tbuckley/cabot-search huggingface dataset:
Difficulties in obtaining kidneys from potential postmortem donors
Authors: S. N. Chatterjee
Journal: JAMA (1975)

Disease outcome and kidney disposition of 86 patients referred as potential postmortem kidney donors were followed up over a one-year period to determine factors that led to "organ wastage." Six patients died before fulfilling the electroencephalographic criteria for death; another six were referred too late, leaving insufficient time to contact the relatives; and in 16 patients, permission was refused by the next of kin. In eight cases, no relatives could be traced and, finally, 14 patients died without fulfilling our criteria of acceptability. Organs were obtained from only 22 donors—25.5% of the total referrals. Any data presenting the number of potential postmortem kidney donors must be considered in the light of factors incorporating the ease or difficulty with which kidney grafts can be obtained. An awareness of these factors is necessary for maximum utilization of potential kidney donors. (<i>JAMA</i>232:822-824, 1975)
Efficacy of pegylated liposomal doxorubicin (PLD) and oxaliplatin (Ox) in pre-treated advanced epithelial ovarian cancer (EOC) in relation to BRCA status
Authors: M. O. Nicoletto, M. E. Donach, L. Borgato, G. Artioli, S. Zovato, C. Barile, R. Bertorelle, G. Cartei
Journal: Journal of Clinical Oncology (2007)

16006 Background: The mechanism of action of PLD+Ox suggests that and carriers of BRCA mutations might have better survival compared to sporadic ovarian cancer even when pre-treated in advanced EOC. Methods: Inclusion criteria: Performance Status&lt;=2, relapse or progression after 1–3 lines of therapy; &lt;=4 prior antiblastic drugs; life expectancy &gt;3 months; LVEF &gt;50%, informed consent. Treatment consisted of 1 hr infusion of PLD 30–35 mg/m 2 on day 1 and 70 mg/m 2 of Ox in 2 hrs on day 2 for 8 cycles, then 2 cycles of PLD alone. Clinical response was evaluated by CT scan every 3 cycles. Primary endpoints were overall survival and its correlation with BRCA mutations and p53. Results: From June 2000, 63 pre-treated pts with advanced EOC were enrolled. Median age = 62 yrs, range 41–83, (18pts &gt;70 yrs). 17 had known germline BRCA1/2 mutations (10pts) or family history of ovarian cancer (4pts). In this BRCA/high-risk population 15 pts were evaluable for response with ORR=93.3% (8 CR, 6 PR&gt;50%, 1 SD). 139 courses were administered (median = 10 courses/pt). There was 1 episode of G3 toxicity: mucositis; G1–2 toxicity was gastrointestinal (16 episodes), mucositis (11 episodes), neutropenia (9 episodes). Median LVEF showed no significant changes during treatment. There is no clear correlation between OS and amount of Platinum/Taxol administered previously. p53 was analyzed for expression and mutations. Mutations were sought in exons 5, 6, 7 and 8. 5/6 CR evaluable for p53 showed overexpression. p53 overexpression was seen in 9/11 evaluable pts; of these 4/9 also had p53 mutations. 3/4 of these patients obtained a complete response. Median survival from 1 st cycle has not been reached; mean survival is 63.6 months vs 24.7 for sporadic EOC (p&lt;.001). Presently 15/17 are alive. The 5-yr survival after first course of therapy is estimated at 82%. BRCA/high-risk patients in PLD-Ox therapy also fared better than counterparts from an historical population (OS from diagnosis 179.4 vs 141.1 months, p=.005). Conclusions: PLD+Ox is well tolerated and highly effective in BRCA/high-risk patients and in p53 positive/mutated pts in this population. This therapy offers low toxicity providing good quality of life. No significant financial relationships to disclose.
Erratum
Journal: BMJ (1888)

cuted paper models of cattle.horses, deer, rabbits, etc., which the b)oy had made.-ProfessorIIAMILTON had observed that the brain was the most highly convoluted one he hadll ever met withlalmost applroaching tlhat of the cetacean.Cas.e of so-called ,SpontaneotA (CSnbus.tion.--Dr.MAC.K.:,ZI.: BooTI (described a ncase which lie had iiet with.It will lhe -l)llllished in full in the .JOUINtAL.E;RRATrlt.-Iulthe report of the !)ro'ee(Illg's f thez sliliurhlatvidllll Nol' tlh )llrhlanl Melital So(iety.i)thl!IshIPl Iil thle JL'I
Acute Renal Failure
Authors: Naveen Singri, Shubhada N Ahya, Murray L Levin
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Issue Highlights
Journal: Circulation (2005)

There currently is great interest in understanding the role of certain chronic infections as risk factors for cardiovascular disease.In this regard, prior studies have suggested that chronic periodontal disease is associated with increased cardiovascular risk, although it remains possible that the confounding effects of smoking and other classical risk factors explain the association.In this issue of Circulation, Beck and colleagues investigated the relation between periodontal disease and prevalent coronary heart disease in 5002 participants in the fourth examination of the Atherosclerosis Risk in Communities Study.They observed that elevated serum IgG antibodies to several oral pathogens were associated with coronary heart disease, but findings on oral examination were not.Although further prospective studies of this question are needed, the present study suggests that the host response to oral infection may be more important for cardiovascular risk than the local extent of periodontal disease.See p 19.
Is the Oregon rationing plan fair?
Authors: N. Daniels
Journal: JAMA (1991)

THE OREGON Basic Health Services Act mandates universal access to basic care, but includes rationing services to those individuals who are Medicaid recipients. If no new resources are added, the plan may make current Medicaid recipients worse off, but still reduce inequality between the poor and the rest of society. If resources are expanded and benefits given appropriate rankings, no one may be worse off; though inequality will be reduced, alternative reforms might reduce it even further. Whether the outcome seems fair then depends on how much priority to the well-being of the poor we believe justice requires; it also depends on political judgments about the feasibility of alternative strategies for achieving more egalitarian reforms. Oregon makes rationing public and explicit, as justice requires, but it is not clear how community values influence the ranking of services; ultimately, the rationing process is fair only if we may rely on the
BOOK REVIEWS
Authors: D. E. HENSON
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article BOOK REVIEWS Get access Advances in Cancer Control: Screening and Prevention Research-Progress in Clinical and Biological Research, Volume 339 . Paul F. Enstrom , Barbara Rime , Lee E. Mortenson , eds. New York : Willey-Liss , 1990 , 495 pp. $105. DONALD EARL HENSON DONALD EARL HENSON Early Detection Branch, Division of Cancer Prevention and Control, National Cancer InstituteBethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 6, 20 March 1991, Pages 443–444, https://doi.org/10.1093/jnci/83.6.443-a Published: 20 March 1991
CERVICAL RIBS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
Authors: Omkar U. Kawalekar, Roddy S. O’ Connor, Joseph A. Fraietta, Lili Guo, Shannon E. McGettigan, Avery D. Posey, Prachi R. Patel, Sonia Guedan, John Scholler, Brian Keith, Nathaniel W. Snyder, Ian A. Blair, Michael C. Milone, Carl H. June
Journal: Immunity (2016)
Tobacco Use Among High School Students— United States, 1990
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PATHOLOGICAL INSTITUTE OF THE NEW YORK HOSPITALS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COPD guidelines
Authors: A. WHITTLE, M G PEARSON
Journal: Thorax (1999)

The case history is described of a young woman who presented with primary pulmonary hypertension and non-specific inflammatory signs.The patient received prolonged immunosuppressive treatment with low dose methotrexate and prednisone without any vasodilator agent.After one year the pulmonary artery pressure fell from a mean value of 47 mm Hg to 30 mm Hg and there was a corresponding clinical response.This case suggests that, in patients with pulmonary hypertension of unknown origin, immunopathogenetic factors should be sought in order to consider the utility of immunosuppressive therapy.
Gametocytemia in falciparum malaria. Eradication of gametocytemia with primaquine
Authors: S. J. Berman
Journal: JAMA (1971)

<i>Following successful treatment of a patient with falciparum malaria which was acquired in Vietnam, persistent gametocytemia was noted. Since recent studies suggest such gametocytes remain infective for the</i>Anopheles<i>vector, undetected gametocytemia could lead to the reintroduction of falciparum malaria in this country. Treatment with primaquine phosphate will eradicate</i>Plasmodium falciparum<i>gametocytes, and is recommended for prevention of transmission of falciparum malaria</i>.
Insulin and Proinsulin: Relations and Implications
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Flutamide versus Orchidectomy in the Treatment of Metastatic Prostate Carcinoma
Authors: L. Boccon-Gibod, G. Fournier, P. Bottet, J.M. Marechal, J. Guiter, P. Rischman, J. Hubert, J.Y. Soret, P. Mangin, C. Mallo, C. Esctein Fraysse
Journal: European Urology (1997)
GRAPHOLOGY.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Standard nomenclature for primary hepatic tumors. A critical need
Authors: E. T. Mays
Journal: JAMA (1976)

THE TERMINOLOGY for tumors composed of hepatocytes is superfluous. It is permeated with synonyms. Archaic nomenclature mattered little in the past. Benign primary tumors of the liver were rare. Etiology was unknown. They usually occurred in the extremes of life; in the very young, they were considered congenital, and they corresponded to known potentials for tumorigenesis in the elderly. Malignant primary tumors were also rare in the United States and usually occurred in the chemically or alcoholically damaged liver. Little did it matter if these growths were called hepatoma, hamartoma, liver-cell adenoma, benign hepatoma, solitary adenoma, or hepatic adenoma. Nor did it matter if vague histologic criteria separated these growths from a group of tumor-like lesions again described by various synonyms, including focal nodular hyperplasia, focal cirrhosis, hamartomatous cholangiohepatoma, isolated nodules of regenerative hyperplasia, mixed adenoma, adenoma, and solitary hyperplastic nodule. But now nomenclature does matter. A medley of jolting
Bladder Preservation in Selected Patients with Muscle-Invasive Bladder Cancer by Complete Transurethral Resection of the Bladder Plus Systemic Chemotherapy: Long-Term Follow-up of a Phase 2 Nonrandomized Comparative Trial with Radical Cystectomy
Authors: Eduardo Solsona, Miguel A. Climent, Inmaculada Iborra, Argimiro Collado, José Rubio, José V. Ricós, Juan Casanova, Ana Calatrava, Jose L. Monrós
Journal: European Urology (2008)
Public Health Consequences of Acute Displacement of Iraqi Citizens—March-May 1991
Journal: JAMA (1991)

In late March 1991, following military and civil strife in Iraq, approximately 400,000 ethnic Kurds and other Iraqi minority groups sought refuge in rugged mountains on the border of Iraq and Turkey; an additional estimated 1.3 million Iraqi refugees fled to Iran. In contrast to groups affected in other recent refugee emergencies, a large proportion of this displaced population comprised educated urban dwellers. This report describes the major public health consequences of this population displacement and international relief efforts directed toward these problems.
Financial insolvency as a risk factor for mortality among patients with cancer.
Authors: Aasthaa Bansal, Scott David Ramsey, Catherine R. Fedorenko, David K Blough, Karen A Overstreet, Veena Shankaran, Polly A. Newcomb
Journal: Journal of Clinical Oncology (2015)

6509 Background: Patients with cancer are more likely to file for bankruptcy than the general population, but the impact of severe financial distress on health outcomes among cancer patients is not known. Methods: We linked Surveillance, Epidemiology and End Results (SEER) cancer registry records and federal bankruptcy records for Western Washington and identified patients who were diagnosed with cancer from 1995 to 2009. We used propensity score matching to account for differences between patients who filed for bankruptcy and those who did not, with respect to age, gender, race, marital status, residence type, income, stage at diagnosis, and treatment(s) received. In the propensity score matched sample, we used Cox proportional hazards models to compare overall survival between patients who filed and those who did not. Results: Compared to patients who did not file for bankruptcy (n = 226,868), those who filed (n = 4,728) were more likely to be younger, female, non-white, have local or regional (vs. distant) stage disease at diagnosis and have received treatment. After propensity score matching, 7,682 patients remained in the analysis, 3,841 subjects in each group. Both groups had a mean age of 53 (SD 14.7), more men than women (54%), a mean income of $49,000 (SD $12,000), and majorities of white (86%), married (60%) and urban (91%) patients. Most patients in both groups were diagnosed with local or regional stage cancer (84%) and both groups received similar first courses of treatment. Compared to cancer patients who did not file for bankruptcy, the adjusted hazard rate for mortality among patients who filed was 75% higher [HR 1.75, 95% CI (1.61, 1.91)]. Excess mortality risk following bankruptcy varied by cancer type, with colorectal, prostate, lung and thyroid cancers having the highest risk. Excluding patients who were distant stage at cancer diagnosis from the analysis had little impact on the mortality risk. Conclusions: Severe financial distress requiring bankruptcy protection following cancer diagnosis appears to be a risk factor for mortality. Further research is needed to understand the process by which extreme financial distress influences survival after cancer diagnosis, and to find factors that could mitigate this risk.
SPOROTRICHOSIS
Authors: RICHARD L. SUTTON
Journal: JAMA (1910)

Since the publication of Schenck's<sup>1</sup>article, in 1898, less than a dozen instances of sporotrichal infection in man have been reported from America. France has furnished a vast majority of the cases up to the present, a fact which probably is due as much to the interest that the affection has aroused among French medical men (and the consequent recognition of the disease when encountered) as to any excessive prevalence of the disorder in that particular part of the world. <h3>CASE REPORTS IN THE LITERATURE</h3><h3>Case 1.—</h3> Schenck's patient (whose case was the first in which the infecting agent was isolated and provisionally classified) was a male laborer, aged 36 years. The course of the disease was typical. Three months previous to the date of examination, the patient had sustained a slight scratch wound (from an iron nail) on the dorsal surface of
Drowning or Thirsting: The Extremes of Availability of Medical Information
Journal: PLoS Medicine (2006)

The March 2006 issue of PLoS Medicine contains the following editorial and a thoughtful debate on the issue of direct-to-consumer advertising of prescription drugs. The same issue contains a fascinating article on a "low tech" approach to information management, the blue trunk approach. This electronic journal is one of several published by the non-profit Public Library of Science (PLoS), a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. PLoS Medicine is an open-access, on-line journal that contains timely discussions and new findings on a broad range of medically-related topics. Readers are referred to the PLoS Medicine website: http://www/plosmedicne.org to read the full pro and con debate mentioned in this paper and to learn more about this valuable intellectual resource.