tbuckley/cabot-search huggingface dataset:
Contributions to Embryology. Volume XXIX, Nos. 179 to 186
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The symbiotic supplementation modulate gut microbiota, regulation beta-catenin expression and prevents weight gain in ob/ob mice with non-alcoholic fatty liver disease (NAFLD)
Authors: Sebastião Mauro Bezerra Duarte, Jose Tadeu Stefano, Lucas A.M. Franco, Roberta Cristina Ruedas Martins, Denise Frediani Barbeiro, Junia Marielle Teixeira Rodrigues Neri, Bruno Cogliati, Ester Cerdeira Sabino, Flair Jose Carrilho, Claudia Oliveira
Journal: Journal of Hepatology (2020)
Probiotic supplements
Authors: D. A. Osborn, J. K. H. Sinn
Journal: BMJ (2013)

A specialist Clinical Psychology Service in Primary Care was set up in one health district in 1979 on a three-year experimental basis. A survey conducted among the general practitioners who had used the service during this period found a high level of satisfaction. The views of the general practitioners are reported and also their ratings of the outcome of psychological treatment in each of 305 cases. The relationship between certain patient characteristics and treatment outcome is also presented. These results are discussed in relation to further research required in this area and the future of liaison between clinical psychologists and general practitioners.
Acta Physiologica Latino Amer, Buenos Aires
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The comparison between UGT1A1 single heterozygous and wild type regarding the clinical outcomes of fixed dose irinotecan monotherapy for advanced gastric cancer: Multicenter retrospective study
Authors: T. Sasaki, S. Nakano, S. Yuki, K. Sawada, T. Muranaka, Y. Kawamoto, H. Nakatsumi, T. Ando, H. Yoshita, K. Harada, Y. Kobayashi, T. Miyagishima, K. Hatanaka, A. Tanimoto, A. Ishiguro, T. Honda, M. Dazai, Y. Komatsu
Journal: Annals of Oncology (2019)
Adult Endomyocardial Fibrosis in Britain
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MBRS-50. PEROXIREDOXIN1 IS A THERAPEUTIC TARGET IN GROUP-3 MEDULLOBLASTOMA
Authors: Babu Sajesh, Ngoc On, Refaat Omar, Holly Fediuk, Lin Li, Samaa Alrushaid, W Wang, J Pu, H D Sun, Teruna Siahaan, Tamra Werbowetski-Ogilvie, Matthias Wolfl, Marc Remke, Vijay Ramaswamy, Michael Taylor, Charles Eberehart, Marc Symons, Rosa Maria Ruggieri, Donald Miller, Issai Vanan
Journal: Neuro-Oncology (2018)

Group-3 medulloblastoma (MBL) is highly resistant to radiation (IR) and chemotherapy and has the worst prognosis. Hence, there is an urgent need to elucidate targets that sensitize these tumors to chemotherapy and IR. Employing standard assays for viability and sensitization to IR, we identified PRDX1 as a therapeutic target in Group-3 MBL. Specifically, targeting PRDX1 by RNAi or inhibition by Adenanthin led to specific killing and sensitization to IR of Group-3 MBL cells. We rescued sensitization of Daoy and UW228 cells by hypermorphic expression of PRDX1. PRDX1 knockdown caused oxidative DNA damage and induced apoptosis. We correlated PRDX1 expression to patient outcomes in a validated MBL tumor-microarray. Whole genome sequencing identified pathways/genes that were dysregulated with PRDX1 inhibition or silencing. Our in vivo studies in mice employing flank/orthotopic tumors from patient derived xenografts/Group-3 MBL cells confirmed in vitro observations. Animals with tumors in which PRDX1 was targeted by RNAi or Adenanthin (using mini osmotic pumps) showed decreased tumor burden and increased survival when compared to controls. Since, Adenanthin does not cross the blood brain barrier (BBB) we used HAV6 peptide to transiently disrupt the BBB and deliver Adenanthin to the tumor. Immunohistochemistry confirmed that targeting PRDX1 resulted in increased oxidative DNA damage, apoptosis and decreased proliferation. In summary, we have validated PRDX1 as a therapeutic target in group-3 MBL, identified Adenanthin as a potent chemical inhibitor of PRDX1 and confirmed the role of HAV peptide (in the transient modulation of BBB permeability) in an orthotopic model of group-3 MBL.
Annals of Internal Medicine, Philadelphia
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolic Alkalosis
Authors: Fredric L. Coe
Journal: JAMA (1977)

METABOLIC ALKALOSIS, a primary increase in the alkali content of the blood, is commonly seen in hospital practice. Increase in blood pH reduces ionized calcium concentration and can lead to tetany. The irritability of the CNS increases and convulsive tendencies are aggravated. Respiration can be depressed. Electrocardiographic changes resemble those of hypokalemia. Especially in patients receiving digitalis, or when there already exists serious systemic disease, alkalosis may be a potentially serious hazard.<sup>1</sup> <h3>DEFINITION OF METABOLIC ALKALOSIS</h3> As the Pco<sub>2</sub>of blood rises above the normal value of 40 mm Hg, blood pH falls (so-called respiratory acidosis). Progressive reduction of Pco<sub>2</sub>, below normal, leads to elevated blood pH (respiratory alkalosis). The actual confidence band relating pH to Pco<sub>2</sub>of arterial blood has been experimentally determined.<sup>2</sup>Metabolic alkalosis is defined by a blood pH above that predicted for the prevailing Pco<sub>2</sub>, for only removal of excessive
Principles and Practice of X-Ray Technic for Diagnosis.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asbestos bodies and their bioeffects
Authors: R. T. DeTreville
Journal: JAMA (1968)

<h3>To the Editor:—</h3> This letter outlines the history of the asbestos body from its discovery through a period of little clinical significance to the present day when it holds the position of being possibly one of the greatest industrial medical problems of the age. <h3>Asbestos:—</h3> Asbestos is a general term that covers a number of minerals of which four are of commercial importance: crocidolite from the Republic of South Africa, amosite also mined chiefly in the Republic of South Africa, chrysolite which occurs in many countries of the world, and anthophyllite which is mined mainly in Europe. <h3>Asbestosis:—</h3> This is a type of lung fibrosis in workers exposed to large amounts of asbestos dust. It may or may not be associated with recognizable clinical disease during life and is produced by all types of asbestos. Asbestosis was recognized as an industrial disease at the turn of the century, but at
Q Fever and Hepatitis
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Competitive Examinations.
Authors: None R.
Journal: JAMA (1899)

<h3>Cincinnati, Ohio, May 2, 1899.</h3><h3>To the Editor:</h3> —The letter of Dr. Bayard Holmes in last week'sJournal(see April 29, p. 927) meets with my hearty approval. I am and long have been convinced that a written examination, as an exclusive means of determining qualifications in any department, is fallacious. As a means of determining the ability of candidates for hospital interneships, it is strikingly defective. I have no objection to written examinations as one way of finding out what a person may know, but they ought to occupy a subordinate place in the general plan of investigation. The reform method should embrace all that is now included in the written examinations, plus test exercises in the laboratories, in the mortuary and at the bedside of the sick. When this comprehensive plan is adopted, examining bodies may ascertain approximately what candidates may or may not know, and that is
Expression of a novel T cell activation antigen on intrahepatic CD8+ T lymphocytes in viral chronic active hepatitis
Authors: C. García-Monzón, R. Moreno-Otero, J.M. Pajares, A. García-Sánchez, M. López-Botet, M.O. de Landázuri, F. Sánchez-Madrid
Journal: Journal of Hepatology (1989)
Weight-Loss Regimens Among Overweight Adults— Behavioral Risk Factor Surveillance System, 1987
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigation of the Potential for Binding of Di(2-Ethylhexyl) Phthalate (DEHP) to Rat Liver DNA in Vivo
Authors: Werner K. Lutz
Journal: Environmental Health Perspectives (1986)

It was the aim of this investigation to determine whether or not covalent binding of di(2-ethylhexyl) phthalate (DEHP) to rat liver DNA could be a mechanism of action contributing to the observed induction of liver tumors after lifetime feeding of rodents with high doses of DEHP.DEHP radiolabeled in different positions was administered orally to female F344 rats with or without pretreatment for 4 weeks with 1% unlabeled DEHP in the diet.Liver DNA was isolated after 16 hr and analyzed for radioactivity.Administration of [14C]carboxylate-labeled DEHP resulted in no measurable DNA radioactivity.With DEHP ["4C]-and [3H]- labeled in the alcohol moiety as well as with 2-ethyl[1-14C]hexanol, radioactivity was clearly measurable in the DNA.HPLC analysis of enzyme-degraded DNA revealed that the normal nucleosides had incorporated radiolabel whereas no radioactivity was detectable in those fractions where the carcinogen-modified nucleo- side adducts are expected.A quantitative evaluation of the negative data in terms of a limit of detection for a covalent binding index (CBI) indicates that covalent interaction with DNA is highly unlikely to be the mode of tumorigenic action of DEHP in rodents.
Prolonged patency of a Beck 2 anastomosis complicated by recurrent bacteremia
Authors: R. D. Conn
Journal: JAMA (1966)

The Beck 2 aorta-coronary sinus anastomosis was performed on a number of patients with angina pectoris in the early 1950's. The case described herein represents the longest persistently patent Beck 2 anastomosis, and the only known instance of recurrent bacteremia occurring as a complication of this operation. This case is of further interest in that it points out many of the systemic complications of staphylococcal bacteremia and, to our knowledge, is the only reported instance of Staphylococcus aureus infection of an acquired arteriovenous fistula.
Clinical Physiology
Authors: Frederic Jung
Journal: JAMA (1961)

This book, according to the preface, is written by practicing clinicians in an attempt to fill a gap in medical education left by a dearth of courses and textbooks on applied physiology and functional pathology. The 15 chapters touch on the customary subjects with some notable exceptions, namely, the sense organs, brain, spinal cord, and peripheral nerves. Each chapter, as a rule, consists of 4 sections, dealing with normal functions, disordered functions, principles underlying functional tests, and practical methods of assessment. This last section generally includes a table of normal values, which winds up the chapter with a concreteness that is one of the best features of the book. By contrast, the introductory sections are sometimes vague, superficial, and quite misleading. Some examples are the careless statements on page 1 that "the amount of water in an individual is more closely related to height than to weight, because weight depends
Toxoplasmosis: A Clinical, Serological and Histopathological Study with Special Reference to the Eye Manifestations. Presentation of Twenty Cases of Proved or Presumable Toxoplasmic Retinopathy and Retino-Encephalopathy with Associated Ocular Manifestations
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MicroRNA-mediated Regulation of Ubc9 Expression in Cancer Cells
Authors: Fangting Wu, Shuomin Zhu, Yanna Ding, William T. Beck, Yin-Yuan Mo
Journal: Clinical Cancer Research (2009)

As an E2-conjugating enzyme for sumoylation, Ubc9 plays a critical role in sumoylation-mediated cellular pathways, ultimately impacting cell growth and cancer development. The aim of this study was to investigate the regulation of Ubc9 in cancer cells.Immunohistochemistry and Western blot were used to determine Ubc9 expression in paraffin-embedded tumor tissue and frozen specimens of the matched tumors from the same patient, respectively. To establish the causal relationship between miR-30e and Ubc9 expression, we overexpressed miR-30e and then determined the resultant effects on Ubc9 expression. To determine whether miR-30e directly targets Ubc9, we did luciferase assays using luciferase reporters carrying the 3'-untranslated region (3'-UTR) of the Ubc9 gene.We found that Ubc9 is up-regulated in breast, head and neck, and lung cancer specimens. In addition, an examination of eight pairs of matched breast tumor specimens by Western blot analysis revealed that, on average, the level of Ubc9 is 5.7-fold higher in tumor than in the matched normal breast tissue. Of interest, we present evidence that Ubc9 is subjected to posttranscriptional regulation by microRNA, and the miR-30 family, such as miR-30e, negatively regulates Ubc9 expression. In contrast to Ubc9, miR-30e is underexpressed in tumors. Moreover, ectopic expression of miR-30e suppresses cell growth, which can be partially reversed by Ubc9. Finally, using luciferase-Ubc9-3'-UTR reporters, we show that Ubc9 is a direct target for miR-30e by interactions with the putative miR-30e binding sites.These results provide new insight into regulation of Ubc9 in cancer cells.
Radiation menopause.
Authors: W G Mills
Journal: BMJ (1972)

motor neuropathy postoperatively could have been due to the provocation of an attack of porphyria if the anaesthetic of nitrous oxide and oxygen was induced by an intravenous barbiturate.Though this would be an atypical presen- tation, one wonders whether the possibility of porphyria should be excluded, if this has not already been done, since this would be of interest should the patient ever be considered in the future for a procedure needing a general anaesthetic.-Iam, etc.,