tbuckley/cabot-search huggingface dataset:
Mutagenic/Carcinogenic Potential of DEHP and MEHP
Authors: I. Tomita, Y. Nakamura, N. Aoki, N. Inui
Journal: Environmental Health Perspectives (1982)

The mutagenic/carcinogenic activities of DEHP and MEHP were studied in bacteria and mammalian cells. MEHP but not DEHP exerted a dose-dependent DNA damaging effect to B. subtilis in Rec-assay. DEHP and MEHP showed mutagenic activities to S. typhimurium TA-100, with and without S-9 mix, respectively. MEHP produced not only the mutation in E. coli WP2B/r but also sister chromatid exchanges (SCE) in Chinese hamster V79 cells. It also induced 8AG/6TG-resistant gene mutations and chromosomal aberrations in the V79 cells. Transplacental administration of DEHP or MEHP to the Syrian golden hamster embryos was carried out by administering DEHP or MEHP to gravid animals on day 11 of gestation, followed by the cultivation of embryonic cells for 15-20 days. Both DEHP and MEHP induced 8AG/6TG-resistant mutation, chromosomal aberrations and morphological transformation in the embryonic cells of the Syrian golden hamster.
CALCULUS ANURIA
Authors: Ernst C. Baynard
Journal: JAMA (1922)

This case is reported because of its rarity and unusual interest. One does not realize how rare the phenomenon is until there is an occasion to look up the subject, on which little has been written. So far as we have been able to review the literature, textbook and journal articles do little more than describe the condition, mentioning its occurrence and giving no detailed study of the cause of this interesting but puzzling renorenal reflex set up by the presence of a calculus in the opposite kidney. <h3>REPORT OF CASE</h3> Mrs. S., aged 37, was admitted to Roper Hospital, Feb. 6, 1921, with a diagnosis of pyelitis complicating a pregnancy of about four months. Cystoscopic examination revealed much mucopurulent material floating freely in a very congested bladder. A No. 6 ureteral catheter was obstructed in the right ureter about 5 cm. from the bladder. This obstruction was passed with
Editorial Board
Authors: Daniel Cattran, P Coates, Andrew Davenport, Tilman Drueke, Paris Ckd, Associated Complications, Masaomi Nangaku, Jai Radhakrishnan, New York, Maria Rastaldi, Brian Reeves, Detlef Schlöndorff, Michael Ross, Qais Al-Awqati, York New, Christina Wyatt, Vic Hasselblad, Jacksonville Zhezhen, Joseph Kim, Yi-Ju Li, , Durham, Dorothea Nitsch, London Ramakrishnan, Anupam Agarwal, Hans Anders, Jonathan Barratt, Daniela Leicester, São Barreto, David Paulo, Tomas Basile, Francois Denver, Joseph Berthoux, Emmanuel Boston, São Burdmann, Giovambattista Paulo, Christos Napoli, Yi-Pu Paris, Erik Chen, Steven Christensen, New Coca, Terence York, London Cook, D Vivette, New Agati, Farhad York, John Danesh, Ian Chicago, Marc De Boer, Antwerp De Broe, Vikas Zurich, St Dharnidharka, Zheng Louis, Adriana Dong, Kai-Uwe Oviedo, Erlangen Eckardt, Eiam-Ong Somchai, Michael Emmett, Dallas Endre, Sydney Evan, Pieter Evenepoel, Sarah Leuven, Denver Faubel, Steven Faul, Danilo Mineola, Jürgen Homburg, Agnes Aachen, Alessia Nashville, Barry Miami, Winston-Salem Freedman, Isehara Masafumi Fukagawa, Vesna Garg, Rochester Garovic, Laguna Glassock, Glenda Niguel, David Gobe, New Goldfarb, Matthew York, Mark Griffin, Angeles Haas, John Haase, Cijiang He, Michelle Hladunewich, Thomas Hostetter, Chi-Yuan Cleveland, San Hsu, Tobias Francisco, Benjamin Huber, St Humphreys, Reiko Louis, Jula Tokyo, Dallas Inrig, Francisco Kirsten Johansen, Roberto Kamyar Kalantar-Zadeh, Iowa Kalil, Yashpal City, Chicago Kanwar, New Kaskel, Krzysztof York, York Kiryluk, Clayton Kitching, Matthias Kopp, Ann Kretzler, Christian Arbor, Christophe Bonn, Paris Legendre, Los Lemley, Adeera Angeles, Philip Levin, Hong Li, Christoph Kong, John Toronto, Rochester Lieske, Jiannong Little, Kathleen Liu, San Liu, Youhua Francisco, Zhi-Hong Liu, Nanjing Liu, Dallas Lu, Matthias Berlin, Johannes Mack, Peter Mann, Hamilton Margetts, Kunihiro Amiens, William Matsushita, Atlanta Mcclellan, Timothy Mehrotra, Palo Meyer, Jeffrey Alto, St Miner, William Louis, Houston Mitch, Jeremiah Moeller, St Morrissey, Rosa Louis, São Moysés, Rama Paulo, Peter Duarte, David Nelson, Clayton Nikolic-Paterson, Atlanta Charles O'neill, Klaus Charlottesville, Juan Olgaard, New Oliver, Ulf York, Mark Panzer, New Perazella, Janos Haven, Los Peti-Peterdi, Laura Angeles, Atlanta Plantinga, Didier Boston, Ambra Charlottesville, Susan Pozzi, Chicago Quaggin, Jochen Reich, Giuseppe Reiser, Sharon Bergamo, Mariano Clayton, Mitchell Rodriguez, Robert Rosner, Simone Safirstein, New Sanna-Cherchi, Antonio York, Kai Santoro, New Schmidt-Ott, Kumar York, La Sharma, Edward Jolla, Katalin Siew, Philadelphia Susztak, C Sydney, Hong Tang, Ravi Kong, Joshua Boston, Jens Denver, Marcello Nashville, Frank Tonelli, Manjeri Van Der Sande, San Venkatachalam, Carsten Antonio, Joel Wagner, Ann Weinberg, Matthew Arbor, Donald Weir, Temple Wesson, Jack Westenfelder, Adam Wetzels, Myles Whaley-Connell, Keng-Thye Wolf, Kwan-Dun Woo, Taiwan Wu, Yusuke Suzuki, Tokyo Zeisberg
Journal: Kidney International (2016)
Response
Authors: P. J. O'DWYER
Journal: JNCI Journal of the National Cancer Institute (1992)

patients receiving BSO treatment.The animal studies show that treatment with ascorbate can prevent effects produced by giving BSO.Thus, ascorbate might be useful as a rescue therapy for patients exhibiting signs of severe glutathione deficiency due to administration of BSO.Differences in ascorbate status might account in part for the variability in response to BSO treatment observed in the patients studied by O'Dwyer et al. ( 7).Some patients with cancer (and others) may voluntarily ingest large doses of ascorbate.It would seem desirable to monitor the dietary intake of ascorbate of such patients and to determine their blood ascorbate levels before and during therapy with BSO.Conceivably, ascorbic acid might in some instances selectively protect glutathione-depleted normal cells as compared with glutathione-deficient tumor cells; this interesting possibility should be studied.
UNIFORMITY IN THE STRENGTH OF TETANUS ANTITOXIN.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magnetic Resonance Imaging of the Abdomen and Pelvis
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recollections of a Rebel Surgeon (and other stories) or in the Doctors' Sappy Days.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Robert W. Buck, John Figgis Jewett
Journal: New England Journal of Medicine (1957)

IMPORTANT NOTICE TO COUNCILORS The Cotting – Woodward Luncheon will be held at 22 Fenway, Wednesday, February 6, 1957, from 11:45 a.m. until 12:45 p.m.The Council will convene immediately after the luncheon. There will be no morning session.Councilors are requested to return the postcard that has been sent out indicating whether they will attend the luncheon, which precedes the Council meeting. No lunch can be provided for councilors who have not returned this card.COMMITTEE ON MATERNAL WELFAREPuerperal SepsisA gravida 8, para 6, died of overwhelming sepsis three hours post partum.After a normal prenatal . . .
Mollaret Meningitis
Authors: Hobart A. Reimann
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Regularly repetitive episodes as a feature of Mollaret meningitis escape attention in articles on the subject. In case 3 of the report by Haynes et al (236:1967, 1976), three-day episodes recurred bimonthly. In articles cited in the communication, episodes came predictably: every 10 to 12 days (Hermans et al<sup>1</sup>), every two weeks (Tynes et al<sup>2</sup>), and every 17 to 18 days (Haynes et al). According to Bruyn et al,<sup>3</sup>"the attacks will occur regularly, with intervals ranging from some weeks to months," as noted in their patients. Gledhill et al,<sup>4</sup>whose patient had monthly episodes, agreed with my proposal that Mollaret meningitis may be another periodic disease.<sup>5</sup>Because of its inflammatory nature, colchicine suppresses episodes as it does in periodic peritonitis. The beneficial effect may represent a therapeutic response, not a spontaneous remission. Evidently, some cases of Mollaret meningitis can be included
Commentaire de travail de Rahmi G et al., pp. 591
Journal: Endoscopy (2014)

See also: Long-term follow-up of patients undergoing capsule and double-balloon enteroscopy for identification and treatment of small-bowel vascular lesions: a prospective, multicenter studyEndoscopy 2014; 46(07): 591-597DOI: 10.1055/s-0034-1365514
Comments From the Editor: Three Down, Two To Go
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Comments From the Editor: Three Down, Two To Go Get access JNCI: Journal of the National Cancer Institute, Volume 59, Issue 2, August 1977, Page 544, https://doi.org/10.1093/jnci/59.2.544-a Published: 01 August 1977
PANCREATIC CYSTS.
Authors: L. L. McARTHUR
Journal: JAMA (1899)

To M. Takayasu belongs the credit for the most exhaustive résumé of recent date on the surgery of the pancreas. He has collected and tabulated all the wellauthenticated and observed cases of pancreatic surgery in the literature, to the number of 104 cases, to which he adds a careful study of three operated in Mikulicz' clinic and from which, with this acknowledgement, I shall quote freely. If, therefore, I presume to add two cases, with conclusions drawn from the literature, I may be pardoned; since we can only from a number of thus accumulated cases draw deductions of value, as a basis for future treatment of a disease the symptomatology of which is by no means yet clear and settled. Cysts of the pancreas are of varying types and have been given a variety of names, but an attempt should now be made to secure some definite classification. Arsène Bas,
A multicentre, open-label, randomised comparative study of tigecycline versus ceftriaxone sodium plus metronidazole for the treatment of hospitalised subjects with complicated intra-abdominal infections
Authors: Shirin Towfigh, Jacyr Pasternak, Andre Poirier, Heidi Leister, Tim Babinchak
Journal: Clinical Microbiology and Infection (2009)

<h2>Abstract</h2> Tigecycline (TGC) has demonstrated clinical efficacy and safety, in comparison with imipenem/cilastatin in phase 3 clinical trials, for complicated intra-abdominal infection (cIAI). The present study comprised a multicentre, open-label, randomized study of TGC vs. ceftriaxone plus metronidazole (CTX/MET) for the treatment of patients with cIAI. Eligible subjects were randomized (1:1) to receive either an initial dose of TGC (100 mg) followed by 50 mg every 12 h or CTX (2 g once daily) plus MET (1–2 g daily), for 4–14 days. The primary endpoint was the clinical response in the clinically evaluable (CE) population at the test of cure (TOC) assessment. Of 473 randomized subjects, 376 were CE. Among these, clinical cure rates were 70.4% (133/189) with TGC vs. 74.3% (139/187) with CTX/MET (95% CI –13.1 to 5.1; p 0.009 for non-inferiority). Clinical cure rates for subjects with Acute Physiological and Chronic Health Evaluation II scores ≥10 were 56.8% (21/37) with TGC vs. 58.3% (21/36) with CTX/MET. The microbiologic response was similar between the two treatment arms, with microbiological eradication at TOC achieved in 68.1% (94/138) of TGC-treated subjects and 71.5% (98/137) of CTX/MET-treated subjects. (The most frequently reported adverse events (AEs) for both treatment arms were nausea (TGC, 38.6% vs CTX/MET, 27.7%) and vomiting (TGC, 23.3% vs CTX/MET, 17.7%). Overall discontinuation rates as a result of an AE were 8.9% and 4.8% in TGC- and comparator-treated subjects, respectively. The results obtaned in the present study demonstrate that TGC monotherapy is non-inferior to a combination regimen of CTX/MET with respect to treating subjects with cIAI.
CASE OF ACUTE VERONAL (BARBITAL) POISONING SIMULATING EPIDEMIC ("LETHARGIC") ENCEPHALITIS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prospective study of a family cancer syndrome
Authors: F. P. Li
Journal: JAMA (1982)

Risk of cancer was studied prospectively in four families described in 1969 as having diverse neoplasms, especially breast cancer and soft-tissue sarcoma. Between 1969 and 1981, in ten of 31 surviving family members, there developed 16 additional cancers (expected, 0.5). There were five breast carcinomas, four soft-tissue sarcomas, and seven other cancers. In eight patients, multiple primary cancers developed, including three softtissue sarcomas and one mesothelioma at sites of prior radiotherapy. (<i>JAMA</i>1982;247:2692-2694)
Uterine Chorionepithelioma
Authors: P. A. Trafford
Journal: BMJ (1953)

Saline suspensions of both samples were not agglutinated by one anti-C serum free from incomplete anti-D, five anti- E sera free from incomplete anti-D, five anti-c sera, three anti-e sera, one anti-Cw serum, and three samples of incomplete anti-D.Neither sample of red cells reacted with two incomplete anti-C sera free from incomplete anti-D (from Rh-positive donors).Neither sample reacted with the serum of the original -D-/-Dpatient, Mrs. B.: this serum had agglutinated all of more than 1,400 samples of Group 0 red cells, and was shown to contain anti-C, anti-c, and anti-e (Race, Sanger, and Selwyn, 1950, 1951).Saline suspensions of red cells of the original -D-/-D- patient, Mrs. B., had been agglutinated by 14 out of 16 incomplete anti-D sera.Dr. Philip Levine, of Ortho Research Foundation, has tested saline suspensions of the red cells of Mrs. V. W. against titrations of 13 incomplete anti-D sera; the results are shown in the Table; the cells were agglutinated by 11 of the 13 sera.The agglutination of these cells, however, is not directly related to the titre of incomplete anti-D, as is indicated by the striking differ- ences observed in the behaviour of the five sera of highest titre.Dr. Levine showed that the absence of C from the red cells of Mrs. V. W. could also be demonstrated with the aid of a complete anti-D + anti-C serum; he found that the anti-D component could be successfully blocked by the addition of selected incomplete anti-D (see Table ).Differences in Behaviour of Various Anti-D Sera.Tests b X
Screening for Colorectal Cancer: The Accuracy of Fecal Occult Blood
Authors: Graeme P. Young
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The recent article by Ahlquist et al<sup>1</sup>concludes that fecal occult blood tests (FOBTs) have little value in early detection of colorectal cancer. This sweeping claim seems unjustified for two reasons. The first is that FOBTs do not all test for the same analyte in stool specimens. Hemoglobin is degraded in feces to a range of different products, including free heme and heme-derived porphyrins (HDPs). Heme-derived porphyrins lack the peroxidase activity of heme on which guaiac tests depend. The HemoQuant test (Mayo Medical Laboratories, Rochester, Minn; and SmithKline Beecham, Van Nuys, Calif) measures heme (free or in hemoglobin, myoglobin, or certain cytochromes) and HDPs.<sup>2</sup>To claim, as Ahlquist et al do, that HemoQuant measures fecal hemoglobin is incorrect, as heme and HDPs are measured regardless of source and even when the globin moiety has been digested/degraded in the gut. As shown in this study and
Neonatal osteomyelitis due to Proteus mirabilis
Authors: H. L. Levy
Journal: JAMA (1967)

Proteus mirabilis osteomyelitis occurred in two neonates. The clinical symptoms and roentgenographic findings did not differ significantly from those seen in other forms of bacterial osteomyelitis in the newborn. Nursery contamination with the offending organism was not found, although the circumstances of multiple P mirabilis infections in a single nursery suggested this possibility. Antibiotic therapy consisted of potassium penicillin (G) and kanamycin sulfate in one case, and kanamycin and chloramphenicol sodium succinate in the other case. Both patients made uneventful recoveries.
LETTER FROM LONDON.
Authors: None G. O. M.
Journal: JAMA (1889)

(FROM OUR OWN CORRESPONDENT.) The Father Damien Memorial Meeting at the Mansion House—Picrotoxin as an Antidote to Morphine—Honors to Sir Andrew Clark—The Lord Mayor Inaugurates a Fund for the Pasteur Institute—A New Method of Disposing of the Dead—A New First Field Dressing—The New Commissioner in Lunacy—Consumption can be Transmitted to Human Beings through Milk. The first meeting of the committee for promoting a memorial of Father Damien has been held at Marlborough House, under the presidency of the Prince of Wales. The proposal is to erect a monument to the deceased missionary over his grave at Molokai, to establish a leper ward in one of the London hospitals, to endow one or two traveling studentships for the special study of leprosy, and finally to set on foot a full and exhaustive inquiry into the whole question of leprosy in India. It is calculated that there are in the Indian Empire
PBC focused study group
Journal: Hepatology (2003)

A human betaretrovirus resembling the mouse mammary tumor virus (MMTV) has been characterized in primary biliary cirrhosis (PBC) and associated with aberrant pyruvate dehydrogenase complex (PDC)–E2-like expression. As MMTV is prevalent in mice as either an exogenous or endogenous infection, we tested the hypothesis that MMTV is linked with anti-mitochondrial antibody (AMA) production in models with severe immune dysfunction.Evidence for MMTV was assessed in the liver and spleen of mice by PCR and immunochemistry and PDC-E2-like protein by immunochemistry. ELISA and Western blot were used to investigate AMA and anti-MMTV antibody production.Increased MMTV gag or env expression was detected in the livers of AMA producing mice including NOD.c3c4, CD4 directed dominant negative TGF-β receptor II and IL-2 receptor α knockout mice as well as the NOD parental strain when compared to healthy strains and biliary disease control mice. The NOD.c3c4 mice expressed MMTV surface and capsid proteins and aberrant PDC-E2-like protein in the bile ducts, whereas IL-2 receptor α knockout mice, NOD.c3c4 and the NOD mice expressed MMTV proteins and aberrant PDC-E2-like protein in the spleen. A significant correlation between anti-MMTV antibody production and AMA production was observed in the sera of NOD and NOD.c3c4 mice (p <0.0001).The association of betaretroviral protein production and aberrant PDC-E2-like protein expression in the NOD.c3c4, NOD, and the IL-2 receptor α knockout mice is comparable to observations in patients with PBC. The correlation of AMA and anti-MMTV suggests the hypothesis that MMTV infection may trigger the production of AMA.