tbuckley/cabot-search huggingface dataset:
Abstract 16621: Clinical Results of Scar Related Ventricular Tachycardia Ablation Performed in a South America School Hospital
Authors: Cristiano Pisani, Carina Hardy, Sissy Lara, Muhieddine Chokr, Hugo Bellotti, Denise Hachul, Francisco Darrieux, Eduardo Sosa, Mauricio Scanavacca
Journal: Circulation (2015)

Introduction: Ventricular Tachycardia (VT) ablation is indicated in patients with recurrent episodes of VT or ICD shocks despite the use of AAD. Hypothesis: to evaluate the clinical characteristics and follow-up of patients that underwent scar related VT ablation in a school hospital in south america. Methods: We collected and analyzed data of all VT ablation performed in our institution between 2013 and 2014. Results: During the 2-year period we performed 107 scar related VT ablation procedures in 86 patients with an age of 56.7±14 years-old, most were male (70,9%). Sixty (56%) presented Chagas disease, 17 (16%) ischemic, 13 (12%) dilated, 12 (11%) RVAD and 5 (5%) other cardiomyopathies and the mean LV EF was 36.9±12.4%. The ablation was performed with CARTO in 60 (56,1%), Ensite 3 (2,8%) and EP only mapping in 44 (41,1%) procedures. Epicardial mapping was performed in 65 procedures (60,7%), most frequent in Chagas patients (81,7%;P&lt;0.001). There was complications in 6 (5,6%) procedures: one hemopericardium that open-chest surgery was necessary; two iliac artery dissection, both with conservative treatment; one complete AV block; one patient with refractory hypotension with the need of IABP and procedure interruption and one patient with late cardiac tamponade with the need of surgical drainage. In a median follow-up of 261 (Q1: 93 Q3: 479) days, 42 (40%) procedures presented recurrence in a median time of 40 (Q1: 7.5 Q3: 125) days. After the VT recurrence the ablation was repeated, and one patient underwent 4 ablation, 2 three ablations and 13 underwent two ablations. Following the last ablation, 61 (72.6%) patients remained free of VT recurrence (figure). Sixteen (19%) patients died in a median time of 34 (Q1: 14.75 Q3: 93) days following last ablation. Conclusion: Chagas disease was the most common cardiopathy in this population, where epicardial approach was frequently performed. After the last procedure, the majority of patients remained free of VT recurrence
Unusual infections caused by Pasteurella multocida
Authors: R. H. Johnson
Journal: JAMA (1977)

Three cases of infection with Pasteurella multocida included acute epiglottitis, septic arthritis, and pleuropulmonary infection. Human infections with this microorganism are commonly related either to animal contact (eg, wound infections) or to the presence of underlying chronic respiratory tract disease. Although septic arthritis and pleuropulmonary infections have previously been attributed to this pathogen, to our knowledge, this is the first reported case of acute epiglottitis caused by<i>P</i>multocida. (<i>JAMA</i>237:146-147, 1977)
'Deradiating' the former uranium capital
Authors: B. Merz
Journal: JAMA (1987)

THE URANIUM ATOM that once hovered over a mountaintop has disappeared from the seal of the city of Grand Junction, Colo. In its place is a setting sun. The substitution is telling. The city that once proclaimed itself "The Uranium Capital of America" is in the process of divorcing itself from the radioactive element—literally as well as symbolically. The last vestiges of uranium are being shoveled from the community. The removal is part of the federal Department of Energy's (DOE) Remedial Action Program. It was established in 1972 to clean up areas of the country in which radiation exposure in excess of normal background levels could be attributed to wastes from DOE-operated uranium processing plants. Grand Junction was the first area to qualify. A good portion of the city is built on radioactive tailings—by-products of a uranium-processing industry. The tailings emit small amounts of radon—one of the radioactive decay products
FUNCTIONAL ALBUMINURIA
Authors: ROBERT STERLING PALMER
Journal: JAMA (1931)

Functional, orthostatic, postural or transient albuminuria is not an uncommon finding. Most observers of large series report an incidence of 5 per cent,<sup>1</sup>although as high as 9.9 per cent<sup>2</sup>and even 16 per cent<sup>3</sup>have been found. Calvin, Isaacs and Meyer<sup>4</sup>have studied the subject in children. They found it more commonly among children who received poor care than among those who had excellent care, 60 per cent in the former, 15 per cent in the latter. They classified their cases as follows: (<i>a</i>) malnutrition albuminuria, usually associated with anemia, a possible cause being focal infection: (<i>b</i>) orthostatic or postural albuminuria, and (<i>c</i>) idiopathic or "growth" albuminuria, including under this head the so-called juvenile, pubertal, cyclic, transitory or intermittent albuminurias. Fishberg<sup>5</sup>has reviewed the literature on the "benign" albuminurias, noting the early observations of Becquerel in 1841, Vogel in 1864 and Sir William Gull
Blood and ascites pharmacokinetics of meropenem in patients with nosocomial spontaneous bacterial peritonitis and decompensated liver cirrhosis
Authors: Marie Schultalbers, Denis Grote-Koska, Thorsten Book, Birgit Bremer, Korbinian Brand, Michael P. Manns, Markus Cornberg, Julius J. Schmidt, Benjamin Maasoumy
Journal: Journal of Hepatology (2020)
Intrapleural tetracycline for spontaneous pneumothorax
Authors: R. C. Goldszer
Journal: JAMA (1979)

SPONTANEOUS pneumothorax may be treated by observation, needle aspiration, intercostal drainage, chemical pleurodesis, and surgical pleurodesis. Persistent air leak (longer than five to seven days) or recurrent pneumothoraxes are considered indications for thoracotomy and surgical repair, with or without pleurodesis. The risk of surgical treatment increases with increasing age and the presence of underlying disease. In this group, chemical pleurodesis may avoid the risk of surgery. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 57-year-old man was admitted with increasing dyspnea and pleuritic pain for two days. The past medical history and a review of systems were unremarkable. He smoked two packs of cigarettes per day for the past ten years. Physical examination findings showed the patient to be in mild respiratory distress. The respiratory rate was 22/min, the blood pressure (BP) was 130/80 mm Hg, the heart rate was 86 beats per minute, and the temperature was 37 °C. There was
"Typical" and "Atypical" Serum Insulin-Like Activity in Untreated Diabetes Mellitus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delay in diagnosis of mild hemophilia A
Authors: C. L. Beall
Journal: JAMA (1974)

THE overt signs and symptoms of classical severe hemophilia usually lead to detection in childhood, whereas milder forms of the disease may elude documentation until catastrophic postoperative bleeding occurs in late adolescence.<sup>1</sup>The delay in diagnosis is due, in part, to a lack of understanding of the natural history of mild hemophilia. Often, these patients will remain virtually free from spontaneous bleeding manifestations as well as hemorrhage following significant surgical or traumatic provocation. The diagnosis can almost always be established if the activated partial thromboplastin time (aPTT) is employed as one of the routine preoperative tests to screen for disorders of hemostasis. The following case report illustrates these points as well as some additional atypical features of mild hemophilia A. <h3>Report of a Case</h3> A 29-year-old white male computer technician was transferred to the Washington Hospital Center because of excessive bleeding for 24 hours following a ureterolithotomy. One year
Somalia's death toll underlines challenges of post-cold war world
Authors: A. Flanagin
Journal: JAMA (1992)

MORE THAN 1000 people died from starvation and disease each day in Somalia on the east-coast Horn of Africa during the past month. Experts predict that as many as one third of the faminestricken, wartorn country's 6 million people may die before the end of the year. How in this post-Cold War era of global détente and technological abililites could the international community have allowed this situation to become so dire? Why has this famine, the fourth of such drought-caused disasters to strike Somalia since 1979, taken such a devastating toll? Why weren't the early warning signals of impending famine, which began surfacing more than a year ago, noticed? And if they were known, why were governmental, international, and public responses muted until only recently? The answers to these and many related questions were debated during a symposium on health, human rights, and humanitarian assistance in conflicts and disasters, cosponsored
Response to Letter Regarding Article, “Triple Versus Dual Antiplatelet Therapy in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention”
Authors: Seung-Woon Rha, Kang-Yin Chen, Yong-Jian Li, Kanhaiya L. Poddar, Zhe Jin, Yoshiyasu Minami, Lin Wang, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Myung Ho Jeong, Young Keun Ahn, Taek Jong Hong, Young Jo Kim, Seung Ho Hur, In Whan Seong, Jei Keon Chae, Myeong Chan Cho, Jang Ho Bae, Dong Hoon Choi, Yang Soo Jang, In Ho Chae, Chong Jin Kim, Jung Han Yoon, Wook Sung Chung, Ki Bae Seung, Seung Jung Park
Journal: Circulation (2010)
Helicobacter pylori, gastroduodenal disease, and recurrent abdominal pain in children
Authors: C. Macarthur
Journal: JAMA (1995)

<h3>Objective.</h3> —To assess the evidence for a cause-and-effect relationship between<i>Helicobacter pylori</i>infection and antral gastritis, peptic ulcer disease, and recurrent abdominal pain in children. <h3>Data Sources.</h3> —A MEDLINE search from January 1983 through July 1994 was used to identify pertinent English-language publications.<i>Current Contents</i>and selected specialty journals were searched manually. Editorials, reviews, case reports, abstracts, and letters to the editor were excluded. <h3>Study Selection.</h3> —All studies in children (ie, 0 to 18 years) were included. <h3>Data Extraction.</h3> —Hill's criteria for causal inference were used to determine the strength of the evidence for a causal relationship. <h3>Data Synthesis.</h3> —In total, 45 studies (case series, cross-sectional surveys, and treatment trials) were retrieved. The rate ratio of antral gastritis in children with<i>H pylori</i>infection (compared with uninfected children) ranged from 1.9 to 71.0 (median, 4.6). The prevalence of<i>H pylori</i>infection in children with duodenal ulcer was high (range, 33% to 100%; median, 92%) compared with children with gastric ulcer (range, 11% to 75%; median, 25%). Prevalence rates of infection in children with recurrent abdominal pain were inconsistent (range, 0% to 81%; median, 22%), with lower rates in children meeting Apley's criteria (range, 0% to 9%; median, 6%). <h3>Conclusions.</h3> —There is strong evidence for an association between<i>H pylori</i>infection and antral gastritis and duodenal ulcer disease in children; however, data from randomized, double-blind, placebo-controlled treatment trials are required. There is weak evidence for an association with gastric ulcer and weak or no evidence for an association with recurrent abdominal pain. (<i>JAMA</i>. 1995;273:729-734)
Selected Articles from This Issue
Journal: Clinical Cancer Research (2021)

Targeting mutant RAS in cancer has been a long sought-after goal. Previous work has suggested that, although ineffective in the KRAS-mutant setting, MEK inhibition may be an appropriate strategy for NRAS-mutant tumors. As part of the Phase II NCI-MATCH trial, Cleary and colleagues assessed the efficacy of binimetinib, a MEK inhibitor, in patients with NRAS-mutated nonmelanoma cancers. Although the study did not meet its primary analysis with an observed ORR of 2.1%, subsequent analyses revealed improved responses in patients with codon 61 NRAS mutations compared with those with codon 12/13 mutations. Future trials will further elucidate the clinical benefit of MEK inhibition in patients with codon 61 NRAS mutations.Previous work had linked mTOR signaling to metastatic progression of high-grade osteosarcoma, and mTOR inhibition has been proposed as a treatment strategy. However, osteosarcoma's orphan disease status complicates clinical study of novel agents. LeBlanc and colleagues performed a clinical trial of the mTOR inhibitor sirolimus in pet dogs with treatment-naïve appendicular osteosarcoma. Although well-tolerated when added to standard-of-care treatment, sirolimus did not extend disease-free survival or overall survival. While disappointing, these results highlight the value of conducting clinical trials in pets with cancer, where the natural history of the disease more closely resembles that in humans than laboratory models.Immunotherapy has demonstrated limited clinical activity in refractory metastatic proficient mismatch repair (pMMR) CRC. Marie and colleagues performed a pilot clinical trial combining CTLA-4 inhibition (tremelimumab) with anti-PD-L1 inhibition (durvalumab) perioperatively in patients with resectable pMMR CRC liver metastasis. This combination led to an expected toxicity profile. Four patients demonstrated complete pathological response. Tissue analysis revealed treatment-induced activation of CD8+ and CD4+ T cells as well as increased B-cell density in responders. Further study of checkpoint inhibition in this patient population is warranted.Hypoxia is known to contribute to resistance to checkpoint inhibitors. Hegde and colleagues performed a phase I study assessing the safety and efficacy of combining evofosfamide, a prodrug that reduces hypoxia, with ipilimumab in patients with cancer types typically refractory to immunotherapy. This combination was well tolerated and showed signs of efficacy, with an overall disease control rate of 83.3%. Further analysis of responders and nonresponders revealed a positive association between T-cell inflammation and response and a negative association between a baseline hypermetabolic phenotype and response. Further study of biomarkers or additional combined therapeutics is needed to maximize patient benefit from this strategy.
Why I Am a Vegetarian.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphedema tarda
Authors: J. Segal
Journal: JAMA (1976)

The clinical recognition and evaluation of congenital lymphedema of the lower extremities with abrupt onset in a 51-year-old man are reviewed. A rational, systematic approach is outlined and exemplifies the use of an interdisciplinary effort to achieve accurate diagnosis through readily available diagnostic procedures. (<i>JAMA</i>235:1996-1997, 1976)
Postcoital urticaria in a penicillin-sensitive patient. Possible seminal transfer of penicillin
Authors: R. L. Green
Journal: JAMA (1985)

PRACTICALLY all drugs are capable of causing allergic reactions, and all routes of exposure can be potentially sensitizing—although some are more so than others (ie, intravenous and intramuscular vs oral). A particularly vexing clinical situation arises when drug exposure occurs surreptitiously through some other medium. For example, penicillin used to be found in cow's milk when cows were treated for mastitis<sup>1</sup>; infants may contact a drug in their mother's colostrum when nursing<sup>2</sup>; and frozen foods can contain antibiotics.<sup>1</sup> We have recently treated a female patient who developed urticaria following sexual intercourse, and in whom we believe hives occurred because of allergy to a medication transmitted in her partner's semen. <h3>Report of a Case</h3> The patient was a healthy 33-year-old woman who was being treated in our office with immunotherapy to pollens, dust, and molds for her allergic rhinitis. She called one day to report that she had
Are "America's Best Hospitals" America's Best?
Authors: Avery Comarow
Journal: JAMA (1997)

<h3>To the Editor.</h3> —We echo and endorse Dr Green and colleagues'<sup>1</sup>call for nationally representative databases with which to assess quality of care at American hospitals and an augmentation of funding for the provision of such data. Absent funding of the necessary magnitude, however, and believing that health consumers still need help in framing discussions with their physicians about quality issues, we have been compelled to forge ahead using a combination of secondary data sources and primary data collected from physicians. Green et al agree that our conceptual framework is solid, but they question the choices made in operationalizing some of our subconstructs. We wish to point out that some of the supposed inadequacies noted by Green and colleagues were in fact remedied in the 1996 edition or will be changed in the 1997 version.<sup>2</sup>Specifically, we changed our incremental scoring method for the technology index, so that institutions are indeed
Revue de Médecine, Paris
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Veil
Authors: Lydia Kang
Journal: Annals of Internal Medicine (2006)

On Being a Doctor19 December 2006The VeilLydia Kang, MDLydia Kang, MDFrom Bellevue Hospital Center, New York, NY 10016.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-12-200612190-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail My latest palliative care consult lies in bed in front of me. He's a tall, dark-skinned Hispanic man—I almost want to call him a boy, because he's only 25 years old. He has the build of a basketball player who's been lying around for too long, muscles gone too soft for someone of his stature and age. He has no hair—chemo, of course. He wears a little gray fleece cap that covers his forehead so that I can barely see his eyes. The Ewing sarcoma has spread to his meninges and brain, and a third nerve palsy keeps one eye ... Author, Article, and Disclosure InformationAuthors: Lydia Kang, MDAffiliations: From Bellevue Hospital Center, New York, NY 10016.Corresponding Author: Lydia Kang, MD, Section of General Internal Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 993331 Nebraska Medical Center, Omaha, NE 68198-3331; e-mail, lydiakang1@yahoo.com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHow Should Careproviders Respond When the Medical System Leaves a Patient Short? 19 December 2006Volume 145, Issue 12 Page: 932 Keywords Brain Meninges Mouth Muscles Muscular dystrophies Nerves Palliative care Paralysis Sarcoma Sleep ePublished: 19 December 2006 Issue Published: 19 December 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Developmental Dyslexia
Authors: Robin L. Peterson, Bruce F. Pennington
Journal: Annual Review of Clinical Psychology (2015)

This review uses a levels-of-analysis framework to summarize the current understanding of developmental dyslexia's etiology, brain bases, neuropsychology, and social context. Dyslexia is caused by multiple genetic and environmental risk factors as well as their interplay. Several candidate genes have been identified in the past decade. At the brain level, dyslexia is associated with aberrant structure and function, particularly in left hemisphere reading/language networks. The neurocognitive influences on dyslexia are also multifactorial and involve phonological processing deficits as well as weaknesses in other oral language skills and processing speed. We address contextual issues such as how dyslexia manifests across languages and social classes as well as what treatments are best supported. Throughout the review, we highlight exciting new research that cuts across levels of analysis. Such work promises eventually to provide a comprehensive explanation of the disorder as well as its prevention and remediation.