tbuckley/cabot-search huggingface dataset:
ON THE LIFE-HISTORY OF ASCARIS LUMBRICOIDES
Authors: F. H. Stewart
Journal: BMJ (1916)

CONCLUSION.Recapitulating in brief, it may be said that, whatever particular theory of osteogenesis may be the true one, the following points have proved valuable in practice:Tlhe area of the graft must be kept scrupulously aseptic, and free from unnecessary blood clot.Adequate blood supply is necessary to the growth of the graft.T'lhe graft nmust be placed in close apposition to raw surfaces of tlle bone witlh wlhiclh it is to unite.The wlhole region must be kept fixed for a long period for undisturbed organiization to take place.Tlle bone graft slhould be autogenous, and it is better that it slhould include both periosteum and medulla wllerever this is possible, for both these aspects of tlle bonie afford facilities for the growtlh of new blood vessels.Surgeons should have patience, for union is often de- layed, and lhasty conclusions that union is not going to take place, and consequent relaxation of strict fixation of the part, mnay convert a case of delayed union into one of non-union.After aniy of thlese procedures it is essential to fix the linmb absolutely to let new vessels grow undisturbed by
THE SUGGESTED CALIFORNIA QUARANTINE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A3 adenosine receptors
Authors: L FABRITZ
Journal: Cardiovascular Research (2004)

Objective: An increased expression of adenosine receptors is a promising target for gene therapy aimed at protecting the myocardium against ischemic damage, but may alter cardiac electrophysiology. We therefore studied the effects of heart-directed overexpression of A3 adenosine receptors (A3ARs) at different gene doses on sinus and atrio-ventricular (AV) nodal function in mice. Methods and results: Mice with heart-specific overexpression of A3AR at high (A3high) or low (A3low) levels and their wild-type littermates were studied. Telemetric electrocardiogram (ECG) recordings in adult freely moving A3high mice showed profound sinus bradycardia resulting in either ventricular escape rhythms or an incessant bradycardia–tachycardia syndrome (minimal heart rate A3high 217±25*; WT 406±21 beats/min, all values as mean±S.E.M., n=7 per genotype, *p<0.05). Exercise attenuated bradycardia in A3high mice (maximal heart rate A3high 650±13*; WT 796±13 beats/min) and first-degree AV nodal block was present (PQ interval A3high 36±4*; WT 23±5 ms). Isolated hearts showed complete heart block (10/17 A3high* vs. 1/17 WT). Atrial bradycardia and AV block were already present 3 weeks after birth. Doppler echocardiography revealed atrial dysfunction and progressive atrial enlargement that was moderate at 3 and 8 weeks, and progressed at 12 and 21 weeks of age (all p<0.05 vs. WT). Atrial contractility and sarcoendoplasmic Ca2+ ATPase (SERCA) 2a protein expression were reduced in isolated left A3high atria at the age of 14 weeks. Fibrosis was present in left A3high atria at 14 weeks, but not at 5 weeks of age. A3low mice had first-degree AV block without arrhythmias or structural changes. Conclusions: Heart-directed overexpression of A3AR resulted in gene dose-dependent AV block and pronounced sinus nodal dysfunction in vivo. Profound bradycardia heralded atrial and ventricular dilatation, dysfunction, and fibrosis. In contrast to A1 adenosine receptors (A1AR), the effects of A3AR overexpression were attenuated during exercise. This may have implications for the physiology of sinus nodal regulation and for therapeutic attempts to increase the expression of adenosine receptors.
Working women don't have increased heart disease
Authors: J. P. Callan
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analgesics in the acute phase of myocardial infarction
Authors: E. L. Alderman
Journal: JAMA (1974)

THE pain of myocardial infarction may be severe and persistent, but generally disappears once effective analgesic therapy is given. The pain itself and the associated stresses of hospitalization, physician examination, and the fear of illness and potential death tend to provoke a prominent anxiety state. These factors promote hyperventilation and restlessness, and thus greater demands for oxygen, all of which impose greater stress on the damaged heart. Morphine sulfate has generally been the drug of choice for pain relief under these circumstances, but other agents such as meperidine hydrochloride and pentazocine have been suggested. In most respects, meperidine may be considered similar to morphine. Although it had been thought that meperidine is spasmolytic and is less prone to produce respiratory depression, nausea, and vomiting, this has not been borne out by controlled studies of equipotential doses. It is important in the selection of an analgesic agent that its respiratory and
EDUCATION OF THE NEGRO PHYSICIAN
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation–Induced Immune Suppression
Authors: Wei Wang, Nicole M. Chapman, Bo Zhang, Mingqi Li, Meiyun Fan, R. Nicholas Laribee, M. Raza Zaidi, Lawrence M. Pfeffer, Hongbo Chi, Zhao-Hui Wu
Journal: Cancer Research (2019)

In the original version of this article (1), the image used in Fig. 7E to represent immunostaining of PD-L1 in UVB+CTL+α-PD1 was inadvertently taken from UVB+CTL. The image has been replaced with the intended image for UVB+CTL+α-PD1. The error does not affect the conclusion and has been corrected in the latest online HTML and PDF versions of the article. The authors regret this error.
X-Ray Diagnosis And Treatment.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypermagnesemia-induced hypotension and hypoventilation
Authors: H. Zwerling
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Clinically significant hypermagnesemia occurs infrequently in patients with normal renal function.<sup>1</sup>A patient is presented who developed hypermagnesemia-induced hypotension and respiratory depression, which was precipitated by the administration of magnesium citrate to a patient with a small-bowel obstruction who had normal renal function. <h3>Report of a Case.</h3> —A 64-year-old woman was admitted with abdominal pain. She had a history of vitamin D deficiency that was well controlled on 1,25(OH)<sub>2</sub>[calcitriol] vitamin D and calcium carbonate (CaCO<sub>3</sub>). She discontinued these medicines 2 years prior to admission. On admission (<i>t</i>= -25 h), she was hypocalcemic, hypomagnesemic, hypokalemic, and had an elevated alkaline phosphatase level. Her serum creatinine level was normal. The patient was treated with calcium, potassium, parenteral magnesium sulfate (MgSO<sub>4</sub>) (Mg<sup>++</sup>8.1 mmol by continuous infusion from<i>t</i>= -9.7 h through<i>t</i>= -0.3 h) and oral magnesium citrate (Mg<sup>++</sup>125 mmol) at<i>t</i>= -23.7
Section 46.—Hyperlipoproteinemia
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening Mammography and Risk of Breast Cancer
Authors: Ursula Werneke
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The study by Dr Kerlikowske and colleagues<sup>1</sup>on the effect of age, breast density, and family history on the sensitivity of first screening mammography is an important contribution to the debate on the age at which screening for breast cancer should start. The balanced discussion of their results highlighting the problems involved with screening women aged 40 to 49 years is particularly valuable. They draw attention to the questionable value of the early diagnosis of ductal carcinoma in situ (DCIS) when it may not progress to invasive disease and to the fact that the effectiveness for reducing mortality from breast cancer has yet to be proven in this age band. Unfortunately, the main findings of this study have been interpreted by a popular medical newspaper,<i>Arzte Zeitung</i>, as further evidence for recommending mammography for women aged 40 to 49 years on an annual basis<sup>2</sup>without
Danish out of hours service is working well
Journal: BMJ (1998)

Some small for gestational age fetuses have higher risk of late fetal death than othersIn small for gestational age fetuses, without congenital malformations, constitutionally small fetuses-for example twins or the fetuses of short mothers-have been assumed to at lower risk of late fetal death than fetuses affected by conditions such as pre-eclampsia or cigarette consumption.Cnattingius et al (p 1483) tested that assumption in over 1 million births in the Swedish birth register.Overall, late fetal mortality was increased in women who were over 35, nulliparous, smoked, or were <155 cm tall and greatly increased in those with pre-eclampsia, essential hypertension, and twin pregnancies.But in very small for gestational age fetuses death rates were lower in women aged under 35, <155 cm tall, with twins, or with severe eclampsia or hypertension.
Clinical Bio-Chemistry.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Overmanagement of the alcoholic patient
Authors: M. J. Finer
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Much again is being made of the poor nutritional status of American children, especially the disadvantaged. However, these "findings" have not provided answers except the usual generalities and clichés. Surprisingly, studies of growth and development continue to show that children keep growing taller, heavier, bigger, and brighter. Being the physician to the poor during the last half of the 1930s within my health department district in Cincinnati, I was impressed by the relationship of the state of the home environment and child nutrition. Variances in attitudes, aspirations, expectations, simple knowledge, and know-how were marked among mothers of both white and nonwhite poor. During the same period, differences observed within the middle-class populations of public and parochial schools and their parents were more subtle, but observable. The poor who moved into the first garden-apartment-type public housing were offered classes in sewing, purchasing, cooking, housekeeping, etc. Then, it was
Cost of drugs in Australia's pharmaceutical benefit scheme
Authors: R. A. Derby
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The article by Dr Peabody and colleagues<sup>1</sup>on the Australian health care delivery system and its relevance to the United States offered much interesting information, but their statement that pharmaceutical costs per capita in Australia are 20% greater than in the United States may be misleading to those trying to gain an understanding of Australia's Pharmaceutical Benefit Scheme (PBS). If accurate, this figure demonstrates more about lack of access to medicines in the United States than expense of drugs with the PBS. It has been suggested that prescription drug use rates are lower in the United States than Australia. This is primarily due to 2 factors: first, lack of prescription drug insurance coverage in the United States and, second, the higher prices that manufacturers charge in the United States compared with the rest of the industrialized world. Manufacturers' prices for the same prescription drug are generally
Quadrilateral Peripheral Vascular Disease in the Young Adult
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe dyspnea in a women with known tuberculosis
Authors: L. Calenoff
Journal: JAMA (1977)

<h3>History</h3> A 35-year-old woman presented with severe dyspnea, left shoulder pain, and a dry cough. There were dullness and decreased breath sounds over the left side of the chest posteriorly. Her illness had started one year ago with productive cough, a left lower lobe infiltrate, and positive sputum cultures for<i>Mycobacterium tuberculosis</i>. She had been receiving antituberculosis treatment. Figures 1 and 2 are recent posteroanterior and lateral teleroentgenograms. <h3>Diagnosis</h3> Atelectasis of the left lung due to complete occlusion of the left main bronchus, resulting from bronchial tuberculosis. <h3>Comment</h3> The chest roentgenograms (Fig 1 and 2) show a striking shift of the mediastinum to the left, narrowing of the left intercostal spaces, and elevation of the left hemidiaphragm. The right lung has herniated to the left, passing in front of the mediastinum. The bronchogram (Fig 3) demonstrates a totally occluded left main bronchus (arrows). The occluded bronchus is also visible on
Survival in Women After Diagnosis of Lung Cancer
Authors: Peter B. Bach
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
House staff and the National Labor Relations Act
Authors: R. M. Stanifer
Journal: JAMA (1979)

THE CONGRESS of the United States has failed to pass legislation that would accord physicians-intraining (by convention called residents, house officers, or house staff) a status comparable to that of other hospital personnel. Such a designation of residents as employees is controversial since it is contrary to a 1976 ruling by the National Labor Relations Board (NLRB), which stated that residents are to be considered students for the purpose of the National Labor Relations Act. During the proceedings of the 95th Congress, Representative Frank Thompson (Democrat, NJ) introduced and sponsored House Bill 2222, which would have amended the National Labor Relations Act to include residents. Because of a busy congressional schedule, House Bill 2222 did not receive final action. I believe it is extremely important to inform physicians about the importance of this legislative issue. Today, more than 80% of the financial support for graduate medical education is derived from
Uric acid excretion in sickle cell anemia
Authors: B. R. Walker
Journal: JAMA (1971)

Hyperuricemia of unknown etiology has been associated occasionally with sickle cell anemia (SS). Asymptomatic SS patients were compared to normal volunteers, with the former showing a significant increase in the ratio of total uric acid to creatinine excretion suggesting increased purine synthesis. There was no difference between the two groups in the ratio of uric acid to creatinine clearance (C<sub>Ur</sub>/C<sub>Cr</sub>), nor were there abnormalities in peripheral lactate and pyruvate levels in the SS group. When the SS patients were separated into those with hyperuricemia and those without, there was a significant decrease in C<sub>Ur</sub>and C<sub>Ur</sub>/C<sub>Cr</sub>in the hyperuricemics. These findings suggest that hyperuricemia in SS patients occurs when defective renal function is superimposed on the excessive purine synthesis. It is not known whether the hyperuricemia or uricosuria plays any role in sickle cell nephropathy.