tbuckley/cabot-search huggingface dataset:
Multiple Markers for Lung Cancer Diagnosis: Validation of Models for Advanced Lung Cancer
Journal: JNCI Journal of the National Cancer Institute (1986)

Sera from 171 patients with advanced lung cancer, from 110 normals, and from 123 subjects with benign respiratory diseases were analyzed for 10 substances to detect lung cancer: ferritin, lipid-bound sialic acid, total sialic acid, β2-microglobulin, lipotropin, the alpha and beta subunits of human chorionic gonadotropin, calcitonin (two assays), parathyroid hormone, and carcinoembryonic antigen. Individual markers were studied, and optimal combinations of markers were sought for discriminating lung cancer patients from normals and from patients with benign lung disease. Numerous methods for combining the markers were examined, but the methods of logistic regression and recursive partitioning were finally adopted. The best discrimination rules we could find used only carcinoembryonic antigen (CEA) and total sialic acid (TSA). The performance of these rules was validated on an independent serum panel containing sera from 68 patients with advanced lung cancer, from 40 normals, and from 52 patients with benign respiratory disease. The combination rules based on TSA and CEA performed better than a rule based on CEA alone. Logistic discrimination rules with TSA and CEA that were designed to have 95% specificity achieved 54% sensitivity for discriminating advanced lung cancer from normal controls and 52% sensitivity for discriminating advanced lung cancer from controls with benign disease. Some aspects of clinical applicability are discussed, including planned studies for localized lung cancer and the requirement for further testing in specific clinical settings.
Phase II trial of combined chemotherapy with irinotecan, S-1, and bevacizumab (IRIS/Bev) in patients with metastatic colorectal cancer (mCRC): Final analysis—Hokkaido Gastrointestinal Cancer Study Group (HGCSG) trial.
Authors: Satoshi Yuki, Yoshito Komatsu, Hiraku Fukushima, Takahide Sasaki, Toraji Amano, Takuto Miyagishima, Kazuteru Hatanaka, Michio Nakamura, Miki Tateyama, Yuh Sakata
Journal: Journal of Clinical Oncology (2013)

460 Background: The FIRIS study (Muro K et al. Lancet Oncol 2010;11:853–860) previously demonstrated the non-inferiority of Irinotecan plus S-1 (IRIS) to FOLFIRI for mCRC, with progression-free survival (PFS) as the primary endpoint. We previously reported that IRIS plus bevacizumab (IRIS/Bev) is very effective as first-line treatment (Komatsu Y et al. Acta Oncol. 2012 May 4). We now report the final results of this study. Methods: Eligible patients had to have mCRC with a confirmed diagnosis of adenocarcinoma, an age of &gt;20 years, ECOG performance status (PS) of 0-1, and no history of prior chemotherapy. S-1 (40-60 mg depending on patients body surface area) was given orally, twice daily for 2 consecutive weeks, and 100 mg/m 2 irinotecan and 5 mg/kg bevacizumab was given intravenously on day 1 and 15, followed by 2-week rest period, within a 4-week cycle. The primary endpoint was safety. The secondary endpoints included overall response (OR), PFS, and overall survival (OS). Results: A total of 53 patients were enrolled from October 2007 through March 2009. The results were reported for 52 patients with evaluable lesions. The clinical characteristics of the patients were as follows. The median age was 63.5 years (range, 48 to 82). The male:female ratio was 3:2. The most common grade 3 or 4 adverse events were neutropenia (27%) and diarrhea (17%). Grade 3 or 4 hypertension (21%) was attributed to bevacizumab, but there were no life-threatening adverse events, such as gastrointestinal perforation. On an intention-to-treat basis, OR was 63.5% [95% confidence interval (CI) 50.4-76.5%], and the disease control rate was 94.2%. With a median follow-up time of 51.7 months, median PFS was 17.0 months (95%C.I. 14.2-19.8 months) and median survival time was 39.6 months (95%C.I. 34.2-45.0 months). Conclusions: IRIS/Bev is a remarkably active and generally well-tolerated first-line treatment for patients with mCRC. Randomized control trial comparing this regimen with oxaliplatin containing regimen(XELOX or mFOLFOX6 plus bevacizumab: TRICOLORE study) is already started. Clinical trial information: NCT00569790.
Cerebral Aneurysms
Authors: Jonathan L. Brisman, Joon K. Song, David W. Newell
Journal: New England Journal of Medicine (2006)

Saccular intracranial aneurysms cause substantial morbidity and mortality. Recently, major changes have occurred in the way we think about and treat this disease. This review discusses the percutaneous endovascular treatment of intracranial aneurysms as compared with surgical intervention. The technological advances and supporting research contributing to this important change in practice patterns are reviewed.
What the educators are saying
Authors: Phil Cotton, Jill Morrison
Journal: BMJ (2005)

What the educators are saying Three themes of professionalismMedical educators have focused a great deal of attention on professionalism in recent years without having a clear definition of the term.Researchers in Nijmegen attempted to define the term by reviewing and analysing the literature.They identified 90 elements of professionalism and described three main types of professionalism: interpersonal, public, and intrapersonal.They conclude that professionalism is a multidimensional concept, and they say that it is context dependent-in daily practice, doctors in one specialty will place more emphasis on some elements of professionalism than others.
Female predominance in chronic hepatitis C virus (HCV) infection with normal or minimally elevated transaminases . Gastroenterology Division, LSU School of Medicine, Shreveport* and New Orleans, LA
Journal: Hepatology (1995)

Hepatitis B virus (HBV) RNA in serum has recently been linked to efficacy and prognosis of chronic hepatitis B (CHB) treatment. This study explored the nature, origin, underlying mechanisms, and potential clinical significance of serum HBV RNA.The levels of HBV DNA and RNA were determined in the supernatant of induced HepAD38, HBV-expressing HepG2.2.15 cells and primary human hepatocytes (PHH), and in the serum of transgenic mice and CHB patients. NP-40 and proteinase K treatment, sucrose density gradient centrifugation, electron microscopy, northern blot, multiple identification PCRs and 5′ rapid-amplification of cDNA ends were performed to identify the nature of serum HBV RNA.Although significantly lower than HBV DNA levels, abundant HBV RNA was present in the serum of CHB patients. A series of experiments demonstrated that serum HBV RNA was pregenome RNA (pgRNA) and present in virus-like particles. HBV pgRNA virion levels increased after blocking the reverse transcription activity of HBV DNA polymerase, and decreased after blocking the encapsidation of pgRNA. Furthermore, the presence of HBV pgRNA virion was associated with risk of viral rebound after discontinuation of nucleot(s)ide analogues (NAs) therapy in CHB patients.Serum HBV RNA was confirmed to be pgRNA present in virus-like particles. HBV pgRNA virions were produced from encapsidated particles in which the pgRNA was non- or partially reverse transcribed. Clinically, HBV pgRNA virion might be a potential biomarker for monitoring safe discontinuation of NA-therapy.HBV may have another virion form in which the nucleic acid is composed of RNA, not DNA. The level of HBV RNA virion in serum may be associated with risk of HBV viral rebound after withdrawal of treatment, and therefore, a potential predictive biomarker to monitor the safe discontinuation of nucleot(s)ide analogues-therapy.
In Brief: Absorica for Acne
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
History
Authors: Ted W. Grace
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TYRANNY OF WORDS IN MEDICINE.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
Authors: Irene Sanjuan Nandin, Carol Fong, Cecilia Deantonio, Juan A. Torreno-Pina, Simone Pecetta, Paula Maldonado, Francesca Gasparrini, Jose Ordovas-Montanes, Samuel W. Kazer, Svend Kjaer, Daryl W. Borley, Usha Nair, Julia A. Coleman, Daniel Lingwood, Alex K. Shalek, Eric Meffre, Pascal Poignard, Dennis R. Burton, Facundo D. Batista
Journal: The Journal of Experimental Medicine (2017)
General Principles in Toxicology and Toxicologic Pathology
Journal: JNCI Journal of the National Cancer Institute (1987)

General Principles in Toxicology and Toxicologic Pathology Get access JNCI: Journal of the National Cancer Institute, Volume 78, Issue 4, April 1987, Page 785, https://doi.org/10.1093/jnci/78.4.785-b Published: 01 April 1987
Validation of the Lower Risk MD Anderson Prognostic Scoring System for Patients with Myelodysplastic Syndromes
Authors: Rami S. Komrokji, Maria Corrales-Yepez, Najla H Al Ali, Eric Padron, Ling Zhang, Pearlie K Epling-Burnette, Javier Pinilla-Ibarz, Jeffrey E Lancet, Alan F. List
Journal: Blood (2012)
In Reply
Authors: Thomas Büchner, Wolfgang E. Berdel, Claudia Schoch, Torsten Haferlach, Hubert L. Serve, Joachim Kienast, Susanne Schnittger, Wolfgang Kern, Joelle Tchinda, Albrecht Reichle, Eva Lengfelder, Peter Staib, Wolf-Dieter Ludwig, Carlo Aul, Hartmut Eimermacher, Leopold Balleisen, Maria Cristina Sauerland, Achim Heinecke, Bernhard J. Wörmann, Wolfgang Hiddemann
Journal: Journal of Clinical Oncology (2006)
Home Remedies
Authors: Floyd Skloot
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Novel BTB/POZ Transcriptional Repressor Protein Interacts With the Fanconi Anemia Group C Protein and PLZF
Authors: Maureen E. Hoatlin, Yu Zhi, Helen Ball, Kirsten Silvey, Ari Melnick, Stacie Stone, Sally Arai, Nicola Hawe, Gareth Owen, Arthur Zelent, Jonathan D. Licht
Journal: Blood (1999)
Not Guilty?
Authors: Dave Ellison
Journal: JAMA (1985)

It has been more than a year now since the jury returned its verdict of "not guilty." In that year, much of the emotional intensity of the experience has faded, but there still remains a strong, probably indelible set of impressions. Most are what you'd expect, even if you've never been sued for malpractice. I remember well the anger, the fear, the uncertainty, and the overwhelming unrelenting anxiety. I had expected all of that. What surprised me then, and even now, was the sense of isolation from my profession during the trial. My family was a safe haven. The defense attorneys were competent and concerned. With the exception of two acquaintances who had been sued themselves and two complete strangers who testified on my behalf, I received virtually no support, emotional or otherwise, from my physician colleagues. There were polite inquiries and equally polite expressions of concern, but for the
Perforation of atrium by polyethylene CV catheter
Authors: B. A. Friedman
Journal: JAMA (1968)

<h3>To the Editor:—</h3> In a recent article under the MEDICINE AND RELIGION section (<b>203</b>:65, 1967) Professor George Fletcher states that there is no case in the Anglo-American tradition in which a doctor has been convicted of murder or manslaughter for having killed to end the suffering of his patient. As an example, Professor Fletcher cites the murder trial of Dr. Hermann Sander who confessed to having injected air into an arm vein of a cancer-stricken patient. Professor Fletcher concludes the example with a statement as follows: "Nonetheless, the motive of mercy prompted the jury of laymen to acquit Dr. Sander." A more than cursory review of the case would reveal to Professor Fletcher that expert testimony at the trial by Dr. Richard Ford (at that time a member of the Department of Legal Medicine of the Harvard Medical School) clearly showed that an intravenous injection of air was impossible
Aphasia
Authors: Antonio R. Damasio
Journal: New England Journal of Medicine (1992)

APHASIA is a disturbance of the comprehension and formulation of language caused by dysfunction in specific brain regions. It results from a breakdown of the two-way translation that establishes a correspondence between thoughts and language. Patients with aphasia can no longer accurately convert the sequences of nonverbal mental representations that constitute thought into the symbols and grammatical organization that constitute language. One might say that the images or representations in thought can no longer be rendered in the words and sentences that appropriately translate them. The opposite process, the generation of internal imagery to match a sentence that is heard . . .
Trends in Urban Air Pollution in the United Kingdom in Relation to Lung Cancer Mortality
Authors: P. J. Lawther, R. E. Waller
Journal: Environmental Health Perspectives (1978)

The substantial reduction in air pollution, and particularly in components such as benzo[a]pyrene in urban areas of the United Kingdom during the past few decades has presented an opportunity to consider further the possible role of carcinogens in the air in relation to lung cancer. While the overall trends in lung cancer mortality have undoubtedly been dominated by changes in smoking, the marked contrasts that at one time existed between these death rates in urban and rural areas have gradually diminished. This may indicate that air pollution contributed appreciably to the urban/rural differences in lung cancer at one time, but it is still difficult to disentangle any effects it may have had from those of changing smoking habits.
Assay of Carcinogens
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Classification of students for physical education
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gender Differences in Time Spent on Parenting and Domestic Responsibilities
Authors: Toni Martin
Journal: Annals of Internal Medicine (2014)

Letters7 October 2014Gender Differences in Time Spent on Parenting and Domestic ResponsibilitiesToni Martin, MDToni Martin, MDFrom Berkeley, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5019-5 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Perhaps Jolly and colleagues (1) did not conclude that the observed differences in parenting were due to simple choice—as Cooke and Laine (2) did—because women, like men, make choices within a social context. Dr. Bennett, former Chief of Pediatrics at Harvard Community Health Plan, added a postscript to a “lighthearted” career article included in an anthology in 2002 that states, “In 1961, I was the brainwashed product of my culture's view of woman's place in society” (3). At the time, she believed that she was choosing to take primary responsibility at home. However, looking back, she saw ...References1. Jolly S, Griffith KA, DeCastro R, Stewart A, Ubel P, Jagsi R. Gender differences in time spent on parenting and domestic responsibilities by high-achieving young physician-researchers. Ann Intern Med. 2014;160:344-53. [PMID: 24737273] doi:10.7326/M13-0974 LinkGoogle Scholar2. Cooke M, Laine C. A woman physician-researcher's work is never done [Editorial]. Ann Intern Med. 2014;160:359-60. [PMID: 24737274] doi:10.7326/M14-0218 LinkGoogle Scholar3. Bennett DR. Postscript. In: Chin EL, ed. This Side of Doctoring: Reflections from Women in Medicine. Thousand Oaks, CA: Sage; 2002:31-2. Google Scholar Author, Article, and Disclosure InformationAuthors: Toni Martin, MDAffiliations: From Berkeley, California.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0212. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Woman Physician-Researcher's Work Is Never Done Molly Cooke and Christine Laine Gender Differences in Time Spent on Parenting and Domestic Responsibilities by High-Achieving Young Physician-Researchers Shruti Jolly , Kent A. Griffith , Rochelle DeCastro , Abigail Stewart , Peter Ubel , and Reshma Jagsi Gender Differences in Time Spent on Parenting and Domestic Responsibilities Ann Danoff Gender Differences in Time Spent on Parenting and Domestic Responsibilities Dena E. Rifkin , Nisha Bansal , and Esther K. Choo Gender Differences in Time Spent on Parenting and Domestic Responsibilities Reshma Jagsi Gender Differences in Time Spent on Parenting and Domestic Responsibilities Molly Cooke and Christine Laine Metrics 7 October 2014Volume 161, Issue 7Page: 533-534KeywordsConflicts of interestDisclosurePediatricsPrevention, policy, and public healthSexual identity ePublished: 7 October 2014 Issue Published: 7 October 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...