tbuckley/cabot-search huggingface dataset:
Origin of Fibroblasts in Wound Healing: An Autoradiographic Study of Inhibition of Cellular Proliferation by Local X-Irradiation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minocycline-associated tooth discoloration in young adults
Authors: S. C. Poliak
Journal: JAMA (1985)

After observing a patient with adult-onset tooth discoloration coincident with minocycline administration, we retrospectively surveyed a cohort of patients with severe cystic acne during therapeutic trials with isotretinoin. Four of 72 patients who had minocycline therapy during adolescence were found to have minocycline-associated tooth discoloration, which occurred in one case after only four weeks of treatment. Thus, minocycline must be considered as an uncommon cause of tooth staining in adults.
Abstract 2531: Reduction of <i>In Vivo</i> Tumor Growth and Angiogenesis by a Humanized IgG4 Monoclonal Antibody to SEMA4D
Authors: Alan S. Jonason, Terrence L. Fisher, Sebold Torno, Holm Bussler, Michael A. Doherty, Laurie A. Winter, Christine Reilly, Renee Kirk, Alan Howell, He Huang, Jeff Caplan, Patrick Kenney, Maria Scrivens, Tracy Pandina, Leslie Croy, Elizabeth E. Evans, Mark Paris, Raymond Watkins, Maurice Zauderer, John E. Leonard, Ernest S. Smith
Journal: Cancer Research (2012)

Abstract Semaphorin 4D (SEMA4D; CD100) has been implicated in several key mechanisms of tumor progression, including metastasis, tumor invasion, and neovascularization. SEMA4D binding to its receptor plexin-B1 (PLXNB1) on endothelial cells activates RhoA and AKT signaling pathways, which promotes formation of new blood vessels and tumor growth in vivo. SEMA4D is over-expressed in a wide array of tumor types, and is also produced by inflammatory cells recruited to the tumor microenvironment, such as tumor-associated macrophages. In addition to its effects on endothelial cells, the interaction of PLXNB1 with MET and ERBB2 can lead to SEMA4D-mediated transactivation of these membrane receptor kinases with a direct effect on tumor cell migration and invasive growth. Collectively, these results suggest that expression of SEMA4D, either by tumor cells or by tumor associated inflammatory cells, functions as a crucial factor in tumor metastatic potential, and that expression of SEMA4D and/ or its high affinity receptor in tumors induces neovascularization and increases overall tumor aggressiveness. Antibody neutralization of SEMA4D represents a new therapeutic strategy for cancer treatment. We selected a humanized IgG4 antibody, VX15/2503, that binds with roughly 3 nM affinity to rat, mouse, primate, and human SEMA4D. We utilized cellular collapse, flow cytometric and other in vitro functional assays to demonstrate that this antibody blocks SEMA4D interaction with PLXNB1. Using both this antibody and its mouse IgG1 equivalent, MAb 67-2, we have demonstrated that antibody-mediated SEMA4D neutralization blocks tumor growth in CT26 tumor grafts with a tumor growth delay (TGD) of 42% and BCA34 (TGD 18%) tumor grafts, as well as RIP-Tag2, with a tumor growth inhibition (TGI) of 56%, and Tyr:NRAS (TGD 52%) spontaneous tumor models. In summary, we demonstrate that antibody mediated neutralization of SEMA4D in vivo inhibits tumor growth and tumor angiogenesis in a variety of tumor models. The humanized antibody, VX15/2503, has successfully completed IND-enabling toxicology testing and a Phase I trial is currently being conducted in adult patients with advanced solid tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2531. doi:1538-7445.AM2012-2531
Brief Report: Latent Tuberculosis Infection Among Sailors and Civilians Aboard U.S.S. Ronald Reagan—United States, January-July 2006
Authors: R Bailey, J Saaddine
Journal: JAMA (2007)

percentage reporting no visit to an eyecare professional in the preceding 12 months ranged from 30.4% (Iowa) to 34.8% (Texas).Persons in the five states cited "no reason to go" (range: 42.8% in Louisiana to 60.9% in Iowa) and "cost/ insurance" (range: 18.5% in Ohio to 22.1% in Tennessee) as the most common reasons for not having visited an eye-care professional in the preceding 12 months.Overall, persons aged 50-59 years were least likely to report not having eye-care insurance.The percentage of persons who had not had a dilated eye examination or a visit to an eye-care professional in the preceding 12 months decreased with increasing age (pϽ0.05).Men were more likely than women to report not having had a dilated eye examination or not having had an eyecare visit.Having eye-care insurance and use of eye care also varied by race/ethnicity, education, and income (pϽ0.05).Hispanics were more likely than non-Hispanic whites to report not having eyecare insurance, not having had a dilated eye examination, and not having had an eye-care visit during the preceding 12 months.Respondents with less than a high school education or annual household income Ͻ$15,000 were least likely to use eye-care services.Moreover, the percentage without eye-care insurance decreased as education and income levels increased (pϽ0.05).
Maintaining competency in advanced cardiac life support skills
Authors: J. K. Stross
Journal: JAMA (1983)

One hundred thirty-two physicians who successfully completed advanced cardiac life support (ACLS) training were randomly placed in a control group or one of two groups receiving interventions designed to provide reinforcement of previously mastered knowledge and skills. These interventions included mailed periodic reprints (group 1) or quarterly patient management problems (group 2). All physicians were retested for knowledge and skills related to ACLS one year later. Fifty-two (39.4%) could successfully ventilate the mannequin, and 62 (47.0%) could perform cardiac compression adequately. No differences were noted among groups. Significant differences in knowledge were found. The control group initiated appropriate therapy in a mock-arrest situation 52% of the time, while group 1 averaged 75% and group 2 averaged 82%. These results indicate that reinforcement after continuing medical education may enhance knowledge retention, but does not maintain motor skills. Yearly recertification in ACLS skills should be considered, and frequent practice sessions should be encouraged for those physicians who are not active participants in ACLS activities. (<i>JAMA</i>1983;249:3339-3341)
Die Funktionsprüfung des Auges mit einem Anhang Physiologie und Pathologie der Pupille für Studierende und praktische Aerzte.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mass simulating fetal head in pelvis of a 68-year-old man
Authors: A. Rubin
Journal: JAMA (1981)

<h3>History</h3> A 68-year-old chronic alcoholic man with ascites had a strangulated umbilical hernia. Bowel palpated in the hernia sac was reduced. A paracentesis was also performed because of the marked ascites and abdominal distention. A supine anteroposterior abdominal roentgenogram (Fig 1) and horizontal beam and oblique supine abdominal films were then obtained. <h3>Diagnosis</h3> Air in an empty umbilical hernia ("pregnant male" sign). <h3>Comment</h3> The large circular rim density observed on the supine anteroposterior abdominal film was suggestive of a fetal head in the pelvis. A horizontal beam cross-table lateral film confirmed the presence of air in the umbilical hernia, which was displaced inferiorly by the massively distended abdomen (Fig 2). The air acted as a contrast to the margin of the hernial sac, which produced the unusual radiological appearance of the supine abdominal film. It is presumed that the air was introduced into the peritoneal cavity during the paracentesis and
Oncologist Lost
Authors: B. A. St Andrews
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Myeloid Leukemia and Myelodysplastic Syndromes Following Essential Thrombocythemia Treated With Hydroxyurea: High Proportion of Cases With 17p Deletion
Authors: Yvon Sterkers, Claude Preudhomme, Jean-Luc Laı̈, Jean-Loup Demory, Marie-Thérèse Caulier, Eric Wattel, Dominique Bordessoule, Francis Bauters, Pierre Fenaux
Journal: Blood (1998)
Oncology
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Human Cerebrospinal Fluid. An Investigation of the Most Recent Advances, as Reported by The Association for Research in Nervous and Mental Disease. The Proceedings of the Association
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ligue Europeenne contre le Rhumatisme: Iv Rheumatological Congress
Journal: Annals of the Rheumatic Diseases (1959)

the other appeared to perpetuate itself.The reason was not known, and that was an important field for work.The Rose-Waaler factor did not appear to have a great deal to do with it as the Rose-Waaler test had remained positive in one of his patients who had apparently completely resolved.
MEDICAL DISCOVERIES BY THE NON-MEDICAL.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Practical Nursing for Male Nurses In The R. A. M C. and Other Forces.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuel de radiodiagnostic clinique
Journal: JAMA (1934)

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Reply
Authors: Emily D. Bethea, Qiushi Chen, Chin Hur, Raymond T. Chung, Jagpreet Chhatwal
Journal: Hepatology (2018)

Potential conflict of interest: Dr. Chung received grants from Gilead, AbbVie, Merck, and Janssen. Dr. Chhatwal consults for and received grants from Merck and Gilead. Author names in bold designate shared co‐first authorship. We appreciate Congly and Lee's interest in our study evaluating the cost‐effectiveness of initiating direct‐acting antiviral (DAA) treatment for acute hepatitis C virus (HCV) infection.1 Our study sought to simulate the lifetime clinical course of patients with acute HCV. We found that treating acute HCV was cost‐effective in patients at low risk of transmitting HCV and cost‐saving in patients at high risk of transmitting HCV. We agree with Congly and Lee's contention that treatment of acute HCV will result in extra spending, but quality‐adjusted life years will be gained and new infections prevented. If the primary objective in the short term is to save money, then we should not treat acute HCV in low‐risk patients. On the other hand, if the objective is to improve health outcomes, then it is advantageous to invest in interventions that provide good value for money spent. This type of value determination can be assessed through cost‐effectiveness analyses; our results demonstrate that treating acute HCV with 6 weeks of DAA therapy is cost‐effective, even for patients at low risk of transmission. Cost‐saving benefits are observed in patients at risk of transmitting HCV, a group that is growing rapidly with the opioid epidemic.2 We acknowledge that only a small number of studies have evaluated the efficacy and duration of DAA use in acute HCV. Although this lack of data is a limitation, we believe that the robust data on the efficacy observed with DAAs in chronic HCV, and historic evidence that treatment of acute HCV results in higher cure rates with shorter duration therapy,3 will result in future studies confirming our conclusions. Congly and Lee reference the challenge of diagnosing acute HCV infection, and note that the spontaneous clearance rate (SCR) in symptomatic patients may be higher than the 28% used in our base‐case analysis. We performed sensitivity analysis on SCRs, and demonstrated that acute HCV treatment for patients at risk of transmitting HCV is cost‐saving up to SCRs of 35% and cost‐effective at rates close to 50%. Importantly, the majority of patients with acute HCV are asymptomatic and experience SCRs much lower than 50%4; targeted identification and treatment of this population will have the greatest impact on health outcomes. If future studies continue to show high acute HCV cure rates with shorter treatment durations, then treatment of patients with acute HCV infection will be a strategy worth pursuing, given that it can improve clinical outcomes and be highly cost‐effective or cost‐saving compared with deferring treatment to the chronic phase.
A Simple Injector for Lymphangiography
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Torsades de pointes occurring in association with terfenadine use
Authors: D. R. Mathews
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Monahan et al<sup>1</sup>reported a case of torsades de pointes after concomitant administration of terfenadine (Seldane) and ketoconazole (Nizoral). We would like to comment on this report and share results from subsequent studies at Marion Merrell Dow Inc, Kansas City, Mo. Terfenadine normally undergoes extensive (99%) first-pass metabolism to two metabolites: an active acid metabolite and an inactive dealkylated metabolite. Therefore, unchanged terfenadine is normally undetectable (ie, &lt;10 ng/mL) in plasma. However, in cases of hepatic impairment or when certain concurrent medications (eg, ketoconazole) inhibit the metabolism of terfenadine, unchanged terfenadine can become detectable in plasma while metabolite formation is decreased. In cases of terfenadine overdose, unchanged terfenadine can become detectable and acid metabolite levels increase.<sup>2</sup> In a study of 24 subjects given a single 60-mg dose of terfenadine, the mean peak plasma acid metabolite level was 263 ng/mL and occurred 2.5 hours after dosing.