tbuckley/cabot-search huggingface dataset:
Management of ventricular tachyarrhythmias. Part I
Authors: M. Akhtar
Journal: JAMA (1982)

VENTRICULAR tachyarrhythmias represent a substantial management problem in clinical practice, frequently posing a diagnostic and therapeutic dilemma in critical, often life-threatening circumstances. In this article, the current concepts and approaches to the management of ventricular arrhythmias will be addressed. Traditionally, ventricular arrhythmias are defined as abnormal impulses originating from areas below the division of the His bundle and may take the form of isolated ventricular premature beats (VPBs) or be more sustained. A ventricular rhythm lasting for three or more complexes with a rate of 100 to 250/min is called ventricular tachycardia (VT). Although hemodynamic deterioration frequently results, an organized and effective ventricular contraction pattern is usually maintained during VT unless the rates are exceedingly fast. When ventricular activation is rapid and chaotic, it is referred to as ventricular fibrillation (VF), the hemodynamic consequences of which are catastrophic, and is therefore considered to be the most malignant of all ventricular
Expression of tetra-spans transmembrane family (CD9, CD37, CD53, CD63, CD81 and CD82) in normal and neoplastic human keratinocytes: an association of CD9 with α3β1 integrin
Authors: H. OKOCHI, M. KATO, K. NASHIRO, O. YOSHIE, K. MIYAZONO, M. FURUE
Journal: British Journal of Dermatology (1997)
Haemophilus parainfluenzae meningitis in a newborn
Authors: E. H. Gullekson
Journal: JAMA (1966)

ALTHOUGH<i>Haemophilus influenzae</i>meningitis has been described in newborns, a search of the literature failed to reveal a case of H<i>parainfluenzae</i>meningitis in a newborn. <h3>Report of a Case</h3> A full-term baby was delivered on March 21, 1963. The membranes had not ruptured prematurely, and the total duration of labor was five hours. The newborn appeared normal during the first 48 hours. On March 23, the baby's temperature was recorded as 101.8 F (38.8 C) rectally. At that time, twitching of the eyes was noted. The color of the skin was dusky. The anterior fontanelle bulged at rest. Except for a few rales in the left side of the chest, the results of the rest of the examination were within normal limits. Spinal fluid, taken on the same day, was red-brown in color, had a leukocyte count of 1,440/cu mm, with 56% neutrophils and 44% mononuclear cells, and 8,570
The Year-book of Treatment for 1898. A Critical review for Practitioners of Medicine and Surgery.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Burn units as a source of methicillin-resistant Staphylococcus aureus infections
Authors: J. M. Boyce
Journal: JAMA (1983)

During a 3 1/2-year period (January 1978 through June 1981), 245 patients in a university hospital became colonized or infected with methicillin-resistant<i>Staphylococcus aureus</i>. During the first 18 months, the incidence of colonization and infection was only 0.05%. After a focal outbreak of methicillin-resistant<i>S aureus</i>in the burn unit, acquisition of the organism by patients on other wards increased significantly. Nonburn patients acquired the organism more often during time periods when newly admitted burn patients acquired methicillin-resistant<i>S aureus</i>. After the burn unit was closed, acquisition of the organism among nonburn patients on adult surgical and medical services decreased significantly. A questionnaire survey of other institutions disclosed that large outbreaks of this infection occurred more frequently in hospitals with burn units. These studies suggest that the occurrence of methicillin-resistant<i>S aureus</i>infections in burn units may lead to increased transmission of the organism to nonburn patients and that control of the infection in such units may reduce spread of the organism to patients without burns. (<i>JAMA</i>1983;249:2803-2807)
A Manual of Instruction in the Principles of Prompt Aid to the Injured,
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recovery From Drug Dependence
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An open label phase 1/2A study to evaluate the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of TRC253, an androgen receptor antagonist, in patients with metastatic castration-resistant prostate cancer.
Authors: Dana E. Rathkopf, Mansoor N. Saleh, Frank Yung-Chin Tsai, Mehmet Asim Bilen, Lee S. Rosen, Marco Gottardis, Jeffrey R. Infante, Bonne J. Adams, Lilian Liu, Charles P. Theuer, James L. Freddo, Neeraj Agarwal
Journal: Journal of Clinical Oncology (2019)

e16542 Background: TRC253 is a high-affinity, orally active small molecule antagonist of the androgen receptor (AR) and specific mutated variants of AR that does not possess agonist activity towards either wild type or mutated AR. TRC253 inhibits AR nuclear translocation as well as AR binding to DNA and is a transcription antagonist. TRC253 treatment is efficacious in an LNCaP xenograft model driven by F877L mutant AR. Methods: In P1 dose escalation, pts with mCRPC previously treated with an AR inhibitor were assigned to increasing TRC253 doses of 40-320 mg daily. Dose escalation followed single-pt dose escalation design for the 40, 80 mg cohorts and expanded to 3+3 design in the 160, 240, 280, and 320 mg cohorts to assess safety, determine the recommended phase 2 dose (RP2D), and evaluate prostate-specific antigen response at week 12. Toxicity and efficacy assessments used NCI-CTCAE v4.03 and PCWG3 criteria, respectively. Pts were centrally screened by circulating tumor DNA using the BEAMing digital PCR assay. Results: Twenty-two pts were enrolled in phase 1 at TRC253 doses of 40 (n = 1), 80 (n = 1), 160 (n = 2), 240 (n = 6), 280 (n = 4), and 320 mg (n = 8) daily in 28-day cycles. One DLT of G3 QTcF prolongation occurred at 320 mg. No drug-related SAEs were reported. Drug-related AEs ≥ G2 included QTcF prolongation (2 G2, 2 G3), elevated lipase (1 G3), fatigue (4 G2), arthralgia (1 G2), diarrhea (1 G2), and platelet count decrease (1 G2). One pt on study had AR F877L at baseline and remained on treatment for 49 wks with PR by RECIST. The remaining 21 pts did not have AR F877L at baseline and of these, 48% (10) remained on study &gt; 6 cycles and one pts had a &gt; 50% decrease in PSA. Target PK exposures were achieved consistently at 280 mg. 280 mg was selected as the RP2D based on safety and PK data. Conclusions: TRC253 daily at 280 mg was well-tolerated and selected as the RP2D. P2 dose expansion is currently enrolling 2 cohorts: 15 pts with AR F877L and 30 pts without AR F877L. The objectives of P2 include collection of additional data for safety, PK, PET and efficacy of TRC253 in mCRPC pts with specific AR mutations. Clinical trial information: NCT02987829.
The Psychology of Childhood.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Tonuskrankheiten des Herzens und der Gefässe: Ihre Biologie und Therapie
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholecystohepatic connections in a case of extrahepatic biliary atresia. A 27-year follow-up
Authors: G. R. Schorlemmer
Journal: JAMA (1984)

EXTRAHEPATIC biliary atresia is an infrequent entity that presents a variety of clinical features. Although the pathogenesis remains the subject of some debate, it is thought to begin in utero and may continue after birth, resulting in the segmental or total obliteration of the intrahepatic and/ or extrahepatic biliary system.<sup>1</sup>Clinical experience would suggest that surgical intervention in some manner interrupts this progressive process, particularly in the "noncorrectable" forms. The patient described herein is illustrative and presents anatomic variations not previously described, to the best of our knowledge. Longterm survival is attributed to cholecystohepatic channels. <h3>Report of a Case</h3> A 5-year-old girl was seen in 1956 because of slow development and at least three episodes of jaundice, attributed to "infectious hepatitis," first described at 3 years of age. At operation in 1956 for a suspected congenital deformity, the gallbladder was noted to be large, thick walled, distended, and moderately
Orthopedic Pathology
Authors: Hue H. Luu
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicine. Volumes I and II
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sidestream Tobacco Smoke Exposure Acutely Alters Human Nasal Mucociliary Clearance
Authors: Rebecca Bascom, Jana Kesavanathan, Thomas K. Fitzgerald, Kuo-Hsi Cheng, David L. Swift
Journal: Environmental Health Perspectives (1995)

Nasal mucociliary clearance (NMC) is a biomarker of nasal mucosal function. Tobacco smokers have been shown to have abnormal NMC, but the acute effect of environmental tobacco smoke (ETS) on nonsmokers is unknown. This study evaluated acute tobacco smoke-induced alterations in NMC in 12 healthy adults. Subjects were studied on 2 days, separated by at least 1 week. Subjects underwent a 60-min controlled exposure at rest to air or sidestream tobacco smoke (SS) (15 ppm CO) in a controlled environmental chamber. One hour after the exposure, 99mTc-sulfur colloid was aerosolized throughout the nasal passage and counts were measured with a scintillation detector. Six out of 12 subjects showed more rapid clearance after smoke exposure than after air exposure, and 3/12 had rapid clearance on both days. However, substantial decreases in clearance occurred in 3/12 subjects, all of whom had a history of ETS rhinitis. In two subjects, more than 90% of the tracer remained 1 hr after tracer administration (2 hr after smoke exposure). Understanding the basis for biologic variability in the acute effect of tobacco smoke on NMC may advance our understanding of pathogenesis of chronic effects of ETS.
Vaccination of MSI-H colorectal cancer patients with frameshift peptide antigens: A phase I/IIa clinical trial.
Authors: Matthias Kloor, Miriam Reuschenbach, Julia Karbach, Mohammed Rafiyan, Salah-Eddin Al-Batran, Claudia Pauligk, Elke Jaeger, Magnus von Knebel Doeberitz
Journal: Journal of Clinical Oncology (2015)

3020 Background: High level microsatellite instability (MSI-H) occurs in 15% of colorectal cancers as a consequence of DNA mismatch repair deficiency. MSI-H colorectal cancers are characterized by a dense immune cell infiltration. They are characteristic of the inherited HNPCC (hereditary non-polyposis colorectal cancer) or Lynch syndrome, but can also develop sporadically. DNA mismatch repair deficiency causes insertion or deletion mutations at coding microsatellites, which leads to the generation of frameshift peptide (FSP) antigens. FSP antigens are attractive targets for vaccination, because they are highly immunogenic shared antigens, which directly result from driver mutations in MSI-H cancers. To evaluate safety and immunological efficacy of FSP vaccination, we have initiated a clinical phase I/IIa vaccination trial (Micoryx). Methods: The protocol comprised 3 cycles of 4 subcutaneous applications of FSP antigens (frameshift variants of the coding microsatellite-containing genes AIM2, HT001, TAF1B) mixed with Montanide ISA-51 VG over a 6 month period. Inclusion criteria were history of colorectal cancer (UICC stage III or IV) who received standard chemotherapy. Phase I of the trial evaluated safety and toxicity as the primary endpoint (6 patients), phase IIa addressed the induction of cellular and humoral immune responses (16 patients). Results: No FSP antigen-associated severe adverse events have been observed. Significant induction of FSP-specific immune responses against one or more FSP antigens was observed in all patients vaccinated per protocol. Few patients had stage IV disease and were evaluable according to RECIST. One heavily pretreated patient with bulky metastases showed a stable disease and stable CEA levels over 7 months under the study treatment. Conclusions: Vaccination with FSPs is well tolerated and leads to the induction of humoral and cellular immune responses. FSP vaccination represents a promising novel approach for treatment of MSI-H colorectal cancer patients and for tumor prevention in Lynch syndrome, allowing the evaluation of the concept of preventive cancer vaccines in an ideal model scenario of a defined high-risk patient population. Clinical trial information: NCT01461148.
Workshop on Guinea Pig L2C Leukemia
Journal: JNCI Journal of the National Cancer Institute (1976)

Workshop on Guinea Pig L2C Leukemia Get access JNCI: Journal of the National Cancer Institute, Volume 57, Issue 3, September 1976, Page 737, https://doi.org/10.1093/jnci/57.3.737 Published: 01 September 1976
GLANDULAR THERAPY
Authors: W. A. Puckner
Journal: JAMA (1927)

The following articles were prepared under the direction of the Council on Pharmacy and Chemistry for inclusion in a new edition of the series of articles on glandular therapy which was published inThe Journal, Sept. 27, to Dec. 20, 1924. The article by Collip, "The Calcium Mobilizing Hormone of the Parathyroid Glands," takes the place of an article by McCallum, on whose recommendation Collip was asked to prepare it. The article by McCann, "Parathyroid Therapy," was written to replace the author's former article in the series. These articles are designed to bring the section on parathyroid therapy up to date. In addition to the articles by Collip and McCann, the article "Simple Goiter and Its Prevention" (The Journal, Oct. 30, 1926, p. 1463) by David Marine was also written for inclusion in the series. Other articles in the series have been subjected to critical revision in order to