tbuckley/cabot-search huggingface dataset:
Abstract 1411: Semi-quantitative mapping of oncological therapies with mass spectrometry imaging
Authors: Dodge Baluya, Bindesh Shrestha, Erik N. Cressman
Journal: Cancer Research (2019)

Abstract Hepatocellular carcinoma (HCC) is one of the challenging cancers to treat with occurrence steadily rising in the United States. While surgical resection is considered curative, it is not available to patients who have underlying liver problems, such as chronic liver disease. Liver transplantation may be considered in these cases but recurrence is a possibility, and transplantation occurs for &amp;lt;5% of all HCC cases. Doxorubicin (DXR), a drug derived from a natural product extracted from several wild strains of Streptomyces, is used to treat different types of cancer, particularly liver cancer such as HCC. While DXR use for treatment shows positive efficacy, the side effects such as cardiomyopathy and typhlitis, are easily triggered when the systemic concentration dose reaches a particular threshold. Also, there is no confirmation that the drug reaches the target area with a viable therapeutic concentration. In this work, we use mass spectrometry imaging (MSI) platform on Waters SYNAPT G2-Si MALDI to gather spatial information and quantity of the DXR to determine the delivery efficacy. To generate a calibration curve that is suitable for MSI, a phantom tissue template was created. Livers were extracted from pig and homogenized using a Qiagen Tissuelyzer with a 30% w/v in deionized water, and created DXR tissue homogenate solutions (20, 10, 5, 2, 1µM) using serial dilution. The resulting solutions were pipetted into a gelatin mold before it was frozen using liquid nitrogen and stored at -80 °C until needed. For the ‘unknown’ samples, the liver was explanted from a pig that was treated with doxorubicin, then flash-frozen using liquid nitrogen and kept at -80 °C until needed. The tissue was sectioned using a Leica cryotome and mounted on glass microscope slides. For each analysis, two adjacent sections were selected, one was submitted for MSI analysis and the other for IHC staining. A good correlation (R&amp;gt;0.99) of the DXR signal from the tissue homogenates showed that the calibration curve could be used to comparably measure the DXR amount in the similar tissue type. MSI of the explanted liver showed the distribution of DXR towards a particular section. While this experiment showed only the response for DXR, this approach can be applied to other drug therapies to show the localization and concentration, thereby helping the effectivity assessment of the therapy complementary with the other evaluation tools for a successful treatment. Citation Format: Dodge Baluya, Bindesh Shrestha, Erik N. Cressman. Semi-quantitative mapping of oncological therapies with mass spectrometry imaging [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1411.
Marfan's syndrome with complete heart block and junctional rhythm
Authors: E. S. Bear
Journal: JAMA (1971)

Asymptomatic complete heart block with a junctional rhythm was discovered in a 26-year-old black man with Marfan's syndrome. The arrhythmia was documented by electrocardiograms and His bundle electrocardiography. The patient also exhibited an abnormally small right coronary artery, low serum levels of cholesterol, phospholipids, and total lipids.
Gemcitabine/cisplatin in patients with advanced bladder and impaired renal function: A retrospective analysis.
Authors: J. Carles, E. Muñoz, J. Bellmunt, B. Mellado, M. Guix, M. Gallen, A. Font, R. Morales, C. Suarez, C. Valverde
Journal: Journal of Clinical Oncology (2010)

e15002 Background: A four-weekly regimen of gemcitabine and cisplatin (GEMCIS) has similar activity and is less toxic than MVAC in advanced bladder cancer. However, full dose cisplatin in unfit patients with impaired renal function is contraindicated and other carboplatin based schedules have been developed. We have previously reported the feasibility of GEMCIS in a biweekly schedule in unfit patients with renal impairment. Here we report a multicenter retrospective study of this biweekly regimen in patients with impaired renal function. Methods: Between January 2004 and October 2009, 40 patients with locally advanced non-surgically resectable or metastatic bladder cancer and impaired renal function were included. Treatment consisted of gemcitabine 2500 mg/m2 on day 1 and cisplatin 35 mg/m2 on day 1, every 14 days. Results: Median age of the patients was 73 years (range: 51-82 years). Median IK was 80% (range: 60-100%). Mean creatinine clearance was 49 ml/min (range:37-59 ml/min). Eight patients had previously received chemotherapy with gemcitabine and/or platinum based therapy. Metastatic localizations were: 17 lymph nodes, 10 pulmonary, 10 bone, 7 liver, 12 pelvic and 1 central nervous system. The median number of cycles/patient was 6 (1-13). Out of 36 patients evaluable for response, there was one complete response, 14 partial responses (ORR: 42%; 95% CI 27-58%), 11 stabilizations and 10 progressive diseases. Haematological toxicities were: grade I anaemia in 15 patient, grade II in 8; grade III in 2; grade III neutropenia in 5 patients and grade IV in 1 patient; grade III plaquetopenia in 3 patients. Non-hematological toxicities were: grade I-II vomiting in 2 patients. Two patients showed a grade II hepatic toxicity. Worsening of the renal function was observed in two patients. Alopecia grade I-II was seen in three patients. There was one toxic death related to metabolic acidosis.The median progression free survival is 15 weeks. The median OS from first cycle of GEMCIS was 35 weeks and 1 year OS was 43% (St error 9%). Conclusions: A two-weekly schedule of gemcitabine plus cisplatin is feasible, active and generally well tolerated in an outpatient setting in unfit patients with poor renal reserve. No significant financial relationships to disclose.
ANTITYPHOID SERUM.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lehrbuch der Gynäkologie für Studierende und Aerzte.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Untitled
Authors: Otto Thomas
Journal: Annals of Internal Medicine (2008)

Ad Libitum2 December 2008UntitledOtto Thomas, MDOtto Thomas, MDFrom the University of Rochester Medical Center, Rochester, NY 14642.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-11-200812020-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail And ... Author, Article, and Disclosure InformationAffiliations: From the University of Rochester Medical Center, Rochester, NY 14642.Current Author Address: Otto Thomas, MD, University of Rochester Medical Center, 601 Elmwood Avenue, Box 99, Rochester, NY 14642. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 December 2008Volume 149, Issue 11Page: 803KeywordsBoneBrainThyroidThyroid carcinoma ePublished: 2 December 2008 Issue Published: 2 December 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Photic Sneezing
Authors: Henry C. Everett
Journal: JAMA (1965)

<h3>To the Editor:—</h3> I, too, am a photic sneezer. On reading Dr. Pratt's experience, I decided to attempt to evoke a sneeze by squinting forcefully in the absence of bright light. The result was negative. However, in the course of studying people with the reflex, I found a woman who sneezed when she rubbed the inner corners of her eyes, a phenomenon which might lend support to the tear-forcing thesis. Since the study was published (<i>Neurology</i><b>14</b>:483 [May] 1964), I have received some interesting correspondence about various stimuli for sneezing, including a letter from a doctor who noted that some of his patients sneezed when their hair was combed.
Investigation of potential salivary biomarkers for the early diagnosis of breast cancer.
Authors: Takeshi Murata, Maiko Takahashi, Tetsu Hayashida, Masahiro Sugimoto, Hiromitsu Jinno, Makoto Sunamura, Yuko Kitagawa
Journal: Journal of Clinical Oncology (2014)

e22228 Background: Saliva is an easily accessible and informative biological fluid which has high potential for the early diagnosis of diseases. Saliva-based diagnostics, particularly those based on metabolomics technology, offer a promising clinical strategy by characterizing the association between salivary analytes and a particular disease. The aim of this study is to investigate potential biomarkers in human saliva to facilitate the early diagnosis of breast cancer. Methods: We conducted a comprehensive metabolite analysis of saliva samples obtained from 60 stage 0-II breast cancer patients (49 invasive ductal carcinoma (IDC), 9 ductal carcinoma in situ and 2 other type) and 20 healthy controls, using capillary electrophoresis time-of-flight-mass spectrometry (CE-TOF-MS). Thirty-two patients received neoadjuvant treastment (14 chemotherapy and 18 endocrine therapy). Statistical analyses were performed by using a nonparametric Mann-Whitney U-test, multiple logistic regression and the receiver operating characteristics (ROC) to evaluate the predictive power of biomarkers. Results: After removing the concomitantly observed peaks and noise peaks, totally 205 peaks derived from the metabolites were observed. Among these peaks, five potential salivary biomarkers demonstrated significantly higher concentrations in breast cancer patients comparing with healthy individuals (p < 0.05). Especially, salivary biomarkers obtained from patients with IDC before neoadjuvant treatments tended to be higher concentrations than those obtained after treatment. Of these, five metabolites showed high the area under the ROC curves (AUCs) values; 0.850, 0.819, 0.809, 0.765, and 0.716. Conclusions: Salivary metabolites are promising biomarkers for the early diagnosis of breast cancer.
Lyme disease: spirochetes up to old ticks?
Authors: P. Gunby
Journal: JAMA (1982)

A medical mystery, first brought to researchers' attention by two Connecticut mothers, may be nearing solution. It involves an inflammatory disorder that has come to be known as Lyme disease. Investigation began more than six years ago (<i>JAMA</i>[MEDICAL NEWS] 1976;236:241-242), and now researchers from the Rocky Mountain Laboratories, Hamilton, Mont, are reporting a possible cause—a spirochete isolated from ticks of the<i>Ixodes</i>genus. Lyme, the town from which the disease draws its name, is a small community about 15 km north of Long Island Sound near the Connecticut River. In late 1975, a woman from that community, whose daughter was diagnosed as having juvenile rheumatoid arthritis, telephoned Connecticut's state health department in Hartford to point out that at least 11 other children in the locality had similar symptoms. Could there be an explanation other than arthritis? The department shared this information with researchers at Yale University School of Medicine
Fibromyomatous Erythrocytosis
Authors: Elie D. Aboulafia, Harold F. Rheinlander, Robert S. Schwartz
Journal: New England Journal of Medicine (1962)

The association of erythrocytosis (secondary polycythemia) and uterine fibroids was first described by Thomson and Marson1 in 1953. Since then, 8 additional cases have been reported.2 3 4 5 6 7 8 The characteristic features of this syndrome are erythrocytosis in association with a myomatous uterus and restoration of normal hematologic values after hysterectomy.In all the cases reported, except that of Zilliacus,8 the red-cell counts were over 6,100,000, and the hemoglobin values were over 18.0 gm. per 100 ml. The highest values recorded were those of a red-cell count of 8,500,000, a hemoglobin of 20.4 gm. per 100 ml. and a hematocrit of 78 vol. . . .
Perinatal Medicine
Authors: William Oh
Journal: JAMA (1976)

Here is a welcome addition to the growing list of textbooks on neonatology. Unlike most other multi-authored texts, this was written primarily by the two principal authors (19 of 25 chapters), with the additional contributions by specialists in neonatal radiology, surgery, pharmacology, cardiology, genetics, and medical ethics. The chapters on administrative aspects in the organization of a neonatal intensive care unit, psychosocial problems in the care of a normal newborn, signs of neonatal illness, and medicolegal aspects of neonatalogy contain information useful to students and primary care physicians as well as neonatologists. On the other hand, there are deficiencies that could be remedied in future editions. For instance, a contribution by an obstetrician-perinatologist on the diagnosis and management of high-risk pregnancy would have enhanced the breadth and depth of the volume. A dermatologist familiar with the skin disorders in the neonate could also have made a desirable contribution. The bibliography
Molecular and Cellular Mechanisms in Disease.
Journal: Annals of Internal Medicine (1977)

6Book reviewsThere are, therefore, gr questioning some of the reached in the monographs.N in the wake of the Health an Work Act in this country legislation in the United elsewhere, this collection of r is extremely useful in pointin, at carcinogenically hazardous chemicals and in providing su available relevant information rounds for 'Cancer', the author covers a w conclusions of pathology which is presen revertheless, mixture of biochemistry, molec Ld Safety at logy, and tissue pathology.This and similar a vast amount of information, States and often given a short historical pe nonographs but it is difficult to read exc g the finger reference textbook.and suspectInevitably a text of this sca immaries of the lack of depth of the sini .
Benign Osteopetrosis
Authors: L ROSENTHALL
Journal: Clinical Nuclear Medicine (1990)

A case of a 3½-year-old female with benign osteopetrosis is presented. There was radiographic evidence of previous fetal sclerosis of bone yielding a “bone-within-abone” appearance, but on radiophosphate imaging this fetal sclerosis was not hyperactive and could not be differentiated from the normal diaphysis surrounding it.
Atropine poisoning in children during the Persian Gulf crisis. A national survey in Israel
Authors: Y. Amitai
Journal: JAMA (1992)

<h3>Objective.</h3> —To evaluate the effects of high doses of atropine in children accidentally injected with automatic atropine injectors. These were distributed in Israel during the Persian Gulf Crisis as an antidote for chemical warfare agents. <h3>Design and Setting.</h3> —A national survey in pediatric emergency departments in Israel, involving 22 medical centers, with prospective data collection in 14 centers. <h3>Patients.</h3> —Children (n=268) presenting to emergency departments following misuse of automatic atropine injectors. <h3>Main Outcome Measures.</h3> —Documentation of atropine dose and clinical manifestations; determination of a clinical severity score and its correlation with atropine dose; measurements of serum atropine levels in six patients. <h3>Results.</h3> —Over a period of 4 months, 268 cases were reported, of which 240 were clinically evaluated. The most common site of injection (75%) was the finger or palm. Doses were up to 17-fold higher than standard doses for age. In 116 children (48%), systemic effects of atropine were observed, and 20 (8%) had severe atropinization. Seizures and life-threatening arrhythmias were not reported, and there were no fatalities. The severity of atropinization was correlated with the dose following a classic nonlinear, dose-response relationship. Serum atropine levels (6.2 to 61.0 ng/mL) were much higher than those observed after administration of therapeutic doses. <h3>Conclusions.</h3> —The high incidence of injection in the hand implies accidental use of automatic atropine injectors among children. The lack of mortality or life-threatening complications from injection of large doses of atropine attests to its relative safety in children. The low risk from atropine injections weighed against expected benefit as a lifesaving antidote justifies the distribution of personal atropine injectors to children at risk of organophosphorus nerve agent attack. (<i>JAMA</i>. 1992;268:630-632)
Fish Oil
Authors: Jeffrey A. Fisher
Journal: JAMA (1989)

<h3>To the Editor.—</h3> I commend Dr Yetiv<sup>1</sup>for his excellent review of the biochemistry and clinical applications of fish oil. However, despite his recognition that these substances do have a legitimate therapeutic role, Dr Yetiv fails to solve the problem for what he admits is the largest segment of potential fish oil consumers—the healthy individual. Most Americans are aware now that increased consumption of fish may be associated with a reduced risk of cardiovascular disease, yet many do not put this into practice. A US Department of Agriculture survey showed that almost half the population does not like fish; of those that do, the majority eat either nonfatty species or fish prepared in an unhealthful manner (eg, fried). While it is true that there have been no long-term interventional studies of low-dose fish oil supplementation, the epidemiology supporting low-dose supplementation is strong and, by Dr Yetiv's admission, unlikely to
Family practice in hospitals
Authors: B. D. Weiss
Journal: JAMA (1985)

FAMILY practice became medicine's 20th-recognized specialty in 1969, when both the American Medical Association's Council on Medical Education and the Advisory Board for Medical Specialties approved formation of the American Board of Family Practice.<sup>1-3</sup>In 1970 and again in 1976, the AMA's House of Delegates adopted a resolution stating that hospital departments of family practice should be established "with duties and responsibilities comparable to any other specialty department of the [hospital's] medical staff."<sup>4,5</sup>Coincident with the 1976 resolution, the Joint Commission on Accreditation of Hospitals (JCAH) authorized family physicians to exercise clinical privileges according to the rules and regulations of their own departments.<sup>6,7</sup> Despite recognition by these national organizations, family practice departments in hospitals have yet to be fully accepted. In many hospitals, departments of family practice are the only departments that do not have responsibility for recommending their own members for hospital privileges. Family physicians at
MEDICAL LICENSURE
Authors: William R. Tymms
Journal: JAMA (1935)

<h3>To the Editor:—</h3> In table 10 of the extremely valuable statistics of medical licensure presented inThe Journal, April 27, and still more markedly in the map appearing on page 1513, the merit so well deserved by the various state examining boards for their efforts to exclude the more poorly or the unqualified candidates from the practice of medicine seems to be very unfairly assigned to certain states, whose legislatures appear to have done their utmost to make nugatory the endeavors of their own examining boards. Thus for example this state of Maine, where I reside, is indicated on the map unshaded, indicating that it licenses no osteopaths, no undergraduates, and no graduates of unapproved schools: on the other hand the state of Massachusetts, in company with three others, is shown in black, having in 1934 licensed twenty-one osteopaths and fifty-four other undesirable nondescripts, out of a total of 216
THE HEALTH OF WOMEN WAGE EARNERS
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The human visual cortex responds to gene therapy–mediated recovery of retinal function
Authors: Manzar Ashtari, Laura L. Cyckowski, Justin F. Monroe, Kathleen A. Marshall, Daniel C. Chung, Alberto Auricchio, Francesca Simonelli, Bart P. Leroy, Albert M. Maguire, Kenneth S. Shindler, Jean Bennett
Journal: Journal of Clinical Investigation (2011)
The Role of Tumor Necrosis Factor α in Modulating the Quantity of Peripheral Blood-Derived, Cytokine-Driven Human Dendritic Cells and Its Role in Enhancing the Quality of Dendritic Cell Function in Presenting Soluble Antigens to CD4+ T Cells In Vitro
Authors: Bing-guan Chen, Yijun Shi, Jeffrey D. Smith, David Choi, James D. Geiger, James J. Mulé
Journal: Blood (1998)