tbuckley/cabot-search huggingface dataset:
SOCS2 negatively regulates growth hormone action in vitro and in vivo
Authors: Christopher J. Greenhalgh, Elizabeth Rico-Bautista, Mattias Lorentzon, Anne L. Thaus, Phillip O. Morgan, Tracy A. Willson, Panagiota Zervoudakis, Donald Metcalf, Ian Street, Nicos A. Nicola, Andrew D. Nash, Louis J. Fabri, Gunnar Norstedt, Claes Ohlsson, Amilcar Flores-Morales, Warren S. Alexander, Douglas J. Hilton
Journal: Journal of Clinical Investigation (2005)

Mice deficient in SOCS2 display an excessive growth phenotype characterized by a 30–50% increase in mature body size. Here we show that the SOCS2–/– phenotype is dependent upon the presence of endogenous growth hormone (GH) and that treatment with exogenous GH induced excessive growth in mice lacking both endogenous GH and SOCS2. This was reflected in terms of overall body weight, body and bone lengths, and the weight of internal organs and tissues. A heightened response to GH was also measured by examining GH-responsive genes expressed in the liver after exogenous GH administration. To further understand the link between SOCS2 and the GH-signaling cascade, we investigated the nature of these interactions using structure/function and biochemical interaction studies. Analysis of the 3 structural motifs of the SOCS2 molecule revealed that each plays a crucial role in SOCS2 function, with the conserved SOCS-box motif being essential for all inhibitory function. SOCS2 was found to bind 2 phosphorylated tyrosines on the GH receptor, and mutational analysis of these amino acids showed that both were essential for SOCS2 function. Together, the data provide clear evidence that SOCS2 is a negative regulator of GH signaling.
THE BRITISH MEDICAL ASSOCIATION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone Sarcoma. An Interpretation of the Nomenclature used by the Committee on the Registry of Bone Sarcoma of the American College of Surgeons.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Influenza Activity — United States, October 4, 2015–February 6, 2016
Authors: Kate Russell, Lenee Blanton, Krista Kniss, Desiree Mustaquim, Sophie Smith, Jessica Cohen, Shikha Garg, Brendan Flannery, Alicia M. Fry, Lisa A. Grohskopf, Joseph Bresee, Teresa Wallis, Wendy Sessions, Rebecca Garten, Xiyan Xu, Anwar Isa Abd Elal, Larisa Gubareva, John Barnes, David E. Wentworth, Erin Burns, Jacqueline Katz, Daniel Jernigan, Lynnette Brammer
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

From October through mid-December 2015, influenza activity remained low in most regions of the United States. Activity began to increase in late December 2015 and continued to increase slowly through early February 2016. Influenza A viruses have been most frequently identified, with influenza A (H3N2) viruses predominating during October until early December, and influenza A (H1N1)pdm09 viruses predominating from mid-December until early February. Most of the influenza viruses characterized during that time are antigenically similar to vaccine virus strains recommended for inclusion in the 2015-16 Northern Hemisphere vaccines. This report summarizes U.S. influenza activity* during October 4, 2015-February 6, 2016, and updates the previous summary (1).
Miscellany.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 609: Vitamin D binding protein and risk of renal cell carcinoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Authors: Tyler B. Kratzer, Alison M. Mondul, Stephanie J. Weinstein, Demetrius Albanes
Journal: Cancer Research (2019)

Abstract Introduction/Study purpose: Vitamin D binding protein (DBP) is the major carrier of vitamin D in circulation. In addition to its role in vitamin D transport, DBP has several other biologic mechanisms that may be relevant to cancer risk including macrophage activation, apoptosis, and angiogenesis. Although previous studies have demonstrated no association between vitamin D and RCC, our group has conducted two previous studies which found strong inverse associations between DBP and RCC. We undertook the current analysis to replicate our findings in a different study population. Methods: We conducted a nested case-control study in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Cases (n=323) were matched 1:1 to controls on age (+/- 1 year), race, date of blood collection (+/- 30 days) and sex. We performed conditional logistic regression to estimate the odds ratios and 95% confidence intervals for the association between quartiles of circulating DBP and risk of RCC. In addition to conditioning on the matching factors, multivariable models were further adjusted for history of diabetes or hypertension, family history of renal cancer, body mass index (BMI), and smoking status. Additionally, we performed stratified analyses by sex, family history of renal cancer, BMI, smoking status, and tumor stage at diagnosis. Results: We observed a statistically significant positive association between DBP and RCC that persisted after multivariable adjustment (mv-adj Q4 vs. Q1 OR=3.1, 95% CI=1.8-5.6; p-trend &amp;lt;0.0001). Sensitivity analyses were performed removing matched pairs where the case was diagnosed within 2 years of blood collection or experienced a large weight loss (&amp;gt;40 lbs), with little effect on the overall trend (Q4 vs. Q1 OR=2.5 CI=1.4-4.6 p-trend=&amp;lt;0.0001). Conclusions: In the present study, those with higher serum concentrations of DBP were at increased risk of RCC, which differs from previously-published findings. Further research is necessary to determine the true association between DBP and risk of RCC, and whether different DBP phenotypes via GC variation may have different associations with risk of RCC. Note: This abstract was not presented at the meeting. Citation Format: Tyler B. Kratzer, Alison M. Mondul, Stephanie J. Weinstein, Demetrius Albanes. Vitamin D binding protein and risk of renal cell carcinoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 609.
TYPHOID FEVER IN DETROIT
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases Associated with Immunosuppression
Authors: Eugene R. Heise
Journal: Environmental Health Perspectives (1982)

Impairment of any of the major components of the immune system (T-cells, B-cells phagocytes, complement) may result in clinical immunodeficiency. Immune defects can arise from intrinsic or heritable defects of lymphoid elements, failure of normal cellular differentiation, viral infection or other acquired causes. Clinical impairment of immunity is expressed as a marked susceptibility to opportunistic and pathogenic organisms which are difficult to control and by an increased risk of malignancy, allergy and autoimmune disease. Certain immunodeficiency disorders are associated with aberrant immune regulation. The major types of immune deficiency are characterized by unique patterns of infections depending on the level at which the defect occurs and the pathogenic mechanisms of the parasite. The basic defects of representative primary and secondary immunodeficiencies are discussed in relation to observed immunologic consequences.
Editorial Board
Authors: Paul Henkind, New York, Joseph Walsh, N Editoi\ial, Mathea Allansmith, David Guyton, M Baltimore, Jersome Bettman, Frederick Jakobiec, Ronald Burd, Robert Machemer, St Louis, M Durham, Richard Einaugler, Robert Stamper, Saeid Abedin, Richard Simmons, W Grant, Robert Jackson, Carl Ide, Richard Guthrie, Ronald James, Gary Brown, Larry Magargal, Jay Federman, Jerry Shields, Brian Altman, Harold Koller, Norman Jaffe, Henry Clayman, Mark Jaffe, Manus Kraff, Donald Sanders, Howard Lieberman, Thomas Beardsley, Gary Foulks, Enrique Malbran, Roberto Fernandez-Meijide, John Purcell, Jay Krachmer, Donald Doughman, William Bourne
Journal: Ophthalmology (1982)
Radiation
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: DMPA and bone density
Authors: Jennifer Hollowell, Peter Littlejohns, Yoav Ben-Shlomo
Journal: BMJ (1991)

for them to monitor whether any effective change had occurred.Only 17% of these schemes used information from routine data collection systems, supporting the comment by Ms Mugford and colleagues that the link between routine systems and clinical research and audit is tenuous.This survey was carried out at a time when interest in medical audit had just been awakened, and 37% of schemes were less than one year old; the situation may now be improved.Evidence from countries such as Canada,5 where audit has been practised for far longer, suggests that problems with completing the audit loop are not unique.Though it is not clear how to alter clinical behaviour most effectively, it is essential that at least the basic principles of audit, such as documenting and monitoring progress, are established if the current input of resources is to be used to any effect.
Index Medicus. A century of medical citation
Authors: J. Kunz
Journal: JAMA (1979)

IN ITS initial year of publication,<i>Index Medicus</i>, which purported to catalog "all current medical journals and transactions of value," listed some 20,000 medical articles from around the world. One hundred years later, it is expected to list more than 250,000 articles—mute testimony to the impressive growth in medical science during the past century, growth that<i>Index Medicus</i>has helped to stimulate as well as to chronicle. When its principal founder, John Shaw Billings, MD, died in 1913, William H. Welch of Johns Hopkins included<i>Index Medicus</i>with Billings' other bibliographic achievements as America's "greatest contribution to medicine."1 Today, judging from the prestige of the National Library of Medicine (NLM) and its best known publication, the<i>Index Medicus</i>has maintained its premiere position. Despite its parallel growth with American medical discoveries and continued international acclaim, the future of<i>Index Medicus</i>has not always been bright. More than once it has
Psychological problems associated with diagnosis and treatment of lymphomas. I: Retrospective study.
Authors: J Devlen, P Maguire, P Phillips, D Crowther, H Chambers
Journal: BMJ (1987)

Patients treated for Hodgkin9s disease and non-Hodgkin9s lymphoma have a better prognosis than other patients with cancer so may have a lower prevalence of psychological and social morbidity. Trained interviewers used standardised methods to assess 90 patients at a mean of 32 months after the diagnosis of Hodgkin9s disease or non-Hodgkin9s lymphoma. Chemotherapy and radiotherapy had commonly caused adverse effects including hair loss, vomiting, nausea, and loss of appetite. Although most patients were free of disease and not receiving treatment at follow up, some still suffered from a lack of energy (31 patients), loss of libido (19), irritability (22), and tiredness (19); 30 patients complained of continued impairment of thinking or disturbance of short term memory. After diagnosis 21 patients had suffered from an anxiety state or depressive illness, or both, while 27 had experienced borderline anxiety or depression, or both. Mood disturbance was positively correlated with adverse effects of treatment, particularly those affecting the gastrointestinal tract. Social adjustment was less affected, but failure to return to work, or a long delay in returning to work, and a persistent lack of interest in leisure activities gave cause for concern. These findings of substantial psychiatric and social morbidity in patients with Hodgkin9s disease and non-Hodgkin9s lymphoma prompted a prospective study of these patients to determine their nature and duration.
Ethical principles in critical care
Authors: J. M. Luce
Journal: JAMA (1990)

THE MOST compelling principle of medical ethics always has been<i>beneficence</i>: acting to benefit patients by sustaining life, treating illness, and relieving pain. A correlative principle is<i>nonmaleficence</i>: refraining from harm. A third principle that has increasingly gained acceptance in the United States is<i>autonomy</i>: respecting the right of patients to determine much of their medical care. Closely related to this is<i>disclosure</i>: providing adequate and truthful information for competent patients to make medical decisions.<sup>1-3</sup>A fifth ethical principle is<i>social justice</i>: allocating medical resources fairly and according to medical need.<sup>4</sup> The first four ethical principles outlined above are the foundation of the fiduciary relationship in which physicians are expected to serve the best interests of their patients as the patients define these interests. This relationship is relatively easy to maintain when primary physicians follow up patients in their offices or in hospital rooms. However, the relationship may
'The wheel within a wheel': meningococcal trends
Authors: G. W. Counts
Journal: JAMA (1980)

The meningococcus has occupied a special position among bacteria causing disease in humans. Epidemiologic data in this country, available since 1920 and reported by the Center for Disease Control (CDC), show that three major epidemics have occurred, with peaks in 1929, 1936, and 1943. At those times the case rate per 100,000 population was 8.6, 5.7, and 13.6, respectively.<sup>1</sup>The most recent sizable epidemic occurred in the early 1950s, with a peak incidence of 3.2 cases per 100,000 population in 1953. In the ten-year period beginning in 1968, disease rates compiled by the CDC have ranged from a low of 0.64 per 100,000 population (1,323 cases in 1972) to 1.46 cases per 100,000 (2,951 cases in 1969). Both the reported total number of cases and rate have increased slightly since 1974.<sup>2</sup> Like the revolving of an outer wheel, epidemics of meningococcal disease have come in waves or cycles.
Hemolytic anemia with positive Coombs' test. Association with isoniazid therapy
Authors: M. G. Robinson
Journal: JAMA (1969)

To our knowledge, only two cases of hemolytic anemia have been associated with the administration of isoniazid, one of these having a positive Coombs' test. We are reporting the second case of Coombs' positive hemolytic anemia due to isoniazid. After a year of isoniazid therapy, a Negro child suddenly began to have severe anemia, abdominal pain, fever, and hemoglobinuria. A direct Coombs' test with standard gamma Coombs' serum was positive on admission. After isoniazid therapy was stopped, the Coombs' test was negative. While the direct Coombs' test was negative, in vitro tests demonstrated the sensitization of the patient to isoniazid.
Neonatal Surgery
Authors: John G. Raffensperger
Journal: JAMA (1969)

The authors of this fine text have recorded their experiences with more than 3,500 newborn infants with surgical lesions whom they have treated at the Liverpool Neonatal Surgical Center. In their opening chapters, they describe the organization of the center which, during the first six years of its existence, reduced the mortality for neonatal surgery in the Liverpool area from 79% to 24%. The tremendous advantages of centralizing the care for malformed infants is immediately obvious. The authors then review in detail the metabolic responses of the neonate, therapy with intravenously administered fluids, infections, anesthesia, and complications of surgery. Dr. Rickham thoughtfully included a discussion of the ethics of surgery in newborn infants which should help physicians who must counsel parents as well as struggle with the babies' problems. The remaining chapters, clearly written monographs on the various congenital lesions, are organized by anatomic divisions. There are delightful historical notes,
Trabecular Meshwork in Primates
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence of cerebral embolism in patients with atrial fibrilation and atrial thrombi and/or spontaneous echo contrast: A prospective and serial study Herald Schmidt, Heyder Omran, Torsten Sommer, Michael Steffens, Stefan Illien, Monika Boes, Hans Schild, Berndt L�deritz. University of Bonn, Bonn, Germany
Journal: Journal of the American College of Cardiology (2001)
Erratum
Journal: Journal of Clinical Oncology (2018)

was published without important information.The raw numbers for local recurrence, nodal metastasis, and disease specific death stratified by Brigham and Women's (BWH) stage have now been included in the new Supplemental Table 1.A sentence has been added to the Results section as the second sentence after the "Validation of the BWH T Staging System" subheading that reads, "The distribution of CSCC poor outcomes by BWH T stage are available in Supplemental Table 1."This has been corrected as of September 26, 2018.