tbuckley/cabot-search huggingface dataset:
NCCN NewsNCCN Publishes Patient Education Resources for Gliomas—Its First in a Series on Brain CancerFree NCCN Pocket Guidelines Available for Myeloproliferative NeoplasmsUpdated Patient Resources Now Available for Malignant Pleural Mesothelioma
Journal: Journal of the National Comprehensive Cancer Network (2017)

NCCN has published the NCCN Guidelines for Patients and NCCN Quick Guide sheets for Brain Cancer -Gliomas-the first in a series of patient education resources focused on Brain Cancer.Published by NCCN through support of the NCCN Foundation, and, in part through funding from NCCN Foundation's Team Pound the Pavement for Patients, these resources inform patients about their disease and the treatment options available to them."Access to new, easy-to-understand treatment information for patients with Brain Cancer empowers these patients to make informed decisions about their care.We are excited to present the new NCCN Guidelines for Patients -Gliomas and look forward to publication of the entire Brain Cancer Series," said Marcie R. Reeder, MPH, Executive Director, NCCN Foundation.Support from NCCN Foundation's Team Pound the Pavement for Patients was donated in honor of Melanie Moletzsky, an employee of NCCN who was diagnosed with anaplastic astrocytoma-a type of glioma-in 2015.During her time in treatment-nearly 2 years-Ms.Moletzsky learned a lot about living with brain cancer and the side effects of the disease and its treatment.She shares her insights in the new NCCN Guidelines for Patients: Brain Cancer -Gliomas.These resources are available free of charge on NCCN.org/patients, as well as on the free NCCN Patient Guides for Cancer mobile app, available for Android and iOS devices.NCCN plans to publish additional patient resources focusing on other forms of brain cancer in the future."NCCN Foundation is incredibly grateful to Melanie for sharing her survivorship story, as well as her insight for patients who are living with brain cancer.Her experience indeed will be inspiring for others and complements the invaluable guidance provided by NCCN's expert physicians," said Ms. Reeder.NCCN Guidelines for Patients, patient-friendly translations of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines), are easy-to-understand resources based on the same clinical practice guidelines used by healthcare professionals around the world to determine the best way to treat a patient with cancer.Each resource features unbiased expert guidance from the nation's leading cancer centers designed to help people living with cancer talk with their physicians about the best treatment options for their disease.NCCN Guidelines for Patients and NCCN Quick Guide sheets-one-page summaries of key points in the patient guidelines-are written in plain language and include patientfriendly elements, such as questions to ask your doctor, a glossary of terms, and medical illustrations of anatomy, tests, and treatment.NCCN Guidelines for Patients and NCCN Quick Guide sheets DO NOT replace the expertise and clinical judgment of the clinician.NCCN currently offers NCCN Guidelines for Patients for the following: Brain, Breast,
II cancro del retto
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urology in Women: A Handbook of Urinary Diseases in the Female Sex.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Trauma
Authors: Melvin H. Worth
Journal: JAMA (1976)

THE INCREASING frequency in urban areas of penetrating abdominal wounds and in suburban and rural areas of blunt abdominal injuries makes trauma one of the leading causes of the acute abdomen in current surgical practice. Trauma represents an accelerated form of general surgery, and the usual criteria of peritoneal irritation and visceral damage should constitute the indications for celiotomy. <h3>To Operate or Not?</h3> Until the end of World War II, suspicion of peritoneal penetration was considered an adequate indication for abdominal exploration. The high incidence of normal findings in these circumstances suggested that approximately one third of patients could avoid operation by selective evaluation of individual cases. Although selective celiotomy requires a larger staff for observation, greater clinical acumen than routine exploration, and modification for local circumstances, the principle is valid. Peritoneal penetration under more controlled circumstances (ie, paracentesis, peritoneal dialysis, closed liver biopsy) is considered routine and safe on
Changing patterns of methaqualone abuse. A survey of 246 fatalities
Authors: C. V. Wetli
Journal: JAMA (1983)

Of 246 methaqualone-related deaths identified during an 11-year period (1971 through 1981), 76% have occurred since 1977 and 72% have involved fatal trauma. One third of the victims died in vehicular crashes. Sharp increases in methaqualone-related traumatic suicides, nonvehicular accidents, and homicides have occurred since 1978. This report discusses demographic and toxicological findings, particularly in regard to counterfeit methaqualone. The pattern of fatal methaqualone abuse has changed from an overdose phenomenon in the early 1970s to one of traumatic death. Victims frequently have exhibited poor judgment, impulsive behavior, and somnolence while attempting to function in their environment. The socioeconomic impact of recreational methaqualone abuse should be curtailed by appropriate governmental action and restraint in the prescribing of methaqualone. (<i>JAMA</i>1983;249:621-626)
SCIENTIFIC CHARITY.
Authors: BAYARD HOLMES
Journal: JAMA (1896)

There are two distinct ideas pictured by the word charity, and the notions which these ideas convey have little intrinsically in common. In one sense charity stands for fellowship, fraternity, good will, love, human sympathy and justice. In this sense charity is good and will always be of unexceptional application. It is in this sense that Paul and Portia used it in those well-known and much-abused paragraphs. In its second sense, charity embraces all those ideas represented by alms, almsgiving and all those institutions, organizations and systems employed in giving gratuitous relief to the poor. It is in this latter sense alone that charity is used by me in this discussion. In this sense there can be but a limited application of the terms scientific charity. Scientific charity is really no charity at all, because science and reason direct all the energies of society not to the alleviation of the
Canad Anaesthetist's Society Journal, Toronto
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Breastcancer Profile<i>chip</i>: Utilization of microarray technology to predict prognosis and improve clinical management of breast cancer
Authors: N. Borie, D. Birnbaum, F. Bertucci, P. Viens, J. Jacquemier, T. Bachelot, S. Deraco, S. Debono, F. Hermitte, A. Koki
Journal: Journal of Clinical Oncology (2004)

9658 Background: Microarray technology has significantly contributed to enhance understanding of the diverse molecular mechanisms driving tumorigenesis. However, results from gene expression profiling (GEP) research have yet to be translated to the clinical setting. In this study, we describe the development of the Breast Cancer ProfileChip (BCPC), a device based on GEP for molecular characterization and management of breast cancer. Methods: 220 patients who received anthracyclin based adjuvant chemotherapy were selected from the Institut Paoli-Calmettes. All tissues were analyzed on nylon cDNA microarrays (DiscoveryChip) containing 9,000 genes by isotopic labeling based on RT of total RNA. Signatures for phenotypic markers (ER, PR, BCL2, EGFR, VEGFA, MIB1, ERBB2) and prognosis (metastasis, lymph node status) were calculated by t-test with moderate correction for multiple variable testing. The number of discriminatory genes required to optimize specificity and sensitivity for each defined gene signature were calculated by ProfileSoftware Corporate, and validated on an independent series of patients from Centre Léon Bérard (n=110). All gene signatures were subsequently cross-validated by correlative immunohistochemistry and/or fluorescence in-situ hybridization. Results: Identified signatures comprised of 30 to 150 genes were transferred to the BCPC, a biochip containing 1200 cDNA's. An amplification method based on linear PCR, colorimetric detection of hybridized complexes, and quantification on a flat bed scanner was developed to ensure clinical feasibility of the BCPC. Expression profiles are performed with 500ng total RNA with high reproducibility (mean CV =5%), and automatically quantified and analyzed with ProfileSoftware Cancer. All derived gene signatures are quantitative, sensitive, and highly reproducible (mean CV = 5%). Conclusions: The BCPC is the first analytical tool based on microarray technology engineered to fit the needs of a hospital-based platform; providing a viable method to assess a series of clinical parameters that may contribute to improved breast cancer management. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Ipsogen Ipsogen; Ipsogen SAS
CLINICAL PSYCHOLOGY
Authors: OSCAR A. PARSONS
Journal: American Journal of Psychiatry (1964)

Several major impressions emerged from this brief review: 1) the study of cognitive functions from new vantage points, derived from information theory and ego psychology, holds promise for the future; 2) studies of psychological deficit in brain damage are still, to a large degree, concerned with diagnosis but increasing emphasis is being given to the study of patterns of impairment associated with different brain dysfunctions; 3) studies in schizophrenia are currently focused upon explication of the social, interpersonal and affective determinants of cognitive deficit as a function of pre-morbid status.
Contents
Authors: Roger Steinert, Shveta Jindal Bali, Chris Hodge, Michael Lawless, Timothy Roberts, Gerard Sutton, Yi Zhang, Lan Zhang, Zhen Song, Dong Sun, Han Liu, Song Fu, Dong Liu, Ping Liu, Kevin Kirk, Liliana Werner, Ryan Jaber, Susan Strenk, Lawrence Strenk, Nick Mamalis, David Mcmahon, Darin Goldman, Adam Rogers
Journal: Ophthalmology (2012)
Dicroceliasis (lancet fluke disease) in an HIV seropositive man
Authors: J. J. Drabick
Journal: JAMA (1988)

Dicroceliasis is an unusual zoonotic trematode infection caused by the lancet liver fluke,<i>Dicrocoelium dendriticum</i>. Grazing herbivores (usually sheep or cattle) are the definitive hosts. The life cycle proceeds through two intermediate hosts: the land snail and the field ant. Human infection is acquired by consuming the field ant. This case report describes a human immunodeficiency virus— seropositive patient who presumably acquired this parasite from bottled water contaminated with ants. A brief discussion of the parasitology, pathology, clinical findings and treatment is presented. (<i>JAMA</i>1988;259:567-568)
Reply
Authors: Manoj Kumar, Shiv K. Sarin, Barjesh C. Sharma
Journal: Hepatology (2007)

We thank Fazili et al. for their interest in our article. The development of antibodies to hepatitis B e antigen (anti-HBe) and hepatitis B surface antigen (anti-HBs) were lower in the lamivudine-treated group relative to placebo, although these did not reach statistical significance. We concur with Fazili et al. that it is an important observation, and it seems plausible that interruption of the protective host immune response may be a consequence of pharmacologic therapy. Because virus-specific antibody-producing B cells are enriched early after acute viral infection,1 the host immune system needs to be exposed to viral antigen during the early phase in order to induce production of neutralizing antibodies. Therefore, giving lamivudine early may inhibit the production of neutralizing antibodies to some extent.2 A previous study also reported that after the use of lamivudine in treating acute viral hepatitis B, 18.18% of patients lost serum HBsAg but did not develop anti-HBs during treatment and follow-up.3 Nevertheless, it has also been reported that anti-HBs did not develop in 10% of untreated patients with acute hepatitis B.4 As rightly mentioned, only a long-term follow-up of such patients would help us know the risk of reactivation of hepatitis B virus (HBV) in patients treated with antiviral therapy. We do believe however that treatment of patients with severe acute hepatitis B with lamivudine is not harmful. Lamivudine or other more potent antivirals may be useful in a small subset of patients with acute hepatitis B who have more severe disease at presentation and high HBV DNA. Although there are no studies defining the patients with more severe disease, we suggest that such patients might include individuals with fulminant acute hepatitis B,5 or individuals who fulfill any 2 of the following criteria:3, 6 (1) hepatic encephalopathy; (2) serum bilirubin ≥ 10.0 mg/dL; and (3) international normalized ratio (INR) ≥ 1.6, especially if it is increasing. Because patients belonging to the above categories would often need liver transplantation, it would be best to achieve, through use of potent antiviral drugs, HBV DNA levels which are undetectable or as low as possible at the time of liver transplantation, as measured with current real-time polymerase chain reaction methods. Whether such a therapeutic approach may translate into spontaneous recovery in a proportion of patients awaiting transplantation can only be predicted by the use of antiviral drugs in proper RCTs including such a group of patients. Manoj Kumar M.D., D.M.*, Shiv K. Sarin M.D., D.M.*, Barjesh C. Sharma M.D., D.M.*, * Department of Gastroenterology, G. B. Pant Hospital, New Delhi, India.
The SUPPORT Project and Improving Care for Seriously III Patients
Authors: Margaret L. Campbell
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Although we agree with the conclusions of the SUPPORT project<sup>1</sup>that substantial shortcomings exist in care for seriously ill hospitalized patients, specifically regarding end-of-life decision making, and that the "phase II" interventions failed to improve care or patient outcomes, we are not surprised. We agree that greater individual and societal commitment as well as more practical and forceful measures are needed. We have a combined experience in an acute care hospital with a nurse-physician partnership for end-of-life care that we call the Comprehensive Supportive Care Team (CSCT).<sup>2</sup>Our experience with this subspecialty practice in affecting the way physicians care for dying patients is quite different from that reported by the SUPPORT investigators. Our data show reductions in ICU and hospital lengths of stay for dying patients with a corresponding reduction in hospital charges and use of resources through appropriate care planning with consideration of the
Carbohydrate and Protein Contents of Grain Dusts in Relation to Dust Morphology
Authors: William V. Dashek, Stephen A. Olenchock, John E. Mayfield, George H. Wirtz, Dean E. Wolz, Craig A. Young
Journal: Environmental Health Perspectives (1986)

Grain dusts contain a variety of materials which are potentially hazardous to the health of workers in the grain industry. Because the characterization of grain dusts is incomplete, we are defining the botanical, chemical, and microbial contents of several grain dusts collected from grain elevators in the Duluth-Superior regions of the U.S. Here, we report certain of the carbohydrate and protein contents of dusts in relation to dust morphology. Examination of the gross morphologies of the dusts revealed that, except for corn, each dust contained either husk or pericarp (seed coat in the case of flax) fragments in addition to respirable particles. When viewed with the light microscope, the fragments appeared as elongated, pointed structures. The possibility that certain of the fragments within corn, settled, and spring wheat were derived from cell walls was suggested by the detection of pentoses following colorimetric assay of neutralized 2 N trifluoroacetic acid hydrolyzates of these dusts. The presence of pentoses together with the occurrence of proteins within water washings of grain dusts suggests that glycoproteins may be present within the dusts. With scanning electron microscopy, each dust was found to consist of a distinct assortment of particles in addition to respirable particles. Small husk fragments and "trichome-like" objects were common to all but corn dust.
The Tyrosine Kinase Receptor RET Interacts in Vivo with Aryl Hydrocarbon Receptor-Interacting Protein to Alter Survivin Availability
Authors: Manuela Vargiolu, Daniela Fusco, Ivana Kurelac, Dietmar Dirnberger, Ralf Baumeister, Isabella Morra, Antonio Melcarne, Roberto Rimondini, Giovanni Romeo, Elena Bonora
Journal: Endocrine Reviews (2009)

Context: RET is a tyrosine kinase transmembrane receptor expressed in two main alternative isoforms: RET9 and RET51.RET transduces a positive signal leading to survival, differentiation, or migration in the presence of its ligand ®FN Nonstandard abbreviations (such as GDNF) must be used more than twice to be retained in abstract.Text is treated separately.ʲglialcell line-derived neurotrophic factor, whereas in its absence a proapoptotic fragment that initiates a negative signaling for apoptosis is generated.The signal transduction mechanisms leading to apoptosis are still unclear.Objective: To shed light on the mechanisms of RET-induced apoptosis, we searched for novel interactors of RET51.Design: The "split ubiquitin yeast two-hybrid system" was used with RET51 as bait against a human brain expression library.Results: We identified aryl hydrocarbon receptor-interacting protein (AIP), a cochaperone recently found mutated in pituitary adenoma patients, as a novel interactor of RET.We showed that RET interacts specifically with AIP both in mammalian cell lines and in vivo in the pituitary gland, regardless of the presence of pituitary adenoma-specific mutations.AIP and RET genes were sequenced in 28 pituitary adenoma, but no relevant mutations were found.In addition, we identified the proapoptotic domain of RET as responsible for the interaction with AIP.Finally, we demonstrated that the AIP-RET interaction does not require RET kinase activity or kinase-dependent signal transduction and that it prevents the formation of the AIP-survivin complex.Conclusions: The identification of the AIP-RET complex represents a starting point to study key cellular processes involved in RET-induced apoptosis.
Preliminary evaluation of a new extracorporeal liver support system in fulminant hepatic failure rats *Department of Medicine, University of California, Los Angeles and **Cedars Sinai Medical Center, Los Angeles
Journal: Hepatology (1995)

The aim of the present study was to characterise developmental changes in glutathione S-transferase (GST) isoforms expression and in glutathione conjugation capacity in intrasplenic liver tissue transplants. For this purpose, syngenic fetal liver tissue suspensions were transplanted into the spleens of adult male Fischer 344 rats. Three days, 1, 2, 4 weeks, 2, 4, 6 months and 1 year later, transplant-recipients and control animals were sacrificed and class α, μ and π GST isoforms expression and GST activities using the substrates o-dinitrobenzene and 1-chloro-2,4-dinitrobenzene were assessed in livers and spleens.In the hepatocytes of the adult livers no class π, but α distinct class α and μ GST expression was seen. The bile duct epithelia were class π GST positive. Fetal livers displayed almost no class α and μ, but a slight class π GST expression. The same pattern was seen in 3-day-old intrasplenic liver tissue transplants. Up to 2 weeks after surgery the class α and μ GST expression increased in the hepatocytes of the transplants, whereas the immunostaining for class π GST disappeared. No remarkable changes were seen thereafter.Normal conjugation capacities were observed with the livers of both groups of rats. Control spleens displayed only low GST activities. From 2 months after transplantation on activities were significantly higher in transplant-containing spleens than in respective control organs with a further increase up to one year after grafting.These results show that intrasplenically transplanted fetal liver cells proliferate and differentiate into mature cells displaying a GST expression pattern with respective enzyme activities similar to adult liver.