tbuckley/cabot-search huggingface dataset:
Use of patient-reported outcome measures in Quality Oncology Practice Initiative registered practices: Results of a national survey.
Authors: Biqi Zhang, Whitney Lloyd, Mohammad Jahanzeb, Michael J. Hassett
Journal: Journal of Clinical Oncology (2016)

e18236 Background: Measuring patient-reported outcomes (PROs) improves the experience of care and reduces the burden of disease for cancer patients. Professional societies, including ASCO, encourage the collection of PROs, but little is known about how many practices collect PROs and, if so, which PROs are measured and what challenges are met in implementation. Methods: We surveyed Quality Oncology Practice Initiative (QOPI) registered practices to understand the current state of PROs use and identify areas where greater support for PROs implementation may be needed. One respondent from each practice was invited to complete an online survey. PROs users were asked to describe their views regarding PROs and to identify challenges with implementation. Non-users were asked about their interest in and barriers to future collection of PROs. Results: Of 233 practices that viewed the request to participate, 109 completed the survey (47%). Most responding practices (73%) currently collect PROs. Of these, 79% are affiliated with hospitals/medical centers, 50% have > 10 advanced practice providers, and 94% use electronic health records. PROs users see more patients/week than non-users (p < 0.01). Practices collect a wide variety of PROs, including validated and home-grown questionnaires. The most commonly measured PROs are distress (78%), symptom assessment (76%), and experience/satisfaction (70%). The most frequently reported implementation challenges were the same for users and non-users: patient unwillingness to complete questionnaires (34%) and insufficient staff to support collection (29%). Despite only moderate perceived patient willingness to answer PROs (2.67/5), 79% of all practices believe collecting PROs is a high priority. Conclusions: While many QOPI practices have implemented PROs, substantial barriers to implementation are apparent and may be limiting more wide-spread adoption. Efforts to identify which PROs most improve care quality are sorely needed. Sharing best practices on improving patient/provider buy-in and enabling efficient integration of PROs into clinic workflow may also facilitate adoption and maximize the utility of PROs for oncology practices.
Ohio State Medical Society.
Journal: JAMA (1884)

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Chemistry Nobel Honors CRISPR, an “Essential” Tool for Cancer
Journal: Cancer Discovery (2020)

Abstract Emmanuelle Charpentier, PhD, and Jennifer Doudna, PhD, who pioneered the site-specific CRISPR gene-editing technology that has revolutionized cancer research and treatment, were awarded the 2020 Nobel Prize in Chemistry. Many CRISPR-based therapies are already in human testing, with gene-edited T cells for blood cancers and solid tumors leading the way.
Atlas of Diseases of the Skin: With Diagnostic and Therapeutic
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spray Adhesives and Birth Defects
Authors: Godfrey P. Oakley
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In August 1973, spray adhesives were removed from the market in the United States because of concern that they might be mutagenic or cause birth defects or both.<sup>1</sup>With the cooperation of several geneticists and public health persons, we registered 41 families that had sought reproductive counseling because of a current pregnancy and because of exposure to spray adhesives prior to conception or during the first trimester or both. Of these 41 families, three were lost to follow-up, and there was no pregnancy in two families. From the remaining 36 pregnancies, 33 infants were born without birth defects, two infants were born with birth defects, and one fetus was aborted spontaneously. One of the infants with birth defects had a clubfoot, and the other died in the neonatal period from congenital heart disease. The outcome of this small cohort of pregnancies suggests no unusual occurrence of
THE CATALASE CONTENT OF THE CEREBROSPINAL FLUID
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatric Inpatients at a Teaching Hospital
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of a new antibiotic. Sodium cephalothin (Keflin)
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unemployment Insurance: A Summary of Some Existing Governmental and Private Plans
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The medical student externship. The viewpoint of the medical educator
Authors: J. L. Caughey
Journal: JAMA (1970)

As far as I know, medical educators have been most concerned about clinical externships engaged in by medical students during regular school terms. The<i>traditional</i>view of the medical educator about such clinical externships for medical students has been quite clear. The medical school faculty knows what is best for the medical student and has designed the best possible sequence of experiences to facilitate his learning in a logical and sensible way. It is disruptive when a student deviates from the prescribed program because he may learn something too early and not pay attention to more elementary things presented to him later in the regular curriculum of his school. There is the distinct possibility that a student trying to learn something outside the pure environment of the university medical center will run into some kind of sinister environmental pollution which will partially paralyze his intellectual and ethical
Culyer reforms will create new opportunities for research
Journal: BMJ (1998)

How the cycle of poverty and ill health can be brokenEditor-To paraphrase a well known remark-wars are too serious to be entrusted to generals-public health, especially among poor people in developing countries and in the inner cities of industrialised countries, is too serious to be left to doctors and nurses alone.We say this quite deliberately as medical doctors on the staff of the World Health Organisation, of the Maryland department of health and mental hygiene, of universities, and of non-governmental organisations in Britain, Colombia, and Kenya.Our conviction is based on many years of work in the field in Africa, Asia, and Latin America, as well as in inner cities of the developed countries of Europe and North America.The number one health problem is poverty.For the poorest countries, the health sector alone cannot ensure better health even if it were able to function at maximum effectiveness.We have to accept that we can no longer deal with health while ignoring poverty.
Geriatric Medicine
Authors: Karen M. Prestwood
Journal: JAMA (1992)

Stroke is a major cause of morbidity and mortality in older men and women, and advanced age is the most consistent risk factor for all types of stroke.<sup>1</sup>Recent controlled studies evaluating the treatment of two major risk factors for stroke, isolated systolic hypertension (ISH) and nonvalvular atrial fibrillation, have shown considerable benefit in reducing stroke rate, even in the oldest age groups. Defined as systolic blood pressure greater than 160 mm Hg and diastolic blood pressure less than 90 mm Hg, ISH increases with age secondary to a decrease in arterial compliance.<sup>2</sup>The risks of cardiovascular and cerebrovascular events are increased with ISH; for any given systolic blood pressure, the oldest age groups have the highest number of events.<sup>3,4</sup> The Systolic Hypertension in the Elderly Program was initiated to examine the effectiveness of ISH treatment in persons older than 60 years.<sup>5</sup>Just less than 5000
Extension of the Raccoon Rabies Epizootic—1992
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I/II study of AT-101 in combination with topotecan in patients with relapsed or refractory small cell lung cancer after prior platinum containing first line chemotherapy
Authors: R. S. Heist, J. R. Molina, W. J. Urba, H. Mirshahidi, S. Grunberg, J. Maleski, V. Brainerd, L. Leopold, T. J. Lynch
Journal: Journal of Clinical Oncology (2008)

19004
Cytoprotection by fructose and other ketohexoses during bile salt-induced apoptosis of hepatocytes
Authors: I Zeid
Journal: Hepatology (1997)

Toxic bile salts cause hepatocyte necrosis at high concentrations and apoptosis at lower concentrations. Although fructose prevents bile salt- induced necrosis, the effect of fructose on bile salt-induced apoptosis is unclear. Our aim was to determine if fructose also protects against bile salt-induced apoptosis. Fructose inhibited glycochenodeoxycholate (GCDC)-induced apoptosis in a concentration-dependent manner with a maximum inhibition of 72% ± 10% at 10 mmol/L. First, we determined if fructose inhibited apoptosis by decreasing adenosine triphosphate (ATP) and intracellular pH (pHi). Although fructose decreased ATP to <25% of basal values, oligomycin (an ATP synthase inhibitor) did not inhibit apoptosis despite decreasing ATP to similar values. Fructose (10 mmol/L) decreased intracellular pH (pHi) by 0.2 U. However, extracellular acidification (pH 6.8), which decreased hepatocyte pHi 0.35 U and is known to inhibit necrosis, actually potentiated apoptosis 1.6-fold. Fructose cytoprotection also could not be explained by induction of bcl-2 transcription or metal chelation. Because we could not attribute fructose cytoprotection to metabolic effects, alterations in the expression of bcl-2, or metal chelation, we next determined if the poorly metabolized ketohexoses, tagatose and sorbose, also inhibited apoptosis; unexpectedly, both ketohexoses inhibited apoptosis. Because bile salt-induced apoptosis and necrosis are inhibited by fructose, these data suggest that similar processes initiate bile salt-induced hepatocyte necrosis and apoptosis. In contrast, acidosis, which inhibits necrosis, potentiates apoptosis. Thus, ketohexose-sensitive pathways appear to initiate both bile salt-induced cell apoptosis and necrosis, whereas dissimilar, pH-sensitive, effector mechanisms execute these two different cell death processes.
Architectural aids for the disabled.
Journal: BMJ (1967)

Allergic GastroenteropathyThe combination of oedema of obscure origin, hypoalbuminaemia, and gastrointestinal disturbance suggests the possibility of exudative enteropathy or protein-losing gastroenteropathy.This syndrome may be associated with giant hypertrophy of the gastric rugae,1 regional ileitis and ulcerative colitis,2 sprue,3 intestinal lipodystrophy,4 gastric carcinoma," intestinal lymphangiectasia,' constrictive peri- carditis and congenital atrial septal defect," neonatal steatorrhea with small-bowel dysfunction," and hypoganimaglobulinaemia.' To this growing list of causes of protein- losing gastroenteropathy may now be added a group of six young children with oedema, extreme hypoproteinaemia,
Notices
Authors: Jules Frcp, Anil Dhawan, Frcpch For, Lucia Debiase, Andres Blei, H Blum, Geoff Farell, Ed Gane, Norio Hayashi, P Kamath, S Lam, George Lau, Nancy Leung, Y Liaw, Stephen Locarnini, Anna Lok, M Omata, John Rodes, Jose Sollano, Arun Sanyal
Journal: Hepatology (2003)

This unique course will provide state-of-the-art lectures, tutorials, and case discussions to facillitate the optimal management of liver disease in both children and adults.The focus of the course is to empower clinicians and health professionals to undertake effective clinical practice from evidence-based perspective.There will be parallel sessions on subjects that are of exclusive interest to pediatricians, physicians, and surgeons.Topics will include Applied Anatomy, Physiology, Molecular Biology of the Liver,
Abstract 5455: A Novel Haplotype on GCH1 Gene, Encoding GTP Cyclohydrolase 1, Regulates Vascular Biopterin Synthesis, eNOS Coupling and Vascular Redox in Human Vessels
Authors: Charalambos Antoniades, Cheerag Shirodaria, Thomasz Guzik, Tim Van-Assche, Ravi Pillai, Jorn Lotsch, Dimitris Tousoulis, Christodoulos Stefanadis, Irmgard Tegeder, Keith M Channon
Journal: Circulation (2008)

Background: GTP cyclohydrolase (GTPCH) is a key enzyme in biopterins synthesis, while tetrahydrobiopterin (BH4) is a regulator of eNOS coupling in vascular endothelium. A novel haplotype in GCH1 gene, combining dbSNPs: rs8007267G/A, rs3783641A/T and rs10483639C/G, affects GTPCH activity and biopterins levels in inflammatory cells. We examined the effect of this haplotype on vascular biopterins, eNOS coupling and redox state in human vessels from patients with coronary atherosclerosis. Methods: Samples of saphenous veins (SV) were obtained from 347 patients undergoing CABG. Vasorelaxations of SV to acetylcholine (ACh) and vascular O2- (± eNOS inhibitor LNAME) were determined. Biopterins were measured by HPLC. The haplotypes were defined as X (rs8007267A+ rs3783641T+ rs10483639G) or O (all other haplotypes). Results: The haplotype distribution was OO:245(71%), OX:95(27%) and XX:7(2%). Carriers of the X haplotype had lower plasma (Fig. a ) and vascular (Fig. b ) BH4. The X haplotype was associated with higher vascular O2- (XX+XO: 2.97±0.44 vs OO:1.90±0.10 RLU/Sec/mg, p&lt;0.01), greater LNAME-inhibitable O2- (Fig. c ) suggesting eNOS uncoupling) and lower NO bioavailability (Fig. d ) in human vessels. The X haplotype was also associated with higher plasma ox-LDL (51.0±2.2 in XX+XO vs 44.2±1.4 U/L in OO p&lt;0.05) and lower BH4:total biopterins ratio (43.1±3.2 in XX+XO vs 51.7±2.1% in OO, p&lt;0.05). Conclusions: This novel haplotype on GCH1 gene regulates biopterins biosynthesis in both plasma and vascular endothelium. This haplotype also regulates eNOS coupling, O2- production and NO bioavailability in human vessels, and may play a role in atherogenesis.
Probiotics: how microorganisms compete
Authors: G. Reid
Journal: JAMA (1996)

<h3>To the Editor.</h3> —I was pleased to see the article on biotherapeutic agents by Dr Elmer and colleagues.<sup>1</sup>The traditional response to microbial attack on a body system is to use antibiotics, but is this option exclusive or even optimal? The advent of antibiotics has strong roots in the recognition that microorganisms can, and do, use their own systems to compete and kill other organisms that vie for their ecological niche. Impressive chemical and genetic manipulations have superseded the extraction of microbial by-products. Indeed, chemical agents have saved countless lives. However, they are not the complete answer, and they will not stem the critical tide of microbial drug resistance.<sup>2</sup> The advent of molecular technologies has provided the tools to better understand the role of these agents in well-being. Using restriction fragment length polymorphism and plasmid profiling, we have shown that the colonization of a surface by an
Book Review
Authors: Klaus Engel, Iris Meier, Rolf Sandell, Karin Barth, Geir Nielsen, Brit Haver, Odd E. Havik, Ester Mølstad, Henrik Rogge, Marit Skåtun, Gabriella Ba, Noomi Lindberg, Erik Lindberg, Mark G. Haviland, Dale G. Shaw, Michael A. Cummings, James P. MacMurray
Journal: Psychotherapy and Psychosomatics (1988)