tbuckley/cabot-search huggingface dataset:
Road accidents and the police.
Journal: BMJ (1979)

surgeons), who would no doubt be happy to co-operate.In one town the surgeon in charge of the accident unit gave police officers tuition in airway control at the hospital, and this was greatly appreciated.Equipment of most police cars was inadequate and often consisted only of first- aid boxes containing bandages and dressings.Patrol cars attending road accidents should have modern respiratory resuscitation equip- ment, spinal boards, cervical collars, inflatable splints, and waterproof sheets.They should also carry light rescue and cutting equipment for the release of trapped casualties, particu- larly in rural districts.
M.R.C.P. (U.K.)
Authors: M Regulations, G Mathe, Thomas Holmes Sellors, D.-M Clark, Eva Kohner, B Bush, H Bussey, R Saeed-Ul, R Haque, J Tripathi, A Wilson, S.-R Al-Mallah, R Kilhick-Kendrick, Jean Woods, Nuala Crowley
Journal: BMJ (1970)
Book Review Bailey's Text-Book of Histology . By Philip E. Smith, Ph.D., Russell L. Carpenter, Ph.D., Wilfred M. Copenhaver, Ph.D., Charles M. Goss, M.D., and Aura E. Severinghaus, Ph.D. Tenth edition. 8°, cloth, 764 pp., with 448 illustrations. Baltimore: Williams and Wilkins Company, 1940. $6.00.
Journal: New England Journal of Medicine (1941)
Staffing crisis in pathology
Authors: R P Lindley
Journal: BMJ (1981)

clopenthixol decanoate using the therapeutic regimen described did not show any extra- pyramidal side effects.A small minority required treatment with anti-Parkinson drugs, which controlled these side effects.The clinically useful calming and behaviourmodifying effects of clopenthixol decanoate in this small group of patients suggest that further study of clopenthixol as an aid to the management of the behavioural problems associated with mental handicap is merited in a larger group of such patients.
Summary of Veterinary Surgeons' discussion
Journal: British Journal of Sports Medicine (1976)

Interpretation of Rules of Racing & Interpretation of positive resultsThere was the suggestion that a copy of the national rules concerning the control of doping should be exchanged between the countries participating at this symposium.I consider this could best be dealt with by various secretariats and it could go as a recommendation from this symposium to the various secretariats of the racing authorities.Clinical examination and reporting on the clinical or physical appearance of the horse which is subject to a dope test
Chronic Chlamydia trachomatis infections in infants
Authors: T. A. Bell
Journal: JAMA (1992)

<h3>Objective.</h3> —To study the natural history of<i>Chlamydia trachomatis</i>infections in infants. <h3>Design.</h3> —Bacteriologic and serologic study of an inception cohort. <h3>Setting.</h3> —University of Washington Medical Center, Seattle. <h3>Participants.</h3> —Twenty-two infants with<i>C trachomatis</i>infections either not treated early in life or recurring after antimicrobial treatment. <h3>Main Outcome Measures.</h3> —Persistence of infection in various anatomic sites, antibody responses to specific serovars (serologic variants) of<i>C trachomatis</i>, and serovars of isolates from mothers and infants. <h3>Results.</h3> —The cumulative proportion of infants still infected at the age of 1 year was 35%. Infection persisted in the conjunctiva, nasopharynx, and oropharynx in one child for as long as 866 days (28.5 months), when she was cured by treatment. In none of the infants did serologic tests suggest acquisition of infection other than at birth. Isolates of<i>C trachomatis</i>from mothers and their respective infants were always of the same serovar. <h3>Conclusions.</h3> —Many infants infected with<i>C trachomatis</i>at birth remain infected for months or years in the absence of specific antimicrobial therapy. Such infections may be confused with those acquired by sexual abuse. (<i>JAMA</i>. 1992;267:400-402)
Highlights
Journal: JAMA (2018)

Medicare Spending on Brand-name Combination Drugs 650Brand-name combinations can be more expensive than their components, particularly when the components are available as low-cost generic drugs.In an analysis of Medicare data, Sacks and colleagues estimated that spending for 29 brand-name combinations was $922 million greater than the cost of the generic components. CME jamanetwork.com/learning Cardiovascular Health and Cognitive Decline 657Hypertension, dyslipidemia, obesity, and diabetes are risk factors for diseases affecting the heart and brain.Samieri and colleagues followed a population-based cohort of 6626 older adults and found that a higher cardiovascular health score was associated with lower risks of dementia and cognitive decline.In an Editorial on 2 studies in this issue, Saver and Cushman emphasize that it is never too early or too late to strive for ideal cardiovascular health.
Survival and disease progression according to gender of patients with HIV infection. The Terry Beirn Community Programs for Clinical Research on AIDS
Authors: S. L. Melnick
Journal: JAMA (1994)

<h3>Objective.</h3> —To compare disease progression and mortality between women and men infected with human immunodeficiency virus (HIV). <h3>Design.</h3> —Multicenter cohort. <h3>Setting.</h3> —Seventeen community-based centers participating in the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). <h3>Patients.</h3> —A total of 768 women and 3779 men enrolled in one or more of 11 protocols between September 7, 1990, and September 30, 1993. <h3>Main Outcome Measures.</h3> —Survival and opportunistic events. <h3>Results.</h3> —The median CD4<sup>+</sup>cell count at enrollment into the cohort was 0.240 ×10<sup>9</sup>/L (240/μL) for women and 0.137 ×10<sup>9</sup>/L for men (<i>P</i>&lt;.001). Compared with men, women were younger (36 vs 38 years), more likely to be African American or Hispanic (78% vs 44%), and more likely to have reported a history of injection drug use (49% vs 27%). Women had been followed up for a median of 14.5 months and men for 15.5 months. The adjusted relative risk (RR) for death among women compared with men was 1.33 (95% confidence interval [CI], 1.06 to 1.67;<i>P</i>=.01) and for disease progression (including death) was 0.97 (95% CI, 0.82 to 1.15;<i>P</i>=.72). Women were at increased risk for bacterial pneumonia (RR, 1.38; 95% CI, 1.05 to 1.92) and at reduced risk for the development of Kaposi's sarcoma (RR, 0.16; 95% CI, 0.04 to 0.65) and oral hairy leukoplakia (RR, 0.54; 95% CI, 0.31 to 0.94). The increased risk of death and bacterial pneumonia for women compared with men was primarily evident among those with a history of injection drug use (RR, 1.68 for death, 95% CI, 1.20 to 2.35,<i>P</i>=.003; RR, 1.53 for bacterial pneumonia, 95% CI, 1.03 to 2.29,<i>P</i>=.04). Among patients without a history of disease progression at entry, death was the first event reported for more women than men (27.5% vs 12.2%). <h3>Conclusions.</h3> —Compared with men, HIV-infected women in the CPCRA were at increased risk of death but not disease progression. Risks of most incident opportunistic diseases were similar for women and men; however, women were at an increased risk of bacterial pneumonia. These findings may reflect differential access to health care and standard treatments or different socioeconomic status and social support for women compared with men. (<i>JAMA</i>. 1994;272:1915-1921)
Finnish study confirms safety of MMR vaccine
Authors: Jacqui Wise
Journal: BMJ (2001)

Filarial nematodes, parasites of vertebrates, including humans, secrete immunomodulatory molecules into the host environment. We have previously demonstrated that one such molecule, the phosphorylcholine-containing glycoprotein ES-62, acts to bias the immune response toward an anti-inflammatory/Th2 phenotype that is conducive to both worm survival and host health. For example, although ES-62 initially induces macrophages to produce low levels of IL-12 and TNF-α, exposure to the parasite product ultimately renders the cells unable to produce these cytokines in response to classic stimulators such as LPS/IFN-γ. We have investigated the possibility that a TLR is involved in the recognition of ES-62 by target cells, because phosphorylcholine, a common pathogen-associated molecular pattern, appears to be responsible for many of the immunomodulatory properties of ES-62. We now demonstrate that ES-62-mediated, low level IL-12 and TNF-α production by macrophages and dendritic cells is abrogated in MyD88 and TLR4, but not TLR2, knockout, mice implicating TLR4 in the recognition of ES-62 by these cells and MyD88 in the transduction of the resulting intracellular signals. We also show that ES-62 inhibits IL-12 induction by TLR ligands other than LPS, bacterial lipopeptide (TLR2) and CpG (TLR9), via this TLR4-dependent pathway. Surprisingly, macrophages and dendritic cells from LPS-unresponsive, TLR4-mutant C3H/HeJ mice respond normally to ES-62. This is the first report to demonstrate that modulation of cytokine responses by a pathogen product can be abrogated in cells derived from TLR4 knockout, but not C3H/HeJ mice, suggesting the existence of a novel mechanism of TLR4-mediated immunomodulation.
Abstract 18070: Therapies Optimizing Organ Perfusion and Protection After Out-of-hospital Cardiac Arrest Improves Survival With Favorable Neurologic Outcome
Authors: Michael J Jacobs, Leo S Derevin, Sue Duval, James E Pointer, Karl A Sporer
Journal: Circulation (2015)

Introduction: Survival rates with favorable neurologic function after out-of-hospital cardiac arrest (OHCA) have remained low for decades. Hypothesis: Use of therapies focused on better perfusion during CPR using mechanical adjuncts and protective post-resuscitation care would improve survival and neurologic outcomes after OHCA compared to conventional CPR and care. Methods: OHCA outcomes in Alameda County, CA, USA, population 1.5 million, from December 2009-2011 when there was incomplete availability and use of impedance threshold device [ITD], mechanical CPR [MCPR], and hospital therapeutic hypothermia [HTH], were compared to 2012 when all were available and more widely used. Return of Spontaneous Circulation (ROSC), survival and Cerebral Performance Category (CPC) scores were compared using univariate and multivariable analyses. Results: Of the 3008 non-traumatic OHCAs who received CPR during the study period, &gt;95% of survival outcome data were available. From 2009-11 to 2012, there was an increase in ROSC from 28.6% to 34.1% (p=0.002; OR=1.28; CI=1.09, 1.51) and a non-significant increase in hospital discharge from 10.5% to 12.3% (p=0.14; OR=1.17; CI=0.92, 1.49). There was, however, an 80% increase in survival with favorable neurological function between the two periods, as determined by CPC≤2, from 4.4% to 7.9% (p&lt;0.001; unadjusted OR=1.85; CI=1.35, 2.54). After adjusting for witnessed arrest, bystander CPR, initial rhythm (VT/VF vs. others), placement of an advanced airway, EMS response time, and age, the adjusted OR was 1.60 (1.11, 2.31; p=0.012). Using a stepwise regression model, the most important independent positive predictors of CPC≤2 were 2012 (p=0.019), witnessed (p&lt;0.001), initial rhythm VT/VF (p&lt;0.001), and advanced airway (inverse association p&lt;0.001). Additional analyses of the three therapies, separately and in combination, demonstrated that for all patients admitted to the hospital, ITD use with HTH had the most impact on survival to discharge with CPC≤2 of 24%. Conclusions: Therapies (ITD, MCPR, HTH) developed to enhance circulation during CPR and cerebral recovery after ROSC, significantly improved survival with favorable neurological function by 80% following OHCA.
Errata
Journal: CA A Cancer Journal for Clinicians (2003)

appeared in the text on page 175.The statement which read: ''Follow-up after 20 years revealed a 39 percent recurrence rate for those receiving the adjuvant irradiation and 14 percent in those who did not.''was printed incorrectly.The statement should have read: ''Follow-up after 20 years revealed a 14 percent recurrence rate for those receiving the adjuvant irradiation and 39 percent in those who did not.''We apologize for this error and any confusion it may have caused.
Community Needs Assessment and Morbidity Surveillance Following an Ice Storm--Maine, January 1998
Journal: JAMA (1998)

On January 7,1998, an ice storm struck the northeastern United States and southeastern Canada. In Maine, 3 consecutive days of rain combined with ground temperatures consistently below freezing resulted in heavy accumulations of ice on trees and electric power lines. Falling trees and branches and breaking utility poles resulted in the loss of electrical power to an estimated 600,000 persons. Although the rain had stopped by January 11, temperatures declined to < 10 F (<-12 C) over most of the state, exacerbating the danger. On January 16, an estimated 50,000 households, primarily in the interior portion of the state, remained without power. This report summarizes a community needs assessment and a study of emergency department (ED) visits conducted during the aftermath of this storm.
Pharmaceutical dissolution of gallstones
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORRECTION
Journal: American Journal of Psychiatry (2019)

using depot forms of naltrexone achieve substantially lower peak blood levels of naltrexone and its active metabolite, b-naltrexol, compared with oral naltrexone (10).There is some debate regarding the minimal plasma naltrexone levels required to block the subjective effect of intravenous heroin (10-13).However, we readily acknowledge that our observed block of ketamine's antidepressant effect by naltrexone could be mediated by a direct action at an opioid receptor or via release of endogenous opioids.It is unknown what blood level of naltrexone is sufficient to block the effect of endogenous opioid release, but we would err toward higher blood levels when designing a study of antidepressant mechanism.We wholeheartedly agree that further clinical investigation of ketamine's interaction with the opioid system is needed, and our understanding of how, when, and in whom naltrexone affects mood is worth exploring further.
Systemic Inflammatory Response in Cardiac Allograft Vasculopathy
Authors: Klaus Pethig, Bernd Heublein, Ingo Kutschka, Axel Haverich
Journal: Circulation (2000)

Background —Response to immunologic and nonimmunologic injury has been reported to initiate the development of cardiac allograft vasculopathy (CAVD). Although histopathologic examinations reveal signs of focal inflammation, little is known about the systemic inflammatory response in this accelerated coronary syndrome. Methods and Results —Therefore, we investigated high-sensitive C-reactive protein (CRP) in a large cohort of heart transplant (HTX) recipients (n=102, 90 male, mean age 45.2±11.5 years, 6.1±3.3 years after HTX) in correlation with a progression of luminal obstruction as assessed by serial coronary angiography (defined as an increase of focal stenosis ≥30% or detection of a new lesion) after a mean interval of 1.8±1.0 years. Patients with signs of an acute rejection or infection were excluded. In the entire group, CRP levels ranged from 0.2 to 12.7 mg/L (mean 2.6±2.7 mg/L). Patients with progressive CAVD (n=35) presented with significantly higher levels of CRP (4.1±3.3 mg/L) than did those with a nonprogressive course (n=67) (1.8±1.9 mg/L, P =0.001). These observations were independent of the initial indication for HTX (atherosclerotic disorder versus cardiomyopathy, P =0.18) and the severity of CAVD at baseline examination ( P =0.12). Conclusions —Progressive cardiac allograft vasculopathy is accompanied by a systemic inflammatory reaction, which gives further insight into the pathogenesis of this coronary syndrome and may well serve as an indicator for patients at risk.
A Monograph on Gonorrhœa.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Population-based incidence of new ampicillin, cephalexin, cefaclor, and sulfonamide antibiotic "allergies” in exposed individuals with and without preexisting ampicillin, cephalexin, or cefaclor "allergies"
Authors: Eric Macy, Thomas McCormick, John Adams, William Crawford, Myngoc Nguyen, Anna Davis, Elizabeth McGlynn
Journal: Journal of Allergy and Clinical Immunology (2021)
Multifocal Autochthonous Transmission of Malaria—Florida, 2003
Journal: JAMA (2004)

The majority of malaria cases diagnosed in the United States are imported, usually by persons traveling from areas where malaria is endemic. However, small outbreaks of locally acquired mosquito-borne malaria continue to occur. During July-September 2003, an outbreak of malaria (eight cases of Plasmodium vivax malaria) occurred in Palm Beach County, Florida. During the same period, two patients were evaluated for malaria in neighboring Okeechobee County, approximately 75 miles from the Palm Beach County transmission area. One patient was thought to have acquired infection with the same parasite species (P. vivax), and concerns were raised about a possible link. To determine whether infection was acquired in Okeechobee County and whether a possible link existed to the Palm Beach County outbreak, the Florida Department of Health (FDOH) initiated an investigation. This report describes that investigation, which determined that although initial laboratory results suggested local transmission, subsequent evaluation and testing confirmed the case as imported malaria. These findings underscore the importance of a rapid and thorough investigation of any malaria case suspected to be acquired through local mosquito-borne transmission.
Die Aetiologie der bösartigen Geschwülste nach dem gegenwärtigen Stande der klinischen Erfahrung und der experimentellen Forschung.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toxemia, Placenta, and Immunity
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coffee.—
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal