tbuckley/cabot-search huggingface dataset:
Medical News Pocket Formulary for 1899.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma-chloride Levels in Hyperparathyroidism
Authors: M. G. McGeown, D. W. Neill
Journal: BMJ (1964)

those in which there was some doubt as to the diagnosis and laparotomy was carried out and biopsy taken.We have noted the relatively common occurrence of carcinoma of the prostate in this region; this is not mentioned in the Kampala series, though there seems no obvious reason to account for this.
EPISODIC MONOARTHRITIS AND ETHNIC ORIGINS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Telomere Diseases
Authors: Rodrigo T. Calado, Neal S. Young
Journal: New England Journal of Medicine (2009)

The Nobel Prize in Physiology or Medicine 2009 was recently awarded to three scientists for their work on telomeres, which are repetitive DNA structures at the tips of chromosomes, and the enzyme telomerase. Telomeres protect the genome from loss of genetic material. This review recounts the medical implications of telomeres and focuses on a group of diseases in which the loss of telomeres appears to be causal.
MEDICAL EDUCATION.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Migraine as a Risk Factor for Subclinical Brain Lesions—Reply
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wilms' tumor and congenital aniridia
Authors: J. F. Fraumeni
Journal: JAMA (1968)

Among 28 children under 4 years of age hospitalized with congenital aniridia, Wilms' tumor subsequently developed in six and one had the neoplasm on admission. Five of these seven patients have not, to our knowledge, been reported previously, bringing to 22 the total number of cases known with this association. Although one child in our series had familial aniridia, all other cases of aniridia with Wilms' tumor have been sporadic, suggesting that the two disorders originate by common or concurrent gene mutation or by environmental effects on embryogenesis. The aniridia-Wilms' tumor complex includes an array of nonocular anomalies, providing further evidence that the neoplasm is but one manifestation of a distinctive syndrome.
Correction: <i>Dual oxidase 1 limits the IFNγ-associated antitumor effect of macrophages</i>
Authors: Yu-Pei Chen, Ya-Qin Wang, Yan-Ping Mao, Ying-Qing Li, Shuo-Yu Xu, Xiao-Min Li, Qing-Mei He, Shi-Wei He, Xiao-Jing Yang, Yuan Lei, Yin Zhao, Jing-Ping Yun, Yingqin Li
Journal: Journal for ImmunoTherapy of Cancer (2020)
TREATMENT OF CANCER
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of renal masses in an octogenarian cohort: Is there a right approach?
Authors: Jude Nawlo, Dominic H. Tang, Juan Chipollini, Scott Michael Gilbert, Michael Adam Poch, Wade Jeffers Sexton, Julio Pow-Sang, Philippe E. Spiess
Journal: Journal of Clinical Oncology (2017)

497 Background: Although several guidelines outline management options for patients with renal masses, few studies describe treatment strategies and outcomes in octogenarians. We sought to review outcomes in this population managed with active surveillance (AS), partial nephrectomy (PN), or radical nephrectomy (RN). Methods: Data were collected on 113 octogenarian patients referred for management of renal masses at Moffitt Cancer Center between 2000 and 2013. Patients were treated with AS, PN, or RN. Univariate and multivariable Cox regression models measured association of management modality and survival. Kaplan-Meier survival analysis was used for overall survival and log-rank tests were used to compare survival curves. Covariates include age, Eastern Cooperative Oncology Group (ECOG) score, clinical and pathologic stage, tumor size, creatinine, creatinine clearance, and overall survival. Results: Out of 113 patients, 27 (22%) underwent AS, 33 (26.8%) underwent PN, and 53 (43%) underwent RN. The mean age was 83 years (range, 80-92). AS patients had a higher mean age (84 years) than PN patients (81.9 years), but not with RN patients (83 years) (p=0.008). At a median follow-up of 30.6 months (IQR 9.9-56), 13 (48%), 10 (30.3%), and 29 (54.7%) patients died from any cause in AS, PN, and RN patients respectively. PN patients tended to have a longer median overall survival at 81 months versus 55.8 and 57 months for AS and RN respectively, but this did not reach statistical significance on univariate (p=0.588) or multivariate analysis (p=0.29). On subgroup analysis of cT1a patients, there was also no difference in overall survival among treatment arms on univariate (p=0.654) and multivariate analysis (p=0.47). At 1 year follow-up, there was no difference in creatinine levels between treatment arms (p=0.331). However, mean creatinine clearance was lower in RN patients (35.8 ml/min) compared to AS (50.7 ml/min) and PN (48.1 ml/min) (p=0.024). Conclusions: Active treatment with PN and RN may not provide a survival advantage among octogenarians. Renal function was inferior in RN patients but comparable between AS and PN patients at 1 year follow-up.
Exercise Prescription
Authors: John F. Whitney, Gary H. Lyman
Journal: Annals of Internal Medicine (2002)

Medical Writings: Book Notes2 April 2002Exercise PrescriptionJohn F. Whitney, MD and Gary H. Lyman, MD, MPHJohn F. Whitney, MDAlbany Medical College, Albany, New York.Search for more papers by this author and Gary H. Lyman, MD, MPHAlbany Medical College, Albany, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-7-200204020-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Swan DP, Leutholtz BC. 188 pages. Champaign, IL: Human Kinetics; 2002. $22.00. ISBN 0736037543. Order phone 800-747-4457.Field of medicine: Exercise physiology, sports medicine, and athletic training.Format: Softcover book.Audience: Physicians, physician assistants, nurse practitioners, and athletic trainers interested in a concise and current reference on how to advise and structure evidence-based exercise training regimens for patients with a variety of health and wellness concerns.Purpose: To use case-study methods to aid students and exercise professionals in putting the American College of Sports Medicine (ACSM) exercise training recommendations into clinical practice.Content: This well-organized text begins with an introduction ... Author, Article, and Disclosure InformationAffiliations: Albany Medical College, Albany, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 April 2002Volume 136, Issue 7Page: 564KeywordsElderlyExerciseInterleukinsMuscular dystrophiesNursesPregnancySoftware toolsSportsSports and exercise medicineWeight loss ePublished: 2 April 2002 Issue Published: 2 April 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
MILK SUGAR IN INFANCY
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Table of Contents
Authors: Giorgina Piccoli, Mona Alrukhaimi, Zhi-Hong Liu, Elena Zakharova, Adeera Levin, Kristin Meliambro, Kirk Campbell, Christina Wyatt, Yannick Le Meur, Ora Weisz, Catherine Baty, Adriana Dusso, Maria Colombo, Catherine Shanahan, Barbara Reich, Susanne Viehmann, Christian Kurts, Paul Perco, Gert Mayer
Journal: Kidney International (2018)
Abstract 1019: Intracellular Calcium Cycling Mediates Proliferation and Differentiation of Human Cardiac Stem Cells
Authors: Roberto Rizzi, Michael L Arcarese, Grazia Esposito, Claudia Bearzi, Justin A Korn, Andrea Di Marco, Tymoteusz J Kajstura, Toru Hosoda, Elisabeth Steadman, Konrad Urbanek, Domenico D’Amario, Edmund H Sonnenblick, Annarosa Leri, Piero Anversa, Marcello Rota
Journal: Circulation (2007)

Human cardiac stem cells (hCSCs) are self-renewing, clonogenic and have the ability to differentiate into myocytes, smooth muscle and endothelial cells in vitro and in vivo. Since Ca 2+ plays a crucial role in mechanotransduction and activation of signalling pathways in mature cardiac cells, intracellular Ca 2+ cycling was studied in hCSCs to determine the function of this cation in cell division and commitment to the myocyte lineage. For this purpose, hCSCs were exposed to conditions favouring proliferation and differentiation and affecting intracellular Ca 2+ homeostasis. Moreover, hCSCs were loaded with Fluo-3 and intracellular Ca 2+ levels were monitored by 2-photon microscopy. hCSCs presented spontaneous Ca 2+ spikes mediated by Ca 2+ release from the endoplasmic reticulum (ER). ATP and histamine, which stimulate InsP 3 R-mediated ER Ca 2+ release, increased the occurrence of spikes leading to oscillations in intracellular Ca 2+ . 2-APB, an antagonist of InsP 3 R, inhibited spike formation and oscillatory events. Ryanodine, which acts on the ryanodine receptors, did not alter intracellular Ca 2+ and thapsigargin, a Ca 2+ pump blocker, prevented spontaneous and induced ER Ca 2+ release. Store operated capacitative Ca 2+ entry was evoked by increasing extracellular Ca 2+ after depletion of the ER. Ca 2+ entry was blocked by lanthanum. Additionally, patch-clamp experiments indicated the absence of the voltage-activated L-type Ca 2+ current in hCSCs. Exposure of hCSCs to IGF-1 triggered acutely Ca 2+ spikes and increased chronically their occurrence. Over a period of 24 hours, IGF-1 resulted in more than 100% increase in the proliferation of hCSCs measured by BrdU labelling. Similarly, ATP enhanced proliferation of hCSC by ~60%. Importantly, incubation with 2-APB reduced by ~50% BrdU incorporation and abolished the effect of IGF-1 and ATP on both Ca 2+ spikes and cell proliferation. In the presence of differentiating medium, the frequency of Ca 2+ spikes in active hCSCs increased significantly. Additionally, enhanced Ca 2+ cycling increased the number of hCSCs committed to the myocyte lineage, while attenuations in this phenomenon blunted hCSC differentiation. Thus, InsP 3 R-mediated Ca 2+ spikes play an obligatory role in hCSC growth and differentiation.
Endothelial Cell Cytotoxicity of Cotton Bracts Tannin and Aqueous Cotton Bracts Extract: Tannin Is the Predominant Cytotoxin Present in Aqueous Cotton Bracts Extract
Authors: Christopher M. Johnson, Michelle Nyberg Hanson, Michael S. Rohrbach
Journal: Environmental Health Perspectives (1986)

Using an in vitro cytotoxicity assay based on the release of 51Cr from cultured porcine thoracic aortic and pulmonary arterial endothelial cells, we have demonstrated that cotton bracts tannin is a potent endothelial cell cytotoxin. It produces dose-dependent lethal injury to both types of endothelial cells with the aortic cells being somewhat more sensitive to tannin-mediated injury than the pulmonary arterial cells. Cytotoxic injury to the cells was biphasic. During the first 3 hr of exposure to tannin, no lethal injury was detected. However, during this period, profound changes in morphology were observed suggesting sublethal injury to the cells preceded the ultimate toxic damage. Comparison of the cytotoxicity dose curves for aqueous bracts extracts with those for tannin demonstrated that tannin was the major cytotoxin present in bracts.
Prevention and management of adverse events of Novel agents in multiple myeloma: A consensus of the european myeloma network
Authors: H Ludwig, M Delforge, T Facon, H Einsele, F Gay, P Moreau, H Avet-Loiseau, M Boccadoro, R Hajek, M Mohty, M Cavo, M A Dimopoulos, J F San-Miguel, E Terpos, S Zweegman, L Garderet, M-V Mateos, G Cook, X Leleu, H Goldschmidt, G Jackson, M Kaiser, K Weisel, N W C J van de Donk, A Waage, M Beksac, U H Mellqvist, M Engelhardt, J Caers, C Driessen, P Sonneveld
Journal: Leukemia (2017)

During the last few years, several new drugs have been introduced for treatment of patients with multiple myeloma, which have significantly improved treatment outcome. All of these novel substances differ at least in part in their mode of action from similar drugs of the same drug class, or are representatives of new drugs classes, and as such present with very specific side effect profiles. In this review, we summarize these adverse events, provide information on their prevention, and give practical guidance for monitoring of patients and for management of adverse events.
Suffering
Authors: Nicholas P. Lang
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of an Oral Contraceptive
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author Correction
Journal: Journal of Clinical Oncology (2011)

The authors discovered that the file used to identify matched controls was incomplete, affecting the estimates of relative survival.After combining the original control file with a control file from an earlier Surveillance, Epidemiology, and End Results-Medicare linkage, the authors reran the analyses using the corrected database.Because the number of potential controls increased, 99% of cases were matched with a control, instead of 97% as previously reported.Differences between cases and controls in sociodemographics and comorbidities remained small (ie, Ͻ 4%).As such, the overall results and
Statistics of One Thousand Cases in Obstetrics
Authors: I. Harrinson
Journal: BMJ (1859)

He improved in general appearance, but gradually lost voluntary muscular energy all over the body.For three or four weeks, commenciDg about the middle of April, his sight (ordinarily perfect) was affected to an extent which prevented him from reading anything but large print, and he became so deaf that he was unable to join in ordinary conversation.Early in May, he went to the seaside, but continued to get more feeble, andl frequently fell down in walking across the room, and was then unable to rise without assistance.After staying at the seaside a fortnight without benefit, and no twitching or other effects being produced by the strychnia, the dose of this medicine was increased from one-eighth of a grain four times to one-fourth of a grain three times a day.After the fourth