tbuckley/cabot-search huggingface dataset:
<i>Circulation Research</i> Thematic Synopsis
Journal: Circulation Research (2012)

The goal of Thematic Synopses is to provide our readers with a concise but comprehensive overview of the work published in Circulation Research, which we hope will keep our readers abreast of recent scientific discoveries and facilitate discussion, interpretation, and integration of the findings.These collections of articles are organized thematically and the papers listed in chronological order, beginning with the most recent ones.In each synopsis, the top downloaded original research articles (normalized to time since publication) are highlighted in yellow.Review articles are also included with titles highlighted in blue and the summary of each is provided.Instead of using abstracts, we have elected to publish the Novelty and Significance section of each article, which we believe provides a clear précis of the salient findings and their implications in a language that is easily understandable by the non-initiated.This will enable readers who are not experts in a particular field to grasp the significance and impact of work performed in other fields.It is our hope and expectation that Thematic Synopses will help readers to gain a broader awareness and a deeper understanding of the status of research across the vast landscape of cardiovascular research.-
Respiratory impedance response to a deep inhalation in asthmatic children with spontaneous airway obstruction
Authors: C. Schweitzer, C. Moreau-Colson, F. Marchal
Journal: European Respiratory Journal (1999)

Previous reports suggest that regular use of beta-agonists does not lead to tolerance to their bronchodilator effects. However, most studies have been conducted in stable asthma. This study investigates whether bronchodilator tolerance can be demonstrated during acute bronchoconstriction. Thirty-four asthmatic subjects were treated with 6 weeks inhaled terbutaline (1 mg q.i.d.), budesonide (400 microg, b.i.d.), both drugs or placebo in a randomized, double-blind, cross-over study. After each treatment methacholine was administered to induce a 20% fall in the forced expiratory volume in one second (FEV1). The response to inhaled salbutamol 100, 100, 200 microg at 5 min intervals) was then measured. Dose-response curves were compared using an analysis of covariance. Pre-methacholine FEV1, the highest pre-methacholine FEV1, the fall in FEV1 induced by methacholine and the logarithm of the provocative dose of methacholine required to induce the 20% fall in FEV1 (PD20) were used as covariates. There was a significantly reduced response to salbutamol after 6 weeks terbutaline treatment: the mean (95% confidence intervals (CI)) area under the dose-response curve was reduced by 36% (24, 47) compared to placebo (p&lt;0.0001). The reduction in bronchodilator response was not affected by concomitant treatment with budesonide. Significant tolerance to the bronchodilator effect of inhaled beta-agonists may be demonstrated when tested during acute bronchoconstriction. Continuous treatment with inhaled beta-agonists may lead to a reduced response to emergency beta-agonist treatment during asthma exacerbations.
Staff assessment of interns and residents
Authors: H. A. Towsley
Journal: JAMA (1966)

In reviewing the titles assigned to the discussants on the panels being presented this morning, one finds it difficult to believe that any other profession or skill subjects its members and potential members to such scrutiny in the analysis of competence. Medical school admission committees have tried to sort out those who qualify academically, morally, and ethically, whom they think are capable of becoming responsible for the health care of the people of our nations. With equal diligence, medical school faculties have weeded out those whose intellectual ability and concern for human dignity in health and disease do not measure up to a general set of standards by which physicians may be judged. Those of us who have been granted the privilege of providing graduate medical educational programs, internships, and residencies in either affiliated or nonaffiliated hospitals have an equal, if not greater, responsibility than admission committees and medical school
Radionuclide detection of diffuse interstitial pulmonary calcification
Authors: G. M. Grames
Journal: JAMA (1974)

Two patients who had hypercalcemia, one from multiple myeloma and the other from metastatic carcinoma, showed striking concentrations of bone-seeking radiopharmaceuticals in the lungs on routine bone scans. Neither patient had roentgenographic evidence of intrapulmonary calcification. Histologic examination in one patient showed extensive interstitial pulmonary calcification. These cases dramatically illustrate the capability of radionuclides to detect interstitial pulmonary calcification when radiographic demonstration is lacking. The early detection of extraskeletal calcification by bone-seeking radionuclides provides a unique opportunity, not previously available, to study metastatic calcification and the effects of treatment. (<i>JAMA</i>230:992-995, 1974)
Error in Table
Authors: Paul Christine, Ana Diez Roux
Journal: JAMA Internal Medicine (2015)

Estefanía Toledo, MD, MPH, PhD; Jordi Salas-Salvadó, MD, PhD; Carolina Donat-Vargas, PharmD; Pilar Buil-Cosiales, MD, PhD; Ramón Estruch, MD, PhD; Emilio Ros, MD, PhD; Dolores Corella, DPharm, PhD; Montserrat Fitó, PhD; Frank B. Hu, MD, PhD; Fernando Arós, MD, PhD; Enrique Gómez-Gracia, MD, PhD; Dora Romaguera, MSc, PhD; Manuel Ortega-Calvo, MD; Lluís Serra-Majem, MD, PhD; Xavier Pintó, MD, PhD; Helmut Schröder, PhD; Josep Basora, MD, PhD; José Vicente Sorlí, MD, PhD; Mònica Bulló, BSc, PhD; Merce Serra-Mir, RD; Miguel A. Martínez-González, MD
综合评估和分类防晒服的方法
Authors: N.J. Downs, S.L. Harrison
Journal: British Journal of Dermatology (2018)

Summary 过度暴露于阳光中会导致皮肤癌,这是人类最常见的癌症。在澳大利亚,约有80%的黑色素瘤(皮肤癌最致命的形式)病例可以通过减少阳光曝晒进行预防。衣服可以作为防护屏障,有效地减少到达皮肤的太阳紫外辐射(UVR)。1996年,澳大利亚的研究人员根据UVR穿透衣料的情况(称为紫外线防护系数(UPF))主导了一项衣服的防晒能力相对等级研究。UPF服装吊牌作为此项初始标准(AS/NZS 4399:1996)的一部分引入,这一做法被业界广泛采用。然而,这项研究并未考虑到服装覆盖的人体皮肤表面积(BSA)。一些标准(例如欧盟,2003年;澳大利亚/新西兰,2017年)中加入了对躯体和四肢的最低身体覆盖面积要求,而其他标准(例如美国)则未有改动。鉴于有最新证据表明,衣服覆盖对预防在幼年时期形成的色素痣(黑色素瘤的重要风险因素)起着重要的作用,因此,防晒服评级方案除了考虑衣料UPF之外,还必须考虑服装的BSA覆盖面积。我们开发了一项用于评级防晒服的新指标“服装防护系数(GPF)”,其中包含了上述两项重要因素。BSA覆盖面积是通过比较穿衣服和未穿衣服的模特身上可见的线条数量决定的。GPF随着服装的BSA覆盖面积和衣料UPF的增加而提高,共分为3个类别:GPF 0至&amp;lt; 3,表示此类服装“满足”最低标准;3至&amp;lt; 6,表明此类服装拥有“良好”的防晒能力;而GPF ≥ 6,则表明防晒能力“出色”。采用这种评级方案有助于鼓励制造商设计超出BSA覆盖面积和衣料UPF的最低标准的防晒服装,并为消费者提供充足的信息进行选择,从而有效的预防皮肤癌。
Directions for Laboratory Work in Bacteriology.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Verrucae by Bismuth Sodium Tartrate
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect on exophthalmos of various methods of treatment of Graves' disease
Authors: G. Gwinup
Journal: JAMA (1982)

Patients with both exophthalmos and hyperthyroidism were treated with different modes of therapy for their hyperthyroidism. Propylthiouracil followed by surgery, propylthiouracil followed by radioactive iodine, propylthiouracil alone, and radioactive iodine alone were used. Some of the patients became hypothyroid and were made euthyroid with levothyroxine sodium. Based on the mode of therapy and whether or not hypothyroidism occurred, each patient was assigned to one of seven groups and followed up for 18 months or longer. Careful exophthalmometry was performed at six-week intervals in all patients. Though progression of exophthalmos was noted in all groups, the group that received propylthiouracil demonstrated the greatest progression of exophthalmos. In the group receiving sodium iodide I 131 therapy and in the group treated surgically, the rate of progression of exophthalmos was lessened with the development of hypothyroidism. Since these hypothyroid patients were made euthyroid with supplemental levothyroxine, it appeared that loss of thyroid tissue, rather than the hypothyroidism per se, was responsible for the decrease in progression of the exophthalmos. The continued progression of exophthalmos in the propylthiouracil-treated group may be related to effects of propylthiouracil on the immune system. (<i>JAMA</i>1982;247:2135-2138)
First International Symposium on Recent Advances in Tumor Immunology
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article First International Symposium on Recent Advances in Tumor Immunology Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 4, April 1984, Page 963, https://doi.org/10.1093/jnci/72.4.963 Published: 01 April 1984
Experimental Identification of Chemical Carcinogens, Risk Evaluation, and Animal-to-Human Correlations
Authors: Umberto Saffiotti
Journal: Environmental Health Perspectives (1978)

Experimental methods for the identification of chemical carcinogens have been extensively developed, including animal bioassay methods, animal models for cancer induction at major organ sites, models for the study of the effects of carcinogens in cells and tissues in culture and methods for the study of molecular events (metabolic activation, binding and detoxification of carcinogens; DNA damage and repair; mutagenicity). Current sources of documentation on carcinogenicity data are reviewed. The number of "known carcinogens" will vary considerably, depending on the criteria adopted for accepting evidence of carcinogenicity. Criteria for the evaluation of risks, benefits, and technological alternatives for public policy on environmental carcinogens are reviewed and the following steps discussed: registration of environmental chemical carcinogens and their uses; risk evaluation (considering sources, adequacy, quality and limits of the evidence; quantitative dose–response extrapolation within the same biological system; and species and model conversion factors); benefits evaluation; analysis of technological alternatives; comparative judgment and decision; open public documentation. The problem of animal-to-human correlations is considered, particularly for respiratory carcinogenesis. A laboratory approach is reviewed which includes: development and study of whole animal models for carcinogenesis, analysis of animal tissue responses to carcinogens in vivo and through in vitro culture methods for morphological and biochemical studies, and development of in vitro culture methods for human target tissues. This approach is aimed at providing an experimentally controlled and quantifiable method for the correlation of animal and human observations in carcinogenesis.
Antoni van Leeuwenhoek on the circulation of the blood. Latin text of his 65th letter to the Royal Society (Sept. 7th 1688). Facsimile.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Technique of Controlled Drug Assay: III. Comparison of Guanethidine, Mecamylamine, and a Placebo
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A System of Practical Therapeutics
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Birth weight among women of different ethnic groups
Authors: P. H. Shiono
Journal: JAMA (1986)

Differences in mean birth weight and low birth weight (&lt;2.5 kg) are analyzed among Asians, blacks, Hispanics, and whites who were enrolled in the Northern California Kaiser-Permanente Birth Defects Study, a prospective study of 29,415 pregnancy outcomes. Large differences in birth weight among babies of different ethnic groups persist after controlling for the joint effects of maternal smoking and alcohol use during pregnancy, sex of child, parity, length of prenatal care, and maternal weight-for-height percentile. Compared with whites, the relative mean differences in birth weight are estimated as —246 g for blacks, —210 g for Asians, —105 g for Hispanics, and —140 g for others. The low-birth-weight rates and crude odds ratios are 7.70% (2.17) for blacks; 5.57% (1.57) for Asians; 5.52% (1.55) for others; 4.00% (1.13) for Hispanics; and 3.55% (1.00) for whites. After controlling for the effects of 22 factors, the odds ratios for a low-birth-weight infant are 2.41 for blacks, 1.37 for Asians, 1.93 for others, and 1.25 for Hispanics. It is concluded that factors currently used to control for ethnic differences in birth weight are insufficient to explain the observed differences. (<i>JAMA</i>1986;255:48-52)
Abstract P3-05-05: Class IIa HDAC inhibition promotes an anti-tumor macrophage phenotype that induces breast tumor regression and inhibits metastasis
Authors: JL Guerriero, A Sotayo, HE Ponichtera, JA Castrillon, AL Pourzia, S Schad, SF Johnson, RD Carrasco, S Lazo, RT Bronson, SP Davis, M Lobera, MA Nolan, A Letai
Journal: Cancer Research (2018)

Abstract While tumor-associated macrophages (TAMs) often have net pro-tumor effects, their embedded location and their untapped potential provide impetus to the discovery of strategies to turn them against tumors. We recently reported that a first in class selective class IIa HDAC inhibitor (TMP195) influenced human monocyte responses to colony stimulating factors CSF-1 and CSF-2 in vitro. Here, we utilize a macrophage-dependent autochthonous mouse model of breast cancer to demonstrate that in vivo TMP195 treatment alters the tumor microenvironment and reduces tumor burden and pulmonary metastases through macrophage modulation. TMP195 induces recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumors. Furthermore, combining TMP195 with chemotherapy regimens or T-cell checkpoint blockade in this model significantly enhances the durability of tumor reduction. These data introduce class IIa HDAC inhibition as a novel means to harness the anti-tumor potential of macrophages to enhance cancer therapy. Citation Format: Guerriero JL, Sotayo A, Ponichtera HE, Castrillon JA, Pourzia AL, Schad S, Johnson SF, Carrasco RD, Lazo S, Bronson RT, Davis SP, Lobera M, Nolan MA, Letai A. Class IIa HDAC inhibition promotes an anti-tumor macrophage phenotype that induces breast tumor regression and inhibits metastasis [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P3-05-05.
Abstract 776: Posttransriptional control of steroid biosynthesis pathway in prostate cancer
Authors: Asmita Bhattarai, Girish C. Shukla
Journal: Cancer Research (2019)

Abstract Prostate cancer (PCa) depends on androgens for growth and maintenance. Despite curative therapeutics of the androgen-sensitive PCa, one-third of patients relapse to a more aggressive form of the disease known as castration-resistant PCa (CRPC). Androgen signaling mediated via Androgen receptor (AR) continues to promote CRPC and therapeutic resistance. The synthesis of testosterone (T) and dihydrotestosterone (DHT) via Intratumoral steroidogenesis appears to play a crucial role in CRPC. It appears that PCa cells synthesize de-novo androgen from cholesterol from acetyl-coA via Terpenoid backbone and Steroid biosynthesis pathways. We found that several enzymes of the intracellular cholesterol synthesis pathways including HMGS1, HMGCR, SREBP1, FASN, SCARB1 are potential targets of hsa-miR-149 5p. Currently, we are characterizing miR-149-5p mediated posttranscriptional regulation of these genes and determining its potential therapeutic application in CRPC. Citation Format: Asmita Bhattarai, Girish C. Shukla. Posttransriptional control of steroid biosynthesis pathway in prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 776.
Vitamin D Insufficiency and Prognosis In Chronic Lymphocytic Leukemia (CLL)
Authors: Tait Shanafelt, Matthew Drake, Matthew Mauer, Cristine Allmer, Kari Rabe, Susan Slager, George Weiner, Timothy Call, Brian Link, Clive S. Zent, Neil E. Kay, Curtis Hanson, Thomas E. Witzig, James Cerhan
Journal: Blood (2010)