tbuckley/cabot-search huggingface dataset:
What is the Optimal Age for Repair of Tetralogy of Fallot?
Authors: Glen S. Van Arsdell, Gyaandeo S. Maharaj, Julie Tom, Vivek K. Rao, John G. Coles, Robert M. Freedom, William G. Williams, Brian W. McCrindle
Journal: Circulation (2000)

Background —Controversy regarding the timing for the repair of tetralogy of Fallot centers around initial palliation versus primary repair for the symptomatic neonate/young infant and the optimal age for repair of the asymptomatic child. We changed our approach from one of initial palliation in the infant to one of primary repair around the age of 6 months, or earlier if clinically indicated. We examined the effects of this change in protocol and age on outcomes. Methods and Results —The records of 227 consecutive children who had repair of isolated tetralogy of Fallot from January 1993 to June 1998 were reviewed. The median age of repair by year fell from 17 to 8 months ( P &lt;0.01). The presence of a palliative shunt at the time of repair decreased from 38% to 0% ( P &lt;0.01). Mortality (6 deaths, 2.6%) improved with time ( P =0.02), with no mortality since the change in protocol (late 1995/early 1996). Multivariate analysis for physiological outcomes of time to lactate clearance, ventilation hours, and length of stay, but not death, demonstrated that an age &lt;3 months was independently associated with prolongation of times ( P &lt;0.03). Each of the deaths occurred with primary repair at an age &gt;12 months. The best survival and physiological outcomes were achieved with primary repair in children aged 3 to 11 months. Conclusions —On the basis of mortality and physiological outcomes, the optimal age for elective repair of tetralogy of Fallot is 3 to 11 months of age.
Abstract 1392: G Protein Coupled Receptor Kinase 6 Couples Stromal Cell Derived Factor-1 <i>α</i> -CXCR4 Signaling to ERK/AKT Activation in Rat Cardiac Stem Cells
Authors: Wasana Sumanasekera, Shujing Dai, Piero Anversa, Roberto Bolli, Gregg Rokosh
Journal: Circulation (2008)

Stromal cell derived factor-1 α (SDF1) through the interaction with it receptor CXCR4 plays an important role in regulating the localization and function of hematopoietic stem cells. Recently, we have described SDF1-CXCR4 signaling in the heart and found it to regulate myocardial survival through the activation of ERK and AKT. CXCR4 is known to couple to the heterotrimeric G-Protein, Gi. The G-protein receptor kinase 6 (GRK6), may serve to uncouple the receptor from downstream signaling or to facilitate signaling via phosphorylation- dependent and independent mechanisms. To further understand cardiac SDF1-CXCR4 signaling and function we used rat clonal cKit + cardiac stem cells (rCSC) to assess the role of GRK6 in CXCR4 responses to SDF1. To specifically target GRK6 actions in SDF1-CXCR4 signaling and function in rCSCs we used siRNA to knockdown GRK6 in vitro. In untreated rCSCs, GRK6 specific siRNA significantly knocked down the expression of GRK6 by 50 – 60% which lead to significant decreases in levels of P-AKT, and P-ERK (about 70 - 90% respectively, P± 0.05) and increased levels of P-JNK, P-p38, and Caveolin1 in untreated rCSC. The treatment of rCSC with 25 nM SDF1 significantly increased GRK6 expression and this increase was attenuated by GRK6 specific siRNA. AKT, ERK, JNK, and p38 phosphorylation were significantly increased 5 min after rCSC treatment with 25nM SDF1 (0.5–3 fold increase, P&lt;0.05) and GRK6 siRNA significantly attenuated SDF1activation (0.5 to 2 fold decrease, P&lt;0.05). Our results indicate that in rCSC, GRK6 is necessary for SDF1-CXCR4 dependent ERK and AKT signaling Thus in rCSCs GRK6 serves predominantly in G-protein independent SDF1-CXCR4 signaling possibly through caveolar signaling complexes. In conclusion, in rCSCs SDF1-CXCR4 interaction activates downstream ERK and AKT activation via a GRK6 dependent mechanism. These findings will be important for the understanding of SDF1-CXCR4 regulation of rCSC function.
"DR." RUTLAND IN THE TOILS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dose-Response Analysis in Animal Studies: Prediction of Human Responses
Authors: Yves Alarie
Journal: Environmental Health Perspectives (1981)

An animal bioassay has been used to evaluate a series of airborne chemicals for their sensory irritating properties to the upper respiratory tract. Teh results obtained can be used to rank their potency. An attempt has been made to predict "safe" levels of exposure for humans on the basis of this short-term assay. A good correlation was obtained between the predicted "safe" levels of exposure and current Threshold Limit Values established for industrial exposures.
Human Exposure to Tetrachloroethylene: Inhalation and Skin Contact
Authors: Carl L. Hake, Richard D. Stewart
Journal: Environmental Health Perspectives (1977)

There is considerable potential for worker exposure to tetrachloroethylene, both by skin contact and by inhalation, during its use in dry cleaning and degreasing operations. This paper reviews accounts of both accidental overexposures of workers and controlled exposures of human subjects by these two routes of exposure. Several reported cases of accidental overexposure to anesthetic doses of the chemical reveal that recovery was generally complete but prolonged, and accompanied by many days of measurable levels of the chemical in the patient's alveolar breath. Chronic overexposures of workmen have lessened since the general acceptance by the Western world of the recommended TLV of 100 ppm for 8 hr of daily exposure. Controlled inhalation studies with volunteer subjects at this level of exposure revealed no effects upon health but did indicate a slight decrement in performance on a coordination test. Additional behavioral and neurological tests revealed no interactive effects when alcohol or diazepam, two depressant drugs, were added singly to tetrachloroethylene exposures. Individual susceptibility to the vapor of this chemical, as evidenced by subjective complaints, was noted in approximately one of ten subjects. The authors conclude that the TLV concentration of 100 ppm in the workplace has a negligible margin of safety regarding unimpaired performance during repeated exposures which could be especially hazardous if the worker is physically active or is in a situation where skin absorption presents an added burden.
Infographic. Diagnosis, prevention and treatment of common lower extremity muscle injuries in sport—grading the evidence: a statement paper commissioned by the Danish Society of Sports Physical Therapy (DSSF)
Authors: Lasse Ishøi, Kasper Krommes, Rasmus Skov Husted, Carsten B Juhl, Adam Virgile, Kristian Thorborg
Journal: British Journal of Sports Medicine (2020)
DRS. JOSEPH GARLAND AND FRANZ INGELFINGER: A Splendid Heritage and a Challenge for the NEJM
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pleural Effusion
Authors: William W. Stead
Journal: JAMA (1977)

<h3>To the Editor.—</h3> In the article on pleural effusion by Storey and co-workers (236:2183, 1976), there is no notation as to the ages of the 133 patients studied. Since tuberculosis was documented in only one, I presume they were dealing largely with patients over the age of 50 years, where causes other than tuberculosis predominate. However, the age of the patients studied should always be mentioned where the causes of pleural effusion are concerned, because in persons under the age of 30 years, even today, tuberculosis has to be considered an excellent possibility when no definite cause can be determined. As it stands, without reference to age, this article may lead to confusion and cause physicians to overlook tuberculosis as the cause of an effusion in a young person, and this can have tragic consequences.
Course and Conference on Current Advances in the Epidemiology of Neurologic Disease
Journal: JNCI Journal of the National Cancer Institute (1977)

Course and Conference on Current Advances in the Epidemiology of Neurologic Disease Get access JNCI: Journal of the National Cancer Institute, Volume 58, Issue 2, February 1977, Page 467, https://doi.org/10.1093/jnci/58.2.467-a Published: 01 February 1977
Abstract 2027: Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer
Authors: Amira F. Mahdi, Beatrice Malacrida, Joanne Nolan, Kieran McGourty, Aoife J. Lowery, Patrick A. Kiely
Journal: Cancer Research (2019)

Abstract In Ireland, almost three thousand women are diagnosed with invasive breast cancer every year. This makes it the most common form of malignant tumour found in Irish females and accounts for 17% of all female cancer deaths. Although treatment for breast cancer when diagnosed early is highly effective, for those who develop late stage and metastatic breast cancer, survival rates decline rapidly. As a result, a large effort is being made to understand the mechanisms involved in the progression of breast cancer and identifying the changes that take place during the in-situ to metastatic transition. Using 2-D and 3-D in vitro models of cancer metastasis, we conducted a mass spectrometry screen to identify proteins that are newly synthesised by breast cancer cells as they migrate towards a growth factor gradient. From this screen, we identified Annexin A2 as a newly synthesised protein. Annexin A2 is a calcium-ion regulated, phospholipid-binding protein, which is involved in cell trafficking, cell-to- cell contact, cell motility and regulation of the cytoskeletal structure. Annexin A2 has been reported to be overexpressed in a range of cancers including breast cancer and has also been reported to contribute to cancer-associated processes such as proliferation, migration and chemoresistance. While investigating the role of Annexin A2 in the progression of breast cancer, our findings suggest that through modulation of the cell culture environment, subjecting cells to stress conditions and altering growth factor supplementation, that the intracellular expression of Annexin A2 remains relatively constant. However, in breast cancer patients we see dysregulation of Annexin A2 expression at a gene level, which correlates with disease progression. We are currently investigating how alterations in the composition of the extracellular environment, particularly the extracellular matrix, regulates Annexin A2 expression and cellular location. We believe that delineating the function of newly synthesised proteins such as Annexin A2 has the potential to direct novel anti-cancer therapies aimed specifically at halting the progression of breast cancer. Ultimately, these insights may lead to improvements in survival rates for those affected with this disease. Citation Format: Amira F. Mahdi, Beatrice Malacrida, Joanne Nolan, Kieran McGourty, Aoife J. Lowery, Patrick A. Kiely. Understanding the role and regulation of newly synthesized Annexin A2 in the progression of breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2027.
Characterization of aggressive breast cancer in African American and Caucasian women: Patterns of gene expression in primary breast tumors
Authors: R. Nanda, Z. Hu, X. He, M. Tretiakova, T. Grushko, F. Ikpatt, C. M. Perou, O. I. Olopade
Journal: Journal of Clinical Oncology (2004)

9513 Background: Although the incidence of breast cancer in African Americans (AA) is lower than that of their Caucasian (C) counterparts, the biology of the disease is more aggressive in these women. AA women frequently present with early onset, high-grade and hormone receptor negative disease. AA women also have a poorer overall survival, which may in part be due to the inherent biology of their disease. A major goal of breast tumor expression profiling is to identify clinically distinct subsets of breast tumors that may help to explain variability in outcome and treatment response. Unfortunately, to our knowledge, there is not a single published dataset that has included sufficient tumors from AA women to examine whether there are differences in gene expression profiles that could begin to address the disparities in health outcomes. Methods: Thus far we have prepared RNA from 30 Estrogen Receptor negative (ER-neg) breast tumors and assayed gene expression patterns using Agilent microarrays containing 17,000 different genes. We assayed 19 tumors from AA and 11 from C women and performed hierarchical clustering using our “breast tumor intrinsic” classification list as described by Perou et al., Nature 2000. Results: There were 19 AA women with an average age of 55 (range 24–84) and 11 C women with an average age of 57 (range 33–78). One half of the tumors were locally advanced breast cancers. Of the 19 tumors from AA, 10 were basal-like, 6 were Her2+, 1 was luminal and 2 were of the normal-like subtype. Of the 11 tumors from C, 5 were basal-like, 5 were Her2+, and 1 was normal-like. Based upon this supervised clustering analysis, there does not appear to be a difference between tumors from AA as compared to C. Conclusions: As expected, ER-neg breast tumors from AA are predominately of the basal-like and Her2+ expression subtypes, as has been previously reported for Caucasian women. We are now evaluating critical gene(s) that might be responsible for “driving” these subtypes of ER-neg cancer in an effort to develop more effective targeted therapies, especially for young women who are disproportionately affected by aggressive breast cancers. No significant financial relationships to disclose.
Alcohol and School Physiologies
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VOLUNTEER HEALTH INSPECTORS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Offensive Commercialism.
Authors: Arthur R. Elliott
Journal: JAMA (1904)

Chicago, January 16, 1904. <h3>To the Editor:</h3> —A few days ago I received through the mail an advertising circular from the Colorado Lithia Water Company, 167 East Van Buren Street, Chicago, and accompanying it and enclosed was a slip of pink paper neatly folded and marked "Personal." I enclose this slip and request that you publish it inThe Journalas an example of an offensive commercialism of which the entire profession must disapprove. The slip referred to reads as follows: "We will pay you $1.00 for each customer sent us or prescription ordering case or demijohn of water. (See priced card.) Cash sent you at once. "Colorado Lithia Water Co."
What You Should Know About Health and Disease.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PUBLIC-SCHOOL INSTRUCTION IN COOKING.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"EXPERIMENTAL STUDIES OF EPIDEMIC ENCEPHALITIS"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Needle aspiration biopsy technique in pulmonary disease. Application to therapy
Authors: R. A. Castellino
Journal: JAMA (1970)

<i>Pulmonary aspergillosis due to</i>Aspergillus fumigatus<i>followed cardiac transplantation in a 58-year-old man. Diagnosis was achieved by needle aspiration biopsy of a single cavitary lesion in the upper lobe of the right lung. A trial of intravenous amphotericin B therapy was unsuccessful in halting progress of the lesion. Needle aspiration of the lesion was repeated and a small polyethylene catheter was threaded into the cavity and left in place for long-term endocavitary irrigations with amphotericin B and sodium iodide. Endocavitary treatment was associated with clinical improvement and decrease in size of the lesion</i>.