tbuckley/cabot-search huggingface dataset:
Bird
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, December 1, 1967, to January 1, 1968
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Manuscripts Approved for JNCI, December 1, 1967, to January 1, 1968 Get access JNCI: Journal of the National Cancer Institute, Volume 40, Issue 2, February 1968, Page 429, https://doi.org/10.1093/jnci/40.2.429 Published: 01 February 1968
The APPLE Association President's Message
Authors: Masatoshi Kudo, Masatoshi Kudo, Byung Ihn Choi, Hyun Jeong Park, Eun Sun Lee, Sung Bin Park, Jong Beum Lee, Helen M. Parsons, Quyen Chu, Jordan J. Karlitz, Jennifer L. Stevens, Linda C. Harlan, Tatsuya Yamashita, Takeshi Terashima, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko, Takashi Kumada, Masatoshi Kudo, Masashi Hirooka, Kunihiko Tsuji, Ei Itobayashi, Kazuya Kariyama, Toru Ishikawa, Kazuto Tajiri, Toshifumi Tada, Hidenori Toyoda, Kazuhiro Nouso, Hideki Kawasaki, Yoichi Hiasa, Kojiro Michitaka, Atsushi Hiraoka, Hironori Ochi, Kouji Joko, Tadaaki Arizumi, Kazuomi Ueshima, Mina Iwanishi, Tomohiro Minami, Hirokazu Chishina, Masashi Kono, Masahiro Takita, Norihisa Yada, Satoru Hagiwara, Yasunori Minami, Hiroshi Ida, Yoriaki Komeda, Mamoru Takenaka, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Masatoshi Kudo, Mengensatzproduktion, Druckerei Stückle, Druckerei Stückle, on behalf of the Real-Life Practice Experts for HCC (RELPEC) Study Group and HCC 48 Group (hepatocellular carcinoma experts from 48 clinics)
Journal: Liver Cancer (2017)
Nanotechnology in the Environmental Health Sciences
Journal: Environmental Health Perspectives (2005)

Among the newest buzzwords in biomedical science is nanotechnology: small is big!The vision for nanotechnology has existed for many years-remember Isaac Asimov's Fantastic Voyage-but the ability to manipulate individual atoms to engineer devices at the nanoscale is new.A number of benefits arise at the nanoscale, from the practical (reagent utilization and the ability to multiplex) to the emergence of new properties (optical and electrical).The intent here is to briefly outline some ways nanotechnology will impact the environmental health sciences.
Abstract 3674: Protein levels of Piwi-like 1 and -2 protein are prognostic factors for muscle invasive urothelial bladder cancer patients
Authors: Markus Eckstein, Rudolf Jung, Katrin Weigelt, Danijel Sikic, Robert Stöhr, Carol Geppert, Abbas Agaimy, Verena Lieb, Arndt Hartmann, Bernd Wullich, Sven Wach, Helge W. Taubert
Journal: Cancer Research (2019)

Abstract The Piwi-like proteins are essential for stem-cell maintenance and self-renewal in all multicellular organisms. We analyzed the expression of Piwi-like 1 and Piwi-like 2 by immunohistochemistry (IHC) in 95 muscle invasive bladder cancer (MIBC) samples using tissue microarray. Application of an immunoreactive score (IRS) revealed 37 and 45 patients who were Piwi-like 1 and -2 positive (IRS&amp;gt;2). IHC results were correlated with clinico-pathological and survival data. The expression of both proteins was positively correlated with each other, lymph node metastasis and expression of CK20 and GATA 3. A negative correlation for both proteins was detected for disease-specific survival (DSS), recurrence, Ki67/MIB1 proliferation index, and CK5 expression. Detection of Piwi-like 1 protein positivity was associated with poor DSS (P=0.019; log rank test, Kaplan-Meier analysis), and in multivariate Cox’s analysis (adjusted to tumor stage and tumor grade), it was an independent prognostic factor for DSS (RR=2.16; P=0.011). Piwi-like 2 positivity was associated with DSS (P=0.008) and relapse-free survival (RFS; P=0.040), and in multivariate Cox’s analysis, Piwi-like 2 positivity was an independent prognostic factor for DSS (RR=2.46; P=0.004) and RFS (RR=3.0; P=0.003). Most interestingly, in the basal type patient subgroup (CK5+/CK20−), Piwi-like 2 positivity was associated with poorer DSS, OS and RFS (P&amp;lt;0.001, P&amp;lt;0.001 and P=0.006; log rank test). In multivariate analysis, Piwi-like 2 positivity was an independent prognostic factor for DSS (RR=10.49; P=0.001), OS (RR=5.71; P=0.001) and RFS (RR=6.35; P=0.016). In summary, Piwi-like 1 and -2 positivity are associated with clinico-pathological factors and survival. Therefore, both Piwi-like proteins are suggested as biomarkers for MIBC patients. Citation Format: Markus Eckstein, Rudolf Jung, Katrin Weigelt, Danijel Sikic, Robert Stöhr, Carol Geppert, Abbas Agaimy, Verena Lieb, Arndt Hartmann, Bernd Wullich, Sven Wach, Helge W. Taubert. Protein levels of Piwi-like 1 and -2 protein are prognostic factors for muscle invasive urothelial bladder cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3674.
Different adhesion types and active sensitivity of platelet subpopulations
Authors: B. Zhao, T.J. Filler, C.H. Rickert, J.F. Liu, A.D. Skholl‐Engberts, V. Gurevich
Journal: American Journal of Hematology (1996)

Two different adhesion patterns of blood platelets with different sensitivity to adenosine were demonstrated by means of reflection contrast microscopy with consecutive image analysis and cell affinity chromatography. High-performance liquid chromatography revealed that thrombin-induced serotonin release of adenosine-sensitive platelets was lower than that of adenosine-resistant cells. Our results indicate platelet heterogeneity and suggest that the platelets with lower adenosine sensitivity may be actively involved in the early interaction between platelets and injured endothelium. © 1996 Wiley-Liss, Inc.
Radium-226-contaminated drinking water: hypothesis on an exposure pathway in a population with elevated childhood leukemia.
Authors: W Hoffmann, A Kranefeld, I Schmitz-Feuerhake
Journal: Environmental Health Perspectives (1993)

A recent epidemiological survey on childhood malignant disease in the region of Ellweiler, Rheinland-Pfalz, Germany, revealed a significantly increased incidence of childhood leukemia, but observed incidences of lymphoma and solid tumors were normal. Established risk factors such as individual exposure to chemicals as well as hereditary genetic disorders were ruled out in interviews with the patients or their families. The general population in the region, however, is subjected to considerable doses of ionizing radiation due to high levels of external gamma radiation and high activities of indoor radon. Radiation-specific chromosome aberrations were found in one of two healthy siblings and one father of leukemia patients as well as in any of three probands living in houses with high indoor radon activities. Radon and natural gamma radiation, however, cannot explain the geographical pattern of the cases. Four out of seven cases were observed in two particular villages near a uranium processing plant. The drinking water of these villages partly came from a small river that was contaminated with radium-226 washed out from the dumps of the uranium plant. Only sparse measurements of 226Ra are available, but derived red bone marrow doses for children in the two villages obtained from a simple radio-ecological model show the significance of the drinking water pathway. Prenatal 226Ra exposure of fetuses due to placental transfer and accumulation may have led to significant doses and may explain the excess cases of childhood leukemia in the region even in quantitative terms.
Erratum: TMEM140 is associated with the prognosis of glioma by promoting cell viability and invasion
Authors: Bin Li, Ming-Zhu Huang, Xiao-Qiang Wang, Bang-Bao Tao, Jun Zhong, Xu-Hui Wang, Wen-Chuan Zhang, Shi-Ting Li
Journal: Journal of Hematology & Oncology (2015)
Health Effects of Electric and Magnetic Fields: Overview of Research Recommendations
Authors: David A. Savitz
Journal: Environmental Health Perspectives (1993)

We developed a series of articles concerning epidemiologic research on potential health effects of electric and magnetic fields.Our goal was to identify methodological issues that have arisen through past studies of cancer, reproduction, and neurobehavioral outcomes in order to suggest strategies to extend knowledge.Following an overview of relevant physics and engineering principles, cancer epidemiology of electric and magnetic fields is discussed separately with a focus on epidemiologic methods and cancer biology, respectively.Reproductive health studies, many of which focus on exposure from video display terminals are then summarized, followed by an evaluation of the limited literature on neurobehavioral out- comes, including suicide and depression.Methodological issues in exposure assessment are discussed, focusing on the challenges in residential exposure assessment and interpretation of wire configuration codes.An overview offers recommendations for priorities across these topic areas, emphasizing the importance of resolving the question of wire codes and childhood cancer.Collectively, these articles provide an array of observa- tions and suggestions regarding the epidemiologic literature, recognizing the potential benefits to science and public policy.
Environment for learning
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma
Authors: Weikun Xiao, Rongyu Zhang, Alireza Sohrabi, Arshia Ehsanipour, Songping Sun, Jesse Liang, Christopher M. Walthers, Lisa Ta, David A. Nathanson, Stephanie K. Seidlits
Journal: Cancer Research (2019)
Endocrine exophthalmos.
Authors: C W Havard
Journal: BMJ (1972)

<h3>Background:</h3> B cell depletion therapy (BCDT) has recently been used with success to treat patients with rheumatoid arthritis and systemic lupus erythematosus (SLE). As antiphospholipid antibodies have been implicated in the pathogenesis of the antiphospholipid syndrome (APS), we asked the question whether BCDT affects levels of IgG anticardiolipin antibodies (aCL) in our cohort of 32 SLE patients given this treatment. <h3>Methods:</h3> We identified seven SLE patients who had undergone BCDT and had had at least two moderate positive aCL titres at least 12 weeks apart. Of these only one patient had APS. IgG aCL were measured at time 0 and 6–9 months post BCDT. <h3>Results:</h3> At time 0, the mean IgG aCL level was 20.6 standardized IgG antiphospholipid units (GPLU) (range (SD) 10–32, (10.1), normal level &lt;5). At 6–9 months post depletion the IgG aCL levels in six of the seven patients was undetectable and in the other patient the level reduced from 25 GPLU to 15 GPLU (p&lt;0.005, two-tailed paired t test). At baseline, only one patient had a mildly positive anti-β<sub>2</sub>-glycoprotein I (β<sub>2</sub>GPI) antibody level at 30% (compared to an in-house standard), which fell to 5% post-BCDT. <h3>Conclusions:</h3> This small observational study in patients with SLE is the first to demonstrate that BCDT results in a significant reduction in levels of IgG aCL.
SMBE Editors and Council
Authors: Walter Fitch, Masatoshi Nei, Marcy Uyenoyama, Elizabeth Raffaele, G Golding, Richard Lewontin, Howard Ochman, Ken Wolfe, Charles Aquadro, Jody Hey, Manyuan Long, John Archibald, Robin Bush, Soojin Yi
Journal: Molecular Biology and Evolution (2011)
'Desirable weight' goes up in new guidelines
Authors: C. Marwick
Journal: JAMA (1991)

A NEW edition of the dietary guidelines has been issued by the federal Departments of Agriculture and Health and Human Services. In seven recommendations it updates the previous edition, issued in 1985: (1) Eat a variety of foods. (2) Maintain a healthy weight. (3) Choose a diet low in fat. (4) Consume plenty of vegetables, fruits, and grain products. (5) Use sugar in moderation. (6) Use salt and sodium moderately. (7) If drinking alcoholic beverages, do so in moderation. Unlike the two previous editions of the guidelines, the latest version is specific on certain issues. For example, it recommends that women take only one alcoholic drink per day; men should limit themselves to two. Regarding dietary fat, the guidelines recommend that the total should amount to no more than 30% of calories, preferably less. Thus, in an 8.4-kJ/d (2000 calorie/d) diet, there should be no more than 67 g of
Abstract 18549: High-sensitivity Troponin I in Stable Patients With Atherosclerotic Disease in the TRA2°P- TIMI 50 Trial
Authors: Alon Eisen, Marc P Bonaca, Petr Jarolim, Benjamin M Scirica, Erin A Bohula, Sabina A Murphy, Eugene Braunwald, David A Morrow
Journal: Circulation (2015)

Background: Cardiac troponin I, measured with a high-sensitivity assay (hsTnI), is a well-established prognosticator in patients with acute coronary syndromes. However, its prognostic role in patients with stable atherosclerotic disease, particularly with respect to new or recurrent myocardial infarction (MI), is less defined. Methods: We measured hsTnI (Abbott ARCHITECT) in 19,429 patients with prior MI, ischemic stroke, or symptomatic peripheral arterial disease, who had available baseline samples in the TRA 2°P-TIMI 50 trial of the platelet inhibitor vorapaxar vs. placebo. hsTnI concentration was categorized into 5 groups based on the detection limit (1.9 ng/L), the 99th percentile reference limit (26 ng/L), and tertiles in between (1.9-26 ng/L). The median follow-up was 2.5 years. Sensitivity analyses excluded patients with a history of MI in the prior 30 days and tested sex-specific cutpoints. Results: Higher baseline hsTnI levels were associated with older age, male sex, and an increased burden of atherosclerotic disease. hsTnI identified a graded risk of cardiovascular (CV) death, MI, or stroke with a consistent pattern across each element of this composite, in particular CV death and MI (Figure). This risk relationship was independent of established clinical risk indicators, B-type natriuretic peptide and C-reactive protein (adj-HR 2.17, 95% CI 1.61-2.92 for hsTnI &gt;26 ng/L) and was consistent after excluding pts with recent MI (adj-HR 2.69, 95% CI 1.95-3.71 for hsTnI &gt;26 ng/L). There were no meaningful differences using sex-specific hsTnI cutpoints. The interaction with efficacy of vorapaxar vs. placebo according to hsTnI will be presented. Conclusion: When measured in stable patients with established atherosclerosis, hsTnI concentrations, even below the 99th percentile reference limit, effectively stratified the risk of new or recurrent MI.
Analysis of real world treatment compliance in a cohort of 2,395 patients with metastatic renal cell carcinoma (mRCC).
Authors: Jay Margolis, Nicole Princic, Justin Doan, Gregory Lenhart, Robert Motzer
Journal: Journal of Clinical Oncology (2015)

4546 Background: Given recent European data highlighting the importance of real world dose intensity, we sought to examine real world compliance in patients with mRCC from a US perspective (Cancer Med 2014; 3(6): 1517-26). Methods: In this retrospective cohort study, we used MarketScan Commercial and Medicare Supplemental administrative claims databases to select patients newly diagnosed with mRCC (index event) during 1/1/2006 to 3/31/2014. First line therapy (1L) was defined by first prescription record post-index for any approved mRCC therapy and a change in line of therapy was defined by therapy switch. Compliance was measured using the medication possession ratio (MPR) during each and all lines of therapy. MPR was defined as total days of supply during the treatment period divided by the total treatment period until the start of the last treatment. Results: A total of 2,395 mRCC patients were identified as initiating 1L therapy. Across all treatments the mean MPR was 0.77 ± 0.20, which increased over time from 0.73 in 2006 to 0.81 in 2013. More than 50% of patients were noncompliant, defined as MPR < 80%. During 1L, patients treated with sunitinib had significantly lower mean MPR compared with most other treatments (table). Compliance was found to increase during 2L (0.85 ± 0.18) vs 1L (0.80 ± 0.19). A larger proportion of patients who initiated therapy with temsirolimus were compliant compared with those who initiated with sunitinib (62% vs 38%). Conclusions: Over half of treated mRCC patients in this study were found to be noncompliant with therapy. There were differences found between individual drugs. Compliance was significantly better with IV administered temsirolimus relative to the reference oral therapy, sunitinib. Real-world analysis of adherence behaviors provides information for clinicians in monitoring and optimizing targeted therapy. MPR in 1L and all lines. Compliance Sunitinib* Sorafenib Pazopanib Everolimus Temsirolimus 1L MPR, mean (SD) 0.76 (0.19) 0.84 (0.19) 0.86 (0.19) 0.89 (0.14) 0.83 (0.19) All lines, MPR, mean (SD) 0.74 (0.20) 0.78 (0.23) 0.84 (0.20) 0.76 (0.24) 0.81 (0.19) * Reference group. In 1L, all differences were significant at P < 0.05.
Abstract 150: Stromal cell plasticity and immune surveillance revealed by single-cell transcriptomics
Authors: Claire Regan, Yuan Hao, Jonathan Preall
Journal: Cancer Research (2019)

Abstract Pancreatic ductal adenocarcinomas are typically characterized by a highly desmoplastic stroma, which is dense in collagen and other extracellular matrix components that limit access to the growing tumor by immune cells and targeted therapies. ECM components are mainly deposited by cancer-associated fibroblasts (CAFs), which are thought to arise primarily from pancreatic stellate cells and have been shown to polarize into at least two distinct subtypes within the tumor microenvironment in response to extracellular ligands. Recent studies have suggested potentially antagonistic roles for the different CAF subtypes in either promoting or restraining tumor growth. While depletion of the restrictive desmoplasia is likely to be a desirable therapeutic avenue, a complete understanding of phenotypic variation and interconversion between CAF populations will be essential for designing targeted therapies. Using single-cell RNAseq, we have profiled the non-immune stromal cells of pancreatic ductal adenocarcinomas in the KPC mouse model, as well as from orthotopically transplanted organoid-derived pancreatic tumors. In addition to the canonically reported myofibroblastic and inflammatory CAF subtypes, we observe at least one additional distinct type-I collagen expressing fibroblastic cell type in the tumor microenvironment. The high degree of transcriptional divergence suggests that these CAFs may arise from distinct progenitors, whereas myo- and inflammatory-CAFs lie along a continuous pseudotemporal gradient marked by signatures of transcriptional programs driven by extracellular ligand signaling, including Wnt-family genes. Our single-cell transcriptomic results point toward pathway utilization that could be exploited for modulating PDAC desmoplasia and enabling targeted combination therapies. Citation Format: Claire Regan, Yuan Hao, Jonathan Preall. Stromal cell plasticity and immune surveillance revealed by single-cell transcriptomics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 150.
Health System Reform: The Case for a Single-Payer Approach
Authors: A. Bruce Reid
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Representative McDermott's<sup>1</sup>comments regarding a Canadian single-payer system for US health care reform relies on altruism and does not reflect the reality of the system. I am a third-generation physician, born and raised in the Canadian health care system, and I have seen the single-payer system in Canada develop and flounder under a burgeoning economic crisis. Patient access is not unfettered with free choice of provider. Access is limited by excessive patient loads on primary care physicians and limited specialist availability, making 2-month and 3-month referral waits common. Global budgets and caps have not been effective at cost containment as the Canadian health care system has experienced medical cost increases parallel to that of the United States. The only effects of global budgeting are economic rationing of care through closure of hospital beds, limiting of diagnostic equipment, and long waiting lists for elective surgery. Negotiations with
CLEVER MALINGERING.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal