tbuckley/cabot-search huggingface dataset:
Phase II study of capecitabine in substitution of 5-FU in the chemoradiotherapy regimen for patients with squamous cell carcinoma of the anal canal.
Authors: Suilane Coelho Ribeiro, Camila Motta Venchiarutti Moniz, Rachel Riechelmann, Giovanni Mendonca Bariani, Maria Ignez Braghiroli, Caio Nahas, Renata Coudry, Alexandra Khichfy Alex, Allyne Q. Carneiro, Daniela R. Nebuloni, Joao Glasberg, Paulo Hoff
Journal: Journal of Clinical Oncology (2014)

560 Background: Squamous cell carcinoma (SCC) of the anal canal is an uncommon malignancy accounting for 1-5% of intestinal tumors; however, its incidence has been increasing. Treatment for stage II and III anal canal SCC is infusional 5-fluorouracil associated with mitomycin and radiotherapy, since 1974. More convenient treatments for patients are needed. Methods:Patients with SCC of anal cancer T2-4N0M0 or T (any) N1-3M0, with good performance status, normal blood, and renal function were treated with capecitabine 825 mg/m2 12/12hs during radiotherapy associated with a single dose of mitomycin 15 mg/m2 on day 1. Primary objective was local control rate at 6 months determined by clinical examination and radiological assessment. Sample size was calculated using Fleming single stage design. Results: From November/2010 to August/2013 42 patients were initially included, however 36 patients were assessed. Fifteen patients (41.7%) were stage II, 8 patients (22.2%) stage IIIA, and 13 patients (36.1%) stage IIIB. Four patients (11.1%) were HIV-positive, while 32 (88.9%) were HIV-negative. Thirty-two patients finished the treatment, 4 patients are still in treatment. Median follow-up was 18.7 months. Among patients who finished the treatment and were reevaluated at 6 months 4 patients (13.3%) presented partial response, 25 patients (83.3%) had complete response, and 1 patient developed liver metastasis (3.3%). Regarding grade 3-4 toxicities, 7 patients (21.8%) had grade 3 radiodermitis, 1 patient (3.1%) had grade 3 diarrhea, 2 patients (6.2%) had grade 3-4 thrombocytopenia, 3 (9.3%) had lymphopenia and one patient had grade 3 leukopenia. One HIV+ patient had septic shock, pneumonia, herpetic encephalitis and macrophage activation syndrome. Colostomy was required in 2 patients before the beginning of the treatment and 2 patients after the treatment because of local failure, corresponding to a colostomy rate of 12.5%. Conclusions: Capecitabine and mytomicin with radiotherapy seem to be a safe treatment for SCC of the anal cancer.
Parkinson Update
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Activation of fetal promoters of insulinlike growth factors II gene in hepatitis C virus-related chronic hepatitis, cirrhosis, and hepatocellular carcinoma
Authors: G Nardone
Journal: Hepatology (1996)

Increased prevalence of hepatitis C virus (HCV) infection has been found in patients with hepatocellular carcinoma (HCC). The expression of insulinlike growth factor II (IGF-II) has been linked to hepatocarcinogenesis in the experimental animal and in humans. Since reactivation of fetal IGF-II transcripts has been observed in human HCC, we have analyzed the levels of adult P1 and fetal P3 and P4 IGF-II promoter-derived transcripts in the liver of patients with HCV-related chronic active hepatitis (CAH), cirrhosis, and HCC by means of a semiquantitative reverse-transcription polymerase chain reaction (RT-PCR) assay. Transcripts derived from adult P1 promoter were increasingly expressed from normals to patients with CAH and cirrhosis, but were undetectable in the tumorous area of 5 of 7 HCC patients and present at low levels in the nontumorous area of all HCC patients. Transcripts derived from fetal P3 promoter were not detectable in normal subjects, while they were expressed abundantly in most CAH and all cirrhotic patients. Transcripts from fetal P4 promoter were detected at high levels in 3 of 9 CAH patients and in the majority of cirrhotic patients. Increased expression of fetal promoter-derived transcripts was also found in the liver of HCC patients, although levels were lower than in cirrhosis. Also, the activity of fetal P3 and P4 promoters was higher in the nontumorous than in the tumorous area of the liver of HCC patients. The expression of IGF-II transcripts was correlated with the rate of cell mitotic activity by measuring the expression of the proliferating cell nuclear antigen (PCNA) gene. PCNA messenger RNA (mRNA) levels progressively increased from normals to CAH and to cirrhotic patients, and persisted at a high level in the tumorous and in the nontumorous area of HCC subjects, thus showing that the increase of IGF-II transcripts in CAH and cirrhosis is accompanied by an activation of cell mitosis in these samples. These data suggest that the activation of IGF-II gene expression from adult and fetal promoters may play a role in premalignant proliferation observed in HCV-related chronic liver disease.
Reply
Authors: Noemi Lois, Ahmed Saad, Daniela Vaideanu-Collins, Augusto Azuara-Blanco, Caroline Styles, Christine McNally, Andrew Jackson, Rachael Rice, Clare Bailey, Danny McAuley, David H. Steel, Clair Barbour, Leontia Bell, Faruque D. Ghanchi, Zeid Madanat, Geeta Menon, Manju Chandran, Sely Mathews, Mohammed Galal, Haralabos Eleftheriadis, Stefanos Efraimidis, Jonathan Cook, Ariel Wang, William Sones, Lindsay Prior, Nachiketa Acharya, Noemi Lois, Norman Waugh, Hema Mistry, Mandy Maredza, Samia Fatum, Janette Savage, Sobha Sivaprasad, Stephen Aldington, Peter H. Scanlon, Katerina Ivanova, Tariq M. Aslam, Zaria Ali, Victor Chong
Journal: Ophthalmology (2021)
EXPERIMENTATION ON CONDEMNED CRIMINALS.
Journal: JAMA (1994)

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CLINICAL MANAGEMENT
Journal: JAMA (1964)

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Lung carcinoma in young adults
Authors: J. S. Putnam
Journal: JAMA (1977)

Twenty-four patients less than 40 years of age were diagnosed at Walter Reed Army Medical Center between 1971 and 1976 as having lung cancer. The youngest patient was 19 years old. Only one was a nonsmoker. Most patients were symptomatic at the time of examination. The chest roentgenogram showed an infiltrate or consolidation in 9, a mass lesion in 13, and a pleural effusion in 1. Thirty-eight percent had adenocarcinoma, 21% had squamous cell carcinoma, and 21% large cell carcinoma. Nineteen patients had stage II or III disease at the time of initial examination, and only six had resectable tumors. Survival rates were poor. (<i>JAMA</i>238:35-36, 1977)
Editorial: Pathogenesis of motor neurone disease.
Journal: BMJ (1975)

NarcolepsyThe narcoleptic syndrome is not uncommon, though its prevalence in Britain is not known for certain.A recent con- servative estimate' puts the inumber of narcoleptics in the U.S.A. as 100 000.The apparent slight male preponderance may wellbe due to its more disabling nature in men than women, and the actual sex incidence is probably equal.A third of patients have one or more affected relatives, usually on 17 July 2023 by guest.
PHYSICIANS DO NOT APPROVE OF CHLOROFORMING THE HELPLESS.
Journal: JAMA (1906)

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National Influenza Vaccination Week — December 6–12, 2015
Authors: Carla Mercado, Ariadne Desimone, Erika Odom, Cathleen Gillespie, Carma Ayala, Fleetwood Loustalot, Thomas Frieden, Harold Jaffe, Joanne Cono, Chesley Richards, Michael Iademarco, Sonja Rasmussen, Charlotte Kent, Jacqueline Gindler, Teresa Rutledge, Douglas Weatherwax, Soumya Dunworth, Teresa Hood, Martha Boyd, Maureen Leahy, Julia Martinroe, Stephen Spriggs, Moua Yang, Quang Doan, Phyllis King, Teresa Moreland, Terraye Starr, Timothy Jones, Matthew Boulton, Virginia Caine, Katherine Daniel, Jonathan Fielding, David Fleming, William Halperin, King Holmes, Robin Ikeda, Rima Khabbaz, Phyllis Meadows, Jewel Mullen, Jeff Niederdeppe, Patricia Quinlisk, Patrick Remington, Carlos Roig, William Roper, William Schaffner, Meghan Lyman, Maroya Walters, David Lonsway, Kamile Rasheed, Brandi Limbago, Alexander Kallen, Caitlin Pedati, Jennifer House, Jessica Hancock-Allen, Leah Colton, Katie Bryan, Dustin Ortbahn, Lon Kightlinger, Kiersten Kugeler, Jeannine Petersen, Paul Mead, Tom Safranek, Bryan Buss
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

The U.S. Department of Health and Human Services, CDC, state and local health departments, and other partners will observe National Influenza Vaccination Week (NIVW) during December 6-12, 2015, with educational and promotional activities across the country.
EXAMINATIONS FOR APPOINTMENT IN THE UNITED STATES ARMY.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bronchopancreatic fistula following traumatic rupture of the diaphragm
Authors: C. L. Cox
Journal: JAMA (1977)

A bronchopancreatic fistula developed in a 14-year-old boy two weeks following transabdominal splenectomy and repair of a ruptured diaphragm. This unusual entity should be suspected when a patient with pancreatitis or pancreatic trauma has pleural complications associated with profuse, frothy sputum. The diagnosis is established by the presence of high levels of amylase in the sputum or by the appearance in the sputum or the bronchi of dye or contrast material injected into the external fistula. The primary goal of treatment, in addition to the management of the thoracic complications, is subdiaphragmatic control of the pancreatic fistula. A brief summary of seven previously reported cases is presented. (<i>JAMA</i>237:1461-1463, 1977)
Quarterly J Experimental Physiology, Edinburgh
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats</i>: Rates of Drug Overdose Deaths Involving Heroin,* by Selected Age Groups — United States, 2006–2015
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

The rate of drug overdose deaths involving heroin increased slightly during 2006-2010 but more than tripled during 2010-2015 for all age groups shown. During 2010-2015, the rates increased from 1.2 to 3.8 per 100,000 for persons aged 15-24 years, from 2.2 to 9.7 for persons aged 25-34 years, from 1.6 to 7.4 for persons aged 35-44 years, from 1.4 to 5.6 for persons aged 45-54 years, and from 0.7 to 3.4 for persons aged 55-64 years. In 2015, the rate of drug overdose deaths involving heroin was highest for persons aged 25-34.
Insulin-dependent diabetes mellitus as an autoimmune disease
Authors: J. F. Bach
Journal: Endocrine Reviews (1994)

DIABETES mellitus is simply defined on the basis of hyperglycemia. It is, however, a highly heterogeneous disease. A major advance was made in the late 1960s when insulin-dependent diabetes mellitus (IDDM, type 1) was distinguished from non-insulin-dependent diabetes mellitus (NIDDM, type 2). Another milestone was the realization in the 1970s that in most cases IDDM has, presumably, an autoimmune origin (1–4). This offered new clues to the etiology and elicited hopes of immunoprevention, which is still the ultimate goal of research in the immunology of IDDM. This review will attempt to cover the major pending questions on the origin of the autoimmune process that leads to IDDM and will discuss in some depth genetic predisposition and environmental factors, the interaction of which creates the conditions required for disease onset. This will be followed by a characterization of the anti-β-cell immune response and the mechanisms by which the β-cell lesion is induced.
BUENOS AIRES
Journal: JAMA (1931)

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Transactions of the International Conference on Sanitary Engineering, London—1924.
Journal: JAMA (1925)

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Clinical Cardiology
Authors: Irwin R. Callen
Journal: JAMA (1982)

This is the third edition of a superb introduction to cardiology. However, there is a question of importance to be answered. Do we really need another edition so soon since the last one was published in 1978—an edition, incidentally, I also had the privilege of reviewing forThe Journal? In the preface the authors state that "the large amount of published research in cardiology... encouraged us to make a thorough revision for this third edition." They are correct concerning the volume of cardiology literature, but this is no justification for a book of this type (essentially a primer, albeit a good one). Another few years would be required for anyone owning the second edition to justify replacing it with the revised version. Again in the preface, "major revisions are in the chapters on cardiac physiology, non-invasive investigations, coronary disease and congenital heart disease." Chapter 11 covers congenital heart disease, and