tbuckley/cabot-search huggingface dataset:
Adoptive transfer of immunity to hepatitis B virus in mice by bone marrow transplantation from immune donors
Authors: D Shouval
Journal: Hepatology (1993)

Recipients of allogeneic bone marrow transplantation are immunosuppressed as a result of their primary disease and by myeloablative therapy. Such patients are dependent on multiple blood products and are at risk for hepatitis B virus infection. Active immunization against hepatitis B in the immediate pre- and post-transplant periods is ineffective, pre- sumably because of decreased T cell–dependent B-cell responses. This study was designed to evaluate, in a mouse model system, the transfer of immunity against hepatitis B to bone marrow transplant recipients through immunization of bone marrow donors against hepatitis B before transplantation. Bone marrow donor BALB/c mice were immunized with a recombinant hepatitis B vaccine. Seroconversion to HBs antibody occurred within 4 wk of primary immunization, and antibody levels in treated donor mice rose above 300 mIU/ml after a single booster injection. Bone marrow recipient mice, conditioned by sublethal irradiation, were injected intravenously with bone marrow cells obtained from syngeneic HBs antibody–positive immune donors. Antibody was detected in 10% of bone marrow recipients within 30 days of transplantation and in 56% 1 mo after a booster injection that led to a secondary rise in HBs antibody. Adoptive transfer of immunity to hepatitis B also occurred after transplantation of T cell–depleted bone marrow cells from hepatitis B–immune donors, albeit at a lower HBs antibody level. These results indicate that immunity to hepatitis B can be transferred in mice by bone marrow transplantation from hepatitis B–immune donors to immunosuppressed recipients. Furthermore, such bone marrow transplant recipients were able to respond to a booster immunization, suggesting secondary immune response in bone marrow recipients after primary response in donors. These data support the rationale for active vaccination of potential human bone marrow donors against hepatitis B, followed by booster vaccination to bone marrow recipients. (HEPATOLOGY 1993;17:955–959.)
THE ANNUAL ADDRESSES.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival outcomes for young men with localized intermediate-risk prostate cancer: An analysis of the NCDB.
Authors: Graham Boyd, Muhammad M. Qureshi, Gretchen Gignac, Ariel Hirsch
Journal: Journal of Clinical Oncology (2018)

e17085 Background: There is no consensus on the optimal treatment of localized, intermediate-risk prostate cancer, especially in patients diagnosed at a young age with extended life expectancies. Primary management consists of a radical prostatectomy (RP), radiation therapy alone (RT), or radiation therapy with short course androgen deprivation therapy (RT+ADT). The purpose of this study was to determine if these treatment strategies have equivalent overall survival (OS) in patients < 55 years old with intermediate-risk prostate cancer. Methods: From 2010-2013, we identified 13,711 patients < 55 years old in the NCDB with localized, intermediate-risk prostate cancer treated with RP, RT, or RT+ADT. Characteristics assessed included age, race, insurance type, Charlson-Deyo score (CDS), number of intermediate-risk criteria, and treatment type. The primary outcome of the analysis was OS. 3-year survival rates were estimated using the Kaplan-Meier method. Adjusted hazard ratios (HR) with 95% confidence intervals (CI) were computed using multivariate (MVA) Cox regression. Results: 11,737 (85.6%) patients received RP, 1,495 (10.9%) received RT, and 479 (3.5%) received RT+ADT. Median (interquartile range) patient age was 52 years old (49-53 years), median follow up was 36.3 months (23.8-49.5 months), and median RT dose was 76 Gy in 29 fractions. 3-year OS was estimated to be 99.2% for RP, 98.0% for RT+ADT, and 97.5% for RT (p < 0.001). On MVA, treatment with RT alone was associated with significantly worse OS compared to treatment with RP (HR = 1.77, 95% CI 1.23-2.54, p = 0.002). There was no significant difference noted in OS between treatment with RP and RT+ADT (HR = 1.59, 95% CI 0.91-2.78, p = 0.105). The number of intermediate-risk criteria met had no impact on OS. Conclusions: RP is significantly more likely than RT or RT+ADT to be used as a primary treatment for young men in localized, intermediate risk prostate cancer. RP was also associated with improved 3-year OS when compared to RT alone, but does not confer better outcomes compared to RT+ADT. The survival benefit of RP over RT alone should be considered when planning treatment for intermediate-risk patients in this age group.
Commentaire de travail de Goetz M et al., pp. 469
Journal: Endoscopy (2013)

See also:In vivo molecular imaging with cetuximab, an anti-EGFR antibody, for prediction of response in xenograft models of human colorectal cancerEndoscopy 2013; 45(06): 469-477DOI: 10.1055/s-0032-1326361
What's the Connection? No Easy Answers for People With Eating Disorders and Drug Abuse
Authors: B. Vastag
Journal: JAMA (2001)

New York—For therapist Steven Levenkron, MS, "I know what I'm doing" is more than an angry retort uttered by many of the patients with eating disorders he treats. It's a glimpse into the distorted thinking that signals when the illness has sunk to its nadir.
The Snowman
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AIDS Associated With Injecting-Drug Use— United States, 1995
Journal: JAMA (1996)

Injecting-drug use is the second most frequently reported risk behavior for infection with human immunodeficiency virus (HIV). As of December 31, 1995, of 513,486 cases of acquired immunodeficiency syndrome (AIDS) reported to CDC, 184,359 (36%) were directly or indirectly associated with injecting-drug use. Injecting-drug-user (IDU)-associated AIDS cases include persons who are IDUs (n = 161,891), their heterosexual sex partners (n = 18,710), and children (n = 3,758) whose mothers were IDUs or sex partners of IDUs. This report characterizes persons with and trends in IDU-associated AIDS reported to CDC through 1995 from the 50 states, the District of Columbia, and the U.S. territories.
Essentials of Nutrition
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Election of Lord Rector of University of Glasgow
Journal: BMJ (1840)

A YOUNG girl, 18 years of age, had complained for the last twelve months of pain in the hypogastric region, and pTresented all the symptoms of a large vesical calculus.The-patient was unable to sit down without taking the greatest care, and was obliged to use a chair made par- ticularly for her.She was sounded, and the existence of a calculus became evident.M. Delmas performed the ope- ration of lithotrity on the 2d of May, and repeated it four times during the month.A great quantity of detritus was discharged with the urine, biit the sufferings of the patient remained unabated.M. Delmas, therefore, suspected that some foreign body must have been introduced into the blad- der, and at length discovered that the girl had, a year back, introduced into the urethra the handle of a steel-pen.The form of the instrument employed in the operation was now ehanged, and on using it again the nucleus, or pen-handle, was cut in two and extracted, though with considerable difficulty, and after eight or nine "sittings."The patient soon recovered.-
The War Surgeon
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In memoriam of David P. Rall.
Journal: Environmental Health Perspectives (1999)

As a scientist, administrator, and diplomat, David P. Rall pioneered the effort to identify and understand the elements that make up the human environment and their consequences for human health. As an intellectual and aggressive activist, he educated scientists, governments, and the world community to the critical need to address the existence of environmental agents and their consequences for human health. As a leader he marshalled some of the best minds and hearts of his time to the cause of world health through a safe and clean environment. And as a visionary he provided the goals of environmental health science and the direction to guide both current and future generations. His death on September 28 brought to a close a chapter in the evolution of our understanding of the interconnectedness of human health and the environment, a chapter he was largely responsible for writing.
The case of the "beeping" heart
Authors: F. K. Nakhjavan
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The extracardiac origin of chest sounds synchronous with heart beat is well established. Most of the reported cases have had supradiaphragmatic pathologic conditions, ie, mediastinal emphysema, pneumothorax, lung interstitial emphysema, pneumopericardium, air embolism, and hiatus hernia.<sup>1</sup>Recently we examined a patient with an unusual chest sound, which was easily heard several feet away from the patient, in whom the gas bubble in splenic flexure seemed to be the cause. <h3>Report of a Case:—</h3> The patient was 10 years old, and she had been referred because of a murmur discovered four months previously during the course of an apparently insignificant gastrointestinal tract illness. However, for approximately nine months the patient had been aware of a phenomenon which she described quite simply: "I beep." The parents also had noted the sound and described it as "like a radio signal." It could be heard from a distance, occurred at
Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of β-oxidation in insulin secretion
Authors: Peter T. Clayton, Simon Eaton, Albert Aynsley-Green, Mark Edginton, Khalid Hussain, Steve Krywawych, Vipan Datta, Helga E.M. Malingré, Ruud Berger, Inge E.T. van den Berg
Journal: Journal of Clinical Investigation (2001)

A female infant of nonconsanguineous Indian parents presented at 4 months with a hypoglycemic convulsion. Further episodes of hypoketotic hypoglycemia were associated with inappropriately elevated plasma insulin concentrations. However, unlike other children with hyperinsulinism, this patient had a persistently elevated blood spot hydroxybutyrylcarnitine concentration when fed, as well as when fasted. Measurement of the activity of L-3-hydroxyacyl-CoA dehydrogenase in cultured skin fibroblasts with acetoacetyl-CoA substrate showed reduced activity. In fibroblast mitochondria, the activity was less than 5% that of controls. Sequencing of the short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) genomic DNA from the fibroblasts showed a homozygous mutation (C773T) changing proline to leucine at amino acid 258. Analysis of blood from the parents showed they were heterozygous for this mutation. Western blot studies showed undetectable levels of immunoreactive SCHAD protein in the child's fibroblasts. Expression studies showed that the P258L enzyme had no catalytic activity. We conclude that C773T is a disease-causing SCHAD mutation. This is the first defect in fatty acid β-oxidation that has been associated with hyperinsulinism and raises interesting questions about the ways in which changes in fatty acid and ketone body metabolism modulate insulin secretion by the β cell. The patient's hyperinsulinism was easily controlled with diazoxide and chlorothiazide.
SP0149 New trends in biomarkers in inflammatory joint diseases
Authors: E Feist
Journal: Annals of the Rheumatic Diseases (2017)

This lecture provides an overview on new developments in biomarker research and standardization in inflammatory joint diseases. The presentation includes an introduction of established and new biomarkers in serum and synovial fluid as well as methods for their detection. Furthermore, an overview on different modifications of auto-antigens (including citrullinated and carbamylated isoforms) and their role in immune response and pathogenesis of disease will be given. The diagnostic performance of new and established biomarkers will be discussed including antibodies against modified antigens also illustrated by difficult to diagnose cases. In this context, special attention will be attributed to the predictive value of biomarkers for diagnosis of disease and treatment response. <h3>Disclosure of Interest</h3> None declared
American Academy of Clinical Toxicology
Authors: Eric G. Comstock
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The American Academy of Clinical Toxicology has been founded for the advancement of clinical toxicology, a medical specialty concerned with the diagnosis and treatment of poisoning and drug intoxication. The purposes of the academy are to encourage clinical investigation, to promote the development of diagnostic and therapeutic methods, to foster among practicing physicians a better understanding of the treatment of poisoning, and to improve the medical care received by the poisoned patient. An organizational meeting is planned for Oct 22, 1968, 9 am to 12 noon, at the Drake Hotel, Chicago. Applications for charter membership and further information may be obtained from the acting secretary-treasurer, American Academy of Clinical Toxicology, Box 2565, Houston 77001.
Editor's Note: Growth Inhibitory and Antimetastatic Effect of Green Tea Polyphenols on Metastasis-Specific Mouse Mammary Carcinoma 4T1 Cells <i>In vitro</i> and <i>In vivo</i> Systems
Authors: Manjeshwar S. Baliga, Sreelatha Meleth, Santosh K. Katiyar
Journal: Clinical Cancer Research (2018)
Vagabond's diabetes
Authors: R. Miller
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The use of "flaunt" for "flout" inThe Journal(<b>215</b>: 1481, 1971) reminded me of verses I wrote when, several years ago, the<i>Des Moines (Iowa)</i><i>Register</i>displayed a parade of pickets marching around the university in Iowa City. One banner carried by a fulltime marcher Walter Gormly read, "U. S. Army Flaunts Justice." This caused me to burst into verse: Oh Gormly, brother Gormly, You protest far too warmly. Most thoughtful people have grave doubts Of those who can't tell flaunts from flouts. Justice is what the Army wants And waves about, as you say, "flaunts." Men when they picket or parade Should watch how their displays are made Lest they reveal themselves as louts By flouting flaunts, not flaunting flouts. These crossovers along with militate-mitigate and affect-effect confusion lies just about at the borderline between human comprehensibility and the never-never land where control of language
Party Alert: Here’s Foam in Your Eye
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival of patients with AIDS depends on physicians' experience treating the disease
Authors: J. Stephenson
Journal: JAMA (1996)

HOW LONG HIV-infected patients live after they're diagnosed with AIDS depends to a surprising degree on whether their physicians have even a modest amount of experience in treating the disease. New research reported at the Third Annual Conference on Retroviruses and Opportunistic Infections in Washington, DC, found that people with AIDS whose therapy was managed by primary care physicians with no previous experience in treating such patients died more than a year sooner than those whose physicians had previously treated at least five patients. Even people whose physicians had treated only a handful of patients lived 7 months longer. Previous studies found lower mortality rates among patients who were treated at hospitals that cared for greater numbers of patients with AIDS-related conditions, suggesting that the experience gained in treating larger numbers of patients may lead to better management strategies and patient outcomes. Given this apparent relationship between experience and patient
Depression
Authors: Judith Skillman
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Angiology, New York
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal