tbuckley/cabot-search huggingface dataset:
Variability in Chromosome Aberrations, Sister Chromatid Exchanges, and Mitogen-Induced Blastogenesis in Peripheral Lymphocytes from Control Individuals
Authors: Diana Anderson, Anne J. Francis, P. Godbert, P. C. Jenkinson, K. R. Butterworth
Journal: Environmental Health Perspectives (1993)

Confidence in results from monitoring genetic end points in environmentally or occupationally exposed individuals can be improved with knowledge of the normal variability of changes in genetic end points in the general population.Confounding effects can be determined, and study interpretation can be improved by correlation of this variability with various lifestyle factors such as sex and age, smoking and drinking habits, viral infections, exposure to diagnostic X-rays, etc. Eight blood samples were taken from each of24 male and 24 female volunteers over a period of2 years.Questionnaires pertaining to lifestyle were completed at the time of each sampling.Whole blood was cultured and slides prepared for chromosome abberration (CA) or sister chromatid exchange (SCE) analysis.Separated mononuclear cells were cultured with a range of phytohemag- glutinin concentrations, and the maximum level of mitogen-induced blastogenesis was determined by measurement of [3H]thymidine uptake.There was a significant effect of both year and season of sampling for all three end points.Because there was no consistent pattern in 2 successive years, effects were thought to be independent of season.No significant effects in any of the three end points were found with respect to sex or age nor any of the other lifestyle factors, although SCE frequency and mitogen-induced blastogenesis were nearly always higher in females than in males.These results point to the need for concurrent sampling of controls with exposed populations.
Outbreak of Acute Febrile Illness and Pulmonary Hemorrhage—Nicaragua, 1995
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors’ Index
Authors: E. Ringel, R.C.B. Aitken, P. Pinkerton, G.W.H. Leytham, J.C. Nemiah, F. Askevold, R. Baumann, Helgard Ziprian, I. Demel, J. Gordesch, H. Katschnig, W. Pöldinger, V. Scheiber, P. Sint, W. Gödicke, W. Hartrodt, Erna Naumann, J. Läuter, Edward Stonehill, A.H. Crisp, R.G. Priest, A.H. Crisp, R.G. Priest, M.A. Leibovich, F.H. Frankel, P. Hahn, H. Mayer, Brigitte Stanek, H. Mayer, Brigitte Stanek, P. Hahn, Brigitte Stanek, P. Hahn, F. Antonelli, L. Ancona, R. Pierloot, H. van Coppenolle, H. Mayer, R. Adler, F. Lomazzi, G. Koptagel, F. Reimann, P.D. Slade, G.F.M. Russell, A.J. Forrest, T. von Uexküll, M. Rotmann, W. Schüffel, R. Karstens, K. Köhle, C. Simons, B. Scholich, N. Schäfer, M. Jackson, C.P. Kimball, H. Freyberger, H.H. Wolff, Ida Cermak, P.E. Sifneos, A.H. Crisp, E. Stonehill, G.W. Fenton, P.B.C. Fenwick, C.P. Kimball, D. Quinlan, Florence Osborne, B. Woodward, A. Appels, H. Musaph, R. Kertesz, G.S. Philippopoulos, B. Luban-Plozza, A. Comazzi, C. Simons, K. Köhle, U. Genscher, M. Dietrich, C.L. Cazzullo, G. Invernizzi, R. Ventura, M. Sostero
Journal: Psychotherapy and Psychosomatics (1973)
THE TREATMENT OF ULCER AND CANCER OF THE STOMACH.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospital Staffing
Authors: M. M. Anderson, T. D. Anderson, G. H. Bancroft-Livingston, D. B. Brown, A. S. F. Butcher, J. A. Chalmers, H. V. Corbett, A. M. Dawson, J. F. Foulkes, A. G. Gordon, J. S. Hesketh, J. H. Hughes, H. J. G. Kersey, G. d. B. Mitford-Barberton, A. S. Moolgaoker, P. R. Payne, P. R. B. Pedlow, J. A. Riedel, H. A. Ripman, G. M. Smith, R. H. Stearn, A. J. White, J. K. Wilson, R. T. Booth
Journal: BMJ (1972)
Intracardiac injections during resuscitation
Authors: Ronald W. Yakaitis
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Davison and his colleagues have performed a muchneeded service in reporting their experience with ICIs during resuscitation. Nevertheless, I still have difficulty accepting ICI as a customary route of drug administration, and I fear that their article may be construed as a blanket recommendation of ICI as an arbitrary option to IV drug administration. In an effort to counter this possibility, there are several points concerning ICI and this report that should be discussed. First, the authors observed hemopericardium to be a relatively common but clinically insignificant complication of ICI. I submit that it would be difficult, in the heat of initial resuscitative attempts, to assess whether tamponade is either present or exerting any appreciable detrimental effect. Moreover, figures derived from living subjects regarding the relationship between tamponade and the rate of pericardial sac fluid accumulation may bear little, if any, resemblance to the hemodynamic situation in
Effects of competition in medicine
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shöshin Beriberi
Authors: Paul L. Wolf, Murray B. Levin
Journal: New England Journal of Medicine (1960)

BERIBERI obviously is not a disappearing disease, but the pattern of incidence has changed. Shöshin beriberi is probably not an uncommon disease in the United States, but the few reports in the English literature indicate that it is rarely diagnosed.Cardiac beriberi is arbitrarily divided into the acute fulminant form and the chronic type. Shöshin beriberi is the fulminant form of beriberi heart disease, which is characterized by acute cardiovascular collapse. Death may occur within hours. Shöshin is the Japanese term for acute cardiac catastrophe ("sho" meaning acute damage, and "shin" meaning heart). The term beriberi is most probably of . . .
NEW LIGHT ON MALARIA.
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
VENTRICULAR BAND SPEECH IN HYSTERIC APHONIA.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase II trial of thymidine and carboplatin for recurrent malignant glioma: A North American Brain Tumor Consortium Study
Authors: H. Ian Robins, Susan M. Chang, Michael D. Prados, W.K. Alfred Yung, Kenneth Hess, David Schiff, Harry Greenberg, Karen Fink, Kelly Nicolas, John G. Kuhn, Timothy Cloughesy, Larry Junck, Minesh Mehta
Journal: Neuro-Oncology (2002)

This phase II study in recurrent high-grade glioma evaluated the response rate, toxicities, and time to treatment failure of high-dose carboplatin modulated by a 24-h infusion of thymidine (75 g/m2). The trial was based on preclinical data and a prior phase I study (J. Clin. Oncol. 17, 2922-2931, 1999); a phase II recurrent high-grade glioma study was initiated in July of 1998. Thymidine was given over 24 h; carboplatin was given over 20 min at hour 20 of the thymidine infusion. The starting dose of carboplatin had a value of 7 for the area under the curve (AUC), with allowance for dose escalation of 1 AUC unit per cycle if grade 2 toxicity was observed. Treatment cycles were repeated every 4 weeks. Accrual as of September 1999 was 45 patients [4 were unevaluable]: 76% with glioblastoma multiforme (GBM), 20% with anaplastic oligodendroglioma, 2% with mixed type, and 2% with anaplastic astrocytoma. Most patients had prior chemotherapy (78%). As observed in the earlier phase I study (in which carboplatin pharmacokinetics were unaltered by thymidine or antiseizure medications), thymidine was myeloprotective, resulting in a minimal need for dose reduction for patients having a >2 grade toxicity (in only 4% of the courses of treatment). Of 101 total courses, the number of courses (at the AUCs) was 3 (5), 4 (6), 58 (7), 20 (8), 11 (9), and 5 (10). Grade 3 non-hematologic toxicities included headache (4%), altered consciousness (3%), fatigue (1%), and nausea (3%). Responses included 2 partial (1 oligodendroglioma, 1 GBM; 5%); 3 minor (1 anaplastic astrocytoma, 2 GBM; 7.3%); 6 stable disease (14.6%); and 30 progressive disease (73.2%). For GBM patients, median survival was 23 weeks (with a 95% confidence interval of 20 to 50 weeks), and progression-free survival was 8 weeks (with a 95% confidence interval of 7-16 weeks). These results in GBM were comparable to other phase II GBM trials and thus do not represent a therapeutic advance in the treatment of GBM. Taken collectively, however, results are consistent with continued investigation of thymidine in combination with chemotherapeutic agents for high-grade glioma and other malignant diseases. The significant myeloprotection afforded by thymidine may have particular relevance to polychemotherapeutic regimens.
The Epigenetics of Multiple Sclerosis: Clues to Etiology and a Rationale for Immune Theory
Authors: L Steinman
Journal: Annual Review of Neuroscience (1994)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Walter B. Cannon
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Triazinate and Platinum Efficacy in Combination With 5-Fluorouracil and Doxorubicin: Results of a Three-Arm Randomized Trial in Metastatic Gastric Cancer
Journal: JNCI Journal of the National Cancer Institute (1988)

The Gastrointestinal Yumor Study Group compared three regimens in a controlled Prospectively randomized trial for the treatment of patients with advanced gastric cancer. All regiments contained 5-fluorouracil and doxorubicin (FA) but differed in the third drug: semustine (Me), triazinate (T), orcisplatin (P). FAT produced significantly superior overall survival (p<.01) compared to FAMe. One-year survival rate for the FAT regimen was 30% compared to 15% for the FAMe regimen, and median survival times were 30 versus 24 weeks, respectively. The FAP regimen demonstrated a similar survival advantage compared to the FAMe regimen. The improved survival was observed despite decreased 5-fluorouracil and doxorubicin dosages for patients on the FAT and FAP arms. Severe toxicity rates were 42% for FAT, 69% for FAP, and 62 for FAMe. The FAT regimen produced significantly less hematologic toxicity than either FAP or FAMe, while mild neurotoxicity was the limiting toxicity of cisplatin in this study. Two classes of drugs, without known risks of potentially fatal long-term toxic effects, appear to be effective substitutes for long-acting alkylating agents such as Me or miltomycin in the treatment of advanced gastric cancer. Thease findings identify new approaches to therapy for this common diseas. [J natl cancer Inst 1988;80:1011–1015]
Time course of histological progression in primary biliary cirrhosis
Authors: G LOCKE
Journal: Hepatology (1996)

Histological staging is used for stratification and assessment of treatment efficacy in therapeutic trials for primary biliary cirrhosis (PBC). Knowledge of the rate of progression of the histological changes would be helpful in the design (duration) and conduct of clinical trials. The histological stages were recorded for liver biopsies performed annually on 222 patients during a randomized, placebo- controlled clinical trial in which therapy with D-penicillamine (DPCA) was shown to be ineffective. These data were analyzed using a Markov model to describe the time course of histological progression in PBC. At study entry, 15 patients were stage I, 56 were stage II, 96 were stage III, and 55 were stage IV. Histological progression was observed after 1 year in 41%, 43%, and 35% of the patients, and after 2 years in 62%, 62%, and 50% of the patients who were stage I, stage II, and stage III at entry, respectively. After 4 years biopsies showed cirrhosis in 31% and 50% of the patients in stage I and stage II at entry, respectively. A minority (20%) of the precirrhotic patients showed histological stability; sustained histological regression was rarely observed (2%). Our data suggest that a majority of patients with PBC will progress histologically within 2 years. The distribution of histological stages over time may be helpful in determining the number of patients and length of time necessary to appreciate a treatment effect on histological progression in clinical trials for PBC.
Cryptosporidiosis Outbreaks Associated With Recreational Water Use — Five States, 2006
Journal: JAMA (2007)

Cryptosporidiosis is a gastrointestinal illness caused by parasitic protozoa of the genus Cryptosporidium and can produce watery diarrhea lasting 1-3 weeks; one or two cases per 100,000 population are reported annually in the United States. Fecal-oral transmission of Cryptosporidium oocysts occurs through ingestion of contaminated drinking or recreational water, consumption of contaminated food, and contact with infected persons or animals (e.g., cattle or sheep). Unlike bacterial pathogens, Cryptosporidium oocysts are resistant to chlorine disinfection and can survive for days in treated recreational water venues (e.g., public and residential swimming pools and community and commercial water parks) despite adherence to recommended residual chlorine levels (1-3 ppm). For 2006, a total of 18 cryptosporidiosis outbreaks have been reported (as of July 24, 2007) to CDC's U.S. Waterborne Disease and Outbreak Surveillance System, compared with five outbreaks reported for 2003 and seven for 2004; data for 2005 and 2006 are not yet final. This report describes five laboratory-confirmed cryptosporidiosis outbreaks in 2006 that involved public recreational water use. The popularity of recreational water venues, the number and geographic distribution of recent cryptosporidiosis outbreaks, and the resistance of Cryptosporidium to chlorination suggest that treatment strategies for recreational water facilities need to be improved.
Gastroscopy in clinical medicine
Authors: F. Steigmann
Journal: JAMA (1967)

Gastroscopy, the examination of the interior of the stomach, originated in 1873 when Kussmaul introduced a 13-mm-caliber metal pipe into the stomach of a professional sword swallower. It was Mickulicz, however, who in 1881 first visualized the pylorus and thus stimulated many others to study this procedure. It was not until 1910 that Loening and Stieda produced the first, easily usable, nonflexible gastroscope. In 1923, Schindler<sup>2</sup>presented an atlas of colored gastroscopic pictures, the result of many examinations without untoward reactions and thus removed the fear of gastroscopy. His introduction in 1932 of the flexible Wolf-Schindler gastroscope heralded a new era, since the new scope made gastroscopy easier, almost dangerless, and a routine procedure in many hospitals, thus aiding in the solution of many diagnostic and therapeutic problems in stomach diseases. <h3>Gastroscopy as a Diagnostic Tool</h3> Gastroscopy, which started in Germany but flourished in the United States since 1932 under
Psychiatric Epidemiology
Authors: M Tohen, E Bromet, J M Murphy, M T Tsuang
Journal: BMJ (1963)

Psychiatric epidemiology is considered one of the main scientific foundations of psychiatry. This article reviews methodological issues and major studies in psychiatric epidemiology. Methods such as measures of frequency and association are discussed. Selection, observation, and confounding, the main sources of bias in epidemiological studies, are described. Types of study designs, such as cross-sectional, cohort, and case-control, are detailed. A historical perspective of major population-based and clinical studies is presented. Major findings of the Epidemiologic Catchment Area Study and the National Comorbidity Survey are also included. Finally, future directions in the field are discussed.
PARENTERALLY ADMINISTERED NITROGEN
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal