tbuckley/cabot-search huggingface dataset:
EGYPTIAN AND CNIDIAN MEDICINE
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE INTEGRATION OF THE EXACT SCIENCES IN ALLERGY RESEARCH
Journal: Annals of Internal Medicine (1945)

Article1 July 1945THE INTEGRATION OF THE EXACT SCIENCES IN ALLERGY RESEARCHLESLIE N. GAY, M.D., F.A.C.P.LESLIE N. GAY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-1-53 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSome years ago Dr. Abraham Flexner of the Rockefeller Institute, in conversation with the late Mr. George Eastman, asked him whom he regarded as the most useful worker in science in the world. Mr. Eastman replied without the least hesitation, "Marconi." Dr. Flexner surprised him by saying, "Whatever pleasure we derive from the radio or however wireless and the radio may have added to human life, Marconi's share was practically negligible." Mr. Eastman, a far-seeing and philanthropic gentleman, was planning to devote his vast fortune to the promotion of education in useful and exact sciences. He asked Dr. Flexner for... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication July 24, 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1945Volume 23, Issue 1Page: 53-64KeywordsAllergy and immunology ePublished: 1 December 2008 Issue Published: 1 July 1945 PDF downloadLoading ...
Electricity in the Diagnosis and Treatment of Diseases of the Nose, Throat and Ear. With 16 illustrations.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of young people in global health governance: an interview-based observational study
Authors: Christopher Pleyer, Roopa Dhatt, Renzo Guinto, Kelly A Thompson, Altagracia Mares de Leon, Johanne H Iversen, Michael W Kalmus Eliasz, Agostinho Sousa, Waruguru Wanjau
Journal: The Lancet Global Health (2013)
Hemorrhage following needle biopsy of kidney. Diagnosis by renal arteriography
Authors: M. Immergut
Journal: JAMA (1970)

Persistent gross hematuria following a diagnostic needle biopsy of the kidney should be investigated with intravenous urography and renal arteriography. Renal arteriography revealed the cause of postbiopsy hemorrhage which required early operative intervention in a 22-year-old man.
Development of Methods to Monitor Exposure to 1-Nitropyrene
Authors: Karam El-Bayoumy, Bruce Johnson, Ajit K. Roy, Pramod Upadhyaya, Syrus Partian, Stephen S. Hecht
Journal: Environmental Health Perspectives (1994)

On the basis of 32P-postlabeling analysis, treatment of rats with 1-nitropyrene (1-NP) resulted in the formation of multiple DNA adducts in the liver, mammary glands, and peripheral lymphocytes.The one adduct resulting from nitroreduction, N-(deoxyguanosin-8-yl)-1-aminopyrene, constitutes only a minor component among the adducts.In the present study, incubation of calf thymus DNA with mutagenic ring-oxidized metabolites of 1-NP in vitro in the presence and absence of xanthine oxidase also resulted in the formation of multiple adducts.On the basis of their chromatographic behavior, it appears that DNA adducts derived from such metabolites may have been formed in vivo; however, this needs to be confirmed.[3H]1-NP was given to male and female F344 rats and Sprague-Dawley rats by gavage at five dose levels in the range of 0.1 to 1000 pg/kg bw.This led to stable hemoglobin adducts accounting for 0.08 ± 0.05% of the dose (n = 3 rats).The radioactivity associated with hemoglobin following adminis- tration of [3H]1-NP was cleared with a half-life of about 14 days, which is faster than that of unmodified erythrocytes in the rat (t1/2= 30 days).Treatment of the hemoglobin with 1% HCI in acetone, to precipitate the globin, released the radioactivity; it was all bound to the heme moiety.The structures of the heme adducts have not been elucidated; yet, because of their stability, they may be useful as dosimeters for human exposure to 1-NP.The results of this study demonstrate the potential of using hemoglobin adducts of 1-NP as dosimeters of uptake and metabolic activation of nitropolynuclear aromatic hydrocarbons (NO2-PAH).These indicators are a prerequisite for cancer risk assessment of N02-PAH.-Environ Health Perspect 102(Suppl 6): 31-37 (1994) Key words: nitropyrene,
Effectiveness of new generation DAAs for HCV infection in a large cohort of Italian people who use drugs (PWID): the cleo-grecas real-world experience
Authors: Vincenzo Messina, Vincenzo Iovinella, Ernesto Claar, Valerio Rosato, Massimo De Luca, Giorgio Barbarini, Giuseppe Cariti, Tommaso Lupia, Mariano Quartini, Gianpiero D’Offizi, Ilaria Luzzitelli, Giustino Parruti, Federica Sozio, Gaetano Scifo, Marco Distefano, Tundo Paolo, Francesco Benanti, Lucio Cosco, Fabio Bulla, Giancarlo Gimignani, Maria Antonietta Di Rosolini, Valeria Pace Palitti, Umberto Vespasiani Gentilucci, Antonio Ascione, Michele Imparato, Luca Rinaldi, Riccardo Nevola, Vito Di Marco, Antonio Craxì, Valeria Morbiducci, Francesco Di Lorenzo, Riccardo Guarisco, Rodolfo Sacco, Antonio Izzi
Journal: Journal of Hepatology (2020)
Update: Blood Lead Levels— United States, 1991-1994
Journal: JAMA (1997)

Lead is an environmental toxicant that may deleteriously affect the nervous, hematopoietic, endocrine, renal, and reproductive systems. Lead exposure in young children is a particular hazard because children absorb lead more readily than do adults and because the developing nervous systems of children are more susceptible to the effects of lead. Blood lead levels (BLLs) at least as low as 10 micrograms/dL can adversely affect the behavior and development of children. CDC's National Health and Nutrition Examination surveys (NHANES), an ongoing series of national examinations of the health and nutritional status of the civilian noninstitutionalized population, have been the primary source for monitoring BLLs in the U.S. population. From NHANES II (conducted during 1976-1980) to Phase 1 of NHANES III (conducted during October 1988-September 1991), the geometric mean (GM) BLL for persons aged 1-74 years declined from 12.8 micrograms/dL, and the prevalence of elevated BLLs (BLLs > or = 10 micrograms/dL) decreased from 77.8% to 4.4%. This report updates national BLL estimated with data from Phase 2 of NHANES III (conducted during October 1991-September 1994), which indicate that BLLs in the U.S. population aged > or = 1 year continued to decrease and that BLLs among children aged 1-5 years were more likely to be elevated among those who were poor, non-Hispanic black, living in large metropolitan areas, or living in older housing.
Journal of Bone and Joint Surgery, Boston
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lethal air embolism from plastic blood-storage container
Authors: A. E. Yeakel
Journal: JAMA (1968)

A 50-year-old man suffered lethal air embolism during a carotid endarterectomy performed with the patient under general anesthesia. The embolized air probably gained access to a plastic blood bag when the administration set which drained the bag was changed<i>during</i>transfusion. The air entering a blood bag during venting was measured as a function of the volume of blood remaining. The greatest volume of air measured was 136 ml which was entrapped in a bag holding 200 ml of blood.
Editor's quiz: GI Snapshot
Authors: C Thirunavukkarasu, Y Yang, M Subbotin, C Gandhi, M Brookes, K Sharma, C Tselepis, T Iqbal, M Bramble, J Ironside, N Krikis, K Tziomalos, V Perifanis, S Vakalopoulou, A Karagiannis, V Garipidou, F Harsoulis, U Siebert
Journal: Gut (2004)
No support for moderate drinking improving health
Journal: BMJ (1999)

Women should be advised to allow adequate time after stillbirth before next pregnancy Some clinicians have argued that women need time to recover emotionally after stillbirth and before beginning the next pregnancy, but without systematic evidence to support this.In a cohort study (p 1721) Hughes et al found that in the pregnancy after stillbirth women showed significantly higher depression and state anxiety in the third trimester than control women, and that the difference was accounted for by women who conceived within 12 months after the stillbirth.These women were also more depressed 1 year after the next birth.Women who conceived more that 12 months after stillbirth were similar to their controls at all points.Women may need a year to recover after stillbirth-or perhaps those who become pregnant quickly are more vulnerable to depression and anxiety.
Psychopathology.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood Groups and Enzymes of Human Red Cells After a Year's Storage in Liquid Nitrogen
Authors: R. G. Huntsman, B. A. L. Hurn, E. W. Ikin, H. Lehmann, J. Liddell
Journal: BMJ (1962)

DUMPING SYNDROME this alteration has not occurred spontaneously a period on insulin treatment might induce the requisite adaptation.SummaryIn seven patients with the post-gastrectomy dumping syndrome a pre-cibal injection of insulin was shown to reduce the post-cibal fall in plasma volume, at the same time relieving their symptoms.Thirty-three patients with the dumping syndrome were treated with insulin before one or two meals a day.All but three showed some benefit, though in only 14 was tbi$i definite: of these, six were able, after a while, to give up treatment without relapse.The possible mechanism by which insulin achieves these effects is discussed.In patients with the dumping syndrome it appears that their carbohydrate metabolism has failed to adapt to the new circumstances produced by the operation.It is concluded that insulin treatment is of benefit in some patients with the dumping syndrome.
Dietary Protein Effects on Cadmium and Metallothionein Accumulation in the Liver and Kidney of Rats
Authors: Nathaniel W. Revis, Tanya R. Osborne
Journal: Environmental Health Perspectives (1984)

The relationship of dietary protein to cadmium absorption and tissue deposition was studied in male Sprague-Dawley rats exposed to different levels of cadmium in the drinking water. In animals fed a high-protein or low-protein diet and drinking water containing 25 or 50 ppm cadmium, liver and kidney cadmium and metallothionein were both significantly higher in rats fed the high-protein diet for 2 to 4 months. These differences may possibly be explained by the concentration of cysteine observed between these two diets. When cysteine was added to the low-protein diet to the level observed in the high-protein diet and fed to rats receiving 25 ppm cadmium in the drinking water, significant dietary differences in liver and kidney cadmium and metallothionein were not observed. The importance of dietary protein to cadmium-induced toxicity was also assessed in these studies. The activity of catechol-o-methyltransferase was used as a measure of cadmium-induced toxicity. The activity of this enzyme in the lung, liver and heart was significantly lower in rats fed a low-protein diet than those fed the high-protein diet and 50 ppm cadmium. Metallothionein concentration in the lung and liver from low-protein-fed rats was approximately half the level observed in rats fed the high-protein diet, which suggests a relationship between cadmium-induced toxicity and metallothionein concentrations. These results illustrate the importance of considering dietary protein (and possibly cysteine) when studying cadmium metabolism in experimental animals.
Campotomy in Various Extrapyramidal Disorders
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Carcinogenic Potency Database: Analyses of 4000 Chronic Animal Cancer Experiments Published in the General Literature and by the U.S. National Cancer Institute/National Toxicology Program
Authors: Lois Swirsky Gold, Thomas H. Slone, Neela B. Manley, Georganne Backman Garfinkel, Estie S. Hudes, Lars Rohrbach, Bruce N. Ames
Journal: Environmental Health Perspectives (1991)

The Carcinogenic Potency Database (CPDB) is an easily accessible, standardized resource of positive and negative long-term animal cancer tests. The CPDB has been published in four earlier papers that include results for approximately 4000 experiments on 1050 chemicals. This paper describes the CPDB: goals, inclusion criteria, fields of information, and published plot format. It also presents an overview of our published papers using the CPDB. The CPDB as published in plot format readily permits comparisons of carcinogenic potency and many other aspects of cancer tests, including for each experiment the species and strain of test animals, the route and duration of compound administration, dose level and other aspects of experimental protocol, histopathology and tumor incidence, TD50 (carcinogenic potency) and its statistical significance, dose response, author's opinion about carcinogenicity, and literature citation. A combined plot of all results from the four separate papers, which is ordered alphabetically by chemical, is available from L. S. Gold, in printed form or on computer tape or diskette. A computer readable (SAS) database is also available. The overview of papers includes descriptions of work on methods of estimating carcinogenic potency, reproducibility of results in near-replicate cancer tests, correlation in potency between species, ranking possible carcinogenic hazards, comparison of positivity and target organ in rats and mice, comparison of mutagens and nonmutagens, proportion of chemicals positive in animal tests, natural compared to synthetic chemicals, and mechanistic issues in interspecies extrapolation.
THE JUBILEE MEETING.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurolymphomatosis
Authors: J. M. Baehring, D. Damek, E. C. Martin, R. A. Betensky, F. H. Hochberg
Journal: Neuro-Oncology (2003)

The term “neurolymphomatosis” (NL) has included infiltration of the peripheral nervous system by lymphoma and nontumor lymphocytes. We describe NL as a lymphoma entity that affects cranial and peripheral nerves and roots. We reviewed the medical records of patients at the Massachusetts General Hospital (MGH) who registered between 1972 and 2000, as well as cases published in the English-language literature. Inclusion criteria were (A) histopathologic demonstration of lymphoma within peripheral nerve, nerve root/plexus, or cranial nerve or (B) CT/MRI or intraoperative evidence of nerve enlargement and/or enhancement beyond the dural sleeve in the setting of prior or concurrent lymphoma in systemic or CNS sites. We identified 25 patients with NL in addition to 47 reported by others. Four clinical presentations were (1) painful involvement of nerves or roots, (2) cranial neuropathy with or without pain, (3) painless involvement of peripheral nerves, (4) painful or painless involvement of a single peripheral nerve. Twenty of our patients and 44 of those reported had histopathologic confirmation of lymphoma infiltrating root or nerve. In the remainder, diagnosis was based upon clinical presentation, nodular nerve enlargement or enhancement, and lymphoma cells in spinal fluid or extraneural sites. For antemortem diagnosis, imaging studies were of greatest utility, followed by biopsy. Thirty-three patients of the combined series were not correctly diagnosed until postmortem examination. Systemic chemotherapy was used to address the multiple potential sites of involvement. When properly treated, NL carries a prognosis similar to primary CNS lymphoma in the modern era.
Viral infection may lead to vessel wall problems
Authors: P. Gunby
Journal: JAMA (1984)

A link was drawn between viruses, vasculitis, and possibly thrombosis in other research on the inflammatory process reported at the American Heart Association's Florida forum Douglas B. Cines, MD, University of Pennsylvania School of Medicine, Philadelphia, says he and colleagues used human umbilical vein endothelial cell cultures to "establish that infection with herpes simplex type 1 virus programs the endothelial cell to produce large quantities of viral proteins." As the virus replicates within the endothelium, he says, "these viral proteins become inserted into the surface of the endothelial cell, where they bind antibodies and/or complement-coated immune complexes. This enhanced binding of immune complexes could attract activated complement proteins and leukocytes from the circulation. In turn, these two systems are capable of initiating inflammation." Furthermore, Cines says, the resulting "immunologic endothelial cell injury could initiate platelet adherence. In turn, this adherence may lead to the thromboses that occur in certain vasculitic