tbuckley/cabot-search huggingface dataset:
Impact of tumor location on local recurrence after nephroureterectomy for upper tract urothelial carcinoma: Implications for adjuvant radiotherapy.
Authors: Sangjun Yoo, Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
Journal: Journal of Clinical Oncology (2016)

390 Background: To date, risk factors for local recurrence after complete removal of upper tract urothelial carcinoma (UTUC) have not been clearly identified. We evaluated the impact of tumor location on local recurrence in UTUC patients underwent radical nephroureterectomy. Methods: Among UTUC patients who underwent radical nephroureterectomy between 1998 and 2012, 192 (54.4%) patients with renal pelvic tumor and 161 (45.6%) patients with ureter tumor were included. Local recurrence was divided into regional lymph node recurrence (LNR) and surgical bed recurrence (SBR). The significance of tumor location and other variables on local recurrence were evaluated. Results: Lymphovascular invasion (p = 0.003), carcinoma in situ (p = 0.006) and high grade tumor (p &lt; 0.001) were more common in ureter tumor. During median follow-up period of 73 months, local recurrence was occurred in 33 (9.3%) patients. Among subtype of local recurrence, SBR (8.1 vs. 2.1%, p = 0.011) were more common in patients with ureter tumor compared to renal pelvic tumor although the probability of regional LNR was not significantly different according to tumor location (7.5% vs. 3.1%, p = 0.088). 5-year local recurrence-free survival (80.5% vs. 94.2%, p = 0.002), LNR-free survival (89.8 vs. 96.5%, p = 0.046) and SBR-free survival (88.3% vs. 97.6%, p = 0.005) were inferior in ureter tumor compared to renal pelvic tumor. Ureter tumor (HR; 2.552, p = 0.017), high grade tumor (HR; 3.064, p = 0.016) and advanced tumor stage (≥T3) (HR; 3.236, p = 0.002) were associated with local recurrence. Ureter tumor (HR; 4.704, p = 0.002) and advanced tumor stage (HR; 4.840, p = 0.006) were risk factors for SBR. However, tumor location was not associated with LNR although lymphovascular invasion (HR; 5.451, p &lt; 0.001) and high grade tumor (HR; 4.191, p = 0.012) were related with LNR. Conclusions: Ureter located tumor was associated with local recurrence which comes from the SBR. Adjuvant radiotherapy or surgical technique for reducing the risk of SBR should be considered in patients with ureter tumor.
Science, Washington
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genomic characterization of HCV in virmic patients with normal alt Clinical Medica 2, University of Padova, *IGGEB Trieste, Italy
Journal: Hepatology (1995)

The usefulness of identification of hepatitis C virus (HCV) genotype has recently been investigated for the clinical management of patients infected by HCV. In the present study, the HCV genotype infecting 127 patients was determined by two different methods: HCV genotyping using a dot-blot assay with type-specific probes derived from the 5′-UTR of HCV genome and HCV serotyping using an ELISA system in which type-specific antibodies against the NS4 region were detected. Overall, a good correlation of the two methods was observed, the main discrepancy being 4 patients with sequence-confirmed HCV-2 (2 cases) and HCV-3 (2 cases) genotypes recognized as HCV-1 by serotyping. Mixed infections were not detected by either method. In 19 PCR negative sera, in which the HCV genotype could not be evaluated, no particular serotype profile was observed. In conclusion, the molecular and serological techniques are almost equivalent in determining the viral type, although in individual cases, especially in PCR negative patients, the clinical meaning of the serotyping result remains to be determined.
THE SCALDED-SKIN SYNDROME
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Role of Cytogenetic Abnormalities in Acute Myeloid Leukemia with NPM1 mutations and No FLT3 Internal Tandem Duplication.
Authors: Jean-Baptiste Micol, Nicolas Boissel, Aline Renneville, Sylvie Castaigne, Claude Gardin, Claude Preudhomme, Herve Dombret
Journal: Blood (2009)
THE WAR
Journal: BMJ (1915)

Splint for Fractutres of the As rm.Major T. C. Litler Jones gave a demonstration of his spli/it for fractures of the arm.This simple and ingenious splint is made of iron wire framework moulded to dis- tribute the weightof the arm on to the trunk and chiefly the hip, and allows the patient tb walk about or to lie down in bed.It obtains flexion and abduction of the arm, and allows septic wounds of the arm to be dealt with without disturbing tlle position of the splint.The cost of making should not exceed is.It does not press in the -axilla and yet it can be adapted for the application of traction to the long bones.Major Litler Jones did not claim for it that it was absolutely ideal in every case, and he admitted that it did not prevent internal rotation of the lower fragment in cases-of fractures of the humerus.The weight of tllh splint was negligible, and one felt as if one's arm was resting lightlv on the arm of a chair.This splint has become very popular at the hospitals.in the same way as "ambulatory cases " in uninoculated persons.In tlhe discussion Captain Parsons related hlis experiences with cases of similar fever in Malaya.In none did Tifz P-miss 1
END OF THE PLAGUE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical importance of taste and smell
Authors: R. I. Henkin
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Goodhill's LETTER to the Editor (<b>218</b>:99, 1971) is interesting and raises several important points. The most important question raised relates to the contributory role of local abnormalities in the production on the new syndrome "Idiopathic Hypogeusia With Dysgeusia, Hyposmia, and Dysosmia" (<b>217</b>:434, 1971). It is clear that local taste nerve abnormalities can produce local hypogeusia. Similarly, any local lesion which obstructs the flow of odorant to the olfactory epithelium can produce hyposmia. Our study stated that each patient was "carefully" evaluated clinically and by laboratory test for any known cause of hypogeusia. Examinations included a battery of laboratory tests and examinations designed to uncover any metabolic, otorhinolaryngological, neurological, or genetic lesion. Results of these tests did not relate the hypogeusia to any previously described cause. It was for this reason that the hypogeusia was called idiopathic. However, the details of the otorhinolaryngological examination were not
Caveat Editor
Authors: Francis D. Moore
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Since publication of my EDITORIAL, "Reflections on New Treatments for Burns—Caveat Legor" (225:294,1973), I have received many letters—some humorous, others ill-tempered—calling attention to my error in using the word "legor." By way of apology, I offer the following: "<i>Legor</i>" (passive verb), `tis said, Meant, to Romans, "I am read." While in the eyes of a<i>perfector</i>The word for "reader," folks, is "<i>lector</i>." Now, who would make this stupid goof That floods the mails and raised the roof? Just a "<i>scriptor</i>" on The Burn Who has, as "<i>auctor</i>," much to learn. And yet, the weight of mail received Makes "<i>legor</i>" almost right, indeed!
The Lymphomas
Authors: Jane N. Winter
Journal: Annals of Internal Medicine (1998)

Medical Writings15 May 1998The LymphomasJane N. Winter, MDJane N. Winter, MDNorthwestern University Medical School, Chicago, IllinoisAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-10-199805150-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Canellos GP, Lister TA, Sklar JL. 581 pages. Philadelphia: WB Saunders; 1997. $175.00. ISBN 0721650309. Order phone 800-545-2522.Field of medicine: Hematology and oncology.Format: Hardcover book.Audience: Generalists and hematologist-oncologists.Purpose: To provide a fully integrated presentation of the lymphomas.Content: This book includes an introduction to the basic biology underlying the lymphoproliferative disorders, beginning with normal and abnormal lymphopoiesis and the molecular pathogenesis of lymphoid malignancies. It also includes an introduction to basic molecular biology and immunology for the uninitiated or for those looking for the background needed for an understanding of newer advances. The authors describe the ... Author, Article, and Disclosure InformationAffiliations: Northwestern University Medical School, Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1998Volume 128, Issue 10Page: 879KeywordsChemotherapyHematology and oncologyHistopathologyHodgkin lymphomaImmunologyLymphomaLymphoproliferative disorderMolecular biologyPathogenesisRadiation therapy Issue Published: 15 May 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ASEPTIC SUPPURATION IN RELATION TO ACUTE PLEURITIC EFFUSIONS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic engineering of T cells for increased homing to the tumor site
Authors: Manja Idorn, Gitte Holmen Olofsson, Hjalte List Larsen, Joost van den Berg, Özcan Met, Per thor Straten
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Adoptive cell transfer (ACT) using in vitro expanded T cells from biopsy material represents a highly promising treatment of disseminated cancer. ACT in its present form is rather crude and improvements seem within reach. Recruitment of transferred lymphocytes to the tumor site is
Shippen and Morgan and Benedict Arnold
Authors: Earl A. Bowen
Journal: JAMA (1966)

<h3>To the Editor:—</h3> In your editorial about John Morgan, founder of American medical education (<b>194</b>: 825, 1965) you state that there was bad blood between Drs. Morgan and Shippen, and that Dr. Morgan as director general of the US Army was dismissed by Congress in 1777, due to Shippen intrigue. Weren't there political overtones in that affair? The Shippens were Philadelphia loyalists (Tories) and a Philadelphia belle named Shippen was married to Gen Benedict Arnold. It was reported that the "André Spy Affair" to take West Point was in motion and that one of the conspirators was Mrs. Arnold and that Benedict Arnold knew nothing of it until André was arrested. Then General Arnold fled to the British lines. The American loyalists, or Tories, were bad medicine!
Glomectomy For Asthma: 'No Benefits'
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
Authors: D. H. Munn
Journal: Journal of Clinical Investigation (2004)

One mechanism contributing to immunologic unresponsiveness toward tumors may be presentation of tumor antigens by tolerogenic host APCs. We show that mouse tumor-draining LNs (TDLNs) contained a subset of plasmacytoid DCs (pDCs) that constitutively expressed immunosuppressive levels of the enzyme indoleamine 2,3-dioxygenase (IDO). Despite comprising only 0.5% of LN cells, these pDCs in vitro potently suppressed T cell responses to antigens presented by the pDCs themselves and also, in a dominant fashion, suppressed T cell responses to third-party antigens presented by nonsuppressive APCs. Adoptive transfer of DCs from TDLNs into naive hosts created profound local T cell anergy, specifically toward antigens expressed by the transferred DCs. Anergy was prevented by targeted disruption of the IDO gene in the DCs or by administration of the IDO inhibitor drug 1-methyl-D-tryptophan to recipient mice. Within the population of pDCs, the majority of the functional IDO-mediated suppressor activity segregated with a novel subset of pDCs coexpressing the B-lineage marker CD19. We hypothesize that IDO-mediated suppression by pDCs in TDLNs creates a local microenvironment that is potently suppressive of host antitumor T cell responses.
Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel Blockers vs Angiotensin-Converting Enzyme Inhibitors
Authors: F. H. Messerli
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Congenital bilateral chylothorax. Antepartum diagnosis and successful intrauterine surgical management
Authors: R. E. Petres
Journal: JAMA (1982)

ULTRASOUND imaging continues to be one of the most important diagnostic modalities available to the practicing obstetrician. However, the antenatal diagnosis of increasingly more complex pathological disorders in the fetus can complicate management plans. We report herein a case involving a recently recognized fetal problem and an innovative and successful technique of intrapartum intervention. <h3>Report of a Case</h3> A 26-year-old woman, gravida 2, para 1, was referred for diagnostic ultrasound at 36 weeks' gestation because of a rapid increase in fundal height, abdominal discomfort, and respiratory distress. Her first pregnancy had ended in the vaginal delivery of a normal 3,700-g infant after an uncomplicated pregnancy. There was no family history of congenital defects. The patient was not a diabetic. The present pregnancy had been complicated at 33 weeks by severe indigestion diagnosed by endoscopy as gastritis and duodenitis, for which she had been treated with cimetidine. The first ultrasound examination
Gaudeamus Igitur
Authors: John Stone
Journal: JAMA (1983)

For this is the day of joy which has been fourteen hundred and sixty days in coming and fourteen hundred and fifty-nine nights For today in the breathing name of Brahms and the cat of Christopher Smart through the unbroken line of language and all the nouns stored in the angular gyrus today is a commencing For this is the day you know too little against the day when you will know too much For you will be invincible and vulnerable in the same breath which is the breath of your patients For their breath is our breathing and our reason For the patient will know the answer and you will ask him ask her For the family may know the answer For there may be no answer and you will know too little again or there<i>will</i>be an answer and you will know too much forever For you
A phase 2 study of live-attenuated listeria monocytogenes cancer immunotherapy (ADXS11-001) in the treatment of persistent or recurrent cancer of the cervix (GOG-0265).
Authors: Warner King Huh, William E. Brady, Kathleen N. Moore, Heather A. Lankes, Bradley J. Monk, Carol Aghajanian, Don S. Dizon, Deborah K Armstrong, Premal H. Thaker, Paula M. Fracasso
Journal: Journal of Clinical Oncology (2014)

TPS5617 Background: This is a Gynecologic Oncology Group (GOG) Phase 2 study (NCT01266460, GOG 0265) of ADXS11-001 in patients with persistent or recurrent cancer of the cervix. ADXS11-001 is a live attenuated Listeria monocytogenes (Lm) immunotherapy bioengineered to secret a HPV E7 fusion protein targeting HPV-E7 transformed cells. A previous Phase I dose escalation study evaluated the safety of ADXS11-001 in patients with advanced cervical cancer (Maciag PA. Vaccine. 2009 Jun 18;27(30):3975-83). The primary objectives of this study are: to evaluate the tolerability and safety of ADXS11-001; and to assess the activity of ADXS11-001 in patients with persistent or recurrent cancer of the cervix. Secondary objectives are progression-free survival, overall survival and objective tumor response. Methods: Patient eligibility criteria: Females age ≥ 18 years with persistent or recurrent squamous or non-squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix with documented disease progression (disease not amenable to curative therapy). Patients must have measurable disease as defined by RECIST 1.1; have had one prior systemic chemotherapeutic regimen for management of their disease; have adequate organ function and must be free of active infection and not on antibiotics. This protocol is a 2-stage design with 12-month survival as the primary endpoint and with a planned sample size of up to 67 patients. Patients will receive ADXS11-001 at a dose of 1x109 CFU on Day 1 and repeat every 28 days for 3 total doses in the absence of disease progression or unacceptable toxicity, with each dose followed at 72 hours by a 7 day course of ampicillin, 500 mg QID. Tumor tissue and serum samples may be collected periodically for translational research. After completion of study treatment, patients are followed every 3 months for 2 years and then every 6 months for 3 years. As of January 31, 2014, enrollment has been completed in the 9 patient safety lead-in portion of the study and enrollment continues. Clinical trial information: NCT01266460.