tbuckley/cabot-search huggingface dataset:
OCCUPATIONAL HEALTH AND THE FAMILY PHYSICIAN
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Many cancer patients receiving THC as antiemetic
Authors: P. Gunby
Journal: JAMA (1981)

Tablets containing the active ingredient of marijuana, Δ<sup>9</sup>-tetrahydrocannabinol (THC), are being distributed by the National Cancer Institute (NCI), Bethesda, Md, for use by some patients undergoing cancer chemotherapy. The NCI officials estimate that at present 200,000 Americans may be taking drugs to combat cancer. Perhaps 50,000 of these patients experience refractory nausea and, while estimates vary, it is suggested that THC might help about one half of this group. The potential of THC for combating nausea has been studied since the early 1970s. Not long ago, the Food and Drug Administration finally accepted an advisory committee's recommendation that THC be made available to oncologists for antiemetic therapy (<i>JAMA</i>[MEDICAL NEWS] 1980;243:15-18,1980;244:754). Marijuana is still illegal for most other uses, however, and under the distribution program for cancer patients, hospital pharmacies that stock THC tablets must be approved by the US Department of Justice's Drug Enforcement Administration (DEA). Physicians
Phase III, randomized trial (CheckMate 057) of nivolumab (NIVO) versus docetaxel (DOC) in advanced non-squamous cell (non-SQ) non-small cell lung cancer (NSCLC).
Authors: Luis Paz-Ares, Leora Horn, Hossein Borghaei, David R. Spigel, Martin Steins, Neal Ready, Laura Quan Man Chow, Everett E. Vokes, Enriqueta Felip, Esther Holgado, Fabrice Barlesi, Martin Kohlhaeufl, Oscar Rodriguez, Marco Angelo Burgio, Jerome Fayette, Scott N. Gettinger, Christopher Harbison, Cécile Dorange, Friedrich Graf Finckenstein, Julie R. Brahmer
Journal: Journal of Clinical Oncology (2015)

LBA109 The full, final text of this abstract will be available at abstracts.asco.org at 2:00 PM (EDT) on Friday, May 29, 2015, and in the Annual Meeting Proceedings online supplement to the June 20, 2015, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.
Growing Fever.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Juan Rode, Pere Gine, Sheila Sherlock, Jean-Pierre Benhamou, Nicola Van Berckel, Gemma Lo ´pez, Roser Poblet, Xavier Forns, Hubert Blum, Erik Christensen, Michael Arthur, William Balistreri, Flavia Bortolotti, Italy Bosch, Spain Brissot, France Butterworth, Canada Roger, Jose Carrilho, Brazil Chang, Taiwan Chen, Taiwan Clavien, Switzerland De Mann, Netherlands Desmet, Belgium Dufour, Jean Franc, Switzerland Elias, Spain Rafael, Giovanna Fattovich, Angelo Gatta, Italy Geerts, Belgium Albert, Germany Guido, Andre Geubel, Belgium Gores, Japan Norio, Japan Hirohashi, Usa Jaeschke, David Jones, U Jones, E Anthony, Emmet Keeffe, Mexico David, Michael Kew, Africa South, Ralph Kirsch, Margaret Koziel, Switzerland Kullak-Ublick, Switzerland Lammert, Germany Frank, Jake Liang, Australia Stephen, Germany Ansgar, Anna Lok, France Marra, Italy Mato, Jose ´m, Spain Meijer, Netherlands The, Kevin Giorgina, Kingdom Moreno-Otero, Spain Moshage, Netherlands Navasa, Spain Negro, Niemela Onni, Finland O'grady, Japan Okita, Japan Kiwamu, Japan Omata, Italy Luigi, Italy Parola, Jean-Michel Pawlotsky, France Pietrangelo, Italy Antonello, Lawrie Powell, Australia Purcell, Robert Giovanni, Italy Rakela, Italy Franco, Japan Hirohito, Israel Ran, Berge Van, Jordi Bruix
Journal: Journal of Hepatology (2003)
Effect on Bronchial Asthma of Female Puberty and Adolescence
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beer, breast-feeding, and the wisdom of old wives
Authors: E. R. Grossman
Journal: JAMA (1988)

<h3>To the Editor.</h3> —As a practicing forensic pathologist, a university professor of the subject, and a chief editor of a forensic medical journal (<i>Forensic Science International</i>), I find it very disappointing that my field (forensic medicine or forensic pathology) is not mentioned in CONTEMPO '87.<sup>1</sup>Forensic medicine is an important teaching subject for medical students and, in its special way, it is a link between all the other medical specialties. I do hope that in the future similar surveys will also take forensic medicine into consideration.
Computerized surveillance of adverse drug events in hospital patients
Authors: D. C. Classen
Journal: JAMA (1991)

<h3>Objective.</h3> —To develop a new method to improve the detection and characterization of adverse drug events (ADEs) in hospital patients. <h3>Design.</h3> —Prospective study of all patients admitted to our hospital over an 18-month period. <h3>Setting.</h3> —LDS Hospital, Salt Lake City, Utah, a 520-bed tertiary care center affiliated with the University of Utah School of Medicine, Salt Lake City. <h3>Patients.</h3> —We developed a computerized ADE monitor, and computer programs were written using an integrated hospital information system to allow for multiple source detection of potential ADEs occurring in hospital patients. Signals of potential ADEs, both voluntary and automated, included sudden medication stop orders, antidote ordering, and certain abnormal laboratory values. Each day, a list of all potential ADEs from these sources was generated, and a pharmacist reviewed the medical records of all patients with possible ADEs for accuracy and causality. Verified ADEs were characterized as mild, moderate, or severe and as type A (dose-dependent or predictable) or type B (idiosyncratic or allergic) reactions, and causality was further measured using a standardized scoring method. <h3>Outcome Measure.</h3> —The number and characterization of ADEs detected. <h3>Results.</h3> —Over 18 months, we monitored 36 653 hospitalized patients. There were 731 verified ADEs identified in 648 patients, 701 ADEs were characterized as moderate or severe, and 664 were classified as type A reactions. During this same period, only nine ADEs were identified using traditional detection methods. Physicians, pharmacists, and nurses voluntarily reported 92 of the 731 ADEs detected using this automated system. The other 631 ADEs were detected from automated signals, the most common of which were diphenhydramine hydrochloride and naloxone hydrochloride use, high serum drug levels, leukopenia, and the use of phytonadione and antidiarrheals. The most common symptoms and signs were pruritus, nausea and/or vomiting, rash, and confusion-lethargy. The most common drug classes involved were analgesics, anti-infectives, and cardiovascular agents. <h3>Conclusion.</h3> —We believe that screening for ADEs with a computerized hospital information system offers a potential method for improving the detection and characterization of these events in hospital patients. (<i>JAMA</i>. 1991;266:2847-2851)
The Care of the Patient
Authors: Francis W. Peabody
Journal: JAMA (1984)

It is probably fortunate that systems of education are constantly under the fire of general criticism, for if education were left solely in the hands of teachers the chances are good that it would soon deteriorate. Medical education, however, is less likely to suffer from such stagnation, for whenever the lay public stops criticizing the type of modern doctor, the medical profession itself may be counted on to stir up the stagnant pool and cleanse it of its sedimentary deposit. The most common criticism made at present by older practitioners is that young graduates have been taught a great deal about the mechanism of disease, but very little about the practice of medicine—or, to put it more bluntly, they are too "scientific" and do not know how to take care of patients. One is, of course, somewhat tempted to question how completely fitted for his life work the practitioner of
Commentary
Authors: Kim Bennell, Peter Brukner
Journal: British Journal of Sports Medicine (2000)

Background-Bone must have suYcient strength to withstand both instantaneous forces and lower repetitive forces.Repetitive loading, especially when bone strain and/or strain rates are high, can create microdamage and result in stress fracture Aim-To measure in vivo strains and strain rates in human tibia during high impact and moderate impact exercises.Methods-Three strain gauged bone staples were mounted percutaneously in a rosette pattern in the mid diaphysis of the medial tibia in six normal subjects, and in vivo tibial strains were measured during running at 17 km/h and drop jumping from heights of 26, 39, and 52 cm.Results-Complete data for all three drop jumps were obtained for four of the six subjects.No statistically significant diVerences were found in compression, tension, or shear strains with increasing drop jump height, but, at the 52 cm height, shear strain rate was reduced by one third (p = 0.03).No relation was found between peak compression strain and calculated drop jump energy, indicating that subjects were able to dissipate part of the potential energy of successively higher drop jumps by increasing the range of motion of their knee and ankle joints and not transmitting the energy to their tibia.No statistically significant diVerences were found between the principal strains during running and drop jumping from 52 cm, but compression (p = 0.01) and tension (p = 0.004) strain rates were significantly higher during running.Conclusions-High impact exercises, as represented by drop jumping in this experiment, do not cause higher tibial strains and strain rates than running and therefore are unlikely to place an athlete who is accustomed to fast running at higher risk for bone fatigue.
Refugee Doctors
Authors: A. Gonzalez
Journal: BMJ (2003)

BBC Radio 4, 26 June at 8 pm Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> A doctor's job is not easy, but for doctors who come to the United Kingdom to escape wars and political persecution life can be particularly difficult. Not only have they been forced to flee their homes and leave behind family and friends, but they also have to learn a new language, face a new culture, and get to know new communities. Many find that they have to … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Diet and Dietetics.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The expanding network of redox signaling: new observations, complexities, and perspectives
Authors: Roy J. Soberman
Journal: Journal of Clinical Investigation (2003)

During the final stages of production, an error was introduced into the list of nonstandard abbreviations and into the text.The correct list of nonstandard abbreviations and the correct sentence appear below.Nonstandard abbreviations used: reactive oxygen species (ROS); hydrogen peroxide (H 2 O 2 ); hypoxia-inducible factor 1 (HIF-1); carboxy-terminal binding protein (CtBP); apoptosis-inducing factor (AIF); apoptosis signal-regulating kinase 1 (ASK1).Sensing nuclear oxygen tension.Since its original description, the study of the transcription factor hypoxia-inducible factor 1 (HIF-1) has demonstrated its central role in regulating the body's response to changing oxygen levels (4-6).
Omalizumab Facilitates Rapid Oral Desensitization for Peanut Allergy
Authors: Andrew J. Macginnitie, Rima A. Rachid, Antonella Cianferoni, Tina L.R. Dominguez, Jennifer Heimall, Melanie M. Makhija, Rachel Robinson, Sara V. Little, Hana Gragg, Paul Lakin, Tanya Logvinenko, Jennifer S. LeBovidge, Jennifer Koss, Megan T. Ott, Courtney B. Rooney, Dale T. Umetsu, Jacqueline A. Pongracic, Jonathan M. Spergel, Kari C. Nadeau, Lynda C. Schneider
Journal: Journal of Allergy and Clinical Immunology (2016)
National Cancer Mortality and Incidence in Japan
Authors: Minoru Kurihara
Journal: Environmental Health Perspectives (1979)

In Japan cancer mortality statistics have been prepared by site, sex, and age group since 1937. The trends in age-adjusted death rates for selected sites from 1937 to 1975 in intervals of two or three years, and the age-adjusted death rates for some sites by prefecture in 1968-1972 were summarized. Concerning the accuracy of cancer mortality statistics, special consideration should be given to senility in Japan. In 1975 deaths due to senility accounted for 4.3% of all deaths for all ages. Though the regional cancer registration was being operated in 16 prefectures in Japan as of 1976, the incidence rates were published for only six prefectures. The percentage of cases registered from death certificate only in six registries in Japan was compared with that in the registries in the United States, indicating that the completeness of registration was yet unsatisfactory in Japan. As an index of accuracy of diagnosis, the percentage of cases confirmed histologically was also compared.
Correction for Euro Surveill. 2019;24(13)
Journal: Eurosurveillance (2021)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Closure This is a corrected article applying to the following content: Outbreak of Salmonella enterica serotype Poona in infants linked to persistent Salmonella contamination in an infant formula manufacturing facility, France, August 2018 to February 2019
More children are being ventilated long term
Journal: BMJ (1999)

Nicotine nasal spray with patch is effective in stopping smoking On p 285 Blondal et al evaluate the efficacy of using a nicotine patch for 5 months with a nicotine spray for 1 year in stopping smoking.After 1 year, 27% of participants using the combined treatment were abstinent compared with 11% in the patch only group.Having access to nicotine in the nasal spray probably alleviated smoking urges.Five years after stopping treatment the difference in abstinence rates was double, emphasising the benefits of the combined treatment.
TAS-102 vs placebo (PBO) in patients (pts) ≥65 years (y) with metastatic colorectal cancer (mCRC): An age-based analysis of the RECOURSE trial.
Authors: Eric Van Cutsem, Fabio M. Benedetti, Hirokazu Mizuguchi, Robert J. Mayer, Atsushi Ohtsu
Journal: Journal of Clinical Oncology (2015)

3595 Background: TAS-102 is comprised of an antineoplastic thymidine-based nucleoside analog, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil hydrochloride, at a molar ratio of 1:0.5 (weight ratio, 1:0.471). Efficacy and safety of TAS-102 in pts with mCRC refractory to standard therapies were evaluated in the RECOURSE trial; enrollment criteria included ≥ 2 prior lines of standard chemotherapy. Primary results of RECOURSE demonstrated a significant improvement in overall survival (OS) (TAS-102 7.1 mo vs PBO 5.3 mo; HR=0.68; P<0.0001) and progression-free survival (PFS) (HR=0.48; P<0.0001). Methods: This prespecified analysis compared the efficacy and safety of TAS-102 vs PBO in pts ≥ 65 y and < 65 y with mCRC. A retrospective analysis of pts ≥ 75 y was also performed. Results: Of 800 randomized pts, 352 (44.0%) were ≥ 65 y and 60 (7.5%) were ≥ 75 y. Median OS in pts ≥ 65 y was 7.0 mo with TAS-102 vs 4.6 mo with PBO (HR=0.62, 95% CI: 0.48-0.80, P=0.0002). PFS HR was 0.41 (95% CI: 0.32-0.52, P<0.0001) for pts ≥ 65 y, also favoring TAS-102. In pts ≥ 65 y, disease control rate (complete or partial response or stable disease) was 48.7% with TAS-102 vs 15.5% with PBO. An age-related difference in overall incidence of adverse events (AEs) was not observed in either treatment arm. Treatment-related AEs, ≥ Grade 3 AEs, and severe AEs were generally more common in pts ≥ 65 y than in pts < 65 y (Table). Mean drug exposure was similar among pts ≥ 65 y and ≥ 75 y, as was overall safety profile. Conclusions: Significant improvements in OS and PFS were observed in pts ≥ 65 y who received TAS-102 vs PBO, with a mild increase in toxicity. Pts ≥ 65 y and < 65 y showed a generally favorable safety profile. A significant increase in toxicity in pts ≥ 75 y was not apparent vs the overall ≥ 65 y population. Clinical trial information: NCT01607957. TAS-102, < 65 y (n=299) TAS-102, ≥ 65 y (n=234) TAS-102, ≥ 75 y (n=36) Overall AEs, % 98.0 98.7 100 Treatment-related AEs, % 83.6 88.5 91.7 ≥ Grade 3 AEs, % 65.2 74.8 75.0 Severe AEs, % 28.8 30.8 33.3 Anemia, %* 23.4 41.9 44.4 Neutropenia, %* 25.8 32.5 33.3 Decreased platelets, %* 9.0 21.4 11.1 Decreased appetite, %* 23.7 29.9 22.2 *Treatment-related.
SUBPHRENIC ABSCESS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypomagnesemia. Suppression of secondary hyperparathyroidism in chronic renal failure
Authors: P. D. Miller
Journal: JAMA (1979)

Chronic renal failure is accompanied by secondary hyperparathyroidism. Inhibition of parathyroid hormone secretion has been reported to be induced by hypomagnesemia in conditions other than chronic renal failure, since severe hypomagnesemia is rare in chronic renal failure. In the case reported here, the patient had chronic renal failure and malabsorption-induced hypomagnesemia; she exhibited hypoparathyroidism while hypomagnesemic, and hyperparathyroidism after magnesium was replaced. Hypomagnesemia induced parathyroid hormone suppression in this patient with chronic renal failure, despite the presence of chronic hyperfunctioning parathyroid cells. (<i>JAMA</i>241:722-723, 1979)