tbuckley/cabot-search huggingface dataset:
Concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) for newly diagnosed glioblastoma multiforme (GBM). Conclusive results of a randomized phase III trial by the EORTC Brain & RT Groups and NCIC Clinical Trials Group
Authors: R. Stupp, W. P. Mason, M. J. Van Den Bent, M. Weller, B. Fisher, M. Taphoorn, A. A. Brandes, G. Cairncross, D. Lacombe, R. O. Mirimanoff
Journal: Journal of Clinical Oncology (2004)

2 Background: Standard therapy of GBM after biopsy or resection is RT. TMZ, a novel methylating agent demonstrated some activity against recurrent glioma. In a phase II trial we observed a potential survival advantage by adding TMZ concomitantly and adjuvant to RT (Stupp et al. JCO 2002). In this randomized trial we tested this novel regimen against RT. Methods: Patients (pts) age 18–70 years with histologically proven newly diagnosed GBM (WHO grade IV) were eligible. Pts were randomized between standard RT (60 Gy in 30 daily fractions of 2 Gy) versus the same RT and concomitant (TMZ 75 mg/m2/d, daily up to 42 days) followed by up to 6 cycles of adjuvant TMZ (150–200 mg/m2, daily x 5d, q28 d). Survival (intent to treat) was the primary endpoint aiming at a 30% improvement (log-rank). Pathology was centrally reviewed. Results: Five hundred and seventy-three pts from 85 centers were randomized. Median follow-up is 2 years, 436 patients have died. Median time between histological diagnosis and treatment start was 5 weeks. RT was delivered as prescribed in 93% of pts. Concomitant TMZ was administered without interruption in 76%, temporarily interrupted in 11% and prematurely discontinued in 12%. Adjuvant TMZ was given to 76% of pts, 36% completed all 6 cycles for a total of 924 cycles. The increase in median survival is 3 months. The log-rank test is significant with a p-value of < .0001. The hazard ratio is 0.62 (95% c.i. 0.51–0.75). Grade 3/4 hematotoxicity was observed in 7% of pts during concomitant TMZ/RT treatment, and in 16% (5.2% of cycles) of the adjuvant TMZ. Patients continue to be followed to evaluate long term effects of treatment. Conclusions: Concomitant and adjuvant TMZ chemotherapy significantly improves PFS and overall survival in GBM pts. This treatment is safe and well tolerated. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Schering-Plough; Schering-Plough Research Institute Schering-Plough Schering-Plough Research Institute Schering-Plough Research Institute
SP0165 NEW TRENDS IN BIOMARKERS IN INFLAMMATORY JOINT DISEASE
Authors: Eugen Feist
Journal: Annals of the Rheumatic Diseases (2019)

<h3></h3> This lecture provides an overview on new developments in biomarker research and standardization in inflammatory joint diseases. The presentation includes an introduction of established and new biomarkers in serum and synovial fluid as well as methods for their detection. Furthermore, an overview on different modifications of auto-antigens (including citrullinated, carbamylated and acetylated isoforms) and their role in immune response and pathogenesis of disease will be given. The diagnostic performance of new and established biomarkers will be discussed including antibodies against modified antigens also illustrated by difficult to diagnose cases. In this context, special attention will be attributed to the predictive value of biomarkers for diagnosis of disease and treatment response. <h3>Disclosure of Interests:</h3> Eugen Feist Grant/research support from: Pfizer, Roche, Novartis, BMS, Sanofi, Lilly, Consultant for: Pfizer, Roche, Novartis, BMS, Abbvie, Celgene, Sanofi, MSD, Lilly, Speakers bureau: Pfizer, Roche, Novartis, BMS, Abbvie, Celgene, Sanofi, Lilly
Stab Wounds Associated With Terrorist Activities in Israel
Authors: Steve Sosebee
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The article by Dr Hanoch and colleagues<sup>1</sup>went beyond mere medical issues into politics. As one who locates medical care for injured children in Lebanon, the West Bank, and Gaza Strip, I can say that this article was both unfair and inaccurate. After all, what is "terrorism"? Attacking an armed soldier on patrol in a village under military occupation is both legal under international law and a method used by our forefathers in our liberation struggle. I hate violence, but hate even more the oppressive systems that force people to take up arms for freedom. In addition to the jaded manner in which you allowed the struggle for national and political rights to be categorized in Palestine, there is also a question of balance. Between 1987 and 1994, more than 90 000 Palestinian civilians were injured by gunfire, beatings, or bombings in the West Bank and
Reporting of AIDS: tracking HIV morbidity and mortality
Authors: J. W. Buehler
Journal: JAMA (1989)

Physicians and other health care providers have reported more than 110 000 cases of the acquired immunodeficiency syndrome (AIDS) to local and state health departments in the United States since 1981, including 34 000 in the past 12 months alone. Surveillance of AIDS in the United States accounts for nearly 60% of cases reported to the World Health Organization by 152 nations,<sup>1</sup>reflecting both the extent of the human immunodeficiency virus (HIV) epidemic in this country and the completeness of our reporting compared with that of other nations. Earlier in this decade, reports of AIDS cases in homosexual men, intravenous drug users, their heterosexual partners, transfusion recipients, and infants defined the principal modes of HIV transmission, well in advance of the discovery of HIV. More recently, AIDS surveillance has documented the spread of the epidemic beyond the major coastal centers, the striking disparity in the AIDS burden among blacks
From the Congressional Office of Technology Assessment
Authors: E. J. Power
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Athletic Injuries
Authors: James M. Robey
Journal: JAMA (1971)

The application of epidemiologic methods in determining the nature and extent of athletic injuries occurring in high school football shows that (1) no significant difference in the rate of injury for players based on time exposed to risk exists, (2) injury risk increases with age, (3) a student with a history of prior football injury sustains injury at a significantly higher rate than his associates with no history, and (4) certain types of protective equipment are associated with greater injury incidence. These data are part of a five-year continuing study of athletes in 43 high schools.
Reflections of a maverick measurement maven
Authors: C. H. McGuire
Journal: JAMA (1995)

All living physicians who have ever practiced medicine in the United States share memories of a common ordeal—designed, most of us believe, to protect the public or, as some cynics would have it, to preserve a profitable monopoly—namely, the examination for licensure and/or specialty certification. Herewith, a very personal view of the alleged horrors of"how it used to be" and an account of the changes (progress?) I have witnessed over the past third of a century in the philosophy, procedures, and techniques of assessing physician competence. For editorial comment see p 741. When I entered the field of medical testing 35 years ago, no one had ever heard the word "simulation" applied to examinations in medicine, nor had anyone read a book or seen a test printed in invisible ink. The few existing computers occupied entire floors of large university buildings; litigation against a testing authority for unwelcome results was
Erratum for the Research Article: “Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism” by I. Vujkovic-Cvijin, R. M. Dunham, S. Iwai, M. C. Maher, R. G. Albright, M. J. Broadhurst, R. D. Hernandez, M. M. Lederman, Y. Huang, M. Somsouk, S. G. Deeks, P. W. Hunt, S. V. Lynch, J. M. McCune
Journal: Science Translational Medicine (2017)
DIET, SERUM PROTEINS AND EDEMA
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Religious Healing.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myelodysplastic Syndromes Clinical Practice Guidelines in Oncology
Journal: Journal of the National Comprehensive Cancer Network (2003)

In the general population, myelodysplastic syndromes (MDS) occurs in 5 per 100,000 people. However, among individuals older than age 70, the incidence is between 22 and 45 per 100,000. Managing MDS is complicated by the generally advanced age of the patients (median ages range from 65 to 70 years old), attendant nonhematologic comorbidities, and the older patients' relative inability to tolerate certain intensive forms of therapy. These guidelines extensively evaluate reviewed, risk-based data and indicate useful approaches for managing MDS. For the most recent version of the guidelines, please visit NCCN.org
MEDICINE AND THE EXPERIMENTAL LABORATORY
Journal: JAMA (1933)

A recent contributor<sup>1</sup>to current medical literature has commented on the change that has taken place in diagnosis and therapeutics through the adaptation of chemistry, physics and some of the biologic sciences to clinical needs. During the past two decades, signal advances have been made: in internal medicine through a better understanding of the chemistry of the blood under various conditions, in electrocardiography and physical therapy by the application of newer developments in physics, and in the control of infectious diseases by the use of recent discoveries in bacteriology. The view has frequently been voiced that the obvious tendency to depend increasingly on the laboratory for aid in diagnosis or in following the response to treatment is not particularly encouraging; fear is expressed lest the product of modern training lose the<i>tactus eruditus</i>. To other observers it is plain that the rise of laboratory medicine is part of a
ACNE‐Q
Authors: A.F. Klassen, S. Lipner, M. O'Malley, N.M. Longmire, S.J. Cano, T. Breitkopf, C. Rae, Y.L. Zhang, A.L. Pusic
Journal: British Journal of Dermatology (2019)

痤疮是一种常见的皮肤病,影响很多青少年和成人。这项来自加拿大和美国的研究旨在创建一个称为 ACNE‐Q 的患者报告结局测量工具(即,问卷)。患者报告结局测量工具有很多用途,例如,它们可在治疗前后用于评估患者症状或护理质量的任何改善。 ACNE‐Q 测量与痤疮患者有关的结局。为了制定 ACNE‐Q,作者们访问了 21 名有痤疮和痤疮瘢痕的患者,以确定他们的顾虑。根据此信息,作者们起草了 7 个测量外观(面部、胸部和背部痤疮,痤疮瘢痕和面部皮肤)、症状和外观相关忧虑的量表。 向 10 名患者和 16 名专家出示了这些量表,以确保它们易于理解且涵盖了与大部分患者相关的问题。之后作者们在一个由 256 名痤疮和/或痤疮瘢痕患者组成的样本中检验了 ACNE‐Q。 研究团队发现这 7 个量表表现良好(均可靠且有效)。ACNE‐Q 现在可在研究中用于测量痤疮和/或痤疮瘢痕治疗后外观、症状和忧虑的变化。ACNE‐Q 也可被医务人员和他们的患者用于确定顾虑和共享决策。
Informed consent.
Authors: K C Mohanty
Journal: BMJ (1993)

EDITOR,-D D Kerrigan and colleagues report that giving patients detailed information before hernia repair did not significantly increase their anxiety but say that it would help in subsequent litigation.'Although I accept the philosophy behind their conclusion, elective hernia repair is unlikely to give rise to many cases of litigation.Anxiety may be associated with practically every operation.It is doctors' utmost duty to warn of the most serious and most common complications: the Sidaway case in the English courts is a precedent.2Lord Bridge stated that if a complication occurs in more than 10% of cases the patient must be told.In the case of specific risks, such as death, paralysis, and blindness, the patient must also be told even if the risk is less than 1%.This common law, also quoted by the NHS Management Executive's Guide to Consent for Examination or Treatment,3 is not applicable in Kerrigan and colleagues' study: complications do not occur in more than 10% of patients after elective hernia repair, nor are there specific risks of death, paralysis, or blindness.Thus the choice of this procedure for examining consent is not appropriate.The information sheets given to both groups in the study were inadequate and did not satisfy the Department of Health's guidelines3 as they did not mention possible alternatives to elective hernia repair.Doctors should make their own judgment as to how much information each patient needs.There is no point in loading patients with all possible information available.As long as the doctor has
Giardiasis
Authors: Corrado Minetti, Rachel M Chalmers, Nick J Beeching, Chris Probert, Kenneth Lamden
Journal: BMJ (2016)

Giardia is a leading but treatable cause of infectious gastroenteritis worldwide, with a reported prevalence of 2-7% in high income countries and 2-30% in low income countries. 1 Giardiasis is included in the World Health Organization Neglected Diseases Initiative owing to its burden and association with poverty. 2 Its incidence in the United Kingdom is underestimated because of the lack of diagnostic sensitivity of traditional faecal microscopy 3 and the mistaken belief that it is mostly acquired abroad, so often only people reporting foreign travel are tested.This update discusses the epidemiology, clinical presentation, diagnosis, and management of giardiasis specifically in high income countries. When to consider Giardia?Giardia infections can be asymptomatic (estimated in 5-15% of infected people), 33 but typical symptoms include diarrhoea,
Contents
Authors: Y Hua, A Tai, S Tong, A Lok, L Meredith, H Harris, G Wilson, N Fletch Er, P Balfe, J Mckeat Ing, D Ploen, M Hafirassou, K Himmelsb Ach, D Sauter, M Binioss Ek, T Weiss, T Baumert, C Sch, E Hildt, M Martinot-Peignoux, R Carvalho-Filho, M Lapalus, A Netto-Ca Rdoso, O Lada, R Batrla, F Krause, T Asselah, P Marcellin, F Sanai, D Mousa, A Al-Mdan, G Al-Sho, H Al-Ashga, K Al Meshari, A Al-Qa, M Saadeh, K Bzeizi, H Aleid, J Berenguer, J Alvarez-P Ellicer, A Carrero, M Wichmann, J Lo ´pez- Aldeguer, J Mallolas, M Galindo, E Van, Den Eynde, M Te ´llez, C Quereda, C Tural, J Sanz, C Barros, I Santos, F Pulido, J Guardiola, E Ortega, R Rubio, N Urruna Ga, A Singal, J Cuthbert, D Rockey, M Sørensen, K Mikkels En, K Frisch, G Villad Sen, S Keiding, J Du, Ple Ssis, H Vanheel, C Janssen, L Roos, T Slavik, P Stivak Tas, M Nieuwo Udt, S Van Wyk, W Vieira, E Pretorius, M Beuke, R Farre, J Tack, W Laleman, J Fevery, F Nevens, T Rosk, S Van Der Merwe
Journal: Journal of Hepatology (2013)
Pseudochylothorax in pleural effusion due to coronary artery bypass surgery
Authors: E. Garcia-Pachon, L.C. Fernandez, F. Lopez-Azorin, I Padilla-Navas
Journal: European Respiratory Journal (1999)

This report describes a patient with chylous pleural and pericardial effusions in conjunction with severe lymphoedema resembling elephantiasis. The chylous effusions and generalized lymphoedema were associated with a signet-ring cell carcinoma.
Evolution and the cardiac patient
Authors: P. HARRIS
Journal: Cardiovascular Research (1983)

Journal Article Evolution and the cardiac patient Get access PETER HARRIS PETER HARRIS From the Department of Cardiac Medicine, Cardiothoracic Institute, 2 Beaumont Street, W1N2DX Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 17, Issue 6, June 1983, Pages 313–319, https://doi.org/10.1093/cvr/17.6.313 Published: 01 June 1983
Film Reviews
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New concepts in hypertrophic obstructive cardiomyopathy I
Authors: P. M. Shah
Journal: JAMA (1979)

HYPERTROPHIC obstructive cardiomyopathy is a form of primary myocardial disease with a characteristic clinical and pathological expression. The disorder is referred to by several names. Braunwald and associates<sup>1</sup>introduced and popularized the term "idiopathic hypertrophic subaortic stenosis" in the United States, Wigle and associates<sup>2</sup>coined the term "muscular subaortic stenosis" in Canada, while in Europe it is generally referred to as hypertrophic obstructive cardiomyopathy (HOCM), following the lead of Goodwin and associates<sup>3</sup>at the Royal Postgraduate School of Medicine in London. A term that includes subaortic stenosis is unfortunate, since the disorder may be expressed without left ventricular outflow obstruction and since patients have been described as having isolated infundibular subpulmonic stenosis. It is more accurate and potentially less confusing to refer to the disorder as hypertrophic cardiomyopathy and add the word "obstructive" if either left or right ventricular outflow obstruction can be demonstrated.<sup>4</sup>The historical aspects of
CURRENT MEDICAL TERMINOLOGY: 1964 EDITION
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intestinal metabolism.
Authors: J W Porteous
Journal: Environmental Health Perspectives (1979)

The anatomy of the intestine is outlined. The kinetics of cell proliferation, differentiation, and migration in intestinal epithelium are described. The distribution of cell types between the proliferation and differentiation compartments of the epithelium is summarized. Seven preparations of intestine in current use for metabolic studies are listed. An outline review is presented of recent results on glucose, amino acid and ketone body metabolism obtained with three of these preparations: the ligature-isolated loop of intestine in vivo; the vascularly and luminally perfused intestine in vitro; and suspensions of respiring intestinal epithelial cells in vitro. Reasons are given for thinking that these experimental systems are among the most useful currently available for metabolic studies, perhaps especially in the investigation of the metabolic fate of potentially toxic materials to which animal species may be exposed.