tbuckley/cabot-search huggingface dataset:
Hematologic data on healthy very old people
Authors: Edzard Ernst, Arpad Matrai
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Zauber and Zauber<sup>1</sup>conclude from their investigation of old, apparently healthy people that hematologic data are essentially unaffected by age. However, the population studied was small, several inclusion criteria seem somewhat vague, and significant differences were seen between old and young men, mainly in regard to hemoglobin-dependent variables. There thus seems to be a contradiction between their data and their conclusion. <h3>Study.—</h3> In an epidemiologic study,<sup>2</sup>we recently tested a random sample of the population (n = 4022). Using strict criteria (no signs of chronic disease; no smoking; no medications; blood pressure &lt;160/95 mm Hg; cholesterol level &lt;6.70 mmol/L [260 mg/dL]; urea level &lt;400 mmol/L [1120 mg/dL] in men and &lt;340 mmol/L [952 mg/dL] in women; body mass index &lt;30 kg/m<sup>2</sup>; and a normal resting electrocardiogram), 567 persons were defined as healthy. Among other factors, we measured hemoglobin level and plasma viscosity. These data are
Customer Exposure to MTBE, TAME, C 6 Alkyl Methyl Ethers, and Benzene during Gasoline Refueling
Authors: Sinikka Vainiotalo, Yrjo Peltonen, Anne Ruonakangas, Pirkko Pfaffli
Journal: Environmental Health Perspectives (1999)

We studied customer exposure durinug refuling by coliecdng air samples from customers' breath- ing zone.The meaurements wer carried out during 4 days in summer 1996 at two Finnish sdf- service gasoline stations with "stage I" vapor recovery systems.The 95-RON (research octane number) gasoline contained -2.7% methyl ~mbuty ether (MTBE), -85% eramyl methyl ether (TAME), -3.2% C6 alkyl methyl ethers (C6 AMEs), and 0.75% benzene.The individual exposure concentrations showed a wide log-normal distribution, with low eposures being the most frequent.In over 90% of the samples, the concentrtion of MTBE was higher (range <0.02-51 mg/m3) than that of TAME The MTBE vlues were well below the short-term (15 min) tehold limits set for ocupational exposure (250-360 mg/m3).At station A, the geometric mean concentrains in individual samples were 3.9 mg/m3 MTBE and 2.2 mg/m3 TAME.The corsponding values at station B were 2.4 and 1.7 mg/m3, respecly.The average refueling (sampling) time was 63 sec at station A and 74 sec at sation B. No statisticaily significant differ- ence was observed in customer eTosures bewen the two service stations.The overall geometrc means (n = 167) for an adjusted 1-min refueling time were 3.3 mg/im3 MTBE and 1.9 mg/m3 TAME.Each day an ntegrate d breathing zone sample was also collected, corresponding to an arithmetic mean of20-21 r lings.The overall arithmetic mean concentrtions in the integrat- ed samples (n -8) were 0.90 mg/mn3 for benzene and 0.56 mg/m3 for C6 AMEs calculated as a group.Mean MTBE concentrations in ambient air (a stationary point in the middle of the pump island) were 0.16 mg/m3 for station A and 0.07 mg/m3 for station B. The mean ambient concen- trations ofTAME, C6 AMEs, and benzene were 0.031 mg/m3, -0.005 mg/nm3, and -0.01 mg/m3, respctiey, at both stations.The mean wind speed was 1.4 m/sec and mean air temperature was
PULMONARY HEMOSIDEROSIS
Authors: J C Potier
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Title Change
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pharmacokinetics of intraperitoneal docetaxel and S-1 in patients with gastric cancer with peritoneal carcinomatosis
Authors: K. Hayashi, H. Kamikozuru
Journal: Journal of Clinical Oncology (2009)

e15672 Background: One of the most causes of death from gastric cancer is peritoneal cartinomatosis. Intraperitoneal docetaxel infusion is expected to be a new strategy for a treatment of peritoneal carcinomatosis. The purpose of this study is to evaluate the plasma and peritoneal pharmacokinetic of intraperitoneal docetaxel infusion in combination with oral administration of S-1. Methods: Eight patients with peritoneal carcinomatosis of advanced gastric cancer were enrolled. Docetaxel was dissolved in an isotonic saline to a final 1 liter solution and administered in 2 hour via an implanted intraperitoneal catheter at dosage of 40mg/m2. Five of eight patients were administered S-1 orally at dosage of 80mg/m2. Blood and peritoneal fluid were collected before administration, on completion of the docetaxel infusion(hour 0) and at hours 1,2,4,6,12,24,48,and 72 after completion of the infusion of the docetaxel. Plasma and peritoneal fluid concentrations of docetaxel and 5FU were evaluated. Results: The mean peak peritoneal and plasma concentrations of docetaxel were 18.6×103 ng/ml (at hour 0) and 45 ng/ml (at hour 0 to 2), respectively. The peritoneal concentrations of docetaxel were remained even after 24 and 72 hours (24 hours: 1150ng/ml, 72 hours: 74ng/ml). In seven out of eight patients, plasma concentrations of docetaxel were disappeared after 24 hours, but in only one patient with severe ascites, concentration of plasma docetaxel at hour 24 could be obtained (20 ng/ml). The mean peritoneal and plasma areas under the curves (AUC) of doceta×el were 141x103 ng/ml×hr and 480 ng/ml×hr, respectively. The mean peritoneal concentrations of 5FU kept over 60% of plasma concentrations (plasma: 164.3ng/ml, peritoneal: 105ng/ml). Conclusions: Intaperitoneal docetaxel kept relatively high concentrations even after 72hours. 5FU concentrations were well transfered in peritoneal fluid from plasma via oral S-1 administration. Intraperitoneal docetaxel in combination with S-1 orally may be a useful regimen to the patients with carcinomatosis of advanced gastric cancer. No significant financial relationships to disclose.
Season, Nutrition and Pellagra
Authors: Frederick Sargent, Virginia W. Sargent
Journal: New England Journal of Medicine (1950)

Other reports from Southern nutritional research groups independently confirm these trends in intakes of components of the vitamin B complex and suggest that the population receives the best nourishment just before clinical symptoms of malnutrition appear. Darby et al.,27 working in the same Tennessee community as Steinkamp and her associates,17 found that the urinary excretion of thiamine by pregnant women on the average was higher in the late winter and early spring (the seasons here have the usual designation) months, corresponding to the season of high pork and dried legume intake.‡ Although these two studies reveal that in the late . . .
Erratum for the Research Article: “Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy” by L. Amoasii, C. Long, H. Li, A. A. Mireault, J. M. Shelton, E. Sanchez-Ortiz, J. R. McAnally, S. Bhattacharyya, F. Schmidt, D. Grimm, S. D. Hauschka, R. Bassel-Duby, E. N. Olson
Journal: Science Translational Medicine (2018)
Annual Meeting of the Society for Clinical Trials
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Annual Meeting of the Society for Clinical Trials Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 5, November 1984, Page 1244, https://doi.org/10.1093/jnci/73.5.1244-a Published: 01 November 1984
Editorial Board
Authors: Donald Leung, Colo Deputy, Harold Nelson, Stanley Szefler, Colo Associate, Andrea Apter, Bruce Philadelphia, Baltimore Bochner, Joshua Boyce, Robert Bush, Fred Finkelman, Cincinnati Ohio, Qutayba Hamid, David Peden, William Shearer, Scott Sicherer, New York, Donata Vercelli, Ariz Guest, Burton Zweiman, Marc Rothenberg, Cincinatti Ohio
Journal: Journal of Allergy and Clinical Immunology (2006)
Who needs counseling in child abuse?
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aminoaciduria
Authors: Mary L. Efron
Journal: New England Journal of Medicine (1965)

DURING the past decade many different diseases, both hereditary and acquired, have been found to be associated with aminoaciduria. Not all aminoaciduria, however, is pathologic. Normal urine contains small amounts of many amino acids, and occasionally an otherwise normal person is found to have an excretion of glycine that is considerably greater than the average.Many amino acids are increased in concentration in urine in the first two or three months of life, presumably because the renal tubular absorptive mechanisms are not fully developed at birth. Aminoaciduria is therefore particularly difficult to evaluate in the newborn period; sometimes it is . . .
Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells
Authors: János Peti-Peterdi, Peter Komlosi, Amanda L. Fuson, Youfei Guan, André Schneider, Zhonghua Qi, Reyadh Redha, Laszlo Rosivall, Matthew D. Breyer, P. Darwin Bell
Journal: Journal of Clinical Investigation (2003)

Macula densa (MD) cells express COX-2 and COX-2-derived PGs appear to signal the release of renin from the renal juxtaglomerular apparatus, especially during volume depletion.However, the synthetic machinery and identity of the specific prostanoid released from intact MD cells remains uncertain.In the present studies, a novel biosensor tool was engineered to directly determine whether MD cells release PGE 2 in response to low luminal NaCl concentration ([NaCl] L ).HEK293 cells were transfected with the Ca 2+ -coupled E-prostanoid receptor EP 1 (HEK/EP 1 ) and loaded with fura-2.HEK/EP 1 cells produced a significant elevation in intracellular [Ca 2+ ] ([Ca 2+ ] i ) by 29.6 ± 12.8 nM (n = 6) when positioned at the basolateral surface of isolated perfused MD cells and [NaCl] L was reduced from 150 mM to zero.HEK/EP 1 [Ca 2+ ] i responses were observed mainly in preparations from rabbits on a lowsalt diet and were completely inhibited by either a selective COX-2 inhibitor or an EP 1 antagonist, and also by 100 µM luminal furosemide.Also, 20-mM graduated reductions in [NaCl] L between 80 and 0 mM caused step-by-step increases in HEK/EP 1 [Ca 2+ ] i .Low-salt diet greatly increased the expression of both COX-2 and microsome-associated PGE synthase (mPGES) in the MD.These studies provide the first direct evidence that intact MD cells synthesize and release PGE 2 during reduced luminal salt content and suggest that this response is important in the control of renin release and renal vascular resistance during salt deprivation.
THE ECONOMIC VALUE OF LIFE.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obstetrics and gynecology
Authors: G. R. Huggins
Journal: JAMA (1991)

The past year has seen exciting technological advances in the field of obstetrics and gynecology. Several advances in the areas of contraception, assisted reproduction, and the treatment of complications of prematurity are highlighted herein. On December 10, 1990, the Food and Drug Administration approved the Norplant Contraceptive System for use in the United States. This approval culminates 20 years of research and development. Since the first studies in 1966, the Norplant system has been used by more than 55 000 women in 46 countries. The Norplant system consists of six flexible Silastic capsules, each 34 mm long and 2.4 mm wide. Each capsule contains 36 mg of levonorgestrel, a synthetic progestin widely used in oral contraceptives. After subdermal insertion of the capsules, the blood levels stabilize at approximately 0.30 ng/mL, which corresponds to the level reached 12 hours after the oral intake of a levonorgestrel mini—contraceptive pill. The cumulative pregnancy
Physikalisch-diätetische Therapie nach klinischen Gesichtspunkten
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17613: Defining Clinical Indexes of Good Basket Placement that Predict Successful Outcome From Atrial Fibrillation Rotor Ablation
Authors: Amir A Schricker, Tina Baykaner, Junaid Zaman, Gautam Lalani, Kenneth Hopper, Antonio Moyeda, David E Krummen, Sanjiv M Narayan
Journal: Circulation (2015)

Introduction: Ablation for atrial fibrillation (AF) needs improvement, yet it is unclear what to ablate beyond the pulmonary veins since trials question fractionated electrograms or lines. Ablation of rotors and focal sources guided by contact baskets is promising, but with recent disappointing results in one study in which basket contact was poor. We related basket position to fluoroscopic landmarks to determine indexes of optimal placement that predict successful AF rotor ablation. Methods: We studied 60 AF patients (62±10 years, 65% persistent) in whom AF was mapped by 64-pole baskets of 48-60 mm diameter, sized by echocardiography or computed tomography. Cineangiograms were used to determine in blinded fashion if left atrial (LA) baskets lay near the floor (coronary sinus, Fig A) or not (Fig B), or if RA or LA baskets were deformed by the atria in 1 image (static) or during multiple cardiac cycles (dynamic; arrows in Fig C). Ablation comprised rotor targeting then PVI, with follow-up per guidelines. Results: Using bi-atrial baskets, 205 sources (LA 138; RA 67) were ablated (3.6±1.4/patient). In static images, LA baskets reached the floor in 44 (73%) and were deformed in 54 (90%). Dynamic basket deformation was seen in LA in 39 (65%) and RA in 51 (85%). Presence of LA deformation directly correlated with LVEF, inversely correlated with NYHA functional class (each p=0.05), and was related to good LA coverage. Single procedure AF-freedom at 1 year was higher in patients with dynamic LA deformation than in those without (80% vs. 57%; p=0.07), but unrelated to other indices. Conclusions: Atrial basket positioning is a new but important skill for implementing AF rotor ablation. This study is the first to systematically examine optimal indexes of good basket contact, and found that dynamic deformation of basket splines during systole predicted successful AF rotor ablation more effectively than other indexes.
Fatal malignant degeneration in multiple neurofibromatosis
Authors: M. J. Sands
Journal: JAMA (1975)

THIS report describes the development of sarcomatous degeneration of fibroma in a patient with multiple neurofibromatosis (Von Recklinghausen disease), and subsequent superior vena caval obstruction, tracheal compression, and circulatory and respiratory insufficiency. <h3>Report of a Case</h3> A 29-year-old, mentally retarded woman with neurofibromatosis sought medical advice in March 1973 because of exertional dyspnea. A chest x-ray film (Fig 1) showed a posterior mediastinal soft-tissue density overlying the apex of the right lung. Further diagnostic studies were declined by the patient and her family at that time. Dyspnea progressed over the next four months, with edema of the face, head, and neck, and the patient was admitted to Temple University Hospital on Nov 1, 1973. She was in moderate respiratory distress at bed rest. There were numerous pedunculated and sessile neurofibromata and café-au-lait spots covering the entire body. The face and hands were edematous, and the neck veins were distended at
THE BLACK DEATH
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hereditary Disorders of Bone Development. Part I. Diaphysial Aclasis Multiple Exostoses). Multiple Enchondromata, Cleido-Cranial Dysostosis.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal