tbuckley/cabot-search huggingface dataset:
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1956)

COMMITTEE ON MATERNAL WELFAREPost-Partum HemorrhageA thirty-four-year-old gravida II, para I, died immediately post partum after an uneventful prenatal course, labor and delivery.Admitted in active labor with membranes intact, she had an intense three-hour labor, a normal infant, weighing 4.3 kg. (9 pounds, 9 ounces), being delivered half an hour after spontaneous rupture of the membranes under spinal anesthesia. A median episiotomy was performed, the baby being delivered normally as a right occiput posterior presentation. Intramuscular injection of Ergotrate was given, followed in six minutes by delivery of the intact placenta. Within half an hour, excessive flowing was . . .
Quest for Long-Term Solutions for Old Problems
Authors: William W. Kellogg
Journal: Environmental Health Perspectives (1975)

Examples of repercussions from well-intentioned controls are cited in connection with lead in gasoline, sulfur in fuel, high industrial stacks, reduction of atmospheric particulates. The importance of tradeoffs is emphasized, and the current energy crisis cited as an example. The danger of overemphasis of past errors is that the drive for control may be weakened.
BOOK REVIEWS
Authors: R. J. SCHNEIDER
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Detection and Treatment of Early Breast Cancer . Ian S. Fentiman . Philadelphia : Lippincott , 1990 , 256 pp. $69.50. ROBERT J. SCHNEIDER ROBERT J. SCHNEIDER Northern Westchester Hospital Center439 East Main St, Mount Kisco, NY 10549 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 10, 15 May 1991, Page 721, https://doi.org/10.1093/jnci/83.10.721 Published: 15 May 1991
Association of ABO Blood Group with Bleeding Severity in Patients with Bleeding of Unknown Cause
Authors: Dino Mehic, Stefanie Hofer, Christof Jungbauer, Alexandra Kaider, Helmuth Haslacher, Ernst Eigenbauer, Judit Rejtoe, Dieter Schwartz, Bernd Jilma, Cihan Ay, Ingrid Pabinger, Johanna Gebhart
Journal: Blood (2020)
MEDICAL WRITING A Short Course for Physicians
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biochemical Alterations of Lung Structure as Predictors of Chronic Lung Disease
Authors: Jerold A. Last
Journal: Environmental Health Perspectives (1983)

This presentation reports on newer animal models and techniques that we and others have developed. These models attempt to predict in a reasonable experimental time frame the occurrence of structural changes in the lungs that are the basis of various chronic diseases. Since the major chronic diseases of the lung parenchyma involving what we think of as well-understood structural changes are pulmonary fibrosis and emphysema, I will discuss in detail ways of looking at effects of air pollutants on lung collagen and lung elastin metabolism.
The Adrenogenital Syndrome
Authors: Alfred M. Bongiovanni, Allen W. Root
Journal: New England Journal of Medicine (1963)

THE adrenogenital syndrome due to congenital adrenocortical hyperplasia is a disorder of man, now properly recognized as a hereditable inborn error of metabolism. In the morphologic sense alone the involvement of the adrenal cortex and the genital changes that appear, sooner or later, in both sexes comprise the sense of the term "adrenogenital syndrome." The latter has often been interpreted generically, so that either tumor or hyperplasia of the adrenal cortex may constitute the basis of the disease. This review concerns only the form associated with adrenocortical hyperplasia and known to be related to an inherent defect of the normal . . .
Formaldehyde Poisoning
Authors: Janis Thane Eells
Journal: JAMA (1981)

THERE has been a great deal of current interest in the toxicity of formaldehyde, and most of the recent concern has centered on the release of formaldehyde into the environment from urea-formaldehyde foam used in insulation products.<sup>1</sup>However, systemic formaldehyde intoxication has not been adequately characterized, and the few reports that exist on human intoxication represent descriptive and pathologic evaluations.<sup>2,3</sup>There is little information available on the extent of formaldehyde absorption in mammals, and to our knowledge, there are no data in the literature concerning its conversion to formic acid and carbon dioxide in humans. We report a case involving the ingestion by one person of 120 mL of formaldehyde solution. Methanol, formaldehyde, and formic acid levels in the blood of the patient are reported following the ingestion of formaldehyde solution. The levels of these substances were monitored for 20 hours after admission of the patient to the hospital.
Preliminary safety and efficacy of IPI-145, a potent inhibitor of phosphoinositide-3-kinase-δ,γ, in patients with relapsed/refractory lymphoma.
Authors: Steven M. Horwitz, Ian Flinn, Manish R. Patel, Anas Younes, Francine M. Foss, Yasuhiro Oki, Jennifer Sweeney, Kerstin Allen, Joi Dunbar, Patrick Francis Kelly, Brad S. Kahl
Journal: Journal of Clinical Oncology (2013)

8518 Background: Phosphoinositide-3-kinases (PI3Ks) are pivotal in cell signaling and regulate a variety of cellular functions relevant to oncogenesis. IPI-145, a potent oral inhibitor of the PI3KEδ and PI3K-γ isoforms, is in clinical development for patients (pts) with hematologic malignancies. Early results in pts with relapsed/refractory lymphoma from an ongoing Phase 1 study are reported here. Methods: This dose-escalation study evaluates the safety, maximum tolerated dose (MTD), clinical activity, and pharmacokinetics (PK) of IPI-145. Expansion cohorts (EC) &lt; MTD are allowed. IPI-145 is given orally twice daily (BID) in 28-day cycles. Tumor response is based on standard disease-specific criteria. Results: 55 pts have been dosed with IPI-145. PK, available through 50 mg BID, are linear with complete inhibition of PI3K-δ at doses &gt; 15 mg BID and increasing suppression of PI3K-γ with increasing dose. In the 36 pts with lymphoma who received 15 mg to 75 mg BID, the median [range] number of cycles was 2.4 [0.1–10] and 67% remain on study. Treatment-related adverse events (TRAEs) occurred in 50% of pts with lymphoma. Neutropenia and increased ALT were the most common ≥ Grade 3 TRAEs (4 pts each) and were not associated with increasing dose. &gt; Grade 3 ALT elevations were more common in lymphoma pts (18%) compared to non-lymphoma pts (5%). Among evaluable pts with lymphoma (n=27), early clinical activity was observed in T-cell (n=6, 1 CR, 1 PR, 1 SD) and aggressive/indolent B-cell (n=21, 2 CR, 9 PR, 5 SD) lymphoma pts at ≤ 75 mg BID. 92% of responses were observed by 3 months. Conclusions: IPI-145 appeared well tolerated and has shown clinical activity in pts with relapsed/refractory advanced B- and T-cell lymphoma across the range of doses examined. The single agent MTD has not been determined and dose escalation continues. Updated safety and efficacy data from pts with lymphoma enrolled in dose escalation or ECs evaluating 25 mg BID and a higher dose (&lt; MTD) of IPI-145 will be presented. Clinical trial information: NCT01476657.
“Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients.” Myriam Delaunay, Jacques Cadranel, Amélie Lusque, Nicolas Meyer, Valérie Gounant, Denis Moro-Sibilot, Jean-Marie Michot, Judith Raimbourg, Nicolas Girard, Florian Guisier, David Planchard, Anne-Cécile Metivier, Pascale Tomasini, Eric Dansin, Maurice Pérol, Marion Campana, Oliver Gautschi, Martin Früh, Jean-David Fumet, Clarisse Audigier-Valette, Sébastien Couraud, Stéphane Dalle, Marie-Thérèse Leccia, …
Journal: European Respiratory Journal (2017)
NEUROPATHIC ARTHRITIS
Authors: JOHN H. DUNCAN
Journal: JAMA (1922)

For the performance of normal function, it is essential that every organ in the body not only receive an adequate supply of blood but also maintain constant communication with the central nervous system. This it does by means of afferent and efferent nerves, the former conveying information from the organ to the center and the latter carrying commands from headquarters to direct the activities of the peripheral structure. Through the afferent nerves the organism receives all impressions of the surrounding environment, and with the help of the efferent nerves suitable response is made by muscle, gland or other tissue. The simplest reflex might be conceived of as involving the sensory end-organ, its fiber and cell in the spinal ganglion with a central branch arborizing around an anterior horn cell from which arises the motor nerve conveying an efferent impulse to distant muscle. However, the vast majority of reflexes are much
PHENYLPYRUVIC OLIGOPHRENIA
Authors: PAUL W. CLOUGH
Journal: Annals of Internal Medicine (1956)

Editorial1 April 1956PHENYLPYRUVIC OLIGOPHRENIAPAUL W. CLOUGHPAUL W. CLOUGHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-4-819 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhenylpyruvic oligophrenia (phenylketonuria) is a rare malady which has aroused much interest because it offers the most clear cut example of a serious mental illness which is directly dependent upon a disturbance of metabolism. The disease was first identified by Foelling1in Norway in 1934, who observed that the urine of certain idiotic children gave an intense green color when tested with ferric chloride solution, the routine test (Gerhardt) for diacetic acid. A systematic search among hundreds of inmates of institutions for the feeble minded brought to light, in all, 10 such cases. He was able to isolate and identify...1 Foelling A: Über Ausscheidung von Phenylbrenztraubensäure in den Harn als Stoffwechselanomalie in Verbindung mit Imbezillität, Ztschr. f. physiol. Chem. 227: 169-176, 1934. CrossrefGoogle Scholar2 Penrose LS: Inheritance of phenylpyruvic amentia (phenylketonuria), Lancet 2: 192-194, 1935. CrossrefGoogle Scholar3 Jervis GA: Phenylpyruvic oligophrenia. Introductory study of fifty cases of mental deficiency associated with excretion of phenylpyruvic acid, Arch. Neurol. and Psychiat. 38: 944-963, 1937. CrossrefGoogle Scholar4 Jervis GA: Genetics of phenylpyruvic oligophrenia. A contribution to study of the influence of heredity on mental defect, J. Ment. Sc. 85: 719-762, 1939. CrossrefGoogle Scholar5 MautnerQuinn HKV: Phenylpyruvic oligophrenia, Ann. paediat. 172: 1-27, 1949. MedlineGoogle Scholar6 Cowie V: Phenylpyruvic oligophrenia, J. Ment. Dis. 97: 505-531, 1951. CrossrefMedlineGoogle Scholar7 Klein D: Über einen Fall von phenylpyruvischer Idiotie mit Zwergwuchs, Monatschr. f. Psychiat. u. Neurol. 111: 273-291, 1946. CrossrefMedlineGoogle Scholar8 Delay J: L'Oligophrénie phénylpyruvique; nouvelles observations, Bull. et mém. Soc. méd. hôp. Paris 64: 669-673, 1948. Google Scholar9 Munro TA: Phenylketonuria. Data on 47 British families, Ann. Eugen. 14: 60-88, 1947. CrossrefMedlineGoogle Scholar10 Bickel H: The influence of phenylalanine intake on the chemistry and behavior of a phenylpyruvic child, Acta paediat. 43: 64-77, 1954. CrossrefMedlineGoogle Scholar11 Woolf LL: Treatment of phenylketonuria with a diet low in phenylalanine, Brit. M. J. 1: 57-64, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistoria fenyloketonurii – pierwsze trzydzieści latSTUDIES ON PHENYLKETONURIA 1 April 1956Volume 44, Issue 4Page: 819-823KeywordsChildrenChloridesPhenylketonuriaUrine Issue Published: 1 April 1956 PDF downloadLoading ...
Long-term effect of probenecid on diuretic-induced hyperuricemia
Authors: E. D. Freis
Journal: JAMA (1966)

Because of the potentially adverse effects of chronic hyperuricemia induced by long-term treatment of hypertension with thiazide derivatives or chlorthalidone, an assessment was made of the protection afforded by the addition of probenecid. Treatment with the latter drug was maintained for a six-month period. This resulted in an average reduction in serum uric acid levels from 8.14 ± 1.27 mg/100 ml when diuretics alone were administered to 5.86 ± 1.17 mg/100 ml during the period when probenecid was added. It is concluded that probenecid affords long-term protection against hyperuricemia in nonazotemic patients with hypertension.
Irradiation Effects
Authors: G. W. Dolphin
Journal: BMJ (1969)

<h3>Background</h3> Implementation of tobacco plain packaging (PP) with larger graphic health warnings (GHWs) in Australia had positive effects on responses reflecting the specific objectives of the PP policy and on follow-up quitting-related cognitions and behaviours. The aim of this study was to examine predictive relationships between these proximal and distal outcomes. <h3>Methods</h3> A nationally representative sample of Australian adult cigarette smokers completed a baseline survey and a 1-month follow-up survey within the first year of policy implementation (n(weighted)=3125). Logistic regression analyses tested whether baseline measures of cigarette appeal, GHW effectiveness, perceived harm and concern/enjoyment predicted each of seven follow-up measures of quitting-related cognitions and behaviours, adjusting for baseline levels of the outcome and covariates. <h3>Results</h3> In multivariable models, we found consistent evidence that several baseline measures of GHW effectiveness positively and significantly predicted the likelihood that smokers at follow-up reported thinking about quitting at least daily, intending to quit, having a firm date to quit, stubbing out cigarettes prematurely, stopping oneself from smoking and having attempted to quit. Two of the quitting-related outcomes were also predicted by feeling more smoking-related concern than enjoyment. A smaller number of the appeal variables were prospectively associated with quitting-related outcomes, while believing that brands do not differ in harmfulness did not positively predict any outcomes. <h3>Conclusions</h3> These findings provide an initial insight into the pathways through which PP with larger GHWs may lead to changes in smoking behaviour. Future research should examine whether the effects are conditional on individual demographic and smoking characteristics.
Erratum: Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association
Authors: J Spelbrink, F.-Y Li, V Tiranti, K Nikali, Q.-P Yuan, M Tariq, S Wanrooij, N Garrido, G Comi, L Morandi, L Santoro, A Toscano, G.-M Fabrizi, H Somer, R Croxen, D Beeson, J Poulton, A Suomalainen, H Jacobs, M Zeviani, C Larsson
Journal: Nature Genetics (2001)
Risk Factors for Progression of Common Carotid Atherosclerosis:
Authors: Lloyd E Chambless, Aaron R Folsom, Gregory W Evans
Journal: Circulation (2001)

0005 Intima-media thickness (IMT) of the carotid arteries, as measured by B-mode ultrasound, is a marker of atherosclerosis, and as such has been shown to be positively associated with both prevalent and incident coronary heart disease (CHD) and incident stroke, and with risk factors for CHD. We examined the association of baseline risk factors or change in those risk factors with change in carotid IMT over an average nine years’ follow-up (1987-98) in the bi-ethnic population-based cohort of the Atherosclerosis Risk in Communities (ARIC) study (45-64 years old at baseline, n = 15,792). We found common carotid IMT to progress at 6 - 10 micrometers/ year, which is similar to other studies. We found, similar to other large epidemiologic studies, sizeable measurement error in IMT, which can cause large bias in estimating risk factor associations with change in IMT if adjusting for baseline IMT using standard methods. We concluded that adjustment for the potential confounding of baseline IMT, with proper correction for measurement error, generally had only a small effect on estimates of the risk factor associations. Either not adjusting for baseline IMT at all, or if doing so also correcting for measurement error by regression calibration, we found statistically significant (p &lt; 0.05) associations of IMT change with baseline diabetes, current smoking, HDL cholesterol, Lp(a), pulse pressure, white blood cell count, and fibrinogen, all in the expected direction except Lp(a). The associations were of the same order of magnitude as anticipated from our cross-sectional findings. The association with baseline triglycerides was marginally significant, while those for systolic and diastolic blood pressure, hypertension, BMI, and LDL cholesterol were not significant. We examined the associations of IMT change with change in HDL cholesterol, LDL cholesterol, triglycerides, and BMI and with onset of diabetes and hypertension, and found statistically significant associations with all but HDL cholesterol. Modifiable, established CHD risk factors are associated with the rate of change of subclinical atherosclerosis, as indexed by carotid IMT.
Johann Friedrich Horner (1831-1886) "A Form of Ptosis"
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemotherapy for liver cancer by protracted ambulatory infusion
Authors: R. D. Sullivan
Journal: JAMA (1965)

A method of treatment for cancer of the liver (primary and secondary) and the biliary tract, which consists of the protracted infusion of anticancer drugs through a plastic catheter inserted directly into the hepatic artery, was investigated. Long-term infusion was conducted for periods of weeks to months. A portable infusion apparatus was developed to permit ambulatory outpatient infusion treatment, rendering long-term infusion more practical. Eighty-one patients with neoplasms of the liver were accepted for treatment and 73 patients achieved an adequate trial of therapy. Objective response was noted in 43 patients. Survival was prolonged in patients with advanced metastatic liver cancer from primary tumors of the colorectum. Average survival was increased from the expected survival of 2.1 months to 9.4 months in this latter group. It was concluded that protracted hepatic artery infusion is of significant practical value in the management of patients with cancer of the liver.
Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice
Authors: Nobuyasu Komazawa, Morihiro Matsuda, Gen Kondoh, Wataru Mizunoya, Masanori Iwaki, Toshiyuki Takagi, Yasuyuki Sumikawa, Kazuo Inoue, Akira Suzuki, Tak Wah Mak, Toru Nakano, Tohru Fushiki, Junji Takeda, Iichiro Shimomura
Journal: Nature Medicine (2004)
Phagolysosomal pH in Alveolar Macrophages
Authors: Kristina Nyberg, Uno Johansson, Anne Johansson, Per Camner
Journal: Environmental Health Perspectives (1992)

We studied phagolysosomal pH in alveolar macrophages (AM) using fluorescein-labeled yeast (FYP) and silica particles (FSP) as probes. Fluorescence intensities from the ingested test particles were measured on populations of AM using fluorescence spectrometry and on individual phagolysosomes using fluorescence microscopy. Measurements were performed on rabbit AM, which had been incubated with FYP or FSP (in vitro procedure). We also instilled FYP or FSP via the trachea into rabbit lungs and after 1 day, 1 week, 1 month, and 3 months lavaged the lungs and measured the pH in AM (in vivo procedure). Phagolysosomal pH was independent of the number and size of the fluorescent particles. Measurements of populations of AM with fluorescence spectrometry and of individual phagolysosomes with fluorescence microscopy gave similar average pH. For the FYP, pH decreased during the first day after lavage both in the in vitro and the in vivo procedures. For the FSP, pH was unchanged during the same period. After 1 day pH was similar for both particles. Electron microscopy showed a larger number of lysosomes in contact with phagosomes and a higher percentage of vacuolated phagosomes for FYP than for FSP. In the in vivo procedure, pH was unchanged at least up to 1 month, and this pH was lower than that in the in vitro procedure. The difference was probably due to conditions at the time of phagocytosis. Particles retained in the lung parenchyma were within AM, and their location within the AM appeared unchanged from 1 week up to 3 months.