tbuckley/cabot-search huggingface dataset:
Mechanisms of Thrombotic Thrombocytopenic Purpura (TTP), a Complication Associated with the Drug Ticlopidine
Journal: Annals of Internal Medicine (2000)

Summaries for Patients16 May 2000Mechanisms of Thrombotic Thrombocytopenic Purpura (TTP), a Complication Associated with the Drug TiclopidineSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-10-200005160-00039 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Ticlopidine is a drug that acts on platelets, the tiny cells in the bloodstream that help blood to clot. Ticlopidine is therefore sometimes used to reduce the risk for strokes by preventing clotting in patients whose arteries leading to the brain are greatly narrowed. It is also used to prevent clots from blocking cardiac stents (tunnel-like devices that are sometimes used to open narrowed blood vessels in the heart), thus cutting down the risk of heart attacks. Thrombotic thrombocytopenic purpura (TTP) is a medical condition that can occur ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Antibody Inhibitors to von Willebrand Factor Metalloproteinase and Increased Binding of von Willebrand Factor to Platelets in Ticlopidine-Associated Thrombotic Thrombocytopenic Purpura.” It is in the 16 May 2000 issue of Annals of Internal Medicine (volume 132, pages 794-799). The authors are H.-M. Tsai, L. Rice, R. Sarode, T.W. Chow, and J.L. Moake.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAntibody Inhibitors to von Willebrand Factor Metalloproteinase and Increased Binding of von Willebrand Factor to Platelets in Ticlopidine-Associated Thrombotic Thrombocytopenic Purpura Han-Mou Tsai , Lawrence Rice , Ravindra Sarode , Thomas W. Chow , and Joel L. Moake Metrics 16 May 2000Volume 132, Issue 10Page: 794KeywordsDrugsKidneysMedical conditionsMetalloproteasesMyocardial infarctionPlateletsStent implantationStrokeThrombosisThrombotic thrombocytopenic purpura Issue Published: 16 May 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
Medical Education and Financial Assistance Programs Sponsored by US Government Agencies
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increasing minority group enrollment. A task force proposal
Authors: B. W. Nelson
Journal: JAMA (1971)

One year ago, in its "Report to the Inter-Association Committee on Expanding Educational Opportunities in Medicine for Blacks and Other Minority Students," an Association of American Medical Colleges (AAMC) Task Force concluded that the main barrier to attending medical school for minority students is the inadequacy of financial aid. Coincident with increasing enrollment of minority students in medical schools, federal and other sources of funds have been decreasing. The need is urgent for reversing this trend and establishing better mechanisms for utilizing available funds. Dr. Cooper reviewed the progress that has been made in the past two years to increase the representation of minority groups in US medical schools.<sup>1</sup>He also reviewed the recommendations of the Task Force for increased financial support of minority group students. As background, several comments regarding present sources of financial assistance for MD candidates in US medical schools are in order. Until recently, the
Hepatic and Metabolic Complications In Adult Patients With Acute Lymphoblastic Leukemia (ALL) Treated With Asparaginase-Containing Combination Chemotherapy: A Single Center Experience
Authors: Jason N. Barreto, Kristen B. McCullough, Candy S Peskey, Louis Letendre, William Hogan, Aref Al-Kali, Mark R. Litzow, Mrinal M. Patnaik
Journal: Blood (2013)
Alterations of Germ Cells Leading to Mutagenesis and Their Detection
Authors: David J. Brusick
Journal: Environmental Health Perspectives (1978)

Germ cell risk is an essential component of estimating the deleterious results of environmental muta- gens.The present set of in vivo model systems appears to have limited ability to measure germ ceOl risk from all types of genetic lesions.The assays most practical for use in genetic testing measure the induction of chromosome alterations but not specific locus gene mutations.Quantitative estimation of germ ceOl risk based on such available assays is diMcult to make and may lead to incorrect assumptions of risk.Better assessment of germ cell genetic damage will require expansion of present procedures to increase sensitivity and the development of improved assay systems.
Is Justification of Animal Research Necessary?
Authors: Tom Regan
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Dr Vance<sup>1</sup>is to be commended for his efforts to demythologize the ALRM. His scholarship and analysis, however, are less than adequate. Two examples will have to suffice. Vance notes that I appeal to what I call "moral intuitions." Among such "intuitions" are the considered beliefs that it is wrong to punish the innocent, to cause gratuitous pain, and to deceive another person merely to gain some advantage for oneself or others. "Moral intuitions" in my view are one way to test moral theories. Given two competing theories, A and B, if B has implications that contradict a large body of our considered moral beliefs, whereas A does not, then we have reason to think that A is a more adequate moral theory than B. Suppose theory A passes this test. Clearly, it would be a mistake to think that the theory itself is intuited. To
ANOTHER GAS HAZARD
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Genome-Wide Analysis of Alternative Splicing in Medulloblastoma Identifies Splicing Patterns Characteristic of Normal Cerebellar Development
Journal: Cancer Research (2011)

In this article (Cancer Res 2011;71:2045–55), which was published in the March 15, 2011 issue of Cancer Research (1), the last sentence of the grant support is incomplete and should read as follows: J. Ham was supported by a Wellcome Trust Senior Research fellowship (grant number 057700) and the work was also funded by a grant from Research in Childhood Cancer.
Patients (pts) with metastatic chromophobe renal cell carcinoma (mchRCC) treated with sunitinib (Su) therapy (tx): Analysis of an international database regarding outcome and comparison to clear cell histology (mccRCC)
Authors: Ibrahim Yildiz, David Sarid, Jae-Lyun Lee, Adi Chish, Avishay Sella, Maya Gottfried, Hans J. Hammers, Mario A. Eisenberger, Michael Anthony Carducci, Victoria J. Sinibaldi, Victoria Neiman, Eli Rosenbaum, Eliahu Gez, Avivit Peer, Wilmosh Mermershtain, Keren Rouvinov, Raanan Berger, Daniel Keizman
Journal: Journal of Clinical Oncology (2015)

e15619 Background: Su is a standard tx for mccRCC. Data on its activity in the rare variant of mchRCC, is limited by very small or heterogeneous (mixed histology with papillary type, or mixed targeted therapies) studies. We analyzed the activity of Su in a relatively large and homogenous international cohort of mchRCC pts, in terms of outcome and comparison to mccRCC. Methods: Records from mchRCC pts treated with 1st line Su in 9 centers across 4 countries were retrospectively reviewed. Univariate and multivariate analyses of association between clinicopathologic factors and outcome were performed. Subsequently, mchRCC pts were individually matched to mccRCC pts. We compared the response rate (RR), progression free survival (PFS), and overall survival (OS) between the groups. Results: Between 2004-2014, 33 pts (median age 64, 45% male) with mchRCC were treated with Su as 1st line tx. 76% had a prior nephrectomy. HENG risk was good 27%, intermediate 55%, and poor 18%. 33% were active smokers, and 30% users of angiotensin system inhibitors (ASIs). 55%, 27%, and 33% had lung, liver and bone metastases, respectively. 48% had a pre-tx neutrophil to lymphocyte ratio (NLR) > 3. 42% had dose reduction/tx interruption (DR/TI). Su induced hypertension (HTN) occurred in 48%. 75% achieved a clinical benefit (partial response + stable disease), while 25% had disease progression within the first 3 months of tx. Median PFS and OS were 10 and 26 months, respectively. Factors associated with PFS were the HENG risk (HR 3.8, p = 0.025) and pre-tx NLR > 3 (HR 0.6, p = 0.012). Factors associated with OS were the HENG risk (HR 4.27, p = 0.027), liver metastases (HR 4.6, p = 0.029), and pre-treatment NLR < 3 (HR 0.5, p = 0.04). Tx outcome was not significantly different between mchRCC pts and mccRCC pts, who were individually matched by HENG risk, nephrectomy/smoking status, pre-tx NLR, use of ASIs, DR/TI, and Su induced HTN. In mccRCC pts (p value versus mchRCC), 70% achieved a clinical benefit (p = 0.58), and median PFS and OS were 9 (p = 0.7) and 24 (p = 0.6) months, respectively. Conclusions: In mchRCC pts, Su tx may have similar outcome to mccRCC pts.
Public Health.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
First International Symposium on the Endocrine Lung in Health and Disease
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article First International Symposium on the Endocrine Lung in Health and Disease Get access JNCI: Journal of the National Cancer Institute, Volume 68, Issue 3, March 1982, Page 535, https://doi.org/10.1093/jnci/68.3.535-e Published: 01 March 1982
THE VALUE OF DRUGS IN SURGERY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sandpapery Skin
Authors: Julia A. Curtis, Scott R. Florell, Jamie Zussman
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Unilateral asterixis in a dialysis patient
Authors: G. Ericson
Journal: JAMA (1978)

ASTERIXIS is seen with many metabolic disorders, the most common being liver failure, renal failure, hyponatremia, and hypercapnea.<sup>1</sup>In the vast majority of cases, it is bilateral, although unilateral flapping has been occasionally described.<sup>1-4</sup>In these cases the unilateral asterixis appeared to be due to anoxia of the contralateral cerebral hemisphere. We report a case of unilateral rightsided asterixis in a uremic patient who subsequently was found to have severe left carotid artery stenosis. <h3>Report of a Case</h3> A 55-year-old man with a six-month history of fatigue and anorexia and an 18-kg weight loss was admitted to the hospital for hemodialysis. For seven years he had been undergoing treatment for hypertension with hydralazine hydrochloride, furosemide, and methyldopa with only moderate success. He had been admitted to another hospital with renal failure and an initial creatinine level of 18.6 mg/dl. Examination at the time showed a blood pressure of
Potential complications of high-dose epinephrine
Authors: Michael Callaham, Chris W. Barton, Steve Kayser
Journal: JAMA (1991)

<h3>In Reply.</h3> — Fleg raises an interesting point regarding the possibility of decreased catecholamine responsiveness with age. The epinephrine dose used did indeed increase with age, with an<i>r</i>value of .24 (by linear regression,<i>y</i>= 1.28×10<sup>-4</sup>-2.39×10<sup>-3</sup>;<i>P</i>=.001) (Figure). There was a similar relationship between age and creatine kinase-MB level, as well as incidence of myocardial infarction. However, we do not believe that any current data justify a dose based on age, particularly considering how poorly studied the dose-response relationship is, and that similar 200-μg/kg doses have been reported to be effective in children when standard doses were not.<sup>1</sup> Karch addresses a wide variety of concerns; we can comment on several. We excluded cardiac arrests due to drug ingestion, and, otherwise, our population resembled all cardiac arrest populations in that the clinician did not and could not know the exact pathophysiological nature of the arrest. Data
Leaving Residency Soon? The AMA Can Help
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Antiviviseetionists.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cushing's Syndrome Associated with Bronchogenic Carcinoma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL EDUCATION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal