tbuckley/cabot-search huggingface dataset:
多汗症的二级护理管理
Authors: R. Wade, A. Llewellyn, J. Jones-Diette, K. Wright, S. Rice, A.M. Layton, N.J. Levell, D. Craig, N. Woolacot
Journal: British Journal of Dermatology (2018)

多汗症是指休息时无论温度如何都会不受控制地过度出汗。该疾病会对人们的生活质量造成重大影响。至少1%的英国人被认为受原发性多汗症的困扰。在专业护理中,治疗的有效性存在相当大的差异。本系统性综述来自英国,评估了针对多汗症患者的专业护理中所用治疗的有效性。研究人员进行了全面搜索,以查找多汗症治疗的相关研究。研究质量已接受评估。患者顾问帮助解释了结果。本综述涵盖50项研究,大多数规模小且质量差。评估的治疗包括离子导入法、肉毒杆菌毒素注射、抗胆碱能药物、刮治术以及损害汗腺的其他技术。本综述收集了一些对通过肉毒杆菌毒素注射来治疗腋窝多汗症进行评估的研究,以估计平均效果。我们的综述发现,有中等质量的证据表明,与安慰剂相比(无治疗),肉毒杆菌毒素注射能在短期和中期(多达16周)减轻腋窝多汗症的症状。有虽不充分但一致的证据表明,某些手部多汗症患者从离子导入法中受益。其他干预的相关证据质量很低或极低。总体而言,证明原发性多汗症治疗有效性的证据有限,不能得出可靠结论。但是,有中等质量的证据支持在临床实践中使用肉毒杆菌毒素注射。一项组织妥善且充分的随机对照试验也许能提供保证,该试验对使用肉毒杆菌毒素注射与离子导入法(离子导入法是许多皮肤病科针对影响手掌的手掌多汗症的现行标准治疗)治疗手掌多汗症进行了对比。
Phase 1 trial of JS001, a monoclonal antibody targeting programed death-1 (PD-1) in patients with advanced or recurrent malignancies.
Authors: Jianliang Yang, Sheng Yang, Haifeng Song, Xiaohong Han, Ying Han, Shiyu Jiang, Jiarui Yao, Zhishang Zhang, Shuxiang Zhang, Peng Liu, Yan Qin, Shengyu Zhou, Xiaohui He, Yan Wang, Chengxu Cui, Hui Feng, Sheng Yao, Yan Sun, Yuankai Shi
Journal: Journal of Clinical Oncology (2018)

e15108 Background: JS001, a humanized IgG4 anti-PD-1 antibody developed by Shanghai Junshi Biosciences Co., Ltd., China, showed potent anti-cancer activity in preclinical models. In vivo study suggests it promotes the proliferation of CD62L-CD45RA- effector memory cell effectively. We conducted a phase 1 trial in patients(pts) with advanced or recurrent malignancies. Methods: This trial used a 3+3 design across 3 dose levels: 1, 3, 10 mg/kg/dose. At each level, two schedules were assessed in separate cohorts: single dose and repeated doses every 2 weeks (up to 6 doses). A dose limiting toxicity (DLT) was defined as a Grade≥3 drug-related adverse event (AE) occurring within 28 days of last dosing. An expansion cohort was initiated at the recommended phase 2 dose. Results: Thirty-three pts with advanced or recurrent malignancies were enrolled (single dose escalation: 9 pts; multiple dose escalation: 11, expansion cohort: 13; soft tissue sarcoma: 12; Hodgkin lymphoma, HL: 9; non-small cell lung cancer, NSCLC: 7; diffuse large B-cell lymphoma, DLBCL: 2; adenoid cystic carcinoma, bladder cancer, and nasopharyngeal carcinoma, NPC: each 1). Subclinical abnormal thyroid function in 21 pts, rashes in 11, hepatitis in 2, pneumonia and hypopigmentation in 1 each were considered immune-related AEs. Other treatment-related AEs include influenza-like symptoms, fever, fatigue, mucositis, and decreased lymphocyte count. Most AEs were grade 1-2. No DLT was observed and MTD was not reached. No treatment related deaths occurred. The PK profile supports a biweekly schedule. Best responses were 6 CR/CRu (STS: 1; HL:5), 10 PR (STS: 2; HL:4; DLBCL:1; NSCLC:2; NPC: 1), and 12 SD, yielding a response rate of 48.5% and a disease control rate of 70.0%. The median time to response was 10.6 (range, 5.3 - 35.7) weeks, and the median progression-free survival was 8.8 (1.3 - 14.0+) months. The recommend dose for phase 2 trial was determined as 3mg/kg every 2 weeks. Biomarker analysis is in progress. Conclusions: JS001 showed good tolerance, high response rate and prolonged disease control in advanced or recurrent malignancies, warranting its further development in various tumors. Clinical trial information: NCT02836834. Clinical trial information: NCT02836834.
Spring's here; can end of present influenza season in United States be far behind?
Authors: A. Ritt
Journal: JAMA (1988)

IF ONLY A FEW influenza cases are reported in the next few days, the nation's 1987-1988 flu season may go into the records as notable but not notorious. As a rule of thumb, say officials at the Centers for Disease Control (CDC), Atlanta, if there haven't been unusual numbers of influenza cases reported from all over the nation by this time, it is cause for some optimism. But every season is unique, and the possibility of major outbreaks still exists. "There have been years where things have been puttering along, and then late in the season it picks up," says the CDC's Nancy Arden, MN, who is a nurse. Even during a slow season, increased awareness and improved diagnosis have led to more states reporting isolates of influenza than in the past, says Alan Kendal, PhD, of the CDC's Influenza Branch. Many hospital laboratories are now able to identify influenza
Albendazole—Objective Evidence of Response in Human Hydatid Disease
Authors: David L. Morris
Journal: JAMA (1985)

Thirty-two patients with cysts caused by<i>Echinococcus granulosus</i>were treated with albendazole in a dosage of 10 mg/kg/day. Reversible abnormalities in liver-cell function tests were seen in five patients. Some radiological evidence of remission (on serial computed tomographic or ultrasound scanning) was seen in 15 of 22 patients undergoing a therapeutic course of albendazole (as opposed to those treated before or after surgery). In five patients, the cysts virtually disappeared. Apart from reduction in size, the appearance of a halo around the cysts and the apparent disappearance of daughter cysts has been seen. Serological findings have not correlated well with radiological or clinical improvement. Serum and cyst concentrations of albendazole sulfoxide (the principal metabolite) have been measured. (<i>JAMA</i>1985;253:2053-2057)
Abstract 348: Effects of Normalizing Hyperlipidemia on Oxidative Stress and Disease Progression in a Mouse Model of Aortic Valve Stenosis
Authors: Jordan D Miller, Christopher J Berry, Kristine M Serrano, Robert M Weiss, Nikhil K Iyengar, Kathy A Zimmerman, Stephen J Young, Donald D Heistad
Journal: Circulation (2007)

Treatment of hyperlipidemia produces functional and structural improvement in atherosclerotic vessels. Effects of treatment of hyperlipidemia on structure and function of the aortic valve, however, are controversial, and may be confounded by pleiotropic effects of drugs. We hypothesized treatment of hyperlipidemia using a “genetic switch” in Reversa mice ( Ldlr −/ − / Apob 100/100 / Mttp fl/fl /Mx1 Cre + / + ) would reduce oxidative stress and slow the progression of aortic valve disease. Following 6 months of hyperlipidemia (cholate-free Western diet = WD = 0.25% chol., 21% fat; total cholesterol levels &gt;700 mg/dl), superoxide levels were significantly elevated in the aortic valve (dihydroethidium fluorescence: control = 5 ± 2 U/pixel, WD = 13 ± 3 U/pixel; p &lt; 0.05) with very small reductions in maximum leaflet separation distance obtained from echocardiograms (control = 0.94 ± 0.07 mm, WD =0.89 ± 0.02 mm; p&lt;0.05). In mice maintained on WD for an additional 6 months, leaflet separation decreased to 0.66 ± 0.06 mm (p &lt; 0.05). Rapid normalization of cholesterol levels at 6 months (NC; total cholesterol &lt;200 mg/dl) using a “genetic switch” normalized superoxide levels in the valve (NC = 4 ± 2 U/pixel, p = n.s. versus control animals) and prevented further reductions in leaflet separation distance (NC = 0.89 ± 0.05 mm; p = n.s.). Computerized planimetry of aortic valve area from high resolution cross-sectional magnetic resonance images through the aortic root (4.7 Tesla magnet, 0.04 mm 2 in-plane pixel resolution) confirmed that normalization of cholesterol levels significantly slowed the rate of progression of valve stenosis (Δ valve area from 6–12 months: HC=−6.4 ± 4 %/month, NC = 0.6 ± 4%/month, p&lt;0.05). Collectively, these data suggest that normalization of lipid levels in hypercholesterolemic mice with mild aortic valve disease normalizes oxidative stress and slows the progression of aortic valve stenosis.
The Physician and the Childless Couple
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract LB-512: A novel rotational Raman imaging device for early cancer detection
Authors: Ellis Garai, Cristina Zavaleta, Steve Sensarn, Michael Mandella, Sanjiv S. Gambhir, Christopher H. Contag
Journal: Cancer Research (2012)

Abstract A novel Raman imaging device that is capable of rotationally scanning hollow structures has been developed to be used in conjunction with tumor targeting Surface enhanced Raman scattering (SERS) nanoparticles. SERS nanoparticles can act as excellent contrast agents in that they offer ultra high sensitivity, and multiplexing capabilities due to the unique spectral signatures associated with them. One key advantage of multiplexing includes the ability to utilize several targeted SERS probes to target and localize a multitude of unique biomarkers associated with a specific disease, and effectively increasing cancer specificity. The device can potentially be used to distinguish a variety of tissues of interest in the colon such as: flat lesions, varying types of adenomas and carcinomas. There are also applications beyond the colon, such as the esophagus, stomach, oral cavity and bladder. In addition, multiplexing can allow for real-time functional imaging. A 45-degree scanning mirror, actuated with micro-motor, is used to perform circumferential scans of the lumen of the colon at a rate of 1 revolution per second and a spatial resolution or approximately 1.5 mm. The device is able to be used with currently available endoscopes by inserting it into the working channel of an endoscope. The use of many (36) multi-mode fibers is used to increase the flexibility of the fiber bundle so that it can be inserted and used in a fully articulating endoscope while still being able to collect a sufficient amount scattered Raman light. When in the circumferential scanning mode, American National Standards Institute (ANSI) regulations will allow us to increase the laser illumination power to about 580 mW at a scan rate of 60rpm, resulting in a detection limit of approximately 1 pM of SERS nanoparticles. One of the key features of our Raman device is that it has been designed for efficient use over a wide range of working distances. This is necessary to accommodate for imperfect centering of the device within the colon, as well as variable working distances due to folds and bends within the colon. These techniques could allow endoscopists to distinguish between normal and cancerous tissues instantly, as well as to identify flat lesions that are easily missed during conventional screening endoscopy. After a suspicious region has been identified, the rotating mirror can be held at a certain angle, and used to help guide biopsies or resection of tissues in real-time. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-512. doi:1538-7445.AM2012-LB-512
VACCINATION IN JAPAN
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HOSPITAL SPREAD OF SMALLPOX.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Announcement</i>: Community Preventive Services Task Force Recommendation for Team-Based Care for Patients with Type 2 Diabetes
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

The Community Preventive Services Task Force recently posted new information on its website: "Diabetes Management: Team-Based Care for Patients with Type 2 Diabetes." The information is available at https://www.thecommunityguide.org/findings/diabetes-management-team-based-care-patients-type-2-diabetes.
Determination of Plasma Renin Concentration by Angiotensin I Immunoassay
Authors: JAN R. STOCKIGT, R. DENNIS COLLINS, EDWARD G. BIGLIERI
Journal: Circulation Research (1971)

Radioimmunoassay of angiotensin I was applied to the estimation of renin concentration after incubation of human plasma with an excess of renin substrate from plasma of anephric sheep. With this method markedly subnormal plasma renin levels were accurately measured. The technique was used in the study of 18 patients with proven aldosterone-producing adenoma (APA), 5 with hyperaldosteronism associated with bilateral adrenal hyperplasia, and 23 with essential hypertension. Plasma renin concentration (PRC) was extremely low in APA, and a significantly higher mean basal level of PRC was seen in hyperplastic aldosteronism ( P &lt;0.01). Postural responses were seen in both groups, and PRC was least variable during recumbency. Comparison of basal recumbent PRC with urinary aldosterone after three days of desoxycorticosterone acetate (DOCA) accentuated the distinction between APA and hyperplasia. It is suggested that the prediction of a distinct APA can best be made in patients with hyperaldosteronism when the exact extent of renin suppression is taken into account and when DOCA is used to assess suppressibility of aldosterone. While such evaluation may defer surgery in some patients with correctable hypertension, it may reduce the number with persistent hypertension after bilateral adrenalectomy.
Franz Ingelfinger, MD: a redoubtable character
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DENGUE AND YELLOW FEVER.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Injuries From Ladder Falls Draw Greater Scrutiny
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Software
Authors: William A. Brock
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delivering Twins
Authors: Michael F. Greene
Journal: New England Journal of Medicine (2013)

The rate of twin births in the United States has risen 76% from 1980 through 2009–2011. The rate of rise was particularly steep from the early 1990s through the early 2000s and seems to have reached a plateau of approximately 33.2 twin births per 1000 deliveries in the period from 2009 through 2011.1 The incidence of naturally occurring twin pregnancy rises with increasing maternal age, and the age of women having babies in the United States has risen steadily from 20% of all births among women 30 years of age or older in 1980 to more than 35% for the . . .
The generation gap
Authors: L. B. Berman
Journal: JAMA (1981)

Difficulty arises when young people in nursing, who are in the middle of a self-image revolution, meet older physicians who are unaware, indifferent, or hostile, in varying degrees. One need only scan recruiting ads in nursing journals to see that graduating nurses are being appealed to as glamorous, sophisticated, and intelligent members of the health care team. Beyond the "hype," however, is a serious movement in nursing to provide education credentials up to and beyond a master's degree, and to establish nurses as separate but equal health care professionals. Young nursing school graduates, having been provided with this view of themselves, enter the hospital world and collide with physicians who see nurses as none of the above. Instead, depending to some extent on their age, physicians may perceive nurses as handmaidens, drudges, or coffee pourers, on whom they may vent annoyance with the laboratory and x-ray; or they may perceive