tbuckley/cabot-search huggingface dataset:
ONDINE'S CURSE
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proctology
Authors: E. Parker Hayden, Thad A. Krolicki
Journal: New England Journal of Medicine (1945)

THE diagnosis and treatment of most diseases of the anus, rectum and colon have become fairly standardized over a period of years. Good therapeutic results can be obtained by careful attention to detail in history taking, examination, operative procedures and aftercare. A diagnosis can often be made on the history alone, although many serious mistakes have also occurred because of reliance on the history to the exclusion of a thorough examination by index finger, anoscope, sigmoidoscope and x-ray.The cardinal symptoms of bleeding, pain, swelling, itching and disturbance of the normal bowel habits of the patient in question constitute the . . .
Cholecystectomy and abdominal hysterectomy
Authors: J. M. Murray
Journal: JAMA (1980)

Cholelithiasis is a common disease in women and can lead to serious complications. At Wilford Hall USAF Medical Center, we have performed 21 cholecystectomies at the time of abdominal hysterectomy. All patients had been asymptomatic with regard to gallbladder disease, but showed either preoperative or intraoperative evidence of gallbladder disease. The mean surgical time was 3.3 hours, mean blood loss was 474 mL, and only one patient had febrile morbidity (&gt;38.3<sup>°</sup>C). Because of the low morbidity, we recommend that this combined surgical approach be considered by both the gynecologist and general surgeon. (<i>JAMA</i>244:2305-2306, 1980)
BOOK REVIEWS
Authors: L. VALENTINO, H. KAIZER
Journal: JNCI Journal of the National Cancer Institute (1991)

BOOK REVIEWS Bone Marrow Transplantation In Children . F. Leonard Johnson , Carl Pochedly , eds. New York : Raven Press , 1990 , 551 pp. $125. LEONARD VALENTINO, LEONARD VALENTINO Bone Marrow Transplant Center, rush-Presbyterian-St. Luke's, Medical Center1653W Congress Pkwy, Room 325, Chcago, IL 60612 Search for other works by this author on: Oxford Academic PubMed Google Scholar HERBERT KAIZER HERBERT KAIZER Bone Marrow Transplant Center, rush-Presbyterian-St. Luke's, Medical Center1653W Congress Pkwy, Room 325, Chcago, IL 60612 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 1, 2 January 1991, Page 58, https://doi.org/10.1093/jnci/83.1.58 Published: 02 January 1991
New test for thyrotoxicosis?
Journal: BMJ (1965)

New Test for Thyrotoxicosis?In most patients with thyrotoxicosis the diagnosis can be made on clinical grounds alone.'In almost all the remaining patients in whom the diagnosis is more difficult the results of radioiodine (13'I) studies and determinations of proteinbound stable iodine (P.B.1271I) in the serum are adequate guides to the diagnosis.These considerations are rather less true, however, when thyrotoxicosis is suspected during pregnancy.In normal pregnancy complaints of tiredness, palpitation, dyspnoea, and intolerance to heat are not uncommon, and when these symptoms are associated with hot, moist hands, tachycardia,
Seasonal Variations in Levels of DNA Adducts and X-Spots in Human Populations Living in Different Parts of Poland
Authors: Ewa Grzybowska, Kari Hemminki, Mieczyslaw Chorazy
Journal: Environmental Health Perspectives (1993)

White blood cell DNA adducts were measured in coke oven workers, in residents from the area next to the coke oven in Silesia, Poland (highly industrialized region), and in residents from the rural area of Poland using the 32P-postlabeling technique. This method detected aromatic adducts including adducts formed by polycyclic aromatic hydrocarbons (PAHs). Highest levels of adducts in DNA were seen in the group of coke battery workers (6.9 adducts/10(8) nucleotides). Seasonal variations in levels of DNA adducts were observed both in residents of the district near the coke oven area and individuals from the rural area of Poland. Blood samples collected from people living near the coke oven in winter showed much higher levels of DNA adducts than blood samples obtained in summer (5.0 adducts/10(8) nucleotides in winter and 1.4 adducts/10(8) nucleotides in summer). The difference in the level of DNA adducts between winter and summer was smaller in the group of people living in the rural area (3.2 adducts/10(8) and 2.2 adducts/10(8), respectively). In most cases the levels of X-spots correlated with the levels of other DNA adducts. Correlation coefficients(r) between the levels of X-spots and other adducts ranged between 0.46 and 0.74 (p < 0.05), except for coke oven workers where no correlation was observed.
Food‐bound B12 absorption and serum total homocysteine in patients with low serum B12 levels
Authors: Aaron Miller, D. Ward Slingerland, Charles A. Hall, Richard C. Chu
Journal: American Journal of Hematology (1998)

This study was undertaken to determine whether measurements of serum total homocysteine (Hcys) and bound B12 absorption are useful in determining which patients with low- or low-normal levels of serum B12 are B12 deficient. In 40 patients with low or borderline serum levels of B12, food-bound B12 absorptions were determined using a body counter in an iron room, and were related to serum total Hcys levels. Food-bound B12 absorption was decreased in 16 patients and in an additional four, absorption of the free vitamin was also decreased. Homocysteine levels were elevated in four of the 16; in three of the four who had both decreased bound and free B12 absorptions, Hcys was elevated. If elevation of the Hcys level indicates tissue deficiency of B12, the 75% incidence of normal levels of Hcys in these patients with low food-bound B12 absorptions suggests the existence of a cohort of patients who may be at risk to develop, but have not yet developed, B12 deficiency. Only long term follow-up will reveal how many ultimately will become B12 deficient. Am. J. Hematol. 59:42–45, 1998. © 1998 Wiley-Liss, Inc.
Course of Lectures on Organic Chemistry: As Applied to Manufactures and Agriculture
Authors: M. Payen
Journal: BMJ (1842)

Dr. Budd has directed attention to the progress of cancer under some of its ordinary phases.Let us state an example: a small, hard knot is detected in the female breast, lying loose in that organ; this tumor enlarges, grows, fastens on the parts around, no longer lies loose in the cellular tissue, but con- tracts adhesions with the surrounding parts, spreads out its claws, as it were, like a crab (hence the name cancer), seizes on the glands of the axilla, and dis- seminates small tumors through the viscera.On examination after death, cancerous matter is detected in the viscera and lymphatic glands, and is frequently found in the lungs, the liver, and peritoneum.From these facts, and from the circumstance that tllc veins aLre found charged with the same cancerous matter, Dr. Budd infers (and a most important inference it, is, if drawn from a sufficient number of authenticated facts) that the secoildary tumors discovered in the
Update: Outbreak of Ebola Viral Hemorrhagic Fever—Zaire, 1995
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mild sickle cell disease. Clinical and laboratory studies
Authors: M. H. Steinberg
Journal: JAMA (1973)

Twenty-one patients with mild sickle cell disease (MSD) between 18 and 56 years of age had mild, infrequent, or no pain crises, were active or employed, and led relatively normal lives. Mean hemoglobin concentration, reticulocyte count, and hemoglobin A<sub>2</sub>and F levels did not distinguish this group from a smaller group of patients with typical sickle cell anemia (SSA). On the basis of electrophoresis, hemoglobin H preparations, and distribution of hemoglobin F in erythrocytes, there was no evidence for thalassemia, hereditary persistence of hemoglobin F, or other hemoglobinopathies that might modify the course of SSA. There may be many host or environmental factors that protect individuals with MSD. Knowledge of these may suggest new therapeutic strategies for the control of SSA.
Entrectinib Effective across <i>NTRK</i> Fusion–Positive Cancers
Journal: Cancer Discovery (2018)

Entrectinib may be an effective therapy for patients with NTRK fusion-positive solid tumors, regardless of tumor type. In a combined analysis of phase I and phase II trials, more than half of patients responded to the drug, with a similar response rate in patients whose cancer had spread to the brain.
Diapers and day care
Authors: Richard Scribner, James Dwyer
Journal: JAMA (1991)

<h3>To the Editor.</h3> —The "randomized trial" by Van et al<sup>1</sup>of diaper type in a day-care center is fundamentally flawed because vital information on potential biases has been omitted. Thus, the missing information should be requested from the authors and provided to the<i>JAMA</i>readership. In the study, the authors used a randomized, cross-over design. Presumably, the design was chosen to yield a definitive study of diaper type in the day-care setting. Instead, they chose to treat diapering like taking a drug. However, a "gold-standard" design for clinical trials is subject to significant biases in the social setting of the day-care environment. First, the care givers were not blinded, raising the question of what was the diaper preference of each of the care givers prior to the study. The authors gave no information on this fundamental point and did not mention it as a potential bias. It is up
Cataracts
Authors: Janet M. Torpy
Journal: JAMA (2003)

CataractsA s part of our visual (sight) system, each eye contains a lens.The lens is a clear, disc-shaped structure behind the pupil and iris.The lens focuses light beams on the retina, the back part of the eye that sends sight signals to the brain.When the lens becomes cloudy, vision blurs.Clouding of the lens is called a cataract.Cataracts are common, especially in older individuals.As a normal part of the aging process, the lens gradually becomes cloudy.A simple eye examination by an ophthalmologist (eye physician) can detect a cataract.The July 9, 2003, issue of JAMA includes an article about cataracts.
Experimental Production of Cerebral Hypothermia by Ventricular Perfusion Techniques
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Royal College of Physicians of London
Authors: J. R. E.
Journal: Annals of Internal Medicine (1968)

ExcerptThe Royal College of Physicians of London was founded in 1518. In 1915 an American physician, Dr. Heinrich Stern, inspired by attending one of the Royal College's comitia, or meetings, returned to found the American College of Physicians. Since then, the two organizations, parent and child, have worked in mutual regard and amity. To make this more evident the American College of Physicians has invited the Royal College to a combined meeting. This occasion—about to take place in Boston—will help our venerable parent College to celebrate its four hundred and fiftieth birthday at the time of this, our own, Forty-Ninth...
Relation between Dietary Linolenic Fatty Acid and Coronary Heart Disease in the NHLBI Family Heart Study
Authors: None MA, James S Pankow, John H Eckfeldt, Aaron R Folsom, Paul N Hopkins, R Curtis Ellison
Journal: Circulation (2001)

0014 Epidemiologic studies suggest that higher consumption of alpha linolenic acid, eicosapentaenoic acid, and docosahexanoic acid is associated with lower risk of coronary heart disease (CHD). Little is known about the influence of the linoleic-to-linolenic ratio on the relation of linolenic acid to CHD. We used data collected on 4,406 participants of the NHLBI Family Heart Study (mean age of 52 years)to examine the relation between dietary linolenic acid and prevalent coronary heart disease and to determine if such a relation was influenced by fish consumption and linoleic-to-linolenic ratio. Dietary linolenic acid was assessed by semiquantitative food frequency questionnaire. We used generalized estimating equations to estimate the odds ratios of coronary heart disease across age- and energy-adjusted quintiles of linolenic acid. From the lowest to the highest quintile of linolenic acid, the prevalence odds ratios (95 % CI) of coronary heart disease were 1.00 (referent), 0.77 (0.49-1.21), 0.51 (0.32-0.81), 0.52 (0.33-0.84), and 0.48 (0.30-0.76), respectively, for men (p for trend 0.0009) and 1.00, 0.55 (0.29-1.04), 0.75 (0.41-1.38), 0.43 (0.21-0.88), and 0.40 (0.20-0.82), respectively, for women (p for trend 0.015), controlling for age, energy intake, anthropometric, lifestyle, and metabolic factors. This association was observed across all categories of fish consumption frequency. When stratified by tertiles of linoleic-to-linolenic ratio (ranges of 2.3-8.4, 8.5-11.1, and 11.2-64.0), a statistically significant inverse relation between linolenic acid and CHD was observed only in the lowest tertile of linoleic-to-linolenic ratio (p for trend 0.0001, 0.39, and 0.13, respectively, for the first, second, and third tertile of linoleic-to-linolenic ratio). In conclusion, these data suggest an inverse relation between dietary linolenic acid intake and prevalent coronary heart disease in both sexes, independent of fish consumption. A lower ratio of linoleic-to-linolenic fatty acid might be necessary to observe the benefits of linolenic acid on coronary heart disease.
Adoption of International System of Units for Clinical Chemistry
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Three-Drug Chemotherapy Combination Increases Organ Preservation in Patients with Larynx Cancer
Journal: JNCI Journal of the National Cancer Institute (2009)

Three-Drug Chemotherapy Combination Increases Organ Preservation in Patients with Larynx CancerPatients with larynx cancer who received a three-drug combination of docetaxel, cisplatin and 5-fl uorouracil (TPF) during induction chemotherapy were more likely to retain larynx function than were patients treated with cisplatin and 5-fl uoruracil (PF) alone, according to data from a randomized controlled trial in the March 24 online issue of the Journal of the National Cancer Institute .Patients with locally advanced larynx and hypopharynx cancer are treated frequently with PF chemotherapy followed by radiation as an alternative to surgical removal of the larynx.Recent trials have suggested that adding docetaxel to PF might further improve patient outcomes.To test this possibility, Gilles Calais, M.D., of the Centre Hospitalier Régional et Universitaire de Tours in France, and colleagues enrolled 213 patients with advanced larynx and hypopharynx cancer in a randomized controlled trial.Patients received induction chemotherapy with either TPF or PF.Those who responded to chemotherapy underwent subsequent radiation therapy, while those who did not respond were treated with surgery.With a median follow-up time of 3 years, the estimated larynx preservation rate was 70.3 percent in the TPF-treated patients and 57.5 percent in the PF-treated patients.Overall, 80.0 percent of patients in the TPF group responded to therapy, compared with 59.2 percent in the PF group.Patients treated with TPF had more severe infections than those treated with PF.The authors conclude that the treatment regimen with docetaxel was superior for patients with locally advanced cancers of the larynx and hypopharynx and that more of these patients could avoid total laryngectomy.However, they caution that "Because we proposed treatment to a select population of patients with only larynx and hypopharynx cancer and this trial was especially designed for organ preservation, we cannot generalize the fi ndings to all locally advanced head and neck cancers."
Abstract 2015: Downregulation of MZB1 by aminoguanidine, APOE mimetic and nitroxyl compounds associated with reduction in invasive breast tumor volume and metastasis
Authors: Yuk Sing Robert Cheng, Debashree Basudhar, Rdinour Lisa, Veena Somasundaram, David Wink
Journal: Cancer Research (2019)

Abstract Triple negative breast cancer (TNBC) is notoriously known for poor prognosis due to a lack of actionable molecular target(s). Remarkably, the majority of TNBC patients suffer the cancer relapse even they receive treatment given for early stage breast cancers. Up-to-date, lots of therapeutic agents have been developed and actionable molecular targets have been proposed. Nevertheless, the survival rate for metastatic invasive breast cancer is low because of poor prognosis. In this study, we determined whether different classes of chemo-agents (or compounds) interact with different cellular and molecular pathways they might share some common pathway(s) if their therapeutic outcome is similar. We first tested the effect of aminoguanidine (AG), APOE mimetics (COG), and nitroxyl (HNO) compounds on carcinogenesis and metastasis using an orthotopic breast cancer model. In vivo imaging analysis indicated that these compounds significantly reduced the tumor loading in the xenografts (MDA-MB-231-GFP). Moreover, compounds AG and COG are able to reduce brain metastasis significantly. RNA-Seq analysis identified only one gene which is commonly altered in all treatment groups. This gene encodes marginal zone B and B1 cell specific protein (MZB1). MZB1 was downregulated after treatment and its expression was inversely correlated with the efficacy of brain metastasis. In addition, pathway comparison analysis of RNA-Seq data revealed there are three top canonical pathways including (1) Role of NFAT in Regulation of the Immune Response, (2) PKC theta Signaling in T Lymphocytes, and (3) iCOS-iCOSL Signaling in T Helper Cells, downregulated in all treatment groups. In conclusion, our findings demonstrated three different classes of compounds can reduce not only tumor loading but metastasis. MZB1, identified from our transcriptome analysis, may serve as an actionable molecular target for TNBC. All-in-all, it provides new insights into the development of new therapeutic targets and biomarkers for TNBC. Citation Format: Yuk Sing Robert Cheng, Debashree Basudhar, Rdinour Lisa, Veena Somasundaram, David Wink. Downregulation of MZB1 by aminoguanidine, APOE mimetic and nitroxyl compounds associated with reduction in invasive breast tumor volume and metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2015.