tbuckley/cabot-search huggingface dataset:
Attack on liver cancer.
Journal: BMJ (1966)

MDICALJOUN.ing," " 2 and although patients vary considerably in their response" it does not often produce postural or exertional hypotension.But in perhaps one patient in five or six, particularly those with rather high blood-pressure,'2 methyl- dopa does not provide adequate control.Some patients become tolerant to the drug.The frequency of this varies in different reports,'9 but it is less of a problem than with ganglion-blocking drugs or guanethidine.Most patients given methyldopa experience some unwanted effects,'7 19 but the commonest of these, drowsiness, usually lasts only a few days.Other frequent unwanted effects24 are dryness of the mouth and inversion of sleep rhythm.Less common but more important are several shared with other hypotensive drugs; these include depression, stuffy nose, troublesome diarrhoea, and fluid retention, which may be serious if heart failure is precipitated.'Fever and occasion- ally altered responses to tests of liver function are rare but serious toxic effects.In most recorded series treatment with methyldopa has had to be discontinued in perhaps one-third of patients either because of failure to control the blood- pressure or because of unwanted effects.In the remainder reasonable control of pressure has been achieved.Methyldopa's principal advantages are thus its control of blood-pressure in both lying and standing positions, freedom from postural and exertional swings in pressure, which often make treatment with guanethidine difficult, and the fact that exact dosage appears to be less critical than with other drugs." Its main disadvantages are its failure to control blood-pressure in some patients, the high frequency of unwanted effects, however mild some may be, and the large number of tablets needed-up to nine or twelve a day for some patients.This could presumably be remedied by the production of a 500-mg.tablet in addition to the present one of 250 mg.There would seem few contraindications to the use of the drug, though it is not the first choice in malignant hypertension and probably should not be given to patients with a previous history of depression.Its use in combina- tion with other drugs requires further study, though thiazide diuretics certainly potentiate its action,'2 and may also be needed to control fluid retention.'2The main problem is to decide whether treatment is needed at all.Certainly there are still too many patients with high blood-pressure, most of them elderly, who suffer more from their treatment than they would from the untreated disease.
Architectural Designs for a Small Hospital. A Selection From the Designs Submitted in a Contest Conducted by The Modern Hospital for Plans of a Thirty to Forty Bed Hospital—Including Designs Receiving Prizes and Honorable Mention—with Critical Comments of the Plans and with Special Reports on the Organization and Equipment of the First Prize Hospital.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poliomyelitis: A Handbook for Physicians and Medical Students Based on a Study of the 1931 Epidemic in New York City
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessing the Cancer Risk from Environmental PCBs
Authors: Vincent James Cogliano
Journal: Environmental Health Perspectives (1998)

A new approach to assessing the cancer risk from environmental polychlorinated biphenyls (PCBs) considers both toxicity and environmental processes to make distinctions among environmental mixtures. New toxicity information from a 1996 cancer study of four commercial mixtures strengthens the case that all PCB mixtures can cause cancer, although different mixtures have different potencies. Environmental processes alter PCB mixtures through partitioning, chemical transformation, and preferential bioaccumulation; these processes can increase or decrease toxicity considerably. Bioaccumulated PCBs are of greatest concern because they appear to be more toxic than commercial PCBs and more persistent in the body. The new approach uses toxicity studies of commercial mixtures to develop a range of cancer potency estimates and then considers the effect of environmental processes to choose appropriate values for representative classes of environmental mixtures. Guidance is given for assessing risks from different exposure pathways, less-than-lifetime and early-life exposures, and mixtures containing dioxinlike compounds.
Physical Medicine
Authors: Arthur L. Watkins
Journal: New England Journal of Medicine (1947)

DURING the war rapid developments occurred in the field of physical medicine. Activities included in this specialty have expanded to comprise more active and diversified treatment during convalescent stages of disease to ensure a speedy return of injured soldiers to combat or workmen to industry. In addition to widening, the field is also reaching greater depths through the establishment of research programs to investigate some of the fundamental problems of the effects of physical agents. Along with these advances it has become apparent that it is necessary for men to receive special training in physical medicine to understand properly the . . .
British Journal of Radiology, London
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ptomaines
Authors: T. Stevenson
Journal: BMJ (1884)

THE following are the chief peculiarities of the cephalotribe I show you.1.It is longer than those in use, being fifteen inches, of which the blades are ten, and the handles five ; therefore, it is better adapted for operations at or above the pelvic brim.Each blade and handle is measured from the lock respeetively.2. In breadth of blade and pelvic eurve, this cephalotribe is similar to Barnes's long forceps, an instrument I have used' upwards of 600 times in 4,000 deliveries.I have, therefore, modelled my cephalotribe on the lines of a forceps whose efficiency I have fully proved.Further, as I believe axis-traction depends more on the accoucheur thpn on his tool, I discard all useless encumbrances, such as traction-rods, with the accompanying belly-band or waist-belt.3. The cephalotribe possesses, also, a yery moderate cephalic curve.This facilitates introduction, and, combined with the pelvic curve, renders slipping less likely when the. liad occ'upies a very anterior position above the pubes.Here, straight cephalotribes fail.4. This cephalotribe is much less foriWdable and more efficient than those of Hicks and Kidd, etc., and can be applied in the same manner and with as great facility as the ordina~ry obstetric forceps.The ser- vices of an assistat are optional.5. When the screw is applied to its utmnositlimit, the space occupied by the blades is one inch and a half.6.The shoulders, In' addition to affording gtea htati~ctle power,
Whole Exome Sequencing Identifies Novel MPL and JAK2 M utations in Triple Negative Myeloproliferative Neoplasms
Authors: Jelena D Milosevic Feenstra, Harini Nivarthi, Heinz Gisslinger, Emilie Leroy, Elisa Rumi, Ilyas Chachoua, Klaudia Bagienski, Blanka Kubesova, Daniela Pietra, Bettina Gisslinger, Roland Jäger, Doris Chen, Tiina Berg, Martin Schalling, Michael Schuster, Christoph Bock, Stefan N. Constantinescu, Mario Cazzola, Robert Kralovics
Journal: Blood (2015)
Fatal Encephalitis Apparently due to Rabies
Authors: Jacques Devriendt
Journal: JAMA (1982)

We describe a case of fatal encephalitis apparently due to rabies despite treatment with human diploid cell vaccine from the day of exposure but without rabies immune globulin (or serum). This case reinforces the need for rabies immune globulin as part of rabies treatment. (<i>JAMA</i>1982;248:2304-2306)
Serum creatine kinase screening for susceptibility to malignant hyperthermia
Authors: E. H. Flewellen
Journal: JAMA (1986)

<h3>In Reply.—</h3> The mechanism of MH that was proposed in the MEDICAL NEWS &amp; PERSPECTIVES article is the one commonly cited in the literature<sup>1,2</sup>and in anesthesiology textbooks.<sup>3,4</sup>It is the product of the research of several investigators who have worked with colonies of pigs in which the MH syndrome includes muscle rigidity. This porcine syndrome more closely parallels the clinical course of the disease than does the syndrome evidenced in Dr Williams' pig colony.
Carcinoma of the Colon Associated with Inguinal Hernia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Clinical Evaluation of Plasma Thromboplastin Antecedent (PTA) Deficiency.
Authors: Fred C. Conrad
Journal: Annals of Internal Medicine (1964)

s1 October 1964A Clinical Evaluation of Plasma Thromboplastin Antecedent (PTA) Deficiency.Fred C. Conrad, William L. Breneman, Dorothy B. Grisham, B.S.Fred C. ConradSearch for more papers by this author, William L. BrenemanSearch for more papers by this author, Dorothy B. Grisham, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-806_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe reported rate of occurrence of plasma thromboplastin antecedent (PTA) deficiency has been extremely variable, but all investigators list it as the least common of the thromboplastinogen defects. Our studies differ from these experiences and indicate that PTA deficiency is the most common hemophilia or hemophilia-like disorder.A first-stage coagulation abnormality, exclusive of platelet disorders and paraproteinemic states, has been identified in 82 persons at Wilford Hall USAF Hospital over the past 3 years. Fourteen patients had an AHF deficiency; 3 had a PTC deficiency, and 65 persons had a PTA deficiency. The reasons for uncovering such a large patient... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Antonio, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 806-806KeywordsBlood plasmaHemophiliaPlatelets Issue Published: 1 October 1964 PDF DownloadLoading ...
Ablation Therapy for Patients with Supraventricular Tachycardia
Authors: M. Scheinman
Journal: Annual Review of Medicine (1986)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Resuscitation
Authors: Sidney C. Wiggin, Peter Saunders, George A. Small
Journal: New England Journal of Medicine (1949)

Asphyxia NeonatorumAsphyxia neonatorum is the most frequent emergency requiring resuscitation that is encountered in the delivery room. It is characterized by the absence of spontaneous effective respiration. The mechanism of the development of this type of respiratory arrest differs from those classified in the previous section, but the resultant pathological physiology has much in common with them.The difference between asphyxia neonatorum and cardiorespiratory arrest is that in the latter both respiration and circulation cease and must be maintained artificially, whereas in asphyxia neonatorum, it is rare for the heart to stop beating and it is only the respiratory . . .
A NORTH-AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early Colectomy Suggested for Children
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical students and primary care. What makes specialties so special?
Authors: R. G. Petersdorf
Journal: JAMA (1994)

Despite the prominence the oath of Hippocrates has achieved in medicine, Hippocrates did not have a monopoly on health care in ancient Greece. The school of medicine in the town of Cnidus, though seldom mentioned today, was once a healthy rival of the Hippocratic campus. While on the island of Cos, Hippocrates was teaching his students to care for the entire patient; on a nearby peninsula, the Cnidian physicians were focused on specific diseases and on the organs that they thought were involved. The Cnidians were reductionist; they might be called Western civilization's first specialists. But they lived in a time when scientific knowledge was limited, and the school at Cos fared much better than the one at Cnidus. It was the Hippocratic school that stood the test of time, and so it is the Hippocratic oath that our graduating medical students recite.<sup>1</sup> See also p 914. Given that
Dual inhibition of DNA methyltransferase 1 and the histone methyltransferase G9a as a new therapeutic strategy in hepatoblastoma
Authors: Maite G. Fernandez-Barrena, Alex Claveria-Cabello, Leticia Colyn, Juan Carrillo, Julen Oyarzabal, Bruno Sangro, Pau Sancho-Bru, Stefano Cairo, Maria Arechederra, Carolina Armengol, Carmen Berasain, Matías A. Avila
Journal: Journal of Hepatology (2020)
Movement of IgM antibody from blood to bile in rats
Authors: P Hansen
Journal: Hepatology (1991)

The movement from blood to bile of passively injected autologous IgM antibody against horse erythrocytes was studied in rats. Both native and neuraminidase-treated antibody entered bile intact, with the peak titers for both measured between 60 and 90 min after injection. A small part (0.38%) of the injected dose of native antibody and 1.05% of the asialo-IgM antibody appeared in bile over 24 hr. These recoveries represented only a small fraction of the activity, which apparently disappeared from serum over the period. The pathways used by IgM antibody to enter bile were partially assessed. Prior injection of fetuin was found to abrogate the biliary secretion of native antibody and to significantly reduce the recovery of asialoantibody in bile. In contrast, the presence of asialofetuin reduced (but not significantly) the secretion of native antibody and markedly changed the kinetics of appearance of asialo-IgM activity in bile. Some candidate routes to bile can be excluded as unlikely. The parahepatocellular pathway to bile canaliculi appears uninvolved because the secretion of antibody is slow and the inhibitory effects of fetuin argue against secretory component-mediated transport. Instead, two secretory pathways appear to be present. The first appears to be available to both native and asialo-IgM antibody, and may involve the peribiliary capillary plexus. The second route to bile is available to asialo-IgM antibody alone and is probably initiated by binding to the hepatic asialoglycoprotein receptor.
Special Correspondence
Authors: W Crago, Drs Jamieson, Jarvie Shand, Kenna Hood, Norrie Mcswinney, O Reilly, Sydney Jones, W Chisholm, F Quaife, Thomas Kingsbury, Angel Money, Cohen Ellis, T Newmarsh, Milford Lennhoff, Collins Bennet, A Parker, Jas Dick, M Maclaurin
Journal: BMJ (1894)
Errors in Sex Distribution
Authors: Guillaume Leurent
Journal: JAMA Internal Medicine (2016)

ing to electrocardiographic artifacts. 1Pourdjabbar et al underlined that in the diagnosis process ECG testing is only 1 piece of the overall puzzle, which is correct.However, I disagree with their take-home point that biomarkers are essential in the diagnosis of ST-segment elevation myocardial infarctions and for making clinical decisions for these patients.The use of biomarkers are clearly pointed out in the American College of Cardiology Foundation guidelines 2 and the European Society of Cardiology guidelines. 3It is known that biomarker (eg, troponin) elevation is delayed and can be missed in cases of early presenters.Furthermore, because the goal of STsegment elevation management is prompt reperfusion, waiting for the results of biomarkers before initiating reperfusion treatment would only worsen prognosis.
La Greffe Ovarienne: Historique; Résultats Cliniques et Thérapeutiques.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal