tbuckley/cabot-search huggingface dataset:
Music Lessons
Authors: Ayodele Odutayo, Rashida Williams
Journal: Annals of Internal Medicine (2011)

Letters2 August 2011Music LessonsAyodele Odutayo, BHSc and Rashida Williams, HBScAyodele Odutayo, BHScFrom University of Toronto, Toronto, Ontario, Canada M5S 1A1.Search for more papers by this author and Rashida Williams, HBScFrom University of Toronto, Toronto, Ontario, Canada M5S 1A1.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-3-201108020-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Davidoff's article (1) immediately struck a chord with us and piqued our interest. As long-time musicians, we could not help but to reflect on how music was already making a difference in our careers as students.For the past 9 years, we have proudly participated in a local steel pan orchestra. Although many may recall steel pan music from a recent Caribbean vacation, playing the steel pan is a unique musical experience. The performance usually occurs without the direction of a conductor and without the aid of sheet music. This setting therefore adds a new twist to ...Reference1. Davidoff F. Music lessons: what musicians can teach doctors (and other health professionals). Ann Intern Med. 2011;154:426-9. [PMID: 21403078] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Toronto, Toronto, Ontario, Canada M5S 1A1.Note: This letter is dedicated to the memory of Elton “Smokey” John, founder and leader of the Mississauga Academy of Steelband Music.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMusic Lessons: What Musicians Can Teach Doctors (and Other Health Professionals) Frank Davidoff Music Lessons Justine V. Cohen Metrics 2 August 2011Volume 155, Issue 3Page: 207KeywordsConflicts of interestForecastingHealth careMemory ePublished: 2 August 2011 Issue Published: 2 August 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Development of HPLC Methods for the Purification and Analysis of Plasma Membrane Glycoproteins
Authors: Doris Renauer, H. Uwe Gierlich, Klaus K. Unger
Journal: Environmental Health Perspectives (1990)

High resolution HPLC techniques such as affinity chromatography (AC), ion exchange chromatography (IEC), and size exclusion chromatography (SEC) were used successfully for separations of hydrophobic plasma membrane glycoproteins. We have tested a lot of commercially available columns for IEC and SEC and performed the purification of the crude plasma membrane extract with the most suitable columns. By using immobilized ligands with different specificities and sequential affinity chromatography, it is possible to obtain a preliminary structural characterization of the interesting carbohydrate residues of membrane glycoproteins.
Balloon Radioautography `Disappoints' In Identification of Malignant Gastric Lesions
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The FeNa Test
Authors: Carlos Hugo Espinel
Journal: JAMA (1976)

The Fe<sub>Na</sub>test, a determination of the excreted fraction of the filtered sodium, was performed in patients in the oliguric phase of acute renal failure. Patients with prerenal azotemia had an Fe<sub>Na</sub>of less than 1, and patients with acute tubular necrosis had an Fe<sub>Na</sub>of more than 3 (<i>P</i>&lt;.001). This simple test clearly differentiates between these two conditions and, thus, is of considerable clinical value. (<i>JAMA</i>236:579-581, 1976)
Calreticulin Biosynthesis and Processing in Human Myeloid Cells: Demonstration of Signal Peptide Cleavage and N-Glycosylation
Authors: Gerene M. Denning, Kevin G. Leidal, Valerie A. Holst, Shankar S. Iyer, Doran W. Pearson, Joshua R. Clark, William M. Nauseef, Robert A. Clark
Journal: Blood (1997)

Calreticulin is a soluble endoplasmic reticulum protein comprising the major storage reservoir for inositol trisphosphate-releasable calcium. Although its highly conserved primary structure and a wide range of functions have been well described, less attention has been paid to its biosynthesis, particularly in human tissues. We report analyses of synthesis, proteolytic processing and glycosylation of human calreticulin. In both HL-60 and PLB-985 myeloid cell lines calreticulin was immunoprecipitated as a single 60-kD species without evidence of precursor forms. However, in vitro cell-free synthesis produced a 62-kD primary translation product, which in the presence of microsomal membranes, was processed by cotranslational signal peptide cleavage to a 60-kD species that comigrated with mature calreticulin produced in myeloid cells. Neither tunicamycin treatment of the cells nor endoglycosidase digestion of calreticulin resulted in any forms other than the 60-kD protein on sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis, suggesting that the potential site for N-glycosylation at asparagine-327 was unmodified. However, oxidative derivatization of carbohydrate components with digoxigenin showed that human calreticulin produced in either HL-60 cells or Sf9 insect cells is glycosylated, indicating that glycosylated and nonglycosylated human calreticulin have indistinguishable electrophoretic mobilities. Direct measurement by phenol-H2SO4 confirmed the presence of carbohydrate on recombinant human calreticulin. These data show that human myeloid calreticulin undergoes cotranslational signal peptide cleavage and posttranslational N-linked glycosylation. Although glycosylation of calreticulin has been shown in rat liver and bovine liver and brain, it has been reported to be lacking in other tissues including human lymphocytes.
Preventing Opportunistic Infections in HIV-Infected Injection Drug Users-Reply
Authors: Jonathan E. Kaplan
Journal: JAMA (1997)

We thank Dr Perlman and associates for highlighting the risks of infectious diseases among HIV-infected injection drug users, a population that accounts for a substantial proportion of new HIV infections in the United States each year. Their letter raises 2 issues pertinent to the USPHS/ IDSA guidelines for prevention of opportunistic infections in persons infected with HIV. The first concerns the focus of the guidelines. We have defined opportunistic infections as infections that occur with increased frequency, severity, or both in HIV-infected persons, presumably because of immunosuppression.<sup>1</sup>Given the broad nature of issues related to the care of HIV-infected persons, we limited the scope of the guidelines in both 1995<sup>2</sup>and 1997<sup>3</sup>to the opportunistic infections of greatest importance in HIV-infected persons. This focus is apparent in the opportunistic infections addressed in the disease-specific recommendations as well as in the sections in both documents entitled "Prevention of
Pseudotumor cerebri syndrome in systemic lupus erythematosus
Authors: T. J. Carlow
Journal: JAMA (1974)

A 21-year-old woman had pseudotumor cerebri as a major manifestation of systemic lupus erythematosus. Recognition of this rare association precluded the performance of hazardous neuroradiologic procedures. Treatment with systemic steroids produced a dramatic resolution of all symptoms and signs, including the papilledema. (<i>JAMA</i>228:197-200, 1974)
Swallowing Disorders
Authors: Angela Merlo, Sidney Cohen
Journal: Annual Review of Medicine (1988)

Swallowing is a coordinated activity that enables solids and liquids to pass uninterruptedly from the mouth to the stomach. Dysphagia occurs when this process is disrupted by organic or functional alterations at the level of swallow initiation or esophageal emptying. The differential diagnosis includes obstructive lesions and motility disorders. Symptoms and clinical features help distinguish these diseases.
Outlines for Case Taking and Routine Ward and Laboratory Work, as Used in the Medical Clinic of the Washington University.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sixth UICC International Training Course in Experimental Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Sixth UICC International Training Course in Experimental Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 3, March 1979, Page 712, https://doi.org/10.1093/jnci/62.3.712-c Published: 01 March 1979
Height and mortality from cancer among men: prospective observational study
Journal: BMJ (2005)

encouraged to exercise choice and consumer power by moving between these integrated care organisations, rather than through their choice of secondary or tertiary care providers.To prevent superpractices creaming off low risk, low cost patients, the NHS would need to develop a more sophisticated risk adjusted resource allocation formula.This could use the data now routinely collected at practice level by the new quality outcomes framework-for example, smoking status, body mass index, and blood pressure.National bodies will still be required to assess performance and conduct other monitoring, and both national and regional bodies would provide the technical and infrastructure support for assessing needs and setting priorities.Methods and criteria for managing scarcity and improving services could also be developed at this level but adapted locally with community and partnership agencies.
PREMATURE OBITUARY
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Circulation</i> : Clinical Summaries
Journal: Circulation (2015)

Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events-TIMI 50 TrialVorapaxar is a first-in-class inhibitor of the platelet proteaseactivated receptor-1 pathway that is activated by thrombin.Vorapaxar is established to be effective for the secondary prevention of atherothrombosis and, like other potent antiplatelet agents, increases bleeding.The findings from this analysis of the TRA2°P-TIMI 50 show that, in high-risk patients with diabetes mellitus, the addition of vorapaxar to standard therapy significantly reduced the risk of cardiovascular death, myocardial infarction, or stroke with a favorable effect on net clinical outcomes.Although the relative benefit of vorapaxar was similar in patients with or without diabetes mellitus, there was a greater absolute risk reduction in cardiovascular events with vorapaxar in patients with diabetes mellitus such that only 29 patients needed to be treated to prevent one occurrence of cardiovascular death, myocardial infarction, or stroke over the period of follow-up (3 years).The use of vorapaxar in clinical practice should weigh the potential reductions in ischemic events with the concomitant risk of bleeding.These findings indicate that patients with diabetes mellitus have a particularly favorable balance between the risk of bleeding and reduction in thrombotic events with vorapaxar.See p 1047.
February Sunrise
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Mortality Risk Among Offspring of Psychiatric Inpatients: A Population-Based Follow-Up to Early Adulthood
Authors: Roger T. Webb, Kathryn M. Abel, Andrew R. Pickles, Louis Appleby, Sarah A. King-Hele, Preben B. Mortensen
Journal: American Journal of Psychiatry (2006)

Objective: The purpose of this article was to estimate relative risks of all-cause mortality associated with parental psychiatric disorder based on offspring age (up to 25 years of age), parental diagnosis, maternal versus paternal disorder, and number of affected parents. Method: The study group consisted of all Danish singleton live and stillbirths (N=1.46 million) during 1973-1998, identified using the Central Population Register and Medical Birth Register. Dates of death were recorded with follow-up to Jan. 1, 1999. Parental admission histories since 1969 were obtained from the Psychiatric Central Register. Results: Mortality risks were elevated from birth through early adulthood among offspring of people admitted with any type of psychopathology, although relative risks were attenuated during school attendance years. Effect sizes varied according to offspring ages, the highest being during infancy. The following high-risk subgroups were identified: postneonates with two mentally ill parents, neonates and postneonates whose mothers had alcohol and drug-related disorders, and neonates whose mothers had affective disorders. In general, from the postneonatal period onward, there was no indication that maternal psychopathology is associated with higher offspring mortality risk than paternal disorder. Conclusions: The greatest number of excess deaths were attributable to alcohol-related disorders, this being the most prevalent paternal diagnostic category and the second most prevalent in mothers. Some findings were unexpected. For example, there was no evidence that mortality risk among offspring of parents with schizophrenia and related disorders was significantly greater than that associated with all other parental psychiatric conditions, whereas the relative risk for neonatal death associated with maternal affective disorders was markedly raised.
THE PREVENTION OF BLINDNESS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sites of rhinovirus recovery after point inoculation of the upper airway
Authors: B. Winther
Journal: JAMA (1986)

Spread of rhinovirus infection in the nose was studied after point inoculation of 25 μL of rhinovirus suspension either under the right inferior turbinate via the test duct (26 volunteers) or onto the posterior nasopharyngeal wall (through the mouth under direct vision) (six volunteers). Epithelial brush samples obtained daily from the anterior and posterior portions of the inferior turbinate in both nasal cavities and the nasopharynx were cultured for rhinovirus. Point inoculation of rhinovirus produced a high infection rate, but the entire nasal lining was not infected at the time of peak symptoms. Virus was usually first detected at the nasopharyngeal site, with subsequent spread of infection anteriorly to one or both inferior turbinates. Spread to the left turbinate was not detected in seven of 17 volunteers during the first five days after right eye inoculation. Virus recovery from the mucosa declined by day 16 and ceased by day 21. (<i>JAMA</i>1986;256:1763-1767)
Hysterical Amblyopia in Children
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1568: Loss of Ischemic Postconditioning in the Mouse Hearts Lacking Adenosine A <sub>1</sub> or Bradykinin B <sub>2</sub> Receptors
Authors: Lei Xi, Anindita Das, Zhi-Qing Zhao, Vanessa F Merino, Michael Bader, Rakesh C Kukreja
Journal: Circulation (2007)

Background: Ischemic postconditioning (PostC) is a recently described cardioprotective modality against reperfusion injury, through a series of brief episodes of reperfusion/ischemia at the very onset of reperfusion. It has been well recognized that PostC can activate cellular signaling cascade, in which the role of G protein-coupled membrane receptors serving as upstream triggers of PostC remains to be established. Hence the goal of this study was to determine a definitive role of adenosine A 1 receptors (A1) and bradykinin B 1 or B 2 receptors (B1 or B2) in PostC, using gene knockout (KO) mice. Methods &amp; Results: The hearts isolated from adult male C57BL/6J wild-type mice (C57-WT) or A1, B1, or B2 KO mice (n=7–9 per group) were subjected to 20 min of zero-flow global ischemia and 30 min of reperfusion with or without PostC in a Langendorff isolated, buffer-perfused heart model. PostC, consisted of 6 cycles of 10 sec of reperfusion and 10 sec of ischemia, significantly reduced myocardial infarct size (22.8±3.1%, Mean±SEM) as compared with C57-WT controls (35.1±2.8%, P&lt;0.05). As shown in Figure below, the infarct-limiting protection of PostC was absent in A1-KO (34.9±2.7%) or B2-KO (33.3±1.7%) and was partially attenuated in B1-KO (25.6±2.9%) mice, as compared with the corresponding non-PostC controls under same genetic background (P&gt;0.05). However, cardiac contractile function and coronary flow at the end of reperfusion were not significantly altered by PostC. Conclusion: PostC-induced infarct size reduction in globally ischemic mouse hearts is triggered by activation of multiple G protein-coupled membrane receptors, which include A1, B2, and, to a lesser extent, B1 receptors.