tbuckley/cabot-search huggingface dataset:
Abstract 68: Comparative transcriptome analysis of primary tumor and matched tumor thrombus reveals that coagulation cascades activation contributes to the venous metastases of osteosarcoma
Authors: Tao Ji, Yifei Wang, Yi Guo, Dasen Li, Haijie Liang, Tingting Ren, Wei Guo
Journal: Cancer Research (2019)

Abstract Comparative transcriptome analysis of primary tumor and matched tumor thrombus reveals that coagulation cascades activation contributes to the venous metastases of osteosarcoma Osteosarcoma is the most frequent malignant primary tumor of bone in children and adolescents with an approximately 5-year survival about 50-60%. Lung metastasis remains as the most challenging condition during treatment and follow-up, which has been regarded as the main reason for bottle neck of prognosis. Tumor thrombus is occasionally diagnosed in patients with malignant tumor. It usually exists during tumor angiogenesis associated with proliferation and metastasis. The presentation shows aggressive features and advanced stage of the disease. Tumor thrombus is associated with highly metastasis potential. Based on the evolution theory of tumor metastasis, tumor thrombus can be the intermediate phase between local invasion and distal metastasis. In order to investigate the underlying mechanism and identify candidate metastasis driver genes, we collected a set of high quality paired tumor tissue, both the primary site and corresponding tumor thrombus that were treated by thrombectomy. In this study, we present a large-scale transcriptome analysis, by RNA sequencing, of 4 patients diagnosed with large pelvic osteosarcoma with tumor thrombus. The dysregulated genes between primary site and thrombus suggested that the complement and coagulation cascades, focal adhesion and extracellular matrix receptor was correlated with the formation of tumor thrombus. Tissue factor was identified as a major marker in coagulation pathway activation. We also identified NOTCH2NL-NBPF1 fusion genes in all four patients. All of these findings broaden our knowledge of osteosarcoma thrombus and may also contribute to the novel mechanism of metastasis in osteosarcoma. Citation Format: Tao Ji, Yifei Wang, Yi Guo, Dasen Li, Haijie Liang, Tingting Ren, Wei Guo. Comparative transcriptome analysis of primary tumor and matched tumor thrombus reveals that coagulation cascades activation contributes to the venous metastases of osteosarcoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 68.
Balloon angioplasty in coarctation: Should management differ in children and adults? Ronald Walhout, Jaco Lekkerkerker, Jan Koerselman, Sjef M. P. G. Ernst, Wieben Jaarsma, Paul Hutter, Thijs H. W. M. Plokker, Erik J. Meijboom. Heart Lung Center Utrecht, University Medical Center, Utrecht, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Adriamycin, A Decade of Experience: A Review and a Look to the Future
Journal: JNCI Journal of the National Cancer Institute (1984)

Adriamycin, A Decade of Experience: A Review and a Look to the Future Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 1, July 1984, Page 301, https://doi.org/10.1093/jnci/73.1.301 Published: 01 July 1984
THE MANIFESTATIONS OF RENAL DISUSE
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abnormal smears in pregnancy.
Journal: BMJ (1979)

their effects.3Initially the choice lies between oestrogens and orchidectomy.The trials of the Veterans Administration Urological Research Group have helped in showing both the value of a co-operative controlled trial conducted on a large number of patients and how hormone treatment should be used.45 These studies indicated that in patients with advanced local or metastatic disease such treatment was more effective than a placebo in giving symptomatic relief.Moreover, the risk of morbidity and death from cardiovascular complications of oestrogen treatment were shown to depend on the dose and they could be minimised by reducing the amount of diethylstilboestrol given from 5 to 1 mg daily.Nevertheless, no significant effect on overall survival could be detected with oestrogen, orchidectomy, or both combined, though the group made a case for prompt treatment since this was found to delay the onset of symptoms and objective evidence of progression.
Polycythemia Vera
Authors: George M. Pike
Journal: New England Journal of Medicine (1958)

CURRENTLY, polycythemia vera is considered by most hematologists to fall in the category of myeloproliferative disorders, a classification that also includes chronic myelocytic leukemia, erythremic myelosis, myelofibrosis, agnogenic myeloid metaplasia and megakaryocytic myelosis. In this group of diseases there is excessive production of all the bone-marrow elements, but the presenting clinical picture is determined by the predominance of one element. In polycythemia vera, also known as primary polycythemia, or erythremia, it is the excessive production of red blood cells with the attendant increase in blood volume and blood viscosity that produces the characteristic clinical and laboratory features of this disease, . . .
Brain: Journal of Neurology, London
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The clinical application of platelet transfusions
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lung Transplantation
Authors: Robert M Kotloff, Gabriel Thabut
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Section:ChooseTop of pageAbstract <<IndicationsIssues in Candidate Selec...Timing of ListingOrgan AllocationDonor Selection and Manag...Choice of ProcedureOutcomesCommon ComplicationsReferencesCITING ARTICLES
Calcium supplementation of the diet--I.
Authors: J. A. Kanis, R. Passmore
Journal: BMJ (1989)

the sternomastoid in spasmodic torticollis) can also be in- jected.'3'4 Nevertheless, large doses are required for treating bulky muscles and may cause systemic side effects besides stimulating antibody production.'5A further benefit has been for spastic dysphonia,'6 but less satisfactory results have been obtained with other small muscle groups such as in the hand and detrusor-sphincter abnormalities. 7
Corrigendum
Journal: BMJ (1935)

AJTURTTALvoice was completely restored.Then in January of this year she contracted another attack of bronchitis, after recovery from which she has only been able to whisper.An x-ray examination of the chest revealed some thickening at the hilum of the left lung, and it was concluded that the left recurrent nerve was caught in this mass, leading to paralysis of the left cord.Various treatments have been tried: diathermy, faradism, etc., none of which have influenced the condition.I have come to the conclusion
Handbook of Diseases of Infants and Children for Students and Practitioners.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The lupus anticoagulant in 14 male patients
Authors: C. C. Waddell
Journal: JAMA (1982)

Fourteen male patients examined for a prolonged partial thromboplastin time were found to have the lupus anticoagulant. In contrast to previous reports, there was no increased incidence of false-positive results of serological tests for syphilis. In only two patients was systemic lupus erythematosus confirmed, although two additional patients had a positive result of a test for antinuclear antibody. Other clinical diagnoses included peripheral vascular disease, cardiac disease, pulmonary disease, and schizophrenia. Prothrombin times were distinctly abnormal in only two patients. Bleeding was rarely encountered in these patients, including ten who underwent surgical procedures or some type of hemostatic challenge. Thrombocytopenia was not associated with bleeding but was present in two patients who had thrombotic events. (<i>JAMA</i>1982;248:2493-2495)
Relationship between Biotransformation and the Toxicity and Fate of Xenobiotic Chemicals in Fish
Authors: John J. Lech, John R. Bend
Journal: Environmental Health Perspectives (1980)

Many of the biotransformation reactions which have been described for xenobiotic substances in mammals have been demonstrated in fish in both in vitro and in vivo experiments. Several of these biotransformation reactions have been shown to occur in fish at rates which are sufficient to have significant effects on the toxicity and residue dynamics of selected chemicals. Inhibition of these reactions can lead to increased toxicity and bioaccumulation factors for certain chemicals. Several classes of compounds, including some polychlorinated biphenyls, are metabolized slowly, and their disposition in fish may not be influenced to any great extent by biotransformation. Metabolites of compounds which are biotransformed rapidly may appear in certain fish tissues, and in many instances these are not accounted for by conventional residue analysis methods. Microsomal mixed-function oxidases in several species of fish have been demonstrated to be induced by specific polycyclic aromatic hydrocarbons and by exposure of fish to crude oil. Induction of these enzymes in fish can result in both qualitative and quantitative differences in the metabolic disposition of xenobiotics to which fish are exposed.
Characteristics of Persons With Chronic Hepatitis B—San Francisco, California, 2006
Journal: JAMA (2007)

Chronic hepatitis B is the most common cause of cirrhosis and liver cancer worldwide. Approximately 45% of the world's population lives in regions where chronic hepatitis B virus (HBV) infection is endemic, including most of Asia and the Pacific Islands, Africa, and the Middle East. Nearly one fourth of the population of San Francisco was born in Asia and the Pacific Islands. In 2006, the San Francisco Department of Public Health (SFDPH) received reports consistent with probable chronic HBV infection for 2,238 persons. To characterize persons with reported confirmed chronic HBV infection in San Francisco in 2006, SFDPH collected additional data on a subset of 567 cases reported to the SFDPH chronic hepatitis B registry. Eighty-four percent of the persons were Asians/Pacific Islanders (A/PIs), 80% of whom were foreign born. Fewer than half had been referred to a gastroenterologist/hepatologist for evaluation at the time of reporting. Persons with chronic HBV infection can benefit from medical care by providers with expertise in viral hepatitis. In addition, close contacts of infected persons should be screened and offered vaccination if found to be susceptible to HBV infection. Culturally appropriate counseling for and follow-up of persons with chronic HBV infection and their contacts could help reduce the transmission of HBV infection.
Urinary ultrastructural findings in Fabry disease
Authors: S. M. Katz
Journal: JAMA (1977)

FABRY disease (angiokeratoma corporis diffusum universale) is a rare, sex-linked, familial disease associated with deficiency of the enzyme ceramide trihexosidase.<sup>1</sup>The lipid trihexosylceramide accumulates in the blood and several tissues. Lesions occur in the skin and visceral organs, particularly the heart, blood vessels, central nervous system, and kidneys. In the involved skin, dark red macules and papules contain dilated superficial capillaries. Lipid-laden vacuolated cells are a characteristic component of the visceral lesions. Typical ultrastructural "myelin" figures occur within the vacuoles of affected cells. These structures are composed of dense laminations of lipid material, resembling myelin sheaths. Using electron microscopy, we attempted to detect myelin figures in a urine sample from a patient with renal involvement by Fabry disease. <h3>Report of a Case</h3> A 48-year-old man was admitted to Hahnemann Medical College Hospital for evaluation of proteinuria and intermittent febrile episodes. Proteinuria was first noted at the age of 24
Correction
Authors: G St, R Mcgill, Hants Lymington
Journal: BMJ (1965)

MEDIBCAISHRNA,The spleen may remain palpable in glandular fever for ten weeks4 and it has also been recorded as persisting in a child aged 6 weeks for two months.5The spleen in glandular fever is very soft and very friable, and it is apparent that spontaneous rupture can occur and even more so that minimal injury may produce rupture.In the case report by Spink' spontaneous rupture was considered to be due mainly to pressure from within the abdomen and not from pressure without.The patient in that case had denied any injury.
Negative Results
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transmembrane Signals and Protooncogene Induction Evoked by Carcinogenic Metals and Prevented by Zinc
Authors: Jeffrey Bingham Smith, Lucinda Smith, Vivian Pijuan, Yingxin Zhuang, Yueh-Chu Chen
Journal: Environmental Health Perspectives (1994)

Cd2+ provokes an immediate production of inositol trisphosphate and the release of Ca2+ from internal stores in human fibroblasts and some other mammalian cells.Ni2+, Co2+, Fe2+, and Mn2+ evoke the release of stored Ca2+, but are less potent than Cd2+ (apparent Ko05 = 40 nM).Zn2+ and Cu2+ competitively inhibit Ca2+ release evoked by Cd2, without affecting Ca2+ release by hormones such as bradykinin.Zn2+ has the same appar- ent Ki value (80-90 nM) towards the five agonist metals, which suggests that the metals interact with the same site.Many other divalent cations neither released stored Ca2+ nor affected Cd2+-evoked Ca2+ release.The agonist metals appear to activate phospholipase C via a G protein rather than a tyrosine kinase.The production of reactive oxygen species is probably not involved in Ca2+ release by the metals.Cd2+ and other stimuli that raise cytosolic-free Ca2+ induce cyclic (AMP) production, apparently by activating a calmodulin-dependent adenylyl cyclase.We suggest that an orphan receptor mediates the hormonelike responses to Cd2+ and the other agonist metals.The receptor is referred to as an orphan because its physiological stimulus is unknown.Growth of the fibroblasts in high Zn2+ desensitizes them to the five agonist metals without affecting Ca2+ release by bradykinin or histamine.A several hour incubation in culture medium with normal Zn2+ fully restores responsiveness to the five active metals.Growth in high Zn2+ appears to repress the synthesis of the putative orphan receptor because inhibitors of RNA or protein synthesis, or asparagine-linked glycosylation, prevented the restoration of metal responsiveness.Experiments with lectins and neuraminidase support the view that a cell surface sialoprotein mediates Cd2+ responsiveness.Cd2+ evokes rapid changes in 132P] incorporation by certain proteins, as would be expected for the activation of a phospholipase C-coupled receptor.Cd2+ and the other metals that trigger hormonelike messenger production, also induce protooncogenes.These observations have revealed a new target for certain metals which is extraordinary with respect to metal potency and specificity.Additionally, the work reviewed here supports the view that certain metals can promote cell growth, which results in part from the fortu- itous induction of hormonelike signals.-
THE MEDICAL STUDY OF CRIMINALS.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tamsulosin and Ophthalmic Adverse Events After Cataract Surgery
Authors: Bruce I. Gaynes
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal