tbuckley/cabot-search huggingface dataset:
Dyspnea and Cyanosis: Part 1 of Clinical Treatises on the Symptomatology and Diagnosis of Disorders of Respiration and Circulation.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Caring for the Uninsured and Underinsured
Authors: E. Scott Medley
Journal: JAMA (1991)

<h3>To the Editor.—</h3> With more than 40 000 people living below the poverty level in Alachua County, Florida, we are acutely aware of the problems facing the medical community in caring for the uninsured and underinsured. Though we do not propose to have a solution for the high cost of health care for the indigent, we are proud of our local safety-net program called the "We Care Physician Referral Network." The network, which was established informally in 1985, provides an innovative way for physicians to volunteer their time while providing access to specialty care for many of our area's indigent. In light of our new governor's budget proposal to assess all physicians $500 to help pay for health care for the indigent, I encourage others to organize their indigent care programs to show that physicians are already donating more than that in free health care. This is basically how our
Pelvic inflammatory disease. Key treatment issues and options
Authors: H. B. Peterson
Journal: JAMA (1991)

<h3>Objective.</h3> —To examine available data regarding optimal antimicrobial therapy for pelvic inflammatory disease (PID) and to address selected treatment issues confronting clinicians caring for women with PID. <h3>Data Sources.</h3> —Studies evaluated to help establish the Centers for Disease Control's 1989 Sexually Transmitted Diseases Treatment Guidelines and other reports published since 1985. A MEDLINE search of English-language literature was conducted using the indexing terms "pelvic inflammatory disease" or "pelvic infections" or "salpingitis" and "treatment." In addition, abstracts and bibliographies of articles and books were reviewed. <h3>Study Selection.</h3> —Studies were selected for detailed review if they evaluated the effectiveness of an antimicrobial regimen for treatment of PID. <h3>Data Extraction.</h3> —All studies were evaluated to determine the numbers of women treated and the percentage with clinical or microbiologic evidence of cure. <h3>Data Synthesis.</h3> —A variety of combination antimicrobial regimens are highly effective in providing clinical and microbiologic evidence of cure; few data are available to assess optimal therapy for prevention of late sequelae. Because PID is polymicrobial in cause, recommended antimicrobial regimens are broadspectrum in coverage. <h3>Conclusions.</h3> —No single agent that provides sufficient coverage is currently available. Several combination regimens appear highly effective clinically even among women with tubo-ovarian abscess formation. Uncertainties regarding the effectiveness of antimicrobial therapy for prevention of late sequelae complicate decisions regarding the choice among regimens and the appropriateness of ambulatory treatment of women with PID. Pending better data, hospitalization should be strongly considered, where feasible, particularly for those women with PID desiring further childbearing. Sex partners of all women with PID should be treated. (<i>JAMA</i>. 1991;266:2605-2611)
Coloscopie assistée par endocuff versus coloscopie assistée par capuchon pour la détection de l'adénome: résultats d'une étude randomisée
Journal: Endoscopy (2019)

La coloscopie est l’examen de référence pour la détection des polypes colorectaux. Néanmoins, une proportion non négligeable (jusqu’à 25 %) de polypes peut être manquée lors de l’examen. Il s’agit en général de petits polypes situés derrière les plis. Afin de limiter la proportion de polypes manqués, différentes approches ont été développées. Parmi celles-ci, l’une des plus simple corres-pond à la la possibilité d’équiper le coloscope d’un capuchon distal afin de déplisser les haustrations coliques et augmenter la surface de muqueuse vue lors du retrait. Néanmoins, le matériel à utiliser reste débattu, notamment en raison des résultats hétérogènes des études réalisées à ce jour.
Chemische Grundlagen der Lebensvorgänge: Eine Einführung in biologische Lehrbücher.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re: Randomized Controlled Trial to Evaluate Transdermal Testosterone in Female Cancer Survivors With Decreased Libido: North Central Cancer Treatment Group Protocol N02C3
Authors: B. Jones, S. Haughie
Journal: JNCI Journal of the National Cancer Institute (2008)

Treatment Group Protocol N02C3Barton et al. ( 1 ) presented the results of the analyses of various endpoints from a twoperiod crossover trial to compare active drug and placebo for the treatment of loss of libido in female cancer survivors.The authors stated that they had used a methodology for their analyses that "encompasses the state of the science for crossover studies."However, the results given in their table 2, and the subsequent conclusions made, are clearly not based on the correct crossover trial analyses.The correct methodology is described in Chapter 2 of the book by Jones and Kenward ( 2 ).Curiously, it is stated by Barton et al. that they have followed such methodology, referring to it in their article as the "sums and differences" analysis.However, what the authors have reported in their table 2 are P values for the comparison of drug and placebo in each period.Such comparisons are based on the variability between subjects and are therefore not correct for the analysis of a crossover trial.The correct analysis is based on the within-subject differences between the second and fi rst period measurements [see Section 2.3 of ( 2 )].The authors also advocate using the test for a carryover difference as a preliminary test for deciding if the test for drug vs placebo should be based either 1) on only the data from the fi rst period or 2) on the data from both periods.This procedure is seriously fl awed, as pointed out by Freeman ( 3 ) and further illustrated in Section 2.7 of ( 2 ).
Antibodies to Toluene Diisocyanate in an Environmentally Exposed Population
Authors: Kenneth G. Orloff, Dahna Batts-Osborne, Theresa Kilgus, Susan Metcalf, Mimi Cooper
Journal: Environmental Health Perspectives (1998)

Residents living near a polyurethane foam manufacturing facility expressed concern to health officials over chemical emissions from the plant. Environmental monitoring of ambient air near the plant indicated the presence of toluene diisocyanate (TDI), which was used in foam production. Health officials collected blood samples from 113 residents and analyzed the blood sera for antibodies to TDI and related diisocyanates. Ten of the 113 residents (9%) had elevated levels of IgG or IgE antibodies specific for one or more diisocyanates. Exposure histories were taken from antibody-positive individuals to identify possible occupational exposure to TDI or the use of diisocyanate-containing consumer products. Exposure to TDI in ambient air may be responsible for the positive antibody responses detected in some residents of the community.
Treatment of pre-established subcutaneous tumor and pulmonary melanoma metastasis with a novel vaccine expressing α(1,3)Galactosyl Xenoepitopes
Authors: G. R. Rossi, R. C. Unfer, M. R. Ackermann, T. Seregina, C. J. Link
Journal: Journal of Clinical Oncology (2004)

2620 Background: The hyperacute immune response in humans is a potent mechanism of xenograft rejection mediated by complement-fixing natural antibodies recognizing α(1,3)Galactosyl epitopes (αGal) not present on human cells. We exploited this immune mechanism to create a whole cell cancer vaccine to treat melanoma tumors. Methods: Transduction of B16 melanoma cells with a retrovirus carrying the α(1,3)Galactosyltransferase gene (αGT) yielded B16αGal cells. Transduction with a retrovirus carrying the gene for neomycin gave B16NeoR cells. Whole cell vaccines were prepared by γ-irradiation (200 Gy). Results: B16 melanoma vaccine expressing αGal epitopes (B16αGal) effectively treated pre-established subcutaneous and pulmonary B16 tumors in the α(1,3)Galactosyltransferase knockout mouse model, while control B16 melanoma vaccines had no effect. Vaccination with B16αGal induced strong long-lasting cell-mediated anti-tumor immunity extended to αGal-negative B16 melanoma. This was demonstrated by specific in vitro recognition of B16 cells, and successful adoptive transfer of immunity to recipient mice bearing lung melanoma metastasis. Conclusions: This study unequivocally establishes for first time the efficacy of whole cell vaccines expressing αGal epitopes against poorly immunogenic, preestablished melanoma. These data formed the basis for the initiation of this therapeutic strategy in human clinical trial currently underway. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration NewLink Genetics NewLink Genetics NewLink Genetics Funded by NewLink Genetics Corporation through a cooperative research and development agreement
Erythropoietin Therapy
Authors: Lawrence T. Goodnough, Terri G. Monk, Gerald L. Andriole
Journal: New England Journal of Medicine (1997)

Despite impressive advances in the safety of the blood supply,1 the search for therapeutic alternatives to blood continues.2,3 Erythropoietin (along with iron, vitamin B12, and folic acid) has been recommended as a specific medication "that should be used instead of blood transfusion if the clinical condition of the patient permits sufficient time for these agents to promote erythropoiesis."4 Therapy with recombinant human erythropoietin (Epogen, Amgen, Thousand Oaks, Calif.) was first shown to correct the anemia caused by chronic renal failure in patients undergoing dialysis.5 Subsequently, erythropoietin (Procrit, OrthoBiotech, Raritan, N.J.) was also approved for the treatment of . . .
The Archives of Pathology and Laboratory Medicine and the autopsy
Authors: G. D. Lundberg
Journal: JAMA (1984)

Following the successful negotiation of a contract between the American Medical Association and one of its federation members, the College of American Pathologists (CAP), a new version of the<i>Archives of Pathology and Laboratory Medicine</i>began to be published as a cooperative effort in January 1984. The Archives continues to be owned and published by the AMA. All CAP members receive theArchivesas a membership benefit. The quality of paper, covers, and photographs has been improved. Twenty more pages of editorial content were added in each issue with a plan to emphasize laboratory use, systems, computers, information science, quality assurance, and laboratory management in addition to anatomic and clinical pathology of more traditional sorts. With this added distribution, the circulation is now 17,400, making the ARCHIVES the most widely circulated peer-reviewed pathology journal in the world. William W. McLendon, MD, of Chapel Hill, NC, is the new editor, replacing
Inhibition of cytochrome P-4502E1 by clomethiazole improves alcoholic liver disease in alcohol-dependent patients: a short-term, randomized, controlled clinical trial
Authors: Helmut Seitz, Sebastian Mueller, Hohmann Nicolas, Fabian Schroeder, Bernardo Moreira, Haidong Teng, Walter-Emil Haefeli, Thomas Bruckner
Journal: Journal of Hepatology (2020)
P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport
Authors: Michael Köttgen, Thomas Löffler, Christoph Jacobi, Roland Nitschke, Hermann Pavenstädt, Rainer Schreiber, Sebastian Frische, Søren Nielsen, Jens Leipziger
Journal: Journal of Clinical Investigation (2003)

Extracellular nucleotides are important regulators of epithelial ion transport. Here we investigated nucleotide-mediated effects on colonic NaCl secretion and the signal transduction mechanisms involved. Basolateral UDP induced a sustained activation of Cl– secretion, which was completely inhibited by 293B, a specific inhibitor of cAMP-stimulated basolateral KCNQ1/KCNE3 K+ channels. We therefore speculated that a basolateral P2Y6 receptor could increase cAMP. Indeed UDP elevated cAMP in isolated crypts. We identified an epithelial P2Y6 receptor using crypt [Ca2+]i measurements, RT-PCR, and immunohistochemistry. To investigate whether the rat P2Y6elevates cAMP, we coexpressed the P2Y1 or P2Y6 receptor together with the cAMP-regulated cystic fibrosis transmembrane conductance regulator (CFTR) Cl– channel in Xenopus oocytes. A two-electrode voltage clamp was used to monitor nucleotide-induced Cl– currents. In oocytes expressing the P2Y1 receptor, ATP transiently activated the endogenous Ca2+-activated Cl– current, but not CFTR. In contrast, in oocytes expressing the P2Y6receptor, UDP transiently activated the Ca2+-activated Cl– current and subsequently CFTR. CFTR Cl– currents were identified by their halide conductance sequence. In summary we find a basolateral P2Y6 receptor in colonic epithelial cells stimulating sustained NaCl secretion by way of a synergistic increase of [Ca2+]i and cAMP. In support of these data P2Y6 receptor stimulation differentially activates CFTR in Xenopus oocytes.
Correction
Journal: BMJ (1895)

avoidable illness of the principal, and at such a time it is not com- mendable for an assistant to try to make the utmost out of an employer's misfortune; besides, rather than pay an assistant locum tenens fees in addition to his salary, a principal would prefer to engage a locutm tenens to carry on his practice in conjunction with him.The above is what appears to be consonant with the ethics of the case, but it must not be forgotten that, from a legal point of view, our corre- spondent's positioni may be very different.When his principal became disabled, it was open for him at once to vary the terms of his contract; as he did not think fit to do so, the law might decide he has no claim for increased remuneration at all.A solicitor is the only person to advise him here.
泛皮肤癣菌 PCR
Authors: M. Walser, P.P. Bosshard
Journal: British Journal of Dermatology (2019)

皮肤癣菌是指可导致皮肤、毛发和指/趾甲感染(称作皮肤癣菌病或癣)的真菌。这类感染是最常见的皮肤疾病之一,而且在任何指定时间均影响高达20%的人群。目前皮肤癣菌病的实验室诊断仍是基于显微镜检查和培养。培养是指采集样本并使其在实验室中生长,而显微镜检查是指使用显微镜检查样本。这可能既繁琐又耗时(皮肤癣菌培养需要长达4周)。在这项瑞士的研究中,作者旨在确立一种简单、稳定和快速的检查方法,以此在 1 至 2天内检测样本中的皮肤癣菌。他们开发了一种称作聚合酶链反应 (PCR)检测的检查方法,其在试管中复制许多特异性皮肤癣菌DNA的复本,从而可能证明样本中是否存在该DNA。使用306个临床样本(指/趾甲、皮肤和毛发)通过与显微镜检查和培养结果比较对PCR检测进行了评估。PCR、培养和显微镜检查的灵敏性(正确鉴定的实际阳性比例)估计分别为96.9%、46.7%和91.4%,同时特异性(正确鉴定的实际阴性比例)估计分别为90.4%、98.7%和84.0%。这种新的检测显示出了极好的性能,而且较培养技术显著更快,因此其对诊断皮肤癣菌病很有前途。
Comments from the Past
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sudden Death
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P099: The Relation of Kidney Disease to Measures of Digital Arterial Tonometry in the Jackson Heart Study
Authors: Eric McClendon, Solomon Musani, Sushante Khaire, Herman Taylor, Ervin Fox
Journal: Circulation (2012)

Background: The presence of chronic kidney disease is greater in African Americans than in non-Hispanic whites. Though there is data to show a relation between endothelial dysfunction and end-stage kidney disease, the relation to mild and moderate chronic kidney disease (particularly in African Americans) is unclear. Methods and Results: Digital arterial tonometry was performed during Exam 2 and 3 of the Jackson Heart Study using the endoPAT2000. Data from digital arterial tonometry included baseline pulse wave amplitude (BPA) as a measure of endothelial tone and reactive hyperemic index (F-RHI) as a measure of endothelial function. For this study, the estimated glomerular filtration rate (eGFR) was calculated using the MDRD equation. Those participants with eGFR &lt; 60 ml/min/1.73m2 were defined as having CKD. Participants with eGFR &lt; 15 ml/min/1.73m2 were excluded from the analysis. Microalbuminuria in this study was defined as a urinary albumin:creatinine ratio ≥ 17mg/g in men and ≥ 25 mg/g in women. We compared the differences in least square means adjusted for age and sex, and adjusted for multiple traditional clinical covariates using a generalized linear model. Results: There were 834 participants in the study population (mean age 58.5 years, 61% women); 87 (10.4%) participants with CKD and 108 (13.0%) with microalbuminuria. In age and sex adjusted samples, we found that both BPA and F-RHI were significantly associated with CKD in the pooled samples. However in multivariable adjusted analysis the relation was no longer significant in either the pooled or sex-specific samples. In the multivariable adusted analysis,BPA was significantly (P=0.036) associated with microalbuminuria in men and F-RHI was weakly significantly (P=0.08) associated with microalbuminuria in women. Conclusion: We found that endothelial dysfunction as measured by digital arterial tonometry is not significantly associated with chronic kidney disease. There is an association of endothelial tone in men and endothelial dysfunction in women with microalbuminuria.
THE NEW PHYSIOLOGIC SURGERY ON THE HEART
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal