tbuckley/cabot-search huggingface dataset:
Report of a Patient Treated with Anti-HIV Drugs after Receiving HIV-Contaminated Blood Who Did Not Develop HIV Infection
Journal: Annals of Internal Medicine (2000)

Summaries for Patients4 July 2000Report of a Patient Treated with Anti-HIV Drugs after Receiving HIV-Contaminated Blood Who Did Not Develop HIV InfectionSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-1-200007040-00026 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?The ability to test donated blood for human immunodeficiency virus (HIV) and routine testing has greatly decreased the risk for getting HIV infection from blood transfusions. However, there is a lag of about 3 weeks between the time a person gets infected with HIV and the time when the HIV test becomes positive. Thus, it is possible (but extremely rare) that donated blood could contain the virus even though the HIV test does not yet show it. It is also likely that treatment of patients with anti-HIV drugs ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Failure To Develop HIV Infection after Receipt of HIV-Contaminated Blood and Postexposure Prophylaxis.” It is in the 4 July 2000 issue of Annals of Internal Medicine (volume 133, pages 31-34). The authors are T.L. Katzenstein, E. Dickmeiss, H. Aladdin, A. Hede, C. Nielsen, H. Nielsen, L.B. Jørgensen, and J. Gerstoft.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFailure To Develop HIV Infection after Receipt of HIV-Contaminated Blood and Postexposure Prophylaxis Terese L. Katzenstein , Ebbe Dickmeiss , Hassan Aladdin , Adam Hede , Claus Nielsen , Helle Nielsen , Louise B. Jørgensen , and Jan Gerstoft Metrics 4 July 2000Volume 133, Issue 1Page: 31KeywordsBloodBlood transfusionDrug therapyDrugsHIVHIV infectionsHematologic testsPatientsPostexposure prophylaxisRashes ePublished: 15 August 2000 Issue Published: 4 July 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
MEDU-25. GENES PRESERVING STEM CELL STATE IN GROUP 3 MB BTICs CONTRIBUTE TO THERAPY EVASION AND RELAPSE
Authors: David Bakhshinyan, Ashley Adile, Chitra Venugopal, Mohini Singh, Maleeha Qazi, Michelle Kameda-Smith, Sheila Singh
Journal: Neuro-Oncology (2019)

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Out of all the subgroups, Group 3 patients face the highest incidence of leptomeningeal spread and overall patient survival of less than 50%. Current clinical trials for recurrent MB patients based on genomic profiles of primary, treatment-naïve tumors, provide limited clinical benefit since recurrent metastatic MBs are highly genetically divergent from their primary tumors. By adapting the existing COG (Children’s Oncology Group) Protocol for children with newly diagnosed high-risk MB for treatment of immuno-deficient mice intracranially engrafted with human MB brain tumor initiating cells (BTICs), we have characterized the rare treatment-refractory cell population in Group 3 MBs. MB cell populations recovered separately from brains and spines during the course of tumor development and therapy were comprehensively profiled for gene expression analysis, stem cell and molecular features to generate a global, comparative profile of MB cells through therapy to relapse. One of the most intriguing observations from our gene expression data was consistent over-expression of proteins belonging to Inhibitor of DNA-binding/differentiation (ID) family and a longevity associated protein bactericidal/permeability-increasing fold-containing-family-B-member-4 (BPIFB4) in our refractory population. shRNA-mediated knockdown of BPIFB4 led to markedly decreased self-renewal and proliferation of MB cells, as well as extended survival and reduced tumour burden in vivo. Furthermore, a small molecule inhibitor targeting endothelial nitric oxide synthase (eNOS), a downstream substrate of BPIFB4, impeded the growth of several MB patient-derived lines at low nanomolar concentrations. For the first time, we describe the role of BPIFB4 as a potent regulator of self-renewal and specific driver of medulloblastoma relapse. Our differential genomic and gene expression profiles of the “treatment-responsive” tumors against those that fail therapy will thus contribute to discovery of novel therapeutic targets for the most aggressive subgroup of MB.
P52 * TARGETING COLLAGEN REGULATION IN GLIOBLASTOMA MULTIFORME
Authors: F. Abaitua, T. Crook, K. O'Neill, N. Syed
Journal: Neuro-Oncology (2014)

INTRODUCTION: Extracellular matrices (ECM) are quintessential complex structures that provide cells and tissues with functional support for adhesion, migration, cell-to-cell communication and differentiation. Collagens are fibrillar proteins that constitute the major component of ECM and have a key structural role. Intracellular maturation of collagen precursors, prior to secretion, is dependent on the hydroxylation of the collagen proline residues which is mediated by the prolyl 4-hydroxylases (P4H) family of enzymes. Although, ECM and collagen prolyl-hydroxylases have been shown to be important players in cancer migration and invasion, little is known of their role in brain tumours. METHOD: To examine the role of P4H enzymes in the biology of GBM we profiled their expression in a panel of GBM cell lines a variety of techniques including RT-PCR, western blotting and MSP. For functional studies we assesed the effects of two independent inhibitors of P4H on the growth of these lines using proliferation and apoptotic assays (SRB and Annexin V respectively). RESULTS: Pharmacological inhibition of collagen prolyl-hydroxylases dramatically reduced the proliferation of a panel of GBM cell lines. This reduction was independent of apoptosis. CONCLUSION: Our preliminary results show that collagen biosynthesis plays an important role in the growth of GBM and therefore could be a potential therapeutic strategy that needs further investigation.
Update: Hantavirus Infection—United States, 1993
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accident Surgery
Authors: Robert J. Baker
Journal: JAMA (1980)

This is the third edition of this remarkable series of volumes dealing with 17 major areas in the field of surgery. The volume reviewed herein deals only with the surgery of trauma, but it addresses trauma in its broadest sense. Topics include plastic surgical repair of facial injuries and skin wounds, craniocerebral and peripheral nerve trauma, thoracic and abdominal trauma, vascular exposure and revascularization, and osseous trauma, including trauma of the hand. The format of this volume is attractive; page size is 21.6×27.9 cm (8 1/2 ×11 in), with two columns per page. Print is of intermediate size, but the text is divided into boldly numbered paragraphs, corresponding to illustrations in the adjacent column; this makes rapid review of a specific procedure a simple matter. Illustration quality is good to excellent throughout, drawings being simple but pertinent and without distracting labels. The strongest features are the excellent chapters on basic
Respiratory involvement and immune status in yusho patients.
Authors: Y Nakanishi, N Shigematsu, Y Kurita, K Matsuba, H Kanegae, S Ishimaru, Y Kawazoe
Journal: Environmental Health Perspectives (1985)

Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an early stage of the disease may be related to the fact that a number of discrete polychlorinated biphenyls (PCBs) are distributed throughout the lung parenchyma. For accumulation in the bronchial mucosa, structural requirements and specific dose dependence of PCBs have been clearly shown; however, pathological and physiological studies have indicated that respiratory involvement in yusho is mainly small airway disease that may be caused by involvement of cellular component (Clara cells) in bronchioles and/or associated infection. Respiratory distress is often exacerbated by viral or bacterial infection. Changes in the immune status in PCB and polychlorinated dibenzofuran (PCDF) poisoning are as follows: IgA and IgM in the serum are decreased at an early stage of the disease and then return to normal; suppression of cellular immunity was reported in Taiwanese patients and some may remain in the later stages of the disease, as shown in our patients. PCDFs now appear to be the main causal agents in yusho. Rats given PCDFs showed necrosis of the Clara cells in bronchioles and marked thymus atrophy, while few such changes were noted in rats given PCBs. Therefore, further examination is needed for the difference of the toxic effects between two compounds.
Intestinal permeability.
Authors: I Bjarnason
Journal: Gut (1994)

Damage to the mucosal barrier may be assessed, non-invasively by use of sugar probes, which permeate through the transcellular or paracellular (tight junction) routes. A standardised test, with analysis of a five hour urine collection has proved useful in studying the sequelae of non-steroid anti-inflammatory drug (NSAID) administration, untreated coeliac disease, and enteric infections. Choice of probe molecule is crucial and lactulose/l-rhamnose seem to be satisfactory, in contrast with polyethylene glycol. Significant correlations have been seen between permeability and plasma IgA concentrates in nephropathy, and between permeability and the passage of neutrophil chemotactic agents. The increased permeability associated with NSAID treatment may relate to the adverse effects of NSAIDs on enterocyte mitochondrial morphology and metabolism. These two factors may predispose the mucosa to permeation of bacterial chemoattractant molecules that elaborate a local inflammatory response. A similar mechanism may operate in patients with untreated Crohn9s disease, who show abnormally high permeability. Remission induced by treatment with elemental diets coincides with a reduction in permeability. The period to relapse correlated with the inability of patients to maintain low permeability to sugar probes. These results suggest a mechanism for the benefits of elemental enteral nutrients in the treatment of Crohn9s disease.
Obituary
Authors: Shutsung Liao
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1957)

COMMITTEE ON MATERNAL WELFARECholecystitis, Cholelithiasis and Coronary OcclusionA forty-one-year-old gravida 4, para 2, with a history of pre-eclampsia superimposed upon chronic hypertension in the last pregnancy was admitted a month before term. She was obese and excitable, with gall-bladder disease. The blood pressure gradually rose during the pregnancy despite scrupulous prenatal care. Her present complaint was of epigastric and precordial pain, which was diagnosed as angina pectoris and confirmed by an electrocardiogram. The blood pressure on admission was 190 systolic, 110 diastolic. There was no edema. She was treated with absolute bed rest for the first two weeks, . . .
Early liver transplantation in active drinkers with and without alcoholic hepatitis: a monocentric case series
Authors: Debora Angrisani, Adelaide Panariello, Chiara Mazzarelli, Paola Prandoni, Raffaella Viganò, Marcello Vangeli, Rosa Stigliano, Stella De Nicola, Giovanni Perricone, Aldo Airoldi, Mauro Percudani, Luca Saverio Belli
Journal: Journal of Hepatology (2020)
Semen Analysis
Authors: Rune Eliasson
Journal: Environmental Health Perspectives (1978)

In view of the well known sensitivity of the seminiferous epithelium to various stress factors and to chemicals one would expect that semen analyses would be part of many screening programs to detect dangerous chemicals and environmental hazards. This is not the case, and our knowledge about the production and functional properties of human spermatozoa is mainly based on analyses of specimens from men with barren marriages. A more common use of semen analyses should enable us to better define the normal limits for many of the potentially relevant variables. Due consideration must, however, also be given the time for spermatogenesis and for transit through the epididymis as well as the influence of seminal plasma factors on many functional properties of the spermatozoa. From the scanty information available one can already now presume that careful analyses of motility and morphology of the spermatozoa under standardized conditions will be of help in the early detection of environmental hazards. A more common use of methods for the assessment of such functional properties of the spermatozoa as structural stability, membrane permeability, metabolism, and resistance to physical stress will give additional information about the effects of chemicals and other factors. To exploit these potential methods for the early detection of environmental hazards there is, however, also a need of a changed attitude towards semen analysis from the medical profession as well as from the public.
Non-Union of Fractures
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archives of Environmental Health, Chicago
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cirrhosis and muscle cramps: Evidence of a causal relationship
Authors: P Angeli
Journal: Hepatology (1996)

The aim of the study was to define the features, prevalence, and pathophysiology of therapy for muscle cramps in cirrhotic patients. The first protocol study included 294 cirrhotic patients and 194 age- and sex-matched controls. Controls were defined as inpatients or outpatients without any clinical and laboratory evidence of liver disease. Features and prevalence of muscle cramps were defined on the basis of a standard questionnaire. As far as the pathophysiological associations of muscle cramps were concerned, the following parameters were evaluated: mean arterial pressure (MAP), nutritional status, liver function tests, plasma volume (PV), plasma renin activity (PRA), and electrolyte, mineral, and acid-base status. The prevalence of cramps was higher in cirrhotic patients than in controls, and it was related to the duration of recognized cirrhosis and to the severity of liver function impairment. At a multiple regression analysis, the presence of ascites, low values of MAP, and high values of PRA were the independent predictive factors for the occurrence of cramps in cirrhosis. In the second protocol study, the effects of a sustained expansion of the effective circulating volume induced by intravenous infusion of human albumin were compared with those of a placebo in 12 cirrhotic patients with more than three cramp crises a week. Compared with the placebo, albumin reduced the cramp frequency (P < .01). In conclusion, an increased prevalence of true muscle cramps occurs in patients with cirrhosis. Our data indicate that the pathophysiological link between cirrhosis and cramps may be represented by the reduction of the effective circulating volume. They also indicate that weekly infusion of human albumin may be an effective treatment for cramps in cirrhosis.
Journal of Pediatric Surgery, Philadelphia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
America Gives a Chance
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyponatraemia in children.
Authors: S. J. Ellis
Journal: BMJ (1992)

On admission hewas semiconscious and scored 9 on the Glasgow coma score.He showed writhing movements of his hands and subsequently had a short tonic-clonic fit.Both his plantar responses were extensor, but the remainder of the physical examination gave normal results.Initial investiga- tions showed a serum sodium concentration of 121 mmol/l, potassium 3 9 mmol/l, and chloride 90 mmol/l with a creatinine concentration of 54 [tmol/l and osmolarity of 254 mmol/l.A com-