tbuckley/cabot-search huggingface dataset:
Tachyarrhythmias in Wolff-Parkinson-White syndrome. Antiarrhythmic drug therapy
Authors: E. K. Chung
Journal: JAMA (1977)

EVERY physician should be fully familiar with the Wolff-Parkinson-White (WPW) syndrome because it is frequently associated with the various ectopic tachyarrhythmias. In addition, the electrocardiographic findings in the WPW syndrome may closely resemble many other abnormalities that are frequently misinterpreted in our daily practice. The WPW syndrome was first recognized as a clinical entity by Wolff et al,<sup>1</sup>in 1930. The ECG findings, which were later considered to be characteristic of this syndrome, were described by Wilson<sup>2</sup>in 1915, and by Wedd<sup>3</sup>in 1921. The tachyarrhythmias may occur at any time and may begin at birth or during infancy, childhood, or adult life. Sixty percent to 70% of the cases with WPW syndrome have been encountered in healthy individuals without organic heart disease.<sup>4</sup> Wolff-Parkinson-White syndrome can be diagnosed by the surface 12-lead electrocardiogram, the His bundle electrogram, or vectorcardiogram. The typical ECG findings include a short
Butcher-Shop Regulation.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gonorrhea detection in posthysterectomy patients
Authors: B. D. Klaus
Journal: JAMA (1978)

A retrospective study of women examined at the Venereal Disease Clinic after hysterectomy was made to determine which culture site was most likely to show anogenital<i>Neisseria gonorrhoeae</i>infection when the cervix was absent. Seventeen of 104 such patients were culture positive for<i>N gonorrhoeae</i>. Rates of positivity for our culture sites were as follows: urethral, 17/17 (100%); vaginal, 7/17 (41%); and rectal, 2/17 (12%). (<i>JAMA</i>240:1360-1361, 1978)
Diagnosing dementia: do we get it right?
Journal: BMJ (1988)

To find out whether the diagnosis of dementia agreed with findings at necropsy a detailed assess- ment of 27 elderly patients (mean age 82 (range 70-94)) presenting with dementia was conducted at a combined department of geriatric medicine and psychiatry for the elderly.On the basis of the results the cause of the dementia was diagnosed clinically.Neuropathological examinations were performed after death.The clinical diagnosis made during life was not supported by the findings at necropsy in 11 cases.Alzheimer's disease was overdiagnosed in life (13 cases, of which only six were confirmed at necropsy).Although the clinical investigation was limited by availability of resources, neither cranial computed tomography nor the Hachinski score helped to distinguish between multi-infarct dementia and Alzheimer's disease in this age group.This study confirms the value of neuropathological studies in the precise diagnosis of dementia.TABLE I -Scheme for calculating Hachinski ischaemic score Characteristic Score Abrupt onset 2 Stepwise deterioration 1 Fluctuating course
False-Positive Rate of Posttherapy Positron Emission Tomography in Cervical Cancer—Reply
Authors: Julie K. Schwarz
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Figure Labels Transposed in: Efficacy and Safety of a 4-Drug Fixed-Dose Combination Regimen Compared With Separate Drugs for Treatment of Pulmonary Tuberculosis: The Study C Randomized Controlled Trial
Journal: JAMA (2011)

Efficacy and Safety of a 4-Drug Fixed-Dose Combination Regimen Compared With Separate Drugs for Treatment of Pulmonary Tuberculosis
Correction: Flow cytometric detection of leukemic blasts in cerebrospinal fluid predicts risk of relapse in childhood acute lymphoblastic leukemia: a Nordic Society of Pediatric Hematology and Oncology study
Authors: Maria Thastrup, Hanne Vibeke Marquart, Mette Levinsen, Kathrine Grell, Jonas Abrahamsson, Birgitte Klug Albertsen, Thomas Leth Frandsen, Arja Harila-Saari, Päivi Maria Lähteenmäki, Riitta Niinimäki, Cornelis Jan Pronk, Aina Ulvmoen, Goda Vaitkevičienė, Mervi Taskinen, Kjeld Schmiegelow, Peder Wehner, Britt-Marie Frost, Ulrika Norén-Nyström, Mikael Behrendtz, Bendik Lund, Jouni Pesola, Dorota Malgorzata Wojcik
Journal: Leukemia (2020)
A multicenter phase I study of cabazitaxel (Cbz), mitoxantrone (Mito), and prednisone (Pred) (CAMP) for chemotherapy-naïve patients with metastatic castration-resistant prostate cancer (mCRPC).
Authors: Rahul Raj Aggarwal, Alan H. Bryce, Vivian K. Weinberg, Charles J. Ryan, Christina Louise Derleth, Andrea Harzstark, Mina Lee, Eric Jay Small
Journal: Journal of Clinical Oncology (2015)

238 Background: Cbz/pred extends survival in mCRPC patients (pts) following docetaxel and first-line studies comparing Cbz to docetaxel are ongoing. Mito/pred also has anti-tumor activity in mCRPC and a non-overlapping mechanism of action and toxicity profile with Cbz. A multicenter phase 1 trial was initiated through the DOD PCCTC to establish the maximally tolerated dose (MTD) and recommended phase 2 dose (RP2D) of the combination of Cbz, Mito, and Pred (CAMP). Methods: Chemotherapy (chemo)-naïve pts with mCRPC were enrolled in an accelerated titration design. The primary objective was to determine the MTD and RP2D of CAMP; secondary objectives included PSA response rate and duration of response. Cbz 20 and 25 mg/m 2 were each evaluated in combination with escalating doses of Mito (starting dose 4 mg/m 2 ), both administered on day 1 of a 21-day cycle. Pred 5 mg BID and pegfilgrastim were given with each cycle. Results: 20 pts were enrolled. The median age was 66 (range 51-78) and the median baseline PSA was 62.5 (range 3.0-791.2). There were 2 DLTs observed at the dose level of Cbz 25 mg/m 2 + Mito 10 mg/m 2 (sepsis and febrile neutropenia). No DLTs were observed with Cbz 20 mg/m 2 (N = 10), establishing Cbz 20 mg/m 2 + Mito 12 mg/m 2 as the MTD and RP2D. The most common grade ≥ 3 related adverse events were hematologic (neutropenia, n = 8; thrombocytopenia, n = 3; febrile neutropenia, n = 2). No cardiac adverse events were observed. The median number of treatment cycles was 9 (range 2-16), and 5 pts remain on study. Greater than 50% maximal PSA declines from baseline were observed in 8 of 18 evaluable pts (44%). Objective tumor responses have been observed in 2 of 4 pts (50%) with measurable disease, with evaluation ongoing. The median duration of response has not been reached (range 4.9-10.0+ months). Conclusions: The approved single-agent dose of Mito (12 mg/m 2 ) was safely combined with Cbz 20 mg/m 2 , a dose with demonstrated activity in mCRPC and potentially less hematologic toxicity than 25 mg/m 2 . Preliminary efficacy data are encouraging with durable responses observed in a subset of pts. Further study of the treatment combination is warranted. Clinical trial information: NCT01594918.
Orthopaedic Appliances Atlas: A Consideration of Aids Employed in the Practice of Orthopaedic Surgery. Volume I: Braces, Splints, Shoe Alterations
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Bakteriologie der Salmonella-Gruppe. (Typh us-Paratyph us-Enteritis-Gruppe)
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantities of Lead Producing Health Effects in Humans: Sources and Bioavailability
Authors: Kathryn R. Mahaffey
Journal: Environmental Health Perspectives (1977)

Levels of lead ingestion and inhalation producing increased body burden of lead and clinical toxicity in adults and children are compared with usual levels of exposure. The magnitude of lead exposure from air, water, and food is estimated. Sources of high level exposure to lead are described; urban street dirt, house dust, and paint are particularly common sources of high concentrations of lead. The bioavailability of different lead compounds is reviewed as well as factors affecting susceptibility to lead.
Magnesium Toxicity
Authors: Daniel Stowens
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In their article "Magnesium Sulfate Enema in a Newborn" (224:1392, 1973), Outerbridge et al demonstrate the toxicity of this metal. In doing so, however, they appear to confuse the misuse of medication with its effects when used in therapeutic quantities, and they further condemn the physiologic rationale on which the treatment was based. Specifically, they note that the infant they describe received 100 ml of a 50% solution of magnesium sulfate by enema, whereas in the initial publication on this subject (<i>Am J Clin Pathol</i>44:259, 1965) the amount recommended was 15 ml. This is almost a sevenfold overdosage. It may be pure coincidence, but the 100-ml dose is precisely that which was used in a study that purported to show the toxic reactions of magnesium sulfate in newborn lambs, animals markedly smaller than newborn infants (<i>Lancet</i>2:64,1965). Overdosage of this magnitude of any substance, even water,
A comparative study of bronchodilator effects of carbuterol and ephedrine
Authors: T. D. James
Journal: JAMA (1979)

The bronchodilator effect of carbuterol hydrochloride, a new adrenergic agonist, was compared with that of ephedrine sulfate in 12 patients with bronchial asthma. A 2-mg dosage of carbuterol hydrochloride, three times daily, was used in comparison with a 25-mg dosage of ephedrine sulfate, three times daily. The drugs were orally administered for ten-day periods in a double-blind, randomized manner. After carbuterol therapy, the mean increases in forced expiratory volume in one second and midmaximal expiratory flow rate were significantly greater in a four-hour period than those noticed with ephedrine. A decrease in bronchodilator response to both drugs was noticed on the tenth day. No side effects were noticed with carbuterol at the aforementioned dosage. The results of our study indicate that carbuterol is a safer and more effective bronchodilator than ephedrine. (<i>JAMA</i>241:704-707, 1979)
Abluminal Release and Asymmetrical Response of the Rabbit Arterial Wall to Endothelium-Derived Relaxing Factor
Authors: Eberhard Bassenge, Rudi Busse, Ulrich Pohl
Journal: Circulation Research (1987)

A marked functional polarity of endothelial cells as well as an asymmetry of the vascular wall in response to vasoactive compounds is well established.Therefore, we investigated the polarity of endothellum-derived relaxant factor (EDRF) release from native endothelial cells, its diffusion characteristics, and its dilator effects on inner and outer muscle layers of the vascular wall in isolated rabbit arteries.Following exposure of rabbit aortae (with intact endothelium) to the EDRF stimulators acetylcholine, A23187, or thimerosal, a humoral dilator compound could be assayed in the adventitial superfusate of the vessels.The vasodilator effects were blocked by the EDRF inhibitors hemoglobin, dithiothreitol, and gossypol.Penetration of the dilator through the arterial wall following stimulation by acetylcholine, A23187, or thimerosal was observed only when dilator EDRF activity in the luminal perfusate was maximal.Luminally administered EDRF, released from cultured endothelial cells, did not cross the aortic wall in detectable amounts.EDRF (from cultured cells) elicited significantly smaller dilations (9 ±4%) when applied to the adventitial side of endothelium-denuded rabbit aortae or femoral arteries as compared with luminal application (92 ±7%).In contrast, sodium nitroprusside was equieffective by both routes of administration.We conclude that EDRF in native endothelial cells is released in both luminal and abluminal directions and can penetrate the entire vascular wall.However, the lengthy diffusion time and the decreasing sensitivity of outer smooth muscle layers suggest that mechanisms other than EDRF diffusion contribute significantly to the propagation of endothelium-mediated relaxation through the arterial wall.(
GROUP PRACTICE; DIAGNOSTIC AND PAY CLINICS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thromboembolism and cor pulmonale complicating ventriculovenous shunt
Authors: B. E. Favara
Journal: JAMA (1967)

NEUROSURGICAL attempts at establishing shunts from the cerebroventricular system to various sites have met with remarkable success in the management of hydrocephalus. In some cases where drainage is from cerebral ventricle to the superior vena cava or right atrium sepsis or thromboembolism, or both, have been observed as serious complications. We have observed a child in whom cor pulmonale occurred in this way and in whom the autopsy findings suggest a pathogenic mechanism to our knowledge not previously emphasized. <h3>Report of a Case</h3> A white boy was first admitted to this hospital on Oct 25, 1965 at 3 years and 8 months of age, for surgical correction of a right acetabular defect. He was born by breech delivery and required resuscitation (birth weight was 4,091 gm [9 lb]). At 9 days of age a congenital meningomyelocele was repaired and at 2 weeks of age bilateral club feet were corrected surgically.
Decreased Expression of Natriuretic Peptides Associated with Lipid Accumulation in Cardiac Ventricle of Obese Mice
Authors: Emil Daniel Bartels, Jan Møller Nielsen, Line Stattau Bisgaard, Jens P. Goetze, Lars Bo Nielsen
Journal: Endocrine Reviews (2010)

Plasma B-type natriuretic peptide (BNP) and proBNP are established markers of cardiac dysfunction. Even though obesity increases the risk of cardiovascular disease, obese individuals have reduced plasma concentrations of natriuretic peptides. The underlying mechanism is not established. We used cultured cardiomyocytes and three different mouse models to examine the impact of obesity and cardiac lipid accumulation on cardiac natriuretic peptide expression. The cardiac ventricular expression of atrial natriuretic peptide (ANP) and BNP mRNA and ANP peptide was decreased 36-72% in obese ob/ob, db/db, and fat-fed C57BL/6 mice as compared with their respective controls. The db/db and ob/ob mice displayed impaired cardiac function, whereas the fat-fed mice had almost normal cardiac function. Moreover, the ventricular expression of hypertrophic genes (α- and β-major histocompatibility complex and α-actin) and natriuretic peptide receptor genes were not consistently altered by obesity across the three mouse models. In contrast, cardiac ventricular triglycerides were similarly increased by 60-115% in all three obese mouse models and incubation with oleic acid caused triglyceride accumulation and an approximately 35% (P &amp;lt; 0.005) depression of ANP mRNA expression in cultured HL-1 atrial myocytes. The data suggest that obesity and altered cardiac lipid metabolism are associated with reduced production of ANP and BNP in the cardiac ventricles in the setting of normal as well as impaired cardiac function.
Predicting psychosocial well-being in head and neck cancer (HNC)
Authors: K. A. Dwyer, B. A. Murphy, A. J. Cmelak, C. Chung, B. B. Burkey, J. L. Netterville, W. Yarbrough, M. R. McDowell
Journal: Journal of Clinical Oncology (2004)

5538 Background: Head and Neck cancer is associated with numerous tumor and treatment related sequelae that affect function, quality of life and psychosocial well-being. Coping styles may affect these outcomes. We conducted a cross sectional, descriptive study of HNC patients across the trajectory of diagnosis and treatment to examine the relationship between coping patterns and biopsychosocial outcomes. Methods: 99 patients completed the following: the Vanderbilt Multi-dimensional Coping Inventory, the Vanderbilt Head and Neck Symptom Survey, the EORTC HN 35, the Center for Epidemiology-Depression, the Impact of Illness Events Scale, the Psychological Vulnerability Scale, and the Brief Religious Coping Scale. Results: Patient characteristics: mean age - 55 (range 21–89 years), educational level 13 years (7–21), 75% male, 93% white, 70% married, 41% employed, 12% currently using a feeding tube. Using hierarchical cluster analysis, two distinctive coping profiles were identified. Cluster 1 used active coping strategies; cluster 2 used low levels of coping strategies. Differences between the two clusters were noted in: use of planful problem solving, distraction, wishful thinking, positive reframing, acceptance and turning to religion. The groups did not differ in the overall report of symptoms, depressive symptoms, perceived health competence or their overall rating of well-being. Separate regression analyses were conducted to identify the best predictors of well-being within clusters. In cluster 1, weight loss and negative religious coping explained 58% of the variance in well-being. For cluster 2, symptom burden, depressed mood, and perceived health competence explained 78% of the variance in well-being. Conclusions: Unlike patients who use “active coping” methods, the global well being of patients with minimal coping skills is affected by symptom burden. Interventions to enhance coping strategies in this group of patients should be designed in order to minimize this effect. No significant financial relationships to disclose.