tbuckley/cabot-search huggingface dataset:
Abstract 3556: Diabetic Cardiac and Renal Complications are attenuated in Mice with Conditional Knockout of Endothelin-1 in Vascular Endothelial Cell
Authors: Bambang Widyantoro, Suko Adiarto, Naoko Iwasa, Kazuhiko Nakayama, Dyah W Anggrahini, Kazuya Miyagawa, Hidemi Nonaka, Takashi Suzuki, Yaz Y Kisanuki, Masashi Yanagisawa, Noriaki Emoto
Journal: Circulation (2007)

High plasma endothelin-1 (ET-1) level has been associated with diabetic cardiovascular and renal complications, which remained prevalent despite good glycemic control. Since endothelial dysfunction, which is characterized by enhanced ET-1 secretion, plays an important role in mediating diabetic complication, we hypothesized that disruption of ET-1 in endothelial cell will be protective against cardiac and renal complication of diabetes. To test this hypothesis, we injected streptozotocin to Vascular Endothelial cell Specific Endothelin-1 Knockout (VEETKO) mice, of which ET-1 expression in major organs including heart and kidney were reduced by 60%, and to their wild type (WT) littermates. Six months of diabetes increased systolic blood pressure (SBP) similarly in both genotypes, with DM-VEETKO mice have remained lower SBP than DM-WT mice (124±1.08 vs. 131.33±1.33 mmHg, p&lt;0.01, n=8 each). Diabetes also exaggerated the difference in cardiac ET-1 mRNA expression between both groups. The heart of DM-VEETKO mice showed lower area of interstitial fibrosis as compared to DM-WT mice, and this is associated with lower expression of fibrotic genes (TGF-β, CTGF and Collagen-1), higher capillary density (as measured by CD-31 staining) and higher VEGF mRNA expression. Furthermore, eight months of diabetes decreased cardiac systolic function of all mice, however, the decrease is significantly attenuated in DM-VEETKO mice (fractional shortening 45.67±0.61 vs. 38.27±2.2%, p&lt;0.01, n=4 each). Similarly, DM-VEETKO mice also preserved renal function. Diabetes caused an increase in urinary protein excretion with the values in DM-VEETKO mice being approximately one fifth of DM-WT mice (30.12±10.09 vs. 170±23.19 mg/dl, p&lt;0.01, n=6 each) Morphologically, DM-VEETKO mice have less glomerular fibrosis which is associated with lower expression of ICAM-1, and further leads to lower glomerular macrophage recruitment. In conclusion, these findings indicate that disruption of ET-1 in endothelial cell is significantly attenuated diabetic cardiovascular and renal complication in streptozotocin-induced diabetic mice model, and may provide additional basic rationales for the use of ET-1 blockade for the prevention of cardiac and renal complication of diabetes.
Error in Payments From Some Pharmaceutical Companies
Journal: JAMA Network Open (2019)

In the Original Investigation titled "Payments From Pharmaceutical Companies to Authors Involved in the Valsartan Scandal in Japan," 1 published May 17, 2019, payments from some pharmaceutical companies were double-counted.A complete itemization of corrections is as follows: (1) the number of authors who received payments and the percentage of payments accounted for by corresponding authors in the Key Points; (2) the number of authors who received payments, the percentage of payments accounted for by corresponding authors, and the payment value in the abstract; (3) the number of authors who received payments, the percentage of payments accounted for by corresponding authors, and the payment value in the Results section; (4) the percentage of authors who received payments, the percentage of payments accounted for by corresponding authors, and the payment value in the Discussion section; (5) the number of authors who received payments in the Conclusions section; (6) the payment value and the number of authors who received payments in Table 2; and (7) the payment value and the number of authors who received payments in Table 3.
Letting go of the bear's tail. Experience with discontinuation of long-term anticoagulant therapy
Authors: R. B. Van Cleve
Journal: JAMA (1966)

LONG-TERM anticoagulant therapy has been used for many years in conditions such as myocardial infarction in which there is a risk of thromboembolism. Several reports have questioned the usefulness of anticoagulants in preventing a recurrence of myocardial infarction.<sup>1-5</sup>Other studies have cast some doubt on the necessity of continuing such treatment for longer than a year following the infarction.<sup>6-8</sup> There is also considerable controversy regarding the recurrence of thromboembolic episodes following discontinuation of long-term anticoagulant therapy. Our experience with abrupt discontinuation of long-term anticoagulant therapy has been published elsewhere.<sup>9</sup>This paper concerns 149 patients whose long-term therapy with sodium warfarin (Coumadin Sodium) was discontinued and compares them to those whose anticoagulant therapy was continued in an effort to see if all patients should be maintained on this therapy indefinitely. <h3>Description of the Study</h3> A total of 191 patients who had been receiving sodium warfarin for an average
Die allgemeinen pathomorphologischen Grundlagen der Tuberkulose.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatitis B core-related antigen and viral loads status impacts on the risk of hepatocellular carcinoma in patients with HBeAg-negative chronic hepatitis B virus infection
Authors: Tetsuya Hosaka, Fumitaka Suzuki, Masahiro Kobayashi, Shunichirou Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Norio Akuta, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Hiromitsu Kumada
Journal: Journal of Hepatology (2020)
New insights into the mechanism of bile acid?induced biliary lipid secretion*1
Authors: H VERKADE
Journal: Hepatology (1995)

Polygonum multiflorum Thunb (Heshouwu, HSW) is commonly used in clinical medicine, while the hepatotoxicities of HSW are reported increasingly in recent years. Currently, researchers have demonstrated an essential role of Bile Acids (BAs) in liver diseases. The occurrence of hepatotoxicity cases linked to HSW are characterized by jaundice and cholestasis, suggesting an interaction that between BAs and HSWThis study was designed to investigate the HSW-induced liver functional and histological changes in mice and the role of HSW on bile acid synthesis, metabolism, clearance and intestinal absorption.The mice were intragastrically (i.g.) given HSW at doses of 1.275 and 3.825 g/kg (Crude extracts /body weight) once a day for seven days. Liver function was evaluated by measuring the serum levels of enzymes and analyzing the liver histology. The LC/MS analysis was performed to quantify BAs from liver, ileum and serum. Moreover, the expression of bile metabolic-related transporters and metabolic enzymes at both protein and mRNA levels were observed to elucidate the underlying mechanisms.Oral administration of HSW for 7 days could not cause liver damage. A significant change was observed for the concentrations of liver and serum BAs in treatment groups compared with normal control. The mRNA expression levels of bile acid excretory transporter (Bsep) and basolateral uptake transporter (Ntcp) were increased with the development of HSW. The concentrations of unconjugated BAs increased in mice intestines after the administration of HSW. Western blot and qRT-PCR analyses showed that HSW upregulated the protein and mRNA expression of Shp and Fgf15 in the ileum of the mice.HSW treatment for 7days did not cause liver damage. HSW accelerated bile acid enterohepatic circulation and changed the composition of intestinal BAs, leding to the activation of Fxr-Fgf15 signal in intestines, and further inhibited the expression of Cyp7a1 in the liver.
Massachusetts Medical Society
Authors: Donald Glicklich
Journal: New England Journal of Medicine (1958)

TOXIC HAZARDS*Salicylate Poisoning — I.†Salicylate poisoning continues to be a major hazard to infants and children and a challenge to the medical profession. Of the 486 accidental poisonings treated in the emergency clinic of the Children's Medical Center, Boston, in the two-year period, 1956–1957, 146 (30 per cent) were from salicylates. Seventeen per cent of the reported deaths from accidental poisoning in children under five years of age in the United States during 1956 were due to salicylates, a cause second only to petroleum products. The following recent case is reported from the Children's Medical Center, to emphasize . . .
Corrigendum
Journal: BMJ (1938)

are made up of normal movements, carefully thought out to avoid muscular over-development and strain and to develop control, strength.and grace.Repose, relaxation, and rhythm are considered to be of great importance, all of which are necessarv to counteract the effects of modern living.This form of exercise should be of benefit to any type of person, especially to neurotic subjects, as it possesses so much rhythm and teaches the expression of individuality.The classes are graded to suit both the mental and physical ability of pupils, and all the teachers are people of education and culture with a knowledge of anatomy.
PASSAGE OF TUBERCLE BACILLI FROM THE INTESTINE INTO THE CHYLE VESSELS AND THORACIC DUCT.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heredity, Food, and Environment in the Nutrition of Infants and Children
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
2020 SCCT Guideline for Training Cardiology and Radiology Trainees as Independent Practitioners (Level II) and Advanced Practitioners (Level III) in Cardiovascular Computed Tomography: A Statement from the Society of Cardiovascular Computed Tomography
Authors: Andrew D. Choi, Dustin M. Thomas, James Lee, Suhny Abbara, Ricardo C. Cury, Jonathon A. Leipsic, Christopher Maroules, Prashant Nagpal, Michael L. Steigner, Dee Dee Wang, Michelle C. Williams, Irfan Zeb, Todd C. Villines, Ron Blankstein
Journal: JACC. Cardiovascular imaging (2020)
Temporal and geographical variations in the prevalence of primary biliary cirrhosis (PBC) in North East England . Departments of Medicine and Epidemiology*, University of Newcastle, Newcastle upon Tyne, United Kingdom
Journal: Hepatology (1995)

Choosing an appropriate retention system for patients with partial edentulism and dental implants is impeded by a paucity of evidence. The available evidence is extrapolated from either completely edentulous or mixed study populations.The purpose of this systematic review was to assess the effects of different retention systems used for implant-supported prostheses in patients with partially edentulous jaws by measuring the rates of failure, survival, and event-free situations.An electronic database search supplemented by a manual search was conducted to identify the best, good, and fair quality studies reporting at least 10 participants with a 1-year follow-up (PROSPERO-CRD 42015024649). Summary estimates of the survival, failure, and event-free proportions were obtained using a random effects model with a 95% confidence interval.Among the 896 citations from 3875 titles identified by the search, 104 studies reporting over 5317 participants with 9568 reconstructions and a total exposure time of 46 553.18 years were included in the analysis. Screw-retained single crowns showed twofold minor complication even rates (8.5%; 95% confidence interval [CI]: 5.5-12.9) compared with cement-retained single crowns (4.2%. 95% CI; 3.2-5.4). None of the retention systems were more advantageous than the others in relation to failure and event-free outcomes. However, the summary of the findings suggests that cement-retained single crowns, splinted crowns, and cantilever-fixed partial dentures performed better (with fewer events) than screw-retained restorations in the long term.Results suggest that cement retention may be an appropriate system for implant-supported restorations in partial edentulism. However, high-quality prospective studies and cost evaluation are recommended to confirm the evidence.
HbS/βdel‐thalassemia associated with high levels of hemoglobins A2 and F in a Turkish family
Authors: G.O. Tadmouri, L. Yüksel, A.N. Başak
Journal: American Journal of Hematology (1998)

β-thalassemia and sickle cell disease (SCD) are common disorders in Turkey. Compound heterozygosity for these two disorders (βS/β-thalassemia) is encountered frequently. In this report we present hematological and molecular data of two Turkish siblings with βS/βdel-thalassemia caused by a 290 base pair (bp) deletion and associated with increased levels of hemoglobin A2 (HbA2) and hemoglobin F (HbF). Clinical analysis of the two patients showed a mild course of the disease. Haplotypic factors involved in increasing the levels of HbF were analyzed. The two patients showed no changes from the normal sequences at the XmnI site of Gγ-globin promoter and the (AT)xTy microsatellite 5′ to the β-globin mRNA cap site. The removal of the region between positions −125 to +78 relative to the β-globin gene mRNA cap site by the 290 bp deletion is thought to allow the β-locus control region to interact with the promoters of the δ- and γ-globin genes, leading to increased HbA2 and HbF levels. Am. J. Hematol. 59:83–86, 1998. © 1998 Wiley-Liss, Inc.
Closure of peritoneum
Authors: T. E. Elliott
Journal: JAMA (1979)

<h3>To the Editor.—</h3> I recently read the article by Joe G. Hardin, MD (240:1889,1978), in which he described a man with long-standing Still's disease and a<i>Proteus mirabilis</i>arthritis of the hip. Despite appropriate antibiotic therapy and no symptoms suggestive of a continued pyarthrosis, he still had the same organism in the hip six months later at the time of a successful joint replacement. Hardin stated that this patient, who was receiving indomethacin therapy for rheumatoid arthritis, showed no gross signs of infection at surgery. Furthermore, the patient had been clinically well, experiencing only a degree of hip pain compatible with mechanical joint dysfunction. Hardin believed that a Gram-negative bacillary arthritis of this duration, with these few clinical expressions and relatively benign histopathologic signs, had not, to his knowledge, been previously recognized. He hypothesized that this patient's course might be peculiar to infection with<i>P mirabilis</i>and suggested that in
THE SIGNIFICANCE OF INFECTION, HEREDITY AND PREDISPOSITION IN THE DEVELOPMENT OF PULMONARY TUBERCULOSIS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short-Term Effect of Psychotropic Drugs on Platelets
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nonpenetrating Traumatic Injury of the Aorta
Authors: LOREN F. PARMLEY, THOMAS W. MATTINGLY, WILLIAM C. MANION, EDWARD J. JAHNKE
Journal: Circulation (1958)

Rupture or laceration of the aorta is a more common result of nonpenetrating traumatic injury than is generally appreciated. Approximately 15 per cent of individuals with traumatic rupture survive temporarily. If the lesion is promptly diagnosed appropriate surgical treatment may be life-saving. Diagnosis may be difficult and at times the rupture may remain clinically silent for variable periods. The natural course from aortic rupture to false aneurysm formation with secondary rupture of the aneurysm may be brief or extend over many years. Surgical treatment of a false aneurysm that has remained stable for a prolonged period has been successful, but in some instances conservative management may be the treatment of choice.
Evaluating vitamin prophylaxis for cancer
Authors: Kathryn Simmons
Journal: JAMA (1986)

It's been four years since the National Cancer Institute (NCI) formally announced that it was launching a long-range cancer chemoprevention program. Since then, the institute has launched 26 clinical trials, and backed them with about $27 million in funding annually. The designs—and preliminary results—of some of these trials were presented in Tucson at the Second International Conference on the Modulation and Mediation of Cancer by Vitamins and Micronutrients. Peter Greenwald, MD, director of the NCI's Division of Cancer Prevention and Control, Bethesda, Md, characterized the program in a keynote address: "I think for the first time we have investigators from many different disciplines who are working hard at it [and are] working together. We have testable hypotheses that are very plausible. We have clinical trials in progress in cancer prevention, and they're augmented by a lot of basic research studies of the biochemistry." The program is designed to evaluate the
In Reply:
Authors: Per Eystein Lønning, Jurgen Geisler
Journal: Journal of Clinical Oncology (2005)

not greater than 2.14% per year (5% confidence on values above 2.14, 90% on values between 0.34 and 2.14, and 5% on values below 0.34) or 4.28% over two years (changes that are not considered clinically meaningful).Thus, our conclusion, based on the Lønning data, is that the jury is still out on whether exemestane causes bone loss.This important issue may be clarified by ongoing trials, such as the National Cancer Institute of Canada Clinical Trials Group MA 27 clinical trial, which has a specific bone substudy to compare the bone effects of exemestane to those of anastrozole in women with early stage breast cancer.