tbuckley/cabot-search huggingface dataset:
The Sensitive Heart
Authors: Richard O. Cannon
Journal: JAMA (1995)

<h3>SELECTED CASE</h3> A 50-year-old woman was referred to the National Institutes of Health because of a 12-year history of anginalike chest pain despite normal coronary angiograms. She described her symptom as a substernal pressure sensation radiating to the left shoulder and arm, provoked by effort and relieved by rest. Two years prior to admission, she underwent cardiovascular evaluation that included treadmill exercise testing associated with ischemic-appearing electrocardiogram (ECG) changes. Beta-blocker therapy (120 mg of nadolol daily) diminished symptoms somewhat, but because of continued effort-provoked chest pain, she underwent cardiac catheterization, which demonstrated normal-appearing coronary arteries and left ventricle. Nadolol was discontinued, and she was started on 90 mg of diltiazem hydrochloride twice daily, which did not relieve her symptoms. She did find sublingual nitroglycerin to be of help in relieving pain. Her past medical history is significant for a cholecystectomy 3 years prior to admission and cigarette smoking discontinued 10
American Cancer Society Second National Conference on Cancer Prevention and Detection
Journal: JNCI Journal of the National Cancer Institute (1987)

American Cancer Society Second National Conference on Cancer Prevention and Detection Get access JNCI: Journal of the National Cancer Institute, Volume 78, Issue 3, March 1987, Pages 593–594, https://doi.org/10.1093/jnci/78.3.593-c Published: 01 March 1987
The Relation of Virologic and Immunologic Markers to Clinical Outcomes after Nucleoside Therapy in HIV-Infected Adults with 200 to 500 CD4 Cells per Cubic Millimeter
Journal: New England Journal of Medicine (1997)

Correction from The New England Journal of Medicine — The Relation of Virologic and Immunologic Markers to Clinical Outcomes after Nucleoside Therapy in HIV-Infected Adults with 200 to 500 CD4 Cells per Cubic Millimeter
Radioimmunotherapy with Yttrium-90-Ibritumomab Tiuxetan as Part of a Reduced Intensity Conditioning Regimen for Allogeneic Hematopoietic Cell Transplantation in Patients with Advanced Indolent Non-Hodgkin Lymphoma: Interim Analysis of a Phase II Study.
Authors: Wolfgang A Bethge, Thoralf Lange, Stephanie von Harsdorf, Martin Bornhauser, Birgit Federmann, Michael Stadler, Lutz Uharek, Stefan Knop, Gerald Wulf, Helmut Dittmann, Christoph Faul, Wichard Vogel, Lothar Kanz, Donald Bunjes
Journal: Blood (2008)
A System of Medicine.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aspiration or exploration to confirm diagnoses of renal masses
Authors: C. J. Devine
Journal: JAMA (1968)

Though some renal cysts require surgical treatment, recent improvements in diagnostic methods for differentiation of benign cysts from solid tumors have made it unnecessary to assume the risk associated with exploration of the kidney each time a mass is discovered. There remains, however, a percentage of error in the evaluation of these studies. Confirmation of the diagnosis should be obtained by aspiration in the case of cysts and by surgical exploration and treatment of tumors. We have employed a system for the evaluation of renal masses with the use of various radiological techniques. Whenever in the course of this investigation a diagnosis of cyst or tumor was made, the appropriate confirmatory procedure was carried out. If the diagnosis was still indefinite when all the tests had been done, exploration was also indicated.
Correction
Journal: Annals of the Rheumatic Diseases (2013)

In panel A of figure 3 there are three histological images.The image on the left is from AdLacZ control mouse treated with a non-targeting siRNA, while the image on the right is from a genetically modified AdTBR mouse treated with siRNA against ubc9.However, the two histological pictures are identical to each other.The correct image of AdLacZ control mice treated with non-targeting siRNA is shown below.
Aspects of Database Construction and Interrogation of Relevance to the Accurate Prediction of Rodent Carcinogenicity and Mutagenicity
Authors: J. Ashby
Journal: Environmental Health Perspectives (1991)

Attempts to reconcile qualitative carcinogenicity databases with qualitative mutagenicity database continue to indicate that there is no useful relationship between mutagenicity/genotoxicity and rodent carcinogenicity. It is suggested that recognition of two classes of carcinogen, genotoxic and nongenotoxic, is the first step in finding meaningful correlations between the above parameters. This then leads to purposeful intervention into the databases, including rejecting low quality data, abandoning some assays from the database, and clustering certain end points as repetitive rather that independent of each other. Seeking specific correlations within a focused database may yield knowledge from the current wealth of information. The effort required to build databases, particularly quantitative ones, has so far prevented the equally arduous task of their correct interrogation. Preliminary indications are the mutagenicity is closely correlated with genotoxic carcinogenesis and completely independent of nongenotoxic carcinogenesis.
Abstracts
Journal: Annals of the Rheumatic Diseases (1962)

The anaemia of the early stages of acute rheumatic fever has been variously ascribed to depressed erythro- poiesis, haemolysis, or dilution of erythrocytes by increased plasma volume.The author of this paper from the University of Cincinnati, Ohio, has re-investigated this problem in eight apparently well children and in ten with rheumatic fever without congestive heart failure, using the dye dilution method (T-1824) for plasma volume and the radioactive chromium technique for erythrocyte volume.Only one of the ten patients had had salicylate therapy for more than 3 days and three had had none; symptoms had lasted more than 10 days in three patients only.The plasma volume was significantly increased in the patients compared with the controls (mean 59 ml. per kg.body weight compared with 45 ml. per kg.), the values being above the highest control reading in five of the ten patients.A repeat estimation in seven patients 10 to 80 days after the first showed a substantial decrease in plasma volume.There was no difference between three patients and five healthy controls in the rate of disappearance of dye in the first 30 minutes after injection, ruling out increased permeability or leakage.The half- life of erythrocytes in three patients ranged from 25 to 32 days, and no reticulocytosis was seen.In three patients there was good agreement between the results of the two methods of estimating blood volume.It is concluded that the decreased haematocrit value in the early stage of rheumatic fever is due usually to dilution of the erythrocyte mass by an increased plasma volume.
Medical Greats
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents page + Editorial Board + Cover figure legend
Authors: Andrew Clark, Katja Brose, Olaf Meesters, Ria Otten, Patrick Scheffmann, Silvia Arber, Anders Björklund, Sweden Lund, Sarah Paul Bolam, Barry Dickson, Chris Doe, Craig Garner, Yukiko Goda, Kenneth Harris, Nancy Ip, Maria Karayiorgou, Robert Malenka, Mark Mattson, Freda Miller, Canada Richard, G Morris, Maiken Nedergaard, Eric Nestler, New York, Hitoshi Sakano, Greg Stuart, Marc Tessier-Lavigne, Chris Walsh
Journal: Trends in Neurosciences (2014)
Abstract 14288: Implementation of a Multidimensional Bundle for Dispatcher Telephone CPR in a Horizontal Dispatch System is Associated With Increased Bystander CPR and Good Neurological Survival From Out-of-Hospital Cardiac Arrest
Authors: Sot Shih-Hung Liu, Kah-Meng Chong, Hui-Chih Wang, Yu-Wen Chen, Chih-Ming Hsu, Chung-Rong Tseng, Chao-Lun Hung, Chien-Hua Huang, Hung-Sung Lin, Yun-Chung Yang, Mei-Fen Yang, Chih-Wei Yang, Yueh-Ping Liu, Matthew Huei-Ming Ma, Patrick Chow-In KO
Journal: Circulation (2015)

Background: The resuscitation guidelines indicate pre-arrival dispatcher-assisted telephone CPR (DATCPR) instructions and measurement to increase the proportion of bystander CPR (BCPR), however the impact of those guidelines on survival is not well known. Objective: To describe the impact of a comprehensive bundle of DATCPR on BCPR and survival from OHCA in a horizontal computerized-aided dispatch (CAD) system. Methods: A centralize CAD system in a metropolitan EMS is studied. Routinely in system the time from call to ambulance dispatch should be within 60 seconds. The audio recordings of confirmed OHCAs were reviewed using a standardized format linked with EMS and hospital process and outcome data. The proportions of BCPR and survival six months after implementation (P1) of a bundle that included guideline-based protocol changes, staff training, computerized audit, feedback to providers and leadership rebuilt are compared with that of the same month period in the prior year as control group (P0), using regression analysis for statistics. Results: There were 1437 OHCAs [665 P0, 772 P1; 64% male, median age 62 (IQR: 47-74)](Table 1). The rate of BCPR went from 20.6% in P0 to 35.0% in P1 (p&lt;0.001). Outcome of ROSC (return to spontaneous circulation) upon hospital arrival was significantly higher in P1 (10.4%) compared to P0 (6.6% p=0.037), as was good neurological outcome (CPC 1or2: 5.5% in P1 vs. 2.6% in P0 p=0.029). Survival to hospital discharge was higher in P1 (8.3%, vs. P0: 6.4%) but not statistically significant. After adjusting for witnessed arrest, shockable rhythms, age, sex, and pre-hospital time intervals, good neurological outcome were still significantly higher in P1 vs. P0 [adjusted odds ratios: 2.1 (95% 1.1-4.4)]. Conclusions: The implementation of a comprehensive bundle of DATCPR in a metropolitan horizontal dispatch system was associated with significant improvements in the rates of BCPR and good neurologic outcome after OHCA.
An Address Delivered at the Opening of the Section of Ophthalmology
Authors: D. C. L. Owen
Journal: BMJ (1890)

tended over a very limited period, and afforded a quite inadequate basis of comparison.I have, therefore, limited myself to a very careful examination of the results of treatment in B&rnwood House from its commencement just thirty years ago.So far as they go, the figures may be relied upon.P&tients have through- out been received in the order of their application, without special selection.Epileptics and general paralytics have not been de- clined.There has been no limit of age, and no restriction of a physical or mental character.The same conditions have been maintained throughout the period, and all the paiients bave been drawn from the upper and middle classes.There has, therefore, been a small percentage of epileptics, and only a moderate propor- tion of general paralytics, while aged persons have not been crowded in to save the expense and trouble of home nursing.The records show the following results in quinquennial
Apologia
Authors: N. T. Pollitt
Journal: JAMA (1967)

<h3>To the Editor:—</h3> My misquotation of Dr. Goldsmith's letter was a typing slip and quite innocent; I apologize. However, I hope this did not detract from the point I wanted to make, which is that there are clear-cut clinical indications for the intravenous administration of B vitamins.
Current Neurology
Authors: Louis D. Boshes
Journal: JAMA (1980)

This volume is a revised and updated edition of a previous tome, incorporating many new advances in the neurosciences. In just over 500 pages, the authors delineate their contributions: 26 topics arranged in 11 carefully selected major sections. Each of the 36 authorities is a person of established reputation in his or her particular field of interest. Subjects range from basic neurosciences to higher cortical function, with coverage of the most controversial areas, making this a very up-to-date work. The contributors are open-minded as they discuss their own thinking and the thinking of others. Each section, in my judgment, is masterfully written, surpassing even the brilliance of the earlier volume. Reviews of past and recent research and clinical correlations put new progress into a broad context. Topics are smoothly developed, and the text reads easily. All references are clear, abundant, and recent, and the reader will have no problems locating
Physician Manpower
Authors: Joseph F. Pofit
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Health systems agencies, by legislative mandate, must evaluate resource availability in their respective service areas. One resource category that should be evaluated is manpower, particularly the availability of primary care physicians. Existing need assessment methodologies that many federal agencies use (eg, physician to population ratios) have serious conceptual defects. When a sample of practitioners is used for planning purposes without the inclusion of other qualifying measures, inaccuracies can lead to underestimates in federal funding allocations, usually to the detriment of local communities. Before public dollars are committed and planning projects initiated, agencies must reassess their physician inventories, adjust manpower-to-population ratios, and develop valid and more consistent methodologies for determining the need for primary care physicians. Holden and Levit's recent article on physician specialty changes (239:205, 1978) begins to address some of the problems in manpower planning. This study, however, omits two other concerns that are essential for
Therapeutisches Taschenbuch für Ärzte und Studierende
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Cadmium on Nuclear Protein Kinase C
Authors: Detmar Beyersmann, Christoph Block, Anant N. Malviya
Journal: Environmental Health Perspectives (1994)

Cadmium is a carcinogen whose genotoxicity is only weak.Besides its tumor-initiating capacity, cadmium may be tumor-promoting, since it inter- feres with several steps of cellular signal transduction.We have investigated effects of cadmium(ll) on protein kinase C (PKC), which is a key enzyme in the control of cellular growth and differentiation.Tumor-promoting phorbol esters cause an activation and translocation of PKC from the cytosol to the plasma membrane and to the nucleus of mammalian cells.In mouse 3T3/10 T 1/2 fibroblasts, cadmium(ll) potentiated the effect of phorbol ester on nuclear binding and activation of PKC.Furthermore, in a reconstituted system consisting of rat liver nuclei and rat brain PKC, cad- mium stimulated the binding of the enzyme to a 105-kDa protein.We propose a model in which cadmium(ll) substitutes for zinc(ll) in the regulatory domain of PKC, thus rendering the putative protein-protein binding site exposed.Further work is required to elucidate the potential role of the nuclear PKC binding protein(s) in the control of cell proliferation.-
THE CHOLERA.
Journal: JAMA (1905)

From the press dispatches we learn that Asiatic cholera has again invaded Western Europe from Russia, where it has probably been more or less epidemic for some time, notwithstanding the alleged statement of an official commission that no case has occurred in the Russian empire since April 21. The cases thus far reported are confined to certain districts of Prussia, one or two exceptional cases occurring in Hamburg. While it is not anticipated that there will be any repetition of the epidemic of thirteen years ago, the sanitary authorities are wide awake to a certain degree of peril in the situation, and even in this country steps have been taken by the Public Health and Marine-Hospital Service to prevent any possible importations of the disease. The sanitary conditions in Russia are never entirely satisfactory, and it was pointed out some time since that, owing to the internal disturbances and to
Ultra long-term prognosis of vasospastic angina with normal coronary arteriogram treated by calcium channel antagonists: Results from twenty-year prospective follow-up study Kenichi Ito, Masakazu Yamagishi, Hiroshi Tsutsui, Kazuo Haze, Tetsuya Sumiyoshi, Kenichi Fukami. National Cardiovascular Center, Suita, Japan
Journal: Journal of the American College of Cardiology (2001)
Insect Vectors of Disease
Authors: Vlado A. Getting
Journal: New England Journal of Medicine (1945)

Conenose BugsThe conenose bugs belong to the order Hemiptera, family Reduviidae.91 They are commonly called "assassin bugs," "kissing bugs," "corsairs," "black corsairs," "wheel bugs" and "bedbug hunters." Predatory in nature, several species protect themselves by biting, whereas others have developed a distinct habit of sucking mammalian blood. Two genera, Triatoma and Rhodius, contain conenose bugs of medical interest. Although a few species are worldwide in distribution, the majority are found in the Western Hemisphere, particularly in the high cold regions of the Andes.Most conenose bugs are active runners and good fliers. Since white man's invasion of South America, . . .
MEDICAL EDUCATION.
Authors: HENRY M. LYMAN
Journal: JAMA (1893)

The present is a time of evolution and change in the methods of medical education. The country has outgrown the old system which was the best that could be provided for the hungry boys who could hardly keep soul and body together during a term of sixteen weeks of exclusion from the maternal pantry. Thus far the progress that has been made is in the way of real improvement. It might have been much more rapidly effected had the pecuniary endowments of medical education been established upon broader foundation; but, taking everything into consideration, the teachers of medicine throughout the country have accomplished all that with their limited resources was possible. We have reached the point where eight or nine months'sessions are required at the leading medical schools, and four years of study are requisite for graduation. The next step in advance will consist in the enforcement of attendance upon
Landmark article Sept 8, 1945: Cyanosis in infants caused by nitrates in well-water. By Hunter H. Comly
Authors: H. H. Comly
Journal: JAMA (1987)

Two examples of a previously unrecognized condition which may be confused with congenital heart disease are cited in this report. The condition may occur anywhere in rural areas where well water is used in infant feeding. <h3>REPORT OF CASES</h3><h3>Case 1.—</h3> C. H., a white female baby, was born two weeks before the expected date by cesarean section because of toxemia of pregnancy, which had been severe for one month. The birth weight was 3,870 Gm. (8 pounds 8 ounces). There was no known neonatal distress. On the twelfth day after birth, when she left the hospital, she weighed 3,720 grams (8 pounds 3 ounces). The formula she was receiving at that time was evaporated milk 210 cc. and water 540 cc. with 30 Gm. of a dextrin-maltose preparation. She was admitted to a local hospital at 18 days of age because of vomiting, excessive crying and failure to gain
Images
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal