tbuckley/cabot-search huggingface dataset:
Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919.
Authors: Karen A. Gelmon, Frances Boyle, Bella Kaufman, David Huntsman, Alexey Manikhas, Angelo Di Leo, Miguel Martin, Lee Steven Schwartzberg, Susan Faye Dent, Susan Ellard, Katia Sonia Tonkin, Yasir M. Nagarwala, Kathleen I. Pritchard, Timothy Joseph Whelan, Dora Nomikos, Judy-Anne W. Chapman, Wendy Parulekar
Journal: Journal of Clinical Oncology (2012)

LBA671 Background: The relative efficacy of L vs T when combined with Tax chemotherapy in the first-line setting of metastatic breast cancer (BC) is unknown. Methods: MA.31 compares Tax-based therapy, paclitaxel 80mg/m 2 wkly or docetaxel 75mg/m 2 3 wkly for 24 wks in combination with L or T. The L dose was 1,250 mg po daily with Tax followed by 1,500 mg daily (LTax/L). After a loading dose, the T dose was 2 mg/kg wkly or 6 mg/kg 3 wkly + Tax followed by T 6 mg/kg 3 wkly (TTax/T). Stratification was by prior neo/adjuvant HER2 therapy, prior neo/adjuvant Tax, planned Tax (paclitaxel vs docetaxel), and liver metastases. The primary endpoint is ITT progression-free survival (PFS), defined as time from randomization to objective progressive disease based on RECIST criteria or death from any cause. The protocol-specified IA was performed after observing 333 PFS events; the trial was to stop if the 2-sided p-value from the stratified log-rank test was less than 0.03. The NCIC CTG’s independent DSMC reviewed IA results and recommended disclosure because the superiority boundary was crossed. A secondary analysis utilized central laboratory-confirmed HER2 + status. Results: Between July 17 2008 and Dec 1 2011, 652 pts were accrued. Data from 636 pts (525 HER2 centrally confirmed) were included in the IA with clinical cutoff date of Nov 7 2011 and database lock of Apr 13 2012. Median follow-up was 13.6 mos, 12.9 mos for LTax/L pts and 14.0 mos for TTax/T patients. In the ITT analysis, PFS was inferior with LTax/L compared to TTax/T hazard ratio (HR) =1.33; 95% CI 1.06-1.67; p=0.01. LTax/L had median PFS 8.8 mos (95% CI 8.3-10.6) compared to TTax/T 11.4 mos (95% CI 10.8-13.7). PFS in the centrally confirmed HER2+ had HR 1.48 (95%CI 1.15-1.92; p=0.003) (LTax/L to TTax/T). No difference in overall survival was detected (LTax/L to TTax/T) HR= 1.1 (95% CI 0.75-1.61; p=0.62). More grade 3-4 diarrhea and rash was observed with LTax/L (p&lt;0.001). Conclusions: LTax/L therapy is associated with a shorter PFS compared to TTax/T as first line therapy for HER2+ metastatic BC. ClinicalTrials.gov: NCT00667251. CCSRI grant: 021039. Supported by GlaxoSmithKline.
Hypothermic Hump
Authors: Edwin L. Rothfeld
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In their communication on "Rapid Active External Rewarming in Accidental Hypothermia," (<b>212</b>:153, 1970), Fernandez et al describe the electrocardiographic features of hypothermia. While most of these alterations are nonspecific, the authors state that "... prominent J or 'camel hump' waves are pathognomonic of hypothermia." We seriously doubt that a prominent J deflection, as an isolated finding, is diagnostic of anything, because we see it frequently in normothermic, young adults who have no demonstrable cardiac or extracardiac disease. Often, such QRS alterations are observed in association with sinus arrhythmia and physiologic ST-T changes as demonstrated in the Figure. We agree that the constellation of bradycardia, conduction defects, QT prolongation, and "camel hump" or J deformities is highly suggestive of hypothermia. On the other hand, we cannot accept the statement that the "hypothermic hump" is a pathognomonic feature.
Andante
Authors: Ian P. Wicks
Journal: Annals of Internal Medicine (2012)

Ad Libitum17 July 2012AndanteIan P. Wicks, MB BS, PhDIan P. Wicks, MB BS, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-2-201207170-00017 Audio Reading - “Andante” Audio. A reading of "Andante" by Ian P. Wicks Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail We have been walking this way for so longBipedalOne small step in front of anotherAlways in touch with the sly groundIn the longest, least self conscious dance of our livesSecure ball and socket, the angled fulcrum of the hiptakes all our weight, and moreDown the mighty femur, to the button-braced kneeperilous hinge, locking straightHeel strike shudders through the ankle mortice,splays delicate rays of the plantar archPinioned, but only brieflybefore tendo-Achilles pushes down for lift offand ... Author, Article, and Disclosure InformationAffiliations: Current Author Address: Ian P. Wicks, MB BS, PhD, Rheumatology Unit, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia; e-mail, Ian.[email protected]org.au. PreviousarticleNextarticle Advertisement Audio Reading - “Andante” Audio. A reading of "Andante" by Ian P. Wicks Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 17 July 2012Volume 157, Issue 2Page: 147KeywordsAnklesFemurHipKneesRheumatologyTouchWalking ePublished: 17 July 2012 Issue Published: 17 July 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Report of the Council on Medical Education and Hospitals
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Repeated peritoneal dialysis in treatment of heart failure
Authors: R. M. Raja
Journal: JAMA (1970)

A patient with refractory heart failure and anasarca underwent eight peritoneal dialyses during a 21-month period. Clinical response to the dialyses was excellent. To our knowledge, this is the first patient upon whom repeated peritoneal dialysis was used over a prolonged period of time for refractory heart failure.
ANTIDEGENERACY LEGISLATION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentaire de travail de Spaeth A et al., pp. 560
Journal: Endoscopy (2013)

See also: Use of lower gastrointestinal endoscopy and fecal occult blood test in the 2007 Swiss Health Interview Survey respondents aged 50 years and olderEndoscopy 2013; 45(07): 560-566DOI: 10.1055/s-0032-1326636
Hepatic abscess. Diagnosis in the adult by total body opacification
Authors: M. E. Morin
Journal: JAMA (1976)

Two adults had the hypovascular nature of their hepatic abscesses ascertained by total body opacification. In one, total body opacification identified the hypovascular nature of the lesion, facilitating its differentiation from vascular hepatoma. In the other, the clinical diagnosis was acute cholecystitis with empyema of the gallbladder, and the liver was normal to inspection and palpation at celiotomy. Total body opacification may be helpful in the examination of abdominal masses. (<i>JAMA</i>236:1607-1608, 1976)
442P Results from the registrational phase I/II ARROW trial of pralsetinib (BLU-667) in patients (pts) with advanced RET mutation-positive medullary thyroid cancer (RET+ MTC)
Authors: B. Keam, M.I. Hu, V. Subbiah, L. Wirth, M. Schuler, A.S. Mansfield, M.S. Brose, G. Curigliano, S. Leboulleux, V.W. Zhu, I. Matos, D. Adkins, C.S. Baik, G. Lopes, Y. Godbert, D. Sarker, H. Zhang, C.D. Turner, M.H. Taylor, C-C. Lin
Journal: Annals of Oncology (2020)
A bullet and a bull moose
Authors: W. J. Foley
Journal: JAMA (1969)

The assassin's bullet played an unique role in the presidential career of Theodore Roosevelt. He became president when McKinley was shot by the anarchist Czolgosz, and his efforts to regain the presidency from Taft in the campaign of 1912 ended for all practical purposes in Milwaukee with his own attempted assassination by an unemployed saloonkeeper from New York named John Schrank. Roosevelt had completed a whistle-stop tour of the South, and was just beginning his campaign swing through the Midwest. Late in the afternoon of Oct 14, his train arrived in Milwaukee, where he was to speak in the evening at the civic auditorium. He originally had planned to have dinner in his own railroad car, the<i>Mayflower</i>, but decided instead to go to the Gilpatrick Hotel to have a good bath and eat with some of the local Bull Moose. There—although he did not know it—he also would meet
Evaluation of long-term efficacy of interferon alpha-2B and ribavirin in combination in naive patients with chronic hepatitis C: An italian multicenter experience
Authors: G. Barbaro, G. Di Lorenzo, G. Belloni, L. Ferrari, A. Paiano, J. Del Poggio, D. Bacca, L. Fruttaldo, F. Mongiò, R. Francavilla, G. Scotto, B. Grisorio, G. Calleri, M. Annese, A. Barelli, P. Rocchetto, G. Rizzo, G. Gualandi, I. Poltronieri, A. Pellicelli, G. Barbarini
Journal: Journal of Hepatology (2000)
Time for Action on Drug Safety
Authors: Deborah Shatin, Jacqueline S. Gardner, Andy Stergachis
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostics
Authors: T. R. Einert, G. Schmidt, G. Binnig, O. Balacescu, L. Balacescu, M. Rus, R. Buiga, O. Tudoran, N. Todor, V. Nagy, A. Irimie, I. Neagoe, R. Yacobi, E. Ustaev, R. R. Berger, I. Barshack, K. Kaur, S. Henderson, A. Cutts, E. Domingo, J. Woods, C. Motley, B. Dougherty, M. Middleton, B. Hassan, Y. Wang, E. Beasley, M. Naley, A. Schuh, I. Tomlinson, J. Taylor, D. Planchard, B. Lueza, A. Rahal, L. Lacroix, M. Ngocamus, N. Auger, P. Saulnier, P. Dorfmuller, T. Le Chevalier, A. Celebic, J. P. Pignon, J. C. Soria, B. Besse, Y. H. Sun, R. Wang, C. G. Li, Y. J. Pan, H. Q. Chen, L. Chouchane, J. Shan, D. Kizhakayil, I. Aigha, S. Dsouza, B. Noureddine, S. Gabbouj, R. Mathew, E. Hassen, L. Chouchane, S. Shan, K. al-Rumaihi, I. al-Bozom, S. al-Said, D. Rabah, K. Farhat, D. Kizhakayil, I. Aigha, I. A. Jakobsen Falk, K. H. Z. Green, K. Lotfi, A. Fyrberg, T. Pejovic, H. Li, P. Mhawech-Fauceglia, M. Hoatlin, M. G. Guo, M. Huang, Y. Ge, K. Hess, C. Wei, W. Zhang, T. A. Bogush, E. A. Dudko, M. V. Nureev, A. A. Kamensky, B. E. Polotsky, S. A. Tjulandin, M. I. Davydov, M. Caballero, J. Hasmats, H. Green, M. Quanz, C. Buhler, J. S. Sun, M. Dutreix, C. L. Cebotaru, R. Buiga, A. N. Placintar, N. Ghilezan, Z. B. Balogh, L. Reiniger, H. Rajnai, J. Csomor, A. Szepesi, A. Balogh, L. Deak, E. Gagyi, C. Bodor, A. Matolcsy, V. K. Bozhenko, N. I. Rozhkova, E. A. Kudinova, O. P. Bliznyukov, E. N. Vaskevich, I. D. Trotsenko, V. K. Bozhenko, N. I. Rozhkova, N. V. Kharchenko, E. A. Kudinova, O. P. Bliznyukov, I. V. Kiandarian, I. D. Trotsenko, C. Pulito, I. Terrenato, A. Sacconi, F. Biagioni, M. Mottolese, G. Blandino, P. Muti, E. Falvo, S. Strano, F. Mori, A. Sacconi, F. Ganci, R. Covello, C. Zoccali, R. Biagini, G. Blandino, S. Strano, G. A. Palmer, W. Wegdam, D. Meijer, G. Kramer, J. Langridge, P. D. Moerland, S. M. de Jong, J. P. Vissers, G. G. Kenter, M. R. Buist, J. M. F. G. Aerts, M. Milione, F. de Braud, R. Buzzoni, S. Pusceddu, V. Mazzaferro, A. Damato, G. Pelosi, M. Garassino, F. de Braud, M. Broggini, M. Marabese, S. Veronese, M. Ganzinelli, O. Martelli, F. Ganci, N. Bossel, A. Sacconi, G. Fontemaggi, V. Manciocco, I. Sperduti, E. Falvo, L. Strigari, R. Covello, P. Muti, S. Strano, G. Spriano, E. Domany, G. Blandino, S. Donzelli, A. Sacconi, T. Bellissimo, G. Alessandrini, S. Strano, M. A. Carosi, E. Pescarmona, F. Facciolo, S. Telera, A. Pompili, G. Blandino, V. de Vriendt, W. de Roock, A. F. di Narzo, S. Tian, B. Biesmans, B. Jacobs, J. de Schutter, E. Budzinska, X. Sagaert, M. Delorenzi, I. Simon, S. Tejpar, Y. Zhu, H. K. Wang, D. W. Ye, E. Denisov, M. Tsyganov, L. Tashireva, M. Zavyalova, V. Perelmuter, N. Cherdyntseva, Y. C. Kim, T. Jang, I. J. Oh, K. S. Kim, H. Ban, K. J. Na, S. J. Ahn, H. Kang, W. J. Kim, C. Park, N. K. Abousamra, M. S. El-Din, E. A. Azmy
Journal: Annals of Oncology (2012)
Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase: Erratum
Authors: Jiang-Kai Dong, Hui-Min Lei, Qian Liang, Ya-Bin Tang, Ye Zhou, Yang Wang, Shengzhe Zhang, Wen-Bin Li, Yunguang Tong, Guanglei Zhuang, Liang Zhang, Hong-Zhuan Chen, Liang Zhu, Ying Shen
Journal: Theranostics (2021)
A Randomized Controlled Trial of Patient Controlled Analgesia Versus Continuous Infusion of Morphine during Vaso-Occlusive Crisis in Sickle Cell Disease.
Authors: Eduard J. Beers van, Charlotte F.J. Tuijn van, Pythia T. Nieuwkerk, Philip W. Friederich, Marcel M. Levi, Jan H. Franken, Bart J. Biemond
Journal: Blood (2006)
Arsenic in water.
Journal: BMJ (1969)

JOLMNALshort course of treatment were less likely to relapse, while those found infected on follow-up tended to relapse after a second course of treatment.Similar results were reported from a study of non-pregnant women.14Dr. Savage and his colleagues make the important point that in the management, just as in the diagnosis, of these symptomless patients with bacteriuria there is need for care- fully controlling any type of treatment which is to be given if large numbers of children are not to receive long courses of unnecessary drugs for an indefinite period.
Reliability and Validity of a Diabetes Quality-of-Life Measure for the Diabetes Control and Complications Trial (DCCT)
Journal: Diabetes Care (1988)

We have developed a diabetes quality-of-life (DQOL) measure oriented toward the patient with insulin-dependent diabetes mellitus (IDDM). The DQOL was assessed for its reliability and validity in a group of patients with IDDM (n = 192). We found that the DQOL and its four scales had high degrees of internal consistency (Cronbach's r = .66−.92) and excellent test-retest reliability (r = .78−.92). Using conceptually relevant measures of psychiatric symptoms, perceived well-being and adjustment to illness, we also demonstrated convergent validity of the DQOL. This instrument was initially designed for use in the Diabetes Control and Complications Trial, a multicenter controlled clinical trial evaluating the effects of two different diabetes treatment regimens on the appearance and progression of early vascular complications. However, the DQOL may also be useful in evaluating the quality of life in other groups of patients with IDDM.
Questions and Answers on Cancer
Journal: CA A Cancer Journal for Clinicians (1973)

Questions andAnswers on CancerWhat is the management of a 36-year old white female, gravida 3. para 2. at 26 weeks of gestation with an infiltrating carcinoma of the breast, without fixa tion and without palpable nodes.Specif ically, what is the: (a) management of breast disease?(b) management of this pregnancy?(c) future managementâ€"radiation? prophylactic oophorectomy?pal liative oophorectomy?chemo therapy?future pregnancies?
Federal Officials Hearing Plenty (of Opposition) During Comment Period on New Laboratory Rules
Authors: Marsha F. Goldsmith
Journal: JAMA (1990)

FINAL RULES issued by the federal government, aimed at further regulating cytology laboratories and cytology professionals, appear to be close to the last straw for leaders of their specialty organizations. At this year's joint spring meeting in San Francisco, Calif, the American Society of Clinical Pathologists' (ASCP) president, George D. Lundberg, MD, and the College of American Pathologists' (CAP) president, Loyd R. Wagner, MD, spoke out against the recently promulgated proficiency requirements for those engaged in detecting abnormalities in Papanicolaou smears. "A strong backlash is beginning to develop," Lundberg says, "among leaders in the professional laboratory community against the dictatorial tactics of the Department of Health and Human Services and the Health Care Financing Administration [HCFA], particularly in relation to its recent issuing of these final rules. While HCFA spokespersons admit that there is no scientific basis for claiming that the type or frequency of proficiency testing that they have
Die Morphin-Erkrankungen.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlighting Cancer Chemotherapy Reports
Authors: J. B. Block
Journal: CA A Cancer Journal for Clinicians (1970)

The August issue of Cancer Chemotherapy Reports contains several articles which illustrate the methods, failures and occasional success of new drug development for clinical trials in the United States.The article by Morrison et al. on toxicologic studies with mitomalcin in dogs is reported from the John L. Smith Memorial for Cancer Research in Maywood, New Jersey, and from the National Cancer Institute in
Computational Errors and Incorrect Analysis in Study on Primary School Closures
Journal: JAMA Network Open (2021)

there were computational errors and an incorrect analysis used.Corrections to address these errors include the presentation of 2 estimates for potential years of life lost associated with school closure, using separate weighted relative risk estimates from US-based and European-based studies for the association between lost education and mortality.These corrections affect the Abstract; Methods, Results, and Discussion sections; Figure 2; and the Supplement.
1989
Authors: Michael Collins
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal