tbuckley/cabot-search huggingface dataset:
Plasma von Willebrand factor antigen (vWF:AG) and thrombomodulin (TM) levels in adult thrombotic thrombocytopenic purpura/hemolytic uremic syndromes (TTP/HUS) and bone marrow transplant‐associated thrombotic microangiopathy (BMT‐TM)
Authors: Z.R. Zeigler, C.S. Rosenfeld, D.F. Andrews, J. Nemunaitis, J.M. Raymond, R.K. Shadduck, R.E. Kramer, J.F. Gryn, P.B. Rintels, E.C. Besa, J.N. George
Journal: American Journal of Hematology (1996)

Endothelial damage is thought to be a contributing factor in the pathogenesis of Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndromes (TTP/HUS). The present studies measured two markers of endothelial cell stimulation and/or activation [von Willebrand Factor (vWF:Ag) and thrombomodulin (TM)] in patients with TTP/HUS disorders and compared them to controls. The patient groups consisted of adults with TTP/HUS, with (n = 13) and without (n = 14) peak Cr levels >2.0 mg/dl. Additionally, 52 patients with Bone Marrow Transplant-associated Thrombotic Microangiopathy (BMT-TM) following allogeneic BMT were evaluated. Both vWF:Ag and TM were elevated in all patient groups compared to controls. TTP/HUS patients with peak Cr >2.0 mg/dl had higher TM levels (P <0.001) than did those with peak Cr levels below 2 mg/dl. However, thrombomodulin/creatinine (TM/Cr) ratios did not differ in these two groups nor did they differ from controls. BMT-TM pts had higher vWF:Ag levels and higher TM/Cr ratios than controls and TTP/HUS, P < 0.001. The median TM/Cr ratio in BMT-TM was 91 (range = 34–229) compared to 38 (range = 29–50) in controls, P < 0.001 and 38 (range = 6 to 156) in TTP/HUS, P < 0.001. Additionally both TM (P < 0.001) and TM/Cr (P < 0.02) were higher in patients with Grades 3 and 4 BMT-TM compared to those with Grade 2 BMT-TM. These results suggest that endothelial cell activation occurs in TTP/HUS and BMT-TM. Since TM/Cr ratios were higher in BMT-TM compared to TTP/HUS, these findings suggest that the mechanism of elevated TM in BMT-TM cannot be explained solely by altered renal excretion. Taken together, these findings strongly indicate a role of endothelial cell damage in BMT-TM. © 1996 Wiley-Liss, Inc.
Independence and the Presidency
Journal: BMJ (1970)

should be mandatory, rather than exploration.Secondly, the aetiological classification suggested in this interesting article should include amoebiasis.This disease is not limited nowadays to tropical areas and it is known to mimic many intra-abdominal emergencies.'It is especially apt to cause colonic dilatation similar to pseudo-obstruction of the large bowel, and we know that exploration in these cases may be associated with high morbidity and mortality, though in cases of toxic megacolon of amoebic ori- gin a caecostomy may be life-saving.This is the only surgical procedure which I think is justified for pseudo-obstruction.If there is acute cholecystitis, then of course cholecys- tectomy or cholecystostomy are justified (Case 2), but then it is no longer pseudo- obstruction but sentinel ileus.-Iam, etc.
Induction of cMrp/cMoat gene expression by cisplatin, 2- acetylaminofluorene, or cycloheximide in rat hepatocytes
Authors: H Kauffmann
Journal: Hepatology (1997)

The human multidrug-resistance-associated protein (MRP), a member of the adenosine triphosphate (ATP)-binding cassette transporter superfamily, is frequently overexpressed in tumor cells resistant to antineoplastic drugs. In the rat, two Mrp isoforms have been identified, Mrp and cMrp. cMrp, also called Mrp2 or cMoat (canalicular multispecific organic anion transporter), is expressed in the canalicular membrane of rat hepatocytes and mediates the excretion of glucuronate, sulfate, and glutathione conjugates into bile. We investigated the expression of cMrp and Mrp in rat hepatocytes in primary culture. Treatment with the chemical carcinogen 2-acetylaminofluorene (2-AAF), the antineoplastic drug cisplatin, and the protein-synthesis inhibitor cycloheximide led to a dose-dependent and time-dependent increase in cmrp gene expression. A 347-base pair cmrp complementary DNA (cDNA) probe served to demonstrate the induction of cmrp messenger RNA (mRNA) with 40 micromol/L 2-AAF, 5 micromol/L cisplatin, or 5 micromol/L cycloheximide. An analogous response was obtained for the increase in cMrp protein. Mrp mRNA was below the detection limit in Northern blots of RNA from liver and hepatocyte cultures, in contrast to rat testis mRNA which served as a positive control. Immunofluorescence microscopy of cultured hepatocytes was used to visualize cMrp in the plasma membrane. Treatment with 2-AAF led to a marked increase in the immunofluorescence signal confirming the cMrp-inducing potency of 2-AAF. In conclusion, the inducing effect of the compounds studied may reflect a general inducibility of hepatic cMrp by a variety of cytotoxic, carcinogenic, and chemotherapeutic agents which is likely to be of relevance for the acquisition of multidrug resistance during chemotherapy and in the process of chemical carcinogenesis in the liver. (Hepatology 1997 Oct;26(4):980-5)
STARTLE NEUROSIS
Authors: FREDERICK C. THORNE
Journal: American Journal of Psychiatry (1944)

While acting as civilian neuro-psychiatric examiner at an army induction station from November 1940 to November 1943, the author encountered three cases presenting an interesting psychiatric syndrome characterized by hyperesthesias, excessive startle reactions to unexpected stimuli and associated personality reactions which may become incapacitating. Brief clinical studies are included of these three cases which suggest that some individuals showing the excessive startle reaction may become seriously incapacitated by undesirable personality reactions. The person's social difficulties begin when the nature of his disability is discovered and he becomes the victim of incessant and tormenting practical joking. The etiology of the syndrome is unknown but constitutional factors seem important. It is roughly estimated that the syndrome occurs with a frequency of 1 in 2000 among young adult males. It is suggested that the diagnosis of startle neurosis adequately describes this clinical syndrome. It is believed that it may be indicative of central nervous system instability and is a valid cause for rejection for military service.
Violence and Leveraged Community Treatment for Persons With Mental Disorders
Authors: Jeffrey Swanson
Journal: American Journal of Psychiatry (2006)

Objective: This article explores the link between violence and the practice of legally mandating treatment in the community or leveraging benefits from the social welfare system, such as subsidized housing and disability income support, to ensure adherence to treatment. Method: Data are presented from a survey of 1,011 persons with psychiatric disorders receiving treatment in public mental health service systems in five U.S. cities. Multinomial logit analysis was used to examine the association between physically assaultive behavior and experience of social welfare leverage, legal leverage, or both types of leverage, with the analyses controlling for demographic and clinical characteristics. Results: Across study sites, 18% to 21% of participants reported having committed violent acts in the past 6 months; 3% to 9% reported having used or made threats with a lethal weapon, committed sexual assault, or caused injury. About three-quarters of subjects who reported such serious violence also reported having experienced some form of leveraged treatment, compared with about one-half of subjects who did not report serious violence. Demographic and clinical factors that were independently associated with the likelihood of experiencing both types of leverage included younger age, male gender, poorer clinical functioning, more years in treatment, more frequent hospitalizations, higher frequency of outpatient visits, and negative attitudes toward medication adherence. Among participants who did not voluntarily take psychotropic medication, even minor assaultiveness was associated with having experienced legal leverage. Conclusions: A combination of concerns about safety and treatment nonadherence may influence decisions by clinicians and judges to apply legal leverage.
THE DIAGNOSIS AND TREATMENT OF PERFORATION OF ULCER OF THE STOMACH AND DUODENUM.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17378: Impact of Mitral Regurgitation on Left Ventricular Remodeling in Ischemic Cardiomyopathy
Authors: Weiwei Shi, Apoorva Girish, Shashi Bhushan, Muralidhar Padala
Journal: Circulation (2015)

Introduction: Mitral regurgitation (MR) developing secondary to a myocardial infarction(MI) is a clinical challenge, as its impact on adverse ventricular remodeling and dysfunction, and the role of mitral repair remains unknown. Using a novel rodent model, we sought to investigate the impact of MR on left ventricular remodeling and failure. Hypothesis: MR accelerates post-MI remodeling and impairs systolic function. Methods: Adult rats (~300g, N =49) were randomized to four groups: MR only(n=15); MR + MI (n=11); MI only(n=11); and sham(n=12). MR was induced by puncturing the mitral valve leaflet with a 23g needle inserted transapically into the beating heart with TEE guidance. MI was induced by permanent ligation of the left coronary artery. After 90-days of follow-up, TTE and invasive pressure-volume loops were obtained and the tissue collected. Data are presented as mean ± 1 standard deviation, and ANOVA was used for group comparison. Results: Ejection fraction significantly reduced from 56.6 ± 10.7% in sham to 42.5 ±18.4% in MR, 42.6 ± 15.4% in MR +MI, and 37.5 ± 19.3% in MI groups (p&lt;0.05). ESV and EDV were significantly higher than sham in all the experimental groups, with MR+MI having the highest ventricular volumes. The slope of end systolic pressure-volume relationship (ESPVR) in MR, MI and MR+MI groups were 0.36± 0.19, 0.53±0.37, and 0.44±0.20 mmHg/μl, respectively, all of which were significantly reduced than sham(1.8 ±1.6 mmHg/μl), as shown in Figure 1. MI and MR+MI groups showed elevated left ventricular end-diastolic pressure (11.8± 3.3, 12.0 ±5.6 mmHg, respectively) compared to sham group (8.4 ±2.1mmHg). However, dP/dt min, Tau Weiss and Tau Glantz were unchanged. Conclusions: Systolic function is most compromised in MR+MI group compared to MR alone or MI alone at 90-days, whereas diastolic function was moderately impaired. This rat model provides a new platform to study the therapeutic impact of different drugs on ventricular function in this valve lesion.
Diagnostic anatomo-topographique de l'obstruction artérielle coronaire. Sixième partie: La thrombose artérielle souspéricardique gauche, cause de l'ischémie aigüe du myocarde
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Non-Hodgkin's lymphoma for the nononcologist
Authors: W. N. Hait
Journal: JAMA (1985)

RECENT advances in the understanding of immunology have led to more precise classification of the non-Hodgkin's lymphomas (NHLs).<sup>1</sup>However, this precision has left the internist faced with a bewildering variety of classification schemes that may have engendered as much confusion as clarification. In this review we have attempted to present the development of current nosology in a manner that will help incorporate recent classifications into daily use. The early classification of lymphomas into giant-follicle lymphoma, lymphosarcoma, and reticulum cell sarcoma<sup>2</sup>did not accurately describe the wide variation in histological and clinical manifestations of the lymphoproliferative diseases. Therefore, there was a need for a better scheme of classification. <h3>CLASSIFICATION ACCORDING TO HISTOLOGY</h3> A major advance in the classification of lymphomas was proposed by Rappaport and co-workers in 1956<sup>1</sup>(Table 1). This scheme divided NHLs based on the architectural characteristics of the lymph node and the cytological characteristics of the
Junior Hospital Staff Contract
Authors: S. R. Brennan
Journal: BMJ (1975)

Nephrocalcinosis is a common problem faced in both paediatrics and neonates, which may need referral on to paediatric nephrology. This 15 min consultation aims to look at children of different age groups (neonates, children 1–5 years old and older children) looking particularly at history, examination, causes, initial investigations and management.
Trends in Human Immunodeficiency Virus Infection Among Civilian Applicants for Military Service — United States, October 1985-March 1988
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sarcoid myopathy.
Authors: P S Talbot
Journal: BMJ (1967)

Sixteen patients were given prophylactic A.C.T.H. after they had sustained head injuries.Each had shown radiological evidence of a fractured petrous bone and had had bleeding from the ipsilateral ear.The expected incidence in an untreated group of the same size would have been six patients showing delayed facial weakness.Only two patients developed delayed facial weakness.In both this occurred on the second day.In one it was mild and lasted only 10 hours; in the other it was complete and denervation occurred despite treatment.It seems that A.C.T.H. offers some protection against this complication of head injury.
A comparative study of risks for hepatocellular carcinoma and mortality in chronic hepatitis B patients initially treated with entecavir or tenofovir
Authors: Hyo Young Lee, Eileen Yoon, Dae Won Jun, Hyunwoo Oh, Sang Bong Ahn, Jae Yoon Jeong, Sung Eun Kim, Soung Won Jeong, Hyoung Su Kim, Jae-Jun Shim, Joo Hyun Sohn, Yong Kyun Cho
Journal: Journal of Hepatology (2020)
Medico-Legal and Medico-Ethical
Journal: BMJ (1894)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Medico-Legal and Medico-Ethical Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Onychectomy
Authors: T. R. Jacobson
Journal: JAMA (1969)

<h3>To the Editor:—</h3> A method which has been very successful for me has consisted of making an incision completely around the nail, carrying the incision deeply enough to remove the nail and the matrix in toto. The distal half of the phalanx is removed, smoothing the new bony surface, folding back the flap above the phalanx and suturing, shortening the toe by three eighths to one half of an inch.
The Scientific Exhibit
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Text-Book of Diseases of the Ear and Adjacent Organs.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gatt ME, Zhao JJ, Ebert MS, Zhang Y, Chu Z, Mani M, Gazit R, Carrasco DE, Dutta-Simmons J, Adamia S, Minvielle S, Tai Y-T, Munshi NC, Avet-Loiseau H, Anderson KC, Carrasco DR. MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma [published online ahead of print October 20, 2010]. Blood. doi:10.1182/blood-2009-11-253294.
Journal: Blood (2011)
Routine protective isolation: worth the trouble in neutropenic patients?
Authors: W. Golden
Journal: JAMA (1979)

Routine protective isolation procedures for granulocytopenic patients may not offer any more protection from infections than general ward care, according to results of a prospective study at the University of Wisconsin Center of Health Sciences, Madison. William M. Nauseef, MD, now a fellow in infectious diseases at Yale-New Haven Hospital, Conn, and coinvestigator Dennis G. Maki, MD, associate professor of medicine at Wisconsin, randomly assigned 37 neutropenic patients—most with a diagnosis of acute nonlymphocytic leukemia—to standard ward accommodations or private rooms with reverse isolation precautions. Protective isolation procedures entailed the usual gown, mask, and glove requirements for all visitors. The only modification of care given the ward patients was handwashing prior to patient contact. Moreover, the ward group was sent for diagnostic studies throughout the hospital without special precautions. Neither group received nonabsorbable antibiotics, sterilized food, or cutaneous disinfectants. Both were given the same antineoplastic therapy and supportive care. Surveillance
A piece of my mind. The history of Crete
Authors: S. H. Calmes
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal