tbuckley/cabot-search huggingface dataset:
RECENT OBSERVATIONS ON SCARLET FEVER
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the authors
Authors: S. Chinn, D. Jarvis, P. Burney
Journal: European Respiratory Journal (2006)

The recent paper by CHINN et al. [1], published in the European Respiratory Journal, describing sources of variation of forced expiratory volume in one second (FEV1) and forced vital capacity in the large multicentre European Community Respiratory Health Survey trial, raises important issues in the ongoing debate over the misuse of reference equations in respiratory medicine.The authors demonstrate potentially important population differences, which call into question the application of ethnicity-specific reference equations.However, we believe it is likely that much of the population heterogeneity in the study by CHINN et al. [1] arose from differences in methods, equipment and software.While the authors made some attempts to account for such differences, the level of ''noise'' and the limited site-specific details available (such as quality-control criteria and software versions) would make it hard to demonstrate statistically significant contributions from all sources.
Abstract 79: Overexpression of BQ323636.1 modulates tamoxifen resistance in ER positive breast cancer via IL-8-mediated signaling pathway
Authors: Ling Shi, Ho Tsoi, Miao Dong, Ellen Pui Man, Ui Soon Khoo
Journal: Cancer Research (2019)

Abstract Background Tamoxifen has been used as first-line adjuvant treatment for estrogen receptor positive (ER+) breast cancer; however, the development of acquired resistance compromises its efficacy. Previously, our group identified BQ323636.1(BQ), a novel splice variant of nuclear receptor repressor 2 (NCOR2), which confers tamoxifen resistance by enhancing ER transcriptional activity1, 2. We hypothesize that BQ may also modulate tamoxifen resistance via androgen receptor (AR) activity. The current study investigates the effect of BQ in modulating the activities of ER and AR in tamoxifen resistant breast cancer. Methods In silico search was employed to identify candidate genes that contained both the androgen responsive element (ARE) and estrogen responsive element (ERE) genome-wide. Expression of candidate genes were evaluated by RT-qPCR. Western blot was used to determine the protein expression. Stably transfected BQ overexpressing MCF7 cell line (MCF7-BQ) and control cell line (MCF7-His) were established. ELISA was employed to determine the amount of IL-8. Repertaxin was used to inhibit IL-8 mediated signaling pathway. Results There were 22 candidate genes identified by in silico search. qPCR confirmed that IL-8 gene contained both functional ERE and ARE in MCF-7 cells. Overexpression of BQ could enhance the expression of IL-8 at both mRNA and protein levels. ELISA assay confirmed that BQ overexpression could promote the secretion of IL-8 in breast cancer cells. Western blot analysis showed that BQ overexpression could not alter the expression of IL-8 receptor CXCR1. The treatment with repertaxin could recover the response of MCF7-BQ to tamoxifen. Conclusions Our results suggest that BQ323636.1 could up-regulate IL-8 to modulate tamoxifen resistance. Targeting IL-8 signaling may provide insights to overcome tamoxifen resistance in ER+ breast cancer. References 1. Zhang L., Gong C., Lau S.L.Y., Yang N., Wong O.G.W., Cheung A.N.Y., Tsang J.W.H., Chan K.Y.K. and Khoo US. (2013) Cancer Research 73:246-255 2. Gong, C., Man, E. P., Tsoi, H., Lee, T. K., Lee, ⋯.. Khoo, U. (2018). BQ323636.1, a Novel Splice Variant toNCOR2, as a Predictor for Tamoxifen-Resistant Breast Cancer. Clinical Cancer Research,24(15), 3681-3691. doi:10.1158/1078-0432.ccr-17-2259 Citation Format: Ling Shi, Ho Tsoi, Miao Dong, Ellen Pui Man, Ui Soon Khoo. Overexpression of BQ323636.1 modulates tamoxifen resistance in ER positive breast cancer via IL-8-mediated signaling pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 79.
Almost no evidence exists that the internet harms health
Authors: R. Smith
Journal: BMJ (2001)

Medical journals are riddled with errors and are improving only slowly, and medical editors are neglecting their craft.These were the conclusions of Drummond Rennie, deputy editor of JAMA, at the end of the fourth congress on peer review in biomedical publication organised by JAMA and held in Barcelona this week.The conference heard from Doug Altman, statistical adviser to the BMJ, how medical journals continue to be full of serious methodological errors, meaning that many studies reach false conclusions.The problem was identified many years ago, and yet there have been few improvements.Medical research is too often done by untrained people for the wrong reasons, including career advancement.
Discovery of Adverse Drug Reactions
Authors: Allen C. Rossi
Journal: JAMA (1983)

Following a Food and Drug Administration review of three major phase IV studies involving from 7,607 to 22,653 persons, it was determined that none of the studies resulted in the detection of new adverse drug reactions (ADRs). For two of the three drugs studied, new ADRs were identified after approval. The discovery of these new ADRs was attributed to physician case reports obtained through concurrently operating spontaneous reporting mechanisms. (<i>JAMA</i>1983;249:2226-2228)
Part-time residency training
Authors: E. Weinberg
Journal: JAMA (1969)

In order to make medicine a more feasible career choice for women and in order to increase the level of training and, therefore, the quality of practice, it is important to decrease the scheduling rigidity of standard residency training programs. The steadily increasing numbers of women in medical school makes the problem more pressing at this time. This communication reports the result of a survey of the specialty boards concerning the acceptability of part-time training. In most cases the boards will consider this kind of training on an individual basis. Part-time specialty training does merit a trial.
Bernard Siegfried Albinus (1697-1770), German-Dutch anatomist
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mitral Valve Disease in <i>Circulation</i> and the <i>Circulation</i> Subspecialty Journals
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the articles related to mitral valve disease that were published in Circulation and the Circulation subspecialty journals in 2010 and 2011.
Patterns of care for omission of radiation therapy for elderly women with early-stage breast cancer receiving hormonal therapy.
Authors: Peyman Kabolizadeh, Malolan Sri Rajagopalan, Paniti Sukurmvanich, Joseph L Kelley, Gretchen M. Ahrendt, Dwight Earl Heron, Sushil Beriwal
Journal: Journal of Clinical Oncology (2014)

1032 Background: For well-selected elderly women who undergo segmental mastectomy for early-stage, ER+ breast cancer, hormonal therapy alone is emerging as an acceptable adjuvant therapy option since the initial publication of CALGB 9343 study in 2004 and update in 2013. The rate of adoption of adjuvant hormonal therapy alone in lieu of radiation therapy (RT) and its associated patterns of care is the subject of this study. Methods: The National Cancer Data Base (NCDB) is a oncology outcomes database, which captures 70% of all newly diagnosed cancer patients in the US. We utilized NCDB to identify women aged ³70 diagnosed with T1N0/T1Nx invasive breast cancer who underwent segmental mastectomy from 1998-2011. Only those who received hormonal therapy were included in this analysis. Univariate and multivariable exploratory analyses were performed. Results: Of the 182,115 patients who met inclusion criteria, 97,530 (53.6%) patients underwent hormonal therapy and were included in the analysis. The rate of utilization of RT in this subset decreased with time from 84.9% in 1998 to 75.1% in 2011 (p<0.001). Academic sites decreased RT utilization most rapidly over this time period where in 2011 the rate of RT utilization was 70.7% as compared to 75.0% and 77.0% in community and comprehensive community facilities respectively (p<0.001). From 2003 to 2005 (prior to and following the initial publication of CALGB 9343), RT utilization rate decreased from 88.2% to 78.4%. Multivariable analysis revealed that the factors associated with decreased use of RT include (in order of association): older age, later year of diagnosis, lack of insurance, low grade histology, treatment at academic site, race, rural location, greater comorbidity score, lower median income, and distance from center. Conclusions: This study comprehensively assesses the patterns of care associated with the omission of radiation therapy in elderly women with early-stage breast cancer who only received adjuvant hormonal therapy. Since the publication of major clinical trials, this strategy has been increasingly adopted. The strongest predictors of the use of this strategy included advanced patient age at presentation and low-grade disease.
Liver hepatocyte growth factor does not always correlate with hepatocellular proliferation in human liver lesions: Its specific receptor c-met does.
Authors: A D'Errico
Journal: Hepatology (1996)

Increased levels of expression of hepatocyte growth factor (HGF) and its specific receptor c-met have been shown in the liver of several benign and malignant pathologies, both in experimental models and humans. We investigated by immunohistochemistry the presence of both HGF and c-met protoocogene product (c-met pp) in 20 hepatocellular carcinomas (HCCs), 5 focal nodular hyperplasias (FNHs), 4 cases of fulminant hepatitis (FH), and 1 case of regenerated liver. The c-met protooncogene product was expressed in all cases with marked overexpression in the HCCs and in ductular metaplasia. HGF was detected in the Ito cells of all cases and in neoplastic hepatocytes of 9 of 20 HCCs (45%). The proliferative index of each lesion was evaluated by means of the polyclonal antibody anti-cyclin A. When the level of expression of HGF and c-met protooncogene product with the percentage of cyclin A+ nuclei were compared, the closest relationship was between c-met protooncogene product and cyclin A+ nuclei were compared, the closest relationship was between c-met protooncogene product and cyclin A. In 11 of 20 HCCs (55%), there wa no correlation between HGF positivity and cyclin A. This seems to suggest that, independently of the levels of native liver HGF, c-met protooncogene product is the most active modulator of liver cell proliferation. (Hepatology 1996 Jul;24(1):60-4)
Scientific Exhibit
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A population-based twin study of alcoholism in women
Authors: K. S. Kendler
Journal: JAMA (1992)

<h3>Objective.</h3> —To clarify the role of genetic factors in the etiology of alcoholism in women. <h3>Design and Setting.</h3> —Personal structured psychiatric interviews conducted by researchers "blinded" to the status of the co-twin in an epidemiologic sample of 1030 female-female twin pairs of known zygosity from the population-based Virginia Twin Registry. <h3>Measures.</h3> —Three definitions of lifetime prevalence of alcoholism based on<i>Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised</i>criteria: (1) alcoholism with tolerance or dependence; (2) alcoholism with or without tolerance-dependence; and (3) alcoholism with or without tolerance-dependence or problem drinking. <h3>Results.</h3> —Using narrow, intermediate, or broad definitions, the probandwise concordance for alcoholism was consistently higher in monozygotic than in dizygotic twin pairs. Multifactorial threshold models suggested that the heritability of liability to alcoholism in women is in the range of 50% to 60%. <h3>Conclusions.</h3> —The results support the hypothesis that genetic factors play a major role in the etiology of alcoholism in women. Women should be well represented in the efforts currently under way to elucidate the molecular basis of the genetic susceptibility to alcoholism. (<i>JAMA</i>. 1992;268:1877-1882)
Exposure to Polychlorinated Biphenyls and Levels of Thyroid Hormones in Children
Authors: Nadia Osius, Wilfried Karmaus, Hermann Kruse, Jutta Witten
Journal: Environmental Health Perspectives (1999)

As part of an epidemiologic study on exposure to a toxic waste incineration plant we investigated whether blood concentrations of polychlorinated biphenyls (PCBs), lead, and cadmium, as well as concentration of mercury in 24-hr urine samples were associated with thyroid hormone status. As an indication of status, we determined levels of thyroid-stimulating hormone (TSH), free thyroxine (FT(4)), and free triiodothyronine (FT(3)) in children living in households where [less than/equal to] 10 cigarettes were smoked per day. Eight PCB congeners (PCBs 101, 118, 138, 153, 170, 180, 183, and 187) were measured in whole blood samples. Of these, seven congeners (PCB 101 was not detected in any sample) and the sum of all PCB congeners were analyzed as predictors for thyroid hormone status in separate linear regression models adjusted for potential confounders. In addition, the possible effects of cadmium, lead, and mercury on levels of thyroid hormones were examined. Blood concentrations and information on questionnaire data were available for 320 children 7-10 years of age. We found a statistically significant positive association between the mono-ortho congener PCB 118 and TSH as well as statistically significant negative relationships of PCBs 138, 153, 180, 183, and 187 to FT(3). There was no association for the PCB congeners and FT(4). Blood cadmium concentration was associated with increasing TSH and diminishing FT(4). Blood lead and urine concentration of mercury were of no importance to thyroid hormone levels. The results stress the need for future studies on the possible influences of PCB and cadmium exposure on thyroid hormones, particularly in children. These studies should also take neurologic development into account.
Continuing Medical Education
Authors: Rutledge W. Howard
Journal: JAMA (1972)

The Third National Conference of State Medical Association Representatives on Continuing Medical Education will be held by invitation at the Ambassador Hotels, Chicago, Oct 24-26, 1972. The first two conferences have appeared to be productive and helpful, not only to the state association leadership, but to the state association individual members as well. The primary interest of these conferences has been to study the state-level problems in continuing medical education and to suggest solutions by which the state medical associations might be able to help solve those problems. The conferences have provided forums for the exchange of ideas among representatives of the various state associations. They have given strong encouragement to these associations to become more involved in the field. The Third Conference will focus its attention on several major interests of all physicians. It is planned that the program will include discussion of problems related to peer review as
ENROLMENT FORM AND QUESTIONNAIRE FOR PROCUREMENT AND ASSIGNMENT SERVICE
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anticardiolipin antibody.
Authors: G. R. Hughes, M. A. Khamashta
Journal: BMJ (1989)

tance of the oropharynx2 22 and stomach, and of preserving gastric acidity, should be defined.Selective decontamination of the digestive tract may be helpful, however, in preventing infection in long stay patients with trauma who are being ventilated and in removing organisms during outbreaks.What selective decontamination of the digestive tract has done is to open new approaches for investigating and possible intervention of an intractable problem.
Comparison of the Drugs Fluconazole or Itraconazole To Treat Coccidioidomycosis Infection
Journal: Annals of Internal Medicine (2000)

Summaries for Patients7 November 2000Comparison of the Drugs Fluconazole or Itraconazole To Treat Coccidioidomycosis InfectionSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-9-200011070-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Coccidioidomycosis is an infection due to a fungus (Coccidioides immitis) found in Arizona, central California, and other southwestern U.S. states and in parts of Central and South America. Of every three people who get this infection, only one becomes ill. Illness most often involves the lungs but can also involve the skin, lymph nodes, joints, and bone. In people with abnormal immune systems, coccidioidomycosis can also cause meningitis, which is an infection of the lining that covers the brain and spinal cord. Fluconazole and itraconazole are drugs taken ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Comparison of Oral Fluconazole and Itraconazole for Progressive, Nonmeningeal Coccidioidomycosis. A Randomized, Double-Blind Trial.” It is in the 7 November 2000 issue of Annals of Internal Medicine (volume 133, pages 676-686). The authors are JN Galgiani, A Catanzaro, GA Cloud, RH Johnson, PL Williams, LF Mirels, F Nassar, JE Lutz, DA Stevens, PK Sharkey, VR Singh, RA Larsen, KL Delgado, C Flanigan, and MG Rinaldi for the National Institute of Allergy and Infectious Diseases–Mycoses Study Group.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComparison of Oral Fluconazole and Itraconazole for Progressive, Nonmeningeal Coccidioidomycosis John N. Galgiani , Antonino Catanzaro , Gretchen A. Cloud , Royce H. Johnson , Paul L. Williams , Laurence F. Mirels , Faris Nassar , Jon E. Lutz , David A. Stevens , P. Kay Sharkey , Vipul R. Singh , Robert A. Larsen , Kathy L. Delgado , Cynthia Flanigan , and Michael G. Rinaldi Metrics 7 November 2000Volume 133, Issue 9Page: I-6KeywordsBoneCoccidioidomycosisDrugsInfectious diseasesLungsLymph nodesMeningitisMouthPatientsSpinal cord ePublished: 7 November 2000 Issue Published: 7 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...