tbuckley/cabot-search huggingface dataset:
Journal of Immunology, Baltimore
Journal: JAMA (1966)

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Die psychopathischen Verbrecher: Die Grenzzustände zwischen geistiger Gesundheit und Krankheit in ihren Beziehungen zu Verbrechen und Strafwesen. Für Ärzte und Juristen.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reye syndrome. A correlated electron-microscopic, viral, and biochemical observation
Authors: T. T. Tang
Journal: JAMA (1975)

Liver biopsy specimens of two patients with Reye syndrome were examined for ultrastructural features, viral isolation, and urea-cycle enzyme activity. Concurrent presence of herpes-like virus and myxovirus/paramyxovirus was demonstrated by electron microscopy, and viral infections were confirmed by isolation or serologic tests. A concomitant hepatic ornithine transcarbamoylase deficiency was also noted. The pathogenesis in these instances seems to consist of an initial synergistic insult on the liver by mixed types of viruses and subsequent breakdown of urea cycle, Krebs cycle, and possible other hepatic functions. An exodus of glycogen granules into the hepatic spaces of Disse and sinusoids suggests that the viruses have injured the plasma membranes as well as the mitochondria of hepatocytes. Since Kapila et al reported similar disorders five years before Reye et al, the name of Kapila-Reye disease is suggested. (<i>JAMA</i>232:1339-1346, 1975)
Coronary Artery Bypass With Only In Situ Bilateral Internal Thoracic Arteries and Right Gastroepiploic Artery
Authors: Hiroshi Nishida, Yasuko Tomizawa, Masahiro Endo, Hitoshi Koyanagi, Hiroshi Kasanuki
Journal: Circulation (2001)

Background With the rapid advance of catheter intervention, the direction taken by surgeons is not only to make conventional CABG less invasive but also to pursue better long-term results by using more arterial conduits. Methods and Results Between July 1989 and April 2000, 239 patients (218 men, 21 women) with a mean age of 59.7 (range 39 to 79) years underwent CABG with exclusive use of both internal thoracic arteries (ITAs) and the right gastroepiploic artery (RGEA). ITA grafts were harvested by using the skeletonization technique. Most patients (96%) had either triple-vessel or left main disease. Fifty percent of the patients were diabetic, and 16 were being treated with insulin. The left ventricular ejection fraction was ≤40% in 46 patients (19%). Eleven patients (5%) had chronic renal failure and were on hemodialysis. Follow-up was completed in 235 patients (98%). Postoperative follow-up averaged 43 (range 1 to 129) months. Sequential grafting was performed in 64 patients, and the mean number of anastomoses was 3.3. One patient (0.4%) died of mediastinitis on the 53rd postoperative day. Graft patency was confirmed angiographically in 230 patients (96%) 2 to 3 weeks after surgery. The patency rate was 97.1% for the left ITA, 99.6% for the right ITA, and 95.5% for the RGEA. Five-year actuarial survival rate was 92.9%, and the cardiac death-free rate was 97.8%. Conclusions Complete arterial grafting with both ITAs and RGEA was associated with minimal operative risk, a high early graft patency rate, and excellent long-term results.
Abstract 5303: Decreased Affinity of Calmodulin Binding to RyR2 May Cause Leaky Channel in CPVT-Associated Mutation: Insight from RyR2 <sup>R2474s/+</sup> Knock-In Mouse Model
Authors: Xiaojuan Xu, Masafumi Yano, Takeshi Suetomi, Makoto Ono, Hitoshi Uchinoumi, Hiroki Tateishi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Tomoko Ohkusa, Masunori Matsuzaki
Journal: Circulation (2008)

Calmodulin (CaM), one of the accessory proteins of the cardiac ryanodine receptor (RyR2), has been shown to play a significant role in regulating the channel gating in RyR2. However, the role of calmodulin on the channel gating in diseased hearts is unclear. Here, using knock-in (KI) mice model with CPVT-associated RyR2 mutation (R2474S), we investigated whether CaM plays a role in the pathogenesis of CPVT. Sarcoplasmic reticulum (SR) vesicles were isolated from mouse hearts (n=4). To evaluate the characteristics of CaM binding to RyR2, SR was mixed with various concentrations of CaM-SANPAH conjugate (16nM-256nM) , followed by UV photolysis. Then, the RyR2-bound CaM was detected by Western blotting using anti-CaM antibody. There was no significant difference in the affinity of CaM binding to RyR2 at baseline between KI (Kd=26nM) and WT (Kd=16nM). However, compared to WT, CaM binding was markedly decreased in response to cAMP (1 μM) in KI (18±1.9 % decrease, at 128nM CaM), although 2808Ser phosphorylation in RyR2 was similarly increased by cAMP in WT and KI. This decrease of CaM binding in KI was, however, markedly diminished by co-addition of dantrolene which was previously found to prevent the abnormal Ca 2+ leak by the correction of the defective inter-domain interaction between N-terminal (1–600) and central (2000–2500) domains in both MH-type and CPVT-type RyR2. Moreover, in the presence of FK506 (10μM), which was found to dissociate FKBP12.6 from RyR2 and subsequently to induce domain unzipping, CaM binding was indeed decreased in WT, whereas unchanged by FK506 in KI. In saponin-permeabilized, isolated cardiomyocytes, line scan images in cardiomyocytes were obtained to measure local Ca 2+ release events using a confocal microscopy with Rhod-2 as a Ca 2+ indicator; [Ca 2+ ] was buffered at 30 nM by 0.5 mM EGTA. In the KI cardiomyocytes, the frequency of Ca 2+ sparks (SpF:s −1 ·100μm −1 ) was more increased than in WT, in response to cAMP (at 1μM; +33%, p&lt;0.01 vs WT). In conclusion, CaM binding ability to RyR2 seems to be markedly decreased in response to PKA phosphorylation in KI mice, perhaps via defective inter-domain interaction, causing spontaneous diastolic Ca2+ sparks that may lead to triggered activity and hence lethal arrhythmia.
HYDROGEN-ION CONCENTRATION OF THE CONTENTS OF THE SMALL INTESTINE
Journal: JAMA (1920)

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Physical Diagnosis.
Journal: JAMA (1928)

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Medical Malpractice
Authors: Walter G. Gunn
Journal: JAMA (1977)

The medical reader may be forgiven if he seems less than enthusiastic about another collection of essays addressed to the malpractice crisis. However, if he has more than a casual interest in the subject, he will benefit from a careful perusal of this scholarly work, a symposium from the Duke Law Journal presenting a serious and objective look at the problem by a group of authorities. This small volume provides an insightful analysis of the medical and insurance aspects of a complex problem. Furthermore, it illumines the social engineering and thinking in the concepts of Health Maintenance Organizations and national health insurance. Quality of care assurance appears inextricably entwined with most malpractice solutions, and the chapter on "Quality of Care" outlines succinctly the problems in assessing this concept. Particularly lucid is the distinction between "art-of-care" and technical care and between evaluating quality according to the patient's standards (ie, outcome data)
Books Received
Journal: JAMA (1901)

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UKRAINE
Journal: JAMA (1930)

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Peer Review
Authors: A. Michael Pardue
Journal: JAMA (1973)

<h3>To the Editor.—</h3> "Teaching Peer Review" by Peter Peterson (224:884, 1973) raises several questions. For example, why is peer review so distasteful not only to physicians but to everyone else? The concept of having to teach peer review is somewhat reminiscent of George Orwell's "1984" in which society in general reaches a point of having "big brother" watch over everyone. Historically, in order to implement such a distasteful system, one must program the minds of youth to accept this as the only way—as if no other way exists. Examples of this in past and recent history were the Hitler Youth Movement and the indoctrination of children in communist countries. I have the feeling that somehow we, as a group of professional people, are being singled out and perhaps discriminated against concerning peer review. Why should we accept such a system, particularly when it has to be taught to individuals at
Anaphylactic shock, acute renal failure, and disseminated intravascular coagulation. Suspected complications of zomepirac
Authors: V. T. Smith
Journal: JAMA (1982)

ZOMEPIRAC sodium is a nonsteroidal, anti-inflammatory agent available since November 1980. It was developed as an analgesic and has been described by the manufacturer as safe and well tolerated. There is a previous report of an anaphylactic reaction, secondary to zomepirac, in the literature.<sup>1</sup>This report presents the occurrence of anaphylactic shock, disseminated intravascular coagulation, and acute renal failure following the ingestion of zomepirac. <h3>Report of a Case</h3> A 66-year-old man came to the emergency room with a six-hour history of nausea, vomiting, and diarrhea. He also noted chills, but his temperature was not taken at home. Some occasional mild abdominal cramping was noted with the diarrhea. One week before admission the patient noted a similar type of illness with chills, nausea, vomiting, and diarrhea, but it lasted only two hours and subsided spontaneously. He felt well prior to and in between these episodes. Additional history indicated that he
Hematopoietic Hormone in Pernicious Anemia.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deaths
Journal: JAMA (1930)

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Massachusetts Medical Society
Authors: Alfred Weller, John Figgis Jewett
Journal: New England Journal of Medicine (1961)

STATED MEETING OF THE COUNCILA stated meeting of the Council will be held in John Ware Hall, Boston Medical Library, 8 The Fenway, Boston, on Wednesday, February 1, 1961, at 10 a.m. The Cotting–Woodward Luncheon will be held from 12 m.-l p.m. Business: Call to order at 10 a.m.Presentation of record of meeting held October 5, 1960, as published in Vol. 263, Supplement No. 2, November 3, 1960, of the New England Journal of Medicine.Reports of standing and special committees.Such other business as may legally come before this meeting.Robert W. Buck, M.D. Secretary COMMITTEE . . .
ON REVISING THE MEDICAL CURRICULUM
Journal: JAMA (1925)

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Table of contents
Journal: Hepatology (2019)

Cover Figure : Utilizing a model of precision-cut bile duct slices, peribiliary glands have been shown to be key in regeneration of biliary epithelium after severe ischemic bile duct injury.Restorative responses included: proliferation, maturation, and migration of peribiliary gland cells, subsequent restoration of biliary epithelium, initiation of HIF-dependent pathways, and accumulation of myofibroblasts.
峰值瘙痒数字评价量表的验证
Authors: G. Yosipovitch, M. Reaney, V. Mastey, L. Eckert, A. Abbé, L. Nelson, M. Clark, N. Williams, Z. Chen, M. Ardeleanu, B. Akinlade, N.M.H. Graham, G. Pirozzi, H. Staudinger, S. Plaum, A. Radin, A. Gadkari
Journal: British Journal of Dermatology (2019)

特应性皮炎 (AD) 是一种慢性皮肤病,在全世界成人中的发生率为 5 - 10%。其可导致强烈的持续性瘙痒。对于几乎 2/3 的中度至重度 AD 患者,瘙痒持续至少每天 12 小时,而且严重到无法承受的程度。在研究 AD 治疗的有效性的临床试验中,必须测量瘙痒强度。鉴于瘙痒是主观感觉,瘙痒强度由患者自己报告最准确。在本研究中,美国和欧洲的研究者开发了一个瘙痒量表,称作峰值瘙痒数字评价量表(NRS)。该量表通过要求患者“使用一个 0 至 10 的评分系统评定在先前 24 小时内出现的最严重瘙痒的强度,其中 0 表示‘无瘙痒’,10 表示‘极度瘙痒’”,测量在过去 24 小时内的最严重瘙痒(峰值瘙痒)。为确定该量表的可靠性和有效性(即,适用于评估 AD 患者的瘙痒强度),就患者对该量表的看法对其进行了采访。然后在 3 项大型中度至重度 AD 成人患者临床试验中运用该量表进行评估。受采访的患者称,该量表对瘙痒强度提供了一个相关的、明确的、综合的评估。假设,峰值瘙痒 NRS 的评分表示与其他瘙痒测量值呈中度至强相关性,或者与 AD 体征(临床症状)测量值呈弱至中度相关。研究总结,峰值瘙痒 NRS 是一个明确定义的、可靠的、敏感的有效量表,适用于评估中度至重度 AD 成人患者的最严重瘙痒强度。
The physician's physiology and his power of healing
Authors: C. D. Aring
Journal: JAMA (1976)

JUSTICE Cardozo said that there is an accuracy that defeats itself by overemphasis of details, and that one must permit oneself, quite advisedly and deliberately, a certain margin of misstatement. This rule applies not only in the legal profession; in medicine too, detail quite often conceals meaning. The human organism resists digital quantification and an excessively concrete approach tends to be self-defeating. An interesting observation in this vein was made by Samuel Butler in the late 19th century. The author of<i>Erewhon</i>(1872), who had more than a little insight into the human condition, entered the following in his<i>Notebooks</i>(chap 14): "A physician's physiology has much the same relation to his power of healing as a cleric's divinity has to his power of influencing conduct." A "refinement" that is generally less than helpful to the patient is the practice of admitting to the hospital the ordinary or nonurgent patient