tbuckley/cabot-search huggingface dataset:
Practical Neuroangiography
Authors: Ian B. Ross
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intravenous Trypsin
Authors: ALEXANDER TAYLOR, IRVING S. WRIGHT
Journal: Circulation (1954)

Studies were carried out regarding the effect of intravenous trypsin on rabbits. These included investigations into the toxicity and the tendency for the production of intravascular coagulation. The effect on artificial preformed thrombi was also observed. It was found that in the doses used, the intravenous administration of trypsin was not efficacious in the treatment of intravascular thrombosis. These studies failed to provide evidence to justify its use as a therapeutic agent in man.
Lister's Method.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of thiazides and amiloride in treatment of moderate hypertension
Authors: J P Thomas, W H Thomson
Journal: BMJ (1983)

The biochemical disturbance produced by thiazide diuretics and by amiloride during treatment of moderate hypertension were compared.Two parallel studies were initiated.In one 40 patients with newly diagnosed hypertension were treated with metoprolol and a diuretic, either hydrochlorothiazide or amiloride.In a second study 38 patients receiving longstanding treatment with hypotensives and thiazides either continued the treatment or replaced the thiazide with amiloride.Initial biochemi- cal assessments were compared with those after two years in the study.In previously untreated patients, thiazide produced a significant fall in plasma potassium and hyperuricaemia that did not occur with amiloride (p < 0-001).Those patients receiving long term treatment for their hypertension who continued to take thiazides had persistent hypokalaemia and hyperuricaemia.Substitution with amiloride corrected the hypokalaemia and serum uric acid returned toward normal ranges, but this change was not statistically significant.Patients receiving long term treatment also had impaired glucose tolerance, this remained unchanged in those receiving thiazide but was corrected in those receiving amiloride.Compared with amiloride thiazides produced undesir- able but reversible biochemical changes.As control of hypertension was equally effective with both preparations, we suggest that a combination of amiloride with a beta blocker in treatment of moderate hypertension is preferred.
Doctors and Doctors, Wise and Otherwise: On the Firing Line Fifty Years
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elemental Modifications and Polycyclic Aromatic Hydrocarbon Metabolism in Human Fibroblasts
Authors: R. W. Hart, F. B. Daniel, O. R. Kindig, C. A. Beach, L. B. Joseph, R. C. Wells
Journal: Environmental Health Perspectives (1980)

Mineral fibers and particulates represent one of the best documented, economically important, and ubiquitously occurring categories of human carcinogens. Yet, while a wealth of information exists concerning the mechanism of action of physical, chemical, and viral carcinogens, virtually nothing is known relative to the mechanism of action of this economically important class of carcinogenic compounds known as mineral fibers and particulates. While the length and diameter of various forms of asbestos have been associated with both cellular toxicity in vitro and tumor occurrence in vivo, nothing is known about whether or not these same physical properties are responsible for the purported synergistic interaction between cigarette smoking and asbestos exposure relative to the induction of bronchogenic carcinoma. Thus, while the risk of bronchogenic carcinoma for nonsmokers exposed to asbestos appears to be only slightly greater than that for unexposed nonsmoking populations, the risk of occurrence of this same tumor in asbestos workers who also smoke is approximately 100-fold greater than in nonsmoking asbestos workers. The risk of bronchogenic carcinoma is increased approximately 8-fold in asbestos workers who smoke over non-exposed smokers. Since it is clear that cigarette smoke contains over 150 polycyclic aromatic hydrocarbons, some of which are known animal carcinogens, and since other laboratories have reported that metals associated with asbestos redirect the metabolism of these agents, it was of interest to us to investigate the effects of mineral fibers on the metabolism and biochemistry of polycyclic aromatic hydrocarbons.
Monitoring of Human Populations at Risk by Different Cytogenetic End Points
Authors: Wagida A. Anwar
Journal: Environmental Health Perspectives (1994)

Humans are exposed to a large number of environmental genotoxic agents.These can increase the probability that somatic mutation will occur.The use of genotoxicity testing is essential for assessment of potential human toxicity so that hazards can be prevented.Cytogenetic monitoring of human populations exposed to chemicals has proved to be a useful tool for detecting the chemical mutagenic effects.Cytogenetic analysis of human chromosomes in peripheral lymphocytes allows direct detection of mutation in somatic cells.Cytogenetic monitoring of a group of traffic policemen from Cairo, Egypt, was an example of a human population study.The induction of chromosomal damage was studied in a group of 28 traffic policemen with exposure of over 10 years and a control group of 15 policemen trainers.Blood lead level was significantly higher in the traffic policemen (30 ± 8.7) unit compared to the control group (18.2 ± 1.2) unit.The percentage of chromosomal aberrations (7.7 ± 3.1), as well as the mean sister chromatid exchanges (7.5 ± 3.4), were significantly higher among the traffic policemen than in the control group.The percentage of chromosomal aberrations was 2.8 ± 2.1 and the mean sister chromatid exchanges was 4.8 ± 2.9 in the control group.On the other hand, the increase in chromosome damage among the traffic policemen was enhanced further by smoking.
The Architecture of Normal and Malformed Hearts: A Phylogenetic Theory of Their Development
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P171: Vitamin D and Cardiometabolic Risk Factors: The Jerusalem Perinatal Study
Authors: Amy Moore, Hagit Hochner, Colleen Sitlani, Michelle A Williams, David S Siscovick, Yechiel Friedlander, Daniel A Enquobahrie
Journal: Circulation (2012)

Background: Vitamin D, a pleotropic hormone, influences cellular and tissue functions that are potentially related to cardiometabolic risk. Vitamin D deficiency and insufficiency have also been related to cardiovascular diseases. However, relationships between vitamin D and cardiometabolic risk factors in young adults are not well-characterized. Methods: We examined associations of vitamin D with cardiometabolic risk factors among a subset of the Jerusalem Perinatal Study (JPS) population, a birth cohort of Jerusalem residents born between 1974 and 1976. Offsprings aged 30-35 years, sampled based on maternal pre-pregnancy body mass index (BMI) and offspring birth weight, and their mothers were recruited as part of the JPS-1 study. Data were collected using interviews and field physical examinations. Fasting blood specimens were obtained for vitamin D and biomarker (glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) measurements. We used liquid chromatography-tandem mass spectroscopy to measure total vitamin D (25-[OH] D). Sample-weighted multiple regression models, adjusted for potential confounders, were used to examine associations, and determine coefficients and 95% confidence intervals. Results: Mean total vitamin D levels were 22.27ng/ml, 23.48ng/ml and 21.03ng/ml among all study participants, males (N=617) and females (N=588), respectively. Vitamin D levels were statistically different between males and females (p-value &lt;0.001). Current smokers had higher vitamin D levels compared with non-smokers, even after adjustment for current BMI, ethnicity, occupation and other potential confounders (β=1.41, p-value= 0.039). Overall, higher vitamin D levels were associated with lower BMI (p-values 0.002) and lower diastolic blood pressure (p-values 0.011). Conclusion: Vitamin D is associated with cardiometabolic risk factors in young adults. The unexpected association between current smoking and higher vitamin D in our study needs replication and further investigation.
Patient satisfaction among elderly enrollees and disenrollees in Medicare health maintenance organizations. Results from the National Medicare Competition Evaluation
Authors: L. F. Rossiter
Journal: JAMA (1989)

More than 1 million Medicare beneficiaries have enrolled in health maintenance organizations (HMOs) and competitive medical plans under a new program in which beneficiaries can freely enroll in a risk-based HMO in their area or remain in the fee-for-service sector under Medicare. Based on a randomly selected nationwide sample of beneficiaries, we analyzed differences in patient satisfaction between 2091 beneficiaries who were continuously enrolled in an HMO plan for 1 year and 1000 beneficiaries in the fee-for-service sector. We also studied the reasons for disenrollment. No significant difference in overall satisfaction was found between HMO enrollees and fee-for-service beneficiaries. However, HMO enrollees expressed less satisfaction compared with fee-for-service beneficiaries regarding the professional competence of their health care providers and the willingness of the HMO staff to discuss problems. On the other hand, HMO enrollees were more satisfied than fee-for-service beneficiaries with waiting times and claims processing. Approximately half of the disenrollment from an HMO within 1 year was attributed to misunderstanding the terms of enrollment. (<i>JAMA</i>. 1989;262:57-63)
Is cocaine a sympathetic stimulant during general anesthesia?
Authors: P. G. Barash
Journal: JAMA (1980)

Eighteen patients undergoing coronary artery surgery were observed to examine whether cocaine in a clinically used dose exerts sympathomimetic effects during general anesthesia. Eleven patients received cocaine hydrochloride as a 10% solution (1.5 mg/kg) applied topically to the nasal mucosa before nasotracheal intubation. Seven patients had a similar procedure without cocaine. Blood pressure, pulse rate, cardiac index, left ventricular stroke work index, total peripheral vascular resistance, and pulmonary vascular resistance were measured. There were no important differences in cardiovascular function between patient groups. The rapid rise in plasma cocaine concentration, reaching 331 ng/mL at 30 minutes and 320 ng/mL at 45 minutes, bore no apparent relationship to any changes in cardiovascular function. We conclude that under conditions of this study, administration of topical cocaine does not exert any clinically significant sympathomimetic effect and appears to be well tolerated in anesthetized patients with coronary artery disease. (<i>JAMA</i>243:1437-1439, 1980)
The Lazarus phenomenon
Authors: V. Adhiyaman, S. Adhiyaman, R. Sundaram
Journal: Journal of the Royal Society of Medicine (2007)

Even though Lazarus phenomenon is rare, it is probably under reported. There is no doubt that Lazarus phenomenon is a reality but so far the scientific explanations have been inadequate. So far the only plausible explanation at least in some cases is auto-PEEP and impaired venous return. In patients with PEA or asystole, dynamic hyperinflation should considered as a cause and a short period of apnoea (30–60 seconds) should be tried before stopping resuscitation. Since ROSC occurred within 10 minutes in most cases, patients should be passively monitored for at least 10 minutes after the cessation of CPR before confirming death.
Diagnostik und Therapie der Kinderkrankheiten, mit speziellen Arzneiverordnungen für das Kindesalter: Ein Wegweiser für den praktischen Arzt.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhaled Crocidolite Mutagenicity in Lung DNA
Authors: Bertrand Rihn, Catherine Coulais, Edmond Kauffer, Marie-Claire Bottin, Patrick Martin, Francois Yvon, Jean Claude Vigneron, Stephane Binet, Nathalie Monhoven, Guy Steiblen, Gerard Keith
Journal: Environmental Health Perspectives (2000)

We used transgenic mice carrying the lacI reporter gene to study the mutagenesis potential of asbestos crocidolite. The animals were exposed by nose-only inhalation to an aerosol containing 5.75 mg/m(3) crocidolite dust for 6 hr/day and 5 consecutive days. After 1, 4, and 12 weeks, we examined four end points: the cytology of bronchoalveolar lavage, the lung load of crocidolite, the hydrophobic DNA adducts, and the mutations in the lacI reporter gene. Twelve weeks after exposure, nearly 10% of the inhaled fibers remained in the lung (227 +/- 103 ng/mg lung). There was evidence of a typical inflammatory response consisting of multinucleate macrophages at weeks 4 and 12, whereas immediately after the exposure, we observed numerous polymorphonuclear neutrophils. The mutant frequency significatively increased during the fourth week after the exposure: 13.5 [time] 10(-5) in the exposed group versus 6. 9 10(-5) in the control group. The induction factor, defined by the ratio of checked mutants of exposed mice to checked mutants of control mice, was 1.96. The mutation spectrum of control lung DNA and exposed lung DNA was similar, suggesting the possible involvement of a DNA repair decrease in crocidolite-treated animals. We used the (32)P-postlabeling method and did not detect any increase of either 5 mC or bulky adduct in treated mice. This is the first study that demonstrates asbestos mutagenicity in vivo after a nose-only inhalation.
DIET AND TEETH
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Boston Medical Library
Authors: Walter G. Phippen
Journal: New England Journal of Medicine (1951)

REPORT OF THE PRESIDENTTo the Trustees and Fellows of the Boston Medical Library: I have the honor to present my fifth annual report as President.The library continues to grow both in number of volumes and in circulation. Since Dr. Viets' message will tell you something about our acquisitions during the year, I want particularly to call your attention to our growth in circulation. Circulation of books is a direct measure of the usefulness of the library. Our growth in this respect during the past five years has been quite remarkable. In 1946 38,226 volumes were taken from the . . .
Charaka-Samhita.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The management of mitral valve prolapse
Authors: Robert Lebow, James A. Ross
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We congratulate Dr Jeresaty<sup>1</sup>on an excellent and encyclopedic review of mitral valve prolapse. It is certainly true that one must avoid establishing correlations between medical entities through anecdotal rather than statistical analysis. We agree that the mitral valve prolapse syndrome is likely to be more apparent than real.<sup>2</sup> However, it must be recognized that there appears to be a relation between mitral valve prolapse and the autoimmune thyroid diseases, Graves' disease, and chronic lymphocytic thyroiditis, apparently through a common etiologic factor or factors. This is marginally supported through a variety of different studies, including HLA antigen determinations.<sup>3</sup> Therefore, it may be wise to screen patients with mitral valve prolapse for these entities through appropriate testing. This awaits further study.