tbuckley/cabot-search huggingface dataset:
Pure red cell aplasia with thymoma: Evidence of T‐cell clonal disorder
Authors: Michihiko Masuda, Yukari Arai, Takamitsu Okamura, Hideaki Mizoguchi
Journal: American Journal of Hematology (1997)

Pure red cell aplasia (PRCA) sometimes accompanies thymoma. Herein, we report a PRCA patient with thymoma with a clonal disorder of T cells. A 55-year-old man presented with anemia and anterior mediastinum tumor. The laboratory study revealed hemoglobin 8.2 g/dl; leukocytes 15.8 × 109/L with 76.5% neutrophils, 20.0% lymphocytes, and reticulocytes 0.0%. Bone marrow aspirate smears and biopsy sections revealed normal myeloid and megakaryocyte differentiation and contained no erythroid precursors. We made the diagnosis of PRCA. The size of the lymphocytes was small without any granules in the cytoplasm. The surface marker of peripheral blood mononuclear cells demonstrated increased CD2+, CD3+, CD4−, and CD8+ populations. The mediastinal tumor was resected and a thymoma diagnosed. A monoclonal rearrangement of T-cell receptor (TCR)- β-chain gene was found using Southern blot analysis of the mononuclear cells in both peripheral blood and thymoma. Treatment with prednisolone, thymectomy, and cyclophosphamide exerted no beneficial effect. After initiation of the Cyclosporin A therapy, the patient developed reticulocytosis. This PRCA case seems to present a neoplastic proliferation of CD8+ T cells in peripheral blood and thymus with a monoclonal rearrangement of the TCR- β-chain gene. Am. J. Hematol. 54:324–328, 1997. © 1997 Wiley-Liss, Inc.
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
Authors: Jan Lammerding, P. Christian Schulze, Tomosaburo Takahashi, Serguei Kozlov, Teresa Sullivan, Roger D. Kamm, Colin L. Stewart, Richard T. Lee
Journal: Journal of Clinical Investigation (2004)

Mutations in the lamin A/C gene (LMNA) cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. The tissue-specific effects of lamin mutations are unclear, in part because the function of lamin A/C is incompletely defined, but the many muscle-specific phenotypes suggest that defective lamin A/C could increase cellular mechanical sensitivity. To investigate the role of lamin A/C in mechanotransduction, we subjected lamin A/C–deficient mouse embryo fibroblasts to mechanical strain and measured nuclear mechanical properties and strain-induced signaling. We found that Lmna–/– cells have increased nuclear deformation, defective mechanotransduction, and impaired viability under mechanical strain. NF-κB–regulated transcription in response to mechanical or cytokine stimulation was attenuated in Lmna–/– cells despite increased transcription factor binding. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription. These findings suggest that the tissue-specific effects of lamin A/C mutations observed in the laminopathies may arise from varying degrees of impaired nuclear mechanics and transcriptional activation.
ECTAS: A phase II study of TAS-102 for advanced/recurrent esophageal cancer refractory/intolerable to standard therapies
Authors: Takahiro Tsushima, Hiroi Kasai, Takashi Kojima, Hiroki Hara, Yukiko Mori, Ryu Ishihara, Ken Kato, Shuichi Hironaka, Harue Tada, Manabu Muto
Journal: Annals of Oncology (2017)
Pacemaker Support
Authors: Nicholas M. Azzato
Journal: JAMA (1972)

<h3>To the Editor.—</h3> On reading the LETTER by Ali on external support for pacemaker pulse generator it seemed to me that the external support is not necessary. I have been called in consultation for patients with extrused implants. When the implant was replaced, a piece of background of polyester fiber suture (Mersilene) fabric strip was glued to the external surface of the pacemaker and sutured through the adjacent fat and musculature to provide external support for the weight of the pacemaker. This provides adequate support in the patient internally and eliminates the need for any external support in those patients in whom extrusions might be a problem.
Die Syphilis des Zentralnervensystems: ihre Ursachen und Behandlung.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preferential DNA Repair in Expressed Genes
Authors: Philip C. Hanawalt
Journal: Environmental Health Perspectives (1987)

Potentially deleterious alterations to DNA occur nonrandomly within the mammalian genome. These alterations include the adducts produced by many chemical carcinogens, but not the UV-induced cyclobutane pyrimidine dimer, which may be an exception. Recent studies in our laboratory have shown that the excision repair of pyrimidine dimers and certain other lesions is nonrandom in the mammalian genome, exhibiting a distinct preference for actively transcribed DNA sequences. An important consequence of this fact is that mutagenesis and carcinogenesis may be determined in part by the activities of the relevant genes. Repair may also be processive, and a model is proposed in which excision repair is coupled to transcription at the nuclear matrix. Similar but freely diffusing repair complexes may account for the lower overall repair efficiencies in the silent domains of the genome. Risk assessment in relation to chemical carcinogenesis requires assays that determine effective levels of DNA damage for producing malignancy. The existence of nonrandom repair in the genome casts into doubt the reliability of overall indicators of DNA binding and lesion repair for such determinations. Furthermore, some apparent differences between the intragenomic repair heterogeneity in rodent cells and that in human cells mandate a reevaluation of rodent test systems for human risk assessment. Tissue-specific and cell-specific differences in the coordinate regulation of gene expression and DNA repair may account for corresponding differences in the carcinogenic response.
Medical school, residency, and eventual practice location. Toward a rationale for state support of medical education
Authors: H. R. Mason
Journal: JAMA (1975)

Because of the shrinking charity dollar, a growing number of state governments are being asked to provide financial support to private medical schools. Such expenditures are more likely to appeal to legislators and to benefit medicine in the state if they can be related to existing manpower deficits. (<i>JAMA</i>233:49-52, 1975)
Sudden infant death and old adrenal hemorrhage
Authors: S. H. Tsung
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short Notes of the Opinions and Practice of the Late John Pearson, Esq., F.R.S., on Syphilitic Disease
Authors: W. S. Oke
Journal: BMJ (1848)

would involve the employmenut of every remedy calcu- lated to favour our object, and assist nature in the accomplishment of her views, and assuredly this would be to interfere with the natural history of disease.It is not easy to bring this question to the test of experience, for in the first place men judge very differ.ently as to the form and degree of malady; they arrive at very different opinions of the self-same disorders;
Cultured Heart Cell Reaggregate Model for Studying Cardiac Toxicology
Authors: Nick Sperelakis
Journal: Environmental Health Perspectives (1978)

This review represents a summary of the technique of using cultured heart cells as a model system for studying the physiology, pharmacology, biochemistry and toxicology of myocardial cells. The general techniques and types of culture preparations commonly used are given and some of the advantages and disadvantages of working with cultured heart cells are summarized.
VACANCIES IN THE ARMY MEDICAL CORPS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Elimination of large tumors in mice by mRNA-encoded bispecific antibodies
Authors: Christiane R Stadler, Hayat Bähr-Mahmud, Leyla Celik, Bernhard Hebich, Alexandra S Roth, René P Roth, Katalin Karikó, Özlem Türeci, Ugur Sahin
Journal: Nature Medicine (2017)
Colonoscopy
Authors: Thomas D. Crowson
Journal: JAMA (1976)

CANCER of the large intestine frequently develops in patients who have had ulcerative colitis for more than ten years. When ulcerative colitis begins in childhood and involves the entire colon, the incidence of colonic cancer after the first ten years is reported to be 20% per decade. With the advent of colonoscopy, it is now suggested that multiple, periodic, colonoscopic biopsies with tissue taken from throughout the colon can detect the early development of cancer<sup>1,2</sup>in patients with chronic ulcerative colitis. The following case report shows that colonoscopy, even in the hands of an excellent endoscopist, cannot always be relied on in the diagnosis of carcinoma. <h3>Report of a Case</h3> A 34-year-old man was first seen at the Ochsner Clinic in 1972. In 1963 a chronic diarrhea that he had had since 1962 had been diagnosed elsewhere as ulcerative colitis. The colitis had been well controlled with salicylazosulfapyridine (Azulfidine);
SILICA IN TUBERCULOSIS
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal Angiography
Authors: Eugene F. Poutasse
Journal: JAMA (1966)

This comprehensive monograph on renal angiography has value for urologists, vascular surgeons, radiologists, and all clinicians interested in renal disease. Virtually everything pertaining to the subject is covered in this 12-chapter collaborative volume. The first four chapters provide basic information on renal angiography: "Embryologic and Anatomic Considerations" ( W. H. Hollinshead); "Technics and Hazards of Renal Angiography" (O. W. Kincaid); "Normal Renal Angiogram" (O. W. Kincaid); and "Variations in Renal Blood Supply" (G. D. Davis). The fifth chapter, written by J. G. Hunt, concisely reports the clinical and physiological aspects of renovascular hypertension and the selection of patients for renal angiography. Next is a beautifully illustrated chapter, also by Kincaid, on intrinsic and extrinsic diseases of the renal artery. It covers the subject completely, but unfortunately the scope of the book did not permit more on postoperative angiograms, to show correction of some of these interesting diseases. The seventh chapter, "Renal
BOOK REVIEWS
Journal: Circulation (1973)

The purpose of this publication is to provide the reader with an understanding of the anatomy, function and control mechanisms of the arterial and venous circulations of the lower extremity of man.The book contains three sections of two to four chapters.Numerous illustrations (tables, graphs, charts, etc.) complement the text.Thirty-one color plates, most of them of plastic casts of portions of the circulatory tree,
Adequacy of dialysis and nutrition in continuous peritoneal dialysis
Journal: Journal of the American Society of Nephrology (1996)

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THE METABOLISM OF FEVER.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Police Detainment of a Patient Following Treatment With Radioactive Iodine
Authors: C. Buettner
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
National Conference on the Lymphomas and the Leukemias
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article National Conference on the Lymphomas and the Leukemias Get access JNCI: Journal of the National Cancer Institute, Volume 58, Issue 4, April 1977, Page 1177, https://doi.org/10.1093/jnci/58.4.1177-c Published: 01 April 1977
Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers
Authors: Maryline Mancini-Bourgine, Hélène Fontaine, Daniel Scott-Algara, Stanislas Pol, Christian Bréchot, Marie-Louise Michel
Journal: Hepatology (2004)

Despite the availability of effective hepatitis B vaccines for many years, over 370 million people remain persistently infected with hepatitis B virus (HBV). Viral persistence is thought to be related to poor HBV-specific T-cell responses. A phase I clinical trial was performed in chronic HBV carriers to investigate whether HBV DNA vaccination could restore T-cell responsiveness. Ten patients with chronic active hepatitis B nonresponder to approved treatments for HBV infection were given 4 intramuscular injections of 1 mg of a DNA vaccine encoding HBV envelope proteins. HBV-specific T-cell responses were assessed by proliferation, ELISpot assays, and tetramer staining. Secondary end points included safety and the monitoring of HBV viraemia and serological markers. Proliferative responses to hepatitis B surface antigen were detected in two patients after DNA injections. Few HBV-specific interferon γ–secreting T cells were detectable before immunization, but the frequency of such responses was significantly increased by 3 DNA injections. Immunization was well tolerated. Serum HBV DNA levels decreased in 5 patients after 3 vaccine injections, and complete clearance was observed in 1 patient. In conclusion, this study provides evidence that HBV DNA vaccination is safe and immunologically effective. We demonstrate that DNA vaccination can specifically but transiently activate T-cell responses in some chronic HBV carriers who do not respond to current antiviral therapies. Supplementary material for this article can be found on the HEPATOLOGYwebsite (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html). (HEPATOLOGY 2004;40:874–882.)
Accidental Vaccination.
Authors: G. D. Lind
Journal: JAMA (1901)

Meadow Creek, W. Va., Feb. 21, 1901. <h3>To the Editor:</h3> —In the February number of<i>Medicine</i>, a case of vaccin infection was reported. I have seen a similar case. Some time last November a woman came to my office to show me a peculiar looking sore on her neck. I had recently vaccinated a number of persons, and, among them, three children in the family in which this woman was a nurse. On inquiry I found she had been scratched on the neck by one of the children, while taking care of it. She had never been vaccinated. The sore was a characteristic vaccination pustule. I was forced to the conclusion that the child had accidentally conveyed the vaccin from its arm to the neck of the nurse by its finger nails.
Empire Rheumatism Council: Nineteenth Annual Report, 1955
Authors: W Copeman, H The Duke, Miss Muir, G Pickering
Journal: Annals of the Rheumatic Diseases (1956)

of Gloucester, President of the Council, was in the Chair.17-hydroxycorticosteroids retain their 17-ketogenic property and 17-ketones are unaffected.This selective elimination of 17: 21-dihydroxy-20-oxosteroids as potential precursors of 17-oxosteroids can be brought about in the urine and hence a simple means becomes available for the differential analysis of urinary 17-ketogenic steroids.
What if Americans ate less fat?
Authors: R. C. Gantt
Journal: JAMA (1992)

<h3>In Reply.</h3> —We thank the correspondents for their interest in our work, which estimated that if all Americans followed a 30% energy as fat diet, about 42000 deaths would be delayed annually, adding 3 to 4 months to average life expectancy, mostly after age 75 years. We agree with Dr Bailar that there is uncertainty in our results. Nonetheless, they are the best estimates we could make from available data. We would ask: If not enough is known to estimate the likely impact of US health policy about dietary fat, how confident should we be in that policy? Ms Shepard and Dr Prentice raise the issue of regression-dilution bias. However, to the degree that a single measurement of a risk factor underestimates the true RR, it also overestimates the spread of the true distribution of the risk factor. Thus, it is not appropriate to inflate the RRs—as they have apparently