tbuckley/cabot-search huggingface dataset:
Granulomatous Disease in Common Variable Immunodeficiency
Authors: Charlotte Cunningham-Rundles
Journal: Annals of Internal Medicine (1998)

Letters1 May 1998Granulomatous Disease in Common Variable ImmunodeficiencyCharlotte Cunningham-Rundles, MD PhD, Laura J. Mechanic, MD, and Steven Dikman, MDCharlotte Cunningham-Rundles, MD PhDMt. Sinai School of Medicine; New York, NY 10029Search for more papers by this author, Laura J. Mechanic, MDMt. Sinai School of Medicine; New York, NY 10029Search for more papers by this author, and Steven Dikman, MDMt. Sinai School of Medicine; New York, NY 10029Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-9-199805010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Viallard and colleagues describe an unusual case of extensive granulomatous disease in a woman with common variable immunodeficiency who had a large number of peripheral double-negative CD3 (+) T cells that displayed the γδ phenotype and had a skewed variable gene segment usage. These authors suggest that the expansion of γδ T cells could be viewed as a deviation brought about in compensation for the impaired T-cell immunity. Although the search for mycobacteria was not ultimately rewarded, it remains possible that a specific microbial species was responsible for this unusual T-cell expansion. Katial and colleagues [1] described a ...References1. Katial RK, Lieberman MM, Muehlbauer SL, Lust JA, Hamilos DL. Gamma delta T lymphocytosis associated with common variable immunodeficiency. J Clin Immunol. 1997; 17:34-42. Google Scholar2. Nilssen DE, Halstensen TS, Froland SS, Fausa O, Brandtzaeg P. Distribution and phenotypes of duodenal intraepithelial γ/δ T cells in patients with various types of primary B cell deficiency. Clin Immunol Immunopathol. 1993; 68:301-10. Google Scholar3. Cunningham-Rundles C. Clinical and immunologic analyses of 103 patients with common variable immunodeficiency. J Clin Immunol. 1989; 9:22-33. Google Scholar4. Mulligan CG, Fanning GC, Chapel HM, Welsh KI. TNF and lymphotoxin-α polymorphisms associated with common variable immunodeficiency: a role in the pathogenesis of granulomatous disease. J Immunol. 1997; 159:6236-41. Google Scholar Author, Article, and Disclosure InformationAffiliations: Mt. Sinai School of Medicine; New York, NY 10029 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1998Volume 128, Issue 9Page: 782-783KeywordsAntimitochondrial antibodiesB cellsChemotherapyGenetic diseasesImmunodeficienciesIntravenous immunoglobulinLiverPhenotypesPrimary biliary cirrhosisT cells Issue Published: 1 May 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Emotions revealed
Authors: Paul Ekman
Journal: BMJ (2004)

In the second of two articles, Paul Ekman discusses how recognising your own emotions can help you communicate better In the first article I discussed two skills that can help you in your professional relationships.1 The first is becoming aware of the emotions of others by reading the brief or subtle expressions on their face. The second is knowing what to do with this information--how should you react if you see subtle signs of anger or sadness in your patient or colleague? Box 1 gives an example of how to use these skills when you are being appraised. ### Box 1: Emotional awareness during your appraisal Being criticised during an appraisal can be hard to deal with. We need to be aware of our own emotions and to try to read accurately how the person who is giving us the feedback feels. Perhaps, for example, you see subtle signs of anger on your supervisor's face during the appraisal: their lips are slightly narrowed and there is a slight tensing of their lower eyelids. It is useful to know they are angry, even though you cannot know the cause. Maybe they are angry because someone passed a message on to them about your performance that they must now pass on to you, and they are angry at being the messenger. If you see anger, the most you can say to your supervisor is: “Is there anything more I need to know about how you feel about what's happened?” In most situations, unless the person criticising you is a close colleague rather than a supervisor, you will not be able to say more than that. If you see sadness on your supervisor's face, perhaps they are disappointed in how you performed and you might say: “I'm really concerned--have I disappointed you?” or “I know I've disappointed you and I … RETURN TO TEXT
Measles immunization in a northeastern metropolitan county
Authors: R. G. Lennon
Journal: JAMA (1967)

Measles vaccination in Erie County, New York, has proceeded routinely through physicians in private practice and local health clinics. The geographic and economic patterns of measles incidence and vaccination were determined for this metropolitan area by means of a stratified random sample population survey. For children under 5 years of age, measles incidence followed an economic gradient with the upper economic strata having the lowest incidence and the lower strata having the highest. The overall measles vaccination rate was 33% for those under 10 and reached a peak of 76% among children 2 years of age. Considerably higher vaccination levels were recorded in the suburbs than in the lower economic urban and rural areas, with a decreasing gradient from the higher to the lower economic strata in each geographic area.
Problems with Institutional Review Board inconsistency
Authors: R. M. Veatch
Journal: JAMA (1982)

The study "Inconsistency and Institutional Review Boards" by Jerry Goldman, PhD, and Martin D. Katz, presented elsewhere in this issue (p 197), raises troubling and important questions for anyone concerned about the future of research involving human subjects. Presenting three research protocols purposefully modified to raise questions of methodology, consent, and other ethical issues to 22 institutional review boards (IRBs) in major academic medical research facilities, they found substantial inconsistencies in decisions to approve or disapprove the research, in reasons given for or against approval, and in the standards applied in review. Research on IRBs is extremely difficult, as it requires permission from researchers to submit protocols to this process and from IRBs willing to expend valuable time to learn something about the nature of the review process. We have previous studies of IRBs that have hinted at the problem of inconsistency,<sup>1</sup>but never before have we been able
Modulation of intercellular adhesion molecule 1 (ICAM‐1) expression on the human mast‐cell line (HMC)‐1 by inflammatory mediators
Authors: B. Wedi, J. Elsner, W. Czech, J. H. Butterfield, A. Kapp
Journal: Allergy (1996)

The effect of inflammatory mediators on the expression of several surface adhesion molecules on the human mast‐cell line (HMC)‐1 was studied. By flow cytometry, it could be shown that among several surface adhesion molecules (ICAM‐UCDS4, VLA‐4/CD49d, Mac‐UCD11b, LFA‐1/CD11a, LFA‐2/CD2, LFA‐3/CDS8, VCAM‐1), only the constitutively expressed immunoglobulin family member intercellular adhesion molecule‐1 (ICAM‐1) is modulated by proinflammatory cytokines on HMC‐1 mast cells. Stimulation with tumor necrosis factor‐a (TNF‐α) and interferon‐γ (IFN‐γ) resulted, in addition to interleukin‐(lL‐)4, in selective upregulation of ICAM‐1 expression. Costimulation of either IL‐4 or IFN‐γ with TNF‐α further increased the ICAM‐1 expression as compared to the stimuli alone. In contrast, stem‐cell factor (SCF), granulocyte/macrophage colonystimulating factor (GM‐CSF), IL‐10, IL‐8, monocyte chemotactic and activating factor (MCAF), and the complement split product C5a failed to modulate the expression of any adhesion molecule examined. The levels of cytoplasmic free calcium in HMC‐1 mast cells were not altered by cross‐linking surface ICAM‐1, suggesting linkage of other intracellular signaling pathways. This cytokine‐induced upregulation of ICAM‐1 expression might reveal a putative regulatory mechanism of mast‐cell interaction with effector cells bearing the counterparts of ICAM‐1 (CD54), the molecules Mac‐1 (CD11b/CD18) and leukosialin (CD43), and the principal ligand LFA‐1 (CD11a/CD18).
Psychotherapy
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Life and Evolution. An Introduction to General Biology.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of HIV Case Surveillance Through the Use of Non-Name Unique Identifiers—Maryland and Texas, 1994-1996
Journal: JAMA (1998)

Notifiable disease reporting laws or regulations in states and territories require reporting of acquired immunodeficiency syndrome (AIDS) cases, including patient and physician names, to state or local health authorities. As of January 1, 1998, a total of 31 states were conducting name-based human immunodeficiency virus (HIV) case surveillance by using the same methods as surveillance for AIDS. However, because of concerns about name-based HIV surveillance, Maryland and Texas implemented HIV surveillance using non-name unique identifiers (UI). This report summarizes a 3-year collaboration by CDC and these states to evaluate UI surveillance for HIV infection; the findings indicate some limitations to the use of a Social Security number-based UI for HIV surveillance.
Errors in Caption to Figure 2
Journal: JAMA Internal Medicine (2019)

Nicolas Wentzensen, MD, PhD, MS; Megan A. Clarke, PhD; Renee Bremer, MS; Nancy Poitras, BS; Diane Tokugawa, MD; Patricia E. Goldhoff, MD; Philip E. Castle, PhD; Mark Schiffman, MD; Julie D. Kingery, MD; Kiranjit K. Grewal, MS; Alex Locke, MD; Walter Kinney, MD; Thomas S. Lorey, MD
Child Drownings and Near Drownings Associated With Swimming Pools—Maricopa County, Arizona, 1988 and 1989
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: C. FRETER
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Handbook of Medical Oncology. Gianni Bonadonna, Gioacchino Robustelli della Cuna, eds. Chicago: Year Book Medical Publishers, Inc., 1988, 1,125 pp. $120. CARL FRETER CARL FRETER Vincent T. Lombardi Cancer, Research Center, Georgetown University Medical Center3800 Reservoir Rd., N.W. Washington, DC 20007 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 21, 1 November 1989, Page 1665, https://doi.org/10.1093/jnci/81.21.1665 Published: 01 November 1989
ON NOT EATING YOUR NEIGHBOR
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Report on Cancer of the Rectum. An Analysis of the Literature with Special Reference to the Results of Operation. Reports on Public Health and Medical Subjects No. 46: Ministry of Health, London.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Nervous Breakdown
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute reactant cytokines and neutrophil adhesion after warm ischemia in cirrhotic and noncirrhotic human livers
Authors: P Clavien
Journal: Hepatology (1996)

Animal studies suggest that acute phase reactant cytokines and polymorphonuclear leukocytes (PMN) may play a critical role in ischemia- reperfusion injury. To evaluate whether similar mechanisms are operative in human liver, six cirrhotic and nine noncirrhotic patients undergoing right hepatectomy were randomized for utilization of hepatic vascular exclusion (HVE) as a model of ischemia-reperfusion injury. Portal and systemic levels of acute reactant cytokines (interleukin 6 [IL-6], interleukin 1 [IL-1], tumor necrosis factor α [TNF-α]) and neutrophil adhesion in serial liver biopsy specimens were studied. Correlations among mediators, leukocyte adhesion, and markers of liver injury were also evaluated. Hepatic vascular exclusion resulted in substantial and reproducible changes in portal and arterial IL-6 levels in both cirrhotic and noncirrhotic patients. Portal and systemic cytokine levels were comparable in most instances, whereas levels were usually higher in cirrhotic patients than in noncirrhotic patients. Negative correlations were found between IL-6 levels at the time of reperfusion and later TNF-α levels. IL-6 levels correlated negatively with numerous markers of hepatocellular injury and the number of postoperative complications. Hepatic vascular exclusion increased neutrophils adhesion after reperfusion in cirrhotic patients but not in noncirrhotic patients. In cirrhotic patients, the degree of leukocyte adhesion after reperfusion correlated with several postoperative markers of liver injury. This study in humans shows that acute reactant cytokines are released during liver ischemia and, interestingly, that IL-6 levels strongly correlate with clinical and laboratory measures of injury. Further studies to evaluate possible causal relationship with hepatic injury are warranted, with emphasis on the role of IL-6 and PMN adhesion.
Subphrenic abscess. Myths and facts
Authors: N. A. Halasz
Journal: JAMA (1970)

Missed synchronous abscesses were found to contribute greatly to therapeutic failure in the management of subphrenic abscesses. In a study of 43 patients, such failures were almost entirely limited to those patients whose abscesses were drained by various extraperitoneal approaches. Transperitoneal operation, in contrast, made adequate exploration of the several potential abscess sites possible, and permitted complete drainage of all synchronous purulent collections, with corresponding reduction in second operations and death rates. The classic recommendation for extraserous drainage is not supportable on the basis of this study.
Instruction Courses
Authors: Melvin Rubin, Ronald Fishman, John Glotfelty, Malcolm Luxenberg, Robert Stamper, Jonathan Trobe, Richard Van Reuven, George Waring, Robert Whinery, Vin Mel, Cantrill Carr, Choromokos Ophthalmic Photography, Conway Crawford, Drance Enright, Faye Federman, Fonda France, Grayson Hartstein, Hessburg Hetherington, Tripathi Wilensky, Acers Allen, Worthen Yee, Buxton Coles, Daily Della, Rocca Emery, Fetkenhour Hartstein, Havener Kimbrough, Perry Reiland, Sanders Sarrail, Girard Trans, Pars Plana, Microendosurgery Th, Winslow Wi, Worthen Boyd, Herbert Cantrill, Jonathan Pederson, William Knobloch, Robert Ramsay, Ronald Carr, New York, Irwin Siegel, Steven Charles, C O'malley, San Jose, Albert Frederick, Charles Wilkinson, Earl Choromokos, Ken Christopherson, Royal Oak, Gerald Hoover, Jerry Sewell, Mort Enright, Eleanor Faye, Jay Federman, William Annesley, William Tasman, Lov Sarin, William Benson, Alfred Lucier, ; Madison Slusher, Gerald Fonda, N Low, Thomas France, John Baker, William Scott, Gary Rogers, Merrill Grayson, Fred Wilson, Jeffrey Day Lanier, Jack Hartstein, St Louis, Joseph Baldone, New Orleans, James Gordon, Melvin Freeman, James Aquavella
Journal: Ophthalmology (1981)