tbuckley/cabot-search huggingface dataset:
HOUT-18. COST EFFECTIVENESS OF TREATING GLIOBLASTOMA PATIENTS AGE 65 YEARS OR OLDER WITH TUMOR TREATING FIELDS PLUS TEMOZOLOMIDE VERSUS TEMOZOLOMIDE ALONE
Authors: Gregory Guzauskas, Bruce CM Wang, Erqi Pollom, Volker W Stieber, Lou Garrison
Journal: Neuro-Oncology (2018)

TTFields plus TMZ treatment significantly increased five-year overall survival results compared to TMZ alone in all patients in the EF-14 trial, with the subgroup of patients age 65 and older showing the greatest survival benefit (hazard ratio 0.51 [CI 0.33–0.77]). This is the first report on the cost-effectiveness of TTFields in elderly GBM patients. Patient outcomes were simulated using a 3-state area under the curve model. Survival was modelled over a lifetime horizon by integrating 5-year survival results of the EF-14 trial with long-term GBM epidemiology data and U.S. background mortality rates. Patient utilities from a previous publication were used to calculate quality-adjusted life years (QALYs). Adverse events of TTFields and TMZ were derived from the EF-14 trial for patients over 65 years, the costs from published literature. Elderly patients treated with TTFields and TMZ achieved mean lifetime survival of 3.66 years (3.04 years discounted). Patients treated with TMZ alone achieved a mean lifetime survival of 1.32 years (1.29 years discounted) The resulting incremental life years gained were 1.75 years discounted and the incremental quality-adjusted life years (QALYs) were 1.35. The incremental total cost was $192,000. The ICER was $109,500 per LYG and $142,400 per QALY gained. The probability of TTFields being cost-effective was 85% at a willingness-to-pay threshold of $200,000 per QALY. Treating newly diagnosed GBM patients over 65 years with TTFields and TMZ has the potential to increase mean lifetime survival and quality-adjusted survival substantially compared to TMZ alone. TTFields therapy, even when evaluated at its full list price, demonstrated high probability of cost-effectiveness at willingness-to-pay thresholds reported in economic literature for the United States. These results indicate that patients over age 65 may not only benefit from TTFields treatment, but also that their treatment may be cost-effective.
Rapid Response Team Responses
Authors: David B. Seder
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lenti in red: progress in gene therapy for human hemoglobinopathies
Authors: Christof von Kalle, Christopher Baum, David A. Williams
Journal: Journal of Clinical Investigation (2004)

Hemoglobinopathies are caused by abnormal structure or synthesis of hemoglobin chains and represent serious monogenic disorders. A new study demonstrates that lentiviral vectors can express clinically relevant levels of human transgenic beta-globin in red cells of xenografted mice. While some safety concerns must be addressed, this study is an important step toward potential clinical trials of gene therapy for hemoglobinopathies.
The Jew in Science
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POLO: Radiologic assessment of the impact of maintenance olaparib in patients (pts) with metastatic pancreatic cancer (mPaC).
Authors: Lawrence Howard Schwartz, Hedy L. Kindler, Pascal Hammel, Michele Reni, Eric Van Cutsem, Teresa Macarulla, Michael J. Hall, Joon Oh Park, Daniel Hochhauser, Dirk Arnold, Do-Youn Oh, Anke Reinacher-Schick, Giampaolo Tortora, Hana Alguel, Eileen Mary O'Reilly, Jeremie Fromageau, Dana C. Ghiorghiu, David McGuinness, Gershon Y. Locker, Talia Golan
Journal: Journal of Clinical Oncology (2020)

e16800 Background: The Phase III POLO study (NCT02184195) demonstrated a benefit of maintenance olaparib over placebo in the radiologically assessed primary endpoint of progression-free survival (PFS) in pts with mPaC (median 7.4 vs 3.8 months [mo]; 12-mo rate 34% vs 15%). The impact of radiologic assessment of pancreatic lesions, which is considered challenging, was explored. Methods: Tumors were assessed using Response Evaluation Criteria in Solid Tumors version 1.1 by blinded independent central review (BICR) in pts with mPaC treated with maintenance olaparib or placebo. PFS was analyzed in subsets of pts based on various event criteria. Results: All 154 randomized pts had mPaC prior to chemotherapy, of whom 122 had disease in the pancreas at POLO baseline (BL); 34% (53/154) had pancreas-only target lesions (TL), 26% (40/154) also had ≥1 TL outside of the pancreas, and in 19% (29/154) pancreatic disease was recorded as non-TL. Sensitivity analyses were consistent with the primary PFS analysis (Table), including when all pancreas lesion assessments were discounted (median PFS 7.4 vs 4.7 mo; 12-mo rate 38% vs 22%). Of 53 pts with pancreas-only TLs at BL, 34 had disease progression (PD); in 20 pts this was not solely based on TL measurements (16 had new lesions; 4 had multiple-cause PD). Confirmed objective responses occurred during study maintenance treatment in 20% of olaparib pts (18/92) and 10% of placebo pts (6/62). In pts with pancreas-only TLs at BL there were 7 responses in the olaparib arm (1 complete response [CR], 6 partial responses [PR]) and 2 (2 PR) in the placebo arm. In pts who had ≥1 TL outside of the pancreas at BL there were 11 (1 CR, 10 PR) and 4 (4 PR) responses, respectively. Responses were generally durable irrespective of TL location. Conclusions: The significant PFS benefit with maintenance olaparib over placebo shown in the primary analysis was consistent across all sensitivity analyses and was not impacted by radiologic assessment of pancreatic TLs. Taken together, these findings suggest that contrary to historically held belief, primary pancreas TLs may be appropriate for inclusion as sites of RECIST-evaluable disease and for assessment of treatment outcome. Clinical trial information: NCT02184195 . [Table: see text]
Seronegative Lyme Disease
Authors: R I Henkin
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Editors' Choice
Authors: Donald Y.M. Leung, Stanley J. Szefler
Journal: Journal of Allergy and Clinical Immunology (2015)

Eosinophilic esophagitis is an inflammation of the esophagus. Symptoms of this chronic (lifelong) allergic inflammatory disease include difficulty in swallowing food and abdominal pain. Evaluating treatments currently involves looking at changes in the tissues and cells of the esophagus. However, to improve both clinical outcomes and patients' quality of life, there is a need to objectively measure and consider patients' symptoms and how they feel. Using a questionnaire called the Pediatric Eosinophilic Esophagitis Symptom Score (PEESS v2.0), Martin et al (p 1519) showed that categories of questions assessing related symptoms corresponded with clinical and biologic features of pediatric eosinophilic esophagitis.
False-positive tests for syphilis revisited. The intersection of Bayes' theorem and Wassermann's test
Authors: G. W. Waring
Journal: JAMA (1980)

ALMOST simultaneously two important journals have called editorial attention to the limitations of the stress ECG in the diagnosis of coronary artery disease.<sup>1,2</sup>It is said that there are excessive numbers of false-positive tests in patients at low risk of disease and false-negatives in those at high risk. Both discussions invoke a concept from probability theory known as Bayes' theorem, which one writer explicitly advises the clinician to master. <h3>False-positive Tests for Syphilis</h3> The issue is reminiscent of what was called "the false-positive problem" in syphilis about which much was written 30 years ago. This article briefly reviews that subject, a matter of historic interest, since the Wassermann test and its modifications were the first important tests acknowledged to possess an inherent tendency to false reactivity. It also furnishes an instructive example of the connection between the value of a test and the prevalence of the disease sought, which
PHYSIOLOGICAL DIFFICULTIES AT THE CLARK UNIVERSITY.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Respiratory monitoring
Authors: M. J. Tobin
Journal: JAMA (1990)

SIGNIFICANT improvements in respiratory monitoring have occurred over the last decade based on both technologic advances and a better understanding of the pathophysiologic characteristics of respiratory failure.<sup>1</sup>The major goals of monitoring are to provide alarms that alert the patient's attendants of a significant change in his/her condition, providing an opportunity for the timely institution of lifesaving measures, to aid with diagnosis and therapy, and to create trends that assist in assessing therapeutic response and predicting prognosis. Since many patients admitted to an intensive care unit never receive interventional therapy, the possibility arises that intensive care unit costs could be decreased by the employment of intermediate care units, where patients are admitted for monitoring until a need for interventional therapy has been demonstrated.<sup>2-6</sup>The features of an ideal monitoring system are listed in Table 1. In considering the various monitoring devices, it is useful to group the phenomena
3 Needles
Authors: Khalid Ali
Journal: BMJ (2005)

Directed by Thom Fitzgerald Shown at the London Film Festival on 31 October and 1 November Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> T he Canadian film 3 Needles is a challenging attempt to analyse the role of the West in causing disease and poverty in the developing world. Set in South Africa, China, and Canada, it weaves together three stories with the common theme of blood, religion, and sacrifice. It begins in South Africa, portraying the rituals of male circumcision and young adolescents' entry into a new world of manhood and adult responsibilities. Into … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Health of London
Journal: BMJ (1939)

STATISTICAL TABLES*The County of London, with its four million people, living in 800,000 houses, spread over an area of little more than one hundred square miles, continues to enjoy excellent health, immunity from epidemics, and a low death rate.The death rate in 1937 was 12.5 per thousand, a fraction lower than the death rate for Great Britain and Northern Ireland.It has, indeed, stood at a lower figure;
Medical Professionalism
Authors: Catherine D. DeAngelis
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Croup
Authors: Ioana Baiu, Elliot Melendez
Journal: JAMA (2019)

CroupCroup is a common upper respiratory tract infection that can affect young children.Croup typically occurs in the fall and winter months and is caused by parainfluenza or influenza viruses, adenovirus, or respiratory syncytial virus.These viruses cause inflammation of the larynx (voice box) and the trachea; hence, the clinical name of croup is laryngotracheitis.The inflammation leads to swelling and redness of these structures, which can affect a child's voice as well as ability to breathe.
Physician-assisted suicide
Authors: C. Campbell
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The article by Ms Alpers and Dr Lo<sup>1</sup>leaves readers with erroneous impressions regarding Oregon's Death With Dignity Act. We question whether their strategies for implementation will achieve their stated goal of improving care for terminally ill patients. The Death With Dignity Act did not legalize physician "assisted suicide" in Oregon, contrary to both the title and content of the essay. Assistance in suicide remains illegal under a 1983 Oregon statute.<sup>2</sup>The Death with Dignity Act explicitly states that the provision by a physician of patient-requested prescriptive medications to end life does not constitute assisted suicide. Moreover, it is misleading to characterize the act as authorizing physician assistance in dying, an approach that diminishes the significance of other caregivers in the process, including consultants, psychiatrists, nurses, pharmacists, and institutions. Alpers and Lo give physicians an unwarranted professional primacy, which we believe will lead not to
Highlights
Journal: JAMA (2019)

Patients receiving mechanical ventilation are typically assessed for their readiness to be weaned from ventilatory support after a trial of spontaneous breathing.Subirà and colleagues randomized 1153 patients who were receiving mechanical ventilation and found that a trial of spontaneous breathing consisting of 30 minutes of pressure support ventilation, compared with 2 hours of T-piece ventilation, led to higher rates of successful extubation.In an Editorial, Girard and Burns discuss the importance of recognizing the earliest time when patients are ready for extubation.
Dr. Ian Casimir Funk Is Not Dead
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CAN HUMAN CANCER BE TRANSPLANTED INTO LOWER ANIMALS?
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
S118 Direct visualisation of collateral ventilation in COPD with hyperpolarised Gas MRI
Authors: H. Marshall, M. H. Deppe, J. Parra-Robles, S. Hillis, C. Billings, S. R. Miller, J. H. Watson, J. Wolber, D. A. Lipson, R. Lawson, J. M. Wild
Journal: Thorax (2011)

<h3>Introduction and Objectives</h3> Collateral ventilation is important in pathophysiology of Chronic Obstructive Pulmonary Disease (COPD), complicated pneumothorax, and bronchoscopic lung volume reduction surgery but limited observations of it in vivo have been attained. Current techniques capable of imaging collateral ventilation require monitoring over multiple breathing cycles and use ionising radiation. Here we present the first single-breath demonstration of collateral ventilation, by using hyperpolarised gas MRI. <h3>Methods</h3> Ten patients with moderate to severe COPD as defined by NICE guidelines were scanned using a 1.5T whole body MRI system. A mix of 200 ml hyperpolarised <sup>3</sup>He and 800 ml N<sub>2</sub> was inhaled, and <sup>3</sup>He MR images were acquired. 3D images with full lung coverage were acquired at six time-points during a single breathhold. <h3>Results</h3> Abstract S118 figure 1 shows example sequential images in one patient, with insets highlighting an area with late ventilation. Hyperpolarised <sup>3</sup>He MR signal is non-renewable and diminishes over time. In normally ventilated regions of the lung this expected signal decay is observed. However, in the regions indicated with arrows the signal <i>increases</i> over time due to collateral ventilation, with a progressive influx of polarised gas from the edge of the defects towards the centre. The long time constants for ventilation of some areas are not compatible with their ventilation via their feeding bronchi. Instances of collateral ventilation were observed in eight of the ten patients scanned. These examples varied in defect size, number and fill-rate from the strongest case (Abstract S118 figure 1) to much more subtle effects. <h3>Conclusions</h3> A method for direct visualisation of collateral ventilation within a single breath-hold has been demonstrated in COPD patients for the first time. The technique gives 3D full lung coverage, and is non-invasive and non-ionising. The ability to image collateral ventilation directly may help to understand pathophysiology in COPD and aid assessment for therapy.
REFERRAL PATTERNS AND PERCEIVED BARRIERS TO ADULT CONGENITAL HEART DISEASE CARE: RESULTS OF A SURVEY OF U.S. PEDIATRIC CARDIOLOGISTS
Authors: Susan M. Fernandes, Laurie Fishman, Gregory S. Sawicki, Joanne O&apos;Sullivan-Oliveira, Paul Khairy, Sonja Ziniel, Kelly J. Conn, Petar Breitinger, Masato Takahashi, Roberta Williams, Michael Landzberg
Journal: Journal of the American College of Cardiology (2012)