tbuckley/cabot-search huggingface dataset:
EXTENDING AN OPERATION WITHOUT CONSENT.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Childhood Antecedents of Exposure to Traumatic Events and Posttraumatic Stress Disorder
Authors: Carla Storr
Journal: American Journal of Psychiatry (2007)

Objective: The authors prospectively examined childhood antecedents of exposure to traumatic events to estimate the risk of posttraumatic stress disorder (PTSD) among those exposed to trauma. Method: Two consecutive cohorts of children entering first grade of a public school system in a large mid-Atlantic city in the mid-1980s were followed into young adulthood (mean age=21). Exposure to traumatic events and PTSD were assessed in 75% of the original cohort (N=1,698). Childhood assessments, conducted upon entry into the first grade, included standardized measures of reading readiness, teacher ratings of behavioral problems, and child self-reports about depression and anxiety. Family characteristics were assessed by parental report. Results: Young adults who had been rated by their first grade teacher as having aggressive/disruptive behavior problems were more likely to experience traumatic assaultive violence events (e.g., being mugged/threatened with a weapon, badly beaten-up) (relative risk=2.6) but not PTSD following trauma exposure. Youths with high levels of self-rated depressive and anxious feelings in first grade were more likely to experience PTSD once exposed to trauma (relative risk=1.5). Youths who scored in the highest quartile on a reading test in the first grade were at lower risk for exposure to assaultive violence traumas. Conclusions: Childhood behavioral and depressive/anxious problems may influence the risk for PTSD directly by increasing the vulnerability to the PTSD effects of trauma exposure, and indirectly by increasing the likelihood of exposure to assaultive violence.
Safety and effectiveness of predeposit autologous transfusions in preteen and adolescent children
Authors: A. J. Silvergleid
Journal: JAMA (1987)

Although there is documentation in the literature of the safety and effectiveness of predeposit autologous transfusions among adult patients contemplating surgery, there are no comparable data for preteen and teenage children. We report our experience with 180 children between the ages of 8 and 18 years participating in a community blood center—based predeposit autologous transfusion program. Children as young as 8 years old and weighing as little as 27 kg predonated a prescribed amount of blood prior to elective orthopedic (169) or plastic (11) surgery. Only four children experienced a donor reaction; none of them was severe. No child was unable to donate the prescribed number of units. Eighty-eight percent of the children were able to supply their complete blood requirements, thus avoiding exposure to homologous blood. Our experience documents both the safety and effectiveness of predeposit autologous transfusions in preteen and adolescent children and should encourage existing predeposit autologous transfusion programs to extend participation to thousands of children for whom the opportunity to use their own blood is currently denied. (<i>JAMA</i>1987;257:3403-3404)
Graphataxia
Authors: Selim R. Benbadis
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 August 1990GraphataxiaSelim R. Benbadis, MDSelim R. Benbadis, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-3-257_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Graphataxia signifies incoordination of writing. It is extremely common but, despite its evident anomalous nature, has raised little interest. It is characterized by the use of a mixture of capital and lower case letters within the same text with a definite lack of consistency. By examining handwritten documents (medical charts, scrap notes, etc.), the clinician will encounter the following three stages. Stage 1: Mixture of capitals and lower cases in the same text. One or several given letters are consistently capitalized, even when they appear in the middle of a word. Stage 2: Here the same letter... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland Clinic Cleveland, OH 44122-0249 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1990Volume 113, Issue 3Page: 257-257KeywordsAtaxiaCharts Issue Published: 1 August 1990 PDF DownloadLoading ...
Human Biomonitoring: Research Goals and Needs
Authors: William A. Suk, Gwen Collman, Terri Damstra
Journal: Environmental Health Perspectives (1996)

Epidemiological studies have taken advantage of a number of strategies to monitor human populations for mortality, incidence, and exposure to hazardous environmental agents.These studies have been compromised by the lack of individual exposure assessment data that precisely quantifies internal dose.As methods improve in analytical chemistry and molecular biology, direct biological monitoring of exposed populations is possible.Biomarkers have been developed and validated in exposed populations that quantify individual exposure, susceptibility, and early markers of health effects and can be used to study relationships between exposures and environmentally induced diseases.This paper provides background on the state of the art of human populations monitoring and, through a series of case studies, provides examples of novel biomarkers of exposure, susceptibility, and effect that highlight new opportunities for biomoni toring.Prevention of human disease due to environmental contaminants can be accomplished by implementing strategies such as those discussed to monitor exposures and early health effects in human populations.
Masthead
Authors: Philip Aisen, York Bronx, North Sawkat Anwer, Gilbert Grafton, Maryland Bethesda, St Bacon, William Louis, Margaret Balistreri, Newcastle-Upon-Tyne Bassendine, D Montgomery Bissell, San Francisco, Andres Blei, Gunter Blobel, New York, Henry Bodenheimer, Jaime Bosch, Raymond Burk, Susan Burwen, David Carr-Locke, James Darnell, York Nicholas, Roger Davidson, Adrian Davis, Mae Anna, Maryland Diehl, Jeffrey Friedman, Scott Friedman, Hans Fromm, D Washington, Roberto Govindarajan, West Groszmann, Philip Haven, Virginia Richmond, Murray Heimberg, Steven James, Maryland Dean, P Jones, Georgia Jones, Maryland Kaplowitz, Los Angeles, Michael California
Journal: Hepatology (1991)
Abstract 4506: MDM2 alternative splicing is regulated by microRNA binding to control p53 activity
Authors: Matias Montes, Andrew Goodwin, Dawn S. Chandler
Journal: Cancer Research (2019)

Abstract Alternative splicing of the MDM2 is an important means by which p53 is upregulated to combat the deleterious effects of genotoxic stress. One splice variant, MDM2-ALT1, is activated in response to genotoxic stress and is comprised of only the two terminal coding exons 3 and 12 and therefore lacks a p53 binding domain. This variant has been identified in a number of human tumors, including invasive carcinoma of the breast and lung, as well as soft tissue sarcomas. Despite its pervasiveness in tumors and the therapeutic possibilities it presents, there is very little known about the regulators of that govern this alternative splicing event. Our lab has identified a specific microRNA that is expressed at high levels in normal cells but decreased under conditions of genotoxic stress and in rhabdomyosarcoma cells, both of which are characterized by the expression of the MDM2 spliced isoform. Hence, expression of the microRNA is inversely correlated with the splice variant MDM2-ALT1. Though recent studies have shown that splicing factors can be regulated through miRNA-mediated gene silencing and indirectly influence splicing choices, we were unable to identify any splicing regulators of MDM2 to be targeted by the microRNA. Interestingly, the microRNA has been reported as one of the miRNAs that is reimported to the nucleus but has not been ascribed a role in the nuclear space. We therefore wanted to test the hypothesis that the microRNA can directly bind to the MDM2 pre-mRNA to drive splicing choices in a regulated fashion. To this end, we have identified predicted binding sites for the microRNA in the regulated region of MDM2, within and near exons 3 and 12. We have shown that the microRNA binds specifically to these regions in MDM2 in normal cells and has decreased binding after genotoxic stress. Furthermore, we have shown that overexpression of the pre-microRNA can alleviate the induction of the MDM2-ALT1 isoform in response to genotoxic stress. We propose that microRNA binding to the MDM2 pre-mRNA regulates its splicing and plays a role in the DNA damage response and the pathway to tumorigenesis. Our work implicates for the first time that a miRNA would be acting as a splicing factor, a novel function for this class of non-coding RNAs and a novel method of regulation of the p53-MDM2 axis. Furthermore, our discoveries reveal miR-regulated splicing as a possible strategy to activate p53 and sensitize cancer cells to conventional cancer therapies. Citation Format: Matias Montes, Andrew Goodwin, Dawn S. Chandler. MDM2 alternative splicing is regulated by microRNA binding to control p53 activity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4506.
Hormonal Contraception and Its Association With Depression—Reply
Authors: Charlotte Wessel Skovlund, Lina Steinrud Mørch, Øjvind Lidegaard
Journal: JAMA Psychiatry (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Abstract 038: Association of 20-Year Changes in Cardiorespiratory Fitness with Incident Dyslipidemia Between Years 20 and 25 in the CARDIA Fitness Study
Authors: Mark A Sarzynski, Barbara Sternfeld, Mercedes R Carnethon, Stephen Sidney, Charles P Quesenberry, William L Haskell, David R Jacobs, Cora E Lewis, Pamela J Schreiner, O. D Williams
Journal: Circulation (2013)

Cardiorespiratory fitness levels are inversely associated with plasma levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) and directly associated with high-density lipoprotein cholesterol (HDL-C) levels. However, few population-based studies have examined the association of fitness or changes in fitness on the risk of developing dyslipidemias. PURPOSE: To test the association of fitness at age 18-30 years with 25-year incidence of dyslipidemias, and to test the association of fitness changes over 20 years on the development of dyslipidemias in adults aged 43-55 years. METHODS: Fitness was determined based on the duration of a symptom-limited graded exercise treadmill test (modified Balke protocol) at baseline and Year 20 in Black and White men and women from the Coronary Artery Risk Development in young Adults (CARDIA) study. Lipid measurements were taken from fasting samples at baseline and years 5, 7, 10, 15, 20, and 25. Dyslipidemias were defined as: low HDL-C = &lt;40 mg/dl, high TG = ≥200 mg/dl, and high LDL-C = ≥160 mg/dl (or self-reported use of lipid lowering medication). Cox proportional hazards regression models were used to test the association of baseline fitness with the incidence of dyslipidemias over 25 years (N ~4,000) in participants who did not have dyslipidemia at baseline. ANOVA modeling was used to test whether the mean 20-year changes in fitness differed between participants who developed incident dyslipidemia at Year 25 and those who did not (N= 2504). RESULTS: The 25-year incidence per 1000 person-years was 13.4 (N=1,096) for low HDL-C, 7.6 (N=711) for high TG, and 6.4 (N=569) for high LDL-C. Baseline fitness (SD 2.8 min) was inversely associated with 25-year incidence of low HDL-C (hazard ratio (HR): 0.94; 95% CI: 0.91 to 0.97 per SD in baseline fitness), high TG (HR: 0.90; 95% CI: 0.87 to 0.94 per SD), and high LDL-C (HR: 0.93; 95% CI: 0.89 to 0.97 per SD) in models that adjusted for age, sex, race, center, baseline BMI, and weight change and smoking status at time of event. After adjustment for age, sex, race, center, weight change, baseline treadmill time and BMI, participants who developed low HDL-C, high TG, and high LDL-C between Years 20 and 25 experienced larger 20-year declines in fitness than those who did not: (results shown as 20-year change in fitness in participants experiencing incident dyslipidemia at Year 25 vs participants who were normolipidemic at both time points) HDL-C: -3.1 vs -2.7 min, P=0.03; TG: -3.1 vs -2.8 min, P=0.004; LDL-C: -3.1 vs -2.8 min, P=0.04. CONCLUSIONS: Low fitness in young adults and larger decreases in fitness with aging are associated with the incidence of dyslipidemias.
New Rubella Test Reported
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Détection de la métaplasie intestinale et des lésions néoplasiques gastriques en endomicroscopie confocale: un essai multicentrique randomisé contrôlé
Journal: Endoscopy (2017)

Introduction: Du fait de l’aspect endoscopique peu distinctif de la métaplasie intestinale gastrique (MIG), de la néoplasie intra épithéliale (NIG) et du cancer gastrique précoce (CGP), un nombre significatif de lésions peuvent être manquées lors d’une endoscopie de surveillance. L’objectif de cet essai clinique était d’évaluer l’apport de la chromoendoscopie virtuelle (système intelligent de rehaussement des structures de Fujinon [FICE]) et de l’endomicroscopie confocale par mini-sonde (EMC) pour la détection in vivo de MIG, NIG et CGP.
DERMOTOME
Authors: G. L. Hagen
Journal: JAMA (1924)

In the surgical operation of transplanting skin from one person to another, it has been customary to use a razor in cutting the skin from the donor. Difficulty is experienced in cutting it of uniform thickness, the razor blade having a tendency to turn in the hand and cut deeper in one place than in another. It is desirable that the transplanting operation be performed without the flow of blood from the donor, and this can hardly be avoided when a razor is used, as uneven cuts are made in the flesh. The object of my invention is to provide an instrument by means of which a thin shaving of flesh may be removed of the desiredthickness, with provision to prevent accidental deep cutting and the consequent flow of blood. A further object is to provide an instrument by which the flesh may be cut and transplanted much more rapidly
Names for aneurysms
Authors: J. S. Yao
Journal: JAMA (1986)

<h3>In Reply.—</h3> Dr Yao raises the issue of the significance of the term "dissecting aneurysm." We find the following in<i>The Heart: Arteries and Veins</i><sup>1</sup>: It is important to recognize the distinct nature of this lesion. The term<i>dissecting aneurysm</i>is often applied but leads to confusion with an entirely separate problem—expanding or leaking aneurysm of atherosclerotic or luetic origin.<i>Aortic dissection</i>is a much more suitable label, particularly since aneurysm formation is not a feature of the acute phase. External rupture, by far the most common cause of death from aortic dissection, tends to occur at the site of the entrance tear. This validates my comments in the original book review that aortic dissections are primarily a disease of the thoracic aorta, while aneurysms are primarily a disease of the abdominal aorta. It is true that<i>late</i>aneurysm rupture may complicate thoracic aortic dissections; however, as noted above,
<i>Psychiatry, a Clinical Treatise on Diseases of the Fore-Brain, based upon a Study of its Structure, Functions and Nutrition</i>. By Theodore Meynert, M. D., Professor of Nervous Disease and Chief of the Psychiatric Clinic in Vienna. Translated (under authority of the author) by B. Sachs, M. D., Instructor in Diseases of the Mind and Nervous System in the New York Polyclinic. Part I. The Anatomy, Physiology, and Chemistry of the Brain. New York and London: G. P. Putnam’s Sons. 1885
Journal: American Journal of Psychiatry (1886)
Reference Committees—1979 Annual Convention
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE BÁRÁNY TESTS IN THE EXAMINATION OF AVIATORS
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beltsville Symposium on Virology in Agriculture
Journal: JNCI Journal of the National Cancer Institute (1975)

Beltsville Symposium on Virology in Agriculture Get access JNCI: Journal of the National Cancer Institute, Volume 55, Issue 6, December 1975, Page 1520, https://doi.org/10.1093/jnci/55.6.1520 Published: 01 December 1975
EDUCATION IN ENGLISH SCHOOLS
Journal: BMJ (1902)

In England state provision for economics education in schools has been negligible.Except for a marginal number of students opting to study economics at secondary level, the subject has been largely limited to implicit lessons in philanthropy through liberal activities such as fundraising for charity and the like.Now, however, New Labour has countered this neglect by adding Personal Financial Capability and Enterprise and Entrepreneurial Education to the statue book.This paper takes issue with both the implicit and explicit curriculum for economics education in an attempt to uncover its assumptions and critique underlying policy.
Corneal Disease
Authors: Jay H. Krachmer, David A. Palay
Journal: New England Journal of Medicine (1991)

The cornea is the main refractive element of the eye and the first tissue of the visual system that processes visual images. The cornea has three layers: the epithelium, the stroma, and the endothelium. The epithelium is four to six cell-layers thick and is composed of nonkeratinized, stratified squamous epithelium. The stroma constitutes 90 percent of the corneal thickness and is composed primarily of collagen and proteoglycans. The endothelium is one cell-layer thick and is responsible for removing fluid from the cornea, thereby preventing corneal edema. The cornea is approximately 12 mm in diameter and has a central thickness of . . .