tbuckley/cabot-search huggingface dataset:
Landmark perspective: The atypical pneumonia syndrome
Authors: S. Levin
Journal: JAMA (1984)

The 1938 article by Dr H. A. Reimann, a Philadelphia physician from Jefferson Medical College,<sup>1</sup>published inThe Journal, became widely quoted and popularized the term<i>atypical pneumonia</i>. Dr Reimann described the presence of a pneumonia syndrome with findings quite different from the lobar consolidation of classic pneumococcal pneumonia and stressed a possible viral etiology. His cases varied from afebrile upper respiratory tract illness to a severe, prolonged pneumonia associated with encephalopathy. Headaches and symptoms of tracheobronchitis often preceded the signs of pneumonia. Retrospectively, one might question why this article had such a substantial effect in subsequent years. Neither the syndrome nor the name<i>atypical pneumonia</i>originated with Dr Reimann. There were many reports from Europe in the early 1920s of an unusual acute pneumonia syndrome of unknown cause. Similar syndromes had been described in army troops, school academies, and colleges in the United States between 1931 and 1936.
Implanted bipolar pacemakers. Analysis of function
Authors: N. Robinson
Journal: JAMA (1973)

One hundred five pacemakers with bipolar electrodes have been observed in a pacemaker clinic serving a rural population. Pacemaker stimulus wave-form analysis and electronic stimulus interval counting were employed. Also, in selected cases, radiographic analysis of battery depletion was performed. Results show that a 1% increase in pacemaker rate is an accurate predictor of impending failure in units that are designed to undergo a rate change with battery depletion, and that radiography is helpful in cases of doubt. Wave-form analysis was useful only when other factors were unequivocally abnormal because of difficulty in standardizing the test.
Correction: Haemolytic disease of the newborn due to antibodies other than rhesus anti-D
Journal: BMJ (1981)

CorrectionsHaemolytic disease of the newborn due to antibodies other than rhesus anti-DWe regret that an error appeared in the second paragraph of our leading article on "Haemolytic disease of the newborn due to antibodies other than rhesus anti-D" (22 August, p 514).Line 4 on page 515 should have read "of these, 70 (6 %,',) were due to anti-c.By 1974 prophylactic....
Discussion on Paper of Dr. Boyd-Snee.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE NEWEST PHRENOLOGY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Misplaced State
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HOSPITAL FOR SPEECH DISORDERS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Married.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Oncology
Journal: JAMA Oncology (2015)

JAMA Oncology is committed to publishing infl uential original research, opinions, and reviews that advance the science of oncology and improve the clinical care of patients with cancer.Mission Statement JAMA Oncology is the defi nitive journal for scientists, clinicians, and trainees in the fi eld of oncology worldwide.Our original, innovative, and timely scientifi c and educational content provides a deeper understanding of cancer pathogenesis and recent treatment advances for our readers.JAMA Oncology aims to eff ectively convey the fi ndings of important clinical research, major scientifi c breakthroughs, actionable discoveries, and state-of-the-art treatment pathways to the oncology community.Our goal is that successful communication of new knowledge will ultimately translate to clinical benefi t for people living with and surviving cancer.
Abstract 2901: Doppler Ultrasound Enhances the Thrombolytic Activity of Tissue-Plasminogen Activator-Loaded Echogenic Liposomes
Authors: Melanie Moody, Susan T Laing, Shaoling Huang, Hyunggun Kim, Beverly Smulevitz, Yuejiao Zou, David D McPherson, Melvin E Klegerman
Journal: Circulation (2007)

Background: Ultrasound has been shown to enhance thrombolysis when used in conjunction with a thrombolytic agent. We have loaded echogenic liposomes (ELIP) with tissue plasminogen activator (tPA) and shown that mechanical non-imaging 1 MHz ultrasound can enhance thrombolysis in an in vitro clot model. This study aimed to evaluate the efficacy of clinical Doppler ultrasound to enhance the thrombolytic effect of our tPA-ELIP. Materials and Methods: A standard reproducible whole blood porcine clot model was used. Clots were blotted dry, weighed, and placed in 10 ml fresh frozen porcine plasma. Clots were treated with tPA-ELIP with and without Doppler ultrasound (pulsed wave ultrasound, 6.6 MHz, 2 minute-treatment time). After 30 minutes, clots were similarly weighed. Data are reported as percent clot mass loss. Samples of the plasma were assayed for D-dimer levels. Results: Exposure of tPA-ELIP to clinical Doppler ultrasound enhanced thrombolysis (p=0.015 vs. tPA alone or Doppler ultrasound alone; Figure ). There was a trend towards higher D-dimer levels in the clots treated with tPA-ELIP + clinical Doppler ultrasound, corresponding to the higher percent clot mass loss seen in this treatment group. Conclusions: This study demonstrates the ability of clinical Doppler ultrasound to enhance the thrombolytic effect of our tPA-ELIP in an in vitro clot model. This demonstrates the potential to translate our novel thrombolytic technique of combining a thrombolytic-loaded contrast agent and ultrasound to patient care.
Surgeon volume vs hospital volume: which matters more?
Authors: Stephen F. Jencks, Paul W. Eggers
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Dr Detsky<sup>1</sup>provides a carefully designed analysis of how we might evaluate the cost-effectiveness of clinical trials in improving health. He argues, and Dr Fletcher<sup>2</sup>seems to concur, that the evidence of cost-effectiveness is so overwhelming that policymakers would provide more money for research if they understood the evidence. As Dr Fletcher points out, Dr Detsky substantially overstates the cost-effectiveness of trials because he does not include the cost of providing the tested treatment. A more serious problem, however, is that neither considers the extent to which the results of the trials actually change medical outcomes. The impact of a clinical trial on outcomes tends to be limited by at least five factors: (1) physicians remain unaware of the results, (2) not all physicians agree as to what the trial "really" proved or whether the results are generalizable, (3) many physicians believe that changes in
Cystic fibrosis in adults.
Journal: BMJ (1979)

Cystic fibrosis in adultsCystic fibrosis is the commonest semilethal genetic disorder in Caucasians.Its gene frequency is about 1:20 and it is transmitted as an autosomal recessive trait.Thus roughly one in every 2000 children is born with the disease, girls and boys in equal numbers.The disease is less common in blacks and mongoloid people.The biochemical sequence that leads to widespread dys-
Activity Testing of Alveolar Macrophages and Changes in Surfactant Phospholipids after Irradiation in Bronchoalveolar Lavage: Experimental and Clinical Data
Authors: F. Steinberg, B. Rehn, R. Kraus, K. Quabeck, J. Bruch, D. W. Beelen, U. W. Schaefer, C. Streffer
Journal: Environmental Health Perspectives (1992)

This study presents results of bronchoalveolar lavage (BAL) after irradiation to the lungs in mice as well as clinical data. The number of BAL cells, mainly macrophages, lymphocytes, and granulocytes, changed in a time-dependent manner. The phagocytic activity of the macrophages measured as the phagocytosis of microbeads and measured as the esterase activity also showed a strong time-dependent increase during the acute phase up to 21 days after irradiation. The contents of surfactant phospholipids (SF) and sphingomyelin (SPH; as a parameter for cell death) were quantified by HPLC. Both were significantly changed between day 2 and 21 after irradiation. Three BALs of a patient with idiopathic interstitial pneumonitis, who had received an allogenic bone marrow graft after total body irradiation with 10 Gy, showed similar effects in the cellular and surfactant parameters. These data indicate that there are positive interactions between the number of different BAL cells, macrophage activity, and SF and SPH content in the preclinical model of the mouse as well as in the clinical situation after lung irradiation.
Influence of Membrane Sodium Transport upon the Relation between Blood Lead and Blood Pressure in a General Male Population
Authors: Thierry Moreau, Patrick Hannaert, Genevieve Orssaud, Guy Huel, Ricardo P. Garay, Jean R. Claude, Bernard Juguet, Bernard Festy, Joseph Lellouch
Journal: Environmental Health Perspectives (1988)

Five red blood cell cation transport systems (RBCTS), together with blood lead level and blood pressure, were measured in 129 male adult subjects who were not occupationally exposed to lead or subsequent to a course of treatment for hypertension. Blood lead was positively related with systolic blood pressure, and to a lesser degree with diastolic blood pressure. Blood lead was found significantly negatively related to one of the RBCTS, Na+,K+ cotransport, and in addition, Na+,K+ cotransport appeared negatively related to blood pressure. Final results showed that blood lead no longer accounts for an increase in systolic blood pressure when Na+,K+ cotransport was taken into account; the same trend was observed with diastolic blood pressure. These findings suggest that a blood lead-related Na+,K+ cotransport impairment could explain the blood pressure increase observed to parallel the blood lead increase.
Interest of Eosinophil Count in Bacterial Infections to Predict Antimicrobial Therapy Efficacy—Reply
Authors: Audrey Stokes Kulaylat, Erica L. Buonomo, David B. Stewart
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
JAMA Surgery
Journal: JAMA Surgery (2019)

Effect of an Incentive Spirometer Patient Reminder 579What is the effect of a use-tracking incentive spirometer reminder on patient adherence and clinical outcomes after coronary artery bypass grafting surgery?In a randomized clinical trial of 160 patients, Eltorai and colleagues found that the patient reminder improved incentive spirometer use adherence and reduced atelectasis severity, early postoperative fevers, noninvasive positive pressure ventilation use, intensive care unit length of stay (by a day), and 6-month mortality rates.Invited Commentary 588 CME jamanetwork.com/learning Every Day Matters: Longer Duration of Prophylaxis and Harm 590In a large cohort study at a VA medical facility, Branch-Elliman and colleagues found that every extra day of antimicrobial prophylaxis increases postoperative adverse events but does not improve rates of surgical site infections.Findings support guideline recommendations that antimicrobial prophylaxis should not be continued after skin closure.Limiting antimicrobial exposure to intraoperative and preoperative doses only is a rare opportunity to simultaneously improve care and reduce medical costs.
Abstract 3037: Long-Term Positive Left Ventricular Remodeling After Correction of Severe Organic Mitral Regurgitation: A Pilot Cardiovascular Magnetic Resonance Study
Authors: Jessica A Haffajee, Thomas H Hauser, Ralph de la Torre, Warren J Manning, Eli V Gelfand
Journal: Circulation (2007)

Background : One of the goals of referring patients with chronic severe organic mitral regurgitation (MR) for corrective mitral valve surgery (MVR) is preservation of postoperative global left ventricular (LV) systolic function. Using cardiovascular magnetic resonance (CMR) methods, we have previously reported an intermediate decline in postoperative LV ejection fraction (LVEF). We hypothesized that years following successful surgical correction, there would be evidence of ongoing positive ventricular remodeling with improvement in systolic function and used quantitative CMR to prospectively test this hypothesis. Methods : Fourteen patients (50% female, 55 +/− 11.3 yrs) underwent elective MVR for severe organic MR. Quantitative CMR was performed preoperatively and at median times of 3 months and 27 months following MVR. Results : See Table . At 3 mo, postoperative LVEF declined by 27% (p&lt;0.001) but recovered to preoperative values at 27 mo (p=NS vs. pre, p&lt;0.001 vs. 3 mo). Twelve (86%) of 14 patients had normal LVEF 27 mo after MVR. LV end diastolic volume index (LVEDVI) declined by 32% at 3 mo (p&lt;0.001) and by an additional 9% at 27 mo (p&lt;0.001 vs. pre, p&lt;0.019 vs. 3mo), with 12 (86%) of 14 patients achieving normal volumes. LV mass index (LVMI) declined by 22% at 3 mo (p&lt;0.001) with a further decline of 17% at 27 mo (p&lt;0.001 vs. pre, p&lt;0.001 vs. 3 mo). All patients had normal LVMI at long-term follow-up. Conclusions : In this prospective pilot study, we demonstrate ongoing positive LV remodeling beyond the intermediate postoperative period. These changes likely reflect normalization of cardiac hemodynamics following correction of MR with decreases in ventricular volumes and mass as well as preservation of systolic function. Comparison of LV parameters preoperatively, at 3 mo, and at 27 mo following MVR
BRAIN FEVER
Authors: Louis Casamajor
Journal: JAMA (1952)

In the early years of the 19th century there began to appear in European medical journals—especially the French—descriptions of a disease variously known as brain fever, hydrocephalic fever, and, rarely, encephalitis.<sup>1</sup>At times the name of Pinel is attached to brain fever, and it may be that he originally described it. In any event he is credited with having differentiated it from meningitis. By the middle of the century no further medical articles appeared, although novelists continued to utilize the disease as dramatic incident until well along toward the end of the century. Early American textbooks of neurology contained no reference to the disease. This disease occurred apparently almost entirely in children. It is difficult to get a clear idea of the clinical picture, for more than one condition was included in this terminology. Some cases were fatal, and the necropsies usually showed meningitis, most likely tubercular. Some patients
Progressive multifocal leukoencephalopathy and cytarabine. Remission with treatment
Authors: W. R. Bauer
Journal: JAMA (1973)

A patient with previously diagnosed chronic lymphocytic leukemia developed progressive multifocal leukoencephalopathy (PML) and was treated with cytarabine, with a clinical remission. Histologic studies of a brain biopsy confirmed the diagnosis of PML. Viral and immunological studies suggest that the biopsy contained a papovavirus similar to an agent isolated from another patient with PML. Further controlled clinical trials with antiviral agents are indicated.
THE ORIGIN OF "VITAMIN A"
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal