tbuckley/cabot-search huggingface dataset:
Clinical and pathologic correlation of the activated form of the androgen receptor (AR) in breast cancer (BC).
Authors: Philippe Jamme, Jacques Bosq, Erard M. Gilles, Alexander Zukiwski, Charline Alleaume, Ambroise Gilles, Jacques Bonneterre
Journal: Journal of Clinical Oncology (2014)

590 Background: The Androgen Receptor is present in BC, and ongoing studies are testing the activity of antiandrogens in BC. AR has been associated with a better prognosis in ERα positive tumors. AR has a nuclear biology dynamics common to the steroid nuclear receptors. In the absence of ligand, it is evenly distributed in nuclei; when exposed to androgens, it migrates to form sub-nuclear aggregates that can be detected by fluorescence microscopy. Thus, two distinct nuclear patterns, diffuse (D) or aggregated (A), correspond to two receptor functional states. Similarly to previous work on ER and PR (ASCO 2013 abstr # 11535 & 593), we have devised an immunohistochemical (IHC) method to characterize the nuclei patterns that may indicate whether AR is transcriptionally active or not in PEFF tissues. The goal of this study is to explore the AR biological or clinical relevance. Methods: As of February 4th, 662 archived BC biopsies have been obtained along with associated clinical data. Biopsies were analyzed for standard HES, ER, PR, AR and Ki67. AR positivity was determined with clone AR27 antibody (Novocastra). The A-AR (aggregated AR) and D-AR (diffuse AR) pattern were analyzed at x1000 magnification. Results: 490 cases have been analyzed to date. Mean Age: 57 (17-89). Histology: ductal 82%, lobular 15%, and other 3%; ERapos , 78%, PRpos 78%. Adj Chemotherapy 46% Hormonotherapy 85%. Stage I 44%, II 48%, III 8%. Grade I 25%, II 50%, III 25%. AR was positive (ARpos) in 51%. AR status was diffuse (D-AR) in 66% and aggregated (activated, A-AR) in 34% of the ARpos biopsies. ARpos and D-AR were associated with lower Grade (p < 0.04, p = 0.1), ERα (p <0.000,= 0.03), PR (p <0.000, 0.1), but not HER2, Ki67, or Staging. Median follow up was 36 months (mo). Progressive disease (PD), local or distant, was 19%, and PD was not associated with A-AR (p=0.25). With DFS defined as time to PD or death (5 year cut-off), ARposwas associated with a HR of 0.61 (p = 0.08) but not in a Cox model including both AR and ER positivity (HR for ER = 0.41, for AR 0.92, with p = 0.006 and 0.8 respectively). When added, grade was an independent predictor (HR= 0.44, p = 0.004). Conclusions: A-AR is associated with grade and other steroid receptors suggesting biological relevance.
Sexual Neurasthenia ( Nervous Exhaustion ), Its Hygiene, Causes, Symptoms and Treatment, with a Chapter on Diet for the Nervous by George M. Beard, A.M., M.D.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the author
Authors: K. A. Franklin
Journal: European Respiratory Journal (2007)

Screening for sleep-disordered breathing is recommended in patients with chronic heart failureTo the Editors:In a recent editorial in the European Respiratory Journal, K.A. Franklin criticised the screening of heart failure patients for sleep-disordered breathing (SDB) [1].The major concern was that, to date, no beneficial effect on overall prognosis has been shown for any therapeutic option, e.g.nocturnal oxygen, continuous positive airway pressure (CPAP) or adaptive servoventilation (ASV).
Cerebrospinal Fluid Pressure Changes in Fractional Pneumoencephalography Without Removal of Cerebrospinal Fluid
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The primary empty sella syndrome. Diagnosis with metrizamide cisternography
Authors: W. F. Young
Journal: JAMA (1981)

EMPTY sella syndrome occurs when the suprasellar subarachnoid space extends into the sella turcica. The primary syndrome presents in a patient with no prior history of pituitary radiation or surgery,<sup>1</sup>is benign, and requires no therapy unless there is progressive visual field loss, rhinorrhea, or an associated microadenoma.<sup>2</sup>The correct diagnosis is crucial to avoid unnecessary surgical or radiation therapy for a suspected intrasellar tumor. The radiological evaluation has recently improved with the use of intrathecal metrizamide (Amipaque) and computed tomography (CT).<sup>3-5</sup>This report presents a case of the primary empty sella syndrome with associated bitemporal visual field defects definitively diagnosed with metrizamide cisternography and correlative CT. Also, the endocrinologic presentation of this syndrome with associated visual field defects is further defined. <h3>Report of a Case</h3> A 32-year-old, healthy married woman had "floating spots" in her eyes for three years and recent onset of blurring vision. She
TECHNIQUE OF INTESTINAL BIOPSY
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Concurrent application of tretinoin (retinoic acid) partially protects against corticosteroid-induced epidermal atrophy
Authors: A.J. MCMICHAEL, C.E.M. GRIFFITHS, H.S. TALWAR, L.J. FINKEL, E.S. RAFAL, T.A. HAMILTON, J.J. VOORHEES
Journal: British Journal of Dermatology (1996)
THE DIFFUSION OF SMALLPOX.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Economics
Authors: J. M. Eisenberg
Journal: JAMA (1992)

In the election year of 1992, health insurance has been a central issue in the campaigns of politicians of every stripe. As the old saying goes, "Politics makes strange bedfellows," and so it is with health insurance. The business community is concerned that the cost of medical care makes the price of doing business in the United States too high. Middle-income Americans are worried that they cannot afford adequate health insurance. The poor are convinced that their medical care is excessively and unjustly rationed because they cannot buy access to it and because public programs are insufficient for them to gain entry to mainstream medical care. Recent health services research has investigated the economics of access to care and has demonstrated that the problem is real and serious. Physician visits for low-income Americans decreased 8% during the middle 1980s, while visits for others, even controlling for the lower use expected
Dermatology
Authors: John Godwin Downing
Journal: New England Journal of Medicine (1959)

IF a person lives long enough, he or she undoubtedly will suffer a skin disease — probably a dermatitis from an irritant or sensitizer, or perhaps psoriasis or a skin cancer. These conditions constitute the bulk of the practice of the busy dermatologist. If seen at the onset, practically all these diseases can be controlled or relieved. However, despite enormous research, clinical knowledge and experience, little is known about the prevention of these common skin diseases. The teaching dermatologic clinics are conducting numerous studies in the anatomy, physiology and biochemistry of the skin.The trend is toward the appointment of . . .
Consequences of Selling a Kidney in India
Authors: S. S. M. Razvi
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocardial Contusion
Authors: Robert J. Rothstein
Journal: JAMA (1983)

MYOCARDIAL contusion was described as early as 1676,<sup>1</sup>with the first autopsy-proved case reported by Akenside<sup>2</sup>in 1764. Approximately 15% of victims of fatal chest trauma have myocardial contusions demonstrated at autopsy,<sup>3</sup>and between 9% and 76%<sup>4</sup>of victims of major trauma have been reported to suffer from this disease entity. Contusions to the heart may occur without obvious serious external injury, but the incidence of such is totally unknown. Despite extensive clinical experience and experimental data, we still lack definitive criteria for the clinical diagnosis and are without a readily available, noninvasive, sensitive, and specific diagnostic test to recognize myocardial contusion. Thus, the clinician who deals with seriously traumatized patients is left with the age-old tool, the "index of suspicion," in diagnosing myocardial contusion. The purpose of this article is to review current clinical criteria and modalities commonly used to diagnose myocardial contusion as well
STATE MONTHLY JOURNALS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New association looks at environmental hazards; groups worldwide ponder challenges involved
Authors: C. Marwick
Journal: JAMA (1993)

CONCERNED ABOUT deleterious effects of environmental pollution on the nation's health, a group of health professionals is forming the National Association of Physicians for the Environment. Their object in bringing together physicians, other health professionals, government officials, and environmental organization representatives is to draw up a program for dealing with hazards to health in living and working environments. The group held its first national conference in Washington, DC, in association with the American Academy of Otolaryngology—Head and Neck Surgery. The association was incorporated just 2 months ago, according to John Grupenhoff, PhD, Science and Health Communications Group, Bethesda, Md, who says: "It seems to me that every environmental or pollution problem is or will become a medical or public health problem. Thus, pollution prevention can be disease prevention." Grupenhoff says that, based on his work to date with medical specialty societies, he feels they are in a position to make
Pictorial Cardiology
Authors: A. Hollman
Journal: BMJ (1970)

<h3></h3> <b>Background:</b> Peritonsillar abscess (PTA) is a common occurrence in adult patients, and an important question in such often-seen disease processes is whether we are treating these patients effectively, efficiently, and economically. We sought to determine if a diagnostic computed tomography (CT) scan was associated with a difference in clinical intervention in adult patients with PTA and if CT was associated with delaying this intervention. <b>Methods:</b> We conducted a retrospective case-control study examining therapeutic interventions in adults with PTA. Patients were divided into a control group (those diagnosed without CT, n=159) and a case group (those diagnosed with CT, n=203). Patients were examined for 3 outcomes: admission, bedside procedure (needle aspiration, incision/drainage), and surgical procedure (incision/drainage, tonsillectomy). In addition, we calculated times to admission, otolaryngology consultation, bedside procedure, and surgical procedure. <b>Results:</b> We found a significant association between CT and intervention, with the CT group more likely to be admitted (<i>P</i>&lt; 0.001), the non-CT group more likely to undergo a bedside procedure (<i>P</i>&lt;0.001), and the CT group more likely to undergo operative intervention (<i>P</i>=0.02). Mean times to otolaryngology consultation, admission, and bedside procedure were significantly longer in the CT group than in the non-CT group, determined by calculating the difference of the means with 95% confidence intervals for each comparison (<i>P</i>&lt;0.001). <b>Conclusion:</b> We found that CT scans appear to be useful in the workup and treatment of adult patients with PTA, evidenced by significant differences in interventions between groups with and without CT scans. We also found that CT scans have the potential to delay these interventions, as the time to each intervention examined was significantly longer in patients who had a CT scan. Given the need to reduce cost, enhance efficiency, and eliminate harmful side effects (in this case, radiation exposure and delays in care), we question whether CT is the gold standard imaging method for diagnostic work up of PTA.
Progressive Supranuclear Ophthalmoplegia
Authors: Michael A. Schleider
Journal: JAMA (1977)

PROGRESSIVE supranuclear ophthalmoplegia (PSO) was found to be the underlying cause of cricopharyngeal dysfunction and secondarily of recurrent pneumonia in an elderly patient. The purpose of this report is to call attention to a treatable cause of recurring pneumonia in the elderly. <h3>Report of a Case</h3> A 75-year-old man was admitted to the New York Hospital in January 1974 for treatment of acute pneumonia. During the two preceding years, he experienced dysphagia and a 23-kg weight loss and required two hospital admissions because of recurrent episodes of bronchitis and pneumonia. During one of these admissions, the diagnosis of PSO was suggested strongly by the presence of supranuclear ophthalmoplegia, dysarthria, dysphagia, dystonic rigidity, bradykinesia, and a mildly ataxic gait. His past medical history included peptic ulcer disease (treated with a partial gastrectomy and an end-to-side gastrojejunostomy), Laënnec cirrhosis, and nonmetastatic prostatic adenocarcinoma. A history suggesting Raynaud phenomenon was later elicited, but
Insanity in Egypt.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Statistics
Authors: David L. Streiner
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biochemical and Physiological Effects of Chlordimeform
Authors: F. Matsumura, R. W. Beeman
Journal: Environmental Health Perspectives (1976)

Chlordimeform is a relatively new acaricide/insecticide, whose mode of action we have investigated. It appears to interfere with amine-mediated control of nervous and endocrine systems in a variety of ways. Specifically, chlordimeform causes a build-up of the amines 5-hydroxytryptamine and to a lesser extent norepinephrine in the rat brain in vivo, antagonizes the in vivo action of reserpine in the rat (reserpine depletes amine stores in the CNS), inhibits monoamine oxidase from rat liver in vitro, and causes hypotension in rabbits. In the American cockroach it directly stimulates the heart in situ, acts synergistically with tryptamine in vivo, inhibits amine-N-acetyltransferase from cockroach head in vitro, causes accumulation of indolamines in cockroaches in vivo, and blocks the stimulation of adenylate cyclase by octopamine in the cockroach CNS in situ. It also inhibits tryptamine metabolism in whole mites in vitro.