tbuckley/cabot-search huggingface dataset:
BILLROTH—SURGEON, TEACHER, MUSICIAN
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Black and White
Authors: Daniel E. Epner
Journal: Annals of Internal Medicine (2013)

On Being a DoctorAugust 20, 2013Black and WhiteDaniel E. Epner, MDDaniel E. Epner, MDFrom MD Anderson Cancer Center, Houston, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-4-201308200-00015 Audio Reading - “Black and White” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Black and White," by D.E. Epner. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Mrs. Connor was a 51-year-old woman with stage IV colon cancer who was referred to our clinical trials unit after receiving extensive salvage chemotherapy. She was hospitalized for hyperbilirubinemia and possible biliary decompression in preparation for trial enrollment. Within seconds of meeting her, I knew that she would not be a candidate for experimental therapy.She was severely cachectic and debilitated, barely able to sit up in bed. Her belly was tensely swollen. An abdominal CT scan revealed extensive ascites and hepatic metastases nearly replacing the liver. I knew that I was about to embark on the heart-wrenching task of ... Author, Article, and Disclosure InformationAffiliations: From MD Anderson Cancer Center, Houston, Texas.Corresponding Author: Daniel E. Epner, MD, Department of Palliative Care and Rehabilitation Medicine, Unit 1414, MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Black and White” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Black and White," by D.E. Epner. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics August 20, 2013Volume 159, Issue 4Page: 304-305KeywordsAscitesBreathingChemotherapyClinical trialsColorectal cancerComputed axial tomographyEnd of life careInflammationLiverMultiple sclerosisQuality of lifeStent implantation ePublished: 20 August 2013 Issue Published: August 20, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hazards of T-Groups
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL PROGRESS.
Journal: JAMA (1887)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Neurology (2020)

Minocycline vs Placebo for Mild Alzheimer Disease 164Alzheimer disease (AD) affects an estimated 50 million people worldwide, but there are no known disease-modifying treatments available.The anti-inflammatory tetracycline antibiotic minocycline inhibits microglia, reduces neuropathology and deficits in transgenic mouse AD models, and is a credible candidate for repurposing in AD modification.In a doubleblind randomized clinical trial including 544 participants with very mild AD based in the UK National Health Service, Howard and coauthors found that 2 years of treatment with the highest tolerable minocycline doses (400 mg/d) gave no benefits on cognitive or functional decline and was poorly tolerated in this population.Despite promising preclinical data, minocycline should not be investigated further as a treatment for symptomatic AD.Editorial perspective is provided by Schneider.
(?) Explained
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aldafermin (NGM282) reduces the cross-linked pro-peptides of type III collagen PRO-C3X, a novel biomarker, in non-alcoholic steatohepatitis and primary sclerosing cholangitis patients
Authors: Stephen Harrison, Lei Ling, James F. Trotter, Angelo Paredes, Andrew Yan, Ulrich Beuers, Gideon Hirschfield, Diana Leeming, Morten Karsdal, Alex DePaoli, Hsiao Lieu
Journal: Journal of Hepatology (2020)
Abstract LB-169: Comprehensive analysis of the expression of eight genes as a prognostic marker in head and neck cancer
Authors: Heuijoon Park, Yuzheng Zhang, Chang Xu, Chu Chen, Pei Wang, Eduardo Méndez
Journal: Cancer Research (2019)

Abstract Head and neck cancer (HNC) is the 6th most common cancer worldwide, and the survival rate of HNC is about 50%. There has been no significant improvement in survival in HNC for over 50 years. Many HNC cases are not identified until an advanced stage. Thus, prevention, early detection, and better treatment are critical factors to reduce morbidity and mortality in HNC. Genome-wide next generation sequencing techniques allow investigation of patient-specific molecular signatures that may provide insight into the design of customized cancer therapies. Our previous studies have identified critical genetic signatures for HNC initiation and progression, and these signatures are strongly associated with progression-free survival (PFS) of HNC patients. To improve current molecular markers, a survival predictive model was built using ElasticNet Cox regression model with different sets of molecular markers (313 unique genes) from our three published studies and TCGA RNAseq expression data (n = 260). Deregulated expression of eight genes (FADD, PPFIA1, RYK, SMARCA2, SNX10, DCAF13, C18orf21 and THBS1) was identified and showed strong association with PFS. This eight-gene prediction model was validated by an independent oral squamous cell carcinoma (OSCC) specific mortality dataset from MD Anderson Cancer Center (n = 71 OSCC, AUC = 0.857). Next, we analyzed the association between deregulated expression of these eight genes and the top 5% (n = 420) most commonly mutated genes in HNCs (n = 260) via pairwise Pearson correlation coefficient with p value. This analysis revealed that deregulated expression of these eight genes is strongly associated with mutations in TP53 and NOTCH1. This result was confirmed by additional analysis with a Regularized Multivariate Regression for Identifying Master Predictors (RemMap) model. Finally, to investigate the association of copy number variation (CNV) with expression of the 8-gene panel, pairwise Pearson correlation with p-value calculation was performed between the copy number data and the expression of the eight genes, and the most correlated regions were identified to be in chromosome arms 3p, 5q, and 11q. Further analysis using only HPV-negative OSCC samples revealed an association of eight-gene deregulation with CNV in 11q13. We conclude that this new eight-gene marker panel is strongly correlated with PFS of HNC patients. Further evaluation using new HNC data sets is thus justified to establish the utility of this new eight-gene panel as a prognostic marker. Citation Format: Heuijoon Park, Yuzheng Zhang, Chang Xu, Chu Chen, Pei Wang, Eduardo Méndez. Comprehensive analysis of the expression of eight genes as a prognostic marker in head and neck cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-169.
Native Borne
Authors: Thomas E. Richtsmeier
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health care technology and the inevitability of resource allocation and rationing decisions. Part II
Authors: R. W. Evans
Journal: JAMA (1983)

<h3>ALLOCATION AND RATIONING OF HEALTH CARE RESOURCES</h3> Of all the resource-shortage crises this nation is expected to confront in the future, the problem of resource distribution is likely to be most acute and problematic in medicine.<sup>23,29,123</sup>Persons will be recognized as in need of, and then denied, benefits that the medical care provision system is capable of providing. Instead of an unidentified mass of persons being denied access to a needed resource, persons whose names have become known to the public will be declared ineligible for a treatment or service they are known to require.<sup>124</sup>Perhaps this scenario is inhumane, but it is undoubtedly a true representation of reality. As already noted, technology now permits to be saved the lives of persons who less than a decade ago would have surely died. Moreover, technology has made it exceedingly difficult to specify at precisely what point life ceases. This
Correction to Medical News Interview
Authors: Johannes Ramaekers, Thomas Arkell, Iain Mcgregor
Journal: JAMA (2021)

emerging interest in CBD as a treatment for alcohol-related health problems. 5While prior research indicates additive impairment and crash risk with low doses of THC and alcohol, 2 we do not expect a similar effect with CBD.A definitive confirmation, however, would be useful.Moreover, with increasingly liberal attitudes toward medical and nonmedical use of cannabis, there is an unmet need to understand factors that moderate the magnitude and duration of THCinduced driving impairment.We agree with Downey and Hayley and Tseng and colleagues that use of additional measures of driving performance, such as driver monitoring systems and measures of visual perception, would also be helpful.Integrated technological solutions offering a holistic index of driver impairment in experimental settings might ultimately become standard in motor vehicles, allowing monitoring and protection of drivers from the crash risks associated with drug and alcohol use.In keeping with our statistical analysis plan, we did not consider the effect of participant characteristics such as sex, age, or cannabis use on our outcome variables, as queried by Dr Singh.Nonetheless, this is a relevant consideration for future work.Long-term cannabis users develop partial tolerance to the impairing effects of THC, 6 a characteristic that is relevant to patients who consume THC daily.Future study designs should thus incorporate moderating factors as independent variables to assess their effect on THC-induced impairment.
Klinische Neuroradiologie
Authors: Thomas C. Parsons
Journal: JAMA (1961)

This symposium on neuroradiology is an ambitious project undertaken by several different medical centers including McGill, Columbia, the University of Munich, and the Massachusetts General Hospital. The first chapters are devoted to the definition of normal signs and the application of special techniques, including air studies, angiograms, and myelograms. Subsequent chapters are devoted to pathological changes as encountered in vascular diseases, epilepsy, brain tumors, neuropsychiatrie disturbances, morbid conditions in children, eye and ear disorders, malformations, and spinal tumors. The text is clear, succinct, and interestingly written. The illustrative material is of superior technical quality. There are two criticisms. First, the illustrations are negatives of the actual roentgenograms, so that appropriate conversions need always be made. Second, in the matter of organization there is inconsistency. As can be seen from the listing above, neither an anatomical nor an etiological classification has been used exclusively. For example, the Sturge-Weber disease, though discussed under vascular disturbances, could equally well be considered under malformations, diseases of children, or, possibly, neuropsychiatrie disturbances. Tuberous
Graduate medical education in the United States, 1984-1985
Authors: A. E. Crowley
Journal: JAMA (1985)

<h3>INTRODUCTION</h3> This annual report on graduate medical education in the United States contains data on number of residency programs by specialty and by region, number of positions offered, number of trainees by specialty and by region, number of foreign medical graduates in each specialty and in each state, and information on the ethnic background and citizenship of trainees. This year's report also includes the results of a two-year Special Survey of programs that accept medical school graduates who have had no previous graduate medical training, ie, programs that offer "postgraduate year-1" (PGY-1) positions. There is information on the institutions and agencies that sponsor graduate medical training programs. Four new subspecialties have been added to the list of accredited programs. In 1984, the Accreditation Council for Graduate Medical Education (ACGME), through the Residency Review Committees, accredited programs for hematology (pathology), neonatal-perinatal medicine, vascular surgery, and programs that combine training in general
British Rainfall
Authors: G. J. Symons
Journal: BMJ (1882)

<h3></h3> For patients with refractory focal epilepsy, surgical resection of the epileptogenic zone can lead to a drastic reduction in seizure frequency. Careful localisation of the epileptogenic zone is imperative in the presurgical workup. Up to 20% patients with refractory focal epilepsy have a normal MRI and are less likely to be referred for epilepsy surgery. As a result, 18-FDG-PET has been employed to localise the epileptogenic focus, which appears as a region of hypometabolism. This study examines the real-world utility of 18-FDG-PET imaging among patients undergoing for presurgical assessments over a 5-year period. Between January 2015 and March 2020, 65/90 patients referred for presurgical assessment underwent 18-FDG PET. In total, 26/65 (40%) patients had corresponding focal abnormalities on 18-FDG PET and MRI studies, of whom 22 had focal epileptiform activity on video-EEG (80.1%). Therefore, where 18-FDG PET and MRI agree, there is a high predictive value for successful seizure localisation with video-EEG moni- toring. Furthermore, 33/65 (40.7%) patients had MRI-negative epilepsy, of whom 17/33 (51.1%) had focal hypometabolism on 18-FDG PET. Thus, over half of our patient cohort with “non-lesional” or MRI-negative epilepsy were able to proceed to intracranial video-EEG monitoring or resective surgery with the help of supportive data from 18-FDG PET imaging.
“Variability of within-breath reactance in COPD patients and its association with dyspnoea.” Bernt B. Aarli, Peter M.A. Calverley, Robert L. Jensen, Tomas M.L. Eagan, Per S. Bakke and Jon A. Hardie.<i>Eur Respir J</i>2015; 45: 625–634.
Authors: Bernt Aarli, Peter Calverley, Robert Jensen, Tomas Eagan, S Bakke
Journal: European Respiratory Journal (2017)

with an error in one sentence of the Methods section, in the subsection entitled "Pulmonary function tests".Originally, the sentence erroneously stated that ΔXrs was calculated as the mean Rrs 5 during inspiration minus the mean Rrs 5 during expiration averaged over the sampling period.The correct sentence reads as follows:"In addition, we report ΔXrs calculated as the mean Xrs 5 during inspiration minus the mean Xrs 5 during expiration averaged over the sampling period, a multiple-breath approach.
Causes of perinatal mortality in the US Collaborative Perinatal Project
Authors: R. L. Naeye
Journal: JAMA (1977)

The underlying causes of 80% of perinatal deaths were identified in a study of 53,518 pregnancies in the United States: 17% of the deaths were due to amniotic fluid infections, 11% to abruptio placentae, 10% to premature rupture of the membranes, 9% to congenital anomalies, 6% to large placental infarcts, and the rest to more than 20 other specific disorders. (<i>JAMA</i>238:228-229, 1977)
Retirement: Be Prepared
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Observations on the Morbid Anatomy, Pathology, and Determining Cause of Emphysema of the Lungs
Authors: A. T. H. Waters
Journal: BMJ (1860)

OOMMUNIOATIONSl (am Xu&JrUAu qainO of an abnomal at&e of the liquor sgainis, may be oount.ratedby thoe approprie rmedy.Enay, none of the liquids mentioned in these expenrments produce any troublin or deposit from the liquor sanguiinis.A moleeular matter, or a red colour appearing, is a proof of the destructiOn of many corpuscles; and the place where the de- struetion has occurred may always be found, unless there be streams flowing fast in the liquid.And it is very necessary, in repeating my experiments, to allow for the effect of these streams.In using the high powers of the microscope, rapidity of manipulation is impossible: the addition of the smallest quantity of an extraneous fluid to a drop of blood destroys some corpuscles, aind alters the form of others, so that by the time the object can be placed in the focus of the objectglass, streams of fresh corpuscles may be flo'ring over the place of the destroyed ones; hence, the extremes between de- struction and no alteration in the corpuscles may, perebance, be brought togethler.The observer must follow out the course of the streams, wlhich frequently give important assistance in the observations.