tbuckley/cabot-search huggingface dataset:
Books in Brief
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Uric acid. A risk factor for coronary heart disease
Authors: E. D. Frohlich
Journal: JAMA (1993)

Uric acid metabolism is an important concern in many clinical disciplines. Just as "all that wheezes is not asthma," all hyperuricemia is not gout. Clearly, altered urate metabolism is intimately associated with gout. But abnormal serum uric acid concentrations are encountered regularly in such varied pathophysiological problems as hypertension, coronary artery disease, obesity, hyperlipidemia, diabetes mellitus, polycythemia, and toxemia of pregnancy. How can this alteration be related to such a disparate collection of diseases, none of which is gout? Of course, several of these problems are otherwise linked: coronary artery disease, hypertension, diabetes mellitus, and obesity. But this linkage still does not explain the fundamental cause of the altered uric acid levels. Uric acid is a circulating end product of purine metabolism whose concentration may be elevated in gout where uric acid may be deposited in the synovial joint to result in arthritis or in other tissues (eg, kidney) to
DETOXIFYING DEVICES IN THE LIVING BODY
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Epidemiology in Japan
Authors: Takeshi Hirayama
Journal: Environmental Health Perspectives (1979)

Patterns, change in occurrence, causative risk factors, and control strategy for cancer of each site in Japanese populations were studied by applying standard methods and techniques of biostatistics and epidemiology. As the results, cancers in Japan were classified into two groups: one on the decrease (stomach, cervix) and the other on the increase (lung, colon, pancreas, breast, prostate, urinary organs, leukemia). Analysis of vital statistics, national nutrition survey data, and on-going prospective study data revealed change in selective dietary intake and increase in cigarette consumption are the major factors responsible for such trend. Epidemiological characteristics and major risk factors of cancers of stomach, colon, pancreas, lung, breast, uterine cervix, ovary, endometrium, prostate, urinary bladder, and leukemia in Japan were summarized. A limited effect of mass screening was observed in the case of stomach cancer in addition to the strong effect of diet and nutrition. Cigarette smoking was confirmed to be the major causative factor of lung cancer in Japan. A close association of increased intake of animal fat and breast cancer risk in Japanese women was also observed.
Proceedings of the Connecticut Medical Society, 1897.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease
Authors: Birgit Hutter-Paier, Henri J. Huttunen, Luigi Puglielli, Christopher B. Eckman, Doo Yeon Kim, Alexander Hofmeister, Robert D. Moir, Sarah B. Domnitz, Matthew P. Frosch, Manfred Windisch, Dora M. Kovacs
Journal: Neuron (2010)
SARS Antibodies
Authors: Bridget M. Kuehn
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pertussis vaccine issues unsettled
Authors: J. Elliott
Journal: JAMA (1978)

A serious outbreak of pertussis in the British Isles, where more than 50,000 cases of the disease have occurred since Nov 1,1977, has hastened a debate over the usefulness of pertussis vaccine. While routine pertussis immunization in infants and young children generally has been practiced around the world for the past 25 years, concerns over vaccine effectiveness and side effects have now become prominent. An international symposium held recently at the National Institutes of Health (NIH), Bethesda, Md, at which more than 200 experts on bacteriologic vaccines spent three days discussing all possible aspects of<i>Bordetella pertussis</i>and its vaccine, did little to settle the controversy. "As with many other infectious diseases, there was a great decline in the rate of pertussis mortality before any vaccine was available," said Dr Gordon T. Stewart, head of the Department of Community Medicine at the University of Glasgow, Scotland, at a news conference
American Medical Association and the Railroads.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TENDERFOOT EXODUS FROM PANAMA.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I trial of sorafenib in high-risk hepatocellular carcinoma (HCC) patients after liver transplantation.
Authors: Abby B. Siegel, Anthony B. El-Khoueiry, Richard S. Finn, Charles Davic Blanke, Rosa Hidalgo, Robert S. Brown
Journal: Journal of Clinical Oncology (2013)

280 Background: LT offers long-term survival for HCC patients within the Milan criteria. For those outside, rates of recurrence are higher. There are no known treatments which decrease risk of recurrence post-transplant. We began a multicenter Phase I study of sorafenib in high-risk HCC patients after LT. Methods: Eligible subjects had pathologically proven HCC that was either (1) outside Milan (pre- or post-transplant), (2) poorly differentiated (Edmondson and Steiner grade 4), or (3) had vascular invasion at explant. We used a standard phase I dose-escalation design, beginning drug between 4 and 16 weeks after LT, with a planned duration of treatment of 6 months. Cohort dosages are as follows: (1) 200 mg q day (6 enrolled), (2) 200 mg BID (3 enrolled), (3) 200 mg/400 mg (3 enrolled), and (4) 400 mg BID. Correlative studies include circulating endothelial cells (CECs) and plasma biomarkers which are being collected prior to treatment, at 1 month, and at recurrence. Results: We have enrolled 12 patients, 11 are reported here. Mean age is 62; 64% had underlying HCV, 27% HBV, and 9% ETOH. 45% were outside Milan based on preoperative imaging. On explant, 36% had high grade pathology, and 18% had vascular invasion. Grade 3-4 toxicities seen in &gt;10% include: cytopenias (27% neutropenia), LFT abnormalities (T. bili 18%), HTN (18%), and diarrhea (18%). We are currently enrolling at the 3 rd dose level. We had 1 episode acute rejection at the 3rd dose level. CEC data are available for 8 patients, with a baseline range from 15-91, and 1 month range from 2-254. Mean follow up time is 18.0 months. 3 patients have recurred, one who was on drug for &lt; 1 month. Conclusions: To our knowledge, this is the only ongoing multicenter Phase I trial of sorafenib in the post-transplant setting in the US. Post-transplant sorafenib for high-risk patients is feasible, and toxicity has been manageable for the most part. DLT has not yet been defined. Clinical trial information: NCT00997022.
Trends in antimicrobial drug prescribing among office-based physicians in the United States
Authors: L. F. McCaig
Journal: JAMA (1995)

<h3>Objective.</h3> —To assess changes in oral antimicrobial drug prescribing by office-based physicians from 1980 through 1992, with emphasis on the treatment of otitis media and sinusitis and on the possible impact of demographic variables on such use. <h3>Design.</h3> —The National Ambulatory Medical Care Survey is a sample survey of office-based physicians in the United States conducted by the National Center for Health Statistics, Centers for Disease Control and Prevention. <h3>Setting.</h3> —Physicians' offices. <h3>Patients or Other Participants.</h3> —Physicians sampled for the 1980,1985,1989, and 1992 National Ambulatory Medical Care Surveys, which included groups of 2959,5032,2540, and 3000 physicians, respectively. Sample physicians responding in 1980, 1985, 1989, and 1992 reported data for 46081, 71 594, 38384, and 34 606 sample office visits, respectively, including information on antimicrobial drug prescribing. <h3>Main Outcome Measure.</h3> —Trends in the antimicrobial drug prescription rates. <h3>Results.</h3> —From 1980 through 1992, increasing prescribing measured by the annual drug prescription rate per 1000 population, was found for the more expensive, broad-spectrum antimicrobial drugs, such as the cephalosporins; decreasing rates were observed for less expensive antimicrobial drugs with a narrower spectrum, such as the penicillins. No trend was found for trimethoprim-sulfamethoxazole, the erythromycins, or the tetracyclines. During the decade, an increasing trend in the visit rate to office-based physicians for otitis media was observed, while the visit rate for sinusitis among adults was found to be higher in 1992 than in each of the other study years. <h3>Conclusions.</h3> —The increased use of broader-spectrum and more expensive antimicrobial drugs have implications for all patients because of the impact on health care costs and the potential for the emergence of antimicrobial resistance. The data suggest that the incidence of otitis media and sinusitis is increasing. (<i>JAMA</i>. 1995;273:214-219)
Past and Present
Authors: Keith Wrenn
Journal: Annals of Internal Medicine (2003)

On Being a Doctor20 May 2003Past and PresentKeith Wrenn, MDKeith Wrenn, MDFrom Vanderbilt University School of Medicine; Nashville, TN 37232-4700.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-10-200305200-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I went to a meeting this week and confronted my past. I went to see if I could learn anything new about electrocardiograms. The room was full of internists of all ages. Most were there for a final cramming session before they took a test that would supposedly pronounce them competent at reading tracings, or not. This test, it seems, would ensure their continued ability to bill for electrocardiogram interpretation.Several smart young cardiologists filled the hours with a mix of fact and impression. With computerized slide presentations and laser pointers, they talked about how an ST segment's appearance indicated ... Author, Article, and Disclosure InformationAffiliations: From Vanderbilt University School of Medicine; Nashville, TN 37232-4700.Corresponding Author: Keith Wrenn, MD, Vanderbilt University Medical Center, 703 Oxford House, Nashville, TN 37232-4700; e-mail, keith.[email protected]vanderbilt.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 May 2003Volume 138, Issue 10Page: 847KeywordsComputersCoronary arteriesElectrocardiographyFearHearingIschemiaKneesLeft ventricleTachycardiaVentricular tachycardia ePublished: 20 May 2003 Issue Published: 20 May 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Felt Image
Authors: Caryn Russell
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bibliomania
Authors: C. G. Roland
Journal: JAMA (1970)

Although bibliomania has existed as long as there have been books, the condition had no generally accepted name until about a century and a half ago. Then a physician in Manchester, England, published a poem entitled "Bibliomania" (reprint, Philadelphia, 1866), dedicating it to a bibliomaniac friend. John Ferriar was the physician, Richard Heber the friend. John Ferriar (1761-1815) studied medicine at Edinburgh, graduating in 1781. Although he conducted a busy medical practice for the remainder of his life, he also achieved a contemporary reputation based in large part upon his studies of Massinger, the dramatist, and Lawrence Sterne. Ferriar also published poetry, a play, lengthy autobiographical reflections, and essays on a variety of medical, literary, and philosophical topics. Richard Heber (1773-1833), an Oxonian of independent wealth, early in life developed an unquenchable interest in books. So great was his aquisitive spirit that when he died, he left a total of
EMCDDA publishes 2012 report on the state of the drugs problem in Europe
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2012)

Preview this article: EMCDDA publishes 2012 report on the state of the drugs problem in Europe, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/46/art20315-en-1.gif
EFFICIENCY IN HOUSEHOLD DISINFECTION WITH FORMALDEHYDE AND THE AUTOCLAVE, AND WITH A MINIMUM OF INJURY TO FABRICS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Constrictive pericarditis following irradiation therapy
Authors: C. A. Macleod
Journal: JAMA (1969)

Constrictive pericarditis was found in a patient receiving mediastinal irradiation for metastatic seminoma. The gradual onset of symptoms following irradiation, together with the absence of features commonly associated with the more common causes of constrictive pericarditis, are highly suggestive of a causal relationship.