Predictors of Pregnancy Outcomes in Patients With Lupus
Authors: Lionel Carbillon, Amelie Benbara, Jeremy Boujenah, Claire de la Hosseraye, Arsene Mekinian
Journal: Annals of Internal Medicine (2016)

Letters19 January 2016Predictors of Pregnancy Outcomes in Patients With LupusLionel Carbillon, MD, PhD, Amelie Benbara, MD, Jeremy Boujenah, MD, Claire de la Hosseraye, MD, and Arsene Mekinian, MD, PhDLionel Carbillon, MD, PhDFrom Assistance Publique-Hôpitaux de Paris, University of Paris 13, Paris, France.Search for more papers by this author, Amelie Benbara, MDFrom Assistance Publique-Hôpitaux de Paris, University of Paris 13, Paris, France.Search for more papers by this author, Jeremy Boujenah, MDFrom Assistance Publique-Hôpitaux de Paris, University of Paris 13, Paris, France.Search for more papers by this author, Claire de la Hosseraye, MDFrom Assistance Publique-Hôpitaux de Paris, University of Paris 13, Paris, France.Search for more papers by this author, and Arsene Mekinian, MD, PhDFrom Assistance Publique-Hôpitaux de Paris, University of Paris 13, Paris, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-0499 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Buyon and colleagues (1) assessed the predictors of adverse pregnancy outcomes (APOs) in patients with inactive or stable active systemic lupus erythematosus in a prospective, multicenter cohort that included 385 patients. They identified diverse baseline predictors of APOs—among which the presence of lupus anticoagulant (LAC) and antihypertensive use were the strongest—with an APO rate as high as 58.0% and a neonatal mortality rate of 22.0% for the women who were LAC-positive and received antihypertensive therapy. However, 48 women were classified antiphospholipid antibody–positive and 34 were LAC-positive, which probably explains why 83 received prophylactic treatment with heparin, aspirin, ...References1. Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, et al. Predictors of pregnancy outcomes in patients with lupus: a cohort study. Ann Intern Med. 2015;163:153-63. [PMID: 26098843]. doi:10.7326/M14-2235 LinkGoogle Scholar2. Caruso A, De Carolis S, Ferrazzani S, Valesini G, Caforio L, Mancuso S. Pregnancy outcome in relation to uterine artery flow velocity waveforms and clinical characteristics in women with antiphospholipid syndrome. Obstet Gynecol. 1993;82:970-7. [PMID: 8233274] MedlineGoogle Scholar3. Venkat-Raman N, Backos M, Teoh TG, Lo WT, Regan L. Uterine artery Doppler in predicting pregnancy outcome in women with antiphospholipid syndrome. Obstet Gynecol. 2001;98:235-42. [PMID: 11506839] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Assistance Publique-Hôpitaux de Paris, University of Paris 13, Paris, France.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L15-0499. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPredictors of Pregnancy Outcomes in Patients With Lupus Jill P. Buyon , Mimi Y. Kim , Marta M. Guerra , Carl A. Laskin , Michelle Petri , Michael D. Lockshin , Lisa Sammaritano , D. Ware Branch , T. Flint Porter , Allen Sawitzke , Joan T. Merrill , Mary D. Stephenson , Elisabeth Cohn , Lamya Garabet , and Jane E. Salmon Predictors of Pregnancy Outcomes in Patients With Lupus Jill P. Buyon , Mimi Y. Kim , and Jane E. Salmon Metrics Cited byLe syndrome des antiphospholipides obstétrical : quelle est la place d’un traitement complémentaire à la combinaison aspirine et héparine ? 19 January 2016Volume 164, Issue 2Page: 131KeywordsAntibodiesApolipoproteinsAspirinHeparinLupus erythematosusManagement of high-risk pregnanciesPreeclampsiaPregnancyThrombosisUltrasound imaging ePublished: 19 January 2016 Issue Published: 19 January 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...