tbuckley/cabot-search huggingface dataset:
Contamination and Restoration of Groundwater Aquifers
Authors: Warren T. Piver
Journal: Environmental Health Perspectives (1993)

Humans are exposed to chemicals in contaminated groundwaters that are used as sources of drinking water. Chemicals contaminate groundwater resources as a result of waste disposal methods for toxic chemicals, overuse of agricultural chemicals, and leakage of chemicals into the subsurface from buried tanks used to hold fluid chemicals and fuels. In the process, both the solid portions of the subsurface and the groundwaters that flow through these porous structures have become contaminated. Restoring these aquifers and minimizing human exposure to the parent chemicals and their degradation products will require the identification of suitable biomarkers of human exposure; better understandings of how exposure can be related to disease outcome; better understandings of mechanisms of transport of pollutants in the heterogeneous structures of the subsurface; and field testing and evaluation of methods proposed to restore and cleanup contaminated aquifers. In this review, progress in these many different but related activities is presented.
Quatre Leçons sur les Sécrétions Internes.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association News
Journal: JAMA (1933)

<h3>THE MILWAUKEE SESSION</h3><h3>Milwaukee Hotels</h3> Below may be found a list of Milwaukee hotels and rates for rooms. On advertising page 37 of this issue ofThe Journalmay be found this list together with an application form that may be used to secure reservations through the Subcommittee on Hotels of the Local Committee on Arrangements. The form that is printed in the advertising pages may be clipped and, when properly filled in, should be sent at once to Dr. Harry J. Heeb, Chairman of the Subcommittee on Hotels, 740 North Second Street, Milwaukee, Wisconsin. If those who expect to attend the annual session of the American Medical Association will send in their applications at the earliest possible time, there should be no difficulty encountered in securing satisfactory accommodations. Applicants for reservations are especially requested to include a second and a third choice in order that good accommodations may be
Occupational Disease in the Rubber Industry
Authors: John M. Peters, R. R. Monson, W. A. Burgess, L. J. Fine
Journal: Environmental Health Perspectives (1976)

We have studied mortality patterns in a large cohort of rubber workers. We have examined workers exposed to curing fumes, processing dusts, and industrial talc and have begun to evaluate exposures of these workers in detail. Gastrointestinal (especially stomach) cancer appears in excess in processing workers. Lung cancer is excessive in curing workers. Leukemia is increased generally. All three groups studied for respiratory disease have an increase in disease prevalence which is related to intensity and duration of exposure. Since both an increase in stomach cancer and respiratory disease is seen in processing workers, exposures in this area must be controlled. Since both lung cancer and chronic respiratory disease is excessive in curing rooms, this exposure must be controlled. The leukemia risk is probably related to solvents. Whether this is all explainable by past benzene exposure is unknown. Further studies are planned to refine our knowledge concerning these risks so that occupational disease in the rubber industry can be prevented.
A CASE OF DOUBLE VAGINA AND DOUBLE CERVIX
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CSIG-41. UPREGULATED EXPRESSION OF THE ARYL HYDROCARBON RECEPTOR PATHWAY IN BRAIN METASTASES FROM MALIGNANT MELANOMA
Authors: Niklas von Spreckelsen, Gabriele Röhn, Lukas Goertz, Roland Goldbrunner, Marco Timmer
Journal: Neuro-Oncology (2017)

The Aryl-hydrocarbon-receptor (AHR) is a ligand activated transcription factor linked to exogenic carcinogenic agents such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In 2011, the tryptophan (TRP) catabolite kynurenine (KYN) was identified as an endogenous ligand for AHR. The AHR is involved in several crucial processes such as cell migration, tumorigenesis, and immune function. Dysregulation of AHR, its nuclear translocator (ARNT), its repressor AHRR and the KYN building Enzyme TRP-2,3-dioxygenase 2 (TDO) has been linked to poor survival in patients with Glioblastoma. We aimed to evaluate the AHR-pathway in brain metastases. Using qRT-PCR, gene expression was analyzed in 19 brain-metastases of melanoma patients, 10 control tissues from peritumoral brain and 10 glioblastoma (GBM) samples. Differences in the expression of AHR, ARNT, AHRR, TDO as well as the AHR/AHRR ratio between tumor tissue and control were analyzed. Results are depicted in mean values with standard deviation (SD) and in Arbitrary Units (AU). p<.05 was considered significant. Both, AHR and ARNT were massively overexpressed in metastatic tissues (p<.01) (6- and 4.5-fold) in comparison to control (AHR: 3.64 ± 2.32 vs. .58 ±.50; p<0.01 and ARNT: 3.81 ± 2.25 vs. .83 ±.48, p<.01). AHRR and TDO where not significantly upregulated (.73 ±.88 vs. .41 ±.35; p=.31 and .37 ±.61 vs. .14 ±.09; p=.46). The ratio of AHR and its repressor AHRR (AHRR/AHR) was significantly different between metastases and control, hinting at a distinct regulatory imbalance (.55 ± 1.09 vs. .18 ± 1.60 p<.01). The difference of AHR expression in metastases and GBM did not quite reach significance (3.64 ± 2.32 vs. 1.27 ± 1.89; p=.055). ARNT was significantly elevated in metastases compared to GBM (3.81 ± 2.25 vs. 1.7 ±.1.15, p<.01). The AHR pathway is significantly upregulated in melanoma brain metastases and might play a pathophysiological role in growth and progression of brain metastases.
Morbid Anatomists
Authors: J. C. McClure Browne
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GFR reset point at 3 months after liver transplant is a superior predictor of liver and kidney disease related outcomes: analysis from a large cohort of NASH patients (nail NASH consortium)
Authors: Sanjaya Satapathy, Yu Jiang, Masahiko Yazawa, Miklos Z. Molnar, Tandy Agostini, Raiya Sarwar, Carlos Figueredo, Daniel Maluf, Saleh Elwir, James F. Trotter, Arul Thomas, Coleman I. Smith, MD, Danielle Brandman, Mohammad Siddiqui, Kymberly Watt, Mary Rinella
Journal: Journal of Hepatology (2020)
HEALTH IN MICHIGAN, JANUARY, 1885.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Rabies—California, 1987
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 13242: What is the Optimal Blood Pressure in Patients With Asymptomatic Aortic Valve Stenosis: The SEAS Study
Authors: Olav W Nielsen, Ahmad Sajadieh, Muhammad Sabbah, Anders M Greve, Michael H Olsen, Kurt Boman, Christoph A Nienaber, Antero Kesäniemi, Terje Pedersen, Ronnie Willenheimer, Kristian Wachtell
Journal: Circulation (2015)

Introduction: Very limited data regarding blood pressure and antihypertensive treatment in asymptomatic aortic valve stenosis (AS) have been published, and no announced consensus statement has provided recommendations for optimal blood pressure targets in this patient population. Hypothesis: Our research question was to use the best available observational data from the Simvastatin Ezetimibe in Aortic Stenosis (SEAS) trial to identify what blood pressure (BP) would be optimal in terms of mortality in asymptomatic AS. Methods: We evaluated 1798 patients with asymptomatic AS enrolled in the SEAS trial. Average follow-up BP was examined. Primary outcome was all-cause mortality, and secondary outcomes were cardiovascular death, heart failure, stroke and aortic valve replacement (AVR). Results: Average blood pressure was 144/82 mmHg and half the patients had a history of hypertension. In multivariate analysis, all-cause mortality was increased for systolic BP &lt; 120 (HR=5, p&lt;0.001), systolic 120-139 (HR=1.5, p=0.031) and diastolic BP &gt;= 90 mmHg (HR=1.9, p=0.015). Adjusting for time dependent in-between events such as aortic valve replacement, heart failure and non-fatal myocardial infarction did not significantly modify the risk. Patients at 75 years of age or more with history of hypertension had increased mortality risk with diastolic BP &gt;= 90 mmHg (HR= 3.3, p=0.004). Patients below 75 years of age with a history of hypertension had an increased risk with systolic BP &gt;= 160 mmHg (HR=2.1, p=0.049). Conclusions: In asymptomatic aortic valve stenosis all-cause mortality is lowest at a systolic BP between 140 to 159 mmHg and at a diastolic between 70 to 89 mmHg. Patients with low systolic blood pressure, in general, had increased mortality risk, and should undertake individual clinical assessment.
Constitutional Conundrums
Authors: W. M. Chapman
Journal: BMJ (1964)

sidered and the logical consequences of continued autonomy studied.In the meantime, however, local medical committees have a responsibility at the forthcoming annual elections to the General Medical Services Committee of making an exchange transfusion of new blood that is so long overdue.An opportunity to make changes that may alter the whole future of general practice is upon us.It behoves us to get the intraprofessional machinery to mould those changes efficiently.These changes must evolve slowly and we must eschew haste in the moment of crisis if we are to avoid disaster.First, therefore, let us see that machinery within our own professional organizations is efficient.-Iam, etc.,
A Student's Radiological Mathematics: Elementary Mathematics Applied to Medical Radiology.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Holistic Medicine
Authors: M. Lipkowitz
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The following brief sermon was provoked by the editorial by John P. Callan, MD, "Holistic Health or Holistic Hoax?" In contrast to the author, I gain little reassurance and much less learning from "Nobel laureates who mumble and fumble for words at meetings." There is also little to be gained from an editorial that totally confuses an appropriate approach to health care with a variety of self-serving messianistic pseudosciences. The holistic approach is simply one that recognizes that since illness is generally caused and maintained by an interaction of biologic, psychological, and social forces, attempts to alleviate it must also be directed toward these areas. A scholarly approach to this subject has been written by Engel.<sup>1</sup>Since my approach has taken the form of a sermon, I will add an exhortation. The physician who diagnoses hypertension in his patient and prescribes salt limitation and diuretics but
Campylobacter enteritis outbreaks associated with drinking raw milk during youth activities. A 10-year review of outbreaks in the United States
Authors: R. C. Wood
Journal: JAMA (1992)

<h3>Objective.</h3> —To determine the incidence of recognized outbreaks of<i>Campylobacter</i>enteritis associated with drinking raw milk during youth activities. <h3>Design.</h3> —Retrospective survey of 51 state and territorial health departments. <h3>Setting.</h3> —The 50 United States and the Territory of Puerto Rico. <h3>Populations.</h3> —Persons in preschool through college. <h3>Measurement.</h3> —Information was obtained for all<i>Campylobacter</i>outbreaks associated with consumption of raw milk during youth activities from 1981 through 1990 that were investigated by state and territorial health departments. Results.—Twenty outbreaks were identified in 11 states. Four hundred fifty-eight outbreak-associated cases occurred among 1013 persons who drank raw milk, with an overall attack rate of 45%. At least one outbreak was reported for each year of the 10-year period. Fourteen outbreaks (70%) occurred among children in kindergarten through third grade, compared with one outbreak (5%) among fourth through sixth graders. The remaining five outbreaks (25%) occurred in mixed groups of children and teenagers. Only nine (60%) of 15 outbreaks identified from 1981 through 1988 were reported to the<i>Campylobacter</i>national surveillance system maintained by the Centers for Disease Control and Prevention. <h3>Conclusion.</h3> —Drinking raw milk on school field trips or other youth activities continues despite the occurrence of multiple<i>Campylobacter</i>outbreaks documented from this practice. Such illnesses can be prevented by educating dairy farmers and officials of schools and youth organizations about the hazards of drinking raw milk. Public health organizations need to develop and implement such educational programs. (<i>JAMA</i>. 1992;268:3228-3230)
Injuries
Journal: JAMA (1989)

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Disaster Medicine
Journal: JAMA (1998)

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