tbuckley/cabot-search huggingface dataset:
A diagnostic model for diagnosing chlamydial infection
Authors: D. G. Addiss
Journal: JAMA (1991)

<h3>In Reply.—</h3> Dr Graham objects to my suggestion of "careful and serial" monitoring of liver functions, suggesting that this wording places an unnecessary burden on the prescribing physician and indeed may make him or her more liable to litigation. As part of my conclusion, I stated, "We would be well advised, then, to monitor liver functions (especially the transaminases) carefully and serially in any patient undergoing long-term NSAID therapy." I further recommended baseline liver profile studies in any individual suspected to be at risk for hepatic injury (as briefly outlined, alcohol or other drug abusers, those debilitated or immunocompromised, those testing positive for the human immunodeficiency virus or at risk for the acquired immunodeficiency virus, those with a history of foreign travel, those exposed to toxic industrial products or hepatitis, those receiving blood transfusions, or those with a "chronic pain" problem with attendant "overmedication," either "self" or iatrogenic. Dr Graham
General Motors Foundation Names 1994 Laureates
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article General Motors Foundation Names 1994 Laureates Get access JNCI: Journal of the National Cancer Institute, Volume 86, Issue 13, 6 July 1994, Page 967, https://doi.org/10.1093/jnci/86.13.967 Published: 06 July 1994
PRESERVATION OF THE ANTISCORBUTIC VITAMIN
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Category Index
Journal: Hepatology (2014)

A non-invasive method for en 728 A pilot study to determine t 746 Acetaminophen (APAP)-induced 724 Activation of TGR5 in the br 10 Acute Liver Decompensation F 720 Acute Liver Failure related 727 Alginate biocompatibility fo 716 Alpha fetoprotein: A biomark 722 Ambient temperature short-te 735 Arterial ammonia concentrati 729 Assessment of adrenal functi 718 C/EBP homologous protein (CH 748 Characterization of Acute-on 719 Characterization of disease-742 Development and Validation o 714 Etiology, Clinical Features 740 Genome editing with Cas9 in 731 Granulocyte colony stimulati 747 Granulocyte-colony stimulati 739 Hepatocyte Krüppel-Like-Fac 736 Higher thyroid-stimulating h 734 Hyperammonaemia and systemic 715 Impaired Neutrophil Function 730 Impaired monocyte and macrop 737 Implanted human bone mesench 717 Improved survival of hepatoc 721 Inclusion of Admission Red C 744 Increased CD11b+CD163+ macro 750 Increased neutrophil actin p 738 Incremental dose model ident 11 LDH in the determination of 732 Liver failure determines the 733 Micro RNAs miR-106a, miR-122 751 Microglia activation during 12 Pre-existing liver diseases 745 Predicting Progression from 713 Secretory Leukocyte Protease 741 TNF-α Induces Receptor Inte 725 The Mortality of Acute-on-Ch 712 The Safety of Therapeutic Pl 723 The Usefulness of Prognostic 726 The clinical and immunologic 749 Therapeutic misadventure wit 24 Traditional prognostic facto 743 Biliary Physiology, Transport,
Medical News.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In time of change, USSR seeks to end tradition of extensive alcohol use by majority of citizens
Authors: T. F. Kirn
Journal: JAMA (1987)

"NYET, NYET," said Daniel J. Anderson, PhD, leaning over a small table, pounding his fist through the air above it. He was predicting the reaction of the visiting delegation of Soviet alcohol-abuse officials to an upcoming presentation of the Hazelden Foundation's (Center City, Minn) new model of "chemical health." Anderson, the foundation's president emeritus, was both dreading a contretemps and itching for a lively debate. As its name implies, the model is a blueprint for promoting healthy and responsible alcohol/chemical use by preventing abuse, responding to problems, and encouraging healthy life-styles. It works at two levels, both as a prescription for treating the alcohol/chemical abuser and as a rough outline for society-wide efforts, says Anderson (whose work in the alcoholism field was recognized a few weeks ago by the University of Minnesota, which presented him with an honorary doctorate). Anderson's Soviet guests, three members of the All-Union Voluntary Temperance Promotion
Woman's Auxiliary
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Ecology
Authors: Robert K. McLellan
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The recent Council Report<sup>1</sup>on clinical ecology repeats a mistake that has been made in position papers published by other medical societies. The report confuses criticism of a mode of medical practice (clinical ecology) with analysis of several clinical conditions. Does the Council on Scientific Affairs really mean to imply that chronic fatigue syndrome (CFS), sick building syndrome (SBS), and multiple chemical sensitivity syndrome (MCSS) are inventions of clinical ecology? Each of these syndromes is the target of serious research by a broad spectrum of medical and environmental scientists. Well-conducted surveys have suggested that more than 20% of office workers suffer from nonspecific, building-related complaints.<sup>2</sup>The World Health Organization made one of the first attempts to group these symptoms into one general definition of SBS.<sup>3</sup>Extensive research on the health effects of indoor air pollution has failed to identify a specific causative agent for
Medical students and medical school
Authors: H. K. Silver
Journal: JAMA (1982)

ON A BRIGHT morning in late August in the early 1980s, a senior member of a medical school faculty attended an orientation session being held for incoming freshmen medical students. It made him feel good when he looked around the large lecture hall and saw the eager, alert, enthusiastic, and excited men and women from various walks of life and a variety of educational backgrounds. When the dean of the medical school spoke to the new freshmen students and indicated that they would have to work harder than they ever had before, the Faculty Member could almost sense them saying, "That's OK! Let us at it. Medical school will be an exciting and rewarding experience and we're ready. We've been waiting for this for years." And when the dean talked about the obligations of medicine, what becoming a physician entailed, and some of the difficult problems with which they would
Diabetes
Authors: Elliott P. Joslin, Leo P. Krall, C. C. Bailey, Howard F. Root, Priscilla White, Alexander Marble
Journal: New England Journal of Medicine (1948)

THE following subjects are considered in this progress report on diabetes: statistics; diabetic acidosis and coma; the hyperglycemic action of highly purified alkaline phosphatase; convulsive states in diabetes; electrocardiographic changes; arteriosclerosis; pregnancy in diabetes; metabolism of carbohydrate and fat; the diabetes section of the United States Public Health Service; new rapid blood sugar tests; and alloxan diabetes.StatisticsVariations in diabetes mortality in different countries and even in the different states of the United States are so glaring as to arrest attention and demand explanation. Such a diversity of statistical data can be explained partly by different methods of recording . . .
Hospital Profiles
Authors: Lawrence R. Dame
Journal: JAMA (1966)

More than 1,000,000 Blue Cross records of hospital admissions, and the related hospital utilization by more than 6,000 Massachusetts doctors, were reviewed in the research study on utilization by the Medical Affairs Committee of the Massachusetts Blue Cross Board of Directors. From this activity came the concept of using widespread medical practice as a guide in the selection of cases for medical review. For the last five or six years the public has been— and is—concerned about the ever-increasing costs of hospital care. Specific segments of the public, including physicians, Blue Cross, and hospital administrators, have special interests in finding the answer to the question "What is<i>necessary</i>hospital care?" When the family provider relates this general financial concern to his own problem he often seeks out a medical-hospital insurance program. This loss of noseto-nose contact of the patient with his hospital costs and the transference of the immediate financial
Meaning of the downward trend in cardiovascular mortality
Authors: W. B. Kannel
Journal: JAMA (1982)

THE RECENT decline in deaths from coronary heart disease (CHD) and accelerated decline in cardiovascular mortality in general since 1968 have elicited great interest and speculation as to their cause.<sup>1</sup>The improvement has been attributed to possible impacts of medical advances, preventive measures, and changes in life-style. One unequivocal conclusion is that these diseases are not an inevitable consequence of aging or genetic makeup and can be prevented. Since the mid-1960s, there has been a substantial decline in mortality from cardiovascular disease. Age-adjusted cardiovascular death rates in the United States fell 25% in the decade ending in 1979, and the decline seems to be continuing through the present. This decline in cardiovascular mortality has also occurred in Canada and in some, but not all, of the industrialized countries of western Europe.<sup>2</sup> While the trend in cardiovascular mortality is encouraging, these diseases continue to rank first among the leading
Colorectal cancer chemotherapy: meta-analysis or large-scale trials?
Authors: B. Levin
Journal: JAMA (1988)

In this issue of<i>JAMA</i>, Buyse and colleagues<sup>1</sup>present a meta-analysis of adjuvant therapy for colorectal cancer. They have previously provided information about meta-analysis,<sup>2</sup>which is a new discipline that statistically combines and critically reviews the results of previous research. The purposes of meta-analysis include the following: (1) to increase statistical power for primary end points and for subgroups, (2) to resolve uncertainty when reports disagree, (3) to improve estimates of effect size, and (4) to raise and possibly answer questions not posed at the start of individual trials. In this comprehensive review, Buyse and coworkers<sup>1</sup>have assembled all randomized, controlled, clinical trials on adjuvant therapy for colorectal cancer published up to December 1986 in the English language. They excluded nonrandomized and "immature" trials and those using adjuvant liver perfusion. Among the 27 trials found, eight trials compared radio See also p 3571. therapy with (surgical) control
Blood Chemistry: Colorimetric Methods. For the General Practitioner; with Clinical Comments and Dietary Suggestions.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MICROCEPHALY
Authors: CLEMENS E. BENDA
Journal: American Journal of Psychiatry (1941)

Two cases have been presented which illustrate two types of pathology which may be encountered in low grade idiocy with microcephaly. The first case represents a developmental arrest with macrogyria and microgyria interna. In its degree of development, this brain corresponded to the brain of a six months fetus. The second case is one of microcephaly with cystic degeneration of the white matter. History and pathology indicate that the cystic degeneration was due to prolonged asphyxia at birth. Both cases showed micro-hydrocephaly and the difference between this condition and true hydrocephaly has been discussed.
Autoimmunity postulated in ear disorder
Authors: P. Gunby
Journal: JAMA (1978)

Some patients may have an autoimmune inner ear disorder similar to Menière's disease, say University of Iowa College of Medicine investigators, who have seen 18 such cases. Brian F. McCabe, MD, professor of otolaryngology and maxillofacial surgery, described a composite patient for the Lake Bluff conference: A 25-year-old man, previously in excellent health, awakes one morning with a feeling of fullness in the ears, unsteadiness, and tinnitus. His hearing begins to deteriorate and, despite antibiotic therapy, continues to do so. A month later he awakes with a complete paralysis of the right side of his face. This paralysis responds only slightly to steroid therapy. Extensive tests are done, with mostly normal results. He is given intensive therapy with oral dexamethasone and intravenous cyclophosphamide for eight to 30 months. His hearing gradually returns to about 70% of normal, the other ear problems subside, and the facial paralysis resolves. The Iowa City
Efficacy and safety of single agent (SA) or combination (CO) adjuvant chemotherapy (AC) in elderly patients with colon cancer: A Canadian cancer institute experience.
Authors: Christina Kim, Jennifer L. Spratlin, Sunita Ghosh, Dawn Elizabeth Armstrong, Karen E. Mulder
Journal: Journal of Clinical Oncology (2014)

581 Background: Although AC is recommended for colon cancer, the pattern of AC use in elderly patients (pts), the toxicity profile, &amp; survival benefit is unclear. We sought to (1)determine whether pts ≥ 65 years old with stage III colon cancer were being offered SA or CO AC; (2)evaluate the reason for selecting SA vs. CO AC; (3)evaluate the toxicity profile of SA and CO in the elderly; and (4)determine whether a survival benefit exists for elderly pts receiving CO AC. Methods: Pts ≥ 65 diagnosed with stage III colon cancer at the Cross Cancer Institute from 2004-2010 were identified from the cancer registry. A retrospective analysis of electronic and paper patient records was performed to identify baseline characteristics, AC protocols used, toxicity, dose intensity and survival. Results: 258 pts ≥ 65 years old were diagnosed and treated with AC from 2004-2010. Of these, 168 were treated with SA and 90 with CO AC. The most common reasons for choosing SA AC were patient preference (64%), comorbidities (10%), and lack of drug coverage by provincial formulary (15%). 93 pts ≥age 75 were treated with SA AC, whereas only 10 pts ≥ 75 were treated with CO AC. Multivariate analysis revealed that for each year above 65, the adjusted odds of receiving CO over SA AC decreased by 22%. The presence of cardiac comorbidities decreased the adjusted odds of receiving CO AC by 58%. 28% of pts treated with SA and 6% of those treated with CO AC had initial dose reductions, with most common reasons being comorbidities and age. 67%, 71%, and 29% received dose delays, reductions or drug discontinuation in the SA group, respectively. 72%, 58%, and 34% received dose delays, reductions or drug discontinuation in the CO group respectively, mostly due to hematologic toxicity. The 5 year OS was 73% in pts who received SA AC, compared to 84% in those who received CO AC. A competing risk analysis showed no difference in cancer-related deaths between the CO and SA AC groups. Conclusions: In elderly pts treated with AC for stage III colon cancer, SA AC is used more frequently than CO AC, based on age, comorbidities, and patient choice. Toxicity with CO AC in elderly pts is high, leading to decreased dose intensity. No survival benefit was seen with CO AC over SA AC.
Clinicopathological Conference: Diagnostic difficulties in a case of polypharmacy
Journal: BMJ (1977)

The fifteenth quarterly clinicopathological conference was held at the Royal College of Physicians of London on 29 July 1976. The conference was chaired by Professor Sheila Sherlock (1). She began by introducing Professor Jean-Pierre Benhamou (2), professor of gastroenterology at the Beaujon-Clichy Hospital, University of Paris, who was to open the discussion of the case. Professor Sherlock emphasised that this case had no great dénouement but was more a talking point for various aspects of hepatology, a review of the state of the art. Dr James Scott (3) presented the case, and Dr R Dick (4) described the radiological findings.
Nomenclature for mononucleosis syndromes
Authors: M. C. Jordan
Journal: JAMA (1975)

INFECTIOUS mononucleosis has fascinated clinicians, epidemiologists, and laboratory investigators for many years. Although the typical case is easily recognized, unusual manifestations or serious complications occur frequently enough to pose problems in diagnosis and management. For this reason, students of the disease have insisted that certain criteria be fulfilled before the term "infectious mononucleosis" is used in a given case. General agreement on the characteristic clinical and hematologic findings has prevailed, but controversy concerning the importance of the serum heterophil agglutination test continues.<sup>1-3</sup>On one side, many authors have referred to cases of apparent mononucleosis that lack the heterophil agglutinin as examples of "heterophil antibody-negative mononucleosis." Others have criticized this practice, reserving the term "infectious mononucleosis" for patients whose illness fulfills the "diagnostic triad" of clinical, hematologic, and serologic (positive heterophil-antibody) findings.<sup>1-3</sup>In light of recent information on the etiology of mononucleosis syndromes, these arguments are no longer necessary.
Editorial Board
Authors: Zuhair Ballas, Iowa City, Andrea Apter, Leonard Philadelphia, St Bacharier, Claus Louis, Joshua Boyce, Robert Bush, Javier Chinen, Raif Geha, Kyoto Japan, Carole Ober, David Peden, Chapel Hill, Harald Renz, Marburg Germany, Marc Rothenberg, Cincinnati Ohio, Hirohisa Saito, Tokyo Japan, Stephan Weidinger, Robert Wood, Immediate Past, Cezmi Akdis, Davos Switzerland, Paul Bryce, Mariana Castells, Mitchell Grayson, Columbus Ohio, Bruce Mazer, Ariel Munitz, Kari Nadeau, Bruce Bender, Pascal Chanez, Morton Cowan, San Francisco, Elizabeth Matsui, Katrina Allen, Peter Arkwright, Arthur Gelb, Los Angeles
Journal: Journal of Allergy and Clinical Immunology (2018)
The clinical investigation of lymphadenopathy in primary care practice
Authors: S. Greenfield
Journal: JAMA (1978)

ENLARGED lymph nodes occur in many conditions, either as a reaction to a local inflammatory process or associated with a systemic disease whose central focus is not in the lymph system. In some patients enlarged nodes are the initial or the most prominent manifestation of whatever disease is present and are the starting point for investigation. The algorithm presented here develops guidelines for evaluation of lymph node enlargement of the primary or secondary type. <h3>Scope and Limitations</h3> This algorithm is designed to be applied only to adolescents and adults, because a different array of diseases underlies enlarged lymph nodes in infants and children. It does not include therapy for any of the conditions detected. Following the model of protocols or clinical algorithms for primary care, it does not include diagnostic evaluation of rare diseases. On the other hand, nonspecific findings are included to alert the reader to consider more remote