tbuckley/cabot-search huggingface dataset:
Factitious Asthma
Authors: Edward T. Downing
Journal: JAMA (1982)

Three patients with recurrent emergency room visits and hospitalizations for bronchial asthma are described. Although each patient had respiratory distress associated with wheezing and an apparent response to conventional therapy, other features were inconsistent with the pathophysiology of asthma. These included absence of a significantly elevated alveolar-arterial oxygen tension difference, lack of roentgenographic hyperinflation, and normal small airway function soon after clinical response. Furthermore, bronchial hyperreactivity, a constant feature of asthma, was absent in all patients. Each patient demonstrated wheezing that was self-induced and heard loudest over the neck. Two patients had previous psychiatric illness, one of whom had been hospitalized for factitious fever. We believe that these patients had a form of factitious illness not previously described. Recognition of this syndrome may avoid unnecessary medical care and allow initiation of appropriate psychiatric follow-up. (<i>JAMA</i>1982;248:2878-2881)
Legal limits of AIDS confidentiality
Authors: B. M. Dickens
Journal: JAMA (1988)

THE IMPACT that the acquired immunodeficiency syndrome (AIDS) is having on social relationships finds expression in legal relationships. The medical or health care setting is only one of many in which legal rights, duties, and powers are affected by individuals' liability to transmit or to suffer from human immunodeficiency virus (HIV) infection.<sup>1</sup>Medical diagnosis, care, and counseling of patients with AIDS certainly raise crucial concerns of health care professionals, allied health workers, and patients. Their concerns are, however, representative rather than exhaustive of those felt throughout society. Fears of HIV infection contracted in the workplace are unreasonable, but nevertheless commonplace, in all but a few occupations. Where fellow employees risk wounds that bleed, for instance, colleagues may demand protection. In schools, teaching and auxiliary staff may fear exposure to children's body fluids, more frequently passed, no doubt, by younger children, and the same is true in day-care centers. Proximately
Collaterals
Authors: Alona Zer, Yael Rapson, Salomon M. Stemmer
Journal: Journal of Thoracic Oncology (2013)

A 66-year-old man was referred for evaluation because of new-onset facial swelling and right upper lobe pneumonia. Physical examination revealed mild facial and upper extremity edema and prominent collateral veins on his chest, abdomen, back, and right flank. A computed tomography scan of the chest showed a right upper lobe mass, invading the mediastinum and obstructing the superior vena cava (SVC). Prominent collateral blood vessels were seen in the chest wall, flank, and abdomen. The patient underwent bronchoscopy and biopsy of the right upper lobe mass, which demonstrated squamous cell carcinoma, stage IIIB (T4N3M0). After the first week of chemoradiation, a relief of his symptoms was observed. Lung cancer is the most common cause of SVC syndrome. When the SVC is obstructed, an extensive venous collateral circulation may develop, including the azygos venous system, internal mammary veins, lateral thoracic veins, paraspinous veins, and esophageal venous network. The subcutaneous veins are important pathways, as demonstrated in this case (FIGURE 1, FIGURE 2, FIGURE 3, FIGURE 4).FIGURE 2CT—axial view of the same CT scan. CT, computed tomography.View Large Image Figure ViewerDownload (PPT)FIGURE 3CT—axial view of the same CT scan. CT, computed tomography.View Large Image Figure ViewerDownload (PPT)FIGURE 4Physical examination—a prominent venous pattern on chest and abdomen.View Large Image Figure ViewerDownload (PPT)
Splenic repair in agnogenic myeloid metaplasia
Authors: J. F. Jaramillo
Journal: JAMA (1980)

LACERATION of the spleen in a patient with agnogenic myeloid metaplasia (AMM) was successfully treated with splenorrhaphy. Splenectomy is hazardous in AMM, and repair should be a useful alternative. <h3>Report of a Case</h3> A 57-year-old woman was admitted on Oct 21, 1977, to St Mary's Hospital, Saginaw, Mich, after sustaining trauma to the chest and abdomen in a car accident. The patient's condition had previously been diagnosed as AMM. On admission, blood pressure was 100/60 mm Hg; pulse rate, 84 beats per minute; temperature, 36.7 °C. The patient was alert and complained of left upper quadrant pain radiating to the left shoulder. Deep palpation elicited tenderness in the left upper quadrant of the abdomen, with no demonstrable splenomegaly. Laboratory data included the following values: WBCs, 19,400/cu mm, with 43% polymorphonuclear leukocytes, 31% band forms, 15% metamyelocytes, 4% lymphocytes, and 2% monocytes; hemoglobin, 10.5 g/dL; platelets, 309,000/cu mm; prothrombin time, 12.8
Propranolol in the management of hypertension in a long-term dialysis program
Authors: E. C. Smith
Journal: JAMA (1974)

IN patients with chronic renal failure requiring maintenance dialysis, hypertension is frequently difficult to control without bilateral nephrectomy. Because of surgical risks in uremic patients, and also because of the complicating postnephrectomy anemias and problems in fluid and electrolyte balance, it is desirable to avoid nephrectomy. This is true particularly in view of the observed occasional improvement in renal function after several months of dialysis. Recently there have been reports on the value of propranolol hydrochloride in controlling severe hypertension in nonuremic patients.<sup>1</sup>We are reporting a trial of this drug in patients with uremia. <h3>Patients and Methods</h3> Six of the 20 patients on the longterm dialysis program have had persistent hypertension, despite therapy with furosemide, methyldopa, hydralazine hydrochloride, and guanethidine sulfate, and rigorous control of sodium intake and weight gain between dialyses. Many were experiencing postural hypotensive effects, drowsiness, and impotence, and were therefore at the limit of
SMALLPOX AND TRAMPS.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mammography, Needle Biopsy, and Tumor Spread
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1957)

RECOMMENDATIONS IN REPORTS TO BE CONSIDERED AT THE ANNUAL MEETINGThe Executive Committee and Council will be asked to take action on at least twenty-two committee reports at their respective meetings on April 24 and May 20.The Subcommittee on Blue Cross–Blue Shield Problems will recommend to the Executive Committee that the resolution from Middlesex South, urging the adoption by Blue Shield of a differential fee schedule for physicians who restrict their practice to internal medicine, be not approved. The Committee expresses its opinion that no distinction should be made feewise in respect to the same or similar services rendered . . .
LITERATURE
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nosocomial meningitis of the newborn caused by a flavobacterium
Authors: S. A. Plotkin
Journal: JAMA (1966)

GRAM-NEGATIVE as well as gram-positive bacteria may be agents of infection in a nursery for the newborn. A number of species of gram-negative bacteria are capable of multiplying at ordinary room temperature in aqueous environments devoid of organic carbon and nitrogen sources. These organisms have been termed "water bugs"<sup>1</sup>and have been the cause of many documented epidemics of neonatal meningitis.<sup>2-6</sup> We report here two cases of meningitis in newborns caused by flavobacteria that were apparently transmitted via saline solution used to wash the infants' eyes at birth. Hydrocephalus developed in both patients, and one died, which illustrated the seriousness of the infection. <h3>Report of Cases</h3><h3>Case 1.—</h3> A boy was born at term on April 16, 1965, in a 50-bed rural hospital in the Philadelphia area. The pregnancy had been uneventful except for an episode of urinary tract infection during the sixth month, which was treated with
Letter: Amniocentesis in tay-Sachs disease
Authors: Harold Schwartz
Journal: JAMA (1975)

<h3>To the Editor.—</h3> I wish to reply to Dr. Fred Rosner's letter in the May 13 issue ofThe Journal(228:829, 1974) regarding amniocentesis for Tay-Sachs disease. Dr. Rosner does not speak as a doctor for the obstetrician-gynecologist, pediatrician, psychiatrist, or for the geneticist. He speaks only for a small segment of Orthodox Jews, and I can refer him to<i>Birth Control in Jewish Law</i>by David M. Feldman: Mental health risk has been definitely equated to physical-health risk. This woman who is in danger of losing her mental health unless the pregnancy is interrupted, therefore would accordingly qualify.<sup>1</sup> The majority of the Jewish houses of worship in Baltimore took part in the massive screening for Tay-Sachs disease and, not too long ago, this was repeated in a Union, NJ, synagogue. We can only pray for the future that possible enzyme replacement may solve this and other sphingolipidrelated diseases.
Wording Errors in: The Older Smoker
Authors: Bryan Denham
Journal: JAMA (2011)

ments" containing steroids, and under the direction of the FDA, Bodybuilding.comsubsequently recalled the supplements from the marketplace. 3As part of their initial investigation, FDA officials had purchased 31 supplements from Bodybuilding.com, and 26 (84%) had contained at least 1 controlled substance. 4Although the entire supplement industry cannot be held accountable for the spiked products of an online "nutrition" site, a question does arise as to whether such problems can be prevented in the future.Unless DSHEA is reformed, I suspect companies that seek only to maximize profit will continue to take their chances in the marketplace, betting that the FDA and other federal agencies will not target their products.
Travelers' Diarrhea
Authors: Sherwood L. Gorbach
Journal: New England Journal of Medicine (1982)

Travel expands the mind and loosens the bowels. The naive voyager is initiated to many unexpected pleasures and experiences, but a not infrequent accompaniment to such adventures is a bout of debilitating diarrhea. Annually, more than 250 million people travel from one country to another, and tourism has become economically important, especially in developing countries. United States citizens traveling to Mexico alone number three million per year. With an attack rate of 25 to 50 per cent, diarrheal illness may affect more than a million of these visitors yearly; 30 per cent will be ill enough to be confined to . . .
Conversion of xanthine dehydrogenase into xanthine oxidase in rat liver and plasma at the onset of reperfusion after ischemia
Authors: A Kooij
Journal: Hepatology (1994)

The aim of this study was to test whether conversion of xanthine dehydrogenase into xanthine oxidase as induced by fasting, ischemia of the liver or both is an in vivo process or only occurs in vitro in homogenates. For this purpose, the conversion rate of xanthine dehydrogenase into xanthine oxidase was studied in liver homogenates obtained from rats after normal feeding or 24 hr of fasting followed or not by 2 hr of ischemia of the liver. In fed rats, the conversion rate of xanthine dehydrogenase into xanthine oxidase was studied as well in liver homogenates after different periods of reperfusion after 2 hr of ischemia. Homogenization was carried out under strictly controlled conditions, after which the supernatants were incubated at 37° C in buffer for 0 to 5 hr. Enzyme activities were assayed spectrophotometrically by measuring urate production at 295 nm. Conversion started only after 2 to 3 hr of incubation of supernatants of control fed livers, whereas conversion started immediately after 24 hr of fasting. The percentage oxidase activity of total xanthine oxidoreductase activity in ischemic livers from fed animals was slightly higher (26.7% ± 1.7%; p<0.05) than in control livers (19.3% ± 1.4%), whereas the percent oxidase activity in ischemic livers from fasted animals (16.7% ± 1.0%) was not different from that in control animals (16.8% ± 1.1%). Ischemia for 2 hr caused in vitro a substantial increase in the conversion rate in supernatants of livers of fed and fasted rats as compared with their controls. Furthermore, the appearance of xanthine dehydrogenase and xanthine oxidase in the blood during reperfusion up to 60 min after 2 hr ischemia of the liver was studied. The enzyme started to appear in the blood after 5 min of reperfusion, predominantly as xanthine dehydrogenase. Very rapid conversion of xanthine dehydrogenase into xanthine oxidase was observed in the plasma. We conclude that fasting and 2-hr in vivo ischemia of rat liver can affect the conversion rate of xanthine dehydrogenase into xanthine oxidase during homogenization but not in vivo. Therefore initial tissue injury due to in vivo ischemia and reperfusion in liver is not caused by conversion of xanthine dehydrogenase into xanthine oxidase. It cannot be ruled out that, after leakage of the enzyme to the circulation, additional damage is induced. (HEPATOLOGY 1994;19:1488–1495.)
Neomycin Sensitivity
Authors: Gregory J. Firman
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I read with interest the article by Davis et al on "The Value of Neomycin in a Neomycin-Steroid Cream" (<b>203</b>: 298, 1968). Their conclusion (ie, that neomycin added to a topical steroid does not increase its efficacy in pyogenic bacterial infections and further may encourage the emergence of neomycin-resistant strains of staphylococci) is certainly worthy of wide attention. The authors make a second point, which is worthy of emphasis: Allergic sensitivity to neomycin has been observed and is an additional hazard in its topical use. A review of "Hypersensitivity Skin Reactions Due to Neomycin"<sup>1</sup>stressed first, that contact allergy to neomycin is quite common; second, the steroid in the combination preparation does not block such allergic reactions; third, reactions to neomycin may convert a nonspecific dermatitis to an allergic contact dermatitis with little change in signs or symptoms; and, last, once sensitization to neomycin has occurred,
Cataract: Its Etiology and Treatment
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeted Modifications in Adeno-Associated Virus Serotype (AAV)- 8 Capsid Improves Its Hepatic Gene Transfer Efficiency in Vivo
Authors: Dwaipayan Sen, Nishanth Gabriel, Sathish Kumar Yesupatham, Rekha Samuel, Rupali A Gadkari, G Sudha, N Srinivasan, Alok Srivastava, Giridhara Rao Jayandharan
Journal: Blood (2012)
Nonsurgical ovum transfer as a treatment in infertile women. Preliminary experience
Authors: M. Bustillo
Journal: JAMA (1984)

This report summarizes our experience with nonsurgical ovum transfer at Harbor-UCLA Medical Center. In 29 attempts, 12 ova have been recovered and transferred. Two ongoing intrauterine recipient pregnancies have resulted from this preliminary research. There were two complications: one ectopic pregnancy in a recipient woman and one retained pregnancy in a donor woman who aborted spontaneously. (<i>JAMA</i>1984;251:1171-1173)
LEADING ARTICLE
Authors: D. S. Tunstall Pedoe
Journal: British Journal of Sports Medicine (1978)

of Medicine in June 1978.The aim of the conference was to discuss and publicise the medical evidence for the benefits and risks of exercise.It was generously supported by both the Sports Council and the Health Education Council.As organiser of the conference I was very conscious of the fact that many of the non-medical members of the audience were intrigued by the fact that the medical men had such difficulty proving the 'obvious benefits' of exercise.
Issues Regarding Antiretroviral Treatment for Patients With HIV-1 Infection
Authors: Margaret Chesney
Journal: JAMA (1997)

<h3>To the Editor.</h3> —In their Consensus Statement, Dr Carpenter and colleagues<sup>1</sup>stress that adherence to the drug regimen is critical for reducing plasma human immunodeficiency virus (HIV) RNA levels, protecting against drug resistance and cross-resistance, and enhancing patient health. Decisions to initiate combination therapy must take into account patients' willingness to adhere to complex and costly regimens that may include 20 or more pills per day. Even brief periods of nonadherence to treatment regimens can result in increased viral load and drug resistance.<sup>1,2</sup> Despite this, there is a dearth of information about adherence to therapy for HIV disease. Little is known about shortterm or long-term patterns of adherence to regimens like those recommended, how adherence behavior may change in response to disease progression, and factors that predict adherence and could be targeted for interventions.<sup>3</sup>There is an immediate need to understand adherence behavior to realize the benefits
Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment
Authors: F. R. Kandeel
Journal: Endocrine Reviews (2001)

This review is designed to help the reproductive endocrinologist integrate his or her professional activity with those of other disciplines including urology, radiology, neurology, and psychology in order to successfully manage all of the inseparable aspects of male sexual and reproductive functioning. Significant advances in the field of male sexual physiology and pathophysiology and new methods of investigation and treatment of male sexual disorders are outlined. The review synthesizes available data on the following: norms of sexual organs, aging and sexuality, role of central and peripheral neurochemicals in each stage of the sexual cycle, role of corporeal smooth muscles in the hemodynamic control of erection and detumescence, influence of psychological factors, drugs, and disease on all aspects of sexual functioning, and use of nocturnal penile tumescence monitoring, imaging investigations, and neurophysiologic studies in the diagnostic workup of males with sexual dysfunction. Clinical algorithms are presented where appropriate. Extensive discussions on newly developed strategies in psychological and behavioral counseling, drug therapy, tissue engineering, nonsurgical devices, and surgical treatments for all forms of sexual disorders are also provided. Lastly, the effect of sexual dysfunction and its treatment on quality of life in affected men is addressed, along with recommendations for future research endeavors.
Sumoylated HSP90 is a dominantly inherited plasma cell dyscrasias risk factor
Authors: Klaus-Dieter Preuss, Michael Pfreundschuh, Martin Weigert, Natalie Fadle, Evi Regitz, Boris Kubuschok
Journal: Journal of Clinical Investigation (2015)

At the request of the corresponding author, the JCI is retracting the paper "FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer" based on findings of data falsification and fabrication regarding Figures 1D and8A, likely data falsification regarding Figure 4A, likely falsification or fabrication regarding Figure 4B, and erroneous sample attribution in Table 1.