tbuckley/cabot-search huggingface dataset:
THE PHYSICIAN'S WIFE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer of the urogenital tract: bladder cancer. Group 3, stage D, grades 3 and IV: metastatic carcinomas
Authors: P. Rubin
Journal: JAMA (1969)

Palliation in advanced cancer (Introductory Figure) is mainly relief from distressing symptoms. Subjective improvement by any modality is not considered effective unless it is accompanied by some objective regression of the tumor. Treatment for stage D bladder cancer can give the patient benefit without always directly attacking the cancer. Major complaints are related to obstruction, infection, and hemorrhage, and each can be relieved by different maneuvers requiring either surgical treatment or radiotherapy. Diversion of the urinary stream is an important contribution to caring for this stage of bladder cancer; numerous means of accomplishing this task are available. The morbidity and mortality must be considered and depend upon the medical problems of the host. Often, diversion may be sufficient to provide symptomatic relief, but hemorrhage and infection may not be controlled without vigorous treatment. Jacobs presents his views on this topic. Irradiation for advanced cancer with intent to palliate may require
Outcome of lamivudine resistant hepatitis B virus infection in liver transplant recipients in Singapore
Authors: C T WAI
Journal: Gut (2001)

Editor,—We read with interest the article by Mutimer and colleagues ( Gut 2000;46:107–113[OpenUrl][1][Abstract/FREE Full Text][2]). The Birmingham group described the clinical course of four liver transplant patients who developed graft infection with lamivudine resistant virus. Lamivudine resistant hepatitis B developed after a mean … [1]: {openurl}?query=rft.jtitle%253DGut%26rft.stitle%253DGut%26rft.aulast%253DMutimer%26rft.auinit1%253DD%26rft.volume%253D46%26rft.issue%253D1%26rft.spage%253D107%26rft.epage%253D113%26rft.atitle%253DOutcome%2Bof%2Blamivudine%2Bresistant%2Bhepatitis%2BB%2Bvirus%2Binfection%2Bin%2Bthe%2Bliver%2Btransplant%2Brecipient%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fgut.46.1.107%26rft_id%253Dinfo%253Apmid%252F10601065%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=gutjnl&resid=46/1/107&atom=%2Fgutjnl%2F48%2F4%2F581.1.atom
Gender disparities in clinical decision making. Council on Ethical and Judicial Affairs, American Medical Association
Authors: Richard J. McMurray, Oscar W. Clarke, John A. Barrasso, Dexanne B. Clohan, Charles H. Epps, John Glasson, Robert McQuillan, Charles W. Plows, Michael A. Puzak, David Orentlicher, Kristen A. Halkola
Journal: JAMA (1991)

RECENT evidence has raised concerns that women are disadvantaged because of inadequate attention to the research, diagnosis, and treatment of women's health care problems. In 1985, the US Public Health Service's Task Force on Women's Health Issues reported that the lack of research data on women limited understanding of women's health needs.<sup>1</sup> One concern is that medical treatments for women are based on a male model, regardless of the fact that women may react differently to treatments than men or that some diseases manifest themselves differently in women than in men. The results of medical research on men are generalized to women without sufficient evidence of applicability to women.<sup>2-4</sup>For example, the original research on the prophylactic value of aspirin for coronary artery disease was derived almost exclusively from research on men, yet recommendations based on this research have been directed to
Physiology and Anatomy
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 517: Supraphysiological androgens activate innate immune signaling in prostate cancer
Authors: Janet Mendonca, Olutosin Owoyemi, Marc Rosen, Michael Carducci, Mark Markowski, Emmanuel Antonarakis, Drew Pardoll, Samuel Denmeade, Sushant K. Kachhap
Journal: Cancer Research (2019)

Abstract Castration resistance prostate cancer (CRPC) first manifests as a sustained rise in the androgen-responsive gene, PSA, consistent with reactivation of a functioning androgen receptor (AR) axis. This observation led to the development of “second-line” therapies aimed at further blocking androgen/AR signaling. Unfortunately, resistance to these agents can also develop quickly. Paradoxically, several studies have suggested that the growth of AR-positive human CRPC cell lines may be inhibited by supraphysiologic levels of testosterone (SupT). These studies suggested that the adaptive reliance on AR signaling by CRPC cells becomes a therapeutic liability that can be exploited through the administration of SupT, which we termed as bipolar androgen therapy (BAT). Understanding how BAT works at the molecular and cellular levels might help in rationally combining BAT with other agents to achieve increased efficacy and tumor responses. Our data indicates that SupT induces DNA double strand breaks (DSBs) in prostate cancer (PCa) cells. Unrepaired DSBs induced by SupT are routed for specialized autophagic degradation, termed nucleophagy. We further show that SupT-induced autophagosomal DNA can activate cytoplasmic DNA sensing pathways and downstream innate immune signaling. Based on our findings, we propose that BAT engages the immune system to inhibit tumor growth. Future combination of BAT with existing immunotherapeutics including immune checkpoint blockade may prove beneficial for treatment of CRPC. Citation Format: Janet Mendonca, Olutosin Owoyemi, Marc Rosen, Michael Carducci, Mark Markowski, Emmanuel Antonarakis, Drew Pardoll, Samuel Denmeade, Sushant K. Kachhap. Supraphysiological androgens activate innate immune signaling in prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 517.
ATTIRE: Albumin to prevent infection in chronic liver failure: an interventional randomised controlled trial
Authors: Louise China, Simon Skene, Nicholas Freemantle, Kate Bennett, Ekaterina Bordea, Natalia Becares, Andrew Portal, Yiannis Kallis, Gavin Wright, Derek Gilroy, Ewan Forrest, Alastair O’brien
Journal: Journal of Hepatology (2020)
Gynecologic radiology
Authors: W. Z. Stern
Journal: JAMA (1977)

THE PLAIN roentgenogram is the first step in the radiological evaluation of a gynecologic disorder. The bladder should be empty. Displacement of intestinal gas may be the clue to the presence of a pelvic mass. Except for vascular calcification, uterine leiomyoma constitutes the most common cause of pathological pelvic calcification. Subserosal and intramural myomas calcify more frequently than the submucosal variety. The calcification is typically flocculent, patchy, and coalescent (Fig 1), varying in size from tiny punctate deposits to large calcific masses. Occasionally, a uterine myoma may present with arcuate calcification, which must then be differentiated from a cystic lesion or an aneurysm. The plain roentgenogram is often helpful in detecting dermoid cysts of the ovary. About one third of such cysts contain dentigerous elements, thereby permitting a definitive diagnosis. Bone may be identified in about a fourth of the cases, frequently in association with teeth.<sup>1</sup>A circumscribed radiolucent image,
Charter on Medical Professionalism: Putting the Charter into Practice
Authors: Neil J. Smelser
Journal: Annals of Internal Medicine (2003)

Letters20 May 2003Charter on Medical Professionalism: Putting the Charter into PracticeNeil J. Smelser, PhDNeil J. Smelser, PhDUniversity of California, Berkeley; Berkeley, CA 94704 (Smelser)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-10-200305200-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Two comments are in order in response to the very apt observations on business practices brought forward by Dr. Haskell. First, in our development of the physician charter, we operated on the general conviction that a spare constitution of basic principles is preferable to one that is detailed and exhaustive. If the charter as an enunciation of principles were to be expanded, it would certainly include honesty, integrity, and efficiency in the business practices of physicians and medical organizations. Second, given our consistent stress on social and moral commitments and responsibilities, we would have highlighted the virtues of ... Author, Article, and Disclosure InformationAffiliations: University of California, Berkeley; Berkeley, CA 94704 (Smelser) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMedical Professionalism in the New Millennium: A Physician CharterCharter on Medical Professionalism: Putting the Charter into Practice Donatella Lippi , GianFranco Gensini , and Andrea A. Conti Charter on Medical Professionalism: Putting the Charter into Practice Neil J. Smelser Charter on Medical Professionalism: Putting the Charter into Practice Jerome C. Arnett Jr. Charter on Medical Professionalism: Putting the Charter into Practice Sylvia L. Cruess and Richard L. Cruess Charter on Medical Professionalism: Putting the Charter into Practice Robert Feldman Charter on Medical Professionalism: Putting the Charter into Practice Walter J. McDonald Charter on Medical Professionalism: Putting the Charter into Practice Steven A. Wartman Charter on Medical Professionalism: Putting the Charter into Practice Jordan J. Cohen Charter on Medical Professionalism: Putting the Charter into Practice Yevgeniya Nusinovich Charter on Medical Professionalism: Putting the Charter into Practice Risa Lavizzo-Mourey Charter on Medical Professionalism: Putting the Charter into Practice Christopher J. Lyons Charter on Medical Professionalism: Putting the Charter into Practice Richard L. Cruess and Sylvia L. Cruess Charter on Medical Professionalism: Putting the Charter into Practice Sadeq A. Quraishi and Ayesha N. Khalid Charter on Medical Professionalism: Putting the Charter into Practice Neil J. Smelser Charter on Medical Professionalism: Putting the Charter into Practice Charles M. Haskell Metrics 20 May 2003Volume 138, Issue 10Page: 852 ePublished: 20 May 2003 Issue Published: 20 May 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Thoracic Imaging—Annual Postgraduate Course
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Thoracic Imaging—Annual Postgraduate Course Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 5, November 1984, Page 1244, https://doi.org/10.1093/jnci/73.5.1244 Published: 01 November 1984
Abstract 1798: B-type Natriuretic Peptide and the Effect of Ranolazine in Patients with Non-ST Elevation Acute Coronary Syndromes in the MERLIN-TIMI 36 Trial
Authors: David A Morrow, Benjamin M Scirica, Marc S Sabatine, James A de Lemos, Sabina A Murphy, Petr Jarolim, Pierre Theroux, Christophe Bode, Eugene Braunwald
Journal: Circulation (2007)

Ranolazine is believed to exert anti-ischemic effects by reducing myocardial cellular Na + &amp; Ca 2+ overload and consequently LV wall stress. B-type natriuretic peptide (BNP) rises in response to increased wall stress and is a potent indicator of risk in ACS. Thus, we designed a prospective evaluation of the interaction between BNP and the effect of ranolazine as part of a randomized, blinded, placebo-controlled trial. METHODS : We measured plasma BNP (ADVIA BNP) at baseline (N = 4543) in pts with non-ST elevation ACS randomized to ranolazine or placebo in the MERLIN-TIMI 36 trial. Pts were stratified using BNP &gt;80 pg/ml based on prior work. The 1 o endpoint was a composite of cardiovascular death, myocardial infarction, or recurrent ischemia (CVD/MI/RI). RESULTS : Pts with an elevated BNP (N = 1935) were at significantly higher risk of CVD/MI/RI (26.4% vs. 20.4%, p &lt; 0.0001), CVD/MI (16.2% vs. 7.5%, p&lt;0.0001) and CVD alone (9.0% vs. 2.4%, p&lt;0.0001). In pts with BNP&gt;80 pg/ml, ranolazine reduced the primary endpoint (HR 0.79; 95%CI 0.66 – 0.94, p=0.009) contrasting with the lack of detectable effect in those with a negative BNP result ( Figure , p-interaction = 0.05). The apparent effect of ranolazine in pts with BNP&gt;80 pg/ml was directionally similar when considering both recurrent ischemia (HR 0.78; 0.62–0.98; p = 0.04) and CVD/MI (HR 0.83; 0.66–1.05, p= 0.12, p-interaction 0.07). CONCLUSIONS : Elevated BNP is associated with worse outcomes in ACS. The results of this planned exploratory analysis suggest that ranolazine may have enhanced efficacy in pts with elevated BNP. The potential interaction of biomarkers of hemodynamic stress and the effects of ranolazine warrants additional study.
Identification of MicroRNA Expression Patterns and Definition of a MicroRNAs/mRNA Regulatory Network in Distinct Molecular Groups of Multiple Myeloma.
Authors: Marta Lionetti, Marta Biasiolo, Luca Agnelli, Katia Todoerti, Laura Mosca, Sonia Fabris, Gabriele Sales, Giorgio Lambertenghi Deliliers, Silvio Bicciato, Luigia Lombardi, Stefania Bortoluzzi, Antonino Neri
Journal: Blood (2009)
A Versatile and Scalable Two-Step Ion-Exchange Chromatography Process for the Purification of Recombinant Adeno-associated Virus Serotypes-2 and -5
Authors: N BRUMENT, R MORENWEISER, V BLOUIN, E TOUBLANC, I RAIMBAUD, Y CHEREL, S FOLLIOT, F GADEN, P BOULANGER, G KRONERLUX
Journal: Molecular Therapy (2002)

Here we describe the development of a two-step chromatography process based on the use of ion-exchange resins for the purification of recombinant adeno-associated virus (rAAV) serotypes-2 and -5. In vitro and in vivo results demonstrate that this method, which does not require any prepurification step of the cell lysate, can be applied to obtain highly pure rAAV2 and rAAV5 stocks. As such, this procedure can be easily transferred in vector cores and also scaled up, allowing the direct comparison of these two, and potentially other, AAV serotypes in large animal models.
Experimentelle Studier over den overførbare hønseleukose (mit deutscher Zusammenfassung)
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amino acid transport and glutathione homeostasis: What is the mechanism for cysteine uptake from bile?
Authors: M Mailliard
Journal: Hepatology (1993)

Transport of L-cysteine and a cysteine S-conjugate, S-(1,2-dichlorovinyl)-L-cysteine (DCVC) was investigated in rat liver canalicular plasma membrane (cLPM) vesicles. Cysteine uptake into an osmotically active intravesicular space was temperature sensitive and further enhanced by an inwardly directed Na+ gradient. Na+ -dependent and -independent L-cysteine uptake exhibited saturation kinetics with apparent Km of 53 ± 0.7 and 1300 ± 300 μM and Vmax of 95 ± 21 and 1600 ± 200 pmol ± mg protein−1; 10 sec−1 for the Na+ dependent components, and an apparent Km of 207 ± 48 μM and a Vmax of 355 ± 71 pmol ± mg protein−1 ± 10 sec−1 for the Na+ -independent component. Na+-dependent uptake was inhibited by L-alanine, glycine, L-phenylalanine and L-leucine, whereas Na+-independent uptake was inhibited by L-phenylalanine, L-leucine and 2-amino-2-norbornanecarboxylic acid. Both Na+ -dependent and -independent L-cysteine transport processes were inhibited by several cysteine S-conjugates, with DCVC having the strongest effect. Inhibition of [35S]-cysteine uptake by DCVC was noncompetitive with a K, of 1.2 ± 0.1 mM. On the other hand, uptake of [35 S IDCVC by the rat cLPM vesicles was not stimulated by a Na+-gradient, but was inhibited by several other amino acids, including L-cysteine. Further investigation of [35SlDCVC uptake in rat cLPM vesicles indicated a saturable Na+ -independent process with an apparent K, of 155 f 42 μM, and a Vmax of 393 f 53 pmol mg protein −1 5 sec −1. Time-dependent nonspecific binding of DCVC to rat cLPM vesicles was diminished by addition of aminooxyacetic acid, an inhibitor of cysteine conjugate β-lyase activity. These findings demonstrate that cysteine and DCVC uptake into cLPM vesicles occurs by both saturable and nonsaturable transport mechanisms. These transport pathways may function in vivo for uptake and recycling of biliary L-cysteine for glutathione turnover and some cysteine S-conjugates for intrahepatic mercapturic acid biosynthesis.
Hamstringing the Army
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Le neurosi del cuore e dei vasi sanguigni e loro cura.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alergia nasal: Coriza o rinitis espasmódica: Sintomatología, diagnóstico, reacciones alérgicas concomitantes, tratamiento. Anafilaxia y alergia: Conceptos modernos
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal