THE RELATION OF CHOLESTEROL TO THE DEVELOPMENT OF ATHEROSCLEROSIS
Authors: P. W. C.
Journal: Annals of Internal Medicine (1950)

Editorial1 July 1950THE RELATION OF CHOLESTEROL TO THE DEVELOPMENT OF ATHEROSCLEROSISP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-1-250 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterest in the relationship of cholesterol to the development of arteriosclerosis dates from the demonstration by Aschoff more than 40 years ago that large amounts of cholesterol and other lipids are present in the atheromatous lesions of the aorta and its larger branches. This interest was greatly intensified by Anitschkow's report (1911) of the experimental production of similar atheromatous lesions in rabbits by feeding cholesterol for long periods. Anitschkow's observations have been abundantly confirmed, and a huge literature has accumulated on this subject.1, 2, 3Although arterial lesions can be produced experimentally by other means, no other procedure has caused...1 Leary T: The genesis of atherosclerosis, Arch. Path. 32: 507-555, 1941. Google Scholar2 Hueper WC: Arteriosclerosis (a general review), Arch. Path. 39: 51 et sq., 1945. Google Scholar3 KatzDauber LNDV: The pathogenesis of arteriosclerosis, J. Mount Sinai Hosp. 12: 382, 1945. Google Scholar4 Winternitz MC: Studies in Pathology of vascular disease, Am. Heart J. 14: 399-404, 1937 CrossrefGoogle Scholar5 HorlickKatz LLN: The relationship of atheromatosis development in the chicken to the amount of cholesterol in the diet, Am. Heart J. 38: 336-349, 1949. CrossrefMedlineGoogle Scholar6 SteinerKendall AFE: Atherosclerosis and arteriosclerosis in dogs following ingestion of cholesterol and thiouracil, Arch. Path. 42: 433-444, 1946. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE VALUE OF DETERMINATIONS OF CHOLESTEROL AND OF LIPOPROTEINS OF LOW DENSITY IN THE BLOOD AS PREDICTORS OF OVERT ATHEROSCLEROSISRECENT HISTORY OF CORONARY DISEASE 1 July 1950Volume 33, Issue 1Page: 250-258KeywordsAortaAtherosclerosisCholesterolLesionsLipidsRabbits ePublished: 1 December 2008 Issue Published: 1 July 1950 PDF downloadLoading ...