tbuckley/cabot-search huggingface dataset:
P04.13 * EXPRESSION OF PLURIPOTENCY STEMNESS GENES IN HUMAN GLIOMAS OF DIFFERENT TUMOR GRADES BEFORE AND AFTER CHEMOTHERAPY
Authors: L. Dreher, G. Rohn, M. Perrech, R. Goldbrunner, M. Timmer
Journal: Neuro-Oncology (2014)

OBJECTIVE: Following the concept of glioma stem-like cells being the crucial reservoir for self-renewal, differentiation and proliferation of malignant brain tumors and escaping from adjuvant therapy numerous efforts have been made to exactly characterize them. However, several functional assays and analysis of surface markers to clearly identify this subgroup have led to insufficient and controversial results so far. Therefore we analyzed the expression levels of a bunch of potential markers of glioma stem-like cells in human glioma samples of different WHO grades and different treatment. We aimed not only to identify an adequate specific marker for stemness in human gliomas but also to gain insight into expression changes with increasing tumor grade and effects of chemotherapy on cancer stem cell activity. METHODS: cDNA was synthesized from mRNA of 80 snap frozen tumor samples from patients with gliomas of different tumor grades and pre-treatment (WHO grade II, III, secondary glioblastoma ± chemotherapy, primary glioblastoma ± chemotherapy, peritumoral tissue) and from 5 cell lines (U87, Gl36, HES2 (human embryonic stem cells), NPC (neuronal progenitor cells), hDF (human dermal fibroblasts)). Using quantitative real-time PCR relative expression levels of cMyc, Klf4, Nanog, Nestin, Oct4, and Sox2 were analyzed. Quantitative data were normalized in relation to the housekeeping gene SDHA. Results are depicted in mean ± SEM. RESULTS: The expression of Sox2 in all tested tumor groups was higher than in the control peritumoral tissue (2.10 ± 0.72). Interestingly highest expression levels were seen in WHO grade II (8.37 ± 1.60) and grade III (9.80 ± 2.20) tumor groups. cMyc, Nanog and Nestin expression were generally low compared to other tested genes in all tumor samples including control tissue, without any significant differences between the tumor grades and pre-treatment. Oct4 expression was high in all tested tumor groups (mean ranging from 7.5-57.77) compared to other genes. Remarkably Klf4 was lower expressed in two of the tested tumor groups compared to control tissue. CONCLUSIONS: We here provide expression profiles of different stemness genes in human tumors of different grades and treatment on genetic level. Interestingly, the transcription factor Sox2 seems to play a role especially in gliomagenesis as it is overexpressed in lower grade gliomas. At present we are completing our findings with biochemical methods (Western blot analysis).
Presidential disability and the twenty-fifth amendment
Authors: J. Sotos
Journal: JAMA (1995)

<h3>In Reply.</h3> —In response to the letter by Dr Lee, I did not imply that there was any floundering in the Bush administration regarding the disability and succession issue. Lee's letter raises two important points: (1) the American public likely does not understand the workings of the Twenty-fifth Amendment, and they would find it difficult to accept the concept of an acting president, and (2) the careful plans described by Lee are unknown to most of us. It is obvious they would have to be shorn of sensitive and security issues, but promulgation of the plans would be reassuring to the public.
REGISTRATION OF TUBERCULOSIS.Special meeting of the College of Physicians and Surgeons of Philadelphia, held Jan. 12, 1894, the President, S. Weir Mitchell, M. D., in the Chair.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enfermedades de los Intestinos.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROPRIETARY MEDICINES AND THE REVENUE STAMP.A CENSORSHIP FOR ARTICLES OF THE MATERIA MEDICA.JAMAICA-GINGER DRINKERS' AMBLYOPIA.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergy to laboratory animals in children of parents occupationally exposed to mice, rats and hamsters
Authors: A Krakowiak, B Szulc, P Gorski
Journal: European Respiratory Journal (1999)

Sensitization to laboratory animals (LA) has a high prevalence among laboratory workers. It is unknown whether transportation of LA allergens can be a risk factor for sensitization of subjects outside the laboratory environment. The aim of the study was to investigate the prevalence of sensitization to LA among children whose parents were and were not occupationally exposed to LA. The first group consisted of 50 children (age 12.3+/-4.3 yrs) whose parents were occupationally exposed to mice, rats and hamsters. The second group consisted of 40 children (age (mean+/-SD) 10.8+/-3.0 yrs) whose parents were not occupationally exposed to LA. Children having LA at home were eliminated from the study. All children responded to a questionnaire, underwent spirometry and were also tested with skin prick tests with the use of common allergens and prick tests with hair extracts from mouse, hamster and rat. Total immunoglobulin (Ig)E levels and the presence of specific IgE against LA were also estimated. Children of parents occupationally exposed to LA presented significantly more positive skin prick tests against allergens from the hair of laboratory animals compared to children of nonexposed parents. Five children from the first group were also found to have specific IgE against LA, with three of these five children complaining of rhinitis and cough while visiting their parents' workplace. It is concluded that the observed increased sensitization to laboratory animals among children of occupationally exposed parents could be the result of poor hygienic conditions at their parents' workplace. Hence, parents' job seems to be an additional risk factor of sensitization and should be taken into consideration when recording an allergic history.
THE CONFERENCE OF THE COUNCIL ON MEDICAL EDUCATION.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SECRET NOSTRUMS AND THE JOURNAL.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electron Beam Computed Tomography Detects Coronary Artery Disease in Fit Asymptomatic Middle-Aged Individuals
Authors: Jerel M Zoltick, Irwin M. Feuerstein, Michael P. Brazaitis, Mark A Vaitkus, William F Barko
Journal: Circulation (2001)

P25 Electron Beam Computed Tomography (EBCT) is used to detect coronary artery calcification (CAC), a marker of atherosclerosis. The EBCT was used to determine the presence of CAC in a population of very fit individuals. EBCT determined the calcification scores in 436 asymptomatic individuals (400 males 36 females, mean age 43.5±3.2 yrs, range 33 to 56 yrs). All underwent extensive cardiovascular and fitness evaluations including medical, fitness and nutritional histories; lipid profiles, fasting blood sugars, homocysteine, and lipoprotein(a) levels. Individuals underwent a physical examination, resting electrocardiogram, measurements of strength and flexibility, a maximal symptom-limited treadmill test, and a direct measurement of maximal oxygen consumption. CAC was detected by EBCT scan (3 mm thick, ECG-triggered, axial images) and quantified using the Agatston scoring technique. EBCT scores ranged from 0 to 2112 and were classified into standard categories - insignificant atherosclerosis: calcium &lt;10 (n=364 83.3%); mild atherosclerosis: calcium 10-99 (n=31 13.5%); moderate atherosclerosis: calcium 100-399 (n=7 1.6%); and marked atherosclerosis: calcium &gt;399 (n=7 1.6%). CAC was more likely in individuals who had an elevated LDL-Chol level (p≤.001) and CHOL/HDL ratio (p≤.001), but there was wide variance. Factors that had little or no correlation included fitness parameters as determined by strength measurements, aerobic capacity or bodyfat determination. Individuals with family history of early CAD had tendency for the development of CAC but again there was wide variation in the severity of the calcium score. Of the four individuals who had CAC scores over 1000, two subsequently sustained a myocardial infarction despite previous normal maximal exercise treadmill tests. In this group exercise thallium studies were not predictive for future events. It is difficult to detect CAD in fit, asymptomatic middle-aged individuals. EBCT is helpful in defining a high risk CAD group that is not readily determined by standard risk factors.
Seventh International Convocation on Immunology
Journal: JNCI Journal of the National Cancer Institute (1979)

Seventh International Convocation on Immunology Get access JNCI: Journal of the National Cancer Institute, Volume 63, Issue 6, December 1979, Page 1493, https://doi.org/10.1093/jnci/63.6.1493-b Published: 01 December 1979
Erratum: “Inter-Host Transmission of Carbapenemase-Producing <i>Escherichia coli</i> among Humans and Backyard Animals”
Authors: Jiyun Li, Zhenwang Bi, Shizhen Ma, Baoli Chen, Chang Cai, Junjia He, Stefan Schwarz, Chengtao Sun, Yuqing Zhou, Jia Yin, Anette Hulth, Yongqiang Wang, Zhangqi Shen, Shaolin Wang, Congming Wu, Lennart E. Nilsson, Timothy R. Walsh, Stefan Börjesson, Jianzhong Shen, Qiang Sun, Yang Wang
Journal: Environmental Health Perspectives (2020)
ETIOLOGY OF YELLOW FEVER.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NOT THE FIRST SESSION IN THE WEST.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quinine and Thrombotic Thrombocytopenic Purpura–Hemolytic Uremic Syndrome
Journal: Annals of Internal Medicine (2001)

Summaries for Patients18 December 2001Quinine and Thrombotic Thrombocytopenic Purpura–Hemolytic Uremic SyndromeSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-12-200112180-00004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Thrombotic thrombocytopenic purpura–hemolytic uremic syndrome (TTP–HUS) is an uncommon but serious illness that can cause death. In TTP–HUS, several organs (kidney, brain) get clogged with fragments of red blood cells and platelets. Red cells are broken down faster than they can be replaced (hemolytic anemia). Blood-clotting cells called platelets are reduced (thrombocytopenia) because they get stuck in the areas containing red blood cell fragments. Abnormal clotting or thrombosis results in many parts of the body. Symptoms include confusion, kidney failure, and increased bruising (purpura). Immediate treatment with exchange ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Quinine-Associated Thrombotic Thrombocytopenic Purpura–Hemolytic Uremic Syndrome: Frequency, Clinical Features, and Long-Term Outcomes.” It is in the 18 December 2001 issue of Annals of Internal Medicine (volume 135, pages 1047-1051). The authors are K Kojouri, SK Vesely, and JN George.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoQuinine-Associated Thrombotic Thrombocytopenic Purpura–Hemolytic Uremic Syndrome: Frequency, Clinical Features, and Long-Term Outcomes Kiarash Kojouri , Sara K. Vesely , and James N. George Metrics 18 December 2001Volume 135, Issue 12Page: I-65KeywordsBlood plasmaCellsDrugsKidneysMedical dialysisNutritionPlateletsQuinineRed blood cellsRenal failure ePublished: 18 December 2001 Issue Published: 18 December 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
FRI0341 Anti-Carp Antibodies in Two Large Cohorts of Patients with Rheumatoid Arthritis and their Relationship to Genetic Risk Factors, Cigarette Smoking and Other Autoantibodies
Authors: X. Jiang, L. Trouw, T. van Wesemael, J. Shi, C. Bengtsson, H. Kallberg, V. Malmstrom, L. Israelsson, H. Hreggvidsdottir, W. Verduyn, L. Klareskog, L. Alfredsson, T. Huizinga, R. Toes, K. Lundberg, D. Van Der Woude
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> In rheumatoid arthritis (RA), several genetic risk factors and smoking are strongly associated with the presence of anti-citrullinated protein antibodies (ACPA), while much less is known about risk factors for ACPA-negative RA. Antibodies against carbamylated proteins (anti-CarP) have been described in both ACPA-positive and ACPA-negative RA patients. <h3>Objectives</h3> In this study we have analysed the relationships between anti-CarP antibodies, ACPA, genetic risk factors (<i>HLA-DRB1</i> alleles and <i>PTPN22</i>) and smoking in RA. <h3>Methods</h3> Presence of antibodies to carbamylated fetal calf serum (CarP-FCS) and fibrinogen (CarP-Fib) was determined by in-house ELISAs in the Leiden Early Arthritis Cohort (EAC) and in the Swedish Epidemiological Investigation of RA (EIRA) cohort. Odds ratios for associations with different <i>HLA-DRB1</i> alleles, <i>PTPN22</i> genotypes and smoking were calculated separately for each cohort as well as in the combined meta-analysis, in RA subsets defined by anti-CarP and anti-cyclic citrullinated peptide (CCP) antibody status. <h3>Results</h3> In both cohorts, anti-CarP antibodies were mainly detected in the anti-CCP-positive population, but also in the anti-CCP-negative population. No associations between anti-CarP antibodies and <i>HLA-DRB1</i> shared epitope alleles could be identified, while a consistent signal for an association between anti-CarP-FCS and <i>HLA-DRB1*</i>03 was observed. Further analyses did not reveal any specific associations of anti-CarP antibodies with other <i>HLA-DRB1</i> alleles, <i>PTPN22</i> genotypes or smoking. <h3>Conclusions</h3> Anti-CarP antibodies were present in both ACPA-positive and ACPA-negative RA. Except for a modest association with <i>HLA-DRB1*</i>03, there were no strong associations between anti-CarP antibodies and <i>HLA-DRB1</i> alleles, <i>PTPN22</i> or smoking. These data suggest that different biological mechanisms may underlie anti-CarP versus anti-CCP antibody formation. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4653
Prospective multicenter trial for the response-adapted treatment of high-grade malignant non-Hodgkin’s lymphomas: Updated results of the COP-BLAM/IMVP-16 protocol with randomized adjuvant radiotherapy
Authors: Marianne Engelhard, P. Meusers, G. Brittinger, N. Brack, W. Dornoff, W. Enne, W. Gassmann, H. Gerhartz, M. Hallek, J. Heise, W. Hettchen, D. Huhn, K. Kabelitz, R. Kuse, E. Lengfelder, F. Ludwig, I. Meuthen, H. Radtke, C. Schadeck, C. Schöber, E. Schumacher, W. Siegert, H.-J. Staiger, E. Terhardt, E. Thiel, M. Thomas, T. Wagner, M. G. Willems, W. Wilmanns, T. Zwingers, H. Stein, M. Tiemann, K. Lennert
Journal: Annals of Oncology (1991)
Hodgkin Transformation Of Chronic Lymphocytic Leukemia (CLL): Mayo Clinic Experience
Authors: Sameer A. Parikh, Kari G. Rabe, Wei Ding, Timothy G. Call, Clive S. Zent, Susan Schwager, Neil E. Kay, Jose F. Leis, Susan L Slager, Tait D Shanafelt
Journal: Blood (2013)