tbuckley/cabot-search huggingface dataset:
Pesticides: How Research Has Succeeded and Failed in Informing Policy: DDT and the Link with Breast Cancer
Authors: Mary S. Wolff
Journal: Environmental Health Perspectives (1995)

Investigation of chemical exposures as possible etiologic factors for breast cancer has not been a research priority in the United States, which is sur- prising given the evidence from animal studies that environmental chemicals cause cancer and reproductive dysfunction.Study of environmental chemicals has also been indicated by the failure of traditional epidemiologic methods to account for significant proportions of breast cancer inci- dence with other risk factors.The fact that breast cancer risk is strongly associated with reproductive hormones is a further clue that environmental chemicals should be investigated.In addition to cancer, specific outcomes that need to be explored are reproductive dysfunction, immunotoxicity and neurotoxicity.Policy guiding our research should encourage toxicologic investigations of exposures to environmental chemicals that use state- of-the-art methods to determine exposure and human health effects.Using the approach suggested by John McLachlan, functional toxicology should be used to assess the activity of chemicals with regard to these outcomes.Just as dioxin toxicity can be expressed as toxic equivalents, estrogenic activity, for example, can be characterized in terms of estrogenic equivalents.In addition to the need to undertake this kind of research, needs for methods development and creative research funding mechanisms are discussed.Prevention of breast cancer may require intervention at an early age.Better understanding of breast cancer etiology, and especially its environmental components, may lead us toward that goal.-
Abstract 1747: Therapeutic Potential of Mesenchymal Stem Cells Derived from Three Different Layers of Human Fetal Membrane in Hindlimb Ischemia Model
Authors: Kazuhiko Harada, Shunsuke Ohnishi, Kenichi Yamahara, Masaharu Sada, Shin Ishikane, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Kenji Kangawa, Soichiro Kitamura, Noritoshi Nagaya, Tomoaki Ikeda
Journal: Circulation (2008)

The fetal membrane (FM), which is reported to contain mesenchymal stam cells (MSC), has been regarded as an ideal source for regenerative medicine, although it is normally discarded after birth. Little information is available regarding the biological difference and therapeutic potential of MSC obtained from different layers of FM including amnion and chorion. We assessed the hypothesis that human FM-derived MSC (FM-MSC) might have therapeutic effects on hindlimb ischemia. FM was obtained following cesarean section and vaginal delivery of healthy donor mothers after obtaining informed consent. We mechanically and enzymatically separated human FM into three layers; amnion and inner and outer layers of chorion, and isolated dish-adherent cells from each layer of FM. These FM-derived cells showed similar surface antigen expression and pluripotency compared to bone marrow (BM)-derived MSC. Because cultured inner chorion-derived MSC (IC-MSC) secreted large amounts of growth factors including IGF-1(13.6 ± 0.08 ng/106cells/24hrs, p &lt; 0.001 vs. amnion or outer chorion-derived MSC (AM-MSC or OC-MSC)) and HGF (7.94 ± 0.67 ng/106cells/24hrs, p &lt; 0.001 vs. AM-MSC or OC-MSC) compared to AM-MSC or OC-MSC, we chose to use IC-MSC for further in vivo experiment. Hindlimb ischemia was induced in 6-week-old male NOD/SCID mice, which were divided into two groups: IC-MSC transplanted group (1 × 10 6 cells/50 μl PBS, n = 9), and control group (50 μl PBS, n = 10). IC-MSC was injected into ischemic hindlimb muscle at five different points. Laser Doppler perfusion analyses showed that the ischemic/nonischemic blood flow ratio was significantly increased in IC-MSC group compared to control group (0.468 ± 0.093 vs. 0.227 ± 0.045 respectively, p &lt; 0.01). Transplantation of FM-MSC showed significant neovascularization in murine hindlimb ischemia model. FM-MSC might have a potential to be an ideal source for treatment of ischemic cardiovascular disease.
Cardiovascular Proteomics
Authors: Rainer Klocke, Sergiu Scobioala, Sigrid Nikol
Journal: Cardiovascular Research (2006)

Traditional cardiovascular proteomics includes the comparative large-scale determination of protein profiles and the identification of individual proteins of myocardial tissue from different species including humans. The goal of these studies consisted, and still consists, in the establishment of comprehensive proteome databases. By comparison with protein profiles from diseased tissues such databases will enable to an increasing degree the fast identification of protein alterations accompanying or underlying cardiovascular diseases. Examples demonstrating the feasibility of this approach are already available. In combination with pathophysiological data the knowledge about protein alterations in diseased tissues will allow the identification of disease mechanisms and of candidates for therapeutic proteins, drug targets, and disease biomarkers. Thereby it provides the basis for therapies, including gene therapies, of cardiovascular diseases. These efforts will be supported by the use of animal models displaying significant degrees of similarity to human cardiovascular diseases.
Pulmonary Phycomycosis
Authors: Richard D. Meyer
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The article, "Pulmonary Phycomycosis Without Obvious Predisposing Factors" (235:1256, 1976), by Drs Record and Ginder deserves comment. Although the authors correctly note that patients with this infection normally suffer from severe underlying disease,<sup>1</sup>we were unable to find a case of phycomycosis (actually mucromycosis caused by any member of the family Mucoraceae), unless (1) the report was erroneous and confused Mucoraceae with Entomophthoracae infection, or (2) the patient infected with Mucoraceae (<i>Rhizopus, Mucor, Absidia</i>) indeed had a subtle underlying disorder, such as biochemical evidence of diabetes mellitus, or subsequently was shown to be compromised.<sup>2</sup> I daresay that since no glucose tolerance test result was reported for the patient infected with<i>Rhizopus</i>, his condition cannot be considered free of a predisposing factor, although the autopsy disclosed no underlying disorder. The role of the previous bacterial pneumonia is problematic.
Machine learning outperforms existing non-invasive tests as screening tool for liver fibrosis in the general population
Authors: Miquel Serra-Burriel, Isabel Graupera, Maja Thiele, Llorenç Caballeria, Dominique Roulot, Grace Lai-Hung Wong, Núria Fabrellas, Neil Guha, Anita Arslanow, Carmen Expósito, Rosario Hernández, Guruprasad Aithal, Peter Galle, Vincent Wai-Sun Wong, Frank Lammert, Castera Laurent, Aleksander Krag, Pere Ginès
Journal: Journal of Hepatology (2020)
Multistage Models for Carcinogenesis: Reply
Authors: Kenneth G. Manton, Ph.D., Eric Stallard
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Multistage Models for Carcinogenesis: Reply Get access Kenneth G. Manton, Ph.D., Kenneth G. Manton, Ph.D. Center for Demographic Studies Duke University 2117 Campus Drive, Durham, North Carolina 27706 Search for other works by this author on: Oxford Academic PubMed Google Scholar Eric Stallard Eric Stallard Center for Demographic Studies Duke University 2117 Campus Drive, Durham, North Carolina 27706 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 65, Issue 2, August 1980, Pages 215–216, https://doi.org/10.1093/jnci/65.2.215-a Published: 01 August 1980
Rationing, justice, and the American physician
Authors: W. A. Knaus
Journal: JAMA (1986)

There are two articles in this week's issue ofThe Journalthat address the important question of what happens when demand for sophisticated medical services, in this case intensive care treatment, exceeds supply. If you haven't already done so, read the article by Strauss et al<sup>1</sup>first. These investigators were able to cleverly relate the number of available intensive care unit (ICU) beds to physicians' admitting and discharge decisions by matching the number of open beds to the characteristics of patients admitted. What happened when there were few or no empty beds? Medical and surgical patients who were not very ill—for example, patients with chest pain but with a low probability of having a myocardial infarction—the "too healthy," were excluded. This study is the first to directly link daily variations in ICU bed availability to physicians' decision making. Its theme, however, is one that I increasingly hear during conferences
Carotid Endarterectomy
Authors: R D Cebul, J P Whisnant
Journal: Annals of Internal Medicine (1989)

Study Objective: To evaluate the usefulness of doing carotid endarterectomy in patients with symptomatic or asymptomatic carotid artery disease. Design: Synthesis and summarization of data on the untreated course of cerebrovascular disease, and review of selected evidence and expert opinion on the risks and benefits of endarterectomy and medical therapy. Main Results: There is a large body of data related to the untreated course of cerebrovascular disease, the efficacy of aspirin in patients with transient ischemic attacks, and the comparative responsiveness to surgery of symptomatic patients with different presentations. Randomized trials in progress will increase the knowledge about the effects of aspirin in asymptomatic patients, the comparative efficacy of aspirin and endarterectomy in asymptomatic and symptomatic patients, and the factors that influence surgical risk. Clinicians and investigators wish to define a more limited and precise set of indications for carotid endarterectomy. In setting standards, attention has properly focussed on "maximum acceptable complication rates," native stroke risk, and surgical efficacy for patients with different clinical presentations. Illustrative, acceptable surgical mortality rates are less than 1%, and stroke-related morbidity is less than 3% for patients who have had a transient ischemic attack; surgical mortality and stroke-related morbidity are less than 2% for patients with asymptomatic carotid stenosis. Medical comorbidity and angiographic findings are important factors affecting specific recommendations. Conclusions: Data from ongoing clinical trials will provide a more scientific foundation for recommendations about when to do carotid endarterectomy. Current evidence suggests that fewer endarterectomies should be done, and those on the basis of a more precise set of indications. Clinicians should consider the clinical presentation, the patient's comorbidity and native stroke risk, angiographic findings, and the experience of the surgical team.
Section 54.—Congenital Dysplasia and Dislocation of the Hip
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blue rubber bleb nevus syndrome
Authors: N. Suksamanapun, A. Trakarnsanga, T. Akaraviputh
Journal: Endoscopy (2011)

Blue rubber bleb nevus syndrome (BRBNS) is a very rare condition. Herein we report the case of a 14-year-old girl who presented with chronic anemia that had required multiple blood transfusions and iron supplementation for many years. She had also received steroids. Physical examination revealed multiple small lesions on the dorsum of her feet ([Fig. 1]).
POSTPONED PAN-AMERICAN MEDICAL CONGRESS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prenatal Vaccinia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma tissue factor and tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation
Authors: Minori Shimura, Hideo Wada, Yoshihiro Wakita, Tutomu Nakase, Katsuyo Hiyoyama, Shozaburo Nagaya, Yositaka Mori, Hiroshi Shiku
Journal: American Journal of Hematology (1996)

We measured the plasma levels of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in patients with disseminated intravascular coagulation (DIC) to examine the relationship between TFPI and vascular endothelial cell injury. Plasma TF (273 ± 90 pg/ml) and TFPI (252 ± 125 ng/ml) levels were significantly increased in patients with DIC compared with non-DIC patients. Plasma TF antigen level was significantly increased in pre-DIC patients (285 ± 85 pg/ml), while the plasma TFPI level (152 ± 54 ng/ml) was not markedly increased in such a state. The plasma TF/TFPI ratio was high in the pre-DIC patients (2.10 ± 0.90), and low in the DIC patients (1.40 ± 0.87) and healthy volunteers (0.84 ± 0.26). There was no significant difference between the DIC patients with a good outcome and those with a poor outcome in terms of plasma TF levels, although the plasma TFPI level in the DIC patients with a good outcome (289 ± 133 ng/ml) was significantly higher than that in those with a poor outcome (187 ± 75 ng/ml). During the clinical course of DIC, plasma TF antigen was increased first, and an increase of the plasma TFPI level followed the increase in plasma TF level. These findings suggest that plasma TFPI is released from vascular endothelial cells and it may reflect vascular endothelial cell injury. It is conceivable that TF and TFPI may play an important role in the onset of DIC. © 1996 Wiley-Liss, Inc.
The FGF system has a key role in regulating vascular integrity
Authors: Masahiro Murakami, Loc T. Nguyen, Zhen W. Zhuang, Karen L. Moodie, Peter Carmeliet, Radu V. Stan, Michael Simons
Journal: Journal of Clinical Investigation (2009)

During the preparation of the manuscript, different fields of the same sample for WGA immunofluorescence staining were mistakenly used to represent 2 distinct treatment groups on 2 occasions, in Figures 2 and7, and some of the raw data for the earlier experiments were lost due to poor record keeping.All authors have agreed to retract the article.
Vasoactive drugs
Authors: G. Baltopoulos, G. Kofinas, G. Panetsos, G. Fildisis, Alexandra Kakouri, N. Maynard, M. N. Smithies, B. Mason, D. J. Bihari, Th. Schricker, K. Träger, M. Holland, B. Kugler, M. Géorgieff, O. Boyd, R. M. Grounds, E. D. Bennett, R. Germann, M. Haiajackl, H. Sparr, W. Hasibeder, B. Friesenecker, G. Luz, R. Plattner, H. Pernthaler, K. -F. Bodmann, S. Tröster, R. Clemens, H. -P. Schuster
Journal: Intensive Care Medicine (1992)
A novel, smartphone-based scleral image capture technique accurately determines serum bilirubin level and can be used for home-based monitoring of patients discharged from hospital, after an episode of acute decompensation
Authors: Rahul Kumar, Miranda Nixon, Eman Ibrahim Alabsawy, Ahmed Adel Amin, Felix Outlaw, T leung, Raj Mookerjee
Journal: Journal of Hepatology (2020)
Drug Evaluations
Authors: Louis Lasagna
Journal: JAMA (1987)

<i>AMA Drug Evaluations</i>has been issued every two to four years since 1971 and is intended to provide health professionals with up-to-date, unbiased information on the clinical use of drugs. It serves a role quite different from that of a book like Goodman and Gilman. The latter is encyclopedic, while<i>Drug Evaluations</i>aims to provide a distilled, more practical therapeutic message. Many people are involved in its production: American Medical Association staff, medical staff of pharmaceutical companies, and 512 consultants chosen by the American Society for Clinical Pharmacology and Therapeutics. Unrestrained by Food and Drug Administration—approved labeling (as it should be!), the volume recognizes the legitimate use of drugs regardless of their regulatory status and even includes drugs not as yet available on the US market. Reviewing a tome of this size in such a way as to do it justice is always a challenge. One ends up dipping into
THE WAR SERVICE OF THE MEDICAL PROFESSION
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Community-Wide Emergency Medical Services
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ineffectiveness of topical idoxuridine in dimethyl sulfoxide for therapy for genital herpes
Authors: D. L. Silvestri
Journal: JAMA (1982)

The efficacy and toxicity of topical applications of 30% idoxuridine in dimethyl sulfoxide, dimethyl sulfoxide alone, or saline in 96 recurrent and 39 first episodes of genital herpes simplex virus (HSV) infection were compared. Drug was applied to lesions four times daily for seven days. In recurrent episodes, the duration of viral shedding after beginning idoxuridine in dimethyl sulfoxide use was significantly shorter (0.6 days) than with dimethyl sulfoxide (1.4 days) or saline (2.0 days) (<i>P</i>&lt;.05). In primary episodes, viral shedding lasted 2.6 days with idoxuridine in dimethyl sulfoxide and 8.4 days with dimethyl sulfoxide or saline. Idoxuridine in dimethyl sulfoxide had no effect in recurrent or primary HSV on duration of symptoms, new lesion formation, healing time, or risk of subsequent recurrence. Complications in patients given idoxuridine in dimethyl sulfoxide included local burning, generalized contact dermatitis, and vulvar carcinoma in situ. Thirty percent idoxuridine in dimethyl sulfoxide has no effect on clinical manifestations of genital HSV infection and may be hazardous. (<i>JAMA</i>1982;248:953-959)