tbuckley/cabot-search huggingface dataset:
Cost containment through medical education
Authors: I. Praiss
Journal: JAMA (1980)

Efforts for containing the costs of health care are currently being directed primarily toward the organization and administration of health care services, and there is increasing legislation pertaining to the financing and reimbursement for medical care. An important area that to date has received insufficient attention as an approach to cost containment is the process of medical education and the training of young physicians. A curriculum on the economic dimensions of medical practice is proposed, and principles for instituting the curriculum are detailed. Such a curriculum would highlight cost-consciousness without compromising the quality of care. The establishment of teaching programs and the development of cost-conscious clinical settings are presented as major challenges to medical schools. (<i>JAMA</i>244:53-55, 1980)
Prospective trial of operative versus non-operative treatment of severe vesicoureteric reflux in children: five years' observation. Birmingham Reflux Study Group.
Authors: J Corkery, P Gornall, C Taylor, David Evered, Joe Anderson, Patricia Griggs
Journal: BMJ (1987)

Children with severe vesicoureteric reflux were allocated randomly to either operative or non-operative treatment and followed up. Altogether 161 children were observed for two years, of whom 104 were followed up for five years. Reflux was abolished in 98% of ureters reimplanted, but more than half of the patients treated non-operatively continued to show severe reflux at five years. Two patients progressed to end stage renal failure, and a further four with extensive bilateral renal scarring became hypertensive. There were no significant differences between treatment groups in the incidence of breakthrough urinary infection, renal excretory function and concentrating ability, renal growth, progression of existing renal scars, or new scar formation. Progressive scarring occurred at all ages but was significantly more common during the first two years' observation. Furthermore, new scars developed exclusively during the first two years' observation, affecting 10 children aged 2-7 at allocation. Neither treatment can claim superiority or fully protect the kidneys from further damage, and efforts must continue to be directed towards identifying those at risk before scarring develops.
POISONING FROM ACCIDENTAL INGESTION OF MEDICINAL IRON
Journal: JAMA (1952)

Veeder recently reviewed eight fatal and eight nonfatal cases of accidental poisoning in young children from the ingestion of medicinal iron, usually ferrous sulfate, that were reported in the past four years.<sup>1</sup>Four cases, three of them fatal, were reported in the British literature in 1947.<sup>2</sup>Since then 14 additional cases have appeared in the foreign and American literature.<sup>3</sup>These poisonings indicate that physicians must adopt a more cautious attitude toward these iron preparations. They have long been looked upon as relatively innocuous, and, prior to 1947, few cases of accidental poisoning from iron preparations had been reported. It was impossible in many cases to determine the actual amount of iron preparation ingested, but the quantity in each case was probably grossly excessive. Shortly after the ingestion of ferrous sulfate tablets, a fairly typical group of symptoms was seen in almost all cases, including bloody vomiting, shock,
The Relationship between Fibrosis and Cancer in Experimental Animals Exposed to Asbestos and Other Fibers
Authors: John M. G. Davis, Hilary A. Cowie
Journal: Environmental Health Perspectives (1990)

The association between occupational asbestos exposure and the development of both pulmonary fibrosis or asbestosis and pulmonary carcinomas is well documented. It has been suggested that the two pathological conditions are associated with asbestos-related carcinomas developing from areas of asbestosis and not occurring when exposure has been too low to produce this type of pulmonary scarring. Experimental inhalation studies so far published have not been designed to examine this association specifically, but many publications have reported that asbestos samples producing high levels of fibrosis is experimental animals are also very carcinogenic. Samples of asbestos or man-made fibers that produce little fibrosis also produce few tumors. These works are reviewed. In order to examine the association between fibrosis and tumor production in more detail, groups of animals with and without pulmonary tumors and with individual fibrosis measurements were assembled from a number of inhalation studies undertaken over a period of years at this Institute. It was found that animals with pulmonary tumors had almost double the amount of pulmonary fibrosis as animals of similar age that did not. In a few of the animals where tumors were found at an early stage of development, their origin from fibrotic areas could be confirmed, although in most cases where tumor deposits were widespread this was not possible. Experimental confirmation of the site of origin of most pulmonary tumors in asbestos-treated rats would require new studies with rats examined specifically at an age when early tumors would be expected.
Adequate enzyme replacement after total pancreatectomy
Authors: A. Robert
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Two years ago, at age 60 years, I developed multifocal adenocarcinoma of the pancreas. The only signs were some abdominal discomfort 2 to 3 hours after meals, two bowel movements per day instead of one, and softer stools. They persisted for about 3 weeks. Then, jaundice (without pain) was noticed by a colleague 1 week prior to hospitalization. The surgical treatment consisted of Whipple's operation (total pancreatectomy, duodenectomy, gastrojejunostomy, splenectomy, and cholecystectomy). Quite a job. This was followed by chemotherapy (fluorouracil, doxorubicin [Adriamycin], and mitomycin) and abdominal radiation. The pancreatectomy produced instant type I diabetes and total lack of digestive enzymes. To compensate for the latter, I first took three capsules of pancrelipase (Pancrease) before each meal. Later on, I switched to pancreatin and then Entolase HP. The insulin doses have been 20 U of insulin zinc suspension (Lente insulin) in the morning and 7 U of
Hemodialysis coil reuse. A safe and economical new method
Authors: R. T. Bilinsky
Journal: JAMA (1971)

An effective coil reuse procedure can substantially reduce the cost of long-term hemodialysis treatment. A simple, safe, and inexpensive method is described which permits coil saving for at least nine reuses. Sterile water is infused rapidly through the blood path. The tubing is then sealed and cut. The coil is stored in a 27% sodium chloride solution. Chemical and bacteriological monitoring for more than one year (3,200 hemodialyses) has revealed no compromise of sterility or membrane integrity. Significant fibrin deposits occurred in only 2% of the reused coils, and contamination due to errors in technique accounted for less than 1% of discarded coils. Use of this method resulted in a significant reduction in the cost of the most expensive disposable item used in hemodialysis.
"GAS CYSTS OF THE ABDOMEN"
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Authors: Burton M. Needles
Journal: Journal of Clinical Oncology (1995)

To the Editor: I am writing to alert readers to a dosing error in the book, The Chemotherapy Handbook, published and distributed by Cerenex Pharmaceuticals. On page 85, in the Urogenital Cancer section, the correct bleomycin dose for the bleomycin/etoposide/ cisplatin regimen is 30 U total dose rather than 30 U/m 2 .
Medical Economics
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UNSATISFACTORY REFERENCES BY ANTIVIVISECTIONISTS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply:
Authors: Olle Ringdén
Journal: Journal of Clinical Oncology (2005)

We have read with great interest the article by Ringden et al, 1 who reported on the risk of graftversus-host disease (GVHD) and death in patients with acute leukemia receiving granulocyte-colony-stimulating factor (G-CSF) after allogeneic bone marrow (BM) transplantation.In this retrospective analysis, patients received bone marrow or peripheral blood stem cells (PBSC), and were administered phrophylatic G-CSF post-transplantation.An increase in GVHD and treatment-related mortality (TRM) was observed only in patients receiving G-CSF after BM transplantation.Similarly, overall and leukemia-free survival rates were significantly reduced (relative to control risks: 0.59, P Ͻ .0001;0.64, P ϭ .0003,respectively).The results of this study differ from the recently published meta-analyses examining the effect of growth factors on GVHD after allogeneic transplantation. 2 In addition, as discussed in the accompanying editorial, there were significant differences between the two arms in terms of patient characteristics, GVHD prophylaxis, and disease stage.However, although the authors emphasized the possibility of center effect or bias and discussed their rationale in disregarding interpatient or interstudy variability, no clear hypotheses to explain the negative effects of G-CSF in the GVHD-sensitive cohort were mooted.There are fundamental differences in the leukocyte profiles of PBSC and BM that need to be considered, which could explain the differences in response to G-CSF.It is already known that 85% of PBSC are composed of granulocytes that undergo apoptosis more readily. 3Therefore, G-CSF would have minimal effects on these cells.Conversely, BM is rich in pluripotent cells highly expressing functional G-CSF receptors, and would respond to the ligand more effectively.This could easily promote the immunogenic cells responsible for the GVHD.We have recently reported granulocyte-macrophage colony-stimulating factor, a growth factor with similar function and target to G-CSF 4,5 that could potentiate antiapoptotic function in cells expressing the receptor, thereby maintaining the cell viability. 6Consequently, it would have been useful to know the G-CSF receptor expression of the bone marrow and PBSCs.It is intriguing to speculate that G-CSF-mediated GVHD was compounded by this feature.
Neurotransmitter Receptors And Phosphoinositide Turnover
Authors: D. Chuang
Journal: The Annual Review of Pharmacology and Toxicology (1989)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
CIRCULATING ANTINUCLEAR GLOBULINS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Max Beckmann
Authors: E. F. Schmerl
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Your recent AMAgram cover story on the illustrious German expressionist painter, Max Beckmann, was inspired by his painting "Birth" (<b>217</b>:263, 1971). It accompanied the article on "Pregnancy Following Closed Mitral Valvuloplasty." I wish to add an interesting little item of cultural medicine, which is perhaps germane to your story and which is based on my own direct observation. Max Beckmann's father was a prominent obstetrician in the city of Leipzig, the painter's hometown. He practiced in his busy "Privatklinik" close to their home. Undoubtedly the impressionable young "avid sketcher" had lots of exposure to birth.
Increased 18F-2- Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma
Authors: Xin Cheng, Wenjia Zhu, Ruixue Cui
Journal: Clinical Nuclear Medicine (2017)

Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; National Natural Science Foundation of China [email protected]. Received for publication March 25, 2017; revision accepted March 31, 2017. Conflicts of interest and sources of funding: none declared.
Pacemaker-induced ventricular tachycardia. Reversion to normal sinus rhythm by carotid sinus massage
Authors: D. Lorentzen
Journal: JAMA (1976)

PARASYMPATHETIC action in influencing electrophysiologic events in the ventricles has been debated. We report a case of ventricular tachycardia produced by a transvenous catheter pacemaker. The tachycardia was twice converted by left carotid massage, implying parasympathetic action in the ventricle. <h3>Report of a Case</h3> A 56-year-old woman was admitted to the hospital for pelvic laparotomy for an adnexal mass. She was also to have upperabdominal exploration at surgery and possible gastric surgery because of an abnormality on roentgenograms. She had a history of mild hypertension and was being treated with methyldopa (250 mg twice daily) and a spironolactonehydrochlorothiazide combination (Aldactazide) twice daily. During preoperative assessment, she had normal complete blood cell count (CBC), creatinine clearance, and serum electrolyte levels. However, her ECG showed intermittent sinus bradycardia, periods of sinus arrest with junctional escaped beats, and, at times, apparent 2:1 sinoatrial exit block. No symptoms suggestive of bradycardia were reported, and
Contents, Vol. 47, No. 3-4, 1987
Authors: F.H. Roldan, H. Warnes, J. Blustein, Herbert Weiner, Zbigniew J. Lipowski, Juan J. López-Ibor, Cairns Aitken, Giovanni A. Fava, Thomas N. Wise, Walter Vandereycken, A. Singer, S. Thompson, C. Kraiuhin, E. Gordon, G. Howe, A. Howson, R. Meares, Leigh James, Andrew Singer, Yvonne Zurynski, Evian Gordon, Claudia Kraiuhin, Anthony Harris, Alan Howson, Russell Meares, Vincenta Leigh, Sue Smolski, H.R. Winefield, A.H. Winefield, M. Tiggemann, S. Smith, Adam J. Krakowski
Journal: Psychotherapy and Psychosomatics (1987)
Examining Product Risk in Context: The Case of Zomepirac-Reply
Authors: Dennis Ross-Degnan
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr Spielberg suggests that the manufacturer's warning letter to physicians regarding the risk of zomepirac was worded ambiguously to soften its impact. He states that this was an important factor in the failure to affect prescribing habits. We are not as sanguine, however, about the effectiveness of even more accurate and persuasive printed informational materials, used alone, in changing physician behavior. Data from four large and well-controlled trials strongly indicate that while mailed drug information may increase knowledge temporarily, it generally has little or no effect on prescribing behavior, unless it is supplemented by face-to-face communications, or heavy reporting of toxic effects by television, radio, and other media.<sup>1</sup> Dr Musa's letter implies that because the withdrawal of a new agent may lead to a return to the use of older, suboptimal therapies (that would have continued without introduction of the new drug), there is "no net effect."
PRELIMINARY QUARANTINE.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Controversy in medicine: access to employee health records
Authors: J. Elliott
Journal: JAMA (1979)

Whatever, in connection with my professional practice, or not in connection with it, I may see or hear in the lives of men which ought not to be spoken abroad, I will not divulge, as reckoning that all such should be kept secret.—The Oath of Hippocrates The complex and often bitter debate over who shall have access to employee medical records will reach a denouement within the next several months as the Occupational Safety and Health Administration (OSHA) ponders the final details of a new set of regulations in this area. The proposed OSHA regulations, while pertaining only to employee medical records, may well mark the beginning of a tumultuous upheaval in the traditional handling of all medical records. In addition, several signs indicate that Congress is primed to tackle the records confidentiality issue in the present session. Senate bill 3450, along with House of Representatives bill 13994, both
Radiological Diagnosis of Extra-Uterine Pregnancy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal