tbuckley/cabot-search huggingface dataset:
PROTECTION AGAINST IRRADIATION
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of hyperlipidemia in women
Authors: J. M. Walsh
Journal: JAMA (1995)

<h3>Objective.</h3> —To assess the evidence that lipid lowering prevents coronary heart disease (CHD) events in women. <h3>Data Sources.</h3> —English-language literature assessing the effects of cholesterol lowering with dietary and/or drug interventions as primary or secondary prevention on CHD events in women. <h3>Main Outcome Measures.</h3> —Coronary heart disease and total mortality were the primary outcomes assessed. Angiographic regression of coronary atherosclerosis was a secondary outcome. <h3>Study Selection, Data Extraction, and Data Synthesis.</h3> —All nine of the identified studies that met the criteria were included. Relative risks for CHD and total mortality were calculated from available data. Summary relative risks were calculated using meta-analytic techniques. <h3>Conclusions.</h3> —There is no evidence from primary prevention trials that cholesterol lowering affects total mortality in healthy women, although the available data are limited. Limited evidence suggests that treatment of hypercholesterolemia in women with coronary disease may decrease CHD mortality. Future research should address the role of dietary and other nondrug treatment of hypercholesterolemia in women at high risk for CHD. (<i>JAMA</i>. 1995;274:1152-1158)
East River Reflections
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
An element of pleasure
Authors: S. Vaisrub
Journal: JAMA (1978)

Medicinal uses of zinc, which began centuries ago with the fumbling empiricism of local therapy for wounds and various skin lesions, is now entering an era of oral and parenteral therapy based on indications of specific deficiency in need of replenishment. Zinc has proved effective in acrodermatitis enteropathica of genetic origin<sup>1</sup>as well as in the acquired variant associated with prolonged intravenous alimentation.<sup>2</sup>Watery diarrhea and skin lesions characteristic of these zincdepleted states have responded well to replacement therapy as have the syndrome of growth retardation and hypogonadism reported from the Middle East<sup>3</sup>and in similar malfunctions complicating sickle cell disease.<sup>4</sup>Improvement with zinc has also been noted in refractory cases of celiac disease<sup>5</sup>and in children with protein-energy malnutrition whose zinc-deficient state is associated with thymic atrophy and susceptibility to infection.<sup>6</sup>True to its first love, the skin, zinc still maintains its precarious contact
The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness
Authors: Geethu Emily Thomas, Grace Egan, Laura Garcia Prat, Boaz Nachmias, Jordan M Chin, Fieke W Hoff, Kerstin Kaufmann, Rose Hurren, Marcela Gronda, Neil MacLean, Xiaoming Wang, Veronique Voisin, Aaron Botham, Andrea Arruda, Mark D. Minden, Gary D Bader, Steven M. Kornblau, John E. Dick, Aaron D Schimmer
Journal: Blood (2019)
Phylogenetic analysis of hepatitis C virus isolates and their correlation to viremia, liver function tests, and histolog
Authors: S Zeuzem
Journal: Hepatology (1996)

Nucleotide sequence analysis of hepatitis C virus (HCV) strains showed substantial variability leading to a classification into several genotypes and subtypes. The data correlating HCV genotypes and subtypes with hepatitis C viremia levels, demographic characteristics of patients (age, mode of transmission, duration of infection), and severity of liver disease are conflicting. The interpretation of several studies is further complicated because the molecular methods used lacked specificity for genotyping/subtyping and underestimated viremia levels, especially in patients infected with HCV genotypes 2 and 3. In the present study we investigated 97 consecutive patients with chronic hepatitis C using molecular “gold standard” methods. HCV subtyping was performed by sequence and phylogenetic analysis of the nonstructural (NS)-5 region and serum HCV-RNA concentration was assessed by a validated genotype-independent quantitative reverse- transcription-polymerase chain reaction assay using an internal RNA standard. Patients infected with subtypes HCV-1b, HCV-2a-c, and HCV-4 were older than patients infected with HCV-1a and HCV-3a. Serum HCV-RNA levels ranged from 1.5 × 104 to 1.0 × 108 copies/mL with no significant differences between median serum HCV-RNA concentrations in patients infected with different genotypes/subtypes. Although patients infected with HCV-1b were older, no biochemical or histological evidence was obtained that this subtype is associated with more severe liver disease. Furthermore, the present study showed a lack of correlation between the serum HCV-RNA concentration, biochemical parameters, and liver histology. The median serum HCV-RNA levels in patients with chronic persistent hepatitis, chronic active hepatitis, and liver cirrhosis were 5.0 × 106 copies/mL, 2.5 × 106 copies/mL, and 5.0 × 106 copies/mL, respectively. These differences were not significant. In conclusion, using optimized and validated molecular techniques, the present cross-sectional study showed no correlation between HCV genotypes/subtypes, viremia, liver function test results, and histology.
Syringe and Needle Regulation, Blood-Borne Disease Transmission, and Concern for Public Safety
Authors: Elizabeth A. Roaf
Journal: JAMA (1997)

—We are all for preventing IDUs from contracting deadly blood-borne diseases and, therefore, fully support creation and expansion of syringe exchange programs. However, repeal of syringe regulation laws and practice guidelines as outlined by Gostin and colleagues<sup>1</sup>is a dangerous and illconceived solution. Granting access to an endless supply of needles to society's most irresponsible members is as preposterous as it is unthinkable. Possession of hypodermic needles carries a serious responsibility to dispose of them safely. Trusting an IDU to fully carry out this responsibility is both foolish and naive. Injecting drug users are by legal definition criminals, by medical definition addicts who are unable to control their own impulses and actions, and by society's definition the very letter of irresponsibility. Beyond the physician's responsibility to IDUs is our responsibility to protect the public at large. No doubt, trash collectors and beachgoers, among the persons most assuredly at risk to
Neuromuscular Effects of Diallylnortoxiferine in Anesthetized Subjects
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Your Arthritis: What You Can Do About It
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Rhode Island Medical Society
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<b>Zika virus</b>
Authors: Marina Basarab, Conor Bowman, Emma J Aarons, Ian Cropley
Journal: BMJ (2016)

Zika virus is spreading rapidly in the Americas.The virus was identified in the late 1940s in Africa but was first confirmed in Brazil in May 2015.It has since been identified in more than 27 countries and territories in the region. 1 2 Spread to the Americas was predicted because of the abundance of the mosquito vector, Aedes aegypti. [3]4][5][6] Clinicians worldwide need to be aware of Zika virus infection owing to international travel and the presence of another potentially competent mosquito vector (Aedes albopictus) in North America and southern Europe.Some Brazilian regions experiencing outbreaks of Zika infection have reported an apparent increase in congenital microcephaly and post-infective neurological syndromes, particularly Guillain-Barré syndrome (see boxes 1 and 2). 2 The association of these conditions with Zika virus infection is currently unproved and is under investigation.On 1 February 2016, the World Health Organization declared the recent cluster of microcephaly and other neurological disorders reported in Brazil, following a similar cluster in French Polynesia in 2014, a public health emergency of international concern. 7If Zika virus infection is confirmed to cause congenital microcephaly, this could lead to a large international burden of infant neurological morbidity.Zika virus infection should be considered in people presenting with compatible symptoms who have recently returned from countries where outbreaks of the infection are occurring.This review provides up to date information at the time of publication on Zika virus, its evolving epidemiology, how to recognise its clinical presentation, possible complications, and how to confirm the diagnosis.
Validation of a genomic classifier for prediction of metastasis following postoperative salvage radiation therapy.
Authors: Robert Den, Elai Davicioni, Voleak Choeurng, Lauren Howard, Amanda de Hoedt, Marguerite Du Plessis, Kasra Yousefi, Lucia L.C. Lam, Christine Buerki, Edouard John Trabulsi, Adam Dicker, Jeffrey Karnes, Stephen J. Freedland
Journal: Journal of Clinical Oncology (2015)

5016 Background: Management of patients with a postoperative rising prostate-specific antigen (PSA) level is complex. Additional local treatment such as salvage radiation therapy (SRT) may be sufficient for many patients but some may require concurrent systemic therapy in order to delay or prevent metastatic disease. As PSA recurrence on its own is a poor surrogate for metastatic disease we hypothesized that the Decipher genomic classifier (GC), a validated predictor of metastasis may be able to better distinguish those patients where additional local therapy is beneficial from those where SRT on its own is likely insufficient. Methods: Genomic classifier (GC) scores were calculated from 166 prostate cancer patients, who received SRT at the Veteran Affairs Medical Center Durham, Thomas Jefferson University and Mayo Clinic, between 1990 and 2010. SRT was defined as administration of RT with Pre-RT PSA levels > 0.2 ng/ml. GC and CAPRA-S scores were compared using survival c-index, competing-risks and Cox regression analysis for the prediction of metastasis. Results: Survival c-index for predicting metastasis 5 years post SRT was 0.87 (95% CI: 0.73-0.90) for GC and 0.62 (95% CI: 0.48-0.77) for CAPRA-S. The cumulative incidence of metastasis at 5 years post-SRT was 2.8%, 5.8%, and 33.5% for low, average, and high GC scores (p < 0.0001) and 17%, 2.3% and 15% for low, average and high CAPRA-S scores (p = 0.19). In univariable analysis only GC, extraprostatic extension and Pre-RT PSA were significant predictors of metastasis. In multivariable analyses with clinical risk factors or the CAPRA-S nomogram, GC was the only independent predictor of metastasis with a HR of 1.59 (1.17-2.16, p = 0.0017) for a 10% unit increase in risk score. Conclusions: In patients treated with postoperative SRT for PSA recurrence, GC is a powerful predictor of metastasis. Patients with low Decipher have excellent prognosis with SRT and may avoid concurrent hormone therapy. Patients with high Decipher risk are at highest risk for metastatic disease and SRT failure and may benefit from concurrent systemic therapy.
A new rat bile ductular epithelial cell culture model characterized by the appearance of polarized bile ducts in vitro
Authors: A Sirica
Journal: Hepatology (1997)

The rat treated with bile duct ligation (BDL) and furan is a unique animal model of massive bile ductular hyperplasia in which normal liver parenchyma is largely replaced with well-differentiated proliferated bile ductules. We have now developed a simple cell isolation procedure to obtain and culture viable bile ductular epithelial cells in high numbers and with a high degree of purity from the livers of BDL/furan-treated rats. Primary monolayer cell cultures were readily established when the isolated bile ductular epithelial cells were cultured in plastic tissue culture wells coated with rat tail tendon type I collagen plus bovine plasma fibronectin. Under these conditions, epidermal growth factor (EGF) was mitogenic for the cultured cells, and they retained phenotypic features typical of hyperplastic bile ductular epithelium but did not show evidence of ductal morphogenesis in vitro. In contrast, when the isolated bile ductular cells were cultured for 7 to 16 days in the presence of 25 ng EGF/mL and 10% fetal bovine serum on type I collagen gels, they formed into branching ductal structures whose ultrastructural features very closely resembled those of polarized hyperplastic bile ductules/ducts in vivo. Histological preparations of these gel cultures further showed that numerous ductal structures with defined lumens were present. Phenotypically, these ductal structures were completely surrounded by a thickened basement membrane that was strongly immunoreactive for laminin. Like their in vivo biliary cell counterparts, the epithelial cells comprising these ductal structures in culture also exhibited strong immunocytochemical staining reactions for cytokeratins 8 and 19, for glutathione S-transferase pi 7, and for luminal gamma-glutamyl transpeptidase, but they did not express immunoreactive albumin or alpha-fetoprotein. Occasional epithelial cells of the ductal structures, when examined in 10-day-old primary gel culture, showed strong nuclear staining for incorporated 5-bromo-2'deoxyuridine, indicating active cell proliferation. Our results support the development of a novel biliary epithelial cell culture model that has the potential of serving as a powerful tool for investigation of factors that regulate hyperplastic bile ductular morphogenesis, cell proliferation, and polarized cell functions in a structural form in vitro that mimics that of hyperplastic bile ductules induced in vivo. (Hepatology 1997 Sep;26(3):537-49)
Diagnostic and Prognostic Significance of the Alternatively Spliced ACTN4 Variant in High-Grade Neuroendocrine Pulmonary Tumours
Authors: A. Miyanaga, K. Honda, K. Tsuta, M. Masuda, H. Tsuda, H. Asamura, A. Gemma, T. Yamada
Journal: Annals of Oncology (2012)
Book Review Total Knee Replacement Edited by Richard S. Laskin. 268 pp., illustrated. New York, Springer-Verlag, 1991. $149. 0-387-19644-7 Knee Pain and Disability Third edition. By Rene Cailliet. 287 pp., illustrated. Philadelphia, F.A. Davis, 1992. $19.95. 0-8036-1622-8 An Illustrated Guide to the Knee By Alfred J. Tria, Jr., and Kenneth S. Klein. 168 pp., illustrated. New York, Churchill Livingstone, 1992. $59.95. 0-443-08794-6 Knee Ligaments: Clinical Examination By Guy Liorzou. 108 pp., …
Authors: Donald B. Goodfellow
Journal: New England Journal of Medicine (1993)
Pediatric Trauma
Authors: John H. van de Leuv
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The COMMENTARY on pediatric trauma (1983;249:47) deserves some reaction. The piece is well done and reiterates what emergency physicians already knew. What is constantly amazing to me is the assumption that a well-staffed, experienced emergency department team cannot deal adequately with pediatric trauma; we do it often and have few problems. Furthermore, the Advanced Trauma Life Support course is not needed by experienced emergency physicians or trauma surgeons. For the same reason, an Advanced Pediatric Life Support course would be needed by those who only sporadically handle pediatric trauma and, more importantly, by those in the prehospital care field. If we are to save injured children, it is extremely important to ensure adequate care in the prehospital phase. The concept of a pediatric regional trauma center is a worthwhile one. It might be better to attach such a unit to a children's hospital and, where such a