tbuckley/cabot-search huggingface dataset:
Elective circulatory arrest during neurosurgery for basilar artery aneurysms
Authors: A. J. Gissen
Journal: JAMA (1969)

The results of surgical treatment of basilar artery aneurysms have been poor compared to those after treatment of intracranial aneurysms in other locations. In order to facilitate the neurosurgical approach to this lesion, moderate hypothermia has been combined with circulatory arrest. Arrest was induced by open-chest ventricular fibrillation in five patients. Repeated intermittent cardiac massage for one minute following three to four minutes of arrest maintained tissue nutrition while still providing the neurosurgeon with good operating conditions. Careful monitoring of the patients' vital functions together with accurate correction of the blood pH changes resulted in rapid cardiovascular recovery following anesthesia and surgery.
Unintended Consequences
Authors: Jason Ryan
Journal: Annals of Internal Medicine (2005)

Letters20 December 2005Unintended ConsequencesJason Ryan, MDJason Ryan, MDFrom Beth Israel Deaconess Medical Center, Boston, MA 02215.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-12-200512200-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I agree with Dr. Knight's assertion that the ability to triage and efficiently manage numerous patients in a short time period is an essential skill for modern physicians. He rightly points out that time pressures exist outside of residency programs and are ubiquitous in today's health care system. As I previously wrote, the time constraints on residents have many sources and were increasing even before the new work-hour rules were enforced.Nevertheless, I worry about how such onerous time pressure will affect physicians right from the starting blocks of their education. As Dr. Knight points out, physicians of ... Author, Article, and Disclosure InformationAuthors: Jason Ryan, MDAffiliations: From Beth Israel Deaconess Medical Center, Boston, MA 02215.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUnintended Consequences: The Accreditation Council for Graduate Medical Education Work-Hour Rules in Practice Jason Ryan Unintended Consequences Ellis M. Knight Unintended Consequences Steven J. Zanders Metrics 20 December 2005Volume 143, Issue 12Page: 917-918KeywordsConflicts of interestHealth careHealth care qualityResidencyTriage ePublished: 20 December 2005 Issue Published: 20 December 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SAFETY IN FLYING
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STATISTICS OF STATE BOARD EXAMINATIONS
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The United States Pharmacopeia. Its value to the professions
Authors: W. M. Heller
Journal: JAMA (1970)

The United States Pharmacopeia (USP) is 150 years old this year. Founded by physicians, the USP is now produced by a consortium of the colleges and organizations of medicine and pharmacy. The USP directs its attention only to those drugs whose utility is most fully established, and its decisions are of value to all involved in the teaching and practice of medicine. Standards of pharmaceutical quality set by USP are enforced by the Food and Drug Administration (FDA). Greater involvement by physicians is needed in setting the goals for each drug product for which special bioavailability standards are needed.
Abstract 3424: Consensus molecular subtype of triple negative breast cancer to implicate in chemotherapy response
Authors: Jihyun Kim, Doyeong Yu, Jiyoon Noh, Wooyeong Jang, Hanna Yang, Youngmee Kwon, Keun Seok Lee, Sung Hoon Sim, Sun-Young Kong, In Hae Park, Charny Park
Journal: Cancer Research (2019)

Abstract Objective: The heterogeneity of triple negative breast cancer (TNBC) confers the difficulties in chemotherapy and induces poor outcome. Subtype classification of TNBC using gene expression profile could achieve to identify molecular markers to suggest therapeutic guidance. Methods: In this study, we collected gene expression profiles of 957 TNBC patients from GEO and integrated into one meta-data using meta analysis. We identified subtypes using nonnegative matrix factorization (NMF) and explored for comprehensive characteristics of consensus molecular subtype (CMS) by investigating key pathway activity, tumor microenvironment, stemness and so on. In addition, we computed the drug response score (DRscore) from MSigDB chemical perturbation signature gene set and examined drug associations with key pathways of CMS. Drug candidates were validated from independent two data sets; our patients’ expression profile (n = 38) and biobank TNBC organoids (n=64). Results: We classified four different TNBC subtypes displaying gene expression patterns including mesenchymal-like (MSL), luminal-AR (LAR), immunomodulatory (IM), and stem-like (SL). MSL were activated pathways with epithelial-to-mesenchymal (EMT) and TGF-beta signaling whereas SL was up-regulation of cell cycle and WNT signaling pathway. The LAR subtype was activated of androgen and estrogen receptor pathway. Although metastatic TNBC generally shared equal activity of key pathways with primary, coagulation, toll-like receptors, TNF, and Jak-STAT signaling pathways were dysregulated in metastasis. Especially, SPP1 gene expression to induce metastasis was associated with poor prognosis. DRscores were discriminative in CMS of meta-data and biobank expression profile. We found subtype-specific 18 drugs as therapeutic candidates and these drugs were also correlated with key pathways. In a case of cisplatin, DRscores appear resistant in MSL while response in SL. Our patients’ expression profiles were shown to consistent result as well as biobank. Conclusion: These finding might facilitate understanding heterogeneity of TNBC. Our novel approach to explore drug response suggested functional intervention landscape of drug response without in-vivo experiment. Taken together, we propose biomarkers for diagnosis and also suggest therapeutic strategy depending on CMS. Citation Format: Jihyun Kim, Doyeong Yu, Jiyoon Noh, Wooyeong Jang, Hanna Yang, Youngmee Kwon, Keun Seok Lee, Sung Hoon Sim, Sun-Young Kong, In Hae Park, Charny Park. Consensus molecular subtype of triple negative breast cancer to implicate in chemotherapy response [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3424.
Flu Protector
Authors: Tracy Hampton
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Epidemiologic Necropsy for Abdominal Aortic Aneurysm
Authors: Michael J. McFarlane
Journal: JAMA (1991)

The epidemiologic necropsy measures the occurrence of unsuspected disease through the examination of necropsy records. The estimates of unsuspected disease should approximate what occurs in the living population. The necropsy records of the University of Kansas Medical Center (Kansas City) from 1950 to 1984 were examined for the occurrence rate of abdominal aortic aneurysms. Each adult patient was categorized as (1) without abdominal aortic aneurysm, (2) abdominal aortic aneurysm discovered as a necropsy surprise, or (3) abdominal aortic aneurysm diagnosed or suspected during life. Necropsy detection rates of unsuspected abdominal aortic aneurysms were compared with those found in five published screening surveys. The necropsy detection rate in men was 81 (0.019) of 4155 and was 28 (0.009) of 3142 in women, a difference that was statistically significant. When the necropsy series was adjusted to reflect the same demographic composition as the screening surveys, the results from necropsy and screening were statistically similar. In particular, two surveys from the United Kingdom showed screening detection rates among white men of 0.072 compared with a necropsy detection rate of 0.058. These results further support the use of the epidemiologic necropsy as a research tool for estimating the reservoir of disease in the population. (<i>JAMA</i>. 1991;265:2085-2088)
Book Review Patient Safety: Achieving a New Standard for Care (Quality Chasm Series.) Edited by Philip Aspden, Janet M. Corrigan, Julie Wolcott, and Shari M. Erickson. 528 pp. Washington, D.C., National Academies Press, 2004. $44.95. 0-309-09077-6 Accountability: Patient Safety and Policy Reform (Hastings Center Studies in Ethics.) Edited by Virginia A. Sharpe. 276 pp. Washington, D.C., Georgetown University Press, 2004. $49.95. 1-58901-023-X
Authors: Peter P. Budetti
Journal: New England Journal of Medicine (2005)
Areawide planning for emergency services
Authors: R. M. Sigmond
Journal: JAMA (1967)

For areawide health planning to be effective, the distinction between emergency and non-emergency services must be recognized. At the same time, it is important that the significant interrelationships of these services be considered in initial planning. It might appear that areawide planning simply involves estimation of the relative volume of care requiring emergency and non-emergency treatment, with an allocation of resources and a configuration of services reflecting the estimated needs. Unfortunately, such planning is more complex. Current patient volume in emergency facilities already exceeds estimates of the need for "true" emergency care, as defined by physicians, and the volume is rising. Continued adaptation of emergency departments to the increasing demand will result in their gradual conversion into ever larger impersonal health supermarkets—into second-rate health centers, ill-adapted for either emergency services or general ambulatory care. Certain adjustments in the total system of providing health services could lead to a reduction in
Authors’ Reply
Authors: Steven Fishbane, Mohamed A. El-Shahawy, Bui Pham Van, Dustin J. Little
Journal: Journal of the American Society of Nephrology (2021)

We thank Eleftheriadis et al.1 for their attention to our manuscript, "Roxadustat for Treating Anemia in Patients with CKD Not on Dialysis: Results from a Randomized Phase 3 Study,"2 and their letter on the potential effects of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors on adaptive immunity. We support basic scientific research to explore various aspects of HIF biology. However, we would like to emphasize that it is complex to translate findings from in vitro experiments studying the consequences of HIF stabilization to clinical observations. In the findings cited by Eleftheriadis et al.,3 human PBMCs were exposed to various concentrations (1, 5, 10, or 15 μg/ml) of roxadustat for 7 days, resulting in continuous HIF stabilization, with the 5 and 10 μg/ml concentrations being similar to the maximum plasma concentrations reported among patients who received 1.0 or 2.0 mg/kg of roxadustat.4 In the OLYMPUS study,2 roxadustat was administered three times weekly, at least 2 days apart, at a starting dose of 70 mg (maximum dose was capped at the lower of 3.0 mg/kg or 300 mg) for up to 4 years. With three times weekly dosing and a t1/2 of approximately 12 hours, plasma concentrations of roxadustat generally return to very low levels between doses, resulting in intermittent (not continuous) HIF stabilization.4,5 With this in mind, we recommend caution in considering the applicability of data generated with continuous HIF stabilization in preclinical experiments to intermittent HIF stabilization with roxadustat in clinical settings. Disclosures B.P. Van reports research support and consulting fees from AstraZeneca. S. Fishbane reports consultancy agreements with AstraZeneca, Akebia, Cara Therapeutics, and Fibrogen; research funding from AstraZeneca, Cara, Gilead, and Fibrogen; hHonoraria from AstraZeneca and Akebia; and being a scientific advisor or membership from AstraZeneca and Fibrogen. M. EI-Shahawy reports ownership interest in Paramount Hope Dialysis Center and East LA Dialysis Center; research funding from AztraZeneca, Pfizer, Bayer, UCB, and Sanofi; honoraria from AstraZeneca; being a scientific advisor or membership with AztraZeneca and Bayer; and speakers bureau from AstraZeneca. D.J. Little is employed by and has ownership interest in AstraZeneca. D.J. Little also reports other interests/relationships as a volunteer nephrologist at Walter Reed National Military Medical Center. Funding Funded was provided by AstraZeneca. Medical writing support was provided by Shaun W. Foley, of Core Medica (London, UK), which was funded by the study sponsor.
Controversial Practices in Allergy-Reply
Authors: Michael H. Grieco
Journal: JAMA (1983)

<h3>In Reply.—</h3> Radioallergosorbent titration was considered in my discussion of "Controversial Practices in Allergy" and included comparison of modified RAST and Phadebas RAST. The report of Santrach et al<sup>1</sup>was cited, which examined non-IgE-containing control specimens. They reported that radioactive binding produced by fetal calf serum and pooled human cord serum was sufficient to score as class 1 in one of 21 modified RAST assays, whereas human serum albumin scored as class 1 in serum of 21 assays. It would have been more appropriate for me to state that non-IgE-containing control preparations produced "equivocal" results in up to seven of 21 modified RAST assays than to have referred to 33% false-positive results. This same study reported negative nasal provocation test results in five of eight modified RAST class 1 patients and underscored the relative nonspecificity of the class 1 designation. In 1980, Hoffman<sup>2</sup>reported results on comparison of
Journal Advertising
Authors: GEOFFREY LEFFERTS
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 April 1978Journal AdvertisingGEOFFREY LEFFERTS, M.D.GEOFFREY LEFFERTS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-581_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I was very disappointed by the editorial "Advertising and Our Journal" (Ann Intern Med 87:114-115, 1977). Four statements are especially distressing.First is the declaration that "drug advertisements in peer-review journals are a vital part of continuing pharmacologic education." An organization that produces such excellent educational efforts as the Annual Sessions, the MKSAP packages, the yearly series of Postgraduate Courses, and this journal does not have to tout pure commercial advertising as educational. In fact, drug advertising has traditionally been so dishonest that it has fallen under regulation by the federal government. Drug advertisements are so incomplete... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Box 128; Towanda, PA 18848 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPrescription drug advertising: Trends and implications 1 April 1978Volume 88, Issue 4Page: 581-581KeywordsDrug regulationDrugs Issue Published: 1 April 1978 PDF DownloadLoading ...
Primary subacute haematogenous osteomyelitis.
Journal: BMJ (1969)

Leading Articles MCBRLTSJHURNAL two days.By the end of the third week the ulcer niche had disappeared in 87%.Thus admission to hospital and regular treatment with alkalis and milk were apparently the main reason for their success.Diet could still have had a minimal effect, but an effect which was not measurable because the ulcers improved so rapidly once the patients were admitted and given alkalis.Other workers have come to the same conclusions from clinical trials of the effect of diet on active duodenal ulcer.B. M. Nicol4 studied a group of inpatients with gastric and duodenal ulcers and concluded that the results were as good with a " full diet " as with a strict dietary regimen.J. S. Lawrence5 found that in 140 inpatients neither healing nor disappearance of pain due to gastric, duodenal, and jejunal ulcers was improved by a diet of regular milk and eggs.R. Doll and colleagues6 gave outpatients with duodenal ulcers normal and special diets.There was no significant difference in healing of the ulcers.S. C. Truelove7 came to the same conclusion on treating 80 male outpatients with duodenal ulcers who were followed up for six months.Thus five clinical trials have pointed to the same conclusion about the ineffectiveness of diets for duodenal ulcers.Though each of these studies can be criticized in one way or another, the fact that not one showed diets to be specifically beneficial is surely significant.Most of the dietary restrictions that we impose on our patients with duodenal ulcers are based on " unverified impressions and traditional lore."8Should we not advise those with symptomatic duodenal ulcers to enjoy the food they like, to avoid items that make their symptoms worse, and to take regular alkalis or milk ?There is at present no reason for us to claim that bland diets help the symptoms or healing of duodenal ulcers.
Correspondence
Authors: A. Vahlquist
Journal: British Journal of Dermatology (1982)

Journal Article Correspondence Get access A. Vahlquist A. Vahlquist Department of Dermatology, University of Uppsala, Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 1, 1 July 1982, Pages 125–126, https://doi.org/10.1111/j.1365-2133.1982.tb00303.x Published: 01 July 1982
Diet in Sickness and in Health.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcohol and Man: The Effects of Aloohol on Man in Health and Disease.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal