tbuckley/cabot-search huggingface dataset:
In Reply
Authors: Nahoko Kaniwa, Emiko Sugiyama, Su-Ryang Kim, Yoshiro Saito, Jun-ichi Sawada, Junji Furuse, Hiroshi Ishii, Teruhiko Yoshida, Hideki Ueno, Takuji Okusaka, Nagahiro Saijo
Journal: Journal of Clinical Oncology (2007)
Presidential plenary II
Journal: Hepatology (2003)

An empirical kinetic modeling approach was used in order to simulate ozone, formaldehyde and acetaldehyde concentrations for an urban downtown area with high vehicular traffic. A base case was designed using experimental data for December 1999 in Presidente Vargas Avenue, Rio de Janeiro, Brazil. The simulated ozone peak was obtained at 3:15 PM (23.00 ppb) in good agreement with experimental results. Calculated acetaldehyde and formaldehyde concentrations peaked at 21–24 and 14–17 ppb, respectively, between 11:00 AM and 13:00 PM, depending on the effective solar flux. Tagged species were used to discriminate between primary and secondary compounds and to follow the reaction paths of individual species. Computational results show that the primary contribution to acetaldehyde and formaldehyde concentrations is higher in the early morning and reaches a maximum, which approximately coincides with the peak automobile traffic. The secondary contribution increases during the morning and reaches a maximum in the early afternoon. As a consequence, total acetaldehyde and formaldehyde levels peak after the primary pollutants’ maximum, obtained in the early morning, and before the secondary pollutants’ maximum as previously noted in experimental determinations. The simulations also confirm the experimental evidence that the high acetaldehyde/formaldehyde ratios are due to the use of alcohol-based fuels.
FASEB Summer Research Conference: Dynamic Structure of the Nuclear Hormone Receptors
Journal: Endocrine Reviews (2009)

This conference will focus on our current knowledge of mechanisms regulating nuclear receptor function.Topics to be discussed include nuclear receptor structure function; modulation of nuclear receptor structure by ligand, DNA, and proteins; role of unfolded domains and coregulatory proteins on nuclear receptor function; nuclear receptors and chromatin; dynamic movement of nuclear hormone receptors; and nuclear receptor-mediated gene expression.Poster presentations will be scheduled to include additional information on related topics.
Abstract 10397: Higher Waist Circumference is the Start of Cardiovascular Structural and Functional Changes in Childhood Obesity
Authors: Kenji Harada, Yukiko Harada, Manatomo Toyono
Journal: Circulation (2015)

Background: Higher waist circumference (WC) is associated with cardiovascular disease, however, little is known about the association between WC and cardiovascular functional change in children. The purpose of this study is to examine the relationships between numbers of cardiovascular risk factors and left ventricular (LV) geometry and function in children. Methods: Echocardiography was performed in 311 children aged 7 to 13 years. Left atrial (LA) diameter, LV end-diastolic volume, ejection fraction, mass, mass-to-volume ratio, and carotid artery intima media-thickness (IMT) were measured. Transmitral peak flow velocities during early and late diastole and mitral annular myocardial velocities during early (Em) and late diastole (Am) were measured. LA systolic force and aortic stiffness were calculated. Lipids, uric acid, fasting glucose, insulin, high sensitive CRP, and homeostasis model assessment for insulin resistance (HOMA-IR) were also assessed. Subjects were divided into 4 groups: A group, WC within normal range; B group, increased WC; C group, increased WC plus any one of the following individual factors of hypertension, dyslipidemia (low high-density lipoprotein-cholesterol and/or high triglyceride), and raised fasting glucose; D group, metabolic syndrome. Results: Compared with the A group, LA diameter, mass/volume ratio, HOMA-IR, and uric acid were greater in the B group (p&lt;0.05 for all). With increasing number of metabolic syndrome disorders (C and D groups), dyslipidemia, increased Hs-CRP, decreased Em/Am, enhanced LA systolic force, increased IMT, and aortic stiffening were observed (Table). Conclusions: Higher WC is associated with insulin resistance, hyperuricemia, and concentric LV hypertrophy. Cardiovascular structural and functional changes become apparent with increasing number of metabolic syndrome disorders. Our findings suggest that primary prevention programs should be initiated in children with increased WC.
Drug-Resistant TB
Authors: Joan Stephenson
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum transferrin receptor
Authors: Barry S. Skikne
Journal: American Journal of Hematology (2008)

Abstract Transferrin receptors (TfRs) are the conventional pathway by which cells acquire iron for physiological requirements. Under iron‐deficient conditions there is an increased concentration of surface TfR, especially on bone marrow erythroid precursors, as a mechanism to sequester needed iron. TfRs are also present in the circulation, and the circulating serum TfR (sTfR) level reflects total body TfR concentration. Under normal conditions erythroid precursors are the main source of sTfR. Disorders of the bone marrow with reduced erythroid precursors are associated with low sTfR levels. The sTfR concentration begins to rise early in iron deficiency with the onset of iron‐deficient erythropoiesis, and continues to rise as iron‐deficient erythropoiesis progressively worsens, prior to the development of anemia. The sTfR level does not increase in anemia of chronic inflammation, but is increased when anemia of chronic inflammation is combined with iron deficiency. The sTfR level is also increased in patients with expanded erythropoiesis, including hemolytic anemias, myelodysplastic syndromes, and use of erythropoietic stimulating agents. The ratio of sTfR/ferritin can be used to quantify the entire spectrum of iron status from positive iron stores through negative iron balance, and is particularly useful in evaluating iron status in population studies. The sTfR/log ferritin ratio is valuable for distinguishing anemia of chronic inflammation from iron deficiency anemia, whether the latter occurs alone or in combination with anemia of chronic inflammation. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
In This Issue
Journal: Journal of Clinical Investigation (2009)

α-Synuclein phosphorylation: a balancing act in Parkinson diseaseBoth genetic and pathologic data indicate a role for the neuronal protein α-synuclein in the pathogenesis of Parkinson disease.Previous studies have indicated that phosphorylation of α-synuclein Ser129 is a key event in α-synuclein-mediated neurotoxicity.Chen and colleagues have identified a counterbalancing role in neuroprotection for phosphorylation of α-synuclein Tyr125 (3257-3265).Specifically, in Drosophila transgenic for human α-synuclein, phosphorylation of human α-synuclein Tyr125 was detected and shown to protect from α-synuclein neurotoxicity.The two phosphorylated amino acids were shown to have opposing roles when the authors observed that Tyr125 phosphorylation decreased levels of toxic soluble α-synuclein oligomers in the Drosophila brain, whereas Ser129 phosphorylation increased them.Tyr125 phosphorylation was found to decrease as both humans and Drosophila aged and was reduced in cortical tissue from patients with synucleinopathy dementia with Lewy bodies, a disease related to Parkinson disease.Therefore, changes in the balance between Ser129 and Tyr125 phosphorylation - which promote neurotoxicity and neuroprotection, respectively - might cause α-synuclein neurotoxicity in Parkinson disease and related disorders.
The Empire Rheumatism Council: Progress Report
Journal: Annals of the Rheumatic Diseases (1941)

DEVELOPMENTS during the past half-year amply justified the courageous decision of the Empire Rheumatism Council to carry on with its work despite the outbreak of war.There has been very encouraging progress.Particularly gratifying has been the manifestation of warm American sympathy with our work.The following are extracts from letters received:Dr. Homer F. Swift
The Clinical Convention
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IRB Reform
Authors: Eve E. Slater
Journal: New England Journal of Medicine (2002)

We have come a long way since the 1960s, when ethical questions about research involving human subjects brought the issue to national attention. Nonetheless, the current system for safeguarding people who volunteer for clinical trials is under stress because of the unprecedented growth in clinical research.13 Since 1995, federal funding for research has more than doubled. From 1997 to 2000, the estimated number of participants in federally funded research increased from 7 million to almost 12 million4 (and Seto B: personal communication). Privately sponsored clinical research has grown at a similar pace.5 To paraphrase Snyderman and Holmes, as our . . .
In This Issue
Journal: Journal of Clinical Investigation (2009)

Local Ca 2+ regulation by PMCA4b in cardiomyocytesCardiomyocyte contraction requires extreme changes in cytoplasmic Ca 2+ concentration.In this context, it is difficult to understand how Ca 2+ -dependent intracellular signaling, which is linked to the initiation of cardiac hypertrophy, is regulated.Plasma membrane Ca 2+ -ATPase (PMCA) proteins are one family of proteins implicated in controlling Ca 2+ -dependent signaling at select subsarcolemmal microdomains.In this issue (976-985), Wu and colleagues have shown in mice that PMCA4b reduces local Ca 2+ levels, such that calcineurin-regulated nuclear factor of activated T cells (NFAT) signals involved in initiating cardiac hypertrophy are reduced.Analysis of mice, engineered such that PMCA4b expression was induced specifically in cardiomyocytes, demonstrated that the global Ca 2+ cycling that controls cardiomyocyte contraction occurred normally, as did exercise-induced hypertrophy.By contrast, the mice showed reduced pathologic cardiac hypertrophy in two models of the disease (including transverse aortic constriction [TAC], a model of high blood pressure-induced cardiac hypertrophy).Consistent with this, mice lacking PMCA4b exhibited increased cardiac hypertrophy following TAC.Mechanistically, TAC increased the amount of PMCA4b interacting with calcineurin and reduced calcineurin/NFAT activity.The authors therefore conclude that PMCA4b functions in cardiomyocytes to reduce Ca 2+ levels at subsarcolemmal microdomains controlling calcineurin/NFAT signaling.
A Fact Database for Toxicological Data at the National Institute of Hygienic Sciences, Japan
Authors: Makoto Hayashi, Masahiro Nakadate, Takaharu Osada, Tamotsu Ishibe, Satoru Tanaka, Akihiko Maekawa, Toshio Sofuni, Yasuko Nakata, Naoko Kanoh, Shigeko Hashiba, Yusuke Takenaka, Motoi Ishidate
Journal: Environmental Health Perspectives (1991)
Dietary Tannins And Salivary Proline-Rich Proteins: Interactions, Induction, And Defense Mechanisms
Authors: H Mehansho
Journal: Annual Review of Nutrition (1987)

The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved ...Read More
Abstract 1708: An integrated framework for genome analysis reveals numerous previously unrecognizable structural variants in leukemia patients’ samples
Authors: James R. Broach, Jie Xu, Emily Schleicher, Christopher Pool, Max Hennessy, Kathryn Sheldon, Charyguly Annageldiyev, Arati Sharma, Yuanyuan Chang, Alex Hastie, Barbara Miller, David Goldenberg, David Claxton, George-Lucian Moldovan, Feng Yue
Journal: Cancer Research (2019)

Abstract We have applied a combination of whole genome sequencing and optical genomic mapping to a number of adult and pediatric leukemia samples, which revealed in each of these samples a large number of structural variants not recognizable by current standard genomic analyses. We developed computational methods to determine which of those variants likely arose as somatic mutations. The method identified 97% of the translocations previously reported by karyotype analysis of these samples and revealed an additional fivefold more such somatic rearrangements. The method identified on average tens of previously unrecognizable inversions and duplications and hundreds of previously unrecognizable insertions and deletions. These structural variants affected a number of leukemia associated genes as well as cancer driver genes not previously associated with leukemia and genes not previously associated with cancer. A number of variants only affected intergenic regions but caused cis-acting alterations in expression of neighboring genes. Analysis of TCGA data indicates that several of the recurrently mutated genes significantly affect survival of AML patients. Our results suggest that current genomic analysis methods fail to identify a majority of structural variants in leukemia samples and this lacunae may hamper diagnostic and prognostic efforts. Note: This abstract was not presented at the meeting. Citation Format: James R. Broach, Jie Xu, Emily Schleicher, Christopher Pool, Max Hennessy, Kathryn Sheldon, Charyguly Annageldiyev, Arati Sharma, Yuanyuan Chang, Alex Hastie, Barbara Miller, David Goldenberg, David Claxton, George-Lucian Moldovan, Feng Yue. An integrated framework for genome analysis reveals numerous previously unrecognizable structural variants in leukemia patients’ samples [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1708.
Code of Ethics.
Authors: H. J. B. Wright
Journal: JAMA (1893)

<h3>To the Editor of The Journal of the American Medical Association.</h3><h3>Dear Sir:</h3> —The " Code" question it appears is not yet settled. I have read with care everything that I have seen in print on both sides of the question and I must confess that I have not seen a single convincing argument that the Code should be abolished or materially changed or amended. There have been many harsh and positive assertions that the Code is an awful document, that its language is bad, that it is old and that it does great injustice to somebody, and many other similar expressions, but such declarations are not arguments, and what these fellows want I do not believe any one can tell; one will assert that the Code is old and therefore it should be abolished and another will assert that the Code never has been enforced and never can be, and
Children With Elevated Blood Lead Levels Attributed to Home Renovation and Remodeling Activities—New York, 1993-1994
Journal: JAMA (1997)

Renovation and remodeling activities that disturb lead-based paint can create substantial amounts of lead dust in the home; such dust can then be inhaled or ingested by children. In January 1995, the New York State Department of Health (NYSDOH) assessed lead exposure among children resulting from home renovation and remodeling during 1993-1994. This report summarizes findings of the study, which identified 320 children in New York state (excluding New York City) with blood lead levels (BLLs) > or = 20 micrograms/dL that were considered to be attributable to residential renovation and remodeling.
Infants of mothers with megaloblastic anemia due to folate deficiency
Authors: J. A. Pritchard
Journal: JAMA (1970)

To try to ascertain the effects of severe maternal folate deficiency on the products of conception, we investigated the fate of 86 infants of women with folate deficiency so severe as to cause overt megaloblastic anemia. Perinatal mortality, fetal malformation, birthweight, prematurity, and neonatal hemoglobin concentration were very similar to those of the general obstetric population cared for at the same institution. Therefore, it appears very unlikely that intensive public health measures focused on providing folicacid supplementation to eradicate all suspicions of maternal folate deficiency would have a dramatic effect on reducing pregnancy wasteage.
The Association between Infection with Hepatitis C Virus and Diabetes
Journal: Annals of Internal Medicine (2000)

Summaries for Patients17 October 2000The Association between Infection with Hepatitis C Virus and DiabetesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-8-200010170-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Infection with hepatitis C virus (HCV) can lead to liver problems. Chronic HCV infection has also been associated with illnesses not related to the liver. For example, some small studies suggest that diabetes is more common in people with HCV infection than in persons without it. Diabetes affects the body's ability to produce or respond to insulin, a hormone that regulates how the body uses carbohydrate, protein, and fat. There are two types of diabetes. Type 1 diabetes begins during childhood or young adulthood. People with type 1 ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Prevalence of Type 2 Diabetes Mellitus among Persons with Hepatitis C Virus Infection in the United States.” It is in the 17 October 2000 issue of Annals of Internal Medicine (volume 133, pages 592-599). The authors are SH Mehta, FL Brancati, MS Sulkowski, SA Strathdee, M Szklo, and DL Thomas.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPrevalence of Type 2 Diabetes Mellitus among Persons with Hepatitis C Virus Infection in the United States Shruti H. Mehta , Frederick L. Brancati , Mark S. Sulkowski , Steffanie A. Strathdee , Moyses Szklo , and David L. Thomas Metrics 17 October 2000Volume 133, Issue 8Page: I-40KeywordsAdipose tissueBlood sugarHealth surveysHematologic testsHepatitis C virusInfectious hepatitisInsulinLiverType 1 diabetesType 2 diabetes ePublished: 17 October 2000 Issue Published: 17 October 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
FRENCH METHODS TO INCREASE BIRTH-RATE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PHARMACOPEIA AND PHYSICIANS.CHAPTER I.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal