tbuckley/cabot-search huggingface dataset:
A TESTIMONY.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Runaway children
Authors: W. M. Schmidt
Journal: JAMA (1975)

ADOLESCENTS and children are running away from home, hitting the road, living on the street, more than ever before. Evidence of this has been brought out before the Subcommittee to Investigate Juvenile Delinquency of the Senate Committee on the Judiciary and confirmed by the experience of private agencies and studies such as that of the Massachusetts Committee on Children and Youth. It is not a new thing for young persons to run away from home. In years past, some ran away to make their fortune, some to find work, some because of family crisis. A 17th century example is that of one John Dane, a young Englishman whose father "toke a stick and basted me... [when] I went to a dansing scoll to larne to dans." John took off for New England, where after a time "he was joined by his parents and reconciled to them" (Bremner R (ed):<i>Children</i>
Screening for Sulphonylureas in the Investigation of Hypoglycaemia
Authors: P Y P Kwong, J D Teale
Journal: Journal of the Royal Society of Medicine (2002)

The most important cause of hypoglycaemia in the presence of high insulin and C-peptide concentrations is insulinoma. However, a similar picture arises from use of sulphonylureas, which is sometimes covert. All specimens received in two years by a supraregional assay service laboratory from adults with low glucose and inappropriately high insulin and C-peptide concentrations were tested for sulphonylureas by a radioimmunoassay that employed antibodies to glibenclamide. In sulphonylurea-positive cases a questionnaire was sent to the consultant responsible for the patient, to elicit further information. Samples from 93 adult patients met the criteria, and 34 (37%) of these gave a positive result on screening for sulphonylureas. The consultants provided further information on 31 of the 34, and in 20 the presence of a sulphonylurea was unexpected. In 10 the features were such as to raise the possibility of factitious drug ingestion. A simple screening technique applied to specimens from patients with hyperinsulinaemic hypoglycaemia indicated that, in a substantial proportion of cases, the patient was taking a sulphonylurea.
Some Considerations concerning Multimedia-Multipollutant Risk Assessment Methodology: Use of Epidemiologic Data for Non-Cancer Risk Assessment in Russia
Authors: Larissa I. Privalova, Karen E. Wilcock, Boris A. Katsnelson, Susan E. Keane, Kathleen Cunningham, Sergey V. Kuzmin, Sergey A. Voronin, Boris I. Nikonov, Vladimir B. Gurvich
Journal: Environmental Health Perspectives (2001)

The highly industrialized small town of Verkhnyaya Pyshma (in the Urals region of Russia) was chosen as the site of a multimedia-multipollutant risk assessment using the U.S. Environmental Protection Agency methodology.The assessment was based on routine environmental pollution monitoring data for ambient air, soils, drinking water, and food, and the international environmental epidemiology literature.Using an a priori set of the preliminary health-based criteria, we selected nine pollutants for risk assessment: total suspended particles (TSP), sulfur dioxide, nitrogen dioxide, benzo(a)pyrene (BaP), ammonia arsenic, copper, cadmium, and lead.We used dose-response functions derived from epidemiologic studies to assess individual and population risks for TSP, SO 2 , NO 2 , As, Cd, and Pb.We assessed both cancer (for BaP, As, and Cd) and non-cancer (for all the chosen pollutants but BaP) responses, but in this paper we discuss only the assessments of noncarcinogenic risks due to TSP, SO 2 , NO 2 , Pb, and Cd as examples of how the quantitative estimates of health effects can be produced by using a risk function approach.We also schematically present a modified conceptual model of multimedia-multipollutant risk assessment taking into account the experience gained with this study.
THE MEDICAL SITUATION IN RUSSIA.
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE BRITISH ARMY MEDICAL OFFICER.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: Rajeev Ramchandran, David Diloreto, Mina Chung, David Kleinman, Ronald Plotnik, Paul Graman, James Aquavella, Martina Herwig, Jill Wells, Hans Grossniklaus, Luca Fania, Maria Giannico, Romina Fasciani, Anna Zampetti, Simone Ambrogio, Emilio Balestrazzi, Claudio Feliciani, John Landers, Keith Martin, Nicholas Frcophth, Rupert Frcophth, Peter Bourne, Jason Solus, Henry Jampel, Patricia Tracey, Donna Gilbert, Tara Loyd, Joan Jefferys, Harry Scm
Journal: Ophthalmology (2012)
Physician Service Opportunities Abroad
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 796: Progestins target mitochondrial respiration to shift metabolic phenotype in luminal breast cancer
Authors: Shawna B. Matthews, Lynsey M. Fettig, Ashley V. Ward, Matthew R. Jackman, Paul S. MacLean, Carol A. Sartorius
Journal: Cancer Research (2019)

Abstract The dichotomous nature of progesterone receptor (PR) in estrogen receptor (ER)-positive breast cancers has confounded its use as an endocrine target. Historically, progestins were used to treat some advanced breast cancers and ongoing clinical trials are testing several PR ligands. PR generally opposes ER activity through multiple mechanisms, most notably by altering global ER transcriptional activity to suppress breast tumor growth. However, progestins can also stimulate expansion of endocrine-resistant cancer stem cells (CSCs). Thus, better understanding of potential consequences of progestins in breast cancer is necessary to gauge therapeutic efficacy. Given that ER-driven tumor growth relies on mitochondrial respiration, we evaluated whether PR modulates cell metabolism machinery as a mechanism of ER antagonism. We used functional and morphometric assays in an ER+ breast cancer cell line and patient-derived tumor models to show that progestin treatment dramatically alters mitochondrial function. Multivariate metabolomics analysis highlights a progestin-associated metabolic signature involving accumulation of multiple TCA cycle intermediates, including fumarate, malate, and succinate. Functional assays indicate that progestins impair mitochondrial oxidative reserve capacity and oxygen consumption while ablating estradiol-induced accumulation of ATP in PR+ but not PR− cells. Morphometric assessment of mitochondria via laser-scanning confocal and transmission electron microscopy indicate a shift away from reticular filamentous mitochondria towards smaller, rounder, more perinuclear mitochondria with altered membrane potential. These results suggest that PR targets mitochondrial respiration as part of a broader strategic shift from ER-driven tumor growth to PR-driven thrifty metabolic dormancy. Whether the latter is indicative of an acquired propensity for glycolytic metabolism in indolent tumor cells, CSCs, or perhaps both, is addressed in ongoing studies. Citation Format: Shawna B. Matthews, Lynsey M. Fettig, Ashley V. Ward, Matthew R. Jackman, Paul S. MacLean, Carol A. Sartorius. Progestins target mitochondrial respiration to shift metabolic phenotype in luminal breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 796.
Thérapeutique médicale. I. Maladies du tube digestif.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2602: Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signaling.
Authors: Olivier De Wever, Astrid De Boeck, An Hendrix, Hannelore Denys, Geert Braems, Marc Bracke
Journal: Cancer Research (2013)

Abstract Objective: Bone marrow-derived mesenchymal stem cells (BM-MSC) migrate to primary tumors and drive tumor progression. This study aimed to identify the molecular mechanisms associated with these heterotypic cellular interactions and analyse their relevance in colorectal cancer (CRC). Design: Paracrine interactions of BM-MSC with CRC cells were studied using collagen invasion assays, cell counts, flow cytometric cell-cycle analysis and tumor xenograft models. The role of neuregulin 1 (NRG1) and the human epidermal growth factor receptor (HER) family pathways were investigated using tyrosine kinase assays, mass spectrometry, pharmacological inhibition, antibody-mediated neutralisation and RNA interference. Transmembrane NRG1 (tNRG1), HER2 and HER3 expression was analysed in primary CRCs (n = 54), adjacent normal colorectal tissues (n = 4), liver metastases (n = 3) and adjacent normal liver tissues (n = 3) by immunohistochemistry. Results: BM-MSC stimulate invasion, survival and tumorigenesis of CRCs through release of soluble NRG1, activating the HER2/HER3-dependent PI3K/AKT signaling cascade in CRC cells. Tumor-associated mesenchymal cells (T-MC) in CRCs demonstrate high tNRG1 expression. HER2 and HER3 show membrane localization in cancer cells of CRC tissue. High tNRG1 expression in T-MC is significantly associated with advanced UICC stage (P = .005) and invasion depth (P = .04) and decreased 5-year progression-free-survival (PFS) (P = .01). Conclusion: Paracrine NRG1/HER3 signals initiated by BM-MSC promote CRC cell progression, and high tNRG1 expression is associated with poor prognosis. Citation Format: Olivier De Wever, Astrid De Boeck, An Hendrix, Hannelore Denys, Geert Braems, Marc Bracke. Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signaling. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2602. doi:10.1158/1538-7445.AM2013-2602
Abnormalities of platelet function in the myeloproliferative disorders
Authors: J. M. Cardamone
Journal: JAMA (1972)

Despite extensive investigation of all aspects of the coagulation system, the mechanisms underlying the hemorrhagic and thrombotic complications seen in the "myeloproliferative disorders" have not been satisfactorily elucidated. In an attempt to define the abnormality underlying the hemorrhagic diathesis, the platelet function of 21 consecutive patients admitted to the University of Minnesota Hospitals with various myeloproliferative disorders (polycythemia vera, myelogenous leukemia, agnogenic myeloid metaplasia, and erythroleukemia) was evaluated by the use of both the older, less sensitive methods, and those more sensitive and reliable techniques which have recently become available. All 21 patients demonstrated some degree of platelet function abnormality, which was more severe in those patients with clinically apparent bleeding diatheses. Two illustrative cases point out the therapeutic approaches which are currently available to control the hemorrhagic problems occurring in these patients as a consequence of their abnormal platelet functions.
Highlights
Journal: JAMA (2014)

Telecare Collaborative Management of Chronic Pain 240Pain is a common problem among primary care patients, and evidence-based, primary care interventions for chronic pain are needed.Kroenke and colleagues assessed the efficacy of a telephone-delivered collaborative care (telecare) pain management intervention in a randomized trial involving 250 patients with chronic musculoskeletal pain.The authors report that compared with usual care, the telecare intervention, which included automated symptom monitoring and an algorithm-guided stepped care approach to optimizing analgesics, increased the proportion of patients whose pain improved.In an Editorial, Ohl and Rosenthal discuss telecare management of chronic pain.
Role of the template bleeding time in predicting bleeding complications of percutaneous liver biopsy . 1Mount Sinai Medical Center, New York, NY and 2University of Cincinnati Medical Center, Cincinnati, OH
Journal: Hepatology (1995)

To determine the effectiveness of augmenting T-tube cholangiography by using intravenous morphine in orthotopic liver transplant recipients with choledocho-choledochostomies and poor filling of intrahepatic biliary ducts and to determine factors that may increase the likelihood of nonfilling of intrahepatic ducts.A retrospective review of T-tube cholangiograms obtained in orthotopic liver transplant recipients was performed. Intravenous morphine had been given by two of five operators to augment T-tube cholangiograms with poor filling of bile ducts. Patients with malpositioned tubes and decompressive bile leaks were excluded from morphine diagnostic efficacy evaluation but were included in the overall cholangiogram diagnostic yield. Anastomotic narrowing, if present, was graded as follows: >50%, 20%–50%, and <20% diameter reduction. Patients with intrahepatic bile duct filling were compared to those without filling with regard to age, sex, time from transplantation, and clinically significant (>50%) stenoses.One hundred sixty-eight cholangiograms were obtained in 127 recipients. Twenty-three of the 168 cholangiograms (13.7%) had malpositioned/blocked T-tubes and five (3%) had decompressive leaks; 140 cholangiograms had well-positioned tubes and no leaks. Twenty-two of the 140 cholangiograms with well-positioned tubes and no leaks (15.7%) had nonfilling of peripheral bile ducts. Morphine (range, 2–6 mg; mean, 4 mg) had been used in 13 cases. Adequate filling after morphine was noted in 12 of the 13 cases (92%), and no complications occurred. Morphine improved adequate diagnostic examination of well-positioned patent T-tubes from 85% (123/145) to 93% (135/145). No parameters helped predict inadequate filling in well-positioned tubes (P > .05).In 92% of cases, intravenous morphine was successful in opacifying the biliary tract without complications. In well-positioned T-tubes, the use of morphine increased diagnostic yield from 85% to 93%. No predictors for inadequate filling were found.
Anaesthetic Contamination
Authors: T. H. S. Burns
Journal: BMJ (1973)

of dealing with the problem of anaesthetic contamination.This venting system has been in use for over six monthes in two operating theatres.Although the whole problem of operating theatre pollution seems to merit further in- vestigation, it is clear that until such time as the agent causing the possible deleterious effect on operating theatre personnel is identified all the anaesthetic gases and vapours should be vented from the operating room.-Iam, etc.
Depression and Survival Following Myocardial Infarction
Authors: Ton J. M. Cleophas
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The data of Frasure-Smith et al<sup>1</sup>identifying mental depression as a major determinant of cardiac death after MI are very impressive and will no doubt have a large impact. However, I have three points. First, the study found a fivefold higher mortality rate among depressed MI survivors. I think that this study may suffer from some selection bias. The two groups were tested for symmetry of covariates. However, their psychosocial factors before the MI were not taken into account and were probably largely asymmetric. I assume that many of the patients who were depressed after the MI were so before, and that their depression was, in fact, so severe that it led to the MI in the first place. Therefore, these are a selected group of severely depressed people and their mortality rates may not be representative for mortality rates of survivors of MI who were
Mutation profiling and treatment choosing of Chinese RET positive advanced lung cancer patients.
Authors: Jun Zhao, Qin Li, Gen Lin, Fei Ma, Qiong Zhao, Rongrong Chen, Ling Yang, Xuefeng Xia
Journal: Journal of Clinical Oncology (2018)

e21139 Background: RET is one of the rare driver genes in lung cancer, especially in NSCLC. In this study, we performed mutation profiling and treatment choice follow-up in Chinese advanced lung cancer patients. Methods: A total of 2755 advanced lung cancer patients were enrolled in this study, all samples were analyzed by next-generation sequencing across 59 genes based ER-Seq method, which enables simultaneously assess single-nucleotide variants, insertions/deletions, rearrangements, and somatic copy-number alterations. Results: Mutation profiling was possible for all patients, RET rearrangements were detected in 36 patients (1.3%). Of these 36 RET+ patients, the median age was 53(range 27-86); 42% were female. The most common histologies were NSCLC (78%) and LMAC (6%). Interestingly, a SCLC patient has also been identified as RET+, which has not been reported before. RET rearrangement occured in all these patients, predominantly fused with KIF5B (67%) and CCDC6 (25%), with ANK, ERC1 and NCOA1 followed. ANK-RET and ERC1-RET were commonly founded in thyroid carcinoma or breast cancer, and rare in NSCLC. 4 patients coexist with EGFR mutations, were all resulting in EGFR-TKIs treatment. For treatments, 33% patients chose RET inhibitors, another 14% patients chose chemotherapy or chemoradiotherapy. Of the 13 patients never been treated, 31% (4/13) accepted RET inhibitors and received ORR 75%. Conclusions: RET fusion mutation has complex heterogeneity, target NGS profiling is a available tool that can detected rare fusion types, may provide insight into heterogeneity. There is still much room for growth for RET inhibitors in Chinese advanced lung cancer.