tbuckley/cabot-search huggingface dataset:
LETTER FROM BALTIMORE.
Authors: None E. F. C.
Journal: JAMA (1891)

(from our regular correspondent.) The Winter Course of Lectures at Johns Hopkins Hospital—Professor Welch on the Etiological Relationship of the Klebs-Lœffler Bacillus to Diphtheria —Professor Osler's Researches upon the Amœba Coli—The District Club—Miscellaneous Items. Among the special courses given this winter at the Johns Hopkins Hospital are the following: " Valvular Diseases of the Heart " and " Practical Aspects of Cerebral Localization," by Prof. Osler; " The Pathology of Bright's Disease," by Prof. Councilman; "The Historical Development of Bacteriology " and " The Development of Modern Views on Immunity," by Dr. Abbott; "Special Subjects in Bacteriology," including "The Relation of Bacteria to the Infection of Wounds," by Prof. Welch, and special subjects connected with mental disease, gynecology and surgery, by Professors Hurd, Kelly and Halstead. Contrary to the views of J. Lewis Smith, that " the Klebs-Lœffler bacillus has no more significance as a cause of diphtheria than the
Thriller
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Concerns Related to Radiation Exposure of the Female Nuclear Medicine Patient
Authors: Michael G. Stabin
Journal: Environmental Health Perspectives (1997)

The female nuclear medicine patient is of special concern in evaluating radiation dose and risk in nuclear medicine.The female's overall body size and organ sizes generally are smaller than those of her male counterpart (thus her radiation doses will be higher, given the same amounts of administered activity and similar biokinetics); female gonads are inside the body instead of outside and are near several organs often important as source organs in internal dosimetry (urinary bladder, liver, kidneys, intestines); risk of breast cancer is significantly higher among females than males; and in the case of pregnancy, exposure to radiation of the embryo/fetus and the nursing infant are of special concern in such an analysis.All these concerns are addressed in this study through a comparative study of radiation doses for males and females over a large number (-60) of nuclear medicine studies and through a study of what is known about radiation dosimetry in pregnancy and breast feeding.It was found that women's critical organ doses and effective doses (as defined by the International Commission on Radiological Protection 60 [ICRP'601) are about 25% higher than those for men across all these studies.Women's gonad doses, however, may be as much as 10 to 30 times higher than those in men, although 2to 3-fold differences are common.Many radiopharmaceuticals are administered to women of childbearing age; however, little is known about how much activity crosses the placenta and about the biokinetics in the fetus should it occur.Nonetheless, dose estimates are provided at four stages of pregnancy (early, 3-month, 6-month, and 9-month gestation) for a large number of radiopharmaceuticals, whether or not quantitative estimates of placental crossover can be made.Many radiopharmaceuticals are also excreted in breast milk of nursing mothers.Breast feeding interruption schedules are suggested through analysis of the observed kinetics of these pharmaceuticals and an assumed dose limit of 1 mSv (effective dose equivalent) to the infant.
<i>The Insanity of Over-exertion of the Brain.</i>—Being the Morrison Lectures delivered before the Royal College of Physicians of Edinburgh, session 1894. By J. Batty Tuke, M. D., F. R. C. P. E., F. R. C. S. E. With illustrations and diagrams. Oliver &amp; Boyd, Edinburgh, 1894
Journal: American Journal of Psychiatry (1895)
Erratum: Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells
Authors: Li Liu, Lihua Duan, Min Gong, Hong Dai, Quan Gong, Fang Zheng, Zheng Tan, Congyi Wang, Feili Gong, Min Fang
Journal: Cellular and Molecular Immunology (2011)
SCDT-20. NEW THERAPEUTIC APPROACH FOR BRAINSTEM GLIOMA: INTRANASAL DELIVERY OF NANOLIPOSOMAL SN-38
Authors: Xingyao He, Nundia Louis, Peng Zhang, Irina Balyasnikova, Craig Horbinski, Stewart Goldman, Rintaro Hashizume
Journal: Neuro-Oncology (2017)

± 0.01 (not significant); TKO: 0.35 ± 0.25 (p=0.0140);PKO: 0.54 ± 0.14 (p=0.0005)].Plasma concentrations in WT and TKO mice following oral administration of ispinesib were about 33% of plasma concentrations following i.p. dosing and the B:P ratios were similar.Brain concentrations are less than 5% of plasma following elacridar coadministration, and did not cause a significant increase in ispinesib brain delivery.CONCLUSIONS: Brain delivery of ispinesib is restricted by active efflux transporters (P-gp).The pharmacokinetic studies in FVB mice post intravenous administration will confirm the findings from single time point studies.
Mucormycosis
Authors: ROBERT I. LEHRER
Journal: Annals of Internal Medicine (1980)

The term mucormycosis encompasses a distinctive group of infections caused by fungi belonging to genera within the taxonomic order Mucorales, usually Rhizopus, Absidia, Mortierella, and Mucor. These fungi are widespread in nature, subsisting on decaying vegetation and diverse organic materials. Although the fungi and spores of Mucorales show minimal intrinsic pathogenicity toward normal persons, they can initiate aggressive and fulminant infections under certain clinical conditions. Ketoacidotic diabetics are predisposed to rhinocerebral mucormycosis, whereas patients with leukemia or lymphoma are susceptible to pulmonary or disseminated infections. These infections, which often result in devastating long-term sequelae for surviving patients, pose difficult diagnostic and therapeutic challenges.
Preventive approach to allergic reaction to oxaliplatin
Authors: M. Suenaga, N. Mizunuma, K. Chin, Y. Kuboki, E. Shizozaki, T. Yamaguchi, T. Muto, K. Hatake
Journal: Journal of Clinical Oncology (2007)

14569 Background: Allergic reaction to oxaliplatin is a chronic adverse event in the treatment of cancer. Patients with colorectal cancer were given FOLFOX4, using preventive approaches composed of two steps. Methods: Step I included 40 mg famotidine, 8 mg dexamethasone from the first cycle and 50 mg of diphenhydramine after cycle 4. In step II, for the patients who had a reaction but not a severe one in step I, a 20 mg dose of dexamethasone and four-hour oxaliplatin infusion were administered. Results: Forty-eight patients (15.1%) presented with allergic reaction, divided into group A receiving step I except diphenhydramine and B undergoing all of step I. Significant delay on occurrence was observed in group B. Thirty patients underwent step II. Prevention success (well-prevented) was defined as no reaction in two or more treatments. Allergic reaction appeared again in eleven patients (not well-prevented, 36.7%), but most well-prevented patients got four months longer treatment time with no reaction than not well-prevented patients. Conclusions: In our preventive approach, administration of H-1RA was effective in delaying the occurrence of allergic reaction to oxaliplatin, and increased dose of dexamethasone 20 mg and prolongation of oxaliplatin infusion from 2 to 4 hours was succeeded in continuing the FOLFOX4. No significant financial relationships to disclose.
Ancestors May Provide Clinical Answers, Say 'Darwinian' Medical Evolutionists
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A single-LTR HIV-1 vector optimized for functional genomics applications
Authors: H MA
Journal: Molecular Therapy (2004)

The development of high-throughput methods of converting simple expression cassettes into lentiviral vectors and expediting the process of retrieving vector genomes that carry candidate genes from host DNA will facilitate the use of lentiviral vectors as an efficient means of screening novel gene function. To optimize lentiviral vectors for functional genomic applications we have developed a shuttle HIV-1 vector containing a single LTR. Incorporation of a LoxP site and the SbfI restriction enzyme site into the vector LTR allowed for the rescue of integrated vector genomes into individual bacterial clones. Vector DNA isolated from bacteria was used for a second round of functional screening. Furthermore, we identified a continuous DNA sequence containing all the cis elements required for vector production. Incorporating the isolated sequence into expression cassettes resulted in the generation of HIV-1 vectors in a single cloning step, which imparts a simplified procedure for converting cDNA expression cassettes into single-LTR lentiviral vectors.
Healthspeak for all seasons
Authors: G. Dunea
Journal: JAMA (1974)

THE Comprehensive Regional Ultimate Mediplan (CRUM) is a multiagency modular system that coordinates all provider programs aimed at special consumer targets. CRUM achieves its distinctive though complementary goals through a multifaceted system of facilities linked together by a computer network. Its activities are described in its weekly newsletter, the<i>Global Planner</i>, which is written in "Healthspeak," a language that abounds in clichés specially devised to satisfy the linguistic needs of Healthplanners. CRUM programs include strong educational components—patient education, doctor education, and nurse education—with regular symposia that feature prominent out-of-town speakers, and two-day workshops with separate sessions for doctors, nurses, and technicians. High-visibility CRUM buses—painted red and with distinctive signs in large letters—will bring doctors to patients, patients to doctors, and screen for early signs of disease. Outreach facilities will be set up in a grocery, a storefront, a factory, a church, or a tent, with teams of provider paramedical healthworker
The rational clinical examination. Is this patient taking the treatment as prescribed?
Authors: B. J. Stephenson
Journal: JAMA (1993)

<h3>CLINICAL SCENARIOS</h3><h3>Case 1</h3> A 28-year-old woman presents to the emergency department in acute distress with a 3-day history of worsening asthma. Her prescribed medications include an inhaled β<sub>2</sub>-agonist and an inhaled steroid. When questioned, she breathlessly admits to "occasionally" missing her medications but indicates that this is "maybe only once or twice." <h3>Case 2</h3> A 55-year-old man with posttraumatic seizure disorder has been taking phenytoin since his injury. His seizures were initially adequately controlled but he recently has been having weekly seizures. In an office visit he resentfully denies missing any of his medication. <h3>THE IMPORTANCE OF CLINICAL EXAMINATION</h3> Physicians should measure compliance for patients prescribed a self-administered treatment because noncompliance is common and physicians can help patients to improve their compliance<sup>1,2</sup>and increase the benefit they derive from therapy. Compliance with long-term self-administered medication therapy is approximately 50% for those who remain in care.<sup>3</sup>
Woman's Hospital and Foundlings' Home.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paraneoplastic chorea: Case study with autopsy confirmation
Authors: I. W. Tremont-Lukats
Journal: Neuro-Oncology (2002)

A 67-year-old man presented with a 7-month history of insidiously progressive chorea, ataxia, and vertigo. Neurologic examination revealed deficits referable to the basal nuclei, cerebellar vermis, and vestibular nuclei. Small-cell lung cancer was diagnosed by fine-needle biopsy of a parahilar mass. After chemotherapy, the patient's chorea worsened. Anti-Hu antibodies were present in serum and cerebrospinal fluid. Microscopic examination of the brain at autopsy revealed diffuse perivascular lymphocytic infiltrates, microglial activation, and neuronophagia throughout the neuraxis, including the brainstem, cerebellum, lenticular nuclei, striatum, and cerebral cortex. Prominent loss of Purkinje cells was seen in the cerebellar vermis and hemispheres to a lesser degree. Chorea is extremely rare as a paraneoplastic manifestation of cancer. The florid presentation and the positive findings contrasted with an unremarkable MRI of the brain. This case illustrates the preeminence of symptoms and signs over negative MRI findings in paraneoplastic encephalitis.
JOSEPH HODGSON (1788-1869) PROVINCIAL SURGEON
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NECROLOGY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea Advanced Inst of Science & Tech (KAIST) JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
A Text-Book of Medical Practice for Practitioners and Students.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Twins to Study Environmental Effects
Authors: Joe C. Christian
Journal: Environmental Health Perspectives (1981)

Extrapolation from pharmacogenetic studies would indicate that there is a great deal of genetic variability in the response of humans to noxious environmental agents. Co-twins provide the most closely matched genetic controls possible and, in addition, are matched perfectly for age and often have shared very similar environments since before birth. The efficiency of co-twin control studies can be further increased by the use of sequential analysis, so that for the studies of the effects of environmental agents on human populations, twins would give answers that would require many more unrelated subjects. Use of twins in epidemiology studies is now in its infancy, but investigators should carefully consider the use of this powerful experimental tool and begin to identify twins in population surveys.
In Vitro Dissolution of Uranium Oxide by Baboon Alveolar Macrophages
Authors: Jean-Luc Poncy, Henri Metivier, Martine Dhilly, Monique Verry, Rolland Masse
Journal: Environmental Health Perspectives (1992)

In vitro cellular dissolution tests for insoluble forms of uranium oxide are technically difficult with conventional methodology using adherent alveolar macrophages. The limited number of cells per flask and the slow dissolution rate in a large volume of nutritive medium are obvious restricting factors. Macrophages in suspension cannot be substituted because they represent different and poorly reproducible functional subtypes with regard to activation and enzyme secretion. Preliminary results on the dissolution of uranium oxide using immobilized alveolar macrophages are promising because large numbers of highly functional macrophages can be cultured in a limited volume. Cells were obtained by bronchoalveolar lavages performed on baboons (Papio papio) and then immobilized after the phagocytosis of uranium octoxide (U3O8) particles in alginate beads linked with Ca2+. The dissolution rate expressed as percentage of initial uranium content in cells was 0.039 +/- 0.016%/day for particles with a count median geometric diameter of 3.84 microns(sigma g = 1.84). A 2-fold increase in the dissolution rate was observed when the same number of particles was immobilized without macrophages. These results, obtained in vitro, suggest that the U3O8 preparation investigated should be assigned to inhalation class Y as recommended by the International Commission on Radiological Protection. Future experiments are intended to clarify this preliminary work and to examine the dissolution characteristics of other particles such as uranium dioxide. It is recommended that the dissolution rate should be measured over an interval of 3 weeks, which is compatible with the survival time of immobilized cells in culture and may reveal transformation states occurring with aging of the particles.
MEDICAL ETHICS.
Authors: E. H. BOWMAN
Journal: JAMA (1884)

[Read before the Iowa and Illinois Central District Medical Association.] It is with great diffidence in myself that I presume to call the attention, and occupy any of the time of your honorable body, to the fact that, as a profession, we have a National Code of Ethics. The time was, in the not very remote ages of the past, when the profession did not have any code of morals, when every member was a law unto himself, and the majority seemed practically to adopt the Ishmaelitish tactics, involved in the patriarchal description of the progenitor of the tribe of Ishmael, viz.: “His hand is against every man,” in the practice of the medical profession. As a consequence, the sense of justice, honor, and fidelity to truth (which nowhere on earth finds more fitting and appropriate lodgment than in the bosom of our profession), was, by the eternal law of