tbuckley/cabot-search huggingface dataset:
John Warren (1753-1815), first Harvard surgeon
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
E. von Esmarch's hygienisches Taschenbuch:
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The tophus in calcium pyrophosphate deposition disease
Authors: J. C. Leisen
Journal: JAMA (1980)

A 61-year-old man had a tophus on the third finger of his right hand. There was no history of arthritis, no laboratory abnormality, and no chondrocalcinosis. Crystalline material from the tophus was identified as calcium pyrophosphate dihydrate by x-ray diffraction. (<i>JAMA</i>244:1711-1712, 1980)
Touching base
Journal: Nature Genetics (1999)

Chips go forensic"We need to see some form of identification.No, not your driver's licence, a DNA sample will do."This scenario may seem fictional, but the advent of a new coin-sized analytical DNA chip from the Nanogen corporation may change that.So far, DNA testing has been slow, requiring postage of samples for analysis (which routinely takes weeks or months, and is quite costly, averaging US $1,200 per sample).These factors have resulted in a US-wide backlog of about 600,000 samples.The new chip is intended to enable testing of DNA samples at a crime scene in only minutes, and profiles the same 13 short tandem repeats (STRs) traditionally analysed in DNA tests.Results can then be rapidly queried against the national FBI database (which went on-line last autumn) using a portable network-linked computer.Advocates of the Nanogen chip predict that it will decrease the time and cost of DNA testing significantly.Tests of the chip are scheduled to begin this month, and while police departments hope to put the technology on the street within a few years, civil libertarians fear the increased potential for abuse and discrimination that such technology might foster.According to Philip Reilly, a member of the National Commission on the Future of DNA Evidence, these fears are unfounded."It [misuse of DNA evidence] is really fantasy at this point… it would take a litany of implausible events."Reilly stresses that this is because only the 13 STR sites are used in DNA identification, which does not allow examination of other, potentially more revealing sequences that could compromise an individual's right to privacy.Reilly emphasizes that privacy must be paramount, and notes, with caution, that "no system can guarantee abuse would never happen." " "Very few scientists I know are anywhere close to loony bins.A lot more of us are like Michael Douglas-slightly evil, highly competitive.
Eosinophilic Fasciitis
Authors: Tony S. Fu
Journal: JAMA (1978)

Shulman's syndrome includes fasciitis of rapid onset, sclerodermoid skin changes, absence of Raynaud's phenomenon, absence of visceral manifestations of progressive systemic sclerosis, hypergammaglobulinemia, transient eosinophilia, and a dramatic response to systemic corticosteroid therapy. Although this syndrome may be a variant of scleroderma, its dramatic responsiveness to corticosteroid therapy is a particularly distinguishing feature. (<i>JAMA</i>240:451-453, 1978)
'Navelitis'
Authors: Charles Camisa
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Suppurative reactions to foreign bodies in body orifices are not uncommon, such as food or other objects aspirated by children or vaginal tampons inserted and forgotten. <h3>Report of a Case—</h3> We recently saw an unusual case of an obese 41-year-old man who complained of a malodorous discharge from his navel. He possessed an "inny" that he usually cleaned with a cottontipped applicator. On initial examination, a foul-smelling yellowish-green discharge was noted. The skin that could be observed at the orifice was intact and free of lesions. The navel could admit the entire length of the examiner's index finger, and no lesion was palpated by digital examination. Bacterial and fungal cultures showed no growth. An ointment containing clotrimazole, gentamicin sulfate, and triamcinolone acetonide was prescribed, which was applied with a cotton-tipped applicator. No improvement was observed after one week. The topical therapy was discontinued, and the patient was
TO LIMIT THE CASTRATION OF WOMEN.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The innocent child
Authors: H. C. Shirkey
Journal: JAMA (1966)

The innocent child, we must remember, comes to the physician usually with little choice. I shall stress the drug reactions in childhood that differ from those in adults, particularly those that are associated with growth and development. Growing children suffer drug reactions peculiar to this age group, in addition to sharing many reactions of older children and adults. Since growth and development are continuous processes, but arbitrarily divided into several periods or ages, it is obvious that many reactions may be noted in more than one period. <h3>Embryonic Period</h3> For many years we considered human pregnancy to be more secure than that of a bird. The human egg was considered to be protected even more than the avian egg; but there is little problem with a bird's egg except that the mother, and perhaps the father, stay on the nest. What they ingest makes little difference to the developing fetus.
Molecular and functional analysis of tumor-suppressor genes by transfection
Authors: R Schäfer, J Iyer, E Iten, A C Nirkko, J Balmer, R Klemenz
Journal: Environmental Health Perspectives (1991)

The transformed and tumorigenic phenotype of H-ras transfected rat FE-8 cells can be suppressed by cell fusion with normal rat embryo fibroblasts.Transfection into FE-8 cells of DNA prepared from normal human placenta followed by selective elimination of tumorigenic transfected cell clones resulted in the isolation of phenotypically normal revertants.These cells exhibited a fibroblastlike, normal morphology; were anchorage-dependent; and were unable to proliferate in medium with reduced serum concentrations.Their tumorigenicity was also reduced.The suppressed phenotype has been transferred in a second trans- fection cycle.Human repetitive DNA sequences were detected in secondary transfectant DNA.A putative human suppressor gene, designated NTS-1, has been molecularly cloned.Reintroduction of cloned NTS- 1 sequences into FE-8 cells resulted in suppression of the neoplastic phenotype in spite of a high ras expression.
OP0279 The Unfolded Protein Response Genes in Synovium and Blood Mononuclear Cells of HLA-B27 Positive Ankylosing Spondylitis Patients is not Increased Compared to Other Arthritis Patients and Healthy Controls
Authors: B. Neerinckx, S. Carter, R. Lories
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The HLA-B27 heavy chain is prone to misfolding. Misfolded proteins give rise to endoplasmic reticulum stress and activation of the Unfolded Protein Response (UPR). The UPR is strongly activated in HLA-B27 transgenic rats, an animal model for ankylosing spondylitis (AS), suggesting a role for HLA-B27 misfolding in the pathogenesis of the human disease and the UPR has been linked to IL23 production. <h3>Objectives</h3> To study endoplasmic reticulum stress and activation of the UPR <i>ex vivo</i> in the synovium and peripheral blood mononuclear cells (PBMCs) of HLA-B27 positive AS patients as compared to patients with other inflammatory joint diseases and healthy controls. <h3>Methods</h3> Synovial tissues were obtained from actively inflamed knees from patients with AS (HLA-B27 positive), other forms of spondyloarthritis (SpA) (HLA-B27 positive or negative), rheumatoid arthritis (RA) (HLA-B27 positive or negative) and other inflammatory joint diseases (‘non SpA/RA inflammatory joint disease’) (HLA-B27 positive or negative) (n=10 in each group). PBMCs were isolated from whole blood samples taken from patients with AS (HLA-B27 positive), RA (HLA-B27 negative) and healthy controls (HLA-B27 negative) (n=12 in each group). Activation of the UPR in all samples was analyzed using quantitative RT-PCR with primers for <i>DDIT3</i> (also known as <i>CHOP</i>), <i>HSPA5</i> (also known as <i>BiP</i>), <i>DNAJB9</i> and <i>XBP1s</i>. Gene expression levels were correlated to disease activity scores such as DAS28, ASDAS, BASDAI as well as to CRP levels. <h3>Results</h3> None of the UPR associated genes was specifically upregulated in either the blood cells or synovial tissue from AS patients as compared to the other groups. In the synovial samples, only <i>DDIT3</i> expression was found significantly different between healthy controls and HLA B27 negative SpA patients on the one hand and non-SpA/RA inflammatory joint disease on the other hand. There was no significant difference in expression of <i>HSPA5</i>, <i>DNAJB9</i> and <i>XBP1s</i> between the different groups. In PBMCs, expression of <i>DDIT3</i> was different between groups and levels were significantly lower in the AS group compared to the RA group and the healthy controls. There was no difference in expression of the other genes between the groups. <h3>Conclusions</h3> Our data do not provide support for a critical and unique role of the UPR in AS and other forms of SpA. The differences in expression of <i>DDIT3</i> in PBMCs with an increase in RA patient samples compared to AS patient samples suggests specific involvement of this gene in RA. <h3>Disclosure of Interest</h3> None Declared
SATIRE
Authors: William Schwartz
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Recommendations for preventing possible HTLV-III/LAV virus from tears
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
I stupidly acquired a conviction for being drunk in charge of (walking with) a moped early on in medical school, and was told at the time by (inexperienced) solicitors that it might not matter, so have tried to forget about it entirely. Applications for the F1/F2 years are due in October. What does this mean realistically for getting jobs in the next few years, and does it make me substantially less competitive from thereon?
Authors: Graeme Cunningham
Journal: BMJ (2006)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
Blue lght and jaundice.
Journal: BMJ (1970)

this point.Although a dense cellular infiltrate has consistently been observed in glomerulonephritis, particularly in active and progressive forms of the disease, little attention was paid to this observation until the resemblance to infiltrate found in allografted kidneys undergoing rejection was seen.E. Lewis, R. E. Rocklin, and J. R. David'4 have now shown that most patients with rapidly progressive glomerulonephritis have circulating lymphocytes sensitized against kidney, as well as antibody against glomerular basement membrane.The spectrum of activity and clinical course in lupus nephritis is so wide that several mechanisms, including this one, may be operating in the most severe forms.These observations of Pirofsky and Lewis and their col- leagues would suggest that cautious evaluation of A.L.G. in patients with rapidly progressive glomerulonephritis unresponsive to other forms of treatment is justified, even though present antisera and our knowledge of their action leaves much to be desired.They would also suggest that, in transplantation into patients with this form of nephritis, immunosuppression should include A.L.G. Blue Light and JaundiceLight may reduce serum bilirubin levels in neonatal jaundice,' 2 and two controlled trials3 4 have renewed interest5-8 in this effect, especially in the U.S.A. J. F. Lucey and his colleagues3 found that a "light chamber" attached to the incubator substantially reduced physiological jaundice of prematurity.F. Giunta and J. Rath4 achieved significant but less marked reduction simply by increasing the normal intensity of nursery illumination.Current knowledge on the effect of light in neonatal jaundice was summarized last year at a symposium in Chicago.8Vision, photosynthesis, and the photo-periodism of plants, which governs their season of flowering, all depend on bio-
Role of Corticosteroid Regimen On Adrenal Suppression Debated
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reproductive toxicology. Caffeine.
Authors: James Lamb, Jerry Reel, Rochelle Tyl, A Lawton
Journal: Environmental Health Perspectives (1997)

PB85101202 CH3Caffeine, a natural alkaloid drug found in tea, coffee, cocoa, and cola, and a common soft drink additive, was tested for its effects on reproduction and fertility in Swiss CD- 1 mice (Morrissey et al., Fundam Appl Toxicol 13:747-777 [1989]).Caffeine was tested simultaneously at two laboratories, each using a variation on the standard RACB study design.This study used Tasks 1, 2, and 4, while the other study in mice utilized Tasks 1, 2, and 3. Caffeine was among the very first compounds run at these labs using this protocol.Data on body weights, clinical signs, and food and water consumptions were collected during the dose-range-finding phase (Task 1), and used to set exposure concentrations for Task 2 at 0.0, 0.012, 0.025, and 0.05% in drinking water.Water was chosen to mimic the route
Prélèvement tissulaire par cholangioscopie per-orale ou cytoponction à l’aiguille fine sous échoendoscopie pour le diagnostic des sténoses biliaires
Journal: Endoscopy (2018)

La cholangiopancréatographie rétrograde endoscopique (CPRE) est un examen de choix pour la prise en charge des sténoses biliaires suspectes de malignité mais le rendement diagnostique des prélèvements reste insuffisant.
Congenital Luxation of Femur: Necropsy
Journal: BMJ (1865)

The primary, though not the only object, in the preventioni of these attacks of puerperal fever, will then be to procure a firm, complete, and persistent contraction of the uterus after the birth of the child, and thus effectually to shut off all circulation within the vessels of this organ.But it remains to be seen how far these conclu- sions accord with the results of previous observers.[ To be continued.]
Archives of Surgery, Chicago
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comminuted fracture dislocation of the proximal humerus
Authors: O. E. Aufranc
Journal: JAMA (1966)

Dr. Turner: This 53-year-old truck driver fell on an icy sidewalk, injuring his left shoulder. Despite considerable pain, marked swelling, and ecchymosis about the shoulder, the patient did not come to the hospital until 24 hours following his injury. Physical examination revealed marked ecchymosis and swelling about the left shoulder. There was no evidence of damage to the circumflex nerve. Circulation and sensation in the upper extremity were normal. X-ray films demonstrated a fracture-dislocation of the left shoulder with the shaft of the humerus displaced superiorly into the shoulder joint and the humeral head displaced anteriorly and inferiorly. There was comminution of both the greater and lesser tuberosities (Fig 1,2,3). Dr. Aufranc: This patient has sustained a very severe fracture dislocation of the shoulder with at least four separate fragments visible: the greater tuberosity, the lesser tuberosity, the dislocated humeral head, and the shaft of the humerus. This injury is