tbuckley/cabot-search huggingface dataset:
Abstract A3: p53-dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes
Authors: Albert R. Davalos, Misako Kawahara, Gautam K. Malhotra, Jiahao Huang, Urvi Ved, Francis Rodier, Christian Beausejour, Jean Philippe Coppe, Judith Campisi
Journal: Cancer Research (2011)

Abstract Cellular senescence irreversibly arrests the proliferation of cells at risk for malignant transformation in part through activities of the transcriptional regulator and tumor suppressor p53. Cells that senesce owing to DNA damage also secrete many biologically active factors, including inflammatory cytokines such as IL-6. Some data suggest that the senescence associated secretory phenotype (SASP) creates a tumor permissive environment. However, we find that senescent cells secrete a potent bioactive molecule—High Mobility Group Box 1 (HMGB1) protein, which is unusual in having two distinct functions. Intracellularly, it binds chromatin and modulates transcription, including stimulating p53 activity. In addition, necrosis or microbial infection causes HMGB1 leakage or active secretion, respectively, whereupon it functions as an extracellular alarmin to signal tissue damage and promote tissue regeneration, stem cell recruitment and immune activation. We show that HMGB1 is largely nuclear in non-senescent human and mouse fibroblasts and epithelial cells, but is actively exported from the nucleus and secreted by senescent cells. In culture and in vivo, HMGB1 re-localization occurred prior to the appearance of other hallmarks of senescence, and depended on the function of p53, but not the upstream p53 activator ATM, which distinguished HMGB1 secretion from the SASP. Aged mice or human sera contained significantly higher levels of circulating HMGB1 compared to sera from young mice or human subjects. Disruption of HMGB1 stoichiometry, either by overexpression or depletion, induced a p53-dependent senescence growth arrest, but only HMGB1 overexpression, not HMGB1 depletion, promoted IL-6 secretion. Senescence-associated secretion required endogenous and secreted HMGB1 because deletion of endogenous HMGB1— or addition of an HMGB1 blocking antibody – attenuated IL-6 secretion. Recombinant HMGB1 protein induced IL-6 secretion in cells depleted, but not harboring, endogenous HMGB1. Depletion of endogenous HMGB1 promoted NF-κ B transcriptional activity in cells cultured with recombinant HMGB1. Our findings identify a novel biological setting (senescence), independent of necrosis or microbial infection, in which HMGB1 secretion occurs in vitro and in vivo, and link senescence-dependent HMGB1 redistribution to p53 activity and inflammatory cytokine secretion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr A3.
Infarction and coronary insufficiency during electroconvulsive therapy
Authors: V. D. Mazzia
Journal: JAMA (1968)

<h3>To the Editor:—</h3> There may be a flaw in the conclusion reached by Drs. Hussar and Pachter in their recent article on electroconvulsive therapy (<b>204</b>:1004, 1968). They report a case in which a patient with coronary artery disease suffered myocardial infarctions just following two ECT's, spaced three months apart; the second attack was a fatal one. The authors then conclude that these events were more than coincidental, and state: "We reported this case to prove that ECT may become the trigger of coronary death in persons with significant coronary heart disease." Drs. Hussar and Pachter were unable to evaluate their case in the light of a very recent report of a controlled study concerned with the drug modification of ECT.<sup>1</sup>Woodruff et al used electrocardiographic monitoring of ECT's which were either unmodified by anesthetic agents or modified by thiopental or methohexital sodium. They found that the treatment given
Doctora
Authors: Christian Meuli
Journal: JAMA (1985)

This is an insightful documentary film about "Doctora," a physician who emigrated from Germany to Bolivia in 1940 with her husband, and her work with the Aymara Indians. After five years in private practice treating the wealthy and diplomatic families of La Paz, Dr Ruth W. Tichauer became involved with the Aymara Indians after local revolutionary outbursts created many acute medical care needs. After this introduction to the Aymara people, Dr Tichauer began to devote time and energy to a poor local neighborhood organization in La Paz by coordinating a team of Aymara people to deal with a multitude of problems, including sanitation and hygiene, family issues, birth certificate verification, and the establishment of basic legal rights (land titles). As Doctora's reputation of humility, honesty, and willingness to explain basic health problems spread among the Aymara people, they began bringing sick friends and relatives from the rural interior to see
THE AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coxitis tuberkulosa: Ein Beitrag zur röntgenologischen Pathologie der Skelettuberkulose
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the New York State Medical Association for the Year 1891.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doctors' Experience in Learning from Web-Based Compared with Print-Based Materials
Journal: Annals of Internal Medicine (2000)

Summaries for Patients20 June 2000Doctors' Experience in Learning from Web-Based Compared with Print-Based MaterialsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00043 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Doctors need to keep their medical knowledge up-to-date. Recently, the number of Internet or Web-based teaching materials available to doctors has grown tremendously. Web-based materials may offer certain advantages over print materials (books, journals, guidelines), including the ability to tailor presentations to meet individual learning needs and to provide interactive teaching. It is not known, however, whether doctors actually learn better when they study Web-based rather than printed materials.Why did the researchers do this particular study?To compare how much and how quickly doctors learn using Web-based ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Self-Study from Web-Based and Printed Guideline Materials. A Randomized, Controlled Trial among Resident Physicians.” It is in the 20 June 2000 issue of Annals of Internal Medicine (volume 132, pages 938-946). The authors are D.S. Bell, G.C. Fonarow, R.D. Hays, and C.M. Mangione.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSelf-Study from Web-Based and Printed Guideline Materials Douglas S. Bell , Gregg C. Fonarow , Ron D. Hays , and Carol M. Mangione Metrics 20 June 2000Volume 132, Issue 12Page: 938KeywordsInternetMyocardial infarction ePublished: 15 August 2000 Issue Published: 20 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Positive differential heterophile antibody test. Persistence in a symptomatic patient
Authors: C. Askinazi
Journal: JAMA (1976)

A patient who had documented mononucleosis in June 1971 has been persistently symptomatic since that time, with easy fatigability and weight loss. He has also had a positive differential heterophile antibody test for mononucleosis for 14 months. Although no evidence for active Epstein-Barr virus (EBV) infection was discovered, the possibility of a chronic EBV infection is discussed. (<i>JAMA</i>236:1492-1493, 1976)
Artificial Sunlight and Its Therapeutic Uses.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A simple and inexpensive method of removal or replacement of gastrostomy tubes
Authors: J. Korula
Journal: JAMA (1991)

The safety of removal or replacement of gastrostomy tubes by simply cutting the tube and allowing the inner components to be eliminated intestinally was prospectively studied in 64 patients. In only one patient was the internal component lodged at the pylorus; it required endoscopic removal. Abdominal radiographs obtained in 57 patients confirmed complete elimination of internal percutaneous endoscopic gastrostomy components in 48 patients (84%) and identified these components in the colon in eight (14%). In two patients, the internal components were identified in the stool, and in one, radiographs were not obtained. Six patients who did not have abdominal radiographs had no problems during a mean follow-up period of 153.3 ± 37.2 days. This simple method is safe, inexpensive, can be offered to the large majority of patients with percutaneous endoscopic gastrostomy tubes, and avoids the need for endoscopic removal. (<i>JAMA</i>. 1991;265:1426-1428)
Asymptomatic cytomegalovirus infection following blood transfusion in tumor surgery
Authors: D. P. Stevens
Journal: JAMA (1970)

Forty-one patients who underwent whole blood transfusion during aggressive surgical excision of solid tumors were followed up prospectively for evidence of active cytomegalovirus (CMV) infection. Fourfold or greater elevation in complement-fixing antibody titers developed in 13 (32%) of the patients within 8 to 16 weeks after surgery. Cytomegalovirus was isolated from one of these patients. The incidence of antibody rise correlated best with volume of blood received, but it did not appear to be related to either the time of storage of transfused blood or the type of operative procedure performed. No clinical illness could be attributed to CMV infection in these patients.
Thrombocytopenia associated with long-term levodopa therapy
Authors: W. M. Wanamaker
Journal: JAMA (1976)

A 63-year-old man had severe thrombocytopenia after long-term levodopa therapy. Serologic studies and clinical features indicate that the thrombocytopenia was due to an autoimmune process, presumably similar to that induced by the chemically similar drug methyldopa. Direct allergy to levodopa was ruled out by controlled challenge of the patient receiving levodopa. Combined levodopa-prednisone therapy was then instituted, with good clinical response and no recurrence of thrombocytopenia. (<i>JAMA</i>235:2217-2218, 1976)
The Origin of Adenomatous Epithelium of the Colon
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute endotoxin tolerance downregulates superoxide anion release by the perfused liver and isolated hepatic nonparenchymal cells*1
Authors: A BAUTISTA
Journal: Hepatology (1995)

This work is based on the hypothesis that low-dose lipopolysaccharide (LPS) suppresses the stimulatory and priming effects of a subsequent high-dose endotoxin on the formation of toxic oxygen-derived radicals by the perfused liver and isolated hepatic nonparenchymal cells. Such effects may in turn contribute to hyposensitivity to the lethal effect of large doses of endotoxin. Male Sprague-Dawley rats received a nonlethal (“low-dose”) intravenous injection of Escherichia coli LPS (0.5 mg/kg body weight) 12 to 120 hours before they were challenged by a “large dose” of endotoxin (10 mg/kg). Three hours after LPS challenge, the livers were perfused, and superoxide release was determined. Nonparenchymal cells were also isolated for the determination of superoxide anion formation in vitro. There was a low rate (0.14 ± 0.1 nmol/min/g liver weight) of superoxide generated by the perfused livers from rats that received the low-dose LPS 1 to 5 days previously. Control livers generated less than 0.08 nmol superoxide. A high rate (1.3 ± 0.1 nmol/min/g) of superoxide release was measured in the perfused liver 4 hours after treatment of previously untreated control rats with large-dose LPS. This was attenuated to 0.7 ± 0.04 nmol/min/g by an injection of low-dose LPS before challenge. This attenuation was time dependent; it failed to manifest at 12, 24, or 120 hours after low-dose LPS. Isolated endothelial cells, Kupffer cells, and sequestered hepatic neutrophils from rats given a high-dose LPS also generated significant amounts of superoxide both in the presence or absence of agonists, i.e., phorbol myristate acetate or opsonized zymosan. Pretreatment of rats with the low dose of LPS 48 hours before the large dose attenuated the spontaneous and primed release of superoxide by isolated nonparenchymal cells. Serum transaminase activities were also reduced in these LPS-tolerant rats. The suppressed oxygen-derived radical formation by the liver and nonparenchymal cells during acute LPS tolerance was associated with down-regulation of tumor necrosis factor (TNF) release in vivo. TNF has been shown to stimulate and prime neutrophils and Kupffer cells for increased respiratory burst. These results suggest that suppression of free radical formation may contribute to the amelioration of hepatic injury during acute endotoxin tolerance.
Pharmacologic and Physiologic Aspects of Anesthesiology
Authors: S. H. Ngai, Lester C. Mark, E. M. Papper
Journal: New England Journal of Medicine (1970)

Physiologic EffectsNervous SystemThe general premise that anesthetics depress neuronal activity and interfere with synaptic transmission has been demonstrated with single units of excitable cells. The study of single-unit preparations provides information concerning membrane potential and excitability of the synaptic membrane. Although the organizational aspects of the central nervous system as they are affected by anesthetics cannot be determined, these studies are the first steps in attempts to understand the neural basis of anesthesia.Chalazonitis165 showed in the visceral ganglion of aplysia and nerve cells of helix that anesthetics, including halothane, chloroform and diethyl ether, hyperpolarize the synaptic membrane. . . .
Medical Disorders of the Locomotor System Including the Rheumatic Diseases
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive models for hepatocellular carcinoma (HCC) occurrence in patients with chronic hepatitis C and sustained virological response (SVR) achieved with direct acting anti-viral (DAA) included in the ANRS CO22 hepather cohort
Authors: Nathalie Ganne-Carrié, Azzi Jessica, Dorival Celine, Carole Cagnot, Helene Fontaine, Clovis Lusivka-Nzinga, Stanislas Pol, Fabrice Carrat
Journal: Journal of Hepatology (2020)
MULTIPLE MYELOMA
Authors: OLGA S. HANSEN
Journal: JAMA (1922)

Since 1847, when Bence-Jones<sup>1</sup>first described a substance occurring in the urine of a patient said to have "mollities ossium," there has been much study and thought put on this rare disease, which was first named multiple myeloma by Rustizky,<sup>2</sup>in 1873. It must be confessed that but little more is known of the cause and treatment of the disease or of the origin of the curious Bence-Jones body, which is so frequently found on urinalysis, than when it was first described. Kahler, in 1889, reported a case of eight years' duration. The disease is often called by his name. Multiple myeloma has been defined by Ewing<sup>3</sup>as a "specific malignant tumor of the bone marrow, arising probably from a single cell type. It is characterized by multiple foci of origin, a uniform and specific structure composed of plasma cells or their derivatives, rare metastases, albumosuria and
June 21, 2000
Journal: JAMA (2000)

Andres M. Salazar, MD; Deborah L. Warden, MD; Karen Schwab, PhD; Jack Spector, PhD; Steven Braverman, MD; Joan Walter, PA; Reginald Cole, MD; Mary M. Rosner, MA; Elisabeth M. Martin, RN; James Ecklund, MD; Richard G. Ellenbogen, MD; for the Defense and Veterans Head Injury Program (DVHIP) Study Group
Undergraduate teaching in paediatrics.
Journal: BMJ (1967)

of Ibadan, Nigeria, outlines some problems presented to the pathologist (p.715).Test for Insulin Antibodies: Dr. T. A. Welborn and colleagues describe simple method to assess titre of antibodies in serum (p.719).Osteomyelitis: Dr. L. R. I. Baker and col- leagues report three cases complicating failure of normal neutrophil response to infection (p. 722).Circulation and the Pill: Drs