tbuckley/cabot-search huggingface dataset:
Circulation, New York
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
182 LIVER STIFFNESS ACCURATELY PREDICTS PORTAL HYPERTENSION RELATED COMPLICATIONS IN PATIENTS WITH CHRONIC LIVER DISEASE: A PROSPECTIVE STUDY
Authors: B. Procopet, M.A. Robic, S. Mètivier, J.M. Peron, J. Selves, J.P. Vinel, C. Bureau
Journal: Journal of Hepatology (2011)
Acceptation des patients de retarder la résection de polypes diminutifs: résultats d’un questionnaire multicentrique
Journal: Endoscopy (2018)

Le risque de dégénérescence des polypes diminutifs (PD), définis par une taille inférieure à 5 mm est faible. La stratégie de résection systématique lors de coloscopie est donc discutée notamment sur le plan coût-efficacité par rapport à une résection uniquement des polypes progressifs. Une étude randomisée est ainsi justifiée, mais devra inclure un grand nombre de patients. Peu est connu sur le ressenti des patients sur le fait de laisser en place des polypes même de petite taille.
Report of Typhoid Fever.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluating drugs: a new approach.
Journal: BMJ (1977)

observers were sceptical of its value.Recently attention has been shifted to haemodialysis using a polyacrylonitrile membrane (which differs from standard cuprophane and cellophane membranes in allowing through compounds with molecular weight of up to 15 000).Two groups have reported results so far.In Paris Opolon"7 has treated 39 patients with coma due to fulminant hepatic failure, and, though 17 recovered consciousness, only nine survived.The group at King's College Hospital'8 has treated 24 patients: nine recovered consciousness and eight survived.At present, therefore, we have no convincing evidence that any form of artificial liver support is able to increase the chances of survival in fulminant hepatic failure.It has been suggested that treatment should be started before grade IV coma supervenes, but such patients have, of course, a much better prognosis and the results of different types of treatment will be difficult to evaluate without a controlled trial.Meantime the best hope for survival is offered by scrupulous attention to the details of management in an intensive care unit accustomed to treating these patients.
Late diagnosis of frontal meningiomas.
Journal: BMJ (1988)

part in autoaggressive diseases, particularly in inflammatory joint disease in predisposed people, so the association between HIV infection and inflammatory joint disease is no longer a surprise.Moreover, the data, although preliminary, may shed some light on the immunopathogenesis of HIV infection and autoaggressive disorders.The investigation of y interferon concentrations in the serum of people with HIV infection has to be extended.The increased y interferon concentrations in HIV infection suggest the presence of pre- activated cellular immunity despite severe immunodeficiency.Thus in these patients im- munodeficiency is, in general, not the result of diminished release of y interferon by T lymphocytes but is caused by persistent exposure ofcells to various immunogens.The reduced ability of T cells in AIDS to release y interferon is, therefore, restricted to in vitro studies.4
Retinal Prosthesis
Authors: James D. Weiland, Wentai Liu, Mark S. Humayun
Journal: Annual Review of Biomedical Engineering (2005)

▪ Abstract Retinal prostheses represent the best near-term hope for individuals with incurable, blinding diseases of the outer retina. On the basis of the electrical activation of nerves, prototype retinal prostheses have been tested in blind humans and have demonstrated the capability to elicit the sensation of light and to give test subjects the ability to detect motion. To improve the visual function in implant recipients, a more sophisticated device is required. Simulations suggest that 600–1000 pixels will be required to provide visual function such as face recognition and reading. State-of-the-art implantable stimulator technology cannot produce such a device, which mandates the advancement of the state of the art in areas such as analog microelectronics, wireless power and data transfer, packaging, and stimulating electrodes.
Macular Degeneration
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The clinical significance of p53 gene mutation in hepatocellular carcinomas from Japan
Authors: H HAYASHI
Journal: Hepatology (1995)

To clarify the clinical significance of the mutation of p53 gene in hepatocellular carcinoma (HCC), 90 resected specimens from Japanese patients were assayed using a polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. p53 mutations were detected in 25 cases (27.8%) at exons 4, 5, 6, 7, and 8, and the most frequent region of the mutation was at exons 5 and 7. No statistically significant correlation was observed between the p53 mutations and the clinical features except for the preoperative alpha-fetoprotein (AFP) level (P < .05). According to the pathological features, prognostic factors, such as size of the tumor, vascular invasion, fibrous capsule infiltration, and intrahepatic metastasis, showed no relationship to the existence of the mutation. However, p53 mutations were significantly associated with the degree of differentiation of HCC; that is, the mutation was found in 19 cases of 53 poorly differentiated HCCs (35.9%) and 2 of 3 cases of anaplastic HCCs (66.7%). The presence of p53 mutations was associated with a shortened cancer-free survival (P < .001, by log rank test) and a shortened survival (P <.05). A multivariate analysis by the Cox regression analysis showed that the p53 mutations were an unfavorable prognostic factor related to recurrence (P < .005), which is especially significant within the first postoperative year. These results suggest that the mutations of p53 gene of HCC might be an independent prognostic predictor to help in the selection of candidates who should undergo more intensive postoperative treatment.
AMA-RPS Resident Workforce Resolutions
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-005 An exploration of the health and social needs of people living with inflammatory bowel disease: a metasynthesis
Authors: K Kemp, J Griffiths, K Lovell
Journal: Gut (2012)

<h3>Introduction</h3> The Inflammatory Bowel Disease Questionnaire and the Rating Form for IBD patient9s Concerns, are widely used measures in IBD but fail to capture the essence of living with IBD from the patient9s perspective. To deliver patient centred care it is imperative that we have an understanding of the experience of living with IBD. This study aimed to synthesise the findings of qualitative papers that explored the health and social needs of patients living with IBD. <h3>Methods</h3> A systematic literature search was conducted in MEDLINE, PsychInfo, EMBASE, CINAHL, British Nursing Index via the OVID platform to August 2010. Search filters developed by the Hedges database, McMaster University Health Information Research Unit and Kathryn Nesbit, Edward G Milner Library, University of Rochester, were adapted to aid the search. 1395 papers were generated by the preliminary search. Qualitative studies which explored the phenomena of living with IBD, English language and sample population adults &gt;16 years were included. Study eligibility judgements and data extraction were independently completed by the authors. The papers were quality appraised using the Critical Appraisal Skills Programme. Synthesis was achieved by comparing the themes and findings of each study with one another to identify 1st order constructs. Repeated comparison between the papers revealed the similarities and differences, which led to 2nd order constructs and the new interpretation of the synthesised studies. <h3>Results</h3> Six papers and one unpublished thesis were included, all from Western countries, one study included patients from an immigrant background. Combined sample of the studies was only 86 patients to describe the phenomena of living with IBD. First iteration of synthesis identified 16 themes, 2nd iteration synthesised these into three main constructs: “detained by the disease”; “living in a world of disease”; “wrestling with life”. “Detained by the disease” is the fear of incontinence, and the behaviour the patients displays as a result of this. Social isolation and missing out on life events all serve to “pull” the patient back from normal living. “Living in a world of disease” is living with the fear of a long term condition.“ Wrestling with life” is the “push” to continue normal living. <h3>Conclusion</h3> People with IBD endure many daily challenges, stress, pain, fighting for control. The combined impact of living with IBD is the tension they live with. The value of metasynthesis is the interpretation of all of the synthesised studies to provide a global representation of living with IBD: “Pushed and pulled: a compromised life”, people living with IBD experience a constant conflict throughout their lives, they push to be normal but IBD pulls them back. <h3>Competing interests</h3> None declared.
Glaucoma
Authors: Miles A. Galin, Philip Zweifach
Journal: New England Journal of Medicine (1962)

(Concluded)*Systemic (Oral) TherapyThe second major attack in the medical treatment of glaucoma has been the use of agents that decrease the production of aqueous humor. The most widely used group of drugs with this effect are those that inhibit carbonic anhydrase. This enzyme, which catalyzes the reaction of carbon dioxide and water to form carbonic acid, plays an important part in many biologic secretory processes, including gastric secretion, renal absorption and carbon dioxide carriage in the bloodstream. Friedenwald believed that carbonic anhydrase had an indirect role in the secretion of aqueous by providing buffer bicarbonate. A more active . . .
<i>Erratum:</i> Vol. 68, No. 33
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

In the report "Characteristics of a Multistate Outbreak of Lung Injury Associated with E-cigarette Use, or Vaping -United States, 2019," on page 860, in the first paragraph, the ninth sentence should have read "Among 514 patients with information on substances used in e-cigarettes, or vaping products, in the 3 months preceding symptom onset, 76.9% reported using THC-containing products, and 56.8% reported using nicotine-containing products; 36.0%reported exclusive use of THC-containing products, and 16.0% reported exclusive use of nicotine-containing products."Also on page 860, in the last paragraph, the third sentence should have read "Among a subset of 514 patients (63.8%) for whom information on substances used in e-cigarettes, or vaping, products was available, 395 (76.9%) reported using THC-containing products, and 292 (56.8%) reported using nicotine-containing products in the 3 months preceding symptom onset; 210 patients (40.9%) reported using both THCcontaining and nicotine-containing products, 185 (36.0%) reported exclusive use of THC-containing products, and 82 (16.0%) reported exclusive use of nicotine-containing products."
Invasive Infection With Streptococcus iniae—Ontario, 1995-1996
Journal: JAMA (1996)

During December 1995-February 1996, four cases of a bacteremic illness (three accompanied by cellulitis and the fourth with infective endocarditis, meningitis, and probable septic arthritis) were identified among patients at a hospital in Ontario. Streptococcus iniae, a fish pathogen not previously reported as a cause of illness in humans, was isolated from all four patients. All four patients were of Chinese descent had a history of preparing fresh, whole fish; three patients for whom information was available had had an injury associated with preparation of fresh, whole fish purchased locally. This report summarizes information about these cases and presents preliminary findings of an ongoing investigation by health officials in Canada, which suggests that S. iniae may be an emerging pathogen associated with injury while preparing fresh aquacultured fish.
Vaccines
Authors: Allan D. Friedman
Journal: JAMA (1989)

In the century since laboratory development of vaccines began, there has been an explosion of knowledge related to methods of inducing immunity and vaccine development. Along with changes in public sanitation and hygiene, the development of vaccines has dramatically affected the spectrum and frequency of communicable diseases that we see today. Even during the past decade, vaccine research and development have progressed at a rapid pace, and over the horizon is potentially an equally impressive amount to yet be learned. Young clinicians and physicians in training tend to accept the value of vaccines but lack the firsthand knowledge to truly appreciate their dramatic impact on health, especially children's health. In<i>Vaccines</i>, Plotkin and Mortimer allow us to explore the history and science of existing vaccines and then give us a glimpse into the future of vaccine development. The book is a 633-page comprehensive text. Subjects covered include existing licensed vaccines,
Effect of Accessory Pulmonary Blood Flow on Survival After the Bidirectional Glenn Procedure
Authors: Richard D. Mainwaring, John J. Lamberti, Karen Uzark, Robert L. Spicer, Mark W. Cocalis, John W. Moore
Journal: Circulation (1999)

Background —The bidirectional Glenn procedure (BDG) is used in the staged surgical management of patients with a functional single ventricle. Controversy exists regarding whether accessory pulmonary blood flow (APBF) should be left at the time of BDG to augment systemic saturation or be eliminated to reduce volume load of the ventricle. The present study was a retrospective review of patients undergoing BDG that was conducted to assess the influence of APBF on survival rates. Methods and Results —From 1986 through 1998, 149 patients have undergone BDG at our institution. Ninety-three patients had elimination of all sources of APBF, whereas 56 patients had either a shunt or a patent right ventricular outflow tract intentionally left in place to augment the pulmonary blood flow provided by the BDG. The operative mortality rate was 2.2% without APBF and 5.4% with APBF. The late mortality rate was 4.4% without APBF and 15.1% with APBF. Actuarial analysis demonstrates a divergence of the Kaplan-Meier curves in favor of patients in whom APBF was eliminated ( P &lt;0.02). One hundred seven patients have subsequently undergone completion of their Fontan operation, so the actuarial analysis includes the operative risk of this second operation. Conclusions —The results suggest that the elimination of APBF at the time of BDG may confer a long-term advantage for patients with a functional single ventricle.
Y to X translocation in a woman with reproductive failure. A new rearrangement
Authors: G. Khudr
Journal: JAMA (1973)

A translocation of the Y to the X chromosome was found in a woman who had habitual abortion. Endocrinologic studies disclosed only an abnormal elevation of her prolactin and thyroid-stimulating hormone (TSH) levels. Phenotypically, she has a rare form of dwarfism and abnormal dermatoglyphic patterns. This new chromosomal rearrangement in the human has several implications.
Roentgen Diagnosis of Diseases of Bone
Authors: Howard L. Steinbach
Journal: JAMA (1974)

This second edition, appearing six years after the first, has been expanded into two volumes that contain 1,265 illustrations, of which approximately 700 are new. The quality of the roentgenographic reproductions is an outstanding feature of the book. All illustrations are large and many fill an entire page. The legends are succinct but explanatory and allow the illustrations to be viewed as an atlas, without reference to the text. The descriptions of disease, when appropriate, include the name and synonyms, followed by an introduction, short descriptions of etiology, clinical, laboratory, and pathologic features, and an extensive review of roentgenographic features. Bone lesions that result from different diseases may appear similar on roentgenograms and these necessitate referral to clinical observations for diagnosis. The pertinent information is presented and an extensive bibliography includes recent articles on all aspects of skeletal disease. The relative space devoted to illustrations, compared with the text, is
Effect of Toxaphene on Pyruvic and Lactic Acid Levels in the Rat
Authors: David B. Peakall
Journal: Environmental Health Perspectives (1979)

Rats were given a single dose of toxaphene (120 mg/kg equilavent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. No alterations of levels of pyruvic or lactic acid in blood plasma were observed. In a second experiment, rats were given 2.4 mg/kg daily and sacrificed at 1, 3, and 6 months, and again no alterations of pyruvic or lactic acid levels were found. It is concluded that observed alterations of the activity of lactic acid dehydrogenase induced by toxaphene do not give rise to physiological changes in unstressed rats.
Vertebral osteomyelitis due to Pseudomonas in the occasional heroin user
Authors: R. W. Light
Journal: JAMA (1974)

VERTEBRAL osteomyelitis is a recognized complication of heroin addiction.<sup>1,2</sup>The following two cases of vertebral osteomyelitis resulting from<i>Pseudomonas</i>infection are presented to emphasize that this entity can occur in patients who have used heroin only occasionally. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 24-year-old man had low back pain of one month's duration. He admitted having twice used heroin intravenously, most recently five months before admission. Physical examination gave normal results except for pain localized in the L3-4 area of the spine and a positive straightleg-raising test. The patient had occasional evening temperature elevations between 37.8 and 38.3 C (100 and 101 F). The erythrocyte sedimentation rate was persistently elevated above 30 mm/hr; on the other hand, he had no leukocytosis, and six blood cultures were negative. Initial lumbosacral spine roentgenograms were normal. Two weeks later, however, narrowing of the L3-4 intervertebral disk space was noted. Cultures of tissue
Stent supported carotid artery angioplasty. The beneficial effect of cerebral protection Michel Henry, Christos KLONARIS, Max AMOR, Isabelle HENRY, Isabelle MASSON, Bernard FOLIGUET, Serge KOWNATOR, Francois LUIZY, Edmond LE BORGNE, Michele HUGEL. Polyclinique d'Essey-les-Nancy, ESSEY-LES-NANCY, France
Journal: Journal of the American College of Cardiology (2001)
NCCN NewsNew NCCN Resources for Non-Hodgkin's Lymphomas Empower Patients to Make Informed Treatment DecisionsNew NCCN Imaging Appropriate Use Criteria Resources Help Assure Patients Receive Best Cancer Care AvailableNCCN Awards Research Grants to Eight Investigators to Support Clinical and Preclinical Studies of Mirvetuximab Soravtansine in Various CancersNew Education Materials From NCCN Empower Patients with Rare Lymphoma
Journal: Journal of the National Comprehensive Cancer Network (2016)
ADP-antagonists therapy added to aspirin prior to coronary intervention markedly attenuates the risk associated with baseline CRP status Mark A. Robbins, Derek P. Chew, Deepak L. Bhatt, Debabrata Mukerjee, Marco Roffi, Jakob P. Schneider, Eric J. Topol, Stephen G. Ellis. Cleveland Clinic Foundation, Cleveland, OH
Journal: Journal of the American College of Cardiology (2001)