tbuckley/cabot-search huggingface dataset:
Leads from the MMWR. Update: prevention of Haemophilus influenzae type b disease
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Title
Authors: Rebecca Gooch, Jeremy Kahn
Journal: JAMA (2014)

In Reply We did not argue that ICU admission directly harms patients with low illness severity.Our Viewpoint acknowledged a small potential benefit of close observation in the ICU for these patients.Therefore, we did not use the term supplierinduced demand, which, as Mr Friedman correctly notes, implies but does not require a lack of marginal benefit. 1 Instead, we argued that this small potential benefit does not justify the high costs of building and maintaining ICUs.The idea that excess ICU bed supply leads to overuse is well supported by data, both old 2 and new. 3 Friedman's suggestion that current use patterns represent an efficient use of resources lacks the same evidentiary support.Moreover, although it is true that ICU beds carry high fixed costs, and therefore the costs to individual patients are low, we did not propose simply not admitting low-risk patients.We proposed closing ICU beds and thus, substantially lowering fixed costs.Friedman's alternative solution of varying ICU prices based on appropriateness is intriguing but impractical.It would require accurate and reliable assessment of ICU appropriateness, which is currently impossible 4 ; and it would lead to explicit rationing by ability to pay, which is ethically untenable. 5 Our solution is to trust the innate ability of physicians to perform safe implicit rationing in the setting of constrained supply, 6 maintaining quality while reducing the costs of care.
Reply
Authors: Mark L. Heaney, Jeffrey R. Gardner, Owen A. O'Connor
Journal: Cancer Research (2009)

In Response:We thank Dr. Espey and his colleagues for their interest in our article. We believe, however, that their concern about the use of dehydroascorbic acid (DHA) as the form of vitamin C used to test the hypothesis that increased intracellular concentrations of ascorbate might attenuate the therapeutic effects of antineoplastic agents is misdirected. We used DHA as the only efficient means to increase intracellular ascorbate in the cell lines that we studied (1–3). In order to maintain continuity, we also used DHA in the in vivo mouse experiments. Although DHA is not the chemical form of vitamin C that can be purchased over the counter, the intracellular ascorbate that we measured is the same chemical moiety that is accumulated intracellularly with oral ascorbic acid supplementation. Although Dr. Espey and his colleagues note that we achieved higher intracellular ascorbate levels with DHA than are routinely achieved with oral vitamin C in our experiments, we believe that it is important to point out that we presented data to show that lower levels of intracellular ascorbate (4-10 mmol/L) also attenuated the cytotoxic effects of all of the antineoplastic agents that we tested. Because we tested a preclinical model, we share the concern that our results not be extrapolated prematurely to a clinical scenario. Nonetheless, intracellular concentrations of ascorbate that mitigate the cytotoxicity of anticancer drugs overlap intracellular concentrations of ascorbate that can be achieved in normal human lymphocytes in healthy subjects taking 1,000 mg of ascorbate daily, and perhaps less (4). We are less convinced that the available data provide reassurance that cancer cells have lower levels of intracellular ascorbate, but wholeheartedly agree that this issue is in need of more study.No potential conflicts of interest were disclosed.
Inhibition of 5-lipoxygenase promotes the regeneration of the liver after partial hepatectomy in normal and icteric rats
Authors: M Urade, R Izumi, H Kitagawa
Journal: Hepatology (1996)

The role of leukotriene (LT) on liver regeneration after hepatectomy is still unknown. LTB 4 stagnates in the liver with obstructive jaundice, because LTB 4 is excreted in the bile; therefore, LTB 4 may have an effect on liver regeneration after hepatectomy with obstructive jaundice. Release of obstructive jaundice and simultaneous 70% hepatectomy was performed in rats to study the effect of 5-lipoxygenase inhibitor (AA-861) on liver regeneration. Group 1 underwent hepatectomy with administration of 0.1 mL dimethyl sulfoxide (DMSO), group 2 underwent hepatectomy with administration of AA-861 (20 mg/kg/d) dissolved in 0.1 mL DMSO, group 3 underwent hepatectomy with administration of AA-861 (40 mg/kg/d) dissolved in 0.1 mL DMSO, group 4 underwent release of obstructive jaundice and hepatectomy with administration of 0.1 mL DMSO, and group 5 underwent relief of obstructive jaundice and hepatectomy with administration of AA-861 (20 mg/kg/d). DMSO or AA-861 was administered 24 hours before, during, and 24 hours after hepatectomy in each group. Whole blood LTB 4 and serum alanine aminotransferase (ALT), total bilirubin, and bromodeoxyuridine labeling index (LI) were measured before and after hepatectomy. The LTB 4 level increased during obstructive jaundice and after hepatectomy. LTB 4 and serum ALT levels were significantly lower after hepatectomy in the rats that were administered AA-861, and a significantly higher LI was observed at 24 hours after hepatectomy in rats receiving AA-861. Inhibition of 5-lipoxygenase promotes liver regeneration and decreases hepatocyte injury after hepatectomy associated with obstructive jaundice.
ten forty
Authors: Christos Theophanous
Journal: Annals of Internal Medicine (2016)

Ad Libitum19 July 2016ten fortyChristos Theophanous, BAChristos Theophanous, BAFrom Keck School of Medicine of the University of Southern California, Los Angeles, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-0810 Audio Reading - “ten forty” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "ten forty," by C. Theophanous. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail she remembers ten fortyas cold leather and fashion magazinesforms and insurance cardspastel landscapes in black framesand the glug-glug filling of Styrofoam cups,before her wrinkles carried tear streamsto dampened tissuesas translators asked for family contactsand hands were placed on shouldersand results read from beige folders,when she still thought of grocery listsand an herb garden of thymeand a bookmarked Lincoln biographyand a faded appointment bookwhose Tuesday reads: doctor's ten forty. Author, Article, and Disclosure InformationAffiliations: From Keck School of Medicine of the University of Southern California, Los Angeles, California.Current Author Address: Christos Theophanous, BA; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “ten forty” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "ten forty," by C. Theophanous. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 19 July 2016Volume 165, Issue 2Page: 152KeywordsRiversShoulders ePublished: 19 July 2016 Issue Published: 19 July 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
NARRATION
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Whither Psychiatry
Authors: Zenonas Danilevicius
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The hypothetical question implying that the need for psychiatry may soon become questionable was naturally posed to needle psychiatrists into action, to start them thinking about how their specialty should be shaped in the future. If I thought that psychiatry was not needed, the editorial would not have been written at all. However, to say that all is well would be to close one's eyes. Lack of direction in psychiatry worries me. My suggestion that psychiatrists should stay in the domain of medicine is based on the deep conviction that this is the only way for this branch of medicine. As I suggested, society, the community, and even politics should be something that the psychiatrist would live within and use as a source for understanding his patient and the patient's milieu. The psychiatrist should not go blindly into community action, but understanding of the community should be
Book Reviews
Journal: British Journal of Dermatology (1991)

British Journal of DermatologyVolume 124, Issue 5 p. 511-511 Book Reviews First published: May 1991 https://doi.org/10.1111/j.1365-2133.1991.tb00645.xCitations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Dermatology. 1st edition. Edited by M.Orkin, H.Maibch and M.V.Dahl Practice of Skin Surgery. P.N.Behl Clinical Dermatology. By J.A.A.Hunter, J.A.Savin and M.V.Dahl Citing Literature Volume124, Issue5May 1991Pages 511-511 RelatedInformation
From the Congressional Office of Technology Assessment
Authors: Judith Wagner
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Visceral Changes in Myotonic Dystrophy.
Authors: Bernard M. Schuman
Journal: Annals of Internal Medicine (1965)

s1 May 1965Visceral Changes in Myotonic Dystrophy.Bernard M. Schuman, M.D., F.A.C.P., Joseph A. Rinaldo Jr., M.D., F.A.C.P., J. Dana Darnley, M.D.Bernard M. Schuman, M.D., F.A.C.P.Search for more papers by this author, Joseph A. Rinaldo Jr., M.D., F.A.C.P.Search for more papers by this author, J. Dana Darnley, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1097_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is not generally appreciated that alteration of the muscular component of viscera can be a dominant feature of myotonic dystrophy. Twelve patients with varying degrees of clinically evident involvement of somatic muscles were studied. Abnormal electromyograms were present in the five patients tested. Dysfunction of striated laryngeal and pharyngeal muscles was a prominent clinical finding. Manometric evaluation of the pharynx and esophagus was carried out in ten patients, six of whom complained of dysphagia. Not only was there a marked weakness of the pharyngeal swallowing contraction in five of eight patients examined, but nine of ten patients had similar... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Bernard M. Schuman, M.D., F.A.C.P.; Joseph A. RinaldoJr., M.D., F.A.C.P.; J. Dana Darnley, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1097-1098KeywordsDysphagiaElectromyographyEsophagusMusclesMyotonic dystrophyPatientsPharynxSwallowing ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
Thirty-First Annual Symposium on Fundamental Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Thirty-First Annual Symposium on Fundamental Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 59, Issue 2, August 1977, Page 543, https://doi.org/10.1093/jnci/59.2.543-e Published: 01 August 1977
Abstract 3526: Medication Non-adherence Is Associated With A Broad Range Of Adverse Outcomes In Patients With Coronary Artery Disease
Authors: P. Michael Ho, David J Magid, Susan M Shetterly, Kari L Olson, Thomas M Maddox, Pamela N Peterson, Frederick A Masoudi, John S Rumsfeld
Journal: Circulation (2007)

Background: Little is known about the effect of non-adherence among coronary artery disease (CAD) patients on a broad spectrum of outcomes including cardiovascular mortality, cardiovascular hospitalizations or revascularization procedures. Methods: This was a retrospective cohort study of 15,767 patients with CAD in a managed care organization. Medication adherence was calculated as proportion of days covered (PDC) for filled prescriptions of β-blockers, ACE-inhibitors, and statin medications. Multivariable Cox regression assessed the association between medication non-adherence as a time-varying covariate and mortality (all-cause and cardiovascular), adjusting for demographics and clinical characteristics. Median follow-up was 4.1 years. Results: Across the three classes of medications, non-adherent patients were more likely to be younger and have a diagnosis of COPD or depression. In unadjusted analysis, non-adherence to each individual class of medication was associated with higher all-cause and cardiovascular mortality. In multivariable analysis, non-adherence remained significantly associated with increased all-cause mortality risk for β-blockers (HR 1.50; 95% CI 1.33–1.71), ACE-inhibitors (HR 1.74; 95% CI 1.52–1.98), and statins (HR 1.85; 95% CI 1.63–2.09). In addition, non-adherence remained significantly associated with higher risk of cardiovascular mortality for β-blockers (HR 1.53; 95% CI 1.16 –2.01), ACE-inhibitors (HR 1.66; 95% CI 1.26 –2.20), and statins (HR 1.62; 95% CI 1.124 –2.13). The findings of increased risk associated with non-adherence were consistent for cardiovascular hospitalization and revascularization procedures. Conclusions: Non-adherence to cardioprotective medications is associated with a broad range of adverse outcomes. These findings support the importance of non-adherence in clinical practice and suggest that medication non-adherence should be a target for future interventions.
Disparities in Screening for and Awareness of High Blood Cholesterol—United States, 1999-2002
Journal: JAMA (2005)

High blood cholesterol is a major modifiable risk factor for atherosclerotic cardiovascular disease. Two national health objectives for 2010 are to reduce to 17% the proportion of adults with high total blood cholesterol levels and to increase to 80% the proportion of adults who had their blood cholesterol checked during the preceding 5 years. In addition, an overall national health objective is to eliminate racial/ethnic and other disparities in all health outcomes. During 1960-1994, total blood cholesterol levels among the overall U.S. population declined; however, levels have changed little since then, despite increases in cholesterol screening and awareness. To assess racial/ethnic and other disparities among persons who were screened for high blood cholesterol during the preceding 5 years and among persons who were aware of their high blood cholesterol, CDC analyzed data from the 1999-2000 and 2001-2002 National Health and Nutrition Examination Surveys (NHANES). This report summarizes the results of that analysis, which indicated that Mexican Americans, blacks, and younger adults were less likely to be screened for high blood cholesterol, and persons in those populations who had high cholesterol were less likely to be aware of their condition. Efforts are needed to encourage persons, especially among these populations, to seek screening and gain awareness of high blood cholesterol.
Role of adenosine receptors in the inhibition of ifbroproliferation due to pentoxifylline and M-1 metabolite . Depts. of Medicine and Pharmacology, Dalhousie University, Halifax, N.S., Canada
Journal: Hepatology (1995)

We have examined the effects of R-phenylisopropyladenosine (R-PIA) and other adenosine analogues on basal, prostaglandin E1 (PGE1)- and forskolin-stimulated cyclic AMP (cAMP) formation in intact N1E-115 neuroblastoma cells, to determine whether the cells contain A1 adenosine receptors that are negatively coupled with adenylate cyclase. Basal levels of cAMP (68 ± 7 pmol/mg protein; mean ± SE, N = 15) were not altered by low concentrations of R-PIA. The apparent lack of inhibition was not due to increases in cAMP due to activation of a stimulatory A2 receptor by endogenously-synthesized adenosine. By comparison, low levels of R-PIA did reduce significantly (P < 0.05) PGE1-dependent increases in cAMP formation (maximum response to PGE1, 972 ± 77 pmol cAMP/mg protein; ec50 for PGE1, 0.2 μM). Inhibition was dose dependent, and resulted in a 30–50% maximum reduction in production stimulated by PGE1. Nanomolar concentrations of R-PIA elicited half-maximal inhibition; the inhibitory response was blocked by 8-phenyltheophylline (8-PT). The order of potencies of several adenosine analogues in eliciting this response suggested that inhibition was mediated by an A1 adenosine receptor. Examination of the effects of R-PIA on forskolin-stimulated cAMP formation yielded several interesting findings. First, stimulation by the diterpene by itself was blocked by both adenosine deaminase (ADA) and 8-PT (40 and 25% inhibition respectively). Low concentrations of R-PIA (< 10−6M) had no effect on forskolin-stimulated cAMP production. At higher levels (⩾ 10−6M) the analogues acted synergistically with the diterpene, to yield cAMP levels that were up to 3-fold higher than the additive effect of the two agents. Potentiation was stereospecific, Ca2+ dependent, and was blocked by 8-PT. The results of this study suggest that, in N1E-115 neuroblastoma cells, inhibitory A1 receptors are not stimulated in response to non-specific elevations in cAMP, but are associated with specific stimulatory receptors such as those activated by PGE1.
Identification of Anovulation and Transient Luteal Function Using a Urinary Pregnanediol-3-Glucuronide Ratio Algorithm
Authors: Amir Kassam, James W. Overstreet, Christine Snow-Harter, Mary Jane De Souza, Ellen B. Gold, Bill L. Lasley
Journal: Environmental Health Perspectives (1996)

The sensitivity and specificity of a urinary pregnanediol-3-glucuronide (PdG) ratio algorithm to identify anovulatory cycles was studied prospectively in two independent populations of women. Urinary hormone data from the first group was used to develop the algorithm, and data from the second group was used for its validation. PdG ratios were calculated by a cycles method in which daily PdG concentrations indexed by creatinine (CR) from cycle day 11 onward were divided by a baseline PdG (average PdG/Cr concentration for cycle days 6-10). In the interval method, daily PdG/CR concentrations from day 1 onward were divided by baseline PdG (lowest 5-day average of PdG/CR values throughout the collection period). Evaluation of the first study population (n = 6) resulted in cycles with PdG ratios > or = 3 for > or = 3 consecutive days being classified as ovulatory; otherwise they were anovulatory. The sensitivity and specificity of the PdG ratio algorithm to identify anovulatory cycles in the second population were 75% and 89.5%, respectively, for all cycles (n = 88); 50% and 88.3% for first cycles (n = 40) using the cycles method; 75% and 92.2%, respectively, for all cycles (n = 89); and 50% and 94.1% for first cycles (n = 40) using the interval method. The "gold standard" for anovulation was weekly serum samples < or = 2 ng/ml progesterone. The sensitivity values for all cycles and for the first cycle using both methods were underestimated because of apparent misclassification of cycles using serum progesterone due to infrequent blood collection. Blood collection more than once a week would have greatly improved the sensitivity and modestly improved the specificity of the algorithm. The PdG ratio algorithm provides an efficient approach for screening urine samples collected in epidemiologic studies of reproductive health in women.