tbuckley/cabot-search huggingface dataset:
The Eclipse of a Mind
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the NIH: Changes in biological rhythms may cause sleep disorders
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Histology of the More Important Human Endocrine Organs at Various Ages.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proc Soc Exper Biology &amp;amp; Medicine, New York
Journal: JAMA (1966)

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"Health Devices"
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1971)

IN the field of medicine, a new monthly periodical seeking the usual objective of solvent success, might seem to be off to a dubious start if it (1) saddled itself with a $250-a-year subscription price, (2) requested editorially that subscribers refrain from sharing its pages, and (3) printed text that bluntly rated some products of big business as unacceptable or even hazardous. Yet this is exactly what a new publication called Health Devices has done. Its sponsors are convinced that hospital administration needs to be given, and will pay for, objective information concerning the 5000-odd devices that doctors and ancillary . . .
Peripartum Cardiomyopathy
Authors: Sharon C. Reimold, John D. Rutherford
Journal: New England Journal of Medicine (2001)

Peripartum cardiomyopathy is a poorly understood condition whose incidence in the United States is 1 per 3000 to 4000 live births.1 Previous descriptions of the disorder were based on a vague definition derived from a heterogeneous group of patients,2 but in 1997, the participants in a National Heart, Lung, and Blood Institute (NHLBI) workshop agreed on a standardized definition.3 Peripartum cardiomyopathy was defined clinically as the onset of cardiac failure with no identifiable cause in the last month of pregnancy or within five months after delivery, in the absence of heart disease before the last month of pregnancy. The finding . . .
The Lariat for Left Atrial Appendage Closure: Rehash of Known Literature or a True Analysis?
Authors: Hosakote Nagaraj, David Wilber, Dhanunjaya R. Lakkireddy
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
CLIMATE IN THE TREATMENT OF TUBERCULOSIS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biotransformation of Nitric Oxide
Authors: Katsumi Yoshida, Kazuo Kasama
Journal: Environmental Health Perspectives (1987)

Previous investigations into the health effects of nitrogen oxides (NOx) have mostly been conducted with special reference to nitrogen dioxide (NO2) and its direct effects on the respiratory system, while the study of nitric oxide (NO) has been disregarded. We carried out a study on NO by exposing rats and mice to 15NO or administering 15N-nitrite and 15N-nitrate to these animals by IP injection in order to elucidate the metabolic fate of NO. The results of our study and previous findings led us to assume that the major metabolic path of inhaled NO is as follows: inhaled NO reacts with hemoglobin, forming nitrosyl-hemoglobin (NOHb), and from NOHb, nitrite (NO2-) and nitrate (NO3-) are generated. Major quantities of NO3- are discharged into the urine and a certain amount is discharged into the oral cavity through the salivary glands and transformed to NO2-. Part of this NO2- is converted to N2 gas in the stomach. Nitrate in the intestine is partly reduced to ammonia (NH3) through NO2-, reabsorbed into the body, and converted to urea. Most of the metabolites of inhaled NO are excreted rapidly from the body within 48 hr.
Boxing Day
Authors: Peter R. Killeen
Journal: Behavioral and Brain Sciences (2000)

A convincing case is made for the importance of conditioning in social interaction, but more than Pavlovian conditioning is involved: UR (unconditioned response) modification, imprinting, Skinnerian conditioning, and other forms of behavior modification are adduced as Pavlovian. Beyond its value as an icon, control theory is not brought to bear in an informative fashion on these phenomena.
Clinical Tests in Aquatic Toxicology: State of the Art
Authors: Paul M. Mehrle, Foster L. Mayer
Journal: Environmental Health Perspectives (1980)

Hazard assessment of chemicals to aquatic organisms involves the use of many toxicity tests. Acute toxicity tests, embryo-larval toxicity tests, and chronic toxicity tests that measure survival, growth, and reproductive effects now provide the most relative utility for evaluation of potential chemical hazards to aquatic life. Physiological, biochemical, and histological measurements have a low relative utility as diagnostic tests in aquatic toxicology because it is not yet possible to relate changes in these sublethal responses to adverse environmental impacts. The problem of interpreting the toxicological significance of chemical-induced changes in biochemical and physiological mechanisms is twofold: (1) the understanding of physiological and biochemical regulatory mechanisms in fish is limited; and (2) parallel changes in these mechanisms are difficult to correlate with toxicant exposure and impaired ability of fish to survive. To overcome this problem, more physiological and biochemical research must be conducted in conjunction with toxicity studies that measure important whole-animal responses. Toxicant-induced biochemical and physiological responses must be correlated unequivocally with responses related to reproduction, growth and development, survival, or fish health if pertinent diagnostic tests are to be developed for use in aquatic toxicology. The use of diagnostic tests in hazard assessment procedures can decrease the time required for safety evaluation of chemicals, define no-effect exposure concentrations more adequately, and provide a better understanding of the mode of action of chemicals. Considerations for improving the status of the "state of the art" of diagnostic or clinical tests in aquatic toxicology are discussed.
Recurrence
Authors: Andy Young
Journal: JAMA (2020)

Because I'm a poet I try to make music of her diagnosis: scan the adonics of glioblastoma, terminal cancer, clinical trials.No music in this diagnosis: scans show the tumor bed ringed with chthonic glioblastoma cells.Radiation and chemo just slow what the brain tumor will bring.The cures break down healthy cells, too: radiated, poisoned, she tries to pop back up again between these cures that break her down.A new tumor emerges in the parietal, popping back up again like a nightmare game of whack-a-mole.A new tumor emerges in the parietal like a ghost of its sibling from the temporal, like a nightmare game of whack-a-mole.To hell with games and similes.Siblings, parents: future ghosts; all's temporal.There's no meter in that music, To hell with games and similes.There is no comfort in cureless verse.There's no meter in this music, in the adonics of glioblastoma, no comfort in this cureless verse that as a poet I can't help but make.
Scintigraphic evaluation of patients with suspected pulmonary thromboembolism
Authors: D. A. Turner
Journal: JAMA (1987)

<h3>In Reply.—</h3> Drs Howard and Young are, of course, entirely right about my muddled corn terminology. The error is all the more embarrassing because my roots<i>are</i>in loam: I am a native of Nebraska. Although I did not grow up on a farm, I certainly know the difference between corn husks, ears of corn, and corn cobs. My family's discovery that I was capable of such an elementary goof will only confirm their view that my education was seriously marred by my neglect of Cornhusker football games and other patriotically instructive rituals. Fortunately, my mother has reassured me that I will still be allowed to come home for Christmas. One can't argue with Dr Young's suggestion that the elderly man in the painting could be the little boy's father: this is not a portrait of real individuals, after all. That we who are several generations removed from 19th-century rural
DR. OGSTON'S CRITICISMS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiologie des Vaisseaux de la Base du Cœur.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract LB-260: CCR5 antagonists block basal breast cancer and prostate cancer metastasis in vivo.
Authors: Richard G. Pestell
Journal: Cancer Research (2013)

Abstract The identification of new therapeutic targets and treatments to reduce tumor metastasis homing requires alternative interrogation approaches. Interrogation of microarray analysis of 2,254 human breast cancers demonstrated increased expression of CCL5 and its receptor CCR5, but not CCR3, in the basal and HER-2 genetic subtypes of breast cancer. Genome wide interrogation of pathways activated in patient normal breast vs. tumor identified upregulation of a CCR5 signaling module. Human breast cancer cell lines expressed CCR5 by flow cytometry, and displayed a functional response to CCL5 by calcium mobilization assays and invasion assays. Using isogenic oncogene transformed breast and prostate cancer cell lines, we show oncogene transformation induces CCR5 expression and that the subpopulation of cells that express functional CCR5 display increased invasiveness. CCR5 promoted metastasis homing in vivo. The CCR5 antagonists Maraviroc and Vicriviroc, developed to block CCR5 HIV co-receptor function, reduced in vitro invasion of basal breast cancer and prostate cancer cell lines without affecting cell proliferation or viability. In a series of preclinical mouse models, Maraviroc decreased breast pulmonary metastasis. The isogenic prostate cancer cell lines metastasized to bones in immune-competent mice representing an ideal model for testing anti-metastasis therapies. Maraviroc and Vicriviroc reduced prostate cancer metastasis to brain, bones and lungs. Our findings provide evidence for a key role of CCL5/CCR5 in the metastasis of basal breast cancer and prostate cancer cell lines, and suggest that CCR5 antagonists may be used as an adjuvant therapy to reduce the risk of metastasis in patients with the basal breast cancer subtype and prostate cancer. Citation Format: Richard G. Pestell. CCR5 antagonists block basal breast cancer and prostate cancer metastasis in vivo. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-260. doi:10.1158/1538-7445.AM2013-LB-260
PHRENICECTOMY FORCEPS
Authors: Oscar S. Proctor
Journal: JAMA (1928)

These forceps were designed to facilitate the extraction in phrenicectomy, or exeresis of the phrenic nerve. I had previously had trouble with the ordinary hemostat, because of the nerve slipping over its end, particularly when the former was under tension. Not infrequently, several turns of the nerve would slide off and, when rewound, the nerve seemed more apt to break. To obviate this difficulty I had these forceps made. The nerve is caught, as shown in the illustration, just proximal to the projection, or button, on it. The short end of the forceps projecting beyond can be placed on a hemostat or in a curved retractor, which steadies the instrument and makes the winding smooth and even. I have used these forceps for some months with much satisfaction. Medical and Dental Building.
Phenobarbital modulates the type of cell death by rat hepatocytes during deprivation of serum in vitro*1
Authors: C CHIAO
Journal: Hepatology (1995)

An immortal line of chemically altered rat hepatocytes was used to study the effects of the liver tumor promoter, phenobarbital (PB), on hepatocyte growth and viability in vitro. When the serum concentration in medium was changed from 10% to 0.5%, cell proliferation decreased and hepatocytes died. Death of the hepatocytes occurred after 2 days in low-serum medium. PB appeared to control the type of cell death that occurred. In the absence of PB in low-serum medium, most dead cells had morphological changes that are characteristic of necrosis as determined by both light and electron microscopy. In the presence of PB, the dead cells had alterations typical of apoptosis. Biochemical features of cell death in lowserum medium were also analyzed. DNA isolated from cells in low serum with PB showed nucleosome-length fragments after gel electrophoresis, whereas DNA from cells in low serum without PB appeared as randomly degraded fragments. Although proliferation of hepatocytes in low-serum decreased by 75%, the appearance of apoptosis in the presence of PB was associated with increased expression of the c-myc gene. Based on these observations, we conclude that PB can modulate the type of cell death that occurs after serum deprivation in this line of immortal rat hepatocytes. PB seemed to prevent necrotic cell death in low serum, and cells died through a gene-directed pathway of apoptosis.
Reduction of Bacteriuria and Pyuria Using Cranberry Juice-Reply
Authors: Jerry Avorn
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr Hamilton-Miller raises an interesting mechanistic question. However, similarly high concentrations of quinic acid were added to the placebo beverage to mimic the taste of cranberries, making this explanation less likely. Moreover, benzoate is very widespread as a preservative in common foods, occurring in higher concentrations in soft drinks (170 to 420 ppm) than in standard cranberry-based beverages (40 to 50 ppm). The pK<sub>a</sub>of all these organic acids is about 4, so they would exist in a predominantly ionized state at the pH of urine. If the effect of cranberry juice on bacteriuria is real, a likelier mechanism may be the inhibition of bacterial adherence to the mucosal surface.<sup>1</sup> We agree with Dr Goodfriend that catheterized urine specimens represent a criterion standard. However, by using careful technique, we succeeded in obtaining samples without bacteriuria (using the standard definition) in about three fourths of all samples,