tbuckley/cabot-search huggingface dataset:
Who is minding the world?
Authors: R. J. Joynt
Journal: JAMA (1994)

The power of the president of the United States is unparalleled, so concerns about the physical and mental health of the incumbent are and should be of major concern. There are several reasons for these concerns with any leader, but some are specific to the president. First, the schedule of business, entertaining, and travel is exhausting and stressful. The travel may be over several time zones with the attendant problem of jet lag and disrupted sleep patterns. Second, the president is a frequent target of assassins. Third, the position and authority of the staff are dependent on the continuing and active presence of the president. They would be loathe to point out personal frailties to the incumbent and to make these frailties known to the public. There are several instances of this, the most prominent being that of President Wilson. Post and Robins,<sup>1</sup>writing about the effect of illness
OPPORTUNITIES FOR GRADUATE MEDICAL EDUCATION IN EUROPE
Journal: JAMA (1921)

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Paternal immunoglobulin abnormalities in congenital hypogammaglobulinemia
Authors: C. H. Kirkpatrick
Journal: JAMA (1967)

The serums of relatives of male children with hypogammaglobulinemia were examined for the content of immunoglobulins. In three instances the concentration of IgM was low in the fathers and in two of these cases the same abnormality was also found in the paternal grandfathers. In a fourth family the father had generalized hypogammaglobulinemia and the paternal grandmother had a low concentration of IgM. Abnormalities were not found in the mothers. These observations suggest a role for paternal genetic factors in the inheritance of some forms of hypogammaglobulinemia. Although the number of cases studied to date is small, it is possible that these abnormalities may identify the male carrier of this disorder and facilitate genetic counseling.
SETTING THE BEST EXAMPLES
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Report of the Council on Medical Education
Journal: JAMA (1964)

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Low Levels of Procalcitonin or Presepsin Combined with Significantly Elevated C-reactive Protein May Suggest an Invasive Fungal Infection in Hematological Patients With Febrile Neutropenia
Authors: Igor Stoma, Igor Karpov, Anatoly Uss, Svetlana Krivenko, Igor Iskrov, Natalia Milanovich, Svetlana Vlasenkova, Irina Lendina, Kristina Belyavskaya, Veranika Charniak
Journal: HemaSphere (2019)
Extensible bandages.
Authors: S. Thomas
Journal: BMJ (1992)

health education increased the uptake of screening among Asian women in Leicester, McAvoy and Raza found that written material sent by post was ineffective.'It is labour intensive to educate women to accept screening services.Secondly, medical staff need training to differentiate normal and abnormal cervices by visual inspection, particularly as inspection may not be sensitive and specific enough to detect early cancer owing to the range of aberrant normal cervices.Many false positive diagnoses may result and undue anxiety be caused if definitive diagnoses cannot then be made owing to lack of resources.Finally, direct inspection ofthe cervix is possible only in health centres with a room, couch, proper lighting, and speculums.Facilities and equipment are likely to be inadequate owing to lack of finance.Developing countries should invest in the health of the population instead of fighting wars and shift their priorities towards the health and social welfare of people.Direct visual inspection of the cervix to detect early cervical cancer may be useful in some centres but is not viable for population screening of women in developing countries.
FOOD AND SATIETY
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HOW NOT TO BE NERVOUS.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AGATA molecular screening program: Implementing precision medicine in patients with advanced breast cancer in Spain
Authors: S. Pernas Simon, P. Villagrasa Gonzalez, A. Vivancos, A. Prat, M. Scaltriti, O. Burgues, J. Rodon, J. Canes, A. Lluch, A. Llombart, J. Dorca, A. Perelló Martorell, M. Oliveira, A. Montaño, L. Garcia-Estevez, P. Nuciforo, G. Ribas, I. Rapado, L. de la Pena, E. Ciruelos
Journal: Annals of Oncology (2017)
P127 (0126) AUTOLOGOUS (AUTO‐HCT) AND ALLOGENEIC STEM CELL TRANSPLANTATION (ALLO‐HCT) IN THE MANAGEMENT OF RELAPSED/REFRACTORY (RR) HODGKIN LYMPHOMA (HL). A RETROSPECTIVE ANALYSIS OF THE LYMPHOMA WORKING PARTY OF THE EBMT
Journal: HemaSphere (2018)
The Health of the Mind.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Military Physicians
Authors: Mary C. Gillett
Journal: JAMA (1978)

<h3>To the Editor.—</h3> As a historian for the Medical History Division of the army's Center of Military History, I read the editorial, "Civilian Physician Contribution to the Active Military" (238:1952, 1977), with interest, especially because I have recently completed the manuscript for a volume to be entitled<i>The Army Medical Department, 1775-1818</i>and am now starting work on a volume designed to cover the work of the Medical Department from 1818 to 1865. While I certainly have no quarrel with the author's thesis, I believe that the text and the accompanying graph are misleading as far as the period from 1775 to 1865 is concerned. The graph leaves the erroneous impression that, except for contract surgeons serving during the Civil War, all surgeons with the army were members of the militia, while the text suggests that until World War I there were few, if any, career military surgeons in the
Drug Formulas Transposed.
Journal: JAMA (1975)

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THE PROPER RECOGNITION OF THE LABORATORY TECHNICIAN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fluid and electrolyte balance during acute withdrawal in chronic alcoholic patients
Authors: J. D. Beard
Journal: JAMA (1968)

Total body water, extracellular volume, and plasma volume were measured in 30 well-nourished, chronic alcoholics. Plasma and erythrocyte electrolyte concentration and excretion were measured. Isosmotic overhydration with normal concentrations was found on admission to the hospital. With no specific fluid or electrolyte therapy, total body water level decreased to normal four days later. Abnormal liver function was found in all patients. Empirical and ubiquitous use of fluids in alcoholics, presumed to be dehydrated, may only exacerbate overhydration.
Report of the President
Authors: Walter G. Phippen, Henry R. Viets
Journal: New England Journal of Medicine (1948)

IN accordance with a long established custom it is my privilege to submit my second annual report as president of the Boston Medical Library.Since our last annual meeting the active participation of the Massachusetts Medical Society in the affairs of the Library has become a fact. Every member of the Massachusetts Medical Society in good standing is now a Society member of the Library entitled to all the rights and privileges, except the right to vote, which by virtue of our charter is vested solely in the fellows. The Society allots $5.00 of each member's dues toward the maintenance . . .
THE QUADRENNIAL ELECTION.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P041: Glucose Rise on Statins in Older Age: Adaptive Protection Against Fatigue?
Authors: Beatrice A Golomb
Journal: Circulation (2013)

Background: We previously showed that statins increase a composite fatigue measure; and that statins increase glucose preferentially in those over age 55 - increasingly with each decade, particularly in presence of risk factors for impaired bioenergetics. We speculated that glucose elevations may be adaptive defenses of cell energy, and assessed whether greater glucose elevations on statins, in those over age 55, were linked to lesser risk of fatigue on statins. Method: 1016 participants age &gt;20 were randomized equally to simvastatin 20mg, pravastatin 40mg or placebo. Baseline and 6mo (on-treatment) glucose (mg/dL) were assessed and glucose change calculated. The fatigue change measure, summed self-rated changes in exertional fatigue and in energy (aligning signs). Regression assessed the relation of glucose-change to fatigue change (using the continuous glucose measure as the dependent variable), adjusted for baseline glucose, stratified by treatment. Results: As age advanced, glucose change over 6 months showed increasing inverse associations with fatigue change, on statins and particularly simvastatin ( Table ). Qualitatively similar tendencies on placebo did not reach significance. Discussion: Greater glucose rise in older age, particularly on statins, was linked to lesser fatigue and exertional-fatigue symptoms, with potential implications for function. We speculate that glucose rise e.g. in older age/ on statins may represent a physiological adaptation to protect against bioenergetic insufficiency.
A phase 1b study of the anti-PD-1 monoclonal antibody BGB-A317 (A317) in combination with the PARP inhibitor BGB-290 (290) in advanced solid tumors.
Authors: Michael Friedlander, Tarek Meniawy, Ben Markman, Linda R. Mileshkin, Paul R. Harnett, Michael Millward, Joanne Lundy, Alison E. Freimund, Christie Norris, Song Mu, John Wu, Virginia E. Paton, Lai Wang, Bo Gao
Journal: Journal of Clinical Oncology (2017)

3013 Background: The release of tumor-associated antigens may enhance the response to immunotherapy. BGB-A317, a humanized IgG4 variant monoclonal antibody engineered to have no Fc gamma receptor binding, targets the programmed cell death-1 (PD-1) receptor. It is being developed in solid and hematologic malignancies at a dose of 200 mg IV Q3W. BGB-290, a potent inhibitor of PARP 1/2, is hypothesized to promote neoantigen release that will potentially increase the efficacy of BGB-A317. A phase 1 study identified 60mg BID as the recommended Phase 2 dose (RP2D) for BGB-290. This study consists of initial dose escalation to determine the maximum-tolerated dose (MTD), safety, PK profile, and preliminary anti-tumor activity of the combination, followed by expansion into ovarian, breast, prostate, gastric, bladder, pancreatic and small cell lung cancers. Methods: Cohorts of 6 -12 pts with advanced solid tumors were treated in each of 5 planned dose levels (DLs). In DLs 1-3, BGB-290 doses ranged between 20-60mg PO BID with BGB-A317 2mg/kg IV Q3W. In DLs 4 - 5, BGB-290 doses were 40 or 60 mg BID; A317 was given at 200 mg IV Q3W based on PK data from a single agent Phase 1 study. Results: As of 16 Jan 2017, 38 pts [median age 59 years (34-75)] were treated in DLs 1-4; enrollment to DL5 is ongoing. One DLT of persistent Gr 2 nausea was reported in DL 4. The most common adverse event (AE) considered related to both study drugs was fatigue (10.5%). Immune-related AEs were Gr 3 hypophysitis (n = 1), Gr 3 or 4 autoimmune hepatitis(n = 2), and Gr 2 elevated AST/ALT (n = 1). Decreases in tumor burden have been observed in 16 pts; 7 achieved a PR (5 with ovarian and one each with uterine and pancreatic cancer) and one CR was observed in ovarian cancer. Six pts had SD for &gt; 6 months including 2 pts with pancreatic cancer who received BGB-A317+BGB-290 for 189 and 281 days. Plasma/serum exposure of BGB-290 and BGB-A317 were consistent with those in single-agent trials. Conclusions: BGB290 and BGB-A317 can be combined. Dose expansion in multiple tumor types is planned to commence in 2017 once the RP2D is determined. Clinical trial information: NCT02660034.