tbuckley/cabot-search huggingface dataset:
Voluntary health agencies and government. A promising partnership
Authors: P. M. Ellwood
Journal: JAMA (1966)

The expanding role of government in the health field confronts voluntary health agencies, not with obsolescence, but with new challenges. Only if these agencies lose their verve and flexibility will their future be in jeopardy. Changes in their relationship to government obviously are taking place. In 1946, federal appropriations for health research were under a million dollars. In 1955, at $60 million, they had already surpassed the sums raised by voluntary health agencies. Since then, the funds channeled into research by voluntary agencies have continued to grow slowly. Meanwhile, government money for health research has increased explosively—to $600 million in the fiscal year 1964 for the National Institutes of Health alone and to a fiscal-year 1966 total which is expected to exceed a billion dollars. Voluntary health agencies used to provide much of the medical care and other welfare services for the less fortunate. Today the scope of the government
Abstract 2269: Exogenous Sulfide Limits Inflammation in Response to Myocardial Ischemia - Reperfusion Injury
Authors: Neel R Sodha, Richard T Clements, Jun Feng, Yuhong Liu, Cesario Bianchi, Csaba Szabo, Gregory L Stahl, Frank W Sellke
Journal: Circulation (2007)

Introduction : Hydrogen sulfide (H 2 S) is produced endogenously in response to myocardial ischemia and thought to be cardioprotective. The mechanism underlying this protection has yet to be fully elucidated, but may be related to the ability of sulfide to limit inflammation. This study investigates the cardioprotection provided by exogenous H 2 S, generated as sodium sulfide, and its potential anti-inflammatory mechanism of action. Methods : The mid-LAD coronary artery in 12 Yorkshire swine was acutely occluded for 60 min, followed by reperfusion for 120 min. Controls (6) received placebo, and treatment animals (6) received sulfide 10 min prior to reperfusion. Hemodynamic, global, and regional functional measurements were obtained. Evans blue and TTC staining identified the area at risk (AAR) and infarction. Coronary microvascular reactivity was assessed. Tissue was assayed for myeloperoxidase (MPO) activity and inflammatory cytokines. Results : Pre-I/R hemodynamics were similar between groups, whereas post-I/R mean arterial pressure (mmHg) was reduced by 28.7±5.0 in controls vs. 6.7±6.2 in treatment animals (p&lt;0.05). +LV dP/dt (mmHg/sec) was reduced by 1325±455 in controls vs. 416±207 in treatment animals (p&lt;0.05). Segmental shortening in the AAR was better in treatment animals. Infarct size (% of AAR) in controls was 41.0±7.8% vs. 21.2±2.5% in the treated group (p&lt;0.05). Tissue levels of IL-6, IL-8, and TNFα (see Table ) and MPO activity decreased in the treatment group (0.0025±0.003 vs. control 0.0397±0.016 units/mg protein (p&lt;0.05)). Treated animals demonstrated improved microvascular reactivity. Conclusions : Sodium sulfide provides significant protection in response to I/R injury, improving myocardial function, reducing infarct size, and improving coronary microvascular reactivity, potentially through its anti-inflammatory properties. Exogenous sulfide may have therapeutic utility in clinical settings in which I/R injury is encountered. Myocardial Levels of Inflammatory Cytokines
AUTONOMIC NEUROPATHY AND VISCERAL FUNCTION
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The caffeine breath test does not identify patients susceptible to tacrine hepatotoxicity
Authors: R Fontana
Journal: Hepatology (1996)

Therapy with tacrine, a promising new treatment for Alzheimer's disease, must be discontinued in up to 15% of patients because of hepatocellular toxicity. Recent studies using human liver microsomes have suggested that a single liver enzyme, cytochrome P450 1A2 (CYP1A2), catalyzes the major route of metabolism and elimination of tacrine, and also catalyzes the pathway(s) involved in the generation of reactive metabolites capable of covalent protein binding and cytotoxicity. Because CYP1A2 activity has been shown to vary up to 60- fold among patients, we proposed that a convenient measure of CYP1A2 activity, the [13C 3-methyl] caffeine breath test (CBT), might be clinically useful in identifying patients most susceptible to tacrine liver toxicity. To test this hypothesis, we administered the CBT to 37 patients with Alzheimer's disease before they began treatment with tacrine. Twenty patients received 2 mg/kg of [(13)C 3-methyl] caffeine. The remaining 17 patients received the commercially available CBT kit, which employs a constant 200-mg dose. The activities of two other major drug-metabolizing enzymes (cytochrome P450 3A4 and 2D6 [CYP3A4 and CYP2D6]) were also measured in these 17 patients. We found that the results obtained from the CBT protocol did not predict the peak serum alanine transaminase (ALT) observed in the patients. The measured CYP3A4 and CYP2D6 activities also failed to predict the susceptible patients. However, the result of the standardized-dose CBT correlated well with the logarithm of the steady-state plasma tacrine level obtained in 10 patients (R2 = .69, P = .003). We conclude that the CBT will not be clinically useful in determining the subset of patients most susceptible to tacrine hepatotoxicity. However, the correlation we observed between CBT results and tacrine blood levels is the first evidence supporting a critical role for CYP1A2 activity in the disposition of the drug in vivo.
Endogenous estrogen levels and calcium intakes in postmenopausal women. Relationships with cortical bone measures
Authors: J. A. Cauley
Journal: JAMA (1988)

To examine the interactions between hormone levels and calcium with cortical bone, we have attempted to combine risk factors for the development of peak skeletal mass with factors that may be related to the maintenance of bone integrity after menopause. A total of 174 postmenopausal women participated in our study. There was little relationship found between androgen hormones and radial bone density. Estrone levels were independently related to radial bone density. Examination of the relationship of calcium intake to bone revealed a protective effect solely in women who reported high "lifetime" calcium intakes. Taking calcium and estrone together revealed an additive relationship between the two factors, in that women with high estrone and high calcium levels had significantly greater bone density than women with less calcium and/or estrone. The results suggest that a lifetime of adequate calcium intake coupled with adequate levels of serum estrogens could maximize bone density after menopause. (<i>JAMA</i>1988;260:3150-3155)
Lehrbuch der Differentialdiagnose innerer Krankheiten
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SIDETRACKED BLOOD CORPUSCLES
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatric Surgery
Authors: William B. Kiesewetter
Journal: JAMA (1969)

The third edition of Swenson's textbook should meet with enthusiastic acceptance by the surgical community. Because of its multiple authorship, detailed coverage in certain subspecialty areas is more adequate than in the two previous editions. However, in this effort to be complete, I think that the senior editor has allowed for rather skimpy handling of two important sections, namely, cardiovascular surgery and orthopedics. They should either have been expanded and dealt with adequately, as are urology and neurosurgery, or they should have been eliminated, inasmuch as they are well covered by other standard textbooks in their specialty fields. Another hazard of a multiple-authored text is quite apparent: the chapters written by Dr. Swenson himself, out of his vast experience, are much superior to those of more-junior authors who have had far less exposure to the disease entities about which they write. A fair variation in the style of presenting material
Diffuse proliferative lupus glomerulonephritis. Recovery from prolonged renal failure
Authors: W. S. Moore
Journal: JAMA (1980)

A patient with systemic lupus erythematosus, diffuse proliferative lupus glomerulonephritis, and deteriorating renal function was treated with immunosuppression. During the subsequent eight weeks of hemodialysis and immunosuppression, substantial recovery of renal function occurred, allowing for cessation of dialysis. In the following year, the endogenous creatinine clearance increased to 30 mL/min. A therapeutic trial of prednisone is indicated for patients with abrupt, severe deterioration in renal function in association with clinical, histological, or serological evidence of activity of lupus nephritis in the absence of other causes of renal failure. (<i>JAMA</i>244:63-65, 1980)
THE ATTEMPTED MURDER OF THE PRESIDENT.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methylpentynol
Authors: V. B. Young
Journal: BMJ (1954)

<b>Background:</b> Previous data have shown an association between DNA sequence variants in the <i>IRF6</i> gene and an increased risk of non-syndromic cleft lip with or without cleft palate (CL/P) in some populations. <b>Objective:</b> To investigate Thai CL/P patients and relative for a 820G→A polymorphism. <b>Subjects:</b> 192 CL/P Thai patients, 177 of their mothers, 73 of their fathers, and 278 controls. <b>Results:</b> There were significant differences in the frequency distributions of both genotypes (p = 0.02) and alleles (p = 0.04) among probands as compared with the control group. The odds ratio calculated for the patients having the GG genotype compared with the other two genotypes (GA and AA) was 1.67 (95% confidence interval, 1.13 to 2.47). This pattern is consistent with a recessive effect of the G allele. No association between any of the parents’ genotypes and CL/P was found. The <i>IRF6</i> 820G→A was responsible for 16.7% of the genetic contribution to CL/P. <b>Conclusions:</b> The findings confirm that <i>IRF6</i> 820G→A is associated with CL/P.
Compensation to Medical Witnesses
Journal: BMJ (1892)

T HE power to compel testimony is inherent in every court, for without it justice could constantly be thwarted.Generally all persons may be compelled to give evidence that is relevant to the matter in controversy.If, therefore, a person who has been duly summoned as a witness at a particular trial absents himself therefrom, without just cause, or attending, refuses to give evidence or to answer questions when directed so to do by the court, he is liable to punishment for contempt."But there are limitations upon the general rule, some based upon principles of legal policy and some upon statutory enactment.In regard to some of these the law is well settled, but in regard to others there is still considerable conflict in judicial opinion.The question, for example, of whether or not the physician is bound, in obedience to process and for the compensation provided by law for ordinary witnesses, to attend at a trial and give evidence, is one upon which, in some of its phases, the courts that have reviewed the matter are not in entire harmony.All agree that the physician, like the ordinary witness, is bound to obey the command of a subpoena to the extent of reporting in court, and further that he must give evidence as to competent facts connected with the controversy that are within his own knowledge.As to such facts he testifies as an ordinary witness.But when he is summoned for the purpose of securing his opinion as an expert upon a given state of facts, as an aid to the court and jury, may he properly refuse to furnish that opinion in the absence of a provision for adequate professional compensation?Different answers to this question have been made by different courts.In some cases the question has assumed this form: Can the medical expert be compelled, for the ordinary witness fees, to attend a trial, listen to the evidence adduced therein, and give his opinion in answer to hypothet-I Best on Evidence (9th Ed.).§ i25.
Mission Impossible?
Journal: JAMA (1970)

In 1962, the University of Wisconsin established the Interdisciplinary Studies Committee on the Future of Man.<sup>1</sup>As its name implies, the Committee has rightfully shared with other elements of our society a growing conviction that the survival of civilization is not something to be taken for granted. Early in 1967, the Committee had posed to it four questions by the Board of Regents relating to the purposes of higher education, the goals for the university as an entity, the goals for each segment of the university, and the extent to which students and student organizations should be involved in university government. In 1969, the Committee responded to the first question as follows: In answer to the Regents' question: "What are the purposes of higher education?" this Committee responded that: The primary purpose of the University Is to provide an environment In which faculty and students Can discover, examine critically, Preserve,
Immunofluorescent and serological findings in no patients with suspected bullous skin disorders
Authors: W.G. Reeves, B.R. Allen, M. Crone, D.W. Marriott, E.D.A. Mitchell, T.B. Wallington
Journal: British Journal of Dermatology (1978)

Journal Article Immunofluorescent and serological findings in no patients with suspected bullous skin disorders Get access W.G. Reeves, W.G. Reeves Departments of Immunology and Dermatology, University Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar B.R. Allen, B.R. Allen Departments of Immunology and Dermatology, University Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar M. Crone, M. Crone Departments of Immunology and Dermatology, University Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar D.W. Marriott, D.W. Marriott Departments of Immunology and Dermatology, University Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar E.D.A. Mitchell, E.D.A. Mitchell Departments of Immunology and Dermatology, University Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar T.B. Wallington T.B. Wallington Departments of Immunology and Dermatology, University Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue s16, 1 December 1978, Pages 15–16, https://doi.org/10.1111/j.1365-2133.1978.tb15209.x Published: 01 December 1978
Contents
Authors: Jithin Yohannan, Michael Cheng, Joseph Da, Sagar Chapagain, Ayodeji Sotimehin, Luke Ba, Aleksandra Bonham, Michael Scm, Pradeep Ramulu, Balwantray Chauhan, Jayme Vianna, Glen Sharpe, Shaban Demirel, Christopher Girkin, Christian Mardin, Alexander Scheuerle, Claude Burgoyne, David Liao, Federico Grossi, Delphine El Mehdi, Monica Gerber, David Brown, Jeffrey Heier, Charles Wykoff, Lawrence Singerman, Prema Abraham, Felix Grassmann, Peter Nuernberg, Bernhard Weber, Pascal Deschatelets, Robert Kim, Carol Chung, Ramiro Ribeiro, Mohamed Hamdani, Philip Rosenfeld, David Boyer, Jason Slakter, Cedric Francois, Wai Wong, Mark Gillies, Alex Hunyor, Jennifer Arnold, Robyn Guymer, Sebastian Wolf, Francois Pecheur, Marion Munk, Ian Mcallister, Nadia Waheed, John Kitchens, Sunil Patel, Robert Vitti, Lorah Perlee, Karen Chu, Sergio Leal, Friedrich Asmus, Vladimir Son, Thomas Schmelter, Devon Cohen, M Tariq Bhatti, Jose Pulido, Vanda Lennon, Divyanshu Dubey, Eoin Flanagan, Sean Pittock, Christopher Klein, John Chen
Journal: Ophthalmology (2020)
Corrections
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACUTE PARALYTIC DILATATION OF STOMACH.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal