tbuckley/cabot-search huggingface dataset:
THE SURGICAL TREATMENT OF EXOPHTHALMIC GOITER.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sexual dysfunction and ocular timolol
Authors: I. M. Katz
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The letter from Dr F. T. Fraunfelder and S. Martha Meyer<sup>1</sup>states that the National Registry of Drug Induced Ocular Side Effects has received reports of 28 complaints of various sexual dysfunctions in 25 patients following usual doses of topical ocular timolol. Impotence was reported in 18 patients, decreased libido in nine patients, and decreased ejaculate volume in one patient. In a subsequent issue of<i>JAMA</i>, Curb et al<sup>2</sup>reviewed the results of the Hypertension Detection and Followup Program clinical trial in a cohort of 5,485 patients. According to the authors, this is the largest cohort to date from which detailed data on antihypertensive drug surveillance are available. Sexually related side effects of oral antihypertensive drugs are often a major concern, and in the Hypertension Detection and Follow-up Program study, discontinuation of oral antihypertensive drug treatment in 8.3% of the male patients resulted from these side
Second Week Postoperative Rash
Authors: Thomas J. Foley
Journal: JAMA (1972)

<h3>To the Editor.—</h3> New man-made diseases are the scourge of modern medicine. An example is "Third Day Surgical Fever."<sup>1</sup>This disease described by Altemeier, a great surgeon-bacteriologist, is caused by indwelling intravenous tubing. Now we have another—"The Second Week Postoperative Rash." This is a disease caused by long-term, massive, and broad-spectrum antibiotics, usually cephalosporins. It is characterized by intertriginous, oral, or vaginal rash usually associated with<i>Candida albicans</i>. The treatment is discontinuing the broad-spectrum antibiotic and changing to topical nystatin. The disease is not serious in the skin but should be a signal to be carefully watched. When discovered, great care should be exercised to prevent invasion of the bloodstream.<i>Candida albicans</i>in the axilla is a man-made nuisance;<i>C albicans</i>in the bloodstream is a preventable catastrophe.
The Care of the Child.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maternal and perinatal outcome in severe pregnancy-related liver disease.
Authors: S Pereira
Journal: Hepatology (1997)

Acute fatty liver of pregnancy (AFLP) and the syndrome of hemolysis, elevated liver enzyme levels, and low platelet count (HELLP) are rare but major disorders of the third trimester of pregnancy. Over a 10-year period, 46 women (median age, 30 years; range, 17-41 years) developed hepatic dysfunction severe enough to require transfer to our Liver Failure Unit. Three quarters of the women were nulliparous, and 5 had twin pregnancies; the median gestational age was 35 weeks (range, 24-40 weeks). At admission, 32 patients (70%) were preeclamptic and 21 (46%) were encephalopathic and/or ventilated. Thirty-two patients (70%) had clinical features and laboratory values consistent with AFLP, and 7 (15%) had HELLP syndrome. One patient had preeclamptic liver rupture requiring liver transplantation. In 6 other patients, causes of severe liver dysfunction unrelated to pregnancy were found. Infectious complications occurred in 17 of the patients with AFLP (53%) and in 2 of those with HELLP syndrome (29%). Major intra-abdominal bleeding occurred in 12 women (10 with AFLP), 9 of whom required laparotomies for clot evacuation. Four patients with AFLP (12.5%) had a fatal outcome, with a corresponding perinatal mortality rate of 9%. There were no maternal or perinatal deaths associated with HELLP syndrome. In contrast to results of many previous studies, the results of this large series suggest a relatively favorable maternal and perinatal outcome in severe AFLP and HELLP syndrome. Further improvements in outcome are likely to be achieved through the prevention of the bleeding and infectious complications associated with these disorders. (Hepatology 1997 Nov;26(5):1258-62)
Diagnostic and therapeutic technology assessment. BCG immunotherapy in bladder cancer: a reassessment
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Essential Thrombocythemia
Authors: Ayalew Tefferi, Animesh Pardanani
Journal: New England Journal of Medicine (2019)

Essential thrombocythemia is associated with increased risks of bleeding and thrombosis. Estimation of the risk of thrombosis is based on history of thrombosis, presence of the JAK2 V617F mutation, age, and cardiovascular risk. Treatment commonly involves low-dose aspirin; therapy is used in patients with high thrombotic risk.
Clinico-pathological relationship between androgen receptor (AR) and tumor infiltrating lymphocytes (TILs) in triple negative breast cancer (TNBC)
Authors: H. Elghazawy, M.O. Alorabi, T. Helal, A. Aref, M. Kelany, L.A. Eid Abdallah, F. Sayed, D. Ali, D. Zaki, M. Ahmed
Journal: Annals of Oncology (2019)

Background: Triple negative breast cancer (TNBC) is an aggressive subtype of with ill-defined therapeutic targets. Androgen receptor (AR) expression ranged from 32-53% in different reports presenting emerging biomarker in TNBC. Tumor-infiltrating lymphocytes (TIL) play an important prognostic and predictive value in TNBC. The relationship between AR, TIL and clinical behavior is still not fully understood. Methods: Thirty-six TNBC patients were retrospectively selected from a cohort of 800 patients diagnosed in 2012. Clinico-demographic data were collected. Formalin-fixed, paraffin embedded tissue specimens were evaluated for AR (+ ve if ≥ 1% expression), CD3, CD20, CD4, CD8 with IHC. Stromal TIL were quantified following the TIL Working Group recommendations. Lymphocyte-predominant breast cancer (LPBC) are defined as stromal TILs of ≥ 50%. Results: The mean age was 52.5 years and 27.8% were ≥60 years. The majority of patients (58.3%) were invasive duct carcinoma (IDC), while IDC with medullary features and invasive lobular carcinoma were 22% and 14% respectively. Grade III tumors were 52.8%. Stage III, IV were 54.3%, 8.6% respectively and N+ve were 77%. Seven patients of the total (19.4%) were AR+ve. TIL were assessed in 31 patients where LPBC was 32.3%. Median TIL was 15% and 33% (p = 0.07) and CD20 was 7% and 18% (p = 0.01) in AR+ve and AR-ve respectively. Mean CD3 was 93.3% and 80.6% (p = 0.007) and CD8 was 80.8% and 75% (p = 0.41) in AR+ve and AR-ve respectively. Majority of patients ≥60 years (66.7%) were lymphocyte deficient (TIL˂50%). CD8 was significantly lower in stage III/IV vs I/II (p = 0.04). LPBC type was significantly lower in N+ve vs N-ve patients (p = 0.03). Significant positive correlation presented between CD8 and CD3 (p˂0.001) while significant negative correlation presented between CD20 and CD3 (p = 0.03) and CD4 and CD8 (p = 0.04). Non statistically significant increased median OS in AR+ve vs AR-ve (44 vs 40 months, p = 0.84). Conclusions: The present study show that T cell marker (CD3) was more predominant in AR+ve TNBC. Older patients and N+ve were lymphocyte deficient (TIL˂50%). More studies are needed to focus on the clinical impact of the relation between AR and TIL in TNBC. Legal entity responsible for the study: Hagar Elghazawy. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
Advice zone
Authors: John Harrison, Kathy Ryan, Stephan Nikolas Larsson, Abhilash Jain, Emma Baker
Journal: BMJ (2004)

Got a career or university related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone at www.bmjcareers.com/advicezone to post a question or to see if one of our experts has already solved your problem
Guidelines of care for the management of primary cutaneous melanoma
Authors: Susan M. Swetter, Hensin Tsao, Christopher K. Bichakjian, Clara Curiel-Lewandrowski, David E. Elder, Jeffrey E. Gershenwald, Valerie Guild, Jane M. Grant-Kels, Allan C. Halpern, Timothy M. Johnson, Arthur J. Sober, John A. Thompson, Oliver J. Wisco, Samantha Wyatt, Shasa Hu, Toyin Lamina
Journal: Journal of the American Academy of Dermatology (2018)
Phosphorous 32 eye tumor identification test
Authors: J. H. Larose
Journal: JAMA (1976)

THE DIFFERENTIAL diagnosis of choroidal tumor masses presents a continuing challenge to the ophthalmologist. Two major types of neoplasms involve the uveal tract of the eye, namely primary malignant melanoma of the choroid and metastatic lesions from some primary site elsewhere in the body. However, a number of benign lesions, compatible with long life and good vision, can mimic potentially lethal choroidal tumors, and differentiating one from the other can be extremely difficult. Studies in the ophthalmologic literature<sup>1,2</sup>show that mistakes in diagnosis are frequently made, and that approximately one eye of every five enucleated with the diagnosis of malignancy of the choroid does not, in fact, contain a malignant lesion. On the other hand, some eyes that contain potentially lethal tumors are not removed, again because the diagnosis is either delayed or missed. Biopsy of lesions in the wall of the eye is not recommended because (1) biopsy
The reproducibility of submaximal work heart rates--supplementary note to the article published in BJSM Vol. 10, No. 2, June 1976.
Authors: K. Sykes, E. Pace, E. J. Charlesworth
Journal: British Journal of Sports Medicine (1977)

The previous article was based on two assumptions - (a) that the work heart rate (WHR)/work intensity slopes were the same for all subjects on all days; and (b) that any carry over of fatigue from the previous work bout would probably be small and would in any case be lumped into the residual error.This confounding of the carry-over effect of fatigue with the error term was one reason behind the selection of the Latin Cube design.
A picture is worth a thousand words
Authors: B. Davies
Journal: BMJ (2002)

Vitamin D stimulates transcription of anti-angiogenic and apoptotic factors that may suppress tumours, whilst vitamin D binding protein (DBP) may be a biomarker in murine lung cancer models. We sought to ascertain if the vitamin D axis is altered in lung cancer or influences prognosis. 148 lung cancer patients, 68 other intrathoracic cancer patients and 33 non-cancer controls were studied for up to 5 years. Circulating DBP and vitamin D levels were compared between groups and their effect on survival assessed by Cox regression analysis. Expression of DBP and vitamin D receptor (VDR) was examined in lung cancer cell lines and in normal and tumour lung tissue by Western blot and immunohistochemistry. Low serum DBP levels predicted lung cancer specific death (p=0.04), and DBP was poorly expressed in lung cancer cells on Western blot and immunohistochemistry. Vitamin D did not predict cancer survival, and VDR expression was variable in tumours. Preservation of serum DBP is a significant independent factor associated with better cancer outcome in operated lung cancer patients. Given the established role of DBP in macrophage activation and clearance of abnormal cells further study on its involvement in lung cancer is merited.
Search Begins for New NCI Director; Committee Named
Journal: JNCI Journal of the National Cancer Institute (1995)

Search Begins for New NCI Director; Committee Named Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 4, 15 February 1995, Pages 253–254, https://doi.org/10.1093/jnci/87.4.253 Published: 15 February 1995
Die Chirurgie der peripheren Nervenverletzungen mit besonderer Berücksichtigung der Kriegs-Nervenverletzungen.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Balloon dilation of the abdominal aorta
Authors: C. J. Tegtmeyer
Journal: JAMA (1980)

PERCUTANEOUS transluminal angioplasty was developed by Dotter and Judkins<sup>1</sup>in 1964 for the treatment of atherosclerotic peripheral vascular disease. Grüntzig and Hopff<sup>2</sup>revolutionized the technique when they developed the flexible balloon catheter. This versatility permitted successful dilation of the branches of the aorta, including the renal<sup>1</sup>and coronary<sup>4</sup>arteries. The present report describes the successful transluminal dilation of a lesion in the distal abdominal aorta. <h3>Report of a Case</h3> A 47-year-old woman was referred to the University of Virginia Medical Center with bilateral hip and lower extremity claudication. Over the past four months she had experienced progressive pain while walking. At the time of admission she described pain after walking a distance of only one block. Physical examination showed a bruit in the upper abdomen. Bruits were also heard over the iliac and femoral vessels bilaterally. The right femoral pulse was 2+, and the left femoral pulse
Factors Affecting the in Vitro Dissolution of Cobalt Oxide
Authors: Clare G. Collier, Marcia J. Pearce, Alan Hodgson, Adrian Ball
Journal: Environmental Health Perspectives (1992)

In a recent interspecies comparison of the lung clearance of cobalt oxide (57Co3O4), differences of up to 4-fold were found in the translocation rates of 57Co to blood between seven different animal species, including man. This study investigated some factors that could influence the dissolution of this material in vitro. The effect of bicarbonate and citrate concentrations (over physiological ranges) and medium pH on in vitro dissolution of 57Co from 57Co3O4 particles was measured in a simple noncellular system. pH levels of 4.5, 6.1, and 7.2 were used to correspond to those in the alveolar macrophage lysosome, its cytoplasm, and the extracellular lung fluid. Measurements of the fractional dissolution rate were made weekly for 3 months. pH had the greatest effect on dissolution rates, with particles suspended in the lowest pH medium (4.5) dissolving at a significantly faster rate than at higher pH values. Increasing citrate concentrations resulted in slightly higher dissolution rates, but there was no effect of bicarbonate concentration. There was no evidence of synergism between the factors studied.
Franklin and. Marshall College Obituary Record.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Forbidden Fruits
Authors: David H. Barnhouse
Journal: JAMA (1967)

<h3>To the Editor:—</h3> It appears that Dr. Bigg (<i>JAMA</i><b>199</b>: 343, 1967) has neglected to check his references. He falls subject to the common misconception that the forbidden fruit was an apple. This word is not mentioned at all either in Genesis or in any other biblical reference to the fall. The word used is "fruit." Before a correspondent refers to Jonah and the "whale," let me remind him that it was a "great fish" that the Lord prepared to save Jonah from the sea.
Risk-Adjusted Therapy of Acute Lymphoblastic Leukemia Can Decrease Treatment Burden and Improve Survival: Treatment Results of 2169 Unselected Pediatric and Adolescent Patients Enrolled in the Trial ALL-BFM 95.
Authors: Anja Möricke, Alfred Reiter, Martin Zimmermann, Helmut Gadner, Martin Stanulla, Wolf-Dieter Ludwig, Jochen Harbott, Georg Mann, Felix Niggli, Günter Henze, Karl Welte, Thomas Klingebiel, Charlotte Niemeyer, Felix Zintl, Hansjörg Riehm, Martin Schrappe
Journal: Blood (2007)
Demand pacing for transient heart block associated with changes in posture
Authors: V. D. Gaiha
Journal: JAMA (1971)

Complete heart block with syncope developed in an elderly woman upon standing. Sinus rhythm was reestablished upon lying down. Excessive vagal activity did not appear to be a causal factor, and an obvious explanation for the phenomenon is not available. Complete relief of symptoms was obtained by the use of a permanent demand transvenous pacemaker.
Production of chemotactic factor, interleukin-8, from hepatocytes exposed to ethanol
Authors: Y Shiratori
Journal: Hepatology (1993)

In a previous paper, we demonstrated proteinous chemotactic factors released from hepatocytes exposed to ethanol. In this study, we further characterized the chemotactic factors released from ethanoltreated hepatocytes. After fractionating the conditioned medium with gel chromatography, we demonstrated chemotactic activity at molecular weights of around 20 and 40 kD. When the conditioned medium was mixed with antiserum against interleukin-8, chemotactic activity was almost completely abolished. In addition, antiserum against interleukin-8 completely reduced chemotactic activity of the 20-kD chemotactic factor but did not influence the chemotactic activity of the 40-kD chemotactic factor. After gel electrophoresis of the conditioned medium, the protein reacted with antibody against interleukin-8 was demonstrated at a molecular weight of 20 kD but was not found at a molecular weight of 40 kD. These results suggest that a major part of the proteinous chemotactic factors released from hepatocytes exposed to ethanol could be a dimer form of interleukin-8, one of the proinflammatory cytokines, possibly contributing to the pathogenesis of alcoholic hepatitis. (HEPATOLOGY 1993;18:1477–1482.)