tbuckley/cabot-search huggingface dataset:
The AMA specialty journals: everyone, including grunts, squeals unfair
Journal: JAMA (1990)

<h3>To the Editor. —</h3> I read with interest your recent editorial on "Reaching the Readers: Experience With the AMA Specialty Journals."<sup>1</sup>Your strategy was certainly sound and your results were impressive. Before your policy and strategy were implemented in 1988, I looked forward to receiving the<i>Archives of Internal Medicine</i>and read the journal with great interest. Now I am excluded from receiving any of your specialty journals, despite being in the second largest medical specialty of family medicine. This greatly distresses me. I think a specialty journal for family medicine needs to be developed and distributed as the other specialty journals are, or family physicians should be given their choice of a medical specialty journal. As the AMA attempts to represent all physicians, it is appalling that it neglects this large segment of practicing physicians.
Die Zuckerkrankheit und ihre Behandlung.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Hepatology (1996)

We have shown that antisense oligonucleotides can be targeted to hepatitis B virus (HBV)-infected cells, resulting in specific inhibition of viral protein synthesis and replication in vitro. The targeting system was based on the internalization of DNA complexes by highly selective receptors for galactose-terminal glycoproteins, asialoglycoproteins, on the surface of hepatocytes. Our objective in this study was to determine whether antisense DNA could be targeted to hepatocytes to prevent subsequent infection by HBV. A 21-mer phosphorothioate-linked oligo DNA complementary to the HBV polyadenylation signal and 5'-upstream sequences was complexed to a targetable DNA carrier consisting of asialoglycoprotein coupled to polylysine. Pretreatment of Huh7, asialoglycoprotein receptor (+) cells, with antisense complexes before lipofection with an HBV-plasmid at a level of 6.5 x 106 copies of plasmid per cell inhibited the amount of newly synthesized, core-associated viral DNA in Huh7 cells to undetectable levels, less than 0.1 pg, as assessed by quantitative polymerase chain reaction (PCR). Hepatitis B viral RNA transcripts were decreased by 60% compared with controls as detected by RNase protection assays, and HBV surface antigen (HBsAg) accumulation was inhibited by 97%. The inhibition lasted for 6 days and was dose dependent. Controls consisting of antisense alone and a random oligo complex showed no significant effect on any of the parameters under identical conditions. We conclude that preexposure of cells to targeted complexed antisense DNA can substantially block viral gene expression and viral replication after transfection of HBV DNA. (Hepatology 1996 Jun;23(6):1297-303)
TRICHOPHYTOSIS.
Authors: J. B. KESSLER
Journal: JAMA (1902)

The too frequent prevalence of ringworm and the importance of its prophylaxis have induced me to offer the following observations and suggestions, hoping that they will emphasize one or more points as to the etiology of this inconvenient disorder. The disease is always produced by the trichophyton. White of Boston has called especial attention to the frequency of its origin in the barber shop, a fact which common experience verifies. But how does it get there? All authors say, from the domestic animals, viz., dog, cat, horse, white mice, to man. In the stock-raising districts I think the most frequent source is from cattle, and especially from yearling calves. I say yearlings, because I do not think older cattle as good soil for the production of the parasite. The farmers handle their stock, become infected, go to the barber shop and get shaved, and the next person to take the
CONSTRUCTION OF STATUTORY PROVISIONS FOR THE CARE OF INDIGENT SICK.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral Surgery.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastric Carcinoma
Authors: Charles S. Fuchs, Robert J. Mayer
Journal: New England Journal of Medicine (1995)

Despite a marked decline in the incidence of gastric carcinoma in many industrialized nations, cancer of the stomach remains the second most common cause of cancer-related deaths in the world.1 In 1995, 22,800 Americans will be given a diagnosis of gastric carcinoma, and 14,700 will die of the disease.2 This review discusses recent developments in our understanding of the epidemiology and pathogenesis of gastric carcinoma, methods of diagnosis and staging, and approaches to treatment and palliation.Epidemiology and BiologyIncidenceIn 1930, gastric carcinoma was the leading cause of cancer-related deaths among American men and the third most common cause . . .
Bishop Barry on Antivivisection
Authors: A. Barry
Journal: BMJ (1894)

<h3>Summary</h3> <h3>Goals:</h3> The ability of the yeast <i>Brettanomyces</i> to produce negative aroma attributes from grape phenolic precursors is well known. However, this yeast synthesizes a broad array of aroma-active compounds in wines, some of which are valued or deemed positive in certain wine styles or matrices. To better understand the spectrum of positive and negative aroma traits associated with the presence of <i>Brettanomyces</i> in wine, we created an aroma wheel to categorize and describe the variety of aroma impacts of this yeast on the basis of analyses of aroma-active compound production from spiked precursor compounds in a model controlled environment. <h3>Key Findings:</h3> The <i>Brettanomyces</i> aroma wheel categorizes many of the aroma descriptors associated with wine spoilage by <i>Brettanomyces</i>. Terms on the wheel may categorize aroma-active compounds generally associated with microbial infection of both <i>Brettanomyces</i> and lactic acid bacteria (LAB). There is no evidence for a <i>Brettanomyces</i> strain that produces only positive characters in wine. <h3>Impact and Significance:</h3> A comprehensive <i>Brettanomyces</i> aroma wheel was generated with different strains under controlled product–precursor conditions and tested for broader utility in commercial winemaking. Thirty commercial wines described by wine critics using two or more of the identical or similar terms to those found on the <i>Brettanomyces</i> aroma wheel were obtained from a retail outlet. All wines purchased had evidence of presence of <i>Brettanomyces</i>, LAB, or both. The inner circle, or general categories of the wheel, were used more commonly by critics in describing wines and the specific terms (outer wheel) less generally used as commercial wine descriptors. The terms presented on the aroma wheel can therefore be used to determine if a wine is likely to have sensory characteristics contributed by <i>Brettanomyces</i> or LAB. This appeared to be particularly true for the general categories “savory,” “woody,” “spicy,” “floral,” “earthy,” “chemical,” and “animal.” Thus, the wheel can be used to identify wines with a strong, but not necessarily negative, microbial signature.
European Pancreatic Club
Authors: J Christophe, A Abdeljlil
Journal: Gut (1966)

The ingestion of gluten, as sole dietary protein, results in severe lysine deficiency and subacute threonine de- ficiency in young rats.These animals stop growing forth- with.After three weeks changes are found in the exo- crine pancreas.The mitotic index is low.The apex of acinar cells shrinks, and the cell contains on an average 38% less protein and 19% less RNA-P.The decrease in protein content mostly affects hydrolases, amylase, chymotrypsinogen, trypsinogens, lipase, and pro- carboxypeptidase B, and more especially the first three of these proteins.A relative increase in the secretion of pancreatic enzymes is noted in the small intestine.When deficient rats are allowed to recover on a complete diet, spectacular recovery is observed after three days.The mitotic index of acinar cells increases seventeen- fold and the apex of the cell reverts to normal size, being refilled with hydrolases.By following the kinetics of adaptative changes in the pancreas more closely, in lysine deficiency as well as during recovery from lysine deficiency, it becomes obvious that major modifications in enzyme concentration develop within 24 hours.The velo- city and magnitude of the variations in amylase and chymotrypsinogen are especially striking.
Primary immunodeficiency disease presenting in midlife
Authors: S. J. Kornfeld
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The vast majority of genetically defined primary immunodeficiency diseases are typically considered within the context of the pediatric population.1 Genetic confirmation of primary immunodeficiency diseases in patients with atypical clinical features and often uninformative family histories has emphasized the wide phenotypic variation associated with these disorders.<sup>2</sup>The Bruton tyrosine kinase (<i>Btk</i>) gene, which is mutated in X-linked agammaglobulinemia (XLA), represents the most extensively studied example of genetic mutation in a primary immunodeficiency disease1: at least 228 unique mutation events are known to be associated with XLA.<sup>3</sup>Less than 25% of known mutations have been identified in 2 or more unrelated individuals,<sup>3</sup>suggesting the possibility of additional mutant genotypes (and phenotypes). The phenotypic presentation of XLA is varied in terms of numbers of B cells, immunoglobulin levels, and clinical presentation. We have recently identified a novel mutation, which introduces a premature termination codon in<i>Btk</i>
REVIEWS
Journal: British Journal of Dermatology (1919)

British Journal of DermatologyVolume 31, Issue 1 p. 65-65 REVIEWS First published: January 1919 https://doi.org/10.1111/j.1365-2133.1919.tb09692.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume31, Issue1January 1919Pages 65-65 RelatedInformation
OxyContin
Authors: Art Van Zee
Journal: Annals of Internal Medicine (2004)

Ad Libitum6 April 2004OxyContinArt Van Zee, MDArt Van Zee, MDFrom St. Charles, VA 24282.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-7-200404060-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It might have been easierif OxyContin swallowed the mountains, and tookthe promises of tens of thousands of young lives,Slowly, like ever-encroaching kudzu.Instead,it engulfed us,gently as napalmwould a school-yardMama saidAs hard as it was to bury Papaafter the top fellin the mine up Caney Creek,it was harder yetto find Sis that morningcold and blue,with a needle stuck up her arm.Top of her class,with nothing but promise aheaduntil hi-jacked bythe torment of needle and spoon.Art Van Zee, MDSt. Charles, VA 24282 Author, Article, and Disclosure InformationAffiliations: From St. Charles, VA 24282.Current Author Address: Art Van Zee, MD, Stone Mountain Health Services, PO Drawer S, St. Charles, VA 24282. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 April 2004Volume 140, Issue 7Page: 527KeywordsMedical servicesOxycodone ePublished: 6 April 2004 Issue Published: 6 April 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Practice Guidelines
Authors: Peter G. Goldschmidt
Journal: JAMA (1990)

<h3>To the Editor.—</h3> In his article on practice guidelines, Dr Brook<sup>1</sup>explains well the need for and the various forces driving toward practice guidelines and their value if developed and used appropriately. However, he fails to explore adequately their competing purposes and objectives and how these considerations might influence their content and use. Of particular concern are his emphasis on "one set fits all" and his desire for a single purveyor of the truth. Practice guidelines encompass many uses, for example, prospectively assisting a physician to select the most appropriate diagnostic and therapeutic interventions and retrospectively assessing a physician's quality of care. Until complete guidelines can be developed, depending on their purpose, they will differ. Practice guidelines are shaped by the extent to which costs are equated with benefits. Usually, practice guidelines are conceived in the context of a given health problem and any trade-offs among costs and
Genetic Ancestry and Skeletal Toxicities Among Childhood Acute Lymphoblastic Leukemia Patients in the DFCI 05-001 Cohort
Authors: Qianqian Zhu, Song Yao, Peter D Cole, Justine M. Kahn, Marian H. Harris, Emily Schiller, Uma Athale, Luis A. Clavell, Caroline Laverdiere, Jean-Marie Leclerc, Bruno Michon, Marshall A. Schorin, Jennifer J.G. Welch, Stephen E. Sallan, Lewis B. Silverman, Kara M. Kelly
Journal: Blood (2019)
THU0033 Age-associated b cells in early drug-naÏve rheumatoid arthritis patients
Authors: A.E. Anderson, G. Vidal-Pedrola, D. Scheel-Toellner, A. Pratt, A. Mellor, J. Isaacs
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterised by joint inflammation and bone destruction. The presence of autoantibodies, years before the clinical onset of disease, and the efficacy of Rituximab, a B-cell depleting therapy, highlight a pathogenic role for B cells. Different groups have recently identified a novel subset of B cells named age-associated B cells (ABCs). Studies in mice autoimmune models and patients suffering from autoimmune diseases described these cells as CD19<sup>high</sup> CD21<sup>-</sup> CD11c<sup>+</sup>. Moreover, a subset of synovial fluid B cells with low levels of CD21, expresses FcRL4 and produces the cytokine RANKL, which stimulates the differentiation and activation of osteoclasts. The ABCs found in peripheral blood could therefore be the precursors of this FcRL4 positive subset found in synovia. <h3>Objectives</h3> We aimed to investigate the proportion and phenotype of peripheral blood ABCs in patients suffering from early drug naïve RA. <h3>Methods</h3> Newly presenting patients, naïve to immunomodulatory treatment, were recruited from the Newcastle Early Arthritis Clinic, and followed until diagnoses were confirmed. B-cell subsets in peripheral blood were detected and phenotyped using flow cytometry. <h3>Results</h3> Our work showed increased proportions of ABCs in seropositive RA compared to other inflammatory arthritis controls, highlighting a potential link between autoantibody production and ABCs. Moreover, patients with high disease activity had higher proportions of ABCs in peripheral blood. Interestingly, the FcRL4<sup>+</sup>, the proliferating Ki67<sup>+</sup> and the T-bet expressing B cells were enriched in the ABC population compared to the other B cell subsets. Furthermore, ABCs expressed high levels of MHC class II and co-stimulatory molecules, as well as the activation marker, CD69. <h3>Conclusions</h3> These data supports a possible pathogenic role of ABCs in RA, potentially via autoantibody and T cell stimulatory ability, but further characterisation of this subset and functional studies are needed. <h3>Disclosure of Interest</h3> None declared
Olfactory dysfunction
Authors: Katie Love, Shadaba Ahmed
Journal: BMJ (2010)

Losing the sense of smell is an under-recognised problem Loss of sight or hearing is well recognised by the public and professionals. However, the potentially devastating loss of the sense of smell is not so widely recognised and is overlooked as a public health problem.12 Olfaction refers to the sense of smell and arises from the complex interaction between odorants and the sensory receptors in the cribriform plate,3 which is in the roof of the nasal cavity and makes up what is known as the “olfactory epithelium.”34 Bipolar sensory receptors transfer incoming signals through a series of neurones to reach the temporal lobe of the brain known as the primary olfactory area, where the conscious area of smell begins.3 The primary olfactory area also has connections with the frontal lobe, which is involved in odour identification and discrimination.3 When this intricate system goes awry people may complain of problems with their sense of smell—olfactory dysfunction—of which there are several types (box 1).1 The topic is vast, and this article focuses on people who are principally affected by a diminished or absent sense of smell, referred to as hyposmia or anosmia. There are several different causes (box 2). Olfactory deficits have also been linked to neurological disorders such as epilepsy, Parkinson’s disease, and Alzheimer’s disease.5 Health professionals should be aware of these as a result of the potential severity of these associated conditions. #### Box 1: Types of dysfunction1
Yamagiwa-Yoshida Memorial International Cancer Study Grants
Journal: JNCI Journal of the National Cancer Institute (1985)

Yamagiwa-Yoshida Memorial International Cancer Study Grants Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 3, September 1985, Page 594, https://doi.org/10.1093/jnci/75.3.594 Published: 01 September 1985
Mass Treatment of Humans Exposed to Rabies-New Hampshire, 1994
Journal: JAMA (1995)

On October 22, 1994, the laboratory of the New Hampshire Division of Public Health Services (NHDPHS) diagnosed rabies in a kitten that had been purchased from a pet store in Concord, New Hampshire. On October 19, the animal had developed seizures, then died of unknown causes during the night of October 20-21. Approximately 665 persons received rabies postexposure prophylaxis because of exposure to this kitten and other cats from the same pet store. This report summarizes the epidemiologic investigation of the source of the infection and follow-up care of humans and animals potentially exposed to rabies.