tbuckley/cabot-search huggingface dataset:
A Small Molecule Inverse Agonist for the Human Thyroid-Stimulating Hormone Receptor
Authors: Susanne Neumann, Wenwei Huang, Elena Eliseeva, Steve Titus, Craig J. Thomas, Marvin C. Gershengorn
Journal: Endocrine Reviews (2010)

ABSTRACT Small molecule inverse agonists for the TSH receptor (TSHR) may be used as probes of the role of basal (or agonist-independent or constitutive) signaling and may have therapeutic potential as orally active drugs to inhibit basal signaling in patients with thyroid cancer and in some patients with hyperthyroidism. We describe the first small-molecule ligand [1, 2-(3-((2,6-dimethylphenoxy)methyl)-4-methoxyphenyl)-3-(furan-2-ylmethyl)-2,3-dihydroquinazolin-4(1H)-one] that exhibits inverse agonist properties at TSHR. 1 inhibits basal and TSH-stimulated signaling, measured as cAMP production, by TSHRs in HEK-EM 293 cells stably expressing wild-type TSHRs; the antagonism of TSH-mediated signaling is competitive. 1 also inhibits basal signaling by wild-type TSHRs, and four constitutively active mutants of TSHR expressed transiently in HEK-EM 293 cells. 1 was active under more physiologically relevant conditions in primary cultures of human thyrocytes expressing endogenous TSHRs where it inhibited basal levels of mRNA transcripts for thyroglobulin, thyroperoxidase, sodium iodide symporter, and TSHR. These data serve as proof of principle that small, drug-like molecules can inhibit basal signaling by TSHR. We suggest that this small molecule is a lead compound for the development of higher-potency inverse agonists that can be used as probes of TSHR biology with therapeutic potential.
DANGER FOR AFTER-DINNER SPEAKERS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Extranodal sinus histiocytosis with massive lymphadenopathy presenting as an intramedullary spinal cord tumor: A case report
Authors: Matthew P. Jones, M. Eugenia Rueda‐Pedraza
Journal: American Journal of Hematology (1997)

Involvement of the central nervous system by sinus histiocytosis with massive lymph-adenopathy (SHML) is rare. Less than 30 cases have been reported. To the best of our knowledge, we describe the first case of an intramedullary spinal cord lesion which occurred in a 34-year-old black male, causing paraplegia. Laboratory evaluation revealed anemia, increased erythrocyte sedimentation rate, and polyclonal gammopathy. Microscopic examination of the lesion revealed lymphocytes within the cytoplasm of the histiocytic cells, a phenomenon known as emperipolesis. Immunohistochemical stains showed the large eosinophilic histiocytic cells to be positive for S-100 protein and Kp1 antigen. Special stains for fungi and acid-fast organisms were negative. There was no evidence of clonality in the lymphocytic aggregates. Glial fibrillary acidic protein was negative in the lesion, although positive in the surrounding tissue. These features confirmed the diagnosis of extranodal SHML involving the intramedullary spinal cord. Am. J. Hematol. 54:253–257, 1997 © 1997 Wiley-Liss, Inc.
Alkyl mercury poisoning in humans. Report of an outbreak
Authors: P. E. Pierce
Journal: JAMA (1972)

Three members of a family of nine that ingested mercury-contaminated pork became ill with classic symptoms of methylmercury poisoning and rapidly progressed to coma or semicomatose states. Treatment with dimercaprol (BAL in Oil) and n-acetyl-d, I-penicillamine was not associated with significant immediate clinical improvement, although both drugs appeared to increase urinary excretion of mercury. All three patients improved considerably but still remain severely impaired. A case of congenital methylmercury poisoning also resulted from the outbreak. To our knowledge, this is the first known instance in the United States of methylmercury poisoning resulting from ingestion of mercury-contaminated meat.
International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Eastern and Central Europe
Authors: Alicja Dębska-Ślizień, Aminu K. Bello, David W. Johnson, Vivekanand Jha, David C.H. Harris, Adeera Levin, Marcello Tonelli, Syed Saad, Deenaz Zaidi, Mohamed A. Osman, Feng Ye, Maryam Khan, Meaghan Lunney, Ikechi G. Okpechi, Rumeyza Turan Kazancioglu
Journal: Kidney International Supplements (2021)
Cardiopulmonary Resuscitation
Authors: Charles L. Baird
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Guidelines for CPR and emergency cardiac care are nicely presented in the October 28, 1992, issue.<sup>1</sup>However, it is unfortunate that organized medicine has ignored the potential role of screening of the high-risk population. Rather than emphasis on the management of the emergency crisis, there should be consideration for early identification of silent ischemia and risk stratification so that appropriate therapy might avoid death or a myocardial infarction. It might be helpful to adopt the concept of the American Cancer Society, which promotes screening and the early detection of malignancies to engender broader options and lower costs.
Surgical Wire Welding
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Teenage Pregnancy
Authors: John W. Burnside
Journal: Annals of Internal Medicine (1991)

Letters1 June 1991Teenage PregnancyJohn W. Burnside, MDJohn W. Burnside, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-11-994_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Because the results of teenage pregnancy, either delivery or abortion, fall within the province of health care, it is generally assumed that teenage pregnancy must therefore be a disease. Bolstered by the recommendations of our government that a healthy society requires the reduction of the incidence of teenage pregnancy, we accept the challenge to fix the problem without commenting on either the necessity or sufficiency of our role. We have once again acquiesced to the medicalization of a social ill and are once again getting prepared to accept blame when we fail, as we inevitably will.Drs....Reference1. FieldingWilliams JC. Unintended pregnancy among teenagers: important roles for primary care providers. Ann Intern Med. 1991;114:599-601. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Texas Southwestern Medical School Dallas, TX 75235-9005 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCounseling youths about firearms 1 June 1991Volume 114, Issue 11Page: 994-995KeywordsFallsHealth carePregnancy Issue Published: 1 June 1991 PDF DownloadLoading ...
Abstract 1967: Nab-paclitaxel chemotherapy of breast tumors upregulates chemokines that increase chemotaxis of myeloid-lymphatic progenitors
Authors: Lisa D. Volk-Draper, Sophia Ran
Journal: Cancer Research (2019)

Abstract Introduction: Lymph node metastasis is the main prognostic indicator for poor survival of breast cancer patients. Metastasis is promoted by tumor-induced lymphangiogenesis mediated, in part, through recruitment of myeloid-derived lymphatic endothelial cell progenitors (M-LECP). We previously showed that differentiation of M-LECP is induced by activated Toll-like receptor-4 (TLR4). The goal of this study was to identify TLR4-induced chemokines produced by tumors alone or in response to nab-paclitaxel (nab-PXL) chemotherapy that enhance bone marrow (BM) differentiation and tumor recruitment of M-LECP. Methods: Profile of BM composition for lymphatic-like, myeloid and progenitor cells was assessed by flow cytometry in normal and tumor-bearing mice treated either with saline or nab-PXL. We used two TLR4 overexpressing tumor models: MDA-MB-231 and HCC1806-TLR4+. RT-qPCR was used to determine differences in expression of 130 cytokines in cultured tumor cells and tumors from mice treated either with saline or nab-PXL. Targets with &amp;gt;2-fold upregulation were analyzed for protein expression by ELISA. ELISA-validated cytokines were tested for their ability to induce migration of M-LECP. Results: Both MDA-MB-231 or HCC1806-TLR4+ tumors significantly increased the levels of differentiated M-LECP in the BM, and that was further enhanced by treatment with taxane chemotherapy. Expression of progenitor markers CD117, CD33, and Sca-1 was increased up to 7-fold in both tested tumor models, and further upregulated by nab-PXL treatment by additional 3 to 9-fold. Out of 23 cytokines measured in tumor lysates by ELISA, 40% were upregulated by nab-PXL. Migration assay showed that several of these cytokines increased chemotaxis of M-LECP with CXCL1 being the strongest. Neutralization of CXCL1 in the conditioned medium of nab-PXL-treated MDA-MB-231 cells inhibited migration of lymphatic progenitors by 75%. Conclusion: Taxane chemotherapy acting presumably as a ligand for TLR4 significantly expanded M-LECP population in the BM. Our analysis suggests that these lymphatic precursors can mobilize to tumors by chemokines such as CXCL1 that are highly upregulated in TLR4-positive tumor cells, particularly when activated by paclitaxel. These data suggest that CXCL1 plays an important role in recruiting myeloid-lymphatic progenitors to breast tumors, which, in turn, promotes lymphatic vessel formation and metastasis. Blocking this cytokine might have clinical utility for prevention of tumor mobilization of M-LECP, and by extension, breast cancer metastasis to lymph nodes. Citation Format: Lisa D. Volk-Draper, Sophia Ran. Nab-paclitaxel chemotherapy of breast tumors upregulates chemokines that increase chemotaxis of myeloid-lymphatic progenitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1967.
THE TUBERCULIN TEST.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology
Authors: Ulla-Angela Temann, Prabir Ray, Richard A. Flavell
Journal: Journal of Clinical Investigation (2002)

IL-9 is a pleiotropic cytokine with multiple functions on many cell types involved in the pathology of human asthma.The constitutive overexpression of IL-9 in the lungs of transgenic mice resulted in an asthma-like phenotype.To define the contribution of IL-9 to lung inflammation we generated transgenic mice in which lung-specific expression of the IL-9 transgene is inducible by doxycycline.Transgene induction resulted in lymphocytic and eosinophilic infiltration of the lung, airway epithelial cell hypertrophy with mucus production, and mast cell hyperplasia, similar to that seen in mice that constitutively expressed IL-9 in their lungs.Various cytokines, including IL-4, IL-5, and IL-13, were expressed in the lung in response to IL-9.Blockade of IL-4 or IL-5 following IL-9 induction reduced airway eosinophilia without affecting mucus production.In contrast, neutralization of IL-13 completely abolished both lung inflammation and mucus production.These findings suggest that pathologic changes in the lung require additional signals beyond IL-9, provided by IL-4, IL-5, and IL-13, to develop fully.
Correction for a Sentence in the Results Section
Authors: Charlotte Skovlund, Lina Mørch, Øjvind Lidegaard
Journal: JAMA Psychiatry (2017)

window before initiation of use (eTable 5 in the Supplement of our article 1 ).This analysis demonstrated similar increases as the analyses with all nonusers as reference.Second, the risk for antidepressant use in users of hormonal contraception was compared with users of combined oral contraceptive with levonorgestrel (ethinykestradiol, 30-40 ug) (eTable 3 in the Supplement of our article 1 ).In this analysis, the relative risk varied between different types of hormonal contraception according to dose, progestin type, and route of administration in a pattern that was consistent with the potential biological mechanisms underlying the association.Finally, Figure 2 in our article 1 demonstrated that the risk of both use of antidepressants and of getting a depression diagnosis increased rapidly after commencing use of hormonal contraception, which is difficult to explain if it should be characteristics in users of hormonal contraception rather than the use in itself that explain the increased risk for depression with hormonal contraceptive use.
TUBERCULOSIS OF THE STOMACH.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Virus-like structures in lupus erythematosus.
Journal: BMJ (1970)

MEDICBJORNAL 643than for those who had had normal births.It seems fair to say that the question whether salicylates in therapeutic doses cause human malformations has not yet been answered, and the problem is unlikely to be solved except by a large-scale prospective study.The College of General Practitioners carried out a pilot survey of this type in 1963, but though more than 1,000 pregnancies were followed up, and though aspirin was the medicine most frequently taken in early pregnancy, the survey was not large enough to give a decisive result.8Richards considers that an adequate inquiry would necessitate the follow-up of at least 10,000 pregnancies.A prospective survey of this magnitude, organized by the Royal College of General Practitioners is, in fact, nearing completion, and its results will be keenly awaited by all who are interested in the problem of con- genital malformations.Meanwhile it would seem prudent to advise against heavy doses of salicylates during pregnancy, but not to ban their use completely.Even if aspirin is shown eventually to be a human teratogen, it seems unlikely that it will prove to be a very potent one.
Real-world experience from tenofovir alafenamide use in chronic hepatitis B: an Hellenic multicenter real-life clinical study (HERACLIS-TAF)
Authors: George Papatheodoridis, Konstantinos Mimidis, Spilios Manolakopoulos, Nikolaos Gatselis, Ioannis Goulis, ANDREAS Kapatais, Emmanouil Manesis, Themistoklis Vasileiadis, Christos Triantos, Demetrious N. Samonakis, Vasilis Sevastianos, Stylianos Karapatanis, Ioannis Elefsiniotis, Melanie Deutsch, Theodora Mylopoulou, Margarita Papatheodoridi, Hariklia Kranidioti, Polyxeni Agorastou, Theofanie Karaoulani, Anastasia Kyriazidou, Konstanitnos Zisimopoulos, George Dalekos
Journal: Journal of Hepatology (2020)
What If Americans Ate Less Fat?
Authors: John C. Bailar
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Browner et al<sup>1</sup>concluded that an average reduction in fat intake from 37% of calories to 30% would add no more than 3 to 4 months to life expectancy in the United States. This conclusion is far more uncertain than would be apparent to the nonspecialist. The authors' elaborate mathematical model used data from many different sources. The model has not been validated; each of the data sources is subject to uncertainty, and the errors and approximations may interact in unexpected ways. The following are some examples. Browner et al considered only the direct effects of reducing fat intake as such. Other benefits, such as weight loss and increased intake of vegetables and fruits, were omitted. They limited their conclusions to coronary heart disease (CHD) and certain cancers; they ignored other health effects, positive or negative, such as any adverse effects of reducing serum cholesterol levels
Some Aspects of DEHP and Its Action on Lipid Metabolism
Authors: Michael S. Stein, Priscilla I. Caasi, Padmanabhan P. Nair
Journal: Environmental Health Perspectives (1973)

In 1967, Nazir et al. (1,2) reported the specific localization of di-2-ethylhexyl phthalate (DEHP) in bovine heart muscle mitochondria.This led us to investigate the action of dietary DEHP in a number of selected tissues.Preliminary, unpublished studies have indi- cated that adipose tissue and total body weights were affected by the addition of DEHP to the diet.The purpose of this study was to determine whether oral DEHP administration affects lipid or DEHP concentra- tions in a select number of organs.Another objective of this work was to determine whether tissue DEHP and lipid levels were affected by removal of fat from the normal diet.The heart, liver, and epididymal fat pad were used for experimental determinations.
A state plans for its future in medical education
Authors: J. D. Porterfield
Journal: JAMA (1965)

There are so many dimensions to be considered in medical education and in its future form, substance, and balance that it would be difficult merely to enumerate them in the limits of a single presentation. It would also be in great part redundant in the context of the program of the 61st Annual Congress on Medical Education, for older heads and wiser have expounded before and will again on the dynamic character of medical education. Suffice it to say, in preface, that we are not at the crossroads, a favorite cliché of those viewing the contemporary scene. Rather we are, and happily so, in a relatively continuous state of flux as we attempt to remain contemporary in the face of shifting needs, growing volume of knowledge, improvement in teaching methodology, and the everplaguing increase in costs. In this presentation I should like to concentrate for the most part on the
STATE MEDICINE.
Authors: Joshua M. Addeman
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal