tbuckley/cabot-search huggingface dataset:
FRI0395 Effect of Rituximab on Different Isotypes of Serum Immunoglobulins in Patients with Sle
Authors: V. Reddy, L. Martinez, D. Isenberg, G. Cambridge, M. Leandro
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The impact of rituximab therapy on different compartments of the immune system may inform as to the possible clinical response and also maintenance of protective immunity. We conducted a retrospective study of serum IgM, IgG and IgA in 57 patients with SLE, following the first cycle of B cell depletion therapy based on rituximab (RTX). <h3>Methods</h3> Serum Ig levels (IgA, IgG and IgM) were assessed at baseline (before first infusion of RTX) and at 1, 2, 6, 9 and 12 months after the first cycle of RTX in 57 patients with SLE. Paired t-test and Spearman9s rank correlation were used to analyse changes in serum Ig levels and to analyse correlations, respectively. <h3>Results</h3> Median baseline serum IgA level was 2.9g/L, which fell by a mean 6% and 10% (p&lt;0.05), at 1 and 2 months after RTX but was similar to baseline at 12 months. IgA levels at baseline showed a positive correlation with IgA levels at all time points (r<sup>2</sup>≥0.5, p&lt;0.0001 for all). Median baseline serum IgG level was 13.9g/L, which was significantly reduced (p&lt;0.05) (means of 7%, 11%, 5% and 7% at 1, 2, 6, and 9 after RTX) but levels were similar to baseline at 12 months. Median baseline serum IgM levels were 1.0g/L, which reduced by means of 13%, 18%, 17%, 29% and 18% at 1, 2, 6, 9, and 12 months respectively (p&lt;0.005 for all). Serum IgG levels at 12 months either reduced (group1) or increased (group2) from baseline. Interestingly, there was a significant difference in baseline IgG levels between the two groups with a median level of 17.24g/l and 10.7g/l (p=0.0005) for group 1 and 2, respectively. Baseline IgG levels positively correlated with IgG levels at all time-points (r<sup>2</sup>≥0.6, p&lt;0.005 for all). However, there was no difference in IgG levels at 12 months between the two groups. There was a significant difference in baseline IgM levels between the group of patients who had IgM levels &lt;0.4 at 12 months and those who did not, median levels of 0.48 and 1.05g/l, respectively. There was no correlation between absolute numbers of CD19+cells at baseline and serum Ig levels or %change in Ig levels at any time-points. <h3>Conclusions</h3> Our results reveal a disparity in changes in IgA, IgG and IgM levels following rituximab treatment in SLE. Disease-associated defects in B cell biology particularly accessory cell and T-cell interactions associated with B cell survival and class-switch may, at least in part, account for this disparity. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4559
Refraction, Including Muscle Imbalance and the Adjustment of Glasses.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Carcinogenicity in Mice and Rats of Heterocyclic Amines in Cooked Foods
Authors: Hiroko Ohgaki, Hirokazu Hasegawa, Tamami Kato, Miki Suenaga, Mikiyo Ubukata, Shigeaki Sato, Shozo Takayama, Takashi Sugimura
Journal: Environmental Health Perspectives (1986)

Carcinogenicities of mutagenic heterocyclic amines in cooked foods have been tested in CDF1 mice and F344 rats of both sexes. Eight heterocyclic amines--Trp-P-1, Trp-P-2, Glu-P-1, Glu-P-2, MeA alpha C, A alpha C, IQ, and MeIQ--were given to mice and/or rats at 0.02 to 0.08% in the diet continuously. In mice, all heterocyclic amines tested were demonstrated to be carcinogenic. Hepatocellular carcinomas were induced in a high incidence in all groups treated with heterocyclic amines. Hemangioendothelial sarcomas were also induced by Glu-P-1, Glu-P-2, MeA alpha C, and A alpha C. Most hemangioendothelial sarcomas were located in the interscapular brown adipose tissue. In mice given IQ, forestomach and lung tumors were also observed in a high incidence. Carcinogenicity tests on MeIQ are ongoing, and interim data by week 83 show that MeIQ also induces forestomach tumors in addition to liver tumors. In rats, hepatocellular carcinomas were induced by Trp-P-1, Glu-P-1, Glu-P-2, and IQ. In rats given Glu-P-1, Glu-P-2, and IQ, adenocarcinomas in the small and large intestines, squamous cell carcinomas in the Zymbal gland and clitoral gland were also observed in a high incidence.
RNA Editing
Authors: L. Simpson
Journal: Annual Review of Neuroscience (1996)

RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum, (c) the C-to-U substitution editing of the mammalian apoB mRNA, (d)a similar C-to-U substitution editing of mRNAs in higher plant mitochondria and chloroplasts and in tRNAs of marsupials and rats, (e) a diverse nucleotide substitution editing of tRNAs in Acanthomoeba mitochondria, and (f) the A-to-I type of editing found in the mammalian glutamate receptor subunits. These diverse phenomena involve several different enzymatic mechanisms. In several cases, duplex RNAs with internal or external guide sequences help determine the site specificity of editing. The A-to-I editing observed in RNAs encoding non-NMDA glutamate receptor subunits may be due to the actions of a double-stranded RNA-specific adenosine deaminase that is widespread in higher organisms. Although the function of many RNA editing events is unclear, the biological importance of RNA editing in other systems may prove as significant as the nucleotide modifications regulating the cation selectivity and electrophysiological profiles elaborated by non-NMDA glutamate receptors in the mammalian brain.
Non-Hodgkin lymphomas
Authors: S. E. Jones
Journal: JAMA (1975)

THE TERM "non-Hodgkin lymphomas" is applied to a group of diverse neoplasms that arise in the reticuloendothelial system. Brief summaries of two commonly encountered types of non-Hodgkin lymphoma—diffuse histiocytic lymphoma and nodular, lymphocytic, poorly differentiated lymphoma (Rappaport et al<sup>1</sup>classification)—illustrate some of the variability of features and natural history between types. Diffuse histiocytic lymphoma, which accounts for approximately 30% of all non-Hodgkin lymphomas, is associated with a generally poor prognosis (median survival, about one year). It occurs more frequently in men than in women, but in both sexes there is a broad age distribution. Severe impairment of cell-mediated immunity, constitutional symptoms (fever, night sweats, and weight loss), and intra-abdominal involvement at the time of initial presentation are common. Diffuse histiocytic lymphoma is more likely to involve tissue in the Waldeyer tonsillar ring, the gastrointestinal tract, or other extranodal sites, but one third of these lymphomas are quite localized initially and
A System of Physiological Therapeutics. A Practical Exposition of the Methods, Other Than Drug-Giving, Useful in the Prevention of Disease and in the Treatment of the Sick.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cortisone Therapy
Authors: O. Savage
Journal: Annals of the Rheumatic Diseases (1958)

This book is undoubtedly a classic in the literature of the rheumatic diseases.It is based on a detailed study of 293 patients with rheumatoid arthritis, with clinical and laboratory data obtained according to a set plan, which was initiated in 1929 and which has been carried out with meticulous care.The previous literature is reviewed, pointing out that the term "rheumatoid arthritis" was introduced by Sir A. B. Garrod, and that his son, A. E. Garrod, published in 1890 a study of 500 cases, using control data, and giving figures for the frequency of a family history, the age and sex distribution, the aetiological significance of emotional disturbances and the influence of the menopause.The present study is a wider up-to-date record of the same type using modem methods of investigation.In discussing the diagnostic criteria used, the authors have covered the differential diagnosis of the disease in a comprehensive manner.They admit the difficulty in some cases of a clear-cut distinction between the later changes of rheumatoid and degenerative arthritis.The inclusion in the series of cases of ankylosing spondylitis is explained, but will be regretted in this country where it is considered to be a separate disease.The known high familial incidence of this condition undoubtedly alters the figures in this series, though the authors state that no conclusion can yet be drawn as to the relative influence of environment, contagion or heredity.Careful analyses are made of the effect of other illnesses, operations, injuries, occupation, and the menopause, and are compared with control material.The mode of onset and constitutional symptoms have been studied in detail and the results are of the greatest interest.Laboratory investigations have been extensive and the findings are most valuable.This detailed description of the disease by three dis- tinguished clinicians from the Massachusetts General Hospital, backed by statistical evidence compared with a control series, is one of the most authoritative studies yet published.We are promised a further report on the life history of the disease and possibly one on rational treatment.These will be awaited eagerly by all phy- sicians interested in rheumatoid arthritis.OSWALD
BOOK REVIEWS
Journal: Circulation (1959)

This volume is an authoritative statement of our knowledge of the physiologic changes of pregnancy, the effects of the various types of heart disease, and the diagnosis and detailed treatment of these cardiac disorders.This treatise is an eminent successor to Hamilton and Thomsoin's study, at the Boston Lying-In-Hospital, of 8.50 pregnant womnen with heart disease published in 1941.The authors state that if disease during preg- nancy is to be well managed, the physiologic changes of pregnancy must first be known.Successive chapters deal with maternal adjustments to pregnancy, the organization of the cardiac clinic for proper management of their patients, the diagnostic criteria of heart disease in pregnancy, the prognosis of heart disease in pregnant women, and the details of the medical management of the pregnant patient with heart disease.The authors state, "With present-day medical management and close cooperation between the
Cholelithiasis in a Child with Sickle Cell Anemia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Breast
Authors: A. Ellis
Journal: BMJ (2003)

Directed by Paul Clayton East Midlands Conference Centre, Nottingham, 17 September 2003 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Four years ago I had a benign lump the size of a golf ball removed from my breast. That it was anything other than benign was very much a possibility in my mind, despite my youth. However, the experiences that Guardian journalist and breast cancer survivor Polly Toynbee portrays in her first play, Breast –previewed last week at the Nottingham Breast Cancer Meeting–seem like Mount Everest in comparison with my own. Two … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Drug Regulation
Authors: SEYMOUR JOTKOWITZ
Journal: Annals of Internal Medicine (1980)

Letters1 April 1980Drug RegulationSEYMOUR JOTKOWITZ, M.D.SEYMOUR JOTKOWITZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-569_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dorsen and Miller, in their paper "The Drug Regulation Process and the Challenge of Regulatory Reform" (1), advocate speedy passage of the Drug Regulation Reform Act of 1979. To the contrary, the House of Representatives has acted wisely in delaying passage, since this act poses a serious threat to the public health and welfare. Specifically, it allows the FDA the authority to restrict distribution of approved drugs without requiring their availability to all physicians and patients willing to cooperate in their continued evaluation. The potential for abuse and favoritism by either the drug company or the FDA...References1. DORSENMILLER NJ. The drug regulation process and the challenge of regulatory reform. Ann Intern Med. 1979;91:908-13. LinkGoogle Scholar2. FED R. 6 July 1979;44(131):40028. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1980Volume 92, Issue 4Page: 569-569KeywordsDrug abuseDrug distributionDrug regulationDrugsFood and Drug AdministrationPrevention, policy, and public health Issue Published: 1 April 1980 PDF downloadLoading ...
Erratum
Journal: Journal of Clinical Oncology (2017)

The final sentence of the seventh paragraph read "The Ki67 measurement was then included in the PEPI algorithm and used to evaluate benefit."Instead, it should have read "The Ki67 measurement was also included in the PEPI algorithm and used to evaluate prognosis after surgery."Also, the first sentence of the ninth paragraph read "Z1031B made the next logical leap, giving standard chemotherapy to patients with a high PEPI score."Instead, it should have read "Z1031B made the next logical leap, giving standard chemotherapy to patients in whom the two-to four-week biopsy showed a Ki67 value above 10%."Lastly, the second sentence of the ninth paragraph read "This made perfect sense, with anatomy and biology suggesting both the need for and likely benefit from chemotherapy."Instead, it should have read "This made perfect sense, as in their modeling studies these patients were almost never in the PEPI-0 group and therefore eligible to be spared chemotherapy."The online version has been corrected in departure from the print.
Les syndromes ménièriques
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Abstracts
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Links between cocaine and retroviral infection
Authors: S. H. Weiss
Journal: JAMA (1989)

In 1981, clinicians and epidemiologists recognized the occurrence of a new syndrome since termed acquired immunodeficiency syndrome (AIDS).<sup>1,2</sup>Since then, parenteral and sexual transmission of an agent were implicated.<sup>3,4</sup>The subsequent discovery of human immunodeficiency virus type 1 (HIV-1) as the cause of AIDS, and tests for its reliable detection, revealed epidemic spread of this infectious agent that was more extensive and initially more silent than most observers had guessed.<sup>5-7</sup> Intensive epidemiologic studies of homosexual men, hemophiliacs, and blood transfusion recipients have been numerous and revealing.<sup>4</sup>Analogous research efforts among drug abusers have been somewhat slower to bear fruit.<sup>8</sup>In part, this reflects the challenges faced by researchers in enlisting representative samples of drug abusers. Drug abusers are frequently suspicious of "the establishment" and researchers can be perceived as being part of that establishment. Trained interviewers and attention to confidentiality are integral components in obtaining
LECTURES ON INTRACRANIAL SURGERY.VII—BRAIN TUMOR AND ITS SURGICAL TREATMENT.
Authors: EMORY LANPHEAR
Journal: JAMA (1895)

Resuming description of cases of tumor of the brain and its envelopes, upon which I have operated, I next wish to relate the history of an <h3>Osteoma—Operation—Recovery.</h3> —W. L. W., of Fairport, N. Y., aged 28 years, I first saw in June, 1889. His family history was good and his health excellent until 1884, when he had syphilis. In June, 1887, he fell and injured the right side of his head, from which he was unconscious for several hours. Soon afterward he began to have headache with a tender spot just in front of the right parietal eminence; then there was a change in his disposition; he became irascible, shiftless and vulgar, began drinking heavily and taking morphin for the head pain. Some time during 1888 he had a "stroke of paralysis" after a hard debauch, the left hand and arm remaining paralyzed for some weeks; motion gradually returned under
Guidance Needed in Newborn Screening for Congenital Heart Defects
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal