tbuckley/cabot-search huggingface dataset:
Abstract 703: HIF-1α Dependent Expression of iNOS in Bone Marrow Stem Cells Mediates Protection of Cardiomyocytes against Ischemia
Authors: Ying Dai, Muhammad Ashraf, Yigang Wang, Meifeng Xu
Journal: Circulation (2007)

We hypothesized that inducible nitric oxide synthase (iNOS) upregulated in bone marrow stem cells (BMSCs) protect ischemic cardiomyocytes via hypoxia inducible factor-1α (HIF-1α) pathway. Methods: Isolated BMSCs were exposed to hypoxia for 24 hours. The level of HIF-1α protein and its activated form were measured by ELISA. The expression of iNOS and HIF-1α were analyzed by quantitative PCR and cellular localization was determined by immunohistochemistry. Cardiomyocytes in co-culture with BMSCs were subjected to hypoxia and H 2 O 2 (200 μmol). LDH release, DNA fragmentation and annexin-V positive cells were used as injury markers. Results : HIF-1α protein and its activated form were markedly increased (Fig. A, B ) and translocated to the nucleus or peri-nuclear area of BMSCs subjected to hypoxia, in parallel with increased expression of HIF-1α target gene iNOS, which was blocked by pretreating cells with neutralizing HIF-1α antibody (Fig. C ). Co-culture of cardiomyocytes with BMSCs not only prevented and reduced cardiomyocyte apoptosis induced by hypoxia and H 2 O 2 but also significantly reduced LDH release from cardiomyocytes (Fig. D–G ). The cardiac protection by BMSC was abolished by neutralizing HIF-1α antibodies, and by the selective iNOS inhibitor, 1400W (10 mg/L) as well as a potent competitive inhibitor of NOS, L-NAME (200 μmol/L). However, no effects of neutralizing HIF-1α antibody, L-NAME or 1400W on cardiomyocytes alone were seen. SNAP (300 μmol/L), a NO donor had no synergistic effect on the cardioprotective effect of BMSC. Conclusion: iNOS upregulated in bone marrow stem cells by hypoxia protects cardiomyocytes against ischemic injury via activating HIF-1α.
Therapeutics, Materia Medica and Pharmacy: The Special Therapeutics of Diseases and Symptoms, the Physiological and Therapeutical Actions of Drugs, the Modern Materia Medica, Official and Practical Pharmacy, Prescription Writing, and Antidotal and Antagonistic Treatment of Poisoning.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Narrative Medicine
Authors: Rita Charon
Journal: Annals of Internal Medicine (2001)

Letters20 November 2001Narrative MedicineRita Charon, MD, PhDRita Charon, MD, PhDCollege of Physicians and Surgeons of Columbia University; New York, NY 10032 (Charon)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-10-200111200-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I appreciate Dr. Poses's voicing concerns about the tensions between knowledge and uncertainty in medical practice. He argues, in effect, that the benefits of realizing the limits of certainty in our science are not worth the risks of upending positivism. I disagree. Perhaps our disagreements—which have been enacted elsewhere—are differences in framing. When I call sickness and doctoring narrative acts, I include within my frame not only the physical, pathophysiologic, and "trackable" events in a body and the pharmacologic and surgical interventions performed in response, but all the personal, emotional, relational, and ontological sequelae of failing health. Such ... Author, Article, and Disclosure InformationAffiliations: College of Physicians and Surgeons of Columbia University; New York, NY 10032 (Charon) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNarrative Medicine: Form, Function, and Ethics Rita Charon Narrative Medicine Roy M. Poses Metrics Cited ByNarrative methods for assessing "quality of life" in hand transplantation: five case studies with bioethical commentary 20 November 2001Volume 135, Issue 10Page: 930KeywordsAnxietyEmotionsForecastingHeart diseasesPerceptionScientists ePublished: 20 November 2001 Issue Published: 20 November 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Mind and Health.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Distant Healing
Authors: Kevin Courcey
Journal: Annals of Internal Medicine (2001)

Letters20 March 2001Distant HealingKevin Courcey, RNKevin Courcey, RNSacred Heart Hospital; Eugene, OR 97405 (Courcey)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-6-200103200-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Astin and colleagues' literature review on distant healing (1) was disappointing. While the authors admit that methodologic limitations in the research they reviewed “make it difficult to draw definitive conclusions about the efficacy of distant healing,” they assert that because 57% (n = 13) of these flawed studies showed some positive response to at least one measured variable, the interventions must warrant further study. The studies they reviewed, however, do not support such a conclusion. Only two of the five reviewed studies on prayer claimed positive results that reached significance. Harris and colleagues' study measured 33 different ...Reference1. Astin JA, Harkness E, Ernst E. The efficacy of “distant healing”: a systematic review of randomized trials. Ann Intern Med. 2000;132:903-10. [PMID: 0010836918] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Sacred Heart Hospital; Eugene, OR 97405 (Courcey) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Efficacy of “Distant Healing” John A. Astin , Elaine Harkness , and Edzard Ernst Distant Healing Ted J. Kaptchuk Distant Healing John Astin , Elaine Harkness , and Edzard Ernst Metrics Cited byIntercessory prayer and healing prayer 20 March 2001Volume 134, Issue 6Page: 532KeywordsAnxietyCardiac care unitPacemakersResearch fundingTouch ePublished: 20 March 2001 Issue Published: 20 March 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The prostate, ventilation, and anesthesia
Authors: A. H. Giesecke
Journal: JAMA (1968)

In an aged patient with emphysema, respiratory complications might be expected to develop following perineal prostatectomy under spinal anesthesia in the exaggerated lithotomy (Young's) position. Complications have failed to occur at the expected rate, prompting a study of ventilation in the exaggerated lithotomy position. Nine control subjects demonstrated reductions in timed forced vital capacity (FVC) and forced expiratory volume (FEV 0.5 second) similar to those previously reported for healthy volunteers in the lithotomy position. Eighteen urological patients with pulmonary disease manifest by reduced FVC and FEV 0.5 second were studied before and during spinal anesthesia. They had no change in the FVC but an improved FEV 0.5 second in the exaggerated lithotomy position. The weight of the viscera and thighs probably acts to improve the end-exhalational position of the diaphragm and adds force to the maximum expiratory effort.
Diet in Health and Disease.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Outmoded barbiturates.
Journal: BMJ (1974)

positive results, whereas negative skin tests were obtained again with Solu-Medrone and Solu-Cortef and also with methylprednisolone sodium succinate, methylprednisolone sodium acetate, hydrocortisone sodium succinate, prednisolone, prednisone, triamcinolone, dexamethasone, cortisone acetate, and the diluent solution.Passive transfer of the positive reactions were negative on three recipients, though the patient's positive skin test to Bermuda grass was passively transferable to each of the recipients.Serial measurements during two intravenous challenges which provoked anaphylaxis showed no significant change in six components ofthe complement system or fibrinogen.The interesting inconsistency between the results of the intravenous challenges and the skin tests is that the succinate salts of the steroid produced symptoms on challenge but only methylprednisolone or hydrocortisone alone gave positive skin tests.Mendelson et al. suggest that small structural changes in the molecule produced by succinylation or acetylation may have been responsible for the negative skin tests.
Enhanced expression of B7-1, B7-2, and intercellular adhesion molecule 1 in sinusoidal endothelial cells by warm ischemia/reperfusion injury in rat liver
Authors: N KOJIMA, M SATO, A SUZUKI, T SATO, S SATOH, T KATO, H SENOO
Journal: Hepatology (2001)

To elucidate a role of costimulatory molecule and cell adhesion molecule in hepatic ischemia/reperfusion injury, we examined an alteration in B7-1 (CD80), B7-2 (CD86), and intercellular adhesion molecule 1 (ICAM-1; CD54) expression in the rat liver after warm ischemia/reperfusion injury. To induce hepatic warm ischemia in a rat model, both portal vein and hepatic artery entering the left-lateral and median lobes were occluded by clamping for 30 minutes or 60 minutes, and then reperfused for 24 hours. B7-1, B7-2, and ICAM-1 expressions in the liver were analyzed by immunofluorescence staining and real-time reverse transcription polymerase chain reaction (RT-PCR). Although B7-1 and B7-2 expressions were at very low levels in the liver tissues from normal or sham-operated control rats, both B7-1 and B7-2 expressions were enhanced at protein and messenger RNA (mRNA) levels in the affected, left lobes after warm ischemia/reperfusion. ICAM-1 protein and mRNA were constitutively expressed in the liver of normal and sham-operated control rats, and further up-regulated after warm ischemia/reperfusion. Localization of increased B7-1, B7-2, and ICAM-1 proteins, as well as von Willebrand factor as a marker protein for endothelial cells, was confined by immunofluorescence staining to sinusoidal endothelial cells in hepatic lobules. Data from quantitative real-time RT-PCR analysis revealed that B7-1 and B7-2 mRNA levels were elevated in hepatic lobes after warm ischemia/reperfusion (5.13- and 52.9-fold increase, respectively), whereas ICAM-1 mRNA expression was rather constitutive but further enhanced by warm ischemia/reperfusion (4.24-fold increase). These results suggest that hepatic sinusoidal endothelial cells play a pivotal role as antigen-presenting cells by expressing B7-1 and B7-2 in warm hepatic ischemia/reperfusion injury, and that B7-1 and/or B7-2 might be the primary target to prevent early rejection and inflammatory reactions after hepatic ischemia/reperfusion injury associated with liver transplantation.
Occupational and environmental medicine
Authors: A. L. Frank
Journal: JAMA (1992)

The past year was remarkable for two occurrences in the field of occupational and environmental medicine. The first is the role that preventive medicine, in its occupational and environmental aspects, played in protecting the health of US forces participating in Operation Desert Storm in the Middle East. Because of preventive actions taken in relation to the ambient working environment, and for the important issues of supplying necessary water and controlling infectious diseases, the half million troops participating in Operation Desert Storm experienced a remarkably low incidence of preventable illness traceable to infectious causes or dehydration. The insistence on proper fluid intake, coupled with infection control at the "worksite," led to a low casualty rate among troops. A major source of morbidity and mortality involved traditional workplace problems such as injuries, including motor vehicle accidents. While clearly nontraditional, an outstanding contribution was made to the overall effort by those who had
The Cover
Authors: Michael W. Vannier
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening Tests for Pulmonary Function Abnormality
Authors: Albert Miller
Journal: Environmental Health Perspectives (1975)

Simple tests based on a voluntary forced expiration can detect pulmonary impairment of occupational or environmental origin earlier than can be done using clinical or radiographic examination. These tests are easily performed and repeated, require little time and can be readily set up in the field. Flow impairment ("obstructive") has conventionally been measured by the forced expiratory volume--1 sec (FEV1); earlier changes, in the small airways are more likely to be detected by the maximal mid-expiratory flow (MMF) and the maximum expiratory flow-volume (MEFV) curve at low lung volumes. Volume impairment ("restrictive") is detected by the forced vital capacity (FVC) from which the preceding measurements are made.
Erratum: “Physiologically Based Pharmacokinetic Modeling of Persistent Organic Pollutants for Lifetime Exposure Assessment: A New Tool in Breast Cancer Epidemiologic Studies”
Journal: Environmental Health Perspectives (2013)

In the legend for Figure 3, the descriptions for D and E were inverted.The corrected figure legend is as follows:Figure 3. Toxicokinetic profiles for PCB-153, PCB-180, and HCB blood concentration for (A) normal body weight history and 10 ng/kg/day exposure to each of these chemicals for a woman who was not breast-fed in childhood (blue line) or breast-fed for 6 months (black line); (B) normal weight (gray line), weight loss (black line), or overweight (blue line) profiles and 10 ng/kg/day exposure to each of these chemicals for women who were breast-fed for 6 months in childhood; (C) normal body weight history and 10 ng/kg/day exposure to each of these chemicals for a woman who was breast-fed for 6 months in childhood and had a pregnancy at 30 years of age followed by no lactation (blue line) or a 12-month lactation period (black line); (D) normal body weight history and 10 ng/kg/ day exposure to each of these chemicals for a woman who had a pregnancy at 35 years of age followed by a 6-month lactation period (blue line) or a 12-month lactation period (black line); (E) normal body weight history and 10 ng/kg/day exposure to each of these chemi cals for a woman who was breast-fed for 6 months in childhood and had a pregnancy followed by a 12-month lactation period at 20 years of age (blue line) or 35 years of age (black line); (F) normal body weight history for a woman who was exposed to 10 ng/kg/day of each of the three chemicals and had no pregnancy (black line) or was breast-fed for 6 months in childhood, was exposed to 18.7 ng/kg/day PCB-153, 13.8 ng/kg/day PCB-180, 11.6 ng/kg/day HCB, and who had two pregnancies at 35 and 40 years of age followed by 12-month lactation periods (blue line).
Erratum to: Prognostic factors and historical trends in the epidemiology of candidemia in critically ill patients: an analysis of five multicenter studies sequentially conducted over a 9-year period
Authors: Arnaldo L. Colombo, Thais Guimarães, Teresa Sukienik, Alessandro C. Pasqualotto, Ricardo Andreotti, Flavio Queiroz-Telles, Simone A. Nouér, Marcio Nucci
Journal: Intensive Care Medicine (2014)
Pace, Pace
Authors: Naomi G. Smith
Journal: JAMA (1991)

She hadn't the entourage at her deathbed that my father had had. Only me, and I wasn't there at the end. Finally left, stopping on the way home to buy a sandwich, barely sitting down in front of the TV to eat it before the phone rang. "I'm sorry, your mother is dead," the nurse said. Pause. "I think she waited until you'd left." I felt a vast, encompassing wave of relief. It was tinged with regret that I hadn't stayed just a little longer, but mostly there was relief. The whole thing had gone on for so long and I was so tired. Sometimes I felt that maybe I was as tired of it as she, tired of watching her battered by the strokes that nibbled at her faculties, destroying a muscle here, a nerve center there, blurring her speech, the cruel little stroke that sliced her sight, leaving
Electronic Library
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heat shock protein 60 enhances CD4+CD25+ regulatory T cell function via innate TLR2 signaling
Authors: Alexandra Zanin-Zhorov, Liora Cahalon, Guy Tal, Raanan Margalit, Ofer Lider, Irun R. Cohen
Journal: Journal of Clinical Investigation (2018)

During the assembly of Figure 4A, an incorrect image was inadvertently used for the SVZ section for the whole-body XRT sample.The correct figure panel is below.
Clinical features of symptomatic non-B non-C non-Alcoholic chronic liver disease in Japan . Department of Gastroenterology, Tenri Hospital, Nara, Japan
Journal: Hepatology (1995)

In order to study the prevalence of hepatitis E virus (HEV) infection in developed countries, IgG and IgM anti-HEV were determined in serum samples from 382 patients with acute viral hepatitis (244 hepatitis A, 48 hepatitis B and/or D, and 90 non-A, non-B, non-C hepatitis), 76 healthy subjects, 55 hemophiliacs and 50 patients on hemodialysis. IgG anti-HEV antibodies were detected and confirmed by a synthetic peptide-based EIA in 5 (5.6%) non-A, non-B, non-C acute hepatitis, in 3 (6.5%) B and D acute hepatitis, in 10 (4%) acute A hepatitis, in 3 (5.5%) of 54 healthy adults in none of the hemophiliacs and in 3 (6%) patients on hemodialysis. IgM anti-HEV antibodies were only detected in two cases of acute hepatitis B and/or D. Analysis of serial serum samples demonstrated IgG anti-HEV seroconversion in 3 of the 18 confirmed cases; one of them was also positive for IgM anti-HEV. All 3 acute anti-HEV-positive hepatitis cases occurred in adults, were community-acquired (two of them were intravenous drug addicts) and had a self-limited course. These results demonstrate that HEV is a minor cause of acute hepatitis in Spain. A similar low rate of IgG anti-HEV antibodies was detected in patients with different diseases, suggesting that HEV has a very low epidemiological impact. An apparent association of HEV infection with hepatitis B and D suggests a possible parenteral transmission of a mainly enteral pathogen.