tbuckley/cabot-search huggingface dataset:
SAT0267 Elevated levels of WNT3A and low levels of DICKKOPF-1 in serum are associated with syndesmophyte formation in ankylosing spondylitis
Authors: E. Klingberg, M. Nurkkala, H. Carlsten, H. Forsblad-d’Elia
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Ankylosing spondylitis (AS) is associated with both pathologic formation of new bone and enhanced bone resorption. <h3>Objectives</h3> The objectives of this study were to assess a panel of biomarkers reflecting bone turnover and to determine their relationship with syndesmophyte formation, bone mineral density (BMD) and disease activity in AS. <h3>Methods</h3> All patients at the study centres fulfilling the modified New York criteria of AS were invited to participate. Exclusion criteria were psoriasis and inflammatory bowel disease. Spinal mobility was assessed for calculation of BASMI and the patients answered questionnaires. BASDAI, ASDAS and CRP were chosen as disease activity parameters. Lateral spine radiographs were scored for syndesmophyte formation (mSASSS). BMD was measured with dual energy x-ray absorptiometry (DXA). Levels of biomarkers were measured with sandwich enzyme-linked immunosorbent assays (ELISA) in patient sera and compared with levels of healthy blood donor controls. The biomarkers studied were: Wingless proteins (Wnt3a, Wnt5a), Dickkopf-1 (Dkk-1), sclerostin, soluble receptor activator of nuclear factors-κB ligand (sRANKL) and osteoprotegerin (OPG) <h3>Results</h3> 204 patients (57% men) with a mean age of 50±13 years and disease duration 15±11 years and 80 age and sex matched controls were included. The AS patients had significantly higher levels of Wnt3a (3.72±0.99 vs. 2.88±0.84 ng/mL; p&lt;0.001) and lower levels of sclerostin (35.33±21.54 vs. 38.33±13.96 pmol/L; p=0.014) compared with the controls. Wnt3a was positively correlated with BASMI (r<sub>S</sub>=0.219; p=0.002) and mSASSS (r<sub>S</sub>=0.196; p=0.005) but negatively correlated with BMD femoral neck (r<sub>S</sub>=-0.160; p=0.023). High CRP was significantly correlated with lower levels of sclerostin (r<sub>S</sub>=-0.208, p=0.003) and Dkk-1 (r<sub>S</sub>=-0.140, p=0.045). Age (r<sub>S</sub>=0.389; p&lt;0.001) and male sex (r<sub>S</sub>=0.377; p&lt;0.001) and low femoral neck BMD (r<sub>S</sub>=-0.187; p=0.008) were significantly correlated with increasing mSASSS. After adjusting for age and sex in multiple linear regression high Wnt3a (B=2.71; p=0.017) and low Dkk-1 (B=-0.002; p=0.025) remained independently associated with increasing mSASSS (R<sup>2</sup>=0.333). Low sclerostin (B=0.012; p&lt;0.001) and high mSASSS (B=-0.010; p=0.003) were independently associated with low Z-score for BMD femoral neck (R<sup>2</sup>=0.091). <h3>Conclusions</h3> The understanding of bone biomarkers in AS is challenged by the two enhanced opposite bone remodelling processes of the disease. The results of this study indicates that elevated Wnt3a could be a marker for syndesmophyte formation in AS. <h3>Disclosure of Interest</h3> None Declared
DIPHTHERIA BACILLI IN WELL PERSONS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guidelines for Reporting of Figures and Tables for Clinical Research in Urology
Authors: Andrew J. Vickers, Melissa J. Assel, Daniel D. Sjoberg, Rui Qin, Zhiguo Zhao, Tatsuki Koyama, Albert Botchway, Xuemei Wang, Dezheng Huo, Michael Kattan, Emily C. Zabor, Frank Harrell
Journal: European Urology (2020)
Dieting and peroneal nerve palsy
Authors: D. G. Sherman
Journal: JAMA (1977)

In seven patients, peroneal nerve palsies developed while they were on weight-reduction diets. Five palsies were unilateral; two, bilateral. All patients recovered following diet modification. Therapeutic weight loss, of itself, can cause foot-drop. The prognosis is uniformly good. (<i>JAMA</i>238:230-231, 1977)
Thrombogenesis
Authors: Daniel Deykin
Journal: New England Journal of Medicine (1967)

I SHOULD like to develop a concept of the normal hemostatic mechanism and of the pathogenesis of thrombosis consistent with the pathways of coagulation of blood as they are now understood. When possible I shall draw on in vivo experiments to buttress my remarks. The understanding of blood coagulation, however, is still imperfect, and knowledge of it derives primarily from tests performed outside the body.Pathologists recognize 3 types of thrombus, each of which may have a different pathophysiology. The first is the red thrombus, which is composed primarily of red cells and fibrin. Its morphology closely resembles that of . . .
Use of magnesium in pre-eclampsia is growing
Journal: BMJ (1998)

Colloids no better than crystalloids for fluid replacement in hypovolaemic patientsFor decades controversy has existed over the relative benefits of colloid and crystalloid solutions for fluid resuscitation of hypovolaemic patients.In their systematic review of randomised controlled trials Schierhout and Roberts (p 961) found that, compared with crystalloids, use of colloids was associated with an increase in absolute risk of mortality of 4%.There was no evidence for differences of effect among different types of injury necessitating fluid resuscitation.The authors conclude that there is no evidence to support the continued use of the more expensive colloids for acute volume replacement in critically ill patients.
[386] Withdrawn
Authors: T Erichsen', T Lankisch', U Ehmer', T Gillman', R Remme12, M Manns', C Strassburg' . ', J Garcia-Banuelos, F Galvez-Gastelum, L Ruiz-Corro, A Segura, J Gonzalez-Cuevas, J Armendariz-Borunda, M Gonzalez-Carmona', A Timmerman', E Raskopfl, M Kornek', . Schmidt-Wolf1, W Caselmann1~2, T Sauerbruchl, V Schmitzl
Journal: Journal of Hepatology (2007)
Neurological complications of systemic diseases. II.
Authors: A H Roberts
Journal: BMJ (1970)

Last week Dr. Roberts considered the neurological complications of diabetes and neoplastic disorders.His article is concluded this week.) Collagen DiseasesGiven some latitude in classification, it is possible to con- sider under this heading the group of inflammatory diseases of collagen tissue which include rheumatoid arthritis, giant cell arteritis and polymyalgia rheumatica, polyarteritis nodosa, dis- seminated lupus erythematosus, and the variants of polymyositis.The most prevalent of these, rheumatoid arthritis, which affects perhaps 3'y,, of the population, is the least frequently
Neurological Surgery
Authors: Russel H. Patterson
Journal: JAMA (1984)

New technology continues to make a heavy impact on contemporary neurosurgery. In retrospect, modern neurosurgery probably dates to about 15 years ago, when the operating microscope came into wide use and provided the magnification and lighting necessary to operate on small structures in the head and spinal canal. Technology has continued to advance, and neurosurgeons now are exploring new tools, including the laser, the ultrasonic aspirator, and the use of ultrasonic brain scanning in the operating room to identify lesions deep in the brain. The most popular laser in neurosurgery is the carbon dioxide laser. The laser beam is directed by a series of mirrors in an articulated arm into the operating microscope and into the operating field. The surgeon can move the spot of light energy about the field using a joystick, and when the spot is centered on the target, usually a tumor, the laser is energized by
Recently I moved back to Wales after spending nearly eight years away. I have been working mainly in accident and emergency (A&amp;E), and have completed the first part of my FACEM(Aus). I am unlikely now to return to Australia, however, as I have two young children; the youngest is six months. I am struggling with which path to take because getting an SpR in A&amp;E would mean doing most of the training again, as well as more exams. I have been interested in general practice for some time and …
Authors: Bill Irish
Journal: BMJ (2007)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site <b>www.bmjcareers.com/advicezone</b>
Veterans With Epilepsy Need More Than Seizure Control
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antenatal diagnosis and therapeutic trends in sphingolipidoses
Authors: L. Schneck
Journal: JAMA (1974)

OF the 1,500 distinguishable human diseases that are genetically determined, a recent review compiled more than 40 for which a prenatal diagnosis was potentially possible.<sup>1</sup>This register includes diseases caused by chromosomal aberrations, sex-linked diseases, and metabolic disorders. In contrast to diseases that involve the interaction or blending of many different aberrant genes—polygenetic or multifactorial diseases—and usually appear somewhat later in life (eg, diabetes and atherosclerosis), metabolic diseases usually involve single gene mutations and adhere to the precepts of mendelian genetics. This means that armed with the appropriate information in regard to the dominant and recessive genetic traits, one can predict the statistical probability of the genetic nature of the offspring in regard to the disease entity. In biochemical terms, the best understood group of genetic diseases are those in which a single gene mutation is involved, usually affecting the expression of an enzyme, hormone, or a particular protein.
1989 spring meeting of the British Society of Gastroenterology. 12-14 April, Bradford.
Authors: S Brown, D Kerrigan, G Huichin-, M Langman, W Kmioi, M Pinho, K Yoshioka
Journal: Gut (1989)

Prediction of rebleeding after peptic ulcer haemorrhage relies on clinical and endoscopic criteria which are accurate in only a variable proportion of cases.In this study we have assessed prediction of rebleeding in peptic ulcers using a trans- endoscopic vascular detector (TVD) to compare the presence of a Doppler signal (+/-) in relation to an ulcer base with visual stigmata of recent haemorrhage (SRH).on August 14,
Endoscopy/endoscopic ultrasound
Authors: J Galmiche, C De Meynard, J Abitbol, B Scherrer2, B Fraitag
Journal: Gut (1994)

3rd UEGW Oslo 1994 A9 viding the patients according to the criteria of Colin-Jones gave very small groups and offered no further information.The effects of the drug on individ- ual symptoms, likewise, did not reach significance.Conclusion: Our results do not support a role for gastric acid production in generation of functional upper dyspepsia and do not warrant prescription of Omeprazole to patients suffering from non-ulcer dyspepsia.
Procaine Amide in Ventricular Fibrillation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cooking fuel smoke and respiratory symptoms among women in low-income areas in Maputo
Authors: A Ellegård
Journal: Environmental Health Perspectives (1996)

Thie assciation between :tposure to air poilution from cooking foals an4 health.aswas studied in Ma a1200 radol s e w e rsidiing n. the suburbs of Maputo iwere l an 218 were monitored fotr Aipl:lution.The fuels .mostcommonly used woo a e t and liquified peleum (LPG).Wood users were esposed to significantlydhigher levels of particulate pollution-durngcooking time (1200 pg/m3) than ch'acoal usrn '(54 j and users of modern fuels (LPG and electricity) (200-380 pg/m3) Wood' user wet*:fid to have si c more cough pms thn 6 r m This assecioaaon eiuinr of awel-.. .. roumental varisbles.There w.diffiurn in cough Z -.users and
Angiology, Baltmore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEW
Authors: E. LEE
Journal: JNCI Journal of the National Cancer Institute (1993)

BOOK REVIEW Get access Current Therapy in Oncology John E. Niederhuber . St. Louis : Mosby-Year Book , 1993 . 663 pp., illus. $99. ISBN 1-55664-229-6 . EDWARD LEE EDWARD LEE University of Maryland Cancer Center22 S. Greene St. Baltimore, MD 21201 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 7, 7 April 1993, Pages 579–580, https://doi.org/10.1093/jnci/85.7.579 Published: 07 April 1993
Pancreatic Surgery
Authors: Richard B. Cattell, Kenneth W. Warren
Journal: New England Journal of Medicine (1951)

Surgical TreatmentSurgical procedures employed in chronic relapsing pancreatitis and pancreatolithiasis can be divided into those directed toward the pancreas, those indirectly affecting the pancreas and a combination of the direct and indirect procedures.Indirect Methods Biliary-Tract Operations Cholecystectomy and choledochostomy. Gambill, Comfort and Bagenstoss61 have emphasized the importance of eliminating pathologic conditions of the biliary tract, when present, in the management of the disease. They observed remissions of the disease of one to eight years' duration after cholecystectomy or cholecystectomy plus choledochostomy in approximately one third of the cases. Subsequent remissions were also observed after secondary choledochostomy with . . .
1,1-Dichloroethylene Hepatotoxicity: Proposed Mechanism of Action and Distribution and Binding of 14 C Radioactivity Following Inhalation Exposure in Rats
Authors: Rudolph J. Jaeger, Lawrence G. Shoner, Linda Coffman
Journal: Environmental Health Perspectives (1977)

1-Dichloroethylene is reported to produce renal tumors in male mice.It is an hepatotoxin in fasted rats after inhalation.We found that trichloropropane epoxide, an inhibitor of epoxide hydrase, enhances hepatic injury as measured by serum sorbitol dehydrogenase elevation.A significant elevation of hepatic citric acid concentration was seen in fasted but not fed rats.We hypothesized that mitochondrial injury was associated with inhibition of the tricarboxylic acid cycle and postulated that monochloroacetic acid was a toxic metabolite of 1,1-DCE.Fluoroacetic acid and chloroacetic acid were similar in their ability to inhibit oxygen uptake when pyruvic and malic acids were substrates in isolated mitochondria sup- plemented with adenosine diphosphate.In experiments where 1,1-DCE metabolism was estimated, no difference between the rate of uptake in a 2-hr period was detected between fed and fasted animals.Urinary output of radioactivity at 26 hr for fed and fasted rats was similar.Water-soluble (i.e.TCA-soluble) 1,1-DCE metabolites were found in tissues of fasted rats in excess of that seen in fed rats.The kidney had the largest concentration of total metabolites.Tissue-bound, or TCA-insoluble, radioactivity was associated with the mitrochondrial and microsomal fraction of fasted rats in excess of that seen in fed rats.The disappearance of TCA-insoluble radioactivity from the mitochondrial and microsomal fractions was comparable in rate between fed and fasted rats respectively.These results suggest that 1,1-DCE is metabolized quite rapidly in the organism to TCA-soluble components which are excreted by the kidneys.Metabolites of 1,1-DCE may enter the metabolic pool, since a reasonably short turnover of 14C-labeled, bound material was observed.The metabolite of 1,1-DCE appears to inhibit the mitochondria so that citric acid accumulates.This may occur by a process of lethal synthesis.
Legends of Spermatogenesis
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sea Change
Authors: Gaetan Sgro
Journal: Annals of Internal Medicine (2015)

Ad Libitum20 January 2015Sea ChangeGaetan Sgro, MDGaetan Sgro, MDFrom Pittsburgh, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-1074 Audio Reading - “Sea Change” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Sea Change," by G. Sgro. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I remember ribbons upon ribbons ripplingin every dreamable direction and shadeof light and sea and sky.I so much more than remember.Can still feel the earth's firmnessunderneath my shoulder bladesmy fingers and toes outstretchinglike scarps only testing the bay.I still see through an afternoon hazethose low toasted hills in the distance.Still, when I want to, inhabitthe cool evening scent of dried grasses.I have grown more than tired of menbragging how blue the Pacific.I used to press the eyepieces so firmlyagainst my sockets, I earned markswatching the swells lumber in.Not once did I ask where the wind ... Author, Article, and Disclosure InformationAffiliations: From Pittsburgh, Pennsylvania.Current Author Address: Gaetan Sgro, MD; e-mail, gaetan.[email protected]gov PreviousarticleNextarticle Advertisement Audio Reading - “Sea Change” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Sea Change," by G. Sgro. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 20 January 2015Volume 162, Issue 2Page: 99KeywordsGamesShoulders ePublished: 20 January 2015 Issue Published: 20 January 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...