tbuckley/cabot-search huggingface dataset:
Terapevticheskii Arkhiv, Moscow
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mapping of immunodominant CD4+T lymphocyte epitopes of Hepatitis C virus antigens and their relevance during the course of chronic infection*1
Authors: R HOFFMANN
Journal: Hepatology (1995)

In acute and chronic viral disease the specific response of CD4+ T lymphocytes to certain viral proteins is an essential part of antiviral effector mechanisms. In hepatitis C virus infection, the contribution of the immune system and particularly of CD4+ T lymphocytes to the pathogenesis of disease is unknown. We serially determined the peripheral blood CD4+ T lymphocyte response to several recombinant hepatitis C virus proteins (core, NS3, NS4, NS5) and 17 overlapping synthetic peptides derived from the core sequence over up to 48 months in 43 patients with chronic hepatitis C; of these, 16 had been treated with interferon alfa (IFN). Twelve of 27 untreated patients, 4 of 4 sustained responders to IFN, 7 of 8 patients with a transient response, and 1 of 4 nonresponders showed a proliferative response to hepatitis C virus proteins. The hepatitis C virus core protein was the most immunogenic protein, and fine analysis with peptides indicated amino acids 23 to 42, 66 to 85, and 131 to 150 as immunodominant regions. In a subgroup of nine patients, proliferation assays were performed before or during IFN. In this subgroup, sustained responders but not those with a transient or no response to IFN showed a specific CD4+ immune reaction to hepatitis C viral antigens (P < .05). Infection with hepatitis C virus genotype 3a was significantly associated with a sustained response to IFN (P < .05). In general, a CD4+ T lymphocyte response was more common in patients with chronic hepatitis C who responded to interferon-alpha as compared with nonresponders. Thus a strong CD4+ reaction before and during IFN therapy may be a predictor of sustained response.
Screening and treatment difficulties of hepatitis C virus infected patients with substance use disorders or dual pathology, despite centralized management in an addiction and dual diagnosis center
Authors: Cristina Marcos Fosch, Felipe Palma-Alvarez, Ariadna Rando, Constanza Daigre, Mar Riveiro Barciela, Jordi Llaneras, Marta Perea, Francisco Rodriguez Frias, Rafael Esteban, Lara Grau-López, Maria Buti
Journal: Journal of Hepatology (2020)
Migration Route
Authors: Corey D. Fogleman
Journal: Annals of Internal Medicine (2013)

Ad LibitumOctober 1, 2013Migration RouteCorey D. Fogleman, MDCorey D. Fogleman, MDFrom Lancaster, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-7-201310010-00016 Audio Reading - “Migration Route” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Migration Route," by C.D. Fogleman. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Unseen finchesIn the saltbush,Rustle like namesForgotten.Bills jutted,Mallards barrelFleetly, needingJotting.And unhurriedSandhill cranes, inFlight toSunset plenary,All neck and legAnd arc of sky,Have eleganceLike memory. Author, Article, and Disclosure InformationAffiliations: From Lancaster, Pennsylvania.Current Author Address: Corey D. Fogleman, MD; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Migration Route” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Migration Route," by C.D. Fogleman. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics October 1, 2013Volume 159, Issue 7Page: 501KeywordsMemory ePublished: 1 October 2013 Issue Published: October 1, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Multicentric reticulohistiocytosis
Authors: M.O. COUPE, S.J. WHITTAKER, N. THATCHER
Journal: British Journal of Dermatology (1987)

A case of multicentric reticulohistiocytosis associated with a pleural mesothelioma is reported. The cutaneous and joint manifestations resolved after treatment with cyclophosphamide, and the remission persisted until the patient's death 3 years later. As corticosteroids have such an unpredictable effect on this condition, cyclophosphamide may be regarded as the treatment of choice until more cases can be assessed.
Commentary
Authors: P McCrory
Journal: British Journal of Sports Medicine (2001)

Professional and amateur participants in many sports are at risk of brain injury caused by impact with other players or objects.In many cases, mild cognitive deficits may persist after the common neurological signs of brain injury have passed.In recent years, the athlete's cognitive status after concussion has been measured with conventional "paper and pencil" neuropsychological tests.However, such tests are not ideal for sporting settings, as they are designed for the detection of gross cognitive impairments at a single assessment, not for the identification of mild cognitive deficits on repeated assessment.A number of computerised cognitive assessment tests and test batteries have been developed over the past two decades.These batteries oVer major scientific and practical advantages over conventional neuropsychological tests which make them ideal for the assessment of cognitive function in sportspeople.This review first describes the problems associated with cognitive assessment of people with sports related cognitive deficits, and then critically examines the utility of conventional neuropsychological and computerised cognitive tests in sporting settings.
Essential Malariology
Authors: Yezid Gutierrez
Journal: JAMA (1981)

This book covers all of the basic principles of malaria as a disease and its control in endemic areas. It contains chapters on the history, parasites, clinical course, pathology and immunology, diagnosis, the<i>Anopheles</i>vector, epidemiology, chemotherapy, bases for control, and eradication. Each one of these chapters is written in an authoritative, lucid, concise manner, which only a writer with the experience of Dr Bruce-Chwatt can do. In addition, there is a list of 381 selected references, including most of the World Health Organization publications on malaria, and several appendices with tabulated data on drugs, insecticides, and malaria risk by country. The wealth of information presented in this medium-sized book is very well treated and organized. The eager student of parasitology, public health, or epidemiology, as well as the specialist in infectious or tropical diseases will find it a source of up-to-date information on malaria. However, the main emphasis of
Smokeless Tobacco Use in the United States
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Smokeless Tobacco Use in the United States Get access JNCI: Journal of the National Cancer Institute, Volume 81, Issue 19, 4 October 1989, Page 1522, https://doi.org/10.1093/jnci/81.19.1522 Published: 04 October 1989
The performance of a digital blood pressure monitoring device
Authors: J. M. Watkins-Pitchford
Journal: JAMA (1989)

<h3>In Reply. —</h3> We congratulate Coles et al on the innovative use of discharge diagnosis data, and we agree with the conclusion that the polysaccharide<i>Haemophilus</i>vaccine provided protective efficacy in children aged 24 to 59 months. A randomized trial of the vaccine in Finland<sup>1</sup>as well as three postlicensure case-control studies<sup>2-4</sup>all demonstrated a protective effect of the vaccine. Only one study,<sup>5</sup>a small case-control study with wide confidence limits, suggested a lack of efficacy. Although surveillance data can provide important supporting evidence of efficacy, there are methodological difficulties in using surveillance data to estimate the efficacy of a vaccine, as can be seen in the data presented by Coles et al. Year-to-year variation during the period of 1980 to 1984, when no vaccine was available, was substantial for the two younger age groups, 0 to 23 and 24 to 59 months of age. In fact,
Clinical Evidence
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preventive medicine and public health
Authors: W. Foege
Journal: JAMA (1995)

Four themes have dominated the evolving public health landscape, each providing a blend of pride and apprehension. Scientific advances continue to astound while human failings continue to confound. The first evolving theme is the field of infectious disease. Infectious disease control was once synonymous with public health. The decreasing role it played as chronic disease and environmental and occupational health problems were expanding is being reversed. New tools, advances, and abilities must be weighed against worrisome setbacks. The advances are momentous. A second disease is nearing eradication, with dracunculiasis cases decreasing from an estimated 3.5 million in 1986 to 150 000 in 1994, a decrease of 95%.<sup>1</sup>This hemisphere has gone 3 years without a case of polio caused by wild virus strains, China is on the brink of polio eradication, and global eradication will occur before the end of the decade, making it the third human disease to
Can aldose reductase inhibition ameliorate diabetic neuropathy?
Authors: E. R. Gonzalez
Journal: JAMA (1981)

Aldose reductase, the enzyme "highest up" on the polyol pathway, may play a crucial role in the development of diabetic neuropathy. At the recent meeting of the American Diabetes Association in Cincinnati, a team of investigators headed by Roman Judzewitsch, MD, reported that pharmacologic inhibition of that enzyme significantly increased motor nerve conduction velocity in a group of 36 diabetic patients. Some of the patients were evaluated at the University of Chicago-Pritzker School of Medicine and others at the University of Washington School of Medicine in Seattle. The agent used to accomplish the inhibition was sorbinil, an experimental drug manufactured by Pfizer Laboratories. In an interview with<i>JAMA</i>MEDICAL NEWS, Judzewitsch's co-worker, Daniel Porte, Jr, MD, director of the Diabetes Research Center and professor of medicine at the University of Washington, explained that at the initiation of the study all patients were hyperglycemic on stable diabetic treatment regimens. No patient
HUMAN CARRIERS OF TETANUS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Occupational acroosteolysis. Report of 31 cases
Authors: R. H. Wilson
Journal: JAMA (1967)

In 31 cases of acroosteolysis of the hands of workmen associated with vinyl chloride (CH CHCI) polymerization processes, the osteolysis was specific to the distal phalanges of hands and was frequently associated with Raynaud's symptoms. Affected personnel ranged in age from 26 to 47. The disorder is believed to have resulted from a combination of physical insult, chemical insult, and personal idiosyncrasy. The specific causes are unknown. The prevalence was found to be less than 3% among employees performing similar work. No cases were found in workmen using or processing the polymer or manufacturing commercial resins.
Table of Contents
Authors: Jenny Murase, Misha Heller, Daniel Butler, ; Tucson, Raegan Hunt, Seth Orlow, Julie Schaffer, New York, Breanne Terakedis, Christopher Anker, Sancy Leachman, Robert Andtbacka, Glen Bowen, William Sause, Kenneth Grossmann, Tawnya Bowles, R Noyes, Ying Hitchcock, Kenneth Boucher, Dennis Shrieve, Salt Lake, Sultan Mirzoyev, Richelle Knudson, Kurtis Reed, Jennifer Hou, Christine Lohse, Marcus Frohm, Jerry Brewer, Clark Otley, Randall Roenigk, Astrid Blom, Shailender Bhatia, Stephanie Pietromonaco, Karen Koehler, Jayasri Iyer, Kotaro Nagase, Kelly Paulson, Daniel Sabath, Paul Nghiem, ; Seattle, Washington Kricker, Bruce Armstrong, D Phil, Vibeke Hansen, Alan Watson, Gurpreet Singh-Khaira, Christophe Lecathelinais, Dess De, Mathe´matiques Applique´es, Chris Goumas, Afaf Girgis, ; Sydney, Gyeong-Hun Park, Sung Chang, Hyun Won, Mi Lee, Jee Choi, Kee Moon, Jong Han, Su Park, Jae-Joong Kim, Jae Lee, Sung-Gyu Lee, ; Seoul, Walter Gubelin Harcha, Julia Barboza Martı ´nez, Tsen-Fang Tsai, Kensei Katsuoka, Makoto Kawashima, Ryoji Tsuboi, Allison Barnes, Geraldine Ferron-Brady, Dushen Chetty, ; Santiago, Mira Choi, Min Kim, Song Park, Hun Park, Jin Jo, Hyun Cho, Ji Lee, Kyung Park, Hee Shin, Jin Kang, Ohsang Kwon, J Am, Acad Dermatol, Monica Napolitano, Giorgio Annessi, Maurizio Nudo, Riccardo Bono
Journal: Journal of the American Academy of Dermatology (2014)
PUBLIC SPEAKING
Authors: John H. Schaefer
Journal: JAMA (1953)

<h3>To the Editor:</h3> —The letter by Dr. John Gardiner on the use of the microphone published inThe Journal(<b>151</b>:1369 [April 11] 1953) is excellent. It does not, however, mention certain other important factors and comments only in passing on reverberations. These factors are highly important whether one is speaking with or without a public address system. Every auditorium has unique acoustic characteristics. Acoustics may be improved by acoustic tile, plaster, and/or drapes. Even with these, few auditoriums approach perfection; nearly all require study by the speaker, if he is to make himself understood. Poor acoustic characteristics are the result of reflection of sound (the speaker's voice) from one surface to another in the auditorium so that the speaker's voice reaches the auditor's ear out of phase with one or more reflections from one or more surfaces. The resulting interference causes a frequently unintelligible jumble of sound. Nearly 30
Leads from the MMWR. Occupational asthma from inhaled egg protein--Iowa
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Passage of amino acids and glucose across the blood-brain barrier in patients with hepatic encephalopathy
Authors: G Knudsen
Journal: Hepatology (1993)

We repeatedly measured blood-brain barrier passage of phenylalanine, leucine, glucose and GABA in nine patients with hepatic encephalopathy using the intravenous double-indicator technique. Controls were four patients without liver disease and two of the patients who had recovered completely from their hepatic encephalopathy. The corrected cerebral venous output curves were fitted by use of a three-compartment model with four parameters. In the patients with hepatic encephalopathy, the permeability-surface area products for phenylalanine and leucine from the blood to the brain and from the brain interstitial fluid to the intracellular compartment, the unidirectional extraction and the brain amino acid influx were similar in the two groups. The permeability from the brain back to blood for phenylalanine was decreased by 72% in patients with hepatic encephalopathy compared with that in the control group (p < 0.05), whereas no difference was seen for leucine. The permeability from the brain back to the blood for phenylalanine decreased with coma grade and normalized in the two patients who recovered. Correspondingly, the calculated brain interstitial fluid concentration of phenylalanine was increased in the patients with hepatic encephalopathy. The transfer variables for bloodbrain barrier passage of glucose were similar in the two groups. The permeability from the blood to the brain for GABA was very low in both the patients with hepatic encephalopathy and the control group. We conclude that in hepatic encephalopathy the permeability from brain to blood for phenylalanine decreases with coma grade. The decrease is caused by an increased interstitial fluid concentration of the amino acid. No evidence was found of general or selective blood-brain barrier disturbance in hepatic encephalopathy. (HEPATOLOGY 1993;17:987–992.)
Benzodiazepine Prescription Regulations-Reply
Authors: Richard M. Glass
Journal: JAMA (1992)

<h3>In Reply.</h3> —Although Dr Sampson's descriptions of the inconvenience involved in writing triplicate prescriptions will resonate for many physicians, I wonder whether a majority of them would agree that the nuisance factor is really "the major issue for physicians." Many of his complaints could be addressed by procedural changes and would be eliminated by electronic point-of-sale prescription surveillance systems. Changes in surveillance methods could decrease the inconvenience for physicians but would not remove the need to balance concerns about confidentiality, stigma, and the freedom to prescribe appropriate treatment against attempts to control inappropriate prescriptions and diversion. These issues are carefully considered in a recent<i>JAMA</i>article from the National Institute on Drug Abuse.<sup>1</sup>
Endoscopy
Authors: Edward B. Benedict
Journal: New England Journal of Medicine (1949)

PROGRESS in endoscopy during the past two years has been marked by an improvement in diagnostic methods. These, in turn, have been aided by the use of new instruments. It seems fitting that this article should be devoted to a survey of the technical advances and to a re-emphasis of some of the important aspects of endoscopy.BronchoscopyThis is such a well established procedure in the diagnosis and treatment of bronchopulmonary disease that one might think there would be little that was new to report. However, improved technic by the use of the Broyles‡ bronchoscope makes the introduction of . . .
The Influence of Bone and Blood Lead on Plasma Lead Levels in Environmentally Exposed Adults
Authors: Mauricio Hernandez-Avila, Donald Smith, Fernando Meneses, Luz Helena Sanin, Howard Hu
Journal: Environmental Health Perspectives (1998)

Transgenic mouse models have emerged as plausible alternatives to long-term bioassays for carcinogenicity. Three transgenic lines evaluated to date have shown a clear capability to discriminate between carcinogens and noncarcinogens, using long-term bioassay results as the standard. The data also suggest that the transgenic lines will not fully duplicate long-term bioassay results. It is proposed that these models do not respond to chemicals that have induced highly restricted species or strain-specific tumor responses in mice or rats. Rather, the value of the transgenic models is predicated on a preferential response to transspecies carcinogens (i.e., those positive in both rats and mice, often including tumors in the same tissues). Thus, although results in transgenic models may not be completely concordant with long-term bioassays, the data can be used effectively in chemical and drug safety assessments. Further, it is proposed that validation of the models is readily achievable via ongoing studies. Validation of any alternative model is best achieved by sufficient mechanistic understanding of the model to reasonably predict the outcome of bioassays conducted in the models and use all available information on the drug or chemical. This goal can now be met with the transgenic mouse lines.