tbuckley/cabot-search huggingface dataset:
Hyperkalemia in Elderly Patients Receiving Standard Doses of Trimethoprim-Sulfamethoxazole
Authors: Leslye C. Pennypacker
Journal: Annals of Internal Medicine (1994)

Letters1 March 1994Hyperkalemia in Elderly Patients Receiving Standard Doses of Trimethoprim-SulfamethoxazoleLeslye C. Pennypacker, MD, Jacobo Mintzer, MD, and Janet Pitner, PharmDLeslye C. Pennypacker, MDMedical University of South Carolina; Charleston, SC 29425, Jacobo Mintzer, MDMedical University of South Carolina; Charleston, SC 29425, and Janet Pitner, PharmDMedical University of South Carolina; Charleston, SC 29425Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-5-199403010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with great interest the recently reported [1] association between high-dose trimethoprim-sulfamethoxazole therapy and hyperkalemia seen in patients with AIDS. Although our patient population differs substantially from that studied by Greenberg and colleagues [1], we have seen a similar clinical course evolve in an elderly, cognitively impaired patient who was being treated for a urinary tract infection. Our patient, a 76-year-old woman, presented with normal serum electrolyte levels (sodium, 136 mmol/L; potassium, 4.5 mmol/L; HCO3, 24 mmol/L; chlorine, 108 mmol/L; blood urea nitrogen, 23 mg/dL; and creatinine, 1.1 mg/dL) and no known history of renal, endocrine, ...REFERENCE1. Greenberg S, Reiser IW, Chou SY, Porush JG. Trimethoprim-sulfamethoxazole induces reversible hyperkalemia. Ann Intern Med. 1993; 119:291-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Leslye C. Pennypacker, MD; Jacobo Mintzer, MD; Janet Pitner, PharmDAffiliations: Medical University of South Carolina; Charleston, SC 29425 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byResponse to letter by Levine et al.Antimicrobial-Associated Renal Tubular AcidosisTrimethoprim-Induced HyperkalaemiaHyperkalemia in the elderlyHyperkalemia and Trimethoprim-SulfamethoxazoleAuthors' replyEffect of Standard-Dose Trimethoprim/Sulfamethoxazole on the Serum Potassium Concentration in Elderly MenSevere Hyperkalemia with Trimethoprim—QuinaprilSevere Hyperkalemia in a Geriatric Patient Receiving Standard Doses of Trimethoprim-SulfamethoxazoleSevere Hyperkalemia in a Geriatric Patient Receiving Standard Doses of Trimethoprim-SulfamethoxazoleCase Report: Reversible Hyperkalemia Associated With Trimethoprim-SulfamethoxazoleCotrimoxazole 1 March 1994Volume 120, Issue 5Page: 437-438KeywordsAntibioticsElderlyGeriatricsGlomerular filtration rateHospitalizationsKlebsiellaPotassiumSaltsSodium ePublished: 15 August 2000 Issue Published: 1 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Codeine and Addiction in Patients With Pain
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiation-Induced Nondisjunction
Authors: Irene A. Uchida
Journal: Environmental Health Perspectives (1979)

The methodology and results of epidemiological studies of the effects of preconception diagnostic x-rays of the abdomen on chromosome segregation in humans are described. Many studies have been conducted in a number of different countries. The vast majority show the same positive, though not significant, trend to increased nondisjunction among the offspring of irradiated women. The results of the various studies, however, cannot be pooled because of differing methodologies used. A worldwide co-operative project with standardized methodology is recommended. Such a study should identify the parental origin of the nondisjunctional event before etiological factors are investigated. Abnormal chromosome segregation during mitotic division has been inducted experimentally by the in vitro exposure of human lymphocytes to a low dose of 50 R gamma irradiation. First meiotic nondisjunction has been successfully induced by whole body exposure of female mice to a low dose of radiation. Further experiments are being conducted to try to induce abnormal segregation during second meiotic division. Because of difficulties encountered in trying to estimate total gonad doses resulting from differing techniques employed by radiologists and other health personnel, no attempt has been made to estimate the doubling dose nor minimum safe dose regarding the effects of radiation on chromosome segregation in humans. The question of time-related repair of the mechanism involved in chromosome segregation is raised.
Pharmacologic restraint vs therapeutic intent
Authors: R. Pies
Journal: JAMA (1991)

<h3>In Reply.</h3> —The thoughtful letter by Pies questions the appropriateness of equating pharmacologic restraint with a standing order for a major or minor tranquilizer or sedative-hypnotic drug. This is certainly a controversial area. As pointed out by Pies and noted in our "Comment" section, such medications have known therapeutic purposes. Therefore, their use does not necessarily constitute poor medical care. The difficulty in defining pharmacologic restraint is reflected by the fact that no specific medications or classes of drugs are mentioned in the wording of the Nursing Reform Act in the Omnibus Reconciliation Act of 1987. Current regulations involve only major tranquilizers, such as haloperidol. There is no doubt, however, that a variety of other medications are prescribed primarily to control patient behaviors and thus can be considered as pharmacologic restraint.<sup>1</sup> It must be remembered that in our study, all subjects were nursing home patients with Alzheimer's disease or
Care of the Critically III Patient
Authors: Richard W. Carlson
Journal: JAMA (1983)

The number of critical care textbooks and other volumes devoted to the acutely ill and injured is increasing at a rapid pace. This book, an ambitious and workmanlike treatment of the pathophysiology and management of critical illnesses and injury, is a result of the efforts of European and American authors. The editors have attempted to balance the views from each side of the Atlantic. The first section deals with applied physiology. Eight chapters are devoted to measurement and control of cardiac output, pulmonary ventilation and gas exchange, acid-base balance, and other aspects of physiology. In general, these are written clearly and are concise reviews rather than comprehensive treatments of each topic. The next section deals with cardiovascular disorders, including cardiopulmonary resuscitation, shock, pulmonary embolism, and hypertensive crises. In most instances, the authors present a good synthesis of these subjects with standard approaches to diagnosis and management. The editors have striven
Tobacco addiction and tobacco mortality. Implications for death certification
Authors: W. Pollin
Journal: JAMA (1984)

Addictive disorders now cause more than one fourth of all deaths in the United States—more than a half million deaths in 1982. But this essential fact is obscured in the nation's vital records and statistics by the general practice of certifying addictive disease deaths to their innumerable anatomic manifestations. However, this situation need not continue indefinitely. Physicians have both an opportunity and a responsibility to state their knowledge of the underlying causes of deaths occurring under their care, and the diagnostic category "Tobacco Use Disorder/Tobacco Dependence," listed in the ninth revision of the<i>International Classification of Diseases</i>is available for their use. By routinely ascertaining the lifetime smoking experience of each patient and stating on each death certificate the role of tobacco, physicians can contribute substantially to improvement of vital statistics, epidemiology, and public health. (<i>JAMA</i>1984;252:2849-2854)
Randomized prospective trial of noninvasive positive pressure ventilation in acute respiratory failure.
Authors: F Hawker, D Breen, P Torzillo, R Herkes
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

"Randomized prospective trial of noninvasive positive pressure ventilation in acute respiratory failure.." American journal of respiratory and critical care medicine, 153(3), pp. 1188–1189
Effect of Concentration and Cumulative Exposure of Inhaled Sulfuric Acid on Tracheobronchial Particle Clearance in Healthy Humans
Authors: Dalia M. Spektor, Bai M. Yen, Morton Lippmann
Journal: Environmental Health Perspectives (1989)

We have previously shown that 1-hr exposures to 0.5 microns sulfuric acid (H2SO4) mist at 100 and 1000 micrograms/m3 produced transient alterations of bronchial mucociliary clearance of monodispersed 7.6 and 4.2 microns mass median aerodynamic diameter gamma-tagged ferric oxide (Fe2O3) in healthy nonsmoking humans in a dose-dependent manner. To determine the role, if any, of the length of exposure, 10 healthy volunteers were exposed to 100 micrograms/m3 H2SO4 for 1 hr and 2 hr on separate occasions, 1 week apart, with measurements of their mucociliary clearance of 5.2 microns Fe2O3 particles inhaled both before and after the inhalation of the H2SO4. Their rate of bronchial mucociliary clearance was markedly reduced for both Fe2O3 aerosols, with slower clearance of the aerosol inhaled after the H2SO4 exposure. For the tagged Fe2O3 aerosol inhaled after exposure for 2 hr at 100 micrograms/m3 H2SO4, the tracheobronchial clearance halftime, (T50), tripled from control, and the reduced rate of clearance was still evident 3 hr after the end of exposure. The 1-hr 100 micrograms/m3 H2SO4 exposure doubled T50 from control, and the reduced rate of clearance lasted for about 2 hr after the end of exposure. These results indicate that the effect of doubling the length of exposure was as great or greater than an order of magnitude increase in the concentration of H2SO4.
Special Article.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Death
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Epigenomics of Idiopathic Pulmonary Fibrosis: Evaluating the First Steps
Authors: Ze-Zhou Song
Journal: American Journal of Respiratory and Critical Care Medicine (2015)

It was with great interest that I read the article by Trimble and colleagues (1), which concluded that CXCR4 1 fibrocyte concentration could be predictive of the outcome of interstitial lung diseases in patients with Hermansky-Pudlak syndrome.It is well known that a complex array of factors could regulate fibrocyte biology.For example, fibrocyte differentiation was inhibited in culture within serum-enriched media because a stable serum protein, serum amyloid P, could inhibit fibrocyte differentiation (2).Therefore, the levels of circulating fibrocytes could be affected by the levels of serum amyloid P. In addition, low-molecular-weight heparin had antifibrotic effects despite its nonanticoagulant activities and could affect the levels of circulating fibrocytes (3).In the study by Trimble and colleagues (1), however, the abovementioned factors that could affect the levels of circulating fibrocytes were not described in detail.Further studies should be performed without the abovementioned factors.
Diagnosis of vascular disease by photoelectronic intravenous angiography
Authors: B. J. Hillman
Journal: JAMA (1981)

RECENT developments in medical diagnostic imaging have concentrated on diminishing patient risk and discomfort, evidenced by the general acceptance of computed tomography (CT) and ultrasonography for the routine evaluation of patients' conditions. The need for more invasive procedures, such as angiography, has diminished and pneumoencephalography has almost disappeared.<sup>1-3</sup>Nonetheless, these new techniques thus far have proved insufficient for accurate imaging of most major vascular diseases. Thus, the diagnosis and planning for treatment of such common disorders as atherosclerosis and vascular dysplasias continue to require arteriography. To supercede the objectionable qualities of angiography—hospitalization, loss of work days, patient discomfort, risk of morbidity, and high financial cost—the authors have developed during the past five years a photoelectronic radiology system for performing angiography following an intravenous injection of contrast medium. This method of photoelectronic intravenous angiography (PIA) can be performed on outpatients, is low in cost, and provides excellent information concerning the
Cyclotrons and radiopharmaceuticals in positron emission tomography. Council on Scientific Affairs. Report of the Positron Emission Tomography Panel
Journal: JAMA (1988)

Positron emission tomography (PET) can probe biochemical pathways in vivo and can provide quantitative data; for that purpose, tracers labeled with positron-emitting radioisotopes are essential. This report describes the tracers that are being used or that may have future use, their production by cyclotrons, and other needed resources for PET imaging. Current routine and automated methods for convenient production of labeled compounds, coupled with simple computer-controlled accelerators, can support the creation of clinical PET centers in any large medical institution, obviating the need for in-depth research teams. An alternate approach involves the development of regional centers that provide in-house service and that supply fluorine 18- and carbon 11-labeled compounds to nearby hospitals with PET machines.
Nausea, vomiting, and epigastric pain in an elderly diabetic
Authors: M. Medero
Journal: JAMA (1985)

A 61-year-old man presented with the complaints of nausea, vomiting, and severe epigastric pain. An anteroposterior roentgenogram of the abdomen demonstrated a conclusive diagnostic finding. <h3>History</h3> The patient was a noncompliant, poorly regulated diabetic receiving 54 units of isophane insulin (NPH [neutral protamine hagedorn] insulin) and 20 units of insulin by subcutaneous injection daily. His medical history was significant for multiple sequelae of diabetes. On physical examination, he was febrile (temperature, 38.5 °C), alert, and in no apparent distress. His abdomen was moderately distended, tender, and had normal bowel sounds. Laboratory findings included an elevated serum glucose level of 345 mg/ dL, urine glucose concentration of 3%, and white blood cell count of 19,000/cu mm. Roentgenograms of the chest and abdomen demonstrated radiological findings that will be described subsequently (Fig 1). (To the reader: Observe the area of the stomach with extra care.) <h3>Diagnosis</h3> Gastric emphysema associated with gastroparesis in
PMO-169 Pegylated interferon α, Nitazoxanide, Telapravir, Ribavirin, in genotype 1 undergoing prior experienced chronic hepatitis C patients: a randomised placebo control clinical pilot trial (I N T R I G U E C) interim
Authors: P Basu, T Nair, S Farhat, M Jafri, K Mittimani, N James Shah, L Ang, S foustin
Journal: Gut (2012)

<h3>Introduction</h3> Chronic hepatitis C is a global challenge with end stage liver disease and rising Hepatocellular Carcinoma. Peg Interferon α and Ribavirin was the backbone of therapy. Recently introduced Directly Acting Antivirals -protease inhibitor has a promising role in escalating Sustained Viral Response in Response guided therapy in non-responders, partial and relapses. This study utilised Nitazoxanide (NTZ) and Telapravir, with SOC for 24 weeks in treatment experienced patients. <h3>Methods</h3> 50 (n=50) patients were divided into Group A (n=12) NTZ 500 mg three times for 12 weeks, Group B (n=12) NTZ 500 mg twice daily for 24 weeks Group C (n=26) control. All received Peg Interferon α 2a 180 μg SQ QOW with fixed dose of Ribavirin 1200 mg daily for 24 weeks with Telapravir 750 mg three times daily for 12 weeks. Viral load was obtained at day 0, 7th day, 14th day, 4 weeks, 12th week and 24 weeks. Viral kinetics was analysed. In Group A: 5/12 (42%) Non-Responder, 6/12 (50%) partial responder, 2/12 (16%) relapsers. In Group B: 5/12 (42%) Non-responders, 6/12 (50%) partial responder, 1/12 relapsers (8%). In Group C: 10/26 (38%) non-responder, 10/26 (38%) partial responder, 4/26 (15%) relapsers, 2/26 (8%) unknown. Exclusion: Decompensated Cirrhotic, HCC, poor DM, Haemolytic Anaemia, Severe Coronary artery disease, major depression, renal failure, Prior severe skin rash, active drug and alcohol abuse. Side Effects: Anaemia 28/50 (56%), Neutropenia 14/50 (28%), Thrombocytopaenia 8/50 (16%), Fatigue 34/50 (68%), Depression 10/50 (20%), Mild skin rash 22/50 (44%), Severe skin rash 1/50 (2%). Use of Growth factors: Epogen 12/50 (24%) Neupogen 8/50 (16%) Elthrombopag 5/50 (10%). <h3>Results</h3> <h3>Conclusion</h3> This quadruple truncated regimen has excelled the RVR, ETVR over SOC with Directly Acting Antivirals over 13%, without any difference between 24 weeks of NTZ over 12. Needs a larger trial for validation. <h3>Competing interests</h3> None declared.
Forced Expiratory Volume (FEV0.75) in Healthy Males and in Textile Workers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic kidney disease in primary care
Authors: Prabir Kumar Mitra, John R Bradley
Journal: Journal of the Royal Society of Medicine (2007)

It has been estimated that chronic kidney disease (CKD) affects about one in 200 of the population in the UK. There is an increased awareness of the need to identify patients in primary care with CKD at an earlier stage, so that treatments can be initiated to delay progression and prevent complications and appropriate nephrological referral can be made. In this article we will review how measures to identify patients with CKD can improve its management.