tbuckley/cabot-search huggingface dataset:
Erratum for the Research Article: “In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma” by E. I. Galanzha, Y. A. Menyaev, A. C. Yadem, M. Sarimollaoglu, M. A. Juratli, D. A. Nedosekin, S. R. Foster, A. Jamshidi-Parsian, E. R. Siegel, I. Makhoul, L. F. Hutchins, J. Y. Suen, V. P. Zharov
Journal: Science Translational Medicine (2019)
Update: Respiratory Syncytial Virus Activity--United States, 1997-98 Season
Journal: JAMA (1998)

Respiratory syncytial virus (RSV), a common cause of winter outbreaks of acute respiratory disease, results in an estimated 90,000 hospitalizations and 4500 deaths each year from lower respiratory tract disease among infants and young children in the United States. Outbreaks occur annually throughout the country. RSV activity in the United States is monitored by the National Respiratory and Enteric Virus Surveillance System (NREVSS), a voluntary, laboratory-based system. This report summarizes trends in RSV reported by NREVSS for July 1992-June 1997 and presents provisional surveillance results for July-November 1997. These data indicate onset of widespread RSV activity for the 1997-98 season.
Editorial: Intravascular factors in diabetic retinopathy
Authors: S. Vaisrub
Journal: JAMA (1975)

Not all vascular complications of diabetes are specific to this disease. Atherosclerosis of the coronary arteries in diabetic patients does not differ from that in the nondiabetic; it is merely more frequent. Specific, however, are the changes in the microvasculature. It is therefore not surprising that much attention has centered on these changes in diabetic retinopathy. Some of this attention is being currently diverted from vessel wall to vessel content, particularly to the fibrinolytic and clotting systems. It is becoming increasingly apparent that fibrinolytic activity and platelet aggregation may play an important pathogenetic role in the capillary closure,<sup>1</sup>which is one of the earliest manifestations of diabetic retinopathy. The fibrinolytic system is a defensive mechanism against vascular occlusion by platelet plugs and subsequent clots. Paul and Adlakha<sup>2</sup>found this activity to be decreased in two patients with diabetic retinopathy. Fukuda<sup>3</sup>reported similar observations in diabetic patients with
Recurrences and sequelae of rheumatic fever in Nashville. A follow-up study
Authors: R. W. Quinn
Journal: JAMA (1977)

A follow-up study of 311 patients who acquired rheumatic fever in Nashville, Tenn, during the period from 1963 to 1969 showed that 53% took penicillin prophylaxis regularly, 36% did not take it as recommended, and 11% did not take it at all. There were no recurrences among those who received prophylaxis by injection regularly, six recurrences among those who took oral prophylaxis regularly, and no recurrences among 45 subjects who did not take prophylaxis. Among these 45, however, were 29 for whom prophylaxis was not recommended by their physicians. The original study indicated that the incidence of acute rheumatic fever among blacks was twice as high as among whites. In the present study, incidence of rheumatic heart disease and recurrences was substantially higher among blacks than among whites. (<i>JAMA</i>238:1512-1515, 1977)
Therapy with orchiectomy or estrogens or both
Authors: H. Brendler
Journal: JAMA (1969)

Since its introduction in 1941 by Huggins and Hodges,<sup>2</sup>androgen-control therapy has been found effective initially in about 70% to 80% of cases of advanced prostatic cancer. Just why the remainder do not respond is unclear. The typical remission is characterized by prompt relief of bone pain and lessening of urinary-tract symptoms. Objective changes include dramatic regression in the primary prostatic growth and return of elevated serum acid phosphatase (SAP) levels to normal. Changes in bone metastases (usually osteoblastic) occur commonly, but are difficult to evaluate radiologically. The metastases may disappear entirely and be replaced by new bone. Osteolytic metastases are not seen as infrequently as in breast cancer; with healing, these also are replaced by new bone. Enlargement of inguinal, femoral, and intra-abdominal lymph nodes usually decreases perceptibly, sometimes completely. Changes in serum alkaline phosphatase levels are not consistent. In many cases, the serum alkaline phosphatase level rises
THE CLINIC.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemoptysis with cavitary lung lesion
Authors: D. Odero
Journal: JAMA (1976)

<h3>History</h3> A 27-year-old woman was admitted to the hospital for hemoptysis of three days' duration. During the previous three years, she had experienced progressive dyspnea on exertion and intermittent left-sided pleuritic chest pain. A posteroanterior chest roentgenogram (Fig 1) was obtained, followed by lateral tomography of the left side of the chest (Fig 2). <h3>Diagnosis</h3> Cavitary sarcoidosis with pulmonary aspergilloma. <h3>Comment</h3> The chest roentgenogram (Fig 1) shows diffuse bilateral lesions. Small nodular lesions are present throughout the right lung and left base. There is a large cavity in the left upper lung zone with considerable overlying pleural thickening. The lateral tomogram (Fig 2) shows a rounded mass about 3 cm in diameter surrounded by a radiolucent zone, representing a mass in a cavity. Three years prior to this admission, sarcoidosis was diagnosed on the basis of bilateral hilar adenopathy, diffuse small nodular infiltrates on the chest roentgenogram, and a cervical
BOOK REVIEWS
Authors: J. P. EDER
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Recent Concepts in Sarcoma Treatment. James R. Ryan, Laurence O. Baker, eds. Dordrecht, The Netherlands: Kluwer Academic Publishers, 1988, 327 pp. $94.00. JOSEPH PAUL EDER JOSEPH PAUL EDER Department of Medicine Beth Israel Hospital330 Brookline Avenue Boston, MA 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 5, 1 March 1989, Pages 375–376, https://doi.org/10.1093/jnci/81.5.375-a Published: 01 March 1989
Family and community medicine in a general hospital. Putting principles to work
Authors: N. J. Zervanos
Journal: JAMA (1972)

Family and community medicine is viewed as the effective concept and organizational vehicle through which comprehensive health care can be realized. The application of several principles of comprehensive health care is illustrated by the Family and Community Medicine Program at the Lancaster General Hospital in Lancaster, Pa. This program has successfully marshalled the support and cooperation of individuals and groups from both public and private sectors. Our hospital offers a three-year Residency Program in Family and Community Medicine.
Musical Bumps
Authors: D. G. Ross
Journal: BMJ (1974)

<h3>Abstract</h3> Graphical neural networks (GNNs) offer the opportunity to provide new insights into the diagnosis, prognosis and contributing factors of Alzheimer’s disease (AD). However, previous studies using GNNs on AD did not incorporate tau PET neuroimaging features or, more importantly, have applied class labels based only on clinician diagnosis, which can be inconsistent. This study addresses these limitations by applying cluster-based labelling on heterogeneous data, including tau PET neuroimaging data, before applying GNN for classification. The data comprised sociodemographic, medical/family history, cognitive and functional assessments, apolipoprotein E (APoE) ε4 allele status, and combined tau PET neuroimaging and MRI data. We identified 5 clusters embedded in a 5-dimensional nonlinear UMAP space. Further projection onto a 3-dimensional UMAP space for visualisation, and using association rule and information gain algorithms, the individual clusters were revealed to have specific feature characteristics, specifically with respect to clinical diagnosis of AD, gender, parental history of AD, age, and underlying neurological risk factors. In particular, there was one cluster comprised mainly of clinician diagnosis of AD. We re-labelled the diagnostic classes based around this AD cluster such that AD cases occurred only within this cluster while those AD cases outside of it were re-labelled as a prodromal stage of AD. A post-hoc analysis supported the re-labelling of these cases given their similar brain tau PET levels, lying between those of the remaining AD and non-AD cases. We then trained a GNN model using the re-labelled data and compared the AD classification performance to that trained using clinician diagnostic labels. We found that GNN with re-labelled data had significantly higher average classification accuracy (p=0.011) and less variability (93.2±0.03%) than with clinician labelled data (90.06±0.04%). During model training, the cluster-labelled GNN model also converged faster than that using clinician labels. Overall, our work demonstrates that more objective cluster-based labels are viable for training GNN on heterogeneous data for diagnosing AD and cognitive decline, especially when aided by tau PET neuroimaging data.
By-line Incomplete
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2017)

In patients recovering from surgery, the goals of mechanical ventilation are to open collapsed alveoli and improve gas exchange while minimizing barotrauma to the lungs.This single-center randomized clinical trial by Leme and colleagues randomized 320 patients requiring mechanical ventilation after cardiac surgery to undergo lung infl ation maneuvers at higher vs lower airway pressures to recruit alveoli while maintaining a low tidal volume to minimize barotrauma.The patients who received lung infl ation at higher pressures had less severe pulmonary complications.In an Editorial, Neto and Schultz discuss the benefi ts and harms of ventilation strategies for patients with severe lung injury.
Interferon-α receptor expression and regulation in chronic hepatitis B virus infection
Authors: J Lau
Journal: Hepatology (1991)

Interferon-α elicits antiviral and immunoregulatory activities by binding to specific receptors on the cell surface. In this study, binding characteristics of interferon-α to peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection were studied using radioiodinated recombinant interferon-α2b to determine interferon-α receptor numbers and dissociation constants. A single class of interferon-α receptor was demonstrated on peripheral blood mononuclear cells and mononuclear subsets. Peripheral blood mononuclear cells from patients with chronic hepatitis B virus infection (n = 20) and controls (n = 16) expressed a similar number of interferon-α receptors (484 ± 175 vs. 511 ± 168 sites/cell respectively, p = NS) with a similar dissociation constant (dissociation constant ± 0.2 to 0.7 nmol/L). Expression of interferon-α receptors was similar in monocyteenriched and lymphocyte-enriched fractions in both groups. Similar changes were observed in patients receiving α-interferon therapy. There was no correlation between interferon-α receptors expression and serum transaminase, serum HBsAg, serum HBV DNA, liver histological findings or the response to interferon-α therapy. After incubation of lymphocytes in vitro with interferon-α2b (10 to 1,000 U/ml), interferon-α receptors number dropped by 42% to 80%, but this was associated with an increase in binding affinity (dissociation constant ≈︁ 0.05 to 0.15 nmol/L) in both patients and controls. There was significant delay in the initial phase of receptor recovery in the patients with chronic hepatitis B virus infection compared with normal controls (days 1 and 2, p <0.05). These data indicate that interferon-α receptors are expressed and regulated normally in chronic hepatitis B virus infection and that the variable response to interferon-α therapy is not due to a variation in interferon-α receptor. The increase in binding affinity on interferon-α therapy may be one factor explaining why long-term interferon-α therapy is effective despite a decrease in receptor number. (HEPATOLOGY 1991;13:332–338).
Children's Health, Susceptibility, and Regulatory Approaches to Reducing Risks from Chemical Carcinogens
Authors: Gail Charnley, Resha M. Putzrath
Journal: Environmental Health Perspectives (2001)

Risk-based regulation of chemical exposures from the environment generally relies on assumptions about the extent of people's susceptibility to chemically induced diseases. Those assumptions are intended to be health-protective; that is, they err on the side of overstating susceptibility. Recent concern about children's special susceptibilities has led to proposals that would make risk-based regulations one-tenth more stringent, unless data are available to refute the assumption that children are more susceptible than adults. In this paper we highlight some of the questions that should be addressed in the context of risk assessment to determine whether such increased stringency would accomplish the desired result of improving children's health. In particular, characterizing benefits of greater stringency requires more information about dose-response relationships than is currently available. Lowering regulatory levels has attendant costs but may not achieve benefits, for example, if the previous level were already below an actual or practical threshold. Without an ability to understand the potential benefit (or lack thereof) of the additional stringency, an appropriate consideration of benefits and costs is not possible.
Control of tumor suppressor protein PTEN by dimethlysulfoxide in HL-60 cells
Authors: J. Park, Y.-R. Lee, H.-J. Shim, H.-W. Rho, J.-W. Park, M.-K. Han, E.-C. Jhee, M. H. Lee, K. Park, J.-S. Kim
Journal: Journal of Clinical Oncology (2004)

3156
Phosphoribosyltransferase Deficiency Gout
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OLD-TIME MEDICAL AND SURGICAL ANTICIPATIONS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preliminary Report: Foodborne Outbreak of Escherichia coli O157:H7 Infections From Hamburgers—Western United States, 1993
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amyloid
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Protective effect of the lazaroid U74006F in cold ischemia-reperfusion injury of the liver
Authors: C Cosenza
Journal: Hepatology (1994)

Lipid peroxidation may play a major role in the loss of liver graft viability after prolonged cold ischemia and reperfusion injury. The lazaroid compound U74006F is a potent inhibitor of lipid peroxidation, and this study was designed to evaluate the efficacy of this compound in preventing cold ischemia–reperfusion damage in three different models: pig endothelial cells in culture, ex vivo isolated pig liver perfusion and orthotopic transplantation of syngeneic rat livers. The addition of U74006F to University of Wisconsin preservation solution significantly prolonged endothelial cell viability after 48 and 72 hr of cold ischemia and reoxygenation (p < 0.01). Donor pigs were injected with vehicle or U74006F (4.5 mg/kg) before liver harvest. After 24 hr of cold storage in University of Wisconsin solution, the livers were perfused with pig blood for 180 min in an isolation chamber. Measurements of liver function parameters, including AST, ALT, bile production, superoxide anion and phospholipase A2 release, were assessed every 60 min. Although bile production was similar in the U74006F-treated and control groups, significant decreases of AST and ALT levels (p < 0.01) in the perfusate of the livers from treated donors were observed. In addition, the U74006F group displayed significantly reduced release of superoxide anion and phospholipase A2 compared with these parameters in the untreated group (p < 0.05 and p < 0.01, respectively). In the last model, donor rats were treated with U74006F before harvest; the rat liver grafts were preserved in cold University of Wisconsin solution for 24 hr and then transplanted into recipient rats. The number of liver graft recipients that survived 7 days after transplantation was significantly larger (p < 0.001) in the group of recipients of U74006F-treated livers. Furthermore, this group showed significantly lower levels of lipid peroxides in liver tissues (p < 0.01) and AST and ALT release (p < 0.05) compared with the control group at 2 and 7 days after transplantation. We conclude that U74006F is effective in enhancing the resistance of the liver to damage due to cold ischemia–reperfusion injury and that the use of this compound may improve early liver graft function after transplantation. (Hepatology 1994;19:418–425).