tbuckley/cabot-search huggingface dataset:
Clinical and pathologic correlation of the activated form of the estrogen receptor beta (ERβ) in breast cancer (BC).
Authors: Emilie Hutt, Jacques Bosq, Erard M. Gilles, Alexander Zukiwski, Charline Alleaume, Barthelemy Octavius Gilles, Jacques Bonneterre
Journal: Journal of Clinical Oncology (2014)

3046 Background: ERβ is antagonized by anti-estrogens and has been associated with a better prognosis although its role is unclear. Experimentally, ERβ has a nuclear biology common to the steroid nuclear receptors. In the absence of estrogenic ligand, it is evenly distributed in nuclei; when exposed to ligand, ERβ migrates to form sub-nuclear aggregates that can be detected by immunofluorescence microscopy. Thus, two distinct nuclear patterns, diffuse (D) or aggregated (A) are observed which correspond to the receptors’ functional states. Similarly to previous work on ERα and PR (ASCO 2013 abstr.# e11535 & 593), an immunohistochemistry (IHC) method has been developed to characterize the nuclear distribution patterns which may indicate whether ERβ is transcriptionally active or not in PEFF tissues. The goal of the study is to analyze whether activated ERβ is associated with anti-estrogen treatment outcome. Methods: 662 archived BC biopsies have been obtained along with clinical and pathological data. Biopsies were analyzed for standard HES, ERα, ERβ, PR and Ki67. ERβ positivity was determined with the 14C8 antibody (Abcam) and the nuclear distribution pattern analyzed at x1000 magnification. Results: 392 cases have been analyzed to date. Mean Age: 57 (17-89). Median follow up 36 months (mo). Histology: ductal 82% lobular 15% other 3%; ERαpos 78% PRpos 78%. Adjuvant chemotherapy 46%, Hormone therapy 85%. Stage I 44%, II 48%, III 8%. Grade I 25%, II 50%, III 25%. ERβ was positive in 57% of the cases (ERβpos). ERβ was activated (A- ERβ) in 35% of the ERβpos biopsies, and non-activated (D- ERβ) in 65% ERβpos . A-ERβ was associated with higher grade (p < 0.000, p = 0.007); ERβ, PR, HER2, Ki67, staging were not associated with ERβpos nor A-ERβ. Local or distant Progressive disease (PD) was evident in 19% of cases and was not associated with ERβpos or A-ERβ (p=0.87). With DFS defined as time to PD or death (5 year cut-off), neither ERβposnor A-ERβ were associated with a better DFS (HR: 1.02 and 0.98). Conclusions: In contrast to ERα, preliminary results show that ERβ positivity and ERβ activation status were associated with higher pathological grade but not with other pathological or clinical variables.
Approaches to the Evaluation of Chemical-Induced Immunotoxicity
Authors: Krzysztof Krzystyniak, Helen Tryphonas, Michel Fournier
Journal: Environmental Health Perspectives (1995)

The immune system plays a crucial role in maintaining health; however, accumulating evidence indicates that this system can be the target for immunotoxic effects caused by a variety of chemicals including the environmental pollutants of polychlorinated biphenyls, chlorinated dibenzo-p-dioxins, pesticides, and heavy metals.Adverse chemical-induced immunomodulation, which is studied within the discipline of immunotoxicology, may be expressed either as immunosuppressionfimmunodepression or immunoenhancement.The former may be manifested either as decreased resistance to opportunistic viral, bacterial, fungal, and other infectious agents or increased susceptibility to cancer.Immunoenhancement on the other hand may either increase the risk of autoimmune reactions or result in allergic reactions.This paper attempts to integrate several aspects of the immune system that are relevant to the assessment of potentially immunotoxic chemicals.
Primary cutaneous nocardiosis
Authors: T. K. Satterwhite
Journal: JAMA (1979)

Seven patients with primary cutaneous nocardiosis were seen during a 20-month period. Six patients had a history of local trauma to an extremity or did frequent yard work. The spectrum of clinical disease included cellulitis, pustules, pyoderma, or lymphocutaneous syndrome mimicking sporotrichosis. Evidence of<i>Nocardia</i>infection elsewhere was absent, and no patient had a serious underlying disease.<i>Nocardia brasiliensis</i>was isolated from four cases, and N asteroides was identified in the other three patients. In two patients, disease resolved without chemotherapy, while a short course of a sulfonamide with or without trimethoprim therapy was successful in the remaining cases. The relatively benign nature of this disease, the usual failure to obtain cultures of superficial skin infections, and our accumulation of seven cases in less than two years suggest this disease is more common than previously recognized. (<i>JAMA</i>242:333-336, 1979)
AMA/Glaxo Achievement Awards
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatology highlights
Authors: Nicholas Russo, Robert S. Brown, Nicole T. Shen, Joseph F. Pisa, Saurabh Mukewar, Zaid H. Tafesh, Russell Rosenblatt, Robert E. Schwartz, Vikas Gupta, Aleksey Novikov, Shirley Cohen‐Mekelburg
Journal: Hepatology (2018)

Russo, Nicholas1; Brown, Robert S. Jr.1; Shen, Nicole T.1,†; Pisa, Joseph F.1; Mukewar, Saurabh2,‡; Tafesh, Zaid H.1,†; Rosenblatt, Russell1,†; Schwartz, Robert E.1; Gupta, Vikas1,†; Novikov, Aleksey1,†; Cohen‐Mekelburg, Shirley1,† Author Information
Recurrent Gastric Ulcer with Spontaneous Gastrojejunal and Gastrocolic Fistulas
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic intrahepatic cholestasis with granulomas and biliary cirrhosis. Enigmatic disease and therapeutic dilemma
Authors: E. Thomas
Journal: JAMA (1977)

CHRONIC intrahepatic cholestasis, a syndrome characterized by jaundice, pruritus, and hepatomegaly, may occur as a result of a variety of causes. When associated with hepatic granulomas, many cases are due to adverse drug reactions, Hodgkin's disease, Crohn's disease, and postnecrotic cirrhosis, and these are relatively easily distinguished. Infections from viral agents, brucellosis and Q fever, and fungi may be excluded as causes by appropriate tests. Tuberculosis may be difficult to prove at times. Primary biliary cirrhosis, which also is seen generally as chronic intrahepatic cholestasis, may be closely mimicked by the cholestasis that has been recently noted to rarely occur in patients with sarcoidosis.<sup>1,2</sup>Advanced states of the two diseases may be indistinguishable, as exemplified by the patient described here. <h3>Report of a Case</h3> A 62-year-old woman was admitted to Westchester County Medical Center on April 23, 1976, for investigation of pruritus and elevated serum alkaline phosphatase values. The patient,
Methods of Treatment in Postencephalitic Parkinsonism
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2627: High Energy Defibrillation Impairs Myocyte Contractility and Intracellular Calcium Dynamics
Authors: Giuseppe Ristagno, Tong Wang, Min-Shan Tsai, Shijie Sun, Wanchun Tang, Max H Weil
Journal: Circulation (2007)

Introduction. High energy defibrillation is recognized to increase postresuscitation myocardial dysfunction. We examined the effects of defibrillation energies on contractility and intracellular Ca 2+ dynamics at the single cardiomyocyte level. Hypothesis. Increasing the defibrillation energy would produce correspondent reduction in myocyte contractility and impairment of intracellular Ca 2+ dynamics. Methods. Ventricular cardiomyocytes, obtained from adult Sprague-Dawley rat hearts, were loaded with Fura-2/AM. The myocytes were then placed in a chamber mounted on an inverted microscope and superfused with a buffer solution at 37 °C. The cells were field stimulated to contract at 0.5 Hz with a field stimulator (IonOptix Corporation, Milton, MA). Mechanical properties were assessed using a video-based edge-detection system (IonOptix Corporation, Milton, MA) and expressed as cell shortening percentage. Intracellular Ca 2+ dynamics were evaluated with a dual-excitation fluorescence photomultiplier system (IonOptix Myocam System) and inferred from the ratio of the fluorescence intensity at the two different wavelengths. Myocytes were randomized into 4 groups of 10 cells each, to receive: a single 0.5 Joule biphasic shock; a single 1 Joule biphasic shock; a single 2 Joule biphasic shock; and a control group without shock. The myocytes were paced for additional 4 min after the shock. Results. A 0.5 Joule shock did not have effects on cardiomyocyte contractility and intracellular Ca 2+ dynamics. Higher energy shock, i.e. 1 or 2 Joule, significantly impaired cardiomyocyte contractility and intracellular Ca 2+ dynamics (p &lt; 0.01). These adverse effects were greater when higher energy was employed (p &lt; 0.01). Table Conclusions. Higher defibrillation energy significantly impairs myocyte contractility. Reductions in cardiomyocyte shortening and intacellular Ca 2+ dynamics abnormalities were greater when higher energy shock was employed. Results
Serum Potassium is not Associated with Blood Pressure Tracking in the Framingham Heart Study
Authors: Craig R Walsh, Martin G Larson, Vasan S Ramachandran, Danial Levy
Journal: Circulation (2001)

P52 Introduction Secondary and inherited, monogenic forms of hypertension (HTN) are often associated with low serum potassium (K). We hypothesized that low K may identify individuals at risk for progression of blood pressure (BP) stage. Methods 2358 participants (1066 men 1292 women) in the Framingham Heart Study free of HTN and not taking drugs affecting K who had K measured in 1979-83 were followed for progression of BP stage and development of HTN. Progression of BP stage was defined as increment of ≥1 JNC-VI BP category between baseline and follow-up exams. Results There were no differences in baseline systolic or diastolic BPs across K quartiles. Over 4 years of follow up, 36% progressed by ≥1 JNC-VI BP category. In a multivariable-adjusted logistic regression model, there was no significant association between K quartile and risk of BP progression ( table). During follow up, 14% progressed to HTN. After adjustment for multiple confounders, there was no significant association between K quartile and risk of progression to HTN ( table). Conclusions In our community-based sample, K was not associated with current BP, longitudinal BP tracking, or progression to HTN. Table 1.
VACCINATION AND SMALLPOX.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Men’s Mental Health Disparities
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence and reasons of drop out in successive transradial procedures in one arm Hideaki Sakai, Haruto Ohe, Takashi Harada, Takeshi Yonashiro, Kiyoshi Ozumi, Satoshi Ikeda, Shigeru Kohno. Kitakyushu city Yahata Hospital, Kitakyushu, Japan
Journal: Journal of the American College of Cardiology (2001)
Aortic Stenosis
Authors: Faisal G. Bakaeen, Todd K. Rosengart, Blase A. Carabello
Journal: Annals of Internal Medicine (2017)

This issue provides a clinical overview of aortic stenosis, focusing on screening, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers.
Psychological Hazards of Convalescence Following Myocardial Infarction
Authors: Howard A. Wishnie
Journal: JAMA (1971)

Emotional problems during convalescence from myocardial infarction seriously hamper rehabilitation and the return to work. Of the 24 patients studied, 21 rated themselves as anxious or depressed and 18 were judged by the examiner to require either a tranquilizer or antidepressant. Sleep disturbances occurred in 15 patients and disruptive family quarrels over aspects of convalescence took place in 18 cases. There was a uniform tendency to avoid taking sedatives, to minimize symptoms during follow-up examinations, and to retain harmful habits. Eleven patients did not return to work, nine for psychological reasons, and those who did resume part or full-time employment experienced anxiety or augmentation of angina or dyspnea or both. Suggestions are offered which may help to lessen the emotional hazards of convalescence.
Landmark perspective: Walter Reed and yellow fever
Authors: W. B. Bean
Journal: JAMA (1983)

Yellow fever was a disease of unknown cause, curious, almost haphazard spread, short duration, and, often, a high fatality rate. It died out soon after a frost and did not appear in cool climates or high elevations. Some thought filth caused its spread — that it arose in the fetid, reeking decay around docks. Others believed it to be imported, mainly by ships from tropical lands. It rarely attacked nurses, doctors, or hospital attendants. The very mystery increased the sickening fear it created. It brought business to a halt. People fled from it if they could. Thus, when the manner of its spread was learned and could be stopped, it was stripped of its lethal secrets. We today who go careless and carefree are a forgetful people. The article reprinted in this issue ofThe Journalwas the classic contribution of the Yellow Fever Board appointed by Surgeon General Sternberg
Incorrect Values and Excluded Units of Measure
Authors: Massimo Girardis
Journal: JAMA (2017)

Mohammad H. Forouzanfar, PhD; Patrick Liu, BS; Gregory A. Roth, MD; Marie Ng, PhD; Stan Biryukov, BS; Laurie Marczak, PhD; Lily Alexander, BA; Kara Estep, MPA; Kalkidan Hassen Abate, MS; Tomi F. Akinyemiju, PhD; Raghib Ali, FRCP; Nelson Alvis-Guzman, PhD; Peter Azzopardi, MEpi; Amitava Banerjee, DPhil; Till Bärnighausen, MD; Arindam Basu, PhD; Tolesa Bekele, MPH; Derrick A. Bennett, PhD; Sibhatu Biadgilign, MSc; Ferrán Catalá-López, PhD; Valery L. Feigin, PhD; Joao C. Fernandes, PhD; Florian Fischer, MPH; Alemseged Aregay Gebru, MPH; Philimon Gona, PhD; Rajeev Gupta, PhD; Graeme J. Hankey, MD; Jost B. Jonas, MD; Suzanne E. Judd, PhD; Young-Ho Khang, MD; Ardeshir Khosravi, PhD; Yun Jin Kim, PhD; Ruth W. Kimokoti, MD; Yoshihiro Kokubo, PhD; Dhaval Kolte, PhD; Alan Lopez, PhD; Paulo A. Lotufo, DrPH; Reza Malekzadeh, MD; Yohannes Adama Melaku, MPH; George A. Mensah, MD; Awoke Misganaw, PhD; Ali H. Mokdad, PhD; Andrew E. Moran, MD; Haseeb Nawaz, MD; Bruce Neal, PhD; Frida Namnyak Ngalesoni, MSc; Takayoshi Ohkubo, MD; Farshad Pourmalek, PhD; Anwar Rafay, MS; Rajesh Kumar Rai, MPH; David Rojas-Rueda, PhD; Uchechukwu K. Sampson, MD; Itamar S. Santos, PhD; Monika Sawhney, PhD; Aletta E. Schutte, PhD; Sadaf G. Sepanlou, PhD; Girma Temam Shifa, MPH; Ivy Shiue, PhD; Bemnet Amare Tedla, BS; Amanda G. Thrift, PhD; Marcello Tonelli, MD; Thomas Truelsen, DMSc; Nikolaos Tsilimparis, PhD; Kingsley Nnanna Ukwaja, MD; Olalekan A. Uthman, PhD; Tommi Vasankari, PhD; Narayanaswamy Venketasubramanian, FCRP; Vasiliy Victorovich Vlassov, MD; Theo Vos, PhD; Ronny Westerman, PhD; Lijing L. Yan, PhD; Yuichiro Yano, MD; Naohiro Yonemoto, MPH; Maysaa El Sayed Zaki, PhD; Christopher J. L. Murray, DPhil
Medicare Problems
Authors: Leonard S. Ellenbogen
Journal: JAMA (1966)

<h3>To the Editor:—</h3> It is unfortunate that Dr. Roth's otherwise comprehensive report (<b>197</b>:347, 1966) did not discuss a serious inequity in the provisions of Medicare which extends outpatient diagnostic services to beneficiaries under parts A and B, subject to a $20 deductible in hospital outpatient departments while charging a $50 deductible for the same services in the offices of private radiologists and pathologists. This is further aggravated by Blue Shield, Medicare-65 plans (as in New Jersey and Pennsylvania) which pay both the deductible and the 20% coinsurance only to the hospital outpatient departments and not to the private specialists. The bias of the law extends also to those covered under part A only, for they receive supplemental payments for x-ray and pathology examinations only in hospital outpatient departments and not in physicians' offices. Thus by economic pressure resulting from legislative decree, the government is directing patient referral in the
EUSTRONGYLUS GIGAS.
Authors: G. W. MOREHOUSE
Journal: JAMA (1898)

John Hopkins of Centerburg, Ohio, age 58, weight 175 pounds, medium height, general health good, March 10, 1896, had an attack of severe renal colic on right side. He passed from his bladder, according to his own statement, a pint of blood during the first twenty-four hours. He had eight similar attacks during the month of March. Attending physicians at first diagnosticated renal calculus. March 27, he passed from the urethra a worm nearly a foot in length. Two more worms, four and seven inches long, respectively, were passed by April 1. Since this date, he states that he has expelled from his bladder fifty-five worms, from one inch to one foot long, with the addition of numerous flesh-like shreds, which he considers portions of additional worms, but which were probably blood coagula. He has not bled much since passing the first worm. He claims now to pass the parasites