OSTEOPOROSIS
Authors: F ALBRIGHT
Journal: Annals of Internal Medicine (1947)

Article1 December 1947OSTEOPOROSISFULLER ALBRIGHT, M.D.FULLER ALBRIGHT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-6-861 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDR. WARING, MEMBERS OF THE AMERICAN COLLEGE OF PHYSICIANS, AND GUESTS!Osler is quoted as saying: "If you know syphilis, you know internal medicine." Time and medicine have marched on. I think if Osler were here today he would agree to amend his statement to read: "If you know the adrenal cortex, you know internal medicine." With this in mind, I first chose, as the subject of this lecture, "Adrenal Cortical Syndromes and Their Diagnoses." But I soon found I did not know the adrenal cortex!I think I do understand a few things about osteoporosis, which, like everything else,...Bibliography1. ALBRIGHTSMITHRICHARDSON FPHAM: Post-menopausal osteoporosis: its clinical features, Jr. Am. Med. Assoc., 1940, cxvi, 2465-2474. Google Scholar2. ALBRIGHT F: Cushing's syndrome: its pathological physiology, its relationship to the adreno-genital syndrome, and its connection with the problem of the reaction of the body to injurious agents ("alarm reaction" of Selye), The Harvey Lecture Series, 1942-1943, xxxviii, 123-186. Google Scholar3. ALBRIGHTBURNETTPARSONREIFENSTEINROOS FCHWECA: Osteomalacia and late rickets: the various etiologies met in the United States with emphasis on that resulting from a specific form of renal acidosis, the therapeutic indications for each etiological sub-group, and the relationship between osteomalacia and Milkman's syndrome, Medicine, 1946, xxv, 399-479. Google Scholar4. ALBRIGHT F: The effect of hormones on osteogenesis in man, Recent Progress in Hormone Research: Proceedings of the Laurentian Conference, 1947, i, 293-353. Google Scholar5. REIFENSTEINALBRIGHT ECF: The metabolic effects of steroid hormones in osteoporosis, Jr. Clin. Invest., 1947, xxvi, 24-56. CrossrefGoogle Scholar6. REIFENSTEINALBRIGHTWELLS ECFSL: The accumulation, interpretation, and presentation of data pertaining to metabolic balances, notably those of calcium, phosphorus, and nitrogen, Jr. Clin. Endocrinol., 1945, v, 367-395. CrossrefGoogle Scholar7. ALBRIGHTBURNETTCOPEPARSON FCHOW: Acute atrophy of bone (osteoporosis) simulating hyperparathyroidism, Jr. Clin. Endocrinol., 1941, i, 711-716. CrossrefGoogle Scholar8. ALBRIGHTSMITHFRASER FPHR: A syndrome characterized by primary ovarian insufficiency and decreased stature: report of 11 cases with a digression on hormonal control of axillary and pubic hair, Am. Jr. Med. Sci., 1942, cciv, 625-648. CrossrefGoogle Scholar9. SELYE H: The general adaptation syndrome and the diseases of adaptation, Jr. Clin. Endocrinol., 1946, vi, 117-230. CrossrefGoogle Scholar10. TALBOTSALTZMANWIXOMWOLFE NBAHRLJK: The colorimetric assay of urinary corticosteroid-like substances, Jr. Biol. Chem., 1945, clx, 535-546. CrossrefGoogle Scholar11. DEMPSEY EW: Personal communication. Google Scholar12. VENNINGBROWNE EHJS: Conference on Metabolic Aspects of Convalescence, Fourteenth Meeting, Nov. 12-13, 1946, New York, 186-187. Google Scholar13. TALBOTALBRIGHTSALTZMANZYGMUNTOWICZWIXOM NBFAHAR: The excretion of 11-oxycorticosteroid-like substances by normal and abnormal subjects (In press). Jr. Clin. Endocrinol., 1947, vii, 331-350. CrossrefGoogle Scholar14. EMERSONBECKMAN KWW: Calcium metabolism in nephrosis; I. a description of an abnormality in calcium metabolism in children with nephrosis, Jr. Clin. Invest., 1945, xxiv, 564-572. CrossrefGoogle Scholar15. FORBESALBRIGHTREIFENSTEINBRYANTCOXDEMPSEY APFECDFLDEF: Studies on the fate of intravenously administered plasma protein (Submitted for publication). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*The John Phillips Memorial Lecture read before the American College of Physicians in Chicago on April 30, 1947. For further studies by the author and his colleagues on the subject of osteoporosis the reader is referred to the following references in the bibliography.1, 2, 3, 4, 5, 6, 7From the Medical Service of the Massachusetts General Hospital and the Department of Medicine of the Harvard Medical School, Boston, Massachusetts.The expense of these studies was partly defrayed by grants from the Josiah Macy, Jr. Foundation, the Rockefeller Foundation, the National Advisory Cancer Council, Ayerst, McKenna and Harrison, Ltd., and the American Cancer Society on the recommendation of the Committee on Growth of the National Research Council. A bed supported by the Mallinckrodt Chemical Company on the Metabolic Ward was used for part of these studies.The part of this address which has to do with internal skeletal dynamics and osteoporosis of old age was read at the Ether Centenary at the Massachusetts General Hospital on October 14, 1946. 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Remodeling SequencePerturbations of hypothalamic-pituitary-gonadal (HPG) axis and adrenal androgen (AA) functions in rheumatoid arthritisCasodex (a nonsteroidal antiandrogen) reduces cancellous, endosteal, and periosteal bone formation in estrogen-replete female ratsInfluence of small doses of dehydroepiandroster-one on the inception of the hormonal function of testes of sexually immature monkeysAdrenarche does not occur in treated patients with congenital adrenal hyperplasia resulting from 21-hydroxylase deficiencyAbnormalities in adrenal androgens, but not of glucocorticoids, in early Alzheimer's diseaseFamilial influences on the adrenal androgen excretion rate during the adrenarcheBone mineral content of the third lumbar vertebra during 18 months of prednisolone treatment for giant cell arteritisManagement of Menopause, Including Hormonal Replacement TherapyTestosterone Deficiency As a Risk Factor for Hip Fractures in Men: A Case-Control StudyRecurrent Cushing's disease with low 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THOMSON, M.D., BOY FRAME, M.D., F.A.C.P.A simple method for the assay of eight steroids in small volumes of plasmaExogenous estrogens and endometrial cancerObservations on the Natural History of AtherogenesisAllgemeine Radiologie und Morphologie der KnochenkrankheitenInvolutional (Physiologic) Bone Loss in Women and the Feasibility of Preventing Structural Failure*Optimal Calcium Therapy: A Method Affording Subjective and Objective ImprovementsEffects of cortisone on bone metabolism in intact and thyroidectomized rabbitsThe Prepuberal and Puberal Growth of the Adrenal (Adrenarche)Osteoporotic MechanismsErbliche Fehlbildungen und Anomalien des SkeletesRadiology of OsteoporosisEstrogens in the Menopause and PostmenopauseEffect of hydrocortisone and gonadal hormones on growing rabbit boneOsteogenesis imperfectaCalciolysis as the initial stage of bone resorptionThe effect of the interaction of dietary protein and calcium on the growth and maintenance of the bones of young, adult and aged ratsEffects of androgens, estrogens and high calcium intakes on bone formation and resorption in osteoporosisA study of bone resorption and the ?osteoclast? problem by stain historadiographyOsteoporosis: A Review of Pathogenesis and TreatmentJACOB BASSAN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD FROST, M.D.Corticosteroid Osteoporosis and Treatment with Anabolic HormoneObservations on the incidence, aetiology, and pathology of senile osteoporosisAllgemeine Pathologie des exogenen quantitativen NahrungsmangelsLiver diseases and osteoporosis in childrenDisabling fractures in the agedBONE CHANGES ASSOCIATED WITH CORTISONE ADMINISTRATION IN THE RAT : CONVERSION OF 'RICKETS' TO 'OSTEOPOROSIS'OSTEOPOROSIS: A HARD LOOKSENILE OSTEOPOROSIS: TREATMENT WITH A STEROID HORMONE COMBINATIONON THE INCIDENCE OF SENILE OSTEOPOROSIS*RICHMOND W. SMITH JR., M.D., WILLIAM R. EYLER, M.D., RAYMOND C. MELLINGER, M.D.Steroid Osteoporosis [ Abridged ]General pathology of the musculo-skeletal systemDie Klinik des KlimakteriumsThe Effects of Stress on the Periodontium of the Syrian HamsterCURRENT CONCEPTS IN THE MANAGEMENT OF OSTEOPOROSISSteroid Hormones and the Aging SkeletonDer Hyperparathyreoidismus unter besonderer Berücksichtigung der Ostitis fibrosa generalisata (Recklinghausen)Sex steroid influence on the aging processA COMPARATIVE RADIOLOGICAL STUDY OF CALCIFIED ATHEROMA IN MALES AND FEMALES OVER 50 YEARS OF AGEOsteoporosis in lambs in a lead mining areaDer Einfluß der Parotisdrüsen auf den StoffwechselThe MenopauseSteroid Hormones in OsteoporosisDiscussion on OsteoporosisOSTEOPOROSISSchleichende Spontanfrakturen und renale OsteopathieADRENOCORTICAL CAPACITY AND THE METABOLISM OF CORTISOL IN ELDERLY PATIENTS†Vitamin D Resistant OsteomalaciaDie Wirkungen der Sexualhormone auf das Skelet und den SkeletstoffwechselKlinik und Therapie der HodeninsuffizienzÜber den Einfluß der androgenen Hormone auf die Verknöcherung des KehlkopfskeletsSENILE CHANGES OF THE SKIN IN MANSteroid hormones and periodontal diseasesOsteoporosis, Hypercalcemia and Nephropathy following Immobilization of Children.Ein Beitrag zur Problematik und R�ntgendiagnostik prim�rer AmenorrhoenTHREE CALCIUM TOLERANCE TEST IN SENILE OSTEOPOROSIS*,†The Etiology of Periodontal DiseaseThe Effect of the Systemic Administration of Cortisone Upon the Periodontium of White MiceIron equilibriumMedical conditions complicating oral surgeryCalcium and Phosphorus MetabolismSome Current Aspects of NutritionOsteoporosis and Pathological Fractures Following Treatment with Acth and CortisoneAntibiotics and Fungous Infections1THE ENCEPHALOPATHY OF HYPERINSULINISM*S. K. FINEBERG, M.D., ALEXANDER ALTSCHUL, M.D., F.A.C.P.The influence of the endocrine glands on the development of the childExperimental Evidence of Systemic Influence on the Development of Periodontal DiseaseProtein deprivation and the periodontal structures of the albino ratDiscussion on the Problems of Old AgePhysiology of the Adrenal CortexKlinisches Bild, Entstehung und heutige Bedeutung der universellen calcipriven OsteopathienRole of the neurohypophysis in the pathogenesis of hypertension and some allied disorders associated with agingChemotherapy of malignant diseaseClinical Endocrinology and the Cancer ProblemBone pathology as it relates to some phases of oral surgery 1 December 1947Volume 27, Issue 6Page: 861-882KeywordsAdrenal cortexHospital medicineMedical servicesOsteoporosisSyphilis Issue Published: 1 December 1947 Copyright & PermissionsCopyright, 1947, by The American College of PhysiciansPDF downloadLoading ...