tbuckley/cabot-search huggingface dataset:
Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer
Authors: A. Fyles, M. Milosevic, D. Hedley, M. Pintilie, W. Levin, L. Manchul, R. P. Hill
Journal: Journal of Clinical Oncology (2002)

PURPOSE: This prospective clinical study was begun in 1994 to validate the independent prognostic impact of tumor hypoxia in patients with cervix cancer treated with definitive radiation therapy. PATIENTS AND METHODS: Between May 1994 and January 1999, 106 eligible patients with epithelial cervix cancer had tumor oxygen pressure (PO 2 ) measured using the Eppendorf probe. Oxygenation data are presented as the hypoxic proportion, defined as the percentage of PO 2 readings less than 5 mm/Hg (abbreviated as HP 5 ) and the median PO 2 . RESULTS: The median HP 5 in individual patients was 48%, and the median PO 2 was HP 5 . Progression-free survival (PFS) for patients with hypoxic tumors (HP 5 &gt; 50%) was 37% at 3 years versus 67% in those patients with better oxygenated tumors (P = .004). In multivariate analysis, only tumor size (risk ratio [RR], 1.33; P = .0003) and evidence of pelvic nodal metastases on imaging studies (RR, 2.52; P = .0065) were predictive of PFS. However, an interaction between nodal status and oxygenation was observed (P = .006), and further analysis indicated that HP 5 was an independent predictor of outcome in patients with negative nodes on imaging (P = .007). There was a significant increase in the 3-year cumulative incidence of distant metastases in the hypoxic group (41% v 15% in those with HP 5 &lt; 50%; P = .0023), but not in pelvic relapse (37% v 27%; P = .12). CONCLUSION: Tumor hypoxia is an independent predictor of poor PFS only in patients with node-negative cervix cancer, in addition to tumor size. Its impact appears to be related to an increased risk of distant metastases rather than to an effect on pelvic control.
Outdoor Air Pollution and Your Health
Authors: Mary Rice, John Balmes, Atul Malhotra
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Air pollution is the name for the mixture of harmful particles and gases in the air around us that we breathe.Air pollution is produced by both human activity and naturally occurring events.Burning of fossil fuels by motor vehicles (including cars, buses and trucks) and power plants (including coal-fired and natural gas plants) releases a mixture of pollutants, such as tiny particles (particulate matter, PM), nitrogen oxides (NOx) and volatile organic compounds (VOCs).Chemical reactions in the atmosphere between NOx and VOCs produce ground-level ozone, a component of smog.Naturally-occurring sources of pollutants include forest fires, volcanoes, and dust storms.Forest fires release a range of pollutants, from particulate matter and acrolein (a respiratory irritant) to carcinogens (causing cancer) such as formaldehyde and benzene.Dust particles from roads or desert environments also pollute the air.Tiny airborne particles from power plant emissions or forest burning can travel thousands of miles and affect the air quality in distant places.In general, pollution levels are highest closest to the source of emission.
NEW SPECIFIC BLOOD REACTION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thrombolysis for acute myocardial infarction in patients older than 75 years: Lack of benefit for hospital mortality but improvement of longterm mortality: Results of the MITRA- and MIR-registries Anselm K. Gitt, Ralf Zahn, Harm Wienbergen, Tobias Heer, Steffen Schneider, Martin Gottwik, Martin Gottwik, Jochen Senges, Rudolf Schiele. Herzzentrum Ludwigshafen, Ludwigshafen, Germany
Journal: Journal of the American College of Cardiology (2001)
Notes and Illustrations of the Disquisition on Puerperal Fever
Authors: E. Blackmore
Journal: BMJ (1845)

Ainsi le meilleur medicin n'est Pas celui qui en aveugle et an courant ac¢umule beaucoup de pratique; maim celui qui ne fait que des observations biens appro.fondies, et qui joint a cesi observations le nombre le beaucoup plus grand des observations faites par des bommes animds dui meme esprit que lui; ces observa- tions-sont le veritable experience du medecin."-D'AlIembert.l WAat sort of case is to be regarded as puerperal fever If it is a specific disease, it should have some defini- tive character.Is there any particular symptom that is pathoeonic, or is the disease to be known froum the combination and' definite proportion of the symp- toms; or from its successive states and terminations?It is obvious, on the most cursory view of the cases reported by various writers under this designation, that very different morbid affections have been con.founded under this term; and hence the most contra- dictory statements bave been set forth on the nature and treatment of puerperal fever.The late illustrious professor of midwifery at Edinburgh, Dr. James Hamilton, wlhose lectures were unrivalled for the comprehensive description of diseases, and the rich stores of practical matter which they con.tained, although they were deficient in exact patholo.gical reasoning, maintained that, a case marked by a " sudden attack of pyrexia, exquisite pain, distension, and heat of the abdomen, a pulse at 140, disordered breatbing, sickness, diarrhcea, thirst, and delirium;' is not (necesarily) an example of puerperal fever.He asserted that such a case has been erroneously called so by certain popular writers on the subject; that it is
Sudden death brings East and West together
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors’ Reply
Authors: Igor Denizarde Bacelar Marques, Rosilene Motta Elias, Rosa Maria Affonso Moysés, Elias David-Neto
Journal: Journal of the American Society of Nephrology (2019)

We thank Tabibzadeh et al. for their comments. We agree that bisphosphonates are safe and the fear of adynamic bone disease should not be a reason to preclude its use in kidney transplant recipients. We believe that this is one of the main findings of our study.1 Our data confirmed that we should not have safety concerns with these drugs. Moreover, besides not having safety issues, bisphosphonates should be used in kidney transplant patients, as suggested by our data. Findings of bone mineral gain on central skeleton assessed by dual-energy X-ray absorptiometry that have been shown by Segaud et al.,2 our group, and others, must be confronted with the bone loss at peripheral sites. Therefore, we agree that pretransplant bone evaluation should include either high-resolution peripheral quantitative computed tomography or forearm dual-energy X-ray absorptiometry. As stated in the article and emphasized by Tabibzadeh et al., the design of our study precluded the inclusion of deceased-donor kidney transplant. However, in Brazil and worldwide, this is the most common type of kidney transplant.3 Usually, these patients are older, with longer dialysis duration, a more severe form of CKD-mineral and bone disorder, and lower baseline bone mineral density than the patients included in our study. Indeed, a recent study in our center found that almost half of the patients on dialysis had low bone mineral density.4 Therefore, the benefits of zoledronic acid would be more prominent in these patients. We believe that the next step would be performing prospective and placebo-controlled studies, evaluating the effects of prophylactic use of bisphosphonates on fracture prevention. This would help us to identify the subset of patients that would benefit from this therapy and perhaps include bisphosphonates in the standard care of some kidney transplant recipients. Disclosures None.
PLASMA EXPANDERS
Authors: I. S. Ravdin
Journal: JAMA (1952)

There is no substitute for blood. Medical officers in World War II who had sufficient amounts of blood and plasma available used four times as much blood as plasma in patients with a deficiency of blood volume. At present, there is no substance available that can assume the many functions that a good preparation of whole blood is now known to have. Interest in substances that act as poor substitutes for blood or as satisfactory substitutes for plasma occurs periodically during times of impending national emergency. The problem of whole blood and plasma logistics for our military forces as well as for our civilian population will be an extremely difficult one in the event major atomic disasters occur as a part of war. Our hope for preventing and combating shock in the great multitude of casualties that will inevitably follow such a disaster lies in plasma expanders, which are capable
Medical education in the United States. V. Educational programs in areas allied to medicine
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Group Sizes in Figure
Journal: JAMA (2021)

Amy G. Cantor, MD, MPH; Rebecca M. Jungbauer, DrPH, MPH, MA; Marian McDonagh, PharmD; Ian Blazina, MPH; Nicole E. Marshall, MD, MCR; Chandler Weeks, MPH; Rongwei Fu, PhD; Erin S. LeBlanc, MD, MPH; Roger Chou, MD
Epidemiology in sickle cell disease. Lessons learned from the CADRE cohort in Africa
Authors: Brigitte Ranque
Journal: HemaSphere (2018)

Paris Descartes University, Paris, France This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
SPECIAL NOTICES.
Authors: A. S. V. Mansfelde
Journal: JAMA (1884)

Ashland, Neb., April 14, 1884. <h3>Editor Journal American Medical Association, Chicago.</h3><h3>Dear Doctor:</h3> —The Nebraska State Medical Society will meet in annual session at 9 o'clock A. M., Tuesday, May 13, in the city of Omaha. Physicians in affiliation with the A. M. A., who may intend going West, are cordially invited to attend our meeting. Very truly yours,
HMOs Report Quality Improvements
Authors: B. Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Faculty practice plans. Profile and critique
Authors: G. K. MacLeod
Journal: JAMA (1986)

In 1910, the Flexner report signaled the end of commercialism in American medical schools, only to have it reappear in 1931. Between 1960 and 1985, access to federal, state, and private-sector funds paid to medical service plans in all 127 medical schools led to almost a 20-fold increase in faculty practice plan (FPPs)—from six to 118. All 127 US medical schools were surveyed. Wide swings in federal funding policies left medical schools with a defective management model, particularly for FPPs. Disposition of collected revenues, the role of for-profit FPPs, the personally lucrative nature of FPPs, an unwieldy number of fairly autonomous departments, ineffective governance, and hostile opposition from other parts of the university have raised questions of conflict of interest and accountability. Some 75 years after the Flexner report, a thorough evaluation of the effects of commercialism on medical education once again appears to be warranted. (<i>JAMA</i>1986;256:58-62)
Intravenous labetalol in acute aortic dissection
Authors: B. P. Grubb
Journal: JAMA (1987)

ACUTE dissection of the aorta is one of the most common clinical catastrophes involving the aorta. At least 2000 new cases occur each year in the United States alone,<sup>1,2</sup>and reports have suggested that the incidence of this disorder may be increasing in the industrialized world, with as many as ten to 20 new cases per million population per year.<sup>3</sup> During the last 20 years, major advances have occurred in our ability to diagnose and treat this devastating disorder. Coupled with the strides made in surgical therapy,<sup>4</sup>prompt medical therapy has dramatically improved survival. Medical therapy consists of lowering both the blood pressure (BP) and the velocity of left ventricular ejection (dV/dt).<sup>5</sup>Agents used include trimethaphan camsylate and the combination of sodium nitroprusside and propranolol hydrochloride. However, these agents are often cumbersome to use and difficult to administer safely during both interhospital and intrahospital transport. Labetalol
Bloodwork
Authors: Julie Dunlop
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The future of clinical research in Britain
Journal: BMJ (1986)

I wonder if I might add some points to Dr Linda Beeley's answer on whether antibiotic drugs reduce the effectiveness of oral contraceptives (22 February, p 528).Rifampicin is known to induce hepatic enzymes and this can cause a reduction in the effectiveness of anticoagulants, corticosteroids, digitalis preparations, oral contraceptives, and oral hypoglycaemic agents.'Pregnancies have apparently resulted from this interaction.2 3In the data sheet for rifampicin it is recommended that women taking oral contraceptives should use an alternative, non-hormonal method of contraception during rifampicin treatment.4Although UK product licences do not allow the recommenda- tion of rifampicin for treatment ofany condition other than tuberculosis, it is known to be used in (among others) short course prophylaxis for contact with meningococcal meningitis.Enzyme induction has been shown to occur in a matter of days,5 and the warning should also be given to patients treated with short course prophylaxis.1 Acocella G, Conti R. Interaction of rifampicin with other drugs.
Arrived
Authors: Richard Donze
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nonrandom Distribution of Breakpoints in the Karyotypes of Workers Occupationally Exposed to Benzene
Authors: Maria Sasiadek
Journal: Environmental Health Perspectives (1992)

The distribution of the breakpoints in the karyotypes of workers occupationally exposed to benzene was tested. Fifty-six workers exposed to benzene were investigated cytogenetically. A significant increase in chromosome aberrations was observed. The distribution of the breakpoints in the karyotypes of examined workers was significantly nonrandom (p less than or equal to 0.001). The breakpoints accumulated mainly on chromosomes 2, 4, and 7.
In Vitro Studies on the Biologic Effects of Fibers: Correlation with In Vivo Bioassays
Authors: Brooke T. Mossman
Journal: Environmental Health Perspectives (1990)

In vitro studies employing organ cultures, primary cell cultures, cell lines, and bacterial systems have been used to assess the toxicity, mutagenicity, and carcinogenic potential of asbestos and nonasbestos fibers. These experiments have been useful in defining mechanisms contributing to the causation of fiber-associated lung diseases. Long (greater than 8 microns), thin asbestos fibers are more active in vitro than short (less than or equal to 2 microns) fibers or nonfibrous particles, an observation supporting the importance of fiber dimension in disease. Although in vitro bioassays cannot evaluate characteristics such as clearance and/or durability of fibers which may be critical determinants of fiber toxicity in lung, they can be used both to address dosimetry at the cellular level (i.e., number of fibers per cell that elicit a measurable biologic end point) and to evaluate preventive approaches to fiber-induced cell injury. Development of in vitro models employing target cells of the lung, i.e., mesothelial cells, tracheobronchial epithelial cells, and lung fibroblasts, as well as carefully characterized preparations of fibers and particles, will be necessary to evaluate whether in vitro bioassays are amenable to predicting the pathogenic potential of synthetic and naturally occurring fibers comparatively.
Editorial Correspondence.
Authors: John B. Hamilton
Journal: JAMA (1894)

San Francisco, Cal., June 4, 1894. We left Denver at 2:30A.M., May 31, and arrived at Colorado Springs at 5A.M.It still rained, and the Pike's Peak railway having been washed out by the mountain floods, there was nothing to do but to see what we could of Colorado Springs. Mr. Buckman, of the Chamber of Commerce, informed us that the El Paso Club was open to the pilgrims and many availed themselves of the privilege. Dr. Anderson invited a party to luncheon in the afternoon, and Dr. Solly invited a party to dinner. It rained too hard to go out and there was music and dancing at the "Antlers." There was no prospect of getting away by the Colorado Midland and the railway company finally concluded to send us to California by way of the Atchison, Topeka &amp; Santa Fé, Mojave route, and we remained that night