tbuckley/cabot-search huggingface dataset:
Circadian Rhythms
Authors: G. G. Liddle
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Biological timing does not begin and end with a phrase, nor is it a simple mechanism. In algae a synthetic photoperiodism can be established by exposing them to regular periods of light and darkness, which will continue for weeks even in enucleate fragments. This is a phenomenon of intracellular metabolism in Acetabularia, as Brachet reports in detail, where DNA is involved in the biological clock (<i>Endeavour</i><b>24</b>:155, 1965). His experiments show that the nucleus of the cell supplies something essential, and that there is a delicate interaction between the messenger RNA formed in the nucleus and the chloroplasts. The normal rhythm of multiplication of the chloroplasts is slowed after removal of the nucleus. "Circadian" if you like, but let's start the rhythms off correctly, within the cell. Biological clocks in hamsters have been found geared to something close to lunar time periods, and influences of light
Breaking the Cycle
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multistate Outbreaks of Salmonella Serotype Poona Infections Associated With Eating Cantaloupe From Mexico--United States and Canada, 2000-2002
Journal: JAMA (2002)

Three multistate outbreaks of Salmonella serotype Poona infections associated with eating cantaloupe imported from Mexico occurred in the spring of consecutive years during 2000-2002. In each outbreak, the isolates had indistinguishable pulsed-field gel electrophoresis (PFGE) patterns; the PFGE patterns observed in the 2000 and 2002 outbreaks were indistinguishable, but the pattern from 2001 was unique among them. Outbreaks were identified first by the California Department of Health Services (2000 and 2001) and the Washington State Department of Health (2002) and involved residents of 12 states and Canada. This report describes the investigations, which led ultimately to an import alert on cantaloupes from Mexico. To limit the potential for cantaloupe contamination, the Food and Drug Administration (FDA) continues to work with the Mexican government on a food-safety program for the production, packing, and shipping of fresh cantaloupes.
Abstract 3700: Investigating the therapeutic potential of parthenolide for hematopoietic neoplasms in dogs
Authors: Lisa J. Schlein, Barbara Rose, Aubree Peterson, Douglas Thamm
Journal: Cancer Research (2019)

Abstract The purpose of this research is to explore the therapeutic potential of parthenolide (PTL) to treat various hematopoietic neoplasms in dogs; additionally, some dog breeds are enriched for development of mast cell neoplasia and histiocytic sarcoma, providing translational study populations for rare and deadly human diseases. Growth inhibition assays were performed using a panel of canine mast cell, histiocytic sarcoma, lymphoma, and leukemia cell lines, with PTL alone or in combination with redox-perturbing standard-of-care therapeutics. Cell death was assessed using flow cytometry. Immunofluorescence and immunoblotting were used to assess NFκB localization and phosphorylation, respectively. All immortalized canine cell lines evaluated are sensitive to PTL therapy and undergo dose-dependent apoptosis following exposure to drug. PTL exposure leads to inhibition of NFκB, as evidenced by immunofluorescent nuclear exclusion and decreased p65 phosphorylation. Preliminary studies indicate that some standard-of-care therapeutics synergize with PTL. These initial studies show that PTL is a promising therapeutic for hematopoietic neoplasms in dogs. Murine modeling and investigation of redox perturbance are underway and will further investigate PTL’s potential in the clinical setting. Citation Format: Lisa J. Schlein, Barbara Rose, Aubree Peterson, Douglas Thamm. Investigating the therapeutic potential of parthenolide for hematopoietic neoplasms in dogs [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3700.
Preliminary Results from a Phase Ib Study of Isatuximab in Combination with Pomalidomide and Dexamethasone in Relapsed and Refractory Multiple Myeloma
Authors: Paul G. Richardson, Joseph Mikhael, Saad Z Usmani, Noopur Raje, William Bensinger, Frank Campana, Lei Gao, Franck Dubin, Claudine Wack, Kenneth C. Anderson
Journal: Blood (2016)
Propranolol withdrawal and myocardial infarction
Authors: A. Flach
Journal: JAMA (1981)

<h3>In Reply.—</h3> Vickery and Fries correctly observe that because of large variations in physician visits among any group of persons or families, it is difficult to show a statistically significant impact on physician visits with any intervention. The correct conclusion from our study is that the book alone, or the book plus the financial incentive, does not increase or decrease use of physicians by 21% or more in a prepaid health plan. We calculate that future studies will need nearly 2,500 families to reliably detect a true 7.5% reduction because of the book's effect if populations with similar variability in use are studied. We agree that firm conclusions about increases or decreases of less magnitude than 21% should not be made from this study because of large variances relative to the 700 families in the study. This includes the 7.5% greater decrease among the experimental groups in this study. Since
Medical Journals and the Popular Media
Authors: International Committee of Medical Journal Editors
Journal: New England Journal of Medicine (1993)

The following statement was approved by the International Committee of Medical Journal Editors* at its January 1993 meeting in London.The public's interest in news of medical research has led the popular media to compete vigorously to get information about research as soon as possible. Researchers and institutions sometimes encourage the reporting of research in the popular media before full publication in a scientific journal by holding a press conference or giving interviews.The public is entitled to important medical information without unreasonable delay, and editors have a responsibility to do their part in this process. Doctors need to have . . .
Helmholtz's Treatise on Physiological Optics. Translated from the Third German edition.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dictionary
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Articular Sporotrichosis
Authors: RONALD WEITZNER
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 September 1977Articular SporotrichosisRONALD WEITZNER, M.D., ELLY MAK, M.D., YONGSUK LERTRATANAKUL, M.D.RONALD WEITZNER, M.D.Search for more papers by this author, ELLY MAK, M.D.Search for more papers by this author, YONGSUK LERTRATANAKUL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-3-382_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently Grout, Brewer, and Tompkins (Ann Intern Med 86:294-297, 1977) underscored the importance of considering the diagnosis of articular sporotrichosis, apparently the predominant fungal arthropathy in the midwestern United States, in patients with chronic synovitis. We recently treated a patient with articular sporotrichosis misdiagnosed as rheumatoid arthritis for more than 3 years. The patient has now been disease-free for more than 2 years after treatment with systemic and intra-articular amphotericin B. In that the number of patients thus treated (1-3) is small, this observation may be of interest.A 49-year-old tree cutter in 1970 noted painful wrists...References1. LEVINSKY W: Sporotrichial arthritis. Report of a case mimicking gout. Arch Intern Med 129:118-119, 1972 CrossrefMedlineGoogle Scholar2. MARROCCOTIHENGOODNOUGH GWC: Granulomatous synovitis and osteitis caused by Sporothrix schenckii. Am J Clin Pathol 64:345-350, 1975 CrossrefMedlineGoogle Scholar3. LATAPÍ F: Griseofulvin in the treatment of some deep mycoses. Arch Dermatol 81:841-848, 1960 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rheumatology Section Veterans Administration Hospital Hines, IL 60141 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOther MycosesOTHER FUNGAL ARTHRITIDESFungal arthritis.SporotrichosisSporotrichosis of the Knee: A Case ReportSporotrichal arthritis presenting as granulomatous myositisFungal arthritis. III. Sporotrichal arthritis 1 September 1977Volume 87, Issue 3Page: 382-382KeywordsAmphotericinRheumatoid arthritisSporotrichosis Issue Published: 1 September 1977 PDF DownloadLoading ...
What's new in the other general journals
Authors: Alison Tonks
Journal: BMJ (2006)

Sleep deprivation is bad for performance, but being woken up is worse. In a laboratory experiment, adult volunteers performing a series of random adding tests scored lower in the three minutes after waking than they did at any time over the next 24 hours. One minute after waking, their scores were only 65% of their best, significantly worse than all other test scores during the experiment, including the test done after a whole night without sleep (P ≤ 0.01). After 20-60 minutes awake, the volunteers had bounced back to over 80% of their peak performance. Credit JAMA The experiment was small but carefully done. The nine healthy volunteers had no caffeine, alcohol, nicotine, or drugs (recreational or medicinal) for three weeks before the study. For the same period they logged a regular eight hours' sleep every night. The results suggest that cognitive performance is worst just after waking, which has obvious implications for on-call doctors, truck drivers, soldiers, and others who are woken from sleep to do complex tasks more or less immediately. JAMA 2006; 295: 163-4 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Diagnosing pulmonary embolism can be a complicated, multistage process. In an attempt to simplify it, Dutch doctors developed a new more straightforward approach. Firstly, decide whether pulmonary embolism is likely or unlikely using a simplified version of the Well's rule. If pulmonary embolism is unlikely, do a d-dimer test. If that's negative, withhold anticoagulants. For everyone else, go straight for computed tomography and rely on the results to make a treatment decision. It seems to work. In a large trial of 3306 patients with suspected pulmonary embolism, treatment was withheld from 1028 who were classed as “unlikely” to have embolism and had a negative d-dimer test result. Over the next three months, only five of them (0.5%, 95% CI 0.2% to 1.1%) developed venous thromboembolism. Treatment was … [1]: {openurl}?query=rft.jtitle%253DJAMA%26rft.stitle%253DJAMA%26rft.issn%253D0002-9955%26rft.aulast%253DWertz%26rft.auinit1%253DA.%2BT.%26rft.volume%253D295%26rft.issue%253D2%26rft.spage%253D163%26rft.epage%253D164%26rft.atitle%253DEffects%2Bof%2BSleep%2BInertia%2Bon%2BCognition%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjama.295.2.163%26rft_id%253Dinfo%253Apmid%252F16403927%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/jama.295.2.163&link_type=DOI [3]: /lookup/external-ref?access_num=16403927&link_type=MED&atom=%2Fbmj%2F332%2F7534%2F163.atom [4]: /lookup/external-ref?access_num=000234544300020&link_type=ISI
Abstract 11814: Platelet Distribution Width as a Novel Prognostic Marker in Chronic Heart Failure
Authors: Mitsunori Ishino, Takanori Arimoto, Harutoshi Tamura, Shunsuke Netsu, Yoichiro Otaki, Akira Funayama, Hiromasa Hasegawa, Shintaro Honda, Satoshi Nishiyama, Hiroki Takahashi, Tetsuro Shishido, Takehiko Miyashita, Takuya Miyamoto, Tetsu Watanabe, Isao Kubota
Journal: Circulation (2011)

Background: Chronic heart failure (CHF) is associated with increased risk of cardiovascular thromboembolism and sudden death. This may be related to abnormalities of thrombogenesis and platelet act...
Thyrotoxicosis with painless goiter may recur or develop into hypothyroidism
Authors: W. Check
Journal: JAMA (1978)

About five years ago, reports appeared describing a form of thyrotoxicosis with painless goiter and low radioactive iodine uptake (RAIU) that appeared to resolve spontaneously in two to six months. The initial interpretation was that this condition is a variant of subacute thyroiditis, since the only apparent difference between the two was that in the latter condition the goiter is painful. However, biopsy studies subsequently showed that patients with transient painless goiter and thyrotoxicosis always have a lymphocytic inflammation rather than the granulomatous lesion found in subacute thyroiditis (<i>JAMA</i>240:1520-1521, 1978). New data presented at the recent meeting of the American Thyroid Association now show that there is another major difference: The newly described painless form does not resolve completely, as does subacute thyroiditis, but may recur over a period of years. According to Thomas F. Nikolai, MD, staff physician in the endocrinology section of the Marshfield (Wisconsin) Clinic and
Pediatric Trauma: Getting Triage Right
Authors: Carla Di Scala
Journal: JAMA (1990)

<h3>To the Editor.—</h3> I enjoyed reading the article entitled "Evaluation of the Pediatric Trauma Score,"<sup>1</sup>but I am having some problems with the authors' conclusions in relation to overtriaging and undertriaging of the two severity scores. While I agree that overtriaging (Pediatric Trauma Score more responsible than the Revised Trauma Score) is a serious problem, especially in these days of cost containment, I also think that undertriaging (Revised Trauma Score more responsible than the Pediatric Trauma Score) is an even more serious problem, given the consequences of inadequate medical care. There is more to the cost of trauma than just direct medical costs. I was also puzzled by the extolling of the virtues of a triaging system with fewer parameters after a paragraph that seems to indicate that the Revised Trauma Score's undertriage rate could be improved by "inclusion of specific injury criteria and evidence of high impact," thereby
Neonate with abdominal calcifications
Authors: C. Beetlestone
Journal: JAMA (1978)

<h3>History</h3> Progressive tympanic abdominal distension with markedly reduced chest excursions and concomitant respiratory distress developed in a neonate who was delivered by cesarean section after a prolonged labor. He became increasingly pale and shocked. He died within hours of birth. Figures 1 and 2 are flat and upright views of the abdomen without contrast medium. <h3>Diagnosis</h3> Spontaneous rupture of the gut with tension pyopneumoperitoneum in a neonate. <h3>Comment</h3> The erect film of the chest and abdomen (Fig 1) shows bilateral collapsed lungs. A long air-fluid level bisects the horizontal midplane of the distended abdomen. Air-filled bowel loops float in the midline near the top and above the fluid level. The intraperitoneal air seems to be draped over the liver and spleen, which are displaced downward and medially, leaving bilateral radiolucencies in a saddlebag configuration. The falciform ligament is outlined by air. The supine film (Fig 2) shows a large, centrally
Small-bowel endoscopy
Authors: A. May
Journal: Endoscopy (2009)

There is no doubt that capsule endoscopy had been a major breakthrough in the field of small-bowel endoscopy. But capsule endoscopy is a pure diagnostic tool that does not give the option of obtaining histologic samples or carrying out endoscopic treatments. Nevertheless, it has proven its value within the past years, particularly in patients with suspected mid-gastrointestinal bleeding [2] [3]. One of the reasons for this is that capsule endoscopy allows, in most cases, the endoscopic visualization of the entire small bowel. However, there are still some limitations that have to be faced: a unidirectional camera, the inability to insufflate air and to suck fluid, and the lack of control of the transit through the small bowel. The question of how much of the small bowel cannot be seen adequately remains unanswered.
Results of the X-PECT study: A phase III randomized double-blind, placebo-controlled study of perifosine plus capecitabine (P-CAP) versus placebo plus capecitabine (CAP) in patients (pts) with refractory metastatic colorectal cancer (mCRC).
Authors: Johanna C. Bendell, Thomas J. Ervin, Neil N. Senzer, Donald A. Richards, Irfan Firdaus, A. Craig Lockhart, Allen Lee Cohn, Mansoor N. Saleh, Lesa R. Gardner, Peter Sportelli, Cathy Eng
Journal: Journal of Clinical Oncology (2012)

LBA3501 Background: Perifosine (P) is an oral, synthetic alkylphospholipid that inhibits or modifies signal transduction pathways including AKT, NFkB and JNK. A randomized phase II study examined P-CAP vs. CAP in pts with 2nd or 3rd line mCRC. This study showed improvement in mTTP (HR 0.254 [0.117, 0.555]) and mOS (HR 0.370 [0.180,0.763]). Based on these results, a randomized phase III study of P-CAP vs. CAP with a primary endpoint of overall survival (OS) in pts with refractory mCRC was initiated. Methods: The study was a prospective, randomized, double-blind, placebo-controlled randomized phase III trial. Eligible pts had mCRC which was refractory to all standard therapies. Pts randomized 1:1 to Arm A = P-CAP (P 50 mg PO QD + CAP 1000 mg/m 2 PO BID d1-14) or Arm B = CAP (placebo + CAP 1000 mg/m2 PO BID d 1-14). Cycles were 21 days. Baseline tumor block collection and a biomarker cohort of pts with pre- and on-treatment tumor and blood samples were performed. Results: Between 3/31/10 and 8/12/11, 468 pts were randomized, 234 pts were in each arm. Baseline demographics were balanced between the arms: age &lt; 65y (A: 65%, B: 58.5%), male (A: 57.7%, B: 53.0%), ECOG PS 0 (A: 39.7%, B: 39.7%), K-ras mutant (A: 50.4%, B: 51.3%), and median number of prior therapies (A: 4, B: 4). As of 3/19/12, median follow up was 6.6 months. Median overall survival: Arm A = 6.4 mo, Arm B = 6.8 mo, HR 1.111 [0.905,1.365], p = 0.315. Median overall survival for K-ras WT pts: Arm A = 6.6 mo, Arm B = 6.8 mo, HR 1.020 [0.763,1.365], p = 0.894; K-ras mutant pts: Arm A = 5.4 mo, Arm B = 6.9 mo HR 1.192 [0.890,1.596], p = 0.238. Conclusions: Despite promising randomized phase II data, this phase III study shows no benefit in overall survival adding perifosine to capecitabine in the refractory colorectal cancer setting. Response rate, progression free survival, and safety data will be presented. Biomarker analysis is pending to see if subgroups of patients may have potential benefit.
URINARY OUTPUT IN PROGNOSIS OF ACUTE RENAL FAILURE
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal