tbuckley/cabot-search huggingface dataset:
Nutritional Medicine
Authors: Peter J. Dorsen
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Office Treatment of Rectal Diseases Explained and Simplified. Being an Exposition of the Treatment of all Those Diseases, Both Medical and Surgical, of the Rectum, Anus and Sigmoid Flexure, the Cure of which May Be Accomplished Without Surgical Anesthesia. Illustrated.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ochronotic densification.
Authors: E G Bywaters, J Dorling, J Sutor
Journal: Annals of the Rheumatic Diseases (1970)

Heberden Society 563 large scale; his book details various groups of occupa- tions running into several thousands of people, and his 9 1 mean is, I believe, fair.Of course, there is variation between different occupational groups.The next question is very important: these tests are not as precise as a haemoglobin estimation.If a patient's haemoglobin is 10 g. per cent.you have an accurate estimation, but a score of 12 on the Cornell Index is not in the same category; one should use these tests on groups rather than individuals.The last question
THE FORTHCOMING UNITED STATES PHARMACOPEIA
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasound
Authors: Michael B. Isikoff
Journal: JAMA (1977)

Evaluation of the jaundiced patient's condition frequently can be difficult. Clinical history, physical examination, liver function tests, and other laboratory data are often inconclusive in differentiating extrahepatic obstruction (surgical jaundice) from intrahepatic cholestasis (medical jaundice). During a 14-month period, we have evaluated 40 cases of jaundice of unknown causes. Ultrasound was able to correctly diagnose pathologically proved extrahepatic obstruction in 23 of 24 patients and intrahepatic cholestasis in 15 of 16 patients. There was one false-positive and one false-negative result in this series. (<i>JAMA</i>238:221-223, 1977)
OC-010 Detailed analysis of ATG16L1 demonstrates gene-wide extent of association with crohn's disease susceptibility
Authors: J Van Limbergen, B Kabakchiev, J Stempak, P Schumm, W Xu, P Henderson, A Griffiths, S Girardin, D Philpott, M Silverberg
Journal: Gut (2012)

<h3>Introduction</h3> ATG16L1 has been implicated in the susceptibility to Crohn9s disease (CD), notably the T300A (rs2241880, exon 9). In ATG16L1-deficient and hypomorphic mice, autophagy, Paneth-cell homeostasis and IL-1b secretion were dependent on ATG16L1 (Saitoh <i>et al</i> Nature 2008, Cadwell <i>et al</i> Cell 2010). In contrast, studies focusing on T300A have shown conflicting results (Kuballa <i>et al</i> PLoS ONE 2008, Fujita <i>et al</i> JBC 2009). The association at other susceptibility loci (eg, NOD2 and IL23R) consists of common and rare variants (Rivas <i>et al</i> Nat Genet 2011). Exon-sequencing studies have not demonstrated rare variants within the 18 exons of ATG16L1. Our aim was to analyse the ATG16L1 association signal, specifically focusing on common variants. <h3>Methods</h3> 38 single nucleotide polymorphisms (SNPs) spanning the ATG16L1 gene were imputed for 1735 subjects (800 CD/935 controls) (Franke <i>et al</i> Nat Genet 2010). Single SNP and haplotype frequency (&gt;1%, solid spine of Linkage disequilibrium (LD), D’&gt;0.8) association and permutation (n=10 000) analyses were performed (Haploview). Logistic regression (using SNPs p&lt;0.05 on permutation analysis) was performed (SPSS). Monte Carlo simulation (n=10 000, R) was used to assess the difference in the number of haplotype blocks, based on D9&gt;0.8, between CD and controls. <h3>Results</h3> Single SNP permutation analysis yielded association of 16 markers (p&lt;0.001), from intron 1 (rs6752107) to the 39UTR (rs1045100). Analysis of D9 and r<sup>2</sup> characteristics, showed 12 SNPs were in complete LD with rs2241880 (D9 and r<sup>2</sup> 0.98−1). rs6758317 (r<sup>2</sup>=0.25, intron 2), rs3792106 (r<sup>2</sup>=0.76, intron 11), rs4663396 (r<sup>2</sup>=0.25, intron 12) and rs1045100 (r<sup>2</sup>=0.84) demonstrated strong association, independent of rs2241880. Regression analysis retained rs3792106, rs6754677 (intron 14) and rs1045100 (39UTR) (p&lt;0.05). A Monte Carlo simulation showed no significant difference in the number of haplotype blocks between CD and controls (p=1). A strong association with CD was shown for the haplotype block containing the rs2241880 and for the block containing rs1045100, both p&lt;10<sup>−5</sup>. <h3>Conclusion</h3> We demonstrated that the rs2241880 alone is not sufficient to explain the strong ATG16L1 association. Additional variants, independent of rs2241880, could implicate any of the coiled-coil domain, the WD domain and/or the 39 UTR, in CD susceptibility. <h3>Competing interests</h3> None declared.
An In-Frame Deletion in Kir6.2 (KCNJ11) Causing Neonatal Diabetes Reveals a Site of Interaction between Kir6.2 and SUR1
Authors: Tim J. Craig, Kenju Shimomura, Reinhard W. Holl, Sarah E. Flanagan, Sian Ellard, Frances M. Ashcroft
Journal: Endocrine Reviews (2009)

Activating mutations in genes encoding the Kir6.2 (KCNJ11) and SUR1 (ABCC8) subunits of the pancreatic ATP-sensitive K+ channel are a common cause of permanent neonatal diabetes (PNDM). All Kir6.2 mutations identified to date are missense mutations. We describe here a novel in-frame deletion (residues 28–32) in Kir6.2 in a heterozygous patient with PNDM without neurological problems that are detected by standard evaluation. The aim of the study was to identify the mutation responsible for neonatal diabetes in this patient and characterize its functional effects. Wild-type and mutant Kir6.2/SUR1 channels were examined by heterologous expression in Xenopus oocytes. The Kir6.2–28Δ32 mutation produced a significant decrease in ATP inhibition and an increase in whole-cell KATP currents, explaining the diabetes of the patient. Tolbutamide block was only slightly reduced in the simulated heterozygous state, suggesting that the patient should respond to sulfonylurea therapy. The mutation decreased ATP inhibition indirectly, by increasing the intrinsic (unliganded) channel open probability. Neither effect was observed when Kir6.2 was expressed in the absence of SUR1, suggesting that the mutation impairs coupling between SUR1 and Kir6.2. Coimmunoprecipitation studies further revealed that the mutation disrupted a physical interaction between Kir6.2 and residues 1–288 (but not residues 1–196) of SUR1. We report a novel KCNJ11 mutation causing PNDM. Our results show that residues 28–32 in the N terminus of Kir6.2 interact both physically and functionally with SUR1 and suggest that residues 196–288 of SUR1 are important in this interaction.
Journal of Infectious Diseases, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Elements of Pharmacology.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dust from carpeted and smooth floors: IV. Solid material, proteins and allergens collected in the different filter stages of vacuum cleaners after ten days of use in schools.
Authors: T. Dybendal, W. C. Wedberg, S. Elsayed
Journal: Allergy (1991)

The accumulation of dust, proteins and allergens from alder, birch, timothy, cat, dog, mite, hen egg white, codfish and mould in schools was investigated by analysing the content of vacuum cleaners after 10 days of use. The main goals were to compare the dust accumulation on carpeted and smooth floors and to estimate to what degree the three vacuum cleaner filter stages (i.e. the disposable bag, the main filter and the microfilter) collected dust, proteins and allergens. Carpeted floors accumulated more dust, proteins and allergens per unit area than smooth floors. Histamine release studies of some of the dust extracts showed that the dust from carpeted floors released histamine from passively sensitized basophils at concentrations for which dust from smooth floors gave low or no histamine release. The analyses showed that most of the dust, proteins and allergens were retained in the dust bags. Less than 1 % of the vacuumed material had accumulated in the main filters, which, according to the manufacturer, detain 99.5% of particles &gt; 2 μm. By the use of a scanning electron microscope (SEM), particle deposits were observed in the microfilters. These deposits, which represented &lt; 0.1 % of the total mass, showed no significant allergenic activity. Thus, for the field conditions of this study, the microfilters were not needed for cleaning the exit air of allergens, although they were useful for removing fine (&lt; 2 μm) particles.
BOOK REVIEWS
Authors: F. M. FOSS
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article BOOK REVIEWS Get access Cutaneous Lymphoma: Current Problems in Dermatology, Volume 19 . W. A. van Vloten , R. Willemze , G. Lange Veglsgaard , K. Thomsen , eds. Basel : Karger , 1990 , 268 pp. $165.50. FRANCINE M. FOSS FRANCINE M. FOSS Navy Medical Oncology Branch Bethesda Naval Hospital Bldg. 8Rm. 5101 Bethesda, MD 20814 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 13, 4 July 1990, Page 1150, https://doi.org/10.1093/jnci/82.13.1150 Published: 04 July 1990
Multidrug-Resistant TB
Authors: Joan Stephenson
Journal: JAMA (2010)

Nearly one-third of the estimated 440 000 individuals worldwide infected with multidrug-resistant tuberculosis (MDR-TB) in 2008 died, said the World Health Organization (WHO) in a report released last month (http://whqlibdoc.who.int/publications/2010/9789241599191_eng.pdf).
Lead, health food, and leukemia
Authors: K. Schwarz
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Three items normally not connected with each other in our minds, namely, lead, health food, and leukemia, were treated jointly in the elegantly written article by William H. Crosby, MD, entitled "Lead-Contaminated Health Food: Association with Lead Poisoning and Leukemia" (237: 2627, 1977), and in an accompanying editorial (p 2636) that dramatized this multimessaged communication. Permit me to comment since the article described how I recognized by proxy a case of lead poisoning in a patient who contacted me in 1970. She described her story and her symptoms to me in a letter, and I diagnosed this case<i>tentatively</i>as one of lead poisoning, even though I am not a toxicologist, as alleged in the article. I have never seen the patient but have had lengthy telephone discussions with her and the treating physician. To my knowledge it has not been proved beyond any reasonable doubt that
Highlights
Journal: JAMA Pediatrics (2017)

Abusive head trauma accounts for most deaths because of physical abuse and most serious head injuries among infants.Dias and colleagues evaluated a statewide shaken baby prevention program in Pennsylvania among parents of all newborn infants.There was no diff erence in the rates of hospitalization for abusive head trauma over the intervention period in Pennsylvania compared with those of 5 other states.The accompanying editorial by Leventhal et al discussed the need to move beyond mother-focused, antishaking education during the postpartum period to prevent the potentially devastating injuries of abusive head trauma.
Dermatology
Authors: John G. Downing
Journal: New England Journal of Medicine (1949)

THE tremendous volume of papers on dermatology makes it impossible for the busy specialist to keep abreast of the literature. However, the establishment of the International Abstract, the Quarterly Review of Dermatology and Syphilology and the old favorite — the Year Book of Dermatology and Syphilology — lighten the burden. Many reports are repetitious; others are valueless. These reviews represent an attempt to separate the wheat from the chaff.An excellent presentation of the skin manifestations of systemic disease has been written by Wiener,1 who has coined the word "dermadrome" for such phenomena. The discovery of a systemic disease . . .
Pear-shaped ('teardrop') configuration of the urinary bladder. Excretory urography in a 63-year-old man
Authors: S. S. Shenoy
Journal: JAMA (1980)

<h3>History</h3> A 63-year-old man was admitted with an eight-month history of hypertension, anemia, and bilateral pedal edema. Physical examination revealed a firm mass in the right upper quadrant and bilateral pedal edema. The liver was slightly enlarged. Laboratory studies disclosed the following values: hemoglobin, 11.2 g/ dL; hematocrit, 33%; urinalysis, negative; lactic dehydrogenase, slightly elevated to 728 μmole/min; and alkaline phosphatase, slightly elevated to 105 μmole/min. An excretory urogram was obtained (Fig 1). <h3>Diagnosis</h3> Renal carcinoma with invasion and obstruction of the inferior vena cava. <h3>Comment</h3> An excretory urogram shows a mass in the middle and lower poles of the right kidney with distortion of the calices. The lower ureters are medially displaced, and the urinary bladder is pear-shaped with elevation of its base. Nephrotomography showed the renal mass to be solid. The evidence of a solid renal mass with a pear-shaped urinary bladder should suggest renal cell carcinoma invading
A critical appraisal of the quality of quality-of-life measurements
Authors: T. M. Gill
Journal: JAMA (1994)

<h3>Objective.</h3> —To evaluate how well quality of life is being measured in the medical literature and to offer a new approach to the measurement. <h3>Data Sources.</h3> —Original English-language articles having the term "quality of life" in their titles were identified from a recent Quality-of-Life Bibliography and from two MEDLINE searches. Articles were eligible for review only if they described or used one or more "quality-of-life" instruments. <h3>Study Selection.</h3> —Twenty-five articles were randomly selected from each of the three data sources. <h3>Data Extraction.</h3> —Each article was reviewed for its compliance with two sets of criteria having several components, which are cited under "Data Synthesis." <h3>Data Synthesis.</h3> —(1) Investigators conceptually defined quality of life in only 11 (15%) of the 75 articles; identified the targeted domains in only 35 (47%); gave reasons for selecting the chosen quality-of-life instruments in only 27 (36%); and aggregated their results into a composite quality-of-life score in only 27 (38%) of 71 eligible articles. (2) No article distinguished "overall" quality of life from health-related quality of life; patients were invited to give their own separate rating for quality of life in only 13 articles (17%); and among 71 eligible articles, patients were asked to supplement the stipulated items with personal responses in only nine (13%) and to rate the importance of individual items in only six (8.5%). <h3>Conclusions.</h3> —Because quality of life is a uniquely personal perception, denoting the way that individual patients feel about their health status and/or nonmedical aspects of their lives, most measurements of quality of life in the medical literature seem to aim at the wrong target. Quality of life can be suitably measured only by determining the opinions of patients and by supplementing (or replacing) the instruments developed by "experts." (<i>JAMA</i>. 1994;272:619-626)
Die Betrachtung und Betastung (Inspektion und Palpation) des Brustkorbs bei Lungenkranken. Klinische Untersuchungen über diagnostisch wichtige Erscheinungen am Knochengerüst, an Muskeln und Haut, sowie am Nerven- und Gefässsystem des Brustkorbs, mit besonderer Berücksichtigung halbseitiger Veränderungen.
Journal: JAMA (1930)
Masthead: (Adv. Healthcare Mater. 3/2017)
Journal: Advanced Healthcare Materials (2017)

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PLoS Medicine Issue Image | Vol. 4(11) November 2007
Journal: PLoS Medicine (2007)

This month's cover image, showing the treatment regimen of a patient coinfected with multi-drug resistant TB (MDR-TB) and HIV, links to a collection of three PLoS Medicine Policy Forum articles arising from the Médecins Sans Frontières Symposium "No Time to Wait: Overcoming the Gaps in TB Drug Development." For the first time in decades there is a TB drug pipeline, but the paucity of candidates is still cause for alarm (see Casenghi et al. e293). The long duration of current TB regimens, the high prevalence of HIV co-infection, and the emergence of drug-resistant TB underscore the need for new TB drugs, say Schluger et al. (e302) in their article on building TB clinical trials capacity in high-burden countries. The expansion of MDR-TB treatment programs provides the setting in which MDR-TB trials can be implemented, say Mitnick et al. (e292). Image Credit: Image by Brendan Bannon (http://www.brendanbannon.com/