tbuckley/cabot-search huggingface dataset:
Epidemic Neuropathy in Cuba
Authors: Gustavo C. Roman
Journal: Annals of Internal Medicine (1995)

Letters1 November 1995Epidemic Neuropathy in CubaGustavo C. Roman, MDGustavo C. Roman, MDSan Antonio, TX 78205Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-9-199511010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The comments on my article on the Cuban neuropathy epidemic are appreciated. Dr. Perez-Stable feels that internal political decisions in Cuba were the main factor precipitating the epidemic. This may be true; however, quantifying the effect of the embargo, compared with that of other factors on the island and overseas is a subjective judgment. The Cuban government could not provide appropriate food supplies to the population in the months before the epidemic began, but it is undeniable that the Torricelli amendment greatly affected food purchases and increased costs. As Dr. De Long notes, shortages continue to affect all ... Author, Article, and Disclosure InformationAuthors: Gustavo C. Roman, MDAffiliations: San Antonio, TX 78205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNutritional Amblyopia and B Complex Vitamin Deficiencies 1 November 1995Volume 123, Issue 9Page: 734KeywordsFoodHealth careNeuropathy ePublished: 15 August 2000 Issue Published: 1 November 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Authors' response
Authors: Nicola Principi, Susanna Esposito
Journal: Thorax (2011)

end-of-life care may be more appropriate, but there are many other important issues that explain the observed outcomes.End of life in chronic obstructive pulmonary disease (COPD) exacerbations is a difficult area of care for which the guidelines are currently vague and where our own data have shown that in large-scale studies all predictors of outcome combined only explain a minority of the variance in outcome. 3 Finally studies of patient choice when offered IMV for respiratory failure in COPD have shown patient preference for intervention beyond that considered appropriate by intensivists in many cases. 4 In essence, this is an area where prospective research is required to better understand both the wishes of patients and the costs and benefits of interventionist or palliative choices.
Epitopes in medicine: the example of the lupus anticoagulant
Authors: J. D. Bessman
Journal: JAMA (1988)

In this issue ofThe Journal, Triplett et al<sup>1</sup>discuss the relationship among an established laboratory test (lupus anticoagulant), an experimental laboratory test (anticardiolipin antibody), and a clinical phenomenon (thrombosis). To understand the conclusion of their work, a little background is needed. They observe that the target of the anticardiolipin assay may be an "epitope" of the lupus anticoagulant. An epitope (from the Greek word for "nearby place") is an antigenic determinant, a structure that can be identified by an antibody. However, the antigenic determinant may be unrelated except by proximity, not by cause, to some other structure of interest. See also p 550. Why the interest in epitopes? There is rapidly increasing interest in using specific antibodies for both therapy<sup>2,3</sup>and diagnosis. With the development of monoclonal antibodies, much smaller targets can be used. An antibody to a given molecule may be directed only to part of
American Review of Respiratory Diseases, New York
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notices
Authors: Jose Ferna ´ndez-Checa, Francisco Romero, B Ames, P Baeuerle, E Cadenas, A Cederbaum, R Chawla, W Droge, L Ernster, H Esterbauer, J Ferna ´ndez-Checa, W Fiers, L Flohe, N Kaplowitz, S Korsmeyer, S Lipton, J Loscalzo, J Mato, S Orrenius, L Packer, J Reed, S Schencker, D Schubert, P Talalay, M Tredger, H Tsukamoto, Jose Ferna ´ndez-Checa, Javier Romero, Sheila Sherlock, Irwin Arias, Roberto Groszmann, Ralph Kirsch, Juan Rodes, Peter Scheuer, Neil Mcintyre, J Boyer, A Lok, K Okuda, R Schmid, R Williams
Journal: Hepatology (1997)

Hotel Melia Los Lebreros Organizers:
Abstract LB-363: DNA-damage foci persistence and accelerated senescence as determinants of radiosensitization by PARP inhibitors
Authors: Elena V. Efimova, Helena J. Mauceri, Juan C. Barreto, Edwardine Labay, Jacek Sikora, Satoe Takahashi, Don W. Wolfgeher, Vytautas P. Bindokas, Thomas E. Darga, Michael A. Beckett, Harold G. Sutton, Everett E. Vokes, Mitchell C. Posner, Ralph R. Weichselbaum, Stephen J. Kron
Journal: Cancer Research (2011)

Abstract Along with apoptosis and necrosis, accelerated senescence may be a desirable outcome when replicative cancer cells undergo unrepairable DNA double strand breaks (DSBs) after treatment with ionizing radiation (IR) or chemotherapy. In both normal and cancer cells, DSBs promote the assembly of Ionizing radiation induced foci (IRIF), domains of modified chromatin that serve a key role in DNA damage signaling and DNA repair. IRIF persistence is a critical determinant of accelerated senescence, making targeting IRIF resolution an attractive strategy to sensitize cancer cells to genotoxic therapy. As an IRIF reporter, we constructed an inducible GFP fusion to the IRIF-binding domain of 53BP1 (GFP-IBD) which we have expressed in breast, head and neck, prostate, glioma and pancreatic cancer cell lines. Typically, within minutes after IR exposure, GFP-IBD relocalizes to form fluorescent nuclear foci, which disperse over several hours. Anti-GFP immunoprecipitation and proteomic analysis of IRIF revealed chromatin modifiers and DNA damage response proteins at DSBs including the poly(ADP-ribose) polymerase PARP1. To block DSB repair in cancer cells and tumors, we treated cells with veliparib (ABT-888), one of several PARP inhibitors currently in clinical trials. Veliparib markedly enhanced IRIF persistence and increased cell senescence in the majority of cancer cell lines tested. Treatment of tumor xenografts in nude mice with veliparib and IR induced persistent foci, increased senescence in tumor and stroma, and delayed tumor regrowth. Our results suggest that the efficacy of PARP inhibitors may partially depend on a competent senescence response to accumulated DNA damage, validating this response as a desirable outcome of genotoxic therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-363. doi:10.1158/1538-7445.AM2011-LB-363
Psychological Dysfunction Accompanying Subcortical Dementias
Authors: J. Cummings
Journal: Annual Review of Medicine (1988)

Subcortical dementia occurs both in disorders affecting the basal ganglia (for example, Parkinson's disease, Huntington's disease, and progressive supranuclear palsy) and in a variety of subcortical vascular, infectious, inflammatory, neoplastic, and traumatic conditions. The principal features of subcortical dementia include bradyphrenia, impairment of executive function, recall abnormalities, visuospatial disturbances, depression, and apathy. The syndrome contrasts with dementia of the Alzheimer type in which cortical involvement produces aphasia, combined recall and recognition deficits, and indifference. Electrophysiologic, biochemical, and metabolic studies support a distinction between subcortical and cortical dementias.
GASTRIC CANCER: QUO VADIMUS?
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A prospective study of aspirin use and primary prevention of cardiovascular disease in women
Authors: J. E. Manson
Journal: JAMA (1991)

<h3>Objective.</h3> —The aim of the study was to examine prospectively the association between regular aspirin use and the risk of a first myocardial infarction and other cardiovascular events in women. <h3>Design.</h3> —Prospective cohort study including 6 years of follow-up. Setting.—Registered nurses residing in 11 US states. <h3>Participants.</h3> —US registered nurses (n = 87 678) aged 34 to 65 years and free of diagnosed coronary heart disease, stroke, and cancer at baseline. Follow-up was 96.7% of total potential person-years of follow-up. <h3>Main Outcome Measures.</h3> —Incidence of myocardial infarction, stroke, cardiovascular death, and all important vascular events. <h3>Results.</h3> —During 475 265 person-years of follow-up, we documented 240 nonfatal myocardial infarctions, 146 nonfatal strokes, and 130 deaths due to cardiovascular disease (total, 516 important vascular events). Among women who reported taking one through six aspirin per week, the age-adjusted relative risk (RR) of a first myocardial infarction was 0.68 (95% confidence interval [CI], 0.52 to 0.89; P =.005), as compared with those women who took no aspirin. After simultaneous adjustment for risk factors for coronary disease, the RR was 0.75 (95% CI, 0.58 to 0.99; P =.04). For women aged 50 years and older, the age-adjusted RR was 0.61 (95% CI, 0.45 to 0.84; P =.002) and the multivariate RR was 0.68 (95% CI, 0.50 to 0.93; P =.02). We observed no alteration in the risk of stroke (multivariate RR = 0.99; P =.94). The multivariate RR of cardiovascular death was 0.89 (P =.56) and of important vascular events was 0.85 (P =.12). When examined separately, the results were nearly identical for the subgroups who took one through three and four though six aspirin per week. Among women who took seven or more aspirin per week, there were no apparent reductions in risk. <h3>Conclusions.</h3> —The use of one through six aspirin per week appears to be associated with a reduced risk of a first myocardial infarction among women. A randomized trial in women is necessary, however, to provide conclusive data on the role of aspirin in the primary prevention of cardiovascular disease in women. (<i>JAMA</i>. 1991;266:521-527)
J Laboratory &amp;amp; Clinical Medicine, St. Louis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laval Médical, Quebec
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lactose Intolerance
Authors: Juan-R. Malagelada
Journal: New England Journal of Medicine (1995)

Although abdominal symptoms are quite common, a specific cause is rarely found. Under some circumstances, healthy people perceive abdominal sensations arising from the digestive tract. Although it is unusual to be able to perceive physiologic intestinal motility,1 almost everyone can recognize the somewhat uncomfortable fullness that follows the Christmas meal or the imperious need, often heralded by a crampy discomfort, to expel flatus. Some people consider these sensations normal, whereas others regard them as clinical symptoms. ``Symptom'' surveys conducted among apparently healthy people reveal that unpleasant abdominal sensations are quite common and similar to symptoms reported by patients with previously . . .
Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease
Authors: Derek E. Byers, Jennifer Alexander-Brett, Anand C. Patel, Eugene Agapov, Geoffrey Dang-Vu, Xiaohua Jin, Kangyun Wu, Yingjian You, Yael Alevy, Jean-Philippe Girard, Thaddeus S. Stappenbeck, G. Alexander Patterson, Richard A. Pierce, Steven L. Brody, Michael J. Holtzman
Journal: Journal of Clinical Investigation (2013)
Abstract 188: Regulation Of Acetylation Of Histone Deacetylase 2 By P300/CBP-associated Factor/histone Deacetylase 5 In The Development Of Cardiac Hypertrophy
Authors: Hyun Kook, Gwang Hyeon Eom, Yoon Seok Nam, Nakwon Choe, Hyun- Ki Min
Journal: Circulation Research (2014)

Rationale: Histone deacetylases (HDACs) are closely involved in cardiac reprogramming. Although the functional roles of the class I and class IIa HDACs are well established, the significance of interclass crosstalk in the development of cardiac hypertrophy remains unclear. Objective: Recently, we suggested that casein kinase-2α1-dependent phosphorylation of HDAC2 leads to enzymatic activation, which in turn induces cardiac hypertrophy. Here we report an alternate posttranslational activation mechanism of HDAC2 that involves acetylation of HDAC2 mediated by p300/CBP-associated factor (pCAF)/HDAC5. Methods and Results: Hdac2 was acetylated in response to hypertrophic stresses in both cardiomyocytes and a mouse model. The acetylation was reduced by a histone acetyltransferase inhibitor but was increased by a nonspecific HDAC inhibitor. The enzymatic activity of Hdac2 was positively correlated with its acetylation status. pCAF bound to Hdac2 and induced acetylation. The HDAC2 K75 residue was responsible for hypertrophic stress-induced acetylation. The acetylationresistant Hdac2 K75R showed a significant decrease in phosphorylation on S394, which led to the loss of intrinsic activity. Hdac5, one of class IIa HDACs, directly deacetylated Hdac2. Acetylation of Hdac2 was increased in Hdac5 null mice. When an acetylation-mimicking mutant of Hdac2 was infected into cardiomyocytes, the anti-hypertrophic effect of either nuclear tethering of Hdac5 with leptomycin B or Hdac5 overexpression was reduced. Conclusions: Taken together, our results suggest a novel mechanism by which the balance of HDAC2 acetylation is regulated by pCAF and HDAC5 in the development of cardiac hypertrophy.
Diagnosis of brain death and organ donation
Authors: O. S. Surman
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Medical advances in the 20th century have left a long stretch of road between the hare of scientific technology and the tortoise of social policy. Enter the Council on Ethical and Judicial Affairs of the American Medical Association, which reported in abridged form "Decisions Near the End of Life."<sup>1</sup>The article suffers, as do others of this genre, by making no reference to the pressing need for cadaveric organs and the potential loss of such organs when conditions of brain death are precluded by decisions to curtail life-sustaining treatment. The case is made more poignant in Japan where solid-organ transplantation is unavailable from cadaver donors because brain death is not an accepted concept.<sup>2</sup>Brain death is an established entity in American medicine, but it will be more concept than reality as issues around brain death fail to evolve in our efforts toward compassionate and reasoned
Novel metagenomic signature of fungal mycobiome in NAFLD-cirrhosis with validation in a geographically independent cohort
Authors: Tae Gyu Oh, Susy Kim, Bassirian Shirin, Seema Singh, Richele Bettencourt, Lisa Richards, Annette Atkins, Ruth Yu, Brenner David, Claude Sirlin, Michael Downs, Ronald Evans, Rohit Loomba
Journal: Journal of Hepatology (2020)
Letters to the editor
Authors: R R Babb
Journal: Gut (1994)

<h3>Abstract</h3> Achilles tendinopathy affects many running athletes and often leads to chronic pain and functional deficits. While changes in tendon structure have been linked with tendinopathy, the effects of distance running on tendon structure is not well understood. Therefore, the purpose of this study was to characterize structural differences in the Achilles tendons in healthy young adults and competitive distance runners using quantitative ultrasound analyses. We hypothesized that competitive distance runners with no clinical signs or symptoms of tendinopathy would have quantitative signs of tendon damage, characterized by decreased collagen alignment and echogenicity, in addition to previous reports of thicker tendons. Longitudinal ultrasound images of the right Achilles tendon mid-substance were acquired in competitive distance runners and recreationally-active adults. Collagen organization, mean echogenicity, and tendon thickness were quantified using image processing techniques. Clinical assessments confirmed that runners had no signs or symptoms of tendinopathy and controls were only included if they had no history of Achilles tendon pain or injuries. Runner tendons were 40% less organized, 48% thicker, and 41% less echogenic compared to the control tendons (p &lt; 0.001). Young adults engaged in competitive distance-running have structurally different tendons than recreationally-active young adults. While these structural differences have been associated with tendon damage, the lack of clinical symptoms of tendinopathy may suggest that these detected differences may either be precursors of tendinopathy development or protective adaptations to cyclic tendon loading experienced during running.
High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease
Authors: F Tanaka, Y Shiratori, O Yokosuka, F Imazeki, Y Tsukada, M Omata
Journal: Hepatology (1996)

In an attempt to clarify the genetic factors in alcoholism among the Japanese, polymorphism of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes has been investigated. Genetic polymorphism of ADH2/ALDH2 in 66 cases of normal subjects, 90 cases of alcohol dependent, and 31 patients with alcoholic liver disease among Japanese has been analyzed using a polymerase chain reaction assay followed by a direct sequencing method, because ethanol is mainly catabolized by ADH and ALDH and less by cytochrome P450IIE1 and catalase. The incidence of both ADH2*1/*1 and ALDH2*1/*1 was significantly higher in patients with alcohol dependence and in patients with alcoholic liver disease when compared with that in control subjects. In addition, the incidence of ALDH2*1/*2 and ALDH2*2/*2 was significantly reduced in alcoholics compared with control subjects. Genetic polymorphism of ADH2/ALDH2 in patients with alcoholic liver disease was not different from that of alcohol dependents. According to these results, not only ALDH2 gene, often claimed to be responsible for alcohol dependence among Japanese, but also ADH2 gene polymorphism, which modulates the metabolism of ethanol, play important roles in habitual alcohol intake behavior in Japanese patients and in some patients leads to alcoholic liver diseases.
Coloured inhalers.
Authors: M. Partridge
Journal: BMJ (1992)

Suissa and colleagues raise three issues.Firstly, they suggest that the relative risk of 2-0 for fenoterol explains only a small proportion of the epidemic.Our study was based on prescribed drug treatment rather than that actually taken'; this non-differential information bias would tend to decrease the observed odds ratios towards 1.0.2Secondly, they suggest that the epidemic could have been due to overuse of all inhaled B agonists.A similar error was recently made by Staudinger and Haas.'In fact, sales of all B agonists in New Zealand increased considerably only after 1979, three years after the onset of the epidemic,4 in response to suggestions that B agonists should be used regularly rather than on demand.The large relative risks for all B agonists in the Saskatchewan study emerged only in the questionable multi- variate analysis,5 and probably tell us more about overuse of multivariate analysis than overuse of B agonists.