tbuckley/cabot-search huggingface dataset:
Activity of the new cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients
Authors: Laura Zamorano, Carlos Juan, Ana FernÃ¡ndez-Olmos, Yigong Ge, Rafael CantÃ³n, Antonio Oliver
Journal: Clinical Microbiology and Infection (2009)

Chronic respiratory infection caused by Pseudomonas aeruginosa is the main driver of morbidity and mortality in cystic fibrosis (CF) patients. The development of resistance to all available antibiotics is a frequent outcome of these infections. The present study aimed to evaluate the activity of the new cephalosporin CXA-101 (FR264205) against a collection of 100 isolates obtained from 50 CF patients from two Spanish hospitals. The collection included the first (early) and the last (late) available isolate from each patient (average interval 68 ± 39 months). The MIC50 and MIC90 of CXA-101 were 0.5 and 2 mg/L and the geometric mean MIC was 0.7 mg/L; the MICs for 95% of the isolates were ≤8 mg/L (tentative breakpoint). Only meropenem yielded comparable results, although the MIC90 of this antibiotic was significantly higher (8 mg/L). CXA-101 showed conserved activity against a high proportion of isolates resistant to each of the antibiotics tested (ceftazidime, cefepime, piperacillin-tazobactam, imipenem, meropenem, levofloxacin and tobramycin), with MIC50 values of 1-2 mg/L. Moreover, CXA-101 retained good activity against multidrug-resistant strains, with MIC50 and MIC90 values of 2 and 16 mg/L. CXA-101 was also active against late CF isolates (the MIC for 96% was ≤8 mg/L); it was the only antibiotic tested to which a similar percentage of early and late isolates was susceptible. These results show that, despite a slight increase in MICs, major cross-resistance to CXA-101 did not develop during treatment of CF patients with the currently available antipseudomonal agents. Therefore, CXA-101 is envisaged as a valuable alternative for the treatment of chronic respiratory infection caused by P. aeruginosa in CF patients.
Response
Authors: S. G. BAKER, L. S. FREEDMAN
Journal: JNCI Journal of the National Cancer Institute (1995)

ResponseWe thank Dr. Pollak for his correspondence.First, we should clarify that our article (J) was not intended, as he suggests, to analyze the impact of genetic testing specifically on the NSABP breast cancer prevention trial, although we used the design of that trial as our example.We agree with Dr. Pollak that an intervention may result in different benefits for mutation carriers and noncarriers, and we comment on this issue in the "Discussion" section of the article (1).Because most ongoing trials have been designed to test for an overall benefit, they do not have sufficient power to test separately for a benefit among carriers and noncarriers unless the interaction effect is unusually large.If a large difference in benefits between carriers and noncarriers were suspected, it would be necessary to design a much larger trial to separately detect the difference in each of the subgroups.
Future of Clinical Pharmacology
Authors: R. J. Ancill, D. A. Norton
Journal: BMJ (1967)

to the start of another, with perhaps a lower peak on this occasion because of improved environmental conditions and hygienic stan- dards.The fact that the disease has been notifiable and therefore susceptible to some extent to public health action from 1944 onwards may also have had some influence on reducing its severity, but this is largely con- jecture.-I am, etc.,
Erratum: Corrigendum: TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
Authors: Katharina Gerlach, YouYi Hwang, Alexej Nikolaev, Raja Atreya, Heike Dornhoff, Stefanie Steiner, Hans-Anton Lehr, Stefan Wirtz, Michael Vieth, Ari Waisman, Frank Rosenbauer, Andrew N J McKenzie, Benno Weigmann, Markus F Neurath
Journal: Nature Immunology (2015)
Aus der Medizin des Rinascimento an der Hani des Leben von Benvenuto Cellini nach der Übersetzung Goethes.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery
Authors: Arthur E. Baue
Journal: JAMA (1984)

Removal of the rectum and anus for a benign, chronic, or even for a life-threatening disease such as malignancy has always been repugnant to patients and surgeons. Ileostomies or colostomies, although lifesaving, create problems and detract from an optimal quality of life. Attempts to improve ostomy function by continent ileostomies such as the Kocks pouch also produce problems, particularly "pouchitis," with inflammation, partial obstruction, stasis, and steatorrhea with abnormalities of calcium metabolism. Enterostomal therapy has made the life of a patient with an ostomy easier but still less than satisfactory. The goal of preservation of the anus has been a recent major advance, and a number of approaches and methods have been used. These include better methods of low anterior resection for carcinoma of the colon, local excision and/or radiation by implantation for certain rectal cancers, and anorectal pullthrough procedures. These have all increased the possibility of adequate treatment of
Journal of Histochem and Cytochem, Baltimore
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemical, Biological Weapons Are Just as Potent as Nuclear Ones
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
REPORT CXII. OBSERVATIONS ON THE PHYSIOLOGY OF THE FEMALE GENITAL ORGANS
Authors: W. B. Bell, P. Hick
Journal: BMJ (1909)

general parasitological reasons; (b) in contradiction with a number of biological and anatomo-pathological facts (for example, the incapability on the part of the miracidium to resist the action of acids, even if very diluted; the part played in the infection by the liver, etc.).4. The theory of infection by the skin is in accordance with all the facts thus far known (a) of the biology of the parasite, (b) of the distribution of the disease among the population (native and foreign, town and rural) of Egypt.It shows (c) how the chief sufferers-the children in town, the adult males in the country-live under conditions which, from the epidemiological point of view, are essen- tially the same, and give the miracidia (d) the opportunity of passing, within the short time of their life, from man to water and from water back to man.
FUNGUS INFECTIONS
Authors: Robert Oblath
Journal: JAMA (1952)

<h3>To the Editor:—</h3> In the editorial "Fungus Infections Complicating Antibiotic Therapy," which appeared inThe Journal, June 21, 1952, page 762, mention is made that my co-workers and I reported six instances of pulmonary moniliasis. This notation is inserted in a paragraph in such a way that it would appear that these six instances followed the use of one of the antibiotics discussed in the article. I would like to correct this impression and note that all the patients studied had pulmonary moniliasis and received no antibiotic therapy and that each of these patients was studied in the era before aureomycin, chloramphenicol, and terramycin came into general use.
Accelerated progression of chronic renal insufficiency after parathyroidectomy
Authors: V. U. Collier
Journal: JAMA (1980)

Three patients with chronic renal failure developed secondary hyperparathyroidism, complicated by severe bone disease in two patients and by acral skin necrosis in the third. Following subtotal parathyroidectomy, the bone disease and the necrotic lesions rapidly improved, but the rate of loss of renal function accelerated concomitant with administration of calcium and vitamin D, although no hypercalcemia developed. Avoiding postoperative administration of calcium and/or vitamin D, unless indicated for symptomatic hypocalcemia, may prevent accelerated loss of renal function in patients requiring subtotal parathyroidectomy. (<i>JAMA</i>244:1215-1218, 1980)
ANTIVIVISECTIONIST SENTIMENTALITY AND BRAIN DEFORMITY IN THE DEGENERATE.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Not all drug firms subject to gifts guidelines, but, for physicians, their gifts are still taboo
Authors: T. Randall
Journal: JAMA (1991)

WHILE the Pharmaceutical Manufacturers Association (PMA) has agreed to enforce among its members the American Medical Association's (AMA's) guidelines concerning gifts from industry, non-PMA members fall outside the association's authority. The situation has created an open loop in which it is not technically unethical for nonmember companies to offer extravagant gifts, yet it is unethical for physicians to accept them. <h3>Firm Offers 'Educational Cruise'</h3> Ethics codes are not the law, however, and a recent promotion by a biomedical company indicates that many physicians still are more than willing to accept these gifts. Collagen Corp, Palo Alto, Calif, is sending the 55 dermatologists who purchased the largest volume of injectable collagen between July 1990 and March 1991 on an 8-day "educational cruise" in the South Pacific, all expenses paid. Winners of the trip were notified last month and the cruise is scheduled for late June. Howard D. Palefsky, chief executive officer
Marine Envenomations
Authors: Jane F. Desforges, Paul S. Auerbach
Journal: New England Journal of Medicine (1991)

DANGEROUS aquatic animals can be divided into four groups: those that bite, those that sting (envenom), those that are poisonous if eaten, and those that can deliver an electric shock. This discussion focuses on the treatment of victims of marine envenomations. Although most serious envenomations occur in the temperate or tropical waters of the Indo-Pacific region, North American coastal waters also provide a habitat for many dangerous stinging creatures. The toxin is delivered to the victim from venom glands attached or adjacent to spines (fangs, daggers, or darts) or from microscopic coelenterate stinging organelles called cnidae. When the identity of . . .
Leads from the MMWR. Heterosexual transmission of human T-lymphotropic virus type III/lymphadenopathy-associated virus
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIETY PROCEEDINGS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myoclonus associated with high doses of morphine.
Journal: BMJ (1989)

together with doxepin and amitriptyline under the heading antipsychotics, whereas the (largely D2) dopamine receptor blocking drugs thiethylperazine, metoclopramide, prochlorperazine, and domperidone appear under a separate heading of antinauseant drugs.This does not make pharmacological sense.As I see it, the point of this study is not that eight of 13 patients with side effects were taking antipsychotics and six of 13 were taking antiemetics, but rather that 12 of 12 patients with involuntary movements were taking dopamine receptor blocking drugs, which, unlike morphine, are widely recognised as a frequent cause of a wide variety of involuntary movements, including myoclonus.2Rather than concluding that "myoclonus as a side effect of treatment with morphine is more likely to occur in patients taking antidepressants or antipsychotic drugs as antiemetics or as adjuvant agents," I would pose the question, Does morphine treatment increase the likelihood of neuroleptics causing certain involuntary movements?
Cutaneous gnathostomiasis
Authors: Jeffrey J Crowley, Youn H Kim
Journal: Journal of the American Academy of Dermatology (1995)

1 at the same time an abrasive white powder was dispersed.Immediately thereafter, she noticed a "raw, red rash" along her mid-chin and neck area associated with mild burning and pmritus.Examination on day 6 revealed a 3 x 4 cm abrasion on her chin and scattered 1 to 2 cm erythema tous lesions along her neck (Fig. 1).Topical hydrocorti sone 1% ointment was prescribed, and healing occurred without consequence. DISCUSSIONThe air bag commonly installed in cars in the United States is a rubberized nylon bag with a diameter slightly larger than the steering wheel.At its central point, it measures approximately 10 inches in depth when fully inflated.There are two models: the untethered air bag whose impact surface is round and the tethered bag whose central surface is depressed.Rapid deceleration (experienced primarily with frontal impact) activates the ignition of a sodium azide propellant cartridge whose combustion liberates nitrogen gas.This inflates the air bag within 50 milliseconds.The gases are then released through several exhaust ports, allowing deflation within 2 seconds.Air bag gases comprise nitrogen (96%), small amounts of carbon dioxide (3%), and miscellaneous gases and particulates (1%).Talcum powder is often used in packaging and released with air bag inflation along with sodium hydroxide and sodium carbonate.l, 2Several types of cutaneous lesions have been reported to be caused by air bag deployment; these include erythema, abrasions, burns, and contusions.Lesions occur more frequently with the untethered
Gaucher disease. Current issues in diagnosis and treatment. NIH Technology Assessment Panel on Gaucher Disease
Journal: JAMA (1996)

To provide physicians with a responsible assessment of the diagnosis and treatment of Gaucher disease.A nonfederal, nonadvocate, 14-member panel representing the fields of pediatrics, obstetrics and gynecology, genetics, endocrinology, molecular biology, internal medicine, and biostatistics. In addition, 30 experts in genetics, pediatrics, neurology, obstetrics and gynecology, orthopedics, hematology, genetic counseling, clinical pathology, and epidemiology presented data to the panel and a conference audience of 230 during a 1 1/2 public session. Questions and statements from conference attendees were considered during the open session. Closed deliberations by the panel occurred during the remainder of the second day and the morning of the third.The literature was searched through MEDLINE, and an extensive bibliography of references was provided to the panel and the conference audience. Experts prepared abstracts with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience.The panel, answering predefined questions, developed their conclusions based on the scientific evidence presented in open forum and on the scientific literature. The panel composed a draft statement that was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after the conference.Despite the success of enzyme therapy, treatment is limited by the cost of the agent. This makes it imperative to determine the lowest effective initial and maintenance doses, to define the appropriate clinical indications for treatment, and to establish uniform methods for optimize outcome assessment. The value of treatment for asymptomatic individuals has not been determined. General population screening for affected individuals and for carriers is not appropriate at this time. As a prototype for all rare diseases, the plight of patients with Gaucher disease raises difficult financial and ethical issues, which we as a society must address.
Manuali Hoepli. Soccorsi d'Urgenza.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal