tbuckley/cabot-search huggingface dataset:
Serum hepatocyte growth factor levels in liver diseases: Clinical implications
Authors: G SHIOTA
Journal: Hepatology (1995)

Although recent studies have shown that hepatocyte growth factor (HGF) is a potent mitogen in vivo, the significance of serum HGF in liver diseases remains unclear. To clarify clinical significance of serum HGF in liver diseases, serum HGF was measured in 127 patients with liver diseases and in 200 healthy individuals, using a highly sensitive immunoradiometric assay (IRMA). This assay is specific for HGF and is sensitive enough to detect 0.1 ng/mL of HGF. Mean values for serum HGF in acute hepatitis (AH), chronic hepatitis (CH), liver cirrhosis (LC), hepatocellular carcinoma (HCC), primary biliary cirrhosis (PBC), fulminant hepatic failure (FHF), and normal controls were 0.45, 0.40, 1.05, 1.06, 0.44, 16.40, and 0.27 ng/mL, respectively. Serum HGF levels in these diseases were significantly increased compared with those in the controls (P<.001), and exhibited a positive correlation with total bilirubin, indocyanine green (ICG) test (R15), asparate aminotransferase (AST), and a negative correlation with albumin and prothrombin time (P<.001). Cirrhotic patients with modified Child class C had higher levels of serum HGF than those graded as modified Child class A or B (P<.001). In CH, serum HGF levels were significantly related to the histological activity index (HAI) score (P<.002). Seven patients with HCC who underwent transcatheter arterial embolization (TAE0 exhibited a gradual increase in serum HGF levels up to day 4 after treatment; these higher levels were maintained until day 7, although AST reached a peak on day 2 and then decreased gradually. During clinical courses of patients with AH and CH, serum HGF was increased immediately after elevations of aminotransferases, and decreased as clinical symptoms improved. Serum HGF levels in survivors with FHF or AH were decreased during the illness (P = 0.0156), whereas serum HGF levels in nonsurvivors with FHF were increased. These findings suggest that serum HGF reflects the degree of liver dysfunction in chronic hepatic failure, and that serial measurement of serum HGF levels in acute hepatic injury serves as a prognostic factor. (Hepatology 1995;21:106–112).
Aleya Banerjee
Authors: A. Banerjee, A. Banerjee, A. Banerjee
Journal: BMJ (2010)

<h3>Abstract</h3> Since the COVID-19 pandemic started, the public has been eager for news about promising treatments, and social media has played a large role in information dissemination. In this paper, our objectives are to characterize the public discussion of treatments on Twitter, and demonstrate the utility of these discussions for public health surveillance. We pulled tweets related to three promising COVID-19 treatments (hydroxychloroquine, remdevisir and convalescent plasma), between the dates of February 28th and May 22nd using the Twitter public API. We characterize treatment tweet trends over this time period. Most major tweet/retweet/sentiment trends correlated to public announcement made by the white house and/or to new clinical trial evidence about treatments. Most of the websites people shared in treatment-related tweets were non-scientific media sources that leaned conservative. Hydroxychloroquine was the most discussed treatment on Twitter, and over 10% of hydroxychloroquine tweets mentioned an adverse drug reaction. There is a gap between the public attention/discussion around COVID-19 treatments and their evidence. Twitter data can and should be used public health surveillance during this pandemic, as it is informative for monitoring adverse drug reactions, especially as many people avoid going to hospitals/doctors.
The Orthopantomogram
Authors: Arthur B. King
Journal: JAMA (1980)

<h3>To the Editor.—</h3> From the letter entitled "The Orthopantomogram" (243: 1131, 1980), it would appear that physicians are rapidly losing their clinical touch and acumen. In 40 years of doing neurosurgery, I have never seen tic douloureux in a patient aged 14 years, so a patient appearing with the complaint of facial pain should make tic douloureux the most unlikely diagnosis. On the other hand, dental problems are exceedingly common in this age group. I have seen several such cases, and a simple examination of just tapping the teeth with a jackknife or a pair of scissors will make the diagnosis instantly if one taps the affected tooth, even though it appears normal. In the several cases I had, I did not have to resort to use of a computerized tomographic scan, EEG, posterior fossa angiogram, carbamazepine (Tegretol), or other such diagnostic procedures. In fact, I had to find out
The Combination of Quizartinib with Azacitidine or Low Dose Cytarabine Is Highly Active in Patients (Pts) with FLT3-ITD Mutated Myeloid Leukemias: Interim Report of a Phase I/II Trial
Authors: Gautam Borthakur, Hagop M. Kantarjian, Susan O'Brien, Guillermo Garcia-Manero, Elias Jabbour, Naval Daver, Tapan M. Kadia, Rosilyn Gborogen, Marina Konopleva, Michael Andreeff, Farhad Ravandi, Jorge E. Cortes
Journal: Blood (2014)
THE COMPASSIONATE EDITOR
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TREATMENT OF CARBON MONOXID POISONING
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Doctors and driving licences.
Journal: BMJ (1976)

prompted by K Modigh's experiments showing that 5-HT functional activity is increased in mice given chlorimipramine plus L-tryptophan.18The conference brought together biochemists, pharma- cologists, and psychiatrists to discuss the place of L-tryptophan in clinical practice; but (as was pointed out by Sir Martin Roth in his summing up) more clinical studies on the use of L-tryptophan in depression are needed before a conclusion can be reached on its role, especially when combined with other antidepressant drugs.Furthermore, this meeting dealt only with the role of 5-HT in depression; probably other neurotransmitters may also be concerned.
Pyopericardium
Authors: O. S. Tubbs
Journal: BMJ (1948)

imperfect senses are incapable of accurately reflecting objective reality, so we are excluded from the possibility of any real knowledge.For such a philosophical standpoint carried to its logical con- clusion, truth and untruth, objective fact and illusion, scientific knowledge and primitive superstition, are all equally valid, and the scientist accepting these views is automatically led to empiricism and pragmatism.With Dewey, he is forced to believe that knowledge is an instrument which depends on our interests and advantages, and he eventually develops a completely cynical approach to his subject.It is especialy the great complexity, the enornmous number of mutually interconnected processes in living matter, together with the comparative lack of success of medical investigation when superficially compared with the so-called exact sciences-physics, chemnistry, and mathematics-which make the medical worker particularly liable to adopt such an attitude.Thus there has arisen in biology on the one hand a neo- vitalism which claims that the living organism is " unknowable " and that all we can do is lead a despairing " hanid-to-mouth "
EPIDEMIOLOGY OF PARATYPHOID FEVER.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>The Ætiology of Osseous Deformities of Head, Face, Jaws, and Teeth.</i>By Eugene S. Talbot, M. D., D. D. S., Professor of Dental Surgery, Womans' Medical College, Chicago, Ill. Third Edition, Revised and Enlarged. Chicago: The W. T. Keener Company, 1894
Journal: American Journal of Psychiatry (1894)
Survey of sickle-cell disease in England and Wales.
Journal: BMJ (1982)

The incidence and the clinical course of patients suffering from sickle-cell syndrome (Hb SS; Hb SC; Hb S thal) in England and Wales are not known.In 1979 an ad hoc committee was formed to investigate these problems.Initially, a questionnaire was sent to 227 haematologists in England and Wales to determine the number of cases in these countries.The replies have indicated that 1367 cases were seen in 1978 and 1979.Probably this may represent only half the total number of cases.From this survey it has been possible to draw up a composite map showing the location of patients, which has provided a basis to determine the clinical course of the disease, and for further studies into the complications and management of sickle-cell disease in England and Wales.From a second questionnaire preliminary data about the general management and mortality in England and WVales have been recorded.
Syndromes of Q fever
Authors: J. Eshchar
Journal: JAMA (1966)

SINCE THE original description of Q fever, it has been established that<i>Coxiella burnetii</i>has a worldwide distribution. The abundance of reports on epidemic and sporadic cases of Q fever, displaying a protean and often uncharacteristic symptomatology, encouraged us to undertake a systematic study of this disease entity and its part in the causation of various clinical syndromes, such as infectious hepatitis,<sup>1</sup>fever of uncertain origin, and infectious mononucleosis. It is the purpose of this communication to present seven cases of Q fever, five of which were originally labelled "fever of uncertain origin," and two of which displayed a clinical picture suggesting infectious mononucleosis. <h3>Materials and Methods</h3> A group of 119 patients classified as having "fever of uncertain origin" and a group of 13 with the clinical diagnosis of infectious mononucleosis were studied for Q fever. The microscopic-slide agglutination test, introduced by Babudieri<sup>2</sup>was employed in all cases
Physiological Thyroid Hormone Levels Regulate Numerous Skeletal Muscle Transcripts
Authors: W. Edward Visser, Karen A. Heemstra, Sigrid M. A. Swagemakers, Zeliha Özgür, Eleonora P. Corssmit, Jacobus Burggraaf, Wilfred F. J. van Ijcken, Peter J. van der Spek, Johannes W. A. Smit, Theo J. Visser
Journal: Endocrine Reviews (2009)

ABSTRACT Context Skeletal muscle is an important target tissue for thyroid hormone (TH). It is currently unknown which genes are regulated by physiological TH levels. Objective We examined the effects of l-thyroxine on human skeletal muscle transcriptome. Design Microarray analysis of transcript levels was performed using skeletal muscle biopsies from patients under euthyroid and hypothyroid conditions. Setting The study was conducted in a university hospital laboratory. Patients We studied skeletal muscle obtained from 10 thyroidectomized patients with differentiated thyroid carcinoma on and after 4 wk off l-thyroxine replacement. Mean Outcome Measures Gene expression changes were measured using microarrays. Results were analyzed using dedicated statistical methods. Results We detected 607 differentially expressed genes on l-thyroxine treatment, of which approximately 60% were positively and approximately 40% were negatively regulated. Representative genes were validated by quantitative PCR. Genes involved in energy and fuel metabolism were overrepresented among the up-regulated genes, of which a large number were newly associated with thyroid state. l-thyroxine therapy induced a large down-regulation of the primary transcripts of the noncoding microRNA pair miR-206/miR-133b. Conclusion We demonstrated that physiological levels of TH regulate a myriad of genes in human skeletal muscle. The identification of novel putatively TH-responsive genes may provide the molecular basis of clinical effects in subjects with different TH status. The observation that TH regulates microRNAs reveals a new layer of complexity by which TH influences cellular processes.
Mythical Monsters
Authors: Samuel Vaisrub
Journal: JAMA (1977)

In his essay on biomythology, Lewis Thomas<sup>1</sup>infuses a new meaning into mythical creatures that abound in primitive lore. The ganesha possessing a human body and the head of an elephant; the sphinx with the head of a woman and the body of a lion; the manticore with a lion's body, a man's face, and a snake's head; and many other creatures of myth—all share one attribute in common. They are consortia, fusions of man, beast, bird, or fish. To Thomas, this hybrid quality symbolizes nature's symbiotic combinations, unexpected unions of diverse species—a countertrend to speciation. As a prime example of such a union, he cites the ingress of oxygen-utilizing bacteria a billion or so years ago into the larger nucleated animal cells to become incorporated as mitochondria. Any cell—man, animal, fish, fowl, or insect—given the chance and under the right conditions, brought into contact with any other cell,
The Commonwealth Fund Thirtieth Annual Report for the Year Ending September 30, 1948
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Lymphomas: Current Concepts in Pathogenesis and Management
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article The Lymphomas: Current Concepts in Pathogenesis and Management Get access JNCI: Journal of the National Cancer Institute, Volume 82, Issue 11, 6 June 1990, Page 981, https://doi.org/10.1093/jnci/82.11.981 Published: 06 June 1990
Parents With Cancer
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In-press articles
Authors: Mu ¨beccel Akdis, Kurt Blaser, Cezmi Akdis, Kimberly Mascia, Tmirah Haselkorn, Yamo Deniz, Dave Miller, Eugene Bleecker, Larry Borish, Sarah Appleton, Robert Adams, David Wilson, Anne Taylor, Richard Ruffin, Celine Bergeron, Hans Hauber, Mark Gotfried, Kenneth Newman, Rahul Dhanda, Ronald Servi, Mara Ludwig, Qutayba Hamid
Journal: Journal of Allergy and Clinical Immunology (2005)
Myelodysplastic syndromes with nephrotic syndrome
Authors: Takayuki Saitoh, Hirokazu Murakami, Hideki Uchiumi, Kazuaki Moridaira, Tadashi Maehara, Takafumi Matsushima, Norifumi Tsukamoto, Jun'ichi Tamura, Masamitsu Karasawa, Takuji Naruse, Jun Tsuchiya
Journal: American Journal of Hematology (1999)

It is sometimes reported that the immunological abnormalities in myelodysplastic syndromes (MDS) induce autoimmune disease (i.e., acute systemic vasculitic syndrome, chronic cutaneous vasculitis, polyneuropathy, relapsing polychondritis, and steroidresponsive pulmonary disorders).We investigated the clinical features of patients with MDS accompanied by nephrotic syndrome.We enrolled 125 patients with MDS who were admitted between January 1979 and May 1996 in this study.The renal function was assessed based on the laboratory data and the findings at the physical examination.The diagnoses of nephrotic syndrome and glomerular disease were established when 24-hr urinary excretion was more than 3.5 g and serum total protein was less than 6.0 g/dl, and when the 24-hr protein excretion was more than 1.5 g.Five patients (4%) had glomerular disease, and three (2.4%) had nephrotic syndrome.Of the five patients with glomerular disease, two had refractory anemia (RA), and three had chronic myelomonocytic leukemia (CMMOL).Three of the total 11 patients with CMMOL were diagnosed as having nephrotic syndrome.Among the CMMOL patients, those with nephrotic syndrome showed higher absolute monocyte numbers than did those without nephrotic syndrome (8830 ± 4677/µl vs. 3061 ± 2887/µl, P = 0.03).One CMMOL patient was treated with VP-16 and hydroxyurea.As the white blood cell count in this patient decreased, the 24-hr urine protein excretion and the serum tumor necrosis factor alpha level decreased.The relationship between nephrotic syndrome and CMMOL was not clear.High monocyte count and the serum cytokines in MDS patients may play a partial role in the evolution of glomerulonephritis, and CMMOL may be closely related to nephrotic syndrome.Am.
Abstract 17798: Statin Persistence After Reported Adverse Reactions and Patient Outcomes
Authors: Huabing Zhang, Jorge Plutzky, Maria Shubina, Alexander Turchin
Journal: Circulation (2015)

Evidence suggests that many patients tolerate statin therapy after an adverse reaction. However, clinical outcomes of statin persistence after adverse reactions are unknown. We conducted a retrospective cohort analysis of the relationship between persistent statin therapy during 12 months after an adverse reaction, and cardiovascular (CV) events (myocardial infarctions and strokes) and death from any cause. We studied patients in primary care practices at two academic medical centers who reported an adverse reaction to a statin between 2000 and 2011 and were subsequently followed for at least 12 months. Adverse reactions to statins were identified using a combination of natural language processing of provider notes and EMR data. Among 28,279 study patients, 19,997 (70.7%) had persistent statin therapy after an adverse reaction. There were 10,203 (36.1%) patients at high CV risk (previous history of coronary artery disease (CAD), stroke or diabetes). Over a mean of 1,333 days of follow-up, 2,390 (8.45%) of patients suffered a CV event and 1,354 (4.8%) patients died. In univariate analysis, among patients at high CV risk 25.7% of patients who stopped statins reached composite primary outcome (CV event or death) vs. 19.6% of patients who had persistent statin therapy (Figure; p &lt; 0.0001). In multivariable analysis adjusted for demographics, smoking status, Charlson Comorbidity Index, family history of stroke or CAD, blood pressure, body mass index, LDL cholesterol level, and renal function, persistent statin therapy was associated with a hazard ratio for primary outcome of 0.887 (95% CI 0.807 - 0.976; p=0.014). Persistent statin therapy was not associated with increased time to primary outcome in either univariate or multivariable analysis among patients with low baseline CV risk. Persistent statin therapy after a reported adverse reaction to a statin was associated with longer time to CV event or death in patients at high but not low CV risk.