tbuckley/cabot-search huggingface dataset:
Caudal Analgesia in First-Stage Labor: Effect on Uterine Activity and Cardiovascular System
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P035: Association Between Caregiver and Child Metabolic Risk Factors: Hispanic Community Health Study/Study of Latino (SOL) Youth
Authors: Mercedes R Carnethon, Srikant I Bangdiwala, A. Talavera, Krista Perreira, Samantha Reina, Marha L Daviglus, Guadalupe X Ayala, Alan M Delamater, Elizabeth R Pulgaron, Carmen R Isasi
Journal: Circulation (2016)

Background: There is limited prior research on the association of metabolic risk factors between youth and their caregivers within Latino families despite the high burden of obesity and the young age of onset of metabolic disorders. Hypothesis: Obesity and metabolic risk factors are correlated between youth and their caregivers. Methods: SOL Youth is a cross-sectional ancillary study of boys and girls ages 8 to 16 years old whose parents/caregivers participated in the HCHS/SOL. We studied 728 boys, 738 girls and 1,020 caregivers (86% women) who completed a clinical examination. Body mass index (BMI), waist circumference, systolic and diastolic blood pressure, fasting glucose, hemoglobin A1c (HbA1c) and lipids (total-, HDL-, and LDL- cholesterol and triglycerides) were measured. Obesity was determined as &gt; 95 th age- and gender- specific percentile of BMI in youth and BMI &gt; 30 kg/m 2 in adults. We used weighted logistic regression to determine the odds of obesity in youth when caregivers were obese and we tested the association of each individual risk factor in caregivers with the same risk factor among youth using weighted linear regression. All models were adjusted for field center, youth age and ancestry and adult age, gender and education levels. Results: On average, boys and girls were 12 years old and caregivers were 41 years old. When caregivers were obese (vs. normal weight), girls and boys were 1.5 (95% CI: 0.92, 2.43) and 3.9 (95% CI: 2.44, 6.29) times more likely to be obese, respectively. Among girls, measures of adiposity, HbA1c, SBP and lipids (except triglycerides) were each positively associated with those same measures among caregivers (Table). Among boys, all measures except glucose and HbA1c were positively associated with caregiver measures. Conclusions: There were notable differences by gender in the odds of obesity among youth when a caregiver was also obese. Strong correlations between caregiver and youth metabolic risk factors underscore the need for family based interventions.
Phase II trial of Gliadel plus O<sup>6</sup>-benzylguanic (O<sup>6</sup>-BG) for patients with recurrent glioblastoma multiforme
Authors: J. A. Quinn, J. J. Vredenburgh, J. N. Rich, D. A. Reardon, A. Desjardins, S. Gururangan, A. H. Friedman, J. H. Carter, S. Threatt, H. S. Friedman
Journal: Journal of Clinical Oncology (2007)

2036 Background: The major mechanism of resistance to alkylnitrosourea therapy involves the DNA repair protein O 6 -alkylguanine-DNA alkyltransferase (AGT) which removes chloroethylation or methylation damage from the O 6 - position of guanine. O 6 -BG is an AGT substrate that inhibits AGT by suicide inactivation. A previous phase III randomized, placebo- controlled trial has shown that Gliadel wafer (G) significantly prolongs 6-month survival (55.5% for G vs. 35.6% for placebo) and median survival (28 weeks for G vs. 20 weeks for placebo) in patients with recurrent glioblastoma multiforme (GBM) (Brem et al 1995). Despite the success of G in prolonging survival we may be able to improve on this success by depleting AGT. Methods: Thus, we have designed a phase 2 trial where we define the activity and the toxicity of G in combination with a 5-day infusion of O 6 -BG in patients with recurrent GBM. In a prior study the O 6 -BG dose found to be effective in depleting tumor AGT activity at 48 hours was an IV bolus of 120 mg/m 2 over 1 hour followed by a continuous infusion of 30 mg/m 2 /d for 48 hours. In order to guarantee depletion of tumor AGT activity for at least 5 days after G placement, this O 6 -BG bolus was repeated on days 3 and 5 while continuing the infusion. Results: To date, 47 patients have been enrolled out of a planned accrual of 50 patients. The 6-month survival is 80% and the median survival is 47 weeks. The adverse events include the following: 3 episodes of grade 3 CSF leak (6%), 7 episodes of grade 3 wound infection at craniotomy site (15%), 6 episodes of hyponatremia (13%), 3 episodes of hydrocephalus (6%), 1 episode of hygroma (2%), 1 episode of infectious meningitis (2%), 1 episode of arachnoiditis (2%), 1 episode of grade 3 fever (2%). Conclusions: Thus far, this data demonstrates an increase in the efficacy of G when combined with O 6 -BG. Three additional patients will be enrolled for a total accrual of 50 patients. [Table: see text]
FIBROID TUMORS OF THE UTERUS.Address of the President, read before the Mississippi Valley Medical Society, Oct. 4-6, 1893.
Authors: R. STANSBURY SUTTON
Journal: JAMA (1894)

(Continued from page 10). <i>Prognosis</i>.—These tumors frequently cause death. Relatively, they are innoxious in the following order: subperitoneal, interstitial, cervical, and submucous. The last is especially dangerous, for it is almost always accompanied with great loss of blood; a very small tumor may cause fatal bleeding. Yet, although many of these tumors are not dangerous to life, they are liable at any time to cystic degeneration and to set up a train of evils demanding an entirely different consideration. These tumors occasionally disappear, as already stated, after the menopause or pregnancy. When submucous they are frequently expelled through the vagina as polypi. When the capsule ruptures under expulsive effort, they escape in mass or break down and are expelled piecemeal; ulceration of the capsule from any cause favors such a result. Nevertheless, these tumors occasionally destroy the patient through the advent of suppuration or necrosis of the tumor, producing septic
BOOK REVIEW
Authors: M. M. OKEN
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article BOOK REVIEW Get access Myeloma: Biology and Management , James S. Malpas , Daniel E. Bergsagel , Robert A. Kyle , eds . New York : Oxford University Press , 1995 . 581 pp., illus. $98.00. ISBN 0-19-262480-6 MARTIN M. OKEN, M.D. MARTIN M. OKEN, M.D. Director Virginia Piper Cancer Institute Abbott Northwestern Hospital and Clinical Professor of Medicine University of Minnesota800 E. 28th St. Minneapolis, MN 55407-3799 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 21, 1 November 1995, Pages 1636–1637, https://doi.org/10.1093/jnci/87.21.1636 Published: 01 November 1995
JAMA Psychiatry
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Miriam Cintron, Paul Ruich, Suzanne Walker, Diane Cannon, Connie Manno, Fred Marshall, Catherine Copyreaders, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Laura Glitman, Kenneth King, Donna Lane, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Kathryn Brokke, Fanny Brown, Paul Frank, Lenette Gardner-Gullens, Peter Kim, Rachell Lozano, Michaela Mark, Elizabeth Scientifi, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Will English, Mustafa Ishaq, Daniel Morrow, Reuben Rios, Ronna Henry, Joshua Bird, Karen Bucher, Samantha Welker, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Monica Smith, Jeff Ery, J Bonistalli, Kathy Russell, Mirna Monal, Stacey Mchugh, Marketing Thornbury, Tricia Classifi, Thalia Moss, Mike Harvey, Susan Henning, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Natasha Nekola, Ron Marketing, Paul Gee, Matt Herron, Elizabeth Solaro, Geoff Rey, Rick Bell, Lindsay Dawson, Craig Mccaff Rey, Michael Mcgraw, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Denise Steinhauser, Joe Advertising, Production Services, Kim Boler, Rhonda Brown, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Bernard Hengesbaugh, Dan Blazer, North Carolina, David Braff, La Jolla, Naomi California, Stephen Breslau, Washington Dager, Atlanta Druss, Susan Georgia, New Essock, New York, Ellen York, John Hardy, James Harris, Maryland Shitij Kapur, Kenneth Kendler, Virginia Ronald, C Kessler, Kathleen Merikangas, Maryland Samples O'malley, Michael Owen, Fmed Sci, Judith Rapoport, Maryland Charles, F Reynolds, Myrna Weissman, Naomi Wray, Charles Zorumski, St Louis, Roy Grinker Sr, Daniel Freedman, Jack Barchas, Joseph Coyle, Jennifer Urbano Blackford, Dost Öngür, Ira Phillips, Helena Chmura Kraemer, Howard Bauchner
Journal: JAMA Psychiatry (2015)
Population Toxicokinetics of Benzene
Authors: Frederic Yves Bois, Elise T. Jackson, Kaija Pekari, Martyn T. Smith
Journal: Environmental Health Perspectives (1996)

In assessing the distribution and metabolism of toxic compounds in the body, measurements are not always feasible for ethical or technical reasons.Computer modeling offers a reasonable alternative, but the variability and complexity of biological systems pose unique challenges in model building and adjustment.Recent tools from population pharmacokinetics, Bayesian statistical inference, and physiological modeling can be brought together to solve these problems.As an example, we modeled the distribution and metabolism of benzene in humans.We derive statistical distributions for the parameters of a physiological model of benzene, on the basis of existing data.The model adequately fits both prior physiological information and experimental data.An estimate of the relationship between benzene exposure (up to 10 ppm) and fraction metabolized in the bone marrow is obtained and is shown to be linear for the subjects studied.Our median population estimate for the fraction of benzene metabolized, independent of exposure levels, is 52% (90% confidence interval, 47-67%).At levels approaching occupational inhalation exposure (continuous 1 ppm exposure), the estimated quantity metabolized in the bone marrow ranges from 2 to 40 mg/day.
Nutrition: A Medical, Political, and Public Issue
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Congressional Office of Technology Assessment
Authors: J. Eden
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“Infertility in an adult cohort with primary ciliary dyskinesia: phenotype–gene association.” Gert Jan Vanaken, Laurence Bassinet, Mieke Boon, Rahma Mani, Isabelle Honoré, Jean-Francois Papon, Harry Cuppens, Martine Jaspers, Natalie Lorent, André Coste, Estelle Escudier, Serge Amselem, Bernard Maitre, Marie Legendre and Sophie Christin-Maitre.<i>Eur Respir J</i>2017; 50: 1700314.
Journal: European Respiratory Journal (2017)
Urticaria and sinusitis
Journal: JAMA (1981)

<h3>In Reply.—</h3> Referring to the letter by Dr Altman, in the 64 patients with chronic urticaria who had sinus x-ray examinations, there were abnormal radiological findings interpreted as sinusitis in 11 cases; three suggested chronic and eight acute involvement. The three cases interpreted as having chronic sinusitis all had substantial bilateral mucosal thickening of the maxillary sinuses, and one, in addition, had involvement of the ethmoid sinuses. The eight patients thought to have radiological evidence of acute sinusitis all had air-fluid levels in the maxillary sinuses. In one patient, the findings were bilateral; in seven, unilateral. We certainly agree that the literature cited by Dr Ravenel indicates that unsuspected abnormal radiological findings of the sinuses are encountered in asymptomatic young children. However, these studies have limited relevance to our article. Our study was intended to show a costbenefit effectiveness of a number of laboratory tests employed in the evaluation of
Spasmodic Torticollis
Authors: Bruce F. Sorensen
Journal: JAMA (1965)

Seventy-one patients, 43 men and 28 women, with spasmodic torticollis were treated surgically over an 18-year period. The average age at onset of symptoms was 43.2 years. No evidence was found to suggest a psychological origin of spasmodic torticollis. The etiology is organically based although the exact mechanism is not known. Conservative therapy benefited only five of the 66 patients preoperatively. The final objective results for the 70 surviving patients were as follows: no improvement in 4, minimal improvement in 7, moderate improvement in 22, and excellent improvement in 37. Anterior cervical rhizotomy and subarachnoid spinal accessory neurectomy should be the initial operation for spasmodic torticollis and if further surgical therapy is required, peripheral spinal accessory neurectomy is indicated. The findings in our series indicate that operation should be the primary treatment for spasmodic torticollis.
Abstract 2792: PD-1 modulates CD8+ T cell function in prostate tumor microenvironment
Authors: James Stokes, Eric Berry, Rajesh Singh, Upender Manne, Manoj K. Mishra
Journal: Cancer Research (2019)

Abstract In general, the Regulatory T (Treg) suppresses the immune response. However, their role and immunosuppressive mechanism(s) in context to programmed death 1 (PD-1) are not completely understood. This study aims to determine the role of PD-1 on Treg cells and their impact on CD8+ T cell function in prostatic tumor microenvironment using transgenic adenocarcinoma of the mouse prostate (TRAMP) cells (TRAMP C1, C2, and C3) as a model system. To execute the above aim, tumor induction studies were performed. Briefly, the C57BL/6 mice were administered with serial log concentrations of TRAMP (C1-3) cells. Interestingly, the TRAMP-C3 cells do not form a tumor, however, TRAMP-C1 and TRAMP-C2 cells do form a tumor. After tumor development, mice were sacrificed by cervical dislocation; tumor, lung, spleen, and draining lymph nodes were harvested when the tumor size reached approximately 20mm. Single cell suspensions were prepared from different organs, cells were then stained with specific antibodies, and flow analyzed for the expression of different immune markers. Our preliminary findings demonstrated that PD-1 expression on Foxp3+ Treg cells displayed greater suppressive capacity against CD8+ T cell function in tumor, lung, spleen, and draining lymph node when compared to the control. More importantly, Foxp3+ Treg(high) PD-1(high) interaction with PDL-1 induced immunosuppression by blocking CD8+ T cells function in the prostatic tumor microenvironment. Our data suggest that the expression of Foxp3 and PD-1 may enhance tumor progression; thus, targeting the PD-1 on Treg cells may be a possible therapy to treat prostate cancer. Note: This abstract was not presented at the meeting. Citation Format: James Stokes, Eric Berry, Rajesh Singh, Upender Manne, Manoj K. Mishra. PD-1 modulates CD8+ T cell function in prostate tumor microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2792.
Man and his cyclamate
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
无肌病性皮肌炎的诊断和分类
Authors: J.S.S. Concha, M. Tarazi, C.J. Kushner, R.G. Gaffney, V.P. Werth
Journal: British Journal of Dermatology (2019)

皮肌炎是一种炎症性疾病,具有特征性的皮损(受影响斑片)并伴有肌肉炎症和无力。一些人有肌肉变化但无皮肤表现(炎症性肌病),而一些人则只有皮损,可能从不发生肌肉炎症(无肌病性皮肌炎)。肌肉炎症分类的现有标准不能识别无肌病性皮肌炎。来自美国宾夕法尼亚大学的作者们使用 PubMed 数据库搜索了从 2018 年 6 月到 8 月期间关于无肌病性皮肌炎诊断和分类的医学文献(即,研究)。他们发现 226 篇关于诊断的文献和 32 篇关于分类的文献。现行识别皮肤特征的已验证标准未能纳入 25% 的患者。无肌病性皮肌炎可能在临床上(被医生)和组织学上(在显微镜下观察组织样本后)被误诊为另一种炎症性皮肤病(如皮肤型红斑狼疮)。诊断皮肌炎有重要意义,因为这些人存在炎症性肺病的风险更高,对于这些疾病,还应该筛查体内的癌症。作者们得出结论称,需要更具体的皮损描述和例如血液内是否存在自身抗体等额外信息来明确诊断,抗体是由免疫系统生成用于消灭疾病的,其中一些抗体只在特定类型的皮肌炎中发现。更精确的诊断将在未来实现更具针对性的治疗。
Short communications
Journal: British Journal of Dermatology (1996)

British Journal of DermatologyVolume 135, Issue s47 p. 65-66 Short communications First published: July 1996 https://doi.org/10.1111/j.1365-2133.1996.tb15176.xCitations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume135, Issues47July 1996Pages 65-66 RelatedInformation
Postmortem Homografts
Authors: Wilfred Tumbusch
Journal: JAMA (1960)

The authors in this text review the literature relative to postmortem homografting. They present clinical material which documents the life-saving potential of postmortem skin homografts in the management of patients with large areas of full-thickness skin loss. The advantage of homografts obtained postmortem versus antemortem grafts are discussed. On the basis of their vast experience in clinical and investigative skin transplantation in severely burned patients and animals, recommendations as to techniques of obtaining homografts, temporary or prolonged graft storage, and surgical methods of applying grafts are proposed. Reliable methods of skin storage and the "do's and don'ts" in the operation of a skin bank are discussed. The relationship of graft thickness, postmortem time of removal from the cadaver, freeze or non-freeze versus lyophilization methods of storage, media used during storage, rapid versus slow defreezing of grafts, and oxygen and antibiotic requirements to time of survival of homografts is clearly presented.