tbuckley/cabot-search huggingface dataset:
Risk factors for ectopic pregnancy. A population-based study
Authors: P. A. Marchbanks
Journal: JAMA (1988)

To evaluate the association between ectopic pregnancy and 22 potential risk factors, we conducted a population-based case-control study. The investigation included 274 cases diagnosed from 1935 through 1982 in residents of Rochester, Minn, and 548 matched controls selected from live-birth deliveries. Risk factor information documented prior to the last index menstrual period was obtained via medical record abstract. Univariate matched analyses revealed nine variables associated with a significantly elevated relative risk of ectopic pregnancy. Following conditional logistic regression, four variables remained as strong and independent risk factors for ectopic pregnancy: current intrauterine device use (relative risk, 13.7; 95% confidence interval, 1.6 to 120.6), a history of infertility (relative risk, 2.6; 95% confidence interval, 1.6 to 4.2), a history of pelvic inflammatory disease (relative risk, 3.3; 95% confidence interval, 1.6 to 6.6), and prior tubal surgery (relative risk, 4.5; 95% confidence interval, 1.5 to 13.9). Theoretically, any condition that prevents or retards migration of the fertilized ovum to the uterus could predispose a woman to ectopic gestation. Further research is needed to clarify the impact of other potential risk factors in the etiology of ectopic pregnancy. (<i>JAMA</i>1988;259:1823-1827)
Schizophrenia
Authors: J M Kane
Journal: New England Journal of Medicine (1996)

Schizophrenia is an often severe and disabling disorder that usually begins in late adolescence or early adulthood. The essential features of this illness are a variable array of symptoms, such as delusions, hallucinations, disorganized or impoverished speech or behavior, flattened affect, and avolition. The onset may be abrupt or insidious; in most instances, however, there is a prodromal phase characterized by gradual social withdrawal, diminished interest in or functioning at school or work, changes in appearance and hygiene, or behavior that is odd or unusual for the person. Although a diagnosis of schizophrenia cannot be made on the basis of . . .
Update: Influenza Activity—Woldwide, 1995
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WHERE RECIPROCITY SHOULD NOT APPLY.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Modern Hospital.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
250 Left Ventricular Punctures Without Accident
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MORGAGNI (1682-1771)
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acquired Immunodeficiency Syndrome and the Nervous System
Authors: Pietro Cocchi
Journal: JAMA (1990)

<h3>To the Editor.—</h3> As reported by Dalakas and colleagues,<sup>1</sup>human immunodeficiency virus (HIV) is not only lymphotropic but also neurotropic and can invade the central and peripheral nervous systems early, resulting in a latent or overt infection. The neurotropism of HIV should not be entirely surprising if this retrovirus is to be considered a human representative of the lentivirus subfamily. The primary neuropathy, which seems to be a direct result of HIV infection of the central nervous system (CNS), has important pathological and clinical implications. In adults, neurological symptoms may sometimes be the sole manifestations of acquired immunodeficiency syndrome.<sup>2</sup>In pediatric patients, the CNS is often the primary site of HIV infection rather than the immune system, and the neuropathy may progress even with minimal immunologic abnormalities,<sup>3</sup>indicating that neural tissue is a principal target of the retrovirus. In infants and children we have observed intellectual
Abstract 4118: Molecular cytometry for immunotherapy trials
Authors: Woodrow E. Lomas, Aidan F. Winters, Jason Alexandre, Jody Martin, Nidhanjali Bansal, Margaret Nakamoto, Brent Gaylord, Suraj Saksena, Pratip K. Chattopadhyay
Journal: Cancer Research (2019)

Abstract The ability to simultaneously query both protein and mRNA expression on tens of thousands of single cells has emerged only recently, with the development of CITE-seq, REAP-seq, and Ab-seq platforms. Each technology relies on antibodies conjugated to oligonucleotide tags, followed by capture of antibody-stained cells for single cell RNA-sequencing. The technologies have important advantages over flow cytometry, chiefly in that they allow study of a limitless number of parameters, and single cell RNA sequencing, which cannot identify cell populations with as much verity as protein/antibody-based analysis. We characterized the newest molecular cytometry technique (Ab-seq, BD Biosciences) by titrating nearly 100 antibodies (in a single staining experiment and sequencing run), and demonstrated that oligonucleotide antibodies exhibit the same staining characteristics and patterns as flow cytometry antibodies. We also comprehensively examined cells discordant for protein and mRNA expression, in order to discriminate true features of immune cell biology from artifacts caused by drop-out in sequencing assays. Importantly, we also found that mRNA expression could guide the discrimination of cells expressing a protein versus those lacking expression, and define a remarkably low limit of detection for the technology: 1-5 molecules. This remarkable sensitivity will allow detection of cells expressing even the lowest levels of immune exhaustion and checkpoint molecules in cancer immunotherapy trials, and could enable better biomarker discovery than existing technologies. Moreover, this approach allows more detailed characterization of the tumor microenvironment and periphery than ever before. Indeed, in a lymphoma patient, we show that cells expressing both PD1 and CTLA4 carry a unique and specific signature that includes markers never revealed by flow cytometry or other technologies, which might represent new targets for immunotherapy. In sum, this presentation will characterize this new technology and demonstrate the power and promise of new molecular cytometry tools. Citation Format: Woodrow E. Lomas, Aidan F. Winters, Jason Alexandre, Jody Martin, Nidhanjali Bansal, Margaret Nakamoto, Brent Gaylord, Suraj Saksena, Pratip K. Chattopadhyay. Molecular cytometry for immunotherapy trials [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4118.
Chinese heroin.
Authors: M W Carney
Journal: BMJ (1972)

B.M.J. in press) inunosuppression has been managed on the basis of regular white cell counts with acute rejection episodes diagnosed on biochemical and clinical grounds.One patient has died, five nephrectomies have been performed, and the remaining 27 patients (82%) are alive and well at from three years to six months post- transplant.We feel from our research ex- perience that the rosette inhibition test is not sensitive or accurate enough as an index of "immune status" to be used as the basis of patient management in clinical renal transplantation.-Weare, etc.,
The Role of Hypoventilation and Ventilation-Perfusion Redistribution in Oxygen-induced Hypercapnia during Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Authors: TRACEY D. ROBINSON, DAVID B. FREIBERG, JEFF A. REGNIS, IVEN H. YOUNG
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The detailed mechanisms of oxygen-induced hypercapnia were examined in 22 patients during an acute exacerbation of chronic obstructive pulmonary disease. Ventilation, cardiac output, and the distribution of ventilation-perfusion (V˙ a/Q˙ ) ratios were measured using the multiple inert gas elimination technique breathing air and then 100% oxygen through a nose mask. Twelve patients were classified as retainers (R) when PaCO2 rose by more than 3 mm Hg (8.3 ± 5.6; mean ± SD) after breathing 100% oxygen for at least 20 min. The other 10 patients showed a change in PaCO2 of − 1.3 ± 2.2 mm Hg breathing oxygen and were classified as nonretainers (NR). Ventilation fell significantly from 9.0 ± 1.5 to 7.2 ± 1.2 L/min in the R group breathing oxygen (p = 0.007), whereas there was no change in ventilation in the NR group (9.8 ± 1.8 to 9.9 ± 1.8 L/min). The dispersion of V˙ a/Q˙ ratios as measured by log SD of blood flow (log SD Q˙) increased significantly in both R (0.96 ± 0.17 to 1.13 ± 0.17) and NR (0.77 ± 0.20 to 1.04 ± 0.23, p < 0.05) groups breathing oxygen, whereas log SD of ventilation (log SD Q˙ ) increased only in the R group (0.97 ± 0.24 to 1.20 ± 0.46, p < 0.05). This study suggests that an overall reduction in ventilation characterizes oxygen-induced hypercapnia, as an increased dispersion of blood flow from release of hypoxic vasoconstriction occurred to a significant and similar degree in both groups. The significant increase in wasted ventilation (alveolar dead space) in the R group only may be secondary to the higher carbon dioxide tension, perhaps related to bronchodilatation.
10. T-cell Lymphoma/HIV-Lymphoma
Authors: U Tirelli, C Simonelli, E Vaccher, F Martellotta, M Spina, M Michieli, M Rupolo, G Digennaro, L Abbruzzese, M Mazzucato, V Gattei, D Capello, E Berra, M Cerri, C Deambrogi, A Glognini, M Martini, D Rossi, A Conconi, S Franceschetti, L Larocca, A Carbone, G Gaidano, M Franchina, M Karimi, T Watanabe, D Spagnolo, L Abraham
Journal: Annals of Oncology (2005)
Skin immunity
Authors: T. Schwarz
Journal: British Journal of Dermatology (2003)

As the major barrier of the body to the outside, the skin is constantly confronted with microbial, chemical and physical insults. However, the skin does not only function as a mechanical barrier but also uses the immune system for protection. Therefore, the skin is endowed with the capacity to generate immune responses of the innate as well as of the adaptive type.
Tracheobronchomegaly causing recurrent pneumonia
Authors: G. Reisz
Journal: JAMA (1981)

TRACHEOBRONCHOMEGALY (TBM), or Mounier-Kuhn syndrome, is the syndrome of enlarged, collapsible trachea and main bronchi associated with recurrent and chronic respiratory tract infections. Although the pathogenesis is uncertain, TBM is thought to be caused by a congenital weakness of the connective tissue in the large airways.<sup>1-4</sup>We describe a 68-year-old man with TBM and suggest that it be considered in the differential diagnosis of recurrent respiratory tract infection even in an older patient. <h3>Report of a Case</h3> A 68-year-old man with a 20-year history of recurrent pneumonia required three hospitalizations for pneumonia in the year preceding his death. He smoked 30 cigarettes per day for 36 years and had positive results on PPD test, VDRL test for syphilis, and FTA-ABS test. Family history was largely unknown, but his four children were reported to be in good health. Chest roentgenograms on admission showed consolidation in the right lower, middle, and
Pseudo DNA autosensitivity. A factitial disease
Authors: P. C. Anderson
Journal: JAMA (1966)

DEOXYRIBONUCLEIC ACID (DNA) autosensitivity of the type described in 1961 by Levin and Pinkus is a syndrome of two principle parts: (1) recurrent, painful, and ecchymotic nodules and plaques on the extremities, and (2) immediate hypersensitivity to injections of DNA, localized to the skin of the affected areas while the same test on the skin of the flank is nonreactive. Other cases have been reported of this recently described and peculiar syndrome.<sup>2,3</sup>All cases occurred in women, in whom the general health was not affected. Significantly, adequate treatment with chloroquine gave unequivocal relief of symptoms in all these patients. <h3>Report of a Case</h3> Our patient was a 13-year-old girl in whom persistent painful swellings developed on the dorsum of the left hand first in February 1964, after a bump with a piece of stovewood. Impressive ecchymotic nodules progressed steadily up the left arm almost to the shoulder and, about
Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer (mCRPC).
Authors: Gregory Russell Pond, William R. Berry, Matt D. Galsky, Brian A. Wood, Lance Howard Leopold, Guru Sonpavde
Journal: Journal of Clinical Oncology (2012)

51 Background: Data suggest docetaxel clearance is increased in castrate men. An association of docetaxel-induced grade ≥3 neutropenia with overall survival (OS) may provide a rationale for tailored dosing in mCRPC. Methods: The association of cycle 1 neutropenia with OS was examined in a randomized phase II trial of 221 men with mCRPC receiving docetaxel-prednisone combined with placebo or AT-101 (bcl-2 inhibitor), which performed weekly blood cell counts during the first cycle. Patients from both arms were combined as no outcome or neutropenia differences were observed. OS was calculated from randomization by the Kaplan-Meier method and Cox proportional hazards regression models were used to estimate the association with OS. Results: The difference in OS between men with day 8 ≥grade 3 neutropenia and those with ≤grade 2 neutropenia was significant after adjusting for stratification factors (HR: 0.64, p= 0.048). Excluding men with delayed cycle 2 yielded a more significant association of grade 3-4 neutropenia on day 8 with survival (Table). Men with ≥grade 3 neutropenia and ≥30% PSA decline by day 90 had improved OS compared with men exhibiting neither (HR: 0.51, p=0.014). Conclusions: In mCRPC receiving docetaxel, ≥grade 3 neutropenia on day 8 was prognostic for improved OS, suggesting its potential utility as a pharmacodynamic marker in this hypothesis-generating analysis. Since the association was stronger after excluding patients that experienced dose delays, grade 3 neutropenia may confer a more favorable therapeutic index than grade 4 neutropenia. The exploration of dose modulation of docetaxel to attain ≥grade 3 neutropenia on day 8 may be warranted. [Table: see text]
Stat Bite: Smoking Status of U.S. High School Seniors,1976-1993
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Stat Bite : Smoking Status of U.S. High School Seniors,1976–1993 Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 8, 19 April 1995, Page 565, https://doi.org/10.1093/jnci/87.8.565 Published: 19 April 1995
SMOKE.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Instructions for Authors
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Satellite and Commercial Medical Clinics
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal