tbuckley/cabot-search huggingface dataset:
Reply†
Authors: Ina Bergheim, Astrid Spruss
Journal: Hepatology (2010)

We thank Johnston and colleagues for their comments and this opportunity to discuss the questions regarding our recent investigation on the role of Toll-like receptor 4 (TLR4) in the development of fructose-induced hepatic steatosis in mice.1 Our answer will address their main points: First, as pointed out by Johnston and colleagues, we found in an earlier study that chronic intake of different sugars can affect dietary pattern and caloric intake and subsequently weight gain in a specific manner in C57BL/6J mice.2 In these studies, we found that fluid intake of mice varies according to the type of sugar offered in the drinking solution (glucose > sucrose > fructose > water). Contrary to this previous study, mice in the present study were either fed water or fructose solution. In the present study, we determined fluid intake of mice to ascertain that mice had a similar exposure to fructose (data not shown before). Indeed, despite the differences in absolute weight gain, both C3H/HouJ and C3H/HeJ mice consumed on average ∼0.30 mL of 30% fructose solution/day and per gram body weight, amounting to an average fructose intake of ∼0.09 g/day and per gram body weight. In line with the findings of our study, Tsukumo et al.,3 who fed C3H/HeJ mice a high-fat diet for 2-8 months, also reported that the TLR4 mutant mice gained less weight in comparison to wild-type mice, despite no differences in total food intake. Second, it was also pointed out by Johnston and colleagues that when reanalyzing our data on hepatic triglyceride content, they only found a relative influence of ∼10% after the loss of a functional TLR4. We reanalyzed the data according to the suggestions of Dr. Johnston and his colleagues (data are shown in Fig. 1). When analyses of triglyceride data were performed as per their suggestions, triglyceride levels were 3.3-fold higher in livers of fructose-fed wild-type mice in comparison to wild-type water-fed controls, whereas in livers of TLR4 mutant mice, triglyceride levels were only 2.3-fold higher than in livers of the TLR4 mutant mice fed water, resulting in a difference between fructose-fed wild-type and TLR4 mutant mice of 30%. These results are in accordance with our findings for portal endotxin concentration and MyD88 concentration in the liver, shown in figures 2 and 3 of our article. Expression of α-SMA was detected in (A) Kunming mouse liver and (B) CCl4-induced liver by immunohistochemistry. Sections were incubated with antibody against α-SMA (Abcam, Cambridge, MA; diluted 1:50) followed by visualization with the Histostain-Plus Kit (Invitrogen, Carlsbad, CA) after treatment with 3,3-diaminobenzidine and counterstain with hematoxylin (magnification = ×1000). Ina Bergheim*, Astrid Spruss*, * Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany.
Report of the Committee on Bed-Bug Infestation, 1935-1940
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Air-rinsing after dialysis. A mode of transmission of hepatitis virus
Authors: F. M. LaForce
Journal: JAMA (1975)

During a recent outbreak of hepatitis B among patients receiving dialysis, geographic and temporal distribution of cases in the absence of exposure to blood products suggested patient-to-patient transmission. The patients who contracted hepatitis used Kiil dialyzers with a single-pass dialysate system, while patients who used hollow-fiber dialyzers appeared to be protected. Blood was returned to patients after Kiil dialysis by the air-rinse technique with use of a nonsterile plastic tube attached to a manometer bulb. Laboratory experiments demonstrated that<i>Staphylococcus aureus</i>and poliovirus became widely distributed throughout the Kiil dialyzer when introduced during the rinse phase by contaminating the air-rinse tubing. (<i>JAMA</i>233:331-335, 1975)
Editorial Board
Authors: Joël Savard, Feng Chen, Basil Nyaku, Janeth Adove-Nucaza, Y Hayashizaki, S Henikoff, J Hodgkin, H Horvitz, Usa Cambridge, M Hurst, E Koonin, E Meyerowitz, S Moreno, J Smith, M Takeichi, Japan Kobe, Guido Barbujani, Vincenza Colonna, Amaury De Montaigu, Réka Tóth, George Coupland, Pavan Ramdya, Richard Benton, Norman Johnson, Alberto De La Fuente
Journal: Trends in Genetics (2010)
Belimumab for systemic lupus erythematosus
Authors: Laurent Chiche, Noémie Jourde, Julien Mancini
Journal: The Lancet (2011)

Sandra Navarra and colleagues1 report the results of a successful trial of belimumab biotherapy for systemic lupus erythematosus (SLE). Their methods are robust and use a new composite index custom-designed from the results of a negative preliminary study,2 but the conclusions with regard to the place of this drug in clinical practice should be tempered.
The Sudden Murderer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Child medicine grows up
Authors: K. Glasbrenner
Journal: JAMA (1986)

On May 1, 1972, pediatrician John Morgan helped bring Mary Jo into the world. Since then, he has treated her measles, sewn up her cut knee, and watched her grow and develop from year to year. She was always the sweet little girl who read the tattered issues of Children's Digest cover-to-cover while sitting in the waiting room. She wore her waist-length hair in braids, lived in overalls and tennis shoes, and spoke of nothing but horseback riding. But today, as he passes the waiting room, he sees her and is surprised. An issue of Glamour has replaced the Children's Digest. Her hair is lopped off at the shoulder, her face touched with makeup, and she wears high heels and a drop-waist dress. She has undergone metamorphosis from a little girl into a teenager. As pediatricians begin to see their babies grow up, suddenly they are faced with problems of
Data from the third dose cohort of an ongoing study with ADP-A2AFP SPEAR T cells
Authors: Bruno Sangro, Mitesh J. Borad, Petr F. Hausner, Tim Meyer, Amit Mahipal, Lipika Goyal, Matthew J. Frigault, Debashis Sarker, Lynn G. Feun, Kit Wong, Anthony El-Khoureiry, Richard Finn, Ahmed Kaseb, Benjamin R. Tan, Fiona Thistlethwaite, Bassel El-Rayes, Jordi Bruix, Joana Senra, Trupti Trivedi, Paula Fracasso, Svetlana Fayngerts, Erica Elefant, Jennifer Sampson, Swethajit Biswas, Elliot Norry
Journal: Journal of Hepatology (2020)
Update: Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Men with Possible Zika Virus Exposure — United States, August 2018
Authors: Kara D. Polen, Suzanne M. Gilboa, Susan Hills, Titilope Oduyebo, Katrin S. Kohl, John T. Brooks, Alys Adamski, Regina M. Simeone, Allison T. Walker, Dmitry M. Kissin, Lyle R. Petersen, Margaret A. Honein, Dana Meaney-Delman
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Zika virus infection can occur as a result of mosquitoborne or sexual transmission of the virus. Infection during pregnancy is a cause of fetal brain abnormalities and other serious birth defects (1,2). CDC has updated the interim guidance for men with possible Zika virus exposure who 1) are planning to conceive with their partner, or 2) want to prevent sexual transmission of Zika virus at any time (3). CDC now recommends that men with possible Zika virus exposure who are planning to conceive with their partner wait for at least 3 months after symptom onset (if symptomatic) or their last possible Zika virus exposure (if asymptomatic) before engaging in unprotected sex. CDC now also recommends that for couples who are not trying to conceive, men can consider using condoms or abstaining from sex for at least 3 months after symptom onset (if symptomatic) or their last possible Zika virus exposure (if asymptomatic) to minimize their risk for sexual transmission of Zika virus. All other guidance for Zika virus remains unchanged. The definition of possible Zika virus exposure remains unchanged and includes travel to or residence in an area with risk for Zika virus transmission (https://wwwnc.cdc.gov/travel/page/world-map-areas-with-zika) or sex without a condom with a partner who traveled to or lives in an area with risk for Zika virus transmission. CDC will continue to update recommendations as new information becomes available.
DOMESTIC CORRESPONDENCE.
Authors: E. L. Boothby
Journal: JAMA (1885)

Hammond, Wis., February 6, 1885. <h3>Editor Journal American Medical Association:</h3><h3>Dear Sir</h3> —In a case of labor occurring in my practice, Saturday, January 31, 1885, the following facts seem sufficiently interesting for record: 1st. The age of the patient being 44 years, October 17, 1884, this was her first pregnancy; delivery by forceps, slight perineal rupture, patient doing finely so far. She is a Norwegian, and here is the second interesting fact: Her first husband, with whom she lived nearly twenty years, died some two and a half years since. He was a leper, and the first and only case of leprosy I ever saw, and, so far as I am aware, the second case ever known in the State, the first authenticated case being under care of Dr. Samuel C. Johnson, of Hudson, Wis., now a member of the State Board of Health. There<i>may have been other cases</i>
Longevity requires policy revolution
Authors: C. Marwick
Journal: JAMA (1995)

THE INCREASING longevity of people in the industrialized world has been termed a revolution. To meet the challenges it poses will require another revolution, a drastic change in social policy, says Robert N. Butler, MD, an internationally recognized authority on aging. Butler, chair of the Henry L. Schwartz Department of Geriatrics and Adult Development at Mt Sinai School of Medicine, New York, NY, spoke at a conference on "Longevity and the Media," which was cosponsored by the International Leadership Center on Longevity and Society of Mt Sinai Hospital and the Columbia University Graduate School of Journalism. Its intent was to alert journalists to issues involved in aging from the perspective of the individual, the entire population, and the development of public policy. "The topic has become a major issue in public debate, and there is a feeling that there are large cross-cutting problems and that the press, in its coverage
Adaptor Protein Lnk Binds to and Inhibits Normal and Leukemic FLT3
Authors: Dechen Lin, Tong Yin, Maya koren-Michowitz, Ling-Wen Ding, Saskia Gueller, Sigal Gery, Takayuki Tabayashi, Ulla Bergholz, Julhash Kazi, Lars Rönnstrand, Carol Stocking, Phillip Koeffler
Journal: Blood (2012)
Somatization and medicalization in the era of managed care
Authors: A. J. Barsky
Journal: JAMA (1995)

Somatization, the reporting of somatic symptoms that have no pathophysiological explanation, appears to be increasing as sociocultural currents reduce the public's tolerance of mild symptoms and benign infirmities and lower the threshold for seeking medical attention for such complaints. These trends coincide with a progressive medicalization of physical distress in which uncomfortable bodily states and isolated symptoms are reclassified as diseases for which medical treatment is sought. Somatization and medicalization are likely to become more problematic in the era of managed care. Under capitation, providers will have greater incentives to reduce utilization, and somatizing patients may feel forced to express their "dis-ease" in more urgent and exaggerated terms in order to gain access to the physician. In addition, prepaid subscribers will suffer little financial disincentive to seek medical attention for relatively minor complaints; therefore, they are likely to increase the demand for physician consultation. This situation suggests an urgent need to improve the management of somatizing patients. Innovative consultative, behavioral, and educational interventions are now available. In addition, medical professionals should greet the process of medicalization with considerable caution and educate the public more about the normative presence of symptoms and bodily distress in healthy people. Additional research is needed into somatization and its relationship to the demand for medical care. In an era of managed care, increased attention should be devoted to understanding and controlling the demand for care, a large portion of which is symptom driven. (<i>JAMA</i>. 1995;274:1931-1934)
Highlights
Journal: JAMA Surgery (2018)

Timing of Attrition in Surgical Residency 511The timing of general surgery residents' dropping out of training has not been prospectively evaluated.Yeo et al analyzed data from a national cohort of 836 surgical residents from 2007 to 2016.For all residents, attrition was highest in the first year of training.However, attrition continued into senior years of training for women and individuals of Hispanic ethnicity.
A Trichomonas species in a mixed microbial meningitis
Authors: H. Masur
Journal: JAMA (1976)

TRICHOMONADS are rarely demonstrated outside of the gastrointestinal or lower genitourinary tracts.<sup>1-3</sup>To our knowledge, the following case is the first report of a<i>Trichomonas</i>species isolated from the cerebrospinal fluid in a patient with meningitis. <h3>Report of a Case</h3> A 69-year-old man, formerly in good health, noted dysphagia in June 1975. In August 1975, he was referred to Memorial Sloan-Kettering Cancer Center, where findings from a physical examination were unremarkable. Laboratory examination included a hematocrit reading of 39% and a leukocyte count of 6,300/cu mm. Other laboratory tests were normal. Endoscopy showed an epidermoid carcinoma of the distal third of the esophagus. After a total dose of 2,000 rads of cobalt 60 to the anterior and posterior distal esophagus, the patient underwent exploration by thoracoabdominal approach on Aug 12. An infiltrating epidermoid carcinoma was resected with creation of an esophagogastrostomy. A splenectomy and distal pancreatectomy were also performed.
Neonatology
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcohol Amnesia
Authors: Ralph S. Ryback
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Recent research on alcohol and memory, utilizing the threefold classification of memory function,<sup>1</sup>indicates that there are two forms of alcohol amnesia.<sup>2-4</sup>In the first form the patient or subject can recall what occurred under the influence of alcohol only if he is again placed in the same intoxicated state, or if the physician describes and discusses what occurred. The subject may then respond, "Yes, now I remember it," and go on to add more details spontaneously.<sup>2</sup>This form of alcohol amnesia is called state-dependent learning, or the idea that information learned under the effects of alcohol can best be remembered in the same drug state and is poorly or not remembered in the nondrug state. This form of alcohol amnesia has been demonstrated in animals<sup>4-6</sup>and man.<sup>7,8</sup>Interestingly, the blood alcohol concentrations necessary to produce state-dependent learning in man<sup>7,8</sup>have
Refinancing GME
Authors: Mike Mitka
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lung Opacification
Authors: Wan-Yee Teo, Robin Y. Dulman, Tuyethoa Vinh
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary Drug Resistance In Tuberculosis
Authors: Sol Katz
Journal: JAMA (1970)

<h3>To the Editor:—</h3> It is apparent that Doctors Tizes and Zaki have strong feelings on the problem of primary drug resistance in tuberculosis. Unfortunately, they state their criticisms of the opinions expressed in the editorial on this topic with use of some of the same arguments to which they object. All would agree with them that one cannot generalize on the matter of drug resistance but that is just what they do! Some surveys encompass national sampling, others deal with states, districts, towns, or special groups. For example, a prevalence of 40% of drug-resistant strains isolated from the inhabitants of skid row by Chaves and others (<i>Amer Rev Resp Dis</i>,<b>84</b>:647, 1961) is not representative of New York city any more than the critics' finding of a "rise in infections with strains resistant to isoniazid from 6.5% in 1960 to 17.3% in 1964." Hobby and her associates (<i>Amer Rev</i>
Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
Authors: Daniel R. Goldstein, Bethany M. Tesar, Shizuo Akira, Fadi G. Lakkis
Journal: Journal of Clinical Investigation (2003)

The Toll-like receptors (TLRs) are recently discovered germline-encoded receptors on APCs that are critically important in innate immune recognition of microbial pathogens. However, their role in solid-organ transplantation is unknown. To explore this role, we employed a skin allograft model using mice with targeted deletion of the universal TLR signal adaptor protein, MyD88. We report that minor antigen–mismatched (HY-mismatched) allograft rejection cannot occur in the absence of MyD88 signaling. Furthermore, we show that the inability to reject these allografts results from a reduced number of mature DCs in draining lymph nodes, leading to impaired generation of anti–graft-reactive T cells and impaired Th1 immunity. Hence, this work demonstrates that TLRs can be activated in a transplant setting and not solely by infections. These results link innate immunity to the initiation of the adaptive alloimmune response.
Dialysis Elbow
Authors: Cosme Cruz
Journal: JAMA (1978)

<h3>To the Editor.—</h3> We appreciate comments by Don E. Cheatum, MD (238:1813,1977), on our report on "Dialysis Elbow: Olecranon Bursitis From Long-Term Hemodialysis" (238:243, 1977). However, we would like to emphasize the clear distinction between calcific tendinitis, which is one of many forms of extraosseous calcification and results from abnormal mineral metabolism in uremia, and the dialysis elbow, which results from sustained pressure on these sites and possibly is complicated by microhemorrhages related to systemic heparinization during the dialysis procedure. The latter is a complication of chronic hemodialysis, which, to our knowledge, has not been previously reported and in no way is associated with crystal deposition. Both references cited by Dr Cheatum describe patients with articular problems related to soft-tissue calcification.