tbuckley/cabot-search huggingface dataset:
Abstract 1506: Upregulation of Cardiac AT <sub>1</sub> Receptor Signaling Inhibits Myocyte Contractile Performance, [Ca <sup>2+</sup> ] <sub>i</sub> Transient, and Ca <sup>2+</sup> Current in Alcoholic Dogs: Insights into the Underlying Molecular Mechanism
Authors: Heng-Jie Cheng, Carol C Cunningham, Zhu Shan Zhang, Zakariya K Shihabi, David C Sane, Thomas Wannenburg, Satoshi Masutani, William C Little, Che-Ping Cheng
Journal: Circulation (2007)

Background. Chronic alcohol ingestion is accompanied by sustained renin-angiotensin system (RAS) activation followed by progressive left ventricular (LV) myocyte dysfunction. This suggests a role for angiotensin II (AII) in the development of alcoholic cardiomyopathy (ACM). We tested the hypothesis that chronic alcohol intake may cause upregulation of AII AT 1 receptors and altered cardiac inotropic response to AII stimulation, thus contributing to the development of ACM. Methods. We compared LV myocyte AT 1 - and AT 2 -receptor mRNA and protein levels, myocyte contractile function, [Ca 2+ ] i transients ([Ca 2+ ] iT ), and Ca 2+ current (I Ca,L ) in response to AII (10 −6 M) in 16 instrumented dogs over 6 months. Eight animals received alcohol (once per day orally, providing 33% of total daily caloric intake), and eight were controls. Myocytes were isolated from LV myocardial biopsy tissues. Results . Compared with controls, the alcoholic myocytes showed increased AT 1 mRNA (0.69 vs 0.33) and protein levels (0.79 vs 0.37) ( p &lt;0.01). Conversely, AT 2 mRNA (0.18 vs 0.16) and protein concentration (0.16 vs 0.14) were relatively unchanged. Importantly, in alcoholic myocytes, the increased AT 1 receptors were associated with altered myocyte inotropic response to AII. In control myocytes, superfusion of AII (10 −6 M) increased myocyte systolic amplitude (SA, 14.9 vs 12.4%) and the maximum rate of shortening (dL/dt max , 203.1 vs 153.9 μm/s) accompanied by significant increases in [Ca 2+ ] iT (1.52 vs 1.21) and I Ca,L (4.0 vs 3.3 pA/pF). In alcoholic myocytes, this positive response was reversed. AII caused significant decreases in SA (3.4 vs 5.8 %), dL/dt max (50.5 vs 78.9 μm/s), and the maximum rate of relaxation (dR/dt max, 37.5 vs 59.6 μm/s) associated with reduced [Ca 2+ ] iT (0.86 vs 1.12) and I Ca,L (1.5 vs 2.1 pA/pF) ( p &lt;0.05). These AII-induced changes in alcoholic myocytes were abolished by incubation of alcoholic myocytes with an AT 1 receptor blocker, losartan (10 −5 M), or pretreatment with a G i inhibitor, PTX (2 μg/ml, 36°C, 5h). Conclusions. In a canine model, chronic alcohol consumption produces upregulation of LV myocyte AII AT 1 receptors and alters myocyte functional response to AII stimulation, which may promote the development of ACM.
Book Review Artificial Pneumothorax in Pulmonary Tuberculosis: Including its relationship to the broader aspects of collapse therapy. By T. N. Rafferty, M.D. With an introduction by Henry S. Willis, M.D. 8°, cloth, 192 pp., with 26 illustrations and 14 tables. New York: Grune and Stratton, 1944. $4.00.
Journal: New England Journal of Medicine (1945)
Auditorium Maximus
Authors: Abraham Verghese
Journal: Annals of Internal Medicine (1990)

Ad Libitum15 January 1990Auditorium MaximusAbraham Verghese, MDAbraham Verghese, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-2-152_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI slept in Auditorium MaximusAs you spoke,My eyelids tiring in pursuitOf the Bouncing Laser Light-your heavy batonMesmerizing, but then, with the drone of your voThe dreamy stairs sloped away, dimly lit,Even the potted fernBelow the Non-Fumare sign,Looked to the ground.Please no more gels,Itinerant purines, probable antigens,Putative adhesins-scoundrels the lot of them,Unwelcome behind sunset eyelids.Lines of identify deceive, driftingIn shades of Coomassie blue.Your fame preceded you to the podiumReigning in unblinking galleriesSilent with your preamble,Attentive, even, until the first obscure dropsClouded our... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Johnson City, Tennessee PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1990Volume 112, Issue 2Page: 152-152KeywordsAntigensPurines ePublished: 1 December 2008 Issue Published: 15 January 1990 Copyright & Permissions©1990 American College of PhysiciansPDF downloadLoading ...
SEPTIC FEVER AND TYPHOID INFECTION.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of surgery in the management of lymphoma
Authors: J. B. Allison
Journal: JAMA (1981)

WITHIN the field of cancer treatment, the most gratifying advances have probably been made in the lymphoma group, especially those of the Hodgkin's type; over the past two decades predicted survival rates have increased dramatically. Newer concepts and understanding of the Hodgkin's group of lymphomas have generated a cautiously optimistic attitude that Hodgkin's disease is eminently curable. Although the hematologistoncologist and radiotherapist bear the brunt of the management, the surgeon can contribute in a meaningful and positive way in both nodal and extranodal disease of all histological types. With this in mind, the classification, staging, and treatment of the lymphomas will be reviewed briefly, as will the role of surgery in the diagnosis, therapy, staging, and post-treatment restaging. <h3>PATHOLOGICAL CLASSIFICATION AND STAGING</h3> The diagnostic feature of Hodgkin's disease is the multinucleated Reed-Sternberg giant cell, with subtyping based on the ratio of other cell types (Table 1). With the exception of
Secondary prevention programmes in coronary heart disease improve care
Journal: BMJ (2001)

Secondary prevention programmes in coronary heart disease improve care Specialised multidisciplinary clinics for patients with coronary heart disease improve patient care and quality of life or functional status.McAlister and colleagues reviewed 12 randomised controlled trials including nearly 10 000 patients and found greater prescription of efficacious drugs and better risk factor profiles in patients assigned to specialised clinics rather than usual care (p 957).Admissions to hospital were also reduced.The optimal mix of components and the cost effectiveness of the clinics remain unclear.
Antiemetic Efficacy of Fluphenazine with Comparative Results of Inventory and Biometrical Evaluation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Varicella Outbreak Among Vaccinated Children—Nebraska, 2004
Journal: JAMA (2006)

On November 19, 2004, a school nurse notified the Nebraska Health and Human Services System (NHHSS) of a varicella outbreak in an elementary school (grades kindergarten through 7). In collaboration with local health department officials and CDC, NHHSS initiated a retrospective cohort study to determine the magnitude of the outbreak, assess vaccine coverage and effectiveness, and compare disease severity among vaccinated and unvaccinated students. This report summarizes the investigation and considers the suitability of school settings for case-based surveillance. The findings highlighted the importance of improving varicella vaccination coverage and implementing varicella vaccination school-entry requirements.
Error in Figure Labels
Authors: Torrey Schmidt, Ronald Maag, Andrew Foy
Journal: JAMA Internal Medicine (2017)

the oculostenotic reflex is strong as evidenced by the patient in our Teachable Moment, 3 and the incentive structure in the US system promotes overuse. 4,5 Other harms from overdiagnosis may include fear and anxiety related to being labeled with CAD, as well as risks associated with medication changes targeted at primary prevention.While overdiagnosis carries risks, the possibility of benefit exists as well.The meta-analysis 2 cited by Singh et al found that CCTA lowered the risk of myocardial infarction by 42%.The absolute reduction is small (0.3%) and corresponds to a number of patients needed to scan of 333 to prevent 1 myocardial infarction. 2 Conversely, only 36 patients need to be scanned to lead to an excess revascularization procedure. 2All-cause death was unchanged between groups.Singh et al believe that CCTA improves patient care by promoting the use of aspirin, statins, and healthy lifestyle changes.Whether this actually improves clinical outcomes is uncertain.The FACTOR 64 trial 6 randomized patients with diabetes to screening with CCTA or standard care; CCTA identified incidental CAD in 69% of patients and led to a change in management in more than two-thirds, but there was no improvement in patient outcomes.The trial 6 has been criticized for being underpowered but, to our knowledge, is the best randomized data available at present.We do agree with Singh et al that in an era of increasingly sensitive diagnostic tests, the importance of teaching critical thinking skills cannot be overemphasized.But we also think it is important to recognize the tradeoffs that are associated with increased disease detection, most importantly, overdiagnosis and its consequences.
The organic food myth
Authors: T. H. Jukes
Journal: JAMA (1974)

MANY people are worried about contamination that they think exists in their foods. This feeling has always existed, and it is now focused on a fear of "chemical residues" and "additives." The apprehension resulted in part from a series of widely publicized episodes; among them are the banning of cyclamates, contamination of poultry meat with polychlorinated biphenyls (PCBs) and dieldrin, the "Chinese Restaurant syndrome" (attributed to monosodium glutamate), nitrates in baby foods, and the bans on diethylstilbestrol (DES) in meat, and on the use of DDT in agriculture. Some of these incidents are the results of highly sensitive analytical methods used for detecting minute traces of contaminants. Indeed, contaminants are readily found, but at levels not known to have any injurious effect. The fear of residues in foods is actually based on a state of mind, not on tangible evidence. Progress in technology has placed us consumers out of touch
Gurrent Medical Literature.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Illustrations of the Working of the Contagious Diseases Act
Authors: B. Hill
Journal: BMJ (1868)

THE Contagious Diseases Act is enforced only in the first of these three places; but the others, particularly Winchester, are in frequent com- munication with Aldershot; and I have grouped them together that the necessity of the Act in the localities wvhere no preventive measures are enforced may be placed in strongcr relief.Alders/tot.-Previously to the Act being put in force here, the condition of the women there equalled in wretchedness that of the " Wrens of the Curragh", so vividly described in the PU AflMall Gazette last October.Last spring, scores of women lay out under the hedges and in ditches around Aldershot, in a frightfully diseased condition; their only other refuge being the celebrated Farnham Union.They lived on the small sums they got from the soldiers, who associated with them notwithstanding their foul and dangerous state.This, of course, has been greatly improved; but since the Act has been in force, even so late as last August, a girl was found by the police living in a drain.She had been there three weeks, being carried thither by her companions and abandoned when dea(l drunk and penniless.Having no other home, she had remained there, receiving men hard by.When found by the police, she was literally swarming with vermin, to hide which she kept her thin gown dramw tightly over her head.At the time of my visit to
THE HUMAN FACTOR IN MOTOR VEHICLE ACCIDENTS: PHYSICAL OR MENTAL DISABILITIES
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
mRNA deadenylation and telomere disease
Authors: Philip J. Mason, Monica Bessler
Journal: Journal of Clinical Investigation (2015)

An investigation by the University Health Network recently found that portions of the RT-PCR gels shown in Figure 1, B (PGK-1 panel) and C (FGFR1 panel), are duplicated in this publication and in a subsequent publication (1).The samples were labeled differently in the panels, and the marker was shifted in Figure 1B.The corresponding author has indicated that other data from the initial screen of these samples support the conclusions made in the paper; however, the original data for the RT-PCR gels shown in Figure 1 are no longer available.The JCI's policies prohibit data manipulation and data duplication.Therefore, the JCI is retracting this article.No issues have been raised in regard to any of the other data in this manuscript.
Treatment Stage Migration Maximizes Survival Outcomes in Patients with Hepatocellular Carcinoma Treated with Sorafenib: An Observational Study
Authors: Clarence Yen, Rohini Sharma, Lorenza Rimassa, Tadaaki Arizumi, Dominik Bettinger, Huay Yee Choo, Tiziana Pressiani, Michela E. Burlone, Mario Pirisi, Laura Giordano, Anisa Abdulrahman, Masatoshi Kudo, Robert Thimme, Joong Won Park, David James Pinato
Journal: Liver Cancer (2017)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Level I evidence supports the use of sorafenib in patients with Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma, where heterogeneity in efficacy exists due to varying clinicopathologic features of the disease. &lt;b&gt;&lt;i&gt;Aim:&lt;/i&gt;&lt;/b&gt; We evaluated whether prior treatment with curative or locoregional therapies influences sorafenib-specific survival. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; From a prospective data set of 785 consecutive patients from international specialist centres, 264 patients (34%) were treatment naïve (TN) and 521 (66%) were pre-treated (PT), most frequently with transarterial chemoembolization (&lt;i&gt;n&lt;/i&gt; = 413; 79%). The primary endpoint was overall survival (OS) from sorafenib initiation with prognostic factors tested on uni- and multivariate analyses. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Median OS for the entire cohort was 9 months; the median sorafenib duration was 2.8 months, with discontinuation being secondary to progression (&lt;i&gt;n&lt;/i&gt; = 454; 58%) or toxicity (&lt;i&gt;n&lt;/i&gt; = 149; 19%). PT patients had significantly longer OS than TN patients (10.5 vs. 6.6 months; &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Compared to TN patients, PT patients had a better Child-Pugh (CP) class (CP A: 57 vs. 47%; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and a lower BCLC stage (BCLC A-B, 40 vs. 30%; &lt;i&gt;p&lt;/i&gt; = 0.007). PT status preserved an independent prognostic role (&lt;i&gt;p&lt;/i&gt; = 0.002) following adjustment for BCLC stage, α-fetoprotein, CP class, aetiology, and post-sorafenib treatment status. PT patients were more likely to receive further anticancer treatment after sorafenib (31 vs. 9%; &lt;i&gt;p&lt;/i&gt; &lt; 0.001). &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Patients receiving sorafenib after having failed curative or locoregional therapies survive longer and are more likely to receive further treatment after sorafenib. This suggests an incremental benefit to OS from sequential exposure to multiple lines of therapy, justifying treatment stage migration in eligible patients.
Correction.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastroenterology
Authors: Sumner C. Kraft
Journal: JAMA (1964)

This second edition of Volume II of a three-volume set is well organized and has been thoroughly rewritten by Dr. Bockus and 36 of his present and former colleagues. It encompasses diseases and conditions of the small intestine, colon, peritoneum, mesentery, and omentum, The authors have included pertinent discussions of anatomy, pathology, and physiology, in addition to emphasizing a sound clinical approach to intestinal problems. They have made extensive use of photomicrographs and roentgenograms and have done an admirable job of correlating causative factors, clinical features, diagnostic aids, differential diagnosis, and therapy. As one might expect in a work of this magnitude, there may not be universal agreement with the views of every contributor. For example, many would take exception with the statement (p 182) that in the Peutz-Jeghers syndrome "radical resection is justified because of the danger of malignant change." In general, however, controversial issues have been covered in
Ultrastructure and metabolism of the nervous system. Research Publications, Association for Research in Nervous and Mental Disease. Vol XL. Proceedings of the Association, Dec 9-10, 1960, N.Y.
Journal: JAMA (1963)

This current volume of the always admirable<i>Proceedings</i>presents 24 studies on finer morphological and chemical aspects of the nervous system. Electronmicroscopy, membrane structure and function, amino acids and protein metabolism, enzymes, endocrine relationships are a few of the topics covered in this excellent presentation. The publication maintains the usual high standards. The illustrations are superb.