tbuckley/cabot-search huggingface dataset:
GERMS FROM MUMMIES.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Omission of "Ab-" and "Junctional."
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress continues against cystic fibrosis
Authors: Phil Gunby
Journal: JAMA (1984)

Two US Department of Transportation agencies are modifying their child restraint seating regulations to make it easier for persons traveling with small children to use the same safety seat in both their motor vehicles and on commercial airplane flights. At present, seats certified by the department's National Highway Traffic Safety Administration cannot be used on airliners without special certification from the Federal Aviation Administration, which also is part of the department. The new common standard is expected to go into effect next Feb 28. The department estimates that more than 600 small children die in traffic accidents in this country each year. It further estimates—from data submitted by state agencies—that two of three (67%) of the infants transported in motor vehicles now are placed in infant restraint seats, but that fewer than half (44%) of children between the ages of 1 and 4 years are placed in safety seats.
THE ACTION OF VITAMIN D
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Reviews
Authors: Jane E. Paulson, L.A. Demers-Desrosiers, Hellmuth Freyberger, Hans-Werner Künsebeck, Ira M. Lesser, Wolfgang Lempa, Walter Wellmann, Hans-Jürgen Avenarius, W.D. TenHouten, K.D. Hoppe, J.E. Bogen, D.O. Walter, Wolfgang Pommer, Peter Diederichs, Max Hummel, Peter Kratzer, Gerd Offermann, Martin Molzahn, Rolf Sandell
Journal: Psychotherapy and Psychosomatics (1985)
Mom1 is a semi-dominant modifier of intestinal adenoma siza and multiplicity in Min/+ mice Gould, K.A. et al. Genetics 144, 1769–1776 Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice Gould, K.A. et al. Genetics 144, 1777–1785
Journal: Trends in Genetics (1997)
Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols
Authors: Stefan S. Bielack, Beate Kempf-Bielack, Günter Delling, G. Ulrich Exner, Silke Flege, Knut Helmke, Rainer Kotz, Mechthild Salzer-Kuntschik, Matthias Werner, Winfried Winkelmann, Andreas Zoubek, Heribert Jürgens, Kurt Winkler
Journal: Journal of Clinical Oncology (2002)

To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localized extremity disease.
IL-32 and streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2
Authors: B. Heinhuis, M. I. Koenders, F. A. van de Loo, P. L. E. M. van Lent, S.-H. Kim, C. A. Dinarello, L. A. B. Joosten, W. B. van den Berg
Journal: Annals of the Rheumatic Diseases (2010)

Purpose Interleukin 32 (IL-32) might play an important role in the pathogenesis of RA by inducing cytokines and chemokines.IL-32 is highly expressed in RA synovial tissue and strongly correlates with synovial infl ammation, tumour necrosis factor (TNF)α and IL-1 expression.IL-32 alone is not that potent, but it appears to enhance sensitivity of synovial cells to proinfl ammatory stimuli.Here, we investigated potential synergistic effects of IL-32γ with Streptococcus pyogenes cell wall fragments, which contain predominantly TLR2/NOD2 ligands, in human fi broblast-like synoviocytes (FLS).In addition, we explored the synergistic arthritogenicity of IL-32γ and SCW fragments in wildtype and IL-1 deficient mice.Method FLS from 10 arthritis patients were isolated and transduced with an adenoviral vector encoding for IL-32γ (AdIL-32γ) followed by SCW stimulation.To investigate in vivo synergy, we injected AdIL-32γ virus together with SCW fragments intra-articularly into knee joints of wildtype and IL-1 defi cient mice. ResultsIn human FLS synergistic upregulation of the proinfl ammatory cytokines IL-1β, IL-6 and TNFα was found and similar observation was made for the chemokines CCL2, CCL20 and CXCL8.Of great importance, we also identifi ed synergistic upregulation of matrix degrading enzymes, including MMP1 and MMP3, linking the IL-32 synergy to erosive processes.Part of the synergy may be related to the marked increase of the pattern recognition receptors TLR2 and NOD2.In wildtype mice we observed a prolonged and severe arthritis injected with AdIL-32γ/SCW compared to AdControl/SCW.Furthermore, histological analysis showed apart from enhanced numbers of infl ammatory cells, severe cartilage proteoglycan depletion, and irreversible chondrocyte death in mice exposed to IL-32γ and TLR2/NOD2 ligands.Remarkably, IL-1 defi cient mice injected with AdIL-32γ/SCW were completely protected against the destructive arthritis observed in wildtype mice.Conclusions The observed synergistic effect between IL-32γ and TLR2/NOD2 ligands identifi es an important amplifying pathway in the development of destructive arthritis which on August 11,
Classification criteria for systemic lupus erythematosus. Frequency in normal patients
Authors: L. Wolf
Journal: JAMA (1976)

One hundred healthy women were examined prospectively during their annual physical examination for any of the preliminary criteria of systemic lupus erythematosus (SLE). No patient had more than three of the criteria; 50 (50%) had none. The preliminary criteria were effective in excluding normal patients. Three of 19 patients taking oral contraceptives had serum antinuclear antibody (ANA), whereas only one of 81 non-pill users had serum ANA (<i>P</i>&lt;.05). None of these patients with positive ANA had clinical evidence of SLE. (<i>JAMA</i>236:1497-1499, 1976)
Reducing Mortality of Myocardial Infarction Is 'Ultimate Criterion' of Anticoagulant Therapy
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12770: Left-Atrial Contractile Contribution to Left Ventricle Filling is Preserved in Moderate Chronic Heart Failure
Authors: Brendan N Putko, Ian Paterson, Richard B Thompson, Justin A Ezekowitz, Jason R Dyck, Todd Anderson, Gavin Y Oudit
Journal: Circulation (2014)

Introduction: The extent that left atrium (LA) functional remodeling is impacted by left ventricle (LV) systolic function or clinical history in patients with chronic heart failure (HF) is unresolved. Cardiac imaging and plasma biomarkers may provide valuable information in this regard. Hypothesis: Elastic and active contributions to LV stroke volume (LV SV) are variable, independent of LV systolic function and reflected in natriuretic peptide measurements. Methods: We recruited 27 controls without overt cardiovascular disease and 68 patients with moderate HF, including preserved and reduced LV ejection fraction (LVEF). Cardiac MRI was used to evaluate LV volumes at end diastole and end systole, and LA volumes at end diastole, diastasis and end systole to determine passive and active volume changes. Plasma mid-region pro-atrial and N-terminal pro-brain natriuretic peptides (MR-proANP and NT-proBNP, respectively) were measured. Results: Elastic LA contribution to LV SV was significantly lower in HF (median, IQR: 14%, 8-23%) than controls (24%, 17-30%; p=0.001), but active contribution was not (23%, 0-34% vs 24%, 21-31%; p=0.163). In patients with HF, active LA contribution to LV SV was negatively associated with history of hypertension (β=-0.41, p=0.007) and positively associated with aging (β=0.40, p=0.008) in a multiple linear regression model. Seven of nine subjects with HF and a history of atrial fibrillation (AF), but in sinus rhythm (SR) on the day of study, had active LA contributions to LV SV &gt;15%. Increased LA volume at end diastole (β=0.51, p=0.001) and LVEF (β=-0.33, p=0.008) were independently associated with NT-proBNP (β=0.51, p=0.001) in a model that included age and history of AF. Similarly, LA volume at end diastole (β=0.48, p=0.001) was independently associated with MR-proANP in a model that included age and history of AF. Notably, natriuretic propeptides were not associated with elastic or active LA contributions to LV SV. Conclusions: Heart failure is characterized by preserved LA active contribution to LV SV, regardless of LVEF, which increases with age, and is modifiable by hypertension and AF. Imaging-based assessment can elucidate the contribution of LA function in HF and may provide insight into the impact of AF in patients with HF.
Evaluation of a local anesthetic agent. Bupivacaine hydrochloride (Marcaine)
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alterations in Endogenous Nitric Oxide Production After Cardiopulmonary Bypass in Lambs With Normal and Increased Pulmonary Blood Flow
Authors: D. Michael McMullan, Janine M. Bekker, Andrew J. Parry, Michael J. Johengen, Alexander Kon, R. Scott Heidersbach, Stephen M. Black, Jeffrey R. Fineman
Journal: Circulation (2000)

Background —After cardiopulmonary bypass (CPB), altered vascular reactivity is a major source of complications, particularly for children with increased pulmonary blood flow. Although changes in agonist-induced NO activity are well described after CPB, potential changes in basal NO production and their role in post-CPB pulmonary hypertension remain unclear. By using aortopulmonary vascular graft placement in the fetal lamb (shunt lambs), we established a unique model of pulmonary hypertension that mimics congenital heart disease with increased pulmonary blood flow. The objective of the present study was to investigate potential alterations in endogenous NO production after CPB in lambs with normal and increased pulmonary blood flow. Methods and Results —Vascular pressures and blood flows were monitored in 1-month-old lambs (n=7) with increased pulmonary blood flow and 6 age-matched control lambs. After shunt closure, hypothermic CPB (25°C) was performed for 2 hours. The hemodynamic variables were monitored for 4 hours after CPB. Before, during, and after CPB, peripheral lung biopsies were performed to determine tissue NO, nitrite, nitrate, and cGMP concentrations; total NO synthase (NOS) activity; and endothelial NOS protein levels. Hypothermic CPB increased both mean pulmonary arterial pressure and left pulmonary vascular resistance ( P &lt;0.05). The increase in pulmonary arterial pressure induced in shunt lambs was greater than that induced in control lambs ( P &lt;0.05). Four hours after CPB, tissue concentrations of NO, nitrite, nitrate, and cGMP were decreased to ≈70% of pre-CPB levels in both control and shunt lambs ( P &lt;0.05). Total NOS activity and endothelial NOS protein levels were unchanged. Conclusions —Modest decreases in basal NO production, the inability to increase NO production, or both may play a role in the altered pulmonary vascular reactivity after CPB. The decrease in NO is independent of gene expression. However, other mechanisms for this decrease, such as substrate or cofactor availability, warrant further study.
The Pattern of Growth Hormone Delivery to Peripheral Tissues Determines Insulin-Like Growth Factor-1 and Lipolytic Responses in Obese Subjects
Authors: Sowmya Surya, Jeffrey F. Horowitz, Naila Goldenberg, Alla Sakharova, Matthew Harber, Andrea S. Cornford, Kathy Symons, Ariel L. Barkan
Journal: Endocrine Reviews (2009)

It is unclear whether the pattern of GH delivery to peripheral tissues has important effects. The aim of the study was to compare the effects of pulsatile vs. continuous administration of GH upon metabolic and IGF-I parameters in obese subjects. The study was conducted at the General Clinical Research Center at the University of Michigan Medical Center. Four men and five women with abdominal obesity (body mass index, 33 ± 3 kg/m2; body fat, 40 ± 3%) participated in the study. GH (0.5 mg/m2 · d) was given iv for 3 d as: 1) continuous infusion (C); and 2) pulsatile boluses (P) (15% of the dose at 0700, 1300, and 1800 h and 55% at 2400 h). These trials were preceded by a basal period (B) when subjects received normal saline. Rate of lipolysis and hepatic glucose production were evaluated using stable isotope tracer techniques. The composite index of insulin sensitivity (Matsuda index) was assessed using oral glucose tolerance test. The increase in plasma IGF-I concentrations was greater (P < 0.05) with continuous GH infusion (211 ± 31, 423 ± 38, and 309 ± 34 μg/liter for B, C, and P, respectively). Muscle IGF-I mRNA was significantly increased (P < 0.05) only after the continuous GH infusion (1.2 ± 0.4, 4.4 ± 1.3, and 2.3 ± 0.6 arbitrary units, for B, C, and P, respectively). Only pulsatile GH augmented the rate of lipolysis (4.1 ± 0.3, 4.8 ± 0.7, and 7.1 ± 1.1 μmol/kg · min for B, C, and P, respectively). GH had no effect on hepatic glucose production, but both modes of GH administration were equally effective in impairing insulin sensitivity. These findings indicate that, in obese subjects, discrete components of GH secretory pattern may differentially affect IGF-I generation and lipolytic responses.
AIDS:2008
Authors: AARON GLATT
Journal: Annals of Internal Medicine (1987)

Ad Libitum1 December 1987AIDS:2008AARON GLATT, M.D.AARON GLATT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-6-947_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"Sir, the doors are sealed. The decontamination quarantine systems are at full strength. All systems go."The President heaved a deep sigh of relief. What a trying time it had been for him personally and for the country these last few years. Preventing the spread of the virus had been the only topic on the World Council agenda in the last five years. Why didn't they realize back in the 80s the full extent of the problem? AIDS wasn't just going to go away peacefully and easily. And now, in 2008, the only hope rested in their current plan.Who... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: AARON GLATT, M.D.Affiliations: Brooklyn, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1987Volume 107, Issue 6Page: 947-947KeywordsAIDSDecontaminationQuarantines ePublished: 1 December 2008 Issue Published: 1 December 1987 PDF downloadLoading ...
GRADUATE MEDICAL STUDY.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical characteristics of early oral cancer
Authors: D. P. Shedd
Journal: JAMA (1971)

Recognition of a moderately advanced cancer in the oral mucosa is not difficult provided the examiner can visualize the area. Most doctors and dentists will react appropriately when they see a lesion over 2 cm in diameter of an ulcerative or fungating nature. However, such prompt recognition frequently does not take place in early oral cancers, in those which are less than 1 cm in diameter, or in those which are in a stage prior to fungation or ulceration. The purpose of this presentation is to describe the clinical characteristics of the early oral cancer and to define it in histopathologic terms. In recent years, some clinicians have had the opportunity to see a significant number of such lesions and to develop a concept of the beginning of neoplasia in oral mucosa. <h3>Clinical Recognition.—</h3> Many oral cancers are found against a background of a basically abnormal mucosa, which may be
Editors, Contents, Cover details
Authors: Lindsey Drayton, Susanne Brink, Paige Shaklee, Rolf Van Der Sanden, Ria Otten, Patrick Scheffmann, Ralph Adolphs, Renee Baillargeon, Nick Chater, Peter Dayan, Stanislas Dehaene, Daniel Dennett, Yadin Dudai, Andreas Engel, Martha Farah, Angela Friederici, Okihide Hikosaka, Ray Jackendoff, Philip Johnson-Laird, Nancy Kanwisher, Christof Koch, Marta Kutas, Nikos Logothetis, James Mcclelland, Earl Miller, Elizabeth Phelps, Russell Poldrack, Marcus Raichle, Trevor Robbins, Anthony Wagner, Vincent Walsh, Jennifer Misyak, Derrick Watson, Nathan Griffi, Alex Mouzakitis, Lucy Petro, Lars Muckli, Lisa Feldman Barrett, Zulqarnain Khan, Jennifer Dy, Dana Brooks, Andrew Young, A Burton, John Monahan, Peter Imrey, Valerie Reyna, David Faigman, Joshua Buckholtz, Marc Cyriel, M Pennartz, Evan Kidd, Seamus Donnelly, Morten Christiansen, David Badre, Derek Nee
Journal: Trends in Cognitive Sciences (2018)