tbuckley/cabot-search huggingface dataset:
Abstract 19760: Longitudinal Changes in Cardiac Structure and Function After Creation of Dialysis Access in People With End Stage Kidney Disease: A 15 Year Experience
Authors: Yogesh N Reddy, Patrick G Dean, Karl A Nath, Barry L Karon, Barry A Borlaug
Journal: Circulation (2015)

Introduction: Arteriovenous fistulas(AVF) have been associated with high output heart failure but little is known about their effect on patients initiating hemodialysis. We sought to describe echocardiographic changes and identify those with incident heart failure after AVF creation. Methods: This was a retrospective analysis of all patients undergoing AVF creation over a 15 year period from 2000-2014 at the Mayo Clinic in Rochester, MN. Patients undergoing echocardiogram &lt;3 months (median 40 days) before AVF creation and &gt;6 months (median 2.5 years) following surgery were included. Patients with independent modifiers of LV structural changes (such as revascularization or myocardial infarction) were excluded by chart review. Clinical heart failure was defined by Framingham criteria. Results: From 2000-2014, 2236 patients underwent creation of AVFs and 137 patients met inclusion criteria. There was a longitudinal decrease in systolic function as evident by a drop in ejection fraction(-2%, p=0.047) with decrease in s’ tissue Doppler velocity(-0.6 cm/s, p=0.055) and increase in HR(+5 beats/min, p=0.003). There was also an increase in the prevalence of RV dilation(20 to 40%, p=0.002) and RV dysfunction(12 to 29%, p=0.002). With initiation of dialysis and decrease in weight (-7.3kg) and estimated plasma volume (-303ml) (both p&lt;0.0001), there was a decrease in LV end diastolic dimension (-2mm, p=0.006). Despite better volume control, left atrial volume index increased (+5ml/m2, p=0.004). On multivariate Cox regression, worsening RV dilation [HR 1.8 (1.06-3.09),p=0.03] was independently associated with mortality. Incident heart failure developed in 43%(28/65) with no pre-existing HF, of whom 75% had HFPEF and 25% HFrEF. The development of new systolic HF (but not HFPEF) was associated with increased age and sex adjusted mortality [HR 3.0(1.0-7.9), p=0.045]. Conclusions: AVF creation is associated with worsening biventricular function and left atrial and RV dilatation, despite reduction in LV size. These changes are coupled with high incidence of new, unexplained heart failure. Further research is needed to identify the hemodynamic mechanisms underlying heart failure development in patients with ESRD requiring dialysis access.
Table of Contents
Authors: Kira Minkis, Adam Whittington, Murad Alam, Derek Hsu, Kenneth Gordon, Jonathan Silverberg, Jon Hanifin, Charles Ellis, Ilona Frieden, Regina Fo¨lster-Holst, Linda Stein Gold, Angelo Secci, Angela Smith, Cathy Zhao, Elena Kornyeyeva, Lawrence Eichenfield, Lucinda Kohn, Yanna Kang, Richard Antaya, Nita Kohli, Susan Nedorost, Caroline Larosa, Kim Quach, Kirsten Koons, Allen Kunselman, Junjia Zhu, Diane Thiboutot, Andrea Zaenglein, Timothy Hansen, Saramarian Lucking, Jeffrey Miller, Joslyn Kirby, Marcos Gonza´lez-Lo´pez, Jose´l Herna´ndez, Marina Lacalle, Cristina Mata, Marı ´a Lo ´pez-Escobar, Raquel Lo´pez-Mejı ´as, Virginia Portilla, Patricia Fuentevilla, Alfonso Corrales, M Carmen Gonza´lez-Vela, Miguel Gonza´lez-Gay, Ricardo Blanco, Alexander Egeberg, Peter Hansen, Gunnar Gislason, Jacob Thyssen, Louise Bruun, Lotus Mallbris, Lone Skov, Jashin Wu, Athanassios Kolivras, Nathaniel Thompson, Curtis Thompson, Ketty Peris, Alessia Maiorino, Alessandro Stefani, Caterina Longo, Simonetta Piana, Giuseppe Argenziano
Journal: Journal of the American Academy of Dermatology (2016)
Is screening for early lung cancer worthwhile?
Authors: B. Merz
Journal: JAMA (1983)

Screening an at-risk population for early-stage lung cancer—a practice that has been declared ineffective by the American Cancer Society (ACS) because studies have not shown that it lowers mortality rates—nonetheless received emphatic support at the recent annual meeting of the Radiological Society of North America in Chicago. In defense of radiological screening, John R. Muhm, MD, director of diagnostic radiology at the Mayo Clinic, Rochester, Minn, cited results of the ongoing Mayo Lung Project, and Robert T. Heelan, MD, assistant attending radiologist, Memorial Sloan-Kettering Cancer Center, New York City, presented data from the National Lung Program (NLP). These programs, as well as a third conducted at Johns Hopkins University in Baltimore, are sponsored by the National Cancer Institute (NCI), Bethesda, Md. Both Muhm and Heelan emphasized that the value of radiography in detecting early-stage disease is limited to certain forms of the disease—adenocarcinoma, squamous cell carcinoma, and large-cell carcinoma—that are
Nonfatal cervical spine injuries in interscholastic football
Authors: J. P. Albright
Journal: JAMA (1976)

The incidence of nonfatal neck injuries in high school football was determined by performing preseason examinations in 104 active high school players and 75 college freshman candidates. Coaches of all 430 Iowa high schools were asked to recall the number of players experiencing significant neck pain during the season. A detailed questionnaire for each injury was also completed by a sample population of 60 coaches. The incidence of roentgenographic evidence of neck injuries was as high as 32% and was related to years of experience. Injury was most likely to occur to a linebacker or a defensive halfback when they tackled the ball carrier. In the preseason examination, half the players who volunteered a history of significant neck pain had abnormal x-ray films. (<i>JAMA</i>236:1243-1245, 1976)
MOVING PICTURE ILLUSTRATIONS IN MEDICINE
Authors: T H Weisenburg
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic gastric plication (endosleeve) improves hepatic steatosis and liver fibrosis in patients with grade 1-2 obesity, preliminary results at 6 months
Authors: Michel Ble Caso, Román Turró, Mercedes Rosinach, Javier Michelena Escudero, Roció Temiño, Alfredo Mata Bilbao, Hugo Uchima, Sonia Ruiz, Mireia Cabrera Cárdenas, Jorge Carlos Espinós
Journal: Journal of Hepatology (2020)
Radiotherapeutic management of neuroblastoma in childhood
Authors: M. Tefft
Journal: JAMA (1968)

The neuroblastoma is a malignant neoplasm of sympathetic tissue origin and can arise in any site where such tissues exist. Its metastatic spread is threefold: direct regional extension along fascial planes; lymphatic extension to regional and distant lymph node echelons; and hematogenous dissemination to bone and soft tissue. Indeed, we have frequently observed all three modes of extension in an individual patient. We have noted previously the ability of irradiation to control this disease.<sup>27</sup>However, one must be mindful of the possibility of spontaneous regression of this neoplasm without specific therapy when one evaluates any mode of therapeutic regimen.<sup>28</sup> Total surgical extirpation of the neuroblastoma is not always possible because of the tendency for early regional extension of this neoplasm. Local irradiation, therefore, plays a major role to eradicate disease. Thus, in the cases of primary involvement of the adrenal medulla, one may find localized extension to involve
Accidents and all-terrain vehicles
Authors: G. W. Trager
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I am writing in response to the article and editorial on full-text medical literature data bases in the Nov 15, 1985, issue.<sup>1</sup>There is no question that computerized data retrieval systems greatly increase the accessibility of medical data to the practitioner. However, a disturbing tendency toward fragmentation of the provision of such data may decrease the utility of electronic medical data retrieval. I am referring to the increasing number of information networks available. Not long ago, the only computerized data base available was that provided by the National Library of Medicine (MEDLARS). To my knowledge, this is still by far the most comprehensive single data base, containing nearly 4 million citations. It provides abstracts of some of the more recent articles but otherwise only gives a bibliographic citation. Other data bases have begun to include either more elaborate abstracts or full text, but from a limited
In Reply
Authors: Kenneth C. Anderson, Paul G. Richardson
Journal: Journal of Clinical Oncology (2006)

First, once a certain regimen becomes the standard of care, this implies that an alternative approach by definition is an inferior therapeutic option.We believe that the standard of care in the treatment of patients with newly diagnosed MM is to attempt attaining a remission in preparation for stem cell transplant (SCT) provided that the patient is transplant eligible.Whether the remission is achieved with singleagent D, TD, or vincristine, adriamycin, and dexamethasone is unimportant to date.There is no data to suggest that a remission achieved with TD would offer better long-term disease-free survival after SCT as opposed to D alone.It is certainly possible that this may change with long-term follow-up, but until such data is available, naming any regimen as a new standard of care seems premature.In fact, the data reported suggest that 37% of patients in the TD arm have undergone SCT, a figure comparable with patients who underwent SCT in the D arm, suggesting that single-agent D did not preclude patients from SCT.Second, one must balance therapeutic efficacy against toxicity.The data reported by Rajkumar et al 2 suggest that TD carries substantial toxicity.Peripheral neuropathy, DVT, and any grade 4 adverse event occurred at a statistically significantly higher incidence in the TD arm.These toxicities suggest that reserving the combination therapy for patients who do not respond to single-agent D is the most appropriate course of action.Since patients treated with TD are at substantial risk for DVT, it remains important to decide as to how to prevent this complication.Richardson and Anderson state in their editorial "prophylactic doses of low molecular weight heparin, full dose anticoagulation with oral warfarin, and aspirin at doses from 81 mg to 325 mg per day have all been effective." 1This statement highlights the lack of consensus among oncologists and researchers as to how to best prevent T-induced DVT.The role of different doses of aspirin in treating and/or preventing DVTs is controversial.The suggestion that either full-dose anticoagulation or simply prophylactic doses may be effective adds to the confusion among physicians and patients and begs for researchers and investigators to conduct clinical trials in this arena.It is important to understand the mechanisms of DVTs in patients who are exposed to TD and to proceed with definitive studies that would allow for better understanding of this phenomenon and how to best prevent it.A dealer's choice approach to treat DVTs in this setting is far from science and should make all of us pause before recommending this regimen to all of our MM patients.Finally, it is important to get the information and details as to the patients who were on single-agent D, but crossed over and received T when no responses were noted after four cycles.This information would allow us to understand whether the TD regimen is truly superior or that the addition of T to D would provide similar outcome if no responses are noted.
Angiologica, Basel
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Biographies of Child Development: The mental growth careers of eighty-four infants and children . A ten-year study from the clinic of child development at Yale University. Part 1 by Arnold Gesell. Part 2 by Catherine S. Amatruda, Burton M. Castner and Helen Thompson. 328 pp. New York and London: Paul B. Hoeber, Inc., 1939. $3.75.
Journal: New England Journal of Medicine (1939)
The protective efficacy of Haemophilus b polysaccharide vaccine
Authors: E. D. Shapiro
Journal: JAMA (1988)

To assess the protective efficacy of the<i>Haemophilus</i>b polysaccharide vaccine, a case-control study was conducted in Connecticut, Dallas County, and greater Pittsburgh. Seventy-six children 24 to 72 months of age who had<i>H influenzae</i>type b isolated from normally sterile sites from August 1985 through July 1987 were enrolled. For each case two controls, matched by age and place of residence, were randomly selected from the records of all live births in the area. Antecedent receipt of the<i>Haemophilus</i>b polysaccharide vaccine was ascertained from the records of all physicians and clinics at which the subjects received medical care. Overall, 12% of the cases and 39% of the controls had received the vaccine. The estimate of the protective efficacy of the vaccine was 88% overall (95% confidence interval, 74% to 96%) and 91% (95% confidence interval, 71% to 99%), 92% (95% confidence interval, 76% to 99%), and 81% (95% confidence interval, 45% to 96%) in Connecticut, Dallas County, and greater Pittsburgh, respectively. The estimates were not substantially affected by adjusting with logistic regression for differences between the cases and controls in race and the attendance of group day care. We conclude that the<i>Haemophilus</i>b polysaccharide vaccine is highly effective in these areas among children who receive the vaccine when they are 24 months of age or older. (<i>JAMA</i>1988;260:1419-1422)
A Correction
Journal: BMJ (1908)

lgal responsibility of the drunkard from the medical standpoint.12The' aimis to point out how far the alcoholic criminal is responsible, and to what extent he should be allowed the legal rights of free citizenship.The subjectmatter (to which, alas! there isno index) is treated in ten chapters, dealing respectively with crime and responsibility, general deflnition, -heredity, legal attjtude towards the drunkard, legal penalties for drunkenness, testamentary
Grundriss der inneren Medizin.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renin Suppression in Primary Aldosteronism
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From mental hospitals to jails: the pendulum swings
Authors: M. F. Goldsmith
Journal: JAMA (1983)

"Irresponsible deinstitutionalization"—release of mentally ill patients from psychiatric hospitals—is turning this country's 4,000 county and local jails into the new mental hospitals and returning care of the mentally ill to the deplorable conditions that prevailed more than 300 years ago, according to clinical psychologist Lawrence M. Cohen, MEd. Speaking at the Seventh National Conference on Medical Care and Health Services in Correctional Institutions sponsored in Chicago by the American Medical Association and American Health Care Consultants, Cohen, who is director of the Psychological Social Services Unit at Burlington County Jail, Mount Holly, NJ, said, "We are still in the Stone Age as regards treating the mentally ill in jails." Statistics show that patients dismissed from mental hospitals have begun to merge with the populations of local lockups. Writing in the 1983 edition of<i>Crime and Justice</i>, an annual review of research in the field, John Monahan, PhD, a professor of
A phase 3, open-label, randomized study of nivolumab plus ipilimumab or standard of care (SoC) vs SoC alone in patients (pts) with previously untreated unresectable or metastatic urothelial carcinoma (mUC; CheckMate 901).
Authors: Matt D. Galsky, Thomas Powles, Shengting Li, Delphine Hennicken, Guru Sonpavde
Journal: Journal of Clinical Oncology (2018)

TPS4588 Background: Cisplatin-containing regimens have been SoC for mUC for nearly 40 years, but durable responses are rare with such treatments. Furthermore, a large proportion of pts with unresectable/mUC are ineligible for cisplatin therapy. Treatment approaches conferring longer-term disease control and extending to broader mUC pt populations are urgently needed. Recently, the programmed death-1 (PD-1) inhibitor, nivolumab, induced durable responses in pts with unresectable/mUC progressing despite platinum-based chemotherapy, and nivolumab combined with ipilimumab (a CTLA-4 inhibitor) demonstrated acceptable safety and clinical activity. This phase 3 study will evaluate nivolumab + ipilimumab and nivolumab + SoC vs SoC in previously untreated pts with unresectable/mUC (NCT03036098). Methods: Key inclusion criteria: cisplatin-eligible and -ineligible pts with measurable disease, no prior systemic chemotherapy for unresectable/mUC, and evaluable tumor biopsy. Key exclusion criteria: active brain metastases, autoimmune disease, and prior treatment with drugs specifically targeting T-cell co-stimulation or checkpoint pathways. Cisplatin-eligible and -ineligible pts will be randomized 1:1 to arm A (nivolumab 1 mg/kg + ipilimumab 3 mg/kg every 3 weeks up to 4 doses, followed by nivolumab 480 mg every 4 weeks until disease progression or unacceptable toxicity) or arm B (gemcitabine-cisplatin or gemcitabine-carboplatin for up to 6 cycles). Additional cisplatin-eligible pts will be randomized to arm C (nivolumab 360 mg + gemcitabine-cisplatin every 3 weeks for up to 6 cycles, followed by nivolumab 480 mg) or arm D (gemcitabine-cisplatin for up to 6 cycles). Stratification factors: PD-1 ligand 1 status, cisplatin eligibility, and liver metastasis. Co-primary endpoints: overall and progression-free survival (OS and PFS) by blinded independent central review (BICR) in cisplatin-ineligible pts receiving nivolumab + ipilimumab vs SoC, and PFS by BICR in cisplatin-eligible pts receiving nivolumab + SoC vs SoC. Enrollment began March 2017 with a target of ~897 pts. Clinical trial information: NCT03036098.
The Caffeine Breath Test and Caffeine Urinary Metabolite Ratios in the Michigan Cohort Exposed to Polybrominated Biphenyls: A Preliminary Study
Authors: George H. Lambert, Dale A. Schoeller, Harold E. B. Humphrey, Alvin N. Kotake, Helen Lietz, Monica Campbell, Werner Kalow, Stephen P. Spielberg, Marvin Budd
Journal: Environmental Health Perspectives (1990)

A field biochemical epidemiology study was conducted using the Michigan cohort consisting of 51 rural residents exposed to polybrominated biphenyls (PBB). The study had three major objectives: a) to determine the serum half-life of the major PBB congener, hexabromobiphenyl (HBB), in the human, b) to determine if the PBB-exposed subjects had elevated cytochrome P-450I function as determined by the caffeine breath test (CBT) and the caffeine urinary metabolite ratio (CMR), and c) to determine the applicability of the CBT and CMR in field studies. PBB serum levels were detected in 36 of the 51 PBB-exposed subjects. The serum half-life of HBB was determined by comparing the current serum HBB values to the subject's previous serum values obtained 5 to 8 years earlier. The median HBB half-life was 12 years (range 4-97 years). The CBT and CMR were elevated in the subjects exposed to PBBs as compared to the values obtained from urban nonsmokers and were similar to those found in adults who smoke. A gender effect was seen in the PBB-exposed subjects, the median CBT and CMR values of the females being lower than the values of males. There was a correlation between the CBT and the HBB serum values (r2 = 0.2, p = 0.01) but not between CMR and HBB serum values. The CBT and CMR were easily conducted in the field and appear to be useful metabolic probes of cytochrome P-450I activity in human environmental toxicology.