tbuckley/cabot-search huggingface dataset:
Treating obesity.
Authors: J S Garrow
Journal: BMJ (1991)

consulting and in cross cultural consulting should be available to all health professionals and differs from that in any other communication skills only in emphasis.How many of us have listened to or watched any of our own health education consultations with anyone, let alone with someone from a different culture?The Health Education Authority has a list of useful resources for those wishing to provide health promotion to different ethnic groups.8Providing material in different languages may be costly: we estimate that printed materials for any campaign cost £750 for each language (including English), meaning that the costs of a campaign may have to be multiplied by 10 or more to reach all the communities targeted in an inner city.Advice about preparing material in different languages is available,9 and several commercial companies provide translation and typesetting in London.(A list is held by City and Hackney Health Promotion Unit and may therefore be held by other interested organisations.)Many inner city local authorities also run interpretation departments.Despite these facilities, however, of 97 district health authorities providing a health education leaflet with their invitation for a cervical smear test, only five provided special material for women from ethnic minorities.'0Health authorities should consider employing specialist health education officers for ethnic minorities.More health education officers should be drawn from ethnic minorities, and all health education officers, regardless of ethnic back- ground, should receive relevant training.More research is needed into what are appropriate methods of health pro- motion.
Genetic and Environmental Factors Affecting Host Response to Drugs and Other Chemical Compounds in Our Environment
Authors: Elliot S. Vesell, G. Thomas Passananti
Journal: Environmental Health Perspectives (1977)

Compared to laboratory animals, humans are extremely heterogenous with respect to the many factors that can influence the distribution and biological effects of toxic chemicals. This heterogeneity can prevent an accurate assessment of the impact of a particular toxic compound on the health of an individual subject. Some of the factors that can significantly modify the host response to certain drugs, which serve in this review as a model for environmental chemicals, are enumerated and discussed. Although the mechanisms by which many of these factors modify the biological effects of certain environmental chemicals and drugs have been determined in some cases, better definition of the nature of interactions between these factors and environmental chemicals in a particular individual is required at a biochemical and molecular level. Recommendations are offered for the further development of our knowledge concerning interactions between environmental chemicals and such factors in a particular individual.
IMAGING STUDIES WITH TC-99M LABELED TUMOR SPECIFIC MONOCLONAL ANTIBODIES TO A TRANSPLANTABLE MURINE TUMOR.
Authors: Daphne J.Y. Mew, L. N. Alcorn, J. G. Levy, D. M. Lyster, R. T. Morrison
Journal: Clinical Nuclear Medicine (1983)

Mew, Daphne J.Y.; Alcorn, L. N.; Levy, J. G.; Lyster, D. M.; Morrison, R. T. Author Information
Outcome After Orthotopic Cardiac Transplantation in Adults With Congenital Heart Disease
Authors: Jacqueline M. Lamour, Linda J. Addonizio, Mark E. Galantowicz, Jan M. Quaegebeur, Donna M. Mancini, Maryanne R. Kichuk, Ainat Beniaminovitz, Robert E. Michler, Alan Weinberg, Daphne T. Hsu
Journal: Circulation (1999)

Background —Advances in surgical and medical management have greatly improved long-term survival rates in patients with congenital heart disease (CHD). As these patients reach adulthood, myocardial dysfunction can occur, leading to cardiac transplantation. Methods and Results —We reviewed the pretransplantation and posttransplantation courses of 24 patients &gt;18 years old (mean age, 26 years; range, 18 to 56 years) with CHD who received a transplant between January 1985 and September 1998. The relation between preoperative and perioperative risk factors for complications and death was assessed. Single ventricle was the pretransplantation diagnosis for 12 patients (50%), and d -transposition of the great vessels was the diagnosis for 4 patients (16%). Twenty-two patients had a mean of 2 previous operations. At cardiac transplantation, additional surgical procedures were required to correct extracardiac lesions in 18 patients (75%). Refractory heart failure was present in 22 patients, significant cyanosis was present in 7, and protein-losing enteropathy was present in 4. There were 5 early deaths due to bleeding (n=3) and infection (n=2). The Kaplan-Meier survival rate after cardiac transplantation was 79% at 1 year and 60% at 5 years . No anatomic or surgical risk factor was predictive of death. The outcome of patients with CHD who received a transplant was compared with that for patients without CHD (n=788). Mean bypass and ischemic times were significantly longer in patients with CHD than in patients without CHD. Survival rates after transplantation did not differ significantly between patients with and those without CHD ( P =0.83). Conclusions —Successful cardiac transplantation is obtainable in adults with complex CHD, with an outcome similar to that of patients without CHD. A detailed assessment of cardiac anatomy and careful surgical planning are essential to the pretransplantation and posttransplantation management of these patients.
Dumping-Reply
Authors: Olga Jonasson
Journal: JAMA (1987)

<h3>In Reply.—</h3> No one can condone abuses of patients' rights and safety when they are transferred to a public hospital, whether for medical or financial reasons. As Dr Franklin points out, a system of physician-to-physician communication and a set of guidelines to guard patient safety must be in place. Such a system has been in practice in the specialized surgical units at Cook County Hospital for years. This is not to say that each and every transfer event is trouble free, but dangerous violations of patients' rights and safety are rare. Essentially all eligible injured and acutely ill preoperative patients are accepted for transfer, and the longestablished agreement among four specialized surgical units (surgery, trauma, burn, and neurosurgery)—that all critical-care beds are treated as a common resource for surgical patients—has minimized bed-space problems. We routinely advise the referring institution to send any emergency patient or one whose condition is unstable
Chymopapain chemonucleolysis in lumbar disk disease
Authors: L. L. Wiltse
Journal: JAMA (1975)

Experience with chymopapain chemonucleolysis in 1,200 cases of lumbar disk disease indicates that it is an effective method of relieving pain resulting from an abnormal intervertebral disk. Complications were few; anaphylaxis occurring immediately after injection was by far the most serious. With the use of a corticosteroid and an antihistamine in preoperative preparation, the incidence of anaphylaxis has dropped, although it still occurs. On long-term follow-up, chemonucleolysis appears to be as good as laminectomy in properly selected cases. (<i>JAMA</i>231:474-479, 1975)
Yale Journal of Biology and Medicine, New Haven
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Neoantigens
Authors: Ton N. Schumacher, Wouter Scheper, Pia Kvistborg
Journal: Annual Review of Immunology (2018)

Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell-based immune system frequently responds to the neoantigens that arise as a consequence of this DNA damage. Furthermore, recognition of neoantigens appears an important driver of the clinical activity of both T cell checkpoint blockade and adoptive T cell therapy as cancer immunotherapies. Here we review the evidence for the relevance of cancer neoantigens in tumor control and the biological properties of these antigens. We discuss recent technological advances utilized to identify neoantigens, and the T cells that recognize them, in individual patients. Finally, we discuss strategies that can be employed to exploit cancer neoantigens in clinical interventions.
A pilot study for cellular detection of circulating tumor cells and disseminated tumor cells of patients with hepatocellular carcinoma.
Authors: Nozomi Minagawa, Hideyasu Sakihama, Nozomi Kobayashi, Mito Obara, Susumu Shibasaki, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Yousuke Tsuruga, Shigenori Homma, Hideki Yokoo, Hirofumi Kamachi, Hideki Kawamura, Norihiko Takahashi, Toshiya Kamiyama, Akinobu Taketomi
Journal: Journal of Clinical Oncology (2014)

11041 Background: Circulating tumor cells (CTC) in peripheral blood (PB) and disseminated tumor cells (DTC) in bone marrow (BM) have been recently focused as predictive and prognostic markers in solid tumors. But hepatocellular carcinoma (HCC) usually lacks epithelial antigens, only a few reports described CTC or DTC at a cellular level. The aim of this study is to establish methodology for detecting CTC and DTC in HCC at a cellular level, and to analyze with clinicopathological findings. Methods: PB (n-36) and BM samples (n-20) were preoperatively collected from patients with HCC between October 2011 and July 2013. Mononuclear cells were collected by Ficoll gradient separation. CD45+ cell population was deleted through magnetic activated cell sorting system. Subsequently, double immunofluorescence for AFP, Arginase-1 or Hep-Par1 and CD45 was performed. PB samples from 20 healthy volunteers and BM samples from 3 patients with benign disease were used as controls. Our protocol has been approved by the ethical committee of Hokkaido University Hospital and written informed consent was obtained from all enrolled patients. Results: Positive rates of CTC and DTC were 63.8% (23/36) and 65.0% (13/20). No CTC or DTC was found in the control groups. Detection of CTC or DTC was closely correlated with preoperative tumor marker and portal invasion. Positive rates of preoperative AFP and PIVKA-II in CTC+, DTC+ patients were statistically higher than that of CTC+ or DTC+ patients (AFP:73.9%, 84.6% vs 38.4%, 28.6%,p=0.04, PIVKA-II: 86.9%, 92.3% vs 53.8%, 57.1%, p=0.02). Detection of CTC or DTC is also correlated portal invasion (60.8%, 61.5% vs 7.7%, 0%,p=0.04). There’re higher risk of distant metastasis in CTC+ or DTC+ patients, compared with that of CTC- or DTC- patients (47.8%, 53.8% vs 7.7%, 0%, p=0.04).There’re significant differences in the distant metastasis-free survival (p=0.01), but not in the overall survival and in the liver recurrence-free survival (p= 0.94, 0.05). Conclusions: Our protocol might provide highly specific detection of CTC, DTC from HCC patients. Detection of CTC or DTC might contribute to considering postoperative therapeutic strategies.
Letter: Faecal fibre fortunes.
Authors: J Marks, W Lawler
Journal: BMJ (1975)

have been reported,' but complete obstruc- tion is unusual.We feel that the reason for its occurrence in the case reported here is the unusual length of aorta involved, which prevented any displacement of the oeso- phagus.Unless the existence of this phenomenon is appreciated it may lead to a mistaken diagnosis of achalasia or carcinoma of the oesophagus.-Weare, etc.,
Important Notice Concerning Library Wants and Supplies.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recovery Rate and Prognosis in Older Persons Who Develop Acute Lung Injury and the Acute Respiratory Distress Syndrome
Journal: Annals of Internal Medicine (2002)

Summaries for Patients1 January 2002Recovery Rate and Prognosis in Older Persons Who Develop Acute Lung Injury and the Acute Respiratory Distress SyndromeSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-1-200201010-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Elderly people are much more likely to develop respiratory failure and require the use of a respirator than younger people. On the other hand, the results of respirator use in the elderly do not appear to be as good as in younger people, but the exact relationship between age and outcome is uncertain. The National Heart, Lung, and Blood Institute (NHLBI) sponsored a large study on acute lung injury that leads to respiratory failure. The data were made available to other researchers for further analysis.Why did the ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Recovery Rate and Prognosis in Older Persons Who Develop Acute Lung Injury and the Acute Respiratory Distress Syndrome.” It is in the 1 January 2002 issue of Annals of Internal Medicine (volume 136, pages 25-36). The authors are EW Ely, AP Wheeler, BT Thompson, M Ancukiewicz, KP Steinberg, and GR Bernard, for the Acute Respiratory Distress Syndrome Network.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRecovery Rate and Prognosis in Older Persons Who Develop Acute Lung Injury and the Acute Respiratory Distress Syndrome E. Wesley Ely , Arthur P. Wheeler , B. Taylor Thompson , Marek Ancukiewicz , Kenneth P. Steinberg , Gordon R. Bernard , and Metrics Cited byTrends and challenges in the management of tracheostomy in older people: The need for a multidisciplinary team approach 1 January 2002Volume 136, Issue 1Page: I-68KeywordsAcute respiratory distress syndromeElderlyHeart failureIntensive care unitsLongitudinal studiesLungsOxygenRespiratory failureThoraxVentilators ePublished: 1 January 2002 Issue Published: 1 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Transdermal Granisetron for the prevention of chemotherapy-induced nausea and vomiting in metastatic colorectal cancer patients with high risk of bowel obstruction treated with Temozolomide
Authors: M.A. Calegari, S. Monterisi, A. Orlandi, A. Inno, S. Corallo, R. Barile, C. Di Dio, V. Zurlo, M. Basso, A. Cassano, C. Barone
Journal: Annals of Oncology (2016)
Incorrect and Misleading Data
Authors: Jonathan Ellen, Lauren Greenberg, James Korelitz, Efrat Amitay
Journal: JAMA Pediatrics (2015)

done so (as described in greater detail in other manuscripts more focused on this process).We are also currently in the process of examining the relationship of structural change achievement in communities with more intermediate or proximal outcomes, such as HIV-related stigma or the perception of community resources.As stated in our study, while there were some suggested associations between our measures of structural changes and behavioral risk factors, there were several study design and practical issues that made it difficult to formally show statistical significance for some of our study end points.We feel we were successful in documenting those design and practical issues associated with our broad-based approach and that our findings will inform researchers as they develop and evaluate new structural change programs.
Taenia in Expulsis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ARMY MEDICAL DEPARTMENT.II. A HISTORICAL SKETCH.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Determination of Bisphenol A and Related Aromatic Compounds Released from Bis-GMA-Based Composites and Sealants by High Performance Liquid Chromatography
Authors: Rosa Pulgar, M. Fatima Olea-Serrano, Arancha Novillo-Fertrell, Ana Rivas, Patricia Pazos, Vicente Pedraza, Jose-Manuel Navajas, Nicolas Olea
Journal: Environmental Health Perspectives (2000)

Most of the composites and sealants used in dentistry are based on bisphenol A diglycidylether methacrylate (Bis-GMA). Reports revealed that in situ polymerization is not complete and that free monomers can be detected by different analytic methods. Concerns about the estrogenicity of bisphenol A (BPA) and other aromatic components leached from commercial products have been expressed. We studied biphenolic components eluted from seven composites and one sealant before and after in vitro polymerization using HPLC and gas chromatography/mass spectrometry and we investigated how pH modifications affect the leaching of these components. We found BPA (maximal amount 1.8 microg/mg dental material), its dimethacrylate derivative (Bis-DMA, 1.15 microg/mg), bisphenol A diglycidylether (6. 1 microg/mg), Bis-GMA (2.0 microg/mg), and ethoxylate and propoxylate of bisphenol A in media in which samples of different commercial products were maintained under controlled pH and temperature conditions. Our results confirm the leaching of estrogenic monomers into the environment by Bis-GMA-based composites and sealants in concentrations at which biologic effects have been demonstrated in in vivo experimental models. The main issue with implications for patient care and dentist responsibility is to further determine the clinical relevance of this estrogenic exposure.
Reply
Authors: Ann T. Tong, Raymond Roudaut, Mehmet Özkan, Alex Sagie, Maie S.A. Shahid, Sergio C. Pontes, Francesc Carreras, Steven E. Girard, Samir Arnaout, Raymond F. Stainback, Ravi Thadani, William A. Zoghbi
Journal: Journal of the American College of Cardiology (2005)
THE FORMATION OF VISCERAL CASTS OR MOLDS ON SEROUS MEMBRANES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal