CHELATION
Authors: SAMUEL P. BESSMAN
Journal: Annals of Internal Medicine (1957)

Editorial1 November 1957CHELATIONSAMUEL P. BESSMAN, M.D., NORMAN J. DOORENBOS, Ph.D.SAMUEL P. BESSMAN, M.D., NORMAN J. DOORENBOS, Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-5-1036 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the class of compounds known as complexes, there is a group with special properties called chelates. The name chelate is derived from the Greek word for claw, an apt descriptive term for this type of substance. A chelate is a compound formed between a metallic ion and an organic molecule having two neighboring groups capable of simultaneously combining with the metal to form a ring structure. The chelate resembles a claw with the metal ion clutched between the pincers of the organic molecule.The chelate structure has such high stability that the metal ion is no longer available for...1 PetersStockenThompson RALARH: British Anti Lewisite (BAL), Nature 156: 616, 1945. CrossrefMedlineGoogle Scholar2 Bailar JC: Chemistry of the coördination compounds, 1956, Reinhold Publishing Company, New York. Google Scholar3 Grant WM: New treatment for calcific corneal opacities, A. M. A. Arch. Ophth. 48: 681, 1952. CrossrefMedlineGoogle Scholar4 HalbertsmaVan Den Brink TC: Calcinosis universalis, Maand. v. Kind. 24: 150, 1956. MedlineGoogle Scholar5 PopoviciGeschickerReinovskyRubin ACAM: Experimental control of serum calcium levels in vivo, Proc. Soc. Exper. Biol. and Med. 74: 415, 1950. CrossrefMedlineGoogle Scholar6 SpencerVankinscottLewinLaszlo HVID: Removal of calcium in man by ethylenediamine tetraacetic acid, J. Clin. Investigation 31: 1023, 1957. 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