tbuckley/cabot-search huggingface dataset:
Military medicine prepares health and safety tips for those serving in Somalia, requests feedback
Authors: P. Gunby
Journal: JAMA (1993)

TEMPERATURES WILL climb into the 30s Centigrade (high 80s Fahrenheit) this month in Somalia. Military physicians are cautioning US troops there that "effects of the hot environment in this area are worsened by high humidity, making the heat significant even for the indigenous people." That reminder is found in<i>Staying Healthy in Somalia: Preliminary Recommendations</i>, a pocket-sized booklet swiftly prepared by the Preventive Medicine Consultants Division, Office of the Surgeon General of the US Army, for use as Operation Provide Hope got under way (<i>JAMA</i>. 1993;269:11-12). At least two other booklets have been prepared just as promptly. One is<i>Sustaining Soldier Health and Performance in Somalia: Guidance for Small Unit Leaders</i>, prepared by the US Army Research Institute of Environmental Medicine, Natick, Mass, and Walter Reed Army Institute of Research, Washington, DC, for the Army Medical Research and Development Command, Fort Detrick, Md. The other is<i>Operation Restore Hope: Health</i>
The Future of General Surgery
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Concussion
Authors: Christina L. Master, Andrew R. Mayer, Davin Quinn, Matthew F. Grady
Journal: Annals of Internal Medicine (2018)

Concussions are a common injury for which patients often present first to primary care physicians. They can affect the day-to-day function of patients in school and work, as well as in sports and recreational activities. Recognizing common physical signs and symptoms after injury facilitates timely diagnosis and treatment, permitting initiation of an active management approach to recovery while preventing secondary injury. For persons with persistent symptoms, active rehabilitation may be utilized, with the goal of returning patients to full function.
The World's Best Doctor Stories
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CARDIATION.
Authors: EPHRAIM CUTTER
Journal: JAMA (1898)

Cerebration is a general term for the functions of the cerebrum and cerebellum. Manipulation means the functions of hands, and the writer thinks that it would be well if cardiation and its fellow, cardiate, were commonly used. The heart is an autonomy like the brain, eye, ear, epithelium, etc. Indeed, some concede autonomy to every cell in the human body. Hence it is modest to claim autonomy for the heart on general principles for the following reasons: The heart has nerves enough of its own to run it. Some three hundred years ago a Dutch anatomist executed a life-size copper engraving of the cardiac ganglionic nerve centers. The heart was covered with white ganglia about half an inch in diameter, connected with radiating nervefibers, like streets or railways between cities. While a medical student, I killed a fresh-water snapper turtle of about thirty pounds weight. The heart, entirely removed, beat
Zicam Update
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serial Sevens
Authors: Jessica Frey
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Attempt to Suppress Excessive Growth in Girls by Estrogen Treatment: Statistical Evaluation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Healthy Respect for the Word
Authors: Morgan Martin
Journal: JAMA (1978)

Here we are, physicians Prescribing from our shelves Devising our scenarios Writing out ourselves Here we are, plain patients Part of your daily rounds Sifting every utterance Hanging on your sounds. THE PHYSICIAN treats with words; within the physician-patient social system, the patient is moved by fears and other sentiments, and these are modified by the physician's words and phrases.<sup>1</sup>Physicians dispense not only medicines but words that influence medicines or, all by themselves, that affect the patient more than the medicine.<sup>2</sup> Physicians use words in various ways. They use them as tools to uncover diagnosis and as vessels to carry treatment and caring. As the physician explores the human condition, his English may be more meaningful than his biology or neurology. Does the physician listen to his own words as carefully as those of the patient? Does he seek the best word, the best phrase, or the
Glib Glossary
Authors: Wilma Reeve
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Validation of a genomic classifier that predicts metastatic disease progression in men with biochemical recurrence post radical prostatectomy.
Authors: Ashley E. Ross, Mercedeh Ghadessi, Elai Davicioni, Anamaria Crisan, Christine Buerki, Nicholas Erho, Anirban Pradip Mitra, Darby J. S. Thompson, Timothy J. Triche, Edward M Schaeffer, Felix Yi-Chung Feng
Journal: Journal of Clinical Oncology (2013)

52 Background: The majority of the 29,000 men who die annually from prostate cancer present initially with localized disease and develop biochemical recurrence (BCR) following radical prostatectomy (RP). While the post-RP recurrence group of patients is highly enriched for those who will develop lethal disease, many of these patients will experience BCR without subsequent metastases. Thus, there is a clear need to improve patient risk stratification in this context. Here, we evaluate Decipher, a genomic classifier (GC) in men with BCR for its ability to predict metastasis. Methods: The 22-feature GC model was validated in a prospectively designed case-cohort study of a clinically high-risk population of 1,010 RP patients treated at Mayo Clinic between 2000-06. A random sample of 20% of this population was subjected to microarray analysis and GC scores were generated for 219 patients, including 110 who developed BCR post RP. The c-index for predicting metastatic disease progression (i.e., positive bone or CT scans), Cox modeling, decision curves and multivariable analyses were used to compare the performance of GC to Gleason score (GS), PSA doubling time (PSAdT) and time to BCR (ttBCR). Results: The c-index for predicting metastatic disease progression 3 years after BCR was 0.82 (95% CI, 0.80-0.90) for GC, which compared favorably to GS 0.65 (0.54-0.69), PSAdT 0.60 (0.62-0.78) and ttBCR 0.54 (0.64-0.81). Decision curve analysis showed that GC had a higher overall ‘net benefit’ compared to GS, PSAdT and ttBCR for risk of metastasis. Cumulative incidence of metastasis 3 years after BCR was 9% versus 43% (p&lt;0.001) for patients with low and high GC scores, respectively. In multivariable modeling with clinicopathologic variables, GC (p&lt;0.001) and GS (p=0.02) scores remained the only significant predictors of metastasis. Conclusions: When compared to clinicopathologic variables, GC better predicted metastatic progression among our cohort of men with BCR following RP. While confirmatory studies in additional patient populations are required, these results suggest that use of GC can allow for better selection of men requiring additional treatment at the time of BCR.
An Introduction to the Theory and Use of the Microscope.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methodological Problems Arising from the Choice of an Independent Variable in Linear Regression, with Application to an Air Pollution Epidemiological Study
Authors: Inge F. Goldstein, Joseph L. Fleiss, Martin Goldstein, Leon Landovitz
Journal: Environmental Health Perspectives (1979)

In epidemiological studies using linear regression, it is often necessary for reasons of economy or unavailability of data to use as the independent variable not the variable ideally demanded by the hypothesis under study but some convenient practical approximation to it. We show that if the correlation coefficient between the "practical" and "ideal" variables can be obtained, then a range of uncertainty can be obtained within which the desired regression coefficient of dependent on "ideal" variable may lie. This range can be quite wide, even if the practical and ideal variables are fairly well correlated. These points are illustrated with data on observed regression coefficients from an air pollution epidemiological study, in which pollution measured at one station in a large metropolitan area (containing 40 aerometric stations) was used as the practical approximation to the city-wide average pollution. The uncertainties in the regression coefficients were found to exceed the regression coefficients themselves by large factors. The problem is one that may afflict application of linear regression in general, and suggests caution when selecting independent variables for regression analysis on the basis of convenience, rather than relevance to the hypotheses tested.
Error in Byline
Journal: JAMA Psychiatry (2014)

Ronny Redlich, MA; Jorge R. Almeida, MD, PhD; Dominik Grotegerd, MSc; Nils Opel; Harald Kugel, PhD; Walter Heindel, MD; Volker Arolt, MD, PhD; Mary L. Phillips, MD, MD(Cantab); Udo Dannlowski, MD, PhD
EMBR-09. EMBRYONAL TUMOR WITH MULTILAYERED ROSETTES: THE MD ANDERSON CANCER CENTER EXPERIENCE
Authors: Nelda Itzep, Wafik Zaky, Citla Sridhar, Bhanu Gogia, Heather Meador, Sheetal Phadnis, David Sandberg, Greg Fuller, Leena Ketonen, Soumen Khatua
Journal: Neuro-Oncology (2018)

Embryonal Tumor with Multilayered Rosettes (ETMR) is a rare tumor of the central nervous system (CNS) with poor prognosis. To date no defined robust treatment strategy or advanced brain tumor imaging (ABTI) have been described for these malignancies. We performed a retrospective analysis and identified 8 pathology-proven ETMR cases from 2010–2017 treated at our institution, and evaluated our institutional experience, including imaging characteristics. Age ranged from 1.11 to 12.8 years. Tumors were located in the brainstem, spine, and frontal lobes. Presenting signs varied, and included cranial nerve and cerebellar dysfunction, cord compression and proptosis. Treatment included a combination of surgery, chemotherapy and radiation. The neuroimaging profile showed heterogeneous enhancement with minimal or no perilesional edema, and restricted diffusion. Magnetic resonance spectroscopy (MRS) demonstrated a choline/creatinine ratio greater than 2, depressed N-acetylaspartate (NAA), low myo-inositiol (in intermediate echo) and lipid/lactate peaks, typical for high-grade neoplasm. Diffusion tensor imaging (DTI) revealed deviated corticospinal tracts, with no evidence for tumor infiltration. Next generation sequencing assay failed to identify druggable mutations. Improved methods for early diagnosis of ETMR are evolving, most notably LIN28A immunostaining and 19q13.42 amplification detection. Though pre-operative MRI scans have been performed, advanced brain tumor imaging (ABTI), including MRS and DTI, have not been routinely reported in the ETMR literature. Prospective studies of these biologically elusive rare tumors should include, in addition to molecular characterization, neuroimaging with ABTI, which could aid diagnosis, surgical planning and follow-up of treatment response.
Errors in Table.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2735: Targeting HDAC prevents smoking-induced pancreatic cancer metastasis
Authors: Jiyong Yang, Chintan Chheda, Dina Hauptschein, Latifa Zayou, Josiah Tang, Qiang Wang, Stephen J. Pandol, Mouad Edderkaoui
Journal: Cancer Research (2019)

Abstract Background: Cigarette smoking is an established risk factor for pancreatic ductal adenocarcinoma (PDAC). Among patients with metastatic PDAC, 90% have liver and 50% have lung metastasis. In this project we investigated the effect of smoking on pancreatic cancer invasion and metastasis in vitro and in vivo. Methods: Pancreatic cancer cells were treated with different doses of 4-(methylnitro-s-amino)-1-(3-pyridyl)-1-butanone (NNK) and cigarette smoke extract (CSE) and cancer cell survival, markers of epithelial to mesenchymal transition (EMT) as well as invasion were measured by MTT assay, Western, RT-PCR and Matrigel Invasion Assay. In a syngeneic mouse model of pancreatic cancer mice were pre-treated with NNK for 4 weeks and mouse cancer cells were injected in the spleen of mice. Progression of the disease including metastasis to liver and lung was monitored by imaging and tissues were collected and analyzed after 6 weeks. Results: Smoking compounds slightly but significantly increased cancer cell survival. They significantly promoted expression of EMT markers and promoted invasion of the cancer cells. Inhibition of histone deacetylase (HDAC) (class I and II), and especially HDAC4, prevented the pro-EMT and invasion effect of smoking compounds. NNK increased the protein level of HDAC4 and the level of Yes-associated protein 1 (Yap) translocated to the nucleus. Inhibition of HDAC4 reversed this effect. Analysis of Yap binding proteins showed presence of HDAC4 in the Yap protein complex. HDAC inhibition decreased the level of Yap-HDAC4 complex formation. In vivo, NNK promoted metastasis of pancreatic cancer cells to mice lung and liver; whereas, inhibition of HDAC decreased the number of metastases to a level lower than control treated mice. Smoking promoted liver and lung fibrosis and inflammation and measured by the level of collagen staining, stellate cells activation and immune cells staining. HDAC inhibition reversed these effects of smoking. Conclusion: We showed for the first time in an animal model that smoking promotes metastasis of PDAC to the lung. We found that HDAC4 is key mediator of this effect. Inhibiting HDAC4 is a promising strategy for preventing PDAC metastasis. Citation Format: Jiyong Yang, Chintan Chheda, Dina Hauptschein, Latifa Zayou, Josiah Tang, Qiang Wang, Stephen J. Pandol, Mouad Edderkaoui. Targeting HDAC prevents smoking-induced pancreatic cancer metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2735.