tbuckley/cabot-search huggingface dataset:
Emergency Psychiatry
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POLIENCEPHALOMYELITIS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency Department Surveillance for Weapon-Related Injuries—Massachusetts, November 1993-April 1994
Journal: JAMA (1995)

During 1992, a total of 37,776 firearm-related deaths occurred in the United States (1), and in 1991, firearm-related deaths were the leading or second leading cause of injury death in 15 states (2). Because of limitations in data, however, the epidemiology of nonfatal firearm- and other weapon-related injuries has not been well characterized. To improve characterization of these problems, in 1989, the Massachusetts Department of Public Health (MDPH) began a pilot project to develop the first emergency-department-based statewide Weapon-Related Injury Surveillance System (WRISS) in the United States (3). All 85 hospital emergency departments in Massachusetts (1990 population: 6,016,425) now participate in this system. This report summarizes results from the first 6 months of statewide reporting (November 1993-April 1994), including previously unavailable statewide morbidity data on gunshot and stabbing injuries.
Indirect Validation of Benzene Exposure Assessment by Association with Benzene Poisoning
Authors: M. Dosemeci, S-N. Yin, M. Linet, S. Wacholder, N. Rothman, G-L. Li, W-H. Chow, Y-Z. Wang, Z-L. Jiang, T-R. Dai, W-U. Zhang, X-J. Chao, P-Z. Ye, Q-R. Kou, Y-H. Fan, X-C. Zhang, X-F. Lin, J-F. Meng, J-S. Zho, W. J. Blot, R. B. Hayes
Journal: Environmental Health Perspectives (1996)

We present a validation study of a quantitative retrospective exposure assessment method used in a follow-up study of workers exposed to benzene.Assessment of exposure to benzene was carried out in 672 factories in 12 cities in China.Historical exposure data were collected for 3179 unique job titles.The basic unit for exposure assessment was a factory/work unit/job title combination over seven periods between 1949 and 1987.A total of 18,435 exposure estimates was developed, using all available historical information, including 8477 monitoring data.Overall, 38% of the estimates were based on benzene monitoring data.The highest time-weighted average exposures were observed for the rubber industry (30.7 ppm) and for rubber glue applicators (52.6 ppm).Because of its recognized link with benzene exposure, the association between a clinical diagnosis of benzene poisoning and benzene exposure was evaluated to validate the assessment method that we used in the cohort study.Our confidence in the assessment method is supported by the observation of a strong positive trend between benzene poisoning and various measures, especially recent intensity of exposure to benzene.
Book Review Preventive Medicine . By Mark F. Boyd, M.D., M.S., C.P.H. Member of the regular field staff, International Health Division of the Rockefeller Foundation, formerly Professor of Bacteriology and Preventive Medicine in the Medical Department of the University of Texas. Fourth Edition. Published by W. B. Saunders Company, Philadelphia and London. 1932. Price $4.50.
Journal: New England Journal of Medicine (1933)
Viruses Associated with Upper Respiratory Illnesses in Adults
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Provision of health care for persons with developmental disabilities living in the community. The Morristown model
Authors: P. R. Ziring
Journal: JAMA (1988)

Persons with developmental disabilities living in the community have a greater number and variety of health care needs than the average population of the same age and sex. The erroneous assumption that the generic health care system would be able to provide all necessary services to the large number of individuals recently transferred from state residential facilities to the community has proved to be an unexpected disappointment to human service policymakers. In an effort to remedy this situation, a program of health care services was established by the New Jersey Department of Human Services at a community teaching hospital to supplement the existing generic system of medical care. Within four years, the program had rapidly grown to provide care for 729 patients who had come to rely on the center for primary care, specialty medical and dental services, and medical case management. The demographic characteristics of this program are described as well as data on morbidity, service utilization, and special problems encountered when care was provided to this complex and medically underserved population. (<i>JAMA</i>1988;260:1439-1444)
Arg72Pro P53 gene polymorphism: Clinical relevance and relation with P53 mutations in non-small cell lung cancer (NSCLC) patients
Authors: J. Jassem, A. Szymanowska, E. Jassem, A. Borg, K. Holm, R. Dziadziuszko, W. Rzyman, G. Kobierska-Gulida, J. Limon
Journal: Journal of Clinical Oncology (2004)

7158 Background: The aim of this study was to evaluate the clinical relevance of P53 gene codon 72 polymorphism (Arg72Pro) and its relation with P53 gene mutations in NSCLC patients (pts). Methods: Study group included 157 pts from the North Poland region (35 females and 122 males), aged from 34 to 78 years (mean 60) who underwent curative pulmonary resection between 1996 and 1998. Tumor types included squamous cell (95 pts), adenocarcinoma (41 pts), large cell carcinoma (9 pts), and mixed cell carcinoma (12 pts). Pathological TNM tumor stage distribution was as follows: I (70 pts), II (19 pts), IIIA (59 pts) and IIIB (9 pts). The control group matched for age and cigarette smoking consisted of 519 healthy subjects. P53 gene codon 72 polymorphism (Arg/Arg, Arg/Pro and Pro/Pro) was evaluated by PCR-RFLP and DHPLC methods. Results:The number of Pro allele vs Arg/Arg carriers was insignificantly higher in the NSCLC group than in controls (53.5% vs 46.2%, p=0.11). NSCLC odds ratio for the Pro allele carriers was 1.34 (95% CI: 0.94–1.91). In NSCLC patients polymorphic variants did not correlate with major clinical characteristics and survival. P53 mutations (evaluated by PCR/SSCP technique and sequencing) were found in 47 out of 157 tumor samples (29.9%). There was no correlation between P53 mutations and survival (p=0.87). The presence of Pro allele was associated with increased probability of P53 mutations (p=0.026). Conclusions:Arg72Pro P53 gene polymorphism may carry slightly increased risk of lung cancer and in NSCLC patients is strongly associated with ocurrence of P53 mutations. No significant financial relationships to disclose.
2015 SPCTPD/ACC/AAP/AHA Training Guidelines for Pediatric Cardiology Fellowship Programs (Revision of the 2005 Training Guidelines for Pediatric Cardiology Fellowship Programs)
Authors: Robert D. Ross, Michael Brook, Peter Koenig, Jeffrey A. Feinstein, Peter Lang, Robert L. Spicer, Julie A. Vincent, Alan B. Lewis, Gerard R. Martin, Peter J. Bartz, Peter S. Fischbach, David R. Fulton, G. Paul Matherne, Benjamin Reinking, Robert L. Spicer, Shubhika Srivastava, Beth F. Printz, Tal Geva, Girish S. Shirali, Paul M. Weinberg, Pierre C. Wong, Peter Lang, Laurie B. Armsby, Robert N. Vincent, Susan R. Foerster, Ralf J. Holzer, John W. Moore, Audrey C. Marshall, Larry Latson, Michael Brook, Anne M. Dubin, Edward P. Walsh, Wayne Franklin, Ronald J. Kanter, J. Philip Saul, Maully J. Shah, George F. Van Hare, Julie A. Vincent, Timothy F. Feltes, Stephen J. Roth, Melvin C. Almodovar, Dean B. Andropoulos, Desmond J. Bohn, John M. Costello, Robert J. Gajarski, Antonio R. Mott, Peter Koenig, Karen Stout, Anne Marie Valente, Peter J. Bartz, Stephen Cook, Michelle Gurvitz, Arwa Saidi, Robert D. Ross, Steven A. Webber, Daphne T. Hsu, D. Dunbar Ivy, Thomas J. Kulik, Elfriede Pahl, David N. Rosenthal, W. Robert Morrow, Jeffrey A. Feinstein, William T. Mahle, Anne M. Murphy, Jennifer S. Li, Yuk M. Law, Jane W. Newburger, Stephen R. Daniels, Daniel Bernstein, Bradley S. Marino, Robert D. Ross
Journal: Journal of the American College of Cardiology (2015)
Abstract 13378: Atypical Mechanosensitive MicroRNA-712 Derived From Pre-ribosomal RNA Induces Endothelial Inflammation and Atherosclerosis
Authors: Sandeep Kumar, Dong J Son, Wakako Takabe, Chanwoo Kim, Inhwan Jang, Chih W Ni, Noah Alberts-Grill, Hanjoong Jo
Journal: Circulation (2014)

Atherosclerosis is the underlying cause of cardiovascular events, such as heart attack and stroke, and preferentially occurs in arterial regions exposed to disturbed flow ( d-flow ) by mechanisms involving broad changes in gene expression. While microRNAs (miRNAs) are known to regulate various aspects of cardiovascular biology, their role in atherosclerosis has not been directly demonstrated. We used partial carotid ligation surgery to induce d-flow in the Left carotid artery (LCA) of mouse while the contralateral right carotid artery (RCA) continued to experience stable flow (s-flow). We devised a technique to quickly extract endothelial-enriched RNA from these carotids and performed miRNA array and subsequent validations. Also, using a cone-and-plate shear device, we exposed the immortalized mouse aortic endothelial cells to either laminar or oscillatory shear stress. Use used pre-miR-712 to induce and anti-miR-712 to knockdown the expression of miR-712 in our system. We identified mechanosensitive miRNAs using a mouse partial carotid ligation model and endothelial miRNA array. Of those mechanosensitive miRNAs identified, miR-712 was the most shear-sensitive miRNA upregulated by d-flow both in vivo and in vitro . We found that miR-712 is derived from the internal transcribed spacer 2 (ITS2) region of pre-ribosomal RNA ( RN45S gene) in a XRN1 exonuclease-dependent, but DGCR8-independent manner, suggesting that it is an atypical miRNA derived from an unexpected source. Using gain-of-function (pre-miR-712) and loss-of-function (anti-miR-712) approaches and target-binding assays showed that miR-712 directly downregulated the tissue inhibitor of metalloproteinase 3 (TIMP3) expression. This in turn activated downstream metalloproteinases (MMPs and ADAM family) and stimulated pro-atherogenic responses, endothelial tubule formation and sprouting, in a flow-dependent manner. Treatment with anti-miR-712 prevented atherosclerosis in two different models of murine atherosclerosis using ApoE -/- mice: a chronic conventional western-diet or an acute carotid partial ligation model on a high-fat diet. Targeting mechanosensitive "athero-miRs" with anti-miR-based approaches may provide a new treatment paradigm in atherosclerosis.
WASHINGTON NEWS
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arthroscopic surgery for degenerative knee: systematic review and meta-analysis of benefits and harms
Authors: J. B. Thorlund, C. B. Juhl, E. M. Roos, L. S. Lohmander
Journal: BMJ (2015)

<b>Objective</b> To determine benefits and harms of arthroscopic knee surgery involving partial meniscectomy, debridement, or both for middle aged or older patients with knee pain and degenerative knee disease. <b>Design</b> Systematic review and meta-analysis. <b>Main outcome measures</b> Pain and physical function. <b>Data sources</b> Systematic searches for benefits and harms were carried out in Medline, Embase, CINAHL, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) up to August 2014. Only studies published in 2000 or later were included for harms. <b>Eligibility criteria for selecting studies</b> Randomised controlled trials assessing benefit of arthroscopic surgery involving partial meniscectomy, debridement, or both for patients with or without radiographic signs of osteoarthritis were included. For harms, cohort studies, register based studies, and case series were also allowed. <b>Results</b> The search identified nine trials assessing the benefits of knee arthroscopic surgery in middle aged and older patients with knee pain and degenerative knee disease. The main analysis, combining the primary endpoints of the individual trials from three to 24 months postoperatively, showed a small difference in favour of interventions including arthroscopic surgery compared with control treatments for pain (effect size 0.14, 95% confidence interval 0.03 to 0.26). This difference corresponds to a benefit of 2.4 (95% confidence interval 0.4 to 4.3) mm on a 0-100 mm visual analogue scale. When analysed over time of follow-up, interventions including arthroscopy showed a small benefit of 3-5 mm for pain at three and six months but not later up to 24 months. No significant benefit on physical function was found (effect size 0.09, −0.05 to 0.24). Nine studies reporting on harms were identified. Harms included symptomatic deep venous thrombosis (4.13 (95% confidence interval 1.78 to 9.60) events per 1000 procedures), pulmonary embolism, infection, and death. <b>Conclusions</b> The small inconsequential benefit seen from interventions that include arthroscopy for the degenerative knee is limited in time and absent at one to two years after surgery. Knee arthroscopy is associated with harms. Taken together, these findings do not support the practise of arthroscopic surgery for middle aged or older patients with knee pain with or without signs of osteoarthritis. <b>Systematic review registration</b> PROSPERO CRD42014009145.
Epiphysial fracture of the proximal humerus
Authors: O. E. Aufranc
Journal: JAMA (1970)

Dr. Stuart Cope: The patient is a 13-year-old boy, a junior high school student interested in athletics. He plays on the varsity football, basketball, and golf teams. He was playing sandlot football when he injured his left shoulder. The mechanism of injury was a fall backward on outstretched hand and elbow. He was brought to the emergency room immediately after injury, complaining only of pain in the left shoulder. Examination revealed no neurovascular deficits. X-rays revealed a displaced fracture of the proximal humeral epiphysis through the plate with a fragment off the diaphysis attached to the epiphysis (Fig 1). <h3>Discussion</h3> Dr. Jones: Pertinent to this history and description of lack of neurovascular deficits, additional important information may be obtained by examination of the injured shoulder through palpation and inspection which can be helpful in planning treatment. A portion of this examination should be made with the patient sitting in a
Abstract 13968: Regional Calcified Plaque Score evaluated by Computed Tomographic Angiography for Indicating the Addition of Rotational Atherectomy in Patients With Percutaneous Coronary Intervention
Authors: Teruo Sekimoto, Yasushi Akutsu, Yuji Hamazaki, Hiroaki Tsujita, Shigeto Tsukamoto, Kyouichi Kaneko, Yusuke Kodama, Youichi Kobayashi
Journal: Circulation (2015)

Introduction: Rotational atherectomy (Rota) has been proposed as the best strategy relative to all other percutaneous coronary interventions (PCI) in complex and severely calcified lesions, and the examination of calcified plaque conditions is necessary to determine whether Rota is indicated. Multidetector computed tomography coronary angiography (CTA) can provide non-invasive assessment of calcified plaques with obstructive coronary artery disease. Hypothesis: We hypothesized that regional coronary artery calcium score (CAC) of the target lesion on CTA would aid in deciding whether subsequent intervention strategies should be pursued, including Rota. Methods: Lesion CAC and calcified plaque patterns measured in the target lesion on CTA were evaluated regionally with quantitative coronary analysis (QCA) on angiography for predicting Rota treatment in 116 consecutive patients (168 target lesions) who had undergone their first PCI (mean age ± standard deviations: 68 ± 10 years, females: 19.8%). Results: PCI without Rota was performed successfully in 105 patients (154 lesions), and Rota treatment was added in 11 patients (14 lesions). The patients with Rota had significantly higher SYNTAX score (p=0.007) and CAC than those without Rota (p&lt;0.001). Concerning the target lesions, the primary factors associated with the implementation of Rota included a lesion length of ≥20 mm and a diameter stenosis of ≥74% on QCA (indicates a complex lesion), and a lesion CAC ≥453 and one calcification arc ≥270 on cross-section images on CTA (indicates a severely calcified pattern). After adjustment for potential confounding variables, high lesion CAC (≥453) remains a powerful predictor of Rota treatment with odds ratios of 31.3 [95% confidence interval 2.8-345, p=0.005] (sensitivity: 92.9% and specificity: 88.3%). Conclusions: The lesion CAC as a simple marker of calcified plaque condition in target lesion is useful for indicating the addition of Rota in patients with PCI.
Alcoholism Genes
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2. Classification and Diagnosis of Diabetes:<i>Standards of Medical Care in Diabetes—2019</i>
Journal: Diabetes Care (2018)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.