tbuckley/cabot-search huggingface dataset:
Review, Discussion, and Summary: Toxicology
Authors: Judith A. Graham
Journal: Environmental Health Perspectives (1989)

The research presented in the toxicology session of the Symposium on the Health Effects of Acid Aerosols significantly advances our understanding of the health effects of acid aerosols and clearly illustrates the importance of animal inhalation toxicology to risk assessment. The description of the effects of acid on airway mucus buffering capacity and viscosity helps explain some of the mechanisms responsible for the effects of sulfuric acid on mucociliary clearance and pulmonary function observed in man and animals. Several of the papers illustrate that other pollutants interact with sulfuric acid (H2SO4), causing concern about exposure risks and helping in elucidating the effects observed in epidemiology studies that have not yet been duplicated in a laboratory. For example, H2SO4 absorbed in zinc oxide (ZnO) particles appears to be about a log more potent than H2SO4 alone in causing pulmonary function decrements. Low levels of H2SO4 and O3 were found to be synergistic in increasing collagen synthesis, implying a risk in development of lung fibrosis. More complex mixtures containing H2SO4 cause a variety of interactions, depending upon the end points examined and the chemistry of the mixture. Other reports indicate that dose rate and length of exposure issues are critical to toxicological outcomes. Animal data on mucociliary clearance, which parallels that of human data, was extended to show that concentration of exposure was more important than time of exposure in eliciting a response, although time played a significant role. A recent chronic study showed that H2SO4 caused effects that also can occur in the development of chronic bronchitis.(ABSTRACT TRUNCATED AT 250 WORDS)
Incorrect Value in Figure
Authors: Sean Cahill, Kenneth Mayer, Stephen Boswell, Ezekiel Emanuel
Journal: JAMA (2017)

Daniel E. Jonas, MD, MPH; Halle R. Amick, MSPH; Cynthia Feltner, MD, MPH; Rachel Palmieri Weber, PhD; Marina Arvanitis, MD, MPH; Alexander Stine, BA; Linda Lux, MPA; Russell P. Harris, MD, MPH
Brief Overview of Selected Aspects of Testicular Hormone Action
Authors: Leslie P. Bullock
Journal: Environmental Health Perspectives (1981)

This paper is designed to give an overview of the mechanism of androgen action and some of the factors that can affect it. The discussion of androgen action includes androgen transport in the blood, metabolism, receptor binding, nuclear activation and selected aspects of biological response. The importance of recognizing interspecies and interstrain differences in specific aspects of androgen action is mentioned. Some examples of the effects of environmental agents on androgen metabolism, receptor binding and biological response are included.
GYNERGEN SANDOZ
Authors: Walter M. Fletcher
Journal: JAMA (1930)

<h3>To the Editor:</h3> —The attention of the Medical Research Council (Great Britain) has been drawn to a misleading advertisement, involving misuse of their name, which has been given currency on the American continent in respect of a preparation of ergotamine tartrate known as Gynergen "Sandoz." This advertisement states that "The Pharmaceutical Society of Great Britain, after consultation with the Medical Research Council, adopted Gynergen as the standard for ergot, thus making it the acknowledged leader in this field." This statement is not true. The Medical Research Council desire to make it plain that they never at any time concurred in, or were consulted about, the adoption of this preparation as a standard. The suggestion made with reference to the council is therefore entirely without foundation, and any statement implying their approval is a gross misrepresentation. Further, the current official publications of the Pharmaceutical Society of Great Britain state expressly that
Forensics, History
Authors: Werner Jacobs, Marc De Leeuw
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL LICENSURE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Petit and grand mal convulsions during lidocaine hydrochloride treatment of ventricular tachycardia
Authors: R. S. Crampton
Journal: JAMA (1968)

Euphoria, confusion, petit and grand mal convulsions, and respiratory arrest associated with infusion of lidocaine hydrochloride occurred in a patient with myocardial infarction. The neurological complications caused catastrophic deterioration of the patient's condition. The increasing use of lidocaine intravenously to treat ventricular arrhythmias makes it advisable that physicians become acquainted with the early neurological symptoms and signs of lidocaine toxicity.
THE "HYOSCIN-MORPHIN-CACTIN" ANESTHESIA.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
L'immunité par mécanisme physico-chimique
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Devices for Diagnosis
Journal: Annals of Internal Medicine (1961)

Editorials1 October 1961Devices for DiagnosisE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-702 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiagnosis* is the indispensable bridge between illness and cure. To the patient, all medical research and knowledge are worthless if they cannot be used to return him to health. But there may be no cure if his illness cannot be identified.Diagnosis as method suffers now from two major defects. The first is our ignorance of how many lesions, either tissue or chemical, produce their symptoms and signs. Were these gaps closed we might be able to reason back from effect to cause, from the complaints of the patient to the nature of the disorder in all cases, as simply...References1. YATEROLIVER WMWF: Symptom Diagnosis, 5th Ed., Appleton-Century-Crofts, Inc., New York, 1961. Google Scholar2. NASH FA a. : Diagnostic reasoning and the Logoscope. Lancet 2: 1442, 1960. b. NASH, F. A.: The mechanical conservation of experience, especially in medicine. IRE Trans. Med. Electronics 7: 240, 1960. CrossrefMedlineGoogle Scholar3. PETERSDORFBEESON RGP: Fever of unexplained origin: report of 100 cases. Medicine 40: 1, 1961. CrossrefMedlineGoogle Scholar4. CAMPBELLCARON JDHS: Data processing by optical coincidence. Science 133: 1333, 1961. CrossrefMedlineGoogle Scholar5. LIPKINHARDY MJD: Mechanical correlation of data in differential diagnosis of hematological diseases. J. A. M. A. 166: 113, 1958. CrossrefMedlineGoogle Scholar6. LIPKINENGLEDAVISZWORYKINEBALDSINDROWBUKLEY MRLBJVKRMC: Digital computers as aid to differential diagnosis: use in hematologic diseases. Arch. Intern. Med. 108: 56, 1961. CrossrefMedlineGoogle Scholar7. WARNERTORONTOVEASEYSTEPHENSON HRAFLGR: A mathematical approach to medical diagnosis. Application to congenital heart disease. J. A. M. A. 177: 177, 1961. CrossrefMedlineGoogle Scholar8. LEDLEYLUSTED RSLB: Reasoning foundations of medical diagnosis. Science 130: 9, 1959. CrossrefMedlineGoogle Scholar9. LEDLEYLUSTED RSLB: The use of electronic computers in medical data processing: aids in diagnosis, current information retrieval, and medical record keeping. IRE Trans. Med. Electronics 7: 31, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *"Diagnosis" in this editorial has two meanings: the logical process, conscious or unconscious, by which the patient's disorder is identified as a previously-described disease, from the findings in his case; and the label, itself, for the patient's disease. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1961Volume 55, Issue 4Page: 702-707KeywordsLesionsSigns and symptoms Issue Published: 1 October 1961 PDF DownloadLoading ...
Breast Cancer
Authors: Chandrakant C. Kapdi
Journal: JAMA (1976)

This study was undertaken to determine the relationship between thyroid supplements and breast cancer. The incidence of breast cancer among the patients who received thyroid supplements was 12.13%, while in the control group it was 6.2%. The incidence rate of breast cancer was 10%, 9.42%, and 19.48% among patients who received thyroid supplements for one to five, 5 to 15, and for more than 15 years, respectively. The incidence of breast cancer among nulliparous women who received thyroid supplements was 33%, while in the nulliparous women without thyroid supplements the incidence was only 9.25%. Even in a specific age group, the incidence rate of breast cancer was higher among patients receiving thyroid supplements, when compared to the control patients in the same age group. (<i>JAMA</i>236:1124-1127, 1976)
A clinical trial of change in maternal smoking and its effect on birth weight
Authors: M. Sexton
Journal: JAMA (1984)

These clinical trial results are the first, to our knowledge, from a prospective, randomized, and controlled experiment demonstrating that a reduction of smoking during pregnancy improves the birth weight of the infant. Nine hundred thirty-five pregnant smokers were randomly assigned to treatment and control groups; the former received smoking intervention. At the eighth month of pregnancy, differences between the two groups in salivary thiocyanate level and reported smoking were statistically significant. For single, live births, the treatment group infants had a mean birth weight that was 92 g heavier and were 0.6 cm greater in length than the control group infants. The decrement in weight related to smoking cannot be fully explained by gestational age. The findings suggest that some fetal growth retardation can be overcome by the provision of antismoking assistance to pregnant women. (<i>JAMA</i>1984;251:911-915)
Genetic services in the United States
Authors: S. J. Sepe
Journal: JAMA (1982)

In fiscal years 1979 and 1980, the Genetic Diseases Service Branch of the Health Services Administration funded 34 state genetic service programs in the United States through monies from the National Genetic Diseases Act (PL 94-278) of 1976. During the two-year period, 131,818 at-risk individuals were provided with genetic counseling. Analyses of amniotic fluid were performed on 42,003 specimens, with 436 abnormal fetuses (1%) detected. Utilization ratios of amniocentesis for advanced maternal age ranged from a low of 5% to a high of 49%. Screening programs for inborn errors of metabolism reported testing 3,158,521 specimens. The numbers of affected children detected nationally were 195 with phenylketonuria (1:16,000), 536 with hypothyroidism (1:5,900), 25 with galactosemia (1:39,685), eight with maple syrup urine disease (1:86,984), and eight with homocystinuria (1:139,008). (<i>JAMA</i>1982;248:1733-1735)
Increased expression of cardiotrophin-1 and gp 130 during transition from hypertrophy to ventricular dilatation in hypertensive rats Yoshihito Takimoto, Takeshi Aoyama, Yoshitaka Iwanaga, Toshiaki Izumi, Yasuki Kihara, Shigetake Sasayama. Kyoto University, Kyoto, Japan
Journal: Journal of the American College of Cardiology (2001)
From Theater to Laboratory
Authors: J. Bender
Journal: JAMA (2002)

played by Cary Grant, is followed everywhere by a large, silent man.The man is with him as he addresses an anatomy class, as he conducts the student orchestra, as he stands over a patient in the operating room.The man speaks only at rare moments, each crucial, coming to Noah's aid as the voice of wisdom, of conscience, or of the past.When Noah is finally challenged by a university tribunal to defend his relationship with the odd man he calls "my friend," the story comes out: the man is a convicted murderer, executed by hanging and sent 20 years earlier to Noah, a medical student who needed "a cadaver of my own."The "cadaver" awakened as soon as Noah stuck a gloved finger in his mouth, and has never since left his side.Early experiences in the anatomy laboratory underpin later practice in ways that are not easy to articulate.The knowledge gained there guides diagnosis, allows us to link phenomena that seem on the body's surface to be unrelated, and gives us fluency in a discourse that lets us to describe what is happening to our patients.Visualizing the structures hidden beneath the skin allows us to identify conditions otherwise beyond our grasp.Although the overwhelming bulk of the knowledge we use to care for patients is learned outside the lab, and the centrality of the experience wanes even by the end of first year, what we learn in anatomy lab is somehow, quietly, always there.In this issue of MSJAMA, literature professor John Bender recounts his season as an outsider in the lab and describes how the process serves as a ritual entry into the medical profession.Beyond the technical knowledge it affords, anatomy lab links us to the past and begins our socialization to future practice.We dissect knowing that we are making the same cuts and seeking the same structures as physicians centuries earlier.But today, we pride ourselves on taking more from the experience, on engaging with the gift that is the donation.Samantha Stewart and Rita Charon describe anatomy study as an initial confrontation with life and death that will follow us throughout our careers, and discuss a way these early lessons might be retrieved.S. Ryan Gregory and Thomas Cole describe the history of dissection across centuries, while Aaron Tward and Hugh Patterson account for the shift from grave robbing to cadaver donation in the United States.Finally, to launch our new creative writing section murmur, Matthew Ehrlich evaluates his cadaver's chief complaint.The first body in our care has neither the needs nor the agency of a patient, and yet for many of us, it is the body we will envision as we examine the intact surface of each patient who comes to us.Whether it is our initiation into "the professional tribe of physicians" (Bender), "the scientific method" (Gregory and Cole), or "the use of affective responses" (Stewart and Charon), anatomy lab is as much a part of how we see as what we know."The trouble with you, Elwell," Noah's ally says to his accuser at the end, "is you've never had a cadaver of your own."
A randomized, double-blind, placebo-controlled phase III study of ramucirumab versus placebo as second-line treatment in patients with hepatocellular carcinoma and elevated baseline alpha-fetoprotein following first-line sorafenib (REACH-2)
Authors: A.X. Zhu, P.R. Galle, M. Kudo, R. Finn, L. Yang, P. Abada, J.M. Llovet
Journal: Annals of Oncology (2016)
Conjugate Hib vaccines given in infancy without booster doses may produce long term protection
Journal: BMJ (1998)

Cognitive behaviour therapy is promising in childhood depressive disorderOver the past 15 years there has been increasing recognition that children suffer depressive conditions.A systematic review concluded that tricyclics were of unproved benefit.On p 1559 Harrington et al present a systematic review of six trials of a common psychological treatment-cognitive behaviour therapy.The results suggest that it may be useful in mild or moderately severe cases of juvenile depression.Studies that compare cognitive behaviour therapy with antidepressant medication are now required.
LETTER FROM BALTIMORE.
Authors: None E. F. C.
Journal: JAMA (1890)

(FROM OUR OWN CORRESPONDENT.) Prof. Wm. H. Welch on Arterio-Sclerosis—The Attendance at the Medical and Dental Colleges— The opening Lectures—The Johns Hopkins Hospital—The Reconstructed College of Physicians and Surgeons—What the Faculty of the University of Maryland are doing—A new Homœpathic Medical College—The Baltimore Medical and Surgical Record—Miscellaneous Gleanings. The colleges and societies have fully resumed work for the season, and with most flattering prospects. Our chief medical society, the " Clinical," elected for its presiding officer for the current year Dr. Hiram Woods, Professor of Diseases of the Eye and Ear at the Woman's Medical College and Assistant Surgeon of the Presbyterian Eye and Ear Hospital, who has been an active worker among the younger set. The feature of the first business meeting of the same society, held last Friday week, was a paper, or more properly a lecture, by Prof. William H. Welch, of the Johns Hopkins Hospital, on " Arterio-Sclerosis."
Corrigendum to “Local Administration of an Adeno-Associated Viral Vector Expressing IL-10 Reduces Monocyte Infiltration and Subsequent Photoreceptor Damage During Experimental Autoimmune Uveitis”
Authors: Cathryn A. Broderick, Alexander J. Smith, Kam S. Balaggan, Anastasios Georgiadis, Prateek K. Buch, Peter C. Trittibach, Susie E. Barker, Gian-Marco Sarra, Adrian J. Thrasher, Andrew D. Dick, Robin R. Ali
Journal: Molecular Therapy (2005)

The authors regret that the name of Anastasios Georgiadis was incorrectly listed as Anastasios Georgarias in the author line. The correct author line appears above. Local Administration of an Adeno-associated Viral Vector Expressing IL-10 Reduces Monocyte Infiltration and Subsequent Photoreceptor Damage during Experimental Autoimmune UveitisBroderick et al.Molecular TherapyAugust, 2005In BriefAutoimmune posterior uveitis is a chronic, potentially blinding inflammatory disease of the eye. It is commonly treated with immunosuppressive drugs that have adverse long-term effects. Advances in gene transfer techniques have enabled long-term, stable transduction of retinal cells following subretinal injection with adeno-associated viral (AAV) vectors. Here we report for the first time that subretinal injection of rAAV-2 encoding murine IL-10 into the retina of C57BL/6 mice significantly decreases the median experimental autoimmune uveitis (EAU) disease severity. Full-Text PDF Open Archive
Smoking Habits and Age in Relation to Pulmonary Changes: Rupture of Alveolar Septums, Fibrosis, and Thickening of Walls of Small Arteries and Arterioles
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal