tbuckley/cabot-search huggingface dataset:
The Sickbed
Authors: Robert Layzer
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Afferent Receptors
Authors: Ted McMahon
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: S B Kelly, J M Sackier, D Clarke, A J Rees, C B Wood
Journal: Gut (1992)

Small bowel haemorrhage due to cytomegalovirus vasculitis SIR,-We read with interest the report by Sackier et al (Gut 1991; 32: 1419-20) where the authors postulate a pathogenic role for cytomegalovirus in the small bowel of a patient on immunosuppressive therapy.Cytomegalovirus has been described associated with bleeding and ulceration of the upper and lower gastrointestinal tract in renal transplant recipients, although there has been no conclusive evidence that the virus is a pathogen in the gastrointestinal tract of these patients."We have recently completed a prospective study of renal transplant recipients, obtaining endoscopic biopsies of the gastroduodenal mucosa for the study of cytomegalovirus.Immunohistochemical analysis of the specimens (mouse anti cytomegalovirus monoclonal antibody, Dako Ltd, High Wycombe, Bucks) revealed evidence of virus in 16 of 33 patients (48%).The virus was detected in the duo- denum in 13 patients and in the gastric mucosa of six patients, three patients having both sites involved, and was found to involve surface epithelium and vascular endothelium.The presence of cytomegalovirus was significantly associated with histological duodenitis (p=O-00l, Fisher's exact test) and was not associated with histological gastritis or with peptic ulceration.There was no significant relationship between cytomegalovirus infec- tion and upper gastrointestinal symptoms.A prospective study by Alexander et al in liver transplant recipients reported a similar preva- lence to our own and an association with duodenitis but not with dyspeptic symptoms.4We feel that it is difficult to be certain that cytomegalovirus is a pathogen, and the histo- logical changes witnessed by Sackier and other authors may merely be a casual association, reflecting the high prevalence of the virus in immunosuppressed patients.5The vasculitis witnessed in their patient may have been because of the underlying disease process, as gastrointestinal involvement in Wegener's granulomatosis, while not common, certainly can occur.
Pollution and poverty overlap becomes issue, administration promises action
Authors: P. Cotton
Journal: JAMA (1994)

A MAP of the most polluted places in the United States is more than that. It has been known for some time that such a map is also a map of poverty, minorities, and the weakest links in the health care system. Many people in these communities complain that their concerns about this disproportionate share of pollution are ignored by physicians, researchers, and government officials. They say pollution-related diseases contribute to a cycle of poverty, and some feel that they have been targeted deliberately in what they see as "environmental racism." And while they stress that they are not opposed to properly conducted research, in many instances they feel that further study is a ruse meant to delay action. Rev Benjamin F. Chavis, PhD, DM, executive director of the National Association for the Advancement of Colored People, says that his group plans to "do more on environmental issues than we
Clinical applications of testicular radionuclide angiography and scrotal scanning
Authors: L. E. Holder
Journal: JAMA (1981)

UNTIL approximately five years ago, no imaging procedures existed to assist in the evaluation of acute scrotal swelling, with or without pain or tenderness. The introduction and development of testicular radionuclide angiography and scrotal scanning<sup>1</sup>have provided a highly reliable technique that is used primarily in the differentiation of acute epididymitis from torsion of the testis. The timely use of this procedure obviates surgical exploration, when instead antibacterial and anti-inflammatory therapy should be instituted, and points to expedient surgical intervention in the case of the salvable ischemic testis. <h3>Methods</h3> This radionuclide examination can be performed in any hospital with conventional imaging equipment. The technical details of this study have been presented elsewhere.<sup>2</sup>After careful palpation of the scrotum and localization of any swelling, the gamma camera, equipped with a converging collimator, is positioned closely over the scrotum. The entire examination can be performed in approximately 15 minutes, entailing
Paralytic Ileus
Authors: John J. Dennehy
Journal: JAMA (1963)

<h3>To the Editor:</h3> —Methocarbamol has been used since 1958 for relief of skeletal-muscle spasm. To date, serious gastrointestinal side effects have not been reported. This letter deals with a transient case of paralytic ileus which followed the therapeutic dose of methocarbamol. A 19-yr-old male was admitted to Walter Reed General Hospital with a 4-day history of increasingly severe, non-radiating, low-back pain, which began after heavy lifting. Results of urinalysis and radiologic examination of the spine were normal. The recommended therapeutic dosage of methocarbamol was administered intravenously and orally, and the patient was given codeine to relieve pain and glutethimide to induce sleep. Eight hours after ingestion of the last dose of methocarbamol, the patient began to vomit and suffered abdominal pain and tenderness. Since a chemical gastritis was believed to be responsible, meprobamate and carisoprodol were substituted for methocarbamol. Over the next several hours, abdominal distention developed and bowel sounds
Ultrasonic evaluation of intraperitoneal fluid
Authors: B. B. Goldberg
Journal: JAMA (1976)

ULTRASOUND is rapidly replacing other methods in the evaluation of intraperitoneal fluid collections. The established ability of ultrasound to readily detect fluid and differentiate it from solid makes it an ideal diagnostic examination. Since it is a noninvasive procedure, ultrasound can be used not only in the initial diagnosis but also for serial examinations once the presence of free or loculated fluid has been detected.<sup>1,2</sup>The sensitivity of ultrasound in the detection of fluid has been established experimentally: as little as 100 ml of ascitic fluid in cadavers and 300 ml in vivo has been detected.<sup>3,4</sup>This degree of resolution compares favorably to all other methods, including percussion, roentgenographic procedures, and isotope dilution examination.<sup>4</sup> Ultrasound can differentiate between free and loculated fluid. This is accomplished by simply moving the patient without changing the transducer position. Shifting of the fluid indicates that it is free. Differentiation of loculated
Exclusion of Patients from Pay-for-Performance Targets by English Physicians
Authors: Joshua Greenberg, A David
Journal: New England Journal of Medicine (2008)

therapies gain approval through FDA oversight.Also of particular interest is the discussion of the use of multimodal approaches to study the effects of anti-VEGF in normalizing the vasculature of rectal cancer.This exciting work raises questions on the role of mural cells (vascular smooth-muscle cells and pericytes) in the effect observed with antiangiogenic therapy.Although the text is thorough in the area of biologic therapies (antibodies, peptides, and viruses), less depth is afforded to the design of small-molecule inhibitors (which will probably not be missed by most readers).The topics covered in Antiangiogenic Cancer Therapy are well chosen and present the reader with balanced discussions of basic principles in vascular biology and ongoing investigations in this area.
Rectal examination and the heart.
Journal: BMJ (1969)

BRDI7UJHOHAL 319 ably owing to reinfection of persons with group A.28 Like- *wise, serological evidence shows that young persons of group o are more often infected with adenoviruses type 3 and 7 than those of group A, but in older people the difference disappears.30Hence repeated exposure of a population obscures genetically determined variations in susceptibility.In studies of volunteers exposed to influenza virus a significantly higher percentage of persons with blood group 0 than those with blood group A became infected.3'Thus there is substantial evidence that susceptibility to infection is under genetic control and that this has many -different aspects.They include destruction of invading Irganisms by leucocytes, acquired immune responses, and other constitutional factors, most of which are not yet -analysed.This is relevant not only to resistance against infection but also the maintenance of genetic diversity in populations. Mental Problems in Rheumatoid ArthritisAn important principle in medicine is to treat the sick person and not just his illness.This applies particularly to patients with chronic disability.Patients with severe rheumatoid arthritis are afflicted by a continuing disease process, which is often a worsening one.That there are important effects on the psyche is not surprising when it is considered that the disability is compounded by pain, stiffness, limitation of movement, anaemia, and generalized constitutional upset.Further problems arise as mobility decreases.There is loss of time from work, even loss of livelihood, inability to do housework, and increasing restriction of leisure activities.Personal relationships may become strained, adding to the already considerable domestic and social difficulties.In this situation patients with rheumatoid arthritis often show feel-
Regression of left ventricular hypertrophy after non-surgical septal reduction therapy for hypertrophic obstructive cardiomyopathy Wojciech Mazur, Sherif F. Nagueh, Nasser M. Lakkis, Katherine J. Middleton, Donna Killip, William H. Spencer, III. Baylor College of Medicine, Houston, TX, The Methodist Hospital, Houston, TX
Journal: Journal of the American College of Cardiology (2001)
THE RELATION BETWEEN CHILBLAINS AND TUBERCULOSIS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rubella at a Military Installation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ability of prolonged interferon treatment to suppress relapse after cessation of therapy in patients with chronic hepatitis C: A multicenter randomized controlled trial
Authors: A KASAHARA
Journal: Hepatology (1995)

The aim of this study was to determine whether 12 months course of interferon alfa (IFN-α) therapy could improve the beneficial effect of IFN in chronic hepatitis C. Eighty-eight patients were treated with natural IFN-α for either 28 weeks (45 cases) or 52 weeks (43 cases). Sustained response was achieved in 15 (33.3%) of 45 cases treated for 28 weeks and in 23 (53.5%) of 43 cases treated for 52 weeks. Transient response with relapse of alanine transaminase (ALT) after completion of therapy was observed in 13 cases (28.9%) treated for 28 weeks and in 4 cases (9.3%) treated for 52 weeks. Thus, ALT relapse was suppressed by prolonged IFN treatment. No response was found in 17 cases (37.8%) treated for 28 weeks and in 16 cases (37.2%) treated for 52 weeks, indicating that approximately 38% of the patients with chronic hepatitis C were resistant to IFN therapy even with prolonged treatment. The rate of sustained response was significantly higher in patients with type 2a or 2b than in those with type 1b. Even in type 1b cases, it was higher in the 52-week treatment group than in the 28-week treatment group, and the rate of transient response was lower in the 52-week treatment group, indicating that relapse in type 1b cases was suppressed by prolonged IFN therapy. IFN therapy was not effective for patients with advanced liver fibrosis. In multivariate regression analysis viral genotype and pretreatment level of serum hepatitis C virus (HCV) RNA were correlated independently with sustained response. Periportal necrosis, intralobular inflammation, and hepatic fibrosis scores were significantly improved in the sustained response group by IFN therapy. In the transient response group, a significant decrease in scores for intralobular inflammation and portal inflammation was observed, whereas all four histological scores were not improved in the no response group. In conclusion, prolonged IFN therapy can suppress relapse of chronic hepatitis C, even in type 1b patients. However, approximately 38% of the patients are resistant to prolonged IFN therapy, suggesting the need to develop a new therapy. (HEPATOLOGY 1995;21:291–297.)
Brain Edema
Authors: Robert A. Fishman
Journal: New England Journal of Medicine (1975)

BRAIN edema traditionally has been viewed by pathologists and clinicians as a common and often nonspecific finding in a wide variety of cerebral disorders, in association with tumors, trauma, and infections, as well as with toxic, anoxic, and metabolic disorders. In the last decade, clinical investigations and detailed laboratory studies of brain edema, using neurochemical, physiologic, and ultrastructural technics, have clarified many pathological and clinical uncertainties.1 2 3 It is now clear that cerebral edema may occur in several different forms, and that it is inappropriate to view brain edema as a single pathologic or clinical entity. This review summarizes the studies . . .
Selecting patients with decompensated cirrhosis and acute-on-chronic liver failure (ACLF) admitted to the intensive care unit for liver transplantation
Authors: Sophie-Caroline Sacleux, Faouzi Saliba, Philippe ICHAI, Marc Boudon, Elise Lemaitre, Audrey COILLY, Valérie Caillez, Rodolphe Sobesky, Eleonora De Martin, Ilias Kounis, Gabriella Pittau, Oriana Ciacio, Cyrille Feray, Daniel Azoulay, Eric Vibert, Daniel Cherqui, René Adam, Jean-Charles Duclos-Vallée, Didier Samuel
Journal: Journal of Hepatology (2020)
New myopathy with mitochondrial enzyme hyperactivity. Histochemical demonstration
Authors: R. F. Coleman
Journal: JAMA (1967)

Applicationochemical techniques to the t study of skeletal muscle biopsies has led to the description of two new clinical pathological entities.<sup>1,2</sup>The value of these techniques in the study of neuromuscular disease has been detailed and emphasized by Engel.<sup>3</sup>A third myopathy with histochemically and ultrastructurally abnormal mitochondria has been described.<sup>4,5</sup>Recently we have obtained muscle biopsies from two patients whose clinical course was characterized by the onset during the first decade of life of progressive muscle fatigability, weakness, and slight atrophy, which was more prominent in the proximal muscles. Only focal fiber generation and occasional subsarcolemmous vacuoles were seen on routine histological sections, but application of histochemical techniques clearly defined abnormal mitochondria. These mitochondria were very active enzymatically and were present in 30% to 40% of the skeletal muscle fibers from both of these patients. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 9-year-old white girl was
Prisons confront dilemma of inmates with AIDS
Authors: K. Glasbrenner
Journal: JAMA (1986)

Acquired immunodeficiency syndrome (AIDS) is not yet a major health<i>problem</i>in the nation's jails and prisons. But it has become a major<i>concern</i>of medical care officials at correctional facilities. There is good reason for concern. Inmates of penal institutions include two populations who appear to be at the greatest risk of developing AIDS—people with a history of intravenous drug abuse and males who engage in homosexual activities. Moreover, makeshift tattooing, a common practice in prisons, poses an additional risk of infection with the human T-cell lymphotropic virus type III (HTLV-III), the causative AIDS agent. And while the incidence of AIDS in prisons is not increasing precipitously, it is rising steadily. On Jan 1, 1986, there had been 455 cases of AIDS reported among inmates of federal and state prisons and 311 cases among people incarcerated in city and county jails. There are currently 144 cases among inmates incarcerated
Prognostic Relevance of Integrated Genetic Profiling in Adult T-Cell Leukemia/Lymphoma
Authors: Keisuke Kataoka, Yasunobu Nagata, Akira Kitanaka, Jun-ichirou Yasunaga, Masako Iwanaga, Yuichi Shiraishi, Kenichi Chiba, Aiko Sato-Otsubo, Masashi Sanada, Hiroko Tanaka, Hiromichi Suzuki, Yusuke Sato, Yusuke Shiozawa, Tetsuichi Yoshizato, Kenichi Yoshida, Hideki Makishima, Kisato Nosaka, Masakatsu Hishizawa, Hidehiro Itonaga, Yoshitaka Imaizumi, Wataru Munakata, Kotaro Shide, Yoko Kubuki, Tomonori Hidaka, Takuro Kameda, Tsuyoshi Nakamaki, Ken Ishiyama, Shuichi Miyawaki, Kensei Tobinai, Yasushi Miyazaki, Akifumi Takaori-Kondo, Tatsuhiro Shibata, Satoru Miyano, Masao Matsuoka, Kazuya Shimoda, Toshiki Watanabe, Seishi Ogawa
Journal: Blood (2015)
PROTECTING SCIENTIFIC RESEARCH AT THE POLLS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Belgisch Tijdschrift v Geneeskunde, Louvain
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal