tbuckley/cabot-search huggingface dataset:
TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective
Authors: Basil Rapoport, Sandra M. McLachlan
Journal: Endocrine Reviews (2015)

The TSH receptor (TSHR) on the surface of thyrocytes is unique among the glycoprotein hormone receptors in comprising two subunits: an extracellular A-subunit, and a largely transmembrane and cytosolic B-subunit. Unlike its ligand TSH, whose subunits are encoded by two genes, the TSHR is expressed as a single polypeptide that subsequently undergoes intramolecular cleavage into disulfide-linked subunits. Cleavage is associated with removal of a C-peptide region, a mechanism similar in some respects to insulin cleavage into disulfide linked A- and B-subunits with loss of a C-peptide region. The potential pathophysiological importance of TSHR cleavage into A- and B-subunits is that some A-subunits are shed from the cell surface. Considerable experimental evidence supports the concept that A-subunit shedding in genetically susceptible individuals is a factor contributing to the induction and/or affinity maturation of pathogenic thyroid-stimulating autoantibodies, the direct cause of Graves' disease. The noncleaving gonadotropin receptors are not associated with autoantibodies that induce a “Graves' disease of the gonads.” We also review herein current information on the location of the cleavage sites, the enzyme(s) responsible for cleavage, the mechanism by which A-subunits are shed, and the effects of cleavage on receptor signaling.
Journal club
Authors: Sophie Tisi
Journal: Thorax (2020)

Low-dose CT sCreening (LCs) for Lung CanCer reduCes 10-year Lung CanCer morTaLiTyThe outcome of the Dutch-Belgian Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON) trial has been much anticipated.Powered to detect a mortality benefit of LCS in patients at high risk of lung cancer
Chronic, recurrent small-vessel cutaneous vasculitis. Clinical experience in 13 patients
Authors: T. R. Cupps
Journal: JAMA (1982)

The clinical experience in 13 patients with small-vessel cutaneous vasculitis limited to the skin is presented. Within the spectrum of what is referred to as "hypersensitivity vasculitis," this group of patients represents a distinctive clinical entity characterized by (1) clinical, laboratory, and histopathologic features of the hypersensitivity vasculitis group; (2) chronic and recurrent isolated cutaneous vasculitic eruptions; (3) absence of disease progression to systemic involvement during long-term follow-up; and (4) relative unresponsiveness to immunosuppressive therapy, including treatment with corticosteroids (prednisone) and cyclophosphamide. Because this disease remains limited to the skin, potentially toxic immunosuppressive regimens with prolonged daily corticosteroids or cytotoxic agents should be avoided. Treatment of local symptoms, particularly lower extremity pain, remains a difficult treatment problem in some patients. (<i>JAMA</i>1982;247:1994-1998)
Pulmonary Medicine
Authors: Thomas L. Petty
Journal: JAMA (1985)

It is self-evident that the solution to today's problems in pulmonary medicine must lie in prevention. Thus, it is appropriate to devote this review of progress in pulmonary medicine to new developments aimed at either prevention or early identification and intervention. The majority of cases of lung cancer, the commonest cancer in both men and women and still the most rapidly increasing malignancy, could be prevented. Since smoking is by far the greatest risk factor, our task is to convince society that smoking, whether actively or passively, is potentially lethal. One would think that this fact alone would suffice to create a major movement away from tobacco smoking. On average, the regular cigarette smoker sacrifices seven years of life for his habit and addiction. This translates into about 5 1/2 minutes of life for each cigarette smoked.<sup>1</sup>Numerous studies have focused on techniques of smoking cessation, all of which
Older Transportation Workers Face Greater Risk of Dying on the Job
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some Methods of Obtaining Quantitative Structure-Activity Relationships for Quantities of Environmental Interest
Authors: Marvin Charton
Journal: Environmental Health Perspectives (1985)

Methods are described for obtaining quantitative structure-activity relationships (QSAR) for the estimation of quantities of environmental interest. Toxicities of alkylamines and of alkyl alkanoates are well correlated by the alkyl bioactivity branching equation (ABB). Narcotic activities of 1,1-disubstituted ethylenes are correlated by the intermolecular forces bioactivity (IMF) equation. When the data set has a limited number of substituents in equivalent positions the group number (GN) equation, derivable from the IMF equation, can be used for correlation. It has been successfully applied to aqueous solubilities, 1-octanol-water partition coefficients, and bioaccumulation factors and ecological magnifications for organochlorine compounds. A combination of the omega method for combining data sets for different organisms with the GN equation has been used to correlate toxicities of organochlorine insecticides in two species of fish. Toxicities of carbamates have been correlated by a combination of the zeta method and the IMFB equation. The ABB and the GN equations are particularly useful in that they generally do not require parameter tables, and that the parameters they use are error-free. The methods presented here, as shown by the examples given, should make it possible to establish a collection of QSAR for toxicities, bioaccumulation factors, aqueous solubilities, partition coefficients, and other properties of sets of compounds of environmental interest.
Book Review Essentials of Syphilology . By Rudolph H. Kampmeier, M.D. With chapters by Alvin E. Keller, M.D., and J. Cyril Peterson, M.D. 8°, cloth, 518 pp., with 87 illustrations and 52 tables. Philadelphia: J. B. Lippincott Company, 1943. $5.00.
Journal: New England Journal of Medicine (1944)
Percutaneous transluminal angioplasty of aortocoronary saphenous vein graft. Morphologic observations
Authors: M. Famularo
Journal: JAMA (1983)

Numerous reports of percutaneous transluminal angioplasty have demonstrated its clinical usefulness as a nonoperative approach to coronary artery disease. Recently, this technique has been extended to coronary artery bypass grafts. To our knowledge, our report is the first to describe the anatomical changes induced by percutaneous transluminal angioplasty in a saphenous vein aortocoronary bypass graft. (<i>JAMA</i>1983;249:3347-3350)
Update: Interim Guidelines for Health Care Providers Caring for Infants and Children with Possible Zika Virus Infection — United States, February 2016
Authors: Katherine E. Fleming-Dutra, Jennifer M. Nelson, Marc Fischer, J. Erin Staples, Mateusz P. Karwowski, Paul Mead, Julie Villanueva, Christina M. Renquist, Anna A. Minta, Denise J. Jamieson, Margaret A. Honein, Cynthia A. Moore, Sonja A. Rasmussen
Journal: MMWR Morbidity and Mortality Weekly Report (2016)
Searching for the Culprit Agents for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis from a Nationwide Claim Database in Korea
Authors: Min-Suk Yang, Jin Yong Lee, Jayeon Kim, Byung-Keun Kim, Ju-Young Kim, Heung-Woo Park, Sang-Heon Cho, Kyung-Up Min, Hye-Ryun Kang
Journal: Journal of Allergy and Clinical Immunology (2017)
On encountering hopelessness
Authors: L. Shulman
Journal: JAMA (1977)

SOMETIMES we encounter a situation for which we have not been prepared, which confounds us and calls our assumptions into question. Certain patients force such a crisis on us, allowing us in our resolution of it to again come to terms with our commitment. Paradoxically, the situation is not always generated by the seriousness or arcane nature of the patient's disease. Sometimes, in fact, the diseases are much like many others we have seen, unique in their particulars, but so familiar in their clinical presentation that we type them, treat them, and look for no more in them than an expected sequence of laboratory values and clinical findings, unless something stirs us to look deeper, and learn. <h3>Report of a Case</h3> A 78-year-old former baseball player and insurance salesman was brought to the emergency room by his wife, disoriented and unmanageable. His history showed that he had been forgetful and
THE RELATION OF MALARIA TO RENAL DISEASE.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the editors
Authors: Lucy Bird, Kirsty Minton, Olive Leavy, Yvonne Bordon, Gemma Ryan, Craig Nicholson, Man Tse, Simon Bradbrook, Susanne Harris, Vicky Summersby, Patrick Managing, Judith Shadwell, Simon Fenwick, Natalie Smith, Jacques Smit, Laura Corns, Deborah Anthony, Marketing Managers, Tim Redding, Leah Rodriguez
Journal: Nature reviews. Immunology (2009)
IL-33 Promotes Food Anaphylaxis in Epicutaneously-Sensitized Mice By Targeting Mast Cells
Authors: Claire Galand, Juan-Manuel Leyva-Castillo, Raif S. Geha, Juhan Yoon, Michiko K. Oyoshi, Alex Han, Andrew McKenzie, Michael Stassen
Journal: Journal of Allergy and Clinical Immunology (2016)
Elevation of Troponin I Levels in Patients Without Evidence of Myocardial Injury
Authors: Douglas B. Sawyer
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The cardiac isoform of troponin I (TnI) has been touted as 100% specific for myocardial injury.<sup>1-3</sup>While serving on the consult service of a large teaching hospital, we occasionally have evaluated patients with chest pain and elevations of TnI levels in whom we were unable to find any evidence of myocardial injury. We reviewed consecutive patients evaluated at our hospital between January and June 1996 who had elevated serum TnI levels to determine the specificity of this assay for myocardial injury in clinical practice. Troponin I levels were obtained as part of routine clinical practice when myocardial injury was suspected, and 343 patients had 1 or more TnI values of 1.0 ng/mL or greater. Cardiac TnI was measured on the Stratus II analyzer (Baxter Dade, Miami, Fla) with a commercial immunoassay procedure that uses 2 monoclonal antibodies directed against different epitopes on TnI.<sup>4</sup> Of the
Hepatitis B Virus
Authors: Thomas W. Kiernan
Journal: JAMA (1979)

Ten patients designated as hepatitis B surface antigen (HBAg) carriers were screened for inappropriate reactions to their disease. Assessment with a 32-item questionnaire showed three carriers to have underreacted to the risks of HBAg transmission through misunderstandings or denial concerning the disease. One carrier, through severe social withdrawal, showed overreaction to the possibilities of disease transmission. Counseling was provided regarding the risks of HBAg transmission. At a one-month followup, all carriers appeared appropriately aware of the risks of transmission, and one of two carriers referred for psychotherapy showed greatly improved social adjustment. We recommend that persons treating HBAg carriers screen routinely for inappropriate reactions to risks of disease transmission and provide counseling as needed. (<i>JAMA</i>241:585-587, 1979)
Use and Misuse of Pentazocine
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transfusion of Placental Blood to Newborns Delivered by Cesarean Section
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mesenchymal Tumors of the Mediastinum: III. Tumors of Lymph Vessel Origin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wrong Issue Date
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NATIONAL CANCER INSTITUTE: UPDATE ON THE EFFICACY AND AVAILABILITY OF LEVAMISOLE AND 5-FLUORACIL FOR PATIENTS WITH DUKES'C COLON CANCER
Journal: JNCI Journal of the National Cancer Institute (1989)

NATIONAL CANCER INSTITUTE: UPDATE ON THE EFFICACY AND AVAILABILITY OF LEVAMISOLE AND 5-FLUORACIL FOR PATIENTS WITH DUKES'C COLON CANCER Get access JNCI: Journal of the National Cancer Institute, Volume 81, Issue 23, 6 December 1989, Page 1850, https://doi.org/10.1093/jnci/81.23.1850 Published: 06 December 1989
RED CROSS SEALS
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospital Career Structure
Authors: E. Beck, D. Brenton, I. D. L. Brewis, S. B. M. Christie, S. G. Cotton, J. Francis, R. N. Gruneberg, P. Hollins, A. Cameron, B. Elliott, S. Freedman, P. W. N. Gordon, A. Gruneberg, J. Hickman, J. T. Holmes, J. McLachlan, H. Platt, P. G. W. Sharp, R. Souhami, D. S. Thompson, J. Tonge, D. J. Wayne, J. Kersey, R. A. Roxburgh, D. Rubenstein, J. Seymour, M. A. Skivington, G. K. B. West
Journal: BMJ (1968)
DIPG-37. DEVELOPMENT AND CHARACTERIZATION OF DIFFUSE INTRINSIC PONTINE GLIOMA MOUSE MODELS GENERATED BY BRAINSTEM IN UTERO ELECTROPORATION
Authors: Smruti Patel, Rachel Hartley, Heather Bear, Timothy Phoenix
Journal: Neuro-Oncology (2018)

Diffuse intrinsic pontine glioma (DIPG) is a universally fatal pediatric cancer arising in the brainstem of children. Their unique brainstem location and pathology, including limited disruption of the blood-brain barrier (BBB), present a significant challenge to treatment. Developing mouse models that accurately reflect the genetic landscape and brainstem location of DIPG will be critical to delineate the role of newly identified mutations in DIPG pathogenesis. Here we describe the efficient generation of DIPG mouse models by targeted transfection of the developing brainstem using in utero electroporation, and characterize the pathological and molecular features associated with PDGFB, Pdgfra, and H3.3 K27M genetic variants. Both PDGFB and PdgfraD842V expression, in combination dominant negative Trp53 (DNp53), develop fully penetrate high-grade gliomas that display distinct differences in latency, histology, and molecular profiles. Addition of the H3.3 K27M mutation alters gene expression in both PDGFB and PdgfraD842V tumors, but only significantly accelerated PdgfraD842V tumors in this system, likely due to the already aggressive nature of PDGFB tumors. Compared to PDGFB tumors, PdgfraD842V brainstem tumors maintain BBB function. Paracrine effects of PDGFB expression in the tumor microenvironment are associated with disruption of pericyte-endothelial interactions, extracellular matrix remodeling, and increased angiogenesis and BBB disruption. This DIPG mouse modeling system provides a rapid and flexible in vivo platform to perform functional genomic studies to fundamentally advance our understanding of the cellular and molecular basis underlying DIPG, and conduct preclinical studies of molecularly targeted therapies that aim to improve survival rates and outlook for DIPG patients and their families.
Typographical Error in a Percentage in Figure
Authors: Stephen Devries, Walter Willett, Robert Bonow
Journal: JAMA (2019)

discussion of systems for categorizing carbohydrates with regard to glycemia."Glen cites studies that evaluated the lack of a long-term relationship of one specific measurement of carbohydrates to hemoglobin A 1c and fasting glucose.We made no such claims.What we do believe is that medical students should learn the nomenclature of carbohydrates (eg, sugars, starch, fiber) and understand how carbohydrate composition can affect glycemia (GI and GL).This basic knowledge of terminology will provide the conceptual framework needed for students to explain to their future patients why, for example, an apple is preferred over apple juice, why 100% whole-grain bread is preferred over white, and why a bagel, despite the absence of sweetness, can acutely increase blood glucose level.Given the current deficiency of nutrition education in medical training, physicians are often not adequately prepared to address even these fundamental issues.