tbuckley/cabot-search huggingface dataset:
Multiple Antibody Production in Myasthenia Gravis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PATHOLOGY
Authors: Robert D. Coye
Journal: JAMA (1966)

The pathology texts published in the past few years reflect to varying degrees the changes that are evolving in the teaching of pathology. These changes lie in the direction of greater emphasis on the use of biochemical, genetic, physiological, immunologic, and ultrastructural information to explain the basic mechanisms of disease. This kind of information applies more directly to general pathology, or the "basic science" of disease, than to organ pathology, and consequently general pathology has been expanding at the expense of classical descriptive morphology. Thus, describing a text as "modern" or "up-to-date" implies not only inclusion of recent anatomical information but these other insights as well. <h3>"Modern" Approach</h3> A modern approach is well illustrated in Florey's<i>Lectures on General Pathology</i>(ed 3, Saunders, 1962, $22) which has been until recently the only such book available in the field. This is the basis for a "pure" basic science course at Oxford.
DOCTORS DILEMMAS
Journal: CA A Cancer Journal for Clinicians (1954)

Q Considerable diflerence ofopinionexists aiizong our surgical atid gynecologi cal stall on ihe soundest treatment of cer vical â€oe¿ Ca/C laO/na in situ.''7/he literature appears to be somewhat less than utiani F11OUS in its recommendations.Can the mailer be more clearly' delineated at pies ent?
Global <i>BRAF</i> testing practices in metastatic colorectal cancer (mCRC).
Authors: Jayesh Desai, Scott Kopetz, Axel Grothey, Fortunato Ciardiello, Tae Won Kim, Tim Maughan, Eric Van Cutsem, Harpreet Singh Wasan, Rona Yaeger, Takayuki Yoshino, Ashwin Gollerkeri, Michelle L. Edwards, Montessa Rodriguez Lizaso, Josep Tabernero
Journal: Journal of Clinical Oncology (2021)

e15523 Background: The BRAF V600E mutation is a marker of poor prognosis in patients with mCRC. Targeted therapy, such as encorafenib + cetuximab, is approved in the US/Europe for the treatment of BRAF V600E-mutated mCRC and demonstrated improved survival vs historical standard of care (SOC). Determining BRAF mutation status in mCRC is recommended by NCCN and ESMO guidelines; although adherence to these guidelines may not be uniform. This report’s objective is to communicate global survey results of mCRC BRAF testing practices. Identifying regions where BRAF testing is not SOC may help identify where education efforts are needed to improve effective treatment decision making. Methods: Oncology treatment centers were identified from a registry and from public information. Centers were selected for research experience, historic data quality, and estimated numbers of mCRC patients. A BRAF testing practices survey using an online platform of verified centers was conducted from March to November 2020; 425 sites in 39 countries responded. Results: BRAF testing is performed as SOC most commonly in Northern and Western Europe (97%) and East Asia (95%). Conversely, BRAF testing as SOC is least common in Eastern Europe (47%) and South America (52%). Surveyed regions generally test patients when confirming advanced disease prior to first-line (1L) treatment (35% to 78%) or at initial histological diagnosis (9% to 41%). Most regions test tumor tissue; few test both tumor tissue and blood; and none conduct blood mutation testing only. Testing practices in the US by type of site (academic vs community) will be presented. Conclusions: BRAF testing has global variability, impacting treatment decisions. Increased awareness and routine testing may lead to informed decisions regarding targeted therapies, such as encorafenib + cetuximab (where approved), in patients with BRAF V600E-mutant mCRC.[Table: see text]
Seventh Annual Meeting of the Cell Kinetics Society
Journal: JNCI Journal of the National Cancer Institute (1982)

Seventh Annual Meeting of the Cell Kinetics Society Get access JNCI: Journal of the National Cancer Institute, Volume 69, Issue 4, October 1982, Page 987, https://doi.org/10.1093/jnci/69.4.987-e Published: 01 October 1982
Acute Poliomyelitis (Heine-Medin's Disease).
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;TITLE&gt;Violence in the Media&lt;/TITLE&gt;
Journal: JAMA (2000)

and the AMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.
Prostatic Cancer
Authors: SAUL B. GILSON
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 March 1975Prostatic CancerSAUL B. GILSON, M.D., F.A.C.P.SAUL B. GILSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-3-427_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report on the symposium on prostatic cancer (in the editorial section of the October 1974 issue,Annals of Internal Medicine) describes a "goal of improved early detection." If this goal is reached, it will place the clinician in a terrible quandary. Clinical cancer of the prostate is relatively rare. Yet "35% of all men over 50 have microfoci of prostatic cancer" (1). Thus, most of these cases remain safer undiagnosed. It would seem that "ripeness is all" and early intervention ill advised. Indeed, the prevalence of an indefinitely quiescent cancer suggests a need for reevaluation of...Reference1. CRILE G: Management of breast cancer. JAMA 230:95-98, 1974 CrossrefMedlineGoogle Scholar1. WHITNEY W: The natural history of prostatic cancer. Cancer 32:1104-1112, 1973 CrossrefMedlineGoogle Scholar2. BAUERMCGAVRANCARTER WMM: Unsuspected carcinoma of the prostate in suprapubic prostatectomy specimens. Cancer 13:370-378, 1960 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 469 Ft. Washington Avenue New York, New York 10033 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1975Volume 82, Issue 3Page: 427-428KeywordsProstate cancer Issue Published: 1 March 1975 PDF DownloadLoading ...
Dangers of immunosuppressive drugs in ulcerative colitis.
Journal: BMJ (1966)

Labelling of DrugsSIR,-The report of the Committee on Safety of Drugs for 1965 expressed the view that it would conduce greatly to the safe use of drugs if containers of prescribed medicines were labelled with the name of the medicine unless otherwise specified by the doctor.This stimulated a considerable degree of comment in the lay press.The Committee is not alone in advocating this view.Nevertheless, many of your readers may be unaware of how widely it is already shared, and they may be interested, therefore,
New medical schools. Can they be established quickly at less expense?
Authors: K. E. Penrod
Journal: JAMA (1971)

Although I agreed to address myself to this title, I shall take the liberty of complying with the spirit but not the letter. Rather than speak of establishing new medical schools, I prefer to discuss ways of achieving the same ends through different means. The fact that there must be a major expansion of medical education needs no elaboration. Somewhere between 4,000 and 9,000 additional entering places must be made available before the end of the decade to meet the various goals that have been announced. Such demands clearly call for new thinking. Several factors of significance to medical education have appeared recently. The medical curriculum has undergone critical examination and change in most schools. Meanwhile, long overdue educational reforms have been taking place over the entire span from the lower grades through college. While the newer concepts of learning have by no means been universally adopted, many of those
INFLUENZA AND THE DEATH-RATE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Osteoclast: Friend or Foe?
Authors: Deborah V. Novack, Steven L. Teitelbaum
Journal: Annual Review of Pathology Mechanisms of Disease (2007)

Bone is a dynamic organ constantly remodeled to support calcium homeostasis and structural needs. The osteoclast is the cell responsible for removing both the organic and inorganic components of bone. It is derived from hematopoietic progenitors in the macrophage lineage and differentiates in response to the tumor necrosis factor family cytokine receptor activator of NFκB ligand. αvβ3 integrin mediates cell adhesion necessary for polarization and formation of an isolated, acidified resorptive microenvironment. Defects in osteoclast function, whether genetic or iatrogenic, may increase bone mass but lead to poor bone quality and a high fracture risk. Pathological stimulation of osteoclast formation and resorption occurs in postmenopausal osteoporosis, inflammatory arthritis, and metastasis of tumors to bone. In these diseases, osteoclast activity causes bone loss that leads to pain, deformity, and fracture. Thus, osteoclasts are critical for normal bone function, but their activity must be controlled.
In Vivo Metabolism and Genotoxic Effects of Nitrated Polycyclic Aromatic Hydrocarbons
Authors: L. Moller
Journal: Environmental Health Perspectives (1994)

During incomplete combustion of organic matter, nitro-polycyclic aromatic hydrocarbons (nitro-PAHs), are formed in a reaction that is catalyzed by a low pH. 2-Nitrofluorene (NF), a marker for nitro-PAHs, is metabolized in vivo by two different routes.After inhalation, potent mutagenic metabolites, hydroxylated nitrofluorenes (OH-NFs), are formed.The metabolites are distributed by systemic circulation.After oral administration, NF is reduced to the corresponding amine, a reaction mediated by the intestinal microflora.This metabolite is acetylated to 2-acetylaminofluorene (AAF), a potent carcinogen.Further ring-hydroxylation of AAF leads to detoxification and excretion.Induction of cytochrome P450s affects the metabolism, and more OH-NFs are formed.As a consequence, more mutagenic metabolites are found in the circulation.OH-NFs are excreted in the bile as, in terms of mutagenicity, totally harmless glucuronide conjugates.When these conjugates are excreted via the bile, intestinal )-glucuronidase can liberate direct-acting mutagens in the intestine.Thus, inhalation of NF can lead to formation of potent mutagens in the intestine.NF is a direct-acting muta- gen in bacterial assays and an initiator and promoter of the carcinogenic process, and gives rise to DNA adduct formation in laboratory animals.-
Medicine for the Practicing Physician
Authors: John J. Massarelli
Journal: JAMA (1984)

<i>Medicine for the Practicing Physician</i>is a textbook from Emory University School of Medicine in Atlanta. The editor in chief is J. Willis Hurst, MD; there are 29 editors and 88 other contributors. Features that distinguish this book from others in the field include the pragmatic orientation for practicing physicians, the range of coverage that includes sub-specialty areas not usually found in a textbook of medicine, the organization in bite-sized topics, and the possibility of access to information at various levels adaptable to a specific clinical problem. This last is the book's most valuable asset. Dr Hurst suggests that its use will begin with a question about a patient. The level at which the physician enters the book will be determined by his or her level of understanding of the patient's problem. For example, after seeing a patient with a long history of frequent bowel movements and bulky stools, the
<i>Bax</i> Expression Decreases Significantly From Primary Tumor to Metastasis in Colorectal Cancer
Authors: Agneta Jansson, Xiao-Feng Sun
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Bax is a proapoptotic member of the bcl-2 family. Previous studies about Bax have shown that the expression increases from normal to tumor tissue, but the clinical significance is contradictory. Our aims were to analyze the expression of Bax from normal mucosa to primary tumor and to metastases in colorectal cancer patient. We further investigated whether low Bax expression in the primary tumor or changed expression from normal mucosa to primary tumor and to metastases had biologic and clinical significance. PATIENTS AND METHODS: The study included 135 patients with primary colorectal adenocarcinoma, of whom 31 had metastases in the lymph nodes and 75 had normal mucosa. Immunohistochemistry, DNA sequencing, and microsatellite analysis were used to detect Bax expression, mutations, and microsatellite instability. RESULTS: The protein was observed in 132 of 135 tumors, all normal epithelial cells and metastases. The frequencies of weak expression were greater from well/moderately to poorly differentiated and to mucinous carcinomas. Bax expression was stronger from normal to tumor tissue, but subsequently decreased in metastases. The matched cases with lower expression in the metastases than in the primary tumor showed a more infiltrative growth pattern and more distal metastases. CONCLUSION: The association of Bax expression with tumor differentiation/histologic types and a decreased expression in the metastases, suggests that Bax expression may be involved in tumor differentiation/histologic types and metastatic progression. We also propose the novel notion that changed Bax expression in the metastases compared with the primary tumors might provide information to determine the clinicopathologic characteristics of the tumor.
(29) Pemphigus vulgaris
Authors: A E. Walker
Journal: British Journal of Dermatology (1978)

Journal Article (29) Pemphigus vulgaris Get access A E. Walker A E. Walker Royal Hospital, Chesterfield Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue s16, 1 December 1978, Page 60, https://doi.org/10.1111/j.1365-2133.1978.tb15251.x Published: 01 December 1978
Reply
Authors: S.K. Jones, W.C. Campbell, Rona M. MacKie
Journal: British Journal of Dermatology (1986)

Journal Article Reply Get access S.K. Jones, S.K. Jones University Department of Dermatology, Western Infirmary, Glasgow, G11 6NU, U.K. Search for other works by this author on: Oxford Academic Google Scholar W.C. Campbell, W.C. Campbell University Department of Dermatology, Western Infirmary, Glasgow, G11 6NU, U.K. Search for other works by this author on: Oxford Academic Google Scholar Rona M. MacKie Rona M. MacKie University Department of Dermatology, Western Infirmary, Glasgow, G11 6NU, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 114, Issue 4, 1 April 1986, Page 519, https://doi.org/10.1111/j.1365-2133.1986.tb02866.x Published: 01 April 1986
Applied Neurochemistry
Authors: Orville T. Bailey
Journal: JAMA (1969)

This monograph by nine English authors is part of the Contemporary Neurology Series. The title may be somewhat misleading. Its aims are to integrate certain phases of neuroanatomy and neurochemistry and to provide research workers in each field with data in the other, so as to promote further interactions between the two disciplines. The presentation is divided into three sections. The first discusses newer concepts in neuroanatomy and neurochemistry; the second deals with the metabolism of amino acids, lipids, and carbohydrates in nervous tissue. A final section comprises a series of essays on chemical neurobiology in special situations, such as the developing brain, memory mechanisms, mental disease, and heredodegenerative disorders. Excellent printing and clearly reproduced illustrations serve the authors well. The style of writing is clear, literate, and surprisingly uniform for a book with multiple authors. Correlation between knowledge of anatomic structure and neurochemistry is a laudable objective. To achieve
OP 0759-0792
Authors: C Neuhaeuser, K Feuer, V Preiss, M Mueller, S Scholz, I Welters, S Pampori, P Kotos, E Soilemezi, C Adamopoulos, M Tsagourias, D Matamis, K Görlinger, C Jambor, A Hanke, M Adamzik, M Hartmann, N Rahe-Meyer, S Yoon, Y Lee, H Lee, N Gil, J Bahk, Y Jeon, S Jochberger, V Mayr, G Luckner, C Torgersen, W Hasibeder, M Dünser, S Heemskerk, F Van Haren, N Foudraine, W Peters, J Van Der Hoeven, F Russel, R Masereeuw, P Pickkers
Journal: Intensive Care Medicine (2007)
An unusual cause of recurrent chest pain
Authors: D. E. Fixler
Journal: JAMA (1975)

BY FAR the most common cause of pleural effusion in children is pulmonary infection. When infection is excluded as a cause of pleural effusion in a child, an uncommon or even rare cause must be sought. The case reported here was characterized by recurrent episodes of chest pain and pleural effusion. Bacterial infection was not present, and only after extensive studies did it become evident that the pleural effusion was caused by spontaneous drainage of pericardial effusion into the left pleural cavity through a congenital defect in the pericardium. <h3>Report of a Case</h3> A 12-year-old boy was transferred to Children's Medical Center with a four-day history of chest pain and orthopnea. He had not had any recent respiratory infection, fever, or chest trauma. Symptoms similar to current ones had occurred both 36 and 14 months earlier. During the latter illness, the boy had been hospitalized because of massive left pleural
Human T-cell lymphotropic viruses: syncytia formation
Authors: L. Resnick
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis." Jay A. Nadel. Eur Respir J 2013; 42: 1438-1440.
Journal: European Respiratory Journal (2014)

One sentence in the concluding paragraph of this editorial contained an error.The corrected sentence is as follows.An abnormality in the CFTR gene is responsible for CF disease, but the mechanism by which CFTR expression results in the pathological manifestation of CF disease is not clear.''Bronchodilator combinations for COPD: real hopes or a new Pandora's box?''Nicolas Roche and Pascal Chanez.