tbuckley/cabot-search huggingface dataset:
Small-Bowel Endoscopy
Authors: F P Rossini, M Pennazio
Journal: Endoscopy (2000)

During the last year, several interesting publications have further confirmed the role of enteroscopy in clinical practice. Of particular interest have been various articles concerning the use of two-way enteroscopy in large series of patients with obscure gastrointestinal bleeding or with radiological abnormalities. Reports continue to appear describing a high incidence of gastroduodenal or colonic lesions that were missed or misinterpreted during previous upper and lower endoscopies in patients with recurrent obscure bleeding. By contrast, there have been few outcome studies on patients with obscure bleeding, and the conclusions reached are not in full agreement. Other important publications have stressed the value of enteroscopy in selected cases of chronic unexplained diarrhea, for diagnosing small-bowel lesions caused by nonsteroidal anti-inflammatory drugs, and in identifying small-bowel tumors. In addition to numerous reports on intraoperative enteroscopy, the results of initial experience with laparoscopically assisted enteroscopy have also been reported.
免疫系统的某些分子如何影响大疱性类天疱疮
Authors: A. Kamata, Y. Kurihara, T. Funakoshi, H. Takahashi, K. Kuroda, T. Hachiya, M. Amagai, J. Yamagami
Journal: British Journal of Dermatology (2020)

大疱性类天疱疮 (BP) 是一种罕见的皮肤病,主要影响 60 岁以上的人群。患者出现红色斑块和水疱。BP 是一种自身免疫性皮肤病,即抗体不再攻击它们本应攻击的危险微生物,而会识别并附着在正常皮肤的分子上,导致炎性反应。 BP 自身抗体靶向的两种自身抗原(分子)是 BP180 和 BP230,两者都是基底膜带(BMZ,皮肤外层和中层之间的连接)的组成部分。 除了称为 IgG 的自身抗体外,一个 BP 患者子集表明 BMZ 中一种称为 IgE 的不同抗体沉积(存在),但尚未明确 BMZ IgE 与 BP 严重程度之间的关系。 在这项来自日本的研究中,作者分析了 BMZ 中的 IgE 沉积、血清中的 IgE 水平和 BP 患者的疾病严重程度之间的关系。 首先,作者研究了 53 例大疱性类天疱疮 (BP) 患者的皮肤样本,其中 10 例 BMZ 中的 IgE 沉积较强,13 例沉积较弱。接下来,在这 53 例 PB 患者中,作者专注于治疗前接受过测试的 15 名患者。根据使用大疱性类天疱疮疾病面积指数 (PDAI) 评分进行的测量,BMZ IgE 沉积较强的患者相比无 IgE 沉积的患者 BP 更广泛。 在使用称为全身性皮质类固醇的药物治疗后,BMZ IgE 沉积较强或较弱的患者改善时间较长。相比之下,他们的荨麻疹/红斑 BPDAI 评分没有发现显著差异,该评分测量皮肤发红和荨麻疹等症状。 这表明,BMZ IgE 沉积会影响 BP 患者的水疱形成。与之前的研究一致,结果表明,抗 IgE 疗法(如 omalizmab)不仅可有效治愈红斑(发红)和荨麻疹(风团疹),对 BP 中的糜烂和水疱也很有效。 本摘要涉及研究:基底膜带 IgE 沉积与大疱性类天疱疮疾病严重程度和治疗结果相关。
RTHP-01. DOES THE EFFICACY OF SALVAGE RE-IRRADIATION IN RECURRENT MEDULLOBLASTOMA DEPEND UPON RISK-STRATIFICATION, SITE OF RELAPSE, AND MOLECULAR SUBGROUP?
Authors: Tejpal Gupta, Madan Maitre, Rahul Krishnatry, Goda Jayant Sastri, Neelam Shirsat, Sridhar Epari, Girish Chinnaswamy, Vijay Patil, Aliasgar Moiyadi, Rakesh Jalali
Journal: Neuro-Oncology (2018)

PURPOSE: To report outcomes of salvage re-irradiation in the multi-modality management of recurrent medulloblastoma. Medical records of all patients with recurrent medulloblastoma treated with curative-intent re-irradiation at a single institution were analyzed. A total of 24 patients (median age of 14 years) were included. Median time to recurrence was 38 months (range 15–99 months). Of 13 patients with SHH subgroup medulloblastoma, 11 (85%) developed local recurrence while 5 of 7 (71%) group 4 patients developed focal recurrence outside the tumor bed. Neuraxial dissemination was seen in 2 patients each of SHH and group 4, while the lone patient with WNT-pathway experienced leptomeningeal dissemination. Molecular subgrouping was not known in 3 patients. Re-irradiation was focal in 58%, extended-field in 17%, and craniospinal re-irradiation in 25% patients. Median interval from primary course of irradiation was 49 months (range 24–98 months) and median cumulative biologically effective dose (BED) was 117 Gy (range 78–132 Gy). All patients received platinum-based salvage chemotherapy either before or after re-irradiation. At a median follow-up of 16.5 months, the 2-year post-re-irradiation progression-free survival and overall survival was 45% and 61% respectively. Patients with average-risk medulloblastoma at initial diagnosis fared better than high-risk disease, while site of relapse, and molecular subgrouping did not impact upon outcomes after re-irradiation. Two of 16 failures were in-field of re-irradiation indicating excellent local control. One patient developed symptomatic radiation necrosis. Re-irradiation provides excellent local control and encouraging survival outcomes with acceptable toxicity in carefully selected patients with recurrent medulloblastoma.
Acute small-bowel mucosal edema following enalapril use
Authors: F. A. Farraye
Journal: JAMA (1988)

<h3>In Reply.</h3> —Dr Carlen raises important questions that are pertinent to the practitioner and the dilemma of cost containment. It is conceptually easier to reallocate funds for large groups than to deny care to an individual patient. Three observations, however, are germane. First, there is good evidence that American physicians can practice both excellent and cost-effective medicine. Many recent, well-done studies have shown that "routine" tests, such as the admission chest roentgenogram, may be reduced or eliminated without detriment to the patient, and yet with substantial savings. This procedure alone was performed more than 30 million times in 1980, with $1.5 billion in charges to the consumer.<sup>1</sup> Second, as these studies become aggregate and accepted by professional groups, they help modify existing or create new standards of care. The courts not only consider but welcome standards of practice that are supported by professional groups such as the American Medical
The Peach
Authors: Karen (Gregoire) Fahey
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Court Ruling Expected Soon in Alcoholism Case
Authors: Charles Marwick
Journal: JAMA (1988)

IN THE NEAR FUTURE—probably before summer—the US Supreme Court is expected to rule on a case involving two veterans denied extension of educational benefits because of alcoholism. The Veterans Administration, in denying the benefits, maintains that—in these two cases—alcoholism is willful misconduct and consequently the extension should be disallowed. The case has excited widespread interest, since it initially appeared the court was going to rule whether alcoholism is the result of willful misconduct, as the Veterans Administration claims, or is a disease, as physicians have maintained for three decades. In fact, however, the court's decision is more likely to be made on very much narrower grounds, at least in the view of those arguing the case. "Before argument, there was a lot of publicity over the notion that the Supreme Court was finally going to decide on whether alcoholism is a disease or not. Well, the court is just not
Models in medical research. "Muscles are motors"
Authors: J. T. Apter
Journal: JAMA (1966)

In these few words,<sup>1</sup>the eminent 19th-century physicist described the value of models as a research tool in the physical sciences. Mathematical biologists<sup>2</sup>have demonstrated their acceptance of Maxwell's advice by using models for simplifying and reducing biological data to forms easier for "the mind" to "grasp" so that the next logical step in an investigation may be more readily recognized. The simple analogue model "muscle is a motor" is the subject of this essay. The aim is to explain the successful uses of this model for the three types of muscle<sup>3-6</sup>at three levels of structural organization (organ,<sup>3</sup>individual muscles,<sup>4</sup>and constituent molecules<sup>5,6</sup>). In all the examples selected for discussion, the physical concept "motor" was substituted for the physiological concept "muscle." "Muscle is a motor" serves as a model not only because essential features of muscle are matched but because more readily manipulable material
Clinical and Histopathological Analysis of 20-Year Series of Cases Originally Diagnosed as Chorio-Epithelioma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gorleston Holiday Camp for the Physically Handicapped
Authors: I. B. M. Green
Journal: BMJ (1956)

<h3>Abstract</h3> <h3>Introduction</h3> Efficient therapeutic strategies are needed to counter the COVID-19 pandemic, caused by the SARSCoV-2 virus. In a context where specific vaccines are not yet available, the containment of the pandemic would be facilitated with efficient prophylaxis. <h3>Methods</h3> We screened several clinical trials repositories and platforms in search of the prophylactic strategies that are investigated against COVID-19 in late April 2020. <h3>Results</h3> Up to April 27, 2020, we found 68 clinical trials targeting medical workers (n = 43, 63%), patients relatives (n = 16, 24%) or individuals at risk of severe COVID-19 (n = 5, 7%). (Hydroxy)chloroquine was the most frequently evaluated treatment (n = 46, 68%), before BCG vaccine (n = 5, 7%). Sixty-one (90%) clinical trials were randomized with a median of planned inclusions of 600 (IQR 255–1515). <h3>Conclusion</h3> The investigated prophylaxis strategies cover both pre- and post-exposure prophylaxis and study numerous immune enhancers and antivirals, although most research efforts are focused on (hydroxy)chloroquine.
Reactions to Intravenous Iron Dextran
Authors: R. S. Lane, J. M. Scott
Journal: BMJ (1965)

whom had received cephaloridine.We used a Levinthal agar-dilution technique with an inoculum of 0.004 ml. of a 1: 250 dilution of an overnight broth culture (104 organisms).The Table shows that for 27 of the 52 strains the M.I.C. was above the level likely to be obtained with the recommended dose.M.I.C.(pg.Iml.) 40 20 10 5 4 3 21 TotalNo. of strains 6 21 13 1 3 6 1 1 52If this drug is used for the treatment of respiratory infections due to H. influenzae it is possible that it may not always be effective.-We are, etc.,
Relationships between Free Cadmium Ion Activity in Seawater, Cadmium Accumulation and Subcellular Distribution, and Growth in Polychaetes
Authors: Kenneth D. Jenkins, Brenda M. Sanders
Journal: Environmental Health Perspectives (1986)

We have examined the relationships between Cd ion activity {Cd2"}, in seawater, Cd accumulation and subcellular distribution and growth in the polychaete Neanthes arenaceodentata.Organisms were exposed for 3 weeks to a range of {Cd2+} in a Cd-chelate buffer system.Cadmium accumulation and growth were monitored weekly for each exposure group and subcellular Cd distributions were determined at the end of the 3-week period.We found Cd associated with all of the subcellular fractions except the very low molecular weight ligands.Total Cd accumulation was greatest at day 7 and decreased over time in all but the highest {Cd2+} where it remained constant.For each point in time, however, there was a linear relationship between total Cd and {Cd2"} in seawater.Linear relationships were also observed between {Cd2+} and Cd loading in each subcellular ligand pool.Specific growth rates varied with both {Cd2"} and time in a nonlinear manner.
AMERICAN SANITARY ACHIEVEMENTS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ROYAL SOCIETY OF MEDICINE..
Authors: Louis Forman
Journal: British Journal of Dermatology (1957)

Journal Article ROYAL SOCIETY OF MEDICINE.: SECTION OF DERMATOLOGY. Get access Louis Forman Louis Forman Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 6, 1 June 1957, Pages 223–231, https://doi.org/10.1111/j.1365-2133.1957.tb13259.x Published: 01 June 1957
Leptomeningeal dissemination in children with progressive low-grade neuroepithelial tumors
Authors: Juliette Hukin, Joao Siffert, Linda Velasquez, David Zagzag, Jeffrey Allen
Journal: Neuro-Oncology (2002)

Our purpose is to describe the incidence and clinical features of leptomeningeal dissemination (LM) in children with progressive low-grade neuroepithelial tumor (LGN).We have continuously tracked all patients with primary CNS tumors since 1986.Satisfactorily followed data were obtained on 427 of the 588 patients with localized LGN at diagnosis between 1986 and 1998, 177 (42%) of whom developed progressive or recurrent disease.LM was identi ed in 13/177 (7%).The median age at initial diagnosis was 5 years and at LM diagnosis was 8.5 years.The primary tumor sites were diencephalon (6), brainstem (3), cerebellum (2), cerebrum (1), and spinal cord (1).The histologies were pilocytic astrocytoma (4), ganglioglioma (4), brillary astrocytoma (3), mixed glioma (1), and glioneuro broma (1).Management included chemotherapy (2) or radiotherapy (3) or both (7); 1 patient received only radical resections of symptomatic lesions.The 5-year progression-free survival rates for patients with localized versus LM disease at recurrence were 22% (95% condence interval [CI], 13%-25%) versus 15% (95% CI, 0.1%-36%), respectively (P = 0.28).The 5-and 10-year overall survival rates for patients with localized disease versus LM were 87% (95% CI, 82%-92%) and 83% (95% CI, 77%-89%) versus 68% (95% CI, 39%-91%) and 68% (95% CI, 39%-91%), respectively (P = 0.05).The 7% incidence of LM is a low estimate because patients were not routinely staged at recurrence.Tumors arising from the diencephalon appeared to predispose to LM; no other predisposing features were identi ed.We strongly urge that for optimum treatment planning all
As bases anátomo-patológicas da neuriatria e psiquiatria. Volumes I e II
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Corrigendum: Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension
Authors: ShengYu Mu, Tatsuo Shimosawa, Sayoko Ogura, Hong Wang, Yuzaburo Uetake, Fumiko Kawakami-Mori, Takeshi Marumo, Yutaka Yatomi, David S Geller, Hirotoshi Tanaka, Toshiro Fujita
Journal: Nature Medicine (2012)
Book Review The Blood Bank and the Technique and Therapeutics of Transfusions . By Robert A. Kilduffe, A.M., MD., and Michael DeBakey, M.D., M.S. 8°, cloth, 558 pp., with 214 illustrations and 1 color plate. St. Louis: The C. V. Mosby Company, 1942. $7.50.
Journal: New England Journal of Medicine (1943)
Index to Advertisers
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic variants of <i>hENT-1</i> to predict efficacy of TAS-102 in patients with refractory metastatic colorectal cancer.
Authors: Wu Zhang, Mitsukuni Suenaga, Marta Schirripa, Shu Cao, Dongyun Yang, Martin D. Berger, Jordan David West, Yan Ning, Takeru Wakatsuki, Tetsuo Mashima, Satoshi Okazaki, Yuji Miyamoto, Diana L. Hanna, Federica Marmorino, Lisa Salvatore, Roberto Moretto, Beatrice Borelli, Afsaneh Barzi, Fotios Loupakis, Heinz-Josef Lenz
Journal: Journal of Clinical Oncology (2016)

3580 Background: Trifluridine (FTD) is an active cytotoxic component of TAS-102, and incorporation of tri-phosphorylated FTD into DNA confers its anti-tumor effect. Recent reports suggest that decreased expression of human equilibrative nucleoside transporter (hENT) and thymidine kinase 1 (TK-1) results in decreased nuclear intake of FTD. We tested whether gene polymorphisms involved in FTD metabolism are associated with outcomes in patients with refractory metastatic colorectal cancer (mCRC) treated with TAS-102. Methods: We analyzed genomic DNA extracted from 104 blood samples of two different cohorts: an evaluation set of 52 patients receiving TAS-102 (median age 61 years, male 44%, median follow-up time, 6.4 months), and a control group of 52 patients receiving regorafenib without history of TAS-102 treatment (median age 64 years, male 44%, all patients deceased). Single nucleotide polymorphisms (SNPs) of genes in FTD metabolism (TK-1, hENT-1) were analyzed by PCR-based direct sequencing. The candidate SNPs were selected by their frequency and potential function. Associations between selectedSNPs and PFS and OS were evaluated by Kaplan-Meier and log-rank tests in the overall population. Cox proportional hazard regression model was used in multivariate analyses. Results: In univariate analysis, median PFS for patients with any hENT-1 rs760370 G allele was 3.5 vs. 2.1 months for those carrying the A/A genotype (HR 0.44, 95%CI: 0.23-0.83, p = 0.004). Median OS was 8.7 and 5.3 months in the two groups, respectively (HR 0.27, 95%CI: 0.10-0.70, p = 0.003). Among patients with any hENT-1 rs9394992 T allele, median PFS was 3.4 vs. 1.9 months for those with the C/C variant (HR 0.48, 95%CI: 0.25-0.91, p = 0.011). Median OS was 8.7 vs. 4.4 months (HR 0.21, 95%CI: 0.08-0.51, p < 0.001) in the two groups, respectively. In multivariate analysis, hENT-1 rs760370 and hENT-1 rs9394992 genotypes remained significantly associated with PFS and OS. No significant differences were observed in the control group. Conclusions: hENT-1 germline polymorphisms may serve as predictive and prognostic markers in mCRC patients treated with TAS-102.
Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2012: Table 1
Authors: Daniel E Furst, Edward Clark Keystone, Alexander K So, Jürgen Braun, Ferry C Breedveld, Gerd R Burmester, Fabrizio De Benedetti, Thomas Dörner, Paul Emery, Roy Fleischmann, Allan Gibofsky, J R Kalden, Arthur Kavanaugh, Bruce Kirkham, Philip Mease, A Rubbert-Roth, Joachim Sieper, Nora G Singer, Josef S Smolen, Piet L C M Van Riel, Michael H Weisman, Kevin L Winthrop
Journal: Annals of the Rheumatic Diseases (2013)
Pathogenic mechanisms in inflammatory bowel disease
Authors: T Mayall, T Peters
Journal: Gut (1992)

In active inflammatory bowel disease there is epithelial cell damage, and consequently increased permeability to luminal contents.Colonocyte metabolism relies on mitochondrial oxidative phosphorylation with butyrate as carbon-source; butyrate usage is impaired in active ulcerative colitis (UC).To investigate whether colonocyte damage results in impaired milochondrial biogenesis, we have studied mitochondrial function in inflammatory bowel disease.the "chronic" inflammatory group and in controls are best explained by a dissociation of the heterodimere antibody 27E10.S2;4