tbuckley/cabot-search huggingface dataset:
A Sensitive Zonagenetic Assay for Rapid in Vitro Assessment of Estrogenic Potency of Xenobiotics and Mycotoxins
Authors: Trine Celius, Trine B. Haugen, Tom Grotmol, Bernt T. Walther
Journal: Environmental Health Perspectives (1999)

Mounting evidence confirms that hepatic biosynthetic processes are essential for female sexual maturation in fish, which is directly controlled by estrogens. These oogenetic events (zonagenesis and vitellogenesis) are induced in both sexes by estrogens. In this paper, we report the induction of zona radiata (zr) proteins and vitellogenin in primary hepatocytes from Atlantic salmon (Salmo salar L.) exposed to xenoestrogens and mycotoxins. Cells were treated with doses of 1, 5, and 10 microM 4-nonylphenol (4-NP), o, p'-DDT, lindane ([gamma]-HCH), and bisphenol A (BPA), which all induced zr proteins and vitellogenin in an approximate dose-dependent manner. Hepatocytes were also treated with combinations of xenoestrogens at 1 or 2 microM, resulting in elevated levels of both zr proteins and vitellogenin, compared to single treatment. The estrogenic activity of the mycotoxin zearalenone (ZEA) and its metabolites [alpha]-ZEA) and ss-zearalenol (ss-ZEA)], with regard to zonagenesis and vitellogenesis, was assessed in this assay system. Mycotoxins were used at concentrations of 10, 100, or 1,000 nM. All induced zr proteins and vitellogenin, with [alpha]-ZEA being the strongest inducer. When cells were treated with xenoestrogens or mycotoxins in combination with an estrogen receptor inhibitor (ICI 182,780), the induction of both zr proteins and vitellogenin was inhibited in all cases. Thus, the reported estrogen effects are bonafide estrogen responses. Zona radiata proteins were more responsive than vitellogenin to both xenoestrogens and mycotoxins. The versatility and sensitivity of the hepatocyte assay demonstrates that biosynthesis of zr proteins provides a new supplementary method for estimating xenoestrogenicity and mycotoxin action.
Single injection of antigen-specific regulatory Tr1 lymphocytes protects mice from severe collagen-induced arthritis
Authors: D Martire, A-L Bonnefont, H Asnagli, N Belmonte, M Jourdin-Boucard, S Rouquier, A Mantello, P B Fall, A Foussat, C Jorgensen, P Louis-Plence
Journal: Annals of the Rheumatic Diseases (2010)
Histaminuria in Mastocytosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Weight loss in amateur wrestlers and its effect on serum testosterone levels
Authors: R. H. Strauss
Journal: JAMA (1985)

Levels of nine serum hormones, six skin-fold sites, and body weight were measured in 19 male amateur wrestlers during their competitive season and again two months after the season. Percent of body fat was estimated from skin-fold thicknesses. Body weight, body fat, testosterone level, and prolactin level were significantly lower during the wrestling season. Low serum testosterone levels were significantly correlated with low body fat, large loss of body fat, and large weight loss. These findings suggest that the dietary restriction practiced by some wrestlers may affect serum testosterone levels adversely. (<i>JAMA</i>1985;254:3337-3338)
Pomalidomide Plus Low-Dose Dexamethasone In Myeloma Refractory to Both Bortezomib and Lenalidomide: Comparison of Two Dosing Strategies In Dual-Refractory Disease
Authors: Martha Lacy, Sumithra Mandrekar, Morie Abraham A Gertz, Suzanne R. Hayman, Kristen Detweiler Short, Francis Buadi, Angela Dispenzieri, Shaji Kumar, Steven Zeldenrust, David Dingli, Philip R. Greipp, John Lust, Stephen Russell, Robert Kyle, Rafael Fonseca, P. Leif Bergsagel, Vivek Roy, A. Keith Stewart, Jacob Allred, Kristina Laumann, Craig B. Reeder, S. Vincent Rajkumar, Joseph R. Mikhael
Journal: Blood (2010)
A HORMONE OF THE SUPRARENAL CORTEX
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE NOMENCLATURE OF SYNTHETIC MEDICINES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THURSDAY 14TH SEPTEMBER
Journal: Gut (1995)

Proteolytic degradation of the basement membrane allowing tumour cell invasion is an important process in the development of metastases.The conversion of plasminogen to the active protease plasmin by urokinase plasminogen activator is thought to be a key step in initiating proteolysis.This process was investigated in human oesophageal and gastric carcinoma cell lines using an in vitro invasion model.Isotope-labelled subendothelial cell basement membranes were prepared by incubating human umbilical vein endothelial cells in the presence of [3H]serine (5pCi/ml).Two oesophageal (KYSE 140, KYSE 30) and two gastric (AGS, HGC-27) carcinoma cell lines were seeded onto the membranes and grown in the presence or absence of plasminogen (40tg/ml).Degradation was deternined by the measurement of activity released into the supematant at 24hr intervals. (Results are shown as median counts per minute.)
Medical Economics and Miscellany
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhanced neutrophil response in chronic obstructive pulmonary disease
Authors: A Noguera, S Batle, C Miralles, J Iglesias, X Busquets, W MacNee, A G N Agustí
Journal: Thorax (2001)

BACKGROUND Neutrophils are likely to play a major role in the inflammatory response seen in chronic obstructive pulmonary disease (COPD). This study sought to address the hypothesis that an enhanced neutrophil response to proinflammatory agents in COPD may contribute to their recruitment and activation in the lungs. METHODS Circulating neutrophils were obtained from 10 patients with COPD, eight long term smokers with normal lung function, and eight healthy never smoking controls. The in vitro production of reactive oxygen species (ROS) was measured by the NADPH oxidase method (respiratory burst) and the surface expression of several adhesion molecules (Mac-1, LFA-1 and l -selectin) was measured by flow cytometry. Measurements were obtained under basal conditions and after stimulation with phorbol myristate acetate (PMA) and tumour necrosis factor alpha (TNFα). mRNA levels of p22- phox (a subunit of NADPH oxidase) and Mac-1 (CD11b) were also determined by reverse transcriptase polymerase chain reaction (RT-PCR). RESULTS Patients with COPD showed enhanced respiratory burst compared with smokers with normal lung function, both under basal conditions (mean (SE) fluorescence intensity (MFI) 15.1 (0.5) v 11.6 (0.5); mean difference –3.4 (95% CI of the difference –5.1 to –1.8), p&lt;0.01) and after PMA stimulation (MFI 210 (7) v 133 (10); mean difference –77 (95% CI of the difference –102 to –52), p&lt;0.01). Mac-1 surface expression was also enhanced in patients with COPD, both under basal conditions (MFI 91 (5) v 45 (3); mean difference –46 (95% CI of the difference –61 to –31), p&lt;0.001) and after stimulation with TNFα (MFI 340 (15) v 263 (11); mean difference –77 (95% CI of the difference –119 to –34), p=0.001). These differences were also apparent when patients with COPD were compared with non-smokers (p&lt;0.05). The mRNA levels of p22- phox and Mac-1 (CD11b) were similar in patients with COPD and smokers with normal lung function, suggesting that the observed differences were due to post-transcriptional regulation. CONCLUSIONS These results demonstrate an enhanced neutrophil response to proinflammatory agents in patients with COPD which may contribute to their enhanced recruitment and activation in the lungs of these patients. These findings support those of other studies which have indicated that the neutrophil is likely to play a major role in the pathogenesis of this disease.
Notes and news
Authors: Tore Nilson, Maarten Boers
Journal: Annals of the Rheumatic Diseases (1992)

Outcome measures in rheumatoid arthritis clinical trials A conference on outcome measures in rheumatoid arthritis clinical trials will be held in Maastricht, The Netherlands from 29 April to 3 May 1992.Cost 2000 Dutch guilders (approximately $1200).It will consist of small group dis- cussions using the nominal group technique.
BILE PIGMENT AS AN EXPRESSION OF BLOOD DESTRUCTION
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I study of azacitidine, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer (CRPC) previously treated with docetaxel-based therapy.
Authors: R. Singal, K. Ramachandran, E. Gordian, I. M. Reis, W. Zhao, C. A. Quintero, C. Mayo, F. Auguste
Journal: Journal of Clinical Oncology (2010)

e13563
Cytologic Diagnosis of Cytomegalic Inclusion-Body Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts
Journal: Annals of the Rheumatic Diseases (1956)

The importance of joint pain as a manifestation of rheumatic fever was evaluated in 648 consecutive patients under the age of 17 admitted to the House of the Good Samaritan (Harvard Medical School), Boston, between 1943 and 1948; cases of chorea were excluded from the study.On the criteria adopted (objective signs in two or more joints) significant arthritis was present in 50 per cent. of the patients, and of these joint pain was the presenting symptom in 94 per cent., while cardiac involvement occurred in 50 per cent.The distribution of the antistreptolysin-O titres was studied in each of four clinical groups in order to deter- mine its value in differentiating the joint pain due to rheumatic fever from that due to other diseases.The patients with rheumatic fever were divided into two groups:(1) 208 patients with definite rheumatic carditis;(2) 227 patients with definite rheumatic fever and arthritis.In these two groups the antistreptolysin-O titres showed a similar distribution, namely, 400 units or more in 82 per cent. of Group 1 and in 85 per cent. of Group 2, and 159 units or less in 3 and 1 * 8 per cent.respectively.(3) 75 cases of juvenile rheumatoid arthritis.The titre was 400 units or more in 28 per cent.and 159 units or less in 56 per cent.(4) 92 patients with miscellaneous diseases of which joint pain was a prominent feature, showed a titre of 400 units or more in 8 per cent.and one of 159 units or less in 59 8 per cent.It is concluded that joint pain is a frequent, early, and important manifestation of rheumatic fever, and that, while a high antistreptolysin-O titre is consistent with, but not diagnostic of, rheumatic fever, a very low titre may be regarded as excluding active rheumatic fever.J gr. per lb. (70mg. per kg.) body weight daily).In- jections of penicillin or sulphonamides were given prophylactically in all cases, and the hormone-treated '73 copyright.
Dennis L. Breo's Reply
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Purulent pericarditis and mediastinitis due to Peptococcus magnus
Authors: R. Phelps
Journal: JAMA (1985)

PURULENT pericarditis and atraumatic mediastinitis are both uncommon illnesses. We report herein a case with both infections due to<i>Peptococcus magnus</i>, a pathogen reported only rarely<sup>1,2</sup>as the cause of either infection. The source of infection was probably an occult tooth abscess. <h3>Report of a Case</h3> A 30-year-old man was admitted elsewhere after two weeks of progressive fever, pleuritic chest pain, cough, and dyspnea. Examination disclosed fever and findings of pericardial tamponade. A chest roentgenogram showed cardiomegaly, and an echocardiogram showed normal valves and a large pericardial effusion. Pericardiocentesis was performed, with removal of 10 mL of purulent fluid. Examination of the fluid revealed 67,000 white blood cells (89% polymorphonuclear leukocytes) and gram-positive cocci. Blood cultures were not obtained. Therapy with nafcillin sodium and tobramycin was begun, and clindamycin was added when only anaerobic cultures yielded organisms. Biochemical identification of the pathogen as<i>P magnus</i>and persistent fever prompted
Phase 1 Study Update of the Novel Pan-Pim Kinase Inhibitor LGH447 in Patients with Relapsed/ Refractory Multiple Myeloma
Authors: Marc S Raab, Enrique M Ocio, Sheeba K. Thomas, Andreas Günther, Yeow-Tee Goh, Daniel Lebovic, Andrzej Jakubowiak, Dongweon Song, F Xiang, Apurva Patel, K. Gary Vanasse, Shaji Kumar
Journal: Blood (2014)
Author Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells
Authors: Nipun Verma, Heng Pan, Louis C. Doré, Abhijit Shukla, Qing V. Li, Bobbie Pelham-Webb, Virginia Teijeiro, Federico González, Andrei Krivtsov, Chan-Jung Chang, Eirini P. Papapetrou, Chuan He, Olivier Elemento, Danwei Huangfu
Journal: Nature Genetics (2017)
Our Time: A Call to Save Preventable Death From Cardiovascular Disease (Heart Disease and Stroke)
Authors: Sidney C. Smith, Amy Collins, Roberto Ferrari, David R. Holmes, Susanne Logstrup, Diana Vaca McGhie, Johanna Ralston, Ralph L. Sacco, Hans Stam, Kathryn Taubert, David A. Wood, William A. Zoghbi
Journal: Journal of the American College of Cardiology (2012)
Industrial Exhibitors
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction:<i>2016 American college of rheumatology/European league against rheumatism criteria for minimal moderate, and major clinical response in juvenile dermatomyositis</i>
Authors: Lucy Matthews, Hannah Maclaren, John Loughlin, Nigel Arden, Fraser Birrell, Andrew Carr, Panos Deloukas, Michael Doherty, Andrew Mccaskie, William E R Ollier, Ashok, D Spector, Ana Valdes, Gillian Wallis, Jeremy Wilkinson
Journal: Annals of the Rheumatic Diseases (2018)

The enzyme range was calculated based on a 90% range of enzymes from natural history data (5,38), which for creatine kinase is 20 times the upper limit of normal (ULN), for aldolase is 6 times the ULN, and for lactate dehydrogenase, aspartate aminotransferase, and alanine transaminase is 5 times the ULN.
Treatment of detainees in South Africa
Authors: M. E Bennun
Journal: BMJ (1983)

20 30 4O 50 60 70 Time (months) FIG 2-Survival curves from the British (MRC working party (ref 1)) and American (Nocturnal Oxygen Therapy Trial Group (ref 12)) trials for men under the age of 70 receiving oxygen for more than 19 hours (COT), 12 hours (NOT), or 15 hours (MRC 02) in the 24 hour day or not receiving oxygen (MRC controls).I thank Dr T L Petty for providing this data from the NOTT study.indicate that this treatment is worth considering for such carefully selected patients.Research efforts should now be directed to how to provide this treatment most economically and at most convenience to the patients, and how to improve selection of those most likely to benefit.'3I submit that this treatment is indeed based on sound scientific considerations and that the economic case may be best considered in light of existing expenditure on home oxygen treatment, where, I suspect, current clinical practice is much more in need of critical appraisal.