tbuckley/cabot-search huggingface dataset:
The Driving Forces of Human Nature and Their Adjustment: An Introduction to the Psychology and Psychopathology of Emotional Behavior and Volitional Control
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of the Mediterranean-type of diet to the risk of developing coronary heart disease: Principles and results from CARDIO2000 epidemiological study Demosthenes B. Panagiotakos, Christos Pitsavos, Christine Chrysohoou, Kostas Tzioumis, George Rembelos, Christodoulos Stefanadis, Pavlos Toutouzas. University of Athens, School of Medicine, Athens, Greece
Journal: Journal of the American College of Cardiology (2001)
Lead Absorption in Children
Authors: N. S. Gordon, E. King, R. I. Mackay
Journal: BMJ (1967)

RNA 615 -probability that the dangerous part of the cigarette is the part which is raised to a high temperature by the match flame.The carcinogenic factor(s) seem therefore to be contained in the smoke inhaled from the super-heated area.I should like to see an nquiry made into the habits of smokers in *or"er to distinguish those who inhale the first puff of a cigarette from those who reject it before inhaling the subsequent ones.-Iam, etc.,
Coproexamination for botulinal toxin and clostridium botulinum. A new procedure for laboratory diagnosis of botulism
Authors: V. R. Dowell
Journal: JAMA (1977)

Stool or serum specimens or both from 318 persons pertaining to 165 botulism investigations over a three-year period were examined. Botulinal toxin was detected in stools of 19 of 56 patients and in sera of 20 of 60 patients with clinical botulism; it was not detected in specimens from 246 persons with an illness other than botulism or well contacts of patients.<i>Clostridium botulinum</i>was identified in stools of 36 of 60 clinical botulism patients and in four of 27 asymptomatic contacts of patients with botulism victims, but not in stools of 65 persons not associated with confirmed botulism. When stool and serum samples were examined, confirmatory evidence was obtained for 72.9% of the botulism cases. Detection of botulinal toxin or<i>C botulinum</i>in the stool of a person should be considered evidence supporting the clinical diagnosis of botulism. (<i>JAMA</i>238:1829-1832, 1977)
TUBERCULOSIS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Abstract and Table
Authors: Consuelo Beck-Sagué, Tomás Guilarte, Robert Stempel
Journal: JAMA Pediatrics (2019)

Suzanne N. Landi, PhD; Sarah Radke, PhD; Stephanie M. Engel, PhD; Kim Boggess, MD; Til Stürmer, PhD; Anna S. Howe, PhD; Michele Jonsson Funk, PhD
Manual for the Medical Services of the Peiping Union Medical College Hospital.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The hyperviscosity syndrome
Authors: M. C. Perry
Journal: JAMA (1976)

DISORDERS that simultaneously involve several organ systems can produce confusing clinical pictures, and the combination of oronasal bleeding, visual impairment, and altered sensorium is particularly striking in this regard. Nevertheless, this is the picture that can be produced by an increased serum viscosity.<sup>1,2</sup>The bleeding characteristically occurs from the nose, mouth, or gums but may stem from the gastrointestinal or genitourinary tract. Postoperative oozing is also common. Ocular symptoms range from partial to complete loss of vision due to retinal hemorrhages, venous changes, or even papilledema. The neurologic disturbances, often known as the Bing-Neel syndrome, include headache, dizziness, true vertigo, deafness, nystagmus, diplopia, ataxia, paresthesias, and postural hypotension. Less often, congestive heart failure or renal impairment is seen. The main cause of the hyperviscosity syndrome is increased viscosity of the serum (as in macroglobulinemia or myeloma), although increased numbers of cells (polycythemia or leukemia) or increased resistance of cells
Prospective study of biomarkers in squamous cell carcinoma of the anal canal (SCCAC) and their influence on treatment outcomes: Final results.
Authors: Camila Motta Venchiarutti Moniz, Rachel Pimenta Riechelmann, Suilane Coelho Ribeiro, Thomas Giollo Rivelli, Giovanni Mendonca Bariani, André Chen, Rejane Franco, Caio Nahas, Allan Andresson Lima Pereira, Cintia Ortega, Jorge Sabbaga, Sibele Meireles, Renata A. Coudry, Paulo Marcelo Hoff
Journal: Journal of Clinical Oncology (2017)

3577 Background: While chemoradiation (CRT) is a curative treatment for SCCAC, many patients (pts) present primary resistance. As a rare tumor, the predictors of response in this setting remain unknown. Methods: Prospective cohort study aimed to evaluate predictive biomarkers (Ki-67, PD-L1, Human papillomavirus (HPV), HIV status and mutations in tumoral DNA) associated with complete response (CR) following standard CRT for localized SCCAC. Eligible pts had T2-4/N0-3/M0 disease and were candidates to standard CRT. CR at 6 months (m) measured by RECIST 1.1 was the primary endpoint. DNA mutations were analyzed by next-generation (NGS) TruSight Tumor26 panel. HPV positivity was tested by PapilloCheck Test. KI-67 and PD-L1 were evaluated by immunohistochemistry. Results: 78 pts were recruited from Jan/2011 to Dec/2015. 75 were evaluable for response. Median age 57 years; 49 (65%) were stage III, and 9 (12%) were HIV+. At 6m 47 (62.7%) had CR, 18 (24%) partial response (PR) and 10 (13.3%) disease progression. HPV was evaluated in 67 and found in 47 (70.1%), the majority HPV16. PD-L1 was tested in 61, 10 (16.4%) had &gt; 1% positive expression. Ki-67 was performed in 65, a median was 50% (1-90%) per patient. Clinical stage, HIV status, median KI-67, HPV and PD-L1 positivity, and treatment interruption were tested as predictive factors of CR in 6m by logistic regression. On multivariable analyses, ECII patients were 4.7 more likely to achieve CR than ECIII (OR 4.70 CI95%1.36-16.30; p = 0.015). HIV was borderline significant (OR 2.53 CI95% 0.9-7.1; p = 0.079). Analyzing the patients with PR and CR HIV+ was significantly associated with poor response. Patients HIV- were 5.7 more likely to achieve CR or PR (OR 5.72 CI95%2.5-13.0; p &lt; 0.001). 25 patients had tumor samples proper for NGS, 17 had at least one pathogenic mutation. The most common mutated genes were PIK3CA and MET in 6. There was no differences in CR rates according to MET (50% vs 47.3%, p = 1) or PIK3CA (33.3% vs 47.3%, p = 0.6) mutation status. TP53 codon 72 polymorphism was present in 72% (n = 18) and was not associated with CR (44% VS 57%, p = 0.6). Conclusions: Our study suggests that HIV+ pts are less responsive to CRT.
Phase II study of the combination of carboplatin and irinotecan in elderly patients with small cell lung cancer.
Authors: Y. Murata, T. Hirose, T. Yamaoka, T. Shirai, K. Okuda, T. Sugiyama, S. Kusumoto, T. Ohnishi, T. Ohmori, M. Adachi
Journal: Journal of Clinical Oncology (2010)

e18033 Background: More than 50% of lung cancer patients are diagnosed when they are over the age of 65, and about 30% are over 70. Elderly patients are at higher risk of treatment-related death and toxicity. Carboplatin is an analog of cisplatin with reduced renal, neurologic, and gastrointestinal toxicity. Irinotecan achieved a 47% overall response of patients with refractory or relapsed SCLC. Carboplatin and irinotecan show no cross- resistance and have shown synergistic effect in a preclinical study. The aim of the present phase II study was to assess the antitumor activity and toxicity of the combination of irinotecan and carboplatin in elderly patients with previously untreated SCLC. Methods: Patients with SCLC were eligible if they had a performance status of 0 to 2, were 70 years or older, and had adequate organ function. Patients were treated with AUC 5 min/mL of carboplatin on day 1 and with 50 mg/m2 of irinotecan on days 1 and 8. The trial was designed as a phase II study, with response rate as the primary endpoint. A planned sample size was 26. Results: From October 2005 through October 2009, 30 patients (26 men and 4 women; median age, 76 years; age range, 70 to 86 years) were enrolled. Nine patients had limited disease and 21 patients had extensive disease. The overall response rate was 83.3% (95% CI: 65.3-94.4%). The median survival time was 16.3 months (range, 3 to 34 months). The median progression free survival was 9 months (range, 1 to 27 months). Grade 3 to 4 hematologic toxicities included neutropenia in 83.3% of patients, thrombocytopenia in 46.7%, and anemia in 60.0%. Grade 3 to 4 nonhematologic toxicities included infection in 23.3% of patients, diarrhea in 20.0%, and nausea in 3.3%. There was no treatment-related death and drug induced pneumonitis. Conclusions: This combination chemotherapy is effective for SCLC and safe for elderly patients. No significant financial relationships to disclose.
THE JOURNA OF THE AMEICAN MEICAL ASSOCIATION
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Oxygen in myocardial infarction.
Journal: BMJ (1976)

where there has been close contact with pigs, but this is the first report of its case-to-case transmission.If this virus should spread, and if it retains or acquires the virulence for man ofthe 1918 virus, then the world could be faced with a similar pandemic.The 1918-19 influenza pandemic not only caused many deaths among the elderly but also an unusually high mortality in young adults.5At the present time many people over about 50 years of age possess serum antibodies against the swine virus; a swine influenza pandemic now might therefore spare older people, but younger adults and children would be expected to possess no basal immunity.The epidemiological features of the swine influenza virus are under close scrutiny by the Centre for Disease Control in Atlanta, USA, and by the World Health Organisation.Plans are in hand to start large-scale production of killed vaccine if evidence of significant spread appears.Careful observation is being kept in Britain, where the Department of Health, the Medical Research Council, and the Public Health Laboratory Service, together with vaccine manufacturers and field workers, are also putting preliminary plans into operation.Small amounts of killed vaccine are being made for clinical trials-in order, for example, to determine the dose that will ensure an adequate serological response, particularly in young adults and children who might respond poorly to a completely new influenza vaccine; they may require two injections.Live, attenuated vaccines will also be prepared, though they may well not be available soon enough to combat the first effects of a pandemic because their development and the essential potency and safety testing takes time.Nevertheless, their study is important; many workers believe that the even'tual control of pandemic influenza is most likely to be achieved by means of live vaccines which can be given easily and economically by the nasal route.
Dedication of Hospital.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Influence of Laparotomy on the Gastric Motor Mechanism
Journal: Journal of Clinical Investigation (1936)

The Influence of Laparotomy on the Gastric Motor Mechanism."Page 463, 7th line from end of abstract, for sentence " Forty-eight hours subsequent to her- niorrhaphy there was gas-ether anesthesia" read " Forty-eight hours subsequent to herniorrhaphy there was definite hypermotility."
LETTER FROM PARIS.
Authors: None A. B.
Journal: JAMA (1889)

(FROM OUR REGULAR CORRESPONDENT.) Dr. Guéniot on the Causes and Treatment of the severe or obstinate Vomiting of Pregnancy—Dr. Marc Sée on Congenital Hypertrophy of the Right Lower Extremity—Prof. Gayet on the Wearing of Celluloid Artificial Eyes—Antipyrin in the Treatment of Enuresis—The Incompatibility of certain Antiseptic Substances. At a recent meeting of the Academy of Medicine Dr. Guéniot read a memoir on the causes and treatment of the severe or obstinate vomiting of pregnancy. According to the author there are three principal factors concerned in the etiology of this form of vomiting, viz.: the uterus, the nervous system and the stomach, consequently it is against the alteration of one of these organs that the treatment should be directed. Thus, as regards the uterus, there may be ulceration of its neck, or a flexion of its body on the neck may be a source of irritation which reflects on the nervous
Cerebral Edema
Authors: W. Eugene Stern
Journal: JAMA (1966)

In a definitive and well-produced work, the authors bring up to date the mass of experimental evidence and clinical observation relating to the cerebral edemas (cerebral swelling). The authors discuss the present status of our knowledge of the fluid content of the brain and its solute, and the anatomical and physiological substrate of the blood-brain barrier which plays a role in certain forms of cerebral edema. The major emphasis of the monograph is a compilation of information gained from laboratory studies of various experimental brain edemas. In this sifting of many contributions, including substantive ones of their own, the authors have analyzed in a reasonably critical way, the validity and shortcomings of the experimental techniques. The pathophysiology of the human cerebral edemas and their clinical diagnosis is given thorough treatment. Due to the method of presentation, however, the reader must be alert not to confuse that which is related and
First report of a prospective trial of proton therapy and concomittant capecitabine for patients with nonmetastatic unresectable pancreatic adenocarcinoma.
Authors: Romaine Charles Nichols, Christopher G. Morris, Thomas J. George, Robert Anthony Zaiden, Elizabeth Johnson, Bestoun H. Ahmed, Meng Wei Ho, Soon N. Huh, Nancy Price Mendenhall, Bradford S. Hoppe
Journal: Journal of Clinical Oncology (2014)

e15223 Background: Review initial outcomes for patients enrolled on the University of Florida Proton Therapy Institute (UFPTI) PC01 protocol for patients with unresectable pancreatic cancer. Methods: The protocol received Institutional Review Board (IRB) approval in 7/2007. The first patient was enrolled in 4/2010. The accrual target was 66 patients to test if the Serious Adverse Event (SAE) ratecould be reduced from 15% (expected) to less than 5%. Protocol therapy consisted of proton therapy to a planning target volume (PTV) dose of 59.4 Cobalt Gray Equivalent (CGE) at 1.8CGE per fraction with concomitant Capecitabine (1000mg PO BID 5 days/week on radiation days). Only gross disease was targeted. Results: 12 patients were enrolled. 1 patient died of a gunshot wound 5 days after starting treatment so only 11 patients are reported. Median follow up from start of treatment: 13 months (range 2 to 21 months). Median age: 68 (range 51 to 86) years. Gender: Males 5, Females 6. Race/Ethnicity: 9 White, 2 Hispanic. Overall survival: 90% at 6 months and 60% at 12 months. Freedom from progression: 80% at 6 months and 53% at one year. Local control: 100% at 6 months and 86% at 12 months. Freedom from metastasis: 80% at 6 months and 67% at 12 months.No patient experienced any grade 3 or greater toxicity during treatment or during the follow up period.Grade 2 toxicity was limited to a single patient experiencing grade 2 fatigue. Median weight loss over the course of treatment was 1.7 (range: loss of 5.7 to gain of 4.9) Kg. 4 patients were deemed to have had an adequate radiographic response to radiotherapy so as to justify surgical exploration. Conclusions: Proton therapy to 59.4 CGE with concomitant Capecitabine was well tolerated with no grade 2 or greater gastrointestinal toxicities. 4 of 11 patients achieved a radiographic response allowing for attempted surgical resection. The study was closed to accrual on 9/1/2013 due to recognition that slow accrual made achievement of the primary study endpoint unlikely. At the same time, the lack of any meaningful gastrointestinal toxicity suggests significant opportunities for treatment intensification when proton therapy is used in this setting. Clinical trial information: NCT00685763.
In This Issue
Journal: Journal of Clinical Investigation (2006)

Bradykinin flows through the fountain of youthHow do angiotensin-converting enzyme inhibitors provide benefits in diabetic nephropathy and in other age-associated disorders, such as Alzheimer disease, congestive heart failure, and myocardial infarction?Kakoki and colleagues provide some answers by showing that the bradykinin B2 receptor can suppress hyperglycemia-induced oxidative stress and mitochondrial damage (pages 1302-1309).In 12-month-old mice, many indicators of senescence (alopecia, skin atrophy, kyphosis, osteoporosis, testicular atrophy, lipofuscin accumulation in renal proximal tubule and testicular Leydig cells, and apoptosis in the testis and intestine), virtually absent in wild-type mice, were clearly apparent in diabetic mice and were markedly enhanced when the diabetic mice also lacked the bradykinin B2 receptor.Bradykinin's ability to suppress hyperglycemia-induced reactive oxygen species in cultured endothelial cells was dependent on NO.The most likely causal mechanism of the age-related phenotypes is hyperglycemia-induced oxidative stress, enhanced by lack of B2 receptors, which led to increased mitochondrial turnover and mitochondrial DNA mutations.These findings led the authors to suggest that premature senescence underlies many of the complications of diabetes and that bradykinin plays an important role in preventing their development by reducing oxidative stress.