tbuckley/cabot-search huggingface dataset:
P676Mechanisms of sinoatrial node dysfunction in RyR2(R420Q) mice model of catecholaminergic polymorphic ventricular tachycardia
Authors: YY Wang, O Villejoubert, A Zahradnikova, JP Benitah, A Gomez
Journal: Cardiovascular Research (2014)

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disease characterized by stress-induced syncope and/or sudden death in young individuals with structurally normal heart. More than 150 mutations located in the cardiac Ca2+ release channel (type-2 ryanodine receptor, RyR2) gene are related to CPVT. Besides ventricular tachycardia (VT) under stress, sinoatrial node (SAN) dysfunction is frequently observed in CPVT patients. However, the cellular mechanisms remain underexplored. We created a KI mice model bearing a mutation in the N-terminal portion of the RyR2 found in a CPVT family, RyR2(R420Q). ECGs were recorded in KI and WT littermates in resting condition and after epinephrine/caffeine (2/120 mg/kg) challenge (i.p. injection). All KI mice (n=7) showed sustained bidirectional VT, validating the model. Moreover, resting heart rhythm was slower in KI mice during rest period (525.3±9.0 bpm n=4 and 498.5±4.9 bpm n=3, P<0.05), denoting alteration in SAN function. To examine the mechanisms of this dysfunction, SANs were dissected from WT and KI mice, loaded with the cell-permeant Ca2+ dye, Fluo-4 AM, and viewed by confocal microscopy using a white light laser fitted to 500 nm and resonant scanning. The cycle length of spontaneous [Ca2+]i transients was significantly longer in KI mice (696±2ms in 70 WT cells vs. 994±5ms in 48 KI cells, P<0.0001). [Ca2+]i transient amplitudes were reduced in KI cells (peak F/F0: 3.2±0.2, n= 43, p<0.05) compared to WT cells (peak F/F0: 3.7±0.1, n= 67), but with similar kinetics. Ca2+ sparks frequency between spontaneous beats was similar between KI and WT but the time to peak (22.8±0.4ms in 938 WT Ca2+ sparks vs. 41.2±0.7ms in 1617 KI Ca2+ sparks, P<0.0001) and duration were prolonged in KI mice (duration at half maximum: 34.1±0.5ms, n=1135 WT; vs. 57.8±0.6ms n=2237 KI, P<0.0001). In conclusion, our data show that RYR2R420Q SAN mutation: 1) induce CPVT phenotype in mice, 2) decreases the SAN rhythm, 3) promotes more [Ca2+]i leak during diastole. These alterations may contribute to supraventricular arrhythmia in CPVT.
Delayed hypersensitivity to penicillin. Clinical significance and hyposensitization after therapy
Authors: J. M. Fellner
Journal: JAMA (1969)

Delayed skin-test hypersensitivity to penicillin G potassium has been associated with the occurrence of exanthematous, erythrodermic, local indurative, and generalized pruritic adverse clinical reactions to therapeutic doses of penicillin. A pronounced regular decrease in delayed skin-test hypersensitivity to penicillin G followed the administration of therapeutic doses of penicillin. In about one half of the patients, the delayed hypersensitivity was, at least temporarily, completely abolished. Preliminary data suggest that with the doses of penicillin given to our patients the decrease in delayed hypersensitivity lasts for a period of a few weeks to about five months.
Abstract 12381: Ast-120, an Adsorbent of Uremic Toxins Normalized the Cardiac Hypertrophic/pro- Apoptotic And Cardioprotective/anti-apoptotic Signaling in Pacing-induced Heart Failure in Dogs
Authors: Hyemoon Chung, Hiroshi Asanuma, Shin Ito, Kyung-Duk Min, Kazuhiro Shindo, Miki Imazu, Hiroki Fukuda, Hiroko Takahama, Masanori Asakura, Masafumi Kitakaze
Journal: Circulation (2015)

Background: Renal dysfunction increases the plasma levels of indoxyl sulfate (IS), a uremic toxin excreted from the kidney. Interestingly, IS is reported to directly stimulate both collagen synthesis and cardiomyocyte hypertrophy in vitro via the modulation of ERK and p38-MAPK. However, it is unclear whether the pathophysiology of heart failure (HF) changes such intracellular signaling via the IS-dependent pathways. AST-120 is known to inhibit the uptake of indole and decrease the plasma IS levels. Hypothesis: We tested the hypothesis that the removal of plasma IS by using AST-120 modulates the intracellular signaling for hypertrophy, collagen synthesis and apoptosis of the myocardium in the canine HF model in vivo. Method: A canine HF model was produced by continuous rapid ventricular pacing at 230 bpm for 6 weeks. We treated the canine with oral AST-120 (1g/kg/day) administration between 4th and 6th week following the onset of rapid pacing (HF with AST-120 group, HF without AST-120 group, n=7 in each). We also set a control (Control group, n=7) without pacing for 6 weeks. We extracted the protein from the hearts and analyzed it by Western blotting. Result: AST-120 treatment reduced both plasma IS elevated in the canine HF model. HF without AST-120 group showed the activation of ERK signaling and the deactivation of both Akt and p38-MAPK signaling compared with Control group. The treatment with AST-120 increased the phosphorylation levels of Akt and p38-MAPK, and suppressed the ERK phosphorylation. HF without AST-120 group also showed an increased expression of pro-apoptotic Bax protein, and a decreased expression of anti-apoptotic Bcl-2 protein. The increased Bcl-2/Bax ratio was significantly ameliorated by AST-120 treatment. Conclusion: The decreases in plasma levels of indoxyl sulfate by the treatment with AST-120 1) deactivates the cardiac hypertrophic signaling, 2) activates the cardiac survival and anti-apoptotic signals and 3) suppresses the pro-apoptotic signals in failing heart in vivo. Indoxyl sulfate may become a sensitive and novel biomarker/mediator of heart failure explaining the cardio-renal syndrome that links renal dysfunction to heart failure.
Annual Report of the Department of Health of the City of Cincinnati.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mutations of the ELA2 Gene Found in Patients with Severe Congenital Neutropenia Induce the Unfolded Protein Response and Cellular Apoptosis.
Authors: Mark A. Murakami, David S. Grenda, Jhuma Ghatak, Laurence A. Boxer, David C. Dale, Mary C. Dinauer, Audrey Anna Bolyard, Daniel C. Link
Journal: Blood (2006)
The Immunobiology Of T Cells With Invariant Gamma-Delta Antigen Receptors
Authors: J. Allison
Journal: Annual Review of Immunology (1991)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Abstract P275: Hypertension, Diabetes, and Obesity Among African Immigrants in the 2010 - 2014 National Health Interview Surveys
Authors: Ruth-Alma N Turkson-Ocran, Nwakaego A Ukonu, Yvonne Y Commodore-Mensah
Journal: Circulation (2017)

Background: Cardiovascular disease (CVD) is the leading cause of death in the United States (US). Immigrants of African-ancestry are a fast-growing population in the US. However, little is known about the prevalence of CVD risk factors such as hypertension, diabetes, and obesity in this population. Hypothesis: We hypothesized that sex-differences exist in the prevalence of cardiovascular risk factors among African immigrants. Methods: We performed a retrospective analysis of the National Health Interview Surveys for the 2010-2014 period. We examined demographic and CVD history variables to determine if differences existed by sex in the prevalence of CVD risk factors. We performed multivariable logistic regression analyses and computed predictive margins (with standard errors) to obtain the predicted probabilities of hypertension, diabetes, overweight/obesity, and hyperlipidemia. Results: A total of 2,019 adult African immigrants were included in the sample. Table 1 describes the socio-demographic characteristics of the respondents. Overall, 61% (1234 of 2019) of the sample was overweight/obese, 18% (403 of 2019) were hypertensive, and 16% (47 of 2019) had a history of CVD. Males were significantly more likely than females to have diabetes (OR(95% CI):1.79(1.16,2.78); p&lt;0.05). Females had a 0.42 (95% CI: 0.21-0.83; p=0.01) odds of hyperlipidemia compared to males and females were 0.76 (95% CI: 0.59-0.99; p&lt;0.05) times less likely to be hypertensive compared to males. There was no difference in the prevalence of overweight/obesity between the sexes. Conclusion: In conclusion, we observed significant sex-differences in the prevalence of hypertension, diabetes, and hyperlipidemia. It is important to highlight sex-differences in CVD risk factors among African immigrants to inform the development of effective preventative health interventions. Culturally-appropriate public health strategies and policies designed to meet the specific needs of African immigrants may reduce the prevalence of CVD risk factors and improve health outcomes.
Whither medical education? A sometimes inflexible system faces change
Authors: E. Friedman
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase I study of r-(-)-gossypol (AT-101, NSC 726190) in combination with cisplatin (P) and etoposide (E) in patients with advanced solid tumors and extensive-stage small cell lung cancer (ES-SCLC).
Authors: T. A. Leal, W. R. Schelman, A. M. Traynor, J. Kolesar, R. M. Marnocha, J. C. Eickhoff, D. B. Alberti, N. Takebe, G. Wilding
Journal: Journal of Clinical Oncology (2010)

e13030 Background: AT-101 [R-(-)-gossypol acetic acid] (AT) is an orally administered BH3 mimetic that lowers the threshold for apoptosis by direct binding to Bcl-2, Bcl-xL, Mcl-1, and Bcl-W. Combinations of AT and cytotoxic drugs demonstrated synergistic antitumor effects in vitro and in vivo SCLC models. We completed a dose-escalation study of AT in combination with cisplatin and etoposide (EP), in which neutropenia was dose- limiting. The objectives of this study were to determine the maximum tolerated dose (MTD)/recommended phase II dose (RP2D) of AT when combined with EP with pegfilgrastim (F) in patients with advanced solid tumors. Methods: Standard phase I eligibility criteria were used. Prior therapy with Bcl2-inhibitors was not allowed. We previously reported the MTD without F established at AT 20 mg BID days (D) 1-3, P 60 mg/m2 D 1, E 100 mg/m2 D 1-3 every 21 days (Leal, JCO 2009; 27(15S), e13502). Patients were enrolled in 3 additional dose levels (DL) with F support (6 mg SQ D 4): DL1a (AT 30 mg BID, P 60 mg/m2, E 100 mg/m2), DL2a (AT 30 mg BID, P 60 mg/m2, E 120 mg/m2), and DL3a (AT 40 mg BID, P 60 mg/m2, E 120 mg/m2). Results: 12 patients were enrolled: 8 men, 4 women. Tumor types: 4 non-small cell lung cancer (NSCLC), 1 ES-SCLC, 2 esophageal, 2 neuroendocrine, 1 prostate, 1 adrenocortical, 1 gallbladder. No dose limiting toxicities occurred. Grade 3/4 treatment-related toxicities included: 2 episodes of diarrhea (1 DL1a, 1 DL3a), and 1, each, of elevated ALT (DL1a), hypokalemia (DL1a), fatigue (DL2a), neutropenia (DL2a), anemia (DL3a), hypophosphatemia (DL3a), and pulmonary embolism (DL3a). Two patients with NSCLC and 1 with neuroendocrine had a PR. Pharmacokinetic data will be available for presentation. Conclusions: The MTD/RP2D with F support was established at AT 40 mg BID on D 1-3, P 60 mg/m2 D 1, and E 120 mg/m2 D 1-3 every 21 days. F support permits full doses of cytotoxics to be administered. Antitumor activity was observed in patients with lung cancer and neuroendocrine tumor. Accrual to an MTD expansion cohort of patients with untreated ES- SCLC is ongoing. This study was supported by NCI UO1 CA062491, SAIC 25XS097, and 1ULRR025011. No significant financial relationships to disclose.
Question and Answers
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Zeitschrift fur Orthopädie, Stuttgart
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Violent Attachments
Authors: Carl C. Bell
Journal: JAMA (1993)

In this book the author achieves his goal of theoretically and empirically investigating violence using concepts of attachment and object relations theories. After a thorough introduction to the pertinent theories, Dr Meloy asserts that deviations from normative attachment in infancy and childhood may have important pathological characterologic sequelae in adulthood. In addition, he illustrates how attachment pathology and violence go hand in hand. He argues that, despite a profound emotional detachment from others (which is due to a complete failure to make an attachment in infancy, leading to affectionless psychopathy), psychopathic individuals often have a paradoxical need to relate with people in a repetitive and aggressive manner, causing them to be particularly suited for predatory violence. Further, the intrapsychic aspects of these violent attachments are organized at the borderline or psychotic level of personality organization. The author uses empirical research on erotomanic patients; individuals who commit catathymic homicide (a sudden,
Brief Report:
Journal: JAMA (2004)

14-16 days after contact with the adopted child, and measles was diagnosed.No other cases linked to this outbreak have been identified.The cases in adoptees were associated with the Zhuzhou Child Welfare Institute in Hunan Province.On May 24, Chinese authorities reported that the last patient with measles at the orphanage had rash onset on April 23, and that the recommended vaccination campaign for all eligible children at the orphanage had been completed.Because no cases of measles were reported from the orphanage during the next 21 days (i.e., one incubation period), the outbreak appears to have been controlled.As a result, CDC is recommending that standard adoption procedures for children from the orphanage be resumed.
A Randomized Phase 3 Study of Tipifarnib Compared to Best Supportive Care (Including Hydroxyurea) in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML) in Patients 70 Years or Older.
Authors: Jean-Luc Harousseau, Giovanni Martinelli, Wieslaw W. Jedrzejczak, Joseph Brandwein, Dominique Bourdessoule, Tamas Masszi, Gert Ossenkoppele, Julia A. Alexeeva, Gernot Beutel, Youn C. Park, Peter De Porre, Angela J. Howes
Journal: Blood (2007)
Trends in Screening Mammograms for Women 50 Years of Age and Older—Behavioral Risk Factor Surveillance System, 1987
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Substance Abuse Prevention Program— Albuquerque, New Mexico
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
State-Specific Prevalence of Participation in Physical Activity—1994
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis of intra-abdominal and pelvic abscesses by computerized tomography
Authors: P. R. Koehler
Journal: JAMA (1980)

Review of the medical records and x-ray films of 110 patients with the diagnosis "rule out abscess" showed that computerized tomography (CT) was able to correctly identify and localize a lesion in 78/79 patients. In five patients an uninfected mass was found by CT. Of 32 patients in whom no abscess was shown, only one had an abscess requiring drainage. Computerized tomography was particularly helpful in the postoperative patients in whom ultrasound examinations are difficult to perform. In many patients aspiration or drainage procedures were done at the time of examination, thus allowing us to reach immediately a final diagnosis. Based on this experience, we concluded that CT is an accurate, fast, and cost-effective examination for the diagnosis of abscesses. (<i>JAMA</i>244:49-52, 1980)