tbuckley/cabot-search huggingface dataset:
Unrecognized Legionnaires' disease as a cause of fatal illness
Authors: D. Fay
Journal: JAMA (1980)

Lungs from 224 patients, obtained at autopsy, were examined for<i>Legionella pneumophila</i>by fluorescent antibody (FA) staining. Of 121 patients who died with pneumonia,<i>L pneumophila</i>was present in eight cases (6.6%). Two of the eight patients exhibited no important respiratory symptoms or fever, although pneumonia contributed considerably to their deaths. Preexisting underlying disease was present in all cases. Legionnaires' disease (LD), endemic in the central Ohio area, may cause up to 3.6% of the nosocomial pneumonias at the study site. Application of the local incidence of LD to the number of annual adult deaths in the United States indicates that many LD-associated deaths may occur each year. The study shows the importance of using the FA and Dieterle stains during routine pathological examination of lung tissue, especially from compromised hosts in endemic areas. (<i>JAMA</i>243:2311-2313, 1980)
Journal reviews in JAMA
Authors: D. Eakin
Journal: JAMA (1992)

Have you looked for the latest developments in AIDS research, the results of clinical trials of an experimental drug, a critical review of vascular imaging techniques, or case reports of a rare syndrome? These and similar questions routinely prompt practitioners to consult the clinical journal literature. Journals are also essential tools for keeping up in a specialty, but we hear the frequent lament that there are too many journals. The 2960 journals indexed by the National Library of Medicine for<i>Index Medicus</i>and MEDLINE represent only a fraction of the world's biomedical literature. With scores of new journals being started each year, keeping up is a formidable task. See also p 158. Not only have the number and specialization of journals increased, but subscription prices have risen rapidly in recent years. Unfortunately, the budgets of neither libraries nor individuals have kept pace. With more journals to choose from and with
Leg scanning with radioisotope-labeled fibrinogen in patients undergoing hip surgery. Comparison with contrast phlebography and lung scans
Authors: J. R. LeMoine
Journal: JAMA (1980)

To establish whether radioisotope-labeled fibrinogen leg scanning is of value in the context of hip surgery, we prospectively studied 21 consecutive patients undergoing either total hip replacement (14) or open repair of a hip fracture (seven) with leg scans, contrast phlebography, and ventilation and perfusion lung scans. We found that in eight patients (38%), venous thromboembolism developed postoperatively. Agreement between phlebographic and leg scanning results was excellent. In no patient was venous thrombosis limited to the thigh on the operated-on side, a vital consideration in application of fibrinogen leg scanning to this patient population. Two patients had lung scan changes indicative of embolism; both had thrombi extending into thigh veins. Leg scanning with radioisotope-labeled fibrinogen appears to be a useful method for monitoring patients undergoing hip surgery, if the upper three counting points on the operated-on side are excluded. (<i>JAMA</i>243:2035-2037, 1980)
Chest Deformities
Authors: P. A. Zorab
Journal: BMJ (1966)

<h3>Abstract</h3> The severity of neuronal damages in comatose patients following anoxic brain injury can be probed by evoked auditory responses. However, it remains challenging to predict the return to full consciousness of post-anoxic coma of hospitalized patients. We presented here a method to predict the return to consciousness based on the analysis of periodic responses to auditory stimulations, recorded from surface cranial electrodes. The input data are event-related potentials (ERPs), recorded non-invasively with electro-encephalography (EEG). We extracted several novel features from the time series responses in a window of few hundreds of milliseconds from deviant and non-deviant auditory stimulations. We use these features to construct two-dimensional statistical maps, that show two separated clusters for recovered (conscience) and deceased patients, leading to a high classification success as tested by a cross-validation procedure. Finally, using Gaussian, K-neighborhood and SVM classifiers, we construct probabilistic maps to predict the outcome of post-anoxic coma. To conclude, statistics of deviant and non-deviant responses considered separately provide complementary and confirmatory predictions for the outcome of anoxic coma.
Safety and efficacy of FOLFOXIRI with or without targeted agents as first-line treatment of selected elderly metastatic colorectal cancer patients: a pooled analysis of GONO studies
Authors: D. Rossini, M. Casagrande, R. Moretto, F. Loupakis, C. Cremolini, G. Masi, B. Borelli, S. Lonardi, V. Zagonel, G. Aprile, V. Ricci, R. Grande, G. Tomasello, M. Ronzoni, G. Allegrini, G. Tonini, M.L. Mancini, A. Zaniboni, S. Chiara, C. Carlomagno, A. Falcone
Journal: Annals of Oncology (2016)
Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration
Authors: Daniel F. Martin, Maureen G. Maguire, Stuart L. Fine, Gui-shuang Ying, Glenn J. Jaffe, Juan E. Grunwald, Cynthia Toth, Maryann Redford, Frederick L. Ferris
Journal: Ophthalmology (2020)
“Lung cancer survival in Norway, 1997–2011: from nihilism to optimism.” Yngvar Nilssen, Trond Eirik Strand, Lars Fjellbirkeland, Kristian Bartnes and Bjørn Møller. <i>Eur Respir J</i> 2016; 47: 275–287.
Journal: European Respiratory Journal (2016)

In table 2 of the aforementioned article from the January 2016 issue of the European Respiratory Journal, there were some errors in the confidence intervals regarding the variable smoking.The correct estimates should have been the following.For all patients; multivariate analysis: Current smokers: 1.18 (1.09-1.28)instead of 1.18 (0.94-1.03)Former smokers: 1.06 (0.98-1.16) instead of 1.06 (0.97-1.13)For resected lung cancer patients; multivariate analysis: Current smokers: 1.25 (0.87-1.80) instead of 1.25 (0.87-1.01)Former smokers: 1.07 (0.73-1.57) instead of 1.07 (0.73-1.26)Table 2 has been corrected and the online version of the article updated.
Pancreatic abscess with Haemophilus influenzae and Eikenella corrodens
Authors: L. I. Lutwick
Journal: JAMA (1976)

An infected pancreatic pseudocyst was caused in part by<i>Haemophilus influenzae</i>and<i>Eikenella corrodens</i>. To my knowledge, neither organism has been isolated previously from pancreatic abscesses. I believe that the infecting bacteria originated in the oropharynx and descended through the duodenum. (<i>JAMA</i>236:2091-2092, 1976)
LEGISLATION IN GEORGIA.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Johann Wolfgang von Goethe
Authors: Rüdiger Kratz
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I much appreciated the note on Johann Wolfgang von Goethe by M. A. Shampo and R. A. Kyle in a recent issue (235:2104,1976), since he is without doubt the foremost German writer and, as indicated, a true<i>Universalgenie</i>, a universal genius. To call Goethe a "romanticist and sentimentalist," however, does not quite do justice to such reflective-philosophical works as 'Faust II' or 'Westöstlicher Diwan.' At least in German, these words imply too much the idea of a dreamer and a man out of contact with reality, which he, as a minister at the court of Weimar, certainly was not. Goethe's birthplace is Frankfurt am Main, which is in Hessia, not Prussia. He spoke a perfect Hessian dialect, and even in 'Faust' he occasionally rhymes in it, whether consciously or not, I do not know. By the way, Schiller's career as a military physician was forced on him,
The hospital 'surgical signature'. A quality-assessment tool
Authors: R. E. McAfee
Journal: JAMA (1987)

The credibility and ultimate success of programs that address variations in practice patterns and the utilization of health care are entirely dependent on a continuing source of reliable data. In existing programs that monitor geographic variations in health care utilization, physician response has been most favorable when the data allow comparison of populations and treatment modalities most similar to their own practice experience. Data that will identify not only current practice patterns, but also trends over time, are critical to the success of such programs; noteworthy examples are the Maine Medical Assessment Project and a similar program in Iowa sponsored by the Iowa State Medical Society in concert with the state hospital association. Wennberg et al,<sup>1</sup>in this issue ofThe Journal, have alerted us to such a continuing source of data derived from Medicare fiscal intermediaries, and possibly available from other commercial carriers. These data are population based,
Device-specific risk of needlestick injury in Italian health care workers
Authors: G. Ippolito
Journal: JAMA (1994)

<h3>Objectives.</h3> —To identify the types of medical devices causing needlestick injuries among Italian health care workers, to document the device-specific injury rates and time trends for different hollow-bore needles, and to compare injury rates from these devices with those reported in the United States. <h3>Design.</h3> —Longitudinal survey. <h3>Settings.</h3> —Twelve Italian acute care public hospitals. <h3>Methods.</h3> —Data were obtained from a multihospital surveillance database on the number of total injuries reported in each device category. Hospitals provided the corresponding number of devices used annually for each needle type. <h3>Main Outcome Measure.</h3> —Number of needlestick injuries by type of hollow-bore needle per 100000 devices used per year. <h3>Results.</h3> —A total of 2524 injuries from hollow-bore needles were reported. Disposable syringes/hypodermic needles accounted for 59.3% of injuries, followed by winged steel needles (33.1%), intravenous catheter stylets (5.4%), and vacuum-tube phlebotomy needles (2.2%). Intravenous catheter stylets had the highest needlestick injury rate (15.7/100 000 devices used), and disposable syringes had the lowest needlestick injury rate (3.8/100 000). In contrast to the other devices, the injury rate from winged steel needles increased from 6.2 per 100 000 in 1990 to 13.9 per 100000 in 1992. <h3>Conclusions.</h3> —The device-specific needlestick injury rates in Italy are similar to those reported in the United States, suggesting similar exposure experience in two countries. However, in contrast to the United States, needleless intravenous access is standard practice in Italy and thus eliminates one potential risk to Italian health workers. Implementation of safer equipment, such as shielded or retracting needles, and continuing training programs are needed to further reduce the hazards that health care workers face. (<i>JAMA</i>. 1994;272:607-610)
PSYCHO-ANALYSIS
Authors: Chas. Mercier
Journal: BMJ (1914)

Onie can distiliguish.I think.thlrce sorts of cases in wlhichl removal of the appenidix is constantly beiig advisefd or performu-edI witlh doubtful justification.These are casebs of so-called '-appenidix d.yspepsia "; secondly, cases of clhroic ipain or dis- comltfort in thle riglht iliac fossa; anid, thirdlyv, cases of vague ill lhealtlh, in which the patient " lools toxic."The followina case mighlt reasonably be iniclud(led iii the second class:The patient, a strong, healthy-looking girl, 22 years of age, came to me about the beginning of Septenmber complaining of occasionial pain iii tlhe right side of the abdom--en lasting for a fewv houirs and theni abatinlg.She stated that she sometimnes felt it dowvn the right-leg.There was nio historv of any acute illniess; inideed, the patienit had seldom-l lbeen a day in bed.Menstruation was irregular.Oni September 14th I examined the patien1t in bed, alnd oii inispectiiing tlie ab(lomzeni was struck by the marlked growtlh of hair extendilniig up to the ulrubilicnu.Paipationi elicited teniderness oni the riglit si(le.most
OP0272 Identification of New Inhibitors of Angiogenesis in A Novel 3d Model of Rheumatoid Arthritis Synovial Angiogenesis
Authors: C.X. Maracle, P. Kucharzewska, B. Helder, H. Olsson, S.W. Tas
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Angiogenesis contributes to rheumatoid arthritis (RA) pathogenesis, however, many models focus solely on endothelial cells (EC). We developed a 3D-spheroid model including both EC and RA fibroblast-like-synoviocytes (FLS) to study angiogenesis associated with RA and to test the efficacy of several inhibitors targeting this process. Previous work demonstrated a role for the non-canonical NF-κB pathway and its main regulator, NF-kB inducing kinase (NIK), in pathological angiogenesis and thus we aim to use the 3D model to further characterize its contribution to neovascularization. <h3>Objectives</h3> Generate a representative 3D <i>in vitro</i> model of RA synovial angiogenesis and screen the effects of targeting the non-canonical NF-κB pathway using siRNA or small molecule pharmacological inhibitors. <h3>Methods</h3> Human primary EC were co-cultured with RA FLS after pre-incubation with cell tracker dyes and incubated overnight to form spheroids. Subsequently, spheroids were plated in collagen gel and stimulated with 10% RA SF, growth factors (GF) or well-known activators of non-canonical NF-kB signaling (lymphotoxin beta (LT) or LIGHT). To establish NIK dependency, EC were pre-transfected with NIK-targeting siRNA before incorporation into spheroids. Furthermore, several pharmacological inhibitors were screened for their ability to block sprout formation. Spheroids were imaged by confocal microscopy and quantified using Leica QWin Plus software. <h3>Results</h3> We established a robust 3D model of angiogenesis containing both EC and RA FLS. LT, LIGHT, RA SF and GF stimulations led to significant increases in sprout formation as compared to basal conditions (p&lt;0.05). The LT and LIGHT induced sprout formation proved to be NIK dependent as spheroids containing EC transfected with NIK targeting siRNA had significant reductions in vessel formation as compared to the non-targeting controls (p&lt;0.05). Sprouting promoted by GF and RA SF was significantly blocked by the angiogenesis inhibitor Anginex (p&lt;0.05). Finally, targeting of the non-canonical pathway using a small molecule pharmacological NIK inhibitor significantly reduced sprout formation caused by LT and LIGHT, and importantly also RA SF-induced sprout formation (p&lt;0.05). <h3>Conclusions</h3> We developed a novel 3D model that incorporates essential elements of synovial inflammation, namely EC, RA FLS and RA SF, which proves to be an effective tool for studying synovial angiogenesis. Using this system, we have further demonstrated a role for the non-canonical NF-kB pathway, and its central regulator NIK, in neovascularization associated with RA. Moreover, we have shown that the 3D model is useful for testing small molecule inhibitors of angiogenesis and found that targeting non-canonical NF-kB signaling is an effective method to block pathological angiogenesis. <h3>Disclosure of Interest</h3> None declared
Session E: Breast Cancer
Authors: Mariano Cherubini, Attilio Cuviello, Gerardo Guarino, Alessandro Morabno ', Gianfranco Filippelh, Stefano Vitale ', Sergio Palmeri, Tamburo Manuela, Sara De Bella ', Francesco Gilbert! ', Bruno Massida', Stefano Cascinu, Vincenzo Catalano, Giampietro Gasparim, Daniela Turchetti', Giulio Rossi, Laura Cortesi, Chiara Casarini, Lucia Mangone', Sergio Ferrari, Gian Trentini, Massimo Federico, Vittono Silingardi, Francesca Adami, Enrico Aitim, Giovanna Cavazzmi, Maunzio Cantore, Carla Rabbi, Franca Pan, Donatella Zamagni, Marco Sono, Franco Smeneri
Journal: Annals of Oncology (2000)
Meet the First Authors
Journal: Circulation Research (2018)

the University of Milano-Bicocca, specializing in Translational and Molecular Medicine in Antonio Zaza's group, where he explored the electrophysiological properties of adult cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to model cardiac arrhythmias.In 2015, he moved to the Leiden University Medical Center in the Netherlands to work with Christine Mummery's group to improve current in vitro technologies to integrate or replace animal models in disease modelling, drug screening, and drug development with human cells.In 2018, he moved back to Italy to join Peter J. Schwartz's group at IRCCS Istituto Auxologico Italiano to study cardiac channelopathies with hiPSC-CMs and to improve the translational aspects of this promising technology in pursuit of precision medicine.He is in love with science and technology and believes that the strong influence of computers and automation on basic science practice can help scientists solve problems faster, more efficiently, and with tremendous advantages in terms of reproducibility, data sharing, and collaborations.Outside the lab, he loves to hike and bike in the beautiful woods and mountains of Northern Italy.Open Software to Quantify Cardiac Contraction (p e5) Berend van Meer earned his BSc and MSc in Electrical Engineering at Delft University of Technology, where he specialized in Microelectrical Engineering and graduated on a Skin-on-Chip device.In 2014, he started his PhD in Christine Mummery's group to work on Organ-on-Chips and the development of measurement methods for quantifying human pluripotent stem cell-derived cardiomyocytes in response to drugs and disease.He expects to receive his PhD in June 2018.Although the transition from engineer to biologist might seem a bit farfetched, working at the intersection of these disciplines is what he enjoys most.He is a strong believer that combining the expertise of different areas makes complex challenges easier to solve, and that collaboration within research areas speeds up the progress of the field.In his view, collaboration, together with the right (software) tools and knowledge being open and available for everyone, will greatly benefit science.In his free time, Berend enjoys running and playing field hockey.
More from the pesky Pasteurella
Authors: B. E. Beyt
Journal: JAMA (1983)

<i>Pasteurella multocida</i>was first isolated from birds more than 100 years ago, and only recently has the frequency and full clinical spectrum of human infection with this organism been recognized. In this issue, Kalish and Sands (p 514) along with Stein et al (p 508) further expand and elucidate the current clinical problems caused by this pleomorphic gram-negative organism.<i>Pasteurella multocida</i>is primarily an animal pathogen that causes septicemia in many domestic and wild animals, thus deriving the name<i>many killing</i>. In humans, clinical infections can be grouped into one of three types. A local infection may occur after animal-inflicted wounds, preponderantly cat and dog bites and scratches. Severe swelling, erythema, and pain may develop, and the infection is associated with a gray serous or sanguinopurulent discharge.<sup>1</sup>With sharp animal teeth, penetration and inoculation of the synovium and periosteum may result in osteomyelitis or septic arthritis. Among infections not
SCHOOL DISEASES
Authors: EDWIN O. JORDAN
Journal: JAMA (1913)

There is no doubt that children of school age contract such diseases as measles, scarlet fever and diphtheria much more frequently than older persons. Sharp difference of opinion exists, however, as to the actual part played by school attendance in the transmission of these diseases. Some observers maintain that while the maladies in question are diseases of school children, they are not properly to be regarded as school diseases. From this standpoint diphtheria, scarlet fever and the like are especially prevalent among school children, not because school conditions favor their transmission, but simply because children of school age are more susceptible to infection. On the other side are those who hold that school attendance plays a large part if not the chief part in the dissemination of infectious disease among groups of children of susceptible ages. Viewed broadly, there is much to favor the latter opinion. All that has been
The Utility of Prostate-Specific Antigen for Detecting Prostate Cancer
Authors: Kenneth G. Marshall
Journal: JAMA (1995)

<h3>To the Editor.</h3> —An important question that is not addressed in the article by Dr Gann and colleagues<sup>1</sup>is the potential harm that widespread PSA screening could cause. The authors found an overall sensitivity for prostate cancer detection by PSA testing of 46%, with a specificity of 91%. Put another way, 9% of all PSA test results were false positives. According to the authors, archival blood samples were available from 14 916 men. A total of 322 of them developed prostate cancer over the 10-year study period, and 170 of these 322 had a positive PSA test result. If all 14 916 men had had PSA determinations, we would have expected to find 1313 false-positive PSA results among the 14 594 patients who did not develop prostate cancer in addition to the 170 true-positive PSA results among the 322 patients who did develop prostate cancer. This gives the PSA
Long-term alcohol intake enhances ADP-ribosylation of the multifunctional enzyme, phosphoglucomutase, in rat liver
Authors: F Nomura, M Noda, M Miyake, T Nakai
Journal: Hepatology (1996)

Adenosine diphosphate (ADP)–ribosylation is a posttranslational protein modification that, in turn, alters several regulatory proteins in mammalian cells. We demonstrated that long–term alcohol intake enhanced the ADP–ribosylation of a 58–kd protein in rat liver plasma membranes. To assess the biological significance of this phenomenon, we partially purified the 58–kd acceptor protein from solubilized rat liver homogenates by two sequential preparative high–pressure liquid chromatographies. Microsequencing revealed that it was phosphoglucomutase (PGM) (EC 5,4,2,2). This enzyme underwent negligible auto ADP–ribosylation, but the ADP–ribosylation was remarkably increased by adding rat liver plasma membranes. The extent of the increase was greater in alcohol–fed rats than in pair–fed controls, suggesting enhanced enzyme activities toward ADP–ribosylation of PGM after chronic alcohol consumption. Several important enzymes are ADP–ribosylated, after which their activities are modified. The results of this study showed that PGM is a novel substrate for ADP–ribosylation in the liver and that the ADP–ribosylation is increased after chronic alcohol consumption. In view of the variety of roles of PGM in the liver (carbohydrate metabolism and Ca2+ homeostasis), specific roles of this modification in terms of the effects of alcohol on hepatocytes may deserve further investigation.