tbuckley/cabot-search huggingface dataset:
A HUMAN INCUBATOR.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Klinicheskaia Meditsina, Moscow
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Weaning from mechanical ventilation
Authors: S. A. Sahn
Journal: JAMA (1976)

PATIENTS who require mechanical ventilation will either be promptly weaned from the ventilator and the endotracheal tube or require more prolonged ventilatory assistance by means of a tracheostomy. Those who recover ventilatory capacity and effective pulmonary oxygen transport rapidly are better able to participate in procedures designed to promote their recovery and rehabilitation and therefore have the best prognosis. In these patients, the potential hazards of prolonged endotracheal intubation are usually avoided by early weaning.<sup>1</sup>Thus, it is imperative that the respiratory care physician constantly evaluate the need for continued ventilatory support and discontinue it and remove the artificial airway as soon as feasible. The time to consider weaning a patient from the ventilator is immediately after the respiratory emergency has been stabilized. Therefore, the original indications for ventilatory assistance, the overall clinical condition, and the physiologic resources of the patient must be continuously evaluated. <h3>PROPOSED CRITERIA FOR WEANING</h3>
Incorrect Author Name in the Byline
Journal: JAMA Psychiatry (2016)

Babak Hooshmand, MD, PhD, MPH; Francesca Mangialasche, MD, PhD; Grégoria Kalpouzos, PhD; Alina Solomon, MD, PhD; Ingemar Kåreholt, MD, PhD; A David Smith, PhD; Helga Refsum, MD, PhD; Rui Wang, PhD; Marc Mühlmann, MD; Birgit Ertl-Wagner, MD; Erika Jonsson Laukka, PhD; Lars Bäckman, PhD; Laura Fratiglioni, MD, PhD; Miia Kivipelto, MD, PhD
Periurethral or perineal bacteria in urinary tract infections?
Authors: T. A. Stamey
Journal: JAMA (1981)

<h3>To the Editor.—</h3> In response to the article by Kunin et al, "Periurethral Bacterial Flora in Women: Prolonged Intermittent Colonization With<i>Escherichia coli</i>" (1980;243:134), the authors are unable to confirm our observations that colonization of the vaginal introitus with Enterobacteriaceae is greater in women susceptible to urinary tract infections (UTIs), in between episodes of bacteriuria, than it is in control, healthy women who appear resistant to UTIs. Our data are based on findings from introital swab cultures taken at the level of the hymenal ring obtained by a trained nurse. Kunin and associates relied on self-collected, dipstick cultures of the midstream voided urine. Self-collected, voided urine specimens from women include not only periurethral bacteria, but also those bacteria on the labia minora and majora. They may even include organisms from the perineal bridge separating the vagina from the rectum. Such contaminating bacteria should be labeled as perineal, not periurethral. It
ESSENTIAL HYPOTENSION
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of serum and tissue biomarker analysis embedded in a phase II clinical trial of cytarabine in castration-refractory prostate cancer to investigate prostate cancer biology.
Authors: J. Groskopf, S. Niraula, U. Emmeneger, L. Adams, I. Tannock, S. S. Sridhar, J. J. Knox, J. R. Day, J. Manthe, A. M. Joshua
Journal: Journal of Clinical Oncology (2011)

e15022 Background: Other than the androgen receptor, the TMPRSS2-ERG genomic aberrations in prostate cancer provide the first recent opportunity to target therapy in castration refractory prostate cancer (CRPC). We initiated a phase 2 clinical trial of cytarabine in docetaxel refractory CRPC on the basis of microarray, in vitro and case report evidence that cytarabine may be particularly effective in men harbouring abnormalities of the ERG oncogenes. Embedded in this clinical trial was the first use of blood mRNA levels of prostate cancer related genes as biomarkers of response and prognosis. Methods: Patients with docetaxel refractory progressive CRPC received intravenous cytarabine at doses between 1g/m2- 0.25 g/m2 q3 weekly. Responses were defined according to PCWG2C. 10 patients were enrolled between June 2007 and January 2010. TMPRSS2:ERG, PSA and PCA3 mRNA copies in whole blood collected with PAXgene tubes at the beginning of each cycle and at trial termination were quantified using transcription-mediated amplification assays. The prototype TMPRSS2:ERG assay detects the gene fusion isoform TMPRSS2 exon1 to ERG exon4. Results: No patients demonstrated a serum PSA response (PCWG2C). The average number of cycles administered was 2.6. Significant toxicities included grade 3-4 thrombocytopenia (2) and grade 3-4 neutropenia (3). These toxicities necessitated several dose reductions in the protocol, however most patients were removed from trial for serum PSA progression alone. PCA3 and PSA mRNAs were detectable in 8/10 and 9/10 cases, respectively; there was no correlation between serum PSA and PCA3 or PSA mRNA copy levels in blood. Testing for TMPRSS2:ERG in blood was able to predict the presence or absence of the TMPRSS2-ERG rearrangement in 9/10 cases when compared to 3 colour FISH carried out on baseline biopsies/ prostatectomies (2/10 positive for Exon 4:Exon 1 deletion). Conclusions: Cytarabine administation is ineffective in docetaxel refractory CRPC. Blood mRNA levels of prostate cancer genes reveal novel aspects of prostate cancer biology and have implications for the understanding of circulating tumour cells.
Clinical-radiomics analysis for preoperative prediction of objective response to transarterial chemoembolization in hepatocellular carcinoma
Authors: Mingyu Chen, Jiasheng Cao, Jiahao Hu, Win Topatana, Shijie Li, Sarun Juengpanich, Jian Lin, Jennifer Wu, Xiujun Cai
Journal: Journal of Hepatology (2020)
Evaluation of a new endoscopic index to predict first bleeding from the upper gastrointestinal tract in patients with cirrhosis
Authors: M Zoli, C Merkel, D Magalotti, G Marchesini, A Gatta, E Pisi
Journal: Hepatology (1996)

The aim of this study was to prospectively evaluate the usefulness of the Italian Liver Cirrhosis Project (ILCP) classification of esophageal varices, together with the gastric features of portal hypertension, in predicting the first upper gastrointestinal bleeding in cirrhosis. The efficiency of these endoscopic parameters in predicting bleeding was also compared with the efficiency of the North Italian Endoscopic Club (NIEC) index. Three hundred forty–four cirrhotic patients with esophageal varices but without any previous bleeding were enrolled in the study. The following endoscopic parameters of esophageal varices were recorded: location, size, occupancy, blue tone, and red color signs. Gastric varices were graded as absent or present, while congestive gastropathy was considered as absent, mild to moderate, or severe. All patients were followed until the first upper gastrointestinal bleeding and/or death, or for at least 24 months. No patient received any treatment to prevent bleeding. Sixty–five patients bled from the upper gastrointestinal tract during the study. Univariate analysis showed that all endoscopic parameters were predictors of bleeding. According to multivariate analysis (Cox's model), size, gastric varices and congestive gastropathy were the only independent predictors of bleeding, and the following prognostic index (PI) was developed: PI = (size × 0.0395) + (congestive gastropathy × 0.878) + (gastric varices × 0.705). This index, which was validated using a split–sample technique, and which appears to be superior to the NIEC index in predicting bleeding, may be useful in decision making for primary prophylaxis.
The American foreign graduate
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic Ascaridiasis
Authors: M. Van Severen, B. Lengele, J. Dureuil, M. Shapira, Ch. Dive
Journal: Endoscopy (1987)

Adult Ascaris, which are usually found in the intestine, can enter the ampulla of Vater if the sphincter of Oddi is not efficient. This situation seems common in children; in adults it occurs after endoscopic or surgical sphincterotomy.
Medical News
Journal: JAMA (1905)

<h3>ALABAMA.</h3><h3>Physician Fined.</h3> —Dr. M. D. Welborn, Ezell Station, near Pratt City, who was arrested several days ago on the charge of selling cocain, was fined $100 and costs October 3. <h3>Medical Colleges Opened.</h3> —The Birmingham Medical College opened for its annual session October 3. Addresses were made by Drs. Russell M. W. Cunningham, Ensley; Dr. Edward H. Sholl, Dr. John C. Le Grande and others.—The medical department of the University of Alabama, Mobile, opened October 5. <h3>Personal.</h3> —Dr. William T. Berry has been elected professor of orthopedic surgery in the Birmingham Medical College, a chair established this year.—Dr. Shirley Bragg, Montgomery, has been made president of the board of convict inspectors, and Dr. Nathaniel G. Clark, Ensley, physician inspector of convicts of the state. <h3>Alumni Organized.</h3> —The Alumni Association of Birmingham Medical College met for organization October 3 and elected the following officers: President, Dr. Joseph H. Edwards, Wylam;
National institutes of health consensus development conference: Management of hepatitis C: 2002
Authors: Leonard B. Seeff, Jay H. Hoofnagle
Journal: Hepatology (2002)

en-I titled "Management of Hepatitis C." The proceedings of that conference and the final Consensus Statement were published in Hepatologl and have had a major influence on clinical practice and approach to this disease.That conference was prompted by the uncertainty and confusion that surrounded the issues of the natural history, diagnosis, management, and particularly treatment of hepatitis C. At the time, the only available treatment for hepatitis C was monotherapy with interferon alfa.Overall, response rates to 24and 48-week courses of interferon were poor, adverse reactions were common, and costs were high.The Consensus Panel formulated recommendations based on the best available medical evidence and concluded that treatment should be offered to adult patients, ages 18 to 60 years, with chronic hepatitis C and the presence of hepatitis C virus (HCV) RNA in serum, persistently elevated alanine aminotransferase (ALT) activities, and a liver biopsy showing either portal or bridging fibrosis and at least moderate degrees of inflammation and necrosis.Despite the paucity of information, the Panel also recommended treatment of persons with acute hepatitis C and of persons with HCV-human immunodeficiency virus (HIV) coinfection provided they had a good clinical and functional status.The Panel further concluded that indications for therapy were less obvious for persons with histologically mild disease, for persons with compensated cirrhosis, and for children and the elderly.Finally, the Panel recommended that treatment should not be offered to patients with normal ALT values, patients with decompensated cirrhosis, and persons who drank "significant amounts of alcohol or who are actively using illicit drugs" until their habit had been discontinued for at least 6 months.
The 'barely veiled warning'
Authors: M. F. Loudon
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Societies.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lehrbuch der Nervenkrankheiten für Aerzte und Studierende.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P08.71 Treatment outcome of patients with recurrent glioblastoma multiforme: a retrospective multicenter analysis
Authors: M. E. van Linde, C. G. Brahm, P. C. de Witt Hamer, J. C. Reijneveld, A. M. Bruynzeel, M. Wagemakers, H. L. van der Weide, R. H. Enting, H. M. W. Verheul, A. M. E. Walenkamp
Journal: Neuro-Oncology (2016)
Impact of pre-treatment neutrophil-lymphocyte ratio on outcomes in men receiving radical external beam radiotherapy for localised prostate cancer.
Authors: Ciara Lyons, Sagar Kanabar, Darren M. Mitchell, Jacqueline A. Harney, Jonathan McAleese, Lin Shum, David P. Stewart, Joe M. O'Sullivan, Suneil Jain
Journal: Journal of Clinical Oncology (2016)

e16604 Background: There is a shortage of novel biomarkers in clinical use for the diagnosis and management of prostate cancer (PC). The neutrophil-lymphocyte ratio (NLR) is derived from a standard full blood count, which is readily available and relatively inexpensive. An elevated NLR has been shown to be a poor prognostic biomarker in many advanced solid cancers, including PC; however, data on NLR in non-metastatic PC have been inconsistent. The objective of this study was to evaluate baseline NLR as an independent predictor of outcome. Methods: Clinical data from 473 consecutive PC patients treated with radical EBRT between 2005 and 2009 in Northern Ireland were reviewed. Patients were identified using the ARIA oncology information system. Detailed clinical information, including comorbidities and risk grouping, was obtained via an electronic medical record, a radiological results system and a pathological results database. Outcomes of interest included biochemical progression-free survival (bPFS), prostate cancer-specific survival (PCSS) and overall survival (OS). The cohort was divided into three paired groups (by biochemical failure (BF) /non-BF, by PCSS and by OS) and the NLR calculated for each group. A two-tailed Mann-Whitney test was used to compare median NLR within each group. Results: Complete data for 463 patients were available. 10 patients were excluded as insufficient baseline data were available. At a median follow-up of 92 months (range 22 – 139), 89 men (19%) had manifested BF, 11 men (2%) had died of PC, and 80 men (17%) had died of all causes. Actuarial 5-year bPFS was 90%, PCSS was 98% and OS was 90%. Conclusions: In this cohort with medium- to long-term follow-up, NLR was not predictive for bPFS, PCSS or OS. Evaluation of serial NLR values (pre-ADT / pre- and post-RT) and multivariate analysis of this cohort is planned. Additional prognostic biomarkers are required in prostate cancer. Median / Mean NLR Range p-value BF BF 2.43 / 2.61 1.06 – 6.04 0.779 Non-BF 2.42 / 2.65 0.34 – 8.83 PCSS Death from PC 2.20 / 2.26 1.08 – 3.96 Insufficient events for further analysis Alive 2.42 / 2.63 0.34 – 8.83 OS Death (all causes) 2.44 / 2.73 0.93 – 8.25 0.689 Alive 2.42 / 2.63 0.34 – 8.83
Dermatology
Authors: J. Graham Smith
Journal: JAMA (1979)

Investigations during the past year may aid in both the understanding and treatment of two major skin problems: psoriasis and acne. <h3>Psoriasis and Dialysis</h3> The serendipitous observation<sup>1</sup>that psoriasis cleared in patients treated with dialysis for end-stage renal disease has only recently begun to receive attention. Patients with psoriasis, with and without impaired renal function, who were treated with either hemodialysis or peritoneal dialysis have also had improvement according to other, independent studies from Missouri,<sup>2</sup>Ohio,<sup>3</sup>Minnesota,<sup>4</sup>and India.<sup>5</sup>Although not all patients with psoriasis respond to dialysis, when they do, a clinical response is usually noted within four weeks of the beginning of treatment; often, complete remission is observed at eight weeks. Some of these remissions have lasted from six to 18 months.<sup>6</sup>However, pustular psoriasis does not appear to respond to dialysis.<sup>2</sup>Preliminary information from two patients suggests that dialysis may
Virologic causes for DAA treatment failure of chronic hepatitis C
Authors: Chun-Ming Hong, Chun-Jen Liu, You-Yu Lin, Shiou-Hwei Yeh, Hung-Chih Yang, Jia-Horng Kao, Ja-Der Liang, Chien-Hung Chen, Chieh-Chang Chen, Feng-Chiao Tsai, Guan-Tarn Huang, Shih-Jer Hsu, Pei-Ming Yang, Jin-Chuan Sheu, Chien-Ching Hung, Hsin-Yun Sun, Cha-Ze Lee, Sih-Han Liao, Yi-Hsiang Huang, Sheng-Shun Yang, Ming-Lung Yu, Pei-Jer Chen
Journal: Journal of Hepatology (2020)