienced objective tumor regression, including those patients with colonized tumors. CONCLUSION: The VNP20009 strain of Salmonella typhimurium can be safely administered to patients, and at the highest tolerated dose, some tumor colonization was observed. No antitumor effects were seen, and additional studies are required to reduce dose-related toxicity and improve tumor localization.
Dr. McGrath and Colleagues Reply
Authors: P. J. McGRATH, J. W. STEWART, M. FAVA, M. H. TRIVEDI, S. R. WISNIEWSKI, A. A. NIERENBERG, M. E. THASE, L. DAVIS, M. M. BIGGS, K. SHORES-WILSON, J. F. LUTHER, D. WARDEN, A. J. RUSH
Journal: American Journal of Psychiatry (2007)
Myxedema Ileus
Authors: Ali A. Abbasi
Journal: JAMA (1975)

Myxedema ileus uncommonly complicates the hypothyroid state. It is a rare cause of intestinal pseudo-obstruction that can be reversed with thyroid hormone therapy. Our two patients with myxedema ileus had concurrent infection. Intestinal ileus was completely reversed with the administration of thyroid hormone. (<i>JAMA</i>234:181-183, 1975)
Introduction to Psychobiology and Psychiatry: A Textbook for Nurses
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elbow dislocations
Authors: R. L. Linscheid
Journal: JAMA (1965)

Of 110 elbow dislocations seen during a 15-year period at the Mayo Clinic, two were anterior and 108 were varieties of posterior dislocations. Dislocation commonly resulted in rupture of the collateral ligament attachments and in late slight heterotopic bone formation in the collateral ligaments. Avulsions of the epicondyles and fracture of the radial head were common accessory fractures. Avulsion of the medical epicondylar epiphysis is frequent and may predispose the joint to further injury. Injury to the ulnar nerve was approximately three times more common than was injury to the median nerve. Arterial injuries were noted in six dislocations and were always associated with persistent neurological findings. The late results were largely dictated by the severity of the original injury. The outlook in uncomplicated dislocations is good.
Abstract 4966: Characteristics of immune repertoires in early lung cancer patients
Authors: Jin Wang, Xihao Hu, Peng Zhang, Xiaole Shirley Liu
Journal: Cancer Research (2019)

Abstract Lung cancer is the leading cause of cancer death in the world, and early lung cancer detection is vital for improving the overall survival. Besides x-ray and CT scan, few genetic tests have been widely used for detecting early lung tumors. We hypothesize that early lung cancer patients have some unique features in the immune repertoires which can be utilized for early cancer detection and profiling disease development. In this study, we performed RNA-seq for paired tumor and tumor-adjacent normal samples from 59 early lung adenocarcinoma patients. We found that early lung tumors have more cytokine activities, higher B cell and CD4+ T cell infiltration, and lower CD8+ T cell infiltration compared to normal lung tissues. We assembled B cell receptors from RNA-seq reads and found more B cell clonal expansion and somatic hypermutations in the tumor than in tumor-adjacent normal tissues, similar to the B cell repertoires in late-stage lung cancer patients. In both early- and late-stage lung tumors, we identified a few cytokines that positively correlated with more IgA isotypes and associated with patient survival. To gain more insights on the B cell binding specificity, we performed motif enrichment analysis for paired tumor and normal samples and validated some tumor-enriched receptor motifs in matched patient blood samples, which implies a new way of early cancer detection. More interesting, we assembled microbial transcripts from RNA-seq data and identified some known lung disease-related species in both tumor and normal samples. The complex interactions between cancer cells, B cells, and microbiota in the early lung tumor development are waiting to be elucidated. Citation Format: Jin Wang, Xihao Hu, Peng Zhang, Xiaole Shirley Liu. Characteristics of immune repertoires in early lung cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4966.
Nonpigmented Serratia marcescens
Authors: E. Clayton
Journal: JAMA (1966)

One hundred and eighty-one isolations of nonpigmented<i>Serratia marcescens</i>from 104 patients were made during a one-year period, most of them from urines and sputa. Patients with positive cultures had either a preexisting local disease, a history of instrumentation (catheterization, treatment with an intermittent positive pressure breathing device) or operation, or both. Other contributing factors were impaired general resistance and preceding antibiotic treatment. An evaluation of the role of Serratia in the course of each case proved difficult. However, the virulence of our strains seemed to be low. Few symptoms could be attributed exclusively to Serratia infections. Emergence after antibiotic treatment, resistance to many antibiotics, prevalence in hospital patients, and typical ward epidemics suggest that Serratia is a predominantly hospital-acquired organism. It may constitute a potential danger to debilitated patients, and its finding should not be dismissed as meaningless.
Activation ot the aryl hydrocarbon receptor sensitizes to acetaminophen-induced acute liver failure
Authors: Fenja Schuran, Christoph Lommetz, Steudter Andreas, Wieschendorf Björn, Dorothee Schwinge, Christoph Schramm, Ansgar W. Lohse, Johannes Herkel, Antonella Carambia
Journal: Journal of Hepatology (2020)
From the authors
Authors: C. P. van Schayck, M. Mommers, E. D. Dompeling
Journal: European Respiratory Journal (2006)

example, country-wide epidemics and the increasing seroprevalence of Chlamydia pneumoniae infection in Finland [4] have been accompanied by corresponding country-wide increased asthma medication use in both males and females and all age groups [5].The growing body of clinical, epidemiological and therapeutic evidence implicating acute, reactivated and chronic infection by C. pneumoniae in asthma [6,7] forms the basis for proposing the theory that a now waning, geographically heterogeneous worldwide C. pneumoniae pandemic is responsible for the recent unexplained observations.According to this theory, genetic susceptibility involves polymorphisms influencing innate/adaptive immunity and other critical functions (e.g.attachment receptors, etc.) that affect host response to C. pneumoniae infection to promote asthma and lung remodelling.As an example, in a case-control study, NAGY et al. [8] reported a strong and significant interaction between C. pneumoniae immunoglobulin A antibody, a putative marker for chronic infection, and mannosebinding lectin (MBL) allele polymorphisms producing MBL deficiency in children with asthma.C. pneumoniae has been detected in more than half of bronchoalveolar lavage fluids of another group of asthmatic children [9], confirming that the organism is actually present.MBL deficiencies affect up to one quarter of human populations and, perhaps not coincidentally, 20-25% is the apparent ''upper limit'' of wheezing prevalence in epidemiological studies.Acute primary C. pneumoniae infections have been documented to trigger new-onset asthma, which can be successfully rendered asymptomatic after antibiotic treatment [10], raising the possibility of early detection and prevention.Asthma is a strong risk factor for developing chronic obstructive pulmonary disease (COPD) [11] and chronic C. pneumoniae infection is also implicated in COPD [12], further suggesting the possibility of prevention of COPD by early recognition and treatment.The Chlamydia-asthma theory is receiving growing attention among a segment of the public that is acutely aware of current limitations in asthma treatment (www.asthmastory.com).I suggest that now is the time for asthma researchers to promote the widespread critical evaluation that the Chlamydia-asthma theory deserves.
Dunn's Pure Food and Drug Legal Manual
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ENDOMETRIOSIS AND MALIGNANCY
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Portuguese Society of Digestive Endoscopy (SPED)www.sped.pt
Journal: Endoscopy (2018)

The Portuguese Society of Digestive Endoscopy (SPED) established Education as one of its main ideological purposes, and it has been assured by the Education Committee of SPED along the years. As expected, the focus of this committee is being the development and monitoring of training activities in the field of Digestive Endoscopy.
Diabetic retinopathy.
Authors: E M Kohner
Journal: BMJ (1993)

The disease must appear in a defined population * The population must be identifiable * The disease must present a health problem * There must be an effective treatment for the disease * Screening must be cost effective in financial terms and concerning quality of lifeScreening should be yearly33 for patients with insulin dependent or non-insulin dependent diabetes.There is no evidence that less frequent screening will suffice or would be easier to carry out.It is possible that good control of blood glucose, adequate screening, and early treatment will reduce blindness related to diabetes.It is hoped that further research will identify the pathogenic steps and that this will lead to more effective forms of treatment so that in future no one with diabetes will have to lose vision.
Diphenylhydantoin and Insulin-Secreting Tumors
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elements of Histology.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neoplasms of the Urinary Bladder and Liver in Rats Fed 2-Acetylaminofluorene and Indole
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 751: Integrated Genetic Linkage Analysis and Expression Profiling in the Rat Heart to Identify Primary Drivers of Cardiac Hypertrophy
Authors: Rizwan Sarwar, Enrico Petretto, Han Lu, Blanche Schroen, Mande K Kumaran, Ian C Grieve, Judith Fischer, Norbert Hubner, Jonathan Mangion, Yigal M Pinto, Michal Pravenec, Timothy J Aitman, Stuart A Cook
Journal: Circulation (2007)

Intro: Although up to 60% of left ventricular mass (LVM) can be accounted for by extra-cardiac factors, the cause of remaining variance is uncharacterised. Hypothesis: Cardiac gene expression is under genetic control and these genetic effects account, at least in part, for the uncharacterised component of LVM. Method: We combined genetic linkage analysis with genome-wide expression profiling in a recombinant inbred (RI) rat strain panel to map the genetic determinants of cardiac gene expression, taking into account naturally occurring variation in blood pressure. Cardiac gene expression in 29 RI strains was quantified with 128 Affymetrix 230 2.0 microarrays, and linkage analysis of gene expression was performed with correction for multiple testing. Candidate genes for LVM were defined as gene colocalised with regions of the rat genome previously associated with LVM. Candidate genes identified in the rat were prioritised by assessing whether their human orthologues were dynamically regulated in heart biopsies from patients with cardiac hypertrophy undergoing surgery for aortic stenosis ( n =20) as compared to controls ( n =7), as determined with Affymetrix U133 microarrays. Results: We showed that genetic regulation of cardiac transcription is predominant when compared to extra-cardiac effects. This enabled us to determine the major control points of cardiac gene expression in the rat ( n =3,744, genome-wide P &lt;0.05). A subset of 50 genes that mapped to themselves and colocalised with regions of the rat genome known to regulate LVM were identified. One of these 50 rat genes was mimecan or osteoglycin precursor ( Ogn ), whose orthologue showed the highest correlation with LVM out of the 22,284 probesets used in the human microarray analysis ( r =0.62, P =0.0008). We went on to refine the rat QTL associated with Ogn (peak LOD 4), and identified sequence variations that might be causative. We then showed that cardiac protein levels of OGN are increased in both rat and human hypertrophy. Conc: Combined linkage and expression studies provide a new and powerful systems approach to dissecting the pathophysiology of genetically complex traits. These data implicate Ogn as a primary genetic driver and biomarker of cardiac hypertrophy and warrant further functional testing.
Intranasal Lidocaine for Treatment of Migraine
Authors: Amir Tulchinsky
Journal: JAMA (1996)

<h3>To the Editor.</h3> —I am concerned that the study by Dr Maizels et al<sup>,</sup>which shows efficacy for intranasal lidocaine in the treatment of migraine headaches, is a demonstration of the ability of therapy to show a positive response rate when the treatment and placebo are not equivalent. This is an important issue regarding this double-blind randomized controlled study, because intranasal lidocaine is highly irritative and can easily be distinguished from the relatively benign and comfortable instillation of saline that was used as a control. It is reasonable to expect that the treatment that causes more irritation might cause a higher placebo response rate, as has been demonstrated in several reviews of placebo pharmacology.<sup>3,4</sup>Patients tend to perceive larger capsules of placebo as being stronger than smaller ones, 2 placebo capsules as producing stronger effects than just 1,<sup>2</sup>and injections as producing larger placebo effects than pills.<sup>3,4</sup> The literature on
Misleading Ga-67-Tc-99m Colloid Subtraction Liver Scintigraphy in a Patient with Pheochromocytoma
Authors: CHRISTIAN MÜLLER, WALTER KLEPETKO, HELMUT SINZINGER
Journal: Clinical Nuclear Medicine (1990)

MÜLLER, CHRISTIAN M.D*; KLEPETKO, WALTER M.D.†; SINZINGER, HELMUT M.D.‡ Author Information