tbuckley/cabot-search huggingface dataset:
Anesthesia History
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies on Rubella in Pregnancy: Report of the Public Health Laboratory Service Working Party on Rubella
Journal: BMJ (1968)

In a further survey of women of child-bearing age neutralizing antibody to rubella virus was found in 80 to 96% of those sampled from different parts of the country.When assessment was restricted to susceptible pregnant contacts and rubella in the index case was confirmed by virus isolation immunoglobulin in the dosage used did not appear to give any appreciable protection.One instance of a confirmed second attack after known exposure to rubella among more than 100 immune contacts is recorded.The implications of all these findings are discussed.
Gene Scene: Studies Begin to Yield Clues About Disease Progression After HIV Infection
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5033: The role of the epigenetic regulator SATB2 in colon cancer progression
Authors: Donal J. Brennan, Kirsha Naicker, Sudipto Das, Bruce Moran, Rut Klinger, Fredrik Ponten, Stephen Hewitt, Karin Jirström, Annette T. Byrne, Jacintha O'Sullivan, William M. Gallagher, Darran P. O'Connor
Journal: Cancer Research (2019)

Abstract SATB2 is a nuclear matrix-associated transcription factor that orchestrates gene expression by regulating higher-order chromatin structure. Using antibody-based screening of 48 normal human tissues and 20 cancer types, we identified SATB2 as a protein almost exclusively expressed in gastrointestinal tissue. We confirmed this observation at the mRNA level in 10,533 human tissue samples. Differential expression of SATB2 was observed in colorectal cancer, with loss of expression occurring along the adenoma-carcinoma sequence. Additionally, SATB2 expression was markedly decreased in metastatic SW620 colon cancer cells and siRNA knockdown of SATB2 expression in parental SW480 cells increased their growth and migratory capacity. Ectopic expression of SATB2 in the metastatic variant reversed the observed phenotype. Using tissue microarray and automated image analysis of SATB2 expression in colorectal cancers (n=309), SATB2 was demonstrated by multivariate Cox regression analysis to be an independent predictor of disease-specific survival (HR=0.52, 95% CI 0.32-0.83, p=0.006). SATB2 mRNA levels were examined in a second cohort (n=290) and again, SATB2 was demonstrated to be an independent predictor of disease-specific survival (HR=0.40, 95% CI 0.18-0.92, p=0.031). Interestingly, in colorectal cancer patients, SATB2 levels significantly correlated with CD3+ T-cell infiltrates in the tumours (p=0.006) and inversely correlated with COX2 expression (p=0.019). In two independent colorectal cancer cohorts (n=467), SATB2-low tumours were found to be significantly enriched in the CMS1 (immune-related) subtype (p&amp;lt;0.001). Gene set enrichment analysis revealed that SATB2 low tumours demonstrated altered immune signalling with significant increases in IFNγ (p=0.001), IL6 (p=0.001), IL8 (p&amp;lt;0.001) TFGβ (p&amp;lt;0.001), which was mirrored by in vitro manipulation of SATB2 expression in colon cancer cells. Furthermore, in a longitudinal cohort of patients with ulcerative colitis, we observed a significant correlation between loss of SATB2 expression and occurrence of future cancers (p=0.013). We therefore postulate that SATB2 acts as a master regulator of the inflammatory response in the gut and loss of expression is significantly associated with the progression of colorectal cancer. Citation Format: Donal J. Brennan, Kirsha Naicker, Sudipto Das, Bruce Moran, Rut Klinger, Fredrik Ponten, Stephen Hewitt, Karin Jirström, Annette T. Byrne, Jacintha O'Sullivan, William M. Gallagher, Darran P. O'Connor. The role of the epigenetic regulator SATB2 in colon cancer progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5033.
The Status of Indoor Air Pollution
Authors: Nurtan A. Esmen
Journal: Environmental Health Perspectives (1985)

Indoor air pollution, specifically restricted in its meaning to chemicals in home indoor air environment, presents a new and probably an important challenge to the researchers of the air pollution field. The general overview of this topic suggests that the voluminous data generated in the past ten or so years have only defined the rudiments of the problem, and significant areas of research still exist. Among the important areas where information is lacking, the exposures to contaminants generated by the use of consumer products and through hobbies and crafts represent perhaps the most urgent need for substantial research.
Cancer of the urogenital tract: prostatic cancer. Introduction
Authors: P. Rubin
Journal: JAMA (1969)

Prostatic carcinoma offers a different challenge to members of different disciplines, since it is not one disease entity but many, by virtue of its varied initial symptoms and evolution (Introductory Figure). Most clinicians think that prostate cancer consists of good and evil varieties. At the favorable end of the spectrum is the microinvasive cancer or carcinoma in situ, discovered incidentally in an incipient or occult stage, or the distinct, circumscribed, small nodule detected on routine examination. On the ominous side of the spectrum is the metastatic disease which appears as a case of arthritis, sciatica, or chronic back pain with minimal or no urinarytract complaints. An illusion exists among many physicians that this is not a lethal cancer and that much can be done to alter its course at any stage in its progression. Although the evolution of cancer of the prostate is not as rapid as that of the
STRICTURE OF THE ŒSOPHAGUS.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress in Reducing Measles Mortality—Worldwide, 1999-2003
Journal: JAMA (2005)

Measles remains an important cause of childhood mortality, especially in developing countries. In the joint Strategic Plan for Measles Mortality Reduction, 2001-2005, the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) targeted 45 priority countries with high measles burden for implementation of a comprehensive strategy for accelerated and sustained measles mortality reduction. Components of this strategy include achieving high routine vaccination coverage (>/=90%) in every district and ensuring that all children receive a second opportunity for measles immunization. In May 2003, the World Health Assembly endorsed a resolution urging member countries to reduce deaths attributed to measles by half (compared with 1999 estimates) by the end of 2005. This report updates progress toward this goal and summarizes recent recommendations on methods to estimate global measles mortality.
PARESIS AND PSEUDO=PARESIS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ALCOHOL MANIFESTO.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immune Reconstitution
Authors: Irving L. Weissman, Judith A. Shizuru
Journal: New England Journal of Medicine (1999)

In this issue of the Journal, Markert et al.1 teach us that transplanting pieces of human thymus can rescue children with the DiGeorge syndrome. Complete DiGeorge syndrome is a rare congenital disorder in which the thymus and parathyroids fail to develop; the result is long-lasting T-cell deficiency. It is a medical and scientific triumph that transplantations of fetal or postneonatal thymus fragments can lead to T-cell neogenesis, the achievement of T-cell immune competence, and, for some patients, the ability to live at home in an otherwise hostile microbial environment.Although the disease is rare, it represents a unique opportunity to . . .
Carcinogenesis Studies in Rodents for Evaluating Risks Associated with Chemical Carcinogens in Aquatic Food Animals
Authors: James Huff, John Bucher, Raymond Yang
Journal: Environmental Health Perspectives (1991)

FIsh and selish caught in polluted waters contain poentially dangerous amounts ofti an carcinogenic l Public concern was heightened when a large percentage ofwinter founder taken from Boston Harbor wa found to have visiblecancer ofthe Diver; winterflounderoutsidetheesuary ara had no livwerlesons.LIng-tenn cbemicalcardnogenesis sudies could be esily and feasibly designd using laboratory rodentsoffred diet _contaling fshcaught in pollted waters.Induced cancers in rodents would corroborate field observations in fish; positive results from these studies would pro- vide futhe evienc about potenti human health hazards from eaing s l amounts of emlly ontaminated fish.Nonetheless, fish and aquatic orgnisms should be viewed as environmental biological monitors of polution or of potential human heth harwds, and authoritis responsible for asuring clan and safe rivers, bodies ofwater, and biota should give more attention to these valid biological indicators or sentinels ofenvhinmental polution.Consequendy, fish and other sea creatures alone should serve as alarms regarding whether water areas constitute public health hazards.
Cost-effectiveness of HMG-CoA reductase inhibition for primary and secondary prevention of coronary heart disease
Authors: L. Goldman
Journal: JAMA (1991)

To determine the cost-effectiveness of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors (such as lovastatin) for the primary and secondary prevention of coronary heart disease, we used the Coronary Heart Disease Policy Model, a computer-simulated model that estimates the risk factor-specific annual incidence of coronary heart disease and the risk of recurrent coronary events in persons with prevalent coronary heart disease. When used for secondary prevention, 20 mg/d of lovastatin was estimated to save lives and save costs in younger men with cholesterol levels above 250 mg/dL (6.47 mmol/L) and to have a favorable cost-effectiveness ratio regardless of the cholesterol level except in young women with cholesterol levels below 250 mg/dL (6.47 mmol/L). Doses of 40 mg/d of lovastatin had favorable incremental cost-effectiveness ratios in men with cholesterol levels above 250 mg/dL (6.47 mmol/L). By comparison, primary prevention had favorable cost-effectiveness ratios only in selected subgroups based on cholesterol levels and other established risk factors. We conclude that current national recommendations regarding medication for secondary prevention are not as aggressive as our projections would suggest, while recommendations regarding the use of medications for primary prevention should consider the cost of medication as well as the risk factor profile of the individual patient. (<i>JAMA</i>. 1991;265:1145-1151)
Error in Abstract
Authors: Robert Tufts, Keerthi Gogineni, Katherine Shuman, Nicole Gabler, Ezekiel Emanuel
Journal: JAMA Oncology (2015)

Andrew E. Teschendorff, PhD; Zhen Yang, PhD; Andrew Wong, PhD; Christodoulos P. Pipinikas, PhD; Yinming Jiao, MSc; Allison Jones, BSc; Shahzia Anjum, PhD; Rebecca Hardy, PhD; Helga B. Salvesen, MD; Christina Thirlwell, PhD; Samuel M. Janes, PhD; Diana Kuh, PhD; Martin Widschwendter, MD
Idiopathic hypoventilation
Authors: J. L. Grant
Journal: JAMA (1965)

Thin as well as fat people may chronically underbreathe and, though their lungs are normal, the resulting hypoxia may lead to pulmonary hypertension and even to cor pulmonale. Cardiac therapy may then allow a level of breathing which partly corrects hypoxia and hypercapnia, thus breaking the vicious cycle which contributed to the heart failure initially. One cannot treat the lesion in the medullary respiratory center, but treatment of heart failure, artificial ventilation, and oxygen may, as in the present case, permit the patient to return to work. Prevention of heart failure then allows a level of breathing which partly corrects anoxia and hypercapnia and, in turn, prevents recurrent episodes of heart failure.
Hazardous Solid Waste from Domestic Wastewater Treatment Plants
Authors: William M. Harrington
Journal: Environmental Health Perspectives (1978)

The treatment of liquid wastes in municipal sewage treatment plants creates significant quantities of solid residue for disposal. The potential hazard from these wastes requires that their characteristics be determined accurately to develop environmentally sound management criteria. It is readily recognized that the sludge characteristics vary with the type and degree of industrial activity within a wastewater collection system and that these characteristics play a significant role in determining whether the material has potential for beneficial reuse or if it must be directed to final disposal. This paper offers an overview of past and present practices of sewage sludge disposal, an indication of quantities produced, and experience with beneficial reuse. An estimated range of costs involved, expected environmental effects and potential for continued use is offered for each disposal or reuse system discussed.
The emergency medical care system
Authors: R. F. Manegold
Journal: JAMA (1967)

Medicine's lifesaving techniques and the system organized to deliver them are in sharp contrast. Progress in medicine's lifesaving techniques is dramatic. Today there are cardiac monitors and pacemakers, exquisite surgical techniques, drugs of great potency, institutions splendidly equipped and superbly staffed. These are available for many. Emergency medical systems in most cities and nearly all rural areas, however, do not often enough bring the patient at the right time to the right place; nor is there assurance the patient will get the proper treatment by the proper professional. Progress in this system is not dramatic. An emergency need exists in a patient's mind until he is convinced by a health professional that his life or well-being or that of a loved one is not threatened. When an emergency exists, professional decisions are required to determine the time, the type, the amount and the place of treatment. The child with a
LETTER FROM EUROPE.Major Girard, Surgeon U. S. Army, to Professor Senn.
Authors: A. C. Girard
Journal: JAMA (1894)

No. V. <h3>THE INTERNATIONAL MEDICAL CONGRESS AT ROME.</h3> Rome, Italy, April 7, 1894. <h3>Dear Dr. Senn:</h3> —When I promised you a letter from Rome, relating to the International Medical Congress, I did not realize the import of the promise. I had been at the International Congress at Copenhagen and found there no difficulty in following the work of one or two Sections; at least, made notes as the papers were read, and elaborated them at night, so that at the end of the Congress I had a fairly full report of the general sessions and of at least one Section ready for the press. I found matters quite different here, and have been obliged to postpone this letter to the end of the Congress in order to arrange my notes and collect material, when I could not be present in person. I find that my account of this Congress can
Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell–derived lin–CD34+CD43+CD45+ progenitors
Authors: Kyung-Dal Choi, Maxim A. Vodyanik, Igor I. Slukvin
Journal: Journal of Clinical Investigation (2009)

Basic research into human mature myelomonocytic cell function, myeloid lineage diversification and leukemic transformation, and assessment of myelotoxicity in preclinical drug development requires a constant supply of donor blood or bone marrow samples and laborious purification of mature myeloid cells or progenitors, which are present in very small quantities. To overcome these limitations, we have developed a protocol for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, DCs, and Langerhans cells from human embryonic stem cells (hESCs). As a first step, we generated lin–CD34+CD43+CD45+ hematopoietic cells highly enriched in myeloid progenitors through coculture of hESCs with OP9 feeder cells. After expansion in the presence of GM-CSF, these cells were directly differentiated with specific cytokine combinations toward mature cells of particular types. Morphologic, phenotypic, molecular, and functional analyses revealed that hESC-derived myelomonocytic cells were comparable to their corresponding somatic counterparts. In addition, we demonstrated that a similar protocol could be used to generate myelomonocytic cells from induced pluripotent stem cells (iPSCs). This technology offers an opportunity to generate large numbers of patient-specific myelomonocytic cells for in vitro studies of human disease mechanisms as well as for drug screening.
Army center helps severely burned patients push survival 'envelope'
Authors: T. Randall
Journal: JAMA (1991)

PATIENTS who initially survive devastating burns that cover 80% or more of their bodies undergo profound and prolonged physiological changes. Just 10 years ago, very few of these patients survived. Today, about half of them will. A burn unit likely to care for these severely burned patients is the US Army Institute for Surgical Research (USAISR), at Fort Sam Houston, San Antonio, Tex. The USAISR is the world's largest institute dedicated to burn research and, since 1949, it has led or participated in nearly every major development in the treatment of burns. About 250 burned patients, from both civilian and military populations, are treated there a year. The typical patient has partial- and full-thickness burns that cover 40% of the body surface area. "The burn patient is really a universal trauma model," says Basil A. Pruitt, MD, the US Army colonel who is commander of the institute. "All the changes