tbuckley/cabot-search huggingface dataset:
New Approaches for Estimating Risk from Exposure to Diethylstilbestrol
Authors: Gerald R. Cunha, John-Gunnar Forsberg, Robert Golden, Arthur Haney, Taisen Iguchi, Retha Newbold, Shanna Swan, Wade Welshons
Journal: Environmental Health Perspectives (1999)

A subgroup from a National Institute of Environmental Health Sciences, workshop concerned with characterizing the effects of endocrine disruptors on human health at environmental exposure levels considered the question, If diethylstilbestrol (DES) were introduced into the market for human use today and likely to result in low-dose exposure of the human fetus, what would be required to assess risk?On the basis of an analysis of the quality of data on human DES exposure, the critical times and doses for inducing genital tract malformations and cancer must be determined.This would be facilitated through analysis of the ontogeny of estrogen receptor expression in the developing human genital tract.Models of low-dose estrogenic effects will have to be developed for human and rodent genital tract development.Mouse models offer many advantages over other potential animal models because of the wealth of the earlier literature, the availability of sensitive end points, the availability of mutant lines, and the possibility of generating genetically engineered model systems.Through multidisciplinary approaches, it should be possible to elucidate the cellular and molecular mechanisms of endocrine disruption elicited by estrogens during development and facilitate an assessment of risk to humans.
USE OF SILVER NITRATE OINTMENT IN THE TREATMENT OF VULVOVAGINITIS IN CHILDREN
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of the clinical management of cancer patients. A pilot study
Authors: R. E. Lenhard
Journal: JAMA (1983)

The Johns Hopkins Oncology Center, Baltimore, has carried out a pilot study of a method of data collection and analysis to be used for planning and evaluation of continuing education programs conducted in the Maryland region. This study includes definition of techniques used to prepare a test instrument that will accurately reflect actual medical practice within a hospital. The system has been field tested in three diseases, cancer of the lung, breast, and uterine cervix, in two Maryland hospitals. The system appears to be an efficient and inexpensive method for definition of decision making in specific clinical settings and for measurement of change if serial reassessment is instituted. (<i>JAMA</i>1983;250:3310-3316)
New Vaccine Decreases Rate of Nosocomial Infections
Authors: B. Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Should radiologists talk to patients?
Journal: BMJ (1990)

the 12 000 dives surveved by us included episodes of rapid or uncontrolled ascent.For what it is worth, we have anecdotal reports of six divTing incidents relating to asthmatic divers-four in which there were rapid ascents and two in which divers developed bronchospasm underwater.In all of these cases the divers concerned surfaced safely.As medical examiners who dive we make it our business to discuss with our clients the examination, the implications of any abnormal findings, and any possible theoretical risks.We believe that this approach is adequate for medicolegal purposes.It would seem reasonable to advise people with well controlled asthma who wish to dive that they mav do so as long as they understand the theoretical risks.The real risk, if in practice there is one, would seem slight according to currently available data.Therefore the British Sub-Aqua Club's current recommendations seem adequate.
SURGICAL CORRECTION OF MALFORMATION AND SPEECH DEFECTS DUE TO OR ASSOCIATED WITH HARE-LIP AND CLEFT PALATE.
Authors: GEORGE V. I. BROWN
Journal: JAMA (1902)

The purpose of this discussion is to make clear advantageous possibilities in the treatment of hare-lip and cleft palate by a new method which, 1, reduces the width of the fissure and thus renders a subsequent operation for closure by operation upon the soft tissues more certainly successful and more beneficial by preserving the usefulness of the soft parts; 2, by readjustment of the unequally developed bone structures, gives a more perfect contour to the form of the face after operation; 3, makes it possible to operate successfully upon patients almost with regard to age limitations. The objects which make relief of some kind desirable if not imperative for patients so afflicted, whether the method of procedure be surgical or prosthetic, may be summed up in the two considerations, health and speech, for the purpose, of all treatment must be directed toward improvement in one or both of these requisites.
PROPOSED LEGISLATION IN REGARD TO EXPERT TESTIMONY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pure red cell aplasia associated with sodium valproate therapy
Authors: L. G. MacDougall
Journal: JAMA (1982)

Pure red cell aplasia developed in a 9-year-old girl receiving sodium valproate therapy. Infection with measles and chickenpox had occurred two months previously. Regeneration of bone marrow erythroid precursors was demonstrated one month after drug withdrawal. Readministration of sodium valproate resulted in a second episode of red cell aplasia that again resolved promptly after drug withdrawal. The respective roles of infection and drugs in the etiology of red cell aplasia are discussed. (<i>JAMA</i>1982;247:53-54)
Moves On
Authors: George N. Braman
Journal: Annals of Internal Medicine (2006)

Ad Libitum15 August 2006Moves OnGeorge N. Braman, MDGeorge N. Braman, MDFrom Bronx, NY 10471.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-4-200608150-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “Things fall apart; the centre cannot hold;Mere anarchy is loosed upon the world … ”—William Butler Yeats, “The Second Coming”... Author, Article, and Disclosure InformationAffiliations: From Bronx, NY 10471.Current Author Addresses: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 2006Volume 145, Issue 4Page: 301KeywordsFallsHeart rate ePublished: 15 August 2006 Issue Published: 15 August 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
`Brain Death' and Organ Retrieval
Authors: Stuart J. Youngner
Journal: JAMA (1989)

A sample of 195 physicians and nurses likely to be involved in organ procurement for transplantation was interviewed about knowledge, personal concepts, and attitudes concerning "brain death" and organ donation. Only 68 respondents (35%) correctly identified the legal and medical criteria for determining death. Personal concepts of death varied widely. Most respondents (58%) did not use a coherent concept of death consistently; others (19%) had a concept of death that was logically consistent with changing the whole-brain standard to classify anencephalics and patients in a persistent vegetative state as dead. The findings demonstrate confusion about correct criteria for determining death and differences in concepts of death that might prove troublesome to the transplantation enterprise. We conclude that health professionals should do more to resolve the clinical and conceptual issues in the definition and determination of death before policies concerning organ retrieval are changed. (<i>JAMA</i>. 1989;261:2205-2210)
LENINGRAD
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospitals, Chicago
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minerva
Journal: BMJ (2002)

26 pilgrims carrying the W135 clone (all from different households), six (23%) transmitted this strain to seven contacts, of whom two were from the same household.The acquisition rate of the W135 clone in contacts of returning carriers of the same strain was 13% (seven out of 54 contacts). CommentsA high acquisition rate of a single clone of W135 N meningitidis occurred during the 2001 Hajj pilgrimage.Many countries currently give bivalent meningococcal vaccine (covering A and C) to Hajj pilgrims.Vaccination with the quadrivalent meningococcal vaccine (also covering W135) should become mandatory for all Hajj pilgrims and be considered for their household contacts.Transmission of this clone from vaccinated Hajj returnees to their unvaccinated household contacts was substantial, putting contacts at particular risk of developing invasive disease.Our findings support a policy of administering antibiotics to pilgrims before their return to their countries of origin to eradicate carriage and thereby protect household contacts.We thank Fatimah Karim and Anushia Panchalingham for taking swabs, Bernard Peperstraete for logistical help, Sindhu Ravindran for performing pulsed field gel electrophoresis, and Gamini Kumarsinghe for providing some of the meningococcal isolates of clinical cases.We also thank all the pilgrims and their contacts for participating in this study.Contributors: AW-S had the idea for the study and was responsible for study design and for collection, analysis, and interpretation of data.TMSB was responsible for the meningococcal cultures, serogrouping, and pulsed field gel electrophoresis.AE was responsible for data entry and analysis.
HIGH DOSE IRRADIATION INJURY
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurogenic Bladder
Authors: Bernard R. Sears
Journal: JAMA (1967)

All credit to Doctor Boyarsky for his symposium! A progress report for "the advanced worker," it is the most important book on the subject since George Prather's monograph, in 1949, established formal recognition of this special field. Prather collated the literature with his extensive war experience and provided a detailed manual for treatment based on physiologic principles. Clinical reports and evaluations then proliferated; on the scientific side, research techniques increased. Dr. Boyarsky and his panelists are among those who have accounted for our great depot of data and ideas. Here, in papers and discussions, they present personal work, assess methods and findings, and chart areas for future study. So wide is the scope of material that the book must have value for everyone directly or indirectly interested. The reader gains a full purview of the field and of the different explorations relevant to its advance. The clinician sees lines of
Perspectives on the Risk Assessment for Nongenotoxic Carcinogens and Tumor Promoters
Authors: Frederica P. Perera
Journal: Environmental Health Perspectives (1991)

The issue of risk assessment for carcinogens that appear to act via nongenotoxic mechanisms or at the tumor promo- tion stage, respectively, is discussed in light ofcurrent information on biological mechanisms involved in carcinogenesis as well as interindividual variability in human response.Proposals to treat "nongenotoxic" carcinogens and tumor pro- moters as posing lower risks to humans are described and evaluated.It is concluded that, for purposes of risk assessment and regulation, there is currently no convincing scientific rationale for constructing categories ofcarcinogens according to their presumed mechanism or stage of action.
Neurotoxicity Testing: A Discussion of in Vitro Alternatives
Authors: Lucio G. Costa
Journal: Environmental Health Perspectives (1998)

A large number of chemicals may exert adverse effects on the central and/or peripheral nervous system.A commonly recommended strategy for neurotoxicity testing is that of a tiered approach aimed at identifying and characterizing the neurotoxicity of a compound.Guidelines exist in the United States and other countries that define the tests to be utilized in tier 1 testing.To address problems related to the increasing cost and time required for toxicity testing, the increasing number of chemicals being developed, and the concern of animal welfare activists, attention is currently being devoted to in vitro alternatives.This paper addresses the use of in vitro systems in neurotoxicology, and their potential role in a general strategy for neurotoxicity testing.The advantages and disadvantages of in vitro approaches for mechanistic studies and for screening of neurotoxicants are discussed.Suggestions for further validation studies are proposed.
Saint Thomas' Hospital Reports.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial distribution of 99mTcN-NOET following occlusion and reperfusion with residual ischemia and necrosis Zhonglin Liu, Gerald Johnson, III, Curtis L. Hart, Michael W. Eaton, Roberto Pasqualini, Robert D. Okada. University of Oklahoma, Tulsa, OK, Schering-Cis bio international, Gifsur-Yvette, France
Journal: Journal of the American College of Cardiology (2001)
Environmental and Biological Monitoring of Benzene during Self-Service Automobile Refueling
Authors: Peter P. Egeghy, Rogelio Tornero-Velez, Stephen M. Rappaport
Journal: Environmental Health Perspectives (2000)

Although automobile refueling represents the major source of benzene exposure among the nonsmoking public, few data are available regarding such exposures and the associated uptake of benzene. We repeatedly measured benzene exposure and uptake (via benzene in exhaled breath) among 39 self-service customers using self-administered monitoring, a technique rarely used to obtain measurements from the general public (130 sets of measurements were obtained). Benzene exposures averaged 2.9 mg/m(3) (SD = 5.8 mg/m(3); median duration = 3 min) with a range of < 0.076-36 mg/m(3), and postexposure breath levels averaged 160 microg/m(3) (SD = 260 microg/m(3)) with a range of < 3.2-1,400 microg/m(3). Log-transformed exposures and breath levels were significantly correlated (r = 0.77, p < 0.0001). We used mixed-effects statistical models to gauge the relative influences of environmental and subject-specific factors on benzene exposure and breath levels and to investigate the importance of various covariates obtained by questionnaire. Model fitting yielded three significant predictors of benzene exposure, namely, fuel octane grade (p = 0.0011), duration of exposure (p = 0.0054), and season of the year (p = 0.032). Likewise, another model yielded three significant predictors of benzene concentration in breath, specifically, benzene exposure (p = 0.0001), preexposure breath concentration (p = 0.0008), and duration of exposure (p = 0.038). Variability in benzene concentrations was remarkable, with 95% of the estimated values falling within a 274-fold range, and was comprised entirely of the within-person component of variance (representing exposures of the same subject at different times of refueling). The corresponding range for benzene concentrations in breath was 41-fold and was comprised primarily of the within-person variance component (74% of the total variance). Our results indicate that environmental rather than interindividual differences are primarily responsible for benzene exposure and uptake during automobile refueling. The study also demonstrates that self-administered monitoring can be efficiently used to measure environmental exposures and biomarkers among the general public.
National Standards for Diabetes Self-Management Education
Authors: Carolé Mensing, Jackie Boucher, Marjorie Cypress, Katie Weinger, Kathryn Mulcahy, Patricia Barta, Gwen Hosey, Wendy Kopher, Andrea Lasichak, Betty Lamb, Mavourneen Mangan, Jan Norman, Jon Tanja, Linda Yauk, Kimberlydawn Wisdom, Cynthia Adams
Journal: Diabetes Care (2002)