tbuckley/cabot-search huggingface dataset:
Effects of Medicare and Title XIX on House-Staff Training Programs
Authors: W. Perkins
Journal: JAMA (1967)

The amended Social Security Act of 1965, or Public Law 89-97, includes Title XVIII, the Medicare bill; and Title XIX, the Medical Assistance Program. Title XVIII (Medicare) went into effect in all states on July 1, 1966. On the other hand, the effective date of Title XIX (the Medical Assistance Program) is an individual matter for each state legislature to decide sometime before 1975. To date, approximately 19 states, including California, have put Title XIX into effect. The Medical Assistance Program became effective in California on March 1, 1966, and thus California has had as much experience with both Titles XVIII and XIX as any other state. However early, it is not premature to report the effects of this legislation on intern-resident training programs, and to outline some of the problems which have resulted. It is assumed that the basic purposes and rules of Title XVIII are understood, but this
Self harm was misrepresented (again)
Journal: BMJ (2005)

This is an observational study and may be subject to residual confounding.However, we think that enough concerns exist to warrant a reconsideration of the cardiovascular safety of all NSAIDs.We thank the EMIS practices contributing to QRESEARCH database and David Stables (EMIS Computing) and Mike Pringle for their help and expertise in establishing QRESEARCH.
A PRIMER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Heart and ARTERIAL System, Designed to be a Practical Presentation of the Subject for the Use of Students and Practitioners of Medicine.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Development of Applied Action Levels for Soil Contact: A Scenario for the Exposure of Humans to Soil in a Residential Setting
Authors: Richard M. Sedman
Journal: Environmental Health Perspectives (1989)

The California Site Mitigation Decision Tree Manual, 1985, was developed by the California Department of Health Services to provide a detailed technical basis for managing uncontrolled hazardous waste sites. The Decision Tree describes a process that relies on criteria, Applied Action Levels (AALs) to evaluate and, if necessary, mitigate the impact of uncontrolled hazardous waste sites on the public health and the environment. AALs are developed for individual substances, species, and media of exposure. AALs have been routinely developed for the media of air and water; however, an approach for developing AALs for soil contact was lacking. Given that the air pathway for soil contact is addressed in AALs for air, two routes of exposure, ingestion and dermal contact, are addressed in developing AALs for soil contact. The approach assumes a lifetime of exposure to soil in a residential setting. Age-related changes in exposure are included in the scenario. Exposure to soil due to ingestion and dermal contact are quantitated independently and then integrated in the final exposure scenario. A mass balance approach using four elements is employed to quantitate soil ingestion for a young child. Changes in soil ingestion with age are based on age-related changes in blood lead concentration and mouthing behavior. Dermal exposure to soil was determined from studies that reported skin soil load and from estimates of exposed skin surface area. Age-related changes in the dermal exposure to soil are also based on changes with age of blood lead concentration and mouthing behavior. The estimates of exposure to soil due to ingestion and dermal contact are integrated, and an approach for developing AALs is advanced. AALs are derived by allocating the Maximum Exposure Level as described in the Decision Tree to the average daily exposure to soil. Toxicokinetic considerations for the two routes of exposure must be included in deriving AALs for the soil medium of exposure.
Prevalence of hidradenitis suppurativa among patients with Down syndrome: a population-based cross-sectional analysis
Authors: A. Garg, A. Strunk, M. Midura, V. Papagermanos, H. Pomerantz
Journal: British Journal of Dermatology (2018)

Hidradenitis suppurativa (HS) is a debilitating, chronic, painful inflammatory disease. Scientists have previously suggested that there is a potential genetic link predisposing Down syndrome patients to the development of HS through the increased formation of the amyloid precursor protein. However, this laboratory based finding had not previously been verified in the population. In this study, we evaluated the commonness of hidradenitis suppurativa within a large group of patients who had Down syndrome, and we used another groups of patients that did not have Down syndrome to compare findings. We observed that the diagnosis of hidradenitis suppurativa was present among 2.1% of patients with Down syndrome over the past five years. Compared to those without Down syndrome, patients with the condition had five times the likelihood of having hidradenitis suppurativa during the period of the study. Hidradenitis suppurativa was most common among Down syndrome patients who were aged 18–29 years. Hidradenitis suppurativa affected males and females, and whites and non‐whites, with Down syndrome equally. The diagnosis of hidradenitis suppurativa is made at a younger age among patients with Down syndrome, compared to patients without the condition. This suggests that hidradenitis may occur earlier in life among patients with Down syndrome, or it may occur more severely and thereby prompt earlier visits to the doctor for this condition. It is also possible that hidradenitis suppurativa is diagnosed earlier among patients with Down syndrome because doctors may be examining patients with Down syndrome more frequently in general.
Update: Mortality Attributable to HIV Infection/AIDS Among Persons Aged 25-44 Years— United States, 1990 and 1991
Journal: JAMA (1993)

During the 1980s, human immunodeficiency virus (HIV) infection emerged as a leading cause of death in the United States. This report updates national trends in deaths caused by HIV infection during 1990 and 1991 and indicates that HIV infection/acquired immunodeficiency syndrome (AIDS) continues to cause an increasing proportion of all deaths.
Putative Mechanisms of Toxicity of 3-Methylindole: From Free Radical to Pneumotoxicosis
Authors: T. Bray
Journal: The Annual Review of Pharmacology and Toxicology (1994)

Due to the massive data sets available for drug candidates, modern drug discovery has advanced to the big data era. Central to this shift is the development of artificial intelligence approaches to implementing innovative modeling based on the dynamic, ...Read More
Hepatic expression of ?-smooth muscle actin in chronic hepatitis C: Correlation with disease activity and changes with therapy 1Division of Gastroenterology and Hepatology, 2Dept. of Pathology, St. Louis University School of Medicine, St. Louis, MO
Journal: Hepatology (1995)

In the liver of humans, guinea pigs, cats, and tupaia, nerve endings are distributed all over the hepatic lobules from the portal spaces to the centralobular spaces. Nerve endings in the intralobular spaces are located mainly in the space of Disse, and are closely related to lipocytes. In the human liver, various neurotransmitters such as substance P (SP) exist in the nerve endings. Lipocytes are believed to contract through these substances. In fact, the contraction of lipocytes is induced by SP. Moreover, lipocytes possess endothelin (ET) receptors (ETA, ETB), and the cells are contracted by ET-1 by way of ET receptors in the autocrine or paracrine mechanism. Contraction of lipocytes seems to be related to the enhancement of the intracellular Ca2+ and inositol phosphates. In addition, α-smooth muscle actin, which is a contractile protein, exists in the cytoplasm of lipocytes. Lipocyte contractility may be similar to that of vascular smooth muscle cells. On the other hand, prostaglandin E2, Iloprost, and adrenomedullin cause the elevation of c-AMP levels in lipocytes and relax the cells. In addition, lipocytes produce nitric oxide (NO) and inhibit contractility by an autocrine mechanism related to NO. In this way, lipocytes appear to be associated with the regulation of hepatic sinusoidal microcirculation by contraction and relaxation. In the cirrhotic liver, intralobular innervation is decreased or absent, but ET-1 and NO are overexpressed. These phenomena indicate that lipocytes may play an important role in the sinusoidal microcirculation through these agents rather than through intralobular innervation in liver cirrhosis.
Vena Caval Filters and Anticoagulants for Pulmonary Emboli
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ascariasis Cases on Maine Farms Prompt Food Safety Concerns
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the editors
Authors: Elaine Bell, Lucy Bird, Kirsty Minton, Olive Leavy, Sarah Allan, Rachel David, Isobel Barry, Craig Nicholson, Man Tse, Gillian Young, Simon Bradbrook, Susanne Harris, Vicky Askew, Patrick Managing, Judith Shadwell, Simon Fenwick, Natalie Smith, Laura Firman, Jacques Smit, Deborah Anthony, Marketing Managers, Tim Redding, Leah Rodriguez, Kiersty Darnell, Alison Mitchell, Philip Campbell, Jenny Henderson, Tony Rudland, James Mcquat, Yvonne Strong, Timo Hannay, Alexander Thurrell, Della Sar, Anthony Barrera, Luigi Squillante, Dean Sanderson, Sara Girard, David Bagshaw, Antoine Bocquet, Koichi Nakamura, Asia-Pacific Sales, Kate Yoneyama, Marketing Manager, Peter Yoshihara, Marketing Production Manager, Takesh Murakami, Harpal Gill
Journal: Nature reviews. Immunology (2008)
Pregnancy and an IUD in separate horns of a bicornate uterus
Authors: M. M. Seibel
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I was delighted to read the article by James S. Goodwin, MD, entitled "OKT3, OKT4, and All That" (1981;246:947). In making rounds, there is always an aggressive, zealous, attending physician who asks for the postprandial serum porcelain. It appears that he read about it in some obscure journal from Lower Slobovia. And let us not forget the compleat physician who, when faced with an obviously dying patient, requests a sedimentation rate. Some physicians operate on cloud nine or like to hear themselves talk. Let's get with it, doctors! We have a real world to treat, not laboratory tests.
Peripheral Entrapment Neuropathies of the Lower Extremity
Authors: H. P. Kopell, W. A. L. Thompson
Journal: New England Journal of Medicine (1960)

BECAUSE of the interest in the recent publication on peripheral entrapment neuropathies of the upper extremity,1 it was decided to review these conditions in the lower extremity. An entrapment point occurs in the course of a nerve where the anatomic configuration may cause constriction of the nerve, or, if trauma has occurred to the area, the particular anatomic disposition will maintain the nerve in a state of inflammation. The entrapment phenomenon occurs at these points because there is little latitude for dimensional alteration in the cross-sectional area permitted for the passage of the nerve. The passageway, either an osseofibrous tunnel . . .
Clinical Studies of Styrene Workers: Initial Findings
Authors: William V. Lorimer, Ruth Lilis, William J. Nicholson, Henry Anderson, Alf Fischbein, Susan Daum, William Rom, Carol Rice, Irving J. Selikoff
Journal: Environmental Health Perspectives (1976)

Styrene monomer is a high volume chemical used chiefly in production of polystyrene. A clinical survey of 493 production workers was undertaken at the oldest and largest monomer production, polymerization, and extrusion facility in the U.S. Relative exposure durations and levels were obtained from occupational histories. Significant differences between the high and low exposure groups were found with regard to history of acute prenarcotic symptoms, acute lower respiratory symptoms, prevalence of FEV 1/FV less than 75 per cent, and elevated GCTP. Other liver function tests, chest x-ray, FVC less than 80 per cent, and hematological parameters showed no distinct pattern. A concomitant mortality study has been mounted and is in progress.
KLEPTOMANIA AND "SHOPPING."
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Absence of Morphologic Correlation between Chemical Toxicity and Chemical Carcinogenesis
Authors: James Huff
Journal: Environmental Health Perspectives (1993)

The experimental data set used to evaluate site-specific histopathologic correspondence between the morphologic end points of toxicity and carcinogenicity comprises 130 chemical carcinogenesis studies.Nearly 1500 sex-species-exposure-group experiments were evaluated for a) evidence of toxicity or/and carcinogenicity, b) dose-response relationships, c) site-specific correlations of toxicity and carcinogenicity, and d) correspondence with Salmonella mutagenic- ity.The major conclusions are that chemicals evaluated for long-term toxicity and carcino- genicity in experimental animals divide typically and consistently into three categories: a) chemicals causing organ toxicity without cancer, b) chemicals causing site-specific cancer with no associated toxicity, and c) chemicals causing both toxicity and cancer in the same organ.Few chemicals overall (and none in this data set) fit the remaining group that cause neither toxicity nor carcinogenicity under these protocol conditions.Mutagenicity exhibited no consis- tent pattern with any of these groupings.Only 7 of 53 "positive" chemicals had target organ tox- icity at all sites of carcinogenicity.Just three chemicals showed carcinogenic effects at the highest exposure concentrations without supporting evidence of tumors at the lower levels.From these comparative morphological analyses, and for almost all cases, available data do not support a correlation between chemically induced toxicity or regenerative phenomena and car- cinogenicity.Consequently, until scientific knowledge about molecular mechanisms of chemi- cal carcinogenesis becomes better understood and generally accepted, attempts to use toxicity findings to modify risk assessment processes will be fraught with uncertainty and thus could have a negative impact on public health.
Therapeutics.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tec and Jak2 Kinases Cooperate to Mediate Cytokine-Driven Activation of c-fos Transcription
Authors: Yoshihiro Yamashita, Sumiko Watanabe, Akira Miyazato, Ken-ichi Ohya, Uichi Ikeda, Kazuyuki Shimada, Norio Komatsu, Kiyohiko Hatake, Yasusada Miura, Keiya Ozawa, Hiroyuki Mano
Journal: Blood (1998)
PHYSICIANS' INFLUENCE FELT.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
For AIDS treatment, vaccines, now think genes
Authors: M. F. Goldsmith
Journal: JAMA (1993)

"FOR EVERY PROSPECT there are problems," says William Haseltine, MD, PhD, about the chances of having either an effective treatment or a vaccine for infection with the human immunodeficiency virus (HIV) by the turn of this century—or later. Despite the many advances that have given scientists previously undreamed-of opportunities for intervention against the virus linked with acquired immunodeficiency syndrome (AIDS), Haseltine says, "We don't have the biological parts to get started on a 'Manhattan Project.' We are still in the discovery process. We don't have the knowledge we need to know that any of the possibilities are going to work." The Harvard Medical School professor of pathology spoke at the annual meeting of the American Association for the Advancement of Science, held in Boston, Mass. An AIDS researcher since the syndrome was defined, Haseltine, who is also chief, Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, said, "Do you want