tbuckley/cabot-search huggingface dataset:
Military Medical Manual
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Depth Electrode Studies of Thalamus and Basal Ganglia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of pharmacodynamic (PD) biomarkers in patients with metastatic pancreatic cancer treated with BL-8040, a novel CXCR4 antagonist.
Authors: Manuel M. Hidalgo, Ron Epelbaum, Valeriya Semenisty, Ravit Geva, Talia Golan, Erkut Hasan Borazanci, Salomon M. Stemmer, Mitesh J. Borad, Joon Oh Park, Katrina Pedersen, Brian M. Wolpin, Robert A. Ramirez, Carlos Becerra, Stephen Michael Shaw, Galia Oberkovitz, Ella Sorani, Tzipora M Lustig, Abi Vainstein Haras, Amnon Peled, Daniel D. Von Hoff
Journal: Journal of Clinical Oncology (2018)

276 Background: BL-8040 is a novel CXCR4 antagonist being developed for multiple oncology indications. Preclinical studies demonstrated that BL-8040 increases the number of immune cells in peripheral blood and promotes CD8+ T cell infiltration into orthotropic pancreatic mouse tumors, reducing tumor load. BL-8040 is being evaluated in a Phase 2a, multicenter, open label trial in patients with metastatic pancreatic cancer (the COMBAT study). Patients are undergoing a 5-day period of monotherapy in which they receive daily doses of BL-8040, followed by 21-day cycles in which patients receive one dose of pembrolizumab and 3 doses/week of BL-8040 until disease progression or discontinuation. To date, 32 patients have been enrolled. Methods: On Day 1 and Day 5, blood samples were taken at pre- and post-dosing, to evaluate peripheral immune cell subset frequency by flow cytometry. In addition, core biopsies were taken from liver metastases, where possible, to assess immune cell infiltration into tumors and the tumor microenvironment (TME). Results: Here we present interim PD biomarker data from the BL-8040 monotherapy portion of the trial. Flow cytometry shows that BL-8040 monotherapy caused an approximately two-fold reduction in frequency of peripheral T regulatory cells, but had no effect on the frequency of T cells, NKT cells or cell populations that contain B cells (CD3- CD56-). Additionally, BL-8040 remained bound to CXCR4 on peripheral immune cells throughout the period of monotherapy. Analysis of available biopsies (N = 7) shows an up to 15-fold increase in the CD3+ population, and up to two-fold increase of CD8+ cells, in the tumor periphery and TME of 43% (3/7) of the patients after five days of BL-8040 monotherapy compared to baseline. Conclusions: In summary, the PD biomarker results in humans support the proposed mechanism of action for BL-8040 that was based on preclinical mouse models. Analysis of tumor biopsies is ongoing, with an emphasis on investigating the effects of BL-8040 on tumor-resident immune cells and the TME. Clinical trial information: NCT02826486.
Wrong Issue
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LAW &amp;amp; MEDICINE
Authors: T.D. Johnson
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
US medical school finances
Authors: P. Jolly
Journal: JAMA (1987)

This review of the financial operations of US medical schools is intended to reflect trends in revenues and expenditures. The 28-year interval from 1958 to 1985 may be divided into two distinct periods, from 1958-1959 to 1978-1979 and from 1979-1980 to 1985-1986, the latest year for which financial data are available. The first period can be characterized by huge absolute and relative increases in all aspects of medical education. Some sense of the growth in the enterprise during the 21-year interval from 1958-1959 to 1978-1979 may be gleaned from an examination of a few of its dimensions shown in Table 1. The number of schools increased, the number of candidates for professional and academic doctorates doubled and tripled, respectively, and the population of postdoctoral students mushroomed. The seven-year period from 1979-1980 to 1985-1986, on the other hand, exhibits modest growth in the number of schools and the number of students,
<i>Exophiala</i> Infection From Contaminated Injectable Steroids Prepared by a Compounding Pharmacy—United States, July–November 2002
Journal: JAMA (2003)

In the United States, pharmacists compound medications to meet unique patient drug requirements or to prepare drug products that are not available commercially. In September 2002, the North Carolina Division of Public Health (NCDPH) was notified of two cases of meningitis caused by a rare fungus in patients who had received epidural injections at outpatient pain management clinics. This report describes five cases of fungal infection associated with contaminated drugs prepared at a compounding pharmacy. Clinicians should consider the possibility of improperly compounded medications as a source of infection in patients after epidural or intra-articular injections.
The Immunopathogenesis of Gastrointestinal and Hepatobiliary Diseases
Authors: Warren Strober
Journal: JAMA (1992)

THE MUCOSAL immune system is composed of afferent lymphoid tissues (the mucosal follicles, Peyer's patches) and efferent lymphoid tissues (the diffuse lymphoid tissues underlying the various epithelial surfaces of the gastrointestinal [GI], respiratory, and reproductive tracts and the lactating mammary gland), with several unique features that facilitate host defense at mucosal surfaces.<sup>1</sup>One unique feature is the tendency of cells originating in the mucosal follicles to migrate to the diffuse lymphoid areas; such mucosa-specific "homing" is a mechanism of targeting cells induced by mucosal antigens to mucosal areas. Another unique feature of the mucosal immune system is that B cells in mucosal follicles tend to differentiate into cells that produce polymeric IgA, an immunoglobulin particularly suited to mucosal function. This is seen in the ability of IgA to use the polymeric immunoglobulin transport receptor on the surface of mucosal epithelial cells (secretory component) to gain ready access to the
Dedication of the National Institute of Health
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Male Reproductive Toxicology: Comparison of the Human to Animal Models
Authors: Peter K. Working
Journal: Environmental Health Perspectives (1988)

The human male is of relatively low fertility and thus may be at greater risk from reproductive toxicants than are males of the common laboratory animal model species. Lack of knowledge of the physiological differences that contribute to interspecies variation between man and animals can prevent the effective application of animal data to the assessment of human reproductive risk. Evaluation of spermatogenesis from testicular histology, while uncommon, can provide valuable information about human reproductive risk. The measurement of sperm count or concentration has long been the most feasible approach for human semen evaluation, but may be an insensitive indicator of reproductive function because of high sample-to-sample variability. Interspecies extrapolation factors can be calculated by comparing the reduction in sperm count in humans and test species after exposure to drugs or chemicals. These factors can provide a realistic assessment of relative risk, provided that the sperm are counted at the appropriate time after exposure. However, the degree to which extrapolation factors derived for one agent, and only from sperm counts, can be generalized is not known. Monitoring of sperm motility and morphology parameters is also a common means of evaluating human semen quality, but these techniques are also hampered by the relatively high interindividual and intersample variability. Computer-assisted and morphometric approaches show promise of decreasing the subjective nature of these evaluations and increasing their value in risk assessment procedures. Improvements in predicting human reproductive risk can be expected to come from increased knowledge about reproductive mechanisms in man and animals, together with the utilization of objective measures of cellular indicators of male reproductive function.
Generally Speaking
Authors: Nicholas J. Pisacano
Journal: JAMA (1970)

I would like to set out with a few simple but sweeping<i>generalizations</i>concerning the impact of medical education on the practice of medicine. These<i>generalizations</i>are also,<i>in general</i>, negative. I make no apology for being negative nor do I subscribe to the sophistry of the academic world which implies that<i>generalizations</i>are necessarily false and lead to illogical conclusions. My first<i>generalization</i>, then, is (1) that medical schools have contributed little toward the improvement of the<i>practice</i>of medicine; (2) that, in fact, medical educators have very little understanding of what comprehensive medicine truly is; (3) that the rise of the newest approved specialty, family practice, after many abortive attempts at approval, owes little to medical educators for its eventual success in attaining approval on Feb 8, 1969; and (4) that, even in the light of this recent surge of interest in family practice, many deans and/or their
The Anatomy and Physiology of Primate Neurons that Control Rapid Eye Movements
Authors: A. Moschovakis
Journal: Annual Review of Neuroscience (1994)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Leads from the MMWR. Prevention and control of influenza
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HOOKWORM AND TUBERCULOSIS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum to: Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma
Authors: Ye Song, Qisheng Luo, Hao Long, Zheng Hu, Tianshi Que, Xi’an Zhang, Zhiyong Li, Gang Wang, Liu Yi, Zhen Liu, WeiYi Fang, Songtao Qi
Journal: Molecular Cancer (2014)
Hepatology Highlights
Authors: Jaspreet S. Suri, Ghideon Ezaz, Daryl T.Y. Lau, Tasha B. Kulai, Harmeet Malhi, Zaid H. Tafesh, Brett Fortune, Russell Rosenblatt, Robert S. Brown, Joseph F. Pisa, Nicholas Russo, Petra Hirsova, Robert E. Schwartz, Sayed Obaidullah Aseem, Nidhi Jalan‐Sakrikar, Vikas Gupta
Journal: Hepatology (2019)

Suri, Jaspreet S.; Ezaz, Ghideon; Lau, Daryl T.Y.; Kulai, Tasha B.; Malhi, Harmeet; Tafesh, Zaid H.; Fortune, Brett; Rosenblatt, Russell; Brown, Robert S. Jr.; Pisa, Joseph F.; Russo, Nicholas; Hirsova, Petra; Schwartz, Robert E.; Obaidullah Aseem, Sayed; Jalan‐Sakrikar, Nidhi; Gupta, Vikas Author Information
Steroids, diabetes, . . . and other stories
Journal: BMJ (2019)

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Outbreak of Aseptic Meningitis— Whiteside County, Illinois, 1995
Journal: JAMA (1997)

Aseptic meningitis (AM) is a severe, nonbacterial infection of the central nervous system that affects an estimated 30,000-50,000 persons each year in the United States. On July 21, 1995, the infection-control coordinator of the county hospital in Whiteside County (1990 population: 60,000), Illinois, reported to CDC an outbreak of AM. From June 7 through July 21, 1995, a total of 29 persons had onset of clinical AM, characterized by fever, headache, stiff neck, and photophobia. Many cases had cerebrospinal fluid (CSF) pleocytosis, and all had negative bacterial cultures. Preliminary identification of an enterovirus was made from virus-isolation studies. This report describes the investigation of this outbreak by county and state health officials, which indicated that, although members of the community were concerned about possible transmission at large public gatherings and several swimming locations, there was no risk for illness in these settings.
THE THERAPY OF THE COOK COUNTY HOSPITAL
Authors: BERNARD FANTUS
Journal: JAMA (1934)

<h3>THERAPY OF FRESH ACCIDENTAL WOUNDS</h3> The therapy of fresh accidental wounds must meet four general indications: check hemorrhage, treat shock, render the wound aseptic and put the affected part at rest, and restore the part to the greatest possible degree of usefulness. Hemorrhage may be checked by pressure (tourniquet, bandage), elevation or heat (120° F.). See also "Therapy of Bleeding." Shock may be treated by analgesia, recumbency and heat. See also "Circulation Deficiency Crises." The wound should be rendered aseptic and closed according to approved surgical principles as soon as this has probably been accomplished. An aseptic wound is one that heals by first intention without signs of excessive inflammation and without constitutional disturbance. It need not necessarily be sterile, i. e., completely free from micro-organisms. Asepsis is a clinical concept; sterility, a bacteriologic term. As an emergency dressing, the wound should be covered with the cleanest (most nearly sterile)
A community outbreak of Mycoplasma pneumonia
Authors: S. C. Copps
Journal: JAMA (1968)

An outbreak of nonbacterial pneumonia occurred in La Crosse, Wis, in the fall of 1965 and early 1966. Laboratory studies of 138 patients indicated infection with<i>Mycoplasma pneumoniae</i>in 66 patients (48%). Patients ranging in age from 5 to 19 years were most severely affected. Familial infection was common and the index case usually occurred in a teenager. The school was suspected as the source of dissemination but this could not be established from the data available. Cases were scattered throughout the city. Transmission seemed to require close and prolonged contact. Clinically, involvement was limited to the lower-respiratory tract with coughing and roentgenographic evidence of pneumonitis in almost all patients. In addition, seven patients had a rash and seven others had evidence of otitis media, one with bullous involvement.
SIR JOHN SIBBALD.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal