tbuckley/cabot-search huggingface dataset:
Exposed
Authors: Scott Winner
Journal: Annals of Internal Medicine (2011)

On Being a Doctor5 April 2011ExposedScott Winner, MDScott Winner, MDFrom Penn State Milton S. Hershey Medical Center, Hershey, PA 17033-0850.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-7-201104050-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I pushed the needle further into her breast, positioned it directly behind her nipple, and injected the local anesthetic lidocaine.“Ouch!” she said.“Sorry. I know that hurts. The pain should fade quickly. You all right?”“Yeah. I'm OK.”“Good,” I said, relieved.Her cancerous left breast would be surgically removed in an hour. She was undergoing this preoperative procedure accompanied by three strangers. She had been given no medications to ease her anxiety. She concealed her fears.The technologist handed me a second syringe filled with a radioactive solution, and I inserted the needle into the patient's breast. The ... Author, Article, and Disclosure InformationAffiliations: From Penn State Milton S. Hershey Medical Center, Hershey, PA 17033-0850.Corresponding Author: Scott Winner, MD, Penn State Milton S. Hershey Medical Center, Department of Radiology, Mail Code H066, PO Box 850, 500 University Drive, Hershey, PA 17033-0850; e-mail, [email protected]psu.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVoices emerging from the shadows: Radiologic practitioners’ experiences of challenging conversations 5 April 2011Volume 154, Issue 7Page: 503-504KeywordsAnestheticsAnxietyDiagnostic radiologyEmotionsFearLymph nodesPediatricsSurgeonsSurgeryThorax ePublished: 5 April 2011 Issue Published: 5 April 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 1743: Evaluating the effect of USP22 depletion on chromosome instability in colorectal cancer
Authors: Lucile M. Jeusset, Kirk J. McManus
Journal: Cancer Research (2019)

Abstract Chromosome instability (CIN) is an aberrant phenotype defined as an increase in the rate at which whole chromosomes or large chromosomal fragments are gained or lost, and is observed in virtually all cancer types. Although CIN is associated with aggressive tumors, multi-drug resistance and poor patient prognosis, the genetic defects underlying CIN remain poorly understood. Preliminary data from our laboratory suggest that diminished USP22 (Ubiquitin-Specific Peptidase 22) expression induces CIN. Importantly, USP22 deletions and reduced USP22 expression are frequently observed in multiple cancer types, including colorectal cancer, suggesting diminished USP22 expression/function may be a pathogenic event underlying oncogenesis. Therefore, the present study seeks to evaluate the impact diminished USP22 expression has on CIN by determining whether karyotypically stable colorectal cancer (HCT116) and immortalized fibroblast (hTERT) cell lines can be converted into karyotypically unstable lines following the reduction of USP22 expression. Diminished USP22 expression was achieved by siRNA-based silencing or CRISPR-Cas9-mediated gene knockout (KO) and quantitative image-based single-cell analyses were employed to monitor changes in surrogate markers for CIN, including nuclear areas and chromosome numbers. USP22 silencing induced significant changes in nuclear area as well as increased frequencies of chromosomes gains and losses, which suggest USP22 is a CIN gene. Next, to assess the long-term impact diminished USP22 expression has on CIN, two HCT116 USP22-KO clones were monitored for 10 weeks and revealed dynamic changes in nuclear areas and chromosome numbers over time relative to controls. Collectively, these data identify USP22 as a novel CIN gene and indicate that USP22 deletions in cancer may have long-term impact on CIN and may thereby promote oncogenesis. Further analysis is ongoing to investigate the mechanism through which USP22 depletion induces CIN, and in particular its effect on H2B monoubiquitination. Characterizing the effect diminished USP22 expression has on CIN is the first step towards the development of therapeutic strategies targeting USP22-deficient cancers. Citation Format: Lucile M. Jeusset, Kirk J. McManus. Evaluating the effect of USP22 depletion on chromosome instability in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1743.
Upswing in Skin Cancer Costs
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inertia of left ventricular end-ejection flow speeds the propagation of left ventricular early diastolic filling flow Nobuyuki Ohte, Hitomi Narita, Sachie Akita, Kazuyuki Kurokawa, Norio Takada, Junichiro Hayano, Genjiro Kimura. Nagoya City University Medical School, Nagoya, Japan
Journal: Journal of the American College of Cardiology (2001)
Minerva
Journal: BMJ (1990)

VIEWS,"WThe list of inherited disorders for which the defective gene has been identified is growing ever longer, and geneticists in the United States are anxiously debating in which conditions some form of mass screening for carriers can be justified (Science 1990;247:17-9).The problems include the expense and the lack of "card carrying clinical geneticists" to provide the necessary expert counselling; the pressure comes from the fear that the lawyers are reading the journals too- and that it may not be too long before a doctor is sued for failing to offer a test.
A RECRUDESCENCE OF INFLUENZA.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of global protein-tyrosine phosphatase 1b-deficiency in gut barrier function during non-alcoholic steatohepatitis
Authors: Carmen Rubio, Marta Puerto, Juan J. García-Rodríguez, Van B. Lu, Irma García-Martínez, Rosa Alén, Luis Menchén Viso, Fiona Gribble, Frank Reimann, Luis G. Guijarro, José M. Carrascosa, Angela Martinez Valverde
Journal: Journal of Hepatology (2020)
Postexercise Peril
Authors: Michael I. Zucker
Journal: JAMA (1984)

<h3>To the Editor.—</h3> As a radiologist involved with nuclear medicine cardiac stress testing, I read with interest the article by Dimsdale et al.<sup>1</sup>However, as an amateur Greek historian, I must take exception to the alleged death of Pheidippides. The story of his death after running from Marathon to Athens has no historical basis. Pheidippides, a professional long-distance runner, was indeed mentioned by his contemporary, the Greek historian Herodotus.<sup>2</sup>The Athenians wished the aid of the Spartans in their war with the Persians but were unable to deliver a message to Sparta by sea because of ill-favored winds. Pheidippides was asked to run to Sparta to deliver the message. This he did, a nearly 150-mile run in just under two days. According to Herodotus, he arrived in good health and delivered an eloquent plea to the Spartans. There is no historical record of his death nor any evidence
THE GREGORY TESTIMONIAL BANQUET.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE BLOOD CALCIUM IN JAUNDICE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: BMJ (1856)

PUIC MEETING O0 DENTIST.On Tuesday, Nov. 1Ith, a numerously astended meeting of the members of the dental profession was held in the Freemnasons' Hall, Great Queen Street, Lincoln's Inn Fields, for the purpose of receiving the Report of the Committee appointed at a preliminary meeting held on the 22nd of September last at the London Tavern.Mr. Robinson, of Gower Street, Bedford Square, was called to the chair.The Cbairman explained that the object of the meeting was principally to form amongst the profession a Dental Institute.Mr. Rymer, the Secretary, read the Report, which stated, inter alia, that the Committee appointed at the previous maeeting had done all they could to carry out the resolutions of the last meeting.The rules for the inanagement of the insti- tution were then read.Mr. Mackenzie, the Chairmarn of Ihe
Baby Talks
Authors: Jiena Sun
Journal: Annals of Internal Medicine (2017)

Ad Libitum21 March 2017Baby TalksJiena Sun, PhDJiena Sun, PhDFrom Wuhan University, Hubei, China.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M17-0131 Audio Reading - “Baby Talks” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Baby Talks," by J. Sun. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “Did I have a Daddy when I was little?”“Yes.”“Where was Daddy then? Was he in the hospital?”“Yeah, taking care of sick babies.”“I don't like them.”“Why?”“Daddy took away my mother duck and gave her to a sick baby.”“No, he didn't. Your mother duck is right here. You just misplaced her.”“How often do you eat your chocolate?”... Author, Article, and Disclosure InformationAffiliations: From Wuhan University, Hubei, China.Current Author Address: Jiena Sun, PhD, English Department, School of Foreign Languages and Literature, Wuchang, Wuhan, Hubei, China 430072; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Baby Talks” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Baby Talks," by J. Sun. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 21 March 2017Volume 166, Issue 6Page: 448KeywordsChocolate ePublished: 21 March 2017 Issue Published: 21 March 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
New viral diseases. A real and potential problem without boundaries
Authors: E. D. Kilbourne
Journal: JAMA (1990)

Viruses are the most mutable and rapidly evolving human parasites. Therefore, it is not surprising that new virus diseases, such as the acquired immunodeficiency syndrome, are emerging. However, these new viruses are relatively few in number, which reflects the constraints placed on viral evolution by the requirement for maintenance of virus structure and function and virus adaptation to restricted ecologic sites. Most "new" viral diseases, such as the hemorrhagic fevers, result from environmental disruptions that increase human contact with animals or insect vectors of old viruses. However, truly novel viruses with lethal potential or capacity for global spread have emerged in animals as a consequence of single-point mutations or genetic recombination between viruses. Given the mutability of viruses and the inevitability of environmental change, we must be prepared for the evolution of new virus diseases. (<i>JAMA</i>. 1990;264:68-70)
Albright syndrome and leukemia
Authors: I. Shoulson
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Isolated reports of Albright syndrome have appeared in the literature since his initial description of a disease characterized by fibrous dysplasia of bone, skin pigmentation, and precocious puberty in females.<sup>1</sup>This report describes a patient who demonstrated the features of both Albright syndrome and erythroleukemia, a coexistence not previously reported. <h3>Report of a Case.—</h3> A 65-year-old mother of five had fragile bones since childhood with multiple fractures of the right femur, pigmentation over the buttocks, onset of menarche, and secondary sexual characteristics at the age of 7 years. In March 1971, the patient noted fatigue and was found to have the following peripheral blood values: hemoglobin, 9.4 gm/100 ml; white blood cell (WBC) count, 93,600/cu mm; and a differential count of 97% blast cells. Bone marrow aspiration suggested acute leukemia, type unspecified. Over the ensuing six weeks, the patient was treated with a variety of agents
MEDICINE AND MEDICAL MEN IN THE UNITED STATES.
Authors: A. JACOBI
Journal: JAMA (1900)

It is hardly necessary to say that for those of you for whom the practice of medicine is not only diagnosis and autopsy, but the treatment and cure of the patient in whose behalf a consultation is to be held, when medicinal treatment is in question you can not agree with a homeopath who is a Hahnemannian; and you do not want to meet a homeopath, who, because the name is still fashionable and for a portion of the misinformed public the subject of an almost religious fanaticism, employs that title for meretricious purposes. Still there are cases in which it would be inhuman to refuse a consultation in an urgent case.* Not only were such consultations held from olden times, but even in large cities, exceptions to the rule were always frequent, indeed too frequent in my opinion. Moreover, whoever is acquainted with smaller cities and villages, where a
Vascular malformation of the appendiceal stump. A rare cause of massive hemorrhage
Authors: J. H. Foster
Journal: JAMA (1971)

Seven years after an appendectomy a 32-year-old woman presented with massive gatrointestinal tract bleeding. A preoperative selective superior-mesenteric arteriogram revealed a vascular tumor in the right lower quadrant of the abdomen. The tumor proved to be a vascular malformation of the appendiceal stump which had eroded into the lumen of the cecum and was the source of the massive bleeding. THE frustration accompanying exploratory laparotomy for massive gastrointestinal bleeding and failure to find the source of the bleeding is well known to most general surgeons. Experience with a case of massive bleeding from a vascular malformation of the appendiceal stump, seven years after the appendectomy, was sufficiently preplexing to warrant a brief report. If it had not been for a preoperative arteriogram which showed a vascular tumor mass in the right lower quadrant of the abdomen, it is doubtful that the source of bleeding would have been recognized. <h3>Report of</h3>
Bendamustine, Bortezomib and Dexamethasone (BBD) As First-Line Treatment Of Patients (Pts) With Multiple Myeloma Who Are Not Candidates For High Dose Chemotherapy
Authors: Jesus Berdeja, Michael Savona, Luis Chu, James Essell, Patrick Murphy, Todd Bauer, Eric Raefsky, Ralph V. Boccia, Ian Flinn
Journal: Blood (2013)
Future prospects for the treatment of hemophilia: A global perspective
Authors: David Lillicrap
Journal: HemaSphere (2018)

Department of Pathology and Molecular Medicine, Queen's University, Kingston, Canada This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Clinical effectiveness of influenza vaccination in Manitoba
Authors: D. S. Fedson
Journal: JAMA (1993)

<h3>Objective.</h3> —To assess the clinical effectiveness of influenza vaccination in preventing influenza-associated hospitalization and death. <h3>Design.</h3> —Case-control study. <h3>Setting and Patients.</h3> —Noninstitutionalized persons aged 45 years or older living in Manitoba, on December 1, 1982, and December 1, 1985. <h3>Methods.</h3> —Linked records of the Manitoba population registry, hospital-discharge abstracts, physician claims for ambulatory-patient visits and influenza vaccination, and vital statistics were used. A matched-set analysis estimated the clinical effectiveness of influenza vaccination in preventing hospital admissions and deaths from influenza-associated conditions during influenza A (H3N2) outbreak periods in 1982 to 1983 (12 weeks) and 1985 to 1986 (10 weeks). The analysis adjusted for hospital discharge and ambulatory care for high-risk conditions within the previous 15 months and 3 months, respectively. <h3>Results.</h3> —Influenza vaccination prevented 32% to 39% of hospital admissions with pneumonia and influenza and 15% to 34% of admissions with all respiratory conditions. Vaccination was 43% to 65% effective in preventing hospital deaths with these conditions (all listed diagnoses) and 27% to 30% effective in preventing deaths from all causes. <h3>Conclusion.</h3> —Influenza vaccination has substantial clinical effectiveness in preventing hospital admission and death from influenza-associated conditions in noninstitutionalized individuals. (<i>JAMA</i>. 1993;270:1956-1961)
Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells
Authors: Dan A. Dixon, Neal D. Tolley, Peter H. King, L. Burt Nabors, Thomas M. McIntyre, Guy A. Zimmerman, Stephen M. Prescott
Journal: Journal of Clinical Investigation (2001)

Cyclooxygenase-2 (COX-2) expression is normally tightly regulated. However, constitutive overexpression plays a key role in colon carcinogenesis. To understand the molecular nature of enhanced COX-2 expression detected in colon cancer, we examined the ability of the AU-rich element–containing (ARE-containing) 3′ untranslated region (3′UTR) of COX-2 mRNA to regulate rapid mRNA decay in human colon cancer cells. In tumor cells displaying enhanced growth and tumorigenicity that is correlated with elevated COX-2, vascular endothelial growth factor (VEGF), and IL-8 protein levels, the corresponding mRNAs were transcribed constitutively and turned over slowly. The observed mRNA stabilization is owing to defective recognition of class II-type AREs present within the COX-2, VEGF, and IL-8 3′UTRs; c-myc mRNA, containing a class I ARE decayed rapidly in the same cells. Correlating with cellular defects in mRNA stability, the RNA-binding of trans-acting cellular factors was altered. In particular, we found that the RNA-stability factor HuR binds to the COX-2 ARE, and overexpression of HuR, as detected in tumors, results in elevated expression of COX-2, VEGF, and IL-8. These findings demonstrate the functional significance rapid mRNA decay plays in controlling gene expression and show that dysregulation of these trans-acting factors can lead to overexpression of COX-2 and other angiogenic proteins, as detected in neoplasia.