tbuckley/cabot-search huggingface dataset:
The science of the art of geriatric medicine
Authors: E. C. Hadley
Journal: JAMA (1995)

Two fundamental precepts of geriatrics are the importance of evaluating the whole person and matching therapy to that person's specific conditions and circumstances.<sup>1-4</sup>The high prevalence of coexisting multiple diseases among older persons, the interactions of physiological systems affecting functional decline, and the heterogeneity of the older population create complex problems in deciding what information to obtain about a patient and applying it in clinical decisions. These complexities are often so great that good decision making in geriatrics may often be seen as more art than science. Although art will probably always play a role in all fields of medicine, advances in geriatric research are providing a more scientific context for applying the geriatrician's integrative art to an expanding range of important clinical problems. The articles by Tinetti et al<sup>5</sup>and Ouslander et al<sup>6</sup>in this issue of<i>JAMA</i>reflect different aspects of these approaches. Both studies
Platelet aggregates and the microcirculation
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The use of telemetering capsules in disorders of the alimentary tract: Part II The application to the study of human gastro-intestinal motility
Journal: Gut (1962)

Methods and techniques 371 the human alimentary tract by the use of a capsule containing a pressure-sensitive transducer and radio transmitter is described.The method exploits a difficulty inherent in this new technique, namely, that of the maintenance of the link between radio transmitter and receiver.A technique for the combined recording of pressure change and movement of the capsule is described.'The capsule was manufactured by Solartron Ltd.
Fire ants are stinging nine southern states
Authors: P. Gunby
Journal: JAMA (1979)

At least some of them apparently slipped into this country via a South American ship 50 or 60 years ago. They have prospered, become a problem, and defied all efforts to get rid of them. Who are these illegal immigrants? The fire ants (<i>Solenopsis</i>). Physicians at the American Academy of Allergy meeting in New Orleans reported treating increasing numbers of human allergic reactions to the fire ant sting. (One reason for the fire ant's name is that its sting is said to feel much like a burn.) The reactions are often extremely serious. A number of deaths have occurred, and some fingers and toes have required amputation, according to the American Farm Bureau. Another type of case was reported by a chemist in a letter to the Environmental Protection Agency (EPA) in Washington, DC. On three separate occasions, he wrote, he was stung by fire ants. Within several weeks, skin
Antibiotic Treatment of Pelvic Inflammatory Disease
Authors: David A. Grimes
Journal: JAMA (1986)

Although pelvic inflammatory disease is the most common serious infection among young women of reproductive age in the United States, no nationwide data are available on the patterns of antibiotic treatment of this disease. To examine these patterns we analyzed over 25 million antibiotic prescriptions for treatment of pelvic inflammatory disease from 1966 through 1983, using the National Disease and Therapeutic Index. Most patients received a single antibiotic on an outpatient basis. Overall, use of natural penicillins declined markedly, and use of aminopenicillins more than doubled. Cephalosporins emerged as the most frequently prescribed antibiotic for hospitalized patients. Nationwide surveillance of treatment patterns may help to identify areas needing improvement through continuing education. (<i>JAMA</i>1986;256:3223-3226)
Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler (P-MDI)
Authors: RW Fuller, RK Sharma, A Cripps
Journal: European Respiratory Journal (1995)

Lung deposition of budesonide from Turbuhaler ā ā ā ā ā is twice that from a pressurized metered-dose inhaler (P-MDI).
Tobacco’s Continuing Health Threat
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
British Journal of Medical Education, London
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious diseases
Authors: M. Y. Stoeckle
Journal: JAMA (1992)

The effort to create an effective human immunodeficiency virus (HIV) vaccine has moved to the forefront of acquired immunodeficiency syndrome (AIDS) research. As recently as a few years ago, there was widespread pessimism as to the possibility of an HIV vaccine. The change has been propelled by reports from several laboratories that inactivated or recombinant simian immunodeficiency virus vaccines can induce protective immunity in monkeys. The finding of vaccine-induced immunity to simian immunodeficiency virus, a virus closely related to HIV, suggests that protective immunity against HIV is achievable. Multiple strategies of inducing HIV immunity are being tested, including administration of inactivated virus, recombinant viral proteins, or recombinant live vaccines that express viral antigens. Use of recombinant live vectors, such as Calmette-Guerin bacillus, may be particularly useful in inducing cell-mediated immunity.<sup>1</sup> Pilot studies on the safety and immunogenicity of HIV vaccines are encouraging. For example, phase I trials of a
Annals Otol, Rhinol, &amp; Laryngology, St. Louis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Coronary Calcification Scores to Predict Coronary Heart Disease
Authors: Matthew J Budoff, James Ehrlich, Harvey S Hecht, John A Rumberger
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sampling distributions
Authors: P. Sedgwick
Journal: BMJ (2009)

Researchers obtained birth weights for 4300 men born between 1973 and 1975. The mean birth weight was 3471 grams and the standard deviation was 540 grams. The 95% confidence interval for the mean was 3455 grams to 3487 grams. Which of the following statements best describes the information given by the 95% confidence interval?
Acute hepatitis C virus infection: a prospective ten-year observational study of HCV-mono and HCV/HIV-coinfected patients
Authors: Christiana Graf, Lutz Thomas, Gaby Knecht, Christoph Stephan, Peter Gute, Kai-Henrik Peiffer, Johannes Vermehren, Stefan Zeuzem, Julia Dietz, Christoph Sarrazin
Journal: Journal of Hepatology (2020)
Rheumatoid arthritis: a psychiatric assessment
Authors: G H B Baker, D A Brewerton
Journal: BMJ (1981)

Ketotifen overdose: surveillance of the toxicity of a new drug An error occurred in the table of this paper by Drs D B Jefferys and G N Volans (30 May, p 1775).The plasma concentrations of ketotifen should have been expressed in ,ug/l, not mg/I.
Value of molecular epidemiologic analysis in a nosocomial methicillin-resistant Staphylococcus aureus outbreak
Authors: F. C. Fang
Journal: JAMA (1993)

<h3>Objective.</h3> —To evaluate two molecular epidemiologic methods used in the analysis of a nosocomial methicillin-resistant<i>Staphylococcus aureus</i>(MRSA) outbreak. <h3>Design.</h3> —Restriction endonuclease analysis of plasmid DNA (REAP) was used in the analysis of 45 MRSA isolates. After termination of the outbreak, isolates were retrospectively analyzed in a blind fashion using the newly described technique of arbitrarily primed polymerase chain reaction (AP-PCR). Molecular analyses were compared with epidemiologic and antimicrobial susceptibility data. <h3>Setting.</h3> —Tertiary care university hospital. <h3>Subjects.</h3> —Twenty-eight patients and 12 employees infected or colonized with MRSA during a 6-week period. <h3>Results.</h3> —A clonal relationship demonstrated among isolates from burn unit patients and staff was clearly distinguishable from MRSA isolates arising from other hospital wards. The combination of REAP and AP-PCR provided complementary information in several instances. Aggressive measures to isolate infected patients and eradicate colonization from patients and staff terminated the outbreak. <h3>Conclusions.</h3> —Although traditional epidemiologic methods retain their central role in modern hospital infection control, molecular epidemiologic analysis can significantly enhance the ability of infection control officers to analyze and terminate hospital epidemics. The combination of AP-PCR and REAP may prove to be a particularly informative means of tracking the nosocomial spread of microbial strains and their mobile genetic elements. (<i>JAMA</i>. 1993;270:1323-1328)
Acute myelofibrosis. Treatment with allogeneic bone marrow transplantation
Authors: J. F. Kroener
Journal: JAMA (1983)

ACUTE<i>myelofibrosis</i>is one of several names given to a disease first described in 1963 by Lewis and Szur,<sup>1</sup>which they designated as<i>malignant myelosclerosis</i>. They reported five cases of an acute fatal illness characterized by anemia without adenopathy or splenomegaly, a peripheral blood picture like that of acute leukemia, and a bone marrow biopsy specimen demonstrating marked fibrosis. Since then, numerous cases have appeared in the literature and have been reviewed by Bearman et al,<sup>2</sup>who have proposed a set of diagnostic criteria. The disease has been uniformly fatal despite treatment attempts with steroids, androgens, and chemotherapy, although no uniform attempt has been made to evaluate the results of treatment with combination chemotherapy. Recently, Smith et al<sup>3</sup>and Wolf et al<sup>4</sup>have reported treatment of five patients with acute myelosclerosis with chemotherapy and allogeneic bone marrow transplantation. Four patients had prompt engraftment and resolution of
THE COOPERATIVES TRY TO CO-OP
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THOMAS HODGKIN— QUAKER PHYSICIAN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Multistate outbreak of sporotrichosis in seedling handlers, 1988
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts of papers submitted to the American Association for the Study of Liver Disease
Authors: A Thiazide, Diuretic Ke, Cholerkiy Ms, Heqner Dept, C H R I S T I Quantitation, F Datz, R Abrams, R Stevens, J Clark, G Musto, A Berlet, Rd Soloway
Journal: Hepatology (1981)

Thiazide diuretics are generally believed not to alter hepatic heme metabolism.However in studies of the effects of widely used drugs on porphyrin-heme synthesis we found methyclothiazide to be a potent inducer of 8-aminolevulinate synthase (ALAS), as well as cytochrome P-450 in the chick embryo liver kn.ALAS is rate-limiting for hepatic heme synthesis.Dose-response studies showed these actions of methyclothiazide to be more marked than for the well-known inducer, phenobarbital.As noted earlier (BBA =:313,1978), related drugs lacking a 2-methyl and a 3-chloromethyl substituent, such as chlorothiazide, hydrochlorothiazide and trichlormethiazide are not ALAS or P-450 inducers,suggesting that one or both of these substituents is important in the inducing actions of methyclothiazide.* ALAS P-450 Porphyrin (at 6 h) (at 24 h) (at 24 h) Dose per embryo (nmol/h'g) (nmol/g) (nmol/g) Control 21 0.15 10.4 Phenobarbital 2 mg 218 -69.1 Methyclothiazide 0.05 mg 100 -12.9 0.2 mg 191 -54.9 1 mg 544 190 662 -211 5 mg * 230 10 mg 523 1.12 5 mg 485 0.42 192After a small "priming" dose of 1,4-dihydro-3,5-dicarbethoxycollidine (0.25 mg) to enhance porphyrin accumulation.This study shows that the actions of closely related drugs on heme biosynthesis need to be evaluated individually.is misleading, after examining only a few structurally related drugs, to generalize as to the effects of a whole class'of therapeutic agents such as the thiazide diuretics, on the heme pathway.Methyclothiazide should be regarded as a potentially unsafe drug in patients with acute intermittent porphyria, and the possibility considered that it may increase cytochrome P-450 content in other species including humans, and thus alter the disposition of drugs metabolized by P-450 dependent enzymes. It
Letter: Flupenthixol for depression.
Authors: Neil Beneck, Mitchell Levy, Lonnie Walter
Journal: BMJ (1976)

about 1 cm without discoloration or tenderness.The remainder of the physical examination, including visual field and ophthalmoscopic examination, was normal.Laboratory investigations, including complete blood count, differential white cell count, serum electrolytes, chest x-ray, urine analysis, blood urea nitrogen, creatinine, and glucose, examination for antinuclear antibody and rheumatoid factor, and serum protein electrophoresis, were normal and serological test for syphilis was negative.The erythrocyte sedimentation rate (Westergren) was 4 mm in 1 h on three determinations.After the third day in hospital the swelling decreased by about half and, since the patient remained free from other symptoms, she was discharged home.Diagnoses entertained included cranial arteritis, trauma, autoerythro- cyte sensitivity, and allergic reaction, but none was established.
Preventive Medicine
Authors: Cecil G. Sheps
Journal: JAMA (1979)

The continuously rising cost of medical care and the recognition that these increased expenditures do not seem to be accompanied by commensurate gains in the health status of the population have helped to focus our attention on disease before it happens, ie, on prevention. At the same time, we have learned a great deal about the factors that produce or are associated with the leading causes of death and disability. Evidence mounts to implicate personal behavior and the physical and socioeconomic environment as prime determinants of health and disease; hence, the rising interest in health policy discussions. I shall broadly sketch the objectives, scope, problems, and challenges in the types of programs of prevention now emerging.<sup>1</sup> <h3>Levels of Prevention</h3> Prevention measures are either primary or secondary. Primary prevention consists of those actions that prevent a disease from occurring. Secondary prevention consists of activities designed to detect disease before it