OXYGEN THERAPY
Authors: RICHARD W. HYDE
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 September 1969OXYGEN THERAPYRICHARD W. HYDE, M.D., ARON B. FISHER, M.D.RICHARD W. HYDE, M.D.Search for more papers by this author, ARON B. FISHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-3-665 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Dr. Petty's recent editorial note, "Misunderstanding Concerning the Proper Clinical Use of Oxygen," gives sound advice for the application of oxygen therapy in most clinical situations (1). However, the plea for the prolonged use of oxygen concentrations as high as 100% in patients with profound respiratory distress due to hypoxemia requires amplification. Many authors have pointed out that the administration of 100% oxygen for periods in excess of 24 hr will almost inevitably lead to progressive pulmonary insufficiency, severe hypoxia, and death (2). An increasing number of reports are being published describing this course of events in...References1. PETTY TL: Misunderstndings concerning the proper clinical use of oxygen. Ann. Intern. Med. 70: 645, 1969. LinkGoogle Scholar2. LAMBERTSEN CJ: Effects of oxygen at high partial pressure, in Handbook of Physiology. Section 3, Vol. II, American Physiological Society, Washington, D. C., 1965, p. 1027. Google Scholar3. NASHBLENNERHASSETTPONTOPPIDAN GJBH: Pulmonary lesions associated with oxygen therapy and artificial ventilation. New Eng. J. Med. 276: 368, 1967. CrossrefMedlineGoogle Scholar4. CASTLEMAN B (Editor: Case record of the Massachusetts General Hospital. Case 7-1967. New Eng. J. Med. 276: 401, 1967. CrossrefMedlineGoogle Scholar5. HYDERAWSON RWAJ: Oxygen pneumonitis in man. Response to therapy (abstract). Clin. Res. 16: 561, 1968. Google Scholar6. WINTERGAPTAMICHALSKILANPHIER PMRKAEH: Modification of hyperbaric oxygen toxicity by experimental venous admixture. J. Appl. Physiol. 23: 954, 1967. CrossrefMedlineGoogle Scholar7. MILLER WW: Pulmonary O2 toxicity: comparison in cyanotic and acyanotic dogs. Transactions of the XIIth International Congress of Pediatrics. In press. Google Scholar8. FAIRLEY HB: The oxygen tightrope. Can. Anaes. Soc. J. 13: 98, 1966. CrossrefGoogle Scholar9. SLADENLAVERPONTOPPIDAN AMBH: Pulmonary complications and water retention in prolonged mechanical ventilation. New Eng. J. Med. 279: 448, 1968. CrossrefMedlineGoogle Scholar1. ASHBAUGHBIGELOWPETTYLEVINE DGDBTLBE: Acute respiratory distress in adults. Lancet 2: 319, 1967. CrossrefMedlineGoogle Scholar2. HARRISGRAYPETTYMUELLER TMMTLRE: Monitoring inspired oxygen pressures during mechanical ventilation. JAMA 206: 2885, 1968. CrossrefMedlineGoogle Scholar3. ASHBAUGHPETTYBIGELOWHARRIS DGTLDBTM: Continuous positive pressure breathing (CPPB) in adult respiratory distress syndrome. J. Cardiovas. Thorac. Surg. 57: 33, 1969. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Physiology (Graduate Division) and Medicine University of Pennsylvania Medical School Philadelphia, Pa. 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNeed for 100 Per Cent Oxygen Therapy 1 September 1969Volume 71, Issue 3Page: 665-667KeywordsAttentionHypoxiaOxygen Issue Published: 1 September 1969 PDF DownloadLoading ...