tbuckley/cabot-search huggingface dataset:
OC-023 Extracorporeal liver support using UCL-arsenel reduces inflammation, improves haemodynamic function and increase survival time in a porcine paracetamol-induced acute liver failure model
Authors: P Leckie, A Proven, C Thiel, K Thiel, M Schenk, R Flieg, M Storr, R Jalan, N Davies
Journal: Gut (2012)

<h3>Introduction</h3> Though the incidence of liver disease continues to increase, an effective liver support device remains an unmet clinical need. We have demonstrated that in liver failure, albumin function is irreversibly damaged, preventing detoxification processes, and that bacterial endotoxins induce systemic inflammation and neutrophil dysfunction. To date, toxin removal devices have failed to demonstrate clinical efficacy, which may be due to an inability to address albumin damage and/or inflammation. An albumin replacement system with a novel endotoxin ligation (ARSeNEL) component was developed to selectively to adsorb endotoxin and replace damaged albumin in patients9 plasma. <h3>Methods</h3> We tested the device in an acetominophen model of acute liver failure (ALF). 16 female landrace pigs (eight ALF, five ALF + UCL-ARSeNEL) were studied. Irreversible ALF was induced by acetaminophen administration via a jejunel catheter, confirmed by deranged clotting function (PT &gt;30% normal). Treatment was with UCL-ARSeNEL or CVVH control within 2 h of ALF confirmation. The ARSeNEL device consists of three components; plasmapheresis, endotoxin and high cut-off (100 kDa) filters; with fresh frozen plasma replacing ultrafiltered plasma. Endpoints were: survival; ICP; heamodynamic parameters, standard biochemistry; cytokines; albumin damage; and plasma endotoxin levels. <h3>Results</h3> UCL-ARSeNEL significantly increased survival post ALF (ALF 15.8±2.4 h vs UCL-ARSeNEL 23.8±1.9 h; p=0.02). Endotoxin reduced by a quarter (1.99±0.18 Eu/ml vs 1.42±0.21 Eu/ml) in the device group at 16 h. The changes in ICP index (1.7±0.07 vs 1.4±1.58), INR (16.6±6.6 vs 6.8±0.5), ischaemia-modified albumin ratio (0.45±0.166 vs 0.35±0.108), noradrenaline requirement (61.11±15.4 vs 28.7±15.2 μg/Kg), and mean arterial pressure (71±7.6 vs 87±6.0 mm Hg) showed marked improvement in the UCL-ARSeNEL group. Measured inflammatory cytokines IL8, IL6, IL1b, TNFa and neutrophil activation (spontaneous burst p=0.03) were all found to be reduced in the ARSeNEL treated group compared with ALF control. <h3>Conclusion</h3> These results confirm that UCL-ARSeNEL improves survival in ALF by addressing key pathophysiological derangements such as albumin dysfunction and endotoxinaemia; which impact upon systemic inflammation and end-organ function. The reduction in inflammation is associated with improved vascular function and reduced inotropic support requirements. <h3>Competing interests</h3> None declared.
Confidential inquiry helps to minimise maternal risks
Journal: BMJ (1998)

Tobacco will kill a third of the young men in China China now consumes a third of the world's cigarettes, and on pp 1411 and 1423 Liu et al and Niu et al report large nationwide retrospective and prospective studies of the hazards of tobacco, with closely concordant results.The pattern of disease caused by smoking varies widely from one part of China to another, and between China and the West, but the overall risk is substantial and growing.In Britain and America about half of all persistent cigarette smokers are eventually killed by tobacco, and about the same overall risks will be seen in China.Two thirds of the young men become persistent smokers, so about 100 million of the 0.3 billion Chinese men now aged 0-29 will be killed by tobacco in middle or old age.
The Arthropathies; a Handbook of Roentgen Diagnosis
Journal: Annals of the Rheumatic Diseases (1944)

have been the development of true tuberculous arthritis in one of the affected joints, but this did not happen.The experience at Sidcup of over 350 consecutive cases of tuberculous pleural effusion (Heaf and Ellingworth, 1944) shows that transitory tuberculous bacillaemia is not uncommon in the course of this disease.Apart from the more obvious cases of
Changed levels of endogenous sex steroids in women on oral contraceptives
Authors: M Ahmed-Taha, T Akhtar, F S S Al-Ani, A Al-Atraqchi, F Ai-Azawi, K Al-Baghdadi, A Al-Chalabi, El-K Ali, A Al-Kaabi, Q Alrahim, Layla Al-Roomi, J Andrews, A Arnold, J Aryasingha, A Ategbole, G Atherstone, R Barber, A Barnouti, A Batchelor, Susan Bayley, Judith Beardshaw, Judith Behrens, A Bird, Ann Blackburn, D Blake, A Bodger, D Borsey, R Boyle, Elizabeth Braidwood, S Breathnach, R Brettle, A Briggs, A Brown, M Brown, J Bullen, J Burness, S Callaghan, A Carless, J Carnie, Dianne Carter, Y Chan, M-C Chan, Y-M Che, K-O Cheung, P-N-S Chitson, S Chiu, G Choi Kin, C Chua, C Clark, Vicky Clement-Jones, I Cobden, J Cohen, M Conway, S Cook, R Coppen, J Couriel, Elizabeth Cowden, F Cunningham, M Cushley, Mollie Dada, M Dancy, J David, G Davidson, S De Silva, R Doghmi, Kathryn Donmall, G Dowey, P Duckett, Elizabeth Dufton, M Dunn, Alison Dutt, M Earley, A Hag, S El-Hag, El-H Elidrissy, D Elliman, J Elliott, J Ellis, M Elrawadi, R Epstein, J Fitzpatrick, R Fletcher, J Fordham, J Forster, J Freeman, J Garnett, J Gatus, L Gerlis, A Girdwood, R Goldberg, S Goyal, Vanessa Graham, W Gray, S Greene, A Grieve, R Grieve, K Gupta, J Halsey, M Hamad, P Harrison, E Haworth, Jacqueline Hayden, S Hegde, T Henderson, J Hewitt, J Hirst, F Hiwaizi, Irene Hodsman, P Horrocks, C Howard, S Hughes, P Ind, E Iwuagwu, D De, S Jayasinghe, D Jeffs, P Jenkins, F Jenkins, D Jones, M Jones, H Kaldas, D Kar, A Karnik, M Karthigasu, J Kelly, J Kelnar, J Kendra, J Kenicer, D Kennedy, J Kiernan, Jennifer Kilvert, Angela Kirby, G Kopelman, M Lall, Doreen Latt, Ann Lawson, F Leahy, T Lee, W Lenney, J Leopold, J Lips, D Lloyd, J Long, D Ludwin, J Mccallum, M Mccarthy, D Macintyre, J Mckenna, R Mckenzie, A Macnair, A Mcninch, R Mcwilliam, J Mahood, M Malla, A Manhire, I Manifold, M Masser, G Mastaglia, P Mathew, M Mathew, Meenakshi Sundaram, C Middleton, J Miller, K Misch, Dorothy Mitchell, J Mitchell, A Mitra, R Mohiuddin, M Molloy, G Morgan, J Morris, J Muir, M Murphy, M Nazer, R Nesbit, A Newland, Catherine Ng, Mui Nam, Helen Nutbeam, Anne Nutter, A Oakhill, J Connell, P O'malley, J Owen, E Parker, G Patterson, J Patton, A Peacock, Jennifer Pearce, R Peppiatt, E Phillips, G Pickering, T Pierscianowski, Y Pok, Linda Pololi, K Popat, D Raper, K Rassam, B Rassam, M Reynolds, A Riley, K Roberts, J Roberts-Thomson, G Rogers, Elizabeth Rowse, Elizabeth Ruffell, J Ryan, A Salih, N Samarasiri, J Sampson, S Sankarapandian, M Sankoh, D Scott, G Sekoni, Z Siddiqi, G S Q Silva, C Sirinavin, B Skidmore, R Slade, A Smith, Mary Smith, Elizabeth Smith, G Spence, G Spencer-Jones, N Sreeharan, T Staunton, C Steer, P Stephens, Georgina Stewart, S Sullivan, S Sundaralingham, R Suri, C Tait, Adele Tan, Guat Kean, Tan Har, The Hon, R Tedder, T Thamotharampillai, Joan Thomas, A Timmis, Hoon Chin, Gladys Tinker, B Tomlinson, A Torode, Catherine Trewby, J Verster-Cohen, D Wade, J Wade, G Walford, Angela Walker, P Warren, A Weindling, R Wijenayake, L Wijesuriya, M Wijesuriya, A Williams, R Williams, H Williams, T Wilmshurst, J Wilson, D Wilson, R Winter, M Wong, I Wood, Victoria Wood
Journal: BMJ (1976)

the month was 1113.
SEX AND MEDICINE
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase II, Single-Center, Open-Label Study of Oral Panobinostat in Combination with Lenalidomide and Weekly Dexamethasone in Patients with Multiple Myeloma
Authors: Ajai Chari, Hearn J. Cho, Samir Parekh, Amishi Dhadiwal, Katarzyna Garcia, Natalie Belostotsky, Donna Catamero, Arlynn Brion, Lauren Cardone, Juliet Escalaon, Daniel Verina, Moon-hee Yum, Lisa La, Jude Gullie, Elaine Chan, Sundar Jagannath
Journal: Blood (2014)
原发性免疫缺陷的皮肤症状--如何找到要检查的基因
Authors: M. Ettinger, J. Schreml, K. Wirsching, M. Berneburg, S. Schreml
Journal: British Journal of Dermatology (2018)

原发性免疫缺陷是一种罕见的慢性疾病,患者的一部分免疫系统可能会存在缺失或功能紊乱的现象,因而导致免疫系统减弱,患者更易感染会引起传染病的细菌。患者会出现各种症状,但共同点是都会存在反复、持久且/或严重的感染,有时是因罕见细菌引起的。近半数患者会出现皮肤症状,这有助于医生辨别潜在的免疫紊乱问题。因此,本研究的作者制作了一张表格,便于医生在疑似免疫缺陷的情况中根据皮肤症状来诊断免疫紊乱的问题。他们列出了典型的皮肤表现以及需要检查的相应疾病和基因。
Abstract P287: Systematic Review of Dietary Trans-fat Reduction Policies: Evidence for an Effectiveness Hierarchy?
Authors: Lirije Hyseni, Helen Bromley, Chris Kypridemos, Martin O’Flaherty, Ffion Lloyd-Williams, Maria Guzman-Castillo, Jonathan Pearson-Stuttard, Simon Capewell
Journal: Circulation (2017)

Background: The four major risk factors prioritised in WHO non-communicable disease prevention strategies are tobacco, alcohol, physical inactivity and, crucially, poor diet. Trans-fatty acid intake in most countries still exceeds the WHO target of 2g/day, mainly reflecting consumption of industrial trans-fats in junk food. Furthermore, the most effective policies for reducing trans-fats remain unclear. We therefore systematically reviewed the evidence on trans-fat policy interventions to inform future prevention strategies. We also explicitly compared “upstream” interventions covering whole populations with “downstream” interventions targeting individuals. Methods: A pre-piloted search strategy was used to systematically search six electronic databases (Cinahl, CRD, CDSR, Medline, SCI and SCOPUS) for papers evaluating the effectiveness of trans-fat interventions, with intake (g/day) as the main outcome measure. Two researchers independently screened, extracted and graded the papers for quality. Each study was then categorised on a continuum ranging from “downstream” interventions targeting individuals (dietary counselling, media campaigns or nutrition labelling) to more “upstream” structural interventions covering the entire population - reformulation, regulation, fiscal policies and comprehensive strategies involving multiple policies. A narrative synthesis was used to summarise and compare the effectiveness of different interventions. Results: After screening 996 candidate papers, a total of 22 papers were included in this systematic review: 12 empirical studies and 10 modelling studies. Quality was variable. The largest trans-fat reductions occurred in Denmark. Multiple interventions decreased intake from 4.5g/day in 1976 to 1.5g/day in 1995 and then virtually zero after a legislative ban in 2005. The US now intends to emulate this approach. No studies quantifying tax interventions were identified. Voluntary reformulation reduced trans-fat intake by 1.5g/day followed by worksite interventions (1.2g/day) and food labelling (0.8g/day). Dietary counselling targeting individuals achieved the smallest reductions (0.8g/day). Conclusions: Multi-component interventions including a legislative ban to eliminate trans-fats from foods appear the most effective strategy to minimise intake, as achieved in Denmark, and ongoing in the US. However this approach remains underused. Reformulation and other multi-component interventions can also achieve useful reductions. By contrast, more “downstream” interventions targeting settings or individuals consistently achieve much smaller reductions. This “effectiveness hierarchy”, previously observed in tobacco and alcohol control, might perhaps be considered more often when planning future prevention strategies; for instance to control other harmful nutrients such as salt or sugar.
National HIV Testing Day — June 27, 2018
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

National HIV Testing Day, June 27, highlights the importance of testing in detecting, treating, and preventing human immunodeficiency virus (HIV) infection.Awareness of HIV infection through HIV testing is the first step to prevention, health care, and social services that improve life quality and length of survival (1).Health care providers and others providing HIV testing can reduce HIV-related adverse health outcomes and risk for HIV transmission by implementing routine and targeted testing to decrease diagnosis delays (2).In this issue, an analysis of national population-based survey data collected during 2006-2016 found that persons with higher risk for HIV in the past year did not achieve CDC's recommended frequency of at least annual screening and the median time between tests did not change (3).Health care providers and public health practitioners need to intensify efforts to routinely screen all patients for HIV infection, and to identify persons with ongoing risk and ensure that they are engaged in annual screening for HIV infection.Additional information on National HIV Testing Day is available at https://www.cdc.gov/features/HIVtesting.Basic testing information for the public is available at https:// www.cdc.gov/hiv/basics/testing.html.Additional information on HIV testing for health professionals is available at https://www.cdc.gov/hiv/testing.CDC's guidelines for HIV testing of serum and plasma specimens are available at https://www.cdc.gov/hiv/guidelines/testing.html.
Transactions of the South Carolina Medical Association.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical school applicants and the shortage of physicians
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes Mellitus
Authors: Samuel B. Beaser
Journal: New England Journal of Medicine (1958)

DiagnosisThe glucose oxidase enzyme paper† method of urine testing is specific for screening134 135 136 137 and differentiating138 glycosuria, but its lack of accuracy above concentrations of 0.5 to 1 per cent detracts from its usefulness as a routine method for diabetic management. Attempts to apply this technic to blood139 and conjunctival-fluid140 sugar or to use test-tablet methods for blood sugar141 , 142 have achieved only a screening level of accuracy. However, one accurate and specific blood sugar method has been proposed that uses the glucose oxidase reaction.143 The comparative absorptive capacity of stomach and small intestine for glucose was measured in the rat. . . .
LIGHT AND GROWTH
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interaction of steroid hormone receptors with the transcription initiation complex
Authors: M. Beato
Journal: Endocrine Reviews (1996)

REGULATION of gene expression by steroid hormones is a traditional field of molecular endocrinology. The hormones act by binding to intracellular receptors, which themselves orchestrate the transcriptional response. After the cloning of the hormone receptors and the identification of their target sequences on DNA at the end of the 1980s, the question of how steroid hormones modulate the activity of various genes in target cells seemed to be solved. It was clear that steroid hormone receptors are ligand-activated transcriptional modulators, which in most cases act through binding to specific sequences on DNA called hormone-responsive elements (HREs) (1). Careful mutational analysis identified a modular structure of the receptors composed of a DNA-binding domain, nuclear localization signals, a ligand-binding domain, and several transactivation domains (2). Interactions of the receptors with components of the basal transcriptional machinery and with sequence-specific transcription factors were assumed to mediate their transcriptional effects. The prevalent opinion was that the mechanism of action of steroid hormones was a closed chapter ready for the textbooks and what remained to be done to complete the picture was merely the collection of details.
Discordant intracoronary brachytherapy results in adult mini-pig versus juvenile farm pig restenosis models: How useful are these models for predicting safety and efficacy in man? J�rg Hausleiter, Alex Li, Kaname Takizawa, Arik Finkelstein, Raj Makkar, Neal Eigler, James Whiting. Cedars-Sinai Medical Center, Los Angeles, CA, German Heart Center, Munich, Munich, Germany
Journal: Journal of the American College of Cardiology (2001)
A prospective cohort study of quality of life after acute myocardial infarction at sites with and without coronary angiography Louise Pilote, Thao Huynh, Lawrence Joseph, Jean G. Diodati, Normand Racine, Fran�ois Charbonneau, Claude L�vesque, Claude Lauzon, Suzanne Carignan, Danielle Dion, Ren� Roux, Pouliot Jo�l, Mark J. Eisenberg. Montreal General Hospital, Montreal, PQ, Canada
Journal: Journal of the American College of Cardiology (2001)
Cardiac involvement in Friedreich's ataxia.
Journal: BMJ (1978)

peace of mind.Such a policy must not, however, be adopted in prepubertal girls.Anxious parents commonly bring a girl aged between 8 and 12 to a breast clinic with a 1-2 cm discoid mass beneath one nipple.The mass is due to asymmetrical development of the breast disc of early puberty.Surgical interference in such a case is a catastrophe: removal of the breast disc at this stage will inevitably mean complete failure of development of the breast on that side.
Pain Syndromes: Treatment by Paravertebral Nerve Block
Journal: JAMA (1949)

This book is an unusual monograph on the interpretation of pain.The authors believe that the presence of tenderness, and its distribution, whether local or segmental, is of great aid in diagnosis and therapy.Their premises are that the combination of segmental pain and tenderness are usually due to factors which irritate roots, ganglia or trunks of the spinal sensory nerves, rather than to painful impulses orig- inating in diseased viscera.In other words, pain and seg- mental tenderness of skin in most instances appears to them to be of somatic rather than of visceral origin.As in many theses, sometimes the implications go beyond the demonstration of the proof.However, the book has much to offer.In Chapter II, for example, the desirability of improvement of posture is emphasized and the way to accom- plish it is pointed out.In Chapter IX it is brought out that pronounced pain and tenderness of the abdomen, as a car- dinal symptoin, is not caused by adhesions unless other symptoms are also present.In chapters III and VIII the authors return again and again to their main thesis, that persistent segmental pain is the result of lesions in or affect- ing the spinal nerves.In Chapter VIII, too, are developed arguments against the Head-McKenzie theory of visceral sensory reflex pain and the reliability of Murphy's sign.The last portion of the book is given to the technique of inijection for neuralgia.The photographs and diagrams are