tbuckley/cabot-search huggingface dataset:
Antiepileptic Drugs
Authors: Martin J. Brodie, Marc A. Dichter
Journal: New England Journal of Medicine (1996)

At a conservative estimate, 50 million people worldwide have epilepsy. The annual incidence ranges from 20 to 70 cases per 100,0001 and the point prevalence is 0.4 to 0.8 percent.2 The incidence rates are highest in childhood, plateau from the age of 15 to 65 years, and rise again among the elderly. Overall, 5 percent of persons report a seizure at some time in their lives. This figure excludes febrile convulsions, which occur in approximately 5 percent of children. These data suggest that there is a substantial rate of remission, even among persons who never receive treatment with an antiepileptic . . .
Liability crisis or insurance problem?
Authors: R. C. Gillett
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Mr Eugene Pavalon's letter<sup>1</sup>was offered as an attempt to bring some reason to the acrimonious debate over the malpractice issue. Unfortunately, save for the absence of the usual gratuitous criticisms of the medical profession common to statements by the plaintiff's bar, his letter breaks no new ground. Instead, we read an implicit plea for the two professions to unite against a common scapegoat—the insurance industry. Would that the issue were so simple. Those proposing reforms of the legal system are met by arguments such as those of Mr Pavalon, accusing them of attempting "the dismantling of our civil justice system" and the imposition of arbitrary restrictions on the rights of the people. One might even be persuaded that in their zeal to prevent the ravaging of the Constitution, the effect of such proposed changes on the size and number of contingency fees never entered the
Prehospital coronary care. Proposal for a uniform reporting system
Authors: C. A. Polnitsky
Journal: JAMA (1977)

Prehospital coronary care is becoming a common feature of community emergency medical systems. To date, results have been reported in a variety of formats, making meaningful comparison and aggregate analysis impossible. A flexible patient encounter form and data analysis scheme are proposed for universal adoption in future published accounts. (<i>JAMA</i>237:134-137, 1977)
Abstract 11813: The Impact of Surgical Left Atrial Appendage Amputation/Ligation on Stroke Prevention in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
Authors: Daisuke Endo, Tomoko S Kato, Tai Iwamura, Akie Shimada, Kan Kajimoto, Shizuyuki Dohi, Kenji Kuwaki, Taira Yamamoto, Atsushi Amano
Journal: Circulation (2015)

Background: Stroke is a major adverse event in patients developing atrial fibrillation (AF) after cardiac surgery. Left atrial appendage (LAA) closure using devices is expected to prevent stroke and enable patients to be warfarin free; however, problems such as procedure-related adverse events and possible residual flow remain unsolved. Concomitant “surgical” LAA amputation/ligation (LAA-A/L) during off-pump coronary artery bypass grafting (OPCAB) is actively performed in our institution. Methods: This is a prospective observational study of 578 consecutive patients (mean age 69 ± 9.8 years, Male 82%) undergoing OPCAB with or without concomitant LAA-A/L from 2011 to 2014. The safety and efficacy of the concomitant procedure, performed on 193 (33%) patients, on preventing early (&lt;30 days) and late postoperative stroke were examined. Results: LAA was amputated in 154 patients (80%), and ligated in 39 (20%). Between patients with and without LAA-A/L, no difference was seen in the preoperative characteristics including CHADS2 and CHA2DS2-VASc scores, and no significant differences in their operative time, requirement of blood transfusion, length of ICU and total hospital stay were noted. The incidence of postoperative AF was not different (33% vs. 28%, p=0.18), and early and late stroke incidences were not significantly different between the groups (1.0% vs. 0.8%, p=0.75, 2.2% vs. 2.8% p=0.67, respectively). However, in patients without LAA-A/L, both early and late stroke occurred more frequently in those developing AF (2.8% vs. 0%, p=0.005, 6.2% vs. 1.5%; p=0.017, respectively), while stroke incidence in patients receiving LAA-A/L, was not significantly different between those with and without postoperative AF (0.8% vs. 1.6%, p=0.61, 1.6% vs. 2.5%; p=0.69, respectively). Multivariate logistic regression showed postoperative AF without LAA-A/L as the only independent positive predictor of early (OR: 6.8; 95% CI: 1.11 to 52.60; p=0.04) and late (OR: 3.7; 95% CI: 1.18 to 10.94; p=0.03) stroke. Conclusions: Concomitant LAA-A/L with OPCAB is safe and effective for stroke prevention in patients developing postoperative AF. This preventative procedure seems beneficial, since AF is the most common arrhythmia associated with the risk of stroke.
From the author
Authors: R. Bals
Journal: European Respiratory Journal (2005)

LPS on two occasions separated by o3 weeks.However, none of these studies had observed tolerance towards subsequent LPS challenge(s) in their healthy human subjects at doses of LPS described that were higher than ours.It is possible that tolerance in healthy nonatopic human subjects only occurs in exposure to lower doses of inhaled endoxin.In fact, existing literature indicates that exposure of 30-40 mg inhaled LPS is probably the clinical threshold to induce symptoms and lung function changes for healthy subjects [4].
ELECTRON MICROSCOPE
Authors: A. E. Taft
Journal: JAMA (1941)

<h3>To the Editor:—</h3> May I add a comment to the interesting and important question of examination of tissue with the electron microscope? It is important always to have in mind that any change in the water content away from the normal of cells or tissues results in a change in their internal structure. In the study reported by Seymour and Benmosche (The Journal, May 31, p. 2489) the cells examined had been in distilled water, a medium not iso-osmotic with the normal fluid surrounding of any body cells. Immersion in distilled water would result in an imbibition swelling, which would alter the physical cell structure considerably from its living condition. This is equally true of most technical methods, whether they involve drying, boiling or freezing or any means that alters normal water relations. Until some method can be devised for examining cells or tissues in an accurately iso-osmotic medium, interpretation
MEDICAL INTEREST IN TAX REVISION
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Free-Radical Chemistry of Sulfite
Authors: P. Neta, Robert E. Huie
Journal: Environmental Health Perspectives (1985)

The free-radical chemistry of sulfite oxidation is reviewed. Chemical transformations of organic and biological molecules induced by sulfite oxidation are summarized. The kinetics of the free-radical oxidations of sulfite are discussed, as are the kinetics of the reactions of the sulfite-derived radicals SO3 and the peroxy derivative SO5 with organic compounds.
Logician
Authors: Max Burger
Journal: JAMA (1997)

For many, the prospect of buying a computerized record system is daunting. Beyond upgrading hardware and making sure that the billing system is compatible, it will simply change the way you work. Ancillary staff must be trained and have as much buy-in to the process as the practitioners. Windows-based programs certainly will help, but with such a program, standard procedures will have to be reengineered to adapt to the wider scope of the new technology. Appointments will be scheduled on screen. Patients, with their health insurance identified, will be identified by a photo. Messages will be taken on-line and sent to a screen for a response. Lab reports will be downloaded and immediately available in the chart. Prescriptions, after they have been checked for allergies, interactions, formulary status, and cost, will be faxed or electronically transmitted to a pharmacy. The clinical encounter will be instantly printed and accessible to anyone
Granulocytic myeloid-derived suppressor cells contribute to HBV-related acute-on-chronic liver failure infection and mortality by inducing T cell exhaustion
Authors: Xueping Yu, Feifei Yang, Richeng Mao, Songhua Yuan, Yu Yang, Haoxiang Zhu, Chao Qiu, Zhijun Su, Jiming Zhang
Journal: Journal of Hepatology (2020)
Digest
Authors: Emad El-Omar, Severine Vermeire, Alexander Gerbes
Journal: Gut (2010)

Me ´ne ´trier's disease: what you need to knowMénétrier's disease (MD) is a rare form of acquired gastropathy characterised by giant rugal folds in the gastric body, foveolar hyperplasia and markedly decreased or absent oxyntic glands.The later explains why most of these patients have hypochlorhydria.The pathogenesis of MD is related to increased epidermal growth factor receptor (EGFR) signalling in the stomach.It is fair to say that most gastroenterologists know little about the condition!Rich et al evaluated 48 individuals over a 10-year period for possible enrolment into a clinical trial utilising Cetuximab, a monoclonal antibody to the EGFR.In this interesting paper, the authors share their extensive experience with this rare condition.They describe the clinical and histological features of MD, characterise the conditions that mimic MD and propose a diagnostic algorithm for clinicians and pathologists when MD is suspected.It is certainly worth a read by all doctors.See page 1617.
LIABILITY OF A PHYSICIAN FOR SELLING INTOXICATING LIQUORS IN IOWA.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply:
Authors: Olle Ringdén
Journal: Journal of Clinical Oncology (2004)

factors should be confined to patients experiencing delayed engraftment.Is there a place for a controlled study of the use of myeloid growth factors after allogeneic BSCT, performed optimally with methotrexate-containing graft-versus-host disease prophylaxis, 2,11 to demonstrate their safety (or, unhappily, the lack of it)?With the number of vital issues to be addressed in the field of hematopoietic allografts, I do not believe this question is sufficiently high priority.
Will surgery on the cornea render spectacles obsolete?
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Procainamide hydrochloride and lupus erythematosus
Authors: R. Paine
Journal: JAMA (1965)

Four patients developed a lupus erythematosus (LE)-like syndrome while taking procainamide hydrochloride. All four presented with acute pain in the joints; three with fever; two with pulmonary infiltration; and three with chest pain. Prompt subsidence of symptoms and signs followed cessation of procainamide administration in three patients, while joint symptoms and LE cells persisted until dexamethasone was given to another. Partial subsidence of symptoms and signs, despite continued administration, was observed in one patient. The importance of long-term administration in the genesis of this reaction to procainamide is noted.
Plasma protein glycomics combined with circulating fragments of cytokeratin-18 are reliable biomarkers to diagnose alcoholic hepatitis
Authors: Verhelst Xavier, Anja Geerts, Leander Meuris, Helena Degroote, Marion Tanguy, Hortense Davy, Tazime Issoufaly, François Durand, Nico Callewaert, Hans Van Vlierberghe, Pierre-Emmanuel Rautou
Journal: Journal of Hepatology (2020)
The protective efficacy of immune serum globulin in hepatitis A: a statistical approach
Authors: P. J. Landrigan
Journal: JAMA (1973)

In a community outbreak of hepatitis A (person-to-person transmission) the efficacy of immune serum globulin prophylaxis among patients'family members was between 87% and 98%. Immune serum globulin efficacy was determined by means of a formula used previously to measure live-virus vaccine efficacy in epidemics.
A Phase 1 Trial of Ruxolitinib, Lenalidomide and Methylprednisolone for Patients with Relapsed/Refractory Multiple Myeloma (MM)
Authors: James R. Berenson, Jennifer To, Tanya M. Spektor, Daisy Martinez, Armando J. Sanchez, Carley Turner, Regina Swift, Benjamin Eades, Gary Schwartz, Shahrooz Eshaghian, Laura V. Stampleman, Robert A. Moss, Youram Nassir, Ravindranath Patel, Alberto Bessudo, Daniel Greenwald, Ralph V. Boccia, Stephen Lim, Robert Vescio
Journal: Blood (2019)
Acta Path et Microbiol Scand, Copenhagen
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Financial toxicity, symptom burden, illness perceptions, and communication confidence in cancer clinical trial participants.
Authors: Subha Perni, Emily Gorton, Elyse R Park, Bruce Allan Chabner, Beverly Moy, Ryan David Nipp
Journal: Journal of Clinical Oncology (2021)

6526 Background: Cancer clinical trial (CCT) participants are at high risk for experiencing adverse effects from financial toxicity, yet this remains understudied in the CCT population. We sought to describe associations among patient-reported financial toxicity (financial burden [FB] and trial cost concerns), physical and psychological symptoms, illness perceptions, and communication confidence in CCT participants. Methods: From 7/2015-7/2017, we prospectively enrolled CCT participants who expressed interest in financial assistance and a group of patients matched by age, sex, cancer type, specific trial, and trial phase. We assessed FB (burdened by costs of cancer care), trial cost concerns (worried about affording medical costs of a CCT), physical (Edmonton Symptom Assessment Scale [ESAS]) and psychological (Patient Health Questionnaire-4 [PHQ-4]) symptoms, illness perceptions (Brief Illness Perception Questionnaire [BIPQ]), and communication confidence (Perceived Efficacy in Patient-Physician Interactions [PEPPI]). We used regression models to explore sociodemographic associations with FB and trial cost concerns, and to examine associations of FB and trial cost concerns with patients’ symptom burden, illness perceptions, and communication confidence, adjusting for age, sex, race, performance status, marital status, and metastatic status. Results: Of 198 patients enrolled, 112 (56.6%) reported FB and 82 (41.4%) had trial cost concerns. Patients with FB were younger (OR 0.96, 95% CI 0.94-0.98) and had lower incomes ( &lt; $100,000, OR 4.61, 95% CI 2.35-9.01). Patients reporting trial cost concerns also had lower incomes ( &lt; $100,000, OR 2.78, 95% CI 1.45-5.29). On adjusted analyses, patients with FB had higher ESAS total (OR 1.03, 95% CI 1.02-1.05), ESAS physical (OR 1.04, 95% CI 1.02-1.07), PHQ-4 depression (OR 1.54, 95% CI 1.22-1.94), and PHQ-4 anxiety (OR 1.30, 95% CI 1.08-1.55) scores, as well as more negative illness perceptions (OR 1.04, 95% CI 1.01-1.07), but no significant difference in communication confidence (OR 0.98, 95% CI 0.93-1.05). Patients reporting trial cost concerns had higher ESAS total (OR 1.03, 95% CI 1.01-1.05), ESAS physical (OR 1.04, 95% CI 1.01-1.06), PHQ-4 depression (OR 1.35, 95% CI 1.10-1.65), and PHQ-4 anxiety (OR 1.27, 95% CI 1.07-1.51) scores, as well as more negative illness perceptions (OR 1.06, 95% CI 1.03-1.10), and lower communication confidence (OR 0.93, 95% CI 0.87-0.99). Conclusions: In this study of CCT participants, younger patients with lower incomes were most vulnerable to financial toxicity. Financial toxicity was associated with greater symptom burden, more negative illness perceptions, and lower communication confidence, which underscores the importance of addressing these issues when seeking to alleviate the adverse effects of financial toxicity in CCT participants.
Comparative Metabolism of Chloroacetamide Herbicides and Selected Metabolites in Human and Rat Liver Microsomes
Authors: Scott Coleman, Russell Linderman, Ernest Hodgson, Randy L. Rose
Journal: Environmental Health Perspectives (2000)

Acetochlor [2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methyl-phenyl)-acetamide], alachlor [N-(methoxymethyl)-2-chloro-N-(2,6-diethyl-phenyl)acetamide], butachlor [N-(butoxymethyl)-2chloro-N-(2,6-diethyl-phenyl)acetamide], and metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl) acetamide] are pre-emergent herbicides used in the production of agricultural crops.These herbicides are carcinogenic in rats: acetochlor and alachlor cause tumors in the nasal turbinates, butachlor causes stomach tumors, and metolachlor causes liver tumors.It has been suggested that the carcinogenicity of these compounds involves a complex metabolic activation pathway leading to a DNA-reactive dialkylbenzoquinone imine.Important intermediates in this pathway are 2-chloro-N-(2,6-diethylphenyl)acetamide (CDEPA) produced from alachlor and butachlor and 2-chloro-N-(2-methyl-6-ethylphenyl)acetamide (CMEPA) produced from acetochlor and metolachlor.Subsequent metabolism of CDEPA and CMEPA produces 2,6-diethylaniline (DEA) and 2-methyl-6-ethylaniline (MEA), which are bioactivated through para-hydroxylationand subsequent oxidation to the proposed carcinogenic product dialkylbenzoquinone imine.The current study extends our earlier studies with alachlor and demonstrates that rat liver microsomes metabolize acetochlor and metolachlor to CMEPA (0.065 nmol/min/mg and 0.0133 nmol/min/mg, respectively), whereas human liver microsomes can metabolize only acetochlor to CMEPA (0.023 nmol/min/mg).Butachlor is metabolized to CDEPA to a much greater extent by rat liver microsomes (0.045 nmol/min/mg) than by human liver microsomes (< 0.001 nmol/min/mg).We have determined that both rat and human livers metabolize both CMEPA to MEA (0.308 nmol/min/mg and 0.541 nmol/min/mg, respectively) and CDEPA to DEA (0.350 nmol/min/mg and 0.841 nmol/min/mg, respectively).We have shown that both rat and human liver microsomes metabolize MEA (0.035 nmol/min/mg and 0.069 nmol/min/mg, respectively) and DEA (0.041 nmol/min/mg and 0.040 nmol/min/mg, respectively).We have also shown that the cytochrome P450 isoforms responsible for human metabolism of acetochlor, butachlor, and metolachlor are CYP3A4 and CYP2B6.
The effect of panel-reactive antibody titers on liver transplantation T. H. Renard, M. F. Levy, C. Eisenstein, D. Distant, L. Backman, R. Goldstein, B. Husberg, T. A. Gonwa, and G. B. Klintmalm. Baylor Univ Med Center, 3500 Gaston Ave, Dallas, Texas 75246
Journal: Hepatology (1993)
Panelists
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal