tbuckley/cabot-search huggingface dataset:
Minor Comments
Journal: JAMA (2017)

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Highlights from this issue
Authors: Andrew Bush, Ian Pavord
Journal: Thorax (2012)

This issue coincides with the American Thoracic Society meeting, and we have tried to have a USA theme, showcasing work from North America to emphasise our wish to attract the best manuscripts from all round the world.These include a variety of topics: primary ciliary dyskinesia (with an attempt to recreate the cordial Anglo-American relationships extant at the time of the Boston Tea party in the correspondence columns!), COPD, interstitial lung disease and the basic science of lung development, reflecting the diversity of the Journal and the readership.
Mishaps Under Salvarsan
Journal: JAMA (1913)

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Infection after caesarean section.
Journal: BMJ (1989)

antibiotics in these high risk situations has re- peatedly been shown to reduce the incidence of subsequent infection.In the labour ward attention to basic principles of asepsis and surgery can easily fall.This is understandable for a variety of reasons, but none the less it remains unacceptable.Lessons which were learnt by our predecessors from maternal deaths in the preantibiotic era are often forgotten by junior doctors, to whom antibiotics can become the panacea of all ills.By all means let us use prophylactic antibiotics for caesarean section in patients at high risk, but at the same time let us audit the figures for our own units and make sure that they are not being used to compensate for lack of proper attention to basic obstetric, aseptic, and surgical techniques.These result in savings that cost nothing.
Serum Iso-Amylases: Electrophoretic Study of the Blood Amylase and the Patterns Observed in Pancreatic Disease
Journal: JAMA (1963)

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Drug-taking by the young.
Journal: BMJ (1967)

MEDIBCAJOUA 67 limit of safety ; most drivers would have their ability impaired at levels of 50 mg./100ml. or below.The variable effects of food taken with drink, tiredness, minor illness and remedies taken for it, and other factors, including habituation to alcohol, make it impossible to advise any "safe" upper limit for alcohol consumption before driving.The only sound rule remains: Don't mix drink and driving.
Effects Morbidity of Treatment on in Hypertension
Journal: JAMA (1970)

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CATARACTS IN ASSOCIATION WITH DERMATOLOGICAL DISORDERS
Journal: JAMA (1963)

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BBS volume 6 issue 4 Cover and Front matter
Authors: Eric Stone, H Akiskal, H Anisman, R Zacharko, M Aprison, J Hingtgen, W Berrettini, R Cohen, R Depue, ; Wb, A Frazer, Y Huang, R Katz, G Kraemer, F Petty, K Roth, L Siever, T Zelnik, M Sugrue, J Vetulani, Robert Wilensky, R Abelson, ; Jf, C Bereiter, J Black, W Brewer, T Carr, T Van Dijk, M Dyer, A Graesser, J Keenan, Denver Discourse, W Lehnert, J Mandler, J Marshall, M Martin, D Parisi, C Perlis, J Pleh, I Laszlb, T Siklaki, P Terestyeni, S Sgall, Sperber Small, N Stein, ; Dl, M Dorfman, Stephen Grossberg, L Arend, B Bridgeman, H Buffart, T Caelli, S Coren, J Foley, ; Dh, Foster Wj, Wel Grimson, T Indow, D Laming, D Levine, ; Se, M Shaw, James Dinsmoor, P Badia, Abbott Mn
Journal: Behavioral and Brain Sciences (1983)

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THE DAVID LIVINGSTONE MEDICAL COLLEGE IN LONDON.
Journal: JAMA (1893)

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The Kokopelli
Authors: Alfred Vogl
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In his article "Kokopelli of Indian Paleology" (<b>212</b>: 1678, 1970), Dr. Wellman finds the diagnosis of Pott's disease unlikely to account for the gibbus of the Kokopelli since it would appear incompatible with their liveliness, their physical fitness, their role as medicine men, the depicted location of a gibbus in the lumbosacral region, and the paralysis of the legs which is apparent on some of these pictures (Figure). May I draw attention to the fact that all this is not uncommonly found in achondroplastic dwarfs?<sup>1,2</sup>They are known for their strength and skill (many of them have been famous as circus clowns), their intelligence and wit (medieval paintings show them as court jesters), and they have enjoyed the reputation of having unusual sexual prowess. Many of the achondroplastic dwarfs have a prominent dorsolumbar gibbus, and quite a few develop paraplegia later in life due to the
Editorial Board
Authors: Jeffrey Bernhard, Thomas Cropley, Karen Wiss, Melissa Derby, Ponciano Cruz, Texas Medicine, Jane Grant-Kels, Connecticut Dermatopathology, Nathaniel Jellinek, Rhode Island, Timothy Johnson, Ann Arbor, Alexandra Kimball, Marta Petersen, David Rubenstein, Chapel Hill, Martin Weinstock, Suddhasatta Acharyya, Leah Belazarian, Michael Bigby, Jean Bolognia, New Haven, Luis Diaz, Carolina Lebwohl, New York, Donald Miech, Wisconsin Ginat, W Mirowski, Scott Norton, Maryland Olsen, Carolina Orringer, Amy Paller, J Smith, Richard Dobson
Journal: Journal of the American Academy of Dermatology (2007)
Abstract 725: Protein Kinase C delta Inhibits Type I Collagen Basal Expression through CCAAT-binding Factor and c-Krox in Vascular Smooth Muscle Cells
Authors: Kentaro Kamiya, Andrew Zohlman, Amy Rapp, Chunjie Wang, K. Craig Kent, Bo Liu
Journal: Circulation (2007)

Protein Kinase C delta (PKCδ) regulates multiple functions in vascular smooth muscle cells (VSMCs) including proliferation, migration, and apoptosis. In previous studies, we have demonstrated that PKCδ activity is necessary for TGFβ-induced fibronectin production in VSMCs. The purpose of the current study is to understand the role of this kinase in regulation of type I collagen synthesis. Using A10 VSMCs derived from rat thoracic aorta, we showed that TGFβ (5ng/ml x 48 hours) increased type I collagen expression. Pretreatment of A10 with Rottlerin (2uM, 1 hour), a selective inhibitor of PKCδ, dramatically increased type I collagen basal expression independent of TGFβ. To understand the mechanism involved with PKCδ, we used a Luciferase reporter that contains the human COL1A2 promoter (−772 to +58). Rottlerin stimulated the Luciferase reporter activity by 3.53±0.13 fold (n=3, p&lt;0.01). Moreover, inhibition of PKCδ with a dominant negative mutant led to upregulation of reporter activity (1.77±0.15 fold induction, n=3, p&lt;0.01), while activation of PKCδ with a constitutive active mutant reduced collagen reporters (0.19±0.02 fold reduction, n=3, p&lt;0.01). Using a series of 5′ deletions of COL1A2/Luciferase constructs (−772, −353, and −108), we narrowed the location of the PKCδ-response element to the -108/+58 region of the COL1A2 promoter, which is distinct from the TGFβ response element that is further upstream. This region contains a CCAAT motif and a c-Krox motif that have been previously implicated in collagen expression. Using a gel shift assay, we found that inhibition of PKCδ with Rottlerin or the dominant negative mutant increased the binding of CCAAT-binding Factor (CBF) to the CCAAT motif but decreased the binding at the c-Krox site. Taken together, our data indicate that PKCδ inhibits type I collagen basal expression by affecting its gene transcription through a mechanism involving CBF and c-Krox in VSMCs. We believe that PKCδ is one of the key players in mediating extracellular matrix production and could contribute to pathogenesis of vascular diseases.
Safety Measures for Prevention of PCB Accidents
Authors: Jouko Pajari
Journal: Environmental Health Perspectives (1985)

This paper attempts to clarify the most common measures available for the fire and electrical engineer in the prevention of polychlorinated biphenyl (PCB) hazards. It points out the risks and the potential for making large risks involved in the use of transformers and capacitors more manageable. The focus in solving the PCB problem is on priority. This should be reflected in the agenda of the workshop: it should discuss not only transformers and capacitors as such, but deal more with questions concerning waste disposal, getting correct information to people on substances containing PCBs and on the proper and nonpanicky handling of such substances. The PCB issue does not lend itself to any black and white solution. Instead, a number of different aspects have to be taken into account. Any solutions arrived at are therefore always compromises between risk evaluation and cost effectiveness. Reduction of PCB risks does not have to result, for example, in an increase in fire risks. It is preferable to move step by step and avoid making irretractable decisions. Alternatives available for replacing PCB-filled devices or the widely used method of refilling PCB-filled transformers with silicone oils are not discussed. Refilling is not dealt with because its capacity to reduce the fire risk sufficiently in locations where these transformers are usually found in northern Europe is not known with certainty.
Growth-Related Alterations during Liver Carcinogenesis: Effect of Promoters
Authors: Per O. Seglen, Per Gerlyng
Journal: Environmental Health Perspectives (1990)

Bromodeoxyuridine labeling of DNA, binuclearity counting, and flow cytometric analysis of isolated hepatocytes and hepatocyte nuclei has been used to assess hepatocellular growth patterns related to liver carcinogenesis. Three growth patterns can be distinguished. Mononucleating growth is observed during liver regeneration and after treatment with the tumor promoter 2-acetylaminofluorene (2-AAF) and its analogue 4-AAF. In this growth mode binucleation does not occur, resulting in a decrease in the fraction of binucleated cells. Binucleating growth is observed during normal liver development and after treatment with compounds such as phenobarbital, characterized by progressive polyploidization and maintenance of a binucleated cell fraction. Diploid growth is the growth pattern of neoplastic liver hepatocytes. Most of the cells in neoplastic lesions (foci, nodules, and carcinomas) are diploid, in contrast to the normal liver. Diploid tumor cells have a much higher proliferative activity than tetraploid tumor cells, suggesting that the latter may possess a limited growth potential that makes abrogation of binucleation proliferatively advantageous.
COUNCIL ON MEDICAL SERVICE
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Task-Specific Hypoactivation in Prefrontal and Temporoparietal Brain Regions During Motor Inhibition and Task Switching in Medication-Naive Children and Adolescents With Attention Deficit Hyperactivity Disorder
Authors: Anna Smith
Journal: American Journal of Psychiatry (2006)

Objective: A relatively small number of functional imaging studies of attention deficit hyperactivity disorder (ADHD) have shown abnormal prefrontal and striatal brain activation during tasks of motor response inhibition. However, the potential confound of previous medication exposure has not yet been addressed, and no functional imaging study exists to date on medication-naive children and adolescents with ADHD. The aim of this study was to investigate the neural substrates of a range of motor and cognitive inhibitory functions in a relatively large group of children and adolescents with ADHD who had never previously been exposed to medication. Method: Nineteen boys with ADHD and 27 healthy age- and IQ-matched boys underwent functional MRI to compare brain activation during performance of tasks that assessed motor response inhibition (go/no go task), cognitive interference inhibition (motor Stroop task), and cognitive flexibility (switch task). Results: Boys with ADHD showed decreased activation in the left rostral mesial frontal cortex during the go/no go task and decreased activation in the bilateral prefrontal and temporal lobes and right parietal lobe during the switch task. No significant group differences were observed during motor Stroop task performance. Conclusion: Abnormal brain activation was observed in medication-naive children and adolescents with ADHD during tasks involving motor inhibition and task switching, suggesting that hypoactivation in this patient group is unrelated to long-term stimulant exposure. Furthermore, functional abnormalities are task-specific and extend from frontostriatal to parietal and temporal cortices.
Editorial Change.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal