tbuckley/cabot-search huggingface dataset:
Captopril in renovascular hypertension: long-term use in predicting surgical outcome.
Authors: A B Atkinson, J J Brown, A M Cumming, R Fraser, A F Lever, B J Leckie, J J Morton, J I Robertson
Journal: BMJ (1982)

The angiotensin converting-enzyme inhibitor captopril was used as long-term preoperative treatment in a series of hypertensive patients with unilateral renal arterial disease. There were immediate and sustained falls in plasma angiotensin II and aldosterone concentrations, with converse increases in circulating renin and angiotensin I. In patients with sodium and potassium deficiency and secondary aldosterone excess before treatment captopril corrected the sodium and potassium deficits; in these cases the initial hypotensive response was profound but the later effect was less pronounced. When sodium and potassium state was initially normal it remained unchanged during captopril treatment, while the full hypotensive effect took up to three weeks to be attained. The immediate, but not long-term, falls in arterial pressure with captopril were proportional to the immediate decrements of plasma angiotensin II. Nevertheless, while the immediate blood-pressure reduction with captopril variously overestimated and underestimated the eventual surgical response, the absolute blood-pressure values during long-term captopril related well with those after operation. Pretreatment plasma renin and angiotensin II concentrations, while closely predicting the immediate captopril response, are fallible guides to surgical prognosis. In contrast, long-term treatment with converting-enzyme inhibitors may provide an accurate indication of surgical outcome.
Practical Treatise on Diseases of the Digestive System.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic Ultrasonography
Authors: P. R. Pfau, A. Chak
Journal: Endoscopy (2002)

Over the past two decades, endoscopic ultrasonography (EUS) has undergone a transition from being a novel imaging technique to a clinical diagnostic test that is necessary for the optimal management of gastrointestinal diseases. EUS has established itself as an important diagnostic modality, mainly for the detection and staging of gastrointestinal cancers. As EUS has become more widespread, research has gradually shifted towards studies that explore the effect of EUS on patient management and outcome. These outcome studies have examined the primary clinical applications of EUS, such as esophageal, gastric, pancreatic, and colorectal cancer staging, as well as the role of EUS in the diagnosis of inflammatory pancreatic diseases. Widespread use of EUS has recently led to studies that examine complications associated with the performance of the procedure. Endosonographers have continued efforts to define a clinical role for EUS in other gastrointestinal diseases, such as portal hypertension. EUS-guided fine-needle aspiration (FNA) is continuing to develop into a powerful diagnostic tool for the management of lung cancer and other mediastinal diseases. New applications for EUS-FNA are also emerging. Finally, investigators are continuing to explore the remaining frontier of EUS-guided therapy.
Zur Kenntnis der psychischen Residuärzustände nach Encephalitis epidemica bei Kindern und Jugendlichen, insbesondere der weiteren Entwicklung dieser Fälle.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety and efficacy of tenofovir alafenamide in geriatric patients with chronic hepatitis B: experience from four ongoing phase 2 and phase 3 clinical trials
Authors: Scott Fung, Maurizia Brunetto, Maria Buti, Pietro Lampertico, Kosh Agarwal, Wan-Long Chuang, Namiki Izumi, Mandana Khalili, Alnoor Ramji, Ho Bae, Xiaoli Ma, Shuyuan Mo, John F. Flaherty, Anuj Gaggar, Vithika Suri, Susanna Tan, Mani Subramanian, Calvin Pan, Patrick Marcellin, Harry Janssen, Edward Gane, Henry Chan
Journal: Journal of Hepatology (2020)
Hypertensive Heartbreak
Authors: Emily S. Lau, Anand Vaidya, Inga-Marie Schaefer, Benjamin M. Scirica
Journal: New England Journal of Medicine (2021)

A 61-year-old man was transferred to the cardiac care unit after having cardiac arrest the day after left total knee arthroplasty. Cardiopulmonary resuscitation was initiated, and chest compressions, epinephrine, sodium bicarbonate, and calcium chloride were provided for 15 minutes, after which his pulse, blood pressure, and electrical rhythm were detectable. . . .
Table of contents
Authors: Giuseppe Caso, Barbara Garlick, George Casella, Dawn Sasvary, Peter Garlick, Yin Liang, Melville Osborne, Brett Monia, Sanjay Bhanot, Lynnetta Watts, Pengxiang She, Stephanie Decarlo, Xiaoli Chen, Keith Demarest, Guillaume Ruel, Sonia Pomerleau, Patrick Couture, Benoît Lamarche, Charles Couillard, Heinz Zotter, Reinhold Kerbl, Siegfried Gallistl, Reingard Aigner, Gerhard Pichler, Martin Borkenstein, Ifigenia Giannopoulou, Bo Fernhall, Robert Carhart, Ruth Weinstock, Tracy Baynard, Arturo Figueroa, Jill Kanaley
Journal: Metabolism (2005)
Explaining the rise in antidepressant prescribing: a descriptive study using the general practice research database
Journal: BMJ (2009)

Objective To explore the reasons behind the recent increase in antidepressant prescribing in the United Kingdom.Design Detailed retrospective analysis of data on general practitioner consultations and antidepressant prescribing.Data source Data were obtained from the general practice research database, which contains linked anonymised records of over 3 million patients registered in the UK.Data were extracted for all new incident cases of depression between 1993 and 2005.Review methods Detailed analysis of general practitioner consultations and antidepressant prescribing was restricted to 170 practices that were contributing data for the full duration of the study.Results In total, 189 851 people within the general practice research database experienced their first episode of depression between 1993 and 2005, of whom 150 825 (79.4%) received a prescription for antidepressants in the first year of diagnosis.This proportion remained stable across all the years examined.The incidence of new cases of depression rose in young women but fell slightly in other groups such that overall incidence increased then declined slightly (men: 7.83 cases per 1000 patient years in 1993 to 5.97 in 2005, women: 15.83 cases per 1000 patient years in 1993 to 10.06 in 2005).Antidepressant prescribing nearly doubled during the study period-the average number of prescriptions issued per patient increased from 2.8 in 1993 to 5.6 in 2004.The majority of antidepressant prescriptions were given as long term treatment or as intermittent treatment to patients with multiple episodes of depression.Conclusions The rise in antidepressant prescribing is mainly explained by small changes in the proportion of patients receiving long term treatment.Previous clinical guidelines have focused on antidepressant initiation and appropriate targeting of antidepressants.To address the costly rise in antidepressant prescribing, future research and guidance needs to concentrate on appropriate long term prescribing for depression and regular review of medication.
Der Mensch: Vom Werden, Wesen und Wirken des menschlichen Organismus.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physical Therapy for Gonorrheal Arthritis.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myelodysplastic Syndrome
Authors: Wolf-K. Hofmann, H. Phillip Koeffler
Journal: Annual Review of Medicine (2005)

During the past 15 years, important progress has been made in the understanding of the biology and prognosis of myelodysplastic syndrome (MDS). MDS is a clonal disorder characterized by ineffective hematopoiesis, which can lead to either fatal cytopenias or acute myelogenous leukemia (AML). Risk-adapted treatment strategies were established because of the high median age (60–75 years) of the MDS patients and the individual history of the disease (number of cytopenias, cytogenetic changes, transfusion requirements). Allogeneic bone marrow transplantation currently offers the only potentially curative treatment, but this form of therapy is not available for the typical MDS patient, who is &gt;60 years of age. Therapy with erythropoietin and G-CSF has improved the quality of life of selected patients. The development of small molecules directed against specific molecular targets with minimal adverse effects is the hope for the future. Innovative uses of immunomodulatory agents and the optimizing of cytotoxic treatment should continue to help in the treatment of MDS.
Leon Kaufman
Authors: R Ginsburg
Journal: BMJ (2018)

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The Baker Memorial: A Study of the First Ten Years of a Unit for People of Moderate Means at the Massachusetts General Hospital
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholesterol lowering with statin drugs: evidence in women
Authors: M. B. Wagner
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The article by Dr Hebert and colleagues,<sup>1</sup>which reviewed acute cardiovascular events and deaths in trials of statin drugs, does not comment on the outcome of the female patients included in these trials. Of the 13 secondary prevention trials, 1 included no female patients, and only 3 (Expanded Clinical Evaluation of Lovastatin [EXCE L], Scandinavian Simvastatin Survival Study [4S], and Cholesterol and Recurrent Events [CARE]) enrolled more than 100 female patients and followed up patients for more than 1 year. The EXCEL trial<sup>2,3</sup>enrolled approximately 3389 female patients and the follow-up period was 48 weeks. However, patients were divided into 5 treatment groups, with no significant differences in adverse outcomes between the groups. No power calculation was performed and the authors did not report data on female patients separately. A total of 827 female patients were enrolled in the 4S study,<sup>4</sup>with a
DSP 突变与致心律失常性心肌病
Authors: T. Maruthappu, A. Posafalvi, S. Castelletti, P.J. Delaney, P. Syrris, E.A. O'Toole, K.J. Green, P.M. Elliott, P.D. Lambiase, A. Tinker, W.J. McKenna, D.P. Kelsell
Journal: British Journal of Dermatology (2019)

致心律失常性心肌病 (AC) 是一种相对罕见的心肌遗传性疾病,可能导致患者(通常低于 35 岁)猝死。AC 对于医生可能难以诊断,因为初始症状通常轻微,以至于可能被忽视。在一种罕见形式的 AC 中,受累患者还可能有明显的卷发和掌跖部皮肤异常增厚。这可能使诊断变得较为容易。这项来自英国伦敦的研究调查了存在一种由于桥斑蛋白突变导致的更为常见形式 AC 的家族,桥斑蛋白在心脏和皮肤中作为细胞之间的“胶水”发挥作用。我们证实,大多数 AC 家族成员有卷发,相当比例的患者还有导致皮肤增厚的问题。来自 AC 患者的皮肤活检显示,多种负责细胞间彼此连接的蛋白存在异常,这些蛋白对于心肌中的脉冲传导和收缩信号传导也至关重要。早期诊断和家族筛查是 AC 管理的关键目标。这项研究还在 AC 中发现了桥斑蛋白突变导致的两个新特征,第一个是在大部分受影响家族成员中存在卷发和皮肤问题。第二个是在来自 AC 患者的皮肤活检标本中发现若干蛋白异常。因此皮肤和毛发检查可能提供一个快速诊断 AC 的特殊机会窗口。
CORRECTION
Journal: Annals of the Rheumatic Diseases (2007)

graded 0-3 by the previous method) 9 and synovial proliferation of thickness >2 mm (graded 0-3 by Rubaltelli's method) 10 on power Doppler, as well as RI and PI values.As shown in table 1, compared with joints with deep pattern signals, joints with superficial pattern signals had significantly higher flow signal (p,0.001) and synovial effusion (p,0.001)grades, and significantly lower RI values (p,0.001).On the other hand, joints with deep pattern signals had a significantly higher grade of synovial proliferation (p = 0.010).
Text-book of Otology for Physicians and Students.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Recurrent SET-NUP214 Fusion as a New HOXA Activation Mechanism in Pediatric T-Cell Acute Lymphoblastic Leukemia.
Authors: Pieter Van Vlierberghe, Joelle Tchinda, Martine van Grotel, Charles Lee, H. Berna Beverloo, Peter van der Spek, Andrew Stubbs, Jan Cools, Kyosuke Nagata, Maarten Fornerod, Jessica Buijs-Gladdines, Martine Horstmann, Elisabeth R. van Wering, Jean Soulier, Rob Pieters, Jules P.P. Meijerink
Journal: Blood (2007)
Abstract 1158: Mitral Leaflet Remodeling: Response to Isolated Mitral Regurgitation
Authors: Elizabeth H Stephens, Tom C Nguyen, Akinobu Itoh, David C Miller, K. Jane Grande-Allen
Journal: Circulation (2007)

Objectives: Chronic mitral regurgitation (MR) adversely remodels the left ventricle. Although leaflet integrity is important for mitral coaptation, its response to isolated MR remains unknown. In a chronic ovine model, we hypothesize that isolated MR also adversely remodels the mitral leaflet. Methods: 29 sheep were randomized to either control (CTRL, n=11) or experimental groups (HOLE, n=18). In HOLE, a 2.8 – 4.8mm diameter hole was punched in the middle scallop of the posterior mitral leaflet. MR grade was followed by echocardiography. At 12 weeks, immunohistochemistry (IHC) was performed on anterior and posterior mitral leaflet cross-sections to demonstrate active matrix remodeling, including markers for active collagen synthesis synthesis and cross-linking prolyl 4-hydroxylase (P4H), heat shock protein 47 (HSP47), and lysyl oxidase (LOX) and matrix metalloproteinases (MMPs 1, 2, 9, 13) largely responsible for matrix degradation implicated in valvular pathologies. The proteoglycans biglycan (BGN), decorin (DC), and versican (VC), the glycosaminoglycan hyaluronan (HA), as well as fibrillin (F), and collagen III (col 3), all of which regulate matrix organization, were also visualized using IHC. A semi-quantitative intensity and delineation grading scale (from 0 to 3) was used to quantify differences between the HOLE and CTRL leaflets. Results: At 12 weeks, MR grade was greater in HOLE v CTRL (0.4±0.4 v 3.0±0.8, p &lt; 0.001). In HOLE, valve matrix remodeling reduced hole diameter (69.5%32±.8%, p&lt;0.001). The overall intensity of P4H, MMP13, and HSP47 decreased (1.02 v 1.30, p&lt;0.02) while BGN, DC, and HA staining delineation increased 34 fold around the hole compared to CTRL (1.22 v 0.36, p&lt;0.01). In the anterior leaflet of HOLE, P4H, LOX, MMPs, F, col 3, and HA were increased (1.43 v 1.24), while VC, DC, and BGN were decreased (1.66 v 1.84) compared to CTRL (both p≤0.05). Conclusions: In HOLE, significant remodeling was evident in the posterior leaflet near the site of injury; moreover expression of matrix turnover markers increased in the anterior leaflet due to the chronic low pressure LV volume overload. This adverse remodeling in the anterior leaflet in response to MR may explain how “MR begets MR,” providing insight for reparative surgical techniques.
Acute ischemic retinopathy due to gentamicin injection
Authors: H. Schatz
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We recently reviewed a number of cases in which gentamicin was inadvertently injected into an eye and caused blindness. The clinical picture of acute ischemic gentamicin toxicity of the retina and optic nerve is a remarkable one (Figure). The entire retina becomes ischemic and necrotic.<sup>1-3</sup> In the cases seen, gentamicin was either mistaken for balanced salt solution, or some other medication, and injected into the eye or was injected in such a way that a high concentration of it came in contact with the retina. Near the end of intraocular surgery, eye surgeons may inject balanced salt solution or some other physiological solution into the eye in order to regain intraocular pressure. In addition, at the end of certain eye operations, gentamicin is often injected under the conjunctiva, prophylactically.<sup>4</sup>If the gentamicin is drawn up early in the case and left in an unlabeled syringe,
Primary celiac plexus syndrome. A reasonable explanation for abdominal pain?
Authors: E. D. Palmer
Journal: JAMA (1975)

THE EUROPEAN medical literature of the World War I era showed an active interest in the concept that the celiac (solar) plexus can be a source of abdominal pain in the absence of any visceral disease or emotional disturbance. Well-known authors wrote about "celiac ganglion pain" and the "solar plexus syndrome"—Bichat, Glénard, Roux, and others. Enthusiasm was not sustained, however, perhaps because it was not possible to put the concept of an anatomically localized explanation for functional pain to an objective test. In more recent times, the matter was discussed further, again by thoughtful clinicians—Walton, Maratza, Moolten, and others. It has not caught on. Perhaps it should be given another hearing. When carcinoma of the pancreas engulfs the celiac plexus, a classical pain syndrome is produced. Its features are so precise and predictable that, when full-blown, it is recognized with some assurance at the bedside. In primary celiac plexus syndrome,