tbuckley/cabot-search huggingface dataset:
Very-small-nuclear circulating tumor cell (vsnCTC) as a putative biomarker for visceral metastasis (VM) in metastatic castration-resistant prostate cancer (mCRPC).
Authors: Jie-Fu Chen, Hao Ho, Elisabeth Hodara, Shirley Cheng, Alexander Ureno, Ann Go, Margarit Sievert, Leland WK Chung, Hsian-Rong Tseng, Edwin M. Posadas
Journal: Journal of Clinical Oncology (2016)

e16530 Background: Patients with metastatic castration-resistant prostate cancer (mCRPC) with visceral metastasis (VM) have a poorer clinical outcome in comparison to those without VM. As VM are often discovered late in the disease course, their clinical course often culminates in organ failure. There are no existing tests that identify men at risk for VM other than imaging. Our team has identified an association between the presence of very-small-nuclear circulating tumor cells (vsnCTCs, DAPI+/Cytokeratin+/CD45- and nuclear size < 8.5 µm) and VM. We hypothesized that presence of vsnCTC detects the presence of VM and has prognostic value. Methods: We identified mCRPC patients who had progressed through next generation AR therapy such as abiraterone, enzalutamide, or an equivalent drug. Serial blood specimens were used for vsnCTC enumeration using NanoVelcro CTC Assay as previously published. The vsnCTC counts were related to the presence and development of VM (evaluated by radiography) as well as the response to anti-cancer treatment. Results: Blood specimens were identified from 40 patients who met the eligibility criteria; 18/40 patients presented with VM and 22/40 had bone-only disease at their first CTC enumeration. Six out of 25 non-VM patients developed VM during follow-up, and vsnCTCs were detected 86-196 days prior to radiographic detection of VM (true positive); 5/25 had vsnCTCs detected but no VM was found by the time of analysis (false positive). None of the vsnCTC(-) patients developed VM. vsnCTCs were detected in 24/24 (100%) VM patients compared to 5/16 (31%) non-VM patients. Reduction of vsnCTC count occurred at initiation of anti-cancer treatment; transition from vsnCTC(-) to vsnCTC(+) was seen prior to progression under the treatment. Sixteen out of 24 (67%) VM patients passed away, compared to 5/16 (31%) non-VM patients, by the time of analysis. Conclusions: vsnCTC is associated with the presence of VM and is a potential biomarker for predicting the development of VM and monitoring the treatment response in mCRPC. Transition from vsnCTC(-) to vsnCTC(+) was associated with the development of VM and progression under the treatment.
Monitoring resuscitation of the injured patient
Authors: J. M. Hartong
Journal: JAMA (1977)

Physicians are being called on with increasing frequency to initiate resuscitation of the severely injured patient. The medical literature is confusing regarding the best way that this can be done. A study was undertaken to evaluate simultaneously four common, easily measured indexes—blood pressure, pulse rate, central venous pressure, and pulmonary artery pressure. A shock-trauma model employing laboratory-bred beagle dogs was developed. Results indicate that the best single index is pulmonary artery pressure. Certain physiologic principles make central venous pressure an unreliable index. (<i>JAMA</i>237:242-244, 1977)
Serum Levels of Bactericidin and Globulin in Schizophrenia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Training
Authors: Sarah Wakeman
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Extracorporeal high-intensity focused ultrasound for VX2 liver tumors in the rabbit*1
Authors: F PRAT
Journal: Hepatology (1995)

High-Intensity Focused Ultrasound (HIFU) can produce radical tissue necrosis. We wanted to assess tumor destruction, proliferation, and tumorigenesis after HIFU, in an animal model of hepatic tumor. New Zealand rabbits bearing VX-2 solitary liver tumors were treated with extracorporeal HIFU under ultrasound (US) guidance and standardized conditions. Groups differed only for the administration of either one or two consecutive HIFU procedures. Tissue destruction was assessed by stereomicroscopy and planimetry, cell proliferation was estimated by in vivo intra-arterial injection of 1200 μCi [3H]thymidine, and tumorigenesis was tested by reimplantation of treated or untreated pieces of liver tumors into the thighs of nontumor-bearing animals. Mortality was 0. Tumor destruction rates were 76.3% ± 16% after one procedure and 94.2% ± 7.3% after two procedures. Nuclear staining was heavy in control tumors and was absent in treated tumors. Untreated hepatic tumors induced measurable tumors at 3 weeks in thighs of all recipients, 7.8 ± 2.4 cm3 in volume. Hepatic tumors treated with one HIFU procedure induced tumors in the thigh of recipients in 31.3% of cases (0.47 ± 0.06 cm3), and those treated with two HIFU procedures induced tumors in 0% even after 8 weeks of follow-up. In conclusion, HIFU allows a noninvasive approach to the destruction of liver tumors in this model, with little toxicity but significant effects on proliferation and tumorigenesis. The repetition of HIFU procedures may improve results.
The nuclear waste problem: how to dispose of the undisposable?
Authors: B. Merz
Journal: JAMA (1988)

WHAT TO DO with radioactive wastes has become one of the most urgent environmental questions of the age. In recent months, reports of leakage from radioactive dump sites have fingered the Department of Energy (DOE), the US military, and manufacturers of atomic power, both public and private, as nuclear polluters. In early June, Radioactive Waste Campaign, a watchdog group headquartered in New York City, issued an analysis of the problems the DOE has encountered in managing wastes from 19 nuclear-weapons manufacturing plants. It pinpointed violations of state and federal environmental laws dating back four decades, which have produced levels of contamination so high that they may never be cleaned up. The report, unchallenged by the DOE, stated that cleaning up present waste sites would run far in excess of the $100 million the agency had projected. A week later, the House Energy and Commerce Committee's Oversight and Investigations Subcommittee released
Books Received
Authors: Franco Benazzi, Masayo Kojima, Yoshihiro Senda, Teruo Nagaya, Shinkan Tokudome, Gudrun Schneider, Georg Driesch, Andreas Kruse, Michael Wachter, Hans-Georg Nehen, Gereon Heuft, Willeke H. van Zelst, Edwin de Beurs, Aartjan T.F. Beekman, Dorly J.H. Deeg, Richard van Dyck, Peter Tyrer, Tom Sensky, Sarah Mitchard, David Healy, David MacLean, Chiara Rafanelli, Renzo Roncuzzi, Livio Finos, Eliana Tossani, Elena Tomba, Lara Mangelli, Stefano Urbinati, Giuseppe Pinelli, Giovanni A. Fava, Zoltán Rihmer, Franco Benazzi, Angelo Picardi, Mohammad Reza Namazi, Richard Balon, Karina W. Davidson, Paul Rowan, Cheryl Barksdale, Toshiaki A. Furukawa, Michael William MacGregor
Journal: Psychotherapy and Psychosomatics (2003)

This is a very helpful guide to a psychotherapeutic treatment that is getting increasing attention.It gives a very clear account of the various steps of interpersonal psychotherapy.
Diagnostic and therapeutic technology assessment. Radial keratotomy for simple myopia
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obesity-specific health-related quality of life in patients with non-alcoholic steatohepatitis: results from the regenerate study
Authors: Zobair M. Younossi, Maria Stepanova, Fatema Nader, Rohit Loomba, Quentin Anstee, Vlad Ratziu, Stephen Harrison, Arun Sanyal, Jacob George, Susanne Beckebaum, David Orr, Giuseppe Mazzella, Vićtor Manuel Vargas Blasco, Lise Lotte Gluud, Rifaat Safadi, James F. Trotter, Jaideep Behari, David Sheridan, Muhammad Sheikh, Martin Bonacci, Gail Cawkwell, Bruce Wong, Pierre Bedossa, Zachary Goodman, Mary Rinella
Journal: Journal of Hepatology (2020)
Sickle cell disease and trait in white populations
Authors: A. P. Gelpi
Journal: JAMA (1973)

The sickle cell gene is widely distributed among populations of southern Europe, the Middle East, and India, reflecting diffusion of African genetic material during a millennium or more of the east African slave trade. Mild homozygous sickle cell disease, reported among Eti-Turks and Arabs from Kuwait and Saudi Arabia, may in part represent favorable interaction between sickle cell disease and α-thalassemia or hemoglobin H disease. Favorable interaction between glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and sickle cell disease, in populations where high frequencies of the enzyme defect and the sickle cell trait coexist, has been postulated but certainly not established. A better understanding of sickle cell disease may be afforded by further studies of the problem in populations with high frequencies of the thalassemia traits and G-6-PD deficiency occurring in association with sickle cell disease.
Nurses in a crossfire
Authors: D. B. Hiscoe
Journal: JAMA (1970)

The Lansing (Mich) Visiting Nurse Association (VNA) and its Coordinated Home Care Program have been examined, with particular attention paid to the nurse's position and problems within the medical community. It is apparent that these nurses are already functioning as a special type of physician's assistant. Many problems are unresolved, but their role offers important opportunity for increased service in the future.
Multifocal Melorheostosis
Authors: Tim McCay, John Mulvihill, Joe C Leonard
Journal: Clinical Nuclear Medicine (2006)

Sclerosing lesions of bone such as melorheostosis, osteopathia striata, and osteopoikilosis have rather characteristic but overlapping radiographic features with differential bone scan findings. These lesions usually involve a single bone. We present a patient who had radiographic evidence of involvement in at least 2 sites who was shown by bone scintigraphy to have diffuse symmetric involvement of the appendicular skeleton.
A Textbook of Medical Diseases for Nurses Including Nursing Care
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sex determinants in heart disease
Authors: S. Vaisrub
Journal: JAMA (1977)

Sex discrimination in myocardial infarction, which leaves in its wake many more widows than widowers, has yet to be explained. Because this discrimination ceases after the menopause, it was only logical to assume that ovarian hormones exert a protective effect. However, plausible as this assumption may be, it was never proved, nor did it receive support from observations on men who were taking estrogens for reasons unrelated to vascular disease. Their susceptibility to coronary thrombosis has increased, as has the susceptibility to thromboembolism in some women taking estrogenic oral contraceptives. While the role of ovarian hormones in protecting women from coronary heart disease had been awaiting clarification, some investigators turned their attention to another aspect of menarche—the natural "blood letting" of menstruation. Speculating that increased blood viscosity related to a high hematocrit may be a factor in coronary thrombosis, De Pasquale and Burch<sup>1</sup>suggested that the low incidence of
Primary vesicoureteral reflux and end-stage renal disease
Authors: O. Salvatierra
Journal: JAMA (1973)

Eighteen patients with end-stage renal failure secondary to primary bilateral vesicoureteral reflux are presented. These cases document a potential terminal phase in the natural history of vesicoureteral reflux. Five patients had sterile reflux alone, and four patients probably had sterile reflux until urinary tract infection occurred at our near endstage renal failure. The remaining patients had reflux associated with recurring urinary tract infection. Early diagnosis and proper management are important in vesicoureteral reflux.
Getting Religion Seen as Help in Being Well
Authors: M. Mitka
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Appointments at Ohio State University.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology of fulminant hepatitis E cases in Vienna - an informative case series
Authors: David JM Bauer, Stephan Aberle, Anna Farthofer, David Chromy, Benedikt Simbrunner, Dr. Lisa Steininger, Mattias Mandorfer, Ralf Schmidt, Michael Trauner, Robert Strassl, Florian Mayer, Heidemarie Holzmann, Thomas Reiberger
Journal: Journal of Hepatology (2020)
Solving big problems for little people
Authors: Susan Lawrence
Journal: JAMA (1983)

It's been about 20 years since Johns Hopkins geneticist Victor A. McKusick, MD, first addressed an organization known as the Little People of America (LPA) on dwarfism. McKusick's delineation of an autosomal recessive form of short-limbed dwarfism known as cartilage-hair hypoplasia among the Amish population had recently been publicized, and members of LPA were interested in learning about the causes of their short stature. At the time, most physicians knew little about dwarfism. People with short limbs were considered to have achondroplasia; those with trunk abnormalities were thought to suffer from Morquio's syndrome. McKusick's initial contact with the national selfhelp organization formed by short people led to a remarkable, ongoing cooperative effort between the LPA and Johns Hopkins University School of Medicine, Baltimore. As a result, a comprehensive research program sprang up at Hopkins that so far has led to the identification of nearly 100 distinct, heritable genetic conditions that
Let's stop driving after drinking and using other psychoactive drugs
Authors: G. D. Lundberg
Journal: JAMA (1986)

"Ethyl alcohol (alcohol) kills every day in Chicago, Los Angeles, New York, Paris, and virtually every other city in the Western World."1 One of the principal ways in which it kills is by accidents, especially those involving motor vehicles. On Oct 12, 1984, we published an editorial about ethyl alcohol in which we set forth ten proposals. One was that "We as a society should make an abrupt change from our current practice of socially promoting so-called moderate drinking and driving as a norm and should, instead, by policy and example, simply not drive after drinking alcohol at all."<sup>1</sup> It is a source of great satisfaction to publish in this issue a report from the Council of Scientific Affairs<sup>2</sup>of the American Medical Association entitled "Alcohol and the Driver," which was adopted by the AMA at its Annual meeting in Chicago in June 1985, becoming official policy. This
Announcement
Authors: Markus Dold, Siegfried Kasper, Lucie Bartova, Rainer Rupprecht, Yvonne Burnand, Antonio Andreoli, Laura Frambati, Donna Manning, Alessandra Canuto, Allen Frances, André F. Carvalho, Foteini Delis, Nafsika Poulia, Petros Bozidis, Vassiliki Paika, Elisavet Ntountoulaki, Dimitra Papaioannou, Else Guthrie, Katerina Antoniou, Thomas N. Hyphantis, Jessica A. Hartmann, Patrick D. McGorry, Stefanie J. Schmidt, Lieuwe de Haan, Anita Riecher-Rössler, Alison R. Yung, G. Paul Amminger, Hok Pan Yuen, Connie Markulev, Gregor E. Berger, Eric Y.H. Chen, Ian B. Hickie, Suzie Lavoie, Meredith J. McHugh, Nilufar Mossaheb, Dorien H. Nieman, Merete Nordentoft, Miriam R. Schäfer, Monika Schlögelhofer, Stefan Smesny, Andrew Thompson, Swapna Kamal Verma, Barnaby Nelson, Jeffrey R. Vittengl, Maurizio Fava, Christopher E.M. Griffiths, Andrew H. Miller, James Russell, Susan G. Ball, Wen Xu, Nayan Acharya, Mark Hyman Rapaport, Giovanni A. Fava, Giovanni A. Fava, Nicoletta Sonino, Ralph I. Horwitz, Burton H. Singer, Allison Hayes-Conroy, Enrico Premi, Silvia Compostella, Barbara Borroni, Alberto Benussi, Nicola Gilberti, Veronica Vergani, Ilenia Delrio, Raffaella Spezi, Massimo Gamba, Angelo Costa, Roberto Gasparotti, Mauro Magoni, Alessandro Padovani, Anna Buchheim, Susanne Hörz-Sagstetter, Stephan Doering, Michael Rentrop, Peter Schuster, Peter Buchheim, Dan Pokorny, Melitta Fischer-Kern, Friedrich Stiefel, Céline Bourquin, Michael Saraga, Marta M. Maslej, Benjamin M. Bolker, Marley J. Russell, Keifer Eaton, Zachary Durisko, Steven D. Hollon, G. Marie Swanson, J. Anderson Thomson Jr., Benoit H. Mulsant, Paul W. Andrews, Paul Bausch, Thomas Fangmeier, Elisabeth Schramm, Ingo Zobel, Knut Schnell, Henrik Walter, Mathias Berger, Dieter Schoepf, Claus Normann, Sarah Drost, Satz Mengensatzproduktion, Druckerei Stückle, Druckerei Stückle
Journal: Psychotherapy and Psychosomatics (2017)