tbuckley/cabot-search huggingface dataset:
Warm up
Journal: British Journal of Sports Medicine (2001)

Warm upJust back from the American College of Sports Medicine (ACSM) meeting in Baltimore.The meeting once again lived up to its pre-conference hype.To attend such a conference is an eye opener.Every young sports medicine practitioner should make the eVort at least once.I am sure the Americans must have some supercomputer tucked away to deal with a meeting matrix of such complexity that requires 25 concurrent sessions running at any one time.The highlight was probably the presidential keynote address on the history of medicine in space.Using more computer technology than the Apollo 11 moon landing, this talk dazzled the audience with three simultaneous data projectors, movie animation, voice overs, and sound bites from the music of the era.I pity the person designated to give the keynote at the next meeting in St Louis.How could you possibly top that performance?One pleasing aspect is the ever increasing non-American contingent that attends this meeting.Compared with my first ACSM conference more than 10 years ago, the change is spectacular.I can well remember in Dallas (ACSM 1992) only two sports medicine clinicians from Australia preaching to the masses of sceptical Americans.I seriously believe that they thought we were actually from Austria and were surprised that we spoke English!Now the non-American attendees number in the thousands.It is increasingly obvious that as more of the sports medicine organisations from around the world sponsor lectures and symposiums at this meeting, so the Americans are introduced to ideas and concepts that challenge their insular view of the world.This can only be to the advantage of all.It was impressive to see that the British Association of Sport and Exercise Medicine lecture this year was
Erratum
Journal: BMJ (1927)

auy record in any textbook " of toxic symptoms produced by the drug.May 1, therefore, draw attention to Professor Glaister's Medical Jurisprudence acnd Toxicology (fourth edition, p. 821) ?There two cases (one fatal) of poisotning by eucalyptts oil are described in full.The early signs and symptoms in these cases appear to have been similar to those in Dr. Gibbin's-except that in each case the pulse is fast.Glaister also mentions two cases of this poisoning seen by Kirkuess. INCOME TAX.Expentse Attached to Appointment.A FULL-TIME lecturer in anatomy states that one of the terms of his appointment was that he was " expected to engage in higher study and research."He has claimed to deduct the expense of visiting meetings of the Anatomical Society to exhibit his restults; those expenses have beeu disregarded, as also the expense entailed in applyinlg for better appointments.*** We agree that the terms used imply as a binding legal conldition that the research work shall be done, and that the expense of attending the m-eetings is allowable if that is similarly enjoined, either expressly or by implication.'Thecost-of applying
Neonatal Seizures
Authors: Joseph Volpe
Journal: New England Journal of Medicine (1973)

SEIZURES are a frequent and often dramatic occurrence in the neonatal period. Unlike the situation with older infants, neonatal seizures do not usually represent a medical emergency, since the convulsive activity in the neonate very uncommonly interferes to any great extent with respiratory activity. Nevertheless, it is critical to determine the cause of the spells rapidly and to treat them, since they often reflect serious illness.Clinical FeaturesSeizure types in newborn infants differ considerably from those observed in older infants, and the types in premature infants differ from those in full-term neonates. Unlike older infants, newborn infants rarely have . . .
Combination therapy with gefitinib (ZD1839) and rofecoxib in platinum-pretreated relapsed non-small-cell lung cancer (NSCLC)
Authors: K. O'Byrne, L. Clarke, D. Dunlop, M. Ranson, S. Danson, N. Botwood, D. Carbone
Journal: Journal of Clinical Oncology (2004)

7101
The relationship between lupus anticoagulants and antibodies to phospholipid
Authors: D. A. Triplett
Journal: JAMA (1988)

The relationship between lupus anticoagulants and antibodies directed against negatively charged phospholipids, as measured by an enzyme-linked immunosorbent assay, was explored in a series of plasma samples from 100 patients with well-characterized lupus anticoagulants. Only 73% of the patients had detectable IgG, IgM antibodies, or both, to one or more of four phospholipids. Of these patients, 29% had IgG-type antibodies only, 56% had both IgG and IgM antibodies, and 15% had IgM antibodies only. Of the 100 patients, 19% had a history of thrombosis, 8% had a history of spontaneous abortion, and 6% had a history of seizure disorder. These complications occurred in the presence (80%) and absence (20%) of detectable antiphospholipid antibodies. Drug-related antibodies were observed in 34 patients; of these, 71% had detectable antiphospholipid antibodies and 24% had a history of thrombosis. There were ten patients with lupus anticoagulants associated with infections; none of these patients had a history of thrombosis. The results indicate that antiphospholipid antibodies are not present in all patients with lupus anticoagulants, that the presence of antiphospholipid antibodies in patients with lupus anticoagulants does not increase the risk of thrombosis in these patients, and that drug-related antibodies are associated with an increased risk of thrombosis. Lupus anticoagulants and antiphospholipid antibodies seem to define two distinct but related patient populations, each associated with an increased risk of thrombosis. (<i>JAMA</i>1988;259:550-554)
Emergency medicine
Authors: W. G. Barsan
Journal: JAMA (1991)

Cardiac and brain resuscitation have continued to be dominant areas for research in 1990. The spectacular failure of cardiopulmonary resuscitation to successfully resuscitate all but a small minority of patients has motivated a number of investigations on the method of performance of advanced cardiac life support. Animal studies have demonstrated that the empiric dosage of epinephrine in cardiac arrest may be inadequate to produce sufficient cardiac and cerebral perfusion pressures during cardiopulmonary resuscitation and that larger doses may be more successful. Human studies show that the coronary perfusion pressure achieved during cardiopulmonary resuscitation is the most important predictor of successful resuscitation.<sup>1</sup>Paradis et al<sup>1</sup>studied 100 patients in cardiac arrest to determine the relationship of coronary perfusion pressure to return of spontaneous circulation. No patients with a coronary perfusion pressure of less than 15 mm Hg had return of spontaneous circulation. Arterial blood gas values had a poor
Relative macrocytosis in cyclophosphamide and azathioprine therapy
Authors: J. H. Klippel
Journal: JAMA (1974)

A relative increase in erythrocyte volume is observed in patients who have connective tissue diseases and who are treated with cyclophosphamide and azathioprine. Hemoglobin loss correlates with the magnitude of the volume increase. (<i>JAMA</i>229:180-181, 1974)
Errata
Authors: Da Macatatstbhas, P Bassett-Smith, W Foy, J Guinness, R Johnson, D Kalapesi, A Mackino, W Foxell, M Fiest, Physic8.-O Alrth, L Hudson, J Chemistry, Physies.-Harriet &pps, W Barkes, J Beatty, B Campbell, P Gabe, C Galnin, J Gray, E Jackson, Ruth Martin, T Nicholson, R Feel, H Raffle, G Sykes, Biology -F Wood, H Ware, Theresa Macgregor, L De Gournay Miller, Dorothea Stewart, Tudor Mary, M Anatomy, Materia Medica, C Saint, H Davison, F Ktobinson, K Aii&d, C Brown, I Flosgkinson, E Hughes, F Kellgreo, C Melvin, F Neilan, B Rahtkens, E Taylor, ] W&dd, M Ngton, Fedical Pathologsv, Public Jurf8prudenee, H Levison, L2st.-H Pass, G Blake, G Davis, Elizabeth Ellis, H Havelock, E Joynt, C Joynt, Jessie Kemp, E Murray, W Markbam, J Trolin, L Smith, G Walker, J Goodfellow, E Clarke, W Rainsbury, W Ransom-L, W Duncar, G Sootb, Messrs Mackie, A Filcher, H Metcher, V Sutcliffe, A Shea, C Findlay, H Sykes, Mediciie.-M Boileau, J Lyneb, R Verity, Medicine.-M Forensc, C Boileau, T Grey, S Johnston, J Johnston, R Sykes
Journal: BMJ (1905)

Tratisfer Commissioners giva notice that they have made an order appointing September ist, igo6.as the appointed day under the said Act enuerally, but without prejudice
State-Specific Influenza Vaccination Coverage Among Adults—United States, 2006-07 Influenza Season
Journal: JAMA (2008)

Adult groups included in the 2008 Advisory Committee on Immunization Practices (ACIP) recommendation for annual influenza vaccination include all persons aged >/=50 years, women who will be pregnant during the influenza season, persons aged 18-49 years with high-risk conditions, and other persons at increased risk for complications from influenza. Health-care personnel and household contacts and caregivers of persons at high risk also should receive annual influenza vaccination, as should adults who want to reduce their risk for becoming ill with influenza or for transmitting it to others. Healthy People 2010 influenza vaccination coverage targets are 90% among all persons aged >/=65 years and 60% among persons aged 18-64 years who have one or more high-risk conditions. Data from the 2006 and 2007 Behavioral Risk Factor Surveillance System (BRFSS) surveys indicate that influenza vaccination coverage among adults for the 2006-07 season increased significantly compared with the 2005-06 season, reaching 35.1% among persons aged 18-49 years with high-risk conditions, 42.0% among all persons aged 50-64 years, and 72.1% among all persons aged >/=65 years. However, vaccination coverage remained well below Healthy People 2010 targets. Increasing influenza vaccination coverage among adults in the United States will require more cooperation among health-care providers, professional organizations, vaccine manufacturers, and public health departments to raise public awareness about influenza vaccination and to ensure continued distribution and administration of available vaccine throughout the vaccination season.
ERRATUM
Journal: Environmental Health Perspectives (2008)

Main et al. (2007) reported that elevated levels of polybrominated diphenyl ethers (PBDEs) in breast milk, but not placenta, were associated with congenital cryptorchidism in Danish and Finnish boys.For the Danish cohort, the researchers used a case-cohort design in which biological samples were collected from all study participants, whereas for the Finnish cohort, they used a nested case-control design.The matching criteria used for Finnish mothers who gave birth to boys with cryptorchidism (measured at birth) and matched Finnish controls included the following: parity, smoking (yes/no), diabetes (yes/no), gestational age (± 7 days), and date of birth (± 14 days).However, Main et al. (2007) did not provide information on adjustments made to account for the type/severity of diabetes (Virtanen et al. 2006), smoking habits (Kurahashi et al. 2005), alcohol consumption (Damgaard et al. 2007), cesarean section (Hjertkvist et al. 1989;Kurahashi et al. 2005), and other factors that may be associated with cryptorchidism.Interestingly, Main et al. did note that approximately 12% and 18% of breast milk samples and placentas, respectively, were obtained from diabetic Finnish mothers of cryptorchid boys, compared with 0% of controls (Main et al. 2007), but they conducted no further inquiry on this discrepancy.Damgaard et al. (2007) previously evaluated this same Danish-Finnish cohort and adjusted for confounders and effect modifiers for differences observed based on country, smoking, caffeine intake, alcohol consumption (including binge-drinking episodes), social class, maternal age, parity, maturity, and birth weight.Damgaard et al. (2007) noted an association between maternal alcohol consumption (≥ 5 drinks/week) and transient cryptorchidism.Despite these findings, Main et al. (2007) provided no information on stratified alcohol consumption or other potential confounders, such as caffeine intake or social class.Main et al. (2007) concluded that an association exists between PBDE levels in breast milk and cryptorchidism in boys, but we should be cautious of this interpretation, given that Main et al. (2007) may not have adequately addressed potential confounders.
Gender and survival benefit from initial irinotecan in metastatic colorectal cancer: Analysis of the XELAVIRI (AIOKRK0110) study.
Authors: Kathrin Heinrich, Dominik Paul Modest, Ingrid Ricard, Ludwig Fischer von Weikersthal, Thomas Decker, Ursula Vehling-Kaiser, Ullrich Graeven, Jens Uhlig, Michael Schenk, Jens Freiberg-Richter, Bettina Peuser, Claudio Denzlinger, Christina Peveling genannt Reddemann, Clemens Giessen-Jung, Arndt Stahler, Swantje Held, Andreas Jung, Thomas Kirchner, Sebastian Stintzing, Volker Heinemann
Journal: Journal of Clinical Oncology (2019)

3559 Background: XELAVIRI compared initial vs sequential irinotecan (iri) in combination with fluoropyrimidine (FP) plus bevacizumab (bev) in patients (pts) with mCRC, trial identification: NCT01249638. In the full analysis set of the study, non-inferiority of time to failure of strategy (TFS) was not shown (primary endpoint). Pts with RAS/BRAF wildtype (wt) tumors benefitted from initial iri. Methods: The study endpoints objective response rate (ORR), progression-free survival (PFS), time to failure of strategy (TFS) as well as overall survival (OS) were evaluated in female vs. male pts as well as molecular subgroups (i.e. RAS mutational status). Interaction of treatment and gender was tested by likelihood ratio tests. Results: Of 421 patients, 281/140 were male/female. In male patients, ORR was 33.6% without and 58.3% with initial iri (P &lt; 0.001). PFS (HR: 0.54 (95%CI 0.42-0.69) P &lt; 0.001) and OS (HR: 0.63 (95%CI 0.47-0.85), P = 0.002), were also significantly better with initial iri. In the subgroup analysis, this effect was especially pronounced in pts with RAS/BRAF wt tumors. In female pts, ORR was 43% in both arms, PFS was similar (HR: 1.09 (95%CI 0.76-1.55), P = 0.65) without and with initial iri. In OS, a strong trend for inferior outcome with initial iri was seen (HR: 1.46 (95%CI 0.95-2.24), P = 0.08) that reached significance in the multivariate analysis (HR: 1.73 (95%CI 1.04-2.86, P = 0.034). Female patients with RAS/BRAF wt tumors did not benefit from initial iri (HR 1.05 (95% CI 0.46-2.41), P = 0.903 for OS). Formal interaction of treatment and gender was seen for ORR (P = 0.018), PFS (P = 0.002) and OS (P = 0.001). There were some trends for more pronounced toxicities in female pts treated with Irinotecan. Conclusions: This unplanned exploratory analysis suggests that gender might interact with efficacy of initial iri when used in the context of FP and bev. While especially male RAS wild-type patients derived a significant and clinically meaningful benefit from initial use of iri, this was not observed in female patients with RAS wt tumors. Clinical trial information: NCT01249638.
PROPHYLAXIS OF CHOLERA—RAPID DISINFECTION.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nucleotide Therapy in Agranulocytosis
Journal: Journal of Clinical Investigation (1930)

Artide by Paul Resnikoff, "Nudleotide Therapy in Agranulocytosis" Page 381, footnote to be appended: Dr. Henry Jackson, Jr. suggests to me that the compounds adenine sulfate and guanine hydrochloride should not be called nucleotides but purine salts derived from nucleotides.The work of Doan quoted in this article was carried out with nucleotides containing these purines.
Osleriana
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ARTIFICIAL PNEUMOTHORAX IN FRACTURED RIBS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Problems are for solving
Authors: W. C. Bornemeier
Journal: JAMA (1972)

Among the problems that beset the medical profession, I shall consider the following: The number of doctors—in many areas, no doctor. The supply of family physicians—only 22% of doctors are generalists, mostly in older age groups. Maldistribution—even the rural rich and many affluent neighborhoods face scarcities. The hospital outpatient department as a primary care center at night and on weekends. The disproportion between specialty training programs, medical graduates, and community needs. Compensation of interns and residents. What are the solutions and what is being done? Almost four years ago, the American Medical Association, recognizing that a 7,500 doctor gain per year was not enough, held a meeting with the officers of the Association of American Medical Colleges. From that meeting came a statement that medical school enrollment should be increased to the point where every qualified applicant could be admitted. At that time there
Utility of Different Lipid Measures to Predict Coronary Heart Disease
Authors: Justo Sierra-Johnson, Abel Romero-Corral, Francisco Lopez-Jimenez
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disposal of low-level radioactive waste. Problems and implications for physicians
Authors: W. R. Hendee
Journal: JAMA (1993)

RADIOACTIVE waste is categorized into high-level waste, including spent reactor fuel and waste from defense installations, and low-level waste generated principally by utilities, industry, clinical and research institutions, and government agencies. Low-level radioactive waste contains only small quantities of radioactivity. It includes items such as contaminated gloves and protective clothing; glass and plastic laboratory supplies; machine parts and tools; syringes, filters, and lightly radioactive equipment; and waste products from animal housing, radiopharmaceutical preparation facilities, and reactor coolingwater cleanup systems. It does not include transuranic elements, spent fuel from nuclear power plants, or high-level radioactive waste of any form. The disposal of low-level radioactive waste has been a controversial issue in the United States for more than two decades. Initial efforts to resolve this controversy for waste produced in the civilian sector led to congressional passage of the Low-Level Radioactive Waste Policy Act of 1980,<sup>1</sup>followed by a major amendment