tbuckley/cabot-search huggingface dataset:
Polycystic Liver Disease with Portal Hypertension
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Years of Healthy Life--Selected States, United States, 1993-1995
Journal: JAMA (1998)

Some public health policy goals in the United States have been expressed as increases in the number of years of healthy life (YHL) (i.e., quality-adjusted life years), a measure of health that combines the effects of mortality with information about morbidity and disability. Data from national health surveys, in combination with life-table death rates and other information, have been used to calculate national estimates of the expected number of YHL at a given age. This report summarizes an analysis of data from the Behavioral Risk Factor Surveillance System (BRFSS) using these methods to estimate YHL for state populations during 1993-1995. The findings indicate substantial variability among the participating states.
Essentials of Diseases of the Skin Including Syphilis. Arranged in the Form of Questions and Answers. Prepared Especially for Students of Medicine.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Breast cancer in a male-to-female transsexual. A case report
Authors: T. J. Pritchard
Journal: JAMA (1988)

The clinicopathological findings in a patient who developed breast carcinoma ten years after male-to-female sexual reassignment are reported. Only two other cases of transsexual men with breast carcinoma have been reported previously. All three patients received oral estrogens for prolonged periods to maintain secondary female characteristics. The controversies relating to hormonal influences in the etiology of breast cancer in men are discussed herein. (<i>JAMA</i>1988;259:-2278-2280)
Standards of Medical Care for Patients With Diabetes Mellitus
Journal: Diabetes Care (1993)

Standards of Medical Care for Patients With Diabetes MellitusD iabetes is a chronic illness that requires continuing medical care and education to prevent acute complications and to reduce the risk of long-term complications.People with diabetes should receive their treatment and care from physicians with expertise and a special interest in diabetes.The following standards define basic (minimum) medical care for people with diabetes.These standards are not intended to preclude more extensive evaluation and management of the patient.For more detailed information refer to Physician's Guide to Insulin-Dependent (Type I) Diabetes: Diagnosis and Treatment and Physician's Guide to Non-Insulin-Dependent (Type 11) Diabetes: Diagnosis and Treatment.
Oxidative Stress–induced Antibodies to Carbonyl-modified Protein Correlate with Severity of Chronic Obstructive Pulmonary Disease
Authors: Paul A. Kirkham, Ian M. Adcock, Kian F. Chung, Peter J. Barnes, Mike Yeadon, Gaetano Caramori, Alberto Papi
Journal: American Journal of Respiratory and Critical Care Medicine (2012)
Stressor Specificity of Sex Differences in Hypothalamo-Pituitary-Adrenal Axis Activity: Cortisol Responses to Exercise, Endotoxin, Wetting, and Isolation/Restraint Stress in Gonadectomized Male and Female Sheep
Authors: A. I. Turner, E. T. A. Rivalland, I. J. Clarke, A. J. Tilbrook
Journal: Endocrine Reviews (2010)

Abstract Sex differences in the stress-induced activity of the hypothalamo-pituitary-adrenal axis in sheep appear to be dependent on the stressor encountered and occur irrespective of the presence of gonadal steroids. We tested the hypotheses that cortisol responses to exercise, endotoxin, wetting (experiment 1), and isolation/restraint (experiment 2) stress differ between gonadectomized male and female sheep. At weekly intervals (in experiment 1), we subjected gonadectomized rams and ewes (n = 6/group) to control conditions, to exercise stress, to iv injection of endotoxin, and to wetting stress. In a second experiment (experiment 2), we subjected gonadectomized rams and ewes (n = 5/group) to control conditions or to isolation/restraint stress. In both experiments, we measured plasma concentrations of cortisol before, during, and after stress at a frequency of at least 15 min with samples collected (from an indwelling jugular catheter) at a greater frequency around the time of the stressor. Cortisol responses to wetting (experiment 1) and isolation/restraint (experiment 2) stress were significantly higher in females compared with males but in response to exercise (experiment 1) and endotoxin (experiment 1) stress, there were no differences between the sexes. For some stressors, there are sex differences in sheep in the stress-induced activity of the hypothalamo-pituitary-adrenal axis that are independent of the presence of the sex steroids, but the existence of these sex differences and the direction of these sex differences differs, depending on the stressor imposed.
Clinical Endocrinology
Authors: A. R. Colwell
Journal: JAMA (1974)

Directed at senior medical and postgraduate students, this sensible text succinctly reviews the essentials of endocrinology. It stresses the interrelationships between the various organs, with a view to preventing disabling complications by early diagnosis and therapy. Aided by several experts in calcium, sex glands, and other fields, the authors offer practical clinical information interspersed with basic physiological concepts. Anatomical and embryological descriptions introduce each section. Simple diagrams illustrate the circulatory, biochemical, and hormonal functions; and important features of the diseases—acromegaly, ovarian tumors, and diabetes—are conveniently tabulated. Methods for endocrine testing present the steps briefly and specifically with references and doses of test agents. The section on the hypothalamus portrays the factors influencing the pituitary and thyroid axis. Use of the alternate-day therapy is omitted from the corticosteroid section. The book is thus deficient in some respects, but other portions have been improved, eg, the role of prostaglandins in pregnancy. Excellent
Film Reviews
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hazardous Solid Wastes Generated in the Cleanup of Air and Water
Authors: Merril Eisenbud
Journal: Environmental Health Perspectives (1978)

Air and water pollution control programs sometimes result in production of solid wastes that are difficult to manage. The sludges from sewage treatment plants and flue gas scrubbers are two examples. In many coastal communities, there is no alternative to ocean dumpling of sewage sludges for the foreseeable future. The use of sludges as soil conditioners, their conversion to fuels by pyrolysis, and other alternatives are frequently mentioned options, but they have not been demonstrated to be practical on a large scale. The Federal requirement that ocean dumping be terminated by 1981 presents the large seaboard population centers with a dilemma, due to the absence of economically feasible alternative methods of disposal. Another major solid waste problem is arising from the Federal policy that requires flue gas desulfurization on practically all power plants. This policy, designed to reduce sulfur oxide emissions, will require that vast quantities of sludge be stored. Their environmental impact is as yet not fully evaluated. Commercial use of the sulfur or sulfates produced in these processes may be possible, but its practicability on a large scale remains to be demonstrated.
Elevated levels of plasma C-reactive protein and tissue plasminogen activator antigen are associated with increased frequency of grade 3 rejection in cardiac transplant recipients Marc S. Eisenberg, Robert R. Sciacca, Hong Jun Chen, Mark K. Warshofsky, Allan Schwartz, LeRoy E. Rabbani. Columbia University College of Physicians and Surgeons, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Lifelong follow-up being urged for patients with cryptorchidism
Authors: P. Gunby
Journal: JAMA (1980)

Health professionals are taking renewed interest in testicular germ cell tumors partly as a result of a new focus on the problem of undescended testes, a condition that affects about one in every 400 to 500 men. Discovery that one or both testicles have failed to descend usually results in earlier treatment now than it did even a few years ago. However, there are indications that, particularly if the treatment involves orchiopexy, previously cryptorchid men must be examined regularly, perhaps for life, because of an increased risk of testicular cancer. This risk is variously estimated to be from 15 to 40 times greater than in men whose testes have descended normally. Though testicular cancer probably accounts for less than 2% of all cancers, it is the third leading cause of death from cancer among men aged 15 to 34 years in this country. The latest work on the problem comes
NEW IMMUNITY TERMS.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4457: Open science medicinal chemistry: Towards a treatment for DIPG
Authors: Sue Cramp, Nicole Hamblin, Jeff O'Meara, Aled Edwards, Owen Roberts, Alex Bullock, Paul Brennan
Journal: Cancer Research (2019)

Abstract Meds4Kids Pharma (M4K)1 is pioneering an open science approach to drug discovery, focussed on the discovery and development of small molecule therapeutics for orphan paediatric cancers. M4K seeks to test the hypothesis that an open science framework can be successfully applied not only to accelerate basic science, using the collective knowledge of the scientific community at large, but also to take an innovative new drug candidate all the way from discovery and clinical proof-of-concept through to product registration, by making use of regulatory data protections and market incentives. Since late 2017, Charles River Early Discovery has been providing in kind drug discovery services to help progress these efforts, including medicinal and synthetic chemistry. The first M4K project aims to generate an orally-available, brain-penetrant therapeutic to treat the diffuse intrinsic pontine glioma (DIPG). DIPG is a rare, aggressive and uniformly fatal childhood brain cancer with a median survival time of 9-12 months and for which there are currently no effective drug treatments. The disease has been shown to be associated with mutations in the ACVR1 gene (activin A receptor, type 1) also known as ALK2 kinase. Early support for the therapeutic hypothesis that an inhibitor of ALK2 kinase would have clinical benefit in DIPG, came from in vivo studies with non-selective ALK2 kinase inhibitors, which both killed DIPG cell lines harbouring the ALK2 mutation and extended lifespan in xenograft mouse models.2 Working collaboratively with M4K and their open science partners, we have made excellent progress towards the identification of potent, selective, brain penetrant ALK2 inhibitors starting from the known inhibitor LDN-214117, previously described for FOP (fibrodysplasia ossificans progressiva).3 Our current lead compound has an excellent in vitro and in vivo profile showing high oral bioavailability and brain penetration in a mouse PK study and is progressing to proof of concept studies. In addition we are progressing with the identification of a back-up series. References: 1. https://m4kpharma.com/ 2. Carvalho et. al. Neuro-Oncology, Volume 18, Issue suppl_6, 1 November 2016, Pages vi154, https://doi.org/10.1093/neuonc/now212.639 3. Mohedas et. al., J. Med Chem, 2014, 57 (19), 7900 Citation Format: Sue Cramp, Nicole Hamblin, Jeff O'Meara, Aled Edwards, Owen Roberts, Alex Bullock, Paul Brennan. Open science medicinal chemistry: Towards a treatment for DIPG [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4457.
Chronic discoid lupus in children
Authors: R. K. Winkelmann
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I should like to provide further follow-up on the patient referred to as case 1 in our study on chronic discoid lupus erythematosus in children (<b>205</b>:675, 1968). Fever, arthralgia, weakness, and Raynaud's phenomenon developed in this patient at age 12, and for the first time there was a positive lupus erythematous (LE) clot test. Albuminuria, anemia, and the diagnosis of systemic lupus erythematosus was made. The patient was treated with corticosteroids which were discontinued when remission was achieved. At the age of 15 the patient was admitted to the hospital with a recurrence of similar symptoms, leukopenia, elevated sedimentation rate, positive LE clot preparations, and marked urinary sediment. He was treated with azathioprine (Imuran) and prednisone. Oral ulcerations developed and the patient died. Autopsy examination performed by Dr. H. Marshall at the University of Kansas Medical Center revealed Libman-Sacks endocarditis, myocarditis and pericarditis, fibrous perisplenitis, typical
Abstract 203: Pseudosemiglabrin inhibits tumor angiogenesis and tumor growth of human colon cancer in xenograft mouse models by downregulating endothelial functions, Notch and VEGF pathways
Authors: Loiy E. Ahmed Hassan, Azman Seeni, Amin M. Abdul Majid
Journal: Cancer Research (2019)

Abstract Many antineoplasic agents were identified from natural product. One such agent is (-)-pseudosemiglabrin extracted from aerial parts of Tephrosia apollinea, while significant progress has been made in understanding the antineoplasic and anti-inflammatory of prenylated flavone (-)-pseudosemiglabrin (SSG), little is known about its antiangiogenic and antitumor in vivo. Using rat aortic ring assay and zebrafish model, SSG dramatically suppressed angiogenesis in vitro, ex vivo and in vivo models, SSG profoundly inhibited the outgrowth of new vessels from explants rat aortic ring, moreover it impaired human endothelial cells (HUVEC) migration and formation of capillary-like structure in vitro in none toxic doses. In this study we hypothesize that SSG can hampered tumor angiogenesis and tumor growth of colorectal cancer in ectopically and orthotopically implanted in nude mice, oral administration of SSG (25- 100mg/kg) significantly inhibited colon tumors growth in nude mice. Histological and Immunohistochemistry analysis further revealed that the stained blood vessels and expression of CD31 in xenograft were remarkably decreased in tumors excised from animals treated with SSG. Mechanistically the compound inhibits tumor angiogenesis by downregulation of Notch downstream (NCID); also SSG was found to inhibit VEGF secretion from human cancer cells as well as endothelial cells. In conclusion, the results demonstrated an original role of (-)-pseudosemiglabrin in inhibiting tumor angiogenesis and tumor growth via inhibition Notch and VEGF pathways. This study also validates the central role of Notch in tumor angiogenesis and suggests that (-)-pseudosemiglabrin could be a potential therapeutic candidate for cancer and other angiogenesis related diseases. Note: This abstract was not presented at the meeting. Citation Format: Loiy E. Ahmed Hassan, Azman Seeni, Amin M. Abdul Majid. Pseudosemiglabrin inhibits tumor angiogenesis and tumor growth of human colon cancer in xenograft mouse models by downregulating endothelial functions, Notch and VEGF pathways [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 203.
PSYCHIC CONTAGION OF CRIMINAL IMPULSE.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The AMA Specialty Journals: Everyone, Including Grunts, Squeals Unfair
Authors: Stuart A. Shapiro
Journal: JAMA (1990)

<h3>To the Editor. —</h3> I am writing to respond to the recent editorial by Springer et al<sup>1</sup>concerning AMA specialty journal readership. The authors present statistics relating to "specialty" readership of the AMA<i>Archives</i>journals. However, they broadly dismiss a vast plurality of the AMA readership—physicians like myself in general or family practice. When the AMA implemented its "controlled circulation policy" on January 1, 1988, physicians who did not fall into predetermined specialty categories were summarily denied their previous choice of journals. Under the old policy, generalists could choose a different<i>Archives</i>journal each year, thereby receiving an overview of a variety of medical fields. The editorial highlights an increase in paid subscribers to<i>Archives</i>journals since the implementation of this new policy. My hunch is that the greater part of these paid subscriptions are from family practitioners, general practitioners, and others who were "shut out" on January 1,1988.
基于全国代表性样本首次评估室内美黑行为成瘾筛查仪
Authors: K. Diehl, T. Görig, E.W. Breitbart, R. Greinert, J.J. Hillhouse, J.L. Stapleton, S. Schneider
Journal: British Journal of Dermatology (2018)

既往研究表明室内美黑可能成瘾。目前存在不同的室内美黑成瘾筛查仪器,但研究表明,这些仪器并非都适用于衡量使用者是否具有室内美黑成瘾倾向。鉴于此,新的仪器应时而生,即室内美黑行为成瘾筛查仪 (BAITS)。这项在德国开展的研究旨在探索 BAITS 仪器是否适合筛查表现出室内美黑成瘾倾向的个体。该研究依据的数据来自针对日光床使用的全国癌症辅助监测 (NCAM),包括认知访谈以及全国范围代表性电话调查。统计分析表明 BAITS 似乎是有效且可靠的工具。经筛查,共 19.7% 的当前日光床使用者以及 1.8% 的以往日光床使用者表现出室内美黑成瘾倾向。但是,这并非室内美黑成瘾的最终判断。最终判断还有待更加正规的评估。但是,BAITS 有助于医生以及医疗服务人员确定特别需要特定咨询的个体,以避免其持续使用日光床。此外,由于 BAITS 筛查时间短且问题容易回答,因此方便在大规模调查中使用。
Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection
Authors: Y Sumida, T Nakashima, T Yoh, Y Nakajima, H Ishikawa, H Mitsuyoshi, Y Sakamoto, T Okanoue, K Kashima, H Nakamura, J Yodoi
Journal: Journal of Hepatology (2000)