tbuckley/cabot-search huggingface dataset:
Family Doctor
Authors: Donna Doyle
Journal: JAMA (2012)

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Editorial Board
Authors: George Bartley, Henry Jampel, Daniel Albert, Andrew Schachat, Anita Agarwal, T Iqbal, Ike Ahmed, Jayakrishna Ambati, Tin Aung, James Brandt, Wiley Chambers, Emily Chew, Susan Day, San Francisco, Steven Gedde, Mingguang He, Ronald Klein
Journal: Ophthalmology (2013)
Do Women See Specialists for Routine Prenatal Care?
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JOHN BROWN (1810-1882)— EDINBURGH'S MEDICAL MAN OF LETTERS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment
Authors: Aurélie Caye, Kevin Rouault-Pierre, Marion Strullu, Elodie Lainey, Ander Abarrategi, Odile Fenneteau, Chloé Arfeuille, Jennifer Osman, Bruno Cassinat, Sabrina Pereira, Fernando Anjos-Afonso, Erin Currie, Linda Ariza-McNaughton, Vincent Barlogis, Jean-Hugues Dalle, André Baruchel, Christine Chomienne, Hélène Cavé, Dominique Bonnet
Journal: Leukemia (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Multiple false-positive serologic tests for HIV, HTLV-1, and hepatitis C following influenza vaccination, 1991
Authors: W. R. Mac Kenzie
Journal: JAMA (1992)

<h3>Objective.</h3> —(1) To assess factors associated with the occurrence of multiple false-positive viral enzyme-linked immunosorbent assays (ELISAs) for human immunodeficiency virus (HIV), human T-cell lymphotrophic virus type 1 (HTLV-1), and hepatitis C virus (HCV) among individual blood donors and (2) to determine the frequency and time course of this phenomenon. <h3>Design.</h3> —Case-control study. <h3>Setting.</h3> —A regional blood center. <h3>Participants.</h3> —Blood donors found to have multiple false-positive viral ELISAs (case donors) and randomly selected seronegative controls (control donors) who donated between October 31, 1991, and December 15, 1991. An additional random sample of 262 donation records was reviewed to calculate the proportion of donors who received influenza vaccine. <h3>Main Outcome Measures.</h3> —Multiple false-positive viral ELISAs, receipt of influenza vaccination formulated for the 1991-1992 influenza season, and follow-up ELISA results on serum samples obtained from case donors. <h3>Results.</h3> —Among 17 941 donors, 10 case donors were identified. Nine of the 10 case donors received influenza vaccine, compared with three of 30 control donors (odds ratio [OR]=81; 95% confidence interval [CI], 6 to 3670;<i>P</i>&lt;.001 ). Among nine case donors, the mean time between vaccination and blood donation was 26 days (range, 9 to 68 days). Follow-up ELISAs of serum samples from seven case donors obtained 52 to 130 days (mean, 75 days) after vaccination demonstrated reversion to HIV and HTLV-1 seronegativity in all but one specimen, with persistence of positive HCV ELISAs in four specimens. We estimate between 0.6% and 1.7% of blood donors who received influenza vaccine this season had multiple false-positive viral ELISAs. <h3>Conclusions.</h3> —The occurrence of multiple false-positive viral ELISAs among blood donors was associated with influenza vaccination, but was infrequent among vaccinees. This phenomenon is of short duration for HIV and HTLV-1, but may persist longer for HCV. We recommend influenza vaccinees not be deferred from blood donation. Blood donors with multiple false-positive viral ELISAs should be considered for future reentry as blood donors. (<i>JAMA</i>. 1992;268:1015-1017)
Bioaccumulation and Detection of Trace Levels of Cadmium in Aquatic Systems by Eichhornia crassipes
Authors: B. C. Wolverton, Rebecca C. McDonald
Journal: Environmental Health Perspectives (1978)

The water hyacinth (Eichhornia crassipes) may be used as a sensitive biological indicator for continuously monitoring trace quantities of toxic heavy metals in aquatic systems. A river water system polluted with cadmium was simulated while other factors of temperature, day-night cycle, water quality, and light intensity remained constant. When the water hyacinth is maintained in river water containing 0.001 mg/l. of cadmium chloride, the plant's root system will concentrate this element at an average rate of 0.9, 1.4, and 3.0 μg Cd/g root dry weight after 24, 48, and 72 hr exposure periods, respectively. At a higher cadmium concentration of 0.01 mg/l., cadmium was concentrated in the roots much faster to levels of 6.8, 13.6, and 39.1 μg/g root after 4, 8, and 24 hr exposure periods, respectively. At initial concentrations of 0.05 mg/l. cadmium, the roots contained 29.5, 48.8, and 156 μg/g root following 4, 8, and 24 hr exposure periods, respectively. During these same time intervals, the water hyacinth sorbed 56.7, 153, and 281 μg/g root when the initial cadmium concentration was increased to 0.10 mg/l. The water hyacinth tops can also assist in the monitoring process when cadmium contamination levels are 0.10 mg/l. and greater. At this initial cadmium concentration, cadmium is translocated into the tops. After 8 hr, the tops averaged 1.1 μg/g top. After 24 hr, this concentration was increased to 6.1 μg/g top.
Serious Adverse Events Attributed to Nevirapine Regimens for Postexposure Prophylaxis After HIV Exposures—Worldwide, 1997-2000
Journal: JAMA (2001)

In September 2000, two instances of life-threatening hepatotoxicity were reported in health-care workers taking nevirapine (NVP) for postexposure prophylaxis (PEP) after occupational human immunodeficiency virus (HIV) exposure. In one case, a 43-year-old female health-care worker required liver transplantation after developing fulminant hepatitis and end-stage hepatic failure while taking NVP, zidovudine, and lamivudine as PEP following a needlestick injury (1). In the second case, a 38-year-old male physician was hospitalized with life-threatening fulminant hepatitis while taking NVP, zidovudine, and lamivudine as PEP following a mucous membrane exposure. To characterize NVP-associated PEP toxicity, CDC and the Food and Drug Administration (FDA) reviewed MedWatch reports of serious adverse events in persons taking NVP for PEP received by FDA (Figure 1). This report summarizes the results of that analysis and indicates that healthy persons taking abbreviated 4-week NVP regimens for PEP are at risk for serious adverse events. Clinicians should use recommended PEP guidelines and dosing instructions to reduce the risk for serious adverse events.
Fibroblast RNA and Macrophage Proteins (Including the Fibrogenic Factor) in Experimental Silicosis
Authors: E. Kulonen, M. Aalto, S. Aho, P. Lehtinen, M. Potila
Journal: Environmental Health Perspectives (1983)

A hypothesis is presented for the action of silica-treated macrophages on protein synthesis in fibroblasts and also a method for the isolation of silica-attached materials in lung tissue. The increased protein synthesis in the fibroblasts is due, at least partly, to an increase in mRNA. Silica prevents the suppressing "macrophage effect" of macrophage-originated ribonuclease on fibroblasts. However, under certain conditions, collagen synthesis is stimulated by silica-treated macrophage preparations to such an extent that the effect cannot be explained by the inhibition of macrophage ribonuclease alone. We therefore postulate the existence of a fibrogenic factor, which is released by the macrophages. This factor has been demonstrated and can be purified from lung homogenate of SiO2-treated rats.
Erratum: Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions
Authors: Kiki Tesselaar, Ramon Arens, Gijs M.W. van Schijndel, Paul A. Baars, Martin A. van der Valk, Jannie Borst, Marinus H.J. van Oers, René A.W. van Lier
Journal: Nature Immunology (2003)
Prediction of the Carcinogenicity of a Second Group of Organic Chemicals Undergoing Carcinogenicity Testing
Authors: Y. P. Zhang, N. Sussman, O. T. Macina, H. S. Rosenkranz, G. Klopman
Journal: Environmental Health Perspectives (1996)

Twenty-four organic compounds currently undergoing testing within cancer bioassays under the aegis of the U.S. National Toxicology Program (NTP) were submitted to the computer automated structure evaluation (CASE) and multiple computer automated structure evaluation (MULTICASE) system for predictions of activity.Individual predictions resulting from the NTP combined rodent, NTP mouse, Carcinogenic Potency Database (CPDB) combined rodent, and CPDB mouse data- bases were combined using Bayes' theorem to yield an overall probability of rodent carcinogenicity.Based upon an arbitrary probability cut-off of 0.50, nine compounds were predicted to be rodent carcinogens.The predicted carcinogens are chloroprene, 1-chloro-2-propanol, codeine, emodin, furfuryl alcohol, isobutyraldehyde, primaclone, sodium xylenesulfonate, and t-butylhydroquinone.
Erratum
Authors: None &NA;
Journal: Clinical Nuclear Medicine (1977)

Cancer of the prostate is the most common neoplasm in man metastatic to bone. Early detection of skeletal involvement is important in staging and selection of therapy. This study was undertaken to determine the accuracy of nonoperative techniques for detecting bony metastases from carcinoma of the prostate. One hundred ten unselected patients with biopsy-proven carcinoma were examined by 99mTc-pyrophosphate bone scan and radiographic bone survey. Bone scans and radiographic surveys were obtained within one month of the initial diagnosis and prior to the introduction of therapy. Heat-labile serum alkaline phosphatases and prostatic fractionated serum acid phosphatases were obtained at the time of bone scan. Results show that 37 of 110 patients had evidence of bony metastases on bone scan. In 25 of these patients, there were abnormal radiographic surveys. Twenty of these patients had abnormal alkaline phosphatases and 18 patients had abnormal acid phosphatases. In 77 patients with normal bone scans, 18 had elevated alkaline phosphatases and 12 had elevated acid phosphatases. These findings suggest that bone scanning is of considerable importance in the management of newly-diagnosed carcinoma of the prostate. As a screening procedure, bone scanning is superior to radiographic bone survey. Surprisingly, elevated serum acid phosphatase was not as useful as bone scanning in the diagnosis of bony metastases from carcinoma of the prostate.
Study of Human Lactation for Effects of Environmental Contaminants: The North Carolina Breast Milk and Formula Project and Some Other Ideas
Authors: Walter J. Rogan, Beth C. Gladen
Journal: Environmental Health Perspectives (1985)

The presence of environmental contaminant chemicals in human milk, their demonstrated toxicity, and the lack of data in human beings led to the North Carolina Breast Milk and Formula project, a three-center prospective birth cohort study of 856 children. In this study, we measure polychlorinated biphenyls (PCBs) and DDE in milk and other fluids, follow the course of lactation, and note growth, morbidity and development in the children. Lactation is hormonally complicated and has parts that are plausibly interfered with by contaminant chemicals, and certain kinds of morbidity that occur in breastfed children might also represent the result of chemical contamination of milk. Preliminary data analysis confirms the widespread presence of chemicals in milk; women with higher DDE levels do not breast-feed as long, but this is not true for women with higher PCBs. Besides this study, several case-control or survey-type studies, such as studies of failure to thrive, certain rashes, or short-term breast-feeding would be helpful. Laboratory studies of enzyme induction are now feasible in children and might be a very sensitive if not totally specific endpoint for study of PCBs in milk.
Essai randomisé capsule colique versus coloscanner chez les patients avec test au Gaiac positifs, refusant la coloscopie
Journal: Endoscopy (2018)

Introduction: En France, environ 10 % des patients ayant un test de dépistage du cancer colorectal au Gaïac positif ne réalisaient pas de coloscopie dans les suites comme recommandé. L’objectif de cette étude menée dans 2 départements français (Loire et Rhône) était de comparer la vidéocapsule endoscopique (VCE) au coloscanner (CS) en termes de taux de participation et taux de détection chez ces patients.
Medical News and Perspectives
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anti-HBS induction and HBsAg reduction by nasal administration of a therapeutic vaccine containing HBsAg and HBcAg (NASVAC) in patients with chronic HBV infection
Authors: Osamu Yoshida, Akbar Sheikh Mohammad Fazle, Takahiro Sanada, Michinori Kohara, Kyoko Tsukiyama-Kohara, Takashi Miyazaki, Taizo Kamishita, Mamun Al-Mahtab, Aguilar Julio, Gerardo Guillen, Yoichi Hiasa
Journal: Journal of Hepatology (2020)
Diagnostic and therapeutic technology assessment. Chorionic villus sampling: a reassessment
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Problem doctors
Authors: J D Middleton
Journal: BMJ (1994)

appreciable number of senior house officers enter general practice and therefore there will be many departments with a two day shortfall in senior house officers.The NHS executive must be reminded that senior house officers do not rotate endlessly within the NHS hospitals, but follow a career path.Any plans for changing the start dates of house officers must take into account the end points of these career paths, which may lie outside NHS hospitals.
Abstract 433: HDAC7 is Essential for Stem Cell Differentiation into Smooth Muscle Cells
Authors: Andriana Margariti, Qingzhong Xiao, Anna Zampetaki, Yanhua Hu, Lingfang Zeng, Qingbo Xu
Journal: Circulation (2007)

Background: Embryonic stem cells (ESCs) possess the potential to differentiate into specific cell lineages, such as vascular smooth muscle cells (SMCs). The homeostasis of histone acetylation and deacetylation mediated by histone deacetylase (HDAC) is known to play a central role in the regulation of gene expression, through co-operation with other transcription factors. However, it is unknown whether HDAC plays a role in mediating stem cell differentiation into SMCs. Methods and results: Mouse ESCs were seeded on collagen IV-coated flasks and cultured in the absence of Leukemia Inhibitory Factor (LIF) in differentiation medium for 3 to 9 days in order to induce SMCs differentiation. Western blots and double-immunofluorescence staining demonstrated that HDAC7 expressed in parallel with SMC marker genes. Upregulation of HDAC7 expression resulted in increase in SMC marker expression, while downregulation of HDAC7 by siRNA caused decrease of SMC marker expression. In ex vivo culture of embryonic cells from SM22-LacZ transgenic mice, over-expression of HDAC7 significantly increased beta-gal positive cells, indicating a crucial role of HDAC7 in SMC differentiation during embryonic development. An important observation of this study is that HDAC7 undergoes alternative splicing during ESC differentiation, resulting in alternative translation from second ATG codon, giving rise to a short HDAC7 missing the N-terminal 22 amino acids. We also found that PDGF induced SMCs differentiation through the regulation of HDAC7 transcription and splicing, in which siHDAC7 knockdown ablated PDGF-induced SMC marker expression. Spliced HDAC7 increased SMC differentiation, while the short HDAC7 had no effect or even downregulated SMC differentiation. Further experiments revealed that the short HDAC7 isoform bound to MEF2C, while the full length HDAC7 did not, indicating that HDAC7 splicing can induce SMCs differentiation through the modulation of MEF2C-mediated gene expression. Conclusions: Our findings provide novel information on the mechanism involved in SMC differentiation, and identify HDAC7 as a new target in therapeutic intervention on vascular disease, where inhibition of vascular progenitor cell differentiation into SMCs would be beneficial.
PROCEEDINGS OF THE SECOND MEETING OF THE CENTRAL SOCIETY FOR CLINICAL RESEARCH HELD IN CHICAGO, NOVEMBER 22, 1929
Journal: Journal of Clinical Investigation (1930)

An organic substance obtained from the suprarenal.cortex,when fed to two patients with primary anemia during relapse, in amounts of 33 mgm.three times daily, produced reticulocyte responses similar to those obtained with the feeding of liver, kidney, stomach or fractions of liver.Following the reticulocyte re- sporise, the red blood cells increased in number approximately equal to the number of young cells appearing in the blood on the day of the peak.There was little, if any, clinical improvement in the patients, and the continued feeding of the preparation did not produce a further increase in the total number of red blood cells.Subsequently, these patients were given adequate daily amounts of liver extract no.343, and in each instance the clinical improvement was marked and the level of the red blood cells reached normal.This suggests the possibility that the mechanism of producing a remission of the red blood cells in primary anemia is not entirely dependent upon the initial delivery of reticulocytes into the circulation, but is probably associated with a growth-promoting substance not present in the organic material obtained from the suprarenal cortex, but present in liver, kidney, and potent fractions of liver.