tbuckley/cabot-search huggingface dataset:
Therapia Steroide con Aerosolo in le Maneamento de Patientes con Sever Asthma Bronchial Chronic
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply:
Authors: Geoffrey Nguyen, Paul J. Thuluvath
Journal: Hepatology (2007)

We congratulate Dr. Myers for his reanalysis of the Nationwide Inpatient Sample (NIS) in response to a study we had published in the May 2007 issue of HEPATOLOGY.1 We agree that initial admission to a liver transplant center is an important predictor of liver transplantation not only because of the lack of longitudinal follow-up in the NIS, but because transferring from a facility that is not a transplant center to a liver transplant (LT) center specifically for liver transplant may itself be a barrier to healthcare access. In addition, liver transplant centers are more likely to have hepatologists who can recognize the indications for LT. However, these observations of "LT center" impact on outcomes do not change the overall findings or conclusions of our original study that emphasized the presence of racial differences in LT, not its underlying cause. Nevertheless, these observations do provide insight into the contributing factors for disparities, and clearly showed that disparities between treatment of Hispanics and whites were not as robust as differences between African Africans and whites. With respect to racial differences in use of paracentesis, we believe that costs of the procedures do influence racial disparities. For low-cost procedures, it is probable that we may not observe gross underuse among racial minorities. We are grateful to Dr. Myers for his well-deliberated supplemental analyses and insightful conclusions that provided a platform for these discussions. Geoffrey Nguyen M.D., Ph.D., F.R.C.P.C.*, Paul J. Thuluvath M.B.B.S., M.D., F.R.C.P.*, * Section of Hepatology, The Johns Hopkins University School of Medicine, Baltimore, MD.
<i>NF1</i> Mutations Prevalent but Not Clinically Relevant
Journal: Cancer Discovery (2015)

Whole-exome sequencing of 213 tumor samples shows that NF1 is mutated in 13.1% of melanomas. The gene is usually mutated in tumors that don't carry mutations in BRAF or NRAS, and it may be a cancer driver. However, loss of the gene didn't predict whether RAS activity increased or whether cell lines responded to inhibitors of the MAP kinase pathway, which RAS activates.
Angiographic studies in cardiorespiratory diseases. Special reference to thromboembolism
Authors: J. K. Alexander
Journal: JAMA (1966)

In 47 patients with pulmonary thromboembolism, selective pulmonary arteriograms disclosed complete or incomplete obstructions of various arterial branches, intra-arterial filling defects, decrease in volume of affected lung segments, and changes in caliber of involved arteries. In 76 other patients with a variety of disorders including left ventricular failure, pneumonia, pulmonary tumor, abscess, bulla, fibrosis, or pulmonary emphysema, the pulmonary arteries were patent to the subsegmental level, showing neither filling defects nor obstructive lesions. Selective pulmonary arteriography has proved practical and relatively safe in our hands. We recommend it as a useful means of establishing the presence and extent of pulmonary thromboemboli, and of determining their location.
BETHECHANGE
Authors: S Griffin
Journal: British Journal of Sports Medicine (2015)

Aim Physical inactivity has been identified as the fourth leading risk factor for non-communicable diseases and accounts for over 3 million preventable deaths each year.1 Healthcare professionals have an important role to play in increasing physical activity (PA) levels,2 and should be educated on the matter.3 Methods BeTheChange was a pilot scheme aimed at increase the advocacy of PA as a healthcare tool by targeting both the education and practice of PA among medical students. An educational seminar was attended by 108 delegates (12 medical students). Results Only one felt that sufficient training had been provided on the matter and 100% felt more likely to advocate PA as a healthcare tool following the seminar. Twenty-two medical students attended a local gym using a free BeTheChange pass. Five students correctly identified the Chief Medical Officer (CMO) guidelines,4 but only one felt that sufficient training had been provided. A further four students thought that sufficient teaching was provided, yet were unable to correctly identify the CMO guidelines. Conclusions Despite a low sample size, knowledge of the CMO guidelines was low, and the majority of medical students did not feel as if they had received sufficient teaching on the matter. BeTheChange highlights the need for PA-related teaching in the undergraduate curriculum and warrants further investigation as a novel method of increasing the advocacy of PA among medical students.
Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk
Authors: Lukasz Kiljanek
Journal: Annals of Internal Medicine (2009)

Letters19 May 2009Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular RiskLukasz Kiljanek, MDLukasz Kiljanek, MDFrom PinnacleHealth System, Harrisburg, PA 17101.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-10-200905190-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the article by Paynter and colleagues (1). Is it possible that rs10757274 risk alleles are already associated with ATP III score, elevated CRP level, or family history? This could be the reason why including this genetic marker into prediction did not improve the c-statistic.Lukasz Kiljanek, MDPinnacleHealth SystemHarrisburg, PA 17101Reference1. Paynter NP, Chasman DI, Buring JE, Shiffman D, Cook NR, Ridker PM. Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med. 2009;150:65-72. [PMID: 19153409] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From PinnacleHealth System, Harrisburg, PA 17101.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCardiovascular Disease Risk Prediction With and Without Knowledge of Genetic Variation at Chromosome 9p21.3 Nina P. Paynter , Daniel I. Chasman , Julie E. Buring , Dov Shiffman , Nancy R. Cook , and Paul M. Ridker Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk John R. Schwarzenbach Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk Nina P. Paynter , Nancy R. Cook , and Paul M Ridker Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk Jeff Gulcher and Kari Stefansson Metrics 19 May 2009Volume 150, Issue 10Page: 736KeywordsAdenosine triphosphateAllelesC-reactive proteinsConflicts of interestGenetics ePublished: 19 May 2009 Issue Published: 19 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AASLD Program
Authors: William Balistreri, M Carroll, Hyun Young, Mark Claassen, Maria Longhi
Journal: Hepatology (2007)

Designed for physicians, surgeons, scientists, educators, nurses, physician assistants, and all other hepatology health professionals, The Liver Meeting ® is the premier event in the science and practice of hepatology where the cutting edge in the study and treatment of liver and biliary diseases is defined.The Liver Meeting ® continues its tradition of providing a forum for the exchange of groundbreaking research and clinical information in a variety of formats, including workshops, plenary and parallel sessions, poster sessions, scientific exhibits, and State-of-the-Art Lectures.The majority of events during The Liver Meeting ® will take place in the John B.
CREATINURIA
Authors: J. P. Sedgwick
Journal: JAMA (1918)

<h3>To the Editor:</h3> —In an editorial with this title (The Journal. Dec. 29, 1917, p. 2186), the following appeared: Normal children, however, are now recognized to excrete creatin commonly during the period of adolescence. This was demonstrated in this country several years ago by W. C. Rose at Yale University and verified by Folin and Denis at the Harvard Medical School. A similar statement has appeared a great many times in literature and I am, therefore, sending you herewith a reprint of my article on "Creatinin and Creatin Metabolism in Children" (The Journal, Oct. 1, 1910, p. 1178), which appeared before Rose's article. I would refer also to another reprint on the "Creatinin and Creatin Excretion in Recurrent Vomiting" (<i>Am. Jour. Dis. Child</i>., April, 1912, p. 209). Rose recognizes my work in his own article also.
A Generalized Mantel-Haenszel Analysis of the Regression of Blood Pressure on Blood Lead Using NHANES II Data
Authors: J. Richard Landis, Katherine M. Flegal
Journal: Environmental Health Perspectives (1988)

This paper proposes an alternative analysis of the statistically significant blood pressure/blood lead relationship reported for males, ages 12 to 74, based on data from the second National Health and Nutrition Examination Survey. Because of the substantial decline, both for blood lead levels and blood pressures, during the 4-year survey period, there is considerable interest in the extent to which this association can be attributed to concurrent secular trends. The statistical methods illustrate the use of a randomization model-based approach to testing the statistical significance of the partial correlation between blood lead level and diastolic blood pressure, adjusting for age, body mass index, and the 64 sampling sites. The resulting analyses confirm that the significant linear association between blood lead levels and diastolic blood pressures cannot be dismissed as a spurious association due to concurrent secular trends in the two variables across the 4-year survey period. In a conservative approach to this investigation, a randomization model-based test statistic, using the actual level of the natural log of blood lead and diastolic blood pressure, remained statistically significant at the 5% level, even when averaging the association across 478 subgroups formed by the cross-classification of age, body mass index, and the 64 sampling sites.
Thirty‐one‐year survival following chemotherapy and autologous bone marrow in malignant lymphoma
Authors: Farid I. Haurani
Journal: American Journal of Hematology (1997)

A 21-year-old woman with malignant lymphoma received a large dose of nitrogen mustard followed by autologous bone marrow. She achieved a complete remission that lasted 21 years. This was followed in a span of 10 years by two relapses that responded to chemotherapy and splenectomy. Death resulted from sepsis. At autopsy, there was minimal evidence of malignant lymphoma, but evidence for side effects of chemotherapy was present. Am. J. Hematol. 55:35-38, 1997. © 1997 Wiley-Liss, Inc.
Note from the editors: Eurosurveillance - an authoritative information source on infectious diseases
Authors: Collective Eurosurveillance editorial team
Journal: Eurosurveillance (2015)

Preview this article: Note from the editors: Eurosurveillance - an authoritative information source on infectious diseases, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/20/1/art21005-en-1.gif
Americans studying abroad
Authors: D. D. Goldberg
Journal: JAMA (1975)

IT IS estimated that there are presently 3,715 American-born students who are forced to leave the United States to study medicine in a foreign country, in a foreign tongue.<sup>1(p912)</sup> These students are highly motivated to study medicine. In many cases, they would have gained admission to a US medical school had there been enough places. Many come from affluent families, as do their brothers in US medical schools. Others scrape or borrow to meet the financial obligations to complete their studies. Depending on the school to which they are admitted, students may have to begin their training at the premedical school level, eg, in Italy, France, and Belgium (some schools), or they may receive one year's credit exemption for the premedical work performed during their four-year US bachelor's program. In many cases, they are helped in their admission to French medical schools by commercial entrepreneurs using a "packaged plan"
Abstract 16959: Interleukin-1 Blockade in Acute Decompensated Systolic Heart Failure: Results of the Anakinra in Decompensated Heart Failure Pilot Study
Authors: Benjamin W Van Tassell, Salvatore Carbone, Claudia Oddi Erdle, Nayef Antar Abouzaki, Ryan D Melchior, Jeremy S Turlington, Cory R Trankle, Sanah Christopher, Christopher S Thomas, Daniel T Fronk, Clinton Thurber, Charles A Dinarello, Giuseppe Biondi-Zoccai, Antonio Abbate
Journal: Circulation (2015)

Background: The inflammatory response in acute decompensated heart failure (ADHF) may contribute to the progression of the disease, complication, and re-hospitalization. Interleukin-1 (IL-1) has been identified as a potential therapeutic target in HF. We hypothesized that IL-1 blockade, with Anakinra (Kineret™, Swedish Orphan Biovitrum), would quench the acute inflammatory response in patients with ADHF. Methods: We randomized 30 patients with ADHF, reduced left ventricular ejection fraction (LVEF&lt;40%), and elevated C reactive protein (CRP) levels (≥5 mg/l) to either Anakinra 100 mg twice daily for 3 days followed by once daily for 11 days or matching placebo, in a 1:1 double blinded fashion. We measured CRP and IL-6 plasma levels using high-sensitivity assays, daily for 5 days, and then again at 14 days and evaluated the area-under-the-curve (AUC) and interval change (delta). Results: Treatment with Anakinra was well tolerated: there were 7 adverse events in 6 patients treated with Anakinra and 12 in 10 patients treated with placebo (OR 0.33 [0.08-1.48, P=0.15). Two patients in the Anakinra group and 5 in the placebo group suspended treatment prematurely (OR 0.31 [0.05-1.93], P=0.21). When compared with placebo, Anakinra did not reduce the CRP-AUC at 4 days (primary endpoint) or at 14 days, while it significantly reduced the IL-6-AUC at 4 and 14 days (Table). Two patients in the Anakinra group and 3 patients in the placebo group experienced worsening HF or readmission for HF (OR 0.61 [0.09-4.34], P=0.62). In patients with paired baseline and day 14 echocardiograms (N=14), Anakinra was associated with a greater recovery in LVEF vs placebo (+10% [+3/+14] vs 0 [-16%/+5%], P=0.020, respectively). Conclusions: IL-1 blockade with Anakinra in patients with ADHF appears to be safe and is associated with a blunted inflammatory response. Further studies are warranted to determine whether this anti-inflammatory effect translates into improved clinical outcomes.
Antitumor therapy for congenital skin diseases
Authors: W. A. Check
Journal: JAMA (1979)

The first successful treatment of two severe congenital skin diseases has been reported by Edmund Klein, MD, associate chief of the Department of Dermatology at Roswell Park Memorial Institute, Buffalo. While both diseases are rare, Klein suggests that the method used—administration of extremely low doses of antimitotic agents—may present a new therapeutic approach to proliferative skin diseases, possibly including some forms of cancer. The two genetic diseases are ichythyosis linearis circumflexa (ILC) and poikiloderma congenitale (PC). ILC involves erythematous or "scaly" exfoliations over the whole body surface as does PC. In addition, however, persons with PC have decreased function of apocrine and eccrine glands, reduced pigmentation, telangiectasia leading to angiomas and, in the advanced stages of the disease, ophthalmic and bone problems. The man with ILC received an initial 50-mg dose of cyclophosphamide and three weeks later began to receive 50 mg every three days, which was subsequently reduced to
Chirurgie Vasculaire Conservatrice. Technique — Indications Opératoires et Résultats.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulation of animal experimentation
Authors: T. D. Overcast
Journal: JAMA (1985)

This article examines the nature of the controversy between animal activists and the scientific community over the need for and desirability of additional regulation of animal experimentation. We critically review the existing federal and state regulatory environment and discuss a number of proposals for new federal legislation for regulating the use of animals in scientific experimentation. We identify and discuss three factors that encompass the issues that are at the core of the controversy and use these to suggest a conceptual framework in which to analyze schemes for regulating animal experimentation. Finally, we discuss the implications that such regulation will have for animal experimentation and conclude that it is neither necessary nor desirable. (<i>JAMA</i>1985;254:1944-1949)
Megavitamin therapy
Authors: T. H. Jukes
Journal: JAMA (1975)

VITAMINS are defined as carbon compounds that are needed in small amounts in the diet of animals. Amino acids, proteins, fats, carbohydrates, and minerals are excluded from this definition. Vitamins became known by the deficiency diseases that result from their absence. Such diseases have severe and distinctive signs and symptoms. The discovery, identification, and synthesis of the vitamins lessened the incidence of these diseases, including pellagra, rickets, scurvy, and others, so that they are now rare in the United States. The therapeutic effects of vitamins on deficiency diseases are so spectacular that popular attention has long been captivated by vitamins as components of the daily diet. Foods that are good sources of vitamins often supply other important nutrients such as proteins and minerals. Many people are interested in warding off possible effects of partial or "subacute" vitamin deficiencies by selecting a good diet. Often, they also take pills containing synthetic
Prophylactic Antihistamines
Authors: S. J. Patel
Journal: BMJ (1964)

Until benzidine was taken off the market because of carcinogenic risks to those engaged in its manufacture the test most widely used was the Gregersen slide-test.'It was in general use on the Continent and in America, and was becoming more generally used in this country.It was recommended in many of the textbooks.5In general practice and in hospital side- wards there are obvious objections to tests, such as the test-tube benzidine and ortho- tolidine tests commonly employed in clinical laboratories, which may give positive results with gum-bleeding and after the eating of meats in moderate amount.Ogilvie, who was the first in this country to describe the Gregersen slide-test,8 affirmed that with it a blue or green-blue colour appearing within 30 seconds is proof of the presence of occult blood irrespective of the patient's diet, with the obvious exceptions of foods with a high blood-pigment concentration such as liver, black pudding, and bone-marrow.Now it is recognized that salicylates also should be withheld.Bockus' employs the Gregersen slide-test as a routine procedure.Benzidine is now produced under safe con- ditions of manufacture and is again on the market.Put up in waxed paper the powders will last indefinitely.The Greger- sen slide-test is cheap and simple and can be performed just as quickly as the tablet tests.Its reliability has been widely proved over the years, and it should be finding its way back into our hospital side-rooms and our consulting-rooms.-Iam, etc., Edinburgh 9. S. LIPETZ.
Volume 21, Number 2, August 1958
Journal: JNCI Journal of the National Cancer Institute (1958)

Page 286, footnote 8: In the paper entitled “Effects of Donor and Host Lymphoid and Myeloid Tissue Injections in Lethally X-Irradiated Mice Treated with Rat Bone Marrow,” by Santos and Cole, for “No lysed or lyophilized control was carried out for rat thymus, rat spleen homogenate, lysate, and lyophilizate. All rat thymus homogenate contained bacteria, but no quantitative differences in these preparations were noted when plate cultures were made” read “No lysed or lyophilized control was carried out for rat thymus. Rat spleen homogenate, lysate, lyophilizate, and rat thymus homogenate all contained bacteria, but no quantitative dififerences in these preparations were noted when plate cultures were made.”
Alcoholism in Women
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal