tbuckley/cabot-search huggingface dataset:
Handbuch der inneren Sekretion. Eine umfassende Darstellung der Anatomie, Physiologie und Pathologie der endokrinen Drüsen.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment Strategies for Prostate Cancer-Reply
Authors: Grace L. Lu-Yao
Journal: JAMA (1993)

<h3>In Reply.</h3> —The incidence of cancer of the prostate has been increasing in the past 20 years, primarily due to increased detection.<sup>1,2</sup>However, it remains uncertain whether mass screening and the cascade of intervention that follows leads to improved survival. Although there is an apparent increase in survival among diagnosed cases, this is easily explained on the basis of lead- or length-time bias. We appreciate Dr Cockett's viewpoint that younger patients are more likely to benefit from screening and treatment for prostate cancer, but this would hold only if some cancers were curable by treatment. Outcomes researchers simply do not know if this is so and it will take years to find out. Clinical trials comparing radiation, surgery, and watchful waiting are desperately needed and should have been undertaken years ago. The costs of ignorance in terms of pain and dollars are too great. Almost 100 years ago, Dr
TRANSACTIONS AND JOURNALS WANTED.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship of hearing impairment to dementia and cognitive dysfunction in older adults
Authors: R. F. Uhlmann
Journal: JAMA (1989)

We conducted a case-control study in 100 cases who had Alzheimer's-type dementia and 100 age-, sex-, and education-matched, nondemented controls to evaluate the hypothesis that hearing impairment contributes to cognitive dysfunction in older adults. The prevalence of a hearing loss of 30 dB or greater was significantly higher in cases than in controls (odds ratio, 2.0; 95% confidence interval, 1.2 to 3.4), even when adjusted for potentially confounding variables. In addition, we observed a dose-response relationship in which greater hearing loss was associated with a higher adjusted relative odds of having dementia. Hearing loss was also significantly and independently correlated with the severity of cognitive dysfunction, as measured by the Mini-Mental State Examination, in nondemented as well as demented patients. These results demonstrate an association between hearing impairment and dementia and lend support to the hypothesis that hearing impairment contributes to cognitive dysfunction in older adults. (<i>JAMA</i>. 1989;261:1916-1919)
Frequency and Spectrum of Mutations at Codons 12 and 13 of the C-K-ras Gene in Human Tumors
Authors: Gabriel Capella, Sandra Cronauer-Mitra, Miguel Angel Peinado, Manuel Perucho
Journal: Environmental Health Perspectives (1991)

The frequency of point mutations at codons 12 and 13 of the c-K-ras gene has been determined in a panel of more than 400 human tumors. Mutant c-K-ras genes were detected in about 75% of adenocarcinomas of the pancreas (n = 84); 40% of adenomas (n = 72) and carcinomas (n = 244) of the colon end rectum; 30% of carcinomas of the bile duct (n = 19); 25% of carcinomas of the lung (n = 92), and in lower frequency in other carcinomas, including liver, stomach, and kidney. No mutations were found in carcinomas of the breast, prostate, esophagus, and gall bladder, among others. Comparative analysis of the spectrum of mutations show that while G to A transitions were the most frequent mutations in pancreatic and colo-rectal tumors, G to T transversions were more prevalent in lung carcinomas. The aspartic acid mutation at codon 13 (GGC----GAC) was relatively frequent in colo-rectal tumors but rare in pancreatic and lung carcinomas. The differences in the mutation spectrum of the c-K-ras gene in cancers of the gastrointestinal and respiratory tracts are suggestive of differential exposure to genotoxic agents.
The Autopsy: Obtaining Quality Assurance of Treatment
Authors: M. Shahriar Salamat
Journal: Neuro-Oncology (2001)

While we hope that one day all of our patients with CNS tumors will be cured, we must not lose sight that still much is to be learned about these tumors and their therapies.In this respect, the ultimate method of quality assurance, the autopsy, should not be forgotten.Regrettably, in recent years, there seems to have been an inverse relation between multiple methods of imaging, biopsying and resecting, classifying and grading, and treating CNS tumors and the percentage of tumor patients who end up having an autopsy.For most of us, experience in postmortem evaluation of treated CNS tumors can only be summarized in anecdotal recounts, rather than through experience with this additional scientific approach that can determine the effects of therapies that we provide.A real understanding of tumor response to therapy is achieved only if we all make a
Effect of interferon alpha the TNF-? production by peripheral blood monocytes during chronic hepatitis C 1. 1CJF INSERM 91-07, 2Service d'H�pato-Gastroent�rologie, 3Service de M�decine Interne, Toulouse, France
Journal: Hepatology (1995)

Objective. Because recruitment and retention of lymphoid cells appear to be critical components of the pathogenesis of lichen planus, we have compared the expression and distribution of a panel of vascular adhesion molecules (ELAM-1, P-selectin, 1CAM-1, VCAM-1, PECAM-1, CD34) and leukocyte adhesion molecule ligands (LFA-1, Mac-1, VLA4, L-selectin) in biopsies of this disease.Study design. Frozen sections of 12 clinically and histologically confirmed cases of lichen planus and 9 normal control tissues were evaluated immunohistochemically with a standard 1-day avidin-biotin peroxidase technique. Staining intensity of vascular endothelium was evaluated semiquentitatively. Three microvascular zones or compartments were defined and evaluated separately.Results. Generally, different staining patterns were observed in association with the various endothelium-associated adhesion molecules. In normal controls, PECAM was intensely expressed, and VCAM-1 was weakly expressed. Intermediate staining was associated with ELAM-1, P-selectin, ICAM-1, and CD34. Staining within the three microvascular compartments frequently showed variations in intensity. In lichen planus, increased staining for ELAM-1, P-selectin, ICAM-1, and VCAM-1 was evident in one or more of the microvascular compartments. In the subepithelial vascular compartment where the infiltrate was the most dense, VCAM-1 appeared to show the greatest positive change. Almost all cells in the lichen planus infiltrates stained positive for 1CAM-1, L-selectin, LFA-1, and VLA4, and large numbers of cells also exhibited VCAM-1, PECAM-1, and Mac-1 immunoreactivity.Conclusions. It appears that upregulation of ELAM-1, ICAM-1, and VCAM-1 (especially by endothelial cells in the subepithelial vascular plexus) could play a role in the pathogenesis of lichen planus. The expression of leukocyte receptors L-selectin, LFA-1, and VLA4 by most of the cells in the lichen planus infiltrate suggest that these molecules may be responsible for recruitment as well as retention in the active lichen planus lesion.
Pyoderma in Children
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinically suspected deep venous thrombosis of the lower extremities. A comparison of venography, impedance plethysmography, and radiolabeled fibrinogen
Authors: K. M. Moser
Journal: JAMA (1977)

To define the utility of new diagnostic approaches in patients with clinically suspected deep venous thrombosis of the lower extremities, 42 legs of 33 patients were studied by fibrinogen labeled with radioactive iodine (<sup>125</sup>I) impedance plethysmography (IPG), and contrast venography. The clinical diagnosis was confirmed in approximately two thirds of the legs and patients. In venogram-positive legs, fibrinogen<sup>125</sup>I was positive in 70%, IPG in 61%, and one of the two in 78%. In venogram-negative legs, fibrinogen<sup>125</sup>I was positive in four (21%) and IPG was negative in all. It was found that the size, age, and location of the thrombus, collateral vein development, heparin sodium therapy, and technical-interpretive choices can influence both IPG and fibrinogen<sup>125</sup>I results. The data demonstrate that the fibrinogen<sup>125</sup>I and IPG procedures can assist physicians in the diagnosis of clinically suspected deep venous thrombosis of the lower extremities. (<i>JAMA</i>237:2195-2198, 1977)
HYPERTENSION WITH MINIMAL RENAL LESIONS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notes on Military Hygiene for Officers of the Line.—A Syllabus of Lectures formerly delivered at the United States Infantry and Cavalry School
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re: A Randomized, Placebo-Controlled Trial of Zoledronic Acid in Patients With Hormone-Refractory Metastatic Prostate Carcinoma
Authors: A. Berruti, M. Tucci, C. Terrone, R. M. Scarpa, A. Angeli, L. Dogliotti
Journal: JNCI Journal of the National Cancer Institute (2003)
" CANCER HOUSES " AND CANCER AREAS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some Practical Aspects of Cancer Prevention
Authors: Ernest L. Wynder
Journal: New England Journal of Medicine (1952)

Carcinoma of the Oral Cavity Incidence In 1948, cancer of the buccal cavity and pharynx accounted for 4558 male and 1154 female deaths in the United States, representing 4.7 per cent of all male and 1.2 per cent of all female cancer deaths.21 A high incidence of oral cancer occurs in India.65 Among 6077 patients at the Tata Memorial Hospital with neoplastic disease, 2179 had oral cancers. The primary sites included: base of tongue, 40.7 per cent; buccal mucosa, 18.5 per cent; tonsil, 15.1 per cent; anterior part of tongue, 13.6 per cent; palate, 5.3 per cent; alveolar ridge, 3.6 . . .
General Internal Medicine
Authors: John D. Stoeckle
Journal: JAMA (1992)

With the medical profession facing challenges today in the organization, financing, and focus of health care, general internal medicine has examined related issues in clinical research, practice organization, and training. Research studies both in and of practice have addressed modern missions of this specialty, namely (1) to promote prevention in practice populations, (2) to improve care to optimize functional health outcomes, and (3) to expand patient participation in decision making. Prevention in practice populations has new importance and direction. It substitutes, in part, for community-based public health programs that have lost their traditional governmental support; it promises to reduce the burden of chronic disease, applying epidemiologic research and early treatment; it complements the current emphasis on the hospital care of the very sick; and it gains more professional acceptance as the basic science molecular biology can now explain how preventive interventions may act.<sup>1</sup>The renewed directions and tasks-<i>health</i>
Unusual course of infectious mononucleosis
Authors: J. Zahavi
Journal: JAMA (1967)

INFECTIOUS mononucleosis is a disease with protean symptomatology, varied, atypical, and complicated in its course; the signs and symptoms may not be suggestive and the diagnosis is sometimes reached only incidentally and late. We herewith present a case with such an unusual sequence of events. <h3>Report of a Case</h3> A 63-year-old man was admitted to surgical department C on May 25, 1965, because of pain in the left lower quadrant of the abdomen, of three days' duration, accompanied by nausea and constipation. In 1926, a left nephrectomy had been performed because of nephrolithiasis with nonfunctioning kidney. Since 1937 he had been suffering from epigastric pain attributed to hypertrophic gastritis; since 1953, from intermittent claudication of both legs; and since May 1964, from attacks of precordial pain lasting five to ten minutes; serial electrocardiograms, however, were normal. Blood pressure readings of 200/100 to 110 mm Hg were found on many occasions.
News
Authors: T Delamothe
Journal: BMJ (1989)

Taking money from the devil in Victoria Just over a year ago the Australian state of Victoria introduced the sort of antismoking legislation that is becoming commonplace elsewhere: out went cigarette advertising on billboards and in the cinema, the production and sale of smokeless tobacco, and lenient laws prohibiting the sale of tobacco to minors.The Xictorian Tobacco Bill differed, how- ever, by introducing a "tobacco tax" of 11 cents on each packet of cigarettes.In 1988 the levy yielded about $A23m (or £10m-£2.50 per head of population), paid directly
先天性黑色素细胞痣的激光疗法:系统性评述
Authors: C.A.M. Eggen, J.E. Lommerts, E.J. van Zuuren, J. Limpens, S.G.M.A. Pasmans, A. Wolkerstorfer
Journal: British Journal of Dermatology (2018)

大多数人的皮肤上都有几个褐斑,我们称之为黑色素细胞痣或痣。痣对人体无害,但偶尔可能转化为潜在致死性肿瘤,也就是恶性黑色素瘤。先天性黑色素细胞痣(CMN)在婴儿出生时就存在,或者在出生后第一周逐渐形成。先天性痣,尤其是尺寸较大并长于明显部位的痣对于那些对自己的容貌不满意的人来说是个巨大的负担。此外,拥有CMN(尤其是较大的CMN)的患者患上恶性黑色素瘤的风险也会增加。拥有CMN的患者罹患恶性黑色素瘤的风险被认为在0.7%至2.9%之间。通过手术摘除CMN以降低黑色素瘤的风险是一种常见的疗法,但尚未有证据能够证明这种疗法能够降低黑色素瘤的风险。CMN可能过大因而无法完全切除,而且切除手术可能会引起瘢痕。因此近年来,科学家们探索了其他的治疗方法,包括使用激光来消除CMN。这种做法存在争议,主要是因为缺乏证据证明其功效,以及安全性方面的考虑。一些人表示,激光可以通过减少黑色素块来降低恶性肿瘤的风险,而另一些人则担心激光损伤可能会引发潜在癌症。这项在荷兰开展的研究旨在评述用于消除CMN所采用的不同类型的激光的功效和安全性。研究人员发现,医院使用着大量的激光设备和激光组合来治疗先天性痣。一些低质量证据证明CMN的激光治疗在短期内有效且安全,但发生瘢痕、色素再生(色素又重现)和并发症的几率较高。我们需要进行更多高质量的研究,以切实回答有关CMN的激光治疗的功效和安全性问题。
Assessing basophil activation by flow cytometry and mass cytometry in blood stored 24 hours before analysis
Authors: Kaori Mukai, Nicolas Gaudenzio, Sheena Gupta, Nora Vivanco, Sean C. Bendall, Holden T. Maecker, R. Sharon Chinthrajah, Mindy Tsai, Kari C. Nadeau, Stephen J. Galli
Journal: Journal of Allergy and Clinical Immunology (2017)
Ischemic Proctitis
Authors: Zachary M. Kilpatrick
Journal: JAMA (1968)

Vascular disease may lead to ischemic damage to the colon which hiterto has been thought to be confined to the proximal and descending colon and to spare the distal sigmoid and rectum. Studies here report a syndrome clinically, roentgenographically, and histologically recognizable as spontaneous ischemic disease of the rectum. In older persons, abdominal pain, alteration of bowel function, and rectal bleeding together with (1) the sigmoidoscopic appearance of bizarre nodular polypoid or ulcerative changes and (2) roentgenographic evidence of mucosal edema and ulceration with "thumb prints" characterize this syndrome and should raise the possibility of vascular injury to the lower bowel.
The Journal of Experimental Medicine.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal