tbuckley/cabot-search huggingface dataset:
Abstract 16992: Changes in Physical Activity and the Risk of Incident Heart Failure: The Atherosclerosis Risk in Communities (ARIC) Study
Authors: Roberta Florido, Lucia Kwak, Mariana Lazo, Vijay Nambi, Haitham Ahmed, Sheila M Hegde, Gary Gerstenblith, Roger S Blumenthal, Christie M Ballantyne, Elizabeth Selvin, Aaron Folsom, Josef Coresh, Chiadi E Ndumele
Journal: Circulation (2015)

Background: Higher physical activity is associated with a lower risk of heart failure (HF). The effects of changes in physical activity levels over time on HF risk are largely uncharacterized. Hypothesis: We hypothesized that persistently recommended and increasing levels of physical activity over a 6-year period are associated with reduced HF risk. Methods: We evaluated 11,185 ARIC participants (mean age 60; 57% female, 23% black) free of CVD at Visit 3 (1993-95) with available physical activity data at Visit 1 (1987-89) and Visit 3. Exercise physical activity was assessed using a modified Baecke questionnaire and categorized according to AHA recommendations: recommended (≥150 min/wk of moderate + vigorous activity or ≥75 min/wk of vigorous activity); intermediate (1-149 min/wk of moderate + vigorous activity or 1-74 min/wk of vigorous activity); or poor (no moderate or vigorous activity). We created cross-categories of physical activity at Visit 1 and Visit 3. The primary outcome was incident HF occurring after Visit 3 through 12/31/12. We constructed Cox regression models to estimate the hazard ratios and 95% CIs for incident HF associated with each cross-category of physical activity at Visit 1 and Visit 3, adjusting for confounders. Results: Over a median of 18 years, there were 1,625 HF events. Compared to those with poor activity at both visits (reference), those with persistently recommended activity had the lowest HF risk (Table; HR 0.67 95% CI: 0.58-0.78). Additionally, at each level of baseline physical activity, increasing physical activity over time was associated with decreased HF risk: an increase from poor to recommended activity was linked to a 22% lower risk of HF. Conclusion: While maintaining recommended activity levels is associated with the lowest HF risk, initiating and increasing physical activity over time is also linked to risk reduction. Augmenting physical activity in middle age may be an important component of strategies to prevent HF.
PROCESSES OF HEALING IN CARCINOMA.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gonococcal endocarditis with penicillin-induced bone marrow hypoplasia. Role of echocardiography
Authors: A. D. Timmis
Journal: JAMA (1981)

ENDOCARDITIS is a rare complication of gonococcal infection.<sup>1</sup>We describe an unusual case in which treatment was complicated by two severe episodes of drug-induced neutropenia. This report emphasizes the important role of echocardiography in the diagnosis and management of endocarditis. <h3>Report of a Case</h3> An 18-year-old woman was admitted with a three-week history of fever, chest pain, and painful swellings on the left index finger and thumb. One week previously, her right knee had been swollen and painful. Her temperature was 38 °C, splinter hemorrhages were noted, and Osler's nodes were present on the left index finger and thumb. The carotid pulse was regular with a sharp upstroke. The blood pressure was 150/60 mm Hg. There were no signs of heart failure. An ejection systolic murmur and a loud early diastolic murmur were audible over the precordium. The ECG showed sinus rhythm and widespread nonspecific T-wave flattening. The chest
Postures and Practices During Labor Among Primitive Peoples: Adaptations to Modern Obstetrics with Chapters on Taboos and Superstitions and Postpartum Gymnastics
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Gastric Mucosa in Tropical Sprue
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease
Authors: Kenju Hara, Atsushi Shiga, Toshio Fukutake, Hiroaki Nozaki, Akinori Miyashita, Akio Yokoseki, Hirotoshi Kawata, Akihide Koyama, Kunimasa Arima, Toshiaki Takahashi, Mari Ikeda, Hiroshi Shiota, Masato Tamura, Yutaka Shimoe, Mikio Hirayama, Takayo Arisato, Sohei Yanagawa, Akira Tanaka, Imaharu Nakano, Shu-ichi Ikeda, Yutaka Yoshida, Tadashi Yamamoto, Takeshi Ikeuchi, Ryozo Kuwano, Masatoyo Nishizawa, Shoji Tsuji, Osamu Onodera
Journal: New England Journal of Medicine (2009)

The genetic cause of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), which is characterized by ischemic, nonhypertensive, cerebral small-vessel disease with associated alopecia and spondylosis, is unclear.In five families with CARASIL, we carried out linkage analysis, fine mapping of the region implicated in the disease, and sequence analysis of a candidate gene. We also conducted functional analysis of wild-type and mutant gene products and measured the signaling by members of the transforming growth factor beta (TGF-beta) family and gene and protein expression in the small arteries in the cerebrum of two patients with CARASIL.We found linkage of the disease to the 2.4-Mb region on chromosome 10q, which contains the HtrA serine protease 1 (HTRA1) gene. HTRA1 is a serine protease that represses signaling by TGF-beta family members. Sequence analysis revealed two nonsense mutations and two missense mutations in HTRA1. The missense mutations and one of the nonsense mutations resulted in protein products that had comparatively low levels of protease activity and did not repress signaling by the TGF-beta family. The other nonsense mutation resulted in the loss of HTRA1 protein by nonsense-mediated decay of messenger RNA. Immunohistochemical analysis of the cerebral small arteries in affected persons showed increased expression of the extra domain-A region of fibronectin and versican in the thickened tunica intima and of TGF-beta1 in the tunica media.CARASIL is associated with mutations in the HTRA1 gene. Our findings indicate a link between repressed inhibition of signaling by the TGF-beta family and ischemic cerebral small-vessel disease, alopecia, and spondylosis.
Clinical Measurement of Brain Uptake of Radioisotope
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MIXED INFECTION IN PULMONARY TUBERCULOSIS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential control by arterial and portal noradrenaline of hepatic carbohydrate metabolism: Evidence for an indirect hemodynamic mechanism
Authors: H Miura
Journal: Hepatology (1993)

In an earlier study it was found (a) that arterial noradrenaline caused increases in glucose and lactate output slower in onset, smaller in peak height and clearly longer in duration than those caused by portal noradrenaline and (b) that arterial noradrenaline was extracted to a much greater extent than portal noradrenaline. It is possible that the differences in the actions of arterial and portal noradrenaline were due to the different hemodynamic changes; arterial noradrenaline reduced hepatic flow more strongly and with different kinetics than did portal noradrenaline. Therefore the effects of arterial and portal noradrenaline were investigated in isolated rat liver, singlepass perfused through both the hepatic artery (100 cm H2O, 30% flow) and the portal vein (15 cm H2O, 70% flow), after inhibition of the hemodynamic alterations by the Ca2+ antagonist nifedipine. We found (a) that nifedipine inhibited the hemodynamic changes by arterial noradrenaline strongly and those by portal noradrenaline slightly, (b) that the remaining hemodynamic alterations in the presence of high concentrations of the Ca2+ antagonist (100 μmol/L)–slight decrease in portal flow with unaffected arterial flow– were essentially identical after arterial and portal application of noradrenaline, (c) that the pronounced kinetic differences in the alterations by arterial and portal noradrenaline of glucose and lactate balance were diminished by 50 μmol/L nifedipine and abolished by 100 μmol/L of the Ca2+ antagonist and (d) that the different hepatic extractions of arterial and portal noradrenaline were greatly reduced and almost equalized by nifedipine. These observations allow the conclusion that the differences in the metabolic changes by arterial and portal noradrenaline were caused indirectly by the pronounced differences in the hemodynamic altercations after arterial and portal application of this catecholamine. They confirm earlier morphological and biochemical observations that, in principle, arterial and portal blood reach similar areas of liver parenchyma. (HEPATOLOGY 1993;18:1410–1415.)
Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholera Report.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIABETES DETECTION
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Vol. 66, No. 5
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

In the report "Notes from the Field: Mortality Associated with Hurricane Matthew - United States, October 2016" on page 145, the last sentence of the first paragraph should have read "This report summarizes state-confirmed Hurricane Matthew-associated deaths that occurred during October 1-October 21 in Florida, Georgia, North Carolina, and Virginia."
Irritable hip in the adult.
Authors: D Forsyth, N Katz
Journal: BMJ (1972)

Treatment of Urinary Schistosomiasis SIR,-In the leading article "Chemotherapy in Schistosomiasis" (15 January, p. 128) no reference was made to trichlorphon (metriphonate) for treating urinary schistosomiasis.This drug was used to treat hundreds of infected people in Tanzania with results which were uniformly excellent.1-3There were no toxic side-effects when 7.5 mg/kg were given by mouth at intervals of two or more weeks, there was no evidence of cumulative effects, and the capsules being tasteless were readily accepted by patients.Under favourable conditions the permanent cure rate is 100%.The drug is very cheap, much cheaper than antimony, niridazole, or hycanthone.Trichlorphon does not cure patients with intestinal schistosomiasis.'-I am, etc.,
Contents
Authors: Mahvash Jafari, Azra Rabbani, Kohzo Takebayashi, Yoshimasa Aso, Toshihiko Inukai, Paul Williams, Takeshi Tokudome, Takeshi Horio, Fumiki Yoshihara, Shin-Ichi Suga, Yuhei Kawano, Masakazu Kohno, Kenji Kangawa, Tetsuo Ohkuwa, Hiroshi Itoh, Takako Yamamoto, Chiyoko Minami, Yoshihiko Yamazaki, Shigenobu Kimoto, Ryoichi Yoshida, Alexandra Ward, Holly Syddall, Peter Wood, Elaine Dennison, David Phillips
Journal: Metabolism (2004)
INFORMATION ABOUT THE SUPERINTENDENT OF DOCUMENTS SUBSCRIPTION SERVICE
Journal: JNCI Journal of the National Cancer Institute (1989)

INFORMATION ABOUT THE SUPERINTENDENT OF DOCUMENTS SUBSCRIPTION SERVICE Get access JNCI: Journal of the National Cancer Institute, Volume 81, Issue 2, 18 January 1989, Page 174, https://doi.org/10.1093/jnci/81.2.174 Published: 18 January 1989
Nazi Origins of an Anatomy Text: The Pernkopf Atlas
Authors: William E. Seidelman
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The abuses of medicine perpetrated during the Hitler regime pervaded the entire medical profession of the Third Reich including the academic elite. One legacy of that tragic era endures today through the continued publication of a critically acclaimed atlas,<i>Pernkopf Anatomy</i>,<sup>1</sup>named after the anatomist Professor Eduard Pernkopf of the University of Vienna. The original Pernkopf work contains more than 800 detailed paintings of dissections.<sup>2</sup>A leading Nazi, Pernkopf became dean of the University of Vienna Faculty of Medicine after Germany annexed Austria in 1938.<sup>3</sup>From that position he led the purge against the Jewish faculty in Vienna.<sup>4</sup>Pernkopf s artists expressed their political sympathies by incorporating Nazi icons (such as the letters "SS" or a swastika) as part of their signatures in the original volume. Recent editions include paintings from the earlier volumes with most of the Nazi icons eliminated. The precise
PRESENT STATUS OF WIDAL REACTION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal