tbuckley/cabot-search huggingface dataset:
Antiaging
Authors: Leigh Turner
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Authors: Wilma Bergfeld, Drs Ryan
Journal: British Journal of Dermatology (1984)

A Course on common and important fungal infections will be held at Fitzwilliam College, Cambridge on 26-28 September 1984.The Course will be of value to clinicians in various disciplines, and it is not primarily concerned with the technical aspects of identification of fungi.The Course emphasizes the definition of the clinical problem, and the role of the laboratory in diagnosis and management.The fee including accommodation and meals will be £127.50.
BELGIUM
Journal: JAMA (1925)

<h3>Brussels Medical Conference</h3> The Brussels medical conference, or the Journées médicales so called, is meeting with increasing success every year. It synthesizes national medical activities. In addition to the national representation, many foreign scientists take part in the convention. The collaboration of French scientists constitutes a strong link between French and Belgian physicians. The Journées médicales have been developed to organize for physicians located at some distance from the medical centers a practical general review, in the form of a few days spent in the hospitals, of the progress of medicine during the current year. In this connection, the collaboration of the four Belgian universities has been a powerful aid. The opening meeting, which was attended by the queen, took on a ceremonial character, which was partly due to the fact that it was held in the Palais des Académies. Many foreign delegates were present: Drs. Vincent (France), Bandelac de
Acute Renal Failure
Authors: Stanley S. Franklin, John P. Merrill
Journal: New England Journal of Medicine (1960)

PathophysiologyAnuriaThe pattern of anuria followed by an eventual diuretic period and recovery of function has a striking similarity regardless of the variety of factors entering into the pathogenesis of acute renal failure. Pathological changes, as described in Oliver's microdissection studies,118 consist of two distinctive tubular lesions. When a nephrotoxin produces renal failure a large segment of proximal tubule shows a uniform cellular necrosis down to, but not including, the basement membrane. When ischemia is associated with renal failure there is a complete disruption of tubular continuity, including dissolution of the basement membrane, with secondary ingrowth of Connective-Tissue elements. . . .
Binoculars
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some Aspects of the Problem of Regulation of Food Intake and Obesity
Authors: Jean Mayer
Journal: New England Journal of Medicine (1966)

IN 1953 I attempted to present inclusively evidence then available on the nature and the pathogenesis of obesity.1 I also attempted to introduce new ideas, some of them at the time frankly controversial, into a subject that I then considered to be in a state that could only be characterized as "stultified chaos."On one side were the fundamentalists, who saw only the undeniable fact that, as first pointed out by Lavoisier in the eighteenth century, matter and energy are not created de novo in biologic systems; for obesity to develop, energy intake has to be greater than output. Blandly . . .
Present Status of Different Mass Screening Procedures for Phenylketonuria: Medical Research Council Working Party on Phenylketonuria
Authors: Alan Moncrieff, R Illingworth, J Blainey, F Brimblecombe, I Carr6, Barbara Clayton, J Farquhar, K Holt, F Hudson, G Komrower, I Macdonald, T Noble, L Penrose, F Riley, J Roberts, J Scott, J Stevenson, I Sutherland, A Watkins, L Wolff, Katherine Wolff
Journal: BMJ (1968)

The Phenistix screening test for phenylketonuria in newborn infants, when used routinely at the recommended age of 4 to 6 weeks, passes as normal a substantial proportion-perhaps between a quarter and a half-of children with the disease, who are then diagnosed only after brain damage has occurred. Screening procedures based on three other tests-namely, the paper chromatography test for o-hydroxyphenylacetic acid in urine, the Guthrie test for phenylalanine in blood, and a modification of the Guthrie test for phenylalanine in urine-have been compared with each other and with the Phenistix test in a special field inquiry. Each of the three tests is more efficient than the Phenistix test for the detection of phenylketonuria at an early age.A full appraisal indicates that the Guthrie test on blood would be the most satisfactory of the three tests to replace the Phenistix test as a screening procedure. Routine use of this would involve comprehensive arrangements for obtaining a single specimen of blood by heel-prick from every newborn infant at the age of 6 days or more, but preferably not later than 14 days, and for the rapid and economical processing of the specimens and skilled interpretation of the results at a few laboratory centres. These requirements have not proved difficult to meet in practice in the area where this procedure has been studied.A positive screening test result does not signify a firm diagnosis of phenylketonuria, but is an indication for fuller investigation, most suitably at one of a small number of centres specializing in the management of phenylketonuria and other inborn errors of metabolism.
Brain Trauma
Authors: Mike Mitka
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicolegal.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P01.031 VXM01 phase I study in patients with progressive glioblastoma - final results
Authors: W Wick, A Wick, F Sahm, D Riehl, A von Deimling, M Bendszus, P Mickingereder, P Beckhove, F Schmitz Winnenthal, C Jungk, S Wieckoswski, A Keller, L Podola, C Herold-Mende, H Lubenau, A Unterberg, M J Platten
Journal: Neuro-Oncology (2018)

VXM01 consists of the attenuated Salmonella Typhi strain Ty21a carrying a plasmid encoding vascular endothelial growth factor receptor 2 (VEGFR2). The bacterium serves as a vector to deliver the plasmid into the Peyer's patches via the oral route of administration. The vaccine elicits a systemic T-cell response targeting VEGFR2. This trial examined safety and tolerability, clinical and immunogenic responses to VXM01 after at least four vaccinations at 106 or 107 colony-forming units in patients with progressive glioblastoma who have failed at least radiochemotherapy with temozolomide and who are candidates for a reoperation. Patients with progressive operable glioblastoma were subjected to VXM01 in one oral administration each on day 1, 3, 5, and 7. In addition, VXM01 was allowed to be administered in 4-weekly single doses during the tumor follow-up period after surgery. Follow-up was done by weekly safety laboratories and physical examinations in the treatment period and 4-weekly thereafter, MRI, T-cell immunomonitoring in the peripheral blood by IFN-γ ELISpot, and brain tumor immunohistochemistry. Fourteen patients have been treated with VXM01. Three out of them with additional nivolumab. Surgery has been performed in eight patients. Under VXM01 treatment 129 adverse events, mostly unrelated to VXM01, were observed after a median of 7.5 doses per patient. ELISpot analysis showed a detectable VEGFR2-specific T cell response in 7 out 12 (58%) patients measured. In the observation period up to 2 years, seven patients are alive and survived for more than 12 months after initiation of treatment. Survival seemed to be correlated with a higher CD8/Treg ratio in progressive and primary tumor, which further increased after VXM01 treatment. In patients with prolonged survival a decrease in intratumoral PD-L1 was measured arguing for combination of VXM01 with an anti-PD-L1 checkpoint inhibitor. A strong partial response was observed in one patient under VXM01 monotherapy, further improved in a complete response after addition of nivolumab to VMX01. VXM01 was safe and produces detectable specific peripheral immune responses and increased T-cell infiltration in post-vaccine tumor tissue. There was one patient with an objective response. As a next step, a combination study of VXM01 and anti-PD-L1 checkpoint inhibitor avelumab in 30 patients with relapsed glioblastoma has been launched.
Do Everything
Authors: Matthew K. Wynia
Journal: Annals of Internal Medicine (1994)

Letters1 December 1994Do EverythingMatthew K. Wynia, MDMatthew K. Wynia, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-11-199412010-00042 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Fronduti raises an important issue. I believe that a (misplaced) fear of litigation caused the situation I described to arise. Any decision we make in patient care, however, may put us in a perilous position—especially if the patient or surrogate is not informed. All decisions taken unilaterally are risky, not only those involving CPR. The patient or surrogate must be given the opportunity to question, learn, to assimilate, and to object when discussing treatments. This does not mean that treatment decisions are theirs alone or that they should necessarily be posed as questions. Cardiopulmonary resuscitation is unique ... Author, Article, and Disclosure InformationAuthors: Matthew K. Wynia, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1994Volume 121, Issue 11 Page: 900-901 ePublished: 15 August 2000 Issue Published: 1 December 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
DENMARK
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"AURICULAR FLUTTER AND FIBRILLATION IN PREGNANCY"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The migrainous scintillating scotoma
Authors: C. D. Aring
Journal: JAMA (1972)

The scintillating scotoma of migraine may occur without headache, particularly in persons beyond middle age. As an aid in recognition of the disorder, it may become necessary to assist the patient with the description of his symptom. The physician unfamiliar with the vagaries of migraine is apt to confuse this partial syndrome with transient ischemic attacks due to insufficient blood flow to the brain, most often associated with obstruction(s) in arteries traversing the neck. Intraoptic disorders and the episodic blindness of giant-cell arteritis are considerations in differential diagnosis. There should be no diagnostic confusion if the patient's history is developed carefully.
Aviation Medicine
Authors: Roy L. DeHart
Journal: JAMA (1988)

"This book is intended to provide a basic reference textbook for those engaged in the practice of aviation medicine or of occupational medicine when it relates to aviation": so state the editors of this second edition. This task has been admirably accomplished by our British colleagues. The book is a welcome enhancement of the original in form, style, and content. The text is now published in the larger, more standard 7 1/2 × 10—inch format and combines both aviation physiology and clinical medicine into a single volume. In addition to a much needed section on aircraft accident investigation and aviation pathology, the work-rest subject area has been expanded and the material on aviation psychology rewritten. Although not uniform, many chapters now include references or recommended readings. The reader will find the text well outlined in a major heading-subheading format. Unfortunately, this has not been carried forward in the table of
Medical News
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new form of Ehlers-Danlos syndrome. Fibronectin corrects defective platelet function
Authors: M. A. Arneson
Journal: JAMA (1980)

In a kindred with a mild, recessively inherited variant of the EhlersDanlos syndrome (EDS), a platelet aggregation defect segregated concordantly with skin and joint abnormalities. This defect was partially corrected in vitro by addition of normal plasma or cryoprecipitate. The plasma of the patients with EDS failed to support the aggregation of normal gel-filtered platelets in response to collagen; this defect was completely corrected by the addition of normal human fibronectin. Since fibronectin is an important adhesive glycoprotein in connective tissue and is required for normal platelet interactions with collagen, we propose that both platelet malfunction and joint hypermobility in this kindred are likely explained by a defective fibronectin. (<i>JAMA</i>244:144-147, 1980)
BOOK REVIEWS
Authors: C. E. REED
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Thoracic Oncology. Jack A. Roth, John C. Ruckdeschel, Thomas H. Wezcenburger, Philadelphia: W. B. Saunders Co., 1989, 723 pp. $90. CAROLYN E. REED CAROLYN E. REED Medical University of South Caroilna Division of Cardiothoracic Surgery171 Ashley Ave. Charleston, SC 29425 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 18, 20 September 1989, Pages 1418–1419, https://doi.org/10.1093/jnci/81.18.1418 Published: 20 September 1989
Animals in research
Authors: Dallas Pratt
Journal: JAMA (1988)

<h3>To the Editor.—</h3> AsAs a physician, I would like to respond to the article entitled "Animals in Research" by Drs Smith and Hendee.<sup>1</sup>It was addressed to American physicians and scientists, urging them "to assume a primary role in defending the use of animals for biomedical research." Unfortunately, the article contains a number of misleading statements and omissions of significant facts. For example, it states that "the public has insisted on assurance that animals are treated humanely.... The Animal Welfare Act and its amendments as well as Public Health Service policy and regulations put the weight of the law behind such assurances." Rats and mice, which make up the vast majority of experimental animals, have been declared by the Secretary of Agriculture "not to be animals" with respect to this legislation and receive no protection whatsoever from these laws. Horses, cattle, chickens, and many others are also excluded. Under