tbuckley/cabot-search huggingface dataset:
Abstract 3296: SRC-3 is a critical mediator in the development of castration-resistant prostate cancer
Authors: Jean C. Tien, Zhaoliang Liu, Li Gao, Fen Wang, Jianming Xu
Journal: Cancer Research (2012)

Abstract Androgen ablation therapy is the standard treatment for advanced prostate cancer. While tumors initially respond to androgen deprivation, they almost always recur with an androgen-independent phenotype termed castration-resistant prostate cancer (CRPC). Castration-resistant tumors are incurable with current therapy regimens and account for most prostate cancer mortality. Better understanding of their biology is therefore critical for devising novel treatment options. Steroid Receptor Coactivator 3 (SRC-3) is a nuclear receptor coactivator that promotes growth of endocrine tissues. It enhances proliferation of prostate cancer cell lines and is highly expressed in advanced human prostate tumors. Despite this, the role of SRC-3 in CRPC is not well studied. PTEN is a tumor suppressor gene mutated in most human prostate cancers. Mice harboring PTEN deletion in prostatic epithelial cells develop cancer that arises from progenitors in the luminal epithelial and basal compartments. Tumors histologically mimic advanced human disease and are castration-resistant. We hypothesized that, in prostate tumors caused by PTEN deletion, SRC-3 is a critical mediator for accelerating the development of CRPC. To test this hypothesis, we generated mice in which floxed PTEN and SRC-3 genes were concomitantly deleted in prostate epithelial cells via a Cre recombinase driven by the Probasin promoter. We first compared tumor mass, histology and biomarkers in these PTENf/f/SRC-3f/f/ARR2PBiCre (pten3cko) mice vs. PTENf/f/ARR2PBiCre (ptencko) mice. We found that while tumor growth in pten3cko mice was slightly inhibited at 9 wks of age, tumor histology and cellular composition were not markedly different. We then castrated mice of both genotypes at 9-wks-old and harvested tumors at 12wks. Interestingly, castrated ptencko mice had significantly worsened tumor aggressiveness–as indicated by increased proliferation index, reduced differentiation (increased p63; decreased K5 and K8) and increased reactive stroma (double staining of SMA and vimentin)–versus their non-castrated counterparts. Amazingly, in addition to significantly reducing tumor size, SRC-3 ablation reversed all changes comprising the aggressive phenotype seen in the post-castration tumors. Further investigation showed SRC-3 deletion decreased mTOR signaling. Together, these data show that castration induces a worse tumor phenotype in the setting of PTEN deletion and that SRC-3 promotes this process by inducing epithelial cell proliferation and enhancing the growth-promoting effect of these cells on the stroma. Therefore, SRC-3 may serve as a potential target for controlling CRPC development. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3296. doi:1538-7445.AM2012-3296
Attention-deficit disorder. Born to be hyperactive?
Authors: A. J. Zametkin
Journal: JAMA (1995)

<h3>SELECTED CASES</h3><h3>Patient 1</h3> An 8-year-old boy was evaluated in the National Institutes of Health outpatient clinic in Bethesda, Md, for participation in research. The patient history was positive for 12 of the 14 criteria of attention-deficit hyperactivity disorder (ADHD) listed in the<i>Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-III-R</i>)<sup>1</sup>(Table 1). Symptoms displayed by this patient included major disability due to poor attention span, impulsivity, distractibility, increased motor activity, and poor social skills. A structured psychiatric interview with his parents revealed no other causes of these symptoms by excluding the possibility of anxiety disorder or mood disorder, among others. (See Table 2 for differential diagnosis.) The physical examination yielded normal findings, and an evaluation of mental status revealed restlessness and poor impulse control characterized by the patient's repeated interruptions of the interviewer. A laboratory examination and psychometric testing indicated no learning disability but revealed
Acute hemorrhagic cystitis. Industrial exposure to the pesticide chlordimeform
Authors: D. S. Folland
Journal: JAMA (1978)

An outbreak of hematuria occurred from May 20 to May 23,1975, among employees of a chemical packaging plant. Nine of 22 workers who packaged the insecticide chlordimeform in a separate shed became severely ill with abdominal pain, dysuria, urgency to void, or hematuria. None of 18 persons who worked in other areas of the plant were affected. Four additional workers who had packaged the chemical during the previous year had a history of similar symptoms. Bladder biopsy specimens from three affected persons showed severe hemorrhagic cystitis; chlordimeform and 2-methyl-4-chloroaniline, a metabolite of chlordimeform, were present in urine specimens collected three days after exposure. The illness lasted from one week to two months; the workers recovered completely. Chlordimeform that was injected subcutaneously into three cats produced similar, though less severe, changes in the bladders of two animals. (<i>JAMA</i>239:1052-1055, 1978)
Pro-free enterprise group challenges FDA's authority to regulate drug companies' speech
Authors: A. A. Skolnick
Journal: JAMA (1994)

THE US Food and Drug Administration (FDA) has indefinitely postponed the publication of its long-awaited final policy statement on industry-supported scientific and educational activities. The FDA has delayed issuing its final guidelines—which were supposed to be published by the end of 1993—in order to answer a "civil petition" filed by a "pro—free enterprise" group that is challenging the agency's legal authority to regulate the speech of pharmaceutical and medical device manufacturers. The Washington, DC—based group, called the Washington Legal Foundation, is asking the FDA to cease "violating the First Amendment rights" of physicians and patients who have an urgent need for timely information about these products. The foundation's petition, filed on October 22, asks the FDA "to withdraw its draft policy ["Draft Policy on Industry-Supported Scientific and Educational Activities,"<i>Federal Register</i>. November 27,1992] and to refrain from taking any enforcement action against manufacturers that sponsor scientific or educational activities or
CAPTAIN: Effects of Cardiovascular Risk on Response to Triple Therapy in Patients With Inadequately Controlled Asthma on Inhaled Corticosteroids/Long-acting β2-agonists (ICS/LABA)
Authors: Nicola Hanania, Zelie Bailes, Sarah Chang, Andrew Fowler, Robson Lima, David Mannino, Mark Millard, Joseph Spahn, Steve Weinstein, Robert Nathan
Journal: Journal of Allergy and Clinical Immunology (2021)
Utilization and outcomes of surgical castration in comparison to medical castration in metastatic prostate cancer.
Authors: Rohan Garje, Adithya Chennamadhavuni, Sarah L Mott, Isaac Matthew Chambers, Paul Gellhaus, Yousef Zakharia, James A. Brown
Journal: Journal of Clinical Oncology (2019)

288 Background: Androgen deprivation therapy (ADT) is the gold standard for metastatic prostate cancer (mPC) which can be achieved either by surgical or medical castration (SC, MC). In this study we evaluate the trends of utilization of SC and also assess survival difference compared to MC. Methods: National Cancer Database was used to identify patients with mPC from 2004 to 2014. Logistic and Cox regression models were utilized to estimate the odds of utilization of SC and effect of treatment on overall survival (OS). Results: A total of 33712 pts with mPC were identified; 31722 (94.1%) had MC and 1990 (5.9%) underwent SC. There was significant decline in the trend of utilization of SC from 8.5% in 2004 to 3.1% in 2014. On multivariable analysis, being a non-caucasian race, lower household income levels, having non-private insurance and earlier years of Dx were found to be associated with increased odds of choosing SC over MC. Notably, the odds of SC were lower at academic centers. On univariate analysis, a survival difference between ADTs was evidenced (p&lt;0.01); 5-yr OS for MC and SC was 24.8% and 18.2%. However, on multivariate analysis there was no OS difference between SC and MC (p=0.14). Conclusions: In this large contemporary analysis, the utilization of SC has declined overtime with no OS difference when compared to MC. With rising health care costs, changing the practice by utilizing SC can help reduce healthcare expenditure. [Table: see text]
WAS IT A DECOY OR SILLY "CATCH," OR A REAL ATTEMPT TO GAIN POSSESSION OF A DIPLOMA, IN DUE FORM, UNDER THE PRETENSE OF HAVING IT CONFERRED UPON A "FRIEND?"
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4567: Functional characterization of P58IPK-PERK pathway in prostate cancer cells
Authors: Xia Sheng, Margrethe Storm, Yang Jin, Fahri Saatcioglu
Journal: Cancer Research (2016)

Abstract Androgen signaling is important for the normal development and function of the prostate as well as for prostate cancer (PCa). We recently found that androgens activated the IRE1α-XBP1 arm of the canonical unfolded protein response (UPR) pathways and simultaneously inhibited PERK-eIF2α signaling. Activation of the IRE1α-XBP1 arm was mediated by direct binding of the androgen receptor (AR) in the vicinity of IRE1, as well as XBP1s target genes, and increase in their expression. Consistently, AR and IRE1α pathway gene expression are correlated in human PCa samples and XBP1s protein expression is significantly increased in cancer compared to normal prostate. However, the mechanisms behind androgen mediated inhibition of PERK-eIF2α signaling are not clear at present. One possible mediator in this regard is P58IPK, an XBP1s target gene that can interact with and inhibit PERK and eIF2α phosphorylation. Here, we show that P58IPK expression is increased by androgens in a time-dependent manner and that it plays a pro-survival role in PCa cells. P58IPK knockdown activated PERK expression as well as subsequent eIF2α phosphorylation when induced with the UPR activator thapsigargin. These findings suggest that P58IPK mediates, at least in part, the differential androgen effects between the IRE1α and PERK signaling in PCa and may be a potential therapeutic target. Citation Format: Xia Sheng, Margrethe Storm, Yang Jin, Fahri Saatcioglu. Functional characterization of P58IPK-PERK pathway in prostate cancer cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4567.
Effects of S-adenosyl-?-methionine on hepatic and renal oxidative stress in an experimental model of acute biliary obstruction in rats
Authors: J Gonzalez-Correa
Journal: Hepatology (1997)

We used an animal model of extrahepatic biliary obstruction of 7 days' duration to study the production of thiobarbituric acid reactive substances (TBARS), total glutathione (TG), reduced glutathione (GSH), and oxidized glutathione (GSSG), and the enzymatic activities of GSH- peroxidase, GSSG-reductase, and GSH-transferase. Four groups of six rats each were treated with saline, drug solvent, S-adenosyl-l-methionine (SAM) 5 mg/kg/d, subcutaneously, or SAM 10 mg/kg/d, subcutaneously. Extrahepatic biliary obstruction increased TBARS. SAM had the dose-dependent effects of inhibiting TBARS production and increasing TG content, mainly as a result of the increase in GSH. The activity of GSH-peroxidase and GSH-transferase was also significantly increased. In renal tissue these effects were statistically significant only in animals given the higher dose of SAM. In liver we found a reduction in biochemical values indicative of liver damage. We conclude that effect of SAM on hepatorenal function is strongly influenced by the drug's ability to reestablish equilibrium after oxidative tissue stress. (Hepatology 1997 Jul;26(1):121-7)
Chromoendoscopy
Authors: Mario Dinis Ribeiro, José Soares
Journal: Endoscopy (2009)

This text was the result of consensus meeting in April 2007, in Porto, Portugal, organized by the Sociedade Portuguesa de Endoscopia Digestiva (SPED). For each GI segment (Esophagus, stomach and colon) questions concerning validity and adequacy of the different type of studies assessing the use of chromoendoscopy and magnification chromoendoscopy were answered by the following panel: José Soares e Mário Dinis Ribeiro (SPED); Nuno Mesquita, Pedro Amaro, Miguel Areia, Paulo Fidalgo, António Dias Pereira e Susana Mão de Ferro, Paulo Ratilal, Pedro Pereira, João Carvalho, Luisa Proença e Ana Paula, Marta Salgado, Luís Lobo e Miguel Mascarenhas, José Cotter, Ricardo Freire, Luĩs Filipe Azevedo; António Curado, António Marques. No disclosure was made by any of the participants.
Serine 559 Of Glycoprotein Ibα Is Phosphorylated By Protein Kinase A Which Plays Key Roles In Regulating Von Willebrand Factor Binding, Surface Expression, and Signaling Of Glycoprotein Ib-IX
Authors: Jie Zhang, Weilin Zhang, Guanglei Liu, Lili Zhao, Rong Yan, Kesheng Dai
Journal: Blood (2013)
Amer J of Roentgenology, Springfield, Ill
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Simple Method for Intracardiac Acoustic Ausculation and Phonocardiography
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Healers
Authors: Mike Oppenheim
Journal: New England Journal of Medicine (1980)

The role of the American physician has changed over the past generation. The doctor seems to be taking responsibility for everyone all the time. People expect medical attention even when they feel fine. The profession is debating about how much time and energy it should devote to well-patient care. There is much less debate over whether doctors should perform such activities at all.In the category of "well-patient care" I include such concepts as health "maintenance," "preventive" medicine, and the annual physical. Behind them is the belief that a well person can harbor a multitude of hidden diseases and harmful . . .
Recommendations for Preventing TB Transmission
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Puerperale Wundinfektion.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suppression of Endogenous TSH: A New Treatment of Subacute Thyroiditis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shock
Authors: Mara Feingold-Link
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal