tbuckley/cabot-search huggingface dataset:
Astrology in Europe
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE NEW ILLINOIS BILL FOR THE COMMITMENT OF THE INSANE.
Journal: JAMA (1893)

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Extraneural metastasis of medulloblastoma
Authors: A. Mazloom, A. H. Zangeneh, B. S. Teh, A. C. Paulino
Journal: Journal of Clinical Oncology (2009)

2065 Background: Medulloblastoma is the most common childhood intracranial tumor to spread extraneurally. Information regarding prognostic factors and best therapeutic approach of extraneural metastasis (ENM) of medulloblastoma is mostly limited to case reports. The purpose of this study was to perform a comprehensive literature review and analysis of reported cases dealing with ENM to identify the characteristics, prognostic factors, optimal treatment modalities, and survival of these patients. Methods: A PubMed search of English language articles from 1963–2007 was performed, yielding 47 articles with 119 patients. Factors analyzed included age, time interval to ENM, CNS involvement at the time of ENM, location of ENM, treatment, and outcome. Results: Location of ENM included bone in 84%, bone marrow in 27%, lung in 6%, liver in 6%, and lymph nodes in 15%. Of patients with available data regarding location of RT after ENM, 87% of patients received this treatment to the site of ENM. The 1-year disease free survival (DFS) and overall survival (OS) after the diagnosis of ENM was 35% and 42%, respectively. The 1-year OS for patients with and without radiotherapy (RT) after ENM was 58% and 35%, respectively (p = 0.019). For patients without CNS involvement at the time of ENM the 1-year OS for those treated with and without RT was 82% and 51%, respectively (p = 0.030), however RT did not significantly improve OS for those with CNS involvement. ENM in the lung or liver was found to be a negative prognostic factor (p = 0.002). 1-year OS of patients with time interval to ENM of &lt;18 months was 25% while those with time interval greater than or equal to 18 months it was 61% (p = 0.001). Conclusions: Negative prognostic factors for patients with ENM include CNS involvement at the time of ENM, lung or liver involvement, and duration to ENM &lt;18 months. Patients without CNS involvement who received RT after ENM had an OS and DFS benefit compared to those not receiving RT. No significant financial relationships to disclose.
Amebic Liver Abscess
Authors: Hsin-Hui Wang, Wei-Ru Lin
Journal: New England Journal of Medicine (2018)

A 29-year-old man with HIV presented with fever and abdominal pain. Computed tomography of the abdomen revealed a ring-enhancing hepatic lesion, and a polymerase-chain-reaction assay of stool confirmed infection with Entamoeba histolytica.
Hygiene and Morality.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanistic Considerations for Carcinogenic Risk Estimation: Chloroform
Authors: R. H. Reitz, T. R. Fox, J. F. Quast
Journal: Environmental Health Perspectives (1982)

Chloroform has been reported to induce cancer in rodents after chronic administration of high doses by gavage. However, the interpretation of these findings is hampered by a lack of knowledge concerning the relative roles of genetic and nongenetic mechanisms in these bioassays. The present studies were carried out in male B6C3F1 mice in order to investigate the potential of chloroform to induce genetic damage and/or organ toxicity at the sites where tumors have been observed in the various bioassays. These studies revealed that carcinogenic doses of chloroform produced severe necrosis at the sites where tumors later developed. This was demonstrated by light microscopy as well as by determination of the cellular regeneration index following administration of 3H-thymidine. Noncarcinogenic doses of chloroform failed to induce these responses. In contrast, studies of DNA alkylation and DNA repair in vivo failed to give any indication that chloroform had produced the type of genetic alterations associated with known genotoxic chemicals. These data suggest that the primary mechanism of chloroform-induced carcinogenesis is nongenetic in nature. If the same mechanism predominates in man, there should be little to no carcinogenic risk associated with exposure to noncytotoxic levels of chloroform.
Abstract O.53: Occult Coronary Artery Dilatation: An Unrecognized Category Of Coronary Involvement
Authors: Soha Rached-d'Astous, Nour Rached-d'Astous, Frederic Dallaire, Nagib Dahdah
Journal: Circulation (2015)

Background: The current definition of Coronary artery dilatation (CAD), Z-score &gt;2.5, in KD may omit patients at higher risk of later complications. We propose a category of occult CAD with a Z-score variation ≥ 2 for the same CA on 2 different echocardiograms, but absolute Z-score &lt; 2.5. We compared this new category with cases of CAD and normal CA. &gt;Method: A retrospective review included 337 patients diagnosed with KD in our institution. Echographic data were retrieved for the fist year following diagnosis. Patients were classified in three categories: definite CA dilatation (dCAD) with Z-score ≥ 2.5, occult CA dilatation (oCAD) and normal CA (nCA). We compared inflammatory profile, IVIG treatment resistance, and timing of CA involvement. Results: There were 26.3% patients with nCA, 32.2% with oCAD and 41.1% with dCAD.Patients with KD incomplete diagnostic criteria represented 35%, 14% and 17% for NCAD, OCAD and DCAD groups respectively (p=0.008). Median time for CAD was 7 and 9.5 days for dCAD and oCAD respectively (p=0.2). A Jonckheere trend test identified a progression of inflammatory parameters through the three groups for Platelet count (p&lt; 0.001), Albumin (p = 0.007), ESR (p = 0.04), but not for CRP (p = 0.76) and WBC (p = 0.16). There was a significant difference in treatment resistance, with 5%, 19% and 31% for NCAD, OCAD and DCAD respectively (p=0,002). Conclusion: OCAD group appears like a distinctive subgroup of KD patients showing intermediate inflammatory profiles and treatment respond in the NCAD to DCAD spectrum. Recent Z-score equations, more accurate for young patients’ CA size than former linear equations, may explain the high incidence of dCAD in this report. Further studies are needed to define the profile and propensity to complications of this subpopulation.
Die neuzeitlichen Brustwand- und Extremitäten-Ableitungen in der Praxis
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRI0189 Prognostic significance of limited and difusse form of skin changes in systemic sclerosis
Authors: NS Damjanov, G Dobrosavljevic, S Pavlov, G Radunovic, I Vukovic, N Todorovic, M Milenkovic, P Ostojic
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To assess the difference in frequency of pulmonary and renal involvement, as well as lungs insufficiency and renal failure between patients (pts) with limited cutaneous Systemic Sclerosis (lcSSc) and difusse cutaneous Systemic Sclerosis (dcSSc). <h3>Methods</h3> Group of 138 pts with Systemic Sclerosis (SSc), 127 females and 11 males, age 28–75 years (median 53), were followed for 3–26 (median 13) years period. Extent of skin involvement was recorded, and pts were examined for radiographic signs of pulmonary fibrosis, carbon monoxide transfer (TCO) factor (done in 28 pts), and renal involvement and failure (urine sediment, creatinin clearance, arterial tension). Difference of visceral involvement, pulmonary insufficiency and renal failure between pts with lcSSc and dcSSc was correlated. <h3>Results</h3> Among 138 pts, 105(76%) had lcSSc, and 33(24%) dcSSc. Pulmonary lession were found in 40/105 pts with lcSSc, and in 25/33 pts with dcSSc (p = 0,004-χ2 test). Renal lession was detected in 11/105 pts with lcSSc, and in 8/33 pts with dcSSc (p = 0,04-χ2 test). Signs of lung insufficiency developed in 30/105 pts with lcSSc, and in 18/33 pts with dcSSc (p = 0,04-χ2 test). Lower creatinin clearance and high arterial blood preasure were detected in all patients with recorded renal lession during the follow up period (in 11/105 pts with lcSSc, and in 8/33 pts with dcSSc). Renal failure was significantly more frequent in dcSSc pts (p = 0,04-χ2 test). In 7(21%) pts with dcSSc no criteria for pulmonary and renal involvement were present during the follow up period. On the other hand, in 14(13%) pts with lcSSc pulmonary insufficiency or renal failure were recorded in first 5 years of disease duration. <h3>Conclusion</h3> Difusse cutaneous lessions were prognostic sign of lungs and kidneys involvement, as well as pulmonary insufficiency and renal failure in most of the patients, but about 20% of the dcSSc patients were without severe visceral lessions during the 13 years of follow up period. On the other hand, 13% of patients with limited cutaneous lessions had bad prognosis and developed pulmonary insufficiency or renal failure in first 5 years of disease duration.
Vectorcardiography
Authors: G. E. BURCH, J. A. ABILDSKOV, J. A. CRONVICH
Journal: Circulation (1953)

Both theoretic considerations and actual studies suggest that spatial vectorcardiography will eventually have practical applications. It is likely to furnish clinically useful information in addition to that provided by conventional electrocardiography. This is a statement of probability, however, and has not yet been established, nor have the circumstances in which it may apply yet been defined. For this reason the current status of vectorcardiography is properly that of a research method, not yet suitable for general clinical application. Many technics have been employed to obtain the vectorcardiogram. The graphic derivation of vectorcardiograms from electrocardiographic leads is of historic interest only. The use of the cathode ray oscilloscope with suitable amplifiers is the method of choice. Many modifications of technic, such as recording on moving film, recording of successive complexes, and stereoscopic recording, are possible with the use of the cathode ray oscilloscope. It is not yet apparent which recording technic will prove to be most informative, so that studies with a variety of technics seem advisable. Several systems of electrode placement have been advocated for obtaining the spatial vectorcardiogram. Since the application of any geometric reference frame to the human body necessitates several assumptions which are not actually true, it appears that the choice among reference frames cannot be made on the basis of their intrinsic validity. We are of the opinion that the equilateral tetrahedron introduced by Wilson and associates 12 offers advantages over other reference frames because: (1) Only one electrode is necessary in addition to those employed to obtain the standard electrocardiographic leads. (2) Electrodes are easily applied, and their positions are readily reproducible. (3) The knowledge already available from experience with the standard leads of the electrocardiogram may be applied to spatial vectoreardiography. (4) Each of the four surfaces defined by the electrode positions is an equilateral triangle. (5) The disadvantages of this reference system are common to those of other proposed reference frames. Variations of the spatial vectorcardiogram in normal man and in man with a variety of disease states have been studied by several groups of investigators with a variety of technics. These studies are of considerable importance, but as yet nearly all lack pathologic confirmation of the presence, site and size of suspected lesions. These data must be obtained and thoroughly correlated with the vectorcardiogram before vectorcardiography can be employed with certainty in general clinical practice.
Editorials
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Personal View
Authors: L W Batten
Journal: BMJ (1979)

<b>585</b> <h3><b>Objectives</b></h3> Peptide receptor radionuclide therapy (PRRNT) for neuroendocrine neoplasms (NENs) is potentially nephrotoxic in the long-term, especially in the presence of risk factors like hypertension and diabetes. The purpose of this study was to evaluate the long-term renal function in patients undergoing at least 5 cycles of PRRNT with Lu-177 and/or Y-90 labeled DOTATATE or DOTATOC. <h3><b>Methods</b></h3> We have treated more than 1100 patients with metastasized and progressive NENs with up to 9 cycles of PRRNT and a time interval of 3 - 4 months between successive cycles, using Y-90, Lu-177 or a combination of Y-90 and Lu-177 labeled DOTATATE or DOTATOC (administered sequentially, i.e., DUO PRRNT or concomitantly, i.e., TANDEM PRRNT). PRRNT was performed under strict nephroprotection in all patients, i.e., with concurrent infusion of amino acids lysine/arginine. Patients treated with Y-90 were additionally co-infused with gelofusine. Changes in renal function were monitored in all patients by serial measurements of tubular extraction rate (TER) using Tc-99m MAG3 and of the glomerular filtration rate (GFR) using Tc-99m DTPA. The results of long-term renal function were analyzed in 217 patients treated with 5 or more PRRNT cycles and followed-up for at least 1 year after the last cycle. The activity administered per cycle ranged from 6.4 to 8.2 GBq for Lu-177 and 3.2 to 5.9 GBq for Y-90. The total administered activity ranged from 16.5 to 44 GBq of Lu-177 and/or Y-90. <h3><b>Results</b></h3> None of the patients had grade-3 or higher renal toxicity (end stage renal insufficiency). Grade-1 renal toxicity was observed in 28 patients (13%), while 12 patients (5.5%) showed grade-2 toxicity. Fall in TER of more than 20% was found in 17 patients (7.8%). <h3><b>Conclusions</b></h3> Using the long-term low-dose protocol with appropriate fractionation and under adequate nephroprotection, administration of multiple cycles of PRRNT is safe and long-term detrimental effect on renal function can be minimized or avoided.
Neurology
Authors: Kenneth R. Magee
Journal: JAMA (1967)

This new edition of "Grinker, Bucy and Sahs" is welcome, particularly to the many neurologists who have gleaned so much from the pages of previous editions. Many popular texts old enough to reach a sixth edition suffer from repeated surgery (or lack thereof) and would better be put out to pasture than left to run the race. Fortunately, the aging of this book has been more like that of wine, enhancing its flavor and value. Dr. Bucy, a former coauthor, did not participate in this latest revision. Dr. Sahs has skillfully rewritten and revised the work, successfully including recent advances in neurology and related basic sciences without altering the book's primarily clinical orientation. He has modified all clinical sections, and although it is difficult to single out the most significant changes, the analysis of current trends in cerebrovascular disease is particularly impressive. Despite its clinical focus, the text does not
Anisakiasis from the American perspective
Authors: R. E. Fontaine
Journal: JAMA (1985)

Human anisakiasis results from accidental infection with larval ascarid nematodes, which normally parasitize several phyla of marine life during their complex life cycle.<sup>1,2</sup>Larvae from two genera,<i>Anisakis and Phocanema</i>, of the family Anisakidae, have been definitely identified from human cases, but<i>Anisakis</i>has produced by far the greater number of human cases. Adult worms of these two genera infest the stomachs of marine mammals, attaching and burrowing into the mucosal surface in dense clusters. Unembryonated eggs passed in the stool develop and hatch in sea water to produce sheathed secondstage larvae. After ingestion by a small crustacean, the larva molts and encysts in the crustacean's body cavity. The larval worm then encysts in the viscera or muscles of any fish that eats these parasitized crustaceans. Fish or squid that eat other parasitized fish also become parasitized. During repeated passages from one fish to another, the larvae may grow
Pretreatment antibody titers in repeated rabies prophylaxis
Authors: L. I. Lutwick
Journal: JAMA (1980)

SINCE the number of animal bites in the United States exceeds 1 million each year,<sup>1</sup>practicing physicians will at times be forced to make a decision whether to initiate postexposure rabies prophylaxis. The basic guidelines for the treatment of individuals bitten by animals have been outlined by the Center for Disease Control (CDC).<sup>2</sup>However, unusual circumstances not well covered by these guidelines occasionally arise. We have recently seen two cases involving animal bites in which the person had previously received one or more courses of rabies prophylaxis. Because the recommendations for repeated rabies prophylaxis in previously unimmunized individuals seem somewhat arbitrary, we are reporting these incidences to stress the importance of the pretreatment rabiesneutralizing antibody titer in directing the length of treatment. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 16-year-old high school student was referred to the University of Iowa, Iowa City, because of a recent potential rabies exposure.
接受过骨髓移植的大疱性表皮松解症患者的慢性伤口可由同一供体的皮肤移植治愈
Journal: British Journal of Dermatology (2021)

作为对 RDEB 中的 BMT 进行的研究的一部分, 美国明尼苏达州的医生使用 CelluTome