tbuckley/cabot-search huggingface dataset:
Reply
Authors: D Hollander, A Tarnawski
Journal: Gut (1986)

which provided additional substrate for PGE2 synthesis would also provide additional substrate for the synthesis of prostacyclin, thromboxane, and the leukotrienes.The authors provide no indication as to the effect of increased linoleate intake on the balance of eicosanoids, or of the effects of changes in this balance on the course of peptic ulcer disease.The proposed hypothesis relies heavily on the epidemiological evidence linking the decline in peptic ulcer disease with the rise in essential fatty acid intake.Their data shows that between 1909/ 1913 and 1980, there has been a 300% increase in the intake of linoleic acid while during the same period the intake of saturated fatty acids has increased by only 10%.Does this mean that the rise in the incidence of coronary heart disease is not after all associated with a rise in the intake of saturated fats but with a rise in the intake of the polyunsaturated essential fatty acids?This dubious epidemiological evidence must be supported by other data for tentative acceptance of this hypothesis.One would need to know whether what is reportedly seen for the USA as a whole, is also evident with different age-groups, different regions of the USA, for men and women, etc. Equally one would require interna- tional comparisons of diet and peptic ulcer disease.Science proceeds through the integrated processes of conjecture and refutation.In proposing a hypothesis, vagueness should be avoided and precision encouraged.Just as there are rules in refutation there are rules in conjecture, otherwise we may just as well take up astrology.
Tubulointerstitial and glomerular nephritis associated with rifampin. Report of a case
Authors: P. A. Gabow
Journal: JAMA (1976)

In a patient with tuberculosis and acute renal failure related to administration of therapeutic rifampin, treatment was discontinued for five weeks. It was reinstituted three weeks later. Unlike other patients previously described, the expected adverse renal reaction occurred only gradually and without symptoms, although tubular and glomerular disease developed. Also unique was a striking deposition of immunoglobulin about the tubules. This finding, in association with interstitial nephritis and tubular glycosuria, is similar to an experimental autologous renal disease mediated by antibody to tubular basement membrane. (<i>JAMA</i>235:2517-2518, 1976)
Abstract 3464: Differential Effects of Progenitor Cell Populations on Myocardial Neovascularization and Left Ventricular Remodeling after Myocardial Infarction
Authors: Christophe L Dubois, Xiashun Liu, Glenn Marsboom, Helène Depelteau, Peter Pokreisz, Witold Streb, Lertlak Chaothawee, Frederik Maes, Hilde Gillijns, Marijke Pellens, Desire Collen, Thierry VandenDriessche, Marinee Chua, Frans Van de Werf, Jan Bogaert, Stefan Janssens
Journal: Circulation (2008)

Background: Cardiac progenitor cell transfer may improve myocardial repair after acute myocardial infarction (AMI), but responsible cell types and mechanisms remain uncertain. Methods: In a blinded, randomized, controlled study, we infused allogeneic porcine LentiGFP-infected mesenchymal stem cells (MSC, n=11, 10±2x10 6 CD29 – 44 –90 cells, capable of adipogenic and osteogenic differentiation), autologous late-outgrowth endothelial progenitor cells (EPC, n=10, 34±22x10 6 CD29 –31 cells, capable of tube formation) or vehicle (CON, n=10) in the CX artery 1 w after AMI induced by 90 min balloon occlusion. Hemodynamic and cine MRI measurements (dP/dt max/min and ejection fraction, EF) were performed at 1w and 7w follow-up. We measured LV remodeling from end-diastolic and end-systolic volumes (EDV, ESV) and quantified infarct size and transmurality on late enhanced images. We evaluated the secretome of cultured EPC and MSC and compared changes in relative upslope (RU) of first-pass perfusion images and vascular density on postmortem sections from infarct core and border zones. Results: While systolic function (dP/dt max/min and EF) at 7 w was similar between groups, LVEDV increased in MSC and CON pigs, but not in EPC pigs [+23.3 (25–75 th percentile 1.7;27.9) and +26 ml/m 2 (17.9;31.9) vs +0.8 ml/m 2 (−10.1;18.8), resp, P &lt;0.05]. A similar trend was noted for LVESV [+11.1 (10.4;15.4) and +10.7 ml/m 2 (5.9;14.5) in MSC and CON, resp], vs −1.8 ml/m 2 (−13.5;0.7) in EPC ( P =0.06). After EPC transfer, infarct size decreased more in segments with &gt;50% infarct transmurality ( P =0.01 vs MSC and CON). Myocardial perfusion increased more in EPC than in MSC and CON [RU +72% (−2;119) vs −2% (−28;84) and +25% (−33;236), resp], and was associated with greater vascular density in infarct border zones ( P =0.01) and with higher levels of pro-angiogenic growth factors, PLGF and FGF2 in EPC secretome (1730±1002 and 75±44 pg/10 6 cells resp vs 73±16 and 19±12 in MSC secretome,,n=5). No evidence of cell transdifferentiation was observed at 7w. Conclusion: Infusion of late-outgrowth EPCs after AMI limits negative LV remodeling but does not mediate cardiomyogenesis. EPC transfer may hold promise for heart failure prevention via paracrine matrix-modulating or pro-angiogenic effects.
Highlights
Journal: JAMA Oncology (2018)

Nab-paclitaxel vs Paclitaxel in HER2-Negative Breast Cancer 302The best neoadjuvant regimen for locally advanced breast cancer is elusive.Gianni et al questioned whether nab-paclitaxel was more effective than paclitaxel in achieving pathological complete remission (pCR) in patients with human epidermal growth factor receptor 2 (ERBB2/ HER2)-negative breast cancer.In this randomized clinical trial, 695 patients received paclitaxel or nab-paclitaxel.Intention-to-treat analysis revealed a nonsignificantly improved pCR rate after nab-paclitaxel vs paclitaxel.The data do not support the substitution of nabpaclitaxel for paclitaxel.Sparano provides an Editorial.
Intramyocardial Transplantation of Autologous Myoblasts
Authors: Bruno Pouzet, Jean-Thomas Vilquin, Albert A. Hagège, Marcio Scorsin, Emmanuel Messas, Marc Fiszman, Ketty Schwartz, Philippe Menasché
Journal: Circulation (2000)

Background —Autologous skeletal myoblast (SM) transplantation improves function of infarcted myocardium, but pretransplantation cultures remain a complex process. This study assessed whether it could be optimized by muscle preconditioning with the local anesthetic bupivacaine or even bypassed with the use of the so-called mince technique. Methods and Results —Muscle preconditioning consisted of intramuscular injections of the tibialis anterior of rats, 2 days before harvest. After 7 days of culture, the number of available myoblasts was significantly increased compared with nonconditioned controls (1 683 147 versus 85 300, P =0.0013). The mince technique was then assessed. A myocardial infarction was created in 66 rats by coronary artery ligation. One week later, rats were reoperated on and intramyocardially injected with culture medium alone (controls, n=23), autologous cultured SM (3.5×10 6 , n=21), or autologous muscle minced into a fine slurry, which was immediately transplanted (n=22). All muscles had been preconditioned. Left ventricular function was assessed by 2D echocardiography. Whereas end-diastolic volumes expanded over time in all groups, left ventricular ejection fraction (%, mean±SEM) was increased only in the cultured SM–transplanted group at 1 ( P =0.0006) and 2 months ( P =0.0008) versus baseline (37.52±1.92 and 40.92±2.17 versus 30.34±1.74), with a significant additional benefit between 1 and 2 months ( P =0.0069). Conclusions —Cell culture remains mandatory for SM transplantation to be successful but, in a clinical perspective, this process can be made more expeditious by preharvest muscle conditioning with bupivacaine, which greatly enhances the baseline cell yield.
HEAT PYREXIA
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Species with the genus Campylobacter
Authors: N. Wiegman
Journal: JAMA (1983)

<h3>In Reply.—</h3> Nelson Wiegman's letter has helped to demonstrate the confusion that exists regarding the nomenclature of species within the genus<i>Campylobacter</i>. Initially, the various species of<i>Campylobacter</i>were considered to be contained within the genus<i>Vibrio</i>, but because of glucose fermentative and DNA composition differences,<i>Vibrio</i>and<i>Campylobacter</i>species were separated. Essentially two<i>Campylobacter</i>human pathogens have been described and, until recently, had been termed<i>C jejuni</i>or<i>C fetus</i>subspecies<i>jejuni</i>and<i>C fetus</i>subspecies<i>intestinalis</i>.<sup>1</sup><i>Campylobacter fetus</i>subspecies<i>fetus</i>is the current term used rather than<i>C fetus</i>subspecies<i>intestinalis</i>, and it seems that<i>C jejuni</i>is now preferred rather than<i>C fetus</i>subspecies<i>jejuni</i>.<sup>1,2</sup> This recent change in terminology explains why Wiegman was unable to find reference to the<i>C fetus</i>subspecies<i>fetus</i>organism in the articles we used to support our discussion. Our isolate was identified by Gram's stain morphological testing, catalase and
SUBJECT INDEX
Journal: Circulation Research (1972)

Acetylcholine effects on His-Purkinje automaticity and conduction, 210 responses of heart cultures, 628 Acetylstrophanthidin effects on canine skeletal muscle vascular resistance, 274 Action potentials antiarrhythmic drugs and ouabain, 681 duration of premature, in Purkinje and ventricular fibers, 55 effects of acetylcholine on His-Purkinje automaticity and conduction, 210 effects of blood perfusion of canine Purkinje fibers, 575 electrophysiologic properties of isolated preparations of human atrial myocardium, 293 extracellular potentials related to intracellular, in dog Purkinje system, 505 potassium efflux from amphibian atrium during cardiac cycle, 350 Active state effect of caffeine and other methylxanthines on heart muscle, 367 velocity clamping in heart muscles, 310 Adenosine triphosphate metabolism in ischemia, 703 physical training and cardiac performance, 418 Adrenergic blocking agents antiarrhythmic drugs and ouabain, 681 Adrenergic mechanisms comparison of elastic and muscular arteries of rabbits, 541 Afterload spinal cardiocardiac reflexes, 158 Aging effects of hypertension on rat aortic wall and, 301 Aldosterone steady-state control analysis of renin-angiotensinaldosterone system, 713 Alpha receptors digitalis and muscle vascular resistance, 274 Amine extraction pulmonary extraction of 5-hydroxytryptamine and norepinephrine before and after cardiopulmonary bypass, 666 Amyl nitrite autonomic blockade and the baroreflex, 177 Anaphylatoxin complement-mediated vasoconstriction and graft rejection, 332 Anemia blood flow distribution on conscious dogs at rest and during exercise, 731 cellular hyperplasia and hypertrophy in cardiomegalies induced by anemia in rats, 104 Anesthesia regional hemodynamic effects of digitalis glycoside, 406 Angina pectoris subendocardial distribution
The American Medical Association's Diagnostic and Therapeutic Technology Assessment Program
Authors: R. J. Jones
Journal: JAMA (1983)

Since its founding, the American Medical Association has been actively engaged in the assessment and dissemination of new medical knowledge and new technologies. About two years ago, the Council on Scientific Affairs of the AMA recommended to its Board of Trustees that a plan be developed for establishing a mechanism within the AMA to briefly and promptly answer questions that might arise on the safety and effectiveness of medical technologies. The Board of Trustees of the AMA approved that idea. A plan was then developed and has now finally been implemented. It is important to put the new effort in context. The Council on Scientific Affairs of the AMA has for years been preparing reports for the profession on many areas of medical technology that have been of substantive interest to the public and the medical profession because of their unique popularity or their controversial nature. In the past four
ORIGINAL ARTICLES.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"DRUGS MANY: REMEDIES FEW."
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatrics
Authors: Julia A. McMillan
Journal: JAMA (1991)

As is so often the case in pediatrics, prevention, especially the use of vaccines, proved to be one of the major areas of attention during the past year. Other major developments included reports of a role for vitamin A for the possible prevention of millions of childhood deaths worldwide and the demonstration of a method for producing a more optimistic developmental outcome for the low-birth-weight infant. In October 1990 a diphtheria protein—conjugated<i>Haemophilus influenzae</i>type b vaccine (HibTITER, Praxis Biologics Inc, Rochester, NY) was licensed for use in infants beginning at 2 months of age.<sup>1</sup><i>Haemophilus influenzae</i>type b is the most frequent cause of invasive bacterial infection among children between the ages of 1 month and 3 years. Immunologic immaturity of infants and young children has made vaccine prevention for this most susceptible age group impossible in the past. Capsular polysaccharide vaccine (PRP) was licensed in the United
The physician's stake in animal research
Authors: J. B. Wyngaarden
Journal: JAMA (1986)

Practicing physicians of this nation have for years been partners with the biomedical research community, applying the results of research to prevent disease and to treat their patients. Data on the health status of Americans indicate that this partnership has been a fruitful one, leading to consistently improving health throughout the country. An important, but often forgotten, element associated with medicine's success story is the laboratory animal. Virtually every major achievement in medical research during the past century has depended, in one way or another, on the use of animals. We have had many successes, including the polio vaccine, bypass surgery, organ transplants, mood-controlling drugs, and a host of other important accomplishments. Nevertheless, the biomedical research community is being threatened by a small, but determined, segment of society that is opposed to the use of laboratory animals. Physicians and scientists at leading institutions are coming under increasing pressure from "animal
ADDRESS ON STATE MEDICINE.Delivered before the American Medical Association at the Forty-fourth annual meeting held at Milwaukee, June, 1893.
Authors: WALTER WYMAN
Journal: JAMA (1893)

THE EXTINCTION OF CONTAGIOUS DISEASES. <i>Mr. President, Ladies and Gentlemen</i>:—Is the idea utopian or has the time come in the history of the world when it should be considered a rational thought, worthy of serious contemplation? When a standard so lofty as this should be raised, and around it gather physicians, sanitarians and philanthropists fully determined upon a great struggle and animated by a reasonable confidence in ultimate success? Concerning the<i>great epidemic</i>diseases, encouragement may be found both by a reasoning from analogy, in the study of their respective histories, and in the contemplation of modern knowledge and methods. The history of the world shows us that whole races of men and other animals have become extinct. Why should not races of microbes become extinct? And certain diseases that once ravished the earth in epidemic form have so lost their inherent strength or have been so controlled in the
Update: Work-Related Electrocutions Associated with Hurricane Hugo—Puerto Rico
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Queries and Minor Notes.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal wall endometriosis following hypertonic saline abortion
Authors: B. T. Ferrari
Journal: JAMA (1977)

CUTANEOUS endometriosis is usually an easily detectable and treatable disease with a favorable prognosis. Although the lesion may occur in skin and subcutaneous tissue not violated by a surgical incision, there are numerous reports of endometriosis in operative scars. The following case illustrates the occurrence of endometriosis in the lower abdominal wall, following transabdominal hypertonic saline instillation into the uterus of a pregnant woman for elective abortion. <h3>Report of a Case</h3> A 28-year-old woman was referred to the University of California at Los Angeles Hospital surgical service for investigation of a firm mass in the lower midline abdominal wall. The patient first noted the mass seven years previously, three months after she had undergone a transabdominal hypertonic saline injection to induce abortion of a 20-week gestation. The operative record at the time of that abortion reported the use of an 18-gauge needle with stylet, penetrating the abdomen in the lower