tbuckley/cabot-search huggingface dataset:
Changes in Mortality Rates from Leukemia in the First Five Years of Life
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annales de l'Institut Pasteur, Paris
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Atopic Dermatitis
Authors: Jonathan I. Silverberg
Journal: JAMA Dermatology (2014)

Atopic DermatitisAtopic dermatitis is an itchy rash that comes and goes with redness, scaling, and swelling.Atopic dermatitis can affect patients' sleep, daily living, and overall well-being.Damage to the skin barrier in atopic dermatitis allows for increased loss of water resulting in dry, itchy skin, skin infections, and increased skin allergies.Patients with atopic dermatitis may also have allergic diseases such as asthma, hay fever, and food allergies.
In vitro fragmentation of gallstones: Comparison of electrohydraulic, electromagnetic and piezoelectric shockwave lithotripters
Authors: H Schneider
Journal: Hepatology (1991)

To compare the fragmentation efficiency of three different shockwave systems, 63 human gallstone triplets were disintegrated in vitro using an electrohydraulic (MPL 9000, Dornier), an electromagnetic (Lithostar Plus, Siemens) and a piezoelectric (Piezolith 2300, R. Wolf) lithotripter. Since each stone triplet was obtained from the same gallbladder, the concrements of one such set were identical in physicochemical parameters. According to the maximal diameter, the calculi were divided into group A (6 to 15 mm) and group B (16 to 30 mm). Shockwave application was terminated when residual fragments measured 4 mm or less. Forty-five triplets were fragmented at energy settings mainly used in clinical treatment of patients with gallbladder stones (MPL 9000: 20 kV; Lithostar Plus: setting 9 (maximal); Piezolith 2300: setting 3). The fragmentation endpoint was achieved in group A (n = 3 x 36) with the Piezolith 2300 after median 150 (range = 50 to 500) pulses and with the Lithostar Plus after 150 (50 to 750) pulses compared with 500 (50 to 1,500) pulses using the MPL 9000 (p less than 0.01). In group B (n = 3 x 9) the Lithostar Plus (median = 750, range = 250 to 1,250 pluses) required fewer discharges than the Piezolith 2300 (1,250, 250 to 2,500 pulses; p less than 0.05) and the MPL (1,500, 500 to 1,600 [upper limit] pulses; p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Risky Driving Behaviors Among Teenagers-Gwinnett County, Georgia, 1993
Journal: JAMA (1994)

In the United States in 1991, approximately 6000 persons aged 16-20 years died from motor-vehicle crashes (MVCs)--twice as many as from any other cause of death among persons in this age group. During 1991, approximately 3000 crashes in Gwinnett County, Georgia (1990 population: 352,910) (26% of all crashes in Gwinnett County), involved at least one teenage driver (Gwinnett County Department of Transportation, unpublished data, 1992). Risky driving behaviors are among the risk factors for teenage MVC death and injury. To better characterize these risk factors, the Georgia Department of Human Resources, the Gwinnett County Board of Health, the community-based Gwinnett County Teen Traffic Tragedies Task Force, and CDC conducted a case-control study of MVCs among teenage drivers in Gwinnett County during 1993. This report summarizes the results of that study.
The People's Guide:
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methotrexate and azathioprine for severe atopic dermatitis: a 5-year follow-up study of a randomized controlled trial
Authors: L.A.A. Gerbens, S.A.S. Hamann, M.W.D. Brouwer, E. Roekevisch, M.M.G. Leeflang, P.I. Spuls
Journal: British Journal of Dermatology (2018)

Atopic dermatitis (AD), commonly known as eczema, is a chronic inflammatory skin disease causing intense itching and/or pain, which can affect the sleep and health‐related quality of life of both the patient and their family. It affects around 10–20% of people in developed countries. Worldwide AD is in the top 50 of most common diseases. Systemic treatment, meaning a medicine that works within the body rather than just being applied to the skin, is used for patients suffering from moderate‐to‐severe AD, and for whom topical (applied to the skin) treatment is insufficient. Long‐term evidence of most systemic treatments is lacking, especially of off‐label (that is not registered for AD) prescribed methotrexate (MTX) and azathioprine (AZA). This study, from the Netherlands, aimed to find out if MTX and AZA are effective and safe treatments in the long‐term. Patients participated in a follow‐up study of a randomized controlled trial (a study which compares different treatments in actual patients) in which they were seen every 3 months for 5 years. MTX and AZA doses could be in‐ or decreased if the patients’ doctors felt it necessary. The measure how effective the treatments were, the researchers used scoring systems that allowed them to compare symptoms after 5 years compared with when the patients started treatment – in this case, the SCORing Atopic Dermatitis (SCORAD) index in which a reduction in the score shows an improvement in symptoms, and Investigator Global Assessment (IGA). Adverse events (unwanted side effects) were also investigated. Drug survival (that is how long a patient is on treatment) was also analysed. Thirty‐five of 43 originally included patients participated in this follow up study, of which 27 completed the whole 5 years follow up. At year 5, mean relative reduction in SCORAD index was similar in MTX and AZA group: 52.8% and 53.8%. Twelve serious adverse events occurred in 5 years; for three the treatment was the possible cause. Drug survival was longer for MTX, but low in both groups after 5 years (MTX n = 5, AZA n = 1). Based on this relatively small study, MTX and AZA seem to be effective and safe as maintenance treatments in moderate‐to‐severe AD up to 5 years. Few patients in both groups stayed on their originally allocated drug, although some stopped taking the treatment because their symptoms had cleared. This low drug survival underlines the need for effective treatments for AD patients. Further, more long‐term and good sampled studies are needed.
Effect of ingestion of meat on plasma cholesterol of vegetarians
Authors: F. M. Sacks
Journal: JAMA (1981)

In a controlled trial, 21 strict vegetarians were studied prospectively for eight weeks: a two-week control period of the usual vegetarian diet was followed by four weeks, during which 250 g of beef was added isocalorically to the daily vegetarian diet and then by two weeks of the control diet. Plasma high-density lipoprotein-cholesterol did not change during the study, whereas plasma total cholesterol rose significantly by 19% at the end of the meat-eating period. Systolic blood pressure (BP) increased significantly during the meat eating by 3% over control values, whereas diastolic BP showed no major changes. Plasma renin activity, prostaglandin A and E levels, and urinary kallikrein, norepinephrine, and epinephrine excretions were within normal limits and did not change notably throughout the trial. The study suggests an adverse effect of consumption of beef on plasma lipid and BP levels. (<i>JAMA</i>1981;246:640-644)
Healing the Wounds
Authors: Carl E. Bartecchi
Journal: Annals of Internal Medicine (2019)

Letters20 August 2019Healing the WoundsCarl E. Bartecchi, MDCarl E. Bartecchi, MDUniversity of Colorado School of Medicine, Pueblo, Colorado (C.E.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0212 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:It is easy to dismiss the accomplishments of the Viet Cong and the North Vietnamese physicians; as I noted in my essay, few wrote about their medical experiences during their wars. I provided the credit for the photograph in the figure legend. I was so impressed with this image that I also included it in my book (1). That the event pictured may have happened did not surprise me, because I knew the capabilities of the Viet Cong surgeons, nurses, and aids and the environmental conditions in the U Minh Forest.According to The New York Times (2), ...References1. Bartecchi C. A Doctor's Vietnam Journal. Bennington, VT: Merriam Pr; 2012. Google Scholar2. Pringle J. Meanwhile: Closing the Circle on Vietnam. The New York Times. 13 March 2004. Accessed at www.nytimes.com/2004/03/13/opinion/meanwhile-closing-the-circle-on-vietnam.html on 15 January 2019. Google Scholar3. Page T. Another Vietnam. Washington, DC: National Geographic Pr; 2002. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Colorado School of Medicine, Pueblo, Colorado (C.E.B.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHealing the Wounds Carl E. Bartecchi Healing the Wounds Joel D. Brown Metrics 20 August 2019Volume 171, Issue 4Page: 306KeywordsConflicts of interestDisclosureFloodingHumidityRiversSurgeonsTemperature ePublished: 20 August 2019 Issue Published: 20 August 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Sun Glass as a Cautery.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes Mellitus
Authors: Samuel B. Beaser
Journal: New England Journal of Medicine (1950)

IN THIS progress report on diabetes mellitus, covering the years 1948 and 1949, the following subjects are considered: insulin chemistry; biochemistry and physiology; hyperglycemic factor; experimental diabetes and endocrine interrelations; diagnosis; psychiatric aspects of therapy; insulin therapy; insulin allergy; miscellaneous complications; intercapillary glomerulosclerosis; retinitis; surgery; pregnancy; and diabetic acidosis.Insulin ChemistryThe chemical nature of insulin has been analyzed by various technics.1 , 2 It appears to be a protein of a molecular weight (m.w.) of 48,000 at pH 7.0 and dissociates into four equal portions in acid solution. The latter can be further split by the enzymatic action of chymotrypsin into . . .
Abdominal Aorta Block May Aid Heart Patients
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contempo '90
Authors: Jeanette M. Smith
Journal: JAMA (1990)

In 1537, a young French field surgeon named Ambroise Paré, unaccustomed to battle scenes, was shocked to see the throats of three wounded soldiers "gently and benevolently" cut by a comrade, who explained that he wished the same for himself if seriously wounded. When another doomed soldier, rescued by Paré, recuperated under his care, the soldiers were so touched by his kindness that they collected a purse for the doctor. In Paré's time, much misery resulted from the belief that gunshot wounds should be cauterized, usually by a boiling oil mixture or scalding irons. Being inexperienced, Paré applied these remedies as instructed; however, when the oil supply ran out, he apprehensively experimented with a simple paste of egg yolk, oil of roses, and turpentine applied to the wounds. Those who were treated with the dressing rested in comfort, while the soldiers who received cautery for their wounds experienced fever, swelling,
Herpes Zoster
Authors: Max H. Weinberg
Journal: JAMA (1961)

<h3>To the Editor:—</h3> There is a statement in the article by Drs. Yaffee and Greenberg inThe Journal(<b>175:</b>1009 [March 18] 1961) which is not quite correct. The authors state: "The site of the original 3 lesions was in the lower abdomen in the distribution of L-4 and L-5 dermatomes." Dermatomes are in the lower part of the thigh, foreleg, and foot.
How good is the Rajka and Langeland score for assessing eczema?
Journal: British Journal of Dermatology (2021)

Atopic dermatitis (AD) is a common type of eczema seen in people of all ages, particularly children. It makes the skin inflamed, itchy and sore and affects many aspects of everyday life. There is a lot of research into different treatments, but it is hard to compare them because researchers use different ways to measure how severe the eczema is.
Lettsomian Lectures on the Ophthalmoscope and its Application
Authors: H. Walton
Journal: BMJ (1860)

one point of the method of treatment accidentally adopted-on the one side only some few that were left to be dressed, on the other the multitude of wounded, less this small number; but the small number, in virtue of the uniformity of result satis- fying the mind of this acute and truly logical observer, and leading him to the safe conclusion which his subsequent ex- perience amply confirmed.This, I repeat, is an unconscious illustration of the value of that numerical method which I have endeavoured to set before you, to explain, and to vindicate, in these three lectures.
Correction
Journal: BMJ (1954)

artery and the paired posterior spinal arteries each in two branches, one anterior and one posterior to the line of attachment of the posterior nerve roots to the spinal medulla.At each segmental level these descending branches of the vertebral artery are reinforced by lateral spinal arteries, branches of the appropriate segmental vessel, which enter the spinal canal through each intervertebral foramen and send branches to the spinal medulla along the anterior and posterior nerve roots.
Effect of food on the pharmacokinetics of dronabinol oral solution versus dronabinol capsules in healthy volunteers.
Authors: D. Alexander Oh, Neha Parikh, Varun Khurana, Christina Cognata Smith, Santosh Vetticaden
Journal: Journal of Clinical Oncology (2016)

e21593 Background: Dronabinol capsule containing a pharmaceutical tetrahydrocannabinol (THC) is approved for anorexia associated with weight loss in patients with AIDS and for cancer chemotherapy-induced nausea/vomiting in patients with inadequate response to conventional antiemetic therapy. The effects of food on absorption and bioavailability of dronabinol oral solution was compared with capsules. Methods: In an open-label, single-dose, 3-period crossover study, healthy volunteers were randomized to receive dronabinol oral solution 4.25 mg (fed) or dronabinol capsule 5 mg (fed or fasted). Dosing was separated by a 7-day washout period and administered under a fasted (overnight) or fed state (high-fat/calorie meal 30 minutes prior to dosing). Plasma pharmacokinetics was evaluated for dronabinol and the major metabolite, 11-OH-Δ9-THC. Results: Pharmacokinetic data were available for analysis in 54 volunteers. In the fed state, initial dronabinol absorption was rapid with oral solution vs capsules (mean Tlag , 0.15 vs 2.02 h, respectively). Further, in the fed state, 100% and 15% of volunteers receiving oral solution and capsules, respectively, had detectable plasma dronabinol levels 30 minutes post-dose. Inter-individual variability in plasma dronabinol concentrations during early absorption was less with oral solution vs capsules with %CV of 82.79%, 83.94%, and 90.68% and 318.54%, 250.33%, and 182.01% observed at 0.5, 1, and 2 h, respectively, following dosing. Food increased mean AUC0-t similarly for dronabinol oral solution and capsules vs capsules with fasting, increasing exposure to oral solution and capsules 2.1- to 2.4-fold. Mean time to maximum plasma concentration was similarly delayed for dronabinol oral solution (7.7 h) and capsules (5.6 h) with food vs capsules in the fasted state (1.7 h). Under fed conditions, AUC0-t and AUC0-inf were similar for the oral solution and capsules based on 11-OH-Δ9-THC levels. Conclusions: An appreciable food effect was observed for dronabinol oral solution and capsules. Dronabinol oral solution may offer therapeutic benefit to patients given its rapid absorption and lower inter-individual variability vs dronabinol capsules. Clinical trial information: NCT01448772.
NIMG-33. PROGNOSTIC VALUE OF CONTRAST ENHANCEMENT AND HISTOPATHOLOGICAL GRADING IN DIFFUSE GLIOMAS DEPENDS ON IDH1/2 MUTATION
Authors: Bogdana Suchorska, Annamaria Biczok, Markus Lenski, Nathalie Albert, Christine Schmid-Tannwald, Ulrich Schüller, Joerg-Christian Tonn
Journal: Neuro-Oncology (2016)

Contrast enhancement (CE) and anaplasia have been reported to indicate poor outcome in diffuse glioma. Recently, mutational status of the IDH1/2 gene and loss of heterozygosity on chromosome 1p/19q (LOH1p/19q) have gained additional relevance for the evaluation of clinical outcome. Currently, a three-way classification based on IDH1/2 mutation and LOH 1p/19q is used for classification, risk stratification and treatment planning. Here we aimed to re-evaluate CE and histopathological WHO grading as risk factors for survival within the framework of these molecular markers. 332 patients with diffuse glioma WHO grade II (n=189) or grade III (n=143) were stratified into 3 groups: IDH1/2 wild type (n=118), IDH1/2 mutated with (n=123) and without (n=91) LOH1p/19q. Preoperative magnetic resonance (MR) imaging was reviewed for presence of CE. Univariate and multivariate analyses were conducted taking into account CE, WHO grading, molecular signature, age, Karnofsky performance status, surgical procedure and adjuvant therapy. In multivariate analysis, CE was not associated with OS in IDH1/2 wild type tumors in contrast to gliomas with IDH1/2 mutation: Here, CE was independently associated with shorter survival (p=0.04). This effect was especially pronounced in tumors with IDH1/2 mutation without LOH 1p/19q. Histopathological grading according to WHO grades II or III discriminated patients with long versus short survival in IDH1/2 wild type gliomas only (OS p=0.001, multivariate analysis). In diffuse IDH1/2 wildtype gliomas of WHO grade II and III, CE is not associated with survival. In patients with an IDH1/2 mutation, presence of CE on initial MRI is linked to inferior survival, while grading is not. WHO grade II/III retains informative in IDH1/2 wildtype tumors only. Hence, the value of CE as a prognostic marker has to be redefined with respect to the molecular signature of the tumor.