tbuckley/cabot-search huggingface dataset:
THE SURGEONS AT HOMESTEAD.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Justification of a single 6-month course of interferon (IFN) for histologically mild chronic hepatitis C 1, Inoue Y2,3, Beek JR2, Pauker SG4, Davis GL1. 1Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL; 2Office of Information Technology, Baylor College of Medicine, Houston, TX; 3Dept of Medicine, Yamaguchi University of Medicine, Japan, 4New England Medical Center, Tufts University, Boston
Journal: Hepatology (1995)

Basándonos en los datos ya conocidos sobre el comportamiento de los mecanismos de transmisión del sonido, creamos un modelo que reproduce la actividad mecánica del oído medio, utilizando el método de los elementos finitos. Diseñamos un modelo computadorizado que simula el comportamiento biomecánico de la membrana timpánica y la cadena osicular. Centramos el interés de la investigación en sus posibles aplicaciones clínicas, pudiendo introducir en el modelo las variables necesarias para la simulación de distintas situaciones: perforaciones timpánicas, fijaciones osiculares, interrupciones de la cadena, etc. Suministrando al programa simulador las características de la lesión creamos un modelo virtual sobre el que podemos valorar la hipoacusia existente y las posibilidades terapéuticas. Realizamos este modelo 3-D de membrana timpánica, martillo, yunque y estribo considerando su forma, peso, densidad, módulo de Young (N/m2) y coeficiente de Poisson, para las diferentes partes del sistema. Mostramos también la modelización de los elementos de unión entre los diferentes elementos tímpano-osiculares, incluidos músculos y ligamentos.Based on known data about the behavior of the sound transmission mechanism, we generate a model that reproduces the real mechanics of the middle ear by the finite elements method in the most exact manner possible. We designed a computerized model to simulate the biomechanic behavior of the ear drum / ossicular chain. The investigation focused on a possible clinical application, given that the variables neccesary for simulation of several conditions can be introduced in our model: tympanic perforation, fixation of the ossicular chain, chain interruption, etc. Introducing the characteristics of the lesion virtually in a simulator program maket is possible to reach conclusions about the conductive hypoacusis created and about therapeutic possibilities. The 3-D modelling of the tympanic membrane, malleus, incus and stapes is presented, considering form, weight, density, Young’s module (N/m2) and Poisson coefficient for the different parts of each ossicle. The modeling of the union of the different tympanic-ossicular elements, including muscles and ligaments, is also shown.
LETTER FROM LONDON.
Authors: None G. O. M.
Journal: JAMA (1890)

<h3>(FROM OUR OWN CORRESPONDENT.)</h3> <i>Dr. Bernheim and Hypnotism—Somnal—Ambulance Service—Dr. Gervis on Puerperal Fever— The Leprosy Committee</i>. The event in the scientific world is Dr. Bernheim's demonstration at the Hotel Dieu, that suggestion does not depend on hypnotism. Dr. Bernheim heads the Nancy school as opposed to the Paris or Charcot school. He experimented in the presence of most of the medical staff, the leading judges d'instruction, advocates, and of M. Dumas<i>fils</i>, who came to see to what degree his father's intuitions would be borne out. None of the patients knew anything of Bernheim nor had any idea why he came among them. Each set was taken in a different ward from the other. The Nancy scientist who first discovered this power in a common man, made suggestions to the patients in a state of natural sleep, and then to waking ones. Without trying to hypnotize them he was able
Contribution of Formaldehyde to Respiratory Cancer
Authors: Norton Nelson, Richard J. Levine, Roy E. Albert, Aaron E. Blair, Richard A. Griesemer, Phillip J. Landrigan, Leslie T. Stayner, James A. Swenberg
Journal: Environmental Health Perspectives (1986)

This article reviews the available data on the carcinogenicity of formaldehyde from experimental and epidemiologic studies and makes recommendations for further research. Two definitive chronic inhalation bioassays on rodents have demonstrated that formaldehyde produces nasal cancer in rats and mice at 14 ppm and in rats at 6 ppm, which is within the domain of present permissible human exposure (8-hr time-weighted average of 3 ppm, a 5 ppm ceiling, and a 10 ppm short-term exposure limit). Biochemical and physiologic studies in rats have shown that inhaled formaldehyde can depress respiration, inhibit mucociliary clearance, stimulate cell proliferation, and crosslink DNA and protein in the nasal mucosa. No deaths from nasal cancer have been reported in epidemiologic studies of cohorts exposed to formaldehyde, but three case-control studies suggest the possibility of increased risk. Although excesses of lung cancer deaths have been observed in some studies at industrial plants with formaldehyde exposure, uncertainties in interpretation limit the evaluation of these findings. Excess cancers of the brain and of lymphatic and hematopoietic tissues have been reported in certain studies of industrial groups and in most studies of formaldehyde-exposed professionals, but whether these excesses are related to formaldehyde exposure is not known. Several properties of formaldehyde pose unique problems for future research: the mechanisms responsible for its nonlinear response; its probable mechanism of carcinogenic action as a cross-linking agent; its formation in tissues as a normal metabolite; its possible action as a promoter and/or a cocarcinogen; and the importance of glutathione as a host defense at low exposure.
Handbuch der Röntgentherapie.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tophaceous Gout
Authors: Edwin J. Green
Journal: JAMA (1977)

THE CARPAL tunnel syndrome is a compression neuropathy of the median nerve caused by its entrapment in the carpal tunnel. The clinical diagnosis is based on the presence of thenar muscle weakness and atrophy and paresthesias in the distribution of the median nerve. The carpal tunnel syndrome was first described in 1854 and has been extensively defined by Phalen over the last two decades.<sup>1</sup>Common causes of carpal tunnel syndrome are rheumatoid arthritis, diabetes mellitus, and trauma; gout is a rare cause.<sup>2</sup>We report an unusual case of tophaceous gout causing bilateral carpal tunnel syndrome. <h3>See also p 2746.</h3><h3>Report of a Case</h3> A 40-year-old man had a three-year history of gout. His initial attack, in 1972, was characterized by exquisitely painful swelling and redness of both first metatarso-phalangeal joints. He had one or two attacks of acute arthritis per month for the next year, and well-defined nodules
Counterimmunoelectrophoresis and bacterial meningitis
Authors: A. C. Hamoudi
Journal: JAMA (1978)

<h3>To the Editor.—</h3> We read with interest both letters concerning counterimmunoelectrophoresis (CIE) and bacterial meningitis by Denis et al (238:1248, 1977) and Eckfeldt et al (239:615, 1978). We thought it would be helpful to state our own findings. We believe that CIE is a useful, specific, rapid diagnostic test in a pediatric hospital. We would also like to emphasize the value of including serum and urine in CIE studies on meningitis to increase the sensitivity of the test. From August 1976 through May 1978, we ran CIE on 284 clinical specimens. Of these, 181 cases were negative on CIE and cultures and were subsequently found to have no bacterial infection or infections due to causes other than the antigens we were testing for, namely,<i>Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae</i>, or group B streptococci. In all of these specimens we ran across no crossreactions or false-positives. Table 1 summarizes our
<i>A Text-Book of Insanity.</i>By Charles Mercier, M. B., M. R. C. P., F. R. C. S., Lecturer on Insanity at the Westminster Hospital Medical School and at the London Medical School for Women. London: Swan Sonnenschein &amp; Co., Limited. New York: The MacMillan Company. 1902
Journal: American Journal of Psychiatry (1903)
Reduction of Bacteriuria and Pyuria Using Cranberry Juice
Authors: Walter J. Hopkins
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Dr Avorn and colleagues<sup>1</sup>report that daily ingestion of cranberry juice may reduce the frequency of bacteriuria and pyuria in older women. We believe, however, that problems in experimental design and data analysis lessen the validity of their conclusions. First, the power calculations have been performed for an infection rate that is not reflected in the study population. The authors assume a 50% infection rate, which is apparently the proportion of subjects that are expected to have at least one infection during the 6-month study period. This rate seems high in light of their own baseline data indicating that no more than 25% of treatment or control subjects had a urinary tract infection (UTI) in the preceding 6 months. Furthermore, the authors never present the observed proportion of UTIs for either group, even though the study was apparently designed around this endpoint. Second, the authors note
Oxaliplatin associated neurotoxicity outcomes among older adults with colorectal cancer: a population-based study.
Authors: Michael J. Raphael, Hadas Fischer, Kinwah Fung, Peter Austin, Geoffrey Anderson, Christopher M. Booth, Simron Singh
Journal: Journal of Clinical Oncology (2016)

e18034 Background: The addition of oxaliplatin to fluorouracil-based regimens in the adjuvant treatment of colorectal cancer (CRC) has been shown to improve overall survival at the expense of increased toxicity. Toxicity may be higher among older patients who may also derive less benefit from oxaliplatin. The true incidence of toxicity in the elderly is unknown. Methods: A cohort of patients ≥ 66 years old diagnosed with Stage II and III CRC between 2007 and 2011 in Ontario, Canada was identified using the Ontario Cancer Registry. Patients were stratified by age and oxaliplatin exposure. Linked administrative databases were then used to identify patients who were subsequently diagnosed with peripheral neuropathy (PN) or received a new prescription for a neuropathic pain medication. Cause-specific hazard models were used to estimate the effect of oxaliplatin exposure on the cause-specific hazard (CHR) of PN after accounting for the competing risk of death. Results: We identified 3,607 patients ≥ 66 years old with Stage II and III CRC, of whom 1,541 were treated with an oxaliplatin-based AC regimen. By the end of one year, the cumulative incidence of PN was 3.2% (95% CI, 2.0-4.8) for ages 66-69 and 5.5% (95% CI, 4.1-7.2) for age ≥ 70 among those treated with an oxaliplatin-based AC regimen. In an adjusted model, patients ≥ 70 years treated with oxaliplatin had a higher rate of PN (CHR, 2.07 [95% CI, 1.43-3.00; p < 0.001]) and new prescriptions for a neuropathic pain medication (CHR, 1.86 [95% CI, 1.43-2.42; p < 0.001]). In patients aged 66-69, oxaliplatin use was not associated with a new diagnosis of PN (p = 0.90). A formal test of interaction confirmed that the effect of oxaliplatin on the occurrence of PN differed between those aged 66-69 and those aged ≥ 70 years (p = 0.03). Conclusions: In this large, population-based cohort, CRC patients ≥ 70 years old treated with oxaliplatin had a significantly higher risk of developing PN and requiring treatment with neuropathic pain medications. Trials specifically designed to evaluate therapeutic options and identify toxicities in the elderly population with cancer are needed.
Serum gamma-glutamyltransferase is a prognostic biomarker in primary biliary cholangitis and improves risk stratification based on the alkaline phosphatase
Authors: Alessio Gerussi, Davide Bernasconi, Sarah Elisabeth O’Donnell, Willem J Lammers, Henk Van Buuren, Gideon Hirschfield, Harry Janssen, Christophe Corpechot, Anna Reig, Albert Pares, Pier Maria Battezzati, Massimo Giovanni Zuin, Nora Cazzagon, Annarosa Floreani, Frederik Nevens, Nikolaos Gatselis, George Dalekos, Marlyn J. Mayo, Douglas Thorburn, Tony Bruns, Andrew L. Mason, Verhelst Xavier, Kris Kowdley, Pietro Invernizzi, Bettina Hansen, Marco Carbone
Journal: Journal of Hepatology (2020)
Correlation between radiographically diagnosed osteophytes and magnetic resonance detected cartilage defects in the tibiofemoral joint
Authors: T. Boegard, O. Rudling, I. F Petersson, K. Jonsson
Journal: Annals of the Rheumatic Diseases (1998)

<h3>OBJECTIVE</h3> To assess the correlation between the presence of radiographically diagnosed osteophytes in the tibiofemoral joint (TFJ) and (1) magnetic resonance (MR) detected cartilage defects and meniscal lesions in the same joint and (2) knee pain. <h3>METHODS</h3> Fifty nine people, 29 men and 30 women, with chronic knee pain (aged 41–58 years, mean 50 years) were examined with posteroanterior weightbearing radiograms in semiflexion of both TFJ. The presence and grade of marginal and central osteophytes were assessed. On the same day, an MR examination was performed of the signal knee with proton density and T2 weighted turbo spin-echo sequences on a 1.0 T imager. Cartilage defects and meniscal abnormalities in the TFJ were noted. The subjects were questioned for current knee pain for each knee. <h3>RESULTS</h3> Marginal osteophytes had a sensitivity of 77%, specificity of 83%, and positive predictive value of 87% for MR detected cartilage defects in the TFJ and a sensitivity of 71%, specificity of 68%, and positive predictive value of 71% for meniscal abnormalities. A correlation (p&lt;0.05) between osteophytes at the medial tibial condyle and knee pain was found. <h3>CONCLUSIONS</h3> With the presence of marginal osteophytes in the TFJ there is a high prevalence of MR detected cartilage defects in the same joint whether joint space narrowing (&lt;3 mm) is present or not.
Autoimmune Pancreatitis
Authors: Dmitry L. Finkelberg, Dushyant Sahani, Vikram Deshpande, William R. Brugge
Journal: New England Journal of Medicine (2006)

Autoimmune pancreatitis is a form of chronic pancreatitis characterized by an autoimmune inflammatory process that may involve the biliary ducts, bowel, regional lymph nodes, and sometimes the lung and kidney. Patients with this uncommon form of pancreatitis may present with an obstructing pancreatic mass that mimics pancreatic cancer but responds to corticosteroid treatment. This review summarizes how the diagnosis of autoimmune pancreatitis can be established on the basis of imaging, histologic, and serologic criteria.
Correction:<i>What is axial spondyloarthritis? A latent class and transition analysis in the SPACE and DESIR cohorts. A meta-analysis and functional study</i>
Journal: Annals of the Rheumatic Diseases (2020)

The values for some of the features in the SPACE cohort were switched between patients included and excluded in the analysis.The appropriate corrections were made in table 1 and online supplementary table S1.The text in the results section was also corrected: "In SPACE, included patients were less likely to be HLA-B27 positive (37% vs5 7%) (…)".Table 1 Baseline patient characteristics in the space and DESIR cohorts Space (n=465) Desir (n=576) Age at baseline (years) 31 (8) 33 (8) Male gender 161 (35) 269 (47) Symptom duration (years) 1.8 (2.3) 1.5 (0.8) ASAS axSpA criteria 172 (37) 358 (62) axSpA according to Rheumatologist* 136 (30) 269 (47) ASAS pSpA criteria 182 (39) 320 (56) ASAS SpA criteria † 249 (54) 443 (77) Sacroiliitis on MRI-SIJ (ASAS) 64 (14) 153 (27) BME on MRI-spine (≥5 lesions) 21 (5) 25 (4) Radiographic sacroiliitis (mNY) 38 (8) 78 (14) ≥1 syndesmophyte on X-spine 15 (3) 39 (7) Elevated CRP (≥6 mg/L) 118 (25) 169 (29) Good response to NSAIDs ever 189 (41) 491 (85) Peripheral arthritis ever 76 (16) 122 (21) Dactylitis ever 23 (5) 78 (14) Heel enthesitis ever 91 (20) 261 (45)
President Kennedy's adrenals
Authors: J. Nichols
Journal: JAMA (1967)

While the late President Kennedy held public office, an aura of mystery prevailed regarding his endocrine status. During his campaign for, and brief tenure of, the presidency, rumors circulated that he suffered from chronic adrenocortical insufficiency (Addison's disease). Credence was given to these rumors by failure of his attending physicians to deny the allegations. Since his death, speculation continues partially related to failure of federal officials to release pertinent data.<sup>1,2</sup>This is in marked contrast to the intimate details of President Eisenhower's several illnesses which were given wide dissemination in various news media. The moral and ethical issues were carefully considered by Lt Gen L. D. Heaton and his associates<sup>3</sup>when they concluded the world had a right to know of the medical details of President Eisenhower's operation for regional enteritis. President Eisenhower agreed with this. This writer also agrees that the public is entitled to knowledge of
SOME OF THE INDICATIONS FOR VASECTOMY.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DR. ADAMI'S CROONIAN LECTURES
Authors: J. G. Adami
Journal: BMJ (1917)

a registered return envelope.The voters wouldenter on them tlje narmes of thie tlhree most suitable men for a Mini.ster of Health.The tlhirty lhaving the lUrgest number of votes could m-eet in London soon after, and electLfrom their number tlhe very best man for the position.The subclhiefs could be clhosen froin the remainider.There may be some otlher anid better way, and, if so, we should hear about it now.Sucehi a Minister of Health would soon set the machlinery in motion for thie betterment of tlle health of the nation.He knows already,, as do most of
Forcible administration of antipsychotic medication. State laws
Authors: H. R. Arkin
Journal: JAMA (1984)

THE USE of powerful antipsychotic drugs in state mental institutions is perhaps the most controversial current issue in psychiatry. There is disagreement over both the effectiveness and the side effects of these drugs, and critics contend that they are used more for controlling behavior in crowded institutions than for treatment. With growing numbers of involuntarily committed patients refusing antipsychotic drugs, state and federal courts have been called on to determine and balance the rights of patients and the duties of the state. The legal dilemmas are far from resolved, but the courts are addressing them and are bringing some clarification to the issues. A qualified constitutional right to refuse antipsychotic, or psychotropic, medication has been recognized by a number of federal courts, particularly in Massachusetts and New Jersey (<i>JAMA</i>1983;249:2784-2785). These courts have disagreed, however, on the specific constitutional source that creates such a right as well as on the
THE USE OF 3D VIRTUAL REALITY IN ENDO-ULTRASONOGRAPHY FOR RECTAL ADENOCARCINOMA: A NEW CONCEPT, FOR A NEW SOFTWARE APPLICATION (HTTPS://WWW.3D-EUS.FR)
Authors: M Cassagnou
Journal: Endoscopy (2020)

Aims MRI and rectal Endo-ultrasonography are key to the locoregional staging of rectal adenocarcinoma. Endo-ultrasonography has been criticised for being imprecise and unsystematic, because of the machine or of the operator. Moreover EUS images can be difficult to interpret for other specialists and for patients, medical records are various and there is usually a lack of systematisation.
Anesthésie, Analgésie, Réanimation, Paris
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal