tbuckley/cabot-search huggingface dataset:
EEG has diagnostic partner in MEG
Authors: Sana Siwolop
Journal: JAMA (1983)

To better understand how the brain's magnetic field might be used in medical diagnosis, scientists at the Massachusetts Institute of Technology (MIT), Cambridge, have produced simultaneous magnetoencephalogram (MEG) and electroencephalogram (EEG) maps of two human heads. A comparison of the two volunteers' brain mappings demonstrates the differences between the EEG, which records the electrical potential on the scalp, and the MEG, which records the magnetic field produced by the same electrical activity. The MEG seems to be most useful when it complements information provided by the EEG; by itself it does not pinpoint electrical activity much better than the EEG. According to physicist David Cohen, PhD, and electrical engineer B. Neil Cuffin, PhD, there are several major differences between the two types of signals (<i>Electroencephalogr Clin Neurophysiol</i>1983; 56:38-51). The first is that, although both the EEG and the MEG result from the same electrical activity in the brain, the
Oxygen tensions in normal and ischemic tissues during hyperbaric therapy. Studies in rabbits
Authors: N. B. Ackerman
Journal: JAMA (1966)

The maintenance of adequate tissue oxygenation becomes an overwhelming problem in the presence of certain disease and traumatic states. Various cardiovascular, pulmonary, bacterial, and toxic conditions imperil the normal flow of oxygen to the tissue and can threaten the survival of organ systems and life itself. In the presence of severe trauma with disruption of circulation, loss of life or limb may occur unless there is rapid restoration of tissue oxygenation. There has recently been considerable interest in the use of hyperbaric oxygen as a means of improving oxygen tensions in normal and diseased tissues. This present study was an attempt to quantitate changes in oxygen tensions during hyperbaric therapy in normal tissues and in tissues with an inadequate blood supply. It is our feeling that with basic, experimental studies of this type the uses and limitations of hyperbaric oxygen therapy will be better understood. <h3>Methods</h3> Studies were performed on
Metastatic patterns and prognostic significance of signet ring cell carcinoma of the colon: Retrospective analysis of SEER database.
Authors: John Khoury, Rebecca Chacko, David Macari, Bolanle Gbadamosi, Daniel Ezekwudo, Leann Blankenship, Joseph M Anderson, Ishmael A. Jaiyesimi
Journal: Journal of Clinical Oncology (2018)

e15594 Background: Signet ring cell carcinoma of the colon (SRCC) represents less than 1% of all colon carcinomas. We retrospectively examined the metastatic patterns and prognosis of SRCC in comparison to adenocarcinoma (AC) of the colon. Methods: A total of 763 patients diagnosed with SRCC and 42,875 patients with AC of the colon from 2010 to 2012 were identified from the Surveillance, Epidemiology and End Results (SEER) database. Age, race, gender, primary site, grade, stage, metastatic site and survival data were collected. Results: Out of 43,638 patients, 78.7 % were white, 12.5 % black and 8.8% other races. Median age of diagnosis was 67.5 years for SRCC as compared to 69.1 years for AC . SRCC was more likely to be grade III or IV (92% vs 21.6%; p < 0.001), to be found in the right colon (63.7% vs 49.4%; p < 0.001) and to present as advanced stage (40.2% vs 29.4% for stage III and 37.1% vs 22.3% for stage IV; p < 0.001). SRCC was more likely to present with metastases to the brain (11.0% vs 1.3%; p < 0.001) and bone (6.4% vs 4.1%; p < 0.001), while AC subjects were more likely to present with metastases to the liver (77.0% vs 22.1%; p < 0.001) and lung (21.2% vs 5.8%; p < 0.001). The 5 year overall survival rate (5-YSR) was 28.2% (CI, 24.5% to 32.4%) for SRCC compared to 50.8% (CI, 50.1% to 51.6%) for AC (Hazard ratio for death, 1.38; CI, 1.26 to 1.52; P < 0.001). The differences in stage specific 5-year survival rates for SRCC and AC were not statistically significant for stage I and stage II. However, SRCC had a lower 5-YSR for stage III (34.5% vs 55.4%) and stage IV (3.3% vs 10.8%). Conclusions: SRCC of the colon has worse survival rates for advanced stages when compared to AC. SRCC presents at earlier age, with advanced tumor grade and stage at diagnosis. The metastatic behavior of SRCC is different than AC with a higher incidence of brain and bone metastases at diagnosis.
Laboratory test results altered by "The Pill"
Authors: H. Weindling
Journal: JAMA (1974)

Oral contraceptive agents have many diverse and important extragenital effects, as manifested by alterations in laboratory test results. Drug therapy, as with oral contraceptive agents, is only one of many variables that must be considered in the knowledgeable interpretation and application of laboratory-generated data. (<i>JAMA</i>229:1762-1768, 1974)
Evaluation of an Association Between Loratadine and Hypospadias—United States, 1997-2001
Journal: JAMA (2004)

During 1993-2002, the average year-to-year decrease in TB rate was 6.8%.However, 2003 had the smallest annual decrease (1.9%), raising concern about a possible slowing of the progress against TB.During the preceding decade, certain key challenges to TB control were identified, including (1) an increasing proportion of TB among persons born in countries with high rates of TB, (2) disparities among racial/ethnic minority populations, and (3) unique TB epidemiologic trends found in localized areas throughout the United States.Birthplace data were first collected by the national TB surveillance system in 1986, when 21.8% of TB cases occurred among foreign-born persons.Since then, the proportion has increased steadily, with the highest proportion being reported in 2003, a trend enhanced by the decrease in TB cases among U.S.-born persons.Foreignborn TB patients also are more likely to have multidrug-resistant TB than U.S.-born patients, and the cost of caring for patients with multidrugresistant TB is high. 9CDC is collaborating with partners (e.g., U.S. Agency for International Development, International Union Against TB and Lung Disease, Royal Netherlands TB Association, and World Health Organization) to assist countries with high burdens of TB.CDC collaborations have focused on operational research and programmatic evaluation to address problems such as TB/human immunodeficiency virus coinfection and drug resistance in approximately 20 countries.CDC also is contributing to improvements in TB screening among immigrant and refugee visa applicants, both overseas and in the United States, through the development of innovative tracking mechanisms, new diagnostic tools, and updated medical screening guidelines.A CDCsponsored assessment of TB prevention among foreign-born persons is under way in 22 locations in the United States and Canada.
Cephaloridine
Authors: ROY T. STEIGBIGEL
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 February 1974CephaloridineROY T. STEIGBIGEL, M.D.ROY T. STEIGBIGEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-2-277_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent review of cephaloridine by Dr. G. L. Mandell (Ann Intern Med79:561-565, 1973) discusses the probable lack of effectiveness of cephalothin in the treatment of bacterial meningitis. However, two reports (1, 2) are cited in which pneumococcal meningitis is successfully treated with cephaloridine. It should be emphasized that in both of these reports cephaloridine was administered intrathecally to all patients, either daily or on alternate days for at least 1 week. In evaluating cephaloridine for the treatment of pneumococcal meningitis we should consider that intrathecal treatment was used in these studies, which is a route...References1. MCKENZIELOVEJAMIESON PWW: Cephaloridine in pneumococcal and other forms of pyogenic meningitis. Postgrad Med J 43 (suppl):142-145, 1967 Google Scholar2. LOVEMCKENZIELAWSON WPJ: Treatment of pneumococcal meningitis with cephaloridine. Postgrad Med J 46(suppl):155-159, 1970 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Infectious Diseases Unit Department of Medicine University of Rochester Medical School Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1974Volume 80, Issue 2Page: 277-277KeywordsBacterial meningitisMeningitis Issue Published: 1 February 1974 PDF downloadLoading ...
Acquired Zinc Deficiency
Authors: Stephen B. Tucker
Journal: JAMA (1976)

A patient given long-term total parenteral nutrition acquired a zinc deficiency severe enough to cause typical cutaneous manifestations of acrodermatitis enteropathica. This report, the first detailed one, to our knowledge, of such an association, adds to the accumulating evidence that supplementation of trace elements is needed in long-term parenteral nutrition. (<i>JAMA</i>235:2399-2402, 1976)
Obesity in children is associated with arterial endothelial dysfunction Kam S. Woo, Ping Chook, Rita Y. T. Sung, Chung W. Yu, Christopher W. K. Lam, Sophie S. F. Leung, Con Metreweli, David S. Celermajer. The Chinese University of Hong Kong, Hong Kong, Hong Kong, The Royal Prince Alfred Hospital, Sydney, Australia
Journal: Journal of the American College of Cardiology (2001)
Annals Otol, Rhinol, &amp;amp; Laryngology, St. Louis
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massive Adrenal Necrosis in Rats Caused by 9,10-Dimethyl-1,2-Benzanthracene and Its Inhibition by Metyrapone
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The physician's estate. Part II
Authors: B. Nortell
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re: Silke Gillessen, Gerhardt Attard, Tomasz M. Beer, et al. Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019. Eur Urol. 2020;77: 508–47 https://doi.org/10.1016/j.eururo.2020.01.012
Authors: Finn Edler von Eyben, Glenn Bauman, Cigdem Soydal, Giovanni Paganelli
Journal: European Urology (2020)
Uncoupling of biliary lipid from bile acid secretion by formyl- methionyl-leucyl-phenylalanine in the rat
Authors: K Mizuno, M Hoshino, T Hayakawa, H Yamada, T Nakazawa, T Inagaki, T Takeuchi, M Kunimatsu
Journal: Hepatology (1996)

A neutrophil chemotactic factor N–formyl–methionyl–leucyl–phenylalanine (fMLP), produced by Escherichia coli under conditions of intestinal inflammation, is reported to circulate enterohepatically in the presence of experimental colitis, but its effect on bile secretion is unclear. Therefore, we investigated the effect of fMLP on bile secretion in a single–pass isolated perfused rat liver system. Infusion of fMLP at different concentrations (2 μmol/L, 10 μmol/L, and 20 μmol/L) into the portal vein resulted in excretion into bile in the native form, independent of sodium taurocholate (1 μmol/min) infusion. Excretion of fMLP increased dose dependently, and approximately 12% of the infused dose was detected at each concentration. With constant infusion of sodium taurocholate (1 μmol/min), fMLP (20 μmol/L) increased bile flow but decreased phospholipid and cholesterol secretion. Bile acid secretion was not affected. Phospholipid/bile acid molar ratios decreased from 0.069 ± 0.002 to 0.038 ± 0.002, and cholesterol/bile acid molar ratios decreased from 0.0074 ± 0.0009 to 0.0029 ± 0.0008. Thus, administration of fMLP resulted in the uncoupling of biliary excretion of phospholipid and cholesterol from that of bile acids; this effect proved reversible. The increase in bile flow caused by fMLP infusion appeared to result from osmotic choleresis. When 25 mg of horseradish peroxidase, a conventional marker of transcytotic vesicle transport pathway, was infused for 1 minute as a pulse load into the portal vein after continuous infusion of taurocholate, its late peak excretion was reduced by fMLP (10 μmol/L) from 9.59 ± 1.09 to 6.05 ± 0.66 (ng/g liver). Gel–permeation chromatography of bile showed a specific association of fMLP with bile acids. These results suggest an uncoupling of biliary lipids from bile acids by fMLP because of inhibition of transcellular vesicle transport and interaction between fMLP and bile acid micelles in the bile canaliculus.
The role of dietary cholesterol and transfatty acids in the aetiology of gallstones: a uk prospective cohort study (EPIC-Norfolk) using 7-day food diaries
Authors: P. J. R. Banim, R. Luben, S. J. Sharp, N. J. Wareham, K.-T. Khaw, A. R. Hart
Journal: Gut (2011)

<h3>Introduction</h3> Dietary cholesterol may prevent gallstone formation by upregulating the enzyme cholesterol 7-α hydroxlase (Cyp7A1), which converts cholesterol to primary bile acids and prevents biliary cholesterol supersaturation, a prerequisite for cholesterol stone formation. Trans fatty acids promote hyperinsulinaemia which inhibits Cyp7A1 and could promote gallstone disease. This study investigated dietary cholesterol and trans fatty acid intake on the risk of developing symptomatic gallstones, for the first time using 7-day food diaries (7-DFDs), the most accurate feasible method of estimating food intake in large studies. <h3>Methods</h3> 25 639 participants (56% women), aged 40–74 years were recruited into the European Prospective Investigation into Cancer-Norfolk (EPIC-Norfolk) with 23 658 completing 7-DFDs at enrolment. The cohort was monitored for 14 years for new symptomatic gallstones, with diagnoses confirmed by review of the clinical notes. The 7-DFDs recorded 1 week9s diet including food types, frequency of consumption, quantities and cooking methods. A representative sample of 3 970 and those with gallstone disease had their 7-DFDs coded by nutritionists using a computer program containing nutrient information on 11 000 food and 55 000 portion sizes. A cohort analysis used Cox regression to estimate sex specific HRs for developing gallstones for fifths of dietary cholesterol and trans fatty acid intake, adjusted for known risk factors: age, body mass index, energy, alcohol and physical activity in men and also parity and hormone replacement therapy use in women. <h3>Results</h3> 177 women (mean age of diagnosis 66.5 years SD 9.5 years) and 90 men (64.2 years SD 9.2 years) developed symptomatic gallstones. In women, increased dietary cholesterol was associated with a decreased risk of disease (highest vs lowest fifth, HR 0.52, 95% CI 0.31 to 0.86, per fifth increase HR 0.83, 95% CI 0.74 to 0.93, p for trend=0.002), with no effect in men (trend across fifths HR 0.92, 95% CI 0.78 to 1.08). Increased trans fatty acid intake in women increased the risk of disease (highest vs lowest fifth, HR 2.18, 95% CI 1.21 to 3.92, per fifth increase HR 1.17, 95% CI 1.02 to 1.35, p=0.023), with no effect in men (trend across fifths HR 1.01, 95% CI 0.84 to 1.23). <h3>Conclusion</h3> In women, low dietary cholesterol and high trans fatty acid intake increased the risk of developing symptomatic gallstones, for which there are plausible biological mechanisms. No effects were found in men, though this could be due to a lack of power with only half the number of cases diagnosed. Dietary cholesterol and trans fatty acids should be measured in future aetiological studies of gallstones.
Phase II trial of high‐dose dexamethasone for previously treated immunoglobulin light‐chain amyloidosis
Authors: Morie A. Gertz, Martha Q. Lacy, John A. Lust, Philip R. Greipp, Thomas E. Witzig, Robert A. Kyle
Journal: American Journal of Hematology (1999)

Immunoglobulin light-chain amyloidosis (AL) is a rare disorder characterized by production of a monoclonal light chain. This insoluble light chain, or a fragment thereof, deposits in tissues as amyloid and results in disruption of organ function and, ultimately, in death. Although melphalan and prednisone are beneficial in approximately 30% of patients with the disease, many patients fail to respond, and the median survival with this disease remains < 2 years. There is a need for new agents for those patients who fail to respond to melphalan-based chemotherapy. A study was undertaken of high-dose dexamethasone in the treatment of 19 patients with AL because of reports of its benefits in previously untreated patients with amyloidosis and its known activity in the management of multiple myeloma, which has many characteristics in common with AL. In this cohort, 3 of 19 patients showed an objective organ response of the disease. The median survival of the entire group was 11.2 months. We conclude that high-dose dexamethasone therapy is of occasional benefit in patients previously treated for amyloidosis. Combining dexamethasone with other therapies may increase the response rate. Am. J. Hematol. 61:115–119, 1999. © 1999 Wiley-Liss, Inc.
Dermatologic conditions misdiagnosed as evidence of child abuse
Authors: Peter J. Koblenzer
Journal: JAMA (1989)

<h3>To the Editor. —</h3> The report by Mss Herman-Giddens and Berson<sup>1</sup>documenting traumatic genital care practices in children emphasizes once more the many and varied forms of child abuse. The putative numbers are mind-boggling and the harm done is immeasurable. As physicians, we must strive to the utmost to alleviate this intolerable situation, but scientific objectivity must not be sacrificed. I refer to case 3 in the article by Mss Herman-Giddens and Berson. It is clear that the behavior of the father is inappropriate and potentially harmful to the girl's psychosexual development. Examination of the photograph, however, points to a diagnosis of juvenile lichen sclerosus et atrophicus rather than the steroid effect suggested in the text. Of unknown etiology, evolution of the lesions takes place over a period of years, and resolution might not be complete until puberty. Symptoms that include burning micturition and chronic pruritus are common. I
In Vivo Diagnostic Testing and Immunotherapy for Allergy
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal