tbuckley/cabot-search huggingface dataset:
Errata
Journal: BMJ (1888)

MER RRT7'1Tff MRDICAL JOURVAL (Oct.27, 1888 is the case frequently wlhen thte limbs are still rigid; flacciditv of muscles and passive breathing are fAr hetter guides.I lave alwavs found it.a great help to free breathing to compress tihe lower jaw against, tle tipper by the tips of thle lingers placedl on eithie-r sile ; this, iv stiuptortilln the tonigute.prevents it fallinig hwk or doubling upon itself as it were---one of tite ehliief danigers to be avoi(dedi during administration.Moreover.one of the tintgers retinig qtietly 11W11 the fa-ial artery as it crosses tile l(ower' jatw to tlhe angle of tile nmlouthl at the antterior intletr: *f tne inacaster, will at 1ite samt time give the state of tie pUIlse; tihis pla;itl Cn e easily adotpted with the ordiniary chloroform in- htler or Clover's aptpaxrattus for ether, the preistire of thie tliulinh leing quite stufricienit to keel tine mouthpiece in lposition.Tue latter.aifter the tirst few himiialations, should le kept evenly andt (cuseh1 applied.but particuilarly in thle case of Clover's apparattius it s-houl(l is' removed fronm the face about everv fifthi inspiration; by this means itiuesthesia may be kept up for a lengthened peri(il, in most eases withi little or no einil:irrassment to breathing.I lave Jiarti('ularly notice(l.in cases where dlifletilt v lhas arisen, that when chloro- form. is the agent intenise pallor if comnt eii;;oMe wit-ii llileness of lips is atnl early symptom; andi withi et ler clongest ionllan turgidtity,especially abont tlie neck atn(d loles of tine ears.Tue state of thie pupil is also a gtuide; ill ex- t reme dilatation the antestiet i siouildi be wit hiheil, part icilltrly cliloroform.Tongie.-forcees should always le quiite lhtaily.In thte se(oi(I place.wshell alarining s'ymnptonils (oarise.the lirst thliling 'iotnl(t be to dlraw tlie patlenit's lhead well (iver thie table so( that it qniite aliligs dlowni.the tOTigiue seizedl an(d drawn well foranidto oie corier of tlne niotil whlile artilelal respiration is eniuployeil.Quite as good as injection,s of etier is an enema of lot brandv- and-%sater, abouit, x,lv.It these iniastires doIot.quickly restore, the elhest shouldlie vigiirously flappetl witht the ornier of a towel diptpd in cold water; thlis is far better thtin lhot flaninels ; it mustt he uise(d with some force.I call to nniin(l two strikinig cases,.where t ief subtojects were given lilt fnr ileaii, when thiis means acted in tlc mnost.marvellous muannmner, eomlising a loug spa'miodi(i inspi- ration, an(l the patients to start lip fromi t lie talile.Aniothlier plan fromt which I I1m;7e seem exellent.results is the inversionl of t lie b,Noy liead(1 (lowntwartds otn thleb table.I miu11st niot omit to minenitioin, 515s(, the grttet go(xl I have experiencetle flrmtiii the inhalation (of nlitrite of aitmyl cap- Stiles.Above all eacih minasure should lbe adoptedi withi d1ecision an(l promptitude.for at such titeils minany are aplt to lose their hiealIs, an(il somnetinies the patient also.
Pathogenic role of hepatitis B virus in hepatitis B surface antigen-negative decompensated cirrhosis
Authors: H CHUNG
Journal: Hepatology (1995)

This study was conducted to determine the rate of detection of serum hepatitis B virus (HBV) DNA in hepatitis B surface antigen (HBsAg)-negative decompensated cirrhotic patients who had hepatitis B core and/ or surface antibodies (anti-HBc and/or anti-HBs), and to compare the outcome of HBsAg-positive cirrhotic patients who did or did not clear HBsAg during follow-up. Six (5%) of 121 HBsAg-positive cirrhotic patients lost HBsAg after 0.2 to 17.1 years (mean, 9.1 ± 6.2 yr) of follow-up. The cumulative rates of loss of HBsAg at 1, 5, 10, and 15 years were, respectively, 1.3%, 1.3%, 7.4%, and 44.5%. Compared with the patients who remained HBsAg-positive, those who lost HBsAg had milder disease at presentation and significantly longer survival. Of the patients who lost HBsAg, 83% had improvement in liver function after the loss of HBsAg, and all were alive at the time of writing (0.8 to 5.7 years after loss of HBsAg), whereas 27% of those who remained HBsAg-positive had died and 29% had deterioration in liver function. The rate of detection of serum HBV DNA by polymerase chain reaction (PCR) assay was higher in HBsAg-positive cirrhotic patients who lost HBsAg: 67% versus cirrhotic patients who had no previous history of chronic HBV infection; 16% (cryptogenic) and 29% (hepatitis C virus and/or alcoholinduced liver disease). In summary, we found that using PCR, serum HBV DNA can be detected in 28% of HBsAgnegative cirrhotic patients who were studied, but the pathogenic significance of such small amounts of virus is not clear. Liver function can improve and survival can be prolonged in HBsAg positive decompensated cirrhotic patients who subsequently lost HBsAg.
Medicolegal Rounds
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
(23) Monilethrix
Authors: J. Dawson, A.M.T. Kelly
Journal: British Journal of Dermatology (1984)

Journal Article (23) Monilethrix Get access J. Dawson, J. Dawson Belfast City Hospital, Belfast Search for other works by this author on: Oxford Academic Google Scholar A.M.T. Kelly A.M.T. Kelly Belfast City Hospital, Belfast Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Page 68, https://doi.org/10.1111/j.1365-2133.1984.tb05293.x Published: 01 July 1984
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1972)

COMMITTEE ON MATERNAL WELFAREEclampsiaA 21-year-old primigravida was first seen at 12 weeks, having had hospital care for nephritis in childhood and having declined advice to consult an internist at 19 years of age for hypertension. At present, the vital signs, including blood pressure, were normal and so was urinalysis.At 18 weeks the blood pressure was 150/100, she had gained 1.8 kg, and there was a trace of proteinuria. The patient was now seen at two-week intervals. By 26 weeks the blood pressure was 170/110, and although the urine was not examined, the blood urea nitrogen and creatinine . . .
Carcinoid tumors of the gastrointestinal tract
Authors: F. A. Weidner
Journal: JAMA (1981)

CARCINOID tumors have attracted much attention because of their endocrine activity and the unique symptoms that may result from their existence. Once considered benign, their malignant potential is now well appreciated.<sup>1</sup>Radiologically, these relatively uncommon tumors can present a variety of appearances that are a reflection of both tumor growth and secondary tissue reaction. Preoperative diagnosis is notoriously difficult and requires a synthesis of clinical, laboratory, and radiological data. The incidence of carcinoid tumors based on autopsy studies ranges from 0.08% to 1.36%. They are derived from cellular elements originating in the primitive neural-crest ectoderm. These cells migrate to several areas and belong to a family sharing the features of amine content, precursor uptake, and decarboxylation (APUD).<sup>2</sup>Therefore, these carcinoid APUD neoplasms can occur in the gastrointestinal (GI) tract, GI derivatives (pancreatobiliary tract), and primordial GI derivatives (lungs, genitourinary tract, thymus). A consistently positive relationship between carcinoid neoplasms
Diagnostic errors in the evaluation of behavioral disorders
Authors: R. S. Hoffman
Journal: JAMA (1982)

In 215 patients referred to a specialized medical-psychiatric inpatient unit, thorough neuropsychiatric evaluation resulted in a therapeutically important alteration of the referring diagnosis in 41%. Of patients referred with a tentative diagnosis of dementia, 63% were found to have treatable conditions. Increased educational efforts and use of neuropsychiatric consultation services are suggested to minimize diagnostic errors in medical practice. (<i>JAMA</i>1982;248:964-967)
FRANCE
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cruise Ship Illness Declines
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circuit
Authors: Valerie Wohlfeld
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 152: Urotensin-II Activates Rac-1 And ROS Production In Pulmonary Artery Smooth Muscle Cells Involving GPR14 And Gα <sub>I3</sub> Proteins
Authors: Talija Djordjevic, Nicola Schaefer, Michael Weitnauer, John Hess, Agnes Görlach
Journal: Circulation (2007)

Human urotensin II (hU-II) has recently been described as a potent vasoactive peptide associated with remodelling processes within the vasculature, thus contributing to various cardiovascular diseases including pulmonary hypertension. hU-II acts via the G-protein coupled receptor GPR14. However, the mechanisms mediating GPR14 signalling remain unclear. ROS have been shown to act as signalling molecules in vascular cells, and NADPH oxidases which are activated by Rac-1, are important sources of ROS generation. Therefore, we investigated whether hU-II and GPR14 can activate Rac-1 and NADPH oxidase-mediated ROS production in pulmonary artery smooth muscle cells (PASMC). Urotensin-II activated Rac-1 within 15 seconds and this response was abolished by treatment of PASMC with the GPR14 antagonist urantide. In line, urotensin-II induced a rapid increase in ROS levels within 5 minutes of application, which was prevented by urantide or transfection of a dominant-negative mutant of Rac-1 (RacT17N). Furthermore, in cells overexpressing GPR14 or constitutively active Rac-1 (RacG12V), hU-II-stimulated ROS generation was further enhanced. Interestingly, in the presence of Pertussis toxin, hU-II-induced Rac-1 activation and ROS generation were abolished, indicating coupling of GPR14 to Gα i proteins. Indeed, transfection of dominant-negative G α i3 completely diminished hU-II-stimulated ROS generation in PASMC. Similar effects were observed upon depletion of the NADPH oxidase subunit NOX4. Furthermore, hU-II, RacG12V and NOX4 stimulated proliferation of PASMC, whereas antioxidants, RacT17N or NOX4 depletion had opposite effects.These results show that hU-II is a potent activator of Rac-1 leading to rapid activation of NADPH oxidase and ROS generation involving GPR14 and Gα i3 proteins, and subsequent stimulation of PASMC proliferation. Thus, activation of NADPH oxidase by GPR14 and Rac-1 provides a novel mechanism how hU-II can promote vascular remodelling processes and may provide a novel therapeutic target for pulmonary vasculopathies associated with pulmonary hypertension.
Competitive Examinations.
Authors: Henry F. Lewis
Journal: JAMA (1899)

Chicago, May 13, 1899. <h3>To the Editor:</h3> —The letter from Dr. Bayard Holmes (see April 29, p. 927) and one in theJournalof May 13 (p. 1043), from "R." of Cincinnati, concerning the written examinations for internes of the Cook County Hospital, present a subject of interest to graduates and well-wishers of the institution. It is perfectly obvious that a purely written test of an applicant's knowledge of medical science and practice can never be a good test. As Dr. Holmes says, this method of conducting the hospital examination has resulted in causing the promising men in the medical schools of Chicago to spend the last year of their course in cramming with word knowledge and to devoting their time to quizzes, to the neglect of the clinic and other legitimate work of the year; this too, with the approval of the faculties. The men who carry off the
PARIS
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Educational Programs in US Medical Schools
Authors: Harry S. Jonas
Journal: JAMA (1993)

IN THIS section 2 years ago, we described a process of "curricular ferment" that was occurring in US medical schools.<sup>1</sup>This characterization was supported by evidence of comprehensive educational change at a number of medical schools, in part stimulated by an influx of funding from private foundations. On balance, the outlook for medical education at that time was essentially positive. While medical education was being influenced by internal and external pressures, it appeared to be in control of its own destiny. During the past year, a less optimistic scenario has emerged as the external pressures have intensified. Health system reform, a phrase that stands for fundamental changes in the organization and financing of health care, has been a major topic of discussion among policymakers and the media. Although it is not clear at this writing what form health system reform will eventually take, all the options that have been
Abstract 16903: Prognostic Value of Combined CT Angiography and Myocardial Perfusion Imaging vs. Invasive Coronary Angiography and Nuclear Stress Perfusion Imaging for Predicting Major Adverse Cardiovascular Events - The CORE320 Multicenter Study
Authors: Marcus Y Chen, Carlos E Rochitte, Armin Arbab-Zadeh, Marc Dewey, Richard T George, Julie M Miller, Hiroyuki Niinuma, Kunihiro Yoshioka, Kakuya Kitagawa, Shiro Nakamori, Roger Laham, Andrea L Vavere, Rodrigo J Cerci, Vishal C Mehra, Cesar Nomura, Klaus F Kofoed, Masahiro Jinzaki, Sachio Kuribayashi, Albert de Roos, Michael Laule, Swee Yaw Tan, John Hoe, Narinder Paul, Frank J Rybicki, Jeffery A Brinker, Andrew E Arai, Christopher Cox, Melvin E Clouse, Marcelo F Di Carli, Joao A Lima
Journal: Circulation (2015)

Background: Noninvasive risk stratification in patients with suspected coronary artery disease (CAD) is critical for implementing appropriate strategies to prevent major adverse events (MACE). We aim to compare the survival and accuracy of combined CT angiography (CTA) and CT myocardial stress perfusion imaging (CTP) with combined invasive coronary angiography (ICA) and stress SPECT myocardial perfusion imaging for predicting MACE in patients with suspected CAD. Methods: The CORE320 prospective multicenter study enrolled 381 patients, between 45-85 years of age, who were clinically referred for ICA. Overall, 379 participants had all imaging including coronary CTA, adenosine stress CTP, SPECT and ICA plus complete 2 year follow-up data. An independent panel adjudicated all adverse events. MACE was defined as late revascularization (beyond 30 days of index ICA), myocardial infarction, cardiac death, hospitalization for chest pain or congestive heart failure, and arrhythmia. Kaplan-Meier survival analysis was performed and area under the receiving operating characteristic curve (AUC) was used to determine test accuracy. Results: MACE (45 late revascularizations, 5 myocardial infarctions, 1 cardiac death, 8 hospitalizations for chest pain or congestive heart failure, and 1 arrhythmia) occurred in 51 of 379 patients. The 2 year MACE event free rate for combined CTA/CTP findings was 95% (-) vs. 82% (+) (Figure, p&lt;0.001) and similar to combined ICA/SPECT (p&lt;0.001). Event rates for CTA/CTP vs. ICA/SPECT for either positive or negative results were not significantly different (p=0.126 and p=0.284, respectively). The overall AUC of combined CTA and CTP vs. combined ICA and SPECT for identifying MACE at 2 years was also similar: 68 (95%CI: 62-75) vs. 71 (95%CI: 65-79), respectively, p=0.357. Conclusion: Combined CTA and CTP yields similar prediction of 2 year MACE (especially revascularization) and diagnostic accuracy compared to standard ICA and SPECT.
Miscellanea edica
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute rheumatic fever in children. Incidence in a borough of New York City
Authors: K. D. Brownell
Journal: JAMA (1973)

A total of 347 school children in Manhattan had verified attacks of rheumatic fever in 1963, 1964, and 1965. The average annual incidence in children aged five through 14 years was 61/100,000(49/100,000 first attacks and 12/100,000 recurrences). Incidence in the lowest income area was more than three times that in a high and middle income area. Although initial attacks of rheumatic fever continue to occur in appreciable numbers, the prescription of prophylactic medication has reduced the incidence of recurrences. However, almost half of those who had recurrences developed heart disease. Primary and secondary prevention programs must be intensified, especially in low-income urban areas, if rheumatic fever and rheumatic heart disease are to become diseases of the past.