tbuckley/cabot-search huggingface dataset:
Abstract 669: ET <sub>A</sub> Receptor Activation and ET <sub>B</sub> Receptor Deficiency Reduce Circulating Endothelial Progenitor Cells in Salt-Sensitive Hypertension
Authors: Dan-Dan Chen, Xiao-Ling Dai, Melissa W Li, James J Galligan, Gregory D Fink, Alex F Chen
Journal: Circulation (2007)

Background: Circulating endothelial progenitor cells (EPCs) are reduced in hypertension that correlates inversely with its mortality, but the mechanisms are poorly understood. DOCA-salt and ET B receptor deficiency rats (ET B −/ −) have salt-sensitive hypertension, characterized by increased ET-1 and oxidative stress levels. We hypothesized that ET A receptor activation and ET B receptor deficiency reduce circulating EPCs in adult male DOCA-salt rats. Methods and Results: Systolic blood pressure (SBP) was higher in DOCA-salt (4-wk regimen) vs. Sham rats (199.3 ± 4.8 vs. 133.4 ± 4.6 mmHg, n =8 –15, p&lt;.05), which was significantly reduced by in vivo treatment with ET A antagonist ABT-627 (5 mg/kg/d) or NADPH oxidase inhibitor apocynin (1.5 mmol/L) (167.8 ± 6.8 and 156.9 ± 16.6 mmHg, respectively). Flow cytometry showed that circulating CD34- and Flk-1-positive EPCs were significantly lower in DOCA vs. Sham rats (31.5 ± 0.2 vs. 18.3 ± 0.8% and 21.1 ± 0.9 vs. 16.3 ± 0.7%, respectively, n=7– 8, p&lt;.05). Dil-acLDL and isolectin double-stainings also showed reduced EPCs in DOCA vs. Sham rats (4.5 ± 0.4 vs. 10.2 ± 0.3 cells/hpf, n=5–15, p&lt;.01), which was rescued by in vivo treatment with ABT-627 (10.1 ± 1.7) or apocynin (8.9 ± 0.8). Real-time RT-PCR and fluorescence confocal microscopy showed that ET A and ET B receptor mRNA and proteins were present in EPCs of SD rats. Intracellular ROS level was increased by &gt;50% in EPCs of DOCA vs. Sham rats (DCF fluorescence, n = 9 –11, p&lt;.05). Apoptosis was increased by &gt;80% in EPCs of DOCA vs. Sham rats, which was reversed by ABT-627 or apocynin (TUNEL assay, n=5– 6, p&lt;.05). EPCs were significantly lower in ET B −/ − vs. ET B +/+ rats (6.3 ± 0.6 cells/hpf, n =7– 8), paralleled with higher SBP (telemetry 151 ± 1.2 vs. 129 ± 0.9 mmHg, n = 6), plasma ET-1 level (5.2 ± 0.3 vs. 3.6 ± 0.1 pg/ml, n = 5–12), and suppressed telomerase activity (354.6 ± 105.5 vs. 83.3 ± 26.2%, n = 3) (all p&lt;.05). ET-1 treatment (10 nM, 48 hrs) also reduced EPCs of normal rats (6.9 ± 0.1 vs. 10.3 ± 0.3 cells/hpf, n = 5– 6, p&lt;.05), which was rescued by ABT-627 (9.9 ± 0.3), but not by ET B antagonist BQ788 (7.6 ± 0.4). Conclusion: ET A activation and ET B deficiency reduce circulating EPCs in DOCA-salt and ET B −/ − rats, in part, due to NADPH oxidase-induced oxidative stress, apoptosis, and telomerase inactivation.
Cyclophosphamide--hemorrhagic cystitis following prolonged low-dose therapy
Authors: M. D. Bischel
Journal: JAMA (1979)

<h3>In Reply.—</h3> Guanidine is neither a cure for botulism nor has it helped all patients with botulism. That it has helped some patients with botulism is now documented in the world literature. In deciding whether or not to treat the patient with guanidine, the clinician might consider the following. Of the reported cases from this country and overseas, three times as many patients benefited from guanidine as those who did not. None of the botulism patients treated with guanidine suffered any irreversible side effects from the drug. The treatment time using guanidine is usually less than one month. As with any drug therapy, one must be alert to the possibility of serious side effects. If the drug is administered, one should obtain blood counts and tests of liver and renal function. Respiratory weakness remains the most resistant to reversal by guanidine. We have stressed this repeatedly in
Psychodynamic aspects of oral contraception. A review
Authors: E. E. Wallach
Journal: JAMA (1968)

Emotional response to use of oral contraceptives results from numerous factors, basic among them are the attitudes of patient and husband towards (1) contraception, (2) pregnancy, and (3) sexuality. Concerns over potential side effects, subsequent fertility, and use of any medication are significant, as well as information received from the patient's physician, peers, and news media. The estrogenic and progestogenic components of oral contraceptives have been implicated in emotional alterations. Varied cyclic changes occurring throughout the menstrual cycle depend greatly upon metabolic effects and fluctuating levels of estrogens and progesterone. Therapeutic value has been attributed to oral contraceptives in management of psychiatric conditions, although depression has also been described in association with their use. Libido does not appear to be affected by these drugs.
In the wake of Hurricane Andrew
Authors: S. McDonnell
Journal: JAMA (1995)

<h3>In Reply.</h3> —I appreciate the clarifications offered by Drs McDonnell and Hlady to statements made by people I interviewed. I also wish to offer a clarification or two. First, estimates of deaths attributable to Hurricane Andrew ranged from 13 to nearly 100, depending on the definition of cause being used (eg, do heart attacks occurring during cleanup operations count?). I used the number preferred by those close to the situation whom I interviewed, but have no argument with the "official" figure of 14 (13 and 15 have also been reported). As for the real or perceived threat of infection from<i>Han</i><i>tavirus</i>or other agents after the storm, my article addressed the possible threat and did not indicate that any outbreaks occurred. As for the usefulness of mass immunization, I am aware that opinion in the scientific community is split; indeed, an epidemiologist of my acquaintance believes that mass immunization
Ventricular Fibrillation
Authors: Kenneth A. Altman
Journal: JAMA (1964)

VENTRICULAR FIBRILLATION is almost always a fatal arrhythmia. In recent years, under closely supervised conditions and with the aid of electrical apparatus such as defibrillators and pace makers, there has been a marked increase in the saving of life in those in whom this arrhythmia has developed.<sup>1</sup>The rare occurrence of ventricular fibrillation in a middle-aged female without any history of previous heart disease or any evidence of it after careful investigation prompted the report of this case. <h3>Report of a Case</h3> The patient is a 52-year-old white female previously in excellent health until the day of admission (April 28, 1962) when she awoke and then "fainted" while still in bed. There was no incontinence or tongue biting. Shortly thereafter, another episode occurred during which time the patient was observed to "have shaken all over." The unconsciousness lasted a few minutes. On awakening the patient was sweaty and flushed.
I am 56 years old and have been in medicine for 33 years. I have worked in the United Kingdom since 1980 and have done jobs in general medicine, chest medicine, and geriatrics. During my rotation in medicine I also worked in subspecialties such as cardiology, diabetes, and gastroenterology. I have full membership of the Royal College of Physicians, and two years ago I was awarded a fellowship. In my current job I do a diabetes clinic for the independent elderly and non-invasive cardiology. I am…
Authors: Bill Irish
Journal: BMJ (2006)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
Morphogenesis of Pulmonary Emphysema
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Correction
Journal: BMJ (1904)

rial reduction can be made in the number of medical officers in India nor, for the present at least, in South Africa, and the medical needs of the proposed big d6p6ts of the General- Service Army and of the territorial battalions of the Home- fService Army must be met.If the medical and sanitary work of the army abroad and at home is to be properly done, the establishment of the Army Medical Service cannot be reduced.The Corps is still short of officers and men, and if the recommendations of the various Royal Commissions still
Metabolism of Inorganic Arsenic in Children with Chronic High Arsenic Exposure in Northern Argentina
Authors: Gabriela Concha, Barbro Nermell, Marie Vahter
Journal: Environmental Health Perspectives (1998)

This study concerns the metabolism of inorganic arsenic (As) in children in three villages in northern Argentina: San Antonio de los Cobres and Taco Pozo, each with about 200 microg As/l in the drinking water, and Rosario de Lerma, with 0.65 microg As/l. Findings show that the concentrations of As in the blood and urine of the children in the two As-rich villages were on average 9 and 380 microg/l, respectively, the highest ever recorded for children. The concentrations were about 10 and 30 times higher for blood and urine, respectively, than in Rosario de Lerma. Total As in urine was only slightly higher than the sum of metabolites of inorganic As (U-Asmet), i.e., inorganic As, methylarsonic acid (MMA), and dimethylarsinic acid (DMA); this shows that inorganic As was the main form of As ingested. In contrast to previous studies on urinary metabolites of inorganic As in various population groups, the children and women in the present study excreted very little MMA. Thus, there seems to be a polymorphism for the enzymes (methyltransferases) involved in the methylation of As. Interestingly, the children had a significantly higher percentage of inorganic As in urine than the women, about 50% versus 32%. Also, the percentage of inorganic As in the children is considerably higher than in previous studies on children (about 13% in the two studies available) and adults (about 15-25%) in other population groups. This may indicate that children are more sensitive to As-induced toxicity than adults, as the methylated metabolites bind less to tissue constituents than inorganic As. In the children, the percentage inorganic arsenic in urine decreased, and the percentage of DMA increased with increasing U-Asmet, indicating an induction of As methylation with increasing exposure.
<i>Rest, Suggestion and other Therapeutic Measures in Nervous and Mental Diseases</i>. By Francis X. Dercum, A. M., M. D., Ph. D., Professor of Nervous and Mental Diseases in the Jefferson Medical College, Philadelphia, etc. Second edition. (<i>Philadelphia: P. Blakiston's Sons &amp; Co., 1917</i>.)
Journal: American Journal of Psychiatry (1918)
Kath
Authors: H.J.C. Swan
Journal: Annals of Internal Medicine (1992)

On Being a Doctor15 December 1992KathH.J.C. Swan, MD, PhDH.J.C. Swan, MD, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-12-1049 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNineteen ninety-two has been a strange year for funerals. Not a heart death among them. Six in all. All solid tumor. Two lungs. Two breasts. A colon. And a cervix. Three men, three women—mean age, 55; range, 34 to 70. Two other physicians, a physician's wife, my accountant of 27 years, a much-loved brother-in-law. And Kath. Katherine Swan Ginsburg, 34, MD, MPH. Department of Rheumatology, Brigham and Women's Hospital, Instructor in Medicine, Harvard Medical School, first author of an article (1) in this issue of Annals; and my youngest daughter.Kath had been away from home for 16 years—UCSD, Tulane...Reference1. GinsburgLiangNewcomerGoldhaberSchurHennekensStampfer KMLSPCM. Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. Ann Intern Med. 1992;117:997-1002. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H.J.C. Swan, MD, PhDAffiliations: 1075 Wallace Ridge Beverly Hills, CA 90210 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHarold James Charles (“Jeremy”) Swan, MD, PhDAnnals of Internal Medicine at Age 75: Reflections on the Past 25 YearsEdward J. Huth, MD and Kathleen Case, MS 15 December 1992Volume 117, Issue 12Page: 1049-1050KeywordsCervixColonHeartHospital medicineLungsRheumatology ePublished: 1 December 2008 Issue Published: 15 December 1992 Copyright & Permissions© 1992 American College of PhysiciansPDF downloadLoading ...
THE RELATIONS OF THE SEXUAL ORGANS TO THE DEVELOPMENT.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Moderated ePoster Session 6
Authors: D Mesquita, ; Abreu, ; Portugal, ; Cunha, ; Oliveira, ; Carmo, ; Santos, Santa -Clara, ; Oliveira, ; Ferreira, K Same, B Lauer, P Putzu, P Pellicori, K Hutchinson, J Cuthbert, R Dierckx, S Rimmer, Smith Zhang, A Clark, J Cleland
Journal: European Journal of Heart Failure (2014)
Abdominal Operations
Authors: Ben Eiseman
Journal: JAMA (1969)

Surgical texts, like ICBMs, are getting bigger and more complex. Because of their escalating cost, they also are becoming a shared international responsibility. Their targeting has shifted from a single precise aim to a multi-impact spread. Rodney Maingot has thus altered the object of his classic, precise text on abdominal operations. The new edition contains several warheads aimed in many directions. The fifth edition is big and expensive. Of the 82 authors, 52 are American. Proliferating targets in this edition include aneurysms, obliterative arterial disease, pulmonary embolus, and nonspecific areas such as metabolic response to trauma and selection of antibiotics. In some cases there is needless overkill, such as the duplicatory chapters by Turn-ball (new) and Ault (old) on no-touch removal of colon cancers. Format differs for each subject, as we would expect with so many contributors. A few (and they are best) make no apology for the work's being
Soil abatement and lead levels in children
Authors: T. L. Schlenker
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The study by Weitzman et al<sup>1</sup>quantifying changes in children's blood lead levels in response to three different environmental interventions used in and around their homes is a valuable contribution to a field thirsting for quantitative data. Their data, combined with data generated from intervention studies in other locales, may be well used by thoughtful people to construct a cost-benefit analysis of household lead abatement that will guide US health and housing policy in the years to come. Weitzman et al deserve credit for a well-organized and scientifically sound study that in many ways will serve as a model for others. One apparent shortcoming, however, is the lack of a "no abatement" control group. (Because the study was confined to children with low levels of lead exposure [0.34 to 1.16 μmol/L (7 to 24 μg/dL)] in which abatement is of unproven value, one would not be
PLoS Medicine Issue Image | Vol. 2(5) May 2005
Journal: PLoS Medicine (2005)

This painting was done in 1992 or 1993. It was just after I had left Rosemount psychiatry ward, which was the first time I had been in hospital. It was an eye-opener. Being in hospital was everything that you expect it to be, but then nothing like that at all. The end of the line—I had nowhere else to go. The painting itself was a tough one. Even though it looks fairly simple, to get it to that stage, the colours and shapes, was quite a chore. Every morning and night was medication time and all the patients in our ward would line up outside of a small window through which a nurse would dispense the various pills. At first I tried to paint the picture in the colours of the scene itself (a faint lemon colour)—it didn't work. I tried many different background colours for days until I thought about it—instead of painting the scene, paint what it felt like the mood of it. In this issue of PLoS Medicine, Dr. John McGrath and colleagues publish the results of a systematic review of the prevalence of schizophrenia. He and the staff of the University of Queensland Park Centre for Mental Health use paintings such as this one by Glenn Brady to teach students about the person behind the disorder. McGrath writes: Glenn's painting provides a vivid glimpse into psychiatric care early last decade. Over the last three decades, many developed countries have shifted the care of people with psychotic disorders from inpatient settings to the community. However, we still have a long way to go. Despite optimal treatment (medication, rehabilitation, and disability support), many people with schizophrenia still have persisting disability. Paintings can communicate the pain and suffering associated with serious mental illness better than textbooks. Glenns work inspires our staff to research ways to improve services for those with psychotic disorders, and also to unravel the genetic and nongenetic factors that cause schizophrenia.Image Credit: Glenn Brady (glenox [at] byrononline.net)
Need for a patient advocate
Authors: C. Moore
Journal: JAMA (1989)

GOVERNMENT and the insurance industry have intruded in recent years into the delicate, crucial relationship between physicians and patients. The primary physician's ability to play an unbiased role in the decisions about optimum care and a patient's faith in one physician's capacity to manage important health matters are disappearing.<sup>1</sup>Experts foresee no relief from this medical care muddle (<i>New York Times</i>. May 2, 1988:26).<sup>2-4</sup>When major disease strikes today, care is revealed to be patterned by quasi-medical and nonmedical forces. Optimum care becomes rationed by the size and wealth of each medical care complex.<sup>5</sup>Routine care often follows this dictum: treat at local facilities until things go badly, then refer (this can waste money and often harms patients). The patient is caught in the middle. Primary physicians working in this new milieu struggle to sustain complete commitment to patient welfare.<sup>6</sup>To survive, many primary physicians today
Being Relevant
Authors: Jessica Zitter
Journal: Annals of Internal Medicine (2019)

On Being a Doctor19 February 2019Being RelevantJessica Zitter, MD, MPHJessica Zitter, MD, MPHHighland Hospital, Oakland, California (J.Z.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-2294 Audio Reading - "Being Relevant" Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Being Relevant," by J. Zitter. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I've been transitioning from practicing mostly critical care to practicing palliative care. And I'm having a tough time.There are many possible reasons: I'm seeing more death, I'm breaking more bad news, and our new subspecialty is still finding its way in the system. But it's more than that. I often find myself feeling less essential than I am accustomed to feeling. For an ICU doctor, that can be a bitter pill to swallow.A few months ago, I was asked to do a palliative care consult on an African American woman in her mid-40s with an obstructing cancer of ... Author, Article, and Disclosure InformationAffiliations: Highland Hospital, Oakland, California (J.Z.)Corresponding Author: Jessica Zitter, MD, MPH, Highland Hospital, Department of Internal Medicine, 1411 E. 31st Street, Oakland, CA 94602; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - "Being Relevant" Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Being Relevant," by J. Zitter. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byWhy did he say that? Teaching physicians-in-training how to recognize hidden emotions in end-of-life prognosis conversations: an autoethnographyWhy did he say that? Teaching physicians-in-training how to recognize hidden emotions in end-of-life prognosis conversations: an autoethnographyWhy did he say that? Teaching physicians-in-training how to recognize hidden emotions in end-of-life prognosis conversations: an autoethnography 19 February 2019Volume 170, Issue 4Page: 269-270KeywordsAfrican American peopleEatingEmotionsHospital medicineIntensive care unitsPalliative carePatientsTouchWalkingWine ePublished: 19 February 2019 Issue Published: 19 February 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...