tbuckley/cabot-search huggingface dataset:
Abstract 15786: Role of Percutaneous Veno-Arterial Extracorporeal Membrane Oxygenation as a Bridge to Long-term Left Ventricular Assist Device
Authors: Koichi Toda, Tomoyuki Fujita, Yusuke Shimahara, Shyunsuke Sato, Junjirou Kobayashi, Osamu Seguchi, Yoshihiro Murata, Masanobu Yanase, Takeshi Nakatani
Journal: Circulation (2011)

OBJECTIVE: Percutaneous veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides emergency circulatory support for cardiogenic shock and can be used as a bridge to left ventricular assi...
Clinical and Prognostic Relevance of Magnetic Resonance Imaging of the Spine in Newly Diagnosed Multiple Myeloma Patients Receiving Autologous Stem Cell Transplantation.
Authors: Patrizia Tosi, Elena Zamagni, Paola Tacchetti, Eugenio Salizzoni, Giulia Perrone, Michela Ceccolini, Annamaria Brioli, Maria C. Pallotti, Lucia Pantani, Antonio de Vivo, Michele Baccarani, Michele Cavo
Journal: Blood (2007)
VITAMIN D AND THE PARATHYROIDS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eosinophilic Gastritis
Authors: Gordon J. Culver
Journal: JAMA (1967)

INFLAMMATORY CHANGES with eosinophilic infiltration of the walls of the gastrointestinal tract may occur in two forms. One is a circumscribed polypoid lesion, and the other consists of a diffuse infiltrative thickening of the walls. The former has been called in general eosinophilic granuloma,<sup>1-3</sup>and in the specific case of the stomach has been described as inflammatory fibroid polyps<sup>4</sup>and gastric fibroma with eosinophilic infiltration.<sup>5</sup>This form is not usually associated with blood eosinophilia or an allergic history. The diffuse type has been recorded in the literature under such names as eosinophilic granuloma,<sup>6</sup>eosinophilic gastroduodenopathy,<sup>7</sup>eosinophilic gastroenteritis,<sup>2,8</sup>and in the specific case of the stomach as eosinophilic gastritis,<sup>9</sup>gastric lesion of Loeffler's syndrome,<sup>10</sup>eosinophilic linitis plastica,<sup>11</sup>and gastric granuloma with eosinophilic infiltration.<sup>12</sup>This type is commonly associated with blood eosinophilia and an allergic history. Both forms have been described as
Highlights
Journal: JAMA Surgery (2014)

Recent evidence suggests that vitamin D status may be a modifiable risk factor for nosocomial infections.Quraishi and coauthors performed a retrospective analysis of 770 patients who underwent Roux-en-Y gastric bypass surgery from a single teaching hospital in Boston, Massachusetts, between 2007 and 2011, to determine whether preoperative 25-hydroxyvitamin D levels are associated with the risk of hospital-acquired infections.In this cohort of patients, a significant inverse association was observed between preoperative vitamin D status and the risk of postoperative infections.
The Medical News Visiting List, 1905. Weekly (Dated for 30 Patients); Monthly (Undated for 120 Patients per Month); Perpetual (Undated for 30 Patients Weekly per Year); 60-Patients (Undated, for 60 Patients Weekly per Year). The Weekly, Monthly and 30-Patient Perpetual Contain 32 Pages of Data and 160 Pages of Classified Blanks. The 60-Patient Perpetual Consists of 256 Pages of Blanks Alone. Each in One Wallet-shaped Book, Bound in Flexible Leather, with Flap and Pocket, Pencil and Rubber, and …
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retraction statement: Equilibrative nucleoside transporter (ENT)‐1‐dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion
Journal: Hepatology (2017)

Retraction Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion Zimmerman, Michael A.; Tak, Eunyoung; Ehrentraut, Stefan F.; Kaplan, Maria; Giebler, Antasia; Weng, Tingting; Choi, Doo-Sup; Blackburn, Michael R.; Kam, Igal; Eltzschig, Holger K.; Grenz, Almut Hepatology. 58(5):1766-1778, November 2013.
Book reviews
Journal: Allergy (1993)

Books reviewed in this article: Lenfant C, Paoletti R, Albertini A (eds.) . Growth factors of the vascular and nervous systems. Functional characterization and biotechnology. Newcombe DS, Rose NR, Bloom JC . Clinical immunotoxicology. Cerio R, Jackson WF(eds) . A colour atlas of allergic skin disorders. Horaud F, Brown F (eds) . Virological aspects of the safety of biological products. Brosnan SF (ed.) . Heat‐shock proteins and gamma delta T cells.
Lehrbuch Der Nerven- Und Geisteskrankheiten. By<i>Prof. W. Weygandt</i>with the collaboration of<i>Professors Gruhle, Kehrer, Kihn, Meggendorfer, Rittershaus, Rosenfeld, Scholz, Stertz, Veraguth, Walter.</i>(Halle: Carl Marhold Verlagsbuchhandlung, 1935.)
Authors: C. B. F.
Journal: American Journal of Psychiatry (1936)
FRESH FRUITS AND VEGETABLES: VITAMINS AND BACTERIA
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Environmental Genome Project: Functional Analysis of Polymorphisms
Authors: F. Peter Guengerich
Journal: Environmental Health Perspectives (1998)

The ultimate goal of the Environmental Genome Project is the improvement of human health on the basis of information about the variations in certain genes. The first phase of the project will involve the selection of the human genes and characterization of the alleles occurring in the American population. However, intelligent use of this information will require analysis of the relevance of the allelic differences. Epidemiology alone will not solve the problem, and mechanistic studies will be required. Factors to be considered in the design of functional analyses are considered in this commentary.
The Nationwide Cancer Genome Screening Project in Japan, SCRUM-Japan GI-screen: Efficient identification of cancer genome alterations in advanced esophageal cancer.
Authors: Yuichiro Nakashima, Takashi Kojima, Hiroki Hara, Ken Kato, Takeshi Kajiwara, Shuichi Hironaka, Hiroshi Nakatsumi, Takeshi Kato, Toshikazu Moriwaki, Daisuke Naruge, Taito Esaki, Naoki Izawa, Shigenori Kadowaki, Takao Tamura, Izumi Miki, Tomohisa Sudo, Shogo Nomura, Kohei Shitara, Atsushi Ohtsu, Takayuki Yoshino
Journal: Journal of Clinical Oncology (2017)

4062 Background: We have conducted the Nationwide Cancer Genome Screening Project in Japan since April 2015 using Next Generation Sequencing in advanced non-colorectal gastrointestinal (GI) cancer (aNon-CRC), called as the SCRUM-Japan GI-SCREEN. The objective is to evaluate the frequency of cancer genome alterations in aNon-CRC and to identify patients who are candidate for clinical trial for corresponding targeting agents. Methods: This study is ongoing with the participation of 20 major cancer centers. Patients with aNon-CRC, including advanced esophageal cancer (aEC), who plan to or receive chemotherapy were eligible. DNA and RNA were extracted from FFPE tumor samples and were analyzed by the Oncomine Cancer Research Panel (OCP) which allows to detect gene mutation, copy number variant (CNV) and fusions across 143 genes in a CLIA certified CAP accredited laboratory. The detected genomic variant data were classified according to genetic drivers of cancer including gain- and loss-of-function or single nucleotide variant based on the Oncomine Knowledgebase. In this presentation, we show the results of aEC cohort. Results: As of October 31 st in 2016, a total of 180 aEC samples were analyzed. The sequence with the OCP was successfully performed in 121 (67.2%). Out of 157 patients except for the 23 patients in which precise data is not collected, the proportion of sample and histology type is followed; surgical specimen 58.0%, squamous cell carcinoma 92.4%. The frequently detected mutations in 114 samples of which results were available were TP53 (77.2%), NFE2L2 (23.7%), CDKN2A (9.6%), PIK3CA (7.0%), RB1 (6.1%), and CNVs were CCND1 (37.7%), EGFR (7.9%), MYC (7.9%), SOX2 (6.1%), ATP11B (5.3%), NKX2-1 (5.3%). ERBB2 amplification was identified in 3 cases (2.6%) and FGFR3-TACC3fusion was identified in one case (0.9%). Conclusions: This nationwide screening system is efficient to detect rare gene alterations in aEC. This novel knowledge provides an intriguing background to investigate new target approaches and represents a progress toward more precision medicine. Clinical trial information: UMIN000016344.
Gonorrhea as a marker of chlamydial infection
Authors: H. Braunstein
Journal: JAMA (1987)

<h3>To the Editor.—</h3> In the April 17, 1987, issue of<i>JAMA</i>, an article by Washington et al<sup>1</sup>argues for cost-effectiveness of combined ampicillin-tetracycline treatment of endocervical gonorrhea because it will eliminate coinfection with<i>Chlamydia trachomatis</i>. The reasoning of the authors is that gonorrhea is a good marker for chlamydial infection because 26% to 48%<sup>2-4</sup>of female patients with gonorrhea also are infected with<i>Chlamydia</i>. Their argument is correct, as far as it goes, but possesses a fatal flaw. The problem is that the figures cited state a converse relationship to that required to determine the efficacy of gonorrhea as a marker for<i>Chlamydia</i>. The significant figure would be the percentage of individuals with chlamydial infections who also have gonorrhea. <h3>Study.—</h3> In the last two months, we received 577 endocervical smears, studied for both organisms by culture for<i>Neisseria gonorrhoeae</i>and direct fluorescent antibody smear (Syva Microtrak) for<i>Chlamydia</i>
“Number needed to treat: enigmatic results for exacerbations in COPD.” Samy Suissa. <i>Eur Respir J</i> 2015; 45: 875–878.
Journal: European Respiratory Journal (2018)

patient per year for each of the two treatment columns (fluticasone/salmeterol and placebo) had been transposed in error.The corrected table is presented below, and the original article has been corrected and republished online.
Essentials of Histology
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of Chronic Renal Failure
Authors: Norman G. Levinsky
Journal: New England Journal of Medicine (1964)

SINCE there is no specific treatment for most forms of chronic renal disease management is directed to ameliorating the manifestations of renal failure and its complications. Such measures do not cure disease, but they often greatly prolong active, useful and comfortable life. The frequency and time of onset of the clinical features of renal failure vary considerably among individual kidney disorders. However, as renal failure progresses, distinctions among specific entities become blurred, and the clinical picture1 of "chronic Bright's disease" becomes relatively uniform, whatever the underlying cause. The magnitude of many symptoms seems to depend on the rate at which . . .
Bacteriology of acute otitis media in adults
Authors: S. E. Celin
Journal: JAMA (1991)

<h3>Objective.</h3> —The objective of this study was to determine the bacteriology of acute otitis media in adults. Although this has frequently been studied in children, no data have recently been reported from adults in the United States. Additionally, information on the prevalence of<i>Haemophilus influenzae</i>as a causative organism in acute otitis media in adults has not been available. <h3>Design.</h3> —Middle-ear aspirates for cultures were obtained by myringotomy from adults meeting entry criteria. <h3>Setting.</h3> —Emergency department, Eye and Ear Hospital of Pittsburgh, Pa. <h3>Patients.</h3> —Thirty-four patients (volunteer sample) met the eligibility requirements. Exclusion criteria included history of chronic otitis media, recent antibiotic therapy, immunosuppressive illnesses, or prior otologic surgery. <h3>Intervention.</h3> —Ten days of oral cefuroxime axetil (250 mg) was prescribed. <h3>Main Outcome Measures.</h3> —Patients were followed closely for at least 6 weeks. Aerobic and anaerobic cultures were incubated and evaluated per the scheduled protocol. <h3>Results.</h3> —<i>Haemophilus influenzae</i>and<i>Streptococcus pneumoniae</i>were grown on culture of specimens from nine and seven patients (26% and 21%), respectively. Twenty-two percent (2/9) of the<i>H influenzae</i>isolates and the single isolate of<i>Moraxella catarrhalis</i>produced β-lactamase (9% overall). <h3>Conclusions.</h3> —The present results suggest that, as in children, amoxicillin would be an appropriate first-line agent for empiric therapy of acute otitis media in adults. Antimicrobials inactive against<i>H influenzae</i>(eg, penicillin V, cephalexin, erythromycin, or tetracyclines) are not appropriate for initial therapy. Antimicrobials with efficacy against organisms producing β-lactamase, such as cefuroxime axetil, which was used to treat the study patients, do not appear to be required for routine initial therapy in adults. However, they would be appropriate when an organism producing β-lactamase is isolated from the middle ear or when a patient fails to improve rapidly on amoxicillin therapy. (<i>JAMA</i>. 1991;266:2249-2252)
Integration of hepatitis B virus and alteration of the 1p36 Region found in cancerous tissue of primary hepatocellular carcinoma with viral replication evidenced only in noncancerous, cirrhotic tissue*1
Authors: D SIMON
Journal: Hepatology (1995)

We have studied the genetic profile of the host genome and hepatitis B virus (HBV) in HBV-associated primary hepatocellular carcinoma (HCC). Comparative analyses of HCC cell line Hep 40 and the original biopsy specimens showed the episomal and replicating form of HBV only in the biopsy specimen from nontumor (NT) cirrhotic liver tissue, where a molecular change in the 1p36 region was detected (NT tissue showed a normal 46XY karyotype). In contrast, only integrated HBV was detected in HCC tumor (T) tissue and Hep 40 cells. Two HBV integration sites were identical in HCC tissue and the hyperdiploid Hep 40 cell line, where genetic alteration in the 1p36 region was identified. These data indicate that viral replication is ongoing only in NT cirrhotic-hyperplastic, chromosomally normal tissue with evidence for genetic instability. Only the tumor cell with altered genotype has virus integrated.
Hypnosis
Authors: T. M. Tyndall
Journal: JAMA (1963)

<h3>To the Editor:</h3> —I have been using hypnosis on my medical, surgical, obstetrical, psychiatric, and pediatric patients since 1954 and can report excellent results. It is true that I have failures in hypnosis as well as failures in penicillin therapy, but I have never encountered any untoward results. My patients with major psychiatric problems are referred to a psychiatrist. I believe that other general physicians who use hypnosis would support my experience.
Morning report. Role of the clinical librarian
Authors: G. L. Barbour
Journal: JAMA (1986)

The educational value of morning report should be enhanced by thorough evaluation of the medical literature. We added a clinical medical librarian (CML) program to our morning report 2% years ago to provide rapid, complete access to reference material relevant to topics discussed in morning report. MEDLINE searches and references are made available on a same-day basis; cumulative lists of these are provided to the staff and house staff at bimonthly and yearly intervals. All house staff used the CML service to some degree and the majority found it to be of value in making patient care decisions. Since the inception of the CML program, the medical library has noted a more than twofold increase in the number of on-line reference searches and a similar increase in requests for searches by house staff. Patient care decisions have been improved through ready access to current medical literature, and the teaching program has been enhanced by the creation of the CML program as an integral part of morning report. (<i>JAMA</i>1986;255:1921-1922)
Phlebotomy Increases Cadmium Uptake in Hemochromatosis
Authors: Agneta Akesson, Per Stal, Marie Vahter
Journal: Environmental Health Perspectives (2000)

The intestinal absorption ofthe nephrotoxic environmental pollutant cadmium increases markedly when iron stores are depleted.This may be mediated by an up regulation ofthe recently identi- fied mucosal transporter DMT1 (Nramp2 or DCT1) for divalent cations.We tested whether the highly increased iron absorption in hereditary hemochromatosis (HH) was accompanied by an enhanced absorption of cadmium and lead.Cadmium and lead in blood and iron status markers were determined in 21 nonsmoking subjects with HH genetically tested for the HFEmutations and in 21 nonsmoking controls matched for age and sex.In subjects with HH on maintenance phlebotomy treatment, blood concentrations of cadmium, but not lead, were significantly higher than in paired controls.There was a strong age-independent positive association between blood cadmium and the number ofyears ofphlebotomy treatment.Blood lead showed a similar but less pronounced consequence of treatment.All HH subjects with lower blood cadmium than the corresponding controls had either no mutation in the HFE gene, were not phlebotomized, or were phlebotomized for only a limited time.Our findings indicate that the treatment rather than the disease increased the cadmium uptake in homozygous HH.Further studies are needed to confirm whether the disease decreased cadmium absorption and whether the absorption was dependent on the genotype.
Gold Therapy in Rheumatoid Arthritis: Report of a Multi-Centre Controlled Trial
Journal: Annals of the Rheumatic Diseases (1960)

rashes, stomatitis, intestinal colic, diarrhoea, vomit- ing, icterus, purpura, and one case of agranulo- cytosis.Renal damage, varying from albuminuria to severe toxic nephritis, and hypoplasia or complete aplasia of the bone marrow were found to be addi- tional serious complications which might occur.Hartfall and others (1937) also noted that gold salts were of doubtful value when used in forms of arthritis other than rheumatoid arthritis.Although these extensive trials had been carefully carried out, the failure to include a control series of This report presents the results during the 18 months after the start of the trial, i.e. to approximately 1 year after each patient had completed the course of treatment.97
Gynecomastia
Authors: G D Braunstein
Journal: New England Journal of Medicine (1993)

Gynecomastia, a benign enlargement of the male breast due to proliferation of the glandular component, is a common clinical condition. It may be an incidental finding on routine examination or may present as an acute unilateral or bilateral painful tender mass beneath the areolar region or as a progressive painless enlargement of the breast. This topic was last reviewed in the Journal in 1980,1 and much of the recent literature has focused on the prevalence, pathogenesis, and treatment of the condition.PrevalencePalpable breast glandular tissue is so prevalent in population studies of men and boys115 (Table 1) that . . .