tbuckley/cabot-search huggingface dataset:
Die biogenen Amine und ihre Bedeutung für die Physiologie und Pathologie des pflanzlichen und tierischen Stoffwechsels
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the American Medico-Psychological Association.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quality, evolution, and clinical implications of randomized, controlled trials on the treatment of lung cancer. A lost opportunity for meta-analysis
Authors: A. Nicolucci
Journal: JAMA (1989)

A review of 150 published randomized trials on the treatment of lung cancer showed serious methodological drawbacks. Handling of withdrawals (only 7 trials had no dropouts), a priori estimates of sample size (only 9 trials specified the required number of patients), blinding of randomization (only 22 trials had a satisfactory procedure), and information on eligible nonrandomized patients (only 13 studies reported it precisely) were areas of major concern. Although trial quality improved over time both in<i>design/execution</i>(study size estimation and analysis by prognostic factors became more frequent) and<i>reporting</i>(information on patients' characteristics and side effects were more thoroughly reported), their evolution was inconsistent. For non—small-cell lung cancer—despite the persistent lack of proof of efficacy of any active treatment—an untreated control arm was prematurely abandoned and a wide variety of tested regimens prevailed even in better-quality studies. Slightly more promising is the picture for small-cell lung cancer, where research indicates somewhat more reliable—though limited—progress. While clinical research in lung cancer has contributed little to defining the best standard care, we conclude that its heterogeneity makes it unlikely that quantitative meta-analysis of existing trials will be constructive. (<i>JAMA</i>. 1989;262:2101-2107)
Carbohydrate Intolerance and Hyperlipemia in Patients with Myocardial Infarction Without Known Diabetes Mellitus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Taking the Occupational History
Journal: Annals of Internal Medicine (1983)

The occupational history is an integral part of a thorough medical interview, but may be difficult to interpret. A convenient format for obtaining an individual occupational history data base is provided, with guides to the interpretation of pertinent responses. Once completed, the occupational history can be extended by selected follow-up questions and by consulting authoritative information sources available to the clinician. The occupational history can be used on four levels: basic (a knowledge of the patient's current occupation and implications of the present illness for employment), diagnostic (to investigate an association with the present illness), screening (for individual surveillance), and comprehensive (to investigate complex problems in depth, usually in consultation with other occupational health professionals). The format provided is suitable for the screening level and to initiate investigation at the diagnostic and comprehensive levels.
Editorial: Infective endocarditis.
Journal: BMJ (1973)

Infective EndocarditisThough accurate figures on the incidence of infective endo- carditis do not exist, the available information suggests that the prevalence of ithe disease has not diminished since antibiotics became generally available.Dr. Graham Hay- ward' concluded that the number of cases today is about the same as in 1939, ithough the mortality has fallen from 100% to about 30%.If only bacteriologically positive cases are considered, mortality over the past 20 years in Hayward's own series of cases fell from 27% to 14%.
Incorrect Affiliation
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Psychiatry (2018)

Varenicline and Smoking Abstinence Among Alcohol Users 129Cigarette smoking, the leading cause of disability and death, is more than twice as common among individuals with alcohol use disorder.In a randomized clinical trial, O'Malley and colleagues found sex-specific effects in 131 alcohol-dependent smokers.Whereas men benefitted from varenicline relative to placebo on measures of heavy drinking, women showed greater adherence to placebo, and both groups showed greater smoking abstinence.In an Editorial, Evins and Kelly emphasize the safety aspect of the study and discuss the importance of increased abstinence in the absence of willingness to quit smoking.Editorial 121 Continuing Medical Education jamanetwork.com/learning Intranasal Esketamine in Treatment-Resistant Depression 139Ketamine has attracted attention as a rapid-acting antidepressant, but it is not known whether intranasal esketamine is safe and efficacious.Daly and colleagues conducted a randomized clinical trial of 3 doses of intranasal esketamine and showed that all doses had significantly greater antidepressant effect compared with placebo and that there was a significant dose-response relationship.In an Editorial, Quintana and colleagues review the implications of this study for treatment-resistant depression and for the field of intranasal drug delivery in psychiatry.
Decision Analysis
Authors: William T. Parker
Journal: JAMA (1977)

<h3>To the Editor.—</h3> I read with great interest the recent article by Dr Sisson et al (236:1259, 1976) on decision analysis. A direct extension of their evaluation scheme can be used to choose optimally the normal limits for diagnostic tests in which there is overlap between the normal and abnormal values. By knowing how the false-negatives vary with respect to the false-positives for different "normal" limits of a test, one can readily use their method to compute the total number of deaths that would ultimately occur for a variety of "normal" limits. In essence, the ultimate number of deaths can be expressed as a function of the normal limit. That particular limit which minimizes total ultimate mortality would be the optimum normal range. Since the functions involved would be higher order expressions chosen to fit test data, solution would have to be done by readily available numerical techniques on computer. As
Metabolic Effects of Carvedilol vs Metoprolol in Patients With Type 2 Diabetes Mellitus and Hypertension: A Randomized Controlled Trial—Correction
Authors: Michael Rothberg
Journal: JAMA (2004)

was validated.Second, there may be barriers to implementing a targeted program.Nevertheless, these results suggest that, while every effort should be made to divert remaining vaccine supplies toward the target groups identified by the CDC, wherever there are insufficient doses for all targetgroup members, those at highest risk should receive priority.This group includes anyone with a previous hospitalization for pneumonia or influenza, all persons older than 80 years, and patients aged 65 to 80 years with a history of cancer, pulmonary disease, heart disease, dialysis, dementia, or stroke.Encouraging healthy patients younger than 75 years to wait until those at highest risk have had a chance to be vaccinated can help maximize the population outcome this influenza season.
The Schick Test, Diphtheria and Scarlet Fever. A Study in Epidemiology.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Foreword
Journal: JNCI Journal of the National Cancer Institute (1940)

Journal Article Foreword Get access Thomas Parran Thomas Parran Surgeon General Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 1, Issue 1, 1940-1941, Page I, https://doi.org/10.1093/jnci/1.1.I Published: 01 August 1940
Errata
Journal: Circulation (1959)

Various authors have requested that the following changes be made in their published papers: BENTIVOGLIO, L. G., URICCHIO, J. F., WALDOW, A., LIKOFF, W., AND GOLDBERG, H.: An electrocardiographic analysis of sixty-five cases of mitral regurgitation. Circulation 18: 572, 1958. On page 575, table 5, Lead V 6 , Group Range, 56.0 under LVH should be 36.0; table 5, Lead V 1 , No. pts.,—(INC) under RVH &amp; IRBBB should be 1. On page 576, table 6, Lead V 5 -V 6 , No. pts., 48 (N) and 17 (PRO) under Total should be 49 (N) and 16 (PRO). On page 577, table 8, R/S Ratio in Lead V 1 , No. pts., 37 (N) under Total should be 27. On page 578, table 9, R Wave in V 1 + S Wave in V 5 ,-V 6 , No. pts., 18 (N) under Total should be 19.
Small-Bowel Endoscopy
Authors: G Gay, M Delvaux
Journal: Endoscopy (2006)

Highlights of endoscopy of the small bowel (enteroscopy) in 2004 - 2005 included the constantly growing use of capsule endoscopy (CE) in everyday practice for patients with obscure gastrointestinal bleeding [1] [2] [3], patients with Crohn’s disease [4], and in clinical trials [5], on the one hand; and the development of push-and-pull enteroscopy (PPE) on the other [6]. The papers selected for this review reflect these trends.
ASN News
Journal: Journal of the American Society of Nephrology (2006)

ASN welcomes Ronald J. Falk, MD, our newest ASN Councilor. Dr. Falk is the D.J. Thurston Professor of Medicine and Chief of the Division of Nephrology and Hypertension at the University of North Carolina (UNC) School of Medicine, as well as Director of the UNC Kidney Center. Dr. Falk has been
Erratum for Euro Surveill. 2017;22(31)
Authors:  Eurosurveillance Editorial Team
Journal: Eurosurveillance (2017)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Closure This is a corrected article applying to the following content: Evolving beta-lactamase epidemiology in Enterobacteriaceae from Italian nationwide surveillance, October 2013: KPC-carbapenemase spreading among outpatients
EV-201 study: A single-arm, open-label, multicenter study of enfortumab vedotin for treatment of patients with locally advanced or metastatic urothelial cancer who previously received immune checkpoint inhibitor therapy.
Authors: Jonathan E. Rosenberg, Elisabeth I. Heath, Peter H. O'Donnell, Noah M. Hahn, Arjun Vasant Balar, Elaina M. Gartner, Amal Melhem-Bertrandt, Daniel Peter Petrylak
Journal: Journal of Clinical Oncology (2018)

TPS542 Background: The majority of patients with locally advanced or metastatic urothelial cancer (la/mUC) will not respond to immune checkpoint inhibitors (CPIs) given in the post-platinum or cisplatin ineligible setting, and there are currently no approved standard therapies after disease progression. Enfortumab vedotin (EV), an antibody-drug conjugate, delivers the microtubule-disrupting agent monomethyl auristatin E to tumors expressing Nectin-4, which is overexpressed in mUC. Preliminary results from an ongoing phase 1 study of EV monotherapy in pts with mUC (Petrylak ASCO 2017) showed that EV was well tolerated in pts with mUC. Nausea (36%), pruritus (31%), and fatigue (30%) were the most commonly reported treatment-related AEs. The most common grade ≥3 AEs (regardless of attribution) were urinary tract infection (11%) and hypophosphatemia (9%). EV showed an objective response rate (ORR) of 41% (29 out of 71 pts) across all dose levels and 53% (16 out of 30 pts) ORR at the recommended phase 2 dose of 1.25 mg/kg. The ORR was not diminished in pts with prior CPI use (44%), prior taxane use (41%) or in pts with liver metastases (47%). These encouraging results along with a favorable safety and tolerability profile warrant further investigation of EV as a monotherapy. Methods: This single-arm, open label, multicenter phase 2 study (NCT03219333) evaluates the antitumor activity and safety of EV monotherapy in ~120 pts with la/mUC. Pts must have previously received a CPI and either have received prior platinum or be ineligible for cisplatin. Pts must have histologically or cytologically documented transitional cell carcinoma of the urothelium that progressed during or following receipt of most recent therapy. The primary objective is to determine antitumor activity of EV as measured by ORR. Secondary objectives include assessment of duration of response, disease control rate, PFS, OS, and safety/tolerability of EV. Pts must have tumor tissue available for exploratory analyses. Response is assessed per RECIST v1.1. Study enrollment began in Sept 2017. Clinical trial information: NCT03219333.
Abstract 13144: Comparison of Risk Scores for the Prediction of Stroke in African Americans: Findings From the Jackson Heart Study
Authors: Randi E Foraker, Melissa A Greiner, Mario Sims, Katherine L Tucker, Aurelian Bidulescu, Abigail B Shoben, Sakima Smith, Sameera Talegawkar, Chad Blackshear, Wei Wang, Chantelle Hardy, Amytis Towfighi, Emily O'Brien
Journal: Circulation (2015)

Introduction: Evidence from existing cohort studies supports the prediction of incident coronary heart disease and stroke using 10-year cardiovascular disease (CVD) risk scores and the American Heart Association/American Stroke Association’s cardiovascular health (CVH) metric. Hypothesis: The predictive ability would be similar between the two scoring systems for incident stroke among African-American participants of the Jackson Heart Study. Methods: We included all participants with complete scoring information at baseline who had no history of stroke (n=4,140). We used Kaplan-Meier methods to calculate the cumulative incidence of stroke, and estimated hazard ratios and 95% confidence intervals (CI) for stroke according to CVD risk and CVH score. We compared the discrimination of the two models according to the Harrell c-index and predicted versus observed stroke risk calibration plots. Results: The average age of the participants was 54.5 years, and 65% were female. The cumulative incidence of stroke increased across worsening categories of CVD risk and CVH (Figure). A one-unit increase in CVD risk increased the hazard of stroke (1.07, 1.06-1.08), while each one-unit increase in CVH corresponded to a decreased hazard of stroke (0.76, 0.69-0.83). As evidenced by the c-statistics, the CVH model was less discriminating than the CVD risk model 0.59 (0.55-0.64) versus 0.79 (0.76-0.83). However, both models had poor calibration in the uppermost and lowermost deciles of risk. Conclusions: While the CVD risk model was more discriminating than the CVH model, both scores were associated with incident stroke in a dose-response fashion. The CVH score has the advantage of simplicity in application to broad patient populations. However, by including estimates of physical activity and diet, the CVH provides a basis from which to make recommendations on behavior change. Figure. Kaplan-Meier curves for incident stroke by categories of CVD risk (left) and CVH (right).
Thermal Removal of Pyrene Contamination from Soil: Basic Studies and Environmental Health Implications
Authors: Hiroshi H. Saito, Veronica Bucala, Jack B. Howard, William A. Peters
Journal: Environmental Health Perspectives (1998)

Effects of temperature (400-10000C) and rate of heating to 550°C (100, 1000, 50000C/sec) on reduction of pyrene contamination in a Superfund-related soil and on yields of volatile products (tars, CO, CO2, methane, acetylene, ethylene) have been measured.Fifty (±3)-milligram thin layers (<150 pm) of 63-to 125-pm soil particles, neat (i.e., without exogenous chemicals), or pretreated with 4.75 wt% of pyrene, were heated for about 1 to 6 sec, under 3 psig (pounds per in.2 gauge) of helium in a 12-liter sealed chamber.Pyrene removal, defined as the difference in weight loss of neat versus contaminated soil, was virtually immune to heating rate but increased strongly with increasing temperature, approaching 100% at about 530°C.However, for pyrene- polluted soil, excess soil weight loss and modified CO yields were observed above about 500°C for a 1000°C/sec heating rate.These observations suggest that soil chemical reactions with pyrene or pyrene decomposition products augment soil volatilization.Consequently at elevated temperatures, the difference in weight loss protocol may overestimate polycyclic aromatic hydrocarbon (PAH) removal from soil.Increasing heating rate caused yields of CO, CO2, and acetylene from pyrene-polluted soil to pass through maxima.Heating neat or contaminated soil resulted in at least two gaseous products of particular environmental interest: acetylene, a precursor to PAH in thermal synthesis, and CO, a toxin to human hemoglobin.