tbuckley/cabot-search huggingface dataset:
Le rachitisme et la tétanie.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies in the Behavioral Toxicology of Environmental Contaminants
Authors: Bernard Weiss, Tina E. Levine
Journal: Environmental Health Perspectives (1976)

Behavioral toxicology represents a relatively new research area in the West, and a new source of information pertinent to standard setting. Despite this abbreviated history, however, it can call on a rather advanced technology, largely provided by the rapid and extensive development of behavioral pharmacology during the past two decades. As exemplified by the U.S. contribution to the joint study of carbon disulfide, the approach derived from this background relies on the acquisition of dose--effect data with a preparation yielding stable baseline performance. The first study in this collaborative series employed pigeons trained to peck a response device consisting of a transilluminnated plastic disk. Various relationships between this response and the occasions on which it led to the delivery of food were explored in order to ascertain which behavioral variables were most sensitive to acute exposures. In addition, a central nervous system drug, whose neurochemical mode of action is believed to parallel that of carbon disulfide, was tested in the same preparations. Further research on these questions is being continued with monkeys.
Hereditary Angioedema
Authors: Paula J. Busse, Sandra C. Christiansen
Journal: New England Journal of Medicine (2020)

Hereditary angioedema is a rare genetic disease that may include recurrent attacks of cutaneous angioedema, severe abdominal pain, and airway compromise. Prophylaxis and treatment include C1 inhibitor replacement and inhibition of the kallikrein and bradykinin pathways.
Abstracts
Journal: Journal of Clinical Investigation (1968)

Complement (C') participates in many diseases, but its importance for health is uncertain.Observations were made in a young man with Klinefelter's syndrome who has had repeated pyogenic infections since infancy.No abnormalities were found in immunoglobulins, in delayed hypersensitivity, or in dye reduction by his granulocytes during phagocytosis of latex particles.Serum activities of C'1, C'4, and C'2 were normal.However, C'3 con- centration was only 25% of normal, and since 65% of that was in the inactive (C'3,) form, the true level of C'3 was 9% of normal.The level of C'3 remained low during and between episodes of infection.The patient's red cells were strongly agglutinated by anti-C'3, and by "nongamma" Coombs sera, but red cell survival was normal.When purified C'3, labeled with 'NI, was injected into the patient, it was catabolized rapidly, with 35% of the "25I appearing in the C'31 fraction within 2 hr.The calculated rate of C'3 synthesis was normal.The patient's serum was very deficient in hemolytic C' activity, in bactericidal activity, and in C'-mediated leukotaxis.Granulocytes from the patient or from normals failed to ingest and kill pneumococci that were exposed to anti- serum in the presence of the patient's serum, whereas granulocytes from either source did so with normal serum present.Although the addition of purified C'3 to the patient's -serum produced some improvement in C'- mediated functions, much greater improvement resulted from the addition of a heat-labile 5-6S beta pseudoglobulin.These studies indicate that increased susceptibility to infection may be associated with deficient C' activity.Although manifested by a continuously increased catabolism and depletion of C'3 and by the absorption of C'3 on the patient's red cells, the underlying abnormality is unknown.It may represent a deficiency of a protein involved in the activation of C'3.2. The Effects of Polyene Antibiotics on Electrical and Osmotic Properties of Thin Lipid Membranes.
Just Who Has Copped Out?
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nordisk Medicin, Stockholm
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Das Krebsproblem
Authors: Charles Huggins
Journal: JAMA (1963)

This is the second edition of a splendid book about cancer. The author is a devoted man of tireless energy who has had a lifelong interest in tumors and intimately knows the literature of cancer. But the chief value of this work is its analysis and synthesis of knowledge made possible by extensive personal experience in treating cancer patients. Bauer has tried to assemble in a single volume all known facts which might be of value in the diagnosis, treatment, and understanding of cancer in man. He has largely succeeded in a task which few, if any, other authorities could perform. The great difficulty for cancer-research workers is to achieve a marriage between clinic and laboratory. To para-phrase the somewhat hyperbolic remarks of another famous German surgeon, F. Sauerbruch, those who know cannot cure and those who cure do not know. But Bauer knows and can cure. Bauer is most
Extraneous Slug Line
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DNA methylation profile predicts risk of recurrence in tamoxifen-treated, node-negative breast cancer patients
Authors: S. Maier, I. Nimmrich, A. Marx, S. Eppenberger-Castori, F. Jaenicke, A. Paradiso, F. Spyratos, J. Foekens, M. Schmitt, N. Harbeck
Journal: Journal of Clinical Oncology (2004)

525 Background: Today, many women with node-negative, hormone receptor positive breast cancer receive adjuvant chemotherapy followed by endocrine therapy. However, the majority of these patients would never have experienced a relapse and would have been sufficiently treated with endocrine therapy alone. Aim of our study was to identify DNA methylation markers associated with a low risk of recurrence after tamoxifen monotherapy. Methods: As a first step, we performed a genome-wide screening for DNA methylation markers associated with the risk of recurrence after tamoxifen monotherapy. The best candidates were then validated in a population of 278 patients using a microarray approach. Results: We identified several DNA methylation markers with a strong relation to clinical outcome (cox proportional hazard model, p<0.05). In a multivariate model, DNA methylation contributed significant information to conventional factors such as grade, tumor size, or estrogen receptor expression level. Furthermore, by combining three markers into a methylation score and defining a cut-off, we identified a group with excellent outcome when treated with tamoxifen alone (disease-free survival 95 % at 10 years, versus 62 % in the poor prognosis group). Validation in an independent patient cohort is currently in progress. So far, the best marker has already been validated (p<0.05). Conclusions: These results provide substantial evidence that DNA methylation could be used to predict outcome in node-negative patients with tamoxifen monotherapy, and to identify low risk groups which may not require additional cytotoxic treatment. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Epigenomics AG Epigenomics AG Epigenomics AG Epigenomics AG Epigenomics AG
RABIES 1968 MODEL
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship Between Quantity of Penicillinase Produced by Staphylococci and Sensitivity to Five Penicillins
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aortic Valve Replacement With the Freestyle Stentless Bioprosthesis
Authors: Kwok L. Yun, Colleen F. Sintek, Alden D. Fletcher, Thomas A. Pfeffer, Gary S. Kochamba, Manly R. Hyde, Jesus O. Torpoco, Siavosh Khonsari
Journal: Circulation (1999)

Background —Stentless aortic valves were designed to provide a more physiological flow pattern and lower transvalvular gradient, which may have an important bearing on postoperative left ventricular function and remodeling. In this study, we prospectively analyzed the 5-year clinical results with the Freestyle valve (Medtronic, Inc) and its hemodynamic performance by serial echocardiography. Methods and Results —Between January 1993 and August 1997, 95 patients with a mean age of 75 years underwent aortic valve replacement with the Freestyle prosthesis. Sixty-four percent of patients received valves ≤23 mm, and 37% had concomitant coronary artery bypass grafting. Average follow-up was 44±18 months (mean±SD), and echocardiography was performed preoperatively, at discharge, at 3 to 6 months, and annually thereafter. The 30-day operative mortality rate was 3%, with an overall actuarial survival rate of 80±6% (mean±SEM) at 5 years. Of the 10 late deaths, only 2 were cardiac related, thereby yielding a freedom from cardiac mortality of 94±3% after 5 years. No patient required reoperation on the aortic valve for any reason, including structural degeneration, nonstructural dysfunction, or prosthetic valve endocarditis. There were 9 thromboembolic and 3 anticoagulant-related bleeding events, none of which was fatal. The actuarial freedom from valve-related morbidity and mortality was 79±4% at 5 years. Hemodynamically, the mean transvalvular gradient significantly decreased after valve replacement and was reduced further by 41% by 6 months with a corresponding increase in effective orifice area. Left ventricular mass index fell to 75% of the preoperative value by 2 years. Conclusions —The Freestyle stentless valve can be implanted safely in the elderly with excellent midterm clinical results. It has superb hemodynamics in terms of residual transvalvular gradient, effective orifice area, and regression of left ventricular hypertrophy.
Evaluation of Anemia of Rheumatoid Arthritis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differentialdiagnose innerer Krankheiten für Ärzte und Studierende.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coordinating Clinical Site Omitted
Journal: JAMA (2016)

Writing Committee for the Diabetic Retinopathy Clinical Research Network; Jeffrey G. Gross, MD; Adam R. Glassman, MS; Lee M. Jampol, MD; Seidu Inusah, MS; Lloyd Paul Aiello, MD, PhD; Andrew N. Antoszyk, MD; Carl W. Baker, MD; Brian B. Berger, MD; Neil M. Bressler, MD; David Browning, MD; Michael J. Elman, MD; Frederick L. Ferris III, MD; Scott M. Friedman, MD; Dennis M. Marcus, MD; Michele Melia, ScM; Cynthia R. Stockdale, MSPH; Jennifer K. Sun, MD, MPH; Roy W. Beck, MD, PhD
Photocoagulation therapy for diabetic eye disease. Early Treatment Diabetic Retinopathy Study Research Group
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reading disorders in children
Authors: A. M. Potts
Journal: JAMA (1968)

Inability of children to read, or to read well, poses a challenging problem to physicians and educators. A recently published symposium<sup>1</sup>serves a highly useful purpose in presenting progressive medical views of this much-vexed subject. The chief participants in dyslexia studies, the physician and the educator, have had views so diametrically opposed that they have found it difficult even to communicate with one another. The experienced physician has seen cases of adults who, previously capable of perfectly confident reading performance, have suffered a cerebral vascular accident and have found their reading ability instantly abolished. This loss of function can be correlated accurately with a specific lesion in the cerebral cortex. Thus, the physician knows that loss of reading function can be the result of definable organic disease. He also knows that in children with reading problems the incidence of refractive error, muscle balance problems, or other specific ocular disease
URIC ACID AND ECZEMA
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal