tbuckley/cabot-search huggingface dataset:
THE PREVENTION OF THE SPREAD OF PULMONARY TUBERCULOSIS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pions, ions, neutrons, protons 'expanding scope of radiotherapy'
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Personal prophylaxis for venereal diseases
Authors: W. W. Darrow
Journal: JAMA (1975)

VENEREAL disease (VD) prophylaxis is an old and controversial subject. Conflicting recommendations on the value of the different prophylactic techniques described in lay publications (<i>VIVA</i>, October and November, 1973) and elsewhere<sup>1</sup>must be a source of confusion to practicing physicians and the general public. This article is an attempt to clarify some of the issues. In our opinion, the controversy remains unresolved for three reasons. First, few comparative studies on prophylaxis in humans have been reported. Second, most of the reported studies have employed inadequate controls. Third, techniques that appear effective in preventing some sexually transmitted diseases may not be effective against all others. If recommendations are to be made regarding the value of any prophylactic technique, we must consider (1) the direct preventive efficacy of the product, (2) the degrees to which consumers accept the product, (3) the patterns of use by sexually active couples, and (4) the
MEGA11: Molecular Evolutionary Genetics Analysis Version 11
Authors: Koichiro Tamura, Glen Stecher, Sudhir Kumar
Journal: Molecular Biology and Evolution (2021)

The Molecular Evolutionary Genetics Analysis (MEGA) software has matured to contain a large collection of methods and tools of computational molecular evolution. Here, we describe new additions that make MEGA a more comprehensive tool for building timetrees of species, pathogens, and gene families using rapid relaxed-clock methods. Methods for estimating divergence times and confidence intervals are implemented to use probability densities for calibration constraints for node-dating and sequence sampling dates for tip-dating analyses. They are supported by new options for tagging sequences with spatiotemporal sampling information, an expanded interactive Node Calibrations Editor, and an extended Tree Explorer to display timetrees. Also added is a Bayesian method for estimating neutral evolutionary probabilities of alleles in a species using multispecies sequence alignments and a machine learning method to test for the autocorrelation of evolutionary rates in phylogenies. The computer memory requirements for the maximum likelihood analysis are reduced significantly through reprogramming, and the graphical user interface has been made more responsive and interactive for very big data sets. These enhancements will improve the user experience, quality of results, and the pace of biological discovery. Natively compiled graphical user interface and command-line versions of MEGA11 are available for Microsoft Windows, Linux, and macOS from www.megasoftware.net.
Risks for Bleeding in Patients with Pulmonary Embolism Treated with Thrombolytic Agents
Authors: William W. Merrill
Journal: Annals of Internal Medicine (1995)

Letters15 April 1995Risks for Bleeding in Patients with Pulmonary Embolism Treated with Thrombolytic AgentsWilliam W. MerrillWilliam W. MerrillSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-8-199504150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Stein and colleagues describe a noninvasive management strategy for deciding whether to give thrombolytic therapy to patients who might have acute pulmonary embolism. The authors hypothesize that physicians might hesitate to administer thrombolytic therapy because of the increased risk for bleeding in patients who have received an invasive procedure, namely, pulmonary angiography. To test this hypothesis, the authors might begin by surveying physicians who manage patients with pulmonary embolism to assess why they did not administer thrombolytic therapy. They might find that those physicians did not administer thrombolytic therapy because the indications for thrombolytic therapy are unclear. ...References1. O'Meara JJ 3d, McNutt RA, Evans AT, Moore SW, Downs SM. A decision analysis of streptokinase plus heparin as compared with heparin alone for deep-vein thrombosis. N Engl J Med. 1994; 330:1864-9. Google Scholar2. The TIMI Research Group. Immediate vs delayed catheterization and angioplasty following thrombolytic therapy for acute myocardial infarction. TIMI IIA results. JAMA. 1988; 260:2849-58. Google Scholar3. Stein PD, Alavi A, Greenspan RH, Hales CA, Saltzman HA, Vreim CE, et al. Complications and validity of pulmonary angiography in acute pulmonary embolism. Circulation. 1992; 85:462-8. Google Scholar4. Carson JL, Kelley MA, Duff A, Weg G, Fulkerson WJ, Palevsky HI, et al. The clinical course of pulmonary embolism. N Engl J Med. 1992; 326:1240-5. Google Scholar5. Becker DM, Philbrick JT, Selby JB. Inferior vena cava filters. Arch Intern Med. 1992; 152:1985-94. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1995Volume 122, Issue 8Page: 630-632KeywordsAngiographyCatheterizationDecision analysisForecastingHemorrhageInferior vena cavaMorbidityMortalityMyocardial infarctionPulmonary embolism Issue Published: 15 April 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Radiological evaluation of Pott puffy tumor
Authors: R. G. Wells
Journal: JAMA (1986)

THE POTT puffy tumor represents frontal osteomyelitis with subperiosteal (pericranial) abscess, secondary to frontal sinusitis. Sir Percival Pott, an English surgeon, recognized in 1760 that "inflammation of the dura mater and the formation of matter between it and the skull, in consequence of contusion, is generally indicated by one sign, a puffy, circumscribed indolent tumor of the scalp, and a spontaneous separation of the pericranium from the skull under such tumor."<sup>1</sup>Pott puffy tumor is one of several potential complications of infection of a frontal sinus. Although a significant decrease in the incidence of disease of the frontal sinuses has occurred since the advent of antibiotics, frontal sinusitis still occurs in clinical practice and may follow a clinical course not unlike that observed during the preantibiotic era. Cranial and intracranial extension from infection of a frontal sinus may cause osteomyelitis, cavernous sinus thrombosis, meningitis, subdural empyema, and subperiosteal, epidural,
Archives of Dermatology, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of abruptio placentae
Authors: I. M. Golditch
Journal: JAMA (1970)

Analyzing 130 cases of abruptio placentae among 26,743 deliveries (1:206), the authors conclude that effective management depends primarily on early recognition of the high-risk patient, immediate hospitalization of all women with third trimester bleeding, prompt institution of liberal whole blood replacement, and early definitive diagnosis. Except when hemorrhage can not be controlled, vaginal delivery should be expected after amniotomy and oxytocin stimulation in mild cases, or if the fetus has died in utero. In moderate and severe cases, if vaginal delivery is not imminent, the viable fetus probably will not survive unless cesarean section is performed as soon as blood replacement has been started and any existing coagulopathy has been corrected.
Declining Blood Lead Levels and Cognitive Change in Children-Reply
Authors: Holly A. Ruff
Journal: JAMA (1993)

<h3>In Reply.</h3> —We appreciate the thoughtful comments on our article in<i>JAMA</i>and agree with those who urge caution in interpreting the results. Our study was the first large-scale, systematic attempt to address the consequences of intervention with moderately lead-poisoned children; it thus represents only the first step in accumulating data relevant to the issue of reversibility. The interesting Chinese study reported by Dr Rabinowitz adds to that effort. We shared Dr Ernhart's concern about the lack of relationship between blood lead levels and CIs at the initial time point. As we noted, however, both the initial effects of low to moderate levels of lead and the reversibility of those effects are likely to be part of a cumulative process, not always evident at single time points. The analyses of change, although difficult, may be the only way to investigate such dynamic processes. Ernhart rightly underscored the failure to find
Doxazosin blocks the angiotensin II-induced smooth muscle cell DNA synthesis in the media, but not in the neointima of the rat carotid artery after balloon injury
Authors: E. M. Van Kleef, J. F.M. Smits, S. M. Schwartz, M. J.A.P. Daemen
Journal: Cardiovascular Research (1996)

Objective: Infusion of angiotensin II (AngII) during the third and fourth week after balloon injury of the left common carotid artery of the rat induces smooth muscle cell (SMC) DNA synthesis. In this study we wanted to investigate whether α1-adrenoreceptors are involved in AngII-induced SMC DNA synthesis in the neointima. Methods: Adult male Wistar Kyoto rats were subcutaneously infused for 2 weeks with AngII and the α1-adrenoreceptor antagonist doxazosin during the 3rd and the 4th week after balloon injury of the left common carotid artery. Control groups received AngII, 0.9% NaCl, AngII + 50% dimethylsulfoxide (DMSO, the solvent of doxazosin), doxazosin or 50% dimethylsulfoxide. Each rat received 5-bromo-2′-deoxyuridine in a separate osmotic minipump to label DNA-synthesizing SMC. Systolic blood pressures were measured in all groups. Results: Angiotensin II caused an increase in systolic blood pressure, whereas addition of doxazosin did not affect the increase in SBP caused by AngII. In the media of the non-injured carotid artery, AngII increased SMC DNA synthesis, as the BrdUrd labeling fraction increased from 0.2 ± 0.1% (mean ± s.e.m.) in the NaCl group towards 3.4 ± 0.6% in the AngII group. Coinfusion with doxazosin reduced the AngII-induced increase in BrdUrd labeling fraction from 3.2 ± 0.8% in the AngII + DMSO group towards 0.6 ± 0.2% in the AngII + doxazosin group. A similar effect of doxazosin was found in the media of the injured left carotid artery, in which coinfusion with doxazosin also reduced the BrdUrd labeling fraction from 2.6 ± 0.8% in the AngII + DMSO group towards 0.3 ± 0.1% in the AngII + doxazosin group. In the neointima of the injured left carotid artery, AngII increased the BrdUrd labeling fraction from 11.7 ± 1.6% in the NaCl group towards 28.0 ± 3.4% in the AngII group. Coinfusion with doxazosin did not influence the AngII-induced SMC DNA synthesis, since the BrdUrd labeling fraction in the neointima of the AngII + doxazosin group was 22.5 ± 2.9%, whereas the neointimal BrdUrd labeling fraction in the AngII + DMSO group was 22.9 ± 2.3%. Little effect was found on the medial cross-sectional area. The neointimal cross-sectional area was increased as a result of infusion of AngII (0.12 ± 0.01 mm2 vs. 0.18 ± 0.01 mm2), and coinfusion of doxazosin did not reduce the AngII-induced increase in neointimal cross-sectional area (0.18 ± 0.03 mm2). Conclusions: These data suggest that α1-adrenoreceptors are not involved in AngII-induced neointimal SMC DNA synthesis and cross-sectional area, but only play a role in the media of the carotid artery.
Photoinduced Free Radicals from Chlorpromazine and Related Phenothiazines: Relationship to Phenothiazine-Induced Photosensitization
Authors: Colin F. Chignell, Ann G. Motten, Garry R. Buettner
Journal: Environmental Health Perspectives (1985)

Chlorpromazine and several other related phenothiazines are known to cause both phototoxic and photoallergic reactions in the skin and eyes of patients receiving these drugs. While the detailed mechanisms of photosensitization are not known, it is obvious that the first step must be the absorption of light by the drug, its metabolites, or photoproducts, or possibly an induced endogenous chemical. In this review, the free-radical photochemistry of phenothiazines is described, and the evidence for the involvement of photoinduced free radicals in photosensitization is examined. Upon irradiation chlorpromazine yields a variety of free radicals including the corresponding cation radical (via photoionization), the neutral promazinyl radical and a chlorine atom (Cl.) (via homolytic cleavage), and a sulfur-centered peroxy radical. The chlorpromazine cation radical is probably responsible for some of the observed in vitro phototoxic effects of this drug. However, it seems unlikely that the cation radical is involved in phototoxicity in vivo, since photoionization only occurs when chlorpromazine is excited into the S2 level (lambda ex less than 280 nm). The promazinyl radical is a more likely candidate for the phototoxic species both in vivo and in vitro. In addition, this radical can react covalently with proteins and other macromolecules to yield antigens which could be responsible for the photoallergic response to chlorpromazine. Neither oxygen-derived radicals nor singlet oxygen (1O2*), appear to be important in chlorpromazine photosensitization. In contrast, it would seem that promazine-induced phototoxicity may result in part from the generation of superoxide (O2-.).(ABSTRACT TRUNCATED AT 250 WORDS)
Duo Programmas Voluntari de Immunisation-in-Massa con le Vaccino Oral de Sabin contra Poliomyelitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notes on the Medical Treatment of Disease for Students and Young Practitioners of Medicine.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An OUTLINE OF THE MEDICAL SERVICE OF THE THEATRE OF Operations.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Photo Filler
Authors: Vesta Richardson, Umesh Parashar
Journal: New England Journal of Medicine (2011)

notices attributable to rotavirus infection that occurred before vaccination.The sustained reduction in the rate of death from diarrhea for three seasons after the introduction of the rotavirus vaccine, with reductions progressively extending to other age groups as they become age-eligible for vaccination, provides evidence that some mortality reduction is likely attributable to vaccination.The cumulative reduction of some 2640 childhood deaths since the vaccination program was initiated in Mexico highlights the lifesaving promise of rotavirus vaccines and supports the WHO recommendation for immunization of all children worldwide against rotavirus.
Remarks on the Molecular Theory of Organisation: In Reply to Dr. Beale
Authors: J. H. Bennett
Journal: BMJ (1863)

applying the stethoscope always warm the stetho- scope before using it.I have known it of inestimable value as a toy, occupying the little patient in front, while I have been stealing a march on him in the rear and employing immediate auscultation with- out his knowledge.