tbuckley/cabot-search huggingface dataset:
A FACTOR IN THE ANEMIA OF UNCINARIASIS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of a bioartificial liver: Properties and function of a hollow-fiber module inoculated with liver cells
Authors: J Rozga
Journal: Hepatology (1993)

We have developed a bioartificial liver support system utilizing hollow-fiber bioreactor, plasmapheresis and microcarrier cell culture technologies. Liver cells were obtained through portal vein perfusion with ethylenediaminetetraacetate or ethylenediaminetetraacetate/collagenase. A mathematical model of mass transport in a hollow-fiber module, at various plasma flow velocities and system configurations, was developed. The bioartificial liver's ability to carry out specific differentiated metabolic liver functions was tested in vitro and in vivo. A reproducible large-animal model of acute ischemic liver failure was developed. Most major first-generation cyclosporine and 19-norterstosterone metabolites were isolated after substrate addition to the bioartificial liver in vitro. After bioartificial liver treatment for 6 hr (with dog or pig liver cells), dogs with acute liver failure had significantly lower serum ammonia and lactate levels and significantly higher serum glucose levels than did control animals treated with a bioartificial liver system inoculated with microcarriers alone. In addition, bioartificial liver–treated animals had significantly higher mean systolic blood pressures than did controls. Liver cell viability at the end of the 6-hr in vivo experiment was greater than 90%. (HEPATOLOGY 1993;17:258–265.)
Dimethyl sulfoxide. Controversy and current status--1981. Council on scientific affairs
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relief of Pulmonary Hypertensive Pain after Mitral Commissurotomy
Authors: Edward J. Mears, W. Proctor Harvey, Charles A. Hufnagel
Journal: New England Journal of Medicine (1953)

THE similarity of chest pain associated with pulmonary hypertension and that of coronary-artery disease was stressed by Viar and Harrison1 in their excellent monograph. They suggested the term "pulmonary hypertensive pain" and pointed out that it may resemble angina pectoris subjectively in almost every detail. The location is precordial or substernal, but other areas of the thorax may be involved, anteriorly or posteriorly. Radiation when present frequently extends to the left shoulder and arm. The intensity of the pain varies from mild to quite severe. Like angina, the pain with pulmonary hypertension may be precipitated by physical exertion or emotional . . .
David Oliver: Local shouldn’t be a dirty word
Journal: BMJ (2018)

BerkshireAs the NHS approaches its 70th birthday, politicians' desire for central control is as strong as ever.With NHS funding at around 9% of GDP 1 and over a million state employees on the service's payroll, 2 Whitehall's craving for "grip" on the NHS seems undiminished.The risk of services failing to deliver on political imperatives-financial balance and cost improvement programmes, waiting time and access targets, patient safety, dignified essential care-is a high stakes game.Public confidence and satisfaction with local services may suffer, local executives may pay the price, the press could have a field day, and politicians risk damage at the ballot box and the court of public opinion.
Composite operations and reconstruction
Authors: F. X. Paletta
Journal: JAMA (1971)

The present concept regarding defects of the head and neck that are created by cancer therapy is that they require immediate reconstruction. Prior to 1940, the majority of extensive tumors in this region were treated by radiation or cautery. Restoration of the area destroyed by invading cancer cells or therapy was delayed for six months or more. The reason for the delay in repair was to make sure that there was no recurrence of tumor. Many patients walked around with large, unsightly, smelly defects of the face covered by a patchy dressing. Treatment today is directed to a "definitive plan" of management; it may fall into four categories: (1) radiation, (2) combined radiation and surgery, (3) surgery alone, and (4) chemotherapy. The decision of plan to be outlined must come from the "inventory analysis" made about the patient and the tumor. Since there is no laboratory test to evaluate the
Correction: Misaligned Table
Journal: Annals of Internal Medicine (2000)

Corrections20 June 2000Correction: Misaligned TableFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00037 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In Table 3 of a recent review on cyclooxygenase-2 inhibitors (1), several rows are misaligned. On page 140, the row ending “430” should be aligned with the row beginning “Celecoxib group” on page 141; the row ending “784” should be aligned with the row beginning “Not reported”; the row ending “736” should aligned with the row beginning “1 symptomatic ulcer”; and the row ending “1427” should be aligned with the row beginning “150 endoscopic ulcers.”Reference1. Feldman M, McMahon AT. Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal anti-inflammatory drugs, with less gastrointestinal toxicity? Ann Intern Med. 2000;132:134-43. LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDo Cyclooxygenase-2 Inhibitors Provide Benefits Similar to Those of Traditional Nonsteroidal Anti-Inflammatory Drugs, with Less Gastrointestinal Toxicity? Mark Feldman and Alexander T. McMahon Metrics 20 June 2000Volume 132, Issue 12Page: 1011KeywordsUlcers Issue Published: 20 June 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract MP30: Metabolomic Profiles Associated with Aging in Women
Authors: Kathryn M Rexrode, Raji Balasubramanian, Nina Paynter, JoAnn Manson, Jiu-Chiuan Chen, Mara Vitolins, Christine Albert, Clary Clish
Journal: Circulation (2016)

Background: Aging is a complex process that results from metabolic activities such as those that generate reactive oxygen species. Metabolomic profiling, an emerging technology, may shed light on metabolites associated with aging and identify key changes associated with premature aging. Methods: A total of 370 metabolites were profiled using liquid chromatography tandem mass spectroscopy (LC-MS) in plasma from 1153 healthy, control subjects in the Women’s Health Initiative. Metabolite levels were log-transformed and standardized, and each considered individually in statistical models. Linear regression models were created with the metabolite as the outcome and age as the primary exposure: &lt;60 (referent), 60-&lt;65, 65-&lt;70, 70-&lt;75, and 75 years and older. Models were adjusted for matching factors in the primary study (race, time period, hysterectomy status, and then additionally for body mass index, medications (antihypertensives, anti-diabetic drugs, aspirin and statins), and creatinine. The likelihood ratio test was used to compare models with age to model without age, with adjustment for false discovery rate (FDR). Significant results were defined as FDR adjusted p&lt;0.05. Results: The median age of the women was 68 years (interquartile range 62-72). After multivariate adjustment, thirty-nine metabolites were significantly associated with age &gt;75, including 12 acylcarnitines, 11 free fatty acids, 9 fatty acid derivatives, 2 amino acids, and 5 additional metabolites. Of these, octadecenoyl-L-carnitine (C18:1) had the strongest age association, with levels 0.70 SD (95% CI: 0.48-0.92) higher on average among women &gt; 75 years compared to women &lt;60 years of age (referent). C22:0 sphingomyelin (SM), threonine and C24:0 SM were negatively associate with age; levels of these metabolites were on average 0.41 to 0.44 SD lower among the women 75 years and older when compared to the youngest women (linear trend FDR-p value &lt;0.05 for all of these metabolites). Conclusions: Multiple metabolites involved in mitochondrial fatty acid oxidation, as well as several associated with insulin resistance, have a strong relationship with age, even after adjusting for multiple age-associated factors.
Beauty today and youth tomorrow?
Authors: R. S. Stern
Journal: JAMA (1988)

As demonstrated by the simultaneous proliferation of tanning salons and a tremendous growth in interest in new agents that may reverse photoaging or at least wrinkles that accompany tanning, many people want both.<sup>1</sup>In this month's<i>Archives of Dermatology</i>, Bech-Thomsen and colleagues<sup>2</sup>present provocative data suggesting that in hairless mice, preirradiation with long-wave (A range) ultraviolet radiation (UV-A), similar to the wavelengths emitted by most tanning salon units, provides significant protection against the development of skin tumors in mice subsequently exposed to broad-band ultraviolet radiation (ie, the sun). These well-designed experiments suggest that, at least in the hairless mouse, a brief visit to a tanning parlor before exposure to the sun (ie, both sunburn-spectrum [B range] ultraviolet radiation [UV-B] and UV-A) might help reduce the risk of sun-induced nonmelanoma skin cancer. Somewhat surprisingly, the authors do not relate this apparent protective effect of preirradiation to increases in skin
Opposite Clinical Phenotypes of “Glucokinase Disease”: Description of a Novel Activating Mutation and Contiguous Inactivating Mutations in Human Glucokinase Gene
Authors: Fabrizio Barbetti, Nadia Cobo-Vuilleumier, Carlo Dionisi-Vici, Sonia Toni, Paolo Ciampalini, Ornella Massa, Pablo Rodriguez-Bada, Carlo Colombo, Lorenzo Lenzi, María A. Garcia-Gimeno, Francisco J. Bermudez, Fernando Rodriguez de Fonseca, Patrizia Banin, Juan C. Aledo, Elena Baixeras, Pascual Sanz, Antonio L. Cuesta-Muñoz
Journal: Endocrine Reviews (2009)

ABSTRACT Glucokinase (GK) is essential for glucose-stimulated insulin release from pancreatic β-cell, serving as glucose sensor in humans. Inactivating or activating mutations of glucokinase lead to different forms of “Glucokinase Disease”, i.e. Monogenic Diabetes of Youth (GCK-MDY), Permanent Neonatal Diabetes (inactivating mutations) and Congenital Hyperinsulinism, respectively. Here we present a novel GCK activating mutation (p.E442K) found in an infant with neonatal hypoglycemia (1.5 mmol/l) and in two other family members suffering from recurrent hypoglycemic episodes in their childhood and adult life. In contrast to the severe clinical presentation in the index case, functional studies showed only a slight activation of the protein (relative activity index of 3.3). We also report on functional studies of two inactivating mutations of the GCK (p.E440G and p.S441W), contiguous to the activating one, that lead to GCK-MDY. Interestingly, adult family members carrying the GCK pE440G mutation show an unusually “heterogeneous and progressive” diabetic phenotype, a feature not typical of MDY. In summary, we identified a novel activating GCK mutation that although being associated with severe neonatal hypoglycemia is characterized by the mildest activation of the glucokinase enzyme of all previously reported.
Abscess of the Posterior Nasal Septum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
November 1976, Vol. 57, No.5
Journal: JNCI Journal of the National Cancer Institute (1977)

November 1976, Vol. 57, No.5 Get access JNCI: Journal of the National Cancer Institute, Volume 58, Issue 3, March 1977, Page 819, https://doi.org/10.1093/jnci/58.3.819-b Published: 01 March 1977
Outbreaks of Hepatitis B Virus Infection Among Hemodialysis Patients—California, Nebraska, and Texas, 1994
Journal: JAMA (1996)

From April through August 1994, outbreaks of hepatitis B virus (HBV) infection occurred in five chronic hemodialysis centers in California, Nebraska, and Texas. This report summarizes investigations by state and local public health officials and CDC, which suggest that transmission of HBV from hemodialysis patients with chronic HBV infection to susceptible patients resulted from failure to identify and isolate HBV-infected patients during hemodialysis; sharing of staff, equipment, and supplies among patients; and failure to vaccinate susceptible patients against hepatitis B.
Pseudofolliculitis barbae. No 'pseudoproblem'
Authors: M. S. Conte
Journal: JAMA (1979)

Pseudofolliculitis barbae possibly affects 45% of all black servicemen and is a source of much misunderstanding and social unrest in the military. A recent study of 96 cases of pseudofolliculitis barbae has elucidated a successful shaving technique. It employs a 30-day period of beard regrowth to eliminate ingrown hairs, twice-daily use of a new polyester skin-cleansing pad, and use of solely electric hair clippers for facial hair removal. Ninety-six percent of those using this technique could thereafter conform to the Air Force grooming code. (<i>JAMA</i>241:53-54, 1979)
Associations of Blood Lead, Dimercaptosuccinic Acid-Chelatable Lead, and Tibia Lead with Polymorphisms in the Vitamin D Receptor and d-Aminolevulinic Acid Dehydratase Genes
Authors: Brian S. Schwartz, Byung-Kook Lee, Gap-Soo Lee, Walter F. Stewart, David Simon, Karl Kelsey, Andrew C. Todd
Journal: Environmental Health Perspectives (2000)

A cross-sectional study was performed to evaluate the influence of polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes on blood lead, tibia lead, and dimercaptosuccinic acid (DMSA)-chelatable lead levels in 798 lead workers and 135 controls without occupational lead exposure in the Republic of Korea.Tibia lead was assessed with a 30-min measurement by 109 Cd-induced K-shell X-ray fluorescence, and DMSAchelatable lead was estimated as 4-hr urinary lead excretion after oral administration of 10 mg/kg DMSA.The primary goals of the analysis were to examine blood lead, tibia lead, and DMSAchelatable lead levels by ALAD and VDR genotypes, controlling for covariates; and to evaluate whether ALAD and VDR genotype modified relations among the different lead biomarkers.There was a wide range of blood lead (4-86 µg/dL), tibia lead ( -7-338 µg Pb/g bone mineral), and DMSA-chelatable lead (4.8-2,103 µg) levels among lead workers.Among lead workers, 9.9% (n = 79) were heterozygous for the ALAD 2 allele and there were no homozygotes.For VDR, 10.7% (n = 85) had the Bb genotype, and 0.5% (n = 4) had the BB genotype.Although the ALAD and VDR genes are located on different chromosomes, lead workers homozygous for the ALAD 1 allele were much less likely to have the VDR bb genotype (crude odds ratio = 0.29, 95% exact confidence interval = 0.06-0.91).In adjusted analyses, subjects with the ALAD 2 allele had higher blood lead levels (on average, 2.9 µg/dL, p = 0.07) but no difference in tibia lead levels compared with subjects without the allele.In adjusted analyses, lead workers with the VDR B allele had significantly (p < 0.05) higher blood lead levels (on average, 4.2 µg/dL), chelatable lead levels (on average, 37.3 µg), and tibia lead levels (on average, 6.4 µg/g) than did workers with the VDR bb genotype.The current data confirm past observations that the ALAD gene modifies the toxicokinetics of lead and also provides new evidence that the VDR gene does so as well.
Tamoxifen flare
Authors: J. D. Veldhuis
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The recent article "Tamoxifen Flare in Advanced Breast Cancer" by Plotkin et al (240:2644, 1978) emphasizes an often-ignored phenomenon. We have analyzed our experience with this agent in treating 68 postmenopausal patients with advanced breast cancer. The flare phenomenon was specifically sought in a prospective fashion. Six patients experienced a transient flare of bone or soft-tissue pain. One of these flares was accompanied by mild and transient hypercalcemia. Of these six patients, two attained objective response, and one showed a subjective improvement accompanied by a lessthan-50% reduction in measurable disease. Two patients had progressive disease while receiving tamoxifen citrate. Early in the study, tamoxifen therapy was discontinued in one patient because of flare, before there was any. possibility of evaluating her response. She subsequently failed to respond to therapy with doxorubicin hydrochloride (Adriamycin) or megestral acetate (Megace) before dying of progressive disease three months after the tamoxifen
A pseudoepidemic due to atypical mycobacteria in a hospital water supply
Authors: T. M. Stine
Journal: JAMA (1987)

We describe a pseudoepidemic due to atypical mycobacteria contaminating the water used by a pathology laboratory and bronchoscopy suite on two floors of the same hospital building. Inspection of laboratory procedures revealed that contamination occurred during specimen processing in pathology and while obtaining the bronchoscopic specimens.<i>Mycobacterium gordonae, Mycobacterium avium</i>complex, and<i>Mycobacterium scrofulaceum</i>were identified. During an eight-month period, a total of 22 (31%) of 70 patients with positive acid-fast smears had either an illness inconsistent with tuberculosis or a known alternate diagnosis. Control was easily obtained by insertion of a 0.2-μm polymer filter into the outflow tubing of our pathology tap water-deionizing unit and the tap water source in the bronchoscopy suite. The pseudoepidemic led to additional diagnostic-therapeutic intervention, but no patient experienced delay in appropriate diagnosis. Pseudoepidemics due to atypical mycobacteria will likely be of increased importance in institutions providing care to patients with acquired immunodeficiency syndrome. (<i>JAMA</i>1987;258:809-811)
Mandatory vs Permissive Licensure for Nurses
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal