tbuckley/cabot-search huggingface dataset:
Syringe Sterilizer
Authors: E. Hainsworth
Journal: BMJ (1956)

We reviewed the frequency of spontaneous remissions in spasmodic torticollis (ST). One hundred sixteen patients with idiopathic ST (72 F, 44 M) were examined. The age at onset ranged from 9 to 69 (mean, 38.1 ± 1.3). Twenty-one patients (18%) were Jewish. Eleven patients (9%) had a history of familial dystonia. Remissions longer than 1 year unrelated to treatment were observed in 14 patients (12%) (9 F, 5 M). They occurred in the first year of ST in 13 patients (93%) and in the eighth year in 1. Duration of remissions ranged from 1 to 20 years (mean, 6.5 ± 1.6). Two patients had three remissions, and another had two. The mean age at the onset of ST in patients with remission was 26.4 ± 3.3 (SEM) and ranged from 9 to 49. The age at the onset in the patients without remissions was 39.7 ± 1.4, ranging from 10 to 69 (p &lt; 0.01). In the remission group, 3 patients were Jewish (21%); in the non-remission group, 18 (18%) were Jewish. There was a familial history in 1 case with remission (7%) and in 10 cases (10%) without remission. Spontaneous remissions in the course of ST seem to be more frequent in patients with early onset, and they occur usually during the first year.
Reply
Authors: Elon H.C. van Dijk, Sascha Fauser, Myrte B. Breukink, Rocio Blanco-Garavito, Joannes M.M. Groenewoud, Jan E.E. Keunen, Petrus J.H. Peters, Greet Dijkman, Eric H. Souied, Robert E. MacLaren, Giuseppe Querques, Susan M. Downes, Carel B. Hoyng, Camiel J.F. Boon
Journal: Ophthalmology (2019)
RESEARCH IN CHEMISTRY AS RELATED TO MEDICINE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Understanding of prognosis among parents of children with cancer: Parental optimism and the role of the parent-physician interaction
Authors: J. W. Mack, E. F. Cook, J. Wolfe, H. E. Grier, P. D. Cleary, J. C. Weeks
Journal: Journal of Clinical Oncology (2006)

6033 Background: Patients often overestimate their chances of surviving cancer. Factors that contribute to accurate understanding of prognosis among parents of children with cancer are not known. Methods: We conducted a cross-sectional survey of 194 parents of children with cancer (overall response rate 70%), treated at the Dana-Farber Cancer Institute and Children’s Hospital, Boston, Mass, and the children’s physicians. Our main outcome measure was agreement between parent and physician ratings of the child’s likelihood of cure. Results: The majority of parents (61%) were more optimistic about the likelihood of their child’s cure than their child’s physician was. Most parents, however, believed that their opinions about prognosis either matched (70%) or were more pessimistic (26%) than those of their physicians. When physicians were confident in their knowledge of the child’s prognosis, parent and physician perceptions of prognosis were more likely to agree (OR 2.55, P = .004). Parents whose role in decision-making matched their ideal role were more likely to give prognostic estimates that agreed with physician perceptions of prognosis (OR 1.89, P = .019). In contrast, parent confidence in knowledge (OR .07, P &lt; .0001), coping strategies (disengagement, OR .31, P = .007; reliance on emotional support from others, OR .31, P = .029), and use of intuition to understand prognosis (OR .51, P = .012), were associated with overestimation of likelihood of cure. Conclusions: Many parents overestimate their children’s chances of being cured of cancer. Neither physician nor parent attributes alone account for this finding; rather, successful communication about prognosis requires that physicians relate to parents’ individual communication and decision-making needs. No significant financial relationships to disclose.
From the Agency for Health Care Policy and Research
Authors: J. J. Clinton
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myxedema Coma
Authors: Vincent J. Gagliardi
Journal: JAMA (1965)

Myxedema coma, first reported in 1880 but not with frequency until 1953, remains poorly understood today. Progression from hypothyroidism to myxedema and finally to coma, while generally insidious, may be hastened by complicating illness or clouded by overlying myxedema psychosis. When coma occurs it is an urgent event requiring expert handling, but established guidelines are not generally available. Physicians need a book that will interpret the scattered literature, present the basic concepts of diagnosis and management, and clarify the pathophysiology. The authors base their review on 106 previously reported cases, and supplement this with descriptions of four new patients. Problems of hypothermia, carbon dioxide narcosis, fluid and electrolyte disturbances, and cardiac arrythmias are adequately presented, and these discussions are followed by terse accounts of differential diagnosis, precipitating factors, and complications. One fourth of the text is devoted to management, with emphasis on the high mortality rate and the certain hazards
Nation's First '21st-Century' Morgue Opens With Veteran Chief Medical Examiner in Charge
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adjuvant radiotherapy for breast cancer
Authors: F. J. Ansfield
Journal: JAMA (1976)

DESPITE the diverse modifications of the classical Halsted mastectomy, which have been popularized in the past several decades, the adherents to the use of postoperative irradiation, particularly in patients found to have had cancerous axillary nodes at surgery, have remained steadfast. Of the more than 1,500 breast cancer patients with recurrent disease treated in the Oncology Clinic over the past 17 years, less than 10% of patients who had cancerous axillary nodes at mastectomy failed to receive adjuvant radiotherapy, possibly because the physicians are unaware of the results of the well-controlled study of the National Surgical Adjuvant Breast Project (NSABP),<sup>1</sup>which showed that postoperative irradiation did not increase survival in these patients. It is well recognized that while control of local chest wall disease, with its peripheral lymphatic sites, spares the patient as well as her family and physician considerable distress, radiotherapy not infrequently compounds the difficulties. With the
The Imperial Cancer Research Fund
Journal: BMJ (1904)

Physicaly defective'' IF2 657 15| pervaded by a characteristic odour.The value of a thoroughly airing of all the class rooms in the intervals is insisted upon, a[id the following observations are made.Many practical difficulties may occur to prevent such regular school perflation, but if the teachers realize its importance to their own health, to the vitality of the children, and therefore also to their mental im- pressibility, their capacities as scholars, they will endeavour to find ways of making the best of such means of ventilation as may exist.
Suppression of early atherosclerosis in LDL-receptor deficient mice by oral tolerance with $beta;2-glycoprotein I
Authors: J GEORGE
Journal: Cardiovascular Research (2004)

Background: Atherosclerosis is considered analogous to chronic inflammatory diseases. Beta2-glycoprotein I (β2GPI) is a phospholipid binding protein shown to serve as a target for prothrombotic antiphospholipid antibodies. It has recently been demonstrated to drive an immune mediated reaction and enhance murine atherosclerosis. Oral tolerance is a method in which feeding a given antigen, downregulates the respective immune responses towards it, and attenuates concomitant organ specific disorders. Herein, we tested the hypothesis, that inhibiting cellular immunity to β2GPI would result in suppression of fatty streak formation in mice. Methods and results: LDL receptor deficient mice were fed different doses of human or bovine β2GPI or BSA and than switched to an atherogenic diet. To determine the effect of feeding on lymph node proliferative indices, separate groups of mice were fed β2GPI and then immunized with the respective antigen. Feeding either human or bovine β2GPI was effective in attenuating atherosclerosis as compared to control fed animals. Oral feeding with of β2GPI inhibited lymph node cell reactivity to β2GPI in mice immunized against the human protein. Oral tolerance was also capable of reducing reactivity to oxidized LDL in mice immunized against oxLDL. IL-4 and IL-10 production was upregulated in lymph node cells of β2GPI-tolerant mice immunized against β2GPI, upon priming with the respective protein. Conclusion: Thus, oral administration of β2GPI is an effective means of suppressing atherogenesis in mice and should further be investigated.
Expert Consultants Required For Safety in Drug Evaluation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Season's Greetings
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1972)

Some Greetings of the Season are directed, some distributed, and others scattered abroad, all depending on the motives of the sender. For the occasional reader glancing at this page, the Journal's Greetings, herewith tendered, have been disseminated. But their message is also very much directed at special friends — at subscribers, authors and reviewers.These friends are indispensable. Thus, the Journal's Greetings express a heavy sense of gratitude for interest, for labor, and for advice. Yet most of these friends, the Journal's staff hopes, derive a measure of profit from their efforts: educational enrichment for readers, rewards of publication for . . .
On responsibility
Authors: C. D. Aring
Journal: JAMA (1972)

Since I was free to do as I please, I was responsible for what it was that I was pleased to do. — Carl Becker A sense of responsibility is not innate. In all human endeavor desirable characteristics do not occur in pure culture, neither do they spring up fully developed. They are under constant modification and development in the process of living. Responsibility must be learned, and, like all learning, it is likely to begin with the dawn of consciousness. Parents who are responsible with their children pass on the germ from which the trait can develop. They are supported by teachers and successively by others as the child moves into adulthood and grows in understanding. The human organism is under a constant bombardment of innuendo and direction. In a sense, developing man is offered the tools with which to model his character. It behooves all of those in
Orthopedic surgery turns attention to relatively few fractures that fail to heal over time
Authors: P. Cotton
Journal: JAMA (1990)

FEWER than 5% of bone fractures fail to heal. But, that amounts to more than 100 000 clinically symptomatic nonunions each year in the United States at a total estimated treatment cost of $2 billion. James D. Heckman, MD, bases those numbers on his definition of<i>ununited fractures</i>. He told a symposium at the American Academy of Orthopaedic Surgeons meeting in New Orleans, La, that a diagnosis should only be made 6 months after the initial injury and when no progress has been seen clinically or radiographically for at least 3 months. Heckman, professor and chair of orthopedic surgery at the University of Texas Health Science Center in San Antonio, distinguishes "delayed" unions as those that "show progress—as long as the patient is showing clinical or radiographic progress, it [the fracture] must be defined as a delayed and not a nonunion." But in some circumstances—tibial shaft fractures, for instance—they can
Prolongation of Time of "Safe" Circulation Arrest by Preliminary Hyperbaric Oxygenation and Body Cooling
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The general essentials of accredited residencies in graduate medical education
Authors: S. E. Liston
Journal: JAMA (1982)

The Resident Physicians Section (RPS) of the American Medical Association addressed many issues in 1981. However, a major portion of its efforts were focused on one issue, the first complete revision of the<i>General Essentials of Accredited Residencies in Graduate Medical Education</i>since 1955. (This is the first section of the<i>Essentials of Accredited Residencies in Graduate Medical Education</i>, which also includes the special requirements for each specialty.) This document had last been amended in 1974 and has been under revision by the new Accreditation Council for Graduate Medical Education (ACGME) for the past six years. The need for a revision of the<i>General Essentials</i>was based on two factors: (1) a new body for accreditation of residency training programs, the ACGME, had been created, and (2) the old<i>General Essentials</i>, amended several times since the mid-1950s, when they were originally initiated by the AMA Council on Medical Education, needed
Canadian J Physiolog &amp;amp; Pharm, Ottawa
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intraoesophageal variceal pressure (IOVP) and prediction of the first variceal hemorrhage in cirrhotics , R Cestari, L Carpinelli, P Ravelli, MC Vazzoler, G Missale, A Nolte, M Braga, MC Hall De Lima and R de Franchis. Cattedradi Gastroenterologia, Istituto di Medicina Interna, University of Milano, and Cattedra di Diagnostica e Chirurgia Endoscopica, University of Brescia, New Italian Endoscopic Club (NIEC), Italy
Journal: Hepatology (1993)
The variability of transfusion practice in coronary artery bypass surgery. Transfusion Medicine Academic Award Group
Authors: L. T. Goodnough
Journal: JAMA (1991)

We audited 540 patients undergoing elective first-time coronary artery bypass grafts at 18 institutions. The purposes of the study were to describe the variability in transfusions among institutions and to determine factors that may account for variability. Mean homologous red blood cell use per patient was 2.9(±0.1) U (institutional range, 0.4 to 6.3 U). One hundred seventy-seven patients (32%) received plasma (institutional range, 0% to 97%), and 119 (22%) received platelets (institutional range, 0% to 80%). After controlling for patient and surgical practice variables, transfusion practice factors still accounted for variation in red blood cell transfusions. Variation in patients receiving plasma and platelet transfusions among institutions was determined in part by prophylactic transfusions. We conclude that blood component usage for coronary artery bypass grafts differs widely among institutions. The variability in use of these components is accounted for in part by unnecessary transfusions in otherwise routine, uncomplicated coronary artery bypass graft procedures. (<i>JAMA</i>. 1991;265:86-90)
Pretreatment (pre-tx) neutrophil to lymphocyte ratio (NLR) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) treated with ketoconazole (keto): Association with outcome and predictive model.
Authors: Daniel Keizman, Maya Ish-Shalom, Natalie Maimon, Maya Gottfried, Michael Anthony Carducci, Mario A. Eisenberger, Avishay Sella
Journal: Journal of Clinical Oncology (2012)

37 Background: The CYP17 inhibitor Keto is active in mCRPC. The NLR, an index of systemic inflammation, is associated with prognosis in several types of cancer. We assessed the association between pre-tx NLR and outcome of mCRPC pts treated with keto. Methods: We performed a multicenter retrospective study of pts with mCRPC, who were treated with keto. We analyzed the pre-tx NLR and previously described factors associated with keto tx outcome as prior response to hormonal tx, pre-tx PSADT, and extent of metastatic disease (limited-axial skeleton/nodal vs extensive- appendicular skeleton/visceral). Progression free survival (PFS) was determined by the Kaplan-Meier method. Multivariate analyses using Cox regression model were performed to determine their independent effect, and to form a predictive model. A survival tree analysis was used to find the best NLR cut-off value. Results: From 1999-2011, 135 mCRPR pts were treated with keto. 67/135 (50%) had ≥ 50% PSA decline. Overall median PFS was 8 months (mos) (range 1-134 ). Excluded from the analysis were pts without available data on pre-tx NLR (n=8), and those with recent (≤1 mos) health event (surgery, n=1) or tx (steroids, n=3 or radiation, n=3) known to be associated with a change of blood counts. 120 pts were included in the analysis. 57 (48%) had an elevated pre-tx NLR &gt;3. Risk factors associated with PFS (table) were pre-tx NLR &gt;3, prior response to GnRH-a &lt;24 mos and to AA &lt;6 mos, and pre-tx PSADT &lt;3 mos. The number of risk factors was used to categorize patients into three risk groups (table): favorable (0-1 factors), intermediate (2 factors), and poor (3-4 factors). Conclusions: In mCRPC pts treated with keto, pre-tx NLR, prior response to hormonal tx, and pre-tx PSADT are associated with PFS, and may be used to categorize pts into risk groups. [Table: see text]