tbuckley/cabot-search huggingface dataset:
Gene-based prediction of PSA recurrence for clinically localized prostate cancer patients
Authors: D. Talantov, T. Jatkoe, M. Bohm, Y. Zhang, P. Stricker, M. W. Kattan, R. L. Sutherland, J. G. Kench, Y. Wang, S. Henshall
Journal: Journal of Clinical Oncology (2009)

5132 Background: Accurate estimates of the risk of recurrence are needed for the optimal management of patients with clinically localized prostate cancer. We combined an established nomogram and novel molecular predictors into a new prognostic model of prostate specific antigen (PSA) recurrence. Methods: Gene expression profiles from formalin-fixed, paraffin-embedded (FFPE) localized prostate cancer tissues were analysed to identify genes associated with PSA recurrence. The profiles of the identified markers were reproduced by reverse-transcriptase-polymerase-chain-reaction (RTPCR). The RTPCR profiles from 3 of these genes, along with the output from the Kattan post-operative nomogram, were used to produce a predictive model of PSA recurrence. Results: After variable selection, a model of PSA recurrence was built that combined expression values of 3 genes and the postoperative nomogram. The 3-gene plus nomogram model predicted 5-year PSA recurrence with a concordance index (c-index) of 0.77 in a validation set compared to a c-index of 0.67 for the nomogram. This model identified a subgroup of patients that were at high risk for recurrence which were not identified by the nomogram. Conclusions: This new gene-based classifier has superior predictive power when compared against the 5-year nomogram to assess risk of PSA recurrence in patients with organ-confined prostate cancer. Our classifier should provide a more accurate stratification of patients into high and low risk groups for treatment decisions and adjuvant clinical trials. [Table: see text]
Multiphasic Screening
Authors: C. H. Altshuler
Journal: JAMA (1972)

<h3>To the Editor.—</h3> "The Yield of Multiphasic Screening," by Bates and Yellin (222:74,1972) defines several of the difficulties in multiphasic screening programs. Some of the problems might be circumvented by combining the multiphasic screen with the Pali (programmed accelerated laboratory investigation) and the Slic (selected laboratory information center) systems recently described. (<i>CRC Crit Rev Clin Lab Sci</i>3:379, 1972). The Pali provides for a pathologistdirected follow-up laboratory investigation, and the Slic, on microfiche, provides some of the necessary interpretative information for the physician. Our pertinent experience with the Pali has shown that it is economically and technically feasible, makes efficient use of the patient's serum and urine, is suitable for screening "normal" individuals, is of value in establishing normal values, facilitates interpretation of the laboratory data, and minimizes iatrogenic illness of laboratory origin. Our pertinent experience with the Slic has shown that the system provides a comprehensive data bank for
Highlights
Journal: JAMA Pediatrics (2019)

Obesity in Children of Mothers With Gestational Diabetes 424Faith and colleagues conducted a cohort study of children who were born to mothers with gestational diabetes.Compared with those with nonelevated soothability, infants with elevated soothability had more than a 2-fold increased adjusted odds of childhood obesity at ages 2 to 5 years after controlling for numerous potential confounders.
The opening sentence
Authors: L. S. King
Journal: JAMA (1967)

In any writing the opening sentence has a heavy responsibility. It must seize the reader's attention and make him want to continue, indicate the general subject matter, and impart its information in a pleasing and attractive form. Students in journalism courses are taught a formula for writing the opening sentence—the who-where-when-what-how approach. This will tell who did what, where and when he did it, and will give whatever attendant circumstances can fit into a single sentence. But medical writing is different from a newspaper report. The first sentence has a dual function: it must carry some essential information, particularly the problem under consideration, and at the same time gently translate the reader into the body of the article. There is no need to crowd all the specific information that the news reporter tries to express, nor yet to provide a setting or background such as a short story writer might
Outlines of Psychiatry.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nursing manpower.
Authors: N Bosanquet
Journal: BMJ (1987)

these figures are favourably influenced by the deaths of high risk patients.If a patient ruptures his aneurysm and reaches hospital alive early diagnosis and an immediate operation are vital.With a non-operative mortality of 100% there is little need for debate or delay.The patient should be anaesthetised on the operating table after all preparations for the operation are complete.The relaxation of the abdominal muscles may result in the rupture extending and dramatic hypotension.Early proximal control of the aneurysm is important, and catheters have been used before the patient is anaesthetised.i'Interventional radiology may have an increasingly important place if it does not delay the operation.Many deaths occur in patients who are moribund when they present, and medical ingenuity cannot help.The opportunity for improving results must lie in diagnosis before rupture, and in an ideal world a screening programme could be employed using ultrasonography or, better still, nuclear magnetic resonance.Necropsy studies suggest that three elective resections would be needed to avert one rupture.'Such a programme would need 12 000 operations in England and Wales5' and cost £9000 for each life saved."2In the United States the cost might be $10 billion.22More realistically, doctors must become more aware of abdominal aneurysms and palpate the abdomen of men over 50, just as they would take their blood pressure.Ultrasonography should then be used in doubtful cases and those with other cardiovascular symptoms.
Influenza Activity—United States and Worldwide, and Composition of the 1993-94 Influenza Vaccine
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Joyful jogging
Authors: S. Vaisrub
Journal: JAMA (1978)

Adult ambulation used to puzzle children. Why do grown-ups plod along leisurely when running is so much more fun? With the current jogging vogue, this perplexity no longer exists. Now a child is more apt to wonder why adults are so eager to run when they can be comfortably watching television. Jogging owes much of its current popularity to the changing therapeutic approaches to coronary heart disease. Whereas but a short time ago myocardial infarction was a prelude to a lifelong restriction of physical activity, it now serves as a signal for exercise programs, with jogging playing a prominent part. Underlying this changing trend in therapy is the assumption, based on animal experiments, that exercise stimulates the development of intercoronary collateral circulation and thus improves left ventricular function and prolongs life expectancy. How valid is this assumption? Nolewajka and associates<sup>1</sup>conducted a study on 17 men convalescing from acute
NITROGLYCERIN HEAD
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interstitial high dose rate (HDR) brachytherapy + IMRT vs. HDR monotherapy for early stage prostate cancer
Authors: R. Mark, G. Vallabhan, P. Anderson, T. Neumann, R. Akins, M. Nair
Journal: Journal of Clinical Oncology (2005)

4718 Background: Transrectal Ultrasound (TRUS) guided interstitial implant for prostate cancer using High Dose Rate (HDR) + External Beam Radiation Therapy (EBRT) technique has been reported with favorable results. We have questioned the role of EBRT. We compare our results of HDR + IMRT vs. HDR alone. Methods: Between 1997 and 2004, 246 patients with T1 and T2 localized prostate underwent TRUS guided interstitial implant. There were no Gleason Score or PSA exclusions. At last follow-up, 109 patients elected HDR Implant + IMRT and 137 patients underwent HDR monotherapy. No patient received Hormonal Blockade. Median Gleason Score was 7 (range: 4 to 10). Median PSA was 9.8 (0.60 to 39.8). In patients who received IMRT + HDR, 4500 cGy in 25 fractions was given via IMRT and 1650 cGy in 3 fractions via HDR. Our HDR protocol called for two HDR Implants, spaced 4 weeks apart. The treatment volume received 2,250 cGy in 3 fractions prescribed to the 100% Isodose line, given over 24 hours. A 2nd implant was performed 4 weeks later, delivering a further 2,250 cGy in 3 fractions, bringing the final dose to the prostate to 4,500 cGy in 6 fractions. Results: The groups were comparable with respect to T-Stage, Gleason Score, and PSA. The median follow-up was 54 months (6–92 months). In patients undergoing IMRT + HDR Implant, PSA disease free survival was 89.9% (98/109) vs. 91.9% (126/137) for patients undergoing HDR alone (p=0.6). The 5 year actuarial survival was 86% for the group receiving IMRT + HDR vs. 89% with HDR monotherapy (log rank = 0.5). Urethral stricture developed in 2.8% (7/246), and urinary stress incontinence in 0.8% (2/246). RTOG late bladder toxicities were: 0% Grade 4, 0% Grade 3, and 3.3% (8/246) Grade 2. RTOG late rectal toxicities were: 0.4% (1/246) Grade 4, 0% Grade 3, 3.7% (9/246) Grade 2, and 4.9% (12/246) Grade 1. RTOG late rectal toxicity was higher in patients undergoing HDR + IMRT with 14.7% (16/109) of patients experiencing Grade 2 and 1 symptoms, vs. 3.6% (5/137) receiving HDR alone. Conclusions: We have observed no significant difference in PSA disease free survival or complications in patients undergoing HDR vs. HDR + IMRT. By omitting EBRT, rectal complications may be reduced. No significant financial relationships to disclose.
Book Review Effects of Alcohol on the Individual: A critical exposition of present knowledge. Volume 1. Alcohol Addiction and Chronic Alcoholism . Edited on behalf of the Scientific Committee of the Research Council on Problems of Alcohol by E. M. Jelhnek, Sc.D. 8°, cloth, 336 pp., with 43 tables and 5 figures. New Haven: Yale University Press, 1942. $4.00.
Journal: New England Journal of Medicine (1943)
Some Reactions and Properties of Nitro Radical-Anions Important in Biology and Medicine
Authors: Peter Wardman
Journal: Environmental Health Perspectives (1985)

Nitroaromatic compounds, ArNO2 have widespread actual or potential use in medicine and cancer therapy. There is direct proof that free-radical metabolites are involved in many applications, and an appreciation of the conceptual basis for their therapeutic differential; however, an understanding of the detailed mechanisms involved is lacking. Redox properties control most biological responses of nitro compounds, and the characteristics of the one-electron couple: ArNO2/ArNO2- are detailed. The "futile metabolism" of nitroaryl compounds characteristic of most aerobic nitroreductase systems reflects competition between natural radical-decay pathways and a one-electron transfer reaction to yield superoxide ion, O2-. Prototropic properties control the rate of radical decay, and redox properties control the rate of electron transfer to O2 or other acceptors. There are clear parallels in the chemistry of ArNO2- and O2-. While nitro radicals have frequently been invoked as damaging species, they are very unreactive (except as simple reductants). It seems likely that reductive metabolism of nitroaryl compounds, although generally involving nitro radical-anions as obligate intermediates (and this is required for therapeutic selectivity towards anaerobes), results in biological damage via reductive metabolites of higher reduction order than the one-electron product.
PHYSICAL TRAINING IN THE ARMY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver disease progression and clinical outcomes in hepatic outcomes and survival fatty liver registry (HOTSURFR) study
Authors: Blaise Kutala, Jerome Boursier, Mattias Ekstedt, Hannes Hagström, Raluca Pais, Elisabetta Bugianesi, Jacob George, Jörn M. Schattenberg, Quentin Anstee, Pierre Bedossa, Vlad Ratziu
Journal: Journal of Hepatology (2020)
Canadian Psychiat Assoc Journal, Ottawa
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Borne
Authors: Sylvia S. Villarreal
Journal: Annals of Internal Medicine (2021)

Ad LibitumOctober 2021BorneSylvia S. Villarreal, MEd, MPHSylvia S. Villarreal, MEd, MPHMcGovern Center for Humanities and Ethics, Houston, TexasSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-6399 Audio Reading - “Borne” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “Borne” by Sylvia S. Villarreal, MEd, MPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the gathering silk of night, we turninto our driveway. After two weekshalf the nation away, our new status as grandparentsstill flutters in our minds. We held the futurein our arms—man-child with soft brown eyes.Perched on the wooden fencepost, a small screech owlsits very still, holding us in a deliberate stare.We startle, enthralled by this feathered visitorTo our tight-plotted livesnow stretched, expanded.This tiny owl's complete attention takes usback to the newborn's wriggling limbs and unsteady gaze,his eagerness to track faces, voices. To join us.What revelations will you bring us, little one?What wild, wondrous flights? Author, Article, and Disclosure InformationAffiliations: McGovern Center for Humanities and Ethics, Houston, TexasCurrent Author Address: Sylvia S. Villarreal, MEd, MPH, 6431 Fannin Street, Suite JJL 410, Houston, TX 77030; e-mail, Sylvia.S.[email protected]tmc.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Borne” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “Borne” by Sylvia S. Villarreal, MEd, MPH Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics October 2021Volume 174, Issue 10Page: 1491 ePublished: 19 October 2021 Issue Published: October 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Licorice and hypertension
Authors: L. Pelner
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The FDA's new procedures for the use of investigational drugs in treatment
Authors: F. E. Young
Journal: JAMA (1988)

The Food and Drug Administration has established new procedures to make promising investigational drugs available for treatment of patients with immediately life-threatening or serious diseases as early in the drug development process as possible and well before general marketing begins. The purpose of this article is to inform the medical community about these new procedures and to facilitate their implementation. Examples of immediately life-threatening and serious diseases are given and the procedures that physicians should use to obtain a drug under the new regulations are described. The treatment use of zidovudine (Retrovir), while still in the investigational phase, is described as a case study. The article also summarizes the Food and Drug Administration's new procedures under which drug sponsors can charge for investigational drugs. (<i>JAMA</i>1988;259:2267-2270)
Medical News &amp;amp; Perspectives
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal