tbuckley/cabot-search huggingface dataset:
PATHOLOGIC RELATIONSHIPS OF THE BLOOD VOLUME IN INFANCY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Self-Induced Water Intoxication. Case Study of a Chronically Schizophrenic Patient with Physiological Evidence of Water Retention due to Inappropriate Release of Antidiuretic Hormone
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical schools in Canada
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Encore
Authors: None Gemaennes
Journal: Annals of the Rheumatic Diseases (1990)

EncoreThe erythrocyte sedimentation rate (ESR) and rheumatoid arthritis Dr Bull and his colleagues suggested in a paper published in the Lancet (1989; ii: 965) that the ESR is probably the best guide for assessing disease activity in rheumatoid arthritis.Three subsequent letters in that journal disagree with them.The authors of these letters variously contend that the ESR is not a good predictor of disease outcome, that there is no direct relation between the ESR level and the degree of synovitis, that other methods of measuring the ESR may be better, and that the way drug treatment influences ESR levels may be different from the anti-inflammatory mech- anism.No doubt the controversy will continue.
Hemoglobin Heterogeneity
Authors: H. Franklin Bunn
Journal: New England Journal of Medicine (1971)

Structural differences may occur between comparable proteins of the fetus and adult. A well studied example is the transition from hemoglobin F (α2γ2) to hemoglobin A (α2β2). The γ chain has considerable structural homology with the β chain, differing in 39 out of 146 amino acids. As the fetus approaches term, γ-chain synthesis is suppressed as β-chain synthesis is initiated. After the first few months of life, hemoglobin F normally comprises less than 1 per cent of the red-cell hemoglobin. The identification and quantitation of this hemoglobin has been useful in the . . .
Parenting groups reduce antisocial behaviour in children
Journal: BMJ (2001)

Evidence on health effects of housing improvements is scarce Despite strong observational evidence linking housing and health, it is still not known if housing improvements can improve health.Thomson et al (p 187) conducted a systematic review of studies of housing interventions on health.Although many of the studies found that health improved after the interventions, the studies were small and often did not adjust for potential confounding factors.
Low frequency of precore hepatitis B virus mutants in anti-hepatitis B e-positive reactivation after loss of Hepatitis B e antigen in patients with chronic Hepatitis B*1
Authors: M LORIOT
Journal: Hepatology (1995)

The objective of this study was to evaluate the role of hepatitis B virus (HBV) precore mutations in patients with anti-HBe-positive chronic hepatitis B with or without previous known HBe antigen (HBeAg) viremic phase, and to assess the potential implication of precore mutants in HBeAg—negative reactivation after loss of HBeAg. Nineteen patients were studied: 7 had a previous HBeAg-positive phase and had spontaneous or therapeutically induced loss of HBeAg (group A); 12 had no previous HBeAg-positive phase (group B). Direct sequencing of PCR products was performed on serum collected during the anti-HBe-positive phase in the two groups. In group A, precore sequencing showed that 5 patients were infected by wild-type virus, 1 patient was infected with a precore mutant, and 1 patient was found to be infected by a mixture of wild-type and precore mutant viruses. In group B, precore sequencing showed that only 1 patient was infected with wild-type virus and that 11 were infected with precore mutants. In a few patients, the presence of HBeAg within immune complexes may explain HBeAg negativity. In conclusion, our results show that, in patients with anti-HBe-positive chronic hepatitis B: (1) precore mutations creating a stop codon are more frequently found in those without known previous HBeAg positivity; (2) after loss of HBeAg, the patients who have anti-HBe-positive reactivation are infected by wild-type virus, which suggests that reactivation is not related to precore mutations; (3) HBeAg negativity may be caused by immune complexes formation.
Gianotti-Crosti syndrome associated with infections other than hepatitis B
Authors: Z. K. Draelos
Journal: JAMA (1986)

Although the Gianotti-Crosti syndrome (GCS) is regularly associated with hepatitis B infection elsewhere, in North America that association is rarely made. Accordingly, we studied nine children with acral, symmetrical eruptions typical of GCS for evidence of other infections. All were negative for hepatitis B surface antigen. Viral cultures were done in nine patients, and viruses isolated in two. One patient with a respiratory prodrome had respiratory syncytial virus (RSV) isolated, and a second patient studied simultaneously showed serological evidence of RSV infection. A third patient with both respiratory tract and gastrointestinal tract symptoms yielded a polio-vaccine enterovirus. Two patients with fever and pharyngitis had group A βhemolytic streptococci isolated from the throat. Skin biopsies were done in three cases, and findings were consistent with GCS. Electron microscopy of two lesional biopsy specimens failed to demonstrate viral particles. Epstein-Barr virus serological findings were negative in six cases and showed evidence of past infection in three cases. This study strengthens the observation that hepatitis B is not the causative agent of GCS in this country and suggests that multiple infectious agents may be associated with this distinctive exanthem. (<i>JAMA</i>1986;256:2386-2388)
Microsporidia and HIV-related Diarrhea
Authors: Linda Rabeneck
Journal: Annals of Internal Medicine (1994)

Letters1 June 1994Microsporidia and HIV-related DiarrheaLinda Rabeneck, MD, MPH and Robert M. Genta, MDLinda Rabeneck, MD, MPHHouston Veterans Affairs Medical Center; Houston, TX 77030Search for more papers by this author and Robert M. Genta, MDHouston Veterans Affairs Medical Center; Houston, TX 77030Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-11-199406010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:With respect to the clinical course of E. bieneusi-infected men, after a mean of 15 months of follow-up, the 18 men with chronic diarrhea retained this pattern, and 2 of the 13 asymptomatic men developed intermittent diarrhea (unpublished data). Histologic findings varied from normal architecture to almost complete effacement of the villous architecture (unpublished data). We do not agree with Orenstein and colleagues' statement correlating parasite burden and the severity of diarrhea. Such a correlation requires a valid and reliable method for assessing parasite burden, which is not currently available. Classifying the degree of mucosal damage on the ...References1. Orenstein JM, Tenner M, Kotler DP. Localization of infection by the microsporidian Enterocytozoon bieneusi in the gastrointestinal tract of AIDS patients with diarrhea. AIDS. 1992; 6:195-7. Google Scholar2. Gourley WK, Swedo JL. Intestinal infection by microsporidia Enterocytozoon bieneusi of patients with AIDS: an ultrastructural study of the use of human mitochondria by a protozoan (Abstract). Lab Invest. 1988; 58:35A. Google Scholar3. Rabeneck L, Gyorkey F, Genta RM, Gyorkey P, Foote LW, Risser JM. The role of Microsporidia in the pathogenesis of HIV-related diarrhea. Ann Intern Med. 1993; 119:895-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Houston Veterans Affairs Medical Center; Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFibromyalgia Review 1 June 1994Volume 120, Issue 11Page: 973-974KeywordsBiopsyChronic diarrheaDiarrheaElectron microscopyLearning curvesLesionsLight microscopyMicrosporidiaMicrosporidiosisPathologists Issue Published: 1 June 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Possible Relevance of Pigeons as an Indicator Species for Monitoring Air Pollution
Authors: Pauline A. E. L. Schilderman, Jurian A. Hoogewerff, Frederik-Jan van Schooten, Lou M. Maas, Edwin J. C. Moonen, Bertil J. H. van Os, Joop H. van Wijnen, Jos C. S. Kleinjans
Journal: Environmental Health Perspectives (1997)

Wild city pigeons were caught at four different locations in the Netherlands to represent areas of high (Amsterdam-high), moderate (Amsterdam-medium), and low (Maastricht and Assen) traffic density. It is assumed that local ambient air pollution decreases as a function of traffic density. In these pigeons levels of polycyclic aromatic hydrocarbon (PAH)-DNA adducts, oxidative DNA damage, and heavy metal residues were determined in kidney, lung, liver, and blood (no adduct analysis in blood). The contribution of leaded gasoline to total body lead content was estimated by measuring concentrations of Pb and its isotopes in blood. We also analyzed samples of ambient air particulate matter for PAH and heavy metal concentrations at the four different locations. Interregional differences in heavy metals in ambient air particulate matter were reflected relatively well by pigeon body loads. The higher lead and cadmium concentrations in blood, kidney, liver, and lung were found in the Amsterdam high traffic density area, followed by Amsterdam medium, Assen, and Maastricht. A high Pb concentration in blood coincided with relatively low 206Pb/207Pb values, indicating a high contribution of leaded gasoline to total blood Pb concentrations in pigeons from the Amsterdam high traffic density area. Significantly enhanced blood zinc values were found in pigeons from both locations in Amsterdam compared to pigeons from the other two areas. However, no differences in Zn tissue levels between the four different groups were found. Oxidative DNA damage, determined as the ratio of 7-Hydro-8-oxo-2'-deoxyguanosine/ deoxyguanosine, in pigeon liver was highest in Amsterdam-high, followed by Assen (low traffic density). Pb content, but not the Cd content, was positively associated with oxidative DNA damage in liver tissue. In lung tissue, a negative correlation was found between oxidative DNA damage and Zn content. These results indicate that the carcinogenic potential of Pb might be ascribed to oxygen radical formation, whereas Zn plays a protective role against oxidative DNA damage. Places with high and medium traffic density could be clearly discriminated on the basis of PAH levels in the ambient air. The PAH content in particulate air samples was not, however, reflected in total PAH-related DNA adduct levels because no differences could be observed in tissue adduct levels in pigeons from the four different locations. Our results indicate that wild city pigeons can be used as biological indicators of exposure to heavy metal pollution in outdoor air.
Errors in the Abstract Results; Results; Tables 1, 4, and 5; the Conflict of Interest Disclosures; and the Supplement
Journal: JAMA Network Open (2021)

Shelley S. Magill, MD, PhD; Erin O’Leary, MPH; Susan M. Ray, MD; Marion A. Kainer, MBBS, MPH; Christopher Evans, PharmD; Wendy M. Bamberg, MD; Helen Johnston, MPH; Sarah J. Janelle, MPH; Tolulope Oyewumi, MD, MPH; Ruth Lynfield, MD; Jean Rainbow, MPH, RN; Linn Warnke, RN, MPH; Joelle Nadle, MPH; Deborah L. Thompson, MD, MSPH; Shamima Sharmin, MBBS, MSc, MPH; Rebecca Pierce, PhD, MS, BSN; Alexia Y. Zhang, MPH; Valerie Ocampo, MIPH, RN, BSN; Meghan Maloney, MPH; Samantha Greissman, MD, MPH; Lucy E. Wilson, MD, ScM; Ghinwa Dumyati, MD; Jonathan R. Edwards, MStat; Nora Chea, MD, MS; Melinda M. Neuhauser, PharmD, MPH; Emerging Infections Program Hospital Prevalence Survey Team
Acute Hepatitis and the Lupus Erythematosus Phenomenon
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
光学相干断层成像术用于诊断 BCC
Authors: N. Reddy, B.T. Nguyen
Journal: British Journal of Dermatology (2019)

基底细胞癌(BCC)是世界上最常见的皮肤癌形式。在过去 40 年中, 此病在欧洲的发病率正以每年 5.5% 的惊人速度增加。在英国, BCC 发病率的增速是欧洲其他国家的6 倍。BCC 的诊断通常需要皮肤活检和在显微镜下进行仔细的分析。光学相干断层成像术(OCT) 是一种无需进行皮肤活检,通过光来实时显现皮肤表面下层次的成像工具。认为它是诊断BCC 的一种无创备选工具。这项来自美国的研究调查了当前文献, 以全面评估OCT 技术在评估 BCC 方面的准确性。作者们回顾了采集自31 项使用OCC 诊断BCC 的研究中的 901 例BCC。作者们发现 OCT 可以诊断BCC, 灵敏度为 89.3%,意味着在每 10 例 BCC 中可正确发现9 例。在不同类型的OCT 中, 最先进的傅立叶‐域 OCT 获得了最高的准确度。OCT 可以在高达80% 的肿瘤中检测出通常在显微镜下可见的BCC 特征。此外, 作者们指出, OCT 在预测深度小于 1 mm 的浅部BCC 肿瘤方面表现最佳。根据这些结果, 作者们预测OCT 是一种宝贵的无创 BCC 诊断工具。
Re: K. Hatzimouratidis, I. Eardley, F. Giuliano, et al. Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation. The Netherlands: European Association of Urology; 2015. http://uroweb.org/guideline/male-sexual-dysfunction/
Authors: Vincenzo Puppo, Giulia Puppo
Journal: European Urology (2015)
First-line pazopanib in non-clear cell renal carcinoma: The Italian retrospective multicenter PANORAMA study.
Authors: Sebastiano Buti, Melissa Bersanelli, Francesca Maines, Gaetano Facchini, Francesco Gelsomino, Fable Zustovich, Matteo Santoni, Elena Verri, Ugo De Giorgi, Cristina Masini, Franco Morelli, Maria Giuseppa Vitale, Teodoro Sava, Giuseppe Prati, Carmelinda Librici, Anna Paola Fraccon, Giuseppe Fornarini, Francesco Leonardi, Orazio Caffo
Journal: Journal of Clinical Oncology (2016)

e16081 Background: Pazopanib is a standard first line treatment for metastatic clear cell renal cell carcinoma (RCC). Very few data on its activity in non-clear cell RCC (nccRCC) are currently available in the literature. We retrospectively analyzed the efficacy and toxicity of Pazopanib in an Italian multicenter cohort of nccRCC patients. Methods: Records from nccRCC patients treated with first line Pazopanib were reviewed and collected. The response rate (RR), progression free survival (PFS), and overall survival (OS) were evaluated in this cohort. Univariate analysis was conducted to correlate clinicopathologic factors with outcome. Descriptive analyses of patients and diseases characteristics were also performed. Results: Between 2010 and 2015, 36 patients with nccRCC were treated with Pazopanib as first line therapy in 16 Italian centers. Median age was 65 years. 25% had chromophobe histology, 50% papillary, 22% unclassified and 3% had Xp11 translocation. Motzer and Heng risk were good in 22% and 22%, intermediate in 66% and 47% and poor in 11% and 22% of patients respectively. 75% had nephrectomy. 55% had performance status (PS) = 0, 28% PS = 1 and 17% PS = 2-3. 22% had a basal neutrophil to lymphocyte ratio (NLR) > 3. Dose reductions/interruptions of Pazopanib for toxicity were required in 47% of cases; G3-4 toxicity occurred in 33% of patients, G1-2 in 89%. 80% achieved a clinical benefit [partial response (28%) plus stable disease (52%)], while 14% had disease progression as best response. Median PFS (36% censored) and OS were 15.9 [95%CI 6.2-25.5] and 17.3 [95%CI 11.5-23.1] months, respectively. At the univariate analysis factors associated with OS were Motzer score (p = 0.005), Heng score (p = 0.002), PS (p < 0.0001) and N/L ratio (p = 0.027). Factors associated with PFS were Motzer score (p = 0.007), N/L ratio (p = 0.007) and PS (p < 0.0001). 42% of patients underwent second line therapy. Conclusions: In nccRCC patients, treatment with Pazopanib demonstrated to be effective and quite safe, despite dose reductions often required for toxicity.
The Mavericks
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell–mediated immunotherapy
Authors: Jonathan D. Silk, Ian F. Hermans, Uzi Gileadi, Tsung Wen Chong, Dawn Shepherd, Mariolina Salio, Bini Mathew, Richard R. Schmidt, Sarah Jane Lunt, Kaye J. Williams, Ian J. Stratford, Adrian L. Harris, Vincenzo Cerundolo
Journal: Journal of Clinical Investigation (2004)

Activation of invariant CD1d-dependent NK T cells (iNKT cells) in vivo through administration of the glycolipid ligand α-galactosylceramide (α-GalCer) or the sphingosine-truncated α-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and γ interferons that contribute to DC maturation. This process enhances T cell immunity to antigens presented by the DC. The adjuvant activity is further amplified if APCs are stimulated through Toll-like receptor 4, suggesting that iNKT cell signals can amplify maturation induced by microbial stimuli. The adjuvant activity of α-GalCer enhances both priming and boosting of CD8+ T cells to coadministered peptide or protein antigens, including a peptide encoding the clinically relevant, HLA-A2–restricted epitope of the human tumor antigen NY-ESO-1. Importantly, α-GalCer was used to induce CD8+ T cells to antigens delivered orally, despite the fact that this route of administration is normally associated with blunted responses. Only T cell responses induced in the presence of iNKT cell stimulation, whether by the i.v. or oral route, were capable of eradicating established tumors. Together these data highlight the therapeutic potential of iNKT cell ligands in vaccination strategies, particularly “heterologous prime-boost” strategies against tumors, and provide evidence that iNKT cell stimulation may be exploited in the development of oral vaccines.
Book Review Asthma and the General Practitioner . By James Adam, M.A., M.D., F.R.F.P.S.G., with a foreword by James Bridie, O. H. Mavor, M.D. 8°, cloth, 157 pp. Baltimore: Williams &amp; Wilkins Co., 1939. $2.00.
Journal: New England Journal of Medicine (1940)