tbuckley/cabot-search huggingface dataset:
BACILLUS ACIDOPHILUS THERAPY
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combined Modalities: Chemotherapy/Radiotherapy
Journal: JNCI Journal of the National Cancer Institute (1978)

Combined Modalities: Chemotherapy/Radiotherapy Get access JNCI: Journal of the National Cancer Institute, Volume 60, Issue 5, May 1978, Page 1184, https://doi.org/10.1093/jnci/60.5.1184-b Published: 01 May 1978
Arthrogryposis syndrome (Kuskokwim disease) in the Eskimo
Authors: J. H. Petajan
Journal: JAMA (1969)

A new syndrome of congenital skeletal abnormalities has been found in the Alaskan Eskimo. The condition is characterized by multiple joint contractures predominantly affecting the knees and ankles, with atrophy or compensatory hypertrophy of associated muscle groups. Intellectual functioning is not impaired, and, aside from the skeletal system and possibly the skin, there are no other consistent physical anomalies. General laboratory studies disclosed no abnormality, extensive electromyographic investigation showed no basic defect of the motor unit, and results of muscle biopsies were normal. Treatment to date has been entirely orthopedic, with use of surgery, casting and bracing, and passive manipulation. This condition can be separated from the heterogeneous category of arthrogryposis multiplex congenita by its distinctive clinical features and by the familial pattern of distribution, which suggests an autosomal recessive mode of inheritance.
LIBRARY WANTS AND SUPPLIES.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Normal electrocardiographic variants simulating ischemic heart disease
Authors: H. J. Marriott
Journal: JAMA (1967)

The partnership of an electrocardiograph and an unskilled, or perhaps overconfident, interpreter can be a threat to life and limb. The most serious harm is done when the clinical context of a normal variant is disregarded and, with overreliance on the tracing itself, coronary or myocardial disease is pronounced.<sup>1</sup>This may turn a normal person into a cardiac-disease cripple. At least one instance of suicide resulting from the effects of misinterpretation has been reported,<sup>2</sup>and I have personally encountered the following socioeconomic consequences: unnecessary hospitalization with resulting serious financial embarrassment, cardiac-disease neurosis, denial of needed life insurance, postponement of marriage.<sup>3</sup>Such miscarriages of diagnostic justice can cause serious and lasting dislocations in our patients' lives, and so it is clearly the duty of everyone who presumes to interpret electrocardiograms to know the limitations of electrocardiography—or rather, we must fully appreciate our own limitations as interpreters. What is
Medical Economics
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract B11: Development of orthotopically grafted organoid models to study pancreatic cancer progression
Authors: Chang-Il Hwang, EunJung Lee, Tobiloba Oni, Youngkyu Park, David A. Tuveson
Journal: Cancer Research (2016)

Abstract Pancreatic ductal adenocarcinoma (PDA) is one of the most difficult human malignancies to treat. The 5-year survival rate of PDA patients is 7% and PDA is predicted to become the second leading cancer-related cause of death in the USA. A subset of potential tumor suppressor (Ts) genes was identified by genome-wide analysis of human PDA and insertional mutagenesis in genetically engineered mouse models (GEMMs). Since the functional validation of these genes in GEMMs is time-consuming and labor-intensive, we have developed a rapid and efficient “orthotopically grafted organoid’ (OGO) models in conjunction with RNAi and CRISPR/Cas9 technology to study PDA progression. Previously, we showed that OGO model represents the full spectrum of PDA progression in vivo upon orthotopic engraftment. Here, as a proof-of-concept experiment, we demonstrate that ablation of Trp53 by shRNA or gRNA in PanIN-derived organoids accelerates PDA progression upon transplantation. Therefore, OGO models should provide an excellent platform to study the functional role of genes in PDA progression in vivo. Note: This abstract was not presented at the conference. Citation Format: Chang-Il Hwang, EunJung Lee, Tobiloba Oni, Youngkyu Park, David A. Tuveson.{Authors}. Development of orthotopically grafted organoid models to study pancreatic cancer progression. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2016 May 12-15; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(24 Suppl):Abstract nr B11.
Pharmacotherapy and Risk of Suicidal Behaviors Among Patients With Bipolar Disorder
Authors: Boghos I Yerevanian, Ralph J Koek, Jamie D Feusner
Journal: JAMA (2004)

To the Editor: In their retrospective study, Dr Goodwin and colleagues1 reported that lithium was associated with a lower risk of suicide attempt and suicide death than was divalproex among patients with bipolar disorder.
Environmental radioactivity
Authors: Eugene L. Saenger
Journal: JAMA (1963)

With the possibility of continued weapons-testing, the ever-present specter of nuclear warfare, and the continuing growth of nuclear power, concern about environmental radiation will increase in the next two decades. Most physicians lack a clear understanding of this group of problems and of their responsibilities in respect to them. Eisenbud, who has been actively working in all aspects of this field known as health physics, presents the first clear, succinct text discussing these subjects. To understand all of the ramifications of these problems he combines a background of physics, meteorology, radiochemistry, radiobiology, and nuclear technology in the book. Of least interest to physicians is the section on radiation effects on man, which is purposely oversimplified and well covered elsewhere. The chapters covering atmospheric transport of radionuclides, their passage through food chains and water, and the various uses of nuclear energy in industry, as well as the consequences of warlike activities
Granuloma fissuratum
Authors: M. Tanenbaum
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The article entitled "Permanent Alopecia From Pressure of a Head Strap" (<b>199</b>:747, 1967) was of considerable interest. It is noted, however, that the age of the patient was 4 years and the duration of the anaesthetic 6 1/2 hours. Hence, I feel that in similar cases the answer is not in more careful positioning of the head strap, but rather a change in anaesthetic technique: to use an appropriately sized pediatric orotracheal tube (to reduce dead space) and low-resistance circle or high-flow open anaesthetic circuit. Further, in such a young patient and an operation lasting as long as this, a case can be made for intermittent positive pressure ventilation with use of tubocurarine or halothane to depress respiration. This would ensure maintenance of favorable oxygen and carbon dioxide arterial gas tensions and prevent respiratory acidosis. Further, oxygen consumption would be reduced and the child would be
* Soluble plantain fibre blocks epithelial adhesion and M-cell translocation of intestinal pathogens
Authors: C. L. Roberts, A. V. Keita, B. N. Parsons, M. Prorok-Hamon, P. Knight, N. O'Kennedy, J. D. Soderholm, J. M. Rhodes, B. J. Campbell
Journal: Gut (2011)

<h3>Introduction</h3> Dietary fibres may have prebiotic effects mediated by promotion of probiotic bacteria. This study explores the possibility that they may also improve health by inhibiting epithelial adhesion and translocation by pathogenic bacteria. We have focussed on soluble non-starch polysaccharide (NSP) from plantain bananas (<i>Musa</i> spp) since previous studies had shown that this is particularly effective at blocking <i>Escherichia coli</i> epithelial adherence. <h3>Methods</h3> The ability of plantain NSP to inhibit epithelial cell adhesion and invasion of various bacterial pathogens, their translocation through microfold (M)-cell monolayers (generated by co-culture of Caco2-cl1 cells and Raji B cells) and human Peyer9s patches mounted in Ussing chambers has been assessed. <h3>Results</h3> Plantain NSP showed dose-related inhibition of epithelial adhesion and M-cell translocation by a range of gut pathogens. Plantain NSP at 5 mg/ml, a concentration readily achievable in the human gut lumen, inhibited adhesion to Caco2 cells of <i>Clostridium difficile</i> (67.6±12.3%, p&lt;0.001 ANOVA), <i>Salmonella</i><i>typhimurium</i> (85.0±8.2%, p&lt;0.01), <i>Shigella sonnei</i> (46.6±29.3%, p&lt;0.01) and<i></i> ETEC (56.1±23.67%, p&lt;0.05) but did not inhibit EPEC adhesion. Plantain NSP (5 mg/ml) also inhibited invasion of Caco2 cells by <i>Salmonella</i> (80.2±9.7%) and <i>Shigella</i> (46.7±13.4%; both p&lt;0.01). Blockade of adherence and invasion to Caco<sub>2</sub> cells by plantain NSP was also confirmed by Giemsa stain and light microscopy. Plantain NSP, at 5 mg/ml, also inhibited translocation of <i>Salmonella</i> and <i>Shigella</i> across M-cells by 46% and 73% respectively (both P&lt;0.01). Similarly, blockade of <i>Salmonella</i> translocation across follicle-associated epithelium (FAE) of human ileal Peyer9s patches was observed with 5 mg/ml plantain NSP (p&lt;0.01; N=3). <h3>Conclusion</h3> Soluble plant fibre from plantain bananas inhibits invasion and adhesion of pathogenic bacteria to Caco2 cells, and their translocation across M-cells of the FAE. This represents a novel mechanism by which soluble dietary fibres could promote intestinal health and prevent infective diarrhoea.
Hypertension
Authors: Dorothea Loofbourow, Robert S. Palmer
Journal: New England Journal of Medicine (1950)

PROGRESS in hypertension has not been reported in this section before, although certain forms of treatment have been discussed. It has been our endeavor to describe, in the first place, the general progress that has been made in the field and, secondly, the recent investigative work. To accomplish this we have organized the material as follows: general etiologic theories, recent investigative work, recent work in pathology, treatment, and the natural history and evolution of essential hypertension derived from follow-up studies.EtiologyProgress in the knowledge of hypertension may be considered to have taken place in hundred-year cycles: Harvey discovered the . . .
Etiology of Keratoacanthoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
Authors: Florian P. Limbourg, Zhihong Huang, Jean-Christophe Plumier, Tommaso Simoncini, Masayuki Fujioka, Jan Tuckermann, Günther Schütz, Michael A. Moskowitz, James K. Liao
Journal: Journal of Clinical Investigation (2003)
Antileprosy drugs.
Authors: A S Garrett
Journal: BMJ (1971)

nodes.This may well link up with the work done by Hawley et al.2 and Paile5 suggesting that some patients may do better because their cellular immune mechanisms are putting up resistance to the primary, and they may do well even if some metastases have reached a few local nodes.This is an important problem, because the surgeon at laparotomy who finds some palpable nodes near a resectable gastric tumour may well decide against radical local dis- section on the basis of an apparently hopeless prognosis ("glandular metastases").My study showed that where surgeons reported "malignant glands present," the histological findings in no less than 1: 3 patients were of OX or LTH status (and therefore a better prognosis).In other words, there are two reasons to continue with radical lymphatic surgery, even with palpable nodes.Firstly, they may be benign, and secondly, they may represent the minimal invasion and quite good prognosis situation.For those who can stand awful doggerel this may be sum- marized: "All that bulge are not maligne, Even be some so, do not pyne."May I also point out the fact that early diagnosis of gastric cancer, and greatly im- proved results in treatment, have been taken a stage further by the use of gastric cytology, with or without fibrescope collecting methodS.6 7-I am, etc.,
From the NIH: a look at the management of psoriasis
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pegylated Interferon vs Standard Interferon for Chronic Hepatitis C—Reply
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Syndrome of Papillary Muscle Dysfunction: Its Clinical Recognition
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parallel 32: Clinical Aspects of HCV Virology, Pathogenesis, and Immunology
Journal: Hepatology (2015)

Background: In the United States, there are limited treatment options for liver transplant recipients with recurrent HCV and advanced fibrosis/cirrhosis.In a Phase 3 study, the pangenotypic combination of daclatasvir (DCV) and sofosbuvir (SOF) with ribavirin demonstrated SVR rates of 94% in liver transplant recipients with HCV recurrence.This analysis reports interim findings from a U.S. Treatment Use protocol in patients with recurrent HCV following liver transplantation and advanced fibrosis or cirrhosis.Methods: In this multicenter, open-label, expanded access study, DCV was provided for use in combination with SOF, with or without RBV at the investigator's discretion, for up to 24 weeks in genotype 1-6 patients with F3 fibrosis, cirrhosis, or fibrosing cholestatic hepatitis (FCH) following liver transplantation.The HCV TARGET consortium of academic and community medical centers and data collection methodology were utilized.This interim analysis includes 51 patients who have enrolled and initiated treatment at 20 sites.Results: Of the 51 patients treated, 49 received DCV+SOF and 2 received DCV+SOF+RBV.Patients were predominantly male (77%), white (82%) and infected with HCV genotype 1 (73%) or genotype 3 (24%).Fifty-seven percent had failed prior treatment with IFN-based regimens (12% included a protease inhibitor).Cirrhosis was present in 82% of patients, including 57% with evidence of post transplant hepatic decompensation, 8% had a kidney transplant, and 8% had FCH.At baseline, median HCV RNA was 2.9 x 10 6 IU/ml, the mean (range) for platelets was 129 (41-239) x10 3 cells/uL, albumin 3.4 (1.7-6.3)g/dL, total bilirubin 1.5 (0.3-13) mg/dL, INR 1.1 (1.0-1.5), and creatinine clearance was 83 (40-190) ml/min.MELD was ≥10 in 48% of patients with available scores.Of 21 patients with available data, the end of treatment virologic response was 100%.All four patients who reached post-treatment week 12 achieved SVR.Adverse events occurring in ≥10% of patients were fatigue, headache, nausea, and arthralgia.Serious adverse events of interest included transplant rejection (n=1) and renal failure (n=4).Two patients discontinued treatment for adverse events; 1 due to renal failure leading to death (unrelated to treatment) and 1 due to death of unknown cause.SVR results for 31 patients will be available for presentation.Conclusion: DCV+SOF for 24 weeks was well-tolerated in this population with severe recurrent post-transplant hepatitis C. Interim data indicate effective end of treatment antiviral response and SVR in the patients receiving this regimen through compassionate use.
Reply
Authors: J M Rhodes, I A Finnie
Journal: Gut (1994)

clusions can be drawn from specimens taken from only six patients of whom two had ileostomies.The results show a coefficient of variation of about 50% and the risks of a type 2 statistical error must be very high.In conclusion it is important that Finnie et al suggest an explanation as to why they found such a low protein weight to wet weight ratio.Until they do so it is very difficult to interpret their data.