tbuckley/cabot-search huggingface dataset:
International Accreditation
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WEATHER AND DISEASE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GLP-1 gene delivery for the treatment of type 2 diabetes
Authors: Seungjoon Oh, Minhyung Lee, Kyung Soo Ko, Suna Choi, Sung Wan Kim
Journal: Molecular Therapy (2003)

Glucagon-like peptide-1 (GLP-1) is a potent insulinotrophic hormone, which makes GLP-1 an attractive candidate for the treatment of type 2 diabetes. However, the short plasma half-life of the active forms of GLP-1 poses an obstacle to the sustained delivery of this peptide. In this study, we evaluated the effect of GLP-1 gene delivery both in vitro and in vivo using a new plasmid constructed with a modified GLP-1 (7-37) cDNA. This cDNA contains a furin cleavage site between the start codon and the GLP-1 coding region. The expression of the GLP-1 gene was driven by a chicken beta-actin promoter (pbetaGLP1). The level of the GLP-1 mRNA was evaluated by RT-PCR 24 h after transfection. The in vitro results showed a dose-dependent expression of GLP-1. Coculture assay of the GLP-1 plasmid-transfected cells with isolated rat islet cells demonstrated that GLP-1 increased insulin secretion by twofold, compared to controls during a hyperglycemic challenge. A single injection of polyethyleneimine/pbetaGLP1 complex into ZDF rats resulted in increasing insulin secretion and decreasing blood glucose level that was maintained for 2 weeks. This GLP-1 gene delivery system may provide an effective and safe treatment modality for type 2 diabetes.
Quinidine Hepatotoxicity
Authors: James R. Dzur
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I was interested in a case report inThe Journal(234:310, 1975). About four months ago, we instituted quinidine therapy for a patient with multiple premature atrial contractions, and the arrhythmias were corrected. However, about one month after treatment began, jaundice developed. The patient's liver became enlarged, and his alkaline phosphatase, bilirubin, SGOT, and lactic dehydrogenase levels all became elevated. We therefore discontinued the use of quinidine, which was the only medication he was taking at the time, and over the next three weeks all liver function study findings returned to normal. Once again the liver was not palpable. We have not rechallenged this patient with quinidine, but it would appear that he also had quinidine-induced hepatitis. Therefore, I think this is probably another case to add to the cases already published, including the one reported inThe Journal.
Splenic rupture associated with bacterial endocarditis and sickle cell trait
Authors: J. M. Baron
Journal: JAMA (1968)

A patient with bacterial endocarditis and sickle cell trait survived septic rupture of the spleen. This is the third reported case of survival following this rare complication of endocarditis. Certain features permitted early suspicion of the complication and the favorable outcome is attributed to prompt operation followed by prolonged therapy with antibiotics for the endocarditis. Of key importance is the early diagnosis based upon the awareness of the frequent association of a significant pathological condition in the spleen and bacterial endocarditis.
Alzheimer Plaques
Authors: Tracy Hampton
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: M. J. BOROWITZ
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article BOOK REVIEWS Get access Lymph Node Pathology, 2nd Edition Harry L. loachim . Philadelphia : J. B. Lippincott , 1994 . 707 pp., illus. $169. ISBN 0-397-50807-7 MICHAEL J. BOROWITZ, M.D., PH.D. MICHAEL J. BOROWITZ, M.D., PH.D. Department of Pathology Johns Hopkins Medical Institutions600 N. Wolfe St. Baltimore, MD 21287 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 11, 1 June 1994, Pages 862–863, https://doi.org/10.1093/jnci/86.11.862 Published: 01 June 1994
Hiatus hernia.
Journal: BMJ (1968)

member of a family to be affected.Recently, however, Jane Chatten and Mary L. Voorhess discovered neuroblastomas in three of four siblings."They then noted that the mother was pregnant and that during the sixth month of this pregnancy she was excreting large amounts of catecholamine in her urine.The child was delivered at term and five months later was found to have a mediastinal neuroblastoma.There were thus four siblings in the same family with neuroblastomas.One child had neuroblastoma in situ and aganglionosis of ileum and colon; the other three had overt neuroblastomas.Up to the time of this report there had been only four recorded instances of a second affected child in the same family.One of these cases was reported by J. Zimmermann,' who sug- gested the tumour was inherited as an autosomal dominant.
Contents: (Adv. Healthcare Mater. 11/2013)
Journal: Advanced Healthcare Materials (2013)

MicropatterningErica Ueda and Pavel A. Levkin present a simple method to produce precise micropatterns of hydrophobic liquids by using hydrophilichydrophobic substrates.On page 1425, these micropatterns are shown to possess long-term stability, excellent cell-repellency, no cytotoxicity, and higher efficiency than conventional PEG or superhydrophobic surfaces in controlling eukaryotic cell adhesion. Drug SolubilityOn page 1469, Johan Forsgren, Albert Mihranyan, and co-workers show how vaterite is used as a phase stabilizer of amorphous celecoxib, resulting in the increase of the apparent aqueous solubility of the substance.The presented results show promise for the use of vaterite to achieve enhanced bioavailability in new formulations of Type II BCS drugs.Advanced Energy Materials is the new must-have forum for all energy-related research.
Abstract 17107: Distribution of Anti-inflammatory Activity During Remodeling of High Density Lipoprotein: Studies With CSL112
Authors: Svetlana A Diditchenko, Alexei V Navdaev, Martin O Spycher, Samuel D Wright
Journal: Circulation (2015)

Elevated levels of circulating inflammatory markers predict an unfavorable cardiovascular outcome in acute coronary syndrome patients. CSL112 is human apolipoprotein A-I (apoA-I), reconstituted with phosphatidylcholine to form HDL particles suitable for infusion. Addition of CSL112 to stimulated human whole blood ex vivo strongly reduces pro-inflammatory cytokine production. Infusion of CSL112 into human subjects or addition to human plasma ex vivo causes remodeling of endogenous HDL. Similar remodeling occurs upon incubation of CSL112 with purified HDL3 and results in accumulation of three HDL species: enlarged HDL (HDL2), a smaller, dense species (HDL3c), and lipid-poor apoA-I (pre-β1 HDL). Study aim was to determine the anti-inflammatory activity of remodeled HDL species. CSL112 was incubated with HDL3 and the products of particle remodeling were purified by ultracentrifugation. The inhibitory effects on pro-inflammatory cytokine production were examined using human peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin-M (PHA-M) in vitro. Lipid-poor apoA-I, HDL3c as well as parent CSL112 exerted powerful inhibitory effects on secretion of pro-inflammatory mediators (&gt; 89.2% + 4.0% inhibition of TNF-α, IL-1β, IL-6 and Mip-1β); HDL3 and HDL2 were much less effective (&lt; 54.1% + 3.9% inhibition). The extent of inhibition correlated positively with induction of the transcription repressor ATF3, a negative regulator of pro-inflammatory cytokine production, with lipid-poor apoA-I and HDL3c inducing higher protein levels of ATF3 in PHA-stimulated PBMC compared to control medium, HDL3 or HDL2. Anti-inflammatory activity of the remodeled species also correlated with their ability to support cellular cholesterol efflux via the ABCA1 transporter: lipid-poor apoA-I and HDL3c were potent acceptors of cholesterol; HDL2 was inactive. The ability to generate HDL species with high cholesterol efflux and anti-inflammatory activity makes CSL112 a promising candidate for removing cholesterol and reducing inflammation in atherosclerotic plaque, thus reducing the high risk of early recurrent atherothrombotic events following acute MI (AMI). A Phase IIb trial (AEGIS-I; NCT02108262) of CSL112 in AMI patients is ongoing.
Hospital Cross-Infection and Dirty Walls
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tc-99m-IDA Hepatobiliary Imaging
Authors: J. R. STY, D. P. BABBITT, W. SQUIRES
Journal: Clinical Nuclear Medicine (1979)

The authors describe the scintigraphic appearance of a fractured liver using a Tc-99m-IDA derivative. Tc-99m- IDA imaging provides both functional and morphologic information which is necessary in evaluating biliary tract trauma.
Prosthetic Problems
Authors: Charles A. Sanders
Journal: New England Journal of Medicine (1969)

Since the first successful replacement of a mitral valve with a ball-valve prosthesis by Starr in September, 1960,1 valve replacement has become routine therapy for certain types of valvular heart disease. A host of prostheses have been introduced and tested, with the result that most surgeons now prefer the ball valve for aortic replacement and the ball valve or low-profile disk valve for mitral replacement. The latter prosthesis has the distinct advantage of not intruding appreciably into the left ventricular cavity during systole, thus avoiding the hazard of endocardial erosion or left ventricular outflow obstruction occasionally encountered with the larger . . .
P-277 A prospective, observational trial to assess the safety and efficacy of regorafenib in patients with metastatic colorectal cancer (mCRC) in routine clinical practice (CORRELATE)
Authors: Ducreux Michel, Falcone Alfredo, Cornelis J.A. Punt, Kobina Svetlana, O'Connor Juan Manuel, Cervantes Andres
Journal: Annals of Oncology (2016)
Incorrect Values in Text and Table 4
Journal: JAMA (2021)

Andrea C. Tricco, PhD; Sonia M. Thomas, MSc; Areti Angeliki Veroniki, PhD; Jemila S. Hamid, PhD; Elise Cogo, ND; Lisa Strifler, MSc; Paul A. Khan, PhD; Reid Robson, MSc; Kathryn M. Sibley, PhD; Heather MacDonald, MSc; John J. Riva, DC; Kednapa Thavorn, PhD; Charlotte Wilson, MSc; Jayna Holroyd-Leduc, MD; Gillian D. Kerr, MD; Fabio Feldman, PhD; Sumit R. Majumdar, MD; Susan B. Jaglal, PhD; Wing Hui, MSc; Sharon E. Straus, MD, MSc
ASTHMA IN CHILDREN
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intestinal Absorption — Aspects of Structure, Function and Disease of the Small-Intestine Mucosa
Authors: Leonard Laster, Franz J. Ingelfinger
Journal: New England Journal of Medicine (1961)

DURING its absorption by the small intestine a substance leaves the bowel lumen, traverses the epithelial lining, passes through the connective-tissue stroma of the lamina propria and enters terminal branches of vascular or lymphatic vessels. The structures that lie between the intestinal lumen and the intramural vessels undoubtedly participate in the regulation of absorption. Since their morphologic characteristics provide insight into their functional activities, a detailed consideration of these structures is warranted.The Intestinal MucosaExcept in the lower ileum, the mucosal surface of the small intestine is thrown into a series of folds that run obliquely across the bowel . . .
Institutionalization of patients with hip fractures
Authors: V. A. Portnoi
Journal: JAMA (1983)

<h3>In Reply.—</h3> We are grateful for the reference to an example of healing rheumatoid erosions after gold therapy. Published references documenting this phenomenon are difficult to find. Since our article reporting complete healing of erosions after use of combined remission-inducing agents, another report of healing erosions after synovectomy was brought to our attention by John Webb, MD, of the Royal North Shore Hospital, Sydney, Australia.<sup>1</sup>Since submission of our report, we have reviewed the roentgenograms of ten patients (personally treated) with RA who have been in complete remission and have found three additional examples of completely healed erosions; one of these patients had been treated with gold, another had received penicillamine, and the third, the combined drug program. These observations will be published as a separate report. We have reviewed the original films and their reproduction (Fig 7) and fail to see any new erosions.
Pathology of Tumours of the Nervous System
Authors: Orville T. Bailey
Journal: JAMA (1971)

When this book first appeared in 1959, it at once became established as the standard work in its field. A second edition in 1963 contained comparatively minor revisions. A new third edition, however, has extensive additions and some new features. The result is to lengthen the book by nearly 100 pages with consequent increase in price. Important additions are a brief discussion of experimental oncogenesis and all material currently available on the electronmicroscopic findings in tumors of the nervous system. Inclusion of the titles of references makes the bibliography much more easily used. The illustrations have been especially satisfactory from the beginning. They have been retained and 25 new ones added, the majority well-chosen electronmicrographs. Comparison shows that the reproduction of illustrations is significantly better in the new edition than in the second. The chapter by Lumsden on tissue culture in relation to tumors of the nervous system is well
Efficacy and safety of interferon alfa therapy in chronic hepatitis C with autoantibodies to liver-kidney microsomes
Authors: L TODROS
Journal: Hepatology (1995)

Interferon alfa (IFN) therapy is efficacious in chronic viral hepatitides. It may, however, cause adverse immunologic reactions in patients with concomitant autoimmune phenomena. A minority of patients with chronic type C hepatitis have antibodies against liver and kidney microsomes (anti-LKM) in serum. We therefore carried out this study to find out whether IFN is safe and efficacious also in this subgroup. We treated 92 consecutive cases of chronic hepatitis C with IFN. Twelve patients had anti-LKM, and the remaining 80 tested negative to the anti-LKM. The hepatitis C virus (HCV) infection was diagnosed on the basis of positive anti-HCV and HCV-RNA tests. We compared the clinical and virological results of the therapy and the side effects found in the two groups. We found that the response to therapy and the outcome after 1 year of follow-up were similar. Treatment was discontinued in one anti-LKM-positive patient because of a drastic increase in ALT levels at the fourth month of therapy. No untoward effect was observed in the other cases. Hepatitis C patients with anti-LKM may be exposed to an increased risk of an adverse hepatitic reaction while being treated with IFN. However, we found that the extent of the risk was minimal compared with the expected benefits of the therapy. IFN is therefore recommended as the first therapy to choose in these patients. They must, however, be monitored more closely for possible liver dysfunction than the ordinary hepatitis C patient. (Hepatology 1995; 22:1374–1378).
Breast cancer detection among Irish <i>BRCA1</i> and <i>BRCA2</i> mutation carriers.
Authors: Elaine Walsh, Michael P. Farrell, Fergal Gallagher, Roisin Clarke, Carmel Nolan, M. John Kennedy, Peter Daly, John McCaffrey, Elizabeth M. Connolly, Terence Boyle, Malcolm R. Kell, David J Gallagher
Journal: Journal of Clinical Oncology (2012)

59 Background: High-risk breast cancer screening for BRCA1/2 mutations carriers with clinical breast exam, mammography and MRI have sensitivities approaching 100%. Even with intensive screening BRCA mutation carriers can present with self-detected interval cancers. We investigate screening practices and presentation among a cohort of Irish BRCA1/2 mutation carriers. Methods: Females with breast cancer belonging to kindreds now known to harbour BRCA1/2 mutations were retrospectively identified. Records were reviewed for BRCA mutation, demographics, breast cancer diagnosis, stage, histology and screening. We assessed screening modalities and whether breast cancers were diagnosed at screening or as interval cancers. Results: 53 cases of breast cancer were diagnosed from 1968-2010 among 53 Irish hereditary breast ovarian cancer kindreds. BRCA mutation status was unknown at time of diagnosis but subsequently confirmed. Detection method was identified in 50% of patients: 84% by clinical breast exam (CBE), 4% mammography, 4% MRI and 8% by a combination of CBE and mammography. Fifteen women (28%) developed second breast cancer; 9(60%) were undergoing screening, 2 were not and 27% were unknown. 22% were detected by CBE alone; 34% mammography; 22% a combination of mammography and CBE and 22% by MRI. In 41%, histology changed between first and second diagnosis. Two women developed a third breast cancer. In one, her second was an interval cancer despite being in a screening programme. Her third was radiologically detected. Conclusions: In this cohort of Irish BRCA1/2 mutation carriers almost 25% of second breast cancers were not detected by screening. 4% of cases were phenocopies and in 41% histology changed between first and second diagnosis. [Table: see text]