tbuckley/cabot-search huggingface dataset:
Comparative effectiveness of first-line VEGF TKI followed by second-line therapy with either a VEGF TKI or an mTOR inhibitor in patients with metastatic renal cell carcinoma.
Authors: Shiven B. Patel, Srinivas Kiran Tantravahi, David Gill, Austin Poole, Joseph Merriman, Julia A. Batten, David D. Stenehjem, Neeraj Agarwal
Journal: Journal of Clinical Oncology (2015)

495 Background: In the INTORSECT trial, not progression-free (PFS), but overall survival (OS) was higher with sorafenib vs. temsirolimus in 2 nd setting after 1 st sunitinib therapy. Here, we compare the PFS and OS between any vascular endothelial growth factor inhibitor (VEGF TKI) and mTOR inhibitors (mTORi) in 2 nd setting in mRCC after progression on 1 st VEGF TKI. Methods: Pts were identified from an institutional database. Survival estimates of PFS and OS were assessed from initiation of 2 nd therapy by Kaplan-Meier methodology and stratified by the median PFS of the 1 st therapy. Results: Of 142 pts, 66 received a VEGF TKI (n=24, 36%) or an mTORi (n=42, 64%) in 2 nd setting. Pts and disease characteristics with corresponding outcomes are presented in the table. Conclusions: A trend for improved PFS and OS was found with 2 nd therapy with a VEGF TKI over an mTORi. Longer OS with 2 nd VEGF TKI was seen in those on 1 st VEGF TKI &lt;8 months suggesting that continued VEGF inhibition may be a reasonable strategy in these pts. Data need to be validated in a larger cohort. [Table: see text]
MOTTLED ENAMEL IN SEGREGATED POPULATIONS
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sexual education for adolescents
Authors: T. G. Esau
Journal: JAMA (1968)

An earnest young protestant seminary graduate has come to be an assistant minister in our suburban community. He wishes to undertake some sort of sexual education of the adolescent young people in the church, before they encounter the sexual temptations which are bound to arise in high school and college. If he undertakes this task in cooperation with one of the physicians in the congregation, what should be the role of each? Is it necessary to obtain the consent of the parents of the young people before such counseling is undertaken?
INCIDENCE OF ACUTE MYOCARDIAL INFARCTION AND HURRICANE KATRINA: FOURTEEN YEARS AFTER THE STORM
Authors: Daniel Harrison, Harsh Rawal, Matthew Quan, Ali Ayoub, Deep Sangani, Maelynn La, Matthew Kogan, Rogin Subedi, Anand Irimpen, Adedoyin Johnson
Journal: Journal of the American College of Cardiology (2021)
Phage Treatment of Severe Burns
Authors: A. G. Shera
Journal: BMJ (1970)

article on corneal disease (4 April, p. 33) states that surgical removal of a pterygium has a recurrence rate of some 50%.This, of course, used to be true.Mr. Cairns seems to be unaware of the fact that the use of eye drops consisting of a 1/2,000 solution of triethylene thiophosphoramide (Thio-Tepa) reduces the recurrence rate to less than 1 %1 .The drops are used every three hours during the waking period for six to eight weeks.The solution keeps its activity for at least two weeks if stored in a refrigerator and gives better results and none of the complications that can occur with beta-radiation therapy.-Iam, etc.,
Arteriotomy for Left Heart Catheterization in Children-G. S. Husson and M. S. Blackman
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rectal Cancer
Authors: _ _
Journal: Journal of the National Comprehensive Cancer Network (2007)

In 2007, an estimated 41,420 new cases of rectal cancer will occur in the United States (23,840 cases in men; 17,580 cases in women). The guidelines for rectal cancer overlap considerably with those for colon cancer, and the panel unanimously endorses patient participation in a clinical trial over standard or accepted therapy in both. This is especially true for cases of advanced disease and for patients with locally aggressive colorectal cancer who are receiving combined modality treatment. The latest updates of the NCCN Anal Carcinoma Clinical Practice Guidelines in Oncology are available online at www.nccn.org . For the most recent version of the guidelines, please visit NCCN.org
The prevalence of high blood cholesterol levels among adults in the United States
Authors: C. Sempos
Journal: JAMA (1989)

Using the National Cholesterol Education Program's Guidelines for the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults and the most recent nationally representative serum total cholesterol and lipoprotein data for adults (ages 20 to 74 years) from the second National Health and Nutrition Examination Survey (1976 to 1980), it is estimated that 41% of adults should have lipoprotein analysis after an initial measurement of serum total cholesterol. Furthermore, it is estimated that 88% of those who need lipoprotein analysis, or 36% of all adults aged 20 to 74 years, are candidates for medical advice and intervention for high blood cholesterol levels. We estimate, based on 1986 population data, that approximately 40 million Americans between the ages of 20 and 59 years are candidates for medical advice and intervention. An additional 24 million Americans aged 60 years and older are candidates. Overall, we estimate that about 60 million Americans aged 20 years and older are candidates for medical advice and intervention for high levels of blood cholesterol, although a less intensive approach might be appropriate for elderly patients. (<i>JAMA</i>. 1989;262:45-52)
DEFORMITIES OF THE VULVA FROM EARLY AND LATE INDURATING EDEMA.
Authors: ROBERT W. TAYLOR
Journal: JAMA (1907)

<h3>KRAUROSIS-LIKE CONDITION.</h3> In the early days of the previous case there were appearances which suggested that form of atrophy called kraurosis vulvæ. Now it is generally admitted that this affection begins in a quasi-inflammatory manner, with pain and pruritus and hyperemia of the mucous membrane, localized at first at the clitoris and urethral orifice, and from there extending in a serpiginous manner over the whole vulva. Very soon hyperplastic and atrophic changes set in. In one of my cases coincident with the subsidence of the infiltration, atrophy gradually developed and persistently progressed. In two years the large and small labia had nearly disappeared, and looked like atrophic tissue covered with membrane which resembled cracked or crumpled parchment of a dirty brown color. The structure of the mucosa was entirely obliterated. The vulva no longer protruded; the clitoris was obliterated; and the parts around the urethra and vagina were stenosed by
The transmission of AIDS: the case of the infected cell
Authors: J. A. Levy
Journal: JAMA (1988)

CURRENT approaches to preventing infection with the human immunodeficiency virus (HIV) have focused on the retrovirus itself. However, biologic and epidemiologic studies of HIV and the acquired immunodeficiency syndrome (AIDS) indicate that more emphasis should be placed on the virus-infected cell. Several groups of researchers<sup>1-10</sup>have demonstrated the presence of HIV in many different hematopoietic cells, including T and B lymphocytes and macrophages, as See also p 3023. well as in cells (macrophages and endothelial and glial cells) of the brain. These infected cells can survive and serve as reservoirs (factories) for continual virus production and spread. When found in body fluids, they can transfer the infection to other individuals. T-helper lymphocytes generally die after HIV infection,<sup>1-4</sup>but some can replicate HIV to high titer in culture without undergoing cell death.<sup>11</sup>Thus, they too could serve as a source of virus transmission. In studies from our laboratory,
Diagnostic and therapeutic technology assessment. Whole-body hyperthermia treatment of cancer
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heartpains
Authors: Joseph K. Izes
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE USES OF MEDICAL JOURNALS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Seventh Annual Meeting of Society for Clinical Trials
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Seventh Annual Meeting of Society for Clinical Trials Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 5, November 1985, Page 985, https://doi.org/10.1093/jnci/75.5.985-a Published: 01 November 1985
StatBite Breast Cancer Incidence in the U.S. and Italy
Journal: JNCI Journal of the National Cancer Institute (2011)

Breast cancer rates in the U.S. and Italy are similar in younger women but after about age 55, U.S. rates climb more steeply.Modifying individual risk factors-weight, alcohol consumption, and leisure physical activity-can reduce breast cancer risk, according to a new model based on Italian data and published in this issue of JNCI.The differences between Italy and the U.S. emphasize the need for models such as these to be created on the basis of local data, says an accompanying editorial.
Thyroid heart disease.
Journal: BMJ (1966)

discusses the environment in relation to accidents in old people (p.785).Poisoning with Medicine: Dr. H. Matthew stresses the doctor's responsibility to avoid over-prescribing and to warn his patients about dangerous drugs (p.788).Accidents in Industry: Professor R. C. Browne suggests modernizing the outlook on industrial health and recognizing the import- ance of making safety a habit (p
Spinal Cord Hypothermia Useful in Spasticity
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Caplin B, Yang C-W, Anand S, et al., on behalf of International Society of Nephrology’s International Consortium of Collaborators on Chronic Kidney Disease of Unknown Etiology (i3C). The International Society of Nephrology’s International Consortium of Collaborators on Chronic Kidney Disease of Unknown Etiology: report of the working group on approaches to population-level detection strategies and recommendations for a minimum dataset. Kidney Int. 2019;95:4–10
Journal: Kidney International (2019)
Renal Tuberculosis
Authors: John K. Lattimer
Journal: New England Journal of Medicine (1965)

THIS serious complication of tuberculosis can now almost always be controlled with nonoperative therapy. Persistent specific chemotherapy, combined with conscientious monitoring by cystoscopic, x-ray and laboratory examinations, has gradually permitted medicines to supplant the knife, in the years since 1946. Eighteen years of faithful follow-up observations on several hundred cases of this relatively rare disease by the Research Unit for Genitourinary Tuberculosis of the Kingsbridge Veterans Administration Hospital and the Columbia University Department of Urology appear to justify this position. For example, in one group of 333 patients in whom the effects of chemotherapy alone could be well evaluated, it . . .
ENDOCARDITIS AS A COMPLICATION OF MUMPS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Knowledge and perceptions of breast cancer risk in adolescent girls at high risk and population risk for breast cancer.
Authors: A. R. Bradbury, L. J. Patrick-Miller, L. Tuchman, C. Moore, P. Rauch, C. B. Sands, R. Shorter, B. Rowan, S. Malhotra, S. Van Decker, L. Bealin, H. Schmidheiser, M. B. Daly
Journal: Journal of Clinical Oncology (2011)

1581 Background: Evidence suggests that early events may influence or modify adult breast cancer (BC) risk. Little is known about how adolescents from breast cancer families understand, respond to and incorporate hereditary risk. Methods: 11-19 YO girls at high risk (HR) or population risk (PR) for BC completed semi-structured interviews informed by the Self-regulation Theory of Health Behavior. Study endpoints include knowledge and perceptions of BC risk and performance of health behaviors. Framework analysis was utilized to analyze interviews. Descriptive statistics were utilized to generate response proportions to close-ended items and coded data. Results: The mean age of girls (n==50) was 15.2 (SD2.1). 18 PR and 32 HR girls participated. 22% had a mother with a history of BC; 6 with a BRCA1/2 mutation in their family. Participants most frequently reported genetics or family history (70%) as the reason women develop BC. 58% of girls reported self-perceived risk for adult BC to be higher than other girls their age (81% of HR girls v. 17% of PR girls). 60% of girls felt that BC could occur in their family <40 YO; 18% reported that BC could occur <18 YO. 69% of girls reported that there are things women (67% HR v. 72% PR) and girls their age (60% HR v. 83% PR) can do to prevent BC. Girls reported learning of BC from their mother (90%), media (60%), school (52%), other family (48%), health care professionals (46%), internet (34%), BC awareness activities (22%) and friends (20%). Girls reported hearing about risks for BC from their mother (74%), school (28%), media (18%), and the internet (14%). Only 18% reported knowledge of BRCA1/2 genes. Conclusions: Many HR girls, and some PR girls, perceive themselves to be at increased risk for adult BC and believe that BC can occur in their family <40 YO. Most girls believe there are things that women and girls can do to prevent breast cancer. Mothers are a primary source of information regarding BC and risks for BC. Further research evaluating knowledge and perceptions of breast cancer risk throughout adolescent development could inform strategies to optimize adolescent psychosocial responses to hereditary cancer risk and promote preventive health behaviors among HR and PR girls.
Tuberculosis of the spine.
Journal: BMJ (1974)

Tuberculosis of the SpineSpinal tuberculosis is not yet a disease of the past.It is much commoner, even in Britain, than many of the bone tumours about which so much is written and argued, and in developing countries it is as rampant as it was in Britain 70 years ago.There is no consensus of opinion about its treatment except that it is agreed that chemotherapy is essential.Until recently, however, not even the potentialities of chemotherapy had been adequately explored-a state of affairs contrasting noticeably with that in pulmonary disease.In tuberculosis of the spine drugs had usually been used as adjuvants to established orthopaedic measures.Prolonged recumbency, splintage, and a variety of operations are still being used and are being justified more by assertion than by research.
Amphetamine Prescribing
Authors: D. W. Bracey
Journal: BMJ (1967)

those making impulsive suicidal attempts.By the time a sufficient dose of the analgesic drug has been extracted from its wrappings some of the emotional heat might have been dissipated, allowing time for wiser counsels to prevail.It is so very much easier to open a bottle of tablets and swallow the lot in one impulsive gesture than it is to unwrap labori- ously each pill carefully embedded in tinfoil.We would like to suggest, therefore, as a contribution to lessening the self-poisoning problem, that the drug firms should be asked to consider whether it would be possible to market all sedative and hypnotic drugs in this individually wrapped fashion.We do not know how such packaging compares in cost with the more conventional methods of supply in cartons and bottles, but it is possible that any additional cost would be more than compensated for by the saving of lives and expensive hospital treatment.-We are, etc.,