tbuckley/cabot-search huggingface dataset:
CONTRIBUTORY NEGLIGENCE OF PATIENT AS DEFENSE TO CHARGE OF MALPRACTICE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphocyte transformation. Absence of increased responses in alleged halothane jaundice
Authors: B. Walton
Journal: JAMA (1973)

In vitro tests for cell-mediated immunity were conducted in a group of patients and physicians whose histories suggested the possibility of hypersensitivity to halothane. The results of tests for lymphocyte transformation in these subjects were not significantly different from the results in a group of normal controls. These findings, therefore, have failed to confirm previously reported work, in which it was claimed that positive lymphocyte transformation was demonstrated in ten of 15 patients with alleged halothane hepatitis.
Macrophages, smooth muscle cells and tissue factor in unstable angina: Implications for cell mediated thrombogenicity in acute coronary syndromes
Authors: Pedro R. Moreno, Victor H. Bernardi, Julio Lopez-Cuellar, Igor F. Palacios, Herman K. Gold, Yale Nemerson, Valentin Fuster, John T. Fallon
Journal: Journal of the American College of Cardiology (1996)
Early and late changes in fasting and absorptive plasma amino acids and ammonia after distal splenorenal shunt in cirrhosis
Authors: F Trevisani
Journal: Hepatology (1994)

Levels of plasma amino acids, ammonia, glucagon and insulin and their 5-hr responses to a protein feeding were evaluated before and sequentially (3 mo and 1 yr) after distal splenorenal shunt in 10 patients with cirrhosis belonging to Child-Pugh's class A or B. An index of glucagon effectiveness (plasma glucose/glucagon) was also calculated. These parameters were related to liver test results, portal vein diameter and mental state, and they were compared with those found in seven patients undergoing sclerotherapy of esophageal varices with comparable liver function (control group). Liver test results and levels of plasma insulin did not change in either group. Shunt significantly increased levels of fasting tyrosine, methionine, ornithine, arginine, histidine, ammonia and glucagon with respect to the control group; it also significantly decreased levels of leucine, valine, glucagon effectiveness and portal vein diameter. The elevation of levels of tyrosine, ammonia and the sum of arginine and ornithine was correlated directly with the increase in glucagon and inversely with the decline in glucagon effectiveness. Tyrosine increase was also correlated with the reduction of portal vein diameter. One shunted patient showed mild hepatic encephalopathy. Protein feeding did not worsen the mental state of patients before and after the operation. Surgery significantly increased the 5-hr response to the meal of gluconeogenic amino acids; its rise was again correlated with the changes in glucagon plasma levels and effectiveness. Although the absorptive levels of plasma ammonia were significantly higher 1 yr after surgery, its 5-hr response barely rose. In cirrhotic patients with a relatively preserved liver function, distal splenorenal shunt progressively worsened the fasting plasma profile of nitrogen compounds and the response to protein ingestion of gluconeogenic amino acids. The decline of portal blood flow and glucagon effectiveness may be causal factors. Despite this, the “cerebral” tolerance to a moderate oral load of protein was not reduced by surgery. (Hepatology 1994;19:329–338).
Cardiopulmonary Resuscitation
Authors: Max Bader
Journal: JAMA (1978)

<h3>To the Editor.—</h3> In "Laymen May Outscore Physicians in Cardiopulmonary Resuscitation" (239:391-392, 1978), the question is asked whether laymen forget cardiopulmonary resuscitation (CPR) techniques. I have been personally informed by two lay people who had had CPR training that they failed to employ their skill on witnessing cardiac arrests outside the hospital because they felt too unsure of themselves and wanted to do no wrong. It had been too long since they had their CPR training. I was called for both cases but arrived too late to be of benefit. This points up the need for periodic CPR refresher courses for laymen and the desirability for lay people who have successfully completed a course to carry a wallet-sized reminder card with appropriate diagrams and the steps of what to to. In addition, when a person is known to have coronary heart disease, it might be appropriate to encourage his family
Error in Article Information
Journal: JAMA Internal Medicine (2014)

Russell P. Harris, MD, MPH; Stacey L. Sheridan, MD, MPH; Carmen L. Lewis, MD, MPH; Colleen Barclay, MPH; Maihan B. Vu, DrPH, MPH; Christine E. Kistler, MD, MASc; Carol E. Golin, MD; Jessica T. DeFrank, PhD; Noel T. Brewer, PhD
Errors in Abstract, Statistical Analysis, and Results
Authors: Thomas Niederkrotenthaler
Journal: JAMA Psychiatry (2019)

Jaimie L. Gradus, DMSc, DSc; Anthony J. Rosellini, PhD; Erzsébet Horváth-Puhó, PhD; Amy E. Street, PhD; Isaac Galatzer-Levy, PhD; Tammy Jiang, MPH; Timothy L. Lash, DSc; Henrik T. Sørensen, DMSc, MD
Second Cancers Affect the Clinical Outcomes of Patients with Chronic Lymphocytic Leukemia (CLL) Treated with Frontline FCR-Based Therapy.
Authors: Long Xuan Trinh, Young Kwang Chae, Preetesh Jain, Susan Lerner, Ohad Benjamini, Xuemei Wang, Michael J. Keating
Journal: Blood (2012)
Activation of ATP-sensitive potassium channels: a novel pharmacological approach to myocardial protection?
Authors: D. J. Hearse
Journal: Cardiovascular Research (1995)

Journal Article Activation of ATP-sensitive potassium channels: a novel pharmacological approach to myocardial protection? Get access David J. Hearse David J. Hearse * Cardiovascular Research, The Rayne Institute, St. Thomas' Hospital, London SE1 7EH, UK *Tel. (+44-171) 928 9292 ext. 2583; Fax (+44-171) 928 0658. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 30, Issue 1, July 1995, Pages 1–17, https://doi.org/10.1016/S0008-6363(95)00004-6 Published: 01 July 1995 Article history Received: 07 March 1995 Accepted: 10 April 1995 Published: 01 July 1995
Cardiac magnetic field mapping at rest detects coronary restenosis in patients after percutaneous transluminal coronary angioplasty and stent implantation Alexander Schirdewan, Andrey Gapelyuk, Daniela Selbig, Udo Meyerfeldt. Henry Schuett, Michail Primin, Frank Uhlich, Juergen Waigand, Rainer Dietz, Franz Volhard Hospital, Charite, Humboldt University, Berlin, Germany
Journal: Journal of the American College of Cardiology (2001)
Cisplatin-DNA Damage and Repair in Peripheral Blood Leukocytes in Vivo and in Vitro
Authors: Meenakshi Dabholkar, Lita Bradshaw, Ricardo J. Parker, Indrani Gill, Frieda Bostick-Bruton, Franco M. Muggia, Eddie Reed
Journal: Environmental Health Perspectives (1992)

We have extended our studies on the relationship between cisplatin/carboplatin-induced DNA damage in readily accessible tissue(s) and clinical response to therapy. Such an approach may assist in the study of cancer drug resistance and in establishing parameters for assessing human populations for sensitivity to DNA damaging agents in the environment. Platinum-DNA adduct levels were measured by atomic absorbance spectrometry. DNA repair capacity was assessed in human T-lymphocytes by the ability to repair cisplatin lesions in cellular DNA or in transfected plasmid DNA. In a
Staffing pattern of a health maintenance organization. A systems approach
Authors: A. S. Golden
Journal: JAMA (1978)

A systems analysis approach was applied to a study of health provider jobs in a health maintenance organization to develop a proposal for an improved staffing pattern and an appropriate training curriculum for the provider. Physicians reported performing 512 ambulatory care tasks; health associates, 372; and health assistants, 284. Overlap was found among each group, especially in data-gathering tasks. This led to reallocation of tasks, with the most complex but smallest number assigned to the physician, and the least complex but highest number assigned to the assistant. In turn, a staffing pattern was suggested whereby a team of two physicians, four associates, and eight assistants would be able to manage the visits of 10,000 patients. (<i>JAMA</i>240:1969-1972, 1978)
CORRECTION
Journal: American Journal of Psychiatry (2018)

appropriate evaluations and treatments are not realized without considering socio-cultural realities.To this end, the establishment of the Perspectives in Global Mental Health section within the Journal is an important attempt to accumulate wisdom from transcultural psychiatry.Indeed, we believe that psychiatrists should be experts who are able to read changes in evolving social periods and to make multidirectional considerations of the psychiatric problems that face their patients.
Reply
Authors: Harshad Devarbhavi, Sujata Raj
Journal: Hepatology (2016)

We thank Dr. Medina-Caliz and colleagues for their interest in our article.1 We agree with the authors' observations that concomitant skin and liver injury needs better characterization and needs to be pursued with greater vigor across all drug-induced liver injury DILI consortia. The skin and the liver are the two largest organs in the body and are commonly involved in adverse drug reactions (ADRs). However, DILI associated with concurrent skin injury has not been adequately studied. Cutaneous reactions are common and easily recognized; the implicated drug is stopped before concurrent asymptomatic liver involvement may progress to clinically significant injury. Indeed, mild-to-moderate liver injury may go unrecognized if liver biochemical tests are not carried. At other times, clinically significant hepatitis may overshadow cutaneous reactions, thereby influencing outcome. Therefore a close collaboration between dermatologists and hepatologists is required in order to decipher the full extent and patterns of concurrent liver and skin injury and its outcome. Hepatologists and dermatologists view ADRs differently; they attend different conferences and write to different journals and rarely do the twain meet. In one review, liver injury was the commonest extracutaneous organ involved in up to 94% of patients in DRESS (drug-reaction with eosinophilia and systemic symptoms) and was closely linked to mortality with 8 of the 9 deaths attributed to hepatitis.2 The characteristics of liver injury were not mentioned. Another striking feature of concurrent skin and liver injury is the rather narrow list of drugs and cross-reactive medications that can produce disease.1-3 In one review, only 44 drugs were implicated as causative agents in DRESS, but only a handful of them (four to five in number) constituted a majority of cases.2 Aromatic antiepileptic drugs, sulphonamides, allopurinol, and nevirapine were commonly implicated; the same group of drugs that were responsible in our series of DILI and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).1 Why the skin and liver and are involved concurrently is unknown. Drugs such as sulphonamide or dapsone can undergo bioactivation in keratinocyte to form drug-protein adducts and elicit an immune response4; a process similar to that occurs in the liver. Human leukocyte antigen (HLA) association with ADR is another factor. HLA-B*1502 is common in Asians and is specific for carbamazepine-induced SJS/TEN, but not other reactions, whereas HLA-DRB1*0101 is implicated only in nevirapine-induced skin and liver injury when CD4 counts are ≥25%.5 To better delineate the role and extent of injury from drug, genetic, and environmental factors, close collaboration between drug-induced liver and skin injury experts are needed. Harshad Devarbhavi, M.D.1 Sujata Raj, M.D.2 1Department of Gastroenterology 2Department of Dermatology St. John's Medical College Hospital Bangalore, India
Effect of a xanthine analog on human hepatocellular carcinoma cells (Alexander) in culture and in xenografts in SCID mice
Authors: L Marucci
Journal: Hepatology (1997)

Hepatocellular carcinoma (HCC) frequently overexpresses the MDR1 gene and is resistant to drugs transported by the multidrug-resistance efflux pump. A xanthine analog, 1-(11-dodecylamino-10-hydroxyundecyl)- 3,7-dimethylxanthine (CT-2584,CTI), is cytotoxic to many tumors in culture and was four times more effective than verapamil in inhibiting Rhodamine 123 secretion in MDR1-overexpressing Chinese hamster ovary cells. However, studies using PRF/PLC/5 (Alexander) cells revealed that CT-2584 is cytotoxic by another mechanism not involving inhibition of MDR1 function. Alexander cells have integrated the hepatitis B surface antigen (HBsAg) gene and quantitatively secrete HBsAg. The parent cell line, Alex 0, has low MDR1 expression and is drug-sensitive, whereas a derived line, Alex 0.5, is drug-resistant and overexpresses MDR1 100 times. Both cell lines were similarly killed within 24 or 48 hours by CT-2584. Freshly isolated rat and human hepatocytes were considerably more resistant to killing by CT-2584. In vivo, CT-2584 significantly reduced tumor growth in SCID mice bearing Alex 0 or 0.5 xenografts as determined by serial measurements of HBsAg. Hepatic parenchyma was normal, whereas apoptosis and cellular loss were observed in xenografts. The xenograft model is useful for testing pharmacological therapy of HCC.
General internal medicine
Authors: J. R. Feussner
Journal: JAMA (1993)

With the increasing demand for and cost of medical care, policymakers recognize the need to reconsider the organization of health care in the United States. Any reordering of health care priorities will focus on providing optimum care at minimum cost and can only advance the role of general internal medicine. During the past year, research relevant to general internal medicine focused on several issues: (1) more cost-effective approaches to diagnosis and treatment of common clinical problems using low-technology approaches that include the clinical history and physical examination; (2) the role of gender in medical care, focusing on women as physicians, patients, and subjects in research studies; and (3) internal medicine manpower overall and general internal medicine specifically. Multiple research reports have documented the utility of routine clinical observations for establishing diagnoses and targeting therapies for common clinical problems.<i>JAMA</i>has even begun a new series of articles called the "Rational
Alcohol-dependent doctors.
Journal: BMJ (1979)

inability to read aloud due to conduction aphasia or to Broca's motor aphasia (by definition alexia refers to comprehension), incorrect reading of part of a word (as with a visual field defect or neglect), unrecognised developmental dyslexia, mental retardation, confabulation in psychiatric disorders, confusional states, and psychogenic disorders such as schizophrenia.3
GUILLAIN-BARRÉ SYNDROME AN ALLERGIC REACTION?
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibodies' Role in Infertility Studied
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health in Colleges and Universities
Authors: Dana L. Farnsworth, Augustus Thorndike
Journal: New England Journal of Medicine (1956)

THE health of students, faculty and staff of colleges and universities is gradually becoming a source of official concern to the governing authorities of institutions for higher education. The concept is slowly gaining acceptance that some provision should be made by the college or university for the promotion and maintenance of health and for the treatment of illness or injury whenever they occur. Community resources, however excellent they may be, do not meet the needs of college personnel without a local organization or service designed to bring the student or staff member and the physician and his professional resources together . . .
Contents of the next issue
Journal: Annals of Oncology (2000)

In this issue Tobacco and tobacco smokeWe have known with some certainty that cigarette smoking causes lung cancer for at least forty years, have understood that it causes the large majority of lung cancer for thirty to forty years, and that it is one of the worlds most avoidable causes of death for at least twenty to thirty years.We know that smoking causes a number of other types of cancer and is a major avoidable factor involved in causation of heart disease and many other fatal and non-fatal conditions.The adverse effects of second-hand smoke have been progressively demonstrated over the past fifteen years.In this issue, Gray and Boyle, in an extended editorial, consider how tobacco and tobacco smoke could now be regulated and why this should be of importance to all oncologists.
Pulmonary carcinogenicity of inhaled particles and the maximum tolerated dose
Authors: G Oberdörster
Journal: Environmental Health Perspectives (1997)

Chronic inhalation bioassays in rodents are used to assess pulmonary carcinogenicity for purposes of hazard identification and potentially for risk characterization.The influence of high experimental doses on tumor development has been recognized for some time and has led to the concept of maximum tolerated dose (MTD) for dose selection, with the highest dose being at the MTD.Exposure at the MTD should ensure that the animals are sufficiently challenged while at the same time the animal's normal longevity is not altered from effects other than carcinogenicity.A characteristic of exposure-dose-response relationships for chronically inhaled particles is that lung tumors are significantly increased only at high exposure levels, and that lung tumors are seen in rats only but not in mice or hamsters.This lung tumor response in rats is thought to be secondary to persistent alveolar inflammation, indicating that the MTD may have been exceeded.Thus, mechanisms of toxicity and carcinogenicity may be dose dependent and may not operate at lower doses that humans normally experience.Despite awareness of this problem, carcinogenicity bioassays that evaluate particulate compounds in rodents have not always been designed with the MTD concept in mind.This is due to several problems associated with determining an appropriate MTD for particle inhalation studies.One requirement for the MTD is that some toxicity should be observed.However, it is difficult to define what degree of toxic response is indicative of the MTD.For particle inhalation studies, various noncancer end points in addition to mortality and body weight gain have been considered as indicators of the MTD, i.e., pulmonary inflammation, increased epithelial cell proliferation, increased lung weight, impairment of particle clearance function, and significant histopathological findings at the end of a subchronic study.However, there is no general agreement about quantification of these end points to define the MTD.To determine whether pulmonary responses are indicative of the MTD, we suggest defining an MTD based on results of a multidose subchronic and chronic inhalation study with a known human particulate carcinogen, e.g., asbestos or crystalline silica.Quantification of effects in such a study using the noncancer end points listed above would identify a dose level without significant signs of toxicity at the end of the subchronic study.If this dose level still results in significant lung tumor incidence at the end of the chronic study.We will have a sound basis for characterizing the MTD and justifying its use in future particle inhalation studies.Also, a better understanding of cellular and molecular mechanisms of particle-induced lung tumors is needed to support the MTD concept.
Fractionated Doses of Radioiodine for Ablation of Postsurgical Thyroid Tissue Remnants
Authors: EMIL ARAD, KATHLEEN FLANNERY, GEORGE A. WILSON, ROBERT E. OʼMARA
Journal: Clinical Nuclear Medicine (1990)

ARAD, EMIL M.D.; FLANNERY, KATHLEEN M.D.; WILSON, GEORGE A. M.D.; O'MARA, ROBERT E. M.D.Author Information
Correction: Systems-Level Analysis of Neuroblastoma Tumor-Initiating Cells Implicates AURKB as a Novel Drug Target for Neuroblastoma
Journal: Clinical Cancer Research (2010)

In this article (Clin Cancer Res 2010;16:4572–82), which was published in the September 15, 2010, issue of Clinical Cancer Research (1), there was an error in Table 1. The data in the Description column for the NB121 row should read: Bone marrow metastasis, diagnosis.