tbuckley/cabot-search huggingface dataset:
Smoking Cessation
Authors: Jeffrey L Kaufman
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marriages
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Listeriosis outbreak associated with Mexican-style cheese--California
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-Dose Oral Vitamin D Supplementation and Risk of Falls in Older Women
Authors: Daniel Prieto-Alhambra
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Examination of the Urine.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lung, SCLC
Authors: R Cubedo, P Espafia, M Provendo, M Jorge, A Sanchez, Cllnica Puerta, F Vazquez, F Cueva, S Baron, M Candamto, A Calvo, C Ingoyen, R Huidobro, J Casal, C Huidobro, Roy Bremnes', Stein Sundstrom, Ulf Aasebo, I Maestu, J Gomez, J Aparicio, B Montalar, G Munarriz, C Reynes
Journal: Annals of Oncology (1998)
Evaluation and management services in the Resource-Based Relative Value Scale
Authors: P Braun, W C Hsiao, E R Becker, M DeNicola
Journal: JAMA (1988)

Evaluation and management (E/M) services, which include making diagnoses, counseling and educating, developing strategies of care, and following up on treatment, are common to all medical specialties. Surveys of a variety of specialists using the magnitude-estimation method show that physicians agree closely in rating the work of particular E/M services. Regardless of the type of E/M service, the site at which it is performed, or the specialty performing it, work per unit of time varies only slightly. Comparison of work and time for services to which experts assigned billing codes in our consultative process indicates, however, that there may be large differences in the way different specialties use these billing codes. In some instances, work entailed by some of the E/M billing codes within specialties also appears to vary substantially. If empirical studies of physicians' coding and billing practices support our findings, possible responses might include (1) developing specialty-specific resource-based relative values for E/M services and (2) redefining the Physicians' Current Procedural Terminology, edition 4, codes for these services in terms that include time specifications.
TREATMENT OF SYPHILIS BY INHALATIONS OF MERCURIAL VAPOR.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiologically Assessed Collateral Flow and Intracoronary Growth Factor Concentrations in Patients With 1- to 3-Vessel Coronary Artery Disease
Authors: Pier Lambiase, Richard Edwards, Clifford A. Bucknall, Michael S. Marber
Journal: Circulation (2001)

To the Editor:We enjoyed reading the article by Fleisch et al 1 but would like to point out a number of potential factors that detract from the data reported.In particular, we are concerned about the measurement of growth factors and collateral flow index (CFI).As the authors acknowledge, both vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are heparin-binding peptides and, thus, their levels are significantly altered in the presence of heparin.The administration of "nearly identical doses of heparin" does not normalize for heparin's effects, because plasma heparin levels will vary according to the patient's body mass, plasma volume, and age. 2 We have found that after a standard 10 000-unit heparin bolus, both arterial and venous plasma VEGF levels can be undetectable when using using the same enzyme-linked immunoabsorption assay (ELISA) as Fleisch et al, 1 even when there is a 50-fold difference in baseline sample concentrations before heparin administration.This probably explains why one-fifth of the study patients had undetectable VEGF levels.Conversely, arterial bFGF levels are elevated after heparin administration.There is a 3-to 5-fold increase at 30 minutes after heparinization for cardiopulmonary bypass, probably because heparin displaces bFGF from the subendothelial extracellular matrix and luminal surface of blood vessels. 3 Similarly, we have found up to a 10-fold increase in arterial bFGF 5 minutes after the administration of 10 000 units of intravenous heparin before angioplasty.The effects of heparin on VEGF and the variable effect of bFGF displacement from the arterial luminal surface are fundamental confounding factors that were not adequately accounted for in this article.The accurate measurement of CFI is heavily dependant on a correct evaluation of right atrial pressure at the time of balloon inflation.In our experience, if the mean right atrial pressure is assumed to be 5 mm Hg, CFI is overestimated by an average of 30%.This may explain why Fleisch et al 1 used a CFI of 0.3 as the cut off point for sufficient collateral vessel development to protect against ischemia, as opposed to the theoretical and experimentally validated ratio of 0.25. 4Therefore, significant differences exist in the true CFI of the patients studied, which could alter their assignment to the high and low CFI groups.In summary, we question the reliability of the measurements of growth factors and collateral flow and believe that their relationship may be less certain than the authors conclude.
Thrombotic thrombocytopenic purpura. Occurrence two years apart during late pregnancy in two sisters
Authors: W. E. Fuchs
Journal: JAMA (1976)

THROMBOTIC thrombocytopenic purpura (TTP) is an acute, usually fatal syndrome of unknown etiology, characterized by fever, thrombocytopenia, microangiopathic hemolytic anemia, and central nervous system and renal abnormalities. It is more common in women than men, and in 20 reported cases, the onset was during pregnancy.<sup>1</sup>Familial occurrences in siblings<sup>2</sup>and concomitant occurrence in a husband and wife<sup>3</sup>have been reported. The hemolytic-uremic syndrome, which may be clinically identical to TTP, has also been reported to occur in families.<sup>4-6</sup> We report here the occurrence of the classical syndrome of fatal TTP in two sisters (Table). In each sister, the disease began suddenly, near the end of her first pregnancy: one in September 1972, the other in September 1974. eralized weakness in the 36th week of her first pregnancy. Four days later, she experienced transient numbness and paresthesias on the left side <h3>Report of Cases</h3><h3>Case 1.—</h3>
Abstract 180: Defining the metastasome in colorectal cancer: Novel hypotheses on tumor progression, metastasis evolution and therapy by whole genome sequencing
Authors: Heike Allgayer
Journal: Cancer Research (2019)

Abstract Metastasis poses the highest challenge for personalized therapy, partly due to incomplete understanding of its molecular evolution. This work presents the most comprehensive whole-genome study of colorectal metastasis vs. matched primary tumors. The cohort presented supports both early and late dissemination models. 65% of somatic small mutations originated from a common ancestral truncal node, with 15% of small mutations being tumor- and 19% metastasis-specific, implicating a higher mutation rate in metastases. In tumor- and metastasis-specific mutations we observed elevated levels of BRCA-ness signatures. A multistage progression model was confirmed with new components ARHGEF7/ARHGEF33, and ploidy dependent co-occurring SOX9 and HK3 mutations. We found previously undescibed recurrently mutated non-coding elements including specific ncRNAs and 3’ UTRs which will be presented at the meeting, some of them known as potential dual protagonists in metastasis and efferocytosis-/PD-L1 mediated immunosuppression. Furthermore, we discovered genomic aberrations explaining microRNA expression changes during metastasis. Moreover, we found actionable metastasis-specific lesions (which will be reported at the meeting) which would not have been detected in whole genome sequencing of the corresponding primary tumor, suggesting a reconsideration and modifications of current personalized therapy concepts to prevent metastasis. Metastasis-specific small mutations were enriched in PI3K-Akt signaling, cell adhesion, extracellular matrix but also hepatic stellate activation pathway genes, suggesting the initiation of genetic programs for site-specific colonization during metastasis. Taken together, the results presented here reveal novel components of disease progression and metastasis evolution with evidence for metastasis-specific genomic lesions relevant for personalized therapy. Citation Format: Heike Allgayer. Defining the metastasome in colorectal cancer: Novel hypotheses on tumor progression, metastasis evolution and therapy by whole genome sequencing [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 180.
The Script
Authors: Benjamin Brody
Journal: New England Journal of Medicine (2006)

“What happened?” the patient asked. She was coming out of anesthesia after six hours of surgery. A weary resident cleaned dried blood and iodine from the skin around the surgical wound on her abdomen. The anesthesiologist had just removed her breathing tube. The patient, to my surprise, was staring straight at me — the medical student. She asked again: “What happened?”During the previous 6 months, a rapidly expanding abdominal mass had developed. Early in her surgery, a frozen section had been sent to the laboratory, and 20 minutes later a voice over the intercom had confirmed what the surgeons . . .
Cell Systems Erect Barriers to Genetic Change
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome of Chinese patients with chronic myeloid leukaemia (CML) underwent allogeneic bone‐marrow transplantation (BMT)
Authors: C.K. Lee, A.K.W. Lie, R. Liang, W.Y. Au, F.E. Chen, C.S. Chim, Y.L. Kwong
Journal: American Journal of Hematology (1999)

Clinical studies have shown that patients with chronic myeloid leukaemia (CML) treated with allogeneic bone-marrow transplantation (BMT) experience not only prolonged disease-free survival but also complete cure in some. Therefore, we followed a cohort of 81 Chinese patients who received allogeneic BMT. Patients and Methods The donors were either relatives (65 siblings, 1 parent) or unrelated volunteers (15). BMT was performed at a median interval of 11.6 months from diagnosis of CML, and the stages of disease before BMT were: first chronic phase (60 patients), accelerated or second chronic phase in (10 patients), and blastic crisis (11 patients). Three conditioning regimens were employed: Bu-Cy, Cy-TBI, or Bu-Cy-TBI. Standard cyclosporin and short methotrexate protocol were used for acute graft-versus-host disease (GvHD) prophylaxis. Results There were five graft failures with three after related BMT. Patients after related or unrelated BMT had a comparable rate of neutrophil recovery (median = 22 days), but significant delay in platelet recovery occurred after unrelated BMT (median = 34 vs. 20 days, P < 0.05). The latter also had higher incidence of acute GvHD (73% vs. 41%, P < 0.05), although the incidence of chronic GvHD was not different between groups. At a median follow-up of 43.5 months, patients after related BMT had a significantly better rate of disease-free survival (68% vs. 37.3%, P < 0.05) and overall survival (81% vs. 38.9%, P < 0.05) at 4 years. Subgroup analysis of patients after related BMT showed the outcome was better when they were transplanted at first chronic phase. Multivariate analysis showed that advanced disease (RR = 2.01, 95% CI = 1.48–2.73) significantly worsened the outcome of BMT, whereas the presence of chronic GvHD had a protective effect against relapse and survival (RR = 0.09, 95% CI = 0.02–0.38). Conclusion Allogeneic BMT is a curative form of treatment for patients with CML. Treatment outcome is best for those who undergo transplants from HLA-matched siblings during the first chronic phase. Am. J. Hematol. 61:85–89, 1999. © 1999 Wiley-Liss, Inc.
Who Likes the New Drug Regulations?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laparotomy
Authors: A V Pollock
Journal: Journal of the Royal Society of Medicine (1981)

In a consecutive series of 1207 major laparotomies, the incidence of wound infections, wound failures and chest complications was prospectively recorded; this allowed certain predisposing factors to be identified, both avoidable and unavoidable. Among the former were operative bacterial contamination, haemorrhagic and septic shock and the use of nasogastric tubes; the most important of the latter were male sex and pre-existing bronchitis.
Allogeneic Hematopoietic Cell Transplantation in Elderly Patients Aged 65 and Older: A Retrospective Analysis By the Complications and Quality of Life Working Party of the EBMT
Authors: Grzegorz W. Basak, Isabel Sánchez-Ortega, Eric Beohou, Steffie van der Werf, Myriam Labopin, Anja van Biezen, Peter Dreger, Silvia Montoto, Carlo DuFour, Nicolaus Kroger, Arnon Nagler, Gerhard Ehninger, Dietger Niederwieser, Jurgen Finke, Dietrich W. Beelen, Lothar Kanz, Johanna Tischer, Gernot Stuhler, Ghulam J Mufti, Bertram Glass, Renate Arnold, Anna Sureda, Mohamad Mohty, Tapani Ruutu, Rafael F. Duarte
Journal: Blood (2016)
Results of in Vivo and in Vitro Studies for Assessing Prenatal Toxicity
Authors: Diether Neubert, Gudrun Blankenburg, Ibrahim Chahoud, Gabriele Franz, Rainer Herken, Michael Kastner, Stephan Klug, Joachim Kroger, Ralf Krowke, Constanze Lewandowski, Hans-Joachim Merker, Thomas Schulz, Ralf Stahlmann
Journal: Environmental Health Perspectives (1986)

Examples of a combined approach using in vivo as well as in vitro methods for the assessment of prenatal toxicity are presented. The topics discussed include the analysis of the possible embryotoxic potential of valproic acid (VPA), female sex hormones, bis(tri-n-butyltin) oxide (TBTO), and acyclovir and the problem of supplementing in vitro systems with drug-metabolizing activity.