tbuckley/cabot-search huggingface dataset:
Hemodialysis in the treatment of severe hypercalcemia
Authors: B. S. Strauch
Journal: JAMA (1976)

Severe hypercalcemia is a life-threatening problem that requires prompt therapy. With the exception of diuresis, most forms of therapy are either ineffective, slow in action, or have major serious disadvantages. In some instances diuresis is relatively ineffective. As shown in this case report, hemodialysis with a dialysate low in calcium is rapidly effective in such instances and should be considered for patients with severe hypercalcemia while they are being prepared for surgery or while diagnostic studies are being performed. (<i>JAMA</i>235:1347-1348, 1976)
Incomplete Signature
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adverse reactions to drugs and chemicals. A resume and progress report
Authors: N. S. Irey
Journal: JAMA (1974)

A registry for studying the morphological changes that occur in patients with adverse reactions to drugs was established more than eight years ago. Since then, 2,700 cases have been accessioned. There are major problems in analyzing and diagnosing alleged drug-reaction cases. Consultative, investigative, and educational functions of the registry have been developed. Recognizing the need for correlating the morphological with the clinical and clinical-laboratory findings, the registry has carried out 18 investigations on selected cases. (<i>JAMA</i>230:596-598, 1974)
The Trauma of Birth.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Participants Index
Authors: G Antognoli, K Aoki, M Araie, M Araki, M Armaly, D Armeniades, L Arnell, N Arribas, K Asanagi, P Asbell, P Ashton, J Augsburger, R Augustine, N Avasthi, P Avasthi, E Avetisov, M Avila, K Kaga, K Kairada, M Kaitz, K Kajiwara, R Kalsi, S Kalyanaraman, G Kambara, K Kameyama, Z Kamieniecka, J Kammer, M Kamoun, S Kanagami, J Kanakis, M Kaneko, K Kani, R Kapahtia, F Kapetansky, I Kaplan, A Kapoor, J Karesh, E Karp, H Kasai, K Kashima, P Kastl, M Kato, Y Katsume, M Kay, K Kazuhisa, T Kearns, R Keates, A Keeney
Journal: Ophthalmology (1982)
OVARIOTOMY.
Authors: None H.
Journal: JAMA (1884)

Dec. 1, 1884. To the Editor of the Journal of the American Medical Association. I have been much interested in the article entitled, " Unilocular Ovarian Cyst Weighing 95 pounds Successfully Removed, by Geo. E. Ranney,m.d., of Lansing, Mich." I was not alone interested in the history of the case, from the great size of the tumor, but more especially from the fact that about one month ago the same case was reported, in the<i>Medical Age</i>, of Detroit, as being " the largest ovarian tumor ever removed in the State of Michigan," and that Dr. Edward W. Jenks, of Detroit, was the remover thereof, and that Dr. Ranney "assisted." As Dr. Ranney did not furnish this information to the<i>Age</i>, I am much interested in the<i>how</i>and the<i>whatfor</i>of this dual report? Did this patient really have two 95-pound tumors? so that Dr. Jenks could cut away. one,
A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction
Authors: Luciani R. Carvalho, Kathryn S. Woods, Berenice B. Mendonca, Nathalie Marcal, Andrea L. Zamparini, Stefano Stifani, Joshua M. Brickman, Ivo J.P. Arnhold, Mehul T. Dattani
Journal: Journal of Clinical Investigation (2003)

The paired-like homeobox gene expressed in embryonic stem cells Hesx1/HESX1 encodes a developmental repressor and is expressed in early development in a region fated to form the forebrain, with subsequent localization to Rathke’s pouch, the primordium of the anterior pituitary gland. Mutations within the gene have been associated with septo-optic dysplasia, a constellation of phenotypes including eye, forebrain, and pituitary abnormalities, or milder degrees of hypopituitarism. We identified a novel homozygous nonconservative missense mutation (I26T) in the critical Engrailed homology repressor domain (eh1) of HESX1, the first, to our knowledge, to be described in humans, in a girl with evolving combined pituitary hormone deficiency born to consanguineous parents. Neuroimaging revealed a thin pituitary stalk with anterior pituitary hypoplasia and an ectopic posterior pituitary, but no midline or optic nerve abnormalities. This I26T mutation did not affect the DNA-binding ability of HESX1 but led to an impaired ability to recruit the mammalian Groucho homolog/Transducin-like enhancer of split-1 (Gro/TLE1), a crucial corepressor for HESX1, thereby leading to partial loss of repression. Thus, the novel pituitary phenotype highlighted here appears to be a specific consequence of the inability of HESX1 to recruit Groucho-related corepressors, suggesting that other molecular mechanisms govern HESX1 function in the forebrain.
The Practitioners' Visiting List for 1907. A pocket-sized book containing memoranda and important data, and ruled blanks for recording the details of practice.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract Title
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stake Poles
Authors: Amy Ship
Journal: Annals of Internal Medicine (2016)

Ad Libitum19 April 2016Stake PolesAmy Ship, MDAmy Ship, MDFrom Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-2010 Audio Reading - “Stake Poles” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Stake Poles," by A.N. Ship. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail After the first of my threeyoung sons died,I felt as if the foundationsin my life were unstable,the stake poles tenuous.After the second of my threeyoung sons died,I lost faith in the capacityof the foundations to hold.I couldn't imagine how stake polescould supportany structure.So, when we took my last sonto the circusthree months after his brother's deathand he cried with fearmostly of the clowns,I, too, became scared.Scared that the circus'stake poles wouldn't hold,scared of all the invisible forcesthat might sweep him away from me,as his brothers had been.and when we left ... Author, Article, and Disclosure InformationAffiliations: From Boston, Massachusetts.Current Author Address: Amy N. Ship, MD, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215; e-mail, [email protected]harvard.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Stake Poles” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Stake Poles," by A.N. Ship. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 19 April 2016Volume 164, Issue 8Page: 568KeywordsFearStorms ePublished: 19 April 2016 Issue Published: 19 April 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Presse Médicale,
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Least Severe Flu Season in 3 Years
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
213O Nintedanib + pemetrexed/cisplatin in malignant pleural mesothelioma (MPM): Phase II biomarker data from the LUME Meso study
Authors: N. Pavlakis, F. Grosso, N. Steele, A. Nowak, S. Novello, S. Popat, L. Greillier, M. Reck, T. Kitzing, G. Scagliotti
Journal: Journal of Thoracic Oncology (2018)
Abstract P117: A Mathematical and Physical Model for Non-Pulmonary Oxygenation for Resuscitation Utilizing Solid Peroxides
Authors: Gurbhagat Sandhu, Gary Huvard, Kevin Ward
Journal: Circulation (2008)

Introduction ; Adequate tissue oxygenation is vital for resuscitation. Intravascular O 2 carrying compounds may enhance tissue O 2 delivery under ischemic conditions but use of both hemoglobin and nonhemoglobin O 2 carriers have limitations. Use of compounds capable of producing O 2 at the tissue level may be useful. Solid peroxides such as percarbamide may provide novel means of tissue O 2 delivery since they contain stored O 2 which can be released upon activation with catalase. However, the chemistry is complex and a product must be designed for controlled O 2 production. Objectives : To develop and use a mathematical and physical model to examine the feasibility of creating encapsulated solid peroxides for intravenous O 2 delivery. Methods : An O 2 delivery vehicle combining percarbamide, a non-aqueous liquid carrier, and a biodegradable-compatible polymer coating was developed for controlled O 2 production. Upon contact with plasma, water diffuses across the polymer coating to cause release of H 2 O 2 from percarbamide. The H 2 O 2 then diffuses back across the membrane into plasma reacting with the blood enzyme catalase to form O 2 and water. A permeation cell system was constructed to validate the physical chemistry of this controlled O 2 production approach. A mathematical model incorporating Fickian diffusion and shrinking surface kinetics was derived to model O 2 production. Results : The permeation cell experiments validated the physical chemistry approach of delivering O 2 using encapsulated percarbamide. The mathematical model successfully predicted O 2 release. Experimental and modeling results show that by tuning the coating thickness, coating type, non-aqueous carrier liquid, and solid peroxide size, the rate of O 2 production can be precisely controlled. Percarbamide (150 gms) would produce 250 cc/min of O 2 for 60 minutes to meet whole body metabolic demands. Conclusions : A mathematical and physical model of O 2 production was successfully created allowing manipulation of multiple variables related to releasing O 2 from a solid peroxide delivery system. Experimental results validate the model’s accuracy. This work suggests the feasibility of using encapsulated solid peroxides to produce life sustaining amounts of O 2 for intravenous tissue oxygenation.
Infectious diseases report calls for global control
Authors: C. Marwick
Journal: JAMA (1995)

WHILE<i>The Hot Zone</i>, a book recounting an outbreak of Ebola virus infection among monkeys in a laboratory near Washington, DC, has hit the best seller lists and the public recently followed with anxiety the course of an outbreak of Ebola virus among humans in Zaire, a government group has just turned out a report that declares that the United States is severely limited in its ability to detect and respond to just such disease outbreaks, whether here or in foreign countries. The report,<i>Emerging and Re-emerging Infectious Diseases</i>, highlights the need for setting up some system of disease surveillance and control so that outbreaks like the one in Zaire are recognized early enough to institute control measures. "At the present time, a formal system of disease surveillance does not exist on a global scale," the report states. The report was prepared by an interagency government working group convened by
Clindamycin and diarrhea
Authors: G. D. Friedman
Journal: JAMA (1976)

Of 298 outpatients receiving clindamycin for a variety of indications, diarrhea developed in ten (3.4%); none were diagnosed as having pseudomembranous colitis. This is well within the range of relative frequencies of diarrhea development (0% to 22.2%) reported in 45 previous studies. Reliance solely on computer-recorded instances of diarrhea yielded a substantial underestimate of diarrhea occurrence, but the rate was still significantly higher (<i>P</i>&lt;.05) in clindamycin users than in nonusers. (<i>JAMA</i>236:2498-2500, 1976)
Utility of the Prostate-specific Antigen Test
Authors: Jack Froom
Journal: Annals of Internal Medicine (1994)

Letters15 June 1994Utility of the Prostate-specific Antigen TestJack Froom, MD, Paul Froom, MD, and Mignon Benjamin, MDJack Froom, MDState University of New York at Stony Brook; Stony Brook, NY 11794Sackler School of Medicine; Tel Aviv, IsraelDuke University Hospital; Durham, NC 27710Search for more papers by this author, Paul Froom, MDState University of New York at Stony Brook; Stony Brook, NY 11794Sackler School of Medicine; Tel Aviv, IsraelDuke University Hospital; Durham, NC 27710Search for more papers by this author, and Mignon Benjamin, MDState University of New York at Stony Brook; Stony Brook, NY 11794Sackler School of Medicine; Tel Aviv, IsraelDuke University Hospital; Durham, NC 27710Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-12-199406150-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In his editorial [1] commenting on an article on prostate cancer screening [2], Walsh presents evidence that favors surgical therapy for clinically localized carcinoma of the prostate to that of observation and follow-up. To support his position, he cites an “analysis of palpable, clinical localized prostate cancer” by Adolfsson and colleagues [3] in which “the development of metastases and death from prostatic cancer was 50% lower in men who underwent radical prostatectomy than in those followed expectantly” [1]. Without accompanying absolute rates, a relative risk reduction (even 50%) does not convey the full extent of a putative ...References1. Walsh PC. Using prostate-specific antigen to diagnose prostate cancer: sailing in uncharted waters (Editorial). Ann Intern Med. 1993; 119:948-9. Google Scholar2. Kramer BS, Brown ML, Prorok PC, Potosky AL, Gohagan JK. Prostate cancer screening: what we know and what we need to know. Ann Intern Med. 1993; 119:914-23. Google Scholar3. Adolfsson J, Steineck G, Whitmore WF Jr. Recent results of management of palpable clinically localized prostate cancer. Cancer. 1993; 72:310-22. Google Scholar4. Froom J, Froom P. Prudence in disease prevention. J Clin Epidemiol. 1991; 11:1127-30. Google Scholar Author, Article, and Disclosure InformationAffiliations: State University of New York at Stony Brook; Stony Brook, NY 11794Sackler School of Medicine; Tel Aviv, IsraelDuke University Hospital; Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1994Volume 120, Issue 12Page: 1053-1054KeywordsAntigensCancer screeningCancer treatmentMortalityPatientsProstate cancerRadiation therapyRadical prostatectomyRelative risk Issue Published: 15 June 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Intradermal Immunization
Authors: Seymour Fisher
Journal: JAMA (1967)

<h3>To the Editor:—</h3> In two separate letters (<b>199</b>:282, 1967) Drs. Paul E. Klein and Arthur F. Greenwald recount problems of reactions to administration of tetanus toxoid and of influenza vaccine. Dr. Klein warns against administration of tetanus toxoid to an individual known to be hypersensitive, and Dr. Greenwald advises multiple small doses of influenza vaccine. I strongly urge intradermal inoculations in both instances. The protection given by this method of administration is adequate, and reactions are either mild or local. Frequently they are absent altogether.
Courbe d’apprentissage de l’Endomicroscopie Volumétrique par Laser au cours de l’Endobrachyœsophage
Journal: Endoscopy (2018)

L’endomicroscopie volumétrique par laser (EVL) est une technique de développement récent dérivée de la tomographie par cohérence optique (TCO). Cette technique a pour but d’analyser en temps réel la muqueuse et la sous-muqueuse œsophagiennes sur une profondeur de 3 mm sur 360°. L’EVL permet une analyse de 6 cm d’œsophage en 90 secondes. L’objectif de cette technique est d’identifier avec précision au sein de l’endobrachyœsophage (EBO) des zones dysplasiques dont les caractéristiques endomicroscopiques ont été définies lors de travaux antérieurs.