tbuckley/cabot-search huggingface dataset:
History of Prostitution Among All the Peoples of the World, From the Most Remote Antiquity to the Present Day. Three volumes.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Table 1
Journal: JAMA Internal Medicine (2019)

Cindy N. Roy, PhD; Peter J. Snyder, MD; Alisa J. Stephens-Shields, PhD; Andrew S. Artz, MD, MS; Shalender Bhasin, MD; Harvey J. Cohen, MD; John T. Farrar, MD, PhD; Thomas M. Gill, MD; Bret Zeldow, MS; David Cella, PhD; Elizabeth Barrett-Connor, MD; Jane A. Cauley, DrPH; Jill P. Crandall, MD; Glenn R. Cunningham, MD; Kristine E. Ensrud, MD, MPH; Cora E. Lewis, MD, MPH; Alvin M. Matsumoto, MD; Mark E. Molitch, MD; Marco Pahor, MD; Ronald S. Swerdloff, MD; Denise Cifelli, MS; Xiaoling Hou, MS; Susan M. Resnick, PhD; Jeremy D. Walston, MD; Stephen Anton, PhD; Shehzad Basaria, MD; Susan J. Diem, MD, MPH; Christina Wang, MD; Stanley L. Schrier, MD; Susan S. Ellenberg, PhD
Books Received
Authors: Richard Balon, David C. Mohr, Bonnie Spring, Kenneth E. Freedland, Victoria Beckner, Patricia Arean, Steven D. Hollon, Allan Abbass, Stephen Kisely, Kurt Kroenke, Judith Ockene, Robert Kaplan, J. Sanchez-Moreno, A. Martinez-Aran, R. Tabarés-Seisdedos, C. Torrent, E. Vieta, J.L. Ayuso-Mateos, P. Fusar-Poli, M. Broome, F. Barale, G. Stanghellini, Almut Zeeck, Stefanie Weber, Angelika Sandholz, Edda Wetzler-Burmeister, Michael Wirsching, Carl Eduard Scheidt, Armin Hartmann, Susanne Schaal, Thomas Elbert, Frank Neuner, Jean Cottraux, Ivan Druon Note, Florent Boutitie, Maud Milliery, Virginie Genouihlac, Sai Nan Yao, Brigitte Note, Evelyne Mollard, Françoise Bonasse, Ségolène Gaillard, Diane Djamoussian, Chantal de Mey Guillard, Alain Culem, François Gueyffier
Journal: Psychotherapy and Psychosomatics (2009)
Abstract 4793: WSD1227: A novel, oral bioavailable, brain penetrable and reversible VEGFR inhibitor for the treatment of primary and metastatic brain tumors
Authors: Jinqiang Zhang, Wei Zhong, Zhihua Mu, claire sun
Journal: Cancer Research (2018)

Abstract Occurrence of brain metastases (BM) has been reported in ~10% cancer patients as a later manifestation of the disease with incidence depending on the type of primary tumors1: about 20~40% in NSCLC and BC2,3 and &amp;lt;5% in CRC4,5 and ovarian cancer (OC)6. The incidence of BM is increasing in part due to the earlier diagnosis by using brain imaging techniques and the improved survival offered by systemic therapies. Patients with BM have a very poor prognosis and the overall survival is only several months after diagnosis. Surgery and radiotherapy either as single treatment or in combination are the most common options for the management of BM since many anticancer drugs cannot cross the blood-brain barrier (BBB). VEGFR2, upregulated in many cancers7,8, plays an important role in tumor angiogenesis. Anti-angiogenesis has been proved to be a good strategy to shrink tumor in many cancer treatments, such as bevacizumab in GBM, NSCLC, mBC, cediranib in OC, etc. However, those clinical validated anti-VEGF agents cannot cross BBB effectively due to either large molecule weight or being substrate of BBB efflux transporters. Herein, using our advanced medicinal chemistry with deep knowledge in CNS area, a BBB penetrable, selective and potent VEGFR2 inhibitor WSD1227 is discovered with biochemical IC50 against VEGFR1/2/3 at 0.69/0.35/0.41nM versus against other targets such as PDGFRα IC50 22.9nM, PDGFRβ IC50 19.4nM, cKit IC50 383nM, FLT3 IC50 555 nM and CSF1R IC50 1062nM. In-vitro MDCKII transfected cell assays demonstrated WSD1227 is not a substrate of P-gp or BCRP, two main efflux transporters on human BBB. Preclinical CNS PK studies confirmed good brain penetration of WSD1227 with Kp,uu,brain close to unity. WSD1227 possessed superior PK profile with sufficient free PK exposure to achieve target engagement in mice. Treatment of mice bearing SW620, a CRC xenograft in both subcutaneous (SC) and intracranial models with WSD1227 after oral dosing resulted in significant tumor growth inhibition (TGI). Similar TGI was observed in SKOV-3 bearing mice, an OC xenograft in both SC and intracranial models. No toxicity was observed in the animals during the treatment. Moreover, predicted human PK properties are very promising to offer sufficient target engagement at a pretty low dose in clinic. Taken together, our data provide a good rationale for WSD1227 to be developed toward clinic for the treatment of patients with BM whose primary tumors have already been controlled well by systemic therapies. Citation Format: Jinqiang Zhang, Wei Zhong, Zhihua Mu, claire sun. WSD1227: A novel, oral bioavailable, brain penetrable and reversible VEGFR inhibitor for the treatment of primary and metastatic brain tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4793.
OUR DAILY BREAD
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HAZARDS OF THE FIRST TRIMESTER
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Manual of Obstetrics.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of neurotoxicity between fractionated ICE and infusional ICE for relapsed/refractory lymphoma
Authors: C. H. Lim, H. Chow, W. Ong, M. Tao, H. J. Ng
Journal: Journal of Clinical Oncology (2004)

6718 Background: Previously we reported a high incidence of severe neurotoxic adverse events related to ifosfamide (IFX) in lymphoma patients receiving short infusions of IFX. Prolonged infusions of IFX has been suggested to be associated with a decreased risk of neurotoxicity. Methods: All relapsed/refractory Hodgkin's and Non-Hodgkin's lymphoma patients who received either fractionated ICE (D1–3: IFX 2g/m2 over 2h with an equivalent dose of mesna over 12h, carboplatin [AUC=5 divided equally between 3 days; max=800mg] over 1h, etoposide 75mg/m2 over 2h) or infusional ICE (IFX 5g/m2 over 24h D2, carboplatin AUC=5 over 1h D2, etoposide 100mg/m2/d over 2h D1–3, mesna 7.5g/m2 over 36h D2) between July 2001 and November 2003 were reviewed. Results: Six of 19 patients (7 of 56 courses) receiving fractionated IFX developed neurotoxicity. Symptoms included one or more of the following: confusion (n=7), mood alterations (n=3), hallucinations (n=2), and somnolence (n=4). Of these, grade 3 toxicities occurred in 3 cases: confusion (n=1), hallucinations (n=1), and somnolence (n=1). Renal impairment and albumin <30g/L were 2 identified independent risk factors in this cohort. Only 2 of 23 patients (3 of 58 courses) receiving infusional IFX developed neurotoxicity. In all 3 cases only grade 1 headaches were experienced. Neither of these 2 patients had any previously described risk factors for neurotoxicity. No patients with potential risk factors in the infusional group developed neurotoxicity: renal impairment (0/2 vs 5/6), albumin <30g/L (0/1 vs 4/7), hepatic impairment (0/12 vs 5/20), prior cisplatin exposure (0/19 vs 6/37), and electrolyte derangements (0/8 vs 4/23). Rituximab was not a risk factor in either cohort. Conclusions: Infusional IFX-based ICE protocols for treatment of relapsed or refractory lymphoma is associated with a lower incidence and severity of neurologic events. No significant financial relationships to disclose.
Glasgow Royal Maternity and Women's Hospital, Medical Report for the Year 1928.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CRIMINAL USE OF CHLORAL.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coma-Inducing Drug GHB May Be Reclassified
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for von Hippel-Lindau disease by DNA polymorphism analysis
Authors: G. M. Glenn
Journal: JAMA (1992)

<h3>Objective.</h3> —Von Hippel-Lindau (VHL) disease is a rare, inherited multisystem neoplastic disorder. There is no biochemical test available to distinguish VHL disease gene carriers from their healthy siblings. We evaluated DNA polymorphism analysis as a method for identifying disease gene carriers. <h3>Design.</h3> —Prospective comparison of the results of DNA analysis with a comprehensive clinical screening examination. <h3>Setting.</h3> —The Clinical Center of the National Institutes of Health. <h3>Patients.</h3> —Blood was collected from 182 members of 16 families with VHL disease. Forty-eight asymptomatic individuals, at risk of developing this hereditary illness (with an affected parent or sibling), were examined for occult disease at the Clinical Center of the National Institutes of Health and tested by DNA polymorphism analysis. <h3>Results.</h3> —DNA polymorphism analysis predicted nine disease gene carriers and 33 individuals with the wild-type (normal) allele among the 48 individuals at risk of developing VHL disease; the test was not informative in six individuals. All nine individuals predicted to carry the VHL gene had evidence of occult disease on clinical examination. There was no clinical evidence of VHL disease in 32 of 33 individuals predicted to carry the wild-type allele. <h3>Conclusions.</h3> —DNA polymorphism analysis can identify individuals likely to carry the VHL disease gene among asymptomatic members of disease families. This technique serves to focus attention on those individuals who require periodic medical examination and may help to alleviate the morbidity and mortality associated with this disease. (<i>JAMA</i>. 1992;267:1226-1231)
Aziza
Authors: Ruth Kannai
Journal: Annals of Internal Medicine (2006)

On Being a Doctor17 January 2006AzizaRuth Kannai, MDRuth Kannai, MDFrom Hebrew University, Jerusalem, Israel 91120.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-2-200601170-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Write it down. Write on the form that I'm ‘insane.’ You just have to check the box. It's for my kids' National Insurance benefits. ‘Permanently’—of course permanently, everybody in the village knows I'm crazy … certified crazy. Yeah, it's a 100% disability. And my daughter Sarah, who works for the National Insurance, sends me the forms to renew every year.“Me, I only have a nerves disease, not a stupidity disease. I was never in a loony bin. The fact is that I raised 8 kids who work and have families. Really, we're a very good family, even though my ... Author, Article, and Disclosure InformationAffiliations: From Hebrew University, Jerusalem, Israel 91120.Corresponding Author: Ruth Kannai, MD, PO Box 12272, Hebrew University, Jerusalem, Israel 91120; e-mail, [email protected]net.il. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOn the adhesion of HAp film on Ti substrate made by LALA method 17 January 2006Volume 144, Issue 2Page: 143-144KeywordsBrainEmotionsFoodHallucinationsHeartMemoryNervesNursesSchizophrenia ePublished: 17 January 2006 Issue Published: 17 January 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Death associated with ventricular arrhythmia and thioridazine hydrochloride
Authors: T. D. Giles
Journal: JAMA (1968)

Ventricular arrhythmia associated with the administration of thioridazine hydrochloride is thought to be the cause of death of a 19-year-old boy. There were changes in the repolarization portion of the electrocardiogram. High doses of thioridazine had been given in cases with fatal or nearly fatal outcomes, and there is a strong suggestion that when high doses of phenothiazines are required, thioridazine should be considered contraindicated.
Sweetness
Authors: Jack Coulehan
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Raccoon Parasite an Emerging Health Concern
Authors: J. Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal