tbuckley/cabot-search huggingface dataset:
Prognostic significance of neutrophil to lymphocyte ratio (NLR) in patients with resectable oesophageal/gastroesophageal junction (O/GOJ) adenocarcinoma undergoing perioperative chemotherapy.
Authors: Zena Salih, George Papaxoinis, Alicia Conway, Ana Sofia Jardim Patrao, Kimberly Fletcher, Robert Noble, Vikki Owen-Holt, Wasat Mansoor
Journal: Journal of Clinical Oncology (2016)

e15571 Background: Currently, no validated preoperative prognostic markers exist for patients (pts) with resectable oesophageal/gastroesophageal (O/GOJ) junction adenocarcinoma (AC). There is evidence that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) predict outcomes in different types of malignancies. The aim of the current study was to explore the prognostic significance of NLR and PLR in pts with resectable O/GOJ AC undergoing perioperative chemotherapy. Methods: In this single-centre retrospective cohort study, neutrophil, lymphocyte and platelet blood count levels from the date of 1stcycle of neoadjuvant chemotherapy were collected from 368 pts with resectable Ο/GOJ AC. Pts started perioperative ECX based chemotherapy from Jul' 09 to Dec' 14. The prognostic significance of baseline blood count levels with tumour resectability was tested by Cox-regression analysis. All comparisons were two-sided with level of significance p < 0.05. Results: A total of 368 pts were included: 200 pts (54%) had O and 168 (46%) had GOJ primaries. Performance status (PS) ECOG was 0 in 127 (35%) and 1-2 in 241 pts (65%). Among them, 287 pts (78%) had curative surgery. After a median follow-up of 42 months (mo) (range, 0.5-73), 194 pts (53%) progressed or relapsed and 211 (57%) deceased. High NLR was associated with shorter OS (HR = 1.08, 95%CI = 1.01-1.15, p = 0.026). Pts with NLR > 3 had shorter median OS compared to those with NLR ≤ 3 (29 vs 23 mo, p = 0.032). Subgroup analysis showed that the effect of NLR on OS was restricted to pts with GOJ tumours (33 vs 17 mo, p = 0.001, for NLR ≤ 3 vs NLR > 3, respectively). Μultivariate analysis in the subgroup of GOJ patients showed that NLR could predict OS as continuous (HR = 1.16, 95%CI = 1.08-1.25, p < 0.001), as well as categorical variable ( ≤ 3.0 vs > 3.0, HR = 2.040, 95%CI = 1.36-3.06, p = 0.001). PS (ECOG) was also an independent prognostic factor (HR = 1.93, 95%CI = 1.26-2.94, p = 0.002). Conclusions: High NLR is highly prognostic in pts with resectable GOJ AC undergoing perioperative chemotherapy. NLR in combination with PS might be useful for the prognostic stratification of these pts.
L'auscultation dans le diagnostic de la tuberculose pleuropulmonaire. Par René Burnand.
Journal: JAMA (1931)

This careful work on physical diagnosis carries a preface by Professor Bezançon, who voices a protest, which seems to be as necessary in France as it is in America, against the tendency of many medical men to place a high value on roentgen diagnosis to the exclusion—or limitation—of careful stethoscopy. Burnand considers that the medical profession has forgotten the finer distinctions of physical sign description developed by our elders in the art. He admits that perhaps briefer and broader formulas have been gained but thinks that while these attain a greater simplicity they fail in large measure to mirror correctly the realities. It is necessary, therefore, to revive and reform our stethoscopy as well as to restate our conceptions. Nevertheless, Burnand would in no degree deprecate the use of the x-ray film. Laboratory methods are of inestimable value but should not be accorded full superiority in diagnosis. The author has
Resection of the Duodenum for Extensive Leiomyosarcoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction to: Lipid-Lowering Agents: Targets Beyond PCSK9
Journal: Circulation Research (2020)

A phase 3 program evaluating LDL-C reduction with inclisiran and cardiovascular outcomes in high-risk populations, including patients with heterozygous FH and ASCVD, is underway (www.clinicaltrials.gov:NCT02993406)." should read "A phase 3 program evaluating LDL-C reduction with bempedoic acid and cardiovascular outcomes in high-risk populations, including patients with heterozygous FH and ASCVD, is underway (www.clinicaltrials.
Differential Diagnosis of Jakob-Creutzfeldt Disease
Authors: Ross W. Paterson, Charles C. Torres-Chae, Amy L. Kuo, Tim Ando, Elizabeth A. Nguyen, Katherine Wong, Stephen J. DeArmond, Aissa Haman, Paul Garcia, David Y. Johnson, Bruce L. Miller, Michael D. Geschwind
Journal: JAMA Neurology (2012)

Objectives: To identify the misdiagnoses of patients with sporadic Jakob-Creutzfeldt disease (sCJD) during the course of their disease and determine which medical specialties saw patients with sCJD prior to the correct diagnosis being made and at what point in the disease course a correct diagnosis was made.Design: Retrospective medical record review.Setting: A specialty referral center of a tertiary academic medical center.Participants: One hundred sixty-three serial patients over a 5.5-year period who ultimately had pathologically proven sCJD.The study used the subset of 97 patients for whom we had adequate medical records.Main Outcome Measures: Other diagnoses considered in the differential diagnosis and types of medical specialties assessing patients with sCJD.Results: Ninety-seven subjects' records were used in the final analysis.The most common disease categories of misdiagnosis were neurodegenerative, autoimmune/ paraneoplastic, infectious, and toxic/metabolic disor-ders.The most common individual misdiagnoses were viral encephalitis, paraneoplastic disorder, depression, vertigo, Alzheimer disease, stroke, unspecified dementia, central nervous system vasculitis, peripheral neuropathy, and Hashimoto encephalopathy.The physicians who most commonly made these misdiagnoses were primary care physicians and neurologists; in the 18% of patients who were diagnosed correctly at their first assessment, the diagnosis was almost always by a neurologist.The mean time from onset to diagnosis was 7.9 months, an average of two-thirds of the way through their disease course.Conclusions: Diagnosis of sCJD is quite delayed.When evaluating patients with rapidly progressive dementia with suspected neurodegenerative, autoimmune, infectious, or toxic/metabolic etiology, sCJD should also be included in the differential diagnosis, and appropriate diagnostic tests, such as diffusion brain magnetic resonance imaging, should be considered.Primary care physicians and neurologists need improved training in sCJD diagnosis.
Fe-nitrilotriacetic acid-binding proteins associated with rat liver plasma membrane
Authors: D Barisani
Journal: Hepatology (1996)

The uptake of nontransferrin-bound iron by hepatocytes is known to occur and may contribute to the deposition of iron and resulting injury during hemochromatosis. To examine the proteins that may function in the transport of nontransferrin-bound iron, the properties of FeNTA- binding to rat liver basolateral plasma membranes were characterized. The binding of 55FeNTA to purified liver basolateral plasma membranes was measured using a simple centrifugation assay. The binding activity could be solubilized with 0.1% octylglucoside; apparent molecular weight Mapp approximately 210 kd for the binding complex was determined by gel filtration chromatography. Immobilized metal affinity chromatography was used to further purify binding protein(s) from rat liver plasma membranes and at least six polypeptides were identified by silver staining. If associated in a stoichiometric complex, the molecular mass of these proteins would predict a size of approximately 227 kd in fairly close agreement with the gel filtration experiments. The characterization of FeNTA-binding proteins associated with basolateral membranes is the first step towards understanding elements responsible for the uptake of nontransferrin-bound iron by the liver. (Hepatology 1996 Oct;24(4):934-8)
International Journal of Leprosy, Washington, DC
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: Clinical Nuclear Medicine (2000)

In the October 2000 issue of the journal (vol. 25, no. 10, pp. 779–784), an error appeared in the abstract of the article by Esko Vanninen, Tomi Laitinen, Kaarina Partanen, Harri Tulla, Arto Herno, and Heikki Kröger, “Late Correlative Imaging Findings of Previous Acute Infective Spondylitis.” The correct abstract is printed here: Purpose: To evaluate late correlative imaging findings in relation to clinical outcome in persons with previous acute infective spondylitis, the authors performed bone and leukocyte scintigraphy (planar and SPECT imaging) and magnetic resonance imaging of the spine in nine patients (two men, seven women; mean age, 66 years; age range, 57 to 84 years) 3.1 years (range, 0.9 to 6.2 years) after the acute disease. Methods: All images were evaluated visually. The relevant uptake on SPECT images was also quantitated using an adjacent normal vertebral body as the reference area. Results: Except for one patient, all other patients had increased uptake in the affected vertebra on bone scintigraphy. In leukocyte scintigraphy, clearly decreased uptake was noted quantitatively in six of the seven patients who underwent SPECT. On the magnetic resonance and computed tomographic scans, the typical findings were destruction of intervertebral disks and compression deformities of vertebral bodies, but there was high interindividual variance of other findings, such as osteophytes, spondylolisthesis, increased vertebral fat content, and postoperative changes. These data show that nearly all patients with previously acute infective spondylitis have gross abnormal anatomic and functional imaging findings years after the acute disease, despite good clinical outcome. Conclusions: The utility of bone and leukocyte scans in the diagnosis of reactivated spondylitis is limited, and incidentally observed abnormal imaging findings in asymptomatic patients with known previous spondylitis should be interpreted with caution.
Additions to Terrorism Preparedness Compendium
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: BMJ (1868)

June 6, i868. ducts, with their columnar epithelium unchanged, multiplied IOO di- ameters.The lower figure represents a part of the new growth shewing a mass of cells and nuclei of elongated form, constituting a cord-like body, like those seen under the skin, multiplied IOOO diameters; and a * April 22nd, r868.Since this was written and sent to
Highlights of Medical Licensure
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary-function response to radioisotope scanning of the lungs
Authors: W. M. Gold
Journal: JAMA (1966)

THE PULMONARY SCAN with radioactive particulate material has been proved to be an effective and easy method to demonstrate the pulmonary blood flow by radioisotope scanning technique.<sup>1</sup>The major clinical usefulness has been in the investigation of pulmonary infarcts, but its usefulness is being extended to include investigation of a number of pulmonary problems.<sup>2,3</sup> The most common material used for this scanning procedure has been macroaggregated human serum albumin labeled with radioactive iodine (<sup>131</sup>I), chromium (<sup>51</sup>Cr), or technetium (<sup>99m</sup>Tc). These particles are nearly completely removed from the circulation by the small vessels in the lungs after intravenous injection and are then broken down to smaller particles which leave the lungs with half-times ranging between five and ten hours.<sup>1</sup> Clinical and experimental studies indicate that pulmonary emboli may cause significant physiological changes, with or without symptoms, in human subjects and animals.<sup>45</sup>Since radioisotope
The "Sense" of Humor— Art &amp;amp; Science
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POSSIBLE RELATION OF CHRONIC COPPER POISONING TO HEMOCHROMATOSIS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Authors: Saskia Hoffmann, Stine Smedegaard, Kyosuke Nakamura, Gulnahar B. Mortuza, Markus Räschle, Alain Ibañez de Opakua, Yasuyoshi Oka, Yunpeng Feng, Francisco J. Blanco, Matthias Mann, Guillermo Montoya, Anja Groth, Simon Bekker-Jensen, Niels Mailand
Journal: The Journal of Experimental Medicine (2016)
Determination of mean pulmonary capillary pressure by a noninvasive technique
Authors: A. M. Abdulla
Journal: JAMA (1980)

The feasibility of estimating the mean pulmonary capillary pressure (PCP) by simultaneous noninvasive recording of the ECG, phonocardiogram, and mitral valve echocardiogram was tested in 36 patients with miscellaneous heart lesions. The recordings were made in close sequence with direct measurement of PCP by a catheter. The interval from the onset of the QRS complex to the echocardiographic point C of mitral valve closure (Q-C) and the time from the aortic valve closure sound to the E point of the mitral echocardiogram (A<sub>2</sub>-E) were measured. The difference between these two intervals exhibited a good linear correlation with the PCP. A better correlation was found between the ratio (Q-C)/(A<sub>2</sub>-E) and the PCP, which is potentially useful in the noninvasive determination of PCP in several forms of heart disease. (<i>JAMA</i>243:1539-1542, 1980)
Introduction: Problems in Definition, Classification, and Etiology
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tracheal Reconstruction with Heavy Marlex Mesh
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal