tbuckley/cabot-search huggingface dataset:
Differentiation of Pulmonary Vascular from Parenchymal Diseases by Ventilation/Perfusion Scinitiphotography.
Authors: Kenneth M. Moser
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Differentiation of Pulmonary Vascular from Parenchymal Diseases by Ventilation/Perfusion Scinitiphotography.Kenneth M. Moser, M.D., F.A.C.P., Michel Guisan, M.D., William L. Ashburn, M.D.Kenneth M. Moser, M.D., F.A.C.P.Search for more papers by this author, Michel Guisan, M.D.Search for more papers by this author, William L. Ashburn, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-808_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past, defects observed in pulmonary perfusion scintiphotography often have been equated with the diagnosis of pulmonary embolism. In fact, such defects lack diagnostic specificity since many other disease processes can alter regional lung blood flow and produce such defects. Physiologic-anatomic considerations suggested that specificity might be gained by combining ventilation with perfusion radionuclide studies. This possibility has been explored in a large series of patients with known or suspected pulmonary disease.Distribution of pulmonary blood flow was determined by intravenous injection of133Xenon-in-saline or131Iodine-labelled albumen macroaggregates. Distribution of ventilation was determined by inhalation of133Xenon gas. A... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: La Jolla, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPulmonary involvement in Fabry's disease: A reappraisal 1 May 1970Volume 72, Issue 5Page: 808-808KeywordsBlood flowInhalationIntravenous injectionsLungsPulmonary diseasesPulmonary embolismPulmonary vascular diseasesRadionuclide imagingSpecificityVascular diseases Issue Published: 1 May 1970 PDF DownloadLoading ...
German Investigations on Morbidity and Mortality of Workers Exposed to Vinyl Chloride
Authors: H. Weber, W. Reinl, E. Greiser
Journal: Environmental Health Perspectives (1981)

Two studies on mortality and morbidity of workers exposed to vinyl chloride monomer (VCM) which have been carried out on behalf of the Ministry of Labour, Health and Social Affairs on Northrhine-Westphalia are reported.
A phase II study of induction docetaxel/cisplatin with rhG-CSF and concurrent pulsed docetaxel chemoradiation for stage III non-small cell lung cancer (NSCLC)
Authors: Y. Chen, P. Kishan, T. Smudzin, D. W. Johnstone, T. J. Watson, R. H. Feins
Journal: Journal of Clinical Oncology (2004)

7273 Background: A study was designed to target distant micrometastasis with full-dose chemotherapy (CT) without the delay of local therapy, followed by low-dose CT to sensitize radiation (RT) for gross tumors. The study evaluated the response rate and toxicity of one cycle of full-dose, two-drug CT followed by pulsed low-dose docetaxel (Doc) and concurrent RT for patients (pts) with inoperable stage III NSCLC. Methods: Pts with inoperable stage III NSCLC were eligible. Induction CT consisted of Doc 75mg/m2 and cisplatin 75mg/m2 on day 1, followed by rhG-CSF (150 ∈¼g/m2 s.q. days 2–10). Concurrent chemoradiation started 3–6 weeks after induction CT. Low-dose Doc was12 mg/m2, twice weekly with daily RT. RT dose was 64.8 Gy to gross tumor and 45–57.6 Gy to subclinical disease. All pts enrolled were followed for toxicity and pts who completed therapy were assessed for response. Results: 15 pts were enrolled since 2/2002. All received induction CT except 1 with an anaphylactic reaction to Doc. Eight completed both induction CT and chemoradiation. None of the patients had dose reduction during therapy. Four did not complete therapy due to: 1-Doc intolerance, 1-intercurrent illness, and 2-disease progression during therapy. The response rate was 87.5% (3 CR, 4 PR and 1 SD). Toxicity during induction CT included grade 3 nausea/vomiting (13.3%), grade 3 hypertension (6.7%) along with grade 3 hyperglycemia (6.7%), grade 3 headache (6.7%) and grade 4 fatigue along with grade 3 dyspnea (6.7%). There was no grade 3/4 hematologic toxicity. Toxicities from concurrent chemoradiation included grade 3 esophagitis (50%) and grade 2 pneumonitis (50%). There was no grade 3 pneumonitis or any grade 4 toxicity reported. Conclusions:Induction chemoradiation with one-cycle, full-dose Doc/cisplatin with rhG-CSF followed by concurrent pulsed low-dose Doc resulted in high tumor response rate and acceptable toxicity. Although published MTD of twice-weekly Doc and concurrent RT was 15 mg/m2, 50% of pts in the study experienced grade 3 esophageal toxicity at 12 mg/m2. Twice weekly Doc dose has been reduced to 10 mg/m2 with concurrent RT. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aventis Pharmaceuticals Aventis Pharmaceuticals
Performance of a high-intensity 508-gene circulating-tumor DNA (ctDNA) assay in patients with metastatic breast, lung, and prostate cancer.
Authors: Pedram Razavi, Bob T. Li, Wassim Abida, Alex Aravanis, Byoungsok Jung, Ronglai Shen, Chenlu Hou, Ino De Bruijn, Sante Gnerre, Raymond S. Lim, Dalicia Reales, Tara Maddala, Michael F. Berger, Gregory J. Riely, Howard I. Scher, William F. Novotny, David B. Solit, Mark Lee, Jorge S. Reis-Filho, Jose Baselga
Journal: Journal of Clinical Oncology (2017)

LBA11516 Background: ctDNA assays can noninvasively assess tumor burden and biology by identifying tumor-derived somatic alterations. For broad applicability, including early cancer detection, an unprecedented high-intensity approach (ultra-deep sequencing of plasma cell-free DNA (cfDNA) with broad genomic coverage) is needed to address intra-patient and population-level heterogeneity. We present initial results with this approach in patients (pts) with metastatic breast (BC), non-small cell lung (NSCLC), and castration-resistant prostate cancer (CRPC). Methods: Blood and tissue were prospectively collected w/in 6 wks with no intervening therapy change from pts with de novo or progressive cancer. cfDNA and white blood cell (WBC) genomic DNA from each pt were sequenced with a 508-gene panel (2 Mb; &gt;60,000X raw depth). cfDNA variant calling used molecular barcoding for error correction and filtering for WBC variants. Tissue was sequenced using the MSK-IMPACT assay (410 genes, 1.4 Mb, &gt;500X depth) blinded to plasma/WBC sequencing. Variants were classified as clonal or subclonal based on tumor sequencing in BC and NSCLC. Results: Of 161 eligible pts, 124 (39 BC, 41 NSCLC, and 44 CRPC) were evaluable for concordance. In tissue, 864 variants were detected across the 3 tumor types, with 627 (73%) also detected in plasma: single nucleotide variants/indels - 75%, fusions - 67%, and copy number alterations - 58%. In 90% of pts, at least 1 of the variants detected in tumor tissue was also detected in plasma: BC - 97%, NSCLC - 85%, CRPC - 84%. Most actionable mutations detected in tissue were also detected in plasma (54/71, 76%; SNVs only: 28/31, 90%). A subset of driver mutations (eg. in ESR1, PIK3CA, ERBB2, EGFR) were observed in plasma but not tissue. Clonal variants in tissue were more likely to be detected in plasma than subclonal variants (p&lt;.001). Conclusions: This novel, high-intensity ctDNA assay enabled broad detection of genomic variants in plasma at high rates of concordance with corresponding tumor tissue, providing strong evidence for tumor-derivation of these signals. This study will inform development of a high-intensity sequencing approach for early cancer detection.
Plasma Insulin in Normal Late Pregnancy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Not old
Authors: Fred Charatan
Journal: BMJ (2005)

The role of hyperbaric oxygen in the treatment of necrotising fasciitis remains controversial.Authors have advocated its practice in addition to operative debridement in improving overall survival.The principle behind its use is to increase the tissue oxygen tension in zones of infected hypoxic areas.This prevents extension of the disease and the need for further debridements. 15 Conversely, others have shown no survival benefit. 4Further studies are therefore required before this treatment can be recommended.
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis
Authors: Yuya Kunisaki, Akihiko Nishikimi, Yoshihiko Tanaka, Ryosuke Takii, Mayuko Noda, Ayumi Inayoshi, Ken-ichi Watanabe, Fumiyuki Sanematsu, Takehiko Sasazuki, Takehiko Sasaki, Yoshinori Fukui
Journal: The Journal of Experimental Medicine (2006)
Suicide among men in the highlands of Scotland.
Journal: BMJ (1991)

by heterozygositv for cystic fibrosis would confer biological advantage.The AF508 is most common in white populations in the United Kingdom, United States, and The Netherlands but has a greatly reduced incidence in southern European populationss and in black and Mongoloid populations.Noticeably, fair skinned people are the most susceptible to melanoma and so would benefit the most from the possibly protective heterozygous state.Our finding of an inverse association between being a carrier of AF508 and melanoma was unexpected.It suggests that the presence of a genetic marker (or gene defect) may protect against melanoma.We thank L Meredith for providing some of the data on normal subjects; P Laidler, J A Whittaker, L Hughes, A Jacobs, and P Harper for providing clinical samples and useful discussion; and D C Hughes,
Journal Amer Dietetic Association, Chicago
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcium injection for cardiac arrest.
Journal: BMJ (1967)

Today's Drugs MMICALJOURA further in a number of different psychiatric conditions.Reliable evaluation is not possible at present, because of the quality of previous assessments and the absence of controlled reports in the medical literature. PresentationPericyazine is available as Neulactil, in tablets of 2.5 mg. and 10 mg., as a syrup, and as a solution for injection.The basic N.H.S. cost of 50 tablets of 2.5 mg. is Ss. and of 50 tablets of 10 mg. is 13s.4d.
Composition of Extracts of Airborne Grain Dusts: Lectins and Lymphocyte Mitogens
Authors: Stephen A. Olenchock, Daniel M. Lewis, Judith C. Mull
Journal: Environmental Health Perspectives (1986)

Airborne grain dusts are heterogeneous materials that can elicit acute and chronic respiratory pathophysiology in exposed workers. Previous characterizations of the dusts include the identification of viable microbial contaminants, mycotoxins, and endotoxins. We provide information on the lectin-like activity of grain dust extracts and its possible biological relationship. Hemagglutination of erythrocytes and immunochemical modulation by antibody to specific lectins showed the presence of these substances in extracts of airborne dusts from barley, corn, and rye. Proliferation of normal rat splenic lymphocytes in vitro provided evidence for direct biological effects on the cells of the immune system. These data expand the knowledge of the composition of grain dusts (extracts), and suggest possible mechanisms that may contribute to respiratory disease in grain workers.
Enzyme Relaxes Cortex of Mitotic Cells
Journal: Cancer Discovery (2015)

At the end of mitosis, the stiff actomyosin cortex at a cell's poles has to soften so that the cell can elongate and divide. The enzyme PP1, which sits on the kinetochores during metaphase and anaphase, spurs the polar cortex to relax. Polar relaxation is particularly important for cancer cells, and inhibiting it might rein in their division.
Wilson's disease in The Merck Manual: corrections
Authors: R. Berkow
Journal: JAMA (1988)

<h3>To the Editor.</h3> —Triplett and associates<sup>1</sup>have made important observations about the relationship of lupus anticoagulants, phospholipid antibodies, and clinical disorders. However, they stated that 8% of their patients had a history of spontaneous abortion. Although eight of the 100 patients had a history of recurrent abortions, there were only 50 women in the study. It would be more appropriate to state that eight (16%) of 50 women had a history of recurrent abortion. The 95% confidence intervals for this observation are 7.17% to 29.11%. Recurrent spontaneous abortion, the loss of three or more pregnancies before 20 weeks' gestation, occurs in an estimated 0.4% to 0.8% of women. Spontaneous abortion is clinically recognized in 15% to 20% of pregnancies.<sup>2</sup>The association of phospholipid antibodies and recurrent spontaneous abortion should be emphasized. The causative role, if any exists, remains to be elucidated.
GERMANY.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: K. JOHNSON
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Women at High Risk to Breast Cancer. Basil A. Stoll, ed. Dordrecht,The Netherlands: KluwerAcademic Publishers, 1989, 133 pp. $53. KAREN JOHNSON KAREN JOHNSON Vincent T. Lombardi Cancer Center, Georgetown University School of, MedicinePodium Level 3800 Reservoir Rd., N.W., Washington DC 20007 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 24, 20 December 1989, Pages 1922–1923, https://doi.org/10.1093/jnci/81.24.1922-a Published: 20 December 1989
Change of Telephone Number for Reporting of Malaria Cases
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ACTION OF THE X-RAYS ON LEUKEMIC BLOOD.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE MEDICINE OF THE FUTURE.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
List no. 92. New names
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SURGERY OF THE LUNG.
Authors: J. B. MURPHY
Journal: JAMA (1898)

Carron proposed to compress the lung over tubercular cavities with the hope that the collapse of the lung would be followed by an obliteration of the cavities. MacEwen favors resection of the ribs to allow the contraction of the chest over small cavities and the drainage and even curettement of large ones. Coromilas, Greece, favors pneumotomy and early surgical interference in tubercular processes. If the adhesions be firm and the parietal and visceral layers can not be separated, then the parietal layer should be separated from its costal attachments and allowed to sink in with the lung, or it should be held compressed by a tampon beneath the flap for forty-eight to seventy-two hours. Will found that in thirty-six cases of tuberculosis in the early stage, thirty-two admitted of complete collapse of the lung and four only partial. If on examination it be fourni