tbuckley/cabot-search huggingface dataset:
Erratum to “Enhanced in Vivo Selection of Bone Marrow Cells by Retroviral-Mediated Coexpression of Mutant O6-Methylguanine-DNA-methyltransferase and HOXB4”
Authors: Michael D. Milsom, Lorna B. Woolford, Geoffrey P. Margison, R. Keith Humphries, Leslie J. Fairbairn
Journal: Molecular Therapy (2005)

The percentages given for the PBC histograms in Fig. 5B, i–v, are incorrect. For the reader's convenience, the corrected figure appears here along with its legend. Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4Milsom et al.Molecular TherapyNovember, 2004In BriefTo attain therapeutic levels of gene-modified hematopoietic stem cells, it may be necessary in the majority of disorders to provide an in vivo selective advantage that facilitates the expansion of their numbers. A popular strategy to achieve in vivo selection has been to employ drug selection while coexpressing a transgene that conveys chemoresistance, such as O6-methylguanine-DNA-methyltransferase (MGMT). An alternate approach is to confer an enhanced proliferative potential upon gene-modified hematopoietic stem cells through the delivery of the homeobox transcription factor HOXB4. Full-Text PDF Open Archive
Oral Surg, Oral Med and Oral Path, St. Louis
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Pregnancy after renal replacement.
Journal: BMJ (1976)

salpingotomy.In so doing they collected from the literature some reports of the incidence of further pregnancies following salpingectomy with or without oophorectomy.One of these, as Mr Hawkins points out, was published from Liverpool.4If he reads this he will discover that it emanated from my own department and elaborated a previous preliminary communication by the same member of staff (Bender5), who followed up 264 cases of tubal pregnancy treated in various ways.The findings showed that salpingectomy was followed by pregnancy, intrauterine or ectopic, in 43 0,, of cases whereas salpingo-oophorectomy was followed by pregnancy in 57 ",, of cases.But it was made clear that the difference did no more than "suggest" that removal of the ovary of the affected side is some- times advantageous from the standpoint of subsequent fertility.As is emphasised in this article, and in others referred to by Mr Hawkins, the occurrence of pregnancy after the surgical treat- ment of tubal pregnancy is determined by many factors such as the age, parity, and intent for further childbearing of the woman concerned, as well as the particular procedure carried out and the reasons for its choice.
Radiology
Authors: Ronald G. Evens
Journal: JAMA (1992)

While reviewing the past year in diagnostic radiology, I was reminded of many important developments that have the potential to improve patient care. As Contempo authors are asked to restrict their discussions to only "key" advances likely to be of interest to readers in other specialties, I limit this review to four areas: magnetic resonance imaging (MRI), sonography, interventional radiology, and economic issues in diagnostic radiology. Magnetic resonance imaging continues to develop in multiple directions. Perhaps most exciting was a report that MRI can actually identify and map the areas of the human brain that are active during a variety of neurological functions.<sup>1</sup>If this is verified, MRI becomes a competitor to positron emission tomography as an imaging technique for identifying and analyzing higher brain function. Positron emission tomography technology is mature and well developed, and its ability to identify regions important to brain function is especially valuable. With
Yes, Time magazine, there is an ombudsman committee
Authors: R. Crawshaw
Journal: JAMA (1971)

Last year<i>Time</i>magazine ran a cover story bemoaning the sorry state of the medical profession (<b>93:</b>53-58, 1969). Among the rehashed complaints was the one about "there is no Ombudsman committee to help the patient in dealing with the profession." The Oregon Medical Association does have an Ombudsman committee, and it appeared that<i>Time</i>magazine had simply missed this bit of action in the far West. However, after writing<i>Time</i>, belatedly, a<i>Time</i>staff member replied, "You will be interested to know that we were aware of the programs being carried out by the Oregon Medical Association and had included mention of them in the first draft of our story—unfortunately, the reference had to be deleted later on because of space problems." Once again, truth suffered on the rack of some man's necessity. <h3>A Suggestion</h3> The purpose here is not to beat a dead horse, sometimes referred to as
Analytical and Theranostic Applications of Gold Nanoparticles and Multifunctional Nanocomposites: Erratum
Authors: Nikolai Khlebtsov, Vladimir Bogatyrev, Lev Dykman, Boris Khlebtsov, Sergey Staroverov, Alexander Shirokov, Larisa Matora, Vitaly Khanadeev, Timofey Pylaev, Natalia Tsyganova, Georgy Terentyuk
Journal: Theranostics (2013)

In our paper [1], the Figure 6 legend should be corrected as follows: (b) TEM image of the same bacteria after a special washing procedure and simultaneous labeling with a mixture of O-specific conjugates (50-nm Au-Ag nanocages + anti-LPS antibodies) and H-specific conjugates (15-nm GNPs + anti-PFL antibodies).
SIR WILLIAM BOWMAN (1816-1892)
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mollaret Meningitis
Authors: Barton F. Haynes
Journal: JAMA (1976)

Three cases of benign, recurrent meningitis of Mollaret demonstrated unusual aspects of this disease. Postpartum pituitary necrosis was an antecedent event in one case. A second case occurred in an otherwise healthy 82-year-old woman, and a third patient was thought to have<i>Histoplasma</i>meningitis. The pathophysiology of Mollaret meningitis remains an enigma, and the therapy consists of supportive care. (<i>JAMA</i>236:1967-1969, 1976)
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Authors: X. Qu
Journal: Journal of Clinical Investigation (2003)

Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no genetic evidence for a role of autophagy genes in tumor suppression. The beclin 1 autophagy gene is monoallelically deleted in 40–75% of cases of human sporadic breast, ovarian, and prostate cancer. Therefore, we used a targeted mutant mouse model to test the hypothesis that monoallelic deletion of beclin 1 promotes tumorigenesis. Here we show that heterozygous disruption of beclin 1 increases the frequency of spontaneous malignancies and accelerates the development of hepatitis B virus–induced premalignant lesions. Molecular analyses of tumors in beclin 1 heterozygous mice show that the remaining wild-type allele is neither mutated nor silenced. Furthermore, beclin 1 heterozygous disruption results in increased cellular proliferation and reduced autophagy in vivo. These findings demonstrate that beclin 1 is a haplo-insufficient tumor-suppressor gene and provide genetic evidence that autophagy is a novel mechanism of cell-growth control and tumor suppression. Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers.
Chronic diarrhea
Authors: D. J. Fleischli
Journal: JAMA (1967)

Dr. Donald J. Fleischli: This 47-year-old woman entered the hospital complaining of intermittent cramps and diarrhea during the past year. A typical attack lasted three to four days and consisted of five to ten episodes of severe lower-abdominal cramps and urgency, relieved promptly by defecation, which often produced only small amounts of loose watery stool containing mucus but no blood. Between attacks she was asymptomatic for periods of two to three weeks. She had been in Mexico nine months prior to admission and in Puerto Rico one week prior to admission, however her complaints antedated these trips. Results of physical examination were normal. There was no abdominal tenderness. White blood cell count, hemoglobin level, and urinalysis findings were normal. The erythrocyte sedimentation rate was elevated. Sigmoidoscopy revealed several 5mm discrete shallow ulcers near the rectosigmoid junction. Several stool examinations gave negative results for blood, ova, and parasites. A later specimen
Public health is local
Authors: None The Lancet Public Health
Journal: The Lancet Public Health (2017)

"Public health is local, and similarly local information is required to increase awareness among residents and policy makers alike of the unique challenges facing communities", conclude Laura Dwyer-Lindgren and colleagues in an Article published in this issue of The Lancet Public Health. In their study investigating variation in life expectancy and mortality by cause among neighbourhoods in King County, WA, USA, between 1990 and 2014, the Global Burden of Disease Study group applies latest small area estimation methods to mortality data in King County—a county that includes the city of Seattle, 2 million individuals, and where life expectancy is among the highest in the USA.
Genetic counseling and the physician
Authors: H. T. Lynch
Journal: JAMA (1970)

Genetic counseling should be an integral part of medical care when hereditary factors are either suspected or actually proven. In 1964, the World Health Organization Expert Committee on Human Genetics<sup>1</sup>recommended increased training of medical personnel in medical genetics, with particular emphasis on genetic counseling. Again in 1968,<sup>2</sup>it was emphasized that "education of the general practitioner in medical genetics is most important. Teaching should be given at both the preclinical and clinical levels of medical education. It is equally important that medical genetics be dealt with in postgraduate education in refresher courses." Genetic specialty clinics are not the answer since too few exist to meet the pressing demands for counseling. Furthermore, since our approach to genetic counseling entails diagnosis, therapy, and prognosis of the patient and of his relatives at genetic risk, we feel that the continuity of the overall plan will be best assured when the
PHYSICAL EXAMINATION OF FOOD HANDLERS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1270: Human P-glycoprotein-mediated drug transport: Two aromatic residues in the drug-binding pocket are critical for function
Authors: Megumi Murakami, Eduardo E. Chufan, Sabrina Lusvarghi, Suresh V. Ambudkar
Journal: Cancer Research (2019)

Abstract P-glycoprotein (P-gp) is an efflux pump that transports cytotoxic agents, thereby affecting the pharmacokinetics of many drugs and conferring resistance to chemotherapeutic agents in many cancers. P-gp utilizes energy from ATP hydrolysis for the efflux of a number of amphipathic natural products or small molecule anticancer drugs. However, the nature and number of translocation pathways for the transport of substrate-drugs by P-gp is not yet known. Previously we showed that substitution of certain aromatic residues in the drug-binding pocket switched the modulation of ATPase activity from inhibition to stimulation. Molecular modeling studies led to identification of two T-shaped structural motifs formed by F728/Y310 and F978/Y953. In this study, we demonstrate that substitution of all four residues of the T-shaped structural motifs with alanine (Y310A/F728A/Y953A/F978A) results in complete loss of transport of ten fluorescent substrates. Furthermore, alanine substitution of one or two of these residues revealed that when F728 and F978 are both substituted, this has the greatest impact on the binding and/or translocation of drug-substrates. ATPase assays and in silico analyses were performed to gain insight into interactions of these residues with substrates and modulators. These results indicate that the F728 and F978 residues together are critical to maintaining the conformation of the drug-binding pocket for binding and translocation of substrates by P-gp. Citation Format: Megumi Murakami, Eduardo E. Chufan, Sabrina Lusvarghi, Suresh V. Ambudkar. Human P-glycoprotein-mediated drug transport: Two aromatic residues in the drug-binding pocket are critical for function [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1270.
The Scientific Exhibit
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Memphis State University rubella outbreak. An example of changing rubella epidemiology
Authors: B. Guyer
Journal: JAMA (1974)

During the spring of 1973, ninety-six cases of rubella occurred at Memphis State University. The epidemic remained confined to the University and did not involve elementary school children, who are the traditional source of infection for young adults. The epidemic occurred despite immunity levels of more than 80% in both the elementary school and college students. This outbreak and others recently reported in high schools and colleges suggest that rubella in these age groups may be a source of exposure for pregnant women.
MEDICAL GENETICS
Authors: Victor A. McKusick
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
State-of-art drug identification laboratories play increasing role in major athletic events
Authors: V. Cowart
Journal: JAMA (1986)

WHEN ATHLETES GATHER next summer in Indianapolis for the Pan-American Games, which are often seen as a preview of the Olympic Games, the Sports Medicine Drug Identification Laboratory at Indiana University Medical Center in Indianapolis will offer a first look at a new state-of-the-art facility that can strike fear into the heart of any athlete who has been experimenting with banned substances. At the 1983 Pan-American Games in Caracas, Venezuela, the disqualifications and withdrawals from competition that occurred when it became obvious that the laboratories could indeed discern who was using drugs marred the image of the event and [ill]ocused attention on the issue of drug use by amateur athletes. (Because many athletes feel they all have been unfairly tarred with the brush of drug use, it should be noted that the actual prevalence detected in Caracas was about 5%, as opposed to the 1% prevalence at the 1984 Olympic
Effect of repeated whole blood donations on serum immunoreactive erythropoietin levels in autologous donors
Authors: T. S. Kickler
Journal: JAMA (1988)

The effect of repeated phlebotomy on serum immunoreactive erythropoietin levels was studied prospectively in 69 autologous blood donors. At the time of the initial phlebotomy, 11 men (33%) and two women (6%) were anemic; during the course of blood donations, anemia (defined as a hematocrit &lt;0.41 for men and &lt;0.36 for women) developed in an additional 17 men (71%) and 14 women (45%). Although there was an increase in the level of serum immunoreactive erythropoietin with successive phlebotomies, the increase was not substantially out of the normal range. The lack of an erythropoietic response to repeated phlebotomies in association with the small increment in the serum erythropoietin level was not due to iron deficiency, since the level of red-cell free protoporphyrin did not increase in these patients. We conclude that within the hematocrit range permissible for autologous blood donation, the degree of anemia experienced is insufficient to initiate an adequate increase in erythropoietin production; as a consequence, mild anemia develops in a majority of donors, and the volume of blood donated is inadequate to meet their operative needs. (<i>JAMA</i>1988;260:65-67)
Hyperkalemia
Authors: Biff F. Palmer, Deborah J. Clegg
Journal: JAMA (2015)

A 64-year-old man with type 2 diabetes and hypertension has begun to experience generalized weakness. His laboratory results show a serum potassium level of 6.6 mEq/L (reference range, 3.5-5.0). How do you interpret the results?
MEDICAL PROGRESS.
Journal: JAMA (1883)

<h3>Coloring Matters of the Urine in Microscopic Examinations.</h3> —Dr. C. Méhn. (<i>Annales des Maladies des Organes Génito-Urinaires</i>.) Some five years ago Dr. Méhn suggested the use of a saturated solution of ammonium sulphate to precipitate urobiline and other biliary pigments from slightly acid solutions by which process he readily separated the pathological coloring matters of the urine, also extracting the fatty matters from the so-called chylous urine. The present article treats of a method of re-dissolving these substances to facilitate the examination of urinary sediments. For this purpose he uses the ordinary sodium phosphate of pharmacy, in a cold saturated solution, which dissolves readily the ordinary bile pigments which can anew be precipitated by the ammonium sulphate. To relieve the anatomical elements of the pigment which obscures them, a few drops of this solution added cold, in a few moments re-dissolves the pigment and the urates so as to allow