tbuckley/cabot-search huggingface dataset:
Diagnostic and therapeutic technology assessment. Diagnostic intraoperative ultrasound
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of the Alveolar Macrophage in Lung Injury: Studies with Ultrafine Particles
Authors: Gunter Oberdorster, Juraj Ferin, Robert Gelein, Sidney C. Soderholm, Jacob Finkelstein
Journal: Environmental Health Perspectives (1992)

We conducted a series ofexperiments with ultrfine particles (-20 nm) and larger particles (< 200 nm) of "nuisance" dusts to evaluate the involvement of alveolar macrophages (AM) in particle-induced lung injury and particle transloca- tion in rats.After intratracheal instillation of both ultrafine particles and larger particles ofTO2, we found a highly in- creased interstitial access of the ultrafine particles combined with a large acute infmmatory reaction as determined by lung lavage parameters.An additional experiment revealed that intratracheal nstillation of ph ctized ultrfine 1102 particles (inside AM) prvented both the puhonary inflam ry reaction and the interl access ofthe utrafin particles.Another experiment showed that the influx of polymorphonuclear cells (PMN) into the alveolar space unexpectedly decreased with higher doses ofultrafine particles, wheras alveolar epithelial permeability (protein leakage) increased.The divergence between PMN influx into the alveolar space and changes in alveolar epithelal permeability implies that they are separate events.Pulmonary inflammatory parameters determined by lung lavage analysis correlated best with the surface area ofthe retained particles rather than with their mass, volume, or numbers.Because higher doses resulted in an increased interstitialized fraction of particles, we suggest that inflamatory events induced by particles in the in- terstitial space can modify the inflammation in the alveolar space detectable by lung lavage.Our results demonstrate the dual role of AM for modifying particle-induced lung injury, i.e., both preventing such injury and contributing to it.We-& conclude that the increased pulmonary toxicity ofultrafine particles is related to their larger surface areaand to their in- creased interstitial access.Further, we suggest that the inte stizaon ofparticles isimportant for inducion ofpulmonary fibrotic reactions and that ultrafine particles of nuisance dusts should have different threshold limit values for occupa- tional exposure because of their increased puhnonary toxicity.
Role Of Lymphocyte Adhesion Receptors In Transient Interactions And Cell Locomotion
Authors: M. Dustin
Journal: Annual Review of Immunology (1991)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Abstract 4807: Pimavanserin suppresses pancreatic tumor growth and resistance to gemcitabine by inhibiting Akt/Gli1 signaling
Authors: Sharavan Ramachandran, Sanjay K. Srivastava
Journal: Cancer Research (2019)

Abstract Despite major advances in cancer treatment, pancreatic cancer is still incurable and the treatment outcomes are limited. In the current study, we evaluated the anti-cancer effects of pimavanserin tartrate (PVT), a drug used for the treatment of Parkinson’s disease psychosis. Our observations indicated that, PVT significantly suppressed the proliferation of pancreatic cancer cells by inducing apoptosis without exerting any cytotoxic effects in normal human pancreatic ductal epithelial (HPDE-6) cells. The colony forming ability of pancreatic cancer cells was significantly inhibited with PVT treatment. Anti-proliferative and apoptosis inducing effects of PVT were mediated by the inhibition of pAkt (Ser473), Akt, Gli1, Oct-4, SOX-2, NANOG and c-Myc. Akt and Oct-4 inhibition by PVT treatment was further validated by immunofluorescence analysis. Moreover, PVT inhibited the formation of tumorspheres in PANC1 pancreatic cancer cells. Pharmacologically inhibiting or genetically knocking out Akt or Gli1 enhanced the growth suppressive effects of PVT in pancreatic cancer cells. Subsequently, we evaluated the effects of PVT in gemcitabine resistant cells. Our results demonstrated that, PVT reduced the survival of MIAPaCa2 gemcitabine resistant cells in a concentration and time-dependent manner. Further mechanistic analysis indicated that, PVT suppressed the phosphorylation of Akt at Ser 473 and inhibited the expression of Gli1, Oct-4 and c-Myc in MIAPaCa2 gemcitabine resistant cells. Moreover, PVT increased the cleavage of caspase-3 and PARP as an indicator of apoptosis. Oral administration of PVT suppressed BxPC3 tumor xenografts by 50% in athymic nude mice. In another in vivo experiment, PVT treatment inhibited the growth of orthotopically implanted PANC1 tumors by 75%. Chronic administration of PVT did not exhibit any general signs of toxicity or behavioral side effects in mice. Taken together, our results indicate that pancreatic tumor growth suppression by PVT is orchestrated by inhibition of Akt/Gli-1 signaling. Since PVT is already available in the clinic with an established safety profile, our results will accelerate its clinical development for the treatment of patients with pancreatic cancer. Citation Format: Sharavan Ramachandran, Sanjay K. Srivastava. Pimavanserin suppresses pancreatic tumor growth and resistance to gemcitabine by inhibiting Akt/Gli1 signaling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4807.
Syphilis then and now
Authors: F. W. Marlow
Journal: JAMA (1974)

THE conclusion of 40 years as chief of the Syphilis Clinic at the Peter Bent Brigham Hospital in Boston seems to justify a brief note on the changes in treatment as well as the change in the type of disease seen in this statesupported clinic. Also, a major alteration in the epidemiological viewpoint has developed during these years. Actually, with the addition of Peter Bent Brigham Hospital internship five years earlier and the intensive introduction to syphilography under Dr. Allan K. Poole while I was a resident in the New Haven Hospital, my experience really covers almost every form of therapy since the Middle Ages—from mercury and potassium iodide to oral antibiotics. Originally,<i>arsphenamine</i>was given by intravenous drip, each treatment requiring nearly an hour, with the intravenous courses alternated with<i>mercury</i>rubs, or by intramuscularly given<i>mercuric succinamide</i>. Mercury rubs were hated by the patients because of the inevitable
The Semi-Individual Study in Air Pollution Epidemiology: A Valid Design as Compared to Ecologic Studies
Authors: Nino Kunzli, Ira B. Tager
Journal: Environmental Health Perspectives (1997)

The assessment of long-term efects of air pollution in humans relies on epidemiologic studies.A widely used design consists of cros-sectional or cohort studies in which ecologic a n of exposure, based on a fixed-site ambient monitor, is employed.Alhough health outcome'an usu- ally a large number of covarates are measured in individuals, these studies are ofien called ecolog- ical.We will inrdu the term semi-individual design for these studies.We review the major properties and limittiowithregad xto caus inrence of tr ecologic stuies, in Which out- come, exposure, and c iatesaavailable on an egate level only.Mislassification problems and issues related to unding ant model spedflcatio n truly ecologic studies limit etiologic inference to individuals.In contrast, the semi-individual study shares its methodological and inferential propeties th typical individual-level study designs.The major caveat relates to the case where too few study area, eg o or three, are used, which render conl ofaggregate kvel confounding imposble.The issue of exposure sifion is of genera concern in epidemi- ology and not an exdusive problem of the semi-individual design.In a multicenter setting, the
Black Women Make Progress in Reducing HIV Disparity
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A BETTER CONDITION OF MEDICAL AFFAIRS IN HOT SPRINGS, ARKANSAS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Revision of case definition of acquired immunodeficiency syndrome for national reporting--United States
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RESPONSE: Re: Active Tamoxifen Metabolite Plasma Concentrations After Coadministration of Tamoxifen and the Selective Serotonin Reuptake Inhibitor Paroxetine
Authors: V. Stearns, M. D. Johnson, J. M. Rae, A. Novielli, P. Bhargava, D. F. Hayes, Z. Desta, D. A. Flockhart
Journal: JNCI Journal of the National Cancer Institute (2004)
Are Environmental Sentinels Signaling?
Authors: Gerald A. LeBlanc
Journal: Environmental Health Perspectives (1995)

There is an increasing perception that environmental contamination by chemicals no longer poses a significant health threat and that relaxation of environmental regulations is warranted. However, many wildlife populations are showing signs of developmental, behavioral, and reproductive dysfunction due to environmental contamination by endocrine-disrupting chemicals. Scientists, regulators, and legislators must mobilize to identify current health threats posed by environmental pollutants, develop testing protocols that will detect such properties of new chemicals, and strengthen legislation designed to protect environmental health.
A Phase I/II National, Multi-Center, Open-Label Study of Bortezomib Plus Melphalan and Prednisone (V-MP) in Elderly Untreated Multiple Myeloma (MM) Patients.
Authors: M.V. Mateos, M. Hernández, J. Díaz Mediavilla, L. Palomera, M.J. Moro, J. Hernández, J.J. Lahuerta, J. De la Rubia, M.J. Terol, A. Sureda, J. Bargay, F. Arriba, A. Alegre, P. Rivas, J. García-Laraña, J.M. Ribera, D. Carrera, J. Bladé, F. Prósper, D.L. Esseltine, H. van de Velde, D. Schenkein, J.F. San Miguel
Journal: Blood (2005)
The cyclotron saga continues: Authors' reply
Authors: R D Errington, D Ashby, S M Gore
Journal: BMJ (1991)

mortalitv, is deliberately!misleading: the excess deaths were due to distant metastases.T! hese deaths were inevitable even before the patients entered the flawed trial.We know that this was the basis for the rejection of the study as totally inappropriate by the Radiation Therapy Oncology Group's fast neutron group in the US.So why waste time, precious resources, and the trust of patients?Yet Dr Errington and colleagues have persevered and delivered another antineutron headline.Such a headline might have been critical to the project to get a cyclotron where it would be used effectively for the benefit of patients.But this had already been torpedoed-after a brilliant, well orchestrated campaign-bv the withdrawal of what has been represented as the infamous Thatcher £6 million repayable loan-which was not a grant for cancer research, as is so often misreported, but a repayable loan for treatment.
Positive Inotropic Agents
Authors: A. Farah
Journal: The Annual Review of Pharmacology and Toxicology (1984)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Bilateral primary carcinoma of the ureter
Authors: J. Y. Gillenwater
Journal: JAMA (1966)

PRIMARY TUMORS of the ureter are uncommon, and bilateral malignant tumors of the ureter occurring simultaneously are rare. There have been previously reported only five cases of bilateral primary ureteral tumors<sup>1-5</sup>and two other cases<sup>6,7</sup>which occurred asynchronously. This case is noteworthy because of the rarity of the lesion, the paucity of presenting symptoms, the elderly age of the patient, and the concomitant finding of papillary carcinoma in the bladder. <h3>Report of a Case</h3> The patient (514124), an 81-year-old white sawmill worker, was admitted to the University of Virginia Hospital with a chief complaint of several episodes of hematuria and intermittent mild left flank pain for five months. For three years, he also had noticed increasing difficulty with urination, frequency, and nocturia (three to four times). The patient was normotensive and appeared somewhat younger than his stated age. Review of systems was non-contributory and past history was negative.
PSYCHO-THERAPEUTICS.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular anachronisms. Phrases and concepts that should disappear but haven't
Authors: M. L. Daves
Journal: JAMA (1973)

Certain cardiovascular phrases or concepts, particularly roentgenological terms, should be dispensed with because they are either erroneous, misleading, or an impediment to learning. This article discusses a partial list. The first five (cardiothoracic ratio, ventricular enlargement, water-bottle heart, straight back syndrome, straight left heart border) are impediments to the evaluation of the roentgenographic cardiac silhouette; the next two (the trachea is midline, two types of right arch) distract the learner from an understanding of the position and nature of the aortic arch; the next two (Kerley's A, B, and C lines and poor inspiratory effort) obscure relatively simple and reliable roentgenographic reflections of cardiopulmonary pathophysiology, and the last two are improper names that needlessly complicate the complicated subject of aneurysms, dissections, and ruptures. That the assertions in this article are true is substantiated bibliographically. My only contribution is a realization of the chronic learning problems attributable to the persistence of
Reference Manager
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 154: Inhibition of pancreatic cancer Panc-1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK
Authors: Unho Jin, Keshav Karki, Stephen Safe
Journal: Cancer Research (2019)

Abstract Aryl hydrocarbon receptor (AhR)-active pharmaceuticals were screened as inhibitors of pancreatic cancer cell invasion and identified two compounds, omeprazole, that inhibited invasion. Inhibition of highly invasive Panc1 cell invasion by omeprazole involves an AhR-dependent non-genomic pathway, and omeprazolemediated inhibition of Panc1 cell invasion was dependent on Jun-N-terminal kinase and mitogen-activated kinase kinase 7 (MKK7). Results of RNAseq studies indicate that omeprazole induced an AhR-dependent downregulation of several pro-invasion factors including activated leukocyte cell adhesion molecule, long chain fatty acid CoA-synthase, stathmin 3 and neuropillin 2, and the specific functions of these genes are currently being investigated. Citation Format: Unho Jin, Keshav Karki, Stephen Safe. Inhibition of pancreatic cancer Panc-1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 154.
Posters
Authors: H. Spapen, M. Diltoer, K. Delanghe, G. Ingels, L. Huyghens, C. Jones, R. D. Griffiths, R. R. Macmillan, C. Harris, S. T. Atherton, P. Nee, M. Köller, P. Wachtler, M. Senkal, M. Kemen, W. König, L. Kompan, M. M. Berger, R. Chioléro, A. Pannatier, C. Cayeux, L. Tappy, J. López Martínez, M. Sánchez Castilla, R. Díaz Abad, M. A. García Salazar, M. J. Jiménez Martín, F. Del Nogal Sáez, I. Leonard, B. Harte, J. Collier, S. Maguire, D. Phelan, Rong Xinzhou, Xiao Guangxia, Li Ao, Zhang Yaping, G. Briassoulis, S. Venkataraman, A. Thompson, R. Khorram, W. Kauhl, A. Heiden, R. Hettich, W. Behrendt, M. Bitzani, D. Matamis, K. Koletsos, N. Pondikidis, D. Botsios, D. Riggos, A. Ye. Shestopalov
Journal: Intensive Care Medicine (1996)
A hypercoagulable state does not play a major role in the development of portal vein thrombosis in patients with cirrhosis
Authors: Fanny Turon, Ellen Driever, Anna Baiges, Eira Cerda Reyes, Maria Ángeles García-Criado, Rosa Gilabert, Concepció Bru, Annalisa Berzigotti, Nuñez Isabel, Lara Orts, Juan Carlos Reverter, Annabel Blasi, Susana Seijo, Enric Reverter, Jaime Bosch, Roger Borras, Virginia Hernandez-Gea, Ton Lisman, Juan Carlos Garcia Pagan
Journal: Journal of Hepatology (2020)