tbuckley/cabot-search huggingface dataset:
Mostly, a Number of Things
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Surgery
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1969)

Small IntestinePhysiology Regional absorption. Regional absorption has been discussed by Ingelfinger.77 Selective absorption occurs at various levels. Vitamin B12 and bile salts are absorbed primarily in the ileum. Calcium and iron absorption are maximal in the duodenum. The jejunum is prominent in the absorption of carbohydrates and proteins. Water and small solutes are also handled differently in various segments.The effect of distal ileac resection on gastric secretion has been studied by Reul and Ellison.78 Hypersecretion occurs with a marked proliferation of parietal cells; the hypersecretion can be blocked by atropine. Massive bowel resection. This operation . . .
WOOD ALCOHOL NOT FOR INTERNAL USE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19035: Cardiovascular QTc Interval-Prolonging Medications and the Risk of Death, Stroke and Incident Atrial Fibrillation in the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Khalid A Alburikan, Samuel T Savitz, James E Tisdale, Elsayed Z Soliman, Carla A Sueta, Sally C Stearns, Jo E Rodgers
Journal: Circulation (2015)

Objective: Prolongation of corrected QT interval (QTc) has been linked with increased risk of stroke, atrial fibrillation (AF) and mortality. We examined the associations between cardiovascular QTc prolonging medications (QTPMs) and these outcomes in a longitudinal study of a population-based cohort. Methods: We assessed 7,183 ARIC participants with a resting, standard 12-lead electrocardiogram and ≥ 1 measure of cardiovascular medication over up to four triennial examinations between 1987 and 1998. Participants with QRS ≥ 120 ms, atrial fibrillation and stroke were excluded. We identified participants using QTPMs classified as known, possible or conditional by CredibleMed®. Participants were followed on average for 3.2 visits, resulting in 18,287 person-visit observations for all users and 5, 178 for new users, no prior exposure). In all users and new users, we used generalized estimating equation logistic regression with inverse propensity score weighting to examine the association between cardiovascular QTPMs, in comparison to cardiovascular non-QTPMs, and the composite end point of death, stroke or incident AF within 3 years of each visit. The regressions controlled for person characteristics and whether QTPM were for cardiovascular conditions. Results: The participants’ mean age was 60 +4 years; 70% were females. The composite outcome occurred in 956 visits (5.2%) during the 3-year follow-up periods. Known cardiovascular QTPMs increased the risk of composite outcome threefold, due to significant increase for all components of the endpoint. In contrast, conditional cardiovascular QTPMs were associated with reduction in the composite end point.(Table). No participants were taking Possible QTPMs. Conclusions: Known cardiovascular QTPMs were associated with an increased risk of composite outcome of death, stroke and incident atrial fibrillation compared to cardiovascular non-QTPMs.
Missing Conflict of Interest Disclosure
Journal: JAMA Dermatology (2017)

Valentine Heidelberger, MD; Saskia Ingen-Housz-Oro, MD; Alicia Marquet, MD; Matthieu Mahevas, MD, PhD; Didier Bessis, MD, PhD; Laurence Bouillet, MD, PhD; Frédéric Caux, MD, PhD; Catherine Chapelon-Abric, MD; Sébastien Debarbieux, MD; Emmanuel Delaporte, MD; Anne-Bénédicte Duval-Modeste, MD; Olivier Fain, MD, PhD; Pascal Joly, MD, PhD; Sylvain Marchand-Adam, MD, PhD; Jean-Benoît Monfort, MD; Nicolas Noël, MD, PhD; Thierry Passeron, MD, PhD; Marc Ruivard, MD, PhD; Françoise Sarrot-Reynauld, MD; Denis Verrot, MD; Diane Bouvry, MD; Laurence Fardet, MD, PhD; Olivier Chosidow, MD, PhD; Pascal Sève, MD, PhD; Dominique Valeyre, MD, PhD
Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics
Authors: E. Stoffel, H. Maier, E. Riedl, M.-C. Brüggen, B. Reininger, M. Schaschinger, C. Bangert, E. Guenova, G. Stingl, P.M. Brunner
Journal: British Journal of Dermatology (2018)

TNF‐blockers have become a powerful and widely used treatment for many inflammatory diseases, including inflammatory bowel diseases and rheumatoid arthritis. While generally safe, one possible side effect consists of red, scaly patchy skin lesions that often look like psoriasis or eczema. These lesions can appear in up to one third of patients treated with TNF‐blockers over a time period of 10 years. The reasons why these skin lesions develop are still not completely understood. Researchers in Vienna and Zurich aimed to better characterize these lesions on several levels, including microscopic, cellular and molecular investigations. The researchers found that while most lesions indeed looked like eczema and psoriasis under the microscope, at a molecular level there were some characteristic differences from conventional psoriasis and eczema. In all of the lesions caused by TNF‐blockers, interferon gamma was present at high levels, a molecule that is a powerful inflammatory mediator produced by a specific set of immune cells. Results from this study might help to better guide future treatment approaches that can avoid such side effects.
Phase I–II Studies of Yttrium-Labeled Antiferritin Treatment for End-Stage Hodgkin's Disease, Including Radiation Therapy Oncology Group 87-01
Authors: H.M. Vriesendorp, J.M. Herpst, M.A. Germack, J.L. Klein, P.K. Leichner, D.M. Loudenslager, S.E. Order
Journal: Journal of Clinical Oncology (1991)

Figure 2 of the report "Phase I–II Studies of Yttrium-Labeled Antiferritin Treatment for End-Stage Hodgkin's Disease, Including Radiation Therapy Oncology Group 87-01" by Vriesendorp et al (J Clin Oncol 9:918–928) was presented incorrectly. It is shown here without error: Please see the PDF for Figure.
Polymers in Contact with the Body
Authors: Robert N. King, Donald J. Lyman
Journal: Environmental Health Perspectives (1975)

The clinical use of polymeric materials in the body to repair and restore damaged or diseased tissues and organs is substantially increasing on an annual basis. Concomitant with this use is an increase in materials related research on medically used polymers. Information on the historical and current clinical use of polymeric materials is provided in order to establish a basis for the philosophy and problems encountered in assessing the acceptability of various polymers in the biological system. The requisite properties which must be demonstrated by a polymer in contact with the body are discussed from two viewpoints, i.e., the effects of the material on the stability of the host and the effects of the host on the stability of the material. In addition, the effects of synthesis, processing, storage, sterilization, implantation, and possible degradation of polymers are discussed, poly(ethylene terephthalate) being used as an example.
Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly
Authors: S. L. Greenspan
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine the relative importance of fall characteristics, body habitus, and femoral bone mineral density (BMD) in predicting hip fracture in community-dwelling elderly. <h3>Design.</h3> —Prospective case-control study. <h3>Setting.</h3> —Community-based academic hospital. <h3>Participants.</h3> —A total of 149 ambulatory, community-dwelling fallers (126 women, 23 men) aged 65 years and older, including 72 case patients (fallers with hip fracture) and 77 control fallers (fallers with no hip fracture). <h3>Main Outcome Measures.</h3> —Fall characteristics, body habitus, femoral BMD. <h3>Results.</h3> —Significant and independent risk factors for hip fracture in both sexes were direction of the fall (adjusted odds ratio [OR], 5.7; 95% confidence interval [Cl], 2.3 to 14.0;<i>P</i>&lt;.001); femoral neck BMD (a decrease of 1 SD; adjusted OR, 2.7; 95% Cl, 1.6 to 4.6;<i>P</i>&lt;.001); potential energy of the fall (an increase of 1 SD; adjusted OR, 2.8; 95% CI, 1.5 to 5.2;<i>P</i>&lt;.001); and body mass index (a decrease of 1 SD; adjusted OR, 2.2; 95% Cl, 1.2 to 3.8;<i>P</i>&lt;.01). Importantly, the OR for the fall direction was unaffected by the addition or removal of BMD from the model. <h3>Conclusions.</h3> —We conclude that among elderly fallers—in most of whom hip BMD is already less than the fracture threshold—fall characteristics and body habitus are important risk factors for hip fracture and touch on a domain entirely missed by knowledge of BMD. These data suggest new targets for preventive therapy. In addition to the maintenance of bone density, reductions in fall severity (eg, by use of trochanteric padding or enhancement of muscle strength) may provide additional strategies for prevention of hip fracture in this age group. (<i>JAMA</i>. 1994;271:128-133)
Intracranial Aneurysms
Authors: Wouter I. Schievink
Journal: New England Journal of Medicine (1997)

Intracranial aneurysms are acquired lesions that are most commonly located at the branching points of the major arteries coursing through the subarachnoid space at the base of the brain (Figure 1). A subarachnoid hemorrhage due to the rupture of an intracranial aneurysm is a devastating event associated with high rates of morbidity and mortality. Approximately 12 percent of patients die before receiving medical attention,1 40 percent of hospitalized patients die within one month after the event,26 and more than one third of those who survive have major neurologic deficits.26 Furthermore, persistent cognitive deficits are present in many patients . . .
Onzieme Congres de Chirurgie
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Results of a Comparison of Serologic Tests Used to Detect Human Antibodies to a Herpesvirus (HLV) Associated With Burkitt's Lymphoma2
Journal: JNCI Journal of the National Cancer Institute (1969)

A total of 133 serums from Burldtt's lymphoma patients, leukemia patients, and age-, sex-, and geographic-matched controls for each of the two groups was surveyed by 7 serologic methods for reactivity with the herpes-like virus (HLV) present in cultured Burkitt's lymphoma cells. Tests were performed in the laboratories of the individuals who first applied particular serologic methods for this purpose, as well as in one contract laboratory. The results showed that 4 tests—indirect immunofluorescence, complement fixation, coating reaction, and Ouchterlony (immunodiffusion)—are positive only when HLV is present and consistently negative when HLV is absent. Positive results in the other 3 tests—cytotoxicity, mixed hemadsorption, and indirect membrane immunofluorescence—showed no relationship to the presence of virus or the state of malignancy from which the cells were derived. The 3 virus-specific, quantitative tests—indirect immunofluorescence, complement fixation, and antibody coating—showed higher antibody titers in the serum of Burkitt's lymphoma patients than in control serums.
Psoriasis
Authors: S. Wright
Journal: Annals of the Rheumatic Diseases (1986)

Tissue typing in brucellosisSIR, We read with interest the article by Dawes and Ghosh on tissue typing in brucellosis.'The lack of association between reactive arthritis due to acute B abortus infection and HLA antigens, reported by them, confirms our observations in patients infected by B melitensis.2In order to define the genetics of this condition we have recently performed HLA typing in families with two or more Correspondence, Book reviews 351 members affected by brucellosis3 and in patients with brucellar spondylitis.4None of these studies showed linkage between brucellosis caused by B melitensis, with or without arthritis, and the HLA system.The increased frequency of A2 in brucellosis patients, observed by Dawes and Ghosh', and of B27 in brucellar spondylitis, reported by Hodinka et al,5 are in contrast with our findings but might be explained by the different antigenic structures of B abortus and B melitensis' and/or the genetic background of the populations studied.
Linitis Plastica or Diffusely Infiltrating Type of Carcinoma of the Colon
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polycyclic Aromatic Hydrocarbons (PAHs), Nitro-PAHs and Related Environmental Compounds: Biological Markers of Exposure and Effects
Authors: Glenn Talaska, Patricia Underwood, Andrew Maier, Joellen Lewtas, Nathaniel Rothman, Marlene Jaeger
Journal: Environmental Health Perspectives (1996)

Lung cancer caused by polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and related environmental agents is a major problem in industrialized nations.The high case-fatality rate of the disease, even with the best supportive treatment, underscores the importance of primary lung cancer prevention.Development of biomarkers of exposure and effects to PAHs and related compounds is now underway and includes measurement of urinary metabolites of specific PAHs as well as detection of protein and DNA adducts as indicators of effective dose.Validation of these markers in terms of total environmental dose requires that concurrent measures of air levels and potential dermal exposure be made.In addition, the interrelationships between PAH biomarkers must be determined, particularly when levels of the marker in surrogate molecules (e.g., protein) or markers from surrogate tissues (e.g., lymphocyte DNA) are used to assess the risk to the target organ, the lung.Two approaches to biomarker studies will be reviewed in this article: the progress made using blood lymphocytes as surrogates for lung tissues and the progress made developing noninvasive markers of carcinogen-DNA adduct levels in lung-derived cells available in bronchial-alveolar lavage and in sputum.Data are presented from studies in which exfoliated urothelial cells were used as a surrogate tissue to assess exposure to human urinary bladder carcinogens in occupational groups.
Cryptococcal pleural effusion
Authors: J. D. Smilack
Journal: JAMA (1975)

IN RECENT years, infection by<i>Cryptococcus neoformans</i>has received increased attention. Although infection with this agent commonly occurs in the compromised host, approximately 50% of cases occur in healthy individuals.<sup>1</sup> The most commonly recognized form of cryptococcal disease is chronic meningitis. While the respiratory tract is the usual portal of entry of the organism, relatively few reports of pulmonary cryptococcal disease have appeared in the literature, and cases of primary pulmonary infection are recognized infrequently. Pleural infection appears to be recognized even less commonly. We describe a patient with widespread Hodgkin disease who developed fatal disseminated infection with<i>C neoformans</i>manifested by meningitis and predominant pleuropulmonary involvement. <h3>Report of a Case</h3> In July 1971, a 21-year-old man was seen with cervical adenopathy. Biopsy showed Hodgkin disease of mixed cellularity type, and it was subsequently classified as stage IA. He received radiotherapy to the right side of the neck. In
Guidelines for Essential Trace Element Preparations for Parenteral Use
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Attenuation of Oxidant-Induced Lung Injury by 21-Aminosteroids (Lazaroids): Correlation with the mRNA Expression for E-Selectin, P-Selectin, ICAM-1, and VCAM-1
Authors: Robert L. Griffin, Raymond F. Krzesicki, Stephen F. Fidler, Craig L. Rosenbloom, John A. Auchampach, Anthony M. Manning, Joseph V. Haas, Sue K. Cammarata, Jia En Chin, Ivan M. Richards
Journal: Environmental Health Perspectives (1994)

We compared the effects of treatment with methylprednisolone or the 21-aminosteroids, U-74389 and U-74006F (Tirilizad mesylate), on hyperoxic lung injury and the associated expression of mRNA for several adhesion molecules in rats.Inhalation of >95% oxygen for up to 72 hr in Sprague-Dawley rats produced a marked increase in lung weight and an accumulation of fluid in the thorax when compared with air-breathing con- trols.Hyperoxia also induced a marked neutrophil-rich influx of inflammatory cells into the bronchial lumen as measured by bronchoalveolar lavage.Neutrophil numbers in bronchoalveolar lavage fluid peaked after 60 hr of exposure to > 95% oxygen; this was associated with a marked upregula- tion of mRNA for the adhesion molecules P-selectin and E-selectin but not VCAM-1.mRNA for ICAM-1 was constitutively expressed at high levels in both air-breathing controls and in the lungs of rats exposed to high concentrations of oxygen.Pretreatment with the 21-aminosteroids reduced hyperoxic lung damage and improved survival times in animals exposed to >95% oxygen.However, treatment with methylprednisolone significantly decreased survival times.Treatment with U-74389 did not significantly (p > 0.05) inhibit the BAL neutrophilia and did not significantly (p > 0.05) reduce hyperoxia-induced increases in mRNA expression for P-selectin and E-selectin.The inhibition of hyperoxic lung damage coupled with improved survival seen in treated animals suggests that 21-aminosteroids may provide valuable treatments for pulmonary disorders in which oxidant damage has been implicated.
The prevalence of multi-resistant bacterial infections in patients with decompensated cirrhosis admitted to the intensive care unit
Authors: Fischer Petra, Pandrea Stanca Lucia, Ralica Hateganu, Adina Hadade, Simona Margarit, Horia Stefanescu, Marcel Tantau, Daniela Ionescu, Bogdan Procopet
Journal: Journal of Hepatology (2020)