tbuckley/cabot-search huggingface dataset:
Abstract 4971: Dominant negative PD 1 armored CAR T cells induce remission in refractory diffuse large B-cell lymphoma (DLBCL) patients
Authors: Tong Chen
Journal: Cancer Research (2019)

Abstract Anti-CD19 chimeric antigen receptor (CAR19) autologous T cell treatment has been demonstrated as effective therapy to relapse/refractory B cell leukemia and lymphoma. However, CAR T shows limited efficacy in treatment of solid tumor or challenging with immunosuppressive characters, such as PD-L1+/hi lymphomas. PD-1/PD-L1 blockade have been shown as potentially effective anti-tumor therapies. We generated a lenti-vector incorporating an anti-CD19 secondary CAR molecule sequence with 4-1BB co-stimulatory domain and a dominant negative PD-1 sequence (Figure A). Compared with conventional CART cells, these ”armored” CART cells show enhanced capability of tumor killing after multiple-round challenging by PD-L1+CD19+ positive tumors, with a ”emory-like” phenotype(Figure B), suggesting dominant negative PD-1 molecule may protect CART cells from inhibition in tumor micro-environment. Here we report 2 cases of refractory diffuse large B cell lymphomas (DLBCLs) successfully treated with this novel dominant negative PD-1 armored humanized anti-CD19 CART cells. These two patients all failed to achieve response after multiple rounds of chemotherapy and radiotherapy, and infused with autologous CAR T cells at 5.23×10^6/kg and 1.97×10^6/kg during disease progress. Both patients showed significantly tumor mass decrease and SUV max decline in PET/CT results with ongoing response. (From 34.48 to 3.89 at day 27, from 25.02 to 2.38 at day 31, respectively.) (Figure C). Conclusion: These 2 cases revealed the significant anti-bulky lymphoma response of new type of CAR19 T cells with limited and tolerated cytokine release syndrome and central nervous system toxicity. This novel structure of dnPD1-hCAR19 may augment CART cells persistence in the patient after activation triggered by the lymphoma cells, suggesting that dnPD-1 molecule may enhance efficacy of CAR T cells in treatment of solid tumor. We are continuing to recruit more patients in clinical research. Citation Format: Tong Chen. Dominant negative PD 1 armored CAR T cells induce remission in refractory diffuse large B-cell lymphoma (DLBCL) patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4971.
DELAYED SUPPURATION DUE TO TYPHOID BACILLUS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SHAW ON THE OPSONIC INDEX.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PLoS Medicine Issue Image | Vol. 6(10) October 2009
Journal: PLoS Medicine (2009)

In April 2009, PLoS Medicine announced a "refocusing of the journal's priorities." Going forward, said the editors, the journal would prioritize papers addressing those diseases with the greatest global burden. It would also aim to be as broad a journal as possible, publishing papers that explored not just biological causes of illness, but also social, environmental, and political determinants of health. In this month's Editorial, as the journal marks its official five year anniversary, the editors look back over the last six months to assess the impact of the refocused scope. Image Credit: Adrian Boliston
On the diagnosis and treatment of breast cancer
Authors: M. S. Fox
Journal: JAMA (1979)

Randomized trials comparing surgical treatments of breast cancer show that radical mastectomy offers no greater benefit than simple mastectomy followed by radiotherapy. Furthermore, in terms of survival, radical mastectomy seems to be no better than wide excision followed by radiotherapy when the disease is clinically diagnosed as stage 1. The incidence of diagnosed breast cancer showed an 18% increase between 1935 and 1965 and a 50% increase between 1965 and 1975. However, breast cancer mortality has remained unchanged for at least the past 40 years. Analysis of survival curves of women with breast cancer suggests that two or more populations exist, with about 40% suffering fatal outcome unaffected by treatment. The remaining 60% exhibit a relative mortality only modestly different from that of women of similar ages without evidence of disease. Increasing detection of an entity that is histologically defined as malignant but biologically relatively benign could account for the observed increase in incidence. (<i>JAMA</i>241:489-494, 1979)
The albumin-functionality-test (AFT) as a new valuable tool to assess human albumin function and predict ACLF in patients with decompensated cirrhosis
Authors: Katja Waterstradt, Maurizio Baldassarre, Kerstin Schnurr, Agnese Antognoli, Giacomo Zaccherini, Manuel Tufoni, Paolo Caraceni
Journal: Journal of Hepatology (2020)
Epidemiology of human leishmaniasis in Greece, 1981-2011
Authors: K Gkolfinopoulou, N Bitsolas, S Patrinos, L Veneti, A Marka, G Dougas, D Pervanidou, M Detsis, E Triantafillou, T Georgakopoulou, C Billinis, J Kremastinou, C Hadjichristodoulou
Journal: Eurosurveillance (2013)

Leishmaniasis is endemic and mandatorily notifiable in Greece. Epidemiological surveillance data for leishmaniasis in Greece between 1981 and 2011 are presented. In 1998, the notification system began distinguishing between visceral and cutaneous leishmaniasis. The mean annual incidence of reported leishmaniasis cases between 1998 and 2011 was 0.36 per 100,000 population. Of a total 563 leishmaniasis cases reported after 1998, 523 (93%) were visceral leishmaniasis cases. Incidence of reported visceral leishmaniasis cases fluctuated during this period, generally decreasing after 2007, with a small re-increase in 2011. The mean annual incidence rate of reported visceral leishmaniasis cases was significantly higher in less than four year-olds (p <0.001). Leishmaniasis cases occurred both in the country mainland and islands. Between 1998 and 2011, Attica concentrated almost half of the reported visceral leishmaniasis cases, with incidence rates in western Attica and western Athens above 12.00 per 100,000 population. Compared to visceral leishmaniasis, cutaneous leishmaniasis had a rather sporadic distribution, with many prefectures appearing free of cases. From 2004, the notification also included risk factors and of 287 cases with known immune status, 44 (15%) were immunocompromised. Moreover having a dog at home was reported by 209 of 312 leishmaniasis cases (67%), whereas 229 of 307 cases (75%) reported the presence of stray dogs near their residence. Linking clinical surveillance data with laboratory data and improving collaboration with the veterinary public health sector are some of the future challenges for leishmaniasis surveillance in Greece.
Iatrogenic Muscle Fibrosis
Authors: Barry E. Levin
Journal: JAMA (1975)

Three patients had iatrogenic muscle fibrosis, without weakness or sensory loss. Deltoid muscle fibrosis produced the unique clinical sign of gradual, involuntary, and irreducible arm levitation. The third patient had both levitated arms and levitated legs, a result of injections in the rectus femoris muscles. Repeated intramuscular injections apparently resulted in muscle fibrosis and intramuscular nerve-twig damage. Pentazocine (Talwin) is a particularly offending agent. One patient showed an unusual tissue reaction to foreign material, which may have played a role in her muscle fibrosis. Nevertheless, dramatic recovery of muscle function followed surgical sectioning of the fibrous deltoid bands. (<i>JAMA</i>234:621-624, 1975)
Prevention of stroke in older persons with isolated systolic hypertension
Authors: Samuel J. Mann
Journal: JAMA (1991)

<h3>To the Editor.</h3> —The study, "Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension,"<sup>1</sup>concluded that treatment of isolated systolic hypertension in patients older than 60 years has considerable potential to decrease morbidity and disability. Despite this, I believe it would be a mistake to recommend treating all patients with isolated systolic hypertension rather than to seek to identify and treat only the subgroup at highest risk. Although the benefit was evident regardless of the initial systolic blood pressure, the authors conspicuously failed to mention whether a relationship was seen between the baseline DBP and the observed benefit. A related question is this: among patients with isolated systolic hypertension, did a treatment benefit patients with an elevated mean arterial pressure more than patients with a normal mean arterial pressure? The reduction in heart attack rate was greater than that seen in many other hypertension
Malignant Hypertension: Effect of Therapy on Renin and Aldosterone
Authors: R. G. MCALLISTER, CHARLES W. VAN WAY, KIOOMARS DAYANI, WILLIAM J. ANDERSON, EUGENE TEMPLE, ANDREW M. MICHELAKIS, WILLIAM S. COPPAGE, JOHN A. OATES
Journal: Circulation Research (1971)

Plasma renin activity (PRA) and aldosterone secretion rate (ASR) were measured in 22 patients in balance on a 100 mEq sodium diet during the malignant phase of hypertension and at intervals during long-term follow-up on pharmacological therapy. Three patients had normal PRA and ASR during malignant hypertension. Eighty-six per cent of patients had an increased ASR, but only in 36% was PRA concomitantly increased during malignant hypertension (one patient developed elevated PRA in the postmalignant period). PRA fell to normal in 87% of patients after antihypertensive therapy. ASR fell to normal on drug therapy in six patients, and in all of these there was a period during the postmalignant phase in which ASR was increased while PRA was normal or suppressed. In addition to this group with reversible hyperaldosteronism, all but two of the remaining patients with elevated ASR had periods during which ASR was increased at the same time that PRA was normal or suppressed. These data raise the possibility that either a nonrenin aldosterone-stimulating hormone is secreted in malignant hypertension or that excessive stimulation of the adrenal by angiotensin can lead to persistent hyperfunction of aldosterone-secreting cells with a quantitatively deranged feedback control. One patient had an aldosterone-secreting adenoma and had manifestations of the hyperaldosteronism antedating the development of malignant hypertension.
DNA Adducts As Biomarkers for Assessing Exposure to Polycyclic Aromatic Hydrocarbons in Tissues from Xuan Wei Women with High Exposure to Coal Combustion Emissions and High Lung Cancer Mortality
Authors: Judy L. Mumford, Xueming Lee, Joellen Lewtas, Tilan L. Young, Regina M. Santella
Journal: Environmental Health Perspectives (1993)

The high lung cancer rate in Xuan Wei, China, is associated with smoky coal use in unvented homes, but not with wood or smokeless coal use. Smoky coal combustion emits higher polycyclic aromatic hydrocarbon (PAH) concentrations than wood combustion. This study used DNA adducts as biomarkers for human exposure to PAH from combustion emissions. DNA adducts were determined by enzyme-linked immunosorbent assays (ELISA) in placentas and peripheral and cord white blood cells (WBC) from Xuan Wei women burning smoky coal or wood and from Beijing women using natural gas. Color ELISA gave positive results in 58, 47, and 5% of the placentas from Xuan Wei women burning smoky coal without and with chimneys, and from Beijing women, respectively. Fluorescence ELISA indicated that 46, 65, 56, and 25% of placentas were positive from Xuan Wei women who lived in houses without and with chimneys, Xuan Wei women burning wood, and Beijing controls, respectively. Peripheral WBC samples were positive in 7/9, 8/9, and 3/9 for the Xuan Wei women who lived in houses without and with chimneys and Beijing women, respectively. PAH-DNA adducts were detected in a higher percentage of placentas from Xuan Wei women living in houses exposed to smoky coal or wood emissions than from those of the Beijing controls. No dose-response relationship was observed between the air benzo[alpha]pyrene concentrations and DNA adduct levels or percentage of detectable samples. The results suggest that DNA adducts can be used as a qualitative biomarker to assess human exposure to combustion emissions.
Medical Electricity, Roentgen Rays and Radium, with a Practical Chapter on Phototherapy.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Silicone breast implants and risk of cancer?
Authors: J. K. McLaughlin
Journal: JAMA (1995)

<h3>In Reply.</h3> —We thank Dr Cates for his letter describing the problems with hierarchical authorship, and we appreciate the opportunity to address this subject again.<sup>1,2</sup> Cates poses several questions regarding his scenario. To answer his first question, no one who has offered "no input" into a manuscript should be considered an author and given a guest position in the byline, regardless of position in the hierarchy. When a senior-level manager provides "little input," then perhaps that person could be considered an author if she or he has participated sufficiently in the work to take public responsibility for it and made substantial contributions in each of the following three areas: (1) conception and design or analysis and interpretation of data; (2) drafting the article or revising it critically for important intellectual content; and (3) final approval of the version to be published.<sup>3</sup> Cates also asks how the colleague who
HCV care cascade of PWID enrolled in methadone substitution treatment program in Georgia - is this the first group of population in which hepatitis C will be eliminated in Georgia?
Authors: Ketevan Stvilia, Amiran Gamkrelidze, Irma Khonelidze, Vladimer Getia, Lia Gvinjilia, Tinatin Kuchuloria, Maia Tsereteli
Journal: Journal of Hepatology (2020)
Leon Schiff state-of-the-art lecture
Journal: Hepatology (2003)

Automated systems for monitoring behaviour of cows within dairy production are increasing and developments in technology provide new opportunities in this area. This study aimed to validate the use of a 3D activity logger (HOBO® Pendant G Data Logger), that registers the cow's head positions during grazing, to distinguish grazing behaviour from non-grazing behaviour.20 lactating dairy cows of the breed Swedish Red were included in the trial. All cows were observed for 30 min each day either in the morning or afternoon. The behavioural observations were conducted by two trained observers during 5 h a day for ten days, 2.5 h in the morning (9:30–12:00 am) and 2.5 h in the evening (06:00–08:30 pm). Each cow had a logger attached to the right bottom side of the halter and the logging interval was set to 5 s, which means that the head inclination was measured every fifth second. Furthermore an IceTag3D™ logger was attached to the right hind leg of each cow in order to evaluate if this information together with the information from the 3D activity sensor could increase the precision of the prediction. The DISCRIM procedure in SAS 9.12 was used to find the optimal value of a linear discrimination between grazing and non-grazing registrations and the 3D activity sensor was validated with 5 s, 5 min and 10 min logging intervals between observations points against the visual observation of grazing behaviour. The 5 and 10 min logging point was taken from the 5 s logging point occurring with 5 and 10 min interval.The sensitivity (recognizing grazing behaviour as grazing) of the 3D activity sensor without or with the information from the IceTag logger with 10 min interval was below 60% and thus not useful in determining grazing behaviour. However, the sensitivity of the 3D activity sensor alone was 83.6 and 85.5% for 5 s and 5 min respectively. The specificity (recognizing non-grazing behaviour as non-grazing) of the 3D activity sensor was 79.9 and 82.1% and the precision (proportion of calculated gracing behaviour that is real grazing behaviour) was 74.6 and 77.6% for 5 s and 5 min respectively. When the information from the IceTag3D™ was added to the data the sensitivity remained the same while the specificity increased to 90.2 and 90.5% and the precision was 85.8 and 86.8% for 5 s and 5 min respectively.It is concluded that a 3D activity logger is a useful tool for a continuous automatic registration of grazing behaviour in dairy cows.
Amyotrophic lateral sclerosis. No increase among US construction workers in Guam
Authors: J. A. Brody
Journal: JAMA (1978)

The rate of amyotrophic lateral sclerosis (ALS) among stateside construction workers on Guam was similar to that of US resident white men. Of 12,601 men who worked on Guam for one year or more from 1945 to 1954, we were able to follow up 10,049 until 1970 through the Social Security Administration. Of these workers, 1,958 had died, and the cause of death was recorded for all but 335. There were three deaths from ALS. Residence on Guam as an adult did not predispose to a high rate of ALS. (<i>JAMA</i>240:551-552, 1978)
Government Prizes for Important Discoveries in Medicine.—
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer
Authors: Aditya Bardia, Ingrid A. Mayer, Jennifer R. Diamond, Rebecca L. Moroose, Steven J. Isakoff, Alexander N. Starodub, Nikita C. Shah, Joyce O’Shaughnessy, Kevin Kalinsky, Michael Guarino, Vandana Abramson, Dejan Juric, Sara M. Tolaney, Jordan Berlin, Wells A. Messersmith, Allyson J. Ocean, William A. Wegener, Pius Maliakal, Robert M. Sharkey, Serengulam V. Govindan, David M. Goldenberg, Linda T. Vahdat
Journal: Journal of Clinical Oncology (2017)
DEXA-Reply
Authors: Shirley E. Kellie
Journal: JAMA (1992)

<h3>In Reply.</h3> —Drs Börner and Schneider note that compared with DEXA, in which measurements of areal bone mineral density (BMD) are made in grams per square centimeter, quantitative computed tomography (QCT), a three-dimensional imaging technique, is capable of assessing bone volume more directly and measures BMD in grams per cubic centimeter. This same observation is made throughout the Diagnostic and Therapeutic Assessment (DATTA) report on DEXA. It follows that QCT separately analyzes cortical and trabecular bone mineral—an important issue insofar as trabecular bone has eight times the bone turnover rate as cortical bone, and bone loss, therefore, first manifests itself in skeletal sites composed largely of trabecular bone such as the spine. Consequently, as noted by Börner and Schneider and in the DATTA report on DEXA, QCT measurements of BMD have somewhat better predictive value for spine fractures than do DEXA measurements. Börner and Schneider, noting the wide demand and