tbuckley/cabot-search huggingface dataset:
P311 A COMMON POLYMORPHISM IN THE NCAN GENE IS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA IN ALCOHOLIC LIVER DISEASE
Authors: H.D. Nischalke, P. Lutz, B. Krämer, J. Söhne, T. Müller, J. Rosendahl, J. Fischer, T. Berg, M. Soyka, J. Nattermann, T. Sauerbruch, C.P. Strassburg, F. Stickel, U. Spengler
Journal: Journal of Hepatology (2014)
Hyperactivated mTOR and JAK2/STAT3 pathways: Crucial molecular drivers and potential therapeutic targets of inflammatory breast cancer (IBC).
Authors: Eleonora Teplinsky, Amanda Valeta, Rezina Arju, Shah Giashuddin, Yasmeen Sarfraz, Melissa Alexander, Farbod Darvishian, Deborah Silvera, Paul H. Levine, Salman Hashmi, Ladan Paul, Heather J. Hoffman, Baljit Singh, Judith D. Goldberg, Tsivia Hochman, Silvia Formenti, Robert Schneider, Komal L. Jhaveri
Journal: Journal of Clinical Oncology (2013)

60 Background: IBC is an aggressive form of breast cancer with poor prognosis. Combined multi-modality Rx results in a 5 year OS of 30-50%, underscoring the unmet need for targeted Rx. Our preclinical research in cell lines and xenografts identifies a role for activated PI3K/mTOR pathway in IBC. IBC cells express IL-6 and IL-8 and recruit tumor activated macrophages (TAMs) that further induce IL-6, IL-8 and activate the JAK2/STAT3 pathway. We investigated the independent and combined activity of these pathways in IBC tissues. Methods: Archived tissues of 42 IBC pts and 13 controls (nl breast) were analyzed using IHC and scored by 3 independent pathologists. Results defined as: 0, 1+ = neg; 2+ = pos for activated mTOR (P-S6) and 0 = neg; 1+, 2+ = pos for activated nuclear JAK2/STAT3 (P-JAK2; P-STAT3), cytokine (IL-6), macrophage (mØ) infiltration (CD68) and TAM (CD163). Proportions of IBC cases with pos expression were compared with controls (Fishers exact tests). Clinical and survival data were obtained. Results: Median age at diagnosis: 46 yrs (31-62) in early-stage IBC [EIBC] (n=37) and 41 yrs (29-57) in pts with de novo metastatic IBC [MIBC] (n=5). In EIBC, 19/36: HER2+ (1 unk); 8/19: ER+/HER2+; 8/36: ER-/HER2-. In MIBC, all were ER- (1 unk) and 3/4 were HER2+ (1 unk). 88% Rx with neoadjuvant and/or adjuvant anthracycline and taxane w/o adjuvant trastuzumab. 24 pts died (5/5 MIBC). Median OS: 86 mo (95% CI lower 48 mo) for EIBC &amp; 41 mo (95% CI 8-81 mo) for MIBC. Median RFS: 18 mo (95% CI 18-79 mo) for 23 pts (13 NED; 1 unk). All controls: neg for P-S6, JAK2, STAT3 and TAMs and 92% neg for mØ and IL-6. Proportion of IBC with pos expression when compared to controls listed in table (p &lt;0.0001). Of 31 pts with complete biomarker data who were PS6+, 97% had activated JAK2, 58% had activated STAT3, 80% had strong mØ and TAM infiltration and 97% were IL6+. Conclusions: This is the first study that validates preclinical findings and shows a strong association between mTOR, cytokines, TAMs and JAK/STAT pathways in most IBC pt tissues. Findings suggest a key role for dual blockade of mTOR and JAK/STAT pathways in phase I trials. [Table: see text]
Questionable methods of cancer management. Immuno-augmentative therapy (IAT)
Journal: CA A Cancer Journal for Clinicians (1991)

"Immuno-augmentative therapy" is a method of cancer management developed by Lawrence Burton, PhD. Dr. Burton states that IAT can control all forms of cancer by restoring natural immune defenses. He claims to accomplish this by injecting protein extracts isolated with processes that he has patented. However, experts believe that the substances he claims to use cannot be produced by these procedures and have not been demonstrated to exist in the human body. He has not published detailed clinical reports, divulged the details of his methods, published meaningful statistics, conducted a controlled trial, nor provided independent investigators with specimens of his treatment materials for analysis. During the mid-1980s, several cases were reported where patients of Dr. Burton developed serious infections following IAT.
THE TOE PHENOMENON OF BABINSKI.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predators
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Apnea and Respiratory Distress in the Newborn Infant
Authors: C. D. Cook, J. F. Lucey, J. E. Drorbaugh, S. Segal, J. M. Sutherland, C. A. Smith
Journal: New England Journal of Medicine (1956)

(Concluded)*Tank-Type RespiratorWhether expanding forces are applied to the lungs via a face mask with positive pressure or by means of negative pressure applied to the chest (and abdomen), the physiologic effects are similar. Thus, the same factors that contribute to safe expansion are important in both, and such complications as gastrointestinal distention are seen with both procedures. In actual use, the practical limitations of prolonged application of either a face mask or a tank respirator are most important.A tank or "iron-lung" respirator should, theoretically, be as useful as an electrophrenic respirator in the treatment of apnea, and . . .
Textbook of Tracheo-Bronchoscopy (Technical and Practical).
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply to Robert J. van Soest and Ronald de Wit's Letter to the Editor re: Johann S. de Bono, Matthew R. Smith, Fred Saad, et al. Subsequent Chemotherapy and Treatment Patterns After Abiraterone Acetate in Patients with Metastatic Castration-resistant Prostate Cancer: Post Hoc Analysis of COU-AA-302. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.06.033
Authors: Johann de Bono
Journal: European Urology (2016)
Meet the First Authors
Authors: Yuxuan Guo, Alanna Watson
Journal: Circulation Research (2017)

a PhD in Biology from the Johns Hopkins University, where he studied the role of nuclear lamins in nuclear lamina and mitotic spindle assembly.In 2015, he joined Dr William Pu's lab at Boston Children's Hospital to investigate cardiac myocyte maturation during heart development.Dr Guo's area of expertise is cytoskeleton biology.He believes that understanding the intricate interplay between cytoskeletal dynamics and transcriptional regulation is critical to uncover the principles governing cardiomyocyte maturation.His research goal as a postdoctoral trainee is to establish skills and tools to generate knowledge that can guide the engineering of mature iPSC-CMs.In his free time, Dr Guo enjoys basketball and playing with his daughter.
Protocol Deviations and Reanalyses in a Derivative Study of the PREDIMED Trial
Authors: Idris Evans, Derek Angus, Christopher Seymour
Journal: JAMA (2018)

Miguel Ruiz-Canela, PhD; Ramón Estruch, MD, PhD; Dolores Corella, DPharm, PhD; Jordi Salas-Salvadó, MD, PhD; Miguel A. Martínez-González, MD, PhD
Gallbladder wall thickening in preeclampsia
Authors: K. A. Gadwood
Journal: JAMA (1985)

Sonographic examination of the gallbladder in two patients with preeclampsia and right upper quadrant pain demonstrated notable thickening of the gallbladder wall. The sonographic abnormality and clinical symptoms completely resolved after delivery and/or medical management of the preeclampsia. This finding is probably secondary to the hypoalbuminemia characteristic of preeclampsia and should not be mistaken for intrinsic gallbladder disease. (<i>JAMA</i>1985;253:71-73)
Reviews &amp; Notices
Journal: BMJ (1879)

UNAQv 8, 1879.-through the abdominal walls, without* selecting an; particular spot; and, on Withdrawing the trocar, there was a rush of eir, followed, finally, by a small quantity of yellowish fluid, on the appearance of which the cannula was gently and steadily withdrawn, and the instru- ment reintroduced at another spot.3. This case further illustrates the uselessness, and even cruelty, of giving purgatives in intestinal obstruction.Up to a certain period, the patient's sufferings were by no means great; then a purgative was ad- ministered, and the intensity of his sufferings rapidly increased.What else could one expect in such a case?The sulphate of magnesia could do nothing but increase the watery exudations into the bowel, and so increase the pain and irritability.The routine administration of purga- tives in these cases, though not so frequent as formerly, is by no means unfrequent in the present day, and, to my mind, deserves nothing but condemnation, except, perhaps, in those cases where the obstruction is presumably a movable one.Even in such cases, I doubt whether it is n6t more rational treatment to administer remedies by the mouth which have a soothing and tonic effect on the coats of the intestines, such as belladonna, alone or combined with opium, or even ergot of rye, and to attack the movable obstruction by large enemata, and, perhaps, by the kneading of the bowels.
Table of Contents
Authors: Jay Portnoy, Aarti Pandya, Morgan Waller, Tania Elliott, Kansas City, Lily Pien, Colleen Colbert, Young Juhn, Hongfang Liu, Zuhair Ballas, Marc Rothenberg, Jean Bousquet, Anne Ellis, Charles Frankish, Kristen Armstrong, Lisa Steacy, Mark Tenn, Stephen Pawsey, Roderick Hafner, Sanne Meisser, Can Altunbulakli, Josefine Bandier, Morten Opstrup, Francesc Castro-Giner, ¨beccel Akdis, Charlotte Bonefeld, Jeanne Johansen, Cezmi Akdis, Shuli Li, Pan Kang, Weigang Zhang, Zhe Jian, Qian Zhang, Xiuli Yi, Sen Guo, Weinan Guo, Qiong Shi, Bing Li, Yuanmin He, Pu Song, Ling Liu, Kai Li, Gang Wang, Tianwen Gao, Chunying Li, Joanne China, Brent Sordillo, Sheryl Coull, Ann Rifas-Shiman, Sharon Wu, Marie-France Lutz, Sharon Jime ´nez Delgado, Susann Dehmel, Elaine Twisterling, Judy Wichmann, Danny Jonigk, Gregor Warnecke, Peter Braubach, Hans-Gerd Med, Ludwig Fieguth, Franziska Wilkens, Franz-Josef Dahlmann, Alexander Kaup, Sascha Eggel, Katherina Knauf, Armin Sewald
Journal: Journal of Allergy and Clinical Immunology (2020)
Criteria Reversed
Journal: JAMA (1966)

In Table 1 of the original contribution by Breslin et al on "Prognostic Importance of Ophthalmoscopic Findings in Essential Hypertension" (<b>195</b>:335-338 [Jan 31] 1966), the criteria for "grading of sclerosis" and those for "grading of general narrowing" are reversed, those for "grading of sclerosis" actually being those given for "grading of general narrowing," and vice versa.
SIMPLICITY THE SEAL OF TRUTH.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outbreak of Pneumonia Associated With a Cruise Ship, 1994
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatrics
Authors: Laurence Finberg
Journal: JAMA (1990)

Developments in the field of pediatrics over the past year or two have centered on a changing major subfield, neonatology, where events have either surprised or overtaken us, and on genetics, which is foreshadowing the future of pediatric care. Two controversial issues have also emerged: to test or not to test universally for cholesterol levels in children and how to react to the advertising of infant formula to the public. The argument for universal testing of children for cholesterol levels includes the following considerations<sup>1</sup>: (1) Atherosclerosis is the basis for more deaths in later life than any other cause. (2) Testing adult cholesterol levels leads to interventions that reduce coronary artery disease; therefore, it may have a similar beneficial effect in children. (3) Atherosclerosis begins in late childhood; therefore, early dietary intervention will be useful. (4) Testing only children from "high-risk" families misses many (some say as much as
Abstract 4685: Cancer associated fibroblasts promote ovarian cancer chemoresistance by inducing cancer stem cells through Wnt signaling
Authors: Yiming Fang, Mohamed A. Abd El Aziz, Kartikeya Tiwari, Anirban K. Mitra
Journal: Cancer Research (2019)

Abstract Ovarian cancer is the most lethal gynecologic malignancy and the 5th leading cause of cancer related deaths among women in the USA. Most patients eventually succumb to chemoresistant disease and the purpose of this study is to understand the mechanism of development of chemoresistance and disease relapse. Cancer stem cells (CSCs) consist of a small subpopulation in the tumor that are resistant to cytotoxic chemotherapy and cause relapse. The tumor microenvironment can potentially provide an optimal cancer stem cell niche for cancer stem cell growth and maintenance. Cancer associated fibroblasts (CAFs) are one of the main constituents of the tumor microenvironment in ovarian tumors, promoting tumor progression and chemoresistance. We have studied the potential role of CAFs in maintaining CSC population and enhancing chemoresistance with an objective to develop effective approaches to overcome chemoresistance and tumor relapse. Co-culture of high grade serous ovarian cancer cells with CAFs resulted in increased resistance to carboplatin. ALDH1A1 is a well-established marker for ovarian cancer CSCs and the ALDH+ population was significantly increased upon co-culture with CAFs. Similarly, CAFs also enhanced spheroid formation of ovarian cancer cells seeded in ultralow adhesion plates in CSC medium. Interestingly, co-culturing ALDH- ovarian cancer cells with CAFs resulted in the induction of ALDH+ cells within 6 days. Analysis of the signaling pathways activated in ovarian cancer CSCs and the gene expression profiles of ovarian cancer CAFs indicated the potential role of Wnt signaling in the productive cross-talk between CAFs and ovarian cancer CSCs. Treatment with Wnt inhibitors abrogated the induction of CSCs by CAFs. By selectively silencing porcupine, a protein involved in Wnt ligand lipidation and secretion, we further confirmed that CAF derived Wnts are responsible for the induction of CSC. Studies are ongoing to identify the specific Wnt ligand involved in the cross-talk and downstream pathways activated during CSC induction and maintenance by CAFs. Our results indicate that CAF-derived Wnt ligands are instrumental in ovarian cancer CSC growth and maintenance. In the long term, our studies will broaden the understanding of CSC maintenance by the tumor microenvironment and contribute towards the development of novel therapeutic approaches to prevent ovarian cancer chemoresistance and relapse. Citation Format: Yiming Fang, Mohamed A. Abd El Aziz, Kartikeya Tiwari, Anirban K. Mitra. Cancer associated fibroblasts promote ovarian cancer chemoresistance by inducing cancer stem cells through Wnt signaling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4685.
Nystagmus
Authors: Malcolm M. Kates, Casey J. Beal
Journal: JAMA (2021)

NystagmusNystagmus is a condition in which the eyes move involuntarily, typically in a rhythmic pattern. Types and Causes of NystagmusNystagmus can be categorized in different ways, including based on age at onset, type of eye movement, or specific cause.There are 2 major categories of nystagmus related to when the disease occurs.Congenital nystagmus is present shortly after birth.Acquired nystagmus begins after 6 months of life.Congenital motor nystagmus is the most common type of congenital nystagmus.This usually occurs by itself, is not associated with any other congenital abnormalities, and does not go away but can lessen with time.Other causes of congenital nystagmus include developmental abnormalities in the eye structures, such as the cornea, lens, retina, and optic nerve, or abnormalities in the visual pathways in the brain.Acquired nystagmus has several medical and neurologic causes, including certain medications, stroke, brain injuries or tumors, and diseases of the vestibular system.When vestibular organs are not functioning normally, the body has a difficult time balancing and may induce nystagmus.A clinician can evaluate for the different causes by taking a thorough history, by physical examination, and sometimes with blood tests and imaging.
Organ procurement: expenditures and financial incentives
Authors: F. A. Sloan
Journal: JAMA (1993)

... One is struck by the high level of organ procurement charges in spite of the characterization of organ procurement as altruistic. Although the median organ procurement charges in 1988, documented by Evans, ranged from nearly $16,000 to nearly $21,000 (1991 dollars), there was not a penny for the accident victim's/organ donor's family. That some transplant hospitals routinely marked up charges they paid to organ procurement organizations by as much as 200% hardly seems consistent with altruism. Viewed generously, organ recipients and payers on their behalf are being asked to cross-subsidize other worthy causes in which transplant hospitals engage. If the organ procurement system is to remain altruistic, not only is cost per procured organ an issue but more equitable sharing of costs would seem in order....
Breast cancer in women with primary biliary cirrhosis
Authors: B M Goudie, A D Burt, G Macfarlane, G G Birnie, R N M Macsween, G Watkinson, P Boyle, C R Gillis
Journal: BMJ (1986)

Mean (SEM) urea and creatinine concentrations before and after plasma exchange* in 24 patients Before After Urea (mmol/l) 27-1 (310) (2-5)Creatinine (pmol/l) 631 (99) 387 (75) *Two or three exchanges of 3-4 litres.Convon: SI to traditol units-Urea: 1 mmolll 6 mg/100 ml.Creatinine: 1 smol/lO-O1 mg/100 ml.due to plasma exchange improving rehydration but also to efficient mechanical removal of toxic immunoglobulins.This would prevent further, and possibly more permanent, tubular damage, while allowing chemotherapy time to take effect.In our study, as well as improving renal function, plasma exchange was associated with longer survival in some cases.6We suggest that early plasma exchange may be an additional therapeutic option in patients with myeloma, circulating light chains, and renal insufficiency, helping to prevent the progression to irreversible toxic renal damage, chronic renal failure, and ultimately deaih.