tbuckley/cabot-search huggingface dataset:
EDP-297, a novel and potent fxr agonist, exhibit robust anti-fibrotic effects with significant liver function in a rat model of non-alcoholic steatohepatitis
Authors: Mozhdeh Sojoodi, Yongtao Wang, Derek J. Erstad, Peter Caravan, Michael Lanuti, Motaz Qadan, Bryan C. Fuchs, Khanh Hoang, Yat Sun Or, Lijuan Jiang, Kenneth K. Tanabe
Journal: Journal of Hepatology (2020)
Gastrointestinal Blood Loss
Authors: Donald H. Loebl
Journal: JAMA (1977)

The feasibility of determining the exact site and amount of drug-induced gastric bleeding was tested. Fourteen patients with rheumatoid arthritis received equivalent therapeutic doses of the antiinflammatory drugs aspirin, 4 gm/day, and fenoprofen calcium, 2.4 gm/day, in randomized order for seven days. Acetaminophen was given for 14 days just prior to each of these periods. By fiberoptic gastroscopy, antral ulceration and acute mucosal lesions were found in seven patients following aspirin ingestion, in one taking fenoprofen, and in none taking acetaminophen. Fecal blood loss in four-day stool collections, quantitated by autologous chromium 51-labeled erythrocytes shed into the stool averaged 5.0 ml/day while taking aspirin, 2.2 ml/day while taking fenoprofen calcium, and 0.8 ml/day while taking acetaminophen. The mean blood loss was greater for those in whom gastric lesions developed while taking aspirin than for those in whom lesions did not develop. The short-term risk of erosive gastritis was greater for aspirin than fenoprofen. (<i>JAMA</i>237:976-981, 1977)
INFLUENCE OF NOXIOUS EFFLUVIA ON THE ORIGIN AND PROPAGATION OF EPIDEMIC DISEASES
Authors: R. D. Grainger
Journal: BMJ (1853)

announced as about to take place, for the purpose of peti- tioning both Houses of Parliament.The Central Council of the AssocrATioN have determined to assemble the profession residing in the city and county of Worcester, as will be seen by their resolutions published at p. 178; and if any of the Counicils of the District Branches have not yet moved in a similar manner, we trust that they will no long,er defer following the advice whichhas beenissued from head-quarters.Thereis absolutely no time left for delay.The voice of the profession, if it is to be effective, must he not onily unanimous and earnest, but it must e imnmediately spoken.We would repeat the words of Dr. SZITn1, published in our last numl)er (p. 1.7):-"Let the p)eriod betwreen ilias andl Easter lIe e)nlxIo?ted! ifa yettinyq) piylb1e7etial 2neetings (and numerozsl sigiwedt petitiuui; aasd duiri-ikq the recess, ichen me.-nbers of lParliwuent ret?erTh to thee coitntr!l, let them be iraited?pon6, a-nd( urqied to htelp ou) just cause."Dr. NAINKIVELL'S sugg-eStiOn (p.178), as to adopting or adapting the formn of pctition Cemiployed by the pretitioners of Torqluay, mzay save a goo(d (leal of trohible, as that peti- tion is correctly expressed andl thoroughly (ed rem.NAkVAL ASSISTA'NT-SURGEONS. I.x no department of the national service is so much money expenldedI for so little puirpose as in the Royal Navy.Ships are built aind inimmeiately takeni to pieces in the most wantton way, just as if the main object of the dockyard authorities was to IIsC -uip a certain amount of public monoey: at all events, so it is, thb thle vaie h the country re- ceives in the shape -e efli.ectivewar ships, is very far from proportion;.to the treasure ithsorhed by the slaipwrights.-den again, witlh thc p,roverlbial obstinacy of incompeteilce and adherence to routinc, a British adniral rarely enters upon his office till he has become physically and mentally unfitted by old age for his highl aind responsible command.The cominon sailors too are so badly treated, that the navy of the Uniitetl States, and our own mercantile navy, com- * At p. 180 will be fotund an accouint of what took place or' Monday night in t"e liousc of Commons with reference to the present treatmenit of naval -IA -4 tnt-II rEonnS + This subject is ably discussed by Dr. CUpenter, in a Valtuable paper on the Predisposing Causeb of Epidenies.-BUiiikand Foreign 3e(dio.Chirur.
"Epidemic"
Authors: Robert L. DuPont
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Your recent editorial (226:660, 1973) took me to task for using "loaded language" when I called heroin addiction in the District of Columbia "epidemic" (<i>N Engl J Med</i>285:320, 1973). The use of the word "epidemic" to describe the increase in heroin addiction during the last decade and the use of the intellectual tools of epidemiology have recently been criticized by several writers. The criticism can be summarized into two basic arguments. Calling heroin addiction<i>epidemic</i>scares people, when we need less fear and more reason to solve this complex problem. The epidemiologic approach to the problem of heroin addiction ignores the fact that drug abuse is significantly different from infectious diseases, and the use of epidemiologic concepts leads to false and dangerous conclusions. The editorial dealt only with the first of these two criticisms. Although the editorial was correct that I did not define the term
Active labour.
Authors: G. W. Theobald
Journal: BMJ (1969)

With regard to the "popular fallacies," it is probable that cephalopelvic disproportion is less common in Dublin than in some centres in Great Britain.During 19101 4,449 deliveries occurred in the combined extern and intern departments of the Rotunda Hospital.2There were five caesarean sections, the forceps rate was 3 6%, the stillbirth rate 3-2%, and the hos- pital perinatal mortality rate was 4-8%.Such
Incorrect Information in Table and Affiliations
Journal: JAMA Neurology (2013)

Olivier Andlauer, MD; Hyatt Moore IV, MSc; Laura Jouhier, MD; Christopher Drake, PhD; Paul E. Peppard, PhD; Fang Han, MD; Seung-Chul Hong, MD, PhD; Francesca Poli, MD; Giuseppe Plazzi, MD; Ruth O’Hara, PhD; Emmanuel Haffen, MD, PhD; Thomas Roth, PhD; Terry Young, PhD; Emmanuel Mignot, MD, PhD
Book Reviews
Authors: M. Valdés, Mark E. Schmidt, Maurizio Fava, Shuyu Zhang, Jill Gonzales, Nancy J. Raute, Rajinder Judge, Maurizio Fava, Mark E. Schmidt, Shuyu Zhang, Jill Gonzales, Nancy J. Raute, Rajinder Judge, S. Fassino, G. Abbate Daga, A. Pierò, G.G. Rovera, Ross J. Baldessarini, S. Nassir Ghaemi, Adele C. Viguera, A. Benabarre, E. Vieta, A. Martinez-Arán, M. Reinares, F. Colom, F. Lomeña, F. Martin, Annette Kjær Fuglsang, Hanspeter Moergeli, Sofia Hepp-Beg, Ulrich Schnyder, Birgit Gottwald, Jörg Kupfer, Isabel Traenckner, Carolina Ganss, Uwe Gieler, Mauro G. Carta, Paolo Serra, Assunta Ghiani, Elisabetta Manca, Maria Carolina Hardoy, Gennaro S. Del Giacco, Giacomo Diaz, Bernardo Carpiniello, Paolo E. Manconi, Deacon Shoenberger, Boudewijn van Houdenhove, Eddy Neerinckx, Patrick Onghena, Ad Vingerhoets, Roeland Lysens, Hans Vertommen
Journal: Psychotherapy and Psychosomatics (2002)

Psychosomatic medicine has developed a great deal in Japan, both in academic and clinical terms.Before this volume, however, such developments were not well known in the western world.The book consists of several articles illustrating the various aspects of consultation liaison psychiatry in Japan, including psychooncology, psychonephrology and transplant medicine.It is an essential reference to understand the Japanese psychosomatic approach to health and disease.
White Piedra
Authors: Amy Kalowitz Bieber, Miriam Keltz Pomeranz, Randie H. Kim
Journal: JAMA Dermatology (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Vaccinia of the eyelid
Authors: J. D. Bybee
Journal: JAMA (1967)

VACCINIA of the eyelid is a rare complication of vaccination considering the frequency of administration of this procedure. Well over 200 cases, however, have been reported in the world literature since the introduction of vaccination in 1796.<sup>1</sup>In large scale vaccination programs, several ocular vaccinial infections have been observed.<sup>2,3</sup>The patient whose case is reported here presented with typical vaccinial blepharoconjunctivitis. The diagnosis was confirmed by virologic and electron microscopic studies. <h3>Report of a Case</h3> A 25-year-old housewife was admitted to Methodist Hospital on Aug 21, 1965, because of a swollen, painful left eye of two days' duration. On Aug 10, a smallpox vaccination over the medial border of the left scapula was performed. On Aug 15, a typical vaccinia reaction was noted at the site of vaccination, with formation of a papule which became vesicular and finally crusted. On Aug 19, the patient noted itching and minimal
Growth and development of an infant receiving all nutrients exclusively by vein
Authors: D. W. Wilmore
Journal: JAMA (1968)

An infant weighing 2,300 gm (5 lb 1 oz) with atresia of the small bowel from the ligament of Treitz to within 3 cm of the ileocecal junction, and partial atresia of the colon, declined postoperatively to 1,816 gm (4 lb) despite vigorous but conventional supportive care. A 30% solution containing all required nitrogen, calories, and essential nutrients was then infused continuously into the superior vena cava for 44 days when gastrointestinal dysfunction precluded enteral feeding. During the period when nutrition was given entirely intravenously, normal growth and development accompanied increases of 5.0 cm (1.9 in) in head circumference, 6.3 cm (2.5 in) in length, and 1,447 gm (3 lb 3 oz) in weight.
Pulmonary Sporotrichosis
Authors: Gerald L. Baum, Roy L. Donnerberg, David Stewart, Wallace J. Mulligan, Louis R. Putnam
Journal: New England Journal of Medicine (1969)

Four cases of pulmonary sporotrichosis have been observed in three institutions in Ohio. Three of these cases represent primary pulmonary infection, and one represents disseminated disease associated with sarcoidosis. The occupational hazard of gardening or handling vegetable produce was noted in three of the four patients. Cavitary lesions observed in three of the patients were treated by pulmonary resection and chemotherapy with amphotericin B and iodides. Three patients were well 10 to 52 months after treatment, but active pulmonary sporotrichosis was found in the fourth case apparently associated with active pulmonary tuberculosis. A possible relation between infection with Sporotrichum schenckii and sarcoidosis or prolonged steroid therapy (or both) in one case is proposed.
Revista Paulista de Medicina, São Paulo
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 481: GRK5 as a Novel DNA-Binding Protein in Cardiomyocyte Hypertrophic Stress
Authors: Ryan Coleman
Journal: Circulation Research (2017)

Introduction: The pathogenesis and progression of heart failure (HF) encompasses aberrations in gene regulation, leading to ventricular remodeling and maladaptive cardiac hypertrophy. A common maladaptation in HF is an increase in the expression level of the G protein-coupled receptor kinase, GRK5. Recently, non-canonical roles for GRK5 have been uncovered that are crucial for the development of maladaptive hypertrophy and these are due to nuclear translocation and accumulation of GRK5. We have shown that GRK5 is a histone deacetylase kinase promoting de-repression of hypertrophic gene transcription through MEF2 and can also facilitate transcriptional activity of NFAT through DNA-binding. The latter is consistent with studies revealing that GRK5 contains a DNA-binding domain. Hypothesis: We hypothesize that the DNA-dependent roles of GRK5 are a mechanism by which GRK5 contributes to gene reprogramming in myocardial hypertrophic stress. Methods: To further study this, neonatal rat ventricular cardiomyocytes overexpressing GRK5 were subjected to α-adrenergic stress with 50μM phenylephrine (PE) or vehicle for 30 minutes to induce nuclear accumulation of GRK5. Chromatin was isolated and GRK5 immunoprecipitation (ChIP) employed to pull-down DNA associated with GRK5 (n=3 PE, n=4 vehicle). Next generation sequencing of this DNA provides an unbiased view of GRK5 DNA binding. Results: The GRK5 ChIP-Seq revealed that GRK5 translocation upon hypertrophic stress leads to multiple promoter, exon, and enhancer DNA-binding events. Gene ontology revealed enrichment of pathways known to be involved in hypertrophy, including the NFAT and Ras pathways. Promoters for genes relevant to cardiac hypertrophy, such as bone natriuretic peptide and early growth response 1 were also found to be enriched by GRK5 immunoprecipitation with PE treatment. In conclusion, we show that during hypertrophic stress, GRK5 mobilizes to the nucleus of myocytes and localizes around diverse genes involved in cardiomyocyte hypertrophy. Further studies in vivo will reveal whether GRK5 has a causal DNA-dependent role in gene reprogramming in HF.
Treatment of Hypoxemia
Authors: E. Leslie Chusid
Journal: JAMA (1970)

A simple, inexpensive, disposable plastic mask for controlled low-concentration oxygen inhalation has been developed. An inspired oxygen concentration of about 24% is obtained with an oxygen flow rate of 1.5 to 2 liter/min through a Venturi device, with negligible rebreathing of carbon dioxide (mean FICO<sub>2</sub>, 0.7%) under the mask. In 68 patients the mask raised the arterial oxygen tension by a mean of 34 mm Hg, whatever the clinical diagnosis or initial Pao<sub>2</sub>. The mean rise in Paco<sub>2</sub>, in patients with hypercapnia, eucapnia, or hypocapnia did not exceed 3 mm Hg during low oxygen inhalation with the new mask. The mask is an economical and well-tolerated method of short- or long-term low oxygen therapy in patients with hypoxemia of varied causes.
Initiation/Promotion versus Complete Carcinogenicity in the Rodent Liver
Authors: John Ashby, B. M. Elliott, P. A. Lefevre, Jerry Styles, E. Longstaff
Journal: Environmental Health Perspectives (1983)

4-N-Pyrrolidinylazobenzene (4N) is a close structural analog of the rodent liver carcinogen 4-dimethylaminoazobenzene (DAB). This structural similarity led us to evaluate it for genotoxic activity in vitro. We observed activity for 4N and DAB in the BHK cell transformation assay and subsequently in the Salmonella mutation assay of Ames. By a curious chance, Scribner, Miller and Miller, probably prompted by the same structural similarity, had synthesized 4N in the 1960s and found it to be noncarcinogenic to the rodent liver using a bioassay test protocol that detected DAB as carcinogenic. These findings were only described following the publication of our observations made in vitro. The conflict that apparently exists between these data can be interpreted in two separate ways. (a) Scribner et al. have suggested that 4N may be a carcinogenic initiator as opposed to a complete carcinogen like DAB. They also suggested that promotion of 4N-treated rodents with phenobarbitone might lead to the production of liver tumors. (b) We have evaluated the simpler concept that the activities observed for 4N in vitro define a carcinogenic potential that is not realized in vivo due to its rapid detoxification, at least in rodents. The first of these explanations implies that pure carcinogenic initiators may form a separate class of genotoxic agents from complete carcinogens, and perhaps of greater interest, that 4N might provide a valuable model compound for the study of carcinogenic promotion in the rodent liver. The second explanation regards potential carcinogenicity as a single property that can be defined in vitro and which may or may not be expressed in vivo depending on the enzymic environments encountered by the test chemical. It is clearly important to evaluate these different propositions in order to aid progress in the study of carcinogenic promotion, especially in the rodent liver. The presentation will describe our recent studies in vitro and in vivo in this connection.
Membership of Education Committees (as of June 15, 1987)
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Monitoring during sedation for endoscopy.
Journal: BMJ (1988)

oblique muscles the eyes become extorted on look- ing down, and the patient experiences torsional diplopia.This is sometimes accompanied by a convergent deviation on depression caused by the loss of abduction (which is the normal secondary action of the superior oblique muscles, to which Dr Sharland refers).In bilateral superior oblique muscle palsies depression of the ceres is also limited when the eyes are converged (and, hence, are in the adducted position).A patient may compensate for the difficulty in maintaining bino- cular single vision on looking down by lowering his chin so as to avoid the need to depress his eyes.
Abstract A04: Recurrent oncogenic mutations in the small GTPase <i>RIT1</i> activate PI3K and MEK.
Authors: Alice H. Berger, Fujiko Duke, Marcin Imielinski, Nathan Kaplan, Jeremiah Wala, Geng-Xian Shi, Douglas A. Andres, Matthew Meyerson
Journal: Clinical Cancer Research (2014)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR02) of the Conference Proceedings. Citation Format: Alice H. Berger, Fujiko Duke, Marcin Imielinski, Nathan Kaplan, Jeremiah Wala, Geng-Xian Shi, Douglas A. Andres, Matthew Meyerson. Recurrent oncogenic mutations in the small GTPase RIT1 activate PI3K and MEK. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr A04.
In This Issue of JAMA Pediatrics
Journal: JAMA Pediatrics (2013)

I n a cross-sectional study, Fakhouri et al (page 223) found that fewer than 4 in 10 elementary schoolaged US children met physical activity and screentime recommendations. Modifiable Determinants of Serum 25-Hydroxyvitamin D Status in EarlyChildhood: Opportunities for Prevention M aguire et al (page 230) found that the most im- portant determinants of 25-hydroxyvitamin D levels in early childhood were current vitamin D supplementation and daily cow's milk intake.
Subhepatic intraperitoneal abscess
Authors: H. J. Berger
Journal: JAMA (1979)

INTRAPERITONEAL abscess is rare in patients without preceding abdominal surgery or trauma. Only about 15% of all subphrenic abscesses develop without these predisposing factors; most are due to a perforated viscus or cholecystitis.<sup>1-3</sup>Because the therapy includes both appropriate antibiotics and surgical drainage, early identification and accurate localization of an abscess are essential for management. Clinical suspicion of an abdominal abscess in a patient who does not have a history of surgery or trauma is usually low. An unusual case of an intravenous drug abuser with a large subhepatic abscess is described to highlight the pertinent clinical and roentgenographic findings. <h3>Report of a Case</h3> A 27-year-old man with a long history of heroin and alcohol abuse came to the emergency room at night with a history of three weeks of increasing right upper quadrant and right lower chest pain, worse on deep inspiration. He also complained of daily fever,