tbuckley/cabot-search huggingface dataset:
Antihistamine Substances
Authors: H. Dale
Journal: BMJ (1948)

As one of those who took part in the recognition of hista- mine in nature and in the first detailed examination of its intense physiological activities, I shall try to avoid the temptation to be unduly reminiscent.I may just remind you that at that time, nearly 40 years ago, much interest in circles concerned with experimental pathology was centred on the syndrome of the anaphylactic reaction and on the curious differences which it presented in the different species.You can imagine that Laidlaw and I (Dald and Laidlaw, 1910, 1911) had to discipline our eagerness as we examined one by one the actions of histamine on the different organs and systems of the dog and the guinea-pig in particular, and found them fitting neatly, like units of a jigsaw puzzle, into the contrasting pictures of the anaphylactic reactions in those two species as others had then recently described them.Biedl and Kraus (1910) had already drawn attention to the close correspondence-even closer, in fact-between the contrasted reaetions of the normal dog and guinea-pig to intravenous Witte's peptone and those of the anaphylactic dog and guinea-pig to the reinjection of the antigen.I well remember Biedl's account of this at the International Physiological Congress in Vienna in 1910; and my own decription later in the same programme of the newly discovered and, except for a few points, identical effects of histamine on the same two
Thyroxine Therapy
Authors: Alastair J.J. Wood, Anthony D. Toft
Journal: New England Journal of Medicine (1994)

Thyroxine therapy is given to replace thyroid hormone secretion when it is deficient (hypothyroidism) and also in certain circumstances when suppression of thyrotropin secretion is considered to be of value, such as in patients with thyroid carcinoma. It is perhaps surprising that any problems are perceived, other than compliance, with a treatment that has been available in one form or another for over a century. However, the availability of increasingly sensitive assays for thyrotropin1 has led to controversy about the dose of thyroxine needed for replacement therapy and about the safety of long-term suppressive treatment. Other issues include whether patients . . .
Immunologic Aspects of Renal Disease
Authors: John H. Peters, Philip Freedman
Journal: New England Journal of Medicine (1959)

Autoantibodies and Antigenicity of the KidneyIn 1939 Schwentker and Comploier67 started a new era in the development of experimental nephritis when they produced "autoantibodies" to rabbit kidneys. They immunized rabbits with homologous rabbit-kidney extract that had previously been incubated with streptococcal or staphylococcal toxin. By this means they were able to demonstrate complement-fixing antibodies to normal rabbit kidney. When homologous rabbit kidneys without the addition of toxin were used as antigen, no antibodies were produced. Unfortunately, they did not report histologic studies in the kidneys of these animals.In 1941 Parks and Shanks68 attempted to make rabbit kidneys "autoantigenic" . . .
Neurology in Art
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histology
Authors: Lester S. King
Journal: JAMA (1966)

<b>Microfabric of Man: A Textbook of Histology</b>, by Warren Andrew, 392 pp, 381 illus, $11, Chicago: Year Book Medical Publishers, Inc., 1966. Histology forms a major base for medical education. Consequently, teachers face a constant challenge to make this subject meaningful and interesting to the medical student. The recent developments in microscopic anatomy, the great progress in histochemistry and electron microscopy, the complex interrelations affecting tissue development, represent exciting fields of research which stimulate the investigator, yet at the same time pose problems for the teacher. How much should be presented to a medical student? The instructor must present enough of the "new" developments to stimulate the student, yet enough of the "old" to provide a firm foundation for his later work. Morphologic details given only for their own sake are boring, but details which fit in with the whole exciting story of human biology are meaningful to the student.
Table of Contents
Authors: Christina Wyatt, Girish Nadkarni, Barbara Murphy, Michael Ross, Gunnar Heine, Vincent Brandenburg, Sanjeev Sethi, Vivette D'agati, Cynthia Nast, Agnes Fogo, An De Vriese, Glen Markowitz, Richard Glassock, Fernando Fervenza, Surya Seshan, Andrew Rule, Lorraine Racusen, Jai Radhakrishnan, Christopher Winearls, Gerald Appel, Ingeborg Bajema, Anthony Chang, Robert Colvin, H Cook, Sundaram Hariharan, Loren Herrera Hernandez, Neeraja Kambham, Michael Mengel, Karl Nath, Helmut Rennke, Pierre Ronco, Brad Rovin, Mark Haas, Martin Wijkstrom, Hayato Iwase, Wayne Paris, Hidetaka Hara, Mohamed Ezzelarab, David Cooper, Roy Mathew, Sripal Bangalore, Michael Lavelle, Patricia Pellikka, Mandeep Sidhu, William Boden, Arif Asif, Marc Vervloet, Mario Cozzolino, Stefanie Frölich, Patrick Slattery, Dominique Thomas, Itamar Goren, Nerea Ferreiros, Boye Jensen, Rolf Nüsing, Yueh-Lin Wu, Jian Xie, Sung-Wan An, Noelynn Oliver, Nestor Barrezueta, Mei-Hsiang Lin, Lutz Birnbaumer, Chou-Long Huang, Sarah Gabriel, Hendrica Belge, Alkaly Gassama, Huguette Debaix, Alessandro Luciani, Thomas Fehr, Olivier Devuyst, Jorge Giani, Masahiro Eriguchi, Ellen Bernstein, Makoto Katsumata, Xiao Shen, Liang Li, Alicia Mcdonough, Sebastien Fuchs, Kenneth Bernstein, Romer Gonzalez-Villalobos, Monika Wnuk, Manuel Anderegg, Werner Graber, Regula Buergy, Daniel Fuster, Valentin Djonov, Chang Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Choe, Nam Ho, Yang Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-Min Lee, Sun Lee, Jae-Han Jeon, Robert Harris, Keun-Gyu Park, In-Kyu Lee, Sebastian Roeder, Taylor Barnes, Jonathan Lee, India Kato, Diana Eng, Natalya Kaverina, Maria Sunseri, Christoph Daniel, Kerstin Amann, Jeffrey Pippin, Stuart Shankland
Journal: Kidney International (2017)
Relief agencies face crisis of a lifetime
Authors: R. Voelker
Journal: JAMA (1994)

WHEN Jeff Colyer, MD, first met his 16-year-old patient, Veronica, she might have needed a miracle more than a surgeon. The girl had lost a hand and suffered an open skull fracture last June in a machete attack by roving killers near Kibungo, Rwanda, about 65 miles southeast of the capital of Kigali. For 2 weeks, she had been left for dead among 500 bodies piled in a church. By the time Veronica arrived at Kibungo's decimated hospital, she was catatonic and had contracted a severe infection. After a month under Colyer's care, the Kansas City, Mo, volunteer surgeon relayed word back to the United States that Veronica was on the road to recovery. "Today she smiled and told me her name," he wrote in a July 22 letter. "Her wounds are healing." Veronica's miracle and her surgeon materialized thanks to the efforts of the Los Angeles, Calif—based International Medical
Camp for children with cancer a success
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Triiodothyronine Thyrotoxicosis
Authors: G Lande, I Kjolseth
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HUMAN VALUES
Authors: Stewart Wolf
Journal: JAMA (1962)

Much postgraduate education in medicine today is concerned with what might be called medical artisanship. Here the emphasis is on naming, classifying, and prescribing. Here the deep roots of tradition and the strong winds of fashion or of prevailing opinion govern thought and practice. Thus, on looking back over programs of past postgraduate sessions in recent years in any area of the United States, one sees that those who have attended have paid to learn, for example, for the treatment of burns, and the value of pressure bandages, plastic sprays, tannic acid, salt baths, sulfa gels, and, of course, the inevitable ACTH. Today, some postgraduate speakers are urging that burned areas be left alone if they can remain exposed. It is doubtless important to acquaint the practitioner with current opinion, but there may be room for other, perhaps more important, emphases in professional education. William Osler, in the 1903 edition
Real-world comparative economics of a 12-gene assay for prognosis in stage II colon cancer.
Authors: Steven R. Alberts, Tiffany Yu, Robert J. Behrens, Lindsay Anne Renfro, Geetika Srivastava, Gamini S. Soori, Shaker R. Dakhil, Rex Bradford Mowat, J. Phillip Kuebler, George P. Kim, Miroslaw Mazurczak, John C. Hornberger
Journal: Journal of Clinical Oncology (2013)

391 Background: Prior economic analysis of a 12-gene assay (Oncotype DX), compared with patterns of care reported in the NCCN database of patients with stage II, T3, DNA mismatch repair proficient (MMR-P) colon cancer, predicted that the assay would save medical costs and improve patient well-being (Hornberger et al., Value Health, 2012). This study assessed the validity of those findings with actual adjuvant chemotherapy (aCT) recommendations. Methods: Outcomes and costs were estimated for patients with stage II, T3, MMR-P colon cancer using a Markov model. A study of 141 patients from 17 sites in the Mayo Clinic Cancer Research Consortium collected data on aCT recommended before and after knowledge of the 12-gene assay results (Srivastava et al. abstract). Quality-adjusted life years (QALY) and medical resource use after recurrence were computed using guideline-validated state-transition probability estimation methods. Risk of progression and incidence of adverse events with different aCT regimens were based on published literature. Drug and administration costs for aCT were obtained from 2012 Medicare fee schedules. One-way sensitivity analyses were conducted to evaluate parameter influence on economic impact. Results: After receiving the 12-gene assay results, physician recommendations in favor of aCT decreased 22% (95% CI 11%-32%; McNemar test p&lt;0.001) from 73 (52%) to 42 (30%) patients. Oxaliplatin aCT and 5-FU monotherapy recommendations each declined 11%. Average aCT costs decreased $5,738 for drugs, $668 for administration, and $3,268 for adverse events management. Overall, average total direct medical costs decreased $4,203. The net effect on average patient well-being was a gain of 0.083 QALYs. Total medical costs are most influenced by change in aCT recommendations, 5-FU monotherapy efficacy, and oxaliplatin drug acquisition cost. Savings are expected to persist even if the cost of oxaliplatin dropped by &gt;75% due to generic substitution. Conclusions: The 12-gene assayhas been shown to alter aCT recommendations for patients with stage II, T3, MMR-P colon cancer. This study provides real-world confirmation that these changes in aCT reduce direct medical costs and improve patient well-being.
Miscellanea Medica
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: BMJ (1895)

demned in consequence of the animal having suffered from tuberculosis.The number of carcasses seized by medical officers of health and inspectors of nuisances rose from 7,269 in 1894 to 9,823 in 1895.In 1894 526 carcasses, and 1895 318 carcasses were condemned by justices.The number of carcasses so condemned in consequence of the animal having suffered from tuberculosis rose from 132 in 1894 to 147 in 1895.The returns, however, in many cases show that the carcasses were destroyed without being taken before the justices, and that some of the carcasses so destroyed were those of animals which had suffered from tuberculosis.Some local authorities have furnished information as to carcasses voluntarily surrendered by owners and subsequently destroyed, and pieces of meat, not being whole carcasses, which had been seized and condemned.WATERBORNE TYPHOID AT TORONTO.A TYPHOID fever epidemic is threatened in Toronto.Some time ago the water conduits burst, and since that time the city has been without pure water.The effect is now apparent from the returns of the local Board of Health.For the first fifteen days of the present month 77 cases of typhoid fever were reported, against 29 in the whole month of October last year and 27 cases in October, 1893.There are a large number of patients at the different hospitals: At Grace Hospital there are 36, at St. Michael's 22, and at the General 40 cases.HAMPSTEAD AND VACCINATION.
Correction
Journal: BMJ (1947)

recommended in conjunction with treatment along the lines indicated above and with dyes or calamine lotion applied locally.On the hairy forearms the same principles apply.Autogenous vaccines have also been recommended; non- specific shock therapy is often of value, as are whole-blood injections (10 ml.weekly).Histamine-sensitivity Q.-How should I test for histamine-sentsitivity ?How is desensitization effected particularlv in relation to the treatment of Meniere's syndrome in histaminle-senisitive patients ?A.-To test for histamine-sensitivity inject into the skin of the forearm 0.05 ml. of a 1 in 10,000 solution of histamine, calculated in terms of histamine base.Sensitive patients will react with an urticarial weal almost an inch (2.5 cm.) in diameter, having one or more pseudopodia, 1 inch in length, with a surrounding erythema of 2 inches (5 cm.) or more.In the non-sensitive patient the urticarial weal will be about 1/3 inch (0.8 cm.) in diameter, will have either no pseudopodia or at the most very small buds, and the erythema will be about an inch in diameter.If in doubt test again with double the dose a few days later.If no pseudopodia appear, then the case is not histamine-sensitive.Histamine-sensitive patients should be treated with gradually increasing doses of histamine given subcutaneously.The following is a suggested scheme of dosage: starting with a 1 in 10,000 solution, 0.05 ml., 0.1 ml., 0.2 ml., 0.3 ml., and so on up to 0.8 ml.; then with a I in 1,000 solution, 0.1 ml., 0.2 ml., up to 0.8 ml.; then with a 1 in 100 solution, 0.1 ml. and so on up to a maximum dose of 1 mg., or until symptoms of overdose occur, which is not infrequent at a dose of 0.4 to 0.5 mg.The injections are given twice a week until the maximum, or the maximum without symptdms, is reached, after which this dose is maintained weekly for two months (M.Atkinson,
Back pain in an adolescent
Authors: E. M. Weitz
Journal: JAMA (1980)

<h3>To the Editor.—</h3> I have read the letter from F. K. Peterson, Jr, MD (243:1188, 1980), regarding a 15-year-old boy with back pain after exercise. Peterson states the pain was in the right side of the lower back without radiation to the buttock, although there was tenderness opposite the L-4 spinous process on the right and positive straight leg-raising at 70° on the right, with pain referred to the right buttock. The kick on the right side was likewise restricted. I believe findings such as these probably represent irritation of the nerve root on the right, possibly caused by lateral disk protrusion. Irwin M. Siegel, MD, answered that this is due to "low-back strain." I fail to comprehend how an alleged low-back strain can impair straight leg raising and cause the pain to be referred to the buttock. I am in complete agreement with his treatment program. I think, however,
Carcinogen Regulation
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Growing Hispanic Association Serves Increasing Population
Authors: C. Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vaccination Coverage of 2-Year-Old Children—United States, Third Quarter, 1993
Journal: JAMA (1994)

In 1993, the Childhood Immunization Initiative (CII) was instituted to increase vaccination coverage among 2-year-old children to at least 90% by 1996 for four of the five vaccines routinely recommended for children* and to at least 70% for three doses of hepatitis B vaccine (1). To monitor progress toward these goals, national estimates of vaccination coverage are needed. This report presents national estimates of vaccination coverage among 2-year-old children derived from provisional data from the National Health Interview Survey (NHIS) for the third quarter of 1993 and describes the trend in vaccination coverage since 1992, the baseline year.
The AMA, chiropractic, and Judge Getzendanner's injunction
Authors: Richard P. Wunderlin
Journal: JAMA (1988)

<h3>In Reply.</h3> —Dr Pease is correct in stating that the umbellifer on the cover of the Nov 27 issue of<i>JAMA</i>is not<i>D carota</i>(Queen Anne's lace). It is difficult to determine precisely the species illustrated without seeing a specimen or knowing where the photograph was taken, but it appears to be a species of<i>Angelica</i>, perhaps<i>A venenosa</i>of the eastern United States or a related species.