tbuckley/cabot-search huggingface dataset:
OCEANS: A randomized, double-blinded, placebo-controlled phase III trial of chemotherapy with or without bevacizumab (BEV) in patients with platinum-sensitive recurrent epithelial ovarian (EOC), primary peritoneal (PPC), or fallopian tube cancer (FTC).
Authors: C. Aghajanian, N. J. Finkler, T. Rutherford, D. A. Smith, J. Yi, H. Parmar, L. R. Nycum, M. A. Sovak
Journal: Journal of Clinical Oncology (2011)

LBA5007 Background: BEV, a humanized anti-VEGF monoclonal antibody, has shown a progression-free survival (PFS) benefit in 2 frontline phase III trials in patients with EOC, PPC and FTC. The therapeutic impact of BEV in combination with carboplatin (C) and gemcitabine (G) followed by single agent BEV to disease progression (PD) was evaluated in this phase III trial in the platinum-sensitive recurrent setting. Methods: Patients had recurrent, platinum-sensitive EOC, PPC or FTC, 1 prior regimen, no prior BEV, ECOG performance status 0-1, measurable disease. Subjects were randomized to: Arm A: [IV C (AUC 4, Day (D) 1) + G (1,000 mg/m 2 D1 and 8) + placebo (PL) D1] q21D x 6 cycles (c) → PL q21D until PD or unacceptable toxicity (tox) Arm B: [CG + BEV (15 mg/kg) D1] q21D x 6 c → BEV q21D until PD or tox primary endpoint was investigator assessed PFS (RECIST). Secondary endpoints included objective response (OR), overall survival (OS), duration of response and safety. The design provided 80% power to detect a 27% reduction in the hazard of progression or death in Arm B vs A, limiting the overall type I error of 5%. Results: OCEANS enrolled 484 patients (242 per arm) from 4/07 - 1/10, median follow up of 24 months. BEV plus CG followed by single agent BEV to PD significantly increased PFS compared to CG alone (HR=0.484, p&lt;0.0001). OR increased by 21% (p&lt;0.0001). OS data is immature with only 29% of patients having had an event. The safety profile was consistent with other BEV trials. Conclusions: Results show a statistically significant and clinically relevant benefit when bevacizumab is added to chemotherapy in patients with recurrent, platinum sensitive EOC, PPC, and FTC. This is the first phase III trial of an antiangiogenic to demonstrate a clinical benefit to these patients. [Table: see text]
Preserve NIOSH...
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organisation/Outcome/Scoring
Authors: G. A. Pearson, P. Barry, F. Shann, D. Field, R. C. Tasker, I. James, Reinoud J. B. J. Gemke, Gouke J. Bonsel, A. Johannes van Vught, Jose Irazuzta, Jianliang Zhang, Sukamar Pandit, Forest Arnold, A. Saporiti, M. Althabe, A. Albano, D. Allende, C. Bordin, S. Goldshmidt, J. Mendilaharzu, F. Olazarri, M. Oviedo, J. Peltzer, E. Shnitzler, J. Silbergber, H. Tamush, J. Trentadue, J. Vassallo, M. Wells, J. F. Riera-Fanego, J. Lipman, Abdulsamad A. Abood, I. David Todres, Morris Earle, Michael Jellinek, Frank Shann
Journal: Intensive Care Medicine (1996)
Heredity and Parenthood.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphoma of the eyelid
Authors: M. S. Dresner
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A5.8 Synovial wnt and wisp1 expression induces expression of cartilage-degrading metalloproteinases in the synovium
Authors: M H van den Bosch, A B Blom, S W F Suen, A E van Erp, F A van de Loo, E N Blaney Davidson, P M van der Kraan, P L van Lent, W B van den Berg
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Consequences of synovial activation, seen in many OA patients, are largely unknown. Previously, we found strong upregulation of various members of the Wnt signalling pathway in knee joints of two experimental OA models. Wnt signalling has been implicated in OA incidence via activation of β-catenin. Here we investigated the potential of Wnt signalling to increase the expression of cartilage-degrading enzymes in the synovium. <h3>Methods</h3> Pathway analysis of microarray data from the synovium of a collagenase-induced OA mouse model was done. <i>In vivo</i> synovial overexpression of genes was achieved by intra-articular injection of adenoviral vectors. Joint pathology was assessed by histology. Gene expression was analysed by qPCR. Human OA synovial specimens were collected and either stimulated or used for outgrowth of OA fibroblasts. Human macrophages were differentiated from monocytes, isolated from buffy-coats. <h3>Results</h3> Pathway analysis using DAVID showed enrichment of Wnt signalling in the synovium during experimental OA. To determine the effects of Wnt signalling on synovial tissue, we stimulated human OA synovial specimen with Wnt3a or WISP1, a downstream protein of canonical Wnt signalling, which resulted in increased expression of various MMPs. Contrastingly, the expression of TIMPs, inhibitors of MMPs, was not altered. Blocking Wnt signalling with specific inhibitors decreased the MMP expression. Next, we investigated which cell type in the synovium may cause the increased MMP expression. Stimulation of human synovial OA fibroblasts with Wnt3a or WISP1 increased the expression of MMPs, whereas stimulation of M1 and M2 macrophages did not. However, Wnt signalling strongly upregulated the MMP expression in monocytes, whereas TIMP levels remained unchanged. To determine if synovial overexpression of members of the Wnt signalling pathway leads to cartilage damage <i>in vivo</i>, we injected adenoviral vectors for Wnt8a, Wnt16 and WISP1 into murine knee joints. These vectors, due to their size, specifically target synovial cells and not cartilage. Seven days after overexpression, we found a significant induction of OA pathology. Lesions were found in 92% (n = 12) of the knee joints after Wnt8a overexpression compared to 17% (N = 12) for the control virus and 80% (N = 5) for Wnt16 overexpression, but only 20% (N = 5) for the control virus. <h3>Conclusions</h3> Canonical Wnts produced in the synovium may play an important role in OA pathology by increasing the production of MMPs in the synovium. Overexpression of Wnt signalling members, as is found in experimental OA, induces cartilage damage <i>in vivo</i>. This underlines synovial Wnt and WISP1 expression to be potential targets for OA therapy.
The impact of a drug information sheet on the understanding and attitude of patients about drugs
Authors: M. W. Johnson
Journal: JAMA (1986)

A proposed Food and Drug Administration program to require written information with prescription drugs could cost $500 million annually; the American Medical Association has implemented a similar, voluntary program costing more than $3 million. However, the educational impact of written drug information has not been studied. We evaluated one-page drug information sheets using an objective examination. The baseline score of 71 patients was 3.9 of 6.0. Patients tested before and one day after receiving the drug sheet improved their score by +1.4. In the second phase, patients randomized to receive the drug sheet improved their score after one month by +1.1; those not given the sheet had no improvement. Changes in attitudes and incidence of reported adverse effects seemed to be random and unrelated to the information sheet. Thus, a drug information sheet may be a useful adjunct to patient education. (<i>JAMA</i>1986;256:2722-2724)
Maestro Guillermo
Authors: David W. Hines
Journal: Annals of Internal Medicine (2007)

On Being a Doctor6 November 2007Maestro GuillermoDavid W. Hines, MDDavid W. Hines, MDFrom Rush Medical College, Chicago, IL 60612.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-9-200711060-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It was the Wednesday evening before Thanksgiving, and I was hurrying through my infectious disease rounds to get to the airport to meet my wife's relatives arriving for the holiday. Guillermo had been admitted the week before to 4 North, my last stop, because of some painful Kaposi lesions encircling his legs. Once social service made outpatient arrangements, a quick note would ordinarily suffice for discharge, but he usually had many questions written on a pad of paper. Our agreement was that for every question I answered, he taught me a new word in Spanish. I had decided for expediency's ... Author, Article, and Disclosure InformationAffiliations: From Rush Medical College, Chicago, IL 60612.Corresponding Author: David W. Hines, MD, 629 North Oak Park, Oak Park, IL 60302; e-mail, [email protected]net. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 November 2007Volume 147, Issue 9Page: 670KeywordsChildrenHIVLesionsMedicareOutpatientsPsychiatry and mental healthReuptake inhibitorsSerotoninShouldersSuicide ePublished: 6 November 2007 Issue Published: 6 November 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Analyses of extravascular fluids
Authors: W. H. Shafer
Journal: JAMA (1969)

The examination of fluid collections from the pericardial, pleural, and abdominal cavities and the joints remains a frequent adjunct to other diagnostic techniques.<sup>1</sup>Normally these serous cavities contain only small amounts of fluid for lubrication. A wide variety of pathologic conditions may cause abnormal collections of fluid which are classified according to composition as transudate or exudate. A<i>transudate</i>is formed by an alteration in the normal mechanisms that regulate the exchange of fluid between the vascular and extravascular compartments. This interchange of fluid between the blood and the tissue spaces is controlled by the balance between the capillary blood pressure forcing fluid into the tissue spaces and the osmotic pressure of the plasma proteins which returns fluid into the vascular compartment. The protein molecules diffuse to a limited extent. The small molecules, such as water, electrolytes, and crystalloids, diffuse back and forth rapidly. The concentration of the small
Violence against women. Relevance for medical practitioners. Council on Scientific Affairs, American Medical Association
Authors: Yank D. Coble, A. Bradley Eisenbrey, E. Harvey Estes, Mitchell S. Karlan, William R. Kennedy, Patricia J. Numann, William C. Scott, W. Douglas Skelton, Richard M. Steinhilber, Jack P. Strong, Christine G. Toevs, Henry N. Wagner, Angela Browne
Journal: JAMA (1992)

Evidence collected over the last 20 years indicates that physical and sexual violence against women is an enormous problem. Much of this violence is perpetrated by women's intimate partners or in relationships that would presumably carry some protective aura (eg, father-daughter, boyfriend-girlfriend). This violence carries with it both short- and long-term sequelae for women and affects both their physical and psychological well-being. The high prevalence of violence against women brings them into regular contact with physicians; at least one in five women seen in emergency departments has symptoms relating to abuse. However, physicians frequently treat the injuries only symptomatically or fail to recognize the injuries as abuse. Even when recognized, physicians are often without resources to address the needs of abused women. This report documents the extent of violence against women and suggests path that the physician community might take to address the needs of victims.
Genetic compatibility may explain recurrent spontaneous abortions
Authors: C. Yarbrough
Journal: JAMA (1981)

Aless than 1% chance exists that any randomly selected male and female would share more than one antigen of the major histocompatibility complex. Yet, although rare, this genetic compatibility does occur in couples, and it may explain repeated spontaneous abortions of karyotypically normal fetuses, according to Alan E. Beer, MD, chairman of the Department of Obstetrics and Gynecology at the University of Michigan Medical School, Ann Arbor. Speaking at the American Fertility Society's annual meeting in Atlanta, Beer reported on his and other scientists' research that implicates male-female genetic homozygosity as a cause not only of habitual spontaneous abortions, but perhaps also of other reproductive failures, such as intrauterine growth retardation. (Among other investigators who have carried out such research are J. Glenn Lauritsen and colleagues in Aarhus, Denmark, and Luise Komlos and colleagues in Tel Aviv.) Beer also described the successful results of his laboratory's efforts to override this
The influence of diet on the appearance of new lesions in human coronary arteries
Authors: D. H. Blankenhorn
Journal: JAMA (1990)

The Cholesterol Lowering Atherosclerosis Study, a randomized, placebo-controlled trial of blood lipid lowering, demonstrated significant benefit in 2-year coronary angiograms. Using angiograms of subjects in the Cholesterol Lowering Atherosclerosis Study who received a placebo and 24-hour dietary recall data, we performed an epidemiologic study of risk factors for formation of new atherosclerotic lesions. Age and baseline plus on-trial lipid levels, blood pressure levels, and diet variables were included. Significant dietary energy sources were protein, carbohydrate, alcohol, total fat, and polyunsaturated fat. Each quartile of increased consumption of total fat and polyunsaturated fat was associated with a significant increase in risk of new lesions. Increased intake of lauric, oleic, and linoleic acids significantly increased risk. Subjects in the Cholesterol Lowering Atherosclerosis Study in whom new lesions did not develop increased dietary protein to compensate for reduced intake of fat by substituting low-fat meats and dairy products for high-fat meats and dairy products. These results indicate that when total and saturated fat intakes are reduced to levels recommended by the National Cholesterol Education Program, protein and carbohydrate are preferred substitutes for fat calories, rather than monounsaturated or polyunsaturated fat. (<i>JAMA</i>. 1990;263:1646-1652)
Patient profile of an otolaryngologic emergency department
Authors: M. S. Granick
Journal: JAMA (1983)

An epidemiologic analysis is presented of the utilization patterns of an emergency department (ED) that treats otolaryngologic diseases. Descriptive data are collated and cross-tabulated from 2,504 patient contacts occurring during an eight-month period. Most patients use the facility as their primary physician contact during usual business hours. Most patients complain of an ear problem, and two thirds of the patients have one of 12 common disorders. The cost-effectiveness of an independent specialty ED is evaluated. (<i>JAMA</i>1983;250:933-935)
Patient outcomes after lumbar spinal fusions
Authors: J. A. Turner
Journal: JAMA (1992)

<h3>Objectives.</h3> —To determine success and complication rates for lumbar spinal fusion surgery, predictors of good outcomes, and whether fusion improves success rates of laminectomy for specific low back disorders. <h3>Data Sources.</h3> —English-language journal articles published from 1966 through April 1991, identified through MEDLINE searching (<i>spinalfusion</i>plus limiting terms), bibliography review, and expert consultation. <h3>Study Selection.</h3> —Articles were selected only if they reported at least 1 year of follow-up data enabling the classification of clinical outcomes as satisfactory or unsatisfactory for at least 30 patients. <h3>Data Extraction.</h3> —Two reviewers independently extracted data on patient characteristics, surgical methods, patient outcomes, and quality of study methods. <h3>Data Synthesis.</h3> —Of 47 articles, there were no randomized trials. Four nonrandomized studies compared surgery with and without fusion for herniated disks; three found no advantage for fusion. On average, 68% of patients had a satisfactory outcome after fusion, but the range was wide (16% to 95%), and the satisfactory outcome rate was lower in prospective than in retrospective studies. The most frequently reported complications were pseudarthrosis (14%) and chronic pain at the bone graft donor site (9%). Clinical outcomes did not differ by diagnosis or fusion technique, but were worse in studies with a greater number of previously operated patients. <h3>Conclusions.</h3> —For several low back disorders no advantage has been demonstrated for fusion over surgery without fusion, and complications of fusions are common. Randomized controlled trials are needed to compare fusion, surgery without fusion, and nonsurgical treatments in rigorously defined patient groups. (<i>JAMA</i>. 1992;268:907-911)
Mark Twain on evidence based practice
Journal: BMJ (2003)

large cities in industrialised nations. 5This might be because tuberculosis may be suspected and investigated more readily among men or black or Asian people.Our study was limited by the amount of missing surveillance data.It was also impossible to determine the relative contribution of patient and healthcare provider to the total delay.Potential confounders-for example, coinfection with HIV or the accuracy of the data among patients whose first language was not English-were not taken account of.Recent campaigns have tried to raise awareness of tuberculosis, particularly among ethnic minority groups.Our data suggest that campaigns also need to be targeted at white people, who comprise a third of cases.We thank John Watson for access to the anonymised data from the national tuberculosis survey 1998.
Council on Drugs. List no. 79. New names
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serratia septicemia.
Authors: R A Hughes, P K Hopper
Journal: BMJ (1970)

hernias repaired.On examination the lump was found to be closely associated with and deep to the umbilicus, of a cystic consistency, but did not give a cough impulse nor was it reducible- into the peritoneal cavity.At operation, the swelling was found to com- municate with the peritoneal cavity.It contained an appendix, the tip of which was chronically inflamed and adherent to the under surface of the umbilical skin.Routine appendicectomy was carried out and no other abnormality was noted.f--.4.. Photograph of specimen with umbilicus and attached appendix.The specimen (Fig. ) was sectioned and microscopic appearances were that of a mild interstitial inflammation of the appendix.Postoperatively he did well and was dis- charged home two weeks after his operation.At follow-up one month later he was well.