tbuckley/cabot-search huggingface dataset:
Knot
Authors: David J Einstein
Journal: Annals of Internal Medicine (2012)

On Being a Doctor4 September 2012KnotDavid J. Einstein, MDDavid J. Einstein, MDFrom Tufts Medical Center, Boston, MA 02111.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-5-201209040-00012 Audio Reading - “Knot” Audio. Listen to a reading of "Knot" by David J. Einstein, MD. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “You can tie?” a middle-aged, Cantonese-speaking woman asked me, holding out a blue repp-stripe necktie. I was finishing putting in orders after Sunday morning rounds on the oncology service.Turning away from the computer and my pile of scribbled notes, I was puzzled by her request but responded that I could indeed help her with the tie. I followed her from my computer station back to a darkened patient room. As I followed, I realized that she was one of several members of an extended family gathered beside my patient.I had met Mr. Y. that morning on rounds after ... Author, Article, and Disclosure InformationAuthors: David J. Einstein, MDAffiliations: From Tufts Medical Center, Boston, MA 02111.Corresponding Author: David J. Einstein, MD, Tufts Medical Center, 800 Washington Street, Boston, MA 02111; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Knot” Audio. Listen to a reading of "Knot" by David J. Einstein, MD. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 4 September 2012Volume 157, Issue 5Page: 381-382KeywordsBreathingComputersMorphineOxygenPancreatic cancerPatientsRiversShouldersStomachWeight loss ePublished: 4 September 2012 Issue Published: 4 September 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Neuropsychopharmacology and the Affective Disorders
Authors: Joseph J. Schildkraut
Journal: New England Journal of Medicine (1969)

Neuropharmacologic Studies of Drugs Used in the Affective DisordersSince the initial observation that reserpine, a drug that could cause depression in some patients, depletes the brain of various biogenic amines in animals, whereas the monoamine oxidase inhibitor antidepressants increase levels of biogenic amines in the central nervous system, the effects of these and other psychoactive drugs on biogenic amine metabolism have been extensively studied. The catecholamines, norepinephrine and dopamine, and the indoleamine, serotonin, are the brain monoamines that have received the greatest attention. Norepinephrine is present in many areas of the brain, but it is most highly concentrated in . . .
Tablet Available, But Not Recommended
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Son
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiple Myeloma
Authors: Jacob Laubach, Paul Richardson, Kenneth Anderson
Journal: Annual Review of Medicine (2010)

Multiple myeloma (MM) is a B cell neoplasm of the bone marrow with a complex array of clinical manifestations including anemia, bone lesions, hypercalcemia, renal dysfunction, and compromised immune function. It accounts for 10%-15% of all hematologic malignancies, and 20% of deaths related to cancers of the blood and bone marrow. The diagnosis of MM is based on the presence of neoplastic plasma cells in the bone marrow or other extramedullary sites, along with evidence of disease-related organ dysfunction. Although the disease remains incurable, significant advances in both basic and translational research have enhanced understanding of disease pathogenesis and guided the development of new and more effective therapies. These agents include the immunomodulatory drugs thalidomide and lenalidomide, the proteasome inhibitor bortezomib, and other therapeutics that are currently being evaluated. This review highlights important historical landmarks in the field of MM, examines the pathogenesis and clinical manifestations of the disease, and outlines principles of both diagnosis and treatment of MM.
The Danger of Wearing an Anorak
Authors: Chui M G Cheung, Omar M Durrani, Ming S Lim, Mahesh Ramchandani, Somnath Banerjee, Philip I Murray
Journal: Journal of the Royal Society of Medicine (2002)

Campaigns to reduce road traffic accidents have paid little attention to the way headgear could interfere with vision. Binocular visual field measurement was undertaken in six healthy volunteers wearing four different types of anorak. All four anoraks greatly reduced the horizontal and superior field of vision. The anorak producing the worst reduction resulted in a width of vision of 99 degrees and only 15 degrees of vision above eye level, versus 167 degrees and 52 degrees respectively without an anorak. Anorak wearers should turn their heads to look sideways before crossing the road.
A shot in the dark
Authors: J. J. Littell
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Nature's bony defenses saved the life of a woman who attempted suicide by shooting herself through the open mouth. She was at once relieved of the cause of her depression. <h3>Report of a Case:—</h3> This 35-year-old woman, in a burst of despondency over ill health, attempted suicide by shooting herself through the open mouth with a. 22-caliber revolver. Her purpose was not immediately accomplished. She regretted her impulse. X-ray films (Fig 1 and 2), taken immediately, revealed the bullet in the right sphenoid sinus, flattened against the sinus roof. The following morning with the patient under local anesthesia, I took down the anterior sinus wall and encountered a cavity full of pus. The bullet was located, firmly embedded in the roof. I grasped it with appropriate forceps and with a rocking motion, freed and removed it. It came out with a sucking sound as if one were pulling
RELATION BETWEEN HEART DISEASE AND EPILEPSY.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Residential Exposure to Plasticizers and Its Possible Role in the Pathogenesis of Asthma
Authors: Leif Oie, Lars-Georg Hersoug, Jorgen Ogaard Madsen
Journal: Environmental Health Perspectives (1997)

The plasticizer di(2-ethylhexyl) phthalate (DEHP) is widely used in building materials. DEHP is identified as the major plasticizer exposure in dwellings. We provide evidence that inhalation exposure to DEHP as aerosols adsorbed to particulate matter is as important, or more important, than vapor phase exposure. The particulate inhalation exposure to DEHP is considered to be significant due to its low clearance and extensive penetration into the pulmonary region. DEHP is capable of creating high local concentrations in the airways at the deposition site with subsequent local effects. The proposed mechanism of effect states that mono(2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD(2), 9alpha,11betaPGF2, and PGF2alpha, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.
THE FEMALE NURSE IN THE ARMY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antidiuretic Hormone
Authors: Howard L. Bleich, Emily S. Boro, Richard M. Hays
Journal: New England Journal of Medicine (1976)

A few years ago, a teacher who was planning a course in physiology might have allowed an hour to cover the action of antidiuretic hormone. This would have been a reasonable allotment of time; the topic seemed simple and straightforward, especially in comparison to the complex actions of thyroid hormone or the adrenal steroids. Today, this situation has changed; the available information about antidiuretic hormone has increased dramatically, partly because of advances in neurophysiology, partly because of the development of radioimmunoassay technics, and perhaps mostly because of the brilliant contributions of Sutherland and his colleagues in the area of cyclic-AMP . . .
Sources, Transport and Alterations of Metal Compounds: An Overview. I. Arsenic, Beryllium, Cadmium, Chromium, and Nickel
Authors: Lawrence Fishbein
Journal: Environmental Health Perspectives (1981)

An overview is presented of the current state of knowledge of the salient aspects of the sources, transport, and alterations of arsenic, beryllium, cadmium, chromium, and nickel. This information is considered vital for a better assessment of the scope of potential human hazard to these ubiquitous toxicants and their compounds. Stress is focused on both natural and industrial activities, particularly on the latter's projected trends. Increasing use patterns per se of most of these metals, as well as aspects of waste disposal and the anticipated increased combustion of fossil fuels for power generation and space heating (particularly in the United States), are major causes of potential health concern. Additionally, attention is drawn to the need for increased research to fill the gaps in our knowledge in these vital areas, all in the hope of permitting a more facile identification and quantification of the potential hazard to exposure to these agents.
Papillomavirus in the vapor of carbon dioxide laser-treated verrucae
Authors: J. M. Garden
Journal: JAMA (1988)

Vapor produced by the carbon dioxide laser during the vaporization of papillomavirus-infected verrucae was analyzed for viral DNA content. Two models were used for evaluation: an in vitro cutaneous bovine fibropapilloma and an in vivo human verruca model. Four bovine fibropapillomas were exposed to various laser parameters with power densities of 38200 to 130 W/cm<sup>2</sup>and energy fluences of 3820 to 130 J/cm<sup>2</sup>. The generated vapor was collected in a chamber in line with a vacuum system. Hybridization with bovine papillomavirus DNA probes revealed intact bovine papillomavirus DNA for all power densities and energy fluences used. The laser vapor from seven patients undergoing carbon dioxide laser therapy for plantar or mosaic verrucae was also collected. Laser parameter settings were similar to those usually chosen for clinical tissue vaporization. Intact human papillomavirus DNA was present in the vapor from two of seven patients. These studies indicate that intact viral DNA is liberated into the air with the vapor of laser-treated verrucae. It would be prudent for all practitioners who use the laser in treating patients with viral infections or conditions associated with viruses to practice extreme care and safety throughout the laser procedure. (<i>JAMA</i>1988;259:1199-1202)
Biological Monitoring of Polycyclic Aromatic Hydrocarbon Exposure in a Highly Polluted Area of Poland
Authors: Steinar Ovrebo, Per Einar Fjeldstad, Ewa Grzybowska, Elin Hegland Kure, Mieczyslaw Chorazy, Aage Haugen
Journal: Environmental Health Perspectives (1995)

Air pollution in Poland and p la in Silesia is among the worst in Europe.Many coal mines and coke oven plants are located in this area, o f polycydiaromatichydrocarbon (PAHs).:WWe qu ad PAM ep.l air smp using personal sampling devfic.acollected une apl frM" the nde: ii:, and sea aurad 1-hydroypyrene with h pe nce liq cSt s were collected twice, once in Ferary and once in Sete r.Mean PAH lve of samples collected at three diffcrent coke oven plants varied from 2.3 pgm3 to 12.3 pgm3; the lowest mean was in September.Mean leves of 0.15 plm3 (Sptember) and 0.44 pgm3 (Fbru ) wee noted for the environmentally exposd goup Mean u In variedMfromin 2.45 to 1348.pmol/mol c i at the three coke oven pat.rpondin i betwer th three different enomentalBy exp d groups in Silei was. 0.41-1.54ol/mol c ni In thie sonindustriuied area, the id ont 0 0.14 pmtne.Se variation w asf both at the cokoven plantIand groups iSieia.Both PAH evels and 1-hrxypyrene vaed son among oven workers and the evo enl* expoed group.Our study shows that PAH ecqpsre i the indusalized area of Sileint is hig to tls in Western -Hydrrypjt el;to in e ronmentaly exposed isndiv s inP land is am hge In-E .td air po tion, benzo[a]pyreneg, 1-hyd ypyrene, po clic
Sex and the practicing physician
Authors: W. F. Sheeley
Journal: JAMA (1966)

Since ancient times and before, people have turned to the family physician for help with problems affecting their sex lives. Although they may not say so unless he encourages them, they expect his help to understand the perplexing and often terrifying emotions which they feel in themselves and observe in others. Parents ask him to explain to an adolescent son "the facts of life" of which they themselves are not too sure even after years of marriage. Or the son himself haltingly asks the doctor to explain the alarming things going on in his body and in his thoughts. Couples bring to him problems blighting their marriage bed. Other people question him about fears that they are perverted, weak, or diseased. These sexual problems are often not as simple as they seem. They may be but the overt show of many hidden conflicts. The complexity of these problems is not
Texas Reports on Biology and Medicine, Galveston
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE HYPOTHETICAL QUESTION IN EXPERT TESTIMONY
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Restless legs syndrome. Sleep-electroencephalographic and neurologic findings
Authors: B. L. Frankel
Journal: JAMA (1974)

The unusual sensory and motor symptoms of the restless legs syndrome are described in general and as experienced by a 48-year-old woman with severe insomnia secondary to these symptoms. The neurologic evaluation of this patient showed definite evidence of motor neuron disease as reflected in abnormalities in the electromyogram, muscle biopsy specimen, and cerebrospinal fluid. (<i>JAMA</i>230:1302-1303, 1974)
Abstract 1422: Postconditioning Does Not Reduce Myocardial Infarct Size in an in-vivo Regional Ischemia Rodent Model
Authors: Joan Dow, Robert A Kloner
Journal: Circulation (2006)

Studies with stuttering reperfusion, postconditioning, consistently showed reductions of necrosis in isolated heart models. There are fewer studies that have examined the effect of postconditioning...
Strümpell-Seyfarth Lehrbuch der speziellen Pathologie und Therapie der inneren Krankheiten füf Studierende und Ärzte.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thrombolysis for Acute Stroke
Authors: Luigi Bozzao
Journal: JAMA (1996)

<h3>To the Editor.</h3> —We appreciate the thoughtful Editorial of Dr Fisher and colleagues<sup>1</sup>on ECASS.<sup>2</sup>Their question, "why experienced investigators misinterpreted so many initial CT scans," although provocative, addresses an important aspect of that trial. The ECASS protocol defined clinical and CT inclusion and exclusion criteria to be checked by the local investigators of 75 European study centers and stated that "a panel of 3 independent neuroradiologists will assess all CT scans centrally. It will function as final arbiter. They will double-check and identify eventual exclusion criteria as defined in 3.2 and assess intracranial hemorrhage as defined in Appendix 2." Local monitors gathered all CT scans for submission to the chairman of the CT-Scan Reading Panel who provided the other two members with copies. The members individually and consecutively evaluated all CT scans of the study blinded to any clinical information. The study protocol did not blind their