tbuckley/cabot-search huggingface dataset:
Coenzyme Q10 treatment improves the tolerance of the senescent myocardium to pacing stress in the rat
Authors: Michael A. Rowland, Phillip Nagley, Anthony W. Linnane, Franklin L. Rosenfeldt
Journal: Cardiovascular Research (1998)

Objective: In elderly patients the results of cardiac interventions are inferior to those in the young. A possible contributing factor is an age-related reduction in cellular energy transduction during the intervention which may induce aerobic or ischemic stress. To investigate whether coenzyme Q10 (CoQ10) improves the response to aerobic stress, functional recoveries of senescent and young rat hearts after rapid pacing were compared with or without CoQ10. Methods: Young (4.8±0.1 months) and senescent (35.3±0.2 months) rats were given daily intraperitoneal injections of CoQ10 (4 mg/kg) or vehicle for 6 weeks. Their isolated hearts were rapidly paced at 510 beats per minute for 120 min to induce aerobic stress without ischemia. Results: In senescent hearts pre-pacing cardiac work was 74% and oxygen consumption (MVO2) 66% of that in young hearts. CoQ10 treatment abolished these differences. After pacing, the untreated senescent hearts, compared to young, showed reduced recovery of pre-pacing work, (16.8±4.3 vs. 44.5±7.4%; P<0.01). CoQ10 treatment in senescent hearts improved recovery of work, (48.1±4.1 vs. 16.8±4.3%; P<0.0001) and MVO2 (82.1±2.8 vs. 61.3±4.0%; P<0.01) in treated versus untreated hearts respectively. Post-pacing levels of these parameters in CoQ10 treated senescent hearts were as high as in young hearts. Conclusions: (1) Senescent rat hearts have reduced baseline function and reduced tolerance to aerobic stress compared to young hearts. (2) Pre-treatment with CoQ10 improves baseline function of the senescent myocardium and its tolerance to aerobic stress.
Response: Re: False-Positive Results in Cancer Epidemiology: A Plea for Epistemological Modesty
Authors: J. K. Mclaughlin, C. La vecchia, R. E. Tarone, L. Lipworth, W. J. Blot
Journal: JNCI Journal of the National Cancer Institute (2009)

ResponseWe thank Drs Cogliano and Straif for their interest in our Commentary calling for increased epistemic humility in the interpretation of new epidemiological findings on possible occupational and environmental causes of cancer.We made reference in our Commentary to two International Agency for Research on Cancer (IARC) monographs ( 1 , 2 ), not as criticisms of the monographs themselves but rather as examples of attempts to reach a consensus
Tubal infertility: an ounce of (more specific) prevention
Authors: W. Cates
Journal: JAMA (1987)

Infertility affects a relatively large number of married American couples of reproductive age.<sup>1,2</sup>In 1982, more than one in eight couples had failed to conceive after at least one year of marriage during which no contraceptives were used. That same year, nearly one in five American women between the ages of 15 and 44 years stated that they had sought professional consultation during their lifetime to increase their chances of having a baby.<sup>3</sup>Thus, by 1984, an estimated 10 million women of reproductive age had consulted physicians sometime in their lives about their infertility, approximately 1.7 million in that year alone.<sup>4</sup>
This Week in <EMPH TYPE="ITAL">JAMA</EMPH>
Journal: JAMA (2003)

A Piece of My Mind"For people employed in health care, having an ill family member creates a tension that defies resolution."From "Conflict of Interest." SEE PAGE 2521 Medical News & PerspectivesThe movement of angiogenesis inhibitors from the laboratory into the clinic has fallen short of expectations, but continuing research is leading to better understanding of the process and development of new antiangiogenic agents.
Muc-1 Core Protein Is Expressed on Multiple Myeloma Cells and Is Induced by Dexamethasone
Authors: Steven P. Treon, Joseph A. Mollick, Mitsuyoshi Urashima, Gerrard Teoh, Dharminder Chauhan, Atsushi Ogata, Noopur Raje, Joseph H.M. Hilgers, Lee Nadler, Andrew R. Belch, Linda M. Pilarski, Kenneth C. Anderson
Journal: Blood (1999)
Aging and Mental Health
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dr Todd, newly named EVP, will work for friendlier, wiser AMA
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biomagnetometry Provides a New Compass for Exploring the Brain and Heart
Authors: Andrew Skolnick
Journal: JAMA (1990)

AMONG the more than 1400 papers presented at the 75th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA), there was only one on biomagnetic imaging. Nevertheless, in the opinion of a number of radiologists there—including Derek Harwood-Nash, MD, who is the RSNA's program committee chair— this fledgling field is one of the most exciting areas in radiology today, with many potential diagnostic applications in cardiology, neurology, and psychiatry. At the next few gatherings of "the world's largest medical meeting," he expects to see many more papers on biomagnetic imaging that should provide a clearer view of what this latest round of ultra-high technology (and ultra-high cost) imaging can do for biomedical research and patient care. <h3>Detailing Electrical Activity</h3> Unlike ultrasound, computed tomography, and magnetic resonance imaging (MRI) scans (which provide anatomic information) and positron emission tomography and single-photon computed tomography scans (which show metabolic information),
Book Review Individuality of the Blood in Biology and in Clinical and Forensic Medicine . By Professor Leone Lattes, Director of the Institute of Forensic Medicine in the University of Modena, and translated by L. W. Howard Bertie, M.A., B.M., B.Ch. (Oxon.) from the French edition of 1929, thoroughly revised and brought up to date by the Author. Oxford University Press, London: Humphrey Milford. 413 Pages. Price $7.50.
Journal: New England Journal of Medicine (1933)
Locked dislocation of the metacarpophalangeal joint of the index finger
Authors: P. R. Miller
Journal: JAMA (1968)

A dislocation of the metacarpophalangeal joint of the index finger may lock in the displaced position. Eleven locked dislocations were reduced by open surgery. In all 11 cases, a portion of the torn volar plate blocked closed reduction. A good end result followed recognition of the locked dislocation and early open surgery.
Transfer of acutely ill cardiac patients for definitive care. Demonstrated safety in 755 cases
Authors: D. G. Rubenstein
Journal: JAMA (1988)

The safety of transporting acutely ill cardiac patients for cardiac catheterization has not been established. We describe 755 consecutive patients sent by ambulance from community hospitals to a tertiary center during an 18-month period. Eighty-seven percent of the patients were class III or IV New York Heart Association classification for angina. At catheterization, left ventricular dysfunction (ejection fraction &lt;55%) was present in 40%. Forty-three percent of patients required urgent intervention (coronary artery bypass surgery or percutaneous transluminal coronary angioplasty). The patients were transported by paramedic ambulance up to 99 km (≤62 miles) without a physician in attendance. No complications occurred in patients transferred within our guidelines. We believe that seriously ill cardiac patients can be transferred safely for definitive care. A single tertiary center providing immediate access to catheterization and surgical facilities can service a large population and many community hospitals. (<i>JAMA</i>1988;259:1695-1698)
A rules-based algorithm to identify patients who would benefit from re-addressing advanced care planning.
Authors: Christine M. Bestvina, Robert Michael Daly, Kristen Wroblewski, Michael Huber, Monica Malec, Selina Lai-ming Chow, Andrew Hantel, Brittany Beach, Blase N. Polite
Journal: Journal of Clinical Oncology (2017)

e21510 Background: Advance care planning (ACP) should be initiated early and readdressed often for cancer patients. We hypothesize that a rules-based algorithm based on occurrence of high-risk events can predict decreased overall survival, and can be used to target patients who would benefit from readdressing ACP. Methods: We performed a retrospective analysis of 221 patients receiving palliative chemotherapy with a diagnosis of leukemia, cholangiocarcinoma, esophageal, gastric, pancreatic, lung or urothelial cancer at the University of Chicago Medicine. Patients were included if they had an index outpatient oncology visit from April 1, 2015 through June 30, 2015. Starting at the date of index visit, we examined a three-month window for a “high-risk event,” defined as: 1. change in chemotherapy 2. emergency department visit 3. hospitalization. Patients were followed from index visit until date of death or last clinical encounter as of January 31, 2017. Each “high-risk event” was treated as a time-varying covariate in a Cox proportional hazards regression model to calculate a hazard ratio of death compared to those without an event. Results: Sixty-six percent of patients (146/221) experienced at least one high-risk event over the 3 month time frame. A change in chemotherapy regimen, an ED visit, and a hospitalization occurred in 53% (118/221), 10% (22/221) and 26% (57/221) of patients respectively. The hazard ratio of death for patients with at least one high-risk event when compared to those without was 1.86 (95% CI: 1.26-2.74, p = 0.002), when adjusted for age, gender, and race. Inpatient admission had the highest hazard of death among the high-risk events (HR 2.52: 95% CI: 1.69-3.76, p &lt; 0.001). Conclusions: The rules-based algorithm identified patients with a greater risk of death. Implementation of this algorithm in the electronic medical record can identify patients with increased urgency to readdress goals of care.
Secondary dyslipidemia. Inadvertent effects of drugs in clinical practice
Authors: Y. Henkin
Journal: JAMA (1992)

<h3>Objective.</h3> —To examine the available literature on commonly prescribed drugs and their effects on blood lipid and lipoprotein levels. <h3>Data Sources.</h3> —The review was based on searches of English-language articles from 1975 to 1990 by Medlars II and MEDLINE programs, the<i>Index Medicus</i>for 1980 to 1990, and references from identified articles. Relevant journals published within the last 6 months were also examined. <h3>Study Selection.</h3> —More than 500 articles were identified for inclusion. Articles were selected on the basis of appropriateness of design to demonstrate significant results, determined by consensus when necessary. <h3>Data Extraction.</h3> —Studies were classified according to type (observational or interventional), length of follow-up, and type of controls. Quanitative analysis of lipid, lipoprotein, and apoprotein changes induced by drugs was computed as the percentage of change observed during the course of the study (interventional) or compared with the controls at a given time (observational). <h3>Data Synthesis.</h3> —Steroid hormones that have strong progestogenic and androgenic properties, retinoids, cyclosporine A, and phenothiazines are potentially atherogenic. Steroid hormones with dominant estrogenic properties, several anticonvulsants, biguanides, high-dose ketoconazole, and aminosalicylic acid are potentially antiatherogenic. Corticosteroids appear to elevate all the lipoprotein cholesterol levels. Oral estrogens, retinoids, and corticosteroids also can elevate triglyceride levels. Other drugs with questionable effects on lipoprotein metabolism are reviewed. <h3>Conclusion.</h3> —Although the long-term implications of drug-induced lipoprotein changes are still undefined, physicians need to consider these effects in clinical practice. (<i>JAMA</i>. 1992;267:961-968)
The Bond Between Us (The Third Component)
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects in the Mouse and Rat of Prenatal Exposure to Arsenic
Authors: R. D. Hood, G. T. Thacker, B. L. Patterson
Journal: Environmental Health Perspectives (1977)

Initial experiments involving mouse development employed single IP injections of 45 mg/kg sodium arsenate on one of days 6-12 of gestation and produced a spectrum of developmental defects. Embryotoxicity was indicated by high prenatal mortality and decreased fetal weights. A chelating agent, 2,3-dimercaptopropanol (BAL), was then employed in an attempt to alleviate the adverse effects of prenatal arsenate. BAL was administered 4 hr before, concurrently with, or 4 hr after arsenate. All BAL treatments diminished arsenate-induced gross malformations and growth retardation; the concurrent treatment alleviated skeletal malformation. Injection of rats IP with arsenate has also been reported to result in teratogenicity, including renal agenesis. Further reports indicated that 40 mg/kg arsenate administered to mice by gavage on days 9–11 increased prenatal mortality, reduced fetal weights, and was associated with minor malformations. According to our recent work, however, single oral doses of arsenate must be around 120 mg/kg to cause prenatal toxicity. Multiple doses of 60 mg/kg on 3 days had little effect. Sodium arsenite has also been found to be fetotoxic and teratogenic. Such effects were seen at IP doses of 10–12 mg/kg.
Ethics Committees
Authors: Janet Fleetwood
Journal: Annals of Internal Medicine (1994)

Letters1 November 1994Ethics CommitteesJanet Fleetwood, PhD and Stephanie S. Unger, JDJanet Fleetwood, PhDSearch for more papers by this author and Stephanie S. Unger, JDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-9-199411010-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Miller and Mackler's letter illuminates the intent of the New York State Task Force on Life and the Law regarding the authority of institutional ethics committees. Although we are encouraged that the Task Force did not mean to propose giving physicians “special or automatic immunity for following the advice of an ethics committee,” we remain concerned about the clarity of their 1992 document [1].Appendix A of section 11, Bioethics review committees, part C, page 262, states: “Recommendations and advice by the bioethics review committee shall be advisory and nonbinding, except for committee approvals or disapprovals of the ...References1. New York State Task Force on Life and the Law. When Others Must Choose: Deciding for Patients without Capacity. New York: New York State Task Force on Life and the Law; 1992. Google Scholar2. American Hospital Association. New York moves to revamp policies on patients without capacity. Hospital Ethics. May/June 1993. Google Scholar Author, Article, and Disclosure InformationAuthors: Janet Fleetwood, PhD; Stephanie S. Unger, JD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1994Volume 121, Issue 9Page: 725KeywordsBioethicsHealth careHealth care providersImmunityLegislationPatients ePublished: 15 August 2000 Issue Published: 1 November 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE CHOICE OF METHODS OF BLOOD TRANSFUSION
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spirits and the Medical Mind
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuing Medical Education
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatry
Authors: Barry H. Guze
Journal: JAMA (1990)

The past decade has seen the continued growth of solid psychiatric epidemiologic studies that are relevant to disease prevalence, to disease varitions (patterns of symptoms and impairment encountered in the community), and to health care use. For the range of depressive and anxiety disorders, a small proportion of patients are seen in the specialty sector, far more in general medical settings, and a large proportion—even with the recent availability of an enlarged array of treatment options<sup>1</sup>—remain untreated. Evidence mounts for the increased medical morbidity and impairment of social performance and physical functions generated by these disorders. Continued research is needed to differentiate mood disorders and symptoms, a problem analogous to determining when a measurement of elevated blood pressure becomes a syndrome or disorder. These issues are highlighted by the initial reports from the large Medical Outcomes Study conducted by The RAND Corporation. Tarlov and associates<sup>2</sup>deliberately included