tbuckley/cabot-search huggingface dataset:
A Critical Overview of Homeopathy
Authors: Wayne Jonas
Journal: Annals of Internal Medicine (2003)

Letters21 October 2003A Critical Overview of HomeopathyWayne Jonas, MDWayne Jonas, MDFrom Samueli Institute; Alexandria, VA 22314.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-8-200310210-00026-w4 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Dantas and colleagues point out that there are additional data beside those presented in our overview of homeopathy. Our purposely limited review omitted some less rigorous science. Determining the magnitude of adverse effects is even more difficult than determining efficacy since most studies are not designed to detect adverse effects. The rate of the latter is extremely low in homeopathy. A more fruitful approach than meta-analysis of efficacy studies is to investigate the potential toxic effects of homeopathic drugs in cell and animal studies (1). Likewise, homeopathic pathogenic trials or provings, while extensively reported in the literature, ...References1. Jonas WB, Ernst E. The safety of homeopathy.. In: Jonas WB, Levin JS, eds. Essentials of Complementary and Alternative Medicine. Philadelphia: Lippincott Williams & Wilkins; 1999:167-71. Google Scholar2. Walach H, Koster H, Hennig T, Haag G. The effects of homeopathic belladonna 30CH in healthy volunteersa randomized, double-blind experiment. J Psychosom Res. 2001;50:155-60. [PMID: 11316508] CrossrefMedlineGoogle Scholar3. Jacobs J, Jonas WB, Jimenez-Perez M, Crothers D. Homeopathy for childhood diarrhea: combined results and metaanalysis from three randomized, controlled clinical trials. Pediatr Infect Dis J. 2003;22:229-34. [PMID: 12634583] CrossrefMedlineGoogle Scholar4. Milburn MA. Homeopathic treatment of childhood diarrhea [Letter]. Pediatrics. author reply 777-8. 1996;97:777. [PMID: 8628631] MedlineGoogle Scholar5. Vickers AJ. Clinical trials of homeopathy and placebo: analysis of a scientific debate. J Altern Complement Med. 2000;6:49-56. [PMID: 10706236] CrossrefMedlineGoogle Scholar6. Jonas WB, Linde K. Conducting and evaluating clinical research in complementary and alternative medicine.. In: Gallin J, eds. Principles and Practice of Clinical Research. New York: Academic Pr; 2002:401-26. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Samueli Institute; Alexandria, VA 22314. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHomeopathy as a Therapeutic Option in SpaceHomeopathy as a Therapeutic Option in Space 21 October 2003Volume 139, Issue 8Page: W-76KeywordsClinical laboratory sciencesComplementary and alternative medicineDiarrheaDrugsHomeopathyPathogensResearch laboratoriesResearch quality assessmentScientistsWalking ePublished: 21 October 2003 Issue Published: 21 October 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Future surgery: minimal invasion
Authors: M. F. Goldsmith
Journal: JAMA (1990)

THE SPOTLIGHT at this year's Clinical Congress of the American College of Surgeons illuminated a therapeutic revolution. Hundreds of general surgeons at the meeting in San Francisco, Calif, watched films, took part in discussions, and visited exhibits all devoted to promoting minimally invasive surgery. In this operating technique, diseased organs are removed with only small incisions and the aid of laparoscopy or some comparable optical system. The advantages over traditional procedures in which the body is opened and observed directly are extolled by adept clinicians. They include less trauma and healing with little pain, shorter recovery time and rapid return to normal activities, minimal scarring, shorter or no hospital stay, and—say some—lower cost. At the meeting, surgeons-as-students participated in an instrument manufacturer's setup, trying to watch a video screen that displayed the insides of a "patient" (in this instance, a piece of chicken) while they inserted trocars and manipulated the
Imported tropical disease.
Journal: BMJ (1967)

would be detected at a very early stage and the appropriate treatment could be instituted.In general, the earlier the diagnosis the more effectual the treatment.7The approach seems at the moment to stand a better chance of improving recurrence and survival rates than is likely to be accomplished by any foreseeable changes in treatment.If used on a national scale, with the original methods, this scheme of early detection would require vast resources.The new simplification may overcome this difficulty and make a development of this nature more probable.
MASS-SCREENING PROGRAMS
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GENE-01. STABILITY OF ACTIONABLE MUTATIONS IN PRIMARY AND RECURRENT GLIOBLASTOMAS
Authors: Kaspar Draaisma, Aikaterini Chatzipli, Martin Taphoorn, Melissa Kerkhof, Astrid Weyerbrock, Marc Sanson, Ann Hoeben, Lukacova Slavka, Giuseppe Lombardi, Monique Hanse, Ruth Fleischeuer, Sieger Leenstra, Colin Watts, Thierry Gorlia, Vassilis Golfinopoulos, Johan Kros, Martin van den Bent, Ultan McDermott, Pierre Robe, Pim French
Journal: Neuro-Oncology (2017)

Efforts to improve patient survival in recurrent glioblastomas (GBMs) are often based on targeting the tumors acquired genetic changes. However, resections on recurrent GBMs are infrequently performed and molecular data is extrapolated from the initial tumor. We therefore initiated a large study to assess whether genetic changes of initial GBMs are still present at recurrence. DNA was isolated from pairs of initial and recurrent GBM (FFPE) tumor samples and sequenced on a panel of 419 cancer associated genes. We also determined EGFRvIII expression status and MGMT promoter methylation status. All patients were treated according to the Stupp protocol. Tumor pairs from 226 patients from 10 medical centers in six countries were included in the analysis. Median survival was 21.1 months and median time to second surgery 11.1 months. Higher age, greater lesion size at second surgery and steroid treatment were associated with poorer survival in the recurrent tumor. ~4% of tumors were IDH1 mutated (median OS 33.7 months). Of the 114 tumor pairs sequenced to date, 73 patients (64%) gained or lost a variant in a recurrent driver oncogene while the median retention rate of driver variants was 80%. Common genes with gained mutations include TP53 (13 patients) and NF1 (8 patients), common losses of mutations were found in EGFR (12 out of 23). EGFRvIII was expressed in 25.5% of initial tumors and was lost at recurrence in 50% of cases. Two patients developed a hypermutated tumor at recurrence (276 and 431 coding variants after 12 and 17 cycles of temozolomide respectively). Preliminary analysis indicates that there are distinct gains and losses in each tumor, including in some driver mutations at tumor recurrence. This has important consequences on the need for re-biopsies in targeted treatment studies in recurrent glioblastoma.
ON THE PATHOLOGY AND TREATMENT OF LARYNGO-TRACHEAL INFLAMMATION
Authors: R. Turner
Journal: BMJ (1854)

JULY 7, prise the seveal impressions essential to ideas of the had, the soft, the rough, the smooth, the hot, the cold, the moist, the dry, and so on.It is, moreover, through this senibility that we appreciate the state of the muscles- obtain the musdar setee.This fifth sense also is, presumably, awakened through the.vesicular extremities-the peripheral expansion of fibrous filaments.Whether the grey substance and white fibres originating and conducting common sensation be the same as those which subserve the spinal reflex function, is a question yet undecided.This much, however, may be admitted: the communicated impression ascends along the posterior columns of the spinal cord, and attains grey vesi- cular centres-the ganglia of common sensation.
TYPHOID FEVER IN CHICAGO.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapunzel Syndrome
Authors: E Ghoneem, A Mehrez Gad, G Shiha, A Elbasiuny
Journal: Endoscopy (2021)

Rapunzel Syndrome occur in up to 1/3 of tracheobezoar cases. It characterized by presence of the hair ball in the stomach with tail like extension to the intestine. The most common presentations are abdominal pain, nausea and vomiting, obstruction, and peritonitis. Rarely, weight loss, anorexia, hematemesis, and intussusceptions can occurred. We present a case of 28 years old female presented with refractory reflux symptoms and dyspepsia. EGD showed tracheobezoar with its tail extend deep to the duodenum. Laparoscopic gastrostomy of the anterior surface of the stomach and extraction of bezoar through pfenistil incision with stomach closure using staplers.
Associated risk factors do not prevent the beneficial effect of aggressive cholesterol lowering: post CABG trial
Authors: L. Campeau, G. Knatterud, D. Hunninghake, M. Domanski, C. White, J. Canner, J. Forrester, N. Geller, F. Gobel, J.A. Herd, B. Hoogwerf, Y. Rosenberg
Journal: Journal of the American College of Cardiology (1998)
ORIGINAL INVESTIGATIONS ON THE NATURAL HISTORY, (SYMPTOMS AND PATHOLOGY) OF YELLOW FEVER. 1854-1894.
Authors: JOSEPH JONES
Journal: JAMA (1895)

<h3>Chapter VIII.</h3><h3>EFFECTS OF JAUNDICE UPON THE FREQUENCY OF THE PULSE.</h3><h3>Case 1.</h3> —Malarial fever, dysentery and jaundice. A. F., age 32; native of Germany. Entered Charity Hospital Dec. 29, 1875. Had had intermittent fever. Says that he has been sick with intermittent fever and dysentery for fourteen days. Upon entrance presented a pale sallow, bloodless hue, and suffered from painful discharges from the bowels, of mucus and blood at regular intervals. On January 1, the patient showed a distinct yellow tinge of the skin and conjunctiva of the eyes, which gradually increased to the most intense jaundice in the course of ten days. The urine was heavily loaded with bile, but free from albumin. The pulse which had been rapid and feeble, ranging from 100 to 120, became much slower after the supervention of the jaundice. The effect of the bile in the blood upon the frequency of the
Retinal Detachment
Authors: Huan J. Chang
Journal: JAMA (2009)

Retinal DetachmentT he retina is a light-sensitive, transparent tissue located on the back wall of the eye.Light is focused on the retina by the cornea and the lens.The retina then converts the image into neural impulses and sends them to the brain via the optic nerve (the nerve connecting the eye to the brain).Retinal detachment is the separation of the retina from the tissues underneath it.It is important to distinguish retinal detachment from posterior vitreous detachment (when the jelly in the eye peels away from the retina) or a tear (the vitreous jelly rips the retina during the process of posterior vitreous detachment).Every year, about 1 to 2 people per 10 000 develop retinal detachment.Retinal detachment is a medical emergency.The November 25, 2009, issue of JAMA includes an article about eye floaters and flashes and distinguishing symptoms of retinal detachment.
Association of NaF PET/CT findings with PSA and alkaline phosphatase in untreated castration-sensitive prostate cancer.
Authors: Anna Couvillon, Baris Turkbey, Maria Liza Lindenberg, Peter L. Choyke, Aradhana Kaushal, Deborah E. Citrin, Andra V. Krauze, Deborah McNally, Yolanda McKinney, Mirna Martinez, Hui Han, Fatima Karzai, Howard L. Parnes, Peter A. Pinto, James L. Gulley, William L. Dahut, Ravi Amrit Madan
Journal: Journal of Clinical Oncology (2015)

e16118 Background: NaF PET/CT is an emerging imaging technique with potentially high sensitivity in detecting bone metastasis (mets), however, its role in castration-sensitive prostate cancer (CSPC) is undefined and it remains unclear which CSPC patients should have NaF PET/CT. Methods: We retrospectively reviewed NaF PET/CT scans done on 45 patients with untreated, high risk CSPC with the goal of determining which disease features were associated with positive findings. Two blinded radiologists reviewed each scan and determined by consensus if findings were negative for metastasis (0% liklihood of mets), possible (50%), probable (75%), or consistent with mets (90%). Prostate specific antigen (PSA) and alkaline phosphatase (AP) values were then evaluated at time of NaF scan when available. Results: Of the 45 patients (pts) 2 were Gleason 6, 5 were Gleason 7, 36 were Gleason 8-10, 2 unknown. When grouped by findings on NaF PET/CT, there were no substantial differences seen between median PSA or AP values. When pts with both PSA and AP values > median were evaluated, there was no clear association with NaF PET/CT findings. Conclusions: Preliminary findings from this small retrospective analysis suggest that there may be limited associations between PSA and/or AP with findings on NaF PET/CT scan in untreated patients with CSPC. Further analysis in larger cohorts of pts is required. Median PSA (range) Median AP (range) [normal range 37-116] Number of Pts with PSA and AP both > median All Pts (n = 45) 21 (n = 45; 0.1-236) 66 (n = 38; 38-135) 11 Negative NaF (n = 13) 19.7 (0.21-236) 60 (n = 9; 42-94) 3 Possible Mets on NaF (n=11) 27.1 (1.47-177) 64.5 (n = 10; 53-98) 2 Probable (n = 2) and Consistent with Mets on NaF (n = 19) 17.2 (0.1-123) 69.5 (n = 19; 38-135) 6
Systemic lupus erythematosus in a multiethnic cohort: LUMINA XXXV. Predictive factors of high disease activity over time
Authors: G S Alarcon, J Calvo-Alen, G McGwin, A G Uribe, S M A Toloza, J M Roseman, M Fernandez, B J Fessler, L M Vila, C Ahn, F K Tan, J D Reveille
Journal: Annals of the Rheumatic Diseases (2006)

<b>Aim:</b> To ascertain the predictive factors of high levels of disease activity in systemic lupus erythematosus (SLE). <b>Patients and methods:</b> Patients with SLE (American College of Radiology criteria), aged ⩾16 years, with disease duration ⩽5 years and of Hispanic (Texas and Puerto Rico), African American and Caucasian ethnicities, were included. The outcome was high disease activity at any time (Systemic Lupus Activity Measure—Revised &gt;10). A basic multivariable model (including age, sex, ethnicity, health insurance, social support, abnormal illness-related behaviours, helplessness and prior disease activity) was first examined. Additional models were built by including other variables. <b>Results:</b> 554 patients (100 Hispanics from Texas, 94 Hispanics from Puerto Rico, 199 African Americans, 161 Caucasians) and 2366 visits were analysed; 47% of the patients and 29% of the visits met the definition of high disease activity (more common among African Americans (72.0%) and Hispanics from Texas (71.3%) than among Caucasians (43.9%) and Hispanics from Puerto Rico (31.9%)). Variables found to predict high levels of disease activity were Hispanic (from Texas) and African American ethnicities, lack of health insurance, helplessness, abnormal illness-related behaviours and poor social support; age was negatively associated with high levels of disease activity. African admixture and anti-double-stranded DNA antibodies also predicted high levels of disease activity, as did prior disease activity. None of the human leucocyte antigen variables were retained in the models. <b>Conclusions:</b> Socioeconomic–demographic (age, ethnicity, health insurance), behavioural and psychological variables are important mediators of high levels of disease activity in SLE during its course. Interventions aimed at modifiable factors may improve the outcomes of SLE.
Vital Statistics Table
Journal: BMJ (1964)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Vital Statistics Table Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
AUTHORS' REPLY
Authors: T Norboo, N Bruce, K. Ball
Journal: Thorax (1991)

sweeping, in the enclosed atmosphere ofa hut and tent.These activities have been considered to be responsible for the fact that desert lung is predominantly a disease of women.2"It would be interesting to know whether the woman farmer with massive fibrosis in the paper by Dr Norboo and others had performed any of these traditional chores.Furthermore, being a farmer, had she engaged in ploughing, or earth or well dig- ging, occupations which generate considerable dust exposure during the dry season?Are we truly dealing with progressive massive fibrosis of purely environmental origin?
Manuel d'urétroscopie postérieure.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stevens-Johnson syndrome associated with long-acting sulfonamides
Authors: O. M. Carroll
Journal: JAMA (1966)

THE STEVENS-JOHNSON syndrome (erythema multiforme exudativum; Behçet syndrome)<sup>1</sup>appears to be causally related to the use of the long-acting sulfonamides as well as other drugs and certain disease conditions.<sup>2,3</sup>In an attempt to clarify this association and to delineate the scope of the problem, the Bureau of Medicine of the Food and Drug Administration has surveyed reports from the medical literature, reviewed adverse drug reaction data from other sources in the files of the FDA, and consulted various experts in the field. This communication is a summary of the data obtained and outlines FDA actions on the long-acting sulfonamides. <h3>Background Considerations</h3> The first long-acting sulfonamide was introduced to American medicine in 1957. At the present time, sulfamethoxypyridazine and sulfadimethoxine are in wide clinical use. These drugs require as little as one oral dose every 24 hours to maintain adequate therapeutic levels, thus differing markedly from the short-acting congeners.
Table of Contents
Authors: Harmonj Eyre, Ted Gansler, Arthur Holleb, Thomas Rosenthal, Suzanne Crauiford, Lvite Egan, Ted Gansl, Emily Pualwan, Esmeralda Galan, Rosen Library, Feff Clemenu, Dileep Bal, Robert Young, John Sdfrin, Richard Nder, Lawrence Garfinkel, John Stevens, Gerald Woolam, John Baity, John Seffrin, Frank Cox, Martha Mcgarity, Lippincott Williams, Ray Thibodeau, Nina Clayton, Kim Katz, Barbara Nakahara, Peter Castro, Yesenia Maldonado, Serena Stockwell, Vickie Thaw, Deborah Holmes
Journal: CA A Cancer Journal for Clinicians (2001)
PTU-076 Diagnostic Potential of Volatile Organic Compounds as Faecal Biomarkers in Inflammatory Bowel Disease
Authors: H Jayasena, T Khalid, C S Probert
Journal: Gut (2013)

<h3>Introduction</h3> VOCs can be utilised as non invasive biomarkers for gastrointestinal diseases such as IBD, as changes in VOCs reflect internal metabolical and pathological processes. <h3>Methods</h3> Patients were recruited from outpatients with proven Crohn’s disease(CD N = 41), ulcerative colitis(UC N = 49), IBS(N = 30) and healthy volunteers(N = 47). Disease activity was recorded using Harvey-Bradshaw index(HBI) in CD and simple clinical colitis activity index(SCCAI) in UC. Faecal headspace gas was sampled with SPME and transferred to GC-MS for VOC identification. Statistical analysis was performed on presence or absence and peak area of VOCs. <h3>Results</h3> <b>Conclusion</b>Faecal VOCs are capable of distinguishing IBD from non-inflammatory conditions like IBS and healthy. <h3>Disclosure of Interest</h3> None Declared