tbuckley/cabot-search huggingface dataset:
No Support for Regional Selectivity in Clozapine-Treated Patients: A PET Study With [11C]Raclopride and [11C]FLB 457
Authors: M. Talvik
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: The authors' goal was to test the hypothesis of extrastriatal D2 receptor selectivity as the mechanism of action of clozapine. METHOD: Positron emission tomography (PET) was used to examine extrastriatal as well as striatal dopamine D2 receptor occupancy in four patients treated with clozapine and three patients treated with haloperidol. The reference radioligand [11C]raclopride was used for determination of D2 receptor occupancy in the striatum. The radioligand [11C]FLB 457 was chosen for determination of D2 receptor occupancy in the thalamus, the temporal cortex, and the frontal cortex. RESULTS: In patients treated with haloperidol the D2 receptor occupancy was high in all examined brain regions. In clozapine-treated patients the D2 receptor occupancy was relatively low in both the striatum and the extrastriatal regions. CONCLUSIONS: The results from the present study give no support for the hypothesis of regional selectivity as the mechanism of action for clozapine.
Genotoxic Effects of 2-Acetylaminofluorene on Rat and Human Hepatocytes
Authors: Stephen C. Strom, Randy L. Jirtle, George Michalopoulos
Journal: Environmental Health Perspectives (1983)

Isolated rat and human hepatocytes in primary culture were shown to metabolize AAF to reactive intermediates which damaged hepatocyte DNA. A significant increase in unscheduled DNA synthesis was detectable by autoradiography in rat and human hepatocytes exposed to concentrations of AAF as low as 1 microM. When rat hepatocytes were plated over confluent monolayers of human fibroblasts and exposed to 3H-AAF, significant binding of AAF to the DNA of the fibroblasts as well as the hepatocytes was measured. In other experiments with hepatocyte-fibroblast cocultures, nonradioactive AAF, at concentrations greater than 40 microM, induced a significant increase in the HPRT- mutation frequency in the human fibroblasts. These results demonstrate that hepatocytes can be used to assess genotoxicity of carcinogenic compounds and are useful for interspecies comparisons in chemical carcinogenesis.
Treatment of Obesity in Adults
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Talc granulomas of the skin
Authors: M. J. Tye
Journal: JAMA (1966)

SURGICAL GLOVE TALC can cause granulomas in various intestinal and pelvic organs.<sup>1</sup>In the skin, localized silica granulomas due to the glove talc have been observed in surgical scars<sup>2,3</sup>and as the result of the impregnation of the skin by silicious particles, such as glass or sand, following an injury.<sup>' 5</sup>Extensive talc granulomas of the skin have not been reported, to our knowledge. <h3>Report of a Case</h3> A 45-year-old woman was admitted to the hospital because of the development of increasing numbers of lumps on her shoulders, buttocks, and thighs. These nodules had been developing for the past two years and were at sites where she has had as many as 500 boils over the past eight to ten years. Many of these boils were treated by incision and drainage. The nodules have not appeared on areas of the body where she has not had furuncles. She also
Networks, Local Stations Providing Air Time for Physicians to Report, Advise
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Route of herpesvirus spread traced with aid of DNA-cleaving enzymes
Authors: W. A. Check
Journal: JAMA (1979)

DNA restriction endonucleases, enzymes that cleave DNA at specific sites, have been talked about primarily in connection with recombinant DNA technology. Surprisingly, then, one of their first medical applications is not in the synthesis of insulin or human growth hormone, but as a tool for investigating the epidemiology of herpesvirus outbreaks in hospitals. Restriction endonucleases split DNA at specific nucleotide sequences, yielding each time the same unique set of DNA fragments from a given DNA. If the DNA is radioactively labeled, the fragments may be separated on an agarose slab in an electric field and visualized by exposing the slab to roentgenographic film (figure, next page). Analysis of DNA from more than 80 different strains of herpesvirus in the laboratory of Bernard Roizman, ScD, professor of microbiology at the University of Chicago, has shown that any two epidemiologically distinct strains of herpesvirus can be distinguished by the fragments produced from
Fallacy and hazard. Human chorionic gonadotropin-500-calorie diet and weight reduction
Authors: J. C. Ballin
Journal: JAMA (1974)

MORE than two decades ago, A. T. W. Simeons began using human chorionic gonadotropin (HCG) in the treatment of obesity. Simeons, a British-trained physician practicing in Rome, postulated that HCG injections might lead to better adherence to a calorie-restricted diet, fewer symptoms during the period of food restriction, and more rapid mobilization and loss of what he called "abnormal" fat. He described a slower return to obesity in the posttreatment period. The "Simeons regimen" consists of daily intramuscular injections of 125 international units (IU) of HCG six times a week until a total of 40 injections have been given. The drug regimen is accompanied by a 500-calorie diet given in two daily meals. Daily interviews with the patient are designed to review the program and to encourage progress. The Simeons Clinic in Rome has gained international attention, and the "regimen" is now being used in a rapidly expanding chain of
Further Studies on Binding of Exophthalmos-Producing Substance by Normal Human Serum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: A Novel Fusion Toxin Derived from an EpCAM-Specific Designed Ankyrin Repeat Protein Has Potent Antitumor Activity
Journal: Clinical Cancer Research (2011)

In this article (Clin Cancer Res 2011;17:100–10), which was published in the January 1, 2011 issue of Clinical Cancer Research (1), the name of the first author appeared incorrectly on the online journal. The correct name of the first author is Patricia Martin-Killias. This error has been corrected.
Behandlung der angeborenen und erworbenen Gehirnkrankheiten mit Hilfe des Balkenstiches.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The pruritus of cholestasis
Authors: C. N. Ghent
Journal: Hepatology (1999)

iron overload were present, as opposed to some areas of large liver cell dysplasia and clear cell foci.Small encapsulated clusters of necrotic tumoral hepatocytes were found in the peritoneum.Slides of the ruptured tumor were reviewed, and the diagnosis of a macrotrabecular, well-differentiated HCC (Edmondson grade 2) was confirmed.None of the following attributable risk factors for HCC were found: hepatitis B virus (serum DNA), hepatitis C virus (serum RNA), iron overload, alcohol, tobacco, oral contraceptive pills or drugs, diabetes, or personal or family history of liver or biliary disease.Ectopic liver, often linked to the liver by a stalk, should be differentiated from a pedonculated tumor.In our experience, we found 3 cases of pedonculated HCC out of 67 cases of HCC developed on noncirrhotic liver.According to Arakawa, ectopic liver could be more prone to malignant transformation because of metabolic dysfunction.Although this is a possibility, one must remember that in HCC developed on so-called normal liver (without cirrhosis, chronic active hepatitis, or fibrosis), absence of known risk factors is not a rare event.The presence of foci of large liver cell dysplasia and clear cells, lesions shown to be associated with the occurrence of HCC in cirrhosis, could indicate that this patient, even in the absence of cirrhosis, is more prone to develop an HCC.
Direct regulation of bile secretion by prostaglandins in perfused rat liver
Authors: K Beckh
Journal: Hepatology (1994)

Prostaglandins have been postulated to act as mediators of intercellular communication between liver cell populations in the regulation of liver carbohydrate metabolism. Their role in the regulation of bile secretion is rather unclear. The action of prostaglandins on bile flow and bile acid secretion was studied in the in situ perfused rat liver. Infusion of prostaglandin F2α resulted in reduction of bile flow and bile acid secretion. In addition, portal flow was diminished and glucose output was increased. The parameters were altered in a dose-dependent manner. The effects of
Abstract 3053: Development of novel cell-based bioassays for the development of biologics targeting LAG-3 and PD-1xLAG-3
Authors: Jamison Grailer, Denise Garvin, Jim Hartnett, Frank Fan, Mei Cong, Zhi-jie Jey Cheng
Journal: Cancer Research (2019)

Abstract Programmed cell death protein 1 (PD-1) and Lymphocyte-activation gene 3 (LAG-3) are immune checkpoint receptors that bind to PD-L1/PD-L2 or MHCII, respectively, on antigen presenting cells or tumor cells. PD-1 or LAG-3 activation results in the inhibition of T cell receptor (TCR) signaling and reduced T cell activation. However, co-blockade of PD-1 and LAG-3 leads to a synergistic enhancement in T cell responses, suggesting functionally divergent inhibitory signaling mechanisms between the two receptors. Preclinical studies suggest that blocking LAG-3 re-activates the immune system to kill cancer cells, and co-blockade of both PD-1 and LAG-3 lead to a synergistic increase in tumor control and survival in preclinical models. Current methods for measuring the potency of LAG-3 and PD-1xLAG-3 blocking antibodies measure cytokine production from human PBMCs upon Staphylococcal Enterotoxin B (SEB) superantigen stimulation. These protocols are tedious, highly variable, and require the use of highly toxic superantigen. Herein, we describe the development of reporter-based bioassays for the development of LAG-3 and PD-1xLAG-3 combination-targeted biologics. Engineered T effector cell lines expressing LAG-3 alone or in combination with PD-1 are activated in an antigen-dependent manner by APC cell lines. The assays are specific for LAG-3 or PD-1xLAG-3-targeted biologics and are robust as demonstrated by Design of Experiments analyses. In addition, the assays can be used to measure the relative potencies of test samples compared with reference sample in a detection range of 50% to 200% and show appropriate precision, accuracy and linearity. The assays can detect potency changes for heat-stressed samples, and are tolerant to human serum, demonstrating the potential to be further developed into neutralizing antibody (NAb) assays. Therefore, these bioassays can serve as valuable tools for the development of biologics targeting LAG-3 and PD-1xLAG-3. Citation Format: Jamison Grailer, Denise Garvin, Jim Hartnett, Frank Fan, Mei Cong, Zhi-jie Jey Cheng. Development of novel cell-based bioassays for the development of biologics targeting LAG-3 and PD-1xLAG-3 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3053.
Development of new drug delivery system for protein drugs using silicone (I)
Authors: Masako Kajihara, Toshihiko Sugie, Masayuki Mizuno, Nobuhiko Tamura, Akihiko Sano, Keiji Fujioka, Yasuo Kashiwazaki, Takashi Yamaoka, Shuichi Sugawara, Yosuke Urabe
Journal: Journal of Controlled Release (2000)
Science literacy and the role of the physician
Authors: W. R. Hendee
Journal: JAMA (1988)

BASIC standards for science education in the United States are declining. John Brademas, president of New York University, notes<sup>1</sup>: Our elementary and secondary schools are producing a nation of scientific illiterates. Only one in three adults knows clearly what a molecule is and but one in six understands the meaning of the term DNA. More than half of our high school students take no mathematics or science beyond the tenth grade, and... virtually every state is short of teachers in these fields. At the college level, the situation is little better. The percentage of freshmen interested in science has been sliding for the past decade. Compared with students in 17 other countries, including Poland, Thailand, and Hungary, 10-year-olds in the United States placed in the middle and 14- and 17-year-olds placed in the bottom of their respective groups when tested recently for science achievement.<sup>2</sup>These results reflect major
(4) Telangiectasia macularis perstans
Authors: B.R. Allen
Journal: British Journal of Dermatology (1978)

Journal Article (4) Telangiectasia macularis perstans Get access B.R. Allen B.R. Allen General Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue s16, 1 December 1978, Pages 28–29, https://doi.org/10.1111/j.1365-2133.1978.tb15226.x Published: 01 December 1978
INNV-23. SAFETY AND ADVERSE EVENT PROFILE OF TUMOR TREATING FIELDS IN ELDERLY PATIENTS A POST-MARKET SURVEILLANCE ANALYSIS
Authors: Wenyin Shi, Sied Kebir, Martin Glas
Journal: Neuro-Oncology (2018)

Tumor Treating Fields (TTFields) are an established modality for glioblastoma (GBM) treatment administered through the portable Optune system. The efficacy of Optune in newly diagnosed GBM was previously demonstrated in the EF-14 phase 3 trial (n=695). Optune plus temozolomide significantly improved survival in all patient subgroups compared to temozolomide alone, which included those patients 65 years of age (median OS: 17.1 vs 13.7 months). Here, we report post-marketing surveillance data from elderly patients treated with Optune. A review of adverse events in patients 65 years of age. Post-market surveillance data were analyzed based on the MedDRA body system (system organ class) preferred terms. A total of 8025 patients were treated with Optune (newly diagnosed glioblastoma 46.1%, recurrent glioblastoma 46.2%, other 7.7%). Of those, 2574 patients (32.1%) were 65 years of age at the time of Optune treatment. 46% of these elderly patients reported 1 adverse event. Skin reaction was the most prevalent adverse event and occurred in 28% of patients. Similarly, 47% of patients 18 and <65 years of age (N=5421) experienced at least 1 adverse event and 27% developed skin reaction. The remaining adverse events profile was fairly equally distributed between both age groups. This retrospective analysis demonstrates that Optune is used in patients 65 years of age or older. The adverse event profile in this group of elderly patients is comparable to patients younger than 65 years. The most common adverse event registered was skin reaction, which was also found in the phase 3 EF-11 trial for recurrent GBM and in the EF-14 trial for newly diagnosed GBM patients. In summary, these results underline the safety profile of Optune.
Saphenous vein arteriovenous fistulas. Replacement of factor VIII in hemophiliacs
Authors: C. A. Ries
Journal: JAMA (1973)

Subcutaneous arteriovenous fistulas were successfully constructed, using autologous saphenous vein grafts, in two patients with hemophilia. Neither patient had remaining arm veins suitable for infusions of factor VIII. The fistulas have been functioning well for 10 and 13 months.
Abstract 16691: Arrhythmogenic Right Ventricular Cardiomyopathy: comparison between original (1994) and updated (2010) Task Force Criteria.
Authors: Alessandro Blandino, Cristina Gallo, Matteo Anselmino, Carla Giustetto, Elena Richiardi, Elisabetta Toso, Salvatore Miceli, Lucia Garberoglio, Mara Morello, Fiorenzo Gaita
Journal: Circulation (2010)

Introduction: ARVC diagnosis has been based, up to now, on the 1994 international Task Force Criteria (TFC). Due to the high specificity and low sensitivity of this diagnostic approach, a recent in...
Still's disease.
Journal: BMJ (1968)

PointersHypnosis for Asthma: In 'two groups of patients those treated by hypnosis were significantly improved compared with those treated by special breathing exercises (p.71); Leader at p. 67.Spinal Osteoporosis: Higher incidence in white women than in two groups of Bantu.Mechanical stress and muscular activity during earlier life was far greater in the Bantu women.Severe aortic calcification seen in the white women only (p.76).Tetraplegia: Care in highly specialized unit improves prognosis especially in early stages.In late phases social factors become paramount and patients who can be transferred for care in their own homes do better (p.79).Severe Anaemia in Pregnancy: Transfusion of packed blood cells with added ethacrynic acid proved satisfactory in treating 30 Nigerian women who were grossly anaemic (p.84).Carcinoma of the Thyroid: High values of thyrocalcitonin found in patients with medullary carcinoma with amyloid stroma (p.87) ; Leader at p. 67. Rapid Diagnosis of Herpes: Immunofluorescentantibody technique is a reliable diagnostic test for Herpesvirus hominis infections (p.89).Haemoglobin Stanleyville: A fourth subject showing this haemoglobin variant discovered in the Congo Republic (p.92).New Anthelmintic: Tetramisole, a synthetic preparation, cured 94 out of 100 children with ascariasis compared with 85 out of 100 treated with piperazine.There were no side-effects (p.93).Mucosa of the Small Intestine: Scanning elec- tron microscopy is a useful method for studying the mucosa (p.95).Case Reports: Primary peritoneal pregnancy (p.96) ; Iliacus haematoma syndrome after anticoagulants (p.97).Psychiatry: Problems of the first general-practi- tioner consultation (p.99).Today's Drugs: Folic acid and iron (p.102).
Xenon ventilation-perfusion lung scans
Authors: J. A. Martyn
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In their article "Xenon Ventilation-Perfusion Lung Scans: The Early Diagnosis of Inhalation Injury," Schall et al (240:2441, 1978) suggest that the "widespread application of this test will reduce the mortality associated with severe thermal burns." Their study has shown that ventilation-perfusion lung scan is a sensitive test in detecting inhalation injury early in its course. If bronchoscopy is considered the diagnostic standard, the lung scan was abnormal in 21 of 21 patients with abnormal bronchoscopic results. However, if the authors recommend using the ventilation-perfusion scan as a screening test for inhalation injury in most major thermal burn patients, I cannot agree. By the authors' admission, the benefits of using methylprednisolone early in inhalation injury are unproved. Assuming that all patients with major burns are monitored closely for respiratory problems from thermal injury, how would early detection by screening alter the care of these patients, and would early