tbuckley/cabot-search huggingface dataset:
POSTGRADUATE WORK IN LARYNGOLOGY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association News.
Authors: George H. Simmons
Journal: JAMA (1903)

<h3>EXCURSION RATES—NEW ORLEANS MEETING.</h3> Rules Governing Extension of Tickets. SOUTHERN PASSENGER ASSOCIATION. Atlanta, Ga., Jan. 22, 1903. <h3>To the Editor:</h3> —Referring to previous correspondence in regard to reduced rate and arrangements for the above meeting in New Orleans in May, attached please find copy of Passenger Tariff Exc.-1670, which shows detailed information as to special agency extension arrangements, etc. It may help your attendance to give this feature a wide circulation, as I have no doubt many of the delegates to your meeting will wish to make side-trip excursions. Very respectfully, Joseph Richardson, Chairman. <h3>Passenger Tariff No. Exc.-1670.</h3> Supplementing Passenger Tariff No. Exc.-1646. (SeeThe Journal, Jan: 8 p. 46.) The rules and regulations herein published are the separate rules and regulations of each of the following individual carriers and its connections: Illinois Central Railroad. Louisville &amp; Nashville Railroad. New Orleans &amp; Northeastern Railroad. Yazoo &amp; Mississippi Valley Railroad.
Oidiomycosis (BLASTOMYCOSIS ) of THE SKIN AND ITS FUNGI.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Career Opportunities
Journal: Environmental Health Perspectives (2002)

Supervise and manage high-throughput academic research on the role of environmental xenobiotics on the induction of mitogenactivated protein kinases and other signal transduction effectors and their effects on regulation of phase I and phase II drug metabolism genes and of other genes regulated by the aryl hydrocarbon receptor.Also actively participate and supervise experiments designed to study the effects of combined exposures to heavy metals or metalloids and polycyclic aromatic hydrocarbons on the regulations of these genes.Conduct research on analysis of genetic polymorphism in the human aryl hydrocarbon receptor and the physiologic consequences of the polymorphism.Requirements: Ph.D. in Environmental Health, Molecular Biology or related discipline.Must have experience in all the research fields mentioned above and in addition must be familiar with radioreceptor assays.
Biosimilar trastuzumab active post marketing surveillance real world 2020 data update: Results from a patient support program for patients under treatment with the first biosimilar trastuzumab approved in Brazil.
Authors: Allisson Monteiro da Silva, Thais Tiemi Wepeck Oliveira Watanabe, Eimy Honda, Juliana Yamaguchi
Journal: Journal of Clinical Oncology (2021)

e14504 Background: In 2017, biosimilar trastuzumab (Zedora) became the first biosimilar trastuzumab approved in Brazil. In May 2018 an active postmarketing surveillance program was instituted. Data from this program was presented in ASCO in 2019 and 2020. Now, with an extended follow up (May 2018 to December 2020) and more patients included, we present updated data from the surveillance program. Methods: This is a prospective observational study to evaluate data from the patient support program. Patients who received prescription for biosimilar trastuzumab were invited to participate. After agreement of informed consent, they were followed by periodical phone calls after each infusion and up to 3 months after the end of treatment. Treatment related data and adverse events (AEs) were collected. Results: A total of 74 reports containing 656 adverse events (AEs) were received from the active postmarketing surveillance program between May 2018 and December 2020. Of the 74 reports, 73 are female patients with HER2+ breast cancer (BC) and 1 is a male patient with gastric adenocarcinoma. The patients mean age was 52 years (31 to 79 years). Regarding to AEs severity and expectedness, 588 (89.63%) were non-serious AE (413 expected / 175 unexpected) and 68 (10.37%) were serious AE (51 expected / 17 unexpected). Considering all serious unexpected AEs (17), 13 were assessed as not related to trastuzumab therapy and 4 were assessed as related to therapy. For the 175 non-serious unexpected AEs, 56 were assessed as not related to therapy and 119 were assessed as related to therapy. The three most frequently reported AEs according to SOC (System Organ Classification) were general disorders and administration site conditions 111 (16.92%), gastrointestinal disorders 98 (14.93%) and nervous system disorders 88 (13.41%). The five most commonly reported adverse events (MedDRA PT - Preferred term) were diarrhea 27 (4.11%), fatigue 24 (3.66%), nausea 22 (3.35%), weight decreased 18 (2.74%) and infusion related reaction 17 (2.59%). Further monitoring is continued. Conclusions: Nature of AEs noted in patients with breast cancer and gastric cancer treated with biosimilar trastuzumab (Zedora) were consistent with the known safety profile of Trastuzumab. The risk benefit remains consistent with the reference safety information and no new safety signals were detected.[Table: see text]
Etudes sur les affections de la colonne vertébrale.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts
Journal: Annals of the Rheumatic Diseases (1958)

It is established that recurrences of rheumatic fever can be prevented in a high proportion of cases by anti- streptococcal prophylaxis.A preliminary investigation was carried out at Irvington House, Irvington-on- Hudson, New York, with the twofold object of deter- mining the comparative efficacy of three different prophy- lactic regimens and observing the natural history of rheumatic heart disease in the presence of continuous prophylaxis over a period of 5 years.The three regimens were:(1) sulphadiazine, 1 g. a day by mouth in a single dose;(2) penicillin, 200,000 units a day by mouth in a single dose half-an-hour before breakfast;(3) benzathine benzylpenicillin, 1,200,000 units in 2 ml.by intramuscular injection every 4 weeks.A total of 405 children, all of whom had had a definite attack of rheumatic fever within the preceding 28 months, were divided into eight groups: those without heart disease were divided into age groups 5 to 9 and 10 to 15 years and each age group was then subdivided into those who had been free from rheumatic activity for 3 to 4 months and those who had been free for 15 months or more; patients with heart disease were assigned to four similar groups.By a random allocation of patients to a prophylactic agent it was ensured that there were three treatment groups of approximately equal size in each of the eight groups.Each patient was seen once a month, throat swabs for culture being taken at each visit and blood for serological examination being obtained every other visit.253The results obtained in the first two years of the study, 1954 to 1956, showed that 1,200,000 units of benzathine penicillin administered intramuscularly every 4 weeks was more effective in preventing both streptococcal infections and recurrences of rheumatic fever than either of the other two prophylactics.The authors suggest that one reason for this superiority is that injection ensures that the drug is received, whereas there is no certainty that the patients take the drugs by mouth.Kenneth Stone.
Casopis Lekaru Ceskych, Praha
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NONOBSTRUCTIVE EMPHYSEMA
Authors: W. B. KOUNTZ
Journal: JAMA (1933)

It has been generally believed that the underlying lesion of emphysema is primarily in the lungs. Freund's<sup>1</sup>contention that the disease is not essentially a pulmonary disorder but is produced by ossification of the costal cartilages and ankylosis of the costovertebral junctions has been much discussed but has received little support from more recent anatomic investigations. Two clinical types of emphysema have long been recognized: One is associated with bronchial obstruction; the other, the nonobstructive type, which has received relatively little attention, has been called "senile" or "arteriosclerotic" emphysema and has been attributed to degenerative changes in the pulmonary tissue. This investigation is concerned with the second type of the disease. <h3>EXPERIMENTAL</h3> At the outset the respiratory function of patients with nonobstructive or senile emphysema was compared with that of normal controls and with that of patients with bronchial obstruction. In nonobstructive emphysema, it was noted that abdominal breathing
Gefitinib Approved for <i>EGFR</i>-Mutated NSCLC
Journal: Cancer Discovery (2015)

Abstract Ten years after the FDA restricted marketing of AstraZeneca's gefitinib (Iressa), the agency has approved the drug as first-line treatment for metastatic non–small cell lung cancer with exon 19 deletions or exon 21 L858R substitutions, along with a companion diagnostic kit.
Continuing Education Courses for Physicians
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Software
Authors: Bill McCarberg
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1130: Role Of PI3Kγ For Integrin-dependent Adhesive And Migratory Functions Of Progenitor Cells In Vitro And In Vivo
Authors: Emmanouil Chavakis, Guillaume Carmona, Triantafyllos Chavakis, Andreas M Zeiher, Stefanie Dimmeler
Journal: Circulation (2007)

Endothelial progenitor cells (EPC) are recruited to ischemic regions to improve neovascularization. β1- and β2-integrins play a crucial role for progenitor cell homing to ischemic tissues. Chemokines and their respective G-protein coupled receptors (GPCRs) are involved in the EPC homing to ischemic tissues. The phosphatidylinositol-3-kinase catalytic subunit gamma (PI3Kγ) is the PI3K isoform, which selectively transduces signals from GPCRs. Here, we investigated the role of PI3Kγ for integrin-dependent homing functions of progenitor cells. As assessed by western blot, EPC express the catalytic subunit PI3Kγ. We then studied the role of PI3Kγ for EPC migration. AS-605240 (100 nM), a selective PI3Kγ-inhibitor (Camps M, Nat. Med., 2005), significantly reduced the SDF1- and the IL-8-induced migration and the SDF1-induced transendothelial migration of human EPC. Adhesion is a further essential step during EPC homing to ischemic tissues. In this regard, the PI3Kγ-inhibitor significantly reduced the SDF1-induced adhesion of EPC on HUVEC monolayers by 69 ± 8 % and on ICAM-1, a β2-integrin ligand. However, the PI3Kγ-inhibitor did not affect the SDF1-induced adhesion of EPC on fibronectin, a β1-integrin ligand, suggesting that PI3Kγ in EPC is involved in the regulation of β2-, but not of β 1-integrin-dependent adhesion. In line with these results, inhibition PI3Kγ blocked the SDF1-induced increase of β2-, but not of β1-integrin-affinity in EPC. Beside EPC, the SDF1-induced migration and adhesion on ICAM-1 of murine bone marrow (BM)-derived Lin − progenitor cells from PI3Kγ-deficient mice (PI3Kγ − / − ) were reduced in comparison to wild type (WT) cells. In addition, PI3Kγ-deficiency led to a significant reduction of homing of murine BM-Lin − progenitor cells to ischemic muscles after intravenous infusion in the model of hind limb ischemia in comparison to WT cells (48 ± 8 % inhibition). In conclusion, these data demonstrate that PI3Kγ plays an essential role for the integrin-dependent homing of progenitor cells in vitro and in vivo. The understanding of the molecular mechanisms of progenitor cell homing is essential for the development of new therapeutic strategies in order to improve the efficacy of cell-based therapies in patients with ischemic disorders.
Syphilitic interstitial keratitis
Authors: M. E. Lee
Journal: JAMA (1989)

A 49-year-old otherwise healthy Chinese immigrant presented with a chief complaint of decreased vision in both eyes of several years' duration. The patient reported that at age 20 years she "went blind" in both eyes and was unable to see for several months. Following the use of Chinese herbal medicine topically and penicillin shots intramuscularly, she partially regained her vision. Examination revealed highly arborized interstitial corneal vessels associated with deep stromal scarring that caused corneal opacity (Figs 1 and 2). Numerous red blood cells were seen by retroillumination. Laboratory results were negative for the rapid plasma reagin test and positive for microhemagglutination assay<i>Treponema pallidum</i>(MHA-TP, a specific antibody test), which were compatible with treated syphilis. Interstitial keratitis is an increasingly uncommon condition that is a manifestation of prenatal syphilis.<sup>1</sup>It is thought to be the result of an immunologic phenomenon directed against treponemal antigens deposited in the cornea.
Erratum
Authors: None &NA;
Journal: Clinical Nuclear Medicine (1978)

The sacral tubercle, S1 posterior spinous process, can appear as intense as the sacroiliac joints on posterior bone scan in 4% of normal adult male patients. Due to sexual differences in anatomy, the scan appearance of the sacrum can cause false-positive readings. The converse, false-negative readings, can occur if the sacral intensity is taken as a constant when comparing ratios of sacroiliac joint intensities and sacral intensities on bone scans of patients with sacroiliac disease. This study demonstrates the normal anatomy of the sacrum and presents a sequence of tests to diagnose disease in the sacrum.
Maternal Depression and Children’s Antisocial Behavior: Nature and Nurture Effects
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MRI
Authors: Judith Skillman
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
January 3, 2001
Journal: JAMA (2001)

Tarja Anttila, MD; Pekka Saikku, MD; Pentti Koskela, PhD; Aini Bloigu, BSc; Joakim Dillner, MD; Irma Ikäheimo, PhD; Egil Jellum, PhD; Matti Lehtinen, MD; Per Lenner, MD; Timo Hakulinen, PhD; Ale Närvänen, PhD; Eero Pukkala, PhD; Steinar Thoresen, MD; Linda Youngman, PhD; Jorma Paavonen, MD