tbuckley/cabot-search huggingface dataset:
Pity the twisting tongue
Journal: JAMA (1968)

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American Journal of Psychiatry, Hanover, NH
Journal: JAMA (1970)

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The costs of HIV infections
Authors: Tony W. Cheung, Henry S. Sacks
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Arno et al<sup>1</sup>demonstrated the high cost of early intervention and treatment in human immunodeficiency virus disease. However, their cost estimate did not take into account recent results of AIDS [acquired immunodeficiency syndrome] Clinical Trial Group protocols or the recent reduction in the price of zidovudine. These studies demonstrated that zidovudine slowed the progression of human immunodeficiency virus infection in asymptomatic infection and early AIDS-related complex (ARC) and that lower doses appeared as effective as standard doses. Using these data, we suggest a different cost estimate in taking care of these patients. Based on a prospective study of 288 seropositive men in San Francisco, Calif,<sup>2</sup>and the survey of the Greater New York Hospital Association,<sup>3</sup>the ratio of ARC to AIDS is approximately 1:1. As of July 1989, the number of patients living with AIDS in the United States is 41000 (lower-bound estimate).<sup>4</sup>
Glue Sniffing
Authors: Sidney Cohen
Journal: JAMA (1975)

THE USE of industrial solvents and aerosol sprays to achieve an intoxicated state would seem an undesirable way to arrive at an alteration of consciousness. Nevertheless, a number of juveniles experiment with or habitually use these substances by inhalation. In some cities, the endemic abuse of model-airplane glue, paint thinner, gasoline, solvents, or propellants is well known. The volatile substances are generally aliphatic hydrocarbons, sometimes chlorinated or fluorinated. Inhalation provides rapid access to the brain via the lungs, assuring immediate onset of action and relatively short duration of effects. <h3>Classification</h3> Classification of solvents is difficult because household and commercial products may have unknown formulations, which need not be chemically pure. In addition, they may contain ingredients that are more toxic than the solvent itself. For example, habitual gasoline sniffing has resulted in lead poisoning. Aerosols may propel a spray of insecticide, furniture polish, or other noxious material. The number of
Sex and Gender Bias in Illustrations in Anatomy and Physical Diagnosis Texts
Authors: Merrilee R. Brandt
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Regarding the article by Ms Mendelsohn and colleagues,<sup>1</sup>the female authors quote that 8.8% of atlas illustrations other than those of reproductive organs were female. This means the subjects of 91.2% of the general illustrations were dead men. So, what's the problem?
INDOOR HUMIDITY.
Journal: JAMA (1904)

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<i>Announcement</i>: World Pneumonia Day — November 12, 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

November 12th marks the eighth annual World Pneumonia Day, observed to raise awareness of pneumonia as a global public health concern for persons of all ages and a leading infectious cause of death of children aged <5 years, causing approximately 900,000 child deaths annually (1). In the United States, the majority of the 53,000 annual pneumonia deaths occur in persons aged ≥65 years. Respiratory viruses, such as respiratory syncytial virus (RSV) and influenza, and Streptococcus pneumoniae bacteria are among the leading causes of pneumonia; RSV annually causes an average of 177,000 hospitalizations and 14,000 deaths in adults aged ≥65 years in the United States (1,2). In addition, approximately 5,000 cases of Legionnaires' disease occur each year in the United States, a 286% increase from 2000-2014; the case fatality rate is about 10% (1).
Pancreatitis due to mumps
Authors: C. L. Witte
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1970: Melatonin inhibits osteolytic bone metastasis through interrupting cancer cells-derived osteolytic factor and reduce osteoclast differentiation
Authors: Jyun-Lin Lai, An-Chen Chang, Po-Chun Chen, Chih-Hsin Tang
Journal: Cancer Research (2019)

Abstract Osteolytic bone metastasis is seen in lung, breast, and prostate cancer and is associated with severe complications such as bone pain, fractures and hypercalcemia. In the bone microenvironment, osteoclasts play an important role in bone remodeling and bone resorption. Metastatic cancer cells may increase osteoclast differentiation and activity by releasing inflammatory cytokines including receptor activator of nuclear factor kappa-B ligand (RANKL), tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and IL-8, leading to bone resorption and osteolytic lesions. The endogenous hormone melatonin is known to modulate bone resorption. Increasing evidence suggests that melatonin inhibits cancer cell proliferation, angiogenesis and metastasis. Up until now, the inhibitory role of melatonin in osteolytic bone metastasis has remained unclear. In In vitro study, we observed that melatonin inhibits the differentiation of precursor osteoclasts and promotes apoptosis in mature osteoclasts. We injected mice tibia with luciferase-labeled osteolytic cancer cell lines (lung cancer: A549, prostate cancer: PC-3) to establish bone metastasis. After 4 weeks of intraperitoneal injection with melatonin, IVIS fluorescence signaling indicated that melatonin inhibited tumor growth. X-ray imaging of the bone revealed an improvement in bone resorption after melatonin treatment. In In vitro melatonin also reduced RANKL protein and mRNA expression in the A549 and PC-3 cell lines. Our data indicate that melatonin improves bone mass by inhibiting the expression of cancer-derived osteolytic factors and by promoting apoptosis in mature osteoclasts. Our future investigations will seek to determine the signaling pathway involved in melatonin-regulated RANKL expression in cancer cells. In summary, our findings provide insight into the benefits of melatonin treatment in osteolytic bone metastasis. Citation Format: Jyun-Lin Lai, An-Chen Chang, Po-Chun Chen, Chih-Hsin Tang. Melatonin inhibits osteolytic bone metastasis through interrupting cancer cells-derived osteolytic factor and reduce osteoclast differentiation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1970.
Tuberculous Appendix
Authors: D. J. Harries, E. Williams
Journal: BMJ (1938)

TUBERCULOSIS IN INFANTSMEDICAL ITRNAL 277 hospital treatment, may result in cure even in such appar- ently dangerous cases (Plate, Fig. 2).Prognosis depends entirely on the stage at which diagnosis is arrived at, and thus every effort must be made to search out these cases and to recognize at a very early date the fact that they have been infected.The primary infection will show no clinical signs typical of the condition, and diag- nosis can only be made on the grounds already mentioned.Treatment First and mainly treatment consists in removal of infants from all possible tuberculous contact.They should not be put in sanatoria where there are cases of open phthisis.They should be taken to infant hospitals or preventoria, and the isolation must be maintained until healing is evidenced by ca1cification or by fibrosis.Calcification is the less usual end-result, because if infants have caseating foci there is nearly always a fatal termination.Fibrosis is the commoner end-result; and here in later radiographs nothing abnormal is seen, and the only proof of past infection is the serial radiographs and a positive tuberculin test.Healing is established in mild cases in six months, but other cases may take up to two years.The falling of the sedimentation rate to normal also indicates healing.The second essential of treatment is rest in bed.Move- ments in the cot have to be permitted, but exercise out of the cot must be postponed until serial radiographs and normal sedimentation rate and weight gain show that the lung is healed.Fresh air is essential throughout treat- ment, but infants must not be exposed beyond their limits of endurance, and throughout treatment they must be kept warm.Digestive disturbances must be attended to and a suitable diet rich in vitamins, with added calcium, must be given.Ultra-violet rays and strong sunshine are absolutely contraindicated in all pulmonary lesions in infants and children; however, in these climates outdoor shade in summer and exposure to sun in spring and autumn are safe.Temperature charts, the sedimentation rate, and radiographs all demonstrate how dangerous is sun-bathing to a small child with a pulmonary lesion, be this only in the primary stage.It will be found that casualties occurring during the primary stage of pul- monary tuberculosis will be among those infants whose parents are not convinced, and who do not allow this treatment to be carried on until complete healing has been ensured.Summary 1. Seventy-eight cases of tuberculosis of the lungs are reported in infants under 1 year old: 23 per cent.recovered.2. Healing can only be achieved by early diagnosis- that is, in the primary stage.3. Early diagnosis can only be made by tuberculin skin test, radiography, and history of contact.4. Treatment consists mainly in immediate removal from contact and in rest.
"NEPHRITIS IN CHILDHOOD"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE WHITE HOUSE CONFERENCE ON CHILD WELFARE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatocyte-targeted R-spondin mimetic for liver regeneration
Authors: Zhengjianzhang Zhang, Caroline Broderick, Marni Shimoto, Teppei Yamaguchi, Sung-Jin Lee, Zhong Wang, Haili Zhang, Hui Chen, Jay Ye, Helene Baribault, Wen-Chen Yeh, Yang Li
Journal: Journal of Hepatology (2020)
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Kevin Brown, Amanda Ehrhardt, Iris Lo, Michaela Mark, M Newman, Suzanne Walker, Connie Manno, Sara Billings, Timothy Gray, Paul Ruich, Catherine Copyreaders, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Joseph King, Brandy Mills, Donna Patton, Editorial Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Fanny Brown, Anna Bukowski, Lenette Gardner-Gullens, Tosca Hall, Erin Kato, Peter Kim, Rachell Lozano, Caroline Sietmann, Angelia Waltower, Michael Berkwits, Eric Butkus, Michelle Kurzynski, Emily Ling, Jesse Mcquarters, Daniel Morrow, Daniella Peting, Reuben Rios, Carrie Butt, Mary Ferkaluk, Ronna Henry, Karen Bucher, Andy Rekito, Nick Reback, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Managers, Fergus Clare, Lindsay Dawson, Will English, Ellen Gibson, Mustafa Ishaq, Peter Litton, Craig Mccaff Rey, Michael Mcgraw, Jon Perkins, Daniel Pickhardt, Romando Rossini, Sarah Subramanian, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Tom Miller, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Jordynn Farrar, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Binita Shah, Erin Spencer, Denise Steinhauser, Joe Advertising, Production Services, Ahmed Avendano, Kim Boler, Rhonda Brown, Jennifer Carney, Fin Carter, Michael Deegan, Daniel Degroot, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Joshua Lampinen, Nathan Mitre, Patricia Panek, Marla Seidell, La Son Diggs, Joe Amft, James Collver, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Constance Murphy, Martin Paulus, Christine Konradi, Helena Chmura Kraemer, Palo Alto, Howard Bauchner, Dost Ongür
Journal: JAMA Psychiatry (2018)
Abstract 734: Large-scale radiogenomic profiling of patient derived xenografts (PDX)
Authors: Priyanka Gopal, Titas Bera, Craig Peacock, Mohamed Abazeed
Journal: Cancer Research (2019)

Abstract The determinants of clinical failure after radiotherapy remains poorly understood. Although cancer derived cells grown in vitro have served as a valuable resource to identify tumor cell intrinsic determinants of radiation sensitivity, their propensity to undergo genetic selection due to non-native culture conditions reduces intratumoral heterogeneity and alters transcriptomic fidelity. We show that patient-derived xenografts (PDX) models recapitulate the genetic and transcriptomic features of the primary tumors from which they are derived. We extend this characterization to an extensive collection of PDXs derived from multiple cancer types. We propose our “10,000 mice” PDX effort, which seeks to profile up to 500 PDX across 20 cancer types with multiple single fraction doses of radiation (2, 4, 6, 8, 10 Gy). We establish the feasibility of our approach using a 3x1x1 experimental design (3 mice per PDX per dose of radiation). Initial treatment responses following single doses radiation revealed that tumors exhibit significant variation in their response to radiation. Responses in PDX correlated with clinical outcomes, mainly in patients treated with radiation or chemoradiation alone. We compare pre- and post-irradiation PDX and deoncstruct the phylogenetic architecture of tumors before and after treatment selection. We show that in a substantial proportion of the tumors profiled to date, treatment resistance is regulated by subclonal outgrowths. Taken together, our results demonstrate the feasibility of high-content profiling of PDX to identify determinants of radiation sensitivity. Note: This abstract was not presented at the meeting. Citation Format: Priyanka Gopal, Titas Bera, Craig Peacock, Mohamed Abazeed. Large-scale radiogenomic profiling of patient derived xenografts (PDX) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 734.
MEDICAL HISTORY.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sir Hans Sloane (1660-1753) Founder of the British Museum
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal