tbuckley/cabot-search huggingface dataset:
Subchronic Inhalation Toxicology of Ethylene Glycol Monoethyl Ether in the Rat and Rabbit
Authors: Steven J. Barbee, James B. Terrill, David J. DeSousa, C. Clifford Conaway
Journal: Environmental Health Perspectives (1984)

The subchronic inhalation toxicology of ethylene glycol monoethyl ether (EGEE) was evaluated in rats and rabbits using a 13-week exposure regimen. Groups of 20 rabbits (10 M, 10 F) and 30 rats (15 M, 15 F) were exposed to a vapor of 25 ppm, 100 ppm, or 400 ppm, 6 hr/day, 5 days/week. The control groups received air only. Physical examinations and body weight measurements were conducted on all animals pretest and weekly throughout the study. Ophthalmoscopic examination was performed pretest and at termination. Evaluation of hematology and clinical chemistry was conducted on 10 animals per sex per group from each species after 13 weeks of study. Histopathological changes were assessed for all animals from the high-dose and control groups. In addition, selected tissues were examined from all animals from the mid- and low-dose groups. Both species exhibited an increased incidence of lacrimation and mucoid nasal discharge, but the response was not consistently dose-related. Rats exposed to EGEE showed no compound-related effects except for a decrease in pituitary to body weight ratio for high-dose males and a decrease in absolute spleen weight for all female animals. The spleen to body weight ratio was also less than controls for the females in the low- and high-dose groups. Pathological changes supportive of these organ weight changes were not observed. The rabbit is the more sensitive species to the subchronic toxicological effects from EGEE. Mean body weight values for low- and high-dose animals were decreased; the mid-dose animals, however, showed no change.(ABSTRACT TRUNCATED AT 250 WORDS)
Analytical Approaches to the Study of the Disposition of Myelotoxic Agents
Authors: Douglas E. Rickert, Terrie S. Baker, John P. Chism
Journal: Environmental Health Perspectives (1981)

A correlation of myelotoxic effect with concentration or a foreign compound of its metabolite at the site of action may provide useful insights into the mechanism of toxic action and/or its amelioration. This correlation requires sensitive and specific assay methods. This communication describes useful methods for the study of benzene disposition in rodents. The assays are sensitive, specific, and rapid. They rely on gas chromatography-mass spectrometry and on high performance liquid chromatography. These methods have allowed measurement of catechol, phenol, and hydroquinone in samples of rodent bone marrow following inhalation exposure to benzene. Their application to the study of benzene metabolism in rat bone marrow in situ is also described.
Deloading of the Left Ventricle by Ventricular Assist Device Normalizes Increased Expression of Endothelin ET <sub>A</sub> Receptors But Not Endothelin-Converting Enzyme-1 in Patients With End-Stage Heart Failure
Authors: Henning Morawietz, Marten Szibor, Winfried Goettsch, Babett Bartling, Matthias Barton, Sidney Shaw, Reiner Koerfer, Hans-Reinhard Zerkowski, Juergen Holtz
Journal: Circulation (2000)

Background —Ventricular assist devices (VAD) are implanted in patients with end-stage heart failure for bridging the time until heart transplantation, resulting in hemodynamic unloading of the failing heart, improved cardiac contractile and mitochondrial function, and reversal of cardiac hypertrophy. It is unknown whether VAD unloading may affect the cardiac endothelin (ET) system, which has been proposed as one of the putative pathomechanisms of heart failure. Methods and Results —With the use of standard-calibrated, competitive reverse-transcription–polymerase chain reaction mRNA expression of components of the ET system was analyzed in left ventricular myocardium from nonfailing donor hearts, from failing hearts without and with ACE inhibitor therapy, and from patients with end-stage heart failure at the time of VAD implantation and 103±15 days after VAD implantation during removal with subsequent heart transplantation. ET receptor A (ET A ) was markedly upregulated in failing human myocardium. This increased ET A expression was not affected by ACE inhibitor treatment but was normalized by VAD unloading. ET A expression before or after VAD implantation did not correlate with duration of VAD implantation or suppression of Pro-ANP mRNA. ET B mRNA expression was unaffected by heart failure or VAD. In contrast, increased ET-converting enzyme-1 mRNA and ET-1 peptide levels in failing myocardium were partially normalized by ACE inhibition but not by VAD unloading. Conclusions —We conclude that VAD implantation normalizes ET A expression in failing human left ventricular myocardium, probably as the result of the beneficial effects of VAD unloading.
<i>Erratum:</i>Vol. 65, No. SS-6
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In the Surveillance Summary, "Youth Risk Behavior Surveillance - United States, 2015," an error occurred on page 27. In the second paragraph under "Condom Use," the first sentence should read as follows: "During 1991-2015, a significant linear increase occurred overall in the prevalence of having used a condom during last sexual intercourse (46.2%-56.9%)."
Methyl Methacrylate
Authors: Nicholas L. Schenck
Journal: JAMA (1976)

<h3>To the Editor.—</h3> "Hazard of Methyl Methacrylate to Operating Room Personnel" (235:2652,1976) focused on the problem of allergenic sensitization. In a recent investigation to find a suitable alternative material for frontal cranioplasty, we had the occasion to review other potential disadvantages of this widely used alloplastic material.<sup>1</sup> First, it is difficult to handle in the operating theater because of heat produced during the exothermic mixing process. Second, malleability is absent after it sets. Third, most surgeons are loathe to place the acrylic at a primary procedure because of potential infection, necessitating a temporary cosmetic deformity and a subsequent trip to surgery for eventual reconstruction. Fourth, the plastic implant is vulnerable to trauma with resulting fragmentation and, in certain cases, brain injury.<sup>2</sup>Cranioplast can also diffuse through intact surgical rubber gloves and cause contact dermatitis.<sup>3</sup> Hence, methyl methacrylate, one of the most valuable and widely used alloplastic surgical
Irrigated sump tube drainage following open-heart surgery
Authors: S. Gianelli
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Following openheart surgery, relatively small amounts of clots around the heart may critically impair cardiac function, even when the pericardium is left widely open. In a satisfactory system of thoracic drainage the drainage tubes should be located where blood is likely to accumulate, and the tubes should remain patent. During the past 18 months, in over 150 cases, we have employed a system which appears to meet these criteria. All our patients are operated on through a median sternotomy. The pleural cavities are not entered until bypass is completed. Then a wide communication is made between the pericardial sac and the right pleural space, extending posteriorly to within several millimeters of the phrenic nerve. The pericardium is left open in the midline from the diaphragm to the reflection over the aorta. The right pleural space is drained by a large sump tube in the posterior gutter. A
New Face Gives New Outlook? Not Always Says Psychiatrist
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patterns of Failure Following Local Excision and Local Excision and Postoperative Radiation Therapy for Invasive Rectal Adenocarcinoma
Authors: Christopher G. Willett, Joel E. Tepper, Susan Donnelly, William C. Wood, Paul C. Shellito, Grant V. Rodkey, Michael A. Stracher, Carolyn C. Compton
Journal: Journal of Clinical Oncology (1989)

An error was made in the running head of the report "Patterns of Failure Following Local Excision and Local Excision and Postoperative Radiation Therapy for Invasive Rectal Adenocarcinoma" by Willett et al in the August issue (J Clin Oncol 7:1003–1008, 1989). The running head should have read: "Local Excision and Radiotherapy for Rectal Cancer."
Cancer Sweepstakes
Authors: J. LOUGH
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Cancer Sweepstakes Get access JOHN LOUGH JOHN LOUGH Vice President for Public Affairs American Institute for Cancer Research1750 R Street, NW, Washington, DC 20009 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 6, 15 March 1989, Page 459, https://doi.org/10.1093/jnci/81.6.459 Published: 15 March 1989
American Journal of Cardiology, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABSTRACTS
Journal: Circulation (1955)

The authors studied in anesthetized dogs the effect on intravenous injection of 40 to 80 mg.Tromexan upon blood flow through the right coro- nary artery, the arterial and venous coronary pres- sure and oxygen consumption of the heart.In ad- dition, the cardiac output and the blood flow through the femoral artery or femoral vein were recorded.The results were as follows: Coronary blood flow increased whereas arterial and venous pressure and cardiac output remained unchanged.The total oxygen consumption of the heart declined slightly, the arterial oxygen desaturation was unchanged
REVISION OF ESSENTIALS OF AN APPROVED INTERNSHIP
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Monoclonal antibodies: clinical potential of a growth industry
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Matthew J. Stiller
Journal: Journal of the American Academy of Dermatology (1994)

tion, and the president of an organization of commercial concerns.U'P Letters from physicians and a clinical pharmacist regarding this article strongly supported the conclusions of Wilkes et al. [14][15][16] Dermatologists and their patients rely on pharmaceutical manufacturers to supply accurate scientific information.The vast majority of advertisements in the JOURNAL concern established drugs, not dramatic breakthroughs in medicine.Our unbiased article documented current and past medical advertising in the JOURNAL.Mr. Angel and his group believe that these findings "malign" medical advertising.The findings of our study do support the need to improve the educational value of medical advertisements.
Review: Azathioprine, infliximab, certolizumab, and adalimumab are effective for maintaining remission in Crohn disease
Authors: John K. Marshall
Journal: Annals of Internal Medicine (2008)

ACP Journal Club17 June 2008Review: Azathioprine, infliximab, certolizumab, and adalimumab are effective for maintaining remission in Crohn diseaseJohn K. Marshall, MD, MSc, FRCPC, AGAFJohn K. Marshall, MD, MSc, FRCPC, AGAFMcMaster University, Hamilton, Ontario, Canada (J.K.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-12-200806170-02009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationAkobeng AK. Review article: the evidence base for interventions used to maintain remission in Crohn's disease. Aliment Pharmacol Ther. 2008;27:11-8. https://pubmed.ncbi.nlm.nih.gov/17919275Clinical Impact RatingsGastroenterology: Reference1 D’Haens G, Baert F, van Assche G, et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet. 2008;371:660-7. [PMID: 18295023] Google Scholar Author, Article, and Disclosure InformationAffiliations: McMaster University, Hamilton, Ontario, Canada (J.K.M.)This article was published at Annals.org on 3 June 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 June 2008Volume 148, Issue 12Page: JC4-9KeywordsCrohn's diseaseFatty acidsLibrariesMethotrexateNutritionProbioticsSystematic reviews ePublished: 17 June 2008 Issue Published: 17 June 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Longevity of Samuel Bard
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Figure 2B Number at Risk Table
Authors: Mihnea Dragomir
Journal: JAMA Oncology (2019)

Feng Wang, MD, PhD; Qi Zhao, PhD; Ying-Nan Wang, MD, PhD; Ying Jin, MD, PhD; Ming-Ming He, MD, PhD; Ze-Xian Liu, MD, PhD; Rui-Hua Xu, MD, PhD
NEW DISCOVERIES ABOUT MALARIA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
9. Pharmacologic Approaches to Glycemic Treatment: <i>Standards of Medical Care in Diabetes—2020</i>
Journal: Diabetes Care (2019)

The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc20-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc20-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Nuclear threat: what about the Russians?
Authors: Sidney Alexander
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Your Aug 2 issue, which commemorates the 40th anniversary of the Hiroshima bombing, was superb. In particular, Paul Boyer's article was a gem. It should be required reading for all physicians interested in these important issues. The American Medical Association is to be congratulated for recognizing that the medical consequences of nuclear war, the psychologic factors that fuel the arms race, and diversion of funding from medical care to nuclear weapons research, development, and production are all properly within the professional interest and responsibility of physicians. I would like to comment on some of the points made by Day and Waitzkin<sup>1</sup>in their article, "The Medical Profession and Nuclear War." Their statement that the US leaders of the International Physicians for Prevention of Nuclear War (all of whom are also members of Physicians for Social Responsibility [PSR]) blame the United States chiefly for the arms race is
Electrophoresis Technique
Authors: Amoz I. Chernoff
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Dr. Barnes' article (<b>219</b>:701,1972), describes a method for preparing hemoglobin samples for electrophoresis without removing the stroma. A similar technique was described many years ago in connection with paper electrophoretic techniques. (<i>Amer J Clin Path</i><b>30</b>:120, 1958). Since the hemolyzing reagent was introduced directly into the capillary tube, the procedure was even simpler than that used by Barnes.
Reply
Authors: Naga Chalasani
Journal: Hepatology (2018)

Potential conflict of interest: Nothing to report. We thank Dr. Carey for his interest in our practice guidance document and his question about our recommendation not to use statins in patients with decompensated cirrhosis. We regret that because of space constraints, we did not provide our rationale for this recommendation. The concern with using statins in patients with decompensated cirrhosis is more to do with potentially increased areas under the curve for statins that are hepatically metabolized and the subsequent risk of extrahepatic organ toxicity, such as rhabdomyolysis. The case in point is the study by Abraldes et al., which investigated the role of simvastatin as an additive therapy for patients with cirrhosis after variceal bleeding.1 Although simvastatin did not reduce variceal bleeding, it showed survival advantage attributed to reasons that are not fully explained. However, 2 of 69 patients (∼3%) randomized to simvastatin developed symptomatic rhabdomyolysis (peak CPK levels were 7,823 and 3,500 U/L, respectively) and both patients had deteriorated liver function at baseline, with total bilirubin >5 mg/dL. We further alert Dr. Carey and other readers to the guidance provided by the National Lipid Association's Statin Liver Safety Task Force, which lists decompensated cirrhosis and acute liver failure as contraindications for statin therapy.2 However, statin therapy is safe in patients with compensated cirrhosis and thus we support their use in patients with cirrhosis who have dyslipidemia.