ERYTHROPOIETIN
Authors: MILTON S. SACKS
Journal: Annals of Internal Medicine (1958)

Editorial1 January 1958ERYTHROPOIETINMILTON S. SACKS, M.D.MILTON S. SACKS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-1-207 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent studies from a variety of sources would seem to establish the existence of a humoral substance capable of stimulating erythropoiesis and, under certain experimental conditions, even producing a polycythemic state. In contradistinction to certain essential metabolites such as iron, folic acid, and cyanocobalamin which may be looked upon as necessary building blocks for erythrocyte maturation, the plasma erythropoietic stimulating factor seems to be fundamentally concerned in the regulatory mechanism which maintains the remarkable constancy of the red cell mass in health, which stimulates erythropoiesis after hemorrhage or after exposure to an atmosphere of reduced oxygen tension, which inhibits the...1 CarnotDeflandre PC: Sur l'activité hemopoietique du serum, Compt. rend. Acad. d. sc. 143: 384, 1906. Google Scholar2 BonsdorffJalavista EE: On the humoral mechanism in anoxic erythrocytosis, Acta physiol. Scandinav. 16: 150, 1948. CrossrefGoogle Scholar3 GrantRoot WCWS: Fundamental stimulus for erythropoiesis, Physiol. Rev. 32: 449, 1952. CrossrefMedlineGoogle Scholar4 HurtadoMerinoDelgado ACE: Influence of anoxemia on the hemopoietic activity, Arch. Int. Med. 75: 284, 1945. 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Proc. 5: 89, 1957. Google Scholar35 GurneyPierceSchrierCarsonJacobson CWMISEPELO: The stimulatory effect of "anemic plasma" in congenital hypoplastic anemia, J. Lab. and Clin. Med. 50: 821, 1957. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MILTON S. SACKS, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEndokarditis durch Candida parapsilosisFACTORS CONTROLLING HEMOPOIESIS: EXPERIMENTAL OBSERVATIONS ON THEIR ROLE IN POLYCYTHEMIA VERA*JAMES W. LINMAN, M.D., FRANK H. BETHELL, M.D., F.A.C.P., MARTHA J. LONG, M.S.SOME OBSERVATIONS ON THE STIMULATION OF ERYTHROPOIESIS BY HUMORAL FACTORS 1 January 1958Volume 48, Issue 1Page: 207-212KeywordsBlood plasmaCyanocobalaminErythropoiesisErythropoietinFolic acidHemorrhageMetabolitesOxygenPlasma cells ePublished: 1 December 2008 Issue Published: 1 January 1958 PDF downloadLoading ...