tbuckley/cabot-search huggingface dataset:
Blood volume changes following closure of intracardiac left-to-right shunts
Authors: A. B. Gazzaniga
Journal: JAMA (1966)

Total blood volume was measured by means of iodinated I<sup>131</sup>serum albumin and a semiautomatic instrument (Volemetron) in seven male patients with atrial septal defects and seven male patients with ventricular septal defects. All 14 patients underwent open repair of their cardiac lesion. Measurements were made preoperatively, 12 to 14 days postoperatively, and eight to ten weeks postoperatively. In the atrial septal defect group there was a 10% decrease in total blood volume eight to ten weeks postoperatively. In the ventricular septal defect group there was a 9% decrease in total blood volume eight to ten weeks postoperatively. Both plasma and red blood cell volume were significantly reduced in the former group. In the latter group the only significant reduction was in plasma, although six of the seven patients had a small reduction in red blood cell volume.
Cancer statistics
Authors: L. Kinlen, M. Vessey
Journal: BMJ (1976)

<h3>Objectives</h3> To investigate the mortality and cancer incidence of female firefighters, a group where there are limited published findings. <h3>Methods</h3> Participating fire agencies supplied records of individual firefighters including the number and type of incidents attended. The cohort was linked to the Australian National Death Index and Australian Cancer Database. Standardised mortality ratios and standardised cancer incidence ratios were calculated separately for paid and volunteer firefighters. Volunteer firefighters were grouped into tertiles by the duration of service and by a number of incidents attended and relative mortality ratios and relative incidence ratios calculated. <h3>Results</h3> For volunteer firefighters (n=37 962), the overall risk of mortality and risk from all major causes of death were reduced when compared with the general population whether or not they had ever attended incidents. Volunteer firefighters had a similar cancer incidence when compared with the general population for most major cancer categories. Female volunteer firefighters have usually attended few fires. Of those who had turned out to incidents, only one-third had attended more than 12 fires about half the number for male volunteers. Mortality and cancer incidence for paid female firefighters (n=1682) were similar to the general population but the numbers were small and so power was limited. <h3>Conclusions</h3> Female volunteer firefighters have a cancer incidence similar to the general population but a reduced risk of mortality which is likely to be a result of a ‘healthy volunteer’ effect. Most of the paid female firefighters were relatively recent recruits and it will be important to monitor the health of this group as more women are recruited to front-line firefighting roles.
p53, Cip1, and Gadd153 Expression Following Treatment of A549 Cells with Natural and Man-Made Vitreous Fibers
Authors: Neil F. Johnson, Richard J. Jaramillo
Journal: Environmental Health Perspectives (1997)

DNA damage induced by chemicals and ionizing radiation is associated with the expression of negative regulators of the cell cycle.The arrest of cells in Gl and G2 phases of the cell cycle provides time for DNA repair.Asbestos fibers are carcinogenic when inhaled by both humans and animals; however, the mechanism by which the fibers exert their effect is unknown.This work was undertaken to determine whether the expression of DNA damage-inducible genes differs between crocidolite, a fiber positive for lung tumors, and JM 100 glass microfiber, which is negative for lung tumors when inhaled by rats.Temporal and dose-related expressions of p53, Cipl, and Gadd153 proteins were determined in cultured A549 cells treated with either Union Internationale Contre le Cancer crocidolite or JM 100 for 20 hr and cultured in fresh media.Immunolabeled cells were analyzed by flow cytometry, and the increased number of proteinexpressing cells was determined by subtracting the expression in unexposed cells from exposed cells.Crocidolite induced the expression of all three proteins with a maximum expression after approximately 18 hr in fresh media.At a similar time point, JM 100 did not markedly induce the three proteins.Crocidolite also induced a dose-dependent increase in the number of cells in the G2 phase of the cell cycle.These results show that asbestos behaves like ionizing radiation and genotoxic chemicals by inducing proteins associated with DNA damage and cell-cycle arrest.The clear difference in response between crocidolite and JM 100 may help elucidate the mechanism of action of toxic and nontoxic fibers.
Graduate Medical Education in the United States
Authors: A. E. Crowley
Journal: JAMA (1982)

<h3>Methodology</h3> Information on graduate medical education is collected by means of an annual survey of residency programs and participating institutions. The 1981 survey was conducted in fall 1981 in preparation for an early spring publication of the directory. By Feb 1, 1982, more than 96% of accredited residency programs had responded, providing statistics on the number of residents on duty by year of training by type of medical school (ie, US or Canadian school, foreign school, or osteopathic school), sex, and citizenship. The data on enrollment and graduates of US schools have been obtained from the annual Liaison Committee on Medical Education (LCME) survey of US medical schools. The response rate in this survey has been 100% for the past ten years. The data on residency programs and residents have been tainedfrom the annual survey of residency programs. The response rate has been 94% to 96% for the
Journal of Korean Medical Association, Seoul
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Gentamycin"!
Authors: DIETER W. GUMP
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 March 1972"Gentamycin"!DIETER W. GUMP, M.D.DIETER W. GUMP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-3-514_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a demonstration of editorial schizophrenia you have spelled the antibiotic gentamicin correctly in the article "Combined Use of Gentamicin and Carbenicillin" (Ann Intern Med 75:925-927, 1971) and incorrectly in another article, "Severe Pneumonia in Renal Transplant Patients" (Ann Intern Med 75:887-894, 1971) appearing in the same issue. In the latter article it is repeatedly spelled "gentamycin," which is clearly incorrect.Although gentamicin was originally spelled with a "y" in the older literature, the AMA committee on generic names decided on the current spelling because gentamicin does not come from the genusStreptomycesbut from the genus...Reference1. WEINSTEIN M: International symposium on gentamicin—a new aminoglycoside antibiotic. J Infect Dis 119:533-534, 1969 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine College of Medicine The University of Vermont Burlington, Vt. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1972Volume 76, Issue 3Page: 514-514KeywordsAntibioticsPneumoniaRenal transplantationSchizophrenia Issue Published: 1 March 1972 PDF downloadLoading ...
What the educators are saying
Authors: Val Wass
Journal: BMJ (2004)

Training based on competency outcomes has flourished in both undergraduate and postgraduate education, in a climate of increasing accountability to the NHS. But there is scant evidence to support this arguably minimalist and behaviourist approach to clinical learning. Two recent papers use educational theory to propose that competency is not the same as competence. They propose that competency depends on learning through experience in the workplace and is at risk from the modern “sign off as soon as you can do it” approach. Worth a read if you too are concerned by current trends. Medical Education 2004;38: 587-92, 593-8 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] A longitudinal qualitative study from a London medical school highlights the difficulties that medical students face when they start training on the wards. It says that although students are motivated to learn through patient contact, some aspects of the hospital environment are unhelpful. Students felt that they didn't have a genuine clinical role and were undervalued as … [1]: {openurl}?query=rft.jtitle%253DMedical%2Beducation%26rft.stitle%253DMed%2BEduc%26rft.aulast%253DTalbot%26rft.auinit1%253DM.%26rft.volume%253D38%26rft.issue%253D6%26rft.spage%253D587%26rft.epage%253D592%26rft.atitle%253DMonkey%2Bsee%252C%2Bmonkey%2Bdo%253A%2Ba%2Bcritique%2Bof%2Bthe%2Bcompetency%2Bmodel%2Bin%2Bgraduate%2Bmedical%2Beducation.%26rft_id%253Dinfo%253Adoi%252F10.1046%252Fj.1365-2923.2004.01794.x%26rft_id%253Dinfo%253Apmid%252F15189254%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1046/j.1365-2923.2004.01794.x&link_type=DOI [3]: /lookup/external-ref?access_num=15189254&link_type=MED&atom=%2Fbmj%2F329%2F7461%2F335.atom [4]: /lookup/external-ref?access_num=000221738200004&link_type=ISI
The bicentennial of the New York Hospital (1771-1971)
Authors: E. H. Luckey
Journal: JAMA (1971)

Institutions,, have character and personality. And like people these characteristics are the result of their origins, those who have influenced their lives, and their experiences. The New York Hospital, for one, was conceived as, and remains, a public institutional resource in health. From its inception it has had both public and private support. It is sometimes difficult to imagine the time of its origins, 200 years ago. New York City was a small metropolis with 30,000 people on May 16, 1769, when the young Dr. Samuel Bard gave his inaugural address at Trinity Church to the two medical graduates of King's College. He, at age 28, had been influential in the establishment of the King's College curriculum for medical studies, and, most fortunately, was given the privilege of greeting the first two bachelors of medicine on their graduation. His pleas and admonitions, which are set down in his paper, "A
Combining Methotrexate with Prednisone To Treat Temporal Arteritis
Journal: Annals of Internal Medicine (2001)

Summaries for Patients16 January 2001Combining Methotrexate with Prednisone To Treat Temporal ArteritisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-2-200101160-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Giant-cell arteritis (also called temporal arteritis) involves inflammation of large and medium-sized arteries (vasculitis). This condition occurs in elderly people and can lead to sudden blindness when the inflammation involves the temporal artery, an artery located on the side of the head that supplies blood to the eye. Prompt treatment can prevent blindness. Standard therapy for giant-cell arteritis consists of large doses of the drug prednisone, followed by a gradual decrease in the dose. Patients need to take a low dose of prednisone for an average of 2 ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Combined Treatment of Giant-Cell Arteritis with Methotrexate and Prednisone. A Randomized, Double-Blind, Placebo-Controlled Trial.” It is in the 16 January 2001 issue of Annals of Internal Medicine (volume 134, pages 106-114). The authors are JA Jover, C Hernández-García, IC Morado, E Vargas, A Bañares, and B Fernández-Gutiérrez.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCombined Treatment of Giant-Cell Arteritis with Methotrexate and Prednisone Juan A. Jover , César Hernández-García , Inmaculada C. Morado , Emilio Vargas , Antonio Bañares , and Benjamín Fernández-Gutiérrez Metrics 16 January 2001Volume 134, Issue 2Page: I-71KeywordsArteriesBlindnessHeadachesImmune systemInflammationMethotrexatePatientsTemporal arteritisVasculitisVision ePublished: 16 January 2001 Issue Published: 16 January 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Leadership Program Award Winners
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parroting Lymphoma
Authors: Jordan D. Anderson, Vincent T. Ho, Kyle T. Wright, Bruce D. Levy, Joseph Loscalzo
Journal: New England Journal of Medicine (2020)

A 48-year-old man presented with a 3-day history of low-grade fevers and dull, frontal headache pain, which he rated at 5 on a scale of 0 to 10, with 10 indicating the most severe pain. He also noted myalgias, malaise, and chills.
Hyperthermia potentiates doxorubicin-related cardiotoxic effects
Authors: Y. D. Kim
Journal: JAMA (1979)

The intercurrent administration of doxorubicin hydrochloride to a patient undergoing whole-body hyperthermia for the treatment of metastatic cancer repeatedly produced ventricular irritability and cardiac dysfunction. Individually, doxorubicin and hyperthermia were tolerated by the patient without incident. Catecholamine determinations showed that the administration of doxorubicin under hyperthermic conditions increased the liberation of both epinephrine and norepinephrine. The acute synergistic cardiotoxic effects occurred with doxorubicin dosages that were severalfold less than those associated with only mild and transient ECG disturbances under normothermic conditions. (<i>JAMA</i>241:1816-1817, 1979)
Genome-Wide Association Study Identifies Germline Polymorphisms Associated with Relapse of Childhood Acute Lymphoblastic Leukemia
Authors: Jun J. Yang, Cheng Cheng, Devidas Meenakshi, Xueyuan Cao, Dario Campana, Wenjian Yang, Yiping Fan, Geoffrey A.M. Neale, Nancy Cox, Paul Scheet, Michael J. Borowitz, Naomi Winick, Paul L. Martin, W. Paul Bowman, Bruce Camitta, Gregory Reaman, William L. Carroll, Cheryl L Willman, Stephen P. Hunger, William E. Evans, Ching-Hon Pui, Mignon L. Loh, Mary V. Relling
Journal: Blood (2012)
Assessing 2-month clinical prognosis in patients with solid tumors: Final results of PRONOPALL study.
Authors: Hugues Pierre Bourgeois, Philippe Solal-Celigny, Olivier Capitain, Emmanuelle Bourbouloux, Julien Baudon, Marie Marcq, Eveline Boucher, Valérie Delecroix, Emmanuel Blot, MARC Ferec, Joelle Egreteau, Xavier Artignan, Stephane Corbinais, Corinne Alleaume, Oana Cojocarasu, Anne-Claire Hardy-Bessard, Emmanuel Naudeix, Virginie Berger, Pierre Ingrand, Francoise Grude
Journal: Journal of Clinical Oncology (2014)

9558 Background: In 2008, results about a prognostic score defined by 4 factors (Karnofsky index PS, number of metastatic sites, serum albumin and LDH levels) in a population of 177 hospitalized patients in two hospitals were published (Barbot et al, 2008). Albumin threshold is 33 g/L and LDH one is 600 IU/L. The scoring allowed to define 3 different patient populations: A : low score (0 to 3), B: intermediate score (4 to 7) and C : high score (8 to 10). The survival rates at 2 months were 92.2% ± 3.8 (population A), 42.7% ± 5.2 (population B) and 8.3% ± 4.6 (population C). Methods: in order to validate this score, we decided to start a multicentric trial with a high proportion of out-patients. Results: between October 2009 and October 2010, 302 patients were included from 16 institutions. Inclusion criteria: adult patients with a solid tumor in a palliative setting with one or more of the three following criteria: life expectancy of less than 6 months, PS ≥ 2, evidence of disease progression during palliative chemotherapy. All patients signed an informed consent form. 265 (88%) patients were evaluable for the first analysis. 37 patients were not eligible. Median age: 66 years [37-88], women 59%, men 41%. PS 0-1 (45%), PS 2 (37%), PS 3-4 (18%). The most frequent primary sites: breast (29%), colon/rectum (28%), lung (13%), ovary (11%), pancreas (11%), other (8%). One metastatic site (32%), two (35%), more than two (31%). Median LDH level was 397 IU/L [118-4314]. Median level of serum albumin was 35 g/L [13-54]. According to the prognostic score, the 2-month survival rate was 92% and the median survival rate was 301 days [209-348] (population A, 131 patients), 64% and 78 days respectively [71-113] (population B, 113 patients) and 24% and 35 days respectively [14-56] (population C, 21 patients). These three populations are statistically different (p<0.0001). Among the 4 factors, only PS, LDH and serum albumin were statistically connected to survival rate (p<0.0001). 63 patients, aged 75 years and older, allowed to validate the prognostic score for oncogeriartric patients too (p=0.0002). Conclusions: PRONOPALL confirms the three prognostic profiles defined by the combination of these four factors and is useful in daily practice. Clinical trial information: 2009-A00936-51.
EPIDEMIC VIRUS CONJUNCTIVITIS
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General Practice
Authors: Jo Ann Rosenfeld
Journal: JAMA (1995)

This general textbook of primary care medicine is an ambitious tome by a single author, John Murtagh, MD, MBBS, who is a professor of general practice, medical editor of<i>Australian Family Physician</i>, head of the Department of Community Medicine at Box Hill Hospital, and a long-time practitioner. The book was written with "the recent graduate and medical student in mind" as a comprehensive text of Australian medical practice focusing on "the very basics of medical principles and management." It is overwhelmingly broad and immeasurably deep in experience-based knowledge and manages quite well to accomplish its primary mission. The book is organized very interestingly into sections that are general, symptom based, and founded on topics of common interest, such as children's health, women's health, or men's health (an unusual title!). After an interesting section on the basis of general practice, which discusses subjects as varied as nonverbal communication and body language,