tbuckley/cabot-search huggingface dataset:
Denial
Authors: Ranjana Srivastava
Journal: New England Journal of Medicine (2009)

The medical student is watching closely. In an overfilled clinic, time is scarce and the teaching staccato. I point out a malignant lymph node here, an enlarged liver there. She witnesses the abbreviated version of my breaking bad news and I hope finds some parallel with what she has been taught. I try to offer her a window into my thinking, as I talk patients into and out of having chemotherapy. Then I pick up an unfamiliar file. In response to an urgent request from her primary care doctor, the patient has been sandwiched into a virtual slot. Ushering her . . .
The declining length of hospitalization for tubal sterilization
Authors: P. M. Layde
Journal: JAMA (1981)

We analyzed factors affecting the length of hospital stay for tubal sterilization in 1970 and 1975, using data from the National Center for Health Statistic's Hospital Discharge Survey. The average hospital stay for tubal sterilization declined from 6.5 nights in 1970 to 4.0 nights in 1975. Pregnancy status, region of residence, and race were important determinants of the length of hospital stay. One technological innovation, the use of the laparoscope for tubal sterilization, accounted for 39% of the total length-of-stay reduction from 1970 to 1975. General changes in medical care from 1970 to 1975, combined with the introduction of laparoscopy, averted 1,363,000 nights of hospitalization for tubal sterilization in 1975. Conservatively, this resulted in a savings of more than $200 million. About $80 million of this savings was directly attributable to laparoscopy. Even greater savings could have been achieved if sterilization techniques requiring shorter hospital stays had been more widely used. (<i>JAMA</i>1981;245:714-718)
All other Clinical Studies
Authors: T Reilly, V Poxon, Walt Rp, E Trespi, L Villani, F Broglia, C Luinetti, R Colla
Journal: Gut (1995)

AIM: to compare the performance of different eradication regimens in the everyday management of Helicobacter-positive peptic ulcer.Between February 1 1992 and February 10 1995, 668 unselected patients with proven peptic ulcer (467 males, 201 females, median age 53, range 18-83) of whom 574 had duodenal ulcer (4 perforations, 3 GI bleeds), 78 gastric ulcer, 13 both, 3 unspecified, underwent a course of eradication therapy and had a subsequent 13C-urea breath test at least 4 weeks after finishing.Age, date, type of treatment, test result and side- effects were recorded.The main therapeutic regimens were as follows: Regimen Eradicated Failed Rate (%6) 95% Cl OAMI 339 65 83.9 80.3-87.5 S1T2 149 46 76.4 70.5-82.4OACI 19 0 100 82.4-100 Overall 544 124 81.4 78.5-84.4tomeprazole 20mg bd, amoxycillin 500mg tds and metronidazole 400mg for one week.tStandard triple therapy of colloidal bismuth 120mg qds, amoxycillin 500mg qds or tetracycline 500mgtds and metronidazole 500mg tds.lomeprazole 20mng bd, amoxycillin 500mg tds and clarithromycin 250mg tds 400mg for one week, all patients in whom previous courses had failed.Side effects (diarrhoea, rash and headache) were reported in 205/668 (30.6%) and the incidence was the same in treatment successes and failures (31% and 30%, NS).CONCLUSIONS: Simple one week Helicobacter pylori eradication regimens are successful in everyday practice, and a one week course not containing metronidazole was highly successful in those whose treatment had failed.
Coxsackievirus B epidemic at a Boy's Summer Camp. Isolation of virus from swimming water
Authors: H. B. Hawley
Journal: JAMA (1973)

During an outbreak of coxsackievirus B5 at a boys' summer camp located on Lake Champlain, virus was successfully isolated for the first time (to our knowledge) from a large body of recreational water. This was accomplished by using polyelectrolyte 60 to concentrate the virus. Polyelectrolyte 60 was also used in the isolation of viruses from clinical specimens obtained from campers and staff who had a wide variety of clinical syndromes. Virus present in lake swimming water may play an important role in some enterovirus outbreaks.
A Practical Handbook on the Muscular Anomalies of the Eye.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neonatal Polycystic Kidney with Brain Defect
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians' and Students' Ready Reference Series: Synopsis of Human Anatomy.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal pain in childhood is linked with psychiatric disorders in adulthood
Journal: BMJ (1998)

Early selegiline treatment in Parkinson's disease may not be advantageous A previous report from the UK Parkinson's Disease Research Group's randomised controlled trial noted that patients with early, mild Parkinson's disease treated with selegiline and levodopa (arm 2) had around 60% increased mortality compared with those given levodopa alone (arm 1).On p 1191 Ben-Shlomo et al examined whether this increased mortality was maintained and tested possible explanations such as orthostatic hypotension, more rapidly deteriorating disease, and adverse drug interactions with other drugs.The extended results show a persistent but smaller excess mortality with combined treatment.Patients who died in arm 2 were more likely to have had possible dementia before death.The results do not support the use of combined treatment in newly diagnosed disease.In more advanced disease its avoidance in patients with postural hypotension, frequent falls, confusion, and dementia may be advisable.
Fatal Mumps Meningoencephalitis
Authors: Bruce Bistrian
Journal: JAMA (1972)

Mumps virus was recovered from both premortem cerebrospinal fluid and postmortem testicular tissue obtained from an 8-year-old boy with fatal meningoencephalitis. There was histologic evidence of both primary encephalitis with acute invasion of the central nervous system by virus and secondary postinfectious encephalitis with demyelination. With a safe and effective live, attenuated mumps vaccine available, a reappraisal of its place in immunization schedules is urged.
Abstract 3851: Protein switches that activate a prodrug in the presence of HIF-1a
Authors: Chapman M. Wright, James Eshleman, Marc Ostermeier
Journal: Cancer Research (2010)

Abstract We have engineered yeast cytosine deaminase (CD) to be activated by the tumor marker, hypoxia-inducible factor 1-alpha (HIF-1a) - turning on its ability to convert 5-fluorcytosine (5FC) into the anticancer drug 5-fluoruracil (5FU). HIF-1a is overexpressed in many types of cancer but is virtually undetectable in normal tissue due to rapid degradation. We sought a “tumor-sensing” protein whose prodrug converting activity is activated in the presence of HIF-1a. Such a protein could be used in a therapeutic treatment similar to gene-directed enzyme prodrug therapy (GDEPT). However, our approach would have an advantage over GDEPT because the “suicide” gene could be delivered using very efficient methods for gene delivery, whether or not they were selective, since the selectivity occurs at the protein level and not the gene delivery level. To create our desired protein, we constructed a library of fusion proteins between CD and the CH1 domain of p300 - a domain known to interact with HIF-1a. This library was subjected to a two-tiered genetic selection in E. coli designed to identify genes that conferred increased sensitivity to 5FC when HIF-1a was co-expressed. We identified two library members (#3 and #59), which conferred to E. coli sensitivity to 5FC equivalent to wildtype CD but only in the presence of co-expressed HIF-1a. In the absence of HIF-1a, #3 conferred a 5-fold higher LC50 to 5FC and #59 did not confer any sensitivity to 5FC. Both proteins were purified and characterized in vitro for their activity in the presence and absence of HIF-1a. Protein #3 exhibited a 4-fold increase in its CD activity in the presence of HIF-1a, whereas protein #59's activity did not have a significant dependence on HIF-1a. Currently, the two genes are being examined in human cancer cell lines for their ability to confer sensitivity to 5FC in the presence of HIF-1a. Using advanced protein engineering techniques, we have created two proteins that confer sensitivity to 5FC in the presence of the tumor-marker, HIF-1a. We believe that these genes have therapeutic potential for the treatment of cancers that exhibit elevated HIF-1a levels. Our strategy circumvents a limitation of GDEPT by not requiring selective delivery of the gene to cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3851.
NERVE GASES
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical abortion.
Authors: B. Grant
Journal: BMJ (1992)

and placenta are identified in the four hours after the administration of the prostaglandin, it provides an opportunity for counselling and contraceptive advice as well as ensuring that the abortion has been completed.Ultrasound scanning is necessary only in those women in whom there is doubt as to whether the abortion is complete (<5%).Thus the number of clinic visits is no more than should be offered to a woman who has chosen vacuum aspiration.Unlike after vacuum aspiration, access to medical theatre and skilled medical and paramedical staff is required for only a small percentage (about 5%) of women after medical abortion.Though it is prudent to ensure that medical abortion is both safe and effective, it would be a pity if this choice was not made available to women because the estimates of the cost have been based on overelaborate facilities.
Book Review Handbook of Growth Factors: General basic aspects (Vol. I.) By Enrique Pimentel. 370 pp. Boca Raton, Fla., CRC Press, 1994. $85. 0-8493-2505-6 Handbook of Growth Factors: Peptide growth factors (Vol. II.) By Enrique Pimentel. 362 pp. Boca Raton, Fla., CRC Press, 1994. $85. 0-8493-2506-4 Handbook of Growth Factors: Hematopoietic growth factors and cytokines (Vol. III.) By Enrique Pimentel. 370 pp. Boca Raton, Fla., CRC Press, 1994. $85. 0-8493-2507-2
Authors: James W. Mier
Journal: New England Journal of Medicine (1995)
Pathologic Changes Following Chronic Exposures to Halothane: A Review
Authors: Louis W. Chang
Journal: Environmental Health Perspectives (1977)

The toxic effects of halothane on the liver, kidney, and brain are reviewed. Increasing evidence has indicated that hepatic degeneration can be induced in several animal speices after exposure to halothane. Recent electron microscopic investigations have also revealed cytological degeneration of the liver cells after chronic exposure to subclinical levels of halothane. Degeneration of the kidney and the nervous system after halothane exposure have also been reported. The pathological effects of halothane on the neonatal (developing) liver, kidney, and brain are also demonstrated by electron microscopy. Although the full significance of these observations on experimental animals in relationship to human exposure is still not known, the indication of the toxic potential of halothane on the biological system is strong and deserves further investigation.
A COMMEMORATION OF LISTER'S WORK.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laser Injuries
Authors: Norman C. Telles
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Laser devices are being used increasingly in artistic and entertainment displays, such as laser art sculpture, discotheque displays, planetarium laser shows, and accompaniment to musical concerts, specifically rock concerts. This has raised serious concerns about hazards to the public and users of laser devices. The purpose of this communication is to alert the medical practitioners, specifically ophthalmologists, and request their help in locating and evaluating any cases of injury that may have resulted from exposure at a laser show. For visible laser radiation, biologic damage has not been established for power levels below 0.39 μW. For power levels up to 1 mW, eye damage from long exposure is possible. For power levels above 1 mW, injury is possible from brief, direct exposure; for example, argon and helium-neon laser beams with power levels from 2 mW to 17.5 mW can cause retinal lesions in test animals after 1-second
National Standards for Diabetes Self-Management Education
Authors: Carolé Mensing, Jackie Boucher, Marjorie Cypress, Katie Weinger, Kathryn Mulcahy, Patricia Barta, Gwen Hosey, Wendy Kopher, Andrea Lasichak, Betty Lamb, Mavourneen Mangan, Jan Norman, Jon Tanja, Linda Yauk, Kimberlydawn Wisdom, Cynthia Adams
Journal: Diabetes Care (2005)
On the Use of Massage and Early Passive Movements in Recent Fractures and other Common Surgical Injuries and the Treatment of Internal Derangement of the Knee-Joint. Three Clinical Lectures Delivered at St. George's Hospital.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Follow-up status of patients with angiographically normal coronary arteries and panic disorder
Authors: B. D. Beitman
Journal: JAMA (1991)

Cardiology patients with normal coronary angiography demonstrate continuing and substantial social, health, and work disability. We hypothesized that the diagnosis of panic disorder would mark those for whom continuing disability is most likely. We interviewed 72 such patients at the time of their normal angiogram, and then again an average of 38 months later. Those with panic disorder (n = 36) demonstrated significantly more disability at follow-up than did the other study patients. We conclude that those patients with normal angiograms who have panic disorder are more disabled than those who do not have panic disorder. Panic disorder in psychiatric samples has been shown to be highly treatable. Therefore, early identification and treatment of panic disorder in this group is likely to minimize the suffering associated with this condition. (<i>JAMA</i>. 1991;265:1545-1549)
A3.2 Anti-citrullinated proteins antibodies promote synovial fibroblast migration in rheumatoid arthritis
Authors: M Sun, V Joshua, AH Hensvold, SB Catrina, V Malmström, K Amara, H Wähämaa, AI Catrina
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> The presence of anti-citrullinated proteins antibodies (ACPAs) in RA is associated with aggressive disease phenotype and bone destruction. As synovial fibroblasts (SFs) are considered key players of both synovial inflammation and bone destruction in rheumatoid arthritis (RA), we studied the effect of ACPAs on fibroblasts migration. <h3>Methods and materials</h3> Human dermal fibroblasts (HDFs) were obtained from PromoCell. SFs were isolated from synovial tissue of RA patients (RASFs) by enzymatic digestion. ACPA positive and negative IgGs were separated from plasma of RA patients and monoclonal anti-citrullinated antibodies were generated from synovial fluid by single B-cells. Migration scratch assays were performed using either RASFs or HDFs to test the effect of ACPAs, anti-citrullinated protein monoclonal antibodies and appropriate negative controls. The effect of a phosphatidylinositide 3-kinase (PI3K) inhibitor (wortmanin), G-protein coupled receptor (GPCR) inhibitor (pertussis toxin), focal adhesion kinase (FAK) inhibitor (PF-573228) and Protein-arginine deiminase (PAD) inhibitor (Cl-Amidine) was tested. Light microscopy images were taken at base line and after 6 h incubation and analysed using NIH ImageJ to calculate migration index. Cytotoxicity and proliferation assay were done in parallel with migration assays. <h3>Results</h3> ACPAs but not others IgGs than ACPAs induced a 3.9 ± 0.5 (mean ± SD) fold increase in HDFs and a 2.6 ± 0.5 (mean ± SD) fold increase in RASFs migration (p &lt; 0.05). GPCR blocking completely abolished ACPAs effects. PI3K but not FAK blocking abolished ACPAs effects, with minimal residual fold increase of 1.4 ± 0.4 (mean ± SD). Inhibition experiments suggest that ACPAs mediated RASFs migration via GPCR-PI3K pathway. Pre-inactivated PAD totally abolished ACPAs effects suggesting that citrullination is crucial for ACPAs mediated RASFs migration. No difference in either cytotoxicity or proliferation rate were observed between different treatments. One out of three different anti-citrullinated monoclonal antibodies displayed similar migration promoting effects. <h3>Conclusion</h3> We describe a novel effect of ACPAs, providing a link between synovial fibroblasts and the adaptive immune system. We further suggest that different fine specificities of the ACPAs might have distinct impact on disease pathogenesis.