tbuckley/cabot-search huggingface dataset:
The effect of transendocardial delivery of autologous bone marrow stimulated by granulocyte monocyte colony stimulating factor (GM-CSF) on ischemic myocardial perfusion and function Shmuel Fuchs, Richard Baffour, Matie Shou, Yi Fu Zhou, Fermin O. Tio, Martin B. Leon, Stephen E. Epstein, Ran Kornowski. Cardiovascular Research Institute, Washington Hospital Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
Official Call to the Officers and Members of the American Medical Association to Attend the Annual Meeting of the House of Delegates in Chicago, June 16 Through 20, 1985
Authors: Joseph F. Boyle
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IRREGULAR HOURS AND SMALL PAY.
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drunken Driving
Authors: Sheila B. Blume
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I would like to comment on your otherwise excellent editorial concerning driving under the influence of alcohol and drugs<sup>1</sup>in which you comment that, in regard to drinking drivers who are alcoholic, "Only tough laws and tough enforcement are likely to help." I would remind our profession that alcoholism is a treatable disease and that recovered alcoholics do not drink and drive. A recent large-scale study (The National Institute of Mental Health Multisite Epidemiological Catchment Area Program)<sup>2</sup>found that alcoholism is the most common adult mental disorder in the United States, with a lifetime prevalence of 11% to 16%<sup>3</sup>and a six-month prevalence of 4.5% to 5.7%<sup>4</sup>in the three sites reporting. Thus, alcoholic drivers are not uncommon on our highways. Law enforcement agencies can create effective motivation, in alcoholics convicted of driving while impaired or intoxicated, to initiate and to continue the
Nano‐Graphene Oxide: A Potential Multifunctional Platform for Cancer Therapy
Authors: Gil Gonçalves, Mercedes Vila, María‐Teresa Portolés, María Vallet‐Regi, José Gracio, Paula Alexandrina A. P. Marques
Journal: Advanced Healthcare Materials (2014)

Adv. Healthcare Mater. 2013, 2, 1072–1090 The authors would like to add the following Acknowledgements to the previously published article 10.1002/adhm.201400329: The authors thank Fundação para a Ciência e a Tecnologia (FCT, Portugal), the European Union, QREN, FEDER, COMPETE, for funding the TEMA research unit (PEst-C/EME/UI0481/2013). G.G. thanks the FCT for a PostDoc grant (SFRH/BDP/84419/2012). M.V. and P.M. thanks the FCT Investigator Program, respectively the editions of 2012 and 2013.
Abstract 2009: ALX-0081 a Novel Anti-Thrombotic: Results of a Single-Dose Phase 1 Study in Healthy Volunteers and Further Development in Patients with Stable Angina Undergoing PCI
Authors: Jozef Bartunek, Emanuele Barbato, Josefin-Beate Holz, Kristof Vercruysse, Hans Ulrichts, NV Ablynx, Guy Heyndrickx
Journal: Circulation (2008)

Background : ALX-0081 is a bivalent Nanobody ® based on the variable domain of naturally occurring heavy-chain only antibodies. It binds with high affinity to the A1 domain of von Willebrand Factor (vWF) and thereby blocks the interactions between platelets and vascular collagen. It selectively prevents thrombus formation under high shear stress conditions. Aim : Test ALX-0081 single IV infusions (60 minutes) dosed from 0.5mg to 12mg total in 40 male healthy volunteers in double-blind, randomized, placebo controlled study and assess pharmacokinetic (PK), pharmacodynamic (PD), safety and immunogenicity. Results : ALX-0081 displayed non-linear pharmacokinetic properties, following a 2 compartment model. Ristocetin induced platelet aggregation (RIPA) was analyzed as marker for PD effect with full inhibition (defined as measured levels dropping &lt;10%) observed at ALX-0081 concentrations of ~ 400ng/ml. All subjects dosed ≥ 2mg achieved full RIPA inhibition at 1h post-dosing for maximum of 12h. ALX-0081 treatment was well tolerated and safe, no signs of bleeding were reported and no immunogenic response was detected. Target related mild and transient reductions of vWF and FVIII plasma levels were observed and all events were fully reversible. Phase Ib study design : double-blind, randomized, placebo controlled, multiple ascending dose study. ALX-0081 added to standard anti-thrombotic regimen (ASA, clopidogrel, UFH) in patients with stable angina undergoing elective PCI. Single-dose escalation will be followed by multiple dosing (up to 4 doses in 24h). Dose escalation will be guided by safety and efficacy marker. Endpoints: safety, pharmacological profile, biomarker (RIPA, RICO and ACT) and early clinical outcome (MACE, IMR, molecular marker). Conclusion : ALX-0081 can be administered safely over a wide range of dose-regimen. First results of the phase Ib study in stable angina patients will be presented.
Erratum: Vol. 65, No. 36
Authors: Alycia Mcnutt, David Santoro, Christina Nishimura, Diane Noel, Katherine Kelley
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Final 2015-16 influenza season vaccination coverage estimates are available online at FluVaxView (http://www.cdc.gov/flu/fluvaxview/).The online information includes estimates of the cumulative percentage of persons vaccinated through the end of each month during July 2015-May 2016, for selected local areas, states, and regions as designated by the U.S. Department of Health and Human Services, and the
Physician Certification and Implantable Cardioverter-Defibrillators
Authors: Jeff Whittle
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Statistics
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In This Issue/Research Watch/News-in-Brief/News from the IASLC Tobacco Control Committee
Journal: Journal of Thoracic Oncology (2017)

The authors reported the outcome of a study of singlefraction carbon ion radiotherapy for patients with stage I NSCLC (n¼ 218), of which 61.5% were medically inoperable.There were 123 stage T1 tumors and 95 stage T2 tumors; 146 adenocarcinomas, 68 squamous cell carcinomas, three large cell carcinomas, and one mucoepidermoid carcinoma.The total dose was increased from 28 to 50 Gy.After a median follow-up of 57.8 months, the overall survival rate at 5 years was 49.4%, and local control (LC) rate was 72.7%.LC rate was significantly different between those treated with 36 Gy and those treated with <36 Gy.Twenty patients treated with 48-50 Gy achieved an LC rate at 5 years of 95.0%, an overall survival rate of 69.2%, and the progression-free survival rate of 60.0%.No grade 3 or higher adverse lung and skin reactions were observed while only one grade 3 chest wall pain was found.To summarize, single-fraction carbon ion radiotherapy could improve patient outcomes compared with previous fractionated regimens.(p.673)
STUDIES ON THE EFFECT OF LIGHT ON VITILIGO.*
Authors: CARL WITH
Journal: British Journal of Dermatology (1920)

WHILE working at light-baths in the Finsen Institute I clearly perceived that there was a problem of uncommon interest as to the relation of vitiligo to light.On December 4-th, 1918, I demonstrated to the Danish Society of Dermatology t a patient suffering from a decided macular pigmentation produced by light-baths.To this demonstration I added some general views regarding the effect of light on vitiligo.It was my intention at that time to discuss the question on a broader basis, and I wanted especially to examine the pigniented spots by the dopa-reaction.However, Dr. Kissmeyer returned home from Bruno Bloch in Zurich with a supply of dopa,
AUTHOR'S REPLY
Authors: H S Markus, J V Clark
Journal: Thorax (1990)

<h3>ABSTRACT</h3> The few established causal genes in Alzheimer’s disease (AD), mutations in <i>APP</i> and <i>PSENs,</i> have been functionally characterized using biomarkers, capturing an <i>in vivo</i> profile reflecting the disease’s initial preclinical phase. <i>SORL1</i>, a gene encoding the endosome recycling receptor SORLA, epidemiologically behaves as a causal gene when truncating mutations lead to partial loss of protein function. Here, in an effort to test whether <i>SORL1</i> can indeed function as an AD causal gene, we used CRISPR-Cas9-based gene editing to develop a novel model of <i>SORL1</i> haploinsufficiency in Göttingen Minipigs taking advantage of porcine models for biomarker investigations. <i>SORL1</i> haploinsufficiency in young minipigs was found to phenocopy the preclinical <i>in vivo</i> profile of AD observed with other causal genes, resulting in spinal fluid abnormalities in Aβ and tau, with no evident neurodegeneration or amyloid plaque formation. These studies provide functional support that <i>SORL1</i> is a bona fide causal gene in AD, and when taken together with recent insight on other AD-causal genes, support the idea that dysfunctional endosomal recycling is a dominant pathogenic pathway in the disease.
Autoantibodies tied to some heart ailments
Authors: C. A. Raymond
Journal: JAMA (1986)

In 1967, pediatrician Jacqueline A. Noonan, MD, saw a baby in the hospital nursery with congenital heart block. Looking outside the nursery door, she noted a mother with a large butterfly rash on her face. Noonan turned to a maternity ward nurse and asked: "Does that mother go with that baby?" Told that she did, Noonan remarked that the mother had lupus. The nurse replied that the mother had undergone a test for lupus erythematosus (LE) cell factor (a type of antinuclear antibody often present in lupus patients' serum), the results of which were negative. Recalling everything she knew from, training and experience about the signs of this disorder, Noonan exclaimed: "I can't help that, she's got lupus!" Ninety percent of deaths from congenital heart disease occur within the first year of life, but pediatricians are at a loss to understand what causes most of the heart defects they encounter.
Mapping, cloning and genetic characterization of the region containing the Wilson disease gene Petrukhin K, Fischer SG, Pirastu M, Tanzi RE, Chernov I, Devoto M, Brzustowicz LM, Cayanis E, Vitale E, Russo J, Matseoane D, Boukhgalter B, Cao A, Sternlieb I, Evgrafov O, Parano E, Pavone L, Warburton D, Ott J, Penchaszodeh GK, Scheinberg IH, Gilliam TC. Nature Genet 1993;5:338–343
Journal: Hepatology (1994)
Pseudotumor cerebri secondary to lithium carbonate
Authors: R. F. Saul
Journal: JAMA (1985)

Three patients were initially seen with headache, blurred vision, and papilledema while taking lithium carbonate for their respective bipolar affective disorder. A diagnosis of pseudotumor cerebri was made in each case when a thorough evaluation revealed only elevated intracranial pressure. Two of the patients had complete resolution of their symptoms and papilledema after discontinuing use of the drug. Increased intracranial pressure with papilledema persisted in the third patient when she failed to adjust psychiatrically, necessitating continuance of the lithium carbonate therapy. A history of lithium carbonate ingestion should be sought in patients with the syndrome of pseudotumor cerebri. All patients receiving this drug should have a regular funduscopic examination. (<i>JAMA</i>1985;253:2869-2870)
CANCER CLINIC: Carcinoma of the Large Bowel and Rectum
Journal: CA A Cancer Journal for Clinicians (1959)

The Vicksburg Hospital, a small non university institution, admits about 4000 predominantly surgical patients annually.The hospital is staffed by the Vicksburg Clinic.There are approximately 40,000 outpatient consultations per year.In 1957 4100 tissue specimens were examined in the Laboratories of Pathology, from all sources and of these, 313 were found to be cancer.For many years this hospital has con ducted an approved Tumor Clinic, which meets weekly.At this time, patients hav ing, or suspected of having, malignant dis ease as well as follow-up patients are pre sented.The Tumor Clinic staff consists of two general surgeons, one internist, one FrommmTime Tummmor Climmic, Time Picksburg Hospital, I'ick.sliurg,Mississippi.
The physician as communicator
Authors: N. Cousins
Journal: JAMA (1982)

FOUR YEARS ago, I accepted an invitation to teach literature and philosophy to medical students and to study problems in patient-physician relationships from the standpoint of patients. I also wanted to pursue research in a field of deep interest to me, the biochemistry of the emotions. I thought I would have to brace myself for all the shocks that go with a new career, but I quickly discovered that physicians and writers have at least one thing in common: communication is an important part of their trade. In journalism, you live or die by your ability to use words. In health care, the words used by the physician have a profound effect on the well-being of the patient. Words used by the physician can be gate-openers or gate-slammers. They can open the way to recovery, or they can make a patient dependent, tremulous, fearful, or resistant. The right words can
Three-year outcomes of a phase II study of adjuvant chemotherapy with S-1 plus docetaxel for stage III gastric cancer after curative D2 gastrectomy (OGSG1002)
Authors: Ryohei Kawabata, Kazumasa Fujitani, Shigeyuki Tamura, Yutaka Kimura, Hiroshi Imamura, Junya Fujita, Jin Matsuyama, Shohei Iijima, Shugo Ueda, Yukinori Kurokawa, Daisuke Sakai, Toshio Shimokawa, Toshimasa Tsujinaka, Hiroshi Furukawa, Taroh Satoh
Journal: Annals of Oncology (2017)
Investigation of the nine most commonly used resuscitator bags
Authors: E. Carden
Journal: JAMA (1970)

Nine commonly used resuscitator bags were connected to an oxygen source, and tested by manually squeezing an 800-cc tidal volume ten times per minute into a test apparatus which measured the oxygen concentration delivered (up to 15 liters of oxygen per minute flowing). They were then tested on conscious volunteers. The Ambu gave the highest oxygen concentration (87% maximum) and the Pulmonator, the lowest (37% maximum). The Ambu with the new E-2 valve was found to be superior in function to the Ambu (with the Ruben valve) and the Ambu (Air Shields). The most common malfunction was sticking of the inflating valve in the inspiratory position. This was found with the Laerdal, Pulmonator, and Ambu (Ruben valve). The Ambu (with E-2 valve) was the easiest to use; the Pulmonator, Aga, and Laerdal (with reservoir), the most clumsy.
BOOK REVIEW
Authors: J. H. EDMONSON
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article BOOK REVIEW Get access Cancer of the Ovary . Maurie Markman , William J. Hoskins , eds. New York : Raven Press , 1993 . 458 pp., illus. $ 125. ISBN 0-88167-970-4 JOHN H. EDMONSON, M.D. JOHN H. EDMONSON, M.D. Mayo Clinic, Division of Medical Oncology, 200 First St.,S.W. Rochester, MN 55905 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 15, 4 August 1993, Page 1246, https://doi.org/10.1093/jnci/85.15.1246 Published: 04 August 1993
Correction
Journal: Annals of the Rheumatic Diseases (2011)

Background Indocyanine green (ICG)-enhanced fl uorescence optical imaging (FOI) is an established technology for imaging of infl ammation in animal models.In experimental models of arthritis, FOI fi ndings corresponded to histologically proven synovitis.This is the fi rst comparative study of FOI with other imaging modalities in humans with arthritis.Methods 252 FOI examinations (Xiralite system, mivenion GmbH, Berlin, Germany; ICG bolus of 0.1 mg/kg/ body weight, sequence of 360 images, one image per second) were compared with clinical examination (CE), ultrasonography (US) and MRI of patients with arthritis of the hands.Results In an FOI sequence, three phases could be distinguished (P1-P3).With MRI as reference, FOI had a sensitivity of 76% and a specifi city of 54%, while the specifi city of phase 1 was 94%.FOI had agreement rates up to 88% versus CE, 64% versus greyscale US, 88% versus power Doppler US and 83% versus MRI, depending on the compared phase and parameter.FOI showed a higher rate of positive results compared to CE, US and MRI.In individual patients, FOI correlated signifi cantly (p<0.05) with disease activity (Disease Activity Score 28, r=0.41),US (r=0.40) and RAMRIS (Rheumatoid Arthritis MRI Score) (r=0.56).FOI was normal in 97.8% of joints of controls.Conclusion ICG-enhanced FOI is a new technology offering sensitive imaging detection of infl ammatory changes in subjects with arthritis.FOI was more sensitive than CE and had good agreement with CE, US in power Doppler mode and MRI, while showing more positive results than these.An adequate interpretation of an FOI sequence requires a separate evaluation of all phases.For the detection of synovitis and tenosynovitis, FOI appears to be as informative as 1.5 T MRI and US.
It doesn't always require a medical degree to report medicine's story to the public
Authors: C. Marwick
Journal: JAMA (1987)

IT IS OFTEN said that the practice of medicine is like a detective story. The patient presents clues to be followed, some leading nowhere, others eventually proving crucial. Arthur Conan Doyle, MD, considered by many mystery fans to be the father of the detective story, is held to have based the character of Sherlock Holmes on one of his teachers at the University of Edinburgh. It is surely appropriate therefore that Berton Roueché, one of the best-known reporters of the world of medicine, should have received an award from the Mystery Writers of America for one of his articles describing an unusual series of cases of sodium nitrite poisoning among some New York bowery derelicts. Titled, with Holmesian echoes, "The Case of the Eleven Blue Men," the article appeared in 1947 in<i>The New Yorker</i>magazine, the publication for which Roueché has worked for more than 40 years. The award
OSTEOMYELITIS OF THE PELVIC BONES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal