Alcohol Use and Diabetes Mellitus
Authors: Luca Mascitelli, Francesca Pezzetta
Journal: Annals of Internal Medicine (2004)

Letters7 September 2004Alcohol Use and Diabetes MellitusLuca Mascitelli, MD and Francesca Pezzetta, MDLuca Mascitelli, MDFrom Casa di Cura Cittă di Udine, 33100 Udine, Italy, and Ospedale di Tolmezzo, 33028 Tolmezzo, Italy.Search for more papers by this author and Francesca Pezzetta, MDFrom Casa di Cura Cittă di Udine, 33100 Udine, Italy, and Ospedale di Tolmezzo, 33028 Tolmezzo, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-5-200409070-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their review, Howard and colleagues (1) found that moderate alcohol consumption was inversely associated with risk for diabetes mellitus and with incidence of CHD in persons with diabetes. However, among the mechanisms underlying this beneficial effect, they did not mention the anti-inflammatory action of alcohol. There is mounting evidence that low-grade systemic inflammation is associated with an increased risk for diabetes (2). Furthermore, an ongoing inflammatory response may be contributing to the accelerated atherogenesis in diabetic patients (3). Since light to moderate alcohol consumption has been shown to be associated with lower levels of inflammatory markers ...References1. Howard AA, Arnsten JH, Gourevitch MN. Effect of alcohol consumption on diabetes mellitus: a systematic review. Ann Intern Med. 2004;140:211-9. [PMID: 14757619] LinkGoogle Scholar2. Pradhan AD, Cook NR, Buring JE, Manson JE, Ridker PM. C-reactive protein is independently associated with fasting insulin in nondiabetic women. Arterioscler Thromb Vasc Biol. 2003;23:650-5. [PMID: 12692007] CrossrefMedlineGoogle Scholar3. Mooradian AD. Cardiovascular disease in type 2 diabetes mellitus: current management guidelines. Arch Intern Med. 2003;163:33-40. [PMID: 12523914] CrossrefMedlineGoogle Scholar4. Albert MA, Glynn RJ, Ridker PM. Alcohol consumption and plasma concentration of C-reactive protein. Circulation. 2003;107:443-7. [PMID: 12551869] CrossrefMedlineGoogle Scholar5. Volpato S, Pahor M, Ferrucci L, Simonsick EM, Guralnik JM, Kritchevsky SB, et al . Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: the Health, Aging, and Body Composition study. Circulation. 2004;109:607-12. [PMID: 14769682] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Casa di Cura Cittă di Udine, 33100 Udine, Italy, and Ospedale di Tolmezzo, 33028 Tolmezzo, Italy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Alcohol Consumption on Diabetes Mellitus Andrea A. Howard , Julia H. Arnsten , and Marc N. Gourevitch Alcohol Use and Diabetes Mellitus Andrea A. Howard , Julia H. Arnsten , and Marc N. Gourevitch Alcohol Use and Diabetes Mellitus Hirohito Sone , Nobuhiro Yamada , Sachiko Mizuno , Rei Aida , and Yasuo Ohashi Metrics 7 September 2004Volume 141, Issue 5Page: 409KeywordsAlcohol consumptionAlcoholsAtherosclerosisCongenital heart diseaseDiabetes mellitusInflammation ePublished: 7 September 2004 Issue Published: 7 September 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...