tbuckley/cabot-search huggingface dataset:
Viral infections and the development of asthma.
Authors: F D Martinez
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The possible role of viral infections in the inception of asthma has been the matter of considerable debate. Older data suggested that viral respiratory infections occurring during early life could alter the lungs and the immune system, thus starting the process leading to allergic sensitization and persistent bronchial responsiveness. More recent studies suggest that infants who wheeze belong to two distinct groups, which at present can only be differentiated by the evolution of their illness. Most of these infants have a transitory tendency to wheeze during viral infections, and their lung function shortly after birth is significantly lower than that of infants who will not wheeze during similar infections. Most of these children become symptom-free during the preschool years, and their condition is not associated with higher serum IgE levels. A smaller group of children who wheeze as infants will still have wheezing episodes during the early school years. The factors that determine which infants will become persistent wheezers are not well understood, but viral infections per se are likely to play a minor role, if any. Early sensitization to aeroallergens in subjects genetically predisposed to having high serum IgE levels seems to be the main risk factor for this condition.
Emergency Fiction
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delayed Supply of Influenza Vaccine and Adjunct ACIP Influenza Vaccine Recommendations for the 2000-01 Influenza Season
Journal: JAMA (2000)

ANNUAL VACCINATION AGAINST INFLUenza is the primary means for minimizing serious adverse outcomes from influenza virus infections.These infections result in approximately 20,000 deaths and 110,000 hospitalizations per year in the United States. 1 The amount of trivalent inactivated influenza vaccine produced for distribution in the United States has increased substantially; in 1999, four manufacturers produced a combined total of 80 to 85 million doses.For the 2000-01 influenza season in the United States, lower than anticipated production yields for this year's influenza A(H3N2) vaccine component and other manufacturing problems are expected to lead to a substantial delay in the distribution of influenza vaccine and possibly substantially fewer total doses of vaccine for distribution than last year.A more precise estimate of the vaccine supply will be available as production progresses during the summer.Because many vaccine providers currently are planning their fall vaccination activities, CDC and the Advisory Committee on Immunization Practices (ACIP) are issuing adjunct influenza vaccination recommendations beyond those made by ACIP on April 14, 2000. 1 The adjunct recommendations are specific to the 2000-01 influenza season.
Do the Poor Sue More?
Authors: Helen R. Burstin
Journal: JAMA (1993)

<h3>Objective.</h3> —To evaluate whether socioeconomic status is associated with risk of malpractice claims, particularly among those who have suffered medical injury. <h3>Design.</h3> —Case-control study. <h3>Setting.</h3> —Fifty-one hospitals in New York State. <h3>Methods.</h3> —The presence and severity of medical injury, defined as disability at the time of discharge or prolongation of the hospitalization caused by medical treatment as opposed to the disease process, were assessed through review of approximately 31 000 hospital records in New York in 1984. These sampled records were then linked to formal malpractice claims. To estimate the risk of malpractice claims by age, gender, race, insurance status, and income, we conducted a case-control study of claimant cases matched with nonclaimant controls. The cases were all those patients who filed malpractice claims referring to alleged malpractice during a sampled hospitalization. Physician reviewers had previously judged the level of disability that resulted from the medical injury. Claimants (n=51) were each matched with five nonclaimant controls on the basis of injury. Noninjured cases were matched with noninjured controls and injured cases were matched with injured controls. <h3>Results.</h3> —We found that poor patients (odds ratio [OR], 0.2; 95% confidence interval [Cl], 0.03 to 0.8) and uninsured patients (OR, 0.1; 95% Cl, 0.005 to 0.9) were significantly less likely to file malpractice claims, after controlling for the severity of medical injury. Among patients who suffered medical injury, the elderly (OR, 0.2; 95% Cl, 0.03 to 0.9) were also less likely to file claims. Gender and race were not independently associated with risk of malpractice claims. <h3>Conclusions.</h3> —Poor and uninsured patients are significantly less likely to sue for malpractice, even after controlling for the presence of medical injury. Fear of malpractice risk should not be a significant factor in the decision to serve the poor. Tort reforms that would protect physicians who serve the medically indigent from malpractice suits may not be warranted. (<i>JAMA</i>. 1993;270:1697-1701)
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Miriam Cintron, Kevin Brown, Amanda Ehrhardt, Suzanne Walker, Connie Manno, Sara Billings, Timothy Gray, Paul Ruich, Catherine Copyreaders, Stephanie Alden, Jane Beckmeyer, Jan Calayag, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Brandy King, Donna Patton, Editorial Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Fanny Brown, Lenette Gardner-Gullens, Erin Kato, Peter Kim, Rachell Lozano, Michaela Mark, Caroline Sietmann, Elizabeth Scientifi, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Carrie Butt, Mary Ferkaluk, Daniel Morrow, Reuben Rios, Ronna Henry, Karen Bucher, Andy Rekito, Emily Ling, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Karen Adams-Taylor, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Marketing Thornbury, Tricia Classifi, Thalia Moss, Susan Henning, Tiff Stevenson, Saskia Bolore, Gretchen Linder, Brian Mccartney, Christine Hearne, Rebecca Staff, David Baum, Natasha Nekola, Ron Marketing, Paul Gee, Elizabeth Solaro, Geoff Rey Flick, Rick Bell, Fergus Clare, Lindsay Dawson, Will English, Ellen Gibson, Mustafa Ishaq, Craig Mccaff Rey, Michael Mcgraw, Daniel Pickhardt, Romando Rossini, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Jordynn Farrar, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Binita Shah, Denise Steinhauser, Erin Van Dusen, Joe Advertising, Production Services, Kim Boler, Rhonda Brown, Fin Carter, Daniel Degroot, Shawn Hansen, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Noemi Rivera, Mary Sieck, Sarah Subramanian, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Dan Blazer, North Carolina, David Braff, La Jolla, Stephen California, Washington Dager, Atlanta Druss, Susan Georgia, New Essock, New York, Ellen York, James Frank, Maryland Harris, S Kenneth, Virginia Kendler, C Ronald, Kathleen Kessler, Maryland Merikangas, Judith Samples O'malley, Maryland Rapoport, F Charles, Myrna Reynolds, New Weissman, Charles York, St Zorumski, Shitij Kapur, Michael Owen, Fmed Sci, Naomi Wray, Roy Grinker Sr, Daniel Freedman, Jack Barchas, Joseph Coyle, Jennifer Urbano Blackford, Jennifer Laws, Woolf Nashville, Dost Öngür, Martin Paulus, Christine Konradi, Helena Chmura Kraemer, Palo Alto, Howard Bauchner
Journal: JAMA Psychiatry (2017)
Earthquake Survivors
Authors: Joan Stephenson
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Authors: M Ali, S Al-Saadi, M Amarin, May Amin, S Arees, Arun Kuimar, A Betal, A Bhattacharyya, C Bova, C Chan, L-K Chan, M Chandgadkar, S Chin, L Danou, I Daplyn, N Datta, A Dawson, J Edouart, J Elias-Jones, M Faigen, Angela Ferguson, A Ganeshalingham, J Gaughan, K Geier, H Gill, M Gohar, R Goswamy, L Handique, G Harding, S A-A Hassabo, M Hassan, M Hassonah, A Hemaya, C Ho, Anne Houston, S Huda, R Hukuimwe, Y Hussein, M Hussein, G Hussein, P Kanuga, M Karunatilaka, I Kayyali, M Khairat, Lorna Kidd, K Kilingi, S King, Krishna Kumari, A Kubba, Georgina Lamming, G Lang, A Lawson, C-L Leung, P Loong, Marion Macpherson, A Madhvani, G Manuel, G Morris, R Nadarajah, J Newnham, B Nzerem, J Papapetros, M Patchava, Y Patel, A Pathanaidu, J Peter, A Prabhu, D Pring, S Purkayastha, Radakrishna Subramaniam, S Rahman, P Randle, N Riskalla, P Robarts, A Robertson, G Robertson, A Sawdayee-Azad, S Sellappah, S Senanayake, S Shah, S Shahin, C Sharp, M Shawer, C Sikazwe, S Singh, V Sivanandan, V Sivapathasundaram, H Soltan, C Stewart, A Swamy, G Sykes, F Tarsoon, S Turner, J Van, Der Walt, R Vasant, J Watts, A Weerakkody, A De, S Wijesundere, I Wong, W-S F Wong, R Worth, Benita Wylie, J Wynn, A Zeitoun, R Zentner, C Zouves
Journal: BMJ (1981)
Cell Proliferation and Carcinogenesis Models: General Principles with Illustrations from the Rodent Liver System
Authors: Suresh H. Moolgavkar
Journal: Environmental Health Perspectives (1993)

Rates of cell proliferation, cell death, and cell differentiation affect the risk of cancer pro- foundly.An increase in cell proliferation rates leads to an increase in mutation rates per unit of time, which, in turn, leads to an increase in the risk of cancer.An increase in cell division rates relative to death or differentiation rates may lead to an increase in the population of critical target cells, which, again, leads to an increase in cancer risk.These fundamental principles are well illustrated by the rodent liver model for carcinogenesis.In this paper I briefly discuss some of the consequences of incorporating cell proliferation kinetics into quantitative models of cancer risk assessment.Consideration of cell kinetics can shed light on apparently paradoxi- cal observations, such as the observation that the administration of two different promoters may lead to the same volume fraction in the rodent liver, with one promoter giving rise to a large number of small foci and the other to a small number of large foci.Another observation that can be illuminated by a consideration of cellular proliferation kinetics is the phenomenon of the inverse dose-rate effect.It has been observed with exposure to high LET radiation and to certain chemicals that fractionation of a given total dose of the agent leads to an increased life- time probability of tumor.A biological explanation of this finding can be given in terms of the effect of the agent on cell proliferation kinetics.
Interferon and genital warts
Authors: G. Gross
Journal: JAMA (1988)

<h3>To the Editor.—</h3> The editorial by Dr Kirby<sup>1</sup>entitled "Interferon and Genital Warts: Much Potential, Modest Progress," leaves untouched some recent developments in the use of interferon for treatment of genital papillomavirus infections. We have found that low doses of recombinant interferon alpha 2a (Hoffmann-La Roche, Basle, Switzerland) or recombinant interferon alpha 2c (Thomae/Boehringer-Ingelheim, Federal Republic of Germany) (1 × 10<sup>6</sup>to 5×.10<sup>6</sup>U/d, subcutaneously) are equally potent, and perhaps even more potent, than high-dose treatment (18 × 10<sup>6</sup>U/d) and that they cause fewer side effects.<sup>2,3</sup>In addition, when administered cyclically (for seven days followed by a therapy-free interval of four weeks, repeated approximately three times), low-dose interferon is highly effective with only minimal side effects.<sup>3</sup>With cyclic treatment, neutralizing antibodies against interferon are only rarely observed (one of 23 patients with genital warts treated with recombinant interferon alpha 2a had such antibodies
OBSTETRICAL SOCIETY OF PHILADELPHIA.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Observations on the Treatment of Asthma
Authors: T. L. Pridham
Journal: BMJ (1860)

June 9th, I stated that I considered dyspeptic asthma to be, for the most part, under the control of medical treatment, and, according to my expe- rience, by far the most frequent form of the disease.There are some further peculiarities which I have noticed in asthmatic persons, and which I would here name.First, the proportion of cases in men to women, according to my notes, is about eighty per cent. of the former.Secondly, women who are liable to asthma hesave gout prevailing in their families in a larger proportion than men; whilst in both sexes a number have both these hereditary diseases.Then, again, I have remarked that asthmatic people are, for the most part, gifted with great energy and talents far
The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis
Authors: P Adams
Journal: Hepatology (1997)

iron accumulation, age at diagnosis, presenting features, and The aim of this study was to investigate the relationprevalence of symptoms was retrospectively reviewed in 410 ship between iron overload, age, and clinical symptoms patients with genetic hemochromatosis.in genetic hemochromatosis.The relationship was studied between clinical symptoms and liver iron concentration, serum ferritin, and iron removed in a retrospective PATIENTS AND METHODS study of 410 homozygotes diagnosed using strict criteria.Hemochromatosis was diagnosed at two tertiary referral centers No significant relationship was found between liver iron between 1962 and 1995.The median year of diagnosis was 1987 in concentration, iron removed by venesection, and serum 167 Canadian patients and 1992 in 243 French patients.The diagnoferritin level with age.The prevalence of cirrhosis, diasis of hemochromatosis was established by one of the following critebetes, cardiac disease, pigmentation, and fatigue inria.(1) Liver biopsy results consistent with a histological diagnosis creased as liver iron concentration increased.The most of hemochromatosis with a hepatic iron index (hepatic iron concen- common presentations at diagnosis were fatigue or as tration/age) of ú1.9 6 (n Å 281).(2) Iron removed by venesection ther- an incidental finding in all age groups.Twenty-seven apy, ú5 g.Patients were treated by weekly venesection of 300 to 500 percent of patients (110 of 410) had no clinical symptoms mL until the serum ferritin level was approximately 50 mg/L.Iron of hemochromatosis.Iron accumulation is highly variremoved was calculated by the number of liters of blood removed to achieve iron depletion 10.5 g (n Å 53).(3) Siblings who were HLA able in patients with genetic hemochromatosis.The sigidentical and did not meet above criteria (n Å 76), including HLAnificant relationship between liver iron concentration identical siblings with elevated serum ferritin levels who did not and cirrhosis, diabetes, cardiac disease, pigmentation, undergo a liver biopsy (n Å 62) or had õ5 g of iron removed. and fatigue confirms the importance of iron toxicity inA discovered case was a patient who came to the investigators' From the
Prenatal Care, Pregnancies Complicated by Diabetes
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wide interpatient variations in gentamicin dose requirements for geriatric patients
Authors: D. E. Zaske
Journal: JAMA (1982)

Substantial interpatient variations were demonstrated in the daily doses required to obtain therapeutic gentamicin sulfate serum concentrations in 417 elderly patients. Dosages ranged from 0.3 to 22.0 mg/kg/day in patients with a normal serum creatinine level. Twenty-five percent of these patients required daily doses higher than the standard regimen of 5 mg/kg/day, and 33% required less than 3 mg/kg/day. The drug half-lives in these patients ranged from 0.3 to 32.7 hours, compared with previous reports of 2.5 to four hours. The distribution volumes of these patients ranged from 0.07 to 0.53 L/kg, compared with reported values of 0.20 to 0.25 L/kg. These wide variations in kinetic variables in elderly patients and the need to obtain narrow ranges in serum concentrations required measuring serum concentrations and individually calculating each patient's dosage requirement early in the treatment course. Doing this consistently produced optimal peak and trough serum levels. Ototoxicity did not occur in any of the patients, and nephrotoxicity may have been drug related in 2% of the elderly patients. (<i>JAMA</i>1982;248:3122-3126)
Doctors' Daughter
Authors: Julia E. McMurray
Journal: Annals of Internal Medicine (1999)

On Being a Doctor3 August 1999Doctors' DaughterJulia E. McMurray, MDJulia E. McMurray, MDUniversity of Wisconsin School of Medicine; Madison, WI53705 (McMurray)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-3-199908030-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail As a small child, I often stood on the stairway in my home, looking up at the pictures of my mother. O.U. School of Medicine, class of1945. I counted the 69 sepia-toned faces many times, always coming back to my mother's in the oval composite photograph. My mother is one of only three women, and her countenance is serious and composed; the hair in a long, wavy cut typical of the period. In an old picture from the local newspaper, written the year before my birth, my mother is sitting at a desk, wearing a white lab coat, staring out ... Author, Article, and Disclosure InformationAffiliations: University of Wisconsin School of Medicine; Madison, WI53705 (McMurray)Corresponding Author: Julia E.McMurray, MD, Department of Medicine, University of Wisconsin Medical School,2870 University Avenue, Suite 106, Madison, WI 53705. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDoctors' Daughter Stephanie Nagy-Agren Work–Family Balance Carole Warde Metrics Cited byAdult Mother–Daughter Relationships: A Review of the Theoretical and Research LiteratureWork–Family BalanceCarole Warde, MDDoctors' DaughterStephanie Nagy-Agren, MD 3 August 1999Volume 131, Issue 3Page: 222-224KeywordsChildrenEmotionsLumbar punctureResidencyShouldersSubarachnoid hemorrhageSwimmingSyphilisThoraxVentricular tachycardia Issue Published: 3 August 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...