tbuckley/cabot-search huggingface dataset:
WASHINGTONL LETTER.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Resumption of female reproductive function following renal transplantation
Authors: I. R. Merkatz
Journal: JAMA (1971)

Menstrual patterns and fertility were studied in 27 renal transplant survivors aged 13 to 39 years. Amenorrhea was present before transplant in 26 women. Recovery of regular menses correlated with the level of renal function and the frequency and severity of rejection episodes. Five pregnancies occurred in four patients. All of these patients were delivered successfully of healthy babies in the face of unaltered immunosuppressive therapy. Vaginal delivery was feasible in three instances, but obstruction of the fetal head by the graft necessitated cesarean section in two women. Renal function declined in the third trimester in most cases, but returned promptly to normal after delivery. Determination of urinary estriol levels and combined intravenous pyelography and x-ray pelvimetry aided in the management of the pregnancies. Graft-directed antibodies were not induced by the fetuses in the cases studied.
Implications for health care policy. A social and demographic profile of hemodialysis patients in the United States
Authors: R. W. Evans
Journal: JAMA (1981)

Before 1973, selection of patients with end-stage renal disease (ESRD) for treatment was necessary because of inadequate medical and financial resources. Patients were selected based partly on social worth rather than medical suitability. In 1973 ESRD patients became eligible for Medicare benefits, eliminating the financial barrier to treatment. Using data from two national surveys of hemodialysis patients in 1967 and 1978, two social and demographic profiles of patients illustrate the effect of extension of Medicare benefits on composition of the dialysis patient population. These data indicate that problems of patient selection have been resolved, and ESRD patients now have equal access to medical care. Nevertheless, there is growing pressure for cost efficiency for the ESRD program in the tightening economic climate. This may lead again to some form of restriction for future access to dialysis therapy. (<i>JAMA</i>1981;245:487-491)
APPENDICITIS IN FRANCE AND IN AMERICA.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum to: Effect of different seated positions on lung volume and oxygenation in acute respiratory distress syndrome
Authors: J. Dellamonica, N. Lerolle, C. Sargentini, S. Hubert, G. Beduneau, F. Di Marco, A. Mercat, J. L. Diehl, J. C. M. Richard, G. Bernardin, L. Brochard
Journal: Intensive Care Medicine (2013)
Outpatient Clinic
Authors: M J Schwaber
Journal: Annals of Internal Medicine (1996)

On Being a Doctor1 June 1996Outpatient ClinicMitchell J. Schwaber, MDMitchell J. Schwaber, MDHadassah University Hospital-Mount Scopus, Jerusalem 91240, IsraelSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-11-199606010-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “I think you'd better at least talk to her,” the nurse said as she opened the door to my clinic office.“Fine,” I replied, “When I finish with the patient I'm seeing now.”It was Monday afternoon and I was in my weekly outpatient clinic. Every week patients come from around the city to my “cardiology” clinic. The fact that I am not a cardiologist but only a medical resident who sits next door to the cardiologist in clinic and consults with him when necessary does not seem to bother the patients, nor, for that matter, the primary care physicians ... Author, Article, and Disclosure InformationAuthors: Mitchell J. Schwaber, MDAffiliations: Hadassah University Hospital-Mount Scopus, Jerusalem 91240, IsraelCorresponding Author: Mitchell J. Schwaber, MD, Department of Medicine, Hadassah University Hospital-Mount Scopus, PO Box 24035, Jerusalem 91240, Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRussian–American health care: Bridging the communication gap between physicians and patients 1 June 1996Volume 124, Issue 11Page: 1012-1013KeywordsChartsElderlyEmotionsHeartHypertensionNursesOutpatient clinicsThoracic surgeryVisionWalking ePublished: 15 August 2000 Issue Published: 1 June 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Arctic Anemia
Authors: Robert W. Christie
Journal: New England Journal of Medicine (1958)

ANEMIA unexpectedly occurred in all 6 members of an expedition conducting a scientific exploration of the central Greenland Ice Cap in the spring and summer of 1955.1 This unusual response in the blood was revealed by weekly measurements of hemoglobin and red cells in the peripheral blood of each expedition member over a period of three and a half months. During this period all members were being subjected to hard physical exercise, low temperatures, moderately high altitudes and continuous daylight.The group was composed of white males under thirty-one years of age, none of whom were of Mediterranean ancestry, and . . .
Sarcoidosis
Authors: Michael C. Iannuzzi, Benjamin A. Rybicki, Alvin S. Teirstein
Journal: New England Journal of Medicine (2007)

Sarcoidosis affects people of all racial and ethnic groups and occurs at any age, although usually before the age of 50 years. The incidence of sarcoidosis varies widely throughout the world, probably because of differences in environmental exposures, case-surveillance methods, and predisposing HLA alleles, along with other genetic factors. This article summarizes advances in our understanding of sarcoidosis and addresses pitfalls in its diagnosis and treatment.
Crèvecoeur
Authors: Michelle M. Kittleson
Journal: Annals of Internal Medicine (2020)

Ad Libitum1 September 2020CrèvecoeurMichelle M. Kittleson, MD, PhDMichelle M. Kittleson, MD, PhDSmidt Heart Institute, Cedars-Sinai, Los Angeles, California (M.M.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-2145 Audio Reading - “Crèvecoeur” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Crèvecoeur” by Michelle M. Kittleson, MD, PhD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I remember whenWe met. You were suspicious;I, eager to please.I resolved to proveDespite (because of) my sex,I was competent.Separated byGenerations and culturesI did not blame you.You came to trust me.I guided, you listened: valveRepair, then transplant.Steroids made you soCranky. Your wife rolled her eyes,Annoyed, but smiled.I was your favorite.You requested me for allYour angiograms.The weeks turned to monthsTo years and we shared milestones:My kids, your grandkids.But today, I didNot recognize the confused,Frail man before me.What had six months wrought?Your wife wrung her hands and triedTo smile through her tears.We used to ... Author, Article, and Disclosure InformationAffiliations: Smidt Heart Institute, Cedars-Sinai, Los Angeles, California (M.M.K.)Current Author Address: Michelle M. Kittleson, MD, PhD, 8536 Wilshire Boulevard, Suite 301, Los Angeles, CA 90211; e-mail, michelle.[email protected]org. PreviousarticleNextarticle Advertisement Audio Reading - “Crèvecoeur” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Crèvecoeur” by Michelle M. Kittleson, MD, PhD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 1 September 2020Volume 173, Issue 5Page: 400KeywordsAngiographyHeartSteroids ePublished: 1 September 2020 Issue Published: 1 September 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Staying is harder than getting there
Authors: W. R. Barclay
Journal: JAMA (1978)

Regular exercise that improves general physical fitness may lessen the risk of a heart attack and may increase one's capability of dealing with illness should it occur. Therefore, although a desk-bound editor, I elected to engage in a program of physical conditioning, and from the many programs widely publicized, selected that recommended by Kenneth H. Cooper.<sup>1</sup>Jogging in the early morning was pleasant during the summer, and the anticipation of reaching a goal, modestly set at a 3-km run each morning in 17 minutes, made the effort seem easy and worthwhile. Friends and family remarked on my improved appearance, I felt fitter and more energetic, and having reached the preset goal, I felt some smug satisfaction. However, the lovely summer mornings gave way to the dark, cold, and wet mornings of late fall, and the realization finally dawned that in pursuing a goal, it is much harder to stay than
Evaluation of the public health risks associated with semivolatile metal and dioxin emissions from hazardous waste incinerators.
Authors: R M Sedman, J R Esparza
Journal: Environmental Health Perspectives (1991)

The public health impacts associated with stack emissions from hazardous waste incinerators have become a major concern in recent years. Most evaluations of incinerator stack emissions have focused on three classes of compounds: metals, semivolatile, and volatile compounds. These investigations have been complicated by the difficulty and expense of analyzing the emissions and the limited amount of toxicity information for many of the compounds that have been detected. The results of over 20 trial burns at hazardous waste incinerators were assembled in an attempt to determine which compounds may pose a significant threat to the public health. The risks associated with semivolatile emissions were found to be inconsequential, although further study of dioxins and dibenzofurans emissions appears to be warranted. The risk associated with the emission of cadmium and perhaps chromium (VI) may pose a significant risk to public health at certain facilities. Controls on waste feed or air pollution control devices should be employed to reduce the emission of these metals. Any monitoring of metal emissions from hazardous waste incinerators should focus on cadmium and chromium (VI).
Resident's attitudes and beliefs towards palliative care in a community teaching hospital.
Authors: Sufana Shikdar, Noel Medeiros, Erin Kelly, Nicholas Ghionni, Deborah Cassidy, Asif abdul Hameed, Eric Green
Journal: Journal of Clinical Oncology (2018)

e22187 Background: Early integrated palliative care improves the quality of life in patients with cancer. Wong et al (2016) recently demonstrated that residents and fellows in a University Hospital-based large comprehensive cancer center believed palliative care services to be beneficial for patient care. However, there are substantial differences between the clinical learning environments of a University and Community Teaching Hospital. We aim to assess resident’s attitudes and beliefs towards palliative care in the oncologic population in a community teaching hospital. Methods: We surveyed all residents(n = 90) in a Mercy Catholic Medical Center's internal medicine, transitional year, and general surgery residencies about their knowledge, training, attitudes and beliefs regarding palliative care using a survey modified from Wong et al (2015). Mercy Catholic Medical Center is a conglomeration of two community teaching hospitals in greater Philadelphia. The factors associated with awareness were analyzed using chi square or fisher exact test and logistic regression. Results: A total of 57 (63%) residents participated. The differences between the knowledge of residents from other specialties were not statistically significant. The awareness was reported more among residents who are American medical graduates (P = 0.03). The majority of the residents believed palliative care was beneficial to patients and families (98%), reduce health care costs (91%), decrease overall symptom burden (86%) and symptomatic management in newly diagnosed cancer (81%). Residents who reported having palliative care training during residency had significantly higher awareness (OR = 2.99, P = 0.04). Conclusions: Our study shows that the attitude and belief of residents at community teaching hospital is similar to the trainees at university teaching hospital. The implementation of palliative care rotation for all residents from clinical specialties can be effective in improving trainee’s attitude and belief regarding increased and early referral to palliative care.
New England Journal of Medicine, Boston
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Answer
Authors: H Yoshida, R Tateishi, Y Arakawa, M Sata, S Fujiyama, S Nishiguchi, H Ishibashi, Y Shiratori, M Omata
Journal: Gut (2004)

Background: An increase in the incidence of hepatocellular carcinoma (HCC) in Japan since the 1980s suggests an imminent outbreak in other countries where viral spread occurred more recently.Interferon therapy for chronic hepatitis C, in general, has been shown to prevent HCC.Aims: To determine the scale of benefit in individual patients.Subjects: Histologically proven chronic hepatitis C patients in the Inhibition of Hepatocarcinogenesis by Interferon Therapy (IHIT) cohort (Ann Intern Med 1999;131:174), as updated in March 2003.Methods: The lifetime risk for HCC was calculated based on HCC incidence rates, stratified by sex, age, fibrosis stage, and outcome of interferon therapy.The gain in HCC free survival was defined as the difference between expected HCC free survival with sustained virological response and that without.Results: The gain in HCC free survival was greater when a patient was younger and fibrosis was more advanced.For example, a 30 year old male with F3 fibrosis gained 12.4 years by attaining sustained response while a patient with F1 fibrosis older than 60 years gained less than one year.For a treatment protocol with a given sustained response rate, prior estimation of the gain can be obtained by multiplying the calculated HCC free survival for responders by the response rate.Conclusions: The gain in HCC free survival may serve as an indicator of the benefit of interferon therapy in terms of HCC prevention and be useful in the consideration of indication and selection of treatment protocol for individual patients.. . . . . .
Abstract 1347: Peripheral blood TCRB chain convergence in chronic viral infection and cancer: Emerging trends from a novel immune repertoire biomarker
Authors: Timothy J. Looney
Journal: Cancer Research (2019)

Abstract Background T cell receptor (TCR) convergence refers to the phenomenon whereby antigen-driven selection enriches for TCRs having shared antigen specificity but different nucleotide sequences. Previous work has demonstrated the potential utility of TCR convergence as a predictive biomarker for response to checkpoint blockade and dendritic cell based immunotherapy for cancer. The extent to which convergence arises owing to chronic viral infection is not yet established. Here we sought to identify features of chronic cytomegalovirus (CMV) infection using TCRB profiling of peripheral blood (PBL) total RNA. Methods Total RNA from PBL was obtained from 35 blood donors of known CMV status, then used for TCRB sequencing via the Oncomine TCRB-LR assay (amplicon spanning CDR 1, 2 and 3) and the Ion Torrent S5. In parallel, we prepared libraries via the Oncomine TCRB-SR assay (CDR3 only). Data were used to identify TCRB repertoire features correlated with CMV status and compare repertoire features across the two assays. For context, we compare CMV-related convergence to previous reports detailing convergent T cell responses in individuals with cancer. Results T cell clone evenness was reduced in CMV positive individuals irrespective of age, predictive of CMV status (AUC=.86, p=2E-4, Wilcoxon), and strongly correlated between LR and SR assays (Spearman cor=.96). TCR convergence was elevated in CMV positive individuals and uncorrelated with evenness (Spearman cor = -.03) such that the combination of convergence and evenness improved the performance of a logistic regression classifier (AUC= .93). Conclusions We identify reduced T cell evenness and elevated TCR convergence as features of chronic CMV infection. CMV infection appears to significantly alter the T cell repertoire, suggesting that CMV status may be required for proper interpretation of T cell expansion in the context of immunotherapy for cancer. TCR convergence may detect T cell responses to a broad range of viral and tumor neoantigens and thus may serve as a particularly useful biomarker for the identification of immunogenic tumors having few genetic alterations. Citation Format: Timothy J. Looney. Peripheral blood TCRB chain convergence in chronic viral infection and cancer: Emerging trends from a novel immune repertoire biomarker [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1347.
Pharmacokinetics and Molecular Detoxication
Authors: John R. Cashman, Beatrice Y. T. Perotti, Clifford E. Berkman, Jing Lin
Journal: Environmental Health Perspectives (1996)

This paper presents a comprehensive overview of the pharmacokinetic parameters used from in vivo and in vitro studies that are important in order to understand the major conceptual approaches of toxicokinetics and the disposition of environmental chemicals.In vitro biochemical information concerning the detoxication of environmental chemicals is also presented.The discussion leads to a more complete appreciation for the use of in vitro measurements for in vivo correlations.The concept of interspecies scaling in the interpolation and extrapolation of fundamental biochemical metabolic processes is illustrated with a number of examples.Additional examples of in vitro-in vivo correlations are presented in the evaluation of the impact of chemical exposure to humans.Finally, several important metabolic detoxication enzymes are presented, including the mammalian microsomal cytochrome P450 and flavin-containing monooxygenases as well as carboxylesterases and glucuronosyltransferases, to provide insight into the processes of chemical detoxication in mammalian tissue and blood.Because interspecies scaling and the pharmacokinetics of chemical disposition have already shown their usefulness in understanding some examples of chemical disposition, our summary focuses on showing the usefulness of the pharmacokinetic equations and providing confidence in using the approach for in vitro-in vivo correlations.Ultimately, the presentation may provide the reader with a conceptual framework for future evaluation of the human health risks associated with environmental toxicants.
Risk of cancer mortality in populations living near nuclear facilities
Authors: G. R. Howe
Journal: JAMA (1991)

Studies of populations exposed to high levels of ionizing radiation, such as the survivors of the atomic bombings at Hiroshima and Nagasaki<sup>1</sup>and tuberculosis patients exposed to multiple chest fluoroscopies,<sup>2</sup>have clearly demonstrated that such exposures increase the risk of a number of cancers. This basic observation has inevitably raised public concern as to whether the normal operation of nuclear power facilities presents an increased risk of cancer to those who work in such facilities, or who are residents near them. This concern has been heightened by recent studies from the United Kingdom that have reported excess incidence of childhood leukemia in children living near several nuclear facilities, most notably a fuel reprocessing plant located at Sellafield in northwest England.<sup>3</sup> To estimate the cancer risks associated with exposure to low doses of radiation, the usual procedure is to extrapolate the results of high-dose studies, such as that