tbuckley/cabot-search huggingface dataset:
Aerztliche Forschung, Munich
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Munchausen's may occur in younger persons
Authors: C. A. Raymond
Journal: JAMA (1987)

FIRST DESCRIBED 36 years ago (<i>Lancet</i>1951;1:339-341), Munchausen's syndrome has been considered a rare psychiatric aberration occurring predominantly in adult men in their late 30s. However, evidence presented at the Society for Adolescent Medicine meeting in Seattle suggests that, in fact, the syndrome may be much more common, occur at a much earlier age, and have its origin in childhood abuse or neglect. Ed Tyson, MD, and Dennis Fortenberry, MD, of the University of Oklahoma Health Sciences Center, Oklahoma City, were introduced to Munchausen's syndrome in the way that many other clinicians have been: by encountering a patient with a long history of hospital admissions for numerous unrelated disorders. In this case, the patient was a 19-year-old woman who, over a three-year period, had seen 31 physicians in 12 specialties, been hospitalized 15 times for 154 days, and undergone 38 radiological procedures and 182 laboratory tests for a variety of
Reproductive toxicology. Diethylstilbestrol.
Authors: James Lamb, Jerry Reel, Rochelle Tyl, A Lawton
Journal: Environmental Health Perspectives (1997)

CHHs HO ~C=C-'s" OH -~~~~~~~~~~~~~~~~~~~~I C2H5 Diethylstilbestrol (DES), the least expen- sive and most widely used estrogen, was tested in Swiss CD-1 mice using the RACB protocol (Lamb et al., J Am Coll Toxicol 4(2): 173-184 [1985]).This study was one of the first RACB studies conducted.DES was chosen as a known posi- tive based on the extensive literature by MacLachlan and colleagues.There were two laboratories beginning to run RACB studies, and a DES study was performed at each of these laboratories to address the issue of interlaboratory variability.From the dose-range-finding study (Task 1), levels of 1.0, 10.0 and 50.0 ppb in feed were selected for the continuous breeding phase of the study.The estimated average
Human and mouse gastrointestinal tumour distribution is selected according to a basal intestinal wnt signalling gradient
Authors: P. Rodenas-Cuadrado, K. Howarth, A. Lewis, S. Mallappa, R. Jeffry, M. Rodriguez-Justo, J. East, S. Travis, S. Clark, I. Tomlinson, S. Leedham
Journal: Gut (2011)

<h3>Introduction</h3> It is established that <i>Adenomatous polyposis coli (APC)</i> mutations occur non-randomly with respect to each other, resulting in characteristic genotype-phenotype correlations in colorectal cancer (CRC). We have recently compared two mouse polyposis models (<i>Apc</i><sup><i>Min</i></sup> and <i>Apc</i><sup><i>1322T</i></sup> mice) to demonstrate that ‘just-right’ levels of wnt signalling underpin the severity and distribution of lesions in mouse intestinal neoplasia. We have also shown that human <i>APC</i> mutation spectra varies according to the anatomical distribution of colorectal lesions. We hypothesise that an intestinal gradient of wnt signalling and stem cell number may influence optimal mutation spectra selection. <h3>Methods</h3> Wnt target gene activity in individual small intestinal and colonic whole mount crypts was assessed using qRT-PCR. Stem cell number was counted using in-situ hybridization for <i>Lgr5</i>. The regional intestinal effect of increased wnt signalling was examined in the mouse using a stabilized beta catenin transgenic model (<i>Villin-CreERT2; Catnb</i><sup><i>lox(ex3)/lox(ex3)</i></sup>) and the human by comparing upper gastrointestinal (UGI) and colonic <i>APC</i> mutation spectra in FAP and sporadic CRC patients. <h3>Results</h3> Wnt target gene activity and stem cell number were greatest in the proximal small intestine (SI) decreasing steadily through to the colon. The <i>BMP2</i> gradient was inversely correlated. The stabilized beta catenin transgenic mice had a striking phenotype with lesion distribution mirroring this gradient. Human FAP associated UGI <i>APC</i> mutations retained more beta-catenin binding 20 amino-acid repeats (AAR) than the same patient9s colonic lesions. Sporadic CRC lesion distribution tended to vary according to the number of 20AAR9s retained with left sided lesions requiring fewer 20AAR9s than right sided. <h3>Conclusion</h3> The ‘just right’ hypothesis proposes a threshold of wnt signalling should be reached but not exceeded in order for polyp formation to occur. We have demonstrated a physiological SI to colonic gradient of wnt signal and stem cell number. Thus the wnt signal threshold gap varies throughout the intestinal tract. Beta-catenin stabilization in the mouse provides sufficient wnt signal perturbation to initiate tumour formation in the small intestine but is insufficient in the colon. The physiological wnt gradient determines the distribution of sporadic and polyposis-associated tumours by selecting for the optimal mutation spectra in each lesion – thus left sided lesions select for common mutations that provide a greater wnt perturbation than their more proximal counterparts.
Hazards of prolonged intubation and trarcheotomy equipment
Authors: L. Rendell-Baker
Journal: JAMA (1968)

After open-heart and other major surgery, prolonged endotracheal intubation for postoperative respiratory assistance may cause irritation and damage to the mucous membranes of the airways. The communication by Guess and Stetson on page 580 of this issue draws attention to one possible cause, if polyvinyl chloride (PVC) plastic tubes are used. Though unnoticed in medical journals, this problem has concerned scientists for some years. It is appropriate, therefore, to alert the medical profession to several difficulties which have arisen with this equipment. All PVC used for endotracheal tubes contains stabilizer compounds which, during use, tend to leach out of the plastic. Guess and Stetson show that some stabilizers may cause serious irritation when the plastic remains in contact with the tissues for several days. When tubes were used solely for anesthesia, past freedom from complaints may be explained by the shorter period of contact. In the absence of national standards
The Child Health Library.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NEW VIEW OF DERMOGRAPHISM
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurological Involvement in Acute Falciparum Malaria in Kenyan Children—Reply
Authors: Richard Idro, Jane Crawley, Kevin Marsh, Charles R. J. C. Newton, Brian G. R. Neville
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insomnia and Drug Addiction.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RHEUMATISM, AND ITS TREATMENT BY TURKISH BATHS
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatrics
Authors: L. Finberg
Journal: JAMA (1990)

Developments in the field of pediatrics over the past year or two have centered on a changing major subfield, neonatology, where events have either surprised or overtaken us, and on genetics, which is foreshadowing the future of pediatric care. Two controversial issues have also emerged: to test or not to test universally for cholesterol levels in children and how to react to the advertising of infant formula to the public. The argument for universal testing of children for cholesterol levels includes the following considerations<sup>1</sup>: (1) Atherosclerosis is the basis for more deaths in later life than any other cause. (2) Testing adult cholesterol levels leads to interventions that reduce coronary artery disease; therefore, it may have a similar beneficial effect in children. (3) Atherosclerosis begins in late childhood; therefore, early dietary intervention will be useful. (4) Testing only children from "high-risk" families misses many (some say as much as
Membership of Committees on Education
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smoking-Related Mortality Decline Among Physicians—Rhode Island
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EPT-14PHASE I STUDY OF GENE MEDIATED CYTOTOXIC IMMUNOTHERAPY WITH AdV-tk AS ADJUVANT TO SURGERY AND RADIATION THERAPY FOR PEDIATRIC MALIGNANT GLIOMA AND RECURRENT EPENDYMOMA
Authors: Mark W. Kieran, Liliana Goumnerova, Peter Manley, Susan N. Chi, Karen Marcus, Andrea G. Manzanera, Estuardo Aguilar-Cordova, Arthur J. DiPatri, Tadanori Tomita, Rishi Lulla, Laura K. Aguilar, Stewart Goldman
Journal: Neuro-Oncology (2016)
Genes and Alzheimer Disease
Journal: Annals of Internal Medicine (2002)

Summaries for Patients6 August 2002Genes and Alzheimer DiseaseSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-3-200208060-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?There are thousands of genes in a human body cell. The genes occur on 23 pairs of chromosomes. Each gene on a chromosome has a counterpart on the matching chromosome. Genes in a matching pair may be identical or different. Different forms of the same gene are known as alleles. A single gene may have a few or several hundred different alleles. Alleles account for the inherited differences among people, such as varying eye and hair color. Alleles may also play a part in the cause and progression ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Apolipoprotein E ε4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease.” It is in the 6 August 2002 issue of Annals of Internal Medicine (volume 137, pages 149-155). The authors are M Kivipelto, E-L Helkala, MP Laakso, T Hänninen, M Hallikainen, K Alhainen, S Iivonen, A Mannermaa, J Tuomilehto, A Nissinen, and H Soininen.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoApolipoprotein E ε4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease Miia Kivipelto , Eeva-Liisa Helkala , Mikko P. Laakso , Tuomo Hänninen , Merja Hallikainen , Kari Alhainen , Susan Iivonen , Arto Mannermaa , Jaakko Tuomilehto , Aulikki Nissinen , and Hilkka Soininen Metrics 6 August 2002Volume 137, Issue 3Page: I-18KeywordsAllelesAlzheimer diseaseApolipoproteinsBlood pressureCholesterolChromosomesDementiaHypercholesterolemiaPrimary hypertensionSystolic pressure ePublished: 6 August 2002 Issue Published: 6 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Rucksack Paralysis
Authors: Diana Reynard
Journal: JAMA (1969)

<h3>To the Editor:—</h3> As a hiking and backpacking enthusiast, I was most interested in the paper "Rucksack Paralysis" by J. R. Daube, MD (<b>208</b>:2447, 1969). It seems to me that this syndrome of brachial plexus injury is not entirely the result of improper design and/or overloading of the Army pack. The men may have had "rucksack paralysis" as the result of neglecting to fasten the hip belt, as the paper indicates; a serious mistake that veteran backpackers warn novices to avoid. The hip belt is not a "safety strap." Properly adjusted (it should be snug but not too tight), it displaces nearly all of the load to the hips where it belongs, relegating the shoulder straps to their proper secondary function of keeping the pack in position. When this belt is fastened, the wearer finds that his shoulders are suddenly released from nearly all their load; in fact, the
LABORATORY SAFETY
Authors: C.E.D. Taylor, E.W. Williams, S.W.B. Newsom, A.M. Rampling, J.M. Boissard, V.A. Mcneice, J. Nagington, J.R. Walker, R.E. Warren, T.G. Wreghitt, D.F.J. Brown, H.W.K. Fell, J.V.T. Gostling, R.W. Lacey, R. Pilsworth, J.A. Rycroft, B.E. Andrews, W. Shepherd, C.G.A. Thomas, A.L. Yaneza
Journal: The Lancet (1980)
Doctors and Patients
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal