A New Concept of Co-Mutagenicity from a Phenomenon Forgotten for the Past Two Decades: Is It More Important than Previously Expected?
Authors: Takashi Sugimura
Journal: Environmental Health Perspectives (1998)

Research ArticleOpen AccessA new concept of co-mutagenicity from a phenomenon forgotten for the past two decades: is it more important than previously expected? T Sugimura T Sugimura Search for more papers by this author Published:1 November 1998https://doi.org/10.1289/ehp.98106a522Cited by:12AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit "A new concept of co-mutagenicity from a phenomenon forgotten for the past two decades: is it more important than previously expected?." Environmental Health Perspectives, 106(11), pp. A522–A523FiguresReferencesRelatedDetailsCited by Shamovsky I, Ripa L, Börjesson L, Mee C, Nordén B, Hansen P, Hasselgren C, O’Donovan M and Sjö P (2011) Explanation for Main Features of Structure–Genotoxicity Relationships of Aromatic Amines by Theoretical Studies of Their Activation Pathways in CYP1A2, Journal of the American Chemical Society, 10.1021/ja206427u, 133:40, (16168-16185), Online publication date: 12-Oct-2011. Totsuka Y, Nishigaki R, Sugimura T and Wakabayashi K (2006) The possible involvement of mutagenic and carcinogenic heterocyclic amines in human cancer Acrylamide and Other Hazardous Compounds in Heat-Treated Foods, 10.1533/9781845692018.2.296, (296-327), . Oda Y, Totsuka Y, Wakabayashi K, Guengerich F and Shimada T (2006) Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains, Mutagenesis, 10.1093/mutage/gel047, 21:6, (411-416), Online publication date: 1-Nov-2006. SMITH C, QIAN X, ZHA Q and MOLDOVEANU S (2004) Analysis of α- and β-carbolines in mainstream smoke of reference cigarettes by gas chromatography–mass spectrometry, Journal of Chromatography A, 10.1016/S0021-9673(04)01030-1, 1046:1-2, (211-216), Online publication date: 13-Aug-2004. Nishigaki R, Totsuka Y, Takamura-Enya T, Sugimura T and Wakabayashi K (2004) Identification of cytochrome P-450s involved in the formation of APNH from norharman with aniline, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 10.1016/j.mrgentox.2004.05.003, 562:1-2, (19-25), Online publication date: 1-Aug-2004. Totsuka Y, Takamura-Enya T, Nishigaki R, Sugimura T and Wakabayashi K (2004) Mutagens formed from β-carbolines with aromatic amines, Journal of Chromatography B, 10.1016/j.jchromb.2003.10.041, 802:1, (135-141), Online publication date: 1-Mar-2004. Ohe T, Takata T, Maeda Y, Totsuka Y, Hada N, Matsuoka A, Tanaka N and Wakabayashi K (2002) Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 10.1016/S1383-5718(02)00015-3, 515:1-2, (181-188), Online publication date: 1-Mar-2002. Totsuka Y, Kataoka H, Takamura-Enya T, Sugimura T and Wakabayashi K (2002) In vitro and in vivo formation of aminophenylnorharman from norharman and aniline, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/S0027-5107(02)00151-3, 506-507, (49-54), Online publication date: 1-Sep-2002. Hada N, Totsuka Y, Enya T, Tsurumaki K, Nakazawa M, Kawahara N, Murakami Y, Yokoyama Y, Sugimura T and Wakabayashi K (2001) Structures of mutagens produced by the co-mutagen norharman with o- and m-toluidine isomers, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 10.1016/S1383-5718(01)00168-1, 493:1-2, (115-126), Online publication date: 1-Jun-2001. Yim S and Hee S (2001) Bacterial mutagenicity of some tobacco aromatic nitrogen bases and their mixtures, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 10.1016/S1383-5718(01)00152-8, 492:1-2, (13-27), Online publication date: 1-May-2001. Kawamori T, Totsuka Y, Ishihara J, Uchiya N, Sugimura T and Wakabayashi K (2001) Induction of liver preneoplastic lesions by aminophenylnorharman, formed from norharman and aniline, in male F344 rats, Cancer Letters, 10.1016/S0304-3835(00)00679-0, 163:2, (157-161), Online publication date: 1-Feb-2001. Dayem A, Choi H, Kim J and Cho S (2010) Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells, Cancers, 10.3390/cancers2020859, 2:2, (859-884) Vol. 106, No. 11 November 1998Metrics About Article Metrics Publication History Originally published1 November 1998Published in print1 November 1998 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. 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