tbuckley/cabot-search huggingface dataset:
Cytophilic immunoglobulin G binding on neutrophils from a child with malignant osteopetrosis who developed fatal acute respiratory distress mimicking transfusion‐related acute lung injury
Authors: Prema R. Madyastha, Elaine K. Jeter, L. Lyndon Key
Journal: American Journal of Hematology (1996)

A 16-month-old boy, diagnosed at age 3 months with osteopetrosis, was treated since age 6 months with rhlFN-γ in combination with rhM-CSF. The child developed acute respiratory distress within 1 hr of a paternal platelet transfusion. Both the child and the father were blood group type O, and platelets were collected the previous day from the father. Chest X-ray revealed right pulmonary consolidation and a complete “whiteout” on the left. By 24 hr, the lungs had the appearance of adult respiratory distress syndrome (ARDS). Over the course of the next 11 days, the child remained intubated and hypotensive, and died of respiratory insufficiency 11 days later. ARDS was confirmed at autopsy. Pre- and posttransfusion patient's sera, as well as paternal serum, were tested by granulocyte agglutination and flow cytometry against granulocytes (PMN) from the patient, father, mother, and routine cell-panel donors and lymphocytes for the presence of neutrophil-specific and lymphocyte (HLA) antibodies, to rule out classical transfusion-related acute lung injury (TRALI). Both the patient's and the paternal sera were devoid of antibodies, but the patient's neutrophils demonstrated strong binding of cytophilic IgG accompanied by extremely low serum IgG and IgG1 levels. Since rhlFN-γ is known to upregulate Fc gamma receptor type I (FcγRI) with high affinity for IgG1, the binding of cytophilic IgG suggests that the patient's neutrophils may have been activated in vivo. The case report of another child with osteopetrosis has also been described. Although the blood specimen was not available for serological studies, this 4½-year-old child treated with rhlFN-γ and rhM-CSF also died of adult respiratory distress syndrome, with similar clinical presentations. © 1996 Wiley-Liss, Inc.
Purulent Meningitis in Children: Review of 188 Observations
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Xenografts. Review of the literature and current status. Council on Scientific Affairs
Journal: JAMA (1985)

In response to growing public and legislative interest in organ transplantation, the American Medical Association's Council on Scientific Affairs has convened an advisory panel to prepare state-of-the-art monographs on several of the central topics. The first report of the panel, approved by the Council in February 1985, reviews the experimental work with xenografts. This report summarizes the published experience with animal and human xenografts to date and discusses the mechanisms of xenograft rejection. The report concludes that the process of xenograft rejection qualitatively resembles allograft rejection, involving both cellular and humoral immune mechanisms, but differs quantitatively depending on the genetic disparity between donor and recipient. Relative beneficial effects of various immunosuppression regimens, including cyclosporin on xenograft survival in donor recipient models with varying genetic disparity, have not yet been studied in a critical fashion.Presented here is the first report of an advisory panel on organ transplantation convened by the American Medical Association's Council on Scientific Affairs. This report, approved by the Council in February 1985, reviews experimental work with animal and human xenografts to date and discusses the mechanisms of xenograft rejection, which qualitatively resembles allograft rejection but differs quantitatively depending on the genetic disparity between donor and recipient. Major problems for research include histocompatibility barriers, mechanisms of graft rejection, development of adequate immunosuppressive agents, and investigation of possible infectious agents in animal organs that could be transmitted to human recipients. The report notes that xenografts could provide one approach for resolving organ procurement problems.
Hegele's Physicians' Account Record.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Nikhil Kapila, Asad Ur Rahman, Xaralambos B. Zervos
Journal: Hepatology (2020)

Potential conflict of interest: Nothing to report. We thank Drs. Terrault and Feld for their interest in our article. We agree that complications, both hepatic and extrahepatic, should be consistently reported to fully inform the transplant community. At our center, heart transplant (HT) recipients undergo per‐protocol biopsies, and liver (LT) and kidney (KT) transplant recipients undergo biopsy when there is a clinical indication. In our experience, no patients who underwent KT developed biopsy‐proven rejection. One patient who underwent LT developed acute cellular rejection that was managed with oral steroids. No HT patients developed clinically significant rejection. Posttransplant glomerulonephritis was observed in 1 patient who underwent KT, and no patients developed BK viremia. Although we agree that early initiation of direct‐acting antiviral (DAA) therapy should be the standard of care, we do not believe that prophylactic/preemptive DAA therapy is reproducible in the real world. Thus far, the majority of studies have been industry sponsored and therefore did not have to navigate the process of obtaining insurance approval for DAA therapy. We waited until after transplant to obtain insurance approval however alternative methods to ensure access to DAA therapy have recently been studied. Bethea et al (1) proposed a novel approach whereby study staff obtained insurance approval for DAA therapy before LT irrespective of whether they received a hepatitis C (HCV) viremic organ. Such an approach may be feasible and effective in ensuring prompt access to DAA therapy after transplant. As we gained experience with HCV viremic organs, our protocol adapted and treatment was initiated at shorter intervals after transplant. Despite the delay in starting DAA therapy, our results were similar to other studies, with all but 1 patient achieving sustained virological response. Two patients developed fibrosing cholestatic hepatitis (FCH), which may be attributable to a delay in the initiation of DAA therapy. FCH was associated with significant morbidity and mortality in the interferon era,(2) however DAA therapy is highly effective in managing FCH if recognized in a timely manner.(3) Although transplant centers must have a safety‐net system in place to provide treatment to patients in the rare instance that insurance providers do not approve treatment, expecting health care systems to cover DAA therapy at market cost(4) is unrealistic and may ultimately harm patients on the waitlist if centers avoid using allografts because of added cost. Working with payers and health care systems to ensure early access to DAA therapy is ultimately a strategy that is feasible and reproducible in the real world.
Cigarette sales to minors through vending machines
Authors: W. W. Reed
Journal: JAMA (1989)

<h3>To the Editor. —</h3> In the January 6, 1989, issue of JAMA there is a report entitled "Reducing the Illegal Sale of Cigarettes to Minors,"<sup>1</sup>which is based on a project organized by several individuals in Santa Clara County, California. The authors advocate the elimination of cigarette vending machines and allege that they play a significant role in smoking by minors. This allegation is based on questionable research methods and faulty conclusions and is totally inconsistent with long-established facts and available information. We believe that<i>JAMA</i>readers deserve to be informed about the true situation regarding the availability of cigarette machines to minors and the insignificant role they play in purchases by minors. The authors of the Santa Clara County report indicate that only 8% of cigarettes are sold through vending machines (the actual figure today is 5%). Even for this negligible market share there is convincing proof that
Highlights
Journal: JAMA Pediatrics (2017)

Abram and coauthors study the outcomes of 1520 delinquent youths 12 years after detention.Non-Hispanic white males had nearly 3 times the odds of educational attainment vs African American and Hispanic males, and 2 to 5 times the odds of gainful activity vs African American and Hispanic males.African American males fared the worst, with lives characterized by incarceration, criminal activity, and few positive outcomes.Sampson's Editorial describes the changes needed in the criminal justice system to break the stigma of a criminal record.
La Pielografia.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drugs
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Morbid Anatomy of Diabetic Neuropathy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Catheter ablation of idiopathic left ventricular tachycardia: Identification of target sites with and without late diastolic potential by entrainment mapping technique Tomoo Harada, Kazutaka Aonuma, Yasushi Tomita, Yasuhiro Yokoyama, Kiyoshi Nakazawa, Fumihiko Miyake, Fumio Suzuki. St. marianna University Toyoko Hospital, Kawasaki, Japan, Tokyo Medical and Dental University, Tokyo, Japan
Journal: Journal of the American College of Cardiology (2001)
Abstract 165: CUCDC2 regulates malignant phenotype of triple-negative breast cancer through interacting with â-catenin
Authors: Shuyan Han, Hai-Bo Han, Yan-Na Jiao, Pang-Kuo Lo, Yuan Yao, Qun Zhou, Ping-Ping Li
Journal: Cancer Research (2019)

Abstract Triple-negative breast cancer (TNBC) has the worst prognosis among all subtypes of breast cancer. CUE domain-containing protein-2 (CUEDC2) protein has reported to confer endocrine resistance in breast cancer by down-regulation of estrogen receptor α (ERα) expression. However, the function of CUEDC2 in TNBC subtype is unclear. Here, we showed CUEDC2 is expressed in triple-negative breast cancer and associated with its malignant phenotype. Knockdown of CUEDC2 not only inhibits TNBC cell proliferation, clone formation, migration, and invasion, but also suppresses TNBC stem cell mammosphere formation ability and cancer stem cell markers expression. While over-expression of CUEDC2 enhances its cell malignant phenotype. Furthermore, we determined that the ARM domain of β-catenin interacts with CUE domain of CUEDC2 through immunoprecipitation and pull-down assay. In the 34 TNBC samples, the expression levels of CUEDC2 and β-catenin also showed a positive correlation. Taken together, our study revealed CUEDC2 is associated with malignant phenotype and breast cancer stem cell properties of TNBC by interacting with β-catenin, and suggested that CUEDC2 may be a potential promising prognosis and therapy target for TNBC. Citation Format: Shuyan Han, Hai-Bo Han, Yan-Na Jiao, Pang-Kuo Lo, Yuan Yao, Qun Zhou, Ping-Ping Li. CUCDC2 regulates malignant phenotype of triple-negative breast cancer through interacting with â-catenin [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 165.
Can the human eye detect an offside position during a football match?
Journal: BMJ (2005)

In children with threadworm infection a course of mebendazole is useful.Antifungal creams usually have no place in the initial management of vulvovaginitis, since candida is an unlikely pathogen in prepubertal girls. 1 Girls with non-specific vulvovaginitis should be advised about hygienic measures-avoiding tight fitting clothing or other irritants such as harsh soaps to the vulva, front to back wiping after using the toilet, sitz baths, and protective ointments. 2 3For persistent or recurrent vulvovaginitis, an opinion from a gynaecologist to rule out a foreign body is traditionally recommended. 4 ConclusionsIn the management of vulvovaginitis in prepubertal girls current evidence suggests that, in addition to giving advice about hygienic measures, vaginal secretions should be obtained for microbiological investigations and that antibiotics should be used only if a pure or predominant growth of a pathogen is identified.This recommendation is based on one case-control study 1 and one retrospective study. 3However, there is little literature regarding the vaginal microflora of prepubertal children, and it is therefore difficult to determine whether bacteria isolated from patients' vaginal secretions are part of the normal microflora or are the cause of symptoms of vulvovaginitis.Of the existing studies on the microflora of the prepubertal vagina, many are flawed for lack of control subjects, and most combined prepubertal and peripubertal children, had small numbers, or lacked comprehensive cultures for a wide variety of micro-organisms.Clearly we need well designed, adequately powered, high quality studies to evaluate the vaginal microflora in asymptomatic prepubertal children and in those with symptoms of vulvovaginitis.
Drug Legalization, Harm Reduction, and Drug Policy
Authors: R L DuPont, E A Voth
Journal: Annals of Internal Medicine (1995)

The current U.S. policy options on drug use are reviewed in the context of the history of drug policy in the United States. A restrictive drug policy is a deterrent to drug use and helps reduce drug-related costs and societal problems. Although legalization or decriminalization of drugs might reduce some of the legal consequences of drug use, increased drug use would result in harmful consequences.
Isolated Intestinal Lactase Deficiency in the Adult
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastroenteritis
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recollections of the Medical School of Berlin
Authors: H. R. Swanzy
Journal: BMJ (1871)

not seem to exist among the Germans.After wintering in the south, they mostly go stolidly home, as a matter of course, and often remain sweltering during the dog-days at some watering-place on the Rhine or elsewhere.There they imbibe quantities of mineral waters in the midst of tropical heat, vainly hoping thereby to cure a vital cachexia, only to be arrested or cured by carrying out all the laws of physiology and hygiene, and that to their extreme development and limit.
Table of Contents
Authors: Gerald Murphy, Arthur Holleb, Lawrence Garfinkel, Margie Miller, Nina Clayton, Barbara Nakahara, Peter Castro, Yesenia Maldonado, Serena Stockwell, Vickie Thaw, Deborah Holmes, Lisa Desolis, Frank Cox, Ray Thibodeau, Martha Mcgarity, Emily Pualwan, Ted Gansler, Rosen Library, Jeff Clements, Gerald Woolam, John Kelly, John Seffrin, Harmon Eyre, Dileep Bal, Robert Young
Journal: CA A Cancer Journal for Clinicians (2000)