tbuckley/cabot-search huggingface dataset:
Abstract P246: Heart Failure Performance Measures: Eligibility and Implementation In the Community
Authors: Cecilia Berardi, Alanna M Chamberlain, Francesca Bursi, Margaret M Redfield, Sheila M McNallan, Susan A Weston, Ruoxiang Jiang, Veronique L Roger
Journal: Circulation (2012)

Background: The goal of heart failure (HF) performance measures is to improve the quality of care by enabling the practice implementation of guidelines. The guidelines define the population eligible for each measure. Little is known about the proportion of eligible patients to which these measures are applicable in the community. Methods: We determined the eligibility for and the adherence to performance measures and beta-blocker therapy in a community-based cohort of hospitalized patients diagnosed with incident HF from January 2005 to April 2011. Results: Of 294 inpatients with first ever HF (mean age 72 ± 15 years, 48% men), ejection fraction was measured in 292 (99%) patients during hospitalization. Of these, 97 (33%) had an ejection fraction &lt;40% and were thus candidates for beta-blocker and angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blocker (ARB) therapy. After excluding individuals with absolute contraindications, 71 patients were eligible to receive ACE inhibitors or ARB, and 86 were eligible to receive beta-blockers (figure). Among those eligible, 83% received ACEI/ARB and 91% received beta-blockers. Excluding those with relative contraindications, 70 patients were eligible for beta-blockers and 90% of them received it. Among the 139 (47%) individuals with HF and atrial fibrillation, 35 were eligible for warfarin and 49% received it. Of the 36 current smokers, 22 (61%) received cessation counseling during hospitalization. Conclusions: In the community, among patients hospitalized with HF eligible for performance measures, the implementation of performance measures varies by measure and can be improved for some. However, most community HF patients are not eligible for performance measures and other approaches should be identified to improve their care and outcomes.
Variations on a theme
Authors: H. W. Jones
Journal: JAMA (1983)

The theoretical concept of in vitro fertilization has become a clinical reality. This is not to say that there are no unsolved problems with the technique. On the contrary, the variables in the process are many, teamwork of persons with different talents is essential, careful attention to detail is required, and success is often elusive. Despite the vagaries of in vitro fertilization, there has been a remarkable proliferation of programs to carry it out. This speaks on one hand to the demand for help in overcoming infertility and on the other to the willingness of the specialty to embrace new challenges. It would be contrary to experience and therefore naive to expect that all programs will quickly achieve an acceptable viable pregnancy rate. Realism makes it necessary only to hope that the great majority of programs will succeed and to express the additional hope that those who encounter insurmountable obstacles
Cerebral Softening
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious Diseases
Authors: Mark Y. Stoeckle
Journal: JAMA (1992)

The effort to create an effective human immunodeficiency virus (HIV) vaccine has moved to the forefront of acquired immunodeficiency syndrome (AIDS) research. As recently as a few years ago, there was widespread pessimism as to the possibility of an HIV vaccine. The change has been propelled by reports from several laboratories that inactivated or recombinant simian immunodeficiency virus vaccines can induce protective immunity in monkeys. The finding of vaccine-induced immunity to simian immunodeficiency virus, a virus closely related to HIV, suggests that protective immunity against HIV is achievable. Multiple strategies of inducing HIV immunity are being tested, including administration of inactivated virus, recombinant viral proteins, or recombinant live vaccines that express viral antigens. Use of recombinant live vectors, such as Calmette-Guerin bacillus, may be particularly useful in inducing cell-mediated immunity.<sup>1</sup> Pilot studies on the safety and immunogenicity of HIV vaccines are encouraging. For example, phase I trials of a
Coping with gravity
Authors: S. Vaisrub
Journal: JAMA (1978)

To diabetic patients with circulatory autonomic neuropathy, postural hypotension can be a perpetual source of frustration. They may not be able to come to terms with gravity. To their physicians this disability is a source of perplexity. They may find it difficult to explain why therapy is ineffective when etiology and pathophysiology are seemingly well known. How well understood, in effect, is postural hypotension of autonomic diabetic neuropathy? Normally, a rise to the upright position causes blood to pool in the lower extremities with resulting fall in venous pressure, cardiac output, and arterial blood pressure. These changes provoke instantaneous reflex peripheral vasoconstriction, increased heart rate, and a rise in plasma norepinephrine and renin levels. As a result of these compensatory adjustments, the vascular hemodynamic steady state is restored, and the blood pressure promptly returns to its previous level. Compromised baroreceptor reflexes and damaged sympathetic innervation of the peripheral vasculature have
Medical Greats
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exercise and the Heart
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A SIMPLE METHOD OF STAINING GRAM-NEGATIVE ORGANISMS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of social class on obesity and thinness in children
Authors: A. Stunkard
Journal: JAMA (1972)

Several social factors have been closely linked to obesity and thinness in adults. This study, based on 3,344 measurements of triceps skin-fold thickness found similar relationships in white urban children. Obesity was far more prevalent in the lower-class girls than in those of the upper class—nine times as prevalent by age 6. Similar though less striking differences were found between boys of upper and lower socioeconomic status. The pattern of thinness among girls was similar to that previously reported in women, with significantly more thinness in the upper-class group. Among boys, as among men, there were no such differences. The remarkably early onset of class-linked differences in prevalence of obesity underlines the importance of attempts to prevent the disorder in childhood. These attempts should be directed particularly toward those at high risk because of their lower socioeconomic status.
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1889)

Dr. Roger S. Tracy's Report to the Board of Health on the Mortality of the City—The Board disseminating among the People a knowledge of the Contagiousness of Tuberculosis. A preliminary report in relation to the mortality in this city for the year 1888, recently presented to the Board of Health by Dr. Roger S. Tracy, Assistant Sanitary Superintendent, has attracted considerable attention on account of the somewhat surprising deductions which he makes from the results of his investigations. These are as follows: "The death-rate in tenement houses is less than the general death-rate of the city. The death-rate in the large tenement houses is less than in the smaller ones. That while diarrhœal diseases and diphtheria show a greater death-rate in the larger houses (leaving out the suburban districts, where the conditions are very different), phthisis and pneumonia show comparatively little difference; that difference, however, being in favor of the
Biomarker studies in northern Bohemia
Authors: B Binková, J Lewtas, I Mísková, P Rössner, M Cerná, G Mrácková, K Peterková, J Mumford, S Meyer, R Srám
Journal: Environmental Health Perspectives (1996)

Studies were conducted in northern Bohemia to simultaneously evaluate personal exposures to air pollution in the form of respirable particles containing polycyclic aromatic hydrocarbons (PAHs) and biomarkers of exposure, biological effective dose, genetic effects, and metabolic susceptibil- ity.The series of biomarkers included PAH metabolites in urine, urine mutagenicity, PAH-DNA adducts in white blood cells determined by32P-postlabeling, PAH-albumin adducts determined by enzyme-linked immunosorbent assay (ELISA), DNA damage in lymphocytes detected by comet assay, chromosomal aberrations, sister chromatid exchanges, and glutathione S-transferase Ml (GSTM1) genotypes.For these studies, a group of women who work outdoors about 30% of their daily time was selected.In a pilot study, a group of women from a polluted area of the Teplice district (northern Bohemia) was compared with a group of women from a control district of southern Bohemia (Prachatice).In a follow-up repeated-measures study, a group of nonsmoking women from Teplice was sampled repeatedly during the winter season of 1993 to 1994.Personal exposure monitoring for respirable particles (<2.5 pm) was conducted for the 24-hr period before collection of blood and urine.Particle extracts were analyzed for carcinogenic PAHs.In the pilot study and in the follow-up study, a highly significant correlation between individual personal exposures to PAHs and DNA adducts was found (r= 0.54, p= 0.016; r= 0.710, p< 0.001, respectively).The comet parameter (percentage DNA in tail; %T) correlated with exposures to respirable particles (r=0.304,p=0.015).The GSTM1 genotype had a significant effect on urinary PAH metabolites, urine mutagenicity, and comet parameters (%T and tail moment) when the GSTM1 genotype was considered as a single factor affecting these biomarkers.Multifactor analysis of variance considering exposure and adjusting the data for GSTM1, age, and diet showed that the effect of personal exposures to PAHs on the variability of biomarkers (DNA adducts, comet parameters, urine mutagenicity) might be higher than the effect of the GSTM1 genotype.These results show the importance of considering all potential factors that may affect the biomarkers being analyzed.
Correction: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells
Authors: Alejo Chorny, Sandra Casas-Recasens, Jordi Sintes, Meimei Shan, Nadia Polentarutti, Ramón García-Escudero, A. Cooper Walland, John R. Yeiser, Linda Cassis, Jorge Carrillo, Irene Puga, Cristina Cunha, Hélder Bastos, Fernando Rodrigues, João F. Lacerda, António Morais, Rebeca Dieguez-Gonzalez, Peter S. Heeger, Giovanni Salvatori, Agostinho Carvalho, Adolfo Garcia-Sastre, J. Magarian Blander, Alberto Mantovani, Cecilia Garlanda, Andrea Cerutti
Journal: The Journal of Experimental Medicine (2017)
Palliative
Authors: Rebekka E. DePew
Journal: Annals of Internal Medicine (2018)

Ad Libitum2 October 2018PalliativeRebekka E. DePewRebekka E. DePewVanderbilt University Medical School, Nashville, Tennessee (R.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-1351 Audio Reading - “Palliative” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Palliative," by R.E. DePew. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When we were young we called them wishing flowers,because what else would you do with a living thingthat wants so strongly to spread itself, to be more,that it is willing to loosen its hold on existence enoughto be blown away by a child's breath. The stalk is leftbehind, discarded and milky green. At times like these,scared of death, too. We learn ... Author, Article, and Disclosure InformationAffiliations: Vanderbilt University Medical School, Nashville, Tennessee (R.D.)Current Author Address: Rebekka E. DePew; e-mail, rebekka.e.[email protected]erbilt.edu. PreviousarticleNextarticle Advertisement Audio Reading - “Palliative” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Palliative," by R.E. DePew. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 2 October 2018Volume 169, Issue 7Page: 489 ePublished: 2 October 2018 Issue Published: 2 October 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AORTIC STENOSIS
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The impact of exogenous estrogen exposure on the characteristics of estrogen receptor (ER) positive, early-stage breast cancer (EBC).
Authors: Orly Yariv, Rinat Yerushalmi, Assaf Moore, Tzippy Shohat, Ofer Rotem, Korzets Ceder Yasmin, Hadar Goldvaser
Journal: Journal of Clinical Oncology (2020)

e12606 Background: Oral contraceptives (OC) and hormone replacement therapy (HRT) are well-established risk factors for ER positive breast cancer. Infertility is associated with an increased breast cancer risk and there is conflicting data on the influence of fertility treatments on breast cancer risk. The impact of exogenous estrogen exposure on breast cancer characteristics is not well described. Methods: A single center retrospective cohort study comprising all women with ER positive, human epidermal growth factor receptor 2 (HER2) negative, EBC whose tumors were sent to OncotypeDX analysis treated in our institute between 2005 and 2012. Data on exogenous estrogen exposure were collected including: OC and HRT use and prior fertility treatments. The impact of these exposures was assessed on pre-specified histopathological features including: tumor size, nodal status, ER and progesterone receptor (PR) staining, grade, Oncotype recurrence score (RS), ki67, lymphovascular and perineural invasion. Results: A total of 620 women were included, 79% were postmenopausal. Prior exposure to OC, HRT and fertility treatments was documented in 19% (103), 30% (136) and 11% (62), respectively. OC use was associated with smaller (≤1cm) tumors (30% vs. 20%, p = 0.023) and were less likely to have grade 3 disease (10% vs. 19%, p = 0.049). No other associations were found between exogenous estrogen exposures and tumor characteristics (Table). Conclusions: Use of OC may be associated with breast cancer with a distinct features compared to women with luminal breast cancer without history of OC use. Large scale studies are needed to better characterize these findings. [Table: see text]
MEDITERRANEAN FEVER.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Caravaggio
Authors: James A. Brussel
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The Caravaggio cover and story (April 3) were superb. A few amazing data about this alcoholic-sociopath might interest readers. In the world of art, Caravaggio was the first painter to dress Biblical characters in contemporary attire ("The Feast at Emmaus," in the National Art Gallery). He was a lush who was constantly in trouble and confined overnight in jail to "dry out." Many mornings, when he awoke, he was fascinated by the bright rays of sunlight that came through the tiny barred window near the ceiling. He would pass his hand in and out of the alternating black and white stripes. From this came his original work in<i>chiaroscuro</i>which, with time, he effectively combined with startlingly contrasting vivid reds, as in "St. Jerome Writing." He was as crooked as a corkscrew. He is said to "hold the world's record" for accepting commissions and advances, spending the