tbuckley/cabot-search huggingface dataset:
Whither the Foreskin?
Authors: E. Noel Preston
Journal: JAMA (1970)

Routine neonatal circumcision has been advocated as a means of preventing genitourinary diseases and genital cancers. However, the procedure has been found to be of questionable benefit and to be associated with both immediate and delayed risks and complications. These in turn may produce undesirable psychologic, sexual, and medico-legal difficulties. Circumcision is considered with respect to carcinoma of the cervix, penis, and prostate; there is little evidence that circumcision of the newborn affords protection against subsequent development of these cancers in individuals who practice good personal hygiene.
Stethoscope Sounds
Authors: Rae Varcoe
Journal: Annals of Internal Medicine (2007)

Ad Libitum21 August 2007Stethoscope SoundsRae Varcoe, MA, MB, ChBRae Varcoe, MA, MB, ChBFrom Auckland Hospital, Auckland 1, New Zealand.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-4-200708210-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail the flutter/pause coarseningof the in breath's crepitusor a sibilant song of rhonchiwhistling on the out breathmaybe the insistent iambof a foetal heartor an embarrassment of borborygmisneaking gaseously southheart sounds beating their retreata regular debit on a finite ledgerand sometimessilenceRae Varcoe, MA, MBChBAuckland HospitalAuckland 1, New Zealand Author, Article, and Disclosure InformationAffiliations: From Auckland Hospital, Auckland 1, New Zealand.Current Author Address: Rae Varcoe, MA, MB, ChB, Haematology Department, Auckland Hospital, Park Road, Auckland 1, New Zealand; e-mail, [email protected]co.nz. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 August 2007Volume 147, Issue 4Page: 277KeywordsHeartHematology and oncology ePublished: 21 August 2007 Issue Published: 21 August 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The importance of adverse reaction reporting by physicians. Suprofen and the flank pain syndrome
Authors: A. C. Rossi
Journal: JAMA (1988)

The role of spontaneous reporting in detecting the suprofen-associated flank pain syndrome was examined, including the specific effect of the "Dear Doctor" letter in accelerating the information-gathering process once the initial signal was generated. We believe this to be a noteworthy example of the ability of spontaneous reporting to produce a timely and unequivocal signal of drugrelated risk. It also serves to demonstrate the need for vigilant postmarketing surveillance for all newly marketed drugs in the United States, even though considerable premarketing and postmarketing drug experience may exist from use in countries outside of the United States. (<i>JAMA</i>1988;259:1203-1024)
THE DUST CONVEYANCE OF TYPHOID FEVER.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Discussion of Reports on Neural Factors in Hypertension
Journal: Circulation (1958)

Dr. Tobian commented on the possibility of increased fluid content of arterioles as a cause of the altered vascular reactivity described by Dr. Conway. Dr. Lewis described the arterial vasodilation in the digit following ganglion blockade. Dr. Stamler reviewed the conference proceedings and attempted to interrelate the many reports presented. He concluded with a restatement of the central role of the kidney in the pathogenesis of human hypertension and emphasized the importance of determining whether neurogenic, inflammatory, or arteriosclerotic influences were the factors which initiated the renal lesion.
Pharmacology, Materia Medica and Therapeutics
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase Ib trial of xentuzumab and abemaciclib in patients with locally advanced or metastatic solid tumors, hormone receptor-positive (HR+), HER2-negative (HER2-) breast cancer (BC; +/- endocrine therapy), or non-small-cell lung cancer (NSCLC)
Authors: D. Yee, A. Prat, M.P. Sablin, H. Iwata, E.L. Johnston, T. Bogenrieder, J. Serra, H. Hua, P. LoRusso
Journal: Annals of Oncology (2017)
Dextroamphetamine for epilepsy
Authors: S. Livingston
Journal: JAMA (1975)

OUR EXPERIENCE supports the findings of the Boston Collaborative Drug Surveillance Program, prepared by Jick,<sup>1</sup>which did not confirm the relationship of amphetamine therapy to the development of Hodgkin disease described by Newell et al.<sup>2</sup> Over the past 30 years, we have prescribed the amphetamines, primarily dextroamphetamine sulfate (Dexedrine), to at least 10,000 epileptic patients and are impressed with their singular freedom from untoward reactions. Some of these patients have taken with impunity an amphetamine daily for periods ranging from 20 to 30 years. It is noteworthy that we have not observed the occurrence of lymphadenopathy, pseudolymphoma, lymphocytic or lymphoblastic lymphosarcoma, or Hodgkin disease in any of our patients receiving amphetamines during this period of time. We have also treated approximately 1,300 children with the hyperkinetic behavioral syndrome, including 400 without a concomitant seizure disorder, with daily amphetamine therapy. Prolonged follow-up study of this group did not disclose
A multicenter comparison of lovastatin and cholestyramine therapy for severe primary hypercholesterolemia. The Lovastatin Study Group III
Journal: JAMA (1988)

This study compares lovastatin and cholestyramine resin therapy in patients with severe primary hypercholesterolemia. Two hundred sixty-four patients on lipid-lowering diets were randomized equally to receive 12 g of cholestyramine resin, 20 mg of lovastatin, or 40 mg of lovastatin, each twice a day. The mean reductions among the three groups after 12 weeks' treatment in levels of total plasma cholesterol (-17%, -27%, and -34%, respectively) and low-density lipoprotein cholesterol (-23%, -32%, and -42%, respectively) and the median reductions in apolipoprotein B levels (-21%, -28%, and -33%, respectively) were all significantly different between groups. Similar mean increases in high-density lipoprotein cholesterol levels (8%, 9%, and 8%, respectively) and median increases in apolipoprotein A-1 levels (7%, 6%, and 11%, respectively) were observed in all treatment groups. Cholestyramine resin treatment had no significant effect on very low-density lipoprotein cholesterol and apolipoprotein A-II levels and produced a median 11% increase in plasma triglyceride concentration; in contrast, administration of either 20 or 40 mg of lovastatin twice a day was associated with median reductions in very low-density lipoprotein cholesterol levels (-34% and -31%, respectively) and plasma triglyceride levels (-21% and -27%, respectively) and median increases in levels of apolipoprotein A-II (8% and 13%, respectively). Adverse events in all treatment groups were preponderantly in the gastrointestinal tract; gastrointestinal tract symptoms that could be attributed to therapy with a specific drug occurred in 58% of the cholestyramine resin group, 13% of the 20-mg lovastatin group, and 14% of the 40-mg lovastatin group. The only drug-attributable serious adverse event was a reversible myopathy in a patient taking 40 mg of lovastatin twice a day. We conclude that lovastatin is both more effective and better tolerated than cholestyramine resin in the treatment of primary hypercholesterolemia.
Editorial: The quality of life in later years
Authors: Z. Danilevicius
Journal: JAMA (1974)

The life of senior citizens was the subject of the Third Congress on the Quality of Life held recently in Chicago. Among those attending the congress were physicians and nurses, sociologists and psychologists, and economists and educators. On one of the panels even the senior citizens themselves were represented. I happened to overhear one young participant say to another, "Imagine, all of these oldsters have at one time been young, like us." Such a shocking realization! Yes, old people are young people who have lived longer, whose outlook on life may have changed with time, as have their social and economic conditions. The point at which a person is considered old has not been set by biological criteria. Sixty-five has been declared —arbitrarily—the age of retirement, and the term "senior citizen" has been introduced to denote this fact. Statisticians say that by 1980 approximately 12% of the population of the
Pubic Osteomyelitis
Authors: M HAENTJENS, R ACHTEN, M VERLEOVEN, A PIEPSZ
Journal: Clinical Nuclear Medicine (1985)

A case of pubic osteomyelitis in a child is presented. A well localized hyperactive area on a Tc-99m MDP bone scan provided the correct diagnosis. This scintigraphic localization of osteomyelitis seldom has been reported.
Bolivian Hemorrhagic Fever—EI Beni Department, Bolivia, 1994
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GENEVA
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prion Disease
Authors: Richard T. Johnson
Journal: New England Journal of Medicine (1992)

1 FIRST heard of scrapie, the prototype spongiform encephalopathy also known as prion disease, at a conference at Wye College in England in 1962. J.T. Stamp, of the Moredun Institute of Edinburgh, presented data on the serial transmission and replication of the infectious agent of this chronic neurologic disease of sheep. H.B. Parry of the Nuffield Institute of Oxford then showed data on carefully studied flocks that indicated that scrapie was an inherited degenerative disease caused by a single autosomal recessive gene. Most if not all of us in the audience were bewildered. Were they studying the same disease? Now, . . .
Predicting coronary heart disease
Authors: F. H. Epstein
Journal: JAMA (1967)

The probability of the development of coronary heart disease can now be defined with considerable accuracy. The probability of the development of clinical disease in middle-aged men with various combinations of risk factors in the upper range is somewhere between one and two chances in five within a ten-year period. When such men are compared with others in the lower ranges of these variables, their excessive risk is of the order of threefold to tenfold, depending on the selection of predisposing factors and the choice of dividing points between "positive" and "negative" test results. Determining the need for preventive measures in a given individual has, therefore, become a matter of rational and quantitative assessment rather than a decision based on an informed and intelligent guess.
Re: Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim. Diagnostic Performance of Magnetic Resonance Imaging for the Detection of Bone Metastasis in Prostate Cancer: A Systematic Review and Meta-analysis. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2017.03.042
Authors: Thorsten Derlin, Christoph-A. von Klot, Katja Hueper
Journal: European Urology (2017)
TRANSMUTATION OF EVIL
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LAW AND MEDICINE
Authors: Edwin J. Holman
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PATHOGENESIS OF HYPERTENSIVE ARTERIAL NECROSIS
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19723: Troponin Elevations in Ischemic Stroke are Associated With Stroke Severity and Advanced Age
Authors: Benjamin R Miller, Ayham M.Alkhachroum, Tarek Chami, Cathy Sila
Journal: Circulation (2015)

Introduction: Troponin elevations are common in patients with hemorrhagic stroke where they have been attributed to sympathomimetic states and stroke severity. Troponin elevations are less common in patients with ischemic stroke and have been associated with insular cortex location but there are no studies evaluating the impact of stroke severity. The diagnosis of type II MI/ myocardial strain is a co-morbidity that increases case-mix index and impacts DRG assignment. Hypothesis: Troponin elevations in ischemic stroke is related to stroke severity and older age, independent of severity. Methods: All patients with ischemic stroke at University Hospitals Case Medical Center from January 2014 to April 2015 were retrospectively reviewed. Data was collected on demographics, stroke severity by National Institutes of Health Stroke Score (NIHSS), and serial troponin values. Results: Of 629 patients with ischemic stroke, 478 met inclusion criteria including initial and follow up troponin levels. Elevated troponin levels were found in 28.2% of patients- 16.3% in high and 11.9% in critical ranges. Troponin elevations were associated with stroke severity. Although initial troponin values were not significantly different for the more severe ischemic strokes (NIHSS ≥ 10) vs less severe (NIHSS &lt;10) for the initial troponin value, they were significantly higher on follow up values (p&lt;0.001). This was more apparent when stratified by age; initial and peak troponin values increased in both age groups, more for those ≥65 (p=0.0003), but was observed for younger patients as well (&lt;65, p=0.03). Conclusions: Elevated troponin levels occur in 28.2% of patients with ischemic stroke, 11.9% in the critical range, and are associated with higher stroke severity and advanced age. Patients with more severe stroke and advanced age are more likely to have troponin elevations on follow up testing thus a baseline value alone may not be sufficient to assess risk or establish the cardiac diagnosis.
Long-Term Safety and Efficacy of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Mantle Cell Lymphoma: A Multicenter, Open-Label, Phase II Study
Authors: Yuqin Song, Yongping Song, Lihong Liu, Mingzhi Zhang, Zhiming Li, Chunyan Ji, Wei Xu, Ting Liu, Bing Xu, Xin Wang, Sujun Gao, Huilai Zhang, Yu Hu, Yan Li, Ying Cheng, Haiyan Yang, Junning Cao, Zunmin Zhu, Jianda Hu, Wei Zhang, Hongmei Jing, Kaiyang Ding, Zhengguang Lu, Bin Zhang, Renbin Zhao, Zhixin Xu, Jun Zhu
Journal: Blood (2020)
ERRATUM
Journal: Journal of Clinical Oncology (2007)

In the Patients and Methods section, under Statistical Analyses, the description of the initial multivariate models was given as:"Multivariate models initially included the following dependent variables: age, sex, hypertension (yes/no), diabetes (yes/no), low-density lipoprotein and high-density lipoprotein cholesterol, smoking history (yes/no), chemotherapy (yes/no), irradiation dose in BED, and time after irradiation.Variables were removed from the model sequentially, until only those variables that were predictors (P Ͻ .05) of the independent variable remained."While it should have read: "Multivariate models initially included the following independent variables: age, sex, hypertension (yes/no), diabetes (yes/no), low-density lipoprotein and high-density lipoprotein cholesterol, smoking history (yes/no), chemotherapy (yes/no), irradiation dose in BED, and time after irradiation.Variables were removed from the model sequentially, until only those variables that were predictors (P Ͻ .05) of the dependent variable remained."
Book Review Biological Symposia: A series of volumes devoted to current symposia in the field of biology . Edited by Jaques Cattell, Ph.D. Vol. VII. Visual Mechanisms. Edited by Heinrich Klüver, Ph.D. 8°, cloth, 322 pp., with 4 tables and 83 illustrations. Lancaster, Pennsylvania: The Jaques Cattell Press, 1942. $3.25.
Journal: New England Journal of Medicine (1943)