tbuckley/cabot-search huggingface dataset:
OC-016 Elevated Faecal Calprotectin Predicts Disease Progression in Crohn’S Disease
Authors: N A Kennedy, J Chang, M H Guy, T Smith, J T Loh, D Haunschmidt, M Muscat, F Fasci Spurio, H E Drummond, K Kingstone, C L Noble, A G Shand, J Satsangi, I D Arnott, C W Lees
Journal: Gut (2013)

<h3>Introduction</h3> Historical cohort studies have clearly demonstrated that over time the majority of patients with Crohn’s disease (CD) will progress from inflammatory (B1) to stricturing (B2) or fistulating (B3) disease. Emerging data suggest that more intensive treatment targeted towards mucosal healing will help to prevent disease progression. Faecal calprotectin (FC) is an established surrogate biomarker for endoscopic mucosal healing. It has yet to be established whether tailoring therapy to FC levels prevents disease progression. In the present study we aimed to determine whether FC levels in patients with established CD were predictive of disease progression. <h3>Methods</h3> The Edinburgh Faecal Calprotectin Registry (EFCR) comprises data on 22,130 FC assays in 16,278 patients from 2005–2012. Detailed phenotypic information was obtained on patients with CD by retrospective casenote review. Data collected included demographics, disease location, disease behaviour over time, CD-related surgery, investigations, hospitalisations and drug therapy. Patients were included in the main analysis if they had at least 12 months’ follow-up since first FC. The a priori primary endpoint was a composite of progression in Montreal luminal behaviour, hospitalisation for flare and resectional surgery. <h3>Results</h3> There were 881 CD patients identified with at least one FC, of which 723 had at least one year’s follow-up, with median follow-up time 40 months (IQR 25–60). The median age was 28y (IQR 20–42) at diagnosis and 40y (28–53) at time of first FC. 239 patients (33%) reached the primary endpoint, of whom 68 had had progression of their Montreal behaviour from B1 to B2 or B3, or from B2 to B3. The median of the earliest FC was significantly higher in the group that reached the primary endpoint at 586 µg/g (IQR 210–1235) vs. 289 (75–1001) in those that did not (p &lt; 0.0001). Survival analysis (Fig 1) revealed significant differences in time to progression, hospitalisation or surgery with calprotectin ≥ 200 (p &lt; 0.0001). <h3>Conclusion</h3> This large single-centre study presents compelling evidence that measurement of FC can be used to predict disease course, which creates the opportunity for physicians to intervene earlier and perhaps alter the disease course. <h3>Disclosure of Interest</h3> None Declared
LOW-FAT DIET IN MULTIPLE SCLEROSIS
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NEW INTRAVENOUS NEEDLE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Woman a Man Marries: An Analysis of Her Double Standard.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Dermatology (2020)

Skin Cancer Detection Using Convolutional Neural Network 29In this diagnostic/prognostic study, Han and colleagues evaluated a deep learning algorithm designed to identify facial lesions and predict risk of skin cancer.A total of 924 538 training image crops, including of various benign lesions, were generated with the help of a region-based convolutional neural network.Results suggest that the algorithm can localize and diagnose skin cancer without preselection of suspect lesions by dermatologists.Tschandl provides an Editorial.
Disseminated intravascular coagulation and head trauma. Two case studies
Authors: B. P. Drayer
Journal: JAMA (1975)

Disseminated intravascular coagulation (DIC) developed in two patients following head trauma. Brain parenchyma and highly vascular connective tissue of the choroid plexus and meninges are important pools of systemic coagulation components. This is an important consideration in the treatment of head injury. (<i>JAMA</i>231:174-175, 1975)
Medical discipline. Part I. Constitutional consideration--the police power
Authors: Bruce E. Vodicka
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lexikon der gesamten Therapie des praktischen Arztes mit Einschluss der therapeutischen Technik unter Mitarbiet zahlreicher Fachgenossen.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Reviews
Authors: P.E. Sifneos, U. Rosin, G.-K. Köhler, Tatjana M. Sivik, Thomas N. Wise, Lee S. Mann, Steven Epstein, Egon Stenager, Lone Knudsen, Knud Jensen, Robert H. Bull, Gabriela Legorreta, Gabriella Ba, Julian Hafner, Manuel Battegay, Rainer Weber, Jürg Willi, Dominique Eich, Walter Siegenthaler, Ruedi Lüthy, Clá;udio Laks Eizirik, Flá;via Costa, Flá;vio Kapczinski, Renato Piltcher, Rosane Gauer, Zelig Libermann
Journal: Psychotherapy and Psychosomatics (1991)
Impact of Coronary Heart Disease on World Leaders
Authors: Leslie R. Pyenson, Francis X. Brickfield, Alyce Girardi
Journal: Annals of Internal Medicine (2001)

Letters18 December 2001Impact of Coronary Heart Disease on World LeadersLeslie R. Pyenson, MD, Francis X. Brickfield, MD, and Alyce Girardi, MDLeslie R. Pyenson, MDCentral Intelligence Agency; Washington, DC 20505, Francis X. Brickfield, MDCentral Intelligence Agency; Washington, DC 20505, and Alyce Girardi, MDCentral Intelligence Agency; Washington, DC 20505Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-12-200112180-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Cheng for sharing this interesting vignette, which reinforces the importance of the relationship between health and politics. Unfortunately, we are precluded from commenting about the specifics of any individual in our study. We have privately received many positive comments on our article and want to thank the Annals staff for their editorial suggestions and for making this a painless publication experience. Author, Article, and Disclosure InformationAuthors: Leslie R. Pyenson, MD; Francis X. Brickfield, MD; Alyce Girardi, MDAffiliations: Central Intelligence Agency; Washington, DC 20505 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImpact of Coronary Heart Disease on World Leaders Alyce M. Girardi , Leslie R. Pyenson , Jon Morris , and Francis X. Brickfield Impact of Coronary Heart Disease on World Leaders Tsung O. Cheng Metrics 18 December 2001Volume 135, Issue 12Page: 1095KeywordsCoronary heart disease ePublished: 18 December 2001 Issue Published: 18 December 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Pressure Ulcers
Authors: WILLIAM M. HENDRICKS
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 August 1981Pressure UlcersWILLIAM M. HENDRICKS, M.D.WILLIAM M. HENDRICKS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-2-239_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the article on management of pressure ulcers (1), elderly patients in nursing homes should be distinguished from younger, neurologically impaired patients who develop pressure ulcers. First, the distribution of pressure ulcers is different. Over half the patients that I have examined with pressure ulcers in our local 214-bed nursing home over the past 3 years had them on their heels, sides of the feet, and malleoli. Second, most of the ulcerations in nursing home patients are readily identified and may be treated in the nursing home by an interested physician. Local débridement of the ulceration including...Reference1. REULERCOONEY JT. The pressure sore: pathophysiology and principles of management. Ann Intern Med. 1981;94:661-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Asheboro Dermatology Clinic Asheboro, NC 27203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDecubitus Ulcers 1 August 1981Volume 95, Issue 2Page: 239-239KeywordsElderlyNursing homesPressure ulcersUlcers Issue Published: 1 August 1981 PDF downloadLoading ...
Immunoproliferative Small Intestinal Disease Associated with<i>Campylobacter jejuni</i>
Authors: Marc Lecuit, Eric Abachin, Antoine Martin, Claire Poyart, Philippe Pochart, Felipe Suarez, Djaouida Bengoufa, Jean Feuillard, Anne Lavergne, Jeffrey I. Gordon, Patrick Berche, Loïc Guillevin, Olivier Lortholary
Journal: New England Journal of Medicine (2004)

Immunoproliferative small intestinal disease (also known as alpha chain disease) is a form of lymphoma that arises in small intestinal mucosa-associated lymphoid tissue (MALT) and is associated with the expression of a monotypic truncated immunoglobulin alpha heavy chain without an associated light chain. Early-stage disease responds to antibiotics, suggesting a bacterial origin. We attempted to identify a causative agent.We performed polymerase chain reaction (PCR), DNA sequencing, fluorescence in situ hybridization, and immunohistochemical studies on intestinal-biopsy specimens from a series of patients with immunoproliferative small intestinal disease.Analysis of frozen intestinal tissue obtained from an index patient with immunoproliferative small intestinal disease who had a dramatic response to antibiotics revealed the presence of Campylobacter jejuni. A follow-up retrospective analysis of archival intestinal-biopsy specimens disclosed campylobacter species in four of six additional patients with immunoproliferative small intestinal disease.These results indicate that campylobacter and immunoproliferative small intestinal disease are associated and that C. jejuni should be added to the growing list of human pathogens responsible for immunoproliferative states.
Physician-Assisted Suicide
Authors: Lois Snyder, Daniel P. Sulmasy, William E. Golden
Journal: Annals of Internal Medicine (2002)

Letters6 August 2002Physician-Assisted SuicideLois Snyder, JD, Daniel P. Sulmasy, OFM, MD, PhD, and William E. Golden, MDLois Snyder, JDEthics and Human Rights Committee American College of Physicians–American Society of Internal Medicine; Philadelphia, PA 19106Search for more papers by this author, Daniel P. Sulmasy, OFM, MD, PhDEthics and Human Rights Committee American College of Physicians–American Society of Internal Medicine; Philadelphia, PA 19106Search for more papers by this author, and William E. Golden, MDEthics and Human Rights Committee American College of Physicians–American Society of Internal Medicine; Philadelphia, PA 19106Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-3-200208060-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The College's decision to oppose the legalization of physician-assisted suicide was made after a serious, reasoned consideration of a wide variety of points of view and after a thorough examination of the medical, ethical, legal, and social ramifications of legalizing this practice.Drs. Leeman and de Torrenté raise some of the issues we considered but do not explain the basis for the right to physician-assisted suicide that they support. They also fail to acknowledge the debate about the appropriate role of medicine in caring for patients at the end of life. The College argued that medicine cannot and ... Author, Article, and Disclosure InformationAuthors: Lois Snyder, JD; Daniel P. Sulmasy, OFM, MD, PhD; William E. Golden, MDAffiliations: Ethics and Human Rights Committee American College of Physicians–American Society of Internal Medicine; Philadelphia, PA 19106 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPhysician-Assisted Suicide Lois Snyder and Daniel P. Sulmasy , for the Ethics and Human Rights Committee, American College of Physicians–American Society of Internal Medicine*Physician-Assisted Suicide Cavin P. Leeman Physician-Assisted Suicide Antoine de Torrenté Physician-Assisted Suicide Faye Girsh Metrics 6 August 2002Volume 137, Issue 3 Page: 216-217 Keywords Euthanasia Fear Health care Patients Suicide ePublished: 6 August 2002 Issue Published: 6 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Case Control Study of Syngeneic Transplantation Versus Autologous Transplantation for Multiple Myeloma: Two Decades of Experience at MD Anderson
Authors: Ghulam Rehman Mohyuddin, Muhammad Salman Faisal, Nina Shah, Qaiser Bashir, Chitra Hosing, Krina Patel, Uday R. Popat, Simrit Parmar, Gabriela Rondon, Ruby Delgado, Donna M. Weber, Jatin J. Shah, Sheeba Thomas, Elisabeth E. Manasanch, Robert Z. Orlowski, Richard E. Champlin, Muzaffar H. Qazilbash
Journal: Blood (2016)
Surgery, Gynecology and Obstetrics, Chicago
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bicuspid Aortic Valves Are Associated With Aortic Dilatation Out of Proportion to Coexistent Valvular Lesions
Authors: Martin G. Keane, Susan E. Wiegers, Ted Plappert, Alberto Pochettino, Joseph E. Bavaria, Martin G. St. John Sutton
Journal: Circulation (2000)

Background —Bicuspid aortic valves (BAVs) are associated with premature valve stenosis, regurgitation, and ascending aortic aneurysms. We compared aortic size in BAV patients with aortic size in control patients with matched valvular lesions (aortic regurgitation, aortic stenosis, or mixed lesions) to determine whether intrinsic aortic abnormalities in BAVs account for aortic dilatation beyond that caused by valvular hemodynamic derangement alone. Methods and Results —Diameters of the left ventricular outflow tract, sinus of Valsalva, sinotubular junction, and proximal aorta were measured from transthoracic echocardiograms in 118 consecutive BAV patients. Annular area was measured by planimetry, and BAV eccentricity was expressed as the ratio of the right leaflet area to the total annular area. Seventy-seven control patients with tricuspid aortic valves were matched for sex and for combined severity of regurgitation and stenosis. BAV patients (79 men and 39 women, aged 44.1±15.5 years) had varying degrees of regurgitation (84 patients [71%]) and stenosis (48 patients [41%]). Within the bicuspid group, multivariate analysis demonstrated that aortic diameters increased with worsening aortic regurgitation ( P &lt;0.001) and advancing age ( P &lt;0.05) but not with the severity of aortic stenosis. BAV patients had larger aortic diameters than did control patients at all ascending aortic levels measured ( P &lt;0.01), despite advanced age in the control patients. Conclusions —Aortic dimensions are larger in BAV patients than in control patients with comparable degrees of tricuspid aortic valve disease. Although more severe degrees of aortic regurgitation are associated with aortic dilatation in BAV patients, intrinsic pathology appears to be responsible for aortic enlargement beyond that predicted by hemodynamic factors.
Transactions of the Southern Surgical and Gynecological Association.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Omissions and Errors in Group List
Authors: Zachary Marcum
Journal: JAMA (2013)

Simon Thom, MB,BS, MD; Neil Poulter, MB, MSc, FMedSci; Jane Field, BSc; Anushka Patel, MD, PhD; Dorairaj Prabhakaran, MD, DM, MSc; Alice Stanton, MB,BS, PhD; Diederick E. Grobbee, MD, PhD; Michiel L. Bots, MD, PhD; K. Srinath Reddy, MD, DM; Raghu Cidambi, LLB; Severine Bompoint, BSc; Laurent Billot, MSc; Anthony Rodgers, MD, PhD; for the UMPIRE Collaborative Group