tbuckley/cabot-search huggingface dataset:
AMERICAN ASSOCIATION FOR CANCER RESEARCHMeeting held at Washington, D. C., May 2, 1910
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INFANT FEEDING.
Authors: ALEXANDER McALISTER
Journal: JAMA (1903)

Both our common humanity and our public economy demand that all preventable infantile mortality be speedily prevented. That many deaths are preventable by the successful employment of known methods of feeding is clearly proven. According to a noted English statistician the present mortality among infants of his country is as high as it was fifty years ago. This is probably too gloomy an aspect to take of the subject to do justice to the facts in the case. That this statement does not apply to the American people may at least afford a measure of personal gratification; but the demands of a still too large infant mortality on our profession are none the less urgent and perennial. These demands are made on the entire profession rather than on the pediatric specialist, for, while the latter stands forth more and more conspicuously the leader in thought and action, it is
"DR. PEPYS' DIARY"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vertebral osteomyelitis due to Actinobacillus actinomycetemcomitans
Authors: I. Muhle
Journal: JAMA (1979)

ONLY 52 cases of<i>Actinobacillus actinomycetemcomitans</i>infection have been recorded from the United States and Europe.<sup>1,2</sup>Most of the patients described had endocarditis. We report here an unusual case of systemic A<i>actinomycetemcomitans</i>infection in which there was no evidence of endocarditis. This patient had vertebral osteomyelitis and axillary abscesses. To our knowledge, hematogenous osteomyelitis due to<i>A actinomycetemcomitans</i>has not been previously recognized. <h3>Report of a Case</h3> A 45-year-old accountant was in excellent health until November 1976, when he experienced lower back pain not associated with trauma, physical strain, or any systemic symptoms. Results of physical examination and urinalysis were normal. Roentgenogram of the lumbosacral spine and an intravenous urogram were normal. The patient received analgesics and physical therapy. Over the next two months, his pain worsened and at times radiated to the right hip and leg. During this period he denied fever, chills, or night sweats. By
Hepatobiliary/clinical
Journal: Gut (1994)

3rd UEGW Oslo 1994 A19 cycline (OT), and metronidazole (M).Methods: Treatment 1(101 patients): B 5 ml, OT 500 mg, and M 200 mg all q.i.d. for 14 days, Treatment 11(60 pa- tients): B 10 ml and OT 750 mg q.i.d., M 400 mg t.i.d. for 7 days, Treatment III (145 patients): B 10 ml and OT 500 mg q.i.d., M 400 mg t.i.d. for 10 days.Gastroscopy and 14C-urea breath test were performed 4 weeks and 1 year after cessation of therapy.Results: H. pylori eradication rates at 4 weeks were 87.9%, 82.1%, and 95.7% for Treatment I, lIand l1l, respectively, according to the breath test.Having re-examined 100 patients after one year with both gas- troscopy and breath test without finding any active ulcer in asymptomatic, H. pylori negative patients, we changed the protocol and did breath test only at one year in these patients.Four (all duodenal ulcer) out of 227 patients (duo- denal or pyloric ulcer 177, gastric ulcer 50), who were H. pylori negative at 4 weeks, had become H. pylori positive at one year (H.pylori recurrence rate 1.8%, 95%CI from 0.5 to 4.5%).Only one of these "reinfected" patients had ulcer relapse.Another patient had duodenal ulcer relapse shortly after ces- sation of treatment in spite of being H. pylori eradicated (ulcer relapse rate 0.9%, 95%CI from 0.1 to 3.1%).Conclusions: Following H. pylori eradication by triple therapy, H. pylori and ulcer recurrence rates are very low during the first year (below 4.5% and 3.1 %, respectively).
Radiological manifestations of ulcerogenic tumors of the pancreas. The Zollinger-Ellison syndrome
Authors: A. J. Christoforidis
Journal: JAMA (1966)

This analysis of the radiological manifestations of the Zollinger-Ellison syndrome is based primarily on thorough roentgenologic studies of 14 patients treated at the Ohio State University Hospitals where this disease syndrome was first described in 1955. The early diagnosis of this syndrome and its differentiation from benign peptic ulcer disease is of great importance in planning the curative surgical treatment. The radiological examination can provide some of the most important clues for an early diagnosis. Current knowledge of the pathological physiology of this condition has been correlated with the morphologic x-ray findings.
Exfoliative Cytology
Authors: Howard Ulfelder
Journal: New England Journal of Medicine (1949)

THE past eight years have witnessed widespread revival of the study of body fluids as an adjunct in the detection of cancer. The focus of attention in these fluids has been on the cellular constituents — the cells that have become separated from body surfaces by the natural process of desquamation. An apt phrase, "exfoliative cytology," has been coined by Papanicolaou to describe this field of investigation. It is eminently fitting that he should be the one to do so, for Papanicolaou's original painstaking observations are the firm foundation on which this science has been built.Sporadic attempts to use . . .
Estimating Contraceptive Needs and Increasing Access to Contraception in Response to the Zika Virus Disease Outbreak — Puerto Rico, 2016
Authors: Naomi K. Tepper, Howard I. Goldberg, Manuel I. Vargas Bernal, Brenda Rivera, Meghan T. Frey, Claritsa Malave, Christina M. Renquist, Nabal Jose Bracero, Kenneth L. Dominguez, Ramon E. Sanchez, Carrie K. Shapiro-Mendoza, Blanca R. Cuevas Rodriguez, Regina M. Simeone, Nicki T. Pesik, Wanda D. Barfield, Jean Y. Ko, Romeo R. Galang, Janice Perez-Padilla, Kara N.D. Polen, Margaret A. Honein, Sonja A. Rasmussen, Denise J. Jamieson
Journal: MMWR Morbidity and Mortality Weekly Report (2016)
From the editors
Authors: Lucy Bird, Olive Leavy, Kirsty Minton, Yvonne Bordon, Maria Papatriantafyllou, Isabel Woodman, Yukie Ozawa, Catriona Rodwell, Man Tse, Lucie Wootton, Lewis Packwood, Simon Bradbrook, Susanne Harris, Vicky Summersby, Patrick Morgan, Kirsten Lee
Journal: Nature reviews. Immunology (2011)
In This Issue
Journal: Circulation Research (2010)

PKC␣ C-Terminal Fragment and Cardiomyopathy (p 903)A suspected degrader of protein kinase C, in fact, liberates the active subunit of the kinase, which wreaks havoc in ischemic hearts, report Kang et al.Activation of protein kinase C (PKC) is calcium dependent and normally occurs in response to receptor signaling events.Calcium also activates a protease called calpain 1 that cleaves PKC.Thus, it was thought that calcium both induced PKC signaling and then switched it off by calpain-mediated degradation.According to a new study by Kang et al, however, calpain is not the off-switch.Calpain cleaves PKC in two, releasing the catalytically active C-terminal from the regulatory N-terminal.Far from degrading the enzyme, this cleavage unleashed the C-terminal's unfettered activity, say the authors.They made their discovery by looking in ischemic heart tissue of mice that overexpressed calpain.Ischemia prompts a dramatic rise in intracellular calcium levels and, thus, boosts the activities of PKC and calpain.Overexpression of calpain under ischemic conditions led to increased PKC cleavage, as well as to increased myocardial injury.The increased abundance of the active C-terminal caused hyperphosphorylation of normal PKC targets, as well as phosphorylation of many atypical proteins, which might be responsible for the increased ischemic damage.Drugs designed to inhibit PKC activity might, therefore, work best if aimed at the C-terminal, says the team.
The gene number dilemma: direct evidence for at least 19,000 protein-encoding genes in Caenorhabditis elegans and implications for the human genome
Authors: David E. Hill, J. Reboul, P. Vaglio, N. Tzellas, C. Jackson, T. Moore, Y. Kohara, J. Thierry-Mieg, D. Thierry-Mieg, J. Hitti, L. Doucette-Stamm, J. Hartley, G. Temple, M. Brasch, D.E. Hill, M. Vidal
Journal: Nature Genetics (2001)
Abstracts
Journal: Annals of the Rheumatic Diseases (1959)

A statistical analysis is presented of the clinical features of the primary attack of rheumatic fever as seen in 206 consecutive cases admitted to the Paediatric Clinic of the University of Florence during the period 1947-57, particular reference being made to the incidence of atypical or "minor" manifestations.The incidence of the disease was highest (157 cases) between the ages of 6 and 11 years, while the seasonal incidence was highest from September to November and lowest in August.In 157 of the 206 cases, the clinical picture was typical, with involvement of the joints (during the first week in 134 cases and between the 2nd and 4th weeks in 23).In the remaining 49 cases (23 -78 per cent.), the onset was marked by atypical symptoms involving the digestive or respiratory tract or the nervous system, making an accurate and early diagnosis difficult.In 22 of these 49 cases the patient complained of severe abdominal pain suggesting an acute surgical condition and in eight the clinical picture resembled pneumonia, bronchopneu- monia, or pleurisy.In 21 cases the only symptom was a rise in temperature, sometimes associated with a sore throat.The authors are of the opinion that tonsillectomy is of no real value in the prophylaxis of rheumatic fever and may even precipitate an attack.In 21 of their cases rheumatic fever developed despite the fact that the tonsils had been removed, and in four of these cases the operation had been performed within 15 to 30 days of the onset of the attack.In view of the high incidence of atypical forms of acute rheumatism they recommend the institution of "precautionary" treatment with anti- rheumatic drugs and antibiotics in all cases in children of indeterminate febrile illness which might be of rheumatic aetiology.
Table of contents
Journal: Hepatology (2019)

Cover Figure : Yes-associated protein (YAP) is a transcriptional co-activator that plays a major role in liver size regulation.Bi and colleagues established that activation of pregnane X receptor (PXR), a transcription factor integral to xenobiotic and endobiotic metabolism, caused mouse hepatic enlargement.PXR was found to interact with the YAP signaling pathway, indicating a function for PXR in controlling liver size and determining liver cell fate via the YAP signaling pathway.
Comparison of long-term results of endoscopic video-assisted breast surgery (VABS) between transaxillary retromammary approach (TARM) and periareolar approach.
Authors: Koji Yamashita, Shunsuke Haga, Kazuo Shimizu
Journal: Journal of Clinical Oncology (2012)

1112 Background: The breast conserving surgery (BCS) and the sentinel node (SN) biopsy became to be recognized as the standard treatment for early breast cancers. We have reported about cosmetic effectiveness and lower infestation of the video-assisted breast surgery (VABS) for the breast diseases. We devised the trans-axillary retro-mammary (TRAM) approach of VABS. It needs only one skin incision in the axilla and can treat any tumor of the breast without making any injuries on the breast skin. We evaluated the aesthetic results and the curability of this surgical method. Methods: We have performed VABS on 300 patients since December, 2001. The newly devised TARM was performed on 120 patients of early breast cancer, stage I and II. After endoscopic SN biopsy, we elongated the axillary skin incision to 2.5 cm. We dissected major pectoral muscle fascia to detach retromammary tissue behind the tumor. We cut the mammary gland with clear surgical margin, and removed it through the axillary port. The breast reconstruction was made by filling absorbable oxydized cellulose. The postoperative aesthetic results were evaluated by ABNSW. Results: BCS was performed on 286 patients (26 after preoperative chemotherapy) and skin-sparing mastectomy on 14. There was no serious complication after surgery. Surgical margin was minimally positive in 2. The original shapes of the breast were preserved well. The follow-up is 126 months at maximum and 74 months on average. There is 3 locoregional recurrences and 14 distant metastases. 5-year survival rate is 97.3%. With regard to TARM, The skin incision only in the axilla made better looks and shapes of the breast. It could be applied for tumors in any area of the breast without tumor nipple extension. The reconstruction with oxidized cellulose needs no excessive detachment of the skin beyond the surgical margin. The postoperative esthetic results were excellent and better. The sensory disturbance was minimal. All patients expressed great satisfaction. Conclusions: VABS can be considered as a good surgical procedure concerning locoregional control and esthetics. TARM is better on the patients without tumor nipple extension.
Levels of Methyleugenol in a Subset of Adults in the General U.S. Population as Determined by High Resolution Mass Spectrometry
Authors: Dana B. Barr, John R. Barr, Sandra L. Bailey, Chester R. Lapeza, Michelle D. Beeson, Samuel P. Caudill, Vincent L. Maggio, Arnold Schecter, Scott A. Masten, George W. Lucier, Larry L. Needham, Eric J. Sampson
Journal: Environmental Health Perspectives (2000)

We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detection is 3.1 pg/g and its average coefficient of variation is 14% over a 200-pg/g range. We applied this method to measure serum ME concentrations in adults in the general U.S. population. ME was detected in 98% of our samples, with a mean ME concentration of 24 pg/g (range &lt; 3.1-390 pg/g). Lipid adjustment of the data did not alter the distribution. Bivariate and multivariate analyses using selected demographic variables showed only marginal relationships between race/ethnicity and sex/fasting status with serum ME concentrations. Although no demographic variable was a good predictor of ME exposure or dose, our data indicate prevalent exposure of U.S. adults to ME. Detailed pharmacokinetic studies are required to determine the relationship between ME intake and human serum ME concentrations.
JAPAN
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hexylresorcinol as General Antiseptic.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
QUARANTINE.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Costs vs quality in different types of primary care settings
Authors: B. Starfield
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine the relationship between efficiency in use of resources and quality of care provided by physicians serving as the usual source of care for patients in a state Medicaid program. <h3>Design.</h3> —Retrospective quality-of-care review of 2024 outpatient medical records of 135 providers sampled from system-wide Medicaid claims data in Maryland. <h3>Subjects.</h3> —Providers in three types of practice settings (hospital outpatient clinic, community health center, and physician's office) were stratified into three case mix—adjusted resource use groups (high, medium, and low). A sample of patients with the diagnoses of diabetes, hypertension, asthma, well-child care, or otitis media were identified from Medicaid claims forms from visits during 1988. Case mix was controlled by the application of the ambulatory care groups, a method that characterizes populations according to their burden of morbidity. <h3>Main Outcome Measures.</h3> —Nurses from the local peer review organization audited medical records using explicit criteria for quality of care in several categories: evidence of impaired access, evidence of compromised technical quality, evidence of inappropriate care, outcome of care, and several generic indicators of quality. Well-adult care was assessed for patients with the adult diagnoses. <h3>Results.</h3> —Although there were some systematic differences by type of facility in some aspects of quality of care (more access problems for patients in hospital clinics and more technical quality problems for patients in office-based practice), there were no consistent differences in quality of care overall for patients in different types of settings and no consistent relationships between cost-efficiency and quality of care. However, patients in medium-cost community health centers had the best or second best scores for most of the 21 comparisons of type of quality assessed. <h3>Conclusions.</h3> —Quality of care provided for common conditions in primary care is not associated with costs generated by providers. Policies directed toward the choice of low-cost vs high-cost providers will not necessarily lead to a deterioration in the quality of care. States can both improve quality and lower costs by consistent monitoring of programs over time. The finding of generally higher quality of care for patients in medium-cost community health centers deserves further study. (<i>JAMA</i>. 1994;272:1903-1908)