tbuckley/cabot-search huggingface dataset:
Physicians with Georgia on their minds
Authors: M. F. Goldsmith
Journal: JAMA (1989)

INTERNAL UNREST may require the expertise of physicians other than gastroenterologists these days. Numerous countries are experiencing varied forms of political upheaval, some of which lead to injury and/or death among the population and subsequent medical investigation. Three American physicians who visited Soviet Georgia in midMay following nationalist demonstrations in Tbilisi, the capital city, have now recounted their experience. The American physicians who went to Georgia are Barry H. Rumack, MD, director of the Rocky Mountain Poison Center and professor of toxicology and of pediatrics at the University of Colorado Medical Center in Denver; Jennifer Leaning, MD, chief of emergency services at Harvard Community Health Plan and attending physician at Harvard Medical School's Brigham and Women's Hospital, Boston; and Ruth A. Barron, MD, assisting attending psychiatrist at McLean Hospital and a Harvard Medical School faculty member. At the request of Soviet physicist Andrei Sakharov and the invitation of health authorities
HEALTH CARE - ASSOCIATED INFECTIVE ENDOCARDITIS. AN UNDESIRABLE EFFECT OF HEALTH CARE UNIVERSALIZATION
Authors: J.M. Lomas, F.J. Martínez-Marcos, A. Plata, R. Ivanova, J. Gálvez, J. Ruiz, J.M. Reguera, M. Noureddine, J. de la Torre, A. de Alarcón
Journal: Clinical Microbiology and Infection (2009)
ANNUAL REPORT ON GRADUATE MEDICAL EDUCATION IN THE UNITED STATES
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In this issue
Authors: Peter Kirkpatrick Senior, Alexandra Flemming, Charlotte Harrison, Sarah Crunkhorn, Monica Hoyos, Man Tse, Mariam Faruqi, Susanne Harris, Catriona Rodwell Editorial Assistants, Emily Finn, Rebecca Cromie, Judith Shadwell, Simon Fenwick, Patrick Morgan, Vicky Summersby, Natalie Smith
Journal: Nature Reviews Drug Discovery (2014)
Placental Transfer of Cadmium in Rats: Influence of Dose and Gestational Age
Authors: B. R. Sonawane, M. Nordberg, G. F. Nordberg, G. W. Lucier
Journal: Environmental Health Perspectives (1975)

Placental transfer rates of cadmium were investigated in rats in relation to dose (0.1, 0.4, and 1.6 mg Cd/kg) and the gestational age (12, 15, and 20 days) when rats were treated. Pregnant rats were injected intravenously with a single dose of 109CdCl2 (approximately 20 muCi/animal), and animals were sacrificed after 24 hr. 109Cd concentrations were measured in the fetus, placenta, maternal liver, and blood. Cadmium crossed the placenta at all doses and at all gestational ages tested. However, higher percentages of administered cadmium accumulated in the fetus with increasing dose and increasing gestational age. For example, after pregnant rats were injected with low, middle, and high doses of Cd on day 12 of gestation, fetuses accumulated 0.0001, 0.0028, and 0.0095 per cent of the injected dose, respectively. Percentages of administered Cd detected in placental tissue did not change consistently with dose but Cd levels did increase with gestational age. Placental to maternal blood Cd concentration ratios increased with gestational age but not with dose. Maternal liver to fetal liver concentration ratios were 295, 137, and 27 for low, middle and high doses, respectively, 24 hr after pregnant rats were treated on day 20 of gestation. These results are discussed in relation to placental damage, metallothionein inducibility, and fetotoxicity.
Dit Dit
Authors: Maria L. Evans
Journal: JAMA (1990)

A mere pair of "dits" conveys a lot of meaning to an experienced ham radio operator. Superficially, they're the Morse code version of "shave and a haircut—six bits." At the end of a telegraphic contact, the first operator sends "dit di-di dit dit." The listening op replies, "dit dit." To hams, "dit dit" can mean myriad things—from "stand by, I'm looking for a pencil" to a shortened version of "hi hi" (the telegraphic "ha ha"). Say one operator gets a phone call. Hearing silence, the other op sends "?"—di-di dah dah di-dit. The ham on the phone casually reaches for the key and taps, "dit dit."<i>I'm here. No need to worry. The electricity didn't go out, I'm not having a heart attack. Dit dit. I'm still with you. You're not alone</i>. Close ham radio friends often make daily or weekly "skeds," or schedules, on a certain frequency at a
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Authors: Masayuki Iwano, David Plieth, Theodore M. Danoff, Chengsen Xue, Hirokazu Okada, Eric G. Neilson
Journal: Journal of Clinical Investigation (2002)

Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver. While some view fibroblasts in adult tissues as nothing more than primitive mesenchymal cells surviving embryologic development, they differ from mesenchymal cells in their unique expression of fibroblast-specific protein-1 (FSP1). This difference raises questions about their origin. Using bone marrow chimeras and transgenic reporter mice, we show here that interstitial kidney fibroblasts derive from two sources. A small number of FSP1+, CD34– fibroblasts migrate to normal interstitial spaces from bone marrow. More surprisingly, however, FSP1+ fibroblasts also arise in large numbers by local epithelial-mesenchymal transition (EMT) during renal fibrogenesis. Both populations of fibroblasts express collagen type I and expand by cell division during tissue fibrosis. Our findings suggest that a substantial number of organ fibroblasts appear through a novel reversal in the direction of epithelial cell fate. As a general mechanism, this change in fate highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions.
A LARGE PERFORATION IN THE SINUS PIRIFORM DURING ZENKER DIVERTICULOTOMY EFFECTIVELY CLOSED WITH “CLIPS-AND-RUBBER BAND” TECHNIQUE
Authors: M Pioche, J Rivory, JC Saurin, T Ponchon
Journal: Endoscopy (2019)

Endoscopic treatment of Zenker diverticulum (ZD) by diverticulotomy consists in cutting the septum between the esophageal lumen and the diverticulum, thus restoring bolus transit. This technique is being increasingly preferred to surgical treatment as it is safe and minimizes the in-hospital stay, especially in patients with important comorbidities [1,2]. Nevertheless, endoscopic diverticulotomy carries a risk of perforation and delayed bleeding [1].
Pubertal Presentation in Seven Patients with Congenital Adrenal Hyperplasia due to P450 Oxidoreductase Deficiency
Authors: Jan Idkowiak, Stephen O'Riordan, Nicole Reisch, Ewa M. Malunowicz, Felicity Collins, Michiel N. Kerstens, Birgit Köhler, Luitgard Margarete Graul-Neumann, Maria Szarras-Czapnik, Mehul Dattani, Martin Silink, Cedric H. L. Shackleton, Dominique Maiter, Nils Krone, Wiebke Arlt
Journal: Endocrine Reviews (2011)

P450 oxidoreductase (POR) is a crucial electron donor to all microsomal P450 cytochrome (CYP) enzymes including 17α-hydroxylase (CYP17A1), 21-hydroxylase (CYP21A2) and P450 aromatase. Mutant POR causes congenital adrenal hyperplasia with combined glucocorticoid and sex steroid deficiency. P450 oxidoreductase deficiency (ORD) commonly presents neonatally, with disordered sex development in both sexes, skeletal malformations, and glucocorticoid deficiency. The aim of the study was to describe the clinical and biochemical characteristics of ORD during puberty. Clinical, biochemical, and genetic assessment of seven ORD patients (five females, two males) presenting during puberty was conducted. Predominant findings in females were incomplete pubertal development (four of five) and large ovarian cysts (five of five) prone to spontaneous rupture, in some only resolving after combined treatment with estrogen/progestin, GnRH superagonists, and glucocorticoids. Pubertal development in the two boys was more mildly affected, with some spontaneous progression. Urinary steroid profiling revealed combined CYP17A1 and CYP21A2 deficiencies indicative of ORD in all patients; all but one failed to mount an appropriate cortisol response to ACTH stimulation indicative of adrenal insufficiency. Diagnosis of ORD was confirmed by direct sequencing, demonstrating disease-causing POR mutations. Delayed and disordered puberty can be the first sign leading to a diagnosis of ORD. Appropriate testosterone production during puberty in affected boys but manifest primary hypogonadism in girls with ORD may indicate that testicular steroidogenesis is less dependent on POR than adrenal and ovarian steroidogenesis. Ovarian cysts in pubertal girls may be driven not only by high gonadotropins but possibly also by impaired CYP51A1-mediated production of meiosis-activating sterols due to mutant POR.
711 Medical Maxims
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Synchrony of malignant lymphoma and breast cancer
Authors: M. Stierer
Journal: JAMA (1990)

PRIMARY malignant lymphoma of the breast is a rare disorder. In a statistical review, the incidence of this entity associated with other malignant tumors of the breast has been reported as 0.14%.<sup>1</sup>Manifestations of malignant lymphoma of the breast are predominantly extranodal, in the form of stage I E disease, according to the Ann Arbor classification. While spread of the lymphoma has been reported to progress from the breast into the regional lymph nodes (stage II E, Ann Arbor), no instance of the reverse process (axilla to breast) has been described.<sup>1</sup> We report the synchronous occurrence of axillary malignant lymphoma and carcinoma of the breast metastasizing into the ipsilateral axilla. <h3>Report of Cases</h3><h3>Case 1. —</h3> A 66-year-old woman noted a cherry-sized painless lump in the laterocranial quadrant of the right breast, which had persisted for the past 2 weeks, accompanied by a dragging sensation in the right
Spontaneous retroperitoneal hematoma. A complication of hemodialysis
Authors: S. Vanichayakornkul
Journal: JAMA (1974)

Spontaneous retroperitoneal hematomas developed in two patients on long-term dialysis. In one, a femoral nerve palsy resulted. Recovery was slow, but complete. The second patient had the manifestations of obstructive jaundice. Diagnosis was made surgically, the hematoma was evacuated, and the obstruction was relieved. (<i>JAMA</i>230:1164-1165, 1974)
Surgical or Medical Management of Asthma?
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
METABOLIC CONSEQUENCES OF FASTING
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Non-invasive tests predict the risk of hepatocellular carcinoma in hepatitis C patients after sustained virological response: impact on HCC surveillance
Authors: Javier Ampuero, Isabel Carmona, Jose Miguel Rosales Zabal, Marta Casado, Manuel De La Mata Garcia, Aida Ortega-Alonso, Yolanda Sánchez, Patricia Cordero Ruiz, Matias Estevez, Raul J. Andrade, Manuel Romero Gomez
Journal: Journal of Hepatology (2020)
Study of ?hepatotrophic? substances after portal branches ligation in the rat . Lab. of Experimental Surgery, University of Louvain, Brussels, Belgium
Journal: Hepatology (1995)

IR, Raman and single-crystal Raman spectra of laurionite-type Sr(OH)I, Ba(OH)Cl, Ba(OH)Br, Ba(OH)I, Pb(OH)Cl, Pb(OH)Br and Pb(OH)I, and of deuterated specimens and Ba(OH)Cl1−xBrx, solid solutions recorded at 90–520 K are presented and assigned to OH (OD) stretching, librational and translational modes. The main results obtained are (i) unusually large structural H/D isotope effects of Ba(OH)Cl due to Landau-type isostructural reorientation of OH− ions and (ii) the very different nature and strengths of the hydrogen bonds formed. Thus, the strengths of the partly linear (Ba(OH)Cl), partly multifurcated hydrogen bonds range as Pb(OH)I (vOH: 3497 cm−1) > Pb(OH)Br > Pb(OH)Cl > Sr(OH)I (3591 cm−1), as shown by the red-shift of the OH stretches and the blue-shift of the OH librations. In the cases of Ba(OH)Br (3605 cm−1) and Ba(OH)I (3590 cm−1), hydrogen bonding is negligible. The stronger hydrogen bonds formed in the lead compounds are caused by the greater synergetic effect of Pb2+ ions compared to those of Sr2+ and Ba2+.
Which birth weight standards?
Journal: BMJ (1978)

estimations must be corrected for temperature.There is no evidence that the routine use of intravenous fluids, steroids, liothyronine, or vasoactive drugs is helpful.Nevertheless, because hypothermic patients tend to develop lung infections after rewarming, there may be a case for giving a prophylactic loading dose of a broad-spectrum antibiotic at once, but then not again until the temperature rises above 32°C.The mortality rates using this kind of regimen in the largest series are still about 50%,19 22 but many of the elderly patients die not from hypothermia but from the illness that precipitated 1
STATE LICENSE STATISTICS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ITALY
Journal: JAMA (1933)

<h3>Congress of Internal Medicine</h3> The thirty-seventh Congresso nazionale di medicina interna was held in Rome under the chairmanship of Prof. Edoardo Maragliano. <h3>ARTERIAL HYPERTENSION</h3> Professor Greppi of Milan discussed "Arterial Hypertension as an Independent Dysfunction and Disease," bringing out particularly, in his paper the difference between hypertensive excitability and the hypertensive state. The primary factor that sustains the arterial pressure and maintains it at a normal level in the adult is the tonus of the sympathetic nervous system, which is accomplished through the stimulating influence of the chemical composition of the blood (carbon dioxide) on the vasoconstrictive centers, and this, in turn, determines the tonus of the parasympathetic system, which exerts a hypotensive influence. The clinical aspects of hypertension are many. Young persons with hypertension show usually an increase in the glycemic index and fluctuations in the blood sugar level from one moment to the next. Lecithinemia tends also to
Epidemiology Study of the Use of Asbestos-Cement Pipe for the Distribution of Drinking Water in Escambia County, Florida
Authors: James R. Millette, Gunther F. Craun, Judy A. Stober, Dale F. Kraemer, H. G. Tousignant, Ellen Hildago, Robert L. Duboise, Jeffrey Benedict
Journal: Environmental Health Perspectives (1983)

Cancer mortality for the population census tracts of Escambia County, FL, which use asbestos-cement (AC) pipe for public potable water distribution, was compared with cancer mortality data collected from census tracts in the same county where other types of piping materials are used. An analysis of covariance was run to test for differences in standard mortality ratios for seven cancer sites among three potential asbestos exposure groups based on AC pipe usage. Twelve variables representing nonexposure-related influences on disease rates were combined in four independent factors and used as covariates in these analyses. No evidence for an association between the use of AC pipe for carrying drinking water and deaths due to gastrointestinal and related cancers was found. The limitations on the sensitivity of the analysis are discussed.
Brain and Spinal Cord.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Periosteal elevation in a 2 1/2-year-old child
Authors: J. A. Smith
Journal: JAMA (1976)

<h3>History</h3> A 2 1/2-year-old boy complained of pain below the knee and had diffculty walking. Initial examination showed pain and redness over the right proximal tibia. The patient had a low-grade fever. The white blood cell count was 11,000/cu mm. Figure 1 was obtained soon after onset; Fig 2 and 3, three weeks later. <h3>Diagnosis</h3> Stress fracture. <h3>Comment</h3> The initial roentgenogram (Fig 1) showed no positive findings. Roentgenograms made three weeks later (Fig 2 and 3) showed periosteal elevation with subperiosteal new bone and a sclerotic line crossing the proximal tibia, indicating a healing fracture. Stress fractures occurring in young adults, especially military recruits, have been described in the literature as early as the mid-19th century.<sup>1</sup>Similar fractures in children younger than 10 years old have rarely been recorded. Often, the clinical findings and roentgenographic appearance lead to an erroneous diagnosis of either tumor or inflammation in these children.
Poplar demand.
Authors: W C Holton
Journal: Environmental Health Perspectives (1998)

Trichloroethylene (TCE) is a common industrial solvent that poses a particular pollution problem in groundwater; while TCE disappears from surface water within a few weeks, groundwater contamination can take months or years to degrade. Humans have not conclusively been shown to develop cancer in response to TCE exposure, but rats and mice exposed to TCE have an increased incidence of liver and lung cancers.