tbuckley/cabot-search huggingface dataset:
Carcinogenicity of Different Polycyclic Hydrocarbons in the Respiratory Tract of Hamsters<xref ref-type="fn" rid="fn2"><sup>2</sup></xref>
Authors: Arthur Sellakumar, Philippe Shubik
Journal: JNCI Journal of the National Cancer Institute (1974)

Isolation of naturally occurring sarcomagenic viruses of the mouse has been rare. After transplantation and cell-free passage of a spontaneous chloroleukemia originating in a BALB/cCr mouse, a virus was isolated with the physical and antigenic characteristics of the type-C RNA viruses of the mouse. This virus produced hemangiomatous and hemangiosarcomatous lesions which readily metastasized, could be passaged cell-free continuously in vivo, and produced murine sarcoma virus-like transformation on mouse and rat embryo cells in culture. The virus was typical of the predominant BALB/c type-C isolate from tumors in that it was BALB/c tropic and of the AKR serotype.
Stat Bite: School Performance in Brain Cancer Patients
Journal: JNCI Journal of the National Cancer Institute (2007)

In a Finnish study of childhood brain tumor patients, researchers examined patients' ninth grade report cards to determine the effect of cancer treatment on school performance.In Finland, students are scored from 4 (failed) to 10 (best).Overall, the cancer patients scored lower than healthy students, though the difference was more pronounced in girls.The greatest difference between patients and healthy students was in foreign language.The patients' age at diagnosis and whether they received cranial radiation treatment were associated with school performance in brain tumor patients.
Failure To Thrive in Older Adults
Authors: William W. Stead
Journal: Annals of Internal Medicine (1997)

Letters15 April 1997Failure To Thrive in Older AdultsWilliam W. Stead, MDWilliam W. Stead, MDArkansas Department of Health, Little Rock, AR 72205Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-8-199704150-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the article by Sarkisian and Lachs [1], the authors do not mention one of the most often overlooked and most readily corrected causes of failure to thrive in older adults: tuberculosis. Because we older people lived through a period of great prevalence of tuberculous infection, many of us retain viable organisms until death. In Arkansas, the incidence of active tuberculosis in persons older than 65 years of age is 10 times greater than the incidence in younger persons. A fact that is not commonly known is the twofold increase in the prevalence of positive tuberculin skin ...References1. Sarkisian CA, Lachs MS. “Failure to thrive” in older adults. Ann Intern Med. 1996; 124:1072-8. Google Scholar2. Case records of the Massachusetts General Hospital (Case 12-1963). N Engl J Med. 1963; 258:378-85. Google Scholar3. Stead WW, Lofgren JP, Warren E, Thomas C. Tuberculosis as an endemic and nosocomial infection among the elderly in nursing homes. N Engl J Med. 1985; 312:1483-7. Google Scholar4. Stead WW, To T. The significance of the tuberculin skin test in elderly persons. Ann Intern Med. 1987; 107:837-42. Google Scholar Author, Article, and Disclosure InformationAffiliations: Arkansas Department of Health, Little Rock, AR 72205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1997Volume 126, Issue 8Page: 668KeywordsAutopsyElderlyLesionsMycobacterium tuberculosisNursing homesPleural effusionSkin testsTuberculinTuberculosis Issue Published: 15 April 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
An Invertebrate Model of the Developmental Neurotoxicity of Insecticides: Effects of Chlorpyrifos and Dieldrin in Sea Urchin Embryos and Larvae
Authors: Gennady A. Buznikov, Lyudmila A. Nikitina, Vladimir V. Bezuglov, Jean M. Lauder, Stephanie Padilla, Theodore A. Slotkin
Journal: Environmental Health Perspectives (2001)

Chlorpyrifos targets mammalian brain development through a combination of effects directed at cholinergic receptors and intracellular signaling cascades that are involved in cell differentiation. We used sea urchin embryos as an invertebrate model system to explore the cellular mechanisms underlying the actions of chlorpyrifos and to delineate the critical period of developmental vulnerability. Sea urchin embryos and larvae were exposed to chlorpyrifos at different stages of development ranging from early cell cleavages through the prism stage. Although early cleavages were unaffected even at high chlorpyrifos concentrations, micromolar concentrations added at the mid-blastula stage evoked a prominent change in cell phenotype and overall larval structure, with appearance of pigmented cells followed by their accumulation in an extralarval cap that was extruded from the animal pole. At higher concentrations (20-40 microM), these abnormal cells constituted over 90% of the total cell number. Studies with cholinergic receptor blocking agents and protein kinase C inhibitors indicated two distinct types of effects, one mediated through stimulation of nicotinic cholinergic receptors and the other targeting intracellular signaling. The effects of chlorpyrifos were not mimicked by chlorpyrifos oxon, the active metabolite that inhibits cholinesterase, nor by nonorganophosphate cholinesterase inhibitors. Dieldrin, an organochlorine that targets GABA(A )receptors, was similarly ineffective. The effects of chlorpyrifos and its underlying cholinergic and signaling-related mechanisms parallel prior findings in mammalian embryonic central nervous system. Invertebrate test systems may thus provide both a screening procedure for potential neuroteratogenesis by organophosphate-related compounds, as well as a system with which to uncover novel mechanisms underlying developmental vulnerability.
Anatomy of the prostatic urethra
Authors: J. E. McNeal
Journal: JAMA (1984)

<h3>To the Editor.—</h3> The MEDICAL NEWS report of the talk by McGuire at the American Urologic Association Convention<sup>1</sup>contained some statements that require clarification. The report indicated that a new smooth-muscle sphincter has been identified extending along the entire length of the prostatic urethra and that it is critical for the physiological control of continence. In fact, this sphincter was first described 11 years ago in an autopsy study of the anatomy of the prostatic urethra.<sup>2</sup>In contrast to McGuire's findings, microscopic study showed that this sphincter is not homogeneous in composition. It is divided into two segments of equal length, and only the proximal segment is composed of smooth muscle. This segment was designated the<i>preprostatic sphincter</i>because its distal border, at the level of the base of the verumontanum, lies proximal to the orifices of all the major prostatic ducts. The distal half of the sphincter
Annals of Roentgenology. A Series of Monographic Atlases. Edited by James T. Case, M.D., President of the American Roentgen-Ray Society. Volume I. Mastoids Roentgenologically Considered.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CEREBROSPINAL MENINGITIS EPIDEMIC.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The World in Medicine
Authors: Rebecca Voelker
Journal: JAMA (1997)

<h3>First Time in Humans</h3> Twelve years after it was discovered in a Paris cooling tower,<i>Legionella parisiensis</i>has been isolated in a human patient for the first time. Researchers from Hôpital Paul Brousse in Villejuif, France, have reported that the organism was isolated from the tracheal aspirate of a 34-year-old woman who had undergone a liver transplant. The woman developed severe, nosocomially acquired pneumonia about a month after the surgery. She experienced neurologic deterioration and eventually became comatose. But she recovered after several weeks of antibiotic therapy and a second liver transplant. <i>Legionellaceae</i>bacteria include 42 species, 18 of which have been isolated from patients with pneumonia. The most celebrated member of the family is<i>Legionella pneumophila</i>, which causes Legionnaire disease and accounts for about 90% of<i>Legionella</i>infections. The French researchers reported their case in last month's<i>Journal of Clinical Microbiology</i>. <h3>Image of Cancer</h3> A new technique using magnetic
CARE OF HYPODERMIC NEEDLES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Texas State Medical Association, Twenty-eighth Annual Session, held at Fort Worth, Texas, 1896.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Journal of Diseass of Children, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrastructural Immunohistochemical Localization of Clara Cell Secretory Protein in Pulmonary Epithelium of Rabbits
Authors: Suzanne E. Patton, Ram P. Gupta, Susan Nishio, E. Mitchell Eddy, Anton M. Jetten, Charles G. Plopper, Paul Nettesheim, Gary E. R. Hook
Journal: Environmental Health Perspectives (1991)

Highly purified Clara cells (93 +/- 3%) isolated from the lungs of rabbits were used to produce an antiserum against Clara cell secretory proteins. This antiserum was used to identify and study the biosynthesis and secretion of [35S]methionine-labeled proteins from isolated Clara cells. The antiserum recognized one major secretory protein with apparent molecular weight of 6 kDa and reacted weakly with a higher molecular weight protein of about 180 kDa. Biosynthesis and secretion of these proteins was not detected in preparations of isolated alveolar type II cells or alveolar macrophages. Immunocytochemical localization of the antigen with colloidal gold indicated a dual localization in bronchiolar Clara cells. Gold labeling was found over the osmiophilic secretory granules of Clara cells and smooth endoplasmic reticulum. In tracheal Clara cells, labeling was found mostly in association with secretory granules and relatively little in association with the smooth endoplasmic reticulum. Labeling was also found over the lamellar bodies of type II cells, although the reaction was weak. Labeling of ciliated cells, alveolar type I cells, capillary endothelial cells, and alveolar macrophages was not distinguishable from background. These data indicate that Clara cells of both the bronchioles and trachea of rabbits synthesize and secrete the low molecular weight protein previously called Clara cell secretory protein (CCSP). This antigen does not belong to that group of surfactant proteins whose molecular weights range from 26 to 40 kDa.
Doing Everything
Authors: Nancy S. Knudsen
Journal: Annals of Internal Medicine (1999)

Letters19 January 1999Doing EverythingNancy S. Knudsen, MDNancy S. Knudsen, MDSt. Mary's Hospital; Amsterdam, NY 12010Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-2-199901190-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hurrah to Dr. Pisetsky! As a physician involved with hospice and palliative medicine, I commend him for his realization about what constitutes the care that physicians can provide (1). He succinctly and eloquently writes about what is the true meaning of “doing everything.” I disagree, however, with his statement “I can do nothing at all.” We actually can do a great deal. As Meier and colleagues have written (2), at that juncture in a patient's care, it is our responsibility and our duty to ensure that we address not only patients' physical symptoms (and manage these efficiently ...References1. Pisetsky DS. Doing everything. Ann Intern Med. 1998;128:869-70. LinkGoogle Scholar2. Meier D, Morrison S, Cassel C. Improving palliative care. Ann Intern Med. 1997;127:225-30. LinkGoogle Scholar3. Marwick C. Geriatricians want better end of life care. JAMA. 1997;277:445-6. CrossrefMedlineGoogle Scholar4. Feinberg A. The care of dying patients. Ann Intern Med. 1997;126:164-5. LinkGoogle Scholar5. Byock I. Dying Well. New York: Riverhead Books; 1997:32. Google Scholar Author, Article, and Disclosure InformationAuthors: Nancy S. Knudsen, MDAffiliations: St. Mary's Hospital; Amsterdam, NY 12010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDoing Everything David S. Pisetsky Doing Everything David S. Pisetsky Metrics 19 January 1999Volume 130, Issue 2Page: 165KeywordsEmotionsLaboratory testsPatients ePublished: 15 August 2000 Issue Published: 19 January 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
14th International Cancer Congress of the U.I.C.C., August 21-27, 1986-Budapest, Hungary
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article 14th International Cancer Congress of the U.I.C.C., August 21-27, 1986-Budapest, Hungary Get access JNCI: Journal of the National Cancer Institute, Volume 74, Issue 3, March 1985, Page 734, https://doi.org/10.1093/jnci/74.3.734-b Published: 01 March 1985
Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunction
Authors: Kevin N. Hogeveen, Patrice Cousin, Michel Pugeat, Didier Dewailly, Benoît Soudan, Geoffrey L. Hammond
Journal: Journal of Clinical Investigation (2002)

The access of testosterone and estradiol to target tissues is regulated by sex hormone–binding globulin (SHBG) in human blood. Serum SHBG levels are low in patients with hyperandrogenism, especially in association with polycystic ovarian syndrome (PCOS) and in individuals at risk for diabetes and heart disease. Here, we identify SHBG coding region variations from a compound heterozygous patient who presented with severe hyperandrogenism during pregnancy. Serum SHBG levels in this patient measured 2 years after her pregnancy were exceptionally low, and her non–protein-bound testosterone concentrations greatly exceeded the normal reference range. A single-nucleotide polymorphism within the proband's maternally derived SHBG allele encodes a missense mutation, P156L, which allows for normal steroid ligand binding but causes abnormal glycosylation and inefficient secretion of SHBG. This polymorphism was identified in four other patients with either PCOS, ioiopathic hirsutism, or ovarian failure. The proband's paternal SHBG allele carries a single-nucleotide deletion within exon 8, producing a reading-frame shift within the codon for E326 and a premature termination codon. CHO cells transfected with a SHBG cDNA carrying this mutation fail to secrete the predicted truncated form of SHBG. To our knowledge, these are the first examples of human SHBG variants linked to hyperandrogenism and ovarian dysfunction.
<i>QuickStats:</i>Percentage* of Adults Who Met Federal Guidelines for Aerobic Physical Activity,<sup>†</sup>by Poverty Status<sup>§</sup>— National Health Interview Survey, United States, 2014<sup>¶</sup>
Authors: U Per
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In 2014, the percentage of adults aged ≥18 years who met federal guidelines for aerobic physical activity increased as family income increased. The percentage of adults aged ≥18 years who met federal guidelines for aerobic physical activity ranged from 34.8% for those with family incomes <100% of the poverty level to 66.8% for those with family incomes ≥600% of the poverty level.
Incorrect Statement.
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal