tbuckley/cabot-search huggingface dataset:
Investigation of the Central Nervous System. Part I. Methods and Instruments.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOUTHERN SURGICAL AND GYNECOLOGICAL ASSOCIATION.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3817: Improved T cell activation bioassays to facilitate the development of bispecific antibodies and engineered T cell immunotherapies
Authors: Pete Stecha, Denise Garvin, Jim Hartnett, Gopal B. Krishnan, Frank Fan, Mei Cong, Zhi-jie Jey Cheng
Journal: Cancer Research (2018)

Abstract T cells play a critical role in cell-mediated immunity and can mediate long-term, antigen-specific, effector and memory responses. A variety of immunotherapy strategies have been developed recently that are aimed at inducing, strengthening or engineering T cell responses. These have emerged as promising approaches for the treatment of diseases such as cancer and autoimmunity. Current methods used to measure TCR-mediated T cell proliferation and cytokine production rely on primary PBMCs as a source of T cells, which must be stimulated via co-culture with APCs or anti-TCR/CD3 antibodies. These assays are laborious and highly variable due to their reliance on donor primary cells, complex assay protocols and unqualified assay reagents. As a result, these assays are difficult to establish in quality-controlled drug development settings. To overcome this barrier, we developed two reporter-based bioluminescent T cell activation bioassays that can be used for the development of bispecific antibodies and engineered T cell immunotherapies. The assays consist of Jurkat T cells genetically engineered to express luciferase downstream of either NFAT or IL-2 response elements. The T cell activation bioassays reflect the mechanisms of action of biologics designed to induce TCR and/or CD28-mediated T cell activation, as demonstrated using anti-CD3 and/or anti-CD28 antibodies as well as blinatumomab, a bispecific antibody that simultaneously binds CD3 expressed on T cells and CD19 expressed on malignant B cells. The bioassays are pre-qualified according to ICH guidelines and demonstrate assay specificity, precision, accuracy and linearity required for routine use in potency and stability studies. Finally, our data illustrate the use of reporter-based T cell activation bioassays for characterizing and measuring the activity of engineered chimeric antigen receptor T cells. Citation Format: Pete Stecha, Denise Garvin, Jim Hartnett, Gopal B. Krishnan, Frank Fan, Mei Cong, Zhi-jie Jey Cheng. Improved T cell activation bioassays to facilitate the development of bispecific antibodies and engineered T cell immunotherapies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3817.
Editorial Board
Authors: Sian Lewis, Patrick Wilken, Katja Brose, Lewis Packwood, Lara Crow, Mat Mccutcheon, Philip Patenall, Neill Sharp, Anders Björklund, Sweden Lund, Sarah Paul Bolam, Barry Dickson, John Disterhoft, Chris Doe, John Flanagan, Craig Garner, Yukiko Goda, Meyer London, Robert Malenka, Mark Stanford, Richard Mattson, Venkatesh Morris, Maiken Murthy, Nancy Rothwell, Mike Shadlen, Marc Tessier-Lavigne, Chris Walsh, Laura Elias, Arnold Kriegstein, Hirokazu Fukui, Carlos Moraes, Jean-Marc Fritschy, Robert Harvey, Günter Schwarz, W Caudle, Rebecca Colebrooke, Piers Emson, Gary Miller, Susan Masino, Jonathan Geiger, Norman Saunders, C Ek, Mark Habgood, Katarzyna Dziegielewska, Karel Talavera, Bernd Nilius, Thomas Voets, Daniel Johnston, Rishikesh Narayanan, Erik Zornik, Ayako Yamaguchi, William Cafferty, Aaron Mcgee, Stephen Strittmatter, Samuel David, Elizabeth Fry, Rubèn López-Vales, John Mattick, Mark Mehler, John Lisman, Joseph Coyle, Robert Green, Daniel Javitt, Francine Benes, Stephan Heckers, Anthony Grace
Journal: Trends in Neurosciences (2008)
Cardiac arrhythmias and sodium diphenylhydantoin--an appraisal
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obituary Listing
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nuclear War
Authors: MICHAEL E. MURRAY
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 March 1983Nuclear WarMICHAEL E. MURRAY, M.D.MICHAEL E. MURRAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-411_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The letters on the threat of nuclear war published in the December 1982 issue (1-5) tended to reinforce the naivety of the article (6) to which they referred. It is not possible to make valid statements about armament and disarmament without discussing such concepts as first-strike capability and limited nuclear war. These issues are no longer merely theoretical. A numerical listing of the nuclear capability of one or both sides is totally irrelevant in view of the newer problems that have been raised by the very definite possibility that one nation could destroy another's retaliatory capacity without...References1. LEAFHALSTED AT. The threat of nuclear war [Letter]. Ann Intern Med. 1982;97:927. LinkGoogle Scholar2. ORIENT J. The threat of nuclear war [Letter]. Ann Intern Med. 1982;97:927. LinkGoogle Scholar3. SODERSTROM R. The threat of nuclear war [Letter]. Ann Intern Med. 1982;97:928. MedlineGoogle Scholar4. MELLER G. The threat of nuclear war [Letter]. Ann Intern Med. 1982;97:928. MedlineGoogle Scholar5. MENNINGER K. The threat of nuclear war [Letter]. Ann Intern Med. 1982;97:928. MedlineGoogle Scholar6. CASSELJAMETON CA. Medical responsibility and thermonuclear war. Ann Intern Med. 1982;97:426-32. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL E. MURRAY, M.D.Affiliations: Weber Medical Clinic, Ltd. Olney, IL 62450 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1983Volume 98, Issue 3Page: 411-412 ePublished: 1 December 2008 Issue Published: 1 March 1983 PDF downloadLoading ...
Infertility
Authors: Alvin F. Goldfarb
Journal: JAMA (1978)

This new book on infertility describes the author's personal philosophy in the management of this increasingly frequent clinical complaint of married couples. His philosophy and writings are based on 25 years of clinical experience from which he has developed a holistic approach, which he believes to be "the very essence of the managment of the 'infertile couple.' " If the reader is looking for a comprehensive treatise on this subject, he will not find it in this book, whose purpose, rather, is to guide the clinician in the management of infertility problems. There are 29 chapters, each rather short, and more than 100 charts and illustrations. The excellent tables compare the author's results with those of other investigators, thus allowing the reader to draw his own conclusions concerning the efficacy of various treatment programs. The book is divided into six sections, including historical perspectives, causes, workup, management, and therapy. A special
PUERPERAL ARTHRITIS.
Authors: EDWARD E. MORSE
Journal: JAMA (1905)

The following case of puerperal sepsis is presented for consideration: <h3>History.</h3> —Mrs. X., aged 20, primipara, with a history of gonorrhea a few months earlier, was delivered on June 9, no unusual features characterizing the labor. On the third day following delivery she complained of a chill and the temperature was found to be 101 F. With a slight morning remission, the temperature continued to rise until 105 F. was recorded on the third day. I first say the case at this time. <h3>Course of the Disease.</h3> —For five weeks the temperature ranged between subnormal and 105, on July 20 becoming normal and so remaining for five days. At no time during the illness was there evidence of much pain or tenderness about the uterus and appendages, the predominant and alarming feature being a profound exhaustion. On July 25, the patient complained of tenderness in the left shoulder and elbow;
Phase I trial of oral etoposide in combination with celecoxib in patients with advanced malignancies
Authors: T. H. Luu, P. Twardowski, L. Leong, D. Lim, R. Morgan, M. McNamara, J. Portnow, C. Ruel, S. Shibata, T. Synold, J. Doroshow
Journal: Journal of Clinical Oncology (2005)

3201 Background: Preclinical studies demonstrate antiangiogenic activity with low doses of etoposide. Selective cyclooxygenase-2 inhibitors are also potent inhibitors of angiogenesis. The objective of this trial was to describe the toxicities of the combination of low dose etoposide with escalating doses of celecoxib in patients with advanced malignancies. Methods: Patients were treated with a fixed dose of oral etoposide at 50 mg daily. There were four dose levels of celecoxib: 100 mg/200 mg/300 mg/400 mg twice daily. Four weeks of therapy constituted one cycle. The celecoxib dose level of 400 mg twice daily was expanded to allow the initiation of a companion biological correlative study to assess changes in the levels of circulating endothelial cells and endothelial cell precursors in patients during therapy. Results: Fifty six patients (28 F;28 M) were entered. Median age was 59 (23–81).The most common tumor types included: lung (11), ovary (7), colon (5), breast (4), adenocarcinoma of unknown primary (4), prostate (3). The majority of patients were heavily pre-treated with standard chemotherapy regimens. Drug-related grade 3 and 4 toxicities included neutropenia (8), anemia (5), fatigue (3), mucositis (3), nausea (2), GI bleed (1), thrombosis (1), and hypertension (1). No patients died from adverse effects related to drug toxicity. No responses were noted. Twenty four patients had stable disease for at least 8 weeks. The longest duration on therapy was 318 days in a patient with metastatic thyroid cancer. Conclusions: The combination of oral etoposide at 50 mg daily and celecoxib 400 mg twice daily is well tolerated. Most toxicities appear to be related to cytotoxic effects of etoposide. No excessive thrombotic, hemorrhagic or cardiovascular complications related to celecoxib were observed. Further study of this regimen is warranted, but potential clinical benefit is unlikely to be reflected by traditional tumor response criteria. Supported by NCI CA62505 No significant financial relationships to disclose.
Worse Cardiovascular Outcomes Found in Disadvantaged Areas
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary veno-occlusive disease. Morphological changes suggesting a viral cause
Authors: P. J. McDonnell
Journal: JAMA (1981)

A 47-year-old man with a history of industrial exposure and interstitial lung disease was admitted for acute pulmonary decompensation. Clinical course was characterized by severe dyspnea at rest, fever, hypoxemia, and elevated pulmonary arterial pressures. At autopsy, pulmonary problems were explained by a selective veno-occlusive process. Associated with pulmonary phlebitis was cerebral vasculitis and lymph node enlargement with erythrophagocytosis suggesting underlying viral infection. Pulmonary veno-occlusive disease should be considered in cases of pulmonary fibrosis, pulmonary hypertension with cor pulmonale, and pulmonary edema and congestion with normal left atrial pressures. (<i>JAMA</i>1981;246:667-671)
银屑病患者关节炎发展的标志物 CXCL10 水平随时间的推移而下降
Journal: British Journal of Dermatology (2020)

这项在加拿大进行的研究旨在检查 CXCL10 的下降是否是 PsA 患者特有的，该研究在多次就诊中监测其水平。这是通过测量在同一时间段内出现了 PsA 和没有出现 PsA 的银屑病患者血液中 CXCL10 的水平来完成的，还使用了统计模型进行了分析。
SUSCEPTIBILITY OF THE ENDOCARDIUM TO INFECTIOUS PROCESSES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stroke Rehabilitation
Authors: Sheldon Berrol
Journal: JAMA (1986)

This book presents a truly multidisciplinary perspective on stroke management. Most appreciated is the consideration of early intervention and surgical perspectives, themes that are frequently overlooked in rehabilitation texts. Although some issues are addressed by several authors, the individual approaches to problems, such as rehabilitation surgery, provide the reader with a more comprehensive view than one would get otherwise. Biomechanical issues are therefore presented from the viewpoint of the physiatrist, the orthopedist, and the rehabilitation therapist. Two authors legitimize Gerstmann's syndrome in their discussion; one would hope that the concept that these symptoms make up a valid syndrome would by this time have been omitted from current literature. Otherwise, the discussions on the various stroke syndromes constitute a good review, which is enhanced by the chapter on the relationship of the motor and sensory systems to cortical and subcortical structures. Radiological diagnostic procedures have substantially increased our ability to diagnose
Boxing-Reply
Authors: Ronald J. Ross
Journal: JAMA (1983)

<h3>In Reply.—</h3> Regarding Mr Naviaux's comments, we have consulted our statistician, who states the following: "A multiple regression analysis is inappropriate given the nature of this data. CT scan results are not a continuous variable, and assumptions of the normality of the residual error will not hold, rendering<i>P</i>values from this type of analysis meaningless. Although other analysis indicates a significant age effect, there is still a significant effect between the number of bouts and CT score." Even after age adjustments, one can conclude that the more bouts fought by boxers, the greater the risk of an abnormal CT scan, but especially in boxers aged 50 years or older (Figure). Mr Naviaux points out an interesting possibility, however, which, as far as we know, has not been adequately studied and should be. He poses the following question: could the normal CT scan changes that occur with age be accelerated
American Society of Nephrology, 25th annual meeting. Baltimore, Maryland, November 15-18, 1992. Abstracts.
Journal: Journal of the American Society of Nephrology (1992)

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Mitral valve repair for patients with pure mitral insufficiency. 1- to 15-year follow-up
Authors: J. H. Kay
Journal: JAMA (1976)

Mitral valve repair rather than replacement was performed in 133 of 183 patients (73%) with considerable mitral valve insufficiency requiring surgery. There were seven operative deaths (5%) and 16 late deaths in the 133 patients followed up from 1 to 15 years. Only four of the late deaths were possibly related to the underlying valvular heart disease. Repair is preferable to replacement with present-day mitral valve prostheses. (<i>JAMA</i>236:1584-1586, 1976)
Genetic Cell Repository: A Major Resource—and Still Growing
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal