tbuckley/cabot-search huggingface dataset:
Human values and curriculum design. A view for the future
Authors: E. F. Rosinski
Journal: JAMA (1969)

I would like to do three things—make some observations as to what has been said; reflect on what is our present status; and, as the charge has been given us, see if it is possible to chart a course for the future. To those not directly involved in medical education or the practice of medicine, it might seem unusual, if not somewhat disarming, that the profession is devoting time and attention to the subject, "human values." Unusual and disarming, for traditionally human values have been considered synonymous with medicine. To the layman it is inconceivable that anyone could practice medicine without a deep commitment to human values, for from his initiation to the profession to the time of his death, the physician is instilled with a profound respect for human values. The initiation takes place in medical schools which pride themselves on their educational objectives. These usually begin with a
PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk
Authors: Smrita Sinha, Ya-Yuan Fu, Adrien Grimont, Maren Ketcham, Kelly Lafaro, Joseph A. Saglimbeni, Gokce Askan, Jennifer M. Bailey, Jerry P. Melchor, Yi Zhong, Min Geol Joo, Olivera Grbovic-Huezo, In-Hong Yang, Olca Basturk, Lindsey Baker, Young Park, Robert C. Kurtz, David Tuveson, Steven D. Leach, Pankaj J. Pasricha
Journal: Cancer Research (2017)

Abstract Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progression of pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation in the microenvironment of precancerous pancreatic lesions, known as pancreatic intraepithelial neoplasms (PanIN), and describe a unique subpopulation of neuroendocrine PanIN cells that express the neuropeptide substance P (SP) receptor neurokinin 1-R (NK1-R). Using organoid culture, we demonstrated that sensory neurons promoted the proliferation of PanIN organoids via SP-NK1-R signaling and STAT3 activation. Nerve-responsive neuroendocrine cells exerted trophic influences and potentiated global PanIN organoid growth. Sensory denervation of a genetically engineered mouse model of PDAC led to loss of STAT3 activation, a decrease in the neoplastic neuroendocrine cell population, and impaired PanIN progression to tumor. Overall, our data provide evidence that nerves of the PanIN microenvironment promote oncogenesis, likely via direct signaling to neoplastic neuroendocrine cells capable of trophic influences. These findings identify neuroepithelial cross-talk as a potential novel target in PDAC treatment. Cancer Res; 77(8); 1868–79. ©2017 AACR.
Correction: Changes in Intake of Fruits and Vegetables and Weight Change in United States Men and Women Followed for Up to 24 Years: Analysis from Three Prospective Cohort Studies
Authors: Monica L. Bertoia, Kenneth J. Mukamal, Leah E. Cahill, Tao Hou, David S. Ludwig, Dariush Mozaffarian, Walter C. Willett, Frank B. Hu, Eric B. Rimm
Journal: PLoS Medicine (2016)
Monovular Twins
Authors: G. H. Pickering
Journal: BMJ (1946)

Memory formation is crucial for the survival of animals. Here, we study the effect of different crh-1 (C. elegans homolog of mammalian CREB1) mutations on the ability of C. elegans to form long-term memory (LTM). Null mutants in creb1/crh-1 are defective in LTM formation across phyla. We show that specific isoforms of CREB1/CRH-1, CRH-1c and CRH-1e, are primarily responsible for memory related functions of the transcription factor in C. elegans. Silencing of CRH-1e expressing neurons during training for LTM formation abolishes the long-term memory of the animal. Further, CRH-1e expression in RIM or AVE neurons is sufficient to rescue long-term memory defects of creb1/crh-1 null mutants. We show that apart from being LTM defective, creb1/crh-1 null mutant animals show defects in native chemotaxis behavior. We go on to characterize the amino acids K247 and K266 as responsible for the LTM related functions of CREB1/CRH-1 while being dispensable for its native chemotaxis behavior. These findings provide insight into the spatial and temporal workings of a crucial transcription factor and can be further exploited to find CREB1 targets involved in the process of memory formation.
Tobacco Addiction
Authors: Andrea Lyman
Journal: JAMA (1996)

<h3>To the Editor.</h3> —In the Addiction Medicine section of the Contempo issue,<sup>1</sup>I was surprised to find no mention of what is surely major news in the drug dependence field: the recent availability of nonprescription nicotine replacement agents. Nicotine replacement has been found to be an important modality in treating dependence on nicotine,<sup>2</sup>the drug responsible for the overwhelming preponderance of mortality from drug use. Addiction specialists are increasingly recognizing the benefit of including nicotine addiction treatment in their work,<sup>3</sup>but this was not reflected in the article by Drs Wesson and Ling.
Anti-Stunning and Anti-Infarct Effects of Adenosine-Enhanced Ischemic Preconditioning
Authors: Yoshiya Toyoda, Vincenzo Di Gregorio, Robert A. Parker, Sidney Levitsky, James D. McCully
Journal: Circulation (2000)

Background —Adenosine-enhanced ischemic preconditioning (APC) extends the protection afforded by ischemic preconditioning (IPC) by both significantly decreasing infarct size and significantly enhancing post-ischemic functional recovery. In this study, the anti-infarct effects and the anti-stunning effects of APC in contributing to enhanced post-ischemic functional recovery were determined and compared with IPC. Methods and Results —Sheep (n=96) were subjected to 15, 30, 45, or 60 minutes of regional ischemia and 120 minutes of reperfusion. IPC hearts received 5 minutes of regional ischemia and 5 minutes of reperfusion before ischemia/reperfusion. APC hearts received a bolus injection of adenosine coincident with IPC. Adenosine hearts (ADO) received a bolus injection of adenosine before ischemia/reperfusion. Regional ischemia (RI) hearts received no pretreatment. Infarct size/area at risk was determined by tetrazolium staining. Regional myocardial function was determined by sonomicrometry. Segment shortening after 15 minutes of ischemia in which no infarct was incurred was 32.1±10.6% in RI, 70.6±8.5% in IPC, and 77.4±6.0% in APC hearts. Segment shortening after 30 minutes of ischemia was 60.7±6.3% in APC hearts ( P &lt;0.05 versus RI, ADO, IPC) but was &lt;37% in all other groups. Infarct size/area at risk after 30 and 60 minutes of ischemia was, respectively, 25.8±5.7% and 49.8±6.0% in RI, 12.9±3.0% and 29.2±5.0% in ADO, 11.6±2.4% and 24.6±2.7% in IPC, and 5.1±1.6% and 12.4±2.0% in APC hearts ( P &lt;0.05 versus RI, ADO, IPC). Conclusions —APC and IPC exhibit anti-infarct and anti-stunning effects in the ovine heart, but these effects are rapidly diminished with IPC. APC significantly extends these effects, providing for significantly enhanced infarct size reduction and post-ischemic functional recovery ( P &lt;0.05 versus IPC).
NEW VIEWS OF A TRADITIONAL DRUG
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Skybridge
Authors: Kevin P. Eaton
Journal: Journal of Clinical Oncology (2014)

The expanse of America collapses here in this medical center.When a surgeon opens a calcified artery, salt pours from dry bulk containers on Long Beach.When kids play basketball in Jackson Park, hearts beat again with every dribble.Each building is a different city.Skybridges take us all across America, coast to coast in just one afternoon. She wanted to go to San Francisco.A new grandmother, she told me.Her PET scan mapped the power grid along the East Coast, now dusk.A shortcut, I told her, to beat the setting sun.I hugged her at the door, and through falling tears, she melted like watercolor over the sun-painted skybridgethe one coursing through the Sierra Nevada as it crosses over Main Street.She'd be West before I could close her chart, before I would stop waving
INTERNIST
Authors: RANDOLPH A MILLER
Journal: Annals of Internal Medicine (1984)

Software1 April 1984INTERNISTRANDOLPH A MILLER, M.D.RANDOLPH A MILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-622 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDo not confuse internist™ with the INTERNIST-1 program (now part of Caduceus) developed and evaluated by Pople, Myers, and Miller (N Engl J Med. 1982; 307:468-76). The two programs have nothing in common. According to advertisements placed in computer magazines, INTERNIST™ can do differential diagnoses on any combination of over 450 symptoms for 331 chronic and acute diseases. A special reference module allows you to display (or printout) all symptoms usually associated with any of these diseases.The goal of the program is to analyze a set of findings specified by the user. The user selects the findings from a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySoftware Review of The INTERNIST™RANDOLPH A. MILLER, M.D.Critical Reviewing of SoftwareM.S. BLOIS, M.D.Authorship for SoftwareJAMES A. COWAN, M.D. 1 April 1984Volume 100, Issue 4Page: 622-623KeywordsComputers ePublished: 1 December 2008 Issue Published: 1 April 1984 PDF downloadLoading ...
From Pigsties to Hog Heaven?
Authors: David A. Taylor
Journal: Environmental Health Perspectives (2001)

In the continuing transformation of U.S. agriculture, North Carolina finds itself on the front edge of change. Between 1989 and 1998, the number of hogs in the state's pork industry quintupled---and so has the amount of hog waste that must be disposed of. Now the state has engaged private and public resources in a rapid search for better ways for handling hog waste. A technology review panel has approved the first round of proposals for a number of novel technologies to be developed through funds from a government-industry agreement. A second batch of proposals is expected to be approved by late summer.
Pulmonary medicine
Authors: D. R. Dantzker
Journal: JAMA (1992)

In the last few years, there have been significant changes in our understanding of the pathophysiology and approach to treatment of a number of pulmonary disorders. In 1981, heart-lung transplantation was introduced as the first truly viable option for the long-term treatment of pulmonary hypertension secondary to primary pulmonary hypertension and Eisenmenger's syndrome. In the short time since then, breakthroughs in surgical techniques and the availability of cyclosporine have permitted a number of new transplantation techniques, including single-lung, double-lung, and now bilateral sequential lung transplants. Single-lung replacement initially was recommended only for patients with end-stage interstitial lung disease. The transplant procedure improved overall function, and the use of only one lung simplified the surgical technique compared with heart-lung transplantation, lowering the perioperative morbidity and mortality and increasing the number of organs available for transplantation. Initially, it was thought that a single-lung transplant would be inappropriate for patients with associated cor
TYPHOID FEVER IN MILITARY CAMPS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DEMAND AND SUPPLY OF PHYSICIANS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ecstasy-Fueled 'Rave' Parties Become Dances of Death For English Youths
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Controlled study of the cytotoxic food test
Authors: P. Lieberman
Journal: JAMA (1975)

The cytotoxic food test was not found to be an accurate method for diagnosing atopic reactions to foods. Claims that the test correlated with other untoward reactions to foods (eg, headache, diarrhea, fatigue) could not be corroborated. The test itself is time-consuming, dependent on subjective interpretation, and inconsistent in results when repetitive runs are performed on the same patient. (<i>JAMA</i>231:728-730, 1975)
The Cabalist
Authors: Michael A. Lacombe
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sweat tests
Authors: J. M. Hicks
Journal: JAMA (1979)

<h3>To the Editor.—</h3> I feel obliged to reply to Dr Shwachmann's letter (240:2731, 1978) regarding the high frequency of unreliable sweat tests for cystic fibrosis and his statement that the cause is the lack of interest of clinical chemists. I agree that sweat tests are frequently not performed reliably, but I wonder why the clinical chemist has been singled out as being responsible when most hospital laboratories are still directed by pathologists and not by professional clinical chemists. Certainly in our laboratory the sweat test is performed exactly as described by the Cystic Fibrosis Foundation in its publication,<i>Procedure for the Quantitative Iontophoretic Sweat Test for Cystic Fibrosis</i>, by Gibson, Sant' Agnese, and Shwachmann. We report the weight of sweat collected and the concentration of sodium and chloride and run the test twice. In addition to our laboratory, I know of many other hospital clinical chemistry laboratories in which the
IS THERE AN AMBLYOPIA EXANOPSIA?
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Manual of General Experimental Pathology, for Students and Practitioners.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Methods
Journal: JAMA Network Open (2020)

Xue Xu, PhD; Jianqiang Li, PhD; Jinfeng Zou, PhD; Xiaowen Feng, PhD; Chao Zhang, PhD; Ruiqing Zheng, MSc; Weixiang Duanmu, PhD; Arnab Saha-Mandal, PhD; Zhong Ming, PhD; Edwin Wang, PhD
ENDOWMENT OF MEDICAL EDUCATION.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal