tbuckley/cabot-search huggingface dataset:
RELATIVE CHARACTERISTICS OF THE AORTIC AND PULMONARY SECOND SOUNDS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel Blockers vs Angiotensin-Converting Enzyme Inhibitors
Authors: W. Rifkin
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GONORRHEAL ARTHRITIS
Authors: B. A. THOMAS
Journal: JAMA (1927)

"An inflammatory articular affection dependent upon gonorrhea" seems to have been first described by Salle and Swediaur in 1781, and further elaborated by Brodie in 1818. Presumably, John Hunter recognized the disease to be of venereal origin as early as 1716, but because of his false judgment and assertions that gonorrhea, chancre and syphilis were one and the same, thereby retarding investigation as to the true nature of those diseases for more than a century, until Ricord propounded the truth, he cannot be accredited as the pioneer in this field. Fournier, relative to phalangeal joint involvement, referred to the disease as "radish fingers." I can recall no disease, other than arthritis, in which the etiology and pathology are more diverse; therefore the difficulty, frequently encountered, particularly in those cases developing a few months or years after the acute attack of gonorrhea, in establishing the gonococcic origin of the condition. The
Hey Buddy
Authors: Leonard Rappaport
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Breathing
Authors: M. Wyrebek
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE REFORMATION IN ENGLISH SPELLING.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quality of Life
Authors: Michael D. Decker
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In his recent editorial (236:387, 1976), Dr Vaisrub opines that "the attained 'quality of life' [following aortocoronary bypass surgery] is apt to be void of social usefulness," based on the failure of patients studied, particularly those more than 55 years of age, to return to employment following this surgery, despite signal alleviation of incapacitating symptoms. Dr Vaisrub comments that "only self-confidence and proper motivation can fill this void." Dr Vaisrub very well may be right, but two things leave me uncomfortable with his position: first, there is apparently no information to indicate whether the failure to return to work is actually the result of a lack of self-confidence or whether it is a well-thought-out decision to spend the remaining years pursuing other interests and goals (a not unlikely choice in a man who feels snatched back from death's door, is more than 55 years of age, and
Comparative outcomes of laparoscopic and open major liver resection using benchmark article method and propensity score matching method
Authors: Hanisah Guro, Jai Young Cho, Ho Seong Han, Yoon Yoo Seok, Youngrok Choi, Boram Lee, Sook-Hyang Jeong, Jin-Wook Kim, Eun Sun Jang, Gwang Hyeon Choi
Journal: Journal of Hepatology (2020)
Long-term outcomes of persistently positive hepatitis B surface antigen after liver transplantation for chronic hepatitis B
Authors: Yan Yue James Fung, Albert CY Chan, Tiffany Wong, Wing-chiu Dai, Sui-ling Sin, Lung Yi Mak, Wai-Kay Seto, Man-Fung Yuen, Chung Mau Lo
Journal: Journal of Hepatology (2020)
Erratum for the Research Article: “Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation” by R. D. Kirkton, M. Santiago-Maysonet, J. H. Lawson, W. E. Tente, S. L. M. Dahl, L. E. Niklason, H. L. Prichard
Journal: Science Translational Medicine (2019)
Military’s Search for Meningitis Cases Linked With Contaminated Steroids
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chicago.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chikungunya
Authors: William Rodriguez-Cintron
Journal: Annals of Internal Medicine (2015)

Letters7 April 2015ChikungunyaWilliam Rodriguez-Cintron, MDWilliam Rodriguez-Cintron, MDFrom Veterans Affairs Caribbean Healthcare System, San Juan, Puerto Rico.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5076 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hamer and Chen's article (1) failed to mention and address the incidence of chikungunya virus in Puerto Rico, although the Centers for Diseases Control and Prevention eloquently did so in the Morbidity and Mortality Weekly Report (2). The first locally acquired, laboratory-confirmed case of chikungunya virus was detected in Puerto Rico in early May 2014, and 10 201 suspected cases (282 per 100 000 residents) had been reported by 12 August 2014. Certainly, there have been and will be implications locally in terms of public health. However, because of the known shunt between Puerto Rico and the mainland United ...References1. Hamer DH, Chen LH. Chikungunya: establishing a new home in the Western hemisphere. Ann Intern Med. 2014;161:827-8. [PMID: 25244354] doi:10.7326/M14-1958 LinkGoogle Scholar2. Sharp TM, Roth NM, Torres J, Ryff KR, Pérez Rodríguez NM, Mercado C, et al; Centers for Disease Control and Prevention (CDC). Chikungunya cases identified through passive surveillance and household investigations—Puerto Rico, May 5-August 12, 2014. MMWR Morb Mortal Wkly Rep. 2014;63:1121-8. [PMID: 25474032] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Veterans Affairs Caribbean Healthcare System, San Juan, Puerto Rico.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L15-0052. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChikungunya: Establishing a New Home in the Western Hemisphere Davidson H. Hamer and Lin H. Chen Chikungunya: Establishing a New Home in the Western Hemisphere Davidson H. Hamer and Lin H. Chen Chikungunya Tariq Al-Araimi and Shikha Mittoo Chikungunya Davidson H. Hamer and Lin H. Chen Chikungunya Davidson H. Hamer and Lin H. Chen Chikungunya Tariq Al-Araimi and Shikha Mittoo Metrics 7 April 2015Volume 162, Issue 7Page: 531KeywordsConflicts of interestDisclosureMorbidityPrevention, policy, and public health ePublished: 7 April 2015 Issue Published: 7 April 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Today's drugs. Triacetoxyanthracene.
Journal: BMJ (1967)

With the help of expert contributors we publish below notes on a selection of drugs in current use. TriacetoxyanthraceneThis topical preparation is marketed under the name of Exolan by Dermal Laboratories Limited. Chemistry and PharmacologyFractionation of crude tars showed that the most effective substances in the treatment of psoriasis were high-boiling poly- cyclic hydroxy compounds.This group of compounds includes chrysarobin and dithranol-both of considerable value in the treatment of psoriasis.Further study of dithranol showed that it exists as the keto form 1,8-dihydroxy-9-anthrone (Fig. 1).Dithranol may thus cause burning because of the reducing properties of the methylenic group at 10 position and staining because, if one of the hydroxyl groups is attached to skin, sub- sequent oxidation of the methylenic group leads to the for- mation of a quinone dye.
Norway’s new principles for primary prevention of cardiovascular disease: age differentiated risk thresholds
Journal: BMJ (2011)

Norway's new principles for primary prevention of cardiovascular disease: age differentiated risk thresholdsA mishap during editing caused the deletion of the first digit in each item of a bulleted list, leading to an overenthusiastic interpretation of Norway's recommendations for preventive drug treatment in this article by Ole Frithjof Norheim and colleagues (BMJ 2011;343:d3626, doi:10
First International Congress on Oral Cancer and Jaw Tumors
Journal: JNCI Journal of the National Cancer Institute (1987)

First International Congress on Oral Cancer and Jaw Tumors Get access JNCI: Journal of the National Cancer Institute, Volume 79, Issue 2, August 1987, Page 401, https://doi.org/10.1093/jnci/79.2.401-c Published: 01 August 1987
Patient Outcome and Valve Performance Following a Second Aortic Valve Homograft Replacement
Authors: K. Hasnat, E. J. Birks, J. Liddicoat, J. K. F. Hon, S. Edwards, S. Glennon, M. H. Yacoub
Journal: Circulation (1999)

Background —Homograft valves offer many advantages; however, there is concern about their use in second aortic valve replacement because of the complexity of the procedure and the possibility of accelerated degeneration. Methods and Results —One hundred and forty-four patients underwent a second aortic homograft replacement between 1973 and 1997 (mean follow-up 6.5±5 years, range 1 to 20 years). Eighty-three were male, and 61 were female, aged 17 to 77 years, mean 49.0 years. All patients had undergone previous aortic valve replacement with a homograft. The indication for reoperation was aortic regurgitation in 75 patients (52.1%), aortic stenosis in 28 (19.4%), and mixed aortic valve disease in 41 (28.5%). Root replacement was performed in 54 patients (38%) and subcoronary in 90 (62.5%). Early mortality was 3.4%. The actuarial survival rate was 93% and 82% at 5 and 10 years, respectively. Freedom from tissue degeneration was 96% and 80% at 5 and 10 years, respectively, and freedom from reoperation was 97% and 82% at 5 and 10 years, respectively. Conclusions —This study shows that a second aortic valve homograft replacement results in good early and long-term survival. Accelerated degeneration does not occur. Left ventricular performance is improved, and earlier surgery could further improve outcome, indicating that an aortic homograft is a safe, durable option for patients requiring a second aortic valve replacement.
Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids
Authors: Lisette I.Z. Kunz, Nick H. ten Hacken, Thérèse S. Lapperre, Wim Timens, Huib A.M. Kerstjens, Annemarie van Schadewijk, Judith M. Vonk, Jacob K. Sont, Jiska B. Snoeck-Stroband, Dirkje S. Postma, Peter J. Sterk, Pieter S. Hiemstra
Journal: European Respiratory Journal (2017)

We thank Dr Sohal and his colleagues for their correspondence regarding our recently published article in the European Respiratory Journal ( ERJ ) about airway inflammation in chronic obstructive pulmonary disease (COPD) after withdrawal of inhaled corticosteroids (ICS) [1]. We agree that COPD includes much more than airflow obstruction and airway inflammation alone and we would like to briefly respond to the issues raised in the correspondence. Detailed analysis of the effects of ICS on parameters beyond inflammation and lung function in COPD are needed <http://ow.ly/mPN530c035q> The GLUCOLD study group consists of the following participants. H.F. Kauffman and D. de Reus (Dept of Allergology); H.M. Boezen, D.F. Jansen and J.M. Vonk (Dept of Epidemiology); M.D.W. Barentsen, W. Timens and M. Zeinstra-Smit (Dept of Pathology); A.J. Luteijn, T. van der Molen and G. ter Veen (Dept of General Practice); M.M.E. Gosman, N.H.T. ten Hacken, H.A.M. Kerstjens, M.S. van Maaren, D.S. Postma, C.A. Veltman, A. Verbokkem, I. Verhage and K. Klooster (Dept of Pulmonology; all University of Groningen and University Medical Center Groningen, Groningen, the Netherlands). H.A. Thiadens (Dept of General Practice); J.B. Snoeck-Stroband and J.K. Sont (Dept of Medical Decision Making); J. Gast-Strookman, P.S. Hiemstra, K. Janssen, K.F. Rabe, A. van Schadewijk, J.A. Schrumpf, J. Smit-Bakker, J. Stolk, A.C.J.A. Tiré, H. van der Veen, M.M.E. Wijffels and L.N.A. Willems (Dept of Pulmonology; all Leiden University Medical Center, Leiden, the Netherlands). P.J. Sterk (Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands). T.S. Lapperre (Dept of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore, Singapore). T. Mauad (University of São Paulo, São Paulo, Brazil).
Correction to: Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer
Authors: Haihai Liang, Xiaoguang Zhao, Chengyu Wang, Jian Sun, Yingzhun Chen, Guoyuan Wang, Lei Fang, Rui Yang, Mengxue Yu, Yunyan Gu, Hongli Shan
Journal: Molecular Cancer (2020)

An amendment to this paper has been published and can be accessed via the original article.
A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients
Authors: J. M. McKenney
Journal: JAMA (1994)

<h3>Objective.</h3> —To compare escalating doses of immediate-release (IR) and sustained-release (SR) niacin for effectiveness in reducing levels of low-density lipoprotein cholesterol and triglycerides and increasing levels of high-density lipoprotein cholesterol, and for the occurrence of adverse reactions, especially hepatotoxicity. <h3>Design.</h3> —Randomized, double-blind, parallel comparison of IR and SR niacin administered sequentially at 500, 1000, 1500, 2000, and 3000 mg/d, each for 6 weeks. <h3>Setting.</h3> —Cholesterol research center. <h3>Patients.</h3> —Forty-six adults, 23 in each group, with low-density lipoprotein cholesterol levels greater than 4.14 mmol/L (160 mg/dL) after 1 month of a step 1 National Cholesterol Education Program diet. <h3>Outcome Measures.</h3> —Fourteen-hour fasting lipid and lipoprotein cholesterol levels, results of clinical laboratory tests, a symptom questionnaire, and withdrawal rates. <h3>Results.</h3> —The SR niacin lowered low-density lipoprotein cholesterol levels significantly more than IR niacin did at the dosage of 1500 mg/d and above, while IR niacin increased high-density lipoprotein cholesterol levels significantly more than SR niacin did at all dosage levels. The reduction in triglyceride levels was similar with IR and SR niacin. Nine (39%) of the 23 patients assigned to the IR dosage form withdrew before completing the 3000-mg daily dose; the most common reasons for withdrawal were vasodilatory symptoms, fatigue, and acanthosis nigricans. Eighteen (78%) of the 23 patients assigned to the SR dosage form withdrew before completing the 3000-mg daily dose; the most common reasons for withdrawal were gastrointestinal tract symptoms, fatigue, and increases in levels of liver aminotransferases, often with symptoms of hepatic dysfunction. None of the patients taking IR niacin developed hepatoxic effects, while 12 (52%) of the 23 patients taking SR niacin did. <h3>Conclusion.</h3> —The SR form of niacin is hepatotoxic and should be restricted from use. The IR niacin is preferred for the management of hypercholesterolemia but can also cause significant adverse effects and should be given only to patients who can be carefully monitored by experienced health professionals. (<i>JAMA</i>. 1994;271:672-677)
The Gulstonian Lectures on Anaemia
Authors: S. Coupland
Journal: BMJ (1881)

i.diootiali.1ernicious Ancmia: Illustr(4tive Cases-Analysis of, the D#'re;-cn.'Fornms of Disease-Tze term Idiopathic" not applic-a1le considlerable p,o/ortion-Preponderance in the Swiss Caintons (especially Zicirih) largely depende7t/ on Mode of Life---It;fluence of rcp Mv.cd Prezancies, Gastro-intestinal Disease, IZsmorrhage, MAa- lariz.and Nervous Disorders in deterinining a "Pernicious"Ana-mia -Pa-thogenyt: Is it to increasee Blood-Destruction orwant afBlood/-Formnation ?-Changes descr-ibed in Blood antd in Bone-marrow (PZe'ojer, Cohnheci;n, Osle;-)-Its -elationis to Leukhamia, to "Psetdo- leze!' .t-cfz'a",lo C1.,.orosis.I ,IL now proceed you the leading features of cases of idiopathic anaemia which have occurred in the Middlesex Hospital during past years.They are not numerous, and they do not coiimprise all forms which this condition occurs, but they will serve my subject.