tbuckley/cabot-search huggingface dataset:
Ocular Toxoplasmosis
Authors: RICHARD P. HANDLER
Journal: Annals of Internal Medicine (1979)

Letters1 August 1979Ocular ToxoplasmosisRICHARD P. HANDLER, M.D.RICHARD P. HANDLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-2-324_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A case of acquired chorioretinitis due to toxoplasmosis was reported in the January 1979 issue (1). I agree with the author that chorioretinitis does occur with acquired toxoplasmosis. It may be more common than realized, perhaps because physicians in primary care do not frequently contribute to journals. In 3 years of private practice of internal medicine, I have managed five cases of toxoplasmosis of which four were definitely acquired and in which in one case the patient developed loss of central vision in the right eye due to chorioretinitis. This case was confirmed by appropriate serologic tests...References1. GUMPHOLDEN DR. Acquired chorioretinitis due to toxoplasmosis. Ann Intern Med. 1979;90:58-60. LinkGoogle Scholar2. KRICKREMINGTON JJ. Current concepts in parasitology. Toxoplasmosis in the adult: an overview. N Engl J Med. 1978;298:550-5. CrossrefMedlineGoogle Scholar3. RYNINGMCLEODMADDOXHUNTREMINGTON FRJSJ. Probable transmission of Toxoplasmagondii by organ transplantation. Ann Intern Med. 1979;90:47-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Saranac Lake, NY 12983 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToxoplasma Uveitis Without Retinochoroiditis?ROBERT J. MASI, M.D., G. RICHARD O'CONNOR, M.D. 1 August 1979Volume 91, Issue 2Page: 324-324KeywordsPatient advocacyToxoplasmosisVision Issue Published: 1 August 1979 PDF downloadLoading ...
Sensitivity to Intravenous Anaesthetics
Journal: BMJ (1974)

announced, as well as £32,600 as three-year support from the Department of Health for the department of psychological medicine's psycho-geriatric research programme.Eyes at the Westminster Just 250 years ago William Cheselden per- formed the first ophthalmic operation to be done in the then recently opened Westminster Hospital.The leading oculist of his day thus began an unbroken succession of eye surgery at the Westminster.Four years after Cheseldens' arrival Thomas Hope was also ap- pointed oculist to the hospital, so that 50% of the consultant surgeons there were then opthalmologists.These and later events are commemorated in a pamphlet produced priv- ately by Mr. P. Trevor-Roper, consulting ophthalmic surgeon to the hospital.
Single-institution experience with FOLFIRINOX in advanced pancreatic cancer (PC).
Authors: Krishna Soujanya Gunturu, Jaykumar Ranchodbhai Thumar, Howard S. Hochster, Stacey Stein, Xiaopan Yao, Xiangyu Cong, Carol Hahn, Kristin Kaley, Jill Lacy
Journal: Journal of Clinical Oncology (2012)

330 Background: FOLFIRINOX provides clinically significant benefit in advanced PC compared to gemcitabine (Conroy et al. New Engl J Med 2011;364:1817). Despite superior efficacy, toxicities have tempered enthusiasm for FOLFIRINOX and limited its use in full doses. To assess the impact of dose attenuations on toxicity and efficacy, we reviewed our experience with FOLFIRINOX in pts with advanced PC. Methods: We performed a retrospective review of dose, toxicity, efficacy of FOLFIRINOX in all pts with locally advanced unresectable PC (LAPC) and metastatic PC (MPC) treated with FOLFIRINOX at Yale Cancer Center between 06/10 and 06/11. Dose attenuations were at the treating physician’s discretion. All pts received prophylactic pegfilgrastim. Pts were treated until progression, unacceptable toxicity, or surgical resection. Toxicities and efficacy were compared to historical data reported by Conroy. Results: 31 pts with ECOG PS 0 or 1 were treated. Pt characteristics: LAPC 15; MPC 16; median (med) age 60 yrs (range 48-78); male 11; prior chemotherapy 5 (adjuvant 3). Med number of cycles received was 6 (range 1-18). Only 5 pts received full doses of all drugs with cycle 1. Dose reductions with cycle 1 were: IRI 26 pts, OX 10 pts, bFU 10 pts, infusional FU 1 pt. b5FU was omitted in 6 pts. Med relative dose intensities were: OX 88%, IRI 64%, b-FU 57%, infusional FU 100% (compared to OX 78%, IRI 81%, and FU 82% [Conroy]). The % of pts with grade 3 or 4 toxicities was: fatigue or mucositis, 9.6%; dehydration or neutropenia 6.4%; vomiting, thromboembolism, febrile neutropenia, thrombopenia or anemia, 3.2%. Neutropenia (p&lt;0.0001), diarrhea (p&lt;0.03), fatigue (p&lt;0.02) were significantly decreased compared to historical data (Conroy). Response (CR+PR) in 30 evaluable pts was 33% (1 CR, 9 PR, 14 SD, 6 PD) and similar to historical data (31.6%; p 0.21). 2 pts with LAPC underwent resection. Evaluation for OS and PFS is ongoing. Conclusions: Our findings suggest that dose attentuation of FOLFIRINOX, esp IRI and bFU, with prophylactic pegfilgrastim is associated with improved tolerability and equivalent response rate compared to full dose FOLFIRINOX in advanced PC. The impact of dose attenuations on toxicity and efficacy warrants further evaluation in both LAPC and MPC.
Clinical Nutrition
Authors: S. Abraham
Journal: JAMA (1990)

One cannot but be enthusiastic about this book. The chapters are almost all uniformly very good or excellent and are a tribute to the contributors and, in particular, to the editor. The book is a veritable gold mine of information presented in an easy to read fashion with a comprehensive but critical review of the major aspects of the nutritional status of the patient. I particularly enjoyed reading the chapters under Part IV ("Systemic Disorders and Nutrition") and those on anemias and on obesity. My major criticism is of the references in many chapters—too few and too old! Some chapters, such as that on vitamin deficiencies, have over 200 references, some around forty, others only around ten! In addition, most of the references are from the 1960s and 1970s, with scattered citations of papers from the early 1980s. True, basic facts in medicine do not always change that much even
Obituaries Obituaries
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes Mellitus
Authors: Samuel B. Beaser
Journal: New England Journal of Medicine (1952)

IN THIS report the following aspects of diabetes mellitus are considered: biochemistry and physiology; pathology and pathogenesis; experimental diabetes; diagnosis; treatment; associated conditions; surgery in diabetes; pregnancy in diabetes; and complications.Biochemistry and Physiology Carbohydrate Metabolism The recent use of C14-glucose has advanced understanding of carbohydrate metabolism. For example, it has yielded more accurate estimates of the disposal of fed carbohydrate in the normal organism: 80 per cent is oxidized,1 , 2 and 17 per cent3 and 3 per cent converted to fatty acids and glycogen, respectively. In vivo studies of diabetic animals showed a double turnover rate of glucose that . . .
Epidemic Sporotrichosis
Authors: Bruce E. Hodges
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Two epidemics of sporotrichosis have recently been reported. Nine children were infected while playing in tunnels of stacked bales of prairie hay,<sup>1</sup>and six college freshmen were infected by contact with contaminated moss, soil, and straw used as brick packing.<sup>2</sup>The combination of unusual circumstances roused the physicians' Muse, and rhymed verse soon appeared inThe Journalentertainingly warning of the dangers of the "tricky Sporothrix"<sup>3</sup>and the pitfalls of its nomenclature.<sup>4</sup> Coincident with the outburst of articles and poems, two additional cases of sporotrichosis related to prairie hay were observed. Three sisters ages 5, 7, and 12 years, spent one day (Jan 24, 1971) playing and burrowing in a stack of prairie hay on a relative's farm in eastern Kansas. Approximately ten days later, the oldest girl developed an erythematous papule just below her lower lip and the youngest girl developed a
Hepatic and extrahepatic HCV RNA strands in chronic hepatitis C: Different patterns of response to interferon treatment
Authors: B Gil
Journal: Hepatology (1993)

We investigated the presence of positive (genomic) and negative (replicative intermediate) hepatitis C virus RNA strands in liver, peripheral mononuclear cells and serum from patients with chronic hepatitis C using a selective and semiquantitative polymerase chain reaction procedure. Negative and positive hepatitis C virus RNA strands were present in liver, serum and lymphoid cells in all untreated patients and in all those who did not respond to interferon therapy. In the latter group of patients, the titers of RNA strands in the liver and peripheral mononuclear cells at the end of the treatment were similar to those encountered in untreated patients, but the serum titers were about 100 times lower than pretreatment values. In patients who responded to interferon with normalization of serum aminotransferase levels (n = 10), the rate of detection and the titer of the two viral strands in liver, serum and mononuclear cells were markedly decreased at the end of the therapy. In the six responders who did not relapse after interferon withdrawal, both hepatitis C virus RNA strands were absent from the liver, serum and lymphoid cells. By contrast, the positive RNA strand was present in liver cells, mononuclear cells or both at the end of therapy in all patients who experienced posttherapy relapse. In conclusion, our results indicate that interferon can clear hepatitis C virus from hepatic and extrahepatic sites only in responder patients. Disappearance of genomic hepatitis C virus RNA from the liver and from mononuclear cells may predict complete response without posttherapy relapse. (HEPATOLOGY 1993;18:1050-1054).
MEDICAL SHOCK
Authors: DANA W. ATCHLEY
Journal: JAMA (1930)

Medical shock is a term denoting for the internist the complication which, when it occurs in surgery, is called surgical shock. Shock, whenever it occurs, is a serious and often fatal condition characterized by vasomotor collapse, drop in blood pressure and consequent failure of the circulation. Doubtless there are better terms than medical shock, but the well known connotation of "shock" makes it a word difficult to discard. Although shock is a frequent and long recognized terminal event in disease, the lack of emphasis put on it in nearly all textbooks and in contemporary medical literature leads to this reexamination of the problem. I hope to point out, moreover, that the mechanism of this event in medical conditions is such that therapy is much more successful than in the occurrence of other causes of death, such as cardiac or respiratory failure, with which, indeed, it is often confused. My attention
Abstract 2208: Peptide-mediated 'miniprep' isolation of extracellular vesicles is suitable for high-throughput proteomics; method evaluation and application in colon cancer
Authors: Meike De Wit, Jaco Knol, Inge de Reus, Tim Tim Schelfhorst, Logan Bishop-Currey, Nicole van Grieken, Sander Piersma, Thang V. Pham, Remond J. Fijneman, Gerrit A. Meijer, Henk Verheul, Connie R. Jimenez
Journal: Cancer Research (2017)

Abstract Objective: Extracellular vesicles (EVs) are cell-secreted membrane vesicles enclosed by a lipid bilayer derived from endosomes or from the plasma membrane. Since they are released into body fluids, and their cargo includes tissue-specific and disease-related molecules, EVs represent a rich source for disease biomarkers. However, standard ultracentrifugation methods for EV isolation (UC-EV) are laborious, time-consuming, and require high inputs. Method: A recently described isolation method, which can be performed at small ‘miniprep’ scale, utilizes specific Heat Shock Protein (HSP)-binding peptides to aggregate HSP-decorated EVs (Ghosh et al. (2014), PLoS ONE 9:e110443). The authors showed comparable results for their method (abbreviated HSP-EV here) and UC-EV, but a detailed proteomic comparison was lacking. Therefore, we compared both methods using label-free proteomics of replicate EV isolations from HT-29 cancer cell-conditioned medium. Subsequently we applied this technique on secretomes of fresh human colorectal cancer (CRC) (n=17) and colon adenoma (n=4) tissue as well as patient-matched normal colon tissue. Results: Despite a 30-fold different input scale (UC-EV: 60 ml versus HSP-EV: 2 ml), both methods yielded comparable numbers of identified proteins (3115 versus 3085), with reproducible identifications (72.5% versus 75.5%) and spectral count-based quantification (average CV 31% versus 27%). EVs obtained by either method contained established EV markers and proteins linked to vesicle-related gene ontologies. In the EV fraction of the tissue secretomes 6390 proteins were identified, of which 471 proteins were significantly 5-fold more present in CRC samples than in normal tissue EVs. Gene ontology analysis revealed enrichment of nuclear proteins involved in DNA damage response, chromosome organization and RNA processing in the CRC EVs. Conclusions: The HSP-EV method provides an advantageous, simple and rapid approach for EV isolation from small amounts of biological samples, enabling high-throughput analysis in a biomarker discovery setting. Citation Format: Meike De Wit, Jaco Knol, Inge de Reus, Tim Tim Schelfhorst, Logan Bishop-Currey, Nicole van Grieken, Sander Piersma, Thang V. Pham, Remond J. Fijneman, Gerrit A. Meijer, Henk Verheul, Connie R. Jimenez. Peptide-mediated 'miniprep' isolation of extracellular vesicles is suitable for high-throughput proteomics; method evaluation and application in colon cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2208. doi:10.1158/1538-7445.AM2017-2208
Tissue expansion: "future of plastic surgery for next 20 years'
Authors: M. Cherskov
Journal: JAMA (1982)

New tissue stretching devices may enhance the ability of plastic surgeons to treat skin defects caused by trauma, cancer, or congenital events. A two-step surgical technique, outlined by Eric D. Austad, MD, at a recent seminar in Chicago, utilizes expandable silicone shells or bags that are implanted subcutaneously to produce excess tissue around a site of injury. The shells are filled with sodium chloride so that inflation occurs via osmosis at a rate of 5 to 10 cc per day. After a six- to 12-week stretching period, the "balloons" are removed and the stretched skin used in a primary closure. The procedure minimizes the problems inherent in grafting and muscle flap techniques, namely, skin color mismatch and trauma at the grafting site. By use of tissue expansion devices, natural physiological skin stretching mechanisms, like those that occur during weight gain or pregnancy, are mimicked. In such natural processes, "skin or
Review: Vasomotor symptoms peak at 1 year after final menstrual period and may persist for many years
Authors: Carolyn J. Crandall
Journal: Annals of Internal Medicine (2008)

ACP Journal ClubDecember 16, 2008Review: Vasomotor symptoms peak at 1 year after final menstrual period and may persist for many yearsCarolyn J. Crandall, MD, MSCarolyn J. Crandall, MD, MSUniversity of Los Angeles, Los Angeles, California, USA (C.J.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-12-200812160-02015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationPoliti MC, Schleinitz MD, Col NF. Revisiting the duration of vasomotor symptoms of menopause: a meta-analysis. J Gen Intern Med. 2008;23:1507-13. https://pubmed.ncbi.nlm.nih.gov/18521690Clinical Impact RatingsEndocrinology: References1 Berg G, Gottwall T, Hammar M, Lindgren R, Gottgall T. Climacteric symptoms among women aged 60-62 in Linköping, Sweden, in 1986. Maturitas. 1988;10:193-9. [PMID: 3185293] Google Scholar2 Avis NE, Stellato R, Crawford S, et al. Is there a menopausal syndrome? Menopausal status and symptoms across racial/ethnic groups. Soc Sci Med. 2001;52:345-56. [PMID: 11330770] Google Scholar3 Gold EB, Sternfeld B, Kelsey JL, et al. Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40-55 years of age. Am J Epidemiol. 2000;152:463-73. [PMID: 10981461] Google Scholar4 Utian WH, Archer DF, Bachmann GA, et al. Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society. Menopause. 2008;15:584-602. [PMID: 18580541] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Los Angeles, Los Angeles, California, USA (C.J.C.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics December 16, 2008Volume 149, Issue 12Page: JC6-15KeywordsAdverse eventsAgingClinical trial reportingEndocrinologyForecastingHealth care quality assessmentHormonal therapyHormonesLongitudinal studiesMenopauseMotivationObstetrics and gynecologySweat Issue Published: December 16, 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
COUNCIL ON PHARMACY AND CHEMISTRY
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New York Academy of Medicine.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency Surgery in a Community Hospital
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Underweight, Overweight, Obesity, and Excess Deaths—Reply
Authors: Katherine M. Flegal, Barry I. Graubard, Mitchell H. Gail, David F. Williamson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal