BACTERIAL VERSATILITY
Authors: H. J. L. M.
Journal: Annals of Internal Medicine (1952)

Editorial1 January 1952BACTERIAL VERSATILITYH. J. L. M.H. J. L. M.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-1-196 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe marvellous adaptability of living creatures has long excited the awe and wonder of the natural philosopher; recently it has stirred less reverent thoughts in the minds of modern therapists.A few years ago in these columns attention was drawn to the appearance of bacterial resistance.1 Since that time we have encountered numerous variations on the resistance theme, and, what is more significant, we have learned that "resistance" is only the bottom rung of bacterial evasion. The disturbing situation has been excellently reviewed by Garrod in a recent lecture and published article.2Since Ehrlich led the way it has been...1 Editorial: Acquired resistance to antibiotics, Ann. Int. Med. 27: 317, 1947. LinkGoogle Scholar2 Garrod LP: Reactions of bacteria to chemotherapeutic agents, Brit. M. J. 1: 205, 1951. CrossrefMedlineGoogle Scholar3 Dunlop EM: Gonorrhoea and sulphonamides, Brit. J. Ven. Dis. 25: 81, 1949. MedlineGoogle Scholar4 MillerBohnhoff CPM: Studies on the action of penicillin. IV. Development of penicillin resistance by gonococcus, Proc. Soc. Exper. Biol. and Med. 60: 354, 1945. CrossrefMedlineGoogle Scholar5 MillerBohnhoff CPM: Studies on the action of penicillin. VI. Further observations on the development of penicillin resistance by meningococci in vitro, J. Infect. Dis. 81: 147, 1947. CrossrefMedlineGoogle Scholar6 SeslerSchmidt CLLH: Studies on sulfonamide-resistant organisms. II. Comparative development of resistance to different sulfonamides by pneumococci, J. Pharmacol. and Exper. Therap. 75: 356, 1942. Google Scholar7 Eriksen KR: (quoted by Garrod), Acta path. et microbiol. Scandinav. 23: 498, 1945. CrossrefGoogle Scholar8 Gezon HM: Antibiotic studies on beta hemolytic streptococci, Proc. Soc. Exper. Biol. and Med. 67: 208, 212 and 215, 1948. CrossrefMedlineGoogle Scholar9 DowlingHirshO'Neil HFHLCB: Studies on bacteria developing resistance to penicillin fractions X and G in vitro and in patients under treatment for bacterial endocarditis, J. Clin. Investigation 25: 665, 1946. CrossrefMedlineGoogle Scholar10 LevinsonGriffithPearson DCGCHE: Antibiotics in management of staphylococcal endocarditis; with special reference to increasing bacterial resistance, Calif. Med. 74: 167, 1951. MedlineGoogle Scholar11 FinlandMurrayHarrisKilhamMeads MRHWLM: Development of streptomycin resistance during treatment, J. A. M. A. 132: 16, 1946. 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CrossrefMedlineGoogle Scholar36 MeadsRoweHaslam MWPNM: Alterations in the bacterial flora of the throat during oral therapy with aureomycin, Arch. Int. Med. 87: 533, 1951. CrossrefGoogle Scholar37 LipmanCossBoots MOJARN: Changes in bacterial flora of the throat and intestinal tract during prolonged oral administration of penicillin, Am. J. Med. 4: 702, 1948. CrossrefMedlineGoogle Scholar38 SmithBloomfield JWAL: The effect of penicillin on the aerobic bacterial flora of the normal throat, Stanford M. Bull. 6: 469, 1948. MedlineGoogle Scholar39 Fleming A: On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. influenzae , Brit. J. Exper. Path. 10: 226, 1929. Google Scholar40 ChristieGarrod RVLP: A review of the work of a penicillin therapeutic research unit, Brit. M. J. 1: 513, 1944. CrossrefMedlineGoogle Scholar41 JawetzGunnisonSpeckColeman EJBRSVR: Studies on antibiotic synergism and antagonism. The interference of chloramphenicol with the action of penicillin, Arch. Int. Med. 87: 349, 1951. CrossrefGoogle Scholar42 RobbinsTompsett WCR: Treatment of enterococcal endocarditis and bacteremia. Results of combined therapy with penicillin and streptomycin, Am. J. Med. 10: 278, 1951. CrossrefMedlineGoogle Scholar43 Woodward TE: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMicrobial Suprainfection: Recognition and ManagementRight-sided bacterial endocarditis and endarteritisPATHOGENESIS OF CANDIDA ALBICANS INFECTION FOLLOWING ANTIBIOTIC THERAPY ITHE DISTURBANCE OF THE NORMAL BACTERIAL ECOLOGY BY THE ADMINISTRATION OF ANTIBIOTICS WITH THE DEVELOPMENT OF NEW CLINICAL SYNDROMES*DAVID T. SMITH, M.D., F.A.C.P. 1 January 1952Volume 36, Issue 1Page: 196-202 ePublished: 1 December 2008 Issue Published: 1 January 1952 PDF downloadLoading ...