tbuckley/cabot-search huggingface dataset:
Treatment of Acute Stanford Type B Aortic Dissection With a Novel Cylindrical Balloon Catheter in Dogs
Authors: Hiromu Terai, Nobushige Tamura, Tatsuo Nakamura, Kazunobu Nishimura, Norimasa Tsutsui, Yasuhiko Shimizu, Masashi Komeda
Journal: Circulation (2000)

Background —Despite recent progress in medical and surgical treatment, acute type B aortic dissection still carries a high mortality rate. We have developed a novel cylindrical balloon catheter for less invasive treatment to block the entry of the dissection and induce thrombotic occlusion of the false lumen. The balloon has the shape of a sheet when deflated but a double-cylinder shape when inflated. Therefore, aortic blood flow is maintained through the cylindrical lumen during balloon inflation. Methods and Results —Six beagle dogs underwent a left thoracotomy at the 6th intercostal space. An acute dissection of 4-cm length was created surgically on the descending aorta. The balloon catheter was inserted through the distal descending aorta and advanced to the entry site. The balloon catheter was inflated for 6 hours. The blood flow in the descending aorta and the position of the balloon was monitored by color Doppler echovasculography. Four dogs were killed humanely on the following day and 2 dogs 10 days after the surgery. The descending aorta was examined macroscopically and microscopically in all dogs. In all dogs, the false lumen was occluded by thrombi. Although no dog had clinical evidence of distal thromboembolism, 2 of the 4 dogs that were killed on the second postoperative day had fresh mural thrombi in the true lumen. Conclusions —The false lumen of the acute type B aortic dissection was effectively occluded by the novel cylindrical balloon catheter in the canine experimental model. The thrombus formation in the true lumen is the problem to be solved.
Acute epiglottitis
Authors: R. Charles, M. Fadden, J. Brook
Journal: BMJ (2013)

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Radiation Research, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Value of Antibiotic Prophylaxis during Extracorporeal ShockWave Lithotripsy in the Prevention of Urinary Tract Infections in Patients with Urine Proven Sterile prior to Treatment
Authors: A.F. Bierkens, A.J.M. Hendrikx, K. Ezz El Din, J.J.M.C.H. de la Rosette, A. Horrevorts, W. Doesburg, F.M.J. Debruyne
Journal: European Urology (1997)
Human Matrix Metalloproteinase-8 Gene Delivery Increases the Oncolytic Activity of a Replicating Adenovirus
Authors: Jin Cheng, Harald Sauthoff, YaoQi Huang, David I Kutler, Sofia Bajwa, William N Rom, John G Hay
Journal: Molecular Therapy (2007)

The success of replicating adenoviruses for cancer therapy is limited by inefficient virus delivery and poor distribution within the tumor mass. Stromal matrix within the tumor may hinder the free cell-to-cell spread of the virus. In this study, in vitro cell culture experiments showed that collagen I blocked the passage of an adenoviral vector through a membrane. On the basis of reports of the effective collagen I–degrading activity of matrix metalloproteinase-8 (MMP-8), we constructed an adenovirus to express the MMP-8 transgene (AdMMP8). A549 cells infected in vitro with AdMMP8 did not show altered growth but were able to modify a fibrillar collagen substrate to allow viral diffusion. Further, AdMMP8 did not affect replication of the wild-type virus (Adwt300). Established human A549 lung cancer and BxPC-3 pancreatic cancer xenograft tumors that were injected with Adwt300 together with the non-replicating AdMMP8 virus showed significantly reduced growth compared with control tumors. Histochemical analysis showed reduced amounts of collagen within necrotic areas of MMP-8-injected tumors compared with controls. These results demonstrate that intra-tumoral expression of MMP-8 is a possible strategy for improving viral spread and improving the oncolytic activity of replicating adenovirus. The success of replicating adenoviruses for cancer therapy is limited by inefficient virus delivery and poor distribution within the tumor mass. Stromal matrix within the tumor may hinder the free cell-to-cell spread of the virus. In this study, in vitro cell culture experiments showed that collagen I blocked the passage of an adenoviral vector through a membrane. On the basis of reports of the effective collagen I–degrading activity of matrix metalloproteinase-8 (MMP-8), we constructed an adenovirus to express the MMP-8 transgene (AdMMP8). A549 cells infected in vitro with AdMMP8 did not show altered growth but were able to modify a fibrillar collagen substrate to allow viral diffusion. Further, AdMMP8 did not affect replication of the wild-type virus (Adwt300). Established human A549 lung cancer and BxPC-3 pancreatic cancer xenograft tumors that were injected with Adwt300 together with the non-replicating AdMMP8 virus showed significantly reduced growth compared with control tumors. Histochemical analysis showed reduced amounts of collagen within necrotic areas of MMP-8-injected tumors compared with controls. These results demonstrate that intra-tumoral expression of MMP-8 is a possible strategy for improving viral spread and improving the oncolytic activity of replicating adenovirus.
Cerebral Hyponatremia
Authors: Franklin H. Epstein, Howard Levitin, Gilbert Glaser, Paul Lavietes
Journal: New England Journal of Medicine (1961)

WHEN water retention is induced in a normal person by the administration of exogenous antidiuretic hormone, the serum sodium falls, and the renal excretion of sodium increases.1 Inappropriate release of endogenous vasopressin has been suggested as the cause of hyponatremia and renal salt wasting in certain diseases, including bronchogenic carcinoma,2 3 4 cerebral injuries5 , 6 and malformations7; it is probably also responsible for hyponatremia in tuberculous meningitis.8 , 9 Inability to excrete water normally is also a feature of the salt wasting of certain hyponatremic patients with pulmonary tuberculosis.10 The present report concerns a young woman in whom chronic hyponatremia was associated over a . . .
Defibrillator Accidents
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New computer revolutionizes writing
Authors: J. S. Gravenstein
Journal: JAMA (1968)

The following is the first report on a new computer, called Hyperbroca, which is capable of translating one English style into another. This unit will affect all writing, in science as well as in fiction. I shall present a brief history of the computer's development, a sample of what the machine can do, and a preview of the changes it might bring and the problems it might produce. Late in 1958 the directors of the Association of University Authors (AUA) appointed a committee of seven to "study the difficulties inherent in and detracting from multiple author texts (MATs)." Each member of this committee had not only published the required 110 papers, but had also contributed to at least four MATs. Three years later the committee made its report. A single dissenting member wrote a minority report, which merely stated that no inherent difficulties exist with MATs and that careful selection
Hydrops Fetalis
Authors: Shirley G. Driscoll
Journal: New England Journal of Medicine (1966)

INNOVATIONS in management of hemolytic disease of the newborn promise salvage of some otherwise doomed infants by judicious choice of dates of delivery and perinatal treatment.1 , 2 The advent of fetal transfusion presages an era of more complex therapeutic manipulations of the young fetus while he is still sheltered within the uterus. When hydrops develops, these measures are almost always futile. It appears that the administration of immune globulin to the mother immediately after delivery prevents initial sensitization to the Rhesus antigen.3 , 4 However, universal application of this prophylactic procedure cannot be expected for some years. Furthermore, many women of childbearing age . . .
Apolipoprotein (Apo) E4 genotype is associated with increased risk of cholesterol (XOL) gallstone recurrence after shock-wave lithotripsy (ESWL) . Dept. Gastroenterology1 &amp; Internal Medicine2, University Hospital Ultrecht, The Netherlands. Istituto di Clinica Medica I, University Medical School Bari, Italy
Journal: Hepatology (1995)
Abstract P038: Associations of Plasma Phospholipid and Dietary Alpha Linolenic Acid with Mortality, Coronary Heart Disease and Stroke in Older Adults: The Cardiovascular Health Study
Authors: Amanda M Fretts, Dariush Mozaffarian, David Siscovick, Colleen Sitlani, Bruce M Psaty, Eric B Rimm, Xiaoling Song, Barbara McKnight, Donna Spiegelman, Irena B King, Frank M Sacks, Rozenn Lemaitre
Journal: Circulation (2013)

Objective: To examine the association of α-linolenic acid (ALA 18:3n-3), an essential n-3 fatty acid derived from plants and vegetable oils, with mortality, coronary heart disease, and stroke among older adults. Due to the low correlation between dietary and circulating ALA that may reflect differences in diet and metabolism, we evaluated plasma phospholipid ALA and dietary ALA separately. Methods: The study population included participants from the Cardiovascular Health Study, a community-based longitudinal cohort of adults aged 65 or older, free of prevalent coronary heart disease and stroke. A total of 2,709 participants comprised the plasma phospholipid analysis group and 4,214 participants comprised the dietary analysis group. Plasma phospholipid ALA, an objective measure of circulating levels of ALA over the past 4-8 weeks, was measured using stored samples from 1992-1993. Dietary fatty acid intake was ascertained using food frequency questionnaires administered in 1989 and 1996. ALA was expressed as percent of total fatty acids and percent of total dietary fat for the plasma phospholipid and dietary analyses, respectively. Cox regression was used to assess the associations of plasma phospholipid and dietary ALA with mortality, and incident coronary heart disease or stroke. Results: Dietary ALA and plasma phospholipid ALA were modestly correlated (r=0.18). We found no statistically significant associations of plasma phospholipid ALA with mortality, incident CHD or stroke (table). After adjustment for potential confounders, dietary intake of ALA was associated with a lower risk of total and non-CVD mortality. We found no statistically significant associations of dietary ALA with CVD mortality, incident CHD or stroke (table). Conclusions: Results from this prospective cohort study of older adults suggest that dietary, but not plasma phospholipid ALA, is associated with a lower risk of total and non-CVD mortality in older adults.
Diagnostic specificity of Widal's reaction for typhoid fever
Authors: D. W. Reynolds
Journal: JAMA (1970)

A positive Widal's reaction developed in a 2-year-old girl following nontyphoid Salmonella gastroenteritis. Recent data from the Center for Disease Control suggest that false-positive Widal reactions following certain nontyphoid Salmonella infections may occur commonly. Antigens common to Salmonella groups A, B, and D account for this cross-reacting antibody.
OP0160-HPR Determinants of happiness and quality of life in patients with rheumatoid arthritis: a structural equation modelling approach
Authors: E Santos, C. Duarte, R. Ferreira, A.M. Pinto, R. Geenen, J.A.P. da Silva
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Remission is the core target of disease management in rheumatoid arthritis (RA), but the ultimate goal of medical care is to improve patients’ enjoyment of life, a concept akin to happiness. What is the contribution of disease control towards happiness and what other means may the health professional consider towards that goal? <h3>Objectives</h3> To examine the determinants of happiness and quality of life (QoL) in patients with rheumatoid arthritis (RA), with emphasis on disease activity, disease impact and personality traits. <h3>Methods</h3> This is an ancillary analysis of an observational, cross-sectional study. Consecutive patients were assessed on disease activity, disease impact, personality, QoL and happiness. Structural equation modelling estimation was used to assess the associations between these dimensions, pursuing three hypotheses: H<sub>1</sub> – Disease activity and perceived impact of disease are negatively associated to overall QoL and happiness in patients with RA; H<sub>2</sub> – ‘Positive’ personality traits are related to happiness both directly and indirectly through perceived disease impact; H<sub>3</sub> – Happiness has a mediating effect in the relation between impact of disease and QoL. <h3>Results</h3> Data from 213 patients was analysed. Results obtained in the structural equation measurement model indicated a good fit [χ<sup>2</sup>/df=1.38; CFI=0.98; GFI=0.92; TLI=0.97; RMSEA=0.04] and supported all three driving hypotheses (figure 1). Happiness was positively related to ‘positive’ personality (total effect of 0.56, with a direct effect of β=0.50, p&lt;0.001 and an indirect effect of β=0.06, p=0.03) and, to a lesser extent, negatively related with perceived impact of disease (<i>β</i>=-0.17; p=0.02). This impact, in turn, was positively related to disease activity (<i>β</i>=0.36; p&lt;0.001) and mitigated by ‘positive’ personality traits (<i>β</i>=-0.37; p&lt;0.001). Impact of disease had a much stronger relation with QoL than with happiness (total effect of 0.72, of which β=-0.02, p=0.04 was an indirect effect vs <i>β</i>=-0.17; p=0.02, respectively). Happiness mitigated the negative effect of disease impact upon QoL (<i>β</i>=0.13; p=0.01). Moreover, disease activity had a negative indirect effect of −0.26 (p=0.003) on QoL and also a negative indirect effect of <i>β</i>=-0.06 (p=0.04) on happiness. <h3>Conclusions</h3> Optimisation of QoL and happiness of people with RA requires not only effective control of the disease process but also improvement of the disease impact domains. Personality, and its effects upon the patient’s perception and experience of life, seems to play a pivotal mediating role in these relations and should deserve paramount attention if happiness and enjoyment of life is taken as the ultimate goal of health care. <h3>Disclosure of Interest</h3> None declared
Smoking and drinking during pregnancy. Their effects on preterm birth
Authors: P. H. Shiono
Journal: JAMA (1986)

The effects of cigarette smoking and alcohol consumption on the length of gestation were examined in a prospective study of 30,596 pregnant women in northern California. Preterm births (&lt;37 weeks' gestation) were 20% more common in women smoking at least one pack of cigarettes per day. This effect was strongest for births occurring before 33 weeks, where the excess was 60%. This excess was not accounted for by differences in maternal age, education, ethnicity, time prenatal care began, drinking during pregnancy, or eight other potential confounding factors. The results indicate a probable effect of smoking on the time of parturition, which is additional to its well-known effect on intrauterine growth retardation. The effect of alcohol consumption on preterm births was also examined, but no consistent trends were found. (<i>JAMA</i>1986;255:82-84)
Sudden cardiac death in Air Force recruits. A 20-year review
Authors: M. Phillips
Journal: JAMA (1986)

We reviewed the clinical and autopsy records of the 19 sudden cardiac deaths that occurred among the 1 606 167 US Air Force healthy, medically screened recruits (90% male; 17 to 28 years old) during a 42-day basic training period between 1965 and 1985. Sixteen (all male) died suddenly of underlying structural heart disease, whereas no anatomic cause of death was identified in the remaining three. Thirty-two nonsudden, noncardiac deaths occurred during the same period, and only two had structural heart disease. Strenuous physical exertion was associated with sudden death in 17 of 19 cases (0.017 deaths per 50 000 exercise-hours), and the most frequent underlying etiology was myocarditis. Sudden cardiac death, a rare event in healthy young adults, is usually associated with exertion. (<i>JAMA</i>1986;256:2696-2699)
Coffee and Protein Metabolism
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rat-Bite Fever—New Mexico, 1996
Journal: JAMA (1998)

Rat-bite fever (RBF) is a systemic bacterial illness caused by Streptobacillus moniliformis that can be acquired through the bite or scratch of a rodent or the ingestion of food or water contaminated with rat feces. Cases are rarely reported in the United States and the true incidence of disease is unknown. On August 7, 1996, a physician in a rural community reported a case of infection with S. moniliformis bacteremia in a 15-year-old boy to the New Mexico Department of Health. This report summarizes the results of the investigation of this case and indicates the need for ongoing surveillance for this illness.
Pediatric Nephrology
Authors: Donald I. Moel
Journal: JAMA (1994)

The third edition of<i>Pediatric Nephrology</i>, edited by Holliday et al, is a textbook of pediatric nephrology appropriate for medical school libraries, pediatric department libraries, pediatric nephrology fellows, and pediatric nephrologists. It has almost 150 international contributors but remains satisfactorily consistent in style and organization with relatively little repetition. Like the second edition, the third, with 500 more pages, is contained in one volume. The binding of my second edition fell apart in two years; I hope that this will not happen to my copy of the third edition. This text is best compared with the second (1987) edition and with<i>Pediatric Kidney Disease</i>, edited by C. M. Edelmann, Jr (1992). As would be expected, the third edition of<i>Pediatric Nephrol ogy</i>is more current, but all three books cover extensively such subjects as evaluating patients, urinary tract disease, glomerular diseases, vascular and interstitial diseases, acute renal failure, chronic renal
In vitro evaluation of the mucolytic action of urea
Authors: J. Lieberman
Journal: JAMA (1967)

Urea has a mucolytic action on purulent or mucoid sputum when added in extremely large amounts (more than 0.2 gm urea per milliliter of sputum). No practical means for utilizing this action for aerosol therapy in lung disorders is foreseen since effective amounts of urea cannot be delivered into the lungs by any currently available method. The action of urea was shown to be irreversible and to be accompanied by the release of acid-soluble tyrosine in the sputum. Urea crystals may be useful for liquefying pus in decubitus ulcers or other sites of infection, or for liquefying sputum in preparation for bacteriologic studies.
Augmented oxidantive stress of platelets in chronic smokers Yoshinori Takajo, Hisao Ikeda, Nobuya Haramaki, Toyoaki Murohara, Takfumi Ueno, Atushi Katoh, Yoritaka Ohtuka, Tsutomu Imaizumi. the third dep og internal medicine, kurume, Japan
Journal: Journal of the American College of Cardiology (2001)