Rejuvenation in Older Adults Receiving Oral Ghrelin
Authors: Ralf M. Nass
Journal: Annals of Internal Medicine (2009)

Letters5 May 2009Rejuvenation in Older Adults Receiving Oral GhrelinRalf M. Nass, MD, Mary Lee Vance, MD, and Michael O. Thorner, MBBS, DScRalf M. Nass, MDFrom University of Virginia Health System, Charlottesville, VA 22908.Search for more papers by this author, Mary Lee Vance, MDFrom University of Virginia Health System, Charlottesville, VA 22908.Search for more papers by this author, and Michael O. Thorner, MBBS, DScFrom University of Virginia Health System, Charlottesville, VA 22908.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-9-200905050-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the thoughtful comments in response to our article and offer some clarifications.We believe that aging is not a disease but a complex multisystem decline that occurs over decades. It is likely that MK-677 acts at multiple sites, including the hypothalamus, the pituitary, and the periphery. We have no evidence that atherosclerosis impairs its action.We did not perform other cancer screening in these healthy older adults. Women were carefully monitored with Papanicolaou smears and mammography, and prostate-specific antigen was monitored in men. Adverse effects were reported in the Results section. A study of this size ...References1. Critical evaluation of the safety of recombinant human growth hormone administration: statement from the Growth Hormone Research Society. J Clin Endocrinol Metab. 2001;86:1868-70. [PMID: 11344173] MedlineGoogle Scholar2. Kosek DJ, Kim JS, Petrella JK, Cross JM, Bamman MM. Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. J Appl Physiol. 2006;101:531-44. [PMID: 16614355] CrossrefMedlineGoogle Scholar3. Welle S, Thornton C, Statt M. Myofibrillar protein synthesis in young and old human subjects after three months of resistance training. Am J Physiol. 1995;268:422-7. [PMID: 7900788] MedlineGoogle Scholar4. Slivka D, Raue U, Hollon C, Minchev K, Trappe S. Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity. Am J Physiol Regul Integr Comp Physiol. 2008;295:R273-80. [PMID: 18448613] CrossrefMedlineGoogle Scholar5. Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, et al; Health ABC Study. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008;87:150-5. [PMID: 18175749] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Virginia Health System, Charlottesville, VA 22908.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults Ralf Nass , Suzan S. Pezzoli , Mary Clancy Oliveri , James T. Patrie , Frank E. Harrell Jr. , Jody L. Clasey , Steven B. Heymsfield , Mark A. Bach , Mary Lee Vance , and Michael O. Thorner Rejuvenation in Older Adults Receiving Oral Ghrelin Hernando Rafael Rejuvenation in Older Adults Receiving Oral Ghrelin Markus Gaugg Rejuvenation in Older Adults Receiving Oral Ghrelin Jim Webster Metrics 5 May 2009Volume 150, Issue 9Page: 655KeywordsAgingElderlyExerciseGhrelinGrowth hormoneInsulin-like growth factorsMammographyMusclesProteinsStrength training ePublished: 5 May 2009 Issue Published: 5 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...