tbuckley/cabot-search huggingface dataset:
Psychology, History
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pregnancy during adjuvant chemotherapy for breast cancer
Authors: P. R. Jochimsen
Journal: JAMA (1981)

Two patients became pregnant while receiving adjuvant chemotherapy for breast cancer following mastectomy. These cases suggest that the significant prolongation of disease-free survival seen in young premenopausal patients may not be ascribable to ovarian failure alone. While the degree to which these patients will benefit from adjuvant therapy is unknown, it is clear that the agents used did not affect fertility. The need to instruct such patients in the necessity for using nonoral contraceptive techniques is stressed. (<i>JAMA</i>1981;245:1660-1661)
Contents: (Adv. Healthcare Mater. 1/2015)
Journal: Advanced Healthcare Materials (2015)

In the Best of HealthMicrofl uidic fi ber fabrication is an emerging strategy for generating synthetic tissue scaffolds and organized cell constructs.Core-sheath fl ow profi les are generated within a microchannel and solidifi cation of the core fl uid continuously produces a polymer microfi ber.This system is amenable to an array of polymer chemistries, material composites, and most importantly the incorporation and organization of fragile biomacromolecules and viable cell populations.
Comparison of Pesticides and Other Compounds in Carpet Dust Samples Collected from Used Vacuum Cleaner Bags and from a High-Volume Surface Sampler
Authors: Joanne S. Colt, Shelia H. Zahm, David E. Camann, Patricia Hartge
Journal: Environmental Health Perspectives (1998)

Epidemiologic studies of the association between residential pesticide use and cancer risk require an assessment of past pesticide exposures. Pesticide levels in carpet dust are believed to reflect long-term pesticide use. Recent epidemiologic studies have found collection of dust samples using the high-volume surface sampler (HVS3) to be expensive and cumbersome. We compared the levels of pesticides and other compounds in dust obtained from subjects' personal used vacuum cleaner bags to that collected by the HVS3 to see if this simpler method could replace the HVS3 in epidemiologic research. We visited the homes of 15 subjects, took the used bags from their vacuums, and collected carpet dust samples with the HVS3. The samples were analyzed for 42 target compounds: 26 pesticides, 10 polycyclic aromatic hydrocarbons (PAHs), and six polychlorinated biphenyl (PCB) congeners using GC/MS in selected ion monitoring mode. The two methods agreed in detecting the presence of the target compounds between 80% and 100% of the time. Neither sampling method was consistently more sensitive. The median target compound concentrations were similar, and a paired t-test showed no significant differences. For many compounds, the concentrations of compounds in the HVS3 samples were higher than those in the used bag samples at the upper end of the concentration ranges. However, the Spearman rank correlation coefficients were 0.85 or higher for most compounds, indicating that homes would be ranked similarly using both methods. Overall, there appears to be no clear difference in the quality of the pesticide, PAH, or PCB concentration data for the two dust collection methods.
Concurrent chemoradiotherapy of twice weekly paclitaxel and cisplatin followed by esophagectomy for locally advanced esophageal cancer
Authors: C.-H. Hsu, C.-C. Lin, K.-H. Yeh, J. C. Chen, L.-L. Ting, J.-M. Lee, Y.-C. Lee, H.-P. Wang, J.-T. Lin, A.-L. Cheng
Journal: Journal of Clinical Oncology (2004)

4033
Correction: Funding family health services
Journal: BMJ (1991)

considered to be appropriate use of the out of hours service.'2However, Usherwood has shown that written advice about particular childhood symptoms may increase out of hours visits.'3Other opportunities for advising mothers include paediatric assessment clinics, immunisation clinics, and routine surgery attendances.The health visitor is a valuable member of the team who is underused as a source of advice on the management of childhood illness'4-a finding confirmed by this study.
Drug and Opioid-Involved Overdose Deaths — United States, 2013–2017
Authors: Lawrence Scholl, Puja Seth, Mbabazi Kariisa, Nana Wilson, Grant Baldwin
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

In 2017, among 70,237 drug overdose deaths, 47,600 (67.8%) involved opioids, with increases across age groups, racial/ethnic groups, county urbanization levels, and in multiple states. From 2013 to 2017, synthetic opioids contributed to increases in drug overdose death rates in several states. From 2016 to 2017, synthetic opioid-involved overdose death rates increased 45.2%.
Abstracts Pt.37
Authors: Lisa Campbell, Michele Maroon, Hyun Park, South Korea, ; Sun, Young Yoon, Jun Lee, Kee Cho, Silvia Pe ´rez-Gala, Javier Pedraz, Jesu ´s Ferna ´ndez-Herrera, Amaro Garcı ´a-Dı ´ez
Journal: Journal of the American Academy of Dermatology (2006)
CHOLESCINTIGRAPHY: THE RIM SIGN IN ACUTE GANGRENOUS CHOLECYSTITIS.
Authors: Michael B. Brachman, Doina E. Tanasescu, Lalitha Ramanna, Alan D. Waxman
Journal: Clinical Nuclear Medicine (1983)

Brachman, Michael B.; Tanasescu, Doina E.; Ramanna, Lalitha; Waxman, Alan D. Author Information
Meprobamate Addiction
Authors: Robert C. Mohr, Beverley T. Mead
Journal: New England Journal of Medicine (1958)

A LITTLE over three and a half years ago, a new medication, meprobamate, was widely promoted for use in a variety of maladies. There is no doubt of its efficacy as a muscle relaxant and mild sedative. One of the most important factors that caused it to be widely accepted was its apparent freedom from toxic side effects and addiction.1 It is fortunate that meprobamate is relatively innocuous in comparison to other types of so-called "relaxing" or "tranquilizing" drugs, and as such it has been accepted by a large proportion of the lay population as a harmless panacea for a . . .
Rapid donor liver nutritional enhancement in a large animal model
Authors: R Cywes
Journal: Hepatology (1992)

Organ donors are typically subject to acute hyponutrition that might affect postpreservation liver function. Livers from nutritionally supplemented rats function better after preservation than livers from fasted rats. We have developed a method to glycogenate the liver of large animals in the temporal context of a human donor liver operation and have studied the fate of glycogen stores during preservation. Starved anesthetized pigs were infused with a hexose solution (glucose, fructose or galactose) by way of the superior mesenteric vein for 3 hr. Regular porcine insulin was infused to maintain a hyperglycemic hyperinsulinemic arterial glucose clamp at 12 to 16 mmol/L. Liver biopsy specimens and blood samples were taken before infusion and hourly. At 3 hr the liver was excised, stored for 24 hr at 1°C in University of Wisconsin solution and biopsied. It was then placed at 20° C for 1 hr to simulate the reimplantation stage of transplantation. Glycogen and nucleotide levels were measured, and results were corrected for starch in the University of Wisconsin solution. A 20% glucose infusion produced rapid hepatic glycogenation without side effects. Greater glycogenation was obtained with 20% fructose but at the cost of lactic acidosis and a fall in pH. A combination of 15% glucose and 5% fructose produced intermediary glycogenation without significant side effects. Galactose (20%) was less efficient than glucose alone. The addition of alanine and glutamine (20 mmol/L) did not significantly improve glycogenation. Metabolism of glycogen at 1° C did occur. Glycogen content fell 0.15% ± 0.05% dry weight liver per hour during cold preservation and 5.49% ± 2.15% per hour during ischemic rewarming. The rate of glycogen depletion during rewarming was dependent on the amount of glycogen available at the start of the period. Phosphorylated nucleotide levels were maintained at significantly higher levels in glycogenated livers. Periodic acid–Schiff staining showed a clear gradient of glycogenation maximal in zone 1 and minimal in zone 3. Rapid hepatic glycogenation is possible and beneficial in terms of maintaining adenine nucleotide levels in a large animal model. (HEPATOLOGY 1992;16:1271–1279.)
Organ transplant registry
Authors: J. E. Murray
Journal: JAMA (1971)

Organ transplantation, one of the most recently developed types of therapy, has been more effectively documented than most older forms of surgery. Since the early days of human renal transplantation, investigators have cooperated on a national and international scale to standardize data procurement and retrieval through the Kidney Transplant Registry. This was originated in 1963 as part of the First National Academy of Sciences—National Research Council Conference on Kidney Transplantation. Perhaps the initial motivation to collect information about human transplantation was fear of the unknown or the desire to share a misery, child-like handholding while walking through darkened woods. Nevertheless, the cooperation continued through eight consecutive reports of results and several special reports. Today, this cooperation is continuing in the expanded activities of the American College of Surgeons/National Institutes of Health Organ Transplant Registry. Now renal transplantation is a proven form of therapy with results far more acceptable than were
Affections de l'oeil en médecine générale. Diagnostic et traitement.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic Drug Targeting: Phase I Evaluation of Polymer-Bound Doxorubicin
Authors: Leonard W. Seymour, David R. Ferry, David Anderson, Stuart Hesslewood, Peter J. Julyan, Richard Poyner, Jayne Doran, Annie M. Young, Sally Burtles, David J. Kerr
Journal: Journal of Clinical Oncology (2002)

Preclinical studies have shown good anticancer activity following targeting of a polymer bearing doxorubicin with galactosamine (PK2) to the liver. The present phase I study was devised to determine the toxicity, pharmacokinetic profile, and targeting capability of PK2.Doxorubicin was linked via a lysosomally degradable tetrapeptide sequence to N-(2-hydroxypropyl)methacrylamide copolymers bearing galactosamine. Targeting, toxicity, and efficacy were evaluated in 31 patients with primary (n = 25) or metastatic (n = 6) liver cancer. Body distribution of the radiolabelled polymer conjugate was assessed using gamma-camera imaging and single-photon emission computed tomography.The polymer was administered by intravenous (i.v.) infusion over 1 hour, repeated every 3 weeks. Dose escalation proceeded from 20 to 160 mg/m(2) (doxorubicin equivalents), the maximum-tolerated dose, which was associated with severe fatigue, grade 4 neutropenia, and grade 3 mucositis. Twenty-four hours after administration, 16.9% +/- 3.9% of the administered dose of doxorubicin targeted to the liver and 3.3% +/- 5.6% of dose was delivered to tumor. Doxorubicin-polymer conjugate without galactosamine showed no targeting. Three hepatoma patients showed partial responses, with one in continuing partial remission 47 months after therapy.The recommended PK2 dose is 120 mg/m(2), administered every 3 weeks by IV infusion. Liver-specific doxorubicin delivery is achievable using galactosamine-modified polymers, and targeting is also seen in primary hepatocellular tumors.
PHOSPHORUS IN THE BODY
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastric ulcer: is endoscopy always necessary?
Authors: R H Salter
Journal: BMJ (1981)

Gastric ulcer: is endoscopy always necessary?Crucial to the management of gastric ulceration is the accurate distinction between benign and malignant lesions.Controversy continues over how this should be achieved, the conclusion from a recent retrospective study' being that all gastric ulcers should be assessed endoscopically and tissue obtained for histological diagnosis by means of multiple biopsy and brush cytology.Good-quality double-contrast radiology of the stomach appears to permit accurate prediction of whether a gastric ulcer is benign or malignant provided that the "guideline" pattern around the ulcer crater is adequately shown.2 3 If this is so endoscopy could be reserved for doubtful cases rather than being a routine procedure.Guideline patterns indicating benign ulcer (left) and malignant lesion (right).
Developing and piloting an electronic telephone triage application.
Authors: Peter G. Ellis, Christine Carlisle, Colleen F. Ford, Peggy Nikolajski, Carol Reidmiller, Leslie Stewart, Justin S. Rushford, Amanda Barry, Melinda Krebs
Journal: Journal of Clinical Oncology (2017)

e21680 Background: With the shift of cancer care to the outpatient setting, telephone triage is a vital part of today’s oncology practice. UPMC CancerCenter (UPMC) desires to streamline the current telephone triage process across its 31 outpatient clinics. UPMC and Via Oncology collaborated to develop and pilot a prototype of an electronic telephone triage application. The key components of the prototype were defined as decision support, EHR integration, reporting, and workflow management. Methods: A prototype application, Symptom Manager (SM), was developed and piloted with 4 nurses at 3 outpatient clinics. Front office staff registered inbound calls in SM, which populated a phone triage queue. The nurse was prompted to enter information about the call. Decision support materials were displayed for reference, including algorithms for symptom assessment, adjudication, and treatment. The output was a structured summary of the encounter that was copied to the patient’s chart. From the queue, the nurse was also prompted to make outbound calls for symptom reassessment. A feedback session with the nurse users and institution leadership was held following the pilot. Results: A total of 235 inbound calls were captured in the application, of which 74 (31.5%) were symptom-related. Additional data fields collected during the pilot included symptom, adjudication, time elapsed for callback, and symptom status at follow up. The ability to extract and report on data of this type was viewed as valuable for quality and process improvement. The nurse users praised SM’s ease of use, but prototype performance issues shortened the pilot. They indicated that the standardized documentation increased efficiency. Requests for future enhancements included deeper EHR integration and additional fields for data capture. Conclusions: This pilot provided the feedback necessary to develop the latest version of SM which begins roll out across UPMC in November 2016 and includes EMR integration. An update on the software and additional data captured during the pilot will be provided at presentation.
A1.26 Innate lymphoid cells are present at normal human enthesis providing a potential mechanism for spondyloarthropathy pathogenesis
Authors: RJ Cuthbert, EM Fragkakis, P Millner, R Dunsmuir, Y El-Sherbiny, D McGonagle
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background and objectives</h3> The pathogenesis of murine spondyloarthropathy (SpA) has been intimately linked to the presence of IL-23 responsive, innate like lymphocytes at peripheral and spinal enthesis. Human SpAs are associated with SNPs in genes related to the IL-23 pathway and drugs that block IL-12/23 have shown efficacy. We hypothesised that the normal human enthesis has a population of resident innate lymphoid cells (ILCs) that could be key in governing entheseal immune homeostasis partly via interaction with resident mesenchymal stromal cells (MSCs). <h3>Materials and methods</h3> Normal spinal enthesis were harvested from patients undergoing spinal decompression surgery and enzymatically digested prior to sorting or flow cytometry. Immunophenotyping and cell sorting was performed on enthesis samples harvested from 6 patients and unmatched peripheral blood. The expression of RORγt and key immunomodulatory transcripts was tested in sorted populations by RTqPCR. Anterior cruciate ligament and Achilles enthesis were obtained from patients with knee OA and Achilles tendon rupture and analysed by immunohistochemistry (IHC). Adherent cells from entheseal digest were cultured under standard MSC culture conditions and expression of known MSC markers was assessed by flow cytometry. <h3>Results</h3> All sorted samples contained ILC3s, median proportion 0.09% (range 0.015–0.63). Transcript analysis confirmed the expression of RORγt transcript in sorted ILC3 populations. ILC3s expressed 51-fold greater relative expression of RORγt in comparison to unsorted mononuclear cells. 5 of 6 sorted samples contained ILC2s, median proportion 0.20% (range 0–0.49). RORγt expression was detected in knee OA and there was widespread expression of RORγt in inflammatory infiltrates in injured enthesis as shown by IHC. Culture expanded adherent cells grew in characteristic fibroblastoid colonies and expressed phenotypic markers consistent with bone marrow derived MSCs. <h3>Conclusions</h3> Our findings show that both ILCs and MSCs are present in the normal human spinal enthesis. ILCs may also be greatly increased in frequency following injury. The co-localisation of ILC and MSC populations at the enthesis suggests a potential link between cellular dysregulation of the IL-23/17 axis and human SpA pathology.
Nosocomial pneumonia and mortality
Authors: S. A. Nishioka
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Dr Fagon and colleagues<sup>1</sup>have convincingly demonstrated that nosocomial pneumonia contributes to the death of patients in intensive care units (ICUs) independent of the confounding effect of other predictors. However, in their article they did not address whether there was any interaction between nosocomial pneumonia and the other variables that were kept in their multiple logistic regression model. It is possible that nosocomial pneumonia is completely independent of the other variables as a predictor of death in ICUs, but it is equally (or more) likely that the risk of dying from nosocomial pneumonia varies in magnitude according to the severity of the patients' baseline condition or the presence of other predictors of death. In epidemiology this phenomenon is known as "effect modification."<sup>2</sup>Taking, for example, nosocomial bacteremia, if this variable were shown to be an effect modifier, it would imply that there was a synergism
Propoxyphene
Authors: Louis J. West
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The recent demonstration of responsible action by Eli Lilly and Company in connection with dangerousness of propoxyphene hydrochloride (Darvon) is deserving of commendation. Propoxyphene has been increasingly prescribed in recent years and is now widely used. Like many effective anodynes, it is dangerous in overdoses, especially when combined with alcohol or other central nervous system (CNS) depressants. The more the drug is used the more cases of death from such overdose can be expected. Persons with psychiatric disturbances are particularly at risk. Following the report by McBay and Hudson<sup>1</sup>on increased deaths associated with the use of propoxyphene, Eli Lilly and Company sponsored a comprehensive study by the University of Utah's Center for Human Toxicology to explore the subject in depth. Even before publication of the Utah center's complete report, Ivan F. Bennett, MD, of Lilly Research Laboratories transmitted its essence to the medical profession.<sup>2</sup>