tbuckley/cabot-search huggingface dataset:
Chronic Bronchitis
Authors: Sanford Chodosh, Maurice S. Segal
Journal: New England Journal of Medicine (1964)

Antimicrobial MeasuresThe treatment of bacterial infection of the bronchial tree is the single most important aspect of therapy. The role of bacterial infection in chronic bronchitis is not clear. However, there can be little question that it is almost invariably present to some degree in established chronic bronchitis. Repeated acute infectious episodes are chiefly responsible for the progressive type of disease. The principal organisms incriminated are Haemophilus influenzae and Diplococcus pneumoniae. A high incidence of Staphylococcus aureus in sputum cultures of patients with chronic bronchitis have been observed during epidemic periods such as that of Asian influenza in . . .
Organizations Offering Physician Service Opportunities Overseas
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neumologia y Cirugia de Torax, Mexico
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for Lung Cancer
Authors: Thomas L. Petty
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 October 1989Screening for Lung CancerThomas L. Petty, MDThomas L. Petty, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-7-620_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The excellent review on screening for lung cancer (1) in a recent issue recommends against the use of serial chest roentgenograms or sputum cytology for the early detection of lung cancer. This advice is based upon a thorough review of screening studies, both in this country and in Europe.It might still be wise to pursue early detection in populations with higher risks than those related to smoking and age alone. Good evidence now indicates that there is a common familial component linking lung cancer and obstructive pulmonary disease (2, 3). Recent studies show that a lung...References1. Eddy D. Screening for lung cancer. Ann Intern Med. 1989;111:232-7. LinkGoogle Scholar2. CohenGravesLevy BCD. A common familial component in lung cancer and chronic obstructive pulmonary disease. Lancet. 1977;2:523-6. CrossrefMedlineGoogle Scholar3. Cohen B. Is pulmonary dysfunction the common denominator for the multiple effects of cigarette smoking?. Lancet. 1978;2:1024-7. CrossrefMedlineGoogle Scholar4. SkillrudOffordMiller DKR. Higher risk of lung cancer in chronic obstructive pulmonary disease. Ann Intern Med. 1986;105:502-7. LinkGoogle Scholar5. TockmanAnthonisenWright MNE. Airways obstruction and the risk of lung cancer. Ann Intern Med. 1987;106:512-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PSL Center for Health Sciences Education University of Colorado School of Medicine Denver, CO 80218 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1989Volume 111, Issue 7Page: 620-621KeywordsCancer screeningCell biologyLung and intrathoracic tumorsLungsPopulation statisticsPulmonary diseasesSputumThorax Issue Published: 1 October 1989 PDF DownloadLoading ...
Aphasia in Children.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Worried Sick
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 931: The T790M mutation is acquired through 5-methylcytosine deamination after EGFR TKI treatment in lung cancer
Authors: Najwa El Kadi, Luo Wang, April Davis, Alexander Cooke, Varun Vadnala, Hasan Korkaya, Gregory P. Kalemkerian, Khaled A. Hassan
Journal: Cancer Research (2019)

Abstract Background: Epidermal growth factor receptor (EGFR) activation mutations occur in 10-50% of lung adenocarcinomas. EGFR tyrosine kinase inhibitors (TKIs) are the mainstay of treatment for stage IV non-small cell lung cancer (NSCLC) patients with EGFR mutations. However, acquired EGFR mutations are the main mechanism of on-target resistance to TKIs. T790M mutation that occurs after first generation TKI treatment, is a cytosine to thymine (C&amp;gt;T) single nucleotide transition leading to a threonine to methionine amino acid change at position 790 (i.e. T790M). Our data suggest that resistant mutations are acquired events secondary to cytosine deamination through Activation Induced Cytosine Deamination enzyme (AICDA). Interestingly, treatment with Osimertinib, that overcomes the T790M mutation, leads to other acquired resistant mutations (C797S, G796S/R and L792F/H) that are mostly cytosine based. Results: Sub clones of the lung adenocarcinoma cell line PC9 with no evidence of T790M mutation by digital droplet PCR (ddPCR) at baseline, were treated with EGFR TKI. After serially increasing the treatment dose, T790M mutation was detected by ddPCR associated with a significant increase in AICDA expression. Similarly, when the resistant T790M PC9 clones were treated with Osimertinib, the expression of AICDA was also induced. Knocking down AICDA by shRNA or CRISPR-Cas9, decreases the development of T790M in PC9 cell lines after TKI exposure. Using mass spectrometry, we established that cytosine at codon 790 is methylated; thus, deamination of 5-methylcytosine leads to thymine directly, explaining the T790M C&amp;gt;T mutation. In addition, using ChIP assay and pharmacological inhibition we confirm that upon TKI exposure, NFκB binds AICDA promoter and induces its expression. In a mouse xenograft model, the induction of NFκB and AICDA after EGFR TKI exposure is abrogated by concurrent use of an NFκB inhibitor. Finally, patients treated with EFR TKI had an increased expression of AICDA upon progression. Conclusion: In EGFR driven lung adenocarcinoma, NFκB pathway is activated upon exposure to EGFR TKIs which induces AICDA expression. AICDA deaminates cytosine into other nucleotides leading to treatment resistance. Citation Format: Najwa El Kadi, Luo Wang, April Davis, Alexander Cooke, Varun Vadnala, Hasan Korkaya, Gregory P. Kalemkerian, Khaled A. Hassan. The T790M mutation is acquired through 5-methylcytosine deamination after EGFR TKI treatment in lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 931.
Colposcopy Rates Reported Incorrectly
Authors: Stephen Hampton, Randel Swanson, Douglas Smith
Journal: JAMA (2018)

means (below 10th percentile relative to their average performance).This meets standard criteria for neuropsychological impairment and was the justification for our clinical determination of domains of cognitive weakness.In an attempt to be comprehensive in describing deficits, we did not have space in a single report to provide sufficient detail about each relevant clinical and research domain.For example, audiologic evaluations beyond pure tone audiometry, such as suggested by Dr Gianoli and colleagues, were conducted but omitted.Based on these unpublished findings and expertise of our colleagues in audiology and otorhinolaryngology, there were not clinical indications of unilateral or bilateral labyrinthine injury.To further address these discussions, we are performing advanced neuroimaging studies of the patient cohort, hoping to identify structural brain changes that may underlie the neurological manifestations.
Touching: The Human Significance of the Skin
Authors: Philip C. Anderson
Journal: JAMA (1987)

Science fiction need not be only about alien worlds, HAL-series guidance systems, and starships, but may also focus on such commonplace subjects as the skin. If we wish to understand certain odd but popular schools of sociology and anthropology, it is best to recognize them as commercial journalism, dressed up, like Ashley Montagu's<i>Touching</i>, in new titles and presumptions. Montagu, distinguished as a teacher and successful as an author (more than 60 books), has produced many works that typify this colorful trade. As is usual in commercial journalism, the emphasis is on intellectual tricks and quick charm, rather than precise exposition, so we read about the skin as the "largest organ," "neglected," and "a tissue of human contact." We learn of "the thumb as a substitute for mother" or "sex as a language" (?) and focus far too much on the presumed worldview of monkeys. We consider the "centrifugal approach" and
The weight of evidence
Authors: L. Tushnet
Journal: JAMA (1970)

My lords, the happenings of this case are, to wit: Robert the Surgeon, of Friday Street, rented a house and tavern to one Symon, in St. Martin's parish, there to conduct his trade. Said Symon had a servant, Roger from Westminster, who, in the night following St. Nicholas's Day, December sixth, in the fifth year of King Edward, 1277, did most foully murder his master. And the manner of the murder was thus: Roger cut the throat of the said Symon, asleep in his bed, and did cut off the head entirely from the body, after which he dragged the body to a dark and secret place, a bin between two walls in the house, wherein coals were wont to be kept, such place being long, and not quite two feet wide. The next day, dissembling, the said Roger did put out the bench in front of the tavern and
Incorrect Wording in News From the Food and Drug Administration
Authors: Claude Matuchansky
Journal: JAMA (2016)

the second and third parts of the duodenum only. 2 Thus, the 10-cm proximal duodenal segment explored by the authors, while probably including the periampullary area, did not examine and may not have been representative of those more distal areas predominantly involved by adenomas in FAP, a limitation not discussed by the authors.Second, in their endoscopic assessment of duodenal neoplasia burden, the authors did not state whether they also detected flat adenomas within the study segments in their patients.Besides polypoid neoplasias, flat adenomas can be found in the duodenum of approximately 30% of patients with FAP, and careful follow-up of these patients has been recommended. 4,5It would be of interest to know more about these lesions in their study.
Acute lymphocytic leukemia in children: maintenance therapy with methotrexat administered intermittently. Acute Leukemia Group B
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The influence of TRPM8 variant on brown adipose tissue activity and contribution to increased susceptibility to non-alcoholic fatty liver disease among South Asians
Authors: Jane Chalmers, Declan Wayne, Jane Grove, Michael Symonds, Helen Budge, Harold Sacks, Leena Mohan, KT Shenoy, Guruprasad Aithal
Journal: Journal of Hepatology (2020)
Somatization
Authors: Richard Mayou
Journal: Psychotherapy and Psychosomatics (1993)

Medically unexplained symptoms are common in the general population and in all medical settings. Although often transient, a sizeable proportion are persistent and associated with considerable effects on quality of life. Aetiology is often multi-causal, and associated psychiatric disorder is frequently, but not invariably, present. General principles of treatment and specialist procedures are reviewed.
Glaucoma
Authors: A. King, A. Azuara-Blanco, A. Tuulonen
Journal: BMJ (2013)

<h3>BACKGROUND:</h3> Radiotherapy for breast cancer has been implicated in the development of bronchiolitis obliterans organizing pneumonia (BOOP). Patients may be asymptomatic or may have pulmonary and constitutional symptoms that are moderate or severe. Postradiotherapy BOOP usually develops during the 12&nbsp;months after completion of radiotherapy and is characterized by ground-glass opacities in the radiation-exposed lung and frequently in the non-irradiated lung. <h3>METHODS:</h3> An updated literature search and review was performed to update the systematic review we conducted in 2014. Ten new publications were identified: 2 Japanese epidemiological studies, 1 Japanese case series study, 6 case reports, and 1 review article. <h3>RESULTS:</h3> The incidence of postradiotherapy BOOP was 1.4% in both Japanese epidemiological studies. Risk factors included increasing age, cigarette smoking, and increasing central lung distance. The case reports included 7 women who had breast cancer postradiation BOOP and 1 woman who had an ataxia telangiectasia mutated (<i>ATM</i>) gene mutation, which may increase radiation sensitivity. <h3>CONCLUSION:</h3> Postradiotherapy BOOP in women with breast cancer occurs at a rate of 1.0–3.0% and may occur in women with immune system dysfunction and genetic mutations.
Highlights
Authors: S Kuhn, K Desai
Journal: JAMA Internal Medicine (2015)

The Mini-Mental State Examination (MMSE) is the proprietary instrument for dementia screening.Tsoi and colleagues performed a meta-analysis on 149 diagnostic studies with over 49 000 subjects to compare the diagnostic accuracy between the MMSE and 10 other screening tests.Results showed screening tests other than the MMSE were comparably eff ective, easier to perform, and available for little or no cost.These fi ndings support the increasing use of other tests for dementia screening.
Low Back and Sciatic Pain Caused by Intervertebral Disc Herniation: Anatomic and Clinical Investigations
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Four-Year Follow-up of the Phase 3 Pollux Study of Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) Alone in Relapsed or Refractory Multiple Myeloma (RRMM)
Authors: Jonathan L. Kaufman, Saad Z. Usmani, Jesús San-Miguel, Nizar Bahlis, Darrell J White, Lotfi Benboubker, Gordon Cook, Merav Leiba, P Joy Ho, Kihyun Kim, Naoki Takezako, Philippe Moreau, Maria Krevvata, Huiling Pei, Jon Ukropec, Thomas Renaud, Sonali Trivedi, Rachel Kobos, Meletios A. Dimopoulos
Journal: Blood (2019)
RELATIONSHIP BETWEEN STRUCTURE OF BENZIMIDAZOLE DERIVATIVES AND SELECTIVE VIRUS INHIBITORY ACTIVITY
Authors: Igor Tamm, Rostom Bablanian, Marjorie M. Nemes, Clifford H. Shunk, Franklin M. Robinson, Karl Folkers
Journal: The Journal of Experimental Medicine (1961)

On page 628, some of the structural formulas within Table I appear in heavy type. This effect is due to defective cuts and has no scientific significance.
Celiac Sprue
Authors: J S Trier
Journal: New England Journal of Medicine (1991)

OVER a century ago, in a classic paper, Samuel Gee1 provided a thorough description of the clinical features of childhood celiac sprue. However, subsequent truly seminal observations regarding celiac sprue awaited the 15 years that followed World War II. During that period, Dicke,2 a Dutch pediatrician, astutely observed that the ingestion of certain cereal grains, including wheat and rye, were harmful to children with this disease and then demonstrated, with van de Kamer and Weijers, that the alcohol-soluble, or gliadin, component of the water-insoluble protein, or gluten, moiety of wheat produced fat malabsorption in patients with celiac sprue.3 , 4 A few . . .
Abstract P127: Posttraumatic Stress Disorder and Risk for Coronary Heart Disease: A Meta-analytic Review
Authors: Donald Edmondson, Ian M Kronish, Jonathan A Shaffer, Louise Falzon, Matthew M Burg
Journal: Circulation (2013)

Context: Recent evidence suggests that posttraumatic stress disorder (PTSD) may be associated with increased risk for coronary heart disease (CHD). Objective: To determine the association of PTSD to incident CHD using systematic review and meta-analysis. Data Sources: Articles were identified by searching Ovid MEDLINE, PsycINFO, Scopus, Cochrane Library, PILOTS database, and through manual search of reference lists. Study Selection: Prospective cohort studies that assessed PTSD in participants free of CHD and assessed subsequent CHD or cardiac-specific mortality. Data Extraction: We extracted estimates of the association of PTSD to incident CHD, as well as study characteristics. Odds ratios were converted to hazard ratios (HR), and a random-effects model was used to pool results. Data Synthesis: Five studies met our inclusion criteria (N= 401,712); 4 of these included depression as a covariate. The pooled HR for the magnitude of the relationship between PTSD and CHD was 1.53 (95% CI, 1.27-1.84) before adjustment for depression. The pooled HR estimate for the 4 depression-adjusted estimates (N= 362,388) was 1.22 (95% CI, 1.05-1.42). Conclusion: PTSD is independently associated with increased risk for incident CHD, even after adjusting for depression and other covariates. Figure 1. Forest plot of association of PTSD to incident MI or cardiac mortality Note: The area of each square is proportional to the study’s weight in the meta-analysis, and each line represents the confidence interval around the estimate. The diamond represents the aggregate estimate, and its lateral points indicate confidence intervals for this estimate.