tbuckley/cabot-search huggingface dataset:
THE TREATMENT OF HAY FEVER AND POLLEN ASTHMA BY AIR-CONDITIONED ATMOSPHERE
Authors: LESLIE N. GAY
Journal: JAMA (1933)

Through the kindness of the Frigidaire Division of General Motors, the opportunity was afforded to study the effect of air-conditioned atmosphere on individuals suffering with symptoms of hay fever and pollen asthma. A room large enough to accommodate four bed patients was equipped with a Frigidaire air-conditioning unit. The room had five windows, and a door opened on the corridor of the Osler Clinic. These windows and the door were kept closed but not sealed; consequently outside air entered the room under the door, through the cracks of the windows, and through the door when it was opened during the routine care of patients. Air conditioning, when applied to enclosures for human occupancy, may be defined as the adjustment of temperature, humidity and moisture to provide comfort and health. In summer the temperature and the relative humidity must be lowered; in the winter the temperature and the relative humidity must
From the Secretary of Health and Human Services
Authors: Louis W. Sullivan
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Possible Association Between Zika Virus Infection and Microcephaly — Brazil, 2015
Authors: Lavinia Schuler-Faccini, Erlane M. Ribeiro, Ian M.L. Feitosa, Dafne D.G. Horovitz, Denise P. Cavalcanti, André Pessoa, Maria Juliana R. Doriqui, Joao Ivanildo Neri, Joao Monteiro de Pina Neto, Hector Y.C. Wanderley, Mirlene Cernach, Antonette S. El-Husny, Marcos V.S. Pone, Cassio L.C. Serao, Maria Teresa V. Sanseverino
Journal: MMWR Morbidity and Mortality Weekly Report (2016)
(25) Sarcoid of nose with collapse of nasal cartilage
Authors: B.R. Allen
Journal: British Journal of Dermatology (1978)

Journal Article (25) Sarcoid of nose with collapse of nasal cartilage Get access B.R. Allen B.R. Allen General Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue s16, 1 December 1978, Pages 54–56, https://doi.org/10.1111/j.1365-2133.1978.tb15247.x Published: 01 December 1978
Hepatic injury during ketoconazole therapy in patients with onychomycosis: A controlled cohort study
Authors: R Chien
Journal: Hepatology (1997)

To evaluate the incidence, severity, and course of ketoconazole- associated hepatic injury, 211 patients with onychomycosis were randomized by a ratio of 2:1 to receive either ketoconazole (137 patients) or griseofulvin (74 patients). All of them were seronegative for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) and had no biochemical abnormality before therapy. The two groups were comparable in age, sex, and pretherapy liver biochemical tests. Liver biochemical tests were followed up biweekly for 3 months, and then at monthly intervals during the remaining course of therapy. No biochemical abnormality or hepatic injury was found in patients during griseofulvin treatment. Of the patients treated with ketoconazole, 24 (17.5%; 95% confidence interval [CI], 11.1% to 23.9%) showed asymptomatic transaminase elevation. Ketoconazole was discontinued immediately after overt hepatitis developed in another 4 patients (2.9%; 95% CI, 0.1% to 5.7%) who did not succumb to hepatic decompensation. The abnormal biochemical changes in patients with overt hepatitis returned to normal after discontinuing ketoconazole. Elderly patients were more prone to develop overt hepatitis. In patients with asymptomatic liver injury, the abnormal biochemical changes gradually returned to normal despite continuing ketoconazole therapy. The results of this cohort study suggest that ketoconazole-induced overt hepatitis is more common than previously believed and that transient subclinical injury is much more common than overt hepatitis. Therapy with ketoconazole may be continued with caution in the absence of symptoms and/or hyperbilirubinemia, but should be discontinued if overt hepatitis occurs.
Quarterly J Studies on Alcohol, New Haven
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fracture of the Month Number 27
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fade Away
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Is radical mastectomy the optimal procedure for early breast carcinoma?
Authors: C. D. Haagensen
Journal: JAMA (1967)

This question can be answered today with confidence only if four basic principles are followed in comparing case series. <h3>Precise Method of Classification.—</h3> A precise method of clinical classification must be used so that the case series being compared are truly at the same stage of advancement. We use the Columbia Clinical Classification<sup>9</sup>(Table 2) because it defines the various clinical stages of advancement of breast carcinoma more simply and precisely than any other clinical classification. In the Columbia classification, stage A is defined as follows: no grave signs of locally advanced disease, ie, edema, or ulceration of skin, or solid fixation of the tumor to the chest walls, and no clinically involved axillary nodes (other classifications refer to palpable nodes, a much less precise category). It will be noted that the size and position of the primary tumor are not factors in this classification. Stage A in the
Medical abortion.
Authors: M. Heard, J. Guillebaud
Journal: BMJ (1992)

need for long term follow up to determine whether the entity that they have defined represents an early manifestation of dementia or a benign if inconvenient consequence of growing old.'The National Institute of Mental Health's working group of which they were members published its criteria in 1986,3 and yet six years later we still do not know the answer.This information is of more than academic interest as it is bound to affect the risk:benefit ratio of any drug advocated to improve memory in elderly people.Crook and Ferris argue by analogy to presbyopia and its correction by means of lenses.A closer parallel might be the decline in physical prowess with age and its boosting with hormones.Both analogies are likely to be imperfect, and the issue is complex and unlikely to be resolved in the current state of knowledge.We do not automatically oppose the investigation of drugs to improve memory.What we want is more information about the baseline so that a more informed judgment may be made about the risks and benefits of their use.
Effect of Catatonia on Schizophrenic Mortality
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The morbidity and mortality conference (MMC) concept applied to contemporary oncology practice: Retrospective findings on management of 233 patients (pts) who died of ovarian cancer (OC), colorectal cancer (CRC) and wild-type (no identified targetable mutation) nonsquamous non-small cell lung cancer (WTLC).
Authors: Kathryn Ziel, Michael J. Birrer, J. Randolph Hecht, Heather A. Wakelee, Gigi Qiqi Chen, Margaret Ann Deutsch, Maria Eugenia Picton, Estelamari Rodriguez, Lyndsay Willmott, Gloria Kelly, Kirsten Miller, Jonathan Moss, Douglas Paley, Neil Love
Journal: Journal of Clinical Oncology (2017)

e18195 Background: MMC have traditionally evaluated pt management and potential areas for quality improvement. We hypothesized that this approach could be adapted and extrapolated to gain increased insight into how pts with common solid tumors are being treated in general oncology practice and how the approaches used align with evidence-based guidelines. Methods: 102 randomly recruited US-based general medical oncologists from a proprietary database of 4,019 agreed to consult their medical records and provide information on biomarkers assessed, systemic therapies administered and other treatment-related factors for the last pt in their practice to die from OC, CRC and/or WTLC. An IRB exemption was obtained and a modest honorarium was provided. Results: Pts with OC, CRC and WTLC received a median of 3, 3 and 2 lines of therapy, respectively, the majority of which were supported by guidelines, but in more than half of cases, the regimen administered required dose adjustment/discontinuation due to toxicity. Less than half of pts were offered trial participation and only 15 (6%) entered a trial. 19 pts with OC (25%), 25 pts with CRC (32%) and 58 pts with WTLC (73%) did not undergo BRCA, MSI and multiplex genomic testing, respectively, despite the recommendation of available guidelines. Conclusions: The MMC model may be an effective means to document variability as well as consistency in current oncologic care. Data generated via this assessment juxtaposed with current clinical evidence and available guideline recommendations could potentially serve as a powerful educational intervention. These findings require additional validation but provide initial support for future iterations of this exercise. [Table: see text]
Assessing Levels of Airborne Bioallergens in New York City
Authors: Martin Rodrigues Pereira, Edward F. Ferrand
Journal: Environmental Health Perspectives (1981)

Sampling of airborne ragweed and other pollen grains in the City of New York is described as it took place during the months of August and September 1973. Three sampling stations participated in the program. This effort was meant to serve as the forerunner of a citywide volunteer pollen sampling network based on the cooperation of existing health care providing institutions, schools, and stations of the operational sampling network of the New York City Department of Air Resources. Monitoring stations were set up on the roof of Cooper Union School of Engineering at 51 Astor Place in downtown Manhattan, at the Boyce Thompson Institute for Plant Research, Inc. at Yonkers, N.Y. and use was made of the data supplied by Middlesex General Hospital, New Brunswick, N.J. Seasonal results of ragweed pollen sampling, undertaken at the downtown New York City location of Cooper Union with the swing-shield intermittant rotoslide sampler, are similar to those of studies undertaken in the 1940's and 1950's with the Durham slide sampler in the New York metropolitan area. Comparison of the collected data with converted data obtained in 1979 at Long Island Jewish-Hillside Medical Center with the aid of a Durham gravity slide sampler shows the trend similarity of the data collected by us in 1973 and those obtained in 1979. Collected data of the 1973 ragweed season were supplied to the New York City news media on a daily basis, as a much appreciated service to the public.
Antiallergic activity of topical lodoxamide on in vivo and in vitro models
Authors: G. Ciprandi, S. Buscaglia, A. Catrullo, F. Paolieri, A. M. Riccio, N. Fiorino, G. W. Canonica
Journal: Allergy (1996)

Lodoxamide is an antiallergic drug acting as a mast-cell stabilizer, which is effective in the treatment of allergic conjunctivitis. The study aimed to evaluate the effect of lodoxamide eye-drops on the inflammatory early-phase reaction (EPR) changes induced by allergen-specific conjunctival challenge (ASCC). This was a cross-over, double-blind, placebo-controlled, randomized study, including 10 outpatients suffering from allergic rhinoconjunctivitis due to Parietaria judaica. Patients received one drop of lodoxamide tromethamine 0.1% or placebo 30 min before each ASCC. Clinical evaluation and cytologic assessment were done at baseline and 30 min after each ASCC. Lodoxamide induced a reduction in total symptom score and hyperemia during the EPR (P < 0.05). Lacrimation, itching/ burning, and eyelid swelling were only slightly (nonsignificantly) reduced. Lodoxamide induced a reduction in the total number of inflammatory cells and neutrophils during the EPR (P < 0.02). Eosinophil and lymphocyte number and ICAM-1 expression showed only a slight, not statistically significant decrease. Placebo did not affect the studied parameters. Lodoxamide reduced early clinical events and cellular changes after ASCC consistently with its activity as mast-cell stabilizer. Moreover, lodoxamide was able to downregulate in vitro ICAM-1 expression on the continuously cultured, differentiated conjunctival cell line WK. This was shown both in basal conditions (P < 0.05) and upon interferon-gamma stimulation (P < 0.03), although at high concentration.
Abstract 1393: Automated adeno/squamous-cell NSCLC classification from diagnostic slide images: A deep-learning framework utilizing cell-density maps
Authors: Mustafa I. Jaber, Liudmila Beziaeva, Christopher W. Szeto, John Elshimali, Shahrooz Rabizadeh, Bing Song
Journal: Cancer Research (2019)

Abstract Background: The most common form of lung cancer, non-small cell lung cancer (NSCLC), is further categorized into two major histopathological subtypes: ~40% Adenocarcinoma (LUAD), and ~30% squamous cell carcinoma (LUSC). Classifying patients accurately is important for prognosis and therapy decisions, but requires costly pathologist review. Here we present an automated algorithm to differentiate LUAD and LUSC diagnostic whole slide images (WSIs). Methods: 488 subtyped NSCLC high-resolution diagnostic WSIs were obtained from TCGA sources. Adjacent normal regions were identified and excluded from analysis. Cancer cell-density maps were created based on cell counts within discrete patches. These maps were then binned into ten ranges of cell counts (20-30 cells per patch, 30-40, etc. up to &amp;gt;110 cells per patch). 2D color patches were transformed into 1D descriptive vectors using the inception v3 deep learning framework. Samples were randomly split into 70% training and 30% testing sets. Ten LUAD/LUSC linear SVM classifiers (one for each cell-density bin) were trained on such transformed data. Subtype prediction in unseen testing samples was achieved by averaging subtype predictions from the 10 subsequent models. Results: 338 TCGA diagnostic WSIs (164 LUAD and 174 LUSC) were used to train, and 150 (71 LUAD and 79 LUSC) were used to test. The proposed system achieved an AUC of 0.9068 in test samples, corresponding to a classification accuracy of 83.33%. The (heretofore excluded) adjacent normal regions were classified correctly almost as accurately as tumor regions (74.7%). Conclusions: This fully-automated histopathology subtyping method generates maps of regions-of-interest within WSIs, providing novel spatial information on tumoral organization. For example, our results on test data show tumor patches of size 100 square microns with 60 to 100 cells distinguish LUAD from LUSC better than other cell-density ranges. Moreover, adjacent normal tissue may provide additional insights into tumorigenesis mechanisms. Citation Format: Mustafa I. Jaber, Liudmila Beziaeva, Christopher W. Szeto, John Elshimali, Shahrooz Rabizadeh, Bing Song. Automated adeno/squamous-cell NSCLC classification from diagnostic slide images: A deep-learning framework utilizing cell-density maps [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1393.
Mouth ulcers associated with prolonged chewing of gum containing aspirin
Authors: H. N. Claman
Journal: JAMA (1967)

Progressive ulcerations of the tongue and buccal mucosa developed in an adult man. The history indicated that the patient probably had herpetic stomatitis which healed spontaneously. However, to assuage the pain of the original disease, he chewed gum containing aspirin for at least two months, and ulcers developed secondary to local effects of the aspirin. No other cause for the ulcers was found, and they healed promptly after the gum was discontinued.
Relevance in Medical Education
Authors: Sidney P. Kent
Journal: JAMA (1970)

<h3>To the Editor:—</h3> I believe Dr. Wallach misinterprets my point about relevance in medical education. A shift in emphasis from memorizing factual information to a problemsolving approach to learning and evaluation of student progress does not imply that factual and conceptual information are no longer necessary. As the ability to use facts to solve problems requires an additional level of understanding and is essential, it should be a more valid way of evaluating student progress. It also may be a more stimulating approach to learning. The assumption that such an approach would result in pediatricians, internists, anesthesiologists, etc, who cannot deal with problems they see repeatedly, unless they have a textbook in one hand, understimates the value of working with problems as a learning experience. Dr. Wallach's pediatrician does not need flash cards of the various exanthemata probably because in his training and subsequent experience he has used his frequent
Intraperitoneal chemotherapy for gastric cancer with peritoneal metastases: A single center retrospective analysis of 71 patients
Authors: Masahiro Yoshida, Yasushi Tsuji, Maki Tanakamaru, Naoka Okamura, Junko Sugiyama, Tetsuya Sumiyoshi, Michiaki Hirayama, Naohito Yoshizaki, Hitoshi Kondo, Syunichi Okushiba
Journal: Annals of Oncology (2017)
Metabolic carotenaemia
Authors: S.A.Vaughan Jones, M.M. Black
Journal: British Journal of Dermatology (1994)

Journal Article Metabolic carotenaemia Get access S.A.Vaughan Jones, S.A.Vaughan Jones St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.M. Black M.M. Black St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 1, 1 July 1994, Page 145, https://doi.org/10.1111/j.1365-2133.1994.tb08480.x Published: 01 July 1994