tbuckley/cabot-search huggingface dataset:
A Fungus Oddball
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: Journal of Clinical Oncology (2021)

subheading of the Results section read as: Twenty-three events were observed: 10 patients with local-only relapse, nine with distant-only relapse, two with local plus distant relapse, one second malignant neoplasm (epithelioid sarcoma of the floor of the mouth), and one accidental death.This sentence should have read as: Eighteen events were observed: four patients with local-only relapse, ten with distant-only relapse, two with local plus distant relapse; one second malignant neoplasm (epithelioid sarcoma of the floor of the mouth), and one accidental death.This has been corrected as of April 15, 2021.
Perinephric abscess radiologically mimicking dilated bowel
Authors: D. C. Rudy
Journal: JAMA (1983)

<h3>History</h3> A 45-year-old diabetic woman had the acute onset of fever, chills, nausea, vomiting, right flank pain, and dysuria. She was admitted to the referring hospital with diagnoses of poorly controlled diabetes mellitus and gram-negative shock. She was resuscitated with intravenous (IV) fluids, a continuous insulin infusion (insulin zinc suspension), and parenteral antibiotics. A right pleural effusion subsequently developed, and multiple thoracenteses were nondiagnostic. The right kidney could not be visualized in an IV pyelogram. She was transferred to the University of New Mexico Hospital because of persistent fever after two weeks of antibiotic therapy. A plain film of the abdomen demonstrated a localized collection of gas, with an air-fluid level in the upper right quadrant suggesting dilation of the hepatic flexure of the colon or a dilated loop of small bowel (Fig 1). No calcifications were detected. Shortly after admission, a right retrograde pyelogram showed a distorted collecting system,
Where the Chips Fall: Environmental Health in the Semiconductor Industry
Authors: Ron Chepesiuk
Journal: Environmental Health Perspectives (1999)

Three recent lawsuits are focusing public attention on the environmental and occupational health effects of the world's largest and fastest growing manufacturing sector-the $150 billion semiconductor industry. The suits allege that exposure to toxic chemicals in semiconductor manufacturing plants led to adverse health effects such as miscarriage and cancer among workers. To manufacture computer components, the semiconductor industry uses large amounts of hazardous chemicals including hydrochloric acid, toxic metals and gases, and volatile solvents. Little is known about the long-term health consequences of exposure to chemicals by semiconductor workers. According to industry critics, the semiconductor industry also adversely impacts the environment, causing groundwater and air pollution and generating toxic waste as a by-product of the semiconductor manufacturing process. In contrast, the U.S. Bureau of Statistics shows the semiconductor industry as having a worker illness rate of about one-third of the average of all manufacturers, and advocates defend the industry, pointing to recent research collaborations and product replacement as proof that semiconductor manufacturers adequately protect both their employees and the environment.
The Cephalic Phase of Exocrine and Endocrine Pancreatic Secretion
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influenza Vaccine
Authors: GREGORY A. POLAND
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 March 1988Influenza VaccineGREGORY A. POLAND, M.D.GREGORY A. POLAND, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-3-495_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to draw the attention of readers to a persistent error inCecil's Textbook of Medicine, including the newest edition released this month (1). Table 17-2, "Commonly Used Active Immunizing Agents in Adults," states that influenza vaccine should be given annually by the subcutaneous route. Although some research has been done on subcutaneous delivery of influenza vaccine, this is not the established route. Recommendations are now uniformly for intramuscular injection to insure optimal antibody levels. (2-4). Unfortunately, influenza vaccine given subcutaneously may not be as immunogenic and may have greater associated side effects. (5; Unpublished data....References1. WYNGAARDEN J and SMITH L, eds. Cecil Textbook of Medicine. 18th ed. Philadelphia: W. B. Saunders, Co.; 1988:62. Google Scholar2. Recommendation of the Immunization Practices Advisory Committee (ACIP): prevention and control of influenza. MMWR. 1987;36:373-87. MedlineGoogle Scholar3. RUBEN F. Prevention and control of influenza: role of vaccine. Am J Med. 1987;82(suppl 6A):31-4. CrossrefMedlineGoogle Scholar4. . Guide for adult immunization. Philadelphia: American College of Physicians; 1985. Google Scholar5. BARRY D, MAYNER R, and HOCHSTEIN H. Comparative trials of influenza vaccines: II. Adverse reactions in children and adults. Am J Epidemiol. 1976;104:47-59. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GREGORY A. POLAND, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdult ImmunizationReaders' Forum 1 March 1988Volume 108, Issue 3 Page: 495-495 Keywords Intramuscular injections Vaccines ePublished: 1 December 2008 Issue Published: 1 March 1988 PDF downloadLoading ...
Darolutamide Slows Metastasis in Prostate Cancer
Journal: Cancer Discovery (2019)

The phase III ARAMIS study shows that the androgen-receptor antagonist darolutamide delays metastasis in men with castration-resistant prostate cancer by a median of 22 months compared with a placebo. Researchers also found that side effects associated with other drugs in this class were no more common in the placebo group than the darolutamide group.
Response
Authors: A. S. WHITTEMORE, R. S. PAFFENBARGER, L. N. KOLONEL, J. HANKIN, A. H. WU, E.M. JOHN, D. W. WEST, R. P. GALLAGER, C.-Z. TEH, G. R. HOWE, J. D. BURCH, D. M. DREON
Journal: JNCI Journal of the National Cancer Institute (1995)
Multivariate analysis including biomarkers in the phase III RADIANT-2 study of octreotide LAR plus everolimus (E+O) or placebo (P+O) among patients with advanced neuroendocrine tumors (NET).
Authors: James C. Yao, John D. Hainsworth, Edward M. Wolin, Marianne E. Pavel, Eric Baudin, David Gross, Philippe Ruszniewski, Paola Tomassetti, Ashok Panneerselvam, Stephen Saletan, Judith Klimovsky
Journal: Journal of Clinical Oncology (2012)

157 Background: In this large phase III trial, median progression-free survival (PFS) improved by 5.1 mo with E+O compared to P+O in patients (pts) with NET associated with carcinoid syndrome. Randomization imbalances including WHO performance status (PS), and primary site favoring P+O confounded primary analysis. Chromogranin A (CgA) and 5-hydroxyindoleacetic acid (5-HIAA) are important biomarkers in NET. Analyses were performed to identify prognostic factors and adjust for randomization imbalances. Methods: Pts were randomized to E+O (n=216) or P+O (n=213). Potential prognostic factors including baseline CgA (≤2×ULN vs &gt;2×ULN), baseline 5-HIAA (≤median vs &gt;median), age (&lt;65 vs ≥65), gender, race, WHO PS (0 vs 1, 2), primary site (lung vs other), prior somatostatin analog use (yes vs no), duration from diagnosis (&lt;6 mo, 6-24 mo, 2-5 yr, &gt;5 yr), and organs involved (liver, bone) were assessed in univariate analysis using the log rank test and a stepwise regression using Cox proportional hazards model. Results: Randomization resulted in significant imbalance in baseline CgA (median [ng/mL], 251 E+O vs 137 P+O). Median PFS (mo) was significantly longer for pts with nonelevated CgA (27 vs 11; P&lt;.001) and nonelevated 5-HIAA (17 vs 11; P&lt;.001). Analyses also indicated age (14 vs 12; P=.01), WHO PS (17 vs 11; P=.004), liver involvement (14 vs not reached; P=.02), bone metastases (8 vs 15; P&lt;.001), and lung as primary site (11 vs 14; P=.06) as potentially prognostic. Multivariate analysis indicated that significant prognostic factors for PFS included baseline CgA (HR, 0.47; CI, 0.34-0.65; P&lt;.001), WHO PS (HR, 0.69; CI, 0.52-0.90; P=.006), bone involvement (HR, 1.52; CI, 1.06-2.18; P=.02), and lung as primary site (HR, 1.55; CI, 1.01-2.36; P=.04). Adjusted for covariates, a 38% reduction in risk of progression was observed for E+O (HR, 0.62; 95% CI, 0.51-0.87; P=.003). Conclusions: In the phase III RADIANT-2 trial, baseline CgA levels, WHO PS, lung as primary site, and bone involvement were important prognostic factors. Exploratory analysis adjusted for these prognostic factors indicated significant benefit for everolimus therapy.
Characteristics and outcome of octogenarian versus young patients (pts) with metastatic castrate resistant prostate cancer (mCRPC) treated with ketoconazole.
Authors: Victoria J. Sinibaldi, Michal Dadon-Nachum, Maya Gottfried, Natalie Maimon, Zamir Dovrish, Avivit Peer, Avivit Neumann, Avishay Sella, Svetlana Kovel, Michael Anthony Carducci, Mario A. Eisenberger, Daniel Keizman
Journal: Journal of Clinical Oncology (2014)

e16068 Background: Standard treatment options for pts with mCRPC include docetaxel based chemotherapy, abiraterone, and radium 223. Octogenarian pts (aged ≥ 80) are often considered to be unfit for chemotherapy. However, recommendations for their management is limited by the paucity of clinical trials data in this population. In countries where abiraterone in the pre-chemotherapy setting has not been approved yet, or for pts who can’t afford it, the CYP 17 inhibitor ketoconazole is used as an alternative advanced hormonal tx. We aimed to study baseline characteristics and outcome of octogenarian vs young (aged ≤60) pts with mCRPC treated with ketoconazole. Methods: We performed an international multicenter retrospective study of pts with mCRPC, who were treated with ketoconazole at 4 centers across 2 different countries. We compared baseline characteristics and outcome of octogenarian versus young pts. The effect of very old age on PSA response, progression free survival (PFS) and overall survival (OS), was tested with adjustment of other known confounding risk factors using a chi-square test and partial likelihood test from cox model. Results: Between 2004-2013, 35 octogenarian (median age 83) and 33 young (median age 57) mCRPC were treated with ketoconazole. The groups were balanced regarding the following baseline clinicopathologic characteristics: extent of disease (limited-axial skeleton and/or nodal versus extensive- appendicular skeleton and/or visceral), combined gleason score, pre-treatment risk category (Keizman, Oncologist 2012; based on pre-tx neutrophil to lymphocyte ratio/PSADT, and prior response to ADT), pain intensity, ECOG performance status, alkaline phosphatase level, hemoglobin level, PSA level. In octogenarian versus young, PSA response (≥ 50% decline from baseline) was 40% vs 61% (OR 3.5, p=0.04), median PFS 7 vs 8 months (HR 1.69, p=0.194), and median OS 31 vs 41 months (HR 4.49, p=0.034). Conclusions: In very old vs young mCRPC patients treated with ketoconazole, PSA response was lower and overall survival shorter. Baseline clinicopathologic characteristics and PFS were not significantly different between the groups.
From the Food and Drug Administration
Authors: Stuart L. Nightingale
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Congenital Aortic Stenosis. Correlation of Clinical Severity with Hemodynamic and Surgical Findings in Forty-Three Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stat Bite: Cancer and Heart Disease Deaths
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Stat Bite: Cancer and Heart Disease Deaths Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 16, 16 August 1995, Page 1206, https://doi.org/10.1093/jnci/87.16.1206 Published: 16 August 1995
Branching Morphogenesis
Authors: Arie Horowitz, Michael Simons
Journal: Circulation Research (2008)

Tubular structures are a fundamental anatomic theme recurring in a wide range of animal species. In mammals, tubulogenesis underscores the development of several systems and organs, including the vascular system, the lungs, and the kidneys. All tubular systems are hierarchical, branching into segments of gradually diminishing diameter. There are only 2 cell types that form the lumen of tubular systems: either endothelial cells in the vascular system or epithelial cells in all other organs. The most important feature in determining the morphology of the tubular systems is the frequency and geometry of branching. Hence, deciphering the molecular mechanisms underlying the sprouting of new branches from preexisting ones is the key to understanding the formation of tubular systems. The morphological similarity between the various tubular systems is underscored by similarities between the signaling pathways which control their branching. A prominent feature common to these pathways is their duality--an agonist counterbalanced by an inhibitor. The formation of the tracheal system in Drosophila melanogaster is driven by fibroblast growth factor and inhibited by Sprouty/Notch. In vertebrates, the analogous pathways are fibroblast growth factor and transforming growth factor-beta in epithelial tubular systems or vascular endothelial growth factor and Notch in the vascular system.
Protecting privacy of computerized patient information may lie in the cards
Authors: A. A. Skolnick
Journal: JAMA (1994)

NO MATTER which—if any—sort of national health care system reform is finally adopted by Congress, it is almost certain to bring about a great change in the way patient information is gathered, stored, and used for patient care, for medical and social research, and for physician and hospital reimbursement. The shift from paper to computerized recordkeeping, which is virtually mandated by health care system reform, promises not only greater efficiency and cost savings but increased concerns about the threat to patient privacy. Such concerns have not been lessened by reports of recent breaches of computer security that could have been disastrous for the patients involved. For example, the theft of three computers and floppy disks from Jackson Memorial Hospital in Miami, Fla, last November, suggests how harmful such breaches can be. Stored in the computers and on the disks were the names of more than 7000 patients who had received
Hematuria caused by varicella lesions in the bladder
Authors: A. D. Amar
Journal: JAMA (1966)

HEMATURIA resulting from chickenpox lesions must be rare indeed. It is not mentioned in any of several pediatric textbooks,<sup>1-3</sup>or in the current edition of<i>Viral and Rickettsial Infections of Man</i><sup>4</sup>; and I have not been able to find a report of such an event. In a patient with hematuria and varicella, bleeding per urethra may be related to chickenpox lesions in the bladder, as exemplified in the following case. <h3>Report of a Case</h3> A 5-year-old boy was admitted to the hospital because of urinary frequency, dysuria, and passage of blood clots from the urethra, of four hours' duration. The mother reported that the child had been feverish and lethargic since the outbreak of varicella rash nine days before. His temperature was normal throughout his hospital stay. Scattered over the skin were chickenpox lesions in stages of crust formation and crust separation. A lesion on the chest, with
Seventeenth Annual San Francisco Cancer Symposium
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Seventeenth Annual San Francisco Cancer Symposium Get access JNCI: Journal of the National Cancer Institute, Volume 67, Issue 5, November 1981, Page 1177, https://doi.org/10.1093/jnci/67.5.1177-a Published: 01 November 1981
Highlights
Journal: JAMA Pediatrics (2015)

Delayed cord clamping reduces the risk for subsequent iron defi ciency during the fi rst 4 months of life and can potentially result in improved neurodevelopment.Andersson and colleagues follow up 263 children at low risk for iron defi ciency in a randomized clinical trial of delayed cord clamping compared with early clamping to examine their neurodevelopmental outcomes at age 4 years.Delayed clamping improved scores in the fi ne-motor and social domains at 4 years of age, especially in boys.The editorial by Rabe et al discusses the implications of this intervention for improving global infant health.
Hepatic toxicity from disinfectant abuse
Authors: J. M. Morse
Journal: JAMA (1984)

HEPATIC decompensation in abstaining alcoholic patients with cirrhosis is generally due to gastrointestinal tract bleeding, acute infection, hypotensive episode, or electrolyte imbalance. These precipitating factors are easily identified by careful evaluation. We recently cared for a patient with alcoholic cirrhosis who assured us that he was abstaining, but was drinking spray disinfectant (Lysol) containing 79% ethyl alcohol (158 proof). We believe that the alcohol contained in the disinfectant led to his hepatic decompensation. <h3>Report of a Case</h3> A 48-year-old man was admitted to the hospital on Nov 25, 1982, with recent onset of jaundice and ascites. He had a 20-year history of alcohol abuse, with no previous episodes of hepatic decompensation, and was receiving no medications. The patient specifically denied ingestion of beer, wine, or liquor over the three-year period prior to admission. On detailed questioning, however, he admitted that for the past three years, he had ingested the contents of
Fenfluramine.
Journal: BMJ (1967)

With the help of expert contributors we publish below notes on a selection of drugs in current use.Fenfluramine is an appetite depressant recently marketed in this country by Selpharm Laboratories Ltd. under the name Ponderax.It is not subject to the Drugs (Prevention of Misuse) Act, 1964. Chemistry and PharmacologyFenfluramine (trifluoromethyl-3 phenyl-1 ethylamino-2- propane hydrochloride) has been shown in animal studies effec- tively to reduce food intake.'Fenfluramine is not metabolized to amphetamine by animals or man but is present in the blood and urine partly unchanged and as nor-fenfluramine.2It is excreted slowly, which may account for its prolonged anorectic
Combination of Proteasome Inhibitors Bortezomib and NPI-0052 Trigger In Vivo Synergistic Cytotoxicity in Multiple Myeloma.
Authors: Dharminder Chauhan, Ajita Singh, Mohan Brahmandam, Klaus Podar, Teru Hideshima, Robert Schlossman, Paul Richardson, Nikhil Munshi, Michael Palladino, Kenneth C. Anderson
Journal: Blood (2007)