tbuckley/cabot-search huggingface dataset:
Continued Antibiotic Use in Pregnancy Supported
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of topical calcipotriol on congenital ichthyoses
Authors: G.P.H. Lucker, P.M. Steijlen, P.C.M.van de Kerkhof
Journal: British Journal of Dermatology (1995)

Journal Article Effect of topical calcipotriol on congenital ichthyoses Get access G.P.H. Lucker, G.P.H. Lucker Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar P.M. Steijlen, P.M. Steijlen Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar P.C.M.van de Kerkhof P.C.M.van de Kerkhof Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 3, 1 March 1995, Page 487, https://doi.org/10.1111/j.1365-2133.1995.tb08695.x Published: 01 March 1995
Announcement Spotlight Issue on Cardiac Protection by Pre- and Postconditioning
Journal: Cardiovascular Research (2005)

A Spotlight Issue on Cardiac Protection by Pre-and Postconditioning is scheduled to appear in May, 2006.Preconditioning protects myocardial tissue through adaptive mechanisms exerted primarily during ischemia.However, postconditioning, by the very nature of its application at the onset of reperfusion, exerts protection during very early reperfusion.Signaling mechanisms and the degree of protection with respect to endothelial dysfunction, local inflammatory responses, infarction, and apoptosis are similar between the two cardioprotective strategies.Postconditioning not only confers great therapeutic promise but also sheds new light on the nature of reperfusion injury.Preliminary topics of invited review articles related to pre-and postconditioning include:
Translational Highlights from The Endocrine Society Journals
Journal: Endocrine Reviews (2012)

Polycystic ovarian syndrome (PCOS) is a heterogeneous syndrome associated with follicle growth arrest, minimal granulosa cell proliferation, dysregulated sex hormone profile, hyperthecosis, and insulin resistance.Using a 5␣-dihydrotestosterone (DHT)-induced rat model that recapitulates the reproductive and metabolic phenotypes of human PCOS, we have examined the steroidogenic capability of granulosa cells from DHT-treated rats.Gene expression of several key steroidogenic enzymes including p450 sidechain cleavage enzyme (p450scc), aromatase, steroidogenic acute regulatory protein, hydroxysteroid dehydrogenase-17␤, and hydroxysteroid dehydrogenase-3␤ were markedly lower in DHT-treated rats than the controls, although the responsiveness of their granulosa cells to FSH was higher.Expression of the adipokine chemerin and its receptor, chemokine receptor-like 1, was evident in control and DHT-treated rats, with significantly higher ovarian mRNA abundances and protein contents of chemerin and its receptor.Recombinant chemerin decreases basal estradiol secretion in granulosa cells from DHT-treated rats.When the inhibitory role of chemerin on steroidogenesis was further examined in vitro, chemerin suppressed FSH-induced progesterone and estradiol secretion in cultured preantral follicles and granulosa cells.Chemerin also inhibits FSH-induced aromatase and p450scc expression in granulosa cells.Overexpression of nuclear receptors NR5a1 and NR5a2 promotes p450scc and aromatase expression, respectively, which is suppressed by chemerin.These findings suggest that chemerin is a novel negative regulator of FSH-induced follicular steroidogenesis and may contribute to the pathogenesis of PCOS.
Sensitivity, specificity, and predictive values in the 'sensitivity and specificity of clinical diagnostics'
Authors: Bradley A. Woodruff, Roy C. Baron
Journal: JAMA (1989)

<h3>To the Editor.—</h3> The measures of accuracy in clinical screening or diagnosis relate to the intrinsic ability of a procedure to identify correctly those persons with disease (sensitivity) and those persons without disease (specificity).<sup>1</sup>In a recent article entitled "The Sensitivity and Specificity of Clinical Diagnostics During Five Decades,"<sup>2</sup>the authors use the<i>terms clinical accuracy for a positive diagnosis and clinical accuracy for a negative diagnosis</i>and equate them by definition to the positive predictive value (the proportion of positive tests or diagnoses that correctly identify the presence of disease) and the negative predictive value (the proportion of negative tests that correctly identify the absence of disease), respectively. Unlikesensitivity and specificity, the predictive values are not properties inherent to the procedure itself, but vary with the prevalence of disease in the population tested. For example, the authors state that "the accuracy of the clinical diagnosis
p38/MKP-1–regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair
Authors: Eusebio Perdiguero, Pedro Sousa-Victor, Vanessa Ruiz-Bonilla, Mercè Jardí, Carme Caelles, Antonio L. Serrano, Pura Muñoz-Cánoves
Journal: The Journal of Experimental Medicine (2011)
Amebic Balanitis
Authors: Roger B. Rodrigue
Journal: JAMA (1978)

<h3>To the Editor.—</h3> The BRIEF REPORT on amebiasis (238:1386-1387, 1977) discusses venereal transmission in homosexuals. In 1964 Cooke and I<sup>1</sup>reported on amebic balanitis and found that in an uncircumcised population studied in New Guinea, the disease produced a characteristic clinical disease with edema of the prepuce, phimosis, and a discharge of pus that appeared to come from the urethra but in fact came from around the glans penis.<i>Entamoeba histolytica</i>was present in large numbers in smears taken and examined microscopically. In untreated patients the disease produced a dehiscence of the prepuce, and the glans penis protruded through the prepuce. Misdiagnosis and treatment of these cases with penicillin as for gonorrhea produced no response, while both circumcision alone and antiamebic medications produced healing of the lesion. From this observation, it would appear that the uncircumcised penis does get infected. However, mechanical transfer of infective organisms can still take
Informed Consent
Authors: ANTHONY BOHAN
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 January 1984Informed ConsentANTHONY BOHAN, M.D., J.D.ANTHONY BOHAN, M.D., J.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-164_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: As both a physician and attorney, I was interested in the article by Lidz and associates (1) on informed consent. The authors clearly described the limitations of "informed" consent in the context of a university teaching hospital, pointing out that perhaps only 10% of their patients "saw themselves as having an active role in decision making." This conclusion is unfortunately likely to be accurate, given the diffusion of responsibility inherent in a university teaching service where the patient's physician is a team of interns, residents, fellows, and attending physicians.Historically, the doctrine of informed consent received one...Reference1. LIDZMEISELOSTERWEISHOLDENMARXMUNETZ CAMJJM. Barriers to informed consent. Ann Intern Med. 1983;99:539-43. LinkGoogle Scholar1. LIDZMEISELOSTERWEISHOLDENMARXMUNETZ CAMJJM. Barriers to informed consent. Ann Intern Med. 1983;99:539-43. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ANTHONY BOHAN, M.D., J.D.Affiliations: 320 Superior, Suite 340; Newport Beach, CA 92663 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPOrganic electrosyntheses in industryReducing malpractice liability exposure through better patient education 1 January 1984Volume 100, Issue 1Page: 164-165KeywordsDecision making ePublished: 1 December 2008 Issue Published: 1 January 1984 PDF downloadLoading ...
PBB Homologs in Sera of Michigan Dairy Farmers and Michigan Chemical Workers
Authors: Mary S. Wolff, Bertrand Aubrey
Journal: Environmental Health Perspectives (1978)

In November, 1976 the Environmental Sciences Laboratory of the Mount Sinai School of Medicine, examined 1029 persons in Michigan for the potential health effects of exposure to PBB. Included in this group were 55 persons from Michigan Chemical Corporation and 237 farming families. Blood serum was analyzed for PBB. FireMaster FF-1 contains several bromobiphenyl components, the major constituent being approximately 60% 2,4,4,2'4'4'-hexabromobiphenyl. Other PBB homologs identifiable as peaks by gas chromatography--mass spectrometry include two pentabromobiphenyl peaks, three additional hexabromobiphenyl peaks, and two heptabromobiphenyl peaks. The relative concentrations, with respect to the major hexabromobiphenyl peak, of these minor constituents (1--20%) of PBB were different for persons from Michigan Chemical Corporation and for farmers. Penta-, hexa-, and hepta-bromobiphenyl components in serum samples analyzed from farming families from Michigan Chemical Corporation employees were compared with relative concentrations of these homologs in FireMaster mixture and in tissue and blood samples from rats fed FireMaster FF-1. Varying concentrations of these PBB components are attributed to different routes of exposure and the relative ease of metabolism and excretion of one pentabromobiphenyl component.
Fiberoptic bronchoscopy in bacteriologic assessment of lower respiratory tract secretions. Importance of microscopic examination
Authors: F. E. Flatauer
Journal: JAMA (1980)

Use of fiberoptic bronchoscopy to acquire pulmonary secretions has been shown to yield unreliable bacterial cultures. However, microscopic examination of such material has received little attention. In this study, 69 bronchoscopies were evaluated. Clinical assessment of the presence of a lower respiratory tract infection was made and cultures obtained. In addition, each specimen was analyzed with a Gram-stained smear. The Gram-stained smears of these specimens correlated extremely well with the clinical assessment. In 67 of the 69 cases, bronchoscopy yielded material whose Gram-stained smear accurately reflected the presence or absence of a pyogenic infection. In patients with lower respiratory tract infections, the smear also predicted the likely category of the causative organism. This study suggests that microscopic examination of lower respiratory tract secretions helps make fiberoptic bronchoscopy a potentially useful alternative in the evaluation of bacterial lung infections. (<i>JAMA</i>244:2427-2429, 1980)
PREGNANCY, ESTROGENS AND HEPATIC IMPAIRMENT
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An algorithm for the operational assessment of adverse drug reactions. II. Demonstration of reproducibility and validity
Authors: T. A. Hutchinson
Journal: JAMA (1979)

The reproducibility and validity of an algorithm for diagnosis of adverse drug reactions (ADRs) were tested in a clinical spectrum of 30 suspect cases. Using a questionnaire derived from the algorithm the three algorithm developers (nonexperts) agreed on the probability of ADR in 67% of cases, with pair-wise agreement varying from 73% to 87%. The pair-wise agreement of two clinical pharmacologic experts rose from 47% without the algorithm to 63% with the algorithm, with K<sub>w</sub>, a chance-corrected index of weighted agreement, increasing from 0.26 to 0.57. The algorithmic assessments of the three nonexperts agreed with expert consensus in 80% to 83% of cases. The ADR algorithm appears to provide a reproducible and valid method of evaluating the likelihood of ADRs in individual patients. Its use can help improve the diagnostic and epidemiologic approach to these important, complex clinical phenomena. (<i>JAMA</i>242:633-638, 1979)
European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition – Quality assurance in pathology in colorectal cancer screening and diagnosis
Authors: P. Quirke, M. Risio, R. Lambert, L. von Karsa, M. Vieth
Journal: Endoscopy (2012)

Multidisciplinary, evidence-based guidelines for quality assurance in colorectal cancer screening and diagnosis have been developed by experts in a project coordinated by the International Agency for Research on Cancer. The full guideline document covers the entire process of population-based screening. It consists of 10 chapters and over 250 recommendations, graded according to the strength of the recommendation and the supporting evidence. The 450-page guidelines and the extensive evidence base have been published by the European Commission. The chapter on quality assurance in pathology in colorectal cancer screening and diagnosis includes 23 graded recommendations. The content of the chapter is presented here to promote international discussion and collaboration by making the principles and standards recommended in the new EU Guidelines known to a wider professional and scientific community. Following these recommendations has the potential to enhance the control of colorectal cancer through improvement in the quality and effectiveness of the screening process, including multi-disciplinary diagnosis and management of the disease.
Immunohistochemical localization of cathepsin D in regenerative and neoplastic liver lesions Depts. of Pathology, New York University and *Mount Sinai Medical Centers, NY NY
Journal: Hepatology (1995)

Background/Aims: The pathway through which iron contributes to liver cell damage and cirrhosis in genetic hemochromatosis is not clear. The objective of the present study was to describe the ultrastructural changes in liver biopsies of patients in various stages of this condition and to correlate these with clinical, histopathological and biochemical data.Methods: Liver biopsies from 20 patients with genetic hemochromatosis were examined by transmission electron microscopy. The use of unstained thin (60 nm) sections facilitated the identification and localization of the electron-opaque compounds of ferritin and hemosiderin in various liver cells. Stained thin sections permitted evaluation of the concomitant subcellular damage and collagen deposition. The ultrastructural observations were corroborated with the histopathological findings and biochemical data.Results: All patients had liver iron overload, which was classified as mild, moderate or severe. In the stage of mild overload (hepatic iron concentration HIC 93.5±23.3 μmol/g and hepatic iron index HII 2.3±0.7), cytosolic ferritin and scarce pericanalicular lysosomes (siderosomes) were seen in periportal hepatocytes (acinar zone 1), without evidence of organelle damage, and in the absence of sinusoidal cell siderosis. In moderate overload (HIC 190.8± 41.5 μmol/g and HII 4.3±1.9), ferritin was identified in hepatocytes of all acinar zones, and the pericanalicular siderosomes were abundant, especially in acinar zone 1. Single hepatocytes showed organelle damage and occasional sinusoidal cells showed siderosis. In severe overload (HIC 308±49.0 μmol/g and HII 7.5±1.7), hepatocytes of all acinar zones were-filled with large, hemosiderin-containing siderosomes, and changes in mitochondria, smooth and rough endoplasmic reticulum and nuclei were conspicuous. Marked sinusoidal cell siderosis and collagen deposition were observed predominantly in this stage.Conclusions: Electron microscopy has shown that during the long, latent stage of “compensated” genetic hemochromatosis, hepatocytes display only minimal subcellular changes, other than iron overload. “Decompensated” overload, characterized by extensive subcellular pathology and focal necrosis, is reached when 1) the hepatocytic siderosis is generalized (i.e. beyond pericanalicular polarization of siderosomes in hepatocytes, and beyond zone 1 in the acinus); and 2) there is evidence of massive siderosis of sinusoidal cells. These findings support the concept of a critical level of hepatic iron concentration beyond which organelle damage is conspicuous and liver cell injury may become irreversible.
Journal of Pharmacy and Pharmacology, London
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Can ultrasonic strain rate imaging quantify the changes in systolic function during dobutamine infusion, B-blockade, and atrial pacing? An experimental study Frank Weidemann, Fadi Jamal, Tomasz Kukulski, Bart Bijnens, Ivan De Scheerder, Liv Hatle, George R. Sutherland. Cardiology Department, University Hospital Gasthuisberg, Leuven, Belgium
Journal: Journal of the American College of Cardiology (2001)
Progress in Ophthalmic Surgery
Authors: John H. Dunnington, Ellen F. Regan, Francis A. L'Esperance
Journal: New England Journal of Medicine (1963)

RetinaDuring the past decade there has been outstanding progress in retinal-detachment surgery. Although all problems have not been solved the surgical results are steadily improving. In the light of these operative successes, every case of idiopathic retinal detachment should be treated surgically. Furthermore, the frequency with which the fellow eye becomes similarly affected is a strong argument for advising operation upon all retinal detachments except those associated with vascular anomalies or uveal inflammation. Even in the presence of these conditions surgery may have to be considered.The basic principles and objectives for successful reapposition of the retina were slowly . . .
The Cover
Authors: M. Therese Southgate
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRAINED NURSES IN THE COUNTRY
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal