tbuckley/cabot-search huggingface dataset:
SAT0110 Is periodontal disease a risk factor for rheumatoid arthritis? The anti-citrullinated antibody repertoire in periodontal disease
Authors: P. de Pablo, T. Dietrich, I.L. Chapple, M. Milward, M. Chowdhury, P.J. Charles, C.D. Buckley, P.J. Venables
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Studies suggest that periodontal disease may be a risk factor for rheumatoid arthritis (RA). Anti-citrullinated peptide/protein antibodies (ACPA) are highly specific for rheumatoid arthritis and ACPA epitope spreading arises several years prior to onset of clinical features of the disease. <h3>Objectives</h3> To determine the immune reactivity to citrullinated antigens in patients with and without periodontal disease. <h3>Methods</h3> ACPA serology was determined in patients with and without periodontal disease, which was diagnosed by periodontal examination and/or radiographs. In addition to anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV), we tested for antibodies with specificity for different citrullinated peptides, including vimentin (cit-vim), fibrinogen (cit-fib) and their uncitrullinated forms (vim and fib, respectively), as well as the citrullinated α-enolase peptide-1 (CEP-1) and its arginine-containing control peptide (REP-1). Multiple regression models were used to evaluate differences in ACPA response between individuals with and without periodontal disease, adjusting for potential confounders such as age, sex and smoking. <h3>Results</h3> The sample included 96 (49%) patients with periodontal disease and 98 (51%) without periodontal disease, none of whom had rheumatoid arthritis at inclusion. Compared with patients without periodontitis, presence of periodontal disease was associated with higher median levels of the citrullinated peptides CEP-1 (4.45 vs. 6.45; p&lt;0.001) and cit-vim (4.7 vs. 6.5; p&lt;0.001), and their uncitrullinated controls, REP-1 (0.079 vs. 0.154; p&lt;0.001) and vim (2.4 vs. 3.65; p&lt;0.0001), in bivariate analysis. There was no difference between groups in the response against cit-fib; however, antibody levels against fib, its uncitrullinated form, were also higher in patients with periodontitis compared with patients without periodontitis (0.178 vs. 0.104, respectively; p&lt;0.001). After adjusting for age, sex and smoking, patients with periodontitis had 68% (p=0.007), 49% (p=0.04) and 51% (p=0.03) higher anti-CEP-1, anti-REP1 and anti-fib antibody titres, compared with patients without periodontitis. <h3>Conclusions</h3> In patients without rheumatoid arthritis, periodontitis may be associated with higher titres of antibodies to both citrullinated and uncitrullinated peptides. This findings warrant longitudinal studies to define the nature and causality of the association between periodontal disease and rheumatoid arthritis. <h3>Disclosure of Interest</h3> None Declared
CONCERNING THE PARATHYREOID GLANDS (Sandström), OR THE EPITHELIAL BODIES OF THE THYREOID (Kohn).
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Testing Limits
Authors: Elena M. Massarotti, Paul E. Sax, Leigh Compton, Bruce D. Levy, Joseph Loscalzo
Journal: New England Journal of Medicine (2016)

A previously well 57-year-old woman presented to her internist during the summer with a 1-week history of achiness, malaise, anorexia, and fevers. She reported a cough and persistent pain in the right upper quadrant and had no nausea, vomiting, or diarrhea.
Death caused by recreational cocaine use. An update
Authors: R. E. Mittleman
Journal: JAMA (1984)

The epidemiologic, pathological, and toxicological findings of 60 cocaine-related overdose deaths from middle 1978 through 1982 were studied and compared with a previous publication by this office. In addition, 180 deaths where cocaine was an incidental toxicological finding are also discussed. Currently, the average street cocaine fatality victim is 29 years old, and 42% of the victims are female. Blacks comprise 39% of the cases. The blood cocaine concentration in "street cocaine" fatality victims averaged 6.2 mg/L with a wide range, necessitating careful interpretation of the toxicological results in conjunction with terminal events. Although autopsy findings were generally nonspecific, multiple needle-puncture marks with surrounding ecchymoses are typical of IV cocaine abuse. An increase in cocaine-related overdose deaths is anticipated because of its popularity, increasing availability, and, currently, the increased purity of street cocaine. (<i>JAMA</i>1984;252:1889-1893)
Addendum for Euro Surveill. 2018;23(15)
Journal: Eurosurveillance (2018)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Addendum This article is an addendum to the following content: A cluster of two human cases of tick-borne encephalitis (TBE) transmitted by unpasteurised goat milk and cheese in Germany, May 2016
Fluoride Supplements
Authors: Frederick J. Margolis
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Medical professionals have been working for years in an effort to further water fluoridation efforts in this country. Water fluoridation is by far the cheapest and most effective way to give lifetime protection against decayed, missing, and filled teeth and tooth loss. Currently, there is a serious problem at hand because the phosphate fertilizer industry is in financial distress and fluoride as a by-product of the inorganic fertilizer production is in short supply. In fact, several communities have already had to remove fluoride from their water supply. In the event that water fluoridation is discontinued in a local community, there is an effective alternative that is the responsibility of the physician. I refer to the use of fluoride supplements that are necessary during the first eight to ten years of life and will reduce the caries rates just as effectively as water fluoridation. We found in our
Flowcharts in children's notes increase documentation of possible intentional injury
Journal: BMJ (2002)

Some caution is needed in interpreting Cochrane reviewsCochrane reviews contain methodological and other weaknesses, in particular the over-rating by the reviewers in their conclusions of the benefits of new interventions.Olsen and colleagues (p 829) assessed the quality of a sample of 53 reviews first published in the Cochrane Library in 1998 and found major problems in 15.The evidence did not fully support the conclusion in nine reviews, the conduct or reporting was unsatisfactory in 12, and stylistic problems (such as errors in spelling or grammar) occurred in 12.The authors say that although the Cochrane Library remains a key source of evidence on the effects of health interventions, the reviews should be interpreted cautiously.
IgM Gammopathy and the Lupus Anticoagulant Syndrome in Habitual Aborters-Reply
Authors: Norbert Gleicher
Journal: JAMA (1986)

<h3>In Reply.—</h3> We are pleased to respond to the letter by Finazzi et al about our article. We never intended to suggest that an IgM gammopathy needs to occur in every patient with a circulating lupus anticoagulant syndrome and pregnancy loss. Our attention to the phenomenon arose when we noticed an IgM gammopathy in the four sequential patients described in our article. We made the point that the incidence of IgM gammopathy in patients with CLAS still needs to be established. Finazzi et al confirmed our observation by reporting one IgM gammopathy in four patients with this syndrome. Since our original publication we have seen a considerable number of additional patients with CLAS. The presence of an IgM gammopathy was observed in some but not all of these patients. The incidence still needs to be established. Immunoglobulin electrophoresis should represent an integral part of the workup of the patient with
The Dysenteries
Authors: J. S. K. Boyd
Journal: BMJ (1951)

The term " dysentery " is widely and loosely applied to all forms of diarrhoea in which the stools contain mucus and blood.In this article, however, it is proposed to restrict discussion to bacillary and amoebic dysentery, with a brief mention of some other forms of protozoal dysentery.I. BACILLARY DYSENTERY This is an acute infectious disease in which the funda- mental lesion is ulceration of the mucous membrane of the large intestine and the dominant symptom is frequent and painful diarrhoea with stools containing, or consist- ing solely of, blood and mucus.Geographical DiRtribution.-Bacillarydysentery was at one time regarded as a tropical disease but is now known to be widespread throughout temperate climates as well.Nevertheless, the more severe and occasionally fatal cases, particularly those caused by Shiga's bacillus, are in the main confined to tropical and subtropical countries, while the milder forms, especially infections with Sonne's bacillus, are more common in cooler, regions.Aetiology and Morbid Anatomy Bacillary dysentery is caused by infection with organisms of the genus Shigella.The most important of these is the bacillus described by Shiga, Shigella dysenteriae, which produces a potent toxin and gives rise to severe symptoms which may be fatal.BRmisHI
Album
Authors: Stanley Cohen
Journal: Annals of Internal Medicine (2016)

Ad Libitum19 January 2016AlbumStanley Cohen, MDStanley Cohen, MDFrom Atlanta, Georgia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-2108 Audio Reading - “Album” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Album," by S. Cohen. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Do I see my childrenor their photos in my memorythrough unmeasured momentssleeping on the dockwalking home after schoolcaptured on silvered film.I thought he was taller thenthough perhaps I was instead.The fictions are now altereda contrivance for the spiritthat said I would know should know would always rememberconstantly rerecordedwondering what's editedknowing another somethingmust have been erasedfor its replacement Author, Article, and Disclosure InformationAffiliations: From Atlanta, Georgia.Current Author Address: Stanley Cohen, MD, Children's Center for Digestive Health Care, 993D Johnson Ferry Road, #440, Atlanta, GA 30342; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Album” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Album," by S. Cohen. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 19 January 2016Volume 164, Issue 2Page: 119KeywordsChild healthChildrenHealth careMemoryWalking ePublished: 19 January 2016 Issue Published: 19 January 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
In This Issue/Research Watch/News-in-Brief/News from the IASLC Tobacco Control Committee
Journal: Journal of Thoracic Oncology (2016)

This study evaluated the prognostic value of volumetric computed tomography (VolCT) in 129 patients with stages I-IV malignant pleural mesothelioma (MPM) from six North American institutions.There were discordant clinical staging in most cases, confirming the inadequacy of current criteria.VolCT estimates demonstrated a good overall correlation (Spearman correlation 0.822), with several significant discordance.Four common sources of variability were determined by root cause analysis of the largest discrepancy: data entry error, perception error, user error, and error secondary to limited distinction between tumor and adjacent tissues.Median tumor estimates were comparable within subgroups of cases representing each pathological T descriptor and increased monotonically for each reference pathologist with increasing pathological T status.In summary, the findings suggest good correlation between VolCT estimates in most cases reviewed by two independent radiologists, and qualitative association of VolCT with pathological T status.The sources of user error identified would guide design of a follow-up study to investigate interobserver variability of VolCT and its impact on clinical MPM staging.(p.1335) Value of the Glasgow Prognostic Score as a Prognostic Factor in Resectable NoneSmall Cell Lung CancerThe authors conducted a retrospective study on the association of the Glasgow prognostic score (GPS), which is based on the serum C-reactive protein (CRP) and albumin levels, with prognosis of 1,048 patients with operable stage I or II Nonesmall cell lung cancer (NSCLC).Patients categorized as GPS-0, -1, and -2 showed a 5-year overall survival (OS) rates of 91.2%, 78.3%, and 75.8%, respectively.Significant differences in OS were observed between GPS-0 and -1 (p < 0.001), and GPS-0 and -2 (p < 0.001).Multivariate analysis demonstrated significant association between OS and variables such as male (p ¼ 0.031), vascular invasion (p < 0.001), lymph node metastasis (p < 0.001), and GPS (p ¼ 0.025).Taken together, the data indicates a significant association between a high GPS and poor OS, demonstrating the prognostic value of this inflammation-based score in patients with resectable NSCLC.(p.1311)
Milton's Blindness
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P03.07 The prognostic value of a novel quantitative MGMT promoter methylation score for patients with glioblastoma
Authors: S. Han, A. Ravi
Journal: Neuro-Oncology (2017)

Evidence continues to solidify the central role molecular markers play in gliomas. Methylation status of MGMT promoter has been shown as a key marker in glioblastoma, predicting response to temozolomide. Traditional testing of MGMT promoter methylation, performed using a methylation specific PCR, yields a binary result; however it fails to consider the multiple potential methylation sites in MGMT’s promoter region. A novel quantitative bisulfite Sanger DNA sequencing assay evaluates methylation status at each of the 17 potential methylation sites in the promoter, resulting in a methylation score of 0–17. This novel assay was evaluated for its prognostic role in a cohort of 180 consecutive patients undergoing treatment for newly diagnosed glioblastoma at UCSF from April 2014 to August 2015. All patients received concurrent chemoradiation with temozolomide. Univariate and multivariate models for overall survival were built along with other established prognostic variables such as age, KPS and extent of resection. The methylation score was predictive of overall survival as a linear model. Stratification into partition groups revealed 3 groups with the best prognostic group consistent of patients younger than 70, KPS greater than 70, and MGMT score higher than 8. Brier score revealed lower predictive error for the methylation score compared to the traditional binary MGMT promoter methylation assessment, suggesting the methylation score is a more reliable model predicting survival. The methylation score, derived from the bisulfite sequencing analysis, provides a quantitative representation of the degree of methylation in the MGMT promoter. Survival models and partitioning support its role as a prognostic marker for overall survival, and the methylation score being superior to the traditional MGMT promoter methylation analysis in predicting survival in patients with newly diagnosed glioblastoma. Prospective validation and comparison to older/newer techniques including next-generation sequencing are warranted.
HCV core protein subcellular localization: Analysis by confocal and electron microscopy and correlation with the cell cycle . *Liver cancer and molecular virology, Inserm U370, Paris, France. IDepartment of Virology II. National Institute of Health, Tokyo, Japan. $Laboratoire de Biologie et Ultrastructure du Noyau, CNRS UPR 272, Villejuif, France
Journal: Hepatology (1995)
Conjunctivitis Due to Chlamydophila felis (Chlamydia psittaci Feline Pneumonitis Agent) Acquired From a Cat: Case Report with Molecular Characterization of Isolates from the Patient and Cat
Authors: J HARTLEY, S STEVENSON, A ROBINSON, J LITTLEWOOD, C CARDER, J CARTLEDGE, C CLARK, G RIDGWAY
Journal: Journal of Infection (2001)
BTS Guidelines for the Management of Chronic Obstructive Pulmonary Disease
Journal: Thorax (1997)

These guidelines have been replaced by British Guideline on the Management of Asthma. A national clinical guideline . Superseded By 2012 Revision Of 2008 Guideline: British Guideline on the Management of Asthma. Thorax 2008 May; 63(Suppl 4): 1–121.
Evidence of dietary copper and zinc deficiencies
Authors: L. M. Klevay
Journal: JAMA (1979)

The mean daily amounts of copper and zinc found in hospital diets by atomic absorption spectrometry were 0.76 and 9.4 mg, respectively. Comparison of these diets with published data showed median daily amounts of copper and zinc to be 0.78 and 12.0 mg, respectively, for 20 diets made from conventional foods. These amounts of copper and zinc are less than the 2 mg of copper and 13 mg of zinc thought to be required daily by adults. Hospital diets and perhaps diets in general seem to be low in copper and zinc; the amounts of copper are lower than those of zinc in comparison with respective requirements. Common dietary amounts of these elements may cause health problems. (<i>JAMA</i>241:1916-1918, 1979)
Personal View
Authors: J. Older
Journal: BMJ (1985)

An alcoholic woman who was admitted to hospital for detoxification was prescribed thyroxine because of hypothyroidism and mianserin to alleviate severe depression. After several weeks9 treatment she became unwell and was readmitted to hospital. Haematological examination indicated agranulocytosis. Further extensive investigations elicited no cause for this other than the mianserin, since no such disturbance has been reported for thyroxine after years of use. Thus mianserin is probably implicated in this case of agranulocytosis. Although the response may have been idiosyncratic, it highlights the need to monitor new drugs during the early phases of widespread use.
Aminophylli Oral vs rectal administration
Authors: J. P. Lillehei
Journal: JAMA (1968)

The widespread preference for rectal rather than oral administration of aminophylline was questioned and comparisons were made in 13 adults. Throughout four hours of testing, mean theophylline concentrations in the blood were higher with oral administration after fasting than with rectal administration by suppository or retention enema. In every patient, oral administration gave the highest blood theophylline concentration. After 500 mg of aminophylline in uncoated tablets was taken orally, a so-called therapeutic blood concentration developed in every patient.
Clinical Report.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How to Take Notes on Lectures
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal