tbuckley/cabot-search huggingface dataset:
Plasma-Cell Myeloma
Authors: Elliott F. Osserman
Journal: New England Journal of Medicine (1959)

Pathologic Proteinuria and Renal InsufficiencyImpairment of renal function, characterized by nitrogen retention in the absence of hypertension, occurs in over 50 per cent of cases of plasma-cell myeloma.1–9 In many cases, the renal damage can be directly related to the excretion of abnormal, low-molecular-weight Bence-Jones proteins and the damaging effects of these proteins on the renal tubules and ultimately on the entire nephron,131 132 133 whereas in others, a combination of pathogenic mechanisms may be responsible.131 132 133 134 135 136 137 138 139 Thus, hypercalcemia and excessive calcium loading of the kidneys may produce transient or, at times, irreversible tubular damage; anemia, per se, may compromise renal function, . . .
Longer consolidation duration is required to reduce 1-year clinical relapse rate after stopping tenofovir in HBeAg negative CHB patients
Authors: Rachel Wen-Juei Jeng, Chien-Hung Chen, Yi-Cheng Chen, I-Shyan Sheen, Rong-Nan Chien, Yun-Fan Liaw
Journal: Journal of Hepatology (2020)
Intra-arterial alprostadil for nonatherosclerotic vasculopathy
Authors: D. L. Wooster
Journal: JAMA (1981)

A 33-year-old man with a nonatherosclerotic vasculopathy of undetermined origin had progressive occlusive disease of the lower limb vessels. The resultant severe rest pain and ischemic ulceration of his foot were inoperable and unresponsive to conventional drug therapy. Treatment was begun with intra-arterially administered alprostadil (prostaglandin E<sub>1</sub>), a vasodilator and inhibitor of platelet aggregation. Although immediate benefit was equivocal, his rest pain had disappeared six weeks after infusion, and the ischemic ulcer almost healed completely. Blood flow studies showed increased flow to the feet, consistent with the subjective improvement. The beneficial effect of alprostadil suggests that further studies with this agent are warranted for patients with nonatherosclerotic vasculopathy. (<i>JAMA</i>1981;245:1846-1849)
Structural Decay of Bone Microarchitecture in Men with Prostate Cancer Treated with Androgen Deprivation Therapy
Authors: E. J. Hamilton, A. Ghasem-Zadeh, E. Gianatti, D. Lim-Joon, D. Bolton, R. Zebaze, E. Seeman, J. D. Zajac, M. Grossmann
Journal: Endocrine Reviews (2010)

ContextAndrogen deprivation therapy (ADT) used in the treatment of prostate cancer reduces bone mineral density (BMD) and predisposes to fractures. The structural basis of the BMD deficit and bone fragility is uncertain.
The Surgery of the Head.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Automatic Defibrillation
Authors: M. Mirowski
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In "Defibrillatory Treatment of Exertional Cardiac Arrest in Coronary Disease" (<b>216</b>: 653, 1971), Bruce and Kluge wrote...it is of interest to note that a laboratory model of an automatic standby defibrillator has been developed and successfully tested on dogs. With further bioengineering improvements, one might hope that a satisfactory clinical approach analogous to a transvenous pacemaker for treatment of heart block will become available for selected patients at the greatest risk for ventricular fibrillation. Such a device might well protect the isolated patient remote from emergency facilities. If a reader were sufficiently intrigued by this statement to want to look further into the matter, he would be disappointed to find that Bruce and Kluge have failed to include a reference to the original report, commented upon in an EDITORIAL<sup>1</sup>(213: 615, 1970). We may be biased in our attitude, but think that such an extensive discussion of
JCSE01.16 Metastatic Lymph Nodes as High Immunogenicity Media for Perioperative Immunotherapy in Locally Advanced NSCLC
Authors: C. Zhang, S. Liu, J. Su, X. Gao, L. Chang, Y. Guan, H. Tu, J. Yang, X. Zhang, W. Zhong
Journal: Journal of Thoracic Oncology (2019)
Gastric aspiration in localization of gastrointestinal hemorrhage
Authors: G. D. Luk
Journal: JAMA (1979)

We compared the findings from gastric aspiration for blood with the site of gastrointestinal (GI) hemorrhage ultimately identified by endoscopy or angiography in 1,190 patients whose cases were analyzed retrospectively and prospectively during a six-year period. Gastric aspirates were positive for blood in 837 patients. An upper GI site proximal to Treitz' ligament was identified in 93%, and none had a lower GI site. A negative aspirate was found in 353 patients; a lower GI site was identified in 60%, and 1% (three patients) had an upper GI site. In these three patients, hemorrhage occurred in clinical settings suggesting ulcer disease, and bleeding duodenal ulcers were found in all three. All of the other 180 patients with a bleeding duodenal ulcer had a positive gastric aspirate. (<i>JAMA</i>241:576-578, 1979)
Letter: Mobile resuscitation units.
Authors: Robert Harrison, S Campbell
Journal: BMJ (1976)

menses in each patient, one before treatment, two while on ethamsylate (500 mg four times daily from five days before the anticipated onset of menstruation for 10 days) and two while on indistinguishable doses of placebo with double-blind random allocation of each of the tablets.The Wilcoxon signed rank test was used in statistical analysis of the results.Mean blood loss was 64-8 ml before treatment and 64-6 ml during placebo therapy (P>010) but was significantly less (53-5 ml; P <0-05) during administration of ethamsylate.The mean percentage reduction in blood loss was 18-6+4-7, giving a range at the 95% con- fidence level of 8-4-28-8.Such results, if confirmed by a longer series, would suggest that a patient with an IUD in situ who complained of menorrhagia should be offered ethamsylate as primary treatment.This could prove sufficiently effective in controlling the cycle to make further manipulation unnecessary.
Microsurgery Can Be Telecast
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 174: Relationship between Kawasaki Disease Related-Angiopathy and Pressure Wave Reflection in the Arterial System
Authors: Yo Shimizu, Tsuneyuki Nakamura, Giyo Ko, Chisato Akita, Yutaka Saikawa
Journal: Circulation (2015)

Background: Recently we reported that the carotid arteries of Kawasaki disease (KD) appear to develop mild sclerotic changes shortly after onset using the speckle tracking echocardiography. However, it remains to be elucidated what factors hemodynamically may induce these sclerotic changes. Objectives: The aim of this study was to investigate the relationship between KD related-angiopathy and arterial pressure wave reflection using the two-dimensional speckle tracking echocardiography and radial augmentation index (AIx). Subjects &amp; Methods: We studied a cohort of children with history of KD. The subjects were 87 KD patients (age, 9.7±2.9 years) and 93 healthy controls (11.3±3.2 years). As for our methodology, the two regions of interest (ROI) for speckle tracking were manually positioned at near and far carotid arterial walls using a Philips iE33. Continuously, we examined the following strain values: (A) peak strain in expansion phase, (B) peak strain before aortic valve closure, and (C) strain value at aortic valve closure (Figure 1). Also, we examined two ratios, B/A and C/A, for emphasizing recoil function. Concurrently, the radial AIx were obtained. Results: KD patients had significantly the lower A values, the higher B/A, and the higher radial AIx, compared with controls. Furthermore, there was good correlation between B/A and radial AIx in KD. Conclusions: It is well known that a higher AIx results from earlier arrival of reflected pressure waves and an early return of reflected waves is closely correlated with peripheral stiffness. Therefore, these results indicate that peripheral angiopathy may induce sclerotic changes of carotid arteries in KD patients.
REPORT OF LIBRARIAN.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intravenous Immunoglobulin Reduces Anti-HLA Alloreactivity and Shortens Waiting Time to Cardiac Transplantation in Highly Sensitized Left Ventricular Assist Device Recipients
Authors: Ranjit John, Katherine Lietz, Elizabeth Burke, Jan Ankersmit, Donna Mancini, Nicole Suciu-Foca, Niloo Edwards, Eric Rose, Mehmet Oz, Silviu Itescu
Journal: Circulation (1999)

Background —Recipients of left ventricular assist devices (LVADs) develop prominent B-cell hyperreactivity. We investigated the influence of anti-HLA antibodies on waiting time to cardiac transplantation in LVAD recipients and compared the effects of 2 immunomodulatory regimens on anti-HLA serum reactivity. Methods and Results —Fifty-five previously nonsensitized LVAD recipients of a TCI device implanted between 1990 and 1996 were studied. Patients with anti-HLA antibodies received monthly courses of either intravenous immunoglobulin (IVIg) or plasmapheresis, in conjunction with cyclophosphamide. The effects of these regimens on anti-HLA alloreactivity and waiting time to transplantation were then determined by Kaplan-Meier log-rank statistics, nonparametric Wilcoxon rank-sum test, and Student’s t test. Prolongation in transplant waiting time was related to serum IgG anti–HLA class I alloreactivity. Infusion of IVIg (2 g/kg) caused a mean reduction of 33% in anti–HLA class I alloreactivity within 1 week. Waiting time to transplantation was significantly reduced by IVIg therapy and subsequently approximated that in nonsensitized patients. Side effects of IVIg (2 g/kg) were minimal and related primarily to immune complex disease. Although plasmapheresis caused a similar reduction in alloreactivity to IVIg, this effect was achieved after longer treatment. Moreover, plasmapheresis was associated with an unacceptably high frequency of infectious complications. In patients resistant to low-dose (2 g/kg) IVIg therapy, high-dose (3 g/kg) IVIg was effective in reducing alloreactivity but was associated with a high incidence of reversible renal insufficiency. Conclusions —These results indicate that IVIg is an effective and safe modality for sensitized recipients awaiting cardiac transplantation, reducing serum anti-HLA alloreactivity and shortening the duration to transplantation. The therapeutic and safety profile of IVIg would appear to be superior to plasmapheresis.
Transmission Risk Poses Emergency
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatric testimony: what are its limits?
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methoxyflurane nephrotoxicity
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORRESPONDENCE
Authors: Keith M. Bagnall, Edward M. Winter
Journal: British Journal of Sports Medicine (1975)

At one time, deviant behaviour in boxers was attributed to their aggressive personalities rather than to repetitive minor brain damage, but this view is changing, following work by such as H. S. Martland and N. Corsellis.I have reliable information of a Sri Lankan boxer who tried to murder his wife and is now certified insane.Floyd Patterson was admitted to hospital concussed after his defeat by Sonny Liston; Benny Kid Paraet died in coma after a knock-out by Emil Griffiths; Carmino Vingo had to retire with permanent brain damage after defeat by Rocky Marciano.Partly as a result of these severe injuries in PROFESSIONAL boxing, the very different AMATEUR sport is becoming much less popular all over the world, and is far less popular in Sri Lankan schools.Boxing, however, is still a most popular sport from the spectators' viewpoint, and is a sport that attracts a great deal of money throughout most of the world.It is one of the few ways open to boys from a poor background, especially in the U.S.A., Cuba and parts of Africa with a large population of African descent, to find a way of making a successful career.It would therefore be tragic if this type of activity were to cease.
OCCURRENCE OF THE STRONGYLOIDES INTESTINALIS IN THE UNITED STATES.
Authors: MARSHALL LANGTON PRICE
Journal: JAMA (1903)

I present for your consideration a somewhat brief and imperfect account of one of the rarer nematodes; rare, at least in this climate and latitude, though occurring with considerable frequency in tropical and sub-tropical countries. I refer to the<i>Strongyloides intestinalis</i>. The parasite is endemic in Cochin China, where it occurs in association with the diarrhea peculiar to the country—hence the name bestowed on it by European physicians, "Cochin China diarrhea." This animal forms one of the class of parasites whose pathologic action is limited to the intestinal canal, and does not extend, as does that of the<i>Amœba coli</i>, to the liver and other organs. Teissier has claimed to have observed rhabditiform embryos circulating in the blood, and to have produced metastatic foci in the lungs of infected frogs. These observations, however, have not been confirmed by any other observer, and, for the present, we must conclude that the parasite's pathologic influence is lmited
Hepatitis B virus integration in hepatitis B virus-related hepatocellular carcinoma in childhood
Authors: M Chang
Journal: Hepatology (1991)

In Taiwan, hepatocellular carcinoma is one of the major malignancies in children between 5 and 14 yr of age. We studied the status of hepatitis B virus DNA in the hepatocellular carcinoma and nontumorous liver tissues of eight children with positive serum HBsAg and maternal HBsAg. The hepatocellular carcinoma tissues from five of the eight children showed integration of hepatitis B virus DNA into host cellular DNA sequences. A pattern of single-site integration in four children and a multiple-site integration pattern in one child were demonstrated. In the remaining three children, hepatitis B virus DNA could not be demonstrated in the tumor tissues. Using subgenomic fragments of the hepatitis B virus genome as probes, we found that the X gene fragment and the surface antigen gene fragment were the most conserved sequences. The single-site integration of hepatitis B virus DNA in childhood hepatocellular carcinoma may have hit the critical region, resulting in insertional mutagenesis and early development of hepatocellular carcinoma. With a short incubation period and less exposure to environmental carcinogens during early life, childhood hepatocellular carcinoma may provide a good model to study the carcinogenic potential of hepatitis B virus. (HEPATOLOGY 1991;13:316–320).
Making optimum use of the microbiology laboratory. III. Aids of antimicrobial therapy
Authors: R. C. Bartlett
Journal: JAMA (1982)

PREVIOUS articles in this series have emphasized the need for physicians to review with microbiologists ways of obtaining results from the microbiology laboratory that are more useful. Physicians and microbiologists must work together to facilitate interpretation of laboratory data used to guide antimicrobial therapy. The techniques used and the mode of reporting information should optimize therapy at minimum cost. <h3>ANTIMICROBIAL SUSCEPTIBILITY: 'S-I-R' VS MICs</h3> In recent years, much technological change has occurred in the in vitro testing of antimicrobial susceptibility of bacteria isolated from clinical specimens. The disk method of testing was applied initially in a highly unstandardized manner and led to unreliable results in many instances. More recently, the Kirby-Bauer method has become highly standardized in the majority of laboratories. Still, most physicians are only vaguely aware of how the designations "S," "I," and "R," which stand for<i>sensitive, intermediate (or indeterminate) sensitivity</i>, and<i>resistance</i>, relate to achievable antimicrobial
Measles Pneumonia
Authors: Robert W. Olson
Journal: JAMA (1975)

During a 3 1/2-month period, 32 previously healthy young men were first seen with typical prodromal symptoms and signs of measles. On admission or within 48 hours of admission, 16 patients (50%) manifested physical signs and roentgenographic evidence of pneumonia. Of these 16 patients, ten (63%) were found to have bacterial suprainfection or colonization confirmed by culture of transtracheal aspirates. From six of these ten patients,<i>Neisseria meningitidis</i>serogroup Y was isolated as the sole organism responsible for suprainfection. In the other four patients,<i>Haemophilus</i>species,<i>Neisseria</i>species (not<i>N gonorrheae</i>or<i>N meningitidis</i>),<i>Streptococcus pneumoniae</i>, and β-hemolytic<i>Streptococcus</i>(not group A or D) were isolated alone or in combination. The data suggest that bacterial suprainfection associated with measles pneumonia is not unusual in adults and<i>N meningitidis</i>serogroup Y is a potential pathogen of the lower respiratory tract. (<i>JAMA</i>232:363-365, 1975)