tbuckley/cabot-search huggingface dataset:
Abstract 1721: Deletion of Both Macrophage ABCG1 and ApoE Independently Promotes Atherosclerotic Lesion Development in LDL Receptor Knockout Mice
Authors: Ruud Out, Bart Lammers, Reeni B. Hildebrand, Carmel M. Quinn, David Williamson, Menno Hoekstra, Illiana Meurs, Theo J.C. Van Berkel, Wendy Jessup, Miranda Van Eck
Journal: Circulation (2008)

Objective ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein E (apoE) play a role in macrophage cholesterol efflux and consequently the development of atherosclerosis. Although a possible interaction between ABCG1 and apoE in cholesterol efflux was postulated, the combined action of these proteins in atherosclerosis is still unclear. Methods and Results LDL receptor knockout (KO) mice were transplanted with bone marrow from ABCG1/apoE double KO (dKO) mice, their respective single knockouts, and wild-type (WT) controls. After feeding a high-fat/high-cholesterol diet for 6 weeks, no differences were found in serum lipid levels. However, the mean atherosclerotic lesion area in dKO transplanted animals (187 ± 18 × 10 3 μ m 2 ) was 1.4-fold (p &lt; 0.01) increased compared to single knockouts (ABCG1 KO: 138 ± 5 × 10 3 μm 2 ; apoE KO: 131 ± 7 × 10 3 μm 2 ) and 1.9-fold (p&lt; 0.001) as compared to WT controls (97 ± 15 × 10 3 μm 2 ). In vitro cholesterol efflux experiments confirmed that combined deletion of ABCG1 and apoE resulted in a larger attenuation of macrophage cholesterol efflux to HDL as compared to single knockouts. Conclusions Deletion of macrophage ABCG1 or apoE does lead to a moderate increase in atherosclerotic lesion development while combined deletion of ABCG1 and apoE induces a more dramatic increase in atherosclerosis. These results indicate an added, independent effect for both macrophage ABCG1 and apoE in atherosclerosis.
JAMA Pediatrics
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Nicole Balin, Miriam Cintron, Paul Ruich, Diane Cannon, Connie Manno, Fred Marshall, Laura Copyreaders, Catherine Adamczyk, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Roya Glitman, Laura Khatiblou, Donna King, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Lenette Gardner-Gullens, Fanny Brown, Paul Frank, Peter Kim, Rachell Lozano, Michaela Mark, Kathryn Muskovich, Gale Saulsberry, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Will English, Christopher Hastings, Craig Mccaffrey, Reuben Rios, Ronna Henry, Joshua Bird, Karen Bucher, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Staff, Monica Smith, Jeffery Bonistalli Manager, Kathy Russell, Mirna Monal, Tim Melroy, Thalia Moss, Mike Harvey, Susan Henning, Mark Thornbury, Tricia Castellano, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Irma Millie, Lara Marketing, Matt Herron, Elizabeth Solaro, Geoffrey Flick, Paul Gee Managers, Rick Bell, Lindsay Dawson, Michael Mcgraw, Sara Nagy, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Sue Sherrill, Brian Shields Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Jaye Mize, Annemarie Neff, J Neff, Sean O'donnell, Sean Ohlson, Phil O'leary, Susan Price, Denise Steinhauser, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Dimitri Christakis, Alain Joffe, Ron Keren, Suzanne Shuey, Benjamin French, Peter Cummings, Samir Shah, Howard Bauchner, Frederick Rivara, Joyce Lee, Ann Arbor, Jay Berry, Cherrie Boyer, San Francisco, Maria Britto, John Campo, Aaron Carroll, Indiana Frank, Joseph Chaloupka, Mitchell Cohen, Kathleen Janz, Iowa City, Terry Klassen, Michigan Michelle, Huckaby Lewis, Aaron Milstone, Shawn Rangel, Martha Sola-Visner, Jean-Claude Carel, Shabir Madhi, Ben Marais, Frank Oberklaid, Susan Sawyer, Joan-Carles Surís
Journal: JAMA Pediatrics (2014)
UNITED KINGDOM
Journal: JAMA (1963)

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The World in Medicine
Authors: Rebecca Voelker
Journal: JAMA (1997)

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Syphilis du testicule.
Journal: JAMA (1927)

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Phase II study of induction therapy with gemcitabine and nab-paclitaxel followed by consolidation with mFOLFIRINOX in patients with metastatic pancreatic cancer.
Authors: Ramesh K. Ramanathan, Peter Lee, Joseph W. Leach, Stephen Patrick Anthony, Glen J. Weiss, Peter J. Rosen, Vincent J. Picozzi, Jasgit C. Sachdev, Tim Larson, Ronald Korn, Chengcheng Hu, Gayle S. Jameson, Amy C. Stoll, Daniel D. Von Hoff, John E. Seng
Journal: Journal of Clinical Oncology (2013)

233 Background: We designed a phase II study to evaluate the efficacy, toxicity and feasibility of administering nab-paclitaxel/gemcitabine (NabP-Gem) followed by mFOLFIRINOX in MPC. Methods: Eligible patients had evidence of untreated MPC with performance status of ECOG 0-1 and adequate organ function. Induction therapy was with Nab-P (125 mg/m 2 ) and Gem (1000 mg/ m 2 ) weekly x 3 every 4 weeks for a maximum of 6 months (6 cycles). mFOLFIRINOX every 2 weeks (Consolidation regimen) was initiated after 6 cycles of the Induction regimen, or earlier in case of progression, and given upto 6 months (12 cycles). The FOLFIRINOX regimen (NEJM,364:1817-25: 2011) was modified to omit the bolus 5FU and requires addition of granulocyte growth factor prophylaxis. A primary endpoint is to increase 1 year survival (n=30) to &gt;70%, (95% confidence intervals for one year survival rate is +/- 20%). Results: As of 9/1/2012, 26 of 30 subjects have been accrued. M/F ratio is 58%/42%, median is 65 years. In 20 patients treated on the induction phase, 75% have a &gt; 90% decrease in CA 19-9 levels. The partial response rate (PR) in the first 19 patients who have completed 4 cycles is 50%. Early image analysis on 9 subjects with concurrent CT and PET showed 44% PR (RECIST 1.1) but 89% by CHOI and PET criteria. A novel approach to interrogate tumor texture composition demonstrated substantial change in lesion texture following induction therapy. To date selected Grade &gt; 3 adverse events are neutropenia (n=8), fatigue (n=5), thromboembolic events (n=4), peripheral neuropathy (n=3), dehydration (n=2), anemia (n=3), thrombocytopenia (n=2), febrile neutropenia (n=2) and myalgias (n=2). Among 26 patients who have received at least one cycle of NabP-Gem, ten dose reductions and four dose delays were seen. To date, 11 patients have begun the Consolidation regimen with mFOLFIRINOX. Conclusions: The induction NabP-Gem regimen shows preliminary evidence of substantial activity similar to published reports (JCO.29:4548-54: 2011). Study will now evaluate the safety, efficacy and feasibilty of the Consolidation regimen with mFOLFIRINOX. Supported by the Seena Magowitz Foundation. Clinical trial information: NCT01488552.
Hypokalemic rhabdomyolysis and myoglobinuria following amphotericin B therapy
Authors: D. J. Drutz
Journal: JAMA (1970)

Amphotericin B-induced hypokalemia progressed to profound muscle weakness, rhabdomyolysis, and myoglobinuria in a patient with cryptococcal meningitis. Incomplete renal tubular acidosis which was present during therapy may have predisposed the patient to renal potassium wasting.
Notes on Books
Journal: BMJ (1888)

He likewise observed that where the body is methodically flooded by the mineral water, the circulation of the lymph in the tissues is quickened, the organic activity is increased, and in the more copious amounts of fluid poured out at the kidneys, concrements of different kinds may be eliminated.Further, the peristaltic activity of the in- testines is heightened in a painless fashion, leading to niore copious motions without diarrhcea.
SOCIETY NEWS.
Journal: JAMA (1896)

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ABDOMINAL PREGNANCY.
Authors: JOHN C. MURPHY
Journal: JAMA (1907)

<h3>Patient.</h3> —Mrs. J. S., aged 28, was seen June 2, 1907, and the following history obtained: <h3>History.</h3> —Married in 1903, always enjoyed perfect health. No history of pelvic disease. Menstruation regular until July, 1906, when menstruation ceased. Soon the usual symptoms of pregnancy appeared. Fetal movements were manifest in December, continuing till April, 1907. About April 14, pains simulating normal labor occurred, followed by a bloody and vaginal discharge. Her physician told her the normal period for labor had not arrived and gave sufficient morphin to stop the pains. From this time all fetal activity ceased and the general health of the patient became bad. May 21 three physicians in consultation decided that the woman was not pregnant (despite her insistence to the contrary), but was suffering from abdominal dropsy, and arrangements were made to tap the abdomen the following day. This operation the patient declined. When I saw her
Contents
Authors: Maria Woodward, Taylor Blachley, Joshua Stein, Jeffrey Whitman, Paul Dougherty, Gregory Parkhurst, John Olkowski, Stephen Slade, John Hovanesian, Ralph Chu, Jon Dishler, Dan Tran, Robert Lehmann, Harvey Carter, Roger Steinert, Douglas Koch, Edward Wladis, Elizabeth Bradley, Jurij Bilyk, Michael Yen, Louise Mawn, Christina Moon, Afshan Nanji, Anat Galor, Kathryn Mccollister, Carol Karp, Jay Erie, David Hodge, Michael Mahr, Arun Narayanaswamy, Mani Baskaran, Shamira Perera, Monisha Frcophth, Hla Nongpiur, Tin Htoon, Tina Tun, David Wong, Daniel Goh, Ed Su, Paul Chew, Ching-Lin Ho, Tin Aung, Carol Shields, Molly Marous, Mairghread Casey, Alexzandra Douglass, Chloe Khoo, Jerry Shields, Ralph Eagle, Piero Barboni, Giacomo Savini, Valerio Carelli, Nicole Balducci, La Morgia, Francesco Bandello, Alfredo Sadun, Anastasia Pilat, Frank Proudlock, Irene Gottlob
Journal: Ophthalmology (2016)
Hyperpiesia and Hyperpiesis (Hypertension). A Clinical, Pathological and Experimental Study.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multimodal Dose Dense Therapy for Mantle Cell Lymphoma.
Authors: Sam O. Wanko, Jon P. Gockerman, Joseph O. Moore, Carlos de Castro, Louis Diehl, Robert Pronitz, Cristina Gasparetto, John Chute, Mitchell Horwitz, Ashley Morris, Francis Ali-Osman, Arati Rao, Donna Niedzweicki, Gwynn D. Long, Nelson J. Chao, David A. Rizzieri
Journal: Blood (2005)
Misplaced Paragraph
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lung Biopsy
Authors: Z. Z. Godlowski
Journal: BMJ (1951)

The three-dimensional microarchitecture of the thymus plays a unique role in directing T cell lineage commitment and development. This is supported by the fact that, in contrast to fetal thymic organ cultures, thymic stromal cell monolayer cultures (TSMC) fail to support T lymphopoiesis. Nevertheless, OP9-DL1 cell monolayer cultures induce T lineage commitment and differentiation. Thus, the inability of TSMC to support T lymphopoiesis may be due to a loss of Notch ligand expression and/or function during culture. In this study, we report that, in contrast to fetal thymic organ cultures, TSMC fail to maintain expression of the Notch ligands, Delta-like (Dll) 1 and Dll4, and concomitantly lose the ability to support T lymphopoiesis. Importantly, ectopic re-expression of Dll1 or Dll4 is sufficient to restore the ability of TSMC to support T lymphopoiesis. These findings demonstrate that maintenance of endogenous Dll1 or Dll4 expression by thymic stromal cells is required for the commitment and differentiation of T cells in the absence of a three-dimensional microenvironment.
Abstract 2892: Genetic inhibition of STAT3 increases medulloblastoma chemosensitivity
Authors: Sutapa Ray, Donald Coulter, Phillip Wilder, Jason Sughroue, Nagendra Chaturvedi, Timothy Mcguire, Santharam Joshi, Graham Sharp, Kishor Bhakat, Angie Rizzino
Journal: Cancer Research (2019)

Abstract Medulloblastoma (MB) is the most common malignant brain tumor in children that arises from cerebellar neuronal progenitor cells. Post-surgical radiotherapy in combination with adjuvant chemotherapy are considered as standard treatment of care for MB. However, this long-term treatment often leads to harmful neurologic effects to the developing brain in children. Therefore, identification of novel therapeutic target to increase efficacy and reduce toxicity in MB represent an unmet clinical need. Signal transducers and activators of transcription-3 (STAT3) is constitutively activated in MB, where it functions as an oncoprotein, mediating cancer cell proliferation. Here, to evaluate the biological consequences of specific targeting of STAT3 in detail, we engineered MYC expressing Group 3 MB cells to stably express STAT3 shRNA under a doxycycline (Dox) inducible promoter and assessed the its effect on STAT3 function. Treatment of MB cells with Dox leads to growth inhibition and cell cycle arrest. Dox treatment downregulated expression of STAT3 and its target genes/proteins including MYC and delayed migration of MB cells. Expression of STAT3 shRNA decreased association of STAT3, BRD4, phospho-RNA Pol II to the proximal promoter of MYC and CCND1. It further downregulated occupancy of acetylated histone H3 K27 to the MYC and CCND1 promoter indicating gene repression. Moreover, we showed that combination Dox and cisplatin significantly decreased highly aggressive MYC-amplified MB cell growth and induced apoptosis by downregulating STAT3 regulated proliferation and anti-apoptotic gene expression. Together, our results revealed an important role of STAT3 in regulating MB pathogenesis. Disruption of this pathway with STAT3 inhibitor, therefore, may serves as a promising candidate for targeted MB therapy by enhancing chemo-sensitivity of MB cells, potentially improving outcomes in high-risk patients. Citation Format: Sutapa Ray, Donald Coulter, Phillip Wilder, Jason Sughroue, Nagendra Chaturvedi, Timothy Mcguire, Santharam Joshi, Graham Sharp, Kishor Bhakat, Angie Rizzino. Genetic inhibition of STAT3 increases medulloblastoma chemosensitivity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2892.
Poster Session 1: Mechanisms of Injury
Authors: Faiz Francis, Thomas Lowe, Matthew Johnson, David Agarwal, Daniel Wertman, Sabah Butty, Thomas Casciani, Irma Garcia-Martinez, Xinshou Ouyang, Nicola Santoro, Mark Shlomchik, Wajahat Mehal, Ji-Yuan Zhang, Dechun Feng, Shi-Ying Cai, Fu-Sheng Wang, Bin Gao, Juan Carlos, Jaime Bosch, Diana Hide, Marti Ortega-Ribera, Sergi Vila, Carmen Peralta
Journal: Hepatology (2014)

Purpose: To evaluate retrospectively the safety, technical success and clinical efficacy of hepatic vein stenting in the management of clinically evident hepatic venous outflow obstruction complicating orthotopic liver transplantation.Material and methods: From 2003 to 2013, 24 patients ( 8 female and 16 male), including 23 adults and one adolescent (17 years of age) underwent hepatic vein stent placement for hepatic venous outflow obstruction after orthotopic liver transplant.Pre and post stent deployment pressure gradients were measured.Results: Reduction of pressure gradient was achieved in 23 of 24 patients .Reduction of post stent placement to 3mmHg or below was achieved in 15 of 24 patients.Mean pressure gradient before stenting was 15.5 mmHg with SD of 3.5 mmHg and mean pressure gradient after stenting was 2 mmHg with SD of 2.8 mmHg with mean reduction in pressure of 13.5 mmHg with SD of 6.4 mmHg.There were no immediate major complications in our population.Mean interval from transplantation to stenting was 570 days.Mean follow-up was 618 days.Analysis of pre and post liver function values is ongoing.Conclusion: Hepatic vein stenting for the treatment of post liver transplant clinically evident hepatic venous outflow obstruction is a safe and technically successful procedure.post stent placement venogram demonstrates resolution of stricture and rapid flow