tbuckley/cabot-search huggingface dataset:
Enzymorphology of Adenocarcinoma of the Endometrium: β-Glucuronidase, Acid Phosphatase, DPNH-Diaphorase, and α-Naphthyl Esterase
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SFGM-TC MDS SCORE AT DAY 180 IS ASSOCIATED WITH POST-TRANSPLANT OUTCOMES IN PATIENTS WITH MYELODYSPLASTIC SYNDROME WHO UNDERWENT CD34+ SELECTED ALLOGENEIC STEM CELL TRANSPLANT
Authors: A. Alarcon, S. Devlin, M. Maloy, J. D. Ruiz, Sanchez M. Escamilla, R. Tamari, B. Shaffer, H. Castro-Malaspina, S. Giralt, M. A. Perales
Journal: HemaSphere (2019)
Abstract 1621: Multiplex analysis of proteins for cancer diagnosis: A case study using ActivSignal technology
Authors: Ilya Alexandrov, Malcolm Mackenzie, Irina Brandina
Journal: Cancer Research (2019)

Abstract Pancreatic cancer is one of the deadliest types of cancer, killing over 50,000 each year in the US, and with a five-year survival rate below 8%. However, currently there are no reliable diagnostic tests for pancreatic cancer, and the great majority of cases are detected at a late stage, with bleak mortality rates as a result. The ActivSignal IPAD platform monitors activity of 26 cancer signaling pathways in multiplex, by examining phosphorylation status or expression of 70 protein targets. The technology utilizes pairs of antibodies per each protein target to ensure high specificity. These antibody pairs are carefully tested and selected. Detection will only take place if both antibodies in a pair bind to their specific target molecule during the analysis phase - avoiding false hits. The ActivSignal IPAD platform can be used to profile cell culture samples, tissues and different blood fractions. The IPAD assay requires a very small amount of sample. All these characteristics make it potentially adaptable for diagnostics, simultaneously profiling multiple proteins targets. We have tested the assay in a preliminary analysis of human pancreatic cancer patients. Several control and pancreatic ductal adenocarcinoma (PDAC) blood samples were used for analysis. The assay can be performed on a very small volume of material, and 100 microliters of each sample was obtained from a collaborating academic medical center. The profiling was performed on 40 previously identified, relevant proteins. The comparison of Normal controls and PDAC patient samples gave a clear pattern that discriminated these two population groups with a great degree of certainty. Thus, giving a proof of concept that the assay can be used for diagnostic development for pancreatic cancer detection, an urgent unmet need. Citation Format: Ilya Alexandrov, Malcolm Mackenzie, Irina Brandina. Multiplex analysis of proteins for cancer diagnosis: A case study using ActivSignal technology [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1621.
How Psychiatry Helps
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical education and financial assistance programs sponsored by US government agencies
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary
Authors: Philip Wai Yan Chiu
Journal: Endoscopy (2020)

In this E-Video, Hallit et al. demonstrate the performance of peroral endoscopic myotomy (POEM), using an underwater technique, for the treatment of achalasia. As the majority of cohort studies show that the commonest adverse events observed following POEM are related to insufflation causing pneumothorax, pneumomediastinum, and pneumoperitoneum, the use of an underwater technique has the potential to mitigate these effects.
ECG Challenge: April 1, 2014
Authors: Philip Podrid
Journal: Circulation (2014)

ECG Challenge 1452A 65-year-old woman with a history of hypertension for which she is taking a β-blocker and an angiotensin-converting enzyme inhibitor is admitted to the hospital because of a cerebrovascular accident.While on telemetry, she is noted to have significant bradycardia, and an ECG is obtained.What is the diagnosis?To submit your diagnosis, go to http://circ.ahajournals.
Acute renal failure following arteriography in a patient with polyarteritis nodosa
Authors: J. S. Kaur
Journal: JAMA (1982)

The use of radioiodinated contrast material has become an important diagnostic aid. However, certain categories of patients appear to be at risk for development of oliguric acute renal failure after receiving radiocontrast media. In this article, a patient with polyarteritis nodosa is presented who had development of oliguric azotemia after angiography; the loss in renal function was largely irreversible. The course of this patient suggests that active vasculitis, even in the presence of an inactive urine sediment, may be an additional risk factor for development of acute renal failure when considering the use of radioiodinated contrast material. (<i>JAMA</i>1982;247:833-834)
High frequency of mitral valve prolapse and aortic regurgitation among asymptomatic adults with Down's syndrome
Authors: S. Z. Goldhaber
Journal: JAMA (1987)

Although cardiac anomalies are well documented among children with Down's syndrome, data on the cardiac status of adults with Down's syndrome are sparse. Therefore, we performed cardiac auscultation and Doppler echocardiographic examinations in 35 asymptomatic adults with Down's syndrome. There were 25 men and ten women; their mean age ( ± SD) was 26 ± 8 years. Only ten subjects (29%) had normal findings on examination. The most frequent abnormal findings were holosystolic mitral valve prolapse (MVP) in 20 subjects (57%) and mild aortic regurgitation in four subjects (11%). Of the 20 subjects with MVP, five had associated tricuspid valve prolapse, but none had notable mitral regurgitation. Thus, we found that the majority of asymptomatic adults with Down's syndrome had valvular heart abnormalities. The high frequency of MVP and aortic regurgitation suggests that these lesions may be specifically associated with Down's syndrome in adults. (<i>JAMA</i>1987;258:1793-1795)
Clinical stage draws nearer in ongoing studies of gene therapy
Authors: K. Simmons
Journal: JAMA (1985)

It may be a matter of three years or less before clinical trials are undertaken for the study of gene therapy of inherited disease. That is the estimation of C. Thomas Caskey, MD, director of the Robert J. Kleberg, Jr, Center for Human Genetics at Baylor College of Medicine, Houston. It is an opinion shared by numerous other investigators. (Two unsuccessful attempts to undertake gene transfer involving women with β<sup>0</sup>-thalassemia were performed abroad in 1980 by Martin J. Cline, MD, of the University of California, Los Angeles, School of Medicine. Although Cline had permission of the local hospitals abroad to perform the experiments, the UCLA institutional review board rejected his proposal on the grounds that further animal studies were needed, and he lost his National Institutes of Health grants.) Caskey, who spoke at the annual Short Course in Medical and Experimental Mammalian Genetics in Bar Harbor, Me, which
Progress Toward Tuberculosis Control— India, 2001
Journal: JAMA (2002)

Every year, approximately 2 million persons in India develop tuberculosis (TB), accounting for one fourth of the world's new TB cases. Organized TB control activities have existed in India for 40 years; however, the quality of diagnosis and treatment of TB in the public and private sectors has been variable, and TB incidence and prevalence trends have not changed substantially over this time. In 1992, the Indian government established a Revised National Tuberculosis Control Programme (RNTCP) using the directly observed treatment, short-course (DOTS) strategy recommended by the World Health Organization (WHO) (3). The DOTS strategy consists of sustained government commitment, effective laboratory-based diagnosis, standard treatment given under direct observation, secure drug supply, and systematic monitoring and evaluation. RNTCP was implemented in pilot areas beginning in 1993; large-scale implementation of the program began in late 1998. This report summarizes the process, outcomes, and challenges of RNTCP in India. RNTCP has implemented DOTS rapidly and has yielded positive results in TB control; however, continued commitment from Indian government authorities and the international community is needed to sustain and expand this ongoing program.
THE RELATION OF FUNCTIONAL DISORDERS OF THE HEART TO DISEASES OF THE ABDOMINAL VISCERA.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leveling with young people about sex
Authors: E. J. Lieberman
Journal: JAMA (1969)

In the minds of most parents the family physician qualifies as one of the few available experts on sex. As Harold Lief, MD, has pointed out (<i>Harper</i><b>229</b>:92 [Dec] 1964), this is one area where physicians are given too much credit. Most physicians are not adequately prepared to handle sex education with individuals or groups; but no one else is either, and the interested physician is in a good position to remedy the situation. <h3>Why Don't Parents Do It?</h3> It is a mistake to think that physicians, teachers, ministers, and others must handle sex education simply because too many parents have fallen down on the job. Even when parents do a good job, children will get information from other sources, and it is part of our responsibility to see that some of this is of good quality. If you ask parents who<i>have</i>done a good job, you will
Manual Therapy, Physical Therapy, or Care by Primary Care Doctors for Patients with Neck Pain
Journal: Annals of Internal Medicine (2002)

Summaries for Patients21 May 2002Manual Therapy, Physical Therapy, or Care by Primary Care Doctors for Patients with Neck PainSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-10-200205210-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Neck pain is common and can interfere with daily activities. Neck pain usually goes away without treatment, but patients often seek treatment to speed recovery. Treatments include pain medications, rest, manual therapy, and physical therapy. In manual therapy, a trained therapist moves a patient's neck in specific ways to help improve neck mobility. In physical therapy, a trained therapist assists patients with exercises to improve neck mobility. The main difference between manual therapy and physical therapy is that the therapist moves the patient in manual therapy, while physical ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Manual Therapy, Physical Therapy, or Continued Care by a General Practitioner for Patients with Neck Pain. A Randomized, Controlled Trial.” It is in the 21 May 2002 issue of Annals of Internal Medicine (volume 136, pages 713-722). The authors are JL Hoving, BW Koes, HCW de Vet, DAWM van der Windt, WJJ Assendelft, H van Mameren, WLJM Devillé, JJM Pool, RJPM Scholten, and LM Bouter.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians–American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoManual Therapy, Physical Therapy, or Continued Care by a General Practitioner for Patients with Neck Pain Jan Lucas Hoving , Bart W. Koes , Henrica C.W. de Vet , Danielle A.W.M. van der Windt , Willem J.J. Assendelft , Henk van Mameren , Walter L.J.M. Devillé , Jan J.M. Pool , Rob J.P.M Scholten , and Lex M. Bouter Metrics 21 May 2002Volume 136, Issue 10Page: I-36KeywordsArthralgiaBone fractureComputersEmotionsExerciseExercise therapyInflammationMusclesMyalgiaPatients ePublished: 21 May 2002 Issue Published: 21 May 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Impact of the Medicare fee schedule on payments to physicians
Authors: J. M. Levy
Journal: JAMA (1990)

Beginning in 1992, the Medicare program will pay physicians by the Medicare Fee Schedule, a system of geographically adjusted standardized payment rates based in part on the Resource-Based Relative Value Scale developed by Hsaio et al and in part on current Medicare payments. In our simulations of the Medicare Fee Schedule, we find that (1) redistributions of Medicare-allowed charges across specialities will be substantial but approximately only half the size projected by Hsaio, (2) there will be large redistributions among geographic areas that tend to compound the specialty redistributions, and (3) there will be wide variation within specialties as to how individual providers are affected. The majority of the redistributive impact of the Medicare Fee Schedule is attributable to implementation of a geographically adjusted system of standardized payments rather than to the particular work values developed by Hsiao et al in the Resource-Based Relative Value Scale. (<i>JAMA</i>. 1990;264:717-722)
Heberden Society: Annual General Meeting and Oration
Authors: Stephen Krane, A Parke, C Henby, P Gordon, G Hughes, Synovium Higgs, J Salmon, B Cashman, B Henderson, L Bitensky, J Chayen, J Vane.' ', J Delamere, D Scott, A Bradwell
Journal: Annals of the Rheumatic Diseases (1981)

This is the first report quantitating prostacyclin metabolites in inflammatory synovial fluid.Until now prostaglandin E2 (PGE2) has been considered to be the main proinflammatory chemical mediator in inflammatory joint disease.Our findings suggest that prostacyclin (PGI2) and its breakdown product 6-oxo-PGFIa are more important than PGE2.The significance of our findings is even more important considering that prostacyclin has been shown to promote bone resorption.'We measured the quantities of PGE2, PGF2oc and 6-oxo-PG1 a (a stable product of prostacyclin), and thromboxane B2 (a stable product of thromboxane A2) in 10 synovial fluids from 8 patients with inflammatory joint disease.The levels of 6-oxo- PGF1 a. (30 ± 44 ng/ml) were higher than the levels of PGE2 (5 7 ± 4.3 ng/ml) PGF2o (1 8 ± 0-8 ng/ml) and TXB2 (20 ± 23 ng/ml).Synovial fluid levels of 6-oxo-PGF1 x were 100 to 1000 times higher than simultaneous plasma levels.Our findings of high levels of prostacyclin break- down products in inflammatory synovial fluid and the work of others culturing rheumatoid synovial tissue2 suggest that this prostaglandin may be important in the pathogenesis of inflammatory joint diseases.
Why Sepsis Trials Fail
Authors: Woody Denham
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Dr Bone's Commentary concerning the failure of clinical trials evaluating new therapies in the treatment of sepsis was timely and thoughtful.<sup>1</sup>However, there are a few points that we would like to address that undoubtedly contributed to these disappointing clinical trials. Sepsis is difficult to diagnose early in its course prior to the development of end-organ dysfunction. In fact, end-organ dysfunction was an entry criterion in each sepsis study cited by Bone. This study design dictates that the major endpoints used to determine efficacy of anti-inflammatory therapy are the resolution of this dysfunction and (primarily) 28-day mortality. The prevention of end-organ failure, which would most likely have an impact on nearly all of the clinical features of sepsis, including survival, morbidity, and cost, is essentially not amenable to investigation using these trial protocols. Since mortality is directly attributable to the incidence and severity of multiple organ
Doctor Chekhov
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retroperitoneal sarcomas: patterns of care at diagnosis, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group
Authors: M. Toulmonde, S. Bonvalot, P. Méeus, E. Stoeckle, O. Riou, N. Isambert, E. Bompas, M. Jafari, C. Delcambre-Lair, E. Saada, A. Le Cesne, C. Le Péchoux, J.Y. Blay, S. Piperno-Neumann, C. Chevreau, J.O. Bay, V. Brouste, P. Terrier, D. Ranchère-Vince, A. Neuville, A. Italiano
Journal: Annals of Oncology (2014)
HOSPITAL AND DISPENSARY ABUSE.
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal