tbuckley/cabot-search huggingface dataset:
Book Listings
Journal: Annals of Internal Medicine (2002)

Book Listings21 May 2002Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-10-200205210-00026 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyAuscultation Skills: Breath and Heart Sounds2nd edition. Springhouse. 268 pages. Springhouse, PA: Springhouse Corporation; 2002. $50.00. ISBN 1582551588. Order phone 800-588-7738.Cardiac Arrhythmias 2001A Raviele, ed. 657 pages. New York: Springer-Verlag; 2002. $109.00. ISBN 8847001609. Order phone 800-777-4643.Cardiology: Current PerspectivesG Jackson, ed. 404 pages. Philadelphia: Taylor & Francis; 2002. $99.00. ISBN 185317629X. Order phone 800-821-8312.Catheter Ablation of Arrhythmias2nd edition. DP Zipes and M Haissaguerre, eds. 432 pages. Armonk, NY: Futura; 2002. $98.00. ISBN 0879934980. Order phone 800-877-8761.Congenital Heart Disease in the AdultWM Gersony and MS Rosenbaum. 304 pages. New York: McGraw-Hill; 2002. $99.00. ISBN 0070329095. Order ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 May 2002Volume 136, Issue 10Page: B1KeywordsComputed axial tomographyHealth careMilkPrevention, policy, and public healthRacial and ethnic issues ePublished: 21 May 2002 Issue Published: 21 May 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.Loading ...
Correction
Journal: BMJ (1962)

ANY QUESTIONS ?wash with phisophex, and a reduction in cutaneous flora in other parts of the body, from which staphylococci can be shed, could be expected if a soap medicated with hexachlorophane were provided for each nurse to use in her bath, though whether the girls would resent such an intrusion into their cosmetic and social prerogative is another matter.An alternative to the use of hexachlorophane in any of the forms referred to is thorough rinsing of the hands in 70% alcohol or in 70% alcohol containing 0.5% chlorhexidine before performing any service for an infant; Lowbury and Lilly found this to be " surprisingly effective."It is unlikely that any hand-cleansing routine, however effective against bacteria, will eliminate cross-infection in paediatric wards and nurseries, or indeed anywhere else, unless it is applied in conjunction with other measures designed to control the dissemination and spread of micro-organisms.
Neurobiology of Non-REM Sleep in Depression: Further Evidence for Hypofrontality and Thalamic Dysregulation
Authors: A. Germain
Journal: American Journal of Psychiatry (2004)

OBJECTIVE: Sleep disturbances characterize depression and may reflect the abnormal persistence of brain activity from wakefulness into non-REM sleep. The goal of this study was to investigate the functional neuroanatomical correlates of non-REM sleep relative to presleep wakefulness in depressed patients and healthy subjects. METHOD: Twelve medication-free depressed patients and 13 healthy subjects underwent polysomnography and [18F]fluorodeoxyglucose positron emission tomography scans during presleep wakefulness and non-REM sleep. Statistical parametric mapping contrasts were performed to detect differences in relative regional cerebral glucose metabolism between presleep wakefulness and non-REM sleep in each group as well as interactions across states and between groups. RESULTS: Relative to healthy subjects, depressed patients showed less of a decrease in relative regional cerebral glucose metabolism from presleep wakefulness to non-REM sleep in the left and right laterodorsal frontal gyri, right medial prefrontal cortex, right superior and middle temporal gyri, insula, right posterior cingulate cortex, lingual gyrus, striate cortex, cerebellar vermis, and left thalamus. CONCLUSIONS: Patterns of relative regional cerebral glucose metabolism changes from presleep wakefulness to non-REM sleep differ in healthy subjects and depressed patients. Specifically, the transition from wakefulness to non-REM sleep was characterized by the relative persistence of elevated metabolic activity in frontoparietal regions and thalamus in depressed patients compared with healthy subjects. These findings suggest that abnormal thalamocortical network function may underlie sleep anomalies and complaints of nonrestorative sleep in depressed patients.
<i>QuickStats:</i> Percentage* of All Emergency Department (ED) Visits<sup>†</sup> Made by Patients with Asthma,<sup>§</sup> by Sex and Age Group — National Hospital Ambulatory Medical Care Survey, United States 2014–2015
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

During 2014-2015, patients who had asthma documented in the medical record accounted for 9.5% of all ED visits in the United States, with the highest percentage for children aged 5-17 years (13.6%), compared with 6.6% for children aged 0-4 years, 9.9% for adults aged 18-64 years, and 6.5% for those aged ≥65 years. Among those aged 0-4 years, boys were more likely than girls to have a visit with asthma recorded, but for the older age groups, 18-64 and ≥65, women with asthma documented were more likely than men to have an ED visit. The difference by sex for those aged 5-17 years was not statistically significant.
Errors in Data and Statistical Significance
Authors: David Baud
Journal: JAMA (2020)

Oscar Martínez-Perez, MD, PhD; Manon Vouga, MD, PhD; Sara Cruz Melguizo, MD, PhD; Laura Forcen Acebal, MD; Alice Panchaud, PhD; Mar Muñoz-Chápuli, MD; David Baud, MD, PhD
Assessment of the Hazards of Polybrominated Biphenyls
Authors: Frederick J. Di Carlo, Joseph Seifter, Vincent J. DeCarlo
Journal: Environmental Health Perspectives (1978)

During their peak use period, PBBs represented under 1% of the total sales of fire retardant chemicals, and very probably would have escaped intensive study if they had not been mixed accidentally with animal feed preparations.Instead, international attention was drawn to PBBs by the state-supervised killing of over 35,000 cattle which had been contaminated with PBBs.Interestingly, low doses of PBBs exert a broad spectrum of toxicological, pharmacological, and biochemical effects despite low acute toxicity.These effects and the intensive bioaccumulation of PBBs derive from their structure and their consequent resistance of biotransformation and high solubility in fat.In rodents, PBBs are teratogenic, immunosup- pressive, and potentially carcinogenic.In bovine, rodent, and avian species, PBBs reduce feed intake and induce mixed function oxidases of liver microsomes.The latter effect may be responsible for steroid level changes which underline hormonal toxicities observed in cows, mink, rats, and chickens.The effects of PBBs on humans are controversial, but data suggestive of immunological, skin, and liver disorders continue to accumulate.Concern about the clinical effects of PBBs is heightened by the knowledge that these compounds readily enter the fetus by crossing the placental barrier and can be transferred to newborn children after extensive passage into breast milk.
PRACTICE AND DIPLOMA-MILLS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Rational decisions in managing sore throat: evaluation of a rapid test
Journal: BMJ (1988)

significantly higher than it had been in the initial analysis (d=2 18, p<O05).The six members of the young principals group had made 75 pulse records at one year and the 17 other principals had made 63.We did not know who had made the records in 18 cases, but assuming that they had all been made by principals who were not members of the group this gave a recording rate per principal of 12 5 for group members but 4 8 for other principals
Integrating hepatitis C virus screening by dry blood spot test into colorectal cancer screening: a randomized controlled trial
Authors: María Cristina Reygosa Castro, Felicitas Diaz-Flores, María Mercedes Dorta Espiñeira, María Luisa Galván Luis, Raquel Llada Marrero, Myriam Sánchez Pérez, Alejandro Jiménez Sosa, Enrique Quintero, José Ramón Vázquez Días, Manuel Hernandez-Guerra
Journal: Journal of Hepatology (2020)
Annales Paediatriae Fenniae, Helsinki
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cathepsin S expression is up-regulated following balloon angioplasty in the hypercholesterolemic rabbit
Authors: C BURNSKURTIS
Journal: Cardiovascular Research (2004)

Objective: Neointimal development following balloon angioplasty involves many factors including smooth muscle cell (SMC) migration and proliferation and extracellular matrix (ECM) remodeling. Further, in hypercholesterolemic (HC) conditions, there is an influx of macrophage foam cells (FCs) into the restenotic lesion, which also involves degradation of the basement membrane and surrounding ECM. The ECM remodeling that occurs during restenosis has been shown to be mediated by various proteases. Here we have investigated the role of cathepsin S (CatS), a cysteine protease, in this process. Methods and results: We have demonstrated by Taqman quantitative PCR, Western blot, and immunohistochemistry that CatS is up-regulated in restenotic lesions of HC rabbits following balloon injury of the iliofemoral artery. CatS mRNA expression was elevated 28-fold in balloon-injured vessels relative to uninjured contralateral vessels in HC rabbits 8 weeks post-angioplasty (p<0.05). CatS protein expression was detected within 1 day post-injury, persisted throughout the entire time course evaluated (60 days post-injury), and was co-localized with SMCs, macrophages, and FCs. In contrast, cystatin C (CysC), the endogenous inhibitor of cathepsins, was only minimally up-regulated following injury. CysC mRNA expression was elevated 3.5-fold in balloon-injured vessels relative to uninjured contralateral vessels in HC rabbits 8 weeks post-angioplasty (p<0.005), and up-regulation of protein expression was not detected until days 28 and 60 post-injury. Additional biochemical studies using recombinant rabbit CatS revealed that rabbit CatS digests laminin, fibronectin, and type I collagen. Further, CatS expression was evaluated in SMCs that were induced to migrate through a matrix-coated Boyden chamber upon platelet-derived growth factor (PDGF) stimulation. The addition of a selective CatS inhibitor reduced SMC migration dose-dependently with an 80% reduction in migration at 30 nM (p<0.005). Additionally, we have shown that CatS protein expression by human macrophages was increased upon stimulation with oxidized low density lipoprotein (ox-LDL), implying augmentation of CatS production during foam cell formation. Conclusion: Taken together, our results indicate an enhanced expression of CatS during neointima formation and it is associated with invading SMCs, macrophages, and FCs, highlighting the importance of CatS in the pathogenesis of restenosis.
Wings for wounded warriors
Authors: H. F. Funsch
Journal: JAMA (1967)

For the first time in history, an American casualty can be moved 8,000 miles—from the battle front to a definitive care hospital in the United States—in as little as 72 hours or less. Modern US Air Force jets need only 201/2 of those hours for the flight from Tan Son Nhut to Andrews Air Force Base, near Washington, DC. From Clark Air Base in the Philippines—where many casualties receive intensive short-term care—it is only 13 hours to the US west coast. Aeromedical flights are not limited to patients from the war in Vietnam, however. The US Air Force controls a world-wide network of aeromedical activities. Operation of that network presents some complex situations. Medical personnel must be specially trained and then positioned at the right place at the right time. Statistics on casualties and indigenous diseases help military planners decide the when and where of assignments, but the system's success
Urology
Authors: Guy W. Leadbetter
Journal: JAMA (1991)

Endoscopic urology has entered a new era. The development of a fiberoptic light source, a fine viewing lens, flexible instruments, and miniature equipment has led to a quantum leap in endoscopic diagnosis and treatment. The A. he cystoscope remains the standard for diagnosis and treatment of bladder and prostate problems. However, the flexible laparoscope and rigid and flexible ureteroscopes represent recent progress in urologic diagnosis and treatment. The laparoscope is not new; however, its use in urology is relatively recent. Indications for urologic application of the laparoscope in diagnosis and treatment are rapidly increasing.<sup>1,2</sup>The flexible laparoscope is 11 mm in diameter, and the technique for its insertion is through the umbilicus with a trocar after carbon dioxide inflation of the peritoneum. As many as three to seven ports (sheaths) are inserted when laparoscopic surgery is planned. With a small video camera on the lens, diagnostic observation or surgical
Syllabus of Materia Medica.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Dose, Dose Rate, Route of Administration, and Species on Tissue and Blood Levels of Benzene Metabolites
Authors: Rogene F. Henderson, Patrick J. Sabourin, William E. Bechtold, William C. Griffith, Michele A. Medinsky, Linda S. Birnbaum, George W. Lucier
Journal: Environmental Health Perspectives (1989)

Studies were completed in F344/N rats and B6C3F1 mice to determine the effect of dose, dose rate, route of administration, and rodent species on formation of total and individual benzene metabolites. Oral doses of 50 mg/kg or higher saturated the capacity for benzene metabolism in both rats and mice, resulting in an increased proportion of the administered dose being exhaled as benzene. The saturating air concentration for benzene metabolism during 6-hr exposures was between 130 and 900 ppm. At the highest exposure concentration, rats exhaled approximately half of the internal dose retained at the end of the 6-hr exposure as benzene; mice exhaled only 15% as benzene. Mice were able to convert more of the inhaled benzene to metabolites than were rats. In addition, mice metabolized more of the benzene by pathways leading to the putative toxic metabolites, benzoquinone and muconaldehyde, than did rats. In both rats and mice, the effect of increasing dose, administered orally or by inhalation, was to increase the proportion of the total metabolites that were the products of detoxification pathways relative to the products of pathways leading to putative toxic metabolites. This indicates low-affinity, high-capacity pathways for detoxification and high-affinity, low-capacity pathways leading to putative toxic metabolites. If the results of rodent studies performed at high doses were used to assess the health risk at low-dose exposures to benzene, the toxicity of benzene would be underestimated.
SCIENTIFIC SUPERVISION OF COMMERCIAL CLAIMS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Communication among health professionals
Journal: BMJ (1998)

Objective:To evaluate the READER model for critical reading by comparing it with a free appraisal, and to explore what factors influence different components of the model.Design: A randomised controlled trial in which two groups of general practitioners assessed three papers from the general practice section of the BMJ.Setting: Northern Ireland.Subjects: 243 general practitioners.Main outcome measures: Scores given using the READER model (Relevance, Education, Applicability, Discrimination, overall Evaluation) and scores given using a free appraisal for scientific quality and an overall total.Results: The hierarchical order for the three papers was different for the two groups, according to the total scores.Participants using the READER method (intervention group) gave a significantly lower total score (P<0.01) and a lower score for the scientific quality (P<0.0001) for all three papers.Overall more than one in five (22%), and more men than women, read more than 5 articles a month (P<0.05).Those who were trainers tended to read more articles (P<0.05), and no trainers admitted to reading none.Overall, 58% (135/234) (68% (76/112) of the intervention group) believed that taking part in the exercise would encourage them to be more critical of published articles in the future (P<0.01).Conclusion: Participants using the READER model gave a consistently lower overall score and applied a more appropriate appraisal to the methodology of the studies.The method was both accurate and repeatable.No intrinsic factors influenced the scores, so the model is appropriate for use by all general practitioners regardless of their seniority, location, teaching or training experience, and the number of articles they read regularly.
Tuberculosis - A Comprehensive International Approach
Journal: Thorax (1994)

Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematotoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6-MP) due to excessive accumulation of cytotoxic metabolites. At present, it is generally recommended that these patients should not receive AZA or 6-MP treatment for inflammatory bowel disease. We report for the first time that Crohn’s disease patients with TPMT deficiency can be successfully treated with AZA. We illustrate this with three cases where treatment has been successful and toxicity has been avoided by carefully titrating the drug dose. Thus very low TPMT activity demands pharmacogenetically guided <i>dosing</i>.
ANTIVIVISECTION PROPAGANDA BY CAMOUFLAGE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal