tbuckley/cabot-search huggingface dataset:
Plastic Surgery at the New York Hospital One Hundred Years Ago with Biographical Notes on Gurdon Buck.
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of hepatocellular carcinoma with combined suppression and inhibition of sex hormones: A randomized, controlled trial*1, *2
Authors: E MANESIS
Journal: Hepatology (1995)

We tested the hypothesis that a combination of sex hormone suppression and inhibition of their target receptors might improve survival for patients with hepatocellular carcinoma (HCC). Eighty-five consequent, previously untreated HCC patients with inoperable disease, were randomized to receive the luteinizing hormone-releasing hormone (LR-RH)-analogue triptorelin and the antiestrogen tamoxifen (33 patients) or triptorelin plus the antiandrogen flutamide (23 patients), or only placebo (29 patients) in a double blind fashion. All groups were comparable as to age, sex, tumor extension, underlying cirrhosis and biochemical parameters. The tamoxifen (TMX) group had a significantly longer survival (282 days) compared with flutamide (112 days) and with placebo (127 days) groups (P = .0238, log rank test). The upper quartile of patients in the TMX group lived 384 days or longer, and most of them (57.1%) were women (P < .0005), in contrast to the upper quartile of the placebo (170 days, 16.7% women) and the flutamide group (134 days, 33.3% women). The calculated tumor volume doubling time (TVDT) was significantly higher in the TMX group (296 days) than in the other two groups (99 and 101 days for placebo and flutamide groups, respectively, (P = .023). In a Cox proportional hazards model, the TMX treatment, along with the baseline Okuda's HCC stage, the hepatitis B surface antigen, the portal vein diameter, the carcino embryonic antigen (CEA) and a self-assessment score of quality of life, were covariates predicting survival. Although the degree of serum sex hormone suppression was not a significant predictor of survival, the interaction of female sex and TMX treatment, it was (P = .0052). We conclude that TMX treatment significantly prolongs survival and the TVDT in unresectable HCC. The effect is most pronounced in female patients and is unrelated to sex hormone suppression.
Kennedy Institute of Ethics Journal
Authors: Gary D. Byrd
Journal: JAMA (1993)

<b>CQ: Cambridge Quarterly of Healthcare Ethics: The International Journal for Healthcare Ethics Committees</b>, David C. Thomasma, Thomasine Kushner, and Steve Heilig, editors, quarterly, $42 (personal), $84 (institutional), New York, NY, Cambridge University Press, winter 1992-. The field of bioethics and health care ethics, like most other biomedical disciplines, has grown rapidly over the past 15 to 20 years. This is clearly evidenced by the rapid growth of the literature. The most recent Kennedy Institute Scope Note on "Basic Resources in Bioethics" (published in the first issue of the<i>Kennedy Institute of Ethics Journal</i>) lists 14 core bioethics journals, not including the two reviewed here. These titles include well-established and highly respected journals like the<i>Hastings Center Report, American Journal of Law and Medicine, Journal of Clinical Ethics, and Linacre Quarterly</i>. Reviews of two other excellent new journals in this field appeared in<i>JAMA</i>during the past year.<sup>1,2</sup> Thus, with
THE PROTECTION OF THE BODY AGAINST ITS OWN DIGESTIVE FERMENTS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Mina Komuta, Tania Roskams
Journal: Hepatology (2012)

We thank Drs. Cardinale et al.1 for the interest in our study.2 In our study, we focused on the "histopathological diversity" in intrahepatic cholangiocellular carcinomas (ICCs). We compared the different tumor types with the different cells lining the biliary tree as possible cells of origin; pure mucin-producing ICC (muc-ICC) can originate from mucin-producing cholangiocytes lining large bile duct versus ICC with histological diversity (mixed-ICC) can originate from the most peripheral biliary branches including hepatic progenitor cells (HPCs), which are capable of differentiating into either hepatocytes or cholangiocytes. As cancer is in general a monoclonal entity, we conclude that recognizing histopathological diversity in ICC could be a sign of HPC-derived ICCs. Therefore, we completely agree with the comment concerning HPCs-derived tumors. However, concerning muc-ICCs, we did not investigate the correlation between muc-ICCs and peribiliary glands (PBGs), and the possible origin of the intraductal papillary neoplasm of the bile duct. To clarify these issues, further studies in a larger series of tumors are required. Therefore, we invite the authors to investigate this hypothesis further in a collaborative effort. Mina Komuta M.D., Ph.D.*, Tania Roskams M.D., Ph.D.*, * Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium.
Effects of Hepatitis C Virus Infection on Genetic Material and on Manifestations of a Related Blood Disease
Journal: Annals of Internal Medicine (2002)

Summaries for Patients1 October 2002Effects of Hepatitis C Virus Infection on Genetic Material and on Manifestations of a Related Blood DiseaseSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-7-200210010-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?When many symptoms and laboratory findings occur together without a specific known cause, the grouping is called a “syndrome.” Mixed cryoglobulinemia (MC) is a syndrome characterized by bleeding spots under the skin, weakness, painful joints, and specific abnormalities in one or more organs of the body. A distinguishing feature of MC is the presence of more than the normal number of B lymphocytes (a white blood cell that makes proteins, known as immunoglobulins, that protect us from infection). MC occurs frequently in people infected with hepatitis C virus ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Prevalence of bcl-2 Rearrangement in Patients with Hepatitis C Virus–Related Mixed Cryoglobulinemia with or without B-Cell Lymphomas.” It is in the 1 October 2002 issue of Annals of Internal Medicine (volume 137, pages 571-580). The authors are AL Zignego, C Ferri, F Giannelli, C Giannini, P Caini, M Monti, ME Marrocchi, E Di Pietro, G La Villa, G Laffi, and P Gentilini.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPrevalence of bcl-2 Rearrangement in Patients with Hepatitis C Virus–Related Mixed Cryoglobulinemia with or without B-Cell Lymphomas Anna Linda Zignego , Clodoveo Ferri , Francesca Giannelli , Carlo Giannini , Patrizio Caini , Monica Monti , Maria Eugenia Marrocchi , Elena Di Pietro , Giorgio La Villa , Giacomo Laffi , and Paolo Gentilini Metrics 1 October 2002Volume 137, Issue 7Page: I-32KeywordsAntiviral therapyBloodCellsGenetic diseasesGeneticsHepatitis C virusInfectious diseasesLymphocytesLymphomaWhite blood cells ePublished: 1 October 2002 Issue Published: 1 October 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Integrin alphaVbeta1 inhibition ameliorates liver fibrosis in mice
Authors: Richard Chen, Parmita Saxena, Mayra Senices, Vinod Yadav, Bryce Harrison, James E. Dowling, Patrycja Nowakowski, Laura Cappellucci, Faith Finley, Andrew Sullivan, Angela Kennedy-Curran, Terence Moy, Albert Lin, Dan Cui, Adrian Ray, Blaise Lippa, Alex Lugovskoy, Bruce Rogers, Liangsu Wang, Min Lu
Journal: Journal of Hepatology (2020)
Officials of the Association
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of ethylene glycol poisoning with ethyl alcohol
Authors: W. E. Wacker
Journal: JAMA (1965)

In the course of phylogenetic evolution, the substrate specificity of alcohol dehydrogenase, the enzyme which detoxicates ethyl alcohol, has apparently broadened. Thus, while the enzyme from yeast oxidizes ethyl alcohol and only a few other alcohols,<sup>1</sup>the enzyme of the horse liver is capable of oxidizing a range of other alcohols.<sup>1,2</sup>The human enzyme has an even wider range,<sup>3</sup>since contrary to the horse enzyme it oxidizes both ethyl alcohol and ethylene glycol. While chemically ethylene glycol is very similar to ethyl alcohol, both these compounds are toxic to man. Detailed studies of the enzymatic oxidation of ethylene glycol demonstrate that ethyl alcohol, the natural substrate, is a potent competitive inhibitor of the oxidation of ethylene glycol.<sup>3</sup>Hence, low concentrations of ethyl alcohol prevent the oxidation of large concentrations of ethylene glycol. These biochemical features of the catalytic behavior of human-liver alcohol dehydrogenase have served as
MICHIGAN FALLS INTO LINE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1615: Correlation between demographic factors, dietary habits and urinary micronutrient content among minority groups in New York City
Authors: Cristina Zambrano, Maayan Beeber, April Panitz, Katarzyna Wyka, Safa Ibrahim, Yin Tan, Grace Ma, Khursheed Navder, Ming-Chin Yeh, Olorunseun Ogunwobi
Journal: Cancer Research (2019)

Abstract Cancer is the second leading cause of death in the United States. A diet low in fruits and vegetables increases the risk of certain cancer types. Moreover, socioeconomic factors contribute to limited access to fresh and healthy foods and limited opportunities for safe physical activity, leading to poor physical health. In this multidisciplinary, IRB approved study, we explored relationships between demographic factors, self-reported dietary behaviors and gallic acid, a polyphenolic micronutrient that correlates well with fruit and vegetable intake. We recruited participants at a senior center in East Harlem, New York City, a racially diverse and underserved community. The participants completed a NIH-validated survey through which we assessed their dietary habits and collected standardized demographic data and history of cancer. Urine samples from participants were analyzed for gallic acid. So far, 33 participants completed the survey and 25 of them provided urine samples for gallic acid analysis. We found an association between demographic information (Race/ethnicity and age) and intake of certain foods. Specifically, age was negatively associated with french fries/fried potatoes, cooked dried beans and tomato soup intake (p&amp;lt;0.05) and Black/African American race was associated with increased intake of juice (p&amp;lt;0.05). A positive association between self-reported food intake and gallic acid concentration was only observed with french fries/fried potatoes (R = 0.641, p&amp;lt;0.001). Overall, the results suggest a significant association between dietary habits and demographic factors. Ongoing work include further recruitment of participants, and multivariate analysis of the data. This will be followed by an intervention consisting of active nutritional education, and urinary gallic acid analysis to assess the impact of nutritional education on dietary habits. Citation Format: Cristina Zambrano, Maayan Beeber, April Panitz, Katarzyna Wyka, Safa Ibrahim, Yin Tan, Grace Ma, Khursheed Navder, Ming-Chin Yeh, Olorunseun Ogunwobi. Correlation between demographic factors, dietary habits and urinary micronutrient content among minority groups in New York City [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1615.
BRONCHOSCOPIC STUDIES OF PULMONARY ABSCESS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Kaleidoscope
Authors: E. Wesley Ely
Journal: Annals of Internal Medicine (2015)

On Being a Doctor20 January 2015KaleidoscopeE. Wesley Ely, MD, MPHE. Wesley Ely, MD, MPHFrom Vanderbilt University School of Medicine and the Veteran's Affairs Geriatric Research Education and Clinical Center (GRECC) of the Tennessee Valley Healthcare System, Nashville, Tennessee.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-1691 Audio Reading - “Kaleidoscope” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Kaleidoscope," by E.W. Ely. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail As a boy, I was thankful for and humbled by the kaleidoscope.I'll never forget the first time I saw one; I was wandering and bored while shopping with my mom. It was a dusky-brown, dented, cheap-looking metal tube. Deceptively simple and understated. What riches lay there with a mere gaze and rotation into the light? Turn the wheel and witness red shards, turn again and see orange flowering, next yellow explodes into view, then blue seeping into the scene. From then on, I asked all shop owners whether they had kaleidoscopes.So often now, we hear of physician burnout. ... Author, Article, and Disclosure InformationAffiliations: From Vanderbilt University School of Medicine and the Veteran's Affairs Geriatric Research Education and Clinical Center (GRECC) of the Tennessee Valley Healthcare System, Nashville, Tennessee.Corresponding Author: E. Wesley Ely, MD, MPH, Division of Pulmonary and Critical Care Medicine, Health Service Research Center, 6109 Medical Center East, Vanderbilt University School of Medicine, Nashville, TN 37215; e-mail, wes.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Kaleidoscope” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Kaleidoscope," by E.W. Ely. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byBaptism in the ICU 20 January 2015Volume 162, Issue 2Page: 152-153KeywordsAntibioticsComputersCongenital heart defectsHabitsOxygenRacial and ethnic issuesSafetySepsisShouldersTransplantation ePublished: 20 January 2015 Issue Published: 20 January 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
<i>Diseases of the Nervous System. A Text Book of Neurology and Psychiatry</i>. By Smith Ely Jeliffe, M. D., etc., and William A. White, M. D., Superintendent St. Elizabeth Hospital, Washington, D. C., etc. Third Edition, Revised, Rewritten and Enlarged. (<i>Philadelphia and New York: Lea and Febiger, 1919.</i>)
Journal: American Journal of Psychiatry (1920)
Mortality among the Residents of the Three Mile Island Accident Area: 1979-1992
Authors: Evelyn O. Talbott, Ada O. Youk, Kathleen P. McHugh, Jeffrey D. Shire, Aimin Zhang, Brian P. Murphy, Richard A. Engberg
Journal: Environmental Health Perspectives (2000)

The largest U.S. population exposed to low-level radioactivity released by an accident at a nuclear power plant is composed of residents near the Three Mile Island (TMI) Plant on 28 March 1979. This paper (a collaboration of The University of Pittsburgh and the Pennsylvania Department of Health) reports on the mortality experience of the 32,135 members in this cohort for 1979-1992. We analyzed standardized mortality ratios (SMRs) using a local comparison population and performed relative risk regression modeling to assess overall mortality and specific cancer risks by confounding factors and radiation-related exposure variables. Total mortality was significantly elevated for both men and women (SMRs = 109 and 118, respectively). All heart disease accounted for 43.3% of total deaths and demonstrated elevated SMRs for heart disease of 113 and 130 for men and women, respectively; however, when controlling for confounders and natural background radiation, these elevations in heart disease were no longer evident. Overall cancer mortality was similar in this cohort as compared to the local population (male SMR = 100; female SMR = 101). In the relative risk modeling, there was a significant effect for all lymphatic and hematopoietic tissue in males in relation to natural background exposure (p = 0.04). However, no trend was noted. We found a significant linear trend for female breast cancer risk in relation to increasing levels of TMI-related likely [gamma]-exposure (p = 0.02). Although such a relationship has been noted in other investigations, emissions from the TMI incident were significantly lower than in other documented studies. Therefore, it is unlikely that this observed increase is related to radiation exposure on the day of the accident. The mortality surveillance of this cohort does not provide consistent evidence that radioactivity released during the TMI accident has a significant impact on the mortality experience of this cohort to date. However, continued follow-up of these individuals will provide a more comprehensive description of the morbidity and mortality experience of the cohort.