tbuckley/cabot-search huggingface dataset:
OVERDONE STERILIZATION.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Negligible synergistic effect of β2‐glycoprotein I on the reactivity of antioxidized low‐density lipoprotein antibody to oxidized low‐density lipoprotein
Authors: Juzo Matsuda, Moritaka Gotoh, Kazuo Kawasugi, Kengo Gohchi, Miyo Tsukamoto, Noriko Saitoh
Journal: American Journal of Hematology (1996)

We conducted this study to investigate whether antioxidized low-density lipoprotein (a-oxLDL) is an antibody to cryptic and/or neo-antigen on β2-glycoprotein I (GPI), which is introduced by binding to anionic phospholipid, similar to that of GPI-dependent anticardiolipin antibody (aCL) employing a-oxLDL ELISA. We found that no significant optical density differences existed among systemic lupus erythematosus patients, including cases with aCL and/or lupus anticoagulant positivity, before and after the addition of GPI. Our results suggest that a-oxLDL is not an antibody to denatured GPI, but rather to oxLDL. © 1996 Wiley-Liss, Inc.
Correction: A Prevalent Variant in PPP1R3A Impairs Glycogen Synthesis and Reduces Muscle Glycogen Content in Humans and Mice
Authors: David B Savage, Lanmin Zhai, Balasubramanian Ravikumar, Cheol Soo Choi, Johanna E Snaar, Amanda C McGuire, Sung-Eun Wou, Gemma Medina-Gomez, Sheene Kim, Cheryl B Bock, Dyann M Segvich, Bhavana Solanky, Dinesh Deelchand, Antonio Vidal-Puig, Nicholas J Wareham, Gerald I Shulman, Fredrik Karpe, Roy Taylor, Bartholomew A Pederson, Peter J Roach, Stephen O'Rahilly, Anna A DePaoli-Roach
Journal: PLoS Medicine (2008)
THE EXPERIMENTAL INVESTIGATION OF SENESCENCE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Anatomy and Histology of the Human Eyeball in the Normal State.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma β-Amyloid Level, Cognitive Reserve, and Cognitive Decline
Authors: Nunzio Pomara
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABSTRACTS
Journal: Circulation (1955)

Young male rats fed diets low in choline (level- oped myocardial changes consisting of the ap pearance of fat droplets within the cells and areas of frank necrosis.The cardiac effects were aggravated by administration of a diet of high fat con- tent.The extent of changes in the heart was by no means always parallel to that in the kidney. McKusICK BACTERIAL ENDOCARDITIS
Correction
Journal: The Journal of Experimental Medicine (2000)

The authors wish to report the following two corrections.Most likely because of allelic polymorphism, the KIR2DL4 used here differs by three amino acids from the sequence deposited in EMBL/ GenBank/DDBJ (under accession no.U7119): a valine for the leucine at position 87, a glycine for the glutamate 124, and an asparagine for the histidine 371.Second, the expression system in the cell line NK-92 that was used to test functional recognition of HLA-G by KIR2DL4 has been unreliable.Additional experiments have revealed that the inhibition of lysis of 721.221 cells expressing HLA-G (221-G) occurs sometimes in NK-92 cells infected with recombinant vaccinia viruses that do not encode KIR2DL4.Therefore, the data reporting inhibition in NK-92 cells are inconclusive.Although this correction invalidates several of the results obtained with the NK-92 cell line, the main conclusion of the paper that KIR2DL4 binds HLA-G remains valid.Specific binding of soluble KIR2DL4-Ig fusion protein to 221-G cells has been confirmed.KIR2DL4-Ig bound also to the HLA-G-expressing trophoblast cell line JEG-3.Binding was blocked by an anti-KIR2DL4 mAb, and was inhibited partially by the HLA-G-specific mAb G233.
Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep Layers of the Medial Entorhinal Cortex
Authors: Gülşen Sürmeli, Daniel Cosmin Marcu, Christina McClure, Derek L.F. Garden, Hugh Pastoll, Matthew F. Nolan
Journal: Neuron (2016)

(Neuron 88, 1040–1053; December 2, 2015) In the original article, the title of Figure 6 was written as “Hippocampal Outputs Preferentially Target Neurons in L5a.” The correct title should be “Hippocampal Outputs Preferentially Target Neurons in L5b.” This has been corrected online. The authors regret the error. Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep Layers of the Medial Entorhinal CortexSürmeli et al.NeuronNovember 19, 2015In BriefSürmeli et al. demonstrate that input and output functions of the deep layers of the medial entorhinal cortex are divided between two cell populations that are distinguished by their molecular identity, lamina position, translaminar and hippocampal inputs, and telencephalic targets. Full-Text PDF Open Access
Health care in the USA: turning the corner
Authors: None The Lancet
Journal: The Lancet (2014)

The Affordable Care Act (ACA)—the federal statute enacted to increase the number of Americans with health insurance—has reached an important milestone in the journey towards universal health coverage as the major components of the law came into effect in January, 2014. As part of the multiphase implementation of the ACA, the new year brought several key changes, including a ban on insurance companies from denying coverage on the basis of pre-existing medical conditions and terminating coverage if a policy holder becomes ill.
THE WAR SESSION OF THE ASSOCIATION IN CHICAGO
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assistants in General Practice
Journal: BMJ (1950)

seems to deserve a trial.One difficulty in promoting a controlled community study is that croup is usually worse at night yet, as Doull states, 'it is essential that the child is reassessed two to four hours after treatment'.'This may not be so difficult for on-call cooperatives or deputizing services, but their doctors might be less reliable in the recruitment of patients.The GP on call for his own patients may be more motivated about the trial, but might choose to admit a child to hospital in order to protect his own sleep.
Laryngeal Epilepsy
Authors: W. R. Parkes
Journal: BMJ (1951)

TCRs recognize peptides on MHC molecules and induce downstream signaling, leading to activation and clonal expansion. In addition to the strength of the interaction of TCRs with peptides on MHC molecules, mechanical forces contribute to optimal T cell activation, as reflected by the superior efficiency of immobilized TCR–cross-linking Abs compared with soluble Abs in TCR triggering, although a dedicated mechanotransduction module is not identified. We found that the professional mechanosensor protein Piezo1 is critically involved in human T cell activation. Although a deficiency in Piezo1 attenuates downstream events on ex vivo TCR triggering, a Piezo1 agonist can obviate the need to immobilize TCR–cross-linking Abs. Piezo1-driven Ca<sup>2+</sup> influx, leading to calpain activation and organization of cortical actin scaffold, links this mechanosensor to optimal TCR signaling. Thus, we discovered a hitherto unknown regulatory mechanism for human T cell activation and provide the first evidence, to our knowledge, for the involvement of Piezo1 mechanosensors in immune regulation.
Potential for Bias in Epidemiologic Studies That Rely on Glass-Based Retrospective Assessment of Radon
Authors: C. R. Weinberg
Journal: Environmental Health Perspectives (1995)

Retrospective assessment of exposure to radon remains the greatest challenge in epidemiologic efforts to assess lung cancer risk associated with residential exposure. An innovative technique based on measurement of alpha-emitting, long-lived daughters embedded by recoil into household glass may one day provide improved radon dosimetry. Particulate air pollution is known, however, to retard the plate-out of radon daughters. This would be expected to result in a differential effect on dosimetry, where the calibration curve relating the actual historical radon exposure to the remaining alpha-activity in the glass would be different in historically smoky and nonsmoky environments. The resulting "measurement confounding" can distort inferences about the effect of radon and can also produce spurious evidence for synergism between radon exposure and cigarette smoking.
Mutations of Gonadotropins and Gonadotropin Receptors: Elucidating the Physiology and Pathophysiology of Pituitary-Gonadal Function
Authors: A. P. N. Themmen
Journal: Endocrine Reviews (2000)

The recent unraveling of structures of genes for the gonadotropin subunits and gonadotropin receptors has provided reproductive endocrinologists with new tools to study normal and pathological functions of the hypothalamic-pituitary-gonadal axis. Rare inactivating mutations that produce distinctive phenotypes of isolated LH or FSH deficiency have been discovered in gonadotropin subunit genes. In addition, there is a common polymorphism in the LHβ subunit gene with possible clinical significance as a contributing factor to pathologies of LH-dependent gonadal functions. Both activating and inactivating mutations have been detected in the gonadotropin receptor genes, a larger number in the LH receptor gene, but so far only a few in the gene for the FSH receptor. These mutations corroborate and extend our knowledge of clinical consequences of gonadotropin resistance and inappropriate gonadotropin action. The information obtained from human mutations has been complemented by animal models with disrupted or inappropriately activated gonadotropin ligand or receptor genes. These clinical and experimental genetic disease models form a powerful tool for exploring the physiology and pathophysiology of gonadotropin function and provide an excellent example of the power of molecular biological approaches in the study of pathogenesis of diseases.
Availability of Flow Cytometric Immunophenotyping of Lymphocytes to Hospital Patients—United States
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIABETES MELLITUS.
Authors: J. M. ALLEN
Journal: JAMA (1899)

Diabetes mellitus is a disease in the beginning of perverted nutrition, caused either by hereditary, functional or organic disease. There is some testimony that it may be communicated from one person to another. It also follows syphilitic lesions near the fourth ventricle of the brain. Later pathologic changes may occur in one or more of the following organs: pancreas, liver, heart, and Kidneys, also in the nerve centers of the cardiac and solar plexus. The perversion consists of the entrance in to the blood of an abnormal quantity of saccharine matter. This saccharine matter practically acts as a strong diuretic by producing hyperemia of the kidneys, which results in increased functional action manifested by the passage of large quantities of urine loaded with saccharine matter depuriated from the blood. While this perverted functional action of the kidneys is largely in excess of normal, it must be considered as a conservative
Child abuse and children's advocates, inc
Authors: H. Tanous
Journal: JAMA (1979)

<h3>To the Editor.—</h3> I am writing regarding the excellent article "Who Needs Counseling in Child Abuse?" by B. J. M. (242:132, 1979). The lack of protection for abused children in the United States is scandalous. They are frequently returned to dangerous environments by governmental agencies, hospitals, or physicians without legal representation, where they are the victims of repeated acts of cruelty. These children are crying out in anguish for help. In the United States there are an estimated 1 million cases of child abuse, and 4,000 deaths occur annually. Many severely abused children suffer permanent physical injury, and of those returned to their environment, at least 10% die. According to a Department of Health, Education, and Welfare official, the plight of the majority of children who die from abusive treatment was previously known to some form of authority before the deaths. A revealing report by Berkeley Planning Associates, funded by
Previous hospital care as a risk factor for pneumonia. Implications for immunization with pneumococcal vaccine
Authors: D. S. Fedson
Journal: JAMA (1982)

In the Oxford Record Linkage Study population in 1970, seven hundred ninety-three persons were hospitalized for or died as a result of pneumonia. Thirty-six percent who survived and 49% who died had been discharged from hospital within the previous five years. For the period 1963 through 1970, cohort analysis determined the probability of subsequent readmission and/or death caused by pneumonia within the next five years for patients discharged with any condition and with high-risk conditions only. From this analysis, it was estimated that pneumococcal immunization of relatively few discharged patients would prevent each subsequent readmission and death from pneumococcal pneumonia. These results suggest that, in addition to age and underlying medical condition, patterns of previous hospital care can be used to identify many persons at increased risk of developing pneumonia. If current patterns of previous hospital care are similar to those found in Oxfordshire, physicians should consider giving pneumococcal vaccine to patients who are discharged from hospitals. (<i>JAMA</i>1982;248:1989-1995)
Abstract 186: Heart Disease Associated Lamin A/C Mutations and Resultant Defects in Cell and Nuclei Structure
Authors: Jason Q Core, Zachery R Robinson, Mehrsa Mehrabi, Linda A McCarthy, Michael V Zaragoza, Anna Grosberg
Journal: Circulation Research (2017)

Changes in cell organelle structure or shape, which can be associated with a variety of diseases, can be caused by inherited genetic mutations. For example, the progeria disease is associated with a mutation to the LMNA gene, and it leads to a devastating early aging and death. However, other LMNA gene mutations do not cause early aging, but instead have a more subtle effect with patients presenting only with heart disease symptoms. One way to study the mechanisms that lead to these differences is in vitro with patient specific cell-lines. Here we will present a study of 10 cell-lines negative for mutations or with four different types of LMNA mutations: 1) Hutchinson-Gilford progeria syndrome LMNA gene mutation, 2) LMNA splice-site mutation (c.357-2A&gt;G , p.N120Lfs*5), 3) LMNA nonsense mutation (c.736 C&gt;T, p.Q246X), and 4) LMNA missense mutation (c.1003C&gt;T, p.R335W) in exon 6. Fibroblasts from each of these cells lines were cultured on either isotropic fibronectin or fibronectin patterned into anisotropic lines. The cells were then fixed and stained to visualize the nuclei, actin fibrils, and the underline remodeled fibronectin. To analyze this data, we applied existing algorithms to quantify the re-organization of actin in response to extracellular matrix cues by calculating both the actin and fibronectin orientational order parameter. Additionally, we have created a new algorithm to automatically identify nuclei defects, which is a known property of the progeria LMNA mutation. Using the new algorithm, it is possible to separately characterize the shape of normal and defective nuclei for each cell-line. Through this algorithm, we show the varied effects of the different mutations on the number of fibroblasts that present with nuclear defects and their properties. The current data is consistent with the known patient symptoms providing further avenues of study into the mechanisms triggered by these mutations. Furthermore, we probe whether the unique mechanical conditions present in the myocardium are responsible for the heart disease symptoms of some of the tested mutations.
Incorrect Sentences.
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal