tbuckley/cabot-search huggingface dataset:
Reply
Authors: Hitendra Garg, Shiv Kumar Sarin, Manoj Kumar, Vishal Garg, Barjesh Chander Sharma, Ashish Kumar
Journal: Hepatology (2011)

We read with interest the letter by Dr. Lo where he raised concerns about placebo treatment for patients with acute exacerbation of chronic hepatitis B. We appreciate his concerns. However, we would like to clarify that Dr. Lo has probably not considered the widely accepted definition of acute-on-chronic liver failure (ACLF)1 and has misunderstood it as merely acute exacerbation of chronic hepatitis B. ACLF is very different from the commonly encountered acute reactivation of chronic hepatitis B. The patients are very sick and the 3-month mortality is >76%, especially when the Model for End-Stage Liver Disease score is >20.2 In contrast of ACLF, the acute reactivation of hepatitis B has a low mortality rate of ∼6%.3 Lamivudine may be helpful in acute reactivation of hepatitis B as it may prevent decompensation. Therefore, the guidelines from Asian Pacific Association for the Study of the Liver and the American Association for the Study of Liver Diseases had recommended antiviral for acute reactivation of hepatitis B.4, 5 When this reactivation has led to decompensation presenting as ACLF, the patients become very sick and require liver transplantation. Use of antiviral treatment for these sick patients was not clear, until conceptualization of our study. There were four published studies prior to 2007 on decompensated severe acute reactivation of hepatitis B, which did not show any definite advantage of antiviral treatment in these patients6-9 (Table 1). Only Chien et al. could show survival benefit in a subgroup of patients on lamivudine who had bilirubin levels <342 μmol/L (20 mg/dL). Keeping in mind the limited benefits attained with lamivudine in previous trials and in our own earlier study,10 in the present study, we assessed the efficacy of a potent antiviral such as tenofovir against placebo. We wish to dispel any misconception in the minds of readers such as Dr. Lo about the ethical approach on which this study was based. We do believe that this well-designed and ethically conducted randomized clinical trial has made seminal observations which would serve as benchmark for clinical practice and help design future antiviral strategies for patients presenting with ACLF due to hepatitis B virus reactivation. Hitendra Garg M.D.* , Shiv Kumar Sarin M.D.* , Manoj Kumar M.D. , Vishal Garg M.D.*, Barjesh Chander Sharma M.D.*, Ashish Kumar M.D.* , * Department of Gastroenterology, G.B. Pant Hospital, New Delhi, India, Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India, Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
Resolution of liver biopsy alterations in three siblings with bile acid treatment of an inborn error of bile acid metabolism (Δ4-3-oxosteroid 5β-reductase deficiency)
Authors: C Daugherty
Journal: Hepatology (1993)

Identical male twins and their brother, cholestatic from birth, with Δ4-3-oxosteroid 5δ-reductase deficiency, were studied by serial liver biopsy. Spectrometry documented defective primary bile acid synthesis and markedly increased levels of atypical oxo and allo bile acids in urine and serum. Hepatocellular cholestásis and giant-cell transformation resolved in parallel with clinical and biochemical recovery during oral bile acid administration. In the twins, portal fibrosis stabilized at a mild level; they are well as 5-yr-olds at this writing. Follow-up biopsy in their brother at 8 mo was normal, and he is doing well at 3 yr of age. Hepatic ultrastructural alterations in all three were characterized by abnormalities of bile canaliculi including small bile plugs, diverticulae and latticelike elaborations of hepatocellular membranes adjacent to bile canaliculi that were shown to have resolved completely on subsequent biopsies. Eight additional cases have been detected on urine screening; only two of these patients have survived, on bile acid therapy. Early diagnosis and treatment improves the prognosis of this otherwise lethal inborn error of bile acid synthesis. (HEPATOLOGY 1993; 18:1096-1101).
Error in Figure
Authors: Robert Tufts, Keerthi Gogineni, Katherine Shuman, Nicole Gabler, Ezekiel Emanuel
Journal: JAMA Oncology (2015)

Roberto Salgado, MD, PhD; Carsten Denkert, MD, PhD; Christine Campbell, MSc; Peter Savas, MD; Paolo Nuciforo, MD; Claudia Aura, MD; Evandro de Azambuja, MD, PhD; Holger Eidtmann, MD; Catherine E. Ellis, PhD; José Baselga, MD; Martine J. Piccart-Gebhart, MD, PhD; Stefan Michiels, PhD; Ian Bradbury, PhD; Christos Sotiriou, MD, PhD; Sherene Loi, MD, PhD
Journal National Cancer Institute, Washington
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Informed Consent
Authors: Hyun G Goh, Sang W Shin
Journal: New England Journal of Medicine (2017)

In their review article (March 2 issue), 1 Grady and colleagues suggest that technological advances could help to facilitate obtaining informed consent without an in-person meeting between participants and investigators.However, we believe that true informed consent needs to go beyond symbolic measures such as clicking blocks electronically or supplying a signature.Without an in-person meeting, participants may feel coerced into participating without the researcher being aware of it.In addition to securing the privacy and confidentiality of participants, mutual trust and confidence must be built while sharing the emotions regarding fear and anxiety about uncertainty and unpredictability of the trial outcome. 2,3 We believe that in-person discussion is an imperative step in obtaining informed consent in most clinical trials.
Rickets. A Study of Economic Conditions and Their Effects on the Health of the Nation, in Two Parts Combined in One Volume.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of genetic variants on liver disease regression in HCV patients with advanced chronic liver disease who achieved SVR to IFN-free therapies
Authors: Bernhard Scheiner, Georg Semmler, Teresa Binter, Karin Kozbial, Philipp Schwabl, David Chromy, David JM Bauer, Benedikt Simbrunner, Theresa Bucsics, Albert Stättermayer, Matthias Pinter, Petra Munda, Michael Trauner, Peter Ferenci, Thomas Reiberger, Mattias Mandorfer
Journal: Journal of Hepatology (2020)
PRIMARY POLYCYTHEMIA
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Threatened Bans on Human Cloning Research Could Hamper Advances
Authors: Joan Stephenson
Journal: JAMA (1997)

A DEMURE-looking Finn Dorset sheep named Dolly—the first mammal to be cloned from a single adult cell—has touched off both a frenzy of media-spun Frankensteinian scenarios involving cloned human beings and a rush by politicians to propose bans on human cloning research. News of the accomplishment, recently described by Ian Wilmut, PhD, Keith H.S. Campbell, DPhil, and colleagues at the Roslin Institute and PPL Therapeutics, near Edinburgh, Scotland, (<i>Nature</i>1997;385:810-813), has, predictably, ignited a vigorous debate about the ethics of cloning human beings that recalls previous controversies surrounding such issues as human embryo research, and in vitro fertilization and other reproductive technologies. The level of anxiety and concern prompted by the new reports is nowhere more apparent than in the rush by various public officials around the globe to propose legislation to outlaw cloning human beings at the very least and in some cases impose what many scientists consider overly
Griseofulvin-phenobarbital interaction in man
Authors: S. Riegelman
Journal: JAMA (1970)

The concept that phenobarbital sodium interferes with metabolism of griseofulvin due to its ability to induce liver enzymes that increase drug metabolism was tested by a random crossover study of six healthy male volunteers who received griseofulvin orally and intravenously, both with and without phenobarbital. The elimination kinetics of griseofulvin for a given subject were identical with or without the administration of phenobarbital; thus, no evidence for enzyme induction was observed. However, the amount of orally administered griseofulvin absorbed with phenobarbital administration fell well below that seen when no phenobarbital was given, implying that phenobarbital reduces absorption of the drug.
Acute myocardial ischemia and alternative diagnoses in low-risk patients for coronary event presenting to the emergency department Alberto Conti, Barbara Paladini, Maurizio Zanobetti, Stefano Grifoni, Stefania Sartini, Sabrina Masetti, Chiara Gallini, Paolo Ferri, Egidio Costanzo, Maria Matteini, Giacomo Trallori. AZIENDA OSPEDALIERA CAREGGI, FIRENZE, Italy
Journal: Journal of the American College of Cardiology (2001)
We Must Find the Answers
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A GREAT WORK ON YELLOW FEVER.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular characterization of β‐thalassemia genes in an Argentine population
Authors: Ariel Roldán, Marina Gutiérrez, Ana Cygler, Mariana Bonduel, Gabriela Sciuccati, Aurora Feliu Torres
Journal: American Journal of Hematology (1997)

This study was designed to identity the β-thalassemia mutations in an Argentine population. Seventy-one pediatric patients and 101 available relatives were studied (85 chromosomes). Diagnosis of β-thalassemia was made by conventional hematological procedures. Molecular studies were carried out by dot-blot and restriction endonuclease analysis on amplified DNA to detect the eight most frequent mutations in the Mediterranean area. We were able to identify 95.3% of the β-thalassemia mutations in the subjects under study. The four common defects (C-39, 47%; IVS-I nt 110, 22.4%; IVS-I nt 1, 9.4%; and IVS-I nt 6, 5.9%) account for 84.7% of the β-thalassemia alleles. The alleles and their distributions showed a close similarity to the spectrum of alleles in Italy. The differences might represent the influence of other immigrations, especially from Spain. We conclude that β-thalassemia in Argentina originated mainly from Italian immigrants. This study will enable us to design an adequate approach to genetic counseling and/or prenatal diagnosis for couples at risk. Am. J. Hematol. 54:179–182, 1997 © 1997 Wiley-Liss, Inc.
MEDICAL HELP FOR INDIA
Journal: JAMA (1953)

During the recent convention of the American Medical Association the Board of Trustees endorsed a joint project of CARE and the World Health Organization to provide needed equipment and supplies to India and neighboring countries. The Trustees' action was followed by one by the Woman's Auxiliary, which adopted a resolution that also pointed up the need for such improved medical services. The project offered by CARE and the World Health Organization is based on a recent WHO survey that established that in India alone there are some 80 hospitals, medical schools, nursing schools, and similar institutions, and 210 more in neighboring countries, with a total of some 42,000 beds, which are in urgent need of the most basic supplies, including bed linen; surgical instruments; simple laboratory equipment; and textbooks on materia medica, pathology, latest surgical and treatment techniques, and similar subjects. A hospital for patients with tuberculosis in Ceylon, for
Plus Not Minus
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Frequent expression of MUC1 apomucin on biliary epithelial cells of damaged small bile ducts in primary biliary cirrhosis and chronic viral hepatitis: An immunohistochemical study
Authors: M Sasaki, Y Nakanuma
Journal: Hepatology (1996)

MUC1 apomucin is a specific target tumor antigen recognized by cytotoxic T cells in a major histocompatibility complex (MHC) unrestricted fashion in patients with pancreatic and breast cancer. This T–cell–mediated immune mechanism against MUC1 apomucin expressing cells has not been evaluated in nonneoplastic immune–mediated diseases. Therefore, we immunohistochemically surveyed the expression of MUC1 apomucin on biliary epithelial cells of small bile ducts in various hepatobiliary diseases, including primary biliary cirrhosis (PBC). MUC1 apomucin was detected using the monoclonal antibody DF3 and the streptavidin–biotin complex, in livers from 31 patients with PBC, 67 with chronic viral hepatitis (CH) with or without cirrhosis, 31 with extrahepatic biliary obstruction (EBO), 30 with hepatolithiasis, and from 23 normal individuals. MUC1 apomucin was infrequently and focally expressed in the biliary epithelial cells of the small bile ducts in 3 of 23 normal livers. In contrast, MUC1 apomucin was frequently and strongly expressed on the luminal surface of biliary epithelia] cells of small bile duct, in 22 of 31 patients with PBC, and in 50 of 67 patients with CH. In particular, high levels of MUC1 apomucin were expressed in bile ducts showing chronic nonsuppurative destructive cholangitis (CNSDC) in PBC and hepatitic duct injuries in CH. In EBO and hepatolithiasis, MUC1 apomucin was focally and weakly expressed in 29% and 30% of livers examined, respectively. More MUC1 apomucin was expressed in PBC and CH than in EBO, hepatolithiasis, and normal liver ( P &lt; .01, respectively). Frequent and high luminal expression of MUC1 apomucin on biliary epithelial cells in damaged small bile ducts in PBC and CH may be related to T–cell–mediated immunologic mechanisms in these diseases, probably by an MHC–unrestricted recognition process.
CLINICAL TETANY BY FORCED RESPIRATION
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Ectopic pregnancies--United States, 1970-1980
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal