tbuckley/cabot-search huggingface dataset:
From the Centers for Disease Control and Prevention. Progress toward poliomyelitis eradication--South East Asia region, 1988-1994
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Match March
Authors: William E. Golden
Journal: JAMA (1980)

ON WEDNESDAY of this week, nearly 16,000 envelopes were anxiously opened; their contents spelled the future for the entire graduating class of this nation's medical education system. Celebrations and commiserations began forthwith: the 1979-1980 National Residents Matching Program (NRMP) had come to its long-awaited climax. Attaining a first-year residency position has become a lengthy project requiring planning, social ingenuity, and, frequently, a fair amount of money. With the exception of some subspecialty programs the days of individual students seeking private agreements with house staff programs ended 28 years ago with the creation of the NRMP. The selection process was computerized to avoid thousands of students trying to gain the early favors of program directors before all desirable house staff positions were filled. The expansion of medical school enrollment during the 1970s and the relative stability in the number of first-year residency positions now exert pressures on the system that make
Transgenic Approaches for Modifying the Mammary Gland to Produce Therapeutic Proteins
Authors: Donato Romagnolo, Richard P. DiAugustine
Journal: Environmental Health Perspectives (1994)

Bioengineering of the mammary gland to produce proteins of therapeutic and industrial value is the result of extensive investigation of the physiology of the mammary gland and the ability to generate transgenic animals. Targeting the expression of heterologous proteins to mammary tissue requires a thorough understanding of the biochemical events that coordinate growth and differentiation of the mammary gland and of the hormonal and developmental regulation of expression of milk protein genes. The characterization of mammary-specific promoter regions in milk protein genes and knowledge of the mechanisms that confer integration site-independent expression of transgenes have significantly contributed to modifying the mammary gland to produce heterologous proteins of therapeutic interest. The generation of large transgenic farm animals provides the opportunity for large-scale production of proteins in milk that have a therapeutic value but are naturally present at low concentrations in biological fluids. Transgenic mammary epithelial cells offer a versatile research model in biomedical, environmental health, and neonatal toxicology research.
Comparison of the appropriateness of coronary angiography and coronary artery bypass graft surgery between Canada and New York State
Authors: E. A. McGlynn
Journal: JAMA (1994)

<h3>Objective.</h3> —To compare the appropriateness of coronary angiography and coronary artery bypass graft (CABG) use between the United States and Canada. <h3>Design.</h3> —Retrospective randomized medical record review. <h3>Setting.</h3> —All hospitals performing coronary angiography and/or CABG surgery in two Canadian provinces (Ontario and British Columbia); in New York State, 15 randomly selected hospitals that provide coronary angiography and 15 randomly selected hospitals that provide CABG surgery. <h3>Patients.</h3> —All patients were randomly selected. For coronary angiography, 533 patients in Canada and 1333 patients in New York were selected; for CABG, 556 patients in Canada and 1336 patients in New York were selected. <h3>Main Outcome Measures.</h3> —Percentage of patients in each country who had coronary angiography or CABG for necessary, appropriate, uncertain, or inappropriate indications as rated by criteria developed separately in each country and the complications of those procedures. <h3>Results.</h3> —For coronary angiography, 9% of Canadian cases and 10% of New York cases were rated inappropriate using Canadian criteria compared with 5% and 4%, respectively, using US criteria. For CABG, 4% of Canadian cases and 6% of New York cases were rated inappropriate by Canadian criteria compared with 3% and 2%, respectively, using US criteria. A lower proportion of procedures were performed on persons aged 75 years or older in Canada than in New York for both coronary angiography (5% vs 11%;<i>P</i>&lt;.001) and CABG (6% vs 14%;<i>P</i>&lt;.001). Women were also represented in lower proportions among angiography cases in Canada than in New York (28% vs 35%;<i>P</i>=.023). Canadian patients with left main coronary disease waited significantly longer between angiography and CABG than did New York patients (<i>P</i>&lt;.0001). <h3>Conclusions.</h3> —Rates of inappropriate use of cardiac procedures were low in Canada and New York, which suggests that the regionalization of cardiac procedures that characterizes both health care systems contributes to better clinical decision making. Differences in the use of cardiac procedures among the elderly in the two countries merits further comparative examination. (<i>JAMA</i>. 1994;272:934-940)
MISCELLANY.
Authors: Chr. Fenger.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
C6
Authors: Michael F. Hartshorne, John M. Bauman, Robert J. Telepak, Robert D. Karl, Michael A. Cawthon, William H. Howard, Stephen R. Bunker
Journal: Clinical Nuclear Medicine (1984)

Hartshorne, Michael F.; Bauman, John M.; Telepak, Robert J.; Karl, Robert D. Jr.; Cawthon, Michael A.; Howard, William H. III; Bunker, Stephen R. Author Information
Surgery, Its Principles and Practice, by Various Authors.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Boxing
Authors: Albert F. Peterman
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The report of the Council on Scientific Affairs concerning brain injury in boxing completely misses the point, as both Dr Lundberg and Dr Van Allen mentioned in their editorials (1982; 249:250), namely, that of chronic brain damage. As the senior neurologist in a state that not only encourages boxing matches but even has a boxing program at its major university, I hasten to support the editorial opinion that boxing is, indeed, an obscenity and should be banned from any kind of civilized society. I was briefly appointed to the medical advisory board of the state some years ago, solely for the purpose of certifying medical fitness of a well-known boxer before a controversial bout to be held in Nevada. I refused to do this and have not been a member of the medical advisory board since. I suspect that there will be a deluge of letters both supportive of and
Carboplatin & gemcitabine repeating doublet in recurrent breast cancer
Authors: R. A. Nagourney, J. Link, B. Sommers, W. Lyons, J. Blitzer, S. Hager, M. Flam
Journal: Journal of Clinical Oncology (2004)

851 Background: We previously reported a 50% objective response rate for the Cisplatin (Cis) & Gemcitabine (G) doublet in recurrent breast cancer (BC) (Nagourney, RA. J Clin Oncol, 2000). Our comparative studies in human tumors have shown similar degrees of synergy for Cis & G and Carboplatin (Carbo) & G (Evans SS, Proc ASCO, 2001). To examine the activity and tolerance of Carbo & G as a repeating doublet, a Phase II trial in recurrent BC was undertaken. Methods: Patients with 1st or 2nd relapse, measurable BC, performance status ≤ 2 and no known brain metastases were eligible after signing informed consent. To approximate the original Cis & G doublet, patients received Carbo AUC = 2.0 (Calvert) & G @ 800 mg/m2 both given days 1&8 Q21 day. Growth factors were allowed. Results: By December 2003, 12 patients were accrued with 10 evaluable and 2 excluded for brain metastases detected at cycle I. Toxicities, primarily hematologic, were manageable with scheduled dose reductions. Per patient, there were 6/10 (60%) Gr 3/4 neutropenia; 4/10 (40%) Gr 3 /4 thrombocytopenia & 2/10 (20%) Gr 3/4 anemia. There were no Gr 3/4 alopecia, neuropathies or treatment related deaths. Responses were observed in 5/10 patients (50%) with 1 CR (10%); 4 PR (40%); 2 stable & 3 disease progressions. Median time to progression was 5 months (range 2–20 months). Conclusions: Carbo & G is active in recurrent BC. While the preponderance of heavily pre-treated patients in the original Cis & G study make direct comparisons problematic, comparable degrees of activity have been observed, thus far. Appropriately adjusted Carbo doses (AUC = 2) can be safely administered with G in the repeating doublet schedule. Platinum salt & G therapies, Cis or Carbo-based, offer attractive options for recurrent BC. Future studies will help to define the optimal drug and dose schedule. Supported by a grant from Eli Lilly & Co. Indianapolis, Indiana. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Eli Lilly & Co. Eli Lilly & Co.
Parotid Tumor and Thyroid Cancer
Authors: Frank O. Becker
Journal: JAMA (1975)

THE OCCURRENCE of thyroid neoplasia following thymic or tonsillar irradiation in infancy or childhood has been well reported.<sup>1</sup>The role of head and neck irradiation in childhood in the development of salivary gland neoplasms has been suggested previously.<sup>1</sup>We recently treated two patients who had received tonsillar irradiation in childhood and subsequently were found to have the simultaneous occurrence of a thyroid carcinoma and a parotid neoplasm. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 26-year-old man saw his physician in March 1974, for an unrelated complaint. At that time, a mass was easily seen at the angle of the left mandible. The patient stated that it had been present for two to three years, but had not increased in size during this period. The additional finding of bilateral cervical adenopathy prompted referral of the patient to us for therapy. The patient denied any symptoms referable to the neck, including
Cancer Rehabilitation
Authors: S J Mellette
Journal: JNCI Journal of the National Cancer Institute (1993)

An important trend in cancer treatment is an increasing emphasis on the overall outcome, not just on survival or disease-free interval, but also on the functional status and the quality of life of the survivor. Measuring the quality of life as a part of a clinical protocol is not enough. Measures must be aimed at facilitating optimal function and life satisfaction for the patient treated for cancer. The rehabilitation techniques used to enhance the life of the survivor need to be subjected to the same sort of scientific rigor required for other kinds of treatment. To develop data on rehabilitation parameters, we must create and utilize standardized and reliable evaluation techniques and instruments. These evaluation practices can then be utilized in clinical trials, both to assess the effectiveness of the rehabilitation techniques themselves and also to determine the effect of specific antitumor treatments on the patient's physical and psychosocial function. An organized multidisciplinary cancer rehabilitation program as a part of clinical and research facilities may be helpful. The important concept for all of us involved with the care of cancer patients is that of conveying our concern, not only for their survival, but for their function--physical, emotional, social, and vocational.
Many children develop permanent hearing impairment even after neonatal screening
Journal: BMJ (2001)

Meningitis in infancy leads to developmental disabilitiesChildren who have meningitis in infancy have a 10-fold increase in the risk of developing permanent severe or moderate disabilities.Bedford et al (p 533) followed up 1717 children aged 5 years who had had meningitis.General practitioners and parents completed questionnaires about the health and development of 1584 children who had had meningitis and 1391 control children.Those in the meningitis group were more likely to have subtle deficits, such as middle ear disease and visual and behavioural problems.There was considerable variation in outcome depending on the age at infection and the causative organism.All children who have had meningitis should be carefully assessed. Post-traumatic stress disorder is a valid and useful diagnosisPost-traumatic stress disorder is a valid and useful diagnosis but it is not the only psychiatric response to trauma.The disorder is associated with high rates of psychiatric comorbidity and impaired social and occupational functioning and has a prevalence of 1%-7.8% in the general population.Mezey and Robbins (p 561) argue that the diagnosis of post-traumatic stress disorder is important for both patients and doctors and that it can be differentiated from other psychiatric diagnoses by biochemical, neuroanatomical, and phenomenological characteristics.Any concerns about the diagnosis in victims of chronic and lifelong trauma could be resolved by further refining the diagnostic criteria.
Comparison of single-dose vs one-week course of metronidazole for symptomatic bacterial vaginosis
Authors: J. Swedberg
Journal: JAMA (1985)

In a prospective, single-blind, randomized study, a single 2-g dose of metronidazole was compared with a seven-day course of 500 mg given twice daily in the treatment of symptomatic vaginal discharge associated with<i>Gardnerella vaginalis</i>. Based on resolution of symptoms and on cultures negative for<i>G vaginalis</i>, 86% (40/46) of women treated with the single dose and 97% (35/36) of women treated with the seven-day course were considered cured at seven to ten days after treatment. Evaluation at 21 days after treatment, however, indicated that only 46% (16/34) of patients treated with the single 2-g dose were considered cured compared with 86% (26/30) of those treated with the seven-day course. Treatment of sexual contacts did not significantly improve cure rates in either group. (<i>JAMA</i>1985;254:1046-1049)
Therapeutics
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Impact of S-Li-M Criteria in Myeloma in a Real-Life Population: Patient &amp; Disease Characteristics, Treatment and Outcomes from the Australian and New Zealand Myeloma and Related Diseases Registry (MRDR)
Authors: Phoebe Joy Ho, Elizabeth M. Moore, Cameron Wellard, Hang Quach, Hilary Blacklock, Simon J Harrison, Emma-Jane McDonald, Zoe McQuilten, Erica M. Wood, Peter Mollee, Andrew Spencer
Journal: Blood (2020)
MYELOPROLIFERATIVE DISORDERS
Authors: JACOBO GHITIS
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 December 1969MYELOPROLIFERATIVE DISORDERSJACOBO GHITIS, M.D.JACOBO GHITIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-6-1216_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Dr. Glasser's and Dr. Walker's studies (1) do not support the all-embracing concept of myeloproliferative disorders. My experience (unpublished) in this area supports their conclusions. In 10 years of hematological work I have seen many patients with chronic myelogenous leukemia yet none with polycythemia vera and only one with myelofibrosis and myeloid metaplasia. It may be worthwhile to add, against the concept of lymphoproliferative syndrome, that lymphosarcoma and acute lymphoblastic leukemia are very common disorders here. Yet chronic lymphocytic leukemia is rare....Reference1. GLASSERWALKER RMRI: Transitions among the myeloproliferative disorders. Ann. Intern. Med. 71: 285, 1969. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Universidad del Valle Medical School Cali, Colombia, S.A. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1969Volume 71, Issue 6Page: 1216-1216KeywordsChronic lymphocytic leukemiaChronic myelogenous leukemiaHematology and oncologyMyeloproliferative disordersPolycythemia veraPrecursor cells Issue Published: 1 December 1969 PDF downloadLoading ...
Abstract 16197: Pedicled Vein Grafts in Coronary Surgery Exhibit Reduced Intimal Hyperplasia at 6 Months
Authors: Øystein Pettersen, Rune Wiseth, Knut Hegbom, Dag O Nordhaug
Journal: Circulation (2015)

Introduction: Less-than-optimal long-term patency of the saphenous vein is one of the main obstacles for the success of CABG. Harvesting saphenous veins including a pedicle of perivascular tissue has been proposed to improve graft patency rates and endothelial function. Hypothesis: We hypothesized that pedicled vein grafts would show less intimal hyperplasia at 6-month angiographic follow-up. Method: Sixty patients scheduled for first time elective on-pump CABG were randomized to conventional or pedicled vein harvesting. Exclusion criteria were insulin dependent diabetes mellitus, recent smoking or renal failure. Pedicled veins were harvested with perivascular tissue and conventional veins were skeletonized. All veins were distended manually to check for leakage and stored in heparinized blood and saline. At 6 months vein grafts were examined with Intravascular Ultrasound (IVUS) and Optical Coherence Tomography (OCT). Imaging analysis was performed by an external blinded Core-lab. Results: Fifty-four patients were available for follow-up. There were no significant differences in occlusion rates between the two groups. IVUS showed no significant difference in intima-media complex thickness (pedicled: n=28, mean 0.229 mm, SEM 0.011; conventional: n = 26, mean 0.235 mm, SEM 0.017). However, using OCT pedicled veins showed significantly less intimal thickness than conventional veins (pedicled: mean 0.270 mm, SEM 0.012; conventional: mean 0.358 mm, SEM 0.021; p&lt;0.001). In conventional veins higher perioperative flow was positively correlated to increased intimal thickness. Such a correlation was not found in pedicled grafts. The difference in response to flow was significant using a general linear model including an interaction term (adjusted R squared = 0.254, p&lt;0.018). Conclusion: Performing CABG using saphenous vein grafts harvested with a pedicle of perivascular tissue provides significantly less vein graft intimal hyperplasia at 6 months.
Hopelessness and suicidal behavior. An overview
Authors: A. T. Beck
Journal: JAMA (1975)

The relation of hopelessness to levels of depression and suicidal intent was explored both psychometrically and clinically. The results of an investigation of 384 suicide attempters support previous reports that hopelessness is the key variable linking depression to suicidal behavior. This finding has direct implications for the therapy of suicidal individuals. By focusing on reducing the sources of a patient's hopelessness, the professional may be able to alleviate suicidal crises more effectively than in the past. (<i>JAMA</i>234:1146-1149, 1975)
Errors in Intervention Cost Per Smoker
Authors: Don Rockey, Robert Rahimi
Journal: JAMA Internal Medicine (2015)

Jennifer S. Haas, MD, MSc; Jeffrey A. Linder, MD, MPH; Elyse R. Park, PhD, MPH; Irina Gonzalez, MD, TTS; Nancy A. Rigotti, MD; Elissa V. Klinger, ScM; Emily Z. Kontos, ScD; Alan M. Zaslavsky, PhD; Phyllis Brawarsky, MPH; Lucas X. Marinacci, BA; Stella St Hubert, AB; Eric W. Fleegler, MD, MPH; David R. Williams, PhD, MPH