tbuckley/cabot-search huggingface dataset:
The Macroglobulins
Authors: Fred S. Rosen
Journal: New England Journal of Medicine (1962)

WHEN normal human serum is subjected to the gravitational force of ultracentrifugation the nonlipid-bearing proteins separate into three major components. The three components were at first identified as the A, G and M peaks. The A component, which contains the largest amount of protein, sediments most slowly; it consists mostly of albumin whence the designation "A". The G component is intermediate in size and rate of sedimentation; it is almost entirely gamma globulin and was thus designated "G". The smallest of the three peaks sediments with great rapidity because the protein molecules of which it is composed have a molecular . . .
Alteration of BIRC3 and Multiple Other NF-κB Pathway Genes in Splenic Marginal Zone Lymphoma
Authors: Davide Rossi, Silvia Deaglio, David Dominguez-Sola, Silvia Rasi, Tiziana Vaisitti, Claudio Agostinelli, Valeria Spina, Alessio Bruscaggin, Sara Monti, Michaela Cerri, Stefania Cresta, Marco Fangazio, Luca Arcaini, Marco Lucioni, Roberto Marasca, Catherine Thieblemont, Daniela Capello, Fabio Facchetti, Ivo Kwee, Stefano A. Pileri, Robin Foà, Francesco Bertoni, Riccardo Dalla-Favera, Laura Pasqualucci, Gianluca Gaidano
Journal: Blood (2011)
Chemosensitivity and endocrine sensitivity predicted by mammaprint and blueprint in the Neoadjuvant Breast Registry Symphony Trial (NBRST).
Authors: Pat W. Whitworth, Mark Gittleman, Stephanie Akbari, Lisette Stork, Femke De Snoo, Jessica Gibson, Peter D. Beitsch
Journal: Journal of Clinical Oncology (2014)

1078 Background: Classification into molecular subtypes is important for the selection of therapy for patients with breast cancer. Previous analyses demonstrated that breast cancer subtypes have distinct clinical outcome (Gluck, BCRT 2013). The aim of the prospective NBRST study is to measure chemosensitivity as defined by pathological Complete Response (pCR), or endocrine sensitivity as defined by partial response (PR) and metastasis-free survival in molecular subgroups. Methods: The study includes women aged 18-90 with histologically proven breast cancer, who are scheduled to start neo-adjuvant chemotherapy (NCT) or neo-adjuvant endocrine therapy (NET), and who provide written informed consent. Additional inclusion criteria include no excision biopsy or axillary dissection, no confirmed distant metastatic disease, and no prior therapy for breast cancer. Treatment is at the discretion of the physician adhering to NCCN approved regimens. Results: 336 Patients, T1-4 N0-3, had definitive surgery and the overall pCR rate was 24%. 32/167 (19%) IHC/FISH ERPR+/HER2- patients were re-classified by BluePrint (31 Basal). 43/95 (45%) IHC/FISH HER2+ patients were re-classified by BluePrint (25 Luminal and 18 Basal). 3/74 (3%) IHC/FISH triple negative patients were not Basal by BluePrint. Of 45 (13%) patients classified as Luminal A 32 received NCT; 1 patient (3%) had a pCR; 13 patients received NET and 9 (70%) had a PR. Of 116 (35%) patients classified as Luminal B 111 received NCT and 7 (6%) had a pCR. The pCR rate (17/149 (11%)) in IHC/FISH ERPR+/HER2- patients was higher. 55 (16%) are BluePrint HER2 and received NCT (51 plus trastuzumab); 27 (49%) had a pCR compared to 35/95 (37%) in IHC/FISH HER2+ patients. 120 (36%) are BluePrint Basal and received NCT; 46 (38%) had a pCR, similar to the pCR percentage seen in the 74 patients designated triple-negative by IHC/FISH. Conclusions: Molecular subtyping using MammaPrint and BluePrint leads to a reclassification of 23% (78/336) of tumors. BluePrint reclassification resulted in better grouping of patients into expected response groups compared to local surrogate subtyping with immunostains. Clinical trial information: NCT014799101.
Received
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Specialist Qualifications
Authors: W. T. Irvine
Journal: BMJ (1964)

<h3>Objective.</h3> Cardiac involvement means a poor prognosis in systemic sclerosis (SSc). Conduction defects and arrhythmias are frequent in patients with SSc, and may result in sudden cardiac death. We tested whether electrophysiologic studies and implantation of cardioverter defibrillators are recommended when ventricular arrhythmias are present. <h3>Method.</h3> A cardioverter defibrillator was implanted in 10 patients with SSc who had heart involvement. <h3>Result.</h3> After 36 months, analysis of the device showed several episodes of ventricular tachycardia in 3 patients, which were promptly reverted by electrical shock delivery. <h3>Conclusion.</h3> In patients with SSc who are affected by ventricular arrhythmias, the implantation of a cardioverter defibrillator may prevent sudden cardiac death.
AMA-RPS Heard in the House of Delegates
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply:
Authors: Albert Parés, Llorenç Caballería
Journal: Hepatology (2010)

We really appreciate the comments by Macaron et al. Indeed, the information that they have provided confirms the reported results indicating that the incidence of hepatocellular carcinoma (HCC) in patients with stage IV primary biliary cirrhosis (PBC) is approximately 1.5 to 1.8 cases per 100 person-years.1, 2 The commentary on the differences in the incidence of HCC in patients with advanced PBC and in patients with hepatitis C virus (HCV)–related cirrhosis should, however, be considered cautiously, particularly because some bias may have been incorporated into Macaron et al.'s analysis on account of factors such as the shorter period of follow-up (median = 3.6 years) and the lack of accurate information on the clinical characteristics and duration of cirrhosis in HCV-infected patients. Thus, the reported incidence of HCC in these latter patients with HCV cirrhosis is approximately 20% within a median of 3.6 years, whereas in most series assessed for longer periods, the incidence of HCC in patients with compensated HCV cirrhosis ranges from 4% to 7%.2, 3 In the recently published Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis study, the 5-year incidence of HCC was 7% for patients with cirrhosis.4 Among other factors, the shorter follow-up period in Macaron et al.'s analysis may explain the alleged differences between the two studies. Thus, in our study with a mean follow-up of 6.2 years, the cumulative incidence of HCC in patients with advanced PBC during the first 7 years was very low, but it then became similar to the incidence of HCC in an age-matched and sex-matched group of patients with HCV cirrhosis.2 A comparable trend was observed in Macaron et al.'s analysis, but there was only 15 months of follow-up (see Figure in Macaron et al.'s letter). Likewise, we would like to make a comment on the potential influence of treatments delaying the progression and severity of liver damage, such as antiviral therapy in patients with HCV-related cirrhosis and ursodeoxycholic acid in patients with PBC. Certainly, in a cohort of 389 patients with PBC followed for an average of 9.5 years, the probability of HCC development was significantly reduced for those patients receiving ursodeoxycholic acid therapy.5 Albert Parés M.D.*, Llorenç Caballería M.D.*, * Liver Unit, Hospital Clinic, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red en Enfermedades, Hepáticas y Digestivas (CIBERehd), University of Barcelona, Barcelona, Spain.
Injuries among wrestlers in school and college tournaments
Authors: R. H. Strauss
Journal: JAMA (1982)

We studied four wrestling tournaments that totaled 1,049 participants of grade school, high school, and college age levels. Two clearly serious injuries occurred: a wrist fracture and an elbow dislocation. Knee and ankle sprains of mild to moderate severity were the most common diagnoses. No injuries to the pinna occurred probably because ear protectors were worn. Nine- to 14-year-old boys were injured least frequently (3.8%), partly because their matches were the shortest. The overall injury rate for high school and college wrestlers was 12.0%. Risk of injury did not vary with weight class or with successive matches. Thirty-nine percent of all injuries were because of aggravation of old injuries. Thus, rehabilitation after injury is believed to be an important preventive measure. These findings suggest that, although most injuries in wrestling are not severe, attendance at tournaments by medically trained personnel is warranted. (<i>JAMA</i>1982;248:2016-2019)
Cardiopulmonary resuscitation
Authors: C M Byatt
Journal: BMJ (1994)

patients with recurrent unexplained falls and syncope, and 82% of this group benefit from intervention.2Simple faints are uncommon in elderly people, partly because of their altered baroreflex sensitivity.Treatment with a vasodilator is the commonest cause of vasovagal syncope, and symptoms may be modified or abolished by a change in treatment.If carotid sinus massage produces an important reproducible asystolic response this is not normal5 and in symptomatic patients requires physiological pacing to abort recurrent syMptoms.4Slowing of the heart rate of greater than 3 seconds during carotid sinus massage does not occur in asymptomatic elderly people.5The carotid sinus syndrome is an underdiagnosed cause of dizziness, falls, and syncope,3 and cardiac pacing will abort syncopal episodes in most cases, although dizziness may persist because ofpersistent hypotensive features.4
Daily concurrent preoperative chemoradiotherapy with docetaxel (D) and cisplatin (C) using new superselective intra-arterial infusion via superficial temporal artery for stage III, IV head and neck cancer
Authors: I. Tohnai, K. Mitsudo, T. Shigetomi, T. Fukui, N. Yamamoto, M. Ueda, N. Fuwa
Journal: Journal of Clinical Oncology (2004)

5529 Background: Combined radiotherapy and intra-arterial chemotherapy for head and neck cancer is currently performed using the Seldinger method. However, chemotherapy and radiotherapy cannot be performed simultaneously on a daily basis because long-term catheterization is not possible. Therefore, we developed a new method based on superselective intra-arterial infusion via the superficial temporal artery and preoperatively performed daily concurrent radiotherapy and chemotherapy with D and C using this method for stage III, IV head and neck cancer. Methods: Thirty-eight patients with stage III, IV oral cancer were treated. The new catheter was prepared by modifying an angiographic catheter measuring (1.35 mm) in diameter. It was inserted superselectively to the feeding artery of the tumor via the superficial temporal artery using a guide wire. Long-term catheterization is possible using this method. Radiotherapy (total dose: 40 Gy) and superselective intra-arterial infusion chemotherapy using D (total dose: 60 mg/m2) and C (total dose: 100 mg/m2) were performed concurrently daily, followed by surgery. Results: Intra-arterial infusion was successful in 35 patients, but unsuccessful in 3 patients due to arterial anomalies. Grade 3 toxicities were noted for leukopenia (6.5%), thrombocytopenia (3.2%), mucositis (12.9%), and dermatitis (6.5%). No infection was observed during catheterizaition, and no major complications were observed. The clinical efficacy was CR in 28 (80.0 %) patients and PR in 7 (20.0 %), and histopathology of the resected tumors indicated pathological CR in 31 (88.6 %), and pathological PR in 4 (11.4 %). The 4-year cumulative survival rate was 82.9 %. This survival rate is higher than the rate of conventional therapy. Conclusions: This superselective intra-arterial infusion allows for long-term catheterization, unlike the Seldinger method, so that chemotherapy can be performed simultaneously with radiotherapy. This method promises to be the strategy of choice for the treatment of stage III, IV head and neck cancer. No significant financial relationships to disclose.
Errors in Response Rate, Effect Sizes, and Confidence Intervals
Authors: Alan Davis, Roland Griffiths
Journal: JAMA Psychiatry (2021)

Alan K. Davis, PhD; Frederick S. Barrett, PhD; Darrick G. May, MD; Mary P. Cosimano, MSW; Nathan D. Sepeda, BS; Matthew W. Johnson, PhD; Patrick H. Finan, PhD; Roland R. Griffiths, PhD
Current Concepts in Psycho-Oncology and AIDS
Journal: JNCI Journal of the National Cancer Institute (1987)

Journal Article Current Concepts in Psycho-Oncology and AIDS Get access JNCI: Journal of the National Cancer Institute, Volume 79, Issue 1, July 1987, Page 197, https://doi.org/10.1093/jnci/79.1.197-b Published: 01 July 1987
A New Implant Material for Use in Reconstructive Surgical Procedures
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcomes of surveillance VS. adjuvant chemotherapy for patients with STAGE IA and IB NON-seminomatous testicular germ-cell tumors.
Authors: Ahmet Bilici, Mahmut Gumus, Hatice Odabas, Nurten Kandemir, Umut Demirci, Sener Cihan, Ibrahim Vedat Bayoglu, Bala Basak Oven Ustaalioglu, Turkan Ozturk, Esma Turkmen, Zuhat Urakci, Mehmet Metin Seker, Yusuf Gunaydin, Fatih Selcukbiricik, Nedim Turan, Alper Sevinc
Journal: Journal of Clinical Oncology (2016)

e16051 Background: Approximately 50-60% of nonseminomatous germ-cell tumors (NSGCT) present with clinical stage I (CS I). Initial active surveillance, adjuvant chemotherapy and retroperitoneal lymph node dissection (RPLND) are acceptable three treatment options for these patients, but there is no uniform consensus. In this study, outcomes of active surveillance and adjuvant chemotherapy were compared in CS I NSGCT. Methods: A total of 201 patients with CS I NSGCT after orchiectomy in Turkey were included. Outcomes of active surveillance and adjuvant chemotherapy were retrospectively analyzed. The prognostic factors and the factors predicting relapse were evaluated. Results: Of the 201 patients, 110 (54.7) received adjuvant chemotherapy, while the remaining 91 patients (45.3%) underwent surveillance. Relapses were significantly higher for patients underwent surveillance compared to adjuvant chemotherapy group (18.3% vs. 1.2%, p < 0.001). The five-year disease-free survival (DFS) rate for patients who were treated with adjuvant chemotherapy were significantly better than surveillance group (97.6% vs. 80.8%, respectively; p < 0.001), but overall survival (OS) rates were similar. Univariate analysis showed that the presence of vascular invasion and treatment option for DFS and pT stage, invasion of rete testis, and the presence of relapse for OS were significant prognostic factors. Multivariate analysis revealed that the treatment strategy was an independent prognostic factor for DFS (p < 0.001). A logistic regression analysis demonstrated that treatment options (p = 0.031), EC > %50 (p = 0.013) and tumor diameter (p = 0.016) were found to be an independent factor for predicting relapse. Conclusions: Our results indicate that adjuvant chemotherapy is associated with improved DFS compared with surveillance for CS I NSGCT. The treatment strategy is an important prognostic indicator for DFS and a predictive factor for relapse. Although adjuvant chemotherapy seems to be a suitable treatment for patients with risk factors for relapse, surveillance is still feasible management option. More reliable predictive factors are needed to make treatment decisions.
STUDENTS AGAINST PROGRESS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dislocation of the cervical spine without spinal cord injury
Authors: E. G. Bovill
Journal: JAMA (1971)

Dr. Day: A 27-year-old man fell backward down a 40-foot cliff, but did not lose consciousness. His only complaints were of stiffness in the neck, pain in the interscapular area, and tingling in the fingers of the left hand in the distribution of the radial nerve, and in the lateral aspect of the left foot. Past history was noncontributory. Physical examination revealed an oriented and alert male in some distress, with his head held rigidly in slightly flexed position and with a 4-inch laceration over the left frontal area. Vital signs were normal. Neurological examination demonstrated normal function except for hyperactive reflexes in the lower extremities. Tenderness was noted over the cervical and dorsal spine. X-ray examination revealed anterior dislocation of C-5 and C-6 with questionable compression fracture of the anterior border of the body of C-6, and avulsion fracture of the spinous process of C-5 (Fig 1). He was
Accidental intra-arterial injection of penicillin G. A preventable catastrophe
Authors: H. Schanzer
Journal: JAMA (1979)

WHEN administered by the intraarterial route, many drugs induce lesions in the small arterioles, resulting in thrombosis and ischemic damage to tissues supplied by them.<sup>1-7</sup>Intra-arterial injection of penicillin has been reported to induce damage by this same mechanism.<sup>8-11</sup> This communication refers to two cases of accidental intra-arterial injection of penicillin. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 10-month-old infant was brought to the emergency room of Mt Sinai Hospital, New York, with a two-day history of fever and pain in the right ear. On examination, a purulent right otitis media was found and a mixture of penicillin G benzathine and penicillin G procaine (Bicillin C-R), 1,200,000 units, was administered in the upper third of the external aspect of the left thigh. Immediately after injection, the child became very irritable; four hours later, the mother noticed marked swelling of the left inferior extremity. In the emergency room, the swelling
ACROMEGALY.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal