tbuckley/cabot-search huggingface dataset:
Abstract 756: Whole exome sequencing identifies frequent mutations of PTPRB and KDR in secondary angiosarcoma
Authors: Tenzin Gayden, Brendan C. Dickson, Hamid Nikbakht, Pierre-Olivier Fiset, Nicolas De Jay, Javad Nadaf, David L. Burk, Albert Berghuis, Rebecca Gladdy, Jay Wunder, Robert Turcotte, Jacek Majewski, Nada Jabado
Journal: Cancer Research (2019)

Abstract Angiosarcoma is an uncommon malignant vascular tumor that can occur anywhere on the body, with a predilection for the skin or soft tissues of the scalp and face. By whole exome sequencing, we identified recurrent somatic mutations in PTPRB, which encodes an endothelial-specific phosphatase that negatively regulates angiogenesis, in three secondary angiosarcoma tumors (3/10). In addition, four tumors harbored missense variants in the KDR gene, including three germline substitutions. Neither the PTPRB nor the KDR alterations were found in the 5 primary tumors studied. Copy number analysis derived from the exome and methylation data revealed frequent MYC amplification in the majority of secondary angiosarcoma tumors (9/10). Altogether, our data provide a comprehensive overview of genetic and epigenetic landscapes of angiosarcoma, and demonstrate that aberrant angiogenesis associated with PTPRB and KDR mutations may contribute to the pathogenesis of angiosarcoma. Citation Format: Tenzin Gayden, Brendan C. Dickson, Hamid Nikbakht, Pierre-Olivier Fiset, Nicolas De Jay, Javad Nadaf, David L. Burk, Albert Berghuis, Rebecca Gladdy, Jay Wunder, Robert Turcotte, Jacek Majewski, Nada Jabado. Whole exome sequencing identifies frequent mutations of PTPRB and KDR in secondary angiosarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 756.
“The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.” Louise Fleming, Clare Murray, Aruna T. Bansal, Simone Hashimoto, Hans Bisgaard, Andrew Bush, Urs Frey, Gunilla Hedlin, Florian Singer, Wim M. van Aalderen, Nadja H. Vissing, Zaraquiza Zolkipli, Anna Selby, Stephen Fowler, Dominick Shaw, Kian Fan Chung, Ana R. Sousa, Scott Wagers, Julie Corfield, Ioannis Pandis, Anthony Rowe, Elena Formaggio, Peter J. Sterk and Graham Roberts on behalf of …
Authors: Louise Fleming, Clare Murray, Aruna Bansal, Simone Hashimoto, Hans Bisgaard, Andrew Bush, Urs Frey, Gunilla Hedlin, Florian Singer, Wim Van Aalderen, Nadja Vissing, Zaraquiza Zolkipli, Anna Selby, Stephen Fowler, Dominick Shaw, Fan Chung, Ana Sousa, Scott Wagers, Julie Corfield, Ioannis Pandis, Anthony Rowe
Journal: European Respiratory Journal (2017)
The natural history of prenatally diagnosed cerebral ventriculomegaly
Authors: A. Drugan
Journal: JAMA (1989)

Intrauterine treatment of fetal cerebral ventriculomegaly has been largely abandoned, as the results have been disappointing compared with those of standard neonatal treatment. However, we suggest that the natural history of ventriculomegaly diagnosed in utero has not been studied adequately and that fetal surgery may have a role in selected patients. We have analyzed the outcome in 43 cases of fetal ventriculomegaly followed up without active treatment in utero. Our data suggest that the prognosis is poor for fetuses with ventriculomegaly and coexistent malformations, good for those with isolated, nonprogressive ventriculomegaly, and variable for those with progressive, isolated ventriculomegaly. (<i>JAMA</i>. 1989;261:1785-1788)
Error in Conflict of Interest Disclosures
Journal: JAMA Surgery (2019)

In the article titled "Association of Attending Surgeon With Variation in the Receipt of Genetic Testing After Diagnosis of Breast Cancer," 1 the wording regarding guidelines referred to in the Discussion has been revised for accuracy.The guidelines referred to had not been published at the time of the study, 1 so the sentence, "Guidelines published after this study was conducted recommend pretest genetic counseling and acknowledge that the complexities in interpretation of modern panel testing require that providers (eg, laboratories, oncology physicians, and counselors) with particular expertise in cancer risk assessment be involved in their ordering and interpretation," was added for clarification.The article was corrected online.
Intra-articular Hyaluronic Acid for Treatment of Osteoarthritis of the Knee
Authors: Roland Moskowitz, Roy Altman
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Matrix metalloproteinase-2 levels and features of atherosclerotic plaque vulnerability. An intracoronary ultrasound study Manolis Vavouranakis, Kostadinos Toutouzas, Christodoulos Stefanadis, Costadina Aggeli, Christina Chrysochou, Dimitris Markou, Emanouil Economou, Sofia Vaina, Pavlos Toutouzas. Cardiology Department, Hippokration Hospital Of Athens, Athens, Greece
Journal: Journal of the American College of Cardiology (2001)
Acute toxicity and early quality of life after dose intensified salvage radiotherapy for biochemically recurrent prostate cancer after prostatectomy: First results of the randomized trial SAKK 09/10.
Authors: Pirus Ghadjar, Tobias Hoelscher, Philipp Gut, Matthias Guckenberger, Guido Hildebrandt, Arndt-Christian Mueller, Ludwig Plasswilm, Alexandros Papachristofilou, Stefanie Hayoz, Marcin Sumila, Helmut Kranzbuehler, Yousef Najafi, Piet Ost, Ngwa C Azinwi, Daniel Rudolf Zwahlen, Christiane Reuter, Stephan Bodis, Peter Wust, Juerg Bernhard, Daniel M. Aebersold
Journal: Journal of Clinical Oncology (2015)

5038 Background: Patients (pts) with biochemical recurrence after radical prostatectomy may benefit from dose intensified salvage radiotherapy (RT) of the prostate bed. We performed a randomized phase III trial assessing dose intensification. In this first report we report acute toxicity and early quality of life (QoL). Methods: Pts with biochemical recurrence but without evidence of macroscopic disease were enrolled in this randomized phase III trial. Pts were randomly assigned to either 64 Gy (32 daily fractions) or 70 Gy (35 daily fractions). Three-dimensional conformal RT (3D-CRT) or intensity-modulated RT (IMRT, or equivalent rotational techniques) were accepted techniques. The primary endpoint was freedom from biochemical recurrence. Secondary endpoints included acute toxicity according to the CTCAE v4.0 and QoL using the EORTC QLQ-C30 and PR25. Results: We enrolled 350 pts between 02/2011 and 04/2014. Three pts withdrew consent and three were not eligible, resulting in 344 pts in the safety population. Thirty (8.7%) and two (0.6%) pts had grade 2 and 3 genitourinary (GU) baseline symptoms. Acute grade 2 and 3 GU toxicity was observed in 22 (13.0%) and 1 (0.6%) with 64 Gy and 29 (16.6%) and 3 (1.7%) with 70 Gy, being not significantly different (p = 0.2). Baseline grade 2 gastrointestinal (GI) toxicity was observed in 1 (0.6%) patient. No baseline grade 3 GI toxicity was observed. Acute grade 2 and 3 GI toxicity was observed in 27 (16.0%) and 1 (0.6%) with 64 Gy and 27 (15.4%) and 4 (2.3%) with 70 Gy, again not significantly different (p = 0.8). Changes in QoL were marginal. However, pts receiving 70 Gy reported a more pronounced and clinically relevant worsening in urinary symptoms (mean difference between arms 3.6, p = 0.02). There was no significant difference between 3D-CRT and IMRT/rotational techniques. Conclusions: Dose-intensified salvage RT was associated with a low rate of grade 2 and 3 GU and GI toxicities. The impact of dose intensified salvage RT on QoL was marginal, with the exception of a worsening in urinary symptoms after 70 Gy. Clinical trial information: NCT01272050.
Cystadenoma of the Pancreas: Its Arteriographic Diagnosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk of Serious Infections and Malignancies With Anti-TNF Antibody Therapy in Rheumatoid Arthritis
Authors: David Hochman, Bruce Wolff
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACUTE INFECTION OF THE THYROID GLAND
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electron Spin Resonance (ESR) Study of Cigarette Smoke by Use of Spin Trapping Techniques
Authors: William A. Pryor, Ken-ichi Terauchi, William H. Davis
Journal: Environmental Health Perspectives (1976)

The technique of spin trapping has been applied to the gas phase of cigarette smoke to identify and quantify the radicals present. It was found that radicals could be trapped only if the smoke was filtered. Three spin traps were used: N-tert-butyl-alpha-phenyl nitrone (PBN). 5,5-dimethyl-delta1-pyrroline-1-oxide (DMPO) and alpha-[3,5-di-tert-butyl-4-hydroxyphenyl)-N-tert-butyl nitrone (OHPBN). From the electron spin resonance (ESR) splitting constants of the radicals produced by the reaction of smoke radicals with the spin traps and also from the effec of varying the path length between the cigarette and the spin trap solution, it is concluded that three types of signals are observed. Type I signals indicate the presence of oxygenated radicals which appear to be a mixture of alkoxy radicals (RO) and aroyloxy (ArCO2-) radicals. Our data do not allow conclusions about the nature of the R or Ar groups in these two oxy radicals; however, considerations based on lifetimes suggest that the R group probably is tertiary. Type II and III signals are not typical spectra of spin adducts. Instead, we believe they result from reaction of smoke (and probably radicals in smoke) with the PBN spin trap and indicate that smoke has the ability to effect one-electron oxidations. Only type I signals are observed with DMPO and OHPBN. A quantitative study shows that 4 x 10(14) spins/puff are present in the smoke, in contrast with the result of a recent study which used a very different method for determining the radical content of smoke. A discussion of the nature of the radicals in smoke and some tentative conclusions are presented.
Index Editorial Board
Authors: Donald Leung, Colo Deputy, Harold Nelson, Stanley Szefler, Colo Associate, Andrea Apter, Bruce Philadelphia, Baltimore Bochner, Robert Bush, Fred Finkelman, William Shearer, David Peden, Scott Sicherer, New York, Donata Vercelli, Ariz Guest, Burton Zweiman, Marc Rothenberg
Journal: Journal of Allergy and Clinical Immunology (2005)
Pulmonary Toxicology of Silica, Coal and Asbestos
Authors: A. G. Heppleston
Journal: Environmental Health Perspectives (1984)

Mineral particles are customarily inhaled as mixtures, though one component may predominate and determine the response. Although the lesions often possess a characteristic structure, according to the main type of particle deposited, morphology affords little indication of pathogenesis. Being a major element in the evolution of dust lesions, macrophage behavior has been examined extensively in vitro after treatment with mineral particles, attention being directed to membrane and biochemical changes; however, no clear lead to the origin of the lesions has emerged. Pulmonary fibrosis, as one of the ultimate consequences of dust accumulation, required a direct in vitro approach in which the products of the macrophage-particle interaction were utilized to provoke collagen formation by fibroblasts in a two-phase system. By this means, silica and asbestos stimulated connective tissue formation and application of the technique to coal dusts appears promising. Coal workers may develop a peculiar type of emphysema in relation to lesions whose fibrous content is comparatively small. Type II alveolar epithelium is also stimulated by inhaled particles and lipid accumulation follows. Alveolar lipidosis interferes with the fibrotic response by preventing contact between macrophage and particles. This phenomenon may account in part for anomalies, apparent in coal workers, between epidemiological findings and dust composition. Carcinogenesis is a well-recognized feature of asbestos exposure, but, as with fibrosis, risk prediction on the basis of in vitro tests of cytotoxicity is premature and may not be valid.
Resources Irreplaceable and Pollution
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug Tests in Pregnant Women: Abuse of Substance or of Test?-Reply
Authors: Sidney H. Schnoll
Journal: JAMA (1989)

<h3>In Reply. —</h3> Ms Moss raises many issues about the drug testing of pregnant women. Critical components of any testing policy include the following: (1) the purpose of testing, (2) the context of testing, (3) who is to be tested, (4) whether testing is voluntary or involuntary, (5) the specificity and sensitivity of the assay employed, (6) the confidentiality of the results, and (7) the therapeutic and/or punitive measures that occur as an outcome of the procedure. As indicated in our article, we favor the functional testing of job performance in the workplace rather than random urine testing. When an individual is found to be impaired, then we propose that the cause of this impairment should be determined, followed by appropriate therapy. Urine testing alone does not determine impairment or the presence of addiction. To label a person an addict and recommend treatment on the basis of a single test
CUTANEOUS DETERGENTS
Authors: C. GUY LANE
Journal: JAMA (1942)

<h3>I. INTRODUCTION</h3> The use of some cleansing agent with water is necessary to maintain satisfactory skin hygiene. While a survey of the literature reveals some articles on skin cleansing, especially with regard to soap, little has been done to determine the most satisfactory method of cleansing the skin or to learn what effect cleansing processes have on the skin itself. An attempt to cite all available references would lead to useless duplication. Wherever possible, papers are cited in this presentation which include complete bibliographies and which have been published in readily available American or English periodicals. A symposium<sup>1</sup>on the subject of cleansing the normal and abnormal skin was held in 1934 in Germany, but in general even the dermatologic textbooks devote an insignificant amount of space to the subject. Physicians in general give the matter little thought. One is apt to assume that a patient keeps up satisfactory
Acute Osteomyelitis
Authors: Raymond G. Tronzo
Journal: JAMA (1962)

<h3>To the Editor:—</h3> The article titled "Current Status of Therapy in Acute Osteomyelitis" by Koenig and Rogers (<i>JAMA</i><b>180</b>:1115-1118 [June 30] 1962) deserves comment. They state: "Recently, the incidence of diagnosable osteomyelitis has declined sharply, morbidity has been markedly diminished..." This statement does<i>not</i>reflect published reports and a growing concern among those who must treat this disease. Winters and Cahen<sup>1</sup>opened their article with: "Acute hematogenous osteomyelitis is a common and at times a tragic disease. During the years 1956, 1957, and 1958, the incidence of this disease has greatly increased (chart 1)." A similar trend was found at the Philadelphia General Hospital and reported.<sup>2</sup> Drs. Koenig and Rogers state further that "... the recent development of potent antibacterial drugs has had a profound impact on treatment, and the role which surgical therapy plays is now a subject of vigorous argument." They use the article by Winters
Immunohistochemical Detection of the Epstein-Barr Virus–Encoded Latent Membrane Protein 2A in Hodgkin's Disease and Infectious Mononucleosis
Authors: G. Niedobitek, E. Kremmer, H. Herbst, L. Whitehead, C.W. Dawson, E. Niedobitek, C. von Ostau, N. Rooney, F.A. Grässer, L.S. Young
Journal: Blood (1997)
Patient-Centered Medicine
Authors: Carlos A. Reyes-Ortiz
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Patient-centered medicine is an ideal. However, there is not evolution toward this goal in several critical areas of medical practice.<sup>1</sup>Studies show that physicians communicate inadequately with both elderly and seriously ill patients. Brennan et al<sup>2</sup>reported that hospitalized elderly patients had the higher risk for negligence-related adverse events. The SUPPORT project<sup>3</sup>showed that physicians often failed to communicate with seriously ill hospitalized patients. In addition, physicians failed to incorporate patients' perspectives, and high technology was a risk to patients' quality of life. To improve the patient-physician relationship, we must change the physician. One strategy is teaching countertransference to reduce the potential harmful effect and enhance the positive effect of the physician on the patient. Physicians often have not wanted to treat elderly patients, have ignored normal aging, and have failed to recognize their own aging process.<sup>4</sup>Learning about normal aging and being
Foreword
Authors: J. L. Burton
Journal: British Journal of Dermatology (1985)

Journal Article Foreword Get access J. L. Burton J. L. Burton Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Page 1, https://doi.org/10.1111/j.1365-2133.1985.tb12956.x Published: 01 July 1985