tbuckley/cabot-search huggingface dataset:
THE MEDICAL COLLEGES OF THE UNITED STATES AND CANADA.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Monoclonal antibody against the CD18 adhesion molecule stimulates glucose uptake by the liver and hepatic nonparenchymal cells
Authors: A Bautista
Journal: Hepatology (1993)

Neutrophils and macrophages play an important role in the body's microbicidal defense and have been implicated in the induction of tissue injury in reperfusion, endotoxemia and septic shock. Cellular host defense is accompanied by enhanced glucose use. In this study we examined the effect of monoclonal antibody 1F12 on in vivo glucose use by selected tissues and hepatic phagocytes. Monoclonal antibody 1F12 is specific for the CD18 adhesion molecule on rat neutrophils and is the only known antibody that induces profound neutropenia. The administration of monoclonal antibody 1F12 at a final dose of 2 mg/kg body weight enhanced the removal of neutrophils from the circulation within 15 min. Leukopenia was sustained for 24 hr. Large numbers of neutrophils were sequestered in the liver at 4 hr. Although the number of neutrophils in the liver at 24 hr after antibody treatment was lower than at 4 hr, these values were still higher than those in the saline controls. The rate of glucose metabolism by selected tissues was not significantly altered by the antibody, except by the liver, in which use increased 2.7-fold vs. the control value at 4 hr after treatment. Hepatocytes, endothelial cells and Kupffer cells contributed to the increase in the rate of glucose metabolism by the liver. The rate of glucose metabolism by Kupffer cells was significantly elevated at 4 and 24 hr, whereas the rate of glucose metabolism of hepatocytes and endothelial cells returned to normal at 24 hr. After antibody treatment, the glucose uptake by hepatic sequestered neutrophils was significantly reduced at 4 hr and returned to near-normal levels at 24 hr. Another CD18 monoclonal antibody (monoclonal antibody WT.3), which does not cause neutropenia, did not alter the glucose uptake by tissues and hepatic cells, although it induced slight sequestration of neutrophils in the liver. The N-formylmet-leu-phe–induced superoxide release by neutrophils was attenuated by monoclonal antibody 1F12 in vitro and in vivo. These data indicate that as a consequence of monoclonal antibody 1F12 treatment, a major portion of the neutrophil pool is found in the liver and that Kupffer cells and endothelial cells become activated. It is postulated that this is part of the mechanism for increased clearance of effete leukocytes from the circulation. (HEPATOLOGY 1993;17:924–931.)
Fetal Anoxia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Preleukemia
Authors: H. PHILLIP KOEFFLER
Journal: Annals of Internal Medicine (1980)

Preleukemia refers to the syndrome of hematopoietic dysfunction seen in some patients before typical features of acute myelogenous leukemia develop. Clinically, preleukemia is characterized by variable degrees of pancytopenia, with associated symptoms due to decreased circulating blood elements. The bone marrow is usually hypercellular, and there are prominent morphologic abnormalities in erythroid precursors and more subtle changes in megakaryocytes and granulocyte progenitors. During this phase of the leukemic process, the neoplastic clone is usually already established and predominant. A clear distinction should be made between the preleukemic syndrome and diseases that predispose to development of acute myelogenous leukemia. Preleukemia, like acute myelogenous leukemia, is a clonal hematopoietic stem cell neoplasm manifested functionally by abnormal hematopoietic cell maturation and ineffective hematopoiesis. During the course of preleukemia, precursor cell maturation becomes progressively impaired with termination in the severe maturational block characteristic of acute myelogenous leukemia. We favor the concept that preleukemia is an early phase of acute myelogenous leukemia.
Submitting to Autonomy
Authors: David P. Steensma
Journal: Journal of Clinical Oncology (2000)

Article Tools THE ART OF ONCOLOGY: WHEN THE TUMOR IS NOT THE TARGET Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.21.3736 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11054449 Submitting to Autonomy David P. SteensmaxDavid P. SteensmaSearch for articles by this author Show More From the Mayo Clinic, Rochester, MN. https://doi.org/10.1200/JCO.2000.18.21.3736 Full Text PDF Figures and Tables "Submitting to Autonomy." Journal of Clinical Oncology, 18(21), pp. 3736–3737© 2000 by American Society of Clinical Oncology
Erratum
Journal: BMJ (1892)

unexploded powder would most probably be embedded in the surround- ing tissues.If the pistol were a No. 1 saloon pistol, with the cartridge prepared for indoor practice, with only a detonator for firing it, it is possible.The edges of the wound would probably not be scorched, and certainly would not be blackened by powder.The question is Imperfectly put.As shown above, there are three sizes of saloon pistols as regards calibre in ordinary use, and according to the size of calibre so will be the kind and amount of charge and size of bullet.It is not stated in the question whether the pistol was loaded with a bullet or not, but in the reply it is taken for granted that it was so loaded, as the occurrence of a wound is mentioned.A wound, however, might occur under the circumstances named even if the pistol did not have a bullet in it.
Pulmonary Hypertension
Authors: Lester M. Crawford, Jr
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ATLANTIC DIP: Pregnancy outcome for women with pre-gestational diabetes along the Irish Atlantic seaboard.
Authors: F. P Dunne, G. Avalos, M. Durkan, Y. Mitchell, T. Gallacher, M. Keenan, M. Hogan, L. A Carmody, G. Gaffney
Journal: Diabetes Care (2009)

OBJECTIVEProspective evaluation of pregnancy outcomes in pregestational diabetes along the Atlantic seaboard 2006–2007.
Postmarketing drug surveillance
Authors: E. K. Borden
Journal: JAMA (1984)

<h3>In Reply.—</h3> We agree with the views of Dr Borden and colleagues regarding the role of spontaneous reporting in a multicomponent postmarketing surveillance system. Moreover, we share, in large measure, their perception of the purpose of systematic surveillance. Nevertheless, we would like to take this opportunity to comment further on the purpose of our article, to discuss briefly another finding resulting from our examination of phase IV studies that is pertinent to their comments, and to add a word of caution concerning the utility of postmarketing surveillance to quantify beneficial drug effects. While our article focused on new adverse drug reaction discovery as it relates to the phase IV studies we examined, we did not intend to suggest that the detection of unusual or unexpected adversity alone might be a sufficient reason for conducting systematic postmarketing surveillance. It did seem important, however, to convey a message of fact and encouragement
The Scientific Program
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P04.06 The incidence and impact of post-operative stroke in surgery for LGG
Authors: A berger, G Tzarfati, M Costa, M Serafimova, A Korn, T Alfasi, A Kashinian, Z Ram, R Grossman
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND: INTRODUCTION Postoperative neurological deficits may outweigh the benefit conferred by maximal resection of gliomas. Ischemic complications are a common cause of such deficits. In this study, we evaluated the incidence of ischemic events in patients undergoing surgery for low-grade gliomas (LGG) and the long-term neurological and cognitive implications of those events. METHODS Between 2013–2017, 168 patients underwent surgical resection or biopsy for LGG at our center. A full dataset, including pre- and postoperative magnetic resonance imaging (MRI) and long-term clinical evaluation findings, was available in 82 patients that underwent resection, and they comprised our study cohort. We retrospectively analyzed pre- and postoperative demographic, clinical, radiological, anesthetic, and intraoperative neurophysiology data to characterize associated ischemic complications. Overall and progression-free survival, as well as functional and neurocognitive outcomes were evaluated as well. RESULTS The immediate postoperative MRI showed evidence of an acute ischemic stroke adjacent to the tumor resection cavity in 19 patients (23%), 13 of whom developed new neurological deficits as a result of the ischemic event. Infarcts were more common in patients undergoing surgery for a recurrent tumor, especially those involving the Sylvian fissure (p&lt;0.05). Surgery for insular gliomas had the strongest association with postoperative infarcts (multivariate analysis: odds ratio =12.4, 95% confidence interval 2.21–69.8). There was no difference in survival between patients with or without a postoperative infarct. The median Karnofsky Performance Status was lower for the infarct group compared to the non-infarct group at 3 months after surgery (p=0.016), with a gradual significant improvement for the former over one year of follow-up (p=0.04). Immediately after surgery, 27% of the patients without infarcts and 58% of those with infarcts experienced a new motor deficit (p=0.037), decreasing to 16% (p=0.028) and 37% (p=0.001), respectively, at one year. Neurocognitive analysis findings before and 3 months after surgery were unchanged, but there was a significant decrease in naming in patients who experienced an infarct (NeuroTrax computerized battery score of 100±9 and 83±19, p=0.04 respectively). Confusion during awake craniotomy was a strong predictor of the occurrence of an ischemic stroke. CONCLUSIONS Intraoperative strokes are more prevalent among patients who undergo recurrent surgeries, especially procedures in the insula. Although they do not affect survival, these strokes negatively affect the patients’ activity and performance status, especially during the first 3 postoperative months, with gradual functional improvement over one year.
Some little-known classics of old-age medicine
Authors: F. D. Zeman
Journal: JAMA (1967)

These familiar words of the psalmist we usually regard in a figurative way, but they assume far greater significance if taken literally. The author definitely expressed the plaint of the older person in a nomadic culture who, when he was no longer useful, was certain to be left behind to die in solitary agony. Only with the growth of villages and planned agriculture, resulting in an adequate food supply, did it become possible to develop the compassionate protective attitudes of the Judeo-Christian ethic. Every generation of physicians has met, to the best of its limited understanding, the problems of increasing years and their associated disabilities. I would like to discuss a few of the littleknown classic works on old age medicine. <h3>Gabriele Zerbi (1468-1505).—</h3> More than 20 years ago I encountered a reference to the<i>Gerontocomia</i>of Zerbi, a fascinating volume on the care of the aged, written by a
Tumor immunology. Clinical aspects
Authors: C. H. Kirkpatrick
Journal: JAMA (1982)

THE RESULTS of experiments in laboratory animals clearly demonstrate that tumor tissues transplanted between rodents possessing identical histocompatibility antigens can lead to immunologic rejection of the tumor. This has led many investigators to propose that tumors, including spontaneously occurring tumors in man, must result, at least in part, from failure of the immune response of the host to recognize and subsequently destroy cells bearing tumor antigens. This concept of immune surveillance has been invoked as a major mechanism for eradication of spontaneously arising tumor cells in otherwise normal persons, and as an explanation for the exceptionally high incidence of tumors in patients with immune deficiency syndromes and recipients of immunosuppressive therapy. In applying the hypothesis that arose from observations in animal systems to the cancers that afflict man, the following points must be kept in mind. In most experiments, it has been necessary to sensitize the recipient animals with dead
A Handbook on Antiseptics.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Kidney
Authors: Nadine Bazilinski
Journal: JAMA (1991)

Nephrology has come a long way since the first edition of<i>The Kidney</i>. As Drs Brenner and Rector note in their preface, this discipline is steadily evolving through advances in molecular cell biology and recombinant DNA technology. By way of molecular cloning procedures, we now prescribe erythropoietin routinely and use atrial natriuretic hormone and endothelin for research. Substantial progress has expanded our knowledge of the role of cellular proteins and their biochemical functions. We have a better understanding of the electrochemical basis of ion transport and a clearer picture of the immunology of disease and organ reaction. We have advanced in our understanding of the physicochemical principles of dialysis. Our technology for renal imaging has improved and renal therapeutics has expanded, most notably with an explosion of new antihypertensives. New drugs prevent transplant rejection and suppress renal osteodystrophy; others may prevent the relentless progression to chronic renal failure. Myriad recent
Distribution of Pesticides and Polycyclic Aromatic Hydrocarbons in House Dust as a Function of Particle Size
Authors: Robert G. Lewis, Christopher R. Fortune, Robert D. Willis, David E. Camann, Jeffrey T. Antley
Journal: Environmental Health Perspectives (1999)

House dust is a repository for environmental pollutants that may accumulate indoors from both internal and external sources over long periods of time. Dust and tracked-in soil accumulate most efficiently in carpets, and the pollutants associated with dust and soil may present an exposure risk to infants and toddlers, who spend significant portions of their time in contact with or in close proximity to the floor and who engage in frequent mouthing activities. The availability of carpet dust for exposure by transfer to the skin or by suspension into the air depends on particle size. In this study, a large sample of residential house dust was obtained from a commercial cleaning service whose clients were homeowners residing in the Raleigh-Durham-Chapel Hill (Research Triangle) area of North Carolina. The composite dust was separated into seven size fractions ranging from < 4 to 500 microm in diameter, and each fraction was analyzed for 28 pesticides and 10 polycyclic aromatic hydrocarbons (PAHs). Over 20% of the fractionated dust sample consisted of particles < 25 microm in diameter. Fourteen pesticides and all 10 of the target PAHs were detected in one or more of the seven size-fractionated samples. Sample concentrations reported range from 0.02 to 22 microg/g; the synthetic pyrethroids cis- and trans-permethrin were the most abundant pesticide residue. The concentrations of nearly all of the target analytes increased gradually with decreasing particle size for the larger particles, then increased dramatically for the two smallest particle sizes (4-25 microm and < 4 microm).
Nosocomial<i>Burkholderia cepacia</i>Infection and Colonization Associated With Intrinsically Contaminated Mouthwash—Arizona, 1998
Journal: JAMA (1999)

During August 1996-June 1998, 74 patients at two hospitals in Arizona had cultures positive for Burkholderia cepacia. Most isolates were from the respiratory tracts of patients in intensive-care units (ICUs). Because of the large number of B. cepacia isolates, personnel at both hospitals requested the Arizona Department of Health Services assist in an investigation. This report summarizes the results of the investigation.
Hemodialysis: Who and Where
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outbreak of Bacterial Conjunctivitis at a College—New Hampshire, January-March, 2002
Journal: JAMA (2002)

During February 1-14, 2002, approximately 100 students presented to a New Hampshire college's student health service with clinical signs of conjunctivitis (Figure 1). The cause of conjunctivitis was initially thought to be viral. However, because of the high number of cases, eye cultures were collected from 12 consecutive students; Streptococcus pneumoniae was isolated from cultures of all 12 students. The medical director of the student health service notified the New Hampshire Department of Health and Human Services about the outbreak and on February 22, the state health department requested assistance from CDC. This report summarizes preliminary results of the investigation of this outbreak, which indicate that an uncommon strain of pneumococcus caused this outbreak and that health-care providers should consider pneumococcus as a cause of conjunctivitis among college students.