tbuckley/cabot-search huggingface dataset:
THE NEWSPAPERS' VERSION OF OSLER'S FAREWELL.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Sentences in Abstract
Journal: JAMA Psychiatry (2015)

John C. Fortney, PhD; Jeffrey M. Pyne, MD; Timothy A. Kimbrell, MD; Teresa J. Hudson, PharmD; Dean E. Robinson, MD; Ronald Schneider, MD; William M. Moore, PhD; Paul J. Custer, PhD; Kathleen M. Grubbs, PhD; Paula P. Schnurr, PhD
New high-resolution ultrasound evaluation of diseases of the thyroid gland. A review article
Authors: C. Cole-Beuglet
Journal: JAMA (1983)

NEW high-resolution ultrasound equipment provides detailed imaging of the normal and abnormal thyroid gland. When a thyroid mass is palpated or imaged as a "cold" area on a radionuclide scan, ultrasound can be used to characterize the area as fluidfilled, solid, or complex, a combination of the two. Detection of a multinodular gland when only one nodule is clinically evident or imaged on radionuclide scan favors the diagnosis of benign disease. This review presents a description of new equipment and scan techniques and describes the appearance of the normal and abnormal thyroid gland with ultrasound. <h3>Ultrasound Equipment</h3> The recent development of high-frequency transducers (7.5 and 10 MHz), focused within a few centimeters of the crystal face, allows for detailed ultrasonic visualization of the superficially located thyroid gland. New dedicated "small parts" B-scanners contain these high-frequency transducers placed within self-contained water baths. This eliminates the strong artifact skin-surface echoes that result
Anaphylactoid reactions associated with parenteral cyclosporine use: Possible role of Cremophor ELHowrie DL, Ptachcinski RJ, Griffith BP, Hardesty RJ, Rosenthal JT, Burckart GJ, Venkataramanan R: Drug Intell Clin Pharm 19:425, 1985
Authors: None JS
Journal: Journal of Allergy and Clinical Immunology (1986)
Diminishing Racial Disparities in Early-Onset Neonatal Group B Streptococcal Disease—United States, 2000-2003
Journal: JAMA (2004)

Increased use of intrapartum antibiotics to prevent perinatal group B streptococcal (GBS) disease during the 1990s led to substantial declines in the incidence of GBS disease in newborns. Despite this success, at the end of the 1990s, early-onset GBS disease (in infants aged <7 days) continued to be a leading infectious cause of neonatal mortality in the United States, and black infants remained at higher risk than white infants. In 2002, CDC and the American College of Obstetricians and Gynecologists (ACOG) revised guidelines for prevention of early-onset GBS disease to recommend late prenatal screening of all pregnant women and intrapartum antibiotic prophylaxis (IAP) for GBS carriers. These guidelines were expected to result in further declines in early-onset disease. This report updates early-onset incidence trends since 1999 analyzed by using population-based, multistate data from the Active Bacterial Core surveillance (ABCs)/Emerging Infections Program Network. The results of the analysis indicated that 1) after a plateau in early-onset disease incidence during 1999-2002, rates declined 34% in 2003 and 2) although racial disparities in incidence persist, rates for blacks now approach the 2010 national health objective of 0.5 cases per 1,000 live births. Continued implementation of screening and prophylaxis guidelines by clinicians and public health practitioners should lead to further declines in racial disparities.
Correction: Boxing and the brain
Journal: BMJ (1989)

surgeons in the future, especially if they are confronted by a need to increase their pay bed revenues.Although the nature of the private sector has changed little between 1981 and 1986, the noticeable expansion in activity, particularly in the Thames regions, once again raises the question of the NHS procedure for resource allocation.Recently proposed revisions to this procedure would, broadly speaking, redirect funding back towards some of the Thames regions.It is difficult to see how the Thames regions can be relatively underresourced, as is implied by this redistribution, when they have the average number of acute NHS beds for the English regions and one quarter of their elective surgical treatments are provided outside the NHS.There is presumably some upper limit on the proportion of elective surgical treatments that can be provided privately before it is felt that some adjustment to the resource allocation formulas should be made.The main problem in including the private sector in the resource allocation calculations would be the practical difficulty of distinguishing between that part of the private sector activity which would otherwise have to be carried out in the NHS and activity which is merely additional to that in the NHS.This issue will become particularly important if the current government review seeks greatly to expand the role of the private sector and, in some manner, to integrate its activity with that of the NHS.
"Nil by mouth" after gastrointestinal surgery may be harmful
Journal: BMJ (2001)

Nil by mouth" after gastrointestinal surgery may be harmfulEarly feeding after gastrointestinal surgery reduces the risk of infections and shortens length of stay in hospital.Lewis and colleagues (p 773) systematically reviewed the evidence from randomised controlled trials that compared early feeding with management by "nil by mouth" after elective gastrointestinal surgery.The authors argue that keeping patients nil by mouth may do more harm than good and that a large trial is required to confirm or refute the benefits of early feeding that were seen in small trials.
Klinische Pathophysiologie
Authors: Frederic T. Jung
Journal: JAMA (1970)

It is difficult to convey a sense of the magnificence of this work. Its attractive external appearance and its physical bulk—997 pages of two-column text plus 35 pages of a detailed four-column index—are matched by the high quality of its contents. The staggering quantity of physiological research now being published defies assimilation by a single person, and this fact is manifested in some existing textbooks in which allusions take the place of precise explanations and the reader finds presentations of theory instead of answers to practical questions. In the present book, 67 contributors have concentrated on the clinical application of their specialized knowledge. Particularly good examples of the result are seen in the concluding chapters on the physiological effects of poisons, of heat and cold, of ionizing radiations, and of electric currents, subjects that are too often slighted or altogether ignored. The sequence of topics is genetics, metabolism, internal secretions,
Neurology
Authors: R. J. Joynt
Journal: JAMA (1993)

The changes in the practice of neurology have been dramatic in the past decade. Physicians graduating over 20 years ago recollect a specialty with great intellectual challenges but with few therapeutic opportunities. Now therapy is advancing in many areas, and major trials are providing information about treatment efficacy, failures, side effects, and complications. Therapies are based on the fundamental knowledge of the disease processes learned through the use of new research techniques. There here is now some promise of altering the course of multiple sclerosis by vaccine therapy, intravenous immunoglobulin, or use of interferon. The vaccine is made up of immunogenic fragments of myelin basic protein. Experimental studies indicate that this vaccination will largely prevent the induction of allergic encephalomyelitis, a model for multiple sclerosis, in laboratory animals.<sup>1</sup>Intravenous immunoglobulin has been used for a number of autoimmune disorders, including chronic inflammatory demyelinating neuropathy, myasthenia gravis, and inflammatory myopathies.
Antibody-Drug Conjugates Targeted to CD79 for the Treatment of Non-Hodgkin’s Lymphoma.
Authors: Andrew G. Polson, Shang-Fan Yu, Kristi Elkins, Bing Zheng, Suzanna Clark, Gladys Ingle, Dion Slaga, Lynne Giere, Changchun Du, Jean-Philippe Stephan, Judy Young, Richard Vandlen, Wesley Chang, Suzie Scales, Sarajane Ross, Dan Eaton, Allen Ebens
Journal: Blood (2006)
Platelet activation and thrombosis: Studies in a patient with essential thrombocythemia
Authors: P. Nurden, C. Bihour, M. Smith, J.M. Raymond, A.T. Nurden
Journal: American Journal of Hematology (1996)

Recent advances permit the detection of activated piatelets using specific monoclonal antibodies and flow cytometry.Nevertheless, there are few reports in which activated platelets have been studied over a period of time in patients at risk for thrombosis.Our patient S.D. has essential thrombocythemia and a prothrombotic state manifested in two major thrombotic episodes involving the portal vein and a mesenteric artery.investigation revealed both spontaneous aggregation and hyperaggregabiiity in response to ADP and the presence of activated platelets in platelet-rich plasma as revealed by flow cytometry.Interestingly, the activated platelets were recognized by an anti-RIBS ("receptor-induced binding site") monoclonal antibody that recognized bound fibrinogen but not by antibodies reactive with antigens whose presence on the platelet surface was secretion dependent.Treatment with aspirin inhibited spontaneous platelet aggregation but had little effect on the activated platelet profile.A change of therapy to ticlopidine suppressed expression of platelet activation markers.Treatment with ticlopidine has continued for 1 year so far without further thrombotic complications.
OBSERVATIONS ON THE BLOOD CYTOLOGY IN EXPERIMENTAL SYPHILIS
Authors: Paul D. Rosahn, Louise Pearce, Albert E. Casey
Journal: The Journal of Experimental Medicine (1934)

Weekly observations were made on the blood cytology of seven syphilitic and nine normal control rabbits. Each animal was examined seven times prior to and fifteen times after inoculation of the experimental group. Comparisons were made between the mean blood cell values obtained from all counts on the experimental and control groups in the preinoculation and postinoculation periods. The mean blood cell formula of the syphilitic group for the 3½ month period after inoculation was significantly different from the preinoculation mean values observed in the same group in the following respects: higher total white cell count, platelet count, neutrophil count, and monocyte count, and lower lymphocyte count. The mean blood cell formula of the syphilitic group for the 3½ month period after inoculation was significantly different from the mean blood cell formula of the normal control group in the same time interval in the following respects: higher total white cell count, platelet count, neutrophil and monocyte counts, and lower lymphocyte count. From these results it was concluded that during the period of disease activity, the blood cytology of rabbits infected with Tr. pallidum is characterized by an increase in the total white cell count, the platelet, neutrophil, and monocyte counts, and a decrease in the lymphocyte count from normal values. These changes were statistically significant.
BOOK REVIEWS
Authors: WALTER J. URBA
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Principles of Cancer Biotherapy. Robert K. Oldham, ed. New York: Raven Press, 1987, 512 pp. $89. WALTER J. URBA WALTER J. URBA Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 13, 5 July 1989, Page 1039, https://doi.org/10.1093/jnci/81.13.1039 Published: 05 July 1989
Programs in Medical Education Sponsored by Government Agencies
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family medicine
Authors: R. D. Gillette
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The challenges placed before family medicine by Edmund D. Pellegrino, MD (240:132, 1978), raise issues beyond those intended by the author. It is undoubtedly true that "every innovation in medical education must ultimately prove itself academically," since the medical schools largely control medical education, but this situation may be less than ideal from the standpoint of meeting the public's health care needs. Family medicine has much to gain by involvement in medical education: a rich heritage of information, teaching methods, and intellectual discipline; knowledge and skills from many medical specialties; and access to medical students interested in becoming family physicians. However, certain hazards must be recognized. One of these becomes apparent as we examine the first of Dr Pellegrino's challenges: "Does [family medicine] have a method and intellectual content not central to any other clinical discipline?" Much effort is being expended to develop an intellectual base for
Endoscopic ultrasound
Authors: F. Gleeson, M. Levy
Journal: Endoscopy (2011)

The American College of Chest Physicians guidelines for lung cancer staging recommend that patients with abnormal-appearing lymph nodes on computed tomography (CT) or positron emission tomography (PET) imaging or centrally located tumors without mediastinal lymph nodes should undergo invasive staging. Endoscopic ultrasonography (EUS) and endobronchial ultrasound (EBUS) have largely replaced mediastinoscopy for this purpose. EUS is routinely performed in other settings such as esophageal cancer patients to enhance locoregional staging accuracy, partly through the use of fine-needle aspiration (FNA) for sampling malignant-appearing lymph nodes. The use of FNA in this setting is aided by the discovery of EUS lymph node features that predict malignant infiltration, including lymph node size > 1 cm, round shape, hypoechoic echogenicity, and well-circumscribed border. The possible utility of these lymph node EUS features for evaluating lung cancer has yet to be evaluated.
Crab Walk
Authors: Ryan E. Childers
Journal: Annals of Internal Medicine (2010)

Ad Libitum21 December 2010Crab WalkRyan E. Childers, MDRyan E. Childers, MDFrom Johns Hopkins Bayview Medical Center, Baltimore, MD 21224.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-12-201012210-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Gnarled, grizzled, the old fisherman guides his large frameOnto his good knee, his cigarette expertly balancedOn the edge of his lip, his sinewy musclesFurther distorting sun-bleached tattoos telling of timesPast, women loved, wars both personal and global.His hand penetrates the murky depths, tugging on ropesAttached to an iron cage, now tomb to three blue crabs,Four flopping fish, and an empty Pepsi bottle.Grunting, he hoists his humble load with care,His arthritic joints groaning louder than his belly.Any happy return to happier times in ... Author, Article, and Disclosure InformationAffiliations: From Johns Hopkins Bayview Medical Center, Baltimore, MD 21224.Current Author Address: Ryan E. Childers, MD, Bayview Medical Center, Johns Hopkins University, 4940 Eastern Avenue, Mailbox 102, Baltimore, MD 21224. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 December 2010Volume 153, Issue 12Page: 852KeywordsCataractsCrabsFallsKneesMusclesMuscular dystrophies ePublished: 21 December 2010 Issue Published: 21 December 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A System of Legal Medicine.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A BRIEF CONTRIBUTION TO THE BIOLOGY OF THE MALARIAL PARASITE.
Authors: R. S. WOODSON
Journal: JAMA (1897)

The biology of the malarial parasite is one of the most interesting subjects in modern medicine, the accurate understanding of which is rendered exceedingly difficult to the average practitioner by reason of the conflicting opinions of competent observers as to its life cycle, the function of its various forms and their pathogenic relationship to the various clinical malarial manifestations. The segmentation of the intra-corpuscular parasites, their escape into the plasma of the blood and their reappearance as fresh hyaline bodies in the red corpuscles as described by Golgi, is believed to be the method of reproduction. The evidence that this is the method of reproduction rests upon the very great resemblance between the antecedent and resultant hyaline bodies, and further upon their identity with the fresh hyaline forms that make their appearance just at this time in other red blood corpuscles. This theory of reproduction is rendered somewhat hypothetic by
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia
Authors: Szymon Klossowski, Hongzhi Miao, Katarzyna Kempinska, Tao Wu, Trupta Purohit, EunGi Kim, Brian M. Linhares, Dong Chen, Gloria Jih, Eric Perkey, Huang Huang, Miao He, Bo Wen, Yi Wang, Ke Yu, Stanley Chun-Wei Lee, Gwenn Danet-Desnoyers, Winifred Trotman, Malathi Kandarpa, Anitria Cotton, Omar Abdel-Wahab, Hongwei Lei, Yali Dou, Monica Guzman, Luke Peterson, Tanja Gruber, Sarah Choi, Duxin Sun, Pingda Ren, Lian-Sheng Li, Yi Liu, Francis Burrows, Ivan Maillard, Tomasz Cierpicki, Jolanta Grembecka
Journal: Journal of Clinical Investigation (2019)

The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays a critical role in acute leukemias with translocations of the MLL1 gene or with mutations in the nucleophosmin 1 (NPM1) gene. As a step toward clinical translation of menin-MLL1 inhibitors, we report development of MI-3454, a highly potent and orally bioavailable inhibitor of the menin-MLL1 interaction. MI-3454 profoundly inhibited proliferation and induced differentiation in acute leukemia cells and primary patient samples with MLL1 translocations or NPM1 mutations. When applied as a single agent, MI-3454 induced complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia, including patient-derived xenograft models, through downregulation of key genes involved in leukemogenesis. We also identified MEIS1 as a potential pharmacodynamic biomarker of treatment response with MI-3454 in leukemia, and demonstrated that this compound is well tolerated and did not impair normal hematopoiesis in mice. Overall, this study demonstrates, for the first time to our knowledge, profound activity of the menin-MLL1 inhibitor as a single agent in clinically relevant PDX models of leukemia. These data provide a strong rationale for clinical translation of MI-3454 or its analogs for leukemia patients with MLL1 rearrangements or NPM1 mutations.
Athletic echoes.
Authors: N H Silverman, C L Roge
Journal: Circulation (1977)

the chronicity of severe heart disease.There was therefore a very definite correlation between the preoperative history and the histologic observations.On the other hand Aschoff bodies did not have a prognostic significance because acute rheumatic fever is a self-limiting dis- order of months' duration and operation was performed at variable times during the acute rheumatic episode.Murphy's patients were all operated upon before 1957.Up until at least 1950, acute rheumatic fever was the commonest cause of death in childhood, adolescence and young adulthood.2Today acute rheumatic fever is very rare, is much milder when it does occur, and deaths from it are almost unknown.It is therefore to be expected that Aschoff bodies will rarely be seen at a time when rheumatic valvular subjects have clinical disability sufficient to justify operation.It is to be anticipated that the Aschoff body will soon be of historical interest only, but we should not mimic our political associates who continuously rewrite history.