tbuckley/cabot-search huggingface dataset:
Predictors of tumor progression during neoadjuvant chemotherapy in breast cancer
Authors: A. S. Caudle, A. M. Gonzalez-Angulo, H. K. Kelly, P. Liu, L. Pusztai, W. F. Symmans, H. M. Kuerer, E. A. Mittendorf, G. N. Hortobagyi, F. Meric-Bernstam
Journal: Journal of Clinical Oncology (2009)

603 Background: While most patients with breast cancer receiving neoadjuvant chemotherapy (NCT) have some tumor response, a small proportion progress during therapy. Although several groups have looked at markers for response, none have specifically evaluated markers for progression. The goal of this study was to identify predictors of tumor progression during NCT with the ultimate aim of identifying the subset of patients who may benefit from a first-line surgical approach. Methods: Patients with stage I-III breast cancer treated at a single comprehensive cancer center with NCT between 1994 and 2007 were included. Data was obtained from a review of medical records of patients in a prospectively acquired database. Chemotherapy consisted of anthracycline and/or taxane-based regimens. Statistical analysis was performed using univariate and multivariate analysis with logistic regression analyzing patients with some response or stable disease versus patients with progression. Results: 1928 patients received NCT: 1762 (91%) had some response (minor, partial, or complete), 107 (6%) had stable disease (SD), and 59 (3%) progressed (PD) on at least one NCT regimen. Clinical factors that correlate with PD in univariate analysis include presenting T (T3 vs T1, p = 0.002) and AJCC stage (stage IIIb/IIIc vs I/II/III, p = 0.02). Predictive histopathological features were high tumor grade (p = 0.005), high Ki-67 (p = 0.002), and negative ER and PR status (p &lt; 0.0001 and p = 0.0006). Patients with PD were more likely to be treated with a taxane (79% vs 88%, p = 0.04). In the post-NCT surgical specimens, patients with PD were more likely to have higher T stage (p &lt; 0.0001), lymph node metastasis (p = 0.01), and lymphovascular invasion (p = 0.02). On multivariate analysis, pre-NCT T status and ER status were the most important predictors of progression. Conclusions: Pre-treatment characteristics predictive of disease progression on NCT include advanced tumors, high tumor grade, high Ki-67, and negative ER or PR status. Since high grade and negative ER/PR status have also been associated with a complete pathologic response to NCT, there is a clear need for more specific molecular predictors of response and progression in order to select appropriate treatment in these patients. No significant financial relationships to disclose.
Pheochromocytoma of the urinary bladder. Systemic hemodynamics and circulating catecholamine levels
Authors: F. H. Messerli
Journal: JAMA (1982)

PHEOCHROMOCYTOMA is an uncommon lesion of the urinary bladder, accounting for less than 0.06% of all vesical tumors.<sup>1</sup>However, its classic symptoms—sharp headaches, hypertension, and fainting immediately after voiding—often present a diagnostic puzzle, especially since the entity is not widely known.<sup>2,3</sup>The present report describes a patient with both normal resting BP and 24-hour urinary catecholamine levels, in whom systemic hemodynamics and plasma catecholamine levels were measured before and after voiding. <h3>Report of a Case</h3> A 38-year-old man was admitted to the hospital for evaluation of piercing headaches, which lasted a few minutes and occurred immediately after emptying the bladder. This symptom had been present for about a year. The patient turned pallid and sweated profusely during these episodes and felt as though he was going to pass out. To avoid the symptoms, the patient preferred to empty his bladder only partially. Medical history was not significant, but
Abstract 5253: Regulation of estrogen related receptor α by ING4 and its potential role in breast cancer pathogenesis
Authors: Aymen A. Shatnawi, Vincent Giguere
Journal: Cancer Research (2019)

Abstract Breast cancer is one of the most frequently diagnosed tumors in the United States that affects one in eight women during their lifetime. It is second only to lung cancer as cause of cancer death in women. The orphan members of the nuclear receptor superfamily, estrogen-related receptors ERRα and γ (ERRs) isoforms are considered the master regulators of energy metabolism and their transcriptional pathways are highly associated with the cancer phenotype. Realizing the important function of co-regulators on ERRs transcriptional activity and their impact on cancer development and progression, we have identified the tumor growth family member 4 (ING4), a protein that has been implicated in several solid tumors and physically interacts with ERRα in breast cancer cellular models and modulates its transcriptional activity. Examination of the Oncomine database revealed that both ING4 and ERRα gene expression were significantly higher in invasive ductal and lobular breast carcinomas compared to normal ones, and their increased expression is inversely correlated with the overall patient survival rate in The Cancer Genome Atlas (TCGA) database. Knocking down ING4 in a breast cancer cell line using siRNA technology significantly decreased the expression of ERRα, and overexpression of ING4 upregulates the endogenous expression of ERRα. Well-defined ERRα target genes were also regulated by ING4 in the same manner as ERRα. Also, depleting ING4 expression significantly increased breast cancer cell migration in in vitro scratch assays, while both ING4 and ERRα knockdown decreased breast cancer cell proliferation. Collectively, these findings provide evidence for positive regulation of ERRα by ING4. Understanding the mechanism by which ING4/ERRα interaction regulates cellular pathways in breast cancer, underscores the impact of such regulation on biological and pharmacological actions. Thus, they can be used for the development of improved novel pharmaceuticals that target ERRα/ING4 complex or its downstream pathways. Citation Format: Aymen A. Shatnawi, Vincent Giguere. Regulation of estrogen related receptor α by ING4 and its potential role in breast cancer pathogenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5253.
Errors in Table and Supplemental Figure
Authors: Katharine Harding, Emma Tallantyre, Neil Robertson
Journal: JAMA Neurology (2019)

Martina Absinta, MD, PhD; Pascal Sati, PhD; Federica Masuzzo, MD; Govind Nair, PhD; Varun Sethi, MD, PhD; Hadar Kolb, MD; Joan Ohayon, CRNP; Tianxia Wu, PhD; Irene C. M. Cortese, MD; Daniel S. Reich, MD, PhD
Effect of Ethamivan on Alveolar Ventilation in Patients with Chronic Lung Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Administration of Most Closely HLA-Matched Multivirus-Specific T Cells for the Treatment of EBV, CMV, AdV, HHV6, and BKV Post Allogeneic Hematopoietic Stem Cell Transplant
Authors: Bilal Omer, Anastasia Papadopoulou, Nikita Koottiyaniyil, Adrian P. Gee, Swati Naik, Caridad Marinez, Leung Kathryn, Ghadir S. Sasa, Robert A. Krance, Bambi Grilley, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, Ann M. Leen, Ifigeneia Tzannou
Journal: Blood (2015)
Rubella Antibody Persistence After Immunization
Authors: Susan Y. Chu
Journal: JAMA (1988)

A comparative field trial of three rubella virus vaccines (Cendehill, HPV-77 DE-5, and HPV-77 DK-12) was initiated in 1969 on the islands of Kauai and Hawaii in the state of Hawaii. In 1985, follow-up was reinitiated to assess the long-term durability of vaccine-induced immunity. Enzyme-linked immunosorbent assays of serum specimens from 1290 participants demonstrated seropositive rates of 92.4% and 96.4% at screening levels of 10 (protective level) and 7 (lowest detectable level) IU/mL, respectively. The seropositive rates were not related to reinfection or reimmunizations. These findings indicate that vaccine-induced rubella antibodies are detectable in almost all persons up to 16 years after successful vaccination. (<i>JAMA</i>1988;259:3133-3136)
Suicide by physicians on probation
Authors: G. E. Murphy
Journal: JAMA (1981)

<h3>In Reply.—</h3> Comments in my communication alluding to Drs Banta and Thacker relate to reports in the Washington<i>Daily News</i>and other media after news release of their views of EFM based on "their extensive review of the literature." Opinions I express are the result of my involvement in the development and use of EFM since its inception nearly two decades ago. The list of references submitted by Banta and Thacker contains articles (1,4,5,6) that had not yet been published when my article was written or included among 253 references cited in a report of the National Institute of Child Health and Human Development Consensus Conference on Antenatal Diagnosis (March 1979). Drs Banta and Thacker failed to refer to the detailed critique of their unpublished manuscript, "Costs and Benefits of EFM: A review of the literature." That article is reviewed in depth in "The Fetal Monitoring Debate" (<i>Obstet Gynecol</i>1979;54:103-109).
Wrong Temperature and Misspelled Name
Journal: JAMA (1981)

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Light Therapeutics.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manual of Organic Materia Medica.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized Clinical Study of Thiopental Loading in Comatose Survivors of Cardiac Arrest
Journal: New England Journal of Medicine (1986)

After restoration of spontaneous circulation and adequate oxygenation, 262 comatose survivors of cardiac arrest were randomly assigned to receive standard brain-oriented intensive care or the same standard therapy plus a single intravenous loading dose of thiopental (30 mg per kilogram of body weight). The study was designed to have an 80 percent probability of detecting a 20 percent reduction in the incidence of permanent postischemic cerebral dysfunction. Base-line characteristics were similar in the two treatment groups. At the end of one year of follow-up, there was no statistically significant difference between treatment groups in the proportion of patients who died (77 percent of the thiopental vs. 80 percent of the standard-therapy group), survived with "good" cerebral recovery (20 percent of the thiopental vs. 15 percent of the standard-therapy group), or survived with permanent severe neurologic damage (2 percent of the thiopental vs. 5 percent of the standard-therapy group). The results of this study do not support the use of thiopental for brain resuscitation after cardiac arrest. (N Engl J Med 1986; 314:397–403.)
Correction
Journal: Circulation (2012)

an error occurred.On page 2471, in the second paragraph of Cardiac Catheterization and Blood Sampling, the sentence reads "At the beginning of the cardiac catheterizations, we collected blood samples before the injection of heparin."It should read "At the beginning of the cardiac catheterizations, we collected blood samples after the establishment of arterial blood access with heparinized saline flush and before the injection of 2,000 IU heparin as a routine dose for cardiac catheterization."The error has been corrected in the current online version of the article.The authors regret the error.
Abstract 4281: Oncostatin M renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-fluorouracil by inducing hepatocytic differentiation
Authors: Taro Yamashita, Masao Honda, Kouki Nio, Shuichi Kaneko
Journal: Cancer Research (2010)

Abstract Recent evidence suggests that a certain type of hepatocellular carcinoma (HCC) is hierarchically organized by a subset of cells with stem cell features (cancer stem cells: CSCs). Although normal stem cells and cancer stem cells (CSCs) are considered to share similar self-renewal programs, it is uncertain whether differentiation signaling is kept maintained in both types of cells. In this study, we investigated the effect of oncostatin M (OSM), an interleukin 6-related cytokine known to induce the differentiation of hepatoblasts into hepatocytes, on liver CSCs. Recombinant human OSM was used for both in vitro and in vivo experiments. Epithelial cell adhesion molecule (EpCAM) was used for the isolation of liver CSCs. Gene and protein expression was evaluated by quantitative reverse transcription-PCR, immunohistochemistry, and intracellular fluorescence-activated cell sorting. Apoptosis was evaluated by Annexin V and activated-caspase 3 staining. Tumor initiating capability was examined by the subcutaneous tumor formation in NOD/SCID mice. OSM receptor expression was detected in the majority of EpCAM-positive (EpCAM+) HCC with stem/progenitor cell features. OSM treatment (100 ng/ml) resulted in the induction of hepatocytic differentiation of EpCAM+ liver CSCs derived from hepatocellular carcinoma (HCC) cell lines and primary HCCs, in terms of decrease of alpha-fetoprotein and cytokeratin 19 production and increase of albumin production. Furthermore, OSM treated cells exhibited reduced expression of stemness-related genes including Bmi1 and POU5F1. While pretreatment of HCC cell lines with OSM before transplantation in vitro resulted in the decreased tumorigenic capacity, the OSM treatment after transplantation in vivo showed small tumor suppressing effects irrespective of hepatocytic differentiation of the tumor. Intriguingly, when the OSM treatment was combined with chemotherapeutic reagent 5-fluorouracil to eradicate non-CSCs, we observed the dramatic increase of apoptotic cells in vitro and the suppression of tumorigenesis in vivo compared with either OSM or 5-fluorouracil treatment alone. In conclusion, our data suggest that OSM can be effectively utilized for the differentiation and active cell division of dormant EpCAM+ liver CSCs, and the combination of OSM and conventional chemotherapy such as 5-fluorouracil efficiently eliminates HCC by targeting both CSCs and non-CSCs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4281.
INDUCED PARKINSONISM
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the Causes of Unavoidable Haemorrhage during Miscarriage or Labour when the Placenta is Praevia
Authors: J. M. Duncan
Journal: BMJ (1873)

connected witlh the anterior and upper part of the transverse part of the arch of the aorta, anid projecting forwards in front of the innominate artery and the left carotid-the left subclavian apparently coming off immiiediately to the left of the sac itself.The sac extended forwards
Blood cultures drawn through catheters
Authors: H. H. Handsfield
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Letter.
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
West Nile Virus Activity—Eastern United States, 2001
Journal: JAMA (2001)

In 2000, ArboNET, an enhanced human and animal surveillance system designed to monitor the geographic spread of West Nile virus (WNV) in the United States and to identify areas at increased risk for human infections with WNV, detected WNV activity in the District of Columbia and 12 states. This system, first implemented in the District of Columbia and 20 states along the Atlantic and Gulf coasts, was later expanded throughout the continental United States. This report summarizes ArboNET data from January 1 through July 25, 2001, which documents epizootic WNV activity in the southeast and indicates the need for widespread implementation of WNV prevention activities.