tbuckley/cabot-search huggingface dataset:
Medicine as a force for peace. "Go, and do thou likewise"
Authors: R. B. Stark
Journal: JAMA (1966)

Does the admonition of the parable from the Gospel of Luke the great physician and its implications possess any compelling force today? Are dedication, compassion, humanitarianism too old hat or too square to be vital forces in 20th century America? Was President Johnson speaking to all of us when he said, "So very often 9-5 hours, Saturday at the country club, profit-sharing, and pension trusts all mean so much that the call (of country) is sometimes answered `No'." The answer, I feel, is found in the burgeoning body of Americans of many skills, disciplines, and professions who are volunteering to serve to help those less fortunate in areas abroad that are nonindustrialized and emerging. That our country cares enough to eschew safety for Saigon and Stanleyville, comfort for Conakry, and luxury for Laos is shown by the Peace Corps, which, in the midst of physical comfort and wealth unparalleled in
"THE MEDICAL EXAMINER SYSTEM"
Authors: Timothy Leary
Journal: JAMA (1927)

<h3>To the Editor:</h3> —May I, through you, thank Dr. Harkness for calling my attention (The Journal, October 22) to the error attributing to Edward the Confessor the statutes quoted in my paper of August 20 dealing with the medical examiner system? We are both in error, since the statutes are those of Edward IV. I can only plead guilty to a failure to refurbish my English history in preparation for my paper. The error in relation to the<i>history</i>of the coroner system is the more serious since it is my hope that within a few years the coroner will become a purely historical personage in the United States. Dr. Charles E. Norris, chief medical examiner in the city of New York, writes me that the medical examiner system obtains in New York State only in the five counties making up New York City (New York, the Bronx, Kings, Queens
Commentary
Authors: Peter D. Siersema
Journal: Endoscopy (2020)

Flexible endoscopic treatment for Zenker's diverticulum (ZD) was introduced in the mid-1990s as an alternative to the surgical technique using rigid endoscopes. It is performed by direct incision of the septum from the esophageal lumen into the diverticular space. This case illustrates the importance of incising the septum to the bottom of the diverticular space to minimize recurrences.
JAPAN
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE VARYING SUSCEPTIBILITY TO RICKETS
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tox expression on HBV-specific CD8+ T cells is linked to clinical stage of chronic HBV infection
Authors: Kathrin Heim, Bertram Bengsch, Wieland Dominik, Nina Hensel, Anna-Maria Globig, Takuya Ohtani, Marcus Buggert, E. John Wherry, Maike Hofmann, Robert Thimme
Journal: Journal of Hepatology (2020)
John Harold Talbott: Eminence in Two Careers
Authors: E.J. H.
Journal: Annals of Internal Medicine (1970)

Editorials1 January 1970John Harold Talbott: Eminence in Two CareersE.J. H., J.R. E.E.J. H.Search for more papers by this author, J.R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-1-138 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOn December 31, 1969, Dr. John Talbott ended his editorship of the Journal of the American Medical Association. In his 10 years at this post he earned the respect of the medical publishing community. Today he deserves the thanks of the medical world for his service to us all. And these are the fruits of his second career.Dr. Talbott was first eminent as an investigator in respiratory and metabolic physiology. By the age of 45 he had published 80 papers reporting clinical and investigative studies in blood chemistry, work and fatigue, high altitude effects, and gout. He had collaborated... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1970Volume 72, Issue 1Page: 138-139KeywordsBlood chemistryFatigueGoutRespiratory physiology ePublished: 1 December 2008 Issue Published: 1 January 1970 PDF downloadLoading ...
THE NEUROHYPOPHYSIS
Authors: E. M. K. GEILING
Journal: JAMA (1941)

The neurohypophysis consists of three poorly defined regions: (1) the neural lobe, (2) the infundibular stem and (3) the median eminence (or part thereof<sup>1</sup>). Because of the intimate contact of the neural and the intermediate lobe in man and most laboratory animals, these two parts of the pituitary gland are frequently classed together as the posterior lobe. However, with the clarification of the development and of the secretory capacity of the neural division of the hypophysis, it becomes expedient to abandon the use of a term based purely on gross anatomic relations. The primary structural elements of the neurohypophysis are pituicytes and unmyelinated nerve fibers. The pituicytes are derived from the ependymal cells of the neural tube and are closely related to neuroglia. They have one or more cytoplasmic processes, and frequently these end in close relation to blood vessels or connective tissue.<sup>2</sup>The nerve fibers have their
Academy of Medicine, Paris: March 7, 1843
Journal: BMJ (1843)

a memoir on the sub- ject of lithrotrity, in cases complicated witlh retention of urine, and on a newimode of extractinig the frag- ments of calculi.For this purpose the author pro- posed the3 use of an instruiment wlhich he has invented, one portion of which allows of the escape of the detritus, while througlh the other a current of water is passed into the bladder.URETHROPLASTY.
P1.04-46 PD-1 Inhibitor Plus Chemotherapy as 2nd/Subsequent Line Setting Demonstrate Superior Efficacy Over PD-1 Inhibitor Alone in Pts of Advanced NSCLC
Authors: S. Ren, Y. Liu, F. Zhou, T. Jiang, C. Su, X. Chen, C. Zhou
Journal: Journal of Thoracic Oncology (2019)
Abstract 4541: Malignant and non-malignant cells from primary tumor and lymph node metastasis ecosystems show different behavior for patient-associated protein signatures in head and neck cancer
Authors: Ariane F. Busso-Lopes, César Rivera, Barbara P. Mello, Luisa L. Villa, Wilfredo González-Arriagada, Adriana F. Paes Leme
Journal: Cancer Research (2019)

Abstract Although lymph node metastasis is the main prognostic factor in patients with head and neck squamous cell carcinoma (HNSCC), the molecular signals involved in this process are poorly characterized and no molecular markers are currently used in clinical practice. Recently, cancer is being viewed as an ecosystem, in which tumor cells cooperate with each other and host cells in their microenvironment. Herein, we mapped the proteome of primary tumor and matched lymph node ecosystems, isolating malignant and non-malignant cells, to better understand the mechanisms underlying lymph node metastasis. For that, we used formalin-fixed paraffin-embedded (FFPE) primary tumors and paired lymph nodes from 27 HNSCC patients positive (N+, n=13) and negative (N0, n=14) for lymph node metastasis using laser microdissection combined with mass spectrometry-based proteomics. An average of 2,266 ± 216 proteins was identified in primary tumor and lymph node ecosystems. A hundred and five differentially abundant proteins from malignant cells in the primary site (N+ vs N0) were mainly involved in RNA stability and metabolism, while inflammation and splicing processes, respectively, were overrepresented in N+ vs N0 non-malignant cells signatures from primary tumor (N=33) and lymph node (N=13) sites (Student's t-test; P-value≤0.05), indicating particular lymph node metastasis signatures for each cell population. Interestingly, the protein pattern of malignant cells from the primary site and matched lymph nodes showed an individual patient-specific metastasis profile through hierarchical clustering analysis; however, the profile of non-malignant cells does not represent patient-specific subpopulations and grouped according to the site of isolation (primary tumor and lymph node microenvironment). Our data reveal potential protein signatures associated with prognosis in HNSCC, as well as a non-specificity of protein patterns from host non-malignant cells that can be related with the immunosurveillance failure. Financial support: FAPESP (Process number 2015/19191-6). Note: This abstract was not presented at the meeting. Citation Format: Ariane F. Busso-Lopes, César Rivera, Barbara P. Mello, Luisa L. Villa, Wilfredo González-Arriagada, Adriana F. Paes Leme. Malignant and non-malignant cells from primary tumor and lymph node metastasis ecosystems show different behavior for patient-associated protein signatures in head and neck cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4541.
Erratum
Journal: BMJ (1898)

HEALTH OF ENGLISH TOWNS.I'M thirty-three of the lalgest English towns, including London, 6,173 births and 3,247 deaths were registered during the week ending Saturday last, June 25th.The annual rae of mortality in these towns, which had been I6.9 and 14.7 per i,oco in the two preceding weeks, rose again to I5.I last week.The rates in tlle several towns raniged from 9.6 in West Ham, 10.3 in Nolrvich, I0.9 in Croydoln, aiid II.I in Brighton, to I9.9 in Manches- ter, 20.0 in Plyllmouth. 21.4 in Sunderland, and 24,3 in Newcastle-upon- Tyne.In the thirty-two provincial towns the mean death-rate was I5.5 per ,vooo, and exceeded by i.o the rate recorded in London, wlhich was I4.5 per
Symposium on the Biologic Oxidation of Nitrogen in Organic Molecules
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Symposium on the Biologic Oxidation of Nitrogen in Organic Molecules Get access JNCI: Journal of the National Cancer Institute, Volume 58, Issue 2, February 1977, Page 467, https://doi.org/10.1093/jnci/58.2.467-c Published: 01 February 1977
THE MILWAUKEE-CHICAGO DIPLOMA MILL.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 56: Individual Susceptibility to Drug-induced QTc Prolongation Did Not Correlate With Subject-specific Induced Pluripotent Stem Cells in a Small Sample of Healthy Subjects
Authors: Ksenia Blinova, Dakshesh Patel, Jayna Stohlman, Derek Schocken, Marina Kondratovich, Lars Johannesen, Jose Vicente, David Strauss
Journal: Circulation Research (2017)

Background: Induced pluripotent stem cells (iPSCs) carry patient-specific genetic information and have the potential to become an important tool for predicting individual clinical response to therapies in an in vitro assay. Here, we investigate if subject-specific iPSC cardiomyocytes (iPSC-CMs) derived from healthy volunteers could be used to predict individual response to 2 QT-prolonging drugs which they received in a clinical trial. Methods and Results: Independent stem cell manufacturer (Stem Cell Theranostics) used commercially available Sendai virus encoding for Oct4 , Sox2 , Klf4 , and c-Myc to reprogram subject’s peripheral blood mononuclear cells (PBMCs) into iPSCs. They then applied chemically defined growth factors, and serum-free protocols to successfully differentiate iPSCs into iPSC-CMs for 17 out of 20 subjects (one batch per subject) enrolled in a randomized, double-blind, placebo-controlled, cross-over trial of dofetilide and moxifloxacin. Effects of the same 2 drugs on cellular action potential duration (APD) were recorded for 16 iPSC-CMs lines using a high-throughput optical imaging system (CellOPTIQ, Clyde Biosciences) using consistent in vitro protocols, including reproducible drug doses and exposure, cell culture and recording conditions. Both dofetilide (0.5-8 nM) and moxifloxacin (10-200 μM) induced dose-dependent prolongation of rate-corrected action potential duration (APD) in each iPSC-CM line. iPSC-CM drug responses were compared with individual clinical response represented by the slope of the linear regression fit through baseline and placebo-controlled drug-induced changes in QTc interval vs. plasma drug concentration. We found no statistical significant correlation between subject-specific iPSC-CMs drug-induced APD prolongation and individual QTc prolongation to either moxifloxacin [Spearman’s ρ = 0.191] or dofetilide [Spearman’s ρ = 0.068]. Conclusion: This study failed to find correlation between clinical and stem cell drug responses in a small sample of healthy subjects. More experiments with a larger sample size and iPSC-CMs batch-to-batch variability controls are required to further investigate the potential of patient-derived stem cells to predict individual clinical response.
Is running an analogue of anorexia nervosa? An empirical study of obligatory running and anorexia nervosa
Authors: J. A. Blumenthal
Journal: JAMA (1984)

A recent report suggested that compulsive runners share a common set of psychological traits and behavioral dispositions with patients with anorexia nervosa. In an effort to objectively assess the similarity between anorexia nervosa and obligatory running, 43 runners and 24 patients with anorexia nervosa completed the Minnesota Multiphasic Personality Inventory (MMPI). Results indicated that the obligatory runners generally scored within the normal range, while the anorectic patients did not. The anorectic patients obtained more pathological scores than the runners on eight of the ten clinical subscales of the MMPI. Fifty percent of the anorectic patients obtained elevations on three or more of the MMPI subscales, while no runners obtained more than two scale elevations. Depression (scale 2) and psychopathy (scale 4) were particularly prevalent in the anorectic group. We conclude that obligatory runners do not suffer from the same degree of psychopathology as do patients with anorexia nervosa. (<i>JAMA</i>1984;252:520-523)
Will mountains trekkers have heart attacks?
Authors: D. Rennie
Journal: JAMA (1989)

A consequence of the fitness boom has been that it is now commonplace for symptomless people to go to their physicians to be checked out before they take up jogging, racquetball, or aerobic dancing. What most people are concerned about is the presence of coronary arterial disease and the possibility that the exercise will cause sudden death or myocardial infarction. The public, persuaded that such checkups are as crudely mechanistic as those for automobiles, is happy to pay physicians to carry them out, although there is little evidence that such routine checks effectively reduce morbidity or mortality from subsequent exercise. Increasing affluence and a greater interest in the outdoors have caused ever larger numbers of people to go to the mountains to exercise—either to climb, walk (trek), or ski cross-country. (Downhill skiing, where the work is done by the lift, is not an impressive aerobic challenge.) Many of these people
Limited list
Authors: A. Bamji
Journal: BMJ (1985)

Discovery of biomarkers has been steadily increasing over the past decade. While a plethora of biomarkers have been reported in the biomedical literature, few have been sufficiently validated for broader clinical applications. One particular challenge that may have hindered the adoption of biomarkers into practice is the lack of reproducible biomarker cutpoints. In this article, we attempt to identify some common statistical issues related to biomarker cutpoint identification and provide guidance on proper evaluation, interpretation, and validation of such cutpoints. First, we illustrate how discretization of a continuous biomarker using sample percentiles results in significant information loss and should be avoided. Second, we review the popular ‘minimal p-value approach’ for cutpoint identification and show that this method results in highly unstable p-values and unduly increases the chance of significant findings when the biomarker is not associated with outcome. Third, we critically review a common analysis strategy by which the selected biomarker cutpoint is used to categorize patients into different risk categories and the difference in survival curves among these risk groups in the same dataset is claimed as the evidence supporting the biomarker’s prognostic strength. We show that this method yields exaggerated p-value and overestimates the prognostic impact of the biomarker. We illustrate that the degree of the optimistic bias increases with the number of variables being considered in a risk model. Finally, we discuss methods to appropriately ascertain additional prognostic contribution of the new biomarker where standard prognostic factors already exist. Throughout the article, we use real examples in oncology to highlight relevant methodological issues and when appropriate, use simulations to illustrate more abstract statistical concepts.
Donovan Ward, MD, Is AMA President
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Zinsser Microbiology
Authors: W. G. Brandstadt
Journal: JAMA (1960)

Originally published in 1910 by Hiss and Zinsser, this textbook has undergone many revisions and changes of title, the last in 1957. The present authors state in their preface that in the last 10 years most departments of bacteriology have expanded to include mycology and parasitology. The text has, therefore, been renamed<i>Microbiology</i>. In this edition, the chapter on general morphology and reproduction of bacteria has been rewritten. Other additions include a discussion of Asian influenza and the hemadsorption viruses. The public health aspect of each subject has been emphasized. New illustrations, some of them in color, have been provided. The various sections deal with the general biology of bacteria and general methods of bacteriology, physiology of micro-organisms, ecology, immunology, pathogenic bacteria, spirochetes, the pleuropneumonia group of organisms, rickettsiae, viruses, mycology, parasitology, and technical methods. There is an appendix on the antigenic structure of salmonellae. At the end of each