tbuckley/cabot-search huggingface dataset:
Educational Programs in Areas Allied to Medicine
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ECONOMIC FACTORS IN GRADUATE MEDICAL EDUCATION
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel Blockers vs Angiotensin-Converting Enzyme Inhibitors
Authors: S. A. Yarows
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgical Lesions of Diabetic Feet
Journal: New England Journal of Medicine (1955)

A STUDY of the frequency and the cost, both financial and in terms of future disability, resulting from surgical lesions of the feet in diabetic patients was undertaken in the hope that the information thus obtained might stimulate interest in and implement measures to prevent these lesions or reduce their cost. The Committee on Diabetes of the Massachusetts Medical Society proposed in 1953 that certain hospitals in Boston equipped with a resident staff assess the frequency of these cases by recording all diabetic patients actually in the hospital wards and seen by surgeons because of surgical lesions of the feet. . . .
Testing Their Metal
Authors: Brandy E. Fisher
Journal: Environmental Health Perspectives (1999)

Metals continually rank at the top of the U.S. Environmental Protection Agency's annual list of agents that pose the greatest hazard to the people of the United States. Metals aren't going away, either. They do not biodegrade, and they often concentrate in human and animal cells and tissue. Many metals are known human and animal carcinogens, while many others are suspected to play a role in cancer. Little is known, however, about the mechanisms by which metals cause cancer.
Value of Antidepressant Drugs Over Other Therapy Questioned
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE NEW YORK STATE MEDICAL ASSOCIATION.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosing Adult Attention Deficit Hyperactivity Disorder: Are Late Onset and Subthreshold Diagnoses Valid?
Authors: Stephen Faraone
Journal: American Journal of Psychiatry (2006)

Objective: Diagnosing attention deficit hyperactivity disorder (ADHD) in adults is difficult when diagnosticians cannot establish an onset before the DSM-IV criterion of age 7 or if the number of symptoms recalled does not achieve DSM’s diagnosis threshold. Method: The authors addressed the validity of DSM-IV’s age-at-onset and symptom threshold criteria by comparing four groups of adults: 127 subjects with full ADHD who met all DSM-IV criteria for childhood-onset ADHD, 79 subjects with late-onset ADHD who met all criteria except the age-at-onset criterion, 41 subjects with subthreshold ADHD who did not meet full symptom criteria for ADHD, and 123 subjects without ADHD who did not meet any criteria. The authors hypothesized that subjects with late-onset and subthreshold ADHD would show patterns of psychiatric comorbidity, functional impairment, and familial transmission similar to those seen in subjects with full ADHD. Results: Subjects with late-onset and full ADHD had similar patterns of psychiatric comorbidity, functional impairment, and familial transmission. Most children with late onset of ADHD (83%) were younger than 12. Subthreshold ADHD was milder and showed a different pattern of familial transmission than the other forms of ADHD. Conclusions: The data about the clinical features of probands and the pattern of transmission of ADHD among relatives found little evidence for the validity of subthreshold ADHD among such subjects, who reported a lifetime history of some symptoms that never met DSM-IV’s threshold for diagnosis. In contrast, the results suggested that late-onset adult ADHD is valid and that DSM-IV’s age-at-onset criterion is too stringent.
Prevalence and acquisition of viral hepatitis A, B, and C in patients undergoing liver transplantation (LT) . Hepatology and Liver Transplantation Programs, Cedars-Sinai Medical Center/UCLA, Los Angeles, CA and Abbott Laboratories, Abbott Park, IL
Journal: Hepatology (1995)

Human immunodeficiency virus (HIV) is a major health problem in the United States, with an estimated 1 million infected people. Approximately two thirds of the patients with acquired immunodeficiency syndrome (AIDS) have hepatomegaly and abnormal liver function tests.35 A subset of these patients develops disease of the biliary system. Opportunistic infection of the bile ducts in patients with AIDS was first described in 1983 by Pitlik and colleagues30, 31 and Guarda and colleagues.20 Each independently reported on biliary cryptosporidiosis associated with extrahepatic obstruction. In 1984, Blumberg and co-workers6 reported on a patient with AIDS with acalculous cholecystitis who had both Cryptosporidium and cytomegalovirus found in the gallbladder. Margulis and associates29 described the first series of AIDS patients with biliary obstruction owing to benign strictures. The patients had involvement of the biliary tree with either Cryptosporidium or cytomegalovirus. In 1987, Schneiderman and associates34 described eight patients with the endoscopic appearance of papillary stenosis and associated intraextrahepatic sclerosing cholangitis. Cello10 in 1989 described 20 patients with markedly abnormal cholangiograms. He identified four patterns of cholangiographic abnormalities and reported on the short-term efficacy of sphincterotomy. By 1995, Cello and Chan12 had reported on the long-term follow-up of patients with AIDS-related cholangitis. Aside from cytomegalovirus and Cryptosporidium, other causes of AIDS-related cholangitis have been discovered. Pol and colleagues32 in 1992 described a patient with previously unexplained AIDS-related cholangitis who was subsequently discovered to have Enterocytozoon bieneusi. Benator and co-workers3 reported on a patient with acalculous cholecystitis secondary to Isospora belli.
Effect of antibiotic treatment against chlamydia pneumoniae with roxithromycin on neointima proliferation after coronary stent placement Franz-Josef Neumann, Adnan Kastrati, Thomas Miethke, Gisela Pogatsa-Murray, Christian Valina, Julinda Mehilli, Albert Sch�mig. 1. Med. Klinik der Technischen Universitaet, Muenchen, Germany, Institut f�r Medizinische Mikrobiologie der Technischen Universitaet, Muenchen, Germany
Journal: Journal of the American College of Cardiology (2001)
Clinical Neurology
Authors: Frank R. Freemon
Journal: JAMA (1972)

The second edition of Elliott's textbook of neurology is 62 pages shorter than the first edition. The book consists of 22 chapters, 7 on pathophysiology of neurological systems, 4 on the evaluation of certain neurological symptoms (headaches, seizures) and 11 on diseases grouped by etiology. This organizational format produces considerable repetition; for example, the symptoms of cerebellar dysfunction are described in the chapter on the motor system and are recapitulated in cerebellar sections of the chapters on neoplastic, developmental, degenerative, and nutritional disorders. The book is up to date; it includes a section on the neurological complications of marihuana use. Each chapter is followed by a list of 50 to 100 recent and, in general, well-chosen references. Occasionally Elliott describes the results of a published work in detail, even giving the author's name, but then he fails to include the work in the reference list. Other minor irritations include the
Radiotherapy with moving-strip technique for testicular tumors metastatic to the lungs
Authors: N. Simon
Journal: JAMA (1966)

In two long-surviving patients with metastatic testicular tumors, the entire thorax was treated using moving-strip radiation. In this method, a narrow field is treated to a high dose each day, and the field is moved on the patient each succeeding treatment day until the whole volume has been irradiated. The patients tolerated the treatments unusually well, but radiation damage to the lungs developed, mild in the patient surviving 3 1/2 years, and more severe in the other. The histological diagnosis of the primary testis tumor is not a certain guide to radiosensitivity or histological type of the pulmonary metastases. Therefore, we advocate a test dose of radiation to a small lung metastasis to be assured of its radiosensitivity before embarking on moving-strip therapy.
Role of nitric oxide in the hepatic efflux of glutathione in endotoxemic rats . Departments of Biochemistry and Surgery*, Osaka City University Medical School, Osaka
Journal: Hepatology (1995)

Performance of laboratory-scale aerobic and anaerobic systems treating food-processing wastewater was investigated. The results obtained showed that BOD and COD of wastewater discharged from a potato-chips factory can be reduced by 86% and 82% using UASB reactor at an organic loading rate (OLR) of 2.9 kg BOD/m3d and a hydraulic retention time (HRT) of 18 hr. Corresponding results for an activated sludge system, operated at an OLR of 8.9 kg BOD/m3-d with a HRT of 6hr were 86% and 84%, respectively.Treatment of confectionery wastewater using UASB at a HRT of 12hr and an OLR of 4.4 kg BOD/m3.d gave satisfactory results. COD and BOD removals were 92.4% and 91.5%, respectively. The use of completely activated sludge system at a HRT of 6 hr and ORL of 8.4 kg BOD/m3.d gave lower results as compared to UASB reactor. However, characteristics of the effluents produced using, the two systems were in agreement with the standards regulating discharge of industrial wastewater into the sewerage system. Based on the technical and economic evaluation of the results, engineering designs were made for the selected systems.
The proportion of xanthine oxidase activity of total xanthine oxidoreductase activity in situ remains constant in rat liver under various (patho)physiological conditions
Authors: W Frederiks
Journal: Hepatology (1996)

Activity of xanthine oxidoreductase (total xanthine dehydrogenase plus xanthine oxidase) and xanthine oxidase was determined cytophotometrically in periportal and pericentral areas of livers of rats under various (patho)physiological conditions that are known to affect the content of reduced glutathione. For this purpose, rats were either normally fed or fasted for 24 hours, fasted for 24 hours, and treated with diethylmaleate that depleted glutathione or treated by in vivo ischemia for 2 hours in the livers. Xanthine oxidoreductase activity was shown histochemically with the use of a tetrazolium salt procedure, and xanthine oxidase activity was localized with a cerium- diaminobenzidine-cobalt-hydrogen peroxide technique in unfixed cryostat sections of the livers. Cytophotometric measurements showed that total xanthine oxidoreductase activity was decreased after fasting and ischemia, whereas only ischemia caused reduced xanthine oxidase activity. Moreover, the percentage of xanthine oxidase of total xanthine oxidoreductase activity was constant in both periportal and pericentral areas at the level of approximately 4% in normally fed and 24-hour fasted and diethylmaleate-treated rats. Ischemia reduced this percentage in both areas of the liver to 2%. It was concluded that the amount of endogenous reduced glutathione did not affect the percentage of xanthine oxidase. The low percentage of xanthine oxidase as determined in the present in situ histochemical study indicates that in vivo the percentage oxidase in rat liver is lower than is assumed on the basis of biochemical assays in liver homogenates even after strictly controlled homogenization procedures. Apparently, conversion of xanthine dehydrogenase into xanthine oxidase may occur in vitro to yield percentages of xanthine oxidase of 10%-20% as are reported in the literature. The latter increase in the percentage of xanthine oxidase may be caused by changes in the local environment of the enzymes, which is left completely intact in histochemical assays. The finding of this low percentage of xanthine oxidase further stresses that the main function of xanthine oxidoreductase in the liver is not the production of superoxide anion radicals and/or hydrogen peroxide but rather the metabolism of xanthine to uric acid, which can act as a potent antioxidant. (Hepatology 1996 Nov;24(5):1179-84)
Abstract 2283: A novel GUCY2C - CD3 bispecific engages T cells to induce cytotoxicity in gastrointestinal tumors
Authors: Divya Mathur, Adam Root, Bozena Bugaj-Gaweda, Xingzhi Tan, Wei Fang, Stephanie Bisulco, Jonathan Golas, Diane Fernandez, Jessica Kearney, Eric Upeslacis, Johnny Yao, Edward Rosfjord, Chad Stevens, Keith Kobylarz, Lindsay King, Jatin Narula, Kerry Kelleher, David Schaer, Cris Kamperschroer, Bernard Buetow, Cynthia Rohde, Allison Moreau, Gilbert Wong, Puja Sapra
Journal: Cancer Research (2020)

Abstract Gastrointestinal malignancies, including colorectal cancer (CRC) remain an area of high unmet need. Here we demonstrate tumor selective and potent in vitro and in vivo efficacy with PF-07062119, a novel T cell engaging CD3 bispecific against tumors expressing the Guanylyl Cyclase C (GUCY2C) receptor, a target expressed in more than 90% of CRC, and in other gastrointestinal cancers. Additionally, to address immune evasion mechanisms, combinations of the GUCY2C-CD3 bispecific are explored with immune checkpoint blockade therapy, as well as with chemotherapeutic and anti-angiogenic agents that could enhance immune infiltration into tumors. Our preclinical in vivo data demonstrate that GUCY2C-positive tumors can be targeted with an anti-GUCY2C/anti-CD3ϵ bispecific, with selective drug biodistribution to tumors. PF-07062119 showed potent T cell mediated anti-tumor activity in several human xenograft models of CRC, using adoptive transfer of human T cells, including those with KRAS and BRAF mutations, as well as in models with syngeneic tumors in immunocompetent human CD3 transgenic mice. PF-07062119 activity was further enhanced when combined with anti PD-1/PD-L1 treatment or in combination with chemotherapy or anti-angiogenic therapy. A combination of immunohistochemistry, flow cytometry and CyTOF analyses was used to demonstrate the mechanism of action of PF-07062119 in single agent and combination studies in vivo. Toxicity and pharmacokinetic studies were done in cynomolgus macaques and indicated a monitorable and manageable toxicity profile. These data highlight the potential for PF-07062119 to demonstrate efficacy and improve patient outcomes in CRC and other gastrointestinal malignancies. A clinical Phase I study has been initiated in patients with CRC, gastric and esophageal adenocarcinomas (NCT04171141). Citation Format: Divya Mathur, Adam Root, Bozena Bugaj-Gaweda, Xingzhi Tan, Wei Fang, Stephanie Bisulco, Jonathan Golas, Diane Fernandez, Jessica Kearney, Eric Upeslacis, Johnny Yao, Edward Rosfjord, Chad Stevens, Keith Kobylarz, Lindsay King, Jatin Narula, Kerry Kelleher, David Schaer, Cris Kamperschroer, Bernard Buetow, Cynthia Rohde, Allison Moreau, Gilbert Wong, Puja Sapra. A novel GUCY2C - CD3 bispecific engages T cells to induce cytotoxicity in gastrointestinal tumors [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2283.
Melanin Pigmentation and Its Endocrine Control
Authors: Stanley Deutsch, Herbert Mescon
Journal: New England Journal of Medicine (1957)

Evidence of a Pituitary Role in Melanin Pigmentation in ManAfter the work with lower vertebrates a number of investigators attempted to elucidate the physiologic role of MSH in vertebrates with no melanophores. Several lines of evidence have been presented strongly suggesting that a pituitary hormone plays a part in melanin pigmentation in man.Ehrhardt44 and Dietel45 demonstrated the presence of a melanophore-expanding substance in the urine of normal men and women. Jores and Glogner46 and Collin and Drouet47 claimed that there was an increased output of MSH in people with basophil adenomas of the pituitary gland, hyperthyroidism, migraine and . . .
Chronic infiltrates of lung associated with dyspnea
Authors: M. A. Weiner
Journal: JAMA (1968)

Dr. Reginald E. Greene: The patient is a 51-year-old white man who entered the Massachusetts General Hospital because of shortness of breath on exertion. He had had this symptom for one year. He had been in his usual excellent state of health, except for chronic postnasal drip, until 14 months previously, when an upper-respiratory tract infection with cough and nasal crusting developed. The cough increased and was occasionally productive of yellow sputum; there was no hemoptysis. Roentgenograms obtained nine months before his admission showed bilateral pulmonary infiltrates, whereas three years previously the roentgenogram of the chest had been normal. He was admitted to another hospital where bronchoscopy, cytologic study, and sputum examination for acid-fast bacilli were negative. His symptoms persisted, and a few months later bronchoscopy was performed to remove secretions. This relieved the cough, which almost disappeared. A decreased exercise tolerance developed which was associated with dyspnea and fatigability.