tbuckley/cabot-search huggingface dataset:
Blood ammonia
Authors: H. Brown
Journal: JAMA (1967)

Blood ammonia levels are determined by simple techniques with relatively inexpensive apparatus; therefore, most clinical laboratories should be able to make these measurements. The two principal diffusion methods for blood ammonia are those developed by Conway and Cooke<sup>1</sup>and Seligson and Seligson.<sup>2</sup>Both are based on the liberation of gaseous ammonia from ammonium salts by strong alkali, and absorption by an acid solution. The amount of ammonia absorbed is then determined by acid titration of colorimetrically by nesslerization. Ammonia concentrations are generally expressed in terms of micrograms per 100 ml of whole blood. Normal blood levels as a rule are less than 100 μg/100 ml. The determination is usually made immediately after the blood is drawn, but in practice it has been observed that blood drawn in vacuum tubes containing sodium edetate and refrigerated will remain stable for several hours. Ammonia is an essential metabolite. This is emphasized
mTORC2 promotes cell survival through c-Myc–dependent up-regulation of E2F1
Authors: Zhipeng Zou, Juan Chen, Anling Liu, Xuan Zhou, Qiancheng Song, Chunhong Jia, Zhenguo Chen, Jun Lin, Cuilan Yang, Ming Li, Yu Jiang, Xiaochun Bai
Journal: The Journal of Experimental Medicine (2015)
The early diagnosis of common bile duct obstruction using cholescintigraphy
Authors: L. Kaplun
Journal: JAMA (1985)

The technetium Tc 99m-labeled iminodiacetic acid cholescintigram is an extremely accurate examination for detecting early obstruction of the common bile duct in acutely ill patients suspected of having acute cholecystitis or possible obstruction days to years after cholecystectomy. The examination accurately detected common bile duct obstruction in 63 of 65 patients in these two diagnostic categories (positive predictive value, 96.9%). Sonographic evaluations in 43 of these patients failed to reveal ductal dilatation or other abnormality in 26 cases (false-negative rate, 63.4%), and was nondiagnostic because of overlying bowel gas in two cases. The success of the radionuclide examination is attributed to its ability to detect functional impedance to bile flow hours to days before anatomic ductal dilatation occurs, and occasionally even before the alkaline phosphatase level and other liver chemistry values suggest the presence of an obstruction. (<i>JAMA</i>1985;254:2431-2434)
AMA Auxiliary
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RAILROAD RATES.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevention of tuberculosis among tuberculin reactors: maximizing benefits, minimizing risks
Authors: G. W. Comstock
Journal: JAMA (1986)

Although an ounce of prevention may often be worth a pound of cure, there is an inherent and unfortunate tendency for prevention to be discouraging. Only in the midst of an epidemic are preventive efforts likely to be visible and dramatic. In most situations, something that is prevented is a nonevent. Individuals can hardly be expected to be aware of nonevents: these can be detected only by statistics. As a consequence, the benefits of prevention are more likely to appeal to our intellect than to our emotions. Bad effects, on the other hand, are usually readily recognized. Because they are likely to occur in close temporal association with the preventive procedure, they are perceived as resulting from that procedure even when they are merely coincidental. Their emotional effects can be severe, the more so because something bad happened when good was expected. Prevention of tuberculosis by giving isoniazid to persons
Mild Hypertension: Natural History and Management.
Journal: Annals of Internal Medicine (1980)

to concentrate on the recent advances in this field.The second part of the book is devoted to various papers on purine metabolic defects in immunode- ficiency.There is a good deal of clinical and biochemical detail here for those interested in purine nucleoside phosphorylase and adenosine deaminase deficiency.The third part consists of a series of papers on phagocytic defects which includes reviews, single case reports, hypotheses and technical innovations.This book is of interest to the connoisseur of lymphocyte and neutrophil defects, but it is too specialized and fragmented for those seeking a more general approach to the management and diagnosis of immunodeficiency.
The multiple risk factor intervention trial (MRFIT). A national study of primary prevention of coronary heart disease
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lambarene without Schweitzer
Authors: E. Schoenfeld
Journal: JAMA (1967)

The terminal illness of Albert Schweitzer was caused primarily by cerebral vascular insufficiency which manifested itself quite abruptly on August 28, 1965 with impairment of consciousness and of cerebral regulation of cardiac and respiratory function. During the preceding week he had seemed more fatigued than usual, with some unsteadiness on his feet. On the evening of August 29, because in his semi-comatose condition he was unable to take sufficient fluid by mouth, he was given an intravenous infusion of physiologically-balanced electrolyte solution, slowly through the night. For the most part thereafter he remained semi-comatose and bed-ridden, with transient periods of increased reactivity. Until September 3, he was able to take clear fluids, including beer (which he had asked for) in small amounts by mouth. His blood pressure was well maintained until nearly the end, and an electrocardiogram on 2 September revealed no evidence of myocardial infarction. On 3 September, his
Systematic Review: Family History in Risk Assessment for Common Diseases
Authors: Brenda J. Wilson
Journal: Annals of Internal Medicine (2009)

Background: The usefulness of routinely examining family history in primary care practice is uncertain. Purpose: To assess the beneficial and adverse effects of collecting family history in primary care populations; how well family history predicts individual disease risk; and how accurately patients report it. Data Sources: English-language studies in MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, and PsycINFO from 1995 to 2 March 2009. Study Selection: Two independent reviewers selected studies that met question-specific eligibility criteria. These included controlled and uncontrolled intervention studies of systematic family history collection and uptake of preventive interventions or adverse effects, longitudinal and cross-sectional studies that examined family history and disease frequency, and studies in which reported family history was validated against relatives' true disease status. Data Extraction: Information about study quality, setting, and findings was extracted using standardized protocols. Data Synthesis: Two uncontrolled studies provided insufficient evidence to assess whether querying about family history improves any outcomes. One randomized, controlled trial and 2 uncontrolled studies provided weak evidence that some patients experienced a reversible, short-term increase in anxiety associated with family history taking. In 41 studies, different family history definitions were associated with sensitivities of 0 to 0.51 and specificities of 0.66 to 1.00 for detection of disease risk, and 0 to 0.83 and 0.48 to 1.00, respectively, for detection of prevalent disease. Twenty-three studies suggested that absence of disease in relatives was more accurately reported than presence of disease and that reporting accuracy was higher for information related to first-degree relatives than more distant relatives. Limitation: Few studies were designed to address the specific questions of interest. Conclusion: Insufficient evidence evaluates how to collect family history information accurately in the primary care setting and the effects of taking family history on patient outcomes. Patients seem to correctly report the absence of disease in relatives more often than the presence of disease. Primary Funding Source: Agency for Healthcare Research and Quality.
Larotrectinib OK'd for Cancers with <i>TRK</i> Fusions
Journal: Cancer Discovery (2018)

Larotrectinib, a first-in-class TRK inhibitor, received accelerated approval for patients of all ages with solid tumors harboring NTRK fusions. It's the first tissue-agnostic marketing authorization for a targeted therapy and the first time a drug's initial approval has been site-independent.
Response
Authors: MARGARET R. SPITZ, JAN C. LIANG, SARA STROM, TERRI M. KING, T. C. HSU
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Response Get access MARGARET R. SPITZ, MARGARET R. SPITZ Search for other works by this author on: Oxford Academic PubMed Google Scholar JAN C. LIANG, JAN C. LIANG Search for other works by this author on: Oxford Academic PubMed Google Scholar SARA STROM, SARA STROM Search for other works by this author on: Oxford Academic PubMed Google Scholar TERRI M. KING, TERRI M. KING Search for other works by this author on: Oxford Academic PubMed Google Scholar T. C. HSU T. C. HSU Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 6, 15 March 1995, Page 458, https://doi.org/10.1093/jnci/87.6.458-a Published: 15 March 1995
Hypermobility
Authors: P. KLEMP
Journal: Annals of the Rheumatic Diseases (1997)

Leaders HypermobilityLast year marked the 80th anniversary of the first report of an association between hypermobility and articular manifestations by Finkelstein 1 and this year the 30th anniversary since the definitive description of the hypermobility syndrome (HMS) by Kirk, et al. 2 In the years since these landmark publications much has been written about hypermobility and reports can broadly be categorised as those dealing with its epidemiology, measurement, clinical associations, and the mechanisms causing them.Despite this our understanding of the role of hypermobility in articular and extra-articular manifestations remains confused.
Scuba Diving, Medical Supervision, Resuscitation on Sports Agenda
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accumulation of O 6 -Methylguanine in Human DNA after Therapeutic Exposure to Methylating Agents and Its Relationship with Biological Effects
Authors: Soterios A. Kyrtopoulos, Vassilis L. Souliotis, Christos Valavanis, Viki A. Boussiotis, Gerasimos A. Pangalis
Journal: Environmental Health Perspectives (1993)
Misspelled Name in: The Art of Pimping
Authors: Allyn Nakashima, Rosemarie Horsley, Robert Frey, Patricia Sweeney, J Weber, Patricia Fleming
Journal: JAMA (2009)

counseling and testing data system was begun, and 1 (Florida) began HIV reporting very recently and not enough time has elapsed to have adequate data for analysis.The year-to-year median percentage changes in total number of HIV tests during 1992 through 1996 for areas with and without HIV reporting were similar in magnitude and trend. 2 Although we showed no large declines in testing among MSM and other risk groups after HIV reporting, we agree with Arago ´n and Myers and Dr Woods and colleagues that trends in some subgroups-for example, in a small number of MSM concerned with reporting issues-could be hidden within the larger community of MSM.Because there will always be individuals concerned about these issues, we emphasized the importance of making anonymous testing available to promote knowledge of HIV status among at-risk people.The approval by the US Food and Drug Administration of home sample collection tests for HIV expands the availability of anonymous testing in all areas. 3oods et al also state that, except for New Jersey, we included only low-prevalence states.This is incorrect.Louisiana (acquired immunodeficiency syndrome [AIDS] rate of 33.7 per 100 000 in 1997) and Tennessee (25.1 per 100 000) have high AIDS incidence, comparable with their own state of California (29.8 per 100 000) 1 and are considered moderateprevalence states.Dr Solomon and colleagues are concerned that the study design was ecological and subject to the fallacy inherent in such studies, ie, that ecological correlations cannot be validly substituted for individual correlations.However, to demonstrate the impact of a policy change on a large population, ecological methods may be the most practical design.In an individual-level study, each individual's awareness of the change in policy would be determined.On a population basis, this would be a difficult study to conduct, especially if attitudes of high-risk persons were to be assessed.Although our study cannot distinguish between people who were aware ("exposed") and unaware ("not exposed") of the change in reporting policy, the important fact remains that no large changes in testing behavior were observed in the population.Our results are supported by a recent study of more than 2500 people in high-risk groups (MSM, IDUs, and attendees of sexually transmitted disease clinics) in 9 states. 4In this study, more than 60% of participants were unaware of their state's HIV reporting policy and, of those avoiding testing, only 2% stated that reporting was a main factor for not being tested. 4urthermore,
Angiotensin-Converting Enzyme: II. Pulmonary Endothelial Cells in Culture
Authors: Una S. Ryan, James W. Ryan
Journal: Environmental Health Perspectives (1980)

Direct studies of the function of a given cell type often require that the cell type be obtained in pure culture. A number of different specific metabolic activities have been attributed to pulmonary endothelial cells, yet with few exceptions the conclusions were based on indirect evidence. Thus, to improve our ability to examine directly for specific metabolic activities, we began a program to obtain pulmonary endothelial cells in culture. Two methods have been developed: (1) cells can be obtained from pulmonary artery and vein of large animals (cow, pig), and (2) cells can be obtained from the microvasculature of small animals (rat, guinea pig, and rabbit). The latter technique can also be used to obtain cells from a lobe of lung from large animals and may be adaptable for use with human tissue. In the first technique, pulmonary arteries, free of blood, are filled with collagenase (0.25%, 500 units) in Puck's saline for 25 min. The collagenase mixture containing cells is removed and centrifuged. The pellet is resuspended and seeded into culture flasks. In the second method, lungs are perfused (artery to vein) with Krebs-Henseleit solution until the effluent is blood-free. Collagenase (0.25%, 500 units) is introduced, and the lungs are then perfused in the opposite direction (vein to artery) until the flow stops spontaneously (ca. 15 min). The detached cells are collected and seeded as before. The endothelial cells attach as small clumps (10-50 cells). Those flasks which contain more than 95% endothelial cells (by phase microscopy) are retained for culture and the lines are purified usng differential adherence procedures.The cells grow as monolayers with a cobblestone appearance. They contain Weibel-Palade bodies. They possess converting enzyme activity and are reactive with antibodies to converting enzyme, Factor VIII and alpha 2-macroglobulin. The cells synthesize prostaglandins and related substances. In addition, they possess ADPase and synthesize angiotensin-converting enzyme.
Head and neck cancer. Oral cavity: primary lesion
Authors: P. Rubin
Journal: JAMA (1971)

A uniform classification of cancers is the optimum basis for selection of treatment, since it allows for comparison of end results. To this end, the Union Internationale Contre le Cancrum (International Union Against Cancer [UICC])<sup>1</sup>and the American Joint Committee on Cancer Staging and End Result Reporting<sup>2</sup>have agreed to use a tumor, lymph node, metastases (TNM) system to categorize the primary lesions and the extent of involvement; general rules for clinical staging have evolved. The essential points in assessing the primary tumor in the oral cavity are inspection and careful palpation; these general rules also apply to evaluation of the carevical nodes. All staging must be based on findings prior to definitive treatment; the staging cannot be changed later. The main reason cases are excluded from the staging should be recurrent or previously treated disease. Surgical and pathologic assessment are not mandatory; however, they are of value
The Automobile. A Practical Treatise on the Construction of Modern Motor Cars, Steam, Petrol, Electric and Petrol-Electric. Based on Lavergne's "L'Automobile sur Route."
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Heart: The Methods for Their Diagnosis, Prognosis and Treatment.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal