tbuckley/cabot-search huggingface dataset:
Not Slip
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ATTENDANCE AT PAST MEETINGS OF THE ASSOCIATION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemistry of Rubber Processing and Disposal
Authors: Robert L. Bebb
Journal: Environmental Health Perspectives (1976)

The major chemical changes during the processing of rubber occur with the breakdown in mastication and during vulcanization of the molded tire. There is little chemical change during the compounding, calendering, extrusion, and molding steps. Reclaiming is the process of converting scrap rubber into an unsaturated, processible product that can be vulcanized with sulfur. Pyrolysis of scrap rubber yields a complex mixture of liquids, gas, and residue in varying ratios dependent on the nature of the scrap and the conditions of pyrolysis.
An Italian Cost-Effectiveness Analysis of Paclitaxel Albumin (nab®-paclitaxel) + Gemcitabine vs Gemcibatine alone for Metastatic Pancreatic Cancer Patients: The APICE Study
Authors: C. Lazzaro, C. Barone, F. Caprioni, S. Cascinu, A. Falcone, E. Maiello, M. Milella, C. Pinto, M. Reni, G. Tortora
Journal: Annals of Oncology (2016)
Fourth Sardinian International Meeting: Models and Mechanisms in Chemical Carcinogenesis
Journal: JNCI Journal of the National Cancer Institute (1987)

Fourth Sardinian International Meeting: Models and Mechanisms in Chemical Carcinogenesis Get access JNCI: Journal of the National Cancer Institute, Volume 78, Issue 6, June 1987, Page 1254, https://doi.org/10.1093/jnci/78.6.1254-b Published: 01 June 1987
Tuberculosis
Authors: Donald S. King
Journal: New England Journal of Medicine (1950)

Para-aminosalicylic acid. It now appears that para-aminosalicylic acid (PAS) has a real place in the treatment of tuberculosis; for the first time physicians have a synthetic drug that has proved its worth in combating this disease. The original work was done in Sweden by Lehmann,70 who has given excellent reviews of the results obtained. Practically everyone agrees that it is not as effective as streptomycin. For instance, it has practically no curative effect on tuberculous meningitis. But in other conditions it is effective alone, and is especially effective if combined with streptomycin.71 It is given by mouth, usually in . . .
Correction: Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers
Journal: Cancer Research (2017)

In this article (Cancer Res 2016;76:6988–7000), which appeared in the December 1, 2016, issue of Cancer Research (1), Supplementary Table S1 included two references that were updated between the initial submission of the manuscript and the final proofing. The updates in Supplementary Table S1 are as follows:Reference 7 was changed fromtoThe authors note that the reference was updated because the QUASAR2 trial investigators had published their full results in Lancet Oncology.In addition, the following footnote was updated to a reference:The authors state that the footnote was updated to a reference because the noted meeting had taken place, and the S-TRAC trial investigators have also published their full results in the New England Journal of Medicine. The footnote was removed, and the reference was inserted into Supplementary Table S1.The new reference is as follows:The Supplementary Materials have been replaced online to reflect the changes.
Correction
Journal: BMJ (1945)

In the case of the man who was infected six months ago by the woman he proposes to marry, it is fairly obvious that he is liable to be reinfected by her unless she is treated.Certainly it would be wise to examine her, because if she infected the man, obviously she herself was infected.There is no doubt that a mild urethritis, difficult to cure and liable to relapse, has become much more common during the last three or four years than it was previously.A good deal of work has been done on it, but the cause has not yet been definitely identified and treatment is largely empirical in consequence.(See also Brit.
Preliminary Report on the Effects of Totigestational Exposure to Ethchlorvynol
Authors: Marvin A. Peters, Pearlie M. Hudson
Journal: Environmental Health Perspectives (1977)

Ethchlorvynol, a sedative-hypnotic drug used clinically since 1955, has recently been the subject of renewed interest primarily because of its chemical relationship to vinyl chloride. In our totigestational studies, sperm-positive female rats were given a daily dose of ethchlorvynol dissolved in olive oil for 21 consecutive days. The dams were allowed to deliver and their offspring were observed for alterations in development by monitoring a number of gross behavioral, histological and biochemical parameters at newborn, weanling, puberty, adult and geriatric stages. Gross development appeared normal at time of weaning: however, offspring of treated dams showed increased behavioral activity in addition to alterations in a number of clinical chemistry parameters. The dose-response seen with most of the parameters suggests that the changes are drug related. However, the clinical pathological significance has not been ascertained.
Origins and Genetic Nonvariability of the Proteins Which Diffuse from Maize Pollen
Authors: Elizabeth K. Porter
Journal: Environmental Health Perspectives (1981)

The major function of pollen is to deliver the sperm nuclei to the embryo sac. It does this by germinating and producing a pollen tube and thus provides a relatively simple developmental system for study. Mutants for many pollen functions are accessible, as it is a haploid cell. Mature pollen was fractionated into diffusible proteins, soluble proteins, and proteins insolubly associated with membrane or wall; these protein fractions have been quantified and cataloged by native and SDS polyacrylamide gel electrophoresis. Diffusible proteins are localized in the pollen grain wall whereas soluble proteins are cytoplasmic. The roles of haploid and diploid genomes in specifying these proteins is discussed. Pollen from maximally divergent maize lines was examined for quantitative and qualitative variation in the diffusible proteins. A surprising conservation was found for these proteins indicating some functional role which is, at present, unknown. Initial experiments on the incorporation of 35S-methionine into germinating pollen indicate that major representatives of the diffusible proteins are made within the pollen grain itself. They are presumably included in the pollen wall during development and diffuse out through the pore region. Studies with pollen mRNA and experiments on incorporation of 35S-methionine into developing anthers are underway and will identify the origin of these proteins. A knowledge of the basic developmental biology of maize pollen is a prerequisite to its judicious use as a monitor of environmental mutagens.
Book Review Thérapeutique Médicale. V. Peau, Syphilis et Cancer . Par Mm. M. Loeper, G. Milian, L. Bory, Cl. Simon, A. Sezary, Ch. Flandin, H. Gougerot, M. Villaret, G. Roussy, E. Schulmann, R. Proust, E. Peyre, H. Rubens-Duval, Th. Alajouanine. Masson et Cie, Éditeurs, Paris, 1932. 50 francs.
Journal: New England Journal of Medicine (1933)
Reply
Authors: W. Lloyd Clark, David S. Boyer, Jeffrey S. Heier, David M. Brown, Julia A. Haller, Robert Vitti, Husain Kazmi, Alyson J. Berliner, Kristine Erickson, Karen W. Chu, Yuhwen Soo, Yenchieh Cheng, Peter A. Campochiaro
Journal: Ophthalmology (2016)
Vertebral rim lesions in dorsolumbar spine.
Authors: R C Hilton, J Ball
Journal: Annals of the Rheumatic Diseases (1984)

Association between rheumatoid arthritis and chronic bronchial suppuration SIR, We have investigated the coexistence of rheumatoid arthritis (RA) and chronic bronchial suppuration (CBS) and concluded, in a report to be published shortly, that there is a true association between the diseases.'As part of this study we found four patients with RA who had recurrent acute respiratory tract infections associated with hypogammaglobulinaemia.Therefore we read with great interest the report of So, Peskett, and Webster2 suggesting that gold can cause immunodeficiency.Our four patients were hypogammaglobulinaemic when first investigated for their respiratory problems.All were IgM rheumatoid factor (IgMRF) negative at that time, but all had been IgMRF positive at some previous time.All had been on gold; one patient had normal immunoglobulin (Ig) levels prior to gold treatment, but baseline levels were not available in the other three.A fifth patient with IgMRF positive RA presented with acute recurrent chest infections while on gold and was found to be hypogammaglobulinaemic.Gold therapy was stopped for lack of effect and Ig levels subsequently returned to normal, but the patient developed bronchi- ectasis.The prior seropositivity of all five patients indicates that their arthritis could not itself be attributed to the hypo- gammaglobulinaemia.We suggested that: (1) gold was implicated in the genesis of the hypogammaglobulineamia, (2) this could predis- pose the patient to the development of recurrent acute chest infections, and (3) chronic bronchial suppuration might develop subsequently.The severity of chest symptoms in our study group was such that we concluded our report: 'If an inherent predisposition to infection in RA is exacerbated by disease-modifying drugs then risk factors for CBS should be identified before starting treatment with these drugs and immunoglobulins monitored regularly.A significant fall necessitates drug withdrawal.'Our own experience suggests however that such monitoring should not be confined to IgMRF negative patients.Lastly, it appears that the first case described by So et al. had 'gold lung', which is rare3 and not previously reported to be associated with hypogammaglobulinaemia.
A HINT TO THE DOUBTERS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Artificial blood.
Authors: S J Urbaniak
Journal: BMJ (1991)

taken were unjustifiable on grounds of radiological protec- tion, while some that were worth while, such as taking stable potassium iodide in the month after the accident to prevent uptake of radioiodine by the thyroid, were implemented by only about a fifth of the population.Although the IAEA project found numerous health prob- lems unrelated to Chernobyl, it found no health effects, other than psychological ones, that could be confirmed as directly attributable to radiation.This is not surprising for several reasons.The project's remit excluded those likely to have received the highest doses-namely, rescue workers, workers at the plant itself, and those who had been evacuated.Only about 1350 people currently living in the area and readily available were included in the survey.This number is big enough to identify major discrepancies between contaminated and control villages in the prevalence of common disorders or in the average value of variables such as haemoglobin concentration, but it is too small to detect a modest increase in cancers or other serious but rare disorders.Furthermore, many effects would not yet have had time to appear.Other studies of the effects of exposure to radiation have found the highest relative increase for leukaemia occurring within five years of exposure,2 but for many other cancers increases even five to 10 years after exposure are modest compared with those in later years.3Hypothyroidism may also take many years to manifest itself.Risk estimates based on the experience of other exposed populations provide a rough guide to the likely ultimate toll from Chernobyl in those continuing to live in contaminated areas.4With IAEA project estimates of dose in the 70 years after the accident and a dose rate reduction factor of 2 for cancers other than leukaemia, the estimated increase in the overall risk of fatal cancer is about 2-4% in the contaminated area, with the possibility of larger proportionate increases in
Erratum
Authors: Thomas Graham, W Brande, J Cooper, Michael Faraday, R Phillips, Robert Secretaries, Esq Warrington, G Fownies, Clinton Henry, Benjamin Swift, Green William, Esq Trousdell, Parker William, Esq Young, Ninian Christopher, Edmund English, M Der Parkes, Sinclair Patrick, John Laing, Esq Innes, Thomas Dehane, John Maitland, Brooke Townsend, D Tucker, J Dickenson, W Slegget, St Vincent, Alexander Bortlhwick, Archibald Sibbald, Horatio Handey, William Horsell, John Stocks, George Johnson, John Cuth- Bert Ithaley, John Pearson, Samuel Waudby, Theophilus Gunn, George Phillips, Arthur Newenham, Frederick Genet, John Sanders, John Henry
Journal: BMJ (1842)
Pathology
Authors: Donald E. Stanley
Journal: JAMA (1997)

Pathology version 1.1 for Windows is based on the textbook<i>Pathology</i>, by Alan Stevens and James Lowe. The textbook is suitable for students at the basic science level (first- or second-year medical students). The CD-ROM may be used with the textbook, since pagination and figure references are coordinated. The installation process is straightforward. The buttons, however, are small and therefore hard to click on. The font size is about 10 points, difficult for myopic pathologists. The credit screen includes at least 40 contributors. No help screen was available in my copy. The main screen photograph of the textbook cover features circulating red and white blood cells to give an immediate flavor for media interactivity. Four small (I mean small) buttons are present at the bottom of the screen: (1) a "flick book" introductory button allows a preview of three approximately 3-minute navigational films, including a description of use of the
Myocardial contractile reserve assessment by low dose dobutamine gated SPECT thallium-201 improves prediction of left ventricular wall motion recovery after acute myocardial infarction provided by thallium-201 uptake Marcus V. Sim�es, Osvaldo C. Almeida-Filho, Antonio O. Pintya, Nadia P. Batista, Cleide M. Antloga, Antonio Pazin-Filho, Benedito C. Maciel, Jos� A. Marin-Neto. Medical School of Ribeir�o Preto - University of S�o Paulo, Ribeir�o Preto, SP, Brazil
Journal: Journal of the American College of Cardiology (2001)
Pneumothorax during surgery
Authors: W. K. Hamilton
Journal: JAMA (1966)

A 50-year-old man had symptoms of hoarseness, sore throat, and difficult swallowing for one year. He was a heavy smoker and in recent months had noticed some shortness of breath. Roentgenograms showed mild pulmonary amphysema and subglottic tumor formation. Biopsy of the larynx established the diagnosis of epidermoid carcinoma, and laryngectomy with radical neck dissection was planned. Preoperative sedation with meperidine hydrochloride and atropine sulfate was satisfactory, and induction of anesthesia was accomplished easily with nitrous oxide, oxygen, and halothane. A moderate depth of anesthesia, as determined by clinical signs, was maintained. Respirations were assisted and compliance was satisfactory. The skin incision was designed to allow low tracheostomy. Although some bubbles had been noticed in the midline as the trachea was being dissected, things went quite smoothly until tracheostomy was performed. Shortly after an anode endotracheal tube with inflated cuff was properly placed in the distal tracheal stoma, impedance to
Gene Expression Database May Lead to More-Accurate Prognoses
Journal: Cancer Discovery (2015)

Abstract A new database that combines gene expression measurements from 166 data sets enables researchers to identify prognostic variables across 39 types of cancer. For multiple cancer types, high expression of the cell-cycle regulator FOXM1 and the presence of neutrophils in the tumor suggest a poor prognosis. The immune cell marker KLRB1 and the presence of plasma cells in tumors are strong indicators that patients are likely to survive.
Highlights
Journal: JAMA (2014)

HSCT vs Cyclophosphamide in Severe Systemic Sclerosis 2490Systemic sclerosis is an autoimmune connective tissue disease associated with vasculopathy and skin and internal organ fibrosis.In a multicenter randomized trial that involved 156 patients with early diffuse cutaneous systemic sclerosis, van Laar and colleagues found that compared with monthly intravenous pulsed cyclophosphamide, autologous hematopoietic stem cell transplant (HSCT) was associated with increased treatmentrelated mortality in the first year after treatment but higher rates of long-term event-free survival.In an Editorial, Khanna and colleagues discuss HSCT in the treatment of severe systemic sclerosis.
Abstract 14: Identification of a Major Role for Cytochrome B5 Reductase 3 in Cardiomyocyte Metabolism and Function
Authors: Adam C Straub, Nolan T Carew, Helene M Altmann, Joesph C Galley, Scott Hahn, Megan P Miller, Sruti Shiva, Dennis McNamara
Journal: Circulation Research (2017)

Cytochrome B 5 Reductase 3 (Cyb5R3) also known as methemoglobin reductase regulates redox signaling in erythrocytes and endothelial cells by maintaining heme iron in the reduced (Fe 2+ ) state. Knowing the importance of highly regulated redox signaling in other hematopoietic and somatic lineages, we conducted a pharmacological inhibition study using a CyB5R3 inhibitor in mice. Inhibition resulted in dilated cardiomyopathy (DCM) after 2 weeks. To determine the potential for human relevance, a high frequency point mutation (T117S) in African American populations was studied and served as a model to understand the impact of mutated CyB5R3 in human heart failure. We found T117S individuals associated with accelerated time to first acute cardiac events and time to death. With this evidence and the unknown function of CyB5R3 in cardiomyocytes, we created the first CyB5R3, cardiomyocyte specific inducible knockout (i-cKO) (Myh6-Cre ERT2 - flox/flox) and we observed &gt;50% lethality 15 days post-last tamoxifen injection. These mice recapitulated a DCM phenotype similar to the pharmacological study. Hemodynamic measurements showed increased left and right ventricular stroke volumes and decreased ejection fractions. Histology displayed myocardial inflammation and early stage fibrosis while electron microscopy revealed myofibril dystrophy. With these results, we hypothesized CyB5R3 i-cKO mice develop impaired metabolism and bioenergetics due to loss of CyB5R3 mediated heme reduction. I-cKO animals had smaller mitochondrial size, a 30% loss of total ATP and a rise in lactate production, indicating glycolytic shift from oxidative phosphorylation. RNAseq analysis showed decreased transcription in mitochondrial complexes I, II and IV and decreased complex IV activity. Since oxygen is the final electron acceptor for complex IV, we hypothesized the loss of CyB5R3 impaired oxygen delivery to the mitochondria. Therefore, a “psuedohypoxic state” was created, which was supported via Hypoxyprobe staining, by labeling cardiomyocytes specifically with low pO 2 . Collectively, the results provide an important breakthrough in cardiomyocyte biology by identifying Cyb5R3 as the first heme iron reductase critical for regulating cardiac metabolism.
Priorities for increasing availability of health services in rural areas
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal