tbuckley/cabot-search huggingface dataset:
Reactor Accidents
Authors: David V. Becker
Journal: JAMA (1987)

In a reactor accident with release of radioactivity, the major potential public health risks are likely to result from radioiodines, particularly iodine 131, which can be readily volatilized and dispersed. They are rapidly absorbed and concentrated by the thyroid, which could result in substantial thyroidal radiation. Although some forms of radiation can cause thyroid cancer in humans,<sup>131</sup>I has not been shown to do so, and 40 years of safe experience with this radionuclide in routine clinical thyroid testing and treatment has been reassuring. Nevertheless, since<sup>131</sup>I has been shown to cause thyroid neoplasms in animals, efforts to minimize unwarranted exposure seem advisable. Potassium iodide, administered at an appropriate time, will effectively block thyroid uptake, but it has potential toxicity and may be difficult to distribute effectively and safely on a large scale in an emergency. Evaluation of the risks and benefits of potassium iodide use is essential to establishing sound public health policy but awaits additional scientific information. (<i>JAMA</i>1987;258:649-654)
Die Histopathologie der Uterusmucosa: Ein Leitfaden für Gynäkologen und Pathologen bei der histologischen Diagnostik.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Percutaneous lumbar diskectomy
Authors: P. Kambin
Journal: JAMA (1989)

<h3>To the Editor.—</h3> I read with interest the article on percutaneous lumbar diskectomy in the January 6 issue of<i>JAMA</i>.<sup>1</sup>Although I do not believe it was the intention of the author to advocate or endorse any particular instrumentation, the discussion seemed to be more promotional than scientific, for the following reasons. Obviously, most of the panel members are neurosurgeons and users of the nucleotome (20 neurosurgeons and 6 orthopedic surgeons). The article quotes one surgeon who has performed 200 operations with no complications. The article even reports the opinion of the manufacturer of the nucleotome. To the best of my knowledge, the users of what are considered to be manual instruments were not included, consulted, or interviewed for this study. The term manual instrument is misleading. When the 4.5-mL cannula is positioned, one can introduce all kinds of automated instruments for evacuation of disk material. These
THE DISPENSARY PROBLEM.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMMUNITY.CHAPTER XXXI.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Children's Diet in Home and School.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CHOLECYSTOGASTROSTOMY AND THE COURVOISIER GALLBLADDER
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combination chemotherapy and radiation therapy for small cell carcinoma
Authors: P. Y. Holoye
Journal: JAMA (1977)

A three-drug combination of the chemotherapeutic agents cyclophosphamide, vincristine sulfate, and doxorubicin hydrochloride was given to 45 patients with small cell bronchogenic carcinoma. In addition, patients with limited disease received radiation therapy to the primary tumor. The complete response rate was 44%, with a median survival of 50 weeks. The partial response rate was 29%, with a median survival of 35 weeks. Patients who did not respond to therapy showed a median survival of only 12 weeks. Twenty percent of the patients had their first recurrence in the brain, and the median survival from the time of disease recurrence was ten weeks. Bone marrow metastasis was encountered in 24% of the patient population, but this did not adversely affect survival. (<i>JAMA</i>237:1221-1224, 1977)
Reactions to local anesthetics
Authors: J. Adriani
Journal: JAMA (1966)

Local anesthetics are used widely by practically all physicians, most of whom are not fully aware of the lethal potential of local anesthetics and the swiftness with which they may precipitate a catastrophe. The perineural concentration of a local anesthetic necessary to interrupt conduction in a nerve fiber is many times greater than that which a patient will tolerate if that drug is circulating in the plasma. The majority of clinically useful local anesthetics are tertiary amines and are, therefore, basic substances.<sup>1</sup>They form aqueous solutions that are alkaline in reaction. The bases are poorly soluble in water, but they readily form water soluble salts with acids. The bases are less stable than the salts. The salts, by virtue of their greater solubility and stability, are used for injection and topical application. Although aqueous solutions of the salts are acid in reaction, when injected they are converted to the
Effect of Platinum and Palladium Salts on Thymidine Incorporation into DNA of Rat Tissues
Authors: Richard F. Fisher, David J. Holbrook, Hansford B. Leake, Paul E. Brubaker
Journal: Environmental Health Perspectives (1975)

The intraperitoneal administration of PtCl4 or Pd(NO3)2 at levels of 28 or 56 mumole/kg body weight decreased the thymidine incorporation into DNA of spleen, liver, kidney, and testis. Spleen was most sensitive to both the platinum and the palladium salt. In liver, DNA syntheses in parenchymal cells and stromal cells were about equally sensitive to PtCl4. In control rats, only 20-30% of the 3H in the acid-soluble fraction of liver or spleen was in the form of thymidine and its phosphate esters 2 hr after the intraperitoneal injection of 3H-thymidine; prior injection of PtCl4 (56 mumol/kg body weight) did not change the pattern.
Re: Russell E.N. Becker, Alexa R. Meyer, Aaron Brant, et al. Clinical Restaging and Tumor Sequencing are Inaccurate Indicators of Response to Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.07.016
Authors: Gopa Iyer, Bernard H. Bochner, Eliezer M. Van Allen, David B. Solit, Jonathan E. Rosenberg
Journal: European Urology (2020)
Pharmacogenetics
Authors: Elliot S. Vesell
Journal: New England Journal of Medicine (1972)

History, Definitions and Clinical ApplicationsIN 1957 Motulsky1 laid the conceptual foundations of pharmacogenetics; in 1959 Vogel2 coined the word; and in 1962 Kalow3 wrote the first text on the subject. Opinion varies over what limits should be imposed on the term and to what extent pharmacogenetic principles can be usefully applied in clinical medicine. Pharmacogenetics deals with clinically important hereditary variations in response to drugs.4 In patients with pharmacogenetic lesions, toxicity or other unusual responses to a drug are genetically determined expressions of a qualitative or quantitative alteration in a drug-metabolizing enzyme or receptor site on which the drug . . .
Authors' reply
Authors: R. C KUKREJA, M. L HESS
Journal: Cardiovascular Research (1993)

Journal Article Authors' reply Get access RAKESH C KUKREJA, RAKESH C KUKREJA Division of Cardiopulmonary Laboratories, Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar MICHAEL L HESS MICHAEL L HESS Division of Cardiopulmonary Laboratories, Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 1, January 1993, Page 142, https://doi.org/10.1093/cvr/27.1.142 Published: 01 January 1993
MORAL INSANITY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heterophilic antibodies interfering with radioimmunoassay. A false-positive pregnancy test
Authors: A. O. Vladutiu
Journal: JAMA (1982)

A young woman with amenorrhea had a consistently positive pregnancy test result (serum radioimmunoassay measurement of β-human chorionic gonadotropin hormone). No fetal or placental tissue was found after uterine curettage and exploratory laparotomy. The false-positive pregnancy test result was due to heterophilic antibovine and antigoat antibodies in the patient's serum. These antibodies interfered with radioimmunoassays using goat antibodies. This case shows that serum heterophilic antibodies can interfere with immunoassays and result in unnecessary diagnostic procedures and/or unnecessary treatment. (<i>JAMA</i>1982;248:2489-2490)
CONVULSIONS AFTER THERAPY FOR ALVEOLAR HYPOVENTILATION
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE STATISTIC EVIDENCES OF THE VALUE OF VACCINATION TO THE HUMAN RACE, PAST, PRESENT AND FUTURE.
Authors: EUGENE FOSTER
Journal: JAMA (1896)

<sup>30</sup>Dr. Kinnis, formerly Superintendent of Vaccination at Colombo, in his "Report on Smallpox as it appeared at Ceylon in 1833-4," and in an appendix relating to observation made by Dr. Forbes in the epidemic of 1830, gives enumerations from which the annexed table is compiled. It will be observed that the gradation of death rates marked in the last column, though far less detailed than in Mr. Marson's statement, is to the same general effect. And in the cases noticed by Dr. Kinnis himself the difference is further developed; for he distinguished persons pretending to have been vaccinated into such as had no marks, and such as had unsatisfactory marks of vaccination, and found that the death rate of the latter was 26⅓, that of the former 32 1-7. Cases of chickenpox are not included in the annexed table, and Dr. Kinnis gives at length (pp. 10-14) his reasons
Hyperlipoproteinemia in occlusive cerebrovascular disease
Authors: N. T. Mathew
Journal: JAMA (1975)

The distribution of occlusive atherosclerotic lesions in the aortocranial circulation as determined by arteriography was correlated with results of plasma lipid and lipoprotein determinations of patients with symptoms and signs of cerebrovascular disease. The incidence of hyperlipoproteinemia in the total study population was 31.8%. The frequency of hyperlipoproteinemia was significantly higher in patients with atherosclerotic lesions limited to extracranial (51%) and intracranial major vessels (44.2%) when compared to the total number of patients and patients with only intracranial small-vessel disease (P &lt;.05). Type IV hyperlipoproteinemia was the most common abnormality (extracranial group, 42% type IV, 9% type II; intracranial major-vessel group, 35.8% type IV, 8.4% type II). Patients with intracranial small-vessel disease had the lowest frequency of hyperlipoproteinemia (14.2%). The frequency of hypertension with or without hyperlipoproteinemia was higher in patients with intracranial small-vessel disease (P &lt;.01). (<i>JAMA</i>232:262-266, 1975)
Missing Byline Information in: Effects of Exercise Training on Health Status in Patients With Chronic Heart Failure: HF-ACTION Randomized Controlled Trial
Authors: M Sirajul Islam, Stanley Midzi, Alejandro Cravioto, Hubert Endtz, Munirul Alam, Mohammad Ansaruzzaman, Pra- Dip Bardhan, Shah Faruque, Anwarul Iqbal, M Shafiqul Islam, Azharul Khan, Zahid Mahmud, Ramendra Mazumder, Firdausi Qadri, Kaisar Talukder
Journal: JAMA (2009)

disk diffusion) may fail to detect strains with reduced susceptibility.Longitudinal surveillance of antimicrobial susceptibility of V cholerae O1 using quantitative (MIC) methods is therefore recommended for early detection of emergence of resistance.
What's new in the other general journals
Authors: Alison Tonks
Journal: BMJ (2006)

Sudden unexpected deaths among elite professional athletes are rare, but do professional clubs do anything to try and prevent them? The American Heart Association recommends a thorough history, family history, and physical examination for all athletes before they compete, and a survey of all 122 US teams from the basketball, hockey, football, and baseball leagues shows that most of them make a reasonable effort to identify any athletes with potentially life threatening conditions such as cardiomyopathies, Marfan's syndrome, or coronary heart disease. All the athletes in the teams surveyed were interviewed and examined every year by a team doctor, and almost all of them had blood tests for serum lipids (108/122 (89%) of teams) and an electrocardiogram (112/122 (92%)). Fewer than one in five of the teams screened their athletes using echocardiography or stress testing, however, and the most comprehensive screening strategies were reserved for elite basketball players. Credit: ANN INT MED There's only limited evidence that screening athletes actually saves lives. The best comes from Italy, where screening based on history, examination, and electrocardiography has been mandatory for all competing athletes since 1982. The incidence of sudden cardiovascular death among screened athletes in the Veneto region has since fallen from 3.6/100 000 person-years to 0.4/100 000 person-years (test for trend, P < 0.001), driven largely by fewer deaths from cardiomyopathy ( JAMA 2006;296: 1593-601). Ann Int Med 2006; 145: 507–11 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] In the outpatient setting, diagnostic mistakes that harm patients are common, complex, and deadly, according to a study of malpractice claims from four big US medical insurers. Missed, delayed, or wrong diagnoses that directly harmed the patient accounted for 59% (181/307) of all claims made by outpatients, and 30% resulted in death. Failure to take a proper history and examination, order the right test, or follow up the patient properly were the commonest diagnostic mistakes. Patients … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.issn%253D0002-9955%26rft.aulast%253DCorrado%26rft.auinit1%253DD.%26rft.volume%253D296%26rft.issue%253D13%26rft.spage%253D1593%26rft.epage%253D1601%26rft.atitle%253DTrends%2Bin%2BSudden%2BCardiovascular%2BDeath%2Bin%2BYoung%2BCompetitive%2BAthletes%2BAfter%2BImplementation%2Bof%2Ba%2BPreparticipation%2BScreening%2BProgram%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.296.13.1593%26rft_id%253Dinfo%253Apmid%252F17018804%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.296.13.1593&link_type=DOI [3]: /lookup/external-ref?access_num=17018804&link_type=MED&atom=%2Fbmj%2F333%2F7572%2F799.atom [4]: /lookup/external-ref?access_num=000240948200019&link_type=ISI
Incidence and detection of occult hepatic metastases in colorectal carcinoma
Authors: I G Finlay, C S McArdle
Journal: BMJ (1982)

Isotope liver scan, ultrasonography, and computed tomography of the liver were performed during the postoperative period in 43 consecutive patients under- going laparotomy for colorectal carcinoma.Obvious hepatic metastases were detected in six patients at the time of surgery.Eleven patients considered to have a disease-free liver at laparotomy developed hepatic metastases during the two-year follow-up period.These patients were considered to have had occult hepatic metastases at the time of surgery.Postoperative isotope liver scan, ultrasonography, and computed tomography detected the presence of overt metastases in four, five, and six patients respectively.Of the 11 patients with occult metastases, isotope liver scan, ultrasonography, and computed tomography detected one, three, and nine respectively.These observations suggest that 29% of patients under- going apparently curative resection for colorectal carcinoma possess occult hepatic metastases and that computed tomography is superior to ultrasonography and isotope liver scan in detecting them. in their detection.