tbuckley/cabot-search huggingface dataset:
“Focus on…” Session: radiotherapy and early stage
Authors: P Hoskin, L Lowry, P Smith, W Qian, S Falk, K Benstead, T Illidge, M Robinson, A Jack, D Linch, J Friedberg, M Byrtek, B Link, C Flowers, M Taylor, J Hainsworth, J Cerhan, J Hirata, T Miller
Journal: Annals of Oncology (2011)
Keeping up with Cancer
Journal: CA A Cancer Journal for Clinicians (1955)

Cancer and the Law posed to suhcarcinogenic agents.such as solar and ionizing radiation, coal tar, pe.troleum oils, and arsenic.Bacillary or amehic dysentery or schistosomiasis is a, reasonable possibility in the etiology of subsequent carcinoma of the intestine.Environmental pollutants of air, water, soil, and foodstuffs, such as aromatic amines, beryllium, soot, etc., must be given medicolegal consideration concern ing the liability of cancer development among the general population.In the con sideration of compensation claims, the older concept of traumatic cancer is being replaced by the more factual concepts of environmental cancer. 1-Iue,'er, JV. ( .: @l('(II(UIeg(II (1S@('((S of corner. â€˜¿ iUt.
TREATMENT OF REFRACTORY TRAUMATIC SHOCK
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vitamin D status and survival of metastatic colorectal cancer patients: Results from CALGB/SWOG 80405 (Alliance).
Authors: Kimmie Ng, Alan P. Venook, Kaori Sato, Chen Yuan, Bruce W. Hollis, Donna Niedzwiecki, Cynthia Ye, I-Wen Chang, Bert H. O'Neil, Federico Innocenti, Heinz-Josef Lenz, Charles David Blanke, Robert J. Mayer, Charles S. Fuchs, Jeffrey A. Meyerhardt
Journal: Journal of Clinical Oncology (2015)

3503 Background: Prospective epidemiologic data suggest that higher levels of 25-hydroxyvitamin D [25(OH)D] are associated with improved survival in patients with colorectal cancer, however the relationship between 25(OH)D and outcome in metastatic CRC (mCRC), specifically, is unknown. Methods: We prospectively assessed the association between plasma 25(OH)D and overall survival (OS) in previously untreated mCRC patients enrolled in CALGB/SWOG 80405, a randomized phase III trial of chemotherapy + bevacizumab, cetuximab, or both, prior to the KRAS wild type amendment. Progression-free survival (PFS) was a secondary endpoint. Plasma 25(OH)D levels were measured at baseline by radioimmunoassay, and dietary and lifestyle behaviors collected from self-administered questionnaires. Cox proportional hazards models were used to calculate hazard ratios (HR) adjusted for other prognostic variables. Results: Among 1,043 patients, median plasma 25(OH)D was 17.2 ng/mL (range 2.2-72.7). Male and black patients, those living in the northeast, patients with lower dietary and supplemental vitamin D intake, ECOG performance status 1 (vs. 0), tumoral RAS mutation, higher body-mass index, lower physical activity, and blood draw during the winter and spring had significantly lower levels of 25(OH)D. Patients in the highest quintile of 25(OH)D had significantly improved OS compared to those in the lowest after adjusting for pathologic and clinical prognostic factors (median 32.6 vs. 24.5 months; HR 0.65, 95% CI, 0.51-0.83; P trend = 0.001). Increasing concentrations of 25(OH)D were also significantly associated with improved PFS (median 12.2 vs. 10.1 months; HR 0.79, 95% CI, 0.63-0.99; P trend = 0.01). The results were consistent across subgroups of patient characteristics, including RAS status, and remained unchanged after excluding patients who died within 3 or 6 months of blood draw. Conclusions: Higher concentrations of plasma 25(OH)D are associated with significantly improved survival in mCRC patients treated with chemotherapy + biologics. Randomized trials of vitamin D supplementation are warranted and ongoing, and effect modification by SNPs in vitamin D pathway genes is currently being explored.
Low serum interleukin-2 receptor levels correlate with a good prognosis in patients with Hodgkin’s lymphoma
Authors: Angela Gause, Volker Roschansky, Astrid Tschiersch, Kleri Smith, Dirk Hasenclever, Rudolf Schmits, Volker Diehl, Michael Pfreundschuh
Journal: Annals of Oncology (1991)
In vitro alternatives for ocular irritation.
Authors: R D Curren, J W Harbell
Journal: Environmental Health Perspectives (1998)

The necessity of using animals to test whether new chemicals and products are eye irritants has been questioned with increasing frequency and fervor over the last 20 years. During this time many new nonanimal methods have been proposed as reliable alternatives to the traditional rabbit (Draize) test. To date, however, none of these nonanimal (in vitro) tests have become universally accepted as a complete replacement for the Draize test. To understand why a complete replacement has not been found, one has to first understand the reasonably complex structure of the eye, the standard Draize scoring scale--which is based on a qualitative evaluation of three different tissues--the differences between human and rabbit eyes, the intrinsic variability of the animal test, and the details of the different in vitro tests that have been proposed as replacements. The in vitro tests vary from relatively simple assays using single cells to more sophisticated assays that use discarded animal tissue or artificially constructed human tissue. It is clear that appropriately designed in vitro tests will eventually give more useful mechanistic information about ocular injury from which we can more comfortably predict the risk of human eye irritation from new products and ingredients.
Human Occupational and Nonoccupational Exposure to Fibers
Authors: Nurtan A. Esmen, Serap Erdal
Journal: Environmental Health Perspectives (1990)

Human exposure to fibers in occupational and nonoccupational environments has been a health concern for nearly a century. In this review, selected results from the literature are presented to highlight the availability, limitations, and interpretive difficulties associated with the past and current human fiber exposure data sets. In the traditionally defined asbestos fibers, large amounts of the data available suffer from the diversity of sample collection and analysis methods. Two simple generalizations suggest that occupational exposures are several orders of magnitude higher than that of environmental exposures; and currently extant data and the current routine measurement practices present significant difficulties in the consistent interpretation of the data with respect to health effects. The data on the human exposures to man-made vitreous fibers are much more complete than the data on asbestos exposure, while exposure data on other man-made fibrous materials are lacking. The human exposure data to many minerals which, at times, exist in fibrous habit, are very scanty, and in view of the biological activity of some of these fibers, this lack may be of significant concern.
Late Gestational Influences May Alter Heart Size, Myocardial Fibers
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Index-Catalogue of the Library of the Surgeon-General's Office, United States Army.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency Care
Authors: John B. McCabe
Journal: JAMA (1979)

<h3>To the Editor.—</h3> As a fourth-year medical student planning to enter a residency in emergency medicine, I found the article by Fischer et al, "Direct Transfer to Operating Room Improves Care of Trauma Patients: A Simple, Economically Feasible Plan for Large Hospitals" (240:1731, 1978), to be somewhat disturbing. It seems to display a complete disregard for the field of emergency medicine. Although the authors' approach is one solution to the problem of "inept resuscitation and delays in diagnosis and treatment," an equally valid approach not mentioned is the use of appropriately trained medical staff in the emergency room. Apparently the role of the emergency department staff in their hospital is to "triage," "transport patients onto the operating table," and to give "cursory" examinations. There appears to be no role for the initiation of life-sustaining resuscitation by a well-trained emergency department staff. Despite the quick transport to the operating room, most
Q Fever in Ontario
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contractile protein phenotypic variation during development
Authors: A. M. Murphy
Journal: Cardiovascular Research (1996)

A diverse set of contractile protein genes and alternatively spliced isoforms is expressed during the process of cardiac maturation. A large variety of functional sarcomeric units may occur at various stages of development, in different regions of the heart and in pathologic states. In this review, the developmental program of individual contractile protein gene families is discussed with an emphasis on the functional effects of maturational changes, particularly in the human myocardium.
The Industrial Production and Use of 1,3-Butadiene
Authors: Norman L. Morrow
Journal: Environmental Health Perspectives (1990)

This presentation provides a brief overview of the production and use of 1,3-butadiene in the United States. Starting as a coproduct of ethylene, the 1,3-butadiene monomer is extracted and purified, then transferred to consumers. Major uses of 1,3-butadiene include the manufacture of styrene-butadiene rubber, polybutadiene rubber, and adiponitrile.
RESISTANCE TO PNEUMOCOCCUS INFECTION IN RABBITS FOLLOWING IMMUNIZING INJECTIONS OF HEAT-KILLED PNEUMOCOCCUS SUSPENSIONS
Authors: Ernest G. Stillman, Kenneth Goodner
Journal: The Journal of Experimental Medicine (1933)

On pages 202 and 205, Vol. 58, No. 2, August 1, 1933, the cuts for Text-figs. 2 and 3 should be interchanged. The cut on page 202 is Text-fig. 3, and should appear on page 205. The cut on page 205 is Text-fig. 2, and should appear on page 202. The legends should remain on the pages where they now appear.
Radiologie de la vésicule biliaire: Etude anatomique, fonctionnelle et clinique
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Yan Wang, Arun J. Sanyal
Journal: Hepatology (2017)

Potential conflict of interest: Dr. Sanyal consults and received grants from Intercept, Allergan, and Gilead. He consults for GenFit, Echosens, Merck, GE, Novartis, Pfizer, and Nitto Denko. He received grants from Sequana. He owns stock in Sanyal Bio. Author names in bold designate shared co‐first authorship. We appreciate Drs. Safiri and Ayubi's interest in our work. However, the concerns that seem based on a partial view of this study may need to be addressed here. In this proof‐of‐concept study,1 we explored use of a dual‐photon microscopy–based methodology to quantitate histological hepatic fibrosis in progressive nonalcoholic fatty liver disease. The hypothesis was based on prior research publications about this technology2 and its applications for measuring fibrosis in other chronic liver diseases.3 The research strategy was to identify the nonalcoholic fatty liver disease fibrosis highly related quantitation of fibrosis‐related parameters (q‐FPs) among the q‐FP set detected by dual‐photon technology and then use them to build a new function model with a desirability function5 to predict the fibrosis stages on a continuous scale with reference to the standard nonalcoholic steatohepatitis Clinical Research Network histology. To rigorously test the performance of the selected q‐FPs and the new desirability function model, an independent cohort was finally used for an additional validation. The proposed confidence interval issues are related to the first part of q‐FP selection. Based on preliminary correlation data between q‐FPs and standard histology, the sample size used for establishment was 50 subjects. Therefore, as anticipated, there was a wide confidence interval for the individual q‐FPs. However, emphasizing the importance of a narrow confidence interval but overlooking the other meaningful statistical variables in the context of a medical test study can be inappropriate. The numeric values of odds ratio and P value for all selected q‐FPs can together help to validate the power of related conclusions. Moreover, various modeling approaches and the sequential parts of this systematic study all verified the validities of the selected four q‐FPs for use in building a new desirability function model. In addition, we appreciate the recommendation of other sophisticated statistical approaches to testing the diagnostic performance. Addressing the purpose of this study, we only included the routine but well‐regarded approaches. We will consider the proposed ones in the future. As we discussed in the article,1 this study is about an initial step for the development of a new quantitative method, but it surely warrants further refinement including larger data sets and a longitudinal testing cohort.
Advances in Mechanisms of Activation and Deactivation of Environmental Chemicals
Authors: Joyce A. Goldstein, Michael B. Faletto
Journal: Environmental Health Perspectives (1993)

Environmental chemicals are both activated and detoxified by phase I and phase II enzymes. The principal enzymes involved in phase I reactions are the cytochrome P-450s. The phase II enzymes include hydrolase and the conjugative enzymes such as glucuronyltransferases, glutathione transferases, N-acetyltransferase, and sulfotransferase. Although other phase I and phase II enzymes exist, the present review is limited to these enzymes. Once thought to be a single enzyme, multiple cytochrome P-450 enzymes have been purified and characterized from many different species across the evolutionary tree. The application of molecular biology techniques to this field has identified more than 150 cytochrome P-450 genes to date. At least 20-30 cytochrome P-450 enzymes appear to exist in each mammalian species, and many polymorphisms in these enzymes are being identified. The cytochrome P-450 enzymes can now be expressed in recombinant form using cDNA expression systems. The phase II conjugative enzymes add a hydrophilic moiety such as sulfate, glucuronide, or acetate to compounds, which increases their water solubility and facilitates their excretion. However, conjugates of a number of compounds also result in more reactive electrophilic species, which appear to be the ultimate carcinogens. Many of these phase II enzymes also represent families of enzymes, and polymorphisms can affect the ability of these enzymes to metabolize chemicals. Whenever possible, we have reviewed knowledge of the human enzymes involved in particular pathways.
Antidiuretic Hormones
Authors: WILBUR H. SAWYER, ROBERT A. MUNSICK, H. B. VAN DYKE
Journal: Circulation (1960)

There are at least 3 antidiuretic hormones. Arginine vasopressin is the antidiuretic hormone of most mammals, including man. This function is served by lysine vasopressin in the pig, and by arginine vasotocin in birds, reptiles and amphibians. All 3 hormones are closely related chemically and act on the kidney in a similar manner. Arginine vasotocin also exists in fish, in which the antidiuretic response is not known to occur. This antidiuretic hormone appeared, therefore, in vertebrate phylogeny before it acquired antidiuretic function. Anatomic considerations suggest that the fish neurohypophysis serves to regulate adenohypophysial secretion. There is evidence that such a primitive type of neurohypophysial function has persisted throughout subsequent vertebrate evolution.
Error in Table, Methods Section, and Supplement
Journal: JAMA Network Open (2019)

Eui Jin Hwang, MD; Sunggyun Park, MS; Kwang-Nam Jin, MD; Jung Im Kim, MD; So Young Choi, MD; Jong Hyuk Lee, MD; Jin Mo Goo, MD, PhD; Jaehong Aum, PhD; Jae-Joon Yim, MD; Julien G. Cohen, MD; Gilbert R. Ferretti, MD; Chang Min Park, MD, PhD; for the DLAD Development and Evaluation Group
Mind-Body Medicine Explored at APA Meeting
Authors: L. Lamberg
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal