tbuckley/cabot-search huggingface dataset:
Adverse reactions to penicillin
Authors: G. Westerman
Journal: JAMA (1966)

Sensitivity reactions to penicillin continue to be a major medical problem occurring in as high as 5% to 10% of those receiving it.<sup>1</sup>Allergic reactions to penicillin account for approximately 10% of the reported adverse drug reactions in the United States and are now the most common type of anaphylactic shock. Although attempts are being made to limit its indications, one must recall that penicillin is the only available potent bactericidal drug which is relatively innocuous and therefore shall continue to enjoy broad usage. Restriction of usage is complicated further by ever increasing sources of unintentional penicillin administration or ingestion which serve as avenues for sensitization (milk, viral vaccines, foods, etc). Although parenteral administration causes most sensitization, ingestion may occasionally be incriminated.<sup>2</sup>The prevention and treatment of these allergic reactions are important to all medical and dental practitioners and ultimately to their patients. This review is designed to
Megaesophagus, Megacolon, and Chagas' Disease in Chile
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leprosy. A disease of the heart
Authors: R. Crawshaw
Journal: JAMA (1982)

WHILE IN India last summer, I was invited by Dr Shubhada Pandya to join her at the Acworth Leprosy Hospital, Bombay, and then to accompany Dr R. Ganapati, a public health officer, on his rounds in Bombay's Dharavi slum. The taxicab ride to Acworth Leprosy Hospital passes through some prosperous sections of Bombay, yet the ride, as in every city of the Far East, is a battering encounter with masses of people. In addition, the ride had the eerie quality of a submarine dream, for the drenching monsoon with its oppressive humidity had me soaked in my own sweat as I peered through the steamy, rain-streaked windows. The sidewalks were crowded with makeshift cardboard and plastic hovels that seemed like barnacles growing along the base of the buildings. The underwater effect was reinforced by the swirl of bicycles passing like schools of fish and clusters of umbrellas hopping up and
This Week in &lt;emph&gt;JAMA&lt;/emph&gt;
Journal: JAMA (2010)

A Piece of My Mind"If he had been blessed with the privileges that I have, or if I had been born to his social circumstances, would our seats in the courtroom have been reversed?"From "Letter to a Father in Jail." SEE PAGE 1347 Medical News & PerspectivesThe US Food and Drug Administration is calling for more limited use of longacting ␤-agonists to reduce rare but serious adverse events associated with the drugs.
Results of implementing a novel supportive oncology screening tool for comprehensive evaluation of distress and other supportive care needs.
Authors: Julia Rachel Trosman, James Gerhart, Urjeet Patel, Paramjeet Khosla, Patricia A. Robinson, Frank J. Penedo, Aidnag Diaz, Teresa Lillis, Harry Miranda, Erika K. Radeke, Betty Roggenkamp, Mary Pasquinelli, Lawrence Eric Feldman, Joanna Martin, Shelly S. Lo, Sheetal Mehta Kircher, Sofia F. Garcia, Rosa Berardi, Christine B. Weldon
Journal: Journal of Clinical Oncology (2017)

e21644 Background: The Institute of Medicine (IOM) 2013 Report recommends that supportive oncology care start at cancer diagnosis; the Commission on Cancer (CoC) Standard 3.2 requires distress screening and indicated action. Screening tools are not standardized and often address only a portion of patients’ supportive oncology needs. Methods: A collaborative of 100+ clinicians, funded by The Coleman Foundation, developed a patient-centric screening tool adapted from NCCN Distress Problem List, IOM report and CoC standards, with validated sub-tools: PHQ-4 for anxiety and depression and PROMIS short forms for pain, fatigue and physical function. Novel treatment/care and other concerns were included. The screening tool was implemented at 4 cancer centers (2 academic, 1 public &amp; 1 safety-net). End points included correlation of PHQ-4 score with other supportive oncology needs. Descriptive statistics, Fisher’s exact test were used. Results: 2805 patients were screened. Average scores were: PHQ4 – Anxiety and Depression 1.8 (mild &gt; 3), Pain 4.5 (mild &gt; 4), Fatigue 8.8 (mild &gt; 6), Physical Function 20.2 (mild &lt; 20), see table for additional items. Higher scores on the PHQ-4 were significantly associated with each of the following: greater pain, fatigue, nutritional and specific treatment/care concerns, and lower physical function (p&lt;.0001). Conclusions: Patients with higher anxiety and depression also have many other supportive oncology concerns. Our results support the use of a comprehensive tool capturing a spectrum of each patient’s unique concerns. This may enable earlier interventions and personalized delivery of supportive care. [Table: see text]
Elevated baseline CRP levels predict death or MI in diabetic patients undergoing percutaneous coronary intervention Deepak L. Bhatt, Derek P. Chew, Mark A. Robbins, Marco Roffi, Leslie Cho, Jay S. Yadav, A. Michael Lincoff, Eric J. Topol, Stephen G. Ellis. Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)
BI-21 * BRAF MUTATION AND CDKN2A DELETIONS DEFINE A CLINICALLY DISTINCT SUBGROUP OF CHILDHOOD SECONDARY HIGH GRADE GLIOMA
Authors: M. Mistry, N. Zhukova, D. Merico, P. Rakopoulos, R. Krishnatry, M. Shago, J. Stavropoulos, P. Ray, J. Mangerel, M. Remke, P. Buczkowicz, V. Ramaswamy, J. Rutka, P. Dirks, M. Taylor, E. Bouffet, D. Malkin, A. Huang, C. Hawkins, U. Tabori
Journal: Neuro-Oncology (2014)

PURPOSE: Pediatric secondary high grade glioma (sHGG), which result from malignant transformation of low grade glioma (PLGG), are a poorly understood group of tumors with devastating outcomes. PATIENTS AND METHODS: We performed a population-based study combined with long-term follow-up of PLGG that transformed to sHGG. Exonic-sequencing and copy number alterations were investigated on a discovery cohort, followed by detailed genetic analysis of all tumors. Clinical and outcome data analysis of a genetically distinct subgroup was performed. RESULTS: sHGG were observed in 28/888 (3.2%) patients treated in Southern Ontario for PLGG with a median latency of 2.74 years (range, 0.18-20.3 years). sHGG were characterized by a high somatic mutation load (23 per genome). Alterations in chromatin modifying genes and major telomere maintenance pathways were observed in 57% and 54% of sHGG respectively. However, specific mutations in IDH1, H3F3A G34 and ATRX were extremely rare. The most recurrent somatic alterations were the oncogenic BRAF V600E mutation and deletion of the tumor suppressor gene CDKN2A, observed in 39% and 57% of sHGG respectively. Importantly, all BRAF V600E and 80% of CDKN2A alterations could be traced to the patient-matched PLGG counterparts. These early alterations were rarely observed in non-transformed PLGG (p < 0.0001) and primary childhood high grade glioma (p = 0.0023). The BRAF mutant sHGG subgroup was characterized by longer latency periods to transformation than non-BRAF mutant sHGG (median 6.59 versus 1.62 years; p < 0.0001). Furthermore, 5-year overall survival of children with BRAF mutant and wild-type PLGG that transformed were 75% ± 15% and 29% ± 12% respectively (p = 0.024). CONCLUSION: BRAF V600E mutations and CDKN2A deletions constitute a clinically distinct subtype of sHGG. The prolonged course to transformation provides a window of opportunity for aggressive surgical interventions, targeted therapy against oncogenic BRAF, and extended surveillance to potentially mitigate the devastating transformation event.
On Puerperal Fever
Authors: T. S. Beck
Journal: BMJ (1865)

of "restoratives"-to regard the two things as antagonistic-is to go back a hundred years for our prmciples of pathology.In the sense inferred, therefore, it is quite a fallacy to say, that an "effort is being made to restore bleeding in pneumonia."I do not look upon venesection as of any use quoad the pneumonia; nor do have ceased to employ it for this purpose.When coagula form in the interior of the organ, it is often
Book Review Synopsis of the Preparation and Aftercare of Surgical Patients . By Hugh C. Ilgenfritz, M.D., and Rawley M. Penick, Jr., M.D. With a foreword by Urban Maes, M.D., D.Sc. 12°, cloth, 532 pp., with 55 illustrations. St. Louis: The C. V. Mosby Company, 1941. $5.00.
Journal: New England Journal of Medicine (1942)
Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: A multivariate analysis
Authors: Masayoshi Yamauchi, Yoshihiko Maezawa, Yuji Mizuhara, Mitsuru Ohata, Junichi Hirakawa, Hisato Nakajima, Gotaro Toda
Journal: Hepatology (1995)

Alcohol dehydrogenase (ADH), aldehyde dehydrognase (ALDH), and P450IIE1 are the primary enzymes that catalyze the conversion of ethanol to acetaldehyde and then to acetate. Genetic polymorphisms have been reported in ADH2, ADH3, ALDH2, and the 5′-flanking region of P450IIEI. In this study, we used multivariate analysis to determine which genetic polymorphisms in alcohol metabolizing enzymes were independently associated with the development of alcoholic cirrhosis. Thirty-four noncirrhotic alcoholic patients, including 27 with fatty liver and 7 with nonspecific changes, and 46 patients with alcoholic liver cirrhosis were studied. Restriction fragment length polymorphisms (RFLPs) in the ADH2 and P450IIE1 genes were detected by digestion of polymerase chain reaction (PCR)-amplified DNA with Mae III and Rsa I, respectively. In the ALDH2 gene, RFLPs were detected by differences in the MboII site after PCR amplification. By multivariate analysis of four significant factors including total alcohol intake, ADH, ALDH, and P450IIE1 using the multiple logistic regression model, genotype ADH2 2 /ADH2 2 (P = .029) and genotype c1/c1 of P450IIE1 (P = .013) were found to be independently associated with alcoholic cirrhosis. The odds ratios for ADH2 2 /ADH2 2 genotype and the type A genotype of P450IIE1 (c1/c1) were 4.600 and 4.006, respectively. These results suggest that ADH2 and P450IIE1 gene polymorphisms may be independently associated with the development of alcoholic liver cirrhosis in Japan. (HEPATOLOGY 1995; 22:1136-1142.).
Manuale di Materia Medica.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea Advanced Inst of Science & Tech (KAIST) JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
The Netherlands introduces some competition into the health services
Authors: A. J. Schrijvers
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Percutaneous Recanalization of Chronically Occluded Coronary Arteries
Authors: Gregg W. Stone, David E. Kandzari, Roxana Mehran, Antonio Colombo, Robert S. Schwartz, Steven Bailey, Issam Moussa, Paul S. Teirstein, George Dangas, Donald S. Baim, Matthew Selmon, Bradley H. Strauss, Hideo Tamai, Takahiko Suzuki, Kazuaki Mitsudo, Osamu Katoh, David A. Cox, Angela Hoye, Gary S. Mintz, Eberhard Grube, Louis A. Cannon, Nicolaus J. Reifart, Mark Reisman, Alexander Abizaid, Jeffrey W. Moses, Martin B. Leon, Patrick W. Serruys
Journal: Circulation (2005)

R emarkable progress in the percutaneous management of coronary artery disease has been achieved over the last decade.The scaffolding properties of coronary stents have resulted in percutaneous coronary intervention (PCI) becoming a predictable procedure, with reduced rates of acute closure and late restenosis compared with balloon angioplasty alone. 1,2More recently, the site-specific delivery of antiproliferative agents from drug-eluting stents has been demonstrated to markedly attenuate vascular responses leading to neointimal hyperplasia, further reducing the occurrence of clinical and angiographic restenosis to Ͻ10% in most patients. 3,4][7] With these advances in perspective, it is often stated that successful recanalization of chronic total occlusions (CTOs) of native coronary arteries represents the "last frontier" of PCI.This statement is made in deference to the fact that CTOs represent the most technically challenging lesion subset that interventional cardiologists face, with procedural success rates considerably lower than those achieved in nonoccluded coronary vessels or acutely occluded arteries.Moreover, no consensus exists with regard to the definition of CTO, the factors related to procedural failure and/or complications, and the optimal technical approach.Indeed, until recently, the clinical benefits of PCI in CTOs had not been demonstrated.An international panel of 47 physicians from 9 countries was therefore convened in New York City for 2 days in January 2004, the purpose of which was to reach consensus on the current state of the art of CTO angioplasty (see Appendix in the online-only Data Supplement for a complete participant list).This goal was approached through a series of didactic lectures, roundtable discussions, breakout focus groups, and the performance of 14 live case demonstrations of CTO angioplasty by many of the world's most skilled operators in this subspecialty.The present report represents a synthesis of the findings from this meeting and also incorporates a literature review from the field of CTO intervention.Topics covered in Part I of this review include definitions, prevalence, and clinical presentation of CTOs; the anatomy and histopathology of coronary occlusions; experimental CTO models; and the clinical relevance and rationale for CTO revascularization.Part II will review the technical approach to and clinical outcomes after percutaneous intervention of CTOs and describe the novel devices and drugs approved and undergoing investigation for CTO recanalization.
Tricyclic antidepressant overdose: incidence of symptoms
Authors: J. T. Biggs
Journal: JAMA (1977)

Forty consecutively hospitalized patients who had overdosed primarily with a tricyclic antidepressant (TCA) were observed until discharge. The severity of the overdose was documented by serial measurements of plasma TCA levels. Nineteen of the patients became comatose, 16 required supportive respiration, and 2 died. Individual symptoms in the 13 patients having plasma TCA levels greater than 1,000 ng/ml are shown. Plasma TCA measurements more reliably define patients who are at risk for major medical complications following overdose than does the amount of drug ingested by history. In the absence of plasma measurements, a QRS duration of 100 msec or more on a routine ECG within the first 24 hours defined all patients with major TCA overdoses. (<i>JAMA</i>238:135-138, 1977)
Chirurgie de la main: Plaies, infections et chirurgie réparatrice.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical and social welfare.
Journal: BMJ (1966)

BRITJSHthe remainder from older children or adults.A team in Glasgow, comprising workers from both the University Department of Child Health and the hospital service, analyses about 200 samples each year, almost all from children aged under 5 years.The Glasgow survey is confined to a limited geographical region, and has access to clinical records and other material which permit detailed interpretation of the results.The English survey gives a better sample of the country as a whole.Other work now in progress includes the study of strontium metabolism by the use of radioactive tracers in adult volunteers and by the analysis of diet and urine in infants.The problem of strontium metabolism, linked as it is with the growth and maintenance of the skeleton, is necessarily a long-term project.The British work now under way has produced useful results from a modest expenditure of effort, and its value may be expected to grow continually over the next decade.
The sneeze
Authors: J. Graner
Journal: JAMA (1983)

<h3>To the Editor.—</h3> I enjoyed Dr Kavka's<sup>1</sup>interesting article on the sneeze. In general, he did a masterful job of describing the mystery and continued fascination engendered by this complex act. He has, however, omitted several important references to the sneeze in his article. Hippocrates (<i>Aphorisms</i>, section 6, No. 13) found a useful function for sneezes: "Sneezing coming on, in the case of a person afflicted with hiccup, removes the hiccup."<sup>2</sup> William Harvey<sup>3</sup>found the stimulus to sneeze helpful in inducing childbirth: I knew a young woman, who, by reason of the extremity of her labour in giving birth, fell into a swoon and immediately became so prostrated... that no remedies could arouse her. Being called to her... I put a feather covered with a strong sneezing powder to her nostrils. By this she was roused... her whole body began to be seized by a kind of
The Value of Continuing Regular Papanicolaou (Pap) Smears in Postmenopausal Women
Journal: Annals of Internal Medicine (2000)

Summaries for Patients19 December 2000The Value of Continuing Regular Papanicolaou (Pap) Smears in Postmenopausal WomenSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-12-200012190-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?The recommended method of screening for cervical cancer in women before menopause is to do a Pap smear every 1 to 3 years. It is unclear whether continuing regular Pap smears in women after menopause is of value. Professional organizations' recommendations vary from continuing Pap smears throughout life to stopping them at age 65 in women whose Pap smears were previously normal. “False-positive” Pap smears are frequent in women after menopause; this means the test appears abnormal, but the woman does not have an important cervical problem. It ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “The Positive Predictive Value of Cervical Smears in Previously Screened Postmenopausal Women: The Heart and Estrogen/progestin Replacement Study (HERS).” It is in the 19 December 2000 issue of Annals of Internal Medicine (volume 133, pages 942-950). The authors are GF Sawaya, D Grady, K Kerlikowske, J La Valleur, VM Barnabei, K Bass, TE Snyder, JH Pickar, SK Agarwal, and J Mandelblatt, for the Heart and Estrogen/progestin Replacement Study (HERS) Research Group.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Positive Predictive Value of Cervical Smears in Previously Screened Postmenopausal Women: The Heart and Estrogen/progestin Replacement Study (HERS) George F. Sawaya , Deborah Grady , Karla Kerlikowske , June La Valleur , Vanessa M. Barnabei , Katherine Bass , Thomas E. Snyder , James H. Pickar , Sanjay K. Agarwal , Jeanne Mandelblatt , and Metrics 19 December 2000Volume 133, Issue 12Page: I-61KeywordsCervical cancerEstrogen replacement therapyEstrogensHeartHormonesLongitudinal studiesMenopausePositive predictive valueProgesteroneUterus ePublished: 19 December 2000 Issue Published: 19 December 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...