tbuckley/cabot-search huggingface dataset:
Effect of pesticide exposure on HER-2/neu and CD117 overexpression in patients with extensive stage small cell lung carcinoma (ESSCLC)
Authors: A. Potti, A. K. Ganti, M. Koch, S. Kargas
Journal: Journal of Clinical Oncology (2004)

9629A Background: In previous reports, the rate of detection of HER-2/neu and CD117 (c-KIT) overexpression in SCLC has varied widely; between 5–35% and 21–70% respectively. Methods: To evaluate the relationship, if any, between pesticide exposure and overexpression of HER-2/neu and CD117 in extensive stage small cell lung cancer (ESSCLC), we identified patients with ESSCLC and assessed pesticide (herbicide and insecticide) risk by personal interviews using a predetermined questionnaire. An exposure index (hours/day × days/year × years) ≥ 2400 hours was considered as 'exposed.' HER-2/neu overexpression was evaluated on archival tissue using the DAKO Hercep test, and CD117 testing was performed using immunohistochemistry (A4052 polyclonal antibody). Results: 193 ESSCLC patients were identified during the study period. Pesticide exposure data could be obtained on 174 patients (84 females and 109 males) with a mean age of 68.5 years. 53/174 (30.4%) revealed HER-2/neu overexpression. Similarly, 54/174 (31.03%) specimens showed CD117 overexpression by IHC. On multivariate analysis, HER-2/neu overexpression was associated with diminished survival (p < 0.001). In comparison, CD117 expression did not have prognostic value (p = 0.025) in our study population. 41/53 (77.4%) patients with HER-2/neu overexpression and 47/121 patients without overexpression (38.8%) were exposed to pesticides. Interestingly, patients with a history of pesticide exposure had a higher risk of having HER-2/neu overexpression (odds ratio: 5.38; p < 0.01, 95% CI: 2.5–11.2). Among the cohort tested for CD117, 29/54 (53.7%) patients with CD117 overexpression and 59/120 (49.2%) patients without CD117 overexpression had evidence of pesticide exposure (odds ratio: 1.18; p = 0.12). Conclusions: Pesticide exposure seems to affect HER-2/neu overexpression but does not seem to be associated with overexpression of CD117. Future studies are needed to determine specific pesticide(s)/pesticide components that are responsible for HER-2/neu overexpression seen in ESSCLC, and to validate our findings in other solid tumors that overexpress HER-2/neu.
Malpractice
Authors: James M. Vaccarino
Journal: JAMA (1977)

Malpractice, for all intents and purposes, is ordinary negligence or carelessness. By legal definition, it is an unintentional act; that is, you cannot form the intent to commit an act of ordinary negligence. You may be intentionally careless, but such act would not come within the definition of ordinary negligence or malpractice. Rather, it would be categorized as willful and reckless misconduct, and I can assure you that this distinction is more than a paper one if for no other reason than the substantially greater amount of monetary damages awarded in the latter case. If you cannot form the intent to commit an act of ordinary negligence then, conversely, it is logical and correct to postulate that you cannot, by an act of the will, prevent ordinary negligent conduct. The act of ordinary negligence which will occur with statistical surety in a random fashion in all our daily lives can only be prevented by diligent conduct—by the practice of good medicine. You assure yourself that good medicine is practiced by participating in ongoing medical education programs and continuous association with those persons and practices which will maintain your intellectual capacity. Worrying about the occurrence of acts of negligence is of no value and is often harmful.
Fine Structural Changes of the Liver.
Authors: H. Popper
Journal: Annals of Internal Medicine (1963)

s1 April 1963Fine Structural Changes of the Liver.H. Popper, M.D., F.A.C.P., F. Schaffner, M.D., F.A.C.P.H. Popper, M.D., F.A.C.P.Search for more papers by this author, F. Schaffner, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-725_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFine structural techniques permit recognition of the abnormal reaction of living cells and development of a tentative organelle pathology. Conventional liver cell injury, as in viral or alcoholic hepatitis, is associated with alterations of the organelles responsible for specific synthetic or detoxifying functions of the liver cell, the endoplasmic reticulum, and for energy provision, the mitochondria. Cholestasis is reflected in alteration of the bile secretory mechanism consisting of biliary canaliculi, Golgi apparatus, and lysosomes. Pigment disorders are mirrored in changes of lysosomes, while alteration of sinusoidal plasma membrane is associated with enzyme release. Hepatocellular death induces panmesenchymal proliferation including macrophagic,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y. (BS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDesalination by Osmosis-Reverse Osmosis Couple 1 April 1963Volume 58, Issue 4Page: 725-726KeywordsAlcoholicsBileBlood plasmaCellsEnzymesHepatitisLiverLysosomesMitochondria Issue Published: 1 April 1963 PDF DownloadLoading ...
ANHYDREMIA AND FEVER
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract MP11: Elevated High Sensitivity C-Reactive Protein as a Risk Marker of the Attenuated Relationship Between Serum Cholesterol and Coronary Heart Disease at Older Age - Atherosclerosis Risk in Communities Study
Authors: Seamus Whelton, Probal Roy, Brad Astor, Lin Zhang, Ron Hoogeveen, Christie Ballantyne, Josef Coresh
Journal: Circulation (2013)

Introduction: The relationship between serum cholesterol and coronary heart disease (CHD) risk is attenuated at older age, making it difficult to estimate risk in this age group. Hypothesis: We hypothesized that high sensitivity C-reactive protein (hs-CRP) would identify two subgroups of older individuals (≥65 years): one in whom cholesterol is less predictive of CHD and one in whom it is equally predictive compared to younger individuals. Methods: We calculated crude incident rates per 1,000 person-years and used adjusted Cox proportional hazards models to analyze cholesterol as a predictor of CHD in 8,947 participants with no known history of CHD who were stratified by age (53-64 or 65-75 years) and hs-CRP level (&lt;2 or ≥2 mg/L) at baseline. Results: Among younger participants, total serum cholesterol was significantly associated with an increased risk of CHD regardless of hs-CRP group HR 1.39 (95% CI 1.20-1.61) for hs-CRP &lt;2 mg/L and HR 1.37 (95% CI 1.22-1.53) for hs-CRP ≥2 mg/L. Among older participants with a low hs-CRP, total cholesterol had a similar association with CHD, HR 1.46 (95% CI 1.24-1.71), as in younger individuals. In contrast, among older individuals with higher hs-CRP, the association of CHD with total cholesterol was attenuated, HR 1.14 (95% CI 1.00-1.29), p-value for interaction = 0.02. Similar trends were observed between age groups and hs-CRP categories for LDL cholesterol. Conclusions: Among individuals aged 65-75 years, the association of cholesterol with CHD was strong in those with a low hs-CRP and weak in those with an elevated hs-CRP. Thus, in addition to its use as a risk factor, an elevated hs-CRP could be useful for stratifying the elderly population to aid in the interpretation of serum cholesterol in the prediction of subsequent CHD risk.
Zinc for pancreatic diagnoses
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Books In Brief
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Veterans Administration Coronary Cooperative Study. Cooperating vs noncooperating hospitals
Authors: J. S. Carey
Journal: JAMA (1979)

THE DEBATE on the merits of coronary artery bypass continues on in editorial pages, most recently in<i>JAMA</i><sup>1</sup>and in the<i>American Journal of Cardiology</i>.<sup>2</sup>The debate was initiated by Eugene Braunwald, MD, in September 1977, when he suggested that "coronary arteriography is not always resisted vigorously" by practicing physicians caring for patients with angina pectoris. Braunwald<sup>3</sup>also said that a more insidious problem is that an industry has been built around the coronary artery bypass procedure. Dr Braunwald's comment was based on a preliminary report of a Veterans Administration Cooperative Study, which suggested that in male veterans with chronic stable angina, coronary artery bypass surgery did not prolong survival. This report has now been disputed by its own participants<sup>4</sup>and by several nonparticipating hospitals.<sup>5-7</sup>Wadsworth VA (Los Angeles) and San Francisco VA hospitals, both of which dropped out of the cooperative study in 1972,
LUNATE OSTEOMALACIA
Authors: EDWARD S. BLAINE
Journal: JAMA (1931)

A peculiar lesion of the lunate or semilunar bone of the wrist is being encountered with increasing frequency, a fact that has stimulated the interest of a number of roentgenologists and is the incentive for this presentation. Having encountered several of these cases, I present the results of a study of various factors in this unusual lesion. Kienböck,<sup>1</sup>in 1911, first described the roentgen observations in this condition, and on this account the lesion is frequently called "Kienböck's disease." Köhler,<sup>2</sup>in his book on roentgenology, prefers to call it "secondary post-traumatic malacia." Others, among them Baum,<sup>3</sup>Frenkel-Tissot,<sup>4</sup>Hering,<sup>5</sup>Kautz,<sup>6</sup>and Henderson,<sup>7</sup>have written on the subject, using variants in terminology according to their individual points of view as to causative factors and pathologic conceptions. This lack of uniformity of terminology is tending to some confusion in classification. At the present moment authorities are
Live attenuated rubella virus vaccine given in an orphanage just prior to a rubella epidemic
Authors: R. Detels
Journal: JAMA (1969)

Rubella virus vaccine (attenuated strain HPV-77) caused no reactions and showed no communicability when given to 14 Chinese orphans 2 to 6 years of age. Although the proportion of children demonstrating hemagglutination inhibition antibody by 39 days after immunization was low (7 of 12), protection from infection was demonstrated when a rubella epidemic swept the orphanage. Rubella developed in only 1 of 14 children 2 1/2 months after immunization while there were 20 cases of rash among 55 nonimmunized children of the same age. Results of this study suggest that the vaccine does not alter the disease in persons already in the incubation period of natural rubella.
Islam with the internet could do much to prevent disease
Authors: A. Husseini, R. E LaPorte
Journal: BMJ (2001)

Mercury sphygmomanometers: disposal has far reaching consequencesEditor-The papers by O'Brien and Beevers et al have documented the trend away from the use of the mercury sphygmomanometer. 1 2 But the ethical, legal, economic, and public health consequences associated with their disposal have not been so well documented.This lack of advice is surprising since mercury has well known toxic properties.Haphazard disposal of mercury inevitably leads to environmental recycling and bioconcentration, with ecological damage at best and human poisoning at worst. 3 The Special Waste Regulations 1996 classify mercury and waste material containing more than 3% mercury as special waste and require extensive documented control of, and the use of approved contractors for, each stage of the disposal process.Noncompliance can result in a major fine, together with a custodial sentence.Although technically only the mercury component is special, it would not be safe for staff to break sphygmomanometers open to access the mercury in uncontrolled conditions.In addition, we considered it likely that standard mercury containing sphygmomanometers used in general prac-tice in England and Wales would contain more than 3% mercury and should therefore be considered special waste.We obtained four intact mercury sphygmomanometers from a general practitioner's surgery and drained and weighed the mercury under laboratory conditions.Each contained more than 3% mercury (average 6.5%).The NHS must develop a policy for the storage and ultimate disposal of retired mercury sphygmomanometers that accords with the Special Waste Regulations 1996.Data from Birmingham health authority show that more than 30 000 mercury sphygmomanometers are still in active use by general practitioners in the UK.If plans are not made to dispose of these sphygmomanometers safely, some 1800 kg of mercury could enter the environment.The contamination that would result from the haphazard disposal of all mercury sphygmomanometers used in the NHS would be much greater, and the volumes involved suggest that collection and recycling may be commercially viable.What should general practitioners, hospitals, and other NHS trusts do?Expecting each to negotiate a suitable system of collection and disposal would be burdensome, inefficient, and impractical, although it is their legal responsibility to do so.We are working with the environment agency in our region to develop an approved scheme that will reduce the bureaucratic demands on individual practices while protecting them from statutory action and, at the same time, provide a safe, efficient, and cost effective storage, transport, and disposal service.
Behçet's Disease
Authors: ROBERT E. CURRAN
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 February 1972Behçet's DiseaseROBERT E. CURRAN, M.D.ROBERT E. CURRAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-2-332 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the October issue O'Duffy, Carney, and Deodhar (Ann Intern Med75:561-570, 1971) present cases as examples of Behçet's disease that provoke concern about its definition. Their report is unique for the predominance of female cases. For example, the 8 references cited that include 10 or more cases contain 80% males. This includes a dermatology source (Reference 7) with 95% males (19 of 20 cases), ophthalmology sources (References 12, 13, and 30) with 90% males (156 of 175 cases), and medicine-rheumatology sources (References 8, 11, 17, and 18) with 66% males (87 of 132 cases). The latter...References1. GUMPEL J: Trigeminal sensory neuropathy in connective-tissue disease. N Engl J Med 282:514, 1970 CrossrefMedlineGoogle Scholar2. FORDSIEKERT RR: Central nervous system manifestations of periarteritis nodosa. Neurology 15:114-122, 1965 CrossrefMedlineGoogle Scholar3. KALBIANCHALLIS VM: Behçet's disease: report of twelve cases with three manifesting as papilledema. Am J Med 48:823-829, 1970 CrossrefGoogle Scholar1. POLYCHRONAKOSSARAKOTSIS DG: Das Adamantiadis-Behçet-Syndrom. Klin Monatsbl Augenheilkd 154:336-341, 1969 MedlineGoogle Scholar2. DOWLINGDUDGEONPERKIUS GJE: Discussion on Behçet's disease. Proc R Soc Med 54:101-107, 1961 CrossrefMedlineGoogle Scholar3. MASONBARNES RC: Behçet's syndrome wth arthritis. Ann Rheum Dis 28:95-103, 1969 CrossrefMedlineGoogle Scholar4. BIETTIBRUNA GF: An ophthalmic report on Behçet's disease, in Symposium on Behçet's Disease, edited by MONACELLI M, NAZZARO P. Basel, S. Karger AG, 1966, pp. 79-110 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Wilmer Institute The Johns Hopkins Hospital Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMuscular involvement in Beh çet's disease: Case report and review of the literatureVasculitic NeuropathyPediatric onset of behcet's syndrome with myositis: case report and literature review illustrating unusual featuresMononeuritis multiplex in incomplete Behcet's disease: A case report and the review of the literatureNeurogenic muscular atrophy in Behcet's diseaseThe myopathology of Behçet's diseaseSindrome de behçet con afeccion pulmonar. Presentacion de un caso y revision de la literaturaSensory Symptoms in Behçet’s Syndrome 1 February 1972Volume 76, Issue 2Page: 332-333KeywordsDermatologyOphthalmology Issue Published: 1 February 1972 PDF DownloadLoading ...
THE PURPOSE AND NATURE OF ACUTE INFLAMMATION.
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase I study of LDE225 in combination with gemcitabine and nab-paclitaxel in patients with metastasized pancreatic cancer
Authors: K. Lee, R.J. Molenaar, R. Klaassen, M.F. Bijlsma, M.J. Weterman, D.J. Richel, M. Wymenga, H.W.M. van Laarhoven, J.W. Wilmink
Journal: Annals of Oncology (2017)
Metabolism of Phenol and Hydroquinone to Reactive Products by Macrophage Peroxidase or Purified Prostaglandin H Synthase
Authors: Michael J. Schlosser, Robert D. Shurina, George F. Kalf
Journal: Environmental Health Perspectives (1989)

Macrophages, an important cell-type of the bone marrow stroma, are possible targets of benzene toxicity because they contain relatively large amounts of prostaglandin H synthase (PHS), which is capable of metabolizing phenolic compounds to reactive species. PHS also catalyzes the production of prostaglandins, negative regulators of myelopoiesis. Studies indicate that the phenolic metabolites of benzene are oxidized in bone marrow to reactive products via peroxidases. With respect to macrophages, PHS peroxidase is implicated, as in vivo benzene-induced myelotoxicity is prevented by low doses of nonsteroidal anti-inflammatory agents, drugs that inhibit PHS. Incubations of either 14C-phenol or 14C-hydroquinone with a lysate of macrophages collected from mouse peritoneum (greater than 95% macrophages), resulted in an irreversible binding to protein that was dependent upon H2O2, incubation time, and concentration of radiolabel. Production of protein-bound metabolites from phenol or hydroquinone was inhibited by the peroxidase inhibitor aminotriazole. Protein binding from 14C-phenol also was inhibited by 8 microM hydroquinone, whereas binding from 14C-hydroquinone was stimulated by 5 mM phenol. The nucleophile cysteine inhibited protein binding of both phenol and hydroquinone and increased the formation of radiolabeled water-soluble metabolites. Similar to the macrophage lysate, purified PHS also catalyzed the conversion of phenol to metabolites that bound to protein and DNA; this activation was both H2O2- and arachidonic acid-dependent. These results indicate a role for macrophage peroxidase, possibly PHS peroxidase, in the conversion of phenol and hydroquinone to reactive metabolites and suggest that the macrophage should be considered when assessing the hematopoietic toxicity of benzene.