tbuckley/cabot-search huggingface dataset:
Abstract 5447: Thromboxane A <sub>2</sub> Receptor Activation Attenuates Insulin Signaling and Angiogenesis by Upregulating Phosphatase PTEN in Cultured Endothelial Cells
Authors: Ping Song, Shuangxi Wang, Maio Zhang, Jian Xu, Yong Wu, Ming-Hui Zou
Journal: Circulation (2008)

Increasing evidence indicates that elevated levels of endogenous thromboxane receptor (TPr) agonists including thromboxane (Tx) A 2 , prostaglandin H 2 , and 8-iso-prostaglandin F 2a contribute to insulin resistance, endothelial dysfunction, and accelerated atherosclerosis in diabetes. However, the mechanisms by which TPr triggers insulin resistance in endothelial cells remaine poorly defined. Here we show how TPr activation impairs insulin signaling and angiogenesis in endothelial cells. Exposure of cultured human umbilical vein endothelial cells (HUVEC) to a structurally related TxA 2 mimetic (IBOP, U46619, or carboxy-TxA 2 ) for 3 or 16h significantly inhibited both basal- and insulin-stimulated Akt-Ser473 phosphorylation, Akt activity, the serine 1177 phosphorylation of endothelial nitric oxide synthase (eNOS-Ser1177), and angiogenesis. Concomitantly, IBOP significantly increased the levels of Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) and PTEN phosphorylation at Ser380/Thr382/383. Further, Y27632, a Rho kinase (ROCK) inhibitor, abolished the effects of IBOP on the phosphorylation of PTEN, Akt and eNOS, and the PTEN level. Similarly, inhibition of PTEN by small interference RNA (siRNA), like the selective TPr antagonist, SQ29548, or knockdown of TPr by siRNA, abolished IBOP-induced inhibition on both the phosphorylation of the Akt-eNOS axis and angiogenesis. Furthermore, IBOP significantly increased the Ser428 phosphorylation of LKB1, a known upstream kinase for PTEN. Finally, suppression of LKB1 abolished IBOP-induced PTEN phosphorylation and PTEN accumulation in HUVEC. We conclude that TPr suppresses insulin signaling and angiogenesis by upregulating RhoA mediated but LKB1-dependent PTEN phosphorylation in endothelial cells. This research has received full or partial funding support from the American Heart Association, AHA South Central Affiliate (Arkansas, New Mexico, Oklahoma &amp; Texas).
Stress and somatic disease
Authors: W. F. Kiely
Journal: JAMA (1973)

Psychosocial factors play an important though variable role in the predisposition, precipitation, and clinical course of most human illness. In a particular group of somatic diseases of uncertain cause—perhaps most appropriately classed as somatopsychic—the influence of psychosocial factors would appear to be greater than it is in diseases of simpler origin. Measles and essential hypertension, for example, could be one example of such a distinction. Central to the distinction is the degree to which the brain appraises or evaluates the situation, selects, and directs the response from the repertoire of the person challenged. Thus, whereas viral invasion may evoke little brain-directed response, situational or environmental strain may pose a challenge. Threat, whether or not perceived consciously, calls forth, largely at the subcortical level, certain biological response patterns whose original adaptive purpose was to cope with the potential injury and to master the challenge. Such systems are already developed and operative
Radiation Therapy for Cancer of the Nasopharynx
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCE Treatment Pasta-Bilities
Authors: W. Conard Holton
Journal: Environmental Health Perspectives (1999)

Monsanto's "Lasagna" process uses layers of treatment zones spaced between buried electrodes to remove trichloroethylene (TCE) from contaminated soil and groundwater. TCE is used primarily as a metal degreaser as well as in products such as dyes, printing ink, and paint. TCE can eventually make its way into the environment and is prevalent in the water and soil of industrialized nations. Although TCE breaks down in a few days when released into the atmosphere, it degrades much more slowly in soil, taking months or years. Moreover, it is often broken down by microbes into toxic substances such as vinylidene chloride (a suspected human carcinogen) and vinyl chloride (a known human carcinogen). The Lasagna process is based on the principle of electro-osmosis, in which an electric current draws water from low--permeability soils such as clays, silts, and fine sands. To remove TCE from contaminated soils, Monsanto scientists added layers of filtering media, which attack the contaminant as it is pulled from electrode to electrode. The technology has been tested at the Paducah Gaseous Diffusion Plant in western Kentucky, where it removed over 98% of TCE from contaminated soil.
Physical measures for the prevention and treatment of deformities following burns
Authors: G. H. Koepke
Journal: JAMA (1967)

Deeply burned tissues undergo inflammatory changes that often lead to contractures and ultimate deformity. Less deformity will occur if the burned segments of the body are placed in a functional position and if passive exercises are given during the periods of debridement and initial grafting. Reconstructive procedures should be followed immediately by the judicious use of splints that will maintain the corrected position and reduce the need for repeated operations.
National trends in admissions for potentially preventable conditions among patients with metastatic solid tumors, 2004-2014.
Authors: Robert Michael Daly, Marwan S. Abougergi
Journal: Journal of Clinical Oncology (2018)

e18813 Background: The Centers for Medicare and Medicaid Services (CMS) has identified 10 conditions for hospitalization among patients receiving chemotherapy that are potentially preventable through appropriately managed outpatient care. CMS plans to measure hospitals’ performance based on frequency of admission for: anemia, dehydration, diarrhea, emesis, nausea, neutropenia, fever, pain, pneumonia, and sepsis. Our objective was to measure hospital utilization patterns for these conditions. Methods: Nationally representative data from the 2004 and 2014 National Inpatient Sample were analyzed. Adults with stage IV solid tumors admitted with a principal diagnosis of one of the ten conditions were identified using ICD-9 codes provided by CMS. The primary outcome was number of admissions. Secondary outcomes were total hospitalization costs, length of stay (LOS), and in-hospital mortality rate. Proportions and count data were compared using chi-square and binomial test, respectively. Results: Between 2004 and 2014, potentially preventable hospitalizations increased from 64,053 to 85,740 (p < 0.01). The most frequent reason for admission was pneumonia (32%) in 2004 and sepsis (41%) in 2014. Table 1 provides the results for the year 2014 by condition. Hospitalizations for sepsis had the longest mean LOS (p < 0.01), highest mean total costs (p < 0.01) and most frequently resulted in death (p < 0.01). Conclusions: The Department of Health and Human Services states, “Improving patients’ quality of life by keeping patients out of the hospital is a main goal of cancer care.” Despite supportive care advances, the increased frequency of hospitalization demonstrates a need for continued symptom management innovation. Infectious symptoms should be a focus of these technologies given their high prevalence, mortality and resource utilization. Condition Admissions (n) Mean LOS Mean total cost Discharge = death Anemia 8,050 4.6 $9866 5% Dehydration 6,355 4.4 $7,572 5% Diarrhea 1,115 5.4 $9,010 2% Emesis 1,795 4.3 $8,952 7% Fever 2,070 3.1 $6,787 0.2% Nausea 2,780 4.1 $6,821 2% Neutropenia 5,970 5.1 $10,367 3% Pain 3,200 3.1 $7,143 2% Pneumonia 19,065 5.9 $11,919 10% Sepsis 35,340 7.0 $17,760 27%
From the NIH: Transfusions improve outcomes of pregnancies complicated by sickle cell disease
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notch activates cell cycle reentry and progression in quiescent cardiomyocytes
Authors: Víctor M. Campa, Raquel Gutiérrez-Lanza, Fabio Cerignoli, Ramón Díaz-Trelles, Brandon Nelson, Toshiya Tsuji, Maria Barcova, Wei Jiang, Mark Mercola
Journal: The Journal of Experimental Medicine (2008)
Details of circulatory system, chest yielding to computed tomography
Authors: C. Rinke
Journal: JAMA (1981)

Computed tomography (CT) still reigns as the hottest technology in medicine, revolutionizing the diagnostic capabilities of most medical specialties. A number of studies are in progress to further delineate its specific diagnostic potential. At the American College of Chest Physicians meeting in Boston, one panel focused on the use of CT to diagnose heart and lung disease. The CT whole-body scanner, which is used to visualize the thorax, revolves a roentgenographic beam around a patient, completing a 360-degree revolution in about 4 1/2 s. A 1-cm tissue plane is scanned and then converted into an image that is first depicted by a set of attenuation numbers. These numbers represent the rate at which the beam penetrates the tissues of the thorax, thus reflecting tissue density. Bone has arbitrarily been assigned an attenuation number of +1,000, air —1,000, and water 0. Hence the first image is a set of numbers indicating
Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro
Authors: K Matsumoto
Journal: Hepatology (1994)

Recombinant growth factors and proinflammatory cytokines were added to primary cultures of human intrahepatic biliary duct epithelia to test for their ability to stimulate DNA synthesis and elicit cytokine production. Interleukin-6 and hepatocyte and epidermal growth factors were found to increase the DNA labeling index of biliary duct epithelium from fourfold to sixfold 24 hr after their addition to primary biliary duct epithelium cultures maintained in serum-free medium. The proliferative responses to all three biliary duct epithelium mitogens peaked within 24 hr, and hepatocyte growth factor was effective over a concentration range of 1.0 to 50 ng/ml, whereas interleukin-6 was effective from 1 to 1,000 U/ml. Insulin-like growth factor, phorbol myristate acetate, interleukin-1β and platelet-derived growth factor BB showed mild stimulatory effects, whereas interleukin-4, γ-interferon, phytohemagglutinin and platelet-derived growth factors AA and AB did not increase DNA synthesis in biliary duct epithelium. Interleukin-1β and phorbol myristate acetate were also shown to induce in a dose-dependent fashion a threefold to fivefold increase of interleukin-6 production as measured by enzyme-linked immunosorbent assay in human primary biliary duct epithelium cultures, when compared with hepatocyte growth factor, epidermal growth factor, insulin-like growth factor, phytohemagglutinin, tumor necrosis factor-α or platelet-derived growth factor. These results show that interleukin-6 participates in growth regulation of human biliary duct epithelium. This could be exerted in a paracrine or autocrine manner. The ability of an inflammatory cytokine to directly promote biliary duct epithelium DNA synthesis provides a link between liver inflammation (or the immune system) and the repair response (growth and development), both of which are important in the histopathology of liver disease. (Hepatology 1994;20:376–382.)
PETROLATUM IN ANTERIOR CHAMBER FOLLOWING CATARACT EXTRACTION
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Adolescent Exceptional Child, a Realistic Approach to Treatment and Training:
Journal: Annals of Internal Medicine (1955)

This 78-page pamphlet constitutes the proceedings at the third Conference on the Exceptional Child to be held under the auspices of The Woods Schools for Exceptional Chil- dren.The other two conferences took place in 1950 and 1953 and dealt with the Exceptional Child in Infancy and Early Childhood, and the Exceptional Child in the Pre- adolescent Years,, respectively.All conference proceedings, including this pamphlet, are available free of charge upon request to The Woods Schools at Langhorne, Pennsylvania.This, the most recent of these conferences, deals with the diagnosis, treatment, training and, particularly, the occu- pational placement of the retarded adolescent.The discus- sion by the representative panel will be of interest to edu- cators, physicians, parents, and all others concerned with the handling and guidance of retarded children.
The Alleged Cure for Lockjaw.
Authors: S. A. Matthews
Journal: JAMA (1903)

Chicago, Aug. 25, 1903. <h3>To the Editor:</h3> —Certain publicity given by the lay press to a case of tetanus recently treated by me, and an editorial inThe Journallast week, make the following statement necessary: In the first place, I disclaim any pretention to the discovery of a specific cure for tetanus or for any other disease. However, during the past year I have made a study of the diuretic effects of certain salt solutions when injected directly into the circulation in mammals (rabbits), and the power of such diuretic saline solutions to eliminate soluble toxins from the body. To prove the theory I chose tetanus toxin, which I found could be eliminated from the body, at least in part, after sufficient time had elapsed for it to set up its characteristic symptoms. I tested this on a number of animals (each animal being controlled) with a large per
What benefits will self-employed doctors receive under social security?
Authors: R. J. Myers
Journal: JAMA (1966)

After many years of debate, a bill has been passed extending compulsory coverage under old-age, survivors, and disability insurance (OASDI), as well as a new program of hospital insurance (HI), to self-employed physicians. It is not the purpose of this report to argue the merits of such compulsory coverage. Rather, it is to point out the effects of coverage and the protection that is provided, and particularly to illustrate the benefits that accrue to the older doctors brought under the program. These advantages derive from liberalizations contained in the 1960 and 1961 amendments to the Social Security Act, as well as in the current amendments. This presentation is concerned only with male self-employed physicians and does not encompass the effect of any coverage secured through work as an employee. It is also assumed that annual earnings are at least equal to the maximum taxable earnings, $6,600 beginning in 1966 ($4,800
Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bernardo Study
Authors: E. Barrett-Connor
Journal: JAMA (1994)

<h3>Objective.</h3> —To describe the association of lifetime intake of caffeinated coffee, in cup-years, to bone mineral density (BMD) of the hip and spine in postmenopausal women; and to determine the effect of regular milk intake on this association. <h3>Design.</h3> —Women from an established epidemiologic cohort had measures of BMD and gave a medical and behavioral history that included caffeinated coffee and daily milk intake between the ages of 12 and 18 years, 20 and 50 years, and 50 years of age and older. <h3>Setting.</h3> —A community-based population of older women, Rancho Bernardo, Calif. <h3>Participants.</h3> —All 980 postmenopausal women aged 50 to 98 years (mean age, 72.7 years) who participated between 1988 and 1991. <h3>Main Outcome Measures.</h3> —Bone density at the hip and lumbar spine measured by dual energy x-ray absorptiometry. <h3>Main Results.</h3> —There was a statistically significant graded association between increasing lifetime intake of caffeinated coffee and decreasing BMD at both the hip and spine, independent of age, obesity, parity, years since menopause, and the use of tobacco, alcohol, estrogen, thiazides, and calcium supplements. Bone density did not vary by lifetime coffee intake in women who reported drinking at least one glass of milk per day during most of their adult lives. <h3>Conclusions.</h3> —Lifetime caffeinated coffee intake equivalent to two cups per day is associated with decreased bone density in older women who do not drink milk on a daily basis. (<i>JAMA</i>. 1994;271:280-283)
New Educational Institution—The European School of Oncology
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article New Educational Institution—The European School of Oncology Get access JNCI: Journal of the National Cancer Institute, Volume 70, Issue 5, May 1983, Page 987, https://doi.org/10.1093/jnci/70.5.987-a Published: 01 May 1983
<i>Circulation: Cardiovascular Genetics</i> ' Editors' Picks
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series summarizes the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the Editors' Picks for each Circulation: Cardiovascular Genetics' issue published in 2011.
Virologic Outcomes of Complex Drug Regimens for Human Immunodeficiency Virus—Reply
Authors: Scott M. Hammer, Florin Vaida, Kara K. Bennett, John W. Mellors
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Current Comment
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Embolism
Authors: Sharon Parmet
Journal: JAMA (2006)

Pulmonary EmbolismA pulmonary embolism is a blood clot that travels to the lungs.Often, the clot forms in another part of the body, usually in the veins of the legs.Large clots can be fatal.The January 11, 2006, issue of JAMA includes an article about diagnosing pulmonary embolism.This Patient Page is based on one previously published in the December 3, 2003, issue of JAMA.