tbuckley/cabot-search huggingface dataset:
LYMPHATICS OF THE SKIN
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal osteodystrophy
Authors: N. Bricker
Journal: JAMA (1970)

Dr. Jerome D. Cohen, Chief Resident in Medicine, the Jewish Hospital of St. Louis, and Instructor in Medicine, Washington University School of Medicine: A 60-year-old white woman was referred to Jewish Hospital in October 1968 for evaluation of renal failure. The patient had been entirely well until 18 months before admission when she first experienced throbbing, bitemporal headaches. The physician found the patient to be hypertensive and she was given a rauwolfia compound. Twelve months prior to hospitalization, anemia was discovered and iron therapy was started although the cause of the anemia was not determined. Six months before hospitalization, the patient complained of back pain unassociated with chills or fever, but accompanied by urinary frequency, dysuria, and nocturia. These symptoms were followed by increasing weakness, fatigue, anorexia, nausea, and vomiting. One month prior to entry the patient was admitted to another hospital for evaluation. At that time the blood pressure
Telemedicine
Authors: R. Kevin Grigsby
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I read with great interest the article by Drs Perednia and Allen.<sup>1</sup>I agree that there are many unresolved issues related to the implementation of telemedicine in the US health care system. However, the authors state, "In almost every telemedicine project, teleconsultation accounts for less than 25% of the use of the system. The majority of on-line time is used for medical education and administration." This is certainly not true for the Medical College of Georgia (MCG). From November 1991 through October 1994, a total of 355 telemedical clinical consultations were completed at the MCG across a wide range of medical specialties. Although physicians requesting consultations with MCG faculty can earn Category I continuing medical education credit by participating in the teleconsultation process, the system is used for actual medical consultation. Continuing education might be described best as "value added." The authors might also wish to
Polyhydramnios in anencephaly
Authors: J. Nichols
Journal: JAMA (1966)

In a newborn infant with esophageal stenosis and atresia extending 9 cm, the amniotic fluid volume was found to be normal, yet this infant could not possibly have swallowed. In a case of anencephaly in which the infant had partial esophageal atresia and stenosis extending 1 cm, the infant swallowed sodium diatrizoate (Hypaque Sodium) injected into the amnion, yet the mother had polyhydramnios. Two more cases of anencephaly are presented in which the infants swallowed radiopaque media, yet both mothers had polyhydramnios. These findings emphasize that polyhydramnios is a complex phenomenon and indicate that "failure to swallow" cannot explain all such cases associated with esophageal atresia and anencephaly.
Arterial calcification simulating aneurysm
Authors: H. C. Redman
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Abdominal aortic aneurysms are often excised following the discovery of a pulsatile abdominal mass associated with the radiographic finding of vascular calcification in the abdomen. This calcification, usually seen to the left of the spine, is often associated with a medial soft-tissue mass. The calcification is assumed to be in an aneurysmally dilated abdominal aorta. The pulsatile mass is considered confirmatory evidence of an abdominal aortic aneurysm. Two cases of superior mesenteric arterial calcification which simulated aortic aneurysm in patients with a pulsatile abdominal mass have been seen recently. These cases are reported to emphasize the importance of preoperative angiography to confirm the actual existence of an aneurysm. <h3>Report of Cases:—</h3> Routine physical examination on a 68-year-old woman with chronic brain syndrome revealed a pulsatile midline abdominal mass without bruit located below the umbilicus. This was felt to represent an aortic aneurysm clinically. Plain films of the
The First Synthetic Estrogen
Authors: John Ashby
Journal: Environmental Health Perspectives (1998)

of data, statistical analysis, etc.However, we now consider that biological factors, of which we are unaware and for which we have not controlled, have the potential to exert developmental effects on testis weight which are at least as great as the maximum effects that can be induced by the addition of a potent estrogen (DES) to the mother's drinking water during pregnancy and lacta- tion.This conclusion, and our other experiences outlined above, have obvious relevance to the ongoing debate regarding the design and application of in vivo tests for the detec- tion of adverse effects ofhormone disruptors.We consider it our scientific responsibility to bring these matters to the attention of all those involved in this area.
Placebo-controlled, double-blind, prospective, randomized study of the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID study group
Authors: R. Arnold, H. Müller, C. Schade-Brittinger, A. Rinke, K. Klose, P. Barth, M. Wied, C. Mayer, B. Aminossadati
Journal: Journal of Clinical Oncology (2009)

4508 Background: Octreotide is currently used for the control of symptoms in patients with gastroenteropancreatic neuroendocrine tumors (NETs). However, the ability of long-acting somatostatin analogues to control the growth of well-differentiated metastatic NETs is a matter of debate. The analysis of the first randomized, double-blind, placebo-controlled, multicenter, phase IIIb study of octreotide LAR in patients with metastatic NETs of the midgut is presented. Methods: Treatment-naïve patients with histologically confirmed locally inoperable or metastasized well-differentiated NETs and a Karnofsky index &gt;60 were randomized to receive either octreotide LAR 30 mg/month (mo) or placebo for 18 mos, or until tumor progression or death. The primary endpoint was median time to tumor progression. Secondary endpoints included objective tumor response rate (WHO criteria), measured every 3 mos, as well as symptom control and overall survival. This was a planned interim analysis using the Lan-DeMets error spending approach. Results: Eighty-five patients (n=43 octreotide LAR; n=42 placebo) have been enrolled to date and data from 67 patients with tumor progressions and 16 deaths (n=7 octreotide LAR; n=9 placebo) are included here. Median time to tumor progression in the octreotide LAR and placebo groups were 14.3 mos and 6 mos, respectively (HR: 0.34; 95% CI: 0.20–0.59; P=0.000072). After 6 mos of treatment, stable disease was seen in 67% and 37.2% of patients treated with octreotide LAR and placebo, respectively. Due to the low number of observed deaths, median survival time could not be estimated. Conclusions: Octreotide LAR significantly lengthens median time to tumor progression compared with placebo in patients with metastatic NETs of the midgut. Patients treated with octreotide LAR had a 66% risk reduction of tumor progression compared with patients receiving placebo. Octreotide LAR demonstrates substantial tumor control and shows a more favorable antiproliferative response than placebo as two-thirds of patients treated with octreotide LAR achieved stable disease at 6 mos. [Table: see text]
Manual of Florida Crippled Children's Commission
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hearing.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Byline
Journal: JAMA Surgery (2019)

Aurélie Birenbaum, MD; David Hajage, MD, PhD; Sabine Roche, MD; Alexandre Ntouba, MD; Mathilde Eurin, MD; Philippe Cuvillon, MD, PhD; Aurélien Rohn, MD; Vincent Compere, MD, PhD; Dan Benhamou, MD; Matthieu Biais, MD, PhD; Remi Menut, MD; Sabiha Benachi, MD; François Lenfant, MD, PhD; Bruno Riou, MD, PhD; for the IRIS Investigators Group
Glucagon effect on intracellular proteolysis and pericanalicular location of hepatocyte lysosomes in isolated perfused guinea pig livers*1
Authors: R LENZEN
Journal: Hepatology (1995)

In guinea pigs, glucagon choleresis is accompanied by a significant, but transient, stimulation of biliary protein secretion, which can be accounted for mainly by biliary discharge of lysosomal enzymes. To clarify whether intracellular proteolysis-a process regulated by glucagon and taking place predominantly in the lysosomes-may interact with biliary protein secretion, we determined hepatic proteolytic activity and bile secretory function during substrate deprivation, amino acid supplementation, and glucagon administration in isolated perfused guinea pig livers. To further elucidate the nature of transient lysosomal enzyme release into bile during glucagon infusion, we analyzed pericanalicular distribution of lysosomes by quantitative electron microscopy. The results demonstrate that intracellular proteolysis is accompanied by biliary excretion of lysosomal enzymes. Glucagon-induced secretion of these enzymes as well as labeled proteins into bile occurs independent of protein breakdown and cannot be modulated by addition of amino acids as potent inhibitors of intracellular proteolysis. During glucagon administration, bile canalicular area and pericanalicular distribution of secondary lysosomes show a rapid increase, which persists during the entire infusion period and thus does not explain the transient biliary release of lysosomal enzymes. We therefore postulate that regulation of this process must be located beyond the lysosomal compartment, either involving transport processes or intracellular kinetics of lysosome formation or altered fusion kinetics at the bile canalicular membrane compartment. Metabolic and biliary effects of glucagon seem to occur independent of each other and to underly different regulatory mechanisms.
ERGOSTEROL, A PRECURSOR OF THE ANTIRACHITIC VITAMIN
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome of primary tumor in patients with synchronous stage IV colorectal cancer receiving combination chemotherapy without surgery as initial treatment
Authors: G. A. Poultsides, E. L. Servais, L. B. Saltz, S. Patil, N. E. Kemeny, J. G. Guillem, M. Weiser, L. K. Temple, W. Wong, P. B. Paty
Journal: Journal of Clinical Oncology (2009)

CRA4030 Background: In the absence of symptoms (bleeding, perforation, obstruction) or resectable metastatic disease, primary tumor resection in patients who present with synchronous metastatic colorectal cancer (CRC) is of uncertain benefit. The purpose of this study was to describe the frequency of intervention necessary to palliate the intact primary tumor in patients who present with synchronous stage IV CRC and receive up-front modern combination chemotherapy without prophylactic surgery. Methods: Using a prospective institutional database, we identified 233 consecutive patients from 2000 through 2006 with synchronous metastatic CRC and an unresected primary tumor who received oxaliplatin- or irinotecan-based, triple-drug chemotherapy (FOLFOX, IFL, or FOLFIRI) with or without bevacizumab as their initial treatment. The incidence of subsequent use of surgery, radiotherapy, and/or endoluminal stenting to manage primary tumor complications was recorded. Results: Of 233 patients, 217 (93%) never required surgical palliation of their primary tumor. Sixteen patients (7%) required emergent surgery for primary tumor obstruction or perforation, 10 patients (4%) required nonoperative intervention (stent or radiotherapy), whereas 213 (89%) never required any direct symptomatic management for their intact primary. Of those, 47 (20%) ultimately underwent elective colon resection at the time of metastasectomy and 8 (3%) during laparotomy for hepatic artery infusion pump placement. Neither use of bevacizumab, location of the primary tumor in the rectum, or metastatic disease burden were associated with increased intervention rate. In addition, when included as a time-varying covariate in a Cox regression model, the need for emergent intervention did not correlate with overall survival. Conclusions: Most patients with synchronous stage IV CRC who receive up-front modern combination chemotherapy never require palliative surgery for their intact primary. These data support the use of chemotherapy, without routine prophylactic resection, as the appropriate standard practice for patients with neither obstructed nor hemorrhaging primary colorectal tumors in the setting of metastatic disease. [Table: see text]
Cutaneous myiasis of the eyelid due to Cuterebra larva
Authors: M. S. Cogen
Journal: JAMA (1987)

HUMAN myiasis is the invasion of the body tissues of man by larvae of flies of the order Diptera. The disease occurs worldwide and many species of flies are involved.<sup>1</sup>Occurrence in the United States is infrequent, and human myiasis caused by the highly host-specific botflies is rare.<sup>2</sup>We report a case of dermal botfly myiasis of the eyelid due to a<i>Cuterebra</i>larva, which developed after an apparent insect bite occurring remotely over the ipsilateral clavicle. We emphasize the importance of differentiating this condition from the bacterial furuncle that it closely resembles. <h3>Report of a Case</h3> A 28-year-old man was initially seen with a three-week history of a swollen, tender nodule on his right upper eyelid. The patient, who worked as a lumberjack, had no recent history of travel outside the state of Alabama. The patient stated that two weeks before the onset of symptoms, he was
The conservative treatment of appendiceal peritonitis
Authors: A. Ochsner
Journal: JAMA (1981)

I enjoyed reading Dr Foraker's article, "A Reluctant Surgeon at Sea," inThe Journal(1981;245:2302-2303). Obviously, Dr Foraker is an internist and I want to congratulate him on using excellent judgment in treating the patient with a ruptured appendix. Undoubtedly, he saved the man's life. I don't know whether Dr Foraker is familiar with the conservative treatment of appendiceal peritonitis, first advocated by my distinguished cousin, Dr A. J. Ochsner of Chicago, in the latter part of the last century. Antibiotics were not yet available and infections were controlled only by good surgical treatment and the patient's resistance. Everyone has agreed that acute appendicitis should be operated on as soon as the diagnosis is made, but Dr Ochsner made the important observation that when peritonitis occurred, it frequently took precedence over the acute appendicitis. He believed these cases were better treated conservatively, particularly if there was beginning localization, because of
Current Concepts in Leukemias and Lymphomas Conference
Journal: JNCI Journal of the National Cancer Institute (1984)

Current Concepts in Leukemias and Lymphomas Conference Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 3, March 1984, Page 769, https://doi.org/10.1093/jnci/72.3.769-c Published: 01 March 1984
The limited reliability of physical signs for estimating hemodynamics in chronic heart failure
Authors: L. W. Stevenson
Journal: JAMA (1989)

The cardiovascular physical examination is used commonly as a basis for diagnosis and therapy in chronic heart failure, although the relationship between physical signs, increased ventricular filling pressure, and decreased cardiac output has not been established for this population. We prospectively compared physical signs with hemodynamic measurements in 50 patients with known chronic heart failure (ejection fraction,.18±.06). Rales, edema, and elevated mean jugular venous pressure were absent in 18 of 43 patients with pulmonary capillary wedge pressures greater than or equal to 22 mm Hg, for which the combination of these signs had 58% sensitivity and 100% specificity. Proportional pulse pressure correlated well with cardiac index (<i>r</i>=.82), and when less than 25% pulse pressure had 91% sensitivity and 83% specificity for a cardiac index less than 2.2 L/min/m<sup>2</sup>. In chronic heart failure, reliance on physical signs for elevated ventricular filling pressure might result in inadequate therapy. Conversely, the adequacy of cardiac output is assessed reliably by pulse pressure. Our results facilitate decisions regarding treatment in chronic heart failure. (<i>JAMA</i>1989;261:884-888)
Abstracts
Journal: Clinical Nuclear Medicine (2001)

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