tbuckley/cabot-search huggingface dataset:
IMMUNITY AGAINST CROUPOUS PNEUMONIA.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship of human papillomavirus type to grade of cervical intraepithelial neoplasia
Authors: O. Lungu
Journal: JAMA (1992)

<h3>Objective.</h3> —To determine the relationship of human papillomavirus (HPV) type to grade of cervical intraepithelial neoplasia (CIN) in a large series of cases. <h3>Design.</h3> —A survey of HPV types in CIN lesions detected using a new, highly accurate method for typing HPV that is based on restriction fragment length polymorphism analysis of amplimers produced during polymerase chain amplification of the conserved L1 region of HPV using consensus primers. <h3>Setting.</h3> —Private gynecologists' offices and inner-city colposcopy clinics. <h3>Patients.</h3> —A convenience sample of 276 HPV DNA-positive cervical biopsy specimens or samples from patients undergoing colposcopy for abnormal Papanicolaou smears. <h3>Intervention.</h3> —None. <h3>Main Outcome Measure(s).</h3> —Human papillomavirus type(s). <h3>Results.</h3> —Cervical intraepithelial neoplasia 1 lesions were relatively heterogeneous with regard to associated HPV types. Nineteen percent of CIN 1 lesions were associated with HPV types 6 or 11; 29% contained HPV types 16,18, or 33; and 19% were associated with "novel types" of HPV. It was also found that 22% of CIN 1 lesions were associated with more than one HPV type. In contrast to CIN 1, both CIN 2 and CIN 3 were relatively homogeneous with regard to associated HPV types. Eighty-eight percent of CIN 2 and 3 lesions contained HPV types 16, 18, or 33. Unlike CIN 1 lesions, which often contained multiple types of HPV, only 7% of CIN 2 and 3 lesions were associated with multiple HPV types. <h3>Conclusions.</h3> —Cervical intraepithelial neoplasia should be classified into two separate categories—low-grade and high-grade CIN. Since only 29% of low-grade lesions are associated with HPV types 16, 18, or 33, HPV type could potentially play a role in determining the most appropriate clinical management of patients with low-grade CIN. However, prospective follow-up studies of lesional behavior based on HPV type are required before clinical recommendations can be made. (JAMA. 1992;267:2493-2496)
ABSTRACTS
Authors: STANFORD WESSLER
Journal: Circulation (1962)

The effect on cardiac rhythnii of the rapid transient hypocalcemnia following the intravenous administration of trisodiuini ethylenediamine tet- racetate (Na3EDTA) was studied 92 times in 66 patients.The patients ranged in age from 9 months to 90 years.Twelve patients had no evi- dence of heart disease; 36 showed evidences of digitalis intoxication; and 18 had arrhythmias but were not receiving digitalis.In most of thle dioitalis-intoxicated patients Na3EDTA was ef- fective, permanently or transiently, in reversing the arrhythmia.Normnal sinus rhythm in this group was continued or reinstituted by the addi- tional therapeutic use of oral potassiumn chloride and the withdrawal of digitalis.In all 14 pa- tients who also had subjective complaints re- ferable to digitalis intoxication these symlptoms were relieved by Na3EDTA.The drug was less reliable in correcting the arrhvthmias present in those patients not receiving digitalis.In six patients refractorv to Na EDTA autopsy r'- vealed patholovy of the conduction system, which could have accounted for the arrhythmia or con- duction defect.The findings indicated that in adults a minimum of 3.0 Gin. of Na3EDTA should be given within 12 minutes before a result is con- sidered negative.Forty per cent of the patients developed armn pain, eircumoral paresthesia, and apprehension during the infusion.The arm pain 958 was readily relieved by massage and warm packs and the other symptoms could be relieved by slowing the rate of infusion.SAGALL Friese, G., and Thorspecken, R.: Treatment of A-V Conduction Disturbances of the Heart.Germian M. Monthly 6: 277 (
Emergency Medical Service
Authors: William F. Renner
Journal: JAMA (1974)

GOVERNMENTAL decisions at the national level to grant a high priority to the promotion of emergency medical services (EMSs), backed by appropriate funding, have catalyzed revolutionary changes in the concept of emergency medical care in the United States. The Emergency Medical Services Systems Act of 1973 is providing $185 million over a three-year period for EMS improvements throughout the country in a program being administered by the Department of Health, Education, and Welfare (HEW). The Federal Communications Commission (FCC) has sponsored a study by the Interdepartment Radio Committee in coordination with representatives of the FCC and the medical community on "Communications in Support of Emergency Medical Services" and a second study by Advanced Technology Systems of Arlington, Va, under FCC contract, on "Rule Changes Required for Emergency Medical Communications." The FCC now is prepared to adopt rules changes based on recommendations from these studies that will facilitate the establishment of
Iron, Radiation, and Cancer
Authors: Richard G. Stevens, Donald R. Kalkwarf
Journal: Environmental Health Perspectives (1990)

Increased iron content of cells and tissue may increase the risk of cancer. In particular, high available iron status may increase the risk of a radiation-induced cancer. There are two possible mechanisms for this effect: iron can catalyze the production of oxygen radicals, and it may be a limiting nutrient to the growth and development of a transformed cell in vivo. Given the high available iron content of the western diet and the fact that the world is changing to the western model, it is important to determine if high iron increases the risk of cancer.
NORTH OF ENGLAND DERMATOLOGICAL SOCIETY
Journal: British Journal of Dermatology (1938)

British Journal of DermatologyVolume 50, Issue 12 p. 661-666 NORTH OF ENGLAND DERMATOLOGICAL SOCIETY First published: December 1938 https://doi.org/10.1111/j.1365-2133.1938.tb10449.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume50, Issue12December 1938Pages 661-666 RelatedInformation
Letter: Electrocardiographic effects of marihuana
Authors: M. H. Wendkos
Journal: JAMA (1973)

<h3>To the Editor.—</h3> With respect to the results of their study, Kochar and Hosko (225:25, 1973) found that after high doses of Δ-9-tetrahydrocannabinol, there was a reduced amplitude of the T-wave associated with S-T elevation in subject 1; a flattening of the T-wave without S-T-segment change in subject 2; and an absence of T-wave change in the remaining five subjects. Moreover, from the reproductions of the electrocardiograms, it is possible to ascertain the nature of the changes in subject 1, which were those the authors had particularly considered a justification for their claim that marihuana may possess a cardiotoxic property. However, so far as I can judge, even though the race of the subject was not mentioned, the findings (equivalent persistent S-T elevations throughout and slight variations in the form of the T-wave) constitute characteristic traits of the "normal S-T variant."<sup>1</sup>The matter of race was introduced, because in
A CLINICAL STUDY OF ULCERATIVE COLITIS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treating the brain by cingulotomy
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wissenschaftliche Forschungsberichte. Naturwissenschaftliche Reihe
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful bronchial artery embolization for refractory esophageal bleeding after failed endoscopic therapy
Authors: E. Kim, J. Lee, J. Sung, S. Kang, J. Kim, H. Moon, B. Lee, S. Kim, H. Jeong
Journal: Endoscopy (2010)

A 51-year-old man with chronic alcoholism was admitted to the emergency unit with hematemesis (750 mL). Emergency endoscopy revealed active bleeding from a longitudinal laceration in the lower esophageal wall. The laceration was approximately 3.5 cm long and located 35 cm from the incisor teeth ([Fig. 1]). Despite the application of more than 30 hemoclips and several rubber bands, bleeding was not controlled. As he was hemodynamically unstable, a transfemoral angiogram was performed to find the bleeding artery. The celiac angiogram showed that the left gastric or other arteries did not supply the area being clipped. We found dye leakage from a small branch of the right bronchial artery ([Fig. 2 a]). We embolized the bronchial artery with two 2-cm-long helical coils (Hilal Embolization Microcoil™, Cook, Bloomington, Indiana, USA). A follow-up angiogram revealed an occluded bronchial artery with no leakage ([Fig. 2 b]). Follow-up endoscopy 3 days later showed a healed ulcer at the laceration site ([Fig. 3]). The patient was discharged without further complications.
A Manual of Bacteriology.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polyvinyl Chloride
Authors: Ronald J. Barr
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The recent discovery of the association of polyvinyl chloride with primary hemangiosarcomas of the liver has received much publicity.<sup>1-3</sup>The systematic detection program as outlined by Makk et al<sup>4</sup>is certainly a step in the right direction in identifying the population at risk; however, as mentioned, there is as yet no specific chemical abnormality that could be used as an indicator in screening tests. Carcinoembryonic antigen and α-fetoprotein determinations have been negative in all cases of hemangiosarcomas, as opposed to hepatocellular carcinomas where they have been quite useful.<sup>5</sup> Recently, we performed an autopsy in a case of proved primary hemangiosarcoma of the liver. (The case was referred to the Center for Disease Control.) We would like to report a finding that we think could perhaps be used in an early detection system. The production of sulfated acid mucopolysaccharides is characteristic of malignant vascular tumors
New program to SCOPE out resistant organisms
Authors: C. Marwick
Journal: JAMA (1995)

SEVERAL INSTITUTIONS have volunteered to become part of a new effort to keep antibiotic-resistant organisms from becoming a 20th-century version of long-past plagues. Starting January 1, a program called Surveillance and Control of Pathogens of Epidemiologic Importance (SCOPE) went into effect. This national network is designed to track resistant pathogens and be an early-warning system for the health care community. It was set up by the University of Iowa College of Medicine, Iowa City, in collaboration with Lederle Laboratories, Wayne, NJ. The objective is to help hospitals control resistant infections by identifying them early. SCOPE is the largest nongovernmental surveillance program and the first combined effort of industry, academe, and hospitals to track microbial resistance. Data collected at 48 sentinel hospitals will be used for nationwide projections and identification of newly resistant strains. A system such as this is badly needed, says Richard P. Wenzel, MD, director of general medicine
Editorial: Focus on cutaneous host-defense failure in transplant recipients
Authors: E. M. Hersh
Journal: JAMA (1974)

The current article by Koranda et al (<i>JAMA</i>p 419) focuses mainly on host-defense failure and its cutaneous manifestations in transplant recipients. At most transplant centers, these patients daily receive orally administered prednisone and azathioprine to maintain their grafts. This regimen is usually administered in doses and according to a schedule that suppresses several aspects of host defense including granulocyte numbers and exudation, local mononuclear inflammatory responses, phagocytosis and intracellular killing of microorganisms, and delayed hypersensitivity as well as graft rejection.<sup>1</sup> Thus, it is not surprising that while organ graft rejection is often prevented, host defenses (systemic as well as cutaneous) are considerably impaired, resulting in an increased incidence of wound infections, verrucae, herpes simplex, herpes zoster, tinea versicolor, and cutaneous malignant neoplasms. In each of these instances, except for bacterial infections, the main host-defense factor is cell-mediated immunity and is based on the activity of thymus-derived or "T"
The Current Use of Studies on Promoters and Cocarcinogens in Quantitative Risk Assessment
Authors: J. F. Stara, D. Mukerjee, R. McGaughy, P. Durkin, M. L. Dourson
Journal: Environmental Health Perspectives (1983)

Several of the priority pollutants discussed in EPA's Ambient Water Quality Criteria documents have been reported to have promotion or cocarcinogenic activity. For example, phenol appears to have tumor-promoting activity in mice when repeatedly applied after initiation with either 7,12-dimethyl-1,2-benzanthracene (DMBA) or benzo(a)pyrene (BaP). Similarly, it has been reported that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent promoter of liver tumors as well as a cocarcinogen. However, in developing guidelines to derive ambient water quality criteria, it became apparent that satisfactory approaches had not been developed for using promotion/cocarcinogen data in human health risk estimation, nor were available promotion and/or cocarcinogen data on individual chemicals strong enough to permit a defensible quantitative risk estimation, if such approaches had existed. For this reason, the criteria derived for pollutants with reported promotion/cocarcinogenic activities were based on approaches for carcinogenic (e.g., TCDD), toxic (e.g., fluoranthene) or organoleptic effects (e.g., 2,4-dichlorophenol). Nonetheless, with advances in studies on both the biological mechanisms and dose/response patterns of promoters and cocarcinogens, it may be possible to develop a scientifically valid quantitative approach to use this type of data for derivation of ambient water quality criteria or other risk assessments. Some progress toward this goal and the problems associated with this effort are discussed.
Orthopedic Surgery
Authors: Otto E. Aufranc, Joseph S. Barr, Thornton Brown, Eugene E. Record
Journal: New England Journal of Medicine (1957)

Joint ReconstructionIt is a maxim in orthopedic surgery that a joint solidly fused in proper position is superior to a painful joint with limited motion. For this reason, arthrodesis is the procedure favored by a number of surgeons when they are dealing with nonarticular painful joint disease or disability. It is the first choice in joint tuberculosis with osseous involvement and in chronic sepsis or injury in which there is joint dysfunction accompanied by muscle weakness and extensive soft-tissue scarring. But complete loss of motion of any of the major joints has obvious disadvantages, which must be weighed and . . .
Overall survival with everolimus, sunitinib, and placebo for advanced pancreatic neuroendocrine tumors: A matching-adjusted indirect comparison of randomized trials.
Authors: James Signorovitch, Elyse Swallow, Evan Kantor, Xufang Wang, Peter Metrakos
Journal: Journal of Clinical Oncology (2012)

237 Background: Everolimus and sunitinib are approved in the US and EU for treating advanced pancreatic neuroendocrine tumors (pNET). No randomized trial has directly compared these treatments for pNET. This study indirectly compared overall survival (OS) with everolimus vs. 1) placebo and 2) sunitinib. Methods: Individual patient data were used from the RADIANT-3 trial of everolimus 10 mg/day vs. placebo (cutoff: April 4, 2010); published summary data were used from the A6181111 trial of sunitinib 37.5 mg/day vs. placebo (cutoff: June 1, 2010). To adjust for cross-trial differences, RADIANT-3 patients were subjected to exclusion criteria used in A6181111 and then re-weighted to match A6181111 in terms of baseline demographics, performance status, time since diagnosis, disease sites, distant metastases and prior therapy. After matching, OS was compared between balanced trial populations for everolimus in RADIANT-3 vs. 1) the placebo arm in A6181111, which had access to sunitinib after early stopping, and 2) the sunitinib arm in A6181111. Progression-free survival (PFS) was also assessed, but was confounded by early stopping of A6181111. Results: Analyses included 394 patients from RADIANT-3 (after excluding 15 with worse performance status than allowed in A6181111 and 1 with missing baseline data) and all 171 patients in A6181111. Before matching, patients in RADIANT-3 had better performance status, more prior use of somatostatin analogues and less prior use of systemic chemotherapy. After matching, these and all other baseline characteristics were well-balanced between trials. Everolimus was associated with prolonged OS vs. placebo in A6181111 (hazard ratio [HR] for death = 0.61, 95% CI = 0.38-0.98, p=0.04). No statistically significant difference was observed with everolimus vs. sunitinib in OS (HR for death = 0.81, 95%CI=0.49-1.31) or in PFS (HR for progression = 0.84, 95% CI=0.46-1.53). Conclusions: After adjusting for cross-trial differences, treatment of advanced pNET with everolimus was associated with prolonged OS compared to treatment with placebo.