tbuckley/cabot-search huggingface dataset:
In This Issue
Journal: Journal of Clinical Investigation (2009)

What happens when T cells just won't die?X-linked lymphoproliferative disease (XLP) is a rare inherited immunodeficiency most commonly caused by deficiency in SLAMassociated protein (SAP).Following primary infection with EBV, boys with XLP often develop an extreme, usually fatal accumulation of activated cytotoxic T lymphocytes, but the mechanistic link between this and SAP deficiency has not been determined.However, Snow and colleagues have found that T cells from individuals with XLP are resistant to apoptosis mediated by TCR restimulation, a process that normally constrains T cell expansion during immune responses, and propose that this makes the T cells susceptible to uncontrolled expansion upon infection (2976-2989).How SAP deficiency leads T cells to become resistant to apoptosis mediated by TCR restimulation was determined in a series of additional experiments.Specifically, SAP was shown to be required for TCR-induced upregulation of pro-apoptotic molecules, interacting with the SLAM family receptor NK, T, and B cell antigen (NTB-A) after TCR restimulation to augment the strength of the proximal TCR signal and achieve the threshold required for apoptosis.
THE ARMY MEDICAL DEPARTMENT OF MANILA.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selected New Books
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RENAL TRAUMA: TWO-HEADED MONSTER
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Test of Clearing by Means of Heparin in Atherosclerosis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colorectal neoplasia
Authors: M Bugnoli, D Armellini, R Rappuoli, Z-Y Xiang, A Rossolini, N Figura, J Crabtree
Journal: Gut (1992)

Helicobacter pylori (HP) is not a clonal pathogen.Only certain strains are able to produce a toxic -substance, a protein of ca.130 kDa, which induces intracytoplasmic vacuolization on cells in culture.The aim of this study was to further characterise this
Intestinal Surgery.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bronchioloalveolar carcinoma.
Authors: J E Barkley, M R Green
Journal: Journal of Clinical Oncology (1996)

PURPOSE To review bronchioloalveolar carcinoma (BAC). MATERIALS AND METHODS English language articles were identified through a Melvyl Medline Search (1966 to 1995) and through the bibliographies of selected articles. RESULTS An increase in BAC appears to be responsible for the observed rise in the incidence of adenocarcinoma of the lung. Patients with BAC tend to be younger at diagnosis, are more likely to be female, and less likely to be cigarette smokers when compared with other patients with non-small-cell lung cancer (NSCLC). The etiology of this disease is unclear, but multiple environmental insults have been implicated. There are three subtypes of BAC and the symptoms and prognosis of the disease depend on the subtype and extent of disease, but are generally similar to other histologic types of NSCLC. The radiographic differential diagnosis is broad and includes both benign and malignant diseases. The treatment approach to patients with BAC is similar to those with other types of NSCLC. CONCLUSION BAC appears to be increasing in incidence, especially in young, nonsmoking females. Three subtypes of the disease exist and are responsible for the variable clinical presentations. Further epidemiologic investigation is needed to elucidate the etiology and pathogenesis of this unique disease.
Infiltrating Lipomas of the Thigh
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sleepy Teens Take More Risks
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modified-fat dietary management of the young male with coronary disease. A five-year report
Authors: M. L. Bierenbaum
Journal: JAMA (1967)

One hundred young male outpatients with coronary disease who were under dietary management with a 28% fat diet were group-matched to a non-dietary-managed group in regard to age, age at infarction, number of infarctions, prevalence of hypertension, degree of angina, and value of serum cholesterol, among other factors. The diet-managed group experienced a significant reduction in serum cholesterol value, while the non-dietary-managed group did not. No significant differences were noted between the two groups in levels for serum total lipids, phospholipids, and triglycerides. Under the experimental conditions employed, the degree of unsaturation of the diet did not appear to influence serum cholesterol value or mortality. The non-dietary-managed group had a 160% higher recurrent infarction rate and a 233% higher mortality rate than did the dietary-managed group during the first five years of observation.
Comment: the other urinary tract cancer. Cancer of the ureter
Authors: P. Rubin
Journal: JAMA (1969)

Cancer of the ureter is rarely thought of when a patient is seen with one or a combination of the following: hematuria, back pain, or palpable abdominal mass. Most often, he is a man in the sixth decade of life, complaining of painless hematuria, although pain due to passage of clots can occur. Obstruction with hydronephrosis is an invariable complication, and produces a dull, aching back pain in the region of the kidney, but as the cancer infiltrates beyond the ureter, the pain becomes more localized and intense. Nodal metastases may result in spread beyond the capsule of the lymph gland into the lumbar vertebrae and nerve roots, causing severe, persistent, lacerating pain. The diagnosis of primary ureteral cancer is made preoperatively in only 50% of the patients,<sup>23</sup>since the ureter is more commonly involved secondarily by extrinsic neoplasms. The pyelogram is not characteristic and shows obstruction of the
Sepsis
Authors: Inge Van Herreweghe, Avram Benatar, Dirk Danschutter, José Ramet, F. Kirby, P. Whyte, D. Mannion, K. Butler, W. F. Casey, K. Tóth-Urbán, Zs. Wintsche, F. Leclerc, R. Cremer, C. Fourier, A. Martinot, S. Leteurtre, V. Hue, B. Jude, Borbála Mikos, Éva Biró, L. A. Glaría, D. Tamayo, M. Torres, F. Domínguez, M. Santurium, I. González, O. Martínez, J. Padrón, A. Rojas, I. A. von Rosenstiel, W. B. Vreede, Malcolm A. Lewis, D. V. Grinenko, E. P. Grinenko, T. O. Ivaschenko, I. P. Zhurilo, Z. Brajkovic, D. Maksimovic, N. Vunjak, V. Milikic, I. Jovanovic, P. Ivanovski, D. Kruscic
Journal: Intensive Care Medicine (1996)
Autism Clues?
Authors: Tracy Hampton
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Boxing
Authors: Maurice W. Van Allen
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Dr Morris believes that boxing should be neither prohibited nor<i>regulated</i>. Actually, it is already regulated in several states, although not well. Does he condone the matching of boxers with widely disparate talents when one will surely be hurt? Should a boxer rendered unconscious in a fight be allowed to fight again in a week.? Dr Morris fiercely defends one of this country's principles—that freedom of choice and action when it does no harm to others is an inalienable right. Who in the United States wishes to challenge this as a simple statement? None of us are really "autonomous." We are creatures of our heredity, culture, and immediate environment. Do disadvantaged children exposed to, recruited into, and trained for boxing have unlimited choices? Does Dr Morris know many professional boxers who are physician's children or who come from middleclass families? Would he encourage the free choice of a severely retarded
Severe Intestinal Reaction Following Ingestion of Rice
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tobacco foes attack ads that target women, minorities, teens, and the poor
Authors: P. Cotton
Journal: JAMA (1990)

FROM GHETTOS to ski slopes, tobacco advertisements are coming down. Advocates for minors, minorities, women, and the poor are on the offensive, scoffing at tobacco company claims that cigarette promotions are not aimed at the groups most at risk for acquiring nicotine addiction. Antismoking activists are adopting what they see as the industry's own tactics, moving away from wide-angle warnings about the long-term health threats and focusing instead on specific brands, the smoker's self-image, and the short-term social consequences, in messages tailored to specific groups. "We've done a good job of reaching middle-class white America, but not the groups most at risk," says American Cancer Society (ACS) spokesman Steve Dickinson. So new ACS ads twist the tobacco industry's images of success and sophistication. As a beautiful, dark-skinned woman smoking a cigarette becomes covered with a gloppy substance, the ad asks, "If what happened on your insides happened on your outsides,
Hepatitis D coinfection is associated with enhanced CXCR3 receptor expression of CD4 memory T cells and intrahepatic CXCR3 ligand expression compared to chronic hepatitis B patients
Authors: Jan-Hendrik Bockmann, Matin Kohsar, Katja Giersch, Lena Allweiss, Janine Kah, Tassilo Volz, Christin Ackermann, Andrea Pirosu, Marc Lutgehetmann, Ansgar W. Lohse, Julian Schulze zur Wiesch, Maura Dandri
Journal: Journal of Hepatology (2020)
Ledger of Monthly Balances and Index of Accounts, to Be Used in Connection with the Physicians' Protective Visiting List Constituting the Physicians' Protective Accountant.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Flucytosine treatment of Candida arthritis
Authors: S. A. Imbeau
Journal: JAMA (1977)

THE INCIDENCE of systemic candidiasis in hospitalized patients has risen markedly in the past decade,<sup>1</sup>but its occurrence is almost solely confined to persons with serious underlying disease or therapy that compromises host defense mechanisms. Septic arthritis is occasionally seen with systemic candidiasis, but isolated arthritis (without evidence of other<i>Candida</i>infection) is rare. We herein report the third documented case of isolated<i>Candida</i>arthritis; treatment with a short course of amphotericin B and then prolonged oral flucytosine was successful. <h3>Report of a Case</h3> A 75-year-old woman was referred to University Hospitals for treatment of suppurative arthritis. She had been receiving intra-articular steroid injections (beta-methasone, 0.25 ml, and triamcinolone hexacetonine, 1.25 ml) for degenerative arthritis of the knees since 1965. In 1973, a painful effusion developed in the left knee and<i>Candida parapsilosis</i>was isolated.
Report From NCHCT
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal