tbuckley/cabot-search huggingface dataset:
Medicare Funding of Graduate Medical Education
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1974)

<h3>Six years and 12,000 men: some answers to heart disease</h3> ? Can an "active intervention" program persuade middle-aged men to reduce their serum cholesterol, blood pressure, and cigarette smoking—and thus reduce their death rate from coronary heart disease? This is the basic question to be answered by a massive, long-term study getting underway at 20 clinical centers in the United States. The six-year study is sponsored by the National Heart and Lung Institute. Approximately 12,000 volunteer men are being recruited. All will be apparently healthy, and between the ages of 35 and 57—but all will have one or more of the risk factors, that is, elevated serum cholesterol, hypertension, or the habit of smoking cigarettes. Half the men will be randomly assigned to "intervention programs" designed to persuade them to do such things as change their diets and stop or cut down on their smoking. The rest will be referred to
Acute Myocardial Infarction
Authors: Robert Goldberg
Journal: JAMA (1979)

A community-wide study was conducted in metropolitan Baltimore in which the prognosis of 330 patients hospitalized with an acute myocardial infarction (MI) complicated by ventricular fibrillation or cardiac arrest (VFib/CA) was compared with that of 1,071 patients hospitalized with acute MI not complicated by VFib/CA. As expected, the in-hospital case-fatality rate among patients with MI complicated by VFib/CA was significantly higher than that in patients without VFib/CA. However, for patients discharged alive from the hospital, no significant differences in long-term survival were found between patients with MI with or without VFib/CA. These results suggest that attempts at preventing subsequent mortality should be diligently pursued in patients with MI who are discharged alive from the hospital regardless of the occurrence of VFib/CA in the acute phase. (<i>JAMA</i>241:2024-2027, 1979)
Diet, Nutrition, and Avoidable Cancer
Authors: Walter C. Willett
Journal: Environmental Health Perspectives (1995)

In a 1981 review, Doll and Peto estimated that approximately 35% of cancer deaths in the United States were potentially avoidable by the modification of diet but that this percentage might be as low as 10% or as high as 70%.Since that time, the epidemiologic literature on diet and cancer has grown greatly, as has understanding of the mechanisms of carcinogenesis.In general, this expanded literature has not provided reason to alter the Doll and Peto estimate substantially.For colon cancer, evidence has accumulated that some of the international differences that were attributed to diet are probably due to physical activity.For breast cancer, the concept that fat intake per se is the primary reason for differences in rates among countries has not been supported by prospective studies.Although several lines of evidence suggest that caloric restriction and slow growth rates may contribute importantly to the low rates of breast cancer found outside Western countries, this may not translate directly to practical means of prevention.In contrast to breast cancer, more recent data have supported a causative role for red meat in the development of colon and prostate cancers, although perhaps not entirely due to its fat content.Whereas earlier thinking about nutrition and cancer emphasized the adverse effects of fat and other components in the diet, the most compelling evidence of the last decade has indicated the importance of protective factors, largely unidentified, in fruits and vegetables.Considering the more recent evidence, it is roughly estimated that about 32% of cancer may be avoidable by changes in diet; however, it now seems unlikely that less than 20% or more than 42% of cancer deaths would be avoidable by dietary
SUBPERIOSTEAL HEMATOMA IN RICKETS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treating the Stomach: Cocaine and Potatoes
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dantrolene Hepatitis
Authors: Philip Assatourians
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In a recent article (235:1590, 1976), Drs Schneider and Mitchell present a case of cholestatic jaundice that most likely is secondary to dantrolene therapy. I think their conclusion that "initially obstructive jaundice was... the most likely diagnosis in this patient because of the high serum bilirubin level, relatively low serum levels of transaminase, the negative reaction for HB<sub>s</sub>Ag..." is incorrect. As a matter of fact, this is a classic chemical pattern of intrahepatic cholestatic jaundice, and liver biopsy should have been considered as the first invasive procedure. Any student of hepatology knows that total bilirubin levels in extrahepatic jaundice rarely exceed 15 mg in stone disease and 25 to 30 mg in cancer. Levels of 50 mg are almost always indicative of intrahepatic disease unless there is a severe ascending cholecystitis; the alkaline phosphatase, if anything, is more compatible with intrahepatic disease and certainly not
Abortion Practice
Authors: Gordon M. Ditmanson
Journal: JAMA (1985)

Much of the literature about abortion in the last ten years has been epidemiologic or methodological in content, supplemented by monographs on its legal, sociological, or political aspects. There have also been ancedotal references to its morbidity and mortality, pathology, instrumentation, and variation in technique. In<i>Abortion Practice</i>(JB Lippincott Co, 1984) Dr Warren Hern has offered one of the first practical manuals dealing with all aspects of the clinical practice of abortion. Dr Hern is well qualified to write such a text, having some of the most extensive experience of anyone providing the service today. In addition, his teachers and mentors, who are appropriately identified in the book, are the pioneers and leading experts in the field. The 13 chapters in this book include the epidemiologic foundations of abortion, patient screening and counseling, nursing, operative procedures, postoperative care and management of complications, diagnostic evaluation of pregnancy, equipment, facilities, staffing,
Biotransformation of Xenobiotics in Human Intestinal Mucosa
Authors: H. P. Hoensch, R. Hutt, F. Hartmann
Journal: Environmental Health Perspectives (1979)

Drug-metabolizing enzymes, especially monooxygenases, play a major role in biotransformation and detoxification of many foreign compounds including environmental carcinogens. Although largely localized in the liver they are also found in the small intestine, which is the portal of entry of dietary toxins. Therefore cytochrome P-450 content as well as monooxygenase (7-ethoxycoumarin O-deethylase) and NADPH-cytochrome c reductase activities were determined in surgical specimens of the human small intestine and in jejunal biopsy material obtained from patients by use of a hydraulic biopsy instrument. Microsomes were prepared from surgical material; these ranged in P-450 content from 30 to 120 pmole/mg protein and in monooxygenase activity from 60 to 110 pmole/min-mg protein. In the 20,000g supernatant of the homogenized biopsy material, monooxygenase activity was undetectable in patients who had total villous atrophy, and low enzyme rates were found when the mucosa showed a partial villous atrophy. The mucosal monooxygenase activity of patients with normal jejunal histology and steatorrhea was significantly higher than in mucosa with villous atrophy but was only half of that observed in normal controls. These eight control patients had normal histology and no malassimilation. Our results suggest that monooxygenase activity in the human small intestine is dependent on the morphological integrity of the mucosa and that in normal mucosa the enzyme rates are reduced when malassimilation is present.
Degos' Disease (Malignant Papulosis)
Authors: Henry H. Roenigk
Journal: JAMA (1968)

Three patients with Degos' disease (malignant papulosis) were seen at the Cleveland Clinic. The course of the first patient's disease was typical with cutaneous, gastrointestinal, and systemic involvement and death. The other two patients survived despite the typical cutaneous lesions. Abnormalities of the immunoglobulin fraction IgA were present, as well as an abnormal fibrinogen value. However, there appears to be no direct relationship to periarteritis nodosa or other forms of vasculitis and the cause of Degos' disease remains unknown.
Surgical Reconstruction of the Aortic Valve
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent events of special interest to medical education
Authors: C. H. Ruhe
Journal: JAMA (1980)

Since 1966, Section I of theEducation Numberhas been devoted to a review of "Recent Events of Special Interest to Medical Education." Information has been included about special studies, reports, legislation, and other events and activities that are related to medical education and may be expected to influence its future course and direction. The trends identified in last year's report continue to be prominent. Cost containment remains a major issue and appears to influence virtually all proposed federal legislation and regulation in the health field. In addition, much proposed state legislation appears to be motivated by the desire to restrain increasing costs in the health field. The combined impact of legislative proposals at the federal and state levels continues to move slowly in the direction of greater and greater restriction of the independence of individual health practitioners and increasing demand for public accountability. A major development was the withdrawal
Correction: Cardiac transplantation in severely ill patients requiring intensive support in hospital
Authors: R Gray, J Menage, D Cook, J Harcourt
Journal: BMJ (1988)

of the six cases ofeye injuries caused by elasticated straps Case Age Circumstances in which injury Visual acuity No (years) Sex occurred Clinical findings Management (months after injury) 1 11 M Fastening strap on trailer tent Hyphaema Bed rest 6/6 (1) 2 41 M Strapping load across lorry Corneal perforation Suturing of cornea 6/18 (3) 3 39 M Pulling strap on windsurfer Iris tear, hyphaema, vitreous haemorrhage, Bed rest, ocular hypotensives 6/18 (3) secondary glaucoma 4 63 M Fastening strap over car roof rack Hyphaema, post-traumatic cataract Bed rest, delayed surgery for cataract and 6/9 (3 months after surgery) implantation of intraocular lens 5 50 M Fastening strap over car roof rack Iris tear, retinal detachment Vitrectomy and injection of silicone oil 6/60 (8) 6 31 M Fastening strap over car roof rack Hyphaema, retinal tear Bed rest, cryotherapy to retinal tear 6/9 (1))leads would prevent accidental release.Only one hook would need to be so modified provided instructions were given to secure the gated hook first.Manufacturers should be encouraged to enclose safety warnings with elasticated straps, and the public needs to know about their potential risk.We thank the consultant staff of this hospital for permission to report on these patients.
MECHANISM OF CARIOSTATIC ACTION OF FLUORIDE
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract C31: Characterization of malignant melanoma growth triggered by the brain microenvironment in experimental metastasis models
Authors: Vigdis Nygaard, Lina Prasmickaite, Kotryna Vasiliauskaite, Trevor Clancy, Eivind Hovig
Journal: Cancer Research (2013)

Abstract Melanomas are particularly renowned for their plasticity in response to microenvironmental signals. The brain offers a unique microenvironment to which malignant melanoma frequently spreads leading to dismal prognosis for the patients. The aim of our study was to reveal characteristics of metastatic growth of melanoma in the brain by in vivo imaging, cellular characterization and molecular approaches. The study was based on experimental metastasis models in vivo established from the melanoma cell lines, Melmet 1 and Melmet 5 with opposing phenotypes (invasive/proliferative, respectively) in the in vitro setting and distinct metastatic patterns in vivo. Gene expression profiling of brain metastatic cells isolated from different growth phases revealed the dynamic and opportunistic nature of melanoma in this context. We detected transitioning from the invasive phenotype to the proliferative phenotype, as the brain metastases passed from early to late growth phase. We also identified the existence of a neuron-like phenotype which included synaptic characteristics and a neurotransmission-like circuit involving glutamate receptors. This brain-adaptive phenotype was more prominent in the earlier metastatic growth phases compared to a later phase. To uncover microenvironmental factors that could play a role in melanoma cell colonization of the brain, we analyzed gene expression in host stroma. Genes implicated in immune-/inflammatory-responses were up-regulated and cellular characterization of metastatic brain tissue revealed the emergence and accumulation of cells of bone-marrow origin like microglia (F4/80+, CD11b+) that correlated with “active growth” phase initiation. Altogether, this suggests that acquisition of the brain-adaptive phenotype in a cooperative inflammatory environment might be critical for the establishment of metastatic growth in the brain microenvironment. Global network modeling and functional annotation analysis revealed that several of the central molecular factors and pathways mediating melanoma brain metastasis in this study, are also central to other pathological diseases, in particular neurodegenerative diseases. The identification of essential molecular networks that operate to promote the brain-adaptive phenotype is of clinical relevance, as they represent leads to urgently needed therapeutic targets. Citation Format: Vigdis Nygaard, Lina Prasmickaite, Kotryna Vasiliauskaite, Trevor Clancy, Eivind Hovig. Characterization of malignant melanoma growth triggered by the brain microenvironment in experimental metastasis models. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr C31.
Health services and public health (Abstract No. 456-466)
Authors: Nebojsa Manojlovic, Ivana Filipovic, Jeremija Josifovski, Abdullah Buyukcelik, Dilek Dincol, Mustafa Samur, Hakan Akbulut, Ahmet Demirkazik, Cay Filiz, Handan Onur
Journal: Annals of Oncology (2002)
Der heutige Stand der Lehre von den Geschwülsten im besonderen der Carcinome.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sex-Hygiene: What to Teach and How to Teach It
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal