tbuckley/cabot-search huggingface dataset:
Das Problem des Charakteraufbaus; seine Gestaltung durch die erbbiologische Persönlichkeitsanalyse.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HELP FOR THE BLIND
Journal: JAMA (1952)

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Pancreatic retention cyst. A cause of obstructive jaundice
Authors: T. A. Loludice
Journal: JAMA (1977)

PANCREATIC retention cysts have not previously been known to cause obstructive jaundice. Recently, we observed a patient in whom a pancreatic retention cyst, located in the second portion of the duodenum, caused obstruction to bile flow. <h3>Report of a Case</h3> A 54-year-old man was in good health until three weeks before admission, when he noted sharp, nonradiating midepigastric pain accompanied by nausea and emesis. The pain was not relieved by antacids or food. From this time, the patient also noted the appearance of dark urine, light stools, and jaundice. He had no history of alcohol abuse or exposure to hepatitis. He had lost 3.6 kg during the previous month. Physical examination showed a thin, jaundiced man in no severe distress. Abnormal findings were confined to the abdomen, which was soft, but tender to palpation in the midepigastric area and right upper quadrant. The vertical liver span was 14 cm, and
EVEN COUNTRY LIFE MAY HAVE SHORTCOMINGS
Journal: JAMA (1924)

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Amniocentesis
Journal: JAMA (2000)

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Manual of the Diseases of the Eye. For Students and General Practitioners, with 275 Original Illustrations, Including 36 Colored Figures.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract LB-078: RNAi and CRISPR/Cas9-based in vivo models for drug discovery
Authors: Prem K. Premsrirut, Christof Fellmann
Journal: Cancer Research (2015)

Abstract Genetically engineered mouse models (GEMMs) are a powerful platform that enable the study of disease initiation and maintenance, the microenvironment and the responsiveness of disease to known or novel therapeutics; however, the long lead times and high costs required to develop, intercross and maintain models with various disease predisposing gene combinations have limited their practical utility in the drug discovery process. RNA interference (RNAi), a mechanism that controls gene expression, is a rapid and cost-effective alternative to gene deletion that can be exploited experimentally to reversibly silence nearly any gene target not only in vitro but also in live mice. By using our “Sensor assay” to biologically identify short hairpin RNAs (shRNAs) that induce potent gene suppression in combination with a new miRNA scaffold, miR-E, we have engineered a reliable system for in vivo gene suppression. Furthermore, by utilizing tetracycline-regulated miR-E based shRNAs with high efficiency ES cell targeting, we have developed a fast, scalable pipeline for the production of shRNA transgenic mice with reversible gene silencing. Recently, with the advent of new genome editing techniques, such as CRISPR/Cas9 technology, we are able to introduce additional sensitizing lesions to induce disease pathogenesis. In synergy with RNAi technology, complex multi-allelic ESC based GEMMs can be generated without extensive intercrossing. Using this combination of CRISPR/Cas9 and RNAi technologies, we are able to not only model disease pathogenesis, but also mimic drug therapy in mice, giving us unprecedented capabilities to perform preclinical studies in vivo. Here, we demonstrate that RNAi in combination with CRISPR/Cas9 genome editing enables us to recapitulate the phenotypes of knockout mice and further explore potential therapeutic approaches within the same model. Using our robust system, we have created a a cost-effective and scalable platform for the production of complex GEMMs with RNAi silencing of nearly any gene - mice with enormous predictive power that will shape our development of better tolerated therapies. Citation Format: Prem K. Premsrirut, Christof Fellmann. RNAi and CRISPR/Cas9-based in vivo models for drug discovery. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-078. doi:10.1158/1538-7445.AM2015-LB-078
Upside-Down ECG's
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DMSO Ban: Was It Handled Properly?
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress in Development of Immunization Registries--United States, 1999
Journal: JAMA (2000)

Community-based and state-based immunization registries are confidential, population-based, computerized information systems that contain data about children's vaccinations and represent an important tool to increase and sustain high vaccination coverage. Immunization registries consolidate vaccination records for children from multiple providers, provide a vaccination needs assessment for each child, generate reminder and recall vaccination notices, produce an official vaccination record, and provide practice-specific and community-based vaccination coverage assessments. One of the Healthy People 2010 national objectives is to increase to 95% the proportion of children aged <6 years who are enrolled in a fully operational population-based immunization registry. To assess the status of immunization registry development, CDC analyzed data from the 1999 Immunization Registry Annual Report (IRAR) of 64 jurisdictions (grantees) that receive federal immunization funds under section 317d of the Public Health Service Act. Findings from this analysis indicate that substantial progress has been made in the United States in developing and implementing community-based and state-based immunization registries.
Association News
Authors: Charles Harrington
Journal: JAMA (1906)

<h3>THE BOSTON SESSION.</h3><h3>Announcement of Headquarters and List of Hotels, with Prices.</h3> While Boston is liberally supplied with hotels of the first class, many of which are in the immediate neighborhood of the meeting places selected by the Committee of Arrangements for the annual session of the American Medical Association, June 5-8, 1906, the Committee on Hotels deems it wise to bring to the notice of those expecting to attend, the advisability of securing accommodations well in advance, since the time chosen for the session is not far from the commencement days of Harvard, Tufts, Boston University and the Massachusetts Institute of Technology, and during the same week it is expected that Eddyites to the number of some thousands will visit Boston to open a new "temple." The committee urges members of the Association, therefore, not to postpone too long the securing of rooms, and it engages to act in
Uropathology
Authors: Randolph A. Hennigar
Journal: JAMA (1990)

At last, a totally comprehensive textbook of uropathology is at hand!<i>Uropathology</i>is the culmination of years of work on the part of the editor, Dr Gary Hill, friend and protégé of the internationally renowned renal pathologist Dr Robert H. Heptinstall. The two-volume set is all-inclusive and discusses the minor and major diseases that affect the entire urogenital system—from the upper pole of the kidneys to the tip of the urethra. The first volume (622 pages) discusses congenital, infectious, inflammatory, and obstructive processes of the urinary tract. The second volume (757 pages) discusses neoplasms of the kidney, ureter, and bladder and lesions of the testis, paratesticular structures, vas deferens, seminal vesicle, prostate, penis, and scrotum. In general, both volumes are well written and well organized. The information is sound and up-to-date. Most chapters are written in a conceptual fashion and include the most recent advances and, where appropriate, the newest
Reply
Authors: Scott W. Fosko, Kurt S. Stenn, Jean L. Bolognia
Journal: Journal of the American Academy of Dermatology (1993)

We thank Drs. Trileb, Bruckner-Tuderman, and Burg for their reportof a patient withthe EEC syndrome and scalp dermatitis.In our article we stated that scalp dermatitis can be seen in patients with the Rapp-Hodgkin,Bowen-Armstrong, andAECsyndromes.Thisstatement wasbasedon an analysisof casesreported in the literature.We also noted that patients with the ABC syndrome were 6.6 timesmore likely to have scalp dermatitis than patients with the Rapp-Hodgkin syndrome.
Integrated Biochemical and Computational Approach Identifies BCL6 Direct Target Genes Controlling Multiple Pathways in Normal Germinal-Center B Cells
Authors: Masumichi Saito, Katia Basso, Pavel Sumazin, Adam A Margolin, Kai Wang, Wei-Keat Lim, Andrea Califano, Riccardo Dalla-Favera
Journal: Blood (2008)
Maintaining Hospital Quality
Authors: Robert H. Brook
Journal: JAMA (1993)

NOT long ago, hospitals were considered places to die. More recently, with the introduction of modern surgery and medication, hospitals became safe places in which many people obtained substantial benefit. Today, hospitals are perceived from conflicting perspectives. On the one hand, they are places where lives are saved. On the other hand, they are places where enormous amounts of money are spent and the cost-effectiveness of these expenditures is being questioned, and where some "care" provided there is of no benefit or even harmful. These latter perceptions have led some governments to reduce the growth in hospital funding. This, in turn, has led to unnecessary deaths, increased complication rates, and long waits for elective surgical procedures that are performed to alleviate pain and improve functional status. Hospital quality could decline further if changes in health policy do not explicitly attempt to maintain it.<sup>1,2</sup> While the perception of the hospital's
Triamterene Nephrolithiasis
Authors: Bruce Ettinger
Journal: JAMA (1980)

We identified triamterence in 181 renal calculi (o.4% of 50.000 calculi submitted for analysis). Triamterene formed the nucleus of the stone or was deposited with calcium oxalate or uric acid. One third of these stones were mainly or entirely triamterene, though a similar proportion had only minor amounts. A recommended dose of triamterene-hydrochlorothiazide sufficed to produce triamterene deposition in renal calculi. We estimate the annual incidence of the complication to be one per 1,500 users of triamterene-hydrochlorothiazide. Triamterene lithiasis develops particularly in persons who have had a renal stone, and they should not receive this drug.
From the authors
Authors: P.A. de Jong, M.H. Lequin, J.R. Mayo, P.D. Paré, H.A.W.M. Tiddens
Journal: European Respiratory Journal (2004)

Progressive damage on high-resolution computed tomographyTo the Editors:We were interested to read the article by DE JONG et al. [1].We are writing to you following enquiries by a number of clinical colleagues who have expressed concerns regarding the regular use of a high-dose technique (i.e.high-resolution computed tomography) with groups of young patients and the implications for the substantial radiation doses that may result.The clinical potential of the procedure has, we are sure, been clearly shown.However, given the very high radiation doses involved and the young age of these patients, there is concern that relatively little information had been given to allow adequate justification of this procedure, in accordance with the relevant European directive [2], which concerns the health protection of individuals against the dangers of ionising radiation in relation to medical exposures.We would be interested to hear the authors9 views, and, in particular, whether they are able to provide any information to allow a formal risk-benefit analysis to be carried out.
CORRECTION
Authors: R Arasaradnam, R Bolton, A Floreani, J Newton, F James, F Bassendine, E Jones, D Jones, P Roberts, S Middleton, A Perner, L Andresen, J Rask-Madsen
Journal: Gut (2002)

Hypomagnesaemia due to malabsorption is not always responsive to oral magnesium oxide supplementation aloneWe read with interest the Gut File report by Dr Ross and colleagues of hypomagnesaemia due to malabsorption, eventually responding to oral magnesium oxide supplementation (Gut 2001;48:857-8).Our experience however has been different.For the past seven years we have managed a 65 year old woman with short bowel syndrome (right hemicolectomy for Duke's C colorectal carcinoma and thereafter a terminal ileal resection for abscess formation).High ileostomy output was initially difficult to manage (after excluding infection, secreting gut hormone tumours by normal hormone levels, and despite dietary and pharmacological modifications).Clinical signs of hypomagnesaemia and hypocalcaemia ensued.An initial trial with magnesium glycerophosphate (September 1992 to December 1993) was insufficient to sustain her serum magnesium levels requiring frequent "top ups" of intravenous magnesium. 1In December 1993, she was switched to magnesium oxide supplementation but despite this the frequency of intravenous magnesium "top ups" were not reduced.Compliance was not deemed to be an issue with our patient.Since then we have managed this woman while still taking magnesium oxide supplements with almost 3-6 monthly (fig 1) intravenous magnesium replacement through a peripheral line and have avoided insertion of a Hickman line and all its associated complications. 2 While we agree that a trial of magnesium oxide is prudent and until the pharmacokinetics are better understood, this preparation may not be sufficient, especially in patients with extensive resection of the small bowel, as demonstrated in our patient.
Abdominal Surgery
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1964)

THE past two years have witnessed an unabated interest in abdominal surgery. The stomach and duodenum, particularly because of investigations related to peptic ulcer, have received the greatest attention. The solution of various problems has been sought in the experimental laboratory much more commonly than in the past, so that reference to many of these contributions will be necessary. Meanwhile, in clinical surgery, a trend toward more conservative procedures has been maintained.Lower Esophagus and CardiaThe esophagogastric junction, on the basis of many recent investigations, has been proved to be an exceedingly complex area. For example, the anatomic junction . . .