tbuckley/cabot-search huggingface dataset:
Abstract B35: The strength of drug selection determines the maximum fitness cost of resistance mutations in culture and xenografts
Authors: Lee A. Albacker, Rainer Kohler, Ralph Weissleder, Peter K. Sorger
Journal: Clinical Cancer Research (2015)

Abstract This abstract is being presented as a short talk. A full abstract is printed in the Proffered Abstracts section (PR07) of the Conference Proceedings. Citation Format: Lee A. Albacker, Rainer Kohler, Ralph Weissleder, Peter K. Sorger. The strength of drug selection determines the maximum fitness cost of resistance mutations in culture and xenografts. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; Jun 18-21, 2014; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(4 Suppl): Abstract nr B35.
Trauma, Violence, Abuse
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studying reproductive risks, smoking
Authors: H. Cole
Journal: JAMA (1986)

No longer can those persons who smoke cigarettes naively assume that their habit harms only themselves, and women and their unborn infants are at special risk. New warnings from the surgeon general of the Public Health Service, displayed on cigarette packages and in advertisements, attest that in addition to causing lung cancer, heart disease, and emphysema, smoking can complicate pregnancy, resulting in premature birth, low birth weight, and fetal injury. These risks and others, including a greater risk of infertility, spontaneous abortion, ectopic pregnancy, and earlier menopause, were recently highlighted at the first International Conference on Smoking and Reproductive Health. The conference, sponsored by Family Health International, Research Triangle Park, NC; the Centers for Disease Control, Atlanta; Office on Smoking and Health, Agency for International Development, and Health Resources and Services Administration, Washington, DC; National Institute of Child Health and Human Development, Bethesda, Md; University of California, San Francisco; and
Association of volume with outcome of coronary artery bypass graft surgery. Scheduled vs nonscheduled operations
Authors: J. A. Showstack
Journal: JAMA (1987)

Empirical evidence suggests that mortality rates for coronary artery bypass graft (CABG) surgery are lower in hospitals that perform a higher volume of the procedure. In recent years, the criteria for CABG surgery have been expanded to include patients with a wide variety of co-morbidities. To address the question of whether the volume-outcome relationship continues to exist for this new group of patients, discharge abstracts for 18986 CABG operations at 77 hospitals in California in 1983 were analyzed using multiple-regression techniques. Higher-volume hospitals had lower in-hospital mortality (adjusted for case mix); this effect was greatest in patients who might be characterized as having "non-scheduled" CABG surgery. Higher-volume hospitals also had shorter average postoperative lengths of stay and fewer patients with extremely long stays. The results of this study suggest that the greatest improvement in average outcomes for CABG surgery would result from the closure of low-volume surgery units. (<i>JAMA</i>1987;257:785-789)
Infection Emergent
Authors: Joshua Lederberg
Journal: JAMA (1996)

The depredations of the global HIV pandemic have been a humbling experience for the scientific infectious disease community and the public health authorities. This can hardly be compared with the human suffering induced by this alien surprise, and what may still lie ahead. However, it may yet have some salutary effect if it alerts us to still further hazards that we face as a species in our competition with microbial competitors, who crowd us at the summit of the terrestrial food chain. This month,<i>JAMA</i>and 35 other journals worldwide will document the occurrence, causes, and consequences of emerging and reemerging infections. This resurgence of scientific interest has been matched in popular media, in the pages of newsmagazines, newspaper headlines, best-selling books, TV shows, and movies like<i>Outbreak</i>. Tangible responses by governments in the form of budgetary or staffing commitments remain negligible, and political debates about health have focused on
THE PUBLIC SERVICE.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aseptic Midwifery: A Correction
Authors: A Anderson, Basing- Toke Andrews, Mr Agar, J Atkinson, Hong Kong, Long Bloomer, Berlin Baglnsky, M Burns, Messrs Burroughs, Co Blair, ; Mr, B Beheim-Schwanbaeh, J Bays, London Browne, A Barrs, Messrs Blandy, Mr Bale, London Bid- Well, J Blake, St Batterham, G Crowe, ; Cox, Mr Carmichael, Brighton Collingwood, W Calvert, E Du, Cargona Company, W Drummond, A Davies, W Mca, Mr Ellis, ; Elberfeld, Farben Fabriken, F Mr, Johnson Fassett, T Fentem, Mr Gaskell, D Mcj, Butherglen Glen, H Gordon, J Gornall, J Gairdner, Mr Gay, Sunbury-On-Thames Haslett, Mr Horder, Birmingham Haslam, London Son, M Hepburn, J Hare, T Rime, R Jardine, Mr Jones, ' Johnston, Bolton Jenner, R Kirk, L Knuthsen, C Lamplough, G Lang, ; Leask, T Lyon, Mr Lee, J Page, Man- Chester Mr, ; Matthews, London Mertens, J Mcnamara, Brotton Mogachen, T Myles, H Mao- Evoy, W Milligan, London Napier-Jones, W Neale, Greenock Niven, J Naumann, Mr Pirkis, J Polan, W Parker, Mr Pink, Mr Palmer, Gamlingay Mr, Broadstairs Raven, L Roberts, J Riddell, J Rigby, E Reynolds, J Ridge
Journal: BMJ (1898)

should take plenty.The body needs more food to sustain it in an extremely cold climate than in the lower latitudes especially when con- tinually employed in arduous outdoor work.3to withstand the col-d one needs a large amount of such food as beans rice, meal and flour, and of fatty meats.The outfit should also inciude a,box of candles, two dozen bars of soap, mustard, Jamaica ginger, and a half tin of matches.A small medicine case well stocked with standard preparations is necessary, and quinine and calomel should always form a part.Also acetic acid, one teaspoonful diluted in water, will make a glassful of ordinary vinegar, and citric acid will make lemonade and also prevent scurvy." In the way of groceries we suggest the following for one man for a year: 350 lbs. of flour, .15olbs. of bacon, Ioo lbs. of beans, I5 lbs. of tea, 25 lbs. of rice, 50 lbs. of dry salt pork, 0oo lbs. of dried fruits, so lbs. of salt (for canning and cooking), 2 lbs. of evaporated vinegar, 20 lbs. of
PDTM-01. PEDIATRIC RADIATION-INDUCED GLIOBLASTOMA: TRANSCRIPTOMIC AND DRUG SCREENING ANALYSIS OF PRIMARY PATIENT SAMPLES
Authors: John DeSisto, Andrew Donson, Patrick Flannery, Rakeb Lemma, Bridget Sanford, Nicholas Foreman, Rajeev Vibhakar, Kenneth Jones, Adam Green
Journal: Neuro-Oncology (2017)
Transactions of the American Surgical Association. Volume XIII.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An era of stress for health institutions. The 1980s
Authors: R. J. Blendon
Journal: JAMA (1981)

The United States enters the 1980s beset with serious economic problems. The picture currently projected from long-term economic forecasts supplemented by national opinion polls for the early to mid-1980s suggests a downturn in our nation's economy and a sharp decrease in monies available for further growth or improvements in America's medical care system. These prospects have serious implications for many of America's most important health care institutions, their health professionals, and how they plan for the future. (<i>JAMA</i>1981;245:1843-1845)
Clinical applications of His' bundle electrocardiography
Authors: H. L. Greene
Journal: JAMA (1978)

Intracardiac ECG recording and stimulation are useful to evaluate conduction block, bradyarrhythmias, and tachyarrhythmias whose importance or mechanisms are uncertain from a surface ECG in the symptomatic patient. The technique is safe, with only rare complications. The response to medication can be tested during the procedure, helping to maximize the response to medical therapy. (<i>JAMA</i>240:258-260, 1978)
Survival Data for Patients Undergoing Chronic Intermittent Hemodialysis.
Authors: Edmund J. Lewis
Journal: Annals of Internal Medicine (1968)

s1 May 1968Survival Data for Patients Undergoing Chronic Intermittent Hemodialysis.Edmund J. Lewis, M.D., D. Marie Foster, A.B., J. de la Puente, M.P.H., Cathlene ScurlockEdmund J. Lewis, M.D.Search for more papers by this author, D. Marie Foster, A.B.Search for more papers by this author, J. de la Puente, M.P.H.Search for more papers by this author, Cathlene ScurlockSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1182_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSurvival data have been compiled on patients undergoing chronic intermittent hemodialysis, based on the experience of 14 dialysis centers in the United States. Cumulative survival rates were calculated using the life table method. A group of 302 patients, representing approximately one third of the total dialysis population in the United States, was observed over a period of up to 7 years; 53 patients have been observed for 2 or more years. Of the original 302 patients, 48 are dead. Four of these deaths were directly attributable to human or mechanical error during the dialysis procedure. Eighty-seven percent of the patients... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Arlington, Virginia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1182-1182KeywordsMedical dialysis Issue Published: 1 May 1968 PDF DownloadLoading ...
PLoS Medicine Issue Image | Vol. 7(6) June 2010
Journal: PLoS Medicine (2010)

A shocking and intolerable number of women die or are disabled each year trying to give birth- more than 10 million women according to the WHO, 99% of whom are in developing countries. In an Editorial linked to a new series on maternal, neonatal, and child health in Africa, the PLoS Medicine editors argue that maternal health policies must recognize the full spectrum of women's sexual and reproductive health for improvements in maternal health to be realized. The goal of the series is to identify scientific interventions and accelerate actions that are tailored and specific to sub-Saharan Africa. Based on consultations with 60 scientists and policy makers from nine countries and using local and national data, the series updates the current status of maternal and child health in the region, reviews evidence based solutions, and identifies high-impact opportunities for reducing maternal and child mortality. Image Credit: Pierre Holtz for UNICEF (hdptcar.net)
DNR in the OR
Authors: R. D. Truog
Journal: JAMA (1992)

<h3>To the Editor.</h3> —As anesthesiologists, we are largely in agreement with the thoughtful analysis by Walker<sup>1</sup>of DNR orders in the OR.<sup>2</sup>Hospital policy should be flexible concerning the suspension of DNR orders in the perioperative period. We disagree, however, with the presumption that flexibility on this issue implies neutrality. Just as otherwise healthy and competent patients have the right to refuse life-saving surgery, so do patients with DNR orders have the right to refuse resuscitation in the OR. But just as the former patients will almost always find it in their best interest to undergo life-saving surgery, so will most patients with DNR orders, when properly informed, regard it in their best interest to have these orders suspended during the perioperative period. One of the most important reasons for a seriously ill patient to choose DNR status is that cardiopulmonary resuscitation outside of the OR often
Pharmacoepidemiology
Authors: Louis Lasagna
Journal: JAMA (1995)

Five years have elapsed since the first edition of this book, and a lot has happened to pharmacoepidemiology in that time. (The reprinted preface to the first edition is mysteriously dated three years too early.) There are now a large International Society of Pharmacoepidemiology and a spate of journals devoted to the art and science of the field. Pharmacoepidemiologic data, coupled with pharmacoeconomic data and quality-of-life studies, play an increasingly important role in drug approval, drug withdrawal, and decisions about drug pricing and reimbursement. To take account of these and other changes, editor Brian Strom has added 17 new chapters and dropped two old ones. The result is a more complete and more useful book than its predecessor, which was already a significant contribution to the education of members of many disciplines and professions. As before, there is considerable attention given to various databases, and their strengths and weaknesses are
TOC 6th page
Authors: Zhikang Peng, Andrew Beckett, Renata Engler, Donald Hoffman, Nancy Ott, F Estelle, R Simons, David Fleischer, Mary Kay Conover-Walker, Lynn Christie, A Burks, Robert Wood, John Upham, Patrick Holt, Angie Taylor, Catherine Thornton, Susan Prescott, Swansea Australia, Amal Nassif, Armand Bensussan, Laurence Boumsell, Aurelien Deniaud, Homayoun Moslehi, Pierre Wolkenstein, Martine Bagot, Jean-Claude Roujeau, Elisabetta Pace, Rosalia Gagliardo, Mario Melis, Stefania Grutta, Maria Ferraro, Liboria Siena, Giovanni Bonsignore, Mark Gjomarkaj, Jean Bousquet, Antonio Vignola, Frank Siebenhaar, Petra Staubach, Martin Metz, Markus Magerl, Ju ¨rgen Jung, Marcus Maurer, Hyoung Doo Shin, Kyong Park, Choon-Sik Park, Sara San-Juan, Maria Caballero, Susana Monzo ´n, Ignacio Moneo, Oren Durham, Gregg Mitman
Journal: Journal of Allergy and Clinical Immunology (2004)
Refrigeration Anaesthesia
Authors: E. S. R. Hughes
Journal: BMJ (1947)

first by Lister, who describes mixing blood and carbolic acid into a paste and using it to fill wounds.Results.-When the dressing was removed healing in all cases was either complete or sufficiently advanced to shield the deeper parts of the wound from infection.All wounds were dry in three weeks from operation, and have remained so since for periods varying from nine months to two and a half years.It may be noted that no particular benefit has been observed to follow the local or general use of penicillin in cases in which all the infected bony and soft tissue could not be removed.Such sites of infection as the upper end of the femur or the vertebrae still remain most intractable once a communication, temporary or permanent, has been formed with the outer surface of the body. Summary and ConclusionsThree series of cases are reported: 31 of acute osteomyelitis; 4 of acute suppurative arthritis; 5 of chronic osteomyelitis.Of the acute cases 50% were in infants under 1 year old.Dosages of penicillin were relatively small-1,000 units per lb.(454 g.) body weight per twenty-four hours for three weeks.In acute osteomyelitis and arthritis, surgery was confined to aspiration of pus.Immobilization was partial and for short periods.Radiological changes observed were far less serious clinically than might have been expected from their marked character.In suitable cases of chronic osteomyelitis excision of infected tissue and primary suture is advised.Mortality was nil.Complete restoration of function occurred in all but one of the acute cases.There was apparent complete healing in all the chronic cases.We wish to acknowledge the kindness of physicians and surgeons at the Hospital for Sick Children, Great Ormond Street, who have permitted us to include some of their cases in this paper.We are also much indebted to Miss Eileen Rawlings for her tireless clerical assistance.
Association of blood pressure and polychlorinated biphenyl levels
Authors: K. Kreiss
Journal: JAMA (1981)

The geometric mean serum level of polychlorinated biphenyls (PCBs) of 458 persons in a communitywide study was 17.2 μg/L, with 80% to 90% having levels within the range found in other community groups. As a dependent variable, PCB levels were found to be positively related to age, even when controlled for all other variables associated with PCB level: sex, local fish consumption, obesity, serum cholesterol level, and alcohol consumption. No major point source of PCB contamination was found, and fish taken in the drainage of a major population center had mean PCB levels below the current enforceable Food and Drug Administration tolerance of 5 mg/kg. As an independent variable, serum PCB levels were positively associated with γ-glutamyl transpeptidase level, serum cholesterol level, and measured blood pressure. The PCB-blood pressure association, which was independent of age, sex, body mass index, and social class, must be confirmed in other exposed populations. (<i>JAMA</i>1981;245:2505-2509)
Journal summary
Journal: Annals of the Rheumatic Diseases (1989)

LeaderPregnancy and phospholipid antibodies p 795 This issue of the Annals looks particularly at many items of interest in systemic lupus erythematosus (SLE).The association between abortion and the presence of phospholipid antibodies is now well re- cognised.Coagulation abnormalities in vivo are well described with them, and perhaps the high risk of abortion when these antibodies are present is due to placental infarction.This appears to be a particular problem in SLE, and the leader examines this at length.There is still controversy about the best way to treat affected women and the author very sensibly calls for a properly controlled prospective trial to throw light on the matter.
REJUVENATION BY TESTICULAR TRANSPLANTATION AND OCCLUSION OF THE SEMINAL DUCTS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal