tbuckley/cabot-search huggingface dataset:
Venereal Disease
Authors: Frank W. Barton
Journal: JAMA (1971)

We could be facing a national tragedy; there is a substantial increase in reported cases of infectious syphilis, and gonorrhea is pandemic in the United States. This is the alarming message from public health officials and the American Social Health Association.<i>Today's VD Control Problem—1971</i>, a 58-page report published by the American Social Health Association, spells out the stark facts of the near doubling of reported cases of gonorrhea since 1965, while reported cases of infectious syphilis rose for the first time since that year. For the year ending June 30, 1970, infectious syphilis rates were 8.1% higher nationally than a year earlier, with annual increases spread over 33 states and an estimated incidence between 70,000 and 80,000 reported cases. There are 250,000 cases of all forms of syphilis estimated to be diagnosed and treated each year. At the same time, gonorrhea morbidity exceeded 573,000 reported cases, a 16% increase.
Abstract 999: Gated Micro Computed Tomography Scanning: An Emerging Tool for Longitudinal Assessment of Murine Cardiac Remodeling.
Authors: Ahmad Y Sheikh, Timothy C Doyle, Maryam K Sheikh, Feng Cao, Katherine J Ransohoff, Phillip C Yang, Robert C Robbins, Michael P Fischbein, Joseph C Wu
Journal: Circulation (2007)

Background: Recent advances in high energy X-ray source computed tomography (CT) technology have made it possible to accurately image murine cardiac structure and function. We describe the use of a gated Micro CT system to assess cardiac remodeling in a murine model of myocardial infarction (MI). Methods: Adult FVB mice (n = 10) were randomized to surgically induced MI by left coronary artery ligation or sham procedure. Dual gated cardiac and respiratory Micro CT scans were performed pre-operatively and at weeks 4, 8 and 12 post-procedure. End-diastolic and end-systolic images were acquired by gating on the ECG P-and S’-waves, respectively. Post-acquisition analysis was performed using image analysis software and the following parameters were quantified: left ventricular (LV) volume and mass, right ventricular volume and mass, right and left atrial volumes, and ventricular ejection fraction (EF). Results: Images were successfully acquired with a resolution of 100 microns allowing for identification and quantification of key cardiac structures (Fig 1A ). Following MI, animals exhibited left ventricular failure with significantly increased* end systolic and diastolic volumes by week 4. Ventricular dilation continued through week 8, plateauing by week 12. Left ventricular mass increased steadily over 12 weeks*, with a significantly decreased* LVEF of 28.0 ± .05% by week 12 (pre-MI: 66.7 ± .06%,*p &lt; 0.01). Post-MI left ventricular change is detailed in Fig 1B . Conclusions: MicroCT scanning can be successfully used to characterize murine myocardial structure and function, making it a useful tool to assess cardiac phenotypes and models of cardiovascular disease.
Suppose we died young, late in life ...?
Authors: E. L. Wynder
Journal: JAMA (1977)

A DISTINGUISHED physician recently expressed concern about the long terminal illness of one of his parents. What, our colleague queried, would happen to society if medical advances led most of us to such a demise? Aside from emotional problems affecting the family, would not such a state of sick old people undo the fiscal structure of our health care system? Yes, but is it really necessary that we must end our days old<i>and</i>sick if we alter our current health care system? This question raises one of the most important issues about the future of our society—an issue of<i>human</i>capital and resources as vital and pressing as the problems of energy and economic capital and resources. The medical profession and society's planners for the future must responsibly face the issues raised by this question, and the purpose of this note is to open such a discussion. Let us
Reply
Authors: J.C. Sterling, N. Coleman, R.J. Pye
Journal: British Journal of Dermatology (1995)

Journal Article Reply Get access J.C. Sterling, J.C. Sterling Department of Dermatology, Adenbrooke's Hospital, Cambridge CB2 2QQ, U.K. Search for other works by this author on: Oxford Academic Google Scholar N. Coleman, N. Coleman Department of Histopathology, Adenbrooke's Hospital, Cambridge CB2 2QQ, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.J. Pye R.J. Pye Department of Dermatology, Adenbrooke's Hospital, Cambridge CB2 2QQ, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 3, 1 March 1995, Page 487, https://doi.org/10.1111/j.1365-2133.1995.tb08694.x Published: 01 March 1995
How and why do we measure surgical risk?
Authors: M. Chand, T. Armstrong, G. Britton, G. F Nash
Journal: Journal of the Royal Society of Medicine (2007)

Surgical decision-making has evolved over time, and what was once an intuitive matter for surgeons has now become a multi-faceted decision with increased expectations from medical staff and patients, making the decision-making process itself often as challenging as the technical procedure.When planning the most appropriate treatment for a patient, it is important to distinguish what we aim to achieve with regards to treating the pathology from what can be realistically expected from the patient physiologically.In other words, has the patient the potential to withstand the insult of the treatment itself and what are the risks involved?By quantifying this risk and making it a key part of surgical decision-making, we can arrive at the safest modality of treatment for an individual patient.This allows realistic expectations for the patient, helping them to make an informed decision.This article aims to highlight some of the important aspects of surgical risk and the impact they have on patients.
Osler and children
Authors: J. P. McGovern
Journal: JAMA (1969)

" Dr. Osler frequently advised us to make friends of children, for, said he, 'That is the way to keep your own minds young.' " So recalls one of his staff members from Johns Hopkins days, in a personal reminiscence<sup>1</sup>that contains a revealing glimpse of Sir William Osler's unique gifts with children. If one were to define the qualities important in a pediatrician, the knack of keeping one's mind young would surely rank high on the list, along with such other essentials as love of children, the ability to inspire their trust and affection, and an understanding of children broad and deep enough to permit communication with them on their level. All of these abilities and talents resided in one man, William Osler. Almost everything written about Osler contains some reference to his lifelong love of children and his amazing empathy with them. That children reciprocated is also evident— in the
Commentary
Authors: Eduardo Guimarães Hourneaux de Moura
Journal: Endoscopy (2021)

I congratulate Dr. Manol Jovani and Dr. Mouen Khashabʼs group, for publishing these two technical variants of gastric peroral myotomy (G-POEM), in the search for a better functional result. The rationale of these technical modifications is based on amplification of the functional myotomy, giving a better clinical result. The use of scintigraphy for functional assessment of gastric emptying could help us to understand failure of the initial technique and the benefit of the proposed modifications. Defining the patient group that will benefit is the biggest challenge, given the theoretically increased risk of complications.
Resident Forum
Authors: Scott B. Kleber
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Controversy over Multiple Chemical Sensitivities
Authors: Ann McCampbell
Journal: Annals of Internal Medicine (1994)

Letters1 February 1994Controversy over Multiple Chemical SensitivitiesAnn McCampbell, MDAnn McCampbell, MD485 Hot Springs Road; Santa Barbara, CA 93108Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-3-199402010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As a physician disabled with multiple chemical sensitivity, I read with trepidation the article by Simon and colleagues [1] and the accompanying editorial [2].Although I applaud the authors for attempting to examine the role of immunologic, psychological, and neuropsychological factors in multiple chemical sensitivity, a possible conflict of interest and flaws in the study design make their lack of positive immunologic and neuropsychological findings suspect. First, the study was sponsored in part by the Boeing Company, which has a huge vested interest in disproving the existence of multiple chemical sensitivity as a “real” illness. Many former ...References1. Simon GE, Daniell W, Stockbridge H, Claypoole K, Rosenstock L. Immunologic, psychological, and neuropsychological factors in multiple chemical sensitivity: a controlled study. Ann Intern Med. 1993; 119:97-103. Google Scholar2. Terr A. Multiple chemical sensitivities. Ann Intern Med. 1993; 119: 163-4. Google Scholar3. Heuser G, Wojdani A, Heuser S. Diagnostic markers of multiple chemical sensitivity. In: National Research Council, Board on Environmental Studies and Toxicology, Multiple Chemical Sensitivities, Addendum to Biologic Markers in Immunotoxicology. Washington, DC: National Academy Press; 1992:117-38. Google Scholar4. Levin AS, Byers VS. Environmental illness: a disorder of immune regulation. In: Cullen MR; ed. Workers with multiple chemical sensitivities. State of the art reviews: Occupational Med. 1987; 2:669-81. Google Scholar5. Rea WJ, Johnson AR, Youdim S, et al. T & B lymphocyte parameters measured in chemically sensitive patients and controls. Clinical Ecology. 1986;4:11. Google Scholar Author, Article, and Disclosure InformationAffiliations: 485 Hot Springs Road; Santa Barbara, CA 93108 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1994Volume 120, Issue 3Page: 249-251KeywordsChartsChemical analysisConflicts of interestDisabilitiesMedical conditionsResearch laboratories ePublished: 15 August 2000 Issue Published: 1 February 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ROSE-COLORED CELLS THROUGH ROSE-COLORED GLASSES
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Critical care medicine
Authors: M. A. Matthay
Journal: JAMA (1991)

Considerable basic and clinical research has been devoted to understanding the natural history, pathophysiology, and pathogenesis of acute lung injury. Several neutrophil-dependent and neutrophil-independent mechanisms are probably important in mediating the initial phase of acute lung injury.<sup>1,2</sup>The injury involves the airways, the interstitium, and the pleural spaces as well as the endothelial and the epithelial barriers of the lung.<sup>1,2</sup>The original description of acute lung injury (also known as the adult respiratory distress syndrome) emphasized that it is a clinical syndrome of acute respiratory failure with bilateral roentgenographic infiltrates from both atelectasis and noncardiogenic pulmonary edema.<sup>3</sup>Although this initial description was useful, it became apparent that an expanded definition was needed to achieve better precision in identifying the mechanisms responsible for acute lung injury and to determine the prognosis for survival. An expanded definition has, therefore, been developed that includes a proposed semiquantitative scoring
Gene therapy may have future role in cancer treatment
Authors: B. Merz
Journal: JAMA (1987)

WHEN GENE THERAPY becomes clinical reality, one of its first uses may be in treating cancer patients with drug-resistant tumors. John S. Lazo, PhD, associate professor of pharmacology, Yale University School of Medicine, New Haven, Conn, told the Bristol Myers Symposium on Cancer Research that he can foresee using gene therapy to restore sensitivity to chemotherapy in resistant cells; to produce toxic chemicals in resistant tumor cells; and to make normal host cells resistant to chemotherapy so that higher doses of cytotoxic compounds can be used. The trick, of course, is to isolate the genes that can produce proteins to do these things; to get those genes into the proper cells; and to see that the genes are expressed appropriately in vivo. Researchers at several institutions have been investigating gene therapy for genetic disease, and have found that it is indeed possible to transplant a gene into a stem cell
Abstract 17126: Efficacy and Safety of Dabigatran Compared With Warfarin in Patients With Atrial Fibrillation and Normal Renal Function Over Time: Insights From the RE-LY Trial
Authors: Ziad Hijazi, Stefan H Hohnloser, Jonas Oldgren, Ulrika Andersson, Stuart J Connolly, John W Eikelboom, Michael D Ezekowitz, Paul A Reilly, Salim Yusuf, Lars Wallentin
Journal: Circulation (2015)

Background: In patients with atrial fibrillation (AF) and normal renal function it has been reported that one oral factor-Xa inhibitor is associated with decreased efficacy compared to warfarin. In the RE-LY trial of patients with AF dabigatran, with approximately 80% renal elimination, was superior to warfarin for prevention of stroke and systemic embolism (SEE) with the 150 mg dose and non-inferior with the 110 mg dose and associated with significantly less major bleeding with the 110 mg dose. This is a post hoc analysis of the efficacy and safety of dabigatran vs. warfarin treatment in patients with normal renal function during the study. Methods: In the RE-LY trial among patients who received at least one dose of study medication, 17882 had creatinine measurements available at baseline, out of which 91% also had measurements after randomization. There were a total of 382 stroke/SEE, 280 ischemic strokes, and 1018 major bleed events during median follow-up of 1.8 years. The relations between outcomes, treatment, and renal function (Cockcroft-Gault estimated glomerular filtration rate (eGFR)) during follow-up were evaluated using Cox regression including treatment, eGFR as a continuous time dependent covariate, fitted using restricted cubic splines, and interaction. Hazard ratios (95% CI) comparing treatment effects were analyzed according to eGFR level. Results: In patients with normal renal function the relative risk of stroke/SEE was consistently lower in those treated with dabigatran as compared with warfarin. The patterns were similar for major bleeding with a trend of greater relative risk reduction with dabigatran as compared to warfarin at normal renal function. Conclusions: In patients with AF and normal renal function during treatment the efficacy of dabigatran compared to warfarin was consistent with the overall result of the RELY study. Both dabigatran doses were associated with lower risk of major bleeding in patients with normal renal function.
Dermal ridges and rubella.
Journal: BMJ (1967)

arteriosclerotic old man, who was not ataxic, and whose vermis contained only a few such neural myxoedema bodies, and they point out that the bodies have not been found in the cerebellar degeneration associated with chronic alcoholism nor in that due to nutritional deficiency.Consequently, though they may be' altered corpora amylacea, or artifacts owing to
SOME ASPECTS OF DESERT CLIMATES
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RELATIONSHIPS AMONG THE STEROLS, ESTROGENIC SUBSTANCES AND CARCINOGENIC COMPOUNDS
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ocular damage due to paraquat and diquat.
Authors: J. S. Cant, D. R. Lewis
Journal: BMJ (1968)

BmnsHR 59 hospital with chest pain due to suspected myo- cardial infarction were analysed for copropor- phyrin concentration by the rapid screening method of Zielhuis,' using the Donath copro- porphyrinometer.Patients who gave a history of regular heavy alcohol consumption, or who were drunk at the time of admission, were excluded.Urinary coproporphyrin excretion in-
Effects of Simultaneous Low-Level Dietary Supplementation with Inorganic and Organic Selenium on Whole-Body, Blood, and Organ Levels of Toxic Metals in Mice
Authors: Ole Andersen, Jesper Bo Nielsen
Journal: Environmental Health Perspectives (1994)

Classical experiments have demonstrated that Se compounds protect against the toxicity of several toxic metals in acute experiments with simulta- neous parenteral administration of high doses of Se and the toxic metal.Blood and organ levels of the toxic metals were increased, conceivably due to formation of inert Se complexes.Less is known about effects of long-term Se status on the toxicokinetics of toxic metals.Possible Se interactions in toxic metal biokinetics should therefore be studied at Se levels ranging from those just sufficient to avoid Se deficiency and up to those believed to be optimum in relation to antioxidative and other beneficial effects of Se.The toxic-metal exposure levels investigated should be similar to those occuring in human populations that are not occupationally exposed.To study interactions between Se and toxic metals at ultralow exposure levels, mice were fed semisynthetic diets containing different levels of Se.The mice were given ultralow doses of metal salts either as a single oral dose by stomach tube or as prolonged exposure in the drinking water.Diets with high or normal Se levels slightly, but nonsignificantly increased the whole-body retention (WBR) of Hg++ and CH3Hg+ compared to a diet low in Se.The dietary Se level was, however, without effect on the WBR of Cd2+ and Ag2, in single-dose experiments.During prolonged exposure, the diets fortified with Se increased the WBR of Ag2+, had no effect on WBR of Hg2+, and reduced the WBR of CH3Hg+ and Cd2 .During prolonged exposure, the diets fortified with Se reduced blood Hg++ while organ levels were unaltered.Blood and organ levels of CH3Hg+ were reduced or unaltered.Diets with added Se reduced blood and organ levels of Cd++ but increased blood and organ levels of Ag++.The blood lead level was reduced by Se supplementation.These results are in contrast to those previ- ously published for Se effects on the toxicokinetics of Cd and Hg compounds.The results indicate, that Se supplementation might be beneficial in populations exposed for extended periods to increased environmental levels of certain toxic metals, e.g.,