tbuckley/cabot-search huggingface dataset:
From the NIH: New standards for classification and diagnosis of diabetes
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary excess and deficiency or renin.
Journal: BMJ (1973)

Primary Excess and Deficiency of ReninDiseases of endocrine glands characteristically are associated with syndromes botih of overproduction and deficiency of the relevant hormone.Study of such cases is important for an understanding of the normal working of the gland and the nature or even existence of its hormone.Renin was amongst the first of the hormones to be described: R. Tigerstedt and P. G. Bergman' suggested in 1898 that renin might be released from the kidney into blood and thus influence peripheral blood vessels.This preceded by several years E. H. Starling's2 3 definition of the hormone as a blood-borne chemical messenger.Even so, 60 years then elapsed before renin appeared in endocrinology texts.The neglect may have been due in part to the lack of syndromes associated with primary hyperand hyporeninism.Both have been described recently.During the last six years at least six cases with supposed renin-secreting haemangiopericytoma of the kidney have been reported.4-9The first was a full description4 of a young man whose hypertension was relieved by surgery which included the removal of a kidney with a renin-containing vascular tumour.This case is perhaps the least certain be- cause renin was not measured in blood before operation, and the fall of blood pressure may have been partly due to removal of adrenal tissue.Nevertheless, the remaining five patients are remarkably similar: their age varied from 13 to 37, and most presented with severe hypertension and hypokalaemia, leading at first to a suspicion of primary hyperaldosteronism (Conn's syndrome).At least two were subjected to laparotomy with this diagnosis in mind.However, high circulating levels of renin, renin activity, or angiotensin II preoperatively5-9 were strongly against the d'agnosis.Instead they pointed more to one of the secondary forms of hyperaldosteronism in which overactivity of the renin-angiotensin system occurs with increaEed aldosterone.This was borne out by the raised aldosterone levels in three out of four patients.The exception9 had been subjected previously to subtotal adrenalectomy.At this stage of the investigations most physicians would justifiably suspect either malignant-phase hypertension10 or renal vascular disease1' as the cause of secondary hyperaldosteronism.But not all patients had evidence of the malignant phaEe, and in none of the five subjected to arteriography was there evidence of renal vascular disease, C) BRITISH
A large scale expression study associates uc.283-plus lncRNA with pluripotent stem cells and human glioma
Authors: Marco Galasso, Paola Dama, Maurizio Previati, Sukhinder Sandhu, Jeff Palatini, Vincenzo Coppola, Sarah Warner, Maria E Sana, Riccardo Zanella, Ramzey Abujarour, Caroline Desponts, Michael A Teitell, Ramiro Garzon, George Calin, Carlo M Croce, Stefano Volinia
Journal: Genome Medicine (2014)

There are 481 ultra-conserved regions (UCRs) longer than 200 bases in the genomes of human, mouse and rat. These DNA sequences are absolutely conserved and show 100% identity with no insertions or deletions. About half of these UCRs are reported as transcribed and many correspond to long non-coding RNAs (lncRNAs). We used custom microarrays with 962 probes representing sense and antisense sequences for the 481 UCRs to examine their expression across 374 normal samples from 46 different tissues and 510 samples representing 10 different types of cancer. The expression in embryonic stem cells of selected UCRs was validated by real time PCR. We identified tissue selective UCRs and studied UCRs in embryonic and induced pluripotent stem cells. Among the normal tissues, the uc.283 lncRNA was highly specific for pluripotent stem cells. Intriguingly, the uc.283-plus lncRNA was highly expressed in some solid cancers, particularly in one of the most untreatable types, glioma. Our results suggest that uc.283-plus lncRNA might have a role in pluripotency of stem cells and in the biology of glioma.
Abstract 3727: Meeting Quality of Care Goals for Hypercholesterolemia: Understanding Deficiencies for Women and Black Men Compared With Non-Black Men
Authors: Barbara J Turner, Christopher S Hollenbeak, Mark G Weiner, Craig S Roberts
Journal: Circulation (2007)

BACKGROUND: CAD risk reduction requires maintaining LDL cholesterol (LDL) below NCEP goals. We examined time to LDL control for women and black men versus non-black men and examined the role of demographic, clinical, or health care factors in observed differences. METHODS: Among 35,165 patients at 6 academic primary care practices from 1/1/03 to 2/8/05, we used electronic medical records to identify 11,536 patients at increased risk of CAD due to hypertension (HTN) and age (&gt;45 if male and &gt;55 if female) and an LDL from 1/1/00 to 2/28/05. For 6,497 patients (56%), the last LDL was high (i.e., ≥130 mg/dl or high risk ≥100 mg/dl) before or at the start of our timeframe. We studied 5,146 patients with 2+ visits after that LDL and complete data. Hazard ratios (HR) for the outcome - LDL control - came from survival (Cox) models with censoring 6 months after the last visit or the study end if no LDL control. Models adjust for demographics (age, income, insurance), clinical factors (discordant comorbidities such as asthma, concordant comorbidities such as CAD, smoking, obesity, LDL level), health care (N of HTN drugs, visits/month, provider gender, race, type, annual patient workload), and time from high LDL to next visit in study timeframe. RESULTS: 47% of the cohort had LDL control within two years. Median days (d) to LDL control were: 456 d for non-black men (N=1,058); 627 d for non-black women (N=1,563); 698 d for black men (N=1,114); and 828 d for black women (N=2,164) (p&lt;0.001). Compared to non-black men, adjusted HRs of LDL control were still lower for: non-black women (0.73, CI 0.64–0.82), black men (0.73, 0.63–0.85), and black women (0.59, CI 0.51–0.67). LDL control was positively associated with discordant comorbidities, anti-HTN drugs, age 61–80 vs &lt;50, and shorter time from high LDL to next visit. Low income, Medicaid/uninsured vs commercial insured, and very high baseline LDL were negatively associated. CONCLUSIONS: Among HTN patients at increased risk of CAD, time to LDL control was significantly longer for all women and black men than non-black men and not due to many patient and health care factors. Access to and acceptance/persistence with lipid-lowering medication likely contribute to these important disparities in CAD risk reduction.
Hyperthyroidism
Authors: Gordon N. Gill
Journal: Annals of Internal Medicine (1995)

Letters1 March 1995HyperthyroidismGordon N. GillGordon N. GillSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-5-199503010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their review, Klein and colleagues [1] state that radioiodine is the “preferred” treatment for Graves disease. Although this is the most frequently chosen form of therapy in the United States, antithyroid drug therapy is most often used in Europe and Japan [2]. Historical, social, and cultural factors underlie, in part, these geographic differences in choices of therapy. Arguments can be made for each form of therapy, but, given the differing practices around the world, radioactive iodine is “preferred” only because it is currently the therapy most widely used by U.S. physicians and not necessarily because it ...References1. Klein I, Becker DV, Levey GS. Treatment of hyperthyroid disease. Ann Intern Med. 1994; 121:281-8. Google Scholar2. Wartofsky L, Glinoer D, Solomon B, Nagataki S, Lagasse R, Nagayama Y, et al. Differences and similarities in the diagnosis and treatment of Graves' disease in Europe, Japan, and the United States. Thyroid. 1991; 1:129-35. Google Scholar3. Hashizume K, Ichikawa K, Sakurai A, Suzuki S, Takeda T, et al. Administration of thyroxine in treated Graves' disease. N Engl J Med. 1991; 324:947-53. Google Scholar4. Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA. 1984; 251:365-74. Google Scholar5. DCCT Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1994; 329:977-86. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1995Volume 122, Issue 5Page: 393-394KeywordsDrug therapyHyperthyroidismThyroxine ePublished: 15 August 2000 Issue Published: 1 March 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Telephone consultations
Authors: Louise S van Galen, Josip Car
Journal: BMJ (2018)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Telephone consultations Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
A Phase IIa, Open-Label, Randomized, Pharmacokinetic Comparative, Cross-Over Studyof Melphalan HCl for Injection (propylene glycol-free) and Alkeran for Injection for Myeloablative Conditioning In Multiple Myeloma Patients Undergoing Autologous Transplantation.
Authors: Omar Aljitawi, Siddhartha Ganguly, Sunil Abhyankar, J. Daniel Robinson, J, D. Pipkin, Joseph McGuirk
Journal: Blood (2010)
A critique of low-carbohydrate ketogenic weight reduction regimens. A review of Dr. Atkins' diet revolution
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Simultaneous serum and CSF antibodies in herpes simplex virus encephalitis
Authors: D. P. Levine
Journal: JAMA (1978)

Serial concomitant paired sera (S) and CSF were taken from eight patients with biopsy-proved herpes simplex virus encephalitis (HSVE). These specimen pairs were compared with 28 others from patients with various neurologic conditions. Before and after reduction with 2-mercaptoethanol, a ratio of S/CSF antibody titers of ≤20 with either the passive hemagglutinating (PHA) or immune adherence hemagglutinating (IAHA) antibody tests occurred in every patient with HSVE. Diagnostic S/CSF ratios were noted in three patients before biopsy of the brain and in four patients by the tenth day of neurologic disease. Among control subjects, a ratio of S/CSF titers &gt;20 was observed in all but four patients. Each of the latter patients had neurologic diagnoses easily distinguishable from HSVE. The PHA or IAHA S/CSF ratio offers a rapid, reliable method for the diagnosis of HSVE (<i>P</i>&lt;.001). (<i>JAMA</i>240:356-360, 1978)
CLINICAL LECTURE on a CASE of LOCALISED MYELITIS, Affecting the Fifth Lumbar and the Secral Segments of the Spinal Cord, the Result of a Slight Traumatic Injury and a CASE of PARALYSIS of ALL FOUR LIMBS. DUE to a SPINAL INJURY: Delivered at the Edinburgh Royal Infirmary
Authors: B. Bramwell
Journal: BMJ (1898)
Clinical phonocardiography. II. Its use in the evaluation of aortic stenosis
Authors: M. E. Tavel
Journal: JAMA (1967)

The clinician is often confronted with an intense systolic murmur, heard maximally at the base, but also well at the apex. Among the several causes for such a murmur, aortic stenosis is usually an important consideration. Simple tests to assess the presence and severity of aortic stenosis are particularly important, since for definitive evaluation, the relatively difficult and hazardous technique of catheterization of the left side of the heart is required. The phonocardiogram, together with the indirect carotid-pulse tracing, provides a safe means to obtain valuable information about the condition of the aortic valve and surrounding structures. Stenosis in the aortic region may be confined to the valve or involve the tissues immediately above or below this structure. Moreover, the narrowing may be "fixed," meaning that its caliber remains constant throughout the cardiac cycle, or it may be variable, as in the case of idiopathic hypertrophic subaortic stenosis (muscular subvalvar
Orthopedics
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Treatment of Acute Dehydration in Infants.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MURDERING MOTHERS
Authors: WERNER TUTEUR, JACOB GLOTZER
Journal: American Journal of Psychiatry (1959)

Five cases of filicide committed by mothers are reported. Filicide remains an abnormality, primarily restricted to the female. Faulty relationships to either parent or extremely poor marital adjustment, or both, were present in each case. Four cases were combined with serious suicidal attempts, and a feeling of general inadequacy and inability to raise children was admitted by all mothers. All 5 appeared regretful of the act and state that they would never repeat it. The disparity between logic and affectivity was so strong in each case during commitment of the act that a diagnosis of schizophrenic break was justified in all 5. Motivations of punishment, revenge and secondary gain, as usually seen in ordinary murders were, to all appearances, completely absent. The primarily conceived suicidal attempts of the mothers rule these out almost logically. Thus, the suicidal attempts in no way represent an escape from the legal consequence of having done away with human life. A general feeling of unacceptance led to the suicide, and the "total-all"–including anything that belonged to the mother–had to abandon earthly existence, hence the combined filicide-suicide. Two cases involved 2 and 3 victims, respectively, the remainder one each. The mode of killing differed: two cases of shooting, one each of choking, poisoning and drowning. Ages of mothers ranged from 27 years to 47 years, of victims from 3 to 14 years.
Diagnostic features of malfunction of disk mitral valve prostheses
Authors: J. K. Stross
Journal: JAMA (1971)

The x-ray film of the chest, by giving clear evidence of incomplete closure of the disk valve, was diagnostic of prosthetic valve malfunction in two patients. Potentially lethal malfunction of a prosthetic disk valve can be treated successfully by operation if the diagnosis is made early in the clinical course. The medical history is helpful. The physical examination can lead to the diagnosis, but the results may be normal in the presence of valve malfunction. It may be possible to detect malfunction in the majority of instances by x-ray film of the chest and fluoroscopy, but if these studies are inconclusive when malfunction is suspected, cardiac catheterization and cineangiography should be done promptly.
Pregnancy in kidney transplant recipients seems successful, but . .
Authors: J. Henahan
Journal: JAMA (1983)

Well managed, the great majority of pregnancies in kidney transplant recipients have apparently successful outcomes, although gestation and delivery are not necessarily complication-free, according to the results of a large international survey reported at the Second European Meeting on Renal Diseases in Milan. (These findings are fairly consistent with those of a much smaller Canadian study [<i>Am J Obstet Gynecol</i>1983;145:193].) An analysis of 1,068 pregnancies that occurred in 717 transplant recipients seen at 64 centers worldwide shows that after the first trimester, the success rate is 90%, stated John M. Davison, MB, of the Medical Research Council's Human Reproduction Group at Newcastle-upon-Tyne, England. He warned, however, that long-term effects of immunosuppressant drugs on the fetus are not known. The first-trimester spontaneous abortion rate, 13%, was no higher than in the normal population. However, the incidence of therapeutic abortions in the same period was about 28%, Davison noted, commenting: "These
Molecular Classification of Multiple Myeloma: A Distinct Transcriptional Profile Characterizes Patients Expressing CCND1 and Negative for 14q32 Translocations.
Authors: Luca Agnelli, Silvio Bicciato, Michela Mattioli, Sonia Fabris, Daniela Intini, Donata Verdelli, Luca Baldini, Fortunato Morabito, Vincenzo Callea, Alberto Zanella, Giorgio Lambertenghi Deliliers, Luigia Lombardi, Antonino Neri
Journal: Blood (2005)
Depression and anxiety among family caregivers of patients with advanced cancer.
Authors: Joel Nathan Fishbein, Ryan David Nipp, Areej El-Jawahri, William F. Pirl, Samantha Moran, Caitlin McCarty, Justin Eusebio, Emily R. Gallagher, Elyse R. Park, Vicki A. Jackson, Joseph A. Greer, Jennifer S. Temel
Journal: Journal of Clinical Oncology (2015)

9514 Background: Despite the important role family caregivers (CGs) play in the care of patients with cancer, little is known about their psychological distress. We sought to describe rates and correlates of depression and anxiety in CGs of patients with advanced cancer to determine those at greatest risk for psychological distress. Methods: As part of an ongoing trial of early palliative care, we are assessing baseline depression and anxiety in patients within 8 weeks of advanced lung or gastrointestinal cancer diagnosis and their CGs. We are administering the Hospital Anxiety and Depression Scale (HADS), subscale scores >7 denoting clinically significant depression or anxiety. We are assessing patient coping styles with the Brief COPE. We used multiple logistic regression with purposeful selection of covariates to identify correlates of CG depression and anxiety. Results: Of 240 CGs (mean age=57 years), 156 (65%) were spouses/partners, 167 (70%) were female, and 131 (55%) were working. 37 (15%) and 102 (43%) CGs reported significant depression and anxiety, respectively. CG age, gender and employment status, as well as patients’ anxiety and lack of acceptance coping, were associated with higher rates of CG depression. CG age, gender, marital status and education level, as well as patients’ anxiety and presence of brain metastases were associated with higher rates of CG anxiety. Conclusions: Younger, female CGs were at greatest risk of both depression and anxiety. Thus, this CG population should be monitored closely and referred for cancer center support services for distress management. We also found that patients’ anxiety was associated with higher rates of both CG depression and anxiety, underscoring the importance of interventions that address both patient and CG psychological distress. CG Depression CG Anxiety Covariates OR P Covariates OR P CG CG Age 0.94 0.02 Age 0.97 0.02 Female 4.60 0.03 Female 2.36 0.01 Working 0.21 0.01 Married to patient 5.74 <0.01 Patient College education 0.53 0.04 Income > 50k 2.02 0.21 Lives with patient 1.60 0.40 Children 3.00 0.07 Patient Cancer type 0.47 0.14 Cancer type 1.60 0.17 Reports goal of care is cure 2.14 0.14 Brain metastases 2.30 0.05 Anxiety 3.32 0.02 Anxiety 2.81 <0.01 Acceptance coping 0.66 <0.01