tbuckley/cabot-search huggingface dataset:
Perspective from a quarter century of antibiotic usage
Authors: G. G. Jackson
Journal: JAMA (1974)

We are at a point in the antibiotic era where one can begin to look back on the historical development of chemotherapy. These events have affected our lives in many ways including discovery, investigation, education, regulation, and miraculous cure of disease. It is clear that by our use, overuse, and abuse of chemotherapy in our present practices, we have failed to reach the optimal treatment of infectious diseases and have created some new problems. Our vantage point provides enough experience to have perspective, sufficient new knowledge to make us wiser, and vision to motivate realistic, critical assessment, and find new aspirations and aims.
Accumulation of Radionuclides by Plants as a Monitor System
Authors: John J. Koranda, William L. Robison
Journal: Environmental Health Perspectives (1978)

The accumulation of radionuclides by plants acting as a monitoring system in the environment may occur by two modes; foliar absorption by the leaves and shoot of the plant, or by root uptake from the soil. Data on plant accumulation of radionuclides may be obtained from studies of fission product radionuclides deposited as worldwide fallout, and from tracer studies of plant physiology. The epidermal features of plant foliage may exert an effect upon particle retention by leaves, and subsequent uptake of radionuclides from the surface. The transport of radionuclides across the cuticle and epidermis of plant leaves is determined in part by the anatomy of the leaf, and by physiological factors. The foliar uptake of fallout radionuclides, 99Sr, 131I, and 137Cs, is described with examples from the scientific literature. The environmental half-life of 131I, for example, is considerably shorter than its physical half-life because of physical and biological factors which may produce a half-life as short as 0.23/day. 99Sr and 137Cs are readily taken up by the leaf, but 137Cs undergoes more translocation into fruit and seeds than 99Sr which tends to remain in the plant part in which it was initially absorbed. Soil-root uptake is conditioned primarily by soil chemical and physical factors which may selectively retain a radionuclide, such as 137Cs. The presence of organic matter, inorganic colloids (clay), and competing elements will strongly affect the uptake of 99Sr and 137Cs by plants from the soil. The role of plants as monitors of radionuclides is twofold: as monitors of recent atmospheric releases of radionuclides; and as indicators of the long-term behavior of aged deposits of radionuclides in the soil.
Correspondence
Authors: M. G. Good
Journal: Annals of the Rheumatic Diseases (1949)

A commonly used mouse model of asthma is based on i.p. sensitization to OVA together with aluminum hydroxide (alum). In wild-type BALB/c mice, subsequent aerosol challenge using this protein generates an eosinophilic inflammation associated with Th2 cytokine expression. By constrast, in DO11.10 mice, which are transgenic for an OVA-specific TCR, the same treatment fails to induce eosinophilia, but instead promotes lung neutrophilia. In this study, we show that this neutrophilic infiltration results from increased IL-17A and IL-17F production, whereas the eosinophilic response could be restored upon blockade of IFN-γ, independently of the Th17 response. In addition, we identified a CD4<sup>+</sup> cell population specifically present in DO11.10 mice that mediates the same inflammatory response upon transfer into RAG2<sup>−/−</sup> mice. This population contained a significant proportion of cells expressing an additional endogenous TCR α-chain and was not present in RAG2<sup>−/−</sup> DO11.10 mice, suggesting dual antigenic specificities. This particular cell population expressed markers of memory cells, secreted high levels of IL-17A, and other cytokines after short-term restimulation in vitro, and triggered a neutrophilic response in vivo upon OVA aerosol challenge. The relative numbers of these dual TCR lymphocytes increased with the age of the animals, and IL-17 production was abolished if mice were treated with large-spectrum antibiotics, suggesting that their differentiation depends on foreign Ags provided by gut microflora. Taken together, our data indicate that dual TCR expression biases the OVA-specific response in DO11.10 mice by inhibiting eosinophilic responses via IFN-γ and promoting a neutrophilic inflammation via microbiota-induced Th17 differentiation.
Molecular subtyping using MammaPrint and BluePrint as an outcome predictor in 180 U.S. breast cancer (BC) patients.
Authors: Lisette Stork-Sloots, Katharine Yao, Mary Turk, Karen Kaul, JoEllen Weaver, Femke De Snoo, Massimo Cristofanilli
Journal: Journal of Clinical Oncology (2012)

577 Background: Combined use of MammaPrint and a molecular subtyping profile (BluePrint) identifies disease subgroups with marked differences in long-term outcome and response to neo-adjuvant therapy (Glück SABCS2011). The aim of this study was to evaluate the prognostic value of Molecular Subtyping using MammaPrint and BluePrint in women with early stage BC treated at US Institutions following National Comprehensive Cancer Network (NCCN) standard guidelines. Methods: Frozen tumor samples from 180 BC patients (TI-III, N0-Ib) median age 57 years at diagnosis (range 28-89) were suitable for hybridization on full genome array. MammaPrint and BluePrint Molecular Subtypes were determined and survival for Luminal A (MammaPrint Low Risk), Luminal B (MammaPrint High Risk), HER2-type and Basal-type patients was assessed. Patients were treated either with breast conserving therapy or mastectomy with axillary lymph node dissection between 1992 and 2005. The median follow-up is 12.7 years. 71% was ER positive and 20% Her2 positive by IHC/FISH. 58% received adjuvant endocrine therapy (ET) (excluding 13 patients unknown treatment), 64% received adjuvant chemotherapy (CT) (excluding 12 patients unknown treatment) and 33% received both. Results: 61 (34%) Patients with MammaPrint Low Risk/Luminal-type (Luminal A) showed 5-year DFS of 97% (34% received CT and 69% ET) and 50 (28%) patients with MammaPrint High Risk/Luminal-type (Luminal B) had a 5-year DFS of 98% (60% received CT and 68% ET). Patients with BluePrint Basal-type tumors (46 (26%)) had a 5-year DFS of 80% (78% received CT); HER2-type (23 (13%)) had a 5-year DFS of 78% (87% received CT without HER-2 targeted therapy). Conclusions: In this retrospective study evaluating 180 US patients with early BC treated according to standard guidelines we showed how combining BluePrint with MammaPrint can detect molecularly defined subgroups of patients who are at high risk of recurrence (HER2 and Basal-type). Furthermore, we confirmed that molecularly defined Luminal type disease is associated with excellent disease-free survival. MammaPrint and BluePrint molecular and prognostic stratification should be prospectively evaluated for therapeutic selection.
THE CONTINUANCE OF OUTBREAKS OF BOTULISM
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAAD Case Reports Article List
Authors: Lan Jiang, Yi Ge, Zhu You, Lindsay Boyers, Chante Karimkhani, Emily Stevens, Whitney High, Adri An Imbern On-Moya, Elena Vargas-Laguna, Alejandro Lobato-Berezo, Marcela Mart Õnez-P Erez, Micaela Churruca-Grijelmo, Antonio Aguilar-Mart Õnez, Eva Fern Andez-Cogolludo, Miguel Gallego-Vald, Michael Noparstak, Brianna Mcdaniel, Joy King, Robert Brodell, Peter Rady, Ramya Killipara, Stephen Tyring, Sayantani Chakraborty, Joyeeta Chowdhury, Abhishek De, Ramesh Gharami, Lisa Mask-Bull, Ramya Vangipuram, Bryan Carroll, Michelle Tarbox, Casey Wang, Nicole Reusser, Megan Shelton, Jace Reed, Hung Doan, Carlos Torres-Cabala, Bouthaina Dabaja, Madeleine Duvic, Jonathan Salik, Randy Tang, Kristin Nord, Paul Schneiderman, Marc Grossman, Ming-Chun Hsu, Chih-Chiang Chen, Olga Vornicova, Gil Bar-Sela, Amy Chen, Anar Mikailov, Beverly Faulkner-Jones, Peggy Wu, Elizaveta Belyaeva, Rosalie Elenitsas, Rudolf Roth, Christopher Miller, Joel Gelfand, Melanie Clark, Joan Guitart, Pedram Gerami, Benjamin Marks, Sapna Amin, Simon Yoo, Laura Pruitt, Ling-Lun Hsia, William Burke, Bryce Desmond, Lauren Boudreaux, John Young, Bridget Mcilwee, Ryan Hick, Stephen Weis, Pooja Virmani, Esther Chung, Alissa Thomas, Ingo Mellinghoff, Michael Marchetti, Daniel Costa, Toshiki Ito, Fumihide Iwata, Pan Xu, Lixiong Gu, Xiaodong Yao, Xiaoyan Wu, Xiaodong Chen, Marta Kogut, Eva Hadaschik, Stephan Grabbe, Mindaugas Andrulis, Alexander Enk, Wolfgang Hartschuh
Journal: Journal of the American Academy of Dermatology (2015)
Trends in Lung Cancer Incidence and Mortality—United States, 1980-1987
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BRONCHOTRACHEAL RESPONSE IN HUMAN INFLUENZA
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognosis in Endocardial Fibroelastosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Opinions of Dutch physicians, nurses, and citizens on health care policy, rationing, and technology
Authors: T. Tymstra
Journal: JAMA (1993)

In many Western countries, there is in-depth discussion about the health care system: how should the services be distributed and what criteria should play a role? The Dutch health care system is also under debate. In the Netherlands, public policy aims at ensuring that everyone has access to necessary health care. To this end, a system of compulsory and voluntary insurances has been organized. In the Netherlands, both the public and private sectors make significant contributions to the health care services. Government regulations cover physician fees, hospital budgets, new medical technologies, and the provision of hospital beds. Some 62% of the population—the lower-income groups—obtain health services through the<i>ziekenfonds</i>, or sickness funds. The remaining 38% of the population purchase private health insurance from nonprofit and profit-making insurance companies. General practitioners are paid on a capitation basis for patients in the sickness funds and on a fee-for-service basis for patients with
Ligue Internationale contre le Rhumatisme: Eighth International Congress, Geneva, 1953
Authors: R Stecher, W Tegner, Richard Smith, A Moreno, G Edstrom
Journal: Annals of the Rheumatic Diseases (1953)

The eighth International Congress of the Ligue Internationale contre le Rhumatisme was held in Geneva from August 23-28, 1953.Over 800 delegates attended and 173 papers were given.Through- out the sessions the three conference halls, each with its ear-phones for simultaneous translations, were always well occupied.The Swiss committee, under the chairmanship of Prof. K.-M.Walthard, was untiring, and must be congratulated in that there did not appear to be one single part of the conference that did not run smoothly.One day was spent at Aix-les-Bains, when cases and films were shown, and there were excur- sions on the lake and into the mountains.
Selecting Criteria for the Diagnosis of “Diabetes Mellitus”
Authors: John B O'Sullivan, Stefan S Fajans
Journal: Diabetes Care (1981)

We would agree with Drs. O'Sullivan and Fajans1 that neither the National Diabetes Data Group nor any other proposals should be accepted uncritically; indeed we have ourselves already entered into the polemic on the subject and we welcome it.2 The proposals will no doubt require modification if and when relevant new data appear. However, the Group's report was the result of a critical review of the unsatisfactory situation concerning, at a certain level, the diagnostic criteria and, at another, the concept of diabetes itself. It took its direction from the availability of new data. Contrary to O'Sullivan and Fajans' statement, the blood glucose levels adopted were based largely on three prospective studies in the United Kingdom, and not on the Pima Indian data, which was regarded as confirming, in a different and special population group studied by different methods, the findings in the United Kingdom.
Table of Contents
Authors: Mariasole Da Boit, Angus Hunter, Stuart Gray, Faiza Siddiqui, Azra Kurbasic, Ulf Lindblad, Peter Nilsson, Louise Bennet, Ji Huh, Joon Kwang, Seung Kim, Hwan Kim, Kwang-Hyub Han, Bong-Soo Han, Hee Choon, Byung-Wan Chung
Journal: Metabolism (2016)
Law and Medicine
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery, Irradiation, Chemotherapy: All Valuable In Treating Testicular Tumors
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Presence of Spirochetes in Late Seronegative Syphilis
Authors: J. Lawton Smith
Journal: JAMA (1967)

Late seronegative syphilis refers to clinical signs of ocular or neurosyphilis in a patient whose routine blood (reagin) test is nonreactive, but in whom a specific treponemal test is reactive. This report documents the presence of spirochetes in aqueous humor, cerebrospinal fluid, and at liver biopsy in such patients. Spirochetes have been found in the aqueous humor with no biomicroscopic abnormality and in cerebrospinal fluids which had normal cell counts, protein levels, and reagin and colloidal gold test results. Identification of the organisms depends on use of the fluorescein antibody technique, in that spirochetes stain with fluorescein-tagged anti-<i>Treponema pallidum</i>globulin on ultraviolet microscopy.
THE CORN SUGAR DECISION
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal