tbuckley/cabot-search huggingface dataset:
Microarray-Based Expression Profiling of Normal and Malignant Immune Cells
Authors: R. D. Medh
Journal: Endocrine Reviews (2002)

Recent advances in gene microarray technology have facilitated global analyses of gene expression profiles in normal and malignant immune cells.Great strides have been made in our understanding of molecular differences among various types of immune cells, the process of T and B cell activation, and the genomic changes that convert normal cells to malignant ones.Genomic analysis has become a crucial aspect of cancer classification, diagnosis, therapy, and prognosis.This technology has the potential to reveal the comprehensive transcriptional alterations that dictate fundamental biological processes such as signal transduction in response to specific stimuli, cell growth, differentiation, and apoptosis.While reaping the benefits of genomic analyses, it is important to realize its limitations with respect to accuracy of interpretation, reproducibility, and signal detection.It is crucial to optimize signals for individual probe-target pairs and to develop a uniform set of criteria for data analyses.The development of a public-access database of results from individual laboratories will pave the way for identifying discrepancies and advancing scientific breakthroughs.
217TiP Dose-finding phase Ib study of FOLFOXIRI plus ramucirumab as first-line therapy for patients with metastatic colorectal cancer
Authors: K. Yamazaki, Y. Kito, T. Esaki, H. Satake, H. Taniguchi, T. Tsuda, T. Denda, T. Moriwaki, K. Mori
Journal: Annals of Oncology (2016)
Studies in chronic allergic bronchopulmonary aspergillosis. 2. Radiological findings.
Authors: J L Malo, J Pepys, G Simon
Journal: Thorax (1977)

The characteristics and the incidence of changes in plain chest radiographs were analysed in detail in 50 asthmatic patients with chronic allergic bronchopulmonary aspergillosis in whom the diagnosis had been made from 2 to 25 years previously (mean duration 10-9 years). One thousand two hundred and forty-two chest radiographs, an average of about two per year per patient, were reviewed. Two hundred and sixty-seven acute episodes of transient shadows (a mean of 5-3 per patient), mostly homogeneous consolidations and band-like shadows, were recorded throughout the period of follow-up. Features of overinflation were present in 21 patients in the first radiograph and in 17 in the last, the decrease being attributed to the effects of permanent lung damage due to the allergic aspergillosis. Permanent changes, such as tubular and ring shadows, loss of vascular shadows, and lobar shrinkage were recorded in 41 patients at the start and in 49 at the end of the follow-up. The tubular shadows were found in 28 patients in the first radiograph and in 45 in the last, whereas ring shadows were seen in 18 and 30 patients respectively. Half of the episodes of consolidation and atelectasis left permanent changes, mainly ring shadows, as seen in the last radiograph. Of the band-like shadows, 32% were found to be followed by the subsequent appearance of tubular shadows. Statistically significant correlations were found between the duration of aspergillosis, the number of transient shadows throughout the period of follow-up, the extent of the permanent shadows, and the reduction of gas transfer factor at the time of the final follow-up.
Imipenem overprescribing
Authors: A. T. Taylor
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study
Authors: D. A. Regier
Journal: JAMA (1990)

The prevalence of comorbid alcohol, other drug, and mental disorders in the US total community and institutional population was determined from 20 291 persons interviewed in the National Institute of Mental Health Epidemiologic Catchment Area Program. Estimated US population lifetime prevalence rates were 22.5% for any non—substance abuse mental disorder, 13.5% for alcohol dependence-abuse, and 6.1% for other drug dependence-abuse. Among those with a mental disorder, the odds ratio of having some addictive disorder was 2.7, with a lifetime prevalence of about 29% (including an overlapping 22% with an alcohol and 15% with another drug disorder). For those with either an alcohol or other drug disorder, the odds of having the other addictive disorder were seven times greater than in the rest of the population. Among those with an alcohol disorder, 37% had a comorbid mental disorder. The highest mental-addictive disorder comorbidity rate was found for those with drug (other than alcohol) disorders, among whom more than half (53%) were found to have a mental disorder with an odds ratio of 4.5. Individuals treated in specialty mental health and addictive disorder clinical settings have significantly higher odds of having comorbid disorders. Among the institutional settings, comorbidity of addictive and severe mental disorders was highest in the prison population, most notably with antisocial personality, schizophrenia, and bipolar disorders. (<i>JAMA</i>. 1990;264:2511-2518)
Rupture of the renal artery after percutaneous transluminal angioplasty
Authors: Lawrence M. Crapo
Journal: JAMA (1987)

<h3>In Reply.—</h3> Hypomagnesemia can occur in diabetic ketoacidosis and has been associated with a decrease in respiratory muscle power, as pointed out by Drs Ryzen and Rude. In our patient, the serum magnesium levels were 2.2 mg/dL (0.9 mmol/L) at the time of the respiratory arrest, 3.9 mg/dL (1.6 mmol/L) 12 hours after arrest, and 2.4 mg/dL (1.0 mmol/L) three days after arrest. These levels are all in or slightly above the normal range for our laboratory (1.7 to 2.80 mg/dL [0.7 to 1.15 mmol/L]). Thus, hypomagnesemia was not a factor in this case, but the point that serum magnesium should be monitored in such patients is valid. At the time of admission, abdominal examination of our patient revealed the presence of bowel sounds and no tenderness on several different examinations. There was no nausea, vomiting, or abdominal pain. It is unlikely that there was malabsorption of the oral potassium
Reports to the Membership
Journal: American Journal of Psychiatry (2015)

The following are edited/abbreviated versions of the annual reports of the APA Secretary-Treasurer, CEO and Medical Director, Speaker, and Speaker-Elect and the chairpersons of the APA Committee on Bylaws, Membership Committee, Committee of Tellers, and Elections Committee. The full reports were presented at the APA Annual Business Meeting in Toronto, May 17th, 2015.
Cefaclor Serum Sickness
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exercise and the heart
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral Toxicity of 1,1-Dichloroethylene in the Rat: Effects of Sex, Age, and Fasting
Authors: Melvin E. Andersen, Lawrence J. Jenkins
Journal: Environmental Health Perspectives (1977)

Mortality curves for groups of fasted male rats treated with single, oral doses of 1,1-dichloroethylene (1,1-DCE, vinylidene chloride) were not monotonically increasing sigmoids, but were complex with maxima or extended plateaus in the region of dose between 100 and 700 mg of 1,1-DCE/kg. The exact shape was a function of the size (age) of the rat used. When groups of rats of various sizes were dosed with 50 mg/kg, mortality and hepatotoxicity were greatest for those groups whose average weight was between 100 and 150 g. Smaller and larger male rats were less susceptible to 1,1-DCE intoxication. The toxicity of 1,1-DCE was less severe in female rats and there was no significant effect of rat size on 1,1-DCE toxicity in females. In rats of both sexes the dose dependence of the hepatotoxic response was complex, possessing a threshold level, a region of precipitous increase, and a plateau, where larger doses were ineffective in increasing hepatotoxicity. The threshold in male rats of 100–150 g occurred near 50 mg/kg, and for females it was closer to 100 mg/kg. Considered in their entirety these data suggest that 1,1-DCE is metabolized to a toxic intermediate via some saturable pathway. Based on the effects of pretreatment with microsomal enzyme inhibitors and activators on 1,1-DCE toxicity in rats of various sizes, it appears that there are at least two microsomal reactions involved in 1,1-DCE metabolism.
THE NEW CURE FOR TUBERCULOSIS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cases Illustrative of Prognosis in Heart-Disease
Authors: W. H. Broadbent
Journal: BMJ (1867)

Hemborough, and to the admirable manner in which the local anaes- thetic was employed by Dr. Richardson.In conclusion, a word or two as to after treatment, which, upon broad principles, should depend on the general condition of the patient, and the nature and severity of the symptoms.It is worthy of remark, that although five out of the nine cases lived for periods varying from two to eighteen days, not one died from the effects of abdominal or uterine inflammation, but from causes more or less interfering with, or taxing, the vital powers.This I con- ceive to be a most important fact, and one worthy of serious considera- tion.In the majority of the cases a supporting and cautiously stimulat- ing system was carried out from the first with good results; so much so, that I have strong reasons to believe, and those who watched some of the cases with me have expressed similar convictions, that had this plan been carefully and systematically followed out in all the cases recorded, I should have been enabled to place before you not one, but three, suc- cessful cases.
Abstract 10923: Indoxyl Sulfate Predicts the Presence of Polyvascular Disease in Patients With Coronary Artery Disease
Authors: Ippei Watanabe
Journal: Circulation (2015)

Introduction: Progression of chronic kidney disease (CKD) is associated with extending multiple damaged vascular beds. Data to evaluate the relevance of accumulated uremic toxin for systemic atherosclerosis is limited. In the present study we assessed the clinical role of serum indoxyl sulfate (IS), a protein-bound uremic toxin for the presence of polyvascular disease (PVD) in patients with coronary artery disease (CAD). Methods and Results: We analyzed clinical data from 94 patients who underwent percutaneous coronary intervention for CAD and the prevalence of PVD, defined as 1-, 2- or 3-vessel disease was preoperatively screened. Serum IS levels were determined from blood sample by using high performance liquid chromatograph. Receiver operator characteristic (ROC) curve was used for discriminative ability between elevated IS levels and the presence of PVD. The prevalence of PVD among CAD patients was 38%. The median value of serum IS was 0.103 mg/dl and IS levels were negatively correlated with estimated glomerular filtration rate (e-GFR) (r=0.66 p &lt;0.001). IS levels in PVD patients were significantly higher than in patients who had only CAD (1.171 ± 4.38 mg/dl vs 0.147 ± 0.144 mg/dl, p &lt;0.001) and ROC analysis determined serum IS levels of 0.142 mg/dl as a cut-off value to predict the presence of PVD (sensitivity: 73.4 %, specificity: 79.6%, the area under curve: 0.778). Multivariate analysis found IS (odds ratio [OR]: 6.77, 95% confidence interval [CI] : 1.84-24.9, p=0.003), e-GFR &lt;60 ml/min/1.73m 2 (OR: 5.74, 95% CI : 1.47-22.4, p=0.01) and diabetes mellitus (OR: 4.80, 95% CI: 1.40-16.4, p=0.01) were independently associated with the presence of PVD. Conclusions: IS is an independent predictor of PVD in patients with CAD. This result may contribute to understanding the mechanism of accelerated atherosclerosis in CKD.
LESIONS OF THE PANCREAS ASSOCIATED WITH CIRRHOSIS OF THE LIVER.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Embryotoxic Effects of Polybrominated Biphenyls (PBB) in Rats
Authors: Susan J. Harris, Helene C. Cecil, Joel Bitman
Journal: Environmental Health Perspectives (1978)

Pregnant Sprague Dawley rats were given 0, 0.25, 0.5, 1, 5, and 10 mg of a commercial polybrominated biphenyl, FireMaster BP-6 (PBB), in olive oil by gavage each day from days 7 through 15 of pregnancy. Laboratory chow and water were given ad libitum. Treatment with PBB had no significant effect on body weight gain, food and water consumption, and urine production. The mothers were killed on day 20, and the only significant effect observed was an increased liver weight of those given 1, 5, and 10 mg PBB. Spleen, kidney, ovarian, gravid uterine, and perirenal fat pad weights were similar to those of control mothers. PBB had no significant effect on number of live/dead fetuses, crown-rump length or fetal weight. No grossly malformed fetuses were observed in PBB-treated mothers. The effects of PBB transfer from mothers to nursing pups was studied by reciprocal exchange of pups between control mothers and mothers treated with 10 mg PBB. When the pups were 21 days old, they were weaned and fed control chow. The following four combinations of prenatal-postnatal exposure were studied: control-control (C:C); control-PBB (C:PBB); PBB-control (PBB:C); and PBB-PBB. Although the birth weights of pups from PBB-treated mothers were similar to those of the controls, body weights of 60-day-old males exposed prenatally and postnatally (PBB:C, C:PBB, and PBB:PBB) were less (p less than 0.05) than those of the controls (C:C). The weights of the perirenal fat pads of male and female pups exposed to PBB were less (p less than 0.05) than the control. Liver weights, on a body weight basis, were higher in male and female pups exposed to PBB. Vaginal openings were delayed; the percentages of 36-day-old pups with open vaginas were 50 (C:C), 38 (PBB:C), 28 (C:PBB), and 30 (PBB:PBB).
Vital Statistics
Journal: BMJ (1956)

for British Isles for week ending September 8 (No. 36) and corresponding week 1955.Figures of cases are for the countries shown and London administrative county.Figuires of deaths and bitrths are for the 160 great towns in England and Wales (London included), London administrative county, the 17 prtncipal towns in Scotland, the 10 principal townis in Northern Ireland, and the 14 principal towns in Eire.A blank space denotes disease not notifiable or no return available.The table ts based on informatton supplted by the Registrars-General of England and Wales, Scotland, N. Ireland, and Eire, the Ministry of Health and Local Governmenit of N. lrcland.and the Department of Health of Eite.CASES 1956 in Countries .
Seventh Meeting of the European Association for Cancer Research (EACR)
Journal: JNCI Journal of the National Cancer Institute (1982)

Seventh Meeting of the European Association for Cancer Research (EACR) Get access JNCI: Journal of the National Cancer Institute, Volume 69, Issue 6, December 1982, Pages 1421–1422, https://doi.org/10.1093/jnci/69.6.1421-e Published: 01 December 1982
Inherited Retinal Detachment
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A prospective study of hyperparathyroidism in individuals exposed to radiation in childhood
Authors: J. Cohen
Journal: JAMA (1990)

To determine the effects of childhood irradiation on the parathyroid glands, a cohort of 4297 patients who received radiation to the tonsils before the age of 16 years has been followed-up prospectively. Among the 2923 patients who were located and provided information, 32 patients developed clinical hyperparathyroidism. The incidence of clinical hyperparathyroidism was 18.7 per 100 000 person-years below the age of 40 years and 171 per 100 000 person-years in the age range of 40 to 60 years. This represents a 2.9-fold (95% confidence interval, 1.6 to 4.3) and 2.5-fold (95% confidence interval, 1.1 to 3.9) increase in the incidence of hyperparathyroidism compared with that among the general population. In addition, 31% of the patients who developed hyperparathyroidism also developed thyroid cancer, which is higher than the 11.2% prevalence of thyroid cancer in the patients who received radiation therapy who did not develop parathyroid tumors. Patients with a history of head and neck irradiation should have their parathyroid glands evaluated on a regular basis. (<i>JAMA</i>. 1990;264:581-584)