tbuckley/cabot-search huggingface dataset:
Copper-Binding Proteins in Liver of Bluegills Exposed to Increased Soluble Copper under Field and Laboratory Conditions
Authors: Florence L. Harrison, Jacqueline R. Lam
Journal: Environmental Health Perspectives (1986)

Livers from bluegills exposed to increased soluble copper (Cu) under field and laboratory conditions were analyzed to determine the concentration and distribution of Cu in metalloproteins of different molecular size.Analyses were performed on bluegills collected from the impoundment of the H. B. Robinson Steam Electric Plant (Florence, SC) near the effluent discharge from the power plant, near the water intake to the cooling system, and from a control pond as well as on bluegills exposed under controlled laboratory conditions.Metalloproteins were separated into low molecular weight (LMW), intermediate molecular weight (IMW), and high molecular weight (HMW) fractions by using high-performance liquid chromatography.In the field-exposed bluegills, Cu concentrations in the LMW, IMW, and HMW fractions were highest in bluegills from the discharge site and lowest in those from the control pond.In the laboratory-exposed bluegills, Cu concentrations in the fractions increased with exposure concentration and time.Concentrations of Cu in the LMW protein fraction and pellet of bluegills exposed to 160 jig Cu/L appeared to plateau with long exposure times, whereas those in the HMW fraction continued to increase.Bluegills maintained in 80 ,ug Cu/L water at pH 5.5 accumulated lower concentrations of Cu in the LMW and pellet fractions and higher amounts in the HMW than in those maintained in 80 jig Cu/L at pH 7.0.Mortality was dependent on exposure concentration and duration and was higher in bluegills maintained in water at pH 5.5 than at pH 7.0.
Comparison between Free Thyroxine Index and effective Thyroxine Ratio
Authors: M. G. Wells, C. E. Andrew
Journal: BMJ (1974)

residual radioactivity in serum after incubation with resin is assessed and therefore a free thyroxine index is calculated as de- scribed by Dr. D'Haene and his colleagues by dividing P.B.I. by T-3 B.C. index.We hope this comment clarifies the situation and reinforces the need for a clear understanding of the method used to assess the T-3 resin uptake.-Weare, etc.,
THE BLOOD CHANGES IN MUMPS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunobiology Of Cr2, The Lymphocyte B Receptor For Epstein-Barr Virus And The C3d Complement Fragment
Authors: N. Cooper
Journal: Annual Review of Immunology (1988)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Results of Lung Resection in Tuberculosis Four to Seven Years After Operation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organ Biomarker Responses in Patients with Light Chain Amyloidosis Treated with NEOD001 Are Independent of Previous Hematologic Response
Authors: Michaela Liedtke, Raymond L. Comenzo, Heather Landau, Vaishali Sanchorawala, Brendan M. Weiss, Jeffrey A. Zonder, Jackie Walling, Gene G. Kinney, Martin Koller, Dale B. Schenk, Spencer D. Guthrie, Enchi Liu, Morie A. Gertz
Journal: Blood (2016)
ALCOHOL AND LONGEVITY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebellar Development and Clinical Outcome in Attention Deficit Hyperactivity Disorder
Authors: Susan Mackie
Journal: American Journal of Psychiatry (2007)

Objective: Anatomic magnetic resonance imaging (MRI) studies have detected smaller cerebellar volumes in children with attention deficit hyperactivity disorder (ADHD) than in comparison subjects. However, the regional specificity and longitudinal progression of these differences remain to be determined. The authors compared the volumes of each lobe of the cerebellar hemispheres and vermis in children with ADHD and comparison subjects and used a new regional cerebellar volume measurement to characterize the developmental trajectory of these differences. Method: In a longitudinal case-control study, 36 children with ADHD were divided into a group of 18 with better outcomes and a group of 18 with worse outcomes and were compared with 36 matched healthy comparison subjects. The volumes of six cerebellar hemispheric lobes, the central white matter, and three vermal subdivisions were determined from MR images acquired at baseline and two or more follow-up scans conducted at 2-year intervals. A measure of global clinical outcome and DSM-IV criteria were used to define clinical outcome. Results: In the ADHD groups, a nonprogressive loss of volume was observed in the superior cerebellar vermis; the volume loss persisted regardless of clinical outcome. ADHD subjects with a worse clinical outcome exhibited a downward trajectory in volumes of the right and left inferior-posterior cerebellar lobes, which became progressively smaller during adolescence relative to both comparison subjects and ADHD subjects with a better outcome. Conclusions: Decreased volume of the superior cerebellar vermis appears to represent an important substrate of the fixed, nonprogressive anatomical changes that underlie ADHD. The cerebellar hemispheres constitute a more plastic, state-specific marker that may prove to be a target for clinical intervention.
THU0086 FLT3L-Dependent CD103+ DC are Crucial for the Initiation and Maintenance of Collagen-Induced Arthritis
Authors: M. I. Ramos, S. Aarrass, S. Jacobsen, P. P. Tak, M. C. Lebre
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Dendritic cells (DCs) are a heterogeneous population of antigen-sensing and-presenting cells that play an important role for the initiation of protective and pathogenic immunity. Flt3L is a growth factor that can drive DC development from bone marrow (BM) progenitors and it is crucial for steady-state DC maintenance. Collagen-induced arthritis (CIA) induction requires dermal DC uptake, processing, migration and presentation of antigen to lymph node (LN) T cells. <h3>Objectives</h3> The objective of this study was to find the mechanism of protection in CIA observed in mice lacking Flt3L (Flt3L-/-). <h3>Methods</h3> CIA was induced in Flt3L-/- and WT littermates. The severity of the arthritis was assessed using an established semiquantitative scoring system (0–4). In vitro uptake and migration was assessed by using BM-DC (differentiated with GM-CSF for 9 days). OVA-FITC was injected intradermally in Flt3L-/- and WT animals, after 36h LNs were collected and the number of FITC positive cells was determined. Antigen presentation was studied by adoptive transfer of CFSE-labeled OT-I or OT-II T cells + OVA (i.d.) into Flt3L-/- and WT animals. After 3 days LNs were collected and T cell proliferation was analyzed by CFSE dilution. <h3>Results</h3> Flt3L-/- mice (steady-state) have severe reductions in DC populations in lymphoid and non-lymphoid organs. Flt3L-/- mice are protected from CIA showing impaired T and B cell responses. Flt3L-/- mice have reduced dermal CD11b+ DCs and CD103+ DCs are almost absent. In addition, the amount of DCs carrying antigen reaching the LN in Flt3L-/- mice was reduced compared with WT. In vitro and in vivo experiments using BMDCs demonstrated that Flt3L-/- BMDCs have the same capacity to uptake and migrate as WT BMDCs. Moreover, adoptive transfer of OT-I and OT-II T cells + OVA in Flt3L-/- mice resulted in a dramatic reduction of total cell proliferation and more importantly less divisions compared with WT animals. FACS analysis of WT and Flt3L-/- mice synovium at the acute phase of CIA showed that CD11b+ DC are present and increased in arthritic animals compared with immunized but not arthritic animals. CD103+DC are only present in WT animals, and increased in animals with a high clinical score. <h3>Conclusions</h3> Our data shows that antigen presentation in Flt3L-/- mice is impaired. As CD103+ DC are important in presenting and cross-presenting antigens our data reveals an important role for CD103+ DC in both induction and maintenance of CIA. Specifically targeting CD103+ DC could provide a novel anti-rheumatic strategy. <h3>Disclosure of Interest</h3> M. Ramos: None Declared, S. Aarrass: None Declared, S. Jacobsen: None Declared, P. Tak Employee of: GlaxoSmithKline, Stevenage, U.K., M. C. Lebre: None Declared
Chimeric Antigen Receptor T Cells Targeting CD19 and Ibrutinib for Chronic Lymphocytic Leukemia
Authors: Julio Delgado, Miguel Caballero-Baños, Valentín Ortiz-Maldonado, Maria Castellà, Laura Magnano, Manel Juan, Álvaro Urbano-Ispizua
Journal: HemaSphere (2019)
AFTER-CARE PROBLEMS.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DIETETIC TREATMENT OF HYPERTENSION AND NEPHRITIS
Authors: P. W. C.
Journal: Annals of Internal Medicine (1950)

Editorial1 May 1950THE DIETETIC TREATMENT OF HYPERTENSION AND NEPHRITISP. W. C.P. W. C.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-5-989 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany therapeutic procedures for the relief of hypertension, dietetic, medicinal and surgical, have been proposed during the past 50 years. When advocated with sufficient vigor and authority and supported by statistical evidence which seemed imposing, many of these have stimulated wide spread interest which has gradually waned as the results in practice fell far short of the expectations which had been aroused. At present we are near—probably a little past—the crest of a new wave of enthusiasm which followed the report of Kempner1of the successful use of a "rice-fruit-sugar diet" for the treatment of nephritis and hypertension. A current...1 Kempner W: The treatment of kidney disease and hypertensive vascular disease with rice diet, North Carolina M. J. 5: 125-131, 1944. Google Scholar2 Kempner W: Compensation of renal metabolic dysfunction. Treatment of kidney disease and hypertensive vascular disease with rice diet, III, North Carolina M. J. 6: 61-87, 117-161, 1945. Google Scholar3 AllenSherrill FMJW: The treatment of arterial hypertension, J. Metabol. Research 2: 429-545, 1922. Google Scholar4 SchwartzMerlis WBJK: Nitrogen balance studies on the Kempner rice diet, J. Clin. Investigation 26: 1060-1071, 1947. MedlineGoogle Scholar5 Kempner W: Treatment of hypertensive vascular disease with rice diet, Am. J. Med. 4: 545-577, 1948. CrossrefMedlineGoogle Scholar6 Kempner W: Treatment of heart and kidney disease and of hypertensive and arteriosclerotic vascular disease with the rice diet, Ann. Int. Med. 31: 821-856, 1949. LinkGoogle Scholar7 Cantor HE: Ambulatory treatment of hypertension with the rice diet, Pennsylvania M. J. 51: 1411-1413, 1948. MedlineGoogle Scholar8 ContrattoRogers AWMB: The use of the rice diet in the treatment of hypertension in nonhospitalized patients, New England J. Med. 239: 531-536, 1948. CrossrefMedlineGoogle Scholar9 Loofbourow DG: The effect of the rice diet on the blood pressure in essential hypertension, New England J. Med. 240: 910-914, 1949. CrossrefMedlineGoogle Scholar10 ChapmanGibbons CBTB: The diet and hypertension, Medicine 29: 29-69, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byControlled Observations on the Effect of Low Sodium Dietotherapy in Essential HypertensionEffects of diet in essential hypertension 1 May 1950Volume 32, Issue 5Page: 989-995KeywordsDietHypertensionMotivationNephritis ePublished: 1 December 2008 Issue Published: 1 May 1950 PDF downloadLoading ...
SCHOOL TIE-II
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stomach and bleeding
Authors: A Kuibba, G Haydon, C Hayes, I Vitro, Model Af, R Spiller
Journal: Gut (1996)

The somatostatin analogue octreotide has been used to stop peptic ulcer haemorrhage, alhough its mndinism ofaction is unclear .It may exert an effect by reducing gasroduodenal mucosal blood flow.Mucosal blood flow was measured using a Laser Doppler Flowmeter.The Doppler probe was positioned in the upper ri al tract (either endoscopicay or via a sa1l gastrostouy) of seven rabbits .Preiinduary experimets showed the mehod to be reproducible, non invasive ad simple.Mucosal blood flow was dereaed in a dose dependent manner in the body(l93.5Uto 71.2SU) and antrum(154.8U to 34.7U) ofthe stomach ad duodenum(187.SU to 67.SU) by doses of octreotide ranging from 10-50 microgm/kg ofbody weight .The change was not associated with systemic haemadyamic changes.Vasopressi(1 microgram/kg) but not normal saline also reduced gastroduodenal mucoal blood flow , but this was associated with profound bradycardia and a fall in non gastrointestinal tisse pefuion.Gastroduodenal mucosal blood flow is reuced in a dose dependent manner by octreotide ugges tat this agent may be helpful in the management ofbleeding from gastroduodenal ulcer disease and gastitis .
Fatal Liver Disease Subsequent to Intravenous Administration of Tetracycline in High Dosage
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response
Authors: R. P. GALE
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Response Get access ROBERT PETER GALE ROBERT PETER GALE Transplantation Biology Program Division of Hematology/Oncology School of Medicine University of CaliforniaLos Angeles, CA 90024-1678 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 20, 21 December 1988, Page 1641, https://doi.org/10.1093/jnci/80.20.1641-a Published: 21 December 1988
Preliminary FoodNet Data on the Incidence of Foodborne Illnesses—Selected Sites, United States, 2000
Journal: JAMA (2001)

In the United States, an estimated 76 million persons contract foodborne illnesses each year. CDC's Emerging Infections Program Foodborne Diseases Active Surveillance Network (FoodNet) collects data on 10 foodborne diseases in nine U.S. sites. FoodNet follows trends in foodborne infections by using laboratory-based surveillance for culture-confirmed illness caused by several enteric pathogens commonly transmitted through food. This report describes preliminary surveillance data for 2002 and compares them with 1996-2001 data. The data indicate a sustained decrease in major bacterial foodborne illnesses such as Campylobacter and Listeria, indicating progress toward meeting the national health objectives of reducing the incidence of foodborne infections by 2010 (objectives 10-1a to 10-1d). However, the data do not indicate a sustained decline in other major foodborne infections such as Escherichia coli O157 and Salmonella, indicating that increased efforts are needed to reduce further the incidence of foodborne illnesses.
Contempo '79
Authors: M. THERESE SOUTHGATE
Journal: JAMA (1979)

LAST year we published a special issue ofThe JOURNAL(Feb 6, 1978) in which each member of our Editorial Board capsuled into a thousand words or so two or three of the noteworthy aspects of his specialty at that time. The result was a tidy little package of some 30 pages that contained the essence of the experience of our Board members. We called the issue COMTEMPO, a name we chose deliberately because it had no dictionary definition. Our goal was not to limit but to stimulate. We even hoped that the issue might become an annual feature. Well before the issue was a month old we knew that there would have to be a next issue and that it would have to be considerably expanded. Whereas there are some 40 officially recognized specialties and subspecialties in medicine, we could cover less than half that number without going beyond
Massachusetts Medical Society
Authors: Harriet L. Hardy
Journal: New England Journal of Medicine (1959)

CHANNING FROTHINGHAM, M.D. 1881–1959In the death of Dr. Channing Frothingham on August 11, 1959, at the age of seventy-eight, the Massachusetts Medical Society has lost one of its most dynamic, energetic and cheerfully independent members. Of a forthright and engaging personality, Dr. Frothingham was warmly esteemed by all with whom he came in intimate contact, regardless of their differences of opinion.A graduate of Harvard College in 1902 and of Harvard Medical School in 1906, Dr. Frothingham served as physician at the Peter Bent Brigham Hospital from 1912 to 1932, as consulting physician from 1923 to 1947 and as . . .