tbuckley/cabot-search huggingface dataset:
Abstract 3558: Time of Day: A Vital Determinant in Diet-Induced Cardiometabolic Syndrome Development
Authors: Molly S Bray, Ju-Yun Tsai, Brandon Boland, Michael Kueht, Oluwaseun Egbejimi, Zachary Blasier, Rebecca Kelly, Jason Zoller, Martin E Young
Journal: Circulation (2008)

Excess caloric intake is strongly associated with the development of obesity, type 2 diabetes mellitus, and cardiovascular disease (CVD). Research efforts have focused attention primarily on the quality (i.e., nutritional content) and/or quantity of calories as potential causes for diet-induced pathology. Little is known regarding how the timing of nutrient ingestion influences CVD development, despite growing acceptance that biological rhythms strongly affect cardiovascular physiology and pathophysiology. We therefore hypothesized that the time of day at which dietary fat is consumed profoundly influences the development of the cardiometabolic syndrome. Mice were initially fed either control or high fat diets (10% and 45% calories from fat, respectively) in an ad libitum fashion. As expected, 16 weeks ad libitum high fat feeding resulted in increased body weight gain (13%), increased percent body fat (23%), increased ventricular weight (11%), and myocardial contractile dysfunction (33% decrease in cardiac power, as assessed in ex vivo working mouse heart perfusions), relative to control mice (p&lt;0.05). A separate set of mice were next fed only during the 12hr active/awake/dark phase, and were divided into early fat (EF) and late fat (LF) groups (access to high fat diet only during the first 4 hours versus the last 4 hours of the active phase, respectively; mice were allowed access to control diet for remaining active phase hours). LF feeding resulted in increased body weight gain, increased percent body fat, decreased glucose tolerance, decreased skeletal muscle oxidative capacity, induction of myocardial anf expression, and decreased cardiac power, relative to EF feeding, despite virtually identical quantity and quality of calories consumed (see Table ). These data reveal that the consumption of dietary lipids during the end of the active phase (i.e., dinner for humans) significantly contributes to diet-induced cardiometabolic syndrome development.
BOOK REVIEWS
Authors: W. P. McGUIRE
Journal: JNCI Journal of the National Cancer Institute (1989)

BOOK REVIEWS Get access Multimodal Treatment of Ovarian Cancer. Pier Franco Conte, Nicola Ragni, Riccardo Rosso, Jan B. Vermorken, eds. New York: Raven Press, 1989, 350 pp. $89. WILLIAM P. McGUIRE WILLIAM P. McGUIRE Medical Oncology The Johns Hopkins Oncology Center600 N. Wolfe St. Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 12, 21 June 1989, Pages 958–959, https://doi.org/10.1093/jnci/81.12.958 Published: 21 June 1989
BOOK REVIEW
Authors: R. SIKORSKI
Journal: JNCI Journal of the National Cancer Institute (1995)

BOOK REVIEW Get access Cancer: a Molecular Approach . Nicholas Lemoine , John Neoptolemos , Timothy Cooke , eds. Oxford : Blackwell Scientific Publications , 1994 . 383 pp., illus. $125. ISBN 0-632-03511-0 ROBERT SIKORSKI, M.D., PH.D ROBERT SIKORSKI, M.D., PH.D Howard Hughes Medical Institute Fellow Varmus Laboratory Bldg. 49, Rm. 4A56 National Cancer InstituteBethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 2, 18 January 1995, Page 140, https://doi.org/10.1093/jnci/87.2.140 Published: 18 January 1995
Transplantation of the liver.
Journal: BMJ (1968)

PointersLiver Transplantation: Account of organiza- tional and technical difficulties which limit success.Cooling donor liver within 15 minutes of death is important (p. 535); Two cases of primary liver cancer treated by transplantation.Immunosuppressive therapy is considered to have been of value (p. 541); Leader at p. 529.Folate Compounds: Polyglutamate forms com- prise about three-quarters of folate in normal diet, and studies indicate these to be absorbed and utilized to only one-third of the extent of simpler forms (p.546).Penicillin " Side Effect": Massive dosage of sodium penicillin in three cases considered responsible for potassium excretion, the drug acting as a non-reabsorbable anion (p. 550).Assaying A.C.T.H.: Radioimmunoassay re- ported to be satisfactory method for determining plasma levels in Cushing's syndrome (p. 552).Pulse Detection: Ultrasonic flow velocity detector proved a reliable indicator of distal limb pulses (p. 555).Synovitis of Hip: Virological study fails to con- firm that transient synovitis in children is caused by viral infection (p. 557).Case Reports: Local anticoagulation (p.558) Toxoplasmosis and myocarditis (p.559).Organic Psychosis: Illustrative cases (p. 561).Today's Tests: For amyloidosis (p. 564).Diagnostic Neuroradiology: Retrospective study suggests plain x-rays do not contribute materially to diagnosis in majority of cases (p.569).
The Lethal War Gases: Physiology and Experimental Treatment. An Investigation by the Section on Intermediary Metabolism of the Medical Division of the Chemical Warfare Service at Yale University under the Direction of Frank P. Underhill, Professor of Experimental Medicine, School of Medicine, Yale University. Published with the Permission of the Director of the Chemical Warfare Service.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A DISREGARDED SOURCE OF SURGICAL INFECTIONS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Removal of phenytoin by hemodialysis in uremic patients
Authors: E. Martin
Journal: JAMA (1977)

The removal of phenytoin by hemodialysis was determined in seven uremic patients. Four patients were receiving phenytoin sodium for therapeutic purposes; three received one dose each intravenously to quantitate its disposition in uremia. The drug was measured in whole blood, plasma, saliva, and dialysate. Only 2% to 4% of the intravenous dose was recovered in the dialysate. Phenytoin clearance by dialysis was 7 to 14 ml/min; plasma clearance was 53 to 133 ml/min. Since hemodialysis contributes little toward shortening the 11-to-18-hour half-life of phenytoin in the uremic patient, no supplemental dose is necessary for uremic patients undergoing hemodialysis. (<i>JAMA</i>238:1750-1753, 1977)
Dermatology
Authors: John G. Downing
Journal: New England Journal of Medicine (1949)

BloodMycosis fungoides fortunately is a comparatively rare disease. Hence, there are a limited number of cases in the various reports on therapy. Henstell68 reports that, irrespective of the stage, 6 cases responded immediately to nitrogen mustard. All were radioresistant. Cases with a prolonged premycotic stage showed the best response. In my opinion most follow-up examinations have shown that the improvement has been temporary.Law69 states that tumor formation in mice with transplanted leukemia responded favorably to urethane.In a paper on the treatment of neoplastic disease with nitrogen mustard, Taffel70 reports the results of 16 cases (6 cases of . . .
A multimodal intervention to enhance sexual function and quality of life (QOL) in hematopoietic stem cell transplant (HCT) survivors.
Authors: Sarah Fishman, Julie Vanderklish, Don S. Dizon, Lara Traeger, Elyse R. Park, Yi-Bin Albert Chen, Steven L. McAfee, Thomas R. Spitzer, Zachariah Michael DeFilipp, Jennifer Temel, Areej El-Jawahri
Journal: Journal of Clinical Oncology (2017)

10013 Background: Although sexual dysfunction is a common long-term complication in allogeneic HCT survivors, interventions to address sexual dysfunction are lacking. Methods: We conducted a pilot study to assess the feasibility and preliminary efficacy of a multimodal sexual dysfunction intervention to improve sexual function in allogeneic HCT survivors. Transplant clinicians systematically screened all HCT survivors ≥ 3 months post-HCT for sexual dysfunction causing distress using the NCCN Survivorship Guidelines. Those who screened positive attended monthly intervention visits with trained study clinicians that focused on 1) assessing sexual dysfunction; 2) educating and empowering patients to address this topic; and 3) implementing therapeutic interventions. We used the PROMIS Sexual Function and Satisfaction Measure, Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT), and Hospital Anxiety and Depression Scale (HADS) to assess sexual function, QOL, and mood at baseline and six months post-intervention, respectively. Results: 32.7% (49/150) of patients screened positive for sexual dysfunction causing distress. 95.9% (47/49) of patients who screened positive agreed to participate. We demonstrated significant improvement in patients’ satisfaction and interest in sex as well as sexual function including orgasm, erectile function, lubrication, and vaginal discomfort [Table]. Six of ten patients who were not sexually active prior to the intervention became sexually active post-intervention (P = 0.031). Patients reported improvement in their QOL and a trend toward lower depression [Table]. Conclusions: The multimodal intervention to address sexual dysfunction appears feasible with encouraging preliminary efficacy for improving sexual function, QOL, and mood in allogeneic HCT survivors. Clinical trial information: NCT02492100. [Table: see text]
Multiple myeloma. A community cluster
Authors: R. A. Kyle
Journal: JAMA (1970)

In 1968, multiple myeloma was diagnosed in six residents of a Minnesota community (population 7,151). This is a rate of 84 per 100,000, as compared with an expected rate of about 3 per 100,000. The clinical and laboratory features of these cases were typical of myeloma. In addition, one case of Waldenström's macroglobulinemia was found during this period. The incidence of other forms of leukemia and lymphoma and of congenital malformation was not increased in the town during the years 1960 through 1968. The cause of this apparent community cluster of multiple myeloma cases remains obscure.
THE INORGANIC ELEMENTS IN THE BLOOD
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FACTORS INFLUENCING ABNORMAL GLAND MORPHOGENESIS IN COLORECTAL CANCER (CRC)-TRANSLATIONAL STUDIES
Authors: R Topley, I Jagan, R K Deevi, A Fatehullah, J Eves, M Stevenson, M Loughrey, K Arthur, F C Campbell
Journal: Gut (2013)

<h3>Introduction</h3> Disruption of colorectal gland formation characterizes high grade, aggressive CRCs but causal mechanisms remain unclear. Glandular morphogenesis can be modelled in three-dimensional (3D) culture systems that enable investigation of specific oncogenic signals. We have shown that the tumour suppressor PTEN regulates 3D glandular morphogenesis in a Caco-2 colorectal organotypic model system through effects on the Rho-GTPase cdc42. Cdc42 is activated by specific guanine nucleotide exchange factors (GEFs) and influences gland lumen formation by regulation of apical membrane (AM) assembly. PTEN knockdown inhibits cdc42, disrupts AM integrity and induces a vacuolar, multilumen glandular phenotype evocative of high grade CRC. While PTEN has catalytically -active or -inactive functional domains relevant to phosphatidylinositol 3-kinase (PI3K) activity, Caco-2 gland development was unaffected by PI3K signalling. <h3>Aims/Background</h3> Study aims were to investigate effects of PTEN PI3K catalytically -active or -inactive functional domains on 3D Caco-2 morphogenesis and to assess model fidelity to human CRC. <h3>Method</h3> We used wild type PTEN-expressing Caco-2 cells and isogenic stable PTEN knockdown Caco-2 (KD) clones in two- (2D) and three-dimensional (3D) cultures as model systems. Cell membrane localization of specific cdc42 GEFs was investigated by cell fractionation and immunoblot. Effects of catalytically -active or -inactive PTEN mutants on cdc42 activity and/or AM integrity during 3D morphogenesis were investigated by transfection and confocal microscopy. Apical membrane integrity was assessed in human CRC by semiquantitative score of the AM marker, NHERF-1. CRC gland morphology was assessed by a validated grading system. <h3>Results</h3> PTEN expression enhanced cell membrane recruitment of cdc42 GEFs with a specific role in 3D morphogenesis (Tuba, ITSN2). PTEN mutants containing an intact catalytically-inactive C2 domain enhanced cdc42 activity, restored AM integrity and rescued defective morphogenesis of 3D PTEN-KD Caco-2 cultures. Conversely, a C2 domain construct mutated at its CBR3 lipid-binding motif was ineffective. Fundamental attributes of the model system viz, associations between AM integrity and gland morphology were conserved and had prognostic significance in human CRC. <h3>Conclusion</h3> PTEN deficiency impairs GEF membrane recruitment, cdc42 activation, apical membrane assembly and CRC glandular morphogenesis in a predictive colorectal cancer model system. Dissection of these networks may identify molecular targets for novel therapy, aimed at high grade CRC.
Book Review Hayfever Plants: Their appearance, distribution and time of flowering, and their role in hayfever, with special reference to North America. By Roger P. Wodehouse, Ph.D. 4°, cloth, 245 pp., with 73 illustrations. A publication of the Chronica Botanica Company, Waltham, Massachusetts. New York City: G. E. Stechert and Company, 1945. $4.75.
Journal: New England Journal of Medicine (1946)
Abstract 19532: Maternal Hyperoxia Increases Cerebral Oxygenation in Fetuses With Complex Congenital Heart Disease: A Functional MRI Study
Authors: Wonsang You, Mary Donofrio, David Wessel, Zungho Zun, Josepheen De Asis-Cruz, Gilbert Vezina, Dorothy Bulas, Richard Jonas, Adre du Plessis, Catherine Limperopoulos
Journal: Circulation (2015)

Introduction: Fetal brain growth is altered in congenital heart disease (CHD). The role of disturbed placental and fetal blood flow/oxygenation remains poorly understood. We compared the effect of maternal hyperoxia on cerebral and placental oxygenation in CHD vs control fetuses using blood oxygenation level dependent (BOLD) functional MRI (fMRI). Methods: We studied 85 pregnant women (51 healthy /34 CHD fetuses) at 22-39 weeks gestational age (GA), using MRI and Doppler. After 2min baseline recording at normoxia (NO), we made BOLD fMRI measurements in 4 phases, (1) early hyperoxia (HO; 100% O2) for 2min (2) late HO (2min), (3) early return NO (1.75min), (4) late return NO (1.75min). We measured % BOLD signal changes in fetal brain and placenta and correlated these with umbilical artery (UA) pulsatility index (PI) obtained at baseline. Results: Mean GA of CHD vs control fetuses was 32 4/7 and 32 2/7 (p=0.77). 41.2% had 1-ventricle (1V; all HLHS) vs 2-ventricle (2V) physiology. In controls, brain BOLD signal increased in phase 1 HO and remained elevated through phase 4. In CHD fetuses, the BOLD signal increased in phase 1 and continued to rise through phase 4. Differences in brain BOLD elevation in CHD vs controls (3.1% vs 0.9%, p=0.04) was significant in phase 4 (Fig. 1). Brain BOLD differed between 1V (3.4%, p=0.04) and 2V (0.9%, p=0.15) in phases 3 &amp; 4. Placental BOLD signal increased during HO in control (4.4%, p&lt;0.001) and CHD fetuses (6.4%, p&lt;0.001). UA PI in CHD fetuses was higher than controls (1.11 vs 1.03, p=0.03). UA PI correlated with placental BOLD during HO in healthy and CHD fetuses (p&lt;0.05). Conclusions: In this first report of placental and fetal brain responses to maternal HO, we show a significantly increased brain BOLD response in CHD fetuses, specifically 1V. These data suggest that maternal HO improves brain oxygenation in CHD fetuses in the short-term. Studies evaluating the prolonged effects of HO are needed to determine the role of HO management in select CHD fetuses.
Insulin-Stimulated Increase in Serum Leptin Levels Precedes and Correlates with Weight Gain during Insulin Therapy in Type 2 Diabetes
Authors: Anne-Marie Aas, Kristian F. Hanssen, Jens Petter Berg, Per M. Thorsby, Kåre I. Birkeland
Journal: Endocrine Reviews (2009)

Infusion of insulin acutely stimulates leptin production and chronic insulin treatment is associated with elevated serum leptin levels and body weight in patients with type 2 diabetes. The objective of the study was to investigate the relationship between insulin administration, leptin levels, and weight gain in patients with type 2 diabetes. This was a post hoc analysis of two randomized, controlled trials. The study was conducted at an outpatient clinic. Patients included 35 (study 1) and 32 (study 2) poorly controlled oral hypoglycemic agent (OHA)-treated type 2 diabetic patients. Study 1: patients were investigated during a hyperinsulinemic, euglycemic glucose clamp and 12 months after being randomly allocated to start insulin or continue on OHAs. Study 2: 1 yr treatment with either OHAs and lifestyle intervention or insulin with or without concomitant lifestyle intervention. Changes in serum leptin levels during clamp and during 1 yr of treatment in relationship to changes in body weight. Study 1: during acute insulin infusion leptin levels increased by 10% (P < 0.001). During 1 yr of insulin therapy, mean body weight increased by 6%, whereas the fasting leptin levels increased by 108% (both P < 0.001). The weight gain observed at 1 yr correlated with the increase in leptin levels observed during the clamp (r = 0.62, P = 0.003). Study 2: mean body weight increased by 4% (P < 0.01), whereas leptin levels increased by 56% (P < 0.001) during 1 yr of insulin treatment and the increase in leptin preceded the increase in body weight. Significant correlations were observed between insulin’s effect on soluble leptin levels and the increase in weight that accompanied insulin therapy.
Bleomycin-Induced Lung Injury in the Rat: Effects of the Platelet-Activating Factor (PAF) Receptor Antagonist BN 52021 and Platelet Depletion
Authors: Timothy W. Evans, Robin J. McAnulty, Duncan F. Rogers, K. Fan Chung, Peter J. Barnes, Geoffrey J. Laurent
Journal: Environmental Health Perspectives (1990)

Bleomycin is a highly effective antitumor agent, but pulmonary toxicity, characterized by an acute inflammatory reaction and associated pulmonary edema, limits clinical use of the drug.Platelets and platelet-activating factor (PAF), a membrane-derived phospholipid, have been implicated in the mechanisms that can mediate pulmonary microvascular injury.We sought to investigate the role ofPAF in bleomycin-induced lung injury in the rat, using the PAF receptor antagonist BN 52021; and the role of platelets though the use of an anti-platelet antibody.Lung injury was induced by intratracheal bleomycin (1. 5 mg) and assessed by measurements oflung wet weight and total pulmonary extravascular albumin space (TPEAS).Bleomycin caused a significant increase in both indices after 48 hr, compared with control animals (p < 0.05).A single dose of BN 52021 (20 mg/kg orally) significantly reduced the bleomycin-induced increase in lung weight, but not the rise in TPEAS (p > 0.05).Increasing the dose of BN 52021 (20 mg/kg/12 hr, orally) had no additional effect.Reducing circulating platelet numbers by approximately 75 % had no effect on either the increase in lung weight or TPEAS, observed 48 hr after bleomycin (p > 0.05).PAF may partially contribute to the acute infiamtory reaction seen after intratracheal bleomycin in rats.
Errata
Authors: Paul Fowler, Peter O'shaughnessy, Stewart Rhind, Jon Ayres, Hyunok Choi, John Spengler, Frederica Perera, Thomas Burke, Francesca Dominici, Mary Fox, Ronald White, Ila Cote, Dale Hattis, Jonathan Samet, Paul White, Lauren Zeise
Journal: Environmental Health Perspectives (2009)