tbuckley/cabot-search huggingface dataset:
Abstract 4511: Prostate cancer-specific enrichment of <i>TP53</i> missense mutations elicits differential, context-dependent biochemical and biologic outcomes
Authors: Jennifer J. McCann, Irina Vasilevskaya, Neermala PoudelNeupane, Jeffry Dean, Amy Mandigo, Renee De Leeuw, Chris McNair, Matthew Schiewer, Karen Knudsen
Journal: Cancer Research (2019)

Abstract Prostatic adenocarcinoma (PCa) remains the second leading cause of cancer death in men in the United States. While organ-confined disease can be successfully treated with surgery or radiation, patients with advanced disease undergo androgen deprivation therapy (ADT), which targets the androgen receptor (AR) signaling axis. This approach effectively treats the disease as PCa cells are exquisitely dependent on AR signaling for proliferation and survival. Unfortunately, cancer progression resumes after 2-3 years and results in a lethal stage of disease, termed castration-resistant prostate cancer (CRPC). While PCa typically demonstrates low overall mutational burden, TP53 is frequently mutated in both primary and advanced disease. These mutations are most commonly missense mutations in the DNA binding domain of TP53, and can occur in the presence or absence of a wildtype TP53 allele. Interestingly, specific enrichment of certain TP53 mutations frequently occurs in PCa when compared to other cancers, and similar to many other cancers, these mutations occur in the presence or absence of wildtype TP53. Using hormone therapy sensitive and CRPC cells, a panel of cell lines was generated to model these mutations in the presence or absence of wildtype TP53 expression. Defining the TP53 missense mutant-sensitive transcriptomes demonstrated context dependent, differential gene expression between TP53 missense mutants, related to the expression of wildtype TP53 in those cells. This also applied to cistrome analysis, illustrating an expansion of the p53 cistrome upon expression of mutant TP53. Furthermore, expression of p53 mutants also elicited context dependent effects on canonical p53 functions, thereby modulating distinct, downstream biological outcomes. Consequently, these data define the distinct and context dependent roles that mutant TP53 plays in PCa progression. Citation Format: Jennifer J. McCann, Irina Vasilevskaya, Neermala PoudelNeupane, Jeffry Dean, Amy Mandigo, Renee De Leeuw, Chris McNair, Matthew Schiewer, Karen Knudsen. Prostate cancer-specific enrichment of TP53 missense mutations elicits differential, context-dependent biochemical and biologic outcomes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4511.
Transfusion medicine faces time of major 'challenges and changes'
Authors: A. A. Skolnick
Journal: JAMA (1992)

EVIDENCE exists for hazards of blood transfusions that—while not as widely recognized as the risk of transmitting human immunodeficiency virus and hepatitis infections—may, potentially at least, be just as deadly. Some of these suspected risks were discussed at the conference entitled "Challenges and Changes in Transfusion Medicine," recently held by the American Association of Blood Banks and the National Heart, Lung, and Blood Institute in Bethesda, Md. (Please see accompanying article.) <h3>Immunosuppressive Aspect?</h3> There is growing evidence that homologous blood transfusions are immunosuppressive, says Paul Waymack, MD, associate professor of surgery, University of Texas Medical Branch, Galveston. Numerous animal studies have supported clinical observations that homologous blood transfusions may broadly impair the patient's immune system, says Waymack. He adds: "Allogeneic transfusions enhance tumor growth in animal studies and are correlated with decreased survival in multiple retrospective human oncology studies. Allogeneic transfusions also impair resistance to bacterial infections in animal models
The FTA-ABS test in dark-field-positive primary syphilis
Authors: W. C. Duncan
Journal: JAMA (1974)

The fluorescent treponemal antibody absorption (FTA-ABS) test was performed in 77 consecutive patients with dark-field-positive primary syphilis. The test was reactive in 70 of the 77 patients (91%). These results make this serologic test extremely valuable in the diagnosis of syphilis at a time when this disease is on the increase, and the number of well-trained darkfield technicians is on the wane. (<i>JAMA</i>228:859-860, 1974)
PSYCHOANALYSIS
Authors: JAMES H. MEANS
Journal: Annals of Internal Medicine (1934)

Editorials1 March 1934PSYCHOANALYSISJAMES H. MEANSJAMES H. MEANSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-9-1146_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf what use, in the treatment of the patient, is psychoanalysis? This is a question which must have occurred to many a physician. Nor can he readily find a dependable answer. It is by results, especially end-results, that we should judge the merit of any form of therapy. Because of scarcity of such information in the case of therapeutic psychoanalysis, physicians have assumed an attitude toward that procedure all the way from open hostility to wild enthusiasm, with hostility or indifference predominating.That many physicians should look askance at psychoanalysis is due in part to the seeming bizarreness of some...* KESSELHYMAN LHT: The value of psychoanalysis as a therapeutic procedure, Jr. Am. Med. Assoc., 1933, ci, 1612. CrossrefGoogle Scholar† STEKEL W: The future of psychoanalysis (translation by L. S. LONDON), Psychoanalytic Rev., 1933, xx, 327. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1934Volume 7, Issue 9Page: 1146-1148KeywordsPatientsPsychoanalysis ePublished: 1 December 2008 Issue Published: 1 March 1934 PDF downloadLoading ...
HOSPITAL SERVICE ACCORDING TO TYPES OF SERVICE AND AGENCIES CONCERNED
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vulnerable Plaque
Authors: Lanfranco de' Clari
Journal: Annals of Internal Medicine (1999)

Letters7 September 1999Vulnerable PlaqueLanfranco de' Clari, MDLanfranco de' Clari, MDClinica al Parco; CH-6900 Lugano, Switzerland (de' Clari)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-5-199909070-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their excellent review, Kullo and colleagues did not mention colchicine, a potent agent that precisely and specifically inhibits the very protagonists of plaque formation—destabilization and rupture. Colchicine binds to β-tubulin and inhibits the proliferation of microtubules and microtubule-dependent processes during cell activation. This affects not only lymphocyte proliferation and the migration, diapedesis, and phagocytic activity of granulocytes and macrophages but also the synthesis, intracellular transport, and secretion of cytokines (2). Colchicine decreases tumor necrosis factor and interleukin-2 secretion, downregulates tumor necrosis factor receptors on macrophages, and deactivates these receptors' secretion of proteases and other mediators. All ...References1. Kullo IJ, Edwards WD, Schwartz RS. Vulnerable plaque: pathobiology and clinical implications. Ann Intern Med. 1998;129:1050-60. LinkGoogle Scholar2. Kershenobich D, Rojkind M, Quiroga A, Alcocer Varela J. Effect of colchicine on lymphocyte and monocyte function and its relation to fibroblast proliferation in primary biliary cirrhosis. Hepatology. 1989;11:205-9. CrossrefGoogle Scholar3. Frenette PS, Wagner DD. Adhesion molecules—part II: blood vessels and blood cells. N Engl J Med. 1996;335:44-9. CrossrefGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Clinica al Parco; CH-6900 Lugano, Switzerland (de' Clari) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoVulnerable Plaque: Pathobiology and Clinical Implications Iftikhar J. Kullo , William D. Edwards , and Robert S. Schwartz Vulnerable Plaque Iftikhar J. Kullo , William D. Edwards , and Robert S. Schwartz Vulnerable Plaque Guha Krishnaswamy , David S. Chi , and Jim Kelley Vulnerable Plaque James C. Doherty and Marvin A. McMillen Metrics 7 September 1999Volume 131, Issue 5Page: 393KeywordsAnticoagulantsColchicineCytokinesImmunosuppressivesLymphocytesNeutrophilsProteasesToxicityTumor necrosis factorUnstable angina Issue Published: 7 September 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Reproductive Effects in Birds Exposed to Pesticides and Industrial Chemicals
Authors: D. Michael Fry
Journal: Environmental Health Perspectives (1995)

Environmental contamination by agricultural chemicals and industrial waste disposal results in adverse effects on reproduction of exposed birds.The diversity of pollutants results in physiological effects at several levels, including direct effects on breeding adults as well as developmental effects on embryos.The effects on embryos include mortality or reduced hatchability, failure of chicks to thrive (wasting syndrome), and teratological effects producing skeletal abnormalities and impaired differentiation of the reproductive and nervous systems through mechanisms of hormonal mimicking of estrogens.The range of chemical effects on adult birds covers acute mortality, sublethal stress, reduced fertility, suppression of egg formation, eggshell thinning, and impaired incubation and chick rearing behaviors.The types of pollutants shown to cause reproductive effects include organochlorine pesticides and industrial pollutants, organophosphate pesticides, petroleum hydrocarbons, heavy metals, and in a fewer number of reports, herbicides, and fungicides.o,p'-DDT, polychlorinated biphenyls (PCBs), and mixtures of organochlorines have been identified as environmental estrogens affecting populations of gulls breeding in polluted "hot spots" in southern California, the Great Lakes, and Puget Sound.Estrogenic organochlorines represent an important class of toxicants to birds because differentiation of the avian reproductive system is estrogen dependent.
Analysis of Foreign Journals
Journal: BMJ (1841)

AN(AL?MS1 P POftu?O IOUALS.traction, synchronous with the pulse in the caro- tids, and the first or ventricular sound.2. Dila- tation, duringwhich the heart "was much enlarged by as active a force as that of contraction, (it was dilated even when by pressure we attempted to prevent it); whilst in the fingers, it gave a sensa- tion as if it was first forcibly enlarged, and then a fluid rushed in, with one wave, communicating the feeling of a thrill.The dilatation was synchronous with the second or loud sound, but it appeared to continue after it."3.During the systole, a third or dowvnward movement of the whole tumor was observed, and this took place regularly and with considerable force."From the loud noise, or that caused by the reaction of the arteries on the blood expanding the semilunar valves, to the duller or that called ventri- cular, the space of time appeared to be about onehalf of the whole timpe of the heart's action.The period of rest was all but imperceptible; indeed, it appeared inseparable from the dilatation and filling of the ventricles."vinally, Dr. O'Bryen remarks, that no sound was produced by the contraction of the left ven- tricle, the sounds appearing to proceed from the neighbourhood of the valves.-lDS.]
The Sheffield Grinders
Authors: J. C. Hall
Journal: BMJ (1857)

tected by a single bandage, which should be adapted to the surface of the limb with the most perfect accuracy.Reverses should be avoided, as they form ridges, likely to irritate.As the sole object of this first bandage is to cover the skin per- fectly, a little practice will teach the best mode of applyina it so as to secure the desideratum without chance of mis- chief.The plastered bandage is next applied, with the same precaution as to accurate evenness; but, as a preparatory
Deoxycholate and cholate modulate the source of cholesterol substrate for bile acid synthesis in the rat*1
Authors: J SCHEIBNER
Journal: Hepatology (1995)

In the current study, the role of the supply of preformed and newly synthesized cholesterol for the feedback control of the synthesis of different bile acids and the secretion of biliary cholesterol was investigated. To define these cholesterol fluxes and the possibility of a different modulation by bile acids with different suppressive capacities, a continuous labeling with tritiated water was used in rats with an extracorporeal bile duct receiving intraduodenal infusions of taurocholate or taurocholate plus deoxycholate. After bile acid pool depletion (6 to 9 hours) total muricholate, cholate, and chenodeoxycholate synthesis was variably increased (24% to 93%) during an infusion of 304 μmol taurocholate/kg per hour. The increase in bile acid synthesis and biliary cholesterol output was predominantly due to the utilization of preformed (unlabeled) cholesterol. The addition of 52 μmol/kg per hour of deoxycholate to 258 μmol/kg per hour of taurocholate had a comparable effect. In the late period (30 to 54 hours), the taurocholate infusion had little impact on total muricholate and chenodeoxycholate synthesis but caused by a significant increase of the proportion from preformed cholesterol. Both total cholate production and its synthesis from de novo (labeled) cholesterol was inhibited by 30% (P < .05) and 64% (P < .01), respectively. The secretion rate of total and de novo biliary cholesterol was higher (65% and 72%; P < .01) compared with controls. In comparison, the combined bile acid infusion led to a further increase of total muricholate synthesis (P < .05), which was again due to an enhanced synthesis from preformed cholesterol (P < .001). Similar changes were observed in chenodeoxycholate. The more pronounced suppression of total cholate synthesis by 81% (P < .05) was due to a diminished cholate synthesis from both de novo cholesterol by 72% (P < .001) and preformed cholesterol by 91% (P > .05). We conclude that the modulation of the synthesis of the various primary bile acids in the rat differs and feedback regulation of cholate synthesis by taurocholate and deoxycholate is mediated by different mechanisms of control, including inhibition of cholesterol 7α-hydroxylase, HMG-CoA reductase, and uptake of lipoprotein cholesterol.
Manuscripts Approved for JNCI, January 10 to February 10, 1963
Journal: JNCI Journal of the National Cancer Institute (1963)

Manuscripts Approved for JNCI, January 10 to February 10, 1963 Get access JNCI: Journal of the National Cancer Institute, Volume 30, Issue 3, March 1963, Page 643, https://doi.org/10.1093/jnci/30.3.643 Published: 01 March 1963
The Machine
Authors: Don Lewis
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Note di immunoterapia in otorinolaringologia.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinogenicity Bioassays of Vinyl Chloride Monomer: A Model of Risk Assessment on an Experimental Basis
Authors: Cesare Maltoni, Giuseppe Lefemine, Adriano Ciliberti, Giuliano Cotti, Donata Carretti
Journal: Environmental Health Perspectives (1981)

Data are presented regarding the final results of the Bentivoglio (Bologna) project on long-term carcinogenicity bioassays of vinyl chloride (VC). The experimental project studied the effects of the monomer, administered by different routes, concentrations and schedules of treatment, to animals (near 7000) of different species, strains, sex and age. To our knowledge this is the largest experimental carcinogenicity study performed on a single compound by a single institution. The results indicate that VC is a multipotential carcinogen, affecting a variety of organs and tissues. In the experimental conditions studied, the neoplastic effects of the monomer were also detected at low doses. The experimental and biological factors greatly affect the neoplastic response to VC. Long-term carcinogenicity bioassays are, at present, a unique tool for the identification and quantification of environmental and occupational risks. Precise and highly standardized experimental procedures are needed to obtain data for risk assessment.
Second International Conference on Malignant Lymphoma
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Second International Conference on Malignant Lymphoma Get access JNCI: Journal of the National Cancer Institute, Volume 70, Issue 5, May 1983, Page 988, https://doi.org/10.1093/jnci/70.5.988-b Published: 01 May 1983
TCT-43 A Prospective Randomized Multicenter Study to Assess the Safety and Effectiveness of the Orsiro Sirolimus-Eluting Stent in the Treatment of Subjects With Up to 2 De Novo Coronary Artery Lesions—BIOFLOW IV: 4-Year Clinical Results
Authors: Ton Slagboom, Ralph Toelg, Bernhard Witzenbichler, Michael Haude, Rafael Jose Ruiz-Salmeron, Adam Witkowski, Ron Waksman, Shigeru Saito
Journal: Journal of the American College of Cardiology (2019)
Mesenteric adenitis.
Authors: J. G. Howie
Journal: BMJ (1969)

BMDICH Jouse 449 from the casualty department those patients whose self-poisoning episode was trivial in the poisoning sense.It is realized that to put the burden of psychiatric assessment in 'such cases on a busy casualty officer, often with little psychiatric training, is grossly unfair on the doctor and possibly lethal for the patient, whose initial attempt at suicide failed from lack of medical knowledge rather than from mental illness, which may be severe.To have a psychiatric unit in a general hospital must be very useful, Unfortunately this is not the case in Sunderland.-I am, etc.,
Fetal Surgery
Authors: Karlis Adamsons
Journal: New England Journal of Medicine (1966)

UNTIL a few years ago the treatment of the intrauterine patient was limited to chemotherapy of a few infectious diseases and to hormonal supplementation in certain endocrine disorders of the mother. In neither circumstance was the fetus considered as the principal beneficiary, and the therapeutic effort was predominantly directed toward the cure of the mother. It appears that the physician had accepted the futility of any effort aimed at altering the natural history of prenatal disorders. The reasons for this self-imposed restraint are not immediately apparent, and one wonders why the pragmatically inclined obstetrician has not derived more encouragement from . . .
SIMIAN VIRUS 40 AND POLIO VACCINE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal