tbuckley/cabot-search huggingface dataset:
New microRNA-based diagnostic test for lung cancer classification.
Authors: T. B. Edmonston, H. Gibori, M. Kushnir, G. Lithwick Yanai, H. Benjamin, M. Bibbo, C. Thurm, L. Horowitz, Y. Huang, M. Feinmesser, I. Barshack, S. j. Hou, S. Gilad, S. Benjamin, K. Ashkenazi, M. Ezagouri, Y. Goren, C. Hogan, A. Chajut
Journal: Journal of Clinical Oncology (2011)

10531 Background: Lung cancer is the leading cause of cancer deaths in the USA. Treatment options are determined by tumor subtyping, for which there is a lack of standardized techniques. Moreover, in about 20% of cases a subclassification is not possible on preoperative specimens. MicroRNA expression profiling is a promising new strategy for the accurate subclassification of lung cancers. Using microRNA microarray data generated from over a hundred formalin-fixed, paraffin-embedded (FFPE) primary lung cancer samples, we have identified microRNA expression profiles that differ significantly for the lung cancer subtypes. Based on these findings, we present here the development and clinical validation of a microRNA-based qRT-PCR assay that differentiates primary lung cancers into four types: squamous cell carcinoma, non-squamous non-small cell lung cancer (NSCLC), carcinoid and small cell carcinoma. This assay can be used on resection specimens, small biopsies and cell blocks from cytology. Methods: Over 550 FFPE and cell blocks from different histological subtypes of lung cancer, taken from primary lung cancer resection or pre-operative diagnostic procedures, were collected. High-quality RNA was extracted from the samples using proprietary protocols. Expression levels of potential microRNA biomarkers were profiled using a sensitive and specific qRT-PCR platform. Classifiers were developed to utilize the information in microRNA expression patterns for the subclassification of lung cancers. A validation set of more than 350 independent samples were analyzed blindly and classified using the developed assay. Results: Using expression levels of 8 microRNAs in qRT-PCR, accurate classification of the lung tumors into the four above-mentioned categories could be obtained. A diagnostic assay based on this technology was developed and validated using an independent, blinded sample set. Conclusions: We identified microRNAs that represent excellent biomarkers for the classification of lung primary tumors into four categories that are relevant for patient management decisions. These findings are the basis for the development of a standardized diagnostic assay that can be used to subclassify resection specimens as well as cytology samples.
Follicular ichthyosis
Authors: M. HAZELL, R. MARKS
Journal: British Journal of Dermatology (1984)

We describe four patients with congenital follicular hyperkeratosis, of whom three also had pseudoacanthosis nigricans and two had facial abnormalities. Skin specimens were studied by light microscopy, autoradiography, histochemistry and scanning electron microscopy, and the results were compared with those from patients with keratosis pilaris. The condition appears to constitute a distinctive form of ichthyosis in which the abnormal epidermal differentiation occurs mainly within the hair follicles.
Kids Eat Their Fruits and Veggies
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiographic Density and Contrast Versus Quantity and Quality of Radiation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospitalist Care
Authors: Jerome S. Tannenbaum
Journal: Annals of Internal Medicine (2003)

Letters21 October 2003Hospitalist CareJerome S. Tannenbaum, MD, PhDJerome S. Tannenbaum, MD, PhDFrom National Nephrology Associates, Nashville, TN 37219.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-8-200310210-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The studies by Auerbach and Meltzer and colleagues (1, 2) attempted to show that the clinical experience of hospitalists improved over time and that this improvement explained the modest but statistically significant reduction in mortality, shorter lengths of stay, and lower hospital costs observed for hospitalists' patients compared with those of nonhospitalists. As the related editorial pointed out (3), the improved results in the second year of each study, most of which were related to shorter lengths of stay and lower costs, could also be attributed to improved logistic management of care, which would reflect hospitalists' increased ...References1. Auerbach AD, Wachter RM, Katz P, Showstack J, Baron RB, Goldman L. Implementation of a voluntary hospitalist service at a community teaching hospital: improved clinical efficiency and patient outcomes. Ann Intern Med. 2002;137:859-65. [PMID: 12458985] LinkGoogle Scholar2. Meltzer D, Manning WG, Morrison J, Shah MN, Jin L, Guth T, . Effects of physician experience on costs and outcomes on an academic general medicine service: results of a trial of hospitalists. Ann Intern Med. 2002;137:866-74. [PMID: 12458986] LinkGoogle Scholar3. The who, what, when, where, whom, and how of hospitalist care [Editorial]. Ann Intern Med. 2002;137:930-1. [PMID: 12458994] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From National Nephrology Associates, Nashville, TN 37219. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImplementation of a Voluntary Hospitalist Service at a Community Teaching Hospital: Improved Clinical Efficiency and Patient Outcomes Andrew D. Auerbach , Robert M. Wachter , Patricia Katz , Jonathan Showstack , Robert B. Baron , and Lee Goldman Effects of Physician Experience on Costs and Outcomes on an Academic General Medicine Service: Results of a Trial of Hospitalists David Meltzer , Willard G. Manning , Jeanette Morrison , Manish N. Shah , Lei Jin , Todd Guth , and Wendy Levinson The Who, What, When, Where, Whom, and How of Hospitalist CareHospitalist Care William Rifkin , Brad Flansbaum , and Steven Walerstein Hospitalist Care Jonathan P. Whitney Hospitalist Care Tariq Shafi Metrics Cited ByDetermining the professional attributes of a hospitalist: experience in one Australian metropolitan hospital 21 October 2003Volume 139, Issue 8Page: 703-704KeywordsDeath ratesDiagnosis related groupsForecastingHospitalistsLength of stayMortality ePublished: 21 October 2003 Issue Published: 21 October 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
American Journal of Proctology, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA Specialty Journal Abstracts
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
REMARKABLE FECUNDITY.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Soccerball-induced eye injuries
Authors: M. J. Burke
Journal: JAMA (1983)

We report a series of 24 contusion eye injuries resulting from soccerball impact. Hyphema (50%), vitreous hemorrhage (29%), corneal abrasion (21%), angle recession (8%), and retinal tear (4%) were experienced. When compared with a combined hyphema series and with hockey and racquet sports, our group had fewer serious injuries and no permanent visual acuity loss resulted. Although the incidence of eye injuries is low and the use of eye protectors may be inconvenient, we strongly recommend protective eyewear be worn in competitive sports involving large and small projectiles. (<i>JAMA</i>1983;249:2682-2685)
DIAGNOSTIC PROCEDURES
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BERNHARD von LANGENBECK (1810-1887) GERMAN SURGEON
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemic intelligence thrives on mystery
Authors: B. B. Dan
Journal: JAMA (1983)

When they race around Emory University's presidential estate, they are perhaps the most select group of cross-country runners in the world. Hailing from as far away as the jungles of Jakarta, the valleys of Ouagadougou, Upper Volta, and the streets of São Paulo, 150 entrants compete over the course. But the runner who crosses the finish line first is not the winner. Instead, in keeping with the group's precision in predicting epidemics around the world, the winner is the person who can most accurately predict his or her time over the meticulously measured 3,218.688-meter "EIS Prediction Run." EIS stands for Epidemic Intelligence Service, and the runners are all present or former members of this elite investigative corps of the Centers for Disease Control (CDC) in Atlanta (<i>JAMA</i>MEDICAL NEWS 1979;241:2776-2782). In the last few years, EIS officers have been responsible for large parts of such major achievements as determining the
Helping Russia.
Authors: S. Allard, R. Hughes
Journal: BMJ (1992)

x Values when ratings ofprofessional groups are compared with ratings of consensus panel regarding likelihood of sexual abuse Professional group x Clinical importance Specialist psychiatrists 0-780 Excellent General psychiatrists 0 567 Fair Experimental psychologists 0 705 Good Trainee social workers 0-683 Good Trainee clinical psychologists 0 661 Good Lawyers 0-717 Good Police 0 821 Excellent All groups 0 706 Good to 0 567 for general psychiatrists.The table shows the clinical importance of each of the x values according to the criteria of Cicchetti and Sparrow.IAs Harrington highlights, the levels of agreement between each group of raters and consensus are not perfect (as is true for all clinical assessments); the specialist psychiatrists and police, however, have x values that would be considered excellent levels of agreement, and only the general psychiatrists have levels of agreement below those considered to be good.We therefore stand by our original conclusions that the levels of agreement between the professional groups and the consensus panel are generally good to excellent.We also recognise, as does Harrington, that continued efforts to standardise the interview are necessary to improve the clinical assessment of children suspected of being sexually abused.We believe that our report is an important first step in that process.
“Focus on…” session: lymphoma in the elderly
Authors: S Montes-Moreno, L Odqvist, J Diaz Perez, R Pajares, J Garcı, M Mollejo, C Ruiz-Marcellan, M Adrados, N Ortiz, R Franco, M Piris, U Tirelli, L Fratino, M Balzarotti, L Uziel, A Giacalone, A Ferreri, A Santoro, M Spina, A Evens, F Hong, L Gordon, R Fisher, N Bartlett, J Connors, H Wagner, M Gospodarowicz, B Cheson, R Advani, B Kahl, R Hoppe, S Horning
Journal: Annals of Oncology (2011)
Elastin Metabolism and Chemistry: Potential Roles in Lung Development and Structure
Authors: Robert B. Rucker, Michael A. Dubick
Journal: Environmental Health Perspectives (1984)

Elastic fibers are important for elasticity and extensibility of lung tissue. In the developing lung, elastic fibers appear in greatest numbers during the process or period of alveolarization . A variety of mesenchymal cells in lung appear responsible for elastin synthesis. Elastin is a novel protein both from the standpoint of its processing into elastic fibers and chemical properties. For example, elastin undergoes posttranslational modification before its assembly into fibers. These steps include limited proteolysis, hydroxylation of prolyl residues and the oxidative deamination of lysyl residues prior to their incorporation into the crosslinks that covalently bond together polypeptide chains of elastin. The crosslinking amino acids include lysinonorleucine , merodesmosine and desmosine isomers. A key enzyme that controls this process is lysyl oxidase. Lysyl oxidase is a copper metalloprotein whose activity is responsive to and modulated by environmental insults, nutrition deficiencies and the administration of various pharmacological agents. Regarding chemical properties, elastin is one of the most apolar proteins secreted by mammalian cells. Moreover, elastin is one of the most long-lived proteins secreted into the extracellular matrix. In relationship to its processing into elastic fibers and chemical properties, details related to major aspects of elastin metabolism as well as speculation on its potential as a factor in lung development and disease are discussed.
La malattia di Heine-Medin
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ORGANIZATION SECTION
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of albumin, dextran-70 and hemaccel in the prevention of effective hypovolemia in cirrhotic patients with ascites treated with total paracentesis. A randomized multicenter study International Group for the Study of Ascites in Cirrhosis
Journal: Hepatology (1995)

A cloned stable cell line, HepG2-HBVE6, was established following transfection of HepG2 cells with a retroviral plasmid into which a 1.1-fold genomic construct of hepatitis B virus (HBV) belonging to genotype E (HBV/E) was inserted. The cell line retains the entire HBV/E insert, and produces episomal HBV DNA. It expresses HBV pregenomic, preS1 and preS2/S transcripts, and sheds hepatitis B surface and e antigens as well as structures resembling HBV-subviral and Dane particles. The HepG2-HBVE6 cell line, in permitting recapitulation of the HBV life cycle, may be used for studying viral characteristics, therapeutic and preventative outcomes and for preparing reagents specific to HBV genotype E.