tbuckley/cabot-search huggingface dataset:
Questions and Answers
Journal: JAMA (1982)

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No Improvement of Posttraumatic Stress Disorder Symptoms With Guanfacine Treatment
Authors: Thomas C. Neylan, Maryann Lenoci, Kristin W. Samuelson, Thomas J. Metzler, Clare Henn-Haase, Robert W. Hierholzer, Steven E. Lindley, Christian Otte, Frank B. Schoenfeld, Jerome A. Yesavage, Charles R. Marmar
Journal: American Journal of Psychiatry (2006)

Objective: The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD). Method: Veterans with chronic PTSD who were medication-free or receiving stable pharmacotherapy were randomly assigned to guanfacine (N=29) versus placebo (N=34). Results: Guanfacine had no effect on PTSD symptoms, subjective sleep quality, or general mood disturbances. Guanfacine was associated with a number of side effects. Conclusions: These results do not support the use of alpha 2 agonists in veterans with chronic PTSD.
Fungi as a Cause of Otitis
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enfance et hérédité. Par A
Journal: JAMA (1934)

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Diseases of the Bladder and Prostate
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
288. Dual-Regulated Lentiviral Vector for Gene Therapy of X-Linked Chronic Granulomatous Disease
Authors: Giada Farinelli, Maria Chiriaco, Valentina Capo, Erika Zonari, Maddalena Migliavacca, Raisa Jofra Hernandez, Samantha Scaramuzza, Gigliola Di Matteo, Lucia Sergi Sergi, Alice Rossi, Serena Ranucci, Alessandra Bragonzi, Anna Kajaste-Rudnitski, Didier Trono, Manuel Grez, Paolo Rossi, Andrea Finocchi, Luigi Naldini, Bernhard Gentner, Alessandro Aiuti
Journal: Molecular Therapy (2015)

Chronic Granulomatous Disease (CGD) is caused by defective NADPH oxidase function in phagocytes leading to increased susceptibility to fungal and bacterial infections. The majority of CGD is caused by mutations in the gp91phox gene. Gene therapy with hematopoietic stem cells (HSC) may represents a good alternative to allogenic haematopoietic stem cell transplantation. Past clinical trials for X-linked CGD with γ retroviral vectors resulted in transient clinical benefit but were limited by insertional oncogenesis and lack of persistent engraftment. To circumvent these issues we developed a strategy based on regulated, self-inactivating lentiviral vectors (LVs). We designed different gp91phox-expressing LVs: 1) PGK.gp91phox, in which gp91phox is driven by an ubiquitous cellular promoter; 2) MSP.gp91phox, to control the transgene expression at a transcriptional level using a myeloid specific promoter; 3) PGK.gp91phox_126T(2), in which we exploited the miRNA system, incorporating miR-126 target sequences, to prevent the transgene off-target expression in HSC; 4) MSP.gp91phox_126T(2), combining the posttranscriptional de-targeting with the MSP (dual regulated vector). These LVs were tested on human and murine HSC and in a mouse model of X-CGD. All vectors restored gp91phox expression and function in human X-CGD primary monocytes and differentiated myeloid cells. While unregulated LVs induced a transgene ectopic expression in CD34+ cells, transcriptionally and post-transcriptionally regulated LVs reduced this off-target expression while guaranteeing a good level of expression in differentiated cells. With the dual-regulated vector, we achieved high levels of myeloid-specific transgene expression, entirely sparing the most primitive CD34+CD38-CD90+ HSC compartment. X-CGD mice transplanted with all vectors engrafted and restored gp91phox expression, with 20-70% of granulocytes and monocytes expressing human gp91phox, persisting up to 10 months after gene therapy. MSP-driven vectors were superior in maintaining regulation during BM development. Oxidase activity in corrected granulocytes was superior using MSP-driven vectors as compared to PGK. Gene therapy-treated mice were then infected with S.aureus in order to test their ability to clear one of the most recurrent bacteria causing infections in CGD patients. All gene therapy treated mice were able to clear pulmonary infection in contrast with untreated X-CGD untreated mice. The dual-regulated LV represents a promising approach for further clinical development of gp91phox therapeutic vectors.
Esophageal echocardiography.
Authors: L Frazin, J V Talano, L Stephanides, H S Loeb, L Kopel, R M Gunnar
Journal: Circulation (1976)

Esophageal echocardiography has been developed for use in patients with chronic obstructive pulmonary disease and is a safe diagnostic procedure which provides high resolution mirror image echoes of many cardiac structures. Conventional anterior and esophageal echocardiograms were performed in 38 subjects. Esophageal echoes were of diagnostic quality in all 38 subjects, anterior echoes were of diagnostic quality in only 18. Measurements from anterior and esophageal echocardiograms correlated well for aortic valve diameter (r = 0.87), left atrium diameter (r = 0.96), mitral valve EF slope (r = 0.97) and less well for aortic root diameter (r = 0.69).
Acute Disseminated Penicilliosis: Report of a Case and Review of Literature
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fetal risk associated with rubella vaccine
Authors: S. R. Preblud
Journal: JAMA (1981)

Ninety-four susceptible women received either Cendehill or HPV-77 rubella vaccine. All gave birth to healthy infants. Seventeen susceptible women received the RA 27/3 vaccine. All their infants were free of abnormalities compatible with congenital rubella, as were 54 born to mothers of unknown immune status at the time of RA 27/3 vaccination and those later found to be immune. An additional susceptible woman received an unknown strain of vaccine; she also had a healthy infant. The risk of severe congenital malformations after rubella vaccination is low. In our 112 cases, the maximum risk was approximately 3%. Concern about the potential adverse effects of rubella vaccine on the fetus should not interfere with vaccination of women of childbearing age. However, since the actual risk may not be zero, women known to be pregnant should not be vaccinated, and conception should be avoided for three months after vaccination. (<i>JAMA</i>1981;246:1413-1417)
Dunglison's New Pronouncing Medical Dictionary.
Journal: JAMA (1893)

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Disinfection of Hands and Instruments
Authors: C. B. Lockwood
Journal: BMJ (1897)

<b>Background and aim:</b> Hepatic Encephalopathy (HE) is a complication of cirrhosis and may lead to overt neurological signs. Sleep disorders are frequent in HE and alter the quality of life. Rifaximin is accepted as the treatment of overt HE. This study aimed to assess the effect of rifaximin on sleep disorders in overt HE. <b>Methods:</b> This was a pilot, crossover study involving all patients suffering from cirrhosis and overt HE admitted in our Liver Unit (June 2014- January 2015). The West Haven criteria assessed the HE severity (WH score). Patients underwent a 24-h polysomnography (PSG), and a 7-days actigraphy. They fulfilled questionnaires: Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety Depression scale (HAD). At the end of a one-month course of rifaximin, the same assessment was repeated. <b>Results:</b> Ten patients were included: six males, mean age 57±12 y. Child scores range from B7 to C15. Before rifaximin, WH score was 2.5±0.5, and PSG revealed a long sleep time on 24 h (698±240 min). Sleep quality was deteriorated with few stage 3 sleep (6% (0-39)) and REM sleep (6% (3-23)). Actimetry confirmed prolonged mean sleep time/24h (556 min (183-808)). Questionnaires showed an impaired sleep quality (mean score of 11±4 on PSQI), and symptoms of anxiety and depression (HAD A 10+5, HAD D 12+6). After rifaximin, the WH score decreased: 1.7±0.5. Sleep quality was improved on PSG: stage 3 sleep increased to 32% (6-56), p=0.04, and REM sleep to 11% (0-27), p=0.04. Sleep time/24h decreased to 290 (53-701) min, p=0.03 on actigraphy. No changes were observed on questionnaires. <b>Conclusion:</b> Rifaximin as a treatment of overt HE is associated with decreased sleep time/24h and significant improvement in sleep quality.
Hand grenade injuries among civilians
Authors: R. M. Coupland
Journal: JAMA (1993)

<h3>Objectives.</h3> —To describe how noncombatants are injured by hand grenades in camps for displaced people, and to categorize grenade wounds according to the Red Cross wound classification. <h3>Design.</h3> —Case series. <h3>Setting.</h3> —A surgical hospital in Khao I Dang refugee camp on the ThailandCambodia border. <h3>Patients.</h3> —Seventy-four patients injured by hand grenades. <h3>Interventions.</h3> —Intravenous antibiotics and primary wound surgery. <h3>Main Outcome Measures.</h3> —Combatant status of the patients, categorization of the wounds, surgical outcome, number of operations, and number of blood transfusions. <h3>Results.</h3> —Only 7% of the patients sustained their wounds in battle and 50% were women, children, or older men. Seventy had 91 wounds that could be categorized; 59% of the wounds were small, affecting only soft tissue. Few wounds were associated with fractures and none with comminuted fractures. Twenty-four soft-tissue wounds were treated conservatively with minimal morbidity and no mortality. <h3>Conclusions.</h3> —Missiles (fragments or bullets) from hand grenades tend to produce wounds with little tissue damage. Serious injury is due to penetration of vital structures. The results permit a recommendation that certain small and uncomplicated fragment wounds can be treated initially without surgery. (<i>JAMA</i>. 1993;270:624-626)
MEDICAL SOCIETIES.
Journal: JAMA (1900)

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SLIPPING RIB
Authors: R. Davies-Colley
Journal: BMJ (1922)

MTDICALJOI_~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~EIA alkalis.The lipoids contained by bacteria, because of their effect on surface tension, are probably concentrated rouind the periphery of the bacterial cells, and form a protective covering to the organism.This fatty envelope protects tlhenm from proteolytic ferments, but once tllis lhas been removed active proteolysis tales place.Higl ternperatures and dryincg cause a redistribution of tlle lipoid-protein complex, aud tlius, for physical reasons, disturb tlle protective mechanism.rTherefore the antitryptic property of bacteiia depends on totally different factors fromn the antitrypsin of egg wlhite and blood serum.Teale and Bach7 showed that the antitryptic power of egg white wos due to the preseince of a non-diffusible protein substanice whicl is not affected in the dry state by treatmenit witih lipoid solvents.Th''e same observers showe-d that the antitrypsin of blood serum was not dependelnt on the li-poids preselnt.,Although lipoid solvents appear to destroy the antitrypsin of blood serum, they do tllis by coagulating tlle proteins.Drying lhad no effect on tlle antitrypsin of blood seruim, nor was it destroyed by lipoid solvents wlenl precautions were taken to prevent protein coagulation.Tlhe greater resistance of Gram-positive bacilli to lipoid solvents,and Iieat is also capable of explarnation on the basis of the phlysical dispersion of tlle lipoids.E isenberg8 found that staphylococci became Gram-niegative after extraction with ether and that B. coli could be made Gram-positive on treatment with lecithin.Benians9 observed that crushed Gram-positive,organisms are promptly decolorized, and conieluded that the con(lition of the cell wall is the factor determining resistance to Gram's stain.
Atlas of Female Pelvic Anatomy.
Authors: None E. W. A.
Journal: JAMA (1885)

This is a new and important contribution to anatomical science. The author is quite well and favorably known on both sides of the Atlantic, from his former works, "Manual of Gynæcology " (with Dr. Barbour) and " Structural Anatomy of Female Pelvic Floor." The present work is as masterly and complete as seems possible on such a subject. Most of the delineations are new and valuable, especially those forming the plates on fœtal developments and the frozen sections. Imperfections in our knowledge of precise regional anatomy, especially in the diseases of women, have been the cause of confusion of ideas and disputed theories, with much fruitless discussion. The present work will in future furnish a basis for greater accuracy and precision to all gynæcologists who will avail themselves of it. It is a handsome quarto volume containing about forty colored plates, all drawn from actual dissections with extreme care and fidelity. As
From the Centers for Disease Control. Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome
Journal: JAMA (1990)

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Stavudine Approved for Certain Patients With Advanced HIV
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal