tbuckley/cabot-search huggingface dataset:
Velour trial biomarkers update: Impact of RAS, BRAF, and sidedness on aflibercept activity.
Authors: Pratyaksha Wirapati, Valentina Pomella, Ben Vandenbosch, Peter Kerr, Evaristo Maiello, Grahame Mark Jeffery, Razvan-Ovidiu D. Curca, Meinolf Karthaus, John A. Bridgewater, Anca C. Mihailov, Igor Kiss, Sandra Merino, Joseph James McKendrick, Zacharenia Saridaki, Xavier JA Sagaert, Sabine Tejpar
Journal: Journal of Clinical Oncology (2017)

3538 Background: Addition of (ziv)-aflibercept (A) to FOLFIRI in second-line therapy for metastatic colorectal cancer (CRC) has been shown to be beneficial in phase III VELOUR trial (NCT00561470). A follow-up study (NCT01754272) was undertaken to acquire tumor samples for biomarker analyses and identify subgroups of patients with differential treatment effects. The primary results assessing efficacy according to well-established CRC subgroups defined by RAS, BRAF status and sidedness are reported here. Methods: Tissue specimens were collected for 666 patients from 1226 ITT pts. Suitable specimens were assayed for somatic mutation using NGS targeting extended RAS and BRAF genes. NGS assays with no missing values were obtained for 482 pts. Affymetrix gene chip technology was used for whole-transcriptome profiling; sidedness was extracted from available pathological reports. Differences between subgroups were assessed by interaction analysis. Results: The treatment effects on overall survival (OS) for the 482 pts is still significant HR=0.80 (CI 0.65-0.99), and similar to the ITT (n=1226) results (HR=0.82, CI 0.71-0.93). Two established ways of defining mutations (traditional KRAS exon 2 and extended RAS using NGS) show a trend for a differential effect across mutation groups.(see table for OS). Interestingly, BRAF mutants (which are all RAS wild type) show a trend for better outcome Same is seen for PFS and RR. Sidedness did not affect efficacy (HR: 0.83 (0.63- 1.1) for left and HR: 0.83 (0.54-1.3) for right. Conclusions: None of the mutations subgroup results shows significant interaction, although the ratios of treatment HR favor RAS wild types. Similar trends were observed in published trials with bevacizumab or ramucirumab. Sanofi supported this ISS. Clinical trial information: NCT01754272. [Table: see text]
Blood Cholesterol Measurement in Young Adults-Reply
Authors: Stephen B. Hulley
Journal: JAMA (1993)

<h3>In Reply.</h3> —We agree with Dr Tobert that the small number of deaths in the EXCEL trial precludes firm conclusions about the impact of lovastatin on mortality, but we take little comfort from his comments on cause of death. The fact is that a higher proportion of lovastatin-treated patients died. It is disturbing that this large study funded by Tobert's employer had only 1 year of follow-up, and that it is the only randomized trial of this drug with published disease event outcomes. This leaves us in the position of hoping that other trials will show that death rates decrease and keeping our fingers crossed in the meantime. Such uncertainty about a new class of drugs that is already widely used seems unacceptable, raising questions about the use of surrogate end points by Food and Drug Administration advisory panels to recommend long-term drug treatment for healthy people. As to Dr
Antidiarrheal Effect of Antibiotics
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differentiation between physiologic and incipient pathologic left ventricular hypertrophy. Study with tissue doppler Jos� L. Zamorano, Carlos Almeria, Ra�l Moreno, Walter Taua, Adalia Aubele, Luis Mataix, Jos� L. Rodrigo, Luis Sanchez-Harguindey. Hospital Clinico San Carlos, Madrid, Spain
Journal: Journal of the American College of Cardiology (2001)
Ocular Manifestations of Hereditary Dystopic Lipidosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiple blinded reviews of the same two manuscripts. Effects of referee characteristics and publication language
Authors: M. Nylenna
Journal: JAMA (1994)

<h3>Objective.</h3> —To study the association between referee characteristics and their manuscript assessments, the influence of manuscript language on referees' judgments, and the usefulness, quality, and extent of referees' free-text comments. <h3>Design.</h3> —Two nonauthentic, but realistic, short manuscripts with a number of common methodological flaws were sent to 180 Scandinavian referees. Through randomization, each referee received one of the manuscripts in English and the other manuscript in the national language. A structured assessment of the manuscript quality was expressed on a 5-point scale, and the impact of referee characteristics (age, gender, experience, and so on) was analyzed by multiple linear regression. <h3>Main Outcome.</h3> —Manuscript quality assessed by referees. <h3>Results.</h3> —A total of 312 reviews from 156 referees could be used for the study of referee characteristics and language. With increasing experience, the referees gave lower quality scores (<i>P</i>&lt;.05). A tendency toward stricter assessment with younger age was seen (<i>P</i>&lt;.05). No influence of referees' gender, specialty, or nationality was found. For the test manuscript of the poorest quality, the English version was assessed to be better than the national-language version (<i>P</i>&lt;.05). A total of 159 of 312 reviews included free-text comments applicable for the methodological study. In 54 reviews (34%), no methodological comments accompanied the assessment, and in six reviews they were only incomplete. Wrong sampling unit was mentioned by one fourth of 80 referees. Only one referee mentioned the incorrect use of a parametric test in the analysis of data whose distribution was nonparametric. <h3>Conclusions.</h3> —Experienced and young referees gave a stricter assessment of the manuscripts than their less experienced and older colleagues. An English version seemed to be accepted more easily than a national-language version of the same manuscript. Most referees spontaneously mentioned the shortcomings of the manuscripts only as part of their overall judgment. (<i>JAMA</i>. 1994;272:149-151)
Mitochondrial DNA studies help identify lost victims of human rights abuses
Authors: A. A. Skolnick
Journal: JAMA (1993)

MITOCHONDRIAL DNA (mtDNA) extracted from the teeth and bones buried in clandestine graves is allowing investigators to identify victims of government-sanctioned murder in several countries. By comparing mtDNA sequences of possible living relatives with DNA extracted from teeth found in two mass graves in Guatemala, T. Christian Boles, PhD, assistant professor of biochemistry, Brandeis University, Waltham, Mass, is helping forensic anthropologists confirm the identities of five of the victims. The skeletons are believed to be the remains of 12 men who were taken from the village of San Jose Pachó Lemoa by a "civilian patrol" the night of February 14, 1982. The next morning, villagers found what appeared to be two freshly dug graves in a nearby ravine. For more than 10 years after the massacre, the villagers did not disturb the graves, nor did they talk about the disappearance of the men or the gunshots they heard during that
Dismounted IED
Authors: Heather C. Yun
Journal: Annals of Internal Medicine (2012)

Ad Libitum21 August 2012Dismounted IEDHeather C. Yun, MDHeather C. Yun, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-4-201208210-00017 Audio Reading - “Dismounted IED” Audio. Listen to a reading of "Dismounted IED" by Heather C. Yun, MD. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail She asks for an ABG before extubating bed 9Ineffective stalling tactic, but I affirmMinutes later, it is complete, perfect.Awake, clear eyed, wants the tube out,Two thumbs up, denies pain;This conversation unavoidable today.We chat. Red cheeked, sandy hair, twenty-threeTorso corn-fed, fresh inspirational tattoos.He chuckles, confesses the pirate peg-legHis buddy envisioned for this occasion.Sam plans to get two.Were you awake at Kandahar, what do you know?He saw the splintering thigh bonesLower body covered with a pillowcase.Right arm broken, left hand degloved.What do you know of your genital injuries?Terror falls; the answer is obvious.The good news ... Author, Article, and Disclosure InformationAffiliations: Disclaimer: The content of this publication is the sole responsibility of the author and does not necessarily reflect the views or policies of the U.S. Department of the Army, the U.S. Department of the Air Force, the U.S. Department of Defense, or the U.S. government.Current Author Address: Heather C. Yun, MD; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Dismounted IED” Audio. Listen to a reading of "Dismounted IED" by Heather C. Yun, MD. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 21 August 2012Volume 157, Issue 4Page: 298KeywordsBoneFallsGenital anatomyPenisPharynx ePublished: 21 August 2012 Issue Published: 21 August 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Bladder Neoplasms
Authors: Gerald P. Murphy
Journal: JAMA (1983)

Edwin Beer made many contributions to the study of bladder cancer. We are indebted to him for the summary of his work at the Mount Sinai Hospital published in 1935.<sup>1</sup> Looking back in that volume on his contributions to the control of bladder cancer, Beer felt that the first advance in operative therapy had been introduced by Billroth in 1874. At the time, urologic surgeons relied on either blind transurethral manipulation or lateral perineal incisions for the removal or excision of bladder tumors. Billroth often employed a suprapubic incision and first removed a bladder tumor under direct visual control. Despite the proven validity in this approach, by 1885 only nine bladder tumors had been removed in this way, according to a review by Antal that was cited by Beer in 1935.<sup>1</sup> Beer believed that the operative approach to removal of bladder cancer was developing according to two schools
Carbidopa
Authors: A. Curtis True
Journal: JAMA (1976)

<h3>To the Editor.—</h3> It was mentioned inTrends in Therapy(233:1198-1201, 1975) in a discussion of the individualization of drug therapy for the parkinsonian patient that decarboxylase inhibitors are still experimental in the United States. While undoubtedly true when this paper was accepted for publication, I would like to point out for the information of your readers that the dopa decarboxylase inhibitor, carbidopa, is now available in combination with levodopa as Sinemet supplied by Merck Sharp &amp; Dohme.
Hematology
Authors: Ernest Beutler
Journal: JAMA (1981)

<h3>The Cure of Acute Leukemia in Adults: Beginnings</h3> In the summer of 1927, a 49-year-old businessman from New York consulted Dr W. Gloor, in Naegeli's Clinic in Zürich, Switzerland. He had typical acute leukemia with a WBC count of 102,400/cu mm, with 93% myeloblasts. Bleeding, fever, and splenomegaly rounded out his clinical picture. Treated with the relatively crude, ineffective agents available at the time—radiation, arsenic, and mesothorium—his illness took a surprising turn. The leukemia disappeared and the businessman returned home. On a return visit to Switzerland a year later, he was free of disease.<sup>1</sup>One might imagine that this striking therapeutic success firmly established the young physician's reputation. But alas, this was not the case. The experts of the time could conclude only that he had made a mistake in diagnosis, and Dr Gloor left the university to practice at a hospital in a small canton. Until recently, our
SIR WM. TURNER DECLINES.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PLoS Medicine Issue Image | Vol. 3(8) August 2006
Journal: PLoS Medicine (2006)

The cover is based on a brain MRI scan of a child with obstructive sleep apnea, which most commonly occurs when children are very overweight. The related research article by Halbower et al. suggests that children with obstructive sleep apnea may also have changes in their brain metabolism, which could make them more likely to have learning difficulties. Image Credit: Images taken from Halbower et al.
Pulmonary Syphilis.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: Judith Leet
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolism of cholesterol and low- and high-density lipoproteins in primary biliary cirrhosis: cholesterol absorption and synthesis related to lipoprotein levels and their kinetics*1, *2
Authors: H GYLLING
Journal: Hepatology (1995)

Cholesterol absorption, elimination, and synthesis, and low-density lipoprotein (LDL) and high density lipoprotein (HDL) kinetics were studied in patients with mild to severe primary biliary cirrhosis (PBC) (n = 16) to show how this cholestatic disease modified cholesterol and lipoprotein metabolism as compared with healthy controls (n = 50). Serum total and lipoprotein cholesterol and triglyceride levels were similar in the two groups, but in PBC, especially in severe forms, very low density lipoprotein (VLDL) was rich in apoprotein (apo) B and cholesterol and low in triglycerides, whereas LDL was rich in triglycerides and low in esterified cholesterol, and HDL was enriched by surface lipids, phospholipids, and free cholesterol. In severe PBC, the fractional catabolic rate (FCR) for LDL apo B was reduced. The transport rate (TR) for LDL apo B was unaffected and it tended to correlate with the LDL apo B and LDL cholesterol levels in PBC, whereas in the controls the LDL apo B concentration was regulated by both the FCR and TR, and LDL cholesterol was regulated only by FCR. FCR for apo A-I in HDL was unaltered in PBC, but TR for apo A-I was reduced in the severe cases. Cholesterol absorption efficiency was significantly reduced in PBC (14.5 ± 3.0% in severe PBC and 34.0 ± 2.5% in mild PBC vs. 47.4 ± 1.4% in the controls, respectively). Bile acid synthesis and cholesterol transport were significantly diminished in PBC, but, even in a case with severe PBC and low basal absorption efficiency and synthesis of cholesterol, lowering of LDL cholesterol by combined inhibition of hydroxymethyl-glutaryl-coenzyme A reductase and cholesterol absorption, removal of LDL apo B could still be upregulated. The significant interrelations between the LDL apo B level, cholesterol absorption efficiency and synthesis, and LDL apo B kinetics, observed in the controls, were lacking in PBC, suggesting that cholestasis and hepatic parenchymal cell dysfunction modified the relationship between cholesterol and lipoprotein metabolism so that treatment of hypercholesterolemia and bile acid-related itching might not be constantly successful.
French Medicine
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal