tbuckley/cabot-search huggingface dataset:
Trefoil peptides
Authors: W M WONG, R POULSOM, N A WRIGHT
Journal: Gut (1999)

The trefoil factor family (TFF) is a relatively new family of peptides which bear the three-loop trefoil domain.They are mainly synthesised and secreted by mucin secreting epithelial cells lining the gastrointestinal tract and have a close association with mucins.They are highly conserved during evolution and are heat, acid and enzyme resistant.Their abundant expression in distinct patterns in the normal physiological state and ectopic expression in various ulcerative conditions suggests an important role in mucosal defence and repair.Expression of TFF peptides in neoplasia has stimulated interest in deducing the biological role of these peptides in tumour progression.The underlying molecular mechanism of TFF peptide action is still unknown, but their physical properties, and the biological activities of these peptides as motogens may prove to be useful as therapeutic agents in ulcerative conditions, including inflammatory bowel disease where present treatment is far from ideal.
Nylon Dermatitis
Authors: George E. Morris
Journal: New England Journal of Medicine (1960)

NYLON is a polyamide resin noted for its great flexibility and tensile strength. The term "nylon" does not refer to a particular product, but rather to a family of chemically related products, which may be fabricated and used in many different physical forms,1 such uses being universally recognized. Shortly after its introduction commercially in 1940, nylon was suspected of being a skin sensitizer, but studies at that time showed the dermatoses to be due either to the specific finishes of the nylon2 or to the dyes employed in its preparation,3 and nylon itself was exonerated. Later, as a result of . . .
IMPROVED TREATMENT OF EMPYEMA.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Leland S. McKittrick
Journal: New England Journal of Medicine (1946)

SUBCOMMITTEE ON MEDICAL ECONOMICS, POSTWAR PLANNING COMMITTEEInformation Concerning Recent DeliberationsThe Subcommittee on Medical Economics met on September 13, 1945, to study Senate Bill 1050, the so-called "Wagner–Murray–Dingell Amendment to the Social Security Act."It was soon obvious that before any critical study of this or any proposed legislation could be made, certain guiding principles on which all could agree should be formulated.It was also pointed out that Senate Bill 1318, the so-called Pepper "Maternal and Child Welfare Act of 1945," might soon come up in committee and that a study of this bill should take precedence over . . .
A Graphical Analysis of the Interrelationships among Waterborne Asbestos, Digestive System Cancer and Population Density
Authors: Michael E. Tarter, Robert C. Cooper, William R. Freeman
Journal: Environmental Health Perspectives (1983)

Five statistical procedures were used to partial the correlation between waterborne asbestos and digestive site cancer for the putative effects of population density. These include: analysis based on a data subset with roughly homogeneous population density; standard residual analysis (partial correlation); conditional probability integral transformation; analysis based upon ranked data, and use of logarithmic transformation. Nonparametric regression graphical techniques are applied to examine the nature or shape of the asbestos-cancer dose-response curve. Evidence is presented that suggests that there is considerable difference between analyses involving nonhigh-density tracts and non-San Francisco tracts. Evidence is also presented that the modal-type nonparametric regression curve forks or bifurcates when adjustment is made for population density.
Hearing voices
Authors: M Romme, S Escher
Journal: BMJ (1994)

of couple therapy, whether analytically or behaviourally based, focused on the couple's inter- action and mutual projections are totally different from the psychodynamics of one to one examination of an individual's personal anxieties.Nigel Mather and colleagues' paper attempted only to assess how far achievement of this brief technique is possible by seminar training with leaders who are not psychoanalysts.3It is good to know that the multidisciplinary British Association of Sexual and Marital Therapists has now begun to offer training and is using the seminar method.I look forward to its assessment of results.
Principles and Practice of Chemotherapy: With Special Reference to the Specific and General Treatment of Syphilis.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Morphologic and molecular genetic aspects of oligodendroglial neoplasms
Authors: Sandra H. Bigner, B.K. Ahmed Rasheed, Rodney Wiltshire, Roger E. McLendon
Journal: Neuro-Oncology (1999)

Morphologic criteria for diagnosing oligodendrogliomas and for classifying them as well-differentiated (World Health Organization grade II) and anaplastic (World Health Organization grade III) are well recognized.Nevertheless, applying these guidelines to speci c cases often reveals discrepancies among different observers.In addition, whether a given tumor also contains an astrocytic component may be debatable.Loss of heterozygosity studies have demonstrated that oligodendroglial neoplasms have a high incidence of loss of the 1p and 19q chromosomal arms.Although loss of heterozygosity for portions of 19q are sometimes seen in astrocytic neoplasms, these tumors seldom show complete loss of 19q accompanied by loss of 1p.Loss of 9p or homozygous deletion of the CDKN2 gene or both are associated with anaplastic oligodendrogliomas, whereas loss of 17p or TP53 gene mutations or both are frequent in astrocytomas, but rare in oligodendrogliomas.These observations suggest that molecular genetic parameters could provide an objective, reproducible framework for classifying oligodendroglial neoplasms.
Oklahoma okays an unproved therapy
Authors: H. Page
Journal: JAMA (1982)

Oklahoma became the first state in the nation to enact a law permitting the use of "immunoaugmentative therapy" (IAT or IAT blood fractions) for the treatment of cancer and other diseases when Governor George Nigh signed the bill March 2. The Oklahoma House had passed the bill 97 to 0 on Feb 3, and the Senate had passed it 37 to 0 on Feb 25. The law prohibits any hospital from restricting use of the therapy and bans the state Board of Medical Examiners and the state Board of Osteopathic Examiners from disciplining any physician who prescribes the therapy. It does provide, however, that IAT can be given only to a patient who signs a "written informed request" form from the State Board of Health. This form states that the therapy has not "been approved as a preventative, treatment, or cure for any malignancy, disease, illness, or physical condition by
Effects of spontaneous myocardial oscillation on cardiac function: direct observation of the epicardial fluorescence image in calcium overloaded isolated hamster hearts
Authors: T SHINOZAKI, N ISHIDE, M SATOH, K SHIRATO
Journal: Cardiovascular Research (1996)

Calcium overload induces spontaneous cyclic calcium release from the sarcoplasmic reticulum, leading to spontaneous myocardial oscillation. This study was designed to elucidate (1) the effect of the myocardial oscillation on changes in ventricular performance and (2) how these changes relate to the strength of the diastolic spontaneous myocardial oscillation and the spatial extent--that is, in how extensive an area of the epicardium it occurred.the isovolumic pressure of the left ventricle and epicardial fura 2 fluorescence in isolated hamster hearts were simultaneously observed at various calcium concentrations ([Ca2+]o). Endothelial cells and pericytes of the capillaries, preferentially stained by fura 2, were passively oscillated by surrounding myocytes during diastole at concentrations greater than 1 mmol/l of [Ca2+]o. The strength of the myocardial oscillation was evaluated as the root mean square (RMS) of fluctuation in the distance between endothelial cells or pericytes. The spatial extent of the myocardial oscillation was estimated as the appearance rate, defined as the ratio of the number of microscopic fields showing the capillary oscillation, to the total number of examined fields.Up to 4 mmol/l of [Ca2+]o, developed pressure and maximum rate of pressure rise significantly increased in a manner dependent on [Ca2+]o, but a further increase in [Ca2+]o significantly decreased these parameters. In the presence of ryanodine (2.5 mumol/l), developed pressure and maximum rate of pressure rise monotonously increased in a manner dependent on [Ca2+]o. Although the oscillation was never observed at 1 mmol/l of [Ca2+]o (appearance rate = 0%), it occurred in some of the microscopic fields at 2 and 4 mmol/l (appearance rate = 19.5 and 56.3%, respectively) and occurred in all microscopic fields at concentrations greater than 4 mmol/l (appearance rate = 100%). Ryanodine, which completely eliminated the capillary oscillation, inhibited the increase of both RMS and end-diastolic pressure by an increase in [Ca2+]o.Our data suggest that the myocardial oscillation impairs systolic and diastolic function in intact ventricle, and that these effects are associated with the spatial extent and the strength of the myocardial oscillation.
163P Safety analysis of FOLFOX as adjuvant chemotherapy for stage III colon cancer in phase II study (NORTH/HGCSG1003) - an analysis of surgeons vs oncologists
Authors: A. Ishiguro, S. Yuki, Y. Kawamoto, F. Nakamura, N. Takahashi, T. Shichinohe, T. Kusumi, S. Sogabe, K. Hatanaka, K. Misawa, M. Nenohi, H. Hayashi, H. Fukushima, M. Takahashi, T. Amano, Y.M. Ito, N. Sakamoto, A. Taketomi, S. Hirano, Y. Komatsu
Journal: Annals of Oncology (2015)
Lipoprotein(a) levels and risk of coronary heart disease in men. The lipid Research Clinics Coronary Primary Prevention Trial
Authors: E. J. Schaefer
Journal: JAMA (1994)

<h3>Objective.</h3> —To examine the relationship between elevated levels of lipoprotein(a) [Lp(a)] and coronary heart disease (CHD) risk in a prospective study. <h3>Design.</h3> —Nested case-control study. The cohort consisted of participants in the Lipid Research Clinics Coronary Primary Prevention Trial. <h3>Setting.</h3> —Lipid research clinics. <h3>Participants.</h3> —The Lipid Research Clinics Coronary Primary Prevention Trial participants (n=3806) were men, aged 35 to 59 years, with plasma cholesterol levels of 6.85 mmol/L (265 mg/dL) or greater, low-density lipoprotein cholesterol levels of 4.91 mmol/L (190 mg/dL) or greater, and triglyceride levels less than 3.39 mmol/L. Subjects were randomly assigned to either cholestyramine or placebo treatment. The Lp(a) levels were measured in plasma samples obtained prior to randomization in 233 cases (participants who developed CHD in the course of the study) and 390 matched CHD-free controls. A total of 96.95% of the subjects were white, 2.25% were black, and 0.80% were of other race. <h3>Main Outcome Measure.</h3> —Coronary heart disease (either fatal or nonfatal) events during a follow-up of 7 to 10 years. <h3>Results.</h3> —The Lp(a) levels were significantly higher (21%) in cases than in controls (23.7 mg/dL [0.59 mmol/L and 19.5 mg/dL [0.49 mmol/L], respectively;<i>P</i>&lt;.02). This difference was still statistically significant (<i>P</i>&lt;.01) after controlling for age, body mass index, cigarette smoking, blood pressure, low-density lipoprotein cholesterol level, and high-density lipoprotein cholesterol level. When subjects were divided by treatment, both cholestyramine-treated and placebo-treated CHD subjects had Lp(a) levels 20% to 22% greater than their matched controls. However, possibly because of smaller sample sizes, these differences were no longer statistically significant. <h3>Conclusions.</h3> —Our data are consistent with the concept that an elevated Lp(a) level is an independent risk factor for CHD in hypercholesterolemic white men. (<i>JAMA</i>. 1994;271:999-1003)
Bone marrow drives central nervous system regeneration after radiation injury
Authors: Jorg Dietrich, Ninib Baryawno, Naema Nayyar, Yannis K. Valtis, Betty Yang, Ina Ly, Antoine Besnard, Nicolas Severe, Karin U. Gustafsson, Ovidiu C. Andronesi, Tracy T. Batchelor, Amar Sahay, David T. Scadden
Journal: Journal of Clinical Investigation (2018)

During the assembly of Figure 4A, an incorrect image was inadvertently used for the SVZ section for the whole-body XRT sample.The correct figure panel is below.
Low expression of erythrocyte complement receptor type 1 induces defective immune complex clearance in chronic hepatitis C patients . 1) 1st Dept. of Med., Osaka Univ. Med. School, Suita Japan. 2)Dept of Gastroenterol., Osaka National Hosp., Osaka, Japan. 3)Dept. of Med., Shin-Senri Hosp., Suita, Japan
Journal: Hepatology (1995)
Invokamet and Xigduo XR – Two New Combinations for Type 2 Diabetes
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism
Authors: Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling, Hannah Ahn, Lee R. Hagey, Casey E. Romanoski, Richard G. Lee, Mark J. Graham, Hozumi Motohashi, Masayuki Yamamoto, Peter A. Edwards
Journal: Cell Metabolism (2016)
PROGNOSIS OF FOREIGN BODY IN THE LUNG
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NUMERICAL PREDOMINANCE OF WOMEN OVER MEN IN THE UNITED STATES
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathobiological and Behavioral Effects of Lead Intoxication in the Infant Rhesus Monkey
Authors: J. R. Allen, P. J. McWey, S. J. Suomi
Journal: Environmental Health Perspectives (1974)

When infant rhesus monkeys were exposed to lead via the addition of lead acetate (0.5–9 mg/kg body weight) to their formula or by the consumption of lead particles from lead-based surrogate mothers, they developed symptoms of lead intoxication within 6 weeks. Seizures, muscular tremors, and altered social interaction were the predominant changes. Visual impairment was also apparent in the more severely affected animals. In the animals showing obvious symptoms lead levels varied between 300 to 500 μg/100 ml of blood. Even in those animals having blood lead levels below 100 μg, hyperactivity and insomnia were observed. When the exposure to lead was eliminated, seizures subsided and visual impairment was reduced; however, the abnormal social interaction persisted. These animals also experienced a gradual decline in hematocrit and hemoglobin values during the period of examination. Liver and kidney biopsies obtained from these lead-exposed animals revealed characteristic intranuclear inclusions. When adolescent and adult monkeys were exposed to doses of lead acetate similar to those employed in the infant experiments, lead levels in excess of 200 μg/100 ml of blood were recorded. However, there were no obvious behavioral abnormalities observed. There were, however, numerous lead inclusion bodies in kidney biopsy specimens from these animals. These data suggest that, like man, the infant nonhuman primate is much more susceptible to lead intoxication than is the adult. The clinical and behavioral changes recorded in these infant rhesus monkeys suggest their use as an experimental model to evaluate lead intoxication.
Abstract A18: The role of the microenvironment protein cathelicidin LL-37 in pancreatic ductal adenocarcinoma
Authors: Bruno Sainz, Javier Frias, Michele Cioffi, Sonia Alcala, Christopher Heeschen
Journal: Cancer Research (2013)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR1) of the Conference Proceedings. Citation Format: Bruno Sainz, Jr., Javier Frias, Michele Cioffi, Sonia Alcala, Christopher Heeschen. The role of the microenvironment protein cathelicidin LL-37 in pancreatic ductal adenocarcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A18.
Final Visit
Authors: Elizabeth Toman
Journal: Annals of Internal Medicine (2010)

On Being a Doctor1 June 2010Final VisitElizabeth Toman, MDElizabeth Toman, MDFrom New Mexico Veterans Affairs Health Care System, Albuquerque, NM 87108.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-11-201006010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail They weep when I tell them I am leaving. Mrs. Aguilar and her sister both dab at their eyes with the rough paper towels I offer them. The box of tissues is missing from the examination room, a sign that the day will not go well. Weeping is another. These goodbyes are slowing me down, and I have a full schedule today.“But you have always been my doctor,” says Mrs. Aguilar. “You take such good care of me.” Neither statement is true. Mrs. Aguilar's chronic illness began years before I came to this clinic. Her problem list was already ... Author, Article, and Disclosure InformationAffiliations: From New Mexico Veterans Affairs Health Care System, Albuquerque, NM 87108.Corresponding Author: Elizabeth Toman, MD, 1501 San Pedro Drive Southeast, Albuquerque, NM 87108; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 2010Volume 152, Issue 11Page: 749-750KeywordsBloodChartsCholesterolGlucoseHeart failureInsulinOsteoporosisStrokeThyroidUrine ePublished: 1 June 2010 Issue Published: 1 June 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...