tbuckley/cabot-search huggingface dataset:
111. Locoregional Intravenous Delivery of AAV Vector in Macaque Results in Persistent Transgene Expression Despite a Dedicated Humoral and Cellular Immune Responses
Authors: Gwladys Gernoux, Marie Devaux, Laurence Dubreil, Nicolas Jaulin, Mickaël Guilbaud, Jack-Yves Deschamps, Thibaut T. Larcher, Lydie Guigand, Maeva Dutilleul, Caroline Le Guiner, Yan Cherel, Philippe Moullier, Oumeya Adjali
Journal: Molecular Therapy (2013)
Error in the Figure
Authors: Shiwei Liu, Yichong Li, Maigeng Zhou
Journal: JAMA Cardiology (2019)

Yuichiro Yano, MD, PhD; Rikki M. Tanner, PhD; Swati Sakhuja, MPH; Byron C. Jaeger, PhD; John N. Booth III, PhD; Marwah Abdalla, MD, MPH; Daniel Pugliese, MD, MSc; Samantha R. Seals, PhD; Gbenga Ogedegbe, MD, MPH; Daniel W. Jones, MD; Paul Muntner, PhD; Daichi Shimbo, MD
Middle-ear problems in childhood
Authors: F. W. Davison
Journal: JAMA (1966)

Before discussing some of the disease entities encountered in children, I would like to comment on methods of examination. If one is to have any concept of what is taking place in the middle ear, he must be able to visualize accurately the tympanic membrane. The best source of illumination is a head mirror or preferably a head light, which can be worn over one eye to provide axial illumination. Use of the head light leaves the examiner with two hands unencumbered, one to use the speculum with a magnifier ( ×2) attached and the other hand free to use a curette for removing wax or semisolid debris. If there is fluid exudate, it can be removed with a cotton-tipped applicator or preferably a No. 15 gauge aspirating tip if suction is available. The examiner should select the largest size speculum which will fit comfortably in the ear canal. The magnifier
A PROTEST
Authors: M. A. G. Forbes-Winslow
Journal: BMJ (1915)

<h3>Abstract</h3> Genomic imprinting is an epigenetic phenomenon by which certain genes display monoallelic expression in a parent-of-origin-dependent manner. Hundreds of imprinted genes have been identified from several plant species. Here we identified, with a high level of confidence, 208 imprinted candidates from rice. Imprinted genes of rice showed limited association to the transposable elements, which is contrast to the findings in <i>Arabidopsis</i>. Generally, imprinting of rice is conserved within species, but intraspecific variations were confirmed here. Imprinting between cultivated rice and wild rice are likely similar. The imprinted genes of rice do not show significant selective signatures overall, which suggests that domestication imposes limited evolutionary effects on genomic imprinting of rice. Though the conservation of imprinting in plants is limited, here we prove that some loci tend to be imprinted in different species. In addition, our results suggest that differential epigenetic regulation between parental alleles can be established either prior to or post-fertilization. The imprinted 24-nt small RNAs, but not the 21-nt ones, likely involve the regulation of imprinting in an opposite parental-allele targeting manner. Together, our findings suggest that regulation of imprinting can be very diverse, and genomic imprinting as well as imprinted genes have essential evolutionary and biological significance.
Sleep disorders
Authors: Emma Rourke, Kirstie N Anderson
Journal: BMJ (2014)

How to identify and manage common sleep problems “. . . sleep and watchfulness, both of them when immoderate constitute disease” Hippocrates c 400BC All medical students can doubtless relate to the immediate consequences of disturbed sleep.1 The average UK medical student, however, receives little or no training in sleep medicine,2 yet this vital physiological process will occupy a third of our adult lives and disrupted sleep has immediate and long term consequences on physical and mental health.3 In most Western societies, we live in a world of sleep restriction and shift working, with the average adult now sleeping an hour a night less compared with the turn of the century.4 This article will provide the tools to identify when someone presents with signs or symptoms associated with poor sleep, when to take a sleep history, and how to identify and manage common sleep disorders, which can be a cause of considerable morbidity in hospitals and in the community.5 Sleep disorders fall into one or more of four categories: hypersomnia, insomnia, circadian rhythm disorders, and parasomnias. Common evening and night time disorders also include restless legs syndrome and associated periodic limb movements of sleep. Screening questions often help to identify the sleep problem that you are dealing with (box 1). Thereafter, sleep problems are best characterised on the basis of a thorough history. A collateral history from the bed partner is often helpful to define any restless legs, sleepwalking or parasomnia, snoring, and breathing abnormalities. Discussing the patient’s ideas about sleep, any concerns they might have, and their expectations of normal sleep is often worth while. #### Box 1: Sleep history questions
A phase III study comparing concurrent gemcitabine (Gem) plus cisplatin (Cis) and radiation followed by adjuvant Gem plus Cis versus concurrent Cis and radiation in patients with stage IIB to IVA carcinoma of the cervix
Authors: A. Dueñas-González, J. J. Zarba, J. C. Alcedo, P. Pattarunataporn, S. Beslija, F. Patel, L. Casanova, H. Barraclough, M. Orlando
Journal: Journal of Clinical Oncology (2009)

CRA5507 Background: Cervical cancer is the second-most common cancer among women worldwide, in both incidence and mortality. Current standard therapy for locally advanced disease consists of concurrent Cis and external-beam radiation (XRT). This multicenter, open-label, randomized, phase III trial aimed to improve outcomes, capitalizing on the synergistic activity of Gem, Cis, XRT, and the potential value of adjuvant therapy. Methods: Eligible patients (pts) with bulky stage IIB to IVA, 18–70 years of age, chemotherapy- and radiotherapy-naive, with a Karnofsky Performance Status score ≥70, were randomized to Arm A: Cis 40 mg/m2 followed by Gem 125 mg/m2 weekly × 6 doses with concurrent XRT (50.4 Gy: in 28 fractions: 1.8 Gy/day, 5 days/week), followed by brachytherapy (brachy) (30–35 Gy) and then 2 adjuvant 21-day cycles of Gem (1,000 mg/m2 on Days 1 and 8) plus Cis (50 mg/m2 on Day 1); or Arm B: Cis 40 mg/m2 weekly × 6 doses with concurrent XRT followed by brachy, given as in Arm A. Primary endpoint was progression-free survival (PFS) at 3 years, compared between arms using Kaplan-Meier methods and a Z-statistic. Results: 515 pts were enrolled between 5/02 and 3/04 (259 pts Arm A, 256 pts Arm B). Median age was 46 years; stage IIB/IIIB/IVA in 61/37/2% of pts. Compliance in the concurrent and brachy phase was >90% for both arms; adjuvant cycles were completed by >75% of pts in Arm A. PFS at 3 years was 74% in Arm A compared to 65% in Arm B, resulting in a statistically significant improvement (p = 0.029). Overall survival (log-rank p = 0.0224) and time to progressive disease (log-rank p = 0.0008) were also significantly improved. Significantly more pts in Arm A experienced grade 3/4 toxicities (86.5%), compared to pts in Arm B (46.3%; Fisher's p < 0.001). In Arm A, 2 pts died due to causes probably related to treatment compared to 0 pts in Arm B. Conclusions: This novel regimen of concurrent Gem plus Cis and XRT followed by brachy and adjuvant Gem plus Cis significantly improved outcomes in pts with locally advanced carcinoma of the cervix, at the expense of increased but acceptable toxicity, compared to the current standard of care. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Eli Lilly and Company Eli Lilly and Company Eli Lilly
A phase lb study of oral panobinostat and IV bortezomib in relapsed or relapsed and refractory multiple myeloma.
Authors: J. F. San-Miguel, P. G. G. Richardson, O. Sezer, A. Guenther, D. S. D. Siegel, J. Blade, R. LeBlanc, H. J. Sutherland, M. Mateos, M. Gramatzki, K. M. Hazell, B. Bengoudifa, P. M. Bourquelot, K. C. Anderson
Journal: Journal of Clinical Oncology (2011)

8075 Background: Panobinostat (PAN) is an oral pan-deacetylase (DAC) inhibitor that demonstrates synergistic anti-myeloma activity in combination with bortezomib (BTZ) through dual inhibition of DACs and the proteasome. Methods: This phase Ib study of relapsed or relapsed and refractory (ref) multiple myeloma (MM) completed enrollment (N=62) in Dec 2010 with 47 patients (pts) in the dose escalation phase and 15 pts in the dose expansion phase. In the dose escalation phase PAN was dosed orally 3 times/week (wk) in combination with BTZ (IV Days 1, 4, 8, 11) in 21-day cycles (C). Dexamethasone (DEX) was added for suboptimal response from C2 onwards. MTD was determined to be 20 mg PAN + 1.3 mg/m2 BTZ. In the expansion phase, 15 pts received the MTD of PAN + BTZ, with a modified PAN schedule (2 wks on, 1 wk off) and DEX introduced for all pts at C2. This is identical to the dose and schedule in the ongoing phase II and III PANORAMA trials. Results: Pts in the dose-escalation phase received a median of 2 (1-10) prior therapies including 28 with prior BTZ. Responses of ≥MR were observed in 36/47 (76%) of pts (10/15 [66%] BTZ-ref) (Table). Response assessments are available to date for 12 pts in the dose-expansion phase with ≥ MR observed in 9/12 pts (75%) including 1/4 BTZ-ref pts. Common grade 3/4 AEs among 62 pts included: thrombocytopenia (n=47), neutropenia (n=33), asthenia (n=13), anemia (n=10), with no treatment-related mortality. Conclusions: The combination of PAN and BTZ has a predictable and manageable safety profile with promising activity in advanced MM including those pts with BTZ-ref MM. Updated data from the dose-expansion phase will be presented. Best response by cohort. Treatment phase Dose escalation (n= 47, 15 BTZ-ref) Dose expansion (n=15, 4 BTZ-ref) Cohort 1 2 3 4 5 6 7 PAN 10 mg 20 mg 20 mg 30 mg 25 mg 20 mg 20 mg (2 wks on, 1 wk off) BTZ 1.0 mg/m2 1.0 mg/m2 1.3 mg/m2 1.3 mg/m2 1.3 mg/m2 1.3 mg/m2 1.3 mg/m2 DEX * * * * * * 20 mg (from C2) Pts, nBTZ- ref, n 7 4 7 5 8 2 7 0 9 2 9 2 15 4 CR 1 0 2 0 1 0 2 0 VGPR 1 0 1 0 2 0 1 0 3 0 PR 3 3 2 1 4 0 6 2 4 0 6 1 MR 1 1 1 1 2 1 1 0 1 1 0 0 SD** 3 1 1 1 1 0 1 0 1 1 2 2 PD 1 1 1 1 NE 1 1 1 0 1 0 No data 3 0 Data cutoff as of 14 Jan 2011. * DEX was optional.** SD and MR pts listed separately.
Farmacologia
Authors: R. J. Main
Journal: JAMA (1962)

Offhand, there would appear few reasons for reviewing a Spanish pharmacology text here since few U.S. physicians will either have reason or sufficient knowledge of Spanish to consult it. However, because of the increasing number of interns from Spanish speaking countries coming to the United States, we may well be interested in knowing how their knowledge of this basic medical science compares to that of our students. It is obvious that students who have used Dr. Litter's text, have been exposed to a thorough and adequate textbook, that could be reduced in size by further shortening the discussion of such older drugs as valerian. The list of modern drugs is very complete, and the vast majority of references are to U.S. publications. The author is obviously a good teacher; the many tables that show side by side the structural formula; chemical, nonproprietary, and trademark names; and that give description and
Fulminant Myocarditis
Authors: Joel S. Karliner
Journal: New England Journal of Medicine (2000)

“Sick patients die” is a refrain familiar to all clinicians. It can easily be applied to patients with severe congestive heart failure or cardiogenic shock resulting from an acute inflammatory process involving the myocardium. In this issue of the Journal, McCarthy et al.1 suggest that the opposite may be true: the sickest patients (those with fulminant myocarditis), who constitute a clearly defined, small subgroup, are the most likely to make a full recovery. Such patients have a distinct onset of symptoms, with signs of cardiogenic shock or severe left ventricular dysfunction; they have multiple foci of active myocarditis, as shown . . .
Osmotic Diuresis
Authors: F.John Gennari, Jerome P. Kassirer
Journal: New England Journal of Medicine (1974)

IN recent years the widening application of osmotic diuretics in the practice of medicine has renewed interest in the physiologic effects of those agents. Mannitol is now prescribed in a wide variety of clinical settings, including drug intoxications, refractory edema, oliguric renal failure, and cerebral edema. Although the therapeutic value of mannitol in these settings remains controversial, its effect on body-fluid composition and volume is predictable and its administration can have important clinical consequences. Similarly, the contrast materials now used extensively in angiographic procedures can invoke an osmotic diuresis and alter body composition. In addition, osmotic diuresis is recognized as . . .
A Surgeon With AIDS
Authors: Ban Mishu
Journal: JAMA (1990)

In January 1988, the media reported the identity of a surgeon who was recently diagnosed with the acquired immunodeficiency syndrome (AIDS). Concern about surgeon-to-patient transmission of human immunodeficiency virus (HIV) persisted despite reassurances from health authorities. Therefore, HIV antibody testing was offered to the surgeon's patients. We identified 2160 patients operated on since 1982; none had been reported to Tennessee's AIDS registry. A total of 264 had already died; none were reported to have died of AIDS or other HIV-related diseases. Of the 1896 patients remaining, we contacted 1652; 616 (37%) were tested. Only one (an intravenous drug user) was HIV antibody positive, and his medical history suggested that he may already have had AIDS at the time of his surgery. These results support the concept that the risks to patients operated on by HIV-infected surgeons are most likely quite low and support recommendations for the individualized assessment of HIV-infected health care workers. (<i>JAMA</i>1990;264:467-470)
Calcium carbonate in cholesterol gallstones: Polymorphism, distribution, and hypotheses about pathogenesis
Authors: Donald R. Taylor, Roger S. Crowther, John C. Cozart, Pamela Sharrock, Jinguang Wu, Roger D. Soloway
Journal: Hepatology (1995)

This study of sets of cholesterol gallstones collected consecutively from 222 patients in La Paz, Bolivia, and Mexico City, Mexico, has developed a reliable infrared (IR) spectroscopic method for the detection of calcium carbonate in cholesterol gallstones and provided the basis for simultaneous identification of each of its three polymorphs: calcite, vaterite, and aragonite. The peaks in the 854 to 876 cm −1 region demonstrated 98% sensitivity and specificity for carbonate detection. As little as 3% carbonate by weight could be detected using these peaks. The overall incidence of carbonate was 19% in these populations containing a high proportion of Amerinds. Infrared microspectroscopy of 10 to 50 μm particles, dissected from stones, allowed a ring-by-ring examination of 11 carbonate-containing stones. It was determined that different carbonate polymorphs, when present in the same gallstone, almost always occurred in separate rings. In approximately half of the gallstones, different polymorphs were present in successive layers in the same stone, indicating that conditions governing stone growth changed cyclically. Carbonates were usually precipitated in peripheral layers rather than in the center, supporting the theory that formation of calcium carbonates may be related to episodes of intermittent obstruction of the cystic duct, as opposed to being a major factor in stone nidation. (Hepatology 1995;22:488-496.)
Journal Jubilee
Authors: S. S. B. GILDER
Journal: Annals of Internal Medicine (1976)

Abroad1 December 1976Journal JubileeS. S. B. GILDER, M.D.S. S. B. GILDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-6-824 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty-five years is a ridiculously small time span under the mirror of eternity, but it is still quite a long time in the history of a medical journal. So perhaps the South African Medical Journal is justified in making something of its 25th Jubilee and publishing a special issue with a selection of outstanding articles that have appeared in its pages (S Afr Med J 6 March 1976).National medical journals have both a local and a global responsibility, as Dr. Swinscow points out in an editorial. Some of the articles reprinted are primarily of local interest, such as the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1976Volume 85, Issue 6Page: 824-825 ePublished: 1 December 2008 Issue Published: 1 December 1976 PDF downloadLoading ...
Cryofibrinogenemia
Authors: John M. Kalbfleisch, Robert M. Bird
Journal: New England Journal of Medicine (1960)

THERE is recent evidence that the clinical paradox of a hemorrhagic diathesis simultaneously associated with intravascular thromboses can be accompanied by the development of qualitative changes in plasma proteins. Occasionally, such a bleeding tendency accompanied by intravascular thromboses has been attributed to a cryoglobulin.2 , 3 The prefix "cryo" designates a protein moiety that will precipitate in the cold but will redissolve when warmed. In 1955 Korst and Kratochvil4 reported another abnormal plasma protein that was associated with intravascular thromboses. This protein was clottable and had many other physical and chemical properties similar to fibrinogen, and it also exhibited the property of . . .
BOOK REVIEWS
Authors: E. E. VOKES
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Carcinomas of the Head and Neck: Cancer Treatment Research . Charlotte Jacobs , ed. William J. McGuire series ed. Dordrecht, The Netherlands : Kluwer Academic Publishers , 1990 , 291 pp, $125. EVERETT E. VOKES EVERETT E. VOKES Director of Clinical Research Development, Section of Hematology/Oncology Department of Medicine, University of Chicago Medical Center5841 South Maryland Ave., Box 420 Chicago, IL 60637 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 11, 5 June 1991, Pages 785–786, https://doi.org/10.1093/jnci/83.11.785-a Published: 05 June 1991
Act Fast and Think Sepsis
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigating Hypertension
Authors: M. J. Chamberlain, J. A. Gleeson
Journal: BMJ (1967)

MEDcJOURN 495 quite common with premedication and seda- tion techniques preceding local or regional anaesthesia.Having recently studied 10 routine dissections and carried out two special dissections, I am very aware that both large and small vessels are readily available for puncture where a needle may be inserted to block the inferior dental nerve.In consequence, I shall never give another inferior dental block injection without an aspirating syringe.It seems difficult to believe that this pro- gressive trismus in three or four days can be due to "organization of a band of fibrous tissue "-maybe it is hydrostasis, and aspira- tion under general anaesthesia in one of their patients might be very interesting.Several authors have described this com- plication,'" but the most fascinating article is that by John Campbell.'This is a careful account and discussion by an astute dentist of his own affliction: "At the end of the sixth week the first signs of remission came.. .I reacted philosophically to the inci- dent."Little wonder that Killey and Kay get so many of these cases-even John Campbell might have taken " the dreary road to the south."-Iam, etc.,
Bone Lead, Hypertension, and Lead Nephropathy
Authors: Richard P. Wedeen
Journal: Environmental Health Perspectives (1988)

There is considerable clinical evidence that excessive lead absorption causes renal failure with hypertension and predisposes individuals to hypertension even in the absence of detectable renal failure. Recent analyses of transiliac bone biopsies indicate that unsuspected elevated bone leads may reflect the cause (or contributing cause) of end-stage renal disease in 5% of the European dialysis population. In these patients, bone lead levels were four times higher than in unexposed cadavers (6 micrograms/g wet weight) and approximated levels found in lead workers (30 micrograms/g). At present, the most reliable index of the body lead burden is the CaNa2 EDTA lead mobilization test. In vivo tibial X-ray-induced X-ray fluorescence (XRF) is a more practical noninvasive technique for assessing bone lead, which should find widespread application as a diagnostic tool and for epidemiologic studies.
ABSTRACTS
Authors: Tmi Oiomt, H Spaet, T Bothwehl, Africa Brittigham, Jacque Caen, I Chanarin, J Chatterjea, India Amoz, I Chernoff, Pietro Denicola, Ludvik Donner, A Erslev, Philadelphia Fudenberg, San Francisco, Katsuhiro Fukutake, Robert Goldstein, Ira Green, F Gunz, Victor Herbert, Susanna Hohlan, Ernst Jaff, # {233}, York City, Michel Jamra, Alan Johnson, Oliver Jones, Joseph Kassirsky, U Sven-Age, E Kowalski, E Loeliger, Cohn Macpherson, Georges Math, Bracha Ramot, Peter Reizenstein, Julian Schorr, Ralph Wallerstein, F Gunz, H At, E Beutler, M Baluda, Cyte Dacoren, E Sutherland, Fragility Sass, L Levy, J Hoiejl, # {237}, L Mir, F Oski, I Naiman, Erythrocytes Cohen, P Hochstein, A Hill, A Haut, C Cartwriglut, M Wintrobe, T.-C Lee, L.-Y Shilu, P.-C Huang, C-C Lin, B-N Blackweil, S Ghose, A Chown, S Banerjiee, B Anderson, B10 Banerjee, G Stdhlberg, D Banerfee, S Apte, G Knight, A Nagamats'u, Mitsuko Watanabe, Yuichi Yarnamura
Journal: Blood (1964)