tbuckley/cabot-search huggingface dataset:
Infantile Eczema: Evidence of Autoimmunity to Human Skin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insurance Fees and Lodge Practice
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents: (Adv. Healthcare Mater. 23/2016)
Journal: Advanced Healthcare Materials (2016)

Cancer Cell InvasionFilomena Gioiella and co-workers develop a microfluidic platform hosting 3D engineered microtissues to study in vitro the tumor/extracellular matrix (ECM) interactions in the human breast cancer on page 3074.The system provides monitoring in situ stromal activation occurring during cancer cells invasion: cell activation, cell migration, ECM modification, and the variations of transport properties of the tumor stroma.
Evaluation of a broad-spectrum anthelmintic thiabendazole (Mintezol)
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neural Circuitry Engaged During Unsuccessful Motor Inhibition in Pediatric Bipolar Disorder
Authors: Ellen Leibenluft
Journal: American Journal of Psychiatry (2007)

Objective: Deficits in motor inhibition may contribute to impulsivity and irritability in children with bipolar disorder. Studies of the neural circuitry engaged during failed motor inhibition in pediatric bipolar disorder may increase our understanding of the pathophysiology of the illness. The authors tested the hypothesis that children with bipolar disorder and comparison subjects would differ in ventral prefrontal cortex, striatal, and anterior cingulate activation during unsuccessful motor inhibition. They also compared activation in medicated versus unmedicated children with bipolar disorder and in children with bipolar disorder and attention deficit hyperactivity disorder (ADHD) versus those with bipolar disorder without ADHD. Method: The authors conducted an event-related functional magnetic resonance imaging study comparing neural activation in children with bipolar disorder and healthy comparison subjects while they performed a motor inhibition task. The study group included 26 children with bipolar disorder (13 unmedicated and 15 with ADHD) and 17 comparison subjects matched by age, gender, and IQ. Results: On failed inhibitory trials, comparison subjects showed greater bilateral striatal and right ventral prefrontal cortex activation than did patients. These deficits were present in unmedicated patients, but the role of ADHD in mediating them was unclear. Conclusions: In relation to comparison subjects, children with bipolar disorder may have deficits in their ability to engage striatal structures and the right ventral prefrontal cortex during unsuccessful inhibition. Further research should ascertain the contribution of ADHD to these deficits and the role that such deficits may play in the emotional and behavioral dysregulation characteristic of bipolar disorder.
Highlights
Journal: JAMA Neurology (2019)

Statin Use and Risk of Dementia After a Concussion 887Concussions affect more than 1 million Americans each year but are sometimes dismissed in medical care if the patient recovers quickly.Redelmeier and coauthors conducted a population-based double cohort study including 28 815 patients 66 years and older who were free of dementia and diagnosed as having a concussion, with a mean follow-up of 3.9 years.Their results suggest the average concussion doubles the relative risk of subsequent dementia.The study also highlights a potential modest benefit from statins for neurological recovery and the importance of preventing concussions at all ages.Editorial perspective is provided by Whitmer.
Phase 1 dose-escalation study of ACT001 in patients with recurrent glioblastoma and other advanced solid tumors.
Authors: Jason D. Lickliter, Ross Jennens, Charlotte Rose Lemech, Steven Yung-Chang Su, Yue Chen
Journal: Journal of Clinical Oncology (2018)

e14048 Background: ACT001 is an orally-available parthenolide derivative which inhibits NF-κB signaling, has immunomodulatory effects and showed promising activity in preclinical models of glioblastoma (GBM). We performed a first-in-human clinical trial of ACT001 in patients with advanced solid tumors, including GBM. Methods: Eligible patients were ≥ 18 yrs and ECOG PS 0-1, with satisfactory hematologic, renal and hepatic function. GBM patients additionally had progressive disease (PD) despite initial radiation and temozolomide, measurable tumor, no radiation in the prior 3 months and no previous treatment with anti-VEGF drugs. ACT001 was given orally BID until intolerance or PD, and dose escalation followed a standard 3+3 design. Gliomas were imaged with MRI every 8 weeks and responses assessed using RANO criteria. Results: A total of 13 patients were enrolled: 10 with GBM, 2 with anaplastic glioma and 1 with pleural mesothelioma. Median age was 53 yrs (range, 34-72). ACT001 dose levels were 100 mg BID, 200 mg BID, 400 mg BID and 600 mg BID. Study treatment was well tolerated and no dose-limiting toxicities have occurred. Of 12 evaluable patients, best responses were a partial response in 1 GBM patient (ongoing after 10+ months of treatment), stable disease in 3 patients and PD in 8 patients. ACT001 plasma half life was 3-4 hours and no accumulation was observed after multiple dosing. At ≥ 400 mg BID, drug concentrations expected to have biological activity were reached. Conclusions: At well-tolerated doses, ACT001 showed satisfactory bioavailability and preliminary evidence of anti-tumor activity in a subset of patients. Clinical trial information: ACTRN12616000228482.
Index to volume 60
Authors: O Clemmensen, Abst Cockcroft, E Coeugniet, T Creer, See Miklich, A Crowle, M Cuff, See Cockcrow, D Cugell, D Dahlem, P Danker-Brown, A Dannaeus, Abst Johansson, Abst David, R Davies, C O'neil, Abst Davis, G Delespess, Abst Deuschl, Abst Dill, E Ellis, See Sanders, F Fawcet, See Sheffer, M Fellner, Abst Felsburg, Abst Femi-Pearse, Abst Findlay, J Fink, See Schatz, T Fischer, See Borut, J Fish, See Miller, A Fisher, D Flaherty, See Marx, N Flod, See Galant, P Ford, G Gabourel, Abst Galant, C Gillman, Abst Garra, B Shapiro, R Geha, M Geller, See Flaherty, See Findlay, S Gillman, See Kozak, N Gilmore, See Boucher, G Gleich, G Jacob, D Graham, G Granger, C Groncy, S Gupta, M Grieco, Abst Hanson, See Vaz, C Harper, H Hedin, J Ring, See Gleich, M Hetzel, Abst Hill, M Hooton, See Karpas, D Horton, See Dahlem, G Hunninglake, See Okazaki, J Jacob
Journal: Journal of Allergy and Clinical Immunology (1977)
Developing and Rewarding Good Teachers
Authors: Harley S. Schultz
Journal: Annals of Internal Medicine (1994)

Letters15 March 1994Developing and Rewarding Good TeachersHarley S. Schultz, MDHarley S. Schultz, MDSan Leonardo, CA 94578Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-6-199403150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The article on the attractiveness of internal medicine [1] evoked many memories, not all of them fond, of my internal medicine training. Regrettably, after 20 years medical students still feel “humiliated” by “malignant attendings” and “journal jockeys.” They also believe that internal medicine prolongs suffering and dying. I distinctly recall one of my fellow interns wondering why he found internal medicine so interesting and fascinating in the journals but so depressing in real hospital work.McMurray and colleagues do a service by forcing us to re-examine long-standing practices. However, I do not agree that their findings represent ...REFERENCE1. McMurray J, Schwartz M, Genero N, Linzer M. The attractiveness of internal medicine: a qualitative analysis of the experiences of female and male medical students. Ann Intern Med. 1993; 119:812-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Harley S. Schultz, MDAffiliations: San Leonardo, CA 94578 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWhat influences career choices among graduates of a primary care training program? 15 March 1994Volume 120, Issue 6Page: 526KeywordsBirthHospital medicineMemoryOutpatientsPatients ePublished: 15 August 2000 Issue Published: 15 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Considerations and Uses of Hyperbaric Oxygen Therapy in Surgery
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nicotine gum may aid weaning process
Authors: E. R. Gonzalez
Journal: JAMA (1980)

United States smokers who want to go cold turkey may, like their counterparts in Europe and Canada, someday be able to obtain prescriptions for nicotine chewing gum from their physicians. But the gum may be helpful only to certain smokers, and its role in facilitating cigarette withdrawal may be less straightforward than that of simple nicotine replacement. The gum, manufactured by AB Leo, Helsingborg, Sweden, and distributed by Dow Chemical Company, will soon undergo clinical tests by UCLA's Murray E. Jarvik, MD, PhD, and Nina G. Schneider, PhD, under a four-year, $138,000 grant from the National Institute of Drug Abuse. Previous research has shown that the gum produces variable blood nicotine levels only roughly comparable with those obtained when smoking and that the satisfaction it affords a particular chewer seems unrelated to his plasma nicotine level. Because the gum can produce plasma nicotine levels several times greater than those produced
Notice of Retraction
Journal: Circulation Research (2012)

The authors of the following article have requested that it be retracted from publication in Circulation Research: Kawakami A, Osaka M, Aikawa M, Uematsu S, Akira S, Libby P, Shimokado K, Sacks FM,Yoshida M. Toll-like receptor 2 mediates apolipoprotein CIII–induced monocyte activation.Circ Res. 2008;103:1402–1409.
???Increased Blood Flow on Radionuclide Cerebral Flow Studies in Subdural Hematoma???
Authors: Aslam Siddiqui, U Yun Ryo, Ha Yong Yum, Steven Pinsky
Journal: Clinical Nuclear Medicine (1978)

Siddiqui, Aslam M.D.; Ryo, U Yun M.D. Ph.D; Yum, Ha Yong M.D.; Pinsky, Steven M.D. Author Information
Prognostic Impact of Chromosomal Abnormalities In Elderly Patients with Multiple Myeloma Treated with High-Dose Melphalan (MEL140) and Autologous Stem Cell Transplantation
Authors: Peter Liebisch, Christian Straka, Hermann Einsele, Axel Hinke, Andreas Sandermann, Hartmut Dohner, Christian Langer
Journal: Blood (2010)
Congenital syphilis and necrotizing funisitis
Authors: K. Benirschke
Journal: JAMA (1989)

<h3>To the Editors. —</h3> Fojaco and colleagues<sup>1</sup>suggested that finding a "barber-pole" umbilical cord permits the presumptive diagnosis of congenital syphilis. Other placental pathologists disagree. The diagnosis of congenital syphilis was based on undefined criteria of results of autopsies of infants and serological results that are not accepted as absolute diagnostic criteria.<sup>2</sup>The authors found necrotizing funisitis in 46% of cases of congenital syphilis. This agrees with the findings of previous investigations. It is surprising that no necrotizing funisitis caused by other infections was found. The placental histopathology is not described. How many cases had features of syphilis? The investigators failed to specify tests that excluded other pathogens. Necrotizing funisitis is unmistakable and has been reported for decades. We see many cases, always have maternal VDRL tests done, and usually perform autopsies. Syphilis is increasing in our center also. While we find necrotizing funisitis in some cases, many
Gynecologic Pathology
Authors: Robert E. Scully
Journal: JAMA (1967)

This initial venture into textbook writing by a pathologist from the Washington University School of Medicine is an eminent success. In addition to chapters on each of the female organs, there are others on "Embryology: Genesis and Dysgenesis of the Female Genital Tract," "Extragenital Lesions of the Female Pelvis," and "The Placenta." The format of the book is pleasing, and the subject matter is well organized and lucidly presented with an emphasis on clinicopathological correlation. Unusual lesions are discussed briefly and often illustrated. The extensive bibliography has been judiciously selected and includes articles published in 1966. A valuable feature of the volume is its excellent illustrations, many of which are magnificent. They include a small number of electron micrographs, which exemplify the beginning contributions of this discipline to gynecologic pathology. One has to search for any misleading statements or omissions. The author says that a large follicle cyst is the
Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection
Authors: G Marinos
Journal: Hepatology (1996)

Interferon alfa (IFN-α) treatment is effective in only a proportion of patients with chronic hepatitis B virus (HBV) infection. The mechanisms for therapeutic failure remain unknown but high levels of HBV replication are known to inhibit the immunopotentiating effects of IFN-α. In nine patients with chronic hepatitis B not responding to IFN-α monotherapy, we determined the virus-specific T-helper-cell responses during two consecutive therapeutic regimens: IFN-α alone and IFN-α in combination with a new potent inhibitor of HBV replication, lamivudine. By comparing the results obtained during the initial IFN-α monotherapy to those during the combination treatment, it was investigated whether complete inhibition of virus replication will enhance the interferon-induced immunoreactivity to HBV. Despite the rapid reduction to undetectable serum HBV DNA in all nine patients during the combination treatment, none sustained permanent hepatitis B e antigen (HBeAg) clearance during subsequent 12-month follow-up. HLA class II-restricted T-helper-cell responses to hepatitis B core antigen (HBcAg) showed no difference during IFN-α monotherapy and during the combination of lamivudine plus IFN-α. In contrast, a delayed T-cell activation occurred after a rebound in serum HBV DNA postcombination treatment, which lead to increased hepatocytolysis. These findings suggest that the profound inhibition of HBV replication by a nucleoside analogue does not restore the impaired virus-specific T-cell response in chronic HBV infection.
IS IT ETHICAL FOR MEDICAL MEN TO PATENT MEDICAL INVENTIONS?
Authors: BY F. E. STEWART
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New visceral transplants invigorate cancer victims
Authors: M. F. Goldsmith
Journal: JAMA (1989)

TRANSPLANTATION of multiple organs into the abdomen has taken off in a new direction since the failure of the experimental operations on children described in this issue ofThe Journal. Last month, Thomas E. Starzl, MD, PhD, Department of Surgery, University of Pittsburgh (Pa) Health Center, announced that since June, 13 adults near death from hepatic, pancreatic, or duodenal carcinoma have traded their diseased organs for a chance at life via the "organ cluster" transplant procedure he is pioneering. In mid-February, 11 patients were surviving and were apparently free of cancer. All the operations were performed at Pittsburgh's Presbyterian-University Hospital. All but the most recent patient had returned home after receiving a new liver, pancreas, and duodenum. According to Saturo Todo, MD, the surgeon who led the team for many of the procedures, the liver, pancreas, duodenum, stomach, spleen, and right and transverse colon are resected. The superior mesentery artery
Cliniques dermatologiques. Deuxième série.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal