tbuckley/cabot-search huggingface dataset:
Stress Electrocardiograms
Authors: Jack R. Harnes
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Robb and Seltzer (234:722, 1975) have again demonstrated that the amount and character of ST depressions in Double-Master tracings are of varying prognostic significance. In his editorial duscussion of postexercise electrocardiograms (234:745, 1975), Spodick did not point out that, even though more strenuous tests show a higher incidence of myocardial ischemia, one major obstacle to their wider use, especially by life insurance physicians, is the lack of uniformity in their performance, reporting, and interpretation. Bicycle or treadmill exercise to submaximal or maximal stress and various combinations of orthodox or unorthodox leads recorded at varying times during or after continuous or intermittent exercise, combined with different criteria for a positive test, result in such diverse tests that no valid long-term mortality statistics can be derived by combining studies from various centers into a sufficiently large group for actuarial analysis. The standardization of stress electrocardiograms, perhaps under the aegis
Practical Spectroscopy
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A history of the Joint Commission on Accreditation of Hospitals
Authors: J. S. Roberts
Journal: JAMA (1987)

THE HISTORY of the Joint Commission on Accreditation of Hospitals is a story of the health professions' commitment to patient care of high quality in the 20th century. The story began on a summer day in England in 1910. While riding back to London from a visit to a tuberculosis sanitarium, Dr Ernest Codman was explaining his end-result system of hospital organization to Dr Edward Martin. According to Dr Codman, his system would enable a hospital to track every patient it treated long enough to determine whether or not the treatment was effective. If the treatment was not effective, the hospital would then try to find out how to prevent similar failures in the future. Dr Martin responded that he thought Dr Codman's system was one of the important reasons why an American college of surgeons should be established: An American College would be a fine thing if it could
Nagging doubt, public opinion offer obstacles to ending 'cluster' studies
Authors: C. Raymond
Journal: JAMA (1989)

BIRTH DEFECTS reported by users of video display terminals at the<i>Toronto Star</i>. Cancers in football players practicing and playing in the Meadowlands Stadium in New Jersey. Leukemias in children living near some drinking wells in Woburn, Mass. Health departments have invested large sums of time and energy investigating these so-called clusters, epidemiologists countless hours calculating risk ratios, attorneys endless weeks litigating civil suits. Now, say investigators in Atlanta, Ga, at the Centers for Disease Control, it's time the public health community calls a halt to many of those investigations. In the last 5 years, the Centers for Disease Control has pretty much gotten out of the business of cluster investigation itself, turning over the work to state health departments, says Glyn G. Caldwell, MD, formerly at the Atlanta facility and now deputy director of the Arizona Department of Health Services, Phoenix: "We just weren't getting anywhere. They weren't productive
PLoS Medicine Issue Image | Vol. 3(7) July 2006
Journal: PLoS Medicine (2006)

The cover refers to an ongoing outbreak of chikungunya fever in the Indian Ocean. The disease is caused by the chikungunya virus. Sylvain Brisse and colleagues report the first sequence analysis and comparison of viral gene sequences from the current outbreak with those of earlier virus isolates. The genome sequences of viruses isolated from six patients and partial sequences isolated from 121 patients at different locations and during different stages of the outbreak reveal unique and evolving molecular features of the viruses responsible for the largest outbreak of the disease to date. Image Credit: Images taken from Brisse et al.
Management of varicella exposure in a neonatal intensive care unit
Authors: S. V. Lipton
Journal: JAMA (1989)

We describe the management of an exposure to varicella in a neonatal intensive care unit. Thirty-seven hospital staff members with negative histories of varicella were tested by enzyme-linked immunosorbent assay for antibody to varicella zoster; all were seropositive. None were restricted from clinical duties, were given varicella-zoster immune globulin, or developed disease. Although only 1 of 38 cord serum samples from normal term infants was seronegative, 10 of 22 neonatal intensive care unit infants were seronegative. The high rate of seronegativity among these patients was related to chronological age older than 2 months and to multiple transfusions of packed red blood cells. This probably reflects natural catabolism of maternal antibody and loss of antibody in serum removed from these infants for diagnostic tests. Infants lacking antibody were given varicella-zoster immune globulin. Antibody levels following administration of varicella-zoster immune globulin were directly related to the dose administered. (<i>JAMA</i>. 1989;261:1782-1784)
Frederick Morgan
Authors: T. Smeeton
Journal: BMJ (2012)

Bupropion, an efficacious antidepressant and smoking cessation agent, inhibits dopamine and norepinephrine transporters (DAT and NET, respectively). Recently, bupropion has been reported to noncompetitively inhibit α3β2, α3β4, and α4β2 nicotinic acetylcholine receptors (nAChRs) expressed in<i>Xenopus</i> oocytes or established cell lines. The present study evaluated bupropion-induced inhibition of native α3β2∗ and α3β4∗ nAChRs using functional neurotransmitter release assays, nicotine-evoked [<sup>3</sup>H]overflow from superfused rat striatal slices preloaded with [<sup>3</sup>H]dopamine ([<sup>3</sup>H]DA), and nicotine-evoked [<sup>3</sup>H]overflow from hippocampal slices preloaded with [<sup>3</sup>H]norepinephrine ([<sup>3</sup>H]NE). The mechanism of inhibition was evaluated using Schild analysis. To eliminate the interaction of bupropion with DAT or NET, nomifensine or desipramine, respectively, was included in the superfusion buffer. A high bupropion concentration (100 μM) elicited intrinsic activity in the [<sup>3</sup>H]DA release assay. However, none of the concentrations (1 nM–100 μM) examined evoked [<sup>3</sup>H]NE overflow and, thus, were without intrinsic activity in this assay. Moreover, bupropion inhibited both nicotine-evoked [<sup>3</sup>H]DA overflow (IC<sub>50</sub> = 1.27 μM) and nicotine-evoked [<sup>3</sup>H]NE overflow (IC<sub>50</sub> = 323 nM) at bupropion concentrations well below those eliciting intrinsic activity. Results from Schild analyses suggest that bupropion competitively inhibits nicotine-evoked [<sup>3</sup>H]DA overflow, whereas evidence for receptor reserve was obtained upon assessment of bupropion inhibition of nicotine-evoked [<sup>3</sup>H]NE overflow. Thus, bupropion acts as an antagonist at α3β2∗ and α3β4∗ nAChRs in rat striatum and hippocampus, respectively, across the same concentration range that inhibits DAT and NET function. The combination of nAChR and transporter inhibition produced by bupropion may contribute to its clinical efficacy as a smoking cessation agent.
Endometriosis-Reply
Authors: Daniel W. Cramer
Journal: JAMA (1986)

<h3>In Reply.—</h3> Several issues about which Dr Redwine requests clarification were discussed in the text of our article. The cases in this study were selected from a broader study of infertility due to many different causes. Women with endometriosis formed a unique and definable group that was the subject of this report. The study design did not permit us to recruit women with other signs of endometriosis unless they also were infertile. Dr Redwine is correct that age is a potential confounding factor, but we recognized this and controlled for it by multivariate analysis. This means that the associations discussed held in groups of cases and controls who were the same age. All controls who said they had a clinical diagnosis of endometriosis were excluded. It was clearly not feasible to perform laparoscopy on the remaining controls to be certain that they did not have undiagnosed endometriosis. We do not
Leukocyte Agglutinins
Authors: Robert L. Krebsbach
Journal: JAMA (1961)

This monograph deals with the author's work in the field, a critical review of the literature, and an evaluation as to the occurrence and significance of leukocyte agglutinins in humans. It is quite apparent after review that certain areas of discussion are omitted. The reason is pointed out by the author in the introduction when he states that "many of the problems touched upon are unsolved or have not even been experimentally approached as yet." The chapter on the method of determining leukocyte agglutinins is sound and would serve as a stepping stone for initial investigation by someone new to the field, or for critical comparison of other techniques already in use. The latter is brought out even further in a subsequent chapter. Two chapters are devoted to the occurrence and significance of leukocyte agglutinins. These are most interesting to anyone not particularly interested in technique of investigation. Several possibilities
Interferon therapy in LKM1 positive patients with chronic hepatitis C : follow-up by a quantitative radioligand assay for CYP2D6 antibody detection
Authors: J.C. Duclos-Vallée, M. Nishioka, N. Hosomi, K. Arima, A. Leclercq, J.F. Bach, A.M. Yamamoto
Journal: Journal of Hepatology (1998)
Chronic plumbism in children. Diagnosis by hair analysis
Authors: L. Kopito
Journal: JAMA (1969)

The determination of lead in scalp hair is a valuable diagnostic aid in chronic or mild lead intoxication particulary when the other clinical or laboratory evidence is of questionable diagnostic quality. This continuously growing tissue accumulates and stores lead for long periods and may be used for estimating the time and duration of the exposure. Hair is easy to obtain, store, transport, and analyze and may provide a practical means for finding little children who may have been exposed to lead.
The coming oversupply of neurologists in the 1980s. Implications for neurology and primary care
Authors: M. Menken
Journal: JAMA (1981)

AMONG medical specialists, neurologists at this time make relatively little contribution to primary care, and for this reason a projection of future manpower needs for neurologists is of special interest and importance. There is a range of data<sup>1</sup>that suggests that some communities have become saturated with neurologists, so that physicians graduating from neurology residency programs at this time find it difficult to practice solely as neurologic consultants in these communities, although they might wish to do so. In the following analysis, the assumption is made that the present supply of practicing neurologists seek to function in the health care delivery process as consultants for other physicians. Because of the limited supply of neurologists in relation to the demand for neurologic care, this has certainly been true in the past. The heuristic value of this assumption is that a large increase in neurologic manpower may result in an undesirable
Sunlight sensitivity from oral contraceptives
Authors: L. R. Erickson
Journal: JAMA (1968)

Oral contraceptives may cause sunlight sensitivity. An eruption similar to polymorphic light eruption developed in a 31-year-old Negro woman who was taking norethynodrel with mestranol (Enovid E). Symptoms and lesions cleared after stopping the drug administration, only to reappear after trial with other oral contraceptives. Estrogen alone caused the condition to reappear, suggesting that this was the active agent in causing sunlight sensitivity. The "pill" can be added to the growing list of photosensitizing drugs.
TREATMENT OF RINGWORM OF THE SCALP BY THE ROENTGEN RAYS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Specialty Abstracts
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ABSORPTION AND EXCRETION OF IRON
Authors: P. W. C.
Journal: Annals of Internal Medicine (1940)

Editorial1 November 1940THE ABSORPTION AND EXCRETION OF IRONP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-5-930 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough iron is an element vitally essential to all vertebrates, relatively little has been known regarding its exchange in the body. Iron unquestionably must be absorbed from the gastrointestinal tract, and there is good reason to believe that this occurs largely in the upper part of the small intestine. The details of its excretion are much less clear. Iron is normally present in the urine in only minute insignificant traces, and by exclusion it has been assumed that excretion occurs through the intestine. Some histological evidence has been advanced to support this view, but it is impossible to determine in...1 HEMMELER G: Serumeisen und Eisentherapie, Schweiz. med. Wchnschr., 1939, lxix, 316. Google Scholar2 MOORE CV: Studies in iron transportation and metabolism: IV. Observations on the absorption of iron from the gastrointestinal tract, Jr. Clin. Invest., 1939, xviii, 553-580. CrossrefGoogle Scholar3 LINTZEL W: Zur Frage des Eisenstoffwechsels. V. Ueber den Eisenbedarf des Menschen, Ztschr. f. Biol., 1929, lxxxix, 342. Google Scholar4 MCCANCEWIDDOWSON RAEM: The absorption and excretion of iron following oral and intravenous administration, Jr. Physiol., 1938, xliv, 148-154. CrossrefGoogle Scholar5 HAHN PF: Radioactive iron and its excretion in urine, bile and feces, Jr. Exper. Med., 1939, lxx, 443-451. CrossrefGoogle Scholar6 HAHN PF: Radioactive iron and its metabolism in anemia. Its absorption, transportation and utilization, Jr. Exper. Med., 1939, lxix, 739-753. CrossrefGoogle Scholar7 HAHN PF: The utilization of iron and the rapidity of hemoglobin formation in anemia due to blood loss, Jr. Exper. Med., 1940, lxxi, 731-736. CrossrefGoogle Scholar8 FOWLERBARER WMAP: The treatment of iron deficiency anemias, Jr. Am. Med. Assoc., 1939, cxii, 110. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1940Volume 14, Issue 5Page: 930-933KeywordsExcretionGastrointestinal tractSmall intestineUrine ePublished: 1 December 2008 Issue Published: 1 November 1940 PDF downloadLoading ...
Report of Surgical Cases Occurring in the Cheltenham Hospital, from 1830 to 1840
Authors: C. J. Hawkins
Journal: BMJ (1844)

The Inistitution in which the following cases occurred, consisted of a Dispensary to which a Casualty Hospital was attached, for the reception of accidents and cases for surgical operation, and occasionally urgent cases, both Medical and Surgical, were admitted, the nature of which prevented their being properly treated at their own houses.In the year 1839 the establishment was con- verted into a General Hospital and Dispensary.The Medical Staff at present consists of two phy- sicians and two surgeons for the Hospital, and three surgeons and three physicians for the Dispensary, and a house surgeon and apothecary.The cases were, for the most part, witnessed by myself during the time I was a pupil, and since I )have settled in the town, many were treated by myself, under the direction of the surgeons of the establishment, to whom I gladly avail myself of an ,opportunity of publicly acknowledging many per- sonal acts of kindness, botb in professional and private life.Arm Fore-art Shoulde Thigh
Council on drugs. List No. 100. New names
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Pediatrics
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Miriam Cintron, Paul Ruich, Diane Cannon, Connie Manno, Fred Marshall, Laura Copyreaders, Catherine Adamcyzk, Jan Alden, Mary Clavey, Gillian Coerver-Connolly, Laura Dickens, Juliann King, Donna Tarsney, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Lenette Gardner-Gullens, Fanny Brown, Paul Frank, Rachell Lozano, Michaela Mark, Kathryn Muskovich, J Neff, Kate Pezalla, Gale Saulsberry, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Christopher Hastings, Craig Mccaffrey, Reuben Rios, Ronna Henry, Staff Bird, Alison Burke, Cassio Lynm, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Jann Ingmire, Deanna Bellandi, Jim Periodical, Thomas Staff, Monica Smith, Jeffery Bonistalli Manager, Kathy Staff, Mirna Monal, Tim Melroy, Thalia Moss, Tem Harrier, Susan Henning, Mark Thornbury, Tricia Castellano, Saskia Bolore, Gretchen Linder, Brian Mccartney, Rebecca Haas, Christine Hearne, Irma Lara, Audra Lawlor, Scott Marketing, Matt Herron, Elizabeth Solaro, Geoffrey Flick, Paul Gee Managers, Rick Bell, Michael Mcgraw, Sara Nagy, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Sue Sherrill, Brian Shields Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Diane Darnell, Colleen Kelly, Chris Meyer, Jaye Mize, Annemarie Neff, Sean O'donnell, Sean Ohlson, Phil O'leary, Ryan Patella, Susan Price, Denise Steinhauser, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Brenda Chandler-Grayer, Scott Curl, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, James Madara, Bernard Hengesbaugh, Dimitri Christakis, Washington Joffe, Ron Keren, Suzanne Shuey, Benjamin French, Peter Cummings, Samir Shah, Howard Bauchner, Frederick Rivara, Matthew Davis, Ann Arbor, Cherrie Boyer, San Francisco, Robert Bradley, Maria Britto, John Campo, Aaron Carroll, Indiana Frank, Joseph Chaloupka, Mitchell Cohen, Chris Feudtner, Kathleen Janz, Iowa City, Terry Klassen, Joyce Lee, Michigan Michelle, Huckaby Lewis, Maryland Saiman, New York, York Samir, Martha Sola-Visner, Jean-Claude Carel, Shabir Madhi, Ben Marais, Frank Oberklaid, Susan Sawyer, Joan-Carles Surís
Journal: JAMA Pediatrics (2014)