tbuckley/cabot-search huggingface dataset:
Carcinogenicity of Oil Shale Tars, Some of Their Components, and Commercial Products
Authors: P. A. Bogovski, F. Vinkmann
Journal: Environmental Health Perspectives (1979)

Bioassays for carcinogenicity of various primary processing products (crude oils or tars) and commercial products obtained from Estorian oil shale have been carried out since 1951. The products (undiluted or diluted) were painted twice weekly 50 times on the interscapular area of the skin of random-bred or CC57Br mice. The products processed at high temperatures have a higher carcinogenic activity. Blends of products containing over 10% of high temperature crude oil (chamber furnace oil) have about the same carcinogenic activity as the latter. There is no strict correlation between the concentration of benzo(a)pyrene (BP) in oil shale products and their carcinogenic activity. Determination of BP in such products can serve as an approximate estimate of carcinogenic properties. The results of animal experiments with chromatographic fractions of the high temperature shale oil demonstrated the presence of compounds which lengthen the latency period of the carcinogenic effect of BP in the aromatic fraction of this oil as well as other carcinogens and compounds enhancing the activity of carcinogenic compounds. Under industrial conditions, contact of workers with carcinogenic shale oils can be reduced by means of coking the carcinogenic oils, which results in production of solid coke and of distillate which is recycled. Medical vaseline potentiates the carcinogenic action of BP and similar compounds. Dilution of shale oils with oils containing aliphatic hydrocarbons cannot be considered as diminution of the carcinogenic potency of these products.
THE MORBID ANATOMY OF PROGRESSIVE MUSCULAR DYSTROPHY.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuro-cognitive
Authors: S. H. O'Neil, J. Azoff, C. Buranahirun, G. Dhall, A. Panigrahy, M. Borchert, S. Khatua, L. Ji, R. Sposto, J. Finlay, X. Gong, P. Schwartz, M. Linskey, D. A. Bota, J. S. Wefel, S. Y. Patwardhan, C. Strange, F. Emily, A. Celine, K. Penelope, C. Anne-Sophie, D. M. Rolando, P. Michael, D. D. Correa, W. Shi, L. Abrey, L. DeAngelis, H. Thaler, E. J. Habets, R. Walchenbach, A. Kloet, H. Zwinkels, M. Klein, C. J. Vecht, M. J. Taphoorn, N. Ambachtsheer, D. van Nieuwenhuizen, J. J. Heimans, J. C. Reijneveld, S. M. Peerdeman, M. Klein, D. van Nieuwenhuizen, C. Lagemaat, J. J. Heimans, S. M. Peerdeman, M. Klein, J. C. Reijneveld, K. B. Peters, D. A. Reardon, J. J. Vredenburgh, A. Desjardins, H. S. Friedman, P. H. Driever, E. Koustenis, G. Henze, L. De Sonneville, S. M. Rueckriegel, K. Mok, D. Klein, R. Del Maestro, K. Petrecca, A. Olivier, B. D. Schanker, W. T. Curry, K. Edelstein, B. J. Spiegler, S. Fung, T. Panzarella, D. C. Hodgson, D. J. Mabbott, N. Laperriere, U. Tabori, E. Bouffet, W. P. Mason
Journal: Neuro-Oncology (2010)
Histologie und mikroskopische Anatomie des Menschen mit Berücksichtigung der Histophysiologie und der mikroskopischen Diagnostik
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leuprolide versus Diethylstilbestrol for Metastatic Prostate Cancer
Journal: New England Journal of Medicine (1984)

We compared the efficacy and safety of the gonadotropin-releasing hormone analogue, leuprolide (1 mg subcutaneously daily), with diethylstilbestrol (DES, 3 mg by mouth daily) in patients with prostate cancer and distant metastases (Stage D2) who had not previously received systemic treatment. Initial therapy (leuprolide or DES) was continued for as long as an objective response was noted; cross-over to the alternative arm occurred at the time of disease progression or intolerable adverse reactions. Ninety-eight patients were randomly assigned to leuprolide, and 101 to DES. Suppression of testosterone and dihydrotestosterone and decreases in acid phosphatase were comparable in the two groups. Patients receiving DES experienced more frequent painful gynecomastia (P less than 0.00001), nausea and vomiting (P = 0.02), edema (P = 0.008), and thromboembolism (P = 0.065) than those receiving leuprolide. The leuprolide group reported more "hot flashes" (P = 0.00001). Overall, 86 per cent of the leuprolide group had an objective response (complete response, 1 per cent; partial response, 37 per cent; stable disease, 48 per cent), as compared with 85 per cent of the DES group (complete, 2 per cent; partial, 44 per cent; stable, 39 per cent). Actual survival rates at one year were 87 per cent for the leuprolide group and 78 per cent for the DES group (P = 0.17). We conclude that leuprolide offers an important alternative treatment that is therapeutically equivalent to and causes fewer side effects than DES for the initial systemic management of metastatic prostate cancer.
Electrocardiography
Authors: Arthur J. Moss
Journal: JAMA (1967)

The author has developed a very successful programmed electrocardiographic text. The reader participates actively in the learning process through a group of scrambled, multiple-choice questions as well as questions requiring constructed responses. The overall effect is an enjoyable learning experience. The fundamental of electrocardiography are well presented, and the sequential approach from basic concepts of electrocardiography to disorders of cardiac rhythm flows smoothly. The author has utilized a modified Grant approach in the preliminary sections dealing with leads, and a pattern orientation in the subsequent parts. The section on myocardial infarction could have been longer. Although Dr. Owen hails from across the Atlantic at Newcastle upon Tyne, terminology is fully acceptable for American students. The printing is good, and the electrocardiograms are clearly presented and reproduced. This excellent programmed text is highly recommended to many audiences. Medical students will be delighted by the way Dr. Owen has developed a more
Murder a la Microbe.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MR. JONATHAN HUTCHINSON'S CLINICAL MUSEUM.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Surgery of the Kidneys
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impairment of tubuloglomerular feedback regulation of GFR in ecto-5′-nucleotidase/CD73–deficient mice
Authors: Hayo Castrop, Yuning Huang, Seiji Hashimoto, Diane Mizel, Pernille Hansen, Franziska Theilig, Sebastian Bachmann, Chuxia Deng, Josie Briggs, Jurgen Schnermann
Journal: Journal of Clinical Investigation (2004)

Adenosine coordinates organ metabolism and blood supply, and it modulates immune responses. In the kidney it mediates the vascular response elicited by changes in NaCl concentration in the macula densa region of the nephron, thereby serving as an important regulator of GFR. To determine whether adenosine formation depends on extracellular nucleotide hydrolysis, we studied NaCl-dependent GFR regulation (tubuloglomerular feedback) in mice with targeted deletion of ecto-5′-nucleotidase/CD73 (e-5′NT/CD73), the enzyme responsible for adenosine formation from AMP. e-5′NT/CD73–/– mice were viable and showed no gross anatomical abnormalities. Blood pressure, blood and urine chemistry, and renal blood flow were not different between e-5′NT/CD73+/+ and e-5′NT/CD73–/– mice. e-5′NT/CD73–/– mice had a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow. Furthermore, whereas tubuloglomerular feedback responses did not change significantly during prolonged loop of Henle perfusion in e-5′NT/CD73+/+ mice, a complete disappearance of the residual feedback response was noted in e-5′NT/CD73–/– mice over 10 minutes of perfusion. The contractile response of isolated afferent arterioles to adenosine was normal in e-5′NT/CD73–/– mice. We conclude that the generation of adenosine at the glomerular pole depends to a major extent on e-5′NT/CD73–mediated dephosphorylation of 5′-AMP, presumably generated from released ATP.
Weight change since age 18 years in 30- to 55-year-old whites and blacks. Associations with lipid values, lipoprotein levels, and blood pressure
Authors: P. Khoury
Journal: JAMA (1983)

To assess associations between current weight, weight at age 18 years, and weight change from age 18 years to ages 30 to 55 years with current levels of plasma cholesterol (C), high- and low-density lipoprotein C (HDLC and LDLC), triglycerides (TG), and systolic and diastolic BP (SBP and DBP), we calculated weight change from self-reported weight at age 18 years and measured weight at ages 30 to 55 years in 308 white and 69 black subjects in a random recall group and 244 whites and 66 blacks in a hyperlipidemic recall group in the Princeton School Study. In randomrecall-group whites, mean weight gain over time was greater in men than in women; black women had greater weight gain than black men, and nearly twice the weight gain of white women. Current weight and/or weight gain from age 18 years to ages 30 to 55 years in whites were inversely associated with HDLC level and positively associated with TG level, SBP, and DBP. Similar, but less consistent and significant, trends were observed for blacks. Although weight at age 18 years had no consistent independent explanatory relationship to C, TG, HDLC, and LDLC values, random-recall-group white men who were in the lowest quartile for weight at age 18 years had current levels of C, TG, SBP, and DBP that were all lower than those observed in white men who had been in the upper quartile of weight at age 18 years. Atherogenic increments in TG levels, SBP, and DBP from age 18 years to ages 30 to 55 years are a function, in part, of weight gain during these years. (<i>JAMA</i>1983;250:3179-3187)
From the Authors
Authors: J.M. Shneerson, A.K. Simonds
Journal: European Respiratory Journal (2004)

Noninvasive ventilation or paradigm paralysis?To the Editor:Current respiratory management paradigms recommend tracheotomy for ventilator-dependent patients.The review by SHNEERSON and SIMONDS [1] published in the European Respiratory Journal on the current use of noninvasive ventilation (NIV) in neuromuscular disorders does little to dispel this paradigm.The authors note that "nasal and face masks are usually the first choice" for NIV interfaces, and they further note that randomised controlled trials are needed to determine outcomes for NIV and in-exsufflation, particularly in amyotrophic lateral sclerosis.The authors seem to be
Indium in 113m for visualizing body organs. A broad spectrum scanning agent
Authors: E. J. Potchen
Journal: JAMA (1968)

Indium In 113m, a generator-produced radionuclide, has been useful as a protein-bound metal and a colloidal aggregate to scan the cardiac blood pool, placenta, liver, spleen, bone marrow, lung, and brain. The wide applicability and ease of preparation in addition to the physical characteristics of this radiopharmaceutical suggest that it may well be the most useful scanning agent devised to date.
Deficiency of the Fas apoptosis pathway without Fas gene mutations is a familial trait predisposing to development of autoimmune diseases and cancer
Authors: Ugo Ramenghi, Sara Bonissoni, Giuseppe Migliaretti, Simona DeFranco, Flavia Bottarel, Caterina Gambaruto, Daniela DiFranco, Roberta Priori, Fabrizio Conti, Irma Dianzani, Guido Valesini, Franco Merletti, Umberto Dianzani
Journal: Blood (2000)
Extracorporeal membrane oxygenation for acute respiratory failure
Authors: R. C. Bone
Journal: JAMA (1986)

The adult respiratory distress syndrome was described as a clinical entity in 1967.1<sup>1</sup>The mortality in early reports was as high as 70%. This was disappointing since the entity was shown to be common (estimated as high as 150 000 per year in the United States), and potentially reversible. During this time intensive care units were using the most sophisticated technology and the National Institutes of Health sponsored a randomized multicenter trial of extracorporal membrane oxygenation (ECMO) in the hope that this advanced technology might improve survival. The results were discouraging; survival was not improved.<sup>2</sup>This negative study was an important contribution to the literature since if the ECMO study had been positive, every center treating these patients would be using this costly and labor-intensive therapy. A negative study thus introduced the second phase, the study of basic mechanisms of lung injury in this condition and experimentation in
Clinical overlap among medical diagnosis-related groups
Authors: L. I. Iezzoni
Journal: JAMA (1986)

EVER since Congress enacted the hospital prospective payment system for Medicare in 1983, diagnostic semantics have come under increasing scrutiny. Under this reimbursement method, hospitals are paid a single, predetermined sum based on the patient's diagnosis-related group (DRG). The DRG system sorts the realm of "diagnoses" into 467 groups. However, the term<i>diagnosis</i>may be a misnomer. Some of the DRGs may be more appropriately called "symptom-related groups"—chest pain (DRG 143), for example. Others may be labeled "pathology-related groups" (atherosclerosis, DRGs 132 and 133), while still others may be best titled "severity-related groups" (heart failure and shock, DRG 127). This quibbling over the diagnostic lexicon may appear a trivial exercise unless one remembers that the DRG assignment dictates level of reimbursement. Each of the 467 DRGs has its own nationwide relative weight (RW) for reimbursement. Therefore, pecuniary incentives encourage close inspection of diagnostic phrasing to ensure patient allocation to the
Eddie Q
Authors: Andrew D. Mitchell
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: G Kleber, T Sauerbruch, G Fischer, G Paumgartner
Journal: Gut (1988)

Somatostatin on intravariceal pressure SIR,-We read with interest the article on the effects of somatostatin on intravariceal pressure in patients with cirrhosis and portal hypertension (Kleber G, et al, Gut 1988; 29: 153-6).We were not surprised, however, that the investigators failed to observe any change in intravariceal pressure or systemic haemo- dynamics 2-5 to six minutes after administration of a bolus dose of somatostatin.In our experience, the reduction in intravariceal pressure,' portal pressure' or wedged hepatic venous pressure (WHVP)2 in patients with cirrhosis and portal hypertension occurs within five to 10 seconds after bolus administration of somatostatin or SMS 201-995.The reduction in intravariceal pressure or WHVP after bolus adminis- tration of somatostatin or SMS 201-995 is followed approximately 20-30 seconds later by a small but significant increase in arterial blood pressure and a bradycardia, suggesting that the systemic changes are secondary to the effects on splanchnic haemo- dynamics.Furthermore, the effects of a bolus dose of somatostatin and its analogue on splanchnic and hepatic haemodynamics are transient, the values returning to normal within two minutes after com- pletion of the administration.Consequently, Kleber and his colleagues, by measuring intravariceal pressure 2-5 to six minutes after bolus administration of somatostatin would have missed any response.We find it surprising that knowing that the biological half life of somatostatin is very short, and if Fig. 1 is correct, each measurement of intravariceal pressure took approximately two minutes to, record, the
SPECIALISM AND SCIENTIFIC SUCCESS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and cystatin C as markers of mild kidney function impairment in patients with liver cirrhosis
Authors: Anna Szymanek-Pasternak, Sylwia Serafińska, Monika Pazgan-Simon, Justyna Janocha-Litwin, Jolanta Zuwała-Jagiełło, Ewa Grzebyk, Simon Krzysztof
Journal: Journal of Hepatology (2020)