tbuckley/cabot-search huggingface dataset:
Pain
Authors: Sigrun Susan Lane
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myxomatosis
Authors: Roy E. Ritts
Journal: JAMA (1966)

<i>Myxomatosis</i>is not only the definitive work on this fascinating viral disease and its natural host, the rabbit, but also an eminently readable account of the most thoroughly controlled and studied ecological experiments in history. The book's real charm is that Professor Fenner and Mr. Ratcliffe were principal players in this drama and have been able to present the history, economics, politics, and geography as well as the host-parasite-environment complex in a manner so lucid that<i>Myxomatosis</i>must become a bench mark in scientific writing. While Dr. Fenner does mention some of his own studies and both authors are included in a group picture entitled "Scientists who have been concerned with the investigation of myxomatosis in Australia and America," they have been unduly modest about their important roles. Every reader may find a few personal reservations, eg, the political forces portrayed are necessarily seen through the eyes of a medical
Reconstitution of bile acid transport in the rat hepatoma McArdle RH- 7777 cell line
Authors: E Torchia
Journal: Hepatology (1996)

The liver recovers bile acids from the portal circulation primarily via an active process that is dependent on sodium ions. Hepatocytes lose the ability to transport bile acids in culture, and, in liver-derived permanent cell lines, this ability is severely reduced or absent. To study the importance of bile acids in regulating liver-specific functions (e.g., cellular bile acid and cholesterol metabolism), we have re-established active bile acid transport in cultured cells. The complementary DNA (cDNA) encoding the rat sodium/taurocholate cotransporting polypeptide (ntcp) was placed under the control of a cytomegalovirus promoter and transfected into the rat hepatoma cell line, McArdle RH-7777. Transfected cells were screened for the ability to take up [3H]-taurocholate. Clones that displayed the ability to take up taurocholate were expanded (designated McNtcp) and further characterized. The apparent Michaelis constant (Km) for taurocholate uptake was similar among the different clones. The observed maximum velocity (Vmax), however, differed and was positively correlated with the abundance of recombinant ntcp messenger RNA (mRNA). The highest level of taurocholate uptake activity observed in McNtcp cells was comparable with that of freshly isolated hepatocytes. Efflux of accumulated taurocholate from McNtcp cells proceeded in a manner similar to primary hepatocytes, indicating that McArdle RH-7777 cells have retained the ability to secrete bile acids. Moreover, taurocholate uptake in McNtcp cells was inhibited by other bile acid species. Based on the observed kinetic parameters, the reconstituted McArdle RH-7777 cells mimic the ability of primary hepatocytes to transport bile acids.
Journal of Pathology, New York
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk of agranulocytosis and aplastic anaemia in relation to use of antithyroid drugs. International Agranulocytosis and Aplastic Anaemia Study.
Authors: George Retsagi, Judith Kelly, David Kaufman
Journal: BMJ (1988)

The relation of the use of antithyroid drugs to the risk of developing agranulocytosis and aplastic anaemia was evaluated in a population based case-control study with patients from Israel and seven regions in Europe. Data were obtained from cases and hospital controls by interview. Use of antithyroid drugs in the week before the onset of illness was compared in 262 patients with agranulocytosis and 1771 controls. Forty five patients (17%) and five controls (0.3%) had used antithyroid drugs. The relative risk was estimated to be 102 (95% confidence interval 38 to 275) taking into account confounding by other factors, including the use of other drugs. The excess risk for use of antithyroid drugs in any one week was estimated to be 6.3 cases of agranulocytosis per million users. Use of antithyroid drugs in a five month period ending one month before admission to hospital was compared in 135 patients with aplastic anaemia and 2145 controls. Four patients (3%) and five controls (0.2%) had taken drugs; the estimate of relative risk was 9.2 (95% confidence interval 1.8 to 47) after control for confounding. The estimate of excess risk of agranulocytosis with the use of antithyroid drugs was lower than found previously. Although the excess risk for aplastic anaemia was not calculated, these data suggest that it is very low.
Developmental Abnormalities of the Gonad and Abnormal Sex Hormone Concentrations in Juvenile Alligators from Contaminated and Control Lakes in Florida
Authors: Louis J. Guillette, Timothy S. Gross, Greg R. Masson, John M. Matter, H. Franklin Percival, Allan R. Woodward
Journal: Environmental Health Perspectives (1994)

The reproductive development of alligators from a contaminated and a control lake in central Florida was examined. Lake Apopka is adjacent to an EPA Superfund site, listed due to an extensive spill of dicofol and DDT or its metabolites. These compounds can act as estrogens. Contaminants in the lake also have been derived from extensive agricultural activities around the lake that continue today and a sewage treatment facility associated with the city of Winter Garden, Florida. We examined the hypothesis that an estrogenic contaminant has caused the current failure in recruitment of alligators on Lake Apopka. Supporting data include the following: At 6 months of age, female alligators from Lake Apopka had plasma estradiol-17 beta concentrations almost two times greater than normal females from the control lake, Lake Woodruff. The Apopka females exhibited abnormal ovarian morphology with large numbers of polyovular follicles and polynuclear oocytes. Male juvenile alligators had significantly depressed plasma testosterone concentrations comparable to levels observed in normal Lake Woodruff females but more than three times lower than normal Lake Woodruff males. Additionally, males from Lake Apopka had poorly organized testes and abnormally small phalli. The differences between lakes and sexes in plasma hormone concentrations of juvenile alligators remain even after stimulation with luteinizing hormone. Our data suggest that the gonads of juveniles from Lake Apopka have been permanently modified in ovo, so that normal steroidogenesis is not possible, and thus normal sexual maturation is unlikely.
Practical Aspects of Oxalate Metabolism
Authors: Harold Jeghers, Rosemary Murphy
Journal: New England Journal of Medicine (1945)

THERE are a wide variety of substances involved in human nutrition. The extensive literature dealing with the more important ones —vitamins, proteins, iron, glucose and so forth —tends to overshadow the modest literature concerning a wide range of less known and often less important substances of nutritional significance. As a result, many physicians fail to give them even the limited attention they deserve. Therefore, it is well periodically to re-emphasize subjects that are in general poorly understood.Many common foods contain organic acids. Citric, malic, oxalic, tartaric, benzoic, lactic, isocitric, malonic, succinic, aconitic, tricarballylic, salicylic, quinic and glyoxylic acids are . . .
Photosensitizers
Authors: IRVIN I. LUBOWE
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Much of the incidence of photosensitivity is due to an antigen-antibody reaction mediated by the sun. It seems only reasonable to me that purchasers of suntan lotions or sun blocks become captive consumers. Dr. Alexander Fisher states that vacationers are captive users of soap containing halogenated salicylanilides supplied by the hotels. I believe that all sunscreen lotions and sun blocks should not contain perfumes that might be responsible for photosensitivity in the heliophiles.
Abstract 6: Coronary Artery Involvement In Children With Kawasaki Disease In A Northern Region Of Italy In 13 Years
Authors: Marianna Fabi, Luca Pierantoni, Elisa Mazzoni, Chiara Landini, Francesca Lami, Giorgia Di Fazzio, Maria Chiara Casadei, Barbara Bigucci, Gabriella Testa, Alessia Palladini, Cristina Cicero, Paola Sogno Vallin, Elena Corinaldesi
Journal: Circulation (2015)

Objective: to evaluate the incidence of coronary anomalies (CAA) and risk factors for coronary involvement in children with KD from 2000 through 2013 in Emilia-Romagna. Design: an 11-centers retrospective study was conducted using data from 132 patients diagnosed with KD. Results: during the acute phase, CAA developed in 13/132 pts (9.8%): 2 pts had isolated ectasia of right coronary artery (RCA), 10 pts had ectasia of left anterior descending CA (LAD), 1 pt had aneurysm of LAD, 1 pt had ectasia of circonflex CA (CX). During the subacute phase 14/117 pts (11.9%) presented CAA: 3 had aneurysm of LAD, 1 had aneurysm of LAD and RCA, 1 had isolated ectasia of RCA, 9 had ectasia of LAD. During the convalescent phase CAA were detected in 18/83 pts (21%): 3 had aneurysm of LAD and RCA, 2 isolated aneurysm of LAD, 1 had aneurysm of RCA, 12 ectasia of LAD. 3 out of 6 aneurysms detected in theconvalescent phase developed in the subacute stage. Univariate analyses identified WBC and RBC in the subacute phase, and PLT in chronic phase as predictors of chronic CAA (respectively p 0.04, 0.013 and 0.002). A multivariate logistic regression analysis revealed that only PLT of the chronic stage was predictor for chronic CAA. ROC curve for PLT identified a value superior to 652000/mm3 to be the cut off value for CAA, with an 72% sensitvity and 87% specificity. Incomplete or atipical clinical presentation was correlated with CAA (p 0.02). Younger age (&lt; 1 yr) at diagnosis, seasonal distribution, IVIG responsivness, race, elevation of ALT, percentage of neutrophil, hemoglobin, CRP and ESR, albumin and sodium were not correlated with risk for CAL. Conclusions: atipical/incomplete clinical presentation, higher WBC and RBC in the subacute phase and PLT of the convalescent phase were predictors of CAA in our region, while blood exams of the acute stage, IVIG responsivness, sex and younger age were not.
Updated efficacy and safety of entrectinib in patients with NTRK fusion-positive tumours: Integrated analysis of STARTRK-2, STARTRK-1 and ALKA-372-001
Authors: C. Rolfo, R. Dziadziuszko, R.C. Doebele, G. Demetri, B. Simmons, A. Aziez, X. Huang, S. Osborne, L. Paz-Ares
Journal: Annals of Oncology (2019)
Table of contents
Authors: Matthew Hulver, Ousama Saleh, Kenneth Macdonald, Walter Pories, Hisham Barakat, Delphine Stoll, Christophe Binnert, Vincent Mooser, Luc Tappy, P Franks, J Luan, P Browne, A.-H Harding, S O'rahilly, V Chatterjee, N Wareham, C Albrecht, I Simon-Vermot, J Elliott, C Higgins, D Johnston, J Valabhji, K Koshinaka, Y Oshida, Y-Q Han, I Ohsawa, Y Sato, Keiko Arai, Tomoko Soga, Hisayuki Ohata, Asuka Otagiri, Tamotsu Shibasaki, Kristin Best, Karen Mccoy, Susan Gemma, Robert Disilvestro, Akira Honda, Tadashi Yoshida, Guorong Xu, Yasushi Matsuzaki, Sugano Fukushima, Naomi Tanaka, Mikio Doy, Sarah Shefer, Gerald Salen, Christiane Geluk, J Constantijn, Peter Halkes, Thijs De Jaegere, Manuel Plokker
Journal: Metabolism (2003)
Steroid Cataract
Authors: C. Fürst, W. K. Smiley, B. M. Ansell
Journal: Annals of the Rheumatic Diseases (1966)

Criteria for diagnosis of definite Still's disease.Onset of polyarthritis before the age of 16 years involving four or more joints for a minimum of 3 months or, when less than four joints are involved, a biopsy of synovial membrane showing histology compatible with a diagnosis of rheumatoid arthritis in the absence of evidence of other related diseases, such as rheumatic fever, psoriasis, systemic lupus erythematosus, etc.
Incorrect Wording
Authors: Dean Schillinger, David Ofman
Journal: JAMA (1998)

plans is unknown, but the results of the study by Soumerai et al 2 and our own experience suggest either approach would be cost saving in the long run, and improve quality of care.Epstein suggests that measuring quality of care at the plan level will be an increasingly sophisticated part of the state's oversight activities.As Medicaid managed care expands to include more patients with disabling illnesses, we would hope that the relatively practical issue of adequate medication dispensing is included as a top priority when states are generating contract requirements and making purchasing decisions.
Abstract 840: Identification of novel colorectal tumor suppressor genes through genome-wide promoter hypermethylation analysis
Authors: Sarah Bazzocco, Jose Higinio Dopeso, Águeda Martínez-Barriocanal, Estefanía Anguita, Rocio Nieto, Alex Sanchez, John M. Mariadason, Diego Arango
Journal: Cancer Research (2019)

Abstract Cancer initiation and progression are driven by both genetic and epigenetic changes. Although recent genome/exome sequencing efforts have significantly contributed to the thorough characterization of the genetic changes associated with the oncogenic process, further investigation is required to systematically identify the driver genes regulated by promoter hypermethylation. Using genome-wide analysis of the levels of promoter methylation (HumanMethylation27, Illumina) and the levels of mRNA expression (microarray analysis) in a panel of 30 colorectal cancer cell lines and 223 primary colorectal tumors (TCGA), we found a subset of 553 (5.6%) genes whose levels of promoter methylation showed a significant negative association with their expression. Higher overall methylation levels were associated with microsatellite instability (MSI), a CpG methylator phenotype (CIMP), faster proliferation and absence of APC mutations. Next, because genes that are epigenetically silenced could represent important drivers of the oncogenic process we investigated the role of the zinc finger transcriptional regulator ZNF238/ZBTB18, a gene silenced by promoter methylation, on the growth of colon cancer cells. Reintroduction of ZNF238 in HCT116 and HT29 colon cancer cells with low endogenous levels and promoter methylation of ZNF238, resulted in a significant reduction of cell proliferation both in vitro and in a subcutaneous xenograft NOD/SCID mouse model. Moreover, using immunohistochemical analysis with a validated antibody we found that ZNF238 is lost or reduced in the majority of the 133 primary colorectal tumors included in a tissue microarray, and that lower ZNF238 expression is associated with lymph node metastasis and shorter survival of patients with locally advanced colorectal cancer. In summary, we identified a set of 553 genes putatively silenced by promoter methylation in colorectal tumors that could significantly contribute to the oncogenic process. Moreover, as a proof of concept, we demonstrate that the epigenetically silenced gene ZNF238 has tumor suppressor activity and is associated with the survival of colorectal cancer patients. Citation Format: Sarah Bazzocco, Jose Higinio Dopeso, Águeda Martínez-Barriocanal, Estefanía Anguita, Rocio Nieto, Alex Sanchez, John M. Mariadason, Diego Arango. Identification of novel colorectal tumor suppressor genes through genome-wide promoter hypermethylation analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 840.
Infectious diseases in competitive sports
Authors: R. A. Goodman
Journal: JAMA (1994)

<h3>Objective.</h3> —Participation in competitive sports is popular and widely encouraged throughout the United States. Reports of infectious disease outbreaks among competitive athletes and recent publicity regarding infectious disease concerns in sports underscore the need to better characterize the occurrence of these problems. <h3>Data Sources.</h3> —To identify reports of infectious diseases in sports, we performed a comprehensive search of the medical literature (MEDLINE) and newspaper databases in two on-line services (NEXIS and DIALOG PAPERS). <h3>Study Selection.</h3> —Articles selected from the literature review included those describing cases or outbreaks of disease in which exposure to an infectious agent was likely to have occurred during training for competitive sports or during actual competition. Articles from the newspaper review included reports of outbreaks, exposures, or preventive measures that directly or indirectly involved teams or spectators. <h3>Data Synthesis.</h3> —The literature review identified 38 reports of infectious disease outbreaks or other instances of transmission through person-to-person (24 reports), common-source (nine reports), or airborne (five reports) routes; the newspaper search identified 28 reports. Infectious agents included predominantly viruses but also a variety of fungi and gram-positive and gram-negative bacteria. <h3>Conclusions.</h3> —Our findings indicate that strategies to prevent transmission of infectious diseases in sports must recognize risks at three levels: the individual athlete, the team, and spectators or others who may become exposed to infectious diseases as a result of sports-related activities. Team physicians and others who are responsible for the health of athletes should be especially familiar with the features of infectious diseases that occur in sports and measures for the prevention of these problems. (<i>JAMA</i>. 1994;271:862-867)
More Snakes
Authors: Milan L. Hopkins
Journal: JAMA (1985)

<h3>To the Editor.—</h3> I read with interest Dr Rakel's comments on the relative merits of Aesculapius' staff and the caduceus. Has anyone noticed how frequently representations of the staff feature a short but prominent branch near the top? Any boy scout knows that a forked stick is the appropriate tool for controlling a venomous serpent. What more concise and graphic symbol for the healing art?
Listerial prosthetic valve endocarditis. Successful medical therapy
Authors: L. D. Saravolatz
Journal: JAMA (1978)

LISTERIA monocytogenes endocarditis is an extremely rare entity with, to our knowledge, only 13 cases reported since 1955.<sup>1,2</sup>Unlike other cases of listeriosis, endocarditis caused by this organism does not preferentially occur in immunosuppressed patients. To our knowledge, this communication describes the first successfully treated case of<i>L monocytogenes</i>endocarditis involving a prosthetic heart valve. Also presented are in vitro studies showing synergy with penicillin G potassium and tobramycin sulfate and with other antibiotics that might be useful in the penicillin-allergic patient. Such treatment programs may show greater bactericidal activity and less toxic reaction than those using older aminoglycosides, ie, kanamycin sulfate or streptomycin sulfate. <h3>Materials and Methods</h3> The blood culture isolates were identified as<i>L monocytogenes</i>since they were catalase-positive, pleomorphic, nonsporing Gram-positive rods. They exhibited a characteristic end-over-end tumbling motility at 20 to 25 °C and a narrow ring of β-hemolysis on blood agar. The minimal inhibitory
"SARCOIDOSIS AND MIF GENE POLYMORPHISM: A CASE CONTROL STUDY IN AN IRISH POPULATION". B.J. PLANT, S. GHANI, M.J. O'MAHONY, L. MORGAN, C.M. O'CONNOR, K. MORGAN, J.A. BAUGH AND S.C. DONNELLY. EUR RESPIR J 2007; 29: 325 329.
Journal: European Respiratory Journal (2007)
How far should a physiatrist go?
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I have received numerous telephone calls and letters from constituents in my academy responding to the review by Edward A. Edwards, MD,<sup>1</sup>of the book<i>Medical Rehabilitation</i>, edited by Lauro S. Halstead and Martin Grabois. Following four rather lengthy paragraphs complimenting the book comes a fifth paragraph that I and my constituents hardly believe belongs in a book review section. The reviewer questions whether a physiatrist should perform diagnostic tests such as electromyography, nerve conduction studies, or electrocardiography and suggests that primary care physicians such as the neurologist, the cardiologist, and others should perform the medical care for the rehabilitation patient. This pejorative opinion does not relate to the book but rather seems to be the ruminations of an extraordinarily uninformed observer. The education and training of physiatrists is now a four-year program approved by the Accreditation Committee for Graduate Medical Education and reviewed by the
Pulmonary-function tests
Authors: H. Kazemi
Journal: JAMA (1968)

All physicians, regardless of their types of practice, are seeing more patients with various forms of chronic lung disease. Pulmonary symptoms may be the primary complaint, or they may become apparent during another illness or after an operation. Pulmonary-function tests offer the means of elucidating the type of physiological impairment present, quantitating the degree of malfunction, and allowing for objective follow-up studies in the natural history of the disease and the efficacy of therapeutic measures. Tests of lung function vary from simple measurements of vital capacity to the use of gaseous radioactive isotopes for measurements of regional blood flow, ventilation, and gas exchange. The physician in practice should be able to interpret the results of ventilatory tests and arterial-blood gas analyses, and rely on the pulmonary physiologist and the chest physician for interpretation of the more refined tests of lung function. In this communication, lung-function tests will be reviewed briefly