tbuckley/cabot-search huggingface dataset:
A RETROSPECT OF THE CHICAGO SESSION
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Experimental Approach to the Evaluation of the Biopersistence of Respirable Synthetic Fibers and Minerals
Authors: David M. Bernstein, Richard Mast, Robert Anderson, Thomas W. Hesterberg, Rod Musselman, Ole Kamstrup, John Hadley
Journal: Environmental Health Perspectives (1994)

The biopersistence of fibers and minerals in the respiratory tract is an important parameter in the toxicity of those materials.The biopersistence of respirable synthetic fibers and minerals in man can be most closely evaluated in an animal model.While acellular and in vitro systems are important for initial evaluation of solubility and durability, they cannot simulate the dynamics of inhalation deposition and clearance and the subsequent sys- temic reaction to fibers and minerals that occurs in the animal.To evaluate the biopersistence of synthetic fibers, male rats were exposed to a well defined rat respirable aerosol of man-made vitreous fibers (MMVF), 6 hr/day for 5 days.Following exposure, subgroups were sacrificed at intervals ranging from 1 hr to 52 weeks.Following sacrifice, the lungs were removed, weighed, and immediately frozen at 20°C for subsequent digestion by low temperature plasma ashing.The number, size distribution, and chemical composition of the fibers in the aerosol and lung were determined.With this animal model the role of biopersistence in altering the geometry and clearance of fibers can be systematically evaluated.The model also can be applied for the evaluation of the biopersistence of nonfibrous minerals.-
COMMITTEE OF THE NATIONAL ACADEMY OF SCIENCES ON THE INVESTIGATION OF CORTISONE
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 555: A novel human TNFR2 antibody (MM-401) modulates T cell responses in anti-cancer immunity
Authors: James F. Sampson, Vinodh B. Kurella, Violette Paragas, Sandeep Kumar, James E. Lulo, James A. Qiu, Maja Razlog, Ross B. Fulton, Adam J. Camblin, Jennifer M. Richards, Christina S. Wong, Alexander Koshkaryev, James J. Suchy, Stephanie Grabow, Marco Muda, Andreas Raue, Daryl C. Drummond, Eric M. Tam
Journal: Cancer Research (2019)

Abstract TNFR2 is an emerging therapeutic target in immuno-oncology. We have previously shown that an agonistic mouse TNFR2 antibody was able to activate CD8+ T cells in vitro and has anti-tumor activity in multiple syngeneic mouse tumor models. This activity required CD8+ T cell and NK cell response and involves Fc γ receptor engagement. Based on this compelling evidence, we have developed MM-401, a human antibody targeting the TNFR2 receptor. MM-401 was humanized from a mouse hybridoma antibody by CDR grafting and includes additional mutations for improved affinity and biophysical properties. Consequently, MM-401 binds with low nanomolar affinity to a region in human TNFR2 that corresponds to the mouse TNFR2 epitope of our mouse surrogate antibody. Although the antibody competes with TNF α in binding the receptor, MM-401 has agonistic activity and induces TNFR2 signaling as observed using a NFκB reporter cell assay. Upon incubation of MM-401 with CD4+ and CD8+ T cells from healthy human blood, we observed upregulation of activation markers and cytokine production comparable to utomilumab (anti-4-1BB), MEDI6469 (anti-OX40), and TRX518 (anti-GITR). We also observed that MM-401 promotes antibody-dependent cellular cytotoxicity (ADCC) in an NK cell-mediated in vitro assay and a reduction in the number regulatory T (Treg) cells in ovarian cancer ascites samples. These data suggest that MM-401 could also promote anti-tumor immunity by mediating ADCC, as well as by direct co-stimulation of T cell responses. Currently, we are evaluating MM-401 in patient derived xenograft (PDX) models in humanized mice generated using NSG-SGM3 mice with cord blood CD34+ hematopoietic stem cells. These results justify the continued development of MM-401 as a modulator of anti-tumor immunity for the treatment of cancer. Citation Format: James F. Sampson, Vinodh B. Kurella, Violette Paragas, Sandeep Kumar, James E. Lulo, James A. Qiu, Maja Razlog, Ross B. Fulton, Adam J. Camblin, Jennifer M. Richards, Christina S. Wong, Alexander Koshkaryev, James J. Suchy, Stephanie Grabow, Marco Muda, Andreas Raue, Daryl C. Drummond, Eric M. Tam. A novel human TNFR2 antibody (MM-401) modulates T cell responses in anti-cancer immunity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 555.
Abstract 18913: Spontaneous Coronary Artery Dissection in Women and Association With Hormonal Stressors
Authors: Lim Eng, Andrew Starovoytov, Milad Heydari, Jacqueline Saw
Journal: Circulation (2015)

Background: Spontaneous coronary artery dissection (SCAD) is an infrequent but important cause of myocardial infarction (MI) in women. Chronic exposure to hormonal therapy, fluctuation in hormonal levels, and a history of multiple pregnancies had been postulated to predispose to SCAD. However, these were not well described in the literature. Methods: Women with SCAD who have consented and are prospectively followed in our Vancouver General Hospital SCAD registries are included in this study. Their background hormonal exposure, pregnancy, and gynaecological histories were extracted from questionnaires, clinical histories, and medical records. These were correlated to in-hospital and long-term outcomes. Results: We included 187 women with SCAD, with mean age 52.6 ± 8.7 years. The majority were Caucasian (83.4%) and 74.0% had fibromuscular dysplasia. All patients presented with MI. Mean number of pregnancy in this cohort was 2.5, with 45 (24.1%) and 25 (13.4%) having ≥4 and ≥5 pregnancies, respectively. Mean number of live births (parity) was 1.8, with 52 (27.8%) having ≥3 births, and 16 (8.6%) having ≥4 births. There were 3 post-partum SCAD (&lt;1 year) and they were still breastfeeding. In terms of hormonal therapy, 28 (15.0%) were actively on hormonal therapy; 5 (2.7%) had prior fertility treatment, 51 (27.3%) had hormone replacement therapy (HRT), 76 (40.6%) had oral contraception, and 36 (19.3%) had gynaecological procedures. There were 107 (57.2%) post-menopausal women, and 23 (12.3%) were peri-menopausal at presentation. There was no death during acute SCAD admission, but 3 died at follow-up (mean 4.1 ± 3.9yrs), and 36 (19.3%) had recurrent SCAD. Patients actively on hormones had higher rate of recurrent SCAD (32.1% vs. 15.8%, p=0.039). There was a higher recurrent MI rate in premenopausal women during index admission (8.9% vs. 1.9%, p=0.037). There was no significant difference in in-hospital and follow-up events in women with past hormonal therapy, post-partum women, or those with parity ≥4 or gravida ≥5. Conclusion: Significant proportion of women with SCAD had exposure to hormonal therapy or had multiple pregnancies/births. Patients actively on hormonal therapy appeared to have higher recurrent SCAD events at follow-up.
There is more (or less) to tobacco than smoking
Authors: S. Vaisrub
Journal: JAMA (1979)

Old-timers, who still remember nostalgically the polished brass cuspidors in Pullman car smoking rooms, need not be told that there is more to tobacco than smoking. But only the occasional sight of the odd ballplayer perfunctorily emitting streams of brownish saliva as a macho ritual reminds the young that tobacco can be chewed as well as smoked. To the community of Maharashtra, India, however, chewing tobacco is not a distant nostalgic memory but a disturbing reality. In this tobacco-growing town, the habit is prevalent even among pregnant women, with potential harm to the fetus. To determine the extent of this harm, Krishna<sup>1</sup>conducted a study on 1,393 hospitalized pregnant women, each delivered of a single infant. Two hundred twenty (15.8%) of these women chewed tobacco. The nicotine content of the 50 to 100 g of tobacco chewed daily by each was estimated to be 4.24%. Mothers who chewed tobacco
PERNICIOUS ANAEMIA
Authors: G. Ward
Journal: BMJ (1923)

Perception of depth is based on a variety of cues, with binocular disparity and motion parallax generally providing more precise depth information than pictorial cues. Much is known about how neurons in visual cortex represent depth from binocular disparity or motion parallax, but little is known about the joint neural representation of these depth cues. We recently described neurons in the middle temporal (MT) area that signal depth sign (near vs far) from motion parallax; here, we examine whether and how these neurons also signal depth from binocular disparity. We find that most MT neurons in rhesus monkeys (<i>Macaca Mulatta</i>) are selective for depth sign based on both disparity and motion parallax cues. However, the depth-sign preferences (near or far) are not always aligned: 56% of MT neurons have matched depth-sign preferences (“congruent” cells) whereas the remaining 44% of neurons prefer near depth from motion parallax and far depth from disparity, or vice versa (“opposite” cells). For congruent cells, depth-sign selectivity increases when disparity cues are added to motion parallax, but this enhancement does not occur for opposite cells. This suggests that congruent cells might contribute to perceptual integration of depth cues. We also found that neurons are clustered in MT according to their depth tuning based on motion parallax, similar to the known clustering of MT neurons for binocular disparity. Together, these findings suggest that area MT is involved in constructing a representation of 3D scene structure that takes advantage of multiple depth cues available to mobile observers.
Evidences of a alloimmunization for HLA antigens of potencial receptors for liver transplant M.H. Kraemer, A. Sakamoto, C. Berenhauser-Leite, I.F.S.F. Boin, L.S. Leonardi. Unidade de Imunogenética de Transplante, Division of Gastroenterological Surgery, State University of Campinas. Campinas-SP, Brazil
Journal: Hepatology (1994)
The Effects of Internal Radiation Exposure on Cancer Mortality in Nuclear Workers at Rocketdyne/Atomics International
Authors: Beate Ritz, Hal Morgenstern, Douglas Crawford-Brown, Bambi Young
Journal: Environmental Health Perspectives (2000)

We examined the effects of chronic exposure to radionuclides, primarily uranium and mixed-fission products, on cancer mortality in a retrospective cohort study of workers enrolled in the radiation-monitoring program of a nuclear research and development facility. Between 1950 and 1994, 2,297 workers were monitored for internal radiation exposures, and 441 workers died, 134 (30.4%) of them from cancer as the underlying cause. We calculated internal lung-dose estimates based on urinalysis and whole-body and lung counts reported for individual workers. We examined cancer mortality of workers exposed at different cumulative lung-dose levels using complete risk-set analysis for cohort data, adjusting for age, pay type, time since first radiation monitored, and external radiation. In addition, we examined the potential for confounding due to chemical exposures and smoking, explored whether external radiation exposure modifies the effects of internal exposure, and estimated effects after excluding exposures likely to have been unrelated to disease onset. Dose-response relations were observed for death from hemato- and lymphopoietic cancers and from upper aerodigestive tract cancers, adjusting for age, time since first monitored, pay type, and external (gamma) radiation dose. No association was found for other cancers, including cancers of the lung. Despite the small number of exposed deaths from specific cancer types and possible bias due to measurement error and confounding, the positive findings and strong dose-response gradients observed suggest carcinogenic effects of internal radiation to the upper aerodigestive tract and the blood and lymph system in this occupational cohort. However, causal inferences require replication of our results in other populations or confirmation with an extended follow-up of this cohort.
Heberden Society
Journal: Annals of the Rheumatic Diseases (1957)

21 figs, 4 diagrams, English summary.Vydavatelstvo Slovenskej Acad& mie Vied, Bratislava.(19.50 kcs).This monograph, with an excellent summary in English, is based on a study of 102 cases, 54 males and 48 females, belonging to fifteen families.There is a discussion on theories of aetiology and the familial tendency, and on the difficulty in breaking down the benzene nucleus of Tyrosine and hence the formation of homogentistic acid.This is followed by an account of the clinical characteristics of the disease, ocular pigmenta- tion being the first sign, which was most commonly found between the third and fifth decades.The earliest joint symptoms in this series occurred at the age of 27 and the average age was 34.Changes in the spine with loss of the physiological curves, secondary degenerative changes, and actual loss of height, due to vertebral changes, were characteristic.The arthropathy was extensive and rapidly progressive in many cases, but was not, as a rule, accompanied by great pain.There was associated narrowing of the intervertebral disks and a doubling of the outline.The thoraco-lumbar junction was the most common site of first appearance.Pseudocystic osteoid formations occurred typically at certain tendinous insertions, especially at those of the long head of the biceps, supra-spinatus, and rectus femoris muscles.Massive pigment deposits appeared in the ligaments and peri-articular tissues.Other non-articular changes are discussed.No treatment was found to be of great value, other than the normal precautions employed in degenerative joint disease, although it was noted that two patients had a marked remission of symptoms and reduction in excretion of homogentisic acid while under treatment with methyl thiouracil.
RESTAURANT TREATMENT IN INDUSTRIAL ACCIDENT CASES
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fracture of Cervical Spine in Patients with Ankylosing Spondylitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Centers for Disease Control. National Adult Immunization Awareness Week
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomized study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel versus docetaxel alone for second-line therapy of lung adenocarcinoma (GALAXY-1).
Authors: Suresh S. Ramalingam, Glenwood D. Goss, Zoran Gojko Andric, Igor Bondarenko, Bojan Zaric, Timur Ceric, Elena Vladimir Poddubskaya, Tudor-Eliade Ciuleanu, James F. Spicer, Enriqueta Felip, Vera Hirsh, Christian Manegold, Rafael Rosell, Fadlo Raja Khuri, Vojislav M. Vukovic, Florentina Teofilovici, Iman El-Hariry, Wei Guo, Safi R. Bahcall, Dean Fennell
Journal: Journal of Clinical Oncology (2013)

CRA8007 Background: Heat shock protein 90 chaperone function is critical for the biological effects of several oncoproteins. Ganetespib (G) is a highly potent 2nd-generation Hsp90 inhibitor with a favorable safety profile and single-agent clinical activity. Methods: Based on synergistic preclinical interactions between docetaxel (D) and G, we conducted a randomized (1:1), international open-label study of D with or without G. Patients with advanced lung adenocarcinoma, one prior systemic therapy, and ECOG PS 0/1 were included. D was given at 75 mg/m 2 on day 1 of a three-week cycle. In the experimental arm, D was given on day 1 and G at 150 mg/m 2 on days 1 and 15. The co-primary endpoints were PFS in patients with elevated LDH (eLDH) levels, or tumors harboring KRAS mutations. Key secondary endpoints were OS and PFS in all adenocarcinoma patients. Target enrollment was 240 adenocarcinoma, 120 eLDH, and 80 mKRAS patients. Statistical tests are 1-sided. Results: Enrollment of 255 adenocarcinoma patients completed in November 2012; results are reported for this population. Patient characteristics were balanced (median age 60 years, males ~60%, PS 0 ~40% and never-smoker ~25%). For D+G vs. D the median number of cycles delivered was 5 vs. 4; the grade 3/4 adverse events were neutropenia 38% vs. 37%; fatigue 4% vs. 3%; anemia 7% vs. 6%; diarrhea 3% vs. 0; fever with neutropenia 8% vs. 2%. At the time of abstract submission OS HR was 0.69 (90% CI 0.48 to 0.99, p=0.093), the PFS HR was 0.70 (90% CI 0.53 to 0.94, p=0.012), and the ORR was 15% vs 11%, favoring D+G. For patients that were enrolled &gt;6 months after diagnosis of advanced NSCLC (N=175; 69%), a prespecified stratification factor, the OS HR was 0.41 (90% CI 0.25 to 0.67, p=0.0009), the PFS HR was 0.47 (90% CI 0.32 to 0.69, p=0.0005), and the ORR was 16% vs 12%. Updated results for both populations above, as well as for the eLDH and mKRAS subsets, will be presented. Conclusions: D+G demonstrated improvement in OS, PFS, and ORR over D alone for second-line therapy of lung adenocarcinoma. A phase III study in second-line advanced adenocarcinoma patients (&gt; 6 months from diagnosis) is ongoing (GALAXY-2). Clinical trial information: NCT01348126.