tbuckley/cabot-search huggingface dataset:
Electrical and Mechanical Activity of Frog's Heart in Electrolyte-Free Solutions
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vessel
Authors: Rachel E. Belcher
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fortschritte und Probleme in der Therapie innerer Krankheiten.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patients with gastro-oesophageal reflux disease can benefit from intermittent treatment
Journal: BMJ (1999)

Exercise is the answer for stress incontinence Urinary incontinence is a common condition in women, causing withdrawal from physical activities and reduction in quality of life.The most common type of urinary incontinence in women is genuine stress incontinence, with pregnancy and childbirth being the main cause.On p 487 Bø et al report the results of a 6 month comparison of the three most commonly recommended conservative treatments-pelvic floor exercises, electrical stimulation, and vaginal cones-in over 100 women with stress incontinence.Pelvic floor exercises were superior to the other methods in increasing strength of the pelvic floor muscles and reducing leakage; they were also well tolerated and had no side effects.
The Tragedy of the Commons Revisited
Authors: R. Fadul
Journal: New England Journal of Medicine (2009)

Garrett Hardin's essay “The Tragedy of the Commons”1 aptly describes the current state of the U.S. health care system. Hardin tells the story of herders who make what are individually rational decisions to exploit common land by grazing as many cattle as possible, to the ultimate detriment of the land and consequently the common good. The herders are not villains; rather, they are doing what makes sense given the system in place. Analogously, many observers are currently tempted to cast certain players in the health care arena as villains, but they are merely doing what is rational given the current . . .
Medical News
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Factors Affecting Adrenocortical Hormone Function
Authors: E. Brad Thompson
Journal: Environmental Health Perspectives (1981)

This paper will briefly outline those elements which must be considered in assessing the effects of any given compound which might impinge on the actions of adrenocortical steroids. Considerations that ought to be taken into account include the following: the delivery to the affected cells of corticosteroids, the uptake of the hormone by the cells, the metabolism of the hormone by the cells, the intracellular actions of the hormone, the possible secondary interactions between cells, and multihormonal actions on the final target cell.
Single-payer plan gets cautions support
Authors: P. Cotton
Journal: JAMA (1994)

HORROR STORIES about "socialized" medicine are holding less sway as physicians weigh a single-payer health care system against the alternatives. Many physicians remain strongly opposed to a single-payer system, including the leadership of the American Medical Association. However, the AMA Board of Trustees recently met with US Rep Jim McDermott (D, Wash), sponsor of HR 1200, the leading single-payer bill in Congress. (McDermott explains that bill on pages 782-784.) Even more surprising are statements from the American College of Surgeons (ACS) that a single-payer system appears to be the best way to preserve patients' right to choose their own physicians. Testifying before the House Committee on Education and Labor, ACS board of regents chair David G. Murray, MD, said that single-payer approaches "probably provide the best assurances that patients would be able to seek care from any doctor of their choice. Moreover, single-payer approaches can probably be made more simple
Palliative Care
Authors: Michael H. Levy, Michael D. Adolph, Anthony Back, Susan Block, Shirley N. Codada, Shalini Dalal, Teresa L. Deshields, Elisabeth Dexter, Sydney M. Dy, Sara J. Knight, Sumathi Misra, Christine S. Ritchie, Todd M. Sauer, Thomas Smith, David Spiegel, Linda Sutton, Robert M. Taylor, Jennifer Temel, Jay Thomas, Roma Tickoo, Susan G. Urba, Jamie H. Von Roenn, Joseph L. Weems, Sharon M. Weinstein, Deborah A. Freedman-Cass, Mary Anne Bergman
Journal: Journal of the National Comprehensive Cancer Network (2012)

These guidelines were developed and updated by an interdisciplinary group of experts based on clinical experience and available scientific evidence. The goal of these guidelines is to help patients with cancer experience the best quality of life possible throughout the illness trajectory by providing guidance for the primary oncology team for symptom screening, assessment, palliative care interventions, reassessment, and afterdeath care. Palliative care should be initiated by the primary oncology team and augmented by collaboration with an interdisciplinary team of palliative care experts.
Acute Tissue Injury Caused by Subcutaneous Fat Biopsies Produces Endoplasmic Reticulum Stress
Authors: Guenther Boden, Matthew Silviera, Brian Smith, Peter Cheung, Carol Homko
Journal: Endocrine Reviews (2009)

Abstract Background It is not known whether acute tissue injury is associated with endoplasmic reticulum (ER) stress. Objective Our objective was to determine whether open, sc fat biopsies cause ER stress. Approach Five healthy subjects underwent three open sc fat biopsies. The first biopsy, taken from the lateral aspect of a thigh, was followed 4 h later by a second biopsy from the same incision site and a third biopsy from the contralateral leg. Expression markers of ER stress, inflammation, hypoxia, and adipokines were measured in these fat biopsies. In addition, we tested for signs of systemic ER stress and inflammation in plasma and in circulating monocytes. Results mRNA/18s ratios of IL-6, monocyte chemoattractant protein-1, CD-14, hypoxia-induced factor 1-α, the spliced form of Xbox protein-1, glucose-regulated protein 78, CEBP homologous protein, and activating factor-4 were all severalfold higher, whereas mRNA/18s ratios of adiponectin and leptin were lower in fat biopsies taken from the same site 4 h after the first biopsy but were unchanged in the second biopsy that was taken from the contralateral site. The biopsies were not associated with changes in plasma and monocyte IL-6 concentrations or in monocyte ER stress markers. Also, whole-body insulin-stimulated glucose uptake was the same in 15 subjects who had biopsies compared with 15 different subjects who did not. Conclusion Open, sc fat biopsies produced inflammation, hypoxia, ER stress, and decreased expression of adiponectin and leptin. These changes remained confined to the biopsy site for at least 4 h.
GLONOINISM.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Temporal arteritis associated with normal sedimentation rate
Authors: J. Biller
Journal: JAMA (1982)

TEMPORAL arteritis confronts the clinician with many problems, the most important of which is to make an early diagnosis. In a society whose average age is increasing, temporal arteritis probably will become increasingly frequent. It behooves us also to remember that the occult form of temporal arteritis might be more common than the classic variety.<sup>1</sup>The purpose of this report is to emphasize once again the importance of early recognition and prompt treatment<sup>2</sup>and to caution the clinician that patients younger than 50 years can have this entity. <h3>Report of a Case</h3> A 48-year-old man had recurrent amaurosis fugax of the right eye develop over a two-week period. Ten weeks before examination, central retinal artery occlusion (CRAO) of the left eye developed without evidence of retinal embolism. Massage to the globe and acetazolamide (Diamox) failed to achieve any degree of visual recovery, and he remained with visual acuity limited to
Anti-CD22 CAR Therapy Leads to ALL Remissions
Journal: Cancer Discovery (2017)

In a first-in-human trial of an anti-CD22 chimeric antigen receptor T-cell therapy in children and young adults with relapsed and refractory acute lymphocytic leukemia, researchers found that the immunotherapeutic approach was not only feasible and safe, but also effective, leading to remissions in most patients. Infusions of higher numbers of T cells correlated with improved responses.
Occupational and environmental medicine
Authors: S. Deitchman
Journal: JAMA (1994)

Specialists in occupational and environmental medicine focus on recognizing, treating, and, most important, preventing illness and injury caused by workplace and environmental hazards. Only 1501 practicing specialists are board certified in occupational medicine (Ron Cornick, MALS, oral communication, December 7, 1993). However, annually there are an estimated 6 345 700 cases of work-related illness and injury among the 90 million Americans who work in private industry, and there are no comprehensive estimates of the prevalence of environmental illness.<sup>1</sup>Patients may therefore present to physicians of any specialty. Yet, too few physicians are adequately trained to recognize these illnesses. Brancati et al<sup>2</sup>studied 94 patients admitted to the general medical wards of a university-affiliated veterans' hospital. They found that 62% of the patients had at least one probable occupational disease; of that subgroup, 68% had a history of an occupational exposure that was relevant to their disease. In contrast,
Indomethacin and the nephrotic syndrome
Authors: I. H. Shehadeh
Journal: JAMA (1979)

Treatment of membranous nephropathy and the nephrotic syndrome with 2 mg/kg/day of indomethacin resulted in prompt and sustained reduction in urinary protein excretion and the loss of edema fluid, which allowed the withdrawal of diuretic therapy and liberalization of salt intake. The reduction in proteinuria was paralleled by a decrease in urinary prostaglandin E (PGE) and F (PGF) levels. Plasma PGE and PGF levels did not change appreciably. Withdrawal of indomethacin therapy resulted in an increase in urinary protein and urinary PGE excretion. Reinstitution of therapy resulted in reductions in both values. Indomethacin may provide a useful means of reducing proteinuria and controlling edema in some patients with the nephrotic syndrome. (<i>JAMA</i>241:1264-1266, 1979)
Evidence supporting cholesterol-lowering therapy for postmenopausal women with heart disease
Authors: M. R. Goldstein
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Dr Schrott and colleagues<sup>1</sup>suggest that women with established coronary heart disease have been undertreated for elevated low-density lipoprotein cholesterol (LDLC) levels based on screening data from the Heart and Estrogen/ Progestin Replacement Study (HERS). However, evidencebased medicine suggests the women were adequately treated. At screening, nearly half of the participants of the trial were taking cholesterol-lowering medication. The suggestion that women were undertreated was based on the failure of a majority of the HERS cohort to have achieved LDL-C goals set by the National Cholesterol Education Program (NCEP) adult treatment panel in 1988<sup>2</sup>and 1993.<sup>3</sup>Those goals were derived from trials involving men and extrapolated to women. The screening for HERS ended in September 1994, before evidence-based medicine suggested that women might benefit from cholesterol lowering. The Scandinavian Simvastatin Survival Study (4S)<sup>4</sup>and the Cholesterol and Recurrent Events (CARE) trial<sup>5</sup>were
LIVERPOOL EXPERIMENT
Authors: T. Ferguson
Journal: BMJ (1960)

<h3>Introduction</h3> There are significant investments in health research capacity development in the ‘global-south’. The monetary value of contributions from institutions running these programmes is not known. <h3>Methods</h3> Using the Consortium for Advanced Research Training in Africa (CARTA) as a case study we estimate in-kind contributions made by consortium members. We measured unpaid hours of labour contributed by consortium members and converted this to full-time equivalents. We assigned a monetary value to the time contributed by staff based on salaries by seniority and region. We estimated the monetary value of the contribution made by the African institutions that hosted CARTA events by comparing the difference in cost between university-hosted events with those held in commercial venues. We calculated the foregone overhead costs associated with hosting the CARTA secretariat. We excluded many costs where data were difficult to verify. <h3>Results</h3> Annually, CARTA member institutions committed a minimum of 4.3 full-time staff equivalents that are not funded by the grants. CARTA’s annual in-kind contribution represents at least 20% of total annual donor expenditure. African institutions accounted for 82.9% of the in-kind labour contribution and 91.6% of total in-kind contribution. <h3>Conclusion</h3> The consortium’s institutions and academic and non-academic staff make significant contributions to ensure the effective implementation of donor-funded programmes. This is not unique to CARTA. These contributions are usually not counted, often not recognised at institutional level nor remunerated through grants. Knowing these costs would allow for sustainability appraisals and cost-benefit assessments. This paper offers a method of how to measure these contributions and begins a discussion around this.
The effectiveness of routine screening questions in the detection of alcoholism
Authors: M. G. Cyr
Journal: JAMA (1988)

To assess the prevalence of alcoholism in an ambulatory medical clinic and to determine the effectiveness of screening questions for alcoholism, 232 new patients in a medical primary care unit were interviewed using a questionnaire that included the Michigan Alcoholism Screening Test (MAST). Based on MAST scores, 47 of 232 subjects were designated as alcoholics, yielding a prevalence of alcoholism of 20.3%. Sensitivities and specificities for alcohol-use questions were calculated using the MAST diagnosis of alcoholism. The questions "How much do you drink?" and "How often do you drink?" yielded low sensitivities of 34.0% and 46.8%, respectively. The question "Have you ever had a drinking problem?" considered alone had a high sensitivity of 70.2%; when combined with "When was your last drink?" this question had a sensitivity of 91.5%. We recommend the routine incorporation of these last two questions into the medical history in light of the high prevalence of alcoholism in this outpatient population. (<i>JAMA</i>1988;259:51-54)
Comparative Aspects of Pesticide Metabolism in Plants and Animals
Authors: Julius J. Menn
Journal: Environmental Health Perspectives (1978)

Pesticide chemicals are an important component of modern agriculture. Through their use, plants and animals are exposed to pesticides directly and indirectly from transport through soil, water, and other environmental components. Pesticide chemicals which are absorbed by plants and animals undergo extensive biotransformation. Lipophilic compounds are converted to polar metabolites through a variety of microsomal and extramicrosomal reactions in plants and animals. Generally, biotransformations are qualitatively similar in both systems. However, there are important quantitative rate differences in metabolism which often determine the balance between activation and deactivation of a pesticide. Furthermore, there are qualitative differences in conjugative mechanisms in plants and animals. Animals through an efficient excretory system eliminate transformation products via the urine and feces. Since efficient excretory systems are absent in plants, terminal degradation products are stored as conjugates and/or derivatives which may be incorporated into the plants themselves. Metabolic transformations of selected pesticides illustrating various types of reactions in plants and animals are discussed.
Salivary and stool microbiota differences are related to differences in 90-day hospitalizations in Mexican compared to American patients with cirrhosis
Authors: Jasmohan S Bajaj, Andrew Fagan, Edith Gavis, Masoumeh Sikaroodi, Mayra Rojas Lara, Ivvone Escalona Nandez, Omar De Leon Osorio, Michael Fuchs, Patrick Gillevet, Chathur Acharya, Aldo Torre
Journal: Journal of Hepatology (2020)
Trace Nitrogenous Species in Urban Atmospheres
Authors: James N. Pitts, Arthur M. Winer, Geoffrey W. Harris, William P. L. Carter, Ernesto C. Tuazon
Journal: Environmental Health Perspectives (1983)

Recent results concerning the identification and measurement of nitrogenous air pollutants in the California South Coast Air Basin (CSCAB) are presented. In planning or evaluating studies of the human health effects of these pollutants, it is important to consider the entire range of species which may be present. We provide estimates of typical exposures to nitrogenous air pollutants during a single day oxidant event in the CSCAB.
Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice
Authors: Haiyun Ling, Tong Zhang, Laetitia Pereira, Christopher Kable Means, Hongqiang Cheng, Yusu Gu, Nancy D. Dalton, Kirk L. Peterson, Ju Chen, Donald Bers, Joan Heller Brown
Journal: Journal of Clinical Investigation (2012)