tbuckley/cabot-search huggingface dataset:
New Names
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The frustrations of treating herpes simplex virus infections of the central nervous system
Authors: R. J. Whitley
Journal: JAMA (1988)

Significant advances have been achieved in the therapy for and diagnosis of life-threatening human herpes simplex virus (HSV) infections. Following documentation in both controlled and open studies<sup>1,2</sup>that vidarabine therapy decreased mortality and improved morbidity for patients with biopsy-proved herpes simplex encephalitis, improved outcome was achieved with acyclovir therapy.<sup>3,4</sup>The controlled studies that com See also pp 1051,1054, and 1056. pared acyclovir therapy with vidarabine therapy for herpes simplex encephalitis showed a decrease in mortality to nearly 20% six months after the onset of disease and a return to normal function in approximately 50% of survivors. Therapy for life-threatening neonatal HSV infections, namely, encephalitis and dissemination, has been more complicated. Vidarabine therapy for these forms of neonatal herpes simplex decreases mortality and improves morbidity; however, many patients are left with significant neurological impairment.<sup>5,6</sup>Babies with neonatal HSV infection are currently being followed up to assess school performance,
TO CHAIRMEN AND SECRETARIES OF SECTIONS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment usually unnecessary for 'silent' gallstones
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lye Ingestion
Authors: Jefferson F. Ray
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The CLINICAL NOTE by Sperling and Wheeler, "An Unusual Complication of Lye Ingestion" (228:871, 1974), is marked by an apparent lack of appreciation of current concepts regarding the problem of accidental or suicidal lye ingestion.<sup>1,2</sup>It follows from this that a more aggressive approach to the management of the patient may have been rewarding.<sup>3-6</sup> The problem of lye ingestion has undergone recent dramatic change since liquid lye in the form of household drain cleaners (Drāno [54% NaOH], Liquid Plumr [30.5% NaOH], Plunge [25% NaOH], and Open Up Drain Cleaner [40% KOH]) has become widely available. The ingestion of crystals of lye causes pain, and children commonly stop after a few crystals. Crystals also tend to adhere to the first tissues they reach. Adults bent on suicide commonly swallow crystals with water, thereby diluting the alkali concentration below 3N.<sup>4</sup>Thus, crystalline lye injury tends to
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis
Authors: Sarah M. Greenblatt, Na Man, Pierre-Jacques Hamard, Takashi Asai, Daniel Karl, Concepcion Martinez, Daniel Bilbao, Vasileios Stathias, Anna M. Jermakowicz, Stephanie Duffort, Madhavi Tadi, Ezra Blumenthal, Samantha Newman, Ly Vu, Ye Xu, Fan Liu, Stephan C. Schurer, Michael T. McCabe, Ryan G. Kruger, Mingjiang Xu, Feng-Chun Yang, Daniel G. Tenen, Justin Watts, Francisco Vega, Stephen D. Nimer
Journal: Cancer Cell (2019)
Pharmacokinetic Models for Lipophilic Compounds
Authors: H. B. Matthews, D. B. Tuey, M. W. Anderson
Journal: Environmental Health Perspectives (1977)

In many instances pharmacokinetic modeling offers the best method of interpreting the significance to man of results obtained with laboratory animals but first we must have accurate models for our laboratory animals. A physiological pharmacokinetic model has been used to simulate the disposition of polychlorinated biphenyls (PCBs) in the rat and to extrapolate results obtained with the rat to predict the disposition of PCBs in the mouse. The modeling methods have also been extended to predict the disposition of a polybrominated biphenyl (PBB) in the rat following IV, oral, and multiple oral doses. It is anticipated that with additional experience and work a physiological pharmacokinetic model can be used to predict the disposition of these and other xenobiotics in man.
Genomic Characterization of HIV-Associated Plasmablastic Lymphoma Identifies Pervasive Mutations in the JAK–STAT Pathway
Authors: Zhaoqi Liu, Ioan Filip, Karen Gomez, Dewaldt Engelbrecht, Shabnum Meer, Pooja N. Lalloo, Pareen Patel, Yvonne Perner, Junfei Zhao, Jiguang Wang, Laura Pasqualucci, Raul Rabadan, Pascale Willem
Journal: Blood Cancer Discovery (2020)

Abstract Plasmablastic lymphoma (PBL) is an aggressive B-cell non-Hodgkin lymphoma associated with immunodeficiency in the context of human immunodeficiency virus (HIV) infection or iatrogenic immunosuppression. While a rare disease in general, the incidence is dramatically increased in regions of the world with high HIV prevalence. The molecular pathogenesis of this disease is poorly characterized. Here, we defined the genomic features of PBL in a cohort of 110 patients from South Africa (15 by whole-exome sequencing and 95 by deep targeted sequencing). We identified recurrent mutations in genes of the JAK–STAT signaling pathway, including STAT3 (42%), JAK1 (14%), and SOCS1 (10%), leading to its constitutive activation. Moreover, 24% of cases harbored gain-of-function mutations in RAS family members (NRAS and KRAS). Comparative analysis with other B-cell malignancies uncovered PBL-specific somatic mutations and transcriptional programs. We also found recurrent copy number gains encompassing the CD44 gene (37%), which encodes for a cell surface receptor involved in lymphocyte activation and homing, and was found expressed at high levels in all tested cases, independent of genetic alterations. These findings have implications for the understanding of the pathogenesis of this disease and the development of personalized medicine approaches. Significance: Plasmablastic lymphoma is a poorly studied and extremely aggressive tumor. Here we define the genomic landscape of this lymphoma in HIV-positive individuals from South Africa and identify pervasive mutations in JAK–STAT3 and RAS–MAPK signaling pathways. These data offer a genomic framework for the design of improved treatment strategies targeting these circuits. See related commentary by Küppers, p. 23. This article is highlighted in the In This Issue feature, p. 5
Transient cognitive disorders (delirium, acute confusional states) in the elderly
Authors: Z J Lipowski
Journal: American Journal of Psychiatry (1983)

Transient cognitive disorders (delirium and pseudodelirium) are highly prevalent among the elderly, especially those with brain damage. Delirium is a common feature of physical illness or drug intoxication in elderly patients and requires prompt medical attention. While potentially reversible, delirium may herald death. Pseudodelirium may be induced by psychosocial stress or accompany a functional mental disorder. Transient cognitive disorders must not be confused with dementia, a chronic syndrome. The author discusses clinical features, etiology, pathogenesis, diagnosis, and treatment of delirium and related transient disorders of cognition in the elderly.
Abstract 827: Estimating breast tissue-specific epigenetic age using next-generation methylation sequencing data
Authors: James R. Castle, Nan Lin, Jingpeng Liu, Chi Wang, Yunlong Liu, Chunyan He
Journal: Cancer Research (2019)

Abstract Epigenetic age captures both genetic and environmental influences across time on cellular functions and is an indicator of biological aging. Epigenetic age may deviate from chronological age substantially in individuals. Epigenetic age is also tissue-specific. Emerging evidence suggests that female breast tissue ages faster than other parts of the body according to epigenetic age estimation using the "Horvath Clock" model. The Horvath method is based on the DNA methylation of 353 CpG loci on the outdated Illumina microarray platforms. The increasing availability of next-generation sequencing data calls for method development that uses DNA methylation sequencing data to estimate tissue-specific epigenetic age. We developed a new method to estimate breast tissue-specific epigenetic aging using next-generation methylation sequencing data and assessed the difference between epigenetic and chronological ages, known as epigenetic age acceleration (EAA), in different breast tissue types. The Illumina TruSeq Methyl Capture EPIC Sequencing technology was used to obtain DNA methylation profiles of approximately 3.3 million CpG sites in 111 tumor, 48 matched adjacent normal, and 462 normal breast tissue samples. A total of approximately 1.4 million CpG sites remained after quality control. Following the Horvath approach, we used an elastic net penalized regression model to regress chronological age on CpG sites in normal breast tissue and defined a new set of 247 clock CpGs specific to breast tissue with randomly divided training (n = 370) and testing (n = 92) data sets. We estimated breast tissue-specific epigenetic age and EAA in tumor, adjacent, and normal breast tissue. We found that breast tissue-specific epigenetic age was positively correlated with chronological age (r=0.87; P&amp;lt;2.2X10-16). Neither normal nor adjacent normal breast tissue showed a significant EAA. However, tumor breast tissue had a significant and increased EAA (median = 8.0 years; P=6.9X10-9). While triple-negative breast tumors showed no significant EAA, hormone receptive-positive and Her2-positive breast tumors had a significant and increased EAA (median=9.5 and 13.1 years; P=1X10-5 and 0.02, respectively). Results of this new model were compared to similar results using the Horvath Clock model and were found to be qualitatively consistent. Further research is needed to determine whether epigenetic age acceleration in normal breast tissue is predictive of breast cancer risk and how breast cancer risk factors influence the rate of acceleration. Citation Format: James R. Castle, Nan Lin, Jingpeng Liu, Chi Wang, Yunlong Liu, Chunyan He. Estimating breast tissue-specific epigenetic age using next-generation methylation sequencing data [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 827.
Faecal peritonitis after laxative preparation for barium enema.
Journal: BMJ (1982)

ment and no other respiratory organisms were grown we attempted to identify the organism and carried out sensitivity tests.The organism was resistant to penicillin, ampicillin, cephalexin, fusidic acid, and co-trimoxazole, and was sensitive to tetracycline, lincomycin, and gentamicin.Treatment was changed to lincomycin 500 mg by mouth thrice daily.Before this treatment was started a third specimen of sputum and second specimen of blood were obtained for culture.The sputum specimen again grew the same organism, but blood cultures showed no growth after two weeks' incubation.She became clinically well within five days after the changed treatment.The antibiotic was continued for a total of seven days.Two days later a further specimen of sputum was examined.This was not purulent and did not grow the organism or any known respiratory pathogen.She was discharged and was well at follow-up two weeks later.Bacteriology-Overnight incubation at 37°C produced whitish raised colonies of about 0-5 mm in diameter.Gram-staining showed large nonsporing Gram-positive rods.The organism grew aerobically as well as anaerobically, but slightly better in the presence of carbon dioxide.It was catalase and oxidase negative and non-motile.Similar characteristics were observed in all three cultures.The organism was provisionally named as a Lactobacillus spp and later fully identified by the Central Public Health Laboratory, London, as Lactobacillus casei ss rhamnosus.
Traitement des maladies rhumatismales par la sanocrysine
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of SPARC in normal and fibrotic livers*1
Authors: E FRIZELL
Journal: Hepatology (1995)

SPARC (secreted protein, acidic and rich in cysteine)—also known as osteonectin, BM-40, and 43K glycoprotein—is secreted by endothelial cells and fibroblasts in response to culture shock. SPARC has been found in association with tissues undergoing cell proliferation, migration, and extracellular matrix remodeling. We demonstrate that normal livers from humans, rats, and mice express substantial levels of SPARC messenger RNA (mRNA). Moreover, when compared with control specimens, significantly increased levels of SPARC mRNA were found in fibrotic livers from two animal models of liver disease: murine schistosomiasis and carbon tetrachloride-induced fibrosis in rats. Fibrotic human livers also had markedly increased levels of SPARC mRNA in comparison with normal livers. We also detected an increased production of SPARC protein in the liver of animals treated with carbon tetrachloride. By immunocytochemical analysis, SPARC protein was apparent in freshly isolated Ito cells. Hybridization studies showed Ito cells to be the main source of SPARC mRNA. Extracts from a Kupffer-endothelial cell fraction exhibited traces of SPARC transcript, but expression of SPARC mRNA was absent in extracts from freshly isolated hepatocytes. These studies demonstrate the increased expression of SPARC—a protein that modulates cell shape and disrupts cell—matrix interactions—during the initial stages of hepatic fibrosis.
Erratum for the Research Article: “Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency” by S. S. De Ravin, X. Wu, S. Moir, S. Anaya-O’Brien, N. Kwatemaa, P. Littel, N. Theobald, U. Choi, L. Su, M. Marquesen, D. Hilligoss, J. Lee, C. M. Buckner, K. A. Zarember, G. O’Connor, D. McVicar, D. Kuhns, R. E. Throm, S. Zhou, L. D. Notarangelo, I. C. Hanson, M. J. Cowan, E. Kang, C. Hadigan, M. Meagher, J. T. Gray, B. P. Sorrentino, H. L. Malech
Journal: Science Translational Medicine (2016)
Childhood Lead Poisoning—United States: Report to the Congress by the Agency for Toxic Substances and Disease Registry
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General Practice and Medical Teaching in North America
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familial hyperamylasaemia.
Authors: P M Cuckow, A Y Foo, A Jamal, M D Stringer
Journal: Gut (1997)

A six year old boy underwent extensive investigation for recurrent abdominal pain and was found to have a persistently raised serum amylase. Endoscopic retrograde cholangiopancreatography was normal and macroamylasaemia was excluded. Serum amylase concentrations were found to be raised in other family members spanning three generations, all of whom were asymptomatic. Clearance studies suggested no evidence of a renal tubular defect and serum lipase concentrations were normal. This is the first report of apparently familial hyperamylasaemia and the mode of inheritance is consistent with an autosomal dominant pattern.
Abstract 4404: E-<i>p</i>-Methoxycinnamoyl-α-l-rhamnopyranosyl ester (MCR) increases Nrf2 stability by inhibiting ubiquitination in HaCaT cells
Authors: Jiwon Jeong, Lilik D. Wahyudy, Heejung Yang, Jung-Hwan Kim
Journal: Cancer Research (2019)

Abstract The nuclear factor erythroid-derived 2-related factor 2 (Nrf2) is a key regulator of gene expression during oxidative stress and drug detoxification. Thus, identifying Nrf2 activators to protect from possible cell damage is necessary. In this study, we investigated whether E-p-methoxycinnamoyl-α-l-rhamnopyranosyl ester (MCR), a phenylpropanoid isolated from Scrophularia buergeriana, can activate Nrf2 signaling in human keratinocytes (HaCaT). First, we determined the dose- and time-dependent effects of MCR on the expression and activity of Nrf2. The antioxidant response element-luciferase reporter assay and western blot analysis results showed that MCR markedly induced Nrf2 activity and its protein expression, respectively. Further, MCR increased both the mRNA and protein levels of heme-oxygenase-1, one of the Nrf2 target genes, in the cells. Interestingly, we found that Nrf2 stability was remarkably enhanced by MCR. Furthermore, ubiquitin-dependent proteasomal degradation of Nrf2 was significantly reduced by MCR. Thus, MCR might afford skin protection by enhancing Nrf2 stability or by blocking its proteasomal degradation. Citation Format: Jiwon Jeong, Lilik D. Wahyudy, Heejung Yang, Jung-Hwan Kim. E-p-Methoxycinnamoyl-α-l-rhamnopyranosyl ester (MCR) increases Nrf2 stability by inhibiting ubiquitination in HaCaT cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4404.
The Lymphomas: Current Concepts in Pathogenesis and Management
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article The Lymphomas: Current Concepts in Pathogenesis and Management Get access JNCI: Journal of the National Cancer Institute, Volume 82, Issue 14, 18 July 1990, Page 1229, https://doi.org/10.1093/jnci/82.14.1229 Published: 18 July 1990