tbuckley/cabot-search huggingface dataset:
Highlights
Authors: Howard Bauchner
Journal: JAMA (2017)

Home Noninvasive Ventilation 2177Patients with chronic obstructive pulmonary disease who are hospitalized for respiratory failure, treated, and discharged to home are at risk for early rehospitalization to manage persistent hypercapnia.Murphy and colleagues conducted a randomized clinical trial of 116 patients with persistent hypercapnia following an acute exacerbation of chronic obstructive pulmonary disease and found that adding home noninvasive ventilation to home oxygen therapy prolonged the time to readmission or death.In an Editorial, Hill and Ugurlu compare these fi ndings with the results of other studies and suggest that a subset of patients with severe chronic obstructive pulmonary disease may benefi t from home noninvasive ventilation.Editorial 2167 CME jamanetwork.com/learning Predictions for Survival After an ICU Admission 2187Critically ill patients and their families often rely on physicians to help them anticipate the likelihood of death, poor cognition, and other adverse health outcomes.Detsky and colleagues conducted a prospective cohort study of 303 patients who required life support in the intensive care unit (ICU), fi nding that physicians' and nurses' discriminative accuracy in predicting 6-month outcomes depended on the outcome being predicted and the confi dence of the predictors.In an Editorial, Hall notes that prognostic studies may be dichotomous (life vs death) but in practice there is a continuum of possible prognoses, and this should be communicated to patients and their families in a qualitative way.
“Mast cells promote lung vascular remodelling in pulmonary hypertension.” J. Hoffmann, J. Yin, M. Kukucka, N. Yin, I. Saarikko, A. Sterner-Kock, H. Fujii, H. Leong-Poi, H. Kuppe, R.T. Schermuly and W.M. Kuebler.<i>Eur Respir J</i>2011; 37: 1400–1410.
Journal: European Respiratory Journal (2012)

Unfortunately, some elements of figures 1 and 2 of the above manuscript were published incorrectly.In the Volcano plot of figure 1a, the lines illustrating the boundaries for four-fold upregulated (Log2 .2) or downregulated (Log2 , -2) genes were incorrectly placed at +1.6 and -1.6 on the abscissa, rather than at +2 and -2.The error relates only to the pictorial representation of the Volcano plot and the quantitative data itself and its interpretation are not affected.
Antitumor activity of a human cytotoxic T-cell line (TALL-104) in brain tumor xenografts
Authors: Birgit Geoerger, Cheng-Bi Tang, Alessandra Cesano, Sophie Visonneau, Sunil Marwaha, Kevin D. Judy, Leslie N. Sutton, Daniela Santoli, Peter C. Phillips
Journal: Neuro-Oncology (2000)

Malignant glioma in adults and primitive neuroectodermal tumors/medulloblastomas in children are the most common malignant primary brain tumors that either respond poorly to current treatment or tend to recur.Adoptive therapy with TALL-104 cells-an IL-2-dependent, major histocompatibility complex nonrestricted, cytotoxic T-cell line-has demonstrated signi cant antitumor activity against a broad range of implanted or spontaneously arising tumors.This study investigates distribution of systemically and locally administered TALL-104 cells and their ef cacy in effecting survival of a rat model of human brain tumor.In vitro, TALL-104 cells showed signi cant cytotoxic activity when added to human glioblastoma cell lines U-87 MG, U-251 MG, and A1690; the medulloblastoma cell lines DAOY, D283 Med, and D341 Med; and the epidermoid cancer cell line A431.In brain tumor-bearing rats, the amount of uorescent dyelabeled TALL-104 cells in brain increased after they were given by intracarotid injection as compared with i.v.cell administration.However, TALL-104 cells rapidly decreased to low levels within 1 h after intracarotid injection.This nding suggests that TALL-104 cells given sys-temically may not invade brain or tumor tissues, but rather may remain in the vascular system, making this approach less ef cient for brain tumor treatment.In a model of athymic rats engrafted with human A431 carcinoma brain tumor, repetitive local administration of TALL-104 cells directly into the tumor bed resulted in a signi cant increase in survival time compared with control animals.Therefore, local therapy with TALL-104 cells may be a novel and highly effective treatment approach for malignant brain tumors.
Small-Intestinal Morphology in Infectious Hepatitis
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DEATHS OF PHYSICIANS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunohematology
Authors: Alan D. Schreiber
Journal: JAMA (1982)

DURING the past decade, a number of studies have been performed in an attempt to improve our understanding of the factors responsible for the immunologic destruction of blood cells. These studies, which have used quantitative immunologic techniques, have led to an improved understanding of the pathophysiology of autoimmune hemolytic anemia and immune thrombocytopenic purpura, and to a more precise understanding of the effector mechanisms that are operable in immunohematologic disease. These studies have helped to identify those patients in clinical, but not yet in immunologic, remission and have helped in the treatment of those patients with persistent immunologic disease. Furthermore, these studies have helped to elucidate the mechanism of action of corticosteroids in immunohematologic disease and have enabled the clinician to diagnose more readily and monitor patients with immunohematologic disease. Additionally, these studies have led to an increased understanding of the pathophysiology of a new entity: immunologic infertility. <h3>Immune Hemolytic</h3>
Opinions Differ.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Administrative accountability
Authors: B. J Golden
Journal: BMJ (2010)

<h3>Abstract</h3> <b>Overview of:</b> Black DM, Geiger EJ, Eastell MD, <i>et al</i>. Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates. <i>New Engl J Med</i>. 2020;383:743–753.
Blood Is Grouped, Typed by Automation At New York Red Cross Blood Donor Center
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA-RPS Takes Stand on Maternal-Fetal Conflict
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac Amyloidosis
Authors: C. Cristina Quarta, Jenna L. Kruger, Rodney H. Falk
Journal: Circulation (2012)

What Is Amyloidosis?Amyloidosis is a disease that occurs when a substance known as amyloid builds up in tissues and organs.Amyloid is formed from the breakdown of normal or abnormal proteins.The amyloid that is derived from these breakdown products deposits between the cells of one or more of the body's organs and interferes with the way the organs work.Deposits of amyloid in the heart cause the disease known as cardiac amyloidosis: as the deposits increase, the heart gets increasingly stiff and eventually the pumping function deteriorates.There are several types of amyloidosis, and the different forms are derived from different proteins.It is extremely important to determine the specific type of amyloid causing the disease, because each type of amyloidosis progresses at a different rate, and the treatment differs greatly for each form.Although amyloid can affect many organs of the body simultaneously, this overview specifically addresses the consequences and treatment of amyloid deposition in the heart.
Book Review Lane Medical Lectures: The lymphatic system; its part in regulating composition and volume of tissue fluid . By Cecil K. Drinker, Sc.D., M.D. Stanford University Publications, University Series. Medical Sciences, Vol. IV, Number 2. 4°, cloth, 101 pp., with 29 illustrations. Stanford University, California: Stanford University Press, 1942. $2.25 ($1.50 paper).
Journal: New England Journal of Medicine (1942)
Vital Signs: Preventing Antibiotic-Resistant Infections in Hospitals — United States, 2014
Authors: Lindsey M. Weiner, Scott K. Fridkin, Zuleika Aponte-Torres, Lacey Avery, Nicole Coffin, Margaret A. Dudeck, Jonathan R. Edwards, John A. Jernigan, Rebecca Konnor, Minn M. Soe, Kelly Peterson, L. Clifford McDonald
Journal: MMWR Morbidity and Mortality Weekly Report (2016)
Planning the Hospitals of the Future
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Bubble Boy'
Authors: D. Rennie
Journal: JAMA (1985)

David, the "Bubble Boy" was born on Sept 21, 1971. Because he had an even chance of developing severe combined immunodeficiency disease (SCID), the disease that had killed his brother, he was delivered by cesarean section into a sealed chamber. Frequent newspaper reports during the succeeding years described a growing David and ever-larger sterile plastic chambers—the "bubbles." A combination of extraordinary and imaginative technology, medical care by the team at Texas Children's Hospital and Baylor College of Medicine, as well as the devotion of his own family allowed David to remain free of contact with organisms and, so, free of disease. He celebrated his 12th birthday "with a family party, a chocolate cake and a Roman Catholic communion using a sterilized wafer" (<i>New York Times</i>, Sept 22, 1983, p A-14). He was the oldest "untreated" survivor of SCID. Despite transplantation on Oct 21, 1983, of bone marrow previously treated using
Highlights
Journal: JAMA Neurology (2019)

Although an estimated 7.5 million people worldwide are living with Parkinson disease (PD), the risks of developing PD are largely unknown.In a cohort study using claims from the Taiwan National Health Insurance Research Database covering approximately 23.5 million people from 2003 to 2013, Lin and coauthors found a reduced incidence of PD at 5-year follow-up in those with chronic hepatitis C virus (HCV) infection who received interferon-based antiviral therapy.The results support existing epidemiologic evidence of an association of HCV infection with PD and suggest that HCV infection is a risk of PD development and that early antiviral therapy may lower the risk of developing PD.Editorial perspective is provided by Ramirez-Zamora et al.
Abstract 18749: Body Mass Index, Leptin, and Recovery in Peripartum Cardiomyopathy: Results of the Multicenter IPAC Study
Authors: Esa Davis, Julie Damp, Rami Alharethi, Gregory Ewald, Michael Givertz, Biykem Bozkurt, John Boehmer, Hal Skopicki, Michael Felker, Marc Semigran, Karen Hanley-Yanez, Dennis M McNamara
Journal: Circulation (2015)

Introduction: The contribution of obesity and metabolic syndrome to the development of peripartum cardiomyopathy (PPCM) remains unknown. Leptin is a peptide hormone released by adipose tissue which may mediate impact of the obesity on cardiovascular function. We sought to evaluate their effect on myocardial recovery in PPCM in the multicenter Investigation of Pregnancy Associated Cardiomyopathy (IPAC) study. Methods: 100 women with new onset of PPCM were enrolled and serum obtained for biomarker analysis at entry. Myocardial function was assessed by echocardiography at entry, 2 months, 6 months and 12 months postpartum and LVEF calculated at a core lab. Leptin levels were measured by ELISA and the correlation of leptin with body mass index (BMI) and days post-partum evaluated. LVEF over the first year postpartum was compared by BMI at study entry (BMI &gt;30 versus&lt;=) and then compared by of Leptin levels (median). Results: The cohort was 30% black 65% white 5% other,age 30 + 6, mean BMI was 28.9 + 7.4 and LVEF 0.34 + 0.10 at study entry 31 + 25 days post-partum.Compared to those with a BMI&lt;=30 women with a BMI &gt; 30 had a similar LVEF at entry (LVEF BMI&gt;30 vs &lt; : 0.35 + 0.09 vs 0.34 + 0.10, p=0.60), but a lower LVEF at 2 month (0.39 + 0.12 vs 0.45 + 0.12, p=0.02), 6months (0.38 + 0.12 vs 0.53 + 0.09, p=0.02) and 12 months (0.50 + 0.13 vs 0.55 + 0.08, p=0.03). Leptin levels (mean 23.4 + 21.1 ng/ml, median 15.26 ng/ml) correlated with BMI (r=0.57, p&lt;0.001). Higher leptin levels were associated with more remodeling (LVEDD for high/low leptin= 5.8 + 0.7/5.4 + 0.6, p=0.02) at entry and lower LVEF 2months (high/low= 0.40 + 0.12/ 0.46 + 0.11, p=0.02) which persisted at 12 months (high/low= 0.51 + 0.11/0.56 + 0.08, p=0.03). Leptin levels were significantly lower at entry in subjects who subsequently recovered to an LVEF&gt;=0.50 (19.2 + 19.1 vs 31.8 + 22.9, p=0.006), and were higher in diabetics (p=0.01) and in blacks (p=0.03). Conclusions: In women with PPCM, obesity was associated with a lower LVEF at 6 and 12 months. Leptin levels correlated with BMI and were associated with greater LV remodeling at presentation and lower LVEF at 12 months. The impact of obesity and leptin on the development of cardiomyopathy warrants further investigation.
Finger wrinkling after immersion in water
Authors: G Alvarez
Journal: BMJ (1980)

cases, although in two female patients this was not obtained until necropsy.There were 19 female and two male patients, the mean age of presentation was 57 9 years, and seven patients (33%) were over the age of 65.These data reveal that in Tayside the annual incidence of primary biliary cirrhosis is 10-6 per million.On 31 December 1979 16 patients with the diagnosis were still alive, revealing the point prevalence as 40 2 per million.The incidence figure is almost twice that found by Dr Triger in Sheffield (5-8 per million), and by other workers in NE England (6-0 per million-as reported at the September
Essentials of Medical Electricity and Radiography.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: Clare Kunny-Rahn
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal