tbuckley/cabot-search huggingface dataset:
Perfume Dermatitis
Authors: Thomas D. Parks
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Drs. Keith, Reich, and Bush (<b>209</b>:269, 1969) reported dermatitis in the anogenital region and coincident use of perfumed toilet paper. They did not conduct patch tests. It seems unlikely that the perfume in toilet paper could cause any effect as all of it reaches the paper by diffusion. The method of perfuming a toilet-paper roll involves placing the perfume on the inner core, not on the paper itself. The amount of perfume thus added amounts to less than 0.02% of the weight of the roll. The high incidence (4%) of patients who reacted to perfumes in patch tests by Rothenborg and Hjorth must be viewed in context.<sup>1</sup>All of these subjects were already afflicted with dermatitis. They were challenged with 5% solution of perfume which is about 5 times that found in the usual toilet soap and more than 250 times that added to toilet
Living Wishes
Authors: Adam B Possner
Journal: Annals of Internal Medicine (2010)

On Being a Doctor7 December 2010Living WishesAdam B. Possner, MDAdam B. Possner, MDFrom Johns Hopkins Bayview Medical Center, Baltimore, MD 21224.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-11-201012070-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The triage paperwork outside the clinic exam room was customarily terse: “Joann Williams, 45-year-old new patient, recently hospitalized.”Inside, a slender woman with a narrow face, caramel-colored skin, and black curly hair cut close to her scalp waited. Sitting beside her, his feet dangling, was a 6- or 7-year-old boy, his features echoing hers.I had barely shaken her hand before Ms. Williams cut to the chase. “Doc,” she declared in a hoarse voice surprisingly large for her size, “I haven't always followed up, but I'm gonna follow up now.”A review of her record showed that she had first ... Author, Article, and Disclosure InformationAuthors: Adam B. Possner, MDAffiliations: From Johns Hopkins Bayview Medical Center, Baltimore, MD 21224.Corresponding Author: Adam B. Possner, MD, Medical Faculty Associates at George Washington University, 2150 Pennsylvania Avenue NW, Suite 2-105 South, Washington, DC 20037; e-mail, apossner@mfa.gwu.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 December 2010Volume 153, Issue 11 Page: 761-762 Keywords Chemotherapy Computed axial tomography Hospitalizations Pyelonephritis Ribs Shoulders Surgery Triage Ventilators Walking ePublished: 7 December 2010 Issue Published: 7 December 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE WAR AND MEDICAL EDUCATION
Authors: W. H. B.
Journal: Annals of Internal Medicine (1942)

Editorial1 November 1942THE WAR AND MEDICAL EDUCATIONW. H. B.W. H. B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-5-874 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough our country has been at war less than a year, extensive changes in medical education have already been instituted in order to meet special conditions created by the immediate needs of our armed forces. These changes are both quantitative and qualitative in character.The principal quantitative change that has been put into effect is the adoption by the majority of medical schools of an accelerated program whereby the medical course is shortened from four to three calendar years. This means that the four academic years can now be completed within three calendar years by continuous instruction throughout the summer... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1942Volume 17, Issue 5Page: 874-876KeywordsArmed forcesMedical education ePublished: 1 December 2008 Issue Published: 1 November 1942 PDF downloadLoading ...
Postmortem Facies
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Ghost
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2015)

Ad Libitum18 August 2015The GhostJack Coulehan, MD, MPHJack Coulehan, MD, MPHFrom Setauket, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-1468 Audio Reading - “The Ghost” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Ghost," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail He's got yellowing ... Author, Article, and Disclosure InformationAffiliations: From Setauket, New York.Current Author Address: Jack Coulehan, MD, MPH; e-mail, John.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “The Ghost” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "The Ghost," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 18 August 2015Volume 163, Issue 4Page: 297KeywordsBloodLiverMouthSleep ePublished: 18 August 2015 Issue Published: 18 August 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PDIGREE: An adaptive phase III trial of PD-inhibitor nivolumab and ipilimumab (IPI-NIVO) with VEGF TKI cabozantinib (CABO) in metastatic untreated renal cell cancer (Alliance A031704).
Authors: Tian Zhang, Karla V. Ballman, Atish Dipankar Choudhury, Ronald C. Chen, Colleen Watt, Yujia Wen, Ardaman Shergill, Tyler J. Zemla, Hamid Emamekhoo, Ulka N. Vaishampayan, Michael J. Morris, Daniel J. George, Toni K. Choueiri
Journal: Journal of Clinical Oncology (2021)

TPS366 Background: First-line treatment of mRCC has rapidly changed to include IPI-NIVO or CABO, with clinical benefit of each based on the Checkmate 214 and CABOSUN (A031203) trials. Combination immunotherapy with VEGF therapies has shown benefit over sunitinib in the JAVELIN 101 and KEYNOTE 426 trials. It is yet unclear which patients (pts) benefit most from combination immunotherapy-VEGF inhibitors, and the optimal sequence of drugs. Methods: In an adaptive, randomized, multicenter phase III trial (Alliance A031704, PDIGREE), pts start treatment with induction IPI 1 mg/kg and NIVO 3 mg/kg intravenously (IV) once every 3 weeks. Key inclusion criteria include clear cell mRCC, International Metastatic RCC Database Consortium (IMDC) intermediate or poor risk, Karnofsky performance status &gt;70, and no prior treatments for mRCC. Based on 3-month radiographic assessment (after completing IPI-NIVO combination), pts with complete responses (CR) undergo maintenance NIVO 480 mg IV every 4 weeks; pts with progression of disease (PD) switch to CABO 60 mg oral daily; pts with non-CR/non-PD are randomized to NIVO 480 mg IV every 4 weeks versus NIVO 480 mg IV every 4 weeks with CABO 40 mg oral daily. Randomization is stratified by IMDC risk criteria and presence of bone metastases. The primary endpoint of the study is overall survival (OS). We hypothesize that 3-year OS will improve to 70% for NIVO-CABO compared to 60% for NIVO alone; to achieve 85% power with a two-sided alpha of 0.05 and exponential distribution, 696 patients will be randomized. Accounting for 30% patients with either CR or PD, and 5% dropout from toxicity, up to 1046 pts will be enrolled. Key secondary endpoints include progression-free survival, 12-month CR rate, overall response rate based on RECIST 1.1 and iRECIST criteria, and toxicity profiles. Quality of life will be assessed based on the FKSI-19, PROMIS-fatigue, and EQ5D-5L questionnaires. Biomarkers associated with CR, tissue-based and plasma-based biomarkers will be assessed. Updated enrollment through January 2021 will be presented. Clinical trial information: NCT03793166 .
Fat Embolism
Authors: Otto E. Aufranc
Journal: JAMA (1970)

Dr. Stuart Cope: The patient is a 25-year-old man who was in an automobile accident in July 1967. He was brought in to a local hospital and examined. His injuries consisted of closed fractures of the right femur in its distal third (Fig 1, left), and closed fractures of the right tibia and fibula (Fig 1, right). His general condition was good. He had no head or trunk injuries. The results of his neurological examination were normal, and the circulation in his right lower extremity was intact. He was admitted to the hospital, and his right lower extremity was placed in balanced suspension, with a short leg cast incorporating a Kirschner wire in the proximal tibia. Twelve hours after admission he became comatose and dyspneic. During physical examination, petechial hemorrhages were noted on his chest. There was an abrupt fall in his hematocrit value and an abnormal x-ray film of
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Kevin Brown, Amanda Ehrhardt, Iris Lo, Michaela Mark, M Newman, Suzanne Walker, Connie Manno, Sara Billings, Timothy Gray, Paul Ruich, Catherine Copyreaders, Stephanie Alden, Jane Beckmeyer, Jan Calayag, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Brandy King, Donna Patton, Editorial Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Fanny Brown, Lenette Gardner-Gullens, Erin Kato, Peter Kim, Rachell Lozano, Caroline Sietmann, Angelia Waltower, Elizabeth Scientifi, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Carrie Butt, Mary Ferkaluk, Emily Ling, Jesse Mcquarters, Daniel Morrow, Reuben Rios, Ronna Henry, Karen Bucher, Andy Rekito, Nick Reback, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Managers, Rick Bell, Fergus Clare, Lindsay Dawson, Will English, Ellen Gibson, Mustafa Ishaq, Craig Mccaff Rey, Michael Mcgraw, Daniel Pickhardt, Romando Rossini, Stacy Business, Analyst Sirisha, Alluri Staff, Millette Jackson-Bates, Karl Elvin, Nancy Essex, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Jordynn Farrar, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Binita Shah, Denise Steinhauser, Erin Van Dusen, Joe Advertising, Production Services, Ahmed Avendano, Kim Boler, Rhonda Brown, Fin Carter, Michael Deegan, Daniel Degroot, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Mary Sieck, Sarah Subramanian, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son Diggs, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Dan Blazer, North Carolina, David Braff, La Jolla, Stephen California, Washington Dager, Atlanta Druss, Susan Georgia, New Essock, New York, Ellen York, James Frank, Maryland Harris, S Kenneth, Virginia Kendler, C Ronald, Kathleen Kessler, Maryland Merikangas, Judith Samples O'malley, Maryland Rapoport, F Charles, Myrna Reynolds, New Weissman, Charles York, St Zorumski, Shitij Kapur, Michael Owen, Fmed Sci, Naomi Wray, Roy Grinker Sr, Daniel Freedman, Jack Barchas, Joseph Coyle, Constance Murphy, Martin Paulus, Christine Konradi, Helena Chmura Kraemer, Palo Alto, Howard Bauchner, Dost Ongür
Journal: JAMA Psychiatry (2018)
Technique Manages Chronic Uremia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Legionnaires' Disease
Authors: Gary L. Lattimer
Journal: JAMA (1978)

The cases of six patients with Philadelphia Legionnaires' disease were studied during the acute phase and throughout the following year. This multisystems disease process developed abruptly with symptoms of chills, fever, myalgias, and headache. The unusual clinical association of fever with relative bradycardia was noted frequently. Pneumonia developed after the first few days and rapidly progressed to life-threatening respiratory failure despite penicillin and cephalosporin therapy. Improvement occurred within 48 hours after tetracycline or chloramphenicol was administered. No permanent sequelae were noted on the one-year follow-up examination, and no secondary cases of infection occurred. (<i>JAMA</i>240:1169-1171, 1978)
Technische Operationen in der Orthopädie (Orthokinetik).
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Public opinion and AIDS. Lessons for the second decade
Authors: R. J. Blendon
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effects of early corticosteroid therapy on the skin eruption and pain of herpes zoster
Authors: W. H. Eaglstein
Journal: JAMA (1970)

Healthy patients with early painful herpes zoster were treated with corticosteroid orally or lactose tablets in a double-blind fashion. The duration of postherpetic neuralgia was shortened by treatment with the corticosteroid. Corticosteroid therapy did not affect pain during the first two weeks or the rate of skin healing. The duration of postherpetic neuralgia could not be predicted by the healing rate of the skin. Control patients less than 60 years old had rapid resolution of their neuralgia while those more than 60 years old had slower resolution of the pain. Corticosteroid therapy did not cause generalization of the eruption.
Deaths from hypothermia
Authors: R. E. Zumwalt
Journal: JAMA (1986)

<h3>In Reply.—</h3> The concern expressed by Drs Zumwalt and Kicklighter that death certificates may not reflect the true incidence of hypothermia-associated deaths is also applicable to other causes of death. Death certificates have long been used as a surveillance tool in epidemiology, and their limitations are well known. These limitations, however, affected neither our objectives nor the conclusions we reached. Any adjustment for underascertainment of cases increases rather than decreases the importance of this public health problem, and we welcome any suggestions for improving the accuracy of effect estimates for mortality statistics, especially for hypothermia. We agree that bias may be expected among mortality statistics, but we disagree with several conclusions in their letter. On the basis of pathological considerations, they contend that hypothermia is a mechanism and not a legitimate cause of death. Protocols for completing and coding death certificates, however, do identify hypothermia as a cause of death
Relative Roles of Metabolism and Renal Excretory Mechanisms in Xenobiotic Elimination by Fish
Authors: John B. Pritchard, John R. Bend
Journal: Environmental Health Perspectives (1991)

Renal clearance techniques were used to examine the relative contributions of metabolism and renal tubular transport in determining the rates ofexcretion of benzo(a)pyrene (BaP) and several ofits phase I metabolites by southern flounder, Pmlichrhys kthoslgma.Each compound (31H-labeled) was injeted at a dose of2.5 gnole/kg, producing plasma concen- trations of 1 to 5 sM.Despite extensive plasma binding (>95%), the uncorrectd renal clearance of BaP-7$-dihydrodiol exceeded the glomerular filtration rate (GFR) by more than 20-fold.Phenolic BaP metabolites also showed net secretion (1.5-to 3-fold).At times prior to 3 hr, BaP itselfshowed an average clearance ofonly 02 times the GFR.After 3 hr, BaP cearance increased to three times the GFR.Decasing the dose ofBaP ijet also dramatically incesed its learance.Clearances ofall four compounds studied were reduced by probenecid and otber organic anion, including the herbicide 24-dichlorophenoxyacetic acid.HPLC analysis demonstrated that the bulk ofthe material excreted in the urine was not the parent compound, but sulfte or glucurnid conjugates ofits phenolic or dihydrodiolmeaites.Excretion ofsulfate conjugates predominated over the first 24 hr, whereas the glucuronide conjugates were the primary excretory products in succeeding days.In vitro, isolated renal tubules trnsported both glucuronide and sulfate conjuptes, but sulfates were the preferred substrates.Isolated tubules were shown to be capable of catalyzing conjugation reactions, producing predominantly glucuronide conjugates.Liver slices produced both types of conjugates.Thus, the rapid excretion of BaP-7,8dihydrodiol reflected a combination of two processes.First, this metabolite was rapidly converted to its sulfate conjugate, pimarily via etnrenal tissues.Second, the sulfate conjugate was preferentially transported to the urine yia secretion on the organic anion transport system.
A new scoring system determines risk of cardiovascular disease
Journal: BMJ (2001)

Helicobacter pylori testing is useful only in high risk patientsHelicobacter pylori testing in primary care is useful only in those at higher risk of developing peptic ulcer disease and is of no value in those at lower risk Three simple points from a patient's history-smoking, pain on an empty stomach, and history of peptic ulcer disease-can distinguish between those at high risk and those at low risk of peptic ulcer disease.In their cross sectional study of 565 primary care patients in the Netherlands, Weijnen and colleagues (p 71) found that these three variables had odds ratios of 5.5, 2.8, and 2.0 respectively.In those found to be at higher risk using this scoring rule, the predictive value for the presence of peptic ulcer disease increased from 16% to 26% after a positive Helicobacter pylori test.