tbuckley/cabot-search huggingface dataset:
Diagnosis and treatment of fat embolism
Authors: C. M. Evarts
Journal: JAMA (1965)

The occurrence of fat embolism as a complication of skeletal trauma has been of interest for more than a century. The controversy in regard to the source of the embolic fat has still not been resolved. The incidence of fat embolism is relatively high both on the battlefield and in civilian life (Table 1).<sup>1-7</sup>The severity of this complication in association with multiple injuries, especially with fractures of long bones, is not generally appreciated. Systemic fat embolism produces a clinical syndrome with characteristic findings and pertinent laboratory results. With a better understanding of the underlying pathophysiological mechanisms, treatment has become more specific and less empirical. <h3>Pathogenesis</h3> The pathogenesis of fat embolism is still subject to conjecture and controversy. The genesis of the embolic fat is postulated as being either mechanical or physiochemical. Although it is possible that intravasation of fat into vascular channels can occur after trauma, recent studies<sup>8</sup>
Exhibit explores link between art and epilepsy
Authors: P. Cotton
Journal: JAMA (1994)

ELECTRICAL STORMS in the cortex, known to science as temporal lobe epilepsy (TLE), sometimes bring cognitive rains that nurture art. Perhaps it is not surprising that such a phenomenon in the part of the brain thought to be the seat of conscious awareness would have an impact on creativity. The functions of this part of the brain include vision, emotion, movement, sensation, hearing, spatial perception, and "everything else that we consciously experience day in and day out," says Steven C. Schachter, MD, an assistant professor of neurology at Harvard Medical School and senior neurologist at Beth Israel Hospital, Boston, Mass. He is also president of the Massachusetts chapter of the Epilepsy Foundation. The relationship between art and epilepsy, between seizure and creativity, is explored in an exhibit called "From the Storm: Artists With Temporal Lobe Epilepsy." It includes works from more than two dozen artists with TLE, painters, sculptors, poets,
Correction
Journal: Circulation (2008)

an error occurred.In Table 2, row 16, the values for "Death, MI, or stroke" were inadvertently omitted.These values, moving left to right, are "1649 (12.8)" [n (%) for heparin], "14898 (11.5)" [n (%) for fondaparinux], "0.90" [HR], 0.84 -0.96 [95% CI], and "0.002" [P].
Basal values and on treatment decline of hepatitis B core-related antigen are predictive of response to interferon therapy in chronic hepatitis D
Authors: A. Olivero, G.P. Caviglia, A. Ciancio, C. Bosco, R. Fontana, G. Niro, M. Rizzetto, G. Maria Saracco, A. Smedile
Journal: Journal of Hepatology (2018)
Contributions to a New Chapter in the Physiology and Pathology of the Nervous System
Authors: T. Laycock
Journal: BMJ (1868)

XSS.TAM BRIShF MfED CAL 7OURWAL.s15 and sy that they ol difer in the atcks beig multiple, and in the ancsms ad wb they o .Neiiher of these features seem to me to establish any material distinction between the two classes.Multiple attacks ae, we well know, met with every now and then in cronsc epilepsy.As to,the attendat and originating circumstances, chen the iblC result s so simila, it seems to me very much like ng the uestion at ine, to afirm that the condition of brain they prbdce is ulike that which preils in all cases of essential epilepsy.It is fully onmceded that, among the case of epilepsy occurring in our large tows;, it israre to meet withoue where the morbid condition is not one of anamia and weakness and undue mobility, rather than of sthenic excitement and plethora; yet I can by no means admit that the latter condition is to be tcluded from our list of causes, and I believe the case I narrated at the beginning of this lecture to afford a fair in- stance in point: To the above evidence must be added that of Schrceder ran der Kolk to whom we are much indebted for his minute examina- tion into the changes produced in the nervous centres by this disease.
THE AMERICAN ASSOCIATION OF OBSTETRICIANS AND GYNECOLOGISTS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hope
Authors: Howard Brody
Journal: JAMA (1981)

THOSE of us who talk about ethical issues in medicine have our spiel on "truth-telling" down pat. We talk about the historical background of the policy of benign deception<sup>1</sup>; about data that show that patients generally suspect the truth anyway<sup>2</sup>; about recent changes in physician behavior in the direction of complete disclosure of unwelcome diagnostic news<sup>3</sup>; and finally, about the important ethical principles of autonomy and individual selfdetermination.<sup>4,5</sup>But sooner or later comes the rejoinder, delivered with the air of laying down the trump card: "All of that sounds very good. But how can you possibly justify ever taking away the patient's hope?" In debates on medical ethics, this question is all too often left unanswered. I believe that there is a satisfactory answer and that it has more to do, as Norman Cousins very correctly pointed out, with the "art of medicine" rather than the
Dermoid Cysts
Authors: Bentley P. Colcock, Robert E. Sass, Leonard Staudinger
Journal: New England Journal of Medicine (1955)

ALTHOUGH dermoid cysts are not common and ■ are seldom malignant, they are of interest from several points of view. When they occur near the body surface they are of concern to the patient because of their conspicuousness or because of his fear of cancer. They are of interest to th- surgeon1 2 3 from the standpoint of differential diagnosis and complete surgical removal of the lesion. Dermoid cysts of the ovary in particular are subject to a number of complications that may make surgical intervention urgent.This paper deals with 146 dermoids of the entire body seen at the Lahey Clinic . . .
Differentiation of Mammary Stem Cells In Vivo and In Vitro
Authors: Roger Barraclough, Philip S. Rudland
Journal: Environmental Health Perspectives (1989)

The fully differentiated cells of the rat mammary parenchyma, the ductal epithelial, alveolar, and myoepithelial cells, are distinguished by their ultrastructure and by their accumulation of immunocytochemically detectable marker proteins. The different cell types probably develop from primative ductal structures called terminal end buds, which are present in the developing rat mammary glands, and these structures contain relatively undifferentiated cells. Clonal epithelial stem cell lines, obtained from normal rat mammary glands or benign mammary tumors, differentiate under appropriate conditions along a pathway to droplet-cell/doming cultures of primative alveolarlike cells. Under different culture conditions, the epithelial stem cells differentiate along a separate pathway to myoepitheliallike cells. They accumulate some of the specific marker proteins of myoepithelial cells in vivo, including type IV collagen, laminin, and Thy-1 antigen. In addition, these myoepitheliallike cells in culture contain an abundance of a potential calcium-binding protein, p9Ka, which also occurs in myoepithelial cells of histological sections from mammary glands. The accumulation of type IV collagen, laminin, Thy-1, and p9Ka occurs asynchronously along the pathway to the myoepitheliallike cells in vitro. Furthermore, the steady-state levels of these different marker proteins arise by alterations in the controls at the transcriptional, the posttranscriptional processing, and the translational stages of their production. These results suggest a stepwise control of synthesis of myoepithelial cell marker proteins, and in the case of p9Ka and Thy-1 antigen, this altered control may arise through their possession of novel transcriptional promoters.
ERRATUM
Authors: Soonmyung Paik, Gong Tang, Steven Shak, Chungyeul Kim, Joffre Baker, Wanseop Kim, Maureen Cronin, Frederick Baehner, Christoph Thussbas, Jorg Nahrig, Sylvia Streit, Johannes Bange, Monika Kriner, Nikos Xenidis, Maria Perraki, Maria Kafousi, Stella Apostolaki, Irene Bolonaki, Aliki Stathopoulou, Kostas Kalbakis, Nikos Androulakis, Charalambos Kouroussis, Thanos Pallis, Daniel Lin, Ilsa Coleman, Sarah Hawley, Ruth Dumpit, David Gifford, Daniel Haller, Frederic Reu, Soo Bae, Leonid Cherkassky, Douglas Leaman, Xifeng Wu, Jian Gu, Tsung-Teh Wu, Stephen Swisher, Zhongxin Liao, Arlene Correa, Jun Liu, Carol Etzel, Christopher Amos
Journal: Journal of Clinical Oncology (2006)

second paragraph was given as, "On the other hand, Fc␥R2A-V158 (valine) has higher affinity than Fc␥R3A-F158 (phenylalanine) for human IgG1."While it should have read, "On the other hand, Fc␥R3A-V158 (valine) has higher affinity than Fc␥R3A-F158 (phenylalanine) for human IgG1."
Developmental Care for Very Low-Birth-Weight Infants
Authors: Jeffery S. Garland
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I read with interest the work by Dr Als and colleagues.<sup>1</sup>Although they address a few limitations of their trial, I do not feel that all limitations were adequately covered. My first concern is that we are never told when this randomized trial was conducted. If this randomized trial was conducted prior to the widespread use of surfactant at Joint Program in Neonatology (JPN) nurseries, as suggested in the Editorial,<sup>2</sup>then I assume it occurred anywhere from 1984 to October 1989 when surfactant became available in JPN nurseries.<sup>3</sup>Since the time of the study, management of infants with severe respiratory distress syndrome has changed considerably at JPN and other nurseries. Randomized trials conducted prior to these changes may not provide information that is generalizable to 1994 nurseries. A second concern is with assessment of illness severity at enrollment. Although groups were statistically similar for
A spastic paraplegia mouse model reveals REEP1-dependent ER shaping
Authors: Christian Beetz, Nicole Koch, Mukhran Khundadze, Geraldine Zimmer, Sandor Nietzsche, Nicole Hertel, Antje-Kathrin Huebner, Rizwan Mumtaz, Michaela Schweizer, Elisabeth Dirren, Kathrin N. Karle, Andrey Irintchev, Victoria Alvarez, Christoph Redies, Martin Westermann, Ingo Kurth, Thomas Deufel, Michael M. Kessels, Britta Qualmann, Christian A. Hübner
Journal: Journal of Clinical Investigation (2014)
Lithium in psychiatric disorders.
Journal: BMJ (1968)

MEDIALIJOURNAL 271 and, though fresh heparinized blood is ideal, citrated blood can certainly be given for a limited number of exchanges.Plasmaphoresis has also been recommended," the patient's packed red cells being returned to him in fresh, frozen plasma from a donor, but in practice this may be more difficult to carry out than a simple exchange.But compared with extra- corporeal perfusion of patient's blood through a pig liver1 or cross-circulation with a human volunteer,'6 the other methods available for temporary liver support, it is a relatively simple procedure. Bacteriological Hazards of Beards"After many years of absence from the laboratory scene, beards are now being worn by some persons working with pathogenic micro-organisms."So say M. S. Barbeito and colleagues, of the Industrial Health and Safety Office, Fort Detrick,
Essentials of Approved Residencies
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tropical sprue in upstate New York
Authors: J. S. Davis
Journal: JAMA (1970)

A 17-year-old, upstate New York, high school student was found, on his return from two months spent in India, to have tropical sprue. With oral administration of tetracycline and folic acid, clinical, laboratory, and histologic response was rapid and essentially complete within three months. Such a diagnosis should be considered when natives of temperate climates return from visiting or residing in the tropics with diarrhea, weight loss, or other symptoms suggestive of a malabsorption syndrome.
Editorial Board
Authors: George Bartley, Stephen Mcleod, San Francisco, Henry Jampel, Anita Agarwal, T Iqbal, Ike Ahmed, Jayakrishna Ambati, Tin Aung, Singapore Bengtsson, James Brandt, Wiley Chambers, Balwantray Chauhan, Emily Chew, Michael Chiang, Daniel Albert, Mary Cotch, Helen Danesh-Meyer, Marjan Farid, Steven Gedde, Lynn Gordon, Los Angeles, Mingguang He, Bennie Jeng, Tianjing Li, Sue Lightman
Journal: Ophthalmology (2016)
Renal Vein Ligation
Authors: George M. Weisz
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Summarizing his anatomical study on the pararenal venous system, Anson in 1947 wrote: The left renal vein is found to be situated at the core of an impressive set of venous plexuses and veins: inferior phrenic and suprarenal tributaries enter from above; from below and to the side come spermatic (or ovarian), capsular, lumbar, and ascending lumbar veins, and the anomalous vena cava. Additionally, communication is made with azygos and hemiazygos veins (usually through lumbars) and with the extensive set of internal and external plexuses by way of intervertebral and lumbar veins. These findings were proved further by cadaveric studies, with surgical applications by Erlik et al in 1962 (as cited above). Their final 1965 results, employing urinary output and urine specific gravity measurements, study of electrolytes, use of excretory urography, differential phenolsulfonphthalein studies, and radioactive kidney scans, showed that: "Ligation and even complete section of the
The Authors Reply:
Authors: Takahiro Kuragano, Osamu Matsumura, Akihiko Matsuda, Taiga Hara, Hideyasu Kiyomoto, Toshiaki Murata, Kenichiro Kitamura, Shouichi Fujimoto, Hiroki Hase, Nobuhiko Joki, Atushi Fukatsu, Toru Inoue, Yukihiro Itakura, Takeshi Nakanishi
Journal: Kidney International (2015)
History, Culture
Authors: William C. Summers
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notice.—
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Morphological Changes of Heart Muscle Caused by Successive Perfusion with Calcium-free and Calcium-containing Solutions (Calcium Paradox)
Authors: A. N. E. Zimmerman, W. Daems, W. C. Hulsmann, J. Snijder, E. Wisse, D. Durrer
Journal: Cardiovascular Research (1967)

Perfusion of isolated rat hearts with a modified Tyrode solution followed by perfusion with a calcium-free perfusate results in an electromechanical dissociation and causes no significant morphological changes. However, reinstitution of calcium ions leads to gross morphological changes, as shown by histological and electron-microscopical evidence. Contractility is not restored and electrical activity disappears (calcium paradox). Some of the cells are reduced to empty spaces containing swollen mitochondria. Other cells appear to be intact, but show signs of hypercontraction. Cardiac damage due to the calcium paradox could also be demonstrated by x-ray angiography.
Geriatric Medicine
Authors: Mark D. Heuser
Journal: JAMA (1994)

The maintenance of optimal function and independence in old age is the maxim of geriatric medicine. As the number of elderly individuals increases, so will the prevalence of chronic disease, disability, and dependency. However, recent medical literature is replete with evidence that lifestyle and medical choices made early in life can have a profound effect on the prevalence and severity of disability and chronic disease in the geriatric population. Thus, to decrease the level of disability in elderly persons, physicians must focus attention on lifestyle choices made by younger adults today. The collective long-term goal for pediatric and adult patients might be to achieve a healthy, productive older age. This is the tenet for the practice of "preventive gerontology."<sup>1</sup> A healthy old age, as articulated by Fries<sup>2</sup>in 1980, results from "the compression of morbidity" in which disease and disability are prevented or postponed until near the end
Alveolar soft-part sarcoma
Authors: P. H. Lieberman
Journal: JAMA (1966)

Fifty-three cases of alveolar soft-part sarcoma were analyzed. Forty-six cases were followed long enough to permit collection of survival data by actuarial methods: 82.8% (±5.9%) in two years, 59% (±8.8%) in five years, and 47.1% (±9.3%) in ten years. Most tumors were noted in female patients and there seemed to be a trend toward right-sided laterality. Tumors developed in female patients at an earlier age than in male patients. The histogenesis of the tumor remains uncertain. The paucity of information and the sluggishness of tumor growth make interpretation of therapeutic effects difficult.
<i>Circulation: Cardiovascular Imaging</i> Editors' Picks
Authors: The Editors
Journal: Circulation (2011)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the “Editors' Picks” for each issue of Circulation: Cardiovascular Imaging published in 2009 and 2010.
Exercise Myoglobinuria
Authors: M. C. KOSHY
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 November 1972Exercise MyoglobinuriaM. C. KOSHY, M.D., DONALD SILVERMAN, M.D., JAMES M. GRANT, M.D.M. C. KOSHY, M.D.Search for more papers by this author, DONALD SILVERMAN, M.D.Search for more papers by this author, JAMES M. GRANT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-5-817_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A case of exercise-induced myoglobinuria reported by Robert W. Hamilton and associates (77:77-82, 1972) prompts us to report a similar case of our own.A 25-year-old white man was admitted to St. Vincent's Hospital, Bridgeport, with rhabdomyolysis. He rapidly developed respiratory paralysis and acute renal failure. There were no apparent precipitating causes except a probable attack of viral respiratory infection (1). However, a year ago he was treated here for rhabdomyolysis after muscular exercise in a football game, but without renal tubular necrosis or other complications.The laboratory data included persistent hyperkalemia, which required K+ free peritoneal...Reference1. SIMONROVNERBERLIN NRB: Acute myoglobinuria associated with type A2 (Hong Kong) influenza. JAMA 212: 1704-1705, 1970 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. C. KOSHY, M.D.; DONALD SILVERMAN, M.D.; JAMES M. GRANT, M.D.Affiliations: Bridgeport Hospital 267 Grant Street Bridgeport, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRhabdomyolysis And Myoglobinuria in ChildhoodExercise Myoglobinuria 1 November 1972Volume 77, Issue 5Page: 817-818KeywordsAcute renal failureExerciseGamesNecrosisParalysisResearch laboratoriesRhabdomyolysisUpper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 November 1972 PDF downloadLoading ...