tbuckley/cabot-search huggingface dataset:
"THE CHRONIC ABDOMEN"
Journal: JAMA (1923)

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Medical History
Authors: Marjorie C. Meehan
Journal: JAMA (1972)

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Epidemiology of Toluene Diisocyanate (TDI)-Induced Respiratory Disease
Authors: John M. Peters, David H. Wegman
Journal: Environmental Health Perspectives (1975)

This paper describes our experience with the respiratory effects of TDI. Five respiratory reactions attributable to TDI are described with supporting evidence. The reactions are sensitization, irritation from overexposure, acute loss of ventilatory capacity, accelerated loss of pulmonary function and induction of a general asthmatic state. Evidence is presented that suggests a safe exposure level.
Blue mood, blackened lungs. Depression and smoking
Authors: R. M. Glass
Journal: JAMA (1990)

The notion of "self-medication" is one of the most intuitively appealing theories about drug abuse. According to this hypothesis,<sup>1</sup>drug abuse begins as a partially successful attempt to assuage painful feelings. This does not mean seeking "pleasure" from the use of drugs. Rather, individuals predisposed by biological or psychological vulnerabilities find that drug effects corresponding to their particular problems are powerfully reinforcing. For example, clinical observations suggest that persons who have difficulty regulating mood may be particularly vulnerable to abuse of cocaine or other stimulant drugs, persons who have difficulty controlling anger to abuse of heroin and other opioids, and persons who have high anxiety levels to abuse of alcohol and other sedatives. Many drug abusers report that their drug helped them to feel "normal," even before they developed physiological dependence with continued drug use necessary to prevent withdrawal symptoms.<sup>1</sup> Such clinical observations are supported by the recent
EXPERIMENTAL WORK ON CAUSATION OF LETHARGIC ENCEPHALITIS
Journal: JAMA (1920)

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Supplemental Oxygen and Risk of Surgical Site Infection
Authors: Ozan Akça, Daniel I Sessler
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Original Investigations.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICINE AT SALERNO
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhancing autophagy improves and slows the progression of non-alcoholic steatohepatitis disease
Authors: Maria Ruart, Nuria Suárez-Herrera, Genís Campreciós, Carla Montironi, Celia Martínez Sánchez, Erica Lafoz, Héctor García-Calderó, Tiago Da Silva Ramos, Marina Vilaseca Barceló, Anna Oncins, Pol Olivas, Mar Coll, Isabel Graupera, Scott Friedman, Juan Carlos Garcia Pagan, Virginia Hernandez-Gea
Journal: Journal of Hepatology (2020)
Eruptive pseudoangiomatosis
Authors: I. Neri, A. Patrizi, V. Guerrini, G. Ricci, R. Cevenini
Journal: British Journal of Dermatology (2000)

Eruptive pseudoangiomatosis (EPA) is a rare, benign, spontaneously regressing childhood exanthem. The term was recently coined by Prose et al. 1 to describe a dermatosis characterized by the sudden onset of a few to several bright red angioma-like papules with a different histopathology from the true angiomas. We describe three patients with the typical lesions of EPA but with some peculiar features not previously described. We discuss the suspected viral aetiology of EPA, and hypothesize a multifactorial aetiopathogenesis.
Trends in serum cholesterol levels among US adults aged 20 to 74 years. Data from the National Health and Nutrition Examination Surveys, 1960 to 1980. National Center for Health Statistics-National Heart, Lung, and Blood Institute Collaborative Lipid Group
Journal: JAMA (1987)

From 1960 to 1980, serum cholesterol levels were determined for three different national surveys of the US noninstitutionalized population aged 20 to 74 years conducted by the National Center for Health Statistics, Hyattsville, Md. Serum cholesterol determinations for each of the three surveys were standardized to the Abell-Kendall laboratory method. Age-adjusted mean serum cholesterol levels decreased by 6 to 8 mg/dL (0.16 to 0.21 mmol/L), or 3% to 4%, between the 1960 to 1962 and the 1976 to 1980 surveys. For men, this represented a decrease from 217 mg/dL (5.61 mmol/L) to 211 mg/dL (5.46 mmol/L) and for women, a decrease from 223 mg/dL (5.77 mmol/L) to 215 mg/dL (5.56 mmol/L). Both declines were statistically significant. Mean serum cholesterol level decreased significantly in whites but not in blacks, and in all education subgroups for whites except men with less than nine years of education. In addition, the percentage of men and women with high-risk and moderate-risk cholesterol levels decreased during this period.
WITH PREJUDICE
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospitals Report Increase In Gram-Negative Infections
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ADA News and Meetings
Authors: Daniel Freeman, Anton-Lewis Usaia, Donald Austin, Bork Balkan, Joyce Barnett, Larry Barsamian, Rohnert Park, James Beard, Mark Beerken, Lori Boerger, Santa Cruz, Geduljn Bronislava, San Diego, John Brosnan, S John's, Brenda Broussard, Carol Carrick, Joan Chidsey, Lan Ching, David Clemmons, Sylvie Cloutier, Sheila Curry, Jeanne Dahl, Clifton Park, Ny Dailey, Mark Davids, F Davis, British Columbia, Richard Canada, E Santis, Bel Air, Diane Demain, Cynthia Draper, Shirley Dubell, Santa Rosa, Glenn Dunlap, Ossama El-Kabbani, Katharine Erfle, Colleen Faddick, Kathleen French, J Fulwyler, Santa Ana, Julie Grim, S Habbu, Jonathan Hauptman, Margie Hendrick, Walla Walla, A Henry, Mark Johnston, San Antonio, T Eilene, Marie Jones, Patrick Klein, Grover City, Lynn Kowalski, Joaquin Kuyeng, Ami Laws, Menlo Park, Cathy Lloyd, Edvarda Lyons, William Mann, Donald Mcmillan, Pablo Mora-Mora, Dorris Dallas, Patricia Mott, Mike Paul, Lorraine Muekkler, Brooke Musgrove, Alberta Alta, Leena Canada, Lisa Mykkanen, E Newman, Carol York, John Olson, Los Ong, David Angeles, Peggy Owerbach, Judith Parisot, Robert Petrowitz, Thorkuil Ploug, Christopher Randolph, Michael Roden, Stephen Savoia, Christine Scanlon, Helen Seifert, Leslie Silverman, Kathryn Simpkins, Richard Snyder, Jane Stewart, J Stringer, Nicholas Taweel, Pa Wagner, Elizabeth Warren-Boulton, Susan Wheeler, Carol Woodward, Lawrence Young
Journal: Diabetes Care (1992)
Myocardial Infarction Associated With Antihypertensive Drug Therapy-Reply
Authors: Julie E. Buring
Journal: JAMA (1996)

<h3>In Reply.</h3> —Dr Blandino has suggested that "miscommunication" of nondefinitive data disparaged the use of diuretics initially. Nobody would disagree that reliable evidence of net benefits of drug treatment of mild to moderate hypertension on subsequent cardiovascular mortality, stroke, and myocardial infarction were derived from randomized trials primarily testing diuretics and β-blockers.<sup>1-3</sup>However, the stroke benefit is virtually identical to that predicted from meta-analysis of observational studies, whereas for myocardial infarction the benefit is about one-half to two-thirds that predicted. Both chance and a delayed effect on atherogenesis may explain this shortfall, but another plausible hypothesis is possible elevations of low-density lipoprotein cholesterol by about 5%, which could increase risk of myocardial infarction by 15%. Thus, randomized trial data are needed to provide reliable evidence on the balance of risks and benefits of all these agents. Dr Blandino and Drs Cooper and Freeman question the degree of clinical certainty
Somnos.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The risk of contracting HIV infection in the course of health care
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Liver
Authors: Frederick W. Bauer
Journal: JAMA (1973)

The first percutaneous needle biopsies of the human liver were performed in Italy more than 75 years ago. Almost 50 years passed before those first halting steps led to battalions of investigators advancing confidently on man's largest organ which, fortunately, possesses great regenerative powers. The result has been an accumulation of an enormous amount of research, speculation, and literature addressed to liver disorders. An improved understanding of both disease in general and liver disease in particular has resulted from much of this activity, especially from that correlating epidemiologic and clinical information with the findings of the anatomic and clinical laboratory. Of the many volumes written about liver disorders during the past 15 years, this is the first sponsored by the International Academy of Pathology. Thus, this volume reflects the strong histopathologic orientation of its sponsor; the limited discussion of the clinically useful contributions from immunology, serology, and biochemistry may disappoint
A phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of idelalisib in combination with rituximab for previously treated indolent non-Hodgkin lymphomas (iNHL).
Authors: Gilles A. Salles, Thomas J. Ervin, Robert Dichmann, Rod Ramchandren, Ray D. Page, Ramakrishna Battini, William E. Lawler, Leanne Holes, Adeboye H. Adewoye, Sven De Vos
Journal: Journal of Clinical Oncology (2014)

TPS8620 Background: PI3Kδ is critical for activation, proliferation and survival of B cells and plays a role in homing and retention in lymphoid tissues. PI3Kδ signaling is hyperactive in many B-cell malignancies. Idelalisib (GS-1101) is a first-in-class, targeted, highly selective, oral inhibitor of PI3Kδ that reduces proliferation, enhances apoptosis, and inhibits homing and retention of malignant B cells in lymphoid tissues (Lannutti et al, 2011). A phase 2 trial demonstrated that idelalisib is highly active in pts with heavily pretreated iNHL: response rate was 57% (6% CR) and median PFS was 11 mos with an acceptable safety profile (Gopal et al, 2014). Methods: A planned 375 pts with previously treated recurrent iNHL, who have measurable lymphadenopathy, have received prior anti-CD20-antibody-containing therapy, and who have iNHL that is not refractory to rituximab (R) will be randomized in a 2:1 ratio into Arm A or Arm B of the study. In Arm A, subjects will receive idelalisib at 150 mg BID continuously + R at 375 mg/m2 (weekly x 4 then every 8 weeks x 4). In Arm B, subjects will receive placebo BID instead of idelalisib. Stratification factors include tumor type (follicular lymphoma vs others), tumor burden (high vs low), and time since completion of last prior therapy for iNHL (<18 months vs ≥18 months). The primary endpoint is PFS and secondary endpoints include ORR, lymph node response rate, CR rate, and OS. This is an event-driven trial and primary endpoint evaluation will be based on independent central review. For the primary efficacy analysis, the difference in PFS between the treatment arms will be assessed in the ITT analysis set using Kaplan-Meier methods and the stratified log-rank test. The study opened for enrollment in Dec 2012. Clinical trial information: NCT01732913.