tbuckley/cabot-search huggingface dataset:
British Photodermatology Group
Authors: A Fityan, H Fassihi, D Mcgibbon, R Sarkany, D Koumaki, A Haylett, T Farrar, L Ling
Journal: British Journal of Dermatology (2015)

Solar urticaria (SU) is a rare photodermatosis that presents with erythema, itching and wealing within minutes of exposure to light.The underlying mechanism is thought to operate through IgE degranulation of mast cells following recognition of an as yet unidentified chromophore.The largest study of SU to date demonstrated a median age of onset of 35 years (range 3-85) (Beattie PE, Dawe RS, Ibbotson SH, Ferguson J. Characteristics and prognosis of idiopathic solar urticaria: a cohort of 87 cases.Arch Dermatol 2003; 139: 1149-54).To our knowledge, only one further reported case of paediatric SU can be found in the literature (Harris A, Burge SM, George SA.Solar urticaria in an infant.Br J Dermatol 1997; 136: 105-7).We report five cases of SU arising in children, along with the clinical features, investigations and our experience in their management.The mean age of onset was 10.4 months (range 1-24); four patients were male.Comorbidities included eczema with associated food allergies, neurofibromatosis type 1 and neonatal jaundice.Otherwise the patients demonstrated no developmental delay or evidence of underlying disease.Aside from lactulose in one child, no other medications/supplements were reported.The onset of the rash was after 2-10 min in 80% of the children, with the remaining child requiring up to 30 min of exposure to trigger the rash.The same patient had a longer offset (4-12 h), compared with a mean 79 min (range 30-120) in the other children.The reported rashes were similar to those seen in adults, with erythema, weals and evidence of pruritus.A papular erythema was reported in one child, and in another, one episode of purpura was described alongside typical urticaria at other sites.In two patients there was a history of light-induced angiooedema, with sneezing, epiphora and floppiness affecting one patient.Monochromator testing was performed on all five patients.Three of the patients demonstrated an immediate erythema, weal or flare; one patient demonstrated a delayed onset of erythema at 4 h, clearing within 12 h (although the history was of a quicker onset and offset); the fifth had normal results.Sensitivity was in the range 400-600 nm, with all patients exhibiting sensitivity at 500 nm.All patients screened negative for porphyria.One of the five patients' symptoms spontaneously resolved by the age of 3 years.Among the remaining four patients, nonsedating antihistamines in combination with photoprotection were effective in three cases; in the final case high-dose antihistamines and the leukotriene antagonist, montelukast, were ineffective.In conclusion, SU appears to be more common in childhood than previously reported.Importantly, it appears to demonstrate similar clinical features and response to treatment to SU in adults.
Infectious Mononucleosis
Authors: Elizabeth Uhlmann Neel
Journal: JAMA (1976)

Infectious mononucleosis (IM) is usually considered a benign disease. Agranulocytosis developed in a young college student 14 days after the onset of IM. Fulminant staphylococcal pneumonia and bilateral pulmonary infarcts resulted, and the patient died 4 1/2 hours after admission to a hospital. Agranulocytosis secondary to IM may be more prevalent than previously thought. A review of the literature indicated that infection developed in 57.9% of the patients with IM and extreme neutropenia and 45.4% of the infected patients died. (<i>JAMA</i>236:1493-1494, 1976)
Fetal malformation after Debendox treatment in early pregnancy.
Authors: J Monson, Peter Richards
Journal: BMJ (1978)

Results of desmopressin urine concentration test at different ages Age group No of subjects Mean maximum (years) osmolality (mmol/kg) ± SD (A) 20-24 7 1044±73 (B) 25-29 3 983 ±48 (C) 30-34 3 983 ±152 (D) 35-39 6 935 ±82 (E) 40-44 8 894 ±95 (F) 45-49 3 926 ±143 (G) 50-54 8 873 ±142 (H) 55-59 5 909±91patients aged 40-59 (864 i 164 mmol/kg).Thus although all subjects achieved a concentration which we would regard as normal our results suggest that urine-concentrating ability diminishes with advancing age.We have found no evidence of diminished ability as a consequence of various non-renal diseases.
THE THERAPY OF THE COOK COUNTY HOSPITAL
Authors: BERNARD FANTUS
Journal: JAMA (1934)

<h3>THERAPY OF GLAUCOMA</h3> Outline by Sanford R. Giffford, M.D. <h3>Definition.—</h3> A sufficient increase in intra-ocular tension to damage the contents of the eyeball. Differentiation must be made between (<i>a</i>) Acute primary glaucoma, (<i>b</i>) chronic primary glaucoma, (<i>c</i>) secondary glaucoma and (<i>d</i>) absolute glaucoma. <h3>Diagnosis.—</h3> The tonometer and the perimeter must be used as a routine whenever there is even a suspicion of glaucoma, which arises when in a person over 40 years of age there occurs a sudden failure in the amplitude of accommodation, a temporary loss of some or all vision, hazy or foggy vision, or the appearance of colored halos around artificial lights. In the normal eye the tension is between 15 and 25 mm. of mercury as measured by the tonometer (Schiötz). <h3>ACUTE GLAUCOMA</h3> Acute glaucoma is an emergency condition, most commonly arising during the latter part of the night with severe pain in the head, possibly
Medical education toward the 21st century
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The article "A Crisis in Medical Education"<sup>1</sup>raises critical issues. Clinical education must compete with the demands of peer review organizations, diagnosis-related groups, and other cost constraints. The hospital patient population and the length of hospital stay are changing, yet the goals of preparing future physicians for excellence in practice and compassion in the caring of patients remain the same. New approaches to the medical curriculum are needed. As patient care is shifted from in-hospital ward care to alternative care, we should consider teaching students in other clinical settings as well. At Mount Sinai Medical School, there is a pilot program in teaching medical students in the setting of the attending physicians' private offices. A day center in the hospital, where patients will receive diagnostic studies during the day and then be discharged, is being evaluated. The role of students in these alternative facilities should be
Genital and abdominal self-surgery. A case report
Authors: N. H. Kalin
Journal: JAMA (1979)

In two separate procedures, a psychiatric patient first performed a bilateral orchiectomy on himself and then later attempted to denervate his adrenal glands. This case suggests that physicians should be alerted to the possibility of self-surgery occurring in patients who have sought elective surgery and have been rejected. (<i>JAMA</i>241:2188-2189, 1979)
Interventions for the Treatment, Management and Rehabilitation of Patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis: An Updated Systematic Review
Authors: Duncan Chambers, Anne-Marie Bagnall, Susanne Hempel, Carol Forbes
Journal: Journal of the Royal Society of Medicine (2006)

To determine whether any particular intervention or combination of interventions is effective in the treatment, management and rehabilitation of adults and children with a diagnosis of chronic fatigue syndrome / myalgic encephalomyelitis (CFS/ME).Substantive update of a systematic review published in 2002. Randomized (RCTs) and non-randomized controlled trials of any intervention or combination of interventions were eligible for inclusion. Study participants could be adults or children with a diagnosis of CFS/ME based on any criteria. We searched eleven electronic databases, reference lists of articles and reviews, and textbooks on CFS/ME. Additional references were sought by contact with experts.Seventy studies met the inclusion criteria. Studies on behavioural, immunological, pharmacological and complementary therapies, nutritional supplements and miscellaneous other interventions were identified. Graded exercise therapy and cognitive behaviour therapy appeared to reduce symptoms and improve function based on evidence from RCTs. For most other interventions, evidence of effectiveness was inconclusive and some interventions were associated with significant adverse effects.Over the last five years, there has been a marked increase in the size and quality of the evidence base on interventions for CFS/ME. Some behavioural interventions have shown promising results in reducing the symptoms of CFS/ME and improving physical functioning. There is a need for research to define the characteristics of patients who would benefit from specific interventions and to develop clinically relevant objective outcome measures.
POST OFFICE MEDICAL OFFICERS: THEIR OPPORTUNITY FOR JUSTICE
Journal: BMJ (1912)

MARCHl 2, I912,to decide who was lying; they certainly suggest to my mind that it was not Sir Watson Cheyne nor myself.Such, Sir, is a plain unvarnished tale of the inception and execution of tne idea of thc Queen's Hall meeting, and I deny indignantly that from first to last politics had any- thing to do with the matter.Far different is it with the action of the Council, for I
THE EFFECT OF THE ENTRANCE OF AIR INTO THE VEINS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Body fat distribution and 5-year risk of death in older women
Authors: A. R. Folsom
Journal: JAMA (1993)

<h3>Objective.</h3> —To test the hypothesis that both body mass index (expressed as the ratio of weight in kilograms per height in meters squared) and the ratio of waist circumference to hip circumference are positively associated with mortality risk in older women. <h3>Design.</h3> —Prospective cohort study with a 5-year follow-up period. <h3>Setting.</h3> —General community. <h3>Participants.</h3> —Random sample of 41 837 Iowa women aged 55 to 69 years. <h3>Main Outcome Measure.</h3> —Total mortality (1504 deaths). <h3>Main Results.</h3> —Body mass index, an index of relative weight, was associated with mortality in a J-shaped fashion: rates were elevated in the leanest as well as in the most obese women. In contrast, waist/hip circumference ratio was strongly and positively associated with mortality in a dose-response manner. Adjusted for age, body mass index, smoking, education level, marital status, estrogen use, and alcohol use, a 0.15-unit increase in waist/hip circumference ratio (eg, a 15-cm [6-in] increase in waist measurement in a woman with 100-cm [40-in] hips) was associated with a 60% greater relative risk of death. The observed associations were not explained to any great degree by bias from weight loss prior to baseline or higher early deaths among lean participants. <h3>Conclusions.</h3> —Waist/hip circumference ratio is a better marker than body mass index of risk of death in older women. Waist/hip circumference ratio should be measured as part of routine surveillance and risk monitoring in medical practice. <i>JAMA</i>. 1993;269:483-487)
Clinical Handbook of Psychiatry and the Law
Authors: Manuel P. Pardo
Journal: JAMA (1991)

In 1982 the authors published the first edition of their book, which received the Manfred Guttmacher Award of the American Psychiatric Association and the American Academy of Psychiatry and the Law for "outstanding contribution to the literature of forensic psychiatry." Nearly a decade later, new developments in the forensic arena as it applies to psychiatric practice have made it necessary to undertake major updating. The authors accomplished this within the original format of using case examples to open each chapter. Many new case examples were added. The development of child psychiatry and the law as a subspecialty in its own right is given recognition in this edition. Other issues in the book relate to failure to protect victims of patients' violence, rights to refuse antipsychotic medication, responsibility for causing tardive dyskinesia and other drug-related complications, confidentiality and third-party reviewers, and other problems confronting mental health practitioners in their everyday practice.
Aluminum and Renal Osteodystrophy
Authors: H. Nebeker
Journal: Annual Review of Medicine (1986)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More
Clinical Physiology.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemolytic Anemia and Venous Gangrene
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sixty-Eighth Annual Meeting of the American Radium Society
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Sixty-Eighth Annual Meeting of the American Radium Society Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 4, October 1985, Page 800, https://doi.org/10.1093/jnci/75.4.800-a Published: 01 October 1985
Doc: Facts, Fables and Foibles.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Convalescent
Authors: M. Therese Southgate
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cinacalcet for Cardiovascular Disease in Patients Undergoing Dialysis
Authors: Cecilia Söderberg-Nauclér
Journal: New England Journal of Medicine (2013)

correctionand their median overall survival was 30.1 months (P<0.001) (Fig. 1B).The survival rate was highest among 25 patients who received continuous valganciclovir treatment after the first 6 months, with a 2-year survival rate of 90% and median overall survival of 56.4 months (P<0.001) (Fig. 1C).It is unlikely that any bias in patient selection could have resulted in these high rates of survival.
A head‐to‐head comparison of ixekizumab vs. guselkumab in patients with moderate‐to‐severe plaque psoriasis: 24‐week efficacy and safety results from a randomized, double‐blinded trial*
Authors: A. Blauvelt, C. Leonardi, B. Elewski, J.J. Crowley, L.C. Guenther, M. Gooderham, R.G. Langley, R. Vender, A. Pinter, C.E.M. Griffiths, Y. Tada, H. Elmaraghy, R.G. Lima, G. Gallo, L. Renda, R. Burge, S.Y. Park, B. Zhu, K. Papp
Journal: British Journal of Dermatology (2020)

Significantly more patients with moderate‐to‐severe plaque psoriasis treated with the interleukin (IL)‐17A inhibitor ixekizumab vs. the IL‐23p19 inhibitor guselkumab in the IXORA‐R head‐to‐head trial achieved 100% improvement in Psoriasis Area and Severity Index (PASI 100) at week 12. To compare skin and nail clearance and patient‐reported outcomes for ixekizumab vs. guselkumab, up to week 24. IXORA‐R enrolled adults with moderate‐to‐severe plaque psoriasis, defined as static Physician's Global Assessment ≥ 3, PASI ≥ 12 and involved body surface area ≥ 10%. Statistical comparisons were performed using the Cochran–Mantel–Haenszel test stratified by pooled site. Time‐to‐first‐event comparisons were performed using Kaplan–Meier analysis, and P‐values were generated using adjusted log‐rank tests stratified by treatment group. Cumulative days at clinical and patient‐reported responses were compared by ancova. The trial was registered with ClinicalTrials.gov (NCT03573323). Of the 1027 patients randomly assigned, 90% completed the trial (465 of 520 ixekizumab and 459 of 507 guselkumab). As early as week 2 and through week 16, more patients on ixekizumab achieved PASI 100 (P < 0·01). At week 24, ixekizumab was noninferior to guselkumab (50% vs. 52%, difference −2·3%), with no statistically significant difference in PASI 100 (P = 0·41). More patients receiving ixekizumab showed completely clear nails at week 24 (52% vs. 31%, P = 0·007). The median time to first PASI 50/75/90 and PASI 100 were 2 and 7·5 weeks shorter, respectively, for patients on ixekizumab vs. guselkumab (P < 0·001). Patients on ixekizumab also had a greater cumulative benefit, with more days at PASI 90 and 100, with Dermatology Life Quality Index of 0 or 1, and itch free (P < 0·05). The frequency of serious adverse events was 3% for each group, with no new safety signals. Ixekizumab was noninferior to guselkumab in complete skin clearance and superior in clearing nails at week 24. Ixekizumab cleared skin more rapidly in patients with moderate‐to‐severe plaque psoriasis, with a greater cumulative benefit, than guselkumab. Overall, the safety findings were consistent with the known safety profile for ixekizumab.
Waiting Times for Treatment of Rectal Cancer in North West England
Authors: SE Duff, C Wood, V McCredie, E Levine, MP Saunders, ST O'Dwyer
Journal: Journal of the Royal Society of Medicine (2004)

An interim goal of the NHS National Cancer Plan is that, by 2005, patients with cancer should be treated within one month of diagnosis and within two months from urgent general practitioner referral. Preoperative radiotherapy for rectal cancer reduces the risk of local recurrence and may translate into improved patient survival. We conducted a prospective audit of existing waiting times for preoperative radiotherapy experienced by 65 patients with rectal cancer referred to the Christie Cancer Centre, Manchester, UK, between May and November 2002. The median time between referral from the surgeon to the start of radiotherapy was 40 days (range 11-85). Only 4 patients (6%) received radiotherapy within 28 days of referral by the surgeon. 62 patients (95%) underwent surgery within 14 days of completing radiotherapy. Delays in the provision of preoperative radiotherapy were primarily due to shortages of radiography staff and equipment. Lack of such infrastructure will prove a major stumbling block to achieving the targets of the NHS Cancer Plan.
Real Life Efficacy and Safety of Rivaroxaban for Acute VTE Treatment – First Results of the Prospective Noac Registry (NCT01588119)
Authors: Vera Gelbricht, Christina Koehler, Sebastian Werth, Ulrike Haensel, Thomas Schreier, Maria Eulitz, Luise Tittl, Ines Beyer-Westendorf, Jan Beyer-Westendorf
Journal: Blood (2012)