tbuckley/cabot-search huggingface dataset:
Neonatal Meningitis
Authors: Mohsen Ziai, Robert J. Haggerty
Journal: New England Journal of Medicine (1958)

MENINGITIS during the first month of life is a rare disease. When it occurs, however, early diagnosis is difficult, therapy is uncertain, and the prognosis is still generally stated to be poor.1 , 2 The literature on this subject began with Macaigne's3 case report in 1873 and was followed in the next seventy years by only a few reports of single cases or small series of cases.4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 In 1943 Flensborg19 was able to gather only 131 cases from the world literature. Debré, Mozziconacci and Berkman,1 in 1954, reviewed 33 cases from the more recent literature, together with 13 of their own cases . . .
Survival outcome of E1201: An Eastern Cooperative Oncology Group (ECOG) randomized phase II trial of neoadjuvant preoperative paclitaxel/cisplatin/radiotherapy (RT) or irinotecan/cisplatin/RT in endoscopy with ultrasound (EUS) staged esophageal adenocarcinoma
Authors: L. Kleinberg, M. E. Powell, A. A. Forastiere, S. Keller, P. Anne, A. B. Benson
Journal: Journal of Clinical Oncology (2008)

4532 Background: E1201 included operable esophageal adenocarcinoma, staged II-IVa by EUS. The primary endpoint was pathologic complete response (pCR), a surrogate endpoint generally associated with survival. Previously reported pCr rates indicated that these regimens did not meet criteria for further study based on a target of 45% against the null hypothesis of 25% for standard therapy. Sufficient follow-up is now available to report survival outcome. Methods: 86 eligible pts began treatment. Arm A was cisplatin (C) 30mg/m2 and irinotecan (I) 50 mg/m2 on days (d) 1, 8, 22, 29 of 45 Gy RT/5 weeks. Post-op therapy was C 30 mg/m2 and I 65 mg/m2 d 1, 8 q21 days x 3. Arm B therapy was C 30 mg/m2 and paclitaxel (P) 50 mg/m2 1 hour infusion d 1, 8, 15, 22, 29 with RT. Postoperative therapy was C 75 mg/m2 and P 175 mg/m2 day 1 q21 days x 3. Previously reported pCR was 14% for arm A (95% CI [5.5%, 28.5%]) and 16% (95% CI [6.7%, 30.1%]) for arm B. Results: Twenty-two of the 42 eligible and treated patients in Arm A are known to have died. Median survival in Arm A is 34.9 m (months) with a 90% CI of [23.5, NR]. In Arm B, 27 of the 44 eligible and treated patients are known to have died, with one patient having refused follow-up. Median survival in Arm B is 20.9 m with a 90% CI of [17.4, 46.7]. The outcome for the treatment arms was similar. Survival was also assessed by EUS strata. Eleven of the 21 eligible and treated patients in stage stratum one (Stages T2N0M0 or T3N0M0) are known to have died. Median survival in stage stratum one is 36.5 m with a 90% CI of [20.5, NR]. In stage stratum two (Stages T1–3N1M0 or T1–3N0-1M1a), 38 of the 65 eligible and treated patients are known to have died. Median survival is 26.0 m with a 90% CI of [19.9, 46.7]. Within each stage strata, there did not appear to be any meaningful response and survival differences by treatment arm. Conclusions: Survival is similar for both treatment arms and does not appear superior to results achieved in other trials with rigorous pretreatment staging. Neither regimen appears likely to advance treatment of esophageal/GEJ adenoca over preoperative cisplatin/5-FU/RT. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Amgen, Bristol-Myers Squibb, Pfizer, sanofi-aventis Amgen, AstraZeneca Oncology, Bristol-Myers Squibb, Pfizer
The Apologie and Treatise of Ambroise Paré Containing the Voyages Made into Divers Places with Many of His Writings upon Surgery.
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROGRAM OF THE FIFTY-FIFTH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, INC., TO BE HELD IN ATLANTIC CITY, NEW JERSEY, APRIL 29, 1963
Authors: Replication Kikuchi, Avery Sandberg, T Couch, R Cate, Homograft Survival, Alexander Fefer, William Davis, Walter Norton, Mor- Ris Ziff
Journal: Journal of Clinical Investigation (1963)
Undergraduate Medical Education
Authors: Harry S. Jonas
Journal: JAMA (1989)

<h3>INTRODUCTION</h3> The decade of the 1980s continues to be marked by significant societal changes that have an impact on American medical education. Foremost among the trends has been the declining number of applicants to US medical schools. Undergraduate medical education faces enormous challenges as the pressures for accountability by the profession mount. Not only must medical educators respond to the rapidly expanding knowledge base in the biomedical sciences, but they must balance that with the charge of training physicians who will spend more time with their patients and demonstrate compassion and caring. New methods of health care delivery, shorter hospital stays, and the ascendancy of the ambulatory care setting have all created a need for reexamination of the methodology and the settings that can best be employed for teaching medical students. Challenges such as the acquired immunodeficiency syndrome epidemic, the continued pressures of professional liability, and demands for better supervision
Book Review An Introduction to Medical Science . By William Boyd, M.D., M.R.C.P. (Edin.), F.R.C.P. (Lond.), F.R.S. (Canada). Second edition, thoroughly revised. 8°, cloth, 358 pp., with 124 illustrations. Philadelphia: Lea and Febiger, 1941. $3.50.
Journal: New England Journal of Medicine (1942)
The common cold. Cold water on hot news
Authors: A. S. Monto
Journal: JAMA (1994)

The common cold has long been recognized as the acute condition most frequently affecting individuals of all ages.<sup>1</sup>In several community-based studies, the illness frequency ranged between four and six episodes per year in children aged 5 to 9 years and from three to five episodes in young adults, with higher rates in those living in crowded conditions or mothers exposed to young children.<sup>2,3</sup>Median duration varied from 7 to 13 days, in part dependent on age.<sup>4,5</sup>Given the frequency and duration of these illnesses it is not surprising that considerable public attention has been directed to their treatment. The expression "finding a cure for the common cold" has been heard frequently in the media. Identifying etiology was the first approach taken by the scientific community. Rhinoviruses were the agents most frequently isolated from persons with common colds, and their predominance became more apparent as techniques for
The Platelet
Authors: Robert T. Breckenridge
Journal: JAMA (1972)

This book is one of a series of<i>Monographs in Pathology</i>and the result of a series of papers presented at the 58th annual meeting of the International Academy of Pathology in San Francisco. The editors have outdone themselves in producing this fine monograph. Certainly the distinguished list of authors, each expert in his particular field of platelet physiology, makes this book a successful contribution to the hemostatic literature. This particular reader was very impressed by the fact that the editors have written a final chapter summarizing all of the previous contributions and have added footnotes to call attention to differences between different points of view. It appears that the platelet is finally receiving the attention it so richly deserves, and any serious student of hemostasis will be obligated to refer to this impressive monograph as source material. The somewhat high price may keep all of us from purchasing this
Allergy and immunology
Authors: C. Cunningham-Rundles
Journal: JAMA (1995)

Cytokines are low-molecular-weight proteins secreted by many cells, which can function as immune mediators. (If the cell of origin is a lymphocyte, these proteins are usually called lymphokines.) Many cytokines were originally named on the basis of an observed biological activity (eg, tumor necrosis factor and interferon), but most are multifunctional and act on a variety of target cells. These hormonelike compounds are capable of a wide range of immunologic activities, including either stimulating or suppressing various cells of the immune system. Despite the powerful in vitro activities of cytokines and the demonstration of increased levels of cytokines in tissues, serum, or other biological fluids, the role of cytokines in the pathogenesis of disease remains unknown but intensely investigated.<sup>1</sup> One of the major controversies about assigning cytokines a role in disease pathogenesis is that there are still many questions about the optimum methods for measuring individual cytokines. The most
Future Articles
Journal: Journal of the American Society of Nephrology (2006)

### The Genetics of Kidneys in Diabetes (GoKinD) Study: A Genetics Collection Available for Identifying the Genetic Susceptibility Factors for Diabetic Nephropathy in Type 1 Diabetes Mellitus Patricia W. Mueller, John J. Rogus, Patricia A. Cleary, Yuan Zhao, Adam M. Smiles, Michael W. Steffes, Jean
ICCCR Suddenly Dismantles Operations
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article ICCCR Suddenly Dismantles Operations Get access JNCI: Journal of the National Cancer Institute, Volume 84, Issue 14, 15 July 1992, Page 1068, https://doi.org/10.1093/jnci/84.14.1068-a Published: 15 July 1992
Amyloid Deposits and Amyloidosis
Authors: George G. Glenner
Journal: New England Journal of Medicine (1980)

Redefinition of Amyloid Fibrils and Classification of the β-FibrillosesThe diversity of the major protein component of amyloid fibrils from classically accepted sites of amyloid deposition negates the unitary concept that all amyloid proteins are derived from a single source and of the same nature. Although this chemical heterogeneity of amyloid and the generic basis of the term was predicted before the definitive chemical data were presented,29, 119 the great variation subsequently found was not anticipated.6 The amyloid fibril, the abortive effort of the vertebrate to rival the silkworm, represents the final common pathway for a diverse array of proteins in . . .
THE GLOVER CANCER SERUM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Several Theories of Cancer Spread Challenged
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4211: Breast cancer risk factors by mode of detection among screened women in the Cancer Prevention Study-II
Authors: Mia M. Gaudet, Emily Deubler, W. Ryan Diver, Samantha Puvanesarajah, Alpa V. Patel, Ted Gansler, Dana Flanders, Mark Sherman, Susan Gapstur
Journal: Cancer Research (2019)

Abstract Identifying risk factors for women at high risk of symptom-detected breast cancers that were missed by screening would enable targeting of alternative prevention strategies. To identify breast cancer risk factors by mode of detection, we examined these associations in heavily-screened women from the Cancer Prevention Study (CPS)-II Nutrition Cohort. Among 76,406 women followed for a median of 13.8 years, 2,469 screen-detected and 1,189 symptom-detected breast cancer cases were diagnosed. Multivariable-adjusted associations were estimated using joint Cox proportional hazards regression models with person-time calculated contingent on screening. The mean (standard deviation) age at baseline was 62.0 (6.6) years for non-cases, 61.6 (6.1) for screen-detected cases, and 61.5 (6.2) for symptom-detected cases. Women with symptom-detected tumors were diagnosed at a slightly younger age (mean=69.4) and less likely to be diagnosed with a localized tumor (65.3%), than women with a screen-detected tumor (mean age at diagnosis=70.4 and localized tumors=83.3%). Factors associated with higher risks of symptom detected vs. screen detected breast cancer, included: current combined menopausal hormone use (HR=2.04, 95% CI 1.70 - 2.46 vs. HR=1.43, 95% CI 1.25 - 1.63), current estrogen only menopausal hormone use (HR=1.41, 95% CI 1.15 - 1.72 vs. HR=0.94, 95% CI 0.82 - 1.09), and history of benign breast disease (HR=1.89, 95% CI 1.67 - 2.13 vs. HR=1.49, 95% CI 1.36 - 1.62). The opposite pattern of higher risk of screen detected vs. symptom detected breast cancer was observed for greater adult weight gain (HR=2.32, 95% CI 1.91 - 2.82 vs. HR=1.42, 95% CI 1.10 - 1.84) and alcohol intake (HR=1.39, 95% CI 1.24 - 1.64 vs. HR=1.20, 95% CI 0.92 - 1.58). Our results suggest that understanding risk factors for symptom-detected cancers may help identify women who would benefit from more intensive screening to facilitate early detection. Citation Format: Mia M. Gaudet, Emily Deubler, W. Ryan Diver, Samantha Puvanesarajah, Alpa V. Patel, Ted Gansler, Dana Flanders, Mark Sherman, Susan Gapstur. Breast cancer risk factors by mode of detection among screened women in the Cancer Prevention Study-II [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4211.
Analysis of relationship between baseline body weight and efficacy/safety of yttrium 90 (90Y) ibritumomab tiuxetan radioimmunotherapy in patients (pts) with non-Hodgkin's lymphoma (NHL)
Authors: G. A. Wiseman, C. Emmanouilides, K. Vo, R. J. Schilder, P. Foster, L. I. Gordon, T. E. Witzig, A. Molina
Journal: Journal of Clinical Oncology (2004)

6700
Surveillance for Occupational Lead Exposure—United States, 1987
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The future course of AIDS in the United States
Authors: M. Morgan
Journal: JAMA (1990)

In recent years, many individuals have developed models to predict the future course of the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) epidemic at the local, state, and national levels. The number of forecasters and resulting projections reflects not only the complexity and uncertainties in predicting the epidemic, but also the critical importance of such estimates.<sup>1</sup>Many health care policies are based on these forecasts, which influence the scope and direction of both public and private initiatives related to HIV. Overall, the number of reported cases of AIDS in the United States continues to increase. During 1989, 35 238 cases were reported, for a yearly increase of 9.4% over the 32 196 cases reported during 1988. This increase is lower than in past years, partly because of the large number of previously diagnosed cases reported in 1988 that met only the expanded AIDS case definition.<sup>2</sup>However, even after
JAMA Cardiology
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Iris Lo, Kevin Brown, Amanda Ehrhardt, M Newman, Suzanne Walker, Connie Manno Senior, Sara Billings, Timothy Gray, Juliet Orellana, Paul Ruich, Kirby Snell, Catherine Alden, Stephanie Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Bernadette Hromin, Paul Jaworski, Laura King, Regina Lilly, Jenny Mackay, Molly O'donnell, Charon Pierson, Thressa Smith, Divya Sreekumar, Annette Theuring, Donna Thordsen, Christine Tilles, Caroline Woods, Editorial Assistant, Wanda Hill, Larry Bryant, Jacob Kendall-Taylor, Monica Managers, Fanny Staff, Anna Brown, Lee Bukowski, Lenette Calibeo, Tosca Gardner-Gullens, Erin Hall, Rachell Kato, Kenneth Lozano, Caroline Otani, Angelia Sietmann, Michael Berkwits, Eric Butkus, Jesse Mcquarters, Elena Guobyte, Emily Ling, Daniel Morrow, Social Media, Eman Hassaballa, Reuben Rios, Mary Ferkaluk, Karen Bucher, Andy Rekito, Nick Reback, Lohitha Kethu, David Song, Deputy Livingston, Thomas Cole, Administration Director, Marla Jeff, Deanna Willis, Yolanda Davis, Joseph Thornton, Deanna Bellandi, Jim Periodical, Thomas Easley, Brian Shields, Karen Adams-Taylor, Paul Gee, Monica Smith, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara, Annissa Zak, Circulation Services, Julie Burton, Ronna Hewitt, Mary Sieck, Geneine Someren, Jamaal Vargas, Mike Bujewski, Nathan Mitre, Digital Production, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Dan Knowles, Joshua Lampinen, Natalie Marsh, Patricia Panek, Marla Seidell, La Son, Diggs Sledge, Julian Graphics, Joe Amft, James Collver, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Maria Giannini, Sasha Grossman, Judith Literskis, Teresa Omiotek, Michael Ryder, James Madara, Howard Bauchner, Robert Bonow, Patrick O'gara, Marc Sabatine, Clyde Boston, Michael Pencina, Carolina North, Adrian Hernandez, Mhs Durham, North Carolina, Mark Huff Man, Ajay Kirtane, New York, Roxana Mehran, Ann Navar, Carolina Christopher, J O'donnell, Massachusetts Boston, J Sanjiv, Mintu Shah, Gregg Fonarow, Los Angeles, Elizabeth Mcnally, Laine Thomas, Akhil Narang, Julia Getts, Eugene Braunwald, Robert Califf, Judith Hochman, Donald Lloyd-Jones, Scm Chicago, Michael Parmacek, Daniel Simon, Sidney Smith, Chapel Hill, Carolina Douglas, E Vaughan, Myron Weisfeldt, Maryland Douglas, P Zipes, Paul Armstrong, Shinya Goto, Peter Liu, Renato Lopes, Carolina Maseri, Dorairaj Prabhakaran, Hugh Watkins, Harvey White, Habib Yacoub
Journal: JAMA Cardiology (2020)
End-stage diabetic nephropathy.
Journal: BMJ (1978)

End-stage diabetic nephropathyChronic renal failure has become the leading cause of death in juvenile-onset diabetes; it now accounts for half of all deaths' in patients who develop their diabetes before the age of 20.The earliest clinical feature of the disease is symptomless proteinuria, which is sometimes intermittent and separated by weeks or months of negative test results.The mean duration of diabetes before the onset of proteinuria is about 15 years.Once the condition is detected, life expectancy varies con- siderably: the mean is five years but some patients survive as long as 18 years.2-4The prognosis for renal function is equally variable, so that mild impairment may persist for some months or even years without further deterioration.Once the decline in function accelerates, however, renal failure usually develops rapidly and inexorably.Most patients die within two years' of developing a persistent blood urea concentration of 10 mmol l.The cause of this rapid terminal deterioration is unknown, but its recognition is important in planning the management of diabetic patients with advancing renal failure.The diabetic with end-stage renal failure faces the same choices as does the non-diabetic uraemic patient: maintenance haemodialysis, maintenance peritoneal dialysis, and renal transplantation.Reports of the results with maintenance dialysis are difficult to compare, but, in general terms, in diabetic patients survival rates for the first, second, and third years are about 610,, 4800, and 3100 respectively, while the corresponding figures in non-diabetics are 930 , 820,1 and