tbuckley/cabot-search huggingface dataset:
THE DIGESTION OF SUGAR
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dialume-Diabinese disaster
Authors: F. L. Arlow
Journal: JAMA (1983)

<h3>In Reply.—</h3> I concur with Dr Garbitelli's assessment of the limited political involvement by physicians in recent years. In particular, there seems to be little incentive for a physician to transfer from the medical field, which is generally held in high public regard, to political office, which is often publicly viewed with scorn and derision. This is unfortunate, because if the high ethical standards and conduct that are practiced every day in the hospital were applied to politics, serving in public office would possibly attain the respect it deserves.
Esophageal Carcinoma
Authors: Anil K. Rustgi, Hashem B. El-Serag
Journal: New England Journal of Medicine (2014)

The 5-year survival rate in esophageal cancer, although poor, has improved over the past decade. This review discusses the epidemiologic aspects, pathogenesis, prevention, and therapy of esophageal adenocarcinoma and squamous-cell carcinoma, focusing on recent advances.
Medical News
Journal: JAMA (1930)

(Physicians will confer a favor by sending for this department items of news of more or less general interest: such as relate to society activities, new hospitals, education, public health, etc.) <h3>COLORADO</h3><h3>Society News.</h3> —The Larimer County Medical Society was addressed, October 1, by Dr. James A. Matlack, Longmont, on "Publicity for the Physician," and by Dr. Magnus J. Stewart, Loveland, on "Aviation Eye Tests."—The Medical Society of the City and County of Denver was addressed, October 21, by Dr. Earl J. Perkins, Denver, on "Difficulties in Varicose Vein Injections."—Dr. Alfred H. Washburn has assumed the position of full-time director of the child research council of the University of Colorado School of Medicine and Hospitals. <h3>CONNECTICUT</h3><h3>Society News.</h3> —The New Haven County Medical Society held its one hundred and forty-seventh semiannual meeting at Waterbury, October 23. Addresses were given by Drs. William H. Morriss, Wallingford, on "Value of Blood Cell
Clinical, histological, and biochemical liver phenotype of European adults with heterozygous alpha-1 antitrypsin deficiency (Pi*MZ genotype)
Authors: Karim Hamesch, Carolin Victoria Heimes, Annika Gross, Mattias Mandorfer, Linda S. Moeller, Vítor Pereira, Monica Pons Delgado, Pawel Kuca, Matthias C. Reichert, Federica Benini, Georg Lurje, Joan Genesca, Frank Lammert, Aleksander Krag, Michael Trauner, Alexander Teumer, Nadine Gaisa, Helmut Denk, Christian Trautwein, Elmar Aigner, Pavel Strnad
Journal: Journal of Hepatology (2020)
Notes From the Field: Carbon Monoxide Exposures Reported to Poison Centers and Related to Hurricane Sandy—Northeastern United States, 2012
Journal: JAMA (2012)

Hurricane Sandy made landfall as a post-tropical cyclone along the coast of southern New Jersey on Monday, October 29, 2012. In the wake of Sandy, state and federal public health agencies have observed an increase in the number of exposures to carbon monoxide (CO) reported to poison centers. CO is imperceptible and can cause adverse health effects ranging from fatigue and headache to cardiorespiratory failure, coma, and death. CO poisoning is a leading cause of mortality and morbidity in post-disaster situations, when widespread power outages occur and risky behaviors, such as improper placement of generators and indoor use of charcoal grills, increase.
Treatment of basal cell epitheliomas and actinic keratoses
Authors: G. T. Jansen
Journal: JAMA (1976)

BASAL cell epithelioma is the most common skin carcinoma in the United States. Because these lesions rarely metastasize, their medical importance has been minimized by some, and others have approached treatment with a cavalier attitude. Fortunately, a majority of basal cell epitheliomas can be cured with a simple treatment approach, especially when the lesions are of the common "rodent ulcer" or<i>solid</i>type (Fig 1), containing only a small amount of fibrous stroma. However, the physician must realize that this carcinoma has an unusual number of clinical traits capable of invading cartilage and bone and extending along blood vessels and nerves, leading toward the recurrent, serious, and complicated cases (Fig'2). These variations include the<i>superficial erythematous</i>type (Fig 3), which may resemble psoriasis or eczema. Treatment may be delayed because of clinical misinterpretation. Another form may be<i>deeply pigmented</i>(Fig 4) and mistaken for a nevus, or malignant melanoma. The
Conference on indications for tonsillectomy and adenoidectomy
Authors: J. L. Paradise
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Our recent article inThe Journal(240:1255, 1978) on current advances in the development of less hazardous cigarettes resulted in scores of letters to us from physicians, scientists, and other concerned citizens. Two such letters, addressing the extremely important issues of the inhalation practices of smokers and of additives used in the manufacture of commercial brand cigarettes, are to be published inThe Journal, with our comments. We would like to take the opportunity here to clarify additional issues that were raised during the ensuing mass media coverage of our findings. It should be emphasized at the outset, however, that our article was intended to be evaluated on its merits by the readers ofThe Journaland was not intended for general mass media distribution. It was stated in the lay press that our analyses were statistical manipulations of data from short-term animal studies. However, neither animal
CEREBRAL EMBOLISM FOLLOWING THE ARREST OF AURICULAR FIBRILLATION BY QUINIDIN
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Queries and Minor Notes
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utility of HBsAg quantification in developing an individualised approach to the management of chronic hepatitis B virus in clinical practice
Authors: A. Gunawan, U. S. Gill, F. Glyn, P. Kooner, R. Marley, I. Ushiro-Lumb, G. R. Foster, P. T. F. Kennedy
Journal: Gut (2011)

<h3>Introduction</h3> HBsAg is a surrogate marker of cccDNA, its loss is associated with sustained immune control and reduction in the development of HCC. HBsAg quantification (qHBsAg) has facilitated the on-treatment monitoring of response to pegylated interferon α (IFNα) with the potential to individualise therapy according to response. HBsAg decline with oral antivirals (OAV) is reported to be a slower process; however any reduction in HBsAg could potentially be used as a tool to determine duration of therapy, in lieu of recommended lifelong treatment. This study examined the utility of HBsAg quantification in developing individualised treatment strategies for both IFNα and OAV treated patients. <h3>Methods</h3> 86 CHB patients (male=72) were included for analysis. All patients underwent qHBsAg (ABBOTT Architect) in addition to longitudinal measurement of ALT and HBV DNA. 60 patients (male=54), median age 45 (range 21–70), were treated with combination Tenofovir and Lamivudine; qHBsAg was recorded at baseline, 12 and 24 months. 26 patients (male=18), median age 31 (range 18–55), were treated with IFNα. HBsAg was quantified at baseline, 12 and 24 weeks. HBsAg decline was compared in the OAV and IFNα groups at 12 and 24 months versus 12 and 24 weeks respectively. <h3>Results</h3> In the OAV group, baseline median ALT 42.5 (range 15–181) and median HBV DNA 3.43 log (range 1.5–7.9). At 12 months, ALT normalisation was achieved in 60% and undetectable DNA in 90%. Mean HBsAg decline in this group was 0.06 log at 12 months. ALT normalisation and viral suppression was sustained at 24 months. HBsAg decline, however, was not sustained and there was an overall mean increase of 0.1 log from baseline. In the IFNα group, baseline median ALT 113.6 (range 29–448) and median HBV DNA 7.21 log (range 3.58–9.25). HBsAg decline was measured 12 weekly. 8/26 (31%) patients had a &gt;0.5 log decline at 12 weeks and this increased to 45% at 24 weeks. HBsAg decline was significantly greater in the IFNα group when compared with the OAV group at 12 weeks versus 12 months and more marked at 24 weeks versus 24 months (p=0.03 and p=0.006 respectively). <h3>Conclusion</h3> These data highlight the utility of qHBsAg in IFNα therapy and raises the possibility of an individualised, response guided approach allowing early changes in treatment regimen if indicated. Consistent with published data, the 24-week HBsAg is a better predictor of sustained immune control. Conversely, there was a limited HBsAg decline in OAV treated patients over prolonged follow-up and this reduction was not sustained. This suggests that HBsAg quantification alone cannot be used to individualise therapy and determine treatment duration with OAV9s.
Hemangioma of the Liver
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fritz Spiegl's MuSick Notes--a Medical Song Book
Journal: Journal of the Royal Society of Medicine (2003)

Oxygen: the Molecule that made the WorldThe word 'enthusiast' has changed in meaning over the years.In the eighteenth century, it was not wholly complimentary: 'One who vainly imagines a private revelation; one of a hot imagination or violent passions; one of elevated fancy or exalted ideas' wrote Dr Johnson in his Dictionary of 1755.Addison noted with distaste that certain religious sects displayed 'strong Tinctures of Enthusiasm'.Nick Lane is clearly an enthusiast in a modern, non-pejorative sense.What other description can you apply to an author who sets out to write about '. . .life, death and oxygen: about how and why life produced and adapted to oxygen; about the evolutionary past and future of life on Earth; about energy and health, disease and death, sex and regeneration; and about ourselves' (p.2)?All this in a book 1 that is '. . .not a catalogue of dry facts . . .rather, like science itself, it is full of quirks, experiments, oddities, speculations, hypotheses and predictions' (pp.[13][14].These two quotations are useful in that they at once indicate the ambitious scale of the book and some of the difficulties the reader may encounter.Paraphrasing and grossly reducing Lane's own aims, we may say that he pursues three huge topics-the formation of an oxygenated atmosphere, the emergence of oxygendependent organisms, and the complementary hazards of oxygen toxicity.About one-third of the way through the book, chapter five, readers may be disconcerted to find themselves no further than the carboniferous period; but by chapter fifteen they will have found extended discussions of the biochemical, biological and pathological aspects of free radicals.Much emphasis is given to ageing and to agerelated diseases.Lane necessarily draws on information from a wide range of disciplines: a list including geology, geochemistry, palaeontology, biochemistry, zoology, genetics, molecular biology and medicine is representative but by no means complete.In any one of them, experimentally described data will (self-evidently) vary enormously in terms of the methodologies by which they are derived and the extent to which they can be validated and legitimately extrapolated.Certain findings, sometimes obtained from restricted and highly contrived conditions, may prove to be compatible with other observations and come to form an evidential basis for plausible, testable theories.Cumulative weight of evidence is a familiar notion; but so, too, is the recognition of anomalies which (though securely based) do not fit into accepted schemata and may indeed eventually lead to their modification or rejection.This state of permanently
Nervous Indigestion.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis
Authors: Yuntao S. Mao, Masaki Yamaga, Xiaohui Zhu, Yongjie Wei, Hui-Qiao Sun, Jing Wang, Mia Yun, Yanfeng Wang, Gilbert Di Paolo, Michael Bennett, Ira Mellman, Charles S. Abrams, Pietro De Camilli, Christopher Y. Lu, Helen L. Yin
Journal: The Journal of Experimental Medicine (2009)
Nipple Priapism
Authors: William P. Graham
Journal: JAMA (1987)

<h3>To the Editor.—</h3> In QUESTIONS AND ANSWERS in the June 26 issue of<i>JAMA</i>,<sup>1</sup>the inquiry regarding nipple priapism merits comment. This condition is not that uncommon following reduction mammoplasty. Nipple priapism is often corrected by a four-quadrant wedge resection of the nipple area, reducing the nipple in size and height. This seldom disturbs sensation and, in my experience, has relieved or considerably diminished the symptoms in all patients affected. When the condition occurs in men (which is far rarer but more often associated with administration of antihypertensive medications), it is most readily managed by subareolar denervation of the nipple through a small circumareolar incision.
Highlights
Authors: Fan Liao, David Holtzman
Journal: JAMA Neurology (2014)

Liu and colleagues analyze purified neurons derived from human induced pluripotent stem cells from patients carrying 3 different presenilin 1 mutations and nondemented control individuals in the absence of any overexpression.Adult human skin biopsies were obtained from volunteers at the Alzheimer Disease Research Center, University of California, San Diego.The results suggest that biomarker signatures obtained with such models are misleading and that human neurons derived from human induced pluripotent stem cells provide a unique signature that will more accurately reflect drug response in human patients and in cerebrospinal fluid biomarker changes observed during γ-secretase modulator treatment.
Personal View
Authors: D. Black, E. Guthrie
Journal: BMJ (1990)

<b>1199</b> <h3><b>Introduction:</b></h3> Radiotracer [<sup>18</sup>F]Flortaucipir is an FDA-approved diagnostic agent for PET imaging of abnormal tau protein deposition in Alzheimer’s disease. A high-yield automated method for routine GMP-compliant [<sup>18</sup>F]Flortaucipir production is desired to meet increasing clinical need. In this study, we reported the automated radiosynthesis of [<sup>18</sup>F]Flortaucipir in RNplus Research module and the quality control testing under fully compliant cGMP environment. <h3><b>Methods:</b></h3> Automated production of [<sup>18</sup>F]Flortaucipir was processed via nucleophilic radio-fluorination of precursor AV1622 and followed by acid hydrolysis in a RNplus Research module, which included the radiotracer radiosynthesis, semi-preparative high-performance liquid chromatography (HPLC) purification, and the final formulation via solid phase extraction (SPE). Briefly, [<sup>18</sup>F]Fluoride trapped on an QMA cartridge was eluted off with K<sub>2.2.2</sub>/K<sub>2</sub>CO<sub>3</sub> solution, and followed by azeotropic drying. AV1622 (1 mg) in DMSO (1 mL) was reacted with dried [<sup>18</sup>F]Fluoride at 110 °C for 5 minutes, and de-protected with 3 N HCl (aq) at 100 °C for 5 minutes. The mixture was neutralized with 0.5 N NaOH (aq), and pre-purified by an Oasis HLB cartridge with water, and then eluted off using 1.5 mL of acetonitrile. The crude [<sup>18</sup>F]Flortaucipir was diluted with 1.5 mL of water and loaded onto a semi-preparative C18 HPLC column for purification at a flow rate of 4 mL/minute. The collected product fraction was diluted with 30 mL water, trapped on a tC18 Cartridge, washed with 10 mL sterile water, and then eluted off with 1.2 mL ethanol and formulated with 10 mL 0.9% sodium chloride. The quality control (QC) tests of [<sup>18</sup>F]Flortaucipir, including appearance, pH, half-life, radiochemical purity and identity, chemical impurities, residual solvents content, residual K<sub>2.2.2 </sub>concentration, molecular activity, radioactive concentration, filter integrity, endotoxin and sterility, were conducted at end of synthesis (EOS) and 8 h after EOS during the production validation runs. <h3><b>Results:</b></h3> Three consecutive batches of [<sup>18</sup>F]Flortaucipir production were successfully completed within defined specifications. The uncorrected radiochemical yields of [<sup>18</sup>F]Flortaucipir were 14.8 - 16.6% with a total synthesis time of ~55 min. The radiochemical purities of [<sup>18</sup>F]Flortaucipir were &gt;99.9% and the molar activities were 6.7 - 10.4 Ci/µmole at EOS. The full QC results at EOS and 8h showed that the produced [<sup>18</sup>F]Flortaucipir met all the release criteria for clinical use within 8 hours of expiration time. <h3><b>Conclusions:</b></h3> [<sup>18</sup>F]Flortaucipir was reproducibly achieved with desired radiochemical yield and high radiochemical purity and molar activity under cGMP compliance. Three production validation runs and QC results demonstrated the efficacy of method for clinical use.