tbuckley/cabot-search huggingface dataset:
Adverse non-drug reactions.
Journal: BMJ (1969)

JOUN.leprosy, and at last a new and unusual drug called Lampren (B.633; G 30.320) has been introduced.Lampren was one of the many phenazine derivatives that were synthesized and shown to be very active against Myco- bacterium tuberculosis in vitro and in mouse infection by V. C. Barry and his colleagues at Trinity College, Dublin, in 1957.7 8 When given by mouth in a micronized form Lam- pren, a red dye, was shown to be absorbed from the gut, to be present in the blood, and to be deposited in body fat and in cells of the reticuloendothelial system, where it remained for months.9Nevertheless Lampren was also found to be ineffective against tuberculosis in man.Fortunately S. G. Browne included the drug in his chemotherapeutic trials in leprosy at Uzuakoli in Eastern Nigeria, and these established that Lampren was therapeutically active.10 11These findings were amply confirmed throughout the world.12 13The Medical Research Council's studies on patients with dapsone
Bryce's Visiting List and Pocket Record, Good for any Month or Year.
Journal: JAMA (1888)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea University Medical Library JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
ACUTE EPIDEMIC POLIOMYELITIS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Upcoming Events
Authors: M. S. Simon
Journal: JNCI Journal of the National Cancer Institute (1992)

Upcoming Events Get access Michael S. Simon Michael S. Simon Division of Hematology and Oncology Wayne State University School of Medicine3990 John R. Street Detroit, MI 48201 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 12, 17 June 1992, Pages 980–985, https://doi.org/10.1093/jnci/84.12.980 Published: 17 June 1992
Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR
Authors: F LIN
Journal: Hepatology (1996)

Autoantibodies from rare patients with primary biliary cirrhosis (PBC) recognize LBR, or lamin B receptor, an integral membrane protein of the inner nuclear membrane. Human LBR has a nucleoplasmic, amino-terminal domain of 208 amino acids followed by a carboxyl-terminal domain with eight putative transmembrane segments. Autoantibodies against LBR from four patients with PBC recognized the nucleoplasmic, amino-terminal domain but not the carboxyl-terminal domain. Immunoblotting of smaller fusion proteins demonstrated that these autoantibodies recognized a conformational epitope(s) contained within the stretch of amino acids from 1 to 60. These results, combined with those of previous studies, show that autoepitopes of nuclear membrane proteins are located within their nucleocytoplasmic domains and that autoantibodies from patients with PBC predominantly react with one domain of a protein antigen. This work also provides further characterization of anti-LBR antibodies that have found utility as reagents in cell biology research.
Omitted Minus Sign
Journal: JAMA Psychiatry (2016)

Antonio C. Lopes, MD, PhD; Benjamin D. Greenberg, MD, PhD; Miguel M. Canteras, MD; Marcelo C. Batistuzzo, PsyD; Marcelo Q. Hoexter, MD, PhD; André F. Gentil, MD; Carlos A. B. Pereira, PhD; Marinês A. Joaquim, RN; Maria E. de Mathis, PsyD; Carina C. D’Alcante, PsyD, MSc; Anita Taub, PsyD, MSc; Douglas G. de Castro, MD; Lucas Tokeshi, MD; Leonardo A. N. P. C. Sampaio, MD; Cláudia C. Leite, MD, PhD; Roseli G. Shavitt, MD, PhD; Juliana B. Diniz, MD, PhD; Geraldo Busatto, MD, PhD; Georg Norén, MD, PhD; Steven A. Rasmussen, MD, PhD; Eurípedes C. Miguel, MD, PhD
Simian virus 40 and human pleural mesothelioma
Authors: C Mulatero, T Surentheran, J Breuer, R M Rudd
Journal: Thorax (1999)

<h3>BACKGROUND</h3> An aetiological role for Simian virus 40 (SV40) in malignant mesothelioma has been suggested from studies in the USA and the UK but results have been conflicting. A study was undertaken to look for evidence of SV40 in stored tissue samples from pleural mesotheliomas. <h3>METHODS</h3> DNA was extracted from paraffin embedded tissue. The presence of DNA was established by amplification of a 250 bp product from the betaglobin gene. Primers PYV.F and PYV.R were used in a concentration of 50 per mol each per reaction to amplify a 172 bp fragment of a conserved region of SV40 that codes for a portion of large T antigen that is common to SV40 and other polyoma viruses. <h3>RESULTS</h3> Twelve of the 17 samples contained amplifiable betaglobin DNA. None of the samples (0/12, 95% CI 0 to 26.5%) was positive for the polyoma large T antigen. <h3>CONCLUSIONS</h3> These results do not lend any support to the hypothesis that SV40 infection may be aetiologically relevant to the increasing incidence of mesothelioma in the UK.
Highlights
Journal: JAMA Pediatrics (2018)

Rosen and colleagues conducted an epidemiologic assessment and cost analysis of a 2013 measles outbreak in New York City, New York, and found 58 cases of measles infection and 3351 exposed contacts, with 78% of the age-eligible cases unvaccinated because of patient refusal or intentional delay.The total direct costs to the New York City Department of Health and Mental Hygiene were $394 448, and 10 052 personnel hours were consumed responding to and controlling the outbreak.Their findings have important implications for the public health costs of vaccine refusal.
Myoglobinuria following lightning stroke
Authors: J. W. Yost
Journal: JAMA (1974)

PHYSICIANS should be alerted to two facets of lightning injury: first, that it may be accompanied by myoglobinuria that has clearly been shown to precipitate acute tubular necrosis and renal failure in some individuals, and second, that the resuscitation of individuals "killed" by lightning, as previously emphasized by Jex-Blake1 and Taussig,<sup>2</sup>is eminently successful, with almost complete recovery. <h3>Report of a Case</h3> A 14-year-old teen-ager was struck on the right shoulder by a bolt of lightning. He was successfully resuscitated by defibrillation 15 minutes later. When first seen at the Kansas University Medical Center (KUMC) 2 1/2 hours after the incident, the patient was actively moving all four extremities, rolling his eyes, but was unresponsive to vocal and other sensory stimuli. Results of physical examination showed feathery flaring burns and singed hair that extended from the right shoulder to both ankles (Fig 1 and 2). In addition, the patient's right
Wound Disruption
Authors: T. L. Hyde
Journal: JAMA (1963)

<h3>To the Editor:</h3> —I want to protest your wasting my time with "Disruption of Abdominal Wounds" by L. S. Mann, et al (<i>JAMA</i><b>180</b>:1021-1023 [June 23] 1962). I don't know when I have seen a worse abuse of statistical presentation. The figures presented have little significance or validity. None of them contributes to the knowledge of wound disruptions because none is accompanied by control figures of incidence in the whole group. <h3>Examples:</h3> Disruption with a right lower quadrant muscle-splitting incision did not occur. In neither patient? In (3,988 less 109) 3,779 patients? Or in just how many patients was this incision used? Why bother to tell me that 30 patients in the sixth decade had disruption, if I am not told how many patients there were in this age group? Why bother to tell me that 80% of the cases of disruption were after operations on patients with benign
Volunteer physicians for Vietnam. A six-year review
Authors: G. Smilkstein
Journal: JAMA (1972)

Statistics released by the Vietnamese Ministry of Health in 1965 indicated that there were 1,300 physicians in South Vietnam. Of this number, approximately 1,000 had duties with the military or government which precluded their service to the civilian population. A review of the location of the remaining 300 physicians available to the civilian population indicated that most of the physicians were in Saigon while a lesser number were in the large cities of Hue, Danang, Nha Trang, and Can Tho. The other provincial capitals had a negligible number of practicing physicians. At the request of the government of Vietnam, the United States initiated a program to help augment this small force of Vietnamese physicians at the province level through the use of volunteer physicians for shortterm medical aid. On July 1, 1965, the People-To-People Foundation, under a contract with the United States Agency for International Development (USAID) initiated a program to
Effectiveness of a regional bone marrow donor program
Authors: J. McCullough
Journal: JAMA (1988)

Because many potential bone marrow transplant patients lack HLA-matched siblings, there is growing interest in carrying out transplantations using matched, unrelated volunteer donors. We developed a local registry of 2147 informed donors who consented to be listed in the Bone Marrow Donor Registry. This registry was used to carry out 420 donor searches for 351 patients. The initial computer search involved matching for HLA-A and HLA-B locus antigens only because most donors had not been typed for HLA-DR antigens. Depending on the degree of HLA-A and HLA-B antigen mismatching allowed, suitably matched (HLA-DR—identical, mixed lymphocyte culture nonreactive) donors were located for 6% to 16% of patients. This resulted in 13 bone marrow transplants. This study shows that a small, local bone marrow donor registry can locate donors for a few patients; however, a large network involving an expanded number of donors will be necessary to allow an extensive evaluation of unrelated bone marrow transplantation. (<i>JAMA</i>1988;259:3286-3289)
Abstract 177: Follow-up Study of Thrombus in Coronary Aneurysms due to Kawasaki Disease.
Authors: Atsuko Suzuki
Journal: Circulation (2015)

The features of MR coronary angiography (MRCA) are able to detect arterial walls and thrombus in aneurysms clearly by using the sequences of black blood methods. Up to now 262 patients have been followed up by MRCA(the average 3.5 times ±2.3 times), The duration of the follow up is 4.7years±3.3years, During the periods, the coronary arterial lesions have changed as follows; decreased size of aneurysms in 116 patients out of the 262 (44.3%), enlargement of aneurysm in 2 (0.8%), newly appeared or progressed degree of localized stenosis in 26 (9.9%), appearance of occlusion in 5 (1.9%), recanalized vessels in 20 (7.6%). These changes are related to thrombus formation, thrombolysis and thickening of arterial walls. The thrombus often change their locations in the aneurysm, sizes, even disappear and some of them develop to recanalized vessels. Thin membranes in aneurismal lumen and tiny polyps on the intima were often detected (Fig),These constructions and thrombus in aneurysms are observed to be still changeable even more than 2 decades after the onset of Kawasaki disease. Therefore, MRCA is the most convenient for following up CAL frequently and noninvasively.
Mosquito-Transmitted Malaria—Michigan, 1995
Journal: JAMA (1996)

During the 19th and early 20th centuries, malaria was endemic in many areas of the United States. Although indigenous transmission was interrupted by the 1940s, recent outbreaks in New Jersey, New York, and Texas have underscored the potential for reintroduction of mosquitoborne transmission of malaria in the United States. This report summarizes the investigation of a case of Plasmodium vivax malaria diagnosed during September 1995 in a resident of Michigan with no history of international travel; the findings of the investigation indicated that the route of transmission was probably through the bite of a locally infected Anopheles spp. mosquito.
PHILADELPHIA LETTER.
Authors: None J. V. S.
Journal: JAMA (1883)

<h3>(FOR THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION.)</h3> One of the principal topics of conversation in medical circles here is the newJournal of the American Medical Association. Its importance to the profession is appreciated, and the idea that founded it, is considered an advanced one, both as regards medical journalism and scientific medical literature. A medical journal that shall be truly representative is needed. And by representative I mean a journal national in character. Such a journal, if the standard of excellence is maintained, will do much to elevate medical journalism by its competition with the periodical medical literature of the day. Although occupying a province peculiarly its own, the bounds of a journal of this character must, of necessity, overlap somewhat that of medical journalism at large. Professor Ellerslie Wallace, who for so many years has occupied the chair of obstetrics at the Jefferson Medical College, has resigned,
BOOK REVIEWS
Authors: A. I. RADIN
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article BOOK REVIEWS Get access The Biology of Human Leukemia . Alvin M. Mauer , ed. Baltimore : The Johns Hopkins University Press , 1990 , 239 pp. $55. ARTHUR I. RADIN ARTHUR I. RADIN The Johns Hopkins Oncology Center600 N. Wolfe St. Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 11, 6 June 1990, Pages 967–968, https://doi.org/10.1093/jnci/82.11.967 Published: 06 June 1990
Correction: Treatment of osteoporosis with human parathyroid peptide and observations on effect of sodium fluoride
Journal: BMJ (1990)

Iron dextran 50-240 Dosage of 120 [\\\\\\\\120 eryhropoietin 0-IL\\\\\\\\\\\\Y \\\\\\\\\\\\\\51 (IU/kgIweek) 0 4 8 12 16 0 4 8 1216 Weeks of treatment Response to erythropoietin in two patients with multiple myeloma receiving haemodialysis atrophy, interstitial inflammatory changes, and eosinophilic casts characteristic of myeloma.Two courses of melphalan and prednisolone had no appreci- able effect on his serum and urine M component concentrations, and because they were fairly low he was kept under observation only.He received nine units of blood between September 1988 and November 1989.
Acid-Base
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liposomal Cytarabine and Daunorubicin (CPX-351) in Combination with Gemtuzumab Ozogamicin (GO) in Relapsed Refractory (R/R) Patients with Acute Myeloid Leukemia (AML) and Post-Hypomethylating Agent (Post-HMA) Failure High-Risk Myelodysplastic Syndrome (HR-MDS)
Authors: Jorge M. Ramos Perez, Tapan M. Kadia, Guillermo Montalban-Bravo, Christopher B. Benton, Stefan Faderl, Koji Sasaki, Kiran Naqvi, Jorge E. Cortes, Naval G. Daver, Courtney D. DiNardo, Elias Jabbour, Gautam M. Borthakur, Hind Al Azzawi, Naveen Pemmaraju, Marina Y Konopleva, Sherry A. Pierce, Nitin Jain, Maro Ohanian, Guillermo Garcia-Manero, Michael Andreeff, Hagop M. Kantarjian, Farhad Ravandi, Yesid Alvarado
Journal: Blood (2019)
Individualized treatment for alcohol withdrawal. A randomized double-blind controlled trial
Authors: R. Saitz
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess the effect of an individualized treatment regimen on the intensity and duration of medication treatment for alcohol withdrawal. <h3>Design.</h3> —A randomized double-blind, controlled trial. <h3>Setting.</h3> —An inpatient detoxification unit in a Veterans Affairs medical center. <h3>Patients.</h3> —One hundred one patients admitted for the treatment of alcohol withdrawal who could give informed consent and had no history of seizures or medication use that might alter the clinical course of withdrawal. <h3>Intervention.</h3> —Patients were randomized to either a standard course of chlordiazepoxide four times daily with additional medication as needed (fixed-schedule therapy) or to a treatment regimen that provided chlordiazepoxide only in response to the development of the signs and symptoms of alcohol withdrawal (symptomtriggered therapy). The need for administration of "as-needed" medication was determined using a validated measure of the severity of alcohol withdrawal. <h3>Main Outcome Measures.</h3> —Duration of medication treatment and total chlordiazepoxide administered. <h3>Results.</h3> —The median duration of treatment in the symptom-triggered group was 9 hours compared with 68 hours in the fixed-schedule group (<i>P</i>&lt;.001). The symptom-triggered group received 100 mg of chlordiazepoxide, and the fixed-schedule group received 425 mg (<i>P</i>&lt;.001). There were no significant differences in the severity of withdrawal during treatment or in the incidence of seizures or delirium tremens. <h3>Conclusions.</h3> —Symptom-triggered therapy individualizes treatment, decreases both treatment duration and the amount of benzodiazepine used, and is as efficacious as standard fixed-schedule therapy for alcohol withdrawal. (<i>JAMA</i>. 1994;272:519-523)
THE ASSOCIATION AND ITS JOURNAL ABROAD.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adult onset of cow's milk protein allergy with small-intestinal mucosal IgE mast cells
Authors: F. S. Levy, A. J. Bircher, J.-O. Gebbers
Journal: Allergy (1996)

We report a female patient with adult onset of cow's milk protein allergy. For 1 year, she experienced repeated gastrointestinal symptoms and had a single exercise-induced anaphylactic reaction. In addition to positive skin tests and specific IgE to milk proteins and a positive challenge test, immunohistochemistry of the small intestine showed a marked increase of IgE-positive mast cells. This finding is highly specific and could provide an additional tool for diagnosing cow's milk protein allergy and possibly also other food allergies.
Détection des polypes festonnés cliniquement pertinents au cours d’une coloscopie de dépistage: résultats de 7 centres allemands dans le cadre du programme de dépistage du cancer colo-rectal
Journal: Endoscopy (2018)

Les polypes festonnés sont divisés en trois entités: les polypes hyperplasiques, les adénomes festonnés traditionnels et les adénomes festonnés sessiles. L’analyse anatomopathologique souffre d’un manque de reproductibilité pour différencier ces 3 entités. C’est pour s’affranchir de cette variabilité interindividuelle histologique que la célèbre équipe hollandaise (IJspeert et collègues) a proposé le concept de “polypes festonnés cliniquement pertinents” (clinically relevant serrated polyps, ou crSPs). Ces lésions comprennent les polypes festonnés d’au moins 10 mm quelle que soit leur localisation ou d’au moins 5 mm situés en amont de l’angle gauche, ces 2 types de polypes festonnés semblant les plus à risque de dégénérescence.
Cutaneous alternariosis
Authors: N. BANG PEDERSEN, P.-A. MARDH†, T. HALLBERG, N. JONSSON
Journal: British Journal of Dermatology (1976)

Two patients with cutaneous alternaria infection are presented. In both patients the skin lesions were characterized by multiple non‐healing ulcers covered with dry crusts. Although the skin changes were macroscopically alike in the two patients, differences in the histology were seen. Both patients had primary debilitating diseases. A review of the literature is presented and revealed an additional ten cases of cutaneous alternariosis. Methods for the isolation of Alternaria and the susceptibility of the fungus to antimycotic drugs are presented.
Donor Lymphocyte Infusions for Chronic Myeloid Leukemia Relapsing after Allogeneic Stem Cell Transplant: May We Predict Graft vs Leukemia without Graft vs Host Disease?.
Authors: Cesare Guglielmi, Stefania Bergantini, Simona Iacobelli, Anja van Biezen, Eduardo Olavarria, Alois Gratwohl, Antonius V.M.B. Schattenberg, Leo F. Verdonck, Dietger W. Niederwieser, T.M. de Witte
Journal: Blood (2006)