tbuckley/cabot-search huggingface dataset:
ON THE USE OF CUBEBS IN THE TREATMENT OF GONORRHOEA
Authors: H. B. Norman
Journal: BMJ (1856)

co poultices to the incision, and other parts which had gien way, and looked unhealthy.December 14th.The report to-day is that he is better; the.discharge is free.He takes his nourishment-beef- tea and beer.December 15th.He is not so well; the discharge is not so free.He passes his water pretty well.The minor details as to prescriptions are of no particular importance.December 20th, and up to 25th (Christmas Day).Going on well; sloughs separated; healthy granulations spring- ing up, etc. January 5th.Now, as Mr. Lawrence observed, we tur over a new leaf in the history.This is the twenty-fourth or twenty-fifth day since his admission.and the report states, " He experiences symptoms of stiffness of the jaws, tetanus, and aching pains; the abdominal muscles also are rigid as a board; the bowels are constipated; the parts in the perinsum are nearly healed."Mr. Lawrence ordered him, for this tetanic rigidity, a smart dose of castor oil, and oil of turpentine for the bowels, and to have a dose of morphia three times daily.Mr. Lawrence observed, as the result of his experience, that the bowels are always very much loaded in these cases; if, indeed, the fons et origo of the malady be not altogether seated in this state of the alimentary canal.January 10th.The stifness of the neck is the same; abdomen yet as hard as before; rigidity of muscles still persistent.Ordered large doses of calomel, and extract of colocynth, with two grains of disulphate of quinine, every six hours, and a full dose of morphine at bedtime; the case now being one of decided tetanus.January 14th.He is much worse: he cannot even bear the bed clothes on him; is restless and dissatisfied.January 16th.Not better; tetanic symptoms continue; ordered ten ounces of wine, and to increase the morphia.January 2ird.The first signs of amendment are appa- rent; the rigidity of the jaw is less; the abdomen is still hard and tense; body is bent forward, what might be called emprosthotonos.He complains of aching pains
New Information Sheets for IRBs and Clinical Investigators Available
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
La cystographie.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tipifarnib Targets <i>HRAS</i>-Mutant Cancers
Journal: Cancer Discovery (2019)

Abstract Tipifarnib may be effective in treating HRAS-mutant head and neck squamous cell carcinoma. In a phase II trial, the drug elicited responses in 10 of 18 patients with HRAS mutations at a variant allele frequency of at least 20%, and responders had a median progression-free survival of 8.3 months.
Medical Education In China
Authors: Thomas W. Hynes
Journal: JAMA (1972)

<h3>To the Editor.—</h3> My explanation of the mechanism would be the following: Appropriate counter-irritation sufficient to overcome the chronaxie and flood the neural lines thus obstructing the receipt of incoming calls or afferent impulses accustomed to using the same neural conduit. Homily would be a party telephone wire which you cannot use until the other fellow hangs up. It seems to me that this might be a decided improvement on aluminum hydroxide gel and magensium hydroxide (Maalox), aluminum hydroxide (Amphojel), in the treatment of peptic ulcer.
Impact of Environment, Stress, Occupational, and Other Hazards on Sexuality and Sexual Behavior
Authors: John Bancroft
Journal: Environmental Health Perspectives (1993)

Sexual health is important for general as well as reproductive health.The effects of the environment on sexual health are complex, however, because of the psychosomatic nature of human sexuality.The effects of any specific environmental agent on sexual function will therefore be modified or amplified by psychosocial factors, and any assessment of the effects of the agent will need to take those factors into account.As a consequence, we have little direct evidence of the adverse effects of the environment on sexuality.This paper therefore considers a) the aspects of sexuality that may by susceptible to environmental effects and the likely mediating mechanisms.These are considered under three headings: psychophysiological, endocrine, and subjective/interpersonal; b) the types of relevant environmental factors, including toxic pollutants, self- administered toxins, diet, situational factors, adversity, stress, and social and cultural factors.As yet research has not controlled adequately for the various confounding factors.It is suggested that a first step is to investigate the effects of work stress (e.g., shift and night work) on sexual relationships, comparing the effects across contrasting cultural settings.Such research would then provide a basis for cross-cultural study of other environmental factors.
Augmenter of liver regeneration: Its place in the universe of hepatic growth factors
Authors: A Francavilla
Journal: Hepatology (1994)

As every school child knows, chameleons can regenerate a lost tail.Indeed, regrowth of appendages is a not uncommon phenomenon among other lower animals.In mammals, however, regenerative capacity is much more restricted.The special regenerative capability of the mammalian liver has been recognized over millennia, as epitomized by the ancient legend of Prometheus.The explanation for liver regeneration has been of interest to investigators for more than a century.With the convergence in our laboratory of two lines of inquiry more than a third of a century ago, this quest for understanding received a major stimulus.The first theme concerned the cross regulation of the liver and nonhepatic splanchnic organs, especially involving insulin in the pancreaticohepatic axis (1-3).In experiments with Eck's fistula (portacaval shunt), the liver's first pass exposure to the hormone and nutrient-rich venous blood coming from all of the other splanchnic organs was eliminated.Liver atrophy already was well-known to be caused by this operation (41, but was generally ascribed to reduction in total hepatic blood flow, rather than to the loss of a particular kind of blood.Although this "flow hypotheses" of portal physiology was established dogma well into the 1960s, proving or disproving it was quite another matter.In 1961, after a
Long-term follow-up of patients with primary biliary cirrhosis on colchicine therapy
Authors: A Zifroni
Journal: Hepatology (1991)

We followed up a group of patients with primary biliary cirrhosis who participated in a 4-yr prospective, double-blind controlled trial of colchicine therapy for 4 additional years. All were placed on open label colchicine (0.6 mg twice daily) after the trial was concluded. Of the original group of 28 patients treated with colchicine, 8 died and 5 recieved transplants (3 of the 5 died). Of the original placebo control group eight patients died and six received transplants (1 of the 6 died). Surviving patients on long-term colchicine therapy (mean period = 8.1 yr, range = 5.3 to 9.1) showed reduction of mean serum alkaline phosphatase from 5.1 times the upper limit of normal values to 1.9 times (p < 0.01). Mean ALT fell from 1.8 to 1.2 times the upper limit of normal (p = 0.05), and mean serum total bilirubin remained stable (1.6 mg/dl vs. 1.5 mg/dl). Major complications of cirrhosis developed in four patients in the colchicine group and five patients in the original control group. The only side effect of colchicine was diarrhea, which was noted in three patients. The diarrhea resolved with reduction in the dose of colchicine. Colchicine is a safe and inexpensive drug for the long-term treatment of primary biliary cirrhosis. The biochemical parameters of disease activity (alkaline phosphatase and ALT) remain improved after long-term follow-up, and bilirubin values remain stable. However, complications of cirrhosis, deaths and transplantations were not prevented. The clinical usefulness of colchicine in the treatment of primary biliary cirrhosis seems to be limited. (HEPATOLOGY 1991;14:990–993.)
Journal of Occupational Medicine, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SEX BASED DIFFERENCES IN OUTCOMES OF PATIENTS WITH ACUTE LIMB ISCHEMIA UNDERGOING ENDOVASCULAR TREATMENT
Authors: Aakash Sheth, Harsh Patel, Kirtenkumar Patel, Samarthkumar Thakkar, Krunalkumar Patel, Smit Patel, Devina Adalja, Fadee Kutom, Toralben Patel, Fahria Parisha, Marmik Patel, Tanushri Bhushan, Rajkumar Doshi, Sidakpal Panaich
Journal: Journal of the American College of Cardiology (2021)
Pneumoconiosis
Authors: J. C. Gilson, G. S. Kilpatrick
Journal: BMJ (1955)

Siglec-G is a negative regulator of BCR-mediated signaling in B1a cells. This population of B cells is highly increased in Siglec-G–deficient mice, but the mechanism of this expansion is not known so far. In this study, we demonstrate that <i>Siglecg<sup>−/−</sup></i> B1a cells show a lower level of spontaneous apoptosis and a prolonged life span. Mechanistically, the lower apoptosis could result from higher expression levels of the transcription factor NFATc1 in Siglec-G–deficient B1a cells. Interestingly, <i>Siglecg<sup>−/−</sup></i> B1a cells display an altered BCR repertoire compared with wild-type B1a cells. As the BCR repertoire and the VDJ composition of Igs of <i>Siglecg<sup>−/−</sup></i> B1a cells resembles more the Abs produced by adult bone marrow-derived B cells rather than canonical fetal liver-derived B1a cells, this suggest that the selection into the B1a cell population is altered in Siglec-G–deficient mice.
Die Pyelonephritis
Authors: Edward H. Kass
Journal: JAMA (1967)

Two major international symposia on pyelonephritis have been published in the United States, one in 1960 and the other in 1965. The present volume adds a third, held in Germany and composed almost exclusively of contributions from Middle Europe. The symposium was divided into several large sections: etiology and pathogenesis, pathological anatomy, pathophysiology, special diagnostic procedures, clinical aspects, special clinical problems, treatment, and prophylaxis and prognosis of pyelonephritis. There is, therefore, a broad attempt to cover the subject and to deal with its many ramifications. Unfortunately, relatively few of the contributors have made leading primary contributions to the field so that a great deal of the material represents reworking of data already published elsewhere. As is inevitable under such circumstances, the quality of the presentation varies. In some instances, the authors were clearly in command of the literature and of the implications of the substantial advances that have occurred in
Authors' reply
Authors: W. H. Koh, N. J. McHugh
Journal: Annals of the Rheumatic Diseases (1995)

Effect of gold treatment on cytokine expression in synoviumA recent paper in this journal described the effect of intramuscular gold treatment on cytokine expression in synovial membranes from patients with rheumatoid arthritis.1In that paper, the authors described changes in synovial membrane expression of interleukins (IL) IL-1a, IL-1,, IL-6, and tumour necrosis factor a in patients who had received intra- muscular gold treatment.However, the authors failed to mention that some of the results had been published in another journal by a similar group of authors.2Neither paper is cross referenced in the other, and it is not clear from these two papers whether the authors are reporting the same set of results in two different papers.In one paper,2 the authors described a significant failure rate with blind needle biopsy of the synovial membrane, which is particularly a problem with studies involving sequential biopsying as was performed in these two studies.Our experience is similar with this technique and we have now changed to performing all synovial biopsying under direct vision through a needle arthroscope under local anaesthesia.However, despite the fact that the two patient groups appear to be similar, if not identical, in these two papers, one paper states that only seven of 18 patients recruited in the study gave three satisfactory sequential synovial biopsy specimens,2 while the other paper implies, though does not clearly state, that satisfactory synovial biopsy specimens were obtained in all 10 patients for all time points (0, 2, and 12 weeks).1This suggests either that the authors' biopsying technique or success rate has changed dramatically during the period between preparation of the two papers, or that additional patients were obtained to 'make up the numbers'.Could the authors please confirm whether:(1) The patient groups studied in these two papers are, in fact, identical.(2) The same results for IL-1,B have been published in two different papers in two different journals.(3) All the patients reported in one paper' provide adequate synovial biopsy specimens for all three time points and, if so, how was this possible in view of the results and discussion in the other paper from the same group.
Effects of burns on the heart. A clinicopathological study in children
Authors: V. V. Joshi
Journal: JAMA (1970)

Analysis of clinicopathological data of seven fatal cases of burned children showed that congestive heart-failure was a major factor in their deaths. The possibility of an overload of fluid administered intravenously was ruled out. No detailed account of cases of this type was found in the literature. The patients had infected burns, prolonged clinical course, anemia, episodes of hypokalemia and hyperkalemia, systemic hypertension, and hypoproteinemia. At autopsy, all cases showed cardiomegaly with focal inflammatory and degenerative lesions of the myocardium. There is a possible relationship of the above factors and myocardial lesions to congestive heart-failure. Physicians should be alert to the possibility of congestive heart-failure in burned children.
European Perspectives
Journal: Circulation (2007)

C ardiology owes the presence of one of its leading prac- titioners to an unlikely turn of events.Tennis and the fact that the University of Barcelona did not offer an environment course combined to kick-start Dr Valentin Fuster's medical career.On the basis of his background, medicine seemed an obvious choice.His maternal grandfather had been president of the University of Barcelona and president of the medical school.Dr Fuster's paternal grandfather was a general physician in Majorca, and his father was a professor of psychiatry in Barcelona.His eldest brother is a neuroscientist working at the University of California, Los Angeles.But his parents did not pressure him to pursue medicine.Dr Fuster says, "I liked tennis and I liked creativity, so once I decided tennis was not my career, I decided to go into agriculture, where the peacefulness of nature and the research of land and the environment appealed to me."But at the time, Europeans normally studied at their home university, and Barcelona, where he was born, did not offer his first choice of studies.He therefore had to think of another option."I suspect that the combination of trying to help the patient and the challenge of research, trying to understand disease, together with my family history, led me at that time to consider becoming a doctor," he says.He listened to his father's advice and worked hard, something he admits he had not done up to that point."I was not a good student before I went to medical school," he explains."I was average, not taking my studies too seriously."His choice of cardiology is also in part attributable to tennis, which he had played competitively.A fellow member of the Barcelona tennis club was Pedro Farreras, MD, a professor of medicine at the medical school in Barcelona.Dr Farreras became Dr Fuster's mentor.When Dr Farreras had a heart attack in his 40s, he said to Dr Fuster, "You should Dr Valentin Fuster is a product of a European medical education and one of Europe's most prominent cardiologists.He is now professor of medicine at the
Current Therapeutic Research, New York
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Internal Medicine (2020)

Collaborative Medication Reviews in Older Patients 181In this cluster randomized clinical trial, Romskaug and colleagues investigated the effect of clinical geriatric assessments and collaborative medication reviews by geriatricians and family physicians on health-related quality of life and other patient-relevant outcomes in homedwelling older patients receiving polypharmacy.The study intervention consisted of clinical geriatric assessment of the patients combined with a thorough review of their medications, a meeting between the geriatrician and the family physician, and clinical followup.Results showed that health-related quality of life at follow-up at 16 weeks was statistically significantly better in patients who received the intervention compared with those who received usual care. Testosterone Therapy and Venous Thromboembolism Risk 190Walker and colleagues performed this case-crossover study to assess whether testosterone therapy is associated with short-term risk of venous thromboembolism in men with and without hypogonadism.Men in the case period were matched with themselves in the control period.Case periods of 6 months, 3 months, and 1 month before the venous thromboembolism events were defined, with equivalent control in the 6 months before the case period.National drug codes were used to identify billed testosterone therapy prescriptions in the case period.Use of testosterone therapy in the 6-month case period was associated with an increased risk of venous thromboembolism among men both with and without hypogonadism.
Correction
Journal: Circulation (1973)

Eckberg DL et al.: Circulation 47: 1252, 1973. On page 1253, the formula should read [See Equation in PDF File] where P = intracavitary pressure in g/cm 2 , r 1 = internal left ventricular cavity radius, h = wall thickness at the minor left ventricular circumference, and L = long axis of the left ventricle.
Sudden sniffing death
Authors: M. Bass
Journal: JAMA (1970)

An epidemic of 110 sudden sniffing deaths without plastic bag suffocation which occurred in American youths during the 1960's, appears to have originated on the West Coast. The incidence rate showed a sharp rise during the late 1960's. Volatile hydrocarbons most frequently involved were trichloroethane and fluorinated refrigerants. Sudden sniffing death occurred in all socioeconomic groups, with a preponderance in the suburban middle-income white family. Severe cardiac arrhythmia, resulting from light plane anesthesia, and intensified by hypercapnia or stress or activity or a combination of these, is the most likely explanation for sniffing death.
Public Health and Aging: Influenza Vaccination Coverage Among Adults Aged ≥50 Years and Pneumococcal Vaccination Coverage Among Adults Aged ≥65 Years—United States, 2002
Authors: Janet Torpy, Cassio Lynm, Richard Glass
Journal: JAMA (2003)

Cerebral Palsy Cerebral palsy is a term that describes a variety of disorders of movement or posture.These movement problems are due to brain abnormalities that occur early in development.Cerebral palsy affects motion, muscle strength, balance, and coordination.These problems are first noted in early childhood and continue into adult life.The muscles of speech, swallowing, and breathing may be involved.Intellectual disabilities (mental retardation) and seizures can also occur, but these problems are not always present.There are about 500 000 persons who have cerebral palsy in the United States.The