tbuckley/cabot-search huggingface dataset:
Benztropine toxicity and atropine psychosis
Authors: M. R. Weinstein
Journal: JAMA (1972)

<h3>To the Editor.—</h3> El-Yousef, Janowsky, Davis, and Sekerke (220:125, 1972) point out that antiparkinsonian drugs combined with "high doses of phenothiazines" can superimpose an atropine psychosis on the underlying psychiatric illness. We can confirm this from our own extensive experience with the combined use of both categories of drugs in psychotic patients. The three case vignettes presented by El-Yousef and his colleagues may be misleading because they do not illustrate the toxic effects of "high doses of phenothiazines" combined with antiparkinsonian agents, but instead show that moderate doses of phenothiazine-related compounds in association with unusually high doses of an antiparkinsonian drug can produce an atropine psychosis. Their patients were given 12 mg, 6 mg, and 8 mg/day, respectively, of benztropine mesylate to control the extrapyramidal syndromes of patients treated with phenothiazine-related drugs; such instances are rare. We estimate that fewer than 5% of our benztropine-treated patients require more than 4
Effects of drugs on the fetus
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Campaign seeks to increase US "cholesterol consciousness"
Authors: C. Marwick
Journal: JAMA (1986)

A major national campaign is being mounted to alert both the medical profession and the public to the hazards that most investigators associate with elevated cholesterol levels. As a result, more people may be seeing physicians to have their cholesterol levels checked and to seek counseling about avoiding problems associated with high cholesterol levels. A number of organizations already are considering or even undertaking professional educational programs that might help to prepare physicians to respond to these heightened public concerns about cholesterol. Most physicians are aware that, currently, those persons older than 40 years of age with serum cholesterol levels of 240 mg/dL or above are at an increased risk of coronary heart disease, while those with levels 260 mg/dL or above are at especially high risk. As in hypertension, the "borderline risk" area still is in debate. One view, that cholesterol levels should be no more than 200 mg/dL,
Failure of hepatopulmonary syndrome to resolve after liver transplantation and successful treatment with embolotherapy
Authors: J POTERUCHA
Journal: Hepatology (1995)

The hepatopulmonary syndrome is an uncommon accompaniment of chronic liver disease. The outcome of this disorder after orthotopic liver transplantation is varibable. We describe a patient with the hepatopulmonary syndrome who underwent orthotopic liver transplantation for autoimmune hepatitis. Her platypnea and orthodeoxia failed to improve postoperatively. Pulmonary angiography showed large pulmonary arteriovenous shunts that were successfully treated with coil embolotherapy. (Hepatology 1995;21:96–100).
Guanadrel. A new antihypertensive drug
Authors: M. I. Dunn
Journal: JAMA (1981)

Guanadrel sulfate, a new adrenergic neuron inhibitor similar to guanethidine sulfate, was tested on 199 outpatients by 11 investigators. The patients had mild, moderate, or severe hypertension as determined by diastolic blood pressures of 95 to 105, 106 to 114, and 115 to 120 mm Hg, respectively. Guanadrel was found to be an effective antihypertensive agent for all levels of hypertension. Since guanadrel has a short onset of action and a short offset of action, which prevents many of the side effects of guanathidine, the dosage could be adjusted rapidly and safely. At low doses side effects are infrequent. There was no organ toxicity and no CNS effect. Guanadrel should be an effective step II or step III drug for treatment of hypertension. (<i>JAMA</i>1981;245:1639-1642)
PRE-COLUMBIAN LEPROSY.
Authors: ALBERT S. ASHMEAD
Journal: JAMA (1895)

Dr. Manuel A. Muniz, of Lima, Peru, in the<i>Cronica Medica</i>of 1886, contributes an article entitled, " La Lepra en el Peru." His notes were taken from the Historical Discourse on the Foundation and Rights of the Hospital San Lazaro, Lima, by Bravo de Lagunas, published in Lima, 1761. This work is in the library of Santiago de Chile. Dr. Lagunas shows the first royal ordinance for the care of lepers and for the foundation of a hospital was made in the time of Charles III. In 1693, the alms were ordered to be used for the support of a hospital for Indians. Finally, Philip II. prescribes that such sick persons as are afflicted with contagious diseases be carried to elevated localities, from which no defiled wind having passed the hospitals, can flow down and reach the healthy population of the lowlands. Dr. Muniz mentions the first leper hospital at
Aminocaproic Acid
Authors: Frank H. Gardner
Journal: JAMA (1980)

The bleeding complications of some forms of thrombocytopenia are difficult to control. Many patients become refractory to platelet transfusions even when HLA-matched. We have successfully used aminocaproic acid to control bleeding in 13 patients with amegakaryocytic thrombocytopenia. Four patients receiving long-term therapy with this drug had striking reductions in the number of platelet transfusions required for capillary bleeding. No adverse effects have been noted save for orthostatic hypotension, which is ameliorated by a reduction in dosage. Quantitative platelet function changes have been impossible to demonstrate, but no changes were noted in four patients with normal platelet counts who were receiving high-dose aminocaproic acid for treatment of subarachnoid hemorrhage. Aminocaproic acid has proved to be a valuable agent in the management of patients with amegakaryocytic thrombocytopenia, especially in decreasing the need for platelet transfusions. (<i>JAMA</i>243:35-37, 1980)
Schweizerische Medizinische Wochenshrift, Basel
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Methods
Journal: JAMA Internal Medicine (2015)

John J. You, MD, MSc; James Downar, MDCM, MHSc; Robert A. Fowler, MDCM, MS, Epi; François Lamontagne, MD, MSc; Irene W. Y. Ma, MD, MSc; Dev Jayaraman, MD, MPH; Jennifer Kryworuchko, RN, PhD; Patricia H. Strachan, RN, PhD; Roy Ilan, MD, MSc; Aman P. Nijjar, MD, MPH; John Neary, MD; John Shik, MD, MSc; Kevin Brazil, PhD; Amen Patel, MB; Kim Wiebe, MD, MPH; Martin Albert, MD; Anita Palepu, MD, MPH; Elysée Nouvet, PhD; Amanda Roze des Ordons, MD, MMEd; Nishan Sharma, MSc, EdD; Amane Abdul-Razzak, MD, MSc; Xuran Jiang, MSc; Andrew Day, MSc; Daren K. Heyland, MD, MSc; for the Canadian Researchers at the End of Life Network (CARENET)
Folic acid deficiency: early onset of megaloblastosis
Authors: D. Steinberg
Journal: JAMA (1972)

<h3>To the Editor.—</h3> It took 133 days for a healthy young man on a folicacid-deficient diet to develop megaloblastic changes in the bone marrow.<sup>1</sup>In contrast, I would like to report two patients dependent on parenterally administered nutrition devoid of folic acid who had megaloblastic abnormalities in the marrow only 16 days and 66 days after cessation of their customary dietary intake. In both instances, there was sepsis and hepatic failure. This experience emphasizes the need for supplemental folic acid in certain clinical situations. <h3>Report of Cases.—Case 1.—</h3> A 57-year-old white woman with known gastric ulcer disease underwent a subtotal gastrectomy and gastrojejunostomy on Dec 15, 1971, because of bleeding. Prior to admission, she had consumed a normal diet. Fever, a postoperative complication, was treated with broad-spectrum antibiotics. On Dec 24, because of recurrent bleeding, the serum bilirubin level was 3.1 mg/100 ml, and when she underwent
Ethical Considerations, Confidentiality Issues, Rights of Human Subjects, and Uses of Monitoring Data in Research and Regulation
Authors: P. A. Schulte, M. Haring Sweeney
Journal: Environmental Health Perspectives (1995)

Biomarkers are potentially powerful tools for use in research and regulation.Their derivation from biologic specimens collected from human subjects does, however, present many ethical implications.Ethical issues are relevant in almost each facet of human biomarker research studies: design, identification and recruitment of subjects, handling and use of the data, and interpretation and communication of results.Researchers also face a number of dilemmas when considering the use of human biologic specimens and new biomarkers.The mere fact that such markers are the result of measurements in human specimens gives the appearance of being more accurate than traditional sources of information such as questionnaires or environmental monitoring; yet, this may not always be the case.The meaning of the results of biomarker studies may be unclear because the purpose of the study is usually for research rather than clinical purposes.There generally are no established normal ranges for biomarkers and the interpretation of findings are often difficult.Researchers may not communicate these results to subjects or consider followup action because the task may be too difficult or undefined, or the reaction of the subject cannot be anticipated.A wide range of practices in this regard exists among researchers.Many questions remain unanswered about the use of biologic specimens.These include questions of ownership and access to speci- mens.Related to this is the question of whether specimens collected for one research purpose can be used for an entirely different research pur- pose.This is still an open question.Researchers and regulators may not be aware of the potential for biomarker information to affect the lives of subjects and their families without sufficient protection of personally identifiable data and regulation of its use.It is incumbent on researchers to con- sider these human subject questions whenever they are using human specimens or biomarkers.-
Inflammatory Oncotaxis
Authors: Orlando Pelliccia
Journal: JAMA (1978)

<h3>To the Editor.—</h3> In their article describing neoplasm recurrences in new areas of inflammation after long tumor-free intervals, Der-Hagopian and associates (240:374, 1978) suggest oncotaxic substances may attract dormant tumor cells to these inflammatory sites. Recently, we were confronted with a case where tumor "recurred" in the site of a previous inflammatory process that preceded the discovery of the neoplasms by four years. <h3>Report of a Case.—</h3> The patient, at age 34 years, underwent cholecystectomy because of cholecystitis associated with multiple gallstones. At age 38 years, recurrent postprandial vomiting, abdominal distension, and pain developed. At surgery she was found to have a primary adenocarcinoma of the proximal jejunum and a serous cystadenocarcinoma of the left ovary. There was no overt evidence of metastasis. A panhysterectomy, bilateral salpingooophorectomy, and small-bowel resection were performed through a left paramedian incision. She remained asymptomatic until age 44 years, when she began to note dull,
Petit's Lumbar Hernia: Repair with Marlex Mesh
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The vascular war of 1988
Authors: L. Wexler
Journal: JAMA (1989)

VASCULAR interventionalists owe much to the pioneering work of the recently deceased radiologists Charles Dotter and Melvin Judkins, who introduced the concept of percutaneous transluminal dilation of vascular obstructions.<sup>1</sup>This concept was accepted more readily in Europe than in the United States and was significantly advanced by a young German cardiologist working in Switzerland, Andreas Gruntzig. Originally trained as an angiologist, Gruntzig studied radiology and cardiology to apply his ideas for treating vascular obstructions to the coronary arteries. He designed, developed, and tested balloon catheters for the percutaneous transluminal relief of hemodynamically significant vascular lesions, first in peripheral vessels and later in the renal and coronary arteries.<sup>2-4</sup>The restraint he practiced and the scientific integrity he preached during the introductory phases of this potentially revolutionary technique are behavior patterns that, unfortunately, did not survive as a legacy after his untimely death. His procedure of percutaneous transluminal balloon angioplasty
<i>Bidrag till Kännedom om den Progressiva Paralysins Etiologi med Särskild Hänsyn till Syfilis. Akademisik Afhandlung</i>. Af Emil Hougberg, Vndertäkare vid Lappviks Sjukhus. (Memoir on the Etiology of Progressive Paralysis, with Special Reference to Syphilis.) Heisingfors: 1892
Authors: H. M. B.
Journal: American Journal of Psychiatry (1894)
Notes and Observations on Diseases of the Heart and Lungs
Authors: T. Shapter
Journal: BMJ (1866)

IN the preceding paper, the contraction and expansion of the ventricles of the heart have been spoken of as the main agents of the circulation of the blood.It is now proposed to consider the rationale of the sounds which result from this vital process thus produced.It is generally admitted, in accordance with the statement of Dr. C. J. B. Williams, that the series of phenomena which are associated with each complete movement of the heart (as the impulse, sounds, pause, etc.) occupy a cycle of time, divisible into five periods; two of these being occupied by the im- pulse, together with the first or systolic sound, which is dull and prolonged, the " rub"; one by the diastolic or second sound, sharp, short and ablrupt, the "dub"; and the remaining two by the pause.Some modern observers, however, speak of a third sound, the presystolic (Vesal, Spring) occupying the latter half of the pause; but looking to practical re- sults, any consideration of this latter need not de- tain us.Though the above division of the heart's action into five periods be adopted, as most consonant with general observation, yet, doubtless, very many hearts that one examines will warrant a division of the cycle of events into four periods only, in which case the pause is diminished by one half: the first sound occupying two periods, the second sound one period, and the pause one period.The first and second sounds are now generally, if not universally, admitted to be synchronous with the closure of the valves; the first or systolic sound with
When Doctors Get Sick
Authors: Howard M. Spiro
Journal: Annals of Internal Medicine (1998)

Letters15 September 1998When Doctors Get SickHoward M. Spiro, MD and Harvey N. Mandell, MDHoward M. Spiro, MDYale University School of Medicine; New Haven, CT 06520Search for more papers by this author and Harvey N. Mandell, MDYale University School of Medicine; New Haven, CT 06520Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-6-199809150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Winograd's graceful comments confirm our thesis: that physicians should write much more about their own experiences as patients and that other physicians should discuss them. Author, Article, and Disclosure InformationAffiliations: Yale University School of Medicine; New Haven, CT 06520 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1998Volume 129, Issue 6Page: 510 Issue Published: 15 September 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Bone Marrow Transplantation for Hodgkin's Disease and Lymphoma
Authors: J. Vose
Journal: Annual Review of Medicine (1993)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Errors in Table.
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetes, New York
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oregon Health Decisions
Authors: Ralph Crawshaw
Journal: JAMA (1985)

Oregon Health Decisions is a citizen-based project intended to develop statewide awareness of severe bioethical dilemmas. The project has set in motion civic means for addressing and resolving problems in Oregon's health provision system associated with personal autonomy, equity of access, prevention of illness, and humane cost containment. The process of civic involvement with consequent results is described together with the implications for future health policy in Oregon and elsewhere. (<i>JAMA</i>1985;254:3213-3216)
Transverse Presentation Caused by Omphalocele
Authors: Ronald J. Bolognese
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Transverse presentation, which occurs in approximately 0.25% of all deliveries, is<sup>1</sup>ten times more frequent in women with a parity of four or more than in primigravidas because of the more relaxed abdominal wall in the former.<sup>2</sup>In nulliparous patients, it is usually associated with pelvic contraction, placenta previa, malformation of the uterus, and hydrocephalus. The following is our experience with a transverse presentation in a primigravida caused by a complete omphalocele. <h3>Report of a Case:—</h3> A 22-year-old, gravida 1 para 0, white woman was seen in the prenatal clinic at six weeks gestation. The antepartum course was unremarkable until the 32nd week, when a transverse lie of the fetus was observed and confirmed by x-ray film examination. The transverse presentation persisted until the 39th week, when spontaneous labor began, at which time the presentation was again radiologically confirmed. Delivery was effected by low segment