tbuckley/cabot-search huggingface dataset:
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1958)

APPLICANTS FOR FELLOWSHIPPublished in Accordance with the Provisions of Chapter V, Section 2 of the By-LawsMiddlesex SouthChalfen, Melvin Howard, 85 Washington Avenue, Cambridge.Tufts University School of Medicine, 1954.Sharpe, William, Jr., 47 Mt. Vernon Street, Cambridge 40. Boston University School of Medicine, 1951.David C. Dow, M.D., Secretary 1587 Massachusetts Ave., CambridgePlymouthGreen, Jack, 65 Richard Road, Braintree. McGill University Faculty of Medicine, 1947.Nalebuff, Edward Alan, 30 Bruce Lane, Newton. Tufts University School of Medicine, 1953.Hyman Duby, M.D., Secretary 345 Court Street, PlymouthCOMMITTEE ON MATERNAL WELFAREChoriocarcinoma, with Invasion of the Urinary . . .
The Greek Genius
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intracranial hemorrhage associated with phencyclidine abuse
Authors: H. A. Bessen
Journal: JAMA (1982)

PHENCYCLIDINE (PCP) is a popular "recreational" drug. Complications of its abuse are myriad and range from mild behavioral disturbances to death.<sup>1-5</sup>Death caused by PCP intoxication is usually due to the "behavioral toxicity" of the drug.<sup>1,2</sup> A case of massive intracranial hemorrhage in a PCP-intoxicated patient is reported herein. Aside from the effects of the drug, no other cause for the fatal hemorrhage could be determined. <h3>Report of a Case</h3> A 20-year-old man was brought to the emergency department by paramedics. According to the patient's companion, the patient collapsed after smoking "marijuana." The companion had used the same substance without apparent ill effect. On arrival, the patient was deeply comatose. His BP was 180/100 mm Hg; pulse rate, 130 beats per minute; respirations, 26/min. There was a small abrasion above the right eye, with no other signs of trauma. Pupils were initially 2 mm bilaterally. Within a few minutes,
Single cell RNA sequencing and functional in vivo genetic manipulation reveal heterogeneity and tumor-promoting roles of cancer-associated fibroblasts in intrahepatic cholangiocarcinoma
Authors: Silvia Affò, Aashreya Ravichandra, Francesco Brundu, Aveline Filliol, LiKang Chin, Wen Wen, Deqi Yin, Sonakshi Bhattacharjee, Raul Rabadan, Raghu Kalluri, Lars Zender, Rebecca Wells, Xin Chen, Robert F. Schwabe
Journal: Journal of Hepatology (2020)
Hematology of Infancy and Childhood
Authors: Ruth Andrea Seeler
Journal: JAMA (1981)

The classic pediatric hematology text, with everything you ever wanted to know but could not find or remember where you had filed it, is now conveniently located within two volumes. It is exciting but sobering to realize that within seven years, the core scientific knowledge of pediatric hematology has doubled. These volumes are a smooth integration of cellular biology, physiology, and biochemistry with their logical extension to clinical manifestations. Pediatric hematology is really nothing more than the practice of applied basic science. Now, the reader has it all together. In addition to the editors, 57 world-renowned experts have contributed to this encyclopedic text. Nevertheless, an extremely high literary standard is maintained throughout. One author's style shines with masterful skill in the chapter on RBC maturation (normally pure drudgery to read). Don't skip the introductory, historical perspective; surrounded by our scanning and transmission electron microscopes, and radioimmunological techniques, we lose sight
Erratum: Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both
Authors: Masahiro Akiyama, Takamitsu Unoki, Yasuhiro Shinkai, Isao Ishii, Tomoaki Ida, Takaaki Akaike, Masayuki Yamamoto, Yoshito Kumagai
Journal: Environmental Health Perspectives (2020)

instead of "mM."The authors regret the error.
A Phase 2 Study of Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) Plus Rituximab in Newly Diagnosed, Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma
Authors: Robert W. Chen, Leslie Popplewell, Paul Frankel, Tanya Siddiqi, Joel Conrad, Michelle Mott, Myo Htut, Auayporn Nademanee, Stephen J Forman, Mark Kirschbaum
Journal: Blood (2012)
160. Truncated Vesicular Stomatitis Virus G- Protein Improves Baculovirus Transduction Efficiency In Vitro and In Vivo
Authors: Minna U. Kaikkonen, Jani K. Raty, Kari J. Airenne, Thomas Wirth, Tommi Heikura, Seppo Yla-Herttuala
Journal: Molecular Therapy (2006)

Pseudotyping of viral vectors has been widely used to enhance viral transduction efficiency. One of the most popular pseudotyping proteins has been the G-protein of the Vesicular Stomatitis Virus, VSV-G. In the present study we show that the 21- amino acid ectodomain with transmembrane and cytoplasmic tail domains of VSV-G (VSV-GED) augments baculovirus-mediated gene-delivery in vertebrate cells.VSV-GED baculovirus was efficiently produced and showed improved transduction, as measured by a number of transduced cells or transgene expression level, in five out of six studied cell lines. Moreover, no cytotoxicity was associated with the improved gene transfer efficiency. Increased transduction efficiency was also detected in rat brain and rabbit muscle in vivo. We suggest that the VSV-GED augments baculovirus transduction by augmenting gp64- mediated endosomal escape.VSV-GED pseudotyping provides a simple means to enhance baculovirus-mediated gene transfer in vitro and in vivo. VSV-GED display has several advantages compared to the VSV-G pseudotyping and may also provide a useful tool to augment gene transfer of other viral vectors. Pseudotyping of viral vectors has been widely used to enhance viral transduction efficiency. One of the most popular pseudotyping proteins has been the G-protein of the Vesicular Stomatitis Virus, VSV-G. In the present study we show that the 21- amino acid ectodomain with transmembrane and cytoplasmic tail domains of VSV-G (VSV-GED) augments baculovirus-mediated gene-delivery in vertebrate cells. VSV-GED baculovirus was efficiently produced and showed improved transduction, as measured by a number of transduced cells or transgene expression level, in five out of six studied cell lines. Moreover, no cytotoxicity was associated with the improved gene transfer efficiency. Increased transduction efficiency was also detected in rat brain and rabbit muscle in vivo. We suggest that the VSV-GED augments baculovirus transduction by augmenting gp64- mediated endosomal escape. VSV-GED pseudotyping provides a simple means to enhance baculovirus-mediated gene transfer in vitro and in vivo. VSV-GED display has several advantages compared to the VSV-G pseudotyping and may also provide a useful tool to augment gene transfer of other viral vectors.
Abortion
Authors: Aaron H. Esman
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Dr. Charles Aring's lofty and philosophical COMMENTARY on the subject of abortion (230:231, 1974) is a classic example of the sort of thing that continues to give medicine a bad name. It is incredible to me that he would seriously claim to have been unaware of "undue trouble in having abortion performed competently" after more than 50 years of practice. Can he really be unaware of the hundreds of cases of septic operation that used to occur every year prior to legalization? Can it be that Dr. Aring's practice was limited to women of the upper classes who could afford to pay large sums for "competently performed abortions"? Is he really unaware of the innumerable unwanted children born to mothers of the lower socioeconomic orders because abortion was unavailable to them? Dr. Aring's detached approach to the problem represents, it seems to me, an attitude that medicine
By Instead of To.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction—Eight States, 1998-2005
Journal: JAMA (2008)

Streptococcus pneumoniae (pneumococcus) is a major cause of meningitis, pneumonia, and bacteremia, especially among young children and older adults. Before the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in the United States in 2000, the seven pneumococcal serotypes covered by the vaccine (4, 6B, 9V, 14, 18C, 19F, and 23F) caused 80% of invasive pneumococcal disease (IPD) cases among young children, and the incidence of IPD was relatively stable. In October 2000, the Advisory Committee on Immunization Practices recommended PCV7 for all children aged <2 years and for older children at increased risk for IPD. Introduction of PCV7 in the United States led to substantial reductions in the incidence of IPD among the target population of children aged <5 years. Use of the vaccine also reduced IPD among unvaccinated populations through reductions in nasopharyngeal colonization and transmission of vaccine-type pneumococci from vaccinated children (i.e., indirect, or herd, effects of PCV7). To evaluate the effect of continued PCV7 use on IPD incidence among children aged <5 years in the United States, CDC analyzed population- and laboratory-based surveillance data. Results of that analysis indicated that in 2005, overall IPD rates among children aged <5 years were 77% lower, and an estimated 13,000 fewer cases of IPD occurred, compared with the years preceding vaccine introduction (1998-1999). Although IPD caused by PCV7 serotypes declined through 2005, overall IPD rates leveled off beginning in 2002, primarily because of increases in the incidence of IPD caused by non-PCV7 serotype 19A. Given these trends, use of expanded-valency conjugate vaccines might further reduce IPD incidence. Continued surveillance is needed to guide development of future formulations of conjugate vaccines and to monitor the effects of continued vaccine use.
Hemorrhage into a pheochromocytoma
Authors: L. M. Jacobs
Journal: JAMA (1978)

WE describe the clinical course of a patient and discuss a number of the associated pharmacophysiological effects of massive hemorrhage into a pheochromocytoma. <h3>Report of a Case</h3> A spontaneous hemorrhage into a unilateral adrenopheochromocytoma developed in a previously healthy 28-year-old woman. This led to fulminating pulmonary edema and cardiac failure, which were complicated by disseminating intravascular coagulation resulting in microinfarcts and ischemic necrosis of the brain. In the emergency room, she was nauseated and was vomiting. On examination, her vital signs were blood pressure (BP), 120/80 mm Hg; pulse rate, 124 beats per minute; and respirations, 16/min. She was not in distress. Her oropharynx was unremarkable and her chest was clear. Her abdomen was unremarkable. Within one hour cyanosis and copious, frothy pink hemoptysis developed. A chest x-ray film showed fulminant pulmonary edema. Her blood gas values on 100% oxygen were Pao<sub>2</sub>, 45 mm Hg; Pco<sub>2</sub>, 29 mm
Green-tobacco sickness. An illness of tobacco harvesters
Authors: S. H. Gehlbach
Journal: JAMA (1974)

Tobacco-associated occupational illness occurs regularly in North Carolina tobacco fields. Green-tobacco sickness is a self-limited illness characterized by pallor, vomiting, and prostration. It occurs principally in young men who handle uncured tobacco leaves in the fields. A survey among 53 harvesters who had had green-tobacco sickness and 49 control harvesters was undertaken to define and quantify the symptom complex. The illness was correlated with cropping (picking) the tobacco while it was wet; the absorption of nicotine from the tobacco leaf is the probable cause. Cigarette smoking affords protection against the illness. (<i>JAMA</i>229:1880-1883, 1974)
Diagnostic and therapeutic technology assessment. Garren gastric bubble
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POISONING BY WOOD ALCOHOL.CASES OF DEATH AND BLINDNESS FROM COLUMBIAN SPIRITS AND OTHER METHYLATED PREPARATIONS.
Authors: FRANK BULLER
Journal: JAMA (1904)

<h3>Case 81.</h3> —(From Dr. John E. Weeks, New York City.) E. V., aged 38, came to the New York Eye and Ear Infirmary, Dr. Weeks' service, Nov. 21, 1903. In the early part of August the patient suffered from intermittent fever, and on August 7 he drank a cupful of wood alcohol for the purpose of breaking up the fever. On the following day the vision of the left eye failed almost entirely, and the vision of the right eye became impaired. The maximum failure of vision was reached at the end of 48 hours. Since then, according to the patient's statement, there has been some improvement. At the present time the vision of the right eye equals 30/40; the vision of the left eye equals fingers at eight feet. There is (see Fig. 1) concentric limitation of the field of vision, most marked in the left eye, an absolute central scotoma in the left eye and a relative central scotoma in the right eye.
French, US viral isolates compared in search for cause of AIDS
Authors: C. Marwick
Journal: JAMA (1984)

It still is to be determined if French and American investigators have isolated the same virus—or if there are substantial differences in their isolates—in the search for the cause of acquired immune deficiency syndrome (AIDS). However, there is mounting belief that the retrovirus recently identified by National Cancer Institute (NCI) investigators (Bethesda, Md) and the lymphadenopathy virus (LAV) reported last year by a group at the Institut Pasteur, Paris (<i>JAMA</i>[MEDICAL NEWS] 1983;250:1010-1015), are the same. The final word awaits physical analysis of the two agents. "But, from the pattern of antibody reactions, I would be surprised if there is very much difference," said M. G. Sarngadharan, PhD, of Litton Bionetics, Kensington, Md, a member of the NCI group. Sarngadharan spoke recently at a symposium on infectious agents in blood held by the American Red Cross in Washington, DC. At the same meeting, James Curran, MD, director of the Centers
THE SURGERY OF THE HEART
Journal: JAMA (1924)

Some of the most dramatic chapters in the history of medicine deal with the development of surgery. "A good surgeon must have an eagle's eye, a lion's heart, a lady's hand." Thus runs the old English proverb, formulated in the days before anesthetics banished pain and antiseptics averted the horrors of wound infection. Today no large part of the body is destined to remain free from surgical approach. The abdomen, thorax and cranium have already been invaded by the trained surgeon with eminent success in the relief of a variety of maladies. Blood vessel and nerve surgery have been developed to a high degree of skill. Plastic transformations are being made in varied parts of the body. This progress has called not only for great resourcefulness of hand and mind but also for personal courage. The pioneer into uncharted places usually proceeds at his own peril only; he pays the
Combustion Products of 1,3-Butadiene Are Cytotoxic and Genotoxic to Human Bronchial Epithelial Cells
Authors: W. James Catallo, Christopher H. Kennedy, William Henk, Steven A. Barker, Stephen C. Grace, Arthur Penn
Journal: Environmental Health Perspectives (2001)

Adverse health effects of airborne toxicants, especially small respirable particles and their associated adsorbed chemicals, are of growing concern to health professionals, governmental agencies, and the general public. Areas rich in petrochemical processing facilities (e.g., eastern Texas and southern California) chronically have poor air quality. Atmospheric releases of products of incomplete combustion (e.g., soot) from these facilities are not subject to rigorous regulatory enforcement. Although soot can include respirable particles and carcinogens, the toxicologic and epidemiologic consequences of exposure to environmentally relevant complex soots have not been well investigated. Here we continue our physico-chemical analysis of butadiene soot and report effects of exposure to this soot on putative targets, normal human bronchial epithelial (NHBE) cells. We examined organic extracts of butadiene soot by gas chromatography-mass spectrometry (GC-MS), probe distillation MS, and liquid chromatography (LC)-MS-MS. Hundreds of aromatic hydrocarbons and polycyclic aromatic hydrocarbons with molecular mass as high as 1,000 atomic mass units were detected, including known and suspected human carcinogens (e.g., benzo(a)pyrene). Butadiene soot particles also had strong, solid-state free-radical character in electron spin resonance analysis. Spin-trapping studies indicated that fresh butadiene soot in a buffered aqueous solution containing dimethylsulfoxide (DMSO) oxidized the DMSO, leading to CH(3)* radical formation. Butadiene soot DMSO extract (BSDE)-exposed NHBE cells displayed extranuclear fluorescence within 4 hr of exposure. BSDE was cytotoxic to > 20% of the cells at 72 hr. Morphologic alterations, including cell swelling and membrane blebbing, were apparent within 24 hr of exposure. These alterations are characteristic of oncosis, an ischemia-induced form of cell death. BSDE treatment also produced significant genotoxicity, as indicated by binucleated cell formation. The combination of moderate cytotoxicity and genotoxicity, as occurred here, can be pro-carcinogenic.
An Angiogenic, Endothelial-Cell-Targeted Polymeric Gene Carrier
Authors: W SUH, S HAN, L YU, S KIM
Journal: Molecular Therapy (2002)

Targeting is one of the primary considerations in designing a specific and efficient gene delivery system. Here, an angiogenic endothelial cell-targeted polymeric gene delivery carrier was developed by conjugating an αvβ3/αvβ5 integrin-binding RGD peptide, ACDCRGDCFC, into the cationic polymer polyethyleneimine (PEI) via a hydrophilic poly(ethylene glycol) (PEG) spacer. The incorporation of PEG into PEI improved the poor physicochemical properties of PEI–DNA complexes. At a neutral charge ratio, DNA complexes with PEI were polydisperse and substantially aggregated, whereas DNA complexes with PEI-g-1PEG-RGD were homogeneous with 100–200 nm effective diameter. Their surface charge was also significantly reduced due to the charge shielding effect of PEG. However, the extensive grafting of PEI with PEG was shown to inhibit the DNA condensation process, significantly decreasing transfection efficiency. In in vitro transfection experiments with angiogenic endothelial cells, PEI-g-1PEG-RGD showed an approximately fivefold increase in transfection efficiency over PEI, due to an integrin-mediated internalization pathway. PEI-g-1PEG-RGD also exhibited high specificity to angiogenic endothelial cells compared with normal endothelial cells, which was confirmed by in vitro transfection experiments with non-targeting PEI-g-1PEG-RAE in angiostatic endothelial cells.
RECENT WORK ON THE BACTERICIDAL ACTION OF SERUM OF ANIMALS SUSCEPTIBLE TO ANTHRAX.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal