tbuckley/cabot-search huggingface dataset:
SKIAGRAPHY IN MEDICAL JURISPRUDENCE.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Central Scotomata Due to Chlorpropamide
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BMS-986263 (novel targeted lipid nanoparticle delivering HSP47 siRNA) safety and target engagement in patients with advanced hepatic fibrosis: week 36 results from a phase 2 randomized, double-blind, placebo-controlled trial
Authors: Eric Lawitz, Diane Shevell, Ratna Revankar, Sheng Gao, Samir Wadhawan, Warner Chen, Giridhar Tirucherai, Shuyan Du, Naim Alkhouri, Angie Coste, Fred Poordad, Edgar Charles
Journal: Journal of Hepatology (2020)
Mental Health Problems of Homeless Women and Differences Across Subgroups
Authors: M. J. Robertson
Journal: Annual Review of Public Health (1996)

Homeless women are a large and diverse group, constituting one fifth of the US homeless adult population. Although most homeless women do not have major mental illness, homeless women exhibit disproportionately high rates of major mental disorders and other mental problems. Rates of mental disorders are highest among whites and women without children, and important variations by subgroups of homeless women reinforce the need for disaggregated analysis. Many homeless women with serious mental illness are not receiving needed care, apparently due in part to the lack of perception of a mental health problem and the lack of services designed to meet the special needs of homeless women.
American Pediatric Society.
Authors: Samuel S. Adams
Journal: JAMA (1895)

Hot Springs, Va., May 29, 1895. <h3>To the Editor:</h3> —Our Society has passed the following resolution: <i>Resolved</i>, That in the opinion of the American Pediatric Society the evidence thus far produced regarding the effects of diphtheria antitoxin serum justifies its further and extensive trial. Yours.
Worksite health promotion and health care costs and utilization
Authors: Robert C. Jones
Journal: JAMA (1987)

<h3>In Reply.—</h3> The letter by Dr Frumkin regarding our article raises two points of concern that bear response. His first point, that the article does not adequately express cautions concerning the results, appears to be muted by his direct quotation of caveats expressed in the article. He acknowledges that the authors seem to agree with his concerns. In particular, the need for a study that includes diagnostic data, in order to better trace any observed relationships, is clearly stated in the article. Further, the implication that the results rest on a single point would appear to ignore the trend analyses that were pursued for the five-year period. It should also be noted that the article reports that the analysis showed insignificant differences for outpatient costs, rather than "negative results," an important distinction. Evidence that higher health-knowledge levels were associated with higher outpatient and other health care costs might suggest that,
How would you decide?
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
To teach them this art
Authors: W. E. Lotterhos
Journal: JAMA (1966)

If Hippocrates could return today from Olympus and visit any one of the 88 accredited medical schools, he would, more likely than not, express enthusiastic approval of the curricula and general scientific attainment. His reaction to the state of the art, on the other hand, might be less than enthusiastic, and it may be logically supposed that his disappointment would be profound. In this era of diagnosis by computer, automated hospitals, closed-circuit television, and chemotherapeutic miracles, the failure and possible obliteration of the art of medicine are the prices being exacted in the purchase of scientific advancement. Nobody wants to return to the horse and buggy doctor or to the ridiculous caricature of the bearded saint by the child's bedside, but he had his good points. In the 19th century, Pasteur admonished us "to cure some, to relieve many, and to comfort all." The character and organization of medical services
Genomic analysis of circulating tumor cells (CTCs) from men with metastatic castration resistant prostate cancer (mCRPC) in the context of enzalutamide therapy.
Authors: Jing Li, Joshua Beaver, Rhonda Lynn Bitting, Simon Gregory, Andrew J. Armstrong
Journal: Journal of Clinical Oncology (2015)

5042 Background: Predictive biomarkers are essential to maximize benefit and minimize harms and costs in mCRPC. Goal of this study was to determine the feasibility of genomic analysis of DNA copy number changes and whole exome sequencing (WES) of CTCs from men with mCRPC receiving enzalutamide. Methods: We collected CTCs from men with mCRPC in the context of enzalutamide therapy. CTCs were isolated through red cell lysis, CD45 depletion, and flow sorting on EpCAM/CD45 expression. Whole genomic amplification, aCGH, and WES were performed. In aCGH, each sample hybridized with its own leukocytes. A copy number log ratio greater than 0.2 or less than -0.2 with at least 10 consecutive probes represents gain or loss. In WES, single nucleotide variant (SNV) or insertion/deletion (INDEL) was called if the site was covered by more than 10 reads. Results: We successfully profiled the genomic copy number of CTCs from 4 men with CRPC. We compiled copy gains and losses observed by aCGH in these 4 patients. Genomic copy gains in AR, EZH2, SPOP, CCND1, BRD4, MYC, FOXA1, ABL1, ABL2 and other genes were observed; while common losses of the locus including CHD1 FGFR2, PHLLP, NCOR1, NCOR2 were seen. During sequential analysis during enzalutamide resistant visceral progression, loss of AR amplification and gain of N-MYC was observed, consistent with evolution toward a neuroendocrine AR-independent clone. We successfully sequenced the whole exome from CTCs and leukocytes from a patient who progressed through enzalutamide therapy. We discovered many somatically acquired mutations in CTCs exome, including 138 SNVs and 47 INDELs in CTCs including NCOA1, MAX, NOD1,USP10, MLL, MMP8, which have been previously implicated in prostate cancer. Conclusions: Genomic analysis of whole genome DNA copy number changes and whole exome sequencing from CTCs of men with mCRPC are feasible and identified previously validated and novel complex genomic lesions. Our results suggest the potential of CTC genomic analysis to help identify and longitudinally track predictive biomarkers and novel targets of systemic therapy efficacy and resistance in men with mCRPC and form the basis for larger validation trials.
Prescription of oxygen concentrators for long term oxygen treatment.
Journal: BMJ (1988)

apart; forced expiratory volume in one second <1 5 1; and forced vital capacity <2 1).Two other patients had stable hypoxia shown on one occasion and a forced expiratory volume in one second of <1 5 1.A further two had only stable hypoxia documented on one occasion and no results from spirometry.Five patients were recommended concentrators without evidence of stable hypoxia: three had an arterial oxygen pressure >7 3 kPa and no values were documented in the two others.Six
Staphylococcal Infection in a General Hospital
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory Syncytial Virus and Recurrent Wheeze in Healthy Preterm Infants
Authors: Akane Minagawa
Journal: New England Journal of Medicine (2016)

conditions of the rear of the foot and front of the foot were more conducive to the development of melanomas than other areas of the plantar surface.Mechanical stress such as plantar pressure and shear stress is higher in these two areas than in other areas of the foot, 4 and this stress is associated with the development of skin ulcers in persons with diabetes and with the development of calluses. 5Taken together with these observations, our results suggest that mechanical stress also increases the formation of melanomas on the plantar surface.Studies to determine the pathogenesis of melanoma in plantar regions are lacking.
How will patients use acyclovir to treat herpes?
Authors: M. L. Fuerst
Journal: JAMA (1982)

With the availability of the first topical agent to show any efficacy in herpes genitalis, desperate patients with recurrent herpes infections may practice self-medication—not surprisingly—once they have a prescription for the agent. But some herpes experts believe that widespread long-term use of the drug—which is only indicated for<i>initial</i>herpes infections and for genital and labial herpes in immunocompromised patients—may facilitate the emergence of resistant organisms and limit the agent's future usefulness in life-threatening situations. Recent Food and Drug Administration approval and marketing of the antiviral agent acyclovir (Zovirax, Burroughs Wellcome Company, Research Triangle Park, NC) will raise the hopes of many US patients afflicted with recurrent venereal herpes, predicts Andre Nahmias, MD, chief of infectious diseases, allergy, and immunology at Emory University, Atlanta. "Some people will apply it four to six times a day [treatment of initial infections is six applications per day for seven days], thinking they will
Perchloroethylene intoxication.
Authors: J K McMullen
Journal: BMJ (1976)

showed the beneficial effect of dapsone in preventing the spread of the disease.I have also been surprised at the decision by the faculty to teach leprosy to medical students in the leprosarium, especially at Garkida, where there is an emphasis on institutional care, reconstructive surgery, and the making of prostheses and where so much time and money are spent on the patients after they have become crippled and so little on curing the patients and preventing the spread of the disease.The place to teach leprosy is in the outpatient clinic run by auxiliary staff, and the area around the medical school would be ideal for this purpose.Then it could be demonstrated that the disease can be cured, prevented, and eradicated by the administration of dapsone.
Management of the Severely Anemic Jehovah's Witness
Authors: Marianne Mann
Journal: Annals of Internal Medicine (1993)

Letters15 July 1993Management of the Severely Anemic Jehovah's WitnessMarianne Mann, MD, John J. Votto, MD, and Joseph Kambe, MDMarianne Mann, MDSearch for more papers by this author, John J. Votto, MDSearch for more papers by this author, and Joseph Kambe, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-2-199307150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the comments of Drs. Auerbach and Ballard regarding the use of intravenous iron dextran as a total dose infusion.Dr. Green's statement that albumin is considered acceptable by the Church is incorrect. The Church leaves this decision up to the individual based on the precedent that it passes freely between mother and fetus, as per our discussion with a Watchtower spokesperson in New York.Drs. Youn and Burns correctly point out that hyperbaric oxygen therapy has been used in severely anemic patients who refuse blood transfusion. Hart and colleagues' review [1] of 26 patients treated with ...References1. Hart G, Lennon P, Struiss M. Hyperbaric oxygen in exceptional acute blood loss anemia. J Hyperbaric Med. 1987; 2:205-10. Google Scholar2. Youngberg JA. Aprotinin and thrombus formation on pulmonary artery catheters: a piece of the coagulation puzzle. J Cardiothorac Anesth. 1990; 4:155-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1993Volume 119, Issue 2Page: 169-170KeywordsDrugsFood and Drug AdministrationHemorrhageHeparinHyperbaric oxygenLipidsPlateletsProspective studiesProteinsPulmonary artery catheters ePublished: 15 August 2000 Issue Published: 15 July 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 4780: An antisense-based approach to induce anti-tumorigenic variants of MET receptor
Authors: Trushar Rathod, Luca Cartegni
Journal: Cancer Research (2019)

Abstract Rational: Aberrant activity of MET receptor, a receptor tyrosine kinase (RTK), is implicated in various forms of cancer. Moreover, functional crosstalk of MET with other RTKs has been reported in tumors and MET has emerged both as a driver and as a primary mechanism of resistance, thus, making MET an attractive target for cancer therapeutics. Aim: Recently, we have described natural soluble decoy variants for multiple RTKs (sdRKTs), including MET, which can antagonize RTK signaling by ligand sequestration and non-functional dimerization. These isoforms can be generated via intronic polyadenylation (IPA) of RTK’s pre-mRNA in a U1-snRNP dependent manner. Our aim is to activate IPA in MET pre-mRNA using antisense compounds and to increase mRNA variants that express dominant-negative soluble decoy MET (sdMET). Methods: Identify actionable IPA sites within introns upstream of the transmembrane-coding exon. Express potential sdMET isoforms and characterize their biological properties. For sdMET isoforms with inhibitory functions, anti-sense compounds are utilized to block the upstream U1 binding site, activate IPA sites, and thus increase expression of sdMET variants in MET-dependent cancer cells. Results: Ectopically expressed sdMET isoforms are secreted into the culture medium. When then added to MET-expressing cells, sdMET variants functioned in a dominant-negative manner over full length MET (FL-MET) and suppressed activation of AKT and MAPK pathways. Moreover, antisense compounds that induce IPA effectively convert oncogenic FL-MET into sdMET variants in multiple cell lines, leading to suppression of downstream pathways and dramatic reduction in cell viability of MET-dependent cells. Conclusion: Most sdMET isoforms are secreted into extracellular space and have inhibitory function. Our anti-sense approach induces IPA, generates truncated sdMET variants at the expense of FL-MET and efficiently blocks FL-MET’s biological activity. Citation Format: Trushar Rathod, Luca Cartegni. An antisense-based approach to induce anti-tumorigenic variants of MET receptor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4780.
Abstract 2585: The development of a novel microRNA replacement therapy for ovarian cancer - a potential of patient derived-exosomes as a carrier
Authors: Masaki Kobayashi, Kenjiro Sawada, Aasa Shimizu, Mayuko Miyamoto, Erika Nakatsuka, Mahiru Kawano, Yuri Matsumoto, Michiko Kodama, Kae Hashimoto, Seiji Mabuchi, Tadashi Kimura
Journal: Cancer Research (2019)

Abstract Objective: microRNAs (miRNAs) affect key features of cancer cells and some are identified as tumor suppressor (TS) miRNAs. In spite of many preclinical studies with promising results, all translational clinical trials with TS miRNAs have failed due to the difficulties of miRNA systemic delivery. Therefore, the development of a novel carrier is urgently needed. Exosomes, non-sized vesicles secreted from cells, are stable in body fluid and therefore can serve as a promising candidate for miRNA carrier. In ovarian cancer treatment, omentum should be taken at surgery and normal fibroblasts can be collected from omentum. The aim of this study is to pursue the possibility of fibroblast derived-exosomes as a carrier for miRNA replacement therapy to treat ovarian cancer. Methods: At surgery, omentum was collected and fibroblasts were primary cultured. Thereafter, exosomes were collected from culture media. miR-199a-3p was selected as a TS miRNA. Synthesized miR-199a-3p was corporated into exosomes by electroporation. miR-199a-3p-loaded exosomes (M199-exosomes) were treated with ovarian cancer cells and the expression levels of miR-199a-3p and target genes were assessed. The treatment effect of M199-exosomes was analyzed focusing on peritoneal dissemination. Results: The treatment of M199-exosomes drastically increased miR-199a-3p expression in ovarian cancer cells (CaOV3; 8592-fold, SKOV3; 67188-fold, OVCAR3; 2280-fold). Treatment with M199-exosomes suppressed c-Met expression and significantly inhibited the proliferation and invasion of ovarian cancer cells in vitro (P&amp;lt;0.01). In a xenograft study, M199-exosomes significantly inhibited peritoneal dissemination and extended the survival of mice. Citation Format: Masaki Kobayashi, Kenjiro Sawada, Aasa Shimizu, Mayuko Miyamoto, Erika Nakatsuka, Mahiru Kawano, Yuri Matsumoto, Michiko Kodama, Kae Hashimoto, Seiji Mabuchi, Tadashi Kimura. The development of a novel microRNA replacement therapy for ovarian cancer - a potential of patient derived-exosomes as a carrier [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2585.
Clinical Lecture on the Treatment of Rheumatic Fever, and of the Use of Alcohol in Serious Cases of this Disease
Authors: L. S. Beale
Journal: BMJ (1862)

oxysms, but iterated, keeping on; never urgent, yet not passing half a minute without occurring; feeble, with a certain throat-hoarseness about it, having rather a choking character, and with no expectora- tion as its result.When I say no expectoration, I should say there was no expectoration; but a little is now appearing.
Isotope scanning for diagnosing lesions projecting into the lower chest
Authors: G. Gonzalez
Journal: JAMA (1971)

Intra-abdominal masses, particularly those arising from the liver and spleen, may project into the lower part of the chest and thus necessitate an extensive diagnostic work-up. The use of liver and spleen isotope scans early in the evaluation of such cases will frequently provide the correct diagnosis and save significant time and cost.
Effectiveness of interventions to help people stop smoking: findings from the Cochrane Library
Authors: Tim Lancaster, Lindsay Stead, Chris Silagy, Amanda Sowden
Journal: BMJ (2000)

Review GroupPeto estimates that current cigarette smoking will cause about 450 million deaths worldwide in the next 50 years.Reducing current smoking by 50% would avoid 20-30 million premature deaths in the first quarter of the century and about 150 million in the second quarter. 1 Preventing young people from starting smoking would cut the number of deaths related to tobacco, but not until after 2050.Quitting by current smokers is therefore the only way in which tobacco related mortality can be reduced in the medium term.There is evidence that some form of treatment aids an increasing number of successful attempts to quit. 2 This review aims to summarise evidence for the effectiveness of the available interventions.