tbuckley/cabot-search huggingface dataset:
Factors Affecting Workload of Cancer Clinical Trials: Results of a Multicenter Study of the National Cancer Institute of Canada Clinical Trials Group
Authors: Kathyrn Roche, Nancy Paul, Bobbi Smuck, Marlo Whitehead, Benny Zee, Joseph Pater, Mary-Anne Hiatt, Hugh Walker
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Increasingly, cancer treatment centers need to be able to estimate specific costs and resources associated with clinical trials. Because the time requirements of trial coordination and data collection are not well known, the Clinical Research Associates (CRA) Committee of the National Cancer Institute of Canada Clinical Trials Group carried out a multicenter study to measure trials’ task times and evaluate the effects of certain factors. METHODS: A data collection instrument was designed and validated before its implementation in the study. Eighty-three CRAs from 24 cancer treatment institutions across Canada collected timing observations of 41 tasks (156 subtasks). Information from all stages of trials activity (protocol management, eligibility and entry, treatment, and follow-up and final stage) was obtained, from initial negotiations to follow-up after study closure. RESULTS: After controlling for stage, phase and sponsor were found to be significant independent factors. Analysis within the stages showed similar patterns. New drug inclusion as a factor was confounded with phase. Industry-sponsored studies had significantly higher overall mean times than did local and cooperative group studies. Early-phase studies required more time than did phase III trials. External sponsorship of any kind increased CRA time more than that necessary for locally coordinated studies, except during the protocol management stage. The burden of a phase I study increased to greater than average once underway and accruing patients. CONCLUSION: Our data demonstrated that sponsor and study phase are important factors to be taken into consideration when estimating clinical trial costs and resource use.
Author Index
Authors: Patricia L. Dobkin, Robert O. Pihl, Claude Breault, M.J. Christie, D. French, L. Weatherstone, A. West, M. Rigatelli, M. Marcon, A.R. Morritti, R. Rizzardo, S. Novarin, G. Forza, M. Cosentino, Hideki Teshima, Hiroshi Sogawa, Koji Mizobe, Naoko Kuroki, Tetsuya Nakagawa, Brian Baker, Paul Dorian, Nadia Woloshyn, Shahe Kazarian, Caroline Lanphier, Julian Hafner, Robyn J. Miller, Michèle Montreuil, Roland Jouvent, Solange Carton, Catherine Bungener, Daniel Widlöcher, Jussi Kauhanen, Juhani Julkunen, Jukka T. Salonen
Journal: Psychotherapy and Psychosomatics (1991)
War HospitalWar Hospital
Authors: Michael VanRooyen
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is a Matched Unrelated Donor Search Needed for All Allogeneic Transplant Candidates?
Authors: Stefan O. Ciurea, Maria Cecilia Borges Bittencourt, Denái R. Milton, Kai Cao, Piyanuch Kongtim, Gabriela Rondon, Julianne Chen, Marina Y. Konopleva, Jorge M. Ramos Perez, Mohammed Elshazly, Majdi Aljadayeh, Michele Alvarez, Jin S Im, Gheath Alatrash, Rohtesh S. Mehta, Uday Popat, Qaiser Bashir, Betul Oran, Chitra Hosing, Issa F. Khouri, Partow Kebriaei, Richard E Champlin
Journal: Blood (2018)
Mining and abandoned vein
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Information Technology and Patient Care: Who, When, and Why?
Authors: Pepi Granat
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The conclusion of Dr Rootenberg's<sup>1</sup>article that "the future of health care provision rests with practice guidelines and outcomes analyses in managed care settings" is debatable. Clinical input cannot be truly measured; use of technology to manage information is not what clinical thought and action are about. Should it come to pass, we are all at great peril. Medicine by algorithm will slide backward, become robotic, devoid of creativity, humanity, commitment, and perspicacity. Clinicians, acting and reacting daily in the trenches, depend on keeping up with new knowledge. Print material is fast and transportable and conferences offer collegiality. Computer updates can lag behind print material. Many items do not make it to the supposedly comprehensive databases. In the academic center, tertiary specialists peer down narrow tunnels looking for the light of integrated medical reality while doing heroic work. They treat many inner-city patients, where outcomes may
ELEVATION OF CONJUNCTIVA NEAR LIMBUS PREVIOUS TO CATARACT EXTRACTION
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
APLASTIC ANEMIA AND RELATED CONDITIONS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantitative Microdetermination of Enzymes in Sweat Gland
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessment of circulating tumor cell (CTC) patterns among disease-free breast cancer patients vaccinated with adjuvant HER2/neu-based peptide vaccines.
Authors: K. S. Clive, T. A. Summers, G. T. Clifton, R. Patil, J. Tyler, J. P. Holmes, E. A. Mittendorf, A. Stojadinovic, S. Ponniah, G. E. Peoples
Journal: Journal of Clinical Oncology (2010)

2542 Background: The initial CTC count, and the reduction in CTC post-treatment predict outcome in metastatic and local breast cancer (BCa) patients. However, the CTC response in treated disease-free BCa patients following administration of a preventive vaccine is unknown. We have assessed CTC in clinically disease-free BCa patients to determine the incidence of CTC in a cohort of vaccinated patients, the correlation with known prognostic factors, and the response to vaccination with immunogenic HER2/neu peptides. Methods: The CellSearch System (Veridex, LLC Warren, NJ) was used to enumerate the total CTC in blood samples (20 ml) obtained from patients (n=81) enrolled in the E75 or GP2/AE37 phase II vaccine trials. Prognostic factors and CTC response to vaccine were monitored. Results: Of the 81 patients, 47 (58%) had CTC detectable (CTC+) prior to vaccination, with mean and median number of CTC being 3 and 2, respectively. Compared to patients without CTC (CTC-; n=34), the CTC+ patients were younger (median age 50 vs. 57; p=0.026) and more likely to have node-positive (NP) disease (70% vs. 35%; p=0.003). Other prognostic factors evaluated (≥T2, grade 3, ER-/PR-, and HER2/neu+ disease) demonstrated no correlation with CTC. In addition, CTC decreased post-vaccination in both trials, with a decline in 63% of CTC+ patients in the E75 trial, and 66% of CTC+ patients in the GP2/AE37 trial. There was an overall decline in mean CTC from 2.6 to 0.6 (p=0.007) post-vaccination. Evaluation of pre-/post-booster CTC in E75 patients receiving booster vaccine (n=19) demonstrated a decrease 62% of the time, with a decline in mean CTC from 1.4 to 0.6 (p=0.001). Conclusions: CTCs are readily detectable in disease-free BCa patients and correlate with young age and NP disease. CTCs decline during the course of vaccination and following administration of boosters. These findings suggest a role for monitoring CTC in the response to adjuvant vaccine-based immunotherapy. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Antigen Express, Veridex
Correction: Error in Table
Journal: Annals of Internal Medicine (2000)

Corrections1 February 2000Correction: Error in TableFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-3-200002010-00024 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In an article on a rapid whole-blood assay for d-dimer in the diagnosis of pulmonary embolism (1), Table 2 contains two errors. The likelihood ratio and 95% CI for patients with a negative result on d-dimer testing and a normal lung scan should be 0.33 (95% CI, 0.06 to 1.78). The 95% CI for the likelihood ratio in patients with a positive result on d-dimer testing and a high-probability lung scan should be 1.1 to 2.6.Reference1. Ginsberg JS, Wells PS, Kearon C, Anderson D, Crowther M, Weitz JI, et al . Sensitivity and specificity of a rapid whole-blood assay for d-dimer in the diagnosis of pulmonary embolism. Ann Intern Med. 1998;129:1006-11. LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 2000Volume 132, Issue 3Page: 247KeywordsD-dimerLikelihood ratioLungsPulmonary embolism ePublished: 15 August 2000 Issue Published: 1 February 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Correction
Journal: Journal of Clinical Investigation (1997)

Column two, first paragraph.) Assuming for blood a viscosity of 4 centipoise, the numerical value of shear stress (in dyn/cm 2 ) corresponds to shear rate divided by 40.The previous sentence should have read:Assuming for blood a viscosity of 4 centipoise, the numerical value of shear stress (in dyn/cm 2 ) corresponds to shear rate divided by 25.
Evaluation of Chronic Uremia
Authors: Joel D. Kopple
Journal: JAMA (1974)

In chronically uremic men receiving carefully controlled diets of varying protein intake during metabolic study, the ratio of serum urea nitrogen (SUN) to serum creatinine correlated closely with protein intake. This ratio was altered abruptly by even minor catabolic stresses or dehydration. The ratio of SUN to creatinine can be used to estimate the daily protein intake and can indicate the presence of unrecognized catabolic stress. Knowledge of its relation to protein intake can be used to determine the degree of protein restriction required to achieve a certain SUN level. In subjects undergoing periodic hemodialysis, SUN-serum creatinine ratios were lower, and the SUN level was a better indicator of dietary protein intake than the SUN-creatinine ratio.
Popular Beliefs and Scientific Facts
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply:
Authors: Stephen Freedland
Journal: Journal of Clinical Oncology (2005)

our initial hypothesis, an elevated BMI predicts for longer overall survival.One obvious hypothesis for this observation is that men with the most advanced cancer have cachexia, resulting in weight loss and possibly height loss, and a "normal BMI." Patients with less advanced cancer continue to have a normal appetite and maintain their basal (and often elevated) BMI.Regardless of the explanation, our findings confirm an impact of obesity on the behavior of human prostate cancer.Investigating the mechanism(s) by which obesity affects the growth of human cancer seems to be a fruitful area of research.
Abstract 18663: Myocardial Heterogeneity in Heart With Postinfarction LV Remodeling and its Response to Cell Therapy
Authors: weina cui, lei ye, albert jang, qiang xiong, pengyuan zhang, jianyi zhang
Journal: Circulation (2015)

Rationale and Objective: Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury. Here, we investigated the functional impact and myocardial heterogeneity of bioenergetics using a porcine model of post infarction LV remodeling, and 2 dimensional chemical shift imaging (2D CSI) P-31 MR spectroscopy. Methods and Results: Ischemia-reperfusion (I/R) injury was surgically induced by occlusion distal LAD (OCCL) for 60 minutes in female Yorkshire farm swine (≈15kg), then randomly assigned to experimental groups: 1) 16 million human induced pluripotent stem cells (hiPSC) derived cardio myocytes (CMs), smooth muscle cells (SMC) and Endothelia cells (ECs) were directly myocardial injected through an epicardial fibrin patch (P+Cell, n= 4), 2) open patch (fibrin patch with no cell) were placed over the injury site (P w/o Cell, n=4). Size matched normal (n=9) and OCCL only (n=5) pigs were also studied. Four weeks after I/R, 2D CSI MRS studies were performed in a 9.4T/ 65 cm bore magnet. In vivo myocardial energetic mapping was achieved using 31 P 2D CSI. To measure the forward flux rate PCr to ATP, 2D CSI data were acquired with or without saturation on ATPγ resonance. I/R injury has a heterogeneous effect on LV myocardial bioenergetics. Myocardial creatine phosphate (PCr)/ATP ratio is significantly decreased in border zone (BZ) of the infarction than the myocardial areas remote from the scar (RZ) in cell treated and patch only groups (1.54+/- 0.05 vs 2.25 +/- 0.10, 1.49+/-0.07 vs 2.34 +/- 0.07, BZ vs RZ, p&lt;0.05). The BZ PCr/ATP ratio is improved in the cell treated group compared with open patch group (1.71 +/- 0.05 vs. 1.54 +/- 0.05, p&lt;0.05). The forward flux rate constant of PCr/ATP (k pcr→ATP ) in the border zone is slightly increased in cell treated group compared with patch only group (0.29 +/- 0.02 vs 0.22 +/- 0.04 , p&lt;0.05) Conclusion: The approach of 2D CSI 31 P MRS can effectively map the heterogeneity of myocardial ATP flux rate via CK In Vivo porcine hearts. Postinfarction LV remodeling heart manifests pronounced heterogeneity in myocardial bioenergetics with most severe alterations in BZ. Cell therapy may effectively improve BZ myocardial bioenergetics.
neuroendocrine tumors and CUP
Authors: Sara De Dosso, Emilio Bajetta, Giuseppe Procopio, Laura Catena, Antonia Martinetti, Marco Platania, Elena Verzoni, Andrea Colombo, Nadia Birocco, Marco Volante, Virginia Caliendo, Mario Macripo, Alfredo Berruti, Luigi Dogliotti, Patrizia Lista, Michela Donadio, Mauro Papotti, Libero Ciuffreda
Journal: Annals of Oncology (2006)
Acute esophageal variceal sclerotherapy. Results of a prospective randomized controlled trial
Authors: A. W. Larson
Journal: JAMA (1986)

Within 48 hours of variceal hemorrhage, 82 patients were randomly assigned to conventional treatment including balloon tamponade or to conventional treatment supplemented by sclerotherapy. The prerandomization general clinical characteristics of the two groups were similar. Seventy-nine percent of patients were alcoholic and 57% were in Child's class C. In the sclerotherapy group of 44 patients, sclerotherapy was performed twice in 28 patients and thrice in 13 patients over the two weeks of follow-up. The number of patients who rebled was significantly lower in the sclerotherapy group than in the group treated conventionally (23% vs 53%). The number of bleeding episodes also was significantly lower in the sclerotherapy group (15 vs 32). Moreover, blood transfusion requirements were significantly decreased in the sclerotherapy group. This was true even for patients who were bleeding at the time of randomization or who were in Child's class C, but this primarily was because fewer patients who underwent sclerotherapy (10 of 24 vs 18 of 23) required transfusions. Although there was no difference in survival between the two groups, we conclude that sclerotherapy is better than conventional treatment in the acute management of variceal bleeding. (<i>JAMA</i>1986;255:497-500)
SCARLET FEVER AND THE DICK TEST
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal