tbuckley/cabot-search huggingface dataset:
A2.13 Phenotypic and Molecular Profile of Innate Lymphoid Cells in Chronic Synovial Inflammation
Authors: Hulda Sigridur Hreggvidsdottir, Jenny Mjösberg, Jochem Bernink, Dominique Baeten, Hergen Spits
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background and Objective</h3> Innate lymphoid cells (ILCs) represent a novel family of effector and regulatory cells in innate immunity and tissue remodelling. The family comprises several phenotypically and functionally distinct subsets that produce various cytokines such as IL-22, IL-17, IFNγ, TNF, IL-13 and IL-5, of which many have been shown to be important in arthritis pathogenesis. The IL-17 and IL-22 producing ILCs are of major interest as they are implicated in chronic gut inflammation. Based on the broad clinical overlap between inflammatory bowel disease and spondyloarthritis (SpA) and the clinical importance of IL-17 in SpA we hypothesise that IL-17 and IL-22 producing ILCs contribute to inflammation and remodelling in SpA synovitis. As these cells have never been described in the joint our first aim was to characterise ILC in chronic inflammatory arthritis. <h3>Material and Methods</h3> ILCs (lineage negative, CD45<sup>+</sup>CD127<sup>+</sup>) were analysed and sorted by flow cytometry from synovial tissue and fluid from rheumatoid arthritis (RA) and SpA patients as well as in blood from SpA patients and healthy donors. mRNA expression of sorted and expanded cells was analysed by qPCR. <h3>Results</h3> ILCs were identified in blood as well as in synovial tissue and fluid from both RA and SpA patients. The frequency of ILCs was higher in the inflamed joint (0.5–3.3% of the lymphocyte population) than in the peripheral blood compartment (0.1%). In blood, there was no marked difference in the frequency of the different ILC subset between healthy controls (n = 10) and SpA patients (n = 5). In the inflamed joint, the ILC3 (CRTH2-NKp44+ckit+) and ILC1 (CRTH2-NKp44-ckit–) populations, previously shown to express IL-22 and IFNγ respectively in other tissues, were present in all samples whereas the Th2 cytokine expressing ILC2s (CRTH2+) were found in very low frequencies. Frequencies of ILC subpopulations varied considerably between patients and no differences could be detected between RA and SpA patients. qPCR analysis of expanded cells revealed that ILC1 expressed TBX21 whereas ILC3 expressed RORC. Accordingly, stimulated ILC3 expressed transcripts for both IL-23R and IL-22 but not IL-17. <h3>Conclusions</h3> ILC1 and ILC3 are present in the chronically inflamed joint and express the key transcription factors associated with specific cytokine profiles. These data indicate that ILC could contribute to local cytokine-driven immune alterations in SpA and RA.
More magazines forgo tobacco ads, some by choice, many by chance
Authors: M. F. Goldsmith
Journal: JAMA (1994)

UPDATING the<i>JAMA</i>list of magazines that carry no advertisements for cigarettes or other tobacco products is a daunting task. Hundreds of new periodicals debut each year even as hundreds of others disappear. Yet the Medical News &amp; Perspectives staff perseveres, trying to make it easier for physicians to fill their reception rooms with reading material whose commercial content is not hazardous to their patients' health. Thanks also to the contributions of a number ofThe Journal's readers, particularly the members of DOC (Doctors Ought to Care), a group of physicians dedicated to educating the public about the causes of preventable illness, this list contains many new tobacco-free titles along with the no-smoking standbys. A word of warning is in order, however. According to Alan Blum, MD, associate professor of family medicine at Baylor College of Medicine, Houston, Tex, chair of DOC, and former<i>JAMA</i>Fishbein Fellow in Medical
P122 No abstract assigned to this number
Authors: A Keys, T Wilkinson, K Staples, M North, S Pink, S Wilson, I Kilty, R Djukanovic, A Ward, K Chana, M Thomas, S Fenwick, L Donnelly, A Ling, D Elward
Journal: Thorax (2011)

Paired sputum IL-18 levels at baseline and exacerbation.
Anatomical Record, Philadelphia
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Miscellany
Journal: JAMA (1930)

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REPORT OF THE READING PATHOLOGICAL SOCIETY
Authors: W. W. Moxhay
Journal: BMJ (1853)

Nov. 18, the imperfect sight either to encephalic tumour, or to im- plication of the frontal nerve, examination of the urine, a few days later, furnished a much more satisfactory clue to the symptom.The fluid was highly albuminous.We now ascertained from relatives that the daily amount was small (a fact previously denied by the patient).A few days later, the eyelids were distinctly, though very slightly, oedematous; the ankles remained free from dropsy throughout.The most active measures failed to produce any secretion from the skin, which continued to the last day dry and harsh.Between this period and that of the patient's death, on the 29th of November, one or two circumstances occurred worthy of Inote.The hydroclhloric acid test succeeded strik-ingly; the expired air gave thick opaque fumes: but in this inistance, as in nany we have seen in the wards together, the breath was of strongly urinous odlour-a state quite as si(lgnificant of urwinia, as an affirmative result by Frerichs's test.For several days before his deceasc, the paticent had .u}(enti(iyspmea, as I would call it-a dyspna evidlenitly depcndhiLt oni the mnorlid state of the blood: for there was no pulmuotnary nior cardiac affection to exp,lain it; the percussion-sound was excellent everywhere; there was no rhonchuis, no serious alteration of the respirationi-sound, and no cardiac (lisease.The pulse-respiration ratio averaged during this time :3:1, both pulse an(i respiration being, ab- solutely speakinig, very frequtiernt, namely 120 and 40.But there was an amiiounit of breathing, distress materially greater than.attelnds a res)iration of forty per lminute: to this the poisone(d bloodl wvas the apparent clue.Now, remarkably enoughi, this patient remained, almost to the last iiiomient, tree froml the siiore ordlinary effects of ure- mic poisoning.The braini and cor(l gave no Bign of suffering;
LACTIC ACID AND HYPERURICEMIA OF FAULTY RENAL URATE TRANSPORT
Journal: JAMA (1967)

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Psychiatric Illness in MDs A Problem for Profession
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low-dose amiodarone for maintenance of sinus rhythm after cardioversion of atrial fibrillation or flutter
Authors: A. T. Gosselink
Journal: JAMA (1992)

<h3>Objective.</h3> —To study efficacy and safety of low-dose amiodarone for maintenance of sinus rhythm after electrical cardioversion of atrial fibrillation or flutter. <h3>Design.</h3> —Nonrandomized trial; mean duration of follow-up, 20.7 months. <h3>Setting.</h3> —Referral center; institutional practice; both hospitalized and ambulatory care. <h3>Patients.</h3> —Eighty-nine consecutive patients having chronic atrial fibrillation or flutter and eligible for cardioversion. Patients had failed previous treatment aimed at maintaining sinus rhythm. During follow-up one patient was withdrawn because of side effects; all patients were available for follow-up. <h3>Intervention.</h3> —Before cardioversion, patients received 600 mg of amiodarone daily during a 4-week loading period. After conversion, the daily maintenance dose was 204±66 mg (mean±SD). <h3>Main Outcome Measures.</h3> —Arrhythmia recurrence and adverse effects causing drug discontinuation. <h3>Results.</h3> —During loading, 15 patients (16%) converted, and after electrical cardioconversion, 90% of all patients had sinus rhythm. Actuarially, 53% of these patients were still in sinus rhythm after 3 years. In patients with compromised left ventricular function, 93% maintained sinus rhythm after 6 months. One patient died due to congestive heart failure. Intolerable side effects occurred in one patient. No proarrhythmia was observed. Logistic regression analysis revealed that amiodarone was ineffective in patients with mitral stenosis or chronic arrhythmia. <h3>Conclusions.</h3> —Low-dose amiodarone is effective for maintaining sinus rhythm in patients with difficult to treat chronic atrial fibrillation or flutter and is associated with a low incidence of serious side effects. (<i>JAMA</i>. 1992;267:3289-3293)
Neutropenia associated with maprotiline
Authors: R. S. Ream
Journal: JAMA (1982)

MAPROTILINE hydrochloride is a new tetracyclic antidepressant agent. Neutropenia is an unusual but well-known complication of the use of tricyclic antidepressant agents,<sup>1</sup>but, to our knowledge, this complication has not been reported with the use of maprotiline. We present the case of a patient in whom neutropenia seems to be related to the use of this agent. <h3>Report of a Case</h3> A 51-year-old woman had been given maprotiline in early 1981 for severe depression that required hospitalization. Her condition was stabilized, and the drug therapy was continued at a dosage of 150 mg/day. Her only other medication was thyroid extract at a dosage of 6.2 g/day for hypothyroidism. In September 1981, the patient saw her dentist for aphthous ulcerations and was treated with unknown topical therapy, with resolution. In early November, the patient had the onset of pharyngitis and was given erythromycin stearate, 250 mg four times a day,
Numeric Error in Abstract
Authors: Marianthi-Anna Kioumourtzoglou, Marc Weisskopf
Journal: JAMA Pediatrics (2018)

Carl-Gustaf Bornehag, PhD; Christian Lindh, PhD; Abraham Reichenberg, PhD; Sverre Wikström, PhD; Maria Unenge Hallerback, PhD; Sarah F. Evans, PhD; Sheela Sathyanarayana, MD; Emily S. Barrett, PhD; Ruby H. N. Nguyen, PhD; Nicole R. Bush, PhD; Shanna H. Swan, PhD
Increasing the completion of the durable power of attorney for health care. A randomized, controlled trial
Authors: S. M. Rubin
Journal: JAMA (1994)

<h3>Objective.</h3> —Wider use of written advance directives may prevent many ethical dilemmas about life-sustaining interventions for patients who have lost decision-making capacity. We investigated whether a simple educational intervention increased patient completion of the durable power of attorney for health care. <h3>Design.</h3> —A randomized, controlled trial. <h3>Setting.</h3> —A health maintenance organization. <h3>Subjects.</h3> —All patients aged 65 years and older and discharged from a hospital between January 1991 and May 1991 (n=1101) were randomized to either an intervention group or a control group. <h3>Intervention.</h3> —An educational pamphlet on the durable power of attorney for health care and a durable power of attorney for health care form were mailed to all patients in the intervention group. The control group received conventional care only. <h3>Main Outcome Measure.</h3> —Completion of the durable power of attorney for health care form. <h3>Results.</h3> —There were no significant baseline differences between the intervention group and the control group. Following our intervention, 18.5% of the subjects in the experimental group completed a durable power of attorney for health care form, compared with 0.4% of the control group (<i>P</i>&lt;.0001). <h3>Conclusions.</h3> —A simple educational intervention significantly increased the completion of the durable power of attorney for health care. Our findings should stimulate further efforts to empower patients to make informed decisions about their health care. (<i>JAMA</i>. 1994;271:209-212)
THE PROTOZOON OF CANCER.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXCELSIOR
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
War Wounds
Authors: Edwin J. Pulaski
Journal: New England Journal of Medicine (1953)

Care of Specific War Wounds Arteries.35 The successful primary repair of wounds of major peripheral arteries represents the most significant advance in the care of the wounded that has occurred in the Korean conflict. Some patients with wounds of major arteries in the body cavities do not survive long enough to receive treatment; however, this is not so in the periphery, where the surrounding tissues limit the amount of blood that is lost. In a recent series in Korea, Jahnke and Seeley35 reported only 1 early anastomotic failure in the repair of 33 consecutive major peripheral arterial injuries. The . . .
VISUAL ERRORS AND AUTOMOBILE ACCIDENTS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Public Health Consequences of Heavy Metals in Dump Sites
Authors: Thomas W. Clarkson, Bernard Weiss, Christopher Cox
Journal: Environmental Health Perspectives (1983)

Metals differ from most synthetic organic chemicals in that their clinical manifestations are well known and methods for their measurement in the body are generally well established. Since metals are ubiquitous, special care should be taken to identify the source, whether dump site or not. Isotopic ratios may be used for lead. Time of exposure may be highly variable so estimates will be necessary of integrated "dose-commitment." Transmission to man will follow many pathways. The contamination of children's hands and clothing by dust may be an important route. Because effects are so different, the chemical species (e.g., organic versus inorganic forms) of each metal must be identified. Exposure assessment requires identification of suitable indicator media, usually blood in the case of lead, urine with cadmium and inorganic mercury, and blood or hair with regard to methylmercury. Human head hair may have considerable potential, as it may provide a recapitulation of past exposures. The first health complaints associated with most metals are usually nonspecific. The complex social, political, and legal issues strongly indicate the need for objective tests for health effects. Most important is the identification and measurement of the critical effect, i.e., an effect that alerts the public health authorities that further exposure should cease. For example, in the case of lead, the critical effect is hematologic; with cadmium it is the presence in urine of abnormally high concentration of small molecular weight protein; and with mercury no early objective test has yet been devised.
High-Dose Statins in Acute Coronary Syndromes: Not Just Lipid Levels—Correction
Authors: Albert Zink, Stephanie Panzer, Martinus Fesq-Martin, Eva Burger-Heinrich, Joachim Wahl, Andreas Nerlich
Journal: JAMA (2005)

nial vault.The histological appearance of enhanced endosteal resorption with tunneling osteoclasia is considered virtually pathognomonic for primary hyperparathyroidism. 5 Parathyroid adenoma causes 90% of primary hyperparathyroidism.The incidence of this disease in current populations is about 30 per 100000, with untreated mortality of approximately 20%.Assuming an ancient population of only a few million individuals in Central Europe 7 and a low frequency of investigated skeletons from that period, the lack of iden-tified cases is not surprising.Our observations suggest that this disease was already present in one of the earliest farming populations of Central Europe.