Lupoid Hepatitis
Authors: TELFER B. REYNOLDS
Journal: Annals of Internal Medicine (1964)

Article1 October 1964Lupoid HepatitisTELFER B. REYNOLDS, M.D., F.A.C.P., HUGH A. EDMONDSON, M.D., F.A.C.P., ROBERT L. PETERS, M.D., ALLAN REDEKER, M.D.TELFER B. REYNOLDS, M.D., F.A.C.P.Search for more papers by this author, HUGH A. EDMONDSON, M.D., F.A.C.P.Search for more papers by this author, ROBERT L. PETERS, M.D.Search for more papers by this author, ALLAN REDEKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-650 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1956, Bearn, Kunkel, and Slater (1) called attention to a form of chronic liver disease in young women that is characterized by coarsely nodular cirrhosis, marked hypergammaglobulinemia, and episodes of arthralgia. One of their patients had a positive lupus erythematosus (LE) test. In 1955 and 1956, there were reports of similar cases with positive LE tests from Joske and King (2), Bettley (3), and Heller, Zimmerman, Rozengvaig, and Singer (4). Mackay, Taft, and Cowling (5) coined the term "lupoid hepatitis" in 1956 to describe such patients with chronic liver disease and positive LE cell preparations. Additional cases have been...References1. BEARNKUNKELSLATER AGHGRJ: The problem of chronic liver disease in young women. Amer. J. Med. 21: 3, 1956. CrossrefMedlineGoogle Scholar2. JOSKEKING RAWE: The LE cell phenomenon in active chronic viral hepatitis. Lancet 2: 477, 1955. CrossrefGoogle Scholar3. BETTLEY FR: The "LE cell" phenomenon in active chronic viral hepatitis. Lancet 2: 724, 1955. CrossrefGoogle Scholar4. HELLERZIMMERMANROZENVAIGSINGER PHFSK: The LE cell phenomenon in chronic hepatic disease. New Eng. J. Med. 254: 1160, 1956. CrossrefMedlineGoogle Scholar5. MACKAYTAFTCOWLING IRLIDC: Lupoid hepatitis. Lancet 2: 1323, 1956. CrossrefGoogle Scholar6. BARTHOLOMEWHAGEDORNCAINBAGENSTOSS LGABJCAB: Hepatitis and cirrhosis in women with positive clot tests for lupus erythematosus. New Eng. J. Med. 259: 947, 1958. CrossrefMedlineGoogle Scholar7. ARONSONMONTGOMERY ARMM: Chronic liver disease with a "lupus erythematosuslike syndrome." Arch. Intern. Med. (Chicago) 104: 544, 1959. CrossrefMedlineGoogle Scholar8. WILKINSONSACKER MLS: The lupus erythematosus cell and its significance. Brit. Med. J. 2: 661, 1957. CrossrefMedlineGoogle Scholar9. PAGEGOOD ARRA: Plasma-cell hepatitis with special attention to steroid therapy. Amer. J. Dis. Child. 99: 288, 1960. Google Scholar10. FISCHER DA: The "lupoid hepatitis" syndrome: report of a case followed by serial liver biopsies. Ann. Intern. Med. 57: 988, 1962. LinkGoogle Scholar11. MACKAYWOOD IRIJ: Lupoid hepatitis: a comparison of 22 cases with other types of chronic liver disease. Quart. J. Med. 31: 485, 1962. Google Scholar12. TISDALE WA: Subacute hepatitis. New Eng. J. Med. 268: 138, 1963. CrossrefMedlineGoogle Scholar13. JONESCASTLEMAN WAB: Liver disease in young women with hyperglobulinemia. Amer. J. Path. 40: 315, 1962. MedlineGoogle Scholar14. ZINKHAMCONLEY WHCL: Some factors influencing the formation of LE cells. Bull. Hopkins Hosp. 98: 102, 1956. MedlineGoogle Scholar15. KRUPP MA: Urinary sediment in visceral angiitis (periarteritis nodosa, lupus erythematosus, Libman-Sacks "disease"); quantitative studies. Arch. Intern. Med. (Chicago) 71: 54, 1943. CrossrefGoogle Scholar16. MACKAYTAFTCOWLING IRLTDC: Lupoid hepatitis and the hepatic lesions of systemic lupus erythematosus. Lancet 1: 65, 1959. CrossrefMedlineGoogle Scholar17. REDEKERREYNOLDSKUZMA AGTBOT: The effect of cortisone on SGOT and SGPT levels in acute viral hepatitis. Gastroenterology 40: 560, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, CaliforniaFrom the Departments of Medicine and Pathology at the University of Southern California School of Medicine, Los Angeles, and the Los Angeles and John Wesley County Hospitals, Los Angeles, California.This work was supported in part by grant AM-05801 from the National Institutes of Health, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to TeIfer B. Reynolds, M.D., Professor of Medicine, Department of Medicine, University of California School of Medicine, 2025 Zonal Avenue, Los Angeles, Calif. 90033. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGastrointestinalLa historia de las enfermedades órgano-específicas. 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CELL TEST AND LUPUS NEPHRITISClassification and Treatment of Chronic Active Liver DiseaseNATURAL HISTORY OF ACTIVE CHRONIC HEPATITISNATURAL HISTORY OF ACTIVE CHRONIC HEPATITISEffect of corticosteroid therapy on bromsulphthalein excretion in active chronic hepatitis.Chronic Active Hepatitis with Lupus NephritisE. JACK BENNER, M.D., RICHARD T. GOURLEY, M.D., ROBERT A. COOPER JR., M.D., JOHN A. BENSON JR., M.D.THE TREATMENT OF ACTIVE CHRONIC HEPATITIS WITH 6-MERCAPTOPURINE AND AZATHIOPRINEVirushepatitisVirushepatitis“Auto-immune” Chronic HepatitisIMMUNOGLOBULINS IN VIRAL HEPATITIS AND ACTIVE ALCOHOLIC LIVER-DISEASELupoid Hepatitis 1 October 1964Volume 61, Issue 4Page: 650-666KeywordsChronic liver diseaseCirrhosisHepatitisHypergammaglobulinemiaHyperglobulinemiaLupus erythematosusMedical servicesNecrosisNeutrophilsPrevention, policy, and public health Issue Published: 1 October 1964 PDF DownloadLoading ...