tbuckley/cabot-search huggingface dataset:
Myasthenia gravis and rheumatoid spondylitis. Coexistence in three cases
Authors: J. B. Carter
Journal: JAMA (1965)

RECENTLY, we observed a patient having myasthenia gravis and long-standing rheumatoid (ankylosing) spondylitis. The coexistence of these two relatively uncommon diseases was unusual in our experience, and a review of the English literature failed to reveal any previously reported cases. However, review of the case histories of the 857 patients having myasthenia gravis who were seen at the Mayo Clinic from 1934 to July 1964 yielded two other cases. These three cases are the subject of this report. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 55-year-old married white man, an electrician, entered the hospital on March 13, 1964, because of diplopia and ptosis of the upper eyelids. The diplopia had begun in September 1962, but it had not become severe until December 1963, when the ptosis began. Myasthenia gravis had been diagnosed, and the patient had responded well to treatment with pyridostigmine (Mestinon) bromide. However, in February 1964 his symptoms had
Mutagenesis by Metal-Induced Oxygen Radicals
Authors: Thomas M. Reid, Daniel I. Feig, Lawrence A. Loeb
Journal: Environmental Health Perspectives (1994)

To assess the contribution of reactive oxygen species (ROS) to metal-induced mutagenesis, we have determined the spectrum of mutations in the lacZax gene after exposure of Ml3mp2 DNA to Fe2+', Cu2+, and Ni2+.With iron and copper ions, mutations are clustered and are predominantly single- base substitutions.Fe, Cu, and phorbol ester-stimulated neutrophils also produced tandem double CC-4TT mutations.This mutation may provide a marker for the role of oxidative damage in carcinogenesis.Mutagenesis by Ni2+ required the complexing of the metal to a tripeptide and the addition of H202' To assess the contribution of ROS in mammalian cells, we determined the spectrum of mutations produced when purified DNA poly- merases-ca and -P synthesized DNA using a template that had been damaged by ROS.The mutation spectra produced by the two polymerases indi- cates that these enzymes substitute different nucleotides opposite the same lesions.-
European Perspectives
Journal: Circulation (2006)

C ardiology in Cyprus is undergoing significant changes as the country now produces its own cardiologists and faces the challenges of a Western lifestyle.With a population of 767 000, Cyprus has around 115 cardiologists.Of these, 12 (11.3%)are women.The slightly older generation of cardiologists in Cyprus trained abroad in England, the United States, and Greece, then returned as specialists, but for the past 8 to 10 years formal training for cardiologists has existed in Cyprus.The system is not typical of other European countries.Although there is a university in Cyprus, there is no medical school.Students from Cyprus therefore attend medical school overseas.They can then stay abroad for the examination in cardiology within the host nation, or they can return to Cyprus for cardiology training.The cardiologists who train in Cyprus are supervised by the Greek university authorities, and the final exams have to be taken in the Greek language at a Greek university.Dr Fessas says that this system is likely to change following the accession of Cyprus into the European Union (EU) in May 2004."The EU wants to harmonise training for the benefit of trainees and patients," he said.The European Diploma of Cardiology means doctors are accepted as European cardiologists through their national credentials.This system was introduced in 2001 and represents an equalising of qualifications and a common denominator in training.Dr Fessas says that having a medical school in Cyprus is important, and plans are underway for one to be established.Developing a medical school and a centre of excellence in cardiology for practice, research, and teaching is one of the profession's future great challenges."Medical schools give credit to the local and national practice of medicine," he said.
Endocrine Disorders.
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopy can be avoided in the assessment of ulcerative colitis in clinical trials
Authors: A. D. Dhanda, R. Greenwood, T. J. Creed, C. S. Probert
Journal: Gut (2011)

<h3>Introduction</h3> Several indices exist for the scoring of disease activity in the context of ulcerative colitis (UC) intervention trials. These combine clinical symptoms with laboratory parameters or endoscopic findings. Recently the emphasis has been on achievement of mucosal healing and therefore subjects enrolled in trials require multiple endoscopic procedures (usually with unsedated proctosigmoidoscopy) at different time points. The need for sigmoidoscopy can adversely effect recruitment into trials. A reliable non-invasive index which is a surrogate marker for mucosal healing is required to improve patient acceptability in clinical trials of UC. We aimed to compare an invasive (Mayo score) and non-invasive (partial Mayo score) activity index with histological findings from a recent clinical trial. <h3>Methods</h3> 149 subjects with moderate to severe UC enrolled in a multicentre clinical trial were assessed using total and partial (excluding the endoscopic subscore) Mayo scores at day 0, week 4 and week 8. As an optional substudy, histological evaluation of biopsies was performed in 69 subjects. Using week 4 data, a model was constructed to predict total Mayo score from partial Mayo score; the model was then tested using week 8 data. A Bland and Altman test of agreement was performed. Biopsies were assessed by a single blinded independent gastrointestinal histopathologist and scored using an index described by Riley <i>et al</i>.1 The Mayo score was compared to histological score by linear regression. <h3>Results</h3> There is a weak correlation between histology score and both partial Mayo score (r=0.35) and total Mayo score (r=0.25). There is poor correlation between endoscopic subscore and histology score (r=0.10). Using the partial Mayo score (where the score equals x) and applying a formula (4/3)x + 0.2 accurately predicts the total Mayo score at week 4 (r=0.98) and week 8 (r=0.98). The change in total Mayo score from week 4 to week 8 correlated well with the change in score predicted by the model based on partial Mayo score (r=0.93). The Bland and Altman test of agreement suggests good agreement to an accuracy of ± 1 point. While very accurate for mild and moderate disease there is insufficient data to validate it in severe disease. <h3>Conclusion</h3> There is poor correlation between histology and Mayo scores. Addition of endoscopy subscore to the clinical domains of the Mayo score adds nothing. If researchers wish to measure mucosal healing then sigmoidoscopy alone is inadequate and histology is necessary until such time as non-invasive biomarkers (eg, white cell proteins) have been validated.
Pandemic alert level 6: Scientific criteria for an influenza pandemic fulfilled*
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2009)

Preview this article: Pandemic alert level 6: Scientific criteria for an influenza pandemic fulfilled*, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/14/23/art19237-en-1.gif
The Treatment of Diabetes Mellitus. With Observations Based upon Three Thousand Cases.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1157: Single-cell transcriptmoics identifies rhamm positive proliferative cells within human colorectal cancer stem cells
Authors: Michitaka Nakano, Kikushige Yoshikane, Kohta Miyawaki, Shinichi Mizuno, Kyoko Yamaguchi, Takuji Yamauchi, Hiroshi Ariyama, Hitoshi Kusaba, Masafumi Nakamura, Takahiro Maeda, Eishi Baba, Koichi Akashi
Journal: Cancer Research (2019)

Abstract Cancer stem cells (CSCs) can be prospectively isolated based on specific surface marker such as CD44, CD133, LGR5, and CD166, in human colorectal cancer. However, the employment of these CSCs' markers are still insufficient to prospectively isolate the colorectal CSCs. To overcome the cellular heterogeneity of previously reported CSCs fraction, we performed single-cell mRNA sequencing (scRNAseq) of 72 cells within organoid. By conducting scRNAseq, we identified CSCs-like sub-population with high expression of MKI67 and Cyclin families, which was generally expressed in proliferative state of the cells within the organoid. Remarkably, high expression of hyaluronan-mediated motility receptor (HMMR) encoding cell membranous and cytoplasmic molecule, receptor for hyaluronan mediated motility (RHAMM), which was reported to associate with CD44 in hyaluronan binding, was observed in the CSCs-like cells. Prospective isolation of RHAMM+ CD44+ cells, that were sub-population of conventional CSCs fraction, revealed higher organoid- and tumor-forming abilities. Furthermore, comprehensive gene expression analysis also demonstrated the proliferative gene expression within RHAMM+ CD44+ cells. Here, we report RHAMM+ proliferative cells that sub-fraction the conventional CSCs population. &amp;lt;!–EndFragment–&amp;gt; Citation Format: Michitaka Nakano, Kikushige Yoshikane, Kohta Miyawaki, Shinichi Mizuno, Kyoko Yamaguchi, Takuji Yamauchi, Hiroshi Ariyama, Hitoshi Kusaba, Masafumi Nakamura, Takahiro Maeda, Eishi Baba, Koichi Akashi. Single-cell transcriptmoics identifies rhamm positive proliferative cells within human colorectal cancer stem cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1157.
CORRECTION
Authors: G Lippi, C Mattiuzzi, J Baker
Journal: British Journal of Sports Medicine (2004)

If you have a burning desire to respond to a paper published in BJSM, why not make use of our ''rapid response'' option?Log onto our website (www.bjsportmed.com), find the paper that interests you, and send your response via email by clicking on the ''eLetters'' option in the box at the top right hand corner.Providing it isn't libellous or obscene, it will be posted within seven days.You can retrieve it by clicking on ''read eLetters'' on our homepage. Mandatory wearing of helmets for elite cyclists: new perspectives in prevention of head injuriesCycling related injuries, especially those to the head, are common causes of morbidity, death, and disability and could largely be prevented by the proper use of hard shell helmets. 1 2 Unfortunately, obvious evidence is often not acknowledged, and the use of such a valuable preventive measure has been too long ignored.Media coverage of elite competitions, showing most athletes racing without helmets, has unfavourably influenced amateur and young cyclists for a long time.However, owing to the progressive increase in severe and fatal injuries, especially involving elite cyclists, and the evidence that the outcome of most of these tragedies might have been prevented, 1 2 the International Cycling Union announced that, from 5 May 2003, it is mandatory to wear a hard shell helmet in elite men's events for classes 4 and above.This decision was taken in agreement with the Professional Riders Association, who supported the initiative despite some internal differences of opinion.Images transmitted world wide during the 2003 Tour de France, a sporting event second in popularity only to the Olympics, are encouraging, showing all athletes wearing helmets throughout most of the race.This is a valuable message for both amateur cyclists and adolescents, as awareness is often more productive than restrictive measures.In addition, individual persuasion to wear helmets does not have the side effect of reducing the incentive to do cycling.Less cycling, in reaction to restrictive legislation, may counterbalance the beneficial effects on head injury prevention, as regular recreational aerobic activity, such as cycling, has manifest benefits on health, preventing the development of chronic disorders, including atherosclerosis, diabetes, osteoporosis, obesity, depression, and cancer.
A UNITED PROFESSION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERRATUM
Authors: Victor Zota, Patricia Miron, Bruce Woda, Azra Raza, Sa Wang
Journal: Journal of Clinical Oncology (2008)

contained errors in the last two columns of Table 1.The columns were labeled as FOLFOX-4 ϩ Placebo and FOLFOX-4 ϩ Bevacizumab, whereas they should have been labeled as XELOX ؉ Placebo and XELOX ؉ Bevacizumab, respectively.The no. of patients was given as 351 and 349, whereas it should have been 350 in both columns.The median age was given as 60, whereas it should have been 61 in both columns.The age range was given as 26-83 and 19-82, whereas it should have been 18-83 and 18-86, respectively.The online version has been corrected in departure from the print.
‘Defect of Reason’ and Criminal Liability
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modification and Implementation of NCCN Guidelines™ on Colon Cancer in the Middle East and North Africa Region
Authors: Fikri Içli, Hakan Akbulut, Shouki Bazarbashi, Mehmet Ayhan Kuzu, Mohandas K Mallath, Kakil Ibrahim Rasul, Scott Strong, Aamir Ali Syed, Faruk Zorlu, Paul F Engstrom
Journal: Journal of the National Comprehensive Cancer Network (2010)

Colorectal cancer is less common in the Middle East and South Asia than in western countries, with the rectum the most common primary site, unlike in the United States. A project was planned to address various local issues regarding the management of common cancers, including colorectal cancer, and to adapt the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) to the Middle East and North Africa (MENA) region. A survey of oncologists in this geographic area showed that the management practices and issues regarding colorectal cancer are similar to those presented in the NCCN Colorectal Cancer Guidelines. However, 2 major differences exist: most oncologists in the MENA region prefer chest radiograph over CT in pretreatment workup, and almost 50% of them prefer to use cetuximab in the first-line treatment of patients with the wild-type KRAS gene. The committee, comprising 9 oncologists from different countries, proposed 4 modifications to the 2009 version of the NCCN Colorectal Cancer Guidelines for use in the MENA region, relating to 1) short-course preoperative radiotherapy, 2) dose of capecitabine, 3) stereotactic radiotherapy for liver metastasis, and 4) qualification of surgeons performing colorectal surgery. The modification of NCCN Colorectal Cancer Guidelines for use in the MENA region represents a step toward creating a uniform practice in the region based on evidence and local experience.
Steroids, San Francisco
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RESPONSE: Re: Cancer Incidence in Denmark Following Exposure to Poliovirus Vaccine Contaminated With Simian Virus 40
Authors: E. A. Engels, M. Frisch
Journal: JNCI Journal of the National Cancer Institute (2003)

Simian Virus 40We read with interest the recent article by Engels et al. (1) in which the authors performed a retrospective birthcohort analysis in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40 (SV40) to clarify whether SV40 infection increases risk of mesothelioma, choroid plexus tumors, and non-Hodgkin's lymphoma, or of cancers arising in children.The authors concluded that "exposure to SV40-contaminated poliovirus vaccine in Denmark was not associated with increased cancer incidence."
THE SEROLOGIC GROUPING OF HEMOLYTIC STREPTOCOCCI
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal