tbuckley/cabot-search huggingface dataset:
Correction to: VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer
Authors: Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth, Florian Markowetz
Journal: Genome biology (2019)

Following publication of the original article [1], the authors reported that Figs. 4 and 5 had mistakenly been transposed. Please find the correct Figs. 4 and 5 below. The original article [1] has been corrected.
THE YELLOW FEVER GERM.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is the governance of the medical schools adequate to meet the new demands? Report of a Macy conference
Authors: J. Z. Bowers
Journal: JAMA (1968)

Governance is defined in<i>Webster's New International Dictionary, Second Edition</i>, as "Act, manner, office, or power of governing; government.... Method or system of government or regulation." If we apply this definition to medical schools we are not concerned solely with the dean. We include the trustees or regents; the president and his staff; vice presidents, the dean, department chairmen, faculty and external agencies, federal and private, that influence the decision-making process. My assignment is to present the reasons why the Macy Foundation became interested in the problems of governance, what we have done, and what we plan to do in the future. The medical schools have undergone what it is not an overstatement to call wrenching changes in the last 20 years. First, there has been an explosive growth in the variety and scale of programs. Second, there have been rapid changes in the character of the medical schools. They
Reply to Gopa Iyer, Bernard H. Bochner, Eliezer M. Van Allen, David B. Solit, and Jonathan E. Rosenberg's Letter to the Editor re: Russell E.N. Becker, Alexa R. Meyer, Aaron Brant, et al. Clinical Restaging and Tumor Sequencing are Inaccurate Indicators of Response to Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.07.016
Authors: Russell E.N. Becker, Alex Baras, Trinity J. Bivalacqua
Journal: European Urology (2020)
The gender gap in selection of cardiac transplantation candidates: bogus or bias?
Authors: T. Randall
Journal: JAMA (1993)

DOES gender bias influence the selection of cardiac transplant recipients? The raw numbers are certainly incriminating: Of the 2700 cardiac transplants performed worldwide in 1992, 81% of the recipients were men. But don't blow the political correctness whistle just yet. A retrospective study at one transplantation center found that 29% of all women accepted as transplant candidates over a 4.5-year period decided against the surgery, while only 9% of the men did. And when all the patients who refused transplantation but were otherwise qualified for the procedure were counted with the group that was accepted, the selection gender bias vanished. "It would appear, based on our preliminary data, that patients enrolled in transplant programs are selected on the basis of medical criteria only," says Keith Aaronson, MD, a research fellow in the division of cardiology at the University of Pennsylvania Medical Center in Philadelphia. The reason that women end up
Myocardial Gene Expression of Regulators of Myocyte Apoptosis and Myocyte Calcium Homeostasis During Hemodynamic Unloading by Ventricular Assist Devices in Patients With End-Stage Heart Failure
Authors: Babett Bartling, Hendrik Milting, Heike Schumann, Dorothea Darmer, Lativ Arusoglu, Michael Matthias Koerner, Aly El-Banayosy, Reiner Koerfer, Juergen Holtz, Hans-Reinhard Zerkowski
Journal: Circulation (1999)

Background —In patients with end-stage heart failure, characterized by an increased susceptibility to cardiomyocyte apoptosis and a labile cardiomyocyte calcium homeostasis, a ventricular assist device (VAD) is implanted for bridging to cardiac transplantation and results in myocardial unloading. Although phenotype changes in the failing heart are assumed to result from hemodynamic overload, the reversibility of these changes under unloading is unknown. Methods and Results —By use of quantitative reverse-transcription polymerase chain reaction, mRNA expression analyses were performed on left ventricular specimens obtained from 10 nonfailing donor hearts (from 8 patients with dilated cardiomyopathy and 2 patients with coronary heart disease) at the time of VAD implantation and 36 to 169 days later during VAD removal with subsequent cardiac transplantation. In terminally failing hearts before VAD support, left ventricular mRNA analyses revealed increased Pro-ANP, reduced antiapoptotic Bcl-x L and antiapoptotic Fas isoform FasExo6Del, and a decreased ratio of sarcoplasmic reticulum Ca 2+ -ATPase per sarcolemmal Na + -Ca 2+ exchanger in comparison with nonfailing ventricles. After VAD unloading, ventricular transcription of Pro-ANP was immediately normalized, and apoptotic DNA fragmentation was attenuated. In patients with dilated cardiomyopathy, mRNAs of Bcl-x L and FasExo6Del/Fas were enhanced depending on time on VAD. The Bcl-x L mRNA level correlated positively with that of the Bcl-x L protein. Transcription of sarcoplasmic reticulum Ca 2+ -ATPase/Na + -Ca 2+ exchanger demonstrated recovery in only 4 of 10 patients. Conclusions —Mechanical support of the failing heart induces a time-dependent change in myocardial gene expression compatible with a decreased susceptibility to apoptosis.
Brigade-Surgeon Andrew Barry
Journal: BMJ (1915)

He took part in the expedition against the Waghir tribes in 1865-66 ; in the operations of the Kathiawar Field Force in the Burdu Hills; in the Abyssinian campaign of 1867-68; and he was with the force which relieved Kandahar in the Afghanistan campaign of 1879-80.He received the medal in connection with both these latter campaigns.
Delayed Hypersensitivity
Authors: Max Samter
Journal: JAMA (1968)

"Delayed hypersensitivity" is an inflammation produced by small lymphocytes which—after sensitization to certain antigens—attack these antigens when they persist or return. Such antigens include small chemicals attached to carrier molecules, bacterial fragments, homografts, and heterografts. Fifty years ago, the function of lymphocytes was unknown; we know now that they are guardians of our integrity as a species. The small lymphocyte, the subject of this volume, not only carries the immunological memory of the host and instructs large lymphocytes to produce antibodies when antibodies are essential for survival, but it also has specific functions of its own. Small lymphocytes participate, as cells, in immunological reactions; unlike large lymphocytes, they do not release their antibodies, but carry them to the site of contact with the antigen. The book raises fundamental questions which are carefully worded, and provocative. Is it possible, for instance, to transfer sensitized small lymphocytes and, thus, delayed sensitivity from
Comparative effectiveness of everolimus versus endocrine monotherapies among post-menopausal women with HR+/HER2- metastatic breast cancer: A retrospective chart review of community oncology practices in the US.
Authors: Jipan Xie, Yanni Hao, Nanxin Li, Peggy L. Lin, Erika Ohashi, Valerie Koo, James E. Signorovitch, Eric Qiong Wu
Journal: Journal of Clinical Oncology (2015)

e11527 Background: Among post-menopausal women with hormone receptor-positive, human epidermal growth factor receptor-2-negative (HR+/HER2-) metastatic breast cancer (mBC), everolimus-based therapy (EVE) and endocrine monotherapies (ET mono) are commonly used. This study assessed the real-world comparative effectiveness of these treatments. Methods: A nationwide sample of post-menopausal HR+/HER2- mBC patients was identified in this retrospective chart review of community-based oncology practices. Patients were required to have received EVE or ET mono (index therapy) as any line of therapy for mBC during the period of July 2012 to April 2013, after failure of a non-steroidal aromatase inhibitor. Time on treatment (TOT), progression-free survival (PFS), and time to chemotherapy initiation (TTC), all measured from index therapy initiation, were compared using Kaplan-Meier analysis and Cox proportional hazards model adjusting for baseline characteristics. Results: A total of 243 patients treated with EVE and 270 patients treated with ET mono in a quota-based sample were included in the analysis. Upon initiation of index therapy, higher proportions of EVE treated patients had visceral metastases, high tumor burden, and prior chemotherapies for mBC than patients treated with ET mono. After adjusting for pre-treatment characteristics, EVE was associated with significantly longer TOT [hazard ratio (HR) = 0.67, 95% confidence interval (CI): 0.51 – 0.87] and PFS (HR = 0.75, 95% CI: 0.57 – 0.98) compared with ET mono. There was no significance difference between EVE and ET mono in TTC (HR = 0.81, 95% CI: 0.52 – 1.27). When further adjusted by interaction between line of therapy and treatment arms, adjusted HRs ranged from 0.48 to 0.82 for TOT, 0.62 to 0.89 for PFS, and 0.50 to 1.07 for TTC. Conclusions: In this retrospective chart review of post-menopausal HR+/HER2- mBC patients, treatment with EVE was associated with significantly longer TOT and PFS compared with ET mono.
Incidence of HCV infection among gbMSM in British Columbia, Canada: a population-based cohort study
Authors: Naveed Janjua, Stanley Wong, James Wilton, Prince Adu, Zahid Butt, Hasina Samji, Geoff McKee, Mawuena Binka, Younathan Abdia, Amanda Yu, Sofia Bartlett, Dahn Jeong, Emilia Clementi, Dr. Margo Pearce, Maria Alvarez, Dr. Jason Wong, Mel Krajden
Journal: Journal of Hepatology (2020)
Nitroglycerin Tablets: Loss of Potency
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hormonal Contraceptives Linked With Gestational Diabetes
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P193: A Cardiopulmonary Resuscitation Training Program for Family Members of In-Hospital Patients at Risk for Cardiac Arrest
Authors: Marion Leary, Lori Albright, Emily B Meshberg, Noah T Sugerman, Lance B Becker, Benjamin S Abella
Journal: Circulation (2008)

Background: Resuscitation from cardiac arrest often depends on prompt cardiopulmonary resuscitation (CPR) from the lay public, yet bystander CPR rates in the US are low. One barrier to bystander CPR delivery is that most arrests occur in the home, where only family members may be available to provide care. Little data exist regarding the ability to target and train family members of “at-risk” patients in CPR. Objective: We sought to implement a CPR video self-instruction (VSI) program for family members of in-hospital patients at risk for cardiac arrest. After training in situ before hospital discharge, we tested the hypothesis that at-risk patient family members would be motivated to secondarily train others in the home after leaving the hospital setting. Methods: Family members of patients hospitalized for cardiac conditions at one tertiary-care hospital between 12/07 and 6/08 who met pre-defined inclusion criteria were offered CPR VSI training requiring 25–30 min. All trainees were assessed for skill competence and video recorded for analysis. Trainees were encouraged to take the VSI kit home, and follow-up surveys were conducted to gauge secondary training of other family members. Results: Among 36 enrollees, mean age (SD) was 50 (13) and 78% of trainees were female; only 17% had been CPR trained within the past 10 years, and 44% had never been trained. Most (67%) of the trainees were either children or spouses of the at-risk hospitalized patients. Most (78%) trainees rated their experience with learning CPR via VSI as “comfortable” or “very comfortable”. During 2 min of CPR skills assessment, mean (SD) chest compression rate was 100 (19), mean percentage (SD) adequate depth was 89% (15%), and mean (SD) time for two breaths was 10.8 (4.6) sec. Follow-up surveys revealed that 33% of recipients performed secondary training at home, with a mean (SD) of 1.8 (1.3) secondary trainees. Conclusions: CPR VSI training for family members of hospitalized cardiac patients may serve as a cost-effective model to disseminate resuscitation skills and allows for secondary training in the home of patients at risk for sudden cardiac arrest.
Headache
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STREPTOCOCCIC ENZYMATIC DEBRIDEMENT
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A computer-based medical record. Entry of data from the history and physical examination by the physician
Authors: J. M. Kiely
Journal: JAMA (1968)

The Mayo Clinic has had preliminary experience with a computer-input system which employs video screen and light-pen and allows the physician to use ordinary English language for entry and retrieval of historical and physical-examination data. The system allows the clinician convenient, rapid, direct interaction with a computer-based, medical-information system. Use of this technique results in clinical records that are carefully formatted, complete and legible, and easily retrievable either on the video screen or as printed copy. These improved attributes of the clinical record should result in better patient care and facilitate retrieval of data for clinical research.
Comparison of the 'Open' vs 'Closed' Intensive Care Unit Formats
Authors: Geoffrey Wittig
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The article by Carson et al<sup>1</sup>strongly implies that care was better under the closed ICU system because of a nonsignificant trend in mortality. One could just as easily conclude otherwise; the mortality among patients requiring mechanical ventilation was higher (46.8% vs 34%) under the closed system. Intensive care unit nurses felt more comfortable working solely with dedicated ICU physician staff, but this is only to be expected and does not make a valid outcome measure. I suspect the greater mean APACHE II score of patients during the closed trial reflected reluctance among primary physicians to relinquish care of "borderline" patients to the ICU staff. One wonders if net hospital mortality did not increase among relatively sick patients kept in the regular medical units. Mandating the transfer of ICU patients to critical care specialists may improve short-term outcomes; as a primary care physician, I am well aware of my
Decrease in Pulmonary Metastases: Potentiation of Nitrogen Mustard Effect by Heparin and Fibrinolysin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for nonproteolytic activation of prorenin
Authors: Atsuhiro Ichihara, Matsuhiko Hayashi, Yuki Kaneshiro, Fumiaki Suzuki, Tsutomu Nakagawa, Yuko Tada, Yukako Koura, Akira Nishiyama, Hirokazu Okada, M. Nasir Uddin, A.H.M. Nurun Nabi, Yuichi Ishida, Tadashi Inagami, Takao Saruta
Journal: Journal of Clinical Investigation (2004)

We found that when a site-specific binding protein interacts with the “handle” region of the prorenin prosegment, the prorenin molecule undergoes a conformational change to its enzymatically active state. This nonproteolytic activation is completely blocked by a decoy peptide with the handle region structure, which competitively binds to such a binding protein. Given increased plasma prorenin in diabetes, we examined the hypothesis that the nonproteolytic activation of prorenin plays a significant role in diabetic organ damage. Streptozotocin-induced diabetic rats were treated with subcutaneous administration of handle region peptide. Metabolic and renal histological changes and the renin-Ang system components in the plasma and kidneys were determined at 8, 16, and 24 weeks following streptozotocin treatment. Kidneys of diabetic rats contained increased Ang I and II without any changes in renin, Ang-converting enzyme, or angiotensinogen synthesis. Treatment with the handle region peptide decreased the renal content of Ang I and II, however, and completely inhibited the development of diabetic nephropathy without affecting hyperglycemia. We propose that the nonproteolytic activation of prorenin may be a significant mechanism of diabetic nephropathy. The mechanism and substances causing nonproteolytic activation of prorenin may serve as important therapeutic targets for the prevention of diabetic organ damage.
Ibrutinib Treatment Mitigates Phenotypic Alterations of Non-Neoplastic Immune Cell Compartments in Chronic Lymphocytic Leukemia
Authors: Valentina Griggio, Candida Vitale, Maria Todaro, Francesca Romana Mauro, Chiara Salvetti, Daniela Pietrasanta, Iolanda Donatella Vincelli, Lydia Scarfo, Giovanni Del Poeta, Gianluca Gaidano, Valter Gattei, Robin Foà, Mario Boccadoro, Marta Coscia
Journal: Blood (2018)