tbuckley/cabot-search huggingface dataset:
SANITARY UNDERTAKING.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isolated Perfused Lung Preparation for Studying Altered Gaseous Environments
Authors: Rodney A. Rhoades
Journal: Environmental Health Perspectives (1984)

The isolated perfused lung (IPL) preparation is ideally suited to investigate lung dynamics and cellular function, and is easily adapted to investigating biochemical and physiological responses to environmental insults. The IPL offers several advantages which permit one to study endothelial/epithelial interactions that are often disrupted with other model systems (e.g., isolated cells, minces, slices, homogenates, etc.). The IPL developed in our laboratory was devised for the rat lung and allows four lungs to be perfused simultaneously in which control over ventilation, flow, pressure, pH, PO2 and PCO2 can be maintained. Isolated lungs perfused for 1 to 2 hr at a flow rate of 10 mL/min exhibit less that 2% weight gain, maintain normal ATP levels, and exhibit linear substrate uptake. Mechanisms leading to changes in vascular and airway resistance, lipid metabolism, vasoactive hormones, blood gases and changes in vascular permeability mediated by environmental insults can be quantified in the IPL preparation.
Is there a doctor shortage?
Authors: J. K. Cooper
Journal: JAMA (1974)

THE NATIONAL shortage of physicians continues to receive widespread attention. Although many people agree there are locations in need of physicians, it has been difficult to determine satisfactorily the total national need for additional physicians. One often quoted estimate is that of the Federal Bureau of Health Manpower in 1967. They estimated a national shortage of 50,000 physicians.<sup>1</sup>This estimate awakened national concern and spurred Congressional and other action during the last seven years. The estimate is usually accepted without much question of its validity; but, because of its importance, it should be subjected to critical analysis. The estimate was obtained from a series of assumptions (1) The average prepaid group-practice ratio of about 100 physicians to 100,000 population best reflects the current minimum needs of the nation; although the overall US ratio is higher, in 1967 there were 27 states with a physician per 100,000 population ratio below
John Alexander MacWilliam (1857-1937)
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vector vaccine overcomes anergy
Authors: A. B. Deisseroth, Y. Tang, L. Zhang, H. Akbulut, P.-J. Linton
Journal: Journal of Clinical Oncology (2004)

2579 Background: The development of an immune response to cancer cells is limited by poor delivery of tumor associated antigens (TAA) to dendritic cells (DCs), and the presence on the tumor cells of self antigens to which the immune response system has developed tolerance. We have previously reported that the subcutaneous injection of the Ad-sig-TAA/ecdCD40L adenoviral vector encoding a TAA linked to the extracellular domain (ecd) of the CD40 ligand (CD40L) can overcome the anergy which exists in tumor hosts against TAA. Methods: Our goal in the present work was to characterize the multiple steps that are involved in overcoming the anergy which exists in tumor hosts to TAA. Results: Our present studies showed that the subcutaneous injection of the Ad-sig-TAA/ecdCD40L vector resulted in the secretion of the TAA/ecdCD40L protein for at least 10 days from the infected cells, the binding of the TAA/ecdCD40L protein to DCs, induction of expression of the CCR-7 chemokine receptor and cytokine release, and migration of the activated and antigen loaded DCs from the injection site to the regional lymph nodes. Tetramer staining, ELISPOT assay, and cytotoxicity assays all showed that the subcutaneous injection of the Ad-sig-TAA/ecdCD40L vector increased the levels of the splenic CD8+ T cells which were specific for the two TAA (human MUC1 and HPV E7) tested. Vaccination of mice transgenic for the human MUC1 (hMUC1) antigen with the Ad-sig-hMUC1/ecdCD40L vector suppressed the growth of hMUC1 antigen positive tumor cells in 100% of the test mice which were previously anergic to the hMUC1 antigen. The immune resistance to the TAA positive tumor cells lasted up to a year, was antigen specific, and HLA restricted. The subcutaneous administration of the TAA/ecdCD40L protein without first administering a subcutaneous injection of the Ad-sig-TAA/ecdCD40L vector, did not overcome the anergy that exists to TAA anywhere as well as did the subcutaneous injection of the Ad-sig-TAA/ecdCD40L vector injections Conclusions: These data suggest that the Ad-sig-TAA/ecdCD40L vector subcutaneous injections may be of value in the treatment of the many epithelial malignancies in which TAA like hMUC1 are over expressed. No significant financial relationships to disclose.
A novel dispersin protein in enteroaggregative Escherichia coli
Authors: Jalaluddin Sheikh, John R. Czeczulin, Susan Harrington, Susan Hicks, Ian R. Henderson, Chantal Le Bouguénec, Pierre Gounon, Alan Phillips, James P. Nataro
Journal: Journal of Clinical Investigation (2002)

Enteroaggregative Escherichia coli (EAEC) is a diarrheal pathogen defined by its characteristic aggregative adherence (AA) to HEp-2 cells in culture. We have previously shown that EAEC strains secrete a 10-kDa protein that is immunogenic in a human EAEC challenge model. We report here that this protein is encoded by a gene (called aap) lying immediately upstream of that encoding the AggR transcriptional activator, and that aap is under AggR control. The product of aap has a typical signal sequence and is secreted to the extracellular milieu, where it remains noncovalently attached to the surface of the bacterium. EAEC aap mutants aggregate more intensely than the wild-type parent in a number of assays, forming larger aggregates and fewer individual bacteria. Infection of colonic biopsies with wild-type EAEC strain 042 and its aap mutant revealed more dramatic autoagglutination of the mutant compared with the wild-type parent. Our data suggest that the aap gene product participates in formation of a surface coat that acts to disperse the bacteria, thus partially counteracting aggregation mediated by aggregative adherence fimbriae. We have therefore named the aap gene product “dispersin,” and we propose that it may be representative of a functional class of colonization factors. Since dispersin is expressed in vivo, is highly immunogenic, and is present in most EAEC strains, it holds considerable promise as an EAEC immunogen.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Authors: Ce Liu, Gang Tian, Yanyang Tu, Jianfang Fu, Chuan Lan, Nan Wu, Ryosuke Kamiyama, Masahisa Saikawa, Seiji Kishimoto, Hoichi Kato, Akihiro Sato, Haruhiko Fukuda, Yoshikazu Kagami, Harushi Udagawa, Pengfei Liu, Weichang Chen, Hong Zhu, Bingtuan Liu, Shupin Song, Weidong Shen, Fangjun Wang, Steven Tucker, Baoliang Zhong, Daoyuan Wang
Journal: JNCI Journal of the National Cancer Institute (2009)

The correlation between bone morphogenetic protein-2 (BMP-2) and the prognosis of patients with gliomas has not been reported.This study was carried out to investigate the BMP-2 expression pattern in gliomas, and to evaluate its prognostic relevance.
WORKSHOP: H PYLORI - THE DIAGNOSIS OF HUMAN INFECTION
Authors: H Monath, C Kleanthous, J Lee, T Pappo, R Ermak, S Weltzin, A Moavvedi, R Heppell, A Catto, P Grant
Journal: Gut (1995)

Vaccination is a potentially cost-effective approach to the prevention and treatment of Helicobacter plori-induced chronic disease.Since Helicobacterpylori causes a superficial infection of the gastric epithelium, the principal mediator of effective immunity should be IgA antibody stimulated by mucosal presentation of antigen and secreted into the mucus gel..A strong rationale exists for selection of urease as a vaccine candidate.97% (6/7) (OR-OlS1, Cl:0.02-0.8,p=0.02).Conbn~~: Salivary H.pylon lgG was a falhly sensitive and accurate indicator of gsric H.pyloui colonization with a high positive predictive value in our population.Data, howver, suggst that salivary H.pylcri lgG measurement do not comnpare favourably with seology and do not encourage at present the use of salivary H.pylcri IgG in screening dyspepsia.
The detection of sleep apnea in the awake patient. The 'saw-tooth' sign
Authors: M. H. Sanders
Journal: JAMA (1981)

We studied 21 subjects, 13 of whom had the sleep apnea hypersomnolence syndrome associated with upper airway obstruction during sleep (SAHS-UAO) to determine if "saw-toothing" on the flow-volume loop was significantly associated with the phenomenon of airway occlusion during sleep. A "saw-tooth" pattern was present on the flow-volume loop in 11 of 13 subjects with SAHS-UAO. The presence of saw-toothing correlated with fluttering of tissue that was visualized in the upper airway via the fiberoptic bronchoscope. The specificity of the saw-tooth pattern for SAHS-UAO was 100%. Generalized obesity may indirectly influence the presence of saw-toothing due to deposition of what appeared to be adipose tissue in the pharyngeal walls. Although the number of subjects in this study is small, saw-toothing on the flow-volume loop appears to be an important aid in the diagnosis of SAHS-UAO. (<i>JAMA</i>1981;245:2414-2418)
Antistreptococcal Prophylaxis
Authors: Alvan R. Feinstein
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Dr. Feldman has confused the treatment of disease with prevention. We were investigating the prophylaxis of recurrent rheumatic fever, not the treatment of streptococcal infections or the "exhibition of a therapeutic agent." The oral penicillin regimen (200,000 units once daily) that we tested is one of several programs recommended by the Committee on Prevention of Rheumatic Fever... of the American Heart Association (<i>Circulation</i><b>21</b>:151, 1960). In previous clinical trials with other oral regimens (<i>JAMA</i><b>188</b>:489, 1964), a double daily dose of penicillin had been found no more effective for preventing streptococcal infections than a single dose or than oral sulfadiazine. We thank Dr. Feldman for complimenting our research techniques, and we suggest he direct his quarrel to the committee that recommends these prophylactic agents. The reference to control of the "carrier state" in "streptococcal outbreaks" is irrelevant. We were studying the prevention of rheumatic fever
Relative Risk Regression Analysis of Epidemiologic Data
Authors: Ross L. Prentice
Journal: Environmental Health Perspectives (1985)

Relative risk regression methods are described. These methods provide a unified approach to a range of data analysis problems in environmental risk assessment and in the study of disease risk factors more generally. Relative risk regression methods are most readily viewed as an outgrowth of Cox's regression and life model. They can also be viewed as a regression generalization of more classical epidemiologic procedures, such as that due to Mantel and Haenszel. In the context of an epidemiologic cohort study, relative risk regression methods extend conventional survival data methods and binary response (e.g., logistic) regression models by taking explicit account of the time to disease occurrence while allowing arbitrary baseline disease rates, general censorship, and time-varying risk factors. This latter feature is particularly relevant to many environmental risk assessment problems wherein one wishes to relate disease rates at a particular point in time to aspects of a preceding risk factor history. Relative risk regression methods also adapt readily to time-matched case-control studies and to certain less standard designs. The uses of relative risk regression methods are illustrated and the state of development of these procedures is discussed. It is argued that asymptotic partial likelihood estimation techniques are now well developed in the important special case in which the disease rates of interest have interpretations as counting process intensity functions. Estimation of relative risks processes corresponding to disease rates falling outside this class has, however, received limited attention. The general area of relative risk regression model criticism has, as yet, not been thoroughly studied, though a number of statistical groups are studying such features as tests of fit, residuals, diagnostics and graphical procedures. Most such studies have been restricted to exponential form relative risks as have simulation studies of relative risk estimation procedures with moderate numbers of disease events.
From the Centers for Disease Control. Progress toward eradicating poliomyelitis from the Americas
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Landmark article May 18, 1929: The use of a new apparatus for the prolonged administration of artificial respiration. I. A fatal case of poliomyelitis. By Philip Drinker and Charles F. McKhann
Authors: P. Drinker
Journal: JAMA (1986)

A number of patients have come under our observation who have shown intercostal paralysis and considerable weakness of the diaphragm early in the paralytic stage of anterior poliomyelitis; yet the accessory muscles and the diaphragm have been able to support sufficient respiratory movement to keep the patient alive until, in the course of a few days, the paralyzed intercostal muscles began to improve and the patient went on to almost complete recovery. Although this is not the usual termination of these cases, it occurs often enough to stimulate the desire to give all patients with respiratory paralysis this opportunity to recover normal breathing by maintaining artificial respiration over a period of hours, or even days. <h3>LIMITATIONS OF PRESENT METHODS OF PROLONGING LIFE</h3> The means of prolonging life in these patients are limited to the available methods of applying artificial respiration. Of these, the manual methods are not adapted to prolonged
Pelvic versus cortical tumors
Authors: C. V. Hodges
Journal: JAMA (1968)

The renal pelvis arises from the ureteric bud (mesonephric duct), whereas renal parenchyma develops from the nephrogenic cap. This difference in derivation may account, at least in part, for the marked difference in behavior of tumors arising in the two sites. Tumors of the renal pelvis develop from transitional cell epithelium and vary from relatively benign papillomas to highly malignant, infiltrating, sessile tumors. Squamous cell carcinoma may develop as further metaplasia of transitional cell carcinoma occurs, or separately, as the result of reaction to long-continued irritation. A very rare type of pelvic tumor is the mucoid adenocarcinoma. <h3>Etiology</h3> The transitional epithelium of the renal pelvis shares the property of its counterpart, throughout the urinary collecting system, in its response to carcinogenic agents excreted in the urine, to irritation, or most often, to unknown agents. Although still relatively uncommon, it is believed by recent authors<sup>46</sup>that the incidence is rising.
PROTECTING THE FOOL FROM HIS FOLLY.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
William Osler, 1849-1919. Commemorative issue
Authors: C. G. Roland
Journal: JAMA (1969)

On Dec 29, 1919, six months past his 70th birthday, Sir William Osler died; at his death he was unquestionably the most loved and perhaps also one of the most influential physicians in history. A brief biographical essay appears on page 2269. His full biography, written by Harvey Cushing, is highly recommended to every physician, and especially to medical students, to help offset any current lack of instruction in medical humanism. Two years ago, with the permission and encouragement of the editor ofThe Journal, I began to plan a commemoration of the 50th anniversary of Sir William Osler's death. The contributors to this tribute include a distinguished group of former pupils of Osler: Wilder Penfield, Watson Rankin, Emile Holman, Wilburt Davison, J. B. Langstaff, Patrick Mallam, and A. G. Gardner all knew him, and loved him, and treasure their memories of him— memories that they share here with those
Descriptive Error in the Text
Authors: Joslyn Kirby
Journal: JAMA Dermatology (2017)

Matthew D. Truesdale, MD; E. Charles Osterberg, MD; Thomas W. Gaither, BS; Mohannad A. Awad, MD; Molly A. Elmer-DeWitt, MD; Siobhan Sutcliffe, PhD; Isabel Allen, PhD; Benjamin N. Breyer, MD, MAS
Haematology in General Practice.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal