Angiotensin-Converting Enzyme Inhibitors and Angiotensin-Receptor Blockers in Chronic Heart Failure
Authors: Michael J. Peeters, James P. Tsikouris
Journal: Annals of Internal Medicine (2005)

Letters1 March 2005Angiotensin-Converting Enzyme Inhibitors and Angiotensin-Receptor Blockers in Chronic Heart FailureMichael J. Peeters, PharmD and James P. Tsikouris, PharmDMichael J. Peeters, PharmDFrom Texas Tech University Health Sciences Center, Lubbock, TX 79430.Search for more papers by this author and James P. Tsikouris, PharmDFrom Texas Tech University Health Sciences Center, Lubbock, TX 79430.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-5-200503010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:It would be remiss not to draw attention to the dosing of the ACE inhibitors and ARBs in the article by Lee and colleagues (1). In recent ARB trials that were newly incorporated into Lee and colleagues' meta-analysis, much higher doses of ARBs were used than in previous trials. Earlier comparison trials showing trends toward superiority of ACE inhibitors over ARBs used routine doses of the former but lower doses of the latter (2, 3). When ACE inhibitors and ARBs are used in the higher doses examined more recently, ARBs appear to become a suitable alternative to ...References1. Lee VC, Rhew DC, Dylan M, Badamgarav E, Braunstein GD, Weingarten SR. Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarction. Ann Intern Med. 2004;141:693-704. [PMID: 15520426] LinkGoogle Scholar2. Pitt B, Poole-Wilson PA, Segal R, Martinez FA, Dickstein K, Camm AJ, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II. Lancet. 2000;355:1582-7. [PMID: 10821361] CrossrefMedlineGoogle Scholar3. Dickstein K, Kjekshus J. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan. Lancet. 2002;360:752-60. [PMID: 12241832] CrossrefMedlineGoogle Scholar4. McMurray JJ, Ostergren J, Swedberg K, Granger CB, Held P, Michelson EL, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003;362:767-71. [PMID: 13678869] CrossrefMedlineGoogle Scholar5. Pfeffer MA, McMurray JJ, Velazquez EJ, Rouleau JL, Kober L, Maggioni AP, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003;349:1893-906. [PMID: 14610160] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Texas Tech University Health Sciences Center, Lubbock, TX 79430. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: Angiotensin-Receptor Blockers in Chronic Heart Failure and High-Risk Acute Myocardial Infarction Victor C. Lee , David C. Rhew , Michelle Dylan , Enkhe Badamgarav , Glenn D. Braunstein , and Scott R. Weingarten Angiotensin-Converting Enzyme Inhibitors and Angiotensin-Receptor Blockers in Chronic Heart Failure Loren D. Regier and Brent Jensen Angiotensin-Converting Enzyme Inhibitors and Angiotensin-Receptor Blockers in Chronic Heart Failure Victor C. Lee , David C. Rhew , and Glenn D. Braunstein Angiotensin-Converting Enzyme Inhibitors and Angiotensin-Receptor Blockers in Chronic Heart Failure Mark B. McClellan , Jerod M. Loeb , Carolyn M. Clancy , Gary S. Francis , Alice K. Jacobs , Kenneth W. Kizer , Margaret E. O'Kane , and Michael J. Wolk Metrics 1 March 2005Volume 142, Issue 5Page: 388KeywordsACE inhibitorsHeart failureHypertensionMyocardial infarction ePublished: 1 March 2005 Issue Published: 1 March 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...