Cocaine and Body Temperature Regulation
Authors: Craig G. Crandall
Journal: Annals of Internal Medicine (2002)

Letters19 November 2002Cocaine and Body Temperature RegulationCraig G. Crandall, PhD, Wanpen Vongpatanasin, MD, and Ronald G. Victor, MDCraig G. Crandall, PhDInstitute for Exercise and Environmental Medicine; Presbyterian Hospital of Dallas (Crandall)University of Texas Southwestern Medical Center at Dallas; Dallas, TX 75390-8586 (Vongpatanasin, Victor)Search for more papers by this author, Wanpen Vongpatanasin, MDInstitute for Exercise and Environmental Medicine; Presbyterian Hospital of Dallas (Crandall)University of Texas Southwestern Medical Center at Dallas; Dallas, TX 75390-8586 (Vongpatanasin, Victor)Search for more papers by this author, and Ronald G. Victor, MDInstitute for Exercise and Environmental Medicine; Presbyterian Hospital of Dallas (Crandall)University of Texas Southwestern Medical Center at Dallas; Dallas, TX 75390-8586 (Vongpatanasin, Victor)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-10-200211190-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree that responses associated with the dose of cocaine administered may be very different from those that occur with cocaine toxicity. However, others have shown that cocaine-induced elevations in core temperature are dose dependent (1, 2). Thus, it is reasonable to suggest that if greater doses of cocaine had been administered, cutaneous vasodilation, sweating, and heat perception may have been even more attenuated. Given that sedating agents decrease internal temperature even in resting healthy persons who do not use cocaine (3), it is not surprising that treatment with sedation agents attenuates the elevation in temperature and improves ...References1. Chung LL, Pechnick RN, Bova MP, George R. Acute and chronic administration of cocaine produces hyperthermia in the rat. Proc West Pharmacol Soc. 1991;34:27-8. [PMID: 1788296] MedlineGoogle Scholar2. Lomax P, Daniel KA. Cocaine and body temperature in the rat: effects of ambient temperature. Pharmacology. 1990;40:103-9. [PMID: 2345771] CrossrefMedlineGoogle Scholar3. Gilbert SS, van den Heuvel CJ, Dawson D. Daytime melatonin and temazepam in young adult humans: equivalent effects on sleep latency and body temperatures. J Physiol. 1999;514 3 905-14. [PMID: 9882760] CrossrefMedlineGoogle Scholar4. Johnson JM, Proppe DW. Cardiovascular adjustments to heat stress.. In: Blatteis C, Fregly M, eds. Handbook of Physiology: Adaptations to the Environment. Bethesda, MD: American Physiological Soc; 1996:215-43. Google Scholar5. Kellogg DL, Pérgola PE, Piest KL, Kosiba WA, Crandall CG, Grossmann M, et al. . Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission. Circ Res. 1995;77:1222-8. [PMID: 7586235] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Craig G. Crandall, PhD; Wanpen Vongpatanasin, MD; Ronald G. Victor, MDAffiliations: Institute for Exercise and Environmental Medicine; Presbyterian Hospital of Dallas (Crandall)University of Texas Southwestern Medical Center at Dallas; Dallas, TX 75390-8586 (Vongpatanasin, Victor) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMechanism of Cocaine-Induced Hyperthermia in Humans Craig G. Crandall , Wanpen Vongpatanasin , and Ronald G. Victor Cocaine and Body Temperature Regulation Joshua G. Schier , Robert S. Hoffman , and Lewis S. Nelson Metrics 19 November 2002Volume 137, Issue 10Page: 855-856KeywordsAtropineBlood flowCholinergicsCocainePerceptionSedationTemperatureToxicityVasodilationVasodilators ePublished: 19 November 2002 Issue Published: 19 November 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...