tbuckley/cabot-search huggingface dataset:
Members of the House of Delegates
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P242: Carotid Plaque Characterization, Stenosis, and Intima-media Thickness According to Age and Gender in a Large Registry Cohort
Authors: Nancy M Boulos, Julius M Gardin, Shaista Malik, John Postley, Nathan D Wong
Journal: Circulation (2016)

Background: Carotid intima-media thickness (CIMT) is a well-established predictor of cardiovascular disease events. Not well described, however, is the prevalence of plaque and stenosis severity and how this varies according to extent of CIMT, age, and gender. Methods: We evaluated the extent of carotid plaque and stenosis severity according to CIMT, age and gender in a large CIMT screening registry. We studied 9347 women and 12676 men (n=22,023) who received carotid ultrasound scans. The presence and severity of both carotid plaque and stenosis was compared according to extent of CIMT ( &gt; 1 mm vs. &lt;1 mm), age, and gender using the Chi-square test of proportions. Results: Among those aged &lt;45 to &gt; 80 years the prevalence of CIMT &gt; 1 mm ranged from 0.13 to 29.3% in women and 0.6 to 40.1% in men, stenosis &gt;50% from 0.1% to 14.9% in women and 0.1% to 13.2% in men, and mixed/soft plaque from 7.1% to 66.5% in women and 9.2% to 65.8% in men (all p&lt;0.001 across age). While 6.6% of women and 8.5% of men with CIMT &lt;1mm had &gt;30% stenosis, this increased to 48.6% and 46.0%, respectively, in those with CIMT &gt; 1 mm. Even when CIMT levels were &lt;1 mm, &gt;30% of persons demonstrated mixed or soft plaque. Of those with CIMT &gt; 1mm, more than 70% had such mixed or soft plaque (Figure) and over 40% demonstrated stenoses of 30% or greater. Conclusions: We describe in a large CIMT registry study a substantial age-related increase in both men and women of CIMT, plaque presence and severity, as well as stenosis. Even in those with normal CIMT, mixed or soft plaque potentially prone to rupture was common, demonstrating the value in assessing for plaque when doing carotid ultrasound.
Employee rubella screening programs in Arizona hospitals
Authors: J. J. Sacks
Journal: JAMA (1983)

One year after voluntary guidelines on rubella screening of hospital employees were issued by the Arizona Department of Health, a survey of 68 members of the Arizona Hospital Association was conducted, with an 81% response. Some form of employee rubella screening was present in only 49% of responding hospitals. Of the screening hospitals, 70% of programs had a mandatory aspect for selected employees. Administrative logistics, cost, problems encountered, and the quality and coverage of the program varied substantially among the different hospitals. Fewer than half of the screening hospitals had programs for physicians, students, or volunteers. Verbal histories of immunization or serological tests, although notoriously unreliable, were accepted by 14% of the screening hospitals. Half of the nonscreening hospitals plan to implement programs in the future. Reasons given for not establishing rubella screening programs include cost, no pediatric or obstetric service, liability issues, high turnover, and no previous case of rubella in an employee. Three hospitals (all screening) reported they had had a case of rubella in an employee. The data suggest slow partial compliance with recommendations for rubella screening in hospitals. (<i>JAMA</i>1983;249:2675-2678)
Hyperinsulinemic hypoglycemia. Differential diagnosis by determination of the species of circulating insulin
Authors: W. A. Bauman
Journal: JAMA (1984)

Hypoglycemia when associated with hyperinsulinemia is usually a consequence of an insulinoma or the administration of either insulin or an insulin secretagogue. This report describes 14 patients with hypoglycemia whose diagnosis was clarified by the use of a species-specific insulin radioimmunoassay. Eleven of the 14 patients had elevated levels of animal insulin due to surreptitious accidental or malicious administration of insulin. Three of the 14 patients had hyperinsulinemia as the result of excessive human insulin release and were found to have either intrinsic pancreatic disease or secretagogue-mediated insulin release. (<i>JAMA</i>1984;252:2730-2734)
Cancer, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Abstracts
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Functional closure of the ventricular septal defect after pulmonary artery banding. An unusual late complication
Authors: K. Murthy
Journal: JAMA (1968)

A 9-week-old infant with a large ventricular septal defect (VSD) underwent successful banding of the pulmonary artery with clinical improvement. Spontaneous functional closure of the VSD later developed and, at age 4 1/2 years, the clinical and hemodynamic findings were those of severe isolated pulmonary stenosis with right ventricular failure. Severe right ventricular hypertrophy appearing late in the postoperative period should alert one of the possibility of a spontaneously closing VSD.
MANPOWER, LICENSURE, AND FOREIGN GRADUATES
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Streptococcal wound infections caused by a vaginal carrier
Authors: R. L. Berkelman
Journal: JAMA (1982)

During a four-month period, ten cases of group A streptococcal (GAS) postoperative wound infection occurred among patients in a community hospital. Bacteremia developed in two patients, and one patient died. Group A streptococcal surgical wound infections were associated with exposure to a circulating nurse and duration of surgery. Prophylactic antibiotics reduced the risk of infection. Vaginal, perineal, and anal cultures from nurse A yielded GAS, serotype M-4, T-4, as did the blood of two infected patients. Penicillin eradicated GAS colonization of nurse A, and she returned to work. Five months later, two additional cases of GAS postoperative wound infections occurred and were associated with recolonization of the same nurse with GAS, serotype M-nontypeable, T-12. She was relieved of patient-care duties, and no further cases have occurred. (<i>JAMA</i>1982;247:2680-2682)
Gonorrhea
Authors: ARNOLD L. SCHROETER
Journal: Annals of Internal Medicine (1970)

Diagnostic methods for Neisseria gonorrhoeae infections are surveyed with special emphasis on culturing on Thayer-Martin selective medium. The sensitivity and reproducibility of the culture method as well as suggestions regarding the optimal technique for obtaining and handling culture specimens are discussed. The problems of developing resistance to antibiotics are considered in the review of therapy. Current U.S. Public Health Service recommendations for diagnostic methods and treatment of N. gonorrhoeae infections are included.
Diabetic nephropathy. Clinical course in patients treated with the subcutaneous insulin pump
Authors: S. Cataland
Journal: JAMA (1983)

Twelve type I diabetic patients with established diabetic nephropathy were treated for 12 months with the insulin pump to determine whether glucoregulation would influence the clinical course of proteinuria. All of the subjects were known to have arterial hypertension and were receiving antihypertension medication. Despite good glucose control, as assessed by total glycosylated hemoglobin level, two clinical courses were observed: six patients demonstrated a progression in proteinuria and six appeared to experience a reduction in proteinuria. The group demonstrating a progession had significantly higher mean arterial pressure at six and 12 months of study compared with the group with a reduction in proteinuria. These results suggest that arterial hypertension is an important risk factor in the progression of diabetes nephropathy. Further studies should be designed to recognize early proteinuria and hypertension to determine whether mean normal glucose values and BP over a prolonged period will prevent renal failure. (<i>JAMA</i>1983;249:2059-2061)
ACC/AHA 2002 guideline update for the management of patients with unstable angina and non–ST-segment elevation myocardial infarction—summary article
Authors: Eugene Braunwald, Elliott M Antman, John W Beasley, Robert M Califf, Melvin D Cheitlin, Judith S Hochman, Robert H Jones, Dean Kereiakes, Joel Kupersmith, Thomas N Levin, Carl J Pepine, John W Schaeffer, Earl E Smith, David E Steward, Pierre Theroux, Raymond J Gibbons, Elliott M Antman, Joseph S Alpert, David P Faxon, Valentin Fuster, Gabriel Gregoratos, Loren F Hiratzka, Alice K Jacobs, Sidney C Smith
Journal: Journal of the American College of Cardiology (2002)
Hypertrophic cardiomyopathy
Authors: K. L. Baughman
Journal: JAMA (1992)

<h3>CASE PRESENTATION</h3> —<i>David Elliott, MD</i> A 53-YEAR-OLD white man with idiopathic hypertrophic cardiomyopathy underwent successful cardiac transplantation in August 1990. His medical history began in childhood when he first noticed decreased exercise tolerance and episodes of near syncope with exertion. He was first seen at Johns Hopkins in 1962, after he failed an army induction examination because of a cardiac murmur. Cardiac catheterization revealed a thick left ventricular wall with vigorous contractions causing near obliteration of the left ventricular cavity. The diagnosis of hypertrophic myopathy was established. The patient did well until 1968 when he presented with abdominal pain, orthopnea, and severe dyspnea on exertion. An electrocardiogram revealed new atrial fibrillation, with a ventricular response rate of 120 beats per minute, and Q waves in the inferior leads. The patient was given an anticoagulant, normal sinus rhythm was restored by cardioversion, and he was sent home with a prescription
Clinical Dialysis
Authors: Robert McCabe
Journal: JAMA (1985)

Over the past 20 years, the number of patients undergoing dialysis treatment has grown to over 66,000,10% of whom now use continuous ambulatory peritoneal dialysis (CAPD), a technique developed as recently as 1978. With such an expanding patient population and the minimal emphasis placed on the mechanical aspects of the life-sustaining procedures, the fellow in training has often neglected the sophisticated technical aspects of dialysis performed by nonphysician personnel. The editors of the now classic second edition of Brenner and Rector's<i>Nephrology</i>(WB Saunders Co, 1981) provide only anemic discussion on these complicated procedures in their last few chapters. Thus, the editors of<i>Clinical Dialysis</i>have filled a void by assembling a much needed text specifically dealing with the treatment of the patient with end-stage renal disease per se. They have used an impressive number of authorities with specialized interest in the patient with end-stage renal disease to report on
Hepatitis B virus (HBV) occult infection in subjects with persistent isolated anti-HBc reactivity
Authors: E. Lissen, A. Sánchez-Quijano, J.I. Jauregui, M. Leal, M.P. Civeira, J.A. Pineda, A. Castilla, F.García de Pesquera, J. Prieto
Journal: Journal of Hepatology (1991)
Biological Monitoring of Child Lead Exposure in the Czech Republic
Authors: Miroslav Cikrt, Zdenek Smerhovsky, Karel Blaha, Jana Nerudova, Viera Sediva, Helena Fornuskova, Jana Knotkova, Zdenek Roth, Miloslav Kodl, Edward Fitzgerald
Journal: Environmental Health Perspectives (1997)

The area around the Pribram lead smelter has been recognized to be heavily contaminated by lead (Pb). In the early 1970s, several episodes of livestock lead intoxication were reported in this area; thereafter, several epidemiological and ecological studies focused on exposure of children. In contrast to earlier studies, the recent investigation (1992-1994) revealed significantly lower exposure to lead. From 1986-1990, recorded average blood lead levels were about 37.2 micrograms lead (Pb)/100 ml in an elementary school population living in a neighborhood close to the smelter (within 3 km of the plant). The present study, however, has found mean blood lead levels of 11.35 micrograms/100 ml (95% CI = 9.32; 13.82) among a comparable group of children. In addition to blood lead, tooth lead was used to assess exposure among children. Statistically significant differences (p < 0.05) were observed between the geometric mean tooth lead level of 6.44 micrograms Pb/g (n = 13; 95% CI = 3.95; 10.50) in the most contaminated zone and 1.43 micrograms Pb/g (n = 35; 95% CI = 1.11; 1.84) in zones farther away from the point source. Both biomarkers, blood and tooth lead levels, reflect a similar pattern of lead exposure in children. This study has attempted a quantitative assessment of risk factors associated with elevated lead exposure in the Czech Republic. Content of lead in soil, residential distance from the smelter, consumption of locally grown vegetables or fruits, drinking water from local wells, the mother's educational level, cigarette consumption among family members, and the number of children in the family were factors positively related (p < 0.05) to blood lead levels. The resulting blood lead level was found to be inversely proportional to the child's age.
Reliability of cardiotocography in predicting baby's condition at birth
Authors: P Curzen, J S Bekir, D G McLintock
Journal: BMJ (1985)

Highlanders were also less likely than other respondents to report having consumed alcohol in the previous week.Levels of alcohol consumption-Table IV shows the mean levels of alcohol consumption reported by men and women in the three areas.Significant differences were reported in the mean amounts consumed during the previous week by both sexes in the three areas.Among men, those in Tayside drank the most; whereas among women, those in Kent were the heaviest drinkers.Highlanders drank the least.These differences did not appear to arise from either sampling or response bias (Crawford, and Crawford et al, unpublishedobservations).TABLE iv-Mean levels of self reported alcohol consumption (units*) among respondents who had consumed alcohol during previous week Area Respondents Level of significancef Highland Tayside Kent Men 15 4 19 1 16-9 Region:F=5 7;df=2,1407;p<0-003 Women 55 66 72 Sex: F=2185; df=1,1407; p<0001*Each unit equivalent to half pint (285 ml) ordinary beer, lager, etc, or single glass of wine or spirits.Each unit contains approximately 1 0 cl/7 9 g absolute alcohol.t3 (Area) x 2 (respondent's sex) analysis of variance with scores logged to base 10. ConclusionsThese results do not support the view that levels of alcohol consumption in the community mirror officially recorded rates of treated morbidity for alcohol dependence.In this respect this general population survey produced results fully compatible with those of our clinical survey.'Together these studies suggest that the widespread belief that alcohol dependence is vastly more commonplace in the north than in the south of Britain is more of a myth than a reality.Regional differences in other indicators of alcohol misuse remain to be explained.Several policy options exist whereby alcohol misuse may be curbed.These range from controlling the price and availability of alcohol to attempting to make public drinking more relaxed and socially integrated.Some of these are reviewed elsewhere.'3
Prospective study of human immunodeficiency virus infection and pregnancy outcomes in intravenous drug users
Authors: P. A. Selwyn
Journal: JAMA (1989)

To determine the effects of human immunodeficiency virus (HIV) infection on pregnancy outcomes, we prospectively studied female intravenous drug users in a methadone program in New York City. Of 191 women with HIV status known prior to pregnancy, 17 (24%) of 70 seropositives and 26 (22%) of 121 seronegatives became pregnant during 28 months of follow-up. Including 54 additional women first tested for HIV antibody after becoming pregnant, 125 pregnancies were studied in 97 women (39 seropositive, 58 seronegative). None of the seropositive pregnant women had advanced HIV-related disease at entry, and only one developed symptomatic disease (oral candidiasis) during pregnancy. No differences were observed between groups in the frequency of spontaneous or elective abortion, ectopic pregnancy, preterm delivery, stillbirth, or low-birth-weight births. Among women giving birth to live infants, seropositives were more likely than seronegatives to be hospitalized for bacterial pneumonia during pregnancy and had an increased tendency for breech presentation, although these events were infrequent. There were otherwise no differences between groups in the occurrence of antenatal, intrapartum, or neonatal complications. Results suggest that asymptomatic HIV infection is not associated with a decreased pregnancy rate or an increased risk of adverse pregnancy outcomes in intravenous drug users, and that an acceleration in HIV-disease status during pregnancy is uncommon. (<i>JAMA</i>. 1989;261:1289-1294)
Eurosurveillance reader satisfaction survey now online
Authors: Collective Eurosurveillance editorial team
Journal: Eurosurveillance (2010)

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Abstract 1722: Spectrum of solid malignancies associated with mutations in CYLD gene
Authors: Michelle Ellis, Jeff Swensen, Zoran Gatalica
Journal: Cancer Research (2019)

Abstract Introduction: The CYLD gene product is a de-ubiqutinating enzyme involved in regulation of NF-kappaB signaling. Inactivating germline mutations in CYLD are the cause of Brooke-Spiegler syndrome characterized by multiple cutaneous tumors (cylindromas, trichoepitheliomas and spiradenomas) and tumors of salivary glands. Little is known about the role of CYLD in the development of solid organ malignancies. Methods: We retrospectively analyzed CYLD gene mutations detected in a large database of solid tumors genetically profiled (NGS of 592 genes) at a reference laboratory (Caris Life Science, Phoenix, AZ). Results: CYLD pathogenic mutations were identified in 235 tumor samples (0.4% of the tumors analyzed). The most common primary sites included lung (60), endometrium (15) and anus (10). Histologically, the majority of the tumors were classified as squamous (71) and adenocarcinoma (59). A number of mutations were identified, most commonly affecting codons p.N722fs (27), p.S371* (16) and p.P771S/p.P771L (12). 38 cases had only CYLD mutations detected, while the majority of associated mutations occurred in TP53 (45%). Numerous co-occurring pathogenic mutations were present in oncogenes (e.g. PIK3CA in 41, KRAS in 33, BRAF 17) and/or tumor suppressor genes (e.g. APC in 40, PTEN in 36, BRCA2 in 25, RB1 in 23). Conclusion: Our study provides the largest database analysis of CYLD gene mutations in solid tumors and shows the distribution in numerous primary tumor sites previously unrecognized in association with CYLD. Additional studies may reveal unexpected germ-line associations and will be pursued in the future. Citation Format: Michelle Ellis, Jeff Swensen, Zoran Gatalica. Spectrum of solid malignancies associated with mutations in CYLD gene [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1722.