tbuckley/cabot-search huggingface dataset:
COUNCIL ON MEDICAL EDUCATION AND HOSPITALS
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension
Authors: José M. Fernández-Fernández, Marta Tomás, Esther Vázquez, Patricio Orio, Ramón Latorre, Mariano Sentí, Jaume Marrugat, Miguel A. Valverde
Journal: Journal of Clinical Investigation (2004)

Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca2+-dependent K+ (BK) channel. The BK channel in vascular smooth muscle is formed by an ion-conducting α subunit and a regulatory β1 subunit, which couples local increases in intracellular Ca2+ to augmented channel activity and vascular relaxation. Our large population-based genetic epidemiological study has identified a new single-nucleotide substitution (G352A) in the β1 gene (KCNMB1), corresponding to an E65K mutation in the protein. This mutation results in a gain of function of the channel and is associated with low prevalence of moderate and severe diastolic hypertension. BK-β1E65K channels showed increased Ca2+ sensitivity, compared with wild-type channels, without changes in channel kinetics. In conclusion, the BK-β1E65K channel might offer a more efficient negative-feedback effect on vascular smooth muscle contractility, consistent with a protective effect of the K allele against the severity of diastolic hypertension.
Coronary angiograms and myocardial scintigraphy
Authors: F. Vieras
Journal: JAMA (1979)

<h3>To the Editor.—</h3> We read the work by Galbraith et al (240:2053, 1978) concerning interobserver variability in the interpretation of coronary angiograms. These authors correlated the findings on premortem coronary angiograms of 20 patients with the postmortem pathological findings in fresh, unfixed heart specimens from the same patients. The authors used as a criterion for "substantial" lesions a reduction in lumen diameter of a given vessel of 50% or greater angiographically, or 75% reduction in cross-sectional area pathologically. Their basic results indicate that while minimal interobserver variability was present, there was considerable overall inaccuracy in the interpretation of coronary angiograms, with false-positive misinterpretations being the most common (about twice the false-negative rate). Within the context of their study, in which they set forth specific criteria for correlation of angiographic and pathological findings, the results are straightforward and of utmost validity. However, we wish to point out that in the clinical
Hypercalcemia and unilateral nephrocalcinosis
Authors: Hiroo H. Advani, Gurdip S. Sidhu
Journal: JAMA (1975)

PERSISTENT hypercalcemia is frequently associated with widespread metastatic calcification, most commonly in the kidneys, lungs, gastric mucosa, and blood vessels. This selective localization is believed to be due to unique physiological factors. Major pathological alterations in the function of these tissues may be expected to alter the distribution of calcium salt deposition. We are reporting a case in which nephrocalcinosis was largely confined to one kidney. It is our opinion that differences in the state of tubular glomerular function are responsible for this differential localization of calcium. <h3>Report of a Case</h3> A 51-year-old man was admitted to the New York Veterans Administration Hospital in August 1973 because of weight loss and pain in the lower back and left thigh, of several months' duration. Transurethral resections on two occasions and finally a partial cystectomy in September 1972 were performed for a transitional cell carcinoma of the urinary bladder diagnosed by cystoscopic
Hemolytic Anemia Caused by Penicillin
Authors: Leslie W. Nesmith
Journal: JAMA (1968)

Following the administration of ampicillin sodium, methicillin sodium, and penicillin G sodium to a patient with bronchopneumonia a direct Coombs' test was positive and hemolytic anemia developed. The patient's indirect Coombs' test was positive with group O erythrocytes previously incubated with penicillin G, ampicillin, methicillin, or cephalothin sodium. Adsorption of his serum with penicillin-treated erythrocytes reversed the positive reaction to the indirect Coombs' test with both penicillin-treated and cephalothin-treated erythrocytes. Eluates prepared from erythrocytes, which had been treated with either penicillin G or cephalothin and incubated with his serum, gave a positive indirect Coombs' test with penicillin-treated and with cephalothin-treated erythrocytes. The half-life of autologous erythrocytes treated with penicillin G and sodium chromate Cr 51 was less than 40 minutes. Although the patient had never received cephalothin before, the half-life of autologous cephalothin-treated erythrocytes was 135 minutes.
Infectious Syndromes of Leukemias and Lymphomas
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious diseases
Authors: R. G. Douglas
Journal: JAMA (1990)

The acquired immunodeficiency syndrome (AIDS) epidemic continues to dominate the subspecialty of infectious diseases. New basic science and clinically relevant data about AIDS continue to rapidly accumulate. Zidovudine (formerly named azidothymidine [AZT]) remains the only available agent for treatment of AIDS, but its effect is limited in duration. One long-suspected explanation is the development of resistance to zidovudine by the human immunodeficiency virus (HIV). Larder and coworkers<sup>1</sup>tested the sensitivity of HIV isolates to zidovudine in patients who had received zidovudine therapy. Most isolates obtained after 6 months or more of therapy were less sensitive than those obtained before or during the first few months of therapy. Although not proven, it is plausible that drug resistance may play a role in diminished clinical effectiveness of zidovudine after several months of therapy. If true, this finding could provide a strong argument for the use of drug combinations, either simultaneously or
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1956)

COMMITTEE ON MATERNAL WELFAREAfibrinogenemia after Rupture of the UterusA twenty-seven-year-old woman, with 2 previous normal deliveries and a completely uneventful prenatal course, entered the hospital in early labor when thirty-nine weeks pregnant. The membranes were intact. Seven hours later a physician found her in active labor, with the cervix dilated 4 cm. and the membranes bulging. Demerol and Seconal were given. No oxytocics were administered. About five minutes later the membranes ruptured spontaneously, and tumultuous labor followed. On re-examination the cervix was found to be fully dilated.Spinal anesthesia (Pontocaine, 5 mg.) was given for delivery at 10:24 . . .
Adaptive Autocrine Secretion of the Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) Mediates Imatinib- and Nilotinib-Resistance in BCR/ABL-Positive Progenitors Via JAK-2/STAT-5 Pathway Activation.
Authors: Andreas Burchert, Ying Wang, Cornelia Brendel, Philipp Erben, Paul W. Manley, Andreas Hochhaus, Dali Cai, Andreas Neubauer
Journal: Blood (2006)
Donor cell leukemia: Report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature
Authors: Linda D. Cooley, David A. Sears, Mark M. Udden, Wilbur R. Harrison, Kelty R. Baker
Journal: American Journal of Hematology (2000)

We report the case of a man with chronic myelocytic leukemia (CML) and a 46,XY,t(5;9;22) karyotype who developed acute myelocytic leukemia (AML) with a 45,X,t(8;21) karyotype 11 years after bone marrow transplantation (BMT) from his HLA-matched sister.Fluorescent in situ hybridization (FISH) studies and molecular analysis using short tandem repeat (STR) sequences proved the new leukemia to be of donor cell origin.Donor cell leukemia (DCL) after BMT is rare.Our review of the literature found 15 cases following BMT for leukemia and 2 cases after BMT for benign hematological disorders.In fewer than half the reported cases were molecular studies available to confirm the cytogenetic evidence for DCL, and the longest previously reported interval between BMT and DCL was 6 years.Am.
ATTAIN: Phase 3 study of etirinotecan pegol (EP) vs. treatment of physician's choice (TPC) in patients (pts) with metastatic breast cancer (MBC) who have stable brain metastases (BM) previously treated with an anthracycline, a taxane, and capecitabine (ATC).
Authors: Debu Tripathy, Sara M. Tolaney, Andrew David Seidman, Carey K. Anders, Nuhad K. Ibrahim, Hope S. Rugo, Chris Twelves, Véronique Diéras, Volkmar Mueller, Alison Hannah, Mary Ann Tagliaferri, Javier Cortés
Journal: Journal of Clinical Oncology (2018)

TPS1111 Background: EP is a next-generation topoisomerase I inhibitor-polymer conjugate that provides continuous exposure to SN-38, the active metabolite. A BM mouse model showed high penetration and retention of SN-38 in CNS lesions, resulting in decreased size of CNS lesions and improved survival at concentrations achieved at the recommended dose in pts (Adkins BMC Cancer 2015). Although a phase 3 trial (BEACON) of EP vs TPC in 852 pts with advanced BC did not meet its primary endpoint of overall survival (OS) (HR 0.087; P = 0.08), a subset of 67 pts with stable BM showed improved OS (HR 0.51 [95% CI 0.30-0.86]; P < 0.01) (Perez Lancet Oncol 2015). The current phase 3 trial (ATTAIN) was designed for this subpopulation of pts having high unmet medical need. Methods: Pts with MBC with locally treated stable BM will be randomized 1:1 to EP or TPC in an open-label phase 3 study. Eligibility includes: ECOG PS 0 or 1; adequate organ function; prior ATC therapy (neo/adjuvant or locally advanced/MBC setting); ≥1 prior cytotoxic regimen for pts with triple negative MBC; ≥2 prior cytotoxic regimens for pts with HR+ or HER2+ BC (pts with HR+/HER2+ BC must have received prior hormone therapy/HER2 targeted therapy); prior definitive local therapy of BM (whole brain radiation [RT], stereotactic RT or surgical resection as single-agent or combination); and stable signs/symptoms of BM with steroids (ie, unchanged or decreasing ≥7 days prior to randomization). Primary endpoint is OS. Key secondary endpoints are ORR and PFS by RECIST v1.1 and RANO-BM, clinical benefit rate (ORR+SD ≥ 6 months) and QoL. Pts randomized to TPC will receive 1 of 7 cytotoxic IV agents. Pts are stratified by region, PS and receptor status. 350 pts will be randomized to obtain the number of events required at 90% power to detect a statistically significant improvement in OS (hypothesizing HR = 0.67); 1 interim analysis is planned at 50% of deaths (130 events). PK sampling and UGT1A1 testing will be performed in the EP arm; plasma ctDNA will be assessed for potential predictive markers of efficacy. Enrollment began early 2017. Clinical trial information: NCT02915744.
Human Olfaction without Apparent Olfactory Bulbs
Authors: Tali Weiss, Timna Soroka, Lior Gorodisky, Sagit Shushan, Kobi Snitz, Reut Weissgross, Edna Furman-Haran, Thijs Dhollander, Noam Sobel
Journal: Neuron (2019)

The olfactory bulbs (OBs) are the first site of odor representation in the mammalian brain, and their unique ultrastructure is considered a necessary substrate for spatiotemporal coding of smell. Given this, we were struck by the serendipitous observation at MRI of two otherwise healthy young left-handed women, yet with no apparent OBs. Standardized tests revealed normal odor awareness, detection, discrimination, identification, and representation. Functional MRI of these women's brains revealed that odorant-induced activity in piriform cortex, the primary OB target, was similar in its extent to that of intact controls. Finally, review of a public brain-MRI database with 1,113 participants (606 women) also tested for olfactory performance, uncovered olfaction without anatomically defined OBs in ∼0.6% of women and ∼4.25% of left-handed women. Thus, humans can perform the basic facets of olfaction without canonical OBs, implying extreme plasticity in the functional neuroanatomy of this sensory system.
Response
Authors: H. ADLERCREUTZ, S. L. GORBACH, B. R. GOLDIN, M. N. WOODS, J. T. DWYER, E. HÄMÄLÄINEN
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Response Get access H. ADLERCREUTZ, H. ADLERCREUTZ Search for other works by this author on: Oxford Academic PubMed Google Scholar S. L. GORBACH, S. L. GORBACH Search for other works by this author on: Oxford Academic PubMed Google Scholar B. R. GOLDIN, B. R. GOLDIN Search for other works by this author on: Oxford Academic PubMed Google Scholar M. N. WOODS, M. N. WOODS Search for other works by this author on: Oxford Academic PubMed Google Scholar J. T. DWYER, J. T. DWYER Search for other works by this author on: Oxford Academic PubMed Google Scholar E. HÄMÄLÄINEN E. HÄMÄLÄINEN Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 21, 2 November 1994, Pages 1644–1645, https://doi.org/10.1093/jnci/86.21.1644 Published: 02 November 1994
British Stomach Cancer Group
Authors: P Mcculloch, A Ochiai, J O'dowd, J Nash, M Sasako, S Hirohashi, N Keeling, J Livingstone, M Filipet, C Wastell
Journal: Gut (1994)

The incidence, stage at diagnosis, and cur- ability of gastric cancer differ markedly between Japan and Western countries.The genetic and environmental influences on gastric carcinogenesis are very different in the two populations, and some Western authors have postulated a less aggressive type of cancer in Japan.We sought evidence of differences in tumour biology by comparing the incidence of p53 and c-erbB2 gene abnormalities in British and Japanese gastric cancer.Eighty five British cases were carefully matched for T stage and tumour grade with 89 contemporary Japanese cases.Archival paraffin sections were microwaved and immunohistochemically stained by 2 stage alkaline phosphatase/anti-alkaline phosphatase technique.The results are shown in the Table.p53 -+ c-erbB2 -British Japanese 46 46 39 43 26 28 59 61Diffuse cancers from each centre were less commonly positive for either antigen than intestinal cancers.British and Japanese tumours matched for stage and grade show similar frequencies of p53 and c-erbB2 abnormalities.These results provide no support for the idea of different forms of gastric cancer in East and West.
Should physicians prescribe prayer for health? Spiritual aspects of well-being considered
Authors: C. Marwick
Journal: JAMA (1995)

SHOULD PHYSICIANS write "prayer" or "more frequent participation in religious observances" when prescribing for their patients? Some physicians, chaplains, pastoral workers, and sociologists would answer affirmatively. "There is at work an integration of medicine with religion, of spirituality with medical practice, the twin guardians of healing through the ages," said Dale Matthews, MD, associate professor of medicine, Georgetown University School of Medicine, Washington, DC, at a meeting presented as "the first conference on Spiritual Dimensions in Clinical Research." The meeting, meant to "explore the current body of knowledge and emerging trends in the area of spirituality and health," was held in Leesburg, Va, by the National Institute for Healthcare Research, a private organization devoted to examining the role of religious commitment in improving patient care and well-being. The agenda concentrated on three general areas: alcohol and other drug abuse, mental health, and physical health. Conferees reviewed the current status of
Street drugs yield primate Parkinson's model
Authors: E. Blume
Journal: JAMA (1983)

The tragic mistake of several young drug abusers has led scientists at the National Institute of Mental Health (NIMH) to develop a unique animal model of Parkinson's disease. The animals are rhesus monkeys, and their parkinsonism is produced with 1-methyl4-phenyl-1,2,5,6-tetrahydropyridine (MPTP), a byproduct of the synthesis of a meperidine (Demerol) analogue, MPPP. The story began in November 1976, when a 23-year-old chemistry graduate student became severely rigid, mute, weak, and tremorous. He had injected himself during the course of several days with doses of a "sloppy" homemade batch of MPPP. He was admitted to the psychiatric ward of a general hospital with an initial diagnosis of catatonic schizophrenia but later was successfully treated with anti-parkinson medications and referred to NIMH for further evaluation. While receiving treatment for his parkinsonian symptoms, the student persisted in abusing drugs and finally died of an overdose in September 1978. Autopsy revealed severe loss of
Datum Insipientum
Authors: G. G. Liddle
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Things might have been better in Roman days, when the title of this<i>epistola</i>would have been close to nonsense, because<i>datum</i>was nothing but a past participle. Much later this great and good word found its way into the English language, and the erudition which makes its plural<i>data</i>is one of those perennial editorial delights. Some authors pluralize, and some not. This is meat and drink to editors, as they leap upon "data is." Whenever "data" is used as a plural, some editor should receive a medal for service "over and above the call of duty." The loftier brand, however, scorns this lowly sport, and prefers to leave the error in place (<b>195</b>:833, 1966). There is another puzzling feature of this matter. Never, in a scientific publication, is a small datum reported. They are always "data." I posed this problem to my 3-year-old niece
Contents page
Authors: Anna Nobre, Jill O'reilly, Richard Davidson, Alexander Shackman, Jeffrey Maxwell, Christopher Kello, Thomas Polger, Vittorio Gallese, Christian Keysers, Giacomo Rizzolatti, Susan Gelman, M Rushworth, M Walton, S Kennerley, D Bannerman, Daniel Bullock Trendsin, Julian Ogilvie, Arthur Wadsworth, Manager Moulton
Journal: Trends in Cognitive Sciences (2004)
Chemoembolization: transcatheter management of neoplasms
Authors: V. P. Chuang
Journal: JAMA (1981)

"Chemoembolization," the combination of intra-arterial infusion of a chemotherapeutic agent and arterial embolization of the vascular supply to a neoplasm as proposed by Kato et al elsewhere in this issue (p 1123), presents an interesting concept with considerable potential. In addition to the direct effect of ischemia on the neoplasm by temporary occlusion, the emboli decrease the transit time through the tumor vascular bed, theoretically increasing the contact time of the chemotherapeutic agent with the neoplastic cell, increasing local drug concentration, and probably increasing tissue permeability because of the anoxia. The cytotoxic effect is not only on the neoplasm, but on the vessel embolized and infused, producing vasculitis and occlusion. The systemic toxic effect may be reduced by metabolism of the drug on its first passage through the infused organ, thereby confining the higher concentration of the chemotherapeutic agent to the target organ. There is considerable clinical support for each
Segmental quantitative analysis of color kinesis images using a bullseye representation in normal subjects Luiz O. Murta-Jr, Evandro E. S. Ruiz, Antonio Pazin-Filho, Andr� Schmidt, Oswaldo C. Almeida-Filho, Marcus V. Sim�es, Jos� A. Marin-Neto, Benedito C. Maciel. Medical School of Ribeir�o Preto, University of S�o Paulo, Ribeir�o Preto, Brazil
Journal: Journal of the American College of Cardiology (2001)
Clinical Endocrinology: Theory and Practice
Authors: Frederick G. Berlinger
Journal: JAMA (1987)

This new English translation of the third German edition of<i>Clinical Endocrinology: Theory and Practice</i>by Alexis Labhart is a well-written, lengthy textbook that in nearly 1100 pages attempts to cover the entire field of clinical endocrinology. As with the first English edition, a great strength of this textbook lies in the strong emphasis on basic science at the beginning of each chapter. Most chapters begin with a brief historical outline concerning the endocrine organ or system involved, followed by concise outlines of the embryology, histology, gross anatomy, biochemistry, and physiology of the various endocrine organs and their secretions. These introductory sections are then followed by classic descriptions of the pathophysiological states that may be encountered. The emphasis on basic science, as well as on diagnosis and differential diagnosis, makes this a most useful reference source for the practicing clinician, advanced medical student, and resident physician. <i>Clinical Endocrinology</i>is written
Drug Substitution
Authors: Kenneth L. Beers
Journal: JAMA (1979)

<h3>To the Editor.—</h3> This is a report of a clinical failure with substituted tolbutamide. My letter is prompted by the potentially serious situation that was created when one of my diabetic patients permitted substitution without my knowledge of a refill prescription for a specific brand of tolbutamide. <h3>Report of a Case.—</h3> The patient was a 71-year-old woman whose diabetes had been stabilized for seven years with diet and a daily dosage of tolbutamide (Orinase), 500 mg four times a day. The patient's fasting and postprandial blood glucose levels were generally maintained within a range of 100 to 140 mg/dL, and no noteworthy clinical complications associated with blood glucose control had occurred during her relatively long history of diabetes mellitus. During a routine visit to my office, the patient's blood glucose level was found to be 400 mg/dL, and she mentioned that she had not been feeling well. Careful questioning of