tbuckley/cabot-search huggingface dataset:
THE MODE OF PRODUCTION OF THE SO-CALLED VESICULAR MURMUR OF RESPIRATION
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Water hardness and cardiovascular mortality. An idea that has served its purpose
Authors: D. I. Hammer
Journal: JAMA (1980)

FOR MORE than 20 years, investigators have studied water hardness and cardiovascular disease (CVD) mortality.<sup>1</sup>Despite studies from several countries having yielded conflicting results,<sup>2</sup>recommendations have been made urging caution about softening drinking water, as though there were a simple and constant linear relationship between water softness and CVD mortality.<sup>3</sup>This discussion should make it clear why a simple linear hypothesis explaining these findings, eg, water hardness, per se, protects against heart disease, is untenable and probably incorrect. <h3>Schroeder Reconsidered</h3> Numerous reviews have cited Schroeder's<sup>4</sup>findings regarding water hardness and heart disease mortality, but they have rarely mentioned the correlations of water hardness with several other mortality categories in this same article. Schroeder reported significant negative correlations of water hardness with CVD mortality, cancer mortality, cirrhosis of the liver, population density, and percent nonwhite population. Conversely, he reported significant positive correlations of water hardness with motor
Asthma in Children: A Correction
Journal: BMJ (1929)

Expenses while on Colonial Leave."S.W. T. L.," a medical offleer in the Coloniial Service, is home on leave.Can he de(iluct aniything iu resp §ct of expenises in- curr-ed (a) in the pur6habpand future freBight to the colony of a car whiehl is beiug use'd for pleasure buit wvill be taken abtroad for p)rofessionial use, aud (b) in couuexiou with a post-graduate conrse he is taking? . (a) Preseut expenses are not wholly, exclusively, and necessarily iucurred in tle performance of thie duties of his office anid caunot be deducted iu the taxation of bis leave pay.(b) No; such expense is analogous to capital outlay for a future return.Colonial Gratuities."J. C. D." asks if gratuities for services in military and colonial medical services are subject to iucome tax, whether the recipieut is a British resi(leut or not.G Gratuities paid iu respect of service In connexion with the Great War to members of the military forces of the Crown were specifically exenmpted by Sectiou 17 of the Fiuance Act, 1919.If our corresponident's gratuities do not fall within that description, we do not know of any grountds ou which they can be claimed to be outside the scope of the tax.Non-
Treatment of prolactinomas with megavoltage radiotherapy.
Authors: A Grossman, M Besser, J Wass, L Rees
Journal: BMJ (1984)

The outcome of treatment of 36 women with prolactinomas using megavoltage radiotherapy combined with interim dopamine agonists (bromocriptine, lysuride, pergolide) was reviewed; 16 of the women showed radiological evidence of a macroadenoma.The most common presenting symptom was secondary amenorrhoea; 26 of the patients had galactorrhoea.In 29 patients who wished to conceive the ovulation rate (as indicated by circulating progesterone concentrations) was 97% and the successful fertility rate 86%.No patient had enlarge- ment of the tumour during pregnancy and there were no complications of radiotherapy.No further tumour enlargement was detected in serial skull radiographs, and an improvement in size of the fossa was noted in 45% of those assessed.When medical treatment was withdrawn a mean of 4-2 years (range 1-11) after radiotherapy in the 27 patients who had completed their families the serum prolactin concentration had fallen appreciably in 26 of them and later became normal in eight.The incidence of growth hormone deficiency rose from 24% of the whole group before radiotherapy to 79% afterwards.Only one patient required thyroxine, and one was receiving gonado- trophin.No patient became deficient in adrenocortico- trophic hormone.A regimen of megavoltage radiotherapy and interim bromocriptine allows women with prolactinomas safely
Abstract 3777: Exploring phenotypic mosaicism in a mouse model of glioma towards understanding intratumoral heterogeneity
Authors: Toshiro Hara
Journal: Cancer Research (2019)

Abstract The lethality of glioblastoma multiforme (GBM) and the failure of treatment is largely attributable to the heterogeneous properties of this cancer. We aim specifically to characterize the driving event for GBMs to acquire a heterogeneous phenotype during progression. Central to achieving this goal is the ability to interrogate possible sources of heterogeneity that guide cellular states that are similar to those identified in human patients. We therefore employ a mouse model of glioma that recapitulates the pathophysiology and gene expression signatures of human GBM. While initiated with identical oncogenic drivers, this mouse model unexpectedly displays heterogeneous phenotypes between animals. Our preliminary data using time-series single-cell transcriptomics approach shows that transformed cells, even without acquiring additional genetic alterations, switch cellular states at the beginning of tumor formation and one population commit themselves to expand to establish gliomas that are mainly comprised of one cell type. We further observe the strong association of microenvironmental cues with glioma cell populations and their roles in the state transitioning of glioma cells. Through the characterization of mechanisms that drive phenotypic mosaicism, we hope to uncover general principles that govern tumor progression and heterogeneity, and then ultimately provide novel therapeutic strategies to cure GBM. Citation Format: Toshiro Hara. Exploring phenotypic mosaicism in a mouse model of glioma towards understanding intratumoral heterogeneity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3777.
Erratum: Non-replicating rhabdovirus-derived particles (NRRPs) eradicate acute leukemia by direct cytolysis and induction of antitumor immunity
Authors: C Batenchuk, F Le Boeuf, L Stubbert, T Falls, H L Atkins, J C Bell, D P Conrad
Journal: Blood Cancer Journal (2014)

Correction to: Blood Cancer Journal (2013) 3, e123; doi: 10.1038/bcj.2013.23; published online 12 July 2013 Since the publication of this article, it has come to the authors attention that there are two small syntax errors in the mathematical equations (on page 2) and also within the supplementary table.
Directors at New York Eye and Ear Infirmary
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Author Name
Authors: Marie Baeck, Anne Herman
Journal: JAMA Dermatology (2021)

Rosalynn R. Z. Conic, MD, PhD; Gabriella Fabbrocini, MD; Claudio Marasca, MD; Nicola L. Bragazzi, MD, PhD; Abdulla Watad, MD; Mohammad Adawi, MD; Giovanni Damiani, MD
BOOK REVIEWS
Authors: S. A. GROSSMAN
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article BOOK REVIEWS Get access The Management of Pain, Volumes I and II John J. Bonica , ed (with collaboration of John D. Loeser , C. Richard Chapman , Wilbert E. Fordyce ). Philadelphia : Lea & Febiger , 1990 , vol I - 958 pp, vol II - 1150 pp. $225. STUART A. GROSSMAN STUART A. GROSSMAN The Johns Hopkins Oncology Center600 N Wolfe St Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 21, 7 November 1990, Pages 1717–1718, https://doi.org/10.1093/jnci/82.21.1717-a Published: 07 November 1990
Blood flow in the skin of the foot related to posture in diabetes mellitus
Authors: G Rayman, A A K Hassan, J E Tooke
Journal: BMJ (1986)

Normal healthy subjects show a reflex rise in precapillary resistance in the skin of the foot when they rise from lying to standing.To investigate the integrity ofthis reflex in patients with diabetes mellitus blood flow in the plantar region of the big toe was measured, using a laser Doppler flowmeter.The responses of diabetic patients with and without peripheral sensory neuropathy and healthy control subjects matched for age and sex were studied, with the foot at heart level and the foot passively lowered to 50 cm below the heart.In normal subjects mean blood flow recorded during the third to fourth minute of dependency fell to 18-1 (SD 11-9)% of the preceding resting flow determined with the foot at heart level.In the diabetic patients without neuropathy blood flow fell to 28.9 (18-6)% ofthe preceding resting flow.In the diabetic patients with neuropathy blood flow fell to 53-5 (23-7)% of the preceding resting flow, which was significantly different from the value achieved by the diabetics without neuropathy (p<0-02) and the healthy controls (p<0002).Six normal subjects were indirectly heated to release sympathetic tone and achieve the same mean skin temperature of the foot as the diabetic patients with neuropathy, and blood flow fell to 38-7 (24-3)% of the preceding resting flow, a value not significantly different from the response seen in the patients with neuropathy.These findings suggest that the postural control of blood flow in the foot is disturbed in patients with diabetic neuropathy, and this disturbance is compatible with a loss of sympathetic vascular tone.The resultant hyperperfusion on dependency may account for the oedema seen in some patients with neuropathy and may also act as a stimulus for the thickening of capillary basement membranes.
Orthopedics
Authors: Bernard F. Morrey
Journal: JAMA (1991)

Recent clinical and basic research activity in orthopedics covers a broad spectrum of clinical topics. This article reviews the progress in implant fixation, spine surgery, and, possibly most significant, the application of molecular biology to the practice of orthopedic surgery. Emerging concerns relating to prosthetic replacement include issues of implant survival, fixation, wear, and debris formation. The first large series of patients in the United States with the original Charnley hip replacement have been followed up for 15 years, as presented by Kavanagh et al<sup>1</sup>from the Mayo Clinic. The long-term results were surprisingly good, as this analysis revealed that 78% of the implants were satisfactory (good or excellent) 15 or more years after implantation; 88% were still functioning. These data serve as an important benchmark against which future clinical studies may be compared. In addition, the limited autopsy results from individuals who have had long-term, well-functioning implant devices do
Erratum
Journal: Journal of Clinical Oncology (2018)

In Figure 1, the 6 th box from the top on the left reads: Futility analysis: If fewer than four of 20 patients with response, continue recruitment to at least 53 patients Responses in the first 20 patients (n 5 8) Recruitment Continued This should have read: Futility analysis: If fewer than four of 20 patients with response in arm A, stop recruitment, otherwise continue until at least 53 evaluable patients Responses in the first 20 patients (n 5 8) Recruitment Continued In Figure 1, the 6 th box from the top on the right reads: Futility analysis: If fewer than three of 30 patients with response, continue recruitment to at least 64 patients Responses in the first 30 patients (n 5 2) Recruitment was closed This should have read: Futility analysis: If fewer than three of 30 patients with response, stop recruitment, otherwise continue until at least 64 evaluable patients Responses in the first 30 patients (n 5 2) Recruitment was closed This has been corrected as of October 18, 2018.The authors apologize for the errors.
Urban violence in Los Angeles in the aftermath of the riots. A perspective from health care professionals, with implications for social reconstruction
Authors: W. C. Shoemaker
Journal: JAMA (1993)

Beginning April 29, 1992, Los Angeles, Calif, was engulfed in a 3-day insurrection reflecting the residents' responses to a legal ruling. Unlike the media-painted picture, this article argues that the enormous outburst of violence and consequential property destruction was not the exclusive domain of the citizens of South-Central Los Angeles and that available data will not support the maintenance of the prevailing uneven distribution of civic and state resources in health care, educational programs, and economic opportunities. What it does support is the proposal for a more equitable allocation of resources among institutions, groups, and peoples, complemented by community empowerment, a more civic-oriented police operation, and a more rational approach to social reconstruction in which all elements of the society are full participants. Finally, the article suggests that augmentation of the present "law and order" approach and the paramilitary police already have proven economically ineffective. Given the dominant role of the medical profession in social and civic life, it is now appropriate for the medical profession to enter the debate on policies of health improvement, violence deterrence, and the general field of social reconstruction. (<i>JAMA</i>. 1993;270:2833-2837)
Secrecy in Science: The Flock Worker's Lung Investigation
Authors: Miriam Shuchman
Journal: Annals of Internal Medicine (1999)

Letters6 April 1999Secrecy in Science: The Flock Worker's Lung InvestigationMiriam Shuchman, MDMiriam Shuchman, MDState University of New York, Buffalo; Buffalo, NY 14215 (Shuchman)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-7-199904060-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Annals asked me to provide an in-depth exploration of the story about Dr. Kern. That sort of journalistic investigation strives for objectivity. For the record, I agree that what happened to Dr. Kern was ugly. First, a private company attempted to prevent him from presenting at a scientific meeting. Then, his hospital and university failed to support his right to present, and they subsequently dismissed Dr. Kern from his job. In my view, those institutions should have supported Dr. Kern in his fight for academic freedom and open scientific discourse. I've said as much in an opinion column ...Reference1. Blame it on the universities. Globe and Mail. 29 December 1998:C7. Google Scholar Author, Article, and Disclosure InformationAffiliations: State University of New York, Buffalo; Buffalo, NY 14215 (Shuchman) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFlock Worker's Lung: Chronic Interstitial Lung Disease in the Nylon Flocking Industry David G. Kern , Robert S. Crausman , Kate T.H. Durand , Ali Nayer , and Charles Kuhn III Metrics 6 April 1999Volume 130, Issue 7Page: 616KeywordsLungs Issue Published: 6 April 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
In the Spotlight: Biomedical Imaging
Authors: A.F. Laine
Journal: IEEE Reviews in Biomedical Engineering (2009)

This article resumes on a selected set of topics and collects promising and recent research advances in the field of multimodal temporal data analysis, high-field magnetic resonance spectroscopy, trends in computer-aided diagnosis and advances in cardiac diagnostic imaging. The first section briefly points to promising work on statistical models for tracking, detection, and segmentation in multimodal temporal imagery. Section III gives a brief snapshot of slice selective free induction decay (FID) acquisition for 7 tesla high-field MR imaging. Section IV outlines highlights in comparative validation of computer-aided diagnosis and associated image analysis algorithms spanning a variety of application domains from the heart to the eye. Lastly, Section V describes advances in the analysis of real-time three-dimensional (3-D) echocardiography for computing myocardial strain.
A realistic journal reading plan. The cornerstone of continuing medical education
Authors: W. E. Scheckler
Journal: JAMA (1982)

THE ARRAY of ways for a physician to keep current with the changes and increases in knowledge is large and growing. Conferences in the hospital, in the region, in the country, and in the world are provided. Audiotapes, videotapes, self-learning modules, and home study courses abound. Refereed journals and newsletters plus a burgeoning number of nonsubscription "throwaway" periodicals also vie for the limited time of the busy physician. The broad scope of family medicine is a particularly intriguing challenge. This article presents a suggested guide for residents and practicing physicians to establish a sound core of continuing medical education. Although some articles have addressed the issues of continuing education,<sup>1-3</sup>many state licensing boards require continuing medical education (CME) credits for relicensure, and the American Academy of Family Physicians specifies a number of hours of "prescribed" and "elective" credits for continuing membership, little is known of the impact of CME on
Abstract 27: Loss of GATA4 in Kit Lineage-derived Endothelium Leads to Vascular Permeability and Increased Heterotypic Fusion
Authors: Bryan D Maliken, Onur Kanisicak, Jason Karch, Jeffery D Molkentin
Journal: Circulation Research (2017)

The treatment of cardiac ischemic injury using heart-derived c-Kit stem cells showed promising results in clinical trials with scar reduction and improved ejection fraction following coronary infusion. We previously developed a c-Kit lineage tracing mouse model showing that these cells very rarely convert into de novo cardiomyocytes and most lineage-derived cardiomyocytes are due to fusion. To potentially reduce this de novo rate to zero, and unequivocally evaluate the cellular fusion process in vivo , we deleted the essential cardiomyogenic transcription factor Gata4 in c-Kit cells using a Cre-loxP approach (Kit-Gata4 KO). Mice with the tamoxifen inducible Kit-MerCreMer allele crossed into a Gata4 homozygous LoxP targeted background with the Rosa26-eGFP reporter were fed tamoxifen at weaning to delete Gata4 in all c-Kit expressing cells and show them and their progeny as eGFP + . Unexpectedly, we observed a greater than 10-fold increase in Kit lineage-traced cardiomyocytes in Kit-Gata4 KO mice compared to Kit only controls with up to 4 months of tamoxifen treatment (90% v. 81% fusion in Kit-Gata4 KO v. controls). A 6-fold increase in leukocyte (CD45 + ) infiltration was observed suggesting the possibility for greater rates of fusion in the heart. However, bone marrow transplant studies revealed that Kit-Gata4 KO bone marrow does not exhibit increased cardiac infiltration or heterotypic fusion with cardiomyocytes. The reciprocal experiment, donating control bone marrow to recipient mice with Kit-Gata4 KO hearts, showed a 4-fold increase in fusion of control bone marrow showing that increases in fusion was intrinsic to the cells within the heart. Analysis of cardiac endothelial cells in Kit-Gata4 KO mice revealed that total CD31 + cells were increased by 30% with 2 months of tamoxifen treatment with a parallel increase in endothelial progenitor cells (CD133 + ) in the bone marrow. This endothelial phenotype was corroborated using endothelial-specific deletion of Gata4 in a Tie2-CreER mouse which showed a 5-fold increase in both CD31 + cells and vascular permeability after 1 month of tamoxifen. Currently, studies are underway to assess the mechanism of altered endothelial integrity and expansion in the absence of Gata4 in c-kit hemoangioblast progenitors.
Functional trajectories before and after a new cancer diagnosis among community-living older adults.
Authors: Carolyn Jean Presley, Arti Hurria, Ling Han, Linda S Leo-Summers, Cary Philip Gross, Heather G Allore, Amy J. Davidoff, Thomas M Gill
Journal: Journal of Clinical Oncology (2017)

e21547 Background: We characterized distinct functional trajectories among older adults in the year before and after a new cancer diagnosis and identified factors associated with functional decline. Methods: Among a cohort study of persons 70+ y, we identified 170 participants (lung (15.7%), breast (12.4%), prostate (7.8%); 31.8% incurable at diagnosis)) with an incident cancer diagnosis from 1998-2014. We followed their functional course using 13 basic, instrumental, and mobility activities measured during monthly interviews. To identify functional trajectories, we fit a group-based trajectory model of the 13-item disability scale 12-months before and 12-months after the cancer diagnosis. Regression modeling determined predictors of functional decline, defined as a higher count on the 13-item disability scale. Results: Three pre-cancer functional trajectories were identified (mean age at diagnosis: 83 y (73-105 y); similarly, 3 post-cancer functional trajectories were identified among the 158 non-decedents. Participants with severe disability pre-diagnosis remained severely disabled post-diagnosis. Approximately 40% of participants with mild or moderate disability pre-diagnosis transitioned to a worse functional trajectory post-diagnosis (see Table). Moderate and severe disability pre-diagnosis were significantly associated with functional decline post-diagnosis (moderate vs. mild aRR: 3.10; 95% CI: 2.24-4.30; severe vs. mild aRR: 5.71; 95% CI: 3.60-9.07). Depressive symptoms (RR, 1.40; 95% CI: 1.02-1.91), and incurable stage (RR, 2.16; 95% CI: 1.54-3.03) were also associated with functional decline. Conclusions: Approximately 40% of older adults experienced functional decline after a new cancer diagnosis. Pre-cancer diagnosis functional trajectory, depressive symptoms, and incurable stage were significant predictors of post-diagnosis functional decline. [Table: see text]