tbuckley/cabot-search huggingface dataset:
SYNTHESIS OF PITUITARY HORMONES
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Masthead: (Adv. Healthcare Mater. 13/2018)
Journal: Advanced Healthcare Materials (2018)

Citizenship: Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those in need, enhancing community philanthropy, reducing our carbon impact, creating global guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our efforts.
Contributions to the Medical Sciences in Honor of Dr. Emanuel Libman by His Pupils, Friends and Colleagues.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
深度学习超越皮肤科医生
Authors: Y. Fujisawa, Y. Otomo, Y. Ogata, Y. Nakamura, R. Fujita, Y. Ishitsuka, R. Watanabe, N. Okiyama, K. Ohara, M. Fujimoto
Journal: British Journal of Dermatology (2019)

皮肤癌在全球范围内呈增长态势。然而,不论何时,让所有出现皮肤症状的患者都去皮肤科就诊总是不现实的。人工智能在皮肤癌的辅助筛查和诊断领域前景光明。虽然现已面世的几种计算机辅助分类系统能够以高灵敏度检出黑色素瘤,但这种高灵敏度是以降低特异度作为代价而实现的。灵敏度衡量正确识别的“真阳性”的比例(即:被正确识别为患有相应疾病的病人百分比)。特异度衡量正确识别的“真阴性”的比例(即:被正确识别为没有患有相应疾病的健康人百分比)。将一种名为深度卷积神经网络 (Deep convolutional neural network, DCNN) 的机器学习新方法应用于皮肤癌分类系统有望同时提高皮肤癌筛查的灵敏度和特异度。然而,目前认为这类系统所需的训练图像数量非常大,为罕见皮肤病编辑一个大型数据集比较困难。在本研究中,我们使用不足 5000 幅图像训练了 DCNN,并开发出一种可对 14 种不同皮肤肿瘤和相关疾病进行分类的 DCNN 分类系统。13 名经委员会认证的皮肤科医生对其性能进行了测试。结果表明,我们的系统仅需使用一幅图像,皮肤癌检测的灵敏度达到 96.3%、特异度达到 89.5%。DCNN 对恶性和良性肿瘤的分类准确度分别为 85.3% 和 92.4%,在统计学意义上高于经委员会认证的皮肤科医生。综上所述,我们使用相对较少的图像完成了对 DCNN 的训练,并由此开发出一种高效皮肤肿瘤分类系统。当前系统有望在一般医疗实践中用于筛查目的,但首先,它需要在临床试验中接受全面测试。
Asthma exacerbation in children immediately following stressful life events
Journal: Thorax (2005)

Surgery in early NSCLC and comorbidityWe would like to congratulate Janssen-Heijnen et al 1 on their well performed study and on their significant contribution to resolving the problem of treatment in patients with non-small cell lung cancer (NSCLC) and co-morbidity.However, we could not find a description of the surgical approach used and would like to ask the authors to provide details of the surgical procedures adopted and the accompanying survival rates.We think, 2 in agreement with other authors 3 that, for patients with early stage NSCLC and co-morbidity, a less invasive surgical approach should be used.This view is supported by studies in elderly patients or in patients with co-morbidity showing that a less invasive approach does not influence survival rates.Only the recurrence rate seems to be increased by a less invasive surgical approach such as segmentectomy or pulmonary wedge resection. [3]][5] Several factors determine whether conservative or invasive resection should be used for NSCLC.We think that a less invasive approach should be chosen as the first therapeutic step, even for early stage NSCLC, and that elderly patients should be treated less aggressively than younger patients.
European Perspectives
Authors: Marja-Riitta Taskinen, Gabriela Kania, Elena Osto, Markku Laakso, Francis Collins, Michael Boehnke, Ann Arbor, Päivi Pajukanta, Jake Lusis, Karen Mohlke
Journal: Circulation (2012)

Professor Taskinen received the Grand Prize of €20 000 in 2011.She has contributed to ≈500 peer-reviewed articles and provided novel, cutting-edge discoveries concerning diabetic dyslipidaemia, insulin resistance, and nonalcoholic fatty liver disease.Her group recently showed that dual metabolic defects are required to produce hypertriglyceridemia in centrally obese subjects. 1Professor Taskinen comments, "This landmark article elucidates the role of liver fat content as the driving force for the overproduction of large, very low-density lipoprotein particles and the role of apolipoprotein CIII as the regulator of the removal capacity of triglyceride-rich lipoproteins."Professor Taskinen has been instrumental in organising the Fenofibrate Intervention and Event Lowering study that has provided novel data with respect to lipoproteins as cardiovascular disease risk factors.The group also reported that a replacement of traditional lipid measures by apolipoprotein B or apolipoprotein A-I provided no extra benefits in predicting cardiovascular disease risk in type 2 diabetes mellitus.Recently, Professor Taskinen's team reported that incretin-based therapies improve postprandial lipaemia in people with diabetes mellitus. 2She says, "This discovery opens a new position for incretin-based therapies in diabetes care."A series of articles by the group has elucidated the predictive values of lipid abnormalities as predictors of kidney disease and cardiovascular disease in type 1 diabetes mellitus.In addition, Professor Taskinen has contributed to understanding the metabolic and genetic defects in familial combined hyperlipidaemia and low high-density lipoprotein.The upstream transcription factor 1 gene on 1q21 was discovered to be a potential familial combined hyperlipidaemia gene regulating both glucose and lipid metabolism.Extensive phenotyping and genotyping of Finnish low high-density lipoprotein family members has helped to identify sequence variants for genotype effects.The metabolic studies identified major compositional differences in highdensity lipoprotein subspecies and function in members of low high-density lipoprotein families.The lipidomics of high-density lipoprotein subclasses demonstrated extensive and significant compositional changes that also have functional consequences.
Sciatica
Authors: Susan Moon
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correspondence
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemotherapy for aquarium granuloma
Authors: J. J. Van Dyke
Journal: JAMA (1975)

<i>MYCOBACTERIUM BALNEI</i>, originally recognized as a pathogen to the abraded skin of swimmers in saltbrackish water and pools, has recently been found a hazard to fisherman and to those involved with fish tanks.<sup>1</sup>The following cases emphasize the hazard associated with aquariums and further substantiate the role of chemotherapy in the treatment of extensive<i>M balnei</i>infections. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 61-year-old white woman had abraded her fingers numerous times over the past 20 years while cleaning a home aquarium. In December 1971, a tender inflamed, indurated lesion developed on her right thumb, which was excised in March 1972. Progressive lesions developed on the right forearm (Figure). Some of these were excised and drained, and on pathological examination showed granulomas but no organisms. Sporotrichosis was suspected, but the lesions were unresponsive to iodides, and subsequently a carpal tunnel syndrome developed. Evaluation and culture performed elsewhere yielded<i>M</i>
Re-Carnation
Authors: David R. Scott
Journal: Annals of Internal Medicine (1995)

Ad Libitum1 February 1995Re-CarnationDavid R. Scott, MDDavid R. Scott, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-3-199502010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When we reach the winter of us allFrail FlowersEnd our uneasy seasonOn this sun-spotWhen we are ground—back to stardustGritty FlourBaked in the oven of foreverShall we all rise—spring again?Next time. Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1995Volume 122, Issue 3Page: 234KeywordsFlour ePublished: 15 August 2000 Issue Published: 1 February 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Computers
Authors: Clement J. McDonald
Journal: JAMA (1989)

Computer-based medical records promise to solve many of the access and legibility problems of the traditional paper chart. They can also influence the quality of care by calling attention to adverse trends and unattended medical problems reflected in the electronic chart. A small but increasing number of institutions are using such computer-based medical record systems and studying their effects on the efficiency and quality of care.<sup>1</sup>Computer systems do improve the availability of medical records—from 85% to 99% in one study.<sup>2</sup>However, they do not necessarily save patient and staff time. In the same study, the time spent in the clinic by patients who had computer-stored records increased by more than 5%, compared with the time spent by control patients, who had paper records.<sup>2</sup>This increase, however, may have been a side effect of a better quality of care. Patients in the study group had a greater
BOOKS REVIEWS
Authors: W. S. EL-DEIRY
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOKS REVIEWS Get access Introduction to the Cellular and Molecular Biology of Cancer, 2nd Edition L. M. Franks , N. M. TeichOxford : Oxford Univ. Press , 1992 . 558 pp., illus. $85 WAFIK S. EL-DEIRY WAFIK S. EL-DEIRY Johns Hopkins Oncology Center424 N. Bond St. Baltimore, MD 21231 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 12, 17 June 1992, Pages 976–977, https://doi.org/10.1093/jnci/84.12.976 Published: 17 June 1992
Reply
Authors: S. G Bown
Journal: Gut (1988)

Red eye and relapsing conjunctivitis-blepharitis are among the most common ocular disease in elderly patients. In these cases the search for causes is difficult and frustrating. We report the case of a 79-year-old woman with a long history of red eye and relapsing conjunctivitis-blepharitis caused by ocular rosacea. In this patient the proper diagnosis was performed after 10 years of ocular disease, and repeated evaluations by general practitioners and clinical specialists, only after the appearance of facial signs of erythematotelangiectatic rosacea. Adequate therapy with oral doxycycline led to the improvement of the clinical picture that previously had shown a poor response to several topical treatments. The possibility of ocular rosacea should be considered in evaluating an elderly patient with persistent red eye and relapsing conjunctivitis-blepharitis. Making the proper diagnosis is crucial because ocular rosacea does not respond as expected to topical therapy and may lead to severe corneal involvement.
Collective Investigation
Authors: T. M. Dolan
Journal: BMJ (1884)

1. To produce copious sweating to relieve the internal organs from congestion, especially the kidneys,I which were unable to eliminate morbid products from the blood.2. To check the excessive rise of temperature, and the dangers arising from it, as in typhoid fever, where the cold bath has been found to supersede the action of quinine, salicylate of soda, and all othler antipyretic remedies with which we are acquainted.When blood appeared in the urine after the pack had been used for some time, and the dropsy was fast disappearing, it was a signal proof that the kidneys were seriously involved.With all the precautions taken, this could in no degree be assigned to the packing.Not the
A College Textbook of Hygiene
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
REPORT OF THE MARYLAND TUBERCULOSIS COMMISSION.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acetaminophen-induced microvascular injury in the rat liver: Protection with misoprostol*1
Authors: S LIM
Journal: Hepatology (1995)

Studies into the mechanism of acetaminophen (APAP)-induced hepatotoxicity have focused mainly at the hepatocellular level. This study aimed to investigate the effect of acetaminophen on the hepatic microvasculature using a vascular casting technique. Acetaminophen was administered at a dose of 650 mg/kg body weight (intraperitoneally) to fasted male Long Evans rats. Microvascular casting was performed at various points after drug administration. Liver casts from control rats showed good patency with normal hepatic microvasculature. Thirty-six hours after overdose with acetaminophen, liver casts showed rounded centrilobular cavities of various sizes, representing regions in which cast-filled sinusoids were absent with relatively normal microvasculature within periportal regions. Evidence of microvascular injury occurred as early as 5 hours after acetaminophen overdose. This injury consisted of changes to centrilobular sinusoids including areas of incomplete filling and dilated centrilobular sinusoids. Misoprostol (a prostaglandin E1 analog) treatment (6 × 25 μg/kg) given before and after acetaminophen administration markedly reduced the extent of microvascular injury with only small focal unfilled areas in the casts and a generally intact microvasculature. In conclusion, this study shows that overdosage with APAP resulted in an extensive, characteristic pattern of hepatic microvascular injury in the centrilobular region. The results also suggest that microvascular injury is an early event in the pathogenesis of acetaminophen hepatotoxicity. Misoprostol was found to protect against injury occurring at the microvascular level.
American Journal of Anatomy, Philadelphia
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatology Highlights
Authors: Norihiro Imai, Tibor I. Krisko, Zaid H. Tafesh, Catherine Lucero, Michele Alves‐Bezerra, Hayley T. Nicholls, Sandra Steensels, Baran A. Ersoy, Russell Rosenblatt, Robert E. Schwartz, Vikas Gupta, Zurabi Lominadze, Brett E. Fortune
Journal: Hepatology (2018)

Imai, Norihiro; Krisko, Tibor I.; Tafesh, Zaid H.; Lucero, Catherine; Alves‐Bezerra, Michele; Nicholls, Hayley T.; Steensels, Sandra; Ersoy, Baran A.; Rosenblatt, Russell; Schwartz, Robert E.; Gupta, Vikas; Lominadze, Zurabi; Fortune, Brett E.Editor(s): Brown, Robert S. Jr. Author Information
Intestinal Disease and the Urban Environment
Authors: Harold P. Schedl
Journal: Environmental Health Perspectives (1979)

Factors in the urban environments of highly industralized societies are important causes of disease. This review examines urban diseases of small and large intestine. The urban environment is pervaded by chemicals including drugs, food additives, pesticides, industrial products, etc., which are potential causes of disease. Examples of typical urban, as contrasted with rural, intestinal disease are considered in terms of differing etiological factors. Urban intestinal disease is examined from the following standpoints: the population at risk; the chemical agents to which the population is exposed; a model for the physiology of distribution and metabolism of chemicals in relation to the alimentary tract; the application of this model to treatment of an industrial disease; a major urban disease of the alimentary tract, carcinoma of the colon, considered in terms of this model; approaches to characterizing, identifying, and controlling urban intestinal disease.