tbuckley/cabot-search huggingface dataset:
ON THE REPORTING OF CASES
Authors: J. R. E.
Journal: Annals of Internal Medicine (1960)

Editorials1 December 1960ON THE REPORTING OF CASESJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-6-1271 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCareful and intelligent observation of the sick patient lies at the very core of the practice of medicine. From time immemorial physicians have improved their own practice of medicine by noting carefully the manifestations of disease and have assisted their colleagues by communicating the results of their observations. Case reports published in the ANNALS OF INTERNAL MEDICINE have been for many years a valuable and stimulating source of educational material for the medical reader. The new Editor will continue this section. He invites the readers of the ANNALS to continue to submit case reports for publication.Variety of disease is... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1960Volume 53, Issue 6Page: 1271-1272KeywordsMedical education ePublished: 1 December 2008 Issue Published: 1 December 1960 PDF downloadLoading ...
Neurologic Consequences Of Cocaine Use
Authors: M. Rowbotham
Journal: Annual Review of Medicine (1990)

Neurologic consequences of cocaine use frequently present as medical emergencies in the form of stroke, repeated seizures, encephalopathy, acute headache, and unusual transient neurological deficits. The often fatal or disabling neurologic syndromes have only recently been recognized but are now well documented. Cocaine use is a significant cause of stroke in young adults, and the full, long-term ramifications of maternal cocaine use on the fetus will not be known for years to come. Unfortunately, there is not effective treatment other than abstinence, and our understanding of the pathophysiology of cocaine-associated neurologic illness remains limited.
Ultrastructural studies of hepatocyte cytoskeletons of phalloidin-treated rats by quick-freezing and deep-etching method
Authors: A Naramoto
Journal: Hepatology (1991)

We observed hepatocyte cytoskeletons in phalloidintreated rats by the quick-freezing and deep-etching method in three dimensions and compared them with the ultrastructural findings on conventional ultrathin sections. The numbers of microvilli in dilated bile canaliculi were decreased in the rats treated with phalloidin for 1 wk. In hepatocytes the cytoplasm around bile canaliculi could be divided into three layers, increased microfilament layer, cell organelle layer of secretory system and increased smooth surface endoplasmic reticulum layer. In the rats treated with phalloidin for 4 wk, microfilaments were extended into the cytoplasm near the nucleus in addition to the increased number of large lysosomes and microtubules. In both groups, three-dimensional structures of microfilaments could be visualized around bile canaliculi and along cell borders by the quick-freezing and deep-etching method. The branching microfilaments with the diameters of 7 to 10 nm were directly attached to other filaments, cell organelles or cytoplasmic sides of cell membranes. Moreover, bundled intermediate filaments were increased around peribiliary microfilaments associated with long-term cholestasis. It is suggested that excessive accumulation of peribiliary microfilaments disturb the secretion of bile components into bile canaliculi. The cytoskeletal reorganizations of intermediate filaments seem to alter the arrangements of various cell organelles. (HEPATOLOGY 1991;222–229).
HIV Infection Reporting — United States
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Michael Arthur Senior
Journal: BMJ (2011)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Michael Arthur Senior Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Changing patterns in the practice of carotid endarterectomy in a large metropolitan area
Authors: T. G. Brott
Journal: JAMA (1986)

Changes in the practice of carotid endarterectomy were studied by review of all endarterectomies performed in the greater Cincinnati area during 1980 and from July 1983 through June 1984. The number of operations rose from 431 to 750 (74% increase). The perioperative stroke rate fell from 8.6% in 1980 to 5.1% in 1983-1984; operative mortality declined from 2.8% to 2.3%; and the combined stroke or death rate declined from 9.5% to 6.5%. Asymptomatic carotid artery disease was the indication for 50% of the endarterectomies during both time periods. The combined stroke or death rate for asymptomatic patients declined from 6.9% to 5.3%, but both rates were higher than the 3% suggested as acceptable for prophylactic carotid endarterectomy. We conclude that carotid endarterectomy is becoming an increasingly common procedure, that morbidity continues to decline, and that mortality continues to be significant. Citywide surgical morbidity and mortality remain excessive for patients with asymptomatic carotid disease. (<i>JAMA</i>1986;255:2609-2612)
A phase II trial of thalidomide (T), irinotecan (I) and gemcitabine (G) in chemonaive patients (pts) with advanced non-small cell lung cancer (NSCLC)
Authors: D. B. Flora, B. Kleykamp, M. Knapp, R. Shukla, A. R. Jazieh
Journal: Journal of Clinical Oncology (2004)

7258 Background: The aim of this study was to determine the efficacy of thalidomide, an immune modulator with anti-angiogenic effects, given in combination with chemotherapy in previously untreated pts with advanced NSCLC. Methods: Pts with stage IIIB/IV NSCLC with SWOG performance status≤ 2 and adequate bone marrow, liver and renal function were treated with G (1000 mg/m2) and I (100 mg/m2) IV on days 1 and 8 of a 21 day cycle. Pts also received T at a starting daily dose of 200 mg orally. T doses were escalated by 100 mg/week as tolerated to a maximum daily dose of 400 mg. Serial levels of tumor hypoxia markers osteopontin (OPN), plasminogen activator inhibitor-1 (PAI-1) and vascular endothelial growth factor (VEGF) were measured during treatment by enzyme-linked immunosorbent assay (ELISA). Results: 11 pts have been enrolled, with 8 pts evaluable to date (1 stage IIIB with malignant pleural effusion and 7 stage IV) for disease response. Three pts experienced NCI grade III-IV toxicities requiring removal from trial, including 2 pts with thromboembolic complications, and one patient (pt) with likely therapy-related pneumonitis. Median age of pts was 56 years (41–70), male/female was 7/4. Median number of chemotherapy cycles received was 3 (1–6). Median time to progression is 4.3 months (1.4–11.9). At a median follow up of 12 months (6–15), median survival has not yet been reached, with 7/11 pts still alive. One pt achieved a partial response (12.5%) and 3 of 8 evaluable pts still have stable disease (37.5%). Trends in the serum levels of the measured serum hypoxia markers appeared to correlate with status of disease. The largest reductions in the three measured markers OPN, PAI-1 and VEGF occurred in the pt who had a partial disease response to the therapy, with decreases of 86%, 74% and 19%, respectively. Conclusions: The described regimen has activity in advanced NSCLC, and will be further evaluated with a larger number of pts and a longer follow up. Given the preliminary observations in this study, the use of the serum hypoxia markers, OPN, PAI-1 and VEGF as potential surrogates for tumor response in NSCLC merits further investigation. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Celgene; Pfizer
COPD
Authors: Terri Kirby Erickson
Journal: Annals of Internal Medicine (2016)

Ad Libitum1 November 2016COPDTerri Kirby Erickson, BATerri Kirby Erickson, BAFrom Lewisville, North Carolina.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-1839 Audio Reading - “COPD” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "COPD," by T.K. Erickson. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Listening to my father cough, struggle for breathwhen walking up a hill or climbingthe steep stairs to his bedroom, I want to lassothe air, capture it like a runaway calf and give itto him the way he used to bring homemoney. Funny that air is plentiful and free,yet he never has enough. Because my father'slungs have turned against him like a friend will,on occasion, without telling you the reason, hewheezes, gasps, and sputters like an oldsteam engine on its last lap around a lake. For myfather, I would rob a breeze-filled bank, emptyits vault of ... Author, Article, and Disclosure InformationAffiliations: From Lewisville, North Carolina.Current Author Address: Terri Kirby Erickson, BA; e-mail, [email protected]rr.com. PreviousarticleNextarticle Advertisement Audio Reading - “COPD” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "COPD," by T.K. Erickson. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 1 November 2016Volume 165, Issue 9Page: 672KeywordsClimbingLungsOxygenWalking ePublished: 1 November 2016 Issue Published: 1 November 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Substitution Permissible
Authors: Wanda W. Young
Journal: JAMA (1986)

The authors of "Clinical Overlap Among Medical Diagnosis-Related Groups"1 have described, in my opinion, several serious limitations of the diagnosis-related group (DRG) patient classification. First, understanding the clinical interrelatedness of<i>International Classification of Diseases</i>—Ninth Revision— Clinical Modification (ICD-9-CM) diagnosis codes is critical to the design of a valid patient classification from both a clinical and payment perspective. Second, and equally important, is the way those codes are used to assign patients to categories. The DRG patient classification does not address either of these issues adequately. In fact, as Drs Iezzoni and Moskowitz point out, the problem of clinical overlap is intrinsic to the DRG methodology. Although DRGs may predict hospital resources used on average (eg, average length of stay and average charges or costs of services), they do not define patient types that are clinically specific. Drs Iezzoni and Moskowitz indicate why this is true conceptually and provide examples
12. Children and Adolescents: <i>Standards of Medical Care in Diabetes—2018</i>
Journal: Diabetes Care (2017)

The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
Validation of a new prognostic model to easily predict outcome in renal cell carcinoma: the GRANT score applied to the ASSURE trial population
Authors: S. Buti, M. Puligandla, M. Bersanelli, R.S. DiPaola, J. Manola, S. Taguchi, N.B. Haas
Journal: Annals of Oncology (2018)

Ann Oncol 2017; 28: 2747–2753 (doi: 10.1093/annonc/mdx492) In the original article, the following funding information was omitted: This study was coordinated by the ECOG-ACRIN Cancer Research Group (Peter J. O'Dwyer, MD and Mitchell D. Schnall, MD, PhD, Group Co-Chairs) and supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: CA180820 and CA180794. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government. This has now been added. Validation of a new prognostic model to easily predict outcome in renal cell carcinoma: the GRANT score applied to the ASSURE trial populationAnnals of OncologyVol. 28Issue 11PreviewPrognostic scores have been developed to estimate the risk of recurrence and the probability of survival after nephrectomy for renal cell carcinoma (RCC). The use of these tools, despite being helpful to plan a customized schedule of follow-up, to the patient's tailored counselling and to select individuals who could potentially benefit from adjuvant treatment, currently is not routine, due to their relative complexity and to the lack of histological data (i.e. necrosis). Full-Text PDF Open Archive
Effect of interferon-γ on hepatitis B viral antigen expression in primary hepatocyte culture
Authors: J Lau
Journal: Hepatology (1991)

Interferon-α has been shown recently to selectively enhance hepatocyte expression of HBsAg/pre-S2 in chronic hepatitis B virus infection in a way that may enhance immune recognition. To determine the effect of interferon-γ on hepatitis B virus antigen expression, hepatocytes isolated from patients with chronic hepatitis B virus infection were incubated in the absence or presence of interferon-γ and viral antigen expression was assessed by both radioimmunoassay and immunocytochemistry using appropriate monoclonal antibodies. Interferon-γ inhibited the expression of all hepatitis B virus antigens tested. Intracellular HBsAg measured by radioimmunoassay of sonicated hepatocytes fell by 29% with 1 U/ml (p < 0.01) and 36% with 10 U/ml of interferon-γ (p < 0.001) compared with control treatment. Secreted HBsAg was reduced by 19% with 10 U/ml of interferon-γ (p < 0.01). Intracellular HBeAg was also decreased by 29% with 1 U/ml (p < 0.05) and 42% with 10 U/ml of interferon-γ (p < 0.05), but no significant change was found in the amount of secreted HBeAg. The proportion of hepatocytes containing various hepatitis B virus antigens and the intracellular viral antigen staining densities also fell significantly with interferon-γ incubation. Interestingly, the addition of interferon-γ abolished the augmenting effect of interferon-α on intracellular HBsAg. These data indicate that interferon-γ, in contrast to interferon-α, has an inhibitory effect on hepatocyte expression of all hepatitis B virus antigens including HBsAg/pre-S2, suggesting that this may be one factor that accounts for their difference in clinical activity in patients with chronic hepatitis B virus infection. (HEPATOLOGY 1991;14:975–979.)
Regulation of the biology of cholangiocarcinoma (CCA) cells by the extracellular-signal regulated kinase 5 (ERK5)
Authors: Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Elisabetta Rovida, Chiara Raggi, Giovanni Di Maira, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Fabio Marra
Journal: Journal of Hepatology (2020)
Mercury-Induced Renal Autoimmunity: Changes in RT6 + T-Lymphocytes of Susceptible and Resistant Rats
Authors: Linda L. Kosuda, Dale L. Greiner, Pierluigi E. Bigazzi
Journal: Environmental Health Perspectives (1993)

sponses and disease (1).However, stud-H usually quite difficult because the absorppresor.ce1kI,.'.'eidoyeR'nt4dnt.
An approach to the surgical treatment of pulmonary embolism
Authors: R. W. Frater
Journal: JAMA (1966)

In a series of cases of acute pulmonary embolism, the value of hemodynamic and angiographic studies as aids to diagnosis and prognosis and the planning of therapy is illustrated. In three patients hemodynamic changes indicative of a potentially fatal outcome were produced by massive embolization on one side accompanied by previous pulmonary disease or minor embolization on the other side. These changes were restored to normal by unilateral embolectomy without the aid of cardiopulmonary bypass. The possibility of using a unilateral extraction of emboli as a part of open-chest resuscitative procedures in the patient who has had sudden massive "fatal" embolism was seen in two further patients in whom this was done although without survival.
Epidemiological approach to malignant melanoma.
Journal: BMJ (1972)

the ratio of urinary uric acid to urinary creatinine; it exceeds 2.0 in the complete syndrome.Values exceeding 0.75 are found in partial expression of the abnormality25 and also in leukaemia and von Gierke's disease.The early onset of gout usually implies severe disease,5 26 27 often accompanied by the development of renal calculi, and renal impairment sometimes precedcng the signs in the joints.5It is usually associated with a positive family history, especially of severe disease, and it is worth bearing in mind the forms secondary to either haematological disorders or the rare enzyme deficiencies described above.
Urticaria pigmentosa and systemic mastocytosis
Authors: R. M. Caplan
Journal: JAMA (1965)

Urticaria pigmentosa is an uncommon skin disorder consisting of localized dermal infiltrates of tissue mast cells. Similar infiltrates at times occur in other organs, producing symptoms or signs of systemic mastocytosis. Since only occasional patients with cutaneous lesions also have visceral involvement, it is useful to recognize the major varieties of urticaria pigmentosa: (1) the solitary lesion, (2) multiple lesions of infancy or early childhood, and (3) multiple lesions appearing in later childhood, adolescence, or adulthood. Approximately one fifth of the patients in the third group may have systemic involvement.
Cardiac Resuscitation
Authors: T. H. Sellors
Journal: BMJ (1963)

<h3>Background</h3> Cross-border healthcare is complex, increasingly frequent and causes potential risks for patient safety. In this context, cross-border handovers or the transfer of patients from one country to another deserves particular attention. Although general handover has been the topic of extensive research, little is known about the challenges of handover across national borders, especially as perceived by stakeholders. In this study, we aimed to gain insight into healthcare professionals’ perspectives on cross-border handover and ways to support this. <h3>Methods</h3> We conducted semistructured interviews with healthcare professionals (physicians, nurses, paramedics and administrative staff) in a European border region to investigate their perspectives on cross-border handover. The interviews were aimed to investigate settings of acute and planned handover. Informed by the theory of planned behaviour (TPB), interviews focused on participant perspectives. We summarised all interviews and inductively identified healthcare professionals’ perspectives. We used elements of the TPB as sensitising concepts. <h3>Results</h3> Forty-three healthcare professionals participated. Although respondents had neutral to positive attitudes, they often did not know very well what was expected of them or what influence they could have on improving cross-border handover. Challenges covered five themes: <i>information transfer</i>, <i>language barriers</i>, <i>task division and education</i>, <i>policy and financial structures</i> and <i>cultural differences</i>. To overcome these challenges, we proposed strategies such as providing tools and protocols, discussing and formalising collaboration, and organising opportunities to meet and get to know each other. <h3>Conclusion</h3> Healthcare professionals involved in cross-border handovers face specific challenges. It is necessary to take measures to come to a shared understanding while paying special attention to the above-mentioned challenges. Meeting in person around meaningful activities (eg, training and case discussions) can facilitate sharing ideas and community building.