tbuckley/cabot-search huggingface dataset:
Cyanide Poisonings Associated With Over-the-Counter Medication—Washington State, 1991
Journal: JAMA (1991)

On February 2, 9, and 17, 1991, three persons in western Washington state, who had taken SUDAFED 12-Hour capsules (manufactured by Burroughs Wellcome Company) for nasal congestion, had onset of acute cyanide poisoning; two died. This report updates an ongoing investigation by the Food and Drug Administration (FDA) and other agencies.
Electrocardiographic Notebook
Authors: Alvan R. Feinstein
Journal: JAMA (1964)

This little book may do to the electrocardiographic publishing industry what well-designed small foreign cars did to the dinosaurs of Detroit. The large ones will still be sought for their details and ornate elaboration, but smaller versions of the mammoths have been demanded and improved for people who want useful, practical conveyances. The book is so small and flexible (paper-covered) that it can fit comfortably into a coat pocket, yet its contents are enormously rich and full. Within its compact pages the author has managed to cover the main points of electrocardiography. Anatomic and significant psychological considerations are noted, tables of normal values listed, special leads mentioned, and an excellent, adequately comprehensive selection of abnormal states described and illustrated. The approach is no-nonsense, logical, crisp, clear, clinical, and pragmatic—and the writing contains prose to match the approach. Not a sentence, hardly a word is wasted, yet the style is always
Conditional survival of patients with metastatic testicular germ-cell carcinoma (MT-GCT) treated with first-line curative therapy.
Authors: Jenny J. Ko, Tehmina Asif, Haocheng Li, Nimira S. Alimohamed, Thao Phuong Nguyen, Daniel Yick Chin Heng
Journal: Journal of Clinical Oncology (2015)

e20639 Background: The IGCCCG risk stratification accurately predicts survival outcomes in MT-GCT at baseline, but how the initial risk changes over time for those who survived since curative treatment (conditional survival) is unknown. Methods: We included consecutive patients who received 1st-line chemotherapy for MT-GCT at two tertiary cancer centres in Canada from January 1990 to December 2013.We assessed 2-year (Y) conditional overall survival (COS), defined as the probability of surviving an additional 2Y, and 2Y conditional disease-free survival (CDFS), defined as the probability of surviving and disease-free for an additional 2Y, at a given timepoint since the start of first-line treatment. Outcomes were stratified by IGCCCG risk criteria and compared between seminoma and non-seminoma. Results: Median follow-up for all patients (n = 323) was 41 months (m) (IQR 24-52). There was an increase in 2Y COS from 92% (95% CI 89–95) at 0m to 98% (95–99) at 24m, and in 2Y CDFS from 82% (77-86) at 0m to 96% (93-98) at 24m since first-line curative therapy. 2Y COS changed little in the IGCCCG favourable and intermediate groups, but in the poor-risk group, improved from 76% (62–87) at 0m to 94% (81–99) after 24m. 2Y CDFS for favourable risk group improved significantly from baseline to 24m (89 vs. 96%); intermediate, from baseline to 18m (82 vs. 100%); poor, from baseline to 12m (53 vs. 86%). The IGCCCG prognostic risk stratification predicted 2Y OS and DFS for each risk group at first-line therapy initiation (p = 0.01), but could no longer predict COS (p = 0.19 at 18m) or CDFS (p = 0.12 at 12m) with statistical significance lost once a patient survived to 1Y post therapy. No significant differences in COS and CDFS were noted between seminoma and non-seminoma (p = 0.91 and 0.52, respectively). Conclusions: Our data suggest that the concept of conditional survival applies to patients with MT-GCT treated with curative therapy and may be useful in patient counseling during follow-up. A poor-risk patient, after 1 year of survival, had the same probability of relapse and survival as a favourable/intermediate risk patient. There were no differences in conditional survival between seminoma and non-seminoma.
BRAZIL
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ON THE COVER
Authors: Jane Van Dis
Journal: JAMA (2003)

AROUND THE SAGEgreen door, save for light sifting through the metal blinds and the bluegray glow of the screen as it showed off its sandy sonographic images of the abdominal wall, placenta, and fetus.The obstetrician moved the slickened transducer across the woman's abdomen, pointing out landmarks and serving as guide to this anatomical museum suspended in amnion."This is baby's kidney.And over here we have baby's stomach."Baby?Talking in the hallway out of the patient's earshot, my attending remarked, "The fetus appears on exam to be healthy."Although the proper use of "baby" vs "fetus" is generally not a part of formal obstetric training for medical students, maternal-fetal ethics instruction is a component of medical and resident education.A 1994 study found that the top 2 issues of interest in obstetric ethics education were "abortion" and "maternal-fetal conflict." 1 Although obstetricians rarely encounter ethical dilemmas like courtordered cesarean deliveries or pregnant patients refusing lifesustaining blood transfusions, unplanned pregnancy and drug and alcohol use during pregnancy are common occurrences. 2,3Thus it is not surprising that the pregnant woman is a focus of complex cultural expectations, moral obligations, and legal rights.This issue of MSJAMA addresses some of the constructs and tensions in the maternal-fetal relationship.The maternal-fetal relationship is the subject of intense public policy debates.Lisa Harris and Lynn Paltrow report on courts' opinions regarding the prosecution of pregnant women for potential fetal harm.Nathan Stormer explores how contemporary biomedical images of the fetus are changing public perception of the pregnant body and fetus.Amy Salisbury and colleagues describe how researchers are attempting to measure maternal-fetal attachment and its possible implications for fetal and maternal health during pregnancy.Although fundamental and seemingly unalterable, the definition of the maternal-fetal relationship is undergoing a rapid evolution of context, in part due to advances in imaging, prenatal diagnostics, genetic screening, and fetal surgery.While the formal principles of autonomy and beneficence provide an initial point from which to analyze the sometimes conflicting needs of the pregnant woman and her fetus, the maternal-fetal relationship is becoming too complex to rely on simple algorithms.As medical technology and innovation advance, and as cultural and political dialogues continue to influence the patient-physician encounter, physicians' knowledge of and participation in ethical dialogue on the maternal-fetal relationship will continue to be an increasingly important part of obstetric care.
Startle reaction to air-bag restraints
Authors: H. H. Ziperman
Journal: JAMA (1975)

Air bags in vehicles constitute a means of passive restraint for individuals involved in auto accidents. There is fear, however, that the inadvertent nonaccident-connected deployment of one of these air bags might substantially interfere with the handling of a vehicle in which such deployment occurred. We have found that while physiologic and physical evidence of startle accompanies such unexpected deployment, good control of the vehicle continues to be exercised by the test subjects under the conditions of our experimental protocol. (<i>JAMA</i>233:436-440, 1975)
PAN-AMERICAN EXCURSION.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3457: Methylenetetrahydrofolate Reductase Gene Polymorphism C677T And The Risk Of Premature Myocardial Infarction With “Normal” Coronary Arteries.
Authors: Loukianos Rallidis, Christoforos Komborozos, Argyri Gialeraki, Maria Zolindaki, Panagiotis Vavoulis, Kostas Papadopoulos, Anthi Travlou, Dimitrios Kremastinos
Journal: Circulation (2007)

Purpose: the pathogenetic mechanism of acute myocardial infarction (AMI) in young patients remains unknown. We explored the impact of homocysteine and its main genetic modulator Table 2 methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in patients who sustained AMI under the age of 36 years. Methods: we recruited 136 consecutive patients who had survived their first AMI before the age of 36 years (mean age=32 ± 3.1 years, range 23–35 years, 121 men). Blood was taken for lipids and homocysteine levels within 12 hours from admission. The MTHFR C677T polymorphism was also determined with polymerase chain reaction. All patients underwent cardiac catheterization. One hundred-three healthy individuals without a family history of coronary heart disease (CHD), matched for age and sex served as controls. Results: coronary angiogram revealed significant CHD in 104 patients while 32 (23.5%) had no significant CHD. The prevalence of homozygotes for C677T polymorphism [T/T genotype] was 27.2% in patients and 14.6% in controls (p=0.02). In the subgroup of patients who had AMI and “normal” coronary arteries the frequency of homozygotes was 43.8% (p=0.001 versus controls and p=0.02 versus patients with significant CHD). The table presents lipids and homocysteine levels in AMI patients with “normal” coronary arteries and controls. Logistic regression model showed that the odds ratio for a young individual with T/T genotype to develop AMI with “normal” coronary arteries was 5.2 (confidence interval 1.2–23, p=0.03) adjusted for smoking habits, body mass index, hypertension and diabetes mellitus. Conclusions: the presence of homozygocity for MTHFR C677T polymorphism is associated with 5-fold higher risk for premature AMI with “normal” coronary arteries. This suggests that homocysteine may be involved in the formation of an obstructive thrombus in coronary arteries, especially in young individuals without significant underlying atheromatic burden.
THE PHYSICIAN'S RETURN FOR THE INSANE, FEEBLE-MINDED, DEAF, BLIND AND SICK, FOR THE ELEVENTH CENSUS OF THE UNITED STATES.
Journal: JAMA (1890)

The circular issued on the 15th of May, from the Census Office under the authority of the Department of the Interior and over the signature of "John S. Billings, Surgeon U. S. A, In Charge of Vital Statistics and Statistics of Special Classes," has been the subject of considerable comment by the public press, the consensus of opinion among the physicians interviewed all over the country being represented as adverse to the proposed method of obtaining statistics of the physically and mentally afflicted classes of the community. Medical journals have generally abstained from more than casual reference to the matter, since while they are all agreed in believing the information sought to be of the most vital importance to the health statistics of the country, the manner of obtaining it contemplated by the circular, is undoubtedly open to serious objection. The circular states, that " each census enumerator, in making a
Medicina Experimentalis, Basel
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuing Medical Education
Authors: Dennis K. Wentz
Journal: JAMA (1989)

A number of activities that may eventually change the field of continuing medical education (CME) occurred this past year. This report will summarize many of these initiatives, as well as update ongoing CME activities occurring between May 1, 1988, and May 1, 1989. <h3>COOPERATION IN CME</h3> Following the landmark First National Congress on Continuing Medical Education held in Los Angeles, Calif, in April 1988, several of the sponsoring organizations indicated a desire to meet informally on an ongoing basis to explore areas for CME cooperation and collaboration. Thus, on October 8, 1988, the American Medical Association (AMA) hosted a meeting in Chicago, Ill, entitled "Coordination in Continuing Medical Education." The invitees were representatives from the Alliance for Continuing Medical Education (ACME), Accreditation Council for Continuing Medical Education (ACCME), Association of American Medical Colleges, Association for Hospital Medical Education, AMA, Council on Medical Specialty Societies, Society for Medical College Directors of Continuing
Microtubules
Authors: Nancy L.R. Bucher
Journal: New England Journal of Medicine (1972)

The drug colchicine, a gift from the ancients to students of cell division and to gout sufferers, has lately acquired new distinction. When cells divide, they develop a special apparatus for distributing the chromosome complements equally to the two daughters. The framework of this apparatus is the mitotic spindle, whose fibers are composed of microtubules. Microtubules, generally identical in appearance to spindle fibers, are also observable in most if not all nondividing cells. Colchicine has a special affinity for microtubules and has provided new insight into their distribution, structure and functions.Microtubules are the most prominent of several types of . . .
Presidential Address
Authors: CHESTER M. JONES
Journal: Annals of Internal Medicine (1962)

Special Article1 July 1962Presidential AddressCHESTER M. JONES, M.D., M.A.C.P.CHESTER M. JONES, M.D., M.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-1-164 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs President of the American College of Physicians, it is now my duty and privilege to welcome and address you, the members and guests of the College, here present at its forty-third annual session. I propose to discuss the College in terms of its aims, its performance, its opportunities and obligations, and its growth. I have been honored by the College by having been elected a vice-president in 1956, and have since had the privilege of serving as a regent, as President-Elect, and now as President, since that date. This rich experience has provided me with an extraordinary opportunity to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsDelivered before the forty-third annual session of The American College of Physicians, Philadelphia, Pennsylvania, April 9, 1962.Requests for reprints should be addressed to Chester M. Jones, M.D., 275 Charles Street, Boston 14, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1962Volume 57, Issue 1Page: 164-168 Issue Published: 1 July 1962 PDF DownloadLoading ...
Sustained Effect of Intensive Treatment of Type 1 Diabetes Mellitus on Development and Progression of Diabetic Nephropathy
Journal: JAMA (2003)

ContextThe Diabetes Control and Complications Trial (DCCT) demonstrated the benefits of intensive treatment of diabetes in reducing glycemic levels and slowing the progression of diabetic nephropathy. The DCCT cohort has been examined annually for another 8 years as part of the follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study. During the EDIC study, glycemic levels no longer differed substantially between the 2 original treatment groups.ObjectiveTo determine the long-term effects of intensive vs conventional diabetes treatment during the DCCT on kidney function during the EDIC study.Design, Setting, and ParticipantsObservational study begun in 1993 (following DCCT closeout) in 28 medical centers in the United States and Canada. Participants were 1349 (of 1375) EDIC volunteers who had kidney evaluation at years 7 or 8.Main Outcome MeasuresDevelopment of microalbuminuria, clinical-grade albuminuria, hypertension, or increase in serum creatinine level.ResultsResults were analyzed by intention-to-treat analyses, comparing the 2 original DCCT treatment groups. New cases of microalbuminuria occurred during the EDIC study in 39 (6.8%) of the participants originally assigned to the intensive-treatment group vs 87 (15.8%) of those assigned to the conventional-treatment group, for a 59% (95% confidence interval [CI], 39%-73%) reduction in odds, adjusted for baseline values, compared with a 59% (95% CI, 36%-74%) reduction at the end of the DCCT (P&lt;.001 for both comparisons). New cases of clinical albuminuria occurred in 9 (1.4%) of the participants in the original intensive-treatment group vs 59 (9.4%) of those in the original conventional-treatment group, representing an 84% reduction in odds (95% CI, 67%-92%), compared with a reduction of 57% (95% CI, −1% to +81%) at the end of the DCCT. Fewer cases of hypertension (prevalence at year 8, 29.9% vs 40.3%; P&lt;.001) developed in the original intensive-treatment group. Significantly fewer participants reached a serum creatinine level of 2 mg/dL or greater in the intensive-treatment vs the conventional-treatment group (5 vs 19, P = .004), but there were no differences in mean log clearance values. Although small numbers of patients required dialysis and/or transplantation, fewer patients experienced either of these outcomes in the intensive group (4 vs 7, P = .36).ConclusionsThe persistent beneficial effects on albumin excretion and the reduced incidence of hypertension 7 to 8 years after the end of the DCCT suggest that previous intensive treatment of diabetes with near-normal glycemia during the DCCT has an extended benefit in delaying progression of diabetic nephropathy.
Table of Contents
Authors: Elena Perez, Jordan Orange, Francisco Bonilla, Javier Chinen, Ivan Chinn, Morna Dorsey, Yehia El-Gamal, Terry Harville, Elham Hossny, Bruce Mazer, Robert Nelson, Elizabeth Secord, Stanley Jordan, E Stiehm, Ashley Vo, Mark Ballow, St Petersburg
Journal: Journal of Allergy and Clinical Immunology (2017)
Some Physicians May Underestimate Bronchitis; Bronchoscopy Seems an Effective Means of Control
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PUBLIC PRESS COMMITTEE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal