tbuckley/cabot-search huggingface dataset:
Cholestasis and rubeola
Authors: G. Pelletier
Journal: JAMA (1983)

<h3>To the Editor.—</h3> I congratulate Drs Wray and Friedland for their excellent study of the quality of physical examination performed by house staff and interns (1983;249:1035). Their work highlights the concept of teaching the art of medicine at the bedside, which was preached in 1883 by Oliver Wendell Holmes on this side of the Atlantic when he wrote the following: "The most essential part of a student's instruction is obtained, as I believe, not in the lecture room, but at the bedside. Nothing seen there is lost; the rhythms of disease are learned by frequent repetition, its unforeseen occurrences stamp themselves indelibly in the memory."<sup>1</sup> Their estimates of the time needed to review findings at the bedside ranged between 12 and 12 1/2 minutes per patient. Lack of time, therefore, should not be an excuse by "too busy" physicians for not performing a sound physical examination. Kampmeier wrote that
An Invitation from the College to Young Men and Women
Authors: E. J. H.
Journal: Annals of Internal Medicine (1969)

Editorial Notes1 November 1969An Invitation from the College to Young Men and WomenE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-5-1024 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt a rate of annual dues only slightly higher than that for the student and house officer subscription to the ANNALS, trainees in internal medicine can join the American College of Physicians in a new class of membership—candidate membership. This privilege was proposed by the Board of Regents 1 year ago and then approved by vote of the Fellows of the College at the Annual Business Meeting in Chicago last April.Candidate membership is available to men and women, graduates of medical schools acceptable to the College, who have finished at least 2 years of postdoctoral training in internal medicine... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1969Volume 71, Issue 5_Part_1Page: 1024-1024KeywordsGraduate medical education ePublished: 1 December 2008 Issue Published: 1 November 1969 PDF downloadLoading ...
Prostatic Carcinogenesis Evoked by Cellular Interaction
Authors: Leland W. K. Chung, Shi-Ming Chang, Carol Bell, Haiyen Zhau, Jae Y. Ro, Andrew C. von Eschenbach
Journal: Environmental Health Perspectives (1988)

Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.
Abstracts of the 29th Annual Conference of the International Society for Environmental Epidemiology (ISEE), 24-28 September 2017, Sydney, Australia
Journal: Environmental Health Perspectives (2017)

The 29th Annual Scientific Conference of the International Society for Environmental Epidemiology was held 24–28 September 2017 in Sydney, Australia. The conference theme was "Healthy Places, Healthy People—Where Are the Connections?" The focus of this year's conference was the recognition that there are many different places (the natural environment, the built environment, and the social environment) and many different people (the young, the old, the disadvantaged, and the marginalized), and that the connections between them may be physical, psychological, social, or political.
SARS-CoV-2 Transmission and the Risk of Aerosol Generating Procedures
Authors: Susan Pasnick, W. Graham Carlos, Charles S Dela Cruz, Jane E. Gross, Garth Garrison, Shazia Jamil
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

"SARS-CoV-2 Transmission and the Risk of Aerosol Generating Procedures." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Reply
Authors: J R Thornton, M S Losowsky
Journal: Gut (1992)

<h3>Abstract</h3> Generating synthetic locomotory and electrophysiological data is a useful yet cumbersome step commonly required to study theoretical models of the brain’s role in spatial navigation. This process can be time consuming and, without a common framework, makes it difficult to reproduce or compare studies which each generate test data in different ways. In response we present RatInABox, an open-source Python toolkit designed to model realistic rodent locomotion and generate synthetic electrophysiological data from spatially modulated cell types. This software provides users with (i) the ability to construct one- or two-dimensional environments with configurable barriers and rewards, (ii) a realistic motion model for random foraging fitted to experimental data (iii) rapid online calculation of neural data for some of the known self-location or velocity selective cell types in the hippocampal formation (including place cells, grid cells, boundary vector cells, head direction cells) and (iv) a framework for constructing custom cell types as well as multi-layer network models. Cell activity and the motion model are spatially and temporally continuous and topographically sensitive to boundary conditions and walls. We demonstrate that out-of-the-box parameter settings replicate many aspects of rodent foraging behaviour such as velocity statistics and the tendency of rodents to over-explore walls. Numerous tutorial scripts are provided, including examples in which RatInABox is used for decoding position from neural data, reinforcement learning, or to set up an example circuit capable of learning path integration. We hope this tool significantly streamlines the process of theory-driven research into the brain’s role in navigation.
Distant Healing
Authors: John Astin, Elaine Harkness, Edzard Ernst
Journal: Annals of Internal Medicine (2001)

Letters20 March 2001Distant HealingJohn Astin, PhD, Elaine Harkness, BSc, and Edzard Ernst, MD, PhDJohn Astin, PhDUniversity of Maryland School of Medicine; Baltimore, MD 21136 (Astin)University of Exeter; EX2 4NT Exeter, United Kingdom (Harkness, Ernst)Search for more papers by this author, Elaine Harkness, BScUniversity of Maryland School of Medicine; Baltimore, MD 21136 (Astin)University of Exeter; EX2 4NT Exeter, United Kingdom (Harkness, Ernst)Search for more papers by this author, and Edzard Ernst, MD, PhDUniversity of Maryland School of Medicine; Baltimore, MD 21136 (Astin)University of Exeter; EX2 4NT Exeter, United Kingdom (Harkness, Ernst)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-6-200103200-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We continue to stand by what we feel is a reasonably cautious and conservative interpretation of the findings. Because 57% of the trials we examined did show a significant effect on at least one outcome (and the overall pooled effect size was significant), we do feel that, at a minimum, additional research should be carried out in these areas. While it is true that the results were not uniformly positive, the mathematical odds (based on a simple binomial test) that 13 of 23 studies would show a significant treatment effect (Pï¿½<ï¿½0.05) are greater than 1 in a million. ...References1. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. . Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1-12. [PMID: 0008721797] CrossrefMedlineGoogle Scholar2. Harris WS, Gowda M, Kolb JW, Strychacz CP, Vacek JL, Jones PG, et al. . God, prayer, and coronary care unit outcomes: faith vs works? Arch Intern Med. 2000;160:1877-8. [PMID: 0010871999] CrossrefMedlineGoogle Scholar3. Dossey L. Prayer and medical science: a commentary on the prayer study by Harris et al and a response to critics. Arch Intern Med. 2000;160:1735-7. [PMID: 0010871965] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Maryland School of Medicine; Baltimore, MD 21136 (Astin)University of Exeter; EX2 4NT Exeter, United Kingdom (Harkness, Ernst) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Efficacy of “Distant Healing” John A. Astin , Elaine Harkness , and Edzard Ernst Distant Healing Kevin Courcey Distant Healing Ted J. Kaptchuk Metrics Cited ByNegotiating Integrative Medicine: A Framework for Provider-Patient ConversationsComplementary and Alternative Medicine and the Need for Evidence-based Criticism 20 March 2001Volume 134, Issue 6Page: 533KeywordsHomeopathyScientistsTouch ePublished: 20 March 2001 Issue Published: 20 March 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Comparaison de la macrodilatation papillaire endoscopique avec ou sans sphinctérotomie endoscopique pour le traitement des calculs biliaires cholédociens larges
Journal: Endoscopy (2019)

La macrodilatation papillaire endoscopique (MD) sans sphinctérotomie endoscopique préalable (SEB) donne d'excellents résultats pour le traitement des calculs biliaires de la voie biliaire principale (VBP).
Irreversible coronary occlusion and ergonovine.
Authors: T O Cheng
Journal: Circulation (1982)

over distance significantly increased the correlation of SV 1 vs left ventricular (LV) mass (r = 0.60 to 0.71).This improvement is similar to our finding using the distance correction with the sum of SVI and RV5 or 6 vs LV mass (r = 0.68 to 0.84, p < 0.005) for a similar population.2However, we believe the formula used to derive this improvement is presented in error in their table 6.To correct for voltage attenuation over distance, the voltage should be multiplied, not divided, by the square of the left ventricle to recording electrode distance.We feel that their demonstration that echo is a better in- dicator of LV mass than ECG voltage (even with corrections for voltage attenuation over distance) is a most important observation.
Adjuvant chemotherapy.
Authors: S K Carter
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.8.1154 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3894590 Adjuvant chemotherapy. S K CarterxS K CarterSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.8.1154 PDF "Adjuvant chemotherapy.." Journal of Clinical Oncology, 3(8), pp. 1154–1155© 1985 by American Society of Clinical Oncology
CONSORT statement: extension to cluster randomised trials
Authors: Marion K Campbell, Diana R Elbourne, Douglas G Altman
Journal: BMJ (2004)

Reports of cluster randomised trials require additional information to allow readers to interpret them accuratelyThe effective reporting of randomised controlled trials has received useful attention in recent years.Many journals now require that reports conform to the guidelines in the Consolidated Standards of Reporting Trials (CONSORT) statement, first published in 1996 1 and revised in 2001. 2 The statement includes a checklist of items that should be included in the trial report.These items are evidence based whenever possible and are regularly reviewed. 3 The statement also recommends including a flow diagram to show the flow of participants from group assignment through to the final analysis.The CONSORT statement focused on reporting parallel group randomised trials in which individual participants are randomly assigned to study groups.However, in some situations it is preferable to randomly assign groups of individuals (such as families or medical practices) rather than individuals.Reasons include the threat of contamination of some interventions (such as dietary interventions) if individual randomisation is used. 4 5Also, in certain settings randomisation by group may be the only feasible method of conducting a trial. 6Trials with this design are variously known as field trials, community based trials, place based trials, or (as in this paper) cluster randomised trials. 7In an earlier discussion paper we considered the implications of the CONSORT statement for the reporting of cluster randomised trials. 8Here we present updated guidance, based on the 2001 revision of the CONSORT statement.
Ampicillin: Activity in Vitro and Absorption and Excretion in Normal Young Men
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Officers of the American Medical Association.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3252: Thoracoscopic Epicardial Pulmonary Vein Isolation Is A Realistic Alternative For Endocardial Radiofrequency Ablation: Lower Risk Of Arterial Embolism And Shorter Procedure Times
Authors: Loes Sauren, Mark la Meir, Laurent Pison, Luc De Roy, Erik van der Veen, Werner Mess, Harry Crijns, Jos Maessen
Journal: Circulation (2007)

Background Pulmonary veins isolation (PVI) has become an established treatment for atrial fibrillation (AF). However, post-procedural complications by cerebroembolic events might occur. In order to evaluate the cause of these complications we compared the number of cerebral microemboli during two approaches of PVI; epicardial microwave ablation and percutaneous endocardial radiofrequency ablation in patients with AF. Methods and Results Eight patients underwent a right 3 port mono-lateral thoracoscopic epicardial microwave (MW) ablation on the beating heart of the 4 pulmonary veins and the posterior left atrium. Twelve patients underwent endocardial RF ablation of the 4 pulmonary veins. Transcranial Doppler was used in all patients to detect cerebral MES. There was no significant difference in total ablation time between the two groups. However, the total procedural time was significant longer in the percutaneous endocardial PVI approach. Stroke or CVA was not reported in any of the patients. The average of 4 (± 7) cerebral MES per patient during the epicardial ablation is highly significantly lower than the 2703 (± 1919) cerebral MES during percutaneous endocardial RF ablation. Conclusion Cerebral MES were almost absent during thoracoscopic epicardial microwave ablation for the treatment of AF. This finding is in sharp contrast with the abundant MES detected during percutaneous endocardial RF ablation. Due to a positive association between the number of MES and cerebral complications, the striking difference of the amount of MES and the absence of thrombus formation might indicate a comparatively low risk of cerebrovascular complications for the epicardial approach as compared to the percutaneous approach. Since the success rates of both PVI approaches is reported to be around 80%, the shorter procedural time and the absence of cerebral MES render the thorascopic epicardial microwave approach a realistic alternative for endocardial RF ablation. Number of MES during both PVI approaches
Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate?
Journal: BMJ (1982)

Cimetidine 1 g daily is often continued for a fixed period beyond the time of healing of duodenal ulcer on the assumption that it might reduce the subsequent relapse rate.To test this, 194 patients whose ulcers had healed after one month of cimetidine 1 g daily were allocated at random to three groups for further treatment with cimetidine 1 g daily for two months (n -63) or five months (n 66) or placebo (n = 65).Thereafter all patients received placebo.Endoscopy was done routinely every three months, or earlier if symptoms recurred.During follow-up in the placebo phase, which lasted for up to 25 months, the estimated total proportions of patients in the three groups with symptomatic recurrences of ulcer were 80%, 90%, and 77%, respectively; the corresponding proportions with silent plus symptomatic relapses were 92%, 90%, and 100%.The relapse rates were also similar in all three groups.Statistical analysis showed a significant variation in relapse rate but the differences were regarded as clinically unimportant.These findings show that full-dose cimetidine con- tinued for several months beyond the time of healing of duodenal ulcer does not decrease the risk of subsequent relapse.
EXCISION OF BENIGN PIGMENTED MOLES
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of an Influenza Virus Vaccine, Bivalent (Types A2 and B)
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urinary hexagons
Authors: L. B. Berman
Journal: JAMA (1974)

CYSTINURIA is an uncommon, easily diagnosable, and treatable disease. The latter two points make it a matter of interest to the practicing physician. We may define the disorder from the point of view of the nephron and from that of the patient. Present concepts hold that a congenital defect of kidney function prevents proper reabsorption by the proximal tubular epithelium of cystine, lysine, ornithine, and arginine. The solubility of cystine is such that crystallization and stone formation may occur. Other nephron functions, such as glomerular filtration, tubular reabsorption, and secretion of various solutes are intact. Clinically, a young person is seen with recurrent, radiopaque stones and no other problems. The diagnosis may be made in several ways, including microscopic examination of urine. It is this point whence the title of this discussion takes its name. Cystine crystals are hexagonal. Virtually<i>no other urine crystal is so shaped</i>. Second, crystals are
Early syphilis with liver involvement
Authors: D. S. Keisler
Journal: JAMA (1982)

SECONDARY syphilis of the liver is a treatable disease that may have unusual manifestations. Often, the disease is difficult to diagnose, requiring expensive testing and delaying initiation of therapy.<sup>1-4</sup>The finding of a spirochete on liver biopsy is diagnostic, but rare; only two authors have published photographic documentation of spirochetes in the liver.<sup>5,6</sup>Other less-invasive test results may also suggest secondary involvement of the liver. We describe a patient with typical serological and laboratory findings who was treated successfully for secondary syphilis of the liver after a biopsy specimen disclosed a rare spirochete in the portal tracts. <h3>Report of a Case</h3> A 27-year-old homosexual man was admitted to the hospital for evaluation of epigastric pain and elevated serum alkaline phosphatase levels. Ten days earlier, he had had dull, intermittent epigastric pain that was exacerbated by eating and bending over. He denied nausea, vomiting, jaundice, or fever. He had