tbuckley/cabot-search huggingface dataset:
The intraportal lymphoid nodule and its environment in chronic active hepatitis C: An immunohistochemical study
Authors: J Mosnier
Journal: Hepatology (1993)

Intraportal lymphoid nodules have been observed in liver biopsy specimens from patients with autoimmune liver disease and chronic active hepatitis C. They are characterized by a nodular lymphocyte aggregate with a germinal center. The purpose of this in situ immunophenotyping study was to determine immunohistochemically the phenotype of immunocompetent cells in and around intraportal lymphoid nodules in patients with chronic hepatitis C. For comparison, we also examined lymphoid nodules in patients with autoimmune liver disease. Liver biopsy specimens from 13 unselected patients with CAH and hepatitis C antibodies and from 7 unselected patients with autoimmune liver disease seen during the same period were studied. Sections of snap-frozen specimens were immunostained with monoclonal antibodies directed against different subsets of T cells, B cells, follicular dendritic cells and macrophages. Intraportal lymphoid nodules were observed in 11 of 13 patients with chronic hepatitis C. They appeared as lymphoid follicles with activated B cells in germinal centers surrounded by a follicular dendritic cell network. A mantle zone of B cells was present around the aggregate of activated B cells. A T-cell zone comprising CD4-positive helper T cells, CD8-positive suppressor/cytotoxic T cells and a few CD25-positive activated T cells expressing interleukin-2 receptor was seen at the periphery of the nodules. Human leukocyte antigen DR was expressed by B cells and by T cells, indicating that T cells were activated. The immunocompetent cells observed in piecemeal necrosis were predominantly CD4 helper T cells, whereas those seen in the lobule were predominantly CD8 suppressor/cytotoxic T cells. Some polytypic plasma cells were present in piecemeal necrosis. Intraportal lymphoid nodules were also observed in one patient with type 1 autoimmune chronic hepatitis and in one patient with primary sclerosing cholangitis. These nodules had a pattern indistinguishable from that observed in the patients with chronic hepatitis C. Similarly, immunocompetent cells of piecemeal necrosis and liver lobule shared a similar phenotype. We conclude that intraportal lymphoid nodules seen in chronic hepatitis C may be true functional lymphoid follicles, which induce stimulation of effector T cells and B cells. The characteristics of the nodules, their similarity with those observed in autoimmune liver disease and the presence of autoantibodies suggest an immune mechanism in the liver injury of chronic hepatitis C virus infection. (HEPATOLOGY 1993;17:366–371.)
Masthead
Authors: Paul Berk, New York, Andres Blei, Henry Bodenheimer, Herbert Bonkovsky, M Worcester, Michael Gerber, Robert Glickman, A Hoofnagle, Ann Hubbard, Albert Jones, N Francisco, Esteban Mezey, Kunio Okuda, Allan Wolkoff, Lawrence Friedman, M Boston, T Liang, Irwin Arias, Steven Schenker, Michelle Britton, Debra Segura, Data Meyer, D Montgomery Bissell, Anthony S A N Francisco, Eugene Schiff, John Gollan, Joseph Councillors, Neil Bloomer, Los Kaplowitz, C Angeles, Nicholas Larusso, M Rochester, Marion Councillor-At-Large, St Peters, Jay Hoofnagle, Michael Baltimore, William Lee, Jules Dienstag, Joseph Bloomer, M Minneapolis, Andrew Klein, Glen Arm, Anna Lok, New Orleans, Kevin Mullen, Robert Cleveland, Adrian S U N Francisco, Steven Reuben, Sun Schenker
Journal: Hepatology (1995)
Medical Organization
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Advances in islet cell transplantation: is science closer to a diabetes cure?
Authors: A. Skolnick
Journal: JAMA (1990)

RECENT ADVANCES in islet cell transplantation research may provide some encouragement for the long-held hope that a cure for insulin-dependent diabetes mellitus someday may be possible. As has been pointed out by Gordon C. Weir, MD, and colleagues (<i>Diabetes</i>. 1990;39:401-405), "the lack of any successful human islet transplants has been very frustrating for participants and observers." Probably the most promising advance in this regard has been the recent achievement of at least temporary insulin independence in two patients in pilot studies at Washington University School of Medicine in St Louis, Mo. At the 50th Annual Meeting and Scientific Sessions of the American Diabetes Association, in Atlanta, Ga, David W. Scharp, MD, associate professor of surgery at Washington University, reported that the latest patient with diabetes to undergo islet transplantation at his center continued to be insulin independent several weeks after receiving the transplant. That patient is still free from having
Malposition of a Subclavian Line
Authors: David D. Oakes
Journal: JAMA (1975)

THE USE of hyperosmolar intravenous solutions to provide positive nitrogen and calorie balance in patients unable to maintain adequate nutrition by conventional means has become a well-established clinical technique. Because of their hypertonicity, such solutions must be administered into an area of rapid blood flow with adequate mixing. This usually involves the placement of a central venous catheter. The metabolic and septic complications of total parenteral nutrition have been reviewed extensively. Complications of catheter placement have also been reported, including pneumothorax, pleural effusion, thrombophlebitis, brachial plexus injury, mediastinal hematoma, and carotid artery laceration. We recently encountered a complication that has not been reported in the literature, to our knowledge. This complication was manifested by pleural effusions, interstitial pulmonary edema, and chest wall abscess. It occurred because of catheter malposition undetected by the usual methods of confirming line placement. <h3>Report of a Case</h3> A 35-year-old woman was transferred to the Peter
Hysteroid dysphoria: an unsuccessful attempt to demonstrate its syndromal validity
Authors: R L Spitzer, J B Williams
Journal: American Journal of Psychiatry (1982)

Hysteroid dysphoria has been described as a chronic illness characterized by recurrent periods of depression precipitated by a specific type of stress and associated with a histrionic personality. In addition, there are specific atypical symptoms. The authors tested the syndromal validity of this proposed category in a sample of 1,324 patients with mild depression reported on by psychiatrists in a questionnaire survey. They found 41 (3.1%) who fit a pattern consisting of the basic features of the condition. However, patients who fit this pattern were not more likely to have substantially more atypical symptoms than patients without this pattern. The authors conclude that the syndromal validity of hysteroid dysphoria is not supported.
Chronic Infection of the Lingula With Bronchial Lymphadenopathy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial peer review in US medical journals
Authors: A. C. Weller
Journal: JAMA (1990)

This study determined if the process of editorial peer review is the same for all medical journals. Two categories of indexed US medical journals were examined: group 1 consisted mainly of well-known, clinically oriented journals, while group 2 was composed primarily of interdisciplinary or specialized journals. Data were collected through a series of interviews and questionnaires. All 16 group 1 editors or managing editors were interviewed. Questionnaires were mailed to 124 group 2 editors (69.4% were returned). Results showed that, although some of the practices of editorial peer review are the same, the two groups of journals had distinct editorial peer review practices. Group 1 made less use of editorial peer review than group 2 by relying on the editorial staff at several important decision points. (<i>JAMA</i>. 1990;263:1344-1347)
Abstract 1750: USP22 directly interacts with PALB2 and is required for efficient homologous recombination of DNA double-strand breaks
Authors: Isaac K. Nardi, Jeremy Stark, Adrien Larsen, Dan Raz
Journal: Cancer Research (2019)

Abstract DNA damage by environmental stressors and agents is a huge problem for cells and must be repaired quickly for the cell to maintain its integrity. Cells employ several repair pathways and mechanisms to rectify damaged DNA. Homologous Recombination (HR) repair comprises a series of pathways in a cell that can function to repair DNA double-stranded breaks (DSBs) through template-dependent mechanisms to preserve genomic integrity. Failure to repair DSBs can result in chromosomal loss, carcinogenesis, and apoptosis. Deubiquitylases (DUBs) are a family of proteases that cleave ubiquitin from proteins and have been implicated in several biological processes including tumor development, cell growth, cell cycle regulation, and signal transduction. There is a growing catalog of studies showing the vital role of DUB’s in the DNA Damage Response (DDR). But, given that there are over 100 DUBs in the human genome their functions in DDR have still not been fully fleshed out. Along with its role in antibody class switch repair, USP22 is a DUB that has been implicated as a putative oncogene with over-expression observed in various cancer types and is associated with a poor patient prognosis. Furthermore, over-expression of USP22 leads to cisplatin resistance in lung cancer cells strongly suggesting it plays in a vital role in DDR and chemoresistance in recurrent cancers. In this study we show USP22 is necessary for HR, localizes to sites of DNA damage, and is necessary for recruitment of the PALB2-BRCA2-Rad51 complex through stabilizing PALB2 protein levels. Lastly, we show USP22 directly binds to the WD40 domain of PALB2 and this binding stimulates USP22 catalytic activity. Taken together, these findings show a new and novel role of USP22 in the HR pathway. Note: This abstract was not presented at the meeting. Citation Format: Isaac K. Nardi, Jeremy Stark, Adrien Larsen, Dan Raz. USP22 directly interacts with PALB2 and is required for efficient homologous recombination of DNA double-strand breaks [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1750.
Lack of effect of direct-current cardioversion on fibrinolysis
Authors: U. M. Derman
Journal: JAMA (1966)

As direct-current conversion of cardiac arrhythmias is attaining ever increasing popularity, it is important to establish the effect of this procedure on the blood coagulation. The effect of electro-shock therapy on fibrinolysis<sup>1,2</sup>has been studied, but we are not aware of any previous coagulation studies on patients who have undergone closed "cardioversion." In order to evaluate this problem, euglobulin clot lysis<sup>3</sup>determinations were done before and after direct-current cardioversion in 12 patients. <h3>Materials and Methods.—</h3> Twelve patients, who received direct-current shocks for the conversion of cardiac arrhythmias were included in this study. In all cases the same apparatus was used to deliver the electrical shock. The capacitor discharge was synchronized with the electrical activity of the heart and programmed to be delivered on the downstroke of the R wave. One electrode was placed over the sternum, and the other in the left midaxillary line. Routinely, 100 watt-seconds of
Lack of Effect on Hypothalamic-Pituitary-Adrenal (HPA) Axis Function by Once-daily Fluticasone Furoate∗ Nasal Spray (FFNS) 110 mcg in Adolescents and Adults with Perennial Allergic Rhinitis (PAR) ∗USAN approved name
Authors: D. Patel, P. Ratner, D. Clements, W. Wu, M. Faris, E. Philpot
Journal: Journal of Allergy and Clinical Immunology (2007)
What About Sterilization
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Volume 5 contents
Authors: Stephen Ester, Cheuk Yung, Mary Massa, John Doyle, John Arlette, Margaret Johnston, Roberta Palestine, Steven Kossard, Charles Dicken, Keyoumars Soltani, Allan Lorincz, Miriam Brysk, Eduardo Tschen, R Hudson, Edgar Smith, W Fleischmann, Homer Black, Ralph Coskey, Eugene Monroe, Alexander Breslow, Charles Balch, C Mccuistion, Lois Matsuoka, Brian Potter, Melvyn Chase, A Reply, Franz Bauer, C Ralph, Daniel Iii, Emily Omura, Lamar Osment, A Perfume, Marvin Rapaport, Los Angeles, Jere Guin, Donald Pillsbury, Herman Beerman, Bruce Thiers, Howard Maibach, San Francisco, Patricia Engasser, Danny Scott, Robert Lewis, Walter Shelley, Prapand Apisarnthanarax, Actinic Prurigo, S Randy, Scheen Iii, Suzanne Connolly, Robert Johnson, Lowell Goldsmith, Jeffrey Greenwald, John Parrish, Kurt Jaenicke, R Anderson, Ben Raimer, Sharon Rairuer, Joan Hebeler, K Stenn, A Balin, T Higgins, J Stenn, Peyton Weary, John Reeves, Herbert Joseph, Alan Greenwald, San Jose, Ramon Fusaro, N Reply, Harvey Cohen, Philip Catalano, Victor Newcomer, Santa Monica, John Knox, David Fisher, Wilma Bergfeld, Robert Skinner, E Rosenberg, Maria Pucevich, Robert Kaplan, A Holshuh, N Reply, Emil Steinberger, Virginia Weiss, Dennis West, Catherine Mueller, Robert Baran, Joel Bernstein, Richard Grinzi, Harry Arnold, Rees Rees, Raul Fleischmajer, G Stephen Tint, Hugh Bennett, Douglas Nelson, Richard King, William Depietro, Carole Berger, Leonard Harber, Richard Edelson, Robert Adrian, George Murphy, Syozo Sato, Richard Granstein, Thomas Fitzpatrick, Arthur Sober, R Seville, Richard Dobson, Philip Nelson, Geo Yon Krogh, Stephen Estes, Larry Arlian, O Dayton, Stephen Uvr, Phillip Horwitz, Joseph Alper, David Silvers, Elson Helwig, Jeffrey Callen, Ruth Hanno, Miguel Botet, Francisco Ramos, Jorge Sfinchez, San Juan, Puerto Rico, Barbara Gilehrest, Nicholas Soter, Jeffrey Stoff, Martin Mihm, Ahmad Fathizadeh, John Rippon, Stewart Rosenfeld, David Fretzin, A Ahmed, Ronald Moy, A Barr, Zane Price, J Wedig, Robert Sayre, Deborah Desrochers, Carol Wilson, Edward Marlowe, Euan Mcmillan, Rose Wasik, Allen Everett, Oklahoma City, Isaac Zamora, Carlos Nunez, Chung-Hong Hu, E Eady, K Holland, W Cunliffe, Alan Shalita, Christopher Feucht, Bruce Alien
Journal: Journal of the American Academy of Dermatology (1981)
Radioisotope Therapy of Malignant Pleural and Peritoneal Effusions
Authors: Jan Bucerius, Hans-Jürgen Biersack
Journal: Clinical Nuclear Medicine (2020)

Treatment of malignant pleural or peritoneal effusions belongs to one of the "oldest" therapies with radioactive isotopes and was firstly described by J. H. Müller more than 50 years ago [1].
Personal Papers: Another exile in Oxford
Journal: BMJ (1983)

eeking for a suitable illustration to Dr Peter Meisner's article, we remembered that about 20 years beforehand the distinguished painter, Leonid Pasternak, had sought refuge in Oxford.His daughter, Josephine, who still lives in Oxford, kindly gave us permission to use a pastel of a scene on the outskirts of the city and has also written this note about her parents.-ED,BMJ
SCHOOLBOY MOSQUITO BRIGADES.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel cytomorphology of the giant proerythroblasts of parvovirus B19 infection
Authors: Prasad Rao Koduri
Journal: American Journal of Hematology (1998)

The morphology of the giant proerythroblasts (GPE) in air-dried and Wright-Giemsa-stained smears of bone marrow in 16 patients with pure red cell aplasia (PRCA) caused by parvovirus B19 infection is described. B19 infection was diagnosed by the presence of the virus or viral DNA and/or IgM antibodies. Twelve patients had chronic hemolytic anemia and aplastic crisis and 4 patients had AIDS with chronic PRCA. In patients with chronic hemolytic anemia and aplastic crisis, GPE were not detectable in bone marrow biopsies that showed any degree of recovery of erythropoiesis. The GPE morphology was quite variable. The early (basophilic) GPE measured 25 to 35 μm in diameter, had a narrow rim of intensely blue and often vacuolated cytoplasm with pseudopodia, round nuclei with compact uncondensed chromatin, and an indistinct and inclusion-like purple-colored tinctorial change. The "intermediate" and "late" GPE measured 25 to 45 μm in diameter and showed cytoplasmic swelling, gradual loss of cytoplasmic basophilia, and fraying of the cytoplasm with focal rupture; the nuclei showed an increase in volume, a highly uncondensed and coarse sieve-like chromatin, and 1 to 3 prominent, pale to moderate purple inclusion-like nucleoli or inclusions. Bare nuclei similar in size and chromatin pattern to those of the GPE were present in proximity to the GPE and may have arisen from the GPE by dissolution of the cytoplasm. The glassy intranuclear inclusions with central clearing, the so-called lantern cells described in formalin-fixed tissues of patients with B19 infection, were absent in all cases. These findings suggest that direct toxic cell injury rather than apoptosis may be involved in the pathogenesis of erythroid aplasia in B19 infection. Am. J. Hematol. 58:95–99, 1998. © 1998 Wiley-Liss, Inc.
Ultrasonic Doppler auscultation of the heart, with observations on atrial flutter and fibrillation
Authors: D. Abelson
Journal: JAMA (1968)

With an ultrasonic fetal heart detector, several low-frequency Doppler signals can be heard over the precordium. In normals, the characteristic pattern comprises atrial (a) ventricular systolic (β), and ventricular diastolic (8) components. During quiet breathing the β signal is usually loudest (β pattern), but on deep inspiration, lying, or squatting, the α signal predominates (α pattern). In atrial flutter or fibrillation the a signal disappears, and in some cases quivering noises (ψ signals) are audible. The Dopplercardiophone can also be useful at the bedside, in conjunction with the stethoscope, in elucidating gallop rhythm. Simultaneous recordings of the Doppler-cardiogram with electrocardiogram and phonocardiogram help to relate the signals to discrete cardiac events. The Doppler signals are probably mainly due to blood flow, movement of the heart wall, or both. The contribution of valve closure is relatively minor.