tbuckley/cabot-search huggingface dataset:
Abstract 11831: Late Outcome of Percutaneous Mitral Commissurotomy: Randomized Comparison of Inoue versus Double-Balloon Technique
Authors: Sahmin Lee, Duk-Hyun Kang, Dae-Hee Kim, Jong-Min Song, Kee-Joon Choi, Joo-Hee Zo, Jae-Kwan Song, Seong-Wook Park, Seung-Jung Park
Journal: Circulation (2015)

Introduction: Percutaneous mitral commissurotomy (PMC) using either the Inoue or the double balloon technique showed similar, excellent 7-year outcomes, but very late results after successful PMC have been unknown. Hypothesis: We assessed late results of PMC up to 20 years in a randomized trial comparing Inoue versus double-balloon technique. Methods: Between 1989 and 1995, a total of 302 patients (77 men, 41±11 years) with severe mitral stenosis were randomly assigned to undergo PMC using Inoue (n=152; group I) or double-balloon technique (n=150; group D). The end points were the composite clinical events of death, mitral surgery, repeat PMC, or deterioration of NYHA class ≥3 that occurred after enrollment. Results: The successful immediate results [post-PMC mitral valve area (MVA) ≥1.5 cm 2 and mitral regurgitation (MR) grade ≤2] were achieved in 127 (84%) patients of group I and 122 (81%) patients of group D (p= NS). During median follow-up of 20.7 years (IQR, 18.9 to 22.9), clinical events occurred in 82 (53.9%) patients of group I (37 deaths, 44 mitral surgeries, 9 repeat PMCs and 3 NYHA class ≥3) and 79 (52.7%) patients of group I (34 deaths, 51 mitral surgeries, 5 repeat PMCs and 4 NYHA class ≥3). The event-free survival rates were not significantly different between group I and group D (49.3% and 55.3% at 20 years, respectively; HR, 1.22; 95% CI, 0.88-1.70; p=0.23) (Figure). On multivariate Cox analysis, absence of commissural MR (HR, 1.75; 95% CI, 1.22-2.51; p=0.002), immediate post-PMC MVA &lt;1.8cm 2 (HR, 1.54; 95% CI, 1.04-2.27; p=0.03), and atrial fibrillation (HR, 1.53; 95% CI, 1.04-2.23; p=0.03) were independently related with clinical events after successful PMC. Conclusions: In this randomized trial, the Inoue and double-balloon methods showed similar, good outcomes up to 20 years, and the achievement of effective commissurotomy with development of commissural MR or immediate post-PMC MVA ≥1.8cm 2 is important in optimizing the late results of PMC.
ASH 2010 meeting report—Top 10 clinically‐oriented abstracts in myelodysplastic syndromes (MDS)
Authors: David P. Steensma
Journal: American Journal of Hematology (2011)

Abstract The December 2010 American Society of Hematology (ASH) annual meeting in Orlando, Florida included more than 150 abstracts in the myelodysplastic syndromes (MDS) category. Thirty‐six MDS‐focused abstracts were presented in 6 oral sessions, and 120 additional abstracts were presented in 3 poster sessions. Although the 2010 ASH annual meeting included relatively little new MDS clinical trial data, with only one large randomized trial presented (the Intergroup E1905 study), it was an exciting conference from the standpoint of molecular discoveries in myeloid neoplasms, as various investigative groups presented results offering novel insights into MDS pathobiology, generated via high‐throughput genomic sequencing and other innovative laboratory techniques. Here I summarize and discuss 10 MDS‐related abstracts of special interest, which contain information that informs clinical practice. All 10 of these abstracts are published in full in the November 19, 2010 issue of Blood (volume 116, issue 21) and are identified here by their abstract number and title.
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action
Authors: Juan C. Molero, Thomas E. Jensen, Phil C. Withers, Michelle Couzens, Herbert Herzog, Christine B.F. Thien, Wallace Y. Langdon, Ken Walder, Maria A. Murphy, David D.L. Bowtell, Edna Hardeman, Majid Ghoddusi, David E. James, Gregory J. Cooney
Journal: Journal of Clinical Investigation (2005)
Jewish Medicine
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tolerance to Large Weekly Doses of Primaquine and Amodiaquine in Primaquine-Sensitive and Nonsensitive Subjects
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Engineering and Operating Approaches for Controlling Asbestos Fibers in Drinking Water
Authors: Gary S. Logsdon
Journal: Environmental Health Perspectives (1983)

Techniques are available to minimize the concentration of asbestos fibers in drinking water. Filtration research conducted at locations on Lake Superior and in the Cascade Mountains in Washington has shown that amphibole and chrysotile fibers can be removed by granular media filtration. Removal percentages can exceed 99% when the raw water is coagulated properly and the filtered water turbidity is 0.10 ntu (nephelometric turbidity units) or lower. Filtered water fiber counts below detectable limits of 0.1 to 0.01 X 10(6) fibers/L can be attained. A study by the Metropolitan Water District of Southern California showed that when raw water chrysotile counts ranged from 200 X 10(6) fibers/L to 2000 X 10(6) fibers/L, filtered water fiber counts frequently exceeded 1 X 10(6) fibers/L. Even so, striving to attain a filtered water turbidity of 0.1 ntu resulted in improved fiber removal. Pilot scale and distribution system research projects have shown that asbestos cement (AC) pipes can be protected from dissolution and leaching effects that can result in release of asbestos fibers into drinking water. Suggested techniques include modifying low pH, low alkalinity waters so they are not aggressive; coating the pipe wall with a chemical precipitate; and applying a cement mortar lining to the pipe wall. Operation and maintenance practices related to the distribution system, when AC water mains are in service, can influence the fiber count in tapwater. Main flushing can stir up sediment that accumulates in low-flow and dead-end areas, raising the fiber count. If mains are tapped and the cuttings are not flushed away through the tapping machine, but are instead permitted to fall into the water main, the fiber count can be raised.
Thyroid Cancer in Japan
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevation of Plasminogen Linked to Atherogenesis?
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doxorubicin Cardiotoxicity
Authors: Michael A. Friedman
Journal: JAMA (1978)

Doxorubicin, whose dose-limiting toxicity is cardiomyopathy, was given to four cancer patients. Endomyocardial biopsy specimens and test results of cardiac function were obtained before, during, and after treatment. The biopsy specimens were examined by light and electron microscopy and were graded blindly. Evidence of specific doxorubicin injury was found in 3/4 patients with as little as 180 mg/sq m of the drug and became progressively more severe with higher doses. All test results of cardiac function, including systolic time intervals, remained normal. These data suggest that a specific, progressive subclinical injury to the heart occurs with doxorubicin therapy, which cannot be reliably detected by routine tests. This potential risk must be taken into account with the use of doxorubicin, especially when combined with synergistic agents. (<i>JAMA</i>240:1603-1606, 1978)
Tropical Fish Aquariums
Authors: Robert M. Adams
Journal: JAMA (1970)

Tropical fish aquariums are a possible, though uncommon, source for<i>Mycobacterium marinum</i>skin infections, which may assume the morphological pattern of sporotrichosis. We have observed three of six patients with this condition during the past two years. Shortly before onset, each patient experienced a minor abrasion on the hand, after which he cleaned an aquarium where many of the fish had recently died. Smear cultures of material obtained from the lesions revealed atypical acid-fast organisms, and in each case<i>M marinum</i>was identified. A smear culture from the fish tank of one patient showed<i>M marinum</i>, and acid-fast organisms were observed in the material we obtained from the tubing of the tank of another patient.
Tourette's syndrome hypothesis creates controversy among geneticists
Authors: B. Merz
Journal: JAMA (1988)

COULD A SINGLE GENE be responsible for a panoply of behavioral disorders ranging from Tourette's syndrome (TS) to attention deficit disorder to compulsive eating? The question, posed at the annual meeting of the American Society for Human Genetics in New Orleans, has not only fueled a year-old controversy over the nature of the putative TS gene, it may also rekindle the long-standing debate over the validity of the genetic interpretation of family data dealing with human behavior. The question was raised by society president David E. Comings, MD, City of Hope Hospital, Duarte, Calif. In a departure from the standard presidential address, Comings made a case for his revolutionary theory. He postulated that patients with TS often have not only the motor and vocal tics characteristic of the disorder but a number of other behavior disorders because all of the disorders are governed by one gene. Comings also challenged another
Adrenalectomy permits a late, local TNF-α release in LPS-challenged rat airways
Authors: A. Miller-Larsson, A. Runström, R. Brattsand
Journal: European Respiratory Journal (1999)

The aim of this study was to investigate the variation of intercellular adhesion molecule (ICAM)-1 which occurs between individual airway epithelial cells of distinct phenotype. 16HBE14o- (16HBE) and BEAS-2B cell lines and human airway explants were cultured with medium alone or a mixture of tumour necrosis factor (TNF)-alpha (10 ng x mL(-1)) and interferon (IFN)-gamma (40 ng x mL(-1)) before being immunogold-labelled and examined quantitatively using sensitive high-resolution electron microscopic techniques. By enzyme-linked immunosorbent assay there was a 1.6-fold increase of ICAM-1 in the BEAS-2B cells following the cytokine mix which was not apparent in the 16HBE cells. However, high-resolution scanning electron microscopy demonstrated that an upregulation had occurred; median and ranges for gold particle number per 10 microm2 cell surface were: 7.9 (0-40) for nonstimulated and 19.1 (0-60 for stimulated) (p&lt;0.01, Mann-Whitney U-test). The value for the nonstimulated BEAS-2B cells was 24.2 (0-60), 3-times higher that the constitutive expression in the 16HBE cells (p&lt;0.01), whereas following stimulation, it was 68.5 (20-130) (p&lt;0.01). Values for explant epithelial outgrowths were similar to the 16HBE cells. Immunohistochemistry of the explanted mucosa showed both constitutive and upregulated expression of epithelial ICAM-1 associated with basal and indeterminate cells rather than with ciliated or goblet cells. These results using high-resolution techniques indicate that there is marked cell-to-cell variation in cellular adhesion molecule expression and that it is the basal cells and less well differentiated (indeterminate) epithelial cells which are likely to play key roles in leukocyte retention via intercellular adhesion molecule-1.
Radiology, Detroit
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Epilepsy
Authors: Charles R. Loar
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The discussion of abdominal epilepsy by Peppercorn and associates served to remind us that CNS diseases can cause severe paroxysmal abdominal pains and should be included in the differential diagnosis for such symptoms. I would remind readers, however, that symptom complexes similar to those observed with the authors' patients can be seen in acute intermittent porphyria. In such cases most of the common anticonvulsant drugs, including phenytoin (Dilantin), barbiturates, methsuximide (Celotin), mephenytoin (Mesantoin), and phensuximide (Milontin), are contraindicated because of their ability to precipitate an acute attack.<sup>1</sup> For this reason it seems prudent to determine the level of urinary excretion of δ-aminolevulinic acid and porphobilinogens in patients thought to have abdominal epilepsy before beginning drug therapy.
Medical school curriculum in the People's Republic of China. Progress report after 4 1/2 years of experience
Authors: G. E. Dimond
Journal: JAMA (1976)

FOUR and one-half years ago, I was in the People's Republic of China during the week the medical schools first opened after their five-year suspension of enrollment that was associated with the Cultural Revolution. I reported inThe Journalthat experience and the details of the new three-year medical school curriculum.<sup>1</sup>I further elaborated on my observations in 1975.<sup>2</sup> In February 1976, during a fourth visit, I again saw several faculties and individuals that I first met 4 1/2 years earlier. This offered me an index of change, continuity, and results. The nature of this last visit, escorting 32 students and faculty members from the University of Missouri-Kansas City School of Medicine, facilitated the meeting of Chinese counterparts and the exchange of information. Briefly, an untried educational concept, and frequently with apprehensive faculty participation, has now become institutionalized. The fifth medical school class was enrolled last September. The
Chemodectomas of the carotid body and glomus tympanicum. Sequential occurrence in sisters
Authors: F. E. Schmidt
Journal: JAMA (1978)

CHEMODECTOMA of the carotid body is uncommon; fewer than 550 cases have been reported. A familial tendency toward development of chemodectomas in the contralateral carotid body or in other sites where chemoreceptor tissue is found has been documented. This familial occurrence and the tendency of chemodectomas of the carotid body to be bilateral or multiple when patients have relatives with chemodectomas deserve emphasis. We have treated two sisters for tumors of the glomus tympanicum who returned several years later with carotid body tumors. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 47-year-old woman noted a sense of fullness in her left ear in 1960. She was examined in South Carolina, and a tumor of the glomus tympanicum was located and excised. She underwent three subsequent excisions and was seen by one of us (M.L.L.) in 1969; an excision of a recurrent tumor of the glomus tympanicum was performed. Six months later she
Even air in the home is not entirely free of potential pollutants
Authors: A. Skolnick
Journal: JAMA (1989)

A 10-YEAR study by the US Environmental Protection Agency (EPA), Washington, DC, shows that, for some pollutants, the air outside may be safer to breathe than air in the home. Speaking at the American Lung Association's second annual Science Writers' Forum in Annapolis, Md, Lance A. Wallace, PhD, an environmental scientist at the EPA, said that most exposure to a number of known or suspected carcinogens appears to come primarily from personal activities rather than from industrial sources. This is true, he says, even in the country's most concentrated chemical manufacturing areas. <h3>Daily Dangers</h3> The risks Americans may face from some of the pollutants dumped and leaked into the environment by industry may be less than the risks from activities in the home such as smoking, showering, using room deodorizers, and storing and wearing dry-cleaned clothing, Wallace says. Quoting the comic strip "Pogo," he says, "We have met the enemy
SYPHILIS IN ANTHROPOIDS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diet and serum potassium in patients on ACE inhibitors
Authors: C. B. Good
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Angiotensin-converting enzyme (ACE) inhibitors, widely prescribed for the treatment of hypertension, have become a mainstay in the treatment of congestive heart failure. These agents may increase serum potassium, with an incidence of 1% to 2.2% in patients treated for hypertension, and 3.5% to 4.8% in patients treated for congestive heart failure.<sup>1</sup>Advanced renal disease, diabetic nephropathy, potassium supplementation, and potassium-sparing diuretics all increase the risk of hyperkalemia in patients taking ACE inhibitors.<sup>2,3</sup>Many patients with cardiac conditions or elevated blood pressure are counseled to use salt substitutes and to increase their oral potassium intake by ingestion of potassium supplements or foods rich in potassium. Patients may not realize that potassium supplementation can be problematic when taking ACE inhibitors, and physicians may not be aware that their patients are receiving additional potassium, either through diet or supplementation. We surveyed patients taking ACE inhibitors found to have