tbuckley/cabot-search huggingface dataset:
Abstract 2648: Self-renewing cellular compartments in embryonal rhabdomyosarcoma are modulated by Hedgehog signaling.
Authors: Sampoorna Satheesha, Nurhak Dogan, Elisa A. Casanova, Dagmar Walter, Beat W. Schäfer
Journal: Cancer Research (2013)

Abstract Rhabdomyosarcoma (RMS) is a heterogeneous group of malignancies with features of impaired skeletal muscle differentiation and represents the majority of the soft tissue cancers in the pediatric age group. Current treatment regimens offer some clinical respite but at a significant risk of averse side effects and secondary tumors later in life. Identifying and targeting sub-populations with higher tumorigenic potential and self renewal capacity not only decreases tumor burden but also lowers the probability of relapse. Using the sphere formation assay we could select for self-renewing cells from the heterogeneous monolayer cultures of embryonal RMS (eRMS) cell lines, RD and Rh36, which had multipotent differentiation ability in vitro and greater tumorigenic potential in vivo. These cells also showed increased expression of embryonic stem cell genes. Interestingly, quantitative gene expression analysis revealed increased expression of various components of the Hedgehog pathway, a developmental pathway important in eRMS biology. Inhibition or activation of the pathway in vitro by small molecule agents led to increased or decreased self renewing ability respectively. Furthermore we observed that eRMS adherent monolayer cultures contained a sub-population of GLI1-positive cells which could be modulated by pathway manipulation. Importantly, inhibition of the hedgehog pathway in vitro led to significantly delayed tumor initiation in vivo. Ongoing experiments aim at confirming these results on the genetic level. We postulate that the Hedgehog pathway sustains a primitive cellular compartment necessary for tumor initiation within embryonal RMS cell lines. Citation Format: Sampoorna Satheesha, Nurhak Dogan, Elisa A. Casanova, Dagmar Walter, Beat W. Schäfer. Self-renewing cellular compartments in embryonal rhabdomyosarcoma are modulated by Hedgehog signaling. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2648. doi:10.1158/1538-7445.AM2013-2648
Behavioral Risk Factors in Colorectal Cancer Linked to Socioeconomic Factors
Journal: JNCI Journal of the National Cancer Institute (2012)

Physical inactivity, unhealthy dietary habits, and other health disparities commonly found in low socioeconomic status (SES) populations may be associated with a higher risk of colorectal cancer incidence in the U.S., according to a study published September 4 in the Journal of the National Cancer Institute.Behavioral risk factors and obesity are more common in low-SES populations in the U.S. compared to more wealthy populations, and unhealthy lifestyles may account for up to 70% of colorectal cancers.While epidemiological and biological studies have shown that unhealthy lifestyles can lead to colorectal cancer, the reason these lifestyles effect low-SES populations to such a large degree remain unknown.In order to determine how behavioral risk factors and obesity affect low-SES populations, Chyke A. Doubeni, M.D., M.P.H., of the Department of Family Medicine and
TB Vaccine
Authors: Joan Stephenson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PHILADELPHIA SESSION
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV testing in Europe: from policies to effectiveness some highlights from the meeting
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2008)

It has been estimated that 30 percent of people living with HIV in the European Union (EU) are unaware of their infection [1]. As undiagnosed patients cannot benefit from early treatment and may unknowingly transmit HIV to others, this situation poses a major challenge in the fight against the HIV/AIDS epidemic.
Environmental tobacco smoke. The Brown and Williamson documents
Authors: D. E. Barnes
Journal: JAMA (1995)

<h3>Objective.</h3> —To examine the tobacco industry's public and private responses to rising concern over the health effects of environmental tobacco smoke (ETS). <h3>Data Sources.</h3> —Documents from Brown and Williamson Tobacco Corporation (B&amp;W), the British American Tobacco Company (BAT), and other tobacco interests provided by an anonymous source, obtained from Congress, and received from the private papers of a former BAT officer. <h3>Study Selection.</h3> —All available materials, including confidential reports regarding research and internal memoranda exchanged between tobacco industry lawyers. <h3>Conclusions.</h3> —Privately, B&amp;W and BAT began conducting research related to ETS in the mid 1970s. BAT researchers appear to have determined that sidestream smoke produces irritation, that it contains toxic substances including<i>N</i>-nitrosamines, and that it is "biologically active" (eg, carcinogenic) in laboratory tests. During the 1980s, the primary purpose of BAT's research related to ETS was to develop a new cigarette that emitted less irritating and less biologically active sidestream smoke. Publicly, the tobacco industry has denied that exposure to ETS has been proven dangerous to health. It has criticized the methodology of published research on ETS, even when some of its own consultants have privately acknowledged that the research was valid. In addition, the industry has funded scientific research with the stated purpose of anticipating and refuting the evidence against ETS. The tobacco industry's strategy regarding passive smoking has been remarkarbly similar to its strategy regarding active smoking. It has privately conducted internal research, at least some of which has supported the conclusion that passive smoking is dangerous to health, while it has publicly denied that the hazards have been proven. (<i>JAMA</i>. 1995;274:248-253)
Table of Diseases Treated Between the 24th of February, 1843, and the 31st of January, 1846
Authors: G. Fife
Journal: BMJ (1846)

Now, the first fact which strikes is, that the two augmentations in the admissions noted above, the one in January, the other in April, May, and June, (that of December belongs, under this point of view, to the year 1846,) are felt (retentiesent) upon the numbers of the discharged at intervals sufficiently well determined.Thus the number of admissions in January is very high ; the proportion of the dismissals, instead of augmenting in the following month, diminishes.It does not increase till the month of March, and still more the month of April.At this time there occurs a rapid increase of admissions; the old inralids are dismissed; beds are made up, to use the appropriate expression; and the number of the dismissals is increased.But then follows an interesting phenomenon, and having a different signification; from April to May, the amount of admissions augments, that of the dis- misals diminishes; from May to June the reverse occurs; the admissions diminish, whilst those going out increase in number.*Here, evidently, the neces- sities of the service have no part in the movement.In order then that the dismissals may become less frequent, as the admissions become more numerous, and vice versa, some other cause is requisite than the degree of frequency of the diseases, and this can only be their importance and their duration.If there are, proportionally fewer patients discharged in May than in April, whilst there are more admitted, it is evident that the individuals admitted during this last month must continue to increase the population of the hospitals, that is in a certain number the disease is prolonged.So also, if in June there are discharged proportionably more patients than in May, at the same time that there are fewer admitted, it is because a certain number of individuals still iri the hospital in this last month feel themselves in a state for leaving.
Uncooked Foods and How to Use Them. A Treatise on How to Get the Highest Form of Animal Energy from Food, with Recipes for Preparation, Healthful Combinations and Menus.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence and determinants of seborrheic dermatitis in a middle‐aged and elderly population: the Rotterdam Study
Authors: M.G.H. Sanders, L.M. Pardo, O.H. Franco, R.S. Ginger, T. Nijsten
Journal: British Journal of Dermatology (2018)

Seborrheic dermatitis is a common skin disorder occurring on the scalp, face and chest and is characterized by inflammation and a greasy scaling. It is not clear what causes seborrheic dermatitis, but it is thought that overgrowth of Malassezia yeasts contributes to developing seborrheic dermatitis. Several other factors have been associated with the disease as well; age, sex, obesity, skin colour, stress, depression, education level, hypertension, climate, xerosis cutis, alcohol and tobacco use have all been associated with seborrheic dermatitis, but the evidence for these associations was often not conclusive. The aim of this study was to establish which lifestyle and physiological factors are associated with seborrheic dermatitis. Data from the Rotterdam Study of middle aged and elderly people from the Netherlands, was used to investigate these previously reported factors. The rationale is that knowledge about determinants could provide new insights in the pathophysiology of seborrheic dermatitis, which might lead to preventative strategies and/or new treatment regimes. In the Rotterdam study, 5,498 participants underwent a full body skin examination, of which 788 had seborrheic dermatitis. The authors found that male sex, light skin colour, winter season and a generalised dry skin increased the likelihood of having seborrheic dermatitis and that the other factors were not associated with seborrheic dermatitis. Further, the authors conducted an analysis to investigate if the gender differences could be explained by hormonal differences, but they did not find an association between hormones and seborrheic dermatitis. Of the found associations, a dry skin seems the easiest to influence. Improving the skin barrier could therefore become a target in the treatment of seborrheic dermatitis.
IMMUNOLOGY RESEARCH
Authors: M. Barish, L. Weng, M. D'Apuzzo, S. Forman, C. Brown, I. Ben Horin, I. Volovitz, Z. Ram, A. Chang, D. Wainwright, M. Dey, Y. Han, M. Lesniak, K. Chow, J. Yi, D. Shaffer, S. Gottschalk, A. Clark, M. Safaee, T. Oh, M. Ivan, R. Kaur, M. Sun, Y.-J. Lu, T. Ozawa, C. D. James, O. Bloch, A. Parsa, W. Debinski, Y. A. Choi, D. M. Gibo, M. Dey, D. Wainwright, A. Chang, Y. Han, M. Lesniak, C. Herold-Mende, J. Mossemann, C. Jungk, R. Ahmadi, D. Capper, A. von Deimling, A. Unterberg, P. Beckhove, H. Jiang, S. R. Klein, S. Piya, L. Vence, W. K. A. Yung, R. Sawaya, A. Heimberger, C. Conrad, F. Lang, C. Gomez-Manzano, J. Fueyo, T.-Y. Jung, Y.-D. Choi, Y.-H. Kim, J.-J. Lee, H.-S. Kim, J.-S. Kim, S.-K. Kim, S. Jung, D. Cho, A. Kosaka, T. Ohkuri, H. Okada, K. Erickson, C. Malone, E. Ha, H. Soto, M. Hickey, G. Owens, L. Liau, R. Prins, B. Minev, C. Kruse, J. Lee, X. Dang, A. Borboa, R. Coimbra, A. Baird, B. Eliceiri, D. Mathios, M. Lim, J. Ruzevick, S. Nicholas, M. Polanczyk, C. Jackson, J. Taube, P. Burger, A. Martin, H. Xu, K. Ochs, F. Sahm, C. A. Opitz, T. V. Lanz, I. Oezen, P.-O. Couraud, A. von Deimling, W. Wick, M. Platten, T. Ohkuri, A. Ghosh, A. Kosaka, J. Zhu, M. Ikeura, S. Watkins, S. Sarkar, H. Okada, S. Pellegatta, S. Pessina, G. Cantini, D. Kapetis, G. Finocchiaro, T. Avril, E. Vauleon, A. Hamlat, J. Mosser, V. Quillien, B. Raychaudhuri, P. Rayman, P. Huang, M. Grabowski, D. Hamburdzumyan, J. Finke, M. Vogelbaum, D. Renner, A. Litterman, A. Balgeman, F. Jin, L. Hanson, J. Gamez, B. Carlson, J. Sarkaria, I. Parney, J. Ohlfest, I. Pirko, K. Pavelko, A. Johnson, J. Sims, B. Grinshpun, Y. Feng, B. Amendolara, Y. Shen, P. Canoll, P. Sims, J. Bruce, S. X. Lee, E. Wong, K. Swanson, D. Wainwright, A. Chang, M. Dey, I. Balyasnikova, Y. Cheng, Y. Han, M. Lesniak, F. Wang, J. Wei, S. Xu, X. Ling, N. Yaghi, L.-Y. Kong, T. Doucette, J. Weinberg, F. DeMonte, F. Lang, S. Prabhu, A. Heimberger, J. Wiencke, W. Accomando, E. A. Houseman, H. Nelson, M. Wrensch, J. Wiemels, S. Zheng, G. Hsuang, P. Bracci, K. Kelsey
Journal: Neuro-Oncology (2013)
Treatment IND for Non—Insulin-Dependent Diabetes Mellitus
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New quinolone generation active over wide spectrum
Authors: D. E. Riesenberg
Journal: JAMA (1986)

They are related to nalidixic acid, have a very broad spectrum of activity, and may be useful in a wide range of deep-seated infections—orally. They are known as the second generation quinolones. However, this exciting group of at least 12 new compounds is not yet clinically available. Scientists attending the Interscience Conference on Antimicrobial Agents and Chemotherapy in Minneapolis had the opportunity to hear nearly 100 presentations concerning the newer quinolones. The parent compound, nalidixic acid, is effective in treating urinary tract infections, but controversy has existed for years over whether resistant organisms emerge rapidly during therapy (<i>JAMA</i>1976;236:1857-1860). According to Jerome Boscia, MD, associate professor of medicine, Medical College of Pennsylvania, Philadelphia, it also has been difficult to achieve adequate blood levels of nalidixic acid and other older quinolones. "They were great for urinary tract infections, but they really didn't give good serum levels," says Boscia. Initial reports, from in
Respiratory Physiology
Authors: W. M. Foster
Journal: JAMA (1982)

<b>Pathophysiology of Respiration</b>, edited by Meir H. Kryger (<i>Wiley Pathophysiology Series</i>, Neville Bittar, ed), 352 pp, with illus, paper, $17.50, New York, John Wiley &amp; Sons Inc, 1981. <i>Respiratory Physiology</i>by N. B. Slonim and L. H. Hamilton is the fourth edition of this text, which, as described by the authors, has the objective of presenting explicitly and tersely the physiology of human respiration and is structured primarily for use by medical students. By comparison with others, this book is rather abbreviated, comprising only 239 pages of actual text, 11 tables, and 78 figures, with an additional 62 pages of appendix, glossary, and index. Despite claims by the authors that this new edition has been expanded and extended in the direction of the new organ system biology, there is hardly a discernible expansion of the text, and new chapters have not been added. The authors have subdivided existing chapters from
Ocular findings in patients with histoplasmosis
Authors: S. S. Feman
Journal: JAMA (1985)

Presumed ocular histoplasmosis syndrome is a multifocal choroiditis; it is not an uncommon cause of visual loss in patients who have positive cutaneous responses to histoplasmin tests. However,<i>Histoplasma capsulatum</i>infection is, most often, a pulmonary disease, or a systemically disseminated disorder, without visual symptoms. For this reason, a correspondence between the nonocular and ocular aspects of this disorder has been difficult to ascertain. In a series of eight patients with histoplasmosis, we found asymptomatic ocular lesions in six. We believe that the presence of asymptomatic lesions may have prevented earlier investigators from recognizing this correlation. (<i>JAMA</i>1985;253:2534-2537)
<i>Announcement: </i>World No Tobacco Day — May 31, 2017
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

May is National Arthritis Awareness Month.In the United States, approximately 54 million (1) adults have some form of doctor-diagnosed arthritis; this number is projected to increase to 78 million by 2040 (2).In addition, arthritis-attributable activity limitation currently affects an estimated 24 million adults with arthritis (1), and this is expected to rise to 35 million by 2040 (2).Approximately one in three adults with arthritis have severe joint pain (1).Arthritis is a leading cause of disability and makes it harder to manage other co-occurring conditions, such as diabetes, heart disease, and obesity.A Vital Signs report on arthritis prevalence (1) was published in MMWR in March 2017 to increase awareness of arthritis, its impact in the United States, and what can be done by health care providers, adults with arthritis, and state and community leaders to address these issues.CDC recommends physical activity and a variety of evidence-based physical activity and self-management education programs.Physical activity can reduce arthritis pain and improve function by about 40%, and self-management education workshops, such as the Chronic Disease Self-Management Program, have shown 10%-20% improvements in pain, fatigue, and depression in adults with arthritis (3).CDC funds 12 state health departments and several national organizations to disseminate these programs in local communities.
Demonstration of Possible Auto
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal