tbuckley/cabot-search huggingface dataset:
Correction: Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis
Authors: Lourdes Ortiz-Fernández, Francisco Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul Lyons, Ann Morgan, Amr Sawalha, Peter Merkel, Kenneth Smith, Miguel González-Gay, Javier Martín
Journal: Annals of the Rheumatic Diseases (2018)
BREAST CANCER
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the NIH: NIH establishes patient registry to evaluate continuous ambulatory peritoneal dialysis
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BERLIN
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Operative Gynaecology
Authors: J. C. McClure Browne
Journal: BMJ (1969)

<h3></h3> PAPA (Pyogenic Arthritis, Pyoderma ganngrenosum, and Acne) syndrome is a rare autosomal-dominant auto-inflammatory disorder that affects joints and the skin and manifests as pyogenic arthritis, pyoderma gangrenosum and acne. We describe the first report of cerebral arterial vasculitis with rupture of an associated dissecting aneurysm in PAPA syndrome. A patient with PAPA syndrome developed thunderclap headaches, and non-invasive imaging demonstrated diffuse cerebral arterial irregularity that was consistent with a cerebral arterial vasculitis or vasculopathy. The patient was treated with steroids, but there was no improvement in the patient’s symptoms or cerebral arterial irregularity. The patient then developed subarachnoid hemorrhage secondary to rupture of a dissecting aneurysm of the right posterior cerebral artery. This aneurysm was treated by endovascular coil sacrifice of the dissecting aneurysm, and the patient made an excellent recovery. <h3>Disclosures</h3> K. Khatibi: None. J. Heit: None. N. Telischak: None. J. Elbers: None. H. Do: None.
Liquid nitrogen cryotherapy of common warts: cryo-spray vs. cotton wool bud: reply from authors
Authors: I. Ahmed, A. Ilchyshyn, J. Berth-jones
Journal: British Journal of Dermatology (2002)

Sir, We wish to reply to the comments from Drs Hutchinson and Bleiker. We were aware of the data published in abstract form by Bleiker et al.1 We have found these data difficult to interpret as they are published only in an abstract that does not provide any description of a power calculation nor confidence levels for the difference in response rates between the treatment limbs. Until now, not even the number of evaluable patients has been published. The power calculation we performed indicated that 200 evaluable subjects would be required for such a study.2 Hutchinson and Bleiker state that there were 93 evaluable subjects, although they have still not defined this population. In isolation, their data would therefore appear to yield only limited support to their conclusion that the two treatments were equally effective. It is interesting that in the study by Bleiker et al. the cure rate was slightly higher in the cryo‐spray group, whereas in our own study it was marginally higher in the cotton wool bud group (neither difference being significant).␣Taken together, these data would certainly tend to support the conclusions drawn in both reports that there is no real difference between the response rates to these two methods of applying cryotherapy.
Common Principles of Motor Control in Vertebrates and Invertebrates
Authors: P. K. G.
Journal: Annual Review of Neuroscience (1993)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Medicare
Authors: Russell B. Roth
Journal: JAMA (1966)

The Medicare Act, PL 89-97, becomes operative on July 1, 1966, in most of its phases, although the posthospital nursing home portion will not start for an additional six months. The American Medical Association, through its Advisory Committee, many individual physicians, and AMA staff representatives, has kept in close touch with developments in the drafting of the regulations for implementation of the law, and has offered extensive testimony as to things that should or should not be done in the regulatory field. On balance, it is our feeling that the Social Security Administration, the Public Health Service, and the Secretary of Health, Education and Welfare with his staff have been receptive to our advice and have followed many, but clearly not all, of our recommendations. There are, in the law and its regulations, many problem areas for physicians, as individuals and in the aggregate as a profession. It is not
Amphetamine Prescribing
Authors: D. J. Morton
Journal: BMJ (1967)

Laboratory (S.E.R.L.) at Baldock is to be congratulated on its development work on neutron generator tubes.It is no easy task to increase the output of D-T (deuteriumtritium) tubes, and the Baldock tubes with their present output of 10" neutrons per second and a tube life of the order of 100 hours or so are considerably better than simi- lar tubes developed in other countries.
Prosthetic valve endocarditis caused by Staphylococcus epidermidis. Development of rifampin resistance during vancomycin and rifampin therapy
Authors: B. Chamovitz
Journal: JAMA (1985)

Development of rifampin-resistant<i>Staphylococcus epidermidis</i>was documented in three patients receiving vancomycin and rifampin therapy for prosthetic valve endocarditis. The minimum inhibitory concentrations and minimum bactericidal concentrations of rifampin for the original three isolates were 0.4 μg/mL or less. Organisms cultured during relapse or prosthetic valve replacement had minimum inhibitory concentrations of rifampin that were 12.5, 50, and greater than 100 μg/mL, respectively. Surgical intervention was necessary in all patients. One died, and one required a second prosthetic valve placement. The patients were treated with vancomycin plus aminoglycoside following identification of rifampin resistance. These observations suggest that vancomycin and rifampin may not be adequate therapy for prosthetic valve endocarditis caused by<i>S epidermidis</i>. (<i>JAMA</i>1985;253:2867-2868)
Recent trends in suicide and homicide among blacks
Authors: E. E. Griffith
Journal: JAMA (1989)

The black community contends daily with the phenomena of suicide and homicide. However, it is the killing of black males that constitutes the heaviest burden for the group. Black suicide rates, on the other hand, continue to be lower than white suicide rates. Nevertheless, it is the black male group between the ages of 25 and 34 years that bears the brunt of both suicide and homicide. This article reviews the major theories advanced to explain the existence of these serious public health problems in the black community, suggests ways of attacking these problems, and also delineates significant areas for future research. (<i>JAMA</i>. 1989;262:2265-2269)
Practical Dermatology
Authors: P. N. Horvath
Journal: JAMA (1967)

The third edition of this text on dermatology has a number of innovations which make it an attractive source of information both for the medical student and the practitioner. This text fills the need of those who want more information than is available in the so-called manuals of dermatology and yet do not want to get involved in the time-consuming effort necessary for obtaining data from the more voluminous texts. Of particular interest is the chapter dealing with the basic sciences in relation to dermatology. This will be useful and stimulating to the medical student, although I doubt that it will attract many of the older nondermatologic readers. In addition, there is a large and quite upto-date formulary which lists not only the generic products but also many of the proprietary agents which are effective. At the end of each chapter there is an up-to-date list of references dealing with
Helping hemiparetics to help themselves. Sensory feedback therapy
Authors: J. Brudny
Journal: JAMA (1979)

Despite the presence of some voluntary movement, the loss of discrete control impairs functioning of the arm and hand in most hemiparetics. Seventy hemiparetic patients, aged 12 to 78 years, were treated and followed up for six months to three years. Electromyographic activity monitored from dysfunctional primary movers during attempted movement was displayed to the patients as a continuous oscilloscopic trace, reflecting generated muscle activity and allowing its quantification. Coupled with operant conditioning techniques, these displays were modified gradually by reinforcing the patient's effort with auditory feedback during successive approximations to a desired level. Such therapeutic use of electromyographic displays often resulted in a progressive improvement of voluntary movement. More than half the patients acquired and retained purposive movements that meaningfully improved their functional capabilities. (<i>JAMA</i>241:814-818, 1979)
Int Arch Allergy &amp;amp; Appl Immunology, Basel
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HYSTERICAL MOVEMENTS.
Authors: HOWELL T. PERSHING
Journal: JAMA (1905)

I understand that in assigning me the subject of hysterical movements it was not intended to include the phenomena of the ordinary hysterical convulsion, but rather to bring up for discussion such motions of hysterical origin as may best be considered in comparison with chorea and convulsive tic. Thus restricted the subject is a very important but very difficult one. I would not undertake to say anything about it had it not been assigned to me. Certain general principles are applicable to all such movements, and to avoid needless repetition they may first be briefly stated. The possibility of organic disease must always be considered and the signs that would reveal it carefully looked for in the examination; only when it has been excluded are we safe in attempting to discriminate among the functional diseases. Hysteria being a functional disease of the cortex, the motions caused by it are always
Hookworm Infection.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXTH-08. NOVEL OLIG2 INHIBITOR DEMONSTRATES PRE-CLINICAL EFFICACY IN PEDIATRIC GBM
Authors: Holly Lindsay, Yuchen Du, Mary Sobieski, Clifford Stephan, Lin Qi, Huiyuan Zhang, Frank Braun, Sibo Zhao, Mari Kogiso, Murali Chintagumpala, D. Will Parsons, Gordon Alton, Gregory Stein, Graham Beaton, Xiao-Nan Li
Journal: Neuro-Oncology (2016)

Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) is pro-mitotic, expressed almost exclusively in the central nervous system (CNS), and is highly expressed in gliomas. We evaluated the in vitro and in vivo efficacy of CT-179, an OLIG2 chemical inhibitor, alone and combined with radiation in pediatric glioblastoma (pGBM) in addition to its tolerability and penetration into the CNS. Cells from 8 patient tumor-derived orthotopic xenograft pGBM models with elevated OLIG2 expression were treated with CT-179 (0-10 µM) in both serum-based and serum-free media (favoring enrichment of tumor stem cells). Cell viability was measured 5 times over 2 weeks. Tumor cells were then exposed to varying doses of CT-179 (0-1 µM) and radiation (0-8 Gy). Inhibition of cell growth and colony-forming efficiency were determined with high-throughput imaging. Finally, 105cells of two types of pGBM were orthotopically-implanted into mice. After 2 weeks, 4 weeks of treatment was initiated with vehicle, focal radiation (2 Gy/day, 5 days), CT-179 (15 mg/kg, gavage), or radiation plus CT-179. Drug concentration was examined in blood, normal brain, and tumor. CT-179 inhibited cell viability in both time- and dose-dependent manners in all 8 pGBM tumors in both media (IC50 0.03-10 µM). Radiation potentiated the effects of CT-179 at low to moderate drug doses (0.03-1 µM). In vivo treatment in two pGBM xenograft models has been completed, and survival analysis is ongoing. When enterally dosed, CT-179 preferentialy accumulates in the cerebrum. The OLIG2 inhibitor CT-179 demonstrated in vitro efficacy against numerous pGBM samples. CT-179 is well tolerated in vivo and accumulates in the cerebrum. Our data suggest that OLIG2 inhibition may be an effective strategy for future pGBM clinical trials.
Role of partial nephrectomy in solitary or bilateral renal tumors
Authors: J. M. Palmer
Journal: JAMA (1983)

Partial nephrectomy was carried out successfully in seven of eight cases of solitary or bilateral renal carcinoma. Although three patients with bilateral sequential lesions died of subsequent metastatic disease, their deaths occurred after 33 to 52 months of productive life without the need for end-stage treatment of renal disease. One patient died free of disease of myocardial infarction at 45 months, and the remaining three were alive without evidence of tumor 62, 76, and 85 months after the procedure. No patient suffered local recurrence of tumor, and the need for dialysis in three patients was only temporary. Partial nephrectomy is a viable option in the management of solitary or bilateral renal carcinoma. (<i>JAMA</i>1983;249:2357-2361)
Cytotoxic and Mutagenic Effects of Specific Carcinogen-DNA Adducts in Diploid Human Fibroblasts
Authors: J. Justin McCormick, Veronica M. Maher
Journal: Environmental Health Perspectives (1985)

A comparison of the cytotoxicity and mutagenicity of a series of carcinogens in normal diploid human fibroblasts and in cells deficient in one or more DNA repair processes has provided insight into the specific DNA adduct(s) responsible for these biological effects. The carcinogens tested include ultraviolet radiation; reactive derivatives of structurally related aromatic amides; metabolites of benzo(a)pyrene; the simple alkylating agents N-methyl-N'-nitro-N-nitrosoguanidine and N-ethyl-N-nitrosourea; and aflatoxin B1 dichloride, a model for the reactive 2,3-epoxide of aflatoxin B1. Exponentially growing cells were exposed to agents and assayed for mutations (induction of 6-thioguanine resistance) and cell killing (loss of colony-forming ability). Cells deficient in repair of particular DNA adducts or lesions proved more sensitive to the agent causing those lesions than did normally repairing cells. Many of the carcinogens were compared for their mutagenic and/or cytotoxic effect, not only as a function of dose administered, but also as a function of the initial number of adducts or photoproducts induced in DNA and the number remaining at critical times posttreatment. Density-inhibited cultures were exposed to cytotoxic and mutagenic doses. Immediately after treatment, or after various lengths of time in confluence, the cells were harvested and analyzed for the number of lesions remaining in DNA. A portion was plated at lower densities and assayed for mutations and/or for survival. In several instances, the adducts were analyzed by high-pressure liquid chromatography. As an alternative approach, cells were synchronized and treated at various times prior to the onset of DNA synthesis and analyzed for survival and/or the frequency of mutations. The results demonstrated a high correlation between the number of DNA lesions remaining unexcised at the time the DNA was replicated and the frequency of mutations induced. Comparative studies of the frequency of UV-induced transformation (to anchorage independence) of normal and repair-deficient cells showed this also to be true for transformation.
The prophylactic use of cephalosporins for surgery
Authors: B. L. Moskovitz
Journal: JAMA (1985)

<h3>In Reply.—</h3> The comments by Dr Moskovitz are appreciated and deserve further explanation. We recognize that new antimicrobials with relatively long half-lives (eg, cefonicid, ceforanide, and ceftriaxone) have been shown to be effective when used prophylactically in single preoperative doses; however, the literature supports the older and less expensive, "first-generation" cephalosporins (eg, cefazolin) as being effective for prophylaxis when administered in single preoperative doses. Traditionally, older cephalosporins have been studied for surgical prophylaxis using regimens where two to 20 postoperative doses were provided in addition to a preoperative dose.<sup>1</sup>Where these agents have been studied using only single preoperative doses, they have been found effective.<sup>1</sup>Multidose regimens are not, therefore, generally "necessary." For example, Lewis et al<sup>2</sup>reported recently that a single preoperative dose of cefazolin is effective in decreasing postoperative infection rate in high-risk biliary surgery. Our own investigations have demonstrated that cefazolin produces adequate intraoperative
Praktische Arbeitsphysiologie.
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal