tbuckley/cabot-search huggingface dataset:
Strange Bedfellows
Authors: Walter H. C. Burgdorf, David R. Bickers, Leonard J. Hoenig
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Erratum
Journal: BMJ (1854)

I ie tdhde tubeuw ~~~~~W,a wwith amlrsl _in se glands in thd terie g _ uinmi gEiinp fu was apple on hee S, bt the chlide of zin was deiddy more ga_in.0. Septeber 1*, a ye after the frst applica.t, b ehiride of me was tried for the twentieth time, and the to the extent of thr incbes was destroyed; a part of tW -caeis exilted.Two yeas have now elapsed, and t had been no tendency to reproduetion Dr. Gi8rPTsnx _tthe case inteeting, as it was just such a one which in.asasicmafWY va ted by some quak as a victory gained over in surey, and this one oertainly explained their so-called cu-a and at the same time was frught with caution to the sogen not to lose an opportunity of giving similar cases a trial th the causti before dooming them irrevocably to the knife.Ptofessor Mr referred to cass of soft cancer of the bat where a cure w somatimes obtained by the disewqed productsloghing en mase.He could corroborate the state.ment of Dr. Gillespie with reference to the efficiency of the chloride of zinc; as a caustic it was thorough, and easily kept Eader command.
Corrigendum
Journal: BMJ (1941)

Those who are iilterested in the Near East and in medical ilnternational work are invited to the forty-second annual miieeting of the Lebanon Hospital for Mental Diseases, Syria, on Thursday, June 5, at 4.15 p.m., in the garden lounge of the Westway Hotel, Endsleigh Street, London, W.C. The speakers include Mrs
Efficacy of screening donors for antibodies to the hepatitis C virus to prevent transfusion-associated hepatitis: Final report of a prospective trial*1
Authors: A GONZALEZ
Journal: Hepatology (1995)

Routine screening of blood donors for anti-hepatitis C virus (HCV) has been implemented in most developed countries. However, the independent efficacy of such screening has not been established in a controlled, prospective study. We tracked 478 patients transfused with anti-HCV-negative blood by first-generation enzymelinked immunoassay (EIA) between July 1989 and May 1990 and compared the incidence of transfusion-associated hepatitis and HCV infections with that found among 280 patients transfused with blood unscreened for anti-HCV during the immediately preceding year. Of the 280 patients who had received transfusions before donors were screened for anti-HCV, 27 (9.6%) developed posttransfusion hepatitis and 1 additional patient seroconverted to anti-HCV without evidence of hepatitis, for a risk of posttransfusion HCV infection of 10.7% (28 of 262 recipients seronegative for anti-HCV before transfusion). Of the 478 patients transfused after July 1989 with blood screened for anti-HCV, only 9 (1.9%) developed posttransfusion hepatitis for a risk reduction of 80%. Seven of the 9 residual cases of hepatitis were caused by HCV (7 of 456 recipients seronegative before transfusion or 1.5%) for a risk reduction of transfusion-associated HCV infection of 86%. In retrospect, an anti-HCV positive donor was detected by second-generation immunoassay in 4 (57%) of the 7 HCV cases from the study cohort and in 19 of the 23 (83%) cases from whom all donor samples were available for testing in the historical cohort. No additional infectious donors were detected by third-generation immunoassay or serum HCV-RNA by polymerase chain reaction. Implementation of donor screening for anti-HCV with a first-generation immunoassay appeared to be independently associated with an 80% and 86% reduction in the risks of transfusion-associated hepatitis and HCV infection, respectively. Screening of donors with second-generation immunoassays might have further reduced the risk by 57%. An additional 0.4% may be at risk of developing non-A, non-B, non-C hepatitis.
Procedure
Authors: Jed Myers
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytokine responses to PPD in primary biliary cirrhosis: Evidence for a defect in CD4+ T-cell response 1. Depts of Medicine1 and Biochemistry and Genetics2, University of Newcastle, Newcastle-upon-Tyne, United Kingdom
Journal: Hepatology (1995)

<dm:abstracts xmlns:dm="http://www.elsevier.com/xml/dm/dtd"><ce:abstract xmlns:ce="http://www.elsevier.com/xml/common/dtd" id="abs0005" view="all" class="author"><ce:section-title id="sect0005">Abstract</ce:section-title><ce:abstract-sec id="abst0005" view="all"><ce:simple-para id="spar0015" view="all">The melanocortin receptor 1 (MC1R) plays an important role in melanogenesis and determining the production ratio of eumelanin and pheomelanin. MC1R is highly polymorphic, and some variants are related to red hair color or freckles. Here, we report the case of a Mongolian boy with red hair and extensive freckles, mainly facial, and harboring multiple MC1R variants as found by whole-exome sequencing (WES). The proband was a 14-year-old boy living in the northwestern part of Mongolia. He developed extensive freckles on his sun-exposed area and showed lighter skin tone in comparison to other family members. He also had reddish hair and eyebrows, and gray to hazel irises. WES and phenotypic analysis for the proband, his mother, and his two brothers revealed that compound heterozygous MC1R variants (p.R142H and p.S172I) were responsible for his freckles and hair color. In Addition, the presence or absence of an eye-color associated variant in OCA2 (p.R419Q) clearly explained their eye color. This report may provide a considerably different phenotypic effect between single-hit MC1R and two-hit MC1R.</ce:simple-para></ce:abstract-sec></ce:abstract></dm:abstracts>
Palliative Surgery
Authors: John C. Gaisford
Journal: JAMA (1972)

Physicians speak glibly about palliative surgery without critical analysis as to whether it truly helps the patient. It is necessary to ascertain why there is such marked disparity in the evaluation of this extremely serious problem. Do physicians really know what palliation means? Do they take enough time to evaluate thoroughly the consequences of treating their patients who are dying of cancer? Do they meticulously weigh the factors that may offer some relief from the inevitable complications associated with dying? Palliation can be defined as reducing the severity of the patient's physical problem without curing him of his disease. Over the years, we have observed many poorly managed cancer problems—gastrostomy performed when the patient had no more than a few days to live, radiotherapy begun for hopeless cancer only because the cancer was visible and growing, chemicals given intra-arterially employed for nonresectable neoplasms which were causing no discomfort to a
PRE-COLUMBIAN LEPROSY.
Authors: ALBERT S. ASHMEAD
Journal: JAMA (1895)

Professor Putnam, of Peabody Museum, Cambridge, Mass., with whom I discussed this subject at some length, is not of opinion that a horror of leprosy in ancient Peru would stand in the way of the burial of leprous representations with their dead. "For," says he, "whatever custom has been transmitted from generations to generations is, in Peru, always kept up, whatever might have been the events and circumstances which might deprive the custom of all meaning. Even if they do not understand the meaning of a rite, they will perform it because their fathers did." Mummies are now found in that country, tied up in sacks, the false head sticking out, tied up separately, just as they were in the distant past. The custom was, and is still, to bury with the dead such objects as might indicate his condition of life, or any peculiarity belonging to him as an
Pleural effusion. A diagnostic dilemma
Authors: D. D. Storey
Journal: JAMA (1976)

The cause of pleural effusion in 108 of 133 patients was determined by laboratory tests and clinical examination; it was indeterminate in 25, even after complete diagnostic evaluation. In 164 diagnostic thoracenteses, 136 cytologic examinations were done; the results were positive for cancer in 20 (15%). Five of 19 patients (26%) with bronchogenic cancer, 13 of 25 (52%) with metastatic cancer of the lung, and two of 20 (10%) with lymphoma had positive results on cytologic examination. Of 143 routine bacterial cultures, only five were positive (3%). Of 103 mycobacterial and 76 fungal cultures, only one was positive in each instance. Despite the high incidence of indeterminate diagnoses, we recommend that only measurement of protein content and cytologic examination be ordered routinely. Our algorithm provides a logical, cost-effective approach to the diagnostic problem of pleural effusion. (<i>JAMA</i>236:2183-2186, 1976)
Table Reporting Alcohol Involvement in Fatal Motor-Vehicle Crashes
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Function Following Reconstruction of Previously Closed Major Pulmonary Artery
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of prostacyclin in hemodynamic alterations in conscious rats with extrahepatic or intrahepatic portal hypertension
Authors: F Oberti
Journal: Hepatology (1993)

Although prostaglandins are thought to be involved in the hyperdynamic circulation of portal hypertension, the role of this substance has not been elucidated. Dose-response curves, the hemodynamic effects of prostacyclin (20 μg/kg) and its inhibitor indomethacin and measurements of plasma and urinary levels of 6-keto-prostaglandin F1α were compared in three groups of six rats each: normal, with portal vein stenosis and with secondary biliary cirrhosis. Plasma and urinary levels of 6-keto-prostaglandin F1α were higher in rats with portal vein stenosis and cirrhotic rats than in normal rats. Dose-response curves showed similar maximal decreases in arterial pressure in the three groups, whereas the maximal increase in portal pressure was less marked in cirrhotic rats than in normal rats and rats with portal vein stenosis. In normal rats, prostacyclin increased cardiac output by 21% and portal pressure by 41%. Similar increases were observed in rats with portal vein stenosis. In contrast, prostacyclin did not affect cardiac output and portal pressure in cirrhotic rats. Indomethacin induced a more marked vasoconstrictive effect in normal rats than in cirrhotic rats. This study shows that prostacyclin plays a role in the hemodynamic alterations in portal hypertension. Moreover, the hyporeactivity observed in cirrhotic rats suggests that prostacyclin plays a major role in the circulatory changes of portal hypertension due to chronic liver disease. (HEPATOLOGY 1993;18:621–627)
CO2 rebreathing during BiPAP ventilatory assistance.
Authors: G T Ferguson, M Gilmartin
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

BiPAP ventilatory assistance can increase minute ventilation and reduce respiratory effort, but does not always reduce PaCO2. We studied the effects of BiPAP ventilatory assistance on PaCO2 and examined specific mechanisms whereby BiPAP ventilatory assistance may not lower PaCO2. BiPAP ventilatory assistance using a non-rebreather valve and volume cycled ventilation at similar settings produced significantly lower PaCO2 than BiPAP ventilatory assistance using a standard exhalation device. The failure of PaCO2 to fall with the standard exhalation device was due to exhalation past the exhalation device into the ventilator tubing, subsequent rebreathing of the exhaled gases, and an increase in dead space ventilation. Use of other fixed-resistance exhalation devices also resulted in exhalation back into the ventilator tubing. Use of a new plateau exhalation device or a non-rebreather valve eliminated CO2 rebreathing and its effect on dead space ventilation. Changing exhalation devices had no significant effect on BiPAP pressure generation or sensing capabilities. Our results indicate that the use of a standard exhalation device during BiPAP ventilatory assistance causes CO2 rebreathing, which can blunt any effect of BiPAP on PaCO2. Use of an appropriate alternative exhalation device can eliminate this problem.
Surgery of the Heart
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract B61: CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
Authors: Yu Zhu, Knolhoff Brett, Meyer Melissa, West Brian, Linehan David, David DeNardo
Journal: Cancer Research (2015)

Abstract The immune system is a promising therapeutic target that can be modulated to improve pancreatic ductal adenocarcinoma (PDAC) patient outcomes. Unfortunately, attempts to use immunotherapeutics as single agents have achieved very limited clinical benefits in PDAC. One major obstacle is the presence of an immunosuppressive tumor microenvironment. Critical drivers of this immunosuppressive microenvironment include tumor-associated macrophages, monocytic myeloid-derived suppressor cells, and immature granulocytes/granulocytic. In addition to instigating immune suppression, these tumor-infiltrating leukocytes can impart resistance to cytotoxic therapies and promote metastatic dissemination. As a consequence, high numbers of these myeloid cells are often associated with early metastatic relapse and poor survival in pancreatic cancer patients. Therefore, approaches that reprogram myeloid responses to potentiate antitumor immunity and/or bolster immunotherapy could hold significant therapeutic potential. In this report, we demonstrate that inhibition of colony stimulating factor 1 receptor (CSF1R) signaling functionally reprograms macrophage responses to enhance antigen presentation, thereby stimulating anti-tumor T cell responses. However, this immune reprograming also leads to the upregulation of T cell checkpoint molecules, including PDL1 and CTLA4, which significantly limits the potential of the CSF1R blockade to induce anti-tumor responses. While both programmed cell death protein 1 and CTLA4 antagonists show limited efficacy as single agents to restrain PDAC growth in a mouse model, the combination of these agents with CSF1R blockade achieves disease regression even in well-established tumors. These data suggest that reprograming myeloid responses through CSF1R blockade can improve the efficacy of checkpoint-based immunotherapeutics in pancreatic cancer. Citation Format: Yu Zhu, Knolhoff Brett, Meyer Melissa, West Brian, Linehan David, David DeNardo. CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr B61.
Translation of Selected Passages from de l'Auscultation Médiate. (First Edition).
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Actinomycotic Pyaemia
Authors: J. D. Blainey, E. O. Morris
Journal: BMJ (1953)

INTRAVENOUS IRON IN RHEUMATOID ARTHRITISBRDIjrsH 913 less, normal and raised values occurring in all groups.The raised values always became normal after iron therapy, however, even in the absence of a material rise in haemo- globin level.Conchisions In 50 cases of rheumatoid arthritis, failure of their anaemia to respond to intravenous iron could not be predicted from the results of any of the investigations examined.Return of the haemoglobin to normality occurred regularly when one or more of the following were present: sedimentation rate below 30 mm. in one hour, microcytosis, gross hypochromasia, and raised total iron- binding capacity of the serum.The haemoglobin, however, returned to normal or improved greatly in many cases which showed none of the above criteria.It appears that intravenous iron is always worth trying in the anaemia of rheumatoid arthritis, except when severe constitutional disturbance or the imminence of surgery makes preferable the rapid rise in haemoglobin which follows blood transfusion.My thanks are due to Dr. G. D. Kersley for his helpful criticism and advice, and for allowing the investigation of patients in his care.I am indebted to Professor C