tbuckley/cabot-search huggingface dataset:
Vitiligo and multiple glandular insufficiencies
Authors: B. C. McGregor
Journal: JAMA (1972)

Seven patients had vitiligo associated with pluriglandular insufficiency. There may be a common autoimmune pathogenesis. Vitiligo may be a readily identifiable and early external manifestation, pointing to a possible multiple glandular insufficiency syndrome. Because of the serious nature of the associated glandular deficiencies, and since they appear sequentially, yearly examinations for the associated conditions are probably indicated in the propositus and on blood relatives.
First global conference on medical education
Authors: A. A. Skolnick
Journal: JAMA (1994)

EXTENDING the concerns of medical education beyond the traditional pattern and "onto new terrain of health and social development" was the aim of a first-ever meeting held this summer in Rockford, Ill. At the Global Conference on International Collaboration on Medical Education and Practice, John H. Bryant, MD, a noted medical educator and chair of the Department of Community Health Sciences at The Aga Khan University, Karachi, Pakistan, discussed the interface between medical education and practice and the health care of populations. One of Bryant's theses, which he strongly stated and others reiterated, is that training physicians simply to treat individual patients who present in the office or hospital is not going to get the global health care job done anymore. A broader view, which has gained force in the 16 years since it was set forth, is informed by the ethical principles designating health a basic human right embraced
Re: Regionalization of perinatal services
Authors: H. A. Hein
Journal: JAMA (1985)

<h3>In Reply.—</h3> Sadly, Sterling and Arundel have misquoted my editorial. It did not say that "the results of the Erickson study show that there is no basis for a link between Agent Orange and birth defects." It said, "it is unlikely that serious congenital abnormalities in children of men serving in Vietnam were results of that experience."<sup>1</sup> Of the almost 100 congenital abnormalities investigated in the study, Sterling and Arundel pointed out the two whose incidence was higher than expected. Yet they have failed to mention the four abnormalities whose incidence was less than expected. If one were to adhere to this solely statistical line of reasoning, a valid conclusion would be that children of veterans of this era were somehow protected from hydrocephalus, anophthalmia, liver and gallbladder abnormalities, and sex organ defects.<sup>2</sup> To be valid, differences in expected incidence must not only be statistically unusual, they must
Family physician pathway and medical student career choice. Ten years after curriculum change at the University of Washington
Authors: T. J. Phillips
Journal: JAMA (1978)

In 1968 the University of Washington School of Medicine initiated a new curriculum that included a family physician pathway. Six of these classes have now graduated. Two thirds of the planned strategies for the pathway were actually implemented. Approximately half of the students in each second-year class now choose this pathway. Ninety percent of those graduating have done so in the traditional four years. Seventy-three percent of those in the pathway actually pursued family practice training on graduation. Approximately one third of all University of Washington graduates now enter training for family practice, one third enter internal medicine, 10% enter surgical fields, and 8% enter pediatrics. These rates represent significant increases in the proportion of students entering directly into family practice, internal medicine, and pediatrics training. (<i>JAMA</i>240:1736-1741, 1978)
ERRATUM
Journal: Circulation (1958)

RUBIN, A. L., LUBASH, G. D., COHEN, B. D., BRAILOVSKY, D., BRAVEMAN, W. S., AND LUCKEY, E. H.: Electrocardiographic changes during hemodialysis with the artificial kidney. Circulation: 18: 227-234 (August), 1958. On page 229, figure 3 was inadvertently omitted. The arrangement of figures 2 and 3, with legends, should have appeared as shown to the right.
Treatment without consent: intervention by the court.
Journal: BMJ (1985)

The British Medical Journal's legal correspondent reviews two English court decisions concerning treatment or nontreatment of minors against the wishes of their parents. In the 1981 case In re P, the court sanctioned the abortion request of a 15-year-old ward of the court, whose parents objected to the procedure. In the 1976 decision In re D (A Minor), the court refused to authorize the sterilization of an 11-year-old retarded girl, despite her mother's request and a physician's recommendation. Physicians apprehensive about treating minors in sexual matters in light of the recent Gillick decision concerning contraception without parental consent are advised to contact the local juvenile authority, which can apply to the court for guidance and direction.
Book Reviews
Authors: J. VILCEK
Journal: JNCI Journal of the National Cancer Institute (1989)

Book Reviews Get access Monokines and Other Non-Lymphocytic Cytokines Michael C. Powanada Joost J. Oppenheim Matthew J. Kluger Charlesd A. Dinarello eds. New York: Alan R. Liss, Inc., 1988, 444 pp. $86.00. JAN VILČEK JAN VILČEK Department of Microbiology and Kaplan Cancer CenterNew York University Medical Center 550 First Avenue New York, NY 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 3, 1 February 1989, Page 233, https://doi.org/10.1093/jnci/81.3.233 Published: 01 February 1989
Myocardial infarction and other vascular diseases in young women. Role of estrogens and other factors
Authors: H. Jick
Journal: JAMA (1978)

We studied 83 women younger than 46 years with acute myocardial infarction (MI) and 154 controls. There was a strong positive association between MI and the following: (1) age, (2) both oral contraceptive and noncontraceptive estrogen use, (3) cigarette smoking, and (4) the presence of predisposing medical conditions, eg, past MI, hypertension, and diabetes. ABO blood type and family history of arterial disease were also positively associated with MI. Whereas the risks for idiopathic stroke and venous thromboembolism have also been shown to be increased among oral contraceptive users, there is comparatively little correlation between these two illnesses and age or smoking in young women. The present study, taken together with previously published work, provides reasonable estimates of the vascular risks associated with oral contraceptive use. (<i>JAMA</i>240:2548-2552, 1978)
Traitement médical des affections stomacales.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical television. Prescription for progress
Authors: W. Borow
Journal: JAMA (1993)

VISITORS to the New York World's Fair in 1939 saw an intriguing display at the RCA pavilion. On a tiny black-and-white picture tube, the ghostlike image of David Sarnoff, then chairperson of RCA, spoke to the world, predicting a great future for the new medium of television. A quick glance at the headlines of the day provides some indication of the wonder television generated. As<i>Business Week</i>proclaimed, "Curtain Goes Up on Television," and<i>Collier's</i>promised, "Before Your Very Eyes." More wary,<i>Time</i>deemed television "Terrific Witchcraft," while<i>Harper's</i>questioned, "Where Does Television Belong?" Other magazines speculated about its role in education, in the library, in viewing surgical operations, and as a "new aid to recreation." Although television's development was interrupted by World War II, in 1946 the boom began. By 1951, coast-to-coast viewers watched President Harry Truman open the Japanese Peace Treaty Conference in San Francisco, Calif. "Natural color"
Book Notices
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perioperative Prognostic Value of Dipyridamole Echocardiography in Vascular Surgery
Authors: Rosa Sicari, Andrea Ripoli, Eugenio Picano, Ana Djordjevic-Dikic, Raniero Di Giovanbattista, Giovanni Minardi, Simon Matskeplishvili, Sergei Ambatiello, Giovanni Pulignano, Mario Accarino, Anna Maria Lusa, Gian Franco Del Rosso, Roberto Pedrinelli, Yuri Buziashvili
Journal: Circulation (1999)

Background —Patients undergoing major vascular surgery are at a relatively high risk of cardiac events, and pharmacological stress echocardiography is increasingly used for perioperative risk stratification. The aim of the current study was to evaluate the value of dipyridamole echocardiography test (up to 0.84 mg/kg over 10 minutes) in predicting cardiac events in a large-scale, multicenter, prospective, observational study design. Methods and Results —Five hundred nine patients (mean age 66±10 years) were studied before vascular surgery by dipyridamole stress echocardiography in 11 different centers. All patients underwent preoperative clinical risk assessment according to the American Heart Association guidelines. No major complications occurred during dipyridamole stress echocardiography. Technically adequate images were obtained in all patients; however, in 4 patients only the low dipyridamole dose (0.56 mg/kg over 4 minutes) was given for limiting side effects. Eighty-eight (17.3%) had a positive test. Perioperative events occurred in 31 (6.1%) patients: 6 deaths, 11 myocardial infarctions, and 14 episodes of unstable angina. Sensitivity and specificity of dipyridamole stress echocardiography for predicting spontaneous cardiac events were 81% and 87%, respectively, with a positive predictive value of 28% and negative predictive value of 99%. By multivariate analysis, the difference between wall motion score index at rest and peak stress (Δwall motion score index), test positivity, and ST-segment depression during dipyridamole infusion were independent predictors of any perioperative cardiac event. Conclusions —Dipyridamole stress echocardiography is safe and well tolerated in patients undergoing major vascular surgery and provides an effective preoperative screening test for the risk stratification of these patients, mainly because of the extremely high negative predictive value, which is a potent predictor of complication-free procedure.
Moderated ePoster Session 1
Authors: A Shoaib, ; Yasin, ; Perveen, ; Goode, ; Shahid, ; Rigby, ; Wong, A Clark, ; Swedberg, N Sato, ; Kajimoto, ; Takano, K Bury, ; Zalewski, ; Furman, ; Opolski, ; Polonski, ; Szelemej, E Straburzynska-Migaj, ; Niedziela, ; Drozdz, ; Nessler
Journal: European Journal of Heart Failure (2014)
Infrared thermometry for reading reactions on darkly pigmented skin
Authors: H. S. Kaufman
Journal: JAMA (1967)

Skin temperature, as measured by infrared radiation, is increased by the active hyperemia associated with a positive immediate skin test reaction in allergic individuals. An objective method for reading, recording, and quantitating such increases in temperature is possible with the use of a new instrument. This method may prove to be especially useful in identifying the degree of reaction on heavily pigmented skins, where the erythema of the reactions is difficult or impossible to see.
Intermediate term cardiorespiratory capacity after surgical closure of atrial septal defect in adults Gruschen R. Veldtman, Per Morten Fredriksen, Vanessa Razack, Akane Nishimoto, Sloane Hechter, Mohammed A. Warsi, John Granton, Gary D. Webb, Michael Gatzoulis. Toronto Conogenitak Cardiac Centre for Adults, Toronto, Canada, Toronto, Canada
Journal: Journal of the American College of Cardiology (2001)
Detection of Mitotic and Meiotic Aneuploidy in the Yeast Saccharomyces cerevisiae
Authors: James M. Parry, D. Sharp, Elizabeth M. Parry
Journal: Environmental Health Perspectives (1979)

A number of genetic systems are described which involve the use of the yeast Saccharomyces cerevisiae. The systems may be used to detect the production of aneuploid cells produced during both mitotic and meiotic cell division in the presence of genetically active chemicals. During mitotic cell division, monosomic colonies (2n - 1) may be detected by plating upon selective medium. Increases in such monosomic colonies are produced by exposure of cells to a number of chemical mutagens such as ethyl methane-sulfonate and mitomycin C. More importantly, monosomic colonies are also induced by nonmutagens such as sulfacetamide and saccharin, which suggests that such chemicals are capable of inducing aneuploidy (aneugenic) in the absence of mutagenic activity. Genetic analysis of aneuploid colonies produced on nonselective medium indicate that at least a proportion of the monosomic colonies were the result of mitotic nondisjunction. During meiotic cell division, disomic cells (n + 1) produced by chromosome nondisjunction may be detected by plating on selective media. The frequency of disomic cells has been shown to increase after exposure to p-fluorophenylalanine.
Abstract 1476: Angiotensin II Induced Hypertrophic Response And Oxidative Stress Is Attenuated In Mice Lacking The Gene For Tnf-α
Authors: Srinivas Sriramula, Nithya Mariappan, Elizabeth McILwain, Joseph Francis
Journal: Circulation (2007)

Tumor necrosis factor-alpha (TNF-α) and angiotensin II (Ang II) play an important role in the pathophysiology of cardiovascular disease in part by inducing the cardiac hypertrophic response and oxidative stress. Recently we demonstrated that angiotensin induced hypertensive response is attenuated in mice lacking the gene for TNF-α. In this study, we examined whether Ang II induced cardiac hypertrophy and increased oxidative stress is mediated through TNF-α. Methods and results: Male TNF-α (−/−) and age matched control (WT) mice were subcutaneously implanted with osmotic minipumps containing Ang II (1 μg/kg/min) or saline for 14 days. Human recombinant TNF-α was injected in one group of TNF-α (−/−) mice (10 μg/kg/day) for 14 days. In WT+Ang mice, a temporal increase in blood pressure was observed during the study as measured by radio telemetry transmitters. At the end of the study, echocardiography revealed an increase in thickness and dimensions of left ventricle (LV) and decreased fractional shortening (%FS) in WT+Ang mice. Real time RT-PCR showed that Ang II- infusion resulted in an increase in heart/bodyweight ratio and of cardiac hypertrophy markers ANP and BNP, and profibrotic genes Collagen Type I, Collagen Type II, and TGF-β in WT mice. Electron Spin resonance spectroscopy revealed an increase in total ROS, superoxide and peroxynitrite in the WT+ANG mice when compared to control WT mice. However, these changes were all attenuated in TNF-α (−/−)+Ang mice. Ang II infusion also increased significantly the mRNA expression of gp91Phox, NOX-1, NOX-4 and AT1R in the LV of WT mice, but not in TNF-α (−/−) mice. Interestingly, injection of TNF-α in the TNF-α (−/−) mice, treated with Ang II resulted in increased cardiac hypertrophy and oxidative stress. Conclusions: Findings from the present study suggest that TNF-α plays an important role in the development of cardiac hypertrophy and oxidative stress in Ang II-induced hypertension.
Editorial Board
Authors: Roy Patterson, Charles Madison, Kurt Bosmn, Merrill Chase, New York, Jordan Fink, Bernard Levine, William Solomon, Ann Arbor, Douglas Heiner, John David, Gerald Gleich, Rochesrer Minn, Charles Kirkpatrick, Richard Steihm, Los Angeles, Monroe Stamford, Richard Madison, John Ohman, Hal Richerson, Ross Rocklin, Raymond Slavin, Sf Loui>, Robert Stroud, Harvey Colten Boston, Fred Kantor, New Haven, Robert Schwartz Rochester, John Yunginger, Burton Zweiman, Oscar Frick, San Francisco, Secretary Frank, Austen Boston, Thomas Van Metre, Robert Baltimore Treasurer, Charles Reisman, Denver May, Samuel Historian, K Frank, I Leonard, Bernstein Cincinnati, Rebecca Buckley, Durham Samuel, Oscar Freedman Montreal, San Frick, Charles Francisco, Philip Denver, Roy Norman Bahimore, Robert Patterson Chicago, Raymond Reisman Buffalo, St Slavin, Thomas Louis
Journal: Journal of Allergy and Clinical Immunology (1977)
Erratum: “Estimated Changes in Life Expectancy and Adult Mortality Resulting from Declining PM2.5 Exposures in the Contiguous United States: 1980–2010”
Authors: Neal Fann, Sun-Young Kim, Casey Olives, Lianne Sheppard
Journal: Environmental Health Perspectives (2018)

[This corrects the article DOI: https://doi.org/10.1289/EHP507.].
Chronic Nasal Sinusitis and Its Relation to General Medicine (Chronic Sinusitis and Systemic Sepsis)
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consultant Contract
Authors: S. R. Brennan
Journal: BMJ (1975)

<h3>Background</h3> The predictive value of serum neurofilament light chain (sNfL) on long-term prognosis in multiple sclerosis (MS) is still unclear. <h3>Objective</h3> Investigate the relation between sNfL levels over a 2-year period in patients with relapsing-remitting MS, and clinical disability and grey matter (GM) atrophy after 10 years. <h3>Methods</h3> 85 patients, originally enrolled in a multicentre, randomised trial of ω−3 fatty acids, participated in a 10-year follow-up visit. sNfL levels were measured by Simoa quarterly until month 12, and then at month 24. The appearance of new gadolinium-enhancing (Gd+) lesions was assessed monthly between baseline and month 9, and then at months 12 and 24. At the 10-year follow-up visit, brain atrophy measures were obtained using FreeSurfer. <h3>Results</h3> Higher mean sNfL levels during early periods of active inflammation (Gd+ lesions present or recently present) predicted lower total (β=−0.399, p=0.040) and deep (β=−0.556, p=0.010) GM volume, lower mean cortical thickness (β=−0.581, p=0.010) and higher T2 lesion count (β=0.498, p=0.018). Of the clinical outcomes, higher inflammatory sNfL levels were associated with higher disability measured by the dominant hand Nine-Hole Peg Test (β=0.593, p=0.004). Mean sNfL levels during periods of remission (no Gd+ lesions present or recently present) did not predict GM atrophy or disability progression. <h3>Conclusion</h3> Higher sNfL levels during periods of active inflammation predicted more GM atrophy and specific aspects of clinical disability 10 years later. The findings suggest that subsequent long-term GM atrophy is mainly due to neuroaxonal degradation within new lesions.
Erratum: “A Prospective Study of Growth and Biomarkers of Exposure to Aflatoxin and Fumonisin during Early Childhood in Tanzania”
Journal: Environmental Health Perspectives (2015)

discovered errors in the models used for analyses of the joint effects of aflatoxin and fumonisin.After they ran the corrected joint-effects models, it became clear that the data were not sufficient to produce interpretable results.Therefore, the authors removed the joint-effects analyses from their manuscript, including information in the Abstract, "Materials and Methods," and "Results."Table 5 was also removed, but the main effects of aflatoxins have been added to the "Results."In addition, Yu-Kang Tu, a biostatistician, was added as a coauthor.The authors regret the errors.
National Institutes of Health (NIH) Consensus Development Conference on Health Implications of Smokeless Tobacco Use
Journal: JNCI Journal of the National Cancer Institute (1985)

National Institutes of Health (NIH) Consensus Development Conference on Health Implications of Smokeless Tobacco Use Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 4, October 1985, Page 799, https://doi.org/10.1093/jnci/75.4.799-a Published: 01 October 1985