tbuckley/cabot-search huggingface dataset:
Bridging to survivorship in breast cancer: How BMI weighs in.
Authors: Janet L. Espirito, Brian Turnwald, Robyn K. Harrell, Debajyoti Bhowmik, Neelima Denduluri, Barry Don Brooks, J. Russell Hoverman, Debra A. Patt
Journal: Journal of Clinical Oncology (2013)

32 Background: Obesity and depression complicate survivorship in early stage breast cancer (BC) by having a direct impact on survival and morbidity among patients (pts) who complete treatment (tx). The prevalence of obesity after BC tx in the community and concordance with BC tx type is poorly described, but important as we characterize risks of tx and optimize goals for survivorship care planning. Methods: We queried the electronic health record (EHR), iKnowMed, from a large network of community oncology practices for pts diagnosed with stage I-III BC from 2007-2010 with at least 5 office visits and follow up through 11-2012 for our retrospective study. We excluded pts who developed metastatic disease or died. We stratified pts by chemotherapy (CT) utilization (yes/no), hormone receptor (HR) status, age, and documented body mass index (BMI) at first office visit and annually. We evaluated changes in BMI characteristics by tx cohort. Results: We identified 8,506 pts with a documented BMI at first office visit and 1, 2, and 3 years (yrs) thereafter. 4,369 (51% of the total) pts received adjuvant CT and 4,137 (49%) did not. 6,897 pts (81%) were HR positive. Baseline BMI between tx cohorts were similar, though the prevalence of overweight (31%) and overweight or obese (68%) is high. Percent change of BMI at 3 yrs varied significantly between T cohorts (p&lt;0.01) with greater rise among the cohorts who received CT in comparison to those who did not. Pts receiving CT were 46% more likely to have a 5 point or more increase in BMI at 3 yrs compared to pts that did not receive CT (OR 1.46, CI[1.08-1.96]). A stronger association for BMI increase of at least 0.5 points at 3 yrs (OR 1.53, CI [1.4-1.7]) was also observed amongst pts who received CT compared to those that did not. HR positive pts were less likely than HR negative or unknown pts to increase their BMI by at least 0.5 points (OR 0.84, p&lt;0.01), but there was no difference at detecting a difference of 5 points in BMI (OR 0.88, p=0.49). Conclusions: With 3 yrs of follow up, overweight and obese status is remarkably common among BC survivors in the community and appears to be more prevalent after CT tx. Determinants of obesity require further study and point to necessary intervention to improve the health of early stage BC pts.
Continuing Education Opportunities for Physicians
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term Study of Disodium Cromoglycate in Treatment of Severe Extrinsic or Intrinsic Bronchial Asthma in Adults
Journal: BMJ (1972)

The results are reported here of a long-term double-blind controlled clinical trial of disodium cromoglycate (D.S.C.G.) and isoprenaline, D.S.C.G. alone, isoprenaline alone, and a placebo given as a powder for inhalation in the treatment of severe bronchial asthma. At the end of one year 16 out of 20 patients on D.S.C.G.-isoprenaline remained on the allocated capsules, compared with 10 out of 15 on D.S.C.G., 5 out of 20 on isoprenaline, and 3 out of 19 taking the placebo. The differences between each of the D.S.C.G.-isoprenaline and D.S.C.G. regimens compared with the isoprenaline and placebo regimens were statistically significant. After eight weeks on four capsules a day the patients in each group were allocated at random so that half continued on full dosage and half on a reducing regimen. At the end of the year there was no significant difference in the failure rate between patients allocated the full dosage and the patients on the reducing dosage. The capsules were well tolerated and toxicity to D.S.C.G. was not observed.
Association News.
Authors: H. L. E. Johnson
Journal: JAMA (1902)

<h3>Railroad Rates for Saratoga Meeting.</h3> The Committee on Transportation has been making every endeavor to secure a railroad rate of one fare for the round trip with a thirty-day time extension, but has been unable to have the railroads grant the request. The Trunk Line Association, which in this instance under railroad regulations has the deciding of the matter of rates, etc., has finally decided to grant a rate of a fare and a third on the certificate plan, with an extension time limit to July 2, and make a fifty-cent charge on all tickets extended beyond June 16, that is to say, those beginning their return journey not later than June 16 will not be charged the fifty-cent fee extra, but in all cases where the return trip is begun after June 16, and on or before July 2, a fifty-cent fee will be charged. In purchasing tickets to
Sewage Sludge as a Source of Cadmium in Soil-Plant-Animal Systems
Authors: D. E. Baker, M. C. Amacher, R. M. Leach
Journal: Environmental Health Perspectives (1979)

The objective of this presentation is to relate the abundance and mobility of Cd in components of terrestrial ecosystems with implications for land utilization of sewage sludge.The uptake of Cd by crop plants is a function of the quantity of the element in the soil plus other soil factors affecting the Cd ion activity or electrochemical potential at the plant root surface.The natural abundance of Cd in soils has been reported as 0.5 j,ug/g which is higher than the background level of 0.2 ,ug/g found in soils studied in Pennsylvania.Experimental results indicate that the plant availability of Cd increases with each soil addition.While the plant availability of Cd is decreased by liming to increase soil pH, it has not been possible to add Cd salts or sewage sludge Cd without significantly increasing plant uptake.Field studies have shown that land application of sewage sludge can be expected to increase the Cd concentration of corn leaves from a range of 0.05-0.1 ,ug/g to 1-3 ,ug/g.Two years after the last applica- tion of sludge which added up to 10 ppm Cd to the surface soil, corn grain, sorghum grain, wheat grain, and potatoes showed a 10-to 15-fold increase in Cd over background levels.Etudies were conducted with chicks, laying hens, and meadow voles (Microtus Pennsylvanias) to assess ttte impact of this increase in plant Cd upon the food chain.Corn and sorghum plants were grown on soils with either inorganic or sludge fertilizer for the purpose of producing herbage for use in feeding trials with meadow voles.Eight diets and a synthetic control diet were formulated to study the effect of source (plant vs. inorganic) of Cd on tissue accumulation.Significant accumulation of Cd occurred in kidney and liver, but not muscle, of voles fed diets containing sludge fertilized corn (1.09 ,tg/g) or sludge fertilized sorghum (2.76 ug/g).The source of Cd had little influence on tissue accumulation.In studies with broiler chicks and laying hens, natural diets containing 0.2 ppm Cd were supplemented with 3 ppm of this element.As with the meadow voles, Cd readily accumulated in liver and kidney.Although the results were not statistically significant, 3 ppm dietary Cd doubled muscle Cd content.There was no transfer of Cd to egg in a long term (12 month) experiment with laying hens.Soil management programs have been developed to maintain animal dietary levels of Cd at less than 1.0 ,tg/g from the use of sewage sludge on land in Pennsylvania.However, it is concluded that this level over time may cause a significant accumulation of Cd in animal tissues.Interpretation of these results in relation to those for human intake of Cd and the long range health effects of Cd is required for the proper monitoring of sewage sludge applications on land used for production of crops which enter the food chain.
Status of the 1990 Objectives on Misuse of Alcohol and Drugs
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA OFFICIALS 1982-1983
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tests on Sera for Toxoplasmic Uveitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE HOSPITAL'S NEED OF A DENTAL STAFF
Authors: A J Flanagan
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accidental Poisoning
Authors: Allan B. Coleman
Journal: New England Journal of Medicine (1967)

PRIMUM non nocere was the ancient injunction to physicians. Yet modern drugs are so potent as to make the physician (iatros) the source of disorders ("iatrogenic") upon occasion. Similarly, household substances and home remedies, familiar but deadly, are the cause of numerous poisonings annually. Thus, the benefits of advancing technology are tempered by their inherent dangers. The poison list, compiled by the Accident Prevention Branch, United States Public Health Service,1 of substances most frequently reported by brand name in 1965 reflects the buying habits of the housewife, and the contents of her bathroom, bedroom and kitchen. The "top ten" include . . .
Delafloxacin: A Review in Acute Bacterial Skin and Skin Structure Infections
Authors: L. J. Scott
Journal: Drugs (2020)

The global spread of antibacterial-resistant strains, especially methicillin-resistant Staphylococcus aureus (MRSA) for acute bacterial skin and skin structure infections (ABSSSIs), has driven the need for novel antibacterials. Delafloxacin [Quofenix™ (EU); Baxdela® (USA)], a new fluoroquinolone (FQ), has a unique chemical structure that enhances its antibacterial activity in acidic environments such as occurs in ABSSSIs (including S. aureus infections). Delafloxacin (intravenous and oral formulations) is approved in several countries for the treatment of adults with ABSSSIs (featured indication). In intent-to-treat analyses in pivotal phase 3 trials in adults with ABSSSIs, including those with comorbid disease, intravenous delafloxacin monotherapy (± oral switch after six doses) twice daily was noninferior to intravenous vancomycin + aztreonam for primary endpoints, as specified by the FDA (objective response rate at 48-78 h after initiation of therapy) and the EMA [investigator-assessed clinical cure rate at the follow-up visit at day 14 (± 1 day)]. Delafloxacin was generally well tolerated, with most treatment-related adverse events mild to moderate in severity and few patients discontinuing treatment because of these events. Relative to vancomycin + aztreonam (a non-FQ regimen), delafloxacin treatment was not associated with an increased risk of FQ-associated AEs of special interest. Given its unique chemical structure that confers novel properties relative to other FQ and its broad spectrum of activity against common clinically relevant Gram-positive pathogens, including against MRSA strains (± FQ-resistance mutations), and Gram-negative pathogens, intravenous delafloxacin (± oral switch) provides a novel emerging option for the treatment of adult patients with ABSSSIs.
Computers in medicine. A practitioner's comment
Authors: C. P. Kerr
Journal: JAMA (1983)

IT IS time for an office practitioner to comment on the rash of recent literature on computers in medicine.<sup>1-4</sup>Indeed, it is appropriate to ask if many office practitioners read these articles with any practical interest. INTERNIST-1, the chest pain protocol, INFERNET, ONCOCIN, and so on are unlikely to be used by most of us. As their respective authors correctly point out, they are at present mainly research tools, and teach us a lot about how medical reasoning works—principally from the computers' shortcomings. Thus, it is comforting to learn that INTERNIST-1 also has difficulty reasoning temporally, anatomically, and pathophysiologically at the same time. Nonetheless, it is clear that computers are here to stay, and not just at busy emergency rooms or the university hospitals. Because of the incredible price breakthroughs, it is likely that<i>every</i>medical practice will employ or share one within the next few years. The computer
THE ARMY EMERGENCY RATION.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disseminated Cryptococcus treated with transfer factor
Authors: P. A. Gross
Journal: JAMA (1978)

Cardiac toxic reactions and pulmonary consolidation in the left lower lobe developed in a patient who was receiving amphotericin B therapy for cryptococcal meningitis. Following surgical resection of the lobe, multiple subcutaneous cryptococcal abscesses appeared. Flucytosine administered intravenously failed to eradicate the lesions. Transfer factor therapy and multiple drainage procedures eliminated the skin abscesses. Transfer factor therapy was administered for one year; the patient was asymptomatic 16 months after therapy was discontinued. (<i>JAMA</i>240:2460-2462, 1978)
<i>A Manual of Psychiatry.</i>Edited by Aaron J. Rosanoff, M. D., Clinical Director, Kings Park State Hospital, N. Y., Lieutenant Colonel, Officers' Section, Medical Reserve Corps, U. S. Army. Fifth Edition, Revised and Enlarged. (<i>New York: John Wiley and Sons, Inc.; London: Chapman and Hall, Limited, 1920.</i>)
Journal: American Journal of Psychiatry (1921)
应激、瘙痒和搔抓
Authors: H. Mochizuki, M.J. Lavery, L.A. Nattkemper, C. Albornoz, R. Valdes Rodriguez, C. Stull, L. Weaver, J. Hamsher, K.M. Sanders, Y.H. Chan, G. Yosipovitch
Journal: British Journal of Dermatology (2019)

特应性皮炎(湿疹)患者常报告应激是加重他们皮肤瘙痒的一个重要因素。这项研究调查了与健康对照相比,特应性皮炎受试者中急性应激对瘙痒、搔抓冲动和搔抓行为的影响。使用特里尔社会应激测试 (TSST) 以标准方式创建应激,在该测试中要求受试者执行公开演讲任务和心算。在第二次对照访视中不创建应激,而是让受试者观看无压力的风景视频。特应性皮炎受试者和健康受试者都在 TSST 后感到有压力。令人感兴趣的是,对应激更敏感的特应性皮炎受试者湿疹严重程度也更重。在 TSST 或风景视频前后,向各受试者的手臂涂抹天鹅绒芸豆(一种导致瘙痒的植物)提取物。在通过 TSST 使他们应激后,特应性皮炎患者报告的天鹅绒芸豆提取物所致瘙痒较轻,搔抓冲动较弱。但是,尽管报告了较轻的瘙痒,实际上他们在应激时对肢体的搔抓更明显。与对照风景视频条件相比,健康个体在应激条件下的瘙痒、搔抓冲动或搔抓行为无任何差异。这项研究显示,与健康个体相比,急性应激对慢性瘙痒患者的瘙痒和搔抓可能有不同的影响。应激在特应性皮炎患者中导致搔抓增多。随时间推移,此应激反应可导致搔抓皮肤损伤增多,因此加重湿疹和瘙痒。
Évaluation d’une intelligence artificielle de type réseau neuronal de convolution profonde pour la détection endoscopique des cancers gastriques précoces
Journal: Endoscopy (2019)

Introduction le cancer gastrique est la troisième cause de mortalité par cancer dans le monde. Une nouvelle intelligence artificielle de type réseau neuronal de convolution profonde (RNCP) a récemment été développée pour réaliser des tâches de reconnaissance visuelle. L’objectif de cette étude était de développer un système utilisant le RNCP pour détecter le cancer gastrique précoce sans zone d’ombre lors d’une endoscopie oeso-gastro-duodénale (EOGD).
Nodular regenerative hyperplasia of the liver graft after liver transplantation
Authors: E GANE
Journal: Hepatology (1994)

Nodular regenerative hyperplasia has not previously been reported in patients who have undergone orthotopic liver transplantation. In this report we describe the clinical, biochemical and histologic findings in nine liver transplant recipients in whom nodular regenerative hyperplasia developed between 6 and 144 mo (median, 64 mo) after transplantation. Six of the patients manifested features of portal hypertension (variceal bleeding, ascites, severe intractable peripheral edema), whereas three patients were asymptomatic at the time of diagnosis. All patients had elevated serum alkaline phosphatase (median, 269 IU; range, 159 to 1182 IU) and gamma-glutamyl transferase levels (median, 247 IU; range 104 to 1513 IU). Other liver function tests remained normal. In five patients, earlier biopsies had identified histological features of venous outflow block, consistent with azathioprine hepatotoxicity. All nine patients had been taking azathioprine up to the time of presentation. After withdrawal of azathioprine, liver function tests improved appreciably in five patients and histologic improvement was documented in four of these who underwent follow-up liver biopsies. In the remaining four patients progressive graft failure ensued and all subsequently underwent repeat liver retransplantation. At a certain stage, nodular regenerative hyperplasia, in the context of a liver graft, becomes an irreversible lesion, emphasizing the need for early identification and withdrawal of the agent. (Hepatology 1994;20:88–94.)