tbuckley/cabot-search huggingface dataset:
Genetic mouse models of essential tremor: are they essential?
Authors: J. Jankovic
Journal: Journal of Clinical Investigation (2005)

The causative genes for essential tremor (ET), one of the most common genetic neurological disorders, have eluded scientists despite intensive search. Two gene loci linked to ET, one on chromosome 3q13 and another on chromosome 2p24.1, have been identified, and a missense mutation in the HS1-BP3 gene on the 2p has been suggested as the cause of the disorder in about 10% of American ET patients. Therefore, the genetic basis for the vast majority of familial ET is still unknown. In this issue of the JCI, the gene coding for the γ-aminobutyric acidA (GABAA) receptor α1 subunit is suggested as a potential candidate gene for ET, as mice lacking the gene express a phenotype that overlaps with some clinical characteristics of the human condition.
TITLES OF PAPERS.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response to Comment on Anjana et al. Incidence of Diabetes and Prediabetes and Predictors of Progression Among Asian Indians: 10-Year Follow-up of the Chennai Urban Rural Epidemiology Study (CURES). Diabetes Care 2015;38:1441–1448
Authors: Ranjit Mohan Anjana, Mohan Deepa, Viswanathan Mohan
Journal: Diabetes Care (2015)
Pediatric Cardiology
Authors: Saul J. Robinson
Journal: JAMA (1964)

Every once in a while a book appears which represents the summation of many other attempts at presenting the subject. This second edition is such a volume. Writing in a remarkably clear and pleasant first person style, the author utilizes the authority of his own experiences and those of many colleagues whom he quotes. He is quite frank in expressing any limitations in his knowledge of a subject. To some of the controversial problems still not clarified there is an almost philosophical approach. The excellent format of the book leads to easy reading. Part I, "The Tools of Diagnosis," covers the procedures which clinicians would use in approaching the diagnosis of any child with cardiac disease. Most important, the limitation of each diagnostic procedure is well presented. Part II discusses acquired heart disease, and Part III, the all important subject of congenital heart disease, with a remarkably good introduction on
Meet the First Authors
Authors: Hossein Ardehali, Åsa Gustafsson, William Goodyer
Journal: Circulation Research (2019)

Cardiovascular Institute, focusing on the discovery of novel regulators underlying the development of the cardiac conduction system (CCS).To overcome the inherent hurdles of studying the CCS (small cell numbers, cell type heterogeneity, etc), he developed a comprehensive transcriptional profile of the entire CCS at single-cell resolution, providing a gene atlas for facilitating future efforts in conduction cell identification, isolation, and characterization in the context of development and disease.
To the Editor of the Journal of the American Medical Association:
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Numeral
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"SUNDOWN DOCTORS AND EVENING COLLEGES."
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TYPE B INFLUENZA INFECTION
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV seroprevalence in injection drug users
Authors: J. K. Watters
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Human immunodeficiency virus (HIV) prevalence among injection drug users (IDUs) is thought to be low in cities in the western United States when compared with New York, NY, Miami, Fla, and Chicago, Ill. Data from published serological surveys of IDUs in San Francisco, Calif, suggest seroprevalence of 8% among IDUs enrolled in drug treatment programs during 1988 through 1990<sup>1</sup>and a mean seroprevalence of 12% (range, 10% to 14%) among heterosexual, street-recruited IDUs during 1987 through 1992.<sup>2</sup>These studies also suggest declining incidence of HIV among San Francisco IDUs in the late 1980s. However, this epidemiologic portrait of center-city populations may not accurately portray conditions in neighboring communities. The Urban Health Study conducts studies of street-recruited IDUs in Northern California. We found higher HIV seroprevalence rates at baseline in smaller, predominantly African-American neighborhoods outside San Francisco than among IDUs within the city (Table). Odds for
Exhaled Nitric Oxide and Asthma
Journal: New England Journal of Medicine (2006)

These three books, each with a distinct content and focus, remind us all of the huge investment the United States has made (and will continue to make) to prevent a biologic attack by terrorists on our citizens.Taken together, they provide a powerful portrayal of where we've been and where we are likely to go in the relatively near future.Today, many in government who have access to classified information are convinced that a biologic attack is not a matter of if, but a matter of when.This prophecy will surely drive a search for answers for years to come.
Mitogenic effect of transforming growth factor-β1 on human Ito cells in culture: Evidence for mediation by endogenous platelet-derived growth factor
Authors: K Win
Journal: Hepatology (1993)

We assessed the effect of transforming growth factor-β1 on the proliferation of human Ito cells. Ito cells in their myofibroblastlike phenotype were grown from explants of human liver and were characterized with electron microscopy and positive immunostaining for desmin and smooth muscle α-actin. Transforming growth factor-β1 was mitogenic for human Ito cells whatever the culture conditions, although it was, as previously described, inhibitory of growth for rat Ito cells. The mitogenic effect of transforming growth factor-β1 was likely due to induction of autocrine platelet-derived growth factor chain secretion by Ito cells themselves because (a) the mitogenic effect of transforming growth factor-β1 was blocked by specific platelet-derived growth factor antibodies, (b) transforming growth factor-β1 increased platelet-derived growth factor-A chain messenger RNA expression and platelet-derived growth factor-AA secretion by human Ito cells and (c) human Ito cells expressed the α-type platelet-derived growth factor-A receptor messenger RNA. Exogenous platelet-derived growth factor-AA was also mitogenic for human Ito cells, mimicking the effect of transforming growth factor-β1. Our data suggest that results obtained with rat Ito cells must be extrapolated with caution to human ones. The mitogenic effect of transforming growth factor-β1 on human Ito cells probably has pathophysiological relevance because transforming growth factor-β1 has been demonstrated in vivo at sites of active liver fibrogenesis. (HEPATOLOGY 1993;18:137–145).
Epidemiology of primary brain tumors: Current concepts and review of the literature
Authors: Margaret Wrensch, Yuriko Minn, Terri Chew, Melissa Bondy, Mitchel S. Berger
Journal: Neuro-Oncology (2002)

The purpose of this review is to provide a suf ciently detailed perspective on epidemiologic studies of primary brain tumors to encourage multidisciplinary etiologic and prognostic studies among surgeons, neuro-oncologists, epidemiologists, and molecular scientists.Molecular tumor markers that predict survival and treatment response are being identi ed with hope of even greater gains in this area from emerging array technologies.Regarding risk factors, studies of inherited susceptibility and constitutive polymorphisms in genes pertinent to carcinogenesis (for example, DNA repair and detoxi cation genes and mutagen sensitivity) have revealed provocative ndings.Inverse associations of the history of allergies with glioma risk observed in 3 large studies and reports of inverse associations of glioma with common infections
AUTHORS' REPLY
Authors: I H Feather, J A Warner, S T Holgate, P J Thompson, G A Stewart
Journal: Thorax (1993)

Cohabiting with domestic mitesDr IH Feather and colleagues have reviewed the central role of house dust mites in the aetiology of allergic asthma (January 1993;43:5-9).In my personal series of 744 consecutive asthmatic children aged 5-15 years compiled over the years 1985-91, positive skin prick test reactions to Dermatophagoides pteronyssinus (ALK, Copenhagen) were nevertheless found in only 180 subjects (24%) and more often among those from rural domiciles, large families, cramped dwellings, and blue collar social classes (table ).The mite population in homes is depen- dent on the supply of food-that is, human skin scales-and air humidity.Since there is generally no shortage of the former it is the humidity that is the decisive factor for mite survival.In many regions the circumstances are ideal for mite growth, and bedrooms in particular are universally infested with mites.In Scandinavia, however, the relative humidity indoors is low during the long cold season from September to May when the houses are heated continuously, and conditions are therefore unsuitable for mites.Modern energy saving with heat insulation and poor ventilation have caused a change in the traditional indoor climate and a rapid rise in mite concentrations and hypersensitivity to mites has resulted in Stockholm,l2 but in northern Scandinavia (for example, Finland) hypersensitivity to mites still remains more or less a social problem.Crowded living conditions pro- vide a food supply for mites and an addi- tional water vapour load which together provide conditions suitable for mite sur- vival.In view of the limited efficiency of acaricides and vacuum cleaning, I agree with the opinion that the mite problem can- not be solved without a change of housing conditions in general.
Vanishing bile duct syndrome: A possible mechanism for intrahepatic cholestasis in Hodgkin's lymphoma
Authors: S Hubscher
Journal: Hepatology (1993)

A syndrome of idiopathic intrahepatic cholestasis occurs in some patients with Hodgkin's lymphoma. The underlying mechanism is poorly understood. In this paper we describe three patients with Hodgkin's lymphoma in whom severe intrahepatic cholestasis of unknown pathogenesis developed. In two cases jaundice was the presenting symptom; all three patients died with intractable liver damage. The three patients were initially thought to have idiopathic Hodgkin's-associated cholestasis, but subsequent review of histological material revealed advanced vanishing bile duct syndrome in addition to severe cholestasis. Ten liver specimens were obtained from 4 to 97 wk after the onset of jaundice (seven needle biopsies, one wedge biopsy, two postmortem livers). In seven liver specimens taken within 30 wk of the onset of jaundice, portal tracts characteristically had a "hurned-out" appearance without secondary periportal changes related to chronic cholestasis. Three biopsy specimens obtained from one of the patients more than 1 yr after the onset of jaundice showed evidence of progressive periportal damage in the form of fibrous expansion, marginal ductular proliferation and copper-associated protein deposition. More than 80% of small portal tracts lacked recognizable bile ducts in the final liver specimens obtained from the three patients. These observations suggest that Hodgkin's lymphoma should be included in the list of diseases associated with loss of intrahepatic bile ducts. The possibility of a vanishing bile duct syndrome should be considered in the differential diagnosis of unexplained intrahepatic cholestasis in patients with Hodgkin's disease. (HEPATOLOGY 1993;17:70–77.)
Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite
Authors: Rebecca A. O'Donnell, Fiona Hackett, Steven A. Howell, Moritz Treeck, Nicole Struck, Zita Krnajski, Chrislaine Withers-Martinez, Tim W. Gilberger, Michael J. Blackman
Journal: The Journal of Experimental Medicine (2006)
Local drug delivery of intramural ethyl alcohol for treatment of diffuse in-stent restenosis: The Beaumont Alcohol Restenosis Study (BARS) John A. Fry, Michael J. Curran, Theodore L. Schreiber, Cindy L. Grines, Steven L. Almany, Terry R. Bowers, Robert D. Safian, Harold Z. Friedman, William W. O'Neill. William Beaumont Hospital, Royal Oak, MI
Journal: Journal of the American College of Cardiology (2001)
Reply
Authors: J. Ph. Lacour
Journal: British Journal of Dermatology (1995)

Journal Article Reply Get access J. Ph. Lacour J. Ph. Lacour Department of Dermatology, Hopital Pasteur, 30, avenue de la vote romaine, BP69‐06002 Nice, Cedex 1, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 2, 1 August 1995, Pages 341–342, https://doi.org/10.1111/j.1365-2133.1995.tb02654.x Published: 01 August 1995
Modification of the Carcinogenic Process in Colorectal Cancer by Endogenous and Exogenous Factors: Effect of Colestipol Hydrochloride on Tumors Induced by Dimethylhydrazine
Authors: J. Patrick Daugherty
Journal: Environmental Health Perspectives (1983)

The effect of the bile acid sequestrant, colestipol hydrochloride, on the incidence of dimethylhydrazine-induced tumors of the large intestine was determined in male Swiss mice. The subcutaneous administration of dimethylhydrazine (15 mg/kg) produced tumors in approximately 89% of the animals with an average of 1.70 tumors per tumor-bearing animal. When carcinogen-treated animals received dietary colestipol (0.52%, w/w) from 4 weeks prior to the first injection of dimethylhydrazine until the time of death, there was an increase in the number of tumors per tumor-bearing animal to 2.23. In an attempt to understand the nature of this enhancement, animals were administered dietary colestipol at different times in relation to the administration of the carcinogen. The number of tumors per tumor-bearing animal for the different protocols was: post-initiation colestipol exposure, 1.70; colestipol exposure concomitant with dimethylhydrazine, 1.41; pre-initiation colestipol exposure, 2.23. Thus, colestipol appeared to function both as an anticarcinogen and as a promoter (pre-initiation). Since colestipol has the capacity to bind a number of chemical agents, the different biological effects probably reflect the multifactorial nature of colorectal cancer with the end result dependent on the balance between opposing factors. The selective administration of colestipol in relation to carcinogen administration may prove useful in elucidating the various factors involved in the etiology of this disease.
Addendum for Euro Surveill. 2018;23(5)
Journal: Eurosurveillance (2018)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Addendum This article is an addendum to the following content: Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018
Data from Short-Term Tests on Motor Vehicle Exhausts
Authors: Ulf Rannug
Journal: Environmental Health Perspectives (1983)

The mutagenicity of motor vehicle exhausts has been studied by using Salmonella typhimurium strains TA 98 and TA 100. Acetone extracts of the particulate phase and the gas phase have been tested in the presence and absence of a metabolizing system (S9). The particulate phases from medium- and heavy-duty diesel vehicles were tested. The vehicles were driven according to a modified 13 mode test, and the particulate phase was sampled at mode 6 (maximum load and intermediate engine speed) and mode 12 (10% load and rated speed). In mode 6 all vehicles gave approximately the same mutagenicity in strain TA 98 (50,000–90,000 revertants/kW-hr) as well as in TA 100 (200,000–360,000 revertants/kW-hr). A higher mutagenic effect, in some cases up to 10 times, was seen with mode 12. Light-duty vehicles of different year models were tested using different fuel/engine combinations. The vehicles were driven according to FTP 72 or ECE driving cycle. Cold starts at two different temperature levels, approx. 0 °C and 23 °C, respectively, were also compared. Based on the mutagenicity of the particulate extracts (given as revertants per km), the light-duty vehicles could be divided into three main groups. The first group, the high mutagenicity group, giving 100,000–700,000 revertants/km, consists only of diesel cars. In the medium mutagenicity group, giving between 20,000 and 100,000 revertants/km, different gasoline fuels are placed, i.e., leaded and lead-free gasoline as well as alcohol/gasoline fuels. Two other fuels, methanol (M95) and propane (LPG), constitute the low mutagenicity group, giving less than 20,000 revertants/km. Fuels from the medium effect group will produce a particulate phase with low mutagenicity if the vehicle is equipped with a three way catalyst with closed loop, or fuel injection. The cold start temperature did not change this classification, since all samples gave a somewhat higher mutagenic effect at the low temperature. With the ECE driving cycle, much lower mutagenicity was noted with the diesel cars than in the tests with the FTP-72 driving cycle, at least with tester strain TA 98. On strain TA 100 the diesel exhaust samples still showed a much higher mutagenicity than other samples. Acetone extracts of the gas phase from diesel and gasoline exhaust (trapped in ice/water condensers and CO2/ethanol condensers) also gave mutagenic effects. The contribution of the gas phase to the mutagenic effects seems to be more important in the absence of S9 and more important in the case of gasoline exhausts.