tbuckley/cabot-search huggingface dataset:
QOLP-19. EFFECT OF INTENSIVE NUTRITION INTERVENTION ON PEDIATRIC PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMORS WITH CONCURRENT RADIOCHEMOTHERAPY
Authors: Lin Bo Cai, Yangqiong Zhang
Journal: Neuro-Oncology (2018)

Pediatric patients with central nervous system (CNS) tumors undergoing chemoradiotherapy are at high risk of malnutrition. The goal of this study was to investigate the effects of intensive nutrition intervention on the pediatric patients with CNS tumors receiving concurrent chemoradiotherapy. We analysed retrospectively the clinical outcomes of 28 CNS tumor patients who were received early nutritional intervention (nutrition intervention group, NG) before they were treated with chemoradiotherapy. The outcomes of these patients were compared to that of 39 patients who received chemoradiotherapy without any early nutritional intervention (control group, CG). There are no significant differences between two groups in hemoglobin, platelet, prealbumin, globulin, and albumin before they were treated with chemoradiotherapy. However, the white cell count in control group was larger than that in NG (6.07 ± 1.35 vs. 8.87 ± 5.10p<0.05) (109/L). There are no significant differences between two groups in prealbumin, globulin and albumin after they were treated with chemoradiotherapy. The body mass percentage (5.08 ± 10.67 % vs. -0.49 ± 5.41%), white cell count (2.86 ± 1.00 vs. 2.31 ± 0.76) (109/L), hemoglobin count (120.20 ± 39.701 vs. 100.62 ± 14.44) (109/L) and platelet count (141.36 ± 47.95 vs. 101.11 ± 27.00 (109/L) in NG were higher than that in CG after they were treated with chemoradiotherapy. And the radiotherapy interruption time0.35 ± 1.20 vs. 2.07 ± 2.98 daysin NG were shorter than that in CG after they were treated with chemoradiotherapy. Early nutrition intervention can effectively improve the nutritional status of pediatric patients when they were treated with chemoradiotherapy. These results suggested that nutritional intervention must be initiated before chemoradiotherapy.
A phase I/II study of ipilimumab in women with metastatic or recurrent cervical carcinoma: A study of the Princess Margaret and Chicago N01 Consortia.
Authors: Stephanie Lheureux, Marcus O. Butler, Blaise Clarke, Mihaela C. Cristea, Lainie P. Martin, Katia Sonia Tonkin, Gini F. Fleming, Anna Tinker, Hal W. Hirte, Daliah Tsoref, Helen Mackay, Neesha C. Dhani, Prafull Ghatage, Nhu-An Pham, Vinicius Motta, Lisa Wang, Katherine Karakasis, Smitha Udagani, Howard Streicher, Amit M. Oza
Journal: Journal of Clinical Oncology (2015)

3061 Background: Response to second-line therapy in cervical cancer (CC) is infrequent. Based on evidence of HPV-induced immune evasion, immunotherapy is an attractive strategy in CC. Ipilimumab (Ipi) is a fully humanized monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4, a molecule that acts to downregulate the T cell immune response. Methods: A multicenter trial was designed to evaluate Ipi IV in metastatic/recurrent cervical cancer (NCT01693783). Eligibility requirements included measurable disease progression and prior exposure to platinum therapy. A run-in phase I safety cohort was scheduled using Ipi 3mg/kg every 21 days for four cycles in 6 patients (pts). The phase II was planned in 32 pts with Ipi 10mg/kg every 21 days for four cycles; followed by four cycles of maintenance therapy (same dose) every 12 weeks for pts demonstrating radiologic response/stabilization. Primary objectives were safety and response rate at the end of cycle 4. Immune correlative studies were performed on peripheral blood pre- and post-Ipi therapy, on archival tissue, on fresh tumor obtained prior to registration and 7 days post cycle 2. Results: From Dec/12 to Sept/14, a total of 42 pts with a median age of 49 (23-78) were enrolled; 29 pts had squamous CC and 13 pts had adenocarcinoma. Thirty five pts had prior radiation completed > 3 months prior to enrollment and 21 pts had received 2/3 prior regimens. Toxicities were manageable and Grade 3 toxicities included diarrhea (4 pts) and colitis (3 pts). Best response (RECIST 1.1) for the 34 evaluable pts (2 pts awaiting results) included: 3 PR (1 PR and 2 uPR), 8 SD and 23 PD. The median PFS was 2.5 months (95% CI: 2.3-3.2). HPV testing was positive in 33 tumors. Intratumoral CD3, CD4, CD8, FoxP3, IDO and PD-L1 expression pre and post treatment are pending. Multicolor flow cytometry on peripheral lymphocytes revealed a treatment dependent increase of ICOS, HLA-DR, CCR4, and PD-1 during initial treatment which returned to baseline during maintenance. Conclusions: Ipi was well tolerated in cervical cancer pts. There is a signal of activity of immunotherapy in cervical cancer. Following Ipi treatment, an immune activation has been observed. Clinical trial information: NCT01693783.
Cardiac arrest related to anesthesia. Contributing factors in infants and children
Authors: M. R. Salem
Journal: JAMA (1975)

A collaborative retrospective study undertaken to investigate cardiac arrest related to pediatric anesthesia in seven institutions between 1960 and 1972 showed 73 instances in which anesthesia was thought to have been either directly responsible or had played an important contributing role. About two thirds of these patients were successfully resuscitated. Cases were found to fit into one of two major categories: cardiovascular and respiratory. Among cardiovascular factors, blood loss, preoperative anemia, inappropriate administration of succinylcholine, and accidental administration of potassium were important contributing causes. Respiratory factors included failure to maintain a patent airway and ventilatory problems. In retrospect, most of these accidents were preventable. Such information should indicate where research emphasis needs to be placed and that our current methods of teaching and training need to be reevaluated. (<i>JAMA</i>233:238-241, 1975)
Ambulatory care medical records. Uniform minimum basic data set
Authors: C. B. Jackson
Journal: JAMA (1975)

System, or as I shall term it, the virtue of method, is the harness without which only the horses of genius travel. Sir William Osler<sup>1</sup> IN AUGUST 1974, a group of consultants to the US National Committee on Vital and Health Statistics set forth and defined a minimum set of items that should be entered uniformly in ambulatory medical care records.<sup>2</sup>Their purposes included improvement of medical care regardless of the setting in which it was provided and reduction of the present burden on physicians with respect to redundant recording and reporting of data from their records. Comparability in recording and definition has become much more important than in the past.<sup>3</sup>Fewer physicians are practicing alone. This increases the need for complete records comprehensible to colleagues. Second, physicians are being held more accountable since an increasing part of medical care cost is being paid by insurers (private
Council on Pharmacy and Chemistry
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Further Investigation into the So-Called Hendon Cow Disease, and its Relation to Scarlet Fever in Man
Authors: E. Crookshank
Journal: BMJ (1888)

meeting of the Clinical Society.In this paper the author demon.strates by instances how portions of the prostate might be removed by scissors through a suprapubic incision.I am disposed to think that this, on still fiirther trial, will be found the best way to deal with such cases, for it places the operator in view of those projecting nmasses of degenerated prostate tissue which invariably protrude towards the cavity of the bladder, and which really are the cause of the distressing symptoms of irritation which accompany them.Care, however, will be necessary, as I have just urged, in the selection of cases for operations of this kind, it being distinctly unaerstood that they are undertaken, not because the prostate is large, but because it has induced symptoms wlhich cannot be alleviated in any other way.You may remove the prostate ontirely, but this necessarily renders tIhe iudiividual incontinent for life.Lobulated masses proceeding from an liypertrophied prostate and isolnted fibromas in the part, may thus be dealt with with permanent advantage; but this is a very different thinc, to extirpating the prostate in its entirety, or seriously mutilating the muscular ring, which under all circuimstances is essential to the integrity of the bladder as a urine holder.The following instance, which I will briefly relate, substantiates the proposition with which I opened this lecture ; and, as it similarly bears uponi the operative point now under consideration, I may con- sistently close my remarks with it.In August, 1882, a patient, aged 64, came under my care with symptoms of primary carcinoma of the prostate, which caused bleed- ing, conitinuous pain, and irritability of the bladder.As no treat- ment afforded relief, I did a free median cystotomy, and proceeded with my finger and a blunt gouge to enucleato the prostate and the growth connected with it.In this I succeeded, with the exception of a small portion in front, which I could not get away.There was very little bleeding, and the patient made a good recovery, though he lost power of retaining his urine.Some degree of retentiv power evontually returned, but it became necessary to provide him with an appaTatus for controlling the incontinent escape of urine from the bladler.Ho lived for fourteen months after the operation, and was able to return to his work as a stevedore.He eventnally died from a recurrence of the disease in the glands of the groin.I showed the specimen of what was removed at a meeting of the Royal MIedical and Chirurgical Society, in connection with a discussion bearing upon the subject.
Commentaire de travail de B. J. Elmunzer et al., pp. 931
Journal: Endoscopy (2008)

See also: Endoscopic full-thickness resection of gastric tumors using a novel grasp-and-snare technique: feasibility in ex vivo and in vivo porcine modelsEndoscopy 2008; 40(11): 931-935DOI: 10.1055/s-2008-1077587
Helen Keller
Authors: Joseph Hunt
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I wish to thank and commend you for the editorial on the miracle of Helen Keller (<b>205</b>: 584, 1968). How right you are in saying that prognosis and rehabilitation take on a new dimension in the light of her achievement! Her accomplishments with the help of a skilled and constant companion represent the best in rehabilitation: She developed and used other capacities and spiritual strengths to compensate for the absence of the usual senses employed in communication. It is such glorious personal triumphs, exemplified by Miss Keller's life, which impel us in the rehabilitation effort to urge upon practitioners in all professions greater and earlier attention to the rehabilitation potential of all patients with whom they deal. Few should be judged infeasible for some progress toward independence. I know that you join with us in reminding all personnel serving patients to begin the rehabilitation process even as
Temperature; its measurement and control in science and industry. Vol. 3. Charles M. Herzfeld, editor-in-chief. Part 3: Biology and medicine.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Febrile Convulsions
Authors: C. Keith Whittaker
Journal: JAMA (1968)

An estimated one-half million US children under 5 years of age suffer febrile convulsions. Dr. Millichap's book, compact and practical, serves well these children, their parents, and their doctors. He compares critically the literature with a personal series of children having febrile convulsions and gives a thorough up-to-date discussion of the clinical manifestations, EEG, etiology, prognosis, and treatment. Factual where facts are demanded, reasoned where logic is necessary, this book is a fine example of how to write. The bold face headings help the reader immensely. This little book is a gem. Febrile convulsion, which means a convulsion with a fever not due to an infection in the brain, occurs almost exclusively between the age of 6 months and 5 years, more commonly in boys. Acute infection in the upper respiratory tract accounts for 60% to 70% of the attacks. After ten days, only about 25% of the EEGs in
An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy
Authors: J. F. Burris
Journal: JAMA (1990)

This multicenter, factorial-design trial assessed the safety and additive antihypertensive efficacy of a slow-release (SR) formulation of diltiazem hydrochloride given alone or in combination with hydrochlorothiazide for treatment of mild to moderate hypertension. After a 4- to 6-week placebo run-in period, 297 qualifying patients were randomized to receive placebo, 1 of 4 doses of diltiazem SR monotherapy, 1 of 3 doses of hydrochlorothiazide monotherapy, or 1 of 12 possible combinations of diltiazem SR and hydrochlorothiazide for 6 weeks. A dose-related reduction in blood pressure was demonstrated for each drug as monotherapy and for the two drugs in combination. Absolute blood pressures of patients who received combination therapy were lower by an overall mean of 3.0 mm Hg diastolic and 8.0 mm Hg systolic vs diltiazem SR used alone and 3.5 mm Hg diastolic and 4.0 mm Hg systolic vs hydrochlorothiazide used alone. At the largest doses used, 50% of patients achieved goal blood pressure while taking hydrochlorothiazide, 57% while taking diltiazem SR, and 75% while taking combination therapy. Combination therapy was well tolerated. This trial clearly demonstrates that diltiazem SR and hydrochlorothiazide have additive antihypertensive effects. (<i>JAMA</i>. 1990;263:1507-1512)
Transmission and severity of measles acquired in medical settings
Authors: G. Foulon
Journal: JAMA (1986)

<h3>In Reply.—</h3> Dr Foulon and colleagues have made the important observation that persons who acquire measles in the hospital are more likely to develop serious complications of the disease than those who acquire measles in other settings. We have previously advised that transmission of measles in medical settings is of particular concern because of possible spread to those with a higher risk of complications.<sup>1</sup>The age groups that, according to our data, are more likely to acquire measles in medical settings—infants and young adults—are also the age groups at higher risk of complications.<sup>2</sup>In addition, those acquiring measles in medical facilities may be at greater risk of complications because of other, underlying illnesses. Data on complications among all 241 medical setting cases included in our report are not available. However, such data are available for an outbreak in 1983 in Kern County, California, in which transmission in medical
Essential hypertension in childhood
Authors: L. C. Aschinberg
Journal: JAMA (1977)

Fifteen patients, aged 8 to 17 years, were found to have hypertension and were studied from February 1974 to December 1975. Hypertension was defined as supine diastolic blood pressure repeatedly above 90 mm Hg. Five patients had a family history of hypertension. Extensive diagnostic evaluation performed in all cases failed to show an underlying cause for the hypertension. Patients with target-organ involvement were treated with hydrochlorothiazide; five of them are currently normotensive. Of the remaining nine untreated patients, four became spontaneously normotensive within eight to 14 months of the initial evaluation. These results suggest that extensive studies in children with hypertension may not be necessary in every case if clinical findings meet the critiera for the diagnosis of essential hypertension. These studies might be desirable, however, if target-organ involvement is present. (<i>JAMA</i>238:322-324, 1977)
Ileal resection and bile salt metabolism
Authors: David Alpers, Stanford Wessler, Louis V. Avioli
Journal: JAMA (1971)

Dr. Kent Kreisman, Senior Assistant Resident, Jewish Hospital of St. Louis and Assistant in Medicine, Washington University School of Medicine: A 34-year-old woman was admitted for evaluation of diarrhea. This symptom first began in 1956, and consisted of four to five loose, watery, and occasionally bloody stools daily. The patient continued to have intermittent episodes of diarrhea over the subsequent four years, and in 1960, a diagnosis of ulcerative colitis was made. In 1964, the patient was admitted to another hospital and the terminal 4 feet of ileum, ascending colon, and half of the transverse colon were resected. The remaining distal portion of the ileum was anastomosed to the distal transverse colon. Numerous fistulae were found at the time of surgery and a diagnosis of "regional enteritis" was made. Following surgery, her weight, which had been 45.4 kg (100 lb), fell to 22.7 kg (50 lb). It subsequently returned to
Open fracture of the olecranon
Authors: O. E. Aufranc
Journal: JAMA (1967)

Dr. Richard McCollum: The patient is a 43-year-old civil service employee who sustained an injury to his left elbow. He was driving an automobile with his left elbow projecting out of the window when he passed too close to a metal roadside standard. A U-shaped laceration over the proximal part of the ulna was noted, with bone fragments protruding through the wound. The patient received emergency care at a nearby first-aid station, where a sterile bandage and posteriorly placed splint were applied and a tetanus toxoid booster and penicillin G (1 million units) were administered intramuscularly. He was then taken to the emergency ward of the Massachusetts General Hospital where results from the physical examination were normal, except for the previously noted 8 cm laceration and inability of the patient to actively extend the left elbow. Roentgenologic studies revealed an open fracture of the olecranon with displacement of the proximal
PHYSICAL FITNESS FROM TWO TO TWENTY
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Instructions for Authors
Journal: Diabetes Care (1993)

Diabetes Care publishes original articles of and commentaries about human and clinical research intended to increase knowledge, stimulate research, and promote better management of people with diabetes mellitus.Emphasis is on human studies reporting on the pathophysiology and treatment of diabetes and its complications; genetics; epidemiology; psychosocial adaptation; education; nutrition; medical economics; and the development, validation, and application of accepted and new therapies.Topics covered are of interest to clinically oriented physicians, researchers, epidemiologists, psychologists, diabetes educators, and other health-care professionals
BATTERED CHILD LEGISLATION
Authors: Office of the General Counsel
Journal: JAMA (1964)

The plight of the battered child is widely recognized, but little has been done to correct his deplorable situation (p 358, this issue). Healing the wounds or correcting a critical malnutrition is an anticlimax. Most important is rehabilitation of the environment that permits the abuse. Ideally, we strive for a society in which child abuse is nonexistent. Practically, we must prevent repeated abuse to the child or subsequent abuse to his brothers or sisters. Child abuse is insidious. Only the more flagrant cases come to public attention. Many instances do not come to the attention of physicians, and in those that do, it is often discovered that the child had suffered previously from maltreatment or injury by his parents or guardian. Sometimes the fear arises that the child may be healed only to be subjected to injury again. The current approach to the problem embraces little more than a recommendation