tbuckley/cabot-search huggingface dataset:
Controversial Costs of Cocaine
Authors: David Page
Journal: JAMA (1992)

<h3>To the Editor.</h3> —In the article by Phibbs et al,<sup>1</sup>"The Neonatal Costs of Maternal Cocaine Use," the abstract did not adequately reflect the results presented in the article. In the results section of the abstract, the authors state that the cost of neonatal care until medically cleared for discharge was significantly higher for cocaine-exposed than for non-cocaine-exposed infants. This leaves the reader to assume that cocaine exposure is the factor that explains the impressive difference. However, the two populations compared in the study (cocaine-exposed and non-cocaine-exposed) differed in several important ways. These included use of other substances, adequacy of prenatal care, smoking, racial composition, age, and gravidity of mothers. Each of these variables could be important confounders and (as the authors rightly demonstrated) should be controlled in drawing conclusions as to the effect of the cocaine exposure itself. In the body of the text the authors are
Posters
Authors: S Muthiah, S Polubothu, A Husain, T Oliphant, V Kinsler, N Rajan
Journal: British Journal of Dermatology (2020)

Large congenital melanocytic naevi (CMN) arise mainly due to postzygotic mutations in NRAS, and are of clinical importance owing to their increased risk of malignant transformation.Recently, a subtype of large CMN has been characterized, termed spilus-type CMN, and is identified by the presence of a large caf e-au-lait background patch and superimposed macular or papular darker pigmented lesions.We present a patient who developed multiple melanomas within a spilus-type CMN affecting the entire left leg where a pathogenic variant in MAP2K1 was found, hitherto unreported in this entity.A 43year-old woman presented with a superficial spreading malignant melanoma (SSMM) on the left medial thigh [Breslow thickness (BT) 0.6 mm], arising within a spilus-type CMN.Two further melanomas were identified within the spilus-type CMN, arising on the left lateral foot and left lateral thigh, and reported as lentiginous malignant melanoma (LMM; BT 0.3 mm) and a LMM with complete regression of the dermal component, respectively.Using a targeted next-generation sequencing approach, a missense substitution in MAP2K1 (c.607G>A, p.E203K) was identified within two melanomas (medial left thigh and left lateral foot) and the background spilus-type CMN.Pathogenetic variant allele loads were 2% in the LMM, 7% in the SSMM and 1% in the CMN (read depth >10009).A second variant in MAP2K1 (c.308T>A, p.l103N) was seen in the SSMM (7% allele load) but undetectable in the other melanoma and CMN.Targeted sequencing did not detect activating HRAS or NRAS mutations in the spilus-type CMN, nor melanomas.Spilus-type CMN are a clinically heterogeneous entity, and our finding of a postzygotic mutation in MAP2K1 adds to known existing drivers such as NRAS.The MAP2K1 E203K variant lies within the protein kinase domain of the MAP2K1 protein, and results in a gain of function at the protein level.Similar gain-of-function mutations in the germline give rise to cardiofaciocutaneous syndrome, which has been associated with high numbers of melanocytic naevi, adding support to the pathogenicity of this variant.Furthermore, MAP2K1 mutations have been found in up to 6% of cases in series of melanoma.Taken together, our findings suggest that our patient's spilus-type CMN is driven by a postzygotic mutation in MAP2K1, predisposing to development of melanoma within the lesion.
Enteric Fever in India, and in Other Tropical and Sub-Tropical Regions. A Study in Epidemiology and Military Hygiene.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Environment
Authors: Joachim F. Wohlwill
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgical treatment of hydatid cyst of the lung: review of 30 cases
Authors: I Yalcinkaya, M. Er, B. Ozbay, S. Ugras
Journal: European Respiratory Journal (1999)

Hydatid cyst disease is still a problem in Turkey, especially in the east Anatolian region, as well as in many other places in the world. A retrospective review was made of the surgical treatment of 30 patients with pulmonary hydatid cysts during the last 3 yrs. Nineteen patients were male and 11 female with an average age of 23.5 yrs (range 4-44 yrs). Cystotomy and capitonnage were performed in 28 of the 30 cases (93.4%). The transdiaphragmatic route or simultaneous laparotomy was preferred when the liver was involved. Albendazole was used in four patients with multiple hydatid cyst due to probable recurrence in the postoperative period. Cough and chest pain were the prominent symptoms in the majority of cases. A single lobe was affected in 22 patients. Unilateral multiple foci were present in four patients and bilateral multiple foci in four. Six patients had concomitant liver cysts. Morbidity was low and no mortality was seen. No recurrences were seen on control chest radiographs during the last 2-yr follow-up. In the treatment of hydatid cyst of the lung, conservative surgical methods such as cystotomy and capitonnage still remain the treatment of choice. Medical treatment could be used for prophylactic purposes and in some instances, but the percutaneous aspiration method should not be performed.
WORK OF THE ANTI-VACCINISTS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BACTERIOLOGICAL RESEARCHES.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Author Affiliation
Authors: Song Kim, Rohit Bhoil
Journal: JAMA Internal Medicine (2015)

Elizabeth A. Regan, MD; David A. Lynch, MD; Douglas Curran-Everett, PhD; Jeffrey L. Curtis, MD; John H. M. Austin, MD; Philippe A. Grenier, MD; Hans-Ulrich Kauczor, MD; William C. Bailey, MD; Dawn L. DeMeo, MD; Richard H. Casaburi, PhD, MD; Paul Friedman, MD; Edwin J. R. Van Beek, MD; John E. Hokanson, PhD; Russell P. Bowler, MD; Terri H. Beaty, PhD; George R. Washko, MD; MeiLan K. Han, MD; Victor Kim, MD; Song Soo Kim, MD; Kunihiro Yagihashi, MD; Lacey Washington, MD; Charlene E. McEvoy, MD; Clint Tanner, MD; David M. Mannino, MD; Barry J. Make, MD; Edwin K. Silverman, MD; James D. Crapo, MD; for the Genetic Epidemiology of COPD (COPDGene) Investigators
L-m-tyrosine and Parkinsonism
Authors: G. C. Cotzias
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Administrations of levodopa, which generates the primary catecholamine dopamine, or of the tertiary catecholamine apomorphine hydrochloride, have improved the symptoms of parkinsonism.<sup>1,2</sup>L-<i>m</i>-tyrosine generates the primary amine<i>m</i>-tyramine, which does not have a catechol configuration, not even an equivalent one. In experimental animals, however, L-<i>m</i>-tyrosine had induced manifestations similar to those induced by levodopa, which differed somewhat from those of apomorphine.<sup>3,4</sup>L-<i>m</i>-tyrosine was, therefore, proposed for the treatment of parkinsonism. These considerations produced two reasons for testing the effects of L-<i>m</i>-tyrosine on the symptoms of parkinsonism: (1) to determine whether or not the catechol moiety is necessary for the therapeutic actions of amines in this disease, and (2) to determine whether or not reactions of animals to a new drug can be extrapolated into therapy on the basis of their being similar to those of an
The determinants of vena contracta and its value in evaluating severity of aortic regurgitation Mehmet Eren, Bahadir Dagdeviren, Osman Bolca, Abdurrahman Eksik, Yekta Gurlertop, Tuna Tezel. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey
Journal: Journal of the American College of Cardiology (2001)
THE RELATIVE REACTION WITHIN LIVING MAMMALIAN TISSUES
Authors: Peyton Rous
Journal: The Journal of Experimental Medicine (1925)

Mice can be vitally stained with many of the phthalein indicators. The staining is diffuse, appearing to interfere not at all with health in the case of the majority of the dyes. The color phenomena show that these retain the character of indicators. A special technique has been evolved for the determination of the hues of the various organs, which are readily modified by extraneous influences. The ability to recognize that the pH has thus been altered is a signal advantage of the indicator method. Phthaleins of slightly alkaline range or one that trenches slightly on acidity have been employed for the work here reported. Cresol red, phenol red, and brom phenol red have proved especially useful. The observations with the three agree closely in pointing to the existence of notable differences between the reaction of the blood and that within the tissues generally. The hue of blood plasma from the right heart is such as to suggest that its reaction lies at about pH 7.38 ordinarily, whereas that of the most alkaline of the tissues, judging from its color, the connective tissue, would appear to have a pH of 7.2 or slightly less. The tendons seem to be nearly but not quite so alkaline. The other stained tissues without exception, are of a hue which would indicate that the reaction lies beyond the range of phenol red on the acid side, that is to say is at least as acid as pH 6.6. In a subsequent paper observations which accord with these findings, carried out with indicators of frankly acid range, will be described. On the exposure of tissues to air, without disturbance of the circulation, some of them become alkaline. In the case of connective tissue, at least, the change is a consequence of the escape of carbon dioxide. The gas passes readily in and out, exerting a practically immediate influence on the color of the tissue bared by eversion of a skin flap; and so much may be absorbed on exposure to pure carbon dioxide, when the surface is large, that a general acidosis results. The precise interpretation of the color changes in terms of pH waits necessarily upon further work.
Letter: Smokers wrinkles
Authors: William Weiss
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In 1971 Daniell<sup>1</sup>reported a relationship between "crow's feet" wrinkles and smoking in a large population of which more than 98% was white. Allen et al (225:1067, 1973) concluded that wrinkles in the crow's foot area are caused by actinic exposure and not by smoking, because black patients had no such wrinkles whether they smoked or not and also because histologic sections of skin in white patients showed changes only of actinic elastosis, whether they smoked or not. I believe this conclusion is not warranted by the data presented. It may be true that blacks do not develop wrinkles, but this does not refute a relationship between smoking and wrinkles in whites. And even if it were uncontrovertible that histologic abnormalities of elastosis were caused by actinic exposure, this does not eliminate smoking as an important factor that determines who wrinkles in response to sunlight. Their concept
Painless thyroiditis and transient thyrotoxicosis after Graves' disease
Authors: J. H. Check
Journal: JAMA (1980)

PAINLESS thyroiditis associated with transient thyrotoxicosis is a well-recognized entity and may account for 15% of all cases of thyrotoxicosis.<sup>1,2</sup>It is important to distinguish this condition from Graves' disease, because treatment of the two disorders is different. Because the uptake of iodine is depressed in transient thyrotoxicosis associated with thyroiditis, therapy with antithyroid medication or iodine 131 is ineffective, and since the disease is selflimited, surgery is inappropriate.<sup>3</sup>Therefore, a radioactive iodine uptake study in newly discovered thyrotoxic patients is indicated as a means of distinguishing these two different conditions.<sup>4,5</sup> Graves' disease is characterized by remissions and exacerbations. However, in a patient experiencing an apparent recurrence, the radioactive iodine uptake determination should be repeated, even if the serum thyroxine (T<sub>4</sub>) or triiodothyroxine (T<sub>3</sub>) level is elevated, as our case illustrates. <h3>Report of a Case</h3> The condition of a 28-year-old patient was first diagnosed as
Clinical and Radiological Features of Spontaneous Internal Biliary Fistulas
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vegetarians and Healing
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Necrotizing Ulcers of the Penis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shadows of Futurity
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal