tbuckley/cabot-search huggingface dataset:
Hepatic distribution of E2 component of pyruvate dehydrogenase complex after transplantation
Authors: J NEUBERGER
Journal: Hepatology (1995)

We have examined the distribution of the E2 component of pyruvate dehydrogenase complex in the liver of patients with native primary biliary cirrhosis (PBC), and after transplantation, using affinity-purified anti-E2 antibodies. In the posttransplantation group, we studied biopsy specimens from patients grafted for conditions other than PBC (n = 6) and those grafted for PBC with (n = 6) and without (n = 5) histological features suggestive of PBC recurrence. Features suggestive of PBC recurrence included portal tract granulomas, bile duct damage, ductopenia, and lymphoid aggregates. In the native liver from patients with PBC, there was increased staining of E2 on the biliary epithelial cells compared with hepatocytes, as previously described. However, in liver biopsy specimens from patients after transplantation, the pattern of staining of E2 was similar to that of normal, control liver in all three groups studied. These findings suggest that E2 overexpression on bile duct cells may not be important in the perpetuation of the bile duct damage in PBC, that expression in the allograft may be modified by immunosuppression, or that PBC does not recur in the allograft. (Hepatology 1995; 22:798–801.)
The Truth About Alcohol Dependence
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two Incorrect Author Affiliations
Journal: JAMA (2016)

Lorelei A. Mucci, ScD, MPH; Jacob B. Hjelmborg, PhD; Jennifer R. Harris, PhD; Kamila Czene, PhD; David J. Havelick, ALM; Thomas Scheike, PhD; Rebecca E. Graff, ScD; Klaus Holst, PhD; Sören Möller, PhD; Robert H. Unger, BS; Christina McIntosh, SM; Elizabeth Nuttall, BA; Ingunn Brandt, MSc; Kathryn L. Penney, ScD; Mikael Hartman, MD, PhD; Peter Kraft, PhD; Giovanni Parmigiani, PhD; Kaare Christensen, MD, PhD; Markku Koskenvuo, MD, PhD; Niels V. Holm, MD, PhD; Kauko Heikkilä, PhLic; Eero Pukkala, PhD; Axel Skytthe, PhD; Hans-Olov Adami, MD, PhD; Jaakko Kaprio, MD; for the Nordic Twin Study of Cancer (NorTwinCan) Collaboration
A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
Authors: Christopher B. Newgard, Jie An, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, Lillian F. Lien, Andrea M. Haqq, Svati H. Shah, Michelle Arlotto, Cris A. Slentz, James Rochon, Dianne Gallup, Olga Ilkayeva, Brett R. Wenner, William S. Yancy, Howard Eisenson, Gerald Musante, Richard Surwit, David S. Millington, Mark D. Butler, Laura P. Svetkey
Journal: Cell Metabolism (2009)
Mesquite Grove, Arizona
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Editor's Choice
Journal: British Journal of Dermatology (2013)

Brachioradial pruritusBrachioradial pruritus is a poorly understood condition that has been relatively neglected in the medical literature.Th is study of 111 patients with brachioradial pruritus represents the largest series of patients with this diagnosis reported to date.Th e study was carried out at the Mayo Clinic and involved a retrospective review of clinical notes over a 12-year period.Th is series consisted of 72% female and 28% male patients.In those patients referred to neurologists, structural causes were rarely identifi ed.
Medical School Libraries in the United States 1960 through 1975
Authors: S. Crawford
Journal: JAMA (1977)

FOR ALMOST two decades subsequent to World War II, federal support for science and technology in the United States reached a magnitude never before equalled. Especially during the period 1953 to 1965, there occurred a sharp and sustained increase of huge proportion. While total expenditures by all sectors of the economy increased at an average rate of 13% per year, the contribution of the federal government to science grew at the rate of nearly 20% per year.<sup>1</sup>It was in this period that a great national research program in the health sciences developed, followed by public demand for increasing services in health, education, and welfare. Health sciences libraries, as strategies in attaining the objectives of research, teaching, and health care provision, were in turn affected by increased production of information and began to experience difficult problems in its handling and control. In the early postwar period, they were still
Mental Hygiene and the Public Health Nurse. Practical Suggestions for the Nurse of Today.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Permanent Membership by Application.
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORRECTION OF CICATRICIAL ECTROPION BY USE OF TRUE SKIN OF UPPER LID
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does tobacco advertising target young people to start smoking? Evidence from California
Authors: J. P. Pierce
Journal: JAMA (1991)

<h3>Objective.</h3> —To evaluate whether tobacco advertising encourages teenagers younger than 18 years to start smoking. <h3>Design.</h3> —Comparison of 1990 California telephone survey data with data from a 1986 national telephone survey (both used a random-digit dialing system); 95% confidence intervals were calculated. To test our hypothesis, we considered whether the perception of advertising was related to age, whether the pattern of market share across age and sex groups followed the pattern of perceived advertising, and whether changes in market share paralleled changes in advertising as perceived by the youngest age group. <h3>Participants.</h3> —There were 24296 adults and 5040 teenagers. <h3>Results.</h3> —The most advertised brands of cigarettes were Marlboro, according to 33.6% of adults and 41.8% of teenagers, and Camel, according to 13.7% of adults and 28.5% of teenagers—named most often by 12- to 13-year-olds (34.2%). The brands that were purchased most often were Marlboro and Camel. Together these were the brands of choice of 79.9% of males and 85% of females aged 12 through 17 years. Marlboro's market share increased in youths and young adults up to age 24 years and then decreased gradually with age; Camel's market share decreased abruptly with age: it was the brand of choice of 24.5%±5.8% of males aged 12 through 17 years but was chosen by only 12.7%±3.6% of males aged 18 through 24 years; for females, 21.7%±13.7% aged 12 through 17 years chose Camels, while only 5.5%±3.2% aged 18 through 24 years preferred this brand. Both Marlboro and Camel brands had a higher market share in California in 1990 compared with that for the United States in 1986. Of interest is that the market share for Camel increased among the younger smokers but was more evenly distributed for Marlboro. <h3>Conclusions.</h3> —Perception of advertising is higher among young smokers; market-share patterns across age and sex groups follow the perceived advertising patterns; and changes in market share resulting from advertising occur mainly in younger smokers. Cigarette advertising encourages youth to smoke and should be banned. (<i>JAMA</i>. 1991;266:3154-3158)
Error in Author Surname in Affiliations and Author Contributions
Journal: JAMA Network Open (2020)

Zhi Wei Lim, BSc (Hons); Miao-Li Chee, BSc; Zhi Da Soh, MPH; Ning Cheung, MD; Wei Dai, MD, MPH; Thakur Sahil, MBBS; Yijin Tao, MD; Shivani Majithia, OD; Charumathi Sabanayagam, MD, PhD; Christopher Li-Hsian Chen, BMBCh; Tien Yin Wong, MD, PhD; Ching-Yu Cheng, MD, PhD; Yih-Chung Tham, PhD
Distinguishing primary and metastatic carcinomas of the liver: Immunohistochemical updates and reminders
Authors: N Theise
Journal: Hepatology (1994)

Distinguishing primary hepatocellular carcinoma (HCC) from metastatic carcinomas to the liver is often difficult, if not impossible, particularly in needle biopsy and fine-needle aspiration specimens. In an attempt to identify a specific immunohistochemical profile that would distinguish HCC from metastatic carcinomas, we studied 56 HCCs, 8 cholangio-carcinomas, and 24 metastatic adenocarcinomas with monoclonal antibodies to alpha-fetoprotein (AFP), keratin (AE1, AE3, and CAM5.2), Leu-M1, human milk fat globule (HMFG-2), tumor-associated glycoprotein-72 (B72.3), epithelial specific membrane antigen (Ber-EP4), and BCA-225 (CU-18). Both monoclonal and polyclonal (mCEA and pCEA) antibodies to carcinoembryonic antigen also were used. Metastatic adenocarcinomas were often positive for CU-18 (71%), Leu-M1 (75%), B72.3 (50%), HMFG-2 (67%), Ber-EP4 (83%) and mCEA (71%). Using these antibodies, the frequency of positivity for HCC was 9%, 16%, 11%, 20%, 36%, and 11%, respectively. CU-18 was the only monoclonal antibody in which there was a significant difference in positive rates between HCC and metastatic adenocarcinomas. Most HCCs (71%) revealed a bile canalicular staining pattern with pCEA. Because this staining pattern was absent in metastatic carcinomas, pCEA appears to be useful in confirming a diagnosis of HCC, AE1, AE3 and CAM5.2 antibodies were not useful in distinguishing HCC from metastatic carcinomas. Each cholangiocarcinoma shared a staining profile similar to that of metastatic carcinomas. Hepatocyte paraffin 1 is a monoclonal antibody that has been developed specifically to react with hepatocytes in routine formalin-fixed and paraffin-embedded surgical pathology tissues. It results in a distinct, granular cytoplasmic staining of hepatocytes but fails to react with bile ducts and nonparenchymal liver cells. The antibody decorates a majority of hepatocellular carcinomas, including fibrolamellar variants. It fails to react with a wide variety of other adult malignancies, with the exception of focal staining in a few gastrointestinal malignancies, including a sub-population of gastric carcinomas.
Gastroesophageal Reflux Disease and Barrett’s Esophagus
Authors: T Rösch
Journal: Endoscopy (2001)

This year’s Digestive Disease Week (DDW) once again saw a large number of abstracts on gastroesophageal reflux disease (GERD) and Barrett’s esophagus (BE), with a special emphasis on diagnostic aspects using magnification endoscopy and on the new antireflux therapies. This review focuses on highlights from these abstracts.
Health care unreform. The New Jersey approach
Authors: J. C. Cantor
Journal: JAMA (1993)

INTEREST in health care reform at the level of the states is greater now than ever. Unprecedented numbers of states are giving serious study and beginning implementation of bold new approaches to health care financing.<sup>1,2</sup>Some proposed state reforms are comprehensive, such as those under development in Colorado, Oregon, Vermont, and Washington. Others take substantial incremental steps, including those in Minnesota, New York, and Florida. One other state, New Jersey, took action to change its financing system with lightning speed. New Jersey was thrust into the forefront of health care reform when, in May 1992, a federal judge overturned that state's long-standing program of financing hospital care for the indigent. By November 30, 1992, the state government had designed and adopted a sweeping change of its hospital financing system. The federal court decision was based on a suit brought by labor unions challenging whether the state was permitted to
THERAPEUTIC DECADENCE IN BRITAIN.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cognitive Rehabilitation Aims to Improve or Replace Memory Functions in Survivors of Head Injury
Authors: Timothy F. Kirn
Journal: JAMA (1987)

WHERE MEDICINE leaves off in the treatment of the growing number of head-injury survivors, cognitive rehabilitation picks up. Many cognitive rehabilitation specialists say that because the field is in its infancy, no one is yet sure how much it can achieve or how many can be helped. Most of the specific methods still need to be evaluated, they add. Some neurologists tend to have what they call a "healthy" skepticism of both the theories and many of the programs. But recent work suggests that it may help a few head-injured persons—who otherwise might spend their days frustrated and making no progress, totally reliant on institutions and loved ones— return to functional, if not productive, lives. Motor vehicle accidents cause far and away the majority of severe head and/or brain injuries. Not surprisingly, two thirds of victims are young males, 15 to 25 years of age. The typical scenario, according to
A memorable patient: How life events change patients' perspectives of their conditions
Journal: BMJ (2004)

Questions such as how clinicians can be patient centred in email consultations require innovative approaches to researching consultations that place emphasis on semantics (as written words are the sole conveyors of information).Because of the intricate ways in which email combines human communication and information communication technology, interdisciplinary research is essential.We know that a large part of a verbal message's impact derives from the communication style and the clinician's "image" and appearance rather than the content.Will the user interface and the application's functionality (that is, the program design and layout) take this role in email consultations and become a critical element in the human-computer-human interaction?Examples of questions about interface design include, "Should different interfaces be used for different populations considering factors such as age, preferred language, and (computer) literacy?"As email consulting increases, we need to ensure that those without email access to care are not unduly disadvantaged (see fig 2 and box 2).Mechanisms for ensuring equitable access to care for sections of the population who do not use email are essential. ConclusionsHealthcare systems are evolving throughout the world and are now embracing the concepts of patientclinician partnership and patient self-management.In this context, email consultations provide exciting possibilities to augment and facilitate healthcare delivery.
The Will to Live
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annual Smoking-Attributable Mortality, Years of Potential Life Lost, and Productivity Losses—United States, 1997-2001
Journal: JAMA (2005)

Smoking harms nearly every organ of the body, causing many diseases and reducing quality of life and life expectancy. This report assesses the health consequences and productivity losses attributable to smoking in the United States during 1997-2001. CDC calculated national estimates of annual smoking-attributable mortality (SAM), years of potential life lost (YPLL) for adults and infants, and productivity losses for adults. The findings indicated that, during 1997-2001, cigarette smoking and exposure to tobacco smoke resulted in approximately 438,000 premature deaths in the United States, 5.5 million YPLL, and 92 billion dollars in productivity losses annually. Implementation of comprehensive tobacco-control programs as recommended by CDC can reduce smoking prevalence and related mortality and health-care costs.