tbuckley/cabot-search huggingface dataset:
Long term risk of invasive cancer after treatment for cervical intraepithelial neoplasia grade 3: population based cohort study
Journal: BMJ (2008)

Objective To study the long term risk of invasive cancer of the cervix or vagina after treatment for cervical intraepithelial neoplasia grade 3. Design Prospective cohort study.Setting Swedish cancer registry.Participants All women in Sweden with severe dysplasia or cervical carcinoma in situ (equivalent to cervical intraepithelial neoplasia grade 3) treated during 1958-2002 (n=132 493) contributing 2 315 724 woman years.Main outcome measures Standardised incidence ratios with risk of cancer in the Swedish general female population as reference, and relative risks in multivariable log-linear regression model, with internal references.Results Women with previous cervical intraepithelial neoplasia grade 3 had an increased risk of invasive cervical cancer compared with the general female population (standardised incidence ratio 2.34, 95% confidence interval 2.18 to 2.50).The increased risk showed a decreasing trend with time since diagnosis for women treated later than 1970 but the risk was still increased after 25 years.An effect of age was found, with an accentuated increase in risk for women aged more than 50.The excess risk for cervical cancer associated with previous cervical intraepithelial neoplasia grade 3 has steadily increased since 1958.For vaginal cancer the standardised incidence ratio was 6.82 (5.61 to 8.21) but this decreased to 2.65 after 25 years.Adjustments in the multivariable log-linear regression model did not substantially alter these results.Conclusions Women previously treated for cervical intraepithelial neoplasia grade 3 are at an increased risk of developing invasive cervical cancer and vaginal cancer.This risk has increased since the 1960s and is accentuated in women aged more than 50.The risk is still increased 25 years after treatment.
Abnormal abdominal gas shadows in a diabetic baby
Authors: J. Bar-Ziv
Journal: JAMA (1979)

<h3>History</h3> A 4 1/2-month-old child was hospitalized from birth because of neonatal diabetes mellitus. Great difficulty in stabilizing and controlling the diabetes was experienced throughout the hospital stay. A profuse watery diarrhea developed. The child's condition rapidly deteriorated, and the baby died ten days later. Terminally the infant had hematemesis. Physical examination showed a moribund febrile baby with clinical evidence of sepsis. Figures 1 and 2 are posteroanterior and lateral roentgenograms obtained several days before death to verify the presence of pneumonia. <h3>Diagnosis</h3> Necrotizing enterocolitis. Figures 1 and 2 confirmed the presence of basal lobular pneumonia on the right. Gas in the hepatic blood vessels is apparent on both views. The presence of mottled air lucencies is also noted in the region of the spleen. The diagnosis was verified at autopsy. A pneumoperitoneum and patchy necrosis of the bowel were present. There was air in the mesentery of the bowel,
Radiologic Diagnosis
Authors: H. C. Ho
Journal: JAMA (1972)

The majority of malignant tumors occurring in the nasopharynx are carcinomas usually of the epidermoid type, either undifferentiated or of varying degree of differentiation. Lymphoepithelioma is now accepted by most authorities as a poorly differentiated variant of epidermoid carcinoma. The diagnosis of nasopharyngeal carcinoma is often made after a long delay when the disease has already become advanced. This is largely because nasopharyngoscopy is a difficult procedure except in the hands of the expert. It is not possible to perform this procedure in the presence of trismus (not a rare complication resulting from the lateral spread of the carcinoma to the pterygoid muscles), or when there is a hyperactive pharyngeal reflex, in which case general anesthesia is required. Therefore, if a method which offers simplicity of execution and an acceptable degree of reliability in demonstrating nasopharyngeal lesions could be found, it would go a long way to minimize the diagnostic
Keeping Up With the Literature
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Oncology
Authors: Jacob D. Bitran
Journal: JAMA (1996)

At latest count there are five major textbooks of clinical oncology and cancer medicine. The newest addition is<i>Clinical Oncology</i>, edited by Drs Abeloff, Armitage, Lichter, and Niederhuber. In reviewing<i>Clinical Oncology</i>, my intent is not to compare this text with the others, but rather to discuss its unique strengths and weaknesses. The editors recognized that this text would need to serve a diverse readership and provide comprehensive information in a usable format. They are to be congratulated in achieving these aims.<i>Clinical Oncology</i>is exceedingly well written, well organized, easy to read, and usable. <i>Clinical Oncology</i>is divided into four parts: "Science of Oncology," "Problems Common to Cancer and Its Therapy," "Management of Specific Malignancies," and "Rehabilitation of the Cancer Patient." Part 1 has more than 350 pages devoted to the cellular and molecular biology of the cancer cell, the etiologic causes of cancer, principles of diagnosis and therapy,
Fifteenth Annual Malignant Disease Symposium
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article Fifteenth Annual Malignant Disease Symposium Get access JNCI: Journal of the National Cancer Institute, Volume 69, Issue 2, August 1982, Page 547, https://doi.org/10.1093/jnci/69.2.547-c Published: 01 August 1982
Pott's disease in heroin addicts
Authors: S. W. Forlenza
Journal: JAMA (1979)

Five cases of tuberculous vertebral osteomyelitis occurred in heroin addicts at St Luke's Hospital Center between 1955 and 1975. All patients were men, and four were between 19 and 33 years of age. In contrast with the indolent onset typical to pyogenic or fungal vertebral osteomyelitis in heroin addicts, patients with Pott's disease had an acute toxic reaction, with fever, back pain, weight loss, and night sweats. Neurological abnormalities, uncommon with pyogenic or fungal vertebral infection, occurred in all patients with tuberculous involvement of the spine. Roentgenograms of the spine were atypical in four patients, including two with an "ivory vertebra." All patients had involvement of extravertebral sites, and one patient had infection with<i>Mycobacterium tuberculosis and M avium</i>. (<i>JAMA</i>241:379-380, 1979)
Size and number of examined lymph nodes impacts outcome in patients with stage II colorectal cancer
Authors: L. Chirieac, Y. Suehiro, A. Niemisto, I. Shmulevich, S. Lunagomez, J. Morris, S. R. Hamilton
Journal: Journal of Clinical Oncology (2004)

3507 Background: Published analyses concluded that pathologic assessment of lymph nodes in colorectal cancer surgical specimens is often suboptimal and that examining greater numbers of nodes increases the likelihood of proper staging of stage II tumors. The number of lymph nodes may reflect surgical technique and thoroughness of pathologic dissection. We postulated that size in addition to number of nodes can impact survival. Methods: We evaluated 129 consecutive patients with available pathologic materials of stage II adenocarcinoma of the colon and rectum treated with surgery alone at The University of Texas M. D. Anderson Cancer Center between 1990 and 1998. All H&E sections were reviewed retrospectively without knowledge of patient follow-up status. All glass slides with lymph nodes were then digitally scanned and the surface area of the nodes recorded. Various clinicopathologic features, including number and size of lymph nodes (mean, median, sum, maximum), and demographic data were compared with outcome by survival analysis with log-rank tests. Results: The mean number of lymph nodes examined was 12.5 (95% confidence interval 10.9–14.0, range 0–51). As in previous reports, a larger number of examined lymph nodes was associated with better overall survival: mean survival was 128 ± 6 (standard error) months for patients with more than the median number of lymph nodes as contrasted with 106 ± 8 months (p=.007). In addition, the mean overall survival of patients with larger lymph nodes was longer: 123 ± 6 months vs. 106 ± 8 months (p=.03). The sum of the sizes of the nodes and the maximum size were significant predictors for survival (p=.009 and .007, respectively). Overall survival was best in patients with large numbers of large nodes and worst in those with small numbers of small nodes. Additional analyses are in progress. Conclusions: The size as well as the number of lymph nodes examined in resection specimens influences overall survival in patients with stage II adenocarcinoma of the colorectum treated with surgery alone. We speculate that large numbers of large lymph nodes are due to host response to the cancer that contributes to improved survival. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Genentech
Abstract 3616: Left Atrial Size Association with Incident Ischemic Stroke and All-Cause Mortality in African Americans: the Atherosclerosis Risks in Communities (ARIC) Study
Authors: Harsha S Nagarajarao, Alan D Penman, Herman A Taylor, Thomas Mosley, Kenneth Butler, Thomas N Skelton, Tandaw Samdarshi, Ervin R Fox
Journal: Circulation (2007)

Background: The association between left atrial (LA) size, ischemic stroke and mortality has been investigated in non-Hispanic whites but not in African Americans despite their disproportionately higher rates of stroke and cardiovascular mortality. Purpose: We examined the association of LA size assessed by echocardiogram with the incidence of ischemic stroke and all-cause mortality in a large population-based cohort of African Americans. Methods: Participants in the Jackson cohort of the ARIC study have been extensively evaluated including echocardiograms during the third examination (1993–1995) and have been followed for incident cardiovascular events including stroke. Results: The study population consisted of 1,887 participants of which 660 (35%) were men with a mean age of 58.9 ± 5.7 years. LA diameter by tertile was significantly related to hypertension, diabetes and body mass index (BMI) (p&lt;0.0001 for each). Over a median follow-up period of 8.8 years, there were 103 incident strokes (6.47 per 1,000 person-years) and 206 deaths (13.3 per 1,000 person-years). Adjusting for age, sex, hypertension, smoking, diabetes, total cholesterol:HDL ratio, and BMI, LA size was associated with stroke (HR per 10 mm increment of LA diameter 1.44; 95% CI: 0.99, 2.08, p = 0.05) and significantly associated with mortality (HR 1.38; 95% CI: 1.06,1.79 p &lt; 0.02). After further adjustment for prevalent CHD and congestive heart failure, only the association with mortality remained statistically significant (p &lt; 0.03). Conclusions: In this middle-aged population based cohort of African Americans, LA size was significantly associated with all-cause mortality independent of traditional cardiovascular risk factors.
ERRATUM
Journal: Journal of Clinical Oncology (2008)

contained errors due to the inaccurate calculation of underlying expected rates from the data management company.In the third paragraph, the overall standardized mortality ratio (SMR) was given as 11 (95% CI, 7.8 to 15.3), whereas it should have been 1.10 (95% CI, 0.77 to 1.53).SMRs for less than 1 year, 1 to 4 years, 5 to 9 years, and 10 or more years after initial diagnosis were given as 11.7, 5.9, 13.8 and 11.7 respectively, whereas it should have been 1.17, 0.59, 1.38, and 1.17 respectively.SMRs for patients diagnosed at 0 to 4 years of age, 5 to 9 years, 10 to 14 years, and 15 to 20 years were given as 3.26, 8.8, 12.9, and 12.1 respectively, whereas it should have been 0.32, 0.88, 1.28, and 1.20 respectively.The SMR for males was given as 10.9 (95% CI, 7.3 to 15.6), and for females as 11.8 (95% CI, 4.7 to 24.4), whereas it should have been 1.08 (95% CI, 0.73 to 1.56) and 1.18 (95% CI, 0.47 to 2.44) respectively.The SMR for patients diagnosed before 1985 was given as 11.9 (95% CI, 7.8 to 17.5), and for those in subsequent years as 9.2 (95% CI, 4.4 to 17.0), whereas it should have been 1.19 (95% CI, 0.78 to 1.75) and 0.92 (95% CI, 0.44 to 1.70) respectively.The SMR for patients initially treated with radiation was given as 9.8 (95% CI, 5.2 to 16.8), and for those who did not receive radiotherapy as 11.9 (95% CI, 7.5 to 17.8), whereas it should have been 0.98 (95% CI, 0.52 to 1.68) and 1.18 (95% CI, 0.75 to 1.78) respectively.
Angiocardiography as a Diagnostic Aid in Congenital Heart Disease
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"BECLOMETHASONE/FORMOTEROL VERSUS BUDESONIDE/FORMOTEROL COMBINATION THERAPY IN ASTHMA". A. PAPI, P.L. PAGGIARO, G. NICOLINI, A.M. VIGNOLA AND L.M. FABBRI ON BEHALF OF THE INHALED COMBINATION ASTHMA TREATMENT VERSUS SYMBICORT (ICAT SY) STUDY GROUP. EUR RESPIR J 2007; 29: 682-689.
Journal: European Respiratory Journal (2008)
Rashes Among Schoolchildren— 14 States, October 4, 2001–February 27, 2002
Journal: JAMA (2002)

Fourteen states (Arizona, Connecticut, Florida, Georgia, Indiana, Mississippi, New York, Ohio, Oregon, Pennsylvania, Texas, Virginia, Washington, and West Virginia) have reported investigations of multiple schoolchildren who have developed rashes. This report summarizes the investigation by state and local health departments of these rashes, which have occurred during October 2001 through February 2002, and provides examples for four states. Preliminary findings indicate that further investigation is needed to determine whether a common etiology for these rashes exists.
Prostatosis
Authors: David Rosenbloom
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The article was gratifying because of its rational and scientifically grounded differentiation between two distinct prostate diseases. In 1955,I described my concept of "chronic prostatitis," and, to the best of my knowledge, I introduced the distinctive word "prostatosis" to differentiate the noninfective prostate syndrome from true bacterial prostatitis (<i>Calif Med</i>82:454, 1955). My concept was generally accepted as valid, but it did receive some adverse criticism (<i>Calif Med</i>83:98, 1955). Meares and his Stanford group, who have done such excellent investigative work on urinary tract infection, have differentiated bacterial prostatitis from "prostatosis" most lucidly.
Highlights
Journal: JAMA (2015)

Steroids in Acute Radiculopathy Due to a Herniated Disk 1916In a randomized trial that enrolled 269 patients with acute radiculopathy due to a herniated lumbar disk, Goldberg and colleagues assessed the eff ect of a tapering 15-day course of oral prednisone (total cumulative dose, 600 mg) on physical function and pain.The authors report that compared with placebo, short-course oral steroids resulted in modest improvement in function but no improvement in pain.
Retraction Note: Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus
Authors: Agnès Doreau, Alexandre Belot, Jérémy Bastid, Benjamin Riche, Marie-Claude Trescol-Biemont, Bruno Ranchin, Nicole Fabien, Pierre Cochat, Claire Pouteil-Noble, Pierre Trolliet, Isabelle Durieu, Jacques Tebib, Berhouz Kassai, Stéphane Ansieau, Alain Puisieux, Jean-François Eliaou, Nathalie Bonnefoy-Bérard
Journal: Nature Immunology (2014)
Trials test new biologic, old therapeutic concept
Authors: B. Merz
Journal: JAMA (1986)

TUMOR NECROSIS FACTOR (TNF) is the most recent biologic response modifier to reach clinical trials in cancer therapy. Yet it is the direct descendant of one of the earliest attempts to provoke an antitumor immune response. The rationale for therapy with TNF—a protein secreted by macrophages challenged by bacterial endotoxins—dates to the late 1800s, when physicians noticed that cancer patients who had spontaneous tumor regression often also had bacterial infections. In 1893, a New York city physician, William Coley, MD, began to treat cancer patients with a cocktail of bacterial products, which came to be known as Coley's toxins. The patients usually developed high fevers, and, in some, tumors regressed. In 1934, the American Medical Association labeled Coley's toxins as the only known systemic treatment for cancer. But Coley's toxins proved to be less reliable in achieving remissions than did radiation and chemotherapy, and in the 1960s the treatment was
Renal Osteodystrophy
Authors: Harmut H. Malluche, Marie-Claude Faugere
Journal: New England Journal of Medicine (1989)

Replacement of the kidney's excretory function by dialysis has prolonged life, but it has also revealed the extent and importance of the organ's endocrine function. Lacking the kidney's endocrine contributions, patients undergoing long-term maintenance dialysis have considerable morbidity and mortality. Renal osteodystrophy, which is related to the diminished production of 1,25-dihydroxyvitamin D (1,25D), is one abnormality that results from the disturbed endocrine function of failing kidneys. Current research is attempting to unravel the pathogenetic events and underlying mechanisms of uremic osteodystrophy. These include, in addition to the increased excretion of phosphate per nephron and the impaired production of 1,25D, the . . .
Reply
Authors: S.K. Jones
Journal: British Journal of Dermatology (1987)

Journal Article Reply Get access S.K. Jones S.K. Jones Department of Dermatology, Bristol Royal Infirmary, Bristol U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 5, 1 November 1987, Page 672, https://doi.org/10.1111/j.1365-2133.1987.tb07512.x Published: 01 November 1987
Instruction Course Program
Authors: William Tasman, A Berlin, Susan Day, Walter Hartel, Sara Kaltreider, John Mccrary, Carl Migliazzo, David Parke, George Stem, Douglas Koch, Stephen Slane, St Paul, David Dillman, Richard Lindstrom, Mark Greenwald, Howard Gimbe~, F Hampton, Little Rock, Harry Grabow, Susan Stenson, New York, Byron Demorest, Cal Dean, C Brick, Randy Craven
Journal: Ophthalmology (1995)
International Contributions to Medical Literature. "Festschrift" in Honor of Abraham Jacobi, M.D., LL.D. To commemorate the Seventieth Anniversary of His Birth
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation and Validation Issues in the Development of Transgenic Mouse Carcinogenicity Bioassays
Authors: Raymond W. Tennant
Journal: Environmental Health Perspectives (1998)

Transgenic mouse models have emerged as plausible alternatives to long-term bioassays for carcinogenicity.Three transgenic lines evaluated to date have shown a clear capability to discriminate between carcinogens and noncarcinogens, using long-term bioassay results as the standard.The data also suggest that the transgenic lines will not fully duplicate long-term bioassay results.It is proposed that these models do not respond to chemicals that have induced highly restricted species or strain-specific tumor responses in mice or rats.Rather, the value of the transgenic models is predicated on a preferential response to transspecies carcinogens (i.e., those positive in both rats and mice, often including tumors in the same tissues).Thus, although results in transgenic models may not be completely concordant with long-term bioassays, the data can be used effectively in chemical and drug safety assessments.Further, it is proposed that validation of the models is readily achievable via ongoing studies.Validation of any alternative model is best achieved by sufficient mechanistic understanding of the model to reasonably predict the outcome of bioassays conducted in the models and use all available information on the drug or chemical.This goal can now be met with the transgenic mouse lines.
Correction
Journal: BMJ (1963)

very acute painful emergency, such as acute gout resistant to other measures, a " Bren gun " attack may be used, the ordinary preparation of corticotrophin being given, about 10 units one to two-hourly for four injections at the same time as the initial injection of the slower-acting gel preparation is given.This gives more rapid relief than a, single injection of gel and spares the patient the discomfort of an intravenous infusion.