tbuckley/cabot-search huggingface dataset:
Ambivalence
Authors: Nancy L. Greengold
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intracardiac Rupture of Hydatid Cysts of the Heart
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VIVISECTION IN CONGRESS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Gloucester Small-pox Epidemic: The Criticisms of Mr. T Bayley, M.P.
Journal: BMJ (1898)

mRBr 703 of the Registrar-General for the island and are for the official year ended March 31st, 1897.They do not of course cover the mortality during the summer and autumn of 1897.In an article in the News Letter, published in Kingston on January 27th, we find it stated that " the death-rate for the city for the month of December, 1893, was 24.7 per I,ooo, while the death-rate for December, 1897, reached the very serious proportion of 38.I per i,ooo."The same journal, comparing the averages of successive years arrives at the conclusion that " the average death-rate for the twelve months of I893 was 24.3.In 1894 the average death-rate was 26.4; in 1895, 28.5; in I896, 29.3, and in 1897, 30.2."The inference our contemporary seems to draw from these rates is that the new system of sewerage is at the bottom of the increased mortality, and that it should be abandoned in favour of some other.We offer no opinion upon the rival merits of the several methods.We think Kingston, having deliberately adopted a well-considered scheme, would be foolish to attempt an exchange of horses in crossing the stream.We note also that in Kingston itself the actual number of deaths in the official year ended March 31st, I897, was fewer than in the year preceding it.We take the figures from Table H of the Registrar-General of the island: Deaths in Kingston, 1895-96, certified 1,155, not medi- cally certified 251; total I,406, or including Port Royal 1,453; I896-97, certified 1,046, not certified 332; total 1,378, or with Port Royal I,420, a decrease of 33 deaths in the whole parish, and as the births exceeded the deaths by some two-fifths the death-rate must have been lower in the last official year than in that which preceded it.If the apparently increased rate in the calendar year be actually as calculated by our contem- porary the increase must have occurred in the nine later months of 1897, including the period of the visitation of yellow fever.Although we are accepting the official declaration of freedom from this disease as correct, it is only fair to say that from advices received from two separate and both reliable sources we know that cases of the disease existed in the island during the month of January.
Military Medicine, Washington
Journal: JAMA (1964)

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Massachusetts Medical Society
Authors: Bruce R. Bistrian, George L. Blackburn, Donald M. Berwick, George F. Cahill, Mary Ellen Collins, Garry F. Fitzpatrick, Richard J. Grand, Baltej S. Maini, Thomas F. O'Donnell, Nevin S. Scrimshaw, Harrison D. Willcutts, Charles S. Davidson
Journal: New England Journal of Medicine (1981)

The Surgeon General's report for 1979, Healthy People,1 contains the following paragraph:Although evidence keeps mounting that certain food factors and current dietary habits may be linked with health problems as diverse as heart disease, tooth decay, obesity and some types of cancer, consumers often find it difficult to make informed choices about food.The Massachusetts Medical Society Committee on Nutrition believes that it is the responsibility of physicians, with the help of such allies as nutritionists, to advise the public on how to make intelligent choices about the food that they eat. Yet confusion seems to exist even . . .
The Limitations of Free Association
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
After Two Decades, Penn State Researchers May Be Near Perfecting Replacement Hearts and Lungs
Authors: Marsha F. Goldsmith
Journal: JAMA (1993)

KIDS ARE getting artificial hearts at the Milton S. Hershey Medical Center, Hershey, Pa. The baby goats are just the right size for testing electric pediatric ventricular assist pumps—miniature versions of the totally implantable wireless devices for adults that have been under development in calves there for several years. "We're at the point now where we can approach the Food and Drug Administration with a proposal to do a larger series of animals, because we've pretty much worked out the 'bugs' in this little device," says William S. Pierce, MD, professor of surgery and chief of the Division of Cardiothoracic Surgery, Pennsylvania State University College of Medicine, also in Hershey. The pediatric pumps, which have a 15-cm<sup>3</sup>stroke volume and could be used on an infant weighing 2 or 3 kg, are envisioned as supporting children with congenital heart defects prior to or during recovery from surgery. They are
Resource Utilization and Costs of Care in the Diabetes Control and Complications Trial
Journal: Diabetes Care (1995)

OBJECTIVE To describe in detail the resources used and costs incurred in the clinical management of patients with insulin-dependent diabetes mellitus (IDDM) in the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS The resources used for intensive and conventional therapy and to deal with the side effects of therapy were assessed at each of the 29 DCCT clinics and summarized. Unit costs were derived from the DCCT, manufacturers, and Medicare and chosen to reflect what an item would cost to a single-payer national health system. Costs were calculated as the product of resources used and unit costs. The costs of the research component of the DCCT were not included. RESULTS In the DCCT, the annual cost of intensive therapy ($4,000 and $5,800/year for multiple daily injections and continuous subcutaneous insulin infusion, respectively) was ∼ three times the cost of conventional therapy ($1,700/year). A large portion of the difference in cost was related to the greater frequency of outpatient visits and the greater resources used in self-care. CONCLUSIONS DCCT intensive therapy is more expensive than conventional therapy, but it offers the hope of cost savings as a result of averted complications.
Abstracts: Part II
Authors: F Lirussi, F Monica, A Beccarello, L Bortolato, C Triches, C Paleari, G Crepaldi, L Okolicsanyi, W Johanns, N Gniffke, C Jakobeit, L Greiner, C Tobis, M Pennazio, A Arrigoni, St Riedl, A Tandara, U Hinz, P Moller2, H Bodenmuller4, H Buhr, A Faissner, A Pilotto, M Franceschi, G Leandro, R Fabrello, L Bozzola, F Di Mario, V Meli, G Valerio
Journal: Gut (1995)

4th UEGWBerlin 1995 of an economical evaluation of endoscopic techniques.The aim of the study is to estimate costs of gastrointestinal endoscopic techniques in a unit as- sumed to perform 1) all the diagnostic and therapeutic procedures as well as visits, liver biopsies, ultrasonography, 2) more than 6000 procedures/year (II level endoscopic unit).The model for costs estimation took into account the following: 1) depreciation of instruments (videoenteroscopes, automatic washing machines, computers and so on) 2) cost of disposable and consum- able stores (i.e.detergents and disinfectants, gloves, drugs and so on) and repairs 3) medical, nursing and secretarial staff salaries.Building costs and the overhead charges (telephone, water, electric power) were not considered.A "weight" was given to each procedure according to the time required to perform it (i.e.colonoscopy-TC = 1, oesophagogastroduodenoscopy-EGD = 0.5, sigmoidoscopy-RS = 0.6, biopsy-BIO = 0.1, polypectomy-POLIP = 0.4).The number of procedures after which the instrument needs to be replaced was extabilished according to past experience of our unit.Cost calculation was based on 1993 activity.Costs in U.S.dollars are reported in table: Costs EGD CT RS BIO POLIP Staff 53 (71%) 107 (80%) 64 (77%) 10 (72%) 53 (74%) Depreciation 16 (22%) 22 (16%) 14 (17%) 0.8 (6%) 4 (6%) Disposables 5 (7%) 5 (4%) 5 (6%) 3 (22%) 15 (20%) Total (US dollars) 74 134 83 13.8 72In spite of the widespread use of expensive instruments, staff salaries account for the biggest percentage of costs.Costs were found to be compa- rable with those reported in European studies and lower than those found in the USA.Cost-benefit analysis of different diagnostic and therapeutic proce- dures must therefore take into account different local situations.
Poster Session 4: Therapeutics: Preclinical and Early Clinical Development
Journal: Hepatology (2015)

1305ANASH, 25 HC).The data are presented as median (Q1, Q3) for non-normal and mean (SD) for normal continuous variables.Groups were compared using Wilcoxon rank-sum tests and t-tests.Spearman correlation coefficients were used to examine association between variables.Results: NAFLD patients were older than HC and had significantly higher BMI, liver enzymes (AST, ALT), insulin resistance (HOMA-IR), hemoglobin A1c, and blood triglycerides (p<0.05).Fecal choline was higher in NAFLD vs HC: 16.6 (8.9, 28.8) mM vs 9.4 (0, 17.9) mM (p=0.02), as well as fecal TMA: 22.7 (0, 28.2) mM vs 0 (0, 10.6) mM (p=0.02).Both parameters were also associated with increased BMI: fecal choline was correlated to BMI in HC and NAFLD (r=0.46 p=0.01 in HC and r=0.37 p=0.02 in NAFLD) and TMA was correlated to BMI in HC only (r=0.71, p<0.001).Serum choline levels were not different between the groups, but were negatively correlated with percent of steatosis within the HC (4 healthy patients were found to have mild signs of steatosis) and the NAFLD group: r=-0.53,p=0.03 and r=-0.40 p=0.2, respectively.Serum, fecal, and dietary choline were not correlated.Conclusions: These preliminarily results provide evidence that bacterial interference in choline metabolism is related to NAFLD.BMI might also play a role in this complex relationship.Further investigations, including serum TMA levels and the characterization of the intestinal microbiota are in progress and should clarify the relationship.
The third United States-Japan meeting on the Toxicological Characterization of Environmental Chemicals.
Authors: Y Kurokawa, T Damstra
Journal: Environmental Health Perspectives (1992)

This report summarizes the discussion of the Third U.S.-Japan Meeting on the Toxicological Characterization of Environmental Chemicals held under the auspices of the U.S.-Japan cooperative in research and development in science and technology. Recent data on the interrelationships between toxicity, cell proliferation, and carcinogenicity are presented.
NCCN NewsNational Blood Cancer Experts Provide Updates on CAR T-Cell Therapy, Leukemia, Lymphoma, and Myeloma; New NCCN Guidelines for Systemic Mastocytosis Now AvailableNCCN Summit Explores How Current Health Policies Help and/or Hinder the Coordination of High-Quality Cancer Care Delivery in the United StatesNCCN and Lilly Support Quality Improvements for Gastric Cancer CareNew Guidelines Provide Vital Information for Women Diagnosed With the Most Common Type of Gynecologic Cancer
Journal: Journal of the National Comprehensive Cancer Network (2018)
Two Maternal Proteins May Protect Mammalian Embryo From Immunologic Rejection During Early Pregnancy
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Concentration-Dependent Inhibition of Development of GGT Positive Foci in Rat Liver by the Environmental Contaminant Di(2-Ethylhexyl) Phthalate
Authors: A. B. DeAngelo, A. E. Queral, C. T. Garrett
Journal: Environmental Health Perspectives (1985)

The ability of di(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer and environmental contaminant, to suppress development of putative preneoplastic lesions in rat liver was evaluated. gamma-Glutamyl transpeptidase-positive (GGT+) foci were initiated in the livers of Sprague-Dawley male rats with a single dose of diethylnitrosamine (DEN) following partial hepatectomy. Promotion of foci was commenced by feeding a choline-deficient diet (CD). A group of control rats was fed a choline-supplemented diet (CS). The ability of DEHP to suppress the emergence of GGT+ foci was evaluated by feeding additional groups of rats the CD diet containing either 0.1%, 0.5%, 1.0% or 2.0% DEHP. The CD diet promoted the number of GGT+ foci above levels in control livers. Inclusion of the plasticizer to the levels of 0.5%, 1.0% and 2.0% in the CD diet effectively inhibited the appearance of the foci. However, DEHP was unable to inhibit the promoting effect of the CD diet at a concentration of 0.1%. DEHP's ability to block development of GGT+ foci correlated with its ability to increase liver weight and to induce carnitine acetyltransferase (EC 2.3.1.7), a marker of peroxisome proliferation.
Abstract 1910: Regulation of ovarian tumor microenvironment dynamics by compressive stress
Authors: Marwa Asem, Allison Young Young, Alejandro ClaureDeLaZerda, Matthew Ravosa, Sharon Stack
Journal: Cancer Research (2019)

Abstract Ovarian cancer (OvCa) is the most fatal gynecologic malignancy and the fifth leading cause of overall cancer death among American women with a low (27%) 5-year survival rate, as 75% of women are diagnosed with disseminated intra-peritoneal (IP) metastasis. OvCa cells detach from the primary tumor and shed into the peritoneal cavity, adhere to the peritoneal mesothelial cell (MC) monolayer, intercalate within this layer, and invade into the submesothelial matrix, where they proliferate and form secondary lesions. More than one third of OvCa patients develop ascites that correlates with relapse and poor prognosis. The accumulated ascites can reach volumes up to 5 liters, causing a striking elevation in intraperitoneal pressure (IPP) from normally sub-atmospheric ~5 mmHg to as high as 27 mmHg, impacting the tumor microenvironment including host and tumor cells. The pressure created by accumulated ascites alters the force environment in the peritoneal cavity, causing strain and compressive forces on peritoneal structures. Yet, the mechanism through which ascites-induced IPP influences OvCa progression is poorly understood. The aim of this study is to understand how ascites-induced IPP promotes OvCa progression. To model the compressive force present in vivo due to accumulated tense ascites (~27 mmHg), we evaluated the effects of compressive force on primary human and murine MC monolayers and murine peritoneal explants using the Flexcell Compression System. Strikingly, compressed MC and peritoneal explants exhibited phenotypic alterations and formed abundant Tunneling Nanotubes (TNT), which are cell membrane extensions that modulate transfer of organelles between cells under stress. Furthermore, compression of OvCa cells adherent to murine peritoneal explants show intense formation of TNT between OvCa cells and peritoneal MC. Remarkably, TNT formed under compression displayed membrane distension and modulated the transfer of mitochondria from MC to OvCa cells. Moreover, collected peritoneal explants from OvCa murine model with intense ascites showed TNT formation and changes in the peritoneal sub-mesothelial collagen ultrastructure. This study reveals a novel response of OvCa cells and the tumor microenvironment to mechanical compression, uncovering a new mechanism by which OvCa metastatic success may be regulated. Note: This abstract was not presented at the meeting. Citation Format: Marwa Asem, Allison Young Young, Alejandro ClaureDeLaZerda, Matthew Ravosa, Sharon Stack. Regulation of ovarian tumor microenvironment dynamics by compressive stress [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1910.