tbuckley/cabot-search huggingface dataset:
Effects of the V1a vasopressin agonist F-180 on portal hypertension-related bleeding in portal hypertensive rats
Authors: J Morales
Journal: Hepatology (2003)

F-180 is a new, long-acting analog of vasopressin with a selective agonist effect on the vascular V1a receptors, with the advantage of having no effect on renal V2 receptors. F-180 is approximately 20 times more powerful than terlipressin in reducing portal pressure and has less marked systemic effects. The present study investigated the effects of F-180 on the outcome of portal hypertension-related bleeding in hypovolemic rats. Partial portal vein-ligated rats were subjected to portal hypertension-related bleeding by sectioning a first-order branch of the ileocolic vein. After hemodynamic stabilization, a second sectioning of the first-order branch of the ileocolic vein section was performed in the already hypovolemic animals, and either F-180 or placebo was administered. Blood transfusion was adjusted to maintain mean arterial pressure (MAP) γ > 80 mm Hg. The first section of a first-order branch of the ileocolic vein induced a hemorrhage of similar severity in both groups of rats. After a 2nd sectioning of a first-order branch of the ileocolic vein section, F-180 was more effective than placebo in recovering shock (MAP, 21% ± 23% vs. 0% ± 13% in placebo; P < .05), preventing portal pressure (PP) increase during blood transfusion (PP: −1% ± 19% vs. 47% ± 65% in placebo; P = .07), reducing transfusion requirements (2.9 ± 3.3 mL vs. 11.2 ± 6.0 mL in placebo; P < .01), diminishing the magnitude of collected blood losses (5.1 ± 2.2 g vs. 12.7 ±7.7 g in placebo; P < .05), and decreasing the mortality from the portal hypertension-related bleeding (10% vs. 60% in placebo; P < .05). In conclusion, in hypovolemic portal-hypertensive rats during a portal hypertension-related bleeding, F-180 rapidly recovers arterial pressure and decreases transfusion requirements, blood losses, and mortality. (Hepatology 2003;38:1378-1383.)
Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis
Authors: V. Bocchino, G. Bertorelli, C.P. Bertrand, P.D. Ponath, W. Newman, C. Franco, A. Marruchella, S. Merlini, M. Del Donno, X. Zhuo, D. Olivieri
Journal: Allergy (2002)
Neonatology
Authors: Ipatia Apostolidou, Nikolaos Kalpoyannis, D. Maksimovic, Z. Brajkovic, N. Vunjak, P. Ivanovski, Elizabeta Zisovska, J. Vragoterov, Irma van Straaten, Maureen Groote, J. Belopavlovic, V. Pekovic-Zrnic, A. Stokic, Dj. Maĉvanin, M. Cvejanov, T. Radunovic, B. Draškovic, A. Komarĉevic, P. G. Gamba, Z. Tchaprassian, G. F. Zanon, M. Guglielmi, G. P. Gancia, L. Bruschi, E. Polito, G. Ferrari, G. Rondini, L. J. I. Zimmermann, M. C. M. van Oosten, Paweł Kawczyński, Andrzej Piotrowski, M. Zitek, P. Pokorna, B. Buriankova, Z. Kokstein, Stefan Grosek, Gorazd Kalan, Ivan Vidmar, Janez Primožič, Iaka Lazar, Igor Sterle, Meta Derganc, Živa Zupančič, A. I. Gritsan, A. P. Kolesnichenko, E. P. Torgovtseva, I. V. Kuznetsova, Y. Bult, A. M. Schreuder, P. J. J. Sauer
Journal: Intensive Care Medicine (1996)
Priorities in the Investigation of Human Health Hazards in the Plastics and Synthetic Rubber Industries
Authors: Irving J. Selikoff
Journal: Environmental Health Perspectives (1976)

Experiences in the past decade provide guidance in selecting priorities for investigation of health hazards in chemical industries. Pride of place should be given to the experience of large industrial populations, in part simply because large numbers of people are at risk and in part because such studies are more likely to give reliable answers. This recommendation has further strength when there is community exposure as well. Parenthetically, large populations provide opportunity to study multiple factor interaction; without this, toxic potential of a single agent may be obscured. Second, investigations should be mounted when there is reason for suspicion, as with particular chemical configurations, observed organ toxicity, animal carcinogenicity, unusual clinical experience (“signal” tumors). It may be added that when agents have already been used several decades, evaluation of human experience with them is now in order, if only to document absence of toxicity. The same recommendations hold for planned introduction of new agents or widened distribution of existing ones, until we have better information concerning validity of “pretesting” programs. Major advances have been made in epidemiological methods for these investigations. These now allow us to successfully focus on small defined groups as well as to manage large populations.
Fibrosing uremic pleuritis during hemodialysis
Authors: R. Rodelas
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Abstract and Text
Authors: Jonathan Ellen, Lauren Greenberg, James Korelitz, Efrat Amitay
Journal: JAMA Pediatrics (2015)

Juliana F. W. Cohen, ScM, ScD; Scott A. Richardson, MBA; Sarah A. Cluggish, MBA; Ellen Parker, MBA, MSW; Paul J. Catalano, ScD; Eric B. Rimm, ScD
Intravascular lymphomatosis presenting with a conus medullaris syndrome mimicking disseminated encephalomyelitis
Authors: Stefan Schwarz, Saida Zoubaa, Michael Knauth, Clemens Sommer, Brigitte Storch-Hagenlocher
Journal: Neuro-Oncology (2002)

Neuro-OncologyWe describe the clinical, radiologic, and postmortem ndings of a 42-year-old man with intravascular lymphomatosis.The patient presented with a conus medullaris syndrome followed by progressive, disseminated spinal and cerebral symptoms.Disseminated encephalomyelitis was suspected due to the clinical, radiologic, and cerebrospinal uid ndings and the results of a stereotactic brain biopsy, all of which were compatible with in ammatory CNS disease.Treatment with methylprednisolone and cyclophosphamide led to a temporary remission of symptoms.The patient died 13 months after onset of symptoms.The diagnosis of disseminated intravascular lymphomatosis was established after death.
Retreatment of patients with chronic hepatitis C
Authors: Mitchell L. Shiffman
Journal: Hepatology (2002)

Significant advances have been made in the treatment of chronic hepatitis C virus (HCV) infection during the past 5 years. As a consequence, there is continuing enthusiasm for retreating patients who did not achieve sustained virological response (SVR) with previous therapy. Retreatment of non-responders to standard interferon monotherapy using interferon and ribavirin has yielded SVR rates of 12% to 15%. Retreatment with peginterferon and ribavirin has been more effective; achieving SVR rates of 34% to 40%. Retreatment of patients who relapsed after interferon monotherapy using standard interferon and ribavirin yielded SVR rates of 47%, whereas retreatment with peginterferon and ribavirin resulted in an SVR rate of about 60%. The major factors associated with a higher likelihood of an SVR after retreatment include previous relapse, previous treatment with interferon monotherapy, HCV genotypes 2 or 3, lower serum levels of HCV RNA, and having a significant decrease in HCV RNA levels during the initial course of therapy. These results help to focus retreatment with peginterferon and ribavirin on subsets of patients who are most likely to benefit. (Hepatology 2002;36:S128-S134).
Plasma lipids and urinary excretion of catecholamines in man during experimentally induced emotional stress, and their modification by nicotinic acid
Journal: Journal of Clinical Investigation (1969)

Nicotinic acid minus controls group, for + 12.3 read + 2.3 p. 1803, left column, paragraph 1, line 9, for 10)-(0.25 x 0.40 x 0.3 x 0.3 x 60 x 4.5 ) %:read 10)-(0.25 x 0.40 x 0.3 x 3 x 60 x 4.5)#
Endostatin, an antiangiogenic drug, induces tumor stabilization after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human high-grade non-Hodgkin lymphoma
Authors: Francesco Bertolini, Lisa Fusetti, Patrizia Mancuso, Alberto Gobbi, Chiara Corsini, Pier Francesco Ferrucci, Giovanni Martinelli, Giancarlo Pruneri
Journal: Blood (2000)
Abstract P136: The Effect of Exercise Training on 10-Year Atherosclerotic Cardiovascular Disease Risk in Individuals with Type 2 Diabetes
Authors: Damon Swift, Neil M Johannsen, Carl J Lavie, Conrad P Earnest, Steven N Blair, Timothy S Church
Journal: Circulation (2016)

Introduction: The American Heart Association (AHA) pooled cohort equations provide sex and race specific estimates of 10-year atherosclerotic cardiovascular disease (ASCVD) risk based on traditional risk factors, but not physical activity (PA) or fitness. The effect of exercise training on estimated ASCVD risk has not been previously evaluated, which is clinically relevant to individuals with type 2 diabetes (T2D) who have increased risk of ASCVD. The purpose of the present study is to determine the effect of aerobic (AER), resistance (RES) or combination (COMB) exercise training on 10-year ASCVD risk in individuals with T2D. Methods: The present study is an ancillary analysis of the Health Benefits of Aerobic and Resistance Training Study (HART-D). Adults with T2D (n=148) were randomized to 9 months of AER, RES, COMB exercise training or a control group (CON); 10-year ASCVD risk was calculated using the AHA pooled cohort equations based on each participants’ demographic (age, sex, race) and clinical data (high density lipoprotein, total cholesterol, systolic blood pressure/history of hypertension) and known T2D status at baseline and follow-up. Change in ASCVD risk was evaluated with an analysis of covariance with adjustment for baseline ASCVD risk. Results: Participants in the present analysis had a mean (SD) 10-year ASCVD risk of 12.2% (9.4). Baseline ASCVD risk was associated with body fat (r=-0.22, p&lt; 0.001) and duration of T2D (r=0.18, p=0.03), but not with peak VO 2 , hemoglobin A 1C , or other cardiometabolic variables (p&gt;0.05). No significant change in ASCVD risk was observed in the AERO (-0.36%, CI: -1.44 to 0.71), RES (-0.43%, CI: -1.49 to 0.63) and the COMB groups (-0.54%, CI: -1.57 to 0.49) compared to the CON (0.02%, CI: -1.26 to 1.31) group. However, in exercisers only, the change in diastolic blood pressure was associated with change in ASCVD (r=0.34, p&lt;0.001), but not change in hemoglobin A 1C , peak VO 2 , body fat mass, or other cardiometabolic risk factors (p&gt;0.05). Conclusions: The present study suggests that 9 months of exercise training did not reduce ASCVD risk predicted by the pooled cohort equations. Since exercise training is recommended by the AHA to reduce ASCVD risk especially in adults with T2D, future studies should evaluate if adding a variable that represents physical activity and/or fitness provides additional discrimination in the prediction of ASCVD.
QuickStats: Age-Adjusted Drug Overdose Death* Rates,† by State — United States, 2018§
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

DCRate signi cantly higher than U.S. rate Rate not signi cantly di erent from U.S. rate Rate signi cantly lower than U.S. rate Abbreviation: DC = District of Columbia.* Drug overdose deaths were identified using International Classification of Diseases, Tenth Revision underlying cause-of-death codes X40-X44, X60-X64, X85, and Y10-Y14
Book Review The Mechanism of the Heart and Its Anomalies . By ÉMILE Géraudel. Translated, with an Introduction, by Louis Faugères Bishop and Louis Faugères Bishop, Jr. Williams and Wilkins Company, Baltimore, 1930. Edition Limited to Five Hundred Copies, $10. pp. 266 including the index of 4 pp. Eight Chapters, 200 Illustrations.
Journal: New England Journal of Medicine (1930)
Errata: Apparent correlation between structure and carcinogenicity of phenylenediamines and related compounds
Journal: Environmental Health Perspectives (1984)

On page 267, column 1, lines 22-23, the sentence, "Of the mouse hepatocarcinogens, only 4-methoxy-1,3-phenylenediamine was also carcinogenic for other sites (i.e., hematopoietic system)' should be omitted.Also, on page 262, column 1, under 'Amount of Dosing," the units should be mg/kg diet, not ppm/day.
Erratum
Journal: JNCI Journal of the National Cancer Institute (1997)

“Association Between Human Papillomavirus Type 18 Variants and Histopathology of Cervical Cancer,” by Lizano et al. [J Natl Cancer Inst 1997;89:1227–31 (Issue 16)]. There is a discrepancy between the text on page 1229 (column 2, sentence beginning on line 20) and data shown in Table 1, B, concerning HPV18 variant 1. The information in the table is correct, and the sentence in the text should read as follows: “The other HPV18 variant (var-1) was observed in all histologic types except small-cell carcinoma.” The Journal regrets the error.
neuroendocrine tumors and cup
Authors: Marco Platania, Emilio Bajetta, Laura Catena, Mario Santinami, Roberto Patuzzo, Andrea Maurichi, Giuseppe Procopio, Sara De Dosso, Monika Ducceschi, Roberto Buzzoni, Ofer Purim, Baruch Brenner, Efrayim Idelevich, Haim Gutman, Meora Feinmesser, Rami Yosef, Gideon Mahrshak, Amir Abramovich, Aaron Sulkes, Eyal Fenig
Journal: Annals of Oncology (2007)
Systemic "allergic" vasculitis. Clinical and pathological relationships
Authors: R. P. McCombs
Journal: JAMA (1965)

A review of 72 cases of vasculitis indicated that hypersensitivity was a probable cause in the majority, but in five cases there were associated lymphoproliferative diseases. Corticosteroids controlled nearly all of the manifestations of vasculitis if administered in adequate dosage before irreparable vascular or renal damage occurred. Prolonged suppressive therapy with corticosteroids was necessary in some, but complete recovery was noted in one fourth and partial recovery in one third of the patients. Most deaths were due to renal failure within three months of onset. It is suggested that the terms periarteritis or polyarteritis nodosa be reserved for those cases with nodular arteritis and that the term systemic "allergic" vasculitis be used for those cases with only small vessel involvement; in these the prognosis is much better.
The George Washington Plan
Authors: T. M. Peery
Journal: JAMA (1969)

I wish to describe a plan having the same primary objective as the three plans previously presented, but organized entirely within an existing medical school and its related hospitals. Its primary objective is, of course, to increase the output of physicians. This plan is the outgrowth of an observation made in 1958 by our dean, John Parks, MD, that the basic science portion of the medical curriculum is really the limiting factor in the expansion of classes in most medical schools. Most medical schools are located in large cities, which have hospital facilities that are not fully used for undergraduate medical education. Clerkship opportunities can ordinarily be expanded twofold without too much difficulty. By contrast, most basic science departments have no bench space in their teaching laboratories to add a single student. To expand these facilities would, in most instances, require a major building program. And yet the classrooms and
A Manual of Histology.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Posttraumatic Stress Disorder
Authors: Lise M. Stevens, Cassio Lynm, Richard M. Glass
Journal: JAMA (2006)

Posttraumatic Stress DisorderA fter people experience a very stressful event, they may feel that they should be able to move on and "just handle it" or "get over it."Some experiences, however, are so traumatic that people have serious problems coping and functioning in their daily lives afterward.They may have posttraumatic stress disorder (PTSD).The August 2, 2006, issue of JAMA includes articles about PTSD among adults and children affected by natural disasters.This Patient Page is based on one previously published in the August 1, 2001, issue of JAMA.
Myeloid Growth Factors
Authors: Jeffrey Crawford, James Armitage, Lodovico Balducci, Charles Bennett, Douglas W. Blayney, Spero R. Cataland, David C. Dale, George D. Demetri, Harry P. Erba, James Foran, Alison G. Freifeld, Marti Goemann, Mark L. Heaney, Sally Htoy, Susan Hudock, Dwight D. Kloth, David J. Kuter, Gary H. Lyman, Laura Boehnke Michaud, Sarah C. Miyata, Martin S. Tallman, Saroj Vadhan-Raj, Peter Westervelt, Michael K. Wong
Journal: Journal of the National Comprehensive Cancer Network (2009)

NCCN Categories of Evidence and ConsensusCategory 1: The recommendation is based on high-level evidence (e.g., randomized controlled trials) and there is uniform NCCN consensus.Category 2A: The recommendation is based on lower-level evidence and there is uniform NCCN consensus.Category 2B: The recommendation is based on lower-level evidence and there is nonuniform NCCN consensus (but no major disagreement).Category 3: The recommendation is based on any level of evidence but reflects major disagreement.All recommendations are category 2A unless otherwise noted.Clinical trials: The NCCN believes that the best management for any cancer patient is in a clinical trial.Participation in clinical trials is especially encouraged.
Hand Difficulties Among Musiciansn
Authors: Fred H. Hochberg
Journal: JAMA (1983)

We describe our experience with 100 musicians in whom occupationrelated difficulties developed. The majority, pianists, experienced hand difficulties in midcareer (average age, 31 years). These were described as "pain, tightening, or weakness" of the right hand or arm or drooping of the fourth or fifth fingers. These difficulties led to loss of control (34%) or diminished facility (18%), endurance (18%), or speed (18%) while playing trills, arpeggios, or octaves requiring fast, forte finger movements. Most commonly found were inflammatory disorders of tendon or joint (45%) or disorders of motor control (24%). Less likely were entrapment of peripheral nerves and noninflammatory tendon or joint disorders. (<i>JAMA</i>1983;249:1869-1872)
SCARLATINAL NEPHRITIS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aspiration of intrathoracic abscess. Resultant acute ventilatory failure
Authors: G. S. Reeder
Journal: JAMA (1978)

Three cases illustrate that acute respiratory failure may be precipitated by spontaneous drainage of lung abscess or pleural empyema intrabronchially with diffuse aspiration of the contents bilaterally. This condition is especially hazardous if the cavity is large and the patient is debilitated or obtunded. The acute onset may mimic aspiration of gastric contents. Immediate studies of tracheal aspirate and of roentgenograms of the chest should define the aspiration of intrathoracic abscess contents as the cause of acute respiratory failure. (<i>JAMA</i>240:1156-1159, 1978)
IMPORTANT CONSIDERATIONS IN THE ADMINISTRATION OF ARTIFICIAL PNEUMOTHORAX
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pericardial Effusion
Authors: MURRAY G. BARON
Journal: Circulation (1971)

Both a pericardial effusion and a failing myocardium can produce the roentgen appearance of a large, smoothly dilated heart which shows little evidence of pulsations. The correct diagnosis is often suggested by the appearance of the hilar vessels which are usually obscured by the cardiac shadow that is enlarged by a pericardial effusion, and not by the failing heart with dilatation of its chambers. Displacement of the epicardial fat line within the cardiac silhouette can be pathognomonic for a pericardial effusion. A normal pericardial shadow outlined by epicardial and retrosternal fat lines, seen on the lateral chest film, will exclude a pericardial effusion from consideration. A conclusive diagnosis of a pericardial effusion can be made by angiocardiography.