tbuckley/cabot-search huggingface dataset:
Editorial Board EOV
Journal: The American Journal of Bioethics (2011)

ed/Indexed in: Bibliography of Bioethics; BIOSIS/Biological Abstracts; CINAHL; EMBiology; EMCARE; ISI Science Citation Index; ISI Current Contents/Social & Behavioral Sciences; ISI Social Science Citation Index; MEDLINE/PubMed; OCLC Article First; OCLC Electronic Collections Online; The Philosopher’s Index; PAIS International; Scopus; Abstracts and InFocus pieces are searchable through major internet search engines.
Laser Surgery
Authors: K. K. Jain
Journal: JAMA (1984)

<h3>To the Editor.—</h3> In response to the QUESTIONS AND ANSWERS article entitled "Cerebrovascular Arteriovenous Malformations and Laser Surgery,"<sup>1</sup>I would like to comment on some of the statements made by the consultants. Dr Mullan's statement in referring to lasers—"but since all are relatively superficial, they have a greater capacity to burn through rather than coagulate"—is incorrect. It is possible to occlude a vessel with the neodymium:yttrium-aluminum-garnet (Nd: YAG) laser without burning a hole through it and even without producing intraluminal thrombosis. The mechanism is heat-induced contraction of the collagen of the blood vessel. His other statement—"The laser's main advantage is in removing fine particles of tumor from nerve structure"—is not an adequate description of the current status of lasers in neurosurgery. The CO2 laser, by virtue of avoidance of mechanical contact with tissues, is ideal for safe removal of tumors located in critical areas of the CNS. Many other
Efficacy of Tyrosine Kinase Inhibitor Therapy in a Chemotherapy-refractory B-cell Precursor Acute Lymphoblastic Leukemia With ZC3HAV1-ABL2 Fusion
Authors: Gauthier Decool, Carine Domenech, Nathalie Grardel, Adriana Plesa, Imelda Raczkiewicz, Benoit Ducourneau, Philippe Ruminy, Marie-Pierre Pages, Sandrine Girard, Laurène Fenwarth, Claude Preudhomme, Yves Bertrand, Nicolas Duployez
Journal: HemaSphere (2019)
Intra-aortic Balloon Counterpulsation— A Weaning "Assist"
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician migration to the United States. One country's transfusion is another country's hemorrhage
Authors: H. A. Ronaghy
Journal: JAMA (1974)

THERE are now nearly 47,000 foreign-trained physicians who have permanent residency status and are licensed to practice medicine in the United States.<sup>1</sup>In the past 20 years, the number of foreign medical graduates (FMG) receiving license to practice increased from an annual rate of 300 in 1950 to 3,000 in 1970.<sup>1</sup>Thus, in 1970, twenty-seven percent of the 11,000 new licentiates in the United States were FMG as compared to 5% of 6,000 new physicians granted licenses in 1950.<sup>1</sup>Now almost one-third of all US house staff are FMG.<sup>1</sup>The extensive role played by the FMG in the health care system of the United States has been discussed from the point of view of the receiving country in a recent article by Dublin.<sup>2</sup>Our study addresses the issue from the viewpoint of one of the major donating countries. At present Iran ranks fifth among all
The Oxford Index of Therapeutics.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence and prognostic impact of cancer after liver transplantation
Authors: Manuel Rodríguez-Perálvarez, Gonzalo Crespo, Tommaso Di Maira, Patricia Salvador, Sheila Pereira, Ainhoa Fernandez, Trinidad Serrano, Jose Ignacio Herrero, Rocio González-Grande, Maria Angeles Lopez Garrido, Ruben Ciria, Carmen Bernal, Aránzazu Caballero-Marcos, Sara Llorente Perez, Jordi Colmenero, Maria Senosiáin, Flor Nogueras López, Susana Lopez Ortega, Mercedes Iñarrairaegui, Victoria Aguilera Sancho, Andres Valdivieso Lopez, María Dolores Espinosa Aguilar, Cristina Borao, Miguel Jiménez, Jesús Rivera, Magdalena Salcedo, Fernando Rotellar, Manuel De La Mata Garcia, Mikel Gastaca, Miguel Navasa, Marina Berenguer Haym, Miguel Angel Gómez-Bravo
Journal: Journal of Hepatology (2020)
Synergistic Signals in the Environment
Authors: Steven F. Arnold, John A. McLachlan
Journal: Environmental Health Perspectives (1996)

Numerous endogenous signals (such as hormones and growth factors) or environmental signals (including chemicals or temperature) contribute to determining the overall biological response produced by cells. Some combinations of endogenous or environmental signals produce synergistic activity. This commentary examines the different types of interactions between signals that contribute to synergy at the biological level.
Local medical committee conference
Journal: BMJ (1999)

Local medical committee conference PCG deal wins overwhelming supportRepresentatives of Britain's GPs have given their support to the government's reassurances on primary care groups (PCGs) and resolved that they form an acceptable basis for GPs' involvement.Last week's local medical committee (LMC) conference congratulated the GP leaders on their negotiations, which resulted in reassurances on freedom, funding, and control.These were set out in a letter from the health minister, Mr Alan Milburn, and were welcomed by the General Medical Services Committee at an emergency meeting last month (27 June, p 1927).
Commentary
Authors: J A Maclean
Journal: British Journal of Sports Medicine (2001)

Objective-To analyse all clinical presentations to the crowd doctors at Scotland's largest football stadium over the course of one complete season.Methods-A standard clinical record form was used to document all consultations with the crowd doctors including treatment and subsequent referrals.The relevance of alcohol consumption was assessed.Results-A total of 127 casualties were seen at 26 matches, a mean of 4.88 per match.Twenty casualties were transferred to hospital, including one successfully defibrillated after a cardiac arrest.Alcohol excess was a major contributing factor in 26 cases.Conclusions-The workload of the crowd doctors was very variable and diverse.The social problem of excessive alcohol consumption contributed considerably to the workload.The provision of medical facilities at football grounds means that attendance there is now one of the least adverse circumstances in which to have a cardiac arrest.The study confirmed previous impressions that more casualties are seen at high profile matches.
Ethics and Society
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy of Adjuvant Fluorouracil and Folinic Acid in B2 Colon Cancer
Journal: Journal of Clinical Oncology (1999)

PURPOSE: The goal of this analysis was to determine whether fluorouracil (FU) and folinic acid (leucovorin, LV) is an effective adjuvant therapy for patients after potentially curative resection of colon cancer in patients with B2 tumors. PATIENTS AND METHODS: One thousand sixteen patients with B2 colon cancer entered onto five separate trials were randomized to FU + LV or observation. A pooled analysis for event-free (EFS) and overall survival (OS) using a stratified log-rank and Cox model was performed. RESULTS: The median follow-up duration was 5.75 years. Patients receiving FU + LV did not experience a significant increase in EFS or OS. The hazards ratio at 5 years was 0.83 (90% confidence interval, 0.72 to 1.07) for EFS and 0.86 (90% confidence interval, 0.68 to 1.07) for OS. The 5-year EFS was 73% for controls and 76% for FU + LV. The 5-year OS was 80% for controls and 82% for FU + LV. Increasing age and poorly differentiated tumors were significant indicators of poor prognosis (P &lt; .02). CONCLUSION: This data set does not support the routine use of FU + LV in all patients with B2 colon cancer. Longer follow-up may identify a small benefit. At present, studies in B2 colon cancer designed with a no-treatment control arm should be considered appropriate.
Gastric leiomyoblastoma
Authors: B. Bose, J. Candy
Journal: Gut (1970)

This paper describes two cases of gastric leiomyoblastoma (bizarre smooth muscle tumour), one of them having evidence of metastases. Both patients remain well after seven years and three and a half years respectively. The literature is reviewed, and the clinical features, diagnosis, and treatment are discussed. The histological appearances are described in detail and an attempt is made to assess the criteria for the diagnosis of malignancy.
Treatment of Hyperlipemia
Authors: Simeon Margolis
Journal: JAMA (1978)

PREVENTION of premature vascular disease is the major goal in the treatment of hyperlipemia. Epidemiologic studies provide convincing evidence that hypercholesterolemia is a major risk factor for coronary heart disease (CHD).<sup>1</sup>In fact, clinical manifestations of CHD parallel the serum cholesterol levels even within the "normal range" of serum cholesterol. Although no studies have proved that reduction of serum cholesterol levels decreases CHD or increases longevity, the overwhelming evidence linking hypercholesterolemia with premature CHD suggests that we should initiate efforts to lower serum cholesterol levels while we await final proof of beneficial effects. Investigations have not yet shown that hypertriglyceridemia is an independent risk factor of CHD. However, these studies did not fully address the potential risk of hypertriglyceridemia because triglyceride levels ranged from 200 to 300 mg/dl in most subjects. Therefore, it is prudent to initiate treatment when serum triglyceride levels exceed 300 mg/dl. High-density lipoprotein (HDL) protects
New develpments in civil commitment of the mentally ill. Impact for patient, family, and psychiatrist
Authors: P. W. Williams
Journal: JAMA (1979)

In deciding<i>Addington vs Texas</i>the US Supreme Court established "clear and convincing evidence" as the standard of proof necessary for civil commitment of the mentally ill rather than the criminal standard, "beyond a reasonable doubt." This decision has major implications for the mentally ill person, the family, and the psychiatrist. The mentally ill person is returned to the role of patient. The family is given aid in their dilemma of coping with their psychotic member. The psychiatrist is seen as helper rather than jailer. (<i>JAMA</i>242:2307-2309, 1979)
Congress moving to improve FDA performance
Authors: C. Marwick
Journal: JAMA (1996)

AFTER MONTHS of talk about shortcomings in the way the Food and Drug Administration (FDA) goes about its job, Congress is finally moving toward developing comprehensive legislation that will, it is hoped, improve the agency's performance. Sen Nancy Kassebaum (R, Kan), chair of the Labor and Human Resources Committee, is holding congressional hearings on legislation she introduced in December. On the House side, Thomas J. Bliley, Jr (R, Va), chair of the Commerce Committee, has promised that he too will hold hearings on legislation that he proposes to introduce. Bliley has been a severe critic of the agency. Although not all will agree that Kassebaum's bill is the perfect solution to resolving the problems that many say plague the FDA and regardless of the outcome, her bill has substantially moved the debate about the agency's performance from charges and countercharges to a serious effort at reform. The US Congress has
Bronchiolitis and bronchitis in connective tissue disease. A possible relationship to the use of penicillamine
Authors: G. R. Epler
Journal: JAMA (1979)

Rapid onset of severe and irreversible airflow obstruction developed in two women. One had eosinophilic fasciitis and the other had rheumatoid arthritis. Both were treated with penicillamine. In the first patient, aged 42 years, dyspnea developed after six months of therapy. Her roentgenogram showed hyperinflation. Forced vital capacity expired in one second (FEV<sub>1</sub>/FVC%) decreased from 75% to 40%, and the residual volume increased by 1 L. In the second patient, aged 54 years, cough and dyspnea developed after ten months of therapy. The FEV<sub>1</sub>/FVC% was 56%, the FEV<sub>1</sub>was 0.9 L, and the roentgenogram was normal. Lung biopsy specimens demonstrated severe and widespread bronchiolitis. An association between obliterative bronchiolitis and rheumatoid arthritis has been reported. Penicillamine may impair healing of bronchiolitis in such patients. (<i>JAMA</i>242:528-532, 1979)
Serum Lipids, Lipoproteins, and Risk of Breast Cancer: A Nested Case-Control Study Using Multiple Time Points
Authors: L. J. Martin, O. Melnichouk, E. Huszti, P. W. Connelly, C. V. Greenberg, S. Minkin, N. F. Boyd
Journal: JNCI Journal of the National Cancer Institute (2015)

Background:There is strong evidence that breast cancer risk is influenced by environmental factors. Blood lipid and lipoprotein levels are also influenced by environmental factors and are associated with some breast cancer risk factors. We examined whether serial measures of serum lipids and lipoproteins were associated with breast cancer risk.
Inhibition of Human Platelet Phospholipase A 2 by Mono(2-Ethylhexyl)phthalate
Authors: Rosalind S. Labow, Erin Meek, George A. Adams, Gail Rock
Journal: Environmental Health Perspectives (1988)

There is evidence that the carcinogenic and teratogenic effects attributed to the plasticizer di(2- ethylhexyl)phthalate (DEHP) are due to its major metabolite mono(2-ethylhexyl)phthalate (MEHP).MEHP is also formed ex vivo by a plasma enzyme in blood products stored in polvinyl chloride (PVC) DEHP plastic containers.People who receive large amounts of blood products, such as hemophiliacs or patients undergoing hemodialysis, cardiopulmonary bypass, or massive transfusion, are exposed to significant levels of plasticizer.In this study, the platelet was used to show that MEHP inhibits phospholipase A2 (PIA2), one of enzymes important in the release of arachidonic acid from membrane phospholipids.Arachidonate is the parent molecule for the synthesis of prostaglandins, thromboxanes, leukotrienes, and lipoxins that are made by a wide variety of cells.PIA2 was measured by the liberation of 14C-arachidonic acid from 1-stearoyl-2-[1-14Clarachidonyl-L-3-phosphatidylcholine.MEHP inhibits PIA2 activity noncompetitively in intact human platelets and lysates with a K; of 3.7 x 104 M. DEHP does not inhibit PIA2 in whole platelets.Inhibition of PLA2 by MEHP occurs at only three times the circulating level of MEHP measured in neonates undergoing exchange transfusion and 20-fold the levels experienced by patients during cardiopulmonary bypass.Therefore, infants and adult patients with multisystem failure who accumulate MEHP in their blood may be at risk for decreased platelet function.
Abstract 7: Mild Therapeutic Hypothermia Using Extracorporeal Cooling Method In Comatose Survivors After Out-Of-Hospital Cardiac Arrest
Authors: Taketomo Soga, Ken Nagao, Kimio Kikushima, Kazuhiro Watanabe, Eizo Tachibana, Takeo Mukoyama, Yoshiteru Tominaga, Katushige Tada, Nobutaka Chiba, Mituru Ishii, Asuka Kasai
Journal: Circulation (2006)

BACKGROUND Although therapeutic hypothermia using external cooling methods can improve the chance of neurological recovery, the neurological benefit is limited to about a half of unconscious adult patients with return of spontaneous circulation (ROSC) after out-of-hospital ventricular fibrillation (VF). We conducted a prospective preliminary study of therapeutic mild hypothermia using extracorporeal cooling methods, and compared the outcome of this study with that of patients treated with normothermia from the SOS-KANTO study. METHODS The criteria for entry these studies was the same as the European hypothermia study ( N. Engl. J. Med 2002 ; 346 : 549 –56 ), except initial cardiac rhythm. The protocol of the hypothermia was as follows: Core temperature was monitored by the bladder temperature until a pulmonary-artery catheter was placed. Intravenous infusion of 1,500~2,000ml of extracellular fluid at 4 degrees centigrade over 30 minutes was immediately initiated after emergency room arrival.Subsequently, patients were cooled to a target temperature of 34 degrees centigrade with the use of an extracorporeal cooling device (KTEK-3, Kawasumi-Co, JAPAN) within 2 hours after the ROSC, and this temperature was maintained precisely for 24 hours when collapse-to-ROSC interval was within 20 minutes, 48 hours when that interval was 20 to 30 minutes, and 72 hours when that interval was more than 30 minutes. The primary endpoint was a favorable neurological outcome at the time of hospital discharge. RESULTS A total of 566 patients were enrolled; 30 were treated with the hypothermia and 539 were treated with the normothermia. Among patients with VF/VT as an initial cardiac rhythm, 17 of the 22 (77.3%) patients in the hypothermia group had a favorable neurological outcome, as compared with 80 of 207 (38.6%) patients in the normothermia group (p&lt;0.001). In addition among patients with PEA or asystole, the hypothermia group was associated with an improvement of a favorable neurological outcome compared with the normothermia group (25% vs 7%, p=0.05). CONCLUSIONS Extracorporeal cooling method may be a preferable approach to mild therapeutic hypothermia in comatose survivors after out-of-hospital cardiac arrest with either VF/VT or PEA/asystole.
Multiple cardiovascular injuries and motor vehicle accidents
Authors: R. K. Primm
Journal: JAMA (1979)

A patient sustained blunt chest trauma in a motor vehicle accident. Cardiovascular trauma was initially obscured by more obvious orthopedic injuries. Thoracic aortic transection with false aneurysm formation was discovered incidentally during cardiac catheterization for traumatic tricuspid insufficiency. Successful repair of both lesions was subsequently performed. This case demonstrates the difficulty in recognizing cardiovascular trauma in survivors of motor vehicle accidents and emphasizes the need for an aggressive diagnostic approach with consideration of coexisting injuries in patients who have sustained blunt chest trauma. (<i>JAMA</i>241:2540-2541, 1979)
Prazosin-new hypertensive agent. A double-blind crossover study in the treatment of hypertension
Authors: A. Schirger
Journal: JAMA (1977)

Prazosin hydrochloride, a new antihypertensive agent, is said to be of mild-to-moderate potency when used as a sole agent in mild-to-moderate hypertension and when used in conjunction with other agents in severe hypertension. In our study of 14 patients comparing hydrochlorothiazide with prazosin, the antigypertensive effect of prazosin was less than that of hydrochlorothiazide. The greatest application of prazosin may be in conjunction with thiazide diuretics and beta-adrenergic blocking agents as the second or third drug.
Inherited predisposition to MDS/AML
Authors: Ana Rio Machin, Kiran Tawana, Jude Fitzgibbon
Journal: HemaSphere (2018)

1Barts Cancer Institute Queen Mary University of London 2Department of Haematology, Addenbrooke's Hospital, Cambridge, UK This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Unusual cause of nonopacification of the gallbladder during oral cholecystography
Authors: R. F. Rosenberg
Journal: JAMA (1980)

<h3>History</h3> An 88-year-old woman was admitted to the hospital because of a 27-kg weight loss during a one-year period and pain in the right upper quadrant and epigastrium. She denied dysphagia, vomiting, or melena. She complained of easy fatigability and malaise and had hypochromic normocytic anemia. A two-day oral cholecystogram resulted in nonvisualization of the gallbladder. On the second day, a chest roentgenogram was obtained and an upper gastrointestinal (GI) tract series was performed (Fig 1 and 2). <h3>Diagnosis</h3> Esophageal carcinoma causing total obstruction of the esophagus. <h3>Comment</h3> The arrows in Fig 1 point to the iopanoic acid tablets that are trapped in the esophagus. Figure 2 shows total obstruction of the midesophagus by a carcinoma. Note the excessive secretions and contrast material above the lesion. As a result of the obstruction, the iopanoic acid tablets never reached the small intestine to be broken down and then conjugated by the