tbuckley/cabot-search huggingface dataset:
Rheumatoid Arthritis
Authors: O. Savage
Journal: Annals of the Rheumatic Diseases (1958)

This book is undoubtedly a classic in the literature of the rheumatic diseases.It is based on a detailed study of 293 patients with rheumatoid arthritis, with clinical and laboratory data obtained according to a set plan, which was initiated in 1929 and which has been carried out with meticulous care.The previous literature is reviewed, pointing out that the term "rheumatoid arthritis" was introduced by Sir A. B. Garrod, and that his son, A. E. Garrod, published in 1890 a study of 500 cases, using control data, and giving figures for the frequency of a family history, the age and sex distribution, the aetiological significance of emotional disturbances and the influence of the menopause.The present study is a wider up-to-date record of the same type using modem methods of investigation.In discussing the diagnostic criteria used, the authors have covered the differential diagnosis of the disease in a comprehensive manner.They admit the difficulty in some cases of a clear-cut distinction between the later changes of rheumatoid and degenerative arthritis.The inclusion in the series of cases of ankylosing spondylitis is explained, but will be regretted in this country where it is considered to be a separate disease.The known high familial incidence of this condition undoubtedly alters the figures in this series, though the authors state that no conclusion can yet be drawn as to the relative influence of environment, contagion or heredity.Careful analyses are made of the effect of other illnesses, operations, injuries, occupation, and the menopause, and are compared with control material.The mode of onset and constitutional symptoms have been studied in detail and the results are of the greatest interest.Laboratory investigations have been extensive and the findings are most valuable.This detailed description of the disease by three dis- tinguished clinicians from the Massachusetts General Hospital, backed by statistical evidence compared with a control series, is one of the most authoritative studies yet published.We are promised a further report on the life history of the disease and possibly one on rational treatment.These will be awaited eagerly by all phy- sicians interested in rheumatoid arthritis.OSWALD
Endotoxin Shock.
Authors: W. W. Spink
Journal: Annals of Internal Medicine (1962)

s1 April 1962Endotoxin Shock.W. W. Spink, M.D., F.A.C.P.W. W. Spink, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-691_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical and experimental studies on shock due to infection with Gram-negative bacteria have been carried out by the author and several associates during the past ten years. During the decade 1950-1960 clinical studies were made on 150 patients, and during 1955 to 1960, 29 patients with shock and renal failure were evaluated. The mortality rate in the latter group was 70%. Detailed experimental studies in the dog and monkey have been concerned with the nature of the initial hemodynamic changes following injection of endotoxin, the influence of endotoxin on renal function, and an evaluation of pharmacologic agents in reversing endotoxin... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. W. Spink, M.D., F.A.C.P.Affiliations: Minneapolis, Minn. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 691-691KeywordsDeath ratesEndotoxinsGram negative bacteriaGram negative bacterial infectionsHemodynamicsRenal failureShock ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...
Sarcoma-Targeting Peptide-Decorated Polypeptide Nanogel Intracellularly Delivers Shikonin for Upregulated Osteosarcoma Necroptosis and Diminished Pulmonary Metastasis: Erratum
Authors: Suoyuan Li, Tao Zhang, Weiguo Xu, Jianxun Ding, Fei Yin, Jing Xu, Wei Sun, Hongsheng Wang, Mengxiong Sun, Zhengdong Cai, Yingqi Hua
Journal: Theranostics (2020)

[This corrects the article DOI: 10.7150/thno.18299.].
Rural health care faces reform too; providers sow seeds for better future
Authors: T. Randall
Journal: JAMA (1993)

THE VOICE of rural America, scarcely audible to organized medicine and policymakers in past decades, is demanding to be heard in the debate over health care reform in the United States. Almost one fourth of all Americans, or 55 million people, are rural residents, and during the last decade they have seen their already tenuous access to primary care services decline even further. Ten percent of all rural hospitals closed during the 1980s. Numerous disincentives have caused physicians and surgeons to leave rural practices. And many rural residents have contributed to the problem by driving past rural providers to obtain their care in urban centers. The outlook for the future is also disconcerting. In a recent survey, 23% of physicians with practices in rural communities said they were dissatisfied and plan to leave within 5 years. Many experts are predicting that these physicians will pursue practices in urban areas as
The March of Medicine
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LONDON
Journal: JAMA (1926)

<h3>The Need to Limit Our Population</h3> In the<i>Morning Post</i>, the economist Mr. Harold Cox urges the need of limiting our population, replying to a letter from a woman physician, Dr. Mary Scharlieb, who expresses fear that the English birth rate is declining too rapidly. In her judgment, it is the duty of the inhabitants of Great Britain to multiply in order to fill the waste spaces of the empire. Mr. Cox points out that she overlooks the fact that the dominions will accept only picked migrants from the mother country. Since the war, the number of migrants to the dominions has declined enormously, and is still declining. At the present moment England is overcrowded. In round figures, there are four times as many persons to the square mile in England as there are in France. Yet there are unmistakable signs that the peculiar circumstances that made England the workshop
Catamenial Pneumothorax
Authors: Glen A. Lillington
Journal: JAMA (1972)

Five cases of a bizarre syndrome of recurrent right-sided pneumothorax occurring in women only at the time of menstrual flow are compared with 15 previously reported cases. Intrathoracic endometrial implants have been demonstrated in some instances, and pelvic endometriosis probably occurs in most cases even if there is no clinical evidence of pelvic disease. Administration of ovulation-suppressing hormones usually prevents the development of catamenial pneumothoraces, but the attacks recur when the drugs are discontinued. The pathogenesis of the pneumothorax is not understood. Leakage of air from the lung due to subpleural endometrial implants seems to be the most plausible explanation. Another theory suggests that air enters the peritoneum through the genital tract during menstruation and then passes through congenital perforations in the right hemidiaphragm to result in a pneumothorax.
In Protest
Authors: Bernard J. Sussman
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Having once commented upon Dr Wiltse's scientific article on chymopapain chemonucleolysis (231:474, 1975), I would not ordinarily respond a second time. However, I consider this to be a special circumstance. Dr Wiltse has made objectionable statements about this writer (234:272-274,1975), andThe Journalhas erred in failing to edit them. Such editing, as well as a determination of the essential validity of my comments, was a matter for proper disposition by the editorial staff during the eight months within which publication of these letters was delayed, and, particularly since a full three months prior to publication, chymopapain was withdrawn from IND status in uncontrolled study by the Food and Drug Administration because preliminary double-blind controlled studies indicated chymopapain to be completely ineffective. The publication of statements as offensive as those made by Dr Wiltse is so unusual that readers must necessarily assume or suspect that they are
CCM Contributions Misnumbered
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Yerushalayim
Authors: Carol Snyder Halberstadt
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pleurectomy
Authors: J. Helwig
Journal: JAMA (1965)

Pleurectomy was used to stimulate systemic-pulmonary anastomoses as a palliative treatment for patients with cyanotic congenital heart disease with pulmonary hypertension. To our knowledge, the successful application of this principle, suggested to us by Bernice Wedum, MD, has not heretofore been reported. Patients with pulmonary hypertension associated with a right-to-left shunt within the heart have systemic hypoxia due to the combination of a decreased effective pulmonary blood flow secondary to the mechanical pulmonary-arteriolar block and the effects of the right-to-left shunt itself. As a result of pulmonary arteriolar obliterative changes, the pulmonary resistance is equal to or greater than the systemic resistance. In effect, multiple peripheral "pulmonary stenoses" exist. In 1949, Barrett and Daley<sup>1</sup>described pleurectomy as a method for increasing the pulmonary blood flow in patients with cyanotic congenital heart disease with a decreased pulmonary blood flow and<i>low</i>pulmonary-artery pressures. They demonstrated the development of large, effective
Numeric Errors in Table 1
Authors: Khagendra Dahal, Kalgi Modi
Journal: JAMA Internal Medicine (2018)

Manjula Kurella Tamura, MD, MPH; I.-Chun Thomas, MS; Maria E. Montez-Rath, PhD; Kristopher Kapphahn, MS; Manisha Desai, PhD; Randall C. Gale, DrPH; Steven M. Asch, MD, MPH
Medical Symbolism.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE FUNCTIONS OF THE GALLBLADDER AND THE BILE DUCTS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: Donald E. Riesenberg
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANOREXIA AND DIET
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cervical Cancer Linked To Early Intercourse, Promiscuity
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expectation of Life
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Diagnostic and Statistical Manual of Mental Disorders Fourth edition. 886 pp. Washington, D.C., American Psychiatric Press, 1994. $42.95. 0-89042-062-9 DSM-IV Sourcebook (Vol. 1.) Edited by Thomas A. Widiger, Allen J. Frances, Harold Alan Pincus, Michael B. First, Ruth Ross, and Wendy Davis. 768 pp. Washington, D.C., American Psychiatric Press, 1994. $112.50. 0-89042-065-3 Study Guide to DSM-IV By Michael A. Fauman. 420 pp. Washington, D.C., American Psychiatric Press, 1994. $26.95…
Authors: A. Kenneth Fuller
Journal: New England Journal of Medicine (1994)
Paracervical Block With Low Doses of Chloroprocaine
Authors: Donald W. Freeman
Journal: JAMA (1975)

Results of 261 paracervical blocks done with a dose of 12 ml of 1% chloroprocaine hydrochloride solution containing 1:200,000 epinephrine were recorded. The blocks were followed by abnormal heart rate patterns for 3 to 15 minutes in six of 104 (5.8%) of the fetuses. Excellent pain relief was obtained with 142 of 172 blocks or 83%. One fetus died owing to multiple congenital anomalies. Paracervical blocks performed as described are completely safe for the mother and do not affect Apgar scores. Potential fetal risks are acceptable when considered in light of the ease of administration and the amount of pain relief obtained. (<i>JAMA</i>231:56-57, 1975)
Resistance to Antiestrogen Arzoxifene Is Mediated by Overexpression of Cyclin D1
Authors: Wilbert Zwart, Mariska Rondaij, Kees Jalink, Z. Dave Sharp, Michael A. Mancini, Jacques Neefjes, Rob Michalides
Journal: Endocrine Reviews (2009)

ABSTRACT Resistance to tamoxifen treatment occurs in approximately 50% of the estrogen receptor (ER)α-positive breast cancer patients. Resistant patients would benefit from treatment with other available antiestrogens. Arzoxifene is an effective growth inhibitor of ERα-positive breast cancer cells, including tamoxifen-resistant tumors. In this study, we show that overexpression of a regular component of the ERα transcription factor complex, cyclin D1, which occurs in approximately 40% of breast cancer patients, renders cells resistant to a new promising antiestrogen, arzoxifene. Overexpression of cyclin D1 alters the conformation of ERα in the presence of arzoxifene. In this altered conformation, ERα still recruits RNA polymerase II to an estrogen response element-containing promoter, inducing transcription of an ERα-dependent reporter gene and of endogenous pS2, and promoting arzoxifene-stimulated growth of MCF-7 cells. Arzoxifene is then converted from an ERα antagonist into an agonist. This can be explained by a stabilization of the ERα/steroid receptor coactivator-1 complex in the presence of arzoxifene, only when cyclin D1 is overexpressed. These results indicate that subtle changes in the conformation of ERα upon binding to antiestrogen are at the basis of resistance to antiestrogens.