tbuckley/cabot-search huggingface dataset:
SUMMARY
Journal: American Journal of Psychiatry (1858)

These retrospective analyses represent a pilot study of a potential new outcome, expected emergence.The Behavior Rating Scale for Dementia (BRSD) was administered at the baseline and 12-month visits of a multicenter study.The authors computed the rates at which each BRSD symptom emerged over 12 months in normal elderly control subjects (n = 64).These normal rates were then applied as the expected emergent rate (EER) to a population of individuals with Alzheimer's disease (n = 235).The comparison of expected emergence to observed emergence in Alzheimer's disease showed interpretable differences.EER assesses whether treatments limit emergence in the target, relative to the standard, population.The ratio of expected to observed emergence provides an intuitively appealing quantification of treatment efficacy and can be used with any instrument that uses categorical or frequency ratings.
Molecular profiling of patients (pts) with advanced colorectal cancer (CRC): Princess Margaret Cancer Center experience.
Authors: Joanne Wing-Yan Chiu, Michael H. A. Roehrl, Stefano Serra, Monika K Krzyzanowska, Jennifer J. Knox, Helen Mackay, Hedley David, Malcolm Moore, Geoffrey Liu, Neesha C. Dhani, Suzanne Kamel-Reid, Emina Torlakovic, Tao Wang, Dianne Chadwick, Tong Zhang, Shingo Sakashita, Philippe L. Bedard, Eric Xueyu Chen, Ming Sound Tsao, Celeste Yu
Journal: Journal of Clinical Oncology (2014)

3572 Background: In routine clinical practice the prevalence of somatic mutations other than KRAS G12/13, PIK3CA, and BRAF in colorectal cancer (CRC) has not been well described. This study reports molecular profiling of pts with advanced CRC in clinical setting. Methods: Patients (pts) with advanced CRC are enrolled in an ongoing institution-wide screening program. Molecular profiling is performed on formalin-fixed and paraffin-embedded (FFPE) archival tissues using a customized Sequenom panel (23 genes, 279 mutations) or the Illumina MiSeq TruSeq Cancer Panel (48 genes, 212 amplicons, ≥500x coverage) in our Clinical Laboratory Improvement Amendments-certified laboratory. PTEN is determined by immunohistochemistry (IHC), with H score <1 defined as negative. Statistical analysis was performed with chi-square tests. Results: From March 2012 to October 2013, 190 pts were enrolled. At least one mutation was found in 55% (82/153) and 89% (33/37) of pts using Sequenom or MiSeq platforms respectively (p<0.01). Of all 190 pts, KRAS G12/13 mutation was identified in 35%, and non-G12/13 KRAS, BRAF, or NRAS mutations were present in 5% , 6%, and 4% respectively. Other mutations found included PIK3CA (13%, 24/190), CTNNB1, ERBB2, FGFR3, and EGFR (1% each). MiSeq detected additional mutations including KRAS A146 or L19F (4/37), SMAD4 (4/37), FRXW7 (3/37), APC (15/37), TP53 (26/37), ERBB4 (1/37), PTEN (1/37), and IDH1 (1/37). Co-mutation with KRAS was found in 63% of pts with PIK3CA mutation and 80% of pts with APC mutation. Of 85 pts with known PTEN IHC status, 19% were negative. A higher average number of mutations was observed in right- versus left-sided CRC (p<0.01). Mutations with known clinical significance (RAS and BRAF) were collectively more prevalent in right colon (p<0.01). Conclusions: Targeted next-generation DNA sequencing identifies more genomic alterations than SNP genotyping. Current strategy of anti-epidermal growth factor receptor therapy in KRAS G12/13 wild type pts might not benefit >15% of pts due to presence of other RAS/BRAF mutations. Clinically relevant genomic alterations are more likely to be detected in right colon.
Reaching for Medical Moons
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe hypertension. Treatment with minoxidil
Authors: P. K. Mehta
Journal: JAMA (1975)

Seventeen patients who were partially or totally refractory to maximal doses of conventional antihypertensive agents were treated with minoxidil. Three patients were receiving long-term maintenance dialysis. Propranolol and diuretics were given to prevent reflex tachycardia and fluid retention. Initial control of blood pressure was excellent in 16 patients. In one patient, diastolic blood pressure remained unchanged (120 mm Hg) despite 60 mg of minoxidil and volume depletion. In three other patients, secondary resistance developed, and the addition of guanethidine was necessary. The main side-effects were fluid retention (in eight) and hypertrichosis (in ten), accompanied in some by a peculiar coarsening of the facial features. Renal function stabilized or improved in most, and urine output increased in the three hemodialysis patients. We conclude that minoxidil is a valuable drug in severe hypertension. (<i>JAMA</i>233:249-252, 1975)
Transactions of the Michigan State Medical Society.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Analytical Biochemistry of Chromium
Authors: Sidney A. Katz
Journal: Environmental Health Perspectives (1991)

The essentiality and carcinogenicity of chromium depend on its chemical form. Oxidation state and solubility are particularly important in determining the biological effects of chromium compounds. For this reason, total chromium measurements are of little value in assessing its nutritional benefits or its toxicological hazards. Aqueous sodium carbonate-sodium hydroxide solutions have been successfully used for extracting hexavalent chromium from a variety of environmental and biological matrices while preserving its oxidation state. Typical recoveries are 90 to 105% in samples spiked with both trivalent and hexavalent chromium. Determination of hexavalent chromium after extraction with sodium carbonate-sodium hydroxide solution, coupled with the determination of total chromium after nitric acid-hydrogen peroxide digestion, has been applied to the evaluation of chromium speciation in airborne particulates, sludges, and biological tissues.
Aging--Causes and Defenses
Authors: G. Martin
Journal: Annual Review of Medicine (1993)

Recent studies have shown that chromosomes shorten as cells divide and become senescent. Also, deletions in mitochondrial DNA increase markedly with advancing age, presumably secondary to damage from oxygen radicals. Since host defenses against environmental factors also become attenuated, the molecular damage associated with aging may increasingly perturb normal homeostasis and increase the susceptibility to disease and disability. Such age-associated dysfunctions can be targeted and interrupted.
Human Sexuality, a Medico-Literary Treatise on the Laws. Anomalies, and Relations of Sex, with Especial Reference to Contrary Sexual Desire.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erosive spondylopathy.
Authors: C Courtois, G H Fallet, T L Vischer, P Wettstein
Journal: Annals of the Rheumatic Diseases (1980)

Seven patients with chronic dorsolumbar pain, stiffness and some restriction of spinal movements are described. Multiple lesions of the vertebral bodies were present. The lesions occurred at various levels and all had similar radiological characteristics, often returning to normal after several years. Vertebral changes of this type may be seen in patients with ankylosing spondylitis but for a variety of cogent reasons presented in this report our patients did not readily fall into this diagnostic group. The aetiology of these vertebral lesions is unknown but available evidence indicates that they should not be attributed to an infectious or neoplastic process.
Erectile dysfunction
Authors: A. Muneer, J. Kalsi, I. Nazareth, M. Arya
Journal: BMJ (2014)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Erectile dysfunction Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Access to Health Care
Authors: Richard H. Esham
Journal: Annals of Internal Medicine (1993)

Letters1 February 1993Access to Health CareRichard H. Esham, MD and Peter W. Morris, MDRichard H. Esham, MDSearch for more papers by this author and Peter W. Morris, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The undersigned are writing as individual internists, as ACP members, and as members of the Board of Censors of the Medical Association of the State of Alabama, by action of the Board on 16 September 1992.We appreciate the time and deliberations that went into the preparations of the ACP report. It describes the current situation eloquently and accurately in many details. However we disagree that the conclusions and recommendations derive from a consensus of the grass-roots membership of ACP or that “input from a network of 4500 ACP members” somehow constituted a general endorsement when these ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1993Volume 118, Issue 3Page: 232-235KeywordsDecision makingForecastingGlobal healthHealth careHealth care policyHeartPatientsTaxes ePublished: 15 August 2000 Issue Published: 1 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Isolating fetal cells from maternal blood. Advances in prenatal diagnosis through molecular technology
Authors: J. L. Simpson
Journal: JAMA (1993)

<h3>Objectives.</h3> —To review the rationale for and progress toward the goal of isolating and analyzing fetal cells circulating in maternal blood, and to explore the feasibility of this method in providing noninvasive prenatal cytogenetic diagnosis. <h3>Data Sources.</h3> —Critical review of data published since the first report (1969) of fetal metaphases in maternal blood. Emphasis is placed on data since the demonstration by polymerase chain reaction (PCR) in 1989 and 1990 that fetal cells indeed exist in maternal blood. <h3>Data Synthesis.</h3> —Clinical evaluations have not yet been conducted, but it is already clear that molecular technologies have allowed the unequivocal demonstration of fetal cells in maternal blood. Using PCR, our own group and others have demonstrated Y sequences and single gene sequences (eg, hemoglobin Lepore<sub>Boston</sub>) in maternal blood. Thus, fetal DNA sequences indeed exist in maternal blood. Among the various candidate cells, the most promising appear to be fetal nucleated red blood cells. We isolated nucleated red blood cells on the basis of flow-sorting for the transferrin receptor and glycophorin-A. Enriched samples were then subjected to fluorescence in situ hybridization with chromosome-specific probes. This approach allowed us to detect trisomy 21 and trisomy 18, work later confirmed by others. <h3>Conclusions.</h3> —Isolating and analyzing fetal cells from maternal blood is clearly possible. Several key biologic questions remain—the optimal cells for isolation, frequency of cells in maternal blood, timing during gestation for maternal blood sampling, and the likelihood of persistence of fetal cells after delivery. Clinical evaluations planned by the National Institute of Child Health and Human Development will determine the sensitivity and specificity of this method and its precise role in prenatal cytogenetic diagnosis. (<i>JAMA</i>. 1993;270:2357-2361)
'Type A' personalities in men 'mellowed' by beta blockers
Authors: J. Martin
Journal: JAMA (1982)

The use of β-blockers to treat hypertensive men can actually change type A personality behavior—itself a risk factor for coronary heart disease—toward type B, according to a group of West German physicians. The report was given at the recent American Psychosomatic Society meeting in Denver, where it attracted considerable interest. Investigators were Roland Schmieder, MD, Heinz Rüddel, MD, G. Friedrich, MD, and H. Neus, all of the Department of Medicine, University of Bonn. (Schmieder and Rüddel are currently at the Department of Preventive and Stress Medicine, University of Nebraska Medical Center, Omaha.) Type A temperament, the hard-charging sort of personality linked some years ago with heart disease, is characterized by several "stylistics," Rüddel told the meeting: loud and explosive speech, rapid and accelerated speaking, response latency, hostility, and verbal competition. About 70% of male hypertensive patients are type A, he said. They also manifest higher cholesterol and triglyceride levels and
More RIpH-Reply
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of gonorrhea. Comparison of penicillin G procaine, doxycycline, spectinomycin, and ampicillin
Authors: F. N. Judson
Journal: JAMA (1974)

Penicillin G procaine with probenecid, or doxycycline, or spectinomycin, or ampicillin with probenecid were used in the treatment of 1,238 men and women with gonorrhea. Of these, 718 returned for reculture. Recurrences of this disease in men as demonstrated by positive culture were as follows: after penicillin G procaine with probenecid therapy, 10%; doxycycline, 15%; spectinomycin, 10%; and ampicillin with probenecid, 10%. Recurrences in women were 1%, 4%, 2%, and 5%, respectively. Most recurrences in men were probably caused by reinfection. Comparison of strains isolated during 1971 with strains from 1973 did not indicate a trend toward increasing resistance. A strong correlation between resistance to penicillin G procaine and resistance to doxycycline and spectinomycin was shown for 83 randomly selected strains. (<i>JAMA</i>230:705-708, 1974)
Botulism: Still a Tragedy
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: JNCI Journal of the National Cancer Institute (1976)

In the Brief Communication “Detection and Estimation of Azomethane in Expired Air of 1,2-Dimethylhydrazine-Treated Rats” by Emerich S. Fiala, Callie Kulakis, George Bobotas, and John H. Weisburger, please note the following correction on page 1272: In the legend for text-figure 1, line 3 should read “… 21 (solid circles) or 200 mg 1,2-DMH-14C/kg (open circles) ….”
Perspectives on hepatitis B vaccination
Authors: Sr. Waisbren BA
Journal: JAMA (1997)

<h3>To the Editor.</h3> —I read with interest and appreciation the recent Landmark Perspective and the discussion regarding the hepatitis B vaccine by Dr Douglas.<sup>1</sup>However, I find it somewhat disturbing that Douglas did not mention the potential untoward results of viral vaccines, or those already reported as presumably being due to the hepatitis B vaccine. Douglas must be aware of the untoward results from the vaccine, not only because of lawsuits his company has settled in which demyelinating disease was involved, but also because of reports of adverse reactions linked to vaccine use in the medical literature,<sup>2-4</sup>including multiple sclerosis—like diseases, Guillain-Barré syndrome, optic neuritis, and transverse myelitis. Despite these reports, the strategy of universal vaccination in the United States has been promoted widely by Merck, the Centers for Disease Control and Prevention, and others.<sup>5,6</sup>Should not the parents of infants be made aware of the potential
The pediatric vaccine controversy: what should the doctor do?
Authors: A. R. Nelson
Journal: JAMA (1984)

When Senator Paula Hawkins (R, Fla) held hearings on her vaccine injury compensation bill (S. 2117) this summer, videotapes were shown that depicted children who had been injured by pediatric vaccines. The audience watching the video segment was visibly moved. Many may have been led to conclude that diphtheria-tetanus-pertussis (DTP) vaccination causes more problems than it solves. Some parents were bitter because state laws require administration of vaccines that (they allege) killed or maimed their child. Others were critical because their physician had not warned them of the risk of DTP immunization prior to administration. At the same hearing, other parents called for repeal of state laws that require immunization as a condition of entry into school. Vaccine manufacturers were criticized for failing to produce safer vaccines. Pediatricians testified that some of their colleagues are no longer administering vaccines because of concern about being sued (for failure to warn adequately
OCEANS: A randomized, double-blinded, placebo-controlled phase III trial of chemotherapy with or without bevacizumab (BEV) in patients with platinum-sensitive recurrent epithelial ovarian (EOC), primary peritoneal (PPC), or fallopian tube cancer (FTC).
Authors: C. Aghajanian, N. J. Finkler, T. Rutherford, D. A. Smith, J. Yi, H. Parmar, L. R. Nycum, M. A. Sovak
Journal: Journal of Clinical Oncology (2011)

LBA5007 The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed onsite at the Meeting on June 4, 2011, and as a supplement to the June 20, 2011, issue of Journal of Clinical Oncology.