tbuckley/cabot-search huggingface dataset:
"Getting Married"
Authors: R. Long
Journal: BMJ (1959)

In the present study we tested the hypothesis that prenatal nicotine exposure increases heart susceptibility to ischemia/reperfusion (I/R) injury in adult offspring. Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps throughout gestation. Nicotine treatment resulted in a rapid and transient decrease in food-intake and a moderate decrease in maternal body weight gain. Hearts were isolated from adult male and female offspring and subjected to I/R in a Langendorff preparation. Nicotine significantly attenuated left ventricle (LV) developed pressure, heart rate, and coronary flow rate in female but not male hearts at baseline. Additionally, nicotine significantly increased LV infarct size and attenuated postischemic recovery of LV function in both male and female offspring with more pronounced effects in females. In female but not male hearts, nicotine significantly decreased the postischemic coronary flow rate. However, coronary nitric oxide release was decreased in male but not female hearts. Caspase-3, -8, and -9 levels were not significantly changed in either female or male hearts. However, nicotine caused a significant decrease in protein levels of protein kinase (PK) Cϵ in both male and female hearts and a decrease in PKCδ levels in female hearts only. Control studies of maternal food restriction showed that a moderate decrease in maternal body weight gain had no effect on female hearts but significantly improved postischemic recovery of LV function in male hearts. The results suggest that prenatal nicotine exposure causes in utero programming of the PKC isozyme gene expression pattern in the developing heart and increases heart susceptibility to I/R injury in adult offspring.
Peculiar Reactions Between the Fifth and Seventh Cranial Nerves.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrections
Authors: N Bennett, Newcastle Upon, A Buchan, A Davis, N Rowell, P Uldall, S Mossawy, M Colin-Thome, T Kinnis, R Spector, M Warren, D.-J Brown, K Lewin, R Newman, G Besser, A Gorchein, V Maggi, P Richards, J Osborn, P Tantivatana, Welsh Wales, -J Aggarwal, R Batten, D Hiley, Ruth Hughes, Isabel Morgan, D Walters, Ruth Barry, K Browne, P Conway, R Garnett, S Gassama, Wendy George, F Glynn, D Hill, Vyvyan Jackson, Sui-Lin Joy, I Lian, A Mackenzie, A Nlie, G Pointer, M Purnell, Sandra Ranson, W Bevington, M Leeds, A Appleyard, A Cargill, Vivienne Eid
Journal: BMJ (1967)
Diagnostic Endocrinology
Authors: Charles B. Clayman
Journal: JAMA (1979)

The tremendous advance in our ability to measure infinitesimally small amounts of circulating hormone or hormonal metabolic by-products is used by the author to correlate these findings with the physiology and pathophysiology of all the endocrine systems. He initiates the book with a careful, clear discussion of receptors competitive binding, and radioimmunoassay. The remainder of the book relates these findings to the function and malfunction of each of the endocrine glands. Other sources will be required for the reader interested in symptoms, signs, and other clinical features of the various entities. However, this small handy text provides all the current data regarding the many circulating substances that may now be measured in evaluating endocrine glandular function.
MIGRATING EPIDERMAL CELLS
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies in Cancer and Allied Subjects.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrections to Address Revised Analysis in Related Study
Journal: JAMA (2020)

In the Original Contribution entitled "Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore" 1 published online in JAMA on March 3, 2020, there were errors in the text, a figure, and the end matter.In the second paragraph of the "Case Management" section in the text, the dose for coformulated lopinavir-ritonavir reported as 200 mg/100 mg should have been reported as 400 mg/100 mg.At the top right of Figure 1, "February 202" should have read "February 2020.
A Definition of Irreversible Coma
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reproductive characteristics of Mexican-American, mainland Puerto Rican, and Cuban-American women Data from the Hispanic Health and Nutrition Examination Survey
Authors: C. A. Stroup-Benham
Journal: JAMA (1991)

Data from the Hispanic Health and Nutrition Examination Survey were used to investigate reproductive characteristics of Hispanic females aged 15 to 45 years. Mexican-American and Puerto Rican women reported approximately 1.9 and 1.7 live births each, respectively, whereas Cuban-American women reported 1.1. Mexican-American women were more likely to be using oral contraceptives and were more likely to have had a hysterectomy or an oophorectomy than were Cubans and Puerto Ricans. The largest percentage of tubal ligations were found among Puerto Rican women. Mexican women who had been pregnant in the previous 12 months were more likely than their Puerto Rican and Cuban-American counterparts to be breastfeeding. Further research is needed to investigate the decision processes and/or cultural variations that may be responsible for these differences in reproductive traits across national origin groups. (<i>JAMA</i>. 1991;265:222-226)
Liver toxicity in the Phase 2 Catalyst 206 trial of Inarigivir 400 mg daily added to a nucleoside in HBV EAg negative patients
Authors: Kosh Agarwal, Nezam Afdhal, Carla Coffin, Scott Fung, Geoffrey Dusheiko, Graham Foster, Magdy Elkhashab, Edward Tam, Alnoor Ramji, Radhakrishnan Iyer, Patrick Kennedy
Journal: Journal of Hepatology (2020)
Misplaced Headings in Educational Number
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elusive allowances.
Authors: L Mackenzie, C Aitken
Journal: BMJ (1981)

The disabled are confused about the development, prescription, and use of all health and welfare services available to them.'Among these services are cash benefits, and, whether they like it or not, the medical profession plays a large part in helping patients obtain them-for instance, by assessing eligibility.As part of a study on the level of knowledge and use of the health and welfare services by disabled people we inquired into the cash benefits that a sample of them received. Methods and resultsThe sample was taken from registers held at a vehicles for the disabled centre in Edinburgh and an artificial limb and appliance centre in Glasgow.A total of 714 was selected at random from those living in South Scotland, of whom 255 became available for interview at home.Two-thirds of these were wheelchair users, most having had their chair for over a year.Most were elderly; over half had degenera- tive neurological or joint disorders, and one in 10 had had a leg amputated.Some 63% of the sample received at least one form of cash benefit -excluding supplementary benefit, retirement pension, and war disablement pension (table I).Most had first learnt about the various allowances from the mass media-primarily the radio, followed by newspapers and television-and from chance meetings with informed
Efficacy and Safety of Extended-Release Venlafaxine in the Treatment of Generalized Anxiety Disorder in Children and Adolescents: Two Placebo-Controlled Trials
Authors: Moira Rynn
Journal: American Journal of Psychiatry (2007)

Objective: The authors evaluated the efficacy, safety, and tolerability of extended-release venlafaxine in the treatment of pediatric generalized anxiety disorder. Method: Two randomized, double-blind, placebo-controlled trials were conducted at 59 sites in 2000 and 2001. Participants 6 to 17 years of age who met DSM-IV criteria for generalized anxiety disorder received a flexible dosage of extended-release venlafaxine (N=157) or placebo (N=163) for 8 weeks. The primary outcome measure was the composite score for nine delineated items from the generalized anxiety disorder section of a modified version of the Schedule for Affective Disorders and Schizophrenia for School-Age Children, and the primary efficacy variable was the baseline-to-endpoint change in this composite score. Secondary outcome measures were overall score on the nine delineated items, Pediatric Anxiety Rating Scale, Hamilton Anxiety Rating Scale, Screen for Child Anxiety Related Emotional Disorders, and the severity of illness and improvement scores from the Clinical Global Impression scale (CGI). Results: The extended-release venlafaxine group showed statistically significant improvements in the primary and secondary outcome measures in study 1 and significant improvements in some secondary outcome measures but not the primary outcome measure in study 2. In a pooled analysis, the extended-release venlafaxine group showed a significantly greater mean decrease in the primary outcome measure compared with the placebo group (–17.4 versus –12.7). The response rate as indicated by a CGI improvement score <3 was significantly greater with extended-release venlafaxine than placebo (69% versus 48%). Common adverse events were asthenia, anorexia, pain, and somnolence. Statistically significant changes in height, weight, blood pressure, pulse, and cholesterol levels were observed in the extended-release venlafaxine group. Conclusions: Extended-release venlafaxine may be an effective, well-tolerated short-term treatment for pediatric generalized anxiety disorder.
THE BACHELOR'S DEGREE AND THE MEDICAL COLLEGE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improved methods for thyroid scanning. A correlation with surgical findings
Authors: M. N. Maisey
Journal: JAMA (1973)

To determine how often thyroid scanning correctly predicts the diagnosis of thyroid abnormalities, 59 patients who had thyroid surgery were examined with the scintillation camera shortly before operation. To improve the intrinsic resolution of the system, the thyroid gland was magnified two to three times normal size by using a pinhole collimator. With the higher-quality images, multinodular thyroids were correctly detected in 65% of the patients. Twenty-five were interpreted as solitary nodules; two were thought to be normal glands; one was diagnosed as diffuse hyperplasia. In only 39 (22%) of the patients with multinodular goiter were the nodules palpable. The remainder were diagnosed clinically as solitary nodules. Of 26 solitary nodules, 20 were seen in the images. When solitary nodules were not visible in the images, they were either small (&lt;0.5 cm in diameter) or in the isthmus.
Characterization of in vivo Somatic Mutations at the Hypoxanthine Phosphoribosyltransferase Gene of a Human Control Population
Authors: Karolyn Burkhart-Schultz, Cynthia B. Thomas, Claudia L. Thompson, Cheryl L. Strout, Eleanor Brinson, Irene M. Jones
Journal: Environmental Health Perspectives (1993)

The ability to recognize a change in mutation spectrum after an exposure to a toxic substance and then relate that exposure to health risk depends on the knowledge of mutations that occur in the absence of exposure. Toward this end, we have been studying both the frequency and molecular nature of mutations of the hypoxanthine phosphoribosyltransferase (hprt) gene in peripheral blood lymphocytes as surrogate reporters of genetic damage. We have analyzed mutants, one per donor to ensure independence, from a control population in which the quantitative effects of smoking and age on mutant frequency have been well defined. Analyses of cDNA and genomic DNA by polymerase chain reaction and sequencing have identified the mutations in 63 mutants, 45 from males and 18 from females, of which 34 were smokers and 29 were nonsmokers. Slightly less than half of the mutations were base substitutions; they were predominantly at GC base pairs. Different mutations at the same site indicated that there are features of the hprt polypeptide that affect the mutation spectrum. Two pairs of identical mutations indicated that there may also be hot spots. Mutations not previously reported have been detected, indicating that the mutation spectrum is only partly defined. The remainder of the mutations were deletions or insertions/duplications; deletions ranged from one base pair to complete loss of the locus. Despite a small average increase in mutant frequency for smokers, an increased proportion of base substitutions at AT base pairs in smokers (p = 0.2) hinted at a smoking-associated shift in the mutation spectrum.(ABSTRACT TRUNCATED AT 250 WORDS)
Intravenous cholangiography.
Authors: Elliott C. Lasser
Journal: JAMA (1963)

In this monograph, the author inclusively summarizes his extensive experience with intravenous cholangiography over the past five years at the Lahey Clinic and the New England Baptist Hospital. The major contribution of this text resides in the emphasis on the time-density-retention concept elaborated in an earlier report by the author. With this scheme, one can evaluate the presence or absence of relative obstruction of the common bile duct, when either the gallbladder has been removed or the cystic duct occluded. This is accomplished by comparing the density of contrast material in the common duct at 60 and 120 min postinjection. If the density continues to increase beyond 60 min, the inference is partial common duct obstruction. Considerable roentgenographic evidence is advanced to refute the concept that the common duct dilates in the postcholecystectomy patient in the absence of obstructive disease of this structure. The text reflects favorably the author's exhaustive
Pneumococcal Meningitis And Endophthalmitis in a Newborn
Authors: Ralph N. Otto
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Keyes et al recently reported an association between meningococcemia and endocervical infection in two patients and remarked on the uniqueness of this association.<sup>1</sup>We encountered a case in which a relatively asymptomatic pneumococcal infection of the endocervical area of a mother led to fatal pneumococcal meningitis in a live born infant who remained asymptomatic until 5 days of age. <h3>Report of a Case.—</h3> A 5-day-old female infant was born at term via low forceps delivery to a 23-year-old primigravida who had had an uneventful pregnancy except for mild preeclampsia. The child, with an initial apgar core of 3, required suction and oxygen, but within five minutes the respirations were normal. She received silver nitrate prophylaxis to the eyes, and on day 4 the child was discharged as a healthy newborn. The mother was disturbed by the foul odor of the vaginal discharge, but was afebrile and
Thromboembolism in Patients Receiving Progestational Drugs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detection of hereditary hemochromatosis and biochemical iron overload in primary care: A multicenter case finding study in Spain
Authors: Núria Freixenet, Maria Sierra Moreno‐Rosel, Maria Jesús Barceló, Antonia Serrano, Marina Payà, Lourdes Crespo, Maria José Pérez‐Lucena, Albert Altés, Montserrat Baiget, Jordi Félez
Journal: American Journal of Hematology (2014)

By Núria Freixenet,1 Maria Sierra Moreno-Rosel,1 Maria Jesús Barceló,2 Antonia Serrano,1 Marina Payà,3 Lourdes Crespo,3 Maria José Pérez-Lucena,4 Albert Altés,5 Montserrat Baiget,2 and Jordi Félez1 Am. J. Hematol. 2010 Apr; 85(4):294–6. Doi: 10.1002/ajh.21634 In the above-referenced article, the author did not include the name of the Universitat Autónoma de Barcelona (UAB), to which the authors were affiliated. We apologize for any confusion this error might have caused.
Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Determinants of Osteonecrosis In Children with Acute Lymphoblastic Leukemia.
Authors: Jitesh D. Kawedia, Sue Kaste, Deqing Pei, John C Panetta, Xiangjun Cai, Cheng Cheng, Geoffrey A. Neale, Scott C Howard, William E. Evans, Ching-Hon Pui, Mary V. Relling
Journal: Blood (2010)