tbuckley/cabot-search huggingface dataset:
Endocrinology
Authors: Martin L. Nusynowitz
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heterocyclic Amines: Occurrence and Prevention in Cooked Food
Authors: Saida Robbana-Barnat, Maurice Rabache, Emmanuelle Rialland, Jacques Fradin
Journal: Environmental Health Perspectives (1996)

This article deals with the mutagenic heterocyclic amines, especially the aminoimidazoazaarenes family, isolated from cooked foods. The conditions which lead to their occurrence in foods are discussed. This formation primarily depends on the characteristics of the food, such as the type of the food and the presence of precursors, water, and lipids. Secondarily, it depends on the cooking modes where the temperature is considered to be the most important factor involved in their formation. As their formation during cooking represents a health risk, we present some ways and means to limit their formation by alternative cooking methods that tend to decrease heterocyclic amine concentrations in foods as they are implicated in cancer risks.
Abstract 244: Inhibition of atypical PKC signaling enhances the sensitivity of glioblastoma cells towards Temozolomide therapy
Authors: Avijit Dey, Rekha Patel, Tracess Smalley, Wishrawana Sarathi Ratnayake, Anisul Islam, Mildred Acevedo-Duncan
Journal: Cancer Research (2019)

Abstract Glioblastoma is a highly aggressive brain cancer which has a mean survival rate of only 12 months. Current treatment options of glioblastoma include chemotherapy and limited surgical resection. Temozolomide (TMZ) is the current therapeutic choice for chemotherapy but has severe limitations due to development of resistance that occurs by genetic modification and constitutive activation of several other pathways. Therefore, to overcome Temozolomide resistance and to prevent recurrence of the disease a more effective therapeutic approach is required. One of the signaling pathways that contribute to the aggressive behavior of glioma cells is the activation of PKC signaling. Of the various PKC isoforms, the atypical PKCs, PKC ζ and ι were found to be over-expressed in glioblastoma tissue samples compared with normal brain tissue and high atypical PKC levels were correlated with increased cellular proliferation and invasiveness of glioma cells. [4-(5-amino-4-carbamoylimidazol-1-yl)-2, 3-dihydroxycyclopentyl] methyl dihydrogen phosphate also known as ICA-1 was used as a specific inhibitor of PKC-ι and [8-hydroxynaphthalene-1,3,6-trisulfonic acid] also known as ζ-Stat was used as a specific inhibitor of PKC- ζ. T98G and U87 glioblastoma cells were treated with ICA-1 monotherapy (7.5µM), ζ-stat monotherapy (10 µM), TMZ monotherapy at varying doses, TMZ combined with ICA-1 (7.5µM) and TMZ combined with ζ-stat (10 µM) for five consecutive days and analyzed for cell viability by WST assay. Results exhibited that ICA (7.5µM) when combined with TMZ showed significantly increased cytotoxicity compared to TMZ monotherapy. Annexin-V/PI assay revealed that combination treatment with TMZ and ICA nucleotide (7.5µM) significantly increased the number of dead cells and the number of cells undergoing late apoptosis when compared to TMZ monotherapy. This study offers the first evidence for the novel combination of ICA-1 with TMZ to induce robust apoptosis in a Caspase-3 mediated mechanism. Scratch assay results also showed that inhibition of PKC-ζ by ζ-Stat lead to decreased invasion compared to control. Our studies suggest that atypical PKCs particularly PKC-ι might be an important therapeutic target in the treatment of glioblastoma. Citation Format: Avijit Dey, Rekha Patel, Tracess Smalley, Wishrawana Sarathi Ratnayake, Anisul Islam, Mildred Acevedo-Duncan. Inhibition of atypical PKC signaling enhances the sensitivity of glioblastoma cells towards Temozolomide therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 244.
Redundant Information in Text and Incorrect Reference
Authors: Allison Kaup, Jasmine Nettiksimmons, Kristine Yaffe
Journal: JAMA Neurology (2015)

greater neuropathology in aging.Indeed, there is strong evidence that diabetes mellitus is a risk factor for cognitive decline and dementia. 2As Dr Kawada mentioned, some studies examining both diabetes mellitus and APOE ε4 status have found interactive effects (eg, Bangen et al 3 ).In referring to our findings, Dr Kawada stated, "Regarding diabetes mellitus, the authors could not elucidate it as a significant predictor of cognitive resilience."In fact, we did find associations between diabetes mellitus and cognitive resilience, especially among black APOE ε4 carriers.Our random forest results suggested that being free of diabetes mellitus is one of the most important predictors of cognitive resilience among black APOE ε4 carriers.A follow-up analysis (which estimated the independent effects of each of the variables identified as important predictors in the random forest analyses) showed that, among black APOE ε4 carriers, being free of diabetes mellitus was associated with 1.45 times increased odds of cognitive resilience.Although this did not reach statistical significance (perhaps owing to sample size/power limitations), we think the substantial effect size is suggestive of an important effect.For white APOE ε4 carriers, although we found a statistically significant bivariate association between diabetes mellitus and cognitive resilience, our random forest analysis did not identify diabetes mellitus as one of the strongest predictors of cognitive resilience.We were surprised by this, and the reason for the apparent discrepancy between this and results of prior related studies is unclear.It is possible that our study's focus on a relatively unique outcome measure (cognitive resilienceie, optimal cognitive trajectory) and application of a novel multivariable analysis (ie, random forest analysis) may have contributed to differing results from previous studies.Additionally, Dr Kawada suggested we "consider including baseline psychological factors as predictors of cognitive resilience."We agree that psychological factors are important to examine in this context.We were able to investigate depression, self-reported sleep, and recent experience of negative life events in our study; future studies may benefit from a more comprehensive assessment of psychological functioning or objective sleep measures.
Emergence delirium
Authors: R. D. Bastron
Journal: JAMA (1967)

Emergence delirium or excitement is a fairly common anesthetic problem, some possible consequences of which are exemplified in the following case report. A 63.5-kg (140-lb) healthy 22-year-old man was scheduled to have a pedicle graft from his chest to an old burned area on his left hand. At 7 AM he was given, intramuscularly, morphine, 10 mg, and scopolamine, 0.4 mg. He was awake and still somewhat apprehensive when he arrived in the operating room at 8 AM. Anesthesia was induced at 8:15 with sodium thiopental, 250 mg, and maintained with halothane, nitrous oxide, and oxygen. By 10 he was in the recovery room having recovered swallowing and gag reflexes but unresponsive to verbal stimulation. Two or three minutes later he was thrashing about sufficiently to partially detach the flap from his hand and disrupt the skin graft on his chest wall. He was returned to the operating room and
Papular mucinosis
Authors: C. M. Shapiro
Journal: JAMA (1970)

The thickened skin with papules and plaques of a patient with papular mucinosis is explained by focal accumulations of hyaluronic acid and fibroblastic proliferation in the dermis. Findings from protein analysis demonstrated an associated aberration in protein production that appears to be characteristic of this disease: an abnormal peak in the position beyond that of γ-globulin on serum protein electrophoresis and immunologic studies which shows the γ-globulin to be IgG with only L type light chains. The etiology is unknown, but the condition may represent an immunologic response to an unknown antigenic stimulus.
Survival of zidovudine-treated patients with AIDS compared with that of contemporary untreated patients. Italian Zidovudine Evaluation Group
Authors: S. Vella
Journal: JAMA (1992)

<h3>Objective.</h3> —To assess the long-term effectiveness of zidovudine (AZT) in patients with acquired immunodeficiency syndrome (AIDS). This assessment has never been adequately done because controlled clinical trials were stopped early and survival comparisons were made with historical controls. <h3>Design.</h3> —Nonrandomized contemporary observational study of patients treated and not treated with zidovudine. <h3>Setting.</h3> —Twenty-three AIDS treatment centers throughout Italy that reported cases to the National Registry of AIDS Cases between July 1987 and March 1988. <h3>Patients.</h3> —One hundred fifty-nine zidovudine-treated and 112 untreated patients with AIDS, the majority of whom had acquired human immunodeficiency virus (HIV) infection through intravenous drug use. <h3>Outcome Measures.</h3> —Median survival and 1- and 2-year survival for treated and untreated groups, as estimated using the Kaplan-Meier method. Cox proportional hazards regression analysis was also used to identify independent predictors of survival among the variables studied. <h3>Results.</h3> —Patients were similar with respect to CD4/CD8 ratio, age, sex, clinical and immunological status at diagnosis, and source of HIV infection. After 24 months, survival was 45.9% (95% confidence interval [Cl], 36.1% to 55.7%) in the treated group and 20.5% (95% Cl, 12.6% to 28.3%) in the untreated group, with median survival of 21.2 and 9.6 months, respectively. <h3>Conclusions.</h3> —Possible biases of this study include imperfect matching for clinical status and better overall medical care of treated patients. Nevertheless, we believe that the observed differences in survival were primarily due to zidovudine treatment. (<i>JAMA</i>. 1992;267:1232-1236)
Points: Electrocardiographic chest wall mapping in the diagnosis of coronary artery disease
Authors: A M Salmasi, E M M Besterman
Journal: BMJ (1983)

write: Dr Lightman (6 August, p 422) has missed the point.We were not reviewing the variety of lesions that might provoke hot flushes.The object of our case presentation (23 July, p 262) was the objective demonstration that climacteric flushing in a man was associated with circulatory responses virtually identical to those we had shown during the meno- pausal hot flush.'Every blush is not a flush, however, and until the phenomena reported in different circumstances in either sex are recorded by tech- niques capable of following the rapid circulatory changes that occur during the hot flush our under- standing of the mechanisms responsible for the menopausal hot flush will remain obscure.
A GOVERNMENT INVESTIGATION OF WATER SUPPLIES.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POLAND
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Serum-β-Lysine und die antibakterielle Immunität gegen die davon beeinflussten Mikroben
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PRIMARY SYPHILITIC NOSE INFECTION: REPORT OF A CASE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Approaches for Inflammatory Bowel Disease
Authors: J. Duncan Phillips
Journal: JAMA (1990)

<h3>To the Editor.—</h3> We read with interest the article by Cotton<sup>1</sup>that summarizes recent reports of promising new medical therapies for inflammatory bowel disease. We are concerned, however, that the author's enthusiasm about the use of such drugs as mesalamine, hydroxychloroquine sulfate, methotrexate, and cyclosporine appears to have limited him from sounding a note of caution concerning some of the risks of prolonged use of certain drugs for the treatment of ulcerative colitis. We recently reported our clinical experience with the surgical management of 177 consecutive patients with severe ulcerative colitis using the ileoanal pouch procedure.<sup>2</sup>By the time these patients underwent colectomy, 14 (8%) had developed adenocarcinoma of the colon or rectum. In two patients, such extensive carcinoma was found at operation that the endorectal ileal pull-through procedure could not be performed. Pathological changes, ranging from low-grade dysplasia to frank carcinoma, were present in 52 (29%) of
Meta-analysis
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microscopical sequelae of head injury.
Journal: BMJ (1969)

stroke.His own saggestion, that injury resulting from a lightning stroke might be caused by electrostatic forces, is difficult to accept, as it supposes storage of large amounts of electric charge by the body.Recently D. F. Farrell and A. Starr10 have collected from the literature 24 cases of delayed neurological injury with the onset after the accident ranging from " some days " to 24 months in their own case.To explain the delayed onset of the injuries they suggest that the endothelial cells of the blood vessels are damaged by the current, as may happen after irradiation, and that, " if as a result of irradiation or electrically induced protein changes, these cells die or become manifestly abnormal following mitosis there would be a potential region for thrombosis and resultant alteration in blood flow."There is at present, as those authors concede, little sub- stantial evidence to support this hypothesis.However, disturbances of local blood flow, which may be immediate or delayed, after an electric shock have been described.Angina electrica is a recognized sequel of electric shock.J. Marty and his colleagues' published an account of an interesting case of thromboarteritis of the left-brachial artery developing in a 28-year-old radio officer two and a half years after the accidental contact of his left elbow with a capacitor charged at about 5,000 volts, which thereby discharged through his left arm.Thus, although neurological sequelae associated with electric shock have been reported over many years, it has not been possible to explain satisfactorily their cause or causes.The relatively few cases that occur, and their diversity, make detailed pathological and clinical studies difficult.
Chemotherapy of Burkitt's tumor at the University of Ibadan, Nigeria
Authors: V. A. Ngu
Journal: JAMA (1972)

Our work on the chemotherapy of Burkitt's tumor started in 1961 shortly after its recognition as a clinical entity. The management of Burkitt's tumor patients at the University College Hospital, Ibadan, has always been a team effort, with many colleagues in surgery, pediatrics, pathology and hematology participating, and this short report is submitted on their behalf as well. <h3>Cases Treated and Drugs Used</h3> In the past 11 years of the chemotherapy program over 500 patients with Burkitt's tumor have been seen. About 400 patients received some treatment. Various clinical trials were initiated on these cases. Alkylating agents, antibiotics, alkaloids, antimetabolites, and indeed any cytotoxic drug that could be obtained were included in the trial. Of these, the most effective drugs were cyclophosphamide (Cytoxan), mechlorethamine hydrochloride (nitrogen mustard), and methotrexate. <i>Cyclophosphamide</i>was given intravenously at a dose of 10-15 mg/kg of body weight daily for 7-10 days. When the tumor was
Treatment of hyperthyroidism with sodium I 131. Carcinoma of the thyroid after 20 years
Authors: E. M. Kreps
Journal: JAMA (1973)

A 38-year-old woman had papillary carcinoma of the thyroid when surgery for adenomatous goiter was performed 20 years after treatment of hyperthyroidism with sodium iodide I 131. To our knowledge, this is the ninth reported case of microscopically proved cancer following such therapy, and it is the one with the longest interval since treatment.
A program for rural health development
Authors: M. K. DuVal
Journal: JAMA (1972)

The past year has highlighted an increased concern for effective health care delivery and improved consumer health education. Encompassing both areas are the problems of health manpower shortage and, of great urgency to the future of rural health, the problems of distribution. If workable solutions are to be provided, the inadequacies of the interwoven social, economic, and health care delivery systems must be dealt with. To illustrate, I tell the story of Rappahannock County, Virginia, which received publicity recently because it was facing a critical health shortage. The third county in Virginia to lose its last physician, it had been inadequately served for at least three years. Efforts to provide these services had gotten nowhere, and physicians in nearby counties were already laboring under heavy caseloads. The dental care situation was no less severe—the local public health nurse reported that the county has had no dentist for at least two