tbuckley/cabot-search huggingface dataset:
Does the timing of adjuvant chemotherapy for gastric cancer influence patient outcome?
Authors: Yong Won Choi, Seok Yun Kang, Mi Sun Ahn, Hyun Woo Lee, Jin-Hyuk Choi
Journal: Journal of Clinical Oncology (2015)

e15109 Background: Although adjuvant chemotherapy is currently established as standard treatment in stage II/III gastric cancer, there is no report about the optimal timing of the initiation of chemotherapy. We investigated the effect of the interval between surgery and the start of chemotherapy on patient outcome. Methods: A retrospective review was conducted of 410 patients who underwent 5-fluorouracil/mitomycin-C/polysaccharide-K adjuvant chemotherapy for stage IIA-IIIC gastric cancer after curative resection. Overall survival (OS) was compared among patients grouped by time from surgery to start of adjuvant chemotherapy. Results: The median time from surgery to chemotherapy was 21 days (7-80 days). Seventy-seven patients (18.8%) began adjuvant chemotherapy ≥ 28 days after surgery. The median follow-up duration was 150 months (97-195 months) for the survivors. There was no significant difference in 10-year OS between the patients who started chemotherapy < 21days after surgery and those who initiated it later (57.3% vs. 51.4%; p= 0.409). However, commencing chemotherapy ≥ 28 days after surgery was associated with inferior 10-year OS compared with earlier initiation (38.8% vs. 57.5%; p= 0.003), with a significant correlation in stage III (p< 0.0001) but not in stage II (p= 0.326). Furthermore, initiation of adjuvant chemotherapy ≥ 28 days after surgery was an independent prognostic factor of poor OS (p= 0.008), along with old age, large tumor size, Borrmann type IV, and advanced stages. Conclusions: It does not seem to be necessary to initiate adjuvant chemotherapy too early after gastric cancer surgery. However, it is desirable to start treatment within 4 weeks after surgery if patients have fully recovered, especially in those with stage III.
Wilms' tumor metastatic to the orbit
Authors: J. D. Fratkin
Journal: JAMA (1977)

In a 2 1/2-year-old boy, a proptotic right lower lid developed one year after a primary abdominal mass proved to be Wilms' tumor. An orbital abscess or fungal infection was considered because the child was receiving chemotherapy. However, echography demonstrated a firm orbital mass, delineated its dimensions, and showed destruction of the orbital floor. The biopsy specimen showed metastatic tumor cells. Like neuroblastoma and certain hematologic and reticuloendothelial malignant neoplasms, Wilms' tumor may secondarily invade the ocular adnexa. (<i>JAMA</i>238:1841-1842, 1977)
ETIOLOGY OF HAY-FEVER IN ARIZONA AND THE SOUTHWEST
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Who Decides the Law of the Land?
Authors: Charles W. Schmidt
Journal: Environmental Health Perspectives (1998)

A cornerstone of American-Indian cultures is a deep sense of interconnectedness with the natural environment. To preserve this sense of interconnectedness on tribal lands, many American Indians believe that sovereignty over environmental affairs on tribal lands is essential. But a number of shortcomings have historically and continually weakened tribal authority, and years of federal neglect have left most tribes unprepared to deal with their environmental problems.
Evolution of hepatitis C virus genotype 1a vs 1b distribution reflects profound changes in HCV epidemiology in Germany - analysis of 17,093 patients from five consecutive registries including the German hepatitis C-registry (DHC-R)
Authors: Karl-Georg Simon, Yvonne Serfert, Peter Buggisch, Stefan Mauss, Klaus Boeker, Hartwig Klinker, Tobias Müller, Uta Merle, Dietrich Hüppe, Michael P. Manns, Heiner Wedemeyer, German Hepatitis C-Registry
Journal: Journal of Hepatology (2020)
BREAST-MILK JAUNDICE
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular Neurobiology and Genetics of Circadian Rhythms in Mammals
Authors: J. Takahashi
Journal: Annual Review of Neuroscience (1995)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
261P Efficacy of chemotherapy in patients with unresectable or metastatic pancreatic acinar cell carcinoma: Potentially improved efficacy with oxaliplatin-containing regimen
Authors: J. Cheon, C. Yoo, B. Kim, K.-P. Kim, J.-L. Lee, T.W. Kim, B.-Y. Ryoo, H.-M. Chang
Journal: Annals of Oncology (2016)
Blood Transfusion: Sale or Service
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early Use of Circulating Blood Volume, Weights and Normal Diet in Acute Renal Failure
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phenothiazine intoxication in children. A report of three cases
Authors: J. D. Corless
Journal: JAMA (1965)

THE NEUROLOGICAL syndromes due to phenothiazines, consisting of dystonia, akathisia, and a parkinsonian state, have been frequently described.<sup>1-4</sup>Symptoms of phenothiazine toxicity are known to be more marked in infants and young adults, and they also occur with more frequency in patients in a toxic condition and in dehydrated and febrile patients.<sup>3</sup>There is little mention in the literature of reactions which produce spasticity and pathological reflexes. One such case, reported by Swaiman,<sup>5</sup>concerns a widely used and relatively safe phenothiazine, promethazine hydrochloride, which caused marked central-nervous-system depression, hyperreflexia and Babinski's sign on both sides in a dehydrated child. We have seen similar patients whom we feel developed such neurological symptoms and signs as a result of a reaction to phenothiazines. <h3>Report of Cases</h3><h3>Case 1.—</h3> An 8-year-old white boy was admitted because of two days of lethargy, anorexia, and vomiting, and several hours of irrational behavior,
Studies on induced influenza in man. I. Double-blind studies designed to assess prophylactic efficacy of amantadine hydrochloride against a2/Rockville/1/65 strain
Authors: Y. Togo
Journal: JAMA (1968)

Prophylactic administration of amantadine hydrochloride diminished significantly the occurrence and severity of experimentally induced Asian influenza illness in double-blind studies conducted in 58 volunteers. No difference in infection (seroconversion) rate was observed but serum neutralizing antibody titers were significantly lower in men receiving amantadine compared to those of control subjects. Reduction in the severity and occurrence of disease and lower postchallenge antibody level are based probably on indirect inhibition of virus multiplication and consequent diminution of antigenic stimulation.
“An official European Respiratory Society statement: pulmonary haemodynamics during exercise.” Gabor Kovacs, Philippe Herve, Joan Albert Barbera, Ari Chaouat, Denis Chemla, Robin Condliffe, Gilles Garcia, Ekkehard Grünig, Luke Howard, Marc Humbert, Edmund Lau, Pierantonio Laveneziana, Gregory D. Lewis, Robert Naeije, Andrew Peacock, Stephan Rosenkranz, Rajeev Saggar, Silvia Ulrich, Dario Vizza, Anton Vonk Noordegraaf and Horst Olschewski.<i>Eur Respir J</i>2017; 50: 1700578.
Journal: European Respiratory Journal (2018)
Heart surgery
Authors: R. S. Blacher
Journal: JAMA (1979)

THERE are few medical procedures more fraught with anxiety for the patient than surgery on the human heart. Because the heart occupies a unique position in the psychic life of man, cardiac surgery becomes an experience for the patient that is qualitatively different from any other surgery. The heart is not only the central organ of the body and historically the seat of emotions, it is the only organ that functions in a dramatic on-off mode. If it beats, one lives; if it stops its beat, one dies. This definition of death as equated with cessation of heartbeat is the prevalent one in our society, despite the more scientific resort to EEG findings. The heart, not the brain, is seen as the indicator of life and death. <h3>Undergoing Surgery</h3> Thus, the patient undergoing cardiac surgery has a different emotional task than the patient dealing with surgery on any other organ.
CONCENTRATED FOOD AND ARMY RATIONS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Self-Management Education for Osteoarthritis
Authors: Halsted R. Holman, Kate Lorig
Journal: Annals of Internal Medicine (2006)

Letters18 April 2006Self-Management Education for OsteoarthritisHalsted R. Holman, MD and Kate Lorig, RN, DrPHHalsted R. Holman, MDFrom Stanford University, Stanford, CA 94305.Search for more papers by this author and Kate Lorig, RN, DrPHFrom Stanford University, Stanford, CA 94305.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-8-200604180-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Because patients with chronic disease must be their own principal caretakers, education of patients for this task is essential for good health care. In evaluating education programs, there can be differences in selection of programs and in methods used for meta-analysis. However, as in this case, no contribution is made to improving health care by grouping and evaluating together widely different education programs that are delivered in widely different ways by people with widely different skills. What is needed is to identify successful programs and their components and to analyze the ways those components act and interact. In ... Author, Article, and Disclosure InformationAffiliations: From Stanford University, Stanford, CA 94305.Disclosures: Grants received: H.R. Holman (National Institutes of Health, Robert Wood Johnson Foundation, American Lung Association). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: Chronic Disease Self-Management Programs for Older Adults Joshua Chodosh , Sally C. Morton , Walter Mojica , Margaret Maglione , Marika J. Suttorp , Lara Hilton , Shannon Rhodes , and Paul Shekelle Self-Management Education for Osteoarthritis Halsted R. Holman and Kate Lorig Self-Management Education for Osteoarthritis Joshua Chodosh , Sally C. Morton , Marika J. Suttorp , and Paul G. Shekelle Metrics Cited bySelf-Management Support and Communication from Nurse Care Managers Compared with Primary Care Physicians: A Focus Group Study of Patients with Chronic Musculoskeletal PainStepped Care for Affective Disorders and Musculoskeletal Pain (SCAMP) study 18 April 2006Volume 144, Issue 8Page: 618KeywordsConflicts of interestHealth careLongitudinal studiesLungsOsteoarthritis ePublished: 18 April 2006 Issue Published: 18 April 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 168: Resveratrol Translocates Gsk-3β To Mitochondria And Protects The Heart At Reperfusion By Targeting The Mitochondrial Permeability Transition Pore
Authors: Jinkun Xi, Huihua Wang, Guillaume Chanoit, Guang Cheng, Robert A Mueller, Edward A Norfleet, Zhelong Xu
Journal: Circulation (2007)

Although resveratrol has been demonstrated to be cardioprotective, the detailed cellular and molecular mechanisms that mediate the protection remain elusive. We aimed to determine if resveratrol protects the heart at reperfusion by modulating the mitochondrial permeability transition pore (mPTP) opening through glycogen synthase kinase 3β (GSK-3β). Resveratrol (10μM) given at reperfusion reduced infarct size (12.2 ± 2.5 % of risk zone vs. 37.9 ± 3.1 % of risk zone in control, n = 6) in isolated rat hearts subjected to 30 min regional ischemia followed by 2 h of reperfusion, an effect that was abrogated by the mPTP opener atractyloside (30.9 ± 8.1 % of risk zone), implying that resveratrol may protect the heart at reperfusion by modulating the mPTP opening. To define the signaling mechanism underlying the action of resveratrol, we determined GSK-3β activity by measuring its phosphorylation at Ser 9 . Resveratrol significantly enhanced GSK-3β phosphorylation upon reperfusion (225.2 ± 30.0 % of control at 5 min of reperfusion). Further experiments showed that resveratrol induces translocation of GSK-3β to mitochondria and translocated GSK-3β interacts with the mPTP component cyclophilin D but not VDAC (the voltage-dependent anion channel) or ANT (the adenine nucleotide translocator) in cardiac mitochondria. Taken together, these data suggest that resveratrol prevents myocardial reperfusion injury by targeting the mPTP opening via GSK-3β. Translocation of GSK-3β to mitochondria and its interaction with the mPTP component cyclophilin D may serve as an essential mechanism that mediates the protective effect of resveratrol on reperfusion injury.
THE ADJUSTMENT TO VARYING ATMOSPHERIC CONDITIONS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biomedical Ethics
Authors: LeRoy Walters
Journal: JAMA (1982)

In 1981 the human embryo and fetus were central figures in bioethical discussions. New diagnostic and therapeutic techniques made the human fetus seem more like a distinguishable patient, especially during the second and third trimesters of pregnancy. Within the legislative arena, the question of abortion was vigorously debated in hearings before the US Congress. Two distinct approaches to the abortion question emerged—one based on a proposed statute, the other based on a proposed constitutional amendment—and the issue of abortion seemed headed for a congressional showdown in 1982. At year's end the first successful birth in the United States following in vitro fertilization and embryo transfer was reported by a clinic in Norfolk, Va. <h3>The Fetus as Patient</h3> New techniques for prenatal diagnosis—for example, ultrasonography, amniocentesis, and fetoscopy—provide early information about the clinical status of the fetus to both prospective parents and physicians. This information then constitutes the basis for various
Kleine Sportkunde für Ärzte, Lehrer, Studierende der Medizin und der Leibesübungen.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal