tbuckley/cabot-search huggingface dataset:
Aspirin increases the bleeding side effects in essential thrombocythemia independent of the cyclooxygenase pathway: Role of the lipoxygenase pathway
Authors: Sergio Cortelazzo, Marina Marchetti, Elisabetta Orlando, Anna Falanga, Tiziano Barbui, Michael R. Buchanan
Journal: American Journal of Hematology (1998)

Acetylsalicylic acid (ASA) is currently recommended as an antithrombotic for patients with essential thrombocythemia (ET) who are at an increased risk of thrombotic events.However, ASA is also associated with an increased risk of bleeding in these patients as compared to the risk of bleeding in other patients treated with ASA.Recent data suggest that while ASA inhibits platelet thromboxane A 2 (TxA 2 ) synthesis in all individuals, ASA has little effect or inhibits the lipoxygenase pathway (i.e., 12-hydroxyeicosatetranoic acid or 12-HETE synthesis) in some individuals, and enhances 12-HETE synthesis in others.These differential effects are associated with a pronounced prolongation of the bleeding time vs. no prolongation of the bleeding time, respectively, i.e., in ASA responders and ASA nonresponders, respectively.To determine if the increased risk of ASA-induced bleeding seen in ET patients is associated with an effect on 12-HETE synthesis, we compared the relative effects of ASA on the bleeding time, platelet TxA 2 and 12-HETE synthesis, and platelet aggregation and adhesion in ET patients and healthy volunteers.ASA (300 mg, taken orally) prolonged the bleeding time in 82% of the ET patients but only 27% of the healthy volunteers although platelet TxA 2 synthesis and ADP-and collagen-induced aggregation were inhibited significantly in both groups.In contrast, platelet 12-HETE synthesis was unchanged and platelet adhesion was decreased in those patients and volunteers whose bleeding times were prolonged by ASA, whereas platelet 12-HETE synthesis was increased significantly and platelet adhesion was unaffected in those patients and volunteers whose bleeding times were not prolonged, and in some cases shortened by ASA.These results confirm previous data that demonstrate that ASA has different effects on platelet 12-HETE synthesis and platelet adhesion in different individuals, i.e., inhibitory or no effect in ASA responders (in whom ASA prolonged bleeding) vs. enhancing effects in ASA nonresponders (in whom ASA did not prolong bleeding).These results also indicate that there is a greater percentage of ASA responders in patients with ET than that seen in the general population, a difference that is associated with an effect of ASA on the lipoxygenase pathway.This may explain the increased bleeding side effects seen in the ET patient population.Am.
Diätetik der Magen- und Darmkrankheiten.
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentaries on the end of year editorial on the definition of ischaemia in last December's issue
Authors: B. Vanheel, A De Hemptinne
Journal: Cardiovascular Research (1995)

Journal Article Commentaries on the end of year editorial on the definition of ischaemia in last December's issue Get access Bert Vanheel, Professor, Bert Vanheel, Professor Department of Physiology and Physiopathology, University of Gent, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar A De Hemptinne, Professor A De Hemptinne, Professor Department of Physiology and Physiopathology, University of Gent, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 2, February 1995, Pages 286–287, https://doi.org/10.1016/S0008-6363(95)90008-X Published: 01 February 1995
MISSISSIPPI VALLEY MEDICAL ASSOCIATION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AUTHORS' REPLY
Authors: N C Barnes, C D Sheldon
Journal: Thorax (1993)

Notification of tuberculosis: how many cases are never reported?Tower Hamlets is not the only London borough to report significant recent under- notification of tuberculosis (27%) (December 1992;47:1015-8).Hickman et alt reported 26% undernotification of non-HIV associated tuberculosis and 60% undemoti- fication of HIV related tuberculosis for the Riverside DHA for the period April 1990 to March 1991.Riverside have tightened procedures to reduce or prevent undemotification and hopefully Tower Hamlets have done so too.Correction of undernotifica- tion from these districts, and possibly others, may be contributing to the recent rise in tuberculosis notifications in England and Wales, particularly since 1989.The use of pathology and microbiology services to supplement notification has been reported.2An integrated and centralised tuberculosis service for a district would overcome many of these problems, but it is easier to implement in a DHA or Trust without multiple units.In the Blackburn, Hyndburn and Ribble Valley DHA, served by two acute hospitals of 400 and 550 beds, there is no undernotification because of our integrated system which has three key compo-
GLANDERS
Authors: RALPH W.  MENDELSON
Journal: Annals of Internal Medicine (1936)

Article1 July 1936GLANDERSRALPH W. MENDELSON, M.D., F.A.C.S., F.A.C.P.RALPH W. MENDELSON, M.D., F.A.C.S., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-1-43 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGlanders, although an uncommon disease in man, is so frequently misdiagnosed, so pernicious in its manifestations and of such great importance as a public health problem when it does occur that it merits more attention than it has so far received. There are but few states that provide, in their public health laws, for the protection of their residents against this disease. Since the advent of the motor car, glanders in man has materially decreased, but in rural districts and especially in the southwestern states many cases probably go undiagnosed and constitute a genuine danger to the public health.Strictly... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Albuquerque, New Mexico*Received for publication June 1, 1935.†Actinobacillus mallei. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCo-existent chronic glanders and multiple cystic osseous tuberculosis treated with streptomycin 1 July 1936Volume 10, Issue 1Page: 43-48KeywordsPrevention, policy, and public health ePublished: 1 December 2008 Issue Published: 1 July 1936 PDF downloadLoading ...
RAG1, RAG2 and TdT expression in adult human liver: Evidence of extrathymic T cell differentiation ERC1, Liver Unit2 &amp; Dept. of Surgery3, St. Vincent's Hospital, Elm Park, Dublin 4, Ireland
Journal: Hepatology (1995)

Severe combined immunodeficiency can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as recombination-activating gene 1 (RAG1), RAG2, or DNA cross-link repair 1C (DCLRE1C). Defective DNA recombination causes a developmental block in T and B cells, resulting in high susceptibility to infections. Hypomorphic mutations in the same genes can also give rise to a partial loss of T cells in a spectrum including leaky severe combined immunodeficiency (LS) and Omenn syndrome (OS). These patients not only experience life-threatening infections because of immunodeficiency but also experience inflammatory/autoimmune conditions caused by the presence of autoreactive T cells.We sought to develop a preclinical model that fully recapitulates the symptoms of patients with LS/OS, including a model for testing therapeutic intervention.We generated a novel mutant mouse (Dclre1cleaky) that develops a LS phenotype. Mice were monitored for diseases, and immune phenotype and immune function were evaluated by using flow cytometry, ELISA, and histology.Dclre1cleaky mice present with a complete blockade of B-cell differentiation, with a leaky block in T-cell differentiation resulting in an oligoclonal T-cell receptor repertoire and enhanced cytokine secretion. Dclre1cleaky mice also had inflammatory symptoms, including wasting, dermatitis, colitis, hypereosinophilia, and high IgE levels. Development of a preclinical murine model for LS allowed testing of potential treatment, with administration of cytotoxic T-lymphocyte-associated protein 4-Ig reducing disease symptoms and immunologic disturbance, resulting in increased survival.These data suggest that cytotoxic T-lymphocyte-associated protein 4-Ig should be evaluated as a potential treatment of inflammatory symptoms in patients with LS and those with OS.
Intravenous Pyelogram in Hypertensive Patients
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UPDATE ON THE EFFICACY AND AVAILABILITY OF LEVAMISOLE AND 5-FLUORURACIL
Journal: JNCI Journal of the National Cancer Institute (1989)

UPDATE ON THE EFFICACY AND AVAILABILITY OF LEVAMISOLE AND 5-FLUORURACIL Get access JNCI: Journal of the National Cancer Institute, Volume 81, Issue 24, 20 December 1989, Page 1938, https://doi.org/10.1093/jnci/81.24.1938 Published: 20 December 1989
Survival Outcomes In Relapsed/Refractory Acute Myeloid Leukemia Patients Who Achieve Less-Than-Complete Response After Salvage Therapy
Authors: Shilpan S. Shah, Hagop M Kantarjian, Farhad Ravandi, Susan O'Brien, Guillermo Garcia-Manero, Michael Andreeff, Marina Konopleva, Elias Jabbour, Sherry R. Pierce, Gautam Borthakur, Jorge E. Cortes
Journal: Blood (2013)
ASSESSMENT OF BONE MASS AT DIFFERING SKELETAL SITES BY MULTIPLE DIAGNOSTIC PARAMETERS.
Authors: Charles H. Chesnut, James A. Hanson, Raymond F. Kilcoyne, Robert Murano, Thomas K. Lewellen, Wil B. Nelp, Lawrence Mack, Michael M. Graham
Journal: Clinical Nuclear Medicine (1983)

Chesnut, Charles H.; Hanson, James A.; Kilcoyne, Raymond F.; Murano, Robert; Lewellen, Thomas K.; Nelp, Wil B.; Mack, Lawrence; Graham, Michael M. Author Information
Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
Authors: Cecile A.W. Geuijen, Camilla De Nardis, David Maussang, Eric Rovers, Tristan Gallenne, Linda J.A. Hendriks, Therese Visser, Roy Nijhuis, Ton Logtenberg, John de Kruif, Piet Gros, Mark Throsby
Journal: Cancer Cell (2021)
The Biology of Tissue Transplantation
Authors: Paul S. Russell, Anthony P. Monaco
Journal: New England Journal of Medicine (1964)

Clinical and Organ TransplantationExperimental Organ TransplantationMuch experimental work has been done in the technical realm of organ transplantation. Although some of these efforts antedated Carrel and Guthrie, their ingenious exploratory work,537 early in this century, ushered in the present era. Their work included the grafting of the entire head of a puppy to the cervical vessels of a larger recipient dog, the reimplantation of canine extremities and the transplantation of kidneys.In recent years further advances have been made as special attention has been paid to the technical problems surrounding transplantation of a wide variety of organs and . . .
TRACHOMA IN THE UNITED STATES.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Catheter Guiding Forceps for Use in Bronchography
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brominated Flame Retardants: A Novel Class of Developmental Neurotoxicants in Our Environment?
Authors: Per Eriksson, Eva Jakobsson, Anders Fredriksson
Journal: Environmental Health Perspectives (2001)

Brominated flame retardants are a novel group of global environmental contaminants. Within this group the polybrominated diphenyl ethers (PBDE) constitute one class of many that are found in electrical appliances, building materials, and textiles. PBDEs are persistent compounds that appear to have an environmental dispersion similar to that of polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT). Levels of PBDEs are increasing in mother's milk while other organohalogens have decreased in concentration. We studied for developmental neurotoxic effects two polybrominated diphenyl ethers, 2,2',4,4'-tetrabromodiphenyl ether (PBDE 47) and 2,2',4,4',5-pentabromodiphenyl ether (PBDE 99)--congeners that dominate in environmental and human samples--together with another frequently used brominated flame retardant, tetrabromo-bis-phenol-A (TBBPA). The compounds were given to 10-day-old NMRI male mice, as follows: PBDE 47, 0.7 mg (1.4 micromol), 10.5 mg (21.1 micromol)/kg body weight (bw); PBDE 99, 0.8 mg (1.4 micromol), 12.0 mg (21.1 micromol)/kg bw; TBBPA, 0.75 mg (1.4 micromol), 11.5 mg (21.1 micromol)/kg bw. Mice serving as controls received 10 mL/kg bw of the 20% fat emulsion vehicle in the same manner. The present study has shown that neonatal exposure to PBDE 99 and PBDE 47 can cause permanent aberrations in spontaneous behavior, evident in 2- and 4-month-old animals. This effect together with the habituation capability was more pronounced with increasing age, and the changes were dose-response related. Furthermore, neonatal exposure to PBDE 99 also affected learning and memory functions in adult animals. These are developmental defects that have been detected previously in connection with PCBs.
Abstract 876: Combined Inhibition Of Ccl2, Cx3cr1 And Ccr5 Abrogates Ly6chi And Ly6clo Monocytosis And Almost Abolishes Atherosclerosis In Hypercholesterolemic Mice
Authors: Stephane Potteaux, Christophe Combadiere, Adeline Pezard, Stephanie Riou, Tabassome Simon, Mathieu Rodero, Bruno Esposito, Regine Merval, Amanda Proudfoot, Stephanie Lehoux, Alain Tedgui, Ziad Mallat
Journal: Circulation (2007)

Monocytes are critical mediators of atherogenesis. Specialized chemokine/chemokine receptor pathways orchestrate the infiltration of specific monocyte subsets within atherosclerotic arteries. Interruption of individual chemokine pathways including CCL2/CCR2, CCL5/CCR5, CX3CL1/CX3CR1, CXCL8/CXCR2 or CXCL10/CXCR3, leads to significant but only partial inhibition of lesion development, whereas deficiency in other signals such as CXCL16 or CCR1 accelerates atherosclerosis. Evidence that particular chemokine pathways may cooperate to promote monocyte recruitment into atherosclerotic arteries is still lacking. Here, we show that in addition to the current prevailing paradigm accounting for the role of chemokines as modulators of monocyte trafficking between the blood and the vessel wall, chemokine-mediated signals critically determine the frequency of monocytes in the blood and the bone marrow under both non-inflammatory and atherosclerotic conditions. Particularly, CCL2, CX3CR1 and CCR5-dependent signals differentially alter CD11b+ Ly6G- 7/4hi (also known as Ly6Chi) and CD11b + Ly6G- 7/4lo (Ly6Clo) monocytosis. Combined inhibition of these pathways in hypercholesterolemic, atherosclerosis susceptible apolipoprotein E-deficient mice leads to additive reduction in bone marrow and circulating monocytes, associated with a marked and additive 90% reduction in atherosclerosis. Lesion size highly correlates with the number of circulating monocytes. Thus, signals mediated through CCL2, CX3CR1 and CCR5 critically determine the frequency of circulating monocyte subsets and thereby account for almost all macrophage accumulation into atherosclerotic arteries.
Daring Experiment of a Physician on Himself with Typhoid Bacilli
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DEATHS OF PHYSICIANS IN 1921
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal