tbuckley/cabot-search huggingface dataset:
Digitalis
Authors: Paul J. Hauptman, Ralph A. Kelly
Journal: Circulation (1999)

Abstract —Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified their use in his late 18th century monograph on the efficacy of the leaves of the common foxglove plant ( Digitalis purpurea ). Despite their widespread acceptance into medical practice in the ensuing 200 years, both the efficacy and the safety of this class of drugs continue to be a topic of debate. Moreover, despite the fact that the molecular target for the cardiac glycosides, the α-subunit of sarcolemmal Na + K + -ATPase (or sodium pump) found on most eukaryotic cell membranes, has been known for several decades, it remains controversial whether the sympatholytic or positive inotropic effects of these agents is the mechanism most relevant to relief of heart failure symptoms in humans with systolic ventricular dysfunction. Herein, we review the molecular and clinical pharmacology of this venerable class of drugs, as well as the manifestations of digitalis toxicity and their treatment. We also review in some detail recent clinical trials designed to examine the efficacy of these drugs in heart failure, with a focus on the Digoxin Investigation Group data set. Although, in our opinion, the data on balance warrant the continued use of these drugs for the treatment of symptoms of heart failure in patients already receiving contemporary multidrug therapy for this disease, the use of digitalis preparations will inevitably decline with the maturation of newer pharmacotherapies.
RAPID CURE FOR APPENDICITIS.
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Classification BASIC (BLI adenoma seraated international classification) pour caractérsation des polypes clorectaux avec le “blue light imaging”
Journal: Endoscopy (2018)

Améliorer la caractérisation des polypes coliques lors de coloscopie permettrait, si ces outils sont fiables, d'une part d'éviter la résection de polypes à faible risque évolutif (cout-efficacité), et d'autre part de déterminer pour les lésions avancées le risque d'envahissement sous muqueux profond afin de déterminer la meilleure stratégie thérapeutique. la chromoendoscopie électronique est un outil performant est des classification ont été développées essentiellement pour le NBI.
Risk factors for delirium in hospitalized elderly
Authors: J. D. Schor
Journal: JAMA (1992)

<h3>Objective.</h3> —To determine risk factors for delirium in elderly hospitalized patients. <h3>Design.</h3> —Cohort analytic study. Using a reliable and valid instrument for detection of delirium, we prospectively followed up a cohort of elderly patients admitted to an acute care hospital. Using standardized criteria, we collected risk factor data from patient medical records. <h3>Setting.</h3> —General medical and surgical wards of a tertiary-care hospital. <h3>Patients.</h3> —Patients (n=325) were 65 years of age or older, from either a geographically defined community or a long-term-care institution. We studied those patients (n = 291) not delirious on first evaluation. Fifty-seven patients or their families refused participation. <h3>Main Outcome Measures.</h3> —Incidence of delirium and risk factors calculated as adjusted odds ratios (ORs). <h3>Main Results.</h3> —Delirium developed in 91 patients. By stepwise logistic regression, the independent risk factors for in-hospital delirium included prior cognitive impairment (OR, 8.97; 95% confidence interval [Cl], 3.99 to 20.14), age over 80 years (OR, 5.22; 95% CI, 2.60 to 10.46), fracture on admission (OR, 6.57; 95% Cl, 2.23 to 19.33), symptomatic infection (OR, 2.96; 95% Cl, 1.42 to 6.15), and male sex (OR, 2.40; 95% CI, 1.19 to 4.84). Among medication groups, only neuroleptic use (OR, 4.48; 95% CI, 1.82 to 10.45) and narcotic use (OR, 2.54; 95% CI, 1.24 to 5.18) were independently associated with delirium. Anticholinergic use was not associated with delirium. <h3>Conclusions.</h3> —Delirium in hospitalized patients is most closely associated with factors already present on admission such as prior cognitive impairment, advanced age, and fracture. In the hospital, use of neuroleptics and narcotics and the presence of infection are less strongly associated with this syndrome. (<i>JAMA</i>. 1992;267:827-831)
THE RECTUM IN ULCERATIVE COLITIS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Missing Author Affiliation
Authors: Daniel Pan, Liqun Zhang, Anthony Pereira, Mandip Dhamoon
Journal: JAMA Neurology (2018)

Yael Hacohen, MD, DPhil; Yu Yi Wong, MD; Christian Lechner, MD; Maciej Jurynczyk, MD, PhD; Sukhvir Wright, MD, DPhil; Bahadir Konuskan, MD, PhD; Judith Kalser, MD; Anne Lise Poulat, MD; Helene Maurey, MD; Esther Ganelin-Cohen, MD; Evangeline Wassmer, MD; Chery Hemingway, MD, PhD; Rob Forsyth, MD, PhD; Eva Maria Hennes, MD; M. Isabel Leite, MD, PhD; Olga Ciccarelli, MD, PhD; Banu Anlar, MD, PhD; Rogier Hintzen, MD, PhD; Romain Marignier, MD, PhD; Jacqueline Palace, DM; Matthias Baumann, MD; Kevin Rostásy, MD; Rinze Neuteboom, MD, PhD; Kumaran Deiva, MD, PhD; Ming Lim, MD, PhD
Differenzial Diagnosis of Pancreatic Cancer from Normal Tissue Using Digital Imaging Processing and Pattern Recognition based on Support Vector Machine of EUS Images
Authors: Zhang MinMin, Yang Hua, Jin ZhenDong, Li ZhaoShen, Yu JianGuo, Cai ZheYuan
Journal: Endoscopy (2011)

Background: Endoscopic ultrasonography (EUS) can detect morphologic abnormalities of pancreatic cancer with high sensitivity, but with limited specificity. In the present study, we applied digital imaging processing (DIP) technique to EUS images of pancreas to develop a classification model for differenzial diagnosis of pancreatic cancer.
Distinct intrahepatic molecular signature between relapse and sustained remission of autoimmune hepatitis before initiation of immunosuppression withdrawal
Authors: Finn Derben, Bastian Engel, Johannes Hartl, Danny Jonigk, Geffers Robert, Ansgar Lohse, Michael P. Manns, Christoph Schramm, Elmar Jaeckel, Richard Taubert
Journal: Journal of Hepatology (2020)
'Caution: pets may be hazardous to your health'
Authors: W. T. Hubbert
Journal: JAMA (1984)

Today, we expect to find the label, "Warning: The Surgeon General Has Determined That Cigarette Smoking Is Dangerous to Your Health," on every cigarette package. We do not, however, place a similar label, "Caution: This Pet May Be a Hazard to Your Health," on every pet. Nevertheless, the risks are there for those who handle pets. In addition, there are diagnostic hazards for those who must deal with their associated illnesses. The articles appearing in this issue ofThe Journalbring several of these hazards to our attention. If we keep such hazards in mind, we can avoid them, thereby making the rewards from informed, responsible pet ownership even greater. Likewise, an adequate suspicion of these hazards often is critical to achieving the rewards of prompt, accurate diagnosis and effective therapy. The emotional and physical benefits derived from the human-animal bond are well recognized. The therapeutic value of the bond
Hearing Impairment for Speech
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
Authors: Robert W. Schrier, Wei Wang, Brian Poole, Amit Mitra
Journal: Journal of Clinical Investigation (2004)

During the preparation of this manuscript for publication, an error was introduced into the Results section, in the fourth sentence of the paragraph beginning with "The levels of the APP-derived soluble peptides Aβ40 and Aβ42 in brains of double-transgenic mice and APP [V717I] control animals at the age of 18 weeks were quantified by specific sandwich ELISAs."The correct sentence appears below.We regret this error.In line ADAM10-mo × APP [V717I] , Αβ40 and Aβ42 were reduced by 49% and 20%, and in line ADAM10-hi × APP [V717I] , by 39% and 29%, respectively.
Association between pathological and MRI findings in multiple sclerosis
Authors: Massimo Filippi, Wolfgang Brück, Declan Chard, Franz Fazekas, Jeroen J G Geurts, Christian Enzinger, Simon Hametner, Tanja Kuhlmann, Paolo Preziosa, Àlex Rovira, Klaus Schmierer, Christine Stadelmann, Maria A Rocca
Journal: The Lancet Neurology (2019)
Abstract 2178: Sonic Hedgehog In Adult Hypoxic Cerebellum
Authors: Giuseppe Straface, Andrea Flex, Federico Biscetti, Eleonora Gaetani, Giovanni Pecorini, Flavia Angelini, Paolo Pola, Roberto Pola
Journal: Circulation (2007)

Background: Cerebellar hypoxia is responsible for important aspects of cognitive deterioration and motor disturbances in neurological disorders, such as stroke, vascular dementia, and neurodegeneration. In the cerebellum, VEGF is significantly upregulated after hypoxia and is able to induce angiogenesis, reduce neuronal apoptosis, and regulate neuronal differentiation, proliferation, and migration. But, VEGF is not sufficient to provide neuroprotection. A crucial role is played by growth associated protein-43 (GAP43), for which important activities have been described. The purpose of this study was to investigate the role of the developmental Sonic hedgehog (Shh) signaling pathway in postnatal hypoxic cerebellum and its relationship with VEGF and GAP43 expression. Methods: We used adult C57BL/6J mice, ptc1-lacZ mice, and GAP43−/− mice for these experiments. Ptc1-lacZ mice carry a non-disruptive insertion of the lacZ gene under the control of the ptc1 promoter. Ptc1 is a downstream-transcriptional target of Shh and its upregulation indicates activation of the Shh pathway. Mice were exposed to systemic normobaric hypoxia (6%O 2 ) for 6 hours and the expression of Shh, Ptc1, VEGF, and GAP43 were investigated. Results: After exposure to hypoxia, Shh-positive staining was detected in Purkinje cells (PCs). The same cells were also lacZ(ptc1)-positive, indicating that PCs are both Shh-producing and -responding elements. Also the cells of the internal granular layer (IGL) were lacZ(ptc1)-positive, indicating that these cells are Shh-responsive. LacZ(ptc1)-positive IGL cells were also immunopositive for VEGF and GAP-43. We also found that ptc1 expression is lost in PCs of GAP43−/− mice, indicating that Shh requires GAP43 to activate its downstream target genes in PCs. Finally, when cultures enriched in granular cells were stimulated with Shh recombinant protein, GAP43 phosphorylation was increased. This effect was inhibited by Shh-inhibitor cyclopamine. Conclusions: This is the first time that hypoxia is reported to activate the Shh pathway in the adult. Our data suggest that the Shh pathway might be important for the cerebellar response to hypoxia, through interactions with VEGF and GAP43.
TRAVEL NOTES FROM SOUTH AMERICA.
Authors: NICHOLAS SENN
Journal: JAMA (1907)

<h3>III. *THE MEDICAL PROFESSION, MEDICAL SOCIETIES AND MEDICAL JOURNALS OF RIO DE JANEIRO.</h3> The South American physicians are men with excellent preliminary education, as a college degree is one of the requirements of entrance exacted by the medical schools, and during their six years of training as students of medicine these men acquire a good knowledge of their profession. After graduation, many of them spend a year or more as assistants in hospitals, where they become familiar with the practical work of their future careers. Some of them, after graduation or expiration of their hospital service, go to some of the larger medical centers in Europe, most frequently to Paris, in quest of more knowledge before they assume the responsibilities of an independent practice. On the whole, the physicians here occupy a much higher position in the esteem of the public than in our country. They are influential members of
Objectives of the Committee on Rehabilitation
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re: Niranjan J. Sathianathen, Badrinath R. Konety, Fernando Alarid-Escudero, Nathan Lawrentschuk, Damien M. Bolton, Karen M. Kuntz. Cost-effectiveness Analysis of Active Surveillance Strategies for Men with Low-risk Prostate Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.10.055
Authors: Diana A. Castillo-Jimenez, Herney A. García-Perdomo
Journal: European Urology (2019)
Abstract 209: Metastatic colonization in the perivascular niche: A mechanotransduction perspective
Authors: Ekrem Emrah Er, Maria Tello-Lafoz, Jing Hu, Morgan Huse, Joan Massagué
Journal: Cancer Research (2019)

Abstract Metastases are responsible for majority cancer related deaths. Disseminated tumor cells (DTCs) gain a diverse array of metastatic traits in order to adapt to and survive within different microenvironments, making them very difficult to therapeutically target. Remarkably, regardless of the secondary organ, DTCs survive and thrive in perivascular niches. Using xenograft and syngeneic models of metastasis in mouse, we found that upon extravasation, neuronal cell adhesion molecule L1 (L1CAM) expressed by DTCs engages the vascular basal lamina in order to amplify integrin β1 and integrin linked kinase (ILK) signaling in DTCs. ILK promotes actin polymerization for cell spreading and subsequent activation of mechanotransduction effector transcription factors YAP and MRTF. We found that activation of YAP and MRTF coincides with DTCs ability to dislodge resident pericytes from the perivascular niche and is an essential step in the metastatic colonization regardless of dormancy state. Therefore, these results provided us a unifying molecular mechanism that governs cancer progression from metastatic seeding to overt colonization. Ongoing studies will determine how mechanotransduction and pericyte-DTC interactions can be manipulated to prevent metastatic colonization by potentiating the immune response and exposing their biophysical vulnerabilities. Citation Format: Ekrem Emrah Er, Maria Tello-Lafoz, Jing Hu, Morgan Huse, Joan Massagué. Metastatic colonization in the perivascular niche: A mechanotransduction perspective [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 209.
Postoperative hypoxia in a woman with Down's syndrome: case progression
Authors: A K Siotia, A Chaudhuri, S I Muzulu, D Harling, R Muthusamy
Journal: BMJ (2005)

Last week (9 April, p 834) we presented the case of Miss Webb, who has Down's syndrome and had a sudden postoperative deterioration in her condition after a hysterectomy for menorrhagia. We invited readers to comment on the ethical issues around surgery and the possible cause and management of her postoperative hypoxia. ![][1]</img> View this table: Possible reasons for rise in male suicide rates in United … [1]: /embed/graphic-1.gif
Error in Figure
Authors: Shawn Rangel, Jonathan Hills-Dunlap
Journal: JAMA Pediatrics (2019)

In Reply We read with interest the comments submitted by Kohler et al in response to our analysis exploring the influence of sociodemographic factors on timing of asymptomatic umbilical hernia repair in children. 1 In their commentary, they propose that the disparities in care characterized in the analysis may be owing to practice variation arising from a lack of well-established consensus guidelines.While we agree that marked practice variation exists in the timing of umbilical hernia repair across children's hospitals, 2 we would disagree with the notion that a lack of (or compliance with) recommendations is inherently responsible for the observed disparities.Hierarchical regression was used in our analysis to control for hospital-level differences in timing of umbilical hernia repair when assessing potential risk factors.Following adjustment, marked disparities in the risk of early umbilical hernia repair remained for children with public insurance and lower income, and these trends were observed across most children's hospitals examined.These findings would suggest that disparities associated with disadvantaged sociodemographic backgrounds are not only pervasive but also independent from the broader practice variation that exists across children's hospitals.From a public health and intervention perspective, the increased risk of early umbilical hernia repair associated with sociodemographic factors should be considered a separate issue from that pertaining to broader practice variation.Strategies to address disparities should begin with outreach programs and multidisciplinary educational efforts targeting both high-risk families and the clinicians who predominantly serve these communities.Policy changes surrounding insurance coverage may also play an important role because differential reimbursement policy may inadvertently enable surgeons to perform earlier repairs on publicly insured children.Future efforts to reduce disparities, as well as the variation surrounding potentially unnecessary early repairs for all children, are needed to ensure that surgeons are providing equitable and optimal care to all children with this common condition.In this regard, we could not agree more with Kohler et al that establishing more formalized consensus guidelines are an important next step in addressing practice variation on a broader scale.
Hewat's Examination of the Urine and Other Clinical Side-Room Methods.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decreased anion gap associated with hypoalbuminemia and polyclonal gammopathy
Authors: A. A. Nanji
Journal: JAMA (1981)

Anion gaps were determined in 82 patients with hypoalbuminemia; 24 of these patients had a polyclonal increase in γ-globulin levels (designated group 5). The 58 patients without the polyclonal increase in γ-globulin levels were subdivided according to the origin of their serum albumin loss as follows: group 1, renal; group 2, gastrointestinal; group 3, skin; and group 4, malignant neoplasms. All groups had a statistically significant reduction in their mean anion gaps when compared with normal control subjects. The greatest decrease was when hypoalbuminemia was accompanied by a polyclonal increase in γ-globulin levels. Hypoalbuminemia with or without a polyclonal gammopathy is a cause of a low anion gap. No statistically significant correlation was found between the anion gaps and individual serum albumin concentrations. (<i>JAMA</i>1981;246:859-860)