tbuckley/cabot-search huggingface dataset:
Curriculum Development for Medical Education: A Six-Step Approach
Authors: Susan L. Rattner
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes18 May 1999Curriculum Development for Medical Education: A Six-Step ApproachSusan L. Rattner, MD, MSSusan L. Rattner, MD, MSJefferson Medical College, Philadelphia, Pennsylvania. (Rattner)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-10-199905180-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Kern DE, Thomas PA, Howard DM, Bass EB. 178 pages. Baltimore: Johns Hopkins Univ Pr; 1998. $45.00. ISBN 0801858445. Order phone 800-537-5487.Field of medicine: Medical education.Format: Softcover book.Audience: Clinicians and scientists responsible for curriculum development at the program and course level for all levels of medical education. It is a succinct introduction for planners who have not had formal training as educators and who are new to planning roles.Purpose: To provide a brief, practical guide to the iterative process of curriculum development, implementation, and evaluation.Content: A conceptual overview is provided in the first chapter. Six ... Author, Article, and Disclosure InformationAffiliations: Jefferson Medical College, Philadelphia, Pennsylvania. (Rattner) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPeriodic Trends in a Simulated Water Treatment Station: A Methodology to Engage Students in the Lower Levels of Inorganic Chemistry Learning 18 May 1999Volume 130, Issue 10Page: 867KeywordsComputer softwareMedical educationResidencyScientists ePublished: 15 August 2000 Issue Published: 18 May 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Diagnosing Hypertension in Children and Adolescents—Reply
Authors: Matthew L. Hansen, Paul W. Gunn, David C. Kaelber
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Authors: K Hamilton, B Lee, R Miranda, R Steinbrook
Journal: JAMA Internal Medicine (2014)

New research shows that Americans have had at least 14 million major medical conditions that were the result of cigarette smoking.Using publicly available data sources, Rostron and colleagues estimated smoking-attributable morbidity in the United States.Chronic obstructive pulmonary disease represents the leading cause of smoking-attributable disease in the United States, with an estimated 7.5 million current and former smokers having the condition because of cigarette use, followed by 2.3 million people having had myocardial infarctions because of smoking.These results demonstrate that smoking continues to be the leading cause of preventable disease in the United States and that vigorous public health efforts are needed to reduce this health burden.Schroeder provides an Invited Commentary.
Severe metabolic alkalosis: a case report.
Journal: BMJ (1981)

hepatitis B virus, disordered tryptophan meta- bolism:' has been claimed to play a role in Indian childhood cirrhosis.We found no evidence for this in our patients and we know of no other workers who have corroborated the findings of Sur and Bhatti.:IIt may well be that the disease encompasses a heterogeneous group of disorders with certain clinical and histological features in common.Residence outside the Indian subcontinent, as in our patients, may modify these features.It is now clear that the diagnosis of Indian childhood cirrhosis should be considered in any infant or child-whatever the age-of appropriate racial origin who presents with chronic liver disease.Definitive treatment is lacking and we agree that a trial of penicillamine is urgently required in a disease with such a miserable prognosis.
Preliminary Results of Daratumumab, Cyclophosphamide, Thalidomide and Dexamethasone: A Quadruplet Intensified Treatment for Newly Diagnosed Multiple Myeloma (NDMM) Transplant Eligible (TE) Patients
Authors: Edvan De Queiroz Crusoe, Marco Aurelio Salvino, Sarah Queiroz Silva, Herbert Henrique de Melo Santos, Allan de souza Santos, Alessandro de M. Almeida, Lucas de Oliveira Vieira, Cleverson Alves Fonseca, Larissa Ferreira Lucas, Joanna Leal, Mariane Melo Santos, Juliana Andrade Santos, Elisangela Adorno, Vania T. M. Hungria, Maria da Gloria B. Arruda
Journal: Blood (2020)
International Clinics; a Quarterly of Clinical Lectures on Medicine, Neurology, Surgery, Genito-urinary Surgery, Gynecology, Obstetrics, Ophthalmology, Laryngology, Pharyngology, Rhinology, Otology and Dermatology.
Journal: JAMA (1894)

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Community-based health care for the homeless
Authors: R. Voelker
Journal: JAMA (1994)

IN THE SPRAWLING, urban-and-rural landscape of Arizona's Maricopa County, homeless people wouldn't get far on the $15 000 in local funds allocated this year for a program of integrated services, including medical and psychiatric care. "We are one of the fastest-growing counties in the country, but we are one of the poorest in funds for indigent health care," says Julie Marshall, administrator of the Maricopa County Health Care for the Homeless program, which serves Phoenix and surrounding areas. The bulk of the program's $1.1-million annual budget comes from the federal Health Care for the Homeless (HCH) program sponsored by the Health Resources and Services Administration (HRSA), Rockville, Md. Through the Division of Programs for Special Populations within its Bureau of Primary Care, the HRSA doles out $58 million annually to 120 community-based organizations working to provide integrated primary medical care, mental health services, and substance abuse treatment while establishing an
Migration and granulomatous reaction after periurethral injection of polytef (Teflon)
Authors: A. A. Malizia
Journal: JAMA (1984)

Although patients with urinary incontinence have been treated successfully by periurethral injection of polytef paste, this study in continent animals demonstrates migration of polytef particles from the injection site. We injected polytef paste periurethrally into female dogs and male monkeys. Particles were found at 50 to 70 days in pelvic nodes in six of seven animals and lungs in four of seven (the kidneys and brain were not studied); and at 10 1/2 months in pelvic nodes, lungs, and brain in seven of seven; kidneys in four of seven; and spleen in two of seven. X-ray microanalysis confirmed that the particles were polytef. At 10% months, polytef granulomas were found at all injection sites and some sites of distant migration. Since these granulomas signify chronic foreign-body reaction, we believe that until the long-term effects in humans are known, polytef paste should not be used in children or young adults with normal life expectancy. (<i>JAMA</i>1984;251:3277-3281)
ATP site-directed competitive and irreversible inhibitors of protein kinases
Authors: Carlos García-Echeverría, Peter Traxler, Dean B. Evans
Journal: Medicinal Research Reviews (2000)

Several tyrosine and serine/threonine protein kinases have emerged in the last few years as attractive targets in the search for new therapeutic agents being applicable in many different disease indications. Initially, inhibition of these protein kinases by ATP site-directed inhibitors was considered less prone to success, but medicinal chemists from both academia and industry have been able to impart potency and selectivity to a limited number of scaffolds by modulating and fine-tuning the interactions of the modified template with the ATP binding site of the selected kinase. The chemical templates that have been used in the synthesis of ATP site-directed protein kinase inhibitors are reviewed with emphasis on the kinase inhibitors that have entered or are about to enter clinical trials. Examples have been selected to illustrate how structure-based design approaches and new methods to increase compound diversity have had an impact on this area of research. © 2000 John Wiley & Sons, Inc. Med Res Rev, 20, No. 1, 28–57, 2000
In Reply:
Authors: Angela Gradilone, Paola Gazzaniga, Diego Ribuffo, Susanna Scarpa, Emanuele Cigna, Fortunata Vasaturo, Ugo Bottoni, Daniele Innocenzi, Stefano Calvieri, Nicolò Scuderi, Luigi Frati, Anna Maria Aglianò
Journal: Journal of Clinical Oncology (2004)
Gastrointestinal Physiology
Authors: R. Thomas Holzbach
Journal: JAMA (1978)

This is a brief but well-integrated survey of a vast subject, written by five authors who have had extensive research experience with the areas to which they contribute. The text aims to provide a primer for medical students and beginning graduate students. To this end its objective has been admirably well met, as I have yet to encounter a more lucidly written or better edited presentation. The authors have made a particular effort to emphasize clinical implications in the material under discussion. As is inevitable when sketching on such a broad canvas, there are some minor scattered errors or at least misleading statements (eg, unconjugated secondary bile acids are probably<i>not</i>primarily formed in the small intestine and initially reabsorbed by the terminal ileum), but these, in general, detract little from the whole. Also, while some chapters are well referenced with excellent current reviews, others fall far short of this
Tuberculosis in Europe During and After the Second World War.--II
Authors: M. Daniels
Journal: BMJ (1949)

alarming stimulus during a period of one to two days it usually flares up in a particularly severe form upon dis- continuation of the stress-e.g., cold, muscular exercise.lndeed, sometimes the arthritis developed after a latency period even if the stress was continued.Such observations raise the question whether it will be possible to combat clinical " diseases of adaptation " indefinitely by continued A.C.T.H. or cortisone therapy. Summary and ConclusionsA technique has been developed which permits the produc- tion of an acute arthritis and periarthritis by the local injection of for.naldehydeinto the vicinity of joints.If large doses of.formaldehyde are administered the acute stage is followed by a very prolonged chronic arthritis and periarthritis, charac- terized by moderate oedema and very pronounced connectivetissue proliferation, with stiffening of the joint and hyperaemia of the surrounding skin.The resulting chronic granuloma is self-maintaining, as it continues to proliferate for weeks after the administration of the local irritant.This "formalin-arthritis " is slightly aggravated by pre- treatment with desoxycortone or crude anterior-pituitary preparations; on the other hand it can be almost completely inhibited by cortisone or A.C.T.H.Thus there seems to exist an antagonistic relationship between D.C.A. or crude anterior- pituitary preparations on the one hand and cortisone or purified A.C.T.H. on the other.The possible role of such an antagonism is discussed in connexion with the concept of "crossed resistance" and of the "diseases of adaptation."This investigation was performed with the aid of a grant from the Canadian National Research Council.I am also indebted to the following companies, who supplied the hormone preparations necessary for this work:
AMA-RPS chairperson looks back
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of brain death and glucose infusion on hepatic glycogen and blood hormones in the pig
Authors: K Roelsgaard
Journal: Hepatology (1996)

We wished to study the effects of intravenous glucose/ insulin infusion to brain-dead pigs on the hepatic glycogen content. Four groups of 40- kg pigs were studied: brain-dead and control pigs given isotonic saline or glucose/insulin (7.5 mg glucose/kg/min, 1.25 mU insulin/kg/ min) (n = 5 to 10 in each group). Brain death was induced by inflating a balloon placed in the epidural space. In brain-dead pigs given saline, liver glycogen decreased from 45 ± 11 mmol/g DNA (mean ± SEM) to 7 ± 3 mmol/ g DNA after 6 hours. Thereafter, it increased to 28 ± 9 mmol/g DNA after 9 hours (P = .05 compared with the 6-hour measurement). These changes were accompanied by transient increases in plasma adrenaline, glucose, free fatty acids (FFA), and glucagon. Following glucose/ insulin infusion, hepatic glycogen increased steadily and was approximately double after 12 hours (P < .01) in both brain-dead and in non-brain-dead pigs. In brain-dead pigs, the increases in the aforementioned blood measurements were smaller following glucose/insulin infusion than following saline infusion. However, studies of longer duration will be needed to examine these effects on a time scale that is relevant to human organ donors. In conclusion, the decrease in hepatic glycogen content after brain death could be prevented by intravenous glucose/insulin infusion probably because of a reduction of the adrenaline response to the induction of brain death.
In Brief
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"THE REPORTING OF VENEREAL DISEASES BY PHYSICIANS"
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ST Elevation Acute Coronary Syndromes in PLATO
Authors: Paul W. Armstrong, Hany Siha, Yuling Fu, Cynthia M. Westerhout, P. Gabriel Steg, Stefan K. James, Robert F. Storey, Jay Horrow, Hugo Katus, Peter Clemmensen, Robert A. Harrington, Lars Wallentin
Journal: Circulation (2011)
Effects of Carvedilol, a Vasodilator–β-Blocker, in Patients With Congestive Heart Failure Due to Ischemic Heart Disease
Journal: Circulation (1995)

Background β-Blocker therapy has been shown to increase ejection fraction in patients with heart failure of idiopathic etiology. However, in patients with heart failure of ischemic etiology, the effects of this treatment on left ventricular function remain uncertain, as do the effects on exercise performance and symptoms. Methods and Results This study investigated the effects of carvedilol, a β-blocker with α 1 -blocking properties, on left ventricular size and function, maximal and submaximal exercise performance, and symptoms in 415 patients with stable heart failure of ischemic etiology (ejection fraction &lt;45%). After a 2- to 3-week run-in phase on open-label low-dose carvedilol, patients were randomized to continued treatment with carvedilol (up to 25 mg BID) or to matching placebo. After 6 months, left ventricular ejection fraction measured by radionuclide ventriculography had increased by 5.2% ( 2P &lt;.0001) in the carvedilol group compared with the placebo group, and left ventricular end-systolic and end-diastolic dimensions measured by two-dimensionally guided M-mode echocardiography had decreased by 2.6 mm ( 2P =.0005) and 1.3 mm ( 2P =.05), respectively. There were no significant changes in either treadmill exercise duration or 6-minute walk distance between carvedilol and placebo groups (both 2P &gt;.1); in the carvedilol group, exercise performance was therefore maintained with a 23% lower rate-pressure product. Symptoms assessed by the New York Heart Association (NYHA) scale and the Specific Activity Scale (SAS) were unchanged in two thirds of patients in both groups, but there was a small excess of patients whose symptoms worsened and a deficit of patients whose symptoms improved among those assigned carvedilol (NYHA, 2P =.05; SAS, 2P =.02). Conclusions In patients with heart failure of ischemic etiology, 6-month treatment with carvedilol improved left ventricular function and maintained exercise performance at a lower rate-pressure product, but symptoms assessed by functional class were slightly worsened. A larger-scale trial is now required to determine whether this treatment will reduce serious morbidity and mortality from heart failure.
Failure of computed tomographic scanning to demonstrate subdural empyema
Authors: R. O. Dunker
Journal: JAMA (1981)

Subdural empyema is a serious infection with a high mortality. The patients at risk either are known to have suppurative sinusitis or otitis or are being treated for these conditions. The clinical syndrome includes fever, headache, and focal neurological deficits, with seizures in a high percentage of cases. The course of the infection may be fulminant and may be confused with meningoencephalitis or cerebritis. Early diagnosis and surgical intervention are essential elements in treatment. There is a disturbing tendency for computed tomographic (CT) scans to fail to demonstrate acute subdural empyemas. Based on this experience, the diagnosis of subdural empyema must not be abandoned merely because of a nondiagnostic CT scan. (<i>JAMA</i>1981;246:1116-1118)
IS THE APOTHECARY SHOP DOOMED?
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal