tbuckley/cabot-search huggingface dataset:
Injuries to the medial meniscus in the aging patient
Authors: H. M. Litchman
Journal: JAMA (1966)

TRAUMATIC internal derangement of the knee is generally associated with the young male athlete or laborer. It has long been felt that this condition was not prone to occur in the aging and that symptoms in the older patient were invariably due to the simultaneous presence of osteoarthritic changes, generally demonstrable by x-ray when these patients appear for evaluation. Furthermore, many orthopedic surgeons, suspecting traumatic derangements in aging patients, have denied them surgical treatment with the opinion that the results were unpredictable and the morbidity high. Recently, it has been emphasized that the elderly patient can also have attritional meniscus ruptures secondary to the osteoarthritis with typical signs and symptoms of derangement.<sup>1</sup> It is the authors' purpose to illustrate that traumatic internal derangements of the knee are not uncommon in the aging, are clinically similar to derangements found in younger patients, and with minor modifications in surgical technique, can
Splinting vs Surgery for Carpal Tunnel Syndrome
Authors: Michael I. Weintraub
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In This Issue
Journal: Journal of Clinical Investigation (2009)

New gene linked to muscular dystrophy and lipodystrophyOne cause of autosomal-dominant limb-girdle muscular dystrophy is an inherited deficiency in caveolin-3 (CAV3).Caveolin proteins are the main protein components of caveolae, plasma membrane invaginations involved in many cellular processes, although other proteins (including polymerase I and transcript release factor [PTRF]) are thought to be important for caveolae formation and caveolin stabilization.In this issue, Hayashi and colleagues report that five nonconsanguineous Japanese patients with generalized lipodystrophy and muscular dystrophy, whose muscles showed CAV-3 deficiency but no CAV3 mutations, had PTRF gene mutations (2623-2633).Two frame-shift mutations were identified in the five patients, and when the resulting mutant forms of PTRF were expressed in mouse myoblasts, the mutant proteins failed to localize correctly and associate with caveolin proteins.Functionally, this probably causes the reduction in caveolae density observed in biopsied skeletal muscle from the patients.The authors therefore conclude that PTRF is crucial for caveolae formation and proper caveolin localization and that disease in the five patients assessed in the study is likely to be a result of caveolin deficiencies secondary to the PTRF gene mutations.
Abstract 1050: Characterization of human cancer cell line xenografts in humanized mice
Authors: Christina Stevens, Christopher Maddage, Kerri Lasky, Jonathan Rios-Doria, Holly Koblish
Journal: Cancer Research (2019)

Abstract Studying immune-oncology (IO) agents that target the human immune system in mice have posed challenges for oncology researchers. Since the commercial introduction of humanized mice, antitumor efficacy studies can now be performed with human cancer cells within mice bearing the components of a human immune system. However, development and characterization of these models is necessary to understand which model may be best for different agents. To this end, we characterized A375, A549, Caki-1, H1299, H1975, HCC827, HCT116, KU19-19, MDA-MB-231, and RKO human cancer cell lines in CD34+ humanized NSG mice for tumor growth rate and immune cell profiling in tumor and spleen compartments. We found that CD4+ T cell composition in both the spleen and tumor varied among the models, with A375, Caki-1, and RKO expressing higher levels of CD4+ T cells compared to the other models. Many of the models had moderate levels of CD8+ T cells in the tumor. Spleen analysis revealed higher NK cell populations in mice bearing Caki-1 tumors, while A549 tumor samples had a higher percentage of NK cells relative to the other models. Surprisingly, many of the tumor models showed an abundance of myeloid cells in the spleen and tumor compartments, although these were mostly comprised of B cells and dendritic cells and lower levels of macrophages and MDSCs. The expression level and percentage of cells expressing PD-1, and PD-L1 in the models were also determined. Furthermore, the antitumor response of select models to PD-1 and PD-L1 antibodies will be presented. In summary, these data demonstrate that there are tumor-intrinsic factors that influence the immune cell repertoire within tumors and spleen. These data may also aid in selection of tumor models to test antitumor activity of novel IO agents. Citation Format: Christina Stevens, Christopher Maddage, Kerri Lasky, Jonathan Rios-Doria, Holly Koblish. Characterization of human cancer cell line xenografts in humanized mice [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1050.
Prospects in Psychiatric Research
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oil Wells in the Woods.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ophthalmology
Authors: Leonard A. Levin
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Erratum:</i> Vol. 68, No. 39
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

In the report "Characteristics of a Multistate Outbreak of Lung Injury Associated with E-cigarette Use, or Vaping -United States, 2019," on page 860, in the first paragraph, the ninth sentence should have read "Among 514 patients with information on substances used in e-cigarettes, or vaping products, in the 3 months preceding symptom onset, 76.9% reported using THC-containing products, and 56.8% reported using nicotine-containing products; 36.0%reported exclusive use of THC-containing products, and 16.0% reported exclusive use of nicotine-containing products."Also on page 860, in the last paragraph, the third sentence should have read "Among a subset of 514 patients (63.8%) for whom information on substances used in e-cigarettes, or vaping, products was available, 395 (76.9%) reported using THC-containing products, and 292 (56.8%) reported using nicotine-containing products in the 3 months preceding symptom onset; 210 patients (40.9%) reported using both THCcontaining and nicotine-containing products, 185 (36.0%) reported exclusive use of THC-containing products, and 82 (16.0%) reported exclusive use of nicotine-containing products."
Abstract 305: Cxcr6 Aggravates Myocardial Ischemia/reperfusion Injury Through Inducing Il-17a Producing Nkt Cells
Authors: Shi-Jun Wang, Jian Wu, Gang Zhao, Jia-yuan Huang, Guoliang Jiang, Yunzeng Zou, Junbo Ge
Journal: Circulation Research (2017)

Objective: Immune inflammation is highly associated with myocardial ischemia/reperfusion (I/R) injury. Invariant natural killer T (iNKT) cells are important participants in early-stage innate immune responses. However their roles in I/R-induced cardiac injury are not well defined. We previously showed that chemokine receptor, CXCR6 deficiency prevented heart from I/R injury through reducing cardiac infiltration of inflammatory cells. In this study, we further analyze the role of CXCR6 in activating iNKT cells and iNKT cells-mediated cardiac dysfunction in response to I/R injury. Approach and Results: After creation of cardiac I/R injury, the mobilization of iNKT cells in thymus gland, spleen and heart were measured by flow cytometry. Loss of CXCR6 significantly attenuated the cardiac infiltration of iNKT cells, but not affected the recruitment of iNKT cells in thymus gland and spleen. This phenomenon did not change even in the case of intravenous injection with α-galactosylceramide (α-GC), the activator of iNKT cells. Also, Index of Infarct size(IFS)/left ventricular (LV) and IFS/area at risk (AAR), measured by image analyzer after TTC staining, were both lower in CXCR6-/- mice than in wild-type(WT) mice. M-mode echocardiography showed that left ventricular ejection fraction (LVEF) was significantly increased in CXCR6-/- mice when compared with that in WT control mice. In addition, autophagy-related proteins, Beclin-1 and ATG5 were upregulated, and p62 was downregulated in the early stage of reperfusion in CXCR6-/- mice. In vitro, IL-17a secretion was significantly increased in spleen-derived iNKT cells after inducing by α-GC, but α-GC stimulation failed to enhance IL-17a production in CXCR6-/- iNKT cells. Further experiment revealed that I/R-induced protein levels of Beclin-1, ATG5 and p62 were all reversed in CXCR6-/- mice with the pretreatment of recombinant mouse IL-17a, whereas the autophagic flux was improved in WT mice after using anti-IL-17a blocking antibody. Conclusions: Our findings highlight CXCR6 as a key chemokine receptor that regulates iNKT cells maturation and cardiac infiltration, which promotes I/R-induced myocardial injury and dysfunction via increasing IL-17a secretion and IL-17a-dependent autophagy inhibition.
Daniel Turner (1667-1740), dermatologist, surgeon, physician
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Antibiotics; Series A, Tokyo
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypothermia-Related Deaths—New Mexico, October 1993-March 1994
Journal: JAMA (1996)

Hypothermia is an unintentional lowering of the body temperature to < or = 95 F (< or = 35 C) (1). From 1979 through 1992, 10,550 persons in the United States died from hypothermia, an average of 754 deaths per year (range: 557-1021). Most of these deaths occurred during winter months in three distinct climatic areas: northern states characterized by moderate to severe cold temperatures during winter (e.g., Illinois and New York); southern states where rapid changes in temperature occur because of the effects of weather systems (e.g., North Carolina, South Carolina, and Virginia); and western states in areas of high elevations and profound declines in temperatures at night (e.g., New Mexico and Arizona). From October 1993 through March 1994, a total of 23 deaths attributed to hypothermia were reported to the New Mexico Office of the Medical Investigator. This report summarizes the investigations of four of these deaths and the epidemiology for all 23 cases.
WALTER REED (1851-1902)
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NEUROSYPHILIS
Authors: WILLIAM H. TIMBERLAKE
Journal: American Journal of Psychiatry (1953)

Virulent spirochetes have been demonstrated to persist in the blood of untreated syphilitic rabbits for over 4 years and even in the face of negative serologic tests. The treponema immobilization test, a specific test for treponema pallida, has been further confirmed. It has been used to identify false positive, nonspecific serologic test results. When false positive serologic tests persist more than 6 months serious diseases, particularly the collagen diseases, should be sought as the cause. The danger of giving cortisone or ACTH to syphilitic patients who are not receiving antiluetic treatment is emphasized. Topical cortisone temporarily prevents ocular damage in interstitial keratitis. Cortisone does not prevent the Jarisch-Herxheimer reaction, which is probably of the delayed type of hypersensitivity reaction. Penicillin is the effective therapy for neurosyphilis including optic atrophy. Penicillin reactions are decreasing. When the cells and protein of the spinal fluid have been normal for 2 years, any progression of symptoms is probably due to other neurologic disease.
Aseptic meningitis among members of a high school football team. An outbreak associated with echovirus 16 infection
Authors: R. C. Baron
Journal: JAMA (1982)

During the period Sept 1 through Oct 1, 1978, an outbreak of enteroviral illness affected 43 (70%) of the 61 members of a high school football team. Thirty-three (54%) had symptoms of aseptic meningitis, a diagnosis confirmed for each of seven players hospitalized. Echovirus 16 was recovered from a throat swab of one hospitalized player and from the CSF of another. Enteroviruses isolated from stool specimens taken after the illness from other ill players and from stool specimens of non-ill team members were also identified as echovirus 16. A survey among students not on the team showed an attack rate for enteroviral-like illness that was half that experienced by team members during the same period. Symptoms reported by nonteam members were less severe. Only 10% had an aseptic meningitis-like syndrome, and none were hospitalized. Membership on the school football team was associated with an increased attack rate of illness and a greater risk for aseptic meningitis developing. (<i>JAMA</i>1982;248:1724-1727)
Eating Disorders
Authors: David B. Herzog, Paul M. Copeland
Journal: New England Journal of Medicine (1985)

Anorexia nervosa is a syndrome characterized by extreme weight loss, body-image disturbance, and an intense fear of becoming obese. Bulimia is a syndrome distinct from anorexia nervosa and is characterized by secretive binge-eating episodes followed by self-induced vomiting, fasting, or the use of laxatives or diuretics. Bulimic symptoms can also be part of the anorexia nervosa syndrome. An intense preoccupation with food is common to both syndromes, with mild or marked weight fluctuations in bulimia and severe weight loss in anorexia. Anorexia nervosa and bulimia affect as many as 5 to 10 per cent of adolescent girls and young women, . . .
Infantile amaurotic familial idocy. Leukocyte granulation and leukocyte alkaline phosphatase
Authors: F. Rosner
Journal: JAMA (1968)

Leukocyte granulation and alkaline phosphatase activity in leukocytes were studied in a group of patients with infantile amaurotic familial idiocy (Tay-Sachs disease) and a comparable group of control children. Statistically significant differences could not be demonstrated. The only patient in this series with late infantile amaurotic familial idiocy (Bielschowsky-Jansky disease) showed increased granulation of the neutrophils in his peripheral blood as well as an elevated alkaline phosphatase value in the leukocytes.
A Manual of Gynecology.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal