tbuckley/cabot-search huggingface dataset:
Epidemic Malaise
Authors: W. H. Kelleher
Journal: BMJ (1970)

Background: Tissue microarrays (TMAs) are an attractive alternative to analysis of whole sections (WS). For breast carcinomas, the recent recommendations for cut-offs (i.e. Ki67, H-score) have necessitated the re-evaluation of TMAs. Materials and Methods: TMA results of immunohistochemistry (IHC) and Fluorescence in situ hybridization (FISH) testing for Estrogen receptors (ER), Progesterone receptors (PgR), Ki67 and HER2 were compared against the results of WS for 88 breast carcinomas. Results: We found excellent agreement between the two methods for ER and PgR IHC evaluation, using the H-score (Kappa coefficient 0.972 and 0.9, respectively). There was also excellent correlation for HER2 IHC (Kappa coefficient 1) and amplification (Kappa coefficient 0.933). Furthermore, scoring of Ki67 was highly-correlated between TMAs and WS (Kappa coefficient 0.954). The latter excellent correlation has not, to our knowledge, been previously reported. Conclusion: For breast cancer, TMAs are an efficient and reliable alternative to the use of WS, using the currently recommended markers, evaluation protocols and cut-off values.
Die Friedmann-Methode. Kritische beleuchtet unter Berücksichtigung der gesamten Friedmann-Literatur. Referat erstattet im Auftrag des staatlichen Ausschusses zur Prüfung des Friedmannschen Heil- und Schutzmittels gegen Tuberkulose.
Journal: JAMA (1923)

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Case 12-2014: A 59-Year-Old Man with Fatigue, Abdominal Pain, Anemia, and Abnormal Liver Function
Authors: Richard Furman, Pin Lu, Menu Setty, R Perez, Ailin Guo, Joelle Racchumi, Guozhou Xu, Jiao Ma, Susanne Steggerda, Morton Coleman, Christina Leslie, Y Wang
Journal: New England Journal of Medicine (2014)

corrections kinase activity.Introduction of the recombinant nonmutant and C481S BTK constructs into HEK 293 cells showed that phosphorylation of C481S BTK at Y223 became significantly less sensitive to ibrutinib inhibition than the nonmutant BTK did (half-maximal inhibitory concentration, 1006 nM vs. 2.2 nM) (Fig. 1B).Taken together, our data indicate that the C481S mutation disrupts the covalent binding between BTK and ibrutinib.The impaired binding leads to a loss of inhibition of BTK enzymatic activity that ultimately results in ibrutinib resistance in the patient.Consistent with the findings reported in the Journal by Woyach et al., 6 our studies confirm that BTK is a relevant pharmacologic target of ibrutinib from a genetic perspective.
CHRONIC APPENDICITIS WITHOUT DEFINITE ATTACKS.
Journal: JAMA (1907)

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THE COMPOSITE NATURE OF VITAMIN B
Journal: JAMA (1927)

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Psychological Services in Hospices in the UK and Republic of Ireland
Authors: A Price, M Hotopf, I J Higginson, B Monroe, M Henderson
Journal: Journal of the Royal Society of Medicine (2006)

Objective To evaluate the level of psychological services available to patients and staff in hospices. Design Questionnaire analysis. Setting Hospices in the UK and Republic of Ireland. Participants 224 hospices. Main outcome measures The availability of professional psychological support for those with advanced disease. Results Responses were received from 166 hospices (74%). Only 50 hospices (30%) have access to a psychiatrist, whilst 68 (41%) have access to a clinical psychologist and 92 (45%) have neither. Only 21 hospices (12%) have service level agreements with local mental health trusts. Counsellors, complementary therapists and spiritual advisors such as chaplains were more plentiful. Conclusions Delivery of the NICE guidelines, especially tier four, may be compromised by limited availability of specialist services. This has implications for the psychological assessment of applicants for voluntary euthanasia under an Assisted Dying Act.
Of references
Journal: JAMA (1966)

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Heat-Wave—Related Mortality—Milwaukee, Wisconsin, July 1995
Journal: JAMA (1996)

During July 12-15, 1995, a heat wave occurred in major portions of the midwestern and eastern United States. Record-high temperatures were recorded at approximately 70 locations, ranging from the central and northern Great Plains to the Atlantic coast and caused substantial numbers of heat-related illnesses and deaths in some locations. In Milwaukee, Wisconsin (1994 estimated population: 938,112), maximum daily temperatures ranged from 91 F (32.7 C) to 103 F (39.5 C), and average daily humidity was as high as 70%. This report summarizes the investigation by the Milwaukee County Medical Examiner's Office (MCMEO) and the Milwaukee Department of Health and Social Services of heat-related deaths in Milwaukee during the heat wave and presents four case reports.
Sex, History
Journal: JAMA (2002)

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Provision of hearing aids: does specialist assessment cause delay?
Journal: BMJ (1989)

family to be in excess of that in his two brothers.We counted all moles (incluiding those <3 mm and ¢3 mm diameter) in the patient, his identical twin, and his other brother aged 16 years (table) and observed an excess of moles in the patient.All three brothers had identical skin types and had had the same lifestyle and exposure to sun in that all had spent their earl childhood in Germanx, four weeks in Hong Kong and two weeks in Spain, but the rest of their lives in the United Kingdom.Nu mbers oJ moles in the threev siblitlgs Patient Idenitical twin Brother
Quality in Biliary and Pancreatic Endoscopy Meeting – Critical Appraisal
Journal: Endoscopy (2019)

The Portuguese Society of Digestive Endoscopy (SPED) organized its’ second Quality Meeting in 20th September 2019. This one-day meeting debated some of the performance measures suggested in the 2018 publication “Performance measures for ERCP and endoscopic ultrasound: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative” [1]. The initial conference, “How to audit quality in pancreatobiliary endoscopy” was presented by Lars Aabaken. During the day the 134 participants debated multiple other themes about ERCP and Endoscopic Ultrasonography. A final Quizz was won by three participants that received an inscription in the 3rd Quality Meeting that will take place in 18th September 2020, and colonoscopy will be the main focus.
Cancer: Its Origin, Its Development and Its Self-Perpetuation: The Therapy of Operable and Inoperable Cancer in the Light of a Systemic Conception of Malignancy. A Research.
Journal: JAMA (1931)

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Farmers and Gardeners: What Everyone Should Know
Journal: JAMA (1973)

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Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation
Authors: Matthew R. Hayes, Theresa M. Leichner, Shiru Zhao, Grace S. Lee, Amy Chowansky, Derek Zimmer, Bart C. De Jonghe, Scott E. Kanoski, Harvey J. Grill, Kendra K. Bence
Journal: Cell Metabolism (2016)
Twentieth Century Practice. An International Encyclopedia of Modern Medical Science. By Leading Authorities of Europe and America.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling
Authors: Sarah L. Gray, Christine Donald, Arif Jetha, Scott D. Covey, Timothy J. Kieffer
Journal: Endocrine Reviews (2010)

The adipocyte hormone leptin acts centrally and peripherally to regulate body weight and glucose homeostasis.The pancreatic ␤-cell has been shown to be a key peripheral target of leptin, with leptin suppressing insulin synthesis and secretion from ␤-cells both in vitro and in vivo.Mice with disrupted leptin signaling in ␤-cells (lepr flox/flox RIPcre tgϩ mice) display hyperinsulinemia, insulin resistance, glucose intolerance, obesity, and reduced fasting blood glucose.We hypothesized that hyperinsulinemia precedes the development of insulin resistance and increased adiposity in these mice with a defective adipoinsular axis.To determine the primary defect after impaired ␤-cell leptin signaling, we treated lepr flox/flox RIPcre tgϩ mice with the insulin sensitizer metformin or the insulin-lowering agent diazoxide with the rationale that pharmacological improvement of the primary defect would alleviate the secondary symptoms.We show that improving insulin sensitivity with metformin does not normalize hyperinsulinemia, whereas lowering insulin levels with diazoxide improves insulin sensitivity.Taken together, these results suggest that hyperinsulinemia precedes insulin resistance in ␤-cell leptin receptor-deficient mice, with insulin resistance developing as a secondary consequence of excessive insulin secretion.Therefore, pancreatic ␤-cell leptin receptor-deficient mice may represent a model of obesity-associated insulin resistance that is initiated by hyperinsulinemia.
Characteristics of long-term and short-term survivors of metastatic renal cell carcinoma (mRCC) treated with targeted therapy: Results from the International mRCC Database Consortium.
Authors: Wanling Xie, Toni K. Choueiri, Jae-Lyun Lee, Lauren Christine Harshman, Georg A. Bjarnason, Jennifer J. Knox, Mary J. MacKenzie, Lori Wood, Ulka N. Vaishampayan, Takeshi Yuasa, Min-Han Tan, Sun Young Rha, Frede Donskov, Neeraj Agarwal, Christian K. Kollmannsberger, Scott A. North, Brian I. Rini, Daniel Yick Chin Heng
Journal: Journal of Clinical Oncology (2012)

4538 Background: Patients with mRCC have variable courses in terms of survival and response to targeted therapy. The patients at the two extremes of the survival spectrum need to be characterized. Methods: 2,161 patients with mRCC treated with targeted therapy were examined. 152 patients who survived 4 years or more after the initiation of targeted therapy (long-term) were compared with 218 patients who survived 6 months or less (short-term) over the same time period (2004-2007). Results: Long-term survivors had fewer poor prognostic factors (PFs) such as Karnofsky performance status (KPS) &lt;80%, diagnosis to treatment interval&lt;1 yr, hypercalcemia, anemia, thrombocytosis and neutrophilia (all p&lt;0.0001). Patients with favorable prognosis who responded to targeted therapy were more likely to be long term survivors. For those in the intermediate risk group, patients who were long-term survivors were more likely to have only 1 poor prognostic factor (73% vs. 28%, p&lt;0.0001) and KPS≥80% (88% vs. 69%, p=0.009) compared to those in the short term survivor group. On multivariable analysis adjusting for PFs, response to targeted therapy (PR or better) significantly predicted long term survivor status (odds ratio=6.3, 95% CI: 2.3,17.4, p=0.0004). Conclusions: Long term survivors had a higher response rate to targeted therapy, a longer treatment duration and more use of second-line targeted therapy. Baseline prognostic criteria may be able to discriminate between long- and short- term survivors. [Table: see text]
Activation Mechanisms of STAT5 by Oncogenic Flt3-ITD.
Authors: Chunaram Choudhary, Christian Brandts, Joachim Schwable, Lara Tickenbrock, Bulent Sargin, Andrea Ueker, Frank D. Bohmer, Wolfgang E. Berdel, Carsten Müller-Tidow, Hubert Serve
Journal: Blood (2006)
Polluting the Universe
Journal: JAMA (2016)

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Committee on Immunization Practices: PedvaxHIB© Lots With Questionable Immunogenicity
Journal: JAMA (1992)

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