tbuckley/cabot-search huggingface dataset:
Highlights
Journal: JAMA Pediatrics (2020)

Adverse Outcomes With Postnatal Cytomegalovirus Infection 133Weimer and colleagues conducted a multicenter cohort study of 304 infants with very low birth weight and postnatal cytomegalovirus infection.They found that cytomegalovirus infections were associated with an increased risk for failing results from a hearing screen and bronchopulmonary dysplasia, an increased postnatal age at discharge, and decreased weight for length at discharge compared with control infants without infection.
Successful treatment of 750 criminal addicts
Authors: V. P. Dole
Journal: JAMA (1968)

A four year trial of methadone blockade treatment has shown 94% success in ending the criminal activity of former heroin addicts. The majority of these patients are now productively employed, living as responsible citizens, and supporting families. The results show unequivocally that criminal addicts can be rehabilitated by a well-supervised maintenance program.
Increasing incidence of tuberculosis in a prison inmate population. Association with HIV infection
Authors: M. M. Braun
Journal: JAMA (1989)

The incidence of tuberculosis (TB) among inmates of the New York State prison system increased from 15.4 per 100 000 in 1976 through 1978 to 105.5 per 100 000 in 1986. Matching of TB and acquired immunodeficiency syndrome registries indicated that the majority (56%) of inmates with TB reported in 1985 and 1986 had acquired immunodeficiency syndrome or human immunodeficiency virus infection; none were known to be human immunodeficiency virus seronegative. A case-control study examined 59 inmates with TB reported from 1984 through 1986 and 59 matched control inmates without TB. Inmates who reported street drug use were more likely to develop TB: odds ratio, 9.7; 95% confidence interval, 2.8 to 33.6 and odds ratio, 7.3; 95% confidence interval, 0.9 to 59.3 by unconditional and conditional logistic regression analyses, respectively. Although the majority of cases are thought to be due to reactivation of latent infection, phage typing of 16<i>Mycobacterium tuberculosis</i>cultures suggested the possibility of inmate-to-inmate transmission in at least one cluster of three cases. It is of crucial importance that TB control measures be reinforced in the prison setting to counter the increased risk created by human immunodeficiency virus infection. (<i>JAMA</i>1989;261:393-397)
"CEREBRAL ANGIOSPASM"
Authors: Benjamin Finesilver
Journal: JAMA (1924)

<h3>To the Editor:</h3> —In a communication toThe Journal, May 31, page 1801, Dr. Holmes states that the observation of a patient during a cerebral angiospasm, as reported inThe Journal, May 17, page 1608, is not complete, and that the conclusion that the picture is one of cerebral angiospasm on the right side of the brain is not justified by the facts presented. He further asks whether one is justified in subscribing to the theory of angiospasm, without giving due consideration to the fact that maintenance of cerebral circulation is dependent on a normal circulating medium at an effective pressure and rate of flow in normal vessels. The question of cerebral circulation, whether dependent on a vasomotor mechanism in addition to the general circulation, or solely on the general circulation, has been a matter of long dispute. However, Hürthle (<i>Arch. f. die ges. Physiol.</i><b>41</b>:574, 1889), François-Franck (<i>Arch.</i>
Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation
Authors: H Goode
Journal: Hepatology (1994)

Endothelial injury occurs as a result of oxygen free radical production after ischemia and reperfusion of transplanted livers, causing hemodynamic disturbance. Patients with chronic liver disease generally have low levels of fat-soluble vitamins, which have important antioxidant roles. We therefore assessed circulating levels of the antioxidants vitamin A, vitamin E, β-carotene and lycopene, indices of lipid peroxidation and hemodynamic changes during elective orthotopic liver transplantation in 12 patients. We found that initial antioxidant levels were severely depleted compared with healthy subjects, and in some patients carotene and lycopene levels were undetectable. Increased lipid peroxidation was also evident, as shown by thiobarbituric acid–reactive substances. On reperfusion of the liver graft, vitamin A and E levels fell (p < 0.01) and were associated with decreases in systemic vascular resistance (p < 0.02). These data show that patients undergoing liver transplant have lowered antioxidant defenses and evidence of free radical damage, which compound the additional insult of reperfusion injury. Antioxidant therapy in these patients before transplantation may ameliorate the effects of reperfusion. (Hepatology 1994;19:354–359).
A radical explanation for glucose-induced β cell dysfunction
Authors: Michael Brownlee
Journal: Journal of Clinical Investigation (2003)

The development of type 2 diabetes requires impaired β cell function. Hyperglycemia itself causes further decreases in glucose-stimulated insulin secretion. A new study demonstrates that hyperglycemia-induced mitochondrial superoxide production activates uncoupling protein 2, which decreases the ATP/ADP ratio and thus reduces the insulin-secretory response. These data suggest that pharmacologic inhibition of mitochondrial superoxide overproduction in β cells exposed to hyperglycemia could prevent a positive feed-forward loop of glucotoxicity that drives impaired glucose tolerance toward frank type 2 diabete
Coronary artery spasm. Mechanisms and clinical relevance
Authors: E. Braunwald
Journal: JAMA (1981)

DURING the first half of this century, studies based on postmortem examinations of the hearts of patients who had experienced angina pectoris and myocardial infarction implicated fixed coronary artery stenoses secondary to arteriosclerosis as the cause of myocardial ischemia. Interest in the causal role of coronary artery spasm was stimulated by Prinzmetal et al<sup>1</sup>in 1959 who described a group of patients with angina at rest associated with ST-segment elevations. They postulated that this clinical syndrome, which they termed "variant angina," is due to spasm of a large, proximal, coronary artery. Subsequently, coronary arteriography provided unequivocal evidence of coronary artery spasm, thus establishing firmly the validity of the hypothesis by Prinzmetal et al. These important clinical observations were followed by studies on experimental animals that showed that coronary vascular resistance can be influenced notably by stimulation or blockade of the α-adrenergic nerves innervating the coronary vascular bed, indicating that
Thirty-Second Annual Scientific Meeting of the American Society of Cytology
Journal: JNCI Journal of the National Cancer Institute (1984)

Thirty-Second Annual Scientific Meeting of the American Society of Cytology Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 2, August 1984, Page 553, https://doi.org/10.1093/jnci/73.2.553-d Published: 01 August 1984
Skin Test Developed to Test Allergy to Penicillin
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Internal Medicine: Its Theory and Practice
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incomplete intrapulmonary lymph node retrieval with routine pathology evaluation of resected lung cancer.
Authors: R. A. Ramirez, C. Wang, L. E. Miller, C. A. Adair, T. O'Brien, A. Berry, R. U. Osarogiagbon
Journal: Journal of Clinical Oncology (2011)

7061 Background: Pathologic nodal stage predicts prognosis in patients with surgically resected lung cancer. While accurate mediastinal lymph node (LN) examination depends on surgical and pathology practices, intrapulmonary LN (N1) evaluation rests solely on pathologic inspection. A median of 5 N1 LNs were examined in the ACOSOG Z0030 trial and a median of 3 LNs were examined in the Memphis Metropolitan Area Quality of Surgical Resection cohort. We examined the frequency of unexamined N1 LNs (ULN1) in lung cancer specimens and how their examination impacts pathologic stage. Methods: Prospective case-control study of remnant resected lung cancer specimens was performed by special pathology examination (SPE) after routine pathology evaluation (RPE). SPE included additional gross dissection and light microscopy of LN-like material. ULN1 retrieved by SPE were compared to those recovered by RPE in study and an external control cohort matched for pathologist and extent of resection. Results: Additional ULN1 were retrieved in all patients (Table; N=29). Metastasis was discovered in 19 of 223 (8.5%) ULN1 from 28% of patients. Ten percent of patients were pathologically upstaged; two previously pN0 patients were found to have positive LNs and one patient was found to have a previously undetected satellite nodule. Adenocarcinoma and squamous cell carcinoma were found in 73% and 27% of ULN1, respectively. The median size of benign ULN1 was 0.6 cm (range 0.1-2.7 cm) and the median size of metastatic ULN1 was 1.2cm (range 0.1-2.4cm; p<0.0001). Median time for SPE was 30 minutes. Conclusions: RPE frequently leaves N1 LNs unexamined, a significant proportion of which harbor metastatic disease. Although LNs with metastasis tend to be larger than those without, the significant overlap precludes use of size as a discriminating characteristic. SPE improves N1 LN examination which may impact prognosis and adjuvant management. Improvement in RPE is needed in lung cancer resection. Median LN examined (range) Control 2 (0-13) RPE 4 (1-15) SPE 6 (1-46) RPE + SPE 10 (2-61) Median LN increase P value Control to RPE 2 <0.03 RPE to RPE + SPE 6 <0.0001 Control to RPE + SPE 7 <0.0001
Recent Developments in Cardiovascular Genetics
Journal: Circulation Research (2013)

The goal of "Recent Developments" is to provide a concise but comprehensive overview of new advances in cardiovascular research, which we hope will keep our readers abreast of recent scientific discoveries and facilitate discussion, interpretation, and integration of the findings.This will enable readers who are not experts in a particular field to grasp the significance and impact of work performed in other fields.It is our hope and expectation that these "Recent Developments" articles will help readers to gain a broader awareness and a deeper understanding of the status of research across the vast landscape of cardiovascular research.-
"Perimyocarditis"
Authors: ALBERT J. MILLER
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 August 1977"Perimyocarditis"ALBERT J. MILLER, M.D.ALBERT J. MILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-2-246_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I enjoyed reading the article by Sands and colleagues (Ann Intern Med 86:544-548, 1977) but question their wisdom in perpetuating the word "perimyocarditis." Their intent appears to be good, but "perimyocarditis" does mean "around the myocarditis," and that is surely not part of their intent. Ideally they should speak of "myocarditis and pericarditis"; less desirable, but perhaps acceptable, would be "myopericarditis."Perhaps they would agree that pericarditis with electrocardiographic changes must be due to an epicarditis, which must always mean some degree of myocarditis.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1977Volume 87, Issue 2Page: 246-246KeywordsElectrocardiographyMyocarditis Issue Published: 1 August 1977 PDF downloadLoading ...
FOREIGN CURRENT MEDICAL LITERATURE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Injuries Associated With Soccer Goalposts— United States, 1979-1993
Journal: JAMA (1994)

Injuries associated with sports can be related to a variety of factors, including participant's level of conditioning or training, failure to use safety equipment, contact, overexertion, difficulty in conducting the task required, mismatch in skill or size between players, and adverse environmental conditions. A rare but often fatal event is a blow caused by a falling soccer goalpost resulting from improper installation or use. From 1979 through 1993, 27 persons were injured or killed from falling soccer goalposts. This report describes three (two fatal) injuries associated with soccer goalposts and summarizes an analysis of all fatal and nonfatal soccer goalpost-related injuries reported in the United States to the Consumer Product Safety Commission (CPSC) during 1979-1993.
BOOKS RECEIVED
Journal: British Journal of Dermatology (1930)

Abstract Book received in this article: Asthma Research Council Report of Progress to May 31st, 1930 Diagnostica, e Tecnica di Laboratorio. Vol. I. Gennaio, 1930. Naples Das Gewerbeckzem. By Rudolph L. Mayer Cold in Relation to Skin-Diseases. By H. Haxthausen, M.D Cosmetics and Your Skin. By Herman Goodman, B.S., M.D Diseases of the Skin. A Text-hook for Practitioners and Students. By George Clinton Andrews, A.B., M.D Die Zerebrospinalflussigkeit. By Prof. Dr. MED. V. Kafka.
The use of doppler ultrasound for suspected testicular torsion: Lessons learned from a 15-year multicentre retrospective study of 2922 patients
Authors: U. Pinar, I. Duquesne, F. Lannes, F. Bardet, K. Kaulanjan, C. Michiels, E. Seizilles De Mazancourt, I. Dominique, M. Vallee, M. Felber, L. Freton, B. Gondran-Tellier, X. Matillon, Z-E Khene, B. Pradere
Journal: European Urology (2021)
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression
Authors: Heng Lin, Shuang Wei, Elaine M. Hurt, Michael D. Green, Lili Zhao, Linda Vatan, Wojciech Szeliga, Ronald Herbst, Paul W. Harms, Leslie A. Fecher, Pankaj Vats, Arul M. Chinnaiyan, Christopher D. Lao, Theodore S. Lawrence, Max Wicha, Junzo Hamanishi, Masaki Mandai, Ilona Kryczek, Weiping Zou
Journal: Journal of Clinical Investigation (2018)

TSC1KO BAL fluid infiltrates.Arrows and arrowheads represent neutrophils and macrophages, respectively.(E) Enhanced interstitial in TSC1KO lungs.Representative H&E staining of lung thin sections is shown.(F) mRNA levels of Il17a (increased) and Ifng (decreased) in the lungs of TSC1KO mice 5 hours after α-GalCer treatment.(G) Neutrophil numbers in the lungs after S. pneumoniae infection.Ctrl, uninfected; Infect, infected.(H) mRNA levels of indicated
Markers for transfusion-transmitted disease in different groups of blood donors
Authors: J. M. Starkey
Journal: JAMA (1989)

THERE is a growing interest in alternatives to homologous transfusion provided by volunteer donors. Autologous transfusions are increasingly in demand and some patients choose their own donors from among family and friends, a practice called<i>recipient-selected transfusions or directed donations</i>. Providing autologous transfusion for selected patients is medically sound. Patients who can safely donate for their own transfusion needs reduce their exposure to infectious disease. In contrast, no role has been established for directed donations in reducing the infectious complications of transfusion. An assessment of the risk of infection is particularly important, bearing in mind that autologous and directed donations, when not used by their intended recipients, are potentially available for the general blood supply. The number of donations available may be considerable, especially as many autologous collections are inappropriately made to cover elective surgery procedures that seldom require blood.<sup>1</sup> The practice of "crossing over" unused directed donor and
AUTHORS AND MEDICAL SUBJECTS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EDITORIAL NOTICE.
Authors: John B. Hamilton
Journal: JAMA (1889)

When the writer accepted the position of Editor of the Association Journal, although the Marine-Hospital Service bill was then pending, as it had been for the past ten years, he had no certainty of its passage, but, on January 4th it passed both houses of Congress and became a law, which by prohibiting any original appointments into the service except to the rank of Assistant-Surgeon, has the effect of creating a life tenure in the office of Supervising-Surgeon-General. He therefore tendered his resignation as Editor to the Board of Trustees and it was kindly accepted by them to take effect on a day named by himself. His editorial connection with The Journal will therefore cease with the present number, and until further notice, the "Committee on General Management" will take charge of the affairs ofThe Journal. With the most sincere thanks to those who have sent him kindly letters,
Hepatic interleukin-10 levels following bile duct ligation . Divisions of Gastroenterology &amp; Pulmonary Medicine, Departments of Medicine, Pathology &amp; Surgery. University of Michigan Medical Center, Ann Arbor, Michigan
Journal: Hepatology (1995)

Activation of hepatic lipocytes to myofibroblastlike cells observed in cell culture and during liver fibrogenesis is characterized by an increase in collagen formation and cell proliferation. These changes appear to be associated with the loss of intracellular retinoid in lipocytes, the principal storage site for vitamin A in the body. To evaluate whether retinoids have the capability to suppress lipocyte activation, we exposed cultured lipocytes in both native and myofibroblastlike states to retinoids and determined their effects on collagen production, intracellular retinoid level, and cell proliferation. Retinol (1 μM) and retinoic acid (1 μM) supplementation of primary rat lipocyte cultures inhibited the spontaneous increase in collagen synthesis associated with lipocyte activation; lower concentrations of retinol (10 or 100 nM) were also effective. Simultaneously, retinol addition prevented a precipitous decline in intracellular retinoid content in the absence of added retinoid. These retinoid effects were reversed by a change to unsupplemented control medium. When cells in the myofibroblastlike state were exposed to retinol (⩾ 1 μM), a significant increase in intracellular retinoid levels and reduction in collagen synthesis occurred. Lipocytes in both native and myofibroblastlike states secreted four to five times higher amounts of type I collagen than type III collagen, but retinol and retinoic acid particularly inhibited production of type I collagen. Cell proliferation measured by [3H]thymidine incorporation was also inhibited by retinol. These results demonstrate that extracellular retinoids suppress lipocyte-activated collagen synthesis and cell proliferation and support the interpretation that retinoids themselves are regulatory factors in maintenance of the lipocyte in its native, differentiated state.