tbuckley/cabot-search huggingface dataset:
45th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in association with the Council on Nutrition, Physicial Activity and Metabolism
Journal: Circulation (2005)

Primiparity is associated with greater long-term reductions in HDL levels of 3 to 4 mg/dl in adult women independent of weight gain, waist girth and behaviors.Adolescent pregnancy is characterized by a higher fat gain after the first half of gestation and greater postpartum weight retention.It is not known whether pregnancy exacerbates changes in plasma lipids during adolescence.We examined the association of pregnancy with changes in plasma lipids (⌬Lipids) among Black (B) and White (W) girls aged 9 -10 yrs at baseline ( 1987) with annual follow-up visits over 10 yrs (1996) in the multi-center NHLBI Growth and Health Study.Of 2379 girls enrolled, we included 939 (39%) who had fasting plasma lipids, reproductive and anthropometric data available at both baseline and yr 10 exams.Pregnancy groups were: 167 (130 B, 37 W) gave birth 1 or more times (G1ϩP1ϩ), 113 (62 B, 51 W) were pregnant but had no births (G1ϩP0) and 659 (279 B, 380 W) were not pregnant (G0) during 10 yrs.Mean (SE) changes in plasma lipids, BMI (⌬BMI) and waist girth (⌬WST) were calculated by subtracting baseline from yr 10 measurements.Linear regression models were used to evaluate ⌬Lipids by pregnancy group adjusting for baseline measurement, race, income and mother's education.⌬BMI and ⌬WST were added to models.Pregnancy group-association with ⌬Lipids did not vary by race, baseline BMI, age at menarche or other covariates.Greater decrements in HDL were found for G1ϩP1ϩ (-4.6 mg/dl) and G1ϩP0 (-0.9 mg/dl) vs G0.Pregnancy was not associated with ⌬ in other lipids.In both races, greater gains in BMI and waist girth were associated with pregnancy during adolescence, but did not explain the larger decrement in HDL associated with pregnancy or childbearing.Decrement in HDL associated with pregnancy during adolescence is similar to previous findings in adult women independent of weight gain and waist girth.We hypothesize that biologic mechanism(s) of pregnancy are responsible for the decline in maternal HDL levels.
Peliosis hepatis associated with administration of oxymetholone
Authors: E. C. McDonald
Journal: JAMA (1978)

PELIOSIS hepatis is an unusual cystic lesion of the liver that was first recognized as a discrete entity by Schoenlank<sup>1</sup>in 1916. To our knowledge, only three cases have been diagnosed antemortem; in one instance, the lesion regressed following discontinuation of oxymetholone therapy.<sup>2-4</sup> We report the case of a patient with Hodgkin's disease, who was found to have peliosis hepatis after receiving oxymetholone. <h3>Report of a Case</h3> A 21-year-old man was examined in April 1970, with a three-week history of malaise, weight loss, night sweats, hectic fevers, anorexia, and pruritus. The patient was severely ill with cervical adenopathy and splenomegaly. Biopsy of a cervical lymph node showed nodular sclerosing Hodgkin's disease. Baseline liver function tests were normal, and an initial hematocrit level was 31%. Oxymetholone was first used in early November 1974. The patient received 30 mg per day, orally, and was followed up closely to detect any
&lt;TITLE&gt;Lung Disease&lt;/TITLE&gt;
Authors: Brian Pace, Richard Glass, Jeff Molter
Journal: JAMA (2000)

Lung DiseaseThe JAMA Patient Page is a public service of JAMA and the AMA.The information and recommendations appearing on this page are appropriate in most instances, but they are not a substitute for medical diagnosis.For specific information concerning your personal medical condition, JAMA and the AMA suggest that you consult your physician.This page may be reproduced noncommercially by physicians and other health care professionals to share with patients.Any other reproduction is subject to AMA approval.To purchase bulk reprints, call 212/354-0050.reathing is such a vital function that your body does it automatically.Your lungs provide an essential step in a system that delivers a continuous supply of life-giving oxygen to your body.Your lungs also help eliminate carbon dioxide (a waste by-product of energy-producing chemical processes) from your body.An article in the April 12, 2000, issue of JAMA reports on diagnosing chronic obstructive pulmonary disease (COPD), a term used for lung conditions that are characterized by obstruction to the airflow in the respiratory system.If you are experiencing difficulty breathing, you should see your doctor for an evaluation.
Hypertension. I.
Journal: BMJ (1971)

RESULTSThe usual result of modern prostatectomy is a satisfied patient who is able to leave hospital within a week or ten days passing uninfected urine with perfect control and a good stream.He should return to his normal occupation within a further three weeks.He may play golf, do the garden, swim, and make love-though, as to the last, he may be infertile owing to interference with the mechanism of ejaculation, which sometimes occurs after all forms of prostatectomy.Late complications are unusual: in good centres less than one in ten gets a urinary infection, but this may take a month or two to clear up afterwards.Strictures at the neck of the bladder or in the urethra occur after all forms of prostatectomy but for- tunately respond well to a few dilatations.Continuing symp- toms usually mean coexisting disease, or the incomplete removal of adenoma-a complication slightly more common after transurethral than after open operations.Carcinoma of the prostate may occur long after any prostatectomy, since it originates in the outer "surgical capsule" of gland, which is deliberately left behind.For the same reason another benign adenoma can arise from this same shell of tissue but it takes many years.
Prevalence of oligoprogressive, metastatic castration-resistant prostate cancer (mCRPC) amenable to stereotactic ablative radiotherapy (SABR) in men undergoing abiraterone acetate (AA) therapy.
Authors: Erica McDonald, Sierra Cheng, Vanessa Sarah Arciero, Ronak Saluja, Katherine A. Zukotynski, Patrick Cheung, Urban Emmenegger
Journal: Journal of Clinical Oncology (2017)

e16509 Background: SABR is increasingly used for treating men with oligometastatic prostate cancer, a state between loco-regional and widespread metastatic disease that exists de novo, presents as oligorecurrence, is treatment-induced, or occurs as oligoprogression. The latter is a clinical situation where a limited number of metastatic tumor sites progress (usually defined as ≤3-5), while all other metastases are controlled by a given systemic therapy. The frequency of oligoprogression amenable to SABR is unknown. Methods: Thus, in a retrospective chart analysis we studied the progression pattern of 35 men with chemotherapy-naïve mCRPC undergoing AA therapy, and of 20 men undergoing AA therapy after docetaxel chemotherapy. Applying RECIST1.1 and/or PCWG2 criteria, patients (pts) were considered SABR candidates if they radiologically progressed in ≤5 distinct metastatic locations, while all other sites were stable or responding. Results: In chemotherapy-naïve men, pre-AA metastatic lesions were located in bone (94%), lymph nodes (49%), lungs (17%) and liver (3%), whereas progression during AA therapy occurred in bone (89%), lymph nodes (49%), lungs (14%) and liver (9%). 12 pts (34%) met the criteria of oligoprogression with a median of 2 progressive lesions/pt (range 1-5). 8 pts presented with bone progression only, 3 with nodal progression, and 1 pt with combined bone/nodal progression. Post-docetaxel pts had pre-AA metastatic lesions located in bone (75%), lymph nodes (35%), lungs (5%) and liver (5%). Progression during AA therapy occurred in bone (80%), lymph nodes (75%), lungs (20%) and liver (5%). Only 1 pt met oligoprogression criteria with a single progressive bone metastasis. Conclusions: A sizeable number of men with chemotherapy-naïve mCRPC progressing during AA therapy might be considered for SABR. By contrast, progression of post-docetaxel mCRPC treated with AA is typically widespread. Further efforts are needed to identify criteria for oligoprogressive pts most suitable for SABR with sustained benefit versus men that may progress rapidly with widespread metastases following radiotherapy.
Dr. Robbins' Affiliation
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes Mellitus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2547: TERT promoter mutations in B viral humanhepatocarcinogenesis
Authors: Young-Joo Kim, Jeong Eun Yoo, Youngsic Jeon, Jae Uk Chong, Gi Hong Choi, Dae-Geun Song, Sang Hoon Jung, Bong-Kyeong Oh, Young Nyun Park
Journal: Cancer Research (2019)

Abstract Telomerase reverse transcriptase (TERT) promoter somatic mutations, related to telomerase activation, have been known to frequently occur at two hot spots located at -124 and -146 bp relative to the start codon in various cancers. In the present study, we investigated the occurrence and implications of the genetic alterations of the TERT promoter in B viral hepatocarcinogenesis. TERT promoter mutations, especially -124C&amp;gt;T mutation, obviously enhanced TERT promoter activity in hepatocellular carcinoma (HCC) cell lines. We identified prospero homeobox protein 1 (PROX1) as a novel transcriptional activator for TERT gene through binding to the promoter regions containing two hot spots. PROX1 binding affinity was strong to the mutant TERT promoter harboring a consensus E-twenty six/ ternary complex factor (ETS/TCF) binding sequence (CCGGAA). The incidence of TERT promoter mutations gradually increased according to the progression of human B viral multistep hepaticarcinogenesis, which was found in 9.0% of low grade dysplastic nodules (LGDNs), 13.5% of high grade dysplastic nodules (HGDNs), 27.3% of early HCCs (eHCCs) and 28.4% of progressed HCCs (pHCCs). The occurrence of TERT promoter mutations correlated with lower levels of alpha-fetoprotein (AFP) (p=0.046) and a poor overall survival (p=0.012) in B viral HCC patients. On the contrary to in vitro data, TERT mRNA expression was lower in B viral HCCs with the mutant TERT promoter compared to those without. In addition, mRNA level of PROX1 was not correlated with that of TERT in B viral HCCs, in contrast that such correlation was evident in non-B viral HCCs. Interestingly, induction of stable HBx expression inhibited PROX1-mediated TERT expression in vitro study. In conclusion, our findings suggest that TERT promoter somatic mutations are early events in B viral human multistep hepatocarcinogeneis and HBx can induce a loss of PROX1 function as transcriptional activator for TERT expression. Citation Format: Young-Joo Kim, Jeong Eun Yoo, Youngsic Jeon, Jae Uk Chong, Gi Hong Choi, Dae-Geun Song, Sang Hoon Jung, Bong-Kyeong Oh, Young Nyun Park. TERT promoter mutations in B viral humanhepatocarcinogenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2547.
β-thalassemia intermedia caused by compound heterozygosity for Hb Malay (β codon 19 AAC→AGC; Asn→Ser) and codons 41/42 (-CTTT) β0-thalassemia mutation
Authors: S K Ma, E Y Chow, A Y Chan, N N Kung, J S Waye, L C Chan, D H Chui
Journal: American Journal of Hematology (2000)

We report a case of beta-thalassemia intermedia caused by compound heterozygosity for hemoglobin (Hb) Malay and codon 41/42 (-CTTT) beta(0)-thalassemia mutation in a 38-year-old Chinese woman. This patient has long-standing anemia with a baseline Hb level of around 70 g/L. She worked as a full-time cashier and had not required regular blood transfusions. Nevertheless, she had splenomegaly necessitating splenectomy, cholelithiasis, and iron overload. This case illustrates the varied phenotypic expression associated with compound heterozygosity for Hb Malay and other beta-thalassemia mutations. Since Hb Malay migrates as Hb A on electrophoresis and chromatography, this variant Hb mutation ought to be included in the differential diagnosis for beta-thalassemia major or intermedia patients of Southeast Asian descent who are reported to have Hb A on the basis of Hb analysis. The possible presence of this mutation should also be considered in appropriate cases for genetic counseling in couples at risk of conceiving fetuses with beta-thalassemia major or intermedia.
THE AUTOPSY
Authors: HOWARD T. KARSNER
Journal: JAMA (1927)

The word autopsy is defined in Webster's International Dictionary for 1926 as a "dissection of a dead body for the purpose of ascertaining the cause, seat, or nature of a disease." The usual definition, however, fails to express the full significance of the procedure, and in this discussion I shall regard the term as meaning a postmortem examination of the body to determine the pathologic processes present, in their relation to clinical phenomena and history, their interest for the surviving relatives, their importance to the community as a whole, and their value in study of the cause, processes and nature of disease. In the modern sense, the autopsy is a complete examination of the thorax, abdomen, head and spinal canal, and such other regions as are necessary. The autopsy being a scientific inquiry, the record, both verbal and pictorial, should be objective, accurate and complete. It should cover not only
Therapeutics
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Byline and Table 1 Footnote
Authors: Ivan Miller, Carlos Camargo, Edwin Boudreaux
Journal: JAMA Psychiatry (2017)

Yuri Milaneschi, PhD; Femke Lamers, PhD; Wouter J. Peyrot, MD, PhD; Bernhard T. Baune, MD, PhD, MPH, FRANZCP; Gerome Breen, PhD; Abbas Dehghan, MD, PhD; Andreas J. Forstner, MD; Hans J. Grabe, MD; Georg Homuth, PhD; Carol Kan, MA, MBBS, MRCPsych; Cathryn Lewis, PhD; Niamh Mullins, PhD; Matthias Nauck, MD; Giorgio Pistis, PhD; Martin Preisig, MD, MPH; Margarita Rivera, PhD; Marcella Rietschel, MD; Fabian Streit, MD; Jana Strohmaier, PhD; Alexander Teumer, PhD; Sandra Van der Auwera, PhD; Naomi R. Wray, PhD; Dorret I. Boomsma, PhD; Brenda W. J. H. Penninx, PhD; for the CHARGE Inflammation Working Group and the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Correction: Cost-Effectiveness of Radiofrequency Ablation for Supraventricular Tachycardia
Journal: Annals of Internal Medicine (2001)

Letters20 November 2001Correction: Cost-Effectiveness of Radiofrequency Ablation for Supraventricular TachycardiaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-10-200111200-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In an article about the cost-effectiveness of radiofrequency ablation for supraventricular tachycardia (1), the text and the legend of Figure 2 were discrepant. In the legend, the labels for the line with circles and the line with triangles were inadvertently switched. The legend should read, “Triangles represent a monthly drug cost of $100, squares represent a monthly drug cost of $50, and circles represent a monthly drug cost of $10 (base case).” Thus, the higher the monthly drug cost, the more rapidly the cost of radiofrequency ablation is recouped.Reference1. Cheng CH, Sanders GD, Hlatky HA, Heidenreich P, McDonald KM, Lee BK, et al . Cost-effectiveness of radiofrequency ablation for supraventricular tachycardia. Ann Intern Med. 2000;133:864-76. [PMID: 11103056] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCost-Effectiveness of Radiofrequency Ablation for Supraventricular Tachycardia Carol H.F. Cheng , Gillian D. Sanders , Mark A. Hlatky , Paul Heidenreich , Kathryn M. McDonald , Byron K. Lee , Mary S. Larson , and Douglas K. Owens Metrics 20 November 2001Volume 135, Issue 10Page: 933KeywordsDrugsRadiofrequency ablationTachycardia ePublished: 20 November 2001 Issue Published: 20 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Basic Surgery
Authors: Berkeley Brandt
Journal: JAMA (1983)

<i>Basic Surgery</i>is a new approach to surgical texts. The editors and the 43 contributors have designed it to present to the student a discussion of surgically treated diseases based on the presenting complaint. The book is divided into four sections. The first, "General Approach to Surgery," discusses surgical attitudes and perspectives, the mathematics of clinical judgment, and anesthetic considerations. This serves as a general introduction and gives the reader a feeling for the author's overall philosophy. The second section, "The Physiology of Surgical Diseases," deals with basic principles that the student needs to understand regardless of the specific disease. This overview is somewhat brief, but covers the area well. The text is well augmented by the tables and illustrations. The charts in the chapter on fluid and electrolytes may be particularly helpful to the student. The approach in this section is not substantially different from other standard texts and,
Editor's quiz: GI Snapshot
Authors: J Tack
Journal: Gut (2004)

Background: It is not known which region of the stomach is responsible for symptom generation or whether symptoms induced by gastric distension are region specific.Also, it is unclear whether low level gastric distension has a modulatory role on gastric tone and mechanosensitivity.Aims: To define differences in the sensorimotor response to distension between proximal and distal gastric distension, and to determine the effects of low level gastric distension on gastric tone and mechanosensitivity.Methods: In 14 healthy volunteers, a double barostat assembly incorporating a distal (antral) and proximal (fundic) bag was introduced into the stomach.Pressure sensitivity tests with either bag were performed with and without simultaneous background distension of the other bag in a randomised manner.Proximal gastric accommodation to a meal was measured with and without simultaneous distal gastric distension.Results: The distal stomach was less compliant than the proximal stomach to low level distension.Thresholds for first perception and discomfort, and symptom profiles did not differ between distal and proximal gastric distension.Simultaneously applied low level gastric distension of one segment did not affect gastric mechanosensitivity of the other segment.Both the proximal and distal stomach relax after ingestion of a meal.Simultaneous low level antral distension decreases proximal gastric accommodation to a meal.Conclusions: Compared with the proximal stomach, the distal stomach is less compliant but its mechanosensitivity is not different.Symptoms induced by gastric distension are not region specific and no spatial summation occurred.Meal induced relaxation occurs both in the proximal and distal stomach.
Availability of Frozen Serum Panels
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Availability of Frozen Serum Panels Get access JNCI: Journal of the National Cancer Institute, Volume 71, Issue 1, July 1983, Page 223, https://doi.org/10.1093/jnci/71.1.223-a Published: 01 July 1983
Medicaid
Authors: Harriet L. Komisar
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal