tbuckley/cabot-search huggingface dataset:
A Model for the Formation of Airborne Particulate Matter Based on the Gas-Phase Adsorption on Amorphous Carbon Blacks
Authors: Terence H. Risby, Shelley S. Sehnert
Journal: Environmental Health Perspectives (1988)

This paper reports the physicochemical properties that describe the adsorption of a series of solutes onto the surfaces of amorphous carbon blacks. Adsorption was studied at concentrations that correspond to low surface coverages and in the presence of volatile solvent diluents. The adsorbates and adsorbents were selected for their relevance as models for environmental agent-particle complexes originating from incomplete combustion. The data clearly show that the major factors that determine the strength of adsorption are the surface properties of the adsorbent and the intermolecular forces between the surface and the adsorbing molecule. The heat of adsorption data have been used to predict the lifetime of the absorbate-adsorbent complexes.
IARC Fellowships for Research Training in Cancer, 1986–87
Journal: JNCI Journal of the National Cancer Institute (1985)

IARC Fellowships for Research Training in Cancer, 1986–87 Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 3, September 1985, Page 593, https://doi.org/10.1093/jnci/75.3.593-c Published: 01 September 1985
Treatment of coccidioidomycosis with miconazole
Authors: P. D. Hoeprich
Journal: JAMA (1980)

Miconazole was injected intravenously in six patients with coccidioidomycosis. Two patients received 101 and 185 g, respectively, without clinical response and with persistence of positive cultures for<i>Coccidioides immitis</i>. In one patient, symptoms were suppressed when amphotericin B was given with miconazole, but new lesions developed with miconazole alone (total dose, 963 g). Three patients received smaller doses: 30.6 g before death from an unrelated complication; 17 and 22.3 g before development of severe allergic reactions. Because of the high rate of initial failures and relapses, miconazole is not recommended as primary therapy for coccidioidomycosis. (<i>JAMA</i>243:1923-1926, 1980)
Good Food and Bad Stomachs: 500 Delicious and Nutritional Recipes for Sufferers from Ulcers and Other Digestive Disturbances
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decongestant-induced blepharospasm and orofacial dystonia
Authors: J. M. Powers
Journal: JAMA (1982)

DECONGESTANTS are ubiquitous drugs, frequently obtained without a prescription and often used habitually. Dystonic reactions may rarely result from long-term use of decongestants. Self-medication may go unrecognized, obscuring the diagnosis. A 34-year-old man had blepharospasm and orofacial dystonia. Habitual use of a decongestant spray was eventually acknowledged, and the dyskinesia decreased substantially when use was discontinued. Persons with blepharospasm or orofacial dystonia should be questioned specifically about use of decongestants. <h3>Report of a Case</h3> A 34-year-old man complained of eye irritation and spasms of eye closure of three months' duration, which he attributed to new soft contact lenses. Ocular irritation, tearing, photophobia, and blepharospasm gradually increased in severity until he was unable to read or work. Discontinuation of use of the contact lenses and therapy with a variety of topical medications did not alter the symptoms. Spasms were increased by bright light, reading, and stress. They persisted throughout the day,
MYOCARDITIS IN PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS
Authors: Syed Mahmood, Michael G. Fradley, Justine V. Cohen, Anju Nohria, Kerry L. Reynolds, Lucie M. Heinzerling, Ryan J. Sullivan, Rongras Damrongwatanasuk, Carol Chen, Dipti Gupta, Michael C. Kirchberger, Javid Moslehi, Sachin Shah, Sarju Ganatra, Paaladinesh Thavendiranathan, Donald P. Lawrence, John D. Groarke, Tomas G. Neilan
Journal: Journal of the American College of Cardiology (2018)
Magnetic resonance imaging of the head and neck region. Present status and future potential. Council on Scientific Affairs. Report of the Panel on Magnetic Resonance Imaging
Journal: JAMA (1988)

Magnetic resonance imaging (MRI) has many bona fide applications in the head and neck region. The major strengths of its current conventional use include excellent soft-tissue contrast, multiplanar capabilities, noninvasiveness, and lack of ionizing radiation. Newer advances, including gradient-echo techniques, three-dimensional fourier transformation, paramagnetic contrast, and more efficient receiver coils, will improve images and expand indications for MRI. The technology, however, remains relatively expensive, and the additional information compared with that of other techniques might not always justify the difference in cost. Moreover, MRI's insensitivity to calcifications, lack of depiction of fine bone detail, and, in some areas, degradation caused by motion and other artifacts make computed tomography and other noninvasive studies more appropriate as a primary imaging tool in many circumstances. Continued careful clinical research should clarify the relative role of MRI and other imaging tools during the next several years.
Screening for Chlamydia trachomatis: A Case for Empirical Treatment
Authors: Christopher E. Spitters
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The article by Dr Shafer and colleagues<sup>1</sup>regarding urine-based screening strategies to detect<i>Chlamydia trachomatis</i>infection among sexually active asymptomatic young men provided valuable information. As part of a Chlamydia Prevention Initiative in San Diego County, California, we advocate that sexually active asymptomatic adolescent males be screened during routine preventive health care visits, such as during sports physicals. We recommend first-void urine leukocyte esterase (LE) testing because it can be done in the physician's office at negligible cost (approximately 30 cents). For adolescents with a positive LE, especially those engaging in high-risk sexual behavior, we recommend strong consideration of empirical treatment, and for others, further evaluation and confirmatory testing. Confirmatory testing may not be available in certain settings, mainly because of cost concerns, and even when it can be done, some adolescents may not return to obtain results or treatment. Therefore, there is a need for a
"Rhinovirus induces MUC5AC in a human infection model and in vitro via NF- B and EGFR pathways." C.A. Hewson, J.J. Haas, N.W. Bartlett, S.D. Message, V. Laza-Stanca, T. Kebadze, G. Caramori, J. Zhu, M.R. Edbrooke, L.A. Stanciu, O.M. Kon, A. Papi, P.K. Jeffery, M.R. Edwards and S.L. Johnston. Eur Respir J 2010; 36: 1425-1435.
Journal: European Respiratory Journal (2012)
Religious Coping and Life-Prolonging Care
Authors: Hanneke W. M. van Laarhoven
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
840. Markedly Enhanced Cytolysis by E1B-19kD-Deleted Oncolytic Adenovirus in Combination with Cisplatin
Authors: A-Rum Yoon, Young-Sook Lee, Ji-Young Yoo, Hoguen Kim, Jinsun Kim, Joong Bae Ahn, Joo-Hang Kim, Chae-Ok Yun
Journal: Molecular Therapy (2006)

Oncolytic adenoviruses are currently being developed as novel antitumor therapeutics. To enhance their therapeutic potential, adeonoviruses are being administered in combination with standard chemotherapy. Adenoviral vectors used in these clinical trials, however, can be destructive as they encode intact E1B 19-kDa protein, which can block the apoptotic pathway induced by a variety of chemotherapeutic agents. Previously, we have shown that oncolytic adenovirus Ad-ΔE1B19/55, deleted for sequence encoding E1B 19-kDa and E1B 55-kDa proteins, exhibits marked enhancement in cytolytic and apototic activity (Kim et al., 2002). In the current study, we assessed the therapeutic value of Ad-ΔE1B55 and Ad- E1B19/55 in combination with cisplatin. A marked increase in cytotoxicity was observed for both Ad-ΔE1B55 and Ad-ΔE1B19/55 when combined with cisplatin. Relative to each other in all cell lines examined, the combination of the double-deleted adenovirus, Ad-ΔE1B19/55, plus cisplatin exhibited greater cell-killing effect than did the single-deleted adenovirus, Ad-ΔE1B55, plus cisplatin. Propidiun iodide staining and TUNEL assay analysis also revealed that combination of cisplatin with Ad-ΔE1B19/55 caused greater induction of apoptosis than that with Ad-ΔE1B55. Similarly in vivo, the combination of Ad-ΔE1B55 or Ad-ΔE1B19/55 with cisplatin also induced greater antitumor effect in a human cervical xenograft model. TUNEL staining showed that the apoptotic level was significantly higher in tumor tissue treated with Ad-ΔE1B19/55 plus cisplatin than with any other treatment. In addition, viral presence was confirmed by the immunohistological staining with increased numbers of adenoviral particle detected in wider areas of tumors treated with Ad-ΔE1B19/55 oncolytic adenovirus plus cisplatin. Taken together, these findings demonstrate that cisplatin in combination with E1B- 19kD-deleted oncolytic adenovirus may enhance therapeutic efficacy (via active induction of apoptosis), eliciting greater efficacy profile than that with E1B-19kD-expressing oncolytic adenovirus.
Radiation Carcinogenesis
Authors: Henry I. Kohn, R.J. Michael Fry
Journal: New England Journal of Medicine (1984)

DURING the past 10 years, investigators of radiation-induced carcinogenesis in human beings have concentrated on continuing the follow-up of populations previously studied and on collating and reanalyzing all available data. Although these approaches may not seem exciting in comparison to what has been going on in molecular biology, they are essential for two simple reasons. First, there are very few populations suitable for fruitful study, and it is unlikely that additional ones will become available. Second, it has become clear that in many types of cancer, not even 30 years of follow-up are adequate to show the total effect of . . .
Prognostic value of the stress response following stroke
Authors: J. H. Feibel
Journal: JAMA (1977)

The systemic metabolic response following intracranial vascular damage was measured in 65 consecutively seen patients (56 with cerebral infarction and nine with subarachnoid hemorrhage). Significantly (<i>P</i>&lt;.01) greater mortality and eventual disability occurred in patients excreting more than 200 μg of urinary norepinephrine and epinephrine daily early in their acute illness. These patients also had significantly (<i>P</i>&lt;.001) elevated plasma cortisol levels; this measurement may prove useful in predicting prognosis after stroke. Cardiac abnormalities resulting from the elevated catecholamine levels may contribute to the excess mortality in those patients with an intense stress response. (<i>JAMA</i>238:1374-1376, 1977)
Using Geographic Information Systems to Assess Individual Historical Exposure to Air Pollution from Traffic and House Heating in Stockholm
Authors: Tom Bellander, Niklas Berglind, Per Gustavsson, Tage Jonson, Fredrik Nyberg, Goran Pershagen, Lars Jarup
Journal: Environmental Health Perspectives (2001)

A specific aim of a population-based case-control study of lung cancer in Stockholm, Sweden, was to use emission data, dispersion models, and geographic information systems (GIS) to assess historical exposure to several components of ambient air pollution. Data collected for 1,042 lung cancer cases and 2,364 population controls included information on residence from 1955 to the end of follow-up for each individual, 1990-1995. We assessed ambient air concentrations of pollutants from road traffic and heating throughout the study area for three points in time (1960, 1970, and 1980) using reconstructed emission data for the index pollutants nitrogen oxides (NO(x)/NO(2)) and sulfur dioxide together with dispersion modeling. NO(2) estimates for 1980 compared well with actual measurements, but no independently measured (study-external) data were available for SO(2), precluding similar validation. Subsequently, we used linear intra- and extrapolation to obtain estimates for all other years 1955-1990. Eleven thousand individual addresses were transformed into geographic coordinates through automatic and manual procedures, with an estimated error of < 100 m for 90% of the addresses. Finally, we linked annual air pollution estimates to annual residence coordinates, yielding long-term residential exposure indices for each individual. There was a wide range of individual long-term average exposure, with an 11-fold interindividual difference in NO(2) and an 18-fold difference in SO(2). The 30-year average for all study subjects was 20 microg/m(3) NO(2) from traffic and 53 microg/m(3) SO(2) from heating. The results indicate that GIS can be useful for exposure assessment in environmental epidemiology studies, provided that detailed geographically related exposure data are available for relevant time periods.
Outline for Psychiatric Examinations
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Handbuch der Geisteskrankheiten.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuing Education Opportunities for Physicians March through August 1993
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Childhood cancer mortality
Authors: L. A. Sagan
Journal: JAMA (1985)

<h3>In Reply.—</h3> Clinical trials involving childhood cancer have been conducted for decades. We cited four referencesto them, notably in overviews by Levine<sup>1</sup>and Hammond et al.<sup>2</sup>The National Cancer Institute provides almost $10 million annually for clinical trials of childhood cancer by the Children's Cancer Study Group, the Pediatric Oncology Group, the National Wilms' Tumor Study, and the Intergroup Rhabdomyosarcoma Study. Success varies according to the type of cancer treated, with the best results to date obtained for Hodgkin's disease, Wilms' tumor, and acute lymphocytic leukemia. Our study, as stated in the introduction, was meant to determine if the marked improvement observed by collaborating groups or individual cancer centers was also to be found nationwide as evaluated by mortality. We prepared but did not publish a Table to show the close correspondence between the decline in mortality and improved survival as determined by the Surveillance, Epidemiology, and End
Pegylated interferon beta strongly reduces all serological and intrahepatic hepatitis B virus parameters in immunodeficient humanized mice
Authors: Andrea Pirosu, Lena Allweiss, Tassilo Volz, Katja Giersch, Jörg Petersen, Marc Luetgehetmann, Ansgar W. Lohse, Maura Dandri
Journal: Journal of Hepatology (2020)
External validation of clinical prediction models using big datasets from e-health records or IPD meta-analysis: opportunities and challenges
Journal: BMJ (2019)

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Patient outcomes following tricompartmental total knee replacement. A meta-analysis
Authors: C. M. Callahan
Journal: JAMA (1994)

<h3>Objective.</h3> —To provide estimates of patient outcomes following tricompartmental knee replacement and to examine variation in outcomes due to patient and prosthesis characteristics. <h3>Data Sources.</h3> —English-language articles identified through a computerized literature search and bibliography review. <h3>Study Selection.</h3> —Studies were included if they enrolled 10 or more patients at the time of initial knee replacement and measured patient outcomes using a global knee-rating scale. <h3>Data Extraction.</h3> —Each study was subjected to a blinded qualitative assessment and unblinded abstraction of patient characteristics, surgical techniques, and outcomes. <h3>Data Synthesis.</h3> —A total of 130 studies reporting patient outcomes on 154 cohorts satisfied inclusion criteria. The total number of enrolled patients was 9879 with a mean enrollment of 64.1 patients. The mean follow-up was 4.1 years. The mean patient age was 65.0 years, 71.7% of patients were women, 62.6% had osteoarthritis, and 26.6% underwent bilateral knee replacement. Global rating scale scores improved by 100% for the typical enrolled patient, and 89.3% of patients reported good or excellent outcomes. Anatomic classification of the prosthesis, percentage of enrolled patients with osteoarthritis, publication year, and number of enrolled patients explained 27% of the variation in reported mean postoperative global rating scale scores. The weighted mean complication rate was 18.1%, and the mean mortality rate per year of follow-up was 1.5%. The overall rate of revision during 4.1 years was 3.8%. <h3>Conclusions.</h3> —Tricompartmental knee replacement was a safe and effective procedure for the patients reported in these studies. The knee pathology and the type of prosthesis were significant predictors of outcomes. Limitations in the reporting style of these articles severely constrain the ability to explore variation in outcomes due to study, patient, or prosthesis characteristics and restrict their generalizability. (<i>JAMA</i>. 1994;271:1349-1357)