tbuckley/cabot-search huggingface dataset:
WHEN THE AT-RISK DO NOT DEVELOP HEART FAILURE: UNDERSTANDING POSITIVE DEVIANCE AMONG POSTMENOPAUSAL AFRICAN-AMERICAN AND HISPANIC WOMEN
Authors: Khadijah Breathett, Lindsay Kohler, Charles Eaton, Nora Franceschini, Lorena Garcia, Liviu Klein, Lisa Warsinger Martin, Heather Ochs-Balcom, Aladdin Shadyab, Crystal Cene
Journal: Journal of the American College of Cardiology (2020)
Acid Mine Drainage and Subsidence: Effects of Increased Coal Utilization
Authors: Ronald D. Hill, Edward R. Bates
Journal: Environmental Health Perspectives (1979)

The increases above 1975 levels for acid mine drainage and subsidence for the years 1985 and 2000 based on projections of current mining trends and the National Energy Plan are presented. No increases are projected for acid mine drainage from surface mines or waste since enforcement under present laws should control this problem. The increase in acid mine drainage from underground mines is projected to be 16 percent by 1985 and 10 percent by 2000. The smaller increase in 2000 over 1985 reflects the impact of the PL 95-87 abandoned mine program. Mine subsidence is projected to increase by 34 and 115 percent respectively for 1985 and 2000. This estimate assumes that subsidence will parallel the rate of underground coal production and that no new subsidence control measures are adopted to mitigate subsidence occurrence.
Five-Year Follow-Up of the Medicine, Angioplasty, or Surgery Study (MASS)
Authors: Whady A. Hueb, Paulo Rogério Soares, Sérgio Almeida de Oliveira, Shiguemituzo Ariê, Rita Helena A. Cardoso, Dalia Ballas Wajsbrot, Luiz A. M. Cesar, Adib D. Jatene, José Antonio F. Ramires
Journal: Circulation (1999)

Background —Although coronary angioplasty and myocardial bypass surgery are routinely used, there is no conclusive evidence that these interventional methods offer greater benefit than medical therapy alone. This study is intended to evaluate, in a prospective, randomized, and comparative analysis, the benefit of the 3 current therapeutic strategies for patients with stable angina and single proximal left anterior descending coronary artery stenosis. Methods and Results —In a single institution, 214 patients with stable angina, normal ventricular function, and severe proximal stenosis (&gt;80%) on the left anterior descending artery were selected for the study. After random assignment, 70 patients were referred to surgical treatment, 72 to angioplasty, and 72 to medical treatment. The primary end points were the occurrence of acute myocardial infarction or death and presence of refractory angina. After a 5-year follow-up, these combined events were reported in only 6 patients referred to surgery as compared with 29 patients treated with angioplasty and 17 patients who only received medical treatment ( P =0.001). However, no differences were noted in relation to the occurrence of cardiac-related death in the 3 treatment groups ( P =0.622). No patient assigned to surgery needed repeat operation, whereas 8 patients assigned to angioplasty and 8 patients assigned to medical treatment required surgical bypass after the initial random assignment. Surgery and angioplasty reduced anginal symptoms and stress-induced ischemia considerably. However, all 3 treatments effectively improved limiting angina. Conclusions —Bypass surgery for single-vessel coronary artery disease is associated with a lower incidence of medium-term and long-term events as well as fewer anginal symptoms than that found in the patients who underwent angioplasty or medical therapy. In this study, coronary angioplasty was only superior to medical strategies in relation to the anginal status. However, the 3 treatment regimens yielded a similar incidence of acute myocardial infarction and death. Such information should be useful when choosing the best therapeutic option for similar patients.
Disorders of the Blood: Diagnosis, Pathology, Treatment and Technique
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats</i>: Percentage* of Adults Aged ≥18 Years Who Walked ≥10 Minutes as a Method of Transportation,† by Location of Residence§ — National Health Interview Survey, United States, 2005, 2010, and 2015¶
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Overall, the percentage of adults aged ≥18 years that walked as a method of transportation increased from 29.4% in 2005 to 32.5% in 2015. A similar pattern was observed for adults residing in metropolitan locations (31.2% to 34.1%) but there was no change for those residing in nonmetropolitan locations (22.4% to 22.2%). Regardless of year, adults residing in metropolitan locations were more likely to have walked as a method of transportation than were adults residing in nonmetropolitan locations.
Tumor cells in the blood may indicate poor prognosis in early breast cancer
Journal: JNCI Journal of the National Cancer Institute (2014)

Tumor cells in the blood may indicate poor prognosis in early breast cancerTumor cells in bone marrow of early breast cancer patients predict a higher risk of relapse as well as poorer survival, but bone marrow biopsy is an invasive and painful procedure.Now, it may be possible to identify tumor cells in a routine blood sample and use them as prognostic markers, according to a study published May 15 in the Journal of the National Cancer Institute.To assess the prognostic value of circulating tumor cells (CTCs) in patients with early breast cancer, Brigitte Rack, M.D., of the Department of Gynecology and Obstetrics, Klinikum Innenstadt, Ludwig-Maximilians-
Preoperative Chemotherapy Followed by Surgery Compared With Primary Surgery in Resectable Stage I (Except T1N0), II, and IIIa Non–Small-Cell Lung Cancer
Authors: Alain Depierre, Bernard Milleron, Denis Moro-Sibilot, Sylvie Chevret, Elisabeth Quoix, Bernard Lebeau, Denis Braun, Jean-Luc Breton, Etienne Lemarié, Sylvie Gouva, Nadine Paillot, Jeanne-Marie Bréchot, Henri Janicot, François-Xavier Lebas, Philippe Terrioux, Jean Clavier, Pascal Foucher, Michel Monchâtre, Daniel Coëtmeur, Marie-Claude Level, Pascal Leclerc, François Blanchon, Jean-Michel Rodier, Luc Thiberville, Anne Villeneuve, Virginie Westeel, Claude Chastang
Journal: Journal of Clinical Oncology (2002)

To evaluate whether preoperative chemotherapy (PCT) could improve survival in resectable stage I (except T1N0), II, and IIIA non-small-cell lung cancer (NSCLC).A randomized trial compared PCT to primary surgery (PRS). PCT consisted of two cycles of mitomycin (6 mg/m(2), day 1), ifosfamide (1.5 g/m(2), days 1 to 3) and cisplatin (30 mg/m(2), days 1 to 3), and two additional postoperative cycles for responding patients. In both arms, patients with pT3 or pN2 disease received thoracic radiotherapy.Three hundred fifty-five eligible patients were randomized. Overall response to PCT was 64%. There were two preoperative toxic deaths. Postoperative mortality was 6.7% in the PCT arm and 4.5% in the PRS arm (P =.38). Median survival was 37 months (95% confidence interval [CI], 26.7 to 48.3) for PCT and 26.0 months (95% CI, 19.8 to 33.6) for PRS (P =.15). Survival differences between both arms increased from 3.8% (95% CI, 1.3% to 25.1%) at 1 year to 8.6% (95% CI, 2.64% to 24.4%) at 4 years. A quantitative interaction between N status and treatment was observed, with benefit confined to N0 to N1 disease (relative risk [RR], 0.68; 95% CI, 0.49 to 0.96; P =.027). After a nonsignificant excess of deaths during treatment, the effect of PCT was significantly favorable on survival (RR, 0.74; 95% CI, 0.56 to 0.99; P =.044). Disease-free survival time was significantly longer in the PCT arm (P =.033).Although impressive differences in median, 3-year, and 4-year survival were observed, they were not statistically significant, except for stage I and II disease.
Letter: Abortion (amendment) bill.
Authors: J Barrowman, A Bennet, P Hillenbrand, K Rolles, D Pollock, J Wright
Journal: BMJ (1975)

have been both surprised by the low plasma levels of prostaglandinlike activity reported (pg/1) and jealous of the sensitivity of our assay.The values before and after surgery were 1 million times higher and should have read 5-4 and 0 5 ng prostaglandin E2 equivalents/ml respectively.
Failure of talc pleurodesis is associated with increased pleural fibrinolysis.
Authors: F Rodriguez-Panadero, A Segado, J Martin Juan, R Ayerbe, I Torres Garcia, J Castillo
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Diffuse pleural inflammation and fibrin deposition following the instillation of the sclerosing agent is considered necessary for a successful pleural symphysis. We hypothesized that an impairment in fibrin formation or an increased endopleural fibrinolysis would lead to failure of pleurodesis. To investigate changes in the pleural coagulation/fibrinolysis balance, we studied 75 consecutive patients who underwent thoracoscopy. Fifty-four of these patients with malignant pleural effusions and four with a benign recurrent effusion underwent thoracoscopic talc pleurodesis. Another four patients with malignancy and 13 with benign effusions had no talc poudrage performed and were included as a control group. Serial determinations of thrombin-antithrombin III complex (TAT), plasminogen activator inhibitor (PAI), and D-dimer were made in pleural fluid samples taken at the beginning of thoracoscopy (baseline), immediately after thoracoscopic biopsies had been done (postbiopsy), 3 h after thoracoscopy--either with talc poudrage or without--and 24 and 48 h after the procedure, as well as in cases of recurrence of effusions (farline). Successful pleurodesis was obtained in 42 of 52 patients who could be evaluated (81%), and failure was seen in 10. Strong activation of coagulation and production of PAI was observed in all groups, including the control (no talc) group. Fibrinolytic activity (as expressed by D-dimer levels) showed a clear decline 24 h after talc poudrage in patients with a good outcome of pleurodesis, as oppossed to those with bad results and to the control group, and returned to the baseline by 15 d. We conclude that increased pleural fibrinolytic activity is associated with failure of pleurodesis, despite significant inhibitory activity of PAI in all groups.
Endotrophin, a hormone derived from type VI collagen, activates fibroblasts and drives fibrosis in the liver, lung, kidney, and heart
Authors: Morten Karsdal, Mette Juul Nielsen, Jannie MB Sand, Alexander Lynge, Daniel Guldager Kring Rasmussen, Federica Genovese, Anne Christine Bay-Jensen, Nicholas Willumsen, Diana Leeming
Journal: Journal of Hepatology (2020)
Antigen Analogs/MHC Complexes as Specific T Cell Receptor Antagonists
Authors: A. Sette
Journal: Annual Review of Immunology (1994)

Recent studies demonstrated that antigen analogs can act as powerful and specific inhibitors of T cell activation, leading to the formulation of the concept that antigen analog/MHC complexes may act as antagonists of the T cell receptor (TCR). TCR antagonism appears to be associated with engagement of the TCR below a crucial affinity threshold necessary for full T cell activation. Studies addressing the molecular mechanism of this effect suggest that TCR antagonists could act by interfering with membrane-related events (such as proper receptor clustering) that might precede intracellular signaling. Discovery of the TCR antagonism phenomenon also suggested a possible rational approach to antigen-specific immunointervention in allergies and autoimmune diseases. The feasibility of such an approach is now being actively investigated. Finally, TCR antagonist peptides may provide a useful tool to probe TCR-peptide/MHC interactions involved in the process of thymic education.
Measurement Issues in Environmental Epidemiology
Authors: Maureen Hatch, Duncan Thomas
Journal: Environmental Health Perspectives (1993)

This paper deals with the area of environmental epidemiology involving measurement of exposure and dose, health outcomes, and important con- founding and modifying variables (including genotype and psychosocial factors).Using examples, we illustrate strategies for increasing the accuracy of exposure and dose measurement that include dosimetry algorithms, pharmacokinetic models, biologic markers, and use of multiple measures.Some limitations of these methods are described and suggestions are made about where formal evaluation might be helpful.We go on to discuss methods for assessing the inaccuracies in exposure or dose measurements, including sensitivity analysis and validation studies.In relation to mea- surement of health outcomes, we discuss some definitional issues and cover, among other topics, biologic effect markers and other early indicators of disease.Because measurement error in covariates is also important, we consider the problems in measurement of common confounders and effect modifiers.Finally, we cite some general methodologic research needs.
The FGF19 analogue aldafermin improves non-invasive tests in patients with non-alcoholic steatohepatitis
Authors: Marno Ryan, Stuart Roberts, Manal Abdelmalek, James F. Trotter, Angelo Paredes, Guy Neff, Andrew Yan, Alex DePaoli, Lei Ling, Hsiao Lieu, Stephen Harrison
Journal: Journal of Hepatology (2020)
169P IMbrave150: Management of adverse events of special interest (AESIs) for atezolizumab (atezo) and bevacizumab (bev) in unresectable HCC
Authors: M. Kudo, M. Ikeda, A.X. Zhu, S. Qin, T-Y. Kim, H.Y. Lim, V. Breder, P. Merle, A. Kaseb, D. Li, N. Ma, M. Villalobos, S. Stanzel, V.E. Gaillard, D-Z. Xu, S. Hernandez, A-L. Cheng, R.S. Finn, P.R. Galle, M. Ducreux
Journal: Annals of Oncology (2020)
Clinical Pharmacol &amp; Therapeutics, St. Louis
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Direct Method of Artificial Respiration for the Treatment of the Drowned, Still-Birth, Etc
Authors: B. Howard
Journal: BMJ (1881)

which differed slightly from those described by Owen and Reinhardt, and which Professor Flower named Pseudorca mewridionalis; but, since more skulls of the same species have been obtained, it is evident that thev all belong to the one species, Psetzedorca corassidens.A smaller, but closely allied form, is the Orcella, found in some of the rivers of India and the Bay of Bengal.The Beluga, or white whale, is a purely arctic species, distinguished by being of a whitish tallow colour, and having no dorsal fin.The
Hemodynamic Effects of Quantitatively Varied Experimental Mitral Regurgitation
Authors: EUGENE BRAUNWALD, GEORGE H. WELCH, STANLEY J. SARNOFF
Journal: Circulation Research (1957)

Mitral regurgitation was produced in the open-chest dog by permitting blood to flow from left ventricle through a flow meter into the left atrium during systole. The hemodynamic effects of known amounts of regurgitation were studied. Two liters per minute of mitral regurgitant flow had relatively little effect on effective cardiac output, aortic pressure, left atrial pressure and on the left ventricular function curve.
Relation of Osteopenia to Glucocorticoid Replacement Therapy in Addison Disease
Authors: J.P Devogelaer
Journal: Annals of Internal Medicine (1994)

Letters1 August 1994Relation of Osteopenia to Glucocorticoid Replacement Therapy in Addison DiseaseJ.P Devogelaer, MD, J. Crabbe, MD, and C. Nagant Deuxchaisnes, MDJ.P Devogelaer, MDSearch for more papers by this author, J. Crabbe, MDSearch for more papers by this author, and C. Nagant Deuxchaisnes, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-3-199408010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The interesting study by Zelissen and colleagues [1] on bone mineral density in patients with Addison disease seems to confirm our published findings, that it is the lack of adrenal androgens in patients with Addison disease rather than the glucocorticoid replacement therapy that is responsible for low bone mineral density [2, 3]. Thus, the title of their article is misleading. Furthermore, their Table 1 is somewhat confusing, particularly because of the failure to distinguish postmenopausal from premenopausal women. In our experience [2, 3] only postmenopausal women with Addison disease have a decreased bone mineral density both at ...References1. Zelissen PM, Croughs RJ, van Rijk PP, Raymakers JA. Effect of glucocorticoid replacement therapy on bone mineral density in patients with Addison disease. Ann Intern Med. 1994; 120:207-10. Google Scholar2. Devogelaer JP, Crabbe J, Nagant de Deuxchaisnes C. Bone mineral density in Addison's disease: evidence for an effect of adrenal androgens on bone mass. Br Med J. 1987; 294:798-800. Google Scholar3. Devogelaer JP, Crabbe J, Nagant de Deuxchaisnes C. Trabecular bone mass in postmenopausal addisonians: a clue to postmenopausal osteoporosis? In: Christiansen C, Johansen JS, Riis BJ, eds. Osteoporosis 1987. Viborg: Norhaven; 1987:623-4. Google Scholar4. Winter JS, Couch RM. Modern medical therapy of congenital adrenal hyperplasia. Ann N Y Acad Sci. 1985; 458:165-73. Google Scholar5. Migeon CJ. Diagnosis and treatment of adrenogenital disorders. In: DeGroot LJ, ed. Endocrinology. 2d ed. Philadelphia: W.B. Saunders; 1989:1676-704. Google Scholar Author, Article, and Disclosure InformationAuthors: J.P Devogelaer, MD; J. Crabbe, MD; C. Nagant Deuxchaisnes, MDAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1994Volume 121, Issue 3Page: 235-237KeywordsAndrogensBoneBone densityDiabetes mellitusEstrogensGlucocorticoid therapyHormonal therapyHormone replacement therapyOsteopeniaSpine ePublished: 15 August 2000 Issue Published: 1 August 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Refraction Correlated with Optics and Physiological Optics and Motility Limited to Heterophoria
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“Sleep apnoea is associated with major cardiac events in peripheral arterial disease.” Karri T. Utriainen, Juhani K. Airaksinen, Olli Polo, Ruut Laitio, Mikko J. Pietilä, Harry Scheinin, Tero Vahlberg, Kari A. Leino, Erkki S. Kentala, Jouko R. Jalonen, Harri Hakovirta, Riitta Parkkola, Sami Virtanen and Timo T. Laitio. Eur Respir J 2014; 43: 1652−1660.
Journal: European Respiratory Journal (2018)
Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): Preliminary results from KEYNOTE-012 expansion cohort.
Authors: Tanguy Y. Seiwert, Robert I. Haddad, Shilpa Gupta, Ranee Mehra, Makoto Tahara, Raanan Berger, Se-Hoon Lee, Barbara Burtness, Dung T. Le, Karl Heath, Amy Blum, Marisa Dolled-Filhart, Kenneth Emancipator, Kumudu Pathiraja, Jonathan D. Cheng, Laura Q. Chow
Journal: Journal of Clinical Oncology (2015)

LBA6008 The full, final text of this abstract will be available at abstracts.asco.org at 2:00 PM (EDT) on Friday, May 29, 2015, and in the Annual Meeting Proceedings online supplement to the June 20, 2015, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Monday edition of ASCO Daily News.