tbuckley/cabot-search huggingface dataset:
The Role of Fear in Electroconvulsive Treatment
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
poster session 6: post-registration clinical research
Authors: P Van Erp, A Gelderblom, M Zhao, J Li, R Van Der Straaten, Y Zabelina, J Nortier, J Ouwerkerk, H Guchelaar, S Baker, A Bearz, C Simonelli, R Talamini, S Spazzapan, M Berretta, E Vaccher, P Monini, C Sgadari, B Ensoli, & Tirelli
Journal: Annals of Oncology (2006)
REGIONAL DISEASES AND THE SESSIONS OF THE AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eosinophilia-Myalgia Syndrome—New Mexico
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spontaneous bacterial peritonitis: a historical perspectiveKerr DNS, Pearson DT, Read AE. Infection of ascitic fluid in patients with hepatic cirrhosis [Gut 1963; 4: 394–398]; Conn HO. Spontaneous peritonitis and bacteremia in Laennec's cirrhosis caused by enteric organisms. A relatively common but rarely recognized syndrome [Ann Intern Med 1964; 60: 568–580]
Authors: G GARCIATSAO
Journal: Journal of Hepatology (2004)
AMA's Population Control Program Keyed to Physician Role as Counselor
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autogenous vein grafts for femoropopliteal occlusion
Authors: W. A. Dale
Journal: JAMA (1966)

Experience during the past decade has led to considerable agreement concerning the proper operative indications and optimal methods of surgical repair of peripheral arterial occlusions. Although some details remain unsettled, the body of accumulated experimental and clinical evidence has led to the concept that autogenous tissues are more suitable than are synthetic materials for vascular repair wherever possible. While synthetic-tube grafts are mandatory for certain vascular replacements, such as abdominal aneurysms, they should be avoided in favor of either thromboendarterectomy or autogenous vein grafts<sup>1</sup>or combinations for repairs of the femoropopliteal system. Acceptable experience has now been reported by a number of different surgeons and the continued longterm-patency rate of autogenous vein grafts has proved to be relatively good even in the face of slow continuation of degenerative disease of the peripheral artery which has been repaired.<sup>2</sup> <h3>Surgical Indications</h3> Recommendation for surgical repair of the femoropopliteal arterial system
Correction
Journal: BMJ (1951)

ANY QUESTIONS ?small, to be overlooked even in the course of a "cold" laparotomy.In the presence of inflammation it would be still easier for the offending organ to be missed.The fact that the patient made an uneventful recovery does not, of course, rule out the diagnosis of appendicitis.If the appen- dix was truly absent then it would be tempting to suggest the presence of an occult and inflamed caecal diverticulum to explain the typhlitis.Congenital Fibrosis of the Pancreas Q.-What is the aetiology of congenital fibrosis of the pancreas?I have a patient who has had two children, in 1940 and 1949, with normal pregnancies and deliveries, who both died of fibrosis of the pancreas at about 6 months.
Immunization
Authors: Albert B. Sabin
Journal: JAMA (1981)

Acute respiratory and diarrheal diseases cannot be expected to be effectively controlled by vaccines for a variety of reasons but largely because of the great multiplicity of causative agents. Measles could be eradicated by appropriate strategies. Paralytic poliomyelitis caused by polioviruses can be controlled by oral poliovirus vaccine in both developed and undeveloped countries but by different strategies. Vaccines cannot be expected to have a beneficial effect on recurrent genital, ocular, and facial herpes. Since naturally acquired immunity does not prevent subsequent fetal intrauterine infection with cytomegalovirus, it is still necessary to establish whether it can nevertheless prevent congenital defects. Prospective heptitis B vaccines cannot be expected to be useful in the general population. There is reason to believe that both varicella and herpes zoster could be prevented by widespread use of the Japanese attenuated vaccine. (<i>JAMA</i>1981;246:236-241)
Oxidation-Reduction Reactions of Metal Ions
Authors: Dean E. Carter
Journal: Environmental Health Perspectives (1995)

Several metal or metalloid ions exist in multiple oxidation states and can undergo electron transfer reactions that are important in biological and envi- ronmental systems.There are endogenous metal ions such as iron, copper, and cobalt that participate in oxidation-reduction reactions with species of oxygen like molecular dioxygen, superoxide, and hydrogen peroxide.These reactions may be modulated by endogenous reducing agents such as glutathione, ascorbate, and tocopherol.The reactions can be described in terms of thermodynamics through the use of standard electrode poten- tials.A favorable reaction will depend on the concentrations of the reactants and may depend on the pH and/or on the presence of organic ligands that form complexes with the metal or metalloid.Arsenate (As(V)) can react with glutathione in buffered aqueous solutions to produce arsenite (AslIl)) and oxidized glutathione.This reaction may be important in the methylation reactions of arsenic.Arsenic species can decrease the red blood cell levels of reduced glutathione, but the products of oxidation and the mechanism of oxidation are more complex than those found in water alone.Chromium (VI) is thought to interact with DNA after first reacting with a reducing agent such as glutathione to form lower oxidation states of chromium.These examples illustrate the importance of oxidation-reduction reactions for toxic metals and metalloids.-
Practical Gastroscopy.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lipid Peroxidation in Adrenal and Testicular Microsomes
Authors: Walter C. Brogan, Philip R. Miles, Howard D. Colby
Journal: Environmental Health Perspectives (1981)

Studies were carried out to determine the actions of and interactions between ascorbate, NADPH, Fe2 +, and Fe3 + on lipid peroxidation in adrenal and testicular microsomes.Ascorbate- induced malonaldehyde production was maximal in adrenal and testicular microsomes at an ascorbate concentration of 1 x 10M.Fe2 +, at levels between 10 and 10-3M, produced concentration-dependent increases in lipid peroxidation in adrenal and testicular microsomes; Fe2 + had a far greater effect than Fe3 + in both tissues.In liver microsomes, by contrast, Fe2 + and Fe3`had quantitatively similar effects on lipid peroxidation.NADPH alone had no effect on malonaldehyde production in adrenal or testicular microsomes.However, in the presence of low Fe2+ concentrations (106M), NADPH stimulated adrenal malonaldehyde production.The stimulation of lipid peroxidation by NADPH plus low Fe2 + was not demonstrable in testicular microsomes nor in adrenal microsomes which had been heat-treated to inactivate microsomal enzymes.Testicular malonaldehyde production was stimulated by NADPH if Fe3 + (5 x 10-5 to 1 x 103M) was added to the incubation medium; the stimulation was not demonstrable in heat-treated microsomes.Fe3 +plus NADPH had little effect on adrenal lipid peroxidation.In the presence of high Fe2+ levels (10-3M), NADPH produced a concentration-dependent inhibition of adrenal lipid peroxidation; the inhibition was fully demonstrable in heat-treated microsomes.NADPH similarly inhibited ascorbate-induced lipid peroxidation in adrenal microsomes.In testicular microsomes, NADPH did not inhibit ascorbate or Fe2 + -induced lipid peroxidation.The results indicate that various endogenous substances may be important in the control of adrenal and testicular lipid peroxidation and that the nature of the regulation differs from tissue to tissue.
Abstract 2469: Circadian Blood Pressure Variation and Left Atrium Size in the Early Stages of Essential Hypertension: The Role of Pulse Pressure and Nocturnal Blood Pressure Fall
Authors: Efstathios Taxiarchou, Costas Tsioufis, Dimitris Tsiachris, Dimitris Syrseloudis, Ioannis Giatrakos, Dimitris Tousoulis, Ioannis Kallikazaros, Christodoulos Stefanadis
Journal: Circulation (2008)

Introduction: Left atrial (LA) enlargement is a common finding in hypertensive patients and might be an index for future adverse cardiovascular events. Similarly, increased pulse pressure (PP) as well as absence of nocturnal blood pressure (BP) fall is associated with unfavourable outcome in this setting. Hypothesis: Ambulatory BP parameters may be correlated with LA size in essential hypertension. Methods: 332 consecutive, newly diagnosed subjects (aged 52±10 years), with untreated stage I–II essential hypertension [office BP =152/98 mmHg] were classified according to their nocturnal BP fall on 24-hour ambulatory BP monitoring to non-dippers (those with&lt;10% nocturnal systolic and diastolic BP fall, n=194) and dippers (the remaining subjects, n=138). All subjects underwent complete echocardiographic study and LA volume was indexed for body surface area to estimate LA volume index (LAVI). Results: Non-dippers compared to dippers did not differ regarding age, sex, office BP and biochemical profile (p=NS for all cases). However, non-dippers compared to dippers had significantly increased 24-h systolic BP (138±14 vs 135±11 mmHg, p&lt;0.05), 24-h pulse pressure (PP) (53±9 vs 51±8 mmHg, p&lt;0.05) and night PP (53±10 vs 47±8 mmHg, p&lt;0.001) as well as left ventricular mass index (108±28 vs 101±26 gr/m 2 , p&lt;0.05) and relative wall thickness (0.44±0.07 vs 0.42±0.07, p&lt;0.05), while they did not differ regarding LA diameter (3.95±0.39 vs 3.86±0.39 cm, p=NS) and LAVI (24.1±6.3 vs 23.5±6.1 ml/m 2 , p=NS). In the entire population LA diameter and LAVI exhibited positive relationships with 24-h PP (r=0.153, p=0.005 and r=0.251, p&lt;0.001, respectively), day PP (r=0.150, p&lt;0.01 and r=0.256, p&lt;0.001, respectively) and night PP (r=0.148, p&lt;0.01 and r=0.234, p&lt;0.001, respectively). Multiple regression analysis models revealed that among components of ambulatory BP, only 24-h day PP was an independent predictor of LAVI (β=0.256, p&lt;0.001). Conclusions: Ambulatory PP and particularly day PP but not circadian BP variation seems to determine the LA enlargement in hypertensive patients. Whether the abovementioned association contributes to the high cardiovascular risk observed in patients with wider day PP remains to be determined in future studies.
853 THE HEP-NET B/C CO-INFECTION TRIAL: A PROSPECTIVE MULTICENTER STUDY TO INVESTIGATE THE EFFICACY OF PEGYLATED INTERFERON-A2B AND RIBAVIRIN IN PATIENTS WITH HBV/HCV CO-INFECTION
Authors: A. Potthoff, H. Wedemeyer, W.O. Boecher, T. Berg, S. Zeuzem, J. Arnold, U. Spengler, K. Gruengreiff, T. Kaeser, A. Kassai, M. Schuchmann, A. Bergk, N. Forestier, K. Deterding, M.P. Manns, C. Trautwein
Journal: Journal of Hepatology (2008)
Ventricular ectopy. History, epidemiology, and clinical implications
Authors: M. J. Horan
Journal: JAMA (1984)

IS VENTRICULAR ectopy always a manifestation of a disease process or can it be found in normal persons? When present, should ventricular ectopy always be treated? To answer these questions, one must delve into medical history, a history rich in anecdote and opinion but muddled in its distinction between disease and health. We review herein the historical development of knowledge about, and attitudes toward, ventricular ectopy, the recent reports delineating patients with ventricular ectopy into prognostically different subsets, and the current approach to the treatment of patients with ventricular ectopy. <h3>Historical Perspective</h3> Although the art of palpating the pulse was practiced as early as 500 BC in ancient China,<sup>1</sup>it was not until the second century BC that Herophilus described what we now recognize as extrasystoles.<sup>2</sup>However, writers after Herophilus did not make reference to extrasystoles per se but rather talked about the "intermittent pulse." The most influential
INTERNAL HEMORRHAGIC PACHYMENINGITIS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Impact of Exercise Training Compared to Caloric Restriction on Hepatic and Peripheral Insulin Resistance in Obesity
Authors: Robert H. Coker, Rick H. Williams, Sophie E. Yeo, Patrick M. Kortebein, Don L. Bodenner, Philip A. Kern, William J. Evans
Journal: Endocrine Reviews (2009)

It has been difficult to distinguish the independent effects of caloric restriction versus exercise training on insulin resistance. Utilizing metabolic feeding and supervised exercise training, we examined the influence of caloric restriction vs. exercise training with and without weight loss on hepatic and peripheral insulin resistance. Thirty-four obese, older subjects were randomized to: caloric restriction with weight loss (CR), exercise training with weight loss (EWL), exercise training without weight loss (EX), or controls. Based on an equivalent caloric deficit in EWL and CR, we induced matched weight loss. Subjects in the EX group received caloric compensation. Combined with [6,62H2]glucose, an octreotide, glucagon, multistage insulin infusion was performed to determine suppression of glucose production (SGP) and insulin-stimulated glucose disposal (ISGD). Computed tomography scans were performed to assess changes in fat distribution. Body weight decreased similarly in EWL and CR, and did not change in EX and controls. The reduction in visceral fat was significantly greater in EWL (−71 ± 15 cm2) compared to CR and EX. The increase in SGP was also almost 3-fold greater (27 ± 2%) in EWL. EWL and CR promoted similar improvements in ISGD [+2.5 ± 0.4 and 2.4 ± 0.9 mg·kg fat-free mass (FFM)−1·min−1], respectively. EWL promoted the most significant reduction in visceral fat and the greatest improvement in SGP. Equivalent increases in ISGD were noted in EWL and CR, whereas EX provided a modest improvement. Based on our results, EWL promoted the optimal intervention-based changes in body fat distribution and systemic insulin resistance.
A Quantitative Trait Locus Analysis of Social Responsiveness in Multiplex Autism Families
Authors: Jacqueline Duvall
Journal: American Journal of Psychiatry (2007)

Objective: Autism is a complex genetic disorder with a highly heterogeneous phenotype defined by repetitive behaviors, language deficits, and problems with reciprocal social interactions. The authors present the first genome-wide scan for a social endophenotype in autism using the Social Responsiveness Scale, which provides a quantitative measure of autistic-like behavior, primarily focused on social relatedness. Method: A nonparametric quantitative genome scan was performed using the Social Responsiveness Scale in a cohort of about 100 families with two or more autistic probands from the Autism Genetic Resource Exchange to identify autism loci. To determine which additional loci were detected, linkage analysis with the same autism cohort using the qualitative diagnosis of autism was performed. To assess whether there were likely to be sex-specific genetic risk factors, the cohort was stratified by the sex of affected individuals. Results: The quantitative Social Responsiveness Scale genome scan identified two loci on chromosomes 11 and 17, with the highest score on chromosome 11 (z=3.22). In contrast, no linkage signals reached significance in the Autism Diagnostic Interview-Revised qualitative scan. The Social Responsiveness Scale scan with only male affecteds identified the same signals on chromosomes 11 and 17, as well as three other regions on chromosomes 4, 8, and 10. Conclusions: This study demonstrates the utility of the Social Responsiveness Scale quantitative endophenotype to detect autism-related genetic loci using quantitative behavioral information that may more closely relate to underlying genetic factors.
Viral Hepatitis
Authors: Joan P. Giles
Journal: JAMA (1969)

The serum immunoglobulin response was studied in 30 children with infectious hepatitis, MS-1 type and in 28 children with infectious hepatitis, MS-2 type. MS-1 is typical infectious hepatitis (IH) and MS-2 resembles serum hepatitis (SH). IgG, IgM, and IgA levels were determined during the incubation period and acute and convalescent phases of the disease. Infectious hepatitis was characterized by a high increase in IgM levels occurring three to four days after the first evidence of abnormal serum glutamic oxaloacetic transaminase (SGOT) activity. The elevated IgM levels returned to normal 5 to 35 days later. In contrast, SH was usually characterized by only slightly elevated to normal IgM levels during the acute stage of the disease. These studies indicate that the results of serial determinations of immunoglobulin levels performed in conjunction with serial SGOT and thymol turbidity determinations should provide useful data for the differentiation of IH from SH.