tbuckley/cabot-search huggingface dataset:
Quantitation of Exposure to Benzo[a]pyrene with Monoclonal Antibodies
Authors: Regina M. Santella, Ling-Ling Hsieh, Chen-Dao Lin, Susan Viet, I. Bernard Weinstein
Journal: Environmental Health Perspectives (1985)

It is now possible to quantitate carcinogen adducts on DNA by highly sensitive immunoassays. These techniques are particularly useful for screening human populations for exposure to potential environmental carcinogens. We have developed a panel of monoclonal antibodies that react with benzo(a)pyrene (BP) modified DNA to be used in an enzyme linked immunoassay (ELISA) to quantitate adduct levels of both human and animal samples. BALBc/Cr mice were immunized with either DNA modified by 7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9, 10-tetrahydrobenzo(a)pyrene (BPDE-I-DNA) complexed electrostatically to methylated bovine serum albumin or with BPDE-I-modified guanosine conjugated with bovine serum albumin (BPDE-I-G-BSA). Four stable clones were produced from the spleen cells of animals immunized with BPDE-I-DNA and one from BPDE-I-G-BSA immunized animals. All antibodies were shown to be highly specific for BPDE-I-DNA and did not crossreact with nonmodified DNA or with N-2-acetylaminofluorene or 1-aminopyrene modified DNA. The antibodies differed in their sensitivity to BPDE-II-DNA, BPDE-I-poly G, BPDE-I-tetraols and BPDE-I-dG. In general, all the antibodies showed the greatest affinity for their original antigen. Those generated against modified DNA showed highest reactivity against modified DNA while the one antibody generated against the monoadduct showed highest reactivity with the monoadduct. These antibodies are currently being used in a highly sensitive competitive ELISA to quantitate levels of BP-DNA adducts in various animal and human tissue samples.
Marihuana-induced hospitalization
Authors: G. D. Lundberg
Journal: JAMA (1971)

<h3>To the Editor.—</h3> A study of 701,057 consecutive hospital admissions in Los Angeles from 1961 to 1969 revealed nine instances of marihuana-induced disease requiring hospitalization. Five followed intravenous use, one followed ingestion, and three followed the smoking of marihuana cigarettes. Intravenous injection produced severe disease while the other modes of use resulted in trivial changes. This paucity of recognized disease secondary to marihuana was in sharp contrast to the frequent severe illnesses produced legally by alcohol, tobacco, barbiturates, amphetamines, tranquilizers, and various over-the-counter drugs, and by the illicit opiates and hallucinogens. Major controversy exists regarding the presence and nature of harm associated with marihuana use. To attempt to ascertain the importance of recognized marihuana-induced disease, with the aid of a computer, we searched the records at the Los Angeles County-University of Southern California Medical Center. Of the nine that were secondary to marihuana use, none was fatal (table). Three admissions
American Climates and Resorts.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Hand-Book of Nursing.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE NATIONAL LEPROSARIUM
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toxicity and safety of weekly high-dose 5-FU as 24-h infusion and folinic acid (AIO regimen) in adjuvant therapy of UICC stage III colon cancer. InTACT: A multicenter phase III trial
Authors: A. Wein, T. Lehnert, T. Liersch, D. Braumann, A. Schaible, M. Eckart, R. Thiemann, W. Teichmann, W. Hohenberger, E. G. Hahn
Journal: Journal of Clinical Oncology (2004)

3586 Background: The AIO regimen is common for palliative treatment of colorectal cancer. We report for the first time on the toxicity and safety of the AIO regimen in an adjuvant phase III trial for UICC stage III colon cancer (CC). Methods: A prospective phase III trial based on quality controlled surgery and pathology (QSCP) in UICC stage III CC (R0). Group A: QSCP vs. group B: QSCP+AIO regimen for 6 months. End of trial: 9/01 after interim analysis (Wein et al, Ann Oncol 2002). Trial monitoring: by IMEREM, Nuremberg. In group B chemotherapy was terminated in all 79 patients (pt.). The AIO regimen was administered in the form of a 500 mg / m2 application (appl.) of folinic acid (FA) as 1–2 h i.v., followed by 2000 mg/m2 5-FU as a 24-h i.v. (AIO regimen) via port-a-cath on d 1, 8, 15, 22, 29, 36, qd 57; 3 cycles (6 months). Median follow up: 45.3 months. Results: AIO regimen: n = 79 pt.; m/f: 62%/38%; age: 61 years (28–75). ECOG: 0/1: 71%/29%; Frequent concomitant diseases: arterial hypertension: n=27 (34%); DM: n=12 (15%); glaucoma: n=3 (3,8%); elevated CEA prior to surgery: yes/no/“missing”: 27%/66%/7%. Median start of treatment after surgery: d 29. Total number of 5-FU applications: 1295. The mean 5-FU appl./pt. was 16 (1–18); 18 appl: 77%; > 12 appl. 89% and the mean 5-FU total dose per pt. 32.5 g/m2 (90% of the maximum dosage). As higher grade toxicity grade 3+4 presented: diarrhea: n=7/n=1 (9% / 1.3%); nausea/vomiting: n=3/n=1 (3.8%/1.3%); stomatitis + cheilitis: n=3 /n=1 (3.8% / 1.3%); cardiac toxicity: n=1/n=1 (1.3%/1.3%); no deaths. Thrombosis due to port-a-cath complications: n=3 (3.8%). A dose reduction to 75% was carried out in 2.0% of the appl. and to 50% in 2.9% of the appl., respectively. Conclusions: The AIO regimen is well tolerated in adjuvant chemotherapy treatment of CC. It may be comfortably applied on an outpatient basis and presents a high mean 5-FU dose of 32.5 g/m2 per pt. Compared with 5-FU/FA bolus regimens the AIO regimen appears to offer a more favorable toxicity profile and a higher mean 5-FU dose. For definite conclusions the results of the EORTC (40963) phase III trial remain to be seen. No significant financial relationships to disclose.
Bilateral inguinal adenitis due to a nonphotochromogenic atypical Mycobacterium. Report of a case
Authors: C. L. Andringa
Journal: JAMA (1966)

ATYPICAL, "unclassified" or "anonymous" mycobacteria are a heterogeneous group of microorganisms that are being implicated with increasing frequency as the cause of both symptomatic and asymptomatic infections in children.<sup>1-6</sup>These infections have been associated with cervical<sup>1-4</sup>and axillary adenitis,<sup>1</sup>pulmonary disease,<sup>5</sup>osteomyelitis,<sup>6</sup>superficial granulomas, and disseminated fatal disease.<sup>6</sup>In children, the most commonly reported illness has been unilateral cervical adenitis.<sup>1,2,4</sup>The present report concerns a child with bilateral inguinal adenitis due to a nonphotochromogenic atypical mycobacterium. <h3>Report of a Case</h3> A 5-year-old white girl was admitted to Madison (Wis) General Hospital on Jan 4, 1966, because of bilateral inguinal swelling. Four weeks prior to admission the onset of vaginal discharge and labial pruritis was noted. This persisted until admission in spite of sitz baths and frequent washing. Two weeks prior to admission right inguinal erythema was noted. During the next week this area became
Abstracts for the Society of Nuclear Medicine and Molecular Imaging, Greater New York and New England Chapters, 32nd Annual Northeast Regional Scientific Meeting, Newport, RI
Journal: Clinical Nuclear Medicine (2019)

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A Novel Approach to TB Eradication
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1873: Water-pipe smoking induces epithelial-mesenchymal transition and enhances cell invasion of human breast cancer cells
Authors: Ala-Eddin Al Moustafa
Journal: Cancer Research (2019)

Abstract Water-pipe smoking (WPS) has been recently recognized as an emerging risk factor for human health. The exact role of WPS in human breast cancer development and progression has not been investigated yet. We herein explored for the first time the impact of WPS on epithelial-mesenchymal transition (EMT) and cell invasion, which are considered crucial for cancer progression and metastasis in human carcinomas including breast. Our data revealed that WPS can initiate EMT in two human breast cancer cell lines, MCF-7 and BT20. WPS enhanced the cell invasion ability of both cell lines compared with their matched controls. We also found that WPS provoke a down- and up-regulation of two important regulator genes of cancer progression: E-cadherin and focal adhesion kinase (FAK). In addition, our data pointed out that WPS induces the activation of Erk1/Erk2 signaling pathways, which could be behind the stimulation of EMT and deregulation of E-cadherin and FAKgenes. Taken together, our results imply the significant effects of WPS on several cellular processes and genes involved in breast cancer progression and metastasis. Further studies are necessary to identify the clinical relevance and exact role of WPS in human carcinogenesis and metastasis. Key words: Water-pipe smoking, breast cancer, EMT, cell invasion, cell adhesion Citation Format: Ala-Eddin Al Moustafa. Water-pipe smoking induces epithelial-mesenchymal transition and enhances cell invasion of human breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1873.
Deep sea microbes and DNA cloning.
Journal: Environmental Health Perspectives (1996)

Forumnoses of symptoms, signs, and ill-defined conditions.Joint pain, osteoarthrosis, and backache were the most common diagnoses among those of musculoskeletal and connective tissue diseases.According to the report, "to date, there is not clinical evidence for a previously unknown, serious illness or 'syndrome' among Persian Gulf veterans participating in the study.A unique illness or syndrome ...
Imatinib (STI571) plus hydroxyurea: Safety and efficacy in pre-treated, progressive glioblastoma multiforme (GBM) patients (pts)
Authors: G. Dresemann
Journal: Journal of Clinical Oncology (2004)

1550 Background: Imatinib (I) is a tyrosine kinase inhibitor of Bcr-Abl, platelet-derived growth factor receptors (PDGF-Rs) and the Kit receptor, with remarkable clinical efficacy in chronic myeloid leukaemia and gastrointestinal stromal tumours (GIST). Many malignancies of the brain including GBM express these receptors, yet preliminary results of previous studies have shown a low response rate when used as single agent therapy. Hydroxyurea (H) freely penetrates the brain and cerebrospinal fluid (CSF), and in fact may modulate the blood-brain barrier to facilitate uptake of other drugs. For this reason, we suggested that the combination H with I could potentiate it's activity in GBM. Methods: From June 2001 to November 2003, an exploration of combination therapy with H plus I in 26 GBM pts refractory to multiple prior therapies, including radiation therapy and chemotherapy containing ACNU and temozolomide, was started. Pts were treated with I (400 mg) and H (1000 mg) as continuous daily, oral dosing and followed by clinical examination and magnetic resonance imaging (MRI) every 6 weeks. Results: Fourteen patients are currently evaluable for safety and efficacy. ECOG-performance status at the start of therapy was 1–2, the median age was 40 yrs (31–68), and WHO classification of tumours IV only. Results after a median treatment period of 29 weeks (4–104) were one complete response (CR) lasting 12 months, 4 partial responses (PR) lasting a median of 8 months (1–24), 4 stable disease (SD) for a median of 12 months (3–23) and 5 progressive disease (PD). There were no grade 3 or 4 toxicities. Twelve deaths occurred, 1 pt with PR and 1 pt with SD died of pulmonary embolism, and 10 pts died of PD. The median progression free survival (PFS) was 29 weeks and median overall survival (OS) was 37 weeks. Two pts remain alive without progression for 16 and 24 months, respectively. Conclusions: In summary, combination therapy with I and H was well tolerated and effective in this group of recurrent, refractory GBM pts, with a response rate of 36% and a PFS greater than 6 months. Based on these results, a Phase II study with I plus H in GBM has been started. No significant financial relationships to disclose.
Postspinal Headache
Authors: Elliot Liff
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The Brief Report by Cass and Edelist (227:786, 1974) reminded me of a successful treatment that I came across when suffering from the malady myself several years ago. In their article no reference was made to the remedy I will describe, nor have I been able to find it in the standard neurologic texts. Recall that when a spinal tap is performed, the patient assumes a "fetal position," and with the needle in place a high intraspinal pressure is recorded on the manometer. As the patient straightens his body, the intraspinal pressure drops, and it is generally at this time that the manometer pressure reading is taken, which is, of course, lower. One of the characteristic features of postspinal headache is that it is worse on arising in the morning and may improve as the day goes on. This generally has been attributed to dehydration occurring overnight
Boards of Examiners in the Basic Sciences
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatitis B and C virus infection, alcohol drinking, and hepatocellular carcinoma: A case-control study in Italy
Authors: F Donato
Journal: Hepatology (1997)

We performed a case-control study to assess the association of hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and alcohol drinking. We recruited as cases 172 subjects with an initial diagnosis of HCC, who were admitted to the two major hospitals in the province of Brescia, northern Italy, and 332 subjects, sex-, age-, and hospital-matched, who were admitted to the Departments of Ophthalmology, Dermatology, Urology, Cardiology, and Internal Medicine, as controls. Of the HCC cases, 23.8% were positive for HBsAg and 37.8% for HCV RNA; among the controls, 5.4% were positive for HBsAg and 4.8% for HCV RNA. History of heavy alcohol intake (>80 g of ethanol per day for at least 5 years) was found among 58.1% of the cases and among 36.4% of the controls. The relative risks (RRs) for HBsAg, HCV RNA positivity, and heavy alcohol intake were, respectively: 11.4 (95% confidence interval: 5.7-22.8), 23.2 (95% confidence interval: 11.8-45.7), and 4.6 (95% confidence interval: 2.7- 7.8). Positive interactions (synergisms) between both HBsAg positivity and HCV RNA positivity and heavy alcohol intake were found, suggesting more than additive effects of viral infections and alcohol drinking on the risk of HCC. Infection with HCV genotype 1b showed a higher risk than type 2 (RR = 2.9; 95% confidence interval: 0.9-10), suggesting a major role for the former type in causing HCC. On the basis of population attributable risks (AR), heavy alcohol intake seems to be the single most relevant cause of HCC in this area (AR: 45%), followed by HCV (AR: 36%), and HBV (AR: 22%) infection.
Confidentiality and life insurance.
Authors: T M Pickard
Journal: BMJ (1977)

Reptilase test in cirrhosis and hepatocellular carcinoma SIR,-I read with interest the report by Dr P J Johnson and others (1 October, p 869) of their experience with the reptilase test in patients with various liver diseases, in which these authors contrasted their data with those which I had recorded in a group of Africans with primary liver cancer.tPursuing the latter studies on a group of British patients I became aware of striking differences, particularly in regard to dysfibrinogenaemia.Unfortunately Dr Johnson and his colleagues do not appear to have evaluated this phenomenon.In my experience the reptilase test has been con- sistently abnormal in British and African patients with primary liver cancer, with and without coexistent cirrhosis, in contrast to the normal results obtained in patients with carcinoma metastatic to the liver.However, the corresponding information in cirrhosis un- complicated by tumour does indicate that many of these patients do have an abnormal reptilase test in the absence of dysfibrinogenaemia.These data have been presented on a number of occasions,2 X and a detailed account is to appear shortly.5It includes a description of the modified reptilase test and a putative explanation for the racial differences and the apparently discrepant findings in cirrhosis.