tbuckley/cabot-search huggingface dataset:
Clinical pathological significance of FDG PET in follicular malignant lymphoma
Authors: I. A. Jaiyesimi
Journal: Journal of Clinical Oncology (2008)

19535 Background: FDG PET is used widely for the staging of lymphoma, but few studies to date have evaluated FDG-PET in follicular lymphoma. We investigated whether FDG PET predicts bone marrow and splenic involvement in follicular lymphoma. To correlate metabolic behavior of follicular lymphoma (FL) with clinical and pathologic grading. Methods: Pre-treatment FDG PET scans of 23 pts (age=59±12) with pathologic diagnosis of FL were analyzed together with Ki67 and FLIPI score (FS). PET scans were obtained 1.5 hr after injection of average of 15 mCi of F-18 FDG with CT attenuation correlation. The glucose was recorded just before PET and the maximal SUVs were measured over biopsy region (BxSUV) and the highest tumor activity of the body (BmSUV). Bone marrow involvement (BMI) was defined by heterogenous marrow FDG uptake with histopathological correlation. Splenic involvement (SI) was defined as abnormal splenic uptake higher than the liver. Discriminant analysis was performed for BMI and SI against the independent variables of BmSUV and BxSUV. Results: Pathologic grading (PG) of FL was significantly correlated with Ki67 (p<0.01). BmSUV, Ki67 and FS were higher in PG III than PG I/II (p=0.032, 0.000 and 0.049). BmSUV and Bx SUV were also significantly correlated (p<0.01) though the means were different (11.5±6.3 vs 7.9±5.1), p<0.0005). BmSUV and Bx SUV classified correctly BMI with similar accuracies of 78% and 74% but BmSUV predicted better than BxSUV in SI at 78% and 65% respectively. There were no such predictions by PG, Ki67 or FS. Conclusions: BmSUV predicts BMI and SI with a higher value in PGIII than PG I/II FL. Clinicians may consider adding FDG PET to the staging workup of FL. No significant financial relationships to disclose.
A randomized clinical trial of the insulin pump vs intensive conventional therapy in diabetic pregnancies
Authors: D. R. Coustan
Journal: JAMA (1986)

Improved perinatal outcome is associated with the prevention of hyperglycemia during pregnancy in diabetic women. To determine whether the method of insulin administration influences the degree of diabetic control obtained, we randomized 22 pregnant diabetic women to intensive conventional insulin therapy (N=11) and insulin pump therapy (N=11). Frequent outpatient visits; home glucose monitoring, at least six times daily; and frequent telephone contact were offered to all subjects. Patients were hospitalized in the inpatient clinical research center each trimester for a 24-hour metabolic profile. There were no differences between the two treatment groups with respect to outpatient mean glucose levels, symptomatic hypoglycemia, or glycosylated hemoglobin levels, or with respect to inpatient mean glucose level, glycemic excursions, chemical hypoglycemia, or hyperglycemia. Excellent metabolic control was achieved with both treatment methods. (<i>JAMA</i>1986;255:631-636)
β-Blockers and Sudden Cardiac Death
Authors: Martin J. Kendall
Journal: Annals of Internal Medicine (1996)

Letters15 August 1996β-Blockers and Sudden Cardiac DeathMartin J. Kendall, MD and Kevin P. Lynch, MDMartin J. Kendall, MDQueen Elizabeth Hospital, Birmingham, United KingdomSearch for more papers by this author and Kevin P. Lynch, MDQueen Elizabeth Hospital, Birmingham, United KingdomSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-4-199608150-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We are grateful for the opportunity to address the concerns that may have arisen from the results of the case–control study of Hoes and colleagues [1], which was published shortly after our review appeared [2]. The conclusion of this study suggested an association between β-blocker therapy and sudden death. Our review advocated the use of β-blockers to reduce the risk for sudden death.Case-control studies are designed to detect possible associations, whereas randomized trials are needed to show the effect of an intervention. In the study of Hoes and colleagues [1], case-patients were probably prescribed a β-blocker more ...References1. Hoes AW, Grobbee DE, Lubsen J, Veld AJ, van der Does E, Hofman A. Diuretics, β-blockers, and the risk for sudden cardiac death in hypertensive patients. Ann Intern Med. 1995; 123:481-7. Google Scholar2. Kendall MJ, Lynch KP, Hjalmarson [42], Kjekshus J. β-blockers and sudden cardiac death. Ann Intern Med. 1995; 123:358-67. Google Scholar3. Holme I. MAPHY and the two arms of HAPPHY [Letter]. JAMA. 1989; 262:3272-4. Google Scholar4. Medical Research Council trial of treatment of hypertension in older adults principal results. MRC Working Party. BMJ. 1992; 304:405-12. Google Scholar5. Teo KK, Yusuf S, Furberg DC. Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction. An overview of results from randomized, controlled trials. JAMA. 1993; 270:1589-95. Google Scholar Author, Article, and Disclosure InformationAuthors: Martin J. Kendall, MD; Kevin P. Lynch, MDAffiliations: Queen Elizabeth Hospital, Birmingham, United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1996Volume 125, Issue 4Page: 349KeywordsDrugsInfarctionMortalityPenicillinRandomized trialsResearch laboratoriesStable coronary artery diseaseSudden cardiac deathVentricular fibrillation ePublished: 15 August 2000 Issue Published: 15 August 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Fungus infection in steroid-treated systemic lupus erythematosus
Authors: V. K. Pillay
Journal: JAMA (1968)

Fungus infection occurred in 12 steroid-treated patients with systemic lupus erythematosus. Candida albicans was the fungus most commonly isolated. Disseminated infection occurred in four patients, and fungus infection contributed to the death of eight. The clinical characteristics of fungus infection include pulmonary symptoms, pyrexia, and progressive deterioration in the clinical state of the patient. Early diagnosis is dependent on persistent search for the infecting fungi. Predisposing factors include the underlying disease, uremia, superficial wounds, and the use of antibiotics, steroids, and immunosuppressive agents. Prevention is dependent on judicious use of antibiotics, vigorous treatment of wounds, and cautious use of steroids.
FREAK LEGISLATION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1408: Diffuse optical spectroscopic imaging reveals regimen-dependent changes in breast tumors throughout neoadjuvant chemotherapy
Authors: Anup Tank, Hannah Peterson, Vivian Pera, Syeda Tabassum, Naomi Ko, Anais Leproux, Bruce Tromberg, Darren Roblyer
Journal: Cancer Research (2019)

Abstract Diffuse Optical Spectroscopic Imaging (DOSI) is a non-invasive near-infrared imaging modality than can provide label-free functional and metabolic information about breast tumors, probing depths up to several centimeters. Previous work has shown that DOSI has prognostic value for pathological response at key timepoints during neoadjuvant (presurgical) chemotherapy (NAC), including baseline, 24 hours after the first infusion, week 1, and at the midpoint of therapy. To date there have been almost no reports on how specific NAC regimens affect the prognostic capability of DOSI. Here we present a large multi-center DOSI dataset consisting of 54 breast tumors and 313 unique measurements taken across three timepoints during NAC: Baseline, week 1, and midpoint of treatment. We will show for the first time that the manifestation of DOSI response parameters (oxyhemoglobin, de-oxyhemoglobin, water, and lipid) is highly dependent on the specific NAC regimen used. Subjects were treated with either a Maximum Tolerated Dose (MTD) regimen, in which a higher dose is administered less frequently, or a Metronomic (MET) regimen, in which a smaller dose is given more frequently. MTD regimen of cytotoxic agents has traditionally been the most effective method to treat breast cancer as it aims to kill the maximum amount of tumor cells before regrowth. MET administration of cytotoxic therapies has shown antiangiogenic properties aiming to limit toxic side effects and drug resistance, while potentially inducing tumor dormancy and immunomodulation. Subjects treated with MTD regimen and also responding to this treatment exhibited an oxyhemoglobin flare in the first day of NAC. In contrast, subjects treated with MET presented only small fluctuations in oxyhemoglobin throughout the first week of NAC. The oxyhemoglobin flare has been theorized to be induced by an inflammatory effect significant for cell death, which could be in response to specifically the MTD regimen and its higher dosing. This study indicates that the specific regimen must be considered when using DOSI for NAC monitoring. It also suggests DOSI may provide biological insight into the regimen-specific mechanisms of action. Citation Format: Anup Tank, Hannah Peterson, Vivian Pera, Syeda Tabassum, Naomi Ko, Anais Leproux, Bruce Tromberg, Darren Roblyer. Diffuse optical spectroscopic imaging reveals regimen-dependent changes in breast tumors throughout neoadjuvant chemotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1408.
The Physiology of the Eye
Authors: Albert M. Potts
Journal: JAMA (1973)

The third edition of this text on visual physiology maintains its place as the most authoritative and most concise exposition of the subject in one volume. Once more the mass of new research since the appearance of the previous edition in 1963 fully justifies this third edition. Once more the results of the most rapidly advancing area of research, this time electrophysiology, are responsible for much of the new material. As with the previous editions, the book will be of value to physicians seeking board certification, psychologists who would like to know some of the bases for their studies, and physiologists who wish a reliable survey of an often neglected portion of their territory. The volume is recommended for all of these and for anyone who requires an up-to-date view of visual physiology.
Pathogenesis And Epidemiology Of Chronic Pancreatitis
Authors: H Sarles
Journal: Annual Review of Medicine (1989)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More
Commentary
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II Study of the Hyper-CVAD Regimen in Combination with Ofatumumab As Frontline Therapy for Adults with CD-20 Positive Acute Lymphoblastic Leukemia (ALL)
Authors: Elias Jabbour, Hagop M. Kantarjian, Deborah A. Thomas, Koji Sasaki, Guillermo Garcia-Manero, Rebecca Garris, Jorge E. Cortes, Tapan M. Kadia, Farhad Ravandi, Srdan Verstovsek, Susan O'Brien
Journal: Blood (2014)
A chamber pot and Bible.
Authors: Barbara Holland, Consultant Neonatologist, C Wardrop
Journal: BMJ (1985)

weeks' supportive care.Splenectomy may very occasionally become necessary after lapse to chronic haemolysis in three to six months.Pneumococcal vaccination and oral penicillin minimise but do not abolish the infective hazards of hyposplenism.2 They found, as did others,'3 that autoimmune haemolysis in childhood is only rarely associated with underlying disease such as systemic lupus erythematosus.This contrasts with experience in adults, in whom autoimmune haemolytic anaemia may be symptomatic of collagen diseases such as systemic lupus erythematosus or of lymphoma.14The enigmas of the pathogenesis of autoantibody formation to red cells will be important to unravel.This diathesis may be partly genetically determined.'5Recent progress has been made in the understanding and management of the haemolytic-uraemic syndrome, an uncommon but dramatic and life threatening emergency.'6Its pathogenesis is now thought in some cases to hinge on imbalance between prostacyclin and thromboxane and on platelet-vascular interactions and endothelial damage.With greater understanding of the pathological basis of the haemolytic-uraemic syndrome rational, specific manage- ment may soon become available, at least in some cases.Evaluation of any proposed specific treatments would have to be adequately controlled or doubts will remain about their value, as in the recent report of management of epidemic and sporadic haemolytic-uraemic syndrome using vitamin E.'7 Improvements in recent years in supportive care, particularly for renal failure, have improved the prognosis- especially of the sporadic form of the syndrome.The common ground in management of these haemolytic anaemias acquired in childhood, whether caused by autoantibody formation or associated with metabolic and microvascular damage, is recognition of the importance of supportive, symptomatic care.If the child's anaemia can be "tided over" for a week or two-and any associated disorder such as renal failure effectively managed-the only treatment needed may be red cell transfusions.More aggressive "haematological" treatments such as steroids, immuno- suppression, or even splenectomy for immune mediated haemolysis are indicated only with lapse over several weeks or months to chronic, severe autoimmune haemolytic anaemia.
A Treatise on Appendicitis
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: T. MOENCH
Journal: JNCI Journal of the National Cancer Institute (1991)

BOOK REVIEWS Get access Retrovirus Biology and Human Disease . Robert C. Gallo , Flossie Wong-Staal , eds. New York : Marcel Dekker , 1990 , 432 pp. $99.75. THOMAS MOENCH THOMAS MOENCH Johns Hopkins University, School of MedicineBaltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 8, 17 April 1991, Page 576, https://doi.org/10.1093/jnci/83.8.576 Published: 17 April 1991
Treatment of the Mentally Subnormal
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resource Use, Patient Education, and Improving the Quality of Health Care—Reply
Authors: J. Frank Wharam
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adult Immunizations
Authors: Pierce Gardner
Journal: Annals of Internal Medicine (1996)

New vaccines have been licensed for hepatitis A, varicella, and typhoid. This paper reviews these vaccines and their recommended uses in adults. Special attention is given to a new national policy establishing age 50 years as a time for review of preventive health measures with emphasis on evaluating risk factors that indicate a need for pneumococcal vaccine and the initiation of annual influenza immunization.
Metabolism of Heterogenic Hemoglobins: Fe59 Incorporation in Sickle Cell Trait
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEW MEXICO FOR CONSUMPTIVES.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal