tbuckley/cabot-search huggingface dataset:
Dermatologica, Basel
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Older women do come for breast cancer screening
Journal: BMJ (1998)

Changed criteria for diabetes need further researchIn 1997 the American Diabetes Association changed the diagnostic fasting plasma value for glucose from 7.8 to 7.0 mmol/l.For screening and epidemiological studies they no longer recommended the standard 75 g oral glucose tolerance test recommended by the WHO.The DECODE Study Group's reanalysis of epidemiological studies in eight European countries-more than 26 000 patients-found that the two diagnostic criteria agreed in only 431 of 1517 people classified as diabetic (p 371).Because of this reclassification the group says that the WHO should wait for results of further reanalyses, with focus on prognostic impact, before it considers adopting the ADA criteria.
War wounded
Authors: Colin Martin
Journal: The Lancet (2008)

"Hardest of all was the task of trying to rekindle the desire to live in men condemned to live week after week smothered in bandages…all the while knowing themselves to be appallingly disfigured" wrote nurse Catherine Black, of the plight of more than 5000 battle-scarred British and Commonwealth soldiers, sailors, and airmen treated at Queen's Hospital, Sidcup, UK, between 1917 and 1925.
Nocturnal leg muscle cramps
Authors: I. H. Weiner
Journal: JAMA (1980)

NOCTURNAL leg muscle cramping (NLMC) is a frequent complaint heard by physicians in all specialties, from patients of all age groups, though probably most commonly in the elderly. Such muscle cramping usually involves the calf muscles (gastrocnemius or soleus) or the small intrinsic muscles of the sole of the foot. Both muscle groups are functionally similar, and the following discussion is applicable to both. Leg cramps usually occur at night in bed and are precipitated by random muscle contraction or, more frequently, by voluntary stretching movements of the lower extremities. They are exquisitely painful and a cause for much distress and anxiety. Nocturnal leg muscle cramping is to be sharply differentiated from leg cramps that occur from exercise such as walking or running. These can indicate an underlying pathologic process, such as the claudication of peripheral vascular insufficiency or the "pseudoclaudication" of radiculopathy, especially secondary to lumbar spinal stenosis. In
Industrial Noise
Authors: Edward C. Riley
Journal: New England Journal of Medicine (1963)

OCCUPATIONAL deafness has long been associated with certain noisy trades. With the advent of the steam engine came the job of boilermaker, one of the noisiest. The expression, "boilermaker's disease," is sometimes used as a synonym for occupational deafness. Many other jobs involving the use of steam, electric, compressed-air and internal-combustion power to shape metal and operate machines create noise intensities capable of damaging hearing after prolonged exposure. Since the loss of hearing develops slowly, the occupational relation is not always recognized. For many years, neither physicians nor workers were greatly disturbed, and boilermaker's deafness was viewed as a hazard . . .
Enfermedades del Estomago.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short-Term and Long-Term Physical Effects of Exposure to CS Spray
Authors: Y G Karagama, J R Newton, C J R Newbegin
Journal: Journal of the Royal Society of Medicine (2003)

CS gas (2-chlorobenzylidene malonitrile) is widely used in an incapacitant spray that causes intense lacrimation, blepharospasm and burning sensations in the throat and nose. Questions have been raised about its safety. We obtained information on short-term and long-term symptoms, and performed ear, nose and throat examinations and respirometry at 8–10 months, in 34 young adults who had been exposed to CS spray in a confined space during a confrontation with police. The group was subdivided into those who had been sprayed directly on the face ( n=10) and those exposed indirectly. At one hour, all but 2 individuals still had symptoms; respiratory and oral symptoms were significantly more prevalent in the directly exposed group. At one month, only oral symptoms were significantly more prevalent. At 8–10 months, symptoms were still reported but there were no differences between the groups and clinical examinations revealed no specific abnormalities. There was no convincing evidence of long-term physical sequelae from exposure to CS spray.
P01.021 Comprehensive Geriatric Assessment (CGA) for outcome prediction in elderly patients (PTS)with glioblastoma (GBM): a mono-institutional experience
Authors: G Lombardi, E Bergo, L Bellu, M Caccese, A Lettiero, G Tierno, A Pambuku, A Brunello, V Zagonel
Journal: Neuro-Oncology (2018)

Treatment for GBM elderly PTS is still a challenge in neuro-oncology. Clinical tools, including CGA, are needed for improving treatment decision and outcome. To date, few studies exploring the impact of CGA on outcome have been performed in these PTS. The aim of this study was to evaluate CGA as a prognostic tool in terms of PFS and OS in elderly GBM PTS. we performed a retrospective analysis of elderly PTS ≥ 65 years, treated at Veneto Institute of Oncology between January 2011 and January 2018, with newly histologically diagnosed GBM and receiving a baseline CGA after 3–4 weeks from surgery. CGA included the following domains: age, activities and instrumental activities of daily living (ADL, IADL), cognitive status(MMSE), mood (GDS), nutritional status (MNA), number of drugs, comorbidity (cumulative Illness Rating Scale-CIRS), presence of geriatric syndromes, presence of caregiver. PTS were classifiedaccording to Balducci’s criteria into Fit or Unfit (Frail and Vulnerable). 113 PTS were enrolled: 72 (64%) were male, KPS were ≥ 70 in 90 PTS (80%); 37 PTS (33%) had a radical surgery, 63% partial surgery and 4% received a biopsy. 90 PTS (80%) received Stupp treatment, 16 (14%) temozolomide or radiotherapy alone and, only 7 (6%) received no treatment. MGMT methylation status was analyzed in 96 PTS: 44% were metMGMT. According to CGA evaluation: 40 PTS (35.4%) were classified as Fit and 73 PTS (64.6%) Unfit. PFS was 11.2 (95% CI 6.0–16.4) and 7.2 (95% CI 5.8–8.6) months for Fit and Unfit PTS (p=0.1). On multivariate analysis, adjusted for type of surgery, MGMT methylation status and type of therapy, PFS wassignificantly different between the two groups (HR=0.6, 95% CI 0.2–0.9; p=0.04). OS was 16.4 (95% CI 14.6–18.2) and 10.6 (95% CI 8.3–12.8) ms for Fit and Unfit PTS (p=0.04); on multivariate analysis the HR was 0.51 (95% CI 0.2–0.9; p=0.04). CGA demonstrated significant outcome prediction in terms of OS and PFS, regardless of therapy. It could be a useful treatment decision-tool suggesting to treat FIT PTS with radiochemotherapy while a prospective study to evaluate the best treatment in Unfit PTS should be warrant.
Insomnia
Authors: Matthew R Ebben, Mary C Kapella
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

What is insomnia?Insomnia is a condition that describes difficulty with sleep.This condition can include difficulty falling asleep, problems staying asleep, frequently awakening at night (fragmented sleep), and/ or awakening early in the morning.This trouble sleeping results in feeling unrefreshed during the day and difficulty with daytime function including completing valued daily activities. Who develops insomnia?When and why insomnia begins, is not always known and therefore can be difficult to understand.We know that certain groups of people have a greater risk for developing insomnia.These include those with mood conditions (such as anxiety and/ or depression), women, older people and individuals with chronic medical conditions such as asthma and COPD (see ATS Patient Series http://patients.thoracic.org/wp-content/uploads/2014/03/ATS_Patient_Ed_ Sleep_Problems_d_MT-09112013-Final.pdf).Your mood can affect your sleep, but improving your sleep problem can also help symptoms of anxiety and depression.Sleep can also be affected by medications.For example, medications often taken by those with lung problems include beta agonists, prednisone and theophylline-containing medication.Any of these can cause symptoms of insomnia.The initial cause of your sleeping difficulty however, may not be the reason why you continue to have poor quality sleep.For example, often sleep difficulty begins as a result of a sudden event (death of a friend or family member, the break-up of a relationship, increased stress at work, or losing one's job etc.).However, in some cases, once the event has
Film Produced to Combat Ignorance of Genital Herpes Infection
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DOCTORS AND HEALTH.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Future of Obstetrics and Gynecology
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PREPARE FOR THE FOURTH OF JULY
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3441: A RPL39-SGK3 signaling pathway that may play a key role in breast cancer therapy resistance
Authors: Dan Liu, Bhuvanesh Dave
Journal: Cancer Research (2019)

Abstract Breast cancer is the most common cancer in the United States, where 1 in 8 women are affected by it during their lifetime. In 2018, an estimated 266,120 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 63,960 new cases of non-invasive (in situ) breast cancer. In order to identify novel targets and better understand the mechanism of survival of these cancers, we describe the mechanism of action of ribosomal protein like 39 (RPL39) as one potentially useful target for therapy resistance. RPL39 is over-expressed in breast cancer and regulated by nitric oxide signaling (NOS). In the present study we examine the detailed mechanism of action of RPL39 as it relates to treatment-resistant breast cancers and the role of SGK3 in modulating its signal transduction pathway. Methods and Results: Mass spectrometric analysis following immunoprecipitation of RPL39, in two breast cancer cell lines SUM159 and MDAMB231, indicated that proteins involved in translation, specifically the mTOR-dependent translational pathway, were part of the complex. In order to verify that the results we observed were due to targeting of the translational arm of mTOR signaling, we knocked down both the 4EBP-1 (translation) and S6K (cell size) arms of the mTOR pathway in three breast cancer cell lines (SUM159, MDAMB231 and MDAMB436). Analysis of these pathways by proliferation, apoptosis, sphere formation and western blotting in all three breast cancer cell lines demonstrated that the translation arm was significantly altered: self-renewal (p&amp;lt;0.05, Student's t test) and proliferation (p&amp;lt;0.05, student's t test) in a NOS signaling dependent manner. Additional bioinformatic analysis determined a potential role for SGK3 upstream of RPL39. SGK3 is an AGC kinase family member that is over-expressed in ER+ breast cancers. It functions downstream of PI 3-kinase and can activate the mTOR pathway. Conclusion: RPL39 gene may be modulated by the selective translational initiation complex which affects self-renewal and proliferation through SGK3 and NOS signaling. The significance of targeting SGK3 and RPL39 pathway allows a potentially novel therapeutic strategy for the treatment of breast cancer. Citation Format: Dan Liu, Bhuvanesh Dave. A RPL39-SGK3 signaling pathway that may play a key role in breast cancer therapy resistance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3441.
Commentary
Authors: Takao Itoi
Journal: Endoscopy (2020)

This novel technique demonstrates that endoscopic retrograde cholangiopancreatography (ERCP)-type procedures can be safely performed without fluoroscopy by using the duodenoscope in combination with transabdominal ultrasound. Nowadays, ERCP is the first-line therapy for decompression of the bile ducts in patients with suppurative cholangitis, a life-threatening condition. Apart from endoscopy for gastrointestinal tract diseases, ERCP requires fluoroscopy as well as the duodenoscope to obtain cholangiopancreatography. Thus, if the fluoroscopy system is unavailable, for example because of breakage, the condition of patients with acute cholangitis needing bile duct drainage, can deteriorate finally becoming lethal. To the best of its authors’ knowledge, this is the first video report of radiation-free direct endoscopic drainage of the common bile duct using transabdominal ultrasound. Mönkemüller et al. are to be congratulated on this distinctive report.
Arquivoso-Ps-Neuro-Psiquiatria, São Paulo
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEW
Authors: E. S. WIENER, J. MIRRO
Journal: JNCI Journal of the National Cancer Institute (1995)

BOOK REVIEW Vascular Access in the Cancer Patient: Devices, Insertion Techniques, Maintenance, and Prevention and Management of Complications H. Richard Alexander , ed . Philadelphia : J. B. Lippincott Company , 1994 . 179 pp., illus. ISBN 0-397-51316-X EUGENE S. WIENER, EUGENE S. WIENER Search for other works by this author on: Oxford Academic PubMed Google Scholar JOSEPH MIRRO, JR JOSEPH MIRRO, JR Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 8, 19 April 1995, Pages 604–605, https://doi.org/10.1093/jnci/87.8.604 Published: 19 April 1995
Hoarse voice
Authors: O. Judd, I. B. Colvin
Journal: BMJ (2010)

A 38 year old woman who is a teacher presents with a three week history of hoarse voice after a common cold. It is intermittent, with normal voice in between. She reports a sensation of having phlegm in the throat that constantly needs to be cleared. Hoarseness has a prevalence of 6% in the general population, rising to 11% for professional voice users (30% of the workforce). Most episodes are benign and resolve with vocal hygiene (see box). Laryngeal cancer is an important, but rare, cause of hoarseness (5/100 000 in males and 1/100 000 in females). Most patients with laryngeal cancer have risk factors, mainly smoking, high alcohol intake, and increasing age (72% of cancers occur over the age of 60). Heavy smoking and drinking are synergistic risk factors, and together increase risk 80-fold. #### Vocal hygiene advice for patients ##### Avoid
International Workshop on the Use of Rodent Tumors in Experimental Cancer Therapy
Journal: JNCI Journal of the National Cancer Institute (1984)

International Workshop on the Use of Rodent Tumors in Experimental Cancer Therapy Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 5, May 1984, Page 1210, https://doi.org/10.1093/jnci/72.5.1210 Published: 01 May 1984
Boston Medical Library
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1952)

A number of works of unusual merit in medicohistorical literature were published in 1951. Four, at least, were outstanding. The first and foremost was the publication of Sigerist's first volume of his monumental History of Medicine (New York: Oxford University Press), reviewed by the Librarian in Centaurus (1:388–391, 1951). The book covers the period of primitive and archaic medicine, including the beginnings in Egypt and Mesopotamia. Of value, too, are the appendixes on histories of medicine, source books and museums.Another contribution consisted of the two stout volumes of the Letters of Benjamin Rush (Princeton: University Press), skillfully edited by . . .