tbuckley/cabot-search huggingface dataset:
Dentures.
Authors: O J Corrado
Journal: BMJ (1990)

and presenting information for which the knowledge available is unclear, poorly defined, uncertain (for instance, the long term effects of the contraceptive pill in terms of risk of breast cancer or the problem of its interactions).An educational approach to possible lines of action in situations of uncertainty is indeed needed, both on the part of the public and of the doctors, together with a mechanism allowing the timely updating of information.A systematic long term exercise in preparing and testing consumer oriented drug information should be given priority in the near future; it should not only be directed to avoid inappropriate and potentially dangerous drug use but also towards fostering a more conscious attitude with respect to drugs among the public.Community pharmacists represent an important resource in the promotion of educational practices; doctors, on their part, should be prepared to face and to encourage dialogue oriented relationships with patients.
Highlights from the Literature
Authors: David Schiff, Sean Lawler, Marc Chamberlain, Karen Wright, Krishna Bhat
Journal: Neuro-Oncology (2016)

Clinical relevance of molecular classification of posterior fossa ependymomasThe classification of ependymomas, tumors with a variety of histological subtypes and anatomic locations, is beginning to yield to molecular classification based upon genomic analyses.Specifically, posterior fossa ependymomas can be sorted into two subtypes based upon genetic and methylation profiles: EPN_ PFA and EPN_PFB (also known as Group A and Group B).In contrast to Group B, Group A ependymomas tend to occur in young children, to be laterally located, to be more invasive with higher metastatic potential, and to have increased DNA methylation and worse prognosis.Historically, standard therapy for pediatric posterior fossa ependymomas includes maximal safe tumor resection followed by involved field radiation therapy.Extent of resection is recognized as the most important prognostic factor.To determine the relative contributions to prognosis of molecular tumor classification, extent of resection, patient age and radiation therapy, an international collaboration amassed a large retrospective cohort of these rare tumors.Taylor and colleagues collected clinical data and performed unsupervised hierarchical clustering of genome-wide methylation arrays on 4 cohorts comprising a total of 820 posterior fossa ependymomas.Eighty-three percent of cases were Group A and 17% Group B; children younger than five years were almost exclusively Group A, adults were 89% Group B, and children aged 10-17 were evenly divided between the two groups.Multivariate modeling demonstrated that molecular subgroup was by far the strongest predictor of overall and progression-free survival (OS and PFS), with extent of resection and adjuvant radiation therapy also being significant factors.Group A patients had a much worse outcome independent of age (OS-10 yr approximately 50%) and did especially poorly with subtotal resection; postoperative radiation in this setting was of limited benefit.In contrast, Group B patients with gross total resection did very well in general, and some may be cured even without adjuvant radiation.Moreover, some Group B patients who recurred following gross total resection were apparently salvaged with re-resection followed by radiation.Subtotally resected Group B patients had a PFS-10 yr of 50%.Overall survival
Massage and the Original Swedish Movements. Their Application to Various Diseases of the Body. Lectures Before the Training Schools for Nurses Connected with the Hospital of the University of Pennsylvania, German Hospital, Woman's Hospital, Philadelphia Lying-in Charity Hospital, the Philadelphia Polyclinic and College for Graduates in Medicine, and the Kensington Hospital for Women, of Philadelphia.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply to Letter to the Editor
Authors: L. Lim, Y. Chan, K. Ho, K. Yeoh
Journal: Endoscopy (2011)

We would like to thank Lim et al. for their letter. Our study showed that endoscopy within 13 hours of presentation was associated with lower mortality in high-risk but not low-risk nonvariceal upper gastrointestinal bleeding (NVUGIB), as triaged by the Glasgow-Blatchford score (GBS) [1].
THE EVALUATION OF SCIENTIFIC MANUSCRIPTS
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elective versus therapeutic neck dissection in the clinically node negative early oral cancer: A randomised control trial (RCT).
Authors: Anil D'Cruz, Mitali Dandekar, Richa Vaish, Supreeta Arya, Gouri Pantvaidya, Pankaj Chaturvedi, Devendra Chaukar, P. S. Pai, Anuja Deshmukh, Shubhada Kane, Deepa Nair, Sudhir Vasudevan Nair, Asawari Patil, Rohini W Hawaldar, Manasi Dhopeshwarkar, Jaiprakash Agarwal
Journal: Journal of Clinical Oncology (2015)

LBA3 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Sunday, May 31, 2015, and in the Annual Meeting Proceedings online supplement to the June 20, 2015, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Sunday edition of ASCO Daily News.
Hepatic overexpression of caveolins increases bile salt secretion in mice
Authors: M Moreno
Journal: Hepatology (2003)

Caveolins are cholesterol-binding proteins involved in the regulation of several intracellular processes, including cholesterol transport. Because hepatocytes express caveolin-1 and caveolin-2, these proteins might modulate hepatic lipid metabolism and biliary lipid secretion. Our aim was to investigate the potential physiologic role of caveolins in hepatic cholesterol and bile salt (BS) metabolism and transport using adenoviral gene transfer. C57BL/6 mice were infected with recombinant human caveolin-1 and caveolin-2 adenoviruses. Mice infected with adenovirus lacking the transgene were used as controls. Hepatic caveolin expression was evaluated by immunochemical methods. Reverse-transcription polymerase chain reaction (RT-PCR) and immunoblotting were used to assess messenger RNA (mRNA) levels and protein mass of BS transporters (sodium taurocholate cotransporting polypeptide [Ntcp] and bile salt export pump [Bsep]). Serum, liver, biliary, and fecal biochemical determinations and BS maximal secretory rate (SRm) were performed by standard methods. Ad.Cav-1- and Ad.Cav-2-infected mice exhibited a 10- and 7-fold increase in hepatic caveolin-1 and caveolin-2 protein expression, respectively. Caveolin-1-overexpressing mice had a significant increase in plasma high-density lipoprotein (HDL) cholesterol and hepatic free cholesterol content, whereas total plasma cholesterol and triglyceride levels remained unchanged. Hepatic caveolin-1 and/or caveolin-2 overexpression significantly increased bile flow and secretion of all biliary lipids. Caveolin-1-overexpressing mice showed a 2.5-fold increase in taurocholate (TC) SRm, indicating increased canalicular BS transport capacity. BS pool size and fecal BS excretion remained within the normal range in mice with Cav-1 overexpression. No changes were seen in the protein mass of BS transporters Ntcp and Bsep. In conclusion, our findings indicate that caveolins may play an important role in regulating hepatic BS and cholesterol metabolism. (Hepatology 2003;38:1477-1488.)
Prevention of Rh Isoimmunization
Authors: Vincent J. Freda
Journal: JAMA (1967)

Many workers have shown conclusively that passive antibody is capable of specific immunosuppression of the active immunity that follows injection of an antigen.<sup>1-18</sup>It is also clear from experimental results in mice that specific IgG antibody is from 100 to 200 times more immunosuppressive than specific IgM antibody.<sup>18</sup>No attempts had been made to apply this very real immunological phenomenon as a means of immunosuppression for a practical purpose until in 1960 three of the authors (V.J.F., J.G.G., and W.P.) began a program to explore the possibilities of using passive antibody to prevent Rh-negative mothers from becoming immunized by Rh-positive fetuses.<sup>19-29</sup>Our specific hope that the method might work for Rh was supported by the implications of Levine's observations<sup>30</sup>and by actual experimental data of Stern et al,<sup>31</sup>that circulating anti-A and anti-B antibodies actually do prevent Rh-negative mothers from being sensitized to the Rh
LAW&amp;amp; MEDICINE
Authors: Angela Roddey Holder
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Pain
Authors: Eduardo Bruera, Hak Nam Kim
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P153: Genetic Linkage and Association of Echocardiographic Measures in the Fels Longitudinal Study
Authors: Audrey C Choh, Miryoung Lee, Joanne E Curran, Ellen W Demerath, Thomas D Dyer, Claire Bellis, Roger M Siervogel, John Blangero, Bradford Towne, Stefan A Czerwinski
Journal: Circulation (2013)

Measures of cardiac structure such as left ventricular mass (LVM) have been shown to be significantly heritable. Relative to other complex traits, however, gene variants influencing echocardiographic traits have been less frequently identified. In this study of subjects from the Fels Longitudinal Study, our aim was to perform quantitative trait linkage and genome-wide association (GWA) analyses on LVM, relative wall thickness (RWT), fractional shortening (FS), aortic root diameter (ARD), and LVM index (LVMI; LVM/height 2.7 ). The study sample consisted of 1,060 (467 male, 593 female) whites aged 8-97 years from 131 families. Variables were inverse normal transformed for all analyses. Each subject was genotyped with the Illumina Human 610-Quad BeadChip containing more than 550,000 single nucleotide polymorphism (SNP) markers. Variance-component linkage analyses were conducted using a subset of 17,561 genome-wide SNP markers in genetic equilibrium with each other. GWA analyses were conducted using all SNPs and the measured genotype method implemented in SOLAR, allowing for residual non-independence among relatives After adjusting for covariates of age, sex, BMI, and population stratification, all echocardiograpic traits were significantly heritable (p &lt; 0.00006); h 2 (SE) for LVM, LVMI, RWT, FS, and ARD were 0.28 (0.07), 0.36 (0.07), 0.22 (0.07), 0.27 (0.06), and 0.55 (0.06), respectively. Linkage analyses revealed significant linkage of LVMI to chromosome 1p31 (LOD=3.64 at 96cM) in a region where the LEPR (leptin receptor), PDE4B (phosphodiesterase 4B, cAMP-specific), NEGR1 (neuronal growth regulator 1), and TNNI3K (TNNI3 interacting kinase) genes are located. For ARD, we identified chromosomal region 13q14 (LOD = 3.88 at 45cM) which harbors the FOXO1 (forkhead box O1) and TSC22D1 (TSC22 domain family, member 1) genes. Suggestive (LOD &gt; 2.0) linkages were found on chromosomes 1, 2, 3, 4, 9 and 19 for the various traits. In GWA analyses, significant ( χ 2 &gt;27.85) association was found between LVMI and SNP rs7939215 on chromosome 11p15. For LVM we observed evidence of a suggestive association ( χ 2 &gt;22.70) with rs660464 in the NRG3 (neuregulin 3) gene, which has been associated with hypertrophy among the Amish. Other suggestive associations were found between FS and SNPs rs12485048 and rs5753622 on chromosome 22q12, and SNP rs2993639 chromosome on 3q21. In summary, we identified several significant linkage and association signals for cardiac measures. Future work will include replicating these results in other study populations.
Chronic Appendicitis
Authors: J. Mair
Journal: BMJ (1955)

<h3>Introduction</h3> Canadian salmon aquaculture is a high-risk industry with injury rates that surpass provincial averages in Atlantic Canada, yet few publications address occupational health hazards. Antimicrobial resistance (AMR) emergence is a growing public health concern, and the marine aquatic environment with its rich microbiota is particularly vulnerable to selection of AMR. Antibiotic use in the industry and other anthropogenic activities that result in the deposit of pollutants contaminated with antibiotics into the marine environment can together amplify selective pressure propagating AMR. Similar to terrestrial animal production facilities, there is concern for the development of hotspots for occupational exposures to AMR among aquaculture workers. As the fastest growing food production network globally, the aquaculture industry has been appealed by the Food and Agriculture Organization, among others, to standardize monitoring and to generate an evidence base to better understand the aetiology of AMR emergence in aquaculture settings. <h3>Objectives</h3> This case study will identify Canadian policies and practices that promote antimicrobial stewardship and surveillance in the aquaculture industry. Methods i) Compare antibiotic use by Canadian salmon aquaculture to other global industry leaders. ii) Compare regulatory regimes and surveillance strategies across industry leaders. <h3>Results</h3> Prescribed antibiotic use in Canadian salmon aquaculture exceeds that of Norway, the industry leader, which has implemented an array of strategies to drastically reduce antibiotic use since the 1990s. Unlike Norway, Canadian aquaculture lacks monitoring programmes for AMR and, furthermore, has yet to document possible occupational exposure pathways to this hazard. Current data repositories do not elucidate health risks associated with AMR emergence in aquaculture settings. <h3>Conclusion</h3> Canadian salmon aquaculture has an opportunity to lead the country’s animal production industries in the development of a standardized sentinel surveillance network to accommodate formal risk analyses and early warning systems. Continuous AMR surveillance coordinated with current public health monitoring would promote health protective strategy development and antimicrobial stewardship within the country.
Getting stents to go with the flow
Authors: R. W. Alexander
Journal: Journal of Clinical Investigation (2004)

Implantation of expandable stents into stenotic arteries after percutaneous coronary intervention to relieve arterial narrowing has become a standard therapeutic tool. The improvement in vascular interventional technology, and especially stent technology, has, arguably, outstripped understanding of the biologic consequences of opening an obstructed artery. In the case of bifurcation stenoses, new evidence suggests that opening a stenotic subsidiary branch may create unfavorable hemodynamics in the stented main branch that can lead to in-stent restenosis.
The impaired physician. Four years after probation
Authors: J. H. Shore
Journal: JAMA (1982)

IN RECENT years, increased interest and attention have been focused on problems of emotionally impaired physicians. In response to concern for the impaired physician who is under formal probation, the Oregon Board of Medical Examiners initiated an evaluation of the rehabilitation programs for probationers with substance-use disorders and psychiatric illness. This article reports on the evaluation of these rehabilitation programs and addresses several questions concerning the effectiveness of rehabilitation efforts with impaired physicians. Those questions include the following: What are the problem types and risk groups of physicians who are on probation with the State Board of Medical Examiners for a psychiatric disorder? Is there a predictable course for the physician's illness? What is the physician's response to treatment? What is the preferred treatment plan for each major problem? In 1972, the American Medical Association's Council on Mental Health published its report on "The Sick Physician."<sup>1</sup>This initiated an
Acute Rheumatic Fever Among Army Trainees— Fort Leonard Wood, Missouri, 1987-1988
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Talc and cornstarch emboli in eyes of drug abusers
Authors: W. E. AtLee
Journal: JAMA (1972)

A characteristic type of retinopathy due to talc and cornstarch emboli was observed in 17 drug addicts following repeated intravenous injections of crushed methylphenidate hydrochloride tablets taken for their stimulatory effects. Ophthalmoscopic examinations revealed tiny glistening crystals largely concentrated in the small vessels about the macula. Two patients with pulmonary hypertension had reduced vision, presumably from retinal edema. Histologic examination confirmed the presence of talc and cornstarch particles in the retina and choroid as well as in the lung and brain. The presence of these particles in the eye is an indication that considerable foreign-body damage has occurred in the lung.
ANOTHER COLLECTION COMPANY EXPLOITS PHYSICIANS
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal