tbuckley/cabot-search huggingface dataset:
Renal Disease and Metabolic Effects of Tetracycline
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
一项比较两种银屑病治疗方法的试验: Guselkumab 和富马酸酯
Journal: British Journal of Dermatology (2020)

这项来自德国的研究旨在将一种名为"guselkumab"的新药与一种在德国通常用于治疗银屑病的"富马酸酯 (FAE)"进行比较。 银屑病患者通过随机分配接受 guselkumab 或 FAE,并且在 24 周后,研究人员评估了药物的效果(疗效)和耐受性 (安全性)。 使用银屑病面积和严重程度指数 (PASI) 记录患者银屑病的发红程度、厚度和范围,并衡量疗效(PASI 分值降低, 即表示症状减轻)。例如,如果患者的 PASI 得分为 75 分,表示 PASI 分值比最初时下降了 75% 或以上。 在这项研究中,第 24 周时,有 82% 的 guselkumab 组患者和 14% 的 FAE 组患者相比基线 PASI 评分改善了至少 90%(PASI 90 缓解)。这意味着,与 FAE 组相比,guselkumab 组患者症状缓解更明显。 患者回答"皮肤病生活质量指数 (DLQI)"调查问卷,以衡量皮肤疾病对生活质量不同方面的影响,例如症状和感 觉、日常活动、休闲、人际关系和治疗的副作用。治疗 24 周后,与 FAE 组患者 (17%
HEMOSTASIS AND HEMORRHAGE IN LIVER DISEASE
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Endoscopic management of gastrointestinal motility disorders – part 1: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Authors: Bas L. A. M. Weusten, Maximilien Barret, Albert J. Bredenoord, Pietro Familiari, Jan-Michel Gonzalez, Jeanin E. van Hooft, Sauid Ishaq, Vicente Lorenzo-Zúñiga, Hubert Louis, Suzanne van Meer, Helmut Neumann, Daniel Pohl, Frederic Prat, Daniel von Renteln, Edoardo Savarino, Rami Sweis, Jan Tack, Radu Tutuian, Jan Martinek
Journal: Endoscopy (2020)

Correction to:Endoscopic management of gastrointestinal motility disorders – part 1: European Society of Gastrointestinal Endoscopy (ESGE) GuidelineEndoscopy 2020; 52(06): 498-515DOI: 10.1055/a-1160-5549
Abstract 4963: A novel intestinal microbiome-derived peptide modulates immune cell activity and the tumor microenvironment
Authors: Helena Kiefel, Dhwani Haria, Yuliya Katlinskaya, Divya Ravichandar, Lily McLaughlin, Sunit Jain, Thomas Weinmaier, Shoko Iwai, Todd DeSantis, Toshi Takeuchi, Karim Dabbagh, Kareem Graham
Journal: Cancer Research (2019)

Abstract The composition of the gut microbiota affects cancer development, progression, and response to therapy. A number of commensal bacteria, including Bifidobacterium, have been associated with increased response to immune checkpoint inhibitors in mouse tumor models and in cancer patients. We hypothesized that secreted peptides or proteins are driving the Bifidobacterium-mediated effects. Using our unique bioinformatic-driven discovery platform we nominated putatively secreted Bifidobacterium-derived peptides for evaluation in immune cell effector assays. We demonstrate that several of the peptides induce secretion of pro-inflammatory cytokines (e.g., IL-6, TNF) by in vitro-generated mouse and human dendritic cells, as well as effector cytokine secretion (e.g., IFNγ, IL-2) by mouse splenic T lymphocytes in vitro. To investigate the function of Bifidobacterium-derived peptides in the context of the tumor microenvironment we injected the candidate peptide SG-A directly into the tumor of CT26 tumor-bearing mice and analyzed the immune phenotype using the Nanostring PanCancer Immune Profiling panel and flow cytometry. Both Nanostring as well as flow cytometry analysis showed an increase in CD45+ tumor-infiltrating lymphocytes in SG-A treated tumors. SG-A peptide also induced the upregulation of dendritic cell function genes (CD40, CD83, and CD86) and multiple effector cytokines and chemokines. Re-stimulation of tumor-draining lymph node cells with AH1 peptide (a CT26 tumor-derived antigen) also increased induction of IFNγ in SG-A treated animals (vs. vehicle-treated controls). Collectively, our results demonstrate the utility of the Second Genome discovery platform for leveraging microbiome science to identify novel immunoregulatory factors. This platform offers a promising approach to identify agents with potential for use as therapeutics in cancer immunotherapy. Citation Format: Helena Kiefel, Dhwani Haria, Yuliya Katlinskaya, Divya Ravichandar, Lily McLaughlin, Sunit Jain, Thomas Weinmaier, Shoko Iwai, Todd DeSantis, Toshi Takeuchi, Karim Dabbagh, Kareem Graham. A novel intestinal microbiome-derived peptide modulates immune cell activity and the tumor microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4963.
General Medicine.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians' antinuclear war group expanding to include child health
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive value of sputum cytology
Journal: Thorax (1987)

Predictive value of sputum cytologyThe paper by Dr J Benbassat and others (March 1987;42:165-72) contained miscalculations in two areas.The first relates to the calculated age and sex specific annual incidence rates (per 100 000 population) ofcancer of the lung and bronchi by smoking habit in table 3.This should read as in the table below.
Transactions of the Medical Association of Georgia, Fifty-second Annual Session.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Distribution of pyruvate dehydrogenase dihydrolipoamide acetyltransferase (PDC-E2) and another mitochondrial marker in salivary gland and biliary epithelium from patients with primary biliary cirrhosis
Authors: R Joplin
Journal: Hepatology (1994)

Previous studies in which quantitative immunofluorescence was used have shown that certain biliary epithelial cells in liver with primary biliary cirrhosis show increased levels of pyruvate dehydrogenase dihydrolipoamide acetyltransferase compared with controls. This study was designed to determine whether the increase in intensity of pyruvate dehydrogenase dihydrolipoamide acetyltransferase in biliary epithelial cells is accounted for by an increase in the number of mitochondria in the same cells. A double-antibody staining technique was used with antibodies specific for pyruvate dehydrogenase dihydrolipoamide acetyltransferase and another mitochondrial inner membrane marker, recognized by the mouse monoclonal antibody MCA151A. Distribution of the antigens was studied in sections of liver and salivary gland, an additional site that is frequently involved in primary biliary cirrhosis. Confocal microscopy was used to quantify the intensity of fluorescence resulting from binding of fluorochrome-labeled antibody. In both liver and salivary glands MCA151A binding was similar in normal and sections with primary biliary cirrhosis and corresponded to the predicted distribution of mitochondria in these tissues. In the liver staining was less intense in biliary epithelial cells than in hepatocytes. In salivary gland binding of both antibodies was predominantly localized to duct cells, with those forming striated ducts, known to be rich in mitochondria, being most intensely stained. There was high coincidence of the two antigens in salivary glands (p<0.01) and in biliary epithelial cells from normal liver (p=0.01). However, in liver with primary biliary cirrhosis, despite high coincidence between the antigens on hepatocytes, biliary epithelial cells showed high intensity of pyruvate dehydrogenase dihydrolipoamide acetyltransferase but not MCA151A. The results indicate that an increase in mitochondria does not account for high intensity of pyruvate dehydrogenase dihydrolipoamide acetyltransferase in biliary epithelial cells in liver with primary biliary cirrhosis. (HEPATOLOGY 1994;19:1375–1380).
Louis Marshall
Authors: William R. Laird
Journal: New England Journal of Medicine (1954)

A LITTLE publicized but significant figure in the early history of the United States is Louis Marshall, the brother of John Marshall, United States Chief Justice. His contribution to education has been largely forgotten. He was, however, a pioneer in bringing into education the spirit of experiment, adventure and the belief that the educative process should promote growth by developing natural instincts rather than suppressing them. It was not until 1900 that this idea, long prevalent in elementary education, began to spread among the colleges.The programs of the University of Chicago, St. John's College, Rollins College, the University of . . .
Correction
Authors: Antonio Martinez-Hernandez, Jacquelyn Maher, Nancy Bucher, Randy Jirtle, George Michalopoulos, Nelson Fausto, Donald Miller, Katherine Ponder, Raymond Dubois, M Flye, Douglas Labrecque, Snorri Thorgeirsson, Anna Diehl, Rebecca Taub, George Wu, Mark Czaja, Hyam Leffert, Katherine Koch, Lola Reid, Alastair Strain, Eric Sandsen, Thomas Starzl, Antonio Francavilla, David Brenner, James Darnell, Betsy Kren, Dominique Morello, Wallace Mckeehan, Clifford Steer, Pamela Ballinger
Journal: Hepatology (1993)
Blood Type, Blood Clot, and the Pill
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Propranolol therapy in patients with cardiac disease
Authors: S. Wessler
Journal: JAMA (1968)

Dr. Sidney Jick, Associate Attending Physician, the Jewish Hospital of St. Louis, and Clinical Instructor in Medicine, Washington University School of Medicine: A 67-year-old business executive with a 20-year history of chronic atrial fibrillation was hospitalized in February 1967 because of recurrent palpitation during slight exertion. During the past 20 years, despite large doses of digitalis and other drugs including quinidine sulfate, the patient often experienced episodes of rapid heart action, particularly on very modest effort. In 1965, cardioversion was successfully performed with 400 watt-seconds, but normal sinus rhythm was maintained for only two days. Physical examination revealed an elderly white man in no distress. Pulse rate was 78 beats per minute and irregular; blood pressure was 130/95 mm Hg and respiration rate was 16 per minute. Findings from examination of the head, ears, eyes, nose, throat, abdomen, and extremities were unremarkable. The chest was clear to percussion and auscultation.
Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors
Authors: W. F. Stewart
Journal: JAMA (1992)

<h3>Objective.</h3> —To describe the magnitude and distribution of the public health problem posed by migraine in the United States by examining migraine prevalence, attack frequency, and attack-related disability by gender, age, race, household income, geographic region, and urban vs rural residence. <h3>Design.</h3> —In 1989, a self-administered questionnaire was sent to a sample of 15000 households. A designated member of each household initially responded to the questionnaire. Each household member with severe headache was asked to respond to detailed questions about symptoms, frequency, and severity of headaches. <h3>Setting.</h3> —A sample of households selected from a panel to be representative of the US population in terms of age, gender, household size, and geographic area. <h3>Participants.</h3> —After a single mailing, 20468 subjects (63.4% response rate) between 12 and 80 years of age responded to the survey. Respondents and non-respondents did not differ by gender, household income, region of the country, or urban vs rural status. Whites and the elderly were more likely to respond. Migraine headache cases were identified on the basis of reported symptoms using established diagnostic criteria. <h3>Results.</h3> —17.6% of females and 5.7% of males were found to have one or more migraine headaches per year. The prevalence of migraine varied considerably by age and was highest in both men and women between the ages of 35 to 45 years. Migraine prevalence was strongly associated with household income; prevalence in the lowest income group (&lt;$10 000) was more than 60% higher than in the two highest income groups (≥$30 000). The proportion of migraine sufferers who experienced moderate to severe disability was not related to gender, age, income, urban vs rural residence, or region of the country. In contrast, the frequency of headaches was lower in higher-income groups. Attack frequency was inversely related to disability. <h3>Conclusions.</h3> —A projection to the US population suggests that 8.7 million females and 2.6 million males suffer from migraine headache with moderate to severe disability. Of these, 3.4 million females and 1.1 million males experience one or more attacks per month. Females between ages 30 to 49 years from lower-income households are at especially high risk of having migraines and are more likely than other groups to use emergency care services for their acute condition. (<i>JAMA</i>. 1992;267:64-69)
Relief of terminal pain
Journal: BMJ (1975)

Sterilisation of childrenThe Department of Health has issued a discussion paper (HSI/MED D1) on the sterilisation of children under 16 years of age.Comment on the paper is being sought from area health authorities, community health councils, women's and children's organisations, and professional bodies.Suggestions made in the paper include the introduction of a statutory requirement that sterilisation should be approved by an in- dependent local ethical committee; giving the Secretary of State power to appoint a committee for the same purpose; and pro- posals for a notification procedure, which might be simply administrative or a means of ensuring that any permissions thought neces- sary had in fact been obtained. Childhood tuberculosisThe Medical Research Council's National Tuberculin Survey has shown that the num- bers of schoolchildren infected with tuber-
Inhibition of Demand Pacemakers by Skeletal Muscle Potentials
Authors: David Mymin
Journal: JAMA (1973)

Inhibition of demand pacemakers by interference arising from myopotentials has not received due recognition as a significant clinical problem. We have encountered four cases in which cerebral ischemic episodes resulted from pacemaker inhibition associated with isometric contraction of the subadjacent pectoralis major. It can be shown that even myoelectric signals detected on the skin surface are capable of inhibiting implantable ventricular-inhibited units. In a sample of our patients, 24% were shown to be vulnerable to pectoral muscle contraction by routine electrocardiographic testing. The problem may be very difficult to eliminate since significant and even maximal myoelectric energy levels may occur at frequencies within the QRS spectrum.
Percutaneous needle biopsy of the lung in evaluation of pulmonary disorders
Authors: F. Manfredi
Journal: JAMA (1966)

Percutaneous needle biopsy of the lung has been shown to be of value in the diagnosis of both diffuse and localized diseases which involve the lung.<sup>1-10</sup>The use of this procedure, in which a cutting-type needle (eg, Vim-Silverman, Franklin-Silverman, Jack) is used, has now been reported in approximately 400 cases. The results have been striking. The complications in most instances have been minimal, and no deaths from the procedure have been recorded. Histologically interpretable lung tissue has been returned in approximately 90% of the biopsy attempts (Table). The percentage return of tissue has been found to be higher in solid localized peripheral lesions than those demonstrating diffuse pulmonary parenchymal involvement, but the difference has been small. Tissue which has proved to be diagnostically useful, either primarily or in a supporting manner, has been returned in 77% of biopsies (Table). These figures are similar and comparable to those published for
Hospitalizations Among the Elderly
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal