tbuckley/cabot-search huggingface dataset:
Abstract 031: An Innovative Home Care Delivery Model Reduces The Rate Of Dropouts Found With Traditional Cardiac Rehabilitation
Authors: Hang Ding, Marlien Varnfield, Chi-Keung Lee, Johanna VanVeen, Desre Arnold, Anita Keightley, Darren Walters, Mohan Karunanithi
Journal: Circulation (2012)

Introduction: Despite recognized benefits of cardiac rehabilitation (CR), utilization of traditional centre based CR programs has been poor (16–19% of eligible patients) in Australia and USA. To address this issue, an innovative home care model (CAP), based on smart phone technologies, was developed by the Australian e-Health Research Centre and Queensland Health. The aims of this study were to assess perceived barriers of dropouts in traditional CR (TC) and observe the efficacy of the CAP in overcoming these barriers through a randomized control trial. Method: Following consent, 120 patients from the Metro North Health Services District, Queensland, were randomised to the CAP (n=60) and control, TC (n=60) CR groups. Dropout rates were observed between the two groups and their perceived barriers were analysed through questionnaires and categorized according to: 1) life demands (work and family commitments), 2) facilitating factors (difficulties in transportation and/or parking), 3) group preference (exercise in groups), 4) medical reasons (deterioration in health), 5) technical difficulties, 6) lack of motivation, 7) lack of need for CR (due to improvement in health) and 8) other reasons. The dropout rates were analysed by the two sided Fisher’s exact test in SPSSvs16. Results: Patients’ ages (Mean±SD) between the CAP (59±12 yrs) and TC (59±9 yrs) groups were similar. Dropouts for the TC were mainly due to Categories 1 and 2 (C1 TC =21.7%, C2 TC =21.7%); and they were reduced significantly (p&lt;0.05) for CAP (C1 CAP =5.0%, C2 CAP =3.3%). No significant difference was found for the remaining categories between the two groups. Category 7 was not responsible for any dropouts in either of the groups. Conclusion: The study demonstrates that both competing life demands and facilitating factors were the key barriers to patient dropouts from traditional CR programs, despite patients’ recognition of need to participate in the CR programs. The CAP was able to overcome these two barriers, and hence improve the rate of utilization of CR programs.
FOOD VALUE OF ALCOHOL.
Journal: JAMA (1899)

The recent statements of the public press concerning the findings of Professor Atwater, the Government food expert, regarding the nutritive value of alcohol, are worthy of a passing notice. While some authorities have disputed it, the consensus of scientific opinion has always been that a certain amount of alcohol could be consumed in the body. Professor Atwater's findings are different from those of others only in that he finds a little larger quantity can be disposed of than some other hygienic authorities. He does not say that it is a healthful food or that it can be safely taken in a quantity sufficient to have any large effect in keeping the vital mechanism going. While it may be to some extent a producer of energy, its action even in small quantities, on special portions of the organism, may be deleterious. The experiments of Aschaffenburg in Kræpelin's clinic are in point
Microvascular integrity contributes to the myocardial remodeling in pressure overload LV hypertrophy following aortic banding Peter Liu, Fayez Dawood, Wen-Hu Wen, Michael J. Sole, Jean L. Rouleau, Duncan J. Stewart. Heart &amp; Stroke/Richard Lewar Centre of Excellence, Toronto, ON, Canada
Journal: Journal of the American College of Cardiology (2001)
Atrial septostomy.
Authors: J. Hamill, D. Pickering, P. Sleight
Journal: BMJ (1968)

asthmatic patient's restlessness and irrational behaviour is due to his anoxaemia and hypercarbia and can be safely relieved only by adequate ventilation.So far as the actual management of status asthmaticus is concerned, I am again highly surprised to see so many experts putting such great accent on the use of corticosteroids without mention of the fundamental approach of hydration of the patient in status asthmaticus.This is im- perative if we are to encourage the thinning out and eventual expectoration of the dried- up secretions and mucous plugs.Undetected respiratory infections have been reported as one of the causes of death in bronchial asthma, and a high index of suspicion with prompt and adequate institution of an appropriate antibiotic therapy could save many lives.Finally, close follow-up of the clinical pic- ture as well as frequent evaluation of the level of blood gases and the availability of a team of trained personnel for possible assisted respiration is invaluable if we are to do all in our power to save these patients.-Iam, etc.,
Postsplenectomy Thrombocytosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smallpox Vaccination Risks and Public Policy
Authors: J. Michael Lane, Joel Goldstein
Journal: Annals of Internal Medicine (2004)

Letters6 January 2004Smallpox Vaccination Risks and Public PolicyJ. Michael Lane, MD, MPH and Joel Goldstein, MDJ. Michael Lane, MD, MPHFrom Atlanta, GA 30307; and The Children's Clinic; Morrow, GA 30260.Search for more papers by this author and Joel Goldstein, MDFrom Atlanta, GA 30307; and The Children's Clinic; Morrow, GA 30260.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-1-200401060-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Cooper's letter and agree with him completely. Exhalation of variola virus is reduced by wearing a simple surgical mask (1). We erroneously extrapolated that datum into use of an N95 respirator. In addition to Dr. Cooper's points, the edema and facial distortion of patients with smallpox make N95 respirators impractical.Reference1. Downie AW, Meiklejohn M, St Vincent L, Rao AR, Sundara Babu BV, Kempe CH. The recovery of smallpox virus from patients and their environment in a smallpox hospital. Bull World Health Organ. 1965;33:615-22. [PMID: 4285461] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Atlanta, GA 30307; and The Children's Clinic; Morrow, GA 30260. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEvaluation of 21st-Century Risks of Smallpox Vaccination and Policy Options J. Michael Lane and Joel Goldstein Smallpox Vaccination Risks and Public Policy Brian W. Cooper Metrics 6 January 2004Volume 140, Issue 1Page: 67KeywordsEdemaPublic policySmallpoxVentilators ePublished: 6 January 2004 Issue Published: 6 January 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Giardiasis
Authors: M. S. Wolfe
Journal: JAMA (1975)

The recent near-epidemic incidence of<i>Giardia lamblia</i>infection in visitors to the Soviet Union illustrates the importance of this intestinal flagellate as a cause of diarrhea in travelers worldwide. Clinical states range from the asymptomatic cyst-passing stage, to the chronic or subacute stage mimicking gallbladder or ulcer disease, to the transient or, rarer, persistent acute stage with steatorrhea and substantial weight loss. Symptoms may be related to IgA deficiency. Secondary lactose intolerance may follow eradication of the parasite. Diagnosis is usually based on repeated stool examinations or examination of duodenal contents. Quinacrine hydrochloride is the most effective treatment, but metronidazole and furazolidone are also useful. Contaminated water is the most likely source of infection. (<i>JAMA</i>233:1362-1365, 1975)
CHARLES McBURNEY (1845-1913)— POINT, SIGN, AND INCISION
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bilateral renal artery reconstruction. A ten-year arteriographic follow-up
Authors: R. H. Dean
Journal: JAMA (1976)

RECENT reports have indicated that operative treatment of renovascular hypertension in patients over 50 years of age is not warranted because of high morbidity, high mortality, and poor response.<sup>1,2</sup>This has not been our experience; of 162 patients with renovascular hypertension who underwent operative treatment, 70 were over 50 years of age and 56 (80%) of these were either cured or improved one year later.<sup>3</sup>The overall operative mortality was 8.6%, but five of the six operative deaths occurred in patients who were simultaneously undergoing operative treatment for abdominal aortic aneurysm or for occlusive disease. Only one death (1.9%) occurred in a patient in whom operative treatment was limited to the renal arteries. We describe a patient with severe renovascular hypertension and bilateral renal artery stenosis who was treated with bilateral aortorenal bypass grafts and who has had a ten-year serial arteriographic follow-up. <h3>Report of a Case</h3> A
Blood TfR+ exosomes separated by a pH-responsive method deliver chemotherapeutics for tumor therapy: Erratum
Authors: Lijun Yang, Donglin Han, Qi Zhan, Xueping Li, Peipei Shan, Yunjie Hu, Han Ding, Yu Wang, Lei Zhang, Yuan Zhang, Sheng Xue, Jin Zhao, Xin Hou, Yin Wang, Peifeng Li, Xubo Yuan, Hongzhao Qi
Journal: Theranostics (2020)
The Use of Insulin Pumps With Meal Bolus Alarms in Children With Type 1 Diabetes to Improve Glycemic Control
Authors: H. P. Chase
Journal: Diabetes Care (2006)

OBJECTIVE—The aim of this study was to determine whether the use of meal bolus alarms would result in fewer missed meal boluses per week in youth with type 1 diabetes using continuous subcutaneous insulin infusion (CSII) therapy.
MEDICAL CONTINGENT FEES.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases that mimic herpes simplex encephalitis. Diagnosis, presentation, and outcome. NIAD Collaborative Antiviral Study Group
Authors: R. J. Whitley
Journal: JAMA (1989)

A total of 432 patients underwent brain biopsy for presumptive herpes simplex encephalitis. Three patient groups were identified. The first group, 195 patients (45%), had herpes simplex encephalitis confirmed by the isolation of herpes simplex virus from brain tissue at biopsy (193 patients) or autopsy (2 patients). The second group, 95 patients (22%), had diseases that were identified but that were not caused by herpes simplex virus. Three subgroups were recognized: (1) 38 patients (9%) with treatable disease, (2) 40 patients (9%) with nontreatable but diagnosed viral infection, and (3) 17 patients (4%) with identified diseases neither of viral etiology nor treatable. The third group, 142 patients (33%), remained without a diagnosis. Clinical presentation of patients in the second group was similar to that of those with herpes simplex encephalitis and those without a diagnosis. Patients in the subgroup with nontreatable but diagnosed viral infections had the greatest likelihood of returning to normal. (<i>JAMA</i>. 1989;262:234-239)
Kupffer cell-derived 95-kd type iv collagenase/gelatinase b: characterization and expression in cultured cells
Authors: P WINWOOD
Journal: Hepatology (1995)

Release of 92-kd type IV collagenase/gelatinase, also known as gelatinase B, by inflammatory and tumor cells is increasingly recognized and is believed to facilitate cellular migration across basement membranes. It has been implicated in the pathogenesis of many diseases, but little is known of its cellular origin(s) and function in liver. In this study we have demonstrated synthesis and release of gelatinase B by human and rat Kupffer cells in primary culture. Northern analysis of RNA extracted from Kupffer cells stimulated with phorbol ester demonstrated a 2.8 kb transcript for gelatinase B. Immunoblotting and zymography of serum-free Kupffer cell-conditioned media demonstrated extracellular release of immunoreactive enzyme and gelatinase activity, Mr 92,000 (95,000 from rat cells). The organomercurial 4-aminophenyl mercuric acetate (APMA) activated the enzyme in vitro, indicating secretion primarily as a proenzyme. Stimulation of Kupffer cells by phorbol ester markedly induced gelatinase B release, which was inhibited by cycloheximide. In contrast, cycloheximide had no effect on constitutive secretion in culture, suggesting that there is some intracellular storage. Kupffer cell-derived gelatinase B was also partially purified and characterized. After separation by gelatin sepharose and gel filtration chromatography, gelatin-degrading activities of 95, 88, 75, and 65 kd were detected, the three lower-molecular-weight species probably representing activated forms. Enzyme activity was inhibited by ethyl-enediaminetetra-acetic acid (EDTA), but not by serine-and thiol-protease inhibitors, and was restored by zinc. Activity was also inhibited by tissue inhibitor of metallo-proteinase-1 (TIMP-1) and α-2 macroglobulin. The partially purified enzyme rapidly degraded denatured collagens (gelatin) as well as native types III, IV, and V collagens, but had no activity against casein, types I and VI collagens.
TRUST: Phase II trial of induction chemotherapy (CT) with FOLFOXIRI + bevacizumab (BV) followed by chemo-radiotherapy (CRT) + BV and surgery in locally advanced rectal carcinoma (LARC)
Authors: C. Vivaldi, P. Buccianti, G. Musettini, F. Bergamo, M.D. Rizzato, A. Sainato, A. Martignetti, S. Lucchesi, M. Franceschi, C. Boso, F. Pasqualetti, L. Ginocchi, F. Di Clemente, A. Gonnelli, L. Urbani, S. Montrone, I. Maretto, F. Sidoti, A. Falcone, G. Masi
Journal: Annals of Oncology (2016)
Medical education and professional competence
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atrial peptide study proceeds apace
Authors: M. F. Goldsmith
Journal: JAMA (1987)

"THE HEART SEEMS to be a very self-serving, self-centered organ, and it seems to have devised a way to protect itself against the volume overload of high blood pressure." So said Tadashi Inagami, PhD, professor of biochemistry and director of the Specialized Center for Research on Hypertension at Vanderbilt University Medical Center, Nashville, Tenn, at the annual meeting of the American Heart Association (AHA) in Dallas. The "way" Inagami referred to is atrial natriuretic factor. How this medium-size peptide secreted by the atria (and probably, it is now thought, to some degree by the ventricles as well) does its job, why it doesn't always do it adequately, and how its influence can be augmented are topics of intense interest and speculation among cardiovascular specialists. Pharmaceutical companies also are seeking to learn more about the material whose properties make Marc Cantin, MD, director of the Laboratory of Experimental Hypertension at the
Abstract 885: Induction of PRDX2 by H. pylori reduces ROS and promotes cancer cell survival and resistance to cisplatin
Authors: Sen Wang, Zheng Chen, Heng Lu, Shoumin Zhu, Dunfa Peng, Mohammed Soutto, Ahmed Gomma, Nadeem Bhat, Huma Naz, Zekuan Xu, Wael El-Rifai
Journal: Cancer Research (2019)

Abstract Background &amp; Aims: The antioxidant enzyme peroxiredoxin 2 (PRDX2) plays a critical role in regulating reactive oxygen species (ROS) levels in several diseases. Helicobacter pylori (H. pylori) infection is a well-known risk factor of gastric cancer. The role of PRDX2 in gastric tumorigenesis remains largely unknown. We investigated the molecular function and regulation of PRDX2 in response to infection with H. pylori and cisplatin treatment in gastric cancer cells. Methods:Western blots (WB) and quantitative real-time PCR (qPCR) analysis were performed on AGS, SNU-1 and MKN28 gastric cancer cell lines to detect PRDX2 expression levels with or without H. pyloriinfection (7.13 or J166 strain). We evaluated the levels of ROS by H2DCFDA staining. WB analysis was used to determine oxidative DNA damage and double stranded DNA breaks by using antibodies against 8-Oxo-guanine and p-H2AX. WB and NF-κb luciferase reporter assay were performed to investigate the link between PRDX2 and NF-κb signaling. ATP-GLO cell titer analysis was utilized to determine cell viability. Results:Our data indicated that PRDX2 mRNA and protein expression levels were induced byH. pyloriin AGS and SNU-1 cells. PRDX2 knockdown significantly increased ROS levels and 8-Oxoguanine staining followingH. pyloriinfection in both cells. These results were further confirmed by Western blot data showing that p-H2AX protein level was strongly induced in PRDX2 knockdown and H. pyloriinfected cells. Interestingly, Western blot data showed that TNF-αtreatment induced PRDX2 protein levels while Bay 11-7082 treatment decreased PRDX2 protein level in AGS and SNU-1 cells. At the same time, PRDX2 transient knockdown in both AGS and SNU-1 cells decreased p-P65 (S536) protein expression levels, nuclear localization of NF-κB-p65, and luciferase reporter activity (P&amp;lt;0.05). We also found that inhibition of PRDX2 significantly sensitized AGS and SNU-1 cells to cisplatin treatment. Conclusion:Our data indicates that knockdown of PRDX2 enhances ROS and DNA damage with H. pylori infection on gastric cancer cells after H. pylori infection and sensitizes gastric cancer cells to cisplatin treatment. Our results suggest a positive feedforward loop between PRDX2 and NF-kB to reduce ROS levels. KEY WORDS: PRDX2,H. pylori, gastric cancer, reactive oxygen species, DNA damage, NF-κb Citation Format: Sen Wang, Zheng Chen, Heng Lu, Shoumin Zhu, Dunfa Peng, Mohammed Soutto, Ahmed Gomma, Nadeem Bhat, Huma Naz, Zekuan Xu, Wael El-Rifai. Induction of PRDX2 by H. pylori reduces ROS and promotes cancer cell survival and resistance to cisplatin [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 885.
Manuscripts Approved for JNCI, February-March 1973
Journal: JNCI Journal of the National Cancer Institute (1973)

Manuscripts Approved for JNCI, February-March 1973 Get access JNCI: Journal of the National Cancer Institute, Volume 50, Issue 4, April 1973, Pages 1093–1095, https://doi.org/10.1093/jnci/50.4.1093 Published: 01 April 1973
A Disturbing Decline
Authors: David A. Braun, Brett Simchowitz, Galen V. Henderson, Paul E. Sax, Anand Vaidya
Journal: New England Journal of Medicine (2019)

In the early fall, a 29-year-old woman presented to a Boston-area urgent care clinic with a 6-day history of watery diarrhea and a 1-day history of fever. She had systemic lupus erythematosus complicated by nephritis, for which she had received rituximab. She was currently receiving treatment with mycophenolate mofetil, prednisone, and hydroxychloroquine. . . .