tbuckley/cabot-search huggingface dataset:
AMA's science reporters conference features good and bad medical news
Authors: A. A. Skolnick
Journal: JAMA (1995)

JOURNALISTS WHO gathered for the American Medical Association's 13th Annual Science Reporters Conference, held in Seattle, Wash, received both good and bad news about the health of the nation. The conference, which was cosponsored by the University of Washington School of Medicine, featured a diverse range of topics ranging from the new field of ecogenetics to sleep research in women at midlife to the noncontraceptive health benefits of oral contraceptives to acne's emotional toll on teenagers. The good news included reports of declining incidence rates of sexually transmitted diseases (STDs) and marked improvements in the safety of the nation's blood supply. Not so good were reports that physical activity levels among US high school students are declining and the cost of hospitalizing schizophrenic patients who discontinue their medication is soaring. <h3>Genes Interacting With Environment</h3> Researchers at the University of Washington School of Medicine have been pioneering a new field of
Uterine perforation by the IUD
Authors: P. A. McLeod
Journal: JAMA (1969)

<h3>To the Editor:—</h3> In addition to Jerome T. Siedlecki's reply to the question of emphysema in professional trumpet players, attention is directed to an item inForeign Letters(<i>JAMA</i><b>166</b>:1077, 1958). The study of Hävermark and Lundgren in which replies to a questionnaire were received from 364 musicians, glass blowers, and others, including 187 "blowers of various musical instruments," demonstrated clearly that no support could be found for the teaching that emphysema could be provoked by this kind of occupation.
Author Disclosures for Late-Breaking Abstracts
Authors: Frank Albers, Sarah Ashley, L9 Castro, Mario Gsk, L4 Mahajan, L26 Mansi, Marta Nothing, L13 Mathias, Vicki Mcwilliam, L18 Nothing, Lyndsey Muehling, L5 Nothing, Natalia Patterson, L16 Nothing, Rachel Peters, L29 Nothing, Charlene Prazma, L31 Windt
Journal: Journal of Allergy and Clinical Immunology (2015)
Cytokine-induced neutrophil chemoattractant release from hepatocytes is modulated by Kupffer cells
Authors: E Mawet
Journal: Hepatology (1996)

To clarify the role of intercellular communication in the liver during accumulation of neutrophils, the release of cytokine-induced neutrophil chemoattractant (CINC) (interleukin-8 [IL-8] related protein in rodents) by hepatocytes was investigated in the presence of Kupffer cell-conditioned medium in vitro. Kupffer cells were prepared by perfusion of rat liver with collagenase followed by centrifugation on a metrizamide gradient and were cultured in the presence or absence of lipopolysacharide (LPS). The conditioned medium was collected after 24 hours, and rat hepatocytes were cultured in the presence or absence of Kupffer cell-conditioned medium. An amount of CINC in the culture supernatant was measured by western blotting analysis and enzyme-linked immunosorbent assay (ELISA), and expression of its messenger RNA (mRNA) was assessed by the polymerase chain reaction. LPS-stimulated Kupffer cell-conditioned medium enhanced an expression of CINC mRNA in hepatocytes and increased the production of CINC by hepatocytes. Enhanced production of CINC was not shown when the Kupffer cell-conditioned medium was pretreated with heat (56 degrees C, 30 minutes). The production of CINC by hepatocytes in the presence of the LPS-stimulated Kupffer cell-conditioned medium was reduced by an antibody against interleukin 1β (IL-1β), but not by antibodies against tumor necrosis factor α (TNF-α) or LPS. These results suggest that production of CINC by hepatocytes could be regulated by IL-1β released from Kupffer cells, leading to neutrophil accumulation during liver injury, because this protein is a strong chemoattractant for neutrophils.
Phospholipase D activation in hepatocyte growth factor-stimulated rat hepatocytes mediates the expressions of c-jun and c-fos: Involvement of protein tyrosine kinase, protein kinase C, and Ca2+
Authors: T Adachi, S Nakashima, S Saji, T Nakamura, Y Nozawa
Journal: Hepatology (1996)

Hepatocyte growth factor (HGF) activated phospholipase D (PLD) in primary–cultured rat hepatocytes, as assessed by the formation of phosphatidylbutanol (PBut), a specific and stable product of PLD activity in the presence of 0.3% butanol. PLD hydrolyzes phosphatidylcholine to choline and phosphatidic acid (PA), which is further metabolized to diacylglycerol (DG) by PA phosphohydrolase (PAP). In HGF–stimulated hepatocytes, butanol prevented the formation of PA and DG. A PAP inhibitor, propranolol, inhibited DG production with a reciprocal increase of PA, implying that PLD played a role in the formation of not only PA but DG. Inhibitors for protein kinase C (PKC), Ro31–8425, H–7, and calphostin C, reduced HGF–induced PLD activation. A protein tyrosine kinase (PTK) inhibitor, genistein but not its inactive analogue daidzein, inhibited PLD activation by HGF. Moreover, depletion of extracellular Ca2+ by omission of Ca2+ or by chelating residual Ca2+ with ethyleneglycol–bis(β–aminoethyl ether)– N,N ,N′,N′–tetraacetic acid (EGTA) abolished HGF–induced PLD activation. HGF, phorbol myristate acetate (PMA) and a DG analog, oleylacetylglycerol (OAG), activated the expression of c–jun and c–fos messenger RNAs (mRNAs). Ro31–8425, calphostin C, and genistein, which prevented HGF–induced PLD activation, inhibited induction of these immediate early genes. Butanol and propranolol at concentrations which effectively inhibited the formation of DG, suppressed HGF–induced expression of c– jun and c– fos mRNAs. However, HGF–induced mitogen–activated protein kinase (MAPK) activation was not affected by both butanol and propranolol. These results suggest that PTK, PKC, and Ca2+ regulate HGF–induced PLD activation, and that DG produced by PLD pathway may play a role in the induction of immediate early genes, which is activated in MAPK–independent manner, in rat hepatocytes.
Preoperative diagnosis of Meckel diverticulum. Agiographic and radionuclide studies in an adult
Authors: L. R. Muroff
Journal: JAMA (1974)

In a 26-year-old man with bleeding Meckel diverticulum, the combined use of mesenteric angiography and scintillation imaging established the diagnosis preoperatively. There was excellent correlation between the results of these studies and the histologic findings in the resected diverticulum. (<i>JAMA</i>229:1900-1902, 1974)
ANOTHER DEATH FROM CHLOROFORM
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nursing Home Placement, Day Care Use, and Cognitive Decline in Alzheimer’s Disease
Authors: Robert Wilson
Journal: American Journal of Psychiatry (2007)

Objective: People with Alzheimer's disease are often placed in a nursing home, sometimes after using adult day care services. How affected persons function during this potentially difficult transition is not well understood. The aim of this study was to examine the associations of day care use and nursing home placement with the rate of cognitive decline in Alzheimer's disease. Method: The participants were 432 older persons with Alzheimer's disease who were recruited from health care settings in the Chicago area. At baseline, they lived in the community and were using day care services a mean 1.7 days per week. At 6-month intervals for up to 4 years, they completed nine cognitive tests from which a composite measure of global cognition was derived. Results: On average, cognition declined at a gradually increasing rate during the study period. Nursing home placement was associated with a decrease in the level of cognition and an acceleration in the rate of cognitive decline. Day care use at baseline was not related to cognitive decline in initial analyses, but it interacted with nursing home placement such that higher level of day care use substantially reduced association of placement with accelerated cognitive decline. Education interacted with placement such that more schooling was associated with a greater increase in cognitive decline upon nursing home placement, but prior day care use also attenuated this association. Conclusions: Nursing home placement is associated with accelerated short-term cognitive decline in Alzheimer's disease. Prior experience in adult day care may lessen this association.
The association between early life lung function and wheezing during the first 2 yrs of life
Authors: S. Young, J. Arnott, P.T O′keeffe, P.N Le Souef, L.I Landau
Journal: European Respiratory Journal (2000)

Reports have suggested that certain infants are predisposed to wheezing in the first 2 yrs of life due to abnormal lung function, prior to the first wheezing illness. The authors investigated the association between infant lung function and wheeze during the first 2 yrs of life. A cohort of 253 infants was evaluated. Respiratory function assessment was performed at 1, 6, and 12 months of age. Parental history of asthma, atopy, and maternal antenatal smoking habits were recorded. An infant was identified as having wheezed on the basis of parental report and, where possible, physician diagnosis. One hundred and sixty infants (63%) had complete diary and questionnaire information on wheeze available for analysis. Of these: 79 infants (50%) had never wheezed (NW) during the first 2 yrs of life and 81 had reported wheeze (W) (50%). Of those with a report of wheeze, the distribution through the first 2 yrs of life was; 28 during the first year of life only (Y1), 21 in the second year of life only (Y2), and 32 wheezed in both the first and second years of life (Y1&amp;2). At the age of 1 month, prior to any lower respiratory illness, the W group had impaired lung function in comparison to the NW group. In Y1 infants, the neonatal lung function differences resolved by 12 months of age. In Y2 and Y1&amp;2 infants lung function differences persisted throughout the first year of life. Prevalence of parental asthma and maternal antenatal smoking was increased in the W group p=0.001, p=0.008, respectively), in comparison to the NW infants. Maternal antenatal smoking prevalence was increased in the Y2 and Y1&amp;2 infants in comparison to the NW group (p=0.04), (p=0.01), respectively. Wheezing during the first year of life is often a transient condition which improves with time. It appears to be related to early life reduced small airway calibre. Wheezing that begins or persists into the second year of life is usually associated with a different abnormality of the airways. Commencement or persistence of wheeze into the second year of life may be part of the clinical entity recognized as asthma.
Addendum
Authors: Heinz Rueddel, Marlies A.E. Marissen, Ingmar H.A. Franken, Peter Blanken, Wim van den Brink, Vincent M. Hendriks, Stefan Büchi, Hanspeter Mörgeli, Ulrich Schnyder, Josef Jenewein, Urs Hepp, Eveline Jina, Rachel Neuhaus, Jean-Claude Fauchère, Hans Ulrich Bucher, Tom Sensky, Christian H. Röder, Matthias Michal, G. Overbeck, Vincent G. van de Ven, David E.J. Linden, Giovanni Abbate-Daga, Secondo Fassino, Rossana Lo Giudice, Innocenzo Rainero, Carla Gramaglia, Lucrezia Marech, Federico Amianto, Salvatore Gentile, Lorenzo Pinessi, Franco Benazzi, Jürgen De Fruyt, Koen Demyttenaere, S. Nassir Ghaemi, Ross J. Baldessarini, Simon Forstmeier
Journal: Psychotherapy and Psychosomatics (2007)
Transverse myelitis associated with cat-scratch disease in an adult
Authors: R. G. Pickerill
Journal: JAMA (1981)

CAT-SCRATCH disease, also known as nonbacterial regional lymphadenitis, is an uncommon illness that afflicts children primarily and was first reported in the literature by Debre et al<sup>1</sup>in 1950. The disease is usually mild and self-limited and is characterized by subacute regional lymphadenitis, fever, and malaise. The causative agent is unknown, and no consistently effective medical treatment has yet been described. Neurological manifestations are rare and have been recognized since 1952, when the first case report of encephalitis associated with cat-scratch disease was published by Stevens.<sup>2</sup>An additional 24 cases with neurological complications have been described in the English-language literature since then.<sup>3-7</sup>The majority of these are reports of encephalopathy and convulsions. To our knowledge, there are only two cases of myelitis and radiculitis.<sup>8,9</sup>Both patients were younger than 18 years. We describe a case of cat-scratch disease in a 44-year-old adult complicated by myelitis presenting
State-Specific Prevalence of Cigarette Smoking Among Adults, and Children's and Adolescents' Exposure to Environmental Tobacco Smoke—United States, 1996
Journal: JAMA (1997)

In 1996, the prevalence of cigarette smoking was added to the list of nationally notifiable health conditions reported by states to CDC. The addition of a health-related behavior to the list of diseases and illnesses reflected the recognized role of tobacco use as the leading preventable cause of death in the United States. This report summarizes the 1996 prevalence of current smoking among adults in 49 states and the District of Columbia and presents state-specific estimates of environmental tobacco smoke (ETS) exposure for children and adolescents residing in homes where adults smoke. The findings indicate that state-specific smoking prevalence among adults varied twofold and that approximately 15 million children and adolescents were exposed to ETS in their home.
Encephalopathy after Portacaval Shunt
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcium infusion for reversal of adverse effects of intravenous verapamil
Authors: D. L. Morris
Journal: JAMA (1983)

VERAPAMIL hydrochloride has been shown to be useful in the treatment of symptomatic hypertrophic cardiomyopathy by decreasing left ventricular outflow obstruction, reducing left ventricular muscle mass, and increasing left ventricular diastolic compliance.<sup>1-4</sup>Verapamil-related hemodynamic and electrophysiological complications in these cases have been documented in those with high pulmonary capillary wedge pressures in the presence of left ventricular outflow obstruction, evidence of congestive heart failure, substantive atrioventricular nodal dysfunction, and hypotension.<sup>3</sup>Although clinical experience suggests that calcium may be effective in reversing the adverse effects of verapamil, such therapy has not been widely publicized.<sup>4-8</sup>We report a case of a patient with hypotension and profound bradycardia caused by verapamil therapy for hypertrophic cardiomyopathy, which responded well to calcium chloride. <h3>Report of a Case</h3> A 56-year-old woman with echocardiographic diagnosis of hypertrophic cardiomyopathy, asymmetric septal hypertrophy, and systolic anterior motion of the mitral valve was admitted to San Francisco
THE LATE MR. A. E. MORISON
Journal: BMJ (1924)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following THE LATE MR. A. E. MORISON Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
RBC zinc protoporphyrin to screen blood donors for iron deficiency anemia
Authors: R. B. Schifman
Journal: JAMA (1982)

We evaluated a rapid RBC zinc protoporphyrin (ZP) test in 1,147 male and 615 female blood donors to study its value in screening for evolving iron deficiency anemia. Fifteen men (1.8%) and 32 women (7.9%) who returned to donate were found to be anemic. A matched sample analysis between anemic and nonanemic donors demonstrated significant differences in serum ferritin levels, percent iron saturation, and the RBC ZP level from samples collected during the initial evaluation. Red cell ZP correlated well with the natural logarithm of serum ferritin in both men and women who later became anemic. The predictive value of RBC ZP levels compared favorably with that of the serum ferritin level. We also observed a strong association between the yearly donation frequency and RBC ZP concentration. These findings indicate that predonation RBC ZP testing may be useful in screening for iron depletion and potential risk of anemia in blood donors. (<i>JAMA</i>1982;248:2012-2015)
Adrenocortical Carcinoma: Clinical, Morphologic, and Molecular Characterization
Authors: A. Stojadinovic
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To define multimolecular phenotypes of adrenocortical carcinoma (ACC) and to correlate outcome with morphologic and molecular parameters. PATIENTS AND METHODS: Clinical data were analyzed for 124 patients, histopathologic slides for 67 primary tumors, and tissue specimens for 74 patients (38 primary and 36 metastatic tumors) with ACC and for 38 normal adrenal tissue samples. Molecular expression profiles were investigated by immunohistochemistry. The prognostic significance of 12 gross and histologic parameters in 67 primary ACCs was evaluated. Morphologic and protein expression patterns were correlated with disease-specific survival (DSS). Univariate influence of prognostic factors on DSS was analyzed by log-rank test and multivariate analysis by Cox regression. RESULTS: The median follow-up period was 4.7 years. Significant predictors of DSS included distant metastasis at time of initial presentation; venous, capsular, and adjacent organ invasion; tumor necrosis, mitotic rate, atypical mitosis, and mdm-2 overexpression. Five-year DSS by number (one to six) of adverse histologic parameters was as follows: one to two, 84%; three to four, 37%; more than four, 9% (P = .005).The phenotype Ki-67(−)p53(−)mdm-2(+)cyclinD1(−)Bcl-2(−)p21(−)p27(+) was observed in 83% of normal and 3% of malignant adrenal tissue (P = .01). Molecular phenotypic expression was more heterogeneous in malignant than in normal (10 v five phenotypes) adrenal tissue. CONCLUSION: Meticulous morphologic evaluation, mitotic count, and tumor stage are essential in determining prognosis for patients with ACC. Multimolecular phenotyping demonstrates that the molecular complexity and heterogeneity of these neoplasms are such that targeted therapy needs to be patient specific.
Making the liver young again
Authors: S Mackey
Journal: Hepatology (2003)

Hepatocyte transplantation is an alternative to whole liver transplantation. Yet, efficient liver repopulation by transplanted hepatocytes is low in livers of old animals. This restraint might be because of the poor proliferative capacity of aged donor hepatocytes or the regenerative impairment of the recipient livers. The age-dependent liver repopulation by transplanted wild-type hepatocytes was investigated in juvenile and senescent rats deficient in dipeptidyl-peptidase IV. Repopulation was quantified by flow cytometry and histochemical estimation of dipeptidyl-peptidase IV enzyme activity of donor cells in the negative host liver. As a potential pathway involved, expression of cell cycle proteins was assessed. Irrespective of the age of the donor hepatocytes, large cell clusters appeared in juvenile, but only small clusters in senescent host livers. Because juvenile and senescent donor hepatocytes were likewise functional, host-derived factor(s) impaired senescent host liver repopulation. Growth hormone levels were significantly higher in juvenile than in senescent rats, suggesting that growth hormone might promote host liver repopulation. Indeed, short-term treatment with growth hormone augmented senescent host liver repopulation involving the growth hormone–mediated release of the transcriptional blockade of genes associated with cell cycle progression. Short-term growth hormone substitution might improve liver repopulation by transplanted hepatocytes, thus augmenting the therapeutic benefit of clinical hepatocyte transplantation in older patients.
A Nurse's Hand-Book of Medicine.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal