tbuckley/cabot-search huggingface dataset:
THE TRAINED NURSE AND HER POSITION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERYTHEMA MULTIFORME AND THE KIDNEYS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Durability of response with larotrectinib in adult and pediatric patients with TRK fusion cancer
Authors: D. Hyman, D.S.W. Tan, C. van Tilburg, C. Albert, B. Geoerger, A. Farago, T. Laetsch, S. Kummar, F. Doz, U. Lassen, S. Dubois, R. McDermott, L. Mascarenhas, J. Berlin, E. Rudzinski, S. Nanda, B. Childs, A. Drilon, D.S. Hong
Journal: Annals of Oncology (2019)
Seventeenth Report of the State Board of Health of Wisconsin.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The prognostic value of mid-treatment prostate-specific antigen level in patients receiving salvage radiotherapy.
Authors: Jason Homza, John T. Nawrocki, Harmar D. Brereton, Christopher A. Peters
Journal: Journal of Clinical Oncology (2019)

289 Background: Salvage radiotherapy (SRT) may be employed as a potentially curative intervention for patients experiencing biochemical failure (serum prostate-specific antigen [PSA] ≥ 0.2 ng/mL) after prostatectomy for localized prostate cancer. Patients not showing a favorable response to SRT alone may require additional therapies and may benefit from earlier identification of this need. Methods: 131 consecutive patients received SRT during the timeframe of this study. 76 were deemed eligible based on the following criteria: prostatic adenocarcinoma diagnosis receiving SRT, no clinical evidence of metastasis, no hormone use prior to/during SRT, serum PSA measurement halfway through SRT, and minimum follow-up time of 3 months. Median follow-up time was 51.6 months. Eligible patients were divided into three groups based on PSA response by the midpoint of treatment: no change, decrease, or increase in PSA. The primary endpoint of the study was clinical failure (measured from SRT completion), defined as serum PSA value ≥0.2ng/mL above the post-radiotherapy nadir, initiation of androgen deprivation therapy, development of bone metastasis, or death from prostate cancer. Results: 13.1% experienced no change in PSA halfway through SRT (group 0), 68.4% of patients experienced a decrease (group 1), 18.4% experienced an increase (group 2). Four-year freedom from clinical failure was 60.0% for group 0, 58.3% for group 1, and 41.7% for group 2. Median time to clinical failure was 71.7 months for group 1, 26.8 months for group 2, and was not reached for group 0. Pairwise multiple comparison demonstrated a significant difference in four-year freedom from clinical failure between groups 1 and 2 (p = 0.036). Conclusions: These data strongly suggest that changes in PSA are apparent midway through SRT and are associated with 4-year freedom from clinical failure. Further study is warranted to determine whether mid-treatment PSA during SRT may be used to identify a subset of patients that may benefit from treatment intensification.
Fundamental Elements of the Patient-Physician Relationship
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An outbreak of multiple-drug-resistant Salmonella enteritis from raw milk
Authors: C. O. Tacket
Journal: JAMA (1985)

In early 1983, an outbreak of illness caused by raw milk contaminated with multiple-antimicrobial-resistant<i>Salmonella typhimurium</i>occurred in Arizona. One of the cases involved a 72-year-old woman who died with<i>Salmonella</i>enteritis and sepsis that had not responded to treatment with chloramphenicol. The<i>S typhimurium</i>isolates from this patient, from other ill persons, and from raw milk were resistant to ampicillin, chloramphenicol, kanamycin sulfate, streptomycin, sulfonamide, and tetracycline. These resistances were mediated by a 105-megadalton R plasmid. During the epidemic period, 43% of the<i>S typhimurium</i>isolates submitted to the Arizona Department of Health Services were resistant to chloramphenicol, and 80% of these possessed the same plasmid resistance. Although there was evidence of spread of the<i>S typhimurium</i>in the community, there was no evidence of spread of this<i>Salmonella</i>R plasmid to the normal flora of patients or their family members a median of 14 weeks after the infection. This outbreak demonstrates the ability of drug-resistant<i>Salmonella</i>to spread from the animal to the human reservoir and, in a suitable host, produce a fatal infection. (<i>JAMA</i>1985;253:2058-2060)
Consent and prisoners.
Journal: BMJ (1986)

The need for exceptional care to ensure reality of consent when treating prisoners has been shown by a recent decision of the Court of Appeal.' Specimens of body fluid obtained without consent may be used in evidence against a prisoner.Alfred Robert Apicella was convicted at the Old Bailey charged with raping three girls and attempting to bugger two of them.Among other evidence the strongest part of the prosecution case against the defendant was medical evidence.As a result of the attacks each of the three girls had contracted an unusual strain of gonorrhoea.This indicated a common attacker, but the prosecution had to show that that attacker was the defendant, and it relied on medical evidence that was improperly obtained-though the doc- tors themselves were innocent of the impropriety.While the defendant was in prison awaiting trial the prison doctor suspected that he was suffering from gonorrhoea.With a purely therapeutic intention he called in a consultant physician.The consultant examined the defendant and took from him a sample of body fluid to aid diagnosis.The consultant believed that the defendant was consenting, but (the court found) he was submitting only because, unknown to either doctor, he had been told by a prison officer that as a prisoner he had no choice.Evidence was given at the trial of the defendant that he was suffering from the same strain of gonorrhoea as the three victims.Objection was taken to the admission of that evidence on the ground that it had been taken without consent and was the physical equivalent ofan oral confession.That objection was rejected and the defendant's subsequent appeal was dismissed.
Male, Female Types May Be Distinguished By Action of Sex Hormones on the Brain
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Official Call
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of the patient with rheumatoid arthritis refractory to standard therapy
Authors: R. L. Wilder
Journal: JAMA (1988)

<h3>SELECTED CASE</h3> AT THE age of 23 years, following a pregnancy, a woman developed severe fatigue, morning stiffness, and marked swelling and tenderness of multiple peripheral joints. On presentation to her physician, she was found to have serum rheumatoid factor in a high titer, an elevated erythrocyte sedimentation rate, and an elevated level of C-reactive protein. Roentgenographic studies revealed diffuse periarticular demineralization without bony erosions. A diagnosis of rheumatoid arthritis was made. During the next three years, the woman, in addition to undergoing physical therapy, was treated without significant or sustained improvement with several nonsteroidal anti-inflammatory drugs, hydroxychloroquine sulfate, gold salts, and penicillamine. In addition, treatment with low-dose prednisone was begun at a dosage of 5 to 10 mg orally per day. Moreover, she received many intra-articular injections of corticosteroids in many of her most troublesome joints to provide transient disease suppression in those joints. Progressive disease and disability were
X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation
Authors: Vijay G. Sankaran, Jacob C. Ulirsch, Vassili Tchaikovskii, Leif S. Ludwig, Aoi Wakabayashi, Senkottuvelan Kadirvel, R. Coleman Lindsley, Rafael Bejar, Jiahai Shi, Scott B. Lovitch, David F. Bishop, David P. Steensma
Journal: Journal of Clinical Investigation (2020)

The amino acid substitution for the ALAS2 mutation was incorrectly noted in the original article.The correct designation is ALAS2 Y365H.
An IARC Evaluation of Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzofurans as Risk Factors in Human Carcinogenesis
Authors: Douglas B. McGregor, Christiane Partensky, Julian Wilbourn, Jerry M. Rice
Journal: Environmental Health Perspectives (1998)

reevaluated polychlorinated dibenzo-p-dioxins and evaluated polychlorinated dibenzofurans as possible carcinogenic hazards to humans in February 1997, using the most recent epidemiologic data on exposed human populations, experimental carcinogenicity bioassays in laboratory animals, and supporting evidence on relevant mechanisms of carcinogenesis.2,3,7,8-Tetrachlorodibenzo-pdioxin (TCDD) was evaluated as carcinogenic to humans (IARC group 1 classification) on the basis of limited evidence of carcinogenicity to humans derived from follow-up of workers who had been heavily exposed in industrial accidents and sufficient evidence of carcinogenicity in experimental animals.The evaluation also considered the following supporting evidence: TCDD is a multisite carcinogen in experimental animals and has been shown by several lines of evidence to act through a mechanism involving the aryl hydrocarbon receptor; this receptor is highly conserved in an evolutionary sense and functions the same way in humans as in experimental animals; tissue concentrations of TCDD are similar in heavily exposed human populations in which an increased overall cancer risk was observed and in exposed rats that developed tumors in carcinogenicity tests.Other polychlorinated dibenzo-p-dioxins, the nonchlorinated dibenzo-p- dioxin, and polychlorinated dibenzofurans were evaluated as not classifiable as to their carcinogenicity to humans (group 3).
Correction: Spacer device with face mask attachment for giving bronchodilators to infants with asthma
Authors: M Youle, J Clarbour, M Connolly, C Farthing, D Hawkins, R Staughton, B Gazzard
Journal: BMJ (1989)

Mouth ulceration is common in patients infected with HIV and is mainly due to malignancy, herpes simplex virus, or fungal infection.'Some patients positive for HIV antibody have recurrent mouth ulcers that are not caused by obvious infection but are histologically similar to the giant aphthous ulcers seen in Behcet's syndrome.No prospective studies of the prevalence of such ulcers have been performed, but they are often painful and unresponsive to treatment.Thalidomide, first used as a good hypnotic and seda- Clinical and immunological details ofpatients positive for HII antibody with mouth ulceration treated with thalidomide No of OKT4 helper cells Duration of Time to Time to recurrent complete healing relapse after Case Age Before During
Expression of angiotensin II receptors in human left and right atrial tissue in atrial fibrillation with and without underlying mitral valve disease
Authors: Andreas Boldt, Ulrike Wetzel, Josef Weigl, Jens Garbade, Jörg Lauschke, Gerhard Hindricks, Hans Kottkamp, Jan Fritz Gummert, Stefan Dhein
Journal: Journal of the American College of Cardiology (2003)
Contaminants in fish.
Journal: Environmental Health Perspectives (1994)

whole looks like from a slice."Bromberg said that when the model is further advanced, it will offer his center, and others, chances to collaborate."We work to understand how human cells react to toxici- ty.That's an important piece of the picture of lung function we all are trying to reach." Contaminants in FishFrom the icy waters of Boston Harbor to the warm waves of San Diego Bay, bottom- dwelling fish suffer liver damage caused by chemical contaminants, according to researchers at the National Oceanic and Atmospheric Administration.But seafood lovers need not panic, because damaged specimens were captured primarily in urban waters where commercial fishing
Long-Term Subgroup Analyses from L-Mind, a Phase II Study of Tafasitamab (MOR208) Combined with Lenalidomide in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Authors: Kami J. Maddocks, Johannes Duell, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Marc André, Martin Dreyling, Tobias F Menne, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles
Journal: Blood (2020)
Re: Scott A. Tomlins, John R. Day, Robert J. Lonigro, et al. Urine TMPRSS2:ERG Plus PCA3 for Individualized Prostate Cancer Risk Assessment. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2015.04.039
Authors: Carsten Stephan, Henning Cammann, Klaus Jung
Journal: European Urology (2015)
Transposed Information in Figure Key
Journal: JAMA Network Open (2019)

In the Original Investigation titled "Association of Childhood Adversity With Differential Susceptibility of Transdiagnostic Psychopathology to Environmental Stress in Adulthood," 1 the colors in the figure's key indicating "0 adverse childhood experiences" and "Ն3 adverse childhood experiences" were transposed.The cyan line should have indicated "0 adverse childhood experiences" and the navy line should have indicated "Ն3 adverse childhood experiences."This article has been corrected. 1
Smoke exposure in pipe and cigar smokers. Serum thiocyanate measures
Authors: T. F. Pechacek
Journal: JAMA (1985)

Pipe or cigar smoking traditionally has been considered a less risky alternative to cigarette smoking. Some surveys and experimental studies have suggested, however, that former cigarette smokers who switch to cigars and/or pipe (CP) are more likely to inhale then CP users who never smoked cigarettes; but this relationship has not been consistently noted. To clarify smoke-exposure levels from CP smoking, smoking histories and serum thiocyanate (SCN) levels were studied in 9,106 adults aged 25 to 74 years in population-based surveys of seven upper Midwestern communities. Analyses of the 306 male CP smokers indicated a significantly higher SCN level in the ex-cigarette-smoking CP users vs the CP users who never smoked cigarettes. Serum thiocyanate levels of both CP groups were significantly higher than those of nonsmokers and lower than cigarette-only smokers. However, the number of pipe bowls or cigars smoked per day was also significantly related to SCN levels, and this could account for much of the association between SCN and previous cigarette smoking status. Individuals currently smoking four or more pipe bowls or four or more cigars per day had an elevated smoke exposure equivalent to about ten cigarettes per day, whether or not they previously smoked cigarettes. Because of these findings and because former cigarette smokers were more likely to report heavy CP usage, cigarette smokers should be advised to quit rather than to switch to a pipe or cigar. (<i>JAMA</i>1985;254:3330-3332)
In This Issue
Journal: Circulation Research (2012)

Impulse Propagation of Cardiac Monolayers (p 1556)Lee et al make monolayers of iPS-derived cardiomyocytes and monitor their electrophysiology.The derivation of human-induced pluripotent stem (iPS) cells from patients with heart disorders and the subsequent differentiation of these cells into cardiomyocytes provide an excellent renewable resource of cells for studying disease mechanisms and for testing potential therapies.To investigate disease mechanisms, researchers need accurate ways to assess the physiology, including electrophysiology, of these cells in culture.So far, such assessments have been possible in single cells or small groups of cells only.In the heart, however, cardiomyocytes beat together in unison as a syncytium.Thus, it would be desirable to study how iPSderived cardiomyocytes behave as a tissue.Lee et al now describe a method for assessing the electrophysiology of human iPS-derived cardiomyocytes grown in large monolayers.They grew the cells on elastic membranes to allow for contractions and viewed calcium waves and voltage propagation through the monolayers simultaneously-using fluorescent reporter molecules for both.Importantly, they showed that the spontaneous beating rate of the monolayers resembled that of normal resting human hearts.The new technique will be especially helpful for studying mechanisms underlying genetic cardiomyopathies and arrhythmias, say the authors.