tbuckley/cabot-search huggingface dataset:
Avoidance of Side-Reactions and Loss of Drug Efficacy During Long-Term Administration of Carbonic Anhydrase Inhibitors by Concomitant Supplemental Electrolyte Administration
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress in Hematology
Authors: Ward D. Noyes
Journal: JAMA (1974)

A clear and succinct analysis of a rapidly developing field is a welcome relief from the deluge of primary data. In this eighth volume, Elmer Brown has brought together 12 reviews on subjects ranging from molecular hematology to direct clinical applications. Among many scholarly chapters, those of most interest to me included the one on antiglobulin reagents in hemolytic anemias, in which Hugh Chaplin, Jr., gently dissects the intricacies and pitfalls of the Coomb test, particularly helping one to understand those cases with a negative reaction in the face of clinical evidence for autoimmune hemolysis. Wendell Rosse follows with an article on measurements of immune hemolysis, pursuing other aspects of hemolytic disease due to antibodies and complement. In the chapter on regulation of myelopoiesis, Fred Stohlman, Jr., describes the substantial progress in bone marrow cultures and the subsequent understanding of those factors that modify the growth and distribution of granulocytes.
Myopic Hypotheses
Authors: Arthur Loewy
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Goldstein et al, in reporting their study in a LETTER, "Myopia and Dental Caries" (<b>218</b>:1572, 1971) could have carried the observations over a longer time period to further substantiate their contention of correlation by reversal—a sort of "cross over." I have observed that when dental caries has been eliminated by the ultimate achievement of the edentulous state after many years, the myopia that may have been present either reverses or even reverts to hyperopia, albeit presbyopia. Thus, when caries is gone, myopia is lessened. This is surely strong support for the cited correlation. Mine is an armchair study that includes reading chapter 10, "How to Talk Back to a Statistic," from an old book by Darrell Huff.<sup>1</sup>While a reader is initially encouraged by the presence of probability figures in the medical literature, the immediate question applied to any report is, "What else can your results
Locally advanced head and neck squamous cell carcinomas treated with TPF(docetaxel, cisplatin, 5-FU)induction chemotherapy
Authors: Jun Taguchi, Yasushi Shimizu, Ichiro Kinoshita, Rio Honma, Satoshi Takeuchi, Kazuhiko Tsuchiya, Hiroki Shirato, Akihiro Homma, Satoshi Fukuda, Hirotoshi Akita
Journal: Annals of Oncology (2015)
Issues in graduate medical education
Authors: J. S. Millis
Journal: JAMA (1966)

Happily, in discussion of the issues in graduate medical education, I was not asked to suggest the resolution of these issues nor the solution of these problems. Therefore, I shall simply delineate issues and identify problems and take the liberty of expressing my personal opinion about their relative importance. I shall confine the discussion to five issues which I believe to be of paramount importance, in my layman's view, and must be faced and resolved most promptly. These issues are (1) discontinuity in the educational process, (2) the persistence of the apprenticeship in the process of education and training, (3) the ineffectiveness and inadequacy in the organization in our present institutions of medical education, (4) the failure to clearly decide on the role of the university in graduate medical education, and (5) the present unsatisfactory balance between generalization and specialization. <h3>Discontinuity</h3> The process of educating and training the future physician
Practice of Urology and Syphilology.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tennis Leg
Authors: Avrum I. Froimson
Journal: JAMA (1969)

Tennis leg is a painful condition of partial tearing of the medial belly of the gastrocnemius, caused by overstretching the muscle by concomitant ankle dorsiflexion and full knee extension. Contributory factors are muscle fatigue and degenerative changes. Simple conservative treatment is effective and permanent disability does not result. Prodromic calf aching has been discussed and permits preventive measures to be taken. A diagnosis of plantaris tendon rupture is erroneous.
Acute Gouty Pericarditis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: T. HORN
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access Atlas of Skin Cancer Anthony du Vivier . London : Gower Med. Publ ., 1991 . 248 pp., illus. $95 THOMAS HORN THOMAS HORN Division of Dermatopathology, and Oral Pathology, The Johns Hopkins Medical Institutions600 N. Wolfe St. Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 9, 6 May 1992, Page 720, https://doi.org/10.1093/jnci/84.9.720 Published: 06 May 1992
Effects of Sodium d-Thyroxine on Normal and Hyperchloesteremic Men
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PD10: Light penetration into a six‐layer skin model for 200–1000 nm
Authors: S Butt, A Mcmullan, R Dawe, S Ibbotson
Journal: British Journal of Dermatology (2021)

Over the last few years, we have seen 11 patients presenting with proton pump inhibitor (PPI) photosensitivity at our tertiary referral photodiagnostic service and in our local dermatology department.Many adverse effects, including the discovery in 2020 of an almost twofold increased risk of severe COVID-19, of this widely used group of drugs have been noted (Lee SW, Ha EK, Yeniova A € O et al.Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching.Gut 2020; 70: 76-84.).Although PPI-induced phototoxicity has been described, phototest results have not been reported and all clinical presentations have not been described.We aimed to identify all patients with PPI photosensitivity who presented to our unit.We sought to better understand their clinical characteristics, blood test results and photodiagnostic results.We retrospectively reviewed all case notes and investigation results of patients who were diagnosed with PPI photosensitivity.Eleven patients were identified to have been seen between 2014 and 2019.Two patients were male and nine were female.Mean duration of disease was 3Á6 years and mean duration of PPI ingestion was 5 years.Five patients presented with a drug-induced lupus pattern [subcutaneous lupus erythematosus (SCLE; n = 2), papulosquamous SCLE and discoid (n = 1), tumid (n = 1) and acute cutaneous (n = 1)], four with drug-induced phototoxicity (sunburn-like) and two with a drug-induced solar urticaria relating to a lupus mechanism.The majority of patients reported symptoms on sun-exposed sites.The most common indication for PPI prescription was gastroesophageal reflux disease with omeprazole being the most commonly prescribed PPI.All patients underwent phototesting.Three patients were not on an PPI while undergoing phototesting and did not demonstrate photosensitivity.Of the remaining patients who underwent phototesting the most common finding was delayed sensitivity to ultraviolet A and to visible light.Drug-induced photosensitivity can be a challenging diagnostic entity owing to the varied clinical presentation and heterogeneous time to onset.We present this case series to further help clinicians in recognizing the clinical and diagnostic pattern of photosensitivity present with PPI use.
Oncozoons and the Search for Carcinogen-Indicator Fishes
Authors: Clyde J. Dawe
Journal: Environmental Health Perspectives (1987)

This essay attempts to bring into perspective the importance of hereditary as well as environmental factors as potential causes of neoplasms in feral fishes. Concepts delineated by Knudson regarding hereditary cancers in man and experimental animals will probably be found operative in certain demographic units (oncozoons) among feral fishes bearing neoplasms. Hereditary factors include: antioncogenes (regulatory genes), which act as suppressors of neoplastic expression in homozygous, heterozygous, or hemizygous states, as well as constitutional (structural) genes that influence carcinogen activation or deactivation through enzyme gene products, genes that influence immunologic responses, and gene abnormalities that favor spontaneous or induced mutations. The two major classes of genes (oncogenes and antioncogenes) that influence the manifestation of cancers appear to operate through different mechanisms, but conceivable interactions have not been widely investigated, especially in tumor enzootics among feral fishes. Some explorations have been undertaken in the laboratory by Anders and collaborators in studies of suppressor genes (antioncogenes) and the cellular sarc gene (an oncogene) in melanophoromas in platyfish-swordtail hybrids and backcrosses. Some feral fish oncozoons that exhibit features of hereditary oncodemes as seen in man have been tentatively identified here as candidate systems to be studied more intensively in laboratories, particularly using cytogenetic analysis and breeding methods. In the search for carcinogen-indicator fish species in feral habitats, the traditional approach has been to survey fish populations with the aim of first finding enzootics of fish neoplasia.(ABSTRACT TRUNCATED AT 250 WORDS)
Table of Contents
Authors: Patrick Pun, Christina Wyatt, Gregg Silverman, Doua Azzouz, Adam Mor, Tamara Isakova, Geoffrey Block, Malgorzata Kasztan, David Pollock, Khashayar Sakhaee, Bénédicte Stengel, Jeffrey Kopp, Clifford Kashtan, Jie Ding, Guido Garosi, Laurence Heidet, Laura Massella, Koichi Nakanishi, Kandai Nozu, Alessandra Renieri, Michelle Rheault, Fang Wang, Oliver Gross, Vandana Dua Niyyar, W Charles O'neill, Marc Vervloet, Adriana Van Ballegooijen, Atsumi Miyagawa, Sawako Tatsumi, Wako Takahama, Osamu Fujii, Kenta Nagamoto, Emi Kinoshita, Kengo Nomura, Kayo Ikuta, Toru Fujii, Ai Hanazaki, Ichiro Kaneko, Hiroko Segawa, Ken-Ichi Miyamoto, Sara Desideri, Karen Onions, Yan Qiu, Raina Ramnath, Matthew Butler, Christopher Neal, Matthew King, Andrew Salmon, Moin Saleem, Gavin Welsh, C Michel, Simon Satchell, Andrew Salmon, Rebecca Foster, Ruhul Amin, John Asplin, Daniel Jung, Mohamed Bashir, Altayeb Alshaikh, Sireesha Ratakonda, Sapna Sharma, Sohee Jeon, Ignacio Granja, Dietrich Matern, Hatim Hassan, Yoshiro Nakajima, Hiroshi Kiyonari, Yoshiko Mukumoto, Takahiko Yokoyama, Jae-Seung Moon, Chin Mun, Jung-Ho Kim, Jen-Young Cho, Sung-Dong Park, Tae-Yoon Park, Jin-Su Shin, Chun-Chang Ho, Yong-Beom Park, Sankar Ghosh, Alfred Bothwell, Sang-Won Lee, Sang-Kyou Lee, Luis Toro, Víctor Barrientos, Pablo León, Macarena Rojas, Magdalena Gonzalez, Alvaro González-Ibáñez, Sebastián Illanes, Keigo Sugikawa, Néstor Abarzúa, César Bascuñán, Katherine Arcos, Carlos Fuentealba, Ana Tong, Alvaro Elorza, Eugenia Pinto, Rodrigo Alzamora, Carlos Romero, Luis Michea, Yasmine Neirijnck, Antoine Reginensi, Kirsten Renkema, Filippo Massa, Vladimir Kozlov, Haroun Dhib, Ernie Bongers, Wout Feitz, Albertien Van Eerde, Veronique Lefebvre, V Knoers, Mansoureh Tabatabaei, Herbert Schulz, Helen Mcneill, Franz Schaefer, Michael Wegner, Elisabeth Sock, Andreas Schedl, Maxim Durand, Florian Dubois, Cécile Dejou, Eugénie Durand, Richard Danger, Mélanie Chesneau, Carole Brosseau, Pierrick Guerif, Jean-Paul Soulillou, Nicolas Degauque, Jean-François Eliaou, Magali Giral, Nathalie Bonnefoy, Sophie Brouard, Laura Labriola, Michel Jadoul, Martine Cohen-Solal, Pablo Ureña-Torres, Maria Fusaro, Jorge Cannata-Andía, Thomas Nickolas, Mario Plebani, Maria Mereu, Andrea Aghi, Maurizio Gallieni, The Reply, Pablo Antonio, David Goodkin, Brian Bieber, Cynthia Lim, Jason Choo, Meng Chan, Keng Thye, Anne-Laure Faucon, Michel Daudon, Vincent Frochot, Dominique Bazin, Benoît Terris, Valérie Caudwell, Ritambhra Nada, Raja Ramachandran, Ashwani Kumar, K Gupta, Ashish Sharma
Journal: Kidney International (2018)
Book Review International Studies on the Relation Between the Private and Official Practice of Medicine with Special Reference to the Prevention of Diseas . conducted for The Milbank Memorial Fund. By Sir Arthur Newsholme, K.C.B., M.D., F.R.C.P. Volume Two. Belgium, France, Italy, Jugoslavia, Hungary, Poland, Czecho-Slovakia. London: George Allen &amp; Unwin, Ltd. Baltimore: Williams &amp; Wilkins Co. Price $4.00.
Journal: New England Journal of Medicine (1931)
Journal club
Authors: Hannah Sainsbury
Journal: Thorax (2021)

Dexmedetomidine has been shown to have superior anti-inflammatory and immunomodulatory properties compared with propofol.However, clear clinical benefits remain unproven.Hughes and colleagues (NEJM 2021;384:1424) explore if dexmedetomidine may be superior to propofol in patients with critical illness due to sepsis requiring targeted sedation.This multicentre double-blinded, non-inferiority trial conducted over 13 sites in the USA enrolled 432 patients, who were randomised in a 1:1 ratio with a total of 422 receiving a trial drug.Overall, there was no difference in the primary endpoint of days alive without delirium or coma during the intervention period of 14 days (adjusted median 10.7 vs 10.8 days; OR 0.96; 95% CI 0.74 to 1.26).Moreover, there was no difference between the secondary endpoints of ventilator-free days at 28 days (adjusted median 23.7 vs 24.0 days; OR 0.98; 95% CI 0.63 to 1.51) and death at 90 days (38% vs 39%; HR 1.06; 95% CI 0.74 to 1.52).Key statistics from the trial demonstrate the complexity of achieving appropriate sedation with patients in both groups only spending 57%-60% of the time at target sedation and up to half of the patients in both groups having rescue doses of midazolam.To conclude, this trial reinforces current sedation guidance.
On Rounds, 7 a.m
Authors: Susan Rakley
Journal: Annals of Internal Medicine (2000)

Ad Libitum4 July 2000On Rounds, 7 a.mSusan Rakley, MDSusan Rakley, MDNorthbrook, IL 60062 (Rakley)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-1-200007040-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Congratulations to Susan Rakley, MD, of Northbook, Illinois, winner of the 1999 Annals Poetry Prize. Dr. Rakley's poem was published in the 19 October 1999 issues of Annals (vol. 131, no. 8) and is reprinted here.Yes, I have something in my eye,I havedeathin my eye.Curious that an ordinarily inert substancelike deathcan cause such a reactionwhen deposited in an unaccustomed placelike an eye. Author, Article, and Disclosure InformationAffiliations: Northbrook, IL 60062 (Rakley) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 July 2000Volume 133, Issue 1Page: 54 ePublished: 15 August 2000 Issue Published: 4 July 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Phase Ia, first-in-human study of AbGn-107, a novel antibody-drug conjugate (ADC), in patients with gastric, colorectal, pancreatic, or biliary cancers.
Authors: Andrew H. Ko, Andrew L. Coveler, Benjamin L. Schlechter, Tanios S. Bekaii-Saab, Brian M. Wolpin, Jeffrey William Clark, Yi-Lin Cheng, Ting-Ying Cheng, Peter J. Langecker, Shih-Yao Lin
Journal: Journal of Clinical Oncology (2020)

713 Background: AbGn-107 is an ADC directed against AG-7 antigen, a Lewis A-like glycol-epitope expressed in 24-61% of gastric (G), colorectal (CRC), pancreatic (PDA), and biliary (BIL) cancers. Based on promising antitumor activity of AbGn-107 in both in vitro and in vivo preclinical studies, we performed a Phase Ia trial in pts with the aforementioned GI malignancies. Methods: Standard 3+3 dose escalation was used. Key eligibility criteria: locally adv or metastatic G, CRC, PDA, or BIL cancer, previously treated, ECOG PS 0-1; positive AG-7 expression was not required. Two dosing intervals were tested: AbGn-107 administered i.v. Q4 weeks (at doses ranging from 0.1-1.2 mg/kg) and Q2 weeks (at doses from 0.8-1.0 mg/kg). DLTs were based on grade 3/4 hematologic and non-heme AEs occurring during the initial 4-week rx window. Pts were treated until dz progression or unacceptable toxicity, with tumor assessments Q8 weeks. 1o objectives: safety and MTD; 2o objectives: PK, immunogenicity, and efficacy defined by ORR (RECIST 1.1). Results: 35 patients were enrolled across 6 dose levels (median age 61.5 yo (range 40 – 81); G (0)/CRC (12)/PDA (20)/BIL (3); median # lines of prior rx = 3 (range 1-7). Safety: 5 pts experienced Grade 3 or 4 neutropenia, all at higher dose levels, with 1 episode of febrile neutropenia. Other frequent drug-related AEs, mostly grade 1/2, inc. fatigue (29%), nausea (20%), and diarrhea (14%). DLTs include grade 4 CK elevation (n = 1) at 0.8 mg/kg Q4W and grade 3 arthralgias (n = 1) at 1.2 mg/kg Q4W. MTD was not reached at either 1.2 mg/kg Q4W or 0.8 mg/kg Q2W; the 1.0 mg/kg Q2W cohort will complete enrollment in Oct 2019. Efficacy: Median duration of treatment = 56 days (range, 8 – 225 days); best response observed to date is stable dz lasting &gt; 6 months at 0.8 mg/kg Q4W and Q2W cohorts (n = 1 each). Conclusions: Overall, AbGn-107 appears well-tolerated with encouraging prelim signs of efficacy (prolonged dz control) in non-biomarker selected pts with advanced GI cancers. Pre-screening for high AG-7 expression is underway for subjects with G, CRC, PDA, and BIL cancers for the cohort expansion phase of this study, which will be open across multiple sites in U.S. and Taiwan. Clinical trial information: NCT02908451.
Reply to Arnaldo Stanzione, Massimo Imbriaco, and Renato Cuocolo’s Letter to the Editor re: Marloes van der Leest, Bas Israël, Eric Bastiaan Cornel, et al. High Diagnostic Performance of Short Magnetic Resonance Imaging Protocols for Prostate Cancer Detection in Biopsy-naïve Men: The Next Step in Magnetic Resonance Imaging Accessibility. Eur Urol 2019;76:574–81. Are We Meeting Our Standards? Stringent Prostate Imaging Reporting and Data System Acquisition Requirements Might be Limiting Prostate…
Authors: Marloes van der Leest, Bas Israël, Rianne R.M. Engels, Jelle O. Barentsz
Journal: European Urology (2019)