tbuckley/cabot-search huggingface dataset:
262. Delivery of CCL21 to Metastatic Disease Improves the Efficacy of Adoptive T Cell Therapy
Authors: Uma Thanarajasingam, Laura Sanz Alcober, Rosa Maria Diaz, Jian Qiao, Luis Sanchez-Perez, Timothy Kottke, Jill Thompson, Richard Vile
Journal: Molecular Therapy (2006)

Adoptive T cell transfer has achieved a significant measure of clinical success, notably in the setting of advanced melanoma. However, therapeutic efficacy is limited by factors such as poor T cell survival post-adoptive transfer, and inefficient trafficking to tumor sites. Here we report that the chemokine CCL21 can enhance the efficacy of adoptive T cell therapy in a mouse model of melanoma. Based on our novel observation that CCL21 is highly chemotactic for activated OT-1 T cells in vitro, and down-regulated the expression of the lymph-node homing molecule CD62L, we hypothesized that tumor cell-mediated expression of this chemokine might be useful in recruiting, and retaining, adoptively transferred T cells to the sites of tumor growth. Mice bearing multiple metatstatic tumors stably transduced to express CCL21 survived significantly longer following adoptive T cell transfer than mice bearing non CCL-21-expressing tumors. However, although we could not detect increased trafficking of the adoptively transferred T cells to tumors per se, tumor- expressed CCL21 promoted the survival and cytotoxic activity of the adoptively transferred T cells both in vitro and in vivo, and led to the priming of anti tumor immunity following T cell transfer. To translate these observations into a protocol of real clinical utility, we demonstrated that adsorption of a retrovirus encoding CCL21 to OT-1 T cells prior to adoptive transfer, increased the therapeutic efficacy of a subsequently administered dose of OT-1 T cells, resulting in a cure of metastatic disease and the generation of immunological memory in the majority of treated mice. In summary, we have shown that it is possible to deliver CCL-21 in a truly systemic manner, in a fully immuno-competent host, using adoptively transferred, antigen specific T cells, without the need to access any tumor sites for direct delivery of the CCL-21 gene. In this way, CCL-21 can significantly enhance the therapeutic efficacy of subsequently administered doses of T cells. Therefore, in addition to other manipulations, such as the use of T cell supportive cytokines, additional vaccinations and lymphodepletion, CCL-21 is a promising and novel reagent for use in enhancing the efficacy of adoptive T cell transfer protocols.
Survival of herpes simplex virus in water specimens collected from hot tubs in spa facilities and on plastic surfaces
Authors: L. S. Nerurkar
Journal: JAMA (1983)

Several health spas were closed temporarily because of possible nonvenereal spread of herpes simplex virus (HSV) in spa water at these facilities. We collected water specimens from two health spas and studied them for (1) the presence of HSV; (2) bromine (Br<sub>2</sub>), chlorine (Cl<sub>2</sub>), and pH levels; and (3) the ability of HSV to survive in water. No HSV could be isolated from the spa water specimens. Spa water had high levels of Cl<sub>2</sub>and Br<sub>2</sub>, tap water specimens had low levels of Cl<sub>2</sub>, and distilled water had no detectable Cl<sub>2</sub>or Br<sub>2</sub>. The addition of spa water to laboratory stock virus immediately inactivated the virus. The HSV survived four hours in the tap water and 24 hours in distilled water. The survival of HSV appeared to be related to the free halogen content of water. To approximate the conditions of survival of HSV on plastic-coated benches and seats in spa facilities, HSV was placed on plastic surfaces in a humid atmosphere at 37 to 40 °C. The virus was found to survive up to 4.5 hours under these conditions. The survival of HSV from human lesions may be different due to the presence of tissue secretions and proteins. Furthermore, transmission may require other factors, such as rubbing of skin or penetration through abrasions. However, survival of significant amounts of virus for 4.5 hours on plastic surfaces suggests that fomites such as these may be nonvenereal routes of HSV transmission. (<i>JAMA</i>1983;250:3081-3083)
Utilization of Data from Human Population Studies for Setting Air Quality Standards: Evaluation of Important Issues
Authors: Michael David Lebowitz
Journal: Environmental Health Perspectives (1983)

Epidemiological studies of community populations are highly relevant to the process of setting national ambient air quality primary standards, as criteria for those standards are the protection of human populations against adverse effects on health. Nevertheless, because of the difficulties of performing adequate community population studies of a quality commensurate with the needs of standard setting, the use of data derived from studies is problematic. This paper addresses the important issues of appropriate exposure assessment and health assessment, and discusses the problems of multiplex variables and colinearity as they are critical in assessments of exposure-effect relationships. It is concluded that a major problem in the use of data from such studies for standard setting is not necessarily one of scientific reliability or validity, but arises from the attempt of translating adequate science into policy decisions.
Pathology
Authors: Ashton B. Morrison
Journal: JAMA (1994)

This second edition of Rubin and Farber's<i>Pathology</i>textbook exemplifies why the first edition was a success. It is magnificently illustrated with clear photographs, both black-and-white and color, and graphic diagrams demonstrating disease mechanisms, often with good, clear tables incorporated. The striking graphics bestow an impression of movement on the mechanisms of disease, which is an important concept for the early student of pathology. Despite a large cast of contributors, the text is uniformly lucid, well organized, and terse enough to meet the comprehensive needs of today's overburdened students. Educational overload has been skillfully contained by subdivisions of the text into clearly headed brief discussions of matters of common relevance. Headings are emphasized with color and large type size. The contributors and editors have clearly recognized that their book is meant to enhance student learning, and they have presented their material accordingly. Their success ensures that the second edition will
Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice
Authors: Fei Wang, Yasuo Okamoto, Isao Inoki, Kazuaki Yoshioka, Wa Du, Xun Qi, Noriko Takuwa, Koichi Gonda, Yasuhiko Yamamoto, Ryunosuke Ohkawa, Takumi Nishiuchi, Naotoshi Sugimoto, Yutaka Yatomi, Kunitoshi Mitsumori, Masahide Asano, Makoto Kinoshita, Yoh Takuwa
Journal: Journal of Clinical Investigation (2012)

In the Results section, in the paragraph titled "Cavnoxin decreases both BP and vascular tone in an eNOS-dependent manner," the figure citation was incorrect.The correct sentence appears below.Cavnoxin, but not AP, reduced KCl-mediated contractility of the vessels and the contractile response to the α adrenoceptor agonist, phenylephrine (PE) (Figure 5A).The authors regret the error.
Pediatrics
Journal: New England Journal of Medicine (1947)

Attitudes toward Infant CareThe care of infants is largely influenced by physiologic and psychiatric knowledge, much of which has accumulated in the past few years. Fundamental in this care are the notion that healthy newborn infants are physiologically equipped for survival in the environment into which they are born and, secondly, the certainty that, for the building up of a healthy new personality, a firm and comfortable relation between the infant and its mother is essential.A suitable environment presupposes a mother or mother's substitute whose main concern is the welfare of the baby. She should be one person . . .
Early Postpartum Mood as a Risk Factor for Postnatal Depression in Nigerian Women
Authors: Abiodun Adewuya
Journal: American Journal of Psychiatry (2006)

Objective: This report explored early postpartum mood changes and their correlation with postnatal depression in African women. Method: Scores on the Maternity Blues Scale and the Edinburgh Postnatal Depression Scale for 478 women on the fifth day postpartum were compared with the women’s Research Diagnostic Criteria diagnosis at 4 and 8 weeks postpartum. Results: The Maternity Blues Scale and the Edinburgh Postnatal Depression Scale scores at day 5 postpartum were found to reliably predict the diagnosis of depression at 4 and 8 weeks postpartum. Conclusions: African women at risk of postnatal depression can be identified in the early postnatal period by incorporating simple screening methods.
Nonhormonal Treatment Regimens Substantially Improve Overall Survival in Patients with Metastatic Breast Cancer
Journal: JNCI Journal of the National Cancer Institute (2008)

Nonhormonal Treatment Regimens Substantially Improve Overall Survival in Patients with Metastatic Breast CancerNonhormonal treatment regimens, including anthracycline-based regimens and taxanes, have improved overall survival in women with advanced (metastatic or recurrent inoperable) breast cancer over the last 35 years, according to a systematic review published December 9 in the Journal of the National Cancer Institute .Numerous regimens have been tested in advanced breast cancer.However, each of the trials has compared only a few regimens, making it diffi cult for researchers and clinicians to know the relative merit of the individual regimens.To learn how regimens compare with one another, John P. A. Ioannidis, M.D., of the University of Ioannina School of Medicine in Greece and colleagues performed a meta-analysis of 128 clinical trials that included 148 comparisons between regimens and that enrolled 26,031 women with advanced breast cancer.The investigators used single-agent chemotherapy with old non-anthracycline drugs as the baseline for comparison within their meta-analysis.
Klinefelter syndrome and cancer. A family study
Authors: H. T. Lynch
Journal: JAMA (1974)

The well-established relevance of familial and evidently genetic factors for breast cancer in women may be generalized to all individuals whose chromosome complements include two X chromosomes. Thus, an individual with a masculine phenotype, whose chromosome complement includes a Y chromosome as well as two X chromosomes may face the same risk as his sisters who lack a Y chromosome. The familial (genetic?) factor for cancer diathesis determines a relatively high risk for breast cancer in an individual with two X chromosomes. The familial factor for cancer diathesis is transmitted to and through individuals of both sexes. The usually sex-limited (ie, to females) manifestations of the relevant familial factor is evidently not directly related to gender but rather to interaction with an effect of the occurrence of two X chromosomes. Further medical genetic studies of Klinefelter patients and their families seem warranted in order to better appraise cancer epidemiology. (<i>JAMA</i>229:809-811, 1974)
Effectiveness of Olanzapine, Quetiapine, and Risperidone in Patients With Chronic Schizophrenia After Discontinuing Perphenazine: A CATIE Study
Authors: T. Stroup
Journal: American Journal of Psychiatry (2007)

Objective: The relative effectiveness of newly started antipsychotic drugs for individuals with schizophrenia may depend on multiple factors, including each patient’s previous treatment response and the reason for a new medication trial. This randomized, double-blind study compared olanzapine, quetiapine, and risperidone in patients who had just discontinued the older antipsychotic perphenazine. Method: Subjects with schizophrenia (N=114) who had been randomly assigned to and then discontinued perphenazine in phase 1 of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia study were reassigned randomly to double-blinded treatment with olanzapine, 7.5–30.0 mg/day (N=38); quetiapine, 200–800 mg/day (N=38); or risperidone, 1.5–6.0 mg/day (N=38). The primary aim was to determine whether there were differences among these three treatments in effectiveness, as measured by time to treatment discontinuation for any reason. Secondary outcomes included reasons for treatment discontinuation and measures of drug tolerability. Results: The time to treatment discontinuation was longer for patients treated with quetiapine (median, 9.9 months) and olanzapine (7.1 months) than with risperidone (3.6 months). There were no significant differences between treatments on discontinuation due to inefficacy, intolerability, or patient decision. Conclusions: Among this group of patients with chronic schizophrenia who had just discontinued the older antipsychotic perphenazine, quetiapine and olanzapine were more effective than risperidone, as reflected by longer time to discontinuation for any reason. In the context of other results from the CATIE study, the effectiveness and acceptability of antipsychotic drugs appears to vary considerably according to clinical circumstances.
Dental Infection
Authors: A. G. SCHNACK
Journal: Annals of Internal Medicine (1929)

Article1 July 1929Dental InfectionA. G. SCHNACK, A.M., M.D.A. G. SCHNACK, A.M., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-1-63 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe subject of focal infection, especially with regard to dental infection, still holds the lively interest of both medical and dental professions. Vitamin deficiency as a basic cause for numerous of our pathological dental conditions has stimulated new interest in this field and new conceptions have perhaps resulted. Our theories of vitamin activity are constantly undergoing alteration, as new facts seem to become established. My aim here is to briefly sketch some of these newer ideas in their relationship to dental infection, and perhaps show how they apply in a medical way. The vastness of the material will not allow...References1 PRICE WA: Calcium, Its Activation, Utilization and Metabolism. Jour. Am. Dental Assn. Vol. XV, No. 4. Google Scholar2 BODECKER CF: Enamel Lamellae. Jour. Am. Dent. Assn. Vol. XV, No. 10. Google Scholar3 BANTING RW: The Relation of Bacillus Acidophilus to Dental Caries. Jour. Am. Dent. Assn. Vol. XV, No. 7. Google Scholar4 BARKER LF: Relationship of Oral Conditions to Conditions Elsewhere. Jour. Am. Dent. Assn. Vol. XV, No. 3. Google Scholar5 MELLANBY M: The Influence of Diet on the Structure of Teeth. Physiological Review, Vol. VIII, No. 4. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Honolulu, Hawaii PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDie Krankheiten des MagensDental Infection 1 July 1929Volume 3, Issue 1Page: 63-69 Issue Published: 1 July 1929 PDF DownloadLoading ...
National Policies Affecting Rural Life: Proceedings of the Sixteenth American Country Life Conference, Blackburg, Virginia, August 1-4, 1933. Cloth
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mr. Shaw on doctors
Authors: S. L. Wilens
Journal: JAMA (1966)

When the eminent playwright George Bernard Shaw was beginning to age, he wrote a play called<i>Back to Methuselah</i>which he considered to be his masterpiece since in it he portrayed his idea of Utopia. The elite characters in this play lived to be 300 years old and all were brilliant conversationalists just like the author. They apparently did little else but converse. An aging man is likely to regard young adults as mere children. Shaw at this time believed that a proper adolescence lasted 78 years and that a man could not become an adult unless he turned 100. However, when the great dramatist reached his 90's he seems to have lost his zest for a three-century life span. In fact, he lost his enthusiasm for most of the opinions that he had propounded during his career. But his antagonism towards doctors persisted. In the preface to<i>Far Fetched</i>
Hepatology highlights
Authors: Jean‐François Dufour
Journal: Hepatology (2015)

Sofosbuvir/Ledipasvir in Patients With CirrhosisHow potent and safe is the sofosbuvir/ledipasvir (SOF/ LDV) combination in compensated patients with cirrhosis with hepatitis C virus (HCV) genotype 1? Rajender Reddy et al. performed a post-hoc analysis of seven clinical trials to analyze 513 patients.The sustained virological response (SVR) at 12 weeks (SVR12) was 96% in treatment-na€ ıve patients and "only" 90% in treatment-experienced patients.Forty-seven percent of the treatment-experienced patients had been exposed to a protease inhibitor.Treating treatment-experienced patients for 24 weeks with SOF/LDV combination increased the SVR12 to 98%, or adding ribavirin for a treatment duration of 12 weeks increased the SVR12 to 96%.Overall, there were only five severe adverse events.These findings indicate that the SOF/LDV combination is a potent, safe regimen in patients with compensated cirrhosis.(
Hepatitis C
Authors: Ala I. Sharara
Journal: Annals of Internal Medicine (1996)

To review the virology, epidemiology, pathogenesis, natural history, clinical manifestations, and current treatment of hepatitis C virus (HCV) infection.The MEDLINE database (1966 to 1996) was searched for English-language articles and abstracts on HCV and non-A, non-B hepatitis. Papers cited in relevant primary articles were also reviewed.More than 500 original and review articles were evaluated, and the most relevant were selected.Data were extracted and reviewed by all authors.In most patients, HCV infection results in chronic hepatitis. The disease is insidious and subclinical but may progress over decades into end-stage liver disease and hepatocellular carcinoma, which makes HCV cirrhosis a leading indication for orthotopic liver transplantation. Current diagnostic methods are highly sensitive and specific, and quantitative assessment of viral load may help to predict and monitor response to treatment. The only available therapeutic option is interferon, and this agent is effective in only a small subset of patients.Infection with HCV is a significant public health problem that has important clinical and financial consequences. The tailoring of specific therapy according to viral load or genotype, better patient selection, and use of combination drug regimens may improve the chance of viral clearance and sustained biochemical and histologic response. Further understanding of the basic virology of HCV and the exact mechanisms of viral persistence and tissue injury is needed to help define future therapeutic and preventive strategies.
The LD50
Authors: J. G. Llaurado
Journal: JAMA (1985)

<h3>To the Editor.—</h3> It is disturbing to read Dr Hubbard and Ms Young's<sup>1</sup>letter inThe Journalurging medicine "to develop modern<i>nonanimal</i>alternatives for all toxicity testing" (my italics). Groups like Friends of Animals and mobilization for Animals (there are about 400 of them worldwide) generate a strong emotional appeal for the alleged poor, victimized laboratory animal. Many television and movie celebrities have backed these movements and added glamour and generous contributions to this cause. These groups are now well organized with plenty of money at their disposal. The public should know, however, that from 12 to 20 million unclaimed animals are put to death in the United States each year. The County of Los Angeles alone destroys 6,000 to 10,000 animals per month, often at taxpayers' expense. Of this number, only 3% are needed for medical research. Thus, the life of the vast majority is terminated with
Reply
Authors: Kristian Wachtell, Mika Lehto, Eva Gerdts, Michael Hecht Olsen, Björn Hornestam, Björn Dahlöf, Hans Ibsen, Stevo Julius, Sverre E. Kjeldsen, Lars H. Lindholm, Markku S. Nieminen, Richard B. Devereux
Journal: Journal of the American College of Cardiology (2005)
Neuroanatomy: A Guide for the Study of the Form and Internal Structure of the Brain and Spinal Cord
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lectures ON THE ANATOMICAL AND PHYSIOLOGICAL PRINCIPLES UNDERLYING THE TREATMENT OF INJURIES TO MUSCLES, BONES, AND JOINTS: Given at the Royal College of Surgeons of England, November-December, 1917
Authors: A. Keith
Journal: BMJ (1918)

Hall first announced his discovery of reflex action, at a November meeting of the Zoological Society of London in 1832, hie was a man of 42, a consult- ing physician with a considerable practice in London.He was born of a Saxon Midland stock-withi an infusionI of that hybrid strain whichi reached England thirouglh Nor- mandy.His fathlee was a cotton spinner and bleachier
Comment on Suissa. Lower Risk of Death With SGLT2 Inhibitors in Observational Studies: Real or Bias? Diabetes Care 2018;41:6–10
Authors: Marcus Thuresson, Matthew A. Cavender, Alex Z. Fu, John P. Wilding, Kamlesh Khunti, Reinhard W. Holl, Anna Norhammar, Kåre I. Birkeland, Marit Eika Jørgensen, Eric Wittbrodt, Niklas Hammar, Peter Fenici, Mikhail Kosiborod, Mikhail Kosiborod, Matthew A. Cavender, Alex Z. Fu, John P. Wilding, Kamlesh Khunti, Anna Norhammar, Kåre Birkeland, Marit Eika Jørgensen, Reinhard W. Holl, Niklas Hammar, Peter Fenici, Niki Arya, Kyle Nahrebne, Karolina Andersson-Sundell, Johan Bodegård, Betina T. Blak, Sara E. Dempster, Kelly Bell, Eric T. Wittbrodt, Markus F. Scheerer, Hanne Løvdal Gulseth, Bendix Carstensen, Marcus Thuresson, Esther Bollow, Luis Alberto García Rodríguez, Lucia Cea Soriano, Oscar Fernández Cantero, Ellen Riehle, Brian Murphy
Journal: Diabetes Care (2018)