tbuckley/cabot-search huggingface dataset:
Plastic Isolator for Operating in a Sterile Environment
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two different mutations in codon 97 of the β‐globin gene cause Hb Malmö in Sweden
Authors: Britta Landin, Stig Berglund, Kristina Wallman
Journal: American Journal of Hematology (1996)

An abnormal hemoglobin with increased oxygen affinlty, Hb Maim6 [a,p297(FG4)His-Gln], was found to cause erythrocytosis In two apparently unrelated Swedish families.Direct nucieotide sequencing of amplitled DNA demonstrated a CACXAA substitutlon In one family and a CAC-CAG substitution in the other.Both mutations resulted in a Hls-Gin Substitution In codon 97.This finding prompted us to examlne the possible point mutations underlying the different hemoglobin variants reported In the Ilterature.
YELLOW FEVER.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute respiratory distress syndrome
Authors: Susannah K Leaver, Timothy W Evans
Journal: BMJ (2007)

#### Summary points Acute respiratory distress syndrome is the extreme manifestation of acute lung injury. Both these conditions complicate many medical and surgical conditions, not all of which affect the lung directly and are therefore encountered by clinicians working outside the critical care setting with varying frequency. Early recognition is important in determining outcome, as prognosis is usually dependent partly on the nature and prompt management of the precipitating condition. Acute lung injury and acute respiratory distress syndrome are defined by refractory hypoxaemia (using the PaO2 to FiO2 ratio) in association with bilateral lung infiltrates on chest radiography, in the absence of left atrial hypertension (thereby excluding hydrostatic pulmonary oedema as a cause) but in the presence of a clinical condition known to precipitate the syndrome (box 1). #### Box 1 Definition criteria for acute lung injury and acute respiratory distress syndrome1 In the appropriate clinical setting with one or more recognised risk factors, three criteria are required:
HOUT-30. TUMOR TREATING FIELDS (TTFIELDS) IN COMBINATION WITH LOMUSTINE (CCNU) AND TEMOZOLOMIDE (TMZ) IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA (GBM)
Authors: Lazaros Lazaridis, Niklas Schäfer, Sied Kebir, Johannes Weller, Theophilos-Dimitrios Tzaridis, Björn Scheffler, Daniela Pierscianek, Christoph Kleinschnitz, Martin Stuschke, Ulrich Sure, Ulrich Herrlinger, Martin Glas
Journal: Neuro-Oncology (2018)

TTFields in combination with TMZ showed significant survival benefit for newly diagnosed glioblastoma patients in the EF-14 trial, compared to TMZ standard therapy; independent of MGMT-promotor methylation-status, age and performance status. Recently, the CeTeG trial (NOA-09) demonstrated improved efficacy of lomustine (CCNU)/TMZ compared to TMZ standard therapy in newly diagnosed MGMT-promotor methylated GBM patients. Given that TTFields demonstrated a strong safety profile as well as a high potential being combined with other modalities and the very promising results for GBM patients with methylated MGMT-promotor in the CeTeG trial, there is a strong rationale in combining these modalities. This is the first report on patients, treated with a combination of both treatment regimens, TTFields and CCNU/TMZ. Patients with newly diagnosed GBM and MGMT-promoter methylation were treated after surgery and radiochemotherapy with a combination of TTFields plus CCNU/TMZ at our institutions. Patients with complete resection (N=4), partial resection (N=3) as well as biopsy (N=1) were included in the analysis. We assessed safety and feasibility of this combined therapy. Currently, eight patients (medians: age 49, [39–69]; KPS 90, [70–100]) have been treated and analyzed: GBM IDH mutant (N=2), IDH wild-type (N=6). To-date, CTCAE grade 3 hematotoxicities were observed in two patients, but were not considered to be related to the addition of TTFields to CCNU/TMZ. No further non-hematologic toxicity was observed. In one patient a grade 3 event (herpes zoster) emerged. Regarding medical device site reactions, low-grade skin irritations were detected in four patients (50%), corresponding to the safety analysis from the EF-14 trial with low-grade skin irritations in 52% of the patients. These data provide first indications that the combination of TTFields and CCNU/TMZ is probably safe and feasible. Additional follow-up and a higher sample size are needed for further toxicity analysis and efficacy assessment of this combination.
PRELIMINARY PROGRAM OF THE SCIENTIFIC ASSEMBLY
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Ethics
Authors: Robert M. Veatch
Journal: JAMA (1984)

Developments in medical ethics in the past year imply that an important shift is taking place. While once the critical controversies in medical ethics dealt with personal problems faced by patients or health professionals, the ethics of medicine must now be essentially social. The central and controversial issues involve complex social, political, and economic relationships and the increasing lay involvement in medical-ethical decision making. In March 1983, the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research issued its final reports.<sup>1</sup>The commission, an interdisciplinary body that included representation from the fields of medicine, nursing, sociology, law, and ethics and from the lay population, has now completed the first major systematic public assessment of the social and ethical policies affecting medical decision making in our society. That same month, it issued what was probably the most important of its reports—the comprehensive, authoritative assessment
Incorrect Word Affecting Meaning of Sentence
Journal: JAMA (2019)

US Preventive Services Task Force; Douglas K. Owens, MD, MS; Karina W. Davidson, PhD, MASc; Alex H. Krist, MD, MPH; Michael J. Barry, MD; Michael Cabana, MD, MA, MPH; Aaron B. Caughey, MD, PhD; Chyke A. Doubeni, MD, MPH; John W. Epling Jr, MD, MSEd; Martha Kubik, PhD, RN; C. Seth Landefeld, MD; Carol M. Mangione, MD, MSPH; Lori Pbert, PhD; Michael Silverstein, MD, MPH; Melissa A. Simon, MD, MPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD
The legacy of Homer W. Smith: mechanistic insights into renal physiology
Authors: L. G. Navar
Journal: Journal of Clinical Investigation (2004)

In 1945, Homer W. Smith published an article in the JCI that clearly demonstrated that para-aminohippuric acid is the most suitable agent for the evaluation of renal plasma flow in both humans and dogs; in addition, the paper provided detailed methodology that is still in use today. This paper is but one of many outstanding works performed by Smith and his colleagues that clearly established the clearance technique as a powerful noninvasive approach to gain mechanistic insights into intrarenal function.
Les arythmies en clinique.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4289: Targeting of phosphatidylserine by monoclonal antibodies enhances the activity of immune checkpoint inhibitors in breast tumors
Authors: Jian Gong, Shen Yin, Van Nguyen, Jeff Hutchins, Bruce D. Freimark
Journal: Cancer Research (2015)

Abstract Phosphatidylserine (PS) is a phospholipid normally residing in the inner leaflet of the plasma membrane that becomes exposed on tumor vascular endothelial cells (ECs) and tumor cells. PS exposure becomes enhanced in response to chemotherapy, irradiation, and oxidative stresses in the tumor microenvironment. PS exposure in tumors promotes an immunosuppressive microenvironment which includes the recruitment of myeloid derived suppressor cells (MDSCs), immature dendritic cells and M2-like macrophages, as well as, the production of anti-inflammatory cytokines. Binding of PS targeting antibodies on tumor endothelial cells, tumor cells and their secreted microparticles triggers an Fc-FcR mediated pro-inflammatory cellular and cytokine response that reverses the immunosuppressive PS meditated checkpoint, thereby enhancing anti-tumor immunity. A chimeric PS-targeting antibody, bavituximab, is being used in combination with chemotherapy to treat patients with solid tumors in multiple late-stage clinical trials. Using breast tumors in immune competent mice, we demonstrate PS targeting antibodies enhance the anti-tumor activity of combination therapies including anti-PD-1 antibodies. Tumor growth inhibition correlates with statistically significant increases in the infiltration of CD8+ T cells and a reduction of myeloid-derived suppressor cells (MDSCs). The combination of these mechanisms promotes strong, localized, anti-tumor responses without the side-effects of systemic immune activation. Citation Format: Jian Gong, Shen Yin, Van Nguyen, Jeff Hutchins, Bruce D. Freimark. Targeting of phosphatidylserine by monoclonal antibodies enhances the activity of immune checkpoint inhibitors in breast tumors. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4289. doi:10.1158/1538-7445.AM2015-4289
Correction
Journal: Circulation (2009)

Figure.En face photographs show distribution of regenerated endothelial cells on allografts.a, Photograph of aortic segment from TIE2-LacZ mouse that served as recipient.Balb/c vein segments were grafted into TIE2-LacZ mice and harvested 1 week after surgery.After ␤-gal staining and en face preparation, positive endothelial cells of allograft near the end (b) and the center (c) were compared.Arrows indicate examples of positive cells.
Actinic Rays.
Authors: A. Rose
Journal: JAMA (1904)

The Health of London.The report of Dr. S. F. Murphy, health Officer to the county council for 1902, has just been issued.A most grati¬ fying feature of the report is that, thanks to the untiring efforts of the Public Health Committee, London becomes more healthy year by year.The death rate for 1902 Avas only 17.2 per 1,000-the loAvest on record except that for 1901, Avhich was 17.1.The birth rate continues to steadily decrease, that for 1902 being 28.5-the loAvest on record.
FROM THE FDA
Authors: Stuart Nightingale
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acta Dermato-Venereologica, Stockholm
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reducing cholesterol levels in elderly persons
Authors: Carlos Brotons
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Drs Benfante and Reed<sup>1</sup>reported that serum cholesterol level is an independent predictor of coronary heart disease even among men older than 65 years, based on relative risk measures. This finding contrasts with reports from the Framingham study<sup>2</sup>and the Multiple Risk Factor Intervention Trial<sup>3</sup>that the effect of total serum cholesterol level diminishes with age and is not related to coronary heart disease in men studied after the age of 65 years. Several differences in methodology between those studies may have led to differences in the relationship between risk factor measurements and disease outcomes. Whatever is true, I think that in terms of prevention and possible intervention in clinical practice it is better to use the attributable risk or, as has been suggested,<sup>4</sup>the practical attributable risk. The number of deaths or myocardial infarctions that might be prevented by a particular
Style
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency Medicine
Authors: Louis S. Binder
Journal: JAMA (1993)

Research in basic and advanced cardiac life support (ACLS) continues to be one of the most important areas in emergency medicine for investigation and clinical progress. Preliminary studies suggested increased myocardial and cerebral blood flow, an improved balance between myocardial oxygen supply and demand, and improved rates of survival when larger doses (0.2 mg/kg) of epinephrine, compared with standard doses (0.01 to 0.02 mg/kg), were used in studies of cardiac arrest. Several case reports of survival after administration of high-dose epinephrine (HDE) have appeared in the literature. In 1992, three rigorous, large-scale clinical trials comparing survival from cardiac arrest managed with HDE vs standard-dose epinephrine (SDE) were reported. Stiell et al<sup>1</sup>reported the outcomes of 650 patients who were randomized to receive either HDE (7 mg) or SDE (1 mg) for up to five doses while undergoing otherwise standard ACLS protocols in the resuscitation of cardiac arrest (ventricular fibrillation,
Toxoplasmosis
Authors: Harry A. Feldman
Journal: New England Journal of Medicine (1968)

EpidemiologyThat toxoplasma infections occur almost throughout the world, but to different degrees in different places, has been well established. The illustrative personal data36, 54 55 56 summarized in Table 1 demonstrate very clearly the variable dye-test-positive rates to be expected in population studies. Similar information has been accumulated by others. Desmonts et al.47 found that 93 per cent of Parisian mothers who preferred undercooked or raw meat had dye-test antibodies, and at least 50 per cent of children less than seven years of age were reactors. These results are quite similar to those that we obtained in serums from Tahitians,54 whose cooking habits may . . .
p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts
Authors: F Furukawa
Journal: Hepatology (2003)

Hepatic stellate cells (HSCs) spontaneously transdifferentiate into myofibroblast (MFB)-phenotype on plastic dishes. This response recapitulates the features of activation in vivo. Transforming growth factor beta (TGF-beta) plays a prominent role in stimulating liver fibrogenesis by MFBs. In quiescent HSCs, TGF-beta signaling involves TGF-beta type I receptor (TbetaRI)-mediated phosphorylation of serine residues within the conserved SSXS motif at the C-terminus of Smad2 and Smad3. The middle linker regions of Smad2 and Smad3 also are phosphorylated by mitogen-activated protein kinase (MAPK). This study elucidates the change of Smad3-mediated signals during the transdifferentiation process. By using antibodies highly specific to the phosphorylated C-terminal region and the phosphorylated linker region of Smad3, we found that TGF-beta-dependent Smad3 phosphorylation at the C-terminal region decreased, but that the phosphorylation at the linker region increased in the process of transdifferentiation. TGF-beta activated the p38 MAPK pathway, further leading to Smad3 phosphorylation at the linker region in the cultured MFBs, irrespective of Smad2. The phosphorylation promoted hetero-complex formation and nuclear translocation of Smad3 and Smad4. Once combined with TbetaRI-phosphorylated Smad2, the Smad3 and Smad4 complex bound to plasminogen activator inhibitor-type I promoter could enhance the transcription. In addition, Smad3 phosphorylation mediated by the activated TbetaRI was impaired severely in MFBs during chronic liver injury, whereas Smad3 phosphorylation at the linker region was remarkably induced by p38 MAPK pathway. In conclusion, p38 MAPK-dependent Smad3 phosphorylation promoted extracellular matrix production in MFBs both in vitro and in vivo.