tbuckley/cabot-search huggingface dataset:
Congenital Leukaemia
Authors: N. K. Pein, J. M. Garvie
Journal: BMJ (1950)

MEDICAL JOUW-I&L strapping allows the fingers to be fully flexed though the interphalangeal joints are not directly opposite each other.This method has been extensively used for all types of sprains and reduced dislocations of the fingers, and has mnore recently been found equally effective in treating stable fractures of the phalanges and metacarpals.A chronic sprain with intractable pain can be manipulated after inject- ing the affected ligament with 1 % procaine, and then splinted as for a recent sprain.
Contributions to the Art and Science of Otology.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Randomized Trial Comparing Cisplatin Plus Cyclophosphamide Versus Cisplatin, Doxorubicin, and Cyclophosphamide in Advanced Ovarian Cancer
Authors: P.F. Conte, M. Bruzzone, S. Chiara, M.R. Sertoli, M.G. Daga, A. Rubagotti, A. Conio, M. Ruvolo, R. Rosso, L. Santi, F. Carnino, M. Cottini, C. Mossetti, E. Guercio, M. Gatti, P.N. Siliquini, M.L. Prelato, C. Durando, G. Giaccone, A. Calciati, D. Farinini, M. Centonze, S. Rugiati, G. Parodi, M. Messineo, A. Storace, G. Bernardini, F. Misurale, S. Alessandri, M. Casini, N. Ragni, G. Foglia, G. Bentivoglio, G. Pescetto
Journal: Journal of Clinical Oncology (1986)

In the article by Conte et al, "A Randomized Trial Comparing Cisplatin Plus Cyclophosphamide Versus Cisplatin, Doxorubicin, and Cyclophosphamide in Advanced Ovarian Cancer" (Journal of Clinical Oncology 4:965–971, 1986), an error was made in the abstract on page 965 that altered the meaning of a sentence. The correct sentence appears below. After primary surgery, 125 patients with epithelial ovarian cancer (International Federation of Gynaecology and Obstetrics [FIGO] 1c + IIb + IIc = 22 patients, FIGO III = 82 patients, FIGO IV = 21 patients) were randomly allocated to receive PC (cisplatin 50 mg/m 2 + cyclophosphamide 600 mg/m 2 on day 1 every 28 days) or PAC (PC + doxorubicin 45 mg/m 2 ).
REBATES AND COMMISSIONS
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
First Blood
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2019)

Ad Libitum16 July 2019First BloodJack Coulehan, MD, MPHJack Coulehan, MD, MPHSetauket, New York (J.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-1490 Audio Reading - “First Blood ” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “First Blood” by Jack Coulehan Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail for AnneThe night I drew first bloodin Harlan, Kentucky,you sat perched on the edgeof our bed and offered an arm—your Elizabethan whiteto my ineptitude in green.Stretching the tourniquetabove your vein, I dabbedmy cold, moist padacross your skin. My fingersshook with lack of skilland terror that your trustwas real. When a dark streamspiraled down your arm,I lacked the sense to putsome pressure to your wound.Our rented sheets sopped upa clotted almond stain.By the time your woundturned yellow-brown,we'd traveled to the next road,around its startling turn—and learned to stem the flow,which we still do. Author, Article, and Disclosure InformationAffiliations: Setauket, New York (J.C.)Current Author Address: Jack Coulehan, MD, MPH; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “First Blood ” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “First Blood” by Jack Coulehan Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 16 July 2019Volume 171, Issue 2Page: 152KeywordsBloodRiversVeins ePublished: 16 July 2019 Issue Published: 16 July 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Applicability of the “six and twelve model” in patients with hepatocellular carcinoma treated with DEB-TACE
Authors: Maria Pipa Muñiz, Andrés Castano-Garcia, Maria Luisa Gonzalez Dieguez, Carmen Álvarez-Navascués, Valle Cadahía-Rodrigo, Susana Sanmartino, Alicia Mesa, Manuel Rodríguez, Maria Varela
Journal: Journal of Hepatology (2020)
Transcriptome analysis of paired liver biopsies identifies correlates of HBsAg response in placebo and TDF treated CHB patients
Authors: Yao-Chun Hsu, Diana Chen, Vithika Suri, Jeffrey Wallin, Jing Zhu Zhou, Cheng-Hao Tseng, Yen-Tsung Huang, Mani Subramanian, Anuj Gaggar, Ondrej Podlaha
Journal: Journal of Hepatology (2020)
Expression of high amounts of the CD117 molecule in a case of B-cell non-Hodgkin's lymphoma carrying the t(14:18) translocation
Authors: Pilar Bravo, Beatriz Díaz Agustín, Carmen Bellas, David González, Carmen Cámara, Isabel Fernández Fuertes, Julia Almeida, Ramón García Sanz, Alberto Orfao, Luis Escribano
Journal: American Journal of Hematology (2000)
Role of apolipoprotein E (ApoE) in intracellular lipid metabolism and very low density lipoprotein (VLDL) secretion by mouse hepatocytes . Groningen Institute for Drug Studies, Laboratory of Nutrition &amp; Metabolism, Groningen, *TNO-PG, Gaudius Laboratory, Leiden, **MGC-Department of Human Genetics, University of Leiden, Leiden, the Netherlands
Journal: Hepatology (1995)

Organic anion transporting polypeptides (rodent Oatp; human OATP) mediate cellular uptake of numerous organic compounds including xenobiotic toxins into mammalian hepatocytes. In the little skate Leucoraja erinacea a liver-specific Oatp (Oatp1d1, also called sOatp) has been identified and suggested to represent an evolutionarily ancient precursor of the mammalian liver OATP1B1 (human), Oatp1b2 (rat), and OATP1B3 (human). The present study tested whether Oatp1d1 shares functional transport activity of the xenobiotic oligopeptide toxins phalloidin and microcystin with the mammalian liver Oatps/OATPs. The phalloidin analogue [3H]-demethylphalloin was taken up into skate hepatocytes with high affinity (Km ∼ 0.4 μM), and uptake could be inhibited by phalloidin and a variety of typical Oatp/OATP substrates such as bromosulfophthalein, bile salts, estrone-3-sulfate, cyclosporine A and high concentrations of microcystin-LR (Ki ∼ 150 μM). When expressed in Xenopus laevis oocytes Oatp1d1 increased uptake of demethylphalloin (Km ∼ 2.2 μM) and microcystin-LR (Km ∼ 27 μM) 2- to 3-fold over water-injected oocytes, whereas the alternative skate liver organic anion transporter, the dimeric Ostα/β, exhibited no phalloidin and only minor microcystin-LR transport. Also, the closest mammalian Oatp1d1 orthologue, the human brain and testis OATP1C1, did not show any phalloidin transport activity. These results demonstrate that the evolutionarily ancient Oatp1d1 is able to mediate uptake of cyclic oligopeptide toxins into skate liver. The findings support the notion that Oatp1d1 is a precursor of the liver-specific mammalian Oatps/OATPs and that its transport properties are closely associated with certain forms of toxic liver injury such as for example protein phosphatase inhibition by the water-borne toxin microcystin.
The forgotten nodule: complications of sacral nodules in rheumatoid arthritis
Authors: Mary Shepherd, S Mary's Hospital Medical, Juliet Pm, Williams Rhys, E Oppe, M Cazabon, S Chahal, S Chaudhuri, S Chaudhury, U Chetty, Weng Chee Chew, C Davis, L Dennison, A Dhedhi, P Diwan, Elma Douglas, S Dumbuya, N Duval, J Ejeilat, M Elhawary, S El-Kalaawy, P Epstein, R Etheridge, Hannah Faal, I Farmer, M Fawzy, I Feddo, D Fernandez, M Fonta, S Gautam, P Gentle, D Gibbons, F Graham, S Guindi, A Gupta, Izhar-Ul- Haque Haffejee, D Horwell, C-S L Hsu, R Hudson, S Hunter, J Hugo, S Iqbal, Z Iqbal, M N-U Jamelle, Eleanor Jones, S Kassis, B Kaye, W Kaye, S Kayssi, G E-D, H Kazem, Y Khan, A Ladapo, R Ledward, Kee-Sheng Lee, J Legge, Keong Eng, G Lim, Yin Little, D Low, R Mackie, R Makwana, B Mammo, P Mandal, Arthur Manoranjitham, S Manuja, M Manzur, M Megahed, R Mehta, R Mifsud, A Mishra, I Modlin, B Nor, G Morritt, J Morsman, P Moses, M Muzaffaruddin, D Nadaf, A-H Naguib, S Nakhla, R Naterwalla, A Ng, K Nowak, P-C Obakponovwe, A Obiora, Siew Ogunnaike, Oh Heong, L Okujaye, L Patel, J Peacock, P Porteous, A Price, J Rajack, K Rajendran, M Ram, P Ramadasan, J Rankin, Carolyn Reid, H Rode, A Rodger, M Saad, St Rose, W Sakalo, E Schnaid, M Shafique, P Shaw, Y Sidhom, G Singh, J Singh, S Singh, M Smith, J Songo-Williams, M Souri, M Stevens, P Tivy-Jones, S Vaish, S Viswanath, A Waters, P Wellington, S Wickremasinghe, J Wright, M Yasin
Journal: BMJ (1975)
Hormone-induced bile flow and hepatobiliary calcium fluxes are attenuated in the perfused liver of rats made cholestatic with ethynylestradiol in vivo and with phalloidin in vitro*1
Authors: Y HAMADA
Journal: Hepatology (1995)

The actions of vasopressin and glucagon, administered alone or together, were assessed on bile flow in perfused livers from rats made cholestatic by the injection of ethynylestradiol and from those allowed to recover from such treatment. Concomitant measurements were made of biliary calcium output as well as changes in the perfusate Ca2+ concentration, glucose output, and oxygen uptake. Experiments were also conducted where cholestasis was induced in vitro in the perfused liver by the infusion of phalloidin. In each case cholestasis was demonstrated to have occurred by a reduction in bile flow by approximately 50%. The data show that the transient increase in bile flow and bile calcium seen in control rat liver soon after the administration of vasopressin, particularly when coadministered with glucagon, is largely absent in cholestasis induced by ethynylestradiol and attenuated in cholestasis induced by phalloidin. At the same time the pattern of perfusate Ca2+ fluxes in ethynylestradiol-induced cholestasis shifts to one reflecting net efflux of the ion from the liver. The responses to glucagon administration alone contrast with those of vasopressin in that in the perfused liver of ethynylestradiol-treated rats, glucagon induces a pronounced and sustained increase in bile flow. In cholestasis induced by both ethynylestradiol and phalloidin, glucagon fails to induce an initial transient decrease in bile flow. The effects of glucagon, including enhancement of vasopressin-stimulated bile flow in control and in ethynylestradiol-treated rats, can be mimicked by dibutyryl cyclic adenosine monophosphate (cAMP). Changes in glucose output and oxygen uptake induced by both hormones are only slightly attenuated. The data show that the modulation of bile flow that occurs rapidly after the administration of vasopressin and glucagon to control perfused rat liver is altered in conditions of cholestasis induced by either ethynylestradiol or phalloidin.
Section 7: Rheumatoid Arthritis
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coronary Occlusion and Coronary Insufficiency
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hair Casts
Authors: Peter S. Herman
Journal: JAMA (1978)

<h3>To the Editor.—</h3> I was interested in the recent article (238:2058, 1977) by Kohn regarding "Hair Casts or Pseudonits." The case that I<sup>1</sup>reported was that of a Canadian male patient with hair accretions that clinically fit the description of hair casts. Scanning electron microscopy showed the nodose accretions to be of two types— one form consisted of elliptical masses of honeycomb-like material whose exact origin was undetermined; the other consisted of cylindrical tubes of loosely-adherent cellular material consistent with the hypothesis of an abnormal retention of inner root sheath and surrounding desquamated follicular infundibulum epithelium. The photomicrographs obtained suggest that further use of the scanning microscope in analysis of this problem will be beneficial.
Allergy abstracts
Authors: David Stein Suflern, Harold Friedman, Ohio Monroe, Coleman Stamford, Conn Bridgeport, N Berger Freehold, Cleveland Ohio, Bert Kahn, Tex Andre, J Codisf, Oti Suffern, N Robert, Y Lin, New York, N Christopher, Randolph Waterbury
Journal: Journal of Allergy and Clinical Immunology (1987)
Imhotep
Authors: William H. Sprunt
Journal: New England Journal of Medicine (1955)

AS man and god, more superlatives have been spoken and written of "Dr." Imhotep than of any physician who ever lived. In justification of this writing, one more can be added: Imhotep went farther afield than any physician has ever gone.Described by Osler as the "first figure of a physician to stand out clearly from the mists of antiquity," Imhotep lived about 3000 B.C., during the reign of King Zoser, an outstanding pharaoh of the Old Kingdom of Egypt. "In priestly wisdom, in magic, in the formulation of wise proverbs, in medicine and architecture, this remarkable figure... left so . . .
Genetic Heterogeneity
Authors: Barton Childs, Vazken M. Der Kaloustian
Journal: New England Journal of Medicine (1968)

Quantitative HeterogeneityAlthough some progress is being made, it is impossible to visualize most human genetic variations in terms of differences in the amino acid sequence or of other qualities of relevant proteins. Failing that, the next best is to discover and characterize some aspect of the activity or function of such molecules. If, for example, the activity of an enzyme is reduced, several possible inferences are justifiable: an alteration of the molecule itself has reduced its efficiency; synthesis of the protein is reduced; or the reaction is inhibited in some way. It is evident that at this level of . . .
A TYPICAL ANTI-VACCINATIONIST.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatology highlights
Authors: Jean‐François Dufour
Journal: Hepatology (2016)

Covered Operation to Prevent RebleedingWhat is the best prophylactic approach to prevent rebleeding from esophageal or gastric varices in a patient with cirrhosis?One can opt for endoscopic therapy combined with a beta-blocker or consider a transjugular intrahepatic portosystemic shunt (TIPS).Data with uncovered stents are outdated with covered stent data now widely available.Early covered TIPS in selected patients at high risk for treatment failure has demonstrated survival benefit.Holster et al. randomized 72 patients with first/second episode of gastric/esophageal variceal bleeding to covered TIPS or long-term endoscopic treatment combined with a beta-blocker.As expected, early encephalopathy was more frequent post-TIPS.During the 23 months of follow-up, variceal rebleeding was significantly less frequent in the TIPS arm, but survival was equivalent in both arms; this emphasizes that the prognosis of these patients is not defined by bleeding episodes alone.(
This Week in &lt;emph&gt;JAMA&lt;/emph&gt;
Journal: JAMA (2010)

A Piece of My Mind"How do you tell a patient with metastatic renal cell carcinoma that she will get better, when every day the cancer is spreading and devouring every organ?"From "Hope." SEE PAGE 835 Medical News & PerspectivesFive years after Hurricane Katrina devastated the Gulf Coast, residents of New Orleans cope with higher than expected rates of posttraumatic stress disorder and other mental health problems.The massive British Petroleum oil spill has retraumatized many.