tbuckley/cabot-search huggingface dataset:
ESR of Copper and Iron Complexes with Antitumor and Cytotoxic Properties
Authors: William E. Antholine, Balaraman Kalyanaraman, David H. Petering
Journal: Environmental Health Perspectives (1985)

The relatively few iron and copper metal complexes which have been examined in cells and tissues for their redox properties, radical generation properties, and antitumor activity are discussed for studies which utilized electron spin resonance spectroscopy (ESR). A common property of a number of metal complexes, which include bleomycin, adriamycin, and thiosemicarbazones described in this review, is that they are readily reduced by thiol compounds and oxidized by oxygen or reduced species of oxygen to produce radicals. Structural features of these reactions are identified by ESR spectroscopy in model systems and often in cells. Furthermore, ESR spectroscopy has been most useful to probe the environment of the complexes in cells and to measure the rate of reduction of their oxidized forms. As a result of these studies, it is anticipated that more attention will be given to the exploration of redox-active metal complexes as drugs.
Leprosy
Authors: C. H. Binford
Journal: JAMA (1982)

TODAY, leprosy impairs the physical, social, and economic well-being of millions. Those who live in Third World countries suffer most, because living conditions are marginal and health care provision systems are undeveloped or disrupted by political ferment. Most physicians in the United States have had no training or clinical experience in the treatment of leprosy. The influx of immigrants from endemic regions and increased world travel by US citizens make it essential that US physicians become more aware of leprosy and inform themselves of the recent important advances in the art and science of this once-puzzling disease. In 1874, Hansen, in Bergen, Norway, reported that leprosy was caused by a bacillus and therefore was an infectious and not a hereditary disease, as had been thought previously. During the next 70 years, much was learned about the natural history and the clinical and pathological manifestations of leprosy, but no antibacterial drug
Does it matter that medical graduates don’t get jobs as doctors? Yes
Authors: Graham Winyard
Journal: BMJ (2008)

Last year’s shortfall in training places looks set to be repeated. <b>Graham Winyard</b> believes this is a betrayal of students’ expectations, but <b>Alan Maynard (</b>doi: 10.1136/bmj.39555.500613.AD) thinks it is inevitable if patients are to get the best care
Restraining Infarct Expansion Preserves Left Ventricular Geometry and Function After Acute Anteroapical Infarction
Authors: Scott T. Kelley, Ramin Malekan, Joseph H. Gorman, Benjamin M. Jackson, Robert C. Gorman, Yasuyuki Suzuki, Theodore Plappert, Daniel K. Bogen, Martin G. St. John Sutton, L. Henry Edmunds
Journal: Circulation (1999)

Background —Expansion of an acute myocardial infarction predicts progressive left ventricular (LV) dilatation, functional deterioration, and early death. This study tests the hypothesis that restraining expansion of an acute infarction preserves LV geometry and resting function. Methods and Results —In 23 sheep, snares were placed around the distal left anterior descending and second diagonal coronary arteries. In 12 sheep, infarct deformation was prevented by Marlex mesh placed over the anticipated myocardial infarct. Snared arteries were occluded 10 to 14 days later. Serial hemodynamic measurements and transdiaphragmatic quantitative echocardiograms were obtained up to 8 weeks after anteroapical infarction of 0.23 of LV mass. In sheep with mesh, circulatory hemodynamics, stroke work, and end-systolic elastance return to preinfarction values 1 week after infarction and do not change subsequently. Ventricular volumes and ejection fraction do not change after the first week postinfarction. Control animals develop large anteroapical ventricular aneurysms, increasing LV dilatation, and progressive deterioration in circulatory hemodynamics and ventricular function. At week 8, differences in LV end-diastolic pressure, cardiac output, end-diastolic and end-systolic volumes, ejection fraction, stroke work, and end-systolic elastance are significant ( P &lt;0.01) between groups. Conclusions —Preventing expansion of acute myocardial infarctions preserves LV geometry and function.
Positional Vertigo
Authors: James B. Snow
Journal: New England Journal of Medicine (1984)

Vertigo that occurs with changes in position and is accompanied by nystagmus may result from peripheral diseases (those affecting the inner ear or eighth cranial nerve) or from central diseases (those affecting the brain stem or cerebellum). The former include Meniere's disease, vestibular neuronitis, cerebellopontine-angle tumors, and benign paroxysmal positional vertigo; the latter include brain-stem and cerebellar neoplasms, demyelinating diseases, trauma, and arteriosclerosis. Peripheral positional vertigo is characterized by an intense subjective sensation of spinning and nystagmus that is rotary and counterclockwise when the patient is recumbent and the head is turned to the right side, and clockwise when the . . .
HELMHOLTZ AND THE PUBLIC LECTURE PLATFORM.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PIONEER CRANIECTOMY FOR RELIEF OF MENTAL IMBECILITY DUE TO PREMATURE SUTURAL CLOSURE AND MICROCEPHALUS.
Authors: L. C. LANE
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health insurance coverage and utilization of health services by Mexican Americans, mainland Puerto Ricans, and Cuban Americans
Authors: F. M. Trevino
Journal: JAMA (1991)

This investigation examines data on 13 000 Mexican Americans, Puerto Ricans, and Cuban Americans between 6 months and 74 years of age who were interviewed from 1982 through 1984 in the Hispanic Health and Nutrition Examination Survey. In addition, data from the 1989 Current Population Survey (N = 145 000) conducted by the US Bureau of the Census are presented for the white and black non-Hispanic populations as well as the three Hispanic national origin groups. The study revealed that over one third of the Mexican-American population, one fifth of the Puerto Rican population, and one fourth of the Cuban-American population is uninsured for medical expenditures compared with one fifth of the black, non-Hispanic population and one tenth of the white, non-Hispanic population. Furthermore, compared with Hispanics with private health insurance, uninsured Hispanics are less likely to have a regular source of health care, less likely to have visited a physician in the past year, less likely to have had a routine physical examination, and less likely to rate their health status as excellent or very good. (<i>JAMA</i>. 1991;265:233-237)
Sublingual Mumps
Authors: J. M. Canning
Journal: BMJ (1953)

On the thirty-fifth day the patient was again given P.A.S., 7.5 g. a day, plus thyroid B.P., 1 gr.(65 mg.) thrice daily.Three days later both drugs were stopped on account of toxic symptoms.After a rest of three days the drugs were again administered, this time being continued for seven days, when again the drugs were stopped on account of toxic symptoms.No enlargement of the thyroid was noted during this period, and it seems that the addition of the thyroid extract prevented the glahd from enlarging.The toxic symptoms noted were again loss of appetite, vomiting, headache, and dizziness, with persistence of the exoph- thalmos; the patient stated that the addition of thyroid REFERENC
STUDIES OF LUNG VOLUME
Authors: A. Garvin, Christen Lundsgaard, Donald D. Van Slyke
Journal: The Journal of Experimental Medicine (1918)

The total capacity, middle capacity, and residual air have been determined in twenty adult women suffering from pulmonary tuberculosis. The chest volumes have been determined in each case and the normal lung volumes calculated by means of the ratios worked out in Paper I and applied to thirty-one men in Paper II. The excursions of the diaphragm have been determined by fluoroscopy in all cases. Of eight patients with incipient tuberculosis, five had lung capacities like those of men in the same group; i.e., about normal total capacity, slightly increased residual air, and consequently somewhat decreased vital capacity. Three had considerably diminished total capacity. In these three patients, however, clinical abnormalities were found (extensive miliary tuberculosis, obstruction of bronchus, fixation of diaphragm in expiratory position). In twelve patients with moderately advanced and advanced tuberculosis, the results agreed with those found in men, the total capacity and vital capacity being decreased, while the residual air was practically normal.
Medical myths
Authors: Rachel C Vreeman, Aaron E Carroll
Journal: BMJ (2007)

Objective To test whether standard information for patients using Crunchie and Aero chocolate bars to explain bone health and risk of fracture is robust.Design Observational study.Setting Domestic kitchen in rural west Wales.Participants 10 Crunchie bars and 10 Aero bars.Main outcome measure Fracture after falls from varying heights.Results Both Crunchie and Aero bars exhibited the same T and Z scores for bone density.Crunchie bars had a lower chocolate mass index than the Aero bars.Crunchie bars are more liable to fracture.Conclusions Using Crunchie and Aero chocolate bars to explain bone structure to patients may be visually attractive but oversimplifies the situation. IntroductIonIt is important that information provided to patients as part of their treatment should be comprehensive and accurate.Within our area of practice relating to osteoporosis and fragility fracture we have noticed a tendency to compare normal, healthy bone to the finely honeycombed structure of a Crunchie (Cadbury Trebor Bassett; Bournville, Birmingham) chocolate bar and to compare abnormal, osteoporotic bone to the coarser structure of an Aero (Nestle UK; York) bar (fig 1). 1 2 Although this explanation is readily appreciated by patients and clinicians it struck us that the comparison may not be completely valid as no work has been published on the fracture potential of each bar.This might mean that with best intentions we are advising patients to aspire to a bone structure that is actually more liable to fracture.To enable us to provide accurate data to our patients we studied the fracture risk for each chocolate bar. MethodsWe randomly purchased 20 chocolate bars (10 Crunchie and 10 Aero) from a reputable high street confectioner; the number of bars was limited by research funds and our rural environment.Each bar was measured to provide information on height
Postgastrectomy Hypoglycemia: Report of Patient Treated with Chlorpropamide
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Statement on exercise. Benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart association.
Authors: G F Fletcher, S N Blair, J Blumenthal, C Caspersen, B Chaitman, S Epstein, H Falls, E S Froelicher, V F Froelicher, I L Pina
Journal: Circulation (1992)
Criteria for the diagnosis of malnutrition
Authors: S. J. Bell
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We were very interested to read the SPECIAL COMMUNICATION by Mattson and colleagues<sup>1</sup>on the use of oral contraceptives by women with epilepsy. In general, we concur with most of the comments they make. We agree that valproate sodium is not associated with failure of contraception, and a recent article<sup>2</sup>confirms that valproate has no effect on contraceptive steroid metabolism. As Mattson and colleagues point out, most cases of failure of contraception have involved phenytoin or phenobarbital. We recently studied 43 cases of such failure of contraception reported to the Committee on Safety of Medicines in the United Kingdom and compared the data to overall prescription rates for anticonvulsants in the period from 1973 through 1984. It is apparent, as Mattson et al suggest, that the predominance of phenytoin and phenobarbital involvement in cases of failure of contraception is largely due to the far higher
Fluorine 18 bone scans in the detection of early metastatic bone tumors
Authors: G. B. Hopkins
Journal: JAMA (1972)

Fluorine 18 bone scans are valuable adjuvants in the detection of early metastatic bone disease. In 104 patients with metastatic bone tumors, the scans and roentgenograms correlated in 75% of cases. Where discrepancies occurred, the scans were correct four times as often as the roentgenograms. Osteoblastic lesions were readily defined whereas osteolytic lesions yielded negative scans in four patients with bone metastases. Fluorine 18 scintiphotos also proved more sensitive than serum acid or alkaline phosphatase determinations.
Personal Use of Drug Samples by Physicians and Office Staff
Authors: Hemendra J. Mehta
Journal: JAMA (1997)

<h3>To the Editor.</h3> —I take serious offense regarding the article by Dr Westfall and colleagues<sup>1</sup>on the personal use of drug samples by physicians and office staff. In our office we use many samples, and 90% or more are for the benefit of the patients. Samples are a great boon to needy patients, and they are hardly used by our office staff and physicians. The Food and Drug Administration and the government will definitely look at this most unscientific report very negatively. This is only going to hurt the needy patients who get serious benefit from such samples offered by the pharmaceutical companies.
Recent Developments in the Understanding of the Pathogenesis and Treatment of Anaerobic Infections
Authors: Barbara Styrt, Sherwood L. Gorbach
Journal: New England Journal of Medicine (1989)

(Second of Two Parts)Another clinical syndrome for which a putative anaerobic pathogen has been tentatively identified is nonspecific vaginitis, now often referred to as anaerobic vaginosis. In the past this condition was thought to be caused by Gardnerella vaginalis, but more recently by abnormal anaerobic vaginal flora, on the basis of culture results and an increased ratio of succinate to lactate in vaginal specimens.158 , 159 Several observers have found curved, motile anaerobic bacilli in association with this disease.160 161 162 163 164 165 166 These organisms have been assigned to the genus mobiluncus.167 Treatment with ampicillin or metronidazole has resulted in the clearance of these . . .
Radiotherapy
Authors: Leonard R. Prosnitz, Daniel S. Kapp, Joseph B. Weissberg
Journal: New England Journal of Medicine (1983)

Gynecologic Radiation OncologyCancer of the Uterine CervixTreatment results for invasive carcinoma of the cervix have been good in the past, with an overall disease-free five-year survival rate of 65 per cent.3 There has not been much improvement in the stage-for-stage survival rate in the past 20 years. Failure to eradicate the disease in the pelvis, with or without associated distant metastases, still accounts for more than 85 per cent of the deaths occurring in advanced disease (Stages III and IV).87 The introduction of megavoltage radiation equipment has had less than the desired impact, probably because intracavitary radium was . . .
Renal duplex Doppler ultrasonography: A noninvasive predictor of kidney dysfunction and hepatorenal failure in liver disease
Authors: J Platt
Journal: Hepatology (1994)

Hepatorenal failure, a well-recognized complication of established liver disease, is characterized by early renal hemodynamic changes (vasoconstriction) before clinically recognized kidney disease. This renal vasoconstruction (increased renal vascular resistance) should be detectable noninvasively by Doppler ultrasonography. We studied whether renal Doppler ultrasonography detects abnormalities in patients with nonazotemic liver disease and its prognostic value for subsequent kidney status. We observed by renal Doppler ultrasonography 180 patients who had liver disease without azotemia. A simple parameter, resistive index, was derived for each subject on the basis of Doppler waveform analysis. Traditional parameters used to assess patients with liver disease were also recorded at the time of Doppler ultrasonography. Subsequent kidney outcomes were kidney dysfunction (doubling of initial creatinine level to 1.5 mg/dl [133 μmol/L]) or more and the presence or absence of the hepatorenal syndrome. Abnormal results of Doppler examinations (elevated resistive index) were seen in 76 (42%) of the 180 patients. Kidney dysfunction developed in 55% (42/76) of the patients with an elevated resistive index and 6% (6/104) of those with normal results of Doppler study (p<0.00005). Hepatorenal syndrome developed in 26% (20/76) of subjects with an elevated resistive index and 1% (1/104) of those with a normal resistive index (p<0.00005). Cox regression analysis identified resistive index as a significant independent predictor of subsequent hepatorenal syndrome (p<0.00005) and kidney dysfunction (p<0.00005). Renal duplex Doppler ultrasonography can noninvasively identify a subgroup of nonazotemic patients with liver disease that is at significantly higher risk for subsequent development of kidney dysfunction and the hepatorenal syndrome. (Hepatology 1994;20:362–369.)
Reference Committees 1984 Annual Meeting
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal