tbuckley/cabot-search huggingface dataset:
Relationship of Aluminum to Alzheimer's Disease
Authors: Daniel P. Perl
Journal: Environmental Health Perspectives (1985)

Alzheimer's disease is a progressive degenerative brain disease of unknown etiology, characterized by the development of large numbers of neurofibrillary tangles and senile plaques in the brain. Aluminum salts may be used experimentally to produce lesions which are similar, but not identical, to the neurofibrillary tangle. Although some studies have reported increased amounts of aluminum in the brains of Alzheimer's disease victims, these bulk analysis studies have been difficult to replicate and remain controversial. Using scanning electron microscopy with X-ray spectrometry, we have investigated this question on the cellular level. We have identified abnormal accumulations of aluminum within neurons derived from Alzheimer's disease patients containing neurofibrillary tangles. Similar accumulations have been detected in the numerous neurofibrillary tangle-bearing neurons seen in the brains of the indigenous native population of the island of Guam who suffer from amyotrophic lateral sclerosis and parkinsonism with dementia. Epidemiologic evidence strongly suggests a causal role for local environmental conditions relating to availability of aluminum, calcium, and magnesium. In view of the fact that a major consequence of acid rain is the liberation of large amounts of aluminum in bioavailable forms, concerns are raised about possible human health risks of this environmental phenomenon.
Workforce Planning: Estimating Emergency Physicians and Uncovering Primary Care-Reply
Authors: John B. McCabe
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr Johnson appropriately points out some of the difficulties of the current workforce estimates in emergency medicine. The ACEP agrees that current data sources such as the AMA and AOA master files do not accurately reflect the number of physicians practicing emergency medicine today. Dr Kindig points out some of the reasons why such discrepancies might exist. The ACEP is also concerned that accurate data must be available to make accurate workforce predictions for the future of emergency medicine. To date, only crude estimates of the emergency physician workforce are available. If one assumes that there are approximately 5000 emergency departments in the country, and that approximately five FTE physician practitioners are required to staff a department 24 hours a day, then a simple estimate of approximately 25 000 emergency physician FTE practitioners can be easily arrived at. It is unclear at the present time whether these 25
Retinoid hepatitis
Authors: Miguel R. Sanchez, Bonnie Ross, Heidrun Rotterdam, James Salik, Rachella Brodie, Irwin M. Freedberg
Journal: Journal of the American Academy of Dermatology (1993)

A 65-year-old woman treated with etretinate for pityriasis rubra pilaris developed chronic active hepatitis. The elevated transaminases were noted 2 months after initiation of therapy and peaked 2 months after discontinuation of etretinate. The spectrum of liver toxicity induced by etretinate is reviewed. We suggest that reported cases of retinoid-induced liver disease can be divided into four distinct categories: nonspecific reactive hepatitis, acute hepatitis, chronic active hepatitis, and severe fibrosis or cirrhosis. A 65-year-old woman treated with etretinate for pityriasis rubra pilaris developed chronic active hepatitis. The elevated transaminases were noted 2 months after initiation of therapy and peaked 2 months after discontinuation of etretinate. The spectrum of liver toxicity induced by etretinate is reviewed. We suggest that reported cases of retinoid-induced liver disease can be divided into four distinct categories: nonspecific reactive hepatitis, acute hepatitis, chronic active hepatitis, and severe fibrosis or cirrhosis.
Thoracic Surgery
Authors: J. Gordon Scannell
Journal: New England Journal of Medicine (1956)

THE three years that have elapsed since the last progress report on thoracic surgery appeared in this journal have been a time of consolidation of past gains rather than of breaking new ground. Certainly this has been true so far as diseases of the lung are concerned. In the cardiovascular field considerable advance has been made.An example of such an advance is the changing attitude toward aneurysm of the thoracic aorta. Three years ago symptomatic therapy of thoracic aneurysms was accepted as the useful, if not ideal, method of management. Intrasaccular wiring had been shown to relieve pain in . . .
Renal Pyramidal Structure Opacification in Excretory Urography and Its Relation to Medullary Sponge Kidney
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Number of Sex Partners and Potential Risk of Sexual Exposure to Human Immunodeficiency Virus
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early detection of primary hepatocellular carcinoma. Screening for primary hepatocellular carcinoma among persons infected with hepatitis B virus
Authors: W. L. Heyward
Journal: JAMA (1985)

High rates of hepatitis B virus infection and primary hepatocellular carcinoma are present among Alaskan Natives. To determine if primary hepatocellular carcinoma could be detected at an early surgically resectable stage, serological screening for elevated α-fetoprotein levels was done semiannually among Alaskan Natives infected with hepatitis B virus. During a 26-month screening period, 3,387 α-fetoprotein tests were performed on 1,394 persons. Of 126 persons with elevated levels of α-fetoprotein (&gt;25 ng/mL), nine males were found to have primary hepatocellular carcinoma (all with α-fetoprotein levels &gt;350 ng/mL). Six of these nine persons were asymptomatic for primary hepatocellular carcinoma and four had small tumors (&lt;6 cm) that were surgically resected. After surgery, the α-fetoprotein levels in all four patients fell to normal and have remained normal after a follow-up of four to 20 months (median, ten months). α-Fetoprotein screening proved to be an effective approach in this population in detecting primary hepatocellular carcinoma at a potentially curable stage and should be considered in other individuals or populations infected with hepatitis B virus. (<i>JAMA</i>1985;254:3052-3054)
RESEARCHES IN HELMINTHOLOGY AND PARASITOLOGY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In vitro fertilization and alternatives
Authors: G. D. Hodgen
Journal: JAMA (1981)

PERHAPS as many as 500,000 American women are infertile as a result of Fallopian tube dysfunction. Because this represents an important national health problem, work in our laboratory has focused on novel approaches to alleviate such infertility, using nonhuman primate experimental models. The rationale for pursuing new experimental methods, as well as a summary of recent findings, may be of interest to medical practitioners treating and counseling such patients, as well as to infertility specialists in reproductive medicine. At the outset, it may be enlightening to compare the current situation in the treatment of women with irreparably blocked or missing Fallopian tubes with the major advances that have occurred during the past 20 years in the treatment of infertility resulting from anovulation. Principally, achievements in ovulation induction are the result of having developed four remarkably effective medicinal agents, acting either through the CNS (especially hypothalamic-pituitary centers) or within the ovaries
OP0086 Eular Recommendations for Women's Health and the Management of Family Planning, Assisted Reproduction, Pregnancy, and Menopause in Patients With Systemic Lupus Erythematosus and/or the Antiphospholipid Syndrome
Authors: L. Andreoli, G. Bertsias, N. Agmon-Levin, S. Brown, R. Cervera, N. Costedoat-Chalumeau, A. Doria, R. Fischer-Betz, F. Forger, M. Moraes-Fontes, M. Khamashta, J. King, A. Lojacono, F. Marchiori, P. Meroni, M. Mosca, M. Motta, M. Ostensen, C. Pamfil, L. Raio, M. Schneider, E. Svenungsson, M. Tektonidou, S. Yavuz, D. Boumpas, A. Tincani
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To develop recommendations for family planning, assisted reproduction, pregnancy, and menopause in women with SLE and/or APS. <h3>Methods</h3> Research questions were compiled using a modified Delphi technique. A systematic PubMed search was performed using an array of index terms. <h3>Results</h3> The preliminary set of recommendations are presented. SLE and/or APS patients planning a pregnancy should be counseled and managed after risk stratification by taking into consideration disease activity (active/flaring SLE, history of lupus nephritis or vascular/thrombotic events), serological profile (C3/C4, anti-dsDNA, anti-Ro/SSA, anti-La/SSB and antiphospholipid antibodies [aPL]), hypertension, and use of drugs (with emphasis on hydroxychloroquine (HCQ) and antiplatelet/anticoagulant therapy). SLE and/or APS women can be candidates for contraceptive measures based on their disease activity and thrombotic risk. Fertility preservation methods, especially GnRH analogues, should be considered prior to the use of alkylating agents. Assisted reproduction techniques seem to have comparable efficacy as in the general population, and can be safely used in patients with stable/inactive disease; patients with positive aPL/APS should receive appropriate anticoagulation and/or low dose aspirin. Disease activity, serological markers, and renal function parameters are useful to monitor for obstetrical adverse outcomes and disease flares during pregnancy. Fetal monitoring is similar to high-risk pregnancies including Doppler ultrasonography, particularly after 24-28 weeks of gestation to screen for placental insufficiency; fetal echocardiography is indicated for suspected fetal dysrhythmia, especially in patients with positive anti-Ro and/or anti-La. HCQ, glucocorticoids (oral/intravenous pulse), azathioprine, cyclosporine-A, tacrolimus and intravenous immunoglobulin can be used to prevent or manage SLE flares during pregnancy. If stable/inactive disease and negative aPL, hormonal replacement therapy can be used for severe vasomotor menopausal manifestations. Screening for malignancies is similar to the general population, with vigilance for cervical pre-malignant lesions if exposed to immunosuppressive drugs. Similar to the general population, HPV immunization should be considered in women with stable/inactive disease. <h3>Conclusions</h3> Recommendations for women9s health and pregnancy in SLE and/or APS patients were developed by evidence-based and expert consensus. <h3>Disclosure of Interest</h3> None declared
Pressor Amines and the Carcinoid Flush
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thunderstorm outflows preceding epidemics of asthma during spring and summer
Authors: G B Marks, J R Colquhoun, S T Girgis, M Hjelmroos Koski, A B A Treloar, P Hansen, S H Downs, N G Car
Journal: Thorax (2001)

BACKGROUND A study was undertaken to assess the importance of thunderstorms as a cause of epidemics of asthma exacerbations and to investigate the underlying mechanism. METHODS A case control study was performed in six towns in south eastern Australia. Epidemic case days (n = 48) and a random sample of control days (n = 191) were identified by reference to the difference between the observed and expected number of emergency department attendances for asthma. The occurrence of thunderstorms, their associated outflows and cold fronts were ascertained, blind to case status, for each of these days. In addition, the relation of hourly pollen counts to automatic weather station data was examined in detail for the period around one severe epidemic of asthma exacerbations. The main outcome measure was the number of epidemics of asthma exacerbations. RESULTS Thunderstorm outflows were detected on 33% of epidemic days and only 3% of control days (odds ratio 15.0, 95% confidence interval 6.0 to 37.6). The association was strongest in late spring and summer. Detailed examination of one severe epidemic showed that its onset coincided with the arrival of the thunderstorm outflow and a 4–12 fold increase in the ambient concentration of grass pollen grains. CONCLUSIONS These findings are consistent with the hypothesis that some epidemics of exacerbations of asthma are caused by high concentrations of allergenic particles produced by an outflow of colder air, associated with the downdraught from a thunderstorm, sweeping up pollen grains and particles and then concentrating them in a shallow band of air at ground level. This is a common cause of exacerbations of asthma during the pollen season.
It's time to wake up to the importance of sleep disorders
Authors: W. C. Dement
Journal: JAMA (1993)

STUDIES indicate that as many as 80 million Americans who have serious, incapacitating sleep problems are being ignored—either because they do not report their symptoms or because physicians do not ask.<sup>1,2</sup>Treatment of sleep complaints, such as insomnia, and sleep disorders, such as sleep apnea, are compromised by this apathy. The National Commission on Sleep Disorders Research, which was charged by a 1988 congressional mandate to evaluate the effect of sleep deprivation on American society, found that 95% of the 5 million to 10 million Americans with sleep apnea do not know they have sleep apnea and consequently face cardiovascular complications and sudden death.<sup>1</sup>Even snoring, a phenomenon often thought of by those affected as benign, is associated with poor prognosis in individuals who are at risk for cardiovascular disease<sup>3</sup>and also can increase risk of stroke.<sup>4</sup>Individuals with chronic insomnia report 2.5 times as many
The Surgical Significance of Jejunal Diverticulosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PRINCIPLES OF ETHICS OF THE AMERICAN MEDICAL ASSOCIATION
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Authors: Md Griffiths, W Adams, Philip Harris, J Abercrombie, London Addiscott, B Addy, D Aitken, R Anderson, C Aitken, J Arnott, Rev Brooks, B Bull, Gottingen Blackstein, Mrs Behnke, W Clapham, A Coldstream, Florence Cumberland, A Churchill, ; Cowan, W Calvert, A Dimmock, R Dove
Journal: BMJ (1898)

f Queries, answers, and communications relating to subjects to whic special department. of the BRITISH M1EDICAL JOuIRNAL are drected wiU be found under their respective headings.4UIERIES. DR. BOND (Gloucester
Exposure to Infant Siblings During Early Life and Risk of Multiple Sclerosis—Reply
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Do Large-Scale Remedial and Dredging Events Have the Potential to Release Significant Amounts of Semivolatile Compounds to the Atmosphere?
Authors: Jeff Chiarenzelli, Ronald Scrudato, Brian Bush, David Carpenter, Sean Bushart
Journal: Environmental Health Perspectives (1998)

Laboratory studies suggest that substantial amounts of polychlorinated biphenyls are rapidly volatilized from wet contaminated solids during water evaporation. If significant losses also occur during field activities, potential analytical, global, and health implications should be considered in the design and monitoring of remedial actions and the handling of contaminated solids.