tbuckley/cabot-search huggingface dataset:
Impact of Homicide on Years of Potential Life Lost in Michigan's Black Population
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Critical care medicine
Authors: J. E. Parrillo
Journal: JAMA (1992)

Seven years ago, in the 1985 version of the Contempo series, I raised the question about whether critical care medicine had evolved sufficiently to be designated a true medical subspecialty.<sup>1</sup>The present statistics strongly support that it has. Critical care board certification examinations have been given since 1986 or 1987 in the four specialties of anesthesiology, internal medicine, pediatrics, and surgery. Through 1991, more than 4600 physicians have attained full certification, with the majority (&gt;2800) coming from internal medicine.<sup>2</sup>The total number of approved fellowship training programs has risen to 196, with internal medicine accounting for more than 100 of these programs. Within the field of internal medicine, critical care subspecialty training is represented as follows: pulmonary (70%), only critical care medicine (16%), cardiology (9%), nephrology (4%), and infectious disease (1%). As "grandfathering" accounted for most of the candidates for these examinations, this representation will probably change somewhat
LAW AND MEDICINE
Authors: Howard N. Morse
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toward better early-phase brain tumor clinical trials: A reappraisal of current methods and proposals for future strategies
Authors: Frederick F. Lang, Mark R. Gilbert, Vinay K. Puduvalli, Jeffrey Weinberg, Victor A. Levin, W.K. Alfred Yung, Raymond Sawaya, Gregory N. Fuller, Charles A. Conrad
Journal: Neuro-Oncology (2002)

Neuro-OncologyAlthough no optimal treatment is currently available for malignant brain tumors, as the molecular mechanisms underlying brain tumor development have been delineated, new chemotherapeutic agents that act directly on speci c molecular targets have become available.De ning a speci c molecular target raises the possibility that the molecular effects of a given agent can be analyzed in patients in a clinical trial.Speci cally, whereas standard phase I and II clinical trials classically determine the safety and ef cacy of agents by using indirect global end points, these new biological agents afford the opportunity to incorporate molecular end points into phase I and II clinical trials to determine whether the agent under investigation is actually doing what it was intended to do.This work presents avenues for improving current brain tumor clinical trial designs based on the molecular speci city of new agents and the unique features of brain tumors.Speci cally, the authors recommend brain-applicable phase I and II clinical trial strategies that take advantage of the targeted nature of new agents to maximize information about their ef cacy, toxicity, and molecular effects.
OF MIND AND STOMACH
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Etiology of upper-respiratory-tract illnesses among civilian adults
Authors: M. A. Mufson
Journal: JAMA (1966)

Virus infection was identified in 34% of 221 upperrespiratory-tract illnesses in adults. The single most important agents were the rhinoviruses. Rhinoviruses were recovered from 18% of 221 patients tested, and 82% of these patients had fourfold or greater rises in homologous antibody. Influenza A virus, parainfluenza virus type 1 or 3, or herpesvirus infection occurred in only 2% to 5% of patients, and infection with respiratory syncytial virus, adenovirus, parainfluenza virus type 2, and coxsackievirus A-21 occurred in less than 1% of patients. Thirty-one of the 40 rhinovirus strains could be identified serologically, and these belonged to 17 different serotypes. In this study the pattern of rhinovirus infection appeared to be that of a constantly changing mosaic involving different serotypes. No one serotype was predominant, and only six serotypes were detected more than once.
Lumleian Lectures on the Pathology of the Pneumogastric Nerve
Authors: S. O. Habershon
Journal: BMJ (1876)

IN this lecture, we pass on to the consideration of those pathological changes in the cesophagus, in the lungs, and in the heart, which are connected with disturbances of the par vagum; and we shall find fresh exemplification of the three laws upon wlhich we dwelt at our last lecture.I. Disease at the central origin of the nerve may induce symptoms of irritation in any other part supplied by the same nerve.2. Irritation in any set of peripheral branches may produce diisturbance in any other part to which the nerve is distributed, or in the centre itself.3. Alternation of irritation may be produced; at first one set of nerves, then another, becoming implicated.The aso/hag{us receives a large supply from the pneumogastric, and the branches of the nerve form a plexus upon it; but, besides these branches direct from the trunk of the nerve, others are derived from
Addition of an Author Affiliation
Authors: Sarah Ferguson, Kathleen Meert
Journal: JAMA Surgery (2021)

Randall S. Burd, MD, PhD; Aaron R. Jensen, MD, MEd, MS; John M. VanBuren, PhD; Rachel Richards, MStat; Richard Holubkov, PhD; Murray M. Pollack, MD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network Assessment of Health-Related Quality of Life and Functional Outcomes After Pediatric Trauma Investigators; Robert A. Berg, MD; Joseph A. Carcillo, MD; Todd C. Carpenter, MD; J. Michael Dean, MD; Barbara Gaines, MD; Mark W. Hall, MD; Patrick S. McQuillen, MD; Kathleen L. Meert, MD; Peter M. Mourani, MD; Michael L. Nance, MD; Andrew R. Yates, MD
Paganini
Authors: W. F. Spence
Journal: JAMA (1978)

<h3>To the Editor.—</h3> In his interesting article about Nicolo Paganini, Dr Schoenfeld describes how the artist lost his voice later in life and further suggested that this might have been due to enervation arising from his debilitated state. His chief theme, however, is that this was one of many indications that Paganini suffered from Marfan's syndrome and that some of his voice changes could have been due to recurrent laryngeal nerve impairment from an aortic aneurysm. Dubos and Dubos<sup>1</sup>also wrote about Paganini's health and thought that much of his trouble was due to tuberculosis. Besides having tuberculosis, Paganini was also syphilitic, which also might explain the musician's symptoms and behavior. Dubos and Dubos<sup>1</sup>describe the great effort that Paganini had to make to be heard at all, and he even brought his son on stage and had him announce to the audience information that he had whispered
Book Review Kinetic Bandaging including Splints and Protective Dressings: The kinetic method of visual teaching . By Seymour W. Meyer, M.S., M.D. 8°, cloth, 310 pp., with 540 illustrations. Philadelphia: F. A. Davis Company, 1943. $3.50. A History of Tufts College Medical School: Prepared for its semi-centennial 1893–1943 . By Benjamin Spector, M.D. 8°, cloth, 414 pp., with 49 illustrations. Boston: Tufts College Medical School Alumni Association, 1943. $5.00.
Journal: New England Journal of Medicine (1944)
Verapamil in Cardiac Arrhythmias
Authors: C. B. Boothby, C. S. Garrard, D. Pickering
Journal: BMJ (1972)

chest pain radiating to both arms and asso- ciated with sweating.The E.C.G. showed a sinus tachycardia with occasional supraventricular extrasystoles and an inferior in- farct.Serial serum transaminases were raised.The next day she developed a rapid atrial fibrillation for which she was digitalized.However, the dysrhythmia persisted 18 hours and 10 mg verapamil were given intravenously over a period of 20 seconds.Within 10 minutes, her cardiac rate had decreased from 180 per minute to 120 per minute.A tracing at this time showed a
Acute hypereosinophilic syndrome. Successful treatment with vincristine, cytarabine, and prednisone
Authors: E. J. Van Slyck
Journal: JAMA (1979)

WE describe here a young woman with hypereosinophilic syndrome (HES) who had a high peripheral WBC count, circulating early eosinophilic forms without blast forms, mental confusion with delusions bordering on coma, and severe cardiac manifestations. She successfully responded to a single course of vincristine sulfate, cytarabine, and prednisone therapy after high-dose prednisone therapy failed. <h3>Report of a Case</h3> A 31-year-old woman had a six-week history of weakness, night sweats, intermittent fever, occipitoparietal headaches, paresthesia, and dyspnea. Confusion, emotional lability, and severe heart failure had developed over the previous four days. History disclosed allergies to penicillin and aspirin, mescaline and LSD abuse, hepatitis eight years previously, and chronic asthma controlled adequately with an epinephrine inhaler. Noteworthy findings on physical examination included marked pallor, extreme lethargy, anterior cervical adenopathy, retinal hemorrhages, engorged breasts due to lactation, and pedal edema. Vital signs were normal except for a pulse rate of 100 beats per
Correction
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early discharge after surgery for breast cancer may be beneficial
Journal: BMJ (1998)

Early discharge after surgery for breast cancer may be beneficial Shorter hospital stays are a new trend in surgery.Bonnema et al (p 1267) studied the effects of early discharge from hospital after surgery for breast cancer in a randomised trial of 125 women.Satisfaction with the shorter stay was high, and the duration of drainage from the axilla and the incidence of wound complications did not differ in those who were discharged early and those who remained until their drain was removed.The experience of psychosocial problems was similar in the two groups, as were the coping strategies used.Women who had shorter hospital stays were more likely to discuss their illness with their family.
The Exchange
Authors: William A. Check
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplantation of multiple abdominal viscera
Authors: T. E. Starzl
Journal: JAMA (1989)

Two children with the short-gut syndrome and secondary liver failure were treated with evisceration and transplantation en bloc of the stomach, small intestine, colon, pancreas, and liver. The first patient died perioperatively, but the second lived for more than 6 months before dying of an Epstein-Barr virus—associated lymphoproliferative disorder that caused biliary obstruction and lethal sepsis. There was never evidence of graft rejection or of graft-vs-host disease in the long-surviving child. The constituent organs of the homograft functioned and maintained their morphological integrity throughout the 193 days of survival. (<i>JAMA</i>. 1989;261:1449-1457)
Chronic Bioassays of Chlorinated Humic Acids in B6C3F1 Mice
Authors: Benjamin L. Van Duuren, Susan Melchionne, Irving Seidman, Michael A. Pereira
Journal: Environmental Health Perspectives (1986)

Humic acids (Fluka), chlorinated to carbon:chlorine (C:Cl) ratios of 1:1 and 1:0.3, were administered to B6C3F1 mice, 50 males and 50 females per group, in the drinking water at a total organic carbon (TOC) level of 0.5 g/L.The mice were 6 to 8 weeks old at the beginning of the bioassays.The doses used were based on short-term (8 weeks) evaluations for toxicity, palatability, and weight gain.The chronic bioassays included the following control groups: unchlorinated humic acids (0.5 g/L), no-treatment (100 males and 100 females), dibromoethane (DBE, 2.0 mM in drinking water; positive control) and 0.44% sodium chloride in drinking water, i.e., at the same concentration as those receiving chlorinated humic acids.The chlor- inated humic acids were prepared freshly and chemically assayed once per week.All chemicals were, with the exception of DBE, administered for 24 months; DBE was administered for 18 months.The volumes of solutions consumed were measured once weekly.All treatment groups showed normal weight gain except the DBE group.At the completion of exposure, the animals were sacrificed and necropsied, and tissue sections were taken for histopathology.No markedly significant increases in tumor incidences were evident in any of the organs and tissues examined in the chlorinated humic acid groups compared to unchlorinated humic acids and the no-treatment control groups.DBE caused the expected high incidence of squamous carcinomas of the forestomach.The chlorinated humic acids tested contained direct-acting alkylating agents, based on their reactivity with p-nitrobenzylpyridine (PNBP), and showed mutagenic activity in S. typhimurium.
Clinical Rheumatology
Authors: Gerald P. Rodnan
Journal: JAMA (1971)

The Blue Bonnets have come over the border again, in the form of a volume designed to fill what is described as "a need... for a compact and concise account of rheumatic disorders for the interested clinician." The authors, who are affiliated with the Centre for Rheumatic Diseases and the Royal Infirmary in Glasgow, are to be congratulated—together with their publisher—for producing an eminently readable and generously illustrated volume which should prove useful to students at all levels. Drs. Boyle and Buchanan are to be admired for their boldness and fortitude in tackling what would nowadays ordinarily be a multiauthor work. Overall, the text is excellent, although, not unexpectedly, there are occasional statements which have gang agley. The reviewer must take exception, for example, to the contention (p 489) that "skin collagen [in progressive systemic sclerosis] does not appear to be present in increased amounts as judged by measurement of
Injection of Sodium Hypochlorite by Intravenous Drug Users
Authors: George W. Rutherford
Journal: JAMA (1987)

<h3>To the Editor.—</h3> A 5.25% solution of sodium hypochlorite (household bleach) effectively inactivates human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome.<sup>1-5</sup>Intravenous drug users who share needles are at high risk of acquiring and transmitting HIV, and cleaning needles and syringes with household bleach is being used as a strategy to control HIV transmission in this group.<sup>6,7</sup>The standard procedure includes flushing the syringe twice with undiluted household bleach and then twice with water. It has been suggested that toxic reactions following inadvertent injection of residual amounts of bleach in needles and syringes may be a possible reason for failure of this strategy. Although oral ingestion of household bleach is relatively nontoxic,<sup>8</sup>little is known about its parenteral toxicity. We report a case of nontoxic intravenous bleach injection in an intravenous drug user attempting suicide. <h3>Report of a Case.—</h3> A 27-year-old man, who had
Esophageal Cancer
Authors: Peter C Enzinger, Robert J Mayer
Journal: New England Journal of Medicine (2003)

Cancers arising from the esophagus, including the gastroesophageal junction, are relatively uncommon in the United States — the lifetime risk of this cancer is 0.8 percent for men and 0.3 percent for women, and it increases with age. The presentation is insidious; at diagnosis, more than 50 percent of patients have either unresectable cancer or radiographically visible metastases, rendering management problematic. This review discusses the pathogenesis of esophageal cancer, as well as the clinical presentation, treatment, and prognosis.
CAN ULTRASOUND IMAGING PREDICT THE DEVELOPMENT OF ACHILLES AND PATELLAR TENDINOPATHY? A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Sean Mc Auliffe, Karen Mc Creesh, Kieran O'Sullivan, Helen Purtill, Fiona Culloty
Journal: British Journal of Sports Medicine (2017)

<h3>Background</h3> Ultrasound [US] imaging is commonly used to visualise tendon structure. It is not clear whether the presence of structural abnormalities in asymptomatic tendons predicts the development of future tendon symptoms in the Achilles or patellar tendon. This led to considerable uncertainty in the management of sporting populations with a high prevalence of tendon related injuries. <h3>Objective</h3> To investigate the ability of US imaging to predict future symptoms of patellar or Achilles tendinopathy. <h3>Design</h3> A systematic review and meta-analysis. <h3>Setting</h3> Prospective imaging in a range of clinical settings. <h3>Patients (or Participants)</h3> The majority of the participants involved athletic populations ranging from volleyball, basketball, soccer players, fencing, badminton, ballet dancing, running. <h3>Interventions (or Assessment of Risk Factors)</h3> Prospective studies that performed US imaging of Achilles OR patellar tendon structure among asymptomatic subjects at baseline and a clinical measure of pain and/or function at follow-up were included. <h3>Main Outcome Measurements</h3> Tendon abnormalities were described as any deviation in tendon structure; e.g. hypoechogenicity, increased thickness, or increased vascularity as seen on power doppler US. <h3>Results</h3> The majority of participants in the review were from sporting populations. Meta-analysis revealed tendon abnormalities on US are associated with future symptoms of both patellar and Achilles tendinopathy [RR =4.97, 95% CI: 3.20–7.73]. Subgroup analysis indicated tendon abnormalities at baseline were associated with an increased risk of both Achilles [RR=7.33, 95% CI: 2.95–18.24] and patellar [RR=4.35, 95% CI: 2.62–7.23] tendinopathy. <h3>Conclusions</h3> This review indicates that tendon abnormalities US in asymptomatic tendons are predictive of future tendinopathy and are associated with at least a 4-fold increased risk. Identification of at risk athletes using screening tools such as US may allow preventative programs to be implemented. However, it is clear other factors beyond tissue structure are involved in the development of lower limb tendinopathy.