tbuckley/cabot-search huggingface dataset:
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart
Authors: Joerg Heineke, Mannix Auger-Messier, Jian Xu, Toru Oka, Michelle A. Sargent, Allen York, Raisa Klevitsky, Sachin Vaikunth, Stephen A. Duncan, Bruce J. Aronow, Jeffrey Robbins, Timothy M. Crombleholme, Jeffery D. Molkentin
Journal: Journal of Clinical Investigation (2007)

During the preparation of the manuscript, an error occurred in the wording of the final sentence of the abstract.The correct sentence appears below.To our knowledge, these results demonstrate a previously unrecognized function for GATA4 as a regulator of cardiac angiogenesis through a nonhypoxic, load, and/or disease-responsive mechanism.The JCI regrets the error.
Megavitamins for minimal brain dysfunction. A potentially dangerous therapy
Authors: B. A. Shaywitz
Journal: JAMA (1977)

Vitamin A intoxication as a consequence of megavitamin therapy for minimal brain dysfunction occurred in a 4-year-old boy. An early clue to diagnosis was provided by an abnormal bone scan. (<i>JAMA</i>238:1749-1750, 1977)
The natural environment and emergence of antibiotic resistance
Authors: None The Lancet Planetary Health
Journal: The Lancet Planetary Health (2018)

On Dec 5, the UN Environment Programme launched the Frontiers report, which examined the interconnection between antimicrobial resistance and the natural environment. Without doubt, antibiotics have had a positive effect on our lives and unsurprisingly the demand for antibiotics has risen enormously in the recent years. Between 2000 and 2010, total global antibiotics consumption increased by 36% and today they are widely used to prevent and treat bacterial infections in humans and animals. They are also used in animal husbandry to increase meat production, although such practice has been banned since 2006.
Pasteurella multocida infection of a prosthetic vascular graft
Authors: S. B. Kalish
Journal: JAMA (1983)

THE INCIDENCE of vascular graft infections is reported to range from 0.25% to 6.0%, with<i>Staphylococcus aureus</i>as the most frequently isolated microorganism.<sup>1</sup><i>Pasteurella multocida</i>is a nonmotile, gram-negative pleomorphic coccobacillus that has been encountered in a wide variety of infections. It is a common cause of disease in veterinary medicine and also is being reported with increasing frequency as a cause of human infection.<sup>2,3</sup>The following report describes what we believe is the first reported case of vascular graft infection with P multocida. <h3>Report of a Case</h3> A 61-year-old man was admitted to the hospital in September 1981, complaining of malaise, fever, chills, and groin pain on the right side. The patient had atherosclerotic peripheral vascular disease and, in 1970, underwent revascularization with an aortobifemoral bypass graft. He was well until July 1981, when he experienced a false aneurysm of the left femoral graft, with total occlusion
Lipids, Malnutrition &amp;amp; the Developing Brain.
Journal: Annals of Internal Medicine (1973)

Book Notices1 February 1973Lipids, Malnutrition & the Developing Brain.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-2-330_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractAbstractSixteen papers from a meeting held in London, 19-21 October 1971. These reviews of current and recent work focus on improper nutrition as a critical determinant in central nervous system structure and the implications extend to genetic diseases, psychological and emotional maldevelopment, nutrition in poor countries, and evaluation of intelligence. Clearly a source that should be in all clinical libraries used by internists, pediatricians, psychiatrists, nutritionists, and biochemists with investigational interests in these directions. Subject index. This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1973Volume 78, Issue 2Page: 330-330KeywordsBrainCentral nervous systemChild psychiatryEmotionsGenetic diseasesIntelligenceLibrariesLipidsMalnutritionNutrition ePublished: 1 December 2008 Issue Published: 1 February 1973 PDF downloadLoading ...
THE ATTACK ON THE MEDICAL ADMINISTRATION OF THE PENSION BUREAU.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cost-Effective Treatment of Candida Esophagitis
Authors: Jill L. Legg
Journal: Annals of Internal Medicine (1993)

Letters15 May 1993Cost-Effective Treatment of Candida EsophagitisJill L. Legg, MD, Kirsten A. Brossier, MD, and Ronald H. Goldschmidt, MDJill L. Legg, MDSearch for more papers by this author, Kirsten A. Brossier, MDSearch for more papers by this author, and Ronald H. Goldschmidt, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-10-199305150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We are troubled by the conclusions of Laine and colleagues [1] that fluconazole is more effective than ketoconazole in treating candida esophagitis. Factors other than drug efficacy might explain the better response to fluconazole.Drug resistance may have accounted for some of the difference in response. Nearly half of the patients in both groups had been treated with antifungal therapy during the previous 3 months (26% with ketoconazole; 0% with fluconazole). The reasons for previous antifungal treatment were not given, nor is it mentioned whether ketoconazole use was equally distributed between the two groups. When the analysis ...REFERENCE1. Saag MS, Dismukes WE. Azole antifungal agents: emphasis on new triazoles. Antimicrob Agents Chemother. 1988; 32:1-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1993Volume 118, Issue 10Page: 824-825KeywordsAIDSAntifungalsCandidaDrug absorptionDrugs Issue Published: 15 May 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sequence analysis of a new RNA virus (hepatitis G virus, HGV) reveals a unique virus in the flaviviridae family . Genelabs Technologies, Inc., Redwood City, CA
Journal: Hepatology (1995)

Pseudostellariae Radix is an important traditional Chinese medicine (TCM), which is consumed commonly for its positive health effects. However, a lack of transcriptomic and genomic information hinders research on Pseudostellariae Radix. Here, high-throughput RNA sequencing (RNA-seq) was employed for the de novo assembly to analyze the transcriptome in Pseudostellariae Radix, finding significantly differentially expressed genes in this TCM from different fields based on RNA-seq and bioinformatic analysis. A total of 146,408,539 paired-end reads were generated and assembled into 89,857 unigenes with an average length of 862 bp. All of the assembly unigenes were annotated by running BLASTx and BLASTn similarity searches on the Non-redundant nucleotide database (NT), the Non-redundant protein database (NR), Swiss-Prot, Cluster of Orthologous Groups (COG), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and Interpro. On the basis of bioinformatic analysis and the expression profiles for Pseudostellariae Radix, 29 significantly differentially expressed genes were identified, which provides the basic information for exploring the molecular mechanisms that determine the quality of Pseudostellariae Radix from different fields. The expression levels of 29 genes were validated by real-time quantitative PCR (RT-qPCR). This is the first study to sample Pseudostellariae Radix, which provides an invaluable resource for understanding the genome of this herb.
Helicobacter pylori Prevalences and Risk Factors among School Beginners in a German Urban Center and Its Rural County
Authors: Olf Herbarth, Peter Krumbiegel, Gisela J. Fritz, Matthias Richter, Uwe Schlink, Detlef M. Muller, Thomas Richter
Journal: Environmental Health Perspectives (2001)

In 1998, the Helicobacter pylori [(13)C]urea breath test was offered to all school beginners (birth cohort 1991/1992) in the city of Leipzig and in Leipzig County, Germany, to determine the colonization prevalence and potential transmission pathways of the bacterium. A total of 3,347 school beginners participated in the test, and 2,888 parents completed the detailed, self-administered questionnaire. The H. pylori prevalence was 6.5% [95% confidence interval (CI), 5.3-7.6] in the city and 5.7% (CI, 4.2-7.0) in the county. Using cluster analysis (WARD's method, Euclidean distances), we identified different sets of variables (confirmed by multivariate logistic regression analyses [odds ratios (ORs)] that are signficantly associated with H. pylori positivity. Among city children, the risk is significantly increased with contact to a pet hamster (OR = 2.4; 95% CI, 1.2-4.7; p < 0.015) and travels to Asian countries (OR = 3.7; 95% CI, 1.6-8.7; p < 0.002). Among county children, H. pylori positivity increased significantly with drinking of water from nonmunicipal sources (OR = 16.4; 95% CI, 3.1-88.5; p < 0.001), more than 3 children living in a household (OR = 4.2; 95% CI, 1.2-14.6; p < 0.02), and contact with pet hamsters (OR = 2.4; 95% CI, 1.0-5.7; p < 0.04). These data suggest that, in a general population sample, indirect fecal-oral transmission and living conditions are important risk factors in the spread of H. pylori infection. However, clinical symptoms do not necessarily indicate H. pylori positivity.
Local Targeting of NAD+ Salvage Pathway Alters the Immune Tumor Microenvironment and Enhances Checkpoint Immunotherapy in Glioblastoma
Authors: Ming Li, Ameya R. Kirtane, Juri Kiyokawa, Hiroaki Nagashima, Aaron Lopes, Zain A. Tirmizi, Christine K. Lee, Giovanni Traverso, Daniel P. Cahill, Hiroaki Wakimoto
Journal: Cancer Research (2020)

Abstract The aggressive primary brain tumor glioblastoma (GBM) is characterized by aberrant metabolism that fuels its malignant phenotype. Diverse genetic subtypes of malignant glioma are sensitive to selective inhibition of the NAD+ salvage pathway enzyme nicotinamide phosphoribosyltransferase (NAMPT). However, the potential impact of NAD+ depletion on the brain tumor microenvironment has not been elaborated. In addition, systemic toxicity of NAMPT inhibition remains a significant concern. Here we show that microparticle-mediated intratumoral delivery of NAMPT inhibitor GMX1778 induces specific immunologic changes in the tumor microenvironment of murine GBM, characterized by upregulation of immune checkpoint PD-L1, recruitment of CD3+, CD4+, and CD8+ T cells, and reduction of M2-polarized immunosuppressive macrophages. NAD+ depletion and autophagy induced by NAMPT inhibitors mediated the upregulation of PD-L1 transcripts and cell surface protein levels in GBM cells. NAMPT inhibitor modulation of the tumor immune microenvironment was therefore combined with PD-1 checkpoint blockade in vivo, significantly increasing the survival of GBM-bearing animals. Thus, the therapeutic impacts of NAMPT inhibition extended beyond neoplastic cells, shaping surrounding immune effectors. Microparticle delivery and release of NAMPT inhibitor at the tumor site offers a safe and robust means to alter an immune tumor microenvironment that could potentiate checkpoint immunotherapy for glioblastoma. Significance: Microparticle-mediated local inhibition of NAMPT modulates the tumor immune microenvironment and acts cooperatively with anti-PD-1 checkpoint blockade, offering a combination immunotherapy strategy for the treatment of GBM.
A Dictionary of Medical Diagnosis.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bunions: New Look at an Old Problem
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thyroid crisis and the law
Authors: B. J. Ficarra
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The case reported by Dr. Ficarra (<b>208</b>:695, 1969), raises several questions which were not answered by his comments. It is perfectly true that the possibility of a thyroid crisis is something which should not be neglected in every patient who has thyroid surgery. Its occurrence is exceedingly rare, however, when the patient has been properly prepared for surgery by the preoperative administration of iodine. It was not stated in the case history whether this patient had been prepared with iodine or not. It was apparent from the statement that cardiac massage was performed during the second operative procedure and that a cardiac arrest had occurred. This raises the possibility that the subsequent course after the operation and the patient's death were due to irreversible brain damage which took place during the period of cardiac arrest, rather than to a thyroid crisis. It is true that the
THE CAUSE OF THE REDUCTION IN THE DEATH RATE FROM PHTHISIS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemical Reactions of Organic Compounds on Clay Surfaces
Authors: Yuko Soma, Mitsuyuki Soma
Journal: Environmental Health Perspectives (1989)

Chemical reactions of organic compounds including pesticides at the interlayer and exterior surfaces of clay minerals and with soil organic matter are reviewed. Representative reactions under moderate conditions possibly occurring in natural soils are described. Attempts have been made to clarify the importance of the chemical nature of molecules, their structures and their functional groups, and the Brönsted or Lewis acidity of clay minerals.
Internal Medicine
Authors: Frank D. Gray
Journal: JAMA (1987)

The traditional textbook of medicine is composed of discourses on the etiology, epidemiology, diagnosis, prognosis, course, and treatment of diseases, and the matrix that holds these elements together is pathophysiology. Pathophysiology reflects structural and functional patterns of adaptation and homeostasis formed by the exigencies of our daily lives. The traditional textbook relates diseases to biochemistry and physiology, enabling readers to cope with today's clinical problems and to prepare for the emerging ideas underlying medicine of the future. The ideal textbook also ought to give students the confidence to care for patients even when no hope for cure exists and to deal with the social and emotional influences that may lead to functional impairment when there is no discernible physical disease. Does the second edition of Stein's<i>Internal Medicine</i>fulfill this description? Generally it does. The presentation is authoritative, and the understanding of pathophysiological processes is accorded as much importance as
Protozoology: A Manual for Medical Men, Veterinarians and Zoologists. In two volumes.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Department of Public Health
Authors: Herbert L. Lombard
Journal: New England Journal of Medicine (1951)

FIELD TRAINING FOR PUBLIC-HEALTH PERSONNELMassachusetts can claim another "first" in the field of progressive public-health practice. The American Medical Association has approved a specialty board in Preventive Medicine and Public Health, and Massachusetts has been selected as one of the ten states in which the supervised field-training portion of accredited residency may be taken by qualified physicians.Field training is not something separate from, or a competitor of, academic instruction, but rather supplements and complements classroom and laboratory instruction. Field training is to public-health education what the internship is to medical education. Residency programs must be sufficiently broad in . . .
International Clinics. A Quarterly of Illustrated Clinical Lectures and Especially Prepared Original Articles on Treatment, Medicine. Surgery, Neurology, Pediatrics. Obstetrics. Gynecology, Orthopedics, Pathology, Dermatology. Ophthalmology. Otology, Rhinology, Laryngology, Hygiene and Other Topics of Interest to Students and Practitioners. By Leading Members of the Medical Profession Throughout the World.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal