tbuckley/cabot-search huggingface dataset:
Lindbergh's Birthplace
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Change in public perspective on cholesterol and heart disease. Results from two national surveys
Authors: B. Schucker
Journal: JAMA (1987)

The National Heart, Lung, and Blood Institute, Bethesda, Md, and the Food and Drug Administration, Washington, DC, sponsored two national probability telephone surveys (N = 4000) of adults to assess attitudes and knowledge about heart disease risk from high blood cholesterol levels and the public's efforts to lower blood cholesterol levels. The first survey was conducted in 1983, before release of the results from the Lipid Research Clinics Coronary Primary Prevention Trial, which showed that a reduction in the blood cholesterol level reduced coronary heart disease; the second survey was conducted in 1986. The percentage of adults who believed that reducing high blood cholesterol levels would have a large effect on heart disease increased from 64% in 1983 to 72% in 1986, so that the importance attached to reducing high blood cholesterol levels approached that attributed to reducing smoking and high blood pressure. In 1983,35% of adults reported that they had their cholesterol level checked vs 46% in 1986. In both years, diet changes were most frequently chosen (&gt;60%) as ways to control the blood cholesterol level; reducing dietary fat was believed to be as important as reducing dietary cholesterol. By 1986, 23% of adults reported that they made dietary changes specifically to lower their blood cholesterol level, up from 14% in 1983. These comparative data show gains in public awareness and action relating to high blood cholesterol level risk. The data can be used to develop education programs. (<i>JAMA</i>1987;258:3527-3531)
α-Thalassemia resulting from a negative chromosomal position effect
Authors: Virginia M. Barbour, Cristina Tufarelli, Jacqueline A. Sharpe, Zoe E. Smith, Helena Ayyub, Cynthia A. Heinlein, Jacqueline Sloane-Stanley, Karel Indrak, William G. Wood, Douglas R. Higgs
Journal: Blood (2000)
PURER FOODS AND DRUGS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Platelts VEGF concentantions in healthy controls volunteers and HCC patients submitted to percutaneously radiofrequency thermal ablation
Authors: G. Gadaleta-Caldarola, G. Ranieri, V. Fazio, A. Catino, C. D. Gadaleta
Journal: Journal of Clinical Oncology (2008)

15648 Background: Vascular endothelial growth factor (VEGF) is known to play a central role in tumour angiogenesis. Published data suggest that plasma rather than serum is the more suitable blood fraction for measuring VEGF in human cancer patients. The study aims to assess the plasma (P) P-VEGF levels in 20 healthy controls and 35 hepatocellular cancer (HCC) patients before and after percutaneously radiofrequency thermal ablation (PRFA), respectively. Methods: Enrolled patients showed: single lesion with a maximum diameter of 3.5 cm, no lymphnodal involvement and/or metastatic disease, no main portal vein thrombosis, no ascites, adequate liver functional reserve, A or B status according to Child-Pugh's classification. PRFA procedure was performed by using partially insulated needle electrodes (17.5 gauge; Tyco-Hospital Service, Pomezia Italy) placed under ultrasonographic guidance into the tumour to be ablated that inducing coagulative necrosis. In healthy volunteers and in HCC patients samples of blood were taken before, 2 and 5 days after PRFA respectively. Venous blood was dispensed into a into a sodium citrate, theophylline, adenosine, dipyridamole tubes for P (Becton Dickinson Hemogard Vacutainer Systems, Plymouth, UK). P samples were centrifuged at 180 × g × 10 min. The supernatant of P was removed obtaining a platelet-rich plasma P-RP. After removing the supernatant, the samples were again centrifuged at 1500 × g × 15 min to obtain a platelet-poor plasma P-PP. P-RP was treated with thrombin (Hemoliance Q.F.A. Thrombin Bovine) (80 μl/ml) obtaining a plasma activated platelet rich P-APR. VEGF levels were examined in all the above P fractions using the Quantikine Human VEGF-ELISA R&D Systems Inc., Minneapolis, MN). Results: A statistical significantly differentiation between healthy controls and HCC patients in P-RP VEGF level per platelet count was found (mean value: 1,6 pg/106 vs 0,3 pg/106 p=0.003 by t-test), while no significant change were found between pre- and post- VEGF levels in HCC patients. Conclusions: We suggest that platelets VEGF my play a role in HCC angiogenesis but it is not useful as early predictive marker of response to PRFA. No significant financial relationships to disclose.
Promotion of Gastrointestinal Tract Tumors in Animals: Dietary Factors
Authors: Paul M. Newberne, Thomas Schrager
Journal: Environmental Health Perspectives (1983)

The biological mode of action of tumor promoters, exemplified by the phorbol esters, is a subject of intensive study in a number of laboratories. A few investigators have recently begun to examine the role of dietary nutrients in tumor promotion, but the available data are sparse and interpretation difficult. A few examples are provided to indicate that some nutrients may be important in the promotion of cancer. However, the fine dividing line between effects on initiation or on promotion, so clearly shown in the mouse two-stage skin cancer model, is not so clear as yet in models used for studies in nutritional carcinogenesis. The animal models for these studies have been primarily rats, mice and hamsters. These have shown that nutrients which appear to have promotion activity are zinc deficiency and 13-cis-retinoic acid for the esophagus; vitamin A deficiency and lipotrope deficiency for the forestomach, unsaturated fat and vitamin A deficiency for liver and colon, lipotrope deficiency for the liver; selenium for the liver. It is probably more correct at this early stage of investigation to consider the effects of nutrients acting either during the time of exposure to the carcinogen, or, after such exposure and when no detectable carcinogen is found in the animals tissues, rather than as promoters in the strict sense.
Use of Adhesive Tapes for Closure of Scalp and Skin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Editor
Authors: Susan E. Bates
Journal: Clinical Cancer Research (2007)

The ability to identify cancer in its earliest stages represents a Holy Grail for oncologists, for the chance for a successful outcome is greatest then. However, in 2007, detection of minimal disease in the setting of recurrence or relapse offers a mixed picture. For the most part, we do not yet have the anticancer therapies that can eradicate cancer after it has recurred, no matter how early we detect the recurrence. While we hope that early detection of recurrence will improve outcome, we have no evidence of such, and at the moment, early detection of recurrence can introduce lead-time bias that may confuse our understanding of the efficacy of a given therapy. More to the point, who has not been in the unlucky situation of describing a positive FDG-PET study to an asymptomatic patient with no other evidence of disease? Nonetheless, we continue to seek methods of detecting cancer before clinical therapeutics have caught up with that capability.In this issue of CCR Focus, “Imaging Update: New Windows, New Mirrors”, Guest Editor Ronald Blasberg has assembled a talented group of contributors to consider emerging technologies and strategies for improved imaging of cancers as a means of identifying disease and as a means of detecting response to therapies. In addition to a clear and concise overview of the ever-changing imaging landscape, Blasberg also gives us his expert opinion on the translation of various imaging strategies to the clinic. Herein the reader will find skilled descriptions of DCE-MRI and its use in documenting blood flow following antiangiogenic therapy. (Jackson et al.); the use of 18F-FDG-PET and its role in staging cancer and in monitoring recurrence of disease (Mankoff et al.); new probes for PET imaging, including multiple example of probes already translated to the clinic (Wester); the use of MRI in a therapeutic maneuver—MRI-guided ultrasound to raise temperature at a tumor site to achieve an anticancer effect (Moonen); and the use of optical imaging derived from transfer of reporter gene constructs in animal models (Kaijzel et al.).Collectively these articles represent convincing proof that as new therapies do arrive, the windows and the mirrors will be there already. Perhaps that is as it should be.As with all issues of CCR Focus, it is hoped that these reviews will educate the interested non-expert and stimulate interest, encouragement, and inspiration for those laboring in the field.
Implementation of the Ottawa ankle rules
Authors: I. G. Stiell
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess the impact on clinical practice of implementing the Ottawa ankle rules. <h3>Design.</h3> —Nonrandomized, controlled trial with before-after and concurrent controls. <h3>Setting.</h3> —Emergency departments of a university (intervention) hospital and a community (control) hospital. <h3>Patients.</h3> —All 2342 adults seen with acute ankle injuries during 5-month periods before and after the intervention. <h3>Intervention.</h3> —The implementation of the Ottawa ankle rules by emergency department physicians. <h3>Main Outcome Measure.</h3> —Proportions of patients referred for standard ankle and foot radiographic series. <h3>Results.</h3> —There was a relative reduction in ankle radiography by 28% at the intervention hospital but an increase by 2% at the control hospital (<i>P</i>&lt;.001). Foot radiography was reduced by 14% at the intervention hospital but increased by 13% at the control hospital (<i>P</i>&lt;.05). Compared with nonfracture patients who had radiography during the after period at the intervention hospital, those discharged without radiography spent less time in the emergency department (80 minutes vs 116 minutes;<i>P</i>&lt;.0001), had lower estimated total medical costs for physician visits and radiography ($62 vs $173;<i>P</i>&lt;.001), but did not differ in the proportion satisfied with emergency physician care (95% vs 96%) or undergoing subsequent radiography (5% vs 5%). The rules were found to have sensitivities of 1.0 (95% confidence interval [CI], 0.95 to 1.0) for detecting 74 malleolar fractures and 1.0 (95% CI, 0.82 to 1.0) for detecting 19 midfoot fractures. In the following 12 months at the intervention hospital, use of radiography did not increase. <h3>Conclusions.</h3> —Implementation of the Ottawa ankle rules led to a decrease in use of ankle radiography, waiting times, and costs without patient dissatisfaction or missed fractures. Future studies should address the generalizability of these decision rules in a variety of hospital settings. (<i>JAMA</i>. 1994;271:827-832)
Vitamin E Supplementation, Cardiovascular Events, and Cancer
Authors: Alan R. Gaby
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Halothane arrhythmia
Authors: W. Silver
Journal: JAMA (1976)

<h3>To the Editor.—</h3> We would like to comment on the statement by Drs Marks and Wallace that "clinically significant arrhythmias rarely occur when halothane is used in healthy young adults (or children), and when they do occur, they are usually associated with additional intraoperative events such as endotracheal intubation or surgical stimulation" (236:139, 1976). For the past few months, we have studied standard lead II rhythm strips of infants and children admitted to the hospital for surgery. Our protocol calls for such rhythm strips to be taken before and after premedication, during induction of anesthesia, during various stages of anesthesia, and in the recovery area. The right panels of the Figure are examples of some of the arrhythmias that have developed with the use of halothane. The panels on the left represent the normal rhythm of these children before induction with halothane. Rhythm strip E' shows a bizarre chaotic pattern;
<i>A Primer of Psychology and Mental Disease for Use in Training-schools for Attendants and Nurses and in Medical Classes.</i>By C. B. Burr, M. D., Medical Director of Oak Grove Hospital for Nervous and Mental Diseases, Flint, Mich.; formerly Medical Superintendent of the Eastern Michigan Asylum; Member of the American Medico-Psychological Association, etc. Second edition, thoroughly revised. Pages ix-116. The F. A. Davis Co., Philadelphia, 1898
Journal: American Journal of Psychiatry (1899)
Adult Respiratory Distress Syndrome After Smoke Inhalation From Burning Poison Ivy
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stereoencephalotomy (Thalamotomy and Related Procedures). Part I. Methods and Stereotaxic Atlas of the Human Brain
Authors: WALTER FREEMAN
Journal: American Journal of Psychiatry (1953)

This volume summarizes an extensive program of research in a new and rapidly developing field of neurosurgery.The methods and equipment developed serve as the basis for future clinical investigation.There is little doubt concerning the value and great therapeutic possibilities of this method.The authors have produced a stereotaxic atlas of fundamental importance to those interested in this phase of neurosurgery.This volume is part one of a series.Subsequent parts yet to be published will deal with clinical problems and should prove of greater general interest to the pro-- fession.
Cancer mortality in India: a nationally representative survey
Authors: Rajesh Dikshit, Prakash C Gupta, Chinthanie Ramasundarahettige, Vendhan Gajalakshmi, Lukasz Aleksandrowicz, Rajendra Badwe, Rajesh Kumar, Sandip Roy, Wilson Suraweera, Freddie Bray, Mohandas Mallath, Poonam K Singh, Dhirendra N Sinha, Arun S Shet, Hellen Gelband, Prabhat Jha
Journal: The Lancet (2012)
"Brittle" diabetes.
Authors: S A Amiel
Journal: BMJ (1991)

not.Hence, of course, the scope for the export and import of ideas.The government's reforms can be interpreted as an attempt to inject American style incentives to providers even while maintaining the traditional advantages of the NHS.Similarly, any American reforms, if they come, are likely to revolve around attempts to introduce a British style single payer- with the capacity to cap budgets-while yet maintaining the flexibility, variety, and choice ofthe existing system.Whether either country can hope to have the best of every possible world remains to be seen.
Exogenous surfactants.
Authors: P Hope
Journal: BMJ (1991)

the screening programme, and the savings.Turning to the "good news" in his presentation, he illustrated how mathe- matical modelling could be used to analyse limited data in order to make better decisions.He asked the audience to imagine that they had $400m to spend on screening for a population of a million adults and to choose between cholesterol screening as recommended by the national cholesterol education programme and breast screening as recommended by the American Cancer Society.These are two of the best studied screening methods, and much of the information needed for making policy decisions is available.Cholesterol screening according to the recommended protocol could prevent 9620 events (including 340 sudden deaths, 2760 myocardial infarctions, and other conditions, some of them only poorly defined because of imprecise data) at a cost of $449m with a saving of $101m (net cost $348m); breast screening would save 222 lives at a cost of $296m but with a saving of only $5m (net cost $291m).A purchaser might thus opt for cholesterol screening, but Professor Eddy set his computer to adopt a more selective method of deciding who should be treated for hypercholesterolaemia-very much in the manner described in last week's BMJ by Professor Hugh Tunstall-Pedoe (28 September, p 744).The result is that you can prevent the same number of events with consequently the same saving (which is what Professor Eddy told his computer to do) at a cost of $192m, giving a net cost of $91m.The purchaser with $400m could then have both cholesterol and breast screening with $18m change.The computer could go further and be set to achieve higher benefits at lower costs.This is how important information can be, but one of the problems is that the information comes out of a mathematical model-and doctors feel uncomfortable with such models.The doctors who devised the national cholesterol education programme responded to his computer manipulation by saying that the protocol he had devised was too complicated to use.Professor Eddy is sympathetic but points out that medicine is far too complex an activity to be conducted by human minds unaided by computers: "We've been trying that
Screening for HTLV-III antibodies: the relation between prevalence and positive predictive value and its social consequences
Journal: JAMA (1985)

<h3>To the Editor.—</h3> We are concerned that in the recent article by Weiss et al,<sup>1</sup>some of the test operating characteristics reported may have been misleading. Specifically, the authors conclude that their screening test for human T-cell leukemia (lymphotropic) retrovirus type III (HTLV-III) antibodies (as a marker for the ability of a unit of blood to transmit acquired immunodeficiency syndrome [AIDS]) was "highly sensitive and specific" based on values calculated after "excluding borderline results." Neglecting these "borderline" results is inappropriate, as test results in the overlap zone between distributions for disease and nondisease actually<i>define</i>a test's sensitivity and specificity.<sup>2</sup> Sensitivity-specificity pairs for different cutoffs can be determined from data in the article's Table 1 (combining all patients with AIDS to define "disease" and Burlington blood donors to define "nondisease"). However, it may be more informative in examining a screening test to scrutinize the ratio of false-positives to