tbuckley/cabot-search huggingface dataset:
Interactions of Dietary Estrogens with Human Estrogen Receptors and the Effect on Estrogen Receptor-Estrogen Response Element Complex Formation
Authors: Georgi N. Nikov, Nancy E. Hopkins, Stephen Boue, William L. Alworth
Journal: Environmental Health Perspectives (2000)

Epidemiologic and experimental studies support the hypothesis that dietary estrogens from plant sources (phytoestrogens) may play a role in the prevention of breast and prostate cancer. The molecular mechanisms for such chemopreventive effect are still unclear. We investigated the possibility that phytoestrogens may bind differentially to estrogen receptor proteins (ER[alpha] and ERss) and affect the interactions of the ligand-ER complexes with different estrogen response element (ERE) sequences. We used fluorescence polarization to measure the binding affinities of genistein, coumestrol, daidzein, glyceollin, and zearalenone for human ER[alpha] and ERss. Competition binding experiments revealed higher affinity of the phytoestrogens for ERss than for ER[alpha]. Genistein [median inhibitory concentration 12nM] is the most potent and has the same relative binding affinity for ERss as 17ss-estradiol. We also studied the effect of these phytoestrogens on the ability of ER[alpha] and ERss to associate with specific DNA sequences (EREs). The direct binding of human recombinant estrogen receptors to fluorescein-labeled EREs indicates that phytoestrogens can cause conformational changes in both human ERs, which results in altered affinities of the complexes for the ERE from the Xenopus vitellogenin A2 gene and an ERE from the human pS2 gene.
Real-world clinical practice outcomes in hepatitis C-infected patients with psychiatric and substance use disorders treated with glecaprevir/pibrentasvir for 8 or 12 weeks: a pooled analysis across nine countries
Authors: Pietro Lampertico, Robert Flisiak, Nuno Marques, Olivier Clerc, Ioannis Goulis, Mark Bondin, Ariel Porcalla, Zhenzhen Zhang, Yves Horsmans, Harald Hofer, Ella Veitsman, Georges-Philippe Pageaux
Journal: Journal of Hepatology (2020)
Alcohol-related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study
Authors: Gyongyi Szabo, Patrick S. Kamath, Vijay H. Shah, Mark Thursz, Philippe Mathurin
Journal: Hepatology (2018)

A joint meeting of the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) was held in London on September 30 and October 1, 2017. The goals of the meeting were to identify areas of broad agreement and disagreement, develop consensus, and determine future directions to ultimately reduce the burden, morbidity, and mortality of alcohol-related liver disease (previously termed alcoholic liver disease). The specific aims of the meeting were to identify unmet needs and areas for future investigation, in order to reduce alcohol consumption, develop markers for diagnosis and prognosis of disease, and create a framework to test novel pharmacological agents with pre-specified treatment endpoints. A table summary of these goals and aims is provided in the context of epidemiology, current management strategies, next steps for future trials and translational science.
Wood's Medical and Surgical Monographs. Vol. II, No. 1.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bioequivalence of Levothyroxine Preparations: Industry Sponsorship and Academic Freedom-Reply
Authors: Joseph B. Martin
Journal: JAMA (1997)

<h3>In Reply.</h3> —As industry funding for university research increases in quantity and complexity, it seems inevitable that there will be occasional clashes of culture. The case involving Dr Dong and colleagues is one such unfortunate chapter in the annals of university-industry relations, annals that are otherwise filled with tales of highly innovative and productive collaborations that have delivered enormous benefit to the public and built for our nation a research and development capability that is unmatched among the nations of the world. We must view incidents such as that involving Dong and colleagues as only temporary setbacks and learn from them how we can make our relationships more harmonious and mutually productive. Even the smallest lessons we all continue to learn are too important to ignore. Let me make one comment in response to Mr Eckert's letter. He states, "As a partner in research, we have a responsibility to ensure that work
Abstract LB-090: Molecular and pharmacological characterization of mutant NRAS dependency in melanoma cell lines
Authors: Anita K. Mehta, Kevin Hua, Jayant Gadrey, Angelina Fuller, Anurag Singh
Journal: Cancer Research (2019)

Abstract Oncogenic NRAS mutations are found in 20 percent of sporadic melanoma cases. Mutant NRAS activates the RAF/MEK/ERK mitogen-activated protein kinase (MAPK), PI3K/AKT and RAC1/PAK kinase signaling pathways, which cooperate to drive melanomagenesis. The complexity of the NRAS signaling network presents a challenge to develop effective therapeutics for NRAS mutant melanoma. Many inhibitors of NRAS-regulated signaling pathways, such as BRAF and MEK/ERK inhibitors are ineffective in this setting. Furthermore, direct NRAS inhibition is pharmacologically challenging. It is likely that combined inhibition of two or more nodes in the NRAS signaling network will be effective in treating NRASmutant melanoma. We have used whole-genome transcriptional profiling coupled with phenotypic characterization of NRAS dependency to derive an NRAS dependency gene expression signature. The signature reveals two key features: (1) NRAS dependency is associated with an kinase-regulated inflammatory gene expression program and (2) expression of the melanocyte lineage factor MITF is strongly associated with NRAS-independent cell proliferation. Based on this knowledge, we have identified combinatorial therapeutic modalities to target either NRAS-dependent or NRAS-independent melanoma subtypes. NRAS-dependent melanoma cell lines undergo apoptotic cell death upon combined inhibition of PAK kinases and Bcl2/Bcl-XL proteins. Conversely, NRAS-independent cell lines are sensitive to the apoptotic effects of combined CDK2 and ERK kinase inhibition. Notably, CDK2 is an MITF transcriptional target gene that mediates a feed-forward loop to potentiate MITF activation. Taken together, our studies highlight phenotypic variations in NRAS mutant melanomas that can be exploited to identify subtype-specific therapeutic targets for NRAS mutant melanoma. Citation Format: Anita K. Mehta, Kevin Hua, Jayant Gadrey, Angelina Fuller, Anurag Singh. Molecular and pharmacological characterization of mutant NRAS dependency in melanoma cell lines [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-090.
Decrease Set, Decease Meant
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of mathematics in cancer research: attitudes and training of Japanese mathematicians
Authors: A Kudô
Journal: Environmental Health Perspectives (1979)

An extensive survey of attitude towards scientific information of scientists in Japan was conducted in Japan.It was published in a technical report, and this survey is reviewed in this paper, with the hope that this will furnish findings important in working out the plan for promoting exploitation of mathematical talent in biomedical research.Findings are concordant with the impression of foreign visitors: (1) pure mathematicians tend to concentrate on mathematics only; (2) applied mathematics and statistics are heavily oriented toward industry; (3) mathematicians and pharmacologists are very different in their attitudes to scientific information.Based on the personal experience of the author, difficulties to be circumvented in utilizing aptitudes for mathematics and/or statistics in biomedical research are discussed.
Sinus node dysfunction caused by methyldopa and digoxin
Authors: J. C. Davis
Journal: JAMA (1981)

Symptomatic sinus bradycardia developed in two patients while they were taking methyldopa and digoxin. In one patient, bradycardia did not occur with either digoxin or methyldopa alone. The other patient, who had never taken methyldopa alone, did not demonstrate bradycardia with digoxin alone. In each patient, normal sinus node function was demonstrated after methyldopa and digoxin therapy was discontinued. Both patients continued to receive digoxin without recurrence of bradycardia. (<i>JAMA</i>1981;245:1241-1243)
LEUKANEMIA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Influence of Hybridization Upon the Natural Resistance of Mice to the Progressive Growth of Sarcoma 37
Journal: JNCI Journal of the National Cancer Institute (1941)

The Influence of Hybridization Upon the Natural Resistance of Mice to the Progressive Growth of Sarcoma 37 H. B. Andervont H. B. Andervont principal biologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 1, August 1941, Pages 1–6, https://doi.org/10.1093/jnci/2.1.1 Published: 01 August 1941
Sex "Deviation"
Authors: Mary S. Calderone
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In expressing appreciation of the enlightened and enlightening paper of Marmor (<b>217</b>:165, 1971), I would like to add a comment to the first paragraph of his comment, in which he states The fact that we now refer to sexual "deviations" rather than to "perversions" already represents an evolutionary change within our culture toward a moral objective and scientific approach to these problems, in contrast to the highly moralistic and perjorative approach of the previous generation. Perhaps some day we shall talk simply of "variations" in sexual object choice. I would like to urge that, in the interests of true scientific objectivity, we replace the term "deviant behavior" as soon as possible with the term "variant behavior." In public lectures, in which for several years I have been trying to reach the public in nontechnical terminology with the objective understandings so well stated by Marmor, I have
Testimonial to Dr. Berncastle
Authors: C. W. Steel
Journal: BMJ (1848)

now for many years tried electricity, and proved its powerful remedial agency in various diseases, I can most conscientiously advise its use in any future unfortunate case of anaesthesia that may occur, as well as in the asphyxia that follows an overdose of prussic acid, and also in narcotism following the abuse of opium, or any other vegetable poison.In either case, so confident am I of its power and efficacy, that I should feel myself very uncomfortable had I not a machine, and an efficient one, at hand, to fly to immediately in case of an un- toward accident.
Missing Signature Block and Author Affiliations for In Reply Letter
Authors: Kristin Corapi, Julia Wenger, Ishir Bhan
Journal: JAMA Internal Medicine (2015)

associated with loop diuretic use and that the rise in serum PTH level was a compensatory response to maintain serum calcium within the normal range.This relationship has been seen in specific patient populations, including those with chronic kidney disease 2 or congestive heart failure. 3Thus, in selecting covariates we included both estimated glomerular filtration rate and a history of congestive heart failure in our final model.Loop diuretics are occasionally used in the treatment of other conditions, such as resistant hypertension.Some patients with resistant hypertension who are prescribed loop diuretics may have a component of chronic kidney disease, which may also influence the relationship with PTH. 4 To address the suggestion by García de Tena et al, we revisited the National Health and Nutrition Examination Survey (NHANES) data set: a questionnaire item captured a history of high blood pressure, and the examination portion of NHANES included up to 3 blood pressure measurements (in our cohort, 75% of patients had 3 blood pressure measurements).We added both assessments of hypertension to our previously published model, defining measured hypertension as a mean blood pressure higher than 140/90 mm Hg.Regardless of which definition was applied (questionnaire-based definition or measured blood pressure), loop diuretic use remained a significant predictor of PTH (β = 0.11 [P = .001]and β = 0.12 [P < .001],respectively).We thank García de Tena and colleagues for their thoughtful suggestion.There may well be confounding between loop use and a diagnosis of hypertension; however, this did not extinguish the significant relationship between loop diuretic use and PTH level.
Somatic Antigen Vaccine in Impetigo of Indians
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RELATION OF CALCIUM AND BILIRUBINEMIA TO INTOXICATION WITH CARBON TETRACHLORIDE
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe acute respiratory syndrome: patients were epidemiologically linked
Journal: BMJ (2003)

depressant. 18Under normal circumstances, the interpenetration of industry and academe can be fruitful, as talent and ideas wash back and forth.Yet when drugs start earning the kind of money usually associated with the oil industry, there is potential for trouble. ConclusionsWe believe that the failure to advance the treatment of anxiety and depression is related to wrong classification.If you don't have natural disease categories, you can't develop drugs for them.If the Food and Drug Administration will accept only drugs that are effective for DSM diagnoses, and if the diagnoses are artefacts, the drugs are bound to be less valuable, even if in the short term they increase their market share.Companies must start developing drugs for mixed anxiety and depression and forget about dividing this giant illness segment into salami slices.Doctors could encourage this change by being more cynical about pitches from drug representatives claiming to have "the latest" in anxiolytic medication.Ask instead for the latest in nervousness. 19 Contributors and sources: ES has carried out research on historical aspects of psychiatry over many years, wherever possible studying documents that are key to the making of decisions by policy makers and psychiatric bodies.Most recently, he has worked in the archives of the US Food And Drug Administration and the American Psychiatric Association.PT has carried out clinical trials into the drug and psychological treatment of anxiety and depression since 1969 and has been involved in field trials for the 10th revision of the International Classification of Diseases (ICD-10).Competing interests: PT has received support from the Mental Health Foundation to evaluate the outcome of anxiety and depressive disorders.
SAT0032 Pro-Resolving Mediators Issued from Apoptotic Cell Efferocytosis (SuperMApo) Modulate APC Properties toward A Tolerogenic Profile: Efficacy in The Treatment of Collagen- Induced Arthritis
Authors: F. Bonnefoy, R. Vallion, M. Couturier, A. Daoui, E. Toussirot, S. Perruche
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Pro-resolving mediators produced by macrophages eliminating apoptotic effector cells during the resolution of inflammation have been shown to stop inflammation, favor tissue repair and return to homeostasis. In immune-mediated inflammatory diseases such as rheumatoid arthritis (RA), one may believe that reintroducing pro- resolving mediators would allow the control of the disease. We have developed a cell culture system of macrophages and apoptotic cells that mimics this phase of resolution. The supernatant of this cell culture system called SuperMApo (SUPERnatant issued from Macrophage APOptotic cell culture) is enriched in pro-resolving factors including anti- inflammatory cytokines like TGF-b. <h3>Objectives</h3> to evaluate the effects of SuperMApo in the treatment of collagen-induced arthritis (CIA). <h3>Methods</h3> SuperMApo is obtained after 48h of culturing macrophages from peritoneal cavity with apoptotic cells obtained from thymus after X-ray irradiation. CIA was used as a model of RA. SuperMApo (200 μL of 5x concentrated SuperMApo, IV, for 2 days) was injected in score 8 CIA mice. The effect of SuperMApo was first evaluated on APC and T cells from naive mice in terms of phenotype, profile and properties such as maturation of APC before or after TLR-ligand stimulation and T cell polarization assays. Then, SuperMApo was evaluated in vivo in CIA mice. <h3>Results</h3> Macrophages, cDC and pDC submitted to SuperMApo demonstrated robust insensitivity to TLR ligand-induced activation, particularly in terms of co-stimulatory molecules expression. Spleen cells cultured with SuperMApo demonstrated a strong Treg increase. This was confirmed using naive CD4+CD25– T cells cultured in the presence of SuperMApo showing Foxp3 expression. CIA mice received 2 injections of SuperMApo (over 48h) and demonstrated a significant long term decrease of CIA (joint score before and after SuperMApo: 8–10 and 1–4, respectively; sustained response to 60 days). This clinical improvement was associated with a higher suppressive function of Treg. Treg transfer from mice treated by SuperMApo to arthritic mice induced joint improvement. Finally, we tested SuperMApo effect on PBMC issued from 4 patients with RA, with and without TLR ligand activation. Our results were that monocytes from 3 patients showed a decreased inflammatory phenotype after overnight exposure to SuperMApo (CD80, CD86, CD40 and HLA-DR expression). <h3>Conclusions</h3> these data demonstrated that macrophages eliminating apoptotic cells produced pro-resolving mediators affecting APC properties therefore allowing the control of arthritis in the CIA model. <h3>Disclosure of Interest</h3> None declared