tbuckley/cabot-search huggingface dataset:
Glossary of cardiologic terms related to physical diagnosis and history. I. Heart murmurs
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the Etiology of Sarcoidosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cat-scratch disease. Bacteria in skin at the primary inoculation site
Authors: A. W. Margileth
Journal: JAMA (1984)

Cat-scratch disease is a zoonotic infection characterized by a skin papule at the site of the scratch followed by regional lymphadenitis. Recently, small gram-negative pleomorphic bacilli were demonstrated in sections of lymph node from patients with the disease. We now report identical bacteria in the primary inoculation site of three patients with cat-scratch disease. Lymph nodes from two of these patients also contained the same bacilli. Identical bacteria in both skin and lymph nodes from these patients are further evidence that the bacilli are the cause of cat-scratch disease. In early infections, biopsy of the primary site of inoculation and demonstration of bacilli may replace excision and histologic examination of lymph node in establishing the diagnosis of cat-scratch disease. (<i>JAMA</i>1984;252:928-931)
Prospective phase II study of tumor response assessment by CT and FDG-PET/CT following 8 weekly doses of cetuximab in patients with metastatic/recurrent head and neck squamous cell carcinoma (HNSCC).
Authors: J. Ley, D. Adkins, D.I. Kuperman, B.A. Siegel, F. Dehdashti, F. Wippold, K. Trinkaus, J. Subramanian, T. Rachocki
Journal: Journal of Clinical Oncology (2010)

5553 Background: The likelihood of tumor response (CR/PR) to cetuximab as assessed by CT in patients with metastatic/recurrent HNSCC was 13%; however, stable disease occurred in an additional 33% (Vermorken JCO, 2007). Tumor response to cetuximab in patients with HNSCC has not been characterized by FDG-PET/CT, nor have PET results been correlated with CT results. Methods: The primary objective of this trial was to compare the maximum standardized uptake value (SUVmax) for FDG of up to 3 target tumor sites at baseline and then after 8 weekly doses of cetuximab (400 mg/m2 loading dose, 250 mg/m2 weekly doses). A secondary objective was to correlate the overall tumor metabolic response (MR) as assessed by FDG-PET/CT with the anatomic tumor response by RECIST as assessed by CT. Standard criteria were used to determine MR by FDG-PET/CT (complete MR [CMR]=complete resolution; partial MR [PMR]=20% or more decrease in SUVmax; progressive metabolic disease [PMD]=new lesions, 20% or more increase in SUVmax, or increased SUV of nontarget lesions; stable MD [SMD]=other). Results: To date, 11 patients were enrolled of whom 6 were evaluable for the objectives and 5 were non-evaluable because of early progressive disease (3), infection, or respiratory failure. Changes in target lesion SUVmaxare shown in the table. After 8 weekly doses of cetuximab, all 6 patients had stable disease by CT, whereas two patients had stable disease by FDG-PET/CT and 4 patients had PMD by FDG-PET/CT. Conclusions: The early results of this trial suggest a poor correlation of tumor response assessment by CT and FDG-PET/CT imaging in patients with metastatic/recurrent HNSCC treated with cetuximab. Evaluable FDG-PET/CT CT Patients Target lesions Nontarget lesions (NTL) MR Target lesions RECIST Baseline SUVmax SUVmax at 8 wks 1 9.77 7.58 6.63 8.9 6.9 8.32 New lesions and progression of NTL PMD 11% ↓ Stable 2 * * New lesions PMD 11% ↓ Stable 3 8.9 7.4 Progression of NTL PMD 8% ↑ Stable 4 5.7 8.2 Stable PMD 14% ↓ Stable 5 8.23 7.39 6.98 6.71 6.06 9.67 Stable SMD 7% ↑ Stable 6 14.4 10.3 Stable SMD 2% ↓ Stable * Lesions were less than 1.5 cm = nonevaluable for primary objective. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration ImClone Systems ImClone Systems ImClone Systems
Contribution à l'étude radiographique du sein normal et pathologique
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Complications of Blood Transfusion.
Authors: Lawrence E. Young
Journal: Annals of Internal Medicine (1964)

s1 February 1964Complications of Blood Transfusion.Lawrence E. Young, M.D., F.A.C.P.Lawrence E. Young, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-326_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvery blood transfusion subjects the patient to hazards, some of which can be minimized by exercising necessary precautions while others cannot be reduced by methods now available. The following complications will be considered from the standpoints of incidence, pathogenetic mechanisms, and prevention: destruction of donated or autogenous red blood cells, isoimmunization with subsequent risk of hemolytic disease in offspring and increased risk of hemolytic reactions after future transfusions, reactions initiated by antibodies to leukocytes and platelets, thrombocytopenia after transfusion of large volumes of stored blood, circulatory overload, hepatitis, and toxic reactions due to use of contaminated blood.The risks of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 326-326KeywordsAntibodiesBlood cellsBlood transfusionBlood volumeForecastingHepatitisPathogensPlateletsRed blood cells Issue Published: 1 February 1964 PDF DownloadLoading ...
Ultrastructural location of human hepatocyte growth factor in human liver
Authors: H Sakaguchi
Journal: Hepatology (1994)

Human hepatocyte growth factor has been purified from the plasma of patients with fulminant liver failure, but where this factor is produced in organs or cells of subjects with liver diseases is unknown. Therefore, we used a monoclonal antibody to human hepatocyte growth factor to stain cells in three normal and 29 diseased liver tissues by immunohistochemical techniques. By light microscopy, the immunostained cells seemed to be polymorphonuclear leukocytes because of their segmented nuclei. Some biliary epithelial cells also were stained. Electron microscopy confirmed that the immunostained cells with segmented nuclei were polymorphonuclear leukocytes and that the stained grains were on the membranes of rough endoplasmic reticulum, around specific or azurophilic granules and in the cell sap. Stained grains in the biliary epithelial cells were found sporadically on the inside and outside of the membranes of rough endoplasmic reticulum near the nuclei. Human hepatocyte growth factor is now known to be the same protein as scatter factor and tumor cytotoxic factor, both of which are produced by human fibroblasts in culture, but our results suggest that polymorphonuclear leukocytes in diseased livers are one cellular source of circulating human hepatocyte growth factor. The immunostaining properties of biliary epithelial cells in diseased livers also suggest that the cells produce and secrete human hepatocyte growth factor. (HEPATOLOGY 1994;19:1157–1163.)
American Practice of Surgery. A Complete System of the Science and Art of Surgery by Representative Surgeons of the United States and Canada.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pregnant Grandmas? Blame Oral Contraceptives
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AIDS research coordination abetted
Authors: P. Cotton
Journal: JAMA (1994)

REFORM with "teeth" is getting a grip on federal AIDS research efforts. The National Institutes of Health (NIH) Office of AIDS Research (OAR) now has much more power to coordinate research efforts, thanks to language in last year's NIH Revitalization Act requiring that all of the NIH's $1.3-billion budget for AIDS research go through the OAR for distribution to the various institutes. The law gives the OAR authority to allocate funds that are not already committed to ongoing projects, about 20% of the AIDS research budget each year, according to priorities set by the OAR with guidance from an advisory council of outside experts. (Actual grants and contracts, however, will still be made by the individual institutes.) It also gives the OAR, like the similary NIH-funded National Cancer Institute, a bypass budget, with requests going directly to the President of the United States instead of through the NIH or other
Continuing medical education. Impact on emergency room burn care
Authors: B. S. Linn
Journal: JAMA (1980)

The impact of continuing education in emergency room burn care was evaluated in a 20-hospital controlled study. The process of care provided by 298 physicians for 2,492 treated and released patients and 172 admitted patients was significantly improved in experimental hospitals where training had been given compared with control hospitals. Outcomes of care, such as mortality, morbidity, compliance with medical regimens, and satisfaction with care, were significantly correlated with process. Two outcomes were influenced significantly between experimental and control patients. In the treated and released group, experimental patients complied more frequently with medical regimens. In the admitted group, experimental patients had fewer early complications from their burns. The study demonstrates that practice of physicians can be altered favorably by continuing education; however, there is still room for much improvement in emergency medical services. (<i>JAMA</i>244:565-570, 1980)
Clinical Examination of Urine with an Atlas of Urinary Deposits. Including Forty-one Original Plates. Mostly Colored.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mallory body induction in drug-primed mouse liver
Authors: Q Yuan
Journal: Hepatology (1996)

The aim of this study was to determine the various factors that are involved in the induction of Mallory body (MB) formation. A model was developed where MB formation was induced by refeeding either of the drugs griseofulvin or diethyl 1,4-dihydro-1,4,6-trimethyl-3,5- pyridinedicarboxylate (DDC). Mice were fed the drugs for 5 months, followed by withdrawal of the drugs for 1 month (drug-primed livers). The drugs were refed for 1,3,5,7, or 11 days. Early MBs first appeared as small, enlarged aggregates of filaments in the perinuclear or pericanalicular location on the third day of refeeding. Mature MBs appeared on the fifth day of refeeding. MBs reached maximum concentration on day 5 of refeeding. Western blots showed a progressive increase in the cytokeratin proteins (CK49 and CK55) and actin while refeeding the drugs. Liver cell regeneration, as indicated by the percent of proliferating cell nuclear antigen (PCNA)-positive nuclei, increased on the third day of refeeding. However, there was no correlation between the frequency of MBs and the percent of PCNA- positive nuclei. It is concluded that MB formation is not related to the liver cell regeneration response to injury but rather involves a separate regulation pathway. The MBs were heavily ubiquitinated and were associated with increased ubiquitin-protein conjugates as indicated by Western blotting, suggesting that ubiquitinization of cytokeratin protein are involved in the formation of MB aggregation.
Abstract 1620: Elucidating metastatic signaling networks in TNBC by investigating RKIP-regulated kinome
Authors: Ali E. Yesilkanal, Casey Frankenberger, Daniel C. Rabe, Gary L. Johnson, Marsha Rosner
Journal: Cancer Research (2016)

Abstract Metastatic progression of tumors is the major cause of death in patients with triple negative breast cancer (TNBC), the most aggressive subtype of breast cancer. However, since metastasis is a multi-step process, unraveling its complexity is a major challenge. One effective way of tackling this question is to study natural blockers of the metastatic process, metastasis suppressors, and identify the mechanisms by which they regulate metastasis. Raf kinase inhibitory protein (RKIP), a protein that regulates kinase activity, is a suppressor of TNBC metastasis. Although RKIP inhibits the activity of key kinases such as Raf-1, GRK2, NIK/IKK in cultured cells, the kinase targets of RKIP in tumors are not known. To address this question, we used a mass spectrometry approach involving inhibitor-conjugated beads to identify kinases that are down-regulated by RKIP in human TNBC xenograft tumors. Our results identified novel targets of RKIP whose kinase activity is either down-regulated or up-regulated by RKIP. We used bioinformatics analysis to build RKIP-regulated signaling networks based upon RKIP-induced changes in kinase activity and related gene expression. Elucidating RKIP function at a systems level reveals the interplay between key metastatic signaling cascades, particularly in relation to cell migration and invasion, and can potentially identify novel anti-metastatic target combinations in TNBCs. Citation Format: Ali E. Yesilkanal, Casey Frankenberger, Daniel C. Rabe, Gary L. Johnson, Marsha Rosner. Elucidating metastatic signaling networks in TNBC by investigating RKIP-regulated kinome. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1620.
TULAREMIA
Authors: TURNER S. SHELTON
Journal: JAMA (1925)

Tularemia was discovered by McCoy and Chapin in 1912 as an epidemic in ground squirrels in Tulare County, California. Although this infection has prevailed in these squirrels until the present, no cases in human beings have been reported from California. Later, Wherry and Lamb isolated the germ from rabbits, during an epidemic in Indiana. Not until 1922 was the disease described in man, when Dr. Edward Francis described it and called it "tularemia, a new disease in man." Since that time, there have been reported about 300 cases in Utah, Montana, Wyoming, New Mexico, North Carolina, and Washington, D. C. Six cases in laboratory workers were reported in Washington, D. C., three in Montana and three in the Lister Institute, London. In all three of these laboratories, every worker experimenting with tularemia contracted it. The only cases that I can find reported in the Southeast is one in Charlotte, N.
Endothelial lipase is a major determinant of HDL level
Authors: Tatsuro Ishida, Sungshin Choi, Ramendra K. Kundu, Ken-ichi Hirata, Edward M. Rubin, Allen D. Cooper, Thomas Quertermous
Journal: Journal of Clinical Investigation (2003)

A new member of the lipase gene family, initially termed endothelial lipase (gene nomenclature, LIPG; protein, EL), is expressed in a variety of different tissues, suggesting a general role in lipid metabolism. To assess the hypothesis that EL plays a physiological role in lipoprotein metabolism in vivo, we have used gene targeting of the native murine locus and transgenic introduction of the human LIPG locus in mice to modulate the level of EL expression. Evaluation of these alleles in a C57Bl/6 background revealed an inverse relationship between HDL cholesterol level and EL expression. Fasting plasma HDL cholesterol was increased by 57% in LIPG–/– mice and 25% in LIPG+/– mice and was decreased by 19% in LIPG transgenic mice as compared with syngeneic controls. Detailed analysis of lipoprotein particle composition indicated that this increase was due primarily to an increased number of HDL particles. Phospholipase assays indicated that EL is a primary contributor to phospholipase activity in mouse. These data indicate that expression levels of this novel lipase have a significant effect on lipoprotein metabolism.
Differences in dobutamine and adenosine coronary flow reserve and their clinical implications Rohan Jagathesan, Edward Barnes, Ornella Rimoldi, Roger J. C. Hall, Rodney A. Foale, Paolo G. Camici. MRC Clinical Sciences Centre, ICSM, London, United Kingdom, St Marys Hospital, ICSM, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)