tbuckley/cabot-search huggingface dataset:
Headache.—Menthol.
Journal: JAMA (1884)

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Erratum: Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC
Authors: T Holien, T K Våtsveen, H Hella, C Rampa, G Brede, L A G Grøseth, M Rekvig, M Børset, T Standal, A Waage, A Sundan
Journal: Leukemia (2012)
From the NIH
Authors: James B. Wyngaarden
Journal: JAMA (1986)

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Beware, the Sporothrix
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response to comment on “Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis”
Authors: Carmelo Carmona-Rivera, Kevin L. Bicker, Paul R. Thompson, Jane H. Buckner, William H. Robinson, David A. Fox, Mariana J. Kaplan
Journal: Science Immunology (2018)

The citrullinome cargo in neutrophil extracellular traps varies according to disease condition and stimulation conditions.
Picswitch
Journal: JAMA (1971)

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<i>QuickStats</i>: Percentage* of Adults Aged ≥20 Years Who Reported Being Told by a Doctor or Health Professional to Increase Their Physical Activity,† by Age Group and Obesity Status§ — National Health and Nutrition Examination Survey, United States, 2011–2014
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

During 2011-2014, 33.2% of adults aged ≥20 years reported that a doctor or health professional told them to increase their physical activity. More than half (52.2%) of adults aged ≥20 years with obesity reported that a doctor or health professional told them to increase their physical activity compared with less than a quarter (22.3%) of adults without obesity. This pattern remained the same for all age groups examined. For both adults with and without obesity, the proportion who reported being told to increase their physical activity increased with age.
Abstract 2543: Cyclin-dependent kinase 1(CDK1)-mediated phosphorylation of SET in mitosis inhibits its oncogenic activity
Authors: Ling Yin, Yongji Zeng, Jixin Dong
Journal: Cancer Research (2019)

Abstract SET is a protein phosphatase 2A (PP2A) inhibitor and functions as an oncogene in multiple human cancer types. Here we revealed a novel phosphorylation site of SET in mitosis and its biological significance in tumorigenesis. We found that the mitotic kinase cyclin-dependent kinase 1 (CDK1) phosphorylates SET in vitroand in vivo at serine 7 during antimitotic drug-induced G2/M phase arrest and in normal mitosis. SET deletion resulted in massive mitotic defects including centrosome amplification, multipolar spindles, and chromosome missregregation. Moreover, we revealed that SET mitotic phosphorylation is required for proper mitotic progression and its oncogenic function in vitro and in xenograft animal models. Furthermore, we found STAT3 and p53 signaling are regulated by SET. Collectively, our findings suggest a novel layer of regulation for SET in mitosis and its role in tumorigenesis. (This is supported by Fred and Pamela Buffett Cancer Center Support Grant P30 CA036727) Citation Format: Ling Yin, Yongji Zeng, Jixin Dong. Cyclin-dependent kinase 1(CDK1)-mediated phosphorylation of SET in mitosis inhibits its oncogenic activity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2543.
Assessment of histologic examination of samples obtained by trans-venous liver biopsy (TVLB) for the diagnosis of acute rejection after liver transplantation F. Durand1, C. Degott2, D. Lebrec1, A. Gadano1 J. Bernuau1, A. Sauvannet3, J. Belghiti3, S. Erlinger1. Service d'H�patologie1, Service d'Anatomie Pathologique2 and, Service de Chirurgie Digestive3, H�pital Beaujon and INSERM U24, Clichy, France
Journal: Hepatology (1995)
BUENOS AIRES
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conflict of interest dilemmas in biomedical research
Authors: M. D. Witt
Journal: JAMA (1994)

BIOMEDICAL researchers in medical centers, universities, and other nonprofit research institutions routinely collaborate with for-profit companies on research. These academic-industry collaborations have generated lifesaving new products, as well as profits for the companies and the researchers. Because of the beneficial effect of biomedical technology transfers on the United States' competitiveness and public health, Congress has made a national priority of bringing academia and industry together.<sup>1,2</sup>However, the industry-academia collaborations have their costs. They create conflicts between the researcher's (and possibly the institution's) academic interests and financial interests. These conflicts of interest threaten the objectivity of science, the integrity of scientists and institutions, and the safety of medical products. At the present time, federal employees working in federal laboratories are constrained by numerous conflict of interest restrictions.<sup>3,4</sup>Researchers outside the federal government, however, are subject to minimal restrictions, even if they receive federal funds. This article examines the existing
Highlights From the <i>Circulation</i> Family of Journals
Authors: Zhenjiang Yang, Joseph Prinsen, Kevin Bersell, Wangzhen Shen, Liudmila Yermalitskaya, Tatiana Sidorova, Paula Luis, Lynn Hall, Wei Zhang, Liping Du, Ginger Milne, Patrick Tucker, Alfred George, Courtney Campbell, Robert Pickett, Christian Shaffer, Nagesh Chopra, Tao Yang, Bjorn Knollmann, Dan Roden, Katherine Murray, Dana Fourey, Melanie Care, Katherine Siminovitch, Adaya Weissler-Snir, Waseem Hindieh, Raymond Chan, Michael Gollob, Harry Rakowski, Arnon Adler, Philipp Lurz, Maximilian Von Roeder, Karl-Philipp Rommel, Johannes Kowallick, Stephan Blazek, Christian Besler, Karl Fengler, Joachim Lotz, Gerd Hasenfuß, Christian Lücke, Matthias Gutberlet, Gerhard Schuler, Andreas Schuster, Jacob Lønborg, Khurram Nasir
Journal: Circulation (2017)

BACKGROUND:The widely used macrolide antibiotic azithromycin increases risk of cardiovascular and sudden cardiac death, although the underlying mechanisms are unclear.Case reports, including the one we document here, demonstrate that azithromycin can cause rapid, polymorphic ventricular tachycardia in the absence of QT prolongation, indicating a novel proarrhythmic syndrome.We investigated the electrophysiological effects of azithromycin in vivo and in vitro using mice, cardiomyocytes, and human ion channels heterologously expressed in human embryonic kidney (HEK 293) and Chinese hamster ovary (CHO) cells. METHODS AND RESULTS:In conscious telemetered mice, acute intraperitoneal and oral administration of azithromycin caused effects consistent with multi-ion channel block, with significant sinus slowing and increased PR, QRS, QT, and QTc intervals, as seen with azithromycin overdose.Similarly, in HL-1 cardiomyocytes, the drug slowed sinus automaticity, reduced phase 0 upstroke slope, and prolonged action potential duration.Acute exposure to azithromycin reduced peak SCN5A currents in HEK cells (IC 50 =110±3 μmol/L) and Na + current in mouse ventricular myocytes.However, with chronic (24 hour) exposure, azithromycin caused a ≈2-fold increase in both peak and late SCN5A currents, with findings confirmed for I Na in cardiomyocytes.Mild block occurred for K + currents representing I Kr (CHO cells expressing hERG; IC 50 =219±21 μmol/L) and I Ks (CHO cells expressing KCNQ1+KCNE1; IC 50 =184±12 μmol/L), whereas azithromycin suppressed L-type Ca ++ currents (rabbit ventricular myocytes, IC 50 =66.5±4μmol/L) and I K1 (HEK cells expressing Kir2.1, IC 50 =44±3 μmol/L). CONCLUSIONS:Chronic exposure to azithromycin increases cardiac Na + current to promote intracellular Na + loading, providing a potential mechanistic basis for the novel form of proarrhythmia seen with this macrolide antibiotic.
Microsatellite Instability
Authors: Albert de la Chapelle
Journal: New England Journal of Medicine (2003)

Microsatellites are stretches of DNA in which a short motif (usually one to five nucleotides long) is repeated several times. A typical mononucleotide-repeat microsatellite might be, for instance, a stretch of 13 adenines, abbreviated (A)13. The most common microsatellite in humans is a dinucleotide repeat of cytosine and adenine, (CA)n, which occurs in tens of thousands of locations in our germ line. Trinucleotide repeats are prone to expansion in meiosis, and when abnormally expanded they lead to a variety of neurologic disorders (such as Huntington's disease, the best known of these) and fragile chromosomal sites (such . . .
Abstract 1382: AlbuBNP (Cardeva), a Novel Recombinant Human B-Type Natriuretic Peptide Serum Albumin Fusion Protein Has Prolonged Renal Enhancing Properties When Compared to Human BNP.
Authors: Horng H Chen, Fernando L Matrin, Alessandro Cataliotti, John A Schirger, John C Burnett
Journal: Circulation (2007)

BACKGROUND: AlbuBNP is a novel recombinant human BNP serum albumin fusion protein which possesses a significantly longer elimination half-life compared to BNP. To date, it remains unclear if this novel protein which represents a single molecule of BNP synthesized with the carrier protein albumin can enter the post glomerular/tubular system due to the fusion of BNP to albumin and mediate renal actions. We hypothesized that this fusion protein will have potent renal actions and possess prolonged renal hemodynamic enhancing and excretory properties based upon its unique structure as compared to native BNP. METHODS: We compared the cardiorenal and humoral actions of intravenous(IV) bolus of administration of AlbuBNP (Cardeva, CoGenesys, Rockville MD) (5 mg/kg, n=7) and Human BNP (Phoenix Pharmaceutical, Belmont CA) (25 μ g/Kg, n=5) in two groups of normal anesthetized dogs. * p&lt;0.05 RESULTS: Single IV bolus of AlbuBNP resulted in a sustained increase in plasma cGMP (5±1 to 9±2 pmol/ml*) and urinary cGMP excretion (1136±113 to 2556±417 pmol/min*), markers of the biological activity of BNP, which remained elevated at the termination of the experiment at 270 minutes. In contrast, with human BNP, both plasma and urinary cGMP peaked at 30 minutes and returned to baseline by 150 minutes. In a similar fashion, there was a sustained increase in natriuresis (39±12 to 159±38 μEq/min*), diuresis (0.2±0.1 to 1.1±0.3 ml/min*), renal blood flow (220±22 to 301±33 ml/min*), and glomerular filtration rate (34±2 to 62±13 ml/min*) with AlbuBNP while with human BNP, these renal effects peaked at 30 minutes and returned to baseline by 150 minutes. Furthermore, there was a gradual and sustained suppression of plasma aldosterone (7.8±2 to 3.6±1 ng/dL*) with AlbuBNP. Likewise, there was a more sustained reduction of cardiac filling pressures with AlbuBNP as compared to human BNP. CONCLUSION: We report for the first time that this newly developed BNP/albumin fusion protein has a more prolonged and sustained renal enhancing properties compared to human BNP. Thus, AlbuBNP (Cardeva) represents a novel long-acting renal enhancing and aldosterone suppressing drug which has therapeutic potential for the management of cardiovascular and renal diseases that should be defined in further studies.
Identification of Persons with Cardiorespiratory Conditions Who Are at Risk of Dying from the Acute Effects of Ambient Air Particles
Authors: Mark S. Goldberg, Richard T. Burnett, John C. Bailar, Robyn Tamblyn, Pierre Ernst, Kenneth Flegel, Jeffrey Brook, Yvette Bonvalot, Ravinder Singh, Marie-France Valois, Renaud Vincent
Journal: Environmental Health Perspectives (2001)

This study was undertaken to identify subgroups of the population susceptible to the effects of ambient air particles.Fixed-site air pollution monitors in Montreal, Quebec, Canada, provided daily mean levels of various measures of particulates and gaseous pollutants.Total sulfates were also measured daily (1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993) at a monitoring station 150 km southeast of the city (Sutton, Quebec, Canada).We used coefficient of haze (COH), extinction coefficient, and Sutton sulfates to predict fine particles and sulfates from a fine particles model for days that were missing.We used the universal Quebec medicare system to obtain billings and prescriptions for each Montreal resident who died in the city from 1984 to 1993.These data were then used to define cardiovascular and respiratory conditions that subjects had before death.Using standard Poisson regression time-series analyses, we estimated the association between daily nonaccidental mortality and daily concentrations of particles in the ambient air among persons with cardiovascular and respiratory conditions diagnosed before death.We found no persuasive evidence that daily mortality increased when ambient air particles were elevated for subgroups of persons with chronic upper respiratory diseases, airways disease, cerebrovascular diseases, acute coronary artery disease, and hypertension.However, we found that daily mortality increased linearly as concentrations of particles increased for persons who had acute lower respiratory diseases, chronic coronary artery diseases (especially in the elderly), and congestive heart failure.For this latter set of conditions, the mean percent increase in daily mortality (MPC) for an increase in the COH across its interquartile range (18.5 COH units per 327.8 linear meters), averaged over the day of death and the 2 preceding days, was MPC = 5.09% [95% confidence interval (CI) 2.47-7.79%],MPC = 2.62 (95% CI 0.53-4.75%),and MPC = 4.99 (95% CI 2.44-7.60%),respectively.Adjustments for gaseous pollutants generally attenuated these associations, although the general pattern of increased daily mortality remained.In addition, there appeared to be a stronger association in the summer season.The positive associations found for persons who had acute lower respiratory diseases and congestive heart failure are consistent with some prevailing hypotheses and may also be consistent with recent toxicologic data implicating endothelins.Further epidemiologic studies are required to confirm these findings.
Leads from the MMWR. Prevention of perinatal transmission of hepatitis B virus: prenatal screening of all pregnant women for hepatitis B surface antigen
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reports and Analyses and Descriptions of New Inventions, in Medicine, Surgery, Dietetics, and the Allied Sciences
Journal: BMJ (1888)

Darwinian point of view, but also in accordance with the princi- ples of Herbert Spencer.The headings of the chapters alone show how wide a field the author hias attempted to cover, for, after discussing the fundamental features of evolution, he con- siders it in its relation to patlhology, comparativieb pathlology, tilet science of ethics, and to rational politics.The book is wortlh of perusal, for it contains much good and suggestive matter, clearly and pleasantly arranged; and undoubtedly represents, as the autlior tells us in llis preface., the result of a great deal of thiinkins; and to this, we may add, careful and diligent study of the principles underlying the tlheory of evolution.
MILK VS. WINE
Journal: JAMA (1933)

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Every doctor has a duty to report suspected child abuse or neglect, says GMC
Authors: Clare Dyer
Journal: BMJ (2012)

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