tbuckley/cabot-search huggingface dataset:
Mortality Patterns—United States, 1989
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Procainamide-induced lupus syndrome in siblings
Authors: M. A. Novack
Journal: JAMA (1975)

THE FAMILIAL occurrence of systemic lupus erythematosus in man and experimental animals is a well-recognized phenomenon.<sup>1</sup>While the induction of the lupus syndrome by procainamide hydrochloride<sup>2,3</sup>has become commonplace, there have been no reports, to our knowledge, of procainamide-induced lupus in siblings. We are reporting the development of this drug-induced lupus syndrome in a man whose sister suffered a similar reaction ten years earlier. She was case 2 in a series of four reported inThe Journalin 1965.<sup>3</sup> <h3>Report of a Cas</h3> A 69-year-old man was admitted to St. Luke's Hospitals on July 9, 1974. He had enjoyed good health until two years prior to admission, when shortness of breath and swelling of ankles developed. Despite moderate congestive heart failure, he refused admission. He was treated with digoxin, furosemide, and an orally administered potassium supplement. His condition subsequently improved and all medications were discontinued four months
Serum Transaminase Changes in Severe Burns
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Determinants of Vancomycin Resistance and Death in Enterococcal Bacteremia
Journal: Annals of Internal Medicine (2001)

Summaries for Patients2 October 2001Determinants of Vancomycin Resistance and Death in Enterococcal BacteremiaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-7-200110020-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Enterococci (a bacteria) ordinarily live in the colon, but under certain circumstances they can spread to the bloodstream (enterococcal bacteremia) and cause potentially fatal infections. While most enterococci can be treated with many different antibiotics, about 20% of the enterococci found in patients in intensive care units are highly resistant to antibiotics.Why did the researchers do this particular study?The researchers wanted to determine the clinical situations associated with the presence of resistant enterococci, the effect of antibiotic resistance on survival, and the effect of appropriate antibiotic ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Determinants of Vancomycin Resistance and Mortality Rates in Enterococcal Bacteremia. A Prospective Multicenter Study.” It is in the 2 October 2001 issue of Annals of Internal Medicine (volume 135, pages 484-492). The authors are EN Vergis, MK Hayden, JW Chow, DR Snydman, MJ Zervos, PK Linden, MM Wagener, B Schmitt, and RR Muder.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDeterminants of Vancomycin Resistance and Mortality Rates in Enterococcal Bacteremia: A Prospective Multicenter Study Emanuel N. Vergis , Mary K. Hayden , Joseph W. Chow , David R. Snydman , Marcus J. Zervos , Peter K. Linden , Marilyn M. Wagener , Barbara Schmitt , and Robert R. Muder Metrics 2 October 2001Volume 135, Issue 7Page: I-43KeywordsAntibioticsBacteremiaBacteriaDeath ratesEnterococcus infectionsHospitalizationsImmunityInfectious diseasesVancomycinVancomycin resistance ePublished: 2 October 2001 Issue Published: 2 October 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Dichotomous Disservice
Authors: David H. Spodick
Journal: Annals of Internal Medicine (1997)

Letters1 December 1997Dichotomous DisserviceDavid H. Spodick, MD, DScDavid H. Spodick, MD, DScSt. Vincent Hospital; Worcester, MA 01604Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-11-199712010-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:“Dichotomy: Division into two parts, groups or classes esp. when these are sharply distinguished or opposed” [1]. Dr. Carlton's perceptive essay [2] makes a major point worthy of this well-known cardiologist and sophisticated thinker. However, I am at a loss as to why, out of the enormous world of medical publication, he has chosen one of my contributions [3] as one of only two examples of “dichotomous thinking.” That report, which successfully ended the dichotomous thinking concerning electrocardiographic distinction of anatomically transmural and non-transmural infarction, was anything but dichotomous. The S-T infarction mentioned in the title of ...References1. Webster's New World Dictionary. 2d College ed. New York: Simon & Schuster; 1980. Google Scholar2. Carleton RA. Dichotomous disservice? Ann Intern Med. 1997; 126:589-91. Google Scholar3. Spodick DH. Q-wave infarction versus S-T infarction. Nonspecificity of electrocardiographic criteria for differentiating transmural and nontransmural lesions. Am J Cardiol. 1983; 51:913-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: St. Vincent Hospital; Worcester, MA 01604 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1997Volume 127, Issue 11Page: 1044KeywordsElectrocardiographyInfarction Issue Published: 1 December 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract CT045: Hyleukin-7, a long-acting interleukin-7, increased absolute lymphocyte counts after subcutaneous and intramuscular administration in healthy subjects
Authors: Sang Won Lee, Donghoon Choi, MinKyu Heo, Eui-Cheol Shin, Su-Hyung Park, So Jeong Kim, Byung Ha Lee, Se Hwan Yang, Young Chul Sung, Howard Lee
Journal: Cancer Research (2019)

Abstract Higher lymphocyte counts predict lower mortality in patients with various oncologic malignancies. Interleukin-7 (IL-7), a homeostatic cytokine, plays a critical and non-redundant role in developing T-cells and maintaining immune functions after development. IL-7 is a potent T-cell amplifier, thereby contributing to immune reconstitution, which may result in clinical benefits. A randomized, double-blind, placebo-controlled, dose-escalation, Phase I study was conducted to assess the safety, tolerability, pharmacokinetic and biological properties of Hyleukin-7 (human IL-7 fused to hyFcTM) administered subcutaneously (SC) and intramuscularly (IM) to healthy volunteers. Ten subjects randomly received Hyleukin-7 or its matching placebo in an 8:2 ratio in each of three cohorts at 20 and 60 μg/kg SC and 60 μg/kg IM. Dose escalation and switch from SC to IM was determined on 28 days after study drug administration based on the safety and tolerability data. Subjects were followed up to 56 days after dose. Hyleukin-7 was well tolerated and no subject developed cytokine release syndrome. Injection site reactions were the most common treatment-emergent adverse events, which resolved spontaneously without treatment. Hyleukin-7 was slowly but steadily absorbed and its terminal half-life ranged 48-112 hours. Furthermore, Hyleukin-7 increased absolute lymphocyte counts (ALC) in a dose-dependent manner which lasted during the observed period of 56 days after dose. The mean maximum increase in ALC from baseline was seen 3 weeks after dose. IM Hyleukin-7 increased ALC greater than SC Hyleukin-7 did at the same dose (111.4% IM vs. 75.1% SC). In all of the doses, Hyleukin-7 markedly increased the numbers of all peripheral CD4+ and CD8+ lymphocyte subsets (i.e., naïve, EM, CM and TEMRA). These increases are attributed to enhanced expression of Ki-67. SC and IM Hyleukin-7 was safe and well-tolerated in a dose range of 20 to 60 μg/kg in healthy subjects. A single SC and IM dose of Hyleukin-7 increased ALC dose-dependently. The results of this study warrant further investigation of Hyleukin-7 as a potential immune-oncology therapeutics to treat patients with compromised T-cell immunity. Citation Format: Sang Won Lee, Donghoon Choi, MinKyu Heo, Eui-Cheol Shin, Su-Hyung Park, So Jeong Kim, Byung Ha Lee, Se Hwan Yang, Young Chul Sung, Howard Lee. Hyleukin-7, a long-acting interleukin-7, increased absolute lymphocyte counts after subcutaneous and intramuscular administration in healthy subjects [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT045.
METHEMOGLOBINEMIA
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thyroid function after mantle irradiation in Hodgkin's disease
Authors: R. E. Smith
Journal: JAMA (1981)

We studied the thyroid function of 64 patients with Hodgkin's disease who received mantle irradiation during the period 1966 to 1976. More than two thirds (44 of 64) had some thyroid dysfunction. Twenty had mild dysfunction manifested by an abnormal thyroid-stimulating hormone response to thyrotropin-releasing hormone. Twenty had what could be termed compensated hypothyroidism while four were overtly hypothyroid. The severity of dysfunction was not related to age, sex, or chemotherapy. We found, however, that decreased thyroid function was inversely proportional to the length of time between a diagnostic lymphangiogram and the radiation therapy. These results are consistent with the hypothesis that the iodine load of the lymphangiogram renders the thyroid gland more radiosensitive. Thyroxine suppression of the thyroid gland during the period from the lymphangiogram through the termination of radiation therapy is suggested as a means of avoiding thyroid injury. (<i>JAMA</i>1981;245:46-49)
Sporadic puerperal mastitis. An infection that need not interrupt lactation
Authors: B. R. Marshall
Journal: JAMA (1975)

Sporadic (nonepidemic) acute puerperal mastitis was diagnosed 65 times over a period of 26 months in 2.5% of mothers who elected to nurse their infants.<i>Staphylococcus aureus</i>was cultured from the milk of 23 of 48 infected breasts, but from only one breast of 19 normal mothers. Forty-one women with mastitis continued to nurse without difficulty for an average of 13 weeks, although mastitis recurred in four women. Three breast abscesses resulted from the 65 infections (4.6%). (<i>JAMA</i>233:1377-1379, 1975)
P05.42 The natural course of atypical meningioma after gross total resection without adjuvant treatment
Authors: H Yoo, B Gu, J Byun, Y Cho, S Hong, J Kim, C Kim, Y Kim
Journal: Neuro-Oncology (2018)

The optimal management of atypical meningioma after gross total resection remains unclear and controversial. After Simpson grade 1 resection, observation without adjuvant treatment has wide currency, while Simpson grade 4 resection, adjuvant treatment or closed observation recommended at least. In this study, the authors made a comparison with natural course of atypical meningioma after gross total resection without adjuvant treatment, especially in Simpson grade 2 resection. In this study, authors reviewed 179 cases with histological proven atypical meningioma(WHO grade II) managed in single hospital between June 1990 and December 2015. A total of 62 men and 117 women were included who underwent their first surgery in our institute. Patients variably underwent adjuvant radiation therapy according to individual surgeon practices. Outcomes including overall survival and recurrence rate were analyzed using Kaplan-Meier method. The average age of patients was 54.5 years. The median follow up time was 56 months. Simpson grade 1 resection without immediate postoperative adjuvant therapy was achieved in 97 patients of total 106 patients. 5-year local control rate was 82.9% and overall survival was 97.4%. 59 patients was treated with Simpson grade 2 resection and 56 patients was just under observation without adjuvant treatment. 5-year local control rate was 63.7% and overall survival was 95.2%. This study have performed to examine the need to adjuvant treatment for atypical meningioma after gross total resection. Patients who treated with Simpson grade 2 resection represent poor local control and shorter overall survial than Simpson grade 1 resection. The authors suggest that further adjuvant therapy should be considered even in groups of Simpson grade 2 resection, at least closed observation needed.
Cardiac arrest: signal of anesthetic mishap
Authors: L. D. Vandam
Journal: JAMA (1985)

"I was proceeding to apply more [chloroform] to the handkerchief, when her lips, which had been previously of good colour, became suddenly blanched, and she sputtered at the mouth, as if in epilepsy. I threw down the handkerchief, dashed cold water in her face, and gave her some internally, followed by brandy without, however, the least effect, not the slightest attempt at a rally being made. We laid her on the floor, opened a vein in her arm, and the jugular vein, but no blood flowed. The whole process of inhalation, operation, venesection, and death, could not, I should say, have occupied more than two minutes."<sup>1</sup>In 1848, thus wrote surgeon T. M. Meggison, who gave the anesthetic, while Mr Lloyd began to excise a toenail from the foot of Hannah Greener, a healthy girl of 15 years. After postmortem examination and the inquest, Sir John Fife, distinguished surgeon
Incorrect Data in: Managing an Acute Pain Crisis in a Patient With Advanced Cancer: “This Is as Much of a Crisis as a Code”
Authors: Steven Woolf
Journal: JAMA (2008)

conduct such studies are likely to assume that their work falls under this category.Conversely, public health and health services researchers might be confused to see the term applied to their work.Furthermore, using "clinical" in both terms perpetuates the tendency of the medical profession to view health research through the clinician's lens alone.Fiscella et al do include "organizational-and communityfocused" research within their definition of applied clinical research, but labeling health interventions outside the clinic as "clinical" research may be a forced fit.Pros and cons exist with other potential terms such as knowledge translation-the term discussed by Dr Graham and Ms Tetroe-but all of them are an improvement over the ambiguity of T2.Graham and Tetroe call attention to the excellent work of the Canadian Institutes of Health Research.Canadian investigators and institutions have played a leadership role not only in writing about the need for researchers to align their work with the information needs of end users 1 but also in making real commitments in programs and funding to facilitate T2 as a nation. 2The United States would do well to follow the Canadian example.T1 is among a group of clinical research movements that are attracting attention and resources but are ultimately unhelpful to patients without T2.Recently, politicians and industry have announced plans to channel millions of dollars per year into research on "comparative effectiveness" 3 and "personalized medicine" 4 while keeping funding for health services research threadbare. 5 Popular research initiatives address worthy questions: whether a treatment can be produced (T1), whether it improves health (evidence-based medicine), which treatment is best (comparative effectiveness), and which is best for an individual patient (personalized medicine).But the answers remain academic if the patient cannot obtain or use the intervention.Overcoming such obstacles so that the products of research benefit all those in need is itself a crucial research priority.
Bloodstream Infections in Hematological Cancer Patients Colonized By Multiresistant Bacteria: Final Results of a Multicentric Prospective Observational Seifem Study
Authors: Chiara Cattaneo, Roberta Di Blasi, Crisitina Skert, Anna Candoni, Bruno Martino, Maria Rosaria De Paolis, Mario Delia, Stelvio Ballanti, Francesco Marchesi, Valentina Mancini, Francesco Mazziotta, Simone Cesaro, Franco Aversa, Rosa Fanci, Gianpaolo Nadali, Anna Chierichini, Luca Facchini, Mauro Picardi, Domenico Russo, Vincenza Orlando, Enrico Maria Trecarichi, Mario Tumbarello, Giuseppe Rossi, Livio Pagano
Journal: Blood (2016)
Upper gastrointestinal tumors
Authors: Frank Vleggaar, Peter Siersema
Journal: Endoscopy (2014)

Endoscopy Essentials Reviews in the Endoscopy Essentials series cite publications from the past year which, in the authors’ opinion, reflect the state-of-the-art in endoscopy. Alongside a short summary of each paper, authors explain why they consider their selected articles to be of importance.
Changing Careers
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ureteral ectopia, hydrocolpos, and uterus didelphys
Authors: H. M. Constantian
Journal: JAMA (1966)

THE INCIDENCE of some anomalies of the genitourinary tract is relatively rare. The coexistence of several in a 6-year-old child warrants this report. <h3>Report of a Case</h3> A 6-year-old white girl was admitted to the Worcester Hahnemann Hospital on March 5, 1962, with dribbling after voiding and a bulging membrane at the introitus. Three months prior to admission, a greenish, mucous vaginal discharge was found on the girl's clothing for one day. Following this, the child dribbled between voidings and her clothing was constantly damp. With coughing, the dribbling became worse. Although voiding at normal intervals, she had urgency and dysuria at times. Difficulty in initiating micturition was noted. Nocturia occurred accasionally. The history was noncontributory. Results of physical examination were normal except that a bluish-gray membrane, 2 cm in diameter, bulged from the vaginal orifice. With coughing, the membrane ballooned out and a trickle of clear fluid was seen.
Statin therapy Prescribing patterns for primary prevention of Cardiovascular disease in patients with type 2 Diabetes Mellitus receiving primary care at the Tamale Teaching Hospital (TTH) in Northern
Authors: Martin Malick
Journal: Clinical Cardiology and Cardiovascular Interventions (2020)

Studies have shown that controlling these cardiovascular risk factors helps in preventing and slowing cardiovascular events in diabetes [7].Management of cardiovascular risks in type 2 diabetics is usually grouped into two categories: primary prevention and secondary prevention.Primary prevention refers to those patients without documented atherosclerotic cardiovascular disease (ASCVD) whilst secondary prevention refers to those with documented ASCVD [8].Statins inhibit the enzyme 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, which is the rate-limiting step in cholesterol synthesis in the body.Statins reduce