tbuckley/cabot-search huggingface dataset:
Impact of Diet on Lead in Blood and Urine in Female Adults and Relevance to Mobilization of Lead from Bone Stores
Authors: Brian L. Gulson, Kathryn R. Mahaffey, C. William Jameson, Nicole Patison, Alistair J. Law, Karen J. Mizon, Michael J. Korsch, David Pederson
Journal: Environmental Health Perspectives (1999)

We measured high precision lead isotope ratios and lead concentrations in blood, urine, and environmental samples to assess the significance of diet as a contributing factor to blood and urine lead levels in a cohort of 23 migrant women and 5 Australian-born women. We evaluated possible correlations between levels of dietary lead intake and changes observed in blood and urine lead levels and isotopic composition during pregnancy and postpartum. Mean blood lead concentrations for both groups were approximately 3 microg/dl. The concentration of lead in the diet was 5.8 +/- 3 microg Pb/kg [geometric mean (GM) 5.2] and mean daily dietary intake was 8.5 microg/kg/day (GM 7.4), with a range of 2-39 microg/kg/day. Analysis of 6-day duplicate dietary samples for individual subjects commonly showed major spikes in lead concentration and isotopic composition that were not reflected by associated changes in either blood lead concentration or isotopic composition. Changes in blood lead levels and isotopic composition observed during and after pregnancy could not be solely explained by dietary lead. These data are consistent with earlier conclusions that, in cases where levels of environmental lead exposure and dietary lead intake are low, skeletal contribution is the dominant contributor to blood lead, especially during pregnancy and postpartum.
Sector Resection With or Without Postoperative Radiotherapy for Stage I Breast Cancer: A Randomized Trial
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Sector Resection With or Without Postoperative Radiotherapy for Stage I Breast Cancer: A Randomized Trial Get access The Uppsala-Örebro Breast Cancer Study Group The Uppsala-Örebro Breast Cancer Study Group Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 4, 21 February 1990, Pages 277–282, https://doi.org/10.1093/jnci/82.4.277 Published: 21 February 1990 Article history Received: 11 July 1989 Revision received: 02 November 1989 Accepted: 08 November 1989 Published: 21 February 1990
TNM System
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eradicating Polio
Authors: David L. Heymann, R. Bruce Aylward
Journal: New England Journal of Medicine (2004)

During the past 12 months, poliovirus has been spreading to states in Nigeria that were previously free of poliomyelitis. Moreover, global surveillance for acute flaccid paralysis1 — involving the genomic sequencing of each wild poliovirus that is detected — has demonstrated that wild poliovirus genetically linked to parent viruses in northern Nigeria has spread to 12 other previously polio-free countries in sub-Saharan Africa.Rumors of "contaminated" polio vaccine ignited a controversy in Kano State, in northern Nigeria, in mid-2003 and led to the immediate and official suspension of immunization activities. Such rumors — the substance of which varies from the . . .
Recent Opinions of the Judicial Council of the American Medical Association
Journal: JAMA (1984)

The text is provided of six opinions, or interpretations, of the American Medical Association's Principles of Medical Ethics, that were approved by the Judicial Council after the publication of the 1982 edition of Current Opinions of the Judicial Council of the American Medical Association. The opinions deal briefly with the physician's ethical responsibilities in relation to accreditation of health facilities and programs, screening of semen donors for use in artificial insemination, safeguarding of confidentiality in the physician patient relationship, genetic counseling, in vitro fertilization, interprofessional relations with nurses, and sports medicine.
Presidential Address
Authors: CHARLES F. MARTIN
Journal: Annals of Internal Medicine (1929)

Article1 July 1929Presidential AddressCHARLES F. MARTINCHARLES F. MARTINSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI speak no mere formal commonplace when I say that no man who has been made president of the American College of Physicians can feel other than deeply sensible of the honor conferred upon him, and humbly aware of the great responsibility which the acceptance of the office entails. When we remember that one of the finest assets of this Athens of America is its noble medical tradition and a great professional heritage and that the first president of this College was a graduate of Harvard University, we are warranted in feeling that a peculiar fitness attaches to our holding... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal, Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes mellitus complicated by Addison’s disease; case report with a review of the literature 1 July 1929Volume 3, Issue 1Page: 1-5KeywordsEmotionsGraduate medical education ePublished: 1 December 2008 Issue Published: 1 July 1929 PDF downloadLoading ...
Adynamic ileus following induced hypotension
Authors: William E. R. Greer, Robert P. Giovacchini
Journal: JAMA (1985)

<h3>To the Editor.—</h3> We read with interest the article entitled "Sudden Death in Adolescents Resulting From the Inhalation of Typewriter Correction Fluid"<sup>1</sup>in the March 15,1985, issue of<i>JAMA</i>. Your readers should be made aware that children perverting the use of commercially available consumer products ("sniffing") has become a worldwide problem. A recent issue of the<i>British Medical Journal</i><sup>2</sup>reported 282 deaths in the United Kingdom from abuse of volatile substances during 1971 to 1983. The substances abused were gas fuels (24%), aerosol sprays (17% ), solvents in glue (27%), and other volatile substances such as cleaning agents (31%). In 51% of the cases the authors reported that death was attributed to the direct toxic effects of the substances abused. Therefore, we must disagree with the authors. There is nothing unique about correction fluid deaths when the product's use is perverted. There appears to be a gasoline sniffing epidemic
Delayed chloroquine retinopathy.
Journal: BMJ (1967)

mating to the normal diploid value seem to be relatively less active.Hitherto it has often been difficult to ensure that sufficiently representative tissue has been obtained at biopsy to allow a reliable estimate of invasion, but with this new method it seems that the difficulty has at least been partly overcome.Unfortunately with existing techniques only about one-half of the tumours examined have shown sufficient mitotic activity on which to base an opinion, but there can be little doubt that any positive information gained has amplified the histological picture.
ANTIPNEUMOCOCCIC SERUM.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 179: M6A demethylation enzyme FTO upregulates LDHA and promotes glycolysis and invasion and migration in oral squamous cell carcinoma
Authors: Jinsong Hou
Journal: Cancer Research (2019)

Abstract Objective: To investigate the role of lactate dehydrogenase A (LDHA) in the glycolysis and invasion and metastasis of oral squamous cell carcinoma (OSCC), and to explore the molecular mechanism of fat mass and obesity-associated protein (FTO) regulating LDHA on the glycolysis and invasion and metastasis of OSCC. Methods: Immunohistochemistry and RT-qPCR were performed to detect the expression of LDHA protein and gene in OSCC and adjacent non-cancerous tissues, and their correlation with clinical prognosis and pathological parameters were analyzed. Lentivirus-mediated shRNA silencing of LDHA and lactate dehydrogenase inhibitor (oxamate) were used to establish stable OSCC Cell lines HSC3 and SCC15, Cell Counting Kit-8 and colony formation assay were applied to evaluate cell proliferation, scratch test and Transwell assay were performed to detect cell migration and invasion, Glucose utilization assay and Lactate production assay were carried out to assess cell uptake of glucose and lactate production respectively. The molecular mechanism of FTO regulating LDHA on glycolysis, invasion and metastasis of oral squamous cell carcinoma was further explored, OSCC cell lines HSC3 and SCC15 transfected with siRNAs to silence FTO expression, EpiQuik™ m6A RNA Methylation Quantification Kit was applied to assess the m6A% in total RNA, the effect of FTO on LDHA expression was detected by Western blot and RT-qPCR. The biological function of FTO on oral squamous cell carcinoma cells was demonstrated by cell experiments in vitro. Results: Compared with adjacent non-cancerous tissues, LDHA was highly expressed in OSCC (P&amp;lt;0.001), which was closely related to the differentiation, clinical stage and T stage of OSCC (P&amp;lt;0.05). Silencing LDHA, FTO or treating oxamate in HSC3 and SCC15 cells reduced glucose consumption, lactate production and cell proliferation, invasion and migration (P&amp;lt;0.05). In addition, after FTO silencing, the m6A level of total RNA increased (P&amp;lt;0.05), while the expression level of LDHA protein and mRNA decreased (P&amp;lt;0.01). Conclusion: FTO may promote the expression of LDHA protein and mRNA in a m6A-dependent manner and enhance the ability of glycolysis, proliferation, invasion and metastasis of OSCC. Note: This abstract was not presented at the meeting. Citation Format: Jinsong Hou. M6A demethylation enzyme FTO upregulates LDHA and promotes glycolysis and invasion and migration in oral squamous cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 179.
Specialist Physician Practices as Patient-Centered Medical Homes
Journal: New England Journal of Medicine (2011)

were known to be diploid for chromosomes 12 and 14 were also sequenced as reference libraries.Using our previously described method, 2 we determined whether the maternal sample (PL565) was diploid in each of 22 nonoverlapping 4-Mb regions on chromosomes 12 and 14 through a pairwise comparison with each of the reference libraries.We detected a 4-Mb depletion in DNA copy number on chromosome 12p in PL565 in all seven pairwise comparisons with a normal sample (adjusted P≤0.05 for all comparisons) (Fig. S1 in the Supplementary Appendix, available with the full text of this letter at NEJM .org).Tests for all other 21 regions resulted in nonsignificant adjusted P values for all seven pairwise comparisons (Table S1 in the Supplementary Appendix).
Statistics Notes: Measurement error
Authors: J M. Bland, D. G Altman
Journal: BMJ (1996)

We report on four children of both sexes from a highly inbred family with hypotonia, spastic diplegia, microcephaly, microphthalmia, congenital cataract, optic atrophy, ptosis, kyphoscoliosis, short stature, severe mental retardation, and cerebral malformations. Six other children may also have been affected. The differential diagnosis and the possibility of a second family with the micro syndrome are discussed.
KIDNEY PATHOLOGY AND RENAL FUNCTION
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of the Decipher prostate cancer classifier to predict metastasis and disease-specific mortality from genomic analysis of diagnostic prostate needle biopsy specimens.
Authors: Paul L. Nguyen, Zaid Haddad, Lucia L.C. Lam, Kaye Ong, Christine Buerki, Samineh Deheshi, Kasra Yousefi, Elai Davicioni, Jeffrey J. Tosoian, Tamara L. Lotan, Felix Yi-Chung Feng, Bruce J. Trock, Ashley Ross, Eric A. Klein
Journal: Journal of Clinical Oncology (2017)
Congenital rubella affecting an infant whose mother had rubella antibodies before conception
Authors: J. M Best, G. C Harcourt, J E Banatvala, T H Flewett
Journal: BMJ (1981)

V. FIG 2-Needle biopsy specimen of liver six months after stopping herbal challenge.The inflammatory changes shown in fig 1 have resolved.authenticated.2 Mistletoe, however, contains several potential toxins (P-phenylethylamine, tyramine, acetylcholine, and propionylcholine).The herbal tablets used by our patient contained 90 mg mistletoe extract, which is not a large dosefor example, Potters' Cyclopaedia of Botanical Drugs and Preparations recommends 2-8 g.We have found no record of any toxic reactions to mistletoe in man, and it has not been implicated in drug-induced hepatitis,3 though other herbs may cause severe liver injury.4 5 Although mistletoe was the most likely toxin in this case, we thought that trying to obtain definitive proof with a second challenge test using mistletoe extract alone was not justifiable because of the severity of the histological change after the first challenge test.Mistletoe is widely used in herbal remedies and until May 1978 a bronchodilator preparation (Felsol) containing mistletoe extract was listed in MIMS.Herbal remedies may be purchased without prescription and are much more commonly consumed than many doctors realise.This case shows that active hepatitis may result from their consumption, but there may well be cases in which the hepatitis remains subclinical and so progresses insidiously.Herbal remedies might also be an aetiological factor in the development of so-called cryptogenic cirrhosis.
PARIS LETTER.
Authors: None A. B.
Journal: JAMA (1885)

Paris, December 3, 1884. You will have learned of the decline of the cholera epidemic in Paris, and it may be interesting to take a retrospective view of it from its outbreak in the beginning of November. Dr. Emile Rivière read a paper at the meeting of the Academy of Sciences last week, in which he entered into a history of the epidemic, and of which the following is a summary: According to the reports published under the orders of the Prefect of Police, the first case of cholera was reported on the 4th of November. The next day six cases occurred, and were at once sent to the hospital, where five of them died next day. From the 5th to midnight of the 22d of November, 912 patients were conveyed to the hospitals (553 men and 359 women), 59 cases occurred in the hospitals, of which 18 were employés
Incidence of rejection and infection after liver transplantation as a function of the primary disease: Possible influence of alcohol and polyclonal immunoglobulins
Authors: O Farges, F Saliba, H Farhamant, D Samuel, A Bismuth, M Reynes, H Bismuth
Journal: Hepatology (1996)

A retrospective analysis was undertaken to determine if the incidence, timing, and severity of acute and chronic rejection were influenced by the primary disease necessitating transplantation. Of the 875 liver transplantations performed between 1984 and 1992, 768 were primary transplantations and 107 were retransplantations. Among the former, 330 patients that were liver transplant recipients for a chronic liver disease without cancer in the native liver received an ABO-compatible and cross-match-negative graft and were given a cyclosporine- or tacrolimus-based immunosuppression. These included primary biliary cirrhosis (PBC, 66 patients), primary sclerosing cholangitis (PSC, 23 patients), alcoholic cirrhosis (ALC, 21 patients), autoimmune cirrhosis (AIC, 17 patients), hepatitis B virus-induced cirrhosis (HBV-C, 116 patients) and hepatitis C virus-induced cirrhosis (HCV-C, 87 patients). The incidence of acute (48% ± 3% [SE] at 1 year) and chronic rejection (10% ± 2% at 3 years) was comparable in patients who have undergone transplantation for PBC, PSC, AIC, and HCV-C. However, the incidence of acute (but not chronic) rejection was significantly lower in patients who have undergone transplantation for ALC (29% at 1 year). This reduced incidence of acute rejection was associated with an increased incidence of bacterial infections. In patients who have undergone transplantation for HBV-C (the majority of whom had received long-term anti-hepatitis B surface antigen [HBs] immunoglobulins), the incidence of both acute (21% at 1 year) and chronic rejection (0% at 3 years) was significantly lower, whereas the incidence of septic complications was comparable with that in the other groups. The incidence of acute rejection in patients who have undergone transplantation for nonviral disease receiving polyclonal human anti- cytomegalovirus (CMV) immunoglobulins was also significantly lower than that of patients who did not receive the immunoglobulins (19% vs. 48% at 3 months; P = .01), and this was identical to that of patients who have undergone transplantation for viral disease receiving polyclonal human anti-HBs immunoglobulins (19% at 3 months). These results show that the risk of rejection is unequal among patients, being lower in patients who have undergone transplantation for ALC (probably as a result of a state of nonspecific hyporesponsiveness) and in patients who have undergone transplantation for HBV-C (possibly as a result of long-term administration of polyclonal human immunoglobulins).
Rambling Notes of a Roving Doctor
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ovarian Physiology
Authors: George S. Richardson
Journal: New England Journal of Medicine (1966)

Steroidogenesis by the OvaryThe schema of steroidogenesis generally considered to be applicable with only slight modification to all steroid-forming tissue is shown in Figure 2. The steps from pregnenolone‡ onward have a complexity that is due to the permutations and combinations of about 6 types of chemical reactions at 11 sites on the molecule. When the steroid carbons are considered in numerical sequence as shown in Figure 3, the important reactions are as follows:1. At positions 3 and 5: The change from the 3β-hydroxyl, 5 double bond (as in cholesterol) to the 3-ketone, 4 double bond, or Δ4–3 ketone . . .
Queries and Minor Notes
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal