tbuckley/cabot-search huggingface dataset:
New Congenital Disease Mechanism
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histoplasma Meningitis: A Study of Five Adult Patients
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors' reply
Authors: M. Regan
Journal: Annals of the Rheumatic Diseases (1996)

<h3>Abstract</h3> Bacteria can exhibit phenotypes, which makes them tolerant against antibiotics. However, often only a few cells of a bacterial population show such so-called persister phenotype, which makes it difficult to study this health-threatening phenotype. We recently found that certain abrupt nutrient-shifts generate <i>E. coli</i> populations that consist of almost only antibiotic tolerant persister cells. Such nearly homogeneous persister cell populations enable assessment with population-averaging experimental methods, such as high-throughput methods. In this paper, we provide a detailed protocol of how to generate such large fraction of tolerant cells using the nutrient-switch approach. Furthermore, we describe how to determine the fraction of cells that enter the tolerant state upon a sudden nutrient shift and describe a new way to assess antibiotic tolerance with flow cytometry. We envision that these methods facilitate research into the important and exciting phenotype of bacterial cells.
Dosage Errors
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Child abuse syndrome.
Authors: C Collins, Eileen Monrgomery, T Moore
Journal: BMJ (1972)

sary.The stimulation is used purely as an educational aid to increase the patient's awareness of the pelvic floor musculature in order that she can actively retrain the muscles herself by repeated exercises.It seems to be a reasonable rather than an extreme view to try to cure stress in- continence, for merely to control it with continuous electrical stimulation involves the permanent use of an electrode bearing device either in the vagina or anal canal and recurrent expense on batteries to the patient ad infinitum.It also seems reasonable to co- operate with physiotherapists whose special experience and skill can increase the effec- tiveness of these modern techniques.-Weare, etc.,
Filler: He died “peacefully” at home
Journal: BMJ (2003)

large cities in industrialised nations. 5This might be because tuberculosis may be suspected and investigated more readily among men or black or Asian people.Our study was limited by the amount of missing surveillance data.It was also impossible to determine the relative contribution of patient and healthcare provider to the total delay.Potential confounders-for example, coinfection with HIV or the accuracy of the data among patients whose first language was not English-were not taken account of.Recent campaigns have tried to raise awareness of tuberculosis, particularly among ethnic minority groups.Our data suggest that campaigns also need to be targeted at white people, who comprise a third of cases.We thank John Watson for access to the anonymised data from the national tuberculosis survey 1998.
Personal.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dysphagia for several years
Authors: D. A. Kumpe
Journal: JAMA (1971)

Dr. Kumpe: This 56-year-old woman had intermittent difficulty in swallowing for several years. She had occasional soft stools and some very intermittent diarrhea. These are two representative roentgenograms from x-ray series of the upper gastrointestinal tract, one obtained in 1966 and the other in 1970. <h3>Discussion</h3> Dr. Michael A. Glueck: There is dilatation and delayed emptying of the esophagus, as well as persistent dilatation of the second portion of the duodenum (Fig 1). The small bowel appears somewhat dilated, and the folds are normal or slightly prominent. The small bowel is not "wet"; that is, I don't see any evidence of segmentation of the barium sulfate column as it progresses through the small bowel. How long did it take for the barium to pass through the small bowel? Dr. Kumpe: It took several hours. The patient also had a barium enema examination of the colon, and roentgenograms of the chest
Reply
Authors: Bin Gao, Feng Hong, Svetlana Radaeva
Journal: Hepatology (2004)

We are grateful to Dr. Poupon for pointing out the potential involvement of cholestasis and bile salts in interferon (IFN)-α treatment failure in HCV patients. In the past few years, Dr. Poupon and his colleagues have demonstrated that cholestasis has a time-dependent inhibitory effect on 2′5′-oligoadenylate synthetase activity in the liver and spleen in a rat model of bile-duct ligation, and that physiological concentrations of bile salts can inhibit IFN-α-induced 2′5-oligoadenylate synthetase, MxA, and natural killer cell activities in cultured hepatocytes, HepG2 cells, Huh7, PLC/PRF-5, and CHO cells.1-3 These findings strongly suggest that cholestasis and bile salts may negatively modulate the efficacy of IFN-α treatment in hepatitis C virus (HCV) infection. Indeed, several studies, including one from Dr. Poupon's laboratory, show that cholestasis is a predictor of IFN-α treatment failure in HCV infection.4 However, recent clinical evidence from several studies suggests that patients with cholestatic viral hepatitis do respond to IFN-α antiviral therapy.5-8 For example, Gopal et al.reported that serum levels of HCV-RNA became undetectable in 4 of 7 cholestatic HCV patients after they received treatment with IFN-α2b and ribavirin.5 In a separate case report, a patient with acute HCV infection complicated with severe cholestasis was also successfully treated with IFN-α.8 Although treatment may not prevent progressive graft failure, combined IFN-α/ribavirin therapy appeared to inhibit HCV replication in severe recurrent cholestatic hepatitis C after transplantation.6 The success of IFN-α therapy in these patients may reflect findings from animal experiments, which have shown that IFN-α2b has antifibrotic and anticholestatic effects in a rat model of bile-duct ligation.9 Therefore, although we fully agree with Dr. Poupon that bile salts attenuate innate and acquired immunity as well as IFN-α signaling in the liver, we believe that observations of the effect of IFN-α treatment in cholestatic HCV infection are inconclusive. Further clinical studies are required to determine whether IFN-α treatment is effective in cholestatic HCV infection. Bin Gao M.D., Ph.D.*, Feng Hong M.D.*, Svetlana Radaeva Ph.D.*, * Section on Liver Biology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
Emergency Surgery. Part I; Part II
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fighting antimicrobial resistance on all fronts
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2017)

The theme of this year's World Antibiotic Awareness Week (Nov 13-19) is "seek advice". But what if your health professional's advice is not evidence-based? A trial in this month's issue aimed to reduce the shockingly high antibiotic prescribing rate among doctors providing outpatient care in China. In this setting in the rural west of the country, a staggering 80% of children aged between 2 and 14 years who are diagnosed with an upper respiratory tract infection (RTI) in an outpatient clinic receive a prescription for antibiotics.
Suicide among men in the highlands of Scotland.
Authors: I K Crombie
Journal: BMJ (1991)

by heterozygositv for cystic fibrosis would confer biological advantage.The AF508 is most common in white populations in the United Kingdom, United States, and The Netherlands but has a greatly reduced incidence in southern European populationss and in black and Mongoloid populations.Noticeably, fair skinned people are the most susceptible to melanoma and so would benefit the most from the possibly protective heterozygous state.Our finding of an inverse association between being a carrier of AF508 and melanoma was unexpected.It suggests that the presence of a genetic marker (or gene defect) may protect against melanoma.We thank L Meredith for providing some of the data on normal subjects; P Laidler, J A Whittaker, L Hughes, A Jacobs, and P Harper for providing clinical samples and useful discussion; and D C Hughes,
Learning theories and medical lectures: add little to little and there will be a big pile
Authors: Kirsti R. Dyer
Journal: JAMA (1989)

<h3>To the Editor. —</h3> I thoroughly enjoyed reading the commentary by Dr Cook.<sup>1</sup>As a medical student, I have found at least one instructor representative of each theory. However, one type of lecturer, whom I have encountered on numerous occasions, was not described. This is the practitioner of the exhumation theory. Practitioners of this method believe that all medical students have an unlimited amount of time, energy, and interest; that this is the only course worthy of a lifetime pursuit; and, of course, that medical school is the student's entire life. Lecturers assume that students will have the passion to dig down into, and eagerly wade through, multiple layers of minutiae to unearth, on their own, a few deeply buried pearls of wisdom. These pearls often appear so small and insignificant that they are readily overlooked. The first problem with this method is the failure of the instructor to
Two-Dimensional J-Resolved Nuclear Magnetic Resonance Spectral Study of Two Bromobenzene Glutathione Conjugates
Authors: J. A. Ferretti, R. J. Highet, L. R. Pohl, T. J. Monks, J. A. Hinson
Journal: Environmental Health Perspectives (1985)

The application of two-dimensional J-resolved nuclear magnetic resonance spectroscopy to determine the structure of two bile metabolites isolated from rats injected interperitoneally with bromobenzene is described. The structures of the two molecules are obtained unambiguously from the proton-proton spin coupling constants. This paper discusses the fundamentals of the technique and demonstrates the resolution of small long-range coupling constants.
Microelimination of chronic hepatitis C in Romania - another pathway to achieve national elimination goals by HepC ALERT project
Authors: Liliana Simona Gheorghe, Speranta Iacob, Laura Huiban, Monica Cojocaru, Camelia Cojocariu, Roxana Nemteanu, Irina Girleanu, Roxana Sirli, Ana Maria Singeap, Corina Pop, Dan Dumitrascu, Razvan Iacob, Mircea Mihai Diculescu, Anca Trifan, Ioan Sporea, Cristian Gheorghe
Journal: Journal of Hepatology (2020)
First Response
Authors: Jon O. Neher
Journal: Annals of Internal Medicine (2006)

On Being a Doctor21 February 2006First ResponseJon O. Neher, MDJon O. Neher, MDFrom Valley Family Medicine and University of Washington, Renton, WA 98055.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-4-200602210-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I was driving home from the symphony late one night through the downtown area. The traffic was closely spaced and moving quickly despite the rain and the slick road conditions. I had just passed the last of the downtown high-rises when suddenly a dozen red taillights flashed in front of me. I hit my brakes and was thrown into my safety belt. Traffic came to a full stop for a moment, and then began to inch forward again. In my peripheral vision, I caught sight of a pile of clothing lying in the center lane. At first I thought that ... Author, Article, and Disclosure InformationAuthors: Jon O. Neher, MDAffiliations: From Valley Family Medicine and University of Washington, Renton, WA 98055.Corresponding Author: Jon O. Neher, MD, Valley Family Medicine, 3915 Talbot Road South, Suite 401, Renton, WA 98055. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWillingness to perform mouth-to-mouth ventilation by health care providers: A survey 21 February 2006Volume 144, Issue 4Page: 301-302KeywordsAmbulancesBreathingDeceptionEmotionsSafetyShouldersStomachThoraxVision ePublished: 21 February 2006 Issue Published: 21 February 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Positive predictive value of screening mammography by age and family history of breast cancer
Authors: K. Kerlikowske
Journal: JAMA (1993)

<h3>Objective.</h3> —To determine the positive predictive value (PPV) of low-cost screening mammography according to age and family history of breast cancer. <h3>Design.</h3> —Cross-sectional. <h3>Setting.</h3> —Six counties in northern California. <h3>Participants.</h3> —A total of 31 814 women aged 30 years and older referred for mammography to the University of California, San Francisco, Mobile Mammography Screening Program from April 18, 1985, through November 20, 1992. <h3>Measurements.</h3> —Breast cancer risk profile, two standard mammographic views per breast, and follow-up of abnormal screening examinations. <h3>Results.</h3> —Although women aged 50 years or older constituted only 38.3% of all women who received first-screening mammography, 74% of breast cancers were detected in this group. Ten cancers were diagnosed per 1000 first-screening examinations in women aged 50 years or older, with 14.8 diagnostic procedures per cancer diagnosed compared with two cancers per 1000 screening examinations and 48.3 diagnostic tests per cancer diagnosed in women younger than 50 years. The PPV of first-screening mammography (number of breast cancers detected per abnormal examination) increased with age:.03 for those aged 30 to 39 years;.04 for those aged 40 to 49;.09 for those aged 50 to 59;.17 for those aged 60 to 69; and.19 for those aged 70 years or older (χ<sup>2</sup>for trend,<i>P</i>&lt;.001). Women aged 50 to 59 years had a higher PPV for first-screening mammography than women aged 40 to 49 years (.09 vs.04;<i>P</i>=.004), and women with a family history of breast cancer had higher PPVs compared with women without history (40 to 49 years of age,.13 vs.04,<i>P</i>=.01; and 50 to 59 years of age,.22 vs.09,<i>P</i>=.01). <h3>Conclusion.</h3> —Five times as many cancers per 1000 first-screening mammographic examinations were diagnosed in women aged 50 years or older compared with women aged less than 50 years. The highest PPVs for mammography were in women aged 50 years or older and in women aged 40 years or older with a family history of breast cancer. Efforts to promote screening mammography should focus on women in these groups, in whom the majority of breast cancers occur and for whom mammography has the highest PPVs. (<i>JAMA</i>. 1993;270:2444-2450)
PALLIATIVE SURGICAL OPERATIONS IN CHOKED DISC.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bioterrorism
Authors: Thomas May
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amphetamine Effects
Authors: Wolf F. C. Duvernoy
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Your recent MEDICAL NEWS section ofThe Journal(<b>214</b>:2260, 1970) has provoked some thoughts. First, the beneficial effects of amphetamines in the treatment of hyperkinetic children are described. According to several psychiatrists, these drugs appear to be the cure-all for simple problems that were formerly handled with a little authority and discipline in the classroom. I rather doubt that there was a true improvement of intelligence and achievement as was suggested by these tests. The reassuring statement was made "that most children outgrew the condition by their sixteenth year." This would then be the ideal age to switch over to the amphetamines, not as a treatment for the hyperkinetic syndrome but to get "highs" or to "go on trips" as is stated in an article in the very same section (<b>214</b>:2263) about "New 'Street Drugs' Add to Physician's Problems." As a nonpsychiatrist at times involved