tbuckley/cabot-search huggingface dataset:
PARKINSON'S DISEASE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vitamin A deficiency potentiates carbon tetrachloride-induced liver fibrosis in rats
Authors: W Seifert
Journal: Hepatology (1994)

Earlier studies have shown that retinoid administration suppresses the generation of hepatic fibrosis and stimulates its regression in normal (i.e., vitamin A-sufficient) carbon tetrachloride-treated rats. This study focuses on the possible role of a marginal or deficient vitamin A status on carbon tetrachloride-induced fibrosis. This experimental study in rats shows that vitamin A status, reflected by hepatic retinoid content (retinol and retinyl esters), modulates the development of hepatic fibrosis induced by carbon tetrachloride. In rats with low hepatic retinoid levels (12 ± 0.9 μg/gm liver), carbon tetrachloride-induced liver fibrosis was more pronounced than in rats with sufficient hepatic retinoid levels (1,065 ± 327 μg/gm liver). Enhanced liver fibrogenesis was confirmed both morphologically and by a higher hydroxyproline content of the liver. It was associated with a reduced liver weight and the development of parenchymal regeneration nodules. Furthermore, carbon tetrachloride treatment itself reduced the hepatic retinoid content in rats independently of the liver vitamin A status before treatment and increased serum retinol levels in vitamin A-sufficient rats. The results show that the vitamin A status of the liver plays an important role in hepatic fibrogenesis. Low hepatic vitamin A levels, which can be the result not only of low dietary intake but also of interference with vitamin A metabolism by agents such as ethanol and carbon tetrachloride, may be a risk factor for the development of liver fibrosis. We suggest that retinoids modulate collagen synthesis and deposition irrespective of the degree of hepatocellular necrosis induced by carbon tetrachloride. The reduction of retinoid levels in fat-storing cells and fibroblast-like cells by an enhanced secretion of retinol from the liver into the circulation during carbon tetrachloride treatment may stimulate the transformation of these cells to fibroblasts and, in this way, contribute to fibrogenesis of the liver. (Hepatology 1994;19:193–201).
Neuropsychiatry
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Authors: Sergio Anastasi
Journal: Hepatology (2019)

1Unit of Oncogenomics and EpigeneticsRegina Elena National Cancer InstituteRomeItaly *Address Correspondence and Reprint Request to: Sergio Anastasi, Ph.D. Unit of Oncogenomics and Epigenetics Regina Elena National Cancer Institute via E. Chianesi, 53 00144 Rome, Italy Email: [email protected] Tel.: +39‐0652662568
Detoxification of sick addicts in prison
Authors: V. P. Dole
Journal: JAMA (1972)

More than 22,000 heroin addicts have been successfully detoxified during the past nine months in the detention jails of New York City. By standardizing the dosage schedules and the dispensing routines, it has been possible to conduct this large program within the cell blocks of the institutions. Violence and suicides, which occurred frequently before the treatment was started, have been completely absent in the detoxification areas. The treatment program now is a starting point for placement of addicts in community-based narcotics treatment programs.
Corrigendum
Journal: BMJ (1945)

ANSWERS BRITISCOand it is possible that lacrimation might occur under the same cir- cumstances.The phenomenon of " crocodile tears," in which the normal flow of saliva at meal times is.accompanied by lacrimation, is due to injury to the chorda tympani branch of the seventh cranial nerve.Bilateral salivation and lacrirnation in an elderly man would suggest either paralysis agitans or vascular degenerative changes in the cortical vessels.Presuming one of these two conditions was responsible, treatment should be by atropine or stramonium, pushed, if necessary, to the limit of tolerance as shown by disturbance of ocular accommodation.Novocain Injections Q.-It is very easy to pierce a vein with the fine needle used by denitists.The anaesthetic solutiont usually contains 3% novocain and a variable amzount of adrenaline (aboult 0.00002 gr. per c.cm. or miiore).What are the dangers of direct inijection into the blood steanm ?How much is due to novocain atnd how much to the adrenaline content?A.-The dangers of direct injection of the anaesthetic solution into the vascular system are not great.It is unlikely that enough will enter the blood stream to produce noteworthy toxic effects unless the patient has a marked idiosyncrasy to one or other of the drugs.Intravenous administration of adrenaline is a dangerous procedure,
THE POSSIBILITIES FROM FELLOWSHIP IN THE COUNTY SOCIETY.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperparathyroidism with a prolonged period of normocalcemia
Authors: R. D. Johnson
Journal: JAMA (1969)

Hyperparathyroidism was proved in a patient who had intermittent hypercalcemia, with one period of normocalcemia which lasted for 12 months. We are in general agreement with others that parathyroid exploration should not be carried out in patients with normocalcemia, but the demonstration of a single or occasional elevation of serum calcium level may be very significant and should commit the physician to careful and prolonged observation of such patients. Evidence suggests that the blood level of parathyroid hormone was elevated even when the serum calcium concentration was normal.
Alcohol-Attributable Deaths and Years of Potential Life Lost—United States, 2001
Journal: JAMA (2004)

Excessive alcohol consumption is the third leading preventable cause of death in the United States and is associated with multiple adverse health consequences, including liver cirrhosis, various cancers, unintentional injuries, and violence. To analyze alcohol-related health impacts, CDC estimated the number of alcohol-attributable deaths (AADs) and years of potential life lost (YPLLs) in the United States during 2001. This report summarizes the results of that analysis, which indicated that approximately 75,766 AADs and 2.3 million YPLLs, or approximately 30 years of life lost on average per AAD, were attributable to excessive alcohol use in 2001. These results emphasize the importance of adopting effective strategies to reduce excessive drinking, including increasing alcohol excise taxes and screening for alcohol misuse in clinical settings.
Fasting-Induced Hepatic Production of DHEA is Regulated by PGC-1α, ERRα and HNF4α
Authors: Linda L. Grasfeder, Stephanie Gaillard, Stephen R. Hammes, Olga Ilkayeva, Christopher B. Newgard, Richard B. Hochberg, Mary A. Dwyer, Ching-yi Chang, Donald P. McDonnell
Journal: Endocrine Reviews (2009)

ABSTRACT The transcriptional coactivator PGC-1α is involved in the coordinate induction of changes in gene expression in the liver that enable a homeostatic response to alterations in metabolic state, environmental cues and nutrient availability. In exploring the specific pathways under PGC-1α regulation in the liver, we have made the surprising observation that this coactivator can induce the expression of CYP11A1 and CYP17A1, key rate limiting enzymes involved in the initial steps of steroidogenesis. Both of these enzymes function to produce C19-steroids, converting cholesterol into pregnenolone, and then to DHEA. ERRa mediates PGC-1α’s induction of CYP11A1 and binds within the first intron of the CYP11A1 gene. Both ERRa and HNF4a are required for PGC-1α-mediated induction of CYP17A1 and specific binding sites for these receptors have been identified in the regulatory regions of this gene. The potential physiological significance of these observations was highlighted in rats where fasting induced hepatic expression of PGC-1α and CYP17A1 and was associated with an increase in hepatic levels of DHEA. These data suggest that DHEA could be playing a role as an intracellular signaling molecule involved in modulating hepatic activity in response to fasting conditions.
Transactions of the Medical Society of New Jersey, 1896.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biochemistry, Washington
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene Transfer of the Serine Elastase Inhibitor Elafin Protects Against Vein Graft Degeneration
Authors: Stacy B. O’Blenes, Syed H. E. Zaidi, Alexander Y. L. Cheah, Brendan McIntyre, Yasufumi Kaneda, Marlene Rabinovitch
Journal: Circulation (2000)

Background —Leukocyte infiltration and serine elastase activity lead to smooth muscle cell proliferation in association with posttransplant coronary arteriopathy and may also be involved in vein graft neointimal formation. A number of therapies have targeted cellular proliferation, but the inhibition of serine elastase–mediated extracellular matrix remodeling has not been investigated as a potential strategy to prevent neointimal formation and subsequent atherosclerotic degeneration in vein grafts. Methods and Results —We studied jugular vein grafts 48 hours after interposition into the carotid arteries of rabbits and demonstrated inflammatory cell infiltration and elevated serine elastase activity, a stimulus for matrix remodeling and deposition of elastin. Therefore, elastolytic activity in vein grafts was targeted through transient expression of the selective serine elastase inhibitor elafin with hemagglutinating virus of Japan liposome–mediated gene transfer. Elafin transfection reduced inflammation by 60% at 48 hours and neointimal formation by ≈50% at 4 weeks after implantation. At 3 months, a 74% decrease in neointimal elastin deposition correlated with protection against cholesterol-induced macrophage infiltration and lipid accumulation, which were both reduced by ≈50% in elafin-transfected grafts relative to controls. Conclusions —Gene transfer of the selective serine elastase inhibitor elafin in vein grafts is effective in reducing the early inflammatory response. Although transient expression of elafin delays neointimal formation, it is also sufficient to cause an alteration in elastin content of the extracellular matrix, making it relatively resistant to atherosclerotic degeneration.
The assessment and treatment of geezers
Authors: L. Pankratz
Journal: JAMA (1988)

<i>WEBSTER'S</i>defines a geezer as an odd or eccentric man. We write about geezers because they have predictable and understandable problems when forced into the health care system. We hope to promote an appreciation for their rich life histories and idiosyncratic charm. Survivors of the dust bowl and the Great Depression endured hardships unimaginable to the young physician. The geezer is the rural or working-class man who emerged from these adverse circumstances with a fierce independence blazed from solving problems with his own hands. Like an old oak, he is strong and rigid but brittle. He may collapse suddenly when the storms of serious illness overwhelm his self-sufficiency. The geezer has limited formal education, and he is unimpressed by diplomas and certificates. He has his own idea of competence, dismissing house staff with uncanny accuracy as "whippersnappers." After cogitating our advice, he does what he damned well pleases. He is
A Practical Medical Dictionary of Words Used in Medicine with Their Derivation and Pronunciation, Including Dental, Veterinary, Chemical, Botanical, Electrical, Life Insurance and Other Special Terms; Anatomical Tables of the Titles in General Use, and Those Sanctioned by the Basle Anatomical Convention; Pharmaceutical Preparations, Official in the U. S. and British Pharmacopeias and Contained in the National Formulary; Chemical and Therapeutic Information as to Mineral Springs of America and …
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Miscellany.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver Scanning
Authors: Alexander Gottschalk
Journal: JAMA (1967)

Because the liver has numerous and varied functions, finding tracers that will accumulate in it is relatively easy. As a consequence, liver scanning is widespread, and will usually account for a significant percentage of all scanning procedures done in a busy laboratory of nuclear medicine. Careful consideration of hepatic structure and physiology, coupled with the current status of nuclear instrumentation, however, leads to the conclusion that the liver is in many ways the most difficult organ to scan well. This apparent paradox is partially explained by the lack of a routine radiographic examination that gives adequate information about the liver. It is the purpose of this communication to discuss the strengths and weaknesses of liver scanning so that the maximum benefit from this procedure can be obtained for the patient. Liver scanning provides a simple means of assessing hepatic configuration, size, and intro-abdominal location. The study is also commonly used
(17) Spasticity and vascular lesions
Authors: B.R. Allen
Journal: British Journal of Dermatology (1978)

Journal Article (17) Spasticity and vascular lesions Get access B.R. Allen B.R. Allen General Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 98, Issue s16, 1 July 1978, Pages 42–43, https://doi.org/10.1111/j.1365-2133.1978.tb13619.x Published: 01 July 1978
Book Review Obstetrics: Normal and Problem Pregnancies Second edition. Edited by Steven G. Gabbe, Jennifer R. Niebyl, and Joe Leigh Simpson. 1409 pp., illustrated. New York, Churchill Livingstone, 1991. $84.95. ISBN 0–443–08714–8 . Scientific Foundations of Obstetrics and Gynaecology Fourth edition. Edited by Elliott Philipp and Marcus Setchell, with Jean Ginsburg. 764 pp., illustrated. Boston, Butterworth-Heinemann, 1991. $275. ISBN 0–7506–0184–1 . Illustrated Textbook of Obstetrics Second …
Authors: John S. Weitzner
Journal: New England Journal of Medicine (1992)
From the Centers for Disease Control. Public Health Service report on fluoride benefits and risks
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal