tbuckley/cabot-search huggingface dataset:
Gastric hypochlorhydria and achlorhydria in older adults
Authors: R. M. Russell
Journal: JAMA (1997)

The studies by Dr Russell and colleagues have added to our appreciation that achlorhydria, resulting from either omeprazole administration or atrophic gastritis, can cause malabsorption of protein-bound vitamin B<sub>12</sub>.<sup>1</sup>Though we did not determine absorption or levels of vitamin B<sub>12</sub>, we do not share his view that our data show one third of elderly Americans to be at risk of malabsorption of food-bound vitamin B<sub>12</sub>. Six (2%) of our 248 subjects were receiving vitamin B<sub>12</sub>injections, 4 of whom had low basal acidity by the resin test (urine quinine &lt;90 pg in 2 hours) and severe atrophic gastritis (serum pepsinogen [PG] I &lt;20 pg/L). In the other 2 subjects, both parameters were normal. Twenty-two (9%) of 243 elderly subjects had PG I/PG II ratios less than 2.9, indicating atrophic gastritis. None was anemic. Those who had severe atrophic gastritis (PG I ≤20 pg/L) (n=11) also
From the Centers for Disease Control and Prevention. Bacillus cereus food poisoning associated with fried rice at two child day care centers--Virginia, 1993
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EFFECTS OF MYOCARDIAL INSUFFICIENCY
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anniversary Meeting of the British Medical Association
Journal: BMJ (1840)

took the chair at seven o'clock P. m.The CHAIRMAN, in opening the business, said, that they were assembled on the very apot where, four years ago, this assoiation received its final impress.At that time it was predicted that it would not be of long continuance; but those predictions had proved untrue.None of the cororators then attended the meeting, though they were aLware of its being held, to oppose any of the propositions ahid before it.One gentleman, who attended from a liberal insttution, was so fnrihtened with the picture which it was \ne eAsaryto dra of the corporations, that he left the room, ad had never since returned.(Laughter.)They had now arrived at an important crisis.Having aroused the pro- fession from the apathy into which it had sunk, its present ea and energy must be tumed to some good account.theirs was the cause of reason, ofjustice, and of the public a therefore it required none of the aids of rhetoric i advrocate it.Many of the objects which the association Iad in view at its foundation had been fully realized.A dege of unity now existed in the profession which never prevailed before.The benevolent fund had been favourably progiessing.(Cheers.)One obect to be steadily kept in view, ras the enlightenment of the public mind.the battle about to be fought was emphatcall that of the public.
Domestic violence victims in the emergency department. New findings
Authors: W. G. Goldberg
Journal: JAMA (1984)

Four hundred ninety-two male and female patients from a general hospital emergency department were surveyed to elicit information on the extent and nature of domestic violence among this population. The patient's emergency department medical records were also reviewed. Twenty-two percent of the patients identified themselves on the survey as domestic violence victims. New findings in the areas of medical classification, nature of the abusive relationship, and patients' perceived treatment needs contribute to refining the battered spouse syndrome and are helpful in planning therapeutic intervention. The authors conclude that domestic violence victims should be identified and offered assistance while in the emergency department and outline a crisis intervention plan. (<i>JAMA</i>1984;251:3259-3264)
Syphilis Screening
Authors: M. J. Friedrich
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3420: Effects on Myocardial Perfusion at 3 and 15 Months in Recanalized Chronic Total Occlusions - Randomized Comparison of Blood-Derived Progenitor Cells and Inactive Serum
Authors: Holger Thiele, Andreas Schuster, Sandra Erbs, Volker Adams, Karsten Lenk, Axel Linke, Rainer Hambrecht, Gerhard Schuler
Journal: Circulation (2007)

Background: MRI is an excellent diagnostic tool for serial assessment of changes in myocardial perfusion, left ventricular function, and infarct size. In chronic total occlusions (CTO) the effects of recanalization on perfusion and function are contradictory and might depend primarily on viability. Circulating progenitor cells (CPC) injected intracoronarily after successful CTO recanalization might improve perfusion and function. Methods and results: Twenty-eight patients with reperfused CTO were randomized to either CPC’s or inactive serum (control), which were infused into the target vessel. First-pass myocardial perfusion MRI at rest and stress using adenosine at standard dose revealed a significant improvement of the myocardial perfusion reserve index (MPRI) in the affected segments. The baseline MPRI in affected segments was 1.50±0.17 in CPC versus 1.46±0.16 in control (p=0.62). In CPC the MPRI improved to 1.76±0.16 (p&lt;0.001) at 3 and 1.82±0.20 (p&lt;0.001) at 15 months; in control the change was 1.58±0.10 (p=0.01) at 3 and 1.61±0.08 (p=0.004) at 15 months follow-up. However, the MPRI recovery was significantly better in CPC as compared to control at 3 (p=0.004) and 15 months (p=0.005). In remote myocardium the MPRI was 1.70±0.30 and 1.69±0.25 (p&lt;0.01 versus affected segments), respectively. At follow-up there was no significant improvement for both groups. The change in MPRI at 3 and 15 months was correlated with a change in overall infarct size for CPC (3 months: r=−0.68, p&lt;0.02; 15 months: r=−0.81, p=0.001), whereas in control there was no correlation (r=−0.38, p=0.26; 15 months: r=−0.21, p=0.56). Infarct transmurality influenced MPRI improvement at follow-up. CPC patients had a trend towards more improved segments in particular those with higher transmurality (p=0.06). Conclusions: Analysis of serial contrast-enhanced MRI suggests that intracoronary application of CPC post recanalization of CTO is associated with improved myocardial perfusion and subsequent improved recovery of left ventricular function as compared to a control group at mid- and long-term follow-up. Further investigations of the pathophysiological CPC effects on macro- and microvascular function are required.
Otolaryngology—Head and Neck Surgery
Authors: William D. Clark
Journal: JAMA (1987)

<i>Otolaryngology—Head and Neck Surgery</i>is the latest attempt to offer comprehensive coverage of the specialty under one title. One could question the need for a new start on an old problem rather than revised editions of previous undertakings. The four-volume set is edited by Charles W. Cummings, MD, chairman of the Department of Otolaryngology at the University of Washington. Each volume has its own editor as well. Volume 1,<i>General Face, Nose, Paranasal Sinuses</i>, is edited by Charles J. Krause, MD, chairman of otolaryngology at the University of Michigan; volume 2,<i>Salivary Glands, Oral Cavity/Oropharynx, Neck</i>, by David E. Schuller, MD, chairman of otolaryngology at Ohio State University; volume 3,<i>Larynx/Hypopharynx, Trachea/Esophagus, Thyroid/Parathyroid</i>, by John M. Fredrickson, MD, professor and head of otolaryngology at Washington University School of Medicine, St Louis; and volume 4,<i>Ear and Skull Base</i>, by Lee Harker, MD, professor and vice chairman of otolaryngology at the
Erratum: Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ
Authors: Takashi Matsuda, Takeshi Y Hiyama, Fumio Niimura, Taiji Matsusaka, Akiyoshi Fukamizu, Kenta Kobayashi, Kazuto Kobayashi, Masaharu Noda
Journal: Nature Neuroscience (2017)
Proceedings of the British Thoracic Society
Authors: R Wilson, P Jones, L Osman, J Douglas, C Bredin, S Donnelly, C Robertson, T Parke, D Steedman, P Maycock, R Little, A Ward, N Kassem, J Evans, D Ganderton, R Stone, P Barnes, K Chung, J Thompson, J Hall, J Scott, A Morice
Journal: Thorax (1991)

In 33 asthmatics (17 males) estimates of breathlessness during exercise were compared with lung volumes, peak flow (PEF) variation, six minute walking distance (6-MWD) and disability (MRC dyspnoea scale).The patients' mean age was 44 years (range 17-70), mean FEV, was 85% predic- ted (range 33-118%).Lung volumes (VC, RV, TLC, RV/TLC) were measured spiro- metrically and by helium dilution.PEF was recorded twice daily for 14 days.Variation in PEF was estimated using the amplitude or the standard deviation of the daily variation as a percentage of the mean or as a percentage of predicted PEF.Exercise was performed on a cycle ergometer.A one minute increment protocol was followed with work rates selected according to size and sex.Minute ventila- tion (VE) and dyspnoea were measured every minute.Dyspnoea was measured using the modified Borg scale and defined as "an uncom- fortable need to breathe."The mean number of work increments was 10 (range 6-14).The median r value for the dyspnoea/VE relation- ship was 0-88 (range 0-0 99).In three patients r was < 0-8; these were excluded from further analysis.The dyspnoea/VE relationship was normalised between patients by fitting height, sex, and a height-sex term to the regression.None of the measurements of lung volume, spirometry, or peak flow correlated with the dyspnoea/VE relationship (p > 0 3 in all cases).6MWD was negatively correlated with dyspnoea/VE (p = -0-46, p = 0-014) and MRC dyspnoea grade was positively correlated (p 0 38, p = 0 034).These results indicate that patients giving low scores for breathlessness relative to ventilation (after adjustment for height and sex) indicated less disability and walked faster than patients who indicated high levels of dyspnoea.These findings suggest that patients' perception of the level of their dyspnoea during exercise may condition their exercise tolerance and ensuing disability, but dyspnoea perception appears to be unrelated to disturbances in lung volumes and measures of airflow limitation.
GOVERNMENTAL INVESTIGATION REGARDING SPIRITUOUS LIQUORS.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathogenesis of Hemorrhagic Infarction of the Brain. I. Role of Hypertension and of Collateral Circulation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detection of Entamoeba Histolytica by Fluorescent Microscopy
Journal: BMJ (1962)

ANY QUESTIONS?MEDImALJOUN.obvious cardiac enlargement and clear symptoms.Occasionally patients with very severe pulmonary hypertension or pulmonary atresia also may have no murmur, but again from cyanosis and symptoms they obviously have severe heart disease.In general, then, one can say that the only reasonably common condition in which a murmur is likely to be absent is coarctation of the aorta.Contraindications to Immunizations Q.-What conditions in the patient might contraindicate the following immunizations: smallpox, cholera, T.A.B.T., yellow fever, poliomyelitis (Salk and Sabin), influenza, diphtheria, pertussis, tetanus, and the triple vaccine containing the last three ?A.-What may be termed " general " contraindications to all immunological procedures include severe or debili- tating disease, acute infections, long-standing cortisone therapy (most cases), and the proximity of certain other immunological measures, with the proviso that in the face of existing or potential epidemic circumstances protective vaccination takes priority.Other contraindications are set out in the Table.Vaccine Contraindications Smallpox .. .. (1) Age: I month (teething troubles
Correction
Authors: ROBERT L. CAPIZZI
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 September 1971CorrectionROBERT L. CAPIZZI, M.D.ROBERT L. CAPIZZI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-3-482_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to correct an error in the paper "L-Asparaginase: Clinical, Biochemical, Pharmacological, and Immunological Studies," which appeared in the June issue of the ANNALS. In Table 1 Patients D.C., C.T., G.S., D.G., D.B., M.P., E.E., and T.W. all have the "Duration of Disease Before L-Asparaginase" listed as 21 months. It should in fact have read < 1 month. This error does not affect the major content of the paper or the conclusions.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Research Laboratory Department of the Army Edgewood Arsenal, Md. 21010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1971Volume 75, Issue 3Page: 482-482 Issue Published: 1 September 1971 PDF DownloadLoading ...
Biology of Bone Marrow Transplantation
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Biology of Bone Marrow Transplantation Get access JNCI: Journal of the National Cancer Institute, Volume 63, Issue 5, November 1979, Page 1285, https://doi.org/10.1093/jnci/63.5.1285-a Published: 01 November 1979
Trends in cigarette smoking in the United States. Educational differences are increasing
Authors: J. P. Pierce
Journal: JAMA (1989)

National trends in smoking prevalence by educational category from 1974 through 1985 show that education has replaced gender as the major sociodemographic predictor of smoking status. Smoking prevalence has declined across all educational groups but the decline has occurred five times faster among the higher educated compared with the less educated. From 1974 to 1985, smoking prevalence among persons with less than a high school diploma declined to 34.2% (0.19 percentage points per year) whereas prevalence for persons with four years or more of college education declined to 18.4% (0.91 percentage points per year). Smoking cessation activity increased across all educational groups, but the rate of increase among the higher educated was twice that of lower-educated groups. Initiation of smoking among more-educated men decreased rapidly to 15% in 1985 but leveled off by 1987. Until 1985, less-educated young females were the only group in which smoking initiation was increasing. However, in 1987 a sudden and large decline in initiation among less-educated females occurred. The apparent recent changes in initiation patterns by educational level suggest that the converging of smoking prevalence between the genders may not continue. The large and widening educational gap in smoking suggests that health promotion priorities need to be reassessed. (<i>JAMA</i>1989;261:56-60)
EXTH-10. A VERSATILE AND MODULAR TARGETED NANOPARTICLE PLATFORM FOR DELIVERY OF COMBINATION THERAPIES TO ADULT AND PEDIATRIC CNS TUMORS
Authors: Fred Lam, Stephen Morton, Jeffrey Wyckoff, Tu-Lan Vu Han, Mun Hwang, Amanda Maffa, Elena Balkanska-Sinclair, Michael Yaffe, Scott Floyd, Paula Hammond
Journal: Neuro-Oncology (2018)

Effective treatment of CNS tumors is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed nanoparticles (NPs) that can be functionalized with ligands, such as transferrin (Tf-NPs), for delivery across the BBB to deliver multiple cargo to CNS tumors. In vitro uptake studies in U87MG and GL261 GBM cell lines demonstrate increased intracellular uptake of Tf-NPs compared to non-functionalized NPs in a time-dependent manner. Using intravital imaging through a cranial window, we show the ability of Tf-NPs to traverse the intact BBB in non-tumor bearing mice as well as achieve direct and durable tumor binding in intracranial orthotopic models of U87MG and GL261 GBM. Treatment of tumor-bearing mice with Tf-NPs loaded with temozolomide (TMZ) and the bromodomain inhibitor JQ1 leads to superior therapeutic effects with increased DNA damage and apoptosis that correlates with a 1.5- to 2-fold decrease in tumor burden and corresponding increase in survival compared to mice treated with drugs packaged in non-functionalized NPs or mice treated with equivalent free-drug dosing. Immunocompetent mice treated with Tf-NP-loaded drugs also show relative protection from the effects of systemic drug toxicity due to TMZ and JQ1. Preliminary intravital imaging further shows the ability of our NPs to target pediatric tumors such as medulloblastoma, demonstrating the preclinical potential of this nanoscale platform to deliver novel combination therapies to adult and pediatric CNS tumors.
Substance use among senior medical students. A survey of 23 medical schools
Authors: D. C. Baldwin
Journal: JAMA (1991)

Senior students at 23 regionally distributed medical schools received an anonymous questionnaire designed to examine current and prior use of tobacco, alcohol, and nine other drugs. The overall response rate was 67% (N = 2046). Substance use prevalence rates during the 30 days preceding the survey included alcohol, 87.5%; marijuana, 10.0%; cigarettes, 10.0%; cocaine, 2.8%; tranquilizers, 2.3%; opiates other than heroin, 1.1%; psychedelics other than LSD (lysergic acid diethylamide), 0.6%; amphetamines, 0.3%; barbiturates, 0.2%; LSD, 0.1%; and heroin, 0.0%. Compared with national, age-related comparison groups, senior medical students reported less use of all substances during the past 30 days and the past 12 months, except for alcohol, tranquilizers, and psychedelics other than LSD. Substantial new drug use after entry into medical school was reported only for tranquilizers. Seven students (0.2%) admitted to current dependence on a substance other than tobacco, four of these implicating marijuana. Thirty-three students (1.6%) believed that they currently needed help for substance abuse. Only 25.7% were aware of any policy on substance abuse at their own school. (<i>JAMA</i>. 1991;265:2074-2078)
Angiographic assessment of reperfusion in acute myocardial infarction by myocardial blush grade
Authors: Jose P. Henriques, Felix Zijlstra, Arnoud W. ban 't Hof, Menko-Jan de Boer, Jan-Henk E. Dambrink, Marcel Gosselink, Jan C. Hoorntje, Harry Suryapranata, Isala Klinieken
Journal: Journal of the American College of Cardiology (2003)