tbuckley/cabot-search huggingface dataset:
Maternal cigarette smoking and the ghost of Yerushalmy--will it ever rest?
Authors: P. R. Burch
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I read with great interest Dr Cilley's<sup>1</sup>letter concerning "intern's neck." I well remember suffering from that malady when I was a house officer. Fortunately, I hit upon a solution that relieved the symptoms somewhat without having to wait for advancement to a higher postgraduate-year level: by designing cloth pockets that would accept my diagnostic equipment and putting belt loops on these pockets, I was able to create a "utility belt" of diagnostic instruments, which I wore around my waist. It gave me a somewhat bloated appearance, but my pelvic girdle was clearly better suited for carrying this much weight than was my pectoral girdle. As a dividend, all of my instruments were readily available in emergencies (I was more than once referred to as a "walking crashcart") and I never lost a single instrument to theft, despite the fact that I trained at a notorious
Patients offered treatment for CHD need full information to make decision
Journal: BMJ (1998)

Clinical management of meningococcal disease Coning may occur without lumbar puncture being doneEditor-Wylie et al do not give the ages of their 252 patients with meningococcal disease, but their recommendation for fewer lumbar punctures should be interpreted cautiously in children. 1 Four deaths were attributed to lumbar puncture, which was done in 198 patients.Two patients deteriorated after lumbar puncture, and postmortem examination showed brainstem herniation.Even when lumbar puncture is not performed, however, patients with meningococcal disease can deteriorate after admission and can cone secondary to raised intracranial pressure.A causal relation in these two cases is not proved.In two patients antibiotic treatment was delayed because initial examination of cerebrospinal fluid was normal.This is a criticism of clinicians, not a risk of lumbar puncture.The risk of cerebrospinal fluid initially giving false negative results and the difficulty of diagnosing meningitis clinically in young children are both recognised.If an ill child warrants a lumbar puncture then he or she should receive antibiotics for 48 hours pending the results of culture, irrespective of the initial results of microscopy.Lumbar puncture may be dangerous if patients have hypotension, coma, raised intracranial pressure, or focal signs and is unnecessary if there is a typical rash.In a series of 445 children with meningitis, the two children with meningococcal infection and cerebral herniation had contraindications to lumbar puncture. 2Lumbar puncture must be performed more readily in children than adults because of the difficulty of diagnosing meningitis clinically.In 86 children with meningococcal meningitis, only 34 had a typical haemorrhagic rash, and not always at presentation. 3 In Wylie et al's series, lumbar puncture gave a positive result initially in 177 of 198 cases and an overall positive result in 186.In children, a clinical diagnosis of meningitis is unlikely to have a similar sensitivity of 89-94%.Moreover, it is unclear how often a positive culture was obtained from another site in the 120 cases that yielded meningococci; molecular biological techniques give no information on antibiotic sensitivity.If fewer lumbar punctures are done in children with meningitis some will be missed and the start of treatment will be delayed.This increases the risk of death, 4 possibly above the 2% attributable to lumbar puncture in this series.Wylie et al have shown a high sensitivity and low mortality from lumbar puncture.Before recommending that the procedure be used less we need to be reassured that clinical diagnosis alone does not result in worse sensitivity and mortality, particularly in children.
Annual and New Year's Day Alcohol-Related Traffic Fatalities—United States, 1982-1990
Journal: JAMA (1992)

Traffic crashes are the leading cause of death in the United States for all age groups from 1 through 34 years (1), and almost half of these fatalities are alcohol-related (2,3); an estimated 40% of all persons may be involved in an alcohol-related traffic crash sometime during their lives (3). During holiday periods, the incidence of traffic fatalities and of alcohol-related traffic fatalities (ARTFs) tends to be higher than during nonholiday periods (4,5). This report summarizes data from the National Highway Traffic Safety Administration's (NHTSA) Fatal Accident Reporting System on trends in ARTFs in the United States from 1982 through 1990 both annually and for January 1 of each year. In addition, a quarterly table (pages 838-9 of this issue) presents data on alcohol involvement in fatal motor-vehicle crashes in the United States for October-December 1990.
Bacterial Meningitis — A Review of Selected Aspects
Authors: Morton N. Swartz, Philip R. Dodge
Journal: New England Journal of Medicine (1965)

Factors Influencing MortalityIn this series the highest mortality rate among the three major types was in pneumococcal meningitis (Table 2). Weinstein55 has indicated that the presence of advanced age, coexisting illnesses, coma, delay in instituting therapy and the presence of bacteremia contribute to a poor prognosis in this disease. Our results are in keeping with this. Bacteremia was demonstrated in all the fatal cases and in over 50 per cent of the entire group of patients; the overall mortality in the current series was 29 per cent. However, 4 of the deaths were not directly attributable to the meningitis . . .
Errors in Data Input in Results, Figure, and Table
Authors: Meredith Snook, Anthony Kontos
Journal: JAMA Pediatrics (2017)

Finally, Benvenga et al provide suggestions for future research with which we agree and discuss in our conclusion 1 including (1) expanding this preliminary study to a larger sample with additional follow-up and (2) conducting hormonal and imaging assessments to better understand the association between concussion and potential consequences of subsequent hypothalamic-pituitary-adrenal axis dysfunction.In conclusion, we appreciate the authors' commentary and agree that there is a need for more research and awareness of the effects of concussion in both female and male patients.
Contributors to this Issue
Authors: Frank Austen, Rrchard -I Blng, Richard Bryant, G Burch, Maroaket Cook, Leon Cudkowicz, Robert Duff, Jean Ginsburg, Ernest Greene, Katharine Gullixson, Stephen Hajdu, John Hannon, Charles Hogancame, William Holland, Robert Joy, Milton Kahdesch, Louis Ivatz, Clyde Kratochvil, Peter Kro, Nlels Lassex, Edward Leonard, Lawrence Lilienfield, H Assistant, Victor Lorber, Robert Mcbroom, James Mccubbin, Paul Mazel, Quillian Murphy, Tom Xorman, K North, D Phil, Robert Weal, Irvixe Page, George Peirce, Lysle Peterson, Ruth Pick, James Randall, John Sayen, Warner Sheldon, R Shipley, Jose Simoes, E Silva, Jeremiah Stamler, Wilbur Thomas, John Tilden, Sally Weiss, N Werthessen
Journal: Circulation Research (1958)
PERISCOPIC REVIEW
Journal: BMJ (1854)

10hO.t guss in the isrdciefunctions have occurred,ao it is now that the huband had some time an- ~ssd.nt1ysufered from primary symptoms-when under *u5 circumstances, such uterine derangement resists ra- tioal and woll directed measures of treatment, and more- onr becomes complicated with affections of the throat, akin, or Periosteum, similar to those met with in persons suf- fu4ng from constitutional syphilis-then it appears to me that we are bound to take the question into our most siOus consideration; and if doubt or suspicion exists, to sence of arsenic, we have but to reduce the water by evapora- tion to one-fortieth, and to treat thie residue with Mfarsh's apparatus.It is found combined with soda, most probably as an arseniate; and M. Thenard estimates the amount of arseniate of soda as one-sixtieth of a grain to a quart of the water.We cannotValley.
Patients with somatisation disorders need considered explanations
Journal: BMJ (1999)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Patients with somatisation disorders need considered explanations Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Intrauterine devices
Journal: JAMA (1990)

<h3>In Reply.—</h3> In response to Dr Glass, my editorial suggested that flight attendants (and consequently passengers) might benefit from receiving basic life support training, eg, learning to clear a foreign object from the throat, stop an acute hemorrhage, or perform cardiopulmonary resuscitation. The fact that flight attendants might be trained as emergency medical technicians was meant to be tongue-in-cheek. Dr Glass' proposal to have at least one on-board flight attendant trained as an emergency medical technician might one day prove to be useful, but from the airlines' point of view is currently impractical. Crew schedules being what they are (attendants bid for flights on a month-to-month basis), trying to ensure one emergency medical technician on each flight would prove to be a logistic nightmare (not even considering the havoc created in crew schedules by canceled flights, weather delays, and crew illnesses). Dr Glass has accurately characterized what is probably the
Only Two Fatty Acids Noted in Cholesterol Increase
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 154: Defective calcium signaling pathway highlights the mutational landscapes of liver metastasis from colorectal and breast cancer
Authors: Fangfang Song, Xiangchun Li, Yuexin Liu, Hong Zheng, Haixin Li, Jun Wang, Wei Zhang, Kexin Chen
Journal: Cancer Research (2016)

Abstract Background Imaging-based early detections of colorectal cancer (CRC) and breast cancer (BC) have significantly improved clinical outcome of these two common cancers. However, when metastasis to distant organs (e.g. liver) occurs, few therapeutic options are currently available. Recent advances in the next-generation sequencing technologies have revolutionized our possibilities to precisely profile all the genetic changes involved in the evolutionary process of individual cancers. To gain insight into genetic and molecular underpinning of metastasis, we performed whole exome sequencing of paired primary and metastases samples from seven CRC/BC patients. Candidate gene mutations were orthogonally validated by targeted sequencing on 28 paired samples including an additional 21 matched primary and metastatic tumors. Results We found that the mutational spectra of metastases were highly heterogeneous. A pairwise comparison between primary and metastatic samples indicated many point mutations were exclusively enriched either in primary tumor or metastases or were present in a sharing pattern between them, showing a lesion-specific genetic difference. Besides the known and novel mutations in APC, TP53, KRAS genes, we discovered 64 significantly mutated genes that were associated with liver metastases from CRC or BC, 9 of which were metastasis specific. Notably, genetic aberrations in calcium signaling pathway genes (GPR98, SYT6, TACR3, CYSLTR1, RYR3, and CACNA1A) were somatically mutated in liver metastases in 29% of CRC and BC cases, indicating that calcium-dependent signaling plays a key role in distant metastasis. Conclusions These results begin to define the genetic basis underlying liver metastasis from CRC/BC and identify potential therapeutic targets. Citation Format: Fangfang Song, Xiangchun Li, Yuexin Liu, Hong Zheng, Haixin Li, Jun Wang, Wei Zhang, Kexin Chen. Defective calcium signaling pathway highlights the mutational landscapes of liver metastasis from colorectal and breast cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 154.
LECTURES ON INSANITY, DELIVERED AT THE BRISTOL MEDICAL SCHOOL DURING THE SUMMER SESSION OF 1855
Authors: J. G. Davey
Journal: BMJ (1855)

the Eat Axa ,s, in addition to Claics and Gmeral Ji tun.OLAVSi XXVIII.The word "and convenient", after "as far as is practicable", are expunged.
THE NATURE AND SIGNIFICANCE OF HEART SYMPTOMS
Authors: J. Mackenzie
Journal: BMJ (1922)

a series of articles on "N New methods of studying affections of the heart."'Tlle articles were the outcome of a researclh in wlhich I had been engaged for nearly twenty years.A basis was laid for the differentiation of abnormal rhythms, and thle practical importance of the research was illustrated by the action of digitalis.The varied and seemingly capricious effect of digitalis on the lhuman heart was demonstrated to be due to tlle fact that digitalis may act in one way on a diseased heart and anotlher on a normal heart, and that the drug may act differently in different diseases.Althouglh the methods lhave been greatly improved, especially since the introduction of tlle ink polygraplh and the electro-cardiograplh, and a great deal of lightlhas been tlhrown upon the mechanism of ab.normal rlhytllms, little real advancelhas been made in the understanding of matters essential for the intelliaent practice of medicine, suclh as the significance of symptoms and the effects of remedies.It haslong been evident that a new concept was needed if these essentials were to be acquired.At the Institute for Clinical Researcll at St. Andrews we
Goals, Results, and Limitations of Vocal Rehabilitation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CASE OF LOCALIZED ARGYRIA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Photobiological Studies with Dioxetanes in Isolated DNA, Bacteria, and Mammalian Cells
Authors: Waldemar Adam, Axel Beinhauer, Thomas Mosandl, Chantu Saha-Moller, Franklin Vargas, Bernd Epe, Elvira Muller, Dietmar Schiffmann, Dieter Wild
Journal: Environmental Health Perspectives (1990)

1,2-Dioxetanes, efficient chemical sources of triplet excited carbonyl compounds, were observed to be genotoxic in isolated DNA, bacteria, and cultured mammalian cells. In superhelical DNA of bacteriophage PM2, various alkyl- and hydroxyalkyl-substituted dioxetanes (1) induced predominantly endonuclease-sensitive base modifications and only few single strand breaks. With a specific endonuclease a small fraction of the base modifications was identified as pyrimidine dimers. The psoralen dioxetane (2a) or PsD bound photochemically to calf thymus DNA at the alpha-pyrone ring of psoralen (fluorescence measurements). Photobinding was also observed when calf thymus DNA was incubated with psoralen and 3-hydroxymethyl-3,4,4-trimethyl-1,2-dioxetane. In Syrian hamster embryo fibroblasts and HL-60 cells, dioxetanes induced DNA single strand breaks. The alkyl- and hydroxyalkyl-substituted dioxetanes 1 and 2 were efficiently inactivated by cysteine, glutathione, ascorbic acid, tocopherol, NADH and FADH2. While dioxetanes 1 and 2 were not mutagenic in Salmonella typhimurium strain TA100, benzofuran dioxetanes 3 exhibited substantial effects. Further data imply that presumably a mutagenic intermediate with a lifetime of a few minutes is produced from the benzofuran dioxetane.
Torture
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistence of hepatitis B virus DNA in the liver after loss of HBsAg in chronic hepatitis B
Authors: T Fong
Journal: Hepatology (1993)

To determine whether patients with chronic hepatitis B who lose hepatitis B virus DNA and HBsAg from the serum completely resolve the hepatitis and virus infection, we evaluated serum and liver tissue from 11 patients who had lost HBsAg. These patients were evaluated for clinical, histological and serological features and for hepatitis B virus DNA by use of hybridization and polymerase chain reaction techniques. Liver biochemical test results were normal in all except two patients who had mild aminotransferase elevations. All sera were negative for hepatitis B virus DNA by direct hybridization, and only one was positive transiently by polymerase chain reaction. Liver histology was abnormal in all patients, but the changes were mild and markedly improved compared with biopsy specimens taken before loss of HBsAg. Liver tissue from 10 patients was positive for hepatitis B virus DNA by polymerase chain reaction but not by direct hybridization. These findings indicate that loss of HBsAg is associated with marked improvements in clinical and serum biochemical features of chronic hepatitis B, yet mild degrees of hepatitis and low levels of viral DNA may persist in the liver (HEPATOLOGY 1993;18:1313–1318.
Tuberculous Lymphadenitis
Authors: P. B. Iles, P. A. Emerson
Journal: BMJ (1974)

A total of 43 episodes of tuberculosis lymphadenitis were treated in 32 adult patients. In 12 instances the affected lymph node was excised without any chemotherapy; there were 10 relapses. The treatment was local excision of the affected lymph nodes together with antituberculosis chemotherapy with at least two drugs in 30 instances; there were no relapses following such therapy.Presumably patients with tuberculosis lymphadenitis are still sometimes treated with surgery alone because that was at one time the orthodox line of surgical teaching. Such a view is out of date: these patients should always be given antituberculosis therapy in addition to any surgical measures.
Correction and Republication: Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

On April 1, 2016, MMWR Surveillance Summaries published "Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years-Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012" (1). On June 5, 2018, the authors informed MMWR about a number of inadvertent errors throughout the report that resulted from reporting of autism spectrum disorder cases among persons who did not live in the geographic surveillance area. Corrections of these errors do not change the interpretation or the conclusions of the original report. In accordance with December 2017 guidance from the International Committee of Medical Journal Editors (2), MMWR has corrected and republished the report (3). The republished report includes the original report with clearly marked corrections in supplementary materials.