tbuckley/cabot-search huggingface dataset:
Transposition of Values in Table
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heavy-particle therapy in acromegaly and Cushing disease
Authors: J. H. Lawrence
Journal: JAMA (1976)

A total of 349 patients with pituitary tumors, including acromegaly, Cushing disease, Nelson syndrome, prolactin-secreting adenoma, and chromophobe adenoma, have been treated with heavy-particle radiation during the past 17 years. The incidence of side effects has been low. Only 30 patients (8.6%) have died, most of preexisting cardiovascular complications. Heavy-particle therapy provides a form of treatment with no mortality and extremely low morbidity, and its use in treating pituitary disorders has resulted in dramatic improvement in the signs and symptoms of patients with acromegaly and Cushing disease. (<i>JAMA</i>235:2307-2310, 1976)
Creutzfeldt-Jakob disease in pituitary growth hormone recipients in the United States
Authors: J. E. Fradkin
Journal: JAMA (1991)

To assess the magnitude of Creutzfeldt-Jakob disease (CJD) occurrence among recipients of pituitary-derived human growth hormone (HGH), we conducted an epidemiologic follow-up of 6284 recipients of HGH distributed through the National Hormone and Pituitary Program. Seven neuropathologically confirmed cases of CJD have occurred in this population to date: six patients with clinical CJD presented with ataxia and imbalance, rather than with altered mentation, which is the most common initial manifestation in sporadic CJD, and one patient died in the preclinical incubation state of the disease. All seven cases occurred among the nearly 700 HGH recipients who started therapy before 1970. Since only 10% of the cohort has been followed up for the 15-year average incubation interval from midpoint of HGH treatment to onset of symptoms, the great majority of potentially exposed patients have not yet attained the requisite incubation period for expression of CJD. The median duration of HGH therapy of 100 months in the CJD cases was significantly longer than 41 months for all patients starting treatment before 1970; thus, the duration of pituitary HGH therapy is a major risk factor for CJD. (<i>JAMA</i>. 1991;265:880-884)
FDA Defended
Authors: Michael A. Wainstock
Journal: JAMA (1976)

<h3>To the Editor.—</h3> To the response of J. Richard Crout, MD, of the Bureau of Drugs (234:480, 1975) to the comment of Dr Freis (229:689, 1974) that "the Food and Drug Administration (FDA) is depriving American physicians and patients of useful hypertensive drugs," may I add the following. For the past three years, I have been a member of the panel of ophthalmic device classification of the FDA. This has necessitated many trips during the year to Washington, a close liason with the FDA and with other members of other panels dealing with drugs, and other devices. I can only say that I was most pleased with the total cooperation shown by government officials in all aspects of evaluating drugs and devices, bending backwards to give the manufacturer and public a break in interpretation of rules, but all within the framework of the law as it is spelled out. One
Clinical Questions
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
13. Children and Adolescents: <i>Standards of Medical Care in Diabetes—2021</i>
Journal: Diabetes Care (2020)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc21-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc21-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Correction
Journal: Thorax (2014)

The results section of this abstract should read:Results A total of 369 patients were referred over the 6 year period.Of these, 194 (52.6%) were admitted.The largest outcome group was total liberation from all forms of MV (45%).The remainder were shown to (1) require nocturnal non-invasive ventilation (NIV) (21%); (2) require nocturnal and intermittent daytime NIV (1%); (3) require long-term tracheostomy ventilation (19%); and (4) died in hospital (15%).Post-surgical and COPD patients had the highest rate of total liberation from mechanical ventilation at 60% and 54%, respectively.The median time from admission to tracheostomy decannulation was 18 days (9-33).NMD-CWD patients had the lowest hospital mortality (7%), whereas COPD patients had the highest hospital mortality (29%).The overall survival at 12 and 24 months was 55% and 47%, respectively.25% of the COPD patients were alive and 59% of the NMD-CWD patients were alive at 24 months (Figure 1).
Introduction
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA-RPS Adopts Resolutions on Medical Education and Resident Issues
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Posterior fossa hemorrhage. Localization by computerized tomography
Authors: B. D. Pressman
Journal: JAMA (1975)

The differentiation between pontine and cerebellar hemorrhage is important both prognostically and therapeutically but is often very difficult. Computerized axial tomography of the brain is a new, rapid, noninvasive method of studying intracranial disease. This technique proved useful in making this important differential diagnosis in the case reported here. (<i>JAMA</i>232:932-933, 1975)
Dengue Fever at the US-Mexico Border, 1995-1996
Journal: JAMA (1996)

Dengue is a mosquito-transmitted acute disease caused by any of four virus serotypes (DEN-1, DEN-2, DEN-3 and DEN-4) and is characterized by acute manifestations that can include fever, headache, myalgia, arthralgia, rash, nausea, and vomiting. On August 25, 1995, public health authorities in Mexico notified the Texas Department of Health (TDH) of an ongoing outbreak of dengue fever in the state of Tamaulipas, which borders south Texas. Because of the year-round presence of the Aedes aegypti mosquito (a major vector for dengue) in southernmost Texas and the frequent movement of persons across the U.S.-Mexico border, the outbreak in adjacent Tamaulipas suggested an increased potential for imported and autochthonous cases in Texas, as had occurred during 1980 and 1986. In response to the notification from Mexico, TDH intensified surveillance efforts for dengue, resulting in identification of 29 laboratory-diagnosed cases in Texas residents, including seven persons with no history of travel outside the state. This report summarizes results of dengue surveillance in the U.S.-Mexico border area during 1995-1996.
Comparative ultrastructural study of rat livers preserved in euro-collins or university of wisconsin solution
Authors: S Fratté
Journal: Hepatology (1991)

University of Wisconsin solution greatly lengthens the time liver storage is possible compared with all previous solutions used. To test whether this improvement is related to better preservation of the endothelial cell, which is thought to be the most vulnerable cell type in cold storage, we compared time-related ultrastructural changes in rat livers stored in this solution or in Euro-Collins solution. Rat livers were harvested after combined arterial and portal perfusion with the cold-storage solution. They were then preserved for different lengths of time in the same solution at 4° C before being perfusion-fixed and processed for light and electron microscopy. The first preservation damage was noted in endothelial cells; the time course of the lesions was similar in both solutions. After 2 hr of storage, enlarged and ruptured fenestrae with many gaps were observed. Swollen at 4 hr, the endothelial cells became stringlike at 10 hr, leading to stripped sinusoidal walls. Hepatocytes appeared better preserved in University of Wisconsin solution. The amount of glycogen, maintained near the control level at 24 hr in the latter, decreased dramatically between 0 and 4 hr in Euro-Collins solution, as ultrastructurally observed and biochemically confirmed. Furthermore, sinusoidal obstruction by blebs originating from the hepatocytes and quantified by image analysis on electron micrographs was markedly delayed. It was significantly less pronounced in University of Wisconsin solution at 24 hr than in Euro-Collins solution at 2 hr (p ≤ 0.05). Our findings confirm that endothelial cells are highly susceptible to preservation damage and show that University of Wisconsin solution does not improve preservation during storage. It is therefore suggested that protection is in part due to a lesser degree of microcirculatory disturbance by blebs stemming from hepatocytes. In addition, endothelial cell structure after preservation does not seem to be a reliable parameter for predicting graft outcome. (HEPATOLOGY 1991;13:1173–1180.)
The Findings of the Agency for Toxic Substances and Disease Registry Medical Waste Tracking Act Report
Authors: Maureen Y. Lichtveld, Sven E. Rodenbeck, Jeffrey A. Lybarger
Journal: Environmental Health Perspectives (1992)

The Agency for Toxic Substances and Disease Registry (ATSDR) report "The Public Health Implications of Medical Waste: A Report to Congress" has been finalized and submitted to Congress. The report is a comprehensive review of all available data and information on the subject. Based on the data developed in the report, ATSDR concludes that the general public is not likely to be adversely affected by medical waste generated in the traditional health setting. However, the increase of in-home health care and other sources of nonregulated medical waste (e.g., intravenous drug users) provides opportunities for the general public to contact medical waste. In addition, ATSDR concludes that public health concerns exist for selected occupations involved with medical waste. These populations include janitorial and laundry workers, nurses, emergency medical personnel, and refuse workers. The ATSDR report also defines what material should be managed as medical waste and identifies research needs related to medical waste.
THE FOURTH OF JULY—A WARNING
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Standard Classified Nomenclature of Disease.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Remote electrocardiography. Clinical experience with telephone transmission of electrocardiograms
Authors: S. Scheidt
Journal: JAMA (1974)

Two hundred three electrocardiograms were sent by 27 patients without assistance over standard telephone lines by means of a small device capable of multiple electrocardiographic lead transmission and automatic switching. Five patients with infrequently occurring symptoms were shown not to have paroxysmal arrhythmia. One with atypical chest pain had S-T segment elevation in a single electrocardiographic lead with pain, thus confirming the diagnosis of "variant angina." Drug dosage and other therapy of non-life-threatening arrhythmia were facilitated in eight patients. There were neither clinical nor electrocardiographic events of note in 11 patients who had been hospitalized with acute myocardial infarction and ventricular arrhythmia, in whom frequent remote ECGs were obtained during the month following hospital discharge. The value of remote electrocardiography during convalescence from acute myocardial infarction remains speculative. (<i>JAMA</i>230:1293-1294, 1974)
Abstract 5610: Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells
Authors: Wen-Bin Tsai
Journal: Cancer Research (2012)

Abstract Arginine (Arg) depletion with pegylated recombinant arginine deiminase (ADI-PEG20), a novel strategy under clinical investigations for treating Arg-auxotrophic malignancies in humans, has produced promising results in several types of cancer, including malignant melanoma. These tumors are sensitive to ADI-PEG20 because they do not express argininosuccinate synthetase (AS), the rate-limiting enzyme for the de novo biosynthesis of Arg, and therefore require Arg from extracellular source for survival. ADI-PEG20 treatment, which catalyzes the conversion of Arg into citrulline and ammonia, results in Arg deprivation. Melanoma cells develop ADI-resistance because of induced AS upregulation. We previously demonstrated that induction of AS expression by ADI-PEG20 involves upregulation of transcription regulator c-Myc that positively regulates AS expression, but the underlying mechanism of c-Myc induction is not known. Here, we show that ADI-PEG20 activates Ras signaling and its downstream ERK and PI3K/Akt/GSK-3β kinase cascades. These cascades phosphorylate c-Myc, resulting in c-Myc stabilization by attenuating the ubiquitin-mediated protein degradation mechanism. Furthermore, we demonstrated that intervention of these signaling pathway using PI3K/Akt inhibitors suppressed c-Myc induction and enhance ADI-mediated cell killing. Because the Ras activation signaling is known to play important roles in tumor growth, our findings have important implications in Arg-deprivation and cancer cell metabolism and suggest that targeting the Ras signaling pathway may be beneficial in ADI-PEG20 anti-cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5610. doi:1538-7445.AM2012-5610
Association of Ehlers-Danlos Syndrome With Dermatomyositis
Authors: Glenn G. Reynolds
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Since the original descriptions by Ehlers<sup>1</sup>amd Danlos<sup>2</sup>of familial joint laxity and cutis laxa, more than 200 cases have been reported, elucidating its hereditary nature and documenting its occurrence as an autosomal dominant, or sexlinked recessive condition.<sup>3</sup>Isolated case studies have demonstrated the concurrence of this condition with other disease entities, particularly bone and connective tissue abnormalities. In our patient with Ehlers-Danlos syndrome, another collagen disease developed, dermatomyositis, presenting the pictures of both pathologic problems. <h3>Report of a Case.—</h3> A 24-year-old white man complained of shoulder girdle weakness and swelling in October 1969. One month earlier he had noted difficulty breathing and a "sore" inside his mouth that was slow to heal. Excessive fatigue and soreness of the proximal muscles of his upper extremities accompanied swelling of the right arm and shoulder, and later the left. Subsequently he had difficulty with swallowing and