tbuckley/cabot-search huggingface dataset:
Confocal microscopy immunofluorescence localization of desmin and other intermediate filament proteins in fetal rat livers
Authors: J Vassy
Journal: Hepatology (1993)

Immunolocalization of desmin in fetal rat livers shows that on day 12 of gestation a high number of liver cells express desmin. This number decreases from day 14 onward. On day 20 about the same density of desmin-containing cells is found in fetal rat livers as is found in adult rat livers. Desmin-containing cells show two types of labeling patterns, especially on days 12 and 13 of gestation: (a) a basketlike network of intermediate filaments throughout the whole cell, similar to the labeling pattern of cytokeratin in hepatocytes; and (b) more strongly labeled intermediate filaments developing long and slender processes between adjacent cells, close to the labeling pattern of Ito cells in adult rats. From day 14 of gestation, the first type becomes rare, and from day 18 only the second type remains. Double-labeling experiments show that coexpression of desmin and cytokeratin is found in cells of the first type on days 12, 13 and 14 of gestation. Cells containing desmin with the labeling pattern of the second type never express cytokeratin. Coexpression of vimentin and cytokeratin is never found in fetal hepatocytes, even on day 12 of gestation. Numerous nonhepatocyte cells coexpress desmin and vimentin, but some cells contain vimentin or desmin alone. In desmincontaining cells the labeling pattern is of the first type (basketlike network). These results suggest that in early stages of fetal liver development, desmin is found in two different types of liver cells. Cells of the first type contain cytokeratin and desmin, and those of the second type contain desmin and vimentin, as Ito cells in adult liver tissue. Cells of the first type might represent a particular type of fetal hepatocyte. The existence of these two types of desmin immunolocalization is in convergence with electron microscopic data showing numerous lipid droplets both in fetal hepatocytes and in perisinusoidal cells. It is generally admitted that fetal liver differentiation is the result of the close association between endodermal and mesenchymal cells. Among the latter, desmin-containing cells (fetal Ito cells) might play a crucial role, especially because they are known to contain vitamin A and to express a hepatocyte growth factor in the normal adult liver. (HEPATOLOGY 1993;17:293–300.)
Detection of a venous collateral pathway by mammography: superior vena caval syndrome
Authors: G. K. McLean
Journal: JAMA (1978)

THE SYNDROME of superior vena caval syndrome (SVCS) may be associated with a variety of patterns of collateral circulation. We report the case of a patient with SVCS who had a unique route of collateral circulation consisting of a superficial breast vein discovered in the course of routine mammography. This finding provided a clue to the cause of a mediastinal pseudotumor in the chest roentgenogram that resulted from dilation of the left superior intercostal and accessory hemiazygous veins. <h3>Report of a Case</h3> In 1970 a 35-year-old woman entered the emergency room of the Hospital of the University of Pennsylvania with chief complaint of swelling in the left axilla for two days. A chest x-ray showed a mediastinal mass, and the patient was admitted for further study. Additional history included tightness in the throat and anterior superior chest wall for approximately one year, mild shortness of breath on exertion, and intermittent
Authors' response
Authors: S. V. Kemp, P. L. Shah
Journal: Thorax (2010)

The factors that regulate the migration of antigen-specific CD8 T cells after infection are not well understood. Although, it is known that sphingosine-1-phosphate receptor 1 (S1P1) controls naïve T cell trafficking, our understanding of how S1P1 regulates the migration of effector CD8 T cells after infection remains poorly defined. Here we used novel mouse models to investigate the role of S1P1 in the migration of effector CD8 T cells in draining lymph node (dLN). By using in-situ tetramer staining we mapped the endogenous antigen-specific CD8 T cell response after viral infection in the dLN. We observed that effector CD8 T cells followed a multistage pathway within the dLN that included the localization of CD8 T cells in T cell zones early after infection, followed by the migration of these cells into B cell zones before exiting out of the dLN via the subcapsular and cortical lymphatic sinuses. Furthermore, we used a granzyme B-YFP reporter mouse and two-photon intravital microscopy to analyze the dynamic behavior of endogenous effector CD8 T cells after infection. Finally, we generated S1P1 conditional YFP knock-out mice to disrupt S1P1 signals specifically and temporally in effector CD8 T cells after infection. Taken together, our studies clearly demonstrate that after infection, even in the absence of retention signals such as CCR7 and CD62L, S1P1 signaling is the overriding factor that regulates effector CD8 T cell migration in the dLN.
1973 PROGRAM AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, INC. 65TH ANNUAL MEETING
Authors: B Maron, V Ferrans, W Roberts, A Morrow, S Epstein, Radioimmunoassay Starr, D Juhn, M Mako, M Guerin, A Scanu, A Rubenstein, Harold Fallon, James Mcguigan, S Shefer, S Kim, Yong Kim, Marvin Sleisenger, Lavonne Veatch, Marshall Kaplan, Philip Fialkow, Charles Scriver, Gerald Perkoff, Inner City, Area Lille, J Gould, M Viera, B Garo, A Chobanian
Journal: Journal of Clinical Investigation (1973)
Apatitic urinary calculi from early American Indians
Authors: C. W. Beck
Journal: JAMA (1966)

Ancient urinary calculi have been reported sparingly in the literature. The first known vesical stone was discovered by Elliot Smith among bones of a predynastic Egyptian who lived before 4800 BC.<sup>1</sup>Indian Sanskrit documents mention suprapubic removal of calculi. These artisans further recognized that broken fragments from a calculus could act as nucleating centers for renewed stone growth. Hippocrates (460-370 BC) identified both renal and vesical calculi. Willams<sup>2</sup>discovered a bladder stone in the mummy of a basket-maker's grave in Arizona that dated back at least 3,000 years. Smith<sup>3</sup>analyzed genitourinary-tract calculi from a skeleton in a burial at Indian Knoll, Ky. The present study is concerned with the occurrence of urinary calculi from two midwestern Indian burials in Fulton County, Illinois, and Marion County, Indiana. These two occurrences, as well as those reported in the literature, indicate that early man apparently suffered from urinary-tract diseases similar
Book Reviews
Journal: Allergy (1981)

Book reviewed in this article: Johnson, F. (ed.): Allergy, including IgE in diagnosis and treatment. Steffen, C. &amp; Ludwig, H. (eds.): Clinical immunology and allergology Stiehm, E. R. &amp; Fulginiti, V. A. (eds.): Immunologic disorders in infants and children. Holboraw, E.J. (ed.): Autoimmunity. Clinics in immunology and allergy. Safai, B. &amp; Good, R. A. (eds.): Immunodermatology.
Alopecia and sensory polyneuropathy from thallium in a Chinese herbal medication
Authors: H. H. Schaumburg
Journal: JAMA (1992)

<h3>In Reply.</h3> — We concur with Dr Goffen's concern about the "remarkable variability" of reporting of adverse actions and malpractice payments on physicians throughout the United States. Indeed, much of the variability in the observed rates derives from the variability in practices relating to disciplinary actions and reporting rather than to the quality of the physicians in a given state or locale. This same problem presents itself to physicians engaged in credentialing or peer review work. It is their job to assess information provided to them by the physician in question or from other sources when deciding whether to grant privileges, licenses, and membership. The NPDB simply makes that information available in a uniform and regularized fashion. The task of peer review and decision making remains firmly in the hands of physician-led credentialing authorities. One can only agree with Goffen's concern about the apparent irregularity in the system. The solution
Blood pressure influences end-stage renal disease of Cd151 knockout mice
Authors: Norman Sachs, Nike Claessen, Jan Aten, Maaike Kreft, Gwendoline J.D. Teske, Anneke Koeman, Coert J. Zuurbier, Hans Janssen, Arnoud Sonnenberg
Journal: Journal of Clinical Investigation (2012)

In the second paragraph of the Introduction, the final two sentences were incorrect.The correct sentences are below.Finally, individuals with non-type O blood have decreased clearance of von Willebrand factor (vWF).Since FVIII circulates in plasma bound to vWF, an increase in plasma vWF is also associated with increased levels of FVIII.The author regrets the error.
BOOK REVIEW
Authors: S. E. ORDER
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article BOOK REVIEW Get access Cancer Therapy With Radiolabeled Antibodies David M. Goldenberg , ed. Boca Raton, Fla. : 1995 . 326 pp., illus. $229. ISBN 0-8493-5112-X STANLEY E. ORDER, M.D. STANLEY E. ORDER, M.D. Institute for Systemic Radiation Therapy, Department of Radiation Oncology, Cooper Hospital/University Medical CenterCamden, NJ 08103 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 5, 1 March 1995, Page 387, https://doi.org/10.1093/jnci/87.5.387 Published: 01 March 1995
Book Review The Neuroses in War . By several authors under the editorship of Emanuel Miller, M.A. (Cantab.), M.R.C.P., D.P.M. (Camb.), with a concluding chapter by H. Crichton-Miller, M.D., F.R.C.P. 8°, cloth, 250 pp. New York: Macmillan Company, 1940. $2.50.
Journal: New England Journal of Medicine (1941)
Helicobacter pylori
Authors: Defaecation Kumar, Defect Benson, R Leicester, Ka Nicholson, D Etles, G Duthie, P Rlee, J Monson
Journal: Gut (1996)

Assessment of rectal transit is commonly performed using barium proctography.The result obtained from such measurements only reflect total percentage evacuation from the rectum and do not take into account the rate of evacuation.The aim of this study was to evaluate the impact of the rate of evacuation and total.We studied 104 patients with a history of constipation.Rectal transit was measured using isotope defaecography in an unprepared rectum.Gamma camera images were obtained at 5 second intervals during the act of defaecation.The rectal transit was normal in 29 patients with a total percent evacuation of > 70% and a rate of evacuation of > 1.5% per second [70.5 (3.5), 1.5 (0.22)].There were no associated anatomical abnormalities such as a rectocele in this group.The remaining 75 patients had impaired rectal transit.The total percent evacuation in this group was significantly lower than the one with >70% evacuation (70.5 (3.15) vs 60.5 (1.9).The rate of rectal evacuation in those with reduced percent evacuation was significantly slower (p <0.05) than those with normal evacuation.There was a significant correlation between the rate of evacuation and total percentage evacuation (r=0.46,p<0.0001).There was an inverse correlation between the rate of evacuation and the presence of a rectocele (r=0.28,p<0.005).These data suggest that the rate of evacuation is an important factor in the dynamics of defaecation and should be routinely measured in patients with disordered defaecation.W42
Clinical trials financial compliance: The Principal Investigators and liability
Authors: K. Willenberg
Journal: Journal of Clinical Oncology (2004)

6097 Background: Clinical trials compliance has become more scrutinized with the national coverage decision and billable services. Meticulous financial planning is essential to fiscal success. Cost effective achievement through billing and accounts receivable will ensure compliance with federal guidelines. A clinical trials office conducting audits of patients" bills minimizes problems in billing compliance. Methods: A large clinical trials office manually reviewed HCFA Uniform Bill-92 for accuracy in charging. A conscientious effort was made to properly identify protocol specific research procedures and tests and budgets were established with accuracy. Standard of care, routine tests were acknowledged and an effort was made to code properly. "Research only" tests and procedures were placed on proper account as a new encounter form was established within the Cancer Clinic. In-services were executed to advise staff of agreed upon budget. Patients' bills were reconciled against schedule of events calendars and study milestones by nurse and administrative assistant. Accuracy in HCFA Uniform Bill charges increased by 50%. Results: Patients and third party payers were not billed inappropriately for research related activities. Patients bills were hand tracked when they had certain types of third party payers to ensure billing compliance. Sponsored research was appropriately and accurately contracted to cover research related activities. Financial and research compliance have become a priority for the University with new positions created to continue to work on processes for the future. Conclusions: Clinical research priorities include billing process improvement, compliance monitoring, and clinical trials management. Training and educational opportunities for precision budgeting are being initiated with the goal of offering a standardized budget formatting tool within the next few months. A review process by a specialized clinical trials budget expert has begun to assess financial feasibility and risk, as well as tracking billing compliance. No significant financial relationships to disclose.
New Therapies Available Under Treatment IND
Authors: Stuart L. Nightingale
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians and Patient Spirituality
Authors: John Graner
Journal: Annals of Internal Medicine (2002)

Letters3 September 2002Physicians and Patient SpiritualityJohn Graner, MDJohn Graner, MDMayo Clinic; Rochester, MN 55905Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-5_Part_1-200209030-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In my previous letter, I was not referring to constitutional legalities, so I did mean to use the word “politics.” I did not address the issue of whether it is constitutionally legal to display a religious icon in a medical office. Rather, I am primarily concerned with the meaning of such display. This meaning varies according to the nature of the activities taking place within that office. Similarly, it does not matter whether Dr. LeGrand's office is a “governmental” one or not. As a matter of fact, very little true political activity takes place in most governmental offices! ...Reference1. Arendt H. Between Past and Present. New York: Penguin Books; 1987:41-90. Google Scholar Author, Article, and Disclosure InformationAuthors: John Graner, MDAffiliations: Mayo Clinic; Rochester, MN 55905 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPhysicians and Patient Spirituality Gerald P. Bodey Physicians and Patient Spirituality John Graner Physicians and Patient Spirituality Susan B. LeGrand Physicians and Patient Spirituality Susan B. LeGrand Physicians and Patient Spirituality Fritz Baumgartner Metrics Cited byPhysicians and Patient SpiritualityFritz Baumgartner, MD 3 September 2002Volume 137, Issue 5_Part_1Page: 372KeywordsPatients ePublished: 3 September 2002 Issue Published: 3 September 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Author Correction: Liver macrophages regulate systemic metabolism through non-inflammatory factors
Authors: Cecilia Morgantini, Jennifer Jager, Xidan Li, Laura Levi, Valerio Azzimato, André Sulen, Emelie Barreby, Connie Xu, Michaela Tencerova, Erik Näslund, Chanchal Kumar, Francisco Verdeguer, Sara Straniero, Kjell Hultenby, Niklas K. Björkström, Ewa Ellis, Mikael Rydén, Claudia Kutter, Tracey Hurrell, Volker M. Lauschke, Jeremie Boucher, Aleš Tomčala, Gabriela Krejčová, Adam Bajgar, Myriam Aouadi
Journal: Nature Metabolism (2019)
Contents
Authors: R Moreau, R Bataller, T Berg, J Zucman-Rossi, R Jalan, S Lunemann, G Martrus, A Ho, A Chapel, M Ziegler, C Ko, Garcia Beltran, M Carrington, H Wedemeyer, M Altfeld, U Veterans Born, S Sarkar, D Esserman, M Skanderson, F Levin, A Justice, J Lim, N Bulteel, P Sarathy, E Forrest, A Stanley, H Innes, P Mills, H Valerio, R Gunson, C Aitken, J Morris, R Fox, S Barclay, W Bernal, N Murphy, S Brown, T Whitehouse, P Bjerring, J Hauerberg, H Frederiksen, G Auzinger, J Wendon, F Larsen, M Bitzer, M Horger, E Giannini, T Ganten, M Wo, J Siveke, M Dollinger, G Gerken, M Scheulen, H Wege, V Zagonel, U Cillo, F Trevisani, A Santoro, V Montesarchio, N Malek, J Holzapfel, T Herz, A Ammendola, S Pegoraro, B Hauns, A Mais, U Lauer, S Henning, B Hentsch, G Abou-Alfa, O Puig, B Daniele, M Kudo, P Merle, J.-W Park, P Ross, J.-M Peron, O Ebert, S Chan, T Poon, M Colombo, T Okusaka, B.-Y Ryoo, B Minguez, T Tanaka, T Ohtomo, S Ukrainskyj, F Boisserie, O Rutman, Y.-C Chen, C Xu, E Shochat, L Jukofsky, B Reis, G Chen, L Laurenzio, R Lee, C.-J Yen, J Yan, A Mitra, J Hu, J Cutrera, X Xia, T Doetschman, M Gagea, L Mishra, S Li, M Nadim, F Durand, J Kellum, J Levitsky, J O'leary, C Karvellas, J Bajaj, A Davenport, P Angeli, S Caldwell, J Ferna ´ndez, C Francoz, G Garcia-Tsao, P Gine, M Ison, D Kramer, R Mehta, D Mulligan, J Olson, E Pomfret, M Senzolo, R Steadman, R Subramanian, J.-L Vincent, Y Genyk, D Pinato, J Stebbing, M Ishizuka, S Khan, H Wasan, B North, K Kubota, R Sharma, T Bittermann, G Makar, D Goldberg
Journal: Journal of Hepatology (2016)
Multiple immuno-regulatory defects in type-1 diabetes
Authors: Anjli Kukreja, Giulia Cost, John Marker, Chenhui Zhang, Zhong Sun, Karen Lin-Su, Svetlana Ten, Maureen Sanz, Mark Exley, Brian Wilson, Steven Porcelli, Noel Maclaren
Journal: Journal of Clinical Investigation (2002)

Susceptibility to immune-mediated diabetes (IMD) in humans and NOD mice involves their inherently defective T cell immunoregulatory abilities. We have followed natural killer (NK) T cell numbers in patients with IMD, both by flow cytometry using mAbs to the characteristic junctions found in the T cell receptors of this cell subtype, and by semiquantitative RT-PCR for the corresponding transcripts. Both before and after clinical onset, the representation of these cells in patients' PBMCs is reduced. We also report low numbers of resting CD4+ CD25+ T cells in IMD patients, a subset of T cells shown to have important immunoregulatory functions in abrogating autoimmunities in 3-day thymectomized experimental mice. Whereas a biased Th1 to Th2 cytokine profile has been suggested to underlie the pathogenesis of IMD in both species, we found defective production of IFN-γ in our patients after in vitro stimulation of their PBMCs by phorbol-myristate acetate and ionomycin and both IFN-γ and IL-4 deficiencies in Vα24+ NK T–enriched cells. These data suggest that multiple immunoregulatory T (Treg) cell defects underlie islet cell autoimmunity leading to IMD in humans and that these lesions may be part of a broad T cell defect.
Abstract 2168: Sirolimus-eluting Stent Implantation at Proximal Site Inhibits In-stent Restenosis in Bare Metal Stent Placed at Distal Site of <i>de novo</i> Lesion in Same Coronary Artery
Authors: Hajime Takano, Jyun-ei Obata, Yoshinobu Kitta, Yasushi Kodama, Akira Mende, Takamitsu Nakamura, Keita Sano, Mitsumasa Hirano, Kiyotaka Kugiyama
Journal: Circulation (2007)

Drug-eluting stent (DES) suppresses peri-stent distal edge stenosis via a local diffusion of the drug. Diffusion of sirolimus into coronary blood flowing may cause an accumulation of this drug in coronary bed beyond the distal edge of sirolimus-eluting stent (SES). Thus, this study examined whether SES implantation may exert anti-proliferative action on bare metal stent (BMS) placed distally in the same coronary artery. Methods and Results: We prospectively examined 114 consecutive patients with stable coronary artery disease who met the following inclusion criteria: elective, successful percutaneous coronary intervention for a long de novo lesion or two adjacent de novo lesions treated with more than two stents in the same coronary artery, implantation of BMS (2.25 mm in size, 12 ~ 18 mm in length) in the distal site because no DES was available due to small vessel size, quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS) at stent placement and at 6 months or during the 6 months follow up after the stenting. At the proximal site adjacent to the distal BMS, SES was implanted without gap in 57 patients (SES-BMS), and BMS in the remaining 57 patients (BMS-BMS). Patients with in-stent restenosis (ISR, defined as &gt; 50% diameter stenosis), developed at the proximal stent during the 6 months follow up, were excluded from the further analysis (all of them were 14 patients with BMS-BMS). Clinical, lesion, and procedural variables at stenting were comparable between SES-BMS (n = 57) and BMS-BMS (n = 43) groups. The QCA of the distal BMS showed less late luminal loss (0.49 ± 0.06 vs. 0.91 ± 0.08 mm, p &lt; 0.01) and a lower ISR rate (13% vs. 36%, p &lt; 0.01) in the SES-BMS group than the BMS-BMS group. The SES-BMS group also had less neointimal hyperplasia volume (25.1 ± 2.2 vs. 37.1 ± 2.5 mm 3 , p &lt; 0.01) than the BMS-BMS group in the IVUS which examined a 10-mm length of the distal BMS from the distal edge of the proximal stent. Target lesion revascularization (TLR) of the distal BMS was less frequent in the SES-BMS group compared with the BMS-BMS group (9% vs. 19%, p &lt; 0.01). Conclusions: SES implantation inhibits ISR and TLR in BMS at distal site of de novo lesion in same coronary artery. These findings may have an implication for stent strategy in long lesions.