tbuckley/cabot-search huggingface dataset:
Consumer Hazards of Plastics
Authors: G. S. Wiberg
Journal: Environmental Health Perspectives (1976)

The modern consumer is exposed to a wide variety of plastic and rubber products in his day to day life: at home, work, school, shopping, recreation and play, and transport. A large variety of toxic sequellae have resulted from untoward exposures by many different routes: oral, dermal, inhalation, and parenteral. Toxic change may result from the plastic itself, migration of unbound components and additives, chemical decomposition or toxic pyrolysis products. The type of damage may involve acute poisoning, chronic organ damage, reproductive disorders, and carcinogenic, mutagenic and teratogenic episodes. Typical examples for all routes are cited along with the activites of Canadian regulatory agencies to reduce both the incidence and severity of plastic-induced disease.
New Guidelines for Residency Programs
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Constantin von Monakow (1853-1930) Neurobiologic Philosopher
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the NIH: leaving the hospital against medical advice
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
African American Women More Likely to Die of Triple-Negative Breast Cancer
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician Recruitment Advertising
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphedema Tarda
Authors: Jack Segal
Journal: JAMA (1976)

The clinical recognition and evaluation of congenital lymphedema of the lower extremities with abrupt onset in a 51-year-old man are reviewed. A rational, systematic approach is outlined and exemplifies the use of an interdisciplinary effort to achieve accurate diagnosis through readily available diagnostic procedures. (<i>JAMA</i>235:1996-1997, 1976)
Medical interpreting for hearing-impaired patients
Authors: G. Reisman
Journal: JAMA (1977)

Medical interpreting for deaf patients is a new dimension of the medical field. Medical interpreting allows for the fast, accurate, and complete exchange of medical information between medical professionals and their deaf patients. The exchange of accurate medical information is critical to the early diagnosis and treatment of medical problems. (<i>JAMA</i>237:2397-2398, 1977)
Decisions to abate life-sustaining treatment for nonautonomous patients. Ethical standards and legal liability for physicians after Cruzan
Authors: R. F. Weir
Journal: JAMA (1990)

PHYSICIANS often feel impelled to initiate and continue the complete range of modern medical procedures to prolong the lives of critically ill patients. A tragic consequence is that patients who lack decision-making capacity are sometimes given life-sustaining treatment that is not consistent with the patients' previous preferences, not in the patients' best interests, and not wanted by their families. Why are such cases sometimes handled this way? The reasons are multiple. First, cases involving adult patients who lack decision-making capacity often have medical and nonmedical uncertainties not commonly present in other cases. Some of the uncertainty concerns the questionable decision-making status of patients who have a diminished or fluctuating capacity to make health care decisions because of shock, mental illness, clinical depression, or organic brain syndrome. Other problems arise in cases with patients who have a substantial incapacity to make decisions because of mental retardation, brain damage, severe dementia, or
The impact of multimodality therapy in marginally inoperable soft tissue sarcomas (STS): The Toronto Sarcoma Program Experience.
Authors: Samer Salah, Anthony Lott, Peter Charles Ferguson, Jay Wunder, Abha A. Gupta, Charles N Catton, Brian O'Sullivan, Carol Jane Swallow, Peter W. M. Chung, Eitan Amir, Albiruni R Abdul Razak
Journal: Journal of Clinical Oncology (2016)

11051 Background: Our study assessed outcomes and factors predicting survival following initiation of multi-modality therapy for marginally inoperable STS patients (pts). Methods: A retrospective review of sequential pts deemed to have marginally inoperable STS at our tumor board was conducted. All pts must have had chemotherapy with the intention to be followed by radiation and surgery. Relapse free survival (RFS) and overall survival (OS) were estimated using the Kaplan-Meier method. The influence of disease characteristics and treatment on outcome was assessed using Cox regression. Results: Fifty- two pts (median age of 53) were included. Main histological subtypes were leiomyosarcoma (25%), liposarcoma, and synovial sarcoma (23% each). Disease was confined to extremity in 14 pts (27%), thorax in 8 (15%), abdo-pelvis in 25 (48%), and in combined locations in 5 (10%). All pts had doxorubicin/ifosfamide chemotherapy (mean cycle no. = 4.0). Six pts (11.5%) had progression during chemotherapy and did not undergo radiation or surgery. Nine patients (17.3%) underwent chemotherapy and surgery without radiation due to significant response with chemotherapy or concerns about radiation toxicity. Three patients (5.8%) underwent chemotherapy and radiation without surgery due to persistent unresectability of the tumour. The final 34 patients (65.4%) underwent both radiation and surgery after chemotherapy. Overall, 43 pts (83%) had surgery, negative margins were achieved in 41 (79%). With a median follow up of 26 months, median OS and RFS was 52 and 26 months respectively. Extremity location predicted superior RFS (HR 0.19, p = 0.009), and OS (HR 0.22, p = 0.02). The absence of radiotherapy predicted inferior RFS (HR 0.26, p = 0.005) and histology had significant effect on RFS (p = 0.04) with dedifferentiated liposarcomas having the worse outcome whereas synovial sarcomas having a more favorable outcome. Conclusions: Multimodality approach results in successful resection in most pts with marginally inoperable STS. Extremity location has a favorable impact on RFS and OS, while administration of radiotherapy and histological subtypes were predictors of RFS in our series.
LIGHT ON SHAKESPEARE’S MEDICAL INFORMATION
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SCHOOL DIPHTHERIA AND THE GERM-CARRIER
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interleukin 1β inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance
Authors: Eric Assenat, Sabine Gerbal-Chaloin, Dominique Larrey, Jean Saric, Jean-Michel Fabre, Patrick Maurel, Marie-José Vilarem, Jean Marc Pascussi
Journal: Hepatology (2004)

During the inflammatory response, intrahepatic cholestasis and decreased drug metabolism are frequently observed. At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin. We investigated the negative regulation of CAR, a glucocorticoid-responsive gene, via proinflammatory cytokine interleukin 1β (IL-1β) and lipopolysaccharides (LPSs) in human hepatocytes. We show that IL-1β decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA. This occurs via nuclear factor κB (NF-κB) p65 activation, which interferes with the enhancer function of the distal glucocorticoid response element that we have identified recently in the CAR promoter. We demonstrate that: (1) LPSs, IL-1β, or overexpression of p65RelA inhibit glucocorticoid receptor (GR)-mediated CAR transactivation; (2) these suppressive effects can be blocked both by pyrrolidine dithiocarbamate, an inhibitor of NF-κB activation, or by overexpression of SRIkBα, a NF-κB repressor; and (3) the GR agonist dexamethasone induces histone H4 acetylation at the proximal CAR promoter region, whereas LPSs and IL-1β inhibit this acetylation as assessed via chromatin immunoprecipitation assay. In conclusion, GR/NF-κB interaction affects CAR gene transcription through chromatin remodeling and provide a mechanistic explanation for the long-standing observation that inflammation and sepsis inhibit drug metabolism while inducing intrahepatic cholestasis or hyperbilirubinemia. Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html). (HEPATOLOGY 2004.)
Surface Reactivity in the Pathogenic Response to Particulates
Authors: Bice Fubini
Journal: Environmental Health Perspectives (1997)

The peculiar characteristics of dust toxicity are discussed in relation to the processes taking place at the particle-biological medium interface.Because of surface reactivity, toxicity of solids is not merely predictable from chemical composition and molecular structure, as with water soluble compounds.With particles having the same bulk composition, micromorphology (the thermal and mechanical history of dust and adsorption from the environment) determines the kind and abundance of active surface sites, thus modulating reactivity toward cells and tissues.The quantitative evaluation of doses is discussed in comparisons of dose-response relationships obtained with different materials.Responses related to the surface of the particle are better compared on a per-unit surface than per-unit weight basis.The role of micromorphology, hydrophilicity, and reactive surface cations in determining the pathogenicity of inhaled particles is described with reference to silica and asbestos toxicity.Heating crystalline silica decreases hydrophilicity, with consequent modifications in membranolytic potential, retention, and transport.Transition metal ions exposed at the surface generate free radicals in aqueous suspensions.Continuous redox cycling of iron, with consequent activation-reactivation of the surface sites releasing free radicals, could account for the long-term pathogenicity caused by the inhalation of iron-containing fibers.In various pathogenicities caused by mixed dusts, the contact between components modifies toxicity.Hard metal lung disease is caused by exposure to mixtures of metals and carbides, typically cobalt (Co) and tungsten carbide (WC), but not to single components.Toxicity stems from reactive oxygen species generation in a mechanism involving both Co metal and WC in mutual contact.A relationship between the extent of water adsorption and biopersistence is proposed for vitreous fibers.Modifications of the surface taking place in vivo are described for ferruginous bodies and for the progressive comminution of chrysotile asbestos fibers.
Phase II trial of eribulin and S-1 combination therapy for advanced or recurrent breast cancer
Authors: T. Iwasa, J. Tsurutani, Y. Mizuno, Y. Kojima, T. Takashima, N. Matsunami, T. Morimoto, J. Yamamura, S. Ohtani, Y. Tanabe, S. Watanabe, R. Kato, H. Tanino, S. Tokunaga, H. Abe, S.T. Tsuyuki, F. Hara, T. Takano, Y. Komoike, K. Nakagawa
Journal: Annals of Oncology (2017)
Silver anniversary celebrated for Penn State heart
Authors: M. F. Goldsmith
Journal: JAMA (1995)

A TRIBUTE to persistence and delivery of paeans of praise for a man one of his sons affectionately called "the Grand Pooh-Bah of artificial heart surgery" took place at the Milton S. Hershey Medical Center in Hershey, Pa, in May. William S. Pierce, MD, was honored at a symposium, "The Artificial Heart: Past, Present, and Future—Celebrating 25 Years at Penn State." During the 2-day gathering, investigators from around the United States and other countries who have played prominent roles in developing the Penn State Heart (<i>JAMA</i>. 1985;253:2617-2621 and 1993:269:966-973) and other pioneering artificial organ parts and systems looked back at the brave (if somewhat naive) beginnings of their discipline, assessed where they are now, and predicted an expanding future for fabricated bits of human beings. Currently, the Penn State model is one of two air-driven devices the Food and Drug Administration has approved for use as a bridge to transplantation.
Clinical Pediatric Oncology
Authors: Ruth Andrea Seeler
Journal: JAMA (1978)

The second edition of<i>Clinical Pediatric Oncology</i>just four years after the first edition attests to the explosive expansion of knowledge within the field. The second edition is 25% larger with nearly 50% more illustrations. As with the first edition, each chapter is an authoritative, complete discussion. Roughly one third of the text is devoted to the overall aspects of pediatric oncology, diagnostic modalities, theoretical concepts for therapy, and the principles of total care. The remainder of the book discusses specific tumor entities. In the general aspect sections, one finds three chapters devoted to incidence, etiology, genetics, environmental factors, and other factors as related to pediatric malignant neoplasms. A nearly overwhelming amount of factual data is compressed into these well-indexed and well-organized first 45 pages. There are three chapters devoted to pediatric radiology. The chapter dealing with ultrasound and angiograms is particularly well illustrated by selective case studies. An entirely
Christmas Carols
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal