tbuckley/cabot-search huggingface dataset:
Physiological Limitations of Performances During Acceleration
Journal: JAMA (1963)

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IS CODEIN A HABIT-FORMING DRUG?
Journal: JAMA (1922)

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Intracerebral Hemorrhage
Authors: Mario Di Napoli
Journal: JAMA (2011)

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Arthritis &amp; Rheumatology
Journal: Arthritis & Rheumatology (2013)

Objective.To investigate the efficacy and safety of ixekizumab in patients with active radiographic axial spondyloarthritis (SpA) and prior inadequate response to or intolerance of 1 or 2 tumor necrosis factor inhibitors (TNFi).Methods.In this phase III randomized, double-blind, placebo-controlled trial, adult patients with an inadequate response to or intolerance of 1 or 2 TNFi and an established diagnosis of axial SpA (according to the Assessment of SpondyloArthritis international Society [ASAS] criteria for radiographic axial SpA, with radiographic sacroiliitis defined according to the modified New York criteria and ≥1 feature of SpA) were recruited and randomized 1:1:1 to receive placebo or 80-mg subcutaneous ixekizumab every 2 weeks (IXEQ2W) or 4 weeks (IXEQ4W), with an 80-mg or 160mg starting dose.The primary end point was 40% improvement in disease activity according to the ASAS criteria (ASAS40) at week 16.Secondary outcomes and safety were also assessed.Results.A total of 316 patients were randomized to receive placebo (n = 104), IXEQ2W (n = 98), or IXEQ4W (n = 114).At week 16, significantly higher proportions of IXEQ2W patients (n = 30 [30.6%]; P = 0.003) or IXEQ4W patients (n = 29 [25.4%];P = 0.017) had achieved an ASAS40 response versus the placebo group (n = 13 [12.5%]),with statistically significant differences reported as early as week 1 with ixekizumab treatment.Statistically significant improvements in disease activity, function, quality of life, and spinal magnetic resonance imaging-evident inflammation were observed after 16 weeks of ixekizumab treatment versus placebo.Treatment-emergent adverse events (AEs) with ixekizumab treatment were more frequent than with placebo.Serious AEs were similar across treatment arms.One death was reported (IX-EQ2W group).Conclusion.Ixekizumab treatment for 16 weeks in patients with active radiographic axial SpA and previous inadequate response to or intolerance of 1 or 2 TNFi yields rapid and significant improvements in the signs and symptoms of radiographic axial SpA versus placebo.ClinicalTrials.
Erratum: A teratologic suppressor role for p53 in benzo[a]pyrene–treated transgenic p53–deficient mice
Authors: Carla Rosenberg', Ralph Florijn', Frans Van De Rijke, Lau Blonden', Tonk Raap, Gert-Jan Van Ommen', M Kamboh', Dharambir Sanghera, Robert Ferrell', Steven Dekosky'
Journal: Nature Genetics (1995)
DIAGNOSIS OF CHRONIC INTRA-OCULAR TUBERCULOSIS
Journal: JAMA (1920)

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Dysrhythmia Prophylaxis
Authors: Thomas Killip
Journal: New England Journal of Medicine (1969)

More than 50 years ago de Boer showed that an electrical stimulus delivered to the vertebrate heart at an appropriate moment in diastole induced repetitive ventricular extrasystoles or fibrillation.1 Subsequently, Wégria and Wiggers defined the vulnerable period.2 The myocardium that is refractory very early in electrical diastole will later respond to a strong stimulus with repetitive activity. The heart is thus vulnerable to fibrillation when a stimulus of proper strength is applied at the proper time.These observations appeared to have little clinical import until Smirk noted that a group of patients with ventricular extrasystoles closely coupled to the preceding . . .
ORGANIZATION SECTION
Journal: JAMA (1941)

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Correction
Authors: G Bulow To Be Surgeon, R Macpherson, W Miln, R Vass, E Vella, M Munro, J Rooney, T Ryan, D Cowan, J Kilgour, R Evans, J Power, G Harris, A Henderson, H Naddell, H Hambury, G Gregg, J Cardwell, J Horler, J Whitmore, F Griffiths, J Holman, J Mclelland, H Thompson, T Glenister, J Butterfield
Journal: BMJ (1962)
Comparative Study of 9-Alpha-Bromo-11 Ketoprogresterone and Prednisolone in the Treatment of Advanced Carcinoma of the Female Breast
Journal: JAMA (1963)

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Commentaire de travail de D. von Renteln et al., pp. 1056
Journal: Endoscopy (2009)

See also: Randomized controlled trial comparing endoscopic clips and over-the-scope clips for closure of natural orifice transluminal endoscopic surgery gastrotomiesEndoscopy 2009; 41(12): 1056-1061DOI: 10.1055/s-0029-1215241
MACK-3: an accurate blood test for the diagnosis of fibrotic NASH and a candidate biomarker to monitor disease progression
Authors: Clémence Canivet, Valérie Moal, Floraine Zuberbuhler, Lannes Adrien, Sophie Michalak, Marine Roux, Frédéric Oberti, Isabelle Fouchard, Paul Cales, Jerome Boursier
Journal: Journal of Hepatology (2020)
Modern Concepts of Communicable Disease
Journal: JAMA (1953)

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Software
Journal: JAMA (1990)

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Filing Complaints Against Residency Programs: Part II
Journal: JAMA (1995)

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WMA's Declaration of Helsinki Serves as Guide to Physicians
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the American Dermatological Association.
Journal: JAMA (1899)

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Uric acid metabolism and tubular sodium handling. Results from a population-based study
Authors: F. P. Cappuccio
Journal: JAMA (1993)

<h3>Objective.</h3> —To define the relationship, if any, between uric acid metabolism (serum and urinary levels) and proximal tubular sodium handling in a sample of general male population. <h3>Design.</h3> —Cross-sectional survey of a sample of the male working population conducted as part of a nationwide survey of the prevalence of cardiovascular risk factors. <h3>Setting.</h3> —The Olivetti factory in Pozzuoli, a suburb of Naples, Italy. <h3>Participants.</h3> —Five hundred sixty-eight untreated male workers aged 21 to 68 years (90.8% of those eligible). <h3>Measurements.</h3> —Anthropometry, blood pressure, blood tests, a detailed questionnaire, and urinary measurements on a fasting timed collection after a 300-mg lithium carbonate capsule was taken the night before the investigation. <h3>Results.</h3> —Serum uric acid level was inversely and significantly associated with the fractional excretion of lithium (<i>r</i>=-.22,<i>P</i>&lt;.001), ie, the higher the serum uric acid level, the greater the amount of sodium reabsorbed at nephron sites proximal to the distal tubule. The association was graded and independent of possible confounders such as age, body mass, smoking, wine consumption, blood pressure, fractional excretion of sodium, and serum creatinine (<i>R</i><sup>2</sup>=.34,<i>P</i>&lt;.001). <h3>Conclusions.</h3> —High serum uric acid levels are independently associated with increased proximal tubular sodium reabsorption in men. This relationship suggests an altered tubular sodium handling and uric acid metabolism consistent with hyperinsulinemia, insulin resistance being the possible pathophysiological link. (<i>JAMA</i>. 1993;270:354-359)
Treatment of Classic Hemophilia: The Use of Fibrinogen Rich in Factor VIII for Hemorrhage and for Surgery
Authors: Campbell W. McMillan, Louis K. Diamond, Douglas M. Surgenor
Journal: New England Journal of Medicine (1961)

CLASSIC hemophilia, comprising about 80 per cent of the heritable coagulation disorders, is characterized by a hemostatic defect largely attributed to deficiency of a clot-promoting principle in the fresh plasma of affected persons. This principle, popularly known as AHG (antihemophilic globulin) or AHF (antihemophilic factor) and officially known as factor VIII, is quantitatively related to thromboplastin generation in vitro and to hemostatic efficiency in vivo. Restoration of plasma factor VIII activity to a clinically useful extent is generally accepted as the rational foundation of the specific therapy of classic hemophilia.In most cases of classic hemophilia factor VIII deficiency appears . . .
Infectious Diseases
Authors: Mark Stoeckle
Journal: JAMA (1995)

Cryptosporidiosis is increasingly recognized to be a major cause of diarrheal disease in the United States. Cryptosporidiosis is a self-limited disease in immunocompetent persons, although symptoms may be prolonged, with an average duration of 2 weeks in patients who seek medical attention. In persons infected with the human immunodeficiency virus (HIV),<i>Cryptosporidium</i>causes a severe, unremitting diarrhea, often associated with biliary disease. The agent,<i>Cryptosporidium parvum</i>, is a protozoan parasite that is transmitted by fecally contaminated water and food and from person to person. The importance of cryptosporidiosis was dramatically highlighted in 1993 by a massive outbreak in Milwaukee, Wis, where an estimated 400 000 persons developed diarrheal disease due to contamination of the public water supply.<sup>1</sup>Cryptosporidial infection is endemic among domestic and wild animals, and the Milwaukee outbreak appeared to be due to spring runoff from livestock grazing areas into the municipal watershed. The cryptosporidial cysts are
ENCEPHALOMYELITIS IN MICE
Journal: JAMA (1941)

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