tbuckley/cabot-search huggingface dataset:
Peroxidative Metabolism of Carcinogenic N-Arylhydroxamic Acids: Implications for Tumorigenesis
Authors: Danuta Malejka-Giganti, Clare L. Ritter
Journal: Environmental Health Perspectives (1994)

Peroxidative oxidations of chemical carcinogens including N-substituted aryl compounds could result in their metabolic activation because the products react with cellular molecules and lead to cytotoxicity, mutagenicity, and carcinogenicity.In vivo, peroxidative activities are chiefly of neutrophilic leukocyte origin.Neutrophils may be attracted to the site(s) of exposure to carcinogen and, via phagocytosis and respiratory burst, release oxidants that cat- alyze carcinogen activation and/or cause DNA damage.Our studies, presented herein, concern oxidations of carcinogenic N-arylhydroxamic acids, N-hydroxy-N-2-fluorenylacetamide (N-OH-2-FAA), and N-hydroxy-N-2-fluorenylbenzamide (N-OH-2-FBA), by enzymatic and chemical systems simulating those of neutrophils, myeloperoxidase and hydrogen peroxide (H202) ± halide, and hypohalous acid and halide at the physiologic concentra- tions (0.1 M Cl and/or 0.1 mM Br) and the pH (4-6.5) of phagocytosis.Studies also concern oxidations of the hydroxamic acids by rat peritoneal neutrophils stimulated to undergo respiratory burst and release myeloperoxidase in medium-containing 0.14 M Cl-± 0.1 mM Br-.The metabolites formed in the presence of exogenous H202 are consistent with two peroxidative mechanisms: one electron-oxidation to a radical that dismutates to equimolar 2-nitrosofluorene (2-NOF) and the ester of the respective hydroxamic acid and halide-dependent oxidative cleavage, especially efficient in the presence of Br, to equimolar 2-NOF and the respective acyl moiety. 2-NOF and the esters undergo further enzymatic and nonenzymatic conver- sions to unreactive products and/or may bind to cellular macromolecules.The results suggest that peroxidative metabolism of N-arylhydroxamic acids by neutrophils, yielding the potent direct mutagen 2-NOF and the electrophilic esters, occurs in vivo and is involved in the activation and thus local tumorigenicities of the hydroxamic acids at the site(s) of application.-Environ Health Perspect 1 02(Suppl 6):75-81 (1994) Key words: N-arylamines, N-arylhydroxamic acids, N-hydroxy-N-2-fluorenylacetamide, N-hydroxy-N-2-fluorenylbenzamide, peroxidative metabolism, one-electron oxidation, halide-dependent oxidation, metabolism by neutrophils Peroxidase-dependent Metabolism of N-Arylamines: Significance of Oxidizing Systems of Leukocyte Origin Because extrahepatic tissues are frequent targets of chemical induction of cancer and have low levels of cytochrome P450 monooxygenases, alternative systems involved in metabolic activation of carcinogens have been sought.Marnett et al. (1) discovered an enzyme system, prosta- glandin H synthase (PHS), containing cyclooxygenase and peroxidase activities that effected cooxidation of xenobiotics
Novel protein biomarkers in serum extracellular vesicles for the diagnosis of cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC)
Authors: Ainhoa Lapitz, Mikel Azkargorta, Colm O Rourke, Ander Arbelaiz, Adelaida La Casta, Mette Vesterhus, Piotr Milkiewicz, Raul Jimenez-Aguero, Ioana Riaño, Ana Landa, Cesar Ibarra, Javier Bustamante, María Jesús Perugorria, Luis Bujanda, Pedro Miguel Rodrigues, Jesper Andersen, Felix Elortza, Trine Folseraas, Tom Hemming Karlsen, Jesus M. Banales
Journal: Journal of Hepatology (2020)
Ostrich Fern Poisoning—New York and Western Canada, 1994
Journal: JAMA (1995)

Fiddleheads (crosiers) of the ostrich fern (Matteuccia struthiopteris) are a seasonal delicacy harvested commercially in the northeastern United States and in coastal provinces of Canada. Although some common ferns may be poisonous or carcinogenic, this species has been considered to be nontoxic. However, in May 1994, outbreaks of food poisoning were associated with eating raw or lightly cooked fiddlehead ferns in New York and western Canada. This report summarizes the investigations of these outbreaks.
NECROLOGY.
Authors: Henry O. Marcy
Journal: JAMA (1885)

light; it was of alkaline re-action; the cloudiness -disappeared upon the addition of nitric acid.This showed it to be due to phosphatic salts.Uric acid crystals were not to be found.On account of the uncertain light the test for uric acid by the murexid re-action was not shown.Nevertheless it was cer- '
Mir-128b Is a Potent Glucocorticoid Sensitizer in MLL-AF4 Acute Lymphocytic Leukemia Cells and Exerts Synergistic Effects with Mir- 221.
Authors: Ai Kotani, Daon Ha, Prakash Rao, James Hsieh, Diana Schotte, Monique L. den Boer, Scott Armstrong, Harvey F. Lodish
Journal: Blood (2008)
Going Out
Authors: M. Therese Southgate
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A REMEDY FOR THE ITCH
Authors: J. H. T.
Journal: JAMA (1960)

The infamous "skillet carryer" (a student who carries a tray of dressings and instruments during ward rounds ), surgeon, and plagiarist, John Browne (1642-1702), is not to be confused with Sir Thomas Browne, the famous 17th century surgeon whose<i>Religio Medici</i>is one of the great literary works of medicine. Thomas Browne was reluctant to publish his masterpiece. Browne, the plagiarist, was eager to print and unscrupulous in copying figures and anatomical drawings.<i>A Compleat Treatise of the Muscles, As they appear in Humane Body And arise in Dissection</i>, By Browne (1681)<sup>1</sup>was an outright steal of M[ill]ΣKOTOMIA:<i>Or, The Anatomical Administration Of all the Muscles Of an Humane Body, As they arise in Dissection</i>by William Molins, published in 1648. Browne's monograph went through 10 editions. One can draw no other conclusion than that Browne published for vain glory and not because of a desire to disseminate worthwhile new
Acyclovir treatment of herpes zoster infections. Use in children undergoing bone marrow transplantation
Authors: F. T. Serota
Journal: JAMA (1982)

Three patients in whom herpes zoster infections developed following bone marrow transplantation were treated with acyclovir. The patients experienced pain relief within 24 hours of starting treatment. The progression of their skin lesions halted within 1, 2, and 4 days of therapy, respectively, and healed completely within two weeks of therapy. Pharmacokinetic studies indicated that acyclovir plasma concentration-time profiles approximated biexponential equations. The drug half-lives were 3.91, 3.83, and 3.40 hours, respectively. Acyclovir was not myelotoxic and may be helpful in aborting varicella-zoster virus infections in bone marrow transplant recipients. (<i>JAMA</i>1982;247:2132-2135)
Cramps
Authors: Robert B. Layzer, Lewis P. Rowland
Journal: New England Journal of Medicine (1971)

TWENTY years ago, Brian McArdle discovered a disorder of muscle-energy metabolism (later identified as phosphorylase deficiency) in a young man with exertional muscle cramps. This event cast a certain glamor on the humdrum muscle cramp, and there has since been widespread medical attention to the symptom. Most patients who complain of cramps do not suffer from metabolic muscle disease, and there are so many other causes of cramps, spasms and stiffness that the subject has become confusing. In this survey we hope to provide an orderly basis for understanding the different ways in which cramps occur, recognizing that there are . . .
Interstitial Lung Disease: A Diagnostic Approach: Are CT Scan and Lung Biopsy Indicated in Every Patient?
Authors: Ganesh Raghu
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Interstitial Lung Disease: A Diagnostic Approach: Are CT Scan and Lung Biopsy Indicated in Every Patient?." American Journal of Respiratory and Critical Care Medicine, 151(3_pt_1), pp. 909–914
Pneumatosis Intestinalis
Authors: Stephen N. Martyak
Journal: JAMA (1976)

AS MORE experience is gained with jejunoileal bypass, more unanticipated complications are being discovered. A complication not yet reported is pneumatosis intestinalis in the defunctionalized small-bowel segment. This complication occurred in one patient in our series. <h3>Report of a Case</h3> A 46-year-old man weighing 154.5 kg (340 lb) underwent jejunoileal bypass for morbid obesity. He had prior episodes of severe cardiopulmonary failure. No endocrine abnormalities were discovered during preoperative evaluation. Upper gastrointestinal and small-bowel roentgenographic series, barium enema examination, and oral cholecystogram were normal. After treatment of the cardiac and pulmonary failure with digitalis, diuretics, and respirator therapy, the patient underwent a jejunoileal bypass with 35.5 cm of jejunum, anastomosed end-to-end to the terminal 10 cm of ileum. The defunctionalized small-bowel segment was closed proximally and fixed to the root of the small-bowel mesentery, and the distal segment anastomosed end-to-side to the sigmoid colon. The postoperative course was complicated by
516P Utility of colonoscopy in diagnosing familial adenomatous polyposis (FAP) among patients (pts) with desmoid tumors (DT)
Authors: Z. Zhang, M. Teo, K.C. Soo, M.H. Tan, A.Y-F. Chung, W.L. Goh, S. Sathiyamoorthy, K. Sittampalam, J. Teh, F. Chin, S-T. Li, J. Ngeow, M. Farid, R. Quek
Journal: Annals of Oncology (2016)
AMERICAN RESEARCH AND GERMAN REVIEWERS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RHEUMATOLOGY INDEX
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A safety study of trebananib (AMG 386) and abiraterone in metastatic castration-resistant prostate cancer (mCRPC).
Authors: Michelle A. Ojemuyiwa, Fatima Karzai, Avani Atul Shah, Marc Robert Theoret, Nancy Harold, Guinevere Chun, William Douglas Figg, Andrea Borghese Apolo, Douglas K. Price, Ravi Amrit Madan, James L. Gulley, William L. Dahut
Journal: Journal of Clinical Oncology (2014)

5074 Background: Trebananib is an angiopeptide angiopoietin1/2 peptibody antagonist . Androgens stimulate expression of VEGF via activation of hypoxia inducible factor-a (HIFa). Androgen deprivation therapy (ADT) is associated with lower HIF1a gene expression in prostate cancer tissue. Dual targeting of the androgen and angiogenic axis represents a potential synergistic anti-angiogenic therapeutic approach in mCRPC. In this preliminary safety study we hypothesize that trebananib in combination with abiraterone will have a favorable tolerability and efficacy profile. Methods: Patients(pts) with mCRPC were treated with abiraterone 1000mg daily and prednisone 5 mg twice daily. Trebananib was administered intravenously every week, in escalating doses from 15mg/kg to 30mg/kg on days 1, 8, 15 and 22 every 28-days. Results: A total of 9 pts were enrolled. Three of nine pts had prior chemotherapy. The median age was 63.8 (63-71yrs). No dose limiting toxicities were observed. The most common grade ≥2 toxicities included limb edema (3/9), hyperglycemia (1/9), gastrointestinal (2/9), fatigue (2/9), hypertension (1/9), confusion (1/9), weight gain (1/9) and insomnia (2/9). 5/9 of pts had an overall PSA decline of >30%. 8/9 pts were evaluable for response. Pts previously treated with chemotherapy were on study for 1and 3 months, respectively. Chemotherapy-naïve pts were treated for 1, 6, 9, 10, 10, and 21 months, respectively. Conclusions: Trebananib in combination with abiraterone is well tolerated and displayed an acceptable safety profile in pts with mCRPC. Based on this safety data a randomized phase II study randomizing chemotherapy-naïve mCRPC pts to either abiraterone/prednisone plus AMG 386 at 30mg/kg or abiraterone/prednisone is currently accruing at the NCI. Clinical trial information: NCT01553188.
Glycosuria of Pregnancy
Authors: J. Fine
Journal: BMJ (1967)

Dukes9s classification for colorectal cancer is simple, and correlates well with survival. This study assessed whether the principles of Dukes9s classification applied to gastric cancer resulted in the separation of prognostically useful groups. The cumulative survival curves determined by Dukes9s, Astler-Coller9s (another classification for colorectal cancer), and the Japanese classification for gastric cancer were evaluated using 476 curatively treated patients with gastric cancer. Of the three staging systems, both Dukes9s and the Japanese classifications showed a step-wise relationship between the stage of the tumour and the survival of patients. The prognostic value of Dukes9s classification was reinforced when Dukes9s C cases were subdivided according to the number of positive nodes (1-6 v &gt; or = 7) or the level of positive nodes (n1 v n2,n3) but not when the subdivision was made according to the depth of wall invasion. A modified Dukes9s classification in which Dukes9s cases are subdivided according to the number of metastatic nodes (Dukes9s Ca = 1-6 nodes, Dukes9s Cb &gt; 6 nodes) could be both simply and accurately applied to gastric cancer.
The Pathology, Diagnosis and Treatment of the Diseases of Women.
Authors: None E. W. A.
Journal: JAMA (1883)

The fourth edition of Hewitt's " Diseases of Women," having been rewritten to a large extent, now appears under the auspices of Harry Marion-Sims, of New York, with various [ bracketed ] annotations by the editor scattered through its pages. This is a form of revision having certain advantages in the direction of clearness and completeness. The items of difference in the opinions of the author and his editor or reviser are thus sharply defined, so that reference is assisted in the casual use of the book. This is the form of annotation employed in the revised " Holmes's Surgery," Hewitt's treatise, in its latest as in its earlier form, lays great stress upon the factor of impaired nutrition in the production of the various deformities and malpositions of the uterus, which he believes to be the usual cause of most complaints in gynæcology. " Chronic starvation " thus underlies the writer's theories of uterine pathology,
THE NORDIC FOOTBALL INJURY AUDIT: HIGHER INJURY RATES FOR PROFESSIONAL FOOTBALL CLUBS WITH THIRD-GENERATION ARTIFICIAL TURF AT THEIR HOME VENUE
Authors: K Kristenson, J Bjørneboe, M Waldén, TE Andersen, J Ekstrand, M Hägglund
Journal: British Journal of Sports Medicine (2014)

Background Studies generally report similar acute injury rates when playing football on artificial turf (AT) compared with natural grass (NG), but the association between playing surface and overuse injury rates is rarely reported. Objective To compare (i) acute injury rates in professional football played on AT and NG at the individual player level, and (ii) acute and overuse injury rates at the club level between clubs having AT at their home venue and clubs with NG. Design Prospective cohort study. Setting Male professional football. Participants All clubs in the Swedish and Norwegian first leagues in seasons 2010 and 2011 were invited to participate. 32/37 clubs participated (AT clubs, n=11; NG clubs, n=21), including 1044 players. Risk factor assessment Football exposure and injuries on AT vs. NG. Clubs were further defined as AT club or NG club according to the surface installed at their home venue. Main outcome measurements Injury rate expressed as the number of time loss injuries/1000 hours and reported as a rate ratio (RR) with 99% confidence interval. Results No differences were found in acute injury rates on AT and NG during match play (RR 0.98, 0.79–1.22) or training (RR 1.14, 0.86–1.50) at individual player level. At club level AT clubs had higher acute training injury rate (RR 1.31, 1.04–1.63), and overuse injury rate (RR 1.38, 1.14–1.65) compared with NG clubs. Conclusions Consistent with previous research, no differences were seen in acute injury rates when playing on AT compared with NG. However, clubs with AT at their home venue had higher rates of acute training injury and overuse injury compared with clubs that play home matches on NG.
Dr. Ross Clayton, MacCardle 1901–1964
Journal: JNCI Journal of the National Cancer Institute (1964)

Dr. Ross Clayton, MacCardle 1901–1964 JNCI: Journal of the National Cancer Institute, Volume 33, Issue 4, October 1964, Pages 593–597, https://doi.org/10.1093/jnci/33.4.593 Published: 01 October 1964
NEWER SIGNIFICANCE OF VENEREAL DISEASE.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Schistosoma Mansoni.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exaggerated radiation-induced fibrosis in patients with systemic sclerosis
Authors: J. Varga
Journal: JAMA (1991)

Four patients with stable systemic sclerosis and limited skin involvement received radiation for the treatment of solid malignant neoplasms. Following localized irradiation, each patient developed an exaggerated cutaneous and internal fibrotic reaction in the irradiated areas. The surface area of fibrosis extended beyond the radiation portals employed, and the fibrotic process was poorly responsive to antifibrotic therapy. Three of the patients died of complications caused by fibrous encasement of internal organs. The extent and severity of postradiation fibrosis in these patients was distinctly unusual. These observations suggest that patients with systemic sclerosis are particularly susceptible to developing excessive radiation-induced fibrosis. (<i>JAMA</i>. 1991;265:3292-3295)
Machine learning identifies histologic features associated with regression of cirrhosis in treatment for chronic hepatitis B
Authors: Dinkar Juyal, Chinmay Shukla, Harsha Pokkalla, Amaro Taylor, Oscar Zevallos, Murray Resnick, Michael Montalto, Andrew Beck, Ilan Wapinski, Patrick Marcellin, John F. Flaherty, Vithika Suri, Anuj Gaggar, Mani Subramanian, Ira Jacobson, Edward Gane, Maria Buti
Journal: Journal of Hepatology (2020)