tbuckley/cabot-search huggingface dataset:
Dihydrotestosterone Suppresses Foam Cell Formation and Attenuates Atherosclerosis Development
Authors: Yang Qiu, Toshihiko Yanase, Haidi Hu, Tomoko Tanaka, Yoshihiro Nishi, Min Liu, Katsuo Sueishi, Tatsuya Sawamura, Hajime Nawata
Journal: Endocrine Reviews (2010)

ABSTRACT The role of testosterone in atherosclerosis remains unclear because it is aromatized to estrogen. We investigated the effect of the nonaromatized natural androgen 5α-dihydrotestosterone (DHT) on the rabbit atherogenesis in relation to the proatherogenic molecule lectin-like oxidized-low-density lipoprotein receptor-1 (LOX-1) and its downstream molecules. Thirty-nine male New Zealand white rabbits were divided into four groups: 1) noncastrated group with normal chow diet (n = 6); 2) noncastrated group with high-cholesterol diet (HCD) (n = 10); 3) castrated group with HCD plus sc placebo pellet (n = 11); and 4) castrated group with HCD plus sc 150 mg DHT pellet (n = 12). Implantation of sc DHT or placebo pellet was performed at the time of castration. After castration or sham operation, the rabbits were fed the HCD for 8 wk, and plaque areas were assessed in the entire aorta. The HCD-induced increase in plaque area, which was most aggravated in the castration plus placebo group, was attenuated in the castration plus DHT group. Microscopic examination of the proximal descending aorta revealed that DHT significantly reduced HCD-induced foam cell formation, which was mostly composed of macrophages in the intima layer, compared with the placebo group. The decreased accumulation of foam cells with DHT treatment was accompanied by a marked reduction in the expression of LOX-1 mRNA in these cells. In cultured macrophages prepared from male wild-type mice that express the androgen receptor (AR), 1 × 10−8m and 1 × 10−9m DHT inhibited the formation of foam cells induced by oxidized low-density lipoprotein. Moreover, the expression of LOX-1 and inflammatory cytokines in the cultured macrophages was significantly suppressed by DHT. Such suppressive effects of DHT on foam cell formation and cytokine expression were not observed in cultured macrophages prepared from male AR-null mice, suggesting an involvement of AR in the mechanism. In conclusion, physiological levels of DHT attenuated the development of atherosclerosis in rabbits through the suppression of intimal foam cell formation of macrophage partly via the suppression of LOX-1 expression.
Annual Meeting of the American Society of Preventive Oncology
Journal: JNCI Journal of the National Cancer Institute (1987)

Journal Article Annual Meeting of the American Society of Preventive Oncology Get access JNCI: Journal of the National Cancer Institute, Volume 78, Issue 1, January 1987, Page 195, https://doi.org/10.1093/jnci/78.1.195-b Published: 01 January 1987
Marrow Examination
Authors: David A. Mulkey
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The case report "Chlorpropamide-Induced Agranulocytosis" (238:422, 1977) contains a deficiency. Description of hypocellular marrow on bone marrow aspiration, with a photograph (Fig 2) of marrow diluted by peripheral blood, hardly documents "a marked reduction in the myeloid series." The necessity of marrow sectioning in assessing aplasia is well known,<sup>1</sup>and the techniques and advantages of marrow coring are well described.<sup>2</sup>Marrow aplasia as a cause for inadequate marrow aspiration is far less common in our experience than lymphoma, hairy cell disease, fibrosis, or replacement by tumor.
THE DANGER OF BURIAL ALIVE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply: Estimation of Relative Risk From Vital Data: Smoking and Cancers of the Lung and Bladder
Authors: Richard G. Stevens, Suresh H. Moolgavkar
Journal: JNCI Journal of the National Cancer Institute (1981)

Reply: Estimation of Relative Risk From Vital Data: Smoking and Cancers of the Lung and Bladder Get access Richard G. Stevens, Richard G. Stevens Institute for Cancer Research Philadelphia, Pennsylvania 19111. Search for other works by this author on: Oxford Academic PubMed Google Scholar Suresh H. Moolgavkar Suresh H. Moolgavkar Institute for Cancer Research Philadelphia, Pennsylvania 19111. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 66, Issue 4, April 1981, Pages 612–613, https://doi.org/10.1093/jnci/66.4.612 Published: 01 April 1981
<i>Erratum</i>: Vol. 66, No. 17 <i>Vital Signs</i>: Racial Disparities in Age-Specific Mortality Among Blacks or African Americans — United States, 1999–2015
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

1) (Data In, Intelligence Out [https://www.diio.net],unpublished data, 2016)."
Credentialing in an era of change
Authors: W. S. Grundfest
Journal: JAMA (1993)

The article by See et al<sup>1</sup>in this issue provides documentation of the value of postresidency training, skilled associates, and the development of a surgical team in the introduction of new techniques for minimally invasive surgery. It also calls attention to the wide variation in granting of privileges, which should set the standards for clinical training required for the performance of these new techniques. Although surgeons have always understood the value of learning from those more skilled in the art, well-researched documentation of the value of this approach with respect to its efficacy in postresidency training has been lacking. The recent introduction of laparoscopic surgery has forced a massive educational effort within general surgery, urology, gynecology, and thoracic surgery. However, the privileging criteria for each of these disciplines have lagged behind the adoption of new surgical techniques and procedures. See also p 2689. There is significant variation in the
Chlamydia screening
Journal: BMJ (2011)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Chlamydia screening Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Penicillin
Authors: J. W. Bennett
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhalation and nasal challenge in the diagnosis of aspirin‐induced asthma
Authors: A. Pawlowicz, W. R. Williams, B. H. Davies
Journal: Allergy (1991)

Inhalation and nasal aspirin challenge has been investigated in asthma patients with co‐existing rhinitis. Eight of 39 asthma patients were diagnosed as aspirin‐sensitive on the basis of inhalation challenge. Seven aspirin‐sensitive asthmatics were subjected to nasal aspirin provocation. During nasal challenge, all seven patients experienced a fall in FEV, of at least 15%, two showed a significant increase (&gt; 400%) in nasal airways resistance (NAR) and one developed urticaria. No significant changes in FEV 1 or NAR were observed in nine normal subjects after aspirin inhalation and nasal challenge. There were no significant changes in FEV 1 or NAR in six aspirin‐tolerant asthmatics when aspirin was given intranasally. The results of this study show that aspirin nasal provocation impairs lung function in aspirin‐sensitive asthmatics. In comparison with inhalation challenge responses are generally milder and easier to control. Nasal challenge is also less time‐consuming than other methods of aspirin challenge and is therefore more suitable for routine use.
Pseudotumor Cerebri
Authors: Varun K. Saxena
Journal: JAMA (1976)

SINCE THE advent of intravenous hyperalimentation through the subclavian vein, a number of complications have come to light. Pseudotumor cerebri developed in a 19-year-old woman as a result of thrombosis of the internal jugular vein and left transverse sinus. This was treated successfully with steroids and anticoagulants. <h3>Report of a Case</h3> A 19-year-old woman was admitted with complaints of lower-abdominal cramping pain and intermittent, nonbloody diarrhea for one year. Six weeks prior to admission, she had noticed an enlarging mass in the right lower quadrant, and during this period she lost 11.4 kg. She was pale, slightly emaciated, and dehydrated, and in moderate distress. Her pulse rate was 100 beats per minute and regular, and her temperature was 38.6 C. A 6×5-cm, ill-defined, nonfluctuant, tender mass was palpable in the right lower quadrant. The liver and spleen were not palpable and there were no other intra-abdominal masses. There was tenderness
Patient's Personality, Life Experience Traced as Causes Of the Chronic Headache
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Empire Rheumatism Council. Cortisone/Aspirin Trial: Multi-Centre Controlled Trial Comparing Cortisone Acetate and Acetyl Salicylic Acid in the Long-Term Treatment of Rheumatoid Arthritis
Journal: Annals of the Rheumatic Diseases (1955)

1) INTRODUCTIONIn the last 6 years cortisone acetate (hereafter designated "cortisone") has been widely used in the treatment of rheumatoid arthritis, but of the numerous studies made on a sufficiently wide scale, only two have made a controlled comparison over a prolonged period between this treatment and another.Both of these trials were carried out at a number of centres in Great Britain under the auspices of the Medical Research Council and the Nuffield Foundation.One dealt with the use of cortisone as an adjuvant to manipulation compared with tablets of aspirin, codeine, and phenacetin (Medical Research Council and Nuffield Founda- tion, 1954).The second trial compared cortisone with aspirin in the treatment of early cases of rheumatoid arthritis of less than 9 months' duration at the start of treatment (Medical Research Council and Nuffield Foundation, 1954b, 1955).Neither of these trials showed any striking advantage of cortisone over salicylate medication.These results coincided with the publication of the only controlled trial of hormones and aspirin in rheumatic fever
Impact of gamma and beta radiation vs. Placebo on the changing pattern of in-stent restenosis: A matched angiographic analysis Alexandra J. Lansky, Roxana Mehran, Kartik Desai, Costantino Costantini O., Brian Proctor, Teraza Conway, Martin Fahy, George Dangas, Gregg W. Stone, Ron Waksman, Jeffrey W. Moses, Martin B. LEon. Cardiovascular Research Foundation, New York, NY
Journal: Journal of the American College of Cardiology (2001)
Book Reviews
Journal: Allergy (1986)

Book reviews in this article: Venge, P. &amp; Lindbom, A. (eds.): Inflammation. Basic mechjinisms, tissue injuring principles, clinical models. Kay, A. B. (ed.) : Asthma. Clinical pharmacology and therapeutic progress Mygind, N. : Essential allergy Oppenheim, J. J. &amp; Jacobs, D. M. : Leukocytes and host defense: Progress in leukocyte biology.
Council on drugs. List No. 86. New names
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of Vitamin B6 Is Analyzed In Central Nervous System Disorders
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DOES NOT TAKE A JOKE.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors' Reply
Authors: Iain C. Macdougall, Ian Ford
Journal: Journal of the American Society of Nephrology (2020)

On behalf of the entire Proactive IV IrOn Therapy in HaemodiALysis Patients (PIVOTAL) study team, we wish to thank Kshirsagar et al.1 for their comments on our recently published secondary analysis of the PIVOTAL trial.2 We agree with much of what they have said but have the following comments to make. The choice of dosing regimens and safety cutoffs for the two arms in the PIVOTAL trial has been extensively discussed. We completely recognize that a large number of dialysis centers in the United States are already using iron protocols that are aligned to the high-dose arm.3 However, it is important to point out that current clinical practice varies widely worldwide, and the majority of countries and dialysis centers adopt more modest iron dosing protocols than the United States. Indeed, in Japan, the standard of care is more aligned to the low-dose arm of the trial.3,4 The trial was originally designed to reflect the two extremes of iron dosing in the United Kingdom, and indeed, comprehensive pretrial research indicated that a ferritin safety cutoff >700 μg/L would not be acceptable to many potential investigators in the United Kingdom. We already recognized that the sample size for the study would need to be >2000 patients and that we would need “buy-in” from 40–50 centers. Thus, the choice of dosing protocols in the study was partly on the basis of current United Kingdom and European practice and partly on a pragmatic approach regarding study feasibility. Next, we agree with Kshirsagar et al.1 that the two options that dialysis physicians in the United States have are (1) to continue with their more aggressive iron protocols, aiming to rigorously test the benefits/safety of this approach (particularly because in the authors’ own observational study of 13,249 United States patients on dialysis, intravenous iron administration strategies promoting more intensive iron treatment were associated with higher risks of mortality and infection-related events5); or (2) adopt the PIVOTAL high-dose arm approach with the corollary that dosing strategies more or less aggressive than this be halted. Which of these options to choose is not within our remit to comment, but we feel that this is where we need to defer to guideline bodies, such as Kidney Disease Improving Global Outcomes, to assess the evidence base and make recommendations because they have the expertise and methodology to do this properly. Disclosures I. Ford has received research grants from Vifor Pharma and Pharmacosmos. I. Macdougall has received speaker fees, honoraria, and consultancy fees from several ESA and IV iron manufacturers, including Akebia, AMAG, Astellas, Bayer, FibroGen, GlaxoSmithKline, Pharmacosmos, and Vifor Pharma. Funding None.
Association between Ozone and Asthma Emergency Department Visits in Saint John, New Brunswick, Canada
Authors: David M. Stieb, Richard T. Burnett, Robert C. Beveridge, Jeffrey R. Brook
Journal: Environmental Health Perspectives (1996)

This study examines the relationship of asthma emergency department (ED) visits to daily concentrations of ozone and other air pollutants in Saint John, New Brunswick, Canada. Data on ED visits with a presenting complaint of asthma (n = 1987) were abstracted for the period 1984-1992 (May-September). Air pollution variables included ozone, sulfur dioxide, nitrogen dioxide, sulfate, and total suspended particulate (TSP); weather variables included temperature, humidex, dewpoint, and relative humidity. Daily ED visit frequencies were filtered to remove day of the week and long wave trends, and filtered values were regressed on air pollution and weather variables for the same day and the 3 previous days. The mean daily 1-hr maximum ozone concentration during the study period was 41.6 ppb. A positive, statistically significant (p < 0.05) association was observed between ozone and asthma ED visits 2 days later, and the strength of the association was greater in nonlinear models. The frequency of asthma ED visits was 33% higher (95% CI, 10-56%) when the daily 1-hr maximum ozone concentration exceeded 75 ppb (the 95th percentile). The ozone effect was not significantly influenced by the addition of weather or other pollutant variables into the model or by the exclusion of repeat ED visits. However, given the limited number of sampling days for sulfate and TSP, a particulate effect could not be ruled out. We detected a significant association between ozone and asthma ED visits, despite the vast majority of sampling days being below current U.S. and Canadian standards.