tbuckley/cabot-search huggingface dataset:
Vaccinia-Based Immunization May Be On the Way
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mutant huntingtin impairs Ku70-mediated DNA repair
Authors: Yasushi Enokido, Takuya Tamura, Hikaru Ito, Anup Arumughan, Akihiko Komuro, Hiroki Shiwaku, Masaki Sone, Raphaele Foulle, Hirohide Sawada, Hiroshi Ishiguro, Tetsuya Ono, Miho Murata, Ichiro Kanazawa, Nikolai Tomilin, Kazuhiko Tagawa, Erich E. Wanker, Hitoshi Okazawa
Journal: The Journal of Experimental Medicine (2010)
Combined estrogen and progestin hormone replacement therapy in relation to risk of breast cancer in middle-aged women
Authors: J. L. Stanford
Journal: JAMA (1995)

<h3>Objective.</h3> —To determine the risk of breast cancer in relation to the use of combined estrogen and progestin hormone replacement therapy (HRT). <h3>Design.</h3> —A population-based case-control study. <h3>Setting.</h3> —The general female population of King County in western Washington State. <h3>Participants.</h3> —Middle-aged (50 to 64 years) women, including 537 patients with incident primary breast cancer diagnosed between January 1,1988, and June 30, 1990, who were ascertained through the Seattle—Puget Sound Surveillance, Epidemiology, and End Results cancer registry and 492 randomly selected control women without a history of breast cancer. <h3>Main Outcome Measure.</h3> —Breast cancer risk in relation to use of menopausal hormones. <h3>Results.</h3> —Menopausal hormones of some type had been used by 57.6% of breast cancer cases and 61.0% of comparison women. The women who had ever taken combined estrogen-progestin HRT, representing 21.5% of cases and 21.3% of controls, were not at increased risk of breast cancer (relative odds [RO]=0.9; 95% confidence interval [CI], 0.7 to 1.3). Compared with nonusers of menopausal hormones, those who used estrogen-progestin HRT for 8 or more years had, if anything, a reduced risk of breast cancer (RO=0.4; 95% CI, 0.2 to 1.0). <h3>Conclusions.</h3> —On the whole, the use of estrogen with progestin HRT does not appear to be associated with an increased risk of breast cancer in middle-aged women. Nonetheless, since the use of combined estrogen-progestin HRT has only recently become prevalent, future investigations must assess whether breast cancer incidence is altered many years after estrogen-progestin HRT has been initiated, particularly among long-term users. (<i>JAMA</i>. 1995;274:137-142)
The bone marrow pool of megakaryocytes and their ability to proliferate are preserved in rats with advanced cirrhosis
Authors: Iris Asensio, Carolina Franco, Jose Ignacio Fortea, Elena Vázquez-Ogando, Marta Puerto, Carolina Fernández-Mena, Johanna Sierra, Christian Ruiz, Cristina Ripoll, Rafael Bañares, Javier Vaquero
Journal: Journal of Hepatology (2020)
The effect of overlapped $beta;-emitter by manual stepping for diffuse in-stent restenosis lesions: Angiographic and IVUS analysis Han-Soo Kim, Ron Waksman, Balram Bhargava, Chrysoula K. Pappas, Andrew E. Ajani, Rosanna C. Chan, Anh B. Bui, R. Lawrence White, Lowell F. Satler, Augusto D. Pichard, Gary S. Mintz, Petros Okubagzi, Michael Porrazzo, Kenneth M. Kent. Washington Hospital Center, Washington, DC
Journal: Journal of the American College of Cardiology (2001)
Acne mechanica.
Journal: BMJ (1976)

Acne mechanicaMost patients with acne have classical adolescent acne, but some have unusual types such as infantile' or cosmetic acne.2We record here another unusual, although not uncommon, type associated with mechanical stress on the skin or abnormal posture.These patients who probably fit into the recently described group acne mechanica3 are more likely to present in the first instance to the family practitioner, or orthopaedic or dental surgeon.
American Journal of Ophthalmology, Chicago
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk factors for lack of detectable antibody following hepatitis B vaccination of Minnesota health care workers
Authors: R. C. Wood
Journal: JAMA (1993)

<h3>Objective.</h3> —To assess the presence of antibody to hepatitis B surface antigen (anti-HBs) at postvaccination testing in Minnesota health care workers receiving recombinant hepatitis B vaccines, and to identify risk factors for lacking anti-HBs following hepatitis B vaccination. <h3>Design.</h3> —Retrospective cohort study. <h3>Setting.</h3> —Ten acute care hospitals in Minnesota. <h3>Participants.</h3> —A total of 595 health care workers who had received hepatitis B vaccine (Recombivax HB or Engerix-B) between June 1987 and December 1991 and who underwent postvaccination testing for anti-HBs within 6 months after receiving the third dose of vaccine. <h3>Main Outcome Measure.</h3> —Presence or absence of anti-HBs following hepatitis B vaccination. <h3>Results.</h3> —Five variables were independently associated with lacking anti-HBs by multivariate analysis: vaccine brand, smoking status, gender, age, and body mass index. Stratifying by vaccine brand demonstrated that age (<i>P</i>=.01), body mass index (<i>P</i>&lt;.01), and smoking status (<i>P</i>&lt;.01) were associated with lacking anti-HBs only for Recombivax HB recipients; and gender (<i>P</i>=.03) was associated with lacking anti-HBs only for Engerix-B recipients. After controlling for smoking status, age, gender, and body mass index, recipients of Recombivax HB were more likely to lack anti-HBs than recipients of Engerix-B (relative risk, 2.3; 95% confidence interval, 1.1 to 4.7;<i>P</i>=.02). <h3>Conclusions.</h3> —Results indicate that certain populations of health care workers are at increased risk of not responding to hepatitis B vaccination. Further studies evaluating immunogenicity of currently available recombinant hepatitis B vaccines in persons at high risk for primary vaccine failure are needed. (<i>JAMA</i>. 1993;270:2935-2939)
In This Issue
Journal: Journal of Clinical Investigation (2006)

PCSK9 works on the outside to bring down LDLR levelsIndividuals with a gain-of-function mutation in one of their genes encoding the serine protease proprotein convertase subtilisin/ kexin type 9 (PCSK9) are hypercholesterolemic.Although known to be caused by PCSK9-mediated decrease in the number of LDL receptors (LDLRs) expressed by hepatocytes, the precise mechanisms by which PCSK9 engenders hypercholesterolemia have not been previously determined.Here, Lagace and colleagues show that exogenous PCSK9 decreases the number of LDLRs expressed at the cell surface of human hepatoma cells (pages 2995-3005).This decrease occurred when exogenous PCSK9 bound cell-surface LDLRs, initiating PCSK9 and LDLR internalization to the late endocytic compartment.Importantly, results of further studies using mice overexpressing PCSK9 indicated that PCSK9 secreted into the plasma decreased the cell-surface expression of LDLR by the hepatocytes of wild-type parabiotic partners.This decrease was concomitant with an increase in plasma LDL-cholesterol concentrations.These findings indicate that PCSK9 secreted into the plasma regulates the level of LDLR expression by hepatocytes.The authors suggest that blocking PCSK9 function in the plasma might provide a new approach for developing drugs to treat hypercholesterolemia.
Practice of Obstetrics.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LEGAL EFFECT OF ACCEPTING AN AMOUNT LESS THAN BILL RENDERED.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Desiderius Erasmus (1466-1536) the great humanist
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
F(x)
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inégalité Pupillaire et Tuberculose Pulmonaire.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The thyroid and the psychiatrist.
Journal: BMJ (1977)

cosmetic camouflage.James'5 suggests that intralesional injec- tions of corticosteroid and oral antimalarials are helpful, but this faith may be too optimistic.The use of antimalarials always causes anxiety about the eyes; peripheral neuritis may develop, as may occasionally such deep pigmentation of the lesions that they became much more difficult to hide.Besnier7 was impressed with the result of the galvanocautery: the patient's ears were cropped and the disease did not return.If there is so much swelling present that cosmetics are ineffective, then plastic surgery should, perhaps, be considered.Patience may be justified: though the lesions of chronic sarcoidosis often persist, eventual resolution is possible,"6 and Boeck's original patient was free of the disease at his death at the age of 80 from hypernephroma.' 7
AN ARMY MEDICAL BOARD.
Journal: JAMA (1892)

In response to our suggestion in a recent issue ofThe Journal, the Surgeon-General of the United States Army issues the following notice. We earnestly hope the Surgeon-General of the Navy and Marine-Hospital Service will also see the propriety of convening examining boards in other interior cities. This is as it should be. AN ARMY MEDICAL BOARD will be in session in Chicago, Ill., during February, 1892, for the examination of candidates for appointment in the Medical Corps of the United States Army, to fill existing vacancies. Persons desiring to present themselves for examination by the Board will make application to the Secretary of War, before January 15, 1892, for the necessary invitation, stating the date and place of birth, the place and State of permanent residence, the fact of American citizenship, the name of the medical college from whence they were graduated, and a record of service in hospital,
Idiopathic Hypercalcuria
Authors: Philip H. Henneman, Patricia H. Benedict, Anne P. Forbes, H. Robert Dudley
Journal: New England Journal of Medicine (1958)

THE 35 male¶ patients described below illustrate a syndrome characterized by a normal serum calcium level, a low serum phosphorus level and an increased urinary calcium excretion. This dislocation of homeostasis has been brought to our attention in the Kidney Stone Clinic because of associated kidney stones.Hypercalcuria, as emphasized by Flocks,1 is frequently found in patients with kidney stones. There are many causes of hypercalcuria: hyperparathyroidism; osteoporosis, while the disease is progressing; Cushing's syndrome and during high-dosage ACTH and corticoid therapy; high intake of calcium and administration of vitamin D; sarcoidosis and beryllium poisoning; certain forms of osteomalacia of . . .
EPIDEMIOPHOBIA.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bioassay of Metals for Carcinogenesis: Whole Animals
Authors: Arthur Furst
Journal: Environmental Health Perspectives (1981)

Metals have been evaluated as potential carcinogens by administering pure elements or compounds by a large variety of routes. These include mixing the agent in the food, dissolving the test compound in the drinking water, or administering the material by gavage. The respiratory tract routes tested include inhalation, intratracheal instillation, the direct injection of particulates into the pleural cavity, or the implantation of hooks by surgical intervention. The parenteral routes used were intravenous injection, intraperitoneal injection, subcutaneous implantation, as well as intrafemoral and intramuscular injection. This latter route is the most commonly used. There are major objections to the subcutaneous implantations route, and data generated from these experiments are difficult to interpret for the foreign body reaction may give rise also to fibrosarcomas. This then is a nonspecific reaction. Exotic routes tested include intrarenal, intratesticular, and intracranial injections. The endpoints of the carcinogenic reactions are, in the main, sarcomas of certain types with fibrosarcomas predominating. Rhabdomyosarcomas are the next most frequent cancer found, and squamous cell carcinoma may account for less than 2% of the cancers reported. Much more research is necessary to clarify the nature of metal carcinogenesis. Dose-response information is almost nonexistent; the divided dose problem has not been studied adequately, and very little information is available on interspecies reactions. More work is needed to help interpret the mechanism of action.
Palliation of malignant obstructive jaundice-surgery or stent?
Authors: P. B Cotton
Journal: Gut (1991)

<h3>Background</h3> Anatomic abnormalities increase the risk of deceased donor kidney discard, but their effect on transplant outcomes is understudied. We sought to determine the effect of multiple donor renal arteries on early outcomes after deceased donor kidney transplantation. <h3>Methods</h3> For this retrospective cohort study, we identified 1443 kidneys from 832 deceased donors with ≥1 kidney transplanted at our center (2006–2016). We compared the odds of delayed graft function and 90-day graft failure using logistic regression. To reduce potential selection bias, we then repeated the analysis using a paired-kidney cohort, including kidney pairs from 162 donors with one single-artery kidney and one multiartery kidney. <h3>Results</h3> Of 1443 kidneys included, 319 (22%) had multiple arteries. Multiartery kidneys experienced longer cold ischemia time, but other characteristics were similar between groups. Delayed graft function (50% multiartery versus 45% one artery, <i>P</i>=0.07) and 90-day graft failure (3% versus 3%, <i>P</i>=0.83) were similar between groups before and after adjusting for donor and recipient characteristics. In the paired kidney analysis, cold ischemia time was significantly longer for multiartery kidneys compared with single-artery kidneys from the same donor (33.5 versus 26.1 hours, <i>P</i>&lt;0.001), but delayed graft function and 90-day graft failure were again similar between groups. <h3>Conclusions</h3> Compared with single-artery deceased donor kidneys, those with multiple renal arteries are harder to place, but experience similar delayed graft function and early graft failure.