tbuckley/cabot-search huggingface dataset:
Insulin resistance predicts rapid virological response in non-diabetic, non-cirrhotic genotype 1 HCV patients treated with peginterferon alpha-2b plus ribavirin: A clarification
Authors: Alessandro Grasso
Journal: Journal of Hepatology (2009)

Insulin resistance predicts rapid virological response in non-diabetic, non-cirrhotic genotype 1 HCV patients treated with peginterferon alpha-2b plus ribavirin: Some issuesJournal of HepatologyVol. 52Issue 2PreviewWe read with great interest the report by Grasso et al. in a recent issue of the Journal of Hepatology[1]. They enrolled 90 consecutive, non-diabetic, non-cirrhotic patients with genotype 1 chronic hepatitis C, treated with peginterferon alpha-2b plus ribavirin. Two issues need clarification. Full-Text PDF Open Access We read with interest the comment by Wu and colleagues on our recently published paper [[1]Grasso A. Malfatti F. De Leo P. Martines H. Fabris P. Toscanini F. et al.Insulin resistance predicts rapid virological response in non-diabetic, non-cirrhotic genotype 1 HCV patients treated with peginterferon alpha-2b plus ribavirin.J Hepatol. 2009; 23: 23Google Scholar]. Two issues indeed need to be clarified. The unit of sensitivity of the qualitative reverse-transcription PCR test, Roche Cobas Amplicor assay, was mistakenly reported in the Patients and methods section as copies per millilitre, rather than as international units per millilitre. We apologize for this oversight. Regarding the second issue, although equal variance was found between the two groups (SVR and no-SVR), when the Levene test was applied to HOMA-IR, a Kolmogorov–Smirnov test confirmed a non-normal distribution of HOMA-IR values, as suggested by Wu and colleagues. The Mann–Whitney test, which had actually been applied in our former analysis, failed to demonstrate a significant difference in HOMA-IR between patients with and without SVR, although the p-value was slightly better than the one reported in Table 1. Nevertheless, we agree that this clarification should have been included in the statistical analysis section.
IRRADIATION AND MARROW INFUSION IN ACUTE LEUKEMIA
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
银屑病的生物治疗和癌症风险
Authors: I. Garcia-Doval, M.A. Descalzo, K.J. Mason, A.D. Cohen, A.D. Ormerod, F.J. Gómez-García, S. Cazzaniga, I. Feldhamer, H. Ali, E. Herrera-Acosta, C.E.M. Griffiths, R. Stern, L. Naldi
Journal: British Journal of Dermatology (2018)

银屑病是一种常见的皮肤病,影响全世界高达 3% 的人。银屑病由免疫系统(保护身体免受感染)中的缺陷引起, 导致皮肤过度产生。最严重的银屑病患者需要接受治疗以抑制免疫系统。全身疗法(甲氨蝶呤和环孢素)有助于抑制整个免疫系统,而生物疗法(阿达木单抗、依那西普和优特克单抗)则针对皮肤中的特定免疫通路。然而, 亦存在对这些疗法可能会增加癌症风险的担忧。这项针对爱尔兰、以色列、意大利、西班牙和英国银屑病患者的研究旨在了解花在这些疗法上的时间是否会增加患癌症的风险。将研究期间患癌症的每名患者与性别、年龄、皮肤病中心和进入研究年份均相同的四名无癌银屑病患者(对照)进行比较。计算每位患者在全身和生物治疗上花费的总时间。作者并未发现患癌症的患者和对照患者在全身或生物治疗上花费的时间有所不同。如果考虑先前接触其他全身治疗、银屑病持续时间、吸烟、之前接触光疗和其他同时发生的疾病可能产生的影响,该结果保持不变。该研究表明,在使用生物疗法治疗长达 8 年后,癌症发生的可能性并未增大。
PHYSICAL CAPACITY IN CHILDHOOD
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME FACTORS RELATING TO THE TOXIC ACTION OF ARSPHENAMIN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isabel
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Vitro Comparisons of SENCAR and BALB/c Primary Epidermal Cells
Authors: James E. Strickland, Patton T. Allen, Daniel N. Sauder, Hideki Kawamura, Marian C. Fong, Stuart H. Yuspa
Journal: Environmental Health Perspectives (1986)

Grafting experiments show that the enhanced sensitivity of the SENCAR mouse to skin carcinogenesis by initiation and promotion is a property of the skin itself, suggesting the usefulness of in vitro studies to elucidate the mechanism. Such studies have indicated that cultured epidermal cells of SENCAR mice and the resistant BALB/c strain are remarkably similar in a variety of respects. DNA repair and carcinogen binding are quantitatively similar in cultured cells of SENCAR and more resistant mouse strains. Epidermal Langerhans cell (LC) number and LC-mediated functions were indistinguishable in SENCAR and BALB/c mice. Primary epidermal cells cultured in the presence of various concentrations of 12-O-tetradecanoylphorbol-13-acetate (TPA), retinoic acid, epidermal growth factor (EGF), hydrocortisone, or fluocinolone acetonide failed to reveal differences in growth between BALB/c and SENCAR cells. Cells from these animals bound comparable amounts of EGF with similar kinetics, and the modulation of this binding by TPA and retinoic acid was indistinguishable between strains. Spontaneous expression of infectious, endogenous xenotropic type C RNA virus at very low levels could be demonstrated in primary BALB/c epidermal cells and both BALB/c and SENCAR epidermal lines resistant to Ca2+-induced terminal differentiation. The number of foci of initiated cells after exposure to carcinogens in vivo or in vitro did not differ significantly between SENCAR and BALB/c, suggesting that SENCAR sensitivity is primarily to promotion. However, there are qualitative differences between SENCAR and BALB/c foci. The appearance of foci of cells resistant to terminal differentiation in untreated SENCAR cultures supports the evidence from in vivo studies for the existence of a constitutively initiated cell population in SENCAR mouse skin.
A Critical Analysis of RBRVS
Authors: David M. Ramsey
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The article "A Critical Analysis of the Resource-Based Relative Value Scale" by Dr Maloney<sup>1</sup>is surprising. It attempts to disprove the general perception that procedural medical services are reimbursed at an inappropriately greater rate than cognitive services. However, the way he puts the data together is misleading, the numbers he shows us prove just the opposite of what he says, and there are some disturbing undertones in what he does say. His first deception is the number of hours supposedly worked per week: surgical (87.8) vs medical (70.6). Patient care activities, on-call time, other professional and administrative activities according to Mendenhall<sup>2</sup>actually average: surgical (81.2) vs medical (79.1) for all comers or 81.2 and 74.9, respectively for just the groups included in Maloney's RBRVS critique. That comes to a 6.3-hour difference at the most (very different from the 17 hours he claims), which makes the
Failure
Authors: C. A Pierach
Journal: BMJ (2003)

oncepts of the self and self identity are part of the stock-in-trade of academic philosophy.However, grappling with such ideas is not an element of the day to day work of busy clinicians.The self rarely, if ever, shows up in an undergraduate medical curriculum, except perhaps in psychopathology.This may need to be remedied as we enter the post-genomic age and as clinicians face the advent of "enhancement technologies," many of which are within the scope of
Misspelling of Coauthor Surname
Journal: JAMA Dermatology (2017)

Emanual Maverakis, MD; Elizabeth A. Wang, BS; Kanade Shinkai, MD, PhD; Surakameth Mahasirimongkol, MD, MSc, PhD; David J. Margolis, MD, PhD; Mark Avigan, MD, CM; Wen-Hung Chung, MD, PhD; Jennifer Goldman, MD; Lois La Grenade, MD, MPH; Munir Pirmohamed, PhD, FRCP; Neil H. Shear, MD, FRCPC, FACP; Wichittra Tassaneeyakul, PhD; Wolfram Hoetzenecker, MD, PhD; Jettanong Klaewsongkram, MD; Ticha Rerkpattanapipat, MD; Wiparat Manuyakorn, MD, PhD; Sally Usdin Yasuda, MS, PharmD; Victoria R. Sharon, MD; Andrea Sukhov, BA; Robert Micheletti, MD; Jeff Struewing, MD, MS; Lars E. French, MD; Michelle Y. Cheng, MD
Medically Irreversible Status Asthmaticus in Children
Authors: Lewis R. Beam
Journal: JAMA (1965)

Three children who were moribund because of severe status asthmaticus survived. They were treated by muscle paralysis, endotracheal intubation, and controlled respiration when vigorous medical therapy appeared to have failed. One patient had four such experiences. This method of treatment is indicated only for the purpose of gaining adequate time for medical therapy to become effective. The occurrence of adrenalin fastness in respiratory acidosis, the additive effect of antibiotics on curarization, and the use of sedation warrant caution. The advantages of this method over those of inhalation anesthesia are many.
Interferon-γ inhibits liver regeneration by stimulating major histocompatibility complex class II antigen expression by regenerating liver
Authors: Y Sato
Journal: Hepatology (1993)

The effects of interferon-γ and interleukin-2 on liver regeneration after 70% hepatectomy in rats was studied immunohistologically, with special attention paid to major histocompatibility complex class II antigen expression. Liver regeneration 2 days after partial hepatectomy as assessed on the basis of bromodeoxyuridine labeling index revealed that regeneration was inhibited significantly in rats given a single dose of interleukin-2 or interferon-γ compared with rats that underwent only partial hepatectomy. Simultaneous administration of interleukin-2 and interferon-γ inhibited liver regeneration more markedly than administration of either drug. In rats subjected to partial hepatectomy, Kupffer cells around the portal vein expressed slightly more major histocompatibility complex class II antigen than did sham-operated controls. In the group given interferon-γ, major histocompatibility complex class II antigen expression was markedly increased. Major histocompatibility complex class II antigen expression was greatest in most Kupffer cells of rats given both interleukin-2 and interferon-γ. These results suggest that interferon-γ activates (proliferating) Kupffer cells, in turn leading to suppression of liver regeneration. These major histocompatibility complex class II antigen–positive Kupffer cells act as antigen-presenting cells and present hepatocyte as antigen, the so-called abnormal self, to helper and cytotoxic T cells. Both types of T cells, in turn, may suppress hepatocyte proliferation. The various cytokines induced by the activated Kupffer cells and helper T cells seem to form a network with interferon-γ to regulate liver regeneration. (HEPATOLOGY 1993;18:340–346).
ALCOHOL AND THE HEART
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1938)

TMIECBRITISN cover private use.For example, one-third of £150 rent would usually be less than the private part of such a house would cost to rent.But in the circumstances mentioned a one-third allowance seems clearly inadequate, and we advise our correspondent to claim one-half, and carry his point to personal appeal to the local or Special Com- missioners if necessary.Judging from the inspector's letter he seems to have overlooked two material points: first, that the ground floor is in terms of rent worth more than the others, and, second, that the garage is almost entirely "professional.
THE INFLUENCE OF NEWSPAPERS ON THE HEALTH OF THE COMMUNITY.
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Daydreams of a Doctor.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE "OPEN DOOR" POLICY IN ANIMAL EXPERIMENTATION
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TETANUS FROM ANTI-DIPHTHERIA SERUM.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal