tbuckley/cabot-search huggingface dataset:
Corrections
Authors: Massimo Filippi, Federica Agosta, Julian Grosskreutz, Michael Benatar, Jan Kassubek, Esther Verstraete, Martin Turner
Journal: The Lancet Neurology (2015)

provide in-vivo evidence for progressive expansion of white matter damage from motor to extramotor networks.The NiSALS group supports future studies of larger patient populations to clarify the sensitivity of diff erent approaches.Inclusion of patients in the very early phase of the disease, including presymptomatic mutation carriers, 13 should be considered to minimise the challenge of longitudinal MRI assessment as bulbar and respiratory defi cits worsen.NiSALS is a thriving multinational, academicled research consortium.In view of the increasing complexity of the disorder, our multicentre approach with up-to-date, ultimately harmonised neuroimaging protocols will further improve understanding of ALS pathogenesis, and deliver objective biomarkers for use in multicentre therapeutic trials.
ICPM News Section
Authors: Marie J. Cowan, M. Walpoth, C. Hoertnagl, B. Mangweth-Matzek, Erkki Kronholm, Timo Partonen, Jouko K. Salminen, Aino K. Mattila, Matti Joukamaa, Giovanni A. Fava, Nicoletta Sonino, Kenneth E. Freedland, Matthew M. Burg, Gideon E. Anholt, Pieter Kempe, Else de Haan, Patricia van Oppen, Danielle C. Cath, Johannes H. Smit, Anton J.L.M. van Balkom, Cinzia Bressi, Stefano Manenti, Patrizia Frongia, Matteo Porcellana, Giordano Invernizzi, Patrice G. Saab, Marston E. Youngblood, Carol E. Cornell, Lynda H. Powell, Susan M. Czajkowski, Michael Linden, Kai Baumann, Max Rotter, Barbara Schippan, C.G. Kooiman, M.E. Raats, P. Spinhoven, Jan Scott, Francesc Colom, Glen I. Spielmans, Claudi L.H. Bockting, Mascha C. ten Doesschate, Jan Spijker, Philip Spinhoven, Maarten W.J. Koeter, Aart H. Schene, G. Kemmler, J. Hinterhölzl, A. Conca, A. Hausmann
Journal: Psychotherapy and Psychosomatics (2007)
Measurement of Exchangeable Magnesium in Dogs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obesity is associated with macrophage accumulation in adipose tissue
Authors: Stuart P. Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L. Leibel, Anthony W. Ferrante
Journal: Journal of Clinical Investigation (2003)

Obesity alters adipose tissue metabolic and endocrine function and leads to an increased release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity associated complications. To further characterize the changes that occur in adipose tissue with increasing adiposity, we profiled transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob). We found that the expression of 1,304 transcripts correlated significantly with body mass. Of the 100 most significantly correlated genes, 30% encoded proteins that are characteristic of macrophages and are positively correlated with body mass. Immunohistochemical analysis of perigonadal, perirenal, mesenteric, and subcutaneous adipose tissue revealed that the percentage of cells expressing the macrophage marker F4/80 (F4/80+) was significantly and positively correlated with both adipocyte size and body mass. Similar relationships were found in human subcutaneous adipose tissue stained for the macrophage antigen CD68. Bone marrow transplant studies and quantitation of macrophage number in adipose tissue from macrophage-deficient (Csf1op/op) mice suggest that these F4/80+ cells are CSF-1 dependent, bone marrow–derived adipose tissue macrophages. Expression analysis of macrophage and nonmacrophage cell populations isolated from adipose tissue demonstrates that adipose tissue macrophages are responsible for almost all adipose tissue TNF-α expression and significant amounts of iNOS and IL-6 expression. Adipose tissue macrophage numbers increase in obesity and participate in inflammatory pathways that are activated in adipose tissues of obese individuals.
Voluntary sterilization
Authors: A. R. Holder
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIAGNOSIS AND OPERATIVE TREATMENT OF GUNSHOT WOUNDS OF THE STOMACH AND INTESTINES.Read by Invitation in the Surgical Section of the Tenth International Medical Congress, August 8, 1890.
Authors: N. SENN
Journal: JAMA (1890)

(<i>Concluded from p. 363</i>.) 2.<i>Treatment of Gunshot Wounds of the Stomach and Intestines</i>. The propriety of surgical interference in cases of gunshot wounds of the stomach and intestines will depend on one of two things: 1. Dangerous internal haemorrhage. 2. Visceral wounds of the stomach or intestines large enough to permit of extravasation and the escape of hydrogen gas on applying the diagnostic test. Alarming intraperitoneal hæmorrhage furnishes an urgent indication for treatment by laparotomy irrespective of the existence of the visceral lesions of the gastro-intestinal canal. In these days of aggressive surgery it would indeed be unjustifiable to permit a patient to die slowly but surely from hæmorrhage from an intra-abdominal wound which in itself is amenable to successful treatment by prompt surgical means. The signs and symptoms of profuse internal hæmorrhage come on soon after the injury has been inflicted, and are so plain and significant
ERRATUM
Journal: Circulation (1950)

The following error was made in the article, "Some Effects of Digoxin upon the Heart and Circulation in Man: Digoxin in Cor Pulmonale," by Ferrer, Harvey, Cathcart, Webster, Richards, and Cournand, in the February issue of the Journal (Circulation 1: 161, 1950). In figure 7 (page 182), the arrow indicates that pulmonary hypertension leads to increased cardiac output. The reverse is, of course, the case; the arrow should have indicated that increased cardiac output leads to pulmonary hypertension.
Reliability and reversibility of female sterilisation.
Journal: BMJ (1978)

The technique of laparoscopy has become popular in Britain, requiring effective methods of occluding the tubes. High-frequency unipolar current, bipolar current and thermocoagulation are all very destructive procedures. A surgeon attempting reversal after electrocoagulation may find extensive tissue damage or other complications such as contact burns; when equally effecitve procedures are available, it becomes difficult to justify continued use of the method. A popular alternative is the variety of occlusive devices. The British Rocket clip has a failure rate of only about 2/1000, it destroys only about .3 cm of tube, and the applicator has a safety catch mechanism allowing removal before final closure if placement is in question. The silicone (Falope) ring causes infarction and obliteration of the lumen of the 2-3 cm of tube ensnared in the ring. Although the need to draw a loop of tube into the instrument delivering the ring has resulted in injuries to the tube and mesosalpinx, this has occurred less frequently with experience. Successful reversal after the use of these devices has been reported. Any study of reliability of a method of sterilization should consider the following variables: operator experience, the timing of the procedure, the route and technique used, the means of achieving occlusion, the site of tube selected, the method of analyzing results, and an account of the time of exposure when expressing failure rates. Pregnancies are most likely in the first 2 years, ectopic pregnancies are most likely with electrocoagulation, and 12-month life table pregnancy rates on data from 60 centers have shown identical rates of 2/1000 for laparoscopy and minilaparotomy. For both closure and reversibility the narrowest part of the tube is the best choice, and minilaparotomy using a Pomeroy operation or a device would have advantages over laparoscopy in underdeveloped societies. Now that devices have proved as effective as electrocoagulation, or surgical occlusion, they can be recommended by any route with preference give to those destroying the least tissue.
Postgraduate Medical Journal, London
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3866: Decursin inhibits tumor growth, migration and invasion through the regulation of CXCR7 expression in gastric cancer
Authors: Solbi Kim, Nayoung Kim, Mina Joo, HueungJin Jeon, Hyewon Ryu, Hyo Jin Lee
Journal: Cancer Research (2019)

Abstract Background: CXCR7 is overexpressed in a variety of cancer and is known to promote cell migration, invasion and metastasis. Therefore, inhibition of CXCR7 can prevent tumor progression. In this study, we investigated the role of decursin on the CXCR7 expression and its antitumor effects in gastric cancer. Methods: CXCR7-overexpressing gastric cell lines were established, and the expression of membrane CXCR7 was confirmed by flow cytometry and immunocytochemistry. Cell viability and anoikis assay were performed using CCK-8 reagent. The effect of decursin on cell migration and invasion was tested using transwell system, and the cleavage of PARP and caspase-3 was performed in western blotting and was confirmed by flow cytometry using apoptosis detection kit. The inhibition of tumor growth by decursin was also demonstrated in vivo by measuring tumor growth using subcutaneous injection mouse model. Results: CXCR7 overexpression significantly increased the invasion and migration, and tumor growth in gastric cancer cells. Administration of decursin decreased the membrane expression of CXCR7 in a concentration dependent manner and significantly inhibited tumor progression by suppressing cell migration, invasion and proliferation. In addition, decursin treatment impeded in vivo tumor growth in BALB/c nude mice. CXCR7-induced STAT3 and c-Myc activation were inhibited by decursin, whereas pro-apoptotic pathway was activated. Conclusion: Decursin inhibited the cell growth, migration and invasion via downregulating the membrane expression of CXCR7 in gastric cancer in vitro and suppressed tumor growth in vivo suggesting that decursin might be used as a therapeutic agent alone or in combination with other anticancer agents in gastric cancer. Citation Format: Solbi Kim, Nayoung Kim, Mina Joo, HueungJin Jeon, Hyewon Ryu, Hyo Jin Lee. Decursin inhibits tumor growth, migration and invasion through the regulation of CXCR7 expression in gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3866.
Smoking Cessation
Authors: Erin Brender, Cassio Lynm, Richard M. Glass
Journal: JAMA (2006)

Smoking CessationQ uitting smoking (smoking cessation) is one of the most important things you can do to improve your health and well-being.People who stop smoking decrease their risk of cancer, heart disease, stroke, and early death.Women who stop smoking before or during pregnancy reduce their risk of infertility or having a low-birthweight baby.Most smokers in the United States report that they want to stop smoking, but kicking the smoking habit can be difficult.Most ex-smokers try several times, often as many as 8 to 10 times, before they are able to quit for good.The results are definitely worth those efforts.The July 5, 2006, issue of JAMA includes articles about varenicline, a new drug treatment aimed at helping patients to quit smoking and to remain smoke-free.
Occupational and Environmental Health Hazards in the Plastics Industry
Authors: Robert E. Eckardt
Journal: Environmental Health Perspectives (1976)

A brief description of the potential occupational health hazards encountered in the manufacture of plastics (polymers) is given. In general, these hazards are due to the monomers used to make the various plastics, to unreacted monomer contained within the finished products, and to the fillers, stabilizers, pigments, inhibitors, and initiators used in fabricating the finished products. They run the gamut from angiosarcomas of the liver due to vinyl chloride, to dermatitis and asthma-like reactions due to the initiators used with epoxy resins.
Proper Doctoring
Authors: Thomas H. Lewis
Journal: JAMA (1985)

"This book owes very little to the written word. The opinions found in it are my own, and I learned many of them from my teachers by word of mouth." The pages of Dr Mendel's manual fulfill these introductory sentences, giving the thoughts gathered from the consulting room and hospital ward. A sampling of the topics might include learning to "play the role" of doctor, self-control, always remembering that one is "in service" to satisfy, attitudes toward colleagues, taking a history gracefully, performing an examination without offending, how to consider the gathering of test data, how to give advice, and how to deal with questions that are embarrassing to the physician and the patient. Some of the suggestions are surprising ("patients have backs which repay examination," "when the patient is in the ward there may be no necessity to make notes of changes in his condition or of the treatment
Degranulation deconstructed
Authors: Robert L. Baehner, Morris J. Karnovsky
Journal: Journal of Clinical Investigation (2012)

Pediatricians first described the clinical features of chronic granulomatous disease (CGD) in 1959. Almost a decade later, in a collaborative effort that crossed disciplines, we participated in the discoveries that defined the cellular deficiencies of CGD, specifically finding that improper degranulation of leukocytes did not explain their failure to fight pathogens, rather that the fundamental defect was due to problems in the unique NADPH oxidase system of phagocytizing leukocytes. In the years that followed, the subunit components and structure of NADPH oxidase and their translocation during leukocyte phagocytosis to form the active enzyme were well described, leading to the identification of the component genes, the mapping of their chromosomal locations, and their subsequent cloning. This remarkable progress has led to effective therapies, including bone marrow transplants and gene therapy, that would have been unimaginable when we began.
<i>QuickStats: </i>Age-Adjusted Rate* for Suicide,<sup>†</sup> by Sex — National Vital Statistics System, United States, 1975–2015
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

There was an overall decline of 24% in the age-adjusted suicide rate from 1977 (13.7 per 100,000) to 2000 (10.4). The rate increased in most years from 2000 to 2015. The 2015 suicide rate (13.3) was 28% higher than in 2000. The rates for males and females followed the overall pattern; however, the rate for males was approximately 3-5 times higher than the rate for females throughout the study period.
P155 Safety of tiotropium respimat® add-on therapy in patients aged 6–17 years with symptomatic asthma
Journal: Thorax (2016)

AbstractC Vogelberg has participated in an advisory board for Boehringer Ingelheim; SJ Szefler has received personal fees from Aerocrine, Boehringer-Ingelheim, Daiichi Sankyo, Genentech, GlaxoSmithKline, Merck, Novartis, and Roche, and research grants from GlaxoSmithKline; E Hamelmann has received research grants and other fees from Boehringer Ingelheim and non-financial support from Boehringer Ingelheim; A Boner has nothing to disclose; P Moroni-Zentgraf is an employee of Boehringer Ingelheim; M Engel is an employee of Boehringer Ingelheim; G El Azzi is an employee of Boehringer Ingelheim; H Finnigan is an employee of Boehringer Ingelheim; M Vandewalker has received research grants and personal fees from Boehringer Ingelheim.
Depletion of the C3 Component of Complement Enhances the Ability of Rituximab-Coated Target Cells to Activate Human NK Cells and Improves the Efficacy of Monoclonal Antibody Therapy in An in Vivo Model
Authors: Siao- Yi Wang, Jeffrey Cagley, David Fritzinger, Carl-Wilhelm Vogel, William St. John, George J Weiner
Journal: Blood (2008)
Autologous Transfusion
Authors: J. Garrott Allen
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In his LETTER (<b>216</b>: 1037, 1971), Milles makes a good point that autologous transfusion of blood should produce no hepatitis. This procedure was used in the 1930s by Dr. William Deichman, professor of obstetrics and gynecology at the University of Chicago, as a method of minimizing transfusion reactions in pregnant women. In the 1950s it was reintroduced by Dr. William Lees, head of thoracic surgery at Loyola. Lees employed the patient as his own donor primarily in elective thoracic surgery cases. If there is any reason that this excellent procedure has not been used more extensively, it is because there are so many diseases in which a patient is given transfused blood which occur when he has become too ill to serve as his own donor, ie, trauma, cancer, acute vascular accidents, and acute infections. When the patient can serve as his own donor, he should be
THE INTESTINE AS AN EXCRETORY ORGAN
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recurrent Salmonella typhi peritonitis
Authors: R. H. Eng
Journal: JAMA (1980)

<i>SALMONELLA typhi</i>peritonitis is rarely seen in the United States today.<sup>1</sup>Recently the incidence of typhoid in the United States has been 0.2 cases per 100,000 people per year, with one third of the cases attributed to foreign travel.<sup>2</sup>In older series 2% of patients with typhoid had perforation of viscera and peritonitis. At the Kings County Hospital Center, four cases of typhoid were seen in 1977 and 1978. All were recent immigrants from the Caribbean. Among these patients one had peritonitis and an unusual course. <h3>Report of a Case</h3> The patient was a 19-year-old Haitian who came to the United States in January 1975. While in Haiti in November 1974, she was hospitalized for vomiting, abdominal pain, constipation, and high fevers. She was told she had typhoid fever and was treated with nasogastric tube decompression and 28 days of chloramphenicol therapy. She recovered uneventfully. Four months later,