tbuckley/cabot-search huggingface dataset:
Reproductive toxicology. Ethoxyacetic acid.
Authors: James Lamb, Dushyant Gulati, Leta Hommel, Valerie Russell, P Sabharwal
Journal: Environmental Health Perspectives (1997)

CH3-CH2 -O-CH2-C-OH Ethoxyacetic acid (EAA), the active metabolite of 2-ethoxyethanol (a widely used glycol ether), was tested to assess its effects on reproduction in Swiss CD-I mice using the RACB protocol (Morrissey et al., Fundam Appi Toxicol 13:747-777 [1989]).This was performed as part of a larger struc- ture-activity program, evaluating numerous glycol ethers and their metabolites.From the range finding study (Task 1), doses of 0.2, 0.6, and 1.0% in water were selected for the continuous breeding phase of the study.These concentrations produced esti- mated average doses of approximately 303, 669, and 968 mg/kg/day.Four female mice died during Task 2, two each in the middle and high dose groups.The deaths were due to partnerinduced wounds.In Task 2, high dose mice gained less weight than the other mice so that at necropsy, body weights were reduced by approximately 13%.The number of litters per pair was reduced by 19% at the high dose, while the number of live pups per litter was decreased at both the middle dose (25%) and high dose
Prognosis in persons with an HFE-mutation: population-based cohort study of 3,645 individuals
Authors: Hannes Hagström, Nelson Ndegwa, Mattias Ekstedt, Iris Posserud, Fredrik Rorsman, Nils Nyhlin, Daniel Klintman, Mårten Werner, Hanns-Ulrich Marschall, Johan Askling, Per Stal
Journal: Journal of Hepatology (2020)
Femoral Hernia
Authors: J. Scholefield
Journal: BMJ (1948)

<h3>Abstract</h3> In the study on the transmission of pine wood nematodes by <i>Arhopalus rusticus</i>, we research the ability and characteristics of <i>Arhopalus rusticus</i> to transmit pine wood nematodes. A total of 288 <i>Arhopalus rusticus</i> (female 142, male 146) were collected and 20 (female 8, male 12) of them were able to carry pine wood nematodes. Results shown that 12 beetles can transmit pine wood nematodes. <i>Arhopalus rusticus</i> does not eat the pine bark, but eat the pine needles. Pine wood nematodes are transmitted through the feeding bite mark on the pine needles. In addition experiments further confirmed that pine wood nematodes could transmit through pine needles.
“Detection of SV40 like viral DNA and viral antigens in malignant pleural mesothelioma.” M. Ramael, J. Nagels, H. Heylen, S. De Schepper, J. Paulussen, M. De Maeyer and C. Van Haesendonck. Eur Respir J 1999; 14: 1381–1386.
Journal: European Respiratory Journal (2020)
Clinical Pharmacol &amp;amp; Therapeutics, St. Louis
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nodding Syndrome Still Mystifies
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Relative Influence of Calcium Intake and Vitamin D Status on Serum Parathyroid Hormone and Bone Turnover Biomarkers in a Double-Blind, Placebo-Controlled Parallel Group, Longitudinal Factorial Design
Authors: John Aloia, Trajko Bojadzievski, Eleanor Yusupov, Ghulamullah Shahzad, Simcha Pollack, Mageda Mikhail, James Yeh
Journal: Endocrine Reviews (2010)

Adequate calcium and vitamin D are needed to maintain calcium balance. Our objective was to examine the influence of calcium intake and vitamin D exposure separately and their interaction on biomarkers of calcium sufficiency. Healthy men and women, age 20–80 yr, were randomly allocated to four groups: 1) double placebo, 2) calcium (1200 mg daily) plus placebo, 3) vitamin D3 (100 μg) plus placebo, and 4) vitamin D3 and calcium. Fasting serum and urine as well as serum and urine 2 h after a calcium load (600 mg of calcium carbonate) were obtained at baseline and 3 months. Ninety-nine participants were randomized; 78 completed the study. Baseline demographics, protein intake and laboratory studies did not differ among the four groups. Study medication compliance was 90%. Fasting bone turnover markers declined after 3 months only in the two groups given calcium supplements and increased in the vitamin D3 plus placebo calcium group. The calcium load resulted in a decrease in PTH and in bone turnover markers that did not differ among groups. Urinary calcium excretion increased in the combined group. Mean serum 25-hydroxyvitamin D increased from a baseline of 67 (18) nmol/liter to 111 (30) nmol/liter after vitamin D supplementation. Increased habitual calcium intake lowered markers of bone turnover. Acute ingestion of a calcium load lowered PTH and bone turnover markers. Additional intake of 100 μg/d vitamin D3 did not lower PTH or markers of bone turnover.
Editorial Board
Authors: Rhiannon Macrae, Milka Kostic, Basil Nyaku, Ria Otten, Patrick Scheffmann, S Gasser, Y Hayashizaki, S Henikoff, J Hodgkin, H Horvitz, Usa Cambridge, E Hurst, E Meyerowitz, S Moreno, Sika Zheng, Douglas Black, Satoshi Yamazaki, Motoshi Hayano, Hisao Masai, Shi-Yan Ng, Lin Lin, Seng Soh, Lawrence Stanton, Katherine Helliwell, Glen Wheeler, Alison Smith, Vladislav Grishkevich, Itai Yanai, G Farrar, Naomi Chadderton, Paul Kenna, Sophia Millington-Ward, Eric Bapteste, Leo Van Iersel, Axel Janke, Scot Kelchner, Steven Kelk, James Mcinerney, David Morrison, Luay Nakhleh, Mike Steel, Leen Stougie, James Spotlight
Journal: Trends in Genetics (2013)
AN X-RAY DANGER.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LETTER FROM PARIS.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatrists, Journalists Hold Their First Meeting of Minds
Authors: A. A. Skolnick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1733: Role of the SIX1 oncofetal protein in endometrial basal cell metaplasia and carcinogenesis following neonatal exposure to diethylstilbestrol
Authors: Alisa A. Suen, Wendy N. Jefferson, Charles E. Wood, Anna C. Kenan, Carmen J. Williams
Journal: Cancer Research (2019)

Abstract Early-life exposure to estrogenic chemicals can increase cancer risk, likely by disrupting normal patterns of cellular differentiation. In a model of this process, female mice exposed to the potent synthetic estrogen diethylstilbestrol (DES) on postnatal days 1-5 develop endometrial adenobasal carcinoma as adults. Neoplastic glands are comprised of abnormal populations of basal cells (cytokeratin (CK)14+), luminal cells (CK18+), and low numbers of "mixed” basal/luminal cells (CK14+/18+), all of which express the oncofetal protein sine oculis homeobox 1 (SIX1). We hypothesized that DES-induced SIX1 expression is necessary for aberrant endometrial differentiation patterns and carcinogenesis. To test this hypothesis, a conditional knockout model was generated in which floxed Six1 was excised in the uterus using progesterone receptor (Pgr) cre. The most prominent change in DES-exposed SIX1 knockout (DES-Six1d/d) mice was the absence of basal cells in the uterine horns. There was a greater than 10-fold decrease in CK14 labeling in the uterine horns of DES-Six1d/d mice compared to DES-exposed SIX1 wildtype (DES-Six1+/+) mice as determined by quantitative image analysis. However, DES-Six1d/d mice exhibited a 42% increase in cancer incidence compared to DES-Six1+/+ mice at 6 months of age (16/18 DES-Six1d/d vs. 7/15 DES-Six1+/+). Interestingly, mixed cells were still present in DES-Six1d/d mice. These findings demonstrate that SIX1 is a cellular differentiation factor necessary for DES-induced basal cells but not mixed cell development or cancer. Furthermore, these data suggest that DES-induced SIX1 expression decreases endometrial carcinogenesis by facilitating basal cell differentiation. Studies investigating the mixed cell population as a putative cancer progenitor cell population are ongoing. Interestingly, mixed cells were present in 35% (63/181) of malignant human endometrial tissue biopsies and in 0% (0/29) of normal endometrial tissue biopsies, suggesting that the DES mouse model has significant similarities to human endometrial cancer. Citation Format: Alisa A. Suen, Wendy N. Jefferson, Charles E. Wood, Anna C. Kenan, Carmen J. Williams. Role of the SIX1 oncofetal protein in endometrial basal cell metaplasia and carcinogenesis following neonatal exposure to diethylstilbestrol [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1733.
Radiologic Aspects of Renovascular Hypertension
Authors: Mark D. Reiss
Journal: JAMA (1972)

In the Cooperative Study of Renovascular Hypertension, 2,719 renal arteriograms were performed. Initial studies were done in 2,374 patients, and 345 studies were done on a follow-up basis. The transfemoral catheter technique was used in 77% of the cases. There was a fatality rate of 0.11% and a nonfatal major complication rate of 1.2%. Most of the major complications involved hemorrhage, thrombosis, and renal injury. These did not appear to be related to the technique utilized.
Estrogens in Unexpected Places: Possible Implications for Researchers and Consumers
Authors: David Feldman, Aruna Krishnan
Journal: Environmental Health Perspectives (1995)

Estrogenic activity originating in unexpected places was encountered on three occasions during an investigation of whether Saccharomyces cerevisiae synthesized estrogens.In each instance, estradiol found in the conditioned yeast culture medium originated from an exogenous source and was not synthesized by the yeast.In the first instance, yeast grown in the laboratory showed a time-dependent increase in estradiol in the conditioned medium.However, the culture medium supplement Bacto-peptone was found to contain large amounts of estrone.When added to yeast cultures in the form of YPD medium (yeast extract, Bacto-peptone, and dextrose), S. cerevisiae converted the estrone to estradiol leading to the accumulation of estradiol over time.In the second instance, commercially purchased S. cerevisiae grown in a molasses medium exhibited substantial amounts of estradiol.However, corn and beet molasses contained sufficient estrone and estradiol to account for the findings.As in the first instance, the yeast converted the estrone into estradiol.In the third instance, autoclaving culture medium in polycarbonate plastic flasks was found to cause an estrogenic substance to be added to the medium, whether yeast were present or not.It was determined that the autoclaving process leached bisphenol-A (BPA) out of the polycarbonate plastic.BPA was shown to bind to estrogen receptors and to induce estrogenic.activity,including stimulation of MCF-7 breast cancer-cell proliferation and induction of the expression of progesterone receptors.The three instances highlight potential problems for investigators who might inadvertently add estrogens to experimental systems confounding their results.The BPA findings raise concerns about the possible addition of this estrogenic molecule to the food supply since polycarbonate plastic is used in myriad applications in the packaging of food and beverages.Although we are unaware of the substantial contamination of food products with BPA, we believe this possibility should be carefully investigated.-
'Cardiac Arrest'
Authors: Frank Cole
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Three parts of the title "Unexpected Cardiac Arrest During Anesthesia and Surgery" (236:2758,1976) lend themselves separately to criticism. First, cardiac arrest is always unexpected; when does one put a patient to sleep and expect that he will die? Second, I have said repeatedly that there is no such disease as cardiac arrest, and that the name should be removed from the literature. If the heart is made to stop because of respiratory obstruction, hypoventilation, anesthetic mismanagement, or embolus, this is all we need to say. It serves no purpose to invent another diagnosis and to say that a mysterious disease struck down the patient. Hearts do not stop without cause and without warning. The incidence of what is called "cardiac arrest" is sometimes the incidence of mind-wandering and inattention, or the incidence of lack of skill or mismanagement. The authors speak of aspiration of vomitus, inappropriate use
Experimental Immunochemistry
Authors: Ernest Witebsky
Journal: JAMA (1962)

The long-awaited second edition of Kabat and Mayer's book has now appeared. It has actually been rewritten by Kabat, with a long and highly-detailed chapter on complement and complement fixation (and one on the Kjeldahl nitrogen method) by Mayer. Since the first edition appeared in 1948, the science of immunochemistry, as a specialized approach to immunology, has progressed enormously and developed many areas of subspecialty. The growth of important knowledge is well shown by the fact that the original 550 pages have been expanded to 900. The very same chapter topics have been used but they have been expanded and modernized, some of them very considerably. A few new chapters have been added in order to handle such interim developments as the uses of radioactivity and chromatography. The 64 chapters are divided into 4 groups, as follows: Immunological and immunochemical methodology; applications and uses of quantitative immunochemical methods; chemical and
Self-heard venous hums
Authors: J. E. Hardison
Journal: JAMA (1981)

We describe two patients with symptomatic, self-heard venous hums. The venous hum was secondary to chronic anemia in one patient and was idiopathic in the other. The idiopathic hum was not heard in the neck but could be heard by auscultating the right auditory canal. Ligation of the right internal jugular vein abolished the idiopathic hum, which had been present for 14 years. (<i>JAMA</i>1981;245:1146-1147)
Risks and Benefits of Screening for Intracranial Aneurysms in First-Degree Relatives of Patients with Sporadic Subarachnoid Hemorrhage
Authors: The Magnetic Resonance Angiography in Relatives of Patients with Subarachnoid Hemorrhage Study Group
Journal: New England Journal of Medicine (1999)

The first-degree relatives of patients who have subarachnoid hemorrhage from ruptured intracranial aneurysms are themselves at risk for subarachnoid hemorrhage. We studied the benefits and risks of screening for aneurysms in the first-degree relatives of patients with sporadic subarachnoid hemorrhage.
Hepatitis B virus infection in high-risk inner-city neighborhoods in San Francisco*1
Authors: D SIEGEL
Journal: Hepatology (1995)

To examine the extent of hepatitis B virus infection (HBV) in an inner-city community, we determined the prevalence, incidence, and correlates of HBV seroreactivity in a representative sample of unmarried whites, African-Americans, and Hispanics living in San Francisco during 1988 to 1989 and again 1 year later in 1989 to 1990. Unmarried men and women aged 20 to 44 years were surveyed in a random household sample drawn from three neighborhoods of varying geographic and cultural characteristics. Hepatitis B infection was determined by testing specimens for antibody to hepatitis B core antigen (anti-HBc). Of blood samples available from 1,108 participants from the initial survey, 159 (14%) were anti-HBc positive. There was a strong positive association between anti-HBc positivity and positive serological tests for human immunodeficiency virus, herpes virus type 2, and syphilis. In women and heterosexual men, after controlling for other variables, anti-HBc positivity was significantly associated with older age (P < .001), nonwhite ethnicity (P < .01), less education (P < .05), injection drug use (P < .001), being paid for sex (P < .05), and lifetime number of sexual partners (P < .05). Among homosexually active men, after controlling for other variables, anti-HBc positivity was significantly associated with nonwhite ethnicity (P < .001), injection drug use in a sexual partner (P < .05), and number of lifetime sexual partners (P < .05). There were 19 (3.2%) incident HBV infections. Participants who used injection drugs (relative risk [RR], 8.2; 95% confidence interval [CI] 3.9 to 17.4), crack cocaine (RR, 3.5; 95% CI, 1.2 to 9.6), or who were paid for sex (RR, 7.6; 95% CI, 1.4 to 41.1) were more likely to have recently acquired HBV than participants who did not practice these activities. HBV antibodies were found in 14% of an ethnically diverse community based sample, and in general were associated with serological evidence of and risk behaviors for sexually transmitted diseases as well as with injection drug use. Subjects with incident compared with those with prevalent HBV infections were younger, more commonly heterosexual, and more commonly illicit drug users.
Endoscopic electrosurgical papillotomy and manometry in biliary tract disease
Authors: J. E. Geenen
Journal: JAMA (1977)

Endoscopic papillotomy was performed in 13 patients after cholecystectomy for retained or recurrent common bile duct calculi (11 patients) and a clinical picture suggesting papillary stenosis (two patients). Following endoscopic papillotomy, ten of the 11 patients spontaneously passed common bile duct (CBD) stones verified on repeated endoscopic retrograde cholangiopancreatography (ERCP) study. One patient failed to pass a large CBD calculus; one patient experienced cholangitis three months after an inadequate papillotomy and required operative intervention. Endoscopic papillotomy substantially decreased the pressure gradient existing between the CBD and the duodenum in all five patients studied with ERCP manometry. Endoscopic papillotomy is a relatively safe and effective procedure for postcholecystectomy patients with retained or recurrent CBD stones. The majority of CBD stones will pass spontaneously if the papillotomy is adequate. (<i>JAMA</i>237:2075-2078, 1977)