tbuckley/cabot-search huggingface dataset:
A Transplantable Osteogenic Sarcoma Originating in a C3H Mouse
Journal: JNCI Journal of the National Cancer Institute (1944)

Journal Article A Transplantable Osteogenic Sarcoma Originating in a C3H Mouse Get access Morris K. Barrett, Morris K. Barrett formerly research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Albert J. Dalton, Albert J. Dalton cytologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse E. Edwards, Jesse E. Edwards formerly research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse P. Greenstein, Jesse P. Greenstein senior biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia C. Briggs Virginia C. Briggs National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 4, February 1944, Pages 389–402, https://doi.org/10.1093/jnci/4.4.389 Published: 01 February 1944
Ibuprofen-induced meningitis in systemic lupus erythematosus
Authors: H. L. Widener
Journal: JAMA (1978)

A patient with systemic lupus erythematosus had chills, fever, and headache on four separate occasions after ibuprofen ingestion. One such episode was accompanied by cerebrospinal fluid findings compatible with meningitis. Drug rechallenge under controlled conditions established the relationship between ibuprofen ingestion and meningitis. (<i>JAMA</i>239:1062-1064, 1978)
Vaginal absorption of povidone-iodine
Authors: H. Vorherr
Journal: JAMA (1980)

In 12 nonpregnant women, total iodine, protein-bound iodine, inorganic iodine, and thyroxine values were measured in serum before and 15, 30, 45, or 60 minutes after a two-minute vaginal disinfection with povidone-iodine (Betadine). Only 15 minutes after application, serum iodine levels were raised and remained significantly elevated 30, 45, and 60 minutes after disinfection. Serum concentrations of total iodine and inorganic iodine were increased up to fivefold to 15-fold, respectively; during the relative short period of observation, thyroxine levels were not altered. An overload of iodine can suppress thyroid hormonogenesis, and the fetal and neonatal thyroid glands are especially sensitive. In pregnant women, vaginitis should not be treated with povidone-iodine because of the possible development of iodine-induced goiter and hypothyroidism in the fetus and newborn. The risk is especially high when povidone-iodine is used repeatedly. (<i>JAMA</i>1980;244:2628-2629)
Health Effects of Indoor Fluoride Pollution from Coal Burning in China
Authors: Mitsuru Ando, Mihoko Tadano, Shinji Asanuma, Kenji Tamura, Shousui Matsushima, Toshikazu Watanabe, Takeshi Kondo, Shiro Sakurai, Rongdi Ji, Chaoke Liang, Shouren Cao
Journal: Environmental Health Perspectives (1998)

The combustion of high fluoride-content coal as an energy resource for heating, cooking, and food drying is a major exhaust emission source of suspended particulate matter and fluoride. High concentrations of these pollutants have been observed in indoor air of coal-burning families in some rural areas in China. Because airborne fluoride has serious toxicological properties, fluoride pollution in indoor air and the prevalence of fluorosis have been analyzed in a fluorosis area and a healthy nonfluorosis area in China and in a rural area in Japan. For human health, fluoride in indoor air has not only been directly inhaled by residents but also has been absorbed in stored food such as corn, chilies, and potatoes. In the fluorosis area in China, concentrations of urinary fluoride in the residents have been much higher than in the nonfluorosis area in China and in the rural area in Japan. In the fluorosis area, almost all elementary and junior high school students 10-15 years of age had dental fluorosis. Osteosclerosis in the skeletal fluorosis patients was very serious. Urinary deoxypyridinoline in rural residents in China was much higher than in rural residents in Japan. Data suggest that bone resorption was extremely stimulated in the residents in China and that fluoride may stimulate both bone resorption and bone formation. Because indoor fluoride from combustion of coal is easily absorbed in stored food and because food consumption is a main source of fluoride exposure, it is necessary to reduce airborne fluoride and food contamination to prevent serious fluorosis in China.
Acute pancreatitis
Authors: Andrew Kingsnorth, Derek O'Reilly
Journal: BMJ (2006)

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Neuro and hepatic inflammation and steatosis are modulated by gut microbial changes after isolated hepatic vagotomy and antibiotics in cirrhosis
Authors: Yuan Zhang, Derrick Zhao, Jun-Kai Yan, Yanyan Wang, Yunling Tai, Jason Kang, Siddhartha Ghosh, Masoumeh Sikaroodi, Phillip Hylemon, Patrick Gillevet, Huiping Zhou, Jasmohan S Bajaj
Journal: Journal of Hepatology (2020)
Failure of Extracranial–Intracranial Arterial Bypass to Reduce the Risk of Ischemic Stroke
Journal: New England Journal of Medicine (1985)

To determine whether bypass surgery would benefit patients with symptomatic atherosclerotic disease of the internal carotid artery, we studied 1377 patients with recent hemisphere strokes, retinal infarction, or transient ischemic attacks who had atherosclerotic narrowing or occlusion of the ipsilateral internal carotid or middle cerebral artery. Of these, 714 were randomly assigned to the best medical care, and 663 to the same regimen with the addition of bypass surgery joining the superficial temporal artery and the middle cerebral artery. The patients were followed for an average of 55.8 months. Thirty-day surgical mortality and major stroke morbidity rates were 0.6 and 2.5 per cent, respectively. The postoperative bypass patency rate was 96 per cent. Nonfatal and fatal stroke occurred both more frequently and earlier in the patients operated on. Secondary survival analyses comparing the two groups for major strokes and all deaths, for all strokes and all deaths, and for ipsilateral ischemic strokes demonstrated a similar lack of benefit from surgery. Separate analyses in patients with different angiographic lesions did not identify a subgroup with any benefit from surgery. Two important subgroups of patients fared substantially worse in the surgical group: those with severe middle-cerebral-artery stenosis (n = 109, MantelHaenszel chi-square = 4.74), and those with persistence of ischemic symptoms after an internal-carotid-artery occlusion had been demonstrated (n = 287, chi-square = 4.04). This study thus failed to confirm the hypothesis that extracranial—intracranial anastomosis is effective in preventing cerebral ischemia in patients with atherosclerotic arterial disease in the carotid and middle cerebral arteries. (N Engl J Med 1985; 313:1191–1200.)
Gastrointestinal Polyposis with Mucocutaneous Pigmentation (Peutz–Jeghers Syndrome)
Authors: Thomas L. Dormandy
Journal: New England Journal of Medicine (1957)

DiscussionThe Peutz–Jeghers syndrome has three cardinal features: gastrointestinal polyposis, mucocutaneous pigmentation and inheritance through a mendelian-dominant gene.Gastrointestinal Polyposis Historical. Though Peutz,1 in 1921, was the first to recognize the familial association of gastrointestinal polyposis and mucocutaneous pigmentation31 cases of gastrointestinal and in particular small-intestine polyposis had been described before him. The fact that more cases of gastrointestinal polyposis are recorded today with the characteristic pigmentation than without suggests that some of these patients may have had the complete syndrome, the pigmentation not having been noticed or its significance not having been appreciated.13,69 Skifasowski74 gave what may be . . .
Radiologic Maxims.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pharyngeal Stimulation in Treatment of Arrhythmias
Authors: Samuel Johnson
Journal: JAMA (1968)

<h3>To the Editor:—</h3> In a recent article by Salem et al,<sup>1</sup>a new technique for the treatment of hiccups was described. I have been working closely with Dr. Salem in the last few years and have been impressed by the efficiency of his technique of pharyngeal stimulation in the treatment of hiccups. Moreover, I have been able to treat a variety of supraventricular arrhythmias with the same method. The usefulness of this technique was first noted during suctioning the pharynx to remove secretions prior to induction of anesthesia for cardioversion. The preexisting supraventricular tachycardia converted to a normal sinus rhythm. This, coupled with the effectiveness of pharyngeal stimulation in the treatment of hiccups, led me to investigate its use in the treatment of arrhythmias, mainly of reflex origin, during anesthesia. The arrhythmias treated consisted of two cases of paroxismal atrial tachycardia, two cases with premature ventricular contractions, three cases
The Resource-Based Relative Value Scale. Toward the development of an alternative physician payment system
Authors: W. C. Hsiao
Journal: JAMA (1987)

This article describes the design and methods of a study currently under way to develop a Resource-Based Relative Value Scale (RBRVS); an alternative basis for establishing the payment rate for the services and procedures (S/Ps) of physicians in medical and surgical specialties. Physician resource inputs to be measured include (1) S/P time, (2) pre-S/P and post-S/P times, (3) intensity, (4) practice costs, including malpractice premiums, and (5) the cost of specialty training. These five factors will be combined to produce an RBRVS denominated in nonmonetary units. In the initial phase of the study, data on time and intensity will be obtained through a national survey of physicians who perform these S/Ps. In the second, consensus phase of the project, the investigators will convene a panel of representatives of the medical profession, third-party payers, consumers, and other interested parties to examine areas of agreement and disagreement as to how an RBRVS should be used for policy purposes. The final results of this study are expected by the summer of 1988. (<i>JAMA</i>1987;258:799-802)
Abstract 930: NADPH Oxidase 2 is Responsible for α1-Adrenergic Receptor-Dependent Reactive Oxygen Species Production in Adult Rat Ventricular Myocytes
Authors: Steve Lancel, Ellen O Weinberg, Eugene B Valsky, Mark Y Jeong, Zareen Farukhi, David R Pimentel, Kalyankar Mahadev, Barry J Goldstein, Patrick J Pagano, Deborah A Siwik, Wilson S Colucci
Journal: Circulation (2007)

Background: Five NAPDH oxidase (NOX) isoforms have been implicated in reactive oxygen species (ROS) generation in a cell type- and agonist-specific manner. We previously showed that α 1 -adrenoreceptor (α 1 -AR) stimulation in cultured adult rat ventricular myocytes (ARVM) leads to NADPH-dependent ROS-production, suggesting that a NOX may be responsible. The goal of this project was to determine whether NOX mediates α 1 -AR-stimulated ROS production in ARVM, and if so, which isoform(s) is responsible. Methods and Results: ROS production, assessed by dichlorofluoresceine (DCF) fluorescence, was increased by 51±7 % in ARVM subjected to α 1 -AR stimulation (norepinephrine 1μM + propranolol 2 μM; 30 min; p=0.002, n=3/group). Apocynin (Apo, 50 μM), a broad-spectrum NOX inhibitor, prevented α1-AR-mediated ROS generation (+19±8% vs Apo-treated/α 1 -AR-unstimulated cells, n=4, NS), suggesting a role for NOX. Expression of NOX1, 2 and 4, as well as regulatory proteins p22 phox , p47 phox , Rac1 and Rac2, but not NOX3, was detected by RT-PCR in ARVM. Neither the inhibitory Nox4-tat peptide (+56±7% vs NOX4-tat-treated/α 1 -AR-unstimulated cells) nor adenovirus-mediated overexpression of NOX4 dominant-negative protein (+84±17% vs NOX4DN-infected/α 1 -AR-unstimulated cells) reduced α 1 -AR-induced DCF fluorescence increase (n=4/ group, both p&lt;0.01 vs α 1 -AR-unstimulated cells). In contrast, adenovirus-mediated overexpression of dominant negative p47 phox , p67 phox and Rac1 proteins prevented α 1 -AR-mediated ROS production, suggesting that the responsible NOX requires each of these proteins. NOX2-tat inhibitory peptide (+18.4±7.3% vs NOX2-tat-treated/α 1 -AR-unstimulated cells, n=6, NS), but not NOX1-tat inhibitory peptide (+51±8% vs NOX1-tat-treated/α 1 -AR-unstimulated cells, n=3, p&lt;0.01), prevented α 1 -AR-mediated ROS production. Conclusion: The NOX2 complex, including the catalytic subunit gp91 phox , and the regulatory proteins p47 phox , p67 phox and Rac1, is directly responsible for α 1 -adrenergic-receptor induced ROS production in adult rat ventricular myocytes.
Society Proceedings
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Induction of early-immediate genes by tumor necrosis factor α contribute to liver repair following chemical-induced hepatotoxicity
Authors: A Bruccoleri
Journal: Hepatology (1997)

We and others have shown that tumor necrosis factor α (TNF-α) expression is increased in the livers of experimental animals following exposure to the chemical hepatotoxin, carbon tetrachloride (CCl4). Because TNF-α is involved in mediating inflammatory responses, its elevated expression is presumed to be associated with potentiating hepatotoxicity and/or aiding in liver repair processes. To study the role of TNF-α in chemical-induced hepatotoxicity, mice were administered neutralizing antibodies to TNF-α before administration of low, but hepatotoxic, doses of CCl4. Antibody treatment prevented CCl4-mediated increases in early-immediate gene expression associated with liver regeneration, including expression of c-jun and c-fos proto- oncogenes, as well as DNA binding of the activator protein-1 (AP-1) nuclear transcription factor. Hepatocyte proliferation following CCl4 treatment was also reduced in anti-TNF-α antibody-treated mice, as evidenced by a lack of proliferating cell nuclear antigen (PCNA) staining. Antibody treatment slightly delayed liver repair processes, as evidenced by extending the period in which plasma liver enzyme levels were increased and hepatocellular necrosis could be observed. Consistent with the above observations, injection of recombinant TNF-α into control mice induced rapid expression of c-jun and c-fos proto-oncogenes. Taken together, these results indicate that TNF-α positively modulates liver recovery following CCl4 exposure presumably by stimulating early-immediate genes involved in hepatic mitogenesis, a phenomenon also observed following partial hepatectomy.
SURGICAL SHOCK.
Authors: FENTON B. TURCK
Journal: JAMA (1897)

The experiments on animals for inducing shock were reported before theAmerican Medical Association, May, 1896. In these experiments the color changes in the abdominal viscera were noted, the blood pressure in both arteries and veins in the peripheral circulation as well as the central. I will give a brief résumé of some of these experiments. Experiment No. 1 showed that after exposure of the stomach and intestines to draught of air from an open window, temperature 58, profound shock resulted. The gastric veins within half an hour were all congested. Respiration shallow; pulsations weak. The chloroform was pushed to the extreme; animals stopped breathing. Withdrawal of chloroform and artificial respiration did not excite respiratory movements. The intragastric resuscitator<sup>1</sup>was introduced into the stomach, and hot water 130 F. As soon as the water returned from the other side of the double tube, and more hot water introduced the animal
Biliary and pancreas posters 198-208
Authors: S Parry, J Barton, M Welfare, I Mohammed, L Cherkas, S Riley, T Spector, N Trudgill, S Lal, J Mclaughlin, G Giampaolo, G Dockray, A Varro, D Thompson, J Jones, D Kendall, P Millns, C Hawkey, S Dunlop, D Jenkins, R Spiller, L Gregory, L Yaguez, S Coen, E Amaro, S Smale, A Hobson, S Williams, Q Aziz, V Chudleigh, E Brennan, S Tarry, S Myers, S Lewis, G Smith, K Palmer
Journal: Gut (2002)

Introduction: Previous studies, many uncontrolled, suggest 4 to 32% of people develop irritable bowel syndrome (IBS) after ID.Little information is available on the development of other FGIDs after ID.Aim: To determine if patients with stool culture confirmed bacterial diarrhoea were more likely to develop gut symptoms consistent with a diagnosis of IBS, functional dyspepsia or functional diarrhoea at 3 and 6 month follow up compared with community controls.Methods: A prospective community-based case-control study over one year.Subjects with stool positive bacterial infectious diarrhoea and control subjects from the same primary care practice were invited to participate.The presence or not of IBS, functional dyspepsia or functional diarrhoea was diagnosed at the start and at follow up using self-complete Rome II modular questionnaires.The diagnosis of a baseline FGID excluded subjects from continuing.There were 128 cases and 219 community controls eligible and who consented to participate.Results: At follow up there was a higher incidence of FGIDs in the cases compared with controls, mainly due to a higher incidence of IBS (see table ).There was no difference in the incidence of functional dyspepsia between cases and controls.Conclusions: IBS and functional diarrhoea is diagnosed more frequently in people at three and six-month follow up after an episode of stool positive bacterial diarrhoea compared with community controls despite careful exclusion of people with pre-existing FGIDS and adds further support for the concept of post-infectious IBS.
DNA Synthesis as a Marker in Fractionated Radiation Therapy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inflammatory bowel disease posters 258-298
Authors: S Parry, J Barton, M Welfare, I Mohammed, L Cherkas, S Riley, T Spector, N Trudgill, S Lal, J Mclaughlin, G Giampaolo, G Dockray, A Varro, D Thompson, J Jones, D Kendall, P Millns, C Hawkey, S Dunlop, D Jenkins, R Spiller, L Gregory, L Yaguez, S Coen, E Amaro, S Smale, A Hobson, S Williams, Q Aziz, V Chudleigh, E Brennan, S Tarry, S Myers, S Lewis, G Smith, K Palmer, Z Khan, E Simpson, A Cole, I Macdonald, D Pye, A Austin, J Freeman
Journal: Gut (2002)

Introduction: Previous studies, many uncontrolled, suggest 4 to 32% of people develop irritable bowel syndrome (IBS) after ID.Little information is available on the development of other FGIDs after ID.Aim: To determine if patients with stool culture confirmed bacterial diarrhoea were more likely to develop gut symptoms consistent with a diagnosis of IBS, functional dyspepsia or functional diarrhoea at 3 and 6 month follow up compared with community controls.Methods: A prospective community-based case-control study over one year.Subjects with stool positive bacterial infectious diarrhoea and control subjects from the same primary care practice were invited to participate.The presence or not of IBS, functional dyspepsia or functional diarrhoea was diagnosed at the start and at follow up using self-complete Rome II modular questionnaires.The diagnosis of a baseline FGID excluded subjects from continuing.There were 128 cases and 219 community controls eligible and who consented to participate.Results: At follow up there was a higher incidence of FGIDs in the cases compared with controls, mainly due to a higher incidence of IBS (see table ).There was no difference in the incidence of functional dyspepsia between cases and controls.Conclusions: IBS and functional diarrhoea is diagnosed more frequently in people at three and six-month follow up after an episode of stool positive bacterial diarrhoea compared with community controls despite careful exclusion of people with pre-existing FGIDS and adds further support for the concept of post-infectious IBS.