tbuckley/cabot-search huggingface dataset:
Enzyme Deficiency and Inherited Disorders
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Center for genetic research on scleroderma
Authors: A. A. Skolnick
Journal: JAMA (1997)

THE FIRST major center for the study of genetic and environmental factors that lead to the development of scleroderma has been established by a $2.5 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. The 4-year grant from this agency of the National Institutes of Health, Bethesda, Md, will support a multidisciplinary and multicenter assault on this littleunderstood but often fatal connective tissue disease, which affects an estimated 500 000 people in the United States. One of the main goals of the Specialized Center of Research in Scleroderma, headquartered at the University of Texas (UT) Medical School at Houston, is to map the genes responsible for at least the familial forms of the disease. According to the center's director, Frank C. Arnett, MD, professor and director of the Division of Rheumatology and Clinical Immunogenetics at UT-Houston, the center's research team will include more than 20 basic
Alcohol Variability and Blood Pressure: Results from the Usual Care Group of the Multiple Risk Factor Intervention Trial (MRFIT)
Authors: Deborah Chee, Jeremiah Stamler
Journal: Circulation (2001)

P84 Background: Previous studies suggest associations between pattern of alcohol consumption and blood pressure levels. However, there is little information on years-long patterns and blood pressure. Aim: Assess relationship of year-to-year variability in alcohol intake to blood pressure in alcohol users of the Usual Care (UC) group, Multiple Risk Factor Intervention Trial. Methods: 6,438 men from the MRFIT Usual Care group. Data on alcohol variability, blood pressure (BP) and confounding variables from five 24-hour dietary recalls and BP measurements at years 0,1,2,3, and 6. The intra-individual coefficient of variability (CV) in alcohol intake was computed for three sub-groups, defined by mean of reported intake: sub-group 1, less than 2 drinks/d; sub-group 2, 2-3 drinks/d; sub-group 3, more than 3 drinks/d. Multiple linear regression models --dependent variable blood pressure --were adjusted for mean alcohol intake, age, ethnicity, education, BMI, cigarette smoking, serum cholesterol, special diet, mean calories (in per day models), and mean dietary sodium and potassium intake. Results: Alcohol variability was inversely and significantly related to systolic and diastolic blood pressure in the whole group with alcohol expressed both as grams per day (e.g., for SBP: β= -0.026488, z=-2.132) and per cent energy (e.g., for SBP: β= -0.028594, z=-3.371). In sub-group 1 (n=5,128), the association was inverse but not significant; in sub-group 2 (n=1,073), the association was inverse and significant; in sub-group 3 (heavy drinkers) (n=237), the association was direct but not significant. Conclusions: Whereas year-to-year variability in reported alcohol intake was inversely related to blood pressure in men reporting less than 3 drinks/d, in heavy drinkers this evidence of erratic intake was associated with higher blood pressure.
THE SURGICAL TREATMENT OF ASCITES DUE TO CIRRHOSIS OF THE LIVER.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correlation between CD34 expression and chromosomal abnormalities but not clinical outcome in acute myeloid leukemia
Authors: Christophe Fruchart, Bernard Lenormand, Christian Bastard, Dominique Boulet, Jean‐François Lesesve, Marie‐Paule Callat, Aspasla Stamatoullas, Mathleu Monconduit, Herve Tilly
Journal: American Journal of Hematology (1996)
Increased levels of the soluble adhesion molecule E‐selectin in patients with chronic myeloproliferative disorders and thromboembolic complications
Authors: Caterina Musolino, Andrea Alonci, Alessandro Allegra, Giovanna Spatari, Giacomo Bellomo, Orazio Tringali, Cristina Quartarone, Giovanni Squadrito, Melchiorre Quartarone
Journal: American Journal of Hematology (1998)

Patients with chronic myeloproliferative disorders (CMD) show a high frequency of thrombosis. For this reason we evaluated endothelial cell markers, soluble adhesion molecule E-selectin (sELAM), and thrombomodulin (TM) in 25 patients with CMD. Among them nine presented thromboses in their past history. Data were compared with those obtained in a group of healthy subjects and a group of patients with secondary thrombocytosis. The mean plasma concentrations of sELAM were elevated in patients with CMD, as compared with healthy subjects (81.27 ± 42.8 ng/ml vs. 41.75 ± 13; P < 0.02). Similarly, the mean plasma concentrations of sTM were increased in CMD patients in comparison with the control group (102.0 ± 73 ng/ml vs. 16.7 ± 9.6; P < 0.01). More markedly elevated sELAM levels were observed in CMD patients with thrombosis than in patients without thrombosis (113.16 ± 29.5 ng/ml vs. 55.11 ± 19.1 ng/ml; P < 0.001), while no significant difference was found between CMD patients without thrombosis and secondary thrombocytosis (50.72 ± 10.8 ng/ml). Plasma thrombomodulin values in CMD patients with thrombosis (131 ± 93.8 ng/ml) were higher than those without thrombosis (65.77 ± 43.9 ng/ml; P < 0.02). sTM values were also significantly increased in patients with secondary thrombocytosis (P < 0.01). It is speculated that the plasma, sELAM levels may reflect endothelium activation and that it is possibly useful in predicting the thrombotic risk in myeloproliferative disorders. Am. J. Hematol. 57:109–112, 1998. © 1998 Wiley-Liss, Inc.
<i>Clinical Lectures on Mental Diseases.</i> By T. S. Clouston, M. D., Edin., F. R. C. P. E. Physician Superintendent of the Royal Edinburgh Asylum for the Insane, Lecturer on Mental Diseases in the Edinburgh University, etc., etc. London: J. &amp; A. Churchill. Philadelphia: Lea Brothers and Co.
Journal: American Journal of Psychiatry (1885)
NCCN News
Journal: Journal of the National Comprehensive Cancer Network (2020)

NCCN has announced this year's NCCN Annual Congress: Hematologic Malignancies will be fully online and open to all attendees at no cost.This annual gathering provides instruction from world-renowned experts for determining the best emerging techniques and practices for various blood cancers, including leukemia, lymphoma, and multiple myeloma.The virtual event will provide numerous opportunities for physicians, nurses, pharmacists, and other health professionals to earn continuing education credits, interact with experts, and network with peers.The NCCN Virtual Annual Congress: Hematologic Malignancies will take place on October 9-10, 2020, with the corresponding NCCN Virtual Nursing Forum taking place on October 8, 2020.The programs will include diagnostic and therapeutic advances, NCCN Guidelines updates, controversies in treatment, and currently salient topics such as: Navigating the Jargon of Molecular Testing, Implications of Biology on Treatment, Considering CAR T for All, Optimizing Outpatient Care, and Managing Cardiac Complications.The complete agenda can be viewed at NCCN.org/hem."The rapid pace of change in cancer care can pose challenges for clinicians trying to stay up-to-date on how to optimize patient outcomes," said event cochair Andrew D. Zelenetz, MD, PhD, Memorial Sloan Kettering Cancer Center."We're eager to reduce any knowledge and practice gaps by sharing information on the therapeutic advances that help us individualize treatment selection, minimize toxicities, and manage adverse events.""The NCCN Annual Congress for Hematologic Malignancies offers expert analysis of the latest clinical trial data," said co-chair Ranjana H. Advani, MD, Stanford Cancer Institute."Patients benefit when providers are well equipped to utilize cutting-edge guidelines.These comprehensive presentations, case studies, and interactive discussions will allow clinicians to stay abreast of advances in the evolving diagnostic and treatment landscape."The virtual format for the congress will provide opportunities for participants to engage with faculty in real-time and also include an online exhibit hall and breakout rooms for networking with colleagues."Our new platform allows us to make vital cancer information more accessible than ever, as we adjust for the ongoing COVID-19 pandemic," explained Robert W. Carlson, MD, Chief Executive Officer, NCCN."We look forward to having attendees from around the world and throughout the oncology ecosystem join us from the convenience of their home or office without the need for travel."Anyone who is not able to join the interactive sessions in real-time will have an opportunity to view recordings from the webcasts from November 1, 2020, through October 31, 2021, at education.nccn.org.A related Case of the Week series will also launch after the Congress.Join the conversation online with the hashtag #NCCNhem20.
Time Trends in Hospitalization and Discharge Status for Cirrhosis and Portal Hypertension in the United States
Authors: Peter Jepsen, Peter Ott, Per Kragh Andersen, Henrik Toft Sφrensen, Hendrik Vilstrup
Journal: Hepatology (2010)

We thank Dr. Talwalkar for his interest in our research. We previously published our analysis of Danish hospitalization rates for alcoholic cirrhosis between 1988 and 2005.1 Like Dr. Talwalkar, we found that the hospitalization rate had increased, but we also found that the number of hospitalizations per patient per year had increased (from 1.3 to 1.5 for men and from 1.1 to 1.2 for women). Thus, cirrhosis is placing an increasing burden on the health care system in Denmark as in the United States. Peter Jepsen M.D* , Peter Ott M.D , Per Kragh Andersen Ph.D. , Henrik Toft Sørensen Ph.D.*, Hendrik Vilstrup M.D. , * Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark, Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Aarhus, Denmark, Department of Biostatistics, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark.
Expanding possibilities.
Authors: O Fenton
Journal: BMJ (1987)

The first surgeon general9s report regarding oral health, Oral Health in America, called for a national effort to improve oral health among Americans and raised awareness of the importance of oral health; however, many Americans continue to experience poor oral health and are unable to access oral health care. Renewed national interest in oral health and access to oral health care through recent public policy documents and legislation presents a convergence of opportunities for the dental hygiene profession to continue to serve as a strong voice for the prevention of oral disease and the promotion of oral health for all segments of the population.
Abstract 1996: Epigenetic reactivation of BAI1/ADGRB1 suppresses tumor invasion by preventing TGFβ1-induced mesenchymal switch in glioblastoma
Authors: Satoru Osuka, Liquan Yang, Dan Zhu, Hideharu Hashimoto, Narra S. Devi, Erwin G. Van Meir
Journal: Cancer Research (2019)

Abstract Glioblastoma (GBM) is the most common and lethal type of malignant brain tumor in adults. GBM cells are highly invasive and diffusely infiltrate throughout the brain, which strongly restricts multimodal therapies. Acquiring a better knowledge of molecular defects underlying GBM invasion is essential for the development of effective therapies. Brain-specific Angiogenesis Inhibitor 1 (BAI1/ADGRB1) is a transmembrane receptor of the adhesion GPCR family widely expressed in normal brain, but its expression is lost in the majority of glioblastoma through epigenetic silencing and restoration of its expression can inhibit glioma growth (Zhu D. et al, Cancer Res, 2012). Recently, we reported that BAI1 protects p53 from Mdm2-mediated degradation and regulate tumor growth in medulloblastoma (Zhu D. et al, Cancer Cell, 2018). However, it is unclear whether BAI1 loss is important for tumor invasion and the mesenchymal phenotype in GBM. Microarray analysis of the GBM TCGA dataset revealed that low BAI1 mRNA expression correlates with poor outcome and with expression of many key mesenchymal genes, including Fibronectin1, SLUG, and TWIST1. Restoration of BAI1 expression in human GBM cells suppresses mesenchymal gene expression in culture, and dramatically decreases brain tumor invasion in mice xenografts. Mechanistically, we found that the N-terminal thrombospondin type 1 repeat (TSR#1) of BAI1 inhibits the maturation process of TGFβ1, a key growth factor involved in EMT. BAI1 is silenced epigenetically in GBM cells by methylated CpG-binding protein MBD2, and its expression can be reactivated by KCC-07, a blood-brain barrier permeable MBD2 inhibitor. We found that restoration of BAI1 expression by KCC-07 treatment dramatically reduced tumor cell invasion in orthotopic xenografts model of GBM cells. These experiments demonstrate that epigenetic silencing of BAI1 is important for activation of the GBM invasive phenotype through TGFβ1 pathway activation. Epigenetic targeting of this process by KCC-07 can reduce GBM invasion and improve patient survival. Citation Format: Satoru Osuka, Liquan Yang, Dan Zhu, Hideharu Hashimoto, Narra S. Devi, Erwin G. Van Meir. Epigenetic reactivation of BAI1/ADGRB1 suppresses tumor invasion by preventing TGFβ1-induced mesenchymal switch in glioblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1996.
Cyclopedia of the Diseases of Children. Medical and Surgical. The articles written especially for the work by American, British, and Canadian authors. Vol. v. Supplement.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rat Liver Endothelial and Kupffer Cell-Mediated Mutagenicity of Polycyclic Aromatic Hydrocarbons and Aflatoxin B 1
Authors: Pablo Steinberg, Birgit Schlemper, Elvira Molitor, Karl L. Platt, Albrecht Seidel, Franz Oesch
Journal: Environmental Health Perspectives (1990)

The ability of isolated rat liver endothelial and Kupffer cells to activate benzo(a)pyrene (BP), trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene (DDBP), trans-1,2-dihydroxy-1,2-dihydrochrysene (DDCH), and aflatoxin B, (AFB%) to mutagenic metabolites was assessed by means of a cell-mediated bacterial muta- genicity assay and compared with the ability of parenchymal cells to activate these compounds.Endothelial and Kupffer cells from untreated rats were able to activate AFB, and DDBP; DDBP was activated even in the absence of an NADPH-generating system.Pretreating the animals with Aroclor 1254 strongly enhanced the mutagenicity of the dihydrodiol, whereas the mutagenicity of AFB, showed a slight increase.BP and DDCH were only activated by endothelial and Kupffer cells isolated from Aroclor 1254-pretreated rats.Parenchymal cells from untreated animals activated all four carcinogens tested; Aroclor 1254 en- hanced the parenchymal cell-mediated mutagenicity of BP and DDCH but did not affect that of DDBP and clearly reduced that of AFB,.The reduced mutagenicity of AFB, correlates with the decrease in the amount of 2a-hydroxytestosterone formed when testosterone was incubated with parenchymal cell mi- crosomes from Aroclor 1254-pretreated rats (compared with microsomes from untreated animals): the formation of 2a-hydroxytestosterone is specifically catalyzed by cytochrome P-450h, a hemoprotein thought to be involved in the activation of AFB,.These results show that not only rat liver parenchymal cells, but also endothelial and Kupffer cells, activate several carcinogens to mutagenic metabolites.
Spinal anesthesia for hip pinning given with the patient supine
Authors: A. P. Winnie
Journal: JAMA (1969)

It is common practice when administering a spinal anesthetic to a patient with a fractured hip to give the anesthetic to the patient before moving him or her to the fracture table. This requires that the patient then be moved to the fracture table shortly after a chemical sympathectomy. The result is an excessively high incidence of hypotension; in this elderly and frequently debilitated group of patients, hypotension all too often does irreparable damage. By administering the anesthetic to the patient on the fracture table, the need to move the patient after the onset of anesthesia is avoided. This simple change in technique has been shown to reduce the incidence of hypotension by more than two thirds and the mortality by more than one half.
Infective Endocarditis
Authors: Jerry D. Smilack
Journal: JAMA (1993)

It is not a common condition: only some 5000 cases occur annually in the United States. Yet, infective endocarditis is as critical in the antibiotic era as in the days of Osler (perhaps more so, since specific curative treatment makes the diagnosis imperative). Up-to-date knowledge of the disease is compulsory, for endocarditis emerges in everyday practice as part of the differential diagnosis of the febrile patient or the patient with bacteremia. The newly published second edition of Donald Kaye's<i>Infective Endocarditis</i>arms the clinician with a reference that is at once comprehensive, readable, practical, and up to date. How valuable is echocardiography (transthoracic and transesophageal) in diagnosis and decision making? What are the optimal regimens for treatment of viridans streptococcal, enterococcal, and staphylococcal endocarditis? When is an abbreviated treatment regimen (a two-week antibiotic course) appropriate? Now that ampicillin-resistant and gentamicin-resistant strains of enterococci are being encountered, what is the recommendation
Intervertebral Disks
Authors: Nathaniel W. Faxon
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In the book,<i>The Massachusetts General Hospital</i>, 1935-1955, the chapter "What Are the Rewards of Research" states, "What follows is a partial account of the contributions of the staff of the Massachusetts General Hospital from 1900 to 1955." The section relating to intervertebral disks makes no claim as to priority of operation or publication. The original article, published in the<i>New England Journal of Medicine</i>, Aug. 2, 1934, was read by Drs. William Jason Mixter and Joseph S. Barr before the New England Surgical Society on Sept. 30, 1933, and was entitled "Rupture of the Intervertebral Disc with Involvement of the Spinal Canal." They reviewed the literature, giving credit to ten or more persons who had published articles. Dr. W. E. Dandy was included. It was also noted that Dr. Joel E. Goldthwaite, of the Massachusetts General Hospital staff, had reported a case in 1911 of posterior
Diabetes and Carbohydrates: The Copper Connection
Authors: Thomas E. Edes
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Bantle et al<sup>1</sup>show in a crossover study that after eight days on diets providing approximately 35% of energy as starch plus an additional 20% as fructose, sucrose, or starch, diabetics had lower plasma glucose levels when fructose was the added carbohydrate. Their work suggests that the source of dietary carbohydrates may affect glucose metabolism following food consumption. Interestingly, the animal literature has recently added copper as a new dimension to the carbohydrate/diabetes interaction. Reiser et al<sup>2</sup>have demonstrated that copper-deficient rats have significantly higher blood glucose levels after an oral glucose load compared with copper-supplemented rats. Adipocytes from copper-deficient rats bound less insulin than did cells from copper-fed rats, regardless of the carbohydrate source.<sup>3</sup> While copper deficiency may induce glucose intolerance, fructose feeding may induce clinical copper deficiency. Human subjects fed fructose as 20% of their diet developed biochemical evidence of decreased copper
Fifth European Antibiotic Awareness Day on 18 November - joining forces to reduce antibiotic resistance
Authors: Collective Eurosurveillance editorial team
Journal: Eurosurveillance (2012)

Preview this article: Fifth European Antibiotic Awareness Day on 18 November - joining forces to reduce antibiotic resistance, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/46/art20314-en-1.gif