tbuckley/cabot-search huggingface dataset:
Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-β and FOXP3
Authors: Marina Ostroukhova, Carole Seguin-Devaux, Timothy B. Oriss, Barbara Dixon-McCarthy, Liyan Yang, Bill T. Ameredes, Timothy E. Corcoran, Anuradha Ray
Journal: Journal of Clinical Investigation (2004)

Under normal circumstances, the respiratory tract maintains immune tolerance in the face of constant antigen provocation. Using a murine model of tolerance induced by repeated exposure to a low dose of aerosolized antigen, we show an important contribution by CD4+ T cells in the establishment and maintenance of tolerance. The CD4+ T cells expressed both cell surface and soluble TGF-β and inhibited the development of an allergic phenotype when adoptively transferred to naive recipient mice. While cells expressing cell surface TGF-β were detectable in mice with inflammation, albeit at a lower frequency compared with that in tolerized mice, only those from tolerized mice expressed FOXP3. Blockade of TGF-β in vitro and in vivo interfered with immunosuppression. Although cells that expressed TGF-β on the cell surface (TGF-β+), as well as the ones that did not (TGF-β–), secreted equivalent levels of soluble TGF-β, only the former were able to blunt the development of an allergic phenotype in mice. Strikingly, separation of the TGF-β+ cells from the rest of the cells allowed the TGF-β– cells to proliferate in response to antigen. We propose a model of antigen-induced tolerance that involves cell-cell contact with regulatory CD4+ T cells that coexpress membrane-bound TGF-β and FOXP3.
The monoethylglycinexylidide test does not correctly evaluate lidocaine metabolism after ischemic liver injury in the rat
Authors: I Leclercq
Journal: Hepatology (1997)

Although the monoethylglycinexylidide (MEGX) test defined as a single determination of MEGX plasma concentration after lidocaine injection has been proposed as a liver function test, some discrepancies appeared in assessing the quality of liver donor for transplantation as well as the severity of liver disease. The present study used a severe ischemia- reperfusion liver injury (IRI) in rat to evaluate the various factors able to influence the level of MEGX. The metabolism of lidocaine was studied on microsomes isolated from intact rats and from rats submitted to this liver injury. A significant reduction of the various pathways transforming lidocaine but also MEGX was demonstrated. Lidocaine inhibited the MEGX transformation both in intact and injured liver microsomes. In vivo, plasma MEGX concentrations, determined by high-performance liquid chromatography (HPLC), were lower in IRI than in controls up to 80 minutes after lidocaine injection but not later. By contrast, using the usual commercial fluorescence polarization immunoassay (FPIA), MEGX concentrations were paradoxically higher in IRI than in controls. Moreover, MEGX values obtained using FPIA were threefold higher in controls and ninefold higher in IRI than with HPLC. It was shown that these differences were related to the detection by FPIA of free and mainly of conjugated hydroxy-MEGX that accumulated in plasma from rats submitted to an IRI. These data emphasize the complexity of factors influencing the appearance and disappearance of MEGX because of delayed MEGX formation with liver injury but also to inhibition of its further metabolization. The choice of the sampling time for MEGX determination is critical and has to be optimized in every type of liver injury. Moreover, a specific technique, such as HPLC, will avoid cross-reactivity with other metabolites, which may be particularly abundant when the biliary excretion is impaired.
AMBIDEXTERITY.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatise on Diseases of the Skin.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Social class affects old people's use of general practice
Journal: BMJ (1999)

Community care of long stay psychiatric patients presents few problems Some attribute the increasing number of homeless people in Britain and the high profile killings by mentally ill people to the closure of psychiatric hospitals and the lack of alternative care.On the basis of a 13 year follow up study, Trieman et al (p 13) show the outcomes for former patients of two psychiatric hospitals and dispel some of the main concerns about their fate in the community.The authors say that a change in policy towards custodial care is unjustified as much as it is unrealistic.
(25) Argyria
Authors: C.N.A. Matthews, R.R.M. Harman
Journal: British Journal of Dermatology (1977)

Journal Article (25) Argyria Get access C.N.A. Matthews, C.N.A. Matthews Weston‐super‐Mare General Hospital Search for other works by this author on: Oxford Academic Google Scholar R.R.M. Harman R.R.M. Harman Weston‐super‐Mare General Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue s15, 1 December 1977, Page 60, https://doi.org/10.1111/j.1365-2133.1977.tb14333.x Published: 01 December 1977
Sublimation
Authors: Beatriz Rodriguez
Journal: Annals of Internal Medicine (2011)

Ad Libitum5 July 2011SublimationBeatriz Rodriguez, MDBeatriz Rodriguez, MDFrom Rockford, IL 61107.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-1-201107050-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Freud, for all his bombast,did get one precept rightthere is in sublimation—the key to civil lifewhen groping for desiresthat lie beyond our reachthere is a simple reflex arcto satisfy that thirstthere is an ancient, rugged paththat wiser men have treadit straightens out the errant oneit leads the lost one homeIt stills in us the ache of nightwhen furies steal our sleepit redirects our passions,shapes promises to keepwords become our weapons,a verse, a light caressa poem, that moment to beholdthose buttons on her dressand the dance of cloaked ... Author, Article, and Disclosure InformationAffiliations: From Rockford, IL 61107.Current Author Address: Beatriz Rodriguez, MD, 1826 Rothschild Lane, Rockford, IL 61107. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 July 2011Volume 155, Issue 1Page: 60KeywordsInterleukinsPainReflexesSleep ePublished: 5 July 2011 Issue Published: 5 July 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
LARGE AND SMALL BRAINS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IS APPENDICITIS ON THE INCREASE?
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts
Journal: Annals of the Rheumatic Diseases (1958)

This discussion of the relationship between chorea and acute rheumatism is based on a review of thirty cases of chorea in children seen since 1948 at the Clinic for Children's Diseases, Montpellier.Of these cases, seven were examples of "pure" chorea (but two patients in this group subsequently developed recurrences in which signs of rheumatic carditis appeared), and the remaining 23 cases occurred in children with other evidence of acute rheumatism.In twelve cases, polyarthritis and carditis preceded the onset of chorea by periods varying from several weeks to 4 months, in two acute rheumatism occurred simultaneously with the chorea, and in nine at the onset of the chorea there appeared to be an estab- lished lesion of the mitral valve.The authors advance arguments to support the view that chorea represents a peculiar manifestation of a post- streptococcal state and that it occurs some weeks or even months later in the evolution of this state than does acute rheumatism.It is suggested that the rare but occasional occurrence of acute rheumatism and chorea simulta- aneously may be explained by the assumption that the
Beta-blockers in immediate treatment of myocardial infarction.
Authors: F Wright
Journal: BMJ (1980)

poststerilisation syndrome,"9 which I believe does exist.A combined approach by gynaecologists and general practitioners is likely to be most fruitful.The analysis of consulting patterns and referrals for gynaecological complaints in sterilised women, both before and after operation, and in controls is currently being explored in this practice.
Abstract 1951: Circulating Dendritic Cells May Play an Important Role in Pathophysiology in Heart Failure in Humans
Authors: Yusuke Sugi, Hideo Yasukawa, Hisashi Kai, Daisuke Fukui, Nobuyoshi Futamata, Kazuhisa Mawatari, Toyoharu Ohba, Mitsuhisa Koga, Tsutomu Imaizumi
Journal: Circulation (2007)

Dendritic cells (DCs) are the most potent antigen-presenting cells and play a central role in initiating the primary immune response. Although increasing evidence supports immune-mediated inflammation plays an important role in the pathophysiology of heart failure, little is known regarding the source and mechanism that trigger immune responses. The present study examined whether circulating DCs have any role in the pathophysiology in heart failure in humans. Methods and Results: With multi-color flow-cytometry we determined the numbers of circulating myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in decompensated heart failure patients with NYHA class III or IV on admission (n=27) and the age-matched control subjects (n=21). DC activation markers such as CD40 and CCR7 were also measured. On admission, circulating mDC and pDC counts were significantly lower in decompensated heart failure patients compared to control subjects (12417 ± 2849 versus 5394 ± 3547 and 3321 ± 1491 versus 1800 ± 1474/ml, respectively, p&lt;0.01). Circulating DCs were activated in the decompensated heart failure patients compared to control subjects (CD40; 1.6 ± 1.8 versus 8.5 ± 9.2, CCR7; 3.5 ± 4.1 versus 13.5 ± 10.0, respectively, p&lt;0.05). Heart failure treatment significantly restored the reduction and the activation of circulating DCs (p&lt;0.05). The increases of circulating DCs numbers after treatment were correlated with the decreases in B-type natriuretic peptide (BNP) and troponin-T (r=0.64, p&lt;0.01 and r=0.46, respectively, p&lt;0.05) and with the increase in left ventricular ejection fraction (LVEF) (r=0.73, p&lt;0.01). Furthermore, we found that patients with smaller circulating DCs numbers (less than 10000/ml) after heart failure treatment had poor prognosis compaired with those who had greater DCs numbers (more than 10000/ml) during the 6-month follow-up (p&lt;0.01). Thus, we found that changes of circulating DCs numbers were well correlated with cardiac injury and function, and that poor recovery of the circulating DCs number after treatment predicted recurrence of decompensated heart failure. Conclusion : These findings suggest that circulating DCs may play an important role in pathophysiology in heart failure in humans.
Tyrosine phosphorylation is important for signal transduction in endotoxin stimulated Kupffer cells Laboratory for Cancer Biology, New England Deaconess Hospital, Harvard Medical School, Boston Ma.
Journal: Hepatology (1995)

Specific biological responses to the erbB3-erbB4 ligand heregulin (HRG) have been postulated to be due to the formation of heterodimers of those receptors with erbB2. To test the role that erbB2 plays in the response to HRG in a human breast carcinoma cell line, antisense oriented erbB2 was stably transfected into AU565 cells. In the absence of HRG, inhibition of erbB2 expression slowed cell growth, leading to accumulation of cells in the G2/M phase, and suppressed colony growth in soft agar. Low concentrations of HRG induced cell proliferation in both the erbB2-nonexpressing cells and the parental AU565 cells. In contrast, high concentrations of HRG failed to induce differentiation of the erbB2-nonexpressing cells as compared with the parental cells. ErbB3 expression was significantly decreased in the erbB2 nonexpressing cells. ErbB3 was constitutively tyrosine phosphorylated in both the parental AU565 cells and in the erbB2 nonexpressing cells. HRG further increased tyrosine phosphorylation of erbB3 with a maximum response at 1 ng/ml of HRG in erbB2 nonexpressing cells, as compared with 10 ng/ml of HRG in AU565 cells. This finding suggested that the biochemical responsiveness of erbB3 to HRG was changed, but not abrogated, by inhibition of erbB2 expression. These results suggest that inhibition of erbB2 expression modulates, but does not abolish, HRG mediated signal transduction pathways in a human breast cancer cell line.
Aortic Stiffness Is Increased in Hypertrophic Cardiomyopathy With Myocardial Fibrosis
Authors: Thananya Boonyasirinant, Prabhakar Rajiah, Randolph M. Setser, Michael L. Lieber, Harry M. Lever, Milind Y. Desai, Scott D. Flamm
Journal: Journal of the American College of Cardiology (2009)
Contact Lenses
Authors: Perry Rosenthal
Journal: New England Journal of Medicine (1965)

LENSES designed to be worn in a position contiguous with the external portion of the eye were fabricated as far back as the latter part of the nineteenth century. The reason for the early interest in contact lenses is the significant optical advantages that they offer in many cases of high refractive errors, irregular corneas and unilateral aphakia. However, it was not until 1938, when plastic resins became available, that the manufacture of these lenses became practical. The use of polymethylmethacrylate plastics permitted the fabrication of lenses that duplicate the molded contour of each individually fitted eye. However, the enthusiastic . . .
High Diagnostic and Prognostic Value of Steroidogenic Factor-1 Expression in Adrenal Tumors
Authors: Silviu Sbiera, Sebastian Schmull, Guillaume Assie, Hans-Ullrich Voelker, Luitgard Kraus, Melanie Beyer, Bruno Ragazzon, Felix Beuschlein, Holger S. Willenberg, Stefanie Hahner, Wolfgang Saeger, Jerome Bertherat, Bruno Allolio, Martin Fassnacht
Journal: Endocrine Reviews (2010)

Context:No immunohistochemical marker has been established to reliably differentiate adrenocortical tumors from other adrenal masses. A panel of markers like melan-A and inhibin-a is currently used for this purpose but suffers from limited diagnostic accuracy. We hypothesized that expression of steroidogenic factor-1 (SF-1), a transcription factor involved in adrenal development, is of value for the differential diagnosis of adrenal masses and predicts prognosis in adrenocortical carcinoma (ACC).
Proposal to boost children's health.
Journal: Environmental Health Perspectives (1999)

In a bid to provide better protection for children's health, U.S. Senators Barbara Boxer (D-California) and Frank Lautenberg (D-New Jersey) introduced the Children's Environmental Protection Act (CEPA), on 24 May 1999. CEPA is an amendment to the Toxic Substances Control Act of 1976 and seeks to protect children from exposures to hazardous substances such as toxic air pollutants and pesticides sprayed in schools. The act would also provide parents with the information necessary to make decisions about how to protect their children against such health threats.
A Prospect of Violence
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 91: Cardiac-directed Expression of Adenylyl Cyclase Catalytic Domain Reduces Left Ventricular Systolic and Diastolic Dysfunction in Pressure-overload
Authors: Zhen Tan, Young Chul Kim, Ngai C Lai, Zhenxing Fu, Dimosthenis Giamouridis, Tracy Guo, Bing Xia, Mei Hua Gao, H. Kirk Hammond
Journal: Circulation Research (2017)

Background and Objective: A fusion protein (C1C2) constructed by fusing the intracellular C1 and C2 segments of adenylyl cyclase type 6 (AC6), retains beneficial effects of AC6 expression, without increasing cAMP generation. For example, transgenic mice with cardiac-directed C1C2 expression have normal left ventricular (LV) function despite reduced cAMP generation. Furthermore, sustained isoproterenol (Iso) infusion reduces LV function in normal mice, but, in contrast, C1C2 mice show increased LV function with sustained Iso infusion. The effects of C1C2 expression in pressure-overload is unknown. Methods: LV pressure overload was induced by transaortic constriction (TAC) in C1C2 mice and in transgene negative mice. Three weeks after TAC, LV systolic and diastolic function were measured, and Ca2+ handling was assessed in isolated cardiac myocytes. Results: C1C2 expression reduced LV hypertrophy (p=0.017), increased LV peak pressure development (+dP/dt, p=0.018), and improved LV peak pressure decay (-dP/dt, p=0.038) in the pressure-overload ( Table ). Cytosolic peak Ca2+ concentration was increased (p=0.047), and time to peak Ca2+ transient and Tau were decreased (p=0.002 and p=0.003, respectively) in cardiac myocytes isolated from pressure-overloaded hearts ( Table ). Conclusions: Cardiac-directed C1C2 expression reduces LV hypertrophy, improves Ca2+ handling, and increases LV systolic and diastolic function in pressure-overload. These data provide a rationale for further exploration of C1C2 gene transfer as a potential treatment for heart failure.
Appropriateness of Antiepileptic Drug Level Monitoring-Reply
Authors: David W. Bates
Journal: JAMA (1996)

<h3>In Reply.</h3> —Dr Gambino has two main concerns about our study: that the low ordering appropriateness rate of 27% was found largely because blood samples were drawn at an inappropriate time, and that we did not address the issue of undermonitoring, which he considers more serious than over-monitoring. In fact, most levels were judged inappropriate because they were redundant (performed 1 or more days before they were indicated) and not simply drawn at the wrong time. This occurred because routine once-per-day determination of antiepileptic drug levels was performed regularly without pharmacological or clinical justification, accounting for the majority of the inappropriate determinations. Moreover, we did not consider the ordering of a level inappropriate if it was sampled at the wrong time, but incorrect sampling was an additional important problem: of the 27% of levels with an appropriate indication, 49% were sampled incorrectly. Dr Dorizzi and colleagues describe patterns of inappropriate