tbuckley/cabot-search huggingface dataset:
The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
Authors: Nicole E. Scharping, Ashley V. Menk, Rebecca S. Moreci, Ryan D. Whetstone, Rebekah E. Dadey, Simon C. Watkins, Robert L. Ferris, Greg M. Delgoffe
Journal: Immunity (2016)
<i>QuickStats</i>: Percentage of Nonfatal Injuries Among Males and Females,* by Place of Occurrence†<sup>,</sup>§ —National Health Interview Survey,¶ United States, 2012–2014
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

With 95% confidence intervals as error bars.† Respondents were asked, "Where were you when the injury/poisoning happened
Prevention of cardiac necrosis by amiloride
Authors: H. Selye
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract MP16: Prevalence of Dyslipidemia Patterns among US Hispanics: Results from the Hispanic Community Health Study / Study of Latinos
Authors: Carlos J Rodriguez, Katrina Swett, Sylvia Wassertheil-Smoller, Martha Daviglus, Robert Kaplan, Linda C Gallo, Aida L Giachello, Hector M Gonzalez, Neil Schneiderman, Gregory A Talavera
Journal: Circulation (2013)

Background: Prevalence and determinants of dyslipidemia among Hispanics/Latinos are not well known. Methods: Lipid and lipoprotein data from the HCHS/SOL -- a population-based cohort study of 16,415 US Hispanic/Latino participants, ages 18-74, from Cuban, Dominican, Mexican, Puerto Rican, and Central and South American backgrounds -- were used. Criteria for dyslipidemia are based on National Cholesterol Education Program Adult Treatment Panel III guidelines as low density lipoprotein-cholesterol (LDL-C) &gt;130 mg/dl, triglycerides (TG) &gt;200 mg/dl, non-high density lipoprotein (non-HDL-C) &gt;160 mg/dl, or low HDL-C (&lt;40 mg/dl for men and &lt;50 mg/dl for women). Differences across Hispanic/Latino groups were tested using Mantel- Haenszel Chi-square and analysis of variance for categorical and continuous variables, respectively. Demographics, anthropometric measurements, lifestyle factors, dietary and metabolic profiles in those with abnormal vs. normal lipid components were compared using multivariable logistic regression models. Results: Mean age was 40.7 years (SE 0.23) and 48.3% are male. The overall prevalence of any dyslipidemia was 65.1%; prevalence of elevated LDL-C was 35.5%, and highest among Cubans (44.5%; p&lt;0.001). Low HDL-C was present in 41.9% overall, Central Americans had the highest prevalence (44.1%) but not significantly different from other groups (p=0.09). High TGs were seen in 14.9% overall, most commonly among Cubans (17.5%; p&lt;0.001). Elevated non-HDL-C was seen in 34.3% of the sample, and highest among Cubans (43.2%). Dominicans had the lowest prevalence of all four types of dyslipidemia. Multivariate analyses, across all Hispanics, show that prevalence of any dyslipidemia was significantly associated with increasing body mass index and diabetes diagnosis. Higher age was associated with a significantly lower prevalence of low HDL but a higher prevalence of all other dyslipidemia types. Female sex was associated with higher prevalence of low HDL-C but a lower prevalence of elevated TGs, non-HDL-C or LDL-C. Low physical activity was significantly associated with elevated TGs and low HDL-C. Alcohol use was associated with a lower prevalence of low HDL-C only. Conclusion: Dyslipidemia is very common among Hispanics/Latinos; Cubans seem particularly at risk. Low HDL-C and elevated LDL-C are most commonly seen. Across all Hispanics, determinants of dyslipidemia varied depending on the type of dyslipidemia. To prevent dyslipidemias, effective public health measures among the Hispanic/Latino population are needed.
Der Hohlfuss. Seine Entstehung und Behandlung.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency management of unexpected defects of hemostatic function in surgical patients
Authors: W. B. Wilson
Journal: JAMA (1967)

From time to time the surgeon is faced with the problem of an apparent defect of hemostatic function in a patient during surgery or postoperatively. This usually requires prompt and rational management, if undesirable complications are to be avoided. <h3>Preoperative Screening.—</h3> Although this paper deals primarily with operative and postoperative management of unexpected defective hemostasis, it is appropriate to mention first the preoperative screening of patients for bleeding tendency, since this is by far the most important approach to the problem. It should go without saying that surgery should never be undertaken lightly in patients with a known or suspected true defect of coagulation, no matter how mild the defect is supposed to be. Elective operation on the so-called mild hemophiliac, without proper preparation, can especially give cause for regret, since the postoperative management of these patients is always complicated and costly. A brief but appropriate history is the easiest
Non-invasive criteria for diagnosis of alcoholic hepatitis: use in clinical practice and correlation with prognosis
Authors: Emma Avitabile, Elisa Pose, Isabel Graupera, Marta Carol, Martina Perez, Marta Cervera, Núria Fabrellas, Adria Juanola, Octavi Bassegoda, Cristina Solé, Elsa Solà, Pere Ginès
Journal: Journal of Hepatology (2020)
Limitations and withdrawals of medical intervention in pediatric critical care
Authors: M. Levetown
Journal: JAMA (1994)

<h3>Objective.</h3> —To investigate the use and implementation in pediatric intensive care units (PICUs) of three levels of restriction of medical intervention: do not resuscitate (DNR), additional limitations of medical interventions beyond DNR, and withdrawal of care. <h3>Design.</h3> —Consecutive patients admitted between December 1989 and January 1992. <h3>Setting.</h3> —A total of 16 PICUs randomly selected to represent variability in size, teaching status, and presence or absence of a pediatric intensivist and unit coordination. <h3>Main Outcome Measures.</h3> —Profiles of children undergoing restrictions of medical interventions including the influence of chronic disease, the justifications for restrictions, and description of implementation practices. <h3>Patients.</h3> —All pediatric admissions undergoing restrictions (n=119) drawn from 5415 consecutive PICU admissions. <h3>Results.</h3> —A total of 94 (79%) of the restriction patients died during the PICU course, representing 38% of all deaths. A total of 73 restrictions (61%) resulted from acute disease, most involving the central nervous system or respiratory system. Restrictions were evenly divided between DNR (39%), additional limitations of medical intervention beyond DNR (27%), and withdrawals of medical intervention (34%). Survival decreased with increasing levels of restriction from 35% of DNR patients to 9% of patients with additional limitations and 2% of withdrawal patients. Imminent death was cited as the justification for restrictions in 70% of cases, no relational potential was cited in 22%, and excessive burden was cited in 8%. <h3>Conclusions.</h3> —Restrictions of medical intervention were used in all PICUs surveyed. Although severe chronic disease was common among restriction patients, acute disease was the predominant event precipitating placement of restrictions. Imminent death, not quality of life or excessive burden, was the most common justification. (<i>JAMA</i>. 1994;272:1271-1275)
Scientific program
Authors: Ostrom Md, Ziering Md, San Diego, Tolerability Getirizine, Alexander Small, P Thomson, D Drouin, Yang Wh, Mazza Ja, Moote Dw, Niagara Fulls, Lorber Rr, Danzig Mr, Ludwig Dds, Harrison Je, Loratadine Antihistamine, H Nonsedating, Antihistamines Hey, Lackey Rf, Hailden Dmsci, Hed Md, Van Hage-Hamsten, Jalowayski Flunisolide, Orgel Aa, Ostrom Nk, Welch Mj, San Diego, Clark Phd, Phillips Phd, Joseph Phd, Arsovski Md, Dokic Phd, Gavrilovski Phd, Stefanovski Phd, L Gligorovski, Dimitrovski Wd, Macedonia Phd, Beclomethasone Flunisolide, Rhlnltis Db'ropionate, Bronsky Ea, Mitchell Dq, Sun Diego, Peiikan Md, Boorsma Phd, The Nerherlunds, Fluticasone Propionate, Pearlman Ds, Rogenes Phd, Scott Ba, Hampel Howland, Martin Do, J Van Bavel, Scott Md, Rhlnltls Ba, J Selner, Webb Md, Milwee Pharmd, Mochizuki Maeda, Shigeta Morikawa, Goldberg Bj, L Ghekiere, Metzger Le Md, Kalunta Ci, Ascp Lad'pm, Los Angeles, Guha Md, Krishnaswamy Md Fccp, Reed Psgt, Johnson City, Nonspecific Bronchial, J Pouillard, Gard Md, Courtelle Dph, Likforman Dph, Pihouee Dph, Levy Dph, Bacot Bk, Hanson Cg, Abramson Sl, Rosenblatt Hm, V Lpn, Dolovich Peng, Despot Je, Eagleton Le Md, Otitis Media, Diaz Rr, G Bustos, D Bustos, Russel Dw, Atwater Js, Eilicott Cify, Winkelstein Md, Tiv Ataxia, Immotile Cllla, Tio Rc, Chiaramonte Lt, Schwartz Brooklyn, V Carregal, V Do, Rodriguez Rj, Stony Brook, Ramesh Md, Josephson As, Grant En, Rothenberg Me, Iowa City, Paul Me, Watson Tj, Kostyu Phd, Hanson Ic, Markert Ml, Mcanelly Ii, G Md, Hanson Icg, Spiegel Wa, M Md, Eckert Garbin, Ballcn Jl, Seggcv Js, Las Vegas, Jacobson Rs, Hoffman Dr, Nair Mpn, E Phd, Argentina Tampa, Fletcher-Vincent Sa, Reece Er, Malveaux Fj, Rourke O', Y Katz, Baena -Cagnani, Cora Oba, Katz Rm, Creticos Ps, Bernstein Di, J Md, Norman Ps, Noureddine Md, Thompson Ma, F Brennan, A Kagey-Sobotka, Lichtenstein Phd, Naclerio Rm, Allergen Challenge, Schwartz Lb, Kumar Sa, Spaulding Hs, Sutherland Rs, Aurora Co, Zuhair Ballas, Robert Rich, A Lussier, A Bs, Segal Db, J Phd, Craig Sj, Rogers Bl, Garman Rd, T Cell, Clones Spiegelberg, Beck Bs, Ishioka Gy
Journal: Journal of Allergy and Clinical Immunology (1994)
Transactions of the Vermont State Medical Society, 1900.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebrovascular complications of streptokinase infusion
Authors: M. S. Aldrich
Journal: JAMA (1985)

Ninety-one patients treated with streptokinase for vascular occlusion were studied retrospectively to document the incidence of cerebral hemorrhage. Three cerebrovascular complications occurred. Two patients had cerebral hemorrhage, one following limb ischemia, the other after acute myocardial infarction. The third patient received streptokinase for an occluded right subclavian bypass graft and suffered a right frontoparietal infarction, presumably secondary to retrograde embolization, but not angiographically proved. This incidence of cerebrovascular complications must be taken within the framework of the baseline incidence following systemic isehemia, but suggests that caution be exercised with this therapy. (<i>JAMA</i>1985;253:1777-1779)
Medical News
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EMERGENCY MEDICAL SERVICE FOR CIVILIAN DEFENSE
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Educating Doctors
Authors: D. Acheson
Journal: BMJ (1969)

Pregnant women, especially primigravidas, are highly susceptible to malaria infection, resulting in maternal anemia and low birth weight infants. Because circulating parasitemia is rare in the newborn, the cause of poor fetal outcomes has been unclear. We measured cytokine concentrations in placentas collected from women delivering in urban hospitals in malaria-holoendemic or nonendemic areas of Kenya. Normal placentas displayed a bias toward type 2 cytokines; type 1 cytokines IFN-γ and IL-2 were absent in placentas not exposed to malaria but present in a large proportion of placentas from a holoendemic area. TNF-α and TGF-β concentrations were significantly higher, and IL-10 concentrations significantly lower, in placentas from the holoendemic area. Among primigravidas, placental TNF-α concentrations were significantly higher in the presence of severe maternal anemia, and both IFN-γ and TNF-α were significantly elevated when a low birth weight, rather than normal weight, infant was delivered. We conclude that maternal malaria decreases IL-10 concentrations and elicits IFN-γ, IL-2, and TNF-α in the placenta, shifting the balance toward type 1 cytokines. This is the first demonstration that these placental cytokine changes are associated with poor pregnancy outcomes in humans.
Abstract 2437: Microfluidic device integrated with lipid nanoprobe for extracellular vesicle isolation toward non-invasive cancer diagnosis
Authors: Siyang Zheng, Yuan Wan, Mackenzie Maurer, Yi-Qiu Xia, Si-Jie Hao, Wen-Long Zhang, Nelson S. Yee
Journal: Cancer Research (2019)

Abstract Extracellular vesicles (EVs) can mediate intercellular communication by transferring cargo proteins and nucleic acids between cells. Recently, they have been demonstrated for potential value in cancer diagnostics and treatment monitoring. However, relevant clinical translation is mainly limited by technical challenges in EV isolation. We previously reported lipid nanoprobes, which is a nanomaterial system of labeling probe and capture probe. The labeling probe is constructed with a lipid molecule as the active component to label EVs rapidly and spontaneously with high efficiency, while the capture probe can isolate labeled EVs magnetically. Herein, we report on the development of a microfluidic device with integrated lipid nanoprobe for on-chip EV isolation towards instrument development for clinical translation. The nanostructured substrate of the device is integrated with a micromixer for one-step isolation of EVs from 1-ml plasma. We validated the device with plasma collected from pancreatic cancer patients, followed by DNA mutation detection of EV cargo. Size-tunable nanostructures are fabricated by patterning high-resolution iron thin films on fused silica substrates. By judicious thermal annealing, homogeneously dispersed iron nanoparticles are formed by fission and fusion on the substrate, which are served as a mask for silica dry-etching. Subsequently, selected lipid nanoprobes, which can instantaneously insert into lipid bilayers of EVs, are grafted onto the nanostructured substrate in a micromixer. This platform is verified first to isolate cultured cancer cell-derived EVs spiked-in plasma samples that emulated clinical samples. This platform is further applied to isolate EVs from pancreatic cancer patients’ plasma and identified KRASmutations in EV DNA with highly sensitive droplet digital PCR. Together, this platform enables rapid and efficient isolation of EVs from plasma specimens, and thus, holds great potential in clinical translation. Citation Format: Siyang Zheng, Yuan Wan, Mackenzie Maurer, Yi-Qiu Xia, Si-Jie Hao, Wen-Long Zhang, Nelson S. Yee. Microfluidic device integrated with lipid nanoprobe for extracellular vesicle isolation toward non-invasive cancer diagnosis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2437.
Update to Open Access Status
Authors: Stephanie Doupnik, Cadence Bowden, Steven Marcus
Journal: JAMA Psychiatry (2020)

D. Chamith Halahakoon, MBChB; Karel Kieslich, MUDr, MSc; Ciarán O’Driscoll, BTS, Gdip(Psych), DClinPsy; Akshay Nair, BMBCh, MA(Hons); Glyn Lewis, BA, MBBS, MSc, PhD; Jonathan P. Roiser, MA, PhD
Oral contraception by the sequential approach
Authors: E. T. Tyler
Journal: JAMA (1966)

To investigate the sequential approach to oral contraception, 509 fertile subjects were given 0.08 mg of mestranol daily for 14 days beginning on the fifth cycle day, followed by 0.08 mg of mestranol with 2 mg of norethindrone for six days. One pregnancy due to method failure occurred in 6,212 cycles of therapy. Thirty-seven patients reported amenorrhea in 57 cycles. Spotting or breakthrough bleeding or both occurred in 254 cycles. The majority of 88 incidences of gastrointestinal disturbance were evident in the first three cycles of therapy. Other side effects included weight changes, headache, leg pain, backache, and edema. Therapy was discontinued in 101 cases—in 24 of these for drug-related reasons. It was concluded that mestranol-norethindrone sequential medication provides an additional effective method of oral contraception.
The origin of the full-time faculty system. Implications for clinical research
Authors: W. B. Fye
Journal: JAMA (1991)

Clinical research has long been viewed as a fragile pursuit requiring special nurturing. The full-time clinical faculty system was introduced in the early 20th century to provide a milieu that would foster clinical investigation. This article, based on extensive archival research, will show that the main goal of the architects of the full-time system was to stimulate research by removing the incentive for medical professors to devote their main energy to practice. The plan was developed by preclinical scientists at The Johns Hopkins Medical School (Baltimore, Md) and was inaugurated there in 1913 with the financial assistance of the Rockefeller General Education Board. As other medical schools adopted traditional academic criteria for appointment and advancement, there were additional incentives for faculty members to undertake research. In the 1920s, the General Education Board yielded to pressure to liberalize its definition of full time and began to support medical schools that implemented what came to be known as the "geographic full-time plan." Increased government support and other factors encouraged the expansion of full-time plans and led to an impressive increase in the output of research. Today, growing pressure on full-time clinical faculty members to generate income from practice for themselves and their institutions threatens the future of clinical research in this country. (<i>JAMA</i>. 1991;265:1555-1562)