tbuckley/cabot-search huggingface dataset:
Policy options for public long-term care insurance
Authors: E. C. Norton
Journal: JAMA (1994)

CONTROVERSY surrounds the place of long-term care insurance as part of national health system reform and the nature of such insurance if it is to be part of the reform. Some groups, most notably those representing older adults, believe that the current financing system, which relies heavily on the Medicaid program, must be altered. Others would not modify present arrangements, at least in the short run. Under current law, individuals are eligible for nursing home benefits through Medicaid if they have few assets other than housing equity. The following proposals would markedly change these arrangements: The Pepper Commission1 recommends a universal insurance system for those sufficiently disabled, but limits benefits to an initial period of 3 months. After 3 months, nursing home residents would pay for everything, unless they are poor enough to qualify for coverage similar to the current Medicaid program. Analysts at the Brookings Institution<sup>2</sup>advocate expanding the
Recent trends and intention-to-treat survival of liver transplantation for non-alcoholic steatohepatitis: an Italian liver transplant registry study. On behalf of AISF, FIRE, SITO and CNT
Authors: Alessandro Vitale, Silvia Trapani, Patrizia Burra, Alessandra Bertacco, Renato Romagnoli, Silvia Martini, Paolo De Simone, Paola Carrai, Matteo Cescon, Maria Cristina Morelli, Luciano De Carlis, Luca Saverio Belli, Salvatore Gruttadauria, Riccardo Volpes, Michele Colledan, Stefano Fagiuoli, Giorgio Rossi, Maria Francesca Donato, Fabrizio Di Benedetto, Nicola De Maria, Umberto Tedeschi, Antonio Colecchia, Andrea Ricci, Massimo Cardillo, Umberto Cillo
Journal: Journal of Hepatology (2020)
Correction: Novel Oncolytic Adenovirus Selectively Targets Tumor-Associated Polo-Like Kinase 1 and Tumor Cell Viability
Authors: Jianfeng Zhou, Qinglei Gao, Gang Chen, Xiaoyuan Huang, Yunping Lu, Kanyan Li, Daxing Xie, Liang Zhuang, Jingniu Deng, Ding Ma
Journal: Clinical Cancer Research (2019)
Prediabetes Is Being Overlooked
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistent Amnesia
Authors: F. McLaughlin
Journal: BMJ (1949)

<h3>BACKGROUND:</h3> Unplanned extubation (UE) is a common adverse event and is an important measure of quality and patient safety in the neonatal ICU. It is well recognized that UEs occur more frequently in neonates than in any other group of ventilated patients. The objective of this study was to evaluate the effectiveness of the quality improvement interventions in reducing the rates of UE in a tertiary neonatal ICU. <h3>METHODS:</h3> A retrospective audit performed on ventilated infants showed a rate of 7.2 unplanned extubations per 100 ventilation days in a 12-month period (April 2016 to March 2017). We evaluated the common factors associated with UEs, with the primary reasons being loose fixation and providing care without assistance. We introduced sequential interventions focusing on better practices. Standardizing endotracheal tube fixation, continuous scrutiny of fixation through checks, 2-person technique for providing care, and adverse event reporting were a few of the important interventions. Rates of UE for each month were collected and analyzed. <h3>RESULTS:</h3> With interventions, UE rates reduced by 80% (from 7.2 per 100 ventilated days in the pre-implementation period to 1.4 per 100 ventilated days in the post-implementation period) in 12–18 months. <h3>CONCLUSIONS:</h3> Significant reductions in UE rates were achieved by implementing quality improvement interventions. It is important to analyze critical event rates continuously and for longer periods of time to determine the true change.
Economic Problems of Medicine
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Xeromammography
Authors: William D. Hayford
Journal: JAMA (1976)

<h3>To the Editor.—</h3> As a primary care physician, I was distressed by the Kalisher-Schaffer article (234:60, 1975). This review of a diagnostic procedure may have disastrous results if taken at face value. The article never gives an age breakdown of the women studied and makes no mention of possible long-range side effects of the excessive radiation required by this roentgenographic technique. The Food and Drug Administration<i>Drug Bulletin</i>, dated April-June 1975, quotes the American College of Radiology as being opposed to routine screening of asymptomatic women under the age of 35 years. The panel that made the recommendation further stated that the efficacy of screening asymptomatic women in the age group 35 to 50 is still in question. Kalisher and Schaffer admitted that 15% of the women were studied though asymptomatic, and 15% just because they were considered high-risk. While 27 centers participating in the current demonstration study throughout the
Diagnosis of meralgia paresthetica
Authors: A. D. Ecker
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Meralgia paresthetica (MP) is a disorder of the lateral femoral cutaneous nerve, the sensory nerve of the anterolateral aspect of the thigh. The symptoms are intermittent numbness, tingling, pain, and/or a burning sensation, often worse when standing or walking. Diagnosis utilizing contact chromothermography was recently reported in a case of MP.<sup>1</sup>My experience with this technique in 14 such cases yielded the following results in the affected region: six were isothermic (temperature equal to that of surrounding skin and of the opposite thigh), five were hypothermic (cool), and three were hyperthermic (warm). There was no correlation with either duration of symptoms or intensity of sensory impairment. Forty-six years ago, Dr Woltman and I<sup>2</sup>reported that "appreciation of touch, pain and temperature was diminished in 68 per cent of 150 cases." Since then, in about 200 cases of MP, I have usually found the following sensory
Biological Markers in Reproductive Epidemiology: Prospects and Precautions
Authors: Zena Stein, Maureen Hatch
Journal: Environmental Health Perspectives (1987)

We begin by defining "biological markers" for the purposes of the present review, distinguishing markers from other types of information, such as subject reports or conventional clinical data. We find the distinctions to be hazy. Next, from the standpoint of epidemiologists, we set out circumstances in which exposure markers might be needed, suggesting requirements for useful markers. We give two instances (lead, PCB), drawn from studies of female reproduction, where the use of exposure markers is compared to environmental or anamnestic data. Effect markers are considered in turn. It is argued that their usefulness (if they are to be more informative than exposure markers) depends on their sensitivity and specificity in relation to the disease outcome. Also, their timeliness, and the use that can be made of the gain in time, for individuals and populations is discussed. In this context, we consider markers of events before and around fertilization; more specifically, we consider those events that precede the clinical marker of the first missed period. In returning to the potential uses of biological markers in discovering or interpreting female reproductive disorders that might be owed to environmental causes, we compare markers of the pre- and peri-implantation phases with markers of the postimplantation phase, drawing on experience with studies of chromosome anomaly in spontaneous abortion. Finally, we suggest other sensitive reproductive processes for which biological markers might usefully be developed.
Elevated Lipoprotein(a) and Premature Coronary Heart Disease
Authors: Vincent M. G. Maher
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The article by Dr Bostom and colleagues<sup>1</sup>reaffirms the importance of an elevated lipoprotein(a) [Lp(a)] level as a cardiac risk factor. We have postulated previously, based on our analysis of published works,<sup>2</sup>that a pathological interaction exists between increased Lp(a) levels and elevated low-density lipoprotein (LDL) cholesterol levels, which is confirmed by our own experience.<sup>3</sup>Furthermore, by lowering LDL cholesterol levels alone, the adverse effects of the interaction of these 2 particles is greatly diminished.<sup>3</sup> Bostom and colleagues did not observe such an interaction. The most likely explanation is that LDL cholesterol levels in their study were low (mean, 3.5 mmol/L [135 mg/dL]) relative to the mean LDL cholesterol levels in most studies previously published.<sup>2</sup>We observed that, in the presence of such low LDL cholesterol levels, increased Lp(a) levels had only a small or negligible impact on disease outcome.<sup>2</sup>In
New England Journal of Medicine, Boston
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evolution of osteoporosis.
Authors: D W Purdie
Journal: Annals of the Rheumatic Diseases (1996)

<h3>Abstract</h3> Vaccine development against the SARS-CoV-2 virus focuses on the principal target of the neutralizing immune response, the spike (S) glycoprotein. Adenovirus-vectored vaccines offer an effective platform for the delivery of viral antigen, but it is important for the generation of neutralizing antibodies that they produce appropriately processed and assembled viral antigen that mimics that observed on the SARS-CoV-2 virus. Here, we describe the structure, conformation and glycosylation of the S protein derived from the adenovirus-vectored ChAdOx1 nCoV-19/AZD1222 vaccine. We demonstrate native-like post-translational processing and assembly, and reveal the expression of S proteins on the surface of cells adopting the trimeric prefusion conformation. The data presented here confirms the use of ChAdOx1 adenovirus vectors as a leading platform technology for SARS-CoV-2 vaccines.
Abstract 3991: ONCOTARGET (ONCOALVO): A custom NGS panel for therapeutic decision in solid tumors refractory to conventional therapy
Authors: Andre M. Murad, Jose Claudio Casali-da-Rocha, Juliana G. Carneiro, Ana L. Godard
Journal: Cancer Research (2019)

Abstract Next-generation sequencing (NGS) of tumor biopsies of both solid tumors, as well as hematological malignancies, using commercially available platforms has broadly entered routine clinical practice in medical oncology. This molecular diagnostic approach is now used mainly to test for predictive biomarkers for patients with no available further standard therapies, as diagnostics rely on genomic testing of molecular alterations to enable effective cancer treatment. However, the high cost of large multigenic panels and especially the sequencing of the entire tumor exome is a concern, especially in a developing country such as Brazil. Here we report the clinical application of a panel of 57 genes that we call ONCOTARGET (ONCOALVO) which is based on the Thermo Fisher Oncomine Focus Assay, an integrated, commercially available NGS assay for the rapid and simultaneous detection of single nucleotide variants, short insertions and deletions, copy number variations, and gene rearrangements in 52 cancer genes with therapeutic relevance, but with 5 additional genes: the homologous recombination repair (HRR) genes BRCA1, BRCA2, ATM and CHEK2 that determine tumor sensitivity to inhibitors of the PARP enzyme and also KDR, which determines sensitivity to regorafenib. Twenty-five diagnostic samples of formalin-fixed, paraffin-embedded material submitted for molecular testing over a 8-month time period were analyzed so far. All patients had advanced solid tumors already refractory to conventional systemic therapy. Libraries were prepared from isolated nucleic acids and sequenced on the Ion Torrent S5 sequencer. Sequencing datasets were analyzed using the Ion Reporter software. From the samples of the 39 patients tested, we found 30 potential therapy target pathogenic gene aberrations in 22 (56.4%) patients: KRAS - 7 (23.3%), BRCA1 - 6 (20%), BRCA2 - 5 (16.6%), PIK3CA - 3 (10%), MAP2K1 - 2 (6.6%), BRAF-V600E - 2 (6.6%) mutations; and also one of each: ERBB2 (3.3%), mTOR (3.3%), KIT (3.3%), ALK (3.3%) mutations and one (3,3%) CCND1 amplification. In 3 (7,69%) patients there were double mutations: BRCA1 and BRCA2 in 2 cases and BRCA2 and KRAS and one case. The Oncotarget workflow enabled a turnaround of 18 frac12 days. Taken together, ONCOTARGET was found to be a convenient tool for fast, reliable, broadly applicable and cost-effective targeted NGS of tumor samples in routine diagnostics and therapeutic decisions with a potential to become an important assay for precision oncology in Brazil. Citation Format: Andre M. Murad, Jose Claudio Casali-da-Rocha, Juliana G. Carneiro, Ana L. Godard. ONCOTARGET (ONCOALVO): A custom NGS panel for therapeutic decision in solid tumors refractory to conventional therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3991.
BOOK REVIEWS
Authors: D. ROSENBLUM
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article BOOK REVIEWS Get access Empathy and the Practice of Medicine Howard Spiro , Mary G. McCrea Curnen , Enid Peschel , Deborah St. James , eds. New Haven : Yale Univ. Press , 1993 . 208 pp. $20.00. ISBN 0-300-05840-3 DANIEL ROSENBLUM, M.D. DANIEL ROSENBLUM, M.D. 10400 Connecticut Ave., Suite 606 Kensington, MD 20895 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 11, 1 June 1994, Pages 863–864, https://doi.org/10.1093/jnci/86.11.863 Published: 01 June 1994
Human Antihemophilic Factor: Preparation in a Hospital of a Concentrate for Clinical Use
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3794: Long-term Effects Of An Aerobic Training Program On Exercise Tolerance And Quality Of Life In Patients With Chronic Heart Failure. A Randomised Controlled Trial
Authors: Birgitta Blakstad Nilsson, Arne Westheim, May Arna Risberg
Journal: Circulation (2007)

Introduction : Exercise training has been shown to improve exercise tolerance (ET) and quality of life (QoL) in patients with chronic heart failure (CHF). However, the long-term effects of training programs are very spare. We hypothesized that a 4 months group-based aerobic interval-training program would improve ET and QoL in patients with CHF, and after follow-up without supervised exercise training. Methods : Eighty consecutive patients with stable CHF (mean age 70 ± 7.9 years, 63 males), in New York Heart Association-class II-IIIB were randomized to training (n=40) and control (n=40). The ejection fraction was 30.2 % ± 7.6 in the training group and 30.8% ± 9.4 in the control group. All were on optimal medical treatment (93% on beta-blockers and 98% on ACEI inhibitors or A2 receptor blockers at baseline). The training group exercised in a group-based aerobic interval-training model for 50 min, two times a week for 16 weeks. For the next 8 months they only got individual advices to exercise on their own. During the exercise period the patients had 4 consultations with a CHF nurse, including diatory advices, medication adherences, symptom monitoring and social support. In the follow-up period, the patients had 2 consultations with a CHF nurse. The control group received standard medical treatment without additional exercise training. The effects were evaluated by: bicycle ergometer test; 6-minute walk test and Minnesota Living with Heart Failure Questionnaire. Results: After 4 months, both exercise time (+19.2%, p=0.001), workload (+14%, p=0.001) and walking distance (+18%, p&lt;0.001) had increased significantly in the exercise group without any change in the control group. QoL showed a significant improvement (p&lt;0.05), with a mean difference of -12.1 points in the exercise group and no difference in the control group. After 12 months the differences were still significant for all parameters (exercise time, +19.8%, p=0.003, work load; +16%, p=0.001, walking distance; +17%, p&lt;0.001) and QoL with a mean difference of -11.7 points in the exercise group and +5.2 in the control group, p=0.002. Conclusions: Our results support the implementation of a group-based aerobic interval-training program, to improve both ET and QoL in patients with CHF.
Kleine Chirurgie.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"KOCH CONSUMPTION CURE" AND NEWSPAPER ADVERTISING.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal