tbuckley/cabot-search huggingface dataset:
Studies Using Lectins to Determine Mineral Interactions with Cellular Membranes
Authors: Brooke T. Mossman, Lucy Jean, Joanne M. Landesman
Journal: Environmental Health Perspectives (1983)

Chrysotile asbestos interacts with mucin-secreting cells of tracheal organ cultures, causing an increase in secretion of mucin into the culture medium. This response occurs in the absence of obvious morphologic damage to tracheal epithelial cells. We speculated that asbestos-induced hypersecretion was regulated by the interaction of fibers with specific carbohydrate residues on the cell surface. To test this hypothesis, lectins, i.e., proteins with a high affinity for mono- and oligosaccharides on the plasma membrane, were added to tissues 30 min before addition of chrysotile. Secretion of mucin into the medium was then determined over a 2-hr period by using incorporation of 3H-glucosamine. Blocking of alpha-D-mannose and alpha-D-glucose residues inhibited chrysotile-induced hypersecretion (p less than 0.05), whereas lectins blocking residues of alpha-D-N-acetylgalactosamine, beta-D-N-acetylglucosamine, alpha-L-fucose and sialic acids were ineffective. Preincubation of cultures with carboxypeptidase A or phospholipase A2, but not with neuraminidase, diminished mucin secretion caused by chrysotile. To determine if the positive surface charge of chrysotile was important in interaction with mucin cells, we examined comparatively the effects of various polycations (cationic ferritin, polylysine, DEAE-dextran) and chrysotile after leaching of fibers to remove Mg2+. Although use of polycations enhanced secretion of mucin, effects were not as striking as those observed with chrysotile. In contrast, leached chrysotile failed to elicit a hypersecretory response. These results suggest the interaction of a positively charged component (presumably Mg2+) of chrysotile with glycolipids and glycoproteins containing terminal residues of alpha-D-mannose or alpha-D-glucose.
Fc receptors in liver sinusoidal endothelial cells in nzb/w fl lupus mice: a Histological analysis using soluble immunoglobulin g?immune complexes and a monoclonal antibody (2.4g2)
Authors: S SYEDAHMED
Journal: Hepatology (1995)

In systemic lupus erythematosus accompanied by the abnormal appearance of circulating immune complexes (ICs), Fcγ receptor (FcR) -mediated IC handling in macrophages including Kupffer cells has been shown previously. However, sinusoidal endothelial cells (SECs) largely ingest soluble immunoglobulin (Ig) G-ICs through FcRs. In this study, the character, antigenic expression, and activity (i.e., ligand-binding capacity of SEC FcRs in NZB/NZW F1 lupus and NZW nonautoimmune mice) were immunohistochemically analyzed using monoclonal antibody (MAb) 2.4G2 to FcRs and peroxidase-antiperoxidase IgG as a ligand on cryosections. MAb 2.4G2 stained SECs and blocked the ligand binding of SEC FcRs in both mice strains. The staining intensities with MAb 2.4G2 in SECs and the FcR activities in SECs alone and all sinusoidal cells in both mice strains reached their maximum values at the age of 5 months. Staining intensities in NZB/W F1 were significantly higher at 1 and 2 months and lower at 9 months than those in NZW. The number of Kupffer cells detected by MAb F4180 to macrophages in both mice strains gradually increased until 5 months, but their number in NZB/ W F1 at 9 months was twice as large as that in NZW. In conclusion, SEC FcRs in mice are low-affinity FcRs that react with MAb 2.4G2. The data of FcR activity suggest no impairment of the FcR-mediated IgG-IC binding on SECs in NZB/W F1 in early life. However, at the late stage of the disease, despite an increased number of Kupffer cells, the capacity of FcR-mediated IgG-IC handling in liver may be reduced by the decreased FcR activity in all sinusoidal cells including SECs and Kupffer cells.
NASAL HYDRORRHEA.
Authors: D. BRADEN KYLE
Journal: JAMA (1896)

True nasal hydrorrhea is an exceedingly rare condition, not being mentioned in many of our works on nasal diseases. It is true there are many conditions which simulate this, but the well authenticated cases are rare. Let us first review the subject as to cause. No special lesion can be named, the peculiar discharge being present under so many different conditions. It may follow trauma, with escape of cerebrospinal fluid, but probably an injury of that degree would prove fatal. It may be associated with nasal growths, as polypi, but in the one case thus far reported Bosworth thinks the polypi were the result and not the cause. Nerve lesions, as involvement of the fifth pair; this would act in two ways, both nerve influence and blood supply would be altered and the condition would properly constitute a reflex neurosis. Carious teeth and cerebral lesions may be exciting causes in
Adverse Effect of Air Pollution on Respiratory Health of Primary School Children in Taiwan
Authors: Pau-Chung Chen, Yu-Min Lai, Jung-Der Wang, Chun-Yuh Yang, Jing-Shiang Hwang, Hsien-Wen Kuo, Song-Lih Huang, Chang-Chuan Chan
Journal: Environmental Health Perspectives (1998)

This study is a part of the Study On Air Pollution and Health In Taiwan (SOAP&HIT), an ongoing research project involving cooperation of several universities in Taiwan. In this study, the objective was to evaluate the effects of ambient air pollution on respiratory symptoms and diseases of school children, in addition to considering indoor air pollution. Six communities were selected: one community located in a rural area (Taihsi), two in urban areas (Keelung and Sanchung), and the other three in petrochemical industrial areas (Toufen, Jenwu, and Linyuan). We sampled 5,072 primary school students in six communities from the main study population of SOAP&HIT. Respiratory health was assessed by evaluation of the children's respiratory symptoms and diseases using a parent-completed questionnaire. Data were analyzed using logistic regression analysis to compute odds ratios of adverse effect. The school children in the urban communities had significantly more respiratory symptoms (day or night cough, chronic cough, shortness of breath, and nasal symptoms) and diseases (sinusitis, wheezing or asthma, allergic rhinitis, and bronchitis) when compared with those living in the rural community. However, only nasal symptoms of children living in the petrochemical communities were more prevalent than in those living in the rural community. Although the association with ambient air pollution is suggestive, the cross-sectional study cannot confirm a causal relationship; thus further studies are needed.
Holding the Mirror up to Medicine
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress Toward Poliomyelitis Eradication — Afghanistan, January 2019–July 2020
Authors: Maureen Martinez, Irfan Elahi Akbar, Mufti Zubair Wadood, Hemant Shukla, Jaume Jorba, Derek Ehrhardt
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Wild poliovirus type 1 (WPV1) transmission is ongoing only in Afghanistan and Pakistan (1). Following a decline in case numbers during 2013-2016, the number of cases in Afghanistan has increased each year during 2017-2020. This report describes polio eradication activities and progress toward polio eradication in Afghanistan during January 2019-July 2020 and updates previous reports (2,3). Since April 2018, insurgent groups have imposed bans on house-to-house vaccination. In September 2019, vaccination campaigns in areas under insurgency control were restarted only at health facilities. In addition, during March-June 2020, all campaigns were paused because of the coronavirus disease 2019 (COVID-19) pandemic. The number of WPV1 cases reported in Afghanistan increased from 21 in 2018 to 29 in 2019. During January-July 2020, 41 WPV1 cases were reported as of August 29, 2020 (compared with 15 during January-July 2019); in addition, 69 cases of circulating vaccine-derived poliovirus type 2 (cVDPV2), and one case of ambiguous vaccine-derived poliovirus type 2 (aVDPV2) (isolates with no evidence of person-to-person transmission or from persons with no known immunodeficiency) were detected. Dialogue with insurgency leaders through nongovernmental and international organizations is ongoing in an effort to recommence house-to-house campaigns, which are essential to stopping WPV1 transmission in Afghanistan. To increase community demand for polio vaccination, additional community health needs should be addressed, and polio vaccination should be integrated with humanitarian services.
Market Reforms for the Health Care System
Authors: Fredric M. Steinberg
Journal: JAMA (1996)

<h3>To the Editor.</h3> —In his thoughtful Commentary,<sup>1</sup>Dr Ginzberg points out several important issues that need to be addressed in any informed debate about changing the status quo in health care. However, Ginzberg relies on some incorrect assumptions that bias his arguments against free market solutions. While discussing the current emphasis on the free market, Ginzberg includes managed care company executives among its enthusiasts. These executives, whose jobs exist because of government interventions such as the HMO [health maintenance organization] Act of 1973 and a current tax code that distorts free choice in insurance decisions, are no friends of the free market and, in fact, consistently oppose free market reforms. It is government decrees that have promoted the growth of these entities, whose incentives to physicians additionally make them no friends of patients. Ginzberg asks why, if "the market has had wide scope to 'do its thing' for the
"'BASAL METABOLISM'—A DISCLAIMER OF RESPONSIBILITY"
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incomplete Conflicts of Interest Disclosures in: Fish Oil and Postoperative Atrial Fibrillation: The Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) Randomized Trial
Authors: Marisa Cruz, Kenneth Covinsky, Eric Widera, Irena Stijacic-Cenzer, Sei Lee, Drs Covinsky, Lee Widera, Stijacic-Cenzer Widera
Journal: JAMA (2013)

The Kaplan-Meier survival curves showed that the differences in survival by point score seen at 4 years were magnified at 10 years (FIGURE).Comment.We validated a mortality index that accurately stratified older adults into groups at varying risk for 10-year mortality.Extending the index from 4 to 10 years did not diminish the model discrimination (validation cohort, C statistics 0.817 vs 0.834; P=.35), suggesting that the risk factors important for 4-year mortality prediction are also important for 10-year mortality prediction.The model compares favorably with other mortality indexes that predict mortality beyond 7 years. 3 One limitation of the index is that it was developed and validated in a single, large, national study and should be validated on a separate population to assess generalizability.Patients identified by this index as having a high risk of 10-year mortality may be more likely to be harmed by preventive interventions with long lag times to benefit, whereas patients identified as having a low risk of 10-year mortality may be good candidates for such interventions.
DEMENTIA PRAECOX AND ENDOCRINE DISORDER
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Controlled trial of γ linolenic acid in Dukes's C colorectal cancer
Authors: Janet Treasure, F Russell, Brian Murby
Journal: BMJ (1987)

Correction Controlied trial of y linolenic acid in Dukes's C colorectal cancer An error occurred in the figure showing survival in patients and controls in this paper by M B McIllmurray and W Turkie (16 May, p 1260).The correct figure is shown below.Treatment 80-Control
Pseudomembranous Colitis
Authors: Leonard S. Jacob
Journal: JAMA (1980)

<h3>To the Editor.—</h3> I was somewhat disturbed by the conclusions drawn by Tan et al (242:749, 1979) with regard to the prophylactic use of antibiotics. Indeed cephalosporin usage in producing pseudomembranous colitis is rare.<sup>1</sup>In their case they present a 67-year-old healthy woman who underwent a vaginal hysterectomy receiving prophylactic cephaloridine before and for three full days after her surgery. When this patient unfortunately died of pseudomembranous colitis, the authors stated that their case illustrates why there is a need for a serious reassessment of the use of prophylactic antibiotics in surgical procedures. I disagree. A prospective study done as early as 1975<sup>2</sup>clearly indicates that correct antibiotic prophylaxis for vaginal hysterectomy consists of the particular antibiotic available to the operating room and only two subsequent doses postoperatively. Continuing prophylactic antibiotic therapy beyond this is of no value. This was again demonstrated by Ledger et al<sup>3</sup>in
Forebrain yields clues to Alzheimer's disease
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The limitations of free association
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DYSPNEA
Authors: Max Wishnofsky
Journal: JAMA (1935)

<h3>To the Editor:—</h3> In an article entitled "Dyspnea" published inThe Journal, Nov. 10, 1934, table 2, page 1444, Dr. J. C. Meakins assigns low blood pressure as the cause for dyspnea in insulin shock. The majority of investigators have found that insulin shock is accompanied by an elevation of systolic and a lowering of diastolic pressure, with a consequent increase in pulse pressure. It has been postulated by Cannon and his associates that this effect is due to an increase in secretion by the suprarenals.
Persistent Nocardemia Following Renal Transplantation
Authors: Morrell M. Avram, S. Ramachandran Nair, Henry I. Lipner, Charles E. Cherubin
Journal: JAMA (1978)

Pulmonary nocardiosis occurred in a renal homotransplant patient and was diagnosed by persistently positive blood cultures. Infection developed at a time when efforts were being made with moderate dosages of immunosuppressive drugs to prevent rejection of the transplant. The subsequent nocardemia lasted for one week. The remaining kidney function was preserved, and the patient had a very favorable outcome because of early diagnosis and prompt treatment with sulfisoxazole. (<i>JAMA</i>239:2779-2780, 1978)
Audibility of the fourth heart sound. A prospective, "blind" auscultatory and polygraphic investigation
Authors: E. H. Rectra
Journal: JAMA (1972)

An auscultatory search for a fourth heart sound (S<sub>4</sub>) was performed by two independent "blind" auscultators who did not know the medical status of 196 consecutively examined subjects, ages 50 to 80 years. Phonocardiograms (PCGs) and other tracings taken after recording the results were measured by a third observer who was also "blind." Results of this investigation indicate that any tendency for rapid completion of atrial excitation and early onset of S<sub>4</sub>appears to determine the auscultatory audibility of the fourth heart sound. Conversely, a tendency to later completion of atrial excitation and a later onset of S<sub>4</sub>will make it auscultatorily inaudible, although recordable even at considerable amplitude by PCG. The relative amplitude and frequency of S<sub>4</sub>were not significantly related to its audibility. The presence or absence of disease was not significantly related to the presence or absence of S<sub>4</sub>by PCG or to its audibility when present.
Resident Seats Available on AMA Councils, ACGME
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal