tbuckley/cabot-search huggingface dataset:
Identification of Needs in Biomarker Research
Authors: Jonathan B. Ward, Rogene E. Henderson
Journal: Environmental Health Perspectives (1996)

Interest in the use of biological markers to evaluate future disease risk has increased greatly in recent years.Biomarkers are observable end points in a continuum of events leading from expo- sure to toxic agents to diseases that ultimately result from exposure.Because many significant diseases develop over long periods of time, methods for detecting early events that can predict risk are important for disease prevention.Biomarkers are generally categorized as detecting expo- sure, effects of exposure, or individual susceptibility to exposure.Although there has been significant progress in the technical development of biomarkers, implementation of their use in human populations has progressed much more slowly.We discuss four major needs in the development of biomarkers.First, new biomarkers need to be developed to fill gaps in our ability to observe steps in the continuum from exposure to disease.Second, the relationships between biomarker responses and disease pathology needs to be better understood.Third, the sensitivity, specificity, and variability of biomarkers need to be better characterized and they must be better validated as predictors of disease risk.Fourth, there are several societal impediments to the practical implementation of biomarker studies as public health tools.A common agreement among employers, employees, regulators, and the legal community must be established regarding appropriate and ethical uses and interpretation of biomarker data.
Epidemiology and Toxicology of Arsenic Poisoning in Domestic Animals
Authors: Lloyd A. Selby, Arthur A. Case, Gary D. Osweiler, Howard M. Hayes
Journal: Environmental Health Perspectives (1977)

Arsenic poisoning is one of the more important causes of heavy metal poisoning in domestic animals. Two species--dogs and cattle--are intoxicated more frequently than other animals; yet sporadic instances of poisoning have been observed in cats, horses, and pigs. Cases observed by veterinary clinicians are either peracute, acute, or chronic intoxications. Frequently the initial and only indication that a severe problem exists with peracute poisoning in a cattle herd is dead animals. Chronic intoxications are also observed in cattle. Acute intoxication is the most common form of arsenic poisoning observed and documented in the dog. Also intoxicated dogs were younger, i.e., 2-6 months of age. Arsenic is a severe alimentary tract irritant in domestic animals, and treatment in most instances consists mainly of symptomatic and supportive treatment. The source of intoxication, when it can be determined, is usually dips, sprays, powders, or vegetation contaminated by pesticides containing arsenic.
NATHAN STRAUS' WORK IN CHICAGO.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eleventh Annual Symposium of the Lineberger Cancer Research Center
Journal: JNCI Journal of the National Cancer Institute (1987)

Eleventh Annual Symposium of the Lineberger Cancer Research Center Get access JNCI: Journal of the National Cancer Institute, Volume 78, Issue 2, February 1987, Page 397, https://doi.org/10.1093/jnci/78.2.397-b Published: 01 February 1987
Diagnostic and therapeutic technology assessment. Vasoactive intracavernous pharmacotherapy for impotence: papaverine and phentolamine
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Authors: Byung-Cheol Song, Yoo-Kyung Cho, Hyeyoung Jwa, Eun Kwang Choi, Heung Up Kim, Hyun Joo Song, Soo-Young Na, Sun-Jin Boo, Seung Uk Jeong
Journal: Clinical and Molecular Hepatology (2015)

5IU/mL".
ITALY
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLINICAL OBSERVATIONS AND MECHANICAL REFINEMENT.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pertussis—United States, 1997-2000
Journal: JAMA (2002)

Pertussis was a major cause of morbidity and mortality among infants and children in the United States during the prevaccine era (i.e., before the mid-1940s). Following the introduction and widespread use of whole-cell pertussis vaccine combined with diphtheria and tetanus toxoids (DTP) among infants and children in the late 1940s, the incidence of reported pertussis declined to a historic low of 1,010 cases in 1976 (Figure 1). However, since the early 1980s, reported pertussis incidence has increased cyclically with peaks occurring every 3-4 years. In 1996, less reactogenic acellular pertussis vaccines (DTaP) were licensed and recommended for routine use among infants. This report summarizes national surveillance data for pertussis during 1997-2000 and assesses the effectiveness of pertussis vaccination in the United States during this period. The findings indicate that pertussis incidence continues to increase in infants too young to receive 3 doses of pertussis-containing vaccine and in adolescents and adults. Prevention efforts should be directed at maintaining high vaccination rates and managing pertussis cases and outbreaks.
Detection of serum hepatitis C virus RNA in HCV antibody-seropositive volunteer blood donors
Authors: P McGuinness
Journal: Hepatology (1993)

Approximately 90% of subjects with chronic hepatitis resulting from hepatitis C virus infection have hepatitis C virus RNA in serum. However, the prevalence of hepatitis C virus RNA in serum from subjects with hepatitis C virus antibody associated with persistent normal liver biochemical values is unclear. Do these subjects have resolved or continuing infection with hepatitis C virus? The aim of this study was to examine whether subjects with hepatitis C virus antibody but normal ALT levels had evidence of ongoing infection. Our study population was divided into four groups. Groups 1, 2 and 3 comprised hepatitis C virus antibody-positive volunteer blood donors. Group 1 was made up of subjects found to be hepatitis C virus antibody-positive on enzyme-linked immunosorbent assay with persistent abnormal ALT levels (59 donors: 53 positive on recombinant immunoblot assay and 6 indeterminate). Group 2 members were hepatitis C virus antibody positive, with persistent normal ALT levels (50 donors: 39 positive on recombinant immunoblot assay and 11 indeterminate). Group 3 members were hepatitis C virus seropositive but negative on second-generation recombinant immunoblot assay (n = 48). Twenty patients (not blood donors) with chronic liver disease who were anti-hepatitis C virus seronegative were used as controls (group 4). Serum samples from all four groups were assayed for hepatitis C virus RNA on reverse transcription and a 40-cycle polymerase chain reaction with a combination of primers from the highly conserved 5′-noncoding and less-conserved third and fourth nonstructural regions. All assays were confirmed on hybridization with an internal probe. In group 1,55 of 59 subjects (93.2%) had hepatitis C virus RNA in serum. In group 2, 21 of 50 subjects (42%) had hepatitis C virus RNA in serum. Twenty-one of the 39 recombinant immunoblot assay-positive subjects (53.9%) had hepatitis C virus RNA, compared with none of the 11 recombinant immunoblot assay-indeterminant subjects (p = 0.001 on x2 assay). In recombinant immunoblot assay-positive subjects with normal ALT readings less than 1 mo apart, 7 of 8 (87.5%) had RNA in serum, compared with 14 of 31 patients (45%) who were followed for at least 1 mo (mean, 6.1 ± 6.7) (p = 0.03 on X2 assay). No subject in group 3 or in group 4 had hepatitis C virus RNA in serum. In conclusion, approximately 40% to 50% of subjects with hepatitis C virus antibody positivity and persistent normal liver biochemical values have continuing hepatitis C virus infection. (HEPATOLOGY 1993;18:485–490.)
HOSPITAL DEADBEATS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Age Factors Potentiating Drug Toxicity in the Reproductive Axis
Authors: Richard F. Walker
Journal: Environmental Health Perspectives (1986)

Traditionally, drug toxicity in the reproductive system has been a concern only as it affects fertility and fecundity in young individuals. The purpose of this report is to address the potential problem of synergy between drug actions and abnormal secretion of reproductive hormones that together produce disease in older individuals. Thus, reproductive toxicity has different, but no less serious implications in aging individuals. During aging, the coordinated function of elements within the reproductive neuroendocrine axis degrades. This change promotes atypical secretion of hormones producing abnormal responses in target organs and thus creates a condition with pathogenic potential. Certain drugs may contribute to reproductive toxicity in aging individuals either by accelerating the process of dysregulation and/or by synergizing with hormones to stimulate pathologic changes in target tissues. The geriatric population of the world is increasing, and since it consumes a proportionately larger percentage of drugs than younger groups, this novel form of reproductive toxicity may represent a problem in drug safety that warrants serious consideration.
Further Ethics Resources
Authors: Kaspar A. Zurcher
Journal: Annals of Internal Medicine (1995)

Letters1 April 1995Further Ethics ResourcesKaspar A. ZurcherKaspar A. ZurcherSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-7-199504010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent annotated bibliography, Dunn and colleagues [1] failed to address one important ethical relationship among physician, patient, and society: the environmental issue. This issue is of increasing significance for several aspects of the medical profession, including 1) the obligation to reinforce arguments for an ecologically oriented policy in the interest of our patients and their health [for example, air pollution]; 2) pressure against environmental contamination by the medical industry or by medical treatment [for example, prohibition of inhalation devices containing halogenated hydrocarbon propellents that destroy the stratospheric ozone layer]; and 3) attention to our personal ...REFERENCE1. Dunn PM, Gallagher TH, Hodges MO, Prendergast TJ, Rubenfeld GD, Tolle SW, et al. Medical ethics: an annotated bibliography. Ann Intern Med. 1994; 121:627-32. Google Scholar Author, Article, and Disclosure InformationAuthors: Kaspar A. Zurcher PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1995Volume 122, Issue 7Page: 557KeywordsAir pollutionBehaviorEnvironmental healthFoodForecastingHydrocarbonsInhalationMotivationPollutionTemperature ePublished: 15 August 2000 Issue Published: 1 April 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Incorrect Terminology, Spelling
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIETY NEWS.
Authors: Landon B. Edwards
Journal: JAMA (1895)

<h3>Southwestern Iowa Medical Association.</h3> —The semi-annual meeting of the Southwestern Iowa Medical Association was held in Red Oak, Iowa, August 15. Attendance sixty.— The physicians of Douglas County, Kansas, met at Lawrence, Kan., August 10, and formed a society. The following officers were elected: President, W. S. Bunn; Vice President, J. I. Douthart; Secretary, H. Ernest. <h3>Mississippi Valley Medical Association.</h3> —The secretary of this Association desires to announce that the railroad rates for the Detroit meeting September 3, 4, 5 and 6 will be one and one-third regular fare, on the certificate plan. In purchasing ticket to Detroit full fare will be paid. On request, the local ticket agent will furnish purchaser with certificate which will be handed to the secretary at Detroit. This certificate when signed and vised by the agent of the Central Traffic Association will entitle holder to a return ticket at one-third regular fare.Frederick C.
Staphylococcal food poisoning associated with an Easter egg hunt
Authors: G. A. Merrill
Journal: JAMA (1984)

Staphylococcal contamination of intact, hard-boiled eggs resulted in the food poisoning of an estimated 300 children out of 850 who had participated in an Easter egg hunt. Enterotoxigenic staphylococci that were isolated from the Easter eggs matched that obtained from an infected cook who prepared the eggs three to five days before the hunt and which he left unrefrigerated. Experimental studies demonstrated that heated eggs can absorb 2 mL of contaminated cool water through intact eggshells. When water was inoculated with pathogenic staphylococci at even low contamination levels, rapid growth and enterotoxin production within cooked eggs could be easily duplicated. This is the first large outbreak of its type; safeguards can and should be employed to prevent future ones. (<i>JAMA</i>1984;252:1019-1022)
Lateral whiplash
Authors: D. R. Rudy
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I have read with pleasure the story of Castleton Medical College (<b>204</b>:698,1968). As you probably know the medical college at Woodstock, Vt, like that at Castleton, contributed much to the life of Vermont and New England. The memory of these institutions ought to be kept alive. These two medical colleges sent comparatively well-trained physicians out into the state to care, as best they could, for the people. I sometimes wonder whether one can say as much for most of our modern American medical schools! I hope that a goodly number of people will be stimulated by your article to contribute money to save the chapel.
Author's Name Misspelled
Authors: Scot Silverstein
Journal: JAMA (1999)

eral sectors is downright illegal, and university employees fall under Department of Labor workplace standards and laws for their respective states.Universities have serious ethical and credibility problems if they have such poor control over their employees that they cannot promise to protect individuals from actions contrary to their own grievance policies and that are probably illegal.Favoritism toward senior faculty (eg, in the form of a university "blind eye" to abuses) is probably a major factor in many of the problems surrounding authorship.In a sense, it sends the message that "crime pays."I am also concerned that legal issues of intellectual property were not discussed.The meaning of authorship in the academic sense seems quite different from authorship in the legal sense.Universities are not above the law.They are subject to US and international laws on intellectual property, such as copyright and patent law.These laws make it clear that only tangible, written work is copyrightable and that the person who creates the tangible expression "owns" the work (holds the copyright) unless work-for-hire or other legal co-owner agreements apply. 2 I suggest that one way to clear up the controversies over intellectual property and accreditation is for universities to bring their policies in line with the law of the land and to enforce such policies firmly, fairly, and uniformly.
MEDICAL NEWS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal