tbuckley/cabot-search huggingface dataset:
Integrative Medicine
Authors: K. Gundling
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Measurement Error on the Dose-Response Curve
Authors: Isao Yoshimura
Journal: Environmental Health Perspectives (1990)

In epidemiological studies for an environmental risk assessment, doses are often observed with errors. However, they have received little attention in data analysis. This paper studies the effect of measurement errors on the observed dose-response curve. Under the assumptions of the monotone likelihood ratio on errors and a monotone increasing dose-response curve, it is verified that the slope of the observed dose-response curve is likely to be gentler than the true one. The observed variance of responses are not so homogeneous as to be expected under models without errors. The estimation of parameters in a hockey-stick type dose-response curve with a threshold is considered on line of the maximum likelihood method for a functional relationship model. Numerical examples adaptable to the data in a 1986 study of the effect of air pollution that was conducted in Japan are also presented. The proposed model is proved to be suitable to the data in the example cited in this paper.
Abstract P321: Is Amyloid Deposition in the Brain of Non-demented Older Adults a Consequence of High Blood Pressure and Arterial Stiffness?
Authors: Timothy M Hughes, Lewis H Kuller, Emma J Barinas-Mitchell, Rachel H Mackey, Eric M McDade, William E Klunk, Chester A Mathis, Steven T DeKosky, Oscar L Lopez
Journal: Circulation (2013)

Background: Advances in positron emission tomography imaging using amyloid specific ligands (e.g. PiB-PET) provide in vivo measurement of amyloid deposition in the brain, a hallmark of Alzheimer’s disease (AD) and dementia. Hypertension is believed to promote AD through arterial stiffening and cerebrovascular disease. We hypothesize that vascular measures are associated with amyloid in the brain. Methods: We studied 92 participants aged 83-96 in a follow-up of the Gingko Evaluation of Memory (GEM) Study with measures of: structural MRI of the brain; PiB-PET of brain amyloid deposition; resting blood pressure (BP), ankle brachial index (ABI) and mean arterial pressure (MAP); and vascular stiffness in the central (carotid-femoral ( cf PWV) and heart femoral ( hf PWV), peripheral (femoral-ankle ( fa PWV), and mixed (brachial-ankle ( ba PWV)) vascular beds, using a noninvasive and automated waveform analyzer (Colin Co., Komaki, Japan). Before study entry, all participants underwent ApoE-4 genotyping, detailed neuropsychological battery and adjudication of cognition by committee. Participants with a diagnosis of dementia were excluded from the sub-study. Results: Half (44/92) non-demented older adults in this sub-study were PiB+ for amyloid deposition in the brain. Amyloid deposition was associated with ba PWV, systolic BP and MAP. After adjustment for covariates, one standard deviation increase in ba PWV resulted in a 2-fold increase in the odds of being PiB+. ApoE-4 status was not associated with PWV. Additionally, high white matter disease burden, but not total gray matter volume, was associated with increased cf PWV (p&lt;0.01), hf PWV (p=0.03), SBP (p=0.05) and MAP (p=0.06). Conclusions: The adverse effects of hypertension and vascular stiffness on cerebral small vessel disease is one of the most important hypotheses as to the determinants of amyloid deposition and AD. This is the first report of a possible association between vascular stiffness, BP and in vivo amyloid deposition in non-demented individuals.
In This Issue
Journal: JNCI Journal of the National Cancer Institute (1998)

Glutathione S-Transferase and Breast CancerPolymorphisms in the genes encoding specific glutathione S-transferase (GST) enzymes can produce hereditary differences in enzyme activity.Losses of function or alterations in GST genes may decrease the ability to detoxify certain carcinogenic compounds or harmful chemical intermediates and, thus, may increase risk of developing cancer.In a nested case-control study, Helzlsouer et al. (p.512) describe variations in three GST genes (GSTMl, GSTTl, andGSTPl).The " .. . [I]t is biologically plausible that low-activitylevel [glutathione S-transferase] genotypes would be associated with an enhanced susceptibility to cancer."-K.J. Helzlsouer et al. (p.512) authors find that the risk of a woman developing breast cancer appears to increase as the number of putative high-risk GST variants that she carries increases.Kelsey and Wieneke point out in an editorial (p.484) that the results of Helzlsouer et al. differ from those of other studies, including the one published by Kelsey and coworkers, but are not necessarily conflicting.They point out that geographic and ethnic differences in the populations may influence the study outcomes.They propose that one may be able to assess the risk of breast cancer accurately by subclassifying breast cancer into etiologically more homogeneous groups employing highly sensitive molecular techniques.
New Truths in Ophthalmology
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-acting nitrates in the treatment of angina pectoris
Authors: N. Reichek
Journal: JAMA (1976)

"LONG-ACTING" nitrates are widely regarded as a mainstay of medical therapy for angina pectoris, but their efficacy and duration of action remain controversial. Moreover, a confusing variety of nitrate preparations is currently available (Table). Now that other effective modes of angina prophylaxis exist (for example, propranolol hydrochloride or coronary bypass surgery), a critical awareness of the usefulness and limitations of long-acting nitrates is all the more important. This review will outline nitrate pharmacology and propose a practical approach to the rational selection of an effective nitrate regimen for the individual patient. The therapeutic effectiveness of sublingual nitroglycerin in typical angina pectoris is clear-cut and undisputed. Administration of an effective dose during anginal pain clearly reduces the duration of the episode if the patient's untreated angina normally persists long enough for sublingual nitroglycerin to take effect. While this effect is helpful and reas
Retinoscopy (or Shadow-test) in the Determination of Refraction at One Meter Distance with a Plane Mirror.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Type 2 Diabetes Prevention in the “Real World”
Authors: Pilvikki Absetz, Raisa Valve, Brian Oldenburg, Heikki Heinonen, Aulikki Nissinen, Mikael Fogelholm, Vesa Ilvesmäki, Martti Talja, Antti Uutela
Journal: Diabetes Care (2007)

OBJECTIVE—“Real-world” implementation of lifestyle interventions is a challenge. The Good Ageing in Lahti Region (GOAL) Lifestyle Implementation Trial was designed for the primary health care setting, with lifestyle and risk reduction objectives derived from the major diabetes prevention efficacy trials. We report on the program's effectiveness as well as findings related to the program's reach, adoption, and implementation. RESEARCH DESIGN AND METHODS—A total of 352 middle-aged participants with elevated type 2 diabetes risk were recruited from the health care centers in Päijät-Häme Province in Finland. The intervention included six group counseling sessions, delivered by trained public health nurses. Measurement was conducted at baseline and 12 months. Clinical risk factors were measured by study nurses, and lifestyle outcomes were analyzed from self-reports. Lifestyle outcomes were compared with the outcomes achieved in relevant efficacy trials, and within-subject changes were tested for risk reduction. RESULTS—At baseline, mean BMI was &amp;gt;32 kg/m2, and 25% of the participants had impaired glucose tolerance. At 12 months, 20% of participants achieved at least four of five key lifestyle outcomes, with these results being comparable with the reference trials. However, physical activity and weight loss goals were achieved significantly less frequently (65 vs. 86% and 12 vs. 43%, respectively). Several clinical risk factors decreased, more so among men than women. CONCLUSIONS—This trial demonstrates that lifestyle counseling can be effective and is feasible in real-world settings for individuals with elevated risk of type 2 diabetes. To increase program impact, program exposure and treatment intensity need to be increased.
Endocrinology, Springfield, Ill
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HEART DISEASE AS A PUBLIC HEALTH PROBLEM
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die konservative Behandlung entzündlicher Genitalerkrankungen der Frau.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive value of microalbuminuria in longstanding insulin dependent diabetes.
Authors: K Borch-Johnsen
Journal: BMJ (1993)

Voss and colleagues are but a snapshot of a child's growth, and if the whole height velocity curve of all their short children, either with or without organic disease, was available this cyclical pattern of growth would be evident.Hence their finding that some of the short children with organic disease had a normal height velocity whereas others had a subnormal velocity is likely to be only a transient phenomenon; were they to continue their observations for longer (though previously shown in short normal children over only two years) the position of each child relative to the mean might be reversed.Indeed, it would be worrying if this was not the case.This forms the basis of a new screening method founded on both height velocity and height that we are developing (G E Butler et al, British Paediatric Association proceedings, 1992).It is premature to dismiss height velocity obtained over a single year as being a poor method of determining organic causes of short stature.Until we have a better understanding of the pattern of abnormal growth, any short children growing less than the 25th centile for height velocity or less than 4 cm a year should be referred for a specialist opinion.
Management of gout
Authors: H. F. Klinefelter
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Patients leave the hospital against medical advice for a variety of reasons.<sup>1-3</sup>The medical importance of this phenomenon has not been well studied. We have investigated patients leaving against medical advice from a county hospital, in addition to the association between signing out against medical advice and substance abuse. <h3>Methods.—</h3> We reviewed discharge dispositions and diagnoses for the period of July 1, 1977, through June 30, 1978, of medical, general surgical, and orthopedic patients at Highland General Hospital, a 300-bed county hospital in Oakland, Calif. Primary and secondary diagnoses were classified according to the<i>International Classification of Diseases of the World Health Organization</i>(revision 8). Patients were considered to be drug or alcohol abusers if they carried a diagnosis that a previous study at this hospital had shown to be associated with substance abusers in greater than 90% of cases. <h3>Results.—</h3> A total of 5,394 patients were
American Cancer Society&lt;subtitle&gt;British-American Exchange Fellowships in Cancer Research&lt;/subtitle&gt;
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article American Cancer Society: British-American Exchange Fellowships in Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 10, Issue 1, August 1949, Pages 221–222, https://doi.org/10.1093/jnci/10.1.221 Published: 01 August 1949
Imported Cases, Vaccine Exemptions Threaten US Measles Elimination
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular Disease
Authors: Joel M. Gore
Journal: JAMA (1993)

Major advances in the treatment of cardiac diseases continue at a rapid rate. Clinicians caring for patients with heart disease are bombarded with new and often differing treatment options. Intravenous thrombolytic therapy has led to a dramatic improvement in the outlook for patients with acute myocardial infarction (MI). However, reocclusion of the infarct-related artery occurs in some patients, leading to increased morbidity and mortality. Early trials of routine angioplasty immediately following thrombolytic therapy failed to show benefit compared with a more conservative approach in which angioplasty was only performed as clinically indicated. Three studies published at the same time in the same journal<sup>1-3</sup>have pointed the pendulum back toward immediate angioplasty. In these prospective randomized trials, subjects with evolving acute MI either underwent immediate percutaneous transluminal coronary angioplasty (PTCA) or received intravenous thrombolytic therapy within 12 to 24 hours of onset of chest pain, followed by 2 to 5
Mechanisms of and Facility Types Involved in Hazardous Materials Incidents
Authors: Stephen N. Kales, Gerry N. Polyhronopoulos, Michael J. Castro, Rose H. Goldman, David C. Christiani
Journal: Environmental Health Perspectives (1997)

The purpose of this study was to systematically investigate hazardous materials (hazmat) releases and determine the mechanisms of these accidents, and the industries/activities and chemicals involved. We analyzed responses by Massachusetts' six district hazmat teams from their inception through May 1996. Information from incident reports was extracted onto standard coding sheets. The majority of hazardous materials incidents were caused by spills, leaks, or escapes of hazardous materials (76%) and occurred at fixed facilities (80%). Transportation-related accidents accounted for 20% of incidents. Eleven percent of hazardous materials incidents were at schools or health care facilities. Petroleum-derived fuels were involved in over half of transportation-related accidents, and these accounted for the majority of petroleum fuel releases. Chlorine derivatives were involved in 18% of all accidents and were associated with a wide variety of facility types and activities. In conclusion, systematic study of hazardous materials incidents allows the identification of preventable causes of these incidents.
Reported Experiences with Dextran in Communist Countries
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal