IDIOPATHIC HYPOPROTHROMBINEMIA
Authors: R A DESJARDINS, K E DROULARD
Journal: Annals of Internal Medicine (1950)

Case Reports1 August 1950IDIOPATHIC HYPOPROTHROMBINEMIAJEROME A. COVEY, M.D., JEROME L. COHEN, M.D., JEAN P. PAPPS, M.D.JEROME A. COVEY, M.D.Search for more papers by this author, JEROME L. COHEN, M.D.Search for more papers by this author, JEAN P. PAPPS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-2-467 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the description of the first case of idiopathic hypoprothrombinemia by Rhoads and Fitz-Hugh1in 1941, 11 additional cases have been reported. While these cases presented hypoprothrombinemia as the cardinal feature, they exhibited other findings which indicate the overlapping of disorders of bleeding tendencies. Because of the paucity of established instances in the literature and the known variations in the bleeding and clotting tests, some doubt has been raised as to the existence of idiopathic hypoprothrombinemia as a disease entity. As it was only in 1935 that an accurate method for the determination of plasma prothrombin was first developed by...Bibliography1. RhoadsFitz-Hugh JET: Idiopathic hypoprothrombinemia—apparently unrecorded condition, Am. J. M. Sc. 202: 662-670, 1941. CrossrefGoogle Scholar2. Beard MF, quoted by Quick: The hemorrhagic diseases and mechanisms of hemostasis, 1942, Charles C. Thomas, Springfield, Ill., p. 260. Google Scholar3. Giordano AS: Idiopathic hypoprothrombinemia, Am. J. Clin. Path. 13: 285-287, 1943. CrossrefGoogle Scholar4. MurphyClark FDJK: Idiopathic hypoprothrombinemia, Am. J. M. Sc. 207: 77-83, 1944. CrossrefGoogle Scholar5. AustinQuastler VTH: Idiopathic (?) hypoprothrombinemia, case, Am. J. M. Sc. 210: 491-500, 1945. CrossrefGoogle Scholar6. Hauser F: Familiäre Vitamin K resistente Hypoprothrombinämie, Ann. Paediat. 165: 142-148, 1945. MedlineGoogle Scholar7. de MarvalBomchil LG: Idiopathic hypoprothrombinemia, Semana med. 1: 1088-1092, 1944. Google Scholar8. de Marval L: Idiopathic hypoprothrombinemia, Semana med. 1: 476-477, 1945. Google Scholar9. Quick AJ: On the constitution of prothrombin, Am. J. Physiol. 140: 212-220, 1943. CrossrefGoogle Scholar10. MunroHartMunroWalking FLERMPAA: Changes in components A and B in dog following hepatectomy, Am. J. Physiol. 145: 206-210, 1945. CrossrefMedlineGoogle Scholar11. Seegers WH: Purification of prothrombin and thrombin; chemical properties of purified preparation, J. Biol. Chem. 136: 103-111, 1940. CrossrefGoogle Scholar12. LoomisSeegers ECWH: Is prothrombin a unitary principle or a complex, Am. J. Physiol. 148: 563-567, 1947. CrossrefMedlineGoogle Scholar13. EstrenMedalDameshek SLSW: Pseudohemophilia, Blood 1: 504-533, 1946. CrossrefMedlineGoogle Scholar14. Quick AJ: The components of prothrombin, Proc. Soc. Exper. Biol. and Med. 62: 249-250, 1946. CrossrefMedlineGoogle Scholar15. SeegersLoomisVandenbelt WHECJM: Isolation of prothrombin and its properties, Arch. Biochem. 6: 85-95, 1945. Google Scholar16. KarkLozner REL: Vitamin K deficiency in man; study of four non-jaundiced patients with dietary deficiency, Lancet 2: 1162-1163, 1939. CrossrefGoogle Scholar17. Mackie TT: Vitamin K deficiency in the absence of jaundice, N. Y. State J. Med. 40: 987-995, 1940. Google Scholar18. Owren PA: Parahemophilia—hemorrhagic diathesis due to absence of a previously unknown clotting factor, Lancet 1: 446-448, 1947. CrossrefMedlineGoogle Scholar19. Quick AJ: Congenital hypoprothrombinemia and pseudo hypoprothrombinemia, Lancet 2: 379-382, 1947. CrossrefMedlineGoogle Scholar20. ShapiroRichards SRK: Prothrombin response to large doses of synthetic vitamin K in liver disease, Ann. Int. Med. 22: 841-851, 1945. LinkGoogle Scholar21. Plum P: Idiopathic hypoprothrombinemia refractory to vitamin K, Acta med. Scandinav. 113: 262-265, 1943. CrossrefGoogle Scholar22. Quick AJ: The coagulation of the blood: theoretical and practical aspects, Proc. Inst. Med. Chicago 16: 94-106, 1946. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Jamaica, L. I., N. Y.*Received for publication April 13, 1948.From the Department of Medicine, James R. Reuling, M.D., Director, Queens General Hospital, Jamaica, L. I., N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCongenital Idiopathic HypoprothrombinemiaBeiträge zur Pathologie der BlutgerinnungAngeborener Faktor V-Mangel. (Owrensche Krankheit)Die hämophilie-ähnlichen hämorrhagischen DiathesenBlood Grouping, Blood Banking and Blood Transfusion 1 August 1950Volume 33, Issue 2Page: 467-473KeywordsBlood plasmaHemorrhageHospital medicine ePublished: 1 December 2008 Issue Published: 1 August 1950 PDF downloadLoading ...