tbuckley/cabot-search huggingface dataset:
A QSAR Evaluation of Ah Receptor Binding of Halogenated Aromatic Xenobiotics
Authors: Ovanes G. Mekenyan, Gilman D. Veith, Daniel J. Call, Gerald T. Ankley
Journal: Environmental Health Perspectives (1996)

Because of their widespread occurrence and substantial biological activity, halogenated aromatic hydrocarbons such as polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and polychlorinated dibenzo-p-dioxins (PCDDs) comprise one of the more important classes of contaminants in the environment. Some chemicals in this class cause adverse biological effects after binding to an intracellular cytosolic protein called the aryl hydrocarbon receptor (AhR). Toxic responses such as thymic atrophy, weight loss, immunotoxicity, and acute lethality, as well as induction of cytochrome P4501A1, have been correlated with the relative affinity of PCBs, PCDFs, and PCDDs for the AhR. Therefore, an important step in predicting the effects of these chemicals is the estimation of their binding to the receptor. To date, however, the use of quantitative structure activity relationship (QSAR) models to estimate binding affinity across multiple chemical classes has shown only modest success possibly due, in part, to a focus on minimum energy chemical structures as the active molecules. In this study, we evaluated the use of structural conformations other than those of minimum energy for the purpose of developing a model for AhR binding affinity that encompasses more of the halogenated aromatic chemicals known to interact with the receptor. Resultant QSAR models were robust, showing good utility across multiple classes of halogenated aromatic compounds.
Sweat Tests
Authors: Harry Shwachman
Journal: JAMA (1978)

<h3>To the Editor.—</h3> It is appalling to note the high frequency of unreliable sweat tests. Some of the reasons for this poor performance are as follows: (1) the lack of interest of clinical chemists, (2) poorly trained technicians, (3) use of poorly standardized equipment, (4) the infrequency with which the test is done, (5) failure of the laboratory to establish internal standards, and (6) the complacency of pediatricians in accepting inadequate and sloppy reports. Many clinical chemists will shy away from having a patient come to the laboratory for the first two steps in the sweat test, ie, stimulating local sweat glands by pilocarpine (step 1), but will gladly accept a specimen of sweat for analysis. Step 2 is the collection of the sweat into either a gauze pad or filter pad. These specimens may or may not be acceptable for analysis because of small volume, inadequate collection, contamination, or
Accumulation of Di-2-Ethylhexyl Phthalate (DEHP) in Whole Blood, Platelet Concentrates, and Platelet-Poor Plasma. 1. Effect of DEHP on Platelet Survival and Function
Authors: C. R. Valeri, T. J. Contreras, H. Feingold, R. H. Sheibley, R. J. Jaeger
Journal: Environmental Health Perspectives (1973)
REINVENT (REgorafenIb traNslational eValuation angiogENesis proTocol)
Authors: A. Dessì, L. Demurtas, S. Tolu, M. Puzzoni, A. Cubeddu, E. Lai, G. Pusole, R. Mascia, P. Ziranu, L. Orgiano, V. Pusceddu, G. Astara, C. Madeddu, E. Massa, L. Casula, M. Scartozzi
Journal: Annals of Oncology (2016)
Abstract P256: Myocardial Infarction is not a Risk Factor for Hospital-Acquired Venous Thrombosis: The Medical Inpatients Thrombosis (MITH) Study
Authors: Neil A Zakai, Peter W Callas, Allen B Repp, Mary Cushman
Journal: Circulation (2012)

Introduction: Venous thrombosis (VT) complicating medical admission is common and the risk factors are poorly understood. Myocardial infarction (MI) is often considered a risk factor for hospital-acquired VT with very little data other than expert opinion to support this assertion. We hypothesized that due to use of antithrombotic medications and early mobilization that MI may not be a hospital-acquired VT risk factor. Methods: All cases of VT complicating medical admission were found between 01-2002 and 06-2009 at a 500 bed teaching hospital using ICD-9 discharge codes and confirmed by medical record review. Controls were frequency matched 2:1 to cases by admission year and medical service and weighted by the inverse sampling probability. Acute MI was defined as acute MI on the discharge summary, and prior MI as mention of prior MI on the admission note. We used multivariable weighted logistic regression and the Taylor series to calculate odds ratios and 95% confidence intervals (CI) for VT for acute MI and prior MI. Models included age and sex, and a VT risk score previously developed. Results: Two-hundred ninety-nine cases of VT complicated 64,334 admissions (4.6 per 1000 admissions), 16 VT occurred in the 7,240 patients admitted with acute MI (2.2 per 1000 admissions). The table presents the percent of cases and hospital admissions with prior MI and acute MI, and the age- and sex-adjusted OR and multivariable-adjusted OR for VT. Prior MI was associated with a reduced odds of VT in both models ( Table ) while acute MI was not associated with VT accounting for VT risk factors (OR 0.83 95% CI 0.34, 2.01). Discussion: In contrast to ‘conventional wisdom’, prior MI and acute MI were not risk factors for hospital-acquired VT. For acute MI, short hospital stays, use of antithrombotic medications, and early mobilization after the MI may affect hospital-acquired VT risk. For prior MI, statin use and lifestyle changes may reduce hospital-acquired VT risk, however further work is needed to confirm this finding. Table Association of Acute MI and History of MI with Hospital-Acquired VT Cases (%) (n = 299) Hospital Admissions (%) (n = 64,334) Odds Ratio for VT Age-,Sex- Adjusted Multivariable Adjusted * Past History of MI 5.8% 25.9% 0.44 (0.27, 0.73) 0.35 (0.18, 0.67) MI on Admission 5.3% 11.3% 0.49 (0.23, 1.02) 0.83 (0.34, 2.01) * Adjusted for VTE prophylaxis use (mechanical and pharmacologic), full anticoagulation use, heart rate &gt;100 on admission, hypoxic or ventilated on admission, history of VT, fracture in past 3 months, cancer in past 12 months, past history of congestive heart failure, and past history of a rheumatologic or inflammatory disease.
Utilization and cancer detection by U.S. prostate biopsies (2005-2011).
Authors: Carl A. Olsson, Deepak A. Kapoor, Savvas E. Mendrinos, Ann E. Anderson, David G. Bostwick
Journal: Journal of Clinical Oncology (2013)

107 Background: To assess the positive biopsy rate and core sampling pattern in patients undergoing prostate biopsy in the US at a national reference laboratory and pathology laboratories integrated into urology group practices and analyze the relationship between positive biopsy rates and number of specimen vials per biopsy (sv/b). Methods: For the years 2005-11, we collected pathology data from a national reference laboratory (NRL) including number of urologists and urology practices referring samples, total specimen vials submitted per prostate biopsy, and final diagnosis for each case. The diagnoses were categorized as benign, malignant, prostatic intraepithelial neoplasia or atypical small acinar proliferation. Over the same period, similar data was gathered from urology practices with in-house laboratories performing global pathology services (urology practice labs, UPL) identified by a member survey of the Large Urology Group Practice Association. For each year studied, positive biopsy rate and number of specimen vials/biopsy were calculated in aggregate and separately for each site of service. Results: From 2005-11, 437,937 biopsies were submitted in 4,230,129 vials (9.4 sv/b); overall positive biopsy rate was 40.3%, identical at both the NRL and UPL (p=0.97). Nationally, the number of specimen vials/biopsy increased sharply from a mean of 8.8 during 2005-8 to 10.3 from 2009-11 (difference 1.5 sv/b, p=0.03). For the most recent 3 year period (2009-11), there was no significant difference between the NRL (10.0 sv/b) and UPL (10.6 sv/b) (p=0.08). Positive biopsy rate correlated strongly (p&lt;0.01) with number of specimen vials/biopsy. Conclusions: The positive prostate biopsy rate of 40.3% is identical across sites of service. Although there was a national trend towards increased specimen vials/biopsy from 2005-11, from 2009-11 there was no significant difference in specimen vials/biopsy across sites of service. Increased cancer detection rate correlated significantly with increased number of specimens examined. Segregation of prostate biopsy cores into 10-12 unique specimen vials has been adopted by urologists across sites of service and can be considered the de facto national standard of care.
American Journal of Surgery, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fahrenheit 250
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic damage from diagnostic radiation
Authors: I. D. Bross
Journal: JAMA (1977)

Using the data from the Tri-State Leukemia Survey and a mathematical model, the hypothesis that low levels of diagnostic radiation produce severe genetic damage that is expressed in the child of the exposed person as leukemia and other diseases is tested. It is estimated that for about 1% of the exposed persons who are affected by radiation, there is a 50-fold increase in the risk of leukemia and a five-fold increase in certain other diseases. (<i>JAMA</i>237:2399-2401, 1977)
ESGE Newsletter
Journal: Endoscopy (2010)

The ESGE sponsored Endoscopy Workshop took place in Yaroslavl (Russia) on July the 1st and 2nd, 2010. This was the first time that an official ESGE activity was organized in Russia, and it could not have been more successful. The event had been very well prepared in all the details by the local organizing committee chaired by Dr Serghey Kashin with the support of the local administrative powers, both political and academic. On the other hand, ESGE and ESGENA together with the official technical sponsors Olympus and Cook Endoscopy gave, once again, the proof of a perfect symbiotic organizing effort leading to a great success. More than 350 doctors coming from all over Russia, but also from several surrounding countries attended the meeting, together with more than 60 nurses. The program, as usual, comprehended both state of the art lectures and live demonstrations broadcasted to the beautiful Auditorium of the House of the Government of the Yaroslavl Region from the state-of-the-art equipped Endoscopy Unit of the Oncological Centre of Yaroslavl, directed by Dr. Kashin. Six ESGE experts, Guido Costamagna (Italy) (who was also Co-Director of the Workshop together with Boris Poddubny, President of the Russian Society of Digestive Endoscopy), Hans-Dieter Allescher (Germany), Thierry Ponchon (France), Olivier Le Moine (Belgium), Stefan Seewald (Switzerland) and Hiroshi Kashida (Japan) with the excellent assistance of 4 ESGENA experts (Michael Ortmann – Switzerland, Sylvia Lahey – The Netherlands, Jadranka Brljak – Croatia, and Herta Pomper – Austria) and the indispensable help of Russian doctors and nurses were able to treat more than twenty five patients during the live sessions. Several endoscopic diagnostic and therapeutic techniques were demonstrated: EMR and ESD and ploypectomy in the upper and lower GI tract, single-balloon enteroscopy, EUS-guided FNA and pancreatic cyst drainage, esophageal stent placement, biliary stones removal, stenting of the bile duct, etc. The technical support of Olympus and Cook Endoscopy has been, as usual, of paramount importance for the smooth progress of the program. Parallel to the main session, there were special sessions dedicated to nurses, both theoretical and practical (hands-on). In particular, the hands-on training which was very much appreciated by the attendees, has been realized thanks to the enormous effort put in this activity by the team of Olympus Europe.
Chemical Pathology. A Discussion of General Pathology from the Standpoint of the Chemical Processes Involved.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LONDON
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Medicine
Authors: David R. Dantzker
Journal: JAMA (1992)

In the last few years, there have been significant changes in our understanding of the pathophysiology and approach to treatment of a number of pulmonary disorders. In 1981, heart-lung transplantation was introduced as the first truly viable option for the long-term treatment of pulmonary hypertension secondary to primary pulmonary hypertension and Eisenmenger's syndrome. In the short time since then, breakthroughs in surgical techniques and the availability of cyclosporine have permitted a number of new transplantation techniques, including single-lung, double-lung, and now bilateral sequential lung transplants. Single-lung replacement initially was recommended only for patients with end-stage interstitial lung disease. The transplant procedure improved overall function, and the use of only one lung simplified the surgical technique compared with heart-lung transplantation, lowering the perioperative morbidity and mortality and increasing the number of organs available for transplantation. Initially, it was thought that a single-lung transplant would be inappropriate for patients with associated cor
The Vitreous Humor: Postmortem Potassium Changes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
System of Surgery
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isoniazid Hepatitis
Authors: THEODORE L. BADGER
Journal: Annals of Internal Medicine (1974)

Comments1 January 1974Isoniazid HepatitisTHEODORE L. BADGER, M.D.THEODORE L. BADGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-1-113 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt. . . Maddrey and Boitnott's paper, "Isoniazid Hepatitis," in the July issue . . . does not prove or, at least, not make clear, that in Baltimore, where there is a high incidence of hepatitis, other factors did not play a part in the high mortality in their cases. This latter should be made very clear by further investigation of their associated health problems, if any.Isoniazid is an extraordinarily valuable adjunct for our national program on the prevention and eradication of tuberculosis. Although its dangers should be documented, false association should not be assumed.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIsoniazidIVAL L. SALYER, M.D., MICHAEL H. CYNAMON, M.D.Stop Isoniazid ProphylaxisHAROLD L. ISRAEL, M.D., F.A.C.P. 1 January 1974Volume 80, Issue 1Page: 113-114KeywordsHepatitisHepatitis AIsoniazidMortality Issue Published: 1 January 1974 PDF DownloadLoading ...
The Impact of Routine HTLV-III Antibody Testing of Blood and Plasma Donors on Public Health
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal