tbuckley/cabot-search huggingface dataset:
Idiotype vaccine therapy (BiovaxID) in follicular lymphoma in first complete remission: Phase III clinical trial results
Authors: S. J. Schuster, S. S. Neelapu, B. L. Gause, F. M. Muggia, J. P. Gockerman, E. M. Sotomayor, J. N. Winter, C. R. Flowers, A. M. Stergiou, L. W. Kwak
Journal: Journal of Clinical Oncology (2009)

2 Background: In previous trials, tumor-specific purified idiotype (Id) protein conjugated to keyhole limpet hemocyanin (KLH) administered with granulocyte-monocyte colony-stimulating factor (GM-CSF) induced follicular lymphoma (FL)-specific immune responses and molecular remissions (Nat Med. 1999;5:1171–7). Methods: We conducted a prospective randomized double-blind placebo-controlled multicenter phase III study of patient-specific autologous tumor-derived Id vaccine in advanced stage previously untreated FL patients (pts) with a lymph node adequate for vaccine production (≥ 2cm). Pts achieving complete response (CR) or complete response unconfirmed (CRu) after chemotherapy (PACE: prednisone, doxorubicin, cyclophosphamide, etoposide) were stratified by International Prognostic Index risk group and randomized 2:1 to receive either vaccination with Id-KLH/GM-CSF or control (KLH/GM-CSF). The primary endpoint was disease free survival. Results: 234 pts were enrolled; 177 (76%) achieved CR/CRu and were randomized. Of 177 randomized pts, 117 maintained CR/CRu ≥ 6 mo per protocol requirement and then received at least one dose of vaccine, 55 relapsed before vaccination, 4 were vaccine manufacturing failures, and 1 violated protocol. Pts who received ≥ one vaccine dose constituted the modified intent-to-treat population for determination of efficacy. 76 pts received Id-KLH/GM-CSF and 41 pts received the control (KHL/GM-CSF). No serious adverse events were attributed to Id vaccination. At a median follow-up of 56.6 mo (range 12.6 –89.3 mo), median time to relapse after randomization for the Id-KLH/GM-CSF arm was 44.2 mo, versus 30.6 mo for the control arm (p = 0.045; HR = 1.6). Conclusions: Id vaccination after a chemotherapy-induced remission of ≥ 6 mo prolongs remission duration in pts with FL. Compared to other phase III Id vaccine trials, the positive outcome of this study may reflect application of Id vaccine in pts in CR/CRu or use of hybridomas to produce Id. Genomic and immune response analyses are planned on residual autologous tumor and blood samples. Additional studies of this patient-specific vaccine in FL pts pretreated with anti-CD20 antibody-containing chemotherapy are indicated. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Accentia Biopharmaceuticals, Biovest International Antigenics, Biogen Idec, Biovest International, Genentech Xeme Biopharma Biovest International
Beiträge zur Geschichte der Erkennung der Beriberi als Avitaminose.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survivorship care plan: Use of the "Oncology History" (OncHx) feature of the Epic electronic health record (EHR).
Authors: Kelly Bugos, Pooja Mishra, Mary Bruels, Ginna Laport, Blake Herring, Katrina Pose, Charles E. Williamson, Douglas W Blayney
Journal: Journal of Clinical Oncology (2014)

e20609 Background: Survivorship care plans, including a cancer treatment summary, are a standard of cancer survivorship care. At the Stanford Cancer Institute (SCI) OncHx, a Beacon module in Epic version 2012, became available May 2, 2013. The OncHx, linked to the problem list and visible to all SCI users, can be inserted in all encounter documentation and provides a chronological treatment summary. Events are categorized as: diagnosis, surgery, chemotherapy, radiation, blood and marrow transplant, anti-hormone therapy, disease status, procedures, hospital admissions and adverse reactions; each with associated dates and 256 character descriptions. Each event is auto-sorted by date. We measured OncHx use at SCI between 5/2/2013 and 12/31/2013. Methods: Our cohort was unique patients with a cancer diagnosis in the problem list and >1 visit to SCI during the analytic period. Cohort patients with >1 event recorded in OncHx at analytic period end were counted as having a populated OncHx. Results: 528 (6.8%) of 7,743 cancer patients treated at SCI during the first seven months of use had a populated OncHx associated with a cancer diagnosis in the problem list. Conclusions: The OncHx contains an organized, date-ordered and abbreviated treatment summary and is useful in generation of the Survivorship Care Plan. Initial adoption by SCI physicians and advanced practice providers has been slow. Use increased after more providers were given edit privileges. Future plans include providing non-Beacon users like surgeons with edit access, incorporation of OncHx events into provider workflow and measurement of adherence. We plan to display the OncHx on our patient portal, to engage patients in its creation and accuracy improvement. We will advocate for auto-population of events in future Epic versions.
Exercise May Benefit Many Persons With Asthma
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Review of Published Studies on Gut Penetration by Ingested Asbestos Fibers
Authors: Philip M. Cook
Journal: Environmental Health Perspectives (1983)

During the 1970s, potential health risks associated with exposure to asbestos in drinking water became a national concern. One of the key questions that arose from debate over whether ingestion of mineral fibers could result in increased gastrointestinal cancer risk was whether fibers can penetrate the gastrointestinal mucosa and thus have some chance of residing in tissue. It is likely that such movement of a large number of fibers is a necessary precursor for carcinogenesis following ingestion of asbestos. Studies of the potential for fiber accumulation in tissues and body fluids following introduction of asbestos to the alimentary canal have provided seemingly contradictory observations. This review, which places particular emphasis on the impact of experimental and analytical limitations on the evidential strengths of each study, indicates the likelihood that a very small fraction of ingested microscopic asbestos fibers penetrates the gastrointestinal mucosa. A reliable estimate of the magnitude of long-term fiber retention in tissues as a consequence of chronic human ingestion of asbestos cannot be made at this time.
Manuel élémentaire de puériculture.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply:
Authors: Inge Mannaerts, Leo van Grunsven
Journal: Hepatology (2010)

We thank Ikura et al. for their interest in our recently published article1 on the inhibitory effect of valproic acid (VPA) on hepatic stellate cell activation and consequent liver fibrosis in a chronically injured mouse liver. We fully agree with their opinion that prudence concerning the use of VPA in a clinical context is required. Their concern that VPA leads to adverse side effects was addressed in all treated mice by histological examination, but no obvious steatosis was observed. In addition, serum aminotransferase levels were not influenced by VPA treatment, and this suggests no direct hepatotoxic effect during these relatively short treatments in mice, as described earlier by Xia et al.2 We certainly do not suggest the immediate use of VPA as a therapeutic option for liver fibrosis. The use of VPA in the CCl4-induced mouse model of fibrosis has enabled us to demonstrate that class I histone deacetylases (HDACs) are involved in the activation of hepatic stellate cells. Our article is the first step toward the identification of HDAC-containing repressor complexes that govern this activation process in hepatic stellate cells. Because of their beneficial effects in several hematological and solid malignancies, several HDAC inhibitors are currently being evaluated in clinical trials.3 Those inhibitors that do not show adverse hepatic side effects could be tested for their capacity to inhibit liver fibrosis. Further research is most certainly needed to obtain reliable and specific delivery of HDAC inhibitors to hepatic stellate cells. A very promising approach using vitamin A–coupled liposomes was recently proposed.4 Inge Mannaerts M.S.*, Leo van Grunsven Ph.D.*, * Liver Cell Biology Lab, Department of Cell Biology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.
Plasma catecholamines in patients with presinusoidal portal hypertension: Comparison with cirrhotic patients and nonportal hypertensive subjects
Authors: C Gaudin
Journal: Hepatology (1991)

During a hemodynamic study, plasma catecholamine concentrations were measured in the pulmonary artery and in the hepatic vein in 18 presinusoidal portal hypertensive patients. Results were compared with those in 15 nonportal hypertensive subjects and in 24 cirrhotic patients in good condition (grade A, according to Pugh's classification). Plasma norepinephrine concentrations in the pulmonary artery or in the hepatic vein were not significantly different between nonportal hypertensive subjects (mean ± S.E.M.: 271 ± 36 and 83 ± 11 pg/ml, respectively) and presinusoidal portal hypertensive patients (273 ± 33 and 84 ± 11 pg/ml, respectively). These concentrations were, however, elevated in cirrhotic patients (408 ± 47 and 256 ± 45 pg/ml, p < 0.05 in comparison with the two other groups). These differences suggest that increased sympathetic nervous activity in cirrhosis is associated with the presence of liver disease or increase in sinusoidal pressure. Differences in plasma epinephrine concentrations were not significant among the three groups of patients. However, the existence of a significant correlation between pulmonary artery plasma epinephrine concentration and cardiac index (r2 = 0.46, p < 0.01) in patients with presinusoidal portal hypertension suggests that the adrenal medulla could play a role in the pathophysiology of the hyperkinetic syndrome of these patients. (HEPATOLOGY 1991;13:913–916.)
Abstract 3944: Converged Signaling of β-Catenin and Notch Induces Differentiation of Arterial Endothelial Cells from VEGFR2+ Vascular Progenitors
Authors: Kohei Yamamizu, Jun K Yamashita
Journal: Circulation (2008)

We have been investigating molecular mechanisms of vascular development and diversification using embryonic stem (ES) cells. Previously, we established an ES cell differentiation system that reproduces early vascular development using vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2)-positive cells as common vascular progenitors (Nature, 2000). Endothelial cells (ECs) were induced from VEGFR2 + progenitor cells with VEGF. VEGF alone mainly induced venous ECs, which are negative for arterial EC markers, ephrinB2 and CXCR4. Interestingly, addition of 8bromo-cAMP with VEGF activated Notch signaling in ECs and substantially induced arterial ECs. Nevertheless, activation of Notch using notch intracellular domain (NICD)-estrogen receptor fusion protein failed to induce arterial ECs (Arterioscler Thromb Vasc Biol, 2006). These results indicate that Notch activation was not sufficient to induce arterial ECs from vascular progenitors. Then we further investigated the downstream of cAMP, which would suffice signals for constructive induction of arterial ECs. We found that phosphatidylinositol-3 kinase (PI3K) inhibitor, LY294002, completely inhibited cAMP-induced arterial EC differentiation as well as Notch activation. GSK3β inhibitor, Bio, partially reversed the inhibitory effects of LY294002. Whereas activation of β-catenin signaling alone using Doxycycline-induced constitutive active form of β-catenin expression showed only a weak effect on arterial EC induction, simultaneous activation of β-catenin and Notch signaling completely restored arterial EC induction even in the absence of cAMP. Thus, cAMP-PI3K-GSK3β-β-catenin pathway plays a critical role in arterial EC differentiation. Furthermore, chromatin immunoprecipitation assay on the two RBP-J binding sites of mouse EphrinB2 revealed that RBP-J, NICD, and β-catenin formed a protein complex on these two sites only in arterial ECs, but not in venous ECs. These findings suggest that Notch and β-catenin signaling converged to form a novel arterial EC-specific protein complex to induce arterial ECs. This study would provide novel understandings of cellular and molecular mechanisms for arterial-venous specification and novel molecular targets for drug discovery.
Lentiviral vectors pseudotyped with minimal filovirus envelopes increased gene transfer in murine lung
Authors: M Fe Medina
Journal: Molecular Therapy (2003)

A human immunodeficiency virus (HIV)-based vector pseudotyped with the Ebola Zaire (EboZ) viral envelope glycoprotein (GP) was recently shown to transduce murine airway epithelia cells in vivo. In this study, the vector was further redesigned to improve gene transfer and also to increase safety. We used mutant EboZ envelopes for pseudotyping, which resulted in higher titers and increased transduction of airway cells in vivo compared to vectors pseudotyped with wild-type EboZ GP. As these envelopes lack regions associated with toxicity of the wild-type EboZ GP, they should also be safer to use for pseudotyping of lentiviral vectors. In addition, lentiviral vectors were created based on feline immunodeficiency virus and shown to have similar efficiency of transduction compared to HIV-based vectors. The creation of lentiviral vectors with highly engineered EboZ envelopes improved the performance of the system and should also increase its safety since only minimal regions of the EboZ envelope, which lack the toxic domain, are used.
Transmission of Primary and Secondary Syphilis by Oral Sex—Chicago, Illinois, 1998-2002
Journal: JAMA (2004)

During 1998-2002, the STD/HIV Prevention and Care Program of the Chicago Department of Public Health (CDPH) recorded 1,582 cases of primary and secondary (P&S) syphilis, the most of any U.S. city. Although case numbers and overall rates remained stable in Chicago during this period, patterns of transmission changed substantially. Throughout most of the 1990s, P&S syphilis was reported almost exclusively among heterosexuals. During 1998-2000, however, men who have sex with men (MSM) accounted for approximately 15% of Chicago's P&S syphilis morbidity. Since 2001, MSM have accounted for nearly 60% of patients with P&S syphilis. During 2000-2002, CDPH conducted interviews with persons with syphilis; some MSM reported they had engaged in only oral sex and were surprised to have acquired syphilis. In response, CDPH began collecting information on oral sex from persons with syphilis. To assess the role of oral sex in the transmission of P&S syphilis in Chicago, CDPH analyzed surveillance data and interview responses. This report summarizes the results of these analyses, which suggested that a substantial proportion (13.7%) of syphilis cases were attributed to oral sex, particularly among MSM. Persons who are not in a long-term monogamous relationship and who engage in oral sex should use barrier protection (e.g., male condoms or other barrier methods) to reduce the risk for sexually transmitted disease (STD) transmission.
Obstructive Jaundice
Authors: ROBERT P. YATTO
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 February 1984Obstructive JaundiceROBERT P. YATTO, M.D., JEROME H. SIEGEL, M.D.ROBERT P. YATTO, M.D.Search for more papers by this author, JEROME H. SIEGEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-2-318_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Richter and coworkers (1) begin their analysis of diagnostic strategies in cholestasis by stating, "A thorough evaluation of patients with suspected obstructive or cholestatic jaundice is needed to select appropriate treatment." Although the author's analysis of the various imaging techniques available is admirable, advances in interventional radiology and endoscopy have made appropriate treatment of cholestasis an integral part of the diagnostic process (2). Biliary decompression techniques used as adjuncts to direct cholangiography eliminate the barriers between surgical and medical jaundice, and must therefore be incorporated into the approach to the jaundiced patient (3).The value of biliary...References1. RICHTERSILVERSTEINSCHAPIRO JMR. Suspected obstructive jaundice: a decision analysis of diagnostic strategies. Ann Intern Med. 1983;99:46-51. LinkGoogle Scholar2. FERRUCCIADSONMUELLER JMP. Advances in the radiology of jaundice: a symposium and review. AJR. 1983;141:1-20. CrossrefMedlineGoogle Scholar3. SIEGELYATTO JR. Approach to cholestasis—an update. Arch Intern Med. 1982:142:1877-9. CrossrefMedlineGoogle Scholar4. NAKAYAMAIKEDAOKUDA TAK. Percutaneous transhepatic drainage of the biliary tract. Gastroenterology. 1978:74:554-9. CrossrefMedlineGoogle Scholar5. KOZAREKSANOWSKI RR. Nonsurgical management of extrahepatic obstructive jaundice. Ann Intern Med. 1982;96:743-5. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1984Volume 100, Issue 2Page: 318-318KeywordsEndoscopyImaging techniquesInterventional radiology Issue Published: 1 February 1984 PDF downloadLoading ...
Serological Diagnosis of Human Immunodeficiency Virus Infection by Western Blot Testing
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Total audit of preventive practices.
Journal: BMJ (1990)

the 35 who had moved into it (excluding the six children who had moved away or had no records).Doctors who are enthusiastic immunisers in practices with a high turnover of children therefore have to work exceptionally hard, as immunised children who move away tend to be replaced by those who have not been immunised.Un- fortunately, not even enthusiasts can give preschool boosters to children who have not completed the primary course.The practice's overall uptake of the preschool booster was disappointing at 68%, well below that of the primary course, which then averaged 85% across the new contract's three immunisation groups.The uptake has since been improved to 77% and can no doubt be improved further.For many practices, however, a target of 90% seems even more unreasonable for the preschool booster than for the primary course.