tbuckley/cabot-search huggingface dataset:
Increased risk of group B streptococcal disease in twins
Authors: M. S. Edwards
Journal: JAMA (1981)

Infants who are the products of multiple births comprise a newly defined group of patients at increased risk for the development of invasive, group B streptococcal infection. This report summarizes the clinical and bacteriologic features of 11 sets of twins and one set of triplets in which one (nine sets) or more (three sets) infants had proved early- or late-onset group B streptococcal infection. Reasons for the enhanced susceptibility of index patients and their siblings are discussed. On the basis of these observations, an empirical approach is proposed for the treatment of the apparently noninvolved sibling of a twin with invasive group B streptococcal infection. (<i>JAMA</i>1981;245:2044-2046)
Interferon‐alpha therapy for chronic myelogenous leukemia during pregnancy
Authors: Mika Kuroiwa, Hisashi Gondo, Kenji Ashida, Tomohiko Kamimura, Toshihiro Miyamoto, Yoshiyuki Niho, Kiyomi Tsukimori, Hitoshi Nakano, Shouichi Ohga
Journal: American Journal of Hematology (1998)
Impact of influenza A in a nursing home
Authors: R. A. Goodman
Journal: JAMA (1982)

Outbreaks of influenza A in the institutionalized elderly have been reported only rarely. Such an outbreak occurred in a nursing home in the period Dec 12, 1980, through Jan 21, 1981. Thirty (25%) of the 120 residents had onset of influenza-like illness during the outbreak. Influenza A/ Bangkok/79-like (H3N2) virus was isolated from throat swab specimens from five of eight acutely ill patients. Thirteen persons were hospitalized; nine persons died (case-fatality ratio, 30%). This outbreak documents that mortality associated with an influenza outbreak can be substantial in a closed population of the elderly. Because nursing home residents are an easily accessible high-risk population, control and prevention of influenza should be a high priority in nursing homes. (<i>JAMA</i>1982;247:1451-1453)
Medical education and the social sciences
Authors: R. J. Bulger
Journal: JAMA (1981)

In this issue ofThe Journal, Petersdorf and Feinstein (p 943), present data relating to the breadth and depth of formal instruction in the medically related social sciences in undergraduate and some postgraduate medical curricula. Although one may not be enamored of the authors' classifications of sociology (ie, "of," "for," "in," "at," "from," and "around" medicine), their contribution is an important one because it illustrates major differences in the acceptance of the processes and products of the social sciences by academically based internists, pediatricians, and family physicians. One is left to guess where the psychiatrists, surgeons, radiologists, and others might stand. Clearly, however, one can conclude that the impact of the social sciences on medical education is still not pervasive even if their influence has increased over the past decade or two. Many medical school faculty have difficulty in understanding behavioral objectives in curriculum design. They do not realize the
Plexitis as a predictive factor of early postoperative clinical recurrence in Crohn's disease
Authors: H Sokol, V Polin, A Lavergne-Slove, Y Panis, X Treton, X Dray, Y Bouhnik, P Valleur, P Marteau
Journal: Gut (2009)

<h3>Background and aims:</h3> A previous study suggested that the presence of myenteric plexitis in the proximal resection margins could be predictive of early endoscopic recurrence after ileocolonic or ileal resection for Crohn's disease (CD). The aim of the present study was to assess the predictive value of plexitis for early clinical CD recurrence. <h3>Methods:</h3> All consecutive patients with ileocolonic or ileal resection for active CD in Lariboisière Hospital (Paris) between 1995 and 2006 were included. Clinical, surgical, histological and follow-up data were extracted from medical charts. Early clinical recurrence was defined as the reappearance of CD clinical manifestations requiring a specific treatment within 2 years postsurgery. The proximal resection margin was analysed using haematein eosin saffron (HES) staining and immunochemistry targeting mastocytes (anti-CD117 antibody) and lymphocytes (anti-CD3 antibody). Eosinophils were detected by HES staining. Ten cases of ileocolonic resections for caecal carcinoma served as controls. <h3>Results:</h3> Data were available from 171 postoperative follow-up periods in 164 patients with CD. Early clinical recurrence of CD occurred in 28.1%. In multivariate analysis, factors associated with postoperative recurrence were active smoking (hazard ratio (HR) = 1.94; 95% CI 1.06 to 3.60; p = 0.033), submucosal plexitis with ⩾3 mastocytes (HR = 1.87; 95% CI 1.00 to 3.46; p = 0.048) and a disease-free resection margin &lt;5 cm (HR = 0.52; 95% CI 0.27 to 1.02; p = 0.059). <h3>Conclusions:</h3> Submucosal plexitis is associated with early clinical recurrence and could be taken into account in studies searching for new treatment strategies in the immediate postoperative period.
Family and community factors associated with infant deaths that might be preventable
Authors: E. M Taylor, J. L Emery
Journal: BMJ (1983)

A detailed psychosocial study was made of all deaths in babies aged between 8 days and 2 years in Sheffield over two years.An identical assessment was made of a group of control children matched for age.Sixty five children who died and 102 controls were studied.Each index and control child was assessed for 13 potentially adverse social and family factors.The deaths were classified into causal groups.The families of children who died during the course of potentially treatable diseases (those with infections and those who presented as cot deaths but had treatable infection) had a significantly greater number of adverse social factors than the families of children who died from conditions with a poor prognosis, children who presented as completely unexplained cot deaths, and controls.The adverse factors studied, although often related to economic state, appeared to be independent of social class.
Letter: Plasma absorption of vitamin B12 in food
Authors: A. Doscherholmen
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The plasma absorption of vitamin B<sub>12</sub>in man following oral administration of physiologic doses of crystalline radioactive cobalt-labeled cyanocobalamin has been known for many years.<sup>1-3</sup>The absorption curve shows a delay in appearance of radioactivity for 3 to 4 hours, followed by a rapid rise to a maximum 8 to 12 hours after ingestion of the test dose. The subsequent falloff is gradual over a period of days. Since vitamin B<sub>12</sub>in nature is present in coenzyme forms<sup>4,5</sup>and bound to proteins,<sup>6</sup>the question was raised whether vitamin B<sub>12</sub>in food is absorbed into the blood in a manner similar to that of crystalline radioactive cobalt-labeled cyanocobalamin. We have tried to answer this question by studying the plasma absorption of radioactive isotope-labeled cyanocobalamin incorporated into food in vivo. An egg-laying hen was injected with cyanocobalamin Co 57, and the radioactive eggs
Encorafenib plus cetuximab with or without binimetinib for <i>BRAF</i> V600E-mutant metastatic colorectal cancer: Quality-of-life results from a randomized, three-arm, phase III study versus the choice of either irinotecan or FOLFIRI plus cetuximab (BEACON CRC).
Authors: Scott Kopetz, Axel Grothey, Eric Van Cutsem, Rona Yaeger, Harpreet Singh Wasan, Takayuki Yoshino, Jayesh Desai, Fortunato Ciardiello, Fotios Loupakis, Yong Sang Hong, Neeltje Steeghs, Tormod Kyrre Guren, Hendrik-Tobias Arkenau, Pilar Garcia-Alfonso, Ashwin Gollerkeri, Kati Maharry, Janna Christy-Bittel, Christopher Hunt Keir, Michael D Pickard, Josep Tabernero
Journal: Journal of Clinical Oncology (2020)

8 Background: In the BEACON CRC study, the triplet regimen of encorafenib (ENCO) + binimetinib (BINI) + cetuximab (CETUX) significantly improved overall survival (OS, HR:0.52, P &lt; 0.0001) and objective response rates (ORR, 26% vs 2%, P &lt; 0.0001) in patients (pts) with BRAF V600E metastatic colorectal cancer (mCRC) compared with current standard of care. This analysis focuses on the patient-reported quality of life (QOL) assessments from this study. Methods: The BEACON CRC study was a randomized, open-label, 3-arm, phase 3 global study which evaluated triplet (ENCO+BINI+CETUX) or doublet (ENCO+CETUX) vs. investigator’s choice of irinotecan + CETUX or FOLFIRI + CETUX in pts with BRAFV600E mCRC. QOL assessments (secondary endpoints in the trial) included the EORTC QOL Questionnaire (QLQ C30), Functional Assessment of Cancer Therapy Colon Cancer (FACT C), EuroQol 5D 5L, and Patient Global Impression of Change (PGIC). The primary assessment for the QOL variables was the time to definitive 10% deterioration between arms. Results: 665 pts were randomly assigned to receive either triplet (n = 224), doublet (n = 220), or control (n = 221). Reduction in the risk of QOL deterioration was an estimated 45% (HR 0.55, 95% CI: 0.43, 0.70) and 44% (HR 0.56, 95% CI: 0.44, 0.71) in EORTC QLQ C30 and FACT C assessments, respectively, in favor of the triplet regimen over control. For the doublet vs. control, reduction in risk of QOL deterioration was an estimated 46% (HR 0.54, 95% CI: 0.43, 0.69) and 43% (HR 0.57, 95% CI: 0.45, 0.72) in EORTC QLQ C30 and FACT C, respectively in favor of the doublet. Similar results were observed in EuroQol 5D 5L and PGIC assessments. There were no overall differences in QOL between triplet and doublet across the 4 instruments. Conclusions: In BEACON CRC, triplet and doublet demonstrated substantial improvement in patient-reported QOL assessments over the current standard of care in pts with BRAF V600E-mutant metastatic CRC whose disease had progressed after 1 or 2 prior regimens. Clinical trial information: NCT02928224.
Historical Developments and Perspectives in Inorganic Fiber Toxicity in Man
Authors: Irving J. Selikoff
Journal: Environmental Health Perspectives (1990)

The first patient known to have died from asbestosis (1900) began work in 1885, approximately 5 years after the industrial use of asbestos began in Britain. Mineral particles were found in his lungs. No special comment was made of their fibrous nature then nor when the first case was reported in 1924. The various neoplasms attributed to asbestos in the next decades posed an additional question: What influence did the fibrous shape of the particles have on carcinogenic potential? The cogency of the problem was amplified by the identification in humans of asbestos-like neoplasms with a fiber other than asbestos (erionite) and by the production of such neoplasms in experimental animals with a variety of man-made inorganic fibers, often used as substitutes for asbestos. The lessons learned about asbestos may help guide us in evaluating current fiber problems.
Die Behaarung des Menschen: Eine sexual- und konstitutions- wissenschaftliche Abhandlung.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
US reminder on mental health burden
Authors: None The Lancet
Journal: The Lancet (2000)

According to a new report by the United States Surgeon General, "about one in five Americans experiences a mental disorder over the course of a year". 15% of US adults seek some kind of mental health care each year; for those between the ages of 9 and 17 years, the proportion is even higher, 17%. And the high prevalence of mental disorders in the USA is not unique to that nation. Indeed, according to the Global Burden of Disease study, mental illness ranked second, behind cardio vascular disease in 1990.
Benefit of preimplant coronary sinus venogram and hemodynamic testing in patients selected for biventricular pacing in congestive heart failure J�rgen Vogt, Barbara Lamp, Johannes Heintze, Bert Hansky, Leon Krater, Gero Tenderich, Reiner K�rfer, Dieter Horstkotte. Heart Center Northrhine-Westfalia, Bad Oeynhausen, Germany
Journal: Journal of the American College of Cardiology (2001)
Predictors of 2-Year Outcome for Patients With Borderline Personality Disorder
Authors: John Gunderson
Journal: American Journal of Psychiatry (2006)

Objective: The primary purpose of this report was to investigate whether characteristics of subjects with borderline personality disorder observed at baseline can predict variations in outcome at the 2-year follow-up. Method: Hypothesized predictor variables were selected from prior studies. The patients (N=160) were recruited from the four clinical sites of the Collaborative Longitudinal Personality Disorders Study. Patients were assessed at baseline and at 6, 12, and 24 months with the Structured Clinical Interview for DSM-IV Axis I Disorders; the Diagnostic Interview for DSM-IV Personality Disorders, a modified version of that instrument; the Longitudinal Interval Follow-Up Evaluation; and the Childhood Experiences Questionnaire–Revised. Univariate Pearson's correlation coefficients were calculated on the primary predictor variables, and with two forward stepwise regression models, outcome was assessed with global functioning and number of borderline personality disorder criteria. Results: The authors' most significant results confirm prior findings that more severe baseline psychopathology (i.e., higher levels of borderline personality disorder criteria and functional disability) and a history of childhood trauma predict a poor outcome. A new finding suggests that the quality of current relationships of patients with borderline personality disorder have prognostic significance. Conclusions: Clinicians can estimate 2-year prognosis for patients with borderline personality disorder by evaluating level of severity of psychopathology, childhood trauma, and current relationships.
Building or Extending a Hospital Department: Radiology a Path through the Planning Minefield (9)
Authors: E J Roebuck, D J Manton, G L Fordham
Journal: Journal of the Royal Society of Medicine (1987)

This is the ninth of a series often articles on the planning and building of a new radiology department or the extension of an old one. While the series focuses on a radiology department, it will be of interest to anyone who is planning any part of a hospital, particularly in the detailed information about the planning process and the part to be played by hospital staff during the subsequent building and commissioning. An expanded version of this series is to be published as a book in 1988 by the Royal Society of Medicine, and will include a comprehensive index.
London Diplomates and the Title of "Dr."
Journal: BMJ (1901)

remainder had been trained in various public institutions.Some of the 6 or 7 per cent., as I happen to know, had re- ceived previous training in public institutions.Whether trAined privately or in institutions, the practical part of the instruction is almost invariably given by midwives.With regard to his third question as to the "misleading and unchecked use by midwives of the letters L.O. S. and of the terms 'qualified' and 'diploma,"' I would suggest his bringing before the Obstetrical Society the case of any mid- wife wilfully misrepresenting herself as a qualified medical practitioner, or in any other way misbehaving herself.I have not the slightest doubt that the Council will do all in its power to put a stop to such actions.But " F.R.C.S." should recollect 'that there is at present no legal bar to any one describing herself as a " qualified " or " diplom6ed " midwife, and that the Society cannot go further than the law.The
Final Results of a Phase 2 NCI Multicenter Study of Romidepsin in Patients with Relapsed Peripheral T-Cell Lymphoma (PTCL).
Authors: Richard Piekarz, John Wright, Robin Frye, Steven L Allen, David Joske, Mark Kirschbaum, Ian D. Lewis, Miles Prince, Sonali Smith, Elaine S Jaffe, Susan Bates
Journal: Blood (2009)
A Manual of Proctology.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Correction to the Research Article Titled: “HIV-1 Concentrations in Human Breast Milk Before and After Weaning” by L. Kuhn, H.-Y. Kim, J. Walter, D. M. Thea, M. Sinkala, M. Mwiya, C. Kankasa, D. Decker, G. M. Aldrovandi
Journal: Science Translational Medicine (2013)
Correction: “Clinical utility of hepatitis B surface antigen quantitation in patients with chronic hepatitis B: A review”
Journal: Hepatology (2011)

In the June 2011 issue of HEPATOLOGY, in the article entitled ''Clinical utility of hepatitis B surface antigen quantitation in patients with chronic hepatitis B: A review'' (volume 53, pages 2121-2129) the data in Tables 2 and3 are to be corrected as listed below:On page 2124, under the heading ''Predicting responses to IFN-based therapy with HBsAg Levels'', the percentages in the first sentence are 35 and 25, respectively:Because a sustained response to pegylated interferon (PEG-IFN) is achieved in only approximately 35% of HBeAg-positive patients and 25% of HBeAg-negative patients, identifying a potential treatment success is valuable for both the patient and the physician.A number of groups have retrospectively analyzed response rates in PEG-IFN cohorts with respect to on-treatment HBsAg declines.
Foodborne Outbreaks of Enterotoxigenic Escherichia coli— Rhode Island and New Hampshire, 1993
Journal: JAMA (1994)

Infections with enterotoxigenic Escherichia coli (ETEC) are a frequent cause of diarrhea in developing countries but not in the United States and other industrialized countries. This report describes two foodborne ETEC outbreaks that occurred in the United States in 1993.
Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia
Authors: Jan A. Deprest, Kypros H. Nicolaides, Alexandra Benachi, Eduard Gratacos, Greg Ryan, Nicola Persico, Haruhiko Sago, Anthony Johnson, Mirosław Wielgoś, Christoph Berg, Ben Van Calster, Francesca M. Russo
Journal: New England Journal of Medicine (2021)

Observational studies have shown that fetoscopic endoluminal tracheal occlusion (FETO) has been associated with increased survival among infants with severe pulmonary hypoplasia due to isolated congenital diaphragmatic hernia on the left side, but data from randomized trials are lacking.
Factors Determining the Outcome of Chemotherapy in Infections of the Urinary Tract
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Noncariogenic Not Noncarcinogenic
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal