tbuckley/cabot-search huggingface dataset:
Acute myocardial infarction in a pregnant woman at term
Authors: W. R. Cohen
Journal: JAMA (1983)

MANIFESTATIONS of arteriosclerotic cardiovascular disease are rare in pregnant women. We describe a case of acute myocardial infarction in a woman at 39 weeks' gestation. General guidelines for management of pregnancy associated with this complication are suggested. <h3>Report of a Case</h3> A 42-year-old woman (gravida 7, para 6) had a massive anterior-wall myocardial infarction within the 39th week of an otherwise normal pregnancy. Shortly after the onset of her first episode of chest pain, she sustained ventricular fibrillation and was resuscitated successfully. Twenty-four hours later, after severe postarrest congestive heart failure was treated, she was transferred to Beth Israel Hospital, Boston. The patient's first pregnancy had been complicated by preeclampsia, but her others had been uneventful. She had a 20-year history of mild hypertension (treated intermittently with diuretics and propranolol hydrochloride), a five-pack-year smoking history, and a family history of arteriosclerotic cardiovascular disease. Results of her serum lipid profile were
Fourteenth Biennial Report of the State Board of Health of California, for the fiscal years from June 30, 1894, to June 30, 1896. Also, the Transactions of the Fourth Annual Sanitary Convention held at Los Angeles, April 20, 1896.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Euthanasia and suicide in antiquity: viewpoint of the dramatists and philosophers
Authors: J. D Papadimitriou, P. Skiadas, C. S Mavrantonis, V. Polimeropoulos, D. J Papadimitriou, K. J Papacostas
Journal: Journal of the Royal Society of Medicine (2006)

‘It is not the death I fear to face but dying.’
The family practice concept debated
Authors: M. Ross
Journal: JAMA (1978)

<h3>In Reply. —</h3> According to the letter from Dr Ross, the trend to educate family physicians is potentially harmful. Unfortunately, this typifies the "emotional rhetoric" that so frequently clouds the issues related to family practice. So many of the arguments pro and con are opinion, but expressed as fact, and prejudices based on anecdotal experience, not an informed view. Although it is tempting for me to respond to each of Dr Ross's assumptions, to ask for supporting data and/or provide information that would contradict his statements, I will limit myself to the following: <h3>1. Omniscience is a prerequisite to practice family medicine.—</h3> No one with whom I have spoken and who is a family physician or is involved in educating prospective family physicians believes the generalist can "know it all." This is a cruel fallacy. Those physicians who feel they should know it all fail to understand the selectivity that
Commentaire de travail de L. A. S. van Kerkhoven et al., pp. 502
Journal: Endoscopy (2007)

See also: Is there any association between referral indications for open-access upper gastrointestinal endoscopy and endoscopic findings?Endoscopy 2007; 39(06): 502-506DOI: 10.1055/s-2007-966269
Rx: traveling museum exhibit to be taken ad lib
Authors: A. A. Skolnick
Journal: JAMA (1997)

A UNIQUE museum exhibition of the past, present, and future of pharmaceuticals is touring the United States to boost the public's understanding of medicine and inspire the next generation of medical scientists. The traveling exhibition,<i>Medicines: The Inside Story</i>, is now at the Museum of Science and Industry in Chicago, Ill, where it will remain through May before moving to the California Museum of Science and Industry in Los Angeles. Using state-of-the-art multimedia technology, the exhibit takes visitors on a journey through 5 generations of pharmaceutical development to improve their understanding of what a medication is and how it works inside the body, says Elliott Sogol, PhD, RPh, project coordinator and corporate liaison for Glaxo Wellcome, Inc, the Research Triangle Park, NC—based pharmaceutical company that is sponsoring the project. The exhibit also features the most extensive display of artifacts ever assembled to chronicle the history of pharmaceuticals, explain present use,
Übersicht der gebräuchlichen und neueren Arzneimittel für Ärzte, Apotheker und Zahnärzte
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wants it Published.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3563: Exosomal transfer of tumor-associated macrophage derived miR-6068 promote ovarian cancer progression
Authors: Seyda Baydogan, Jianting Sheng, Nermin Kahraman, Pinar Kanlikilicer, Hamada Ahmed Mokhlis, Sayra Dilmac, Stephen T. C. Wong, Bulent Ozpolat
Journal: Cancer Research (2019)

Abstract Ovarian cancer, especially high-grade serous ovarian cancer (HGSOC), is the deadliest gynecological cancer with 50-70% 5-year mortality rates. Every year more than 22,000 new cases of ovarian cancer and 15,000 deaths are anticipated within the United States only. Recent clinical and experimental evidence indicates that tumor-associated macrophages (TAMs), the most abundant cells in the tumor microenvironment, play a significant role in tumor growth and progression by contributing to angiogenesis, invasion, metastasis, and drug resistance, leading to poor clinical outcomes and significantly shorter patient survival in HGSOC. More than 50% of cells in the peritoneal tumor microenvironment and malign ascites consist of TAMs in ovarian cancer (OC) patients. Especially, M2 macrophages have been shown to support tumor proliferation and promote tumor progression, angiogenesis, and drug resistance. But the mechanisms of these oncogenic effects are still not clear. The goal of our study to investigate the role of TAM-derived exosomes, which are 30-100nm microvesicles released from cells and are key factors in communication between cancer cells and the tumor microenvironment. To this end, we evaluated differentially expressed miRNAs in high-grade ovarian cancer cells (OVCAR3, OVCAR 432 and OVCAR5) after treatment with exosomes-derived from TAMs (M2 phenotype) using the Affymetrix Gene Chip miRNA 4.0 microarrays. We identified several miRNAs, including miR-6068 that we validated by qPCR and found it to be significantly upregulated in both HGSOC cells and their exosomes. We demonstrated that transfection of HGSOC cells with miR-6068 significantly increased proliferation, migration and invasion capacities of the cells in vitro, suggesting that this miR-6068 act as an oncogenic miR (oncomiR). Using in silico prediction algorithms we found that miR-6068 has binding sites on the 3’-untranslated region (3’-UTR) of PTPN4 gene encoding a phosphatase and demonstrated that it miR-6068 suppresses PTPN4 expression by Western blot and qPCR. Inhibition of PTPN4 by siRNA significantly induced cell proliferation in OC cells, suggesting that PTPN4 acts as a tumor suppressor. In conclusion, our results suggest that miR-6068 has an oncogenic role in ovarian cancer progression by targeting PTPN4 and may be a novel effective therapeutic target for ovarian cancer. Citation Format: Seyda Baydogan, Jianting Sheng, Nermin Kahraman, Pinar Kanlikilicer, Hamada Ahmed Mokhlis, Sayra Dilmac, Stephen T. C. Wong, Bulent Ozpolat. Exosomal transfer of tumor-associated macrophage derived miR-6068 promote ovarian cancer progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3563.
Coordinate regulation of sterol 27-hydroxylase, cholesterol 7?-hydroxylase, and HMG-CoA reductase in the hamster Z.R. Vlahcevic1, W.M. Pandak1, M. Doerner1, P.B. Hylemon2, and D.M. Heuman1. Depts. of Medicine1 and Microbiology2, McGuire VAMC and Medical College of Virginia-VCU, Richmond, VA
Journal: Hepatology (1995)

I have been involved in research on oxysterols since 1963 and this review is intended to cover some of the most important aspects of this work.The first project dealed with 7α-hydroxy-4-cholesten-3-one. My successful synthesis of this steroid with high specific radioactivity allowed a demonstration that it is a bile acid precursor. The mechanism of conversion of 7α-hydroxycholesterol into 7α-hydroxy-4-cholesten-3-one was investigated and I concluded that only one enzyme is required and that no isomerase is involved. Accumulation of 7α-hydroxy-4-cholesten-3-one in patients with lack of sterol 27-hydroxylase (Cerebrotendinous xanthomatosis was shown to be an important pathogenetic factor. This disease is characterized by cholestanol-containing xanthomas in tendons and brain and we could show that most of this cholestanol is formed from 7α-hydroxy-4-cholesten-3-one. We also showed that 7α-hydroxy-4-cholesten-3-one passes the blood–brain barrier.In contrast to cholesterol itself, side-chain oxidized oxysterols have a high capacity to pass lipophilic membranes. We demonstrated conversion of cholesterol into 27-hydroxycholesterol to be a significant mechanism for elimination of cholesterol from macrophages. We also showed that conversion of cholesterol into 24S-hydroxycholesterol is important for elimination of cholesterol from the brain.Side-chain oxidized oxysterols have a high capacity to affect critical genes in cholesterol turnover in vitro. Most of the published in vitro experiments with oxysteroids are highly unphysiological, however. Mouse models studied in my laboratory with high or low levels of 27-hydroxycholesterol have little or no disturbancies in cholesterol homeostasis. 24S-hydroxycholesterol is an efficient ligand to LXR and suggested to be important for cholesterol homeostasis in the brain. We recently developed a mouse model with markedly increased levels of this oxysterol in circulation and brain. This overexpression had however only a very modest effect on cholesterol turnover.We concluded that oxysterols are not the master regulators of cholesterol homeostasis in vivo suggested previously.
Impaired Oxygenation in Surgical Patients During Anesthesia With Controlled Ventilation: A Concept of Atelectasis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IS EPIDEMIC POLIOMYELITIS PREVALENT IN ENGLAND AND FRANCE?
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MASSIVE COLLAPSE OF THE LUNG
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of positive crossmatch due to IgG versus IgM antibodies on the outcome of primary liver transplantation under tacrolimus Dept. of Surgery, University of Pittsburgh Medical Center, Pittsburgh
Journal: Hepatology (1995)

Hypothermic machine perfusion (HMP) of kidneys is intended to mitigate the deleterious effects of cold storage on organ quality, particularly when the cold ischemic time is prolonged or the donor is otherwise marginal. The use of HMP has remained controversial; however, a number of randomized controlled trials (RCTs) have recently been conducted to clarify its benefits.We undertook a systematic search of the Medline and Embase databases and of the Cochrane Central Register of Controlled Trials. We included only RCTs in the meta-analysis. Outcomes analyzed were the incidence of delayed graft function (DGF), primary nonfunction (PNF), graft loss, and patient death at 1 y.We identified seven RCT trials and subjected them to meta-analysis, including 1353 kidney transplant recipients. Hypothermic machine perfusion significantly reduced the incidence of DGF (risk ratio [RR] 0.83, 95% confidence interval [CI] 0.72–0.96). There was no difference in the incidence of PNF (RR 0.78, 95% CI 0.36–1.68), graft loss at 1 y (RR 0.87, 95% CI 0.64–1.19), and patient death at 1 y (RR 0.91, 95% CI 0.60–1.37) between HMP and donor kidneys preserved using cold storage.There are few RCT comparing HMP and cold storage of kidneys in deceased donor kidney transplantation. Although these studies are small and heterogeneous in design, HMP appeared to be associated with a reduced incidence of DGF. No difference in the incidence of PNF, graft loss, or patient death at 1 y could be demonstrated.
Diabetic Retinopathy
Authors: David A. Antonetti, Ronald Klein, Thomas W. Gardner
Journal: New England Journal of Medicine (2012)

The incidence of diabetes is increasing, but that of diabetic retinopathy is falling, probably owing to better management of glucose levels, lipid abnormalities, and hypertension. Clinical trials of VEGF and PPAR-α inhibitors are improving vision and providing insights into pathogenesis.
In Vivo Genetic Mutations Define Predominant Functions of the Human T-Cell Leukemia/Lymphoma Virus p12I Protein.
Authors: Genoveffa Franchini, Risaku Fukumoto, Vibeke Andresen, Izabela Bialuk, Valentina Cecchinato, Jean Claude Walser, Valerio William Valeri, Julie M Nauroth, Antoine Gessain, Christophe Nicot
Journal: Blood (2008)
Fellowship, Grants, Awards
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Fellowship, Grants, Awards Get access JNCI: Journal of the National Cancer Institute, Volume 84, Issue 18, 16 September 1992, Pages 1451–1452, https://doi.org/10.1093/jnci/84.18.1451 Published: 16 September 1992
The Association and the Colleges.
Authors: T. J. Happel
Journal: JAMA (1898)

Trenton, Tenn., Sept. 12, 1898. <h3>To the Editor:</h3> —I have before me Dr. D. S. Reynolds' reply to my note on page 547 of theJournal. When I presided over theAssociationin Denver, I acted<i>then</i>in my official capacity;<i>now</i>I am only a member of theAmerican Medical Association, and as such have a right to criticise any of its actions. In the hurry of business, a presiding officer puts such motions as are made, if they are not plainly out of order, when no point of order is made against them, just as was done in the resolutions offered by Dr. Hare in regard to the admission of the members from the State of New York, who were not in affiliation with the recognized Society in that State. The question was discussed at some length before the point of order was made against it that it
OZENA
Authors: M. M. CULLOM
Journal: JAMA (1941)

Ozena is called also atrophic rhinitis, atrophic catarrh, coryza foetida and sclerotic rhinitis. However, the favorite and common term is "the opprobrium of medicine." The Germans, with their genius for expressing delicate shades of meaning and their natural use of euphemistic terms, call it "stink nose." Because of the voluminousness of the literature, this review will be limited to the etiology. The report to the Madrid congress by Leroux-Robert and Costiniu<sup>1</sup>contains one hundred and seventeen pages, and a total of two hundred and seventy-nine papers are listed, mostly by continental authors and mostly written since 1920, have appeared in the literature. If the true cause of ozena is ascertained, this most distressing disease, with all its pathologic and social implications, may well be eliminated. St. Clair Thomson<sup>2</sup>has succinctly stated that ozena is a chronic rhinitis characterized by atrophic changes in the nasal mucosa and the turbinal
The Future of Adult Cardiology
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tenth Annual Frederick Stohlman Memorial Symposium
Journal: JNCI Journal of the National Cancer Institute (1984)

Tenth Annual Frederick Stohlman Memorial Symposium Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 4, April 1984, Page 964, https://doi.org/10.1093/jnci/72.4.964-b Published: 01 April 1984