tbuckley/cabot-search huggingface dataset:
Presurgical evaluation of the AKT inhibitor MK-2206 in patients with operable invasive breast cancer.
Authors: Kevin Kalinsky, Joseph A. Sparano, Eleni Andreopoulou, Bret Taback, Lisa Silvia Wiechmann, Sheldon M. Feldman, Preya Ananthakrishnan, Hanina Hibshoosh, John Manavalan, Katherine D. Crew, Matthew A. Maurer, Dawn L. Hershman
Journal: Journal of Clinical Oncology (2014)

2613 Background: The PI3K/Akt signaling pathway is an important signaling pathway in breast cancer (BC). MK-2206 is the first allosteric Akt inhibitor in clinical development. The purpose of this pre-surgical study is to determine the biologic effects of MK-2206 on tumor and blood markers in newly diagnosed operable BC. Methods: In this trial, 2 doses of weekly MK-2206 were administered in pts with stage I-III invasive BC (at least T1c): first dose at day -9 and second at day -2 from surgery (goal n=30). The primary endpoint was reduction of pAktSer473. Secondary endpoints included change in downstream proteomic changes, tumor proliferation (ki-67), and blood based-markers [phospho-markers in peripheral blood mononuclear cells (PBMCs)]. To maintain tumor quality, samples were processed rapidly by a standardized protocol. Paired t-tests were used to compare biomarker changes before and after MK-2206. Results: From 8/11-3/13, 12 pts were enrolled. The mean age was 53.1 years (SD: 11.2). At diagnosis, the mean tumor size was 2.5 cm (SD: 1.1). Eight pts had HR+/HER2- BCs, 1 HR+/HER2+ BC, and 3 triple negative BCs. At 200 mg (n=4), 2 pts experienced grade III rash and/or pruritus (Table), requiring 1 pt delay to surgery for 11 days. The dose was lowered to 135 mg (n=3), with 1 pt experiencing grade III rash/pruritus. Upon dose reduction to 90 mg (n=5), 1 pt had grade III rash. In PBMCs for 2 pts treated at 200 mg, reduction was seen in pS6 [mean fluorescence intensity (pre- vs. post-MK-2206); 5034 vs. 1749] and pAKT (5595 vs. 4165), with an increase in IGFR1 (6740 vs. 8653). Biomarker assessment is ongoing. Conclusions: We observed a high rate of toxicity that resulted in study suspension despite 2 dose reductions. Preliminary biomarker analysis demonstrates MK-2206 interacts with the proposed target in vivo, with up-regulation of upstream tyrosine kinase levels. If confirmed, this may identify mechanisms in which anti-tumor activity is attenuated. Clinical trial information: NCT01319539.Toxicities. Dose level # of Pts Grade I (# of pts) Grade II Grade III 200 mg 4 Mucositis (1) Hyperglycemia (1) Mucositis (2) Rash (1) Fever (1) Hyperglycemia (1) Rash (1) Pruritus (2) 135 mg 3 Pruritus (1) Rash (1) Rash (1) Pruritus (1) 90 mg 5 Mucositis (1) Dry Skin (2) Mucositis (1) Rash (1)
Contempo 1995
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disposable Filter for Microemboli
Authors: Russel H. Patterson
Journal: JAMA (1971)

A disposable, autoclavable filter passes blood at high rates of flow without excessive hemolysis. It is constructed of polypropylene, except for the filter mesh which is made of a polyester material with a pore size of about 25μ The mean rise in the plasma hemoglobin level after four hours of recirculation of banked blood at 4 liters/min in a closed circuit in which the filter was employed was 75 mgè100 cc. Studies during cardiopulmonary bypass have shown that much particulate matter can be filtered from the perfusate which otherwise would be returned as emboli to the patient. The filter can reduce or eliminate pulmonary insufficiency which sometimes results from massive transfusion of banked blood during hemorrhagic shock.
Polytetrafluoroethylene graft survival in hemodialysis
Authors: R. Munda
Journal: JAMA (1983)

Expanded polytetrafluoroethylene (PTFE) graft fistulas are widely used as secondary vascular access for patients receiving long-term hemodialysis treatment. Sixty-seven grafts were implanted in 48 patients and followed for 12 to 51 months. Cumulative patency for all grafts at 12 months was 67% ±6%, at 24 months 50%±7%, and at 48 months 43%±9%. Graft survival rates were different when considering graft configuration and location. Forearm straight graft survival at 12 months was 35%± 13%, upper arm curved grafts 60%±19%, and forearm looped grafts 78%±7%. Complications that decreased graft survival were related to thrombosis (21%), infection (25%), and intimal hyperplasia at the venous anastomosis (34%). After reviewing our experience, we believe that the challenge of secondary vascular access has not been solved by PTFE grafts. This should stimulate the search for better grafts and techniques. (<i>JAMA</i>1983;249:219-222)
No clustering of anophthalmia occurs in England, but prevalence is higher in rural areas
Journal: BMJ (1998)

No clustering of anophthalmia occurs in England, but prevalence is higher in rural areas On p 905 Dolk et al describe a study set up to answer public concern after media allegations that clusters of babies were born with anophthalmia and microphthalmia in England and a link with pesticide exposure postulated.The results suggest little localised geographical clustering in babies born in 1988-94.However, the condition is more prevalent in rural areas and this observation requires confirmation and investigation.
Coupling Transport and Biodegradation of VOCs in Surface and Subsurface Soils
Authors: James R. Hunt, Patricia A. Holden, Mary K. Firestone
Journal: Environmental Health Perspectives (1995)

Volatile organic chemicals present at Superfund sites preferentially partition into the soil gas and may be available for microbial degradation.A simple mass transfer model for biodegradation for volatile substrates has been developed for the aerobic decomposition of aromatic and aliphatic hydrocarbons.The mass transfer analysis calculates diffusive fluxes from soil gas through water and membrane films and into the cell.This model predicts an extreme sensitivity of potential biodegradation rates to the air-water partition coefficients of the compounds.Aromatic hydrocarbons are removed rapidly while the aliphatic hydrocarbons are much slower by orders of magnitude.Furthermore, oxygen transfer is likely to limit aromatic hydrocarbon degradation rates.The model presents results that cast doubt on the practicality of using methane or propane for the co-metabolic destruction of trichloroethylene in a gas phase bioreactor.Toluene as a primary substrate has better mass transfer characteristics to achieve more efficient trichloroethylene degradation.Hence, in sites where these contaminants coexist, bioremediation could be improved.
Long term follow up after autologous hematopoietic stem cell transplantation for low grade non-Hodgkin's lymphoma
Authors: N. Laudi, M. Arora, L. J. Burns, J. S. Miller, P. B. McGlave, J. N. Barker, N. K. Ramsay, P. J. Orchard, M. L. Macmillan, D. J. Weisdorf
Journal: Journal of Clinical Oncology (2004)

6660
Something in the Air...
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIETY NEWS.
Authors: Wm. Osler
Journal: JAMA (1896)

<h3>The Association of American Medical Colleges.</h3> —The next regular meeting of the Association will be held at Hotel Aragon, Atlanta, Ga., May 4, 1896. On invitation of the American Academy of Medicine, the Association will meet with that body to discuss several papers on medical education at 9 A.M. The regular official session will be held at 4 P.M., Monday, May 4, 1896. The following program corresponding with the by-laws of the Association is proposed: <h3>ORDER OF EXERCISES.</h3> 1. Reading of minutes of previous meeting by the Secretary. Adjournment of ten minutes. 2 (a) Roll call of membership. (b) President's Address. Prof. Wm. Osler. 3. (a) Report of committee on syllabus. Drs. Howard Kelly, Perry Millard, Bayard Holmes. (b) Report of committee on preliminary education. Dr. Fletcher Ingals, Chairman. (c) Reports of other committees. 1.) Relative to constitutional amendments. 2.) Relative to by-laws. 4. Financial report of Secretary-treasurer, Dr. Bayard
Obesity is associated with altered apical left ventricular rotation: A cardiac magnetic resonance tagging study Peter G. Danias, Nicholas A. Tritos, Matthias Stuber, Carol J. Salton, Kraig V. Kissinger, Warren J. Manning. Beth Israel Deaconess Medical Center, Boston, MA, Joslin Diabetes Center, Boston, MA
Journal: Journal of the American College of Cardiology (2001)
Editorial Notes
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 98: The Association Between Manual Mode Defibrillation, Preshock Pause Duration and Appropriate Shock Delivery When Employed by Basic Life Support Paramedics During Out-of-Hospital Cardiac Arrest
Authors: Sheldon Cheskes, Morgan Hillier, Cathy Zhan, Adam Byers, P R Verbeek, Ian Drennan, Laurie J Morrison
Journal: Circulation (2014)

BACKGROUND: Pre-shock pause duration of &lt; 20 seconds is associated with improved survival after cardiac arrest. Manual mode defibrillation has been associated with the shortest duration of pre-shock pause but is largely practiced by paramedics (EMT-P) whereas defibrillator only providers (EMT-D) routinely use the defibrillator in automatic mode. OBJECTIVE: We sought to explore the relationship between manual mode defibrillation, pre-shock pause duration and shock appropriateness when defibrillation is provided by EMT-P vs. EMT-D level of providers. METHODS: We performed a retrospective review of all treated non-traumatic adult OHCA presenting in a shockable rhythm over a one year period beginning January 1, 2012. Our primary outcome measure was the proportion of manual mode shocks delivered by EMT-D’s with pre- shock pause duration of &lt; 20 secs when compared to EMT-P’s. Our secondary outcome measures were the duration of pre-, post- and peri-shock pause and the proportion of appropriate shocks (defined as correct identification and shock delivery to patients in a shockable rhythm) delivered by either level of provider. This study had a power of 90% to detect an absolute difference of 15% between provider levels in proportion of shocks delivered with pre-shock pause duration &lt;20 secs. RESULTS: Among 2019 treated OHCA, 335(20%) presented in a shockable rhythm. Manual defibrillation was performed in 155 (46%) of these cases (196 shocks by EMT-P, 143 shocks by EMT-D). There were no differences in the proportion of shocks delivered with pre-shock pause duration &lt;20 secs (EMT-P 82.8% vs EMT-D 84.8%, p =.65) nor pre-shock pause duration (sec) (median, Q1, Q3); EMT-P: 12.0 (7.0,17.0) vs. EMT-D: 11.0 (5.0,17.0), p= .13 while EMT-D had shorter peri- shock pause duration (sec) (median, Q1, Q3); EMT-P: 17.0 (12.0, 23.0) vs. EMT-D: 15.0 (9.0, 22.0), p =.03. There were no differences in the rate of inappropriate shocks (EMT-P 1.0% vs EMT-D 0.7%), p=1.0. CONCLUSIONS: Manual mode defibrillation by EMT-D’s produced similar measures of pre-shock pause when compared to EMT-P’s without increasing the rate of inappropriate shocks. More widespread use of EMT-D manual mode defibrillation may have the potential to decrease shock pause duration and improve survival.
An Automatic Diluting Buret
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cimetidine and ranitidine in duodenal ulcer
Authors: M J S Langman
Journal: BMJ (1980)

analgesic action for opiates is strong.The clinical results, while not absolutely conclusive, grow steadily more convincing as further information becomes available.The onus remains with us-that is, with clinicians and clinical investigators-to unravel the remaining uncertainties concerning these substances when used in human subjects.
Vitamin Supplementation in Health and Disease
Authors: Perry J. Culver
Journal: New England Journal of Medicine (1949)

nutritional Surveys and Subclinical Vitamin DeficiencyWith the exception of one report,68 nutritionists in general note that frank deficiency diseases, especially vitamin-deficiency diseases, have almost disappeared during the last decade in the United States.12, 72 73 74 The majority of cases of clinical vitamin deficiency now seen are in association with chronic alcoholism or some debilitating disease,72 and a moderate number of cases of scurvy occur in infants because mothers boil the orange juice or cater to dietary dislikes.75 The cause of this reduced incidence of gross vitamin deficiency in the United States is unexplained. Blankenhorn72 observes that deficiency began to disappear before . . .
Recurrence after duodenal ulcer surgery
Authors: P. Gunby
Journal: JAMA (1982)

The ulcer recurrence rate associated with the more conservative of two surgical procedures for chronic duodenal ulcers—highly selective vagotomy (HSV)— may be higher than that for the more radical procedure—truncal vagotomy and pyloroplasty (TVP). TVP was the most commonly performed surgery for chronic duodenal ulceration in Britain when a comparison trial began there in the early 1970s (<i>Br J Surg</i>1979;66:145-148). The procedure eliminates gastric acid hypersecretion by interrupting the triggering parasympathetic nerve network to the stomach, liver, gallbladder, bile ducts, pancreas, small intestine, and part of the large intestine. The pyloroplasty relieves gastric stasis. HSV involves selective dissection of the nerves to the fundus and body of the stomach, while preserving as many as possible of the vagal nerves to the antrum and pylorus. One investigator, James C. Thompson, MD, of the University of Texas Medical Branch, Galveston, recently noted that this operation "is associated with a rate of
Abstracts
Authors: J Kriegsmann, U Miiller-Ladner, A Trabandt, T Geiler, W Aicher, G Keyszer, R Gay, S Gay, Shunichi Shiozawa, Kazuo Hino
Journal: Annals of the Rheumatic Diseases (1995)

Patients with rheumatoid arthritis (RA) characteristically exhibit overlapping mani- festations of three pathobiological phenom- ena: inflammation, abnormal humoral and cellular immune responses, and synovial hyperplasia.A comprehensive histomorphological study of the spontaneous RA like disease in MRL-lpr/lpr mice has revealed the sequence of events leading to cartilage and bone destruction in the affected joints.Joint destruction occurs in the sequence: prolifera- tion of transformed appearing synovial lining cells; attachment of these cells to cartilage, apparently in association with the first steps of matrix degradation; subsequent infiltration with inflammatory cells which accelerates the destructive process.Interestingly, the trans- formed appearing synovial cells in this animal model resemble the transformed appearing synovial cells in human RA described by Fassbender.On the basis of the abnormal appearance of these cells, we searched for the expression of proliferation associated oncogenes, cell adhesion molecules, and matrix degrading enzymes at sites of joint destruction in RA.Expression of oncogenes myb, myc and ras was found in about 75% of RA patients and was largely restricted to the synovial lining cells attached to cartilage or bone.In about 50% of the RA cases the cystine proteinase, cathepsin L (a major ras-induced protein), and cathepsin B colocalised with ras ex- pression.Moreover, c-fos and egr-1 could be detected in collagenase producing cells.The interaction of synovial cells with matrix in vivo, was studied further: synovial tissue or isolated synovial lining cells derived from RA patients were implanted together with normal human cartilage into SCID mice.Double labelling techniques using in situ hybridisation, in situ polymerase chain reactions and immunocytochemistry have revealed that cathepsin D is expressed in CD68 macrophages, whereas cathepsin L is expressed in vascular cell adhesion molecule- 1-expressing fibroblast like cells.This approach provides a novel experimental model to explore the molecular and cellular mechanisms of rheumatoid destruction.
The Melanoma Problem from a New Point of View
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
After the accident, after the ambulance, what kind of care?
Authors: B. G. Montgomery
Journal: JAMA (1980)

In the past decade and a half, a network of more than 300 trauma care centers has developed as part of the national Emergency Medical Services system. The result is that standards for such care are becoming more uniform. Mortality for accidents that maim has dropped, and highway accidents and burn injuries in general have received much special attention. At the recent American College of Surgeons meeting in Chicago, a multi-day symposium on trauma care attracted much of the membership. Chairman of the symposium was Robert J. Freeark, MD, of Loyola University of Chicago's Stritch School of Medicine. Among other topics, the aftermath of high-speed collision injuries was discussed. <h3>The Contused Lung and Fluid Resuscitation</h3> "One of the big issues in trauma care is whether to use albumin for fluid resuscitation," Freeark told<i>JAMA</i>MEDICAL NEWS. "Neurosurgeons keep telling us we need albumin. But the issue is controversial. Albumin is
CURSUS HONORUM, OR HOW TO GET AHEAD IN THE MEDICAL WORLD
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal