tbuckley/cabot-search huggingface dataset:
MEDICAL CONFIDENCES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anoxia Neonatorum
Authors: Charles Leavitt Sullivan
Journal: New England Journal of Medicine (1946)

OLIVER Wendell Holmes, ecturing in anatomy to the students at Harvard Medical School, held aloft the skeleton of a female pelvis and delineating the pubic arch, said, "This, gentlemen, is the triumphant arch, beneath which all heroes must pass as the first hazard to be overcome along the path to their ultimate coronation." Dr. Holmes apparently gave little consideration to birth by cesarean section, but today it is known that that particular method of entrance into this world is not without its inherent perils to incipient heroes. I doubt whether Holmes was cognizant of the problems of anoxia, but then, . . .
BROMIDE INTOXICATION
Authors: J. C. SHARPE
Journal: JAMA (1934)

As a clinical entity, bromide intoxication has been recognized for some time by the psychiatrists. However, it is not infrequently observed in a general medical service and may give rise to some very puzzling diagnostic problems. Bromides were discovered by Balard in 1826 and introduced later into therapy by Graf in 1840.<sup>1</sup>The first case of bromide intoxication was reported by Huette<sup>2</sup>in 1850. In 1901, Landenheimer<sup>3</sup>was the first to recognize the important influence of the intake of chlorides on the retention of bromides. More recently Wuth,<sup>4</sup>in a six months period at the Henry Phipps Psychiatric Clinic of the Johns Hopkins Hospital, reported twenty cases of bromide intoxication that occurred among 238 admissions. Wagner and Bunburg<sup>5</sup>stated that in 1,000 consecutive patients admitted to the Colorado Psychopathic Hospital, forty-four showed the presence of bromides in the blood, and in seventeen of these the
Correction to: 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Journal: Circulation (2019)

several corrections were needed.1. On page e637, in the "Writing Committee Members" section, "FACC" is added to the credentials for Dr. Van Hare. 2. On page e650, in "Table 6. Delivery of Care: Circumstances Where ACHD Expertise May Improve Outcomes," second row "Patients with ACHD and pulmonary hypertension," last column "Example," in the second sentence, the measurement for Wood units read "Wood units/m 2 ."It is updated to read, "Wood units x m 2 ."3. On page e668, in "Figure 4. Pulmonary valve replacement in patients with TOF repair and PR," sixth row, in the large white diamond, a dagger symbol was added to the text.It now reads, "Any 2 of the following †:…" 4. On page e668, in the legend to "Figure 4. Pulmonary valve replacement in patients with TOF repair and PR," the following sentence was added: " †See recommendation 6 supporting text in the full text of the "2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease."P-9 5. On page e673, in the "4.4.4.1.Severe PAH" section, the recommendation table, in Recommendation 1, the measurement for Wood units read "Wood units/m 2 ."It is updated to read, "Wood units x m 2 ."6.On page e693, in "Appendix 1. Author Relationships With Industry and Other Entities (Relevant)-2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease* (February 2018)," in the entries for Dr. Aboulhosn and Dr. Khairy, the last column "Recusals by Section," one of the sections listed read, "4.3.1.2."It is updated to read, "4.3.2." 7.
Abstract 506: A homogenous PBMC ADCC bioassay enables bridging studies with ADCC reporter bioassays in immunotherapy monoclonal antibody development
Authors: Pete Stecha, Denise Garvin, Julia Gilden, Jun Wang, Jamison Grailer, Jim Hartnett, Gopal B. Krishnan, Frank Fan, Mei Cong, Zhijie Jey Cheng
Journal: Cancer Research (2021)

Abstract Measurement of antibody-dependent cellular cytotoxicity (ADCC) is critical for understanding antibody Fc effector functions during monoclonal antibody development. Classic ADCC assays measure the short-term cytotoxicity of target cells, typically pre-loaded with radioactive or fluorescent dyes, after exposure to antibody bound primary PBMCs or NK cells. These assays are widely used in antibody discovery and characterization during early drug development. However, the reproducibility of these assays is not adequate and they have major issues on biosafety or weak assay sensitivity. Moreover, the use of primary effector cells makes them prone to donor variability, low-throughput and therefore not suitable for implementation in quality-control drug development. We previously developed an ADCC reporter bioassay using engineered ADCC effector cells and demonstrated its specificity and ability to measure ADCC mechanism of action. The assay is prequalified according to ICH guidelines; demonstrates precision, accuracy, linearity, and robustness; and is suitable for product release and stability studies in a quality-controlled environment. In order to enable bridging studies comparing primary PBMC-based ADCC assays and ADCC reporter bioassays, we report the development of an improved PBMC ADCC assay using ADCC-prequalified PBMCs and engineered HiBiT target cells for therapeutic monoclonal antibodies with Fc functions. When target cells expressing HaloTag-HiBiT are incubated with an antibody and PBMCs, the target cells are lysed and release HaloTag-HiBiT, which then bind to LgBiT in the detection reagent to form a functional Nano-luciferase to generate Bioluminescence signal. In addition, it can enable the quantitative measurement of antibody-mediated target cell lysis via specific HaloTag staining using a fluorescent HaloTag ligand by flow cytometry. We demonstrate that the new PBMC ADCC assay is simple, homogenous, highly sensitive, and gives a robust assay window, and is capable of measuring potency of rituximab, cetuximab or trastuzumab. Additionally, it shows antibody potency comparable with the ADCC reporter bioassay in ADCC bridging studies. Citation Format: Pete Stecha, Denise Garvin, Julia Gilden, Jun Wang, Jamison Grailer, Jim Hartnett, Gopal B. Krishnan, Frank Fan, Mei Cong, Zhijie Jey Cheng. A homogenous PBMC ADCC bioassay enables bridging studies with ADCC reporter bioassays in immunotherapy monoclonal antibody development [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 506.
<i>A Pocket Medical Dictionary,</i>giving the pronunciation and definition of the principal words used in medicine and the collateral sciences, including very complete tables of clinical eponymic terms of the arteries, muscles, nerves, bacteria, bacilli, micrococci, spirilla and thermometric scales, and a dose-list of drugs and their preparations in both the English and metric systems of weights and measures. By George M. Gould, M. D. Fourth edition, revised and enlarged. 30,000 words. (…
Journal: American Journal of Psychiatry (1901)
Hasidism
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunoaugmentative Therapy
Authors: Sau Green
Journal: JAMA (1993)

THE BELIEF that the clinically normal human immune system maintains a continuous surveillance for cancer cells and can evoke an immunologic intervention to destroy them is so appealing and full of emotionally charged wishful thinking that it has become dogma in the lay literature. Because cancer is so prevalent, but so rarely detected in its earliest stages, it is easy for the entrepreneurs who sell unproven cancer treatments to explain that damage to the immune system caused the loss of its anticancer "surveillance" function and allowed the cancer to survive and flourish. They then claim that the "nontoxic" treatments they sell will "repair, replace, rejuvenate, or reactivate" the damaged immune system and allow the patient's own body to "cure itself of the cancer." Immunoaugmentative therapy (IAT), a treatment for cancer invented by zoologist Lawrence Burton, PhD, is based on these assertions.<sup>1</sup> Recently, the Office of Technology Assessment of the
Entre cirujanos y hospitales
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General Medicine.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Phreno-oesophageal Ligament in Hiatal Hernia Repair
Journal: Thorax (1961)

OESOPHAGUSand all of this tube is regarded as oesophagus, irrespective of its lining.The lower centimetre or two of this tube is normally lined by columnar epithelium, previously called cardiac and regarded as gastric, but in this paper called junctional and regarded as oeso- phageal.Thus the view that the oesophagus is a tube lined only by squamous epithelium is rejected.The cardia is defined as the lower sphincteric part of the oesophagus between the attachment of the phreno-oesophageal ligament and the oeso- phago-gastric junction.Some changes in opinions about lesions involving the lower end of the oesophagus, which must follow if these new views on its anatomy are accepted, are indicated.In particular it is pointed out that all the literature about gastric epithelium in the oesophagus in cases of reflux oesophagitis becomes invalid because with the new outlook it is simply oesophageal epithelium in the oesophagus.It is probably neither ectopic, nor congenital, nor permanent, nor in need of resection but metaplastic and reversible.I should like to thank Mr. N. R.
Homicides Among 15-19-Year-Old Males— United States, 1963-1991
Journal: JAMA (1994)

In 1991, nearly half (13,122 [49%]) of the 26,513 homicide victims in the United States were males aged 15-34 years. In addition, among males in this age group, homicide accounted for 18% of all deaths and was the second leading cause of death (Table 1). During 1963-1991, the pattern of homicide rates changed substantially; the change was greatest for males aged 15-19 years, for whom rates increased substantially (Figure 1). This report summarizes these trends and presents strategies for violence prevention and intervention.
From the Centers for Disease Control. Quarterly acquired immunodeficiency syndrome map
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Knowing When Surgery Will Help
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac effects of lightning stroke
Authors: J. P. Kleiner
Journal: JAMA (1978)

APPROXIMATELY 150 people are killed by lightning annually in the United States, and an estimated twice that number are injured.<sup>1,2</sup>Death in most is due to either respiratory arrest or cardiac arrhythmias. Although minor ECG changes are frequent in survivors of lightning injury, clinical evidence of actual myocardial damage is uncommon. We report the case of a young man struck by lightning who was initially asymptomatic and appeared to have suffered only mild superficial burns. An ECG, however, suggested acute myocardial injury, and three hours later acute pulmonary edema developed. Subsequent hemodynamic investigations confirmed the presence of myocardial damage. <h3>Report of a Case</h3> During field training maneuvers, three young soldiers were asleep in their tent when struck by lightning. All were stunned and suffered minor first- and second-degree burns to the neck, chest, and back, but none lost consciousness. When seen in the emergency room, all were alert, well
Jacob Mackinnon
Journal: BMJ (2006)

British family planning doctor whose assisted suicide in a Swiss clinic refuelled UK euthanasia debate Anne Turner's final trip to continental Europe was one she resented having to make.She loved travelling to Europe, often for the opera.But having decided to kill herself, she felt frustrated at the need to leave the comfort of her cosy bungalow in Bath.However, with typical self assurance, Dr Turner made precise plans.She would die in Switzerland on 24 January 2006, the day before her 67th birthday.Events early in the childhood of the woman dubbed "Boadicea" by a friend can probably be credited for the independence and strength of character that she exhibited throughout her life.Just 18 months after her birth in Harrogate in 1939, she was evacuated, with her sister, from war torn Europe to Vancouver in Canada.She only just made it.A German U boat sank the vessel behind the one in which she was travelling and such evacuations promptly ceased.But having safely reached North America, she enjoyed living with cousins and a grandmother.In 1945 however, she returned to Westerham, Kent, in England and to parents she didn't know-and to the austere, postwar landscape.She would later joke that it felt as if she had been evacuated to the United Kingdom rather than returned home.After her carefree existence in Canada, the grey skies, food rations, and lack of central heating did not endear her to her native land.Her father, a civil servant, and her mother, a local councillor, were strict and somewhat distant parents.So being packed off to boarding school in 1952 seemed more like a release than a frightening trip into the unknown.Shortly after leaving school a lifethreatening adder bite provided a first glimpse of her mortality.Her response was not fear but curiosity.And from this near-death experience she decided that dying was as easy as going to sleep.In 1958 she went to St Thomas' to study medicine.On the first day she met her future husband, Jack Turner.After qualifying, they worked in the south of England before settling in Bath, where they found jobs in general practice and began a family.Anne Turner soon developed an interest in family planning, and was to play a key role
House officer responses to impaired physicians
Authors: D. B. Reuben
Journal: JAMA (1990)

Although physician impairment may have substantial personal and clinical consequences, it is commonly held that physicians fail to act in the case of impaired colleagues. To learn about initial responses when confronted with impaired house officers and attending physicians, we administered five case scenarios to all 76 internal medicine house officers at a large, urban, teaching hospital. House officer responses to an alcohol-impaired physician differed depending on whether that physician was an attending physician or a house officer. Seventy-two percent of house officers would tell the chief resident about the alcohol-impaired attending physician, whereas 96% would confront the alcohol-impaired house officer personally. The most common response to the incompetent attending physician (67%) and the incompetent house officer (49%) was to tell the chief resident; only 25% would confront an incompetent house officer. In contrast, 71% would confront a depressed house officer. (<i>JAMA</i>. 1990;263:958-960)
THE BUSINESS SIDE OF MEDICINE IN CANADA.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal