tbuckley/cabot-search huggingface dataset:
Benefits of early intensive glucose control to prevent diabetes complications were sustained for up to 10 years
Authors: Eoin P. O’Sullivan
Journal: Annals of Internal Medicine (2008)

ACP Journal ClubDecember 16, 2008Benefits of early intensive glucose control to prevent diabetes complications were sustained for up to 10 yearsEoin P. O’Sullivan, MD, Sean F. Dinneen, MDEoin P. O’Sullivan, MDUniversity Hospital, Galway, Ireland (E.P.O.)Search for more papers by this author, Sean F. Dinneen, MDNational University of Ireland,, Galway, Ireland (S.F.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-12-200812160-02004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationHolman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577-89. https://pubmed.ncbi.nlm.nih.gov/18784090Clinical Impact RatingsGIM/FP/GP: Endocrinology: References1 UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-53. [PMID: 9742976] Google Scholar2 UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998;317:703-13. [PMID: 9732337] Google Scholar3 Patel A, MacMahon S, Chalmers J, et al, for the ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560-72. [PMID: 18539916] Google Scholar4 Gerstein HC, Miller ME, Byington RP, et al, for the Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358:2545-59. [PMID: 18539917] Google Scholar5 Nathan DM, Cleary PA, Backlund JY, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353:2643-53. [PMID: 16371630] Google Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital, Galway, Ireland (E.P.O.)National University of Ireland,, Galway, Ireland (S.F.D.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBenefits of tight blood pressure control to prevent diabetes complications were not sustained Eoin P. O’Sullivan and Sean F. Dinneen Metrics December 16, 2008Volume 149, Issue 12Page: JC6-4KeywordsAnginaBloodBlood plasmaBlood pressureCardiovascular disease riskDietEndocrinologyGlucoseGlycationHeart failureHemoglobinInsulinLipidsMyocardial infarctionOverweightPeripheral vascular diseaseProspective studiesStrokeType 2 diabetes ePublished: 10 March 2020 Issue Published: December 16, 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Service
Authors: Ranjana Srivastava
Journal: New England Journal of Medicine (2009)

This morning, I came upon an intern engrossed at the computer.“I am looking up the diseases Mr. Crosby died of,” she explained.The octogenarian had been on our unit for 4 weeks with multiorgan failure. His usually jovial nature had changed toward the end, and we all accepted that he had given up. I thought we had a good rapport with his family, though, so I was surprised by the intern's wariness.“Is there a problem?”“Not yet,” she said. “But you know what families can be like.”I didn't stay to argue the point, but her warning echoed . . .
The Relationship Between Physicians' Malpractice Claims History and Later Claims
Authors: Elliot Frank
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Messrs Bovbjerg and Petronis<sup>1</sup>present a cogent actuarial analysis of the relationship between physicians' malpractice claims history and subsequent claims. However, the most telling comment on the malpractice fiasco is their assertion that "malpractice claims remain relatively rare," a contention supported by the fact that during almost 9 years in continuous practice, 41% of the 8247 Florida physicians observed were targets of litigation. By whose standard is this rare? This pronouncement on the rarity of malpractice highlights the insensitivity of those outside the medical profession to the seriousness of lawsuits—the psychological toll they take on physicians, the erosion in a physician-patient relationship that they engender, and the tremendous costs in defensive medicine that they beget. Though lawsuits are not the focus of their article, the authors appear to trivialize them, especially those concluded without payment or with minimal outlay. This trivialization reflects either a callous indifference
HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction
Authors: I. Curjuric, M. Imboden, C. Schindler, S. H. Downs, M. Hersberger, S. L. J. Liu, G. Matyas, E. W. Russi, J. Schwartz, G. A. Thun, D. S. Postma, T. Rochat, N. M. Probst-Hensch
Journal: European Respiratory Journal (2009)

Reduced exposure to particulate matter with a 50% cut-off aerodynamic diameter of 10 μm (PM<sub>10</sub>) attenuated age-related lung function decline in our cohort, particularly in the small airways. We hypothesised that polymorphisms in glutathione <i>S</i>-transferase (<i>GST</i>) and haem oxygenase-1 (<i>HMOX1</i>) genes, important for oxidative stress defence, modify these beneficial effects. A population-based sample of 4,365 adults was followed up after 11 yrs, including questionnaire, spirometry and DNA blood sampling. PM<sub>10</sub> exposure was estimated by dispersion modelling and temporal interpolation. The main effects on annual decline in forced expiratory flow at 25–75% of forced vital capacity (FEF<sub>25–75%</sub>) and interactions with PM<sub>10</sub> reduction were investigated for polymorphisms <i>HMOX1</i> rs2071746 (T/A), rs735266 (T/A) and rs5995098 (G/C), <i>HMOX1</i> (GT)<sub>n</sub> promoter repeat, <i>GSTM1</i> and <i>GSTT1</i> deletions, and <i>GSTP1</i> p.Ile105Val, using mixed linear regression models. <i>HMOX1</i> rs5995098, <i>HMOX1</i> haplotype TTG and <i>GSTP1</i> showed significant genetic main effects. Interactions with PM<sub>10</sub> reduction were detected: a 10 μg·m<sup>−3</sup> reduction significantly attenuated annual FEF<sub>25–75%</sub> decline by 15.3 mL·s<sup>−1</sup> only in the absence of <i>HMOX1</i> haplotype ATC. Similarly, carriers of long (GT)<sub>n</sub> promoter repeat alleles or the <i>GSTP1</i> Val/Val genotype profited significantly more from a 10 μg·m<sup>−3</sup> reduction (26.5 mL·s<sup>−1</sup> and 27.3 mL·s<sup>−1</sup> respectively) than non-carriers. Benefits of a reduction in PM<sub>10</sub> exposure are not equally distributed across the population but are modified by the individual genetic make-up determining oxidative stress defence.
Beyond Diagnosis and Statistics
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Capillary abnormalities in polyvinyl chloride production workers. Examination by in vivo microscopy
Authors: H. R. Maricq
Journal: JAMA (1976)

Examination by wide-field capillary microscopy of the hands of 152 workers in vinyl chloride (VC) polymerization plants demonstrated scattered, scleroderma-like microvascular abnormalities in 21 workers and isolated capillary abnormalities in 27, as compared with only three isolated abnormalities in 50 manual workers not exposed to vinyl chloride. Thirteen of 17 VC workers with objective evidence of VC-associated abnormalities (angiosarcoma or fibrosis of liver, acroosteolysis, or scleroderma-like skin lesions) were observed to have microvascular abnormalities. If prospective studies confirm the implications of this study, capillary microscopy may become a useful mass-screening procedure in the early detection and prevention of VC-associated disease. (<i>JAMA</i>236:1368-1371, 1976)
MRI detection of atherosclerotic vulnerable plaque using super paramagnetic iron oxide (SPIO) contrast media Mitra Rajabi, Mohammed Asif, Michael Quast, Jingna Wei, Daniel Chen, Mohammad Madjid, Ward Casscells, James T. Willerson, Morteza Naghavi. University of Texas-Houston, Houston, TX, University of Texas-Medical Branch at Galveston, Galveston, TX
Journal: Journal of the American College of Cardiology (2001)
U.S. Sperm Trend: Response
Authors: John Heinze
Journal: Environmental Health Perspectives (1999)

ConclusionsThe letter written by Heinze (1) has seri- ous shortcomings.Heinze wrote that There is not a single study of healthy men from any fertility center or sperm bank that has reported a decline in sperm counts in the United States.This is not true.A number of such studies exist.Leto and Frensilli (2) documented a decline in sperm counts in potential sperm donors from all over the United States in a longitudinal study.Heinze stated thatA study by MacLeod and Wang (3) indicates that sperm counts have remained constant in New York since 1938.That study was dated 1979 and was on men ascertained at a fertility center.Although their sperm counts were stable over the years preceding 1979, it does not necessarily follow that sperm counts of fertile men were stable too.
Abstract 2990: Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
Authors: Xiaowen Zhang, Huai-Chin Chiang, Yao Wang, Chi Zhang, Victor X. Jin, Yanfen Hu, Rong Li
Journal: Cancer Research (2018)

Abstract Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it is unclear whether loss of these ubiquitously important functions fully explains the cell lineage-specific tumorigenesis. In vitro studies implicate BRCA1 in elimination of R-loops, DNA-RNA hybrid structures involved in transcription and genetic instability. Here we show that R-loops accumulate preferentially in breast luminal epithelial cells, not in basal epithelial or stromal cells, of BRCA1 mutation carriers. Furthermore, R-loops are enriched at the 5′ end of those genes with promoter-proximal RNA polymerase II (Pol II) pausing. Genetic ablation of Cobra1, which encodes a Pol II-pausing and BRCA1-binding protein, ameliorates R-loop accumulation and reduces tumorigenesis in Brca1-knockout mouse mammary epithelium. Our studies show that Pol II pausing is an important contributor to BRCA1-associated R-loop accumulation and breast cancer development. Citation Format: Xiaowen Zhang, Huai-Chin Chiang, Yao Wang, Chi Zhang, Victor X. Jin, Yanfen Hu, Rong Li. Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2990.
Preventable hospitalizations and access to health care
Authors: A. B. Bindman
Journal: JAMA (1995)

<h3>Objective.</h3> —To examine whether the higher hospital admission rates for chronic medical conditions such as asthma, hypertension, congestive heart failure, chronic obstructive pulmonary disease, and diabetes in low-income communities resulted from community differences in access to care, prevalence of the diseases, propensity to seek care, or physician admitting style. <h3>Design.</h3> —Analysis of California hospital discharge data. We calculated the hospitalization rates for these five chronic conditions for the 250 ZIP code clusters that define urban California. We performed a random-digit telephone survey among adults residing in a random sample of 41 of these urban ZIP code clusters stratified by admission rates and a mailed survey of generalist and emergency physicians who practiced in the same 41 areas. <h3>Setting.</h3> —Community based. <h3>Participants.</h3> —A total of 6674 English- and Spanish-speaking adults aged 18 through 64 years residing in the 41 areas were asked about their access to care, their chronic medical conditions, and their propensity to seek health care. Physician admitting style was measured with written clinical vignettes among 723 generalist and emergency physicians practicing in the same communities. <h3>Main Outcome Measures.</h3> —We compared respondents' reports of access to medical care in an area with the area's cumulative admission rate for these five chronic conditions. We then tested whether access to medical care remained independently associated with preventable hospitalization rates after controlling for the prevalence of the conditions, health care seeking, and physician practice style. <h3>Results.</h3> —Access to care was inversely associated with the hospitalization rates for the five chronic medical conditions (<i>R</i><sup>2</sup>=0.50;<i>P</i>&lt;.001). In a multivariate analysis that included a measure of access, the prevalence of conditions, health care seeking, and physician practice style to predict cumulative hospitalization rates for chronic medical conditions, both self-rated access to care (<i>P</i>&lt;.002) and the prevalence of the conditions (<i>P</i>&lt;.03) remained independent predictors. <h3>Conclusion.</h3> —Communities where people perceive poor access to medical care have higher rates of hospitalization for chronic diseases. Improving access to care is more likely than changing patients' propensity to seek health care or eliminating variation in physician practice style to reduce hospitalization rates for chronic conditions. (<i>JAMA</i>. 1995;274:305-311)
In Vivo Detection of Radicals in Biological Reactions
Authors: Britton Chance, G. Gao
Journal: Environmental Health Perspectives (1994)

In vivo detection of free radicals on a quantitative basis is essential for an establishment of their role in membrane, protein, and cell and tissue dam- age.This article compares optical methods, including chemiluminescence, electron paramagnetic resonance (EPR) and NMR methods for the study of free radicals and free radical damage, especially reperfusion injury neutrophil accumulation 6 hr after the ischemia/reperfusion insult.The chemilu- minescence method is applied to an evaluation of the improved resistance to free radical stress due to transfection of creatine kinase in the mouse
INSTRUMENT FOR USE IN PHOTOTHERAPY.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sequel to Hyaline Membrane Disease?
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stopping Smoking
Authors: CLAUDE A. FRAZIER
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 December 1973Stopping SmokingCLAUDE A. FRAZIER, M.D.CLAUDE A. FRAZIER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-6-914_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am currently editing a book on how to stop smoking. I would appreciate hearing about any methods that have been effective. Please contact me at the following address.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 4-C Doctor's Park Asheville, NC 28801 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1973Volume 79, Issue 6Page: 914-914KeywordsHearing Issue Published: 1 December 1973 PDF downloadLoading ...
Normal and Diabetic Patterns of Insulin Response to Glucose
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians and Patient Spirituality
Authors: John Graner
Journal: Annals of Internal Medicine (2003)

Letters15 April 2003Physicians and Patient SpiritualityJohn Graner, MDJohn Graner, MDMayo Clinic; Rochester, MN 55905 (Graner)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-8-200304150-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The majority of Dr. Baumgartner's letter pertains to the office display of gay-friendly posters, which is a subject entirely separate from that addressed in my letters published over the years. Obviously, one's sexual orientation is not the same as one's religious orientation. If he somehow thinks he is referring to anything I have said, Dr. Baumgartner is sparring with an imaginary partner when he states, The implication is that it is somehow correct for a homosexual physician to nonverbally communicate who he or she is through office adornments. I don't agree with this practice any more than I ... Author, Article, and Disclosure InformationAuthors: John Graner, MDAffiliations: Mayo Clinic; Rochester, MN 55905 (Graner) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDo Ask, Do Tell Jennifer E. Potter Physicians and Patient Spirituality Susan B. LeGrand Physicians and Patient Spirituality Fritz Baumgartner Metrics 15 April 2003Volume 138, Issue 8Page: 691KeywordsHomosexualsHuman sexual behavior ePublished: 15 April 2003 Issue Published: 15 April 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Spotlight Issue on Reactive Oxygen Species as Cardiovascular Signaling Molecules
Journal: Cardiovascular Research (2005)

A Spotlight Issue on Reactive Oxygen Species (ROS) is scheduled to appear in July, 2006.The tightly regulated, ROS-mediated modulation of signal transduction pathways plays important pathophysiological roles in cardiovascular disease.Recent work has illuminated several aspects of this field, including the regulation of ROS production, their molecular mechanisms of action and their specific involvement in conditions such as vascular and cardiac remodeling, atherosclerosis, hypertension, and inflammation.This Spotlight Issue aims to summarize the state of the art in this fast-moving field.Preliminary topics of invited review articles related to ROS in the cardiovascular system include: