tbuckley/cabot-search huggingface dataset:
Effect of Anesthesia on Cardiac Excitability Produced by Single Pulse Electrical Stimulation: Experimental Study
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DERMATOMYOSITIS
Authors: LOUIS G. HEYN
Journal: JAMA (1924)

Dermatomyositis, or nonsuppurative myositis, is a severe, generalized, inflammatory disease of the voluntary muscles, accompanied by certain characteristic changes in the skin. The comparative rarity of the disease prompts the publication of this case history. <h3>REPORT OF CASE</h3><h3>History.</h3> —J. G., a colored laborer, aged 35, entered the South Medical Service of the Cincinnati General Hospital, July 20, 1923, complaining of dull, aching pains in the neck and in all four extremities, aggravated by any movement of these parts. He stated that, four weeks previous to admission, after working for seven hours in a heavy rain, he had awakened the following morning with a stiffness of the entire body, and was unable to work for two days. He then attempted to work again, but could not do so on account of the increasing discomfort on moving. This discomfort was especially marked in the neck and shoulders, increasing in intensity toward
BOOK REVIEWS
Authors: G. B. GORDON
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Progress in Clinical and Biological Research, Volumes 340A-340E: Basic Mechanisms; Metabolism, Testing Methods, and Chromosomes; Somatic and Heritable Mutation, Adduction, and Epidemiology; Car-cinogenesis; Environmental Genotoxicity, Risk, and Modulation . Mortimer L. Mendelsohn , Richard J. Albertini , eds. New York : Wiley &Liss , 1990 , $110 each. GARY B. GORDON GARY B. GORDON Laboratory for Molecular Pharmacology, Johns Hopkins University, School of Medicine725 N. Wolfe St., Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 12, 19 June 1991, Page 876, https://doi.org/10.1093/jnci/83.12.876 Published: 19 June 1991
Tropical Fevers
Authors: J. Bird
Journal: BMJ (1849)

Then gradually the quantity of Cholera fluid lessens, and finally, bile pigment appears, and the stools lose altogether the Choleaic character.Want of space compels me to dismiss these most important topics, with dication merely of the chief points of interest.I hope on a f fuifoccasion, to be able to adduce additional facts in corroboration, or l$ification of my views, and to enter more fully into the question of t1s relation of the individual elements of the Cholera dejections, to thfgeneral phenomena of the disease.I5ONTRIBUTIONS TO THE PATHOLOGY AND TREATMENT OF TROPICAL FEVERS.
THERAPEUTIC RELATIVITY
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE RELATION OF DISEASE OF THE ACCESSORY CAVITIES TO OPHTHALMOLOGY.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dietary sodium restriction for mild hypertension in general practice
Authors: G. A MacGregor, N. D Markandu, S. J Smith
Journal: BMJ (1983)

that smoking tends to depress the appetite as well as the sense of taste is common knowledge among persons who want to lose weight.When I try, as I often do, to persuade people to stop smoking common responses are: "But I am afraid of getting fat" and "When I don't smoke I am hungry all the time."Perhaps all this simply reflects compulsion for oral satisfaction, but the key to the inverse relation between smoking and relative weight seems to be much closer to the gastrointestinal tract than to the respiratory system.
Anesthesia Technique and Outcomes After Hip Fracture Surgery—Reply
Authors: Mark D. Neuman, Paul R. Rosenbaum, Jeffrey H. Silber
Journal: JAMA (2014)

In Reply Our study evaluated the association between anesthesia technique and outcome among patients with hip fracture, observing an indeterminate effect of anesthesia technique on 30-day mortality and a shorter inpatient length of stay with regional anesthesia.
Association of rurality and race with surgical treatment and outcomes for nonmetastatic colon cancer.
Authors: Niveditta Ramkumar, Carrie Colla, Sandra L. Wong, Qianfei Wang, Gabriel A. Brooks
Journal: Journal of Clinical Oncology (2021)

e18536 Background: Rural cancer patients face limited access to care due to greater travel distance and lack of specialty cancer care. Little is known about the intersection of rurality with well-documented racial disparities in colon cancer treatment and outcomes. Methods: We used fee-for-service Medicare claims to study patients age 65+ diagnosed with incident colon cancer without evidence of metastases who underwent cancer-directed surgery between 04/01/2016 and 09/30/2018. The primary exposure was rurality of patient’s residence categorized as metropolitan (metro), micropolitan, and small town/rural. Outcomes were non-elective surgery (emergency department visit or transfer within 2 days of surgery), receipt of minimally invasive surgery (laparoscopic or robotic), 90-day surgical complications, and 90-day mortality. Logistic regression adjusted for patient demographics, cancer side (right vs left), comorbidities, and Area Deprivation Index. We assessed effect modification by race/ethnicity. Results: Of 57,710 patients with incident non-metastatic colon cancer, 37,691 (65%) underwent surgery. In this surgical cohort, small town/rural and micropolitan residents were more likely to be older, white, and Medicare-Medicaid dual-eligible than metro residents. After risk adjustment, patients in small town/rural areas had higher odds of non-elective surgery (OR=1.24, 95% CI:1.13-1.36) and lower odds of minimally invasive surgery (OR=0.75, 95% CI:0.71-0.80) than patients living in metro areas. Similar results were seen for micropolitan areas. The association between rurality and 90-day outcomes differed by race/ethnicity (p-interaction=0.001 for surgical complications and mortality, see Table). Hispanics and other races had higher odds of 90-day surgical complications in non-metro versus metro areas but there was no notable difference for white patients. Likewise, compared to metro areas, racial/ethnic minorities had higher odds of 90-day mortality in small town/rural areas but white patients had lower odds. Conclusions: Small town/rural-residing Medicare beneficiaries undergoing surgery for non-metastatic colon cancer were less likely to receive optimal surgical management and worse outcomes, especially among non-white patients. The compounded effect of sociodemographic factors should be further studied to develop targeted policies and improve care for rural cancer patients.[Table: see text]
TURKISH BATH IN MEDICINE.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shifts in Medicaid Coverage for Smoking Cessation Treatment
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Palliative and supportive care / Psychological aspects
Authors: C Bohas, Y Gadiolet, J Ranchere, E Blondet, H Lacroie, Y Merrouche, P Rebattu, Pater Xl, Chac6n Ji, M Gonzalez Bar6n, Sanchez Jj, Garcia Gir6n C, Ord6nez, Garcia De Paredes
Journal: Annals of Oncology (1992)
Rate of Growth and Apparent Duration of Untreated Primary Bronchial Carcinoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Low-protein diets in chronic renal failure.
Journal: BMJ (1975)

While analysis of the amniotic fluid provides valuable information in some conditions there is sufficient cause for concern about its safety to limit its usefulness for the time being.Possibly the prior localisation of the placenta by ultrasound may prove to be unnecessary, but we still need to know the actual risk of rhesus sensitisation and to obtain more extensive experience with suprapubic amniocentesis in late pregnancy.
Medical Immunology
Authors: Noel Rose
Journal: JAMA (1978)

The rapid growth of immunology during the past years has led to a profusion of new textbooks, most of which have tried to cover the entire scope of immunology. The three authors of<i>Medical Immunology</i>, however, have perceived a gap owing to the absence of an early readable book devoted to the clinical applications of immunology. They have been able to fill the void with a useful book of manageable size. Immunology begins with the study of acquired resistance to infectious diseases, a subject that still occupies an important place in clinical immunology. These studies led to the realization that the immune response is a complex apparatus with built-in checks and balances. The physiological regulators sometimes go awry and cause disease or contribute to it. Most of the book is concerned with defects in immunologic regulation in the form of immunodeficiency diseases, immunoproliferative diseases, immune complex diseases, and autoimmune diseases.
The management of hypertension
Authors: G. N. Aagaard
Journal: JAMA (1973)

This report on the management of hypertension is presented as a part of the Drug Spotlight Program. We will attempt to answer two questions: "Who should be treated for elevated blood pressure?" and "How should hypertension be treated?" The diagnosis of specific causes of elevated blood pressure and the detailed pharmacology of antihypertensive drugs will not be considered. Life insurance data and epidemiologic studies show that increases of either systolic or diastolic blood pressure are associated with increased morbidity and mortality from cardiovascular, cerebrovascular, and renal disease. The Veterans Administration Cooperative Study<sup>1-3</sup>showed that drug therapy will drastically reduce complications and deaths. Unfortunately, most of the persons with hypertension in the United States are unaware of their hypertension, or are untreated. A recent study<sup>4</sup>showed that 58.9% of hypertensives found in a survey were previously undetected. As many as 16.4% of hypertensives had had diagnoses on earlier examinations,
Physiology of Bone: Mineral Compartment Proteins As Candidates for Environmental Perturbation by Lead
Authors: John J. Sauk, Martha J. Somerman
Journal: Environmental Health Perspectives (1991)

Termine et al. first demonstrated that sequential dissociative extraction and fractionation procedures with protease inhibitors could provide a convenient approach for the study of mineral compartment constituents. The primary extraction regimen used 4 M guanidine HCl to remove most of the protein from the nonmineralized phase of bone. Subsequently, EDTA-guanidine was used to remove the mineral-phase components. These methods discriminate on the basis of physical-chemical association with a mineral phase rather than on the specific gene products of a particular cell. In the present discussion emphasis is directed at a group of divalent cation binding proteins isolated from the mineral compartment of bone. The localization, synthesis, and chemical characteristics of osteonectin, bone sialoproteins I and II, and bone acidic glycoprotein-75 are discussed and offered as possible sites for perturbation by the environment with lead exposure.
The Law, Public Policy, and the Peddlers of Tobacco
Authors: Gale P. Largey
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The national health objectives for the year 2000 advocate the control of advertising and promoting sales of tobacco products to youth. Hasn't the time come for prohibiting smoking by youths? Shouldn't there be a legal age for smoking as there is for drinking? Why not legally proscribe the use of this dangerous and highly addictive drug? We recently conducted a telephone survery of 1518 randomly selected Pennsylvania adults and asked the question: "Currently, in Pennsylvania, there is a legal age for drinking. Would you favor or oppose having a legal age for smoking?"<sup>1</sup>By almost two to one (64%), respondents favored the proposal. There were no significant differences in terms of the sex, community background, or educational level of the respondents. (In addition, in a previous survey, smokers did not differ from nonsmokers on this issue.<sup>2</sup>) Young adults (aged 18 to 34 years) more strongly
? Otitic Barotrauma
Authors: A. B. Alexander
Journal: BMJ (1945)

Emery-Dreifuss Muscular Dystrophy (EDMD) is characterised by a triad of progressive myopathic changes in skeletal muscles, early contractures of the neck, elbow, ankle and cardiac conduction defects. The incidence is 1 in 100,000. Pregnancy complications include respiratory problems, cardiomyopathy, preterm delivery, low birthweight and cephalopelvic disproportion. We present a case of known EDMD who was diagnosed as a child. She booked at a height of 145cm and weighed 35kgs. Her pregnancy was a result of ovulation induction by Letrozole. A dual chamber automated implantable cardiac defibrillator inserted last year because of the high risk of sudden cardiac death associated with her condition. She has regular follow up at the breathing support clinic. Being wheel chair bound, she had reduced mobility and was commenced on thromboprophylaxis. She developed pre-ecclampsia at 26 weeks and was delivered at 28 weeks by Caesarean section under regional anaesthetic.
CALGB/SWOG 80405: Phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC).
Authors: Alan P. Venook, Donna Niedzwiecki, Heinz-Josef Lenz, Federico Innocenti, Michelle R. Mahoney, Bert H. O'Neil, James Edward Shaw, Blase N. Polite, Howard S. Hochster, James Norman Atkins, Richard M. Goldberg, Robert J. Mayer, Richard L. Schilsky, Monica M. Bertagnolli, Charles David Blanke
Journal: Journal of Clinical Oncology (2014)

LBA3 Background: Irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6), combined with bevacizumab (BV) or cetuximab (CET), are first-line treatments for metastatic adenocarcinoma of the colon or rectum (MCRC). The optimal antibody combination is unknown. Methods: Patients (pts) with KRAS wild-type (wt)(codons 12 and 13) MCRC and performance status 0-1 received FOLFIRI or mFOLFOX6 (MD/pt choice at enrollment) and randomized to either CET 400 mg/m2 X 1, then 250 mg/m2 qw or BV 5 mg/kg q2w. The original study included unselected MCRC pts receiving FOLFIRI or mFOLFOX6 and randomized to CET, BV, or both. After 1,420 pts accrued the study amended as follows: only pts with KRAS wt tumors (codon 12 and 13) were included and the combination CET + BV arm was deleted. Rx continued until progression, death, unacceptable toxicity, curative surgery; treatment holidays of 4 wks permitted. Subsequent Rx not mandated. Accrual goal was 1,142 pts. One° endpoint was overall survival (OS). Results: Between November 2005 and March 2012, 3,058 unselected pts enrolled, 2,334 KRAS wt pts randomized; final N =1137 (333 pre-amend eligible retrospective KRAS test, 804 post-amend), median f/u = 24 mos; Median age – 59 y; 61% male. Chemo/BV – 559; chemo/CET – 578. FOLFIRI = 26.6%, mFOLFOX6 = 73.4%. OS analysis planned at 849 events; efficacy futility boundary crossed at 10th interim analysis on 1/29/14. OS - chemo/BV v. chemo/CET = 29.04 (25.66 - 31.21) v. 29.93 (27.56 - 31.21) mos; HR = 0.92 (0.78, 1.09) (p value = 0.34). PFS (by investigator): chemo/BV v. chemo/CET: 10.84 (9.86 - 11.4) v. 10.45 (9.66 - 11.33) mos. There were 94 pts free of disease following surgery, median f/u 40 mos (range 8.0 - 86.0). Outcomes similar by gender. On-study toxicity and deaths as expected. Analyses underway: Expanded RAS, FOLFOX v. FOLFIRI, subsequent therapies, long-term survivors, correlates. Conclusions: Chemo/CET and chemo/BV equivalent in OS in pts KRAS wt (codons 12 + 13) MCRC; either is appropriate in first line. Overall OS of 29 + mos and 8% long-term survivors confirms progress in MCRC. The preference for FOLFOX limits chemotherapy comparison. Expanded RAS and other molecular and clinical analyses may identify subsets of pts who get more or less benefit from specific regimens. Clinical trial information: NCT00265850.