tbuckley/cabot-search huggingface dataset:
The Informationist
Authors: Stephen Sandroni
Journal: Annals of Internal Medicine (2001)

Letters6 February 2001The InformationistStephen Sandroni, MDStephen Sandroni, MDSt. Mary's Hospital; Waterbury, CT 06706 (Sandroni)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I agree with Davidoff and Florance (1) that the medical profession can and should do more to link the literature to the point of care, but I am not as pessimistic as the authors about physician capabilities in this regard. Twenty years ago, a computer literature search at a major medical school library required the help of a librarian and approximately 48 hours before a printout of potentially useful abstract titles appeared. Access to selected articles would take another day or two. Today, in a busy clinical setting, it is possible to access clinically useful information (which ...Reference1. Davidoff F, Florance V. The informationist: a new health profession? [Editorial]. Ann Intern Med. 2000;132:996-8. LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Stephen Sandroni, MDAffiliations: St. Mary's Hospital; Waterbury, CT 06706 (Sandroni) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Informationist: A New Health Profession? Frank Davidoff and Valerie Florance The Informationist Bruce Houghton and Eugene C. Rich The Informationist Michael J. Schott The Informationist Frank Davidoff and Valerie Florance The Informationist Deborah B. Root Jorgensen Metrics Cited byExploring New Roles for LibrariansWorking towards the informationistLibrarians, Surgeons, and Knowledge 6 February 2001Volume 134, Issue 3 Page: 251 Keywords Computers Libraries ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Bed, Heat, Flats, Corset for Low Back Pain
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Symposium on Biological Response Modifiers in Cancer Therapy
Journal: JNCI Journal of the National Cancer Institute (1986)

Symposium on Biological Response Modifiers in Cancer Therapy Get access JNCI: Journal of the National Cancer Institute, Volume 77, Issue 3, September 1986, Page 835, https://doi.org/10.1093/jnci/77.3.835-d Published: 01 September 1986
COMPARATIVE FREQUENCY OF DISEASES HERE AND ABROAD.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chlamydia trachomatis infection in adults with community-acquired pneumonia
Authors: A. L. Komaroff
Journal: JAMA (1981)

We studied 52 adult patients admitted to the hospital over an 11-month period with symptoms suggesting pulmonary infection. Twenty-nine had pneumonia and none were receiving immunosuppressive drug therapy. We found definite serological evidence of recent chlamydial infection in 21% (4/19) of patients with pneumonia of unclear etiology, and in 0% (0/33) of patients with other pulmonary conditions. An additional three patients with pneumonia had suggestive serological evidence of recent chlamydial infection. None of the seven patients had culture evidence of bacterial infection, or serological evidence of mycoplasmal, viral, or<i>Legionella</i>infection; none had physical examination findings suggesting intercurrent chlamydial infection of the eye or genitourinary tract.<i>Chlamydia trachomatis</i>may have been a cause of community-acquired pneumonia in some of these patients. (<i>JAMA</i>1981;245:1319-1322)
The audiovisual interview. A new tool in medical education
Authors: J. E. Verby
Journal: JAMA (1976)

The audiovisual interview with a patient in the office of the student physician or physician is an essential undergraduate, graduate, and postgraduate educational management tool. Immediate feedback and insight are obtained as to how the patient and educator perceive the performance and service of the student or professional. Therapeutic failures may be recognized, and misconceptions and misreading of verbal and nonverbal communications can be corrected immediately. There is access to integrating psychosocial and biologic variables, with a better chance to extract more valid information for creative problem-solving and less of a chance for therapeutic failures. The student recognizes and appreciates the therapy and healing in the dialogue. (<i>JAMA</i>236:2413-2414, 1976)
Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism, ,
Authors: A Casini, M Cunningham, M Rojkind, C S Lieber
Journal: Hepatology (1991)

We previously reported that acetaldehyde increases the production of type I collagen in cultured rat fat-storing cells. We studied the regulation of this effect by determining the expression of procollagen type I, fibronectin and transforming growth factor-beta 1 messenger RNAs in passage 1 and 2 cultures of fat-storing cells exposed to acetaldehyde for up to 24 hr. By 6 hr, acetaldehyde increased the steady-state levels of alpha 1 procollagen type I messenger RNA 3.2-fold and of fibronectin messenger RNA 2.8-fold above control values. At 24 hr, messenger RNA levels remained elevated. In contrast, transforming growth factor-beta 1 messenger RNA steady-state levels remained unaltered by 6 hr, but increased 1.5-fold by 24 hr. Cycloheximide (0.3 mmol/L) completely inhibited the acetaldehyde effect when added at zero time but was less effective when added at 15 min. The effect of acetaldehyde was not modified when cells were cultured in the presence of the acetaldehyde dehydrogenase inhibitor cyanamide (100 mumol/L). Fat-storing cells were also cultured in the presence of lactate (5, 15 and 25 mmol/L) for 6 hr. At none of these concentrations was any effect seen on either alpha 1(I) procollagen or fibronectin messenger RNAs. In the presence of methylene blue, a scavenger of reducing equivalents, the effect of acetaldehyde on alpha 1(I) procollagen and fibronectin gene expression was totally inhibited. Transcription run-on assay showed that acetaldehyde increased both procollagen type I and fibronectin transcriptional activity threefold and 2.5-fold, respectively. We conclude that acetaldehyde increases alpha 1(I) procollagen and fibronectin gene expression through enhanced transcription by a mechanism dependent on newly synthesized proteins.(ABSTRACT TRUNCATED AT 250 WORDS)
THE CULTIVATION OF TISSUE CELLS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis
Authors: Franck Oury, Mathieu Ferron, Wang Huizhen, Cyrille Confavreux, Lin Xu, Julie Lacombe, Prashanth Srinivas, Alexandre Chamouni, Francesca Lugani, Herve Lejeune, T. Rajendra Kumar, Ingrid Plotton, Gerard Karsenty
Journal: Journal of Clinical Investigation (2015)
John Hughes Bennett (1812-1875) Clinical Teacher of Edinburgh
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allied health education
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circumflex Masquerade
Authors: JACLYN CALEM-GRUNAT, DAVID SKLAR, JAVIER VILLANUEVA-MEYER, ISMAEL MENA
Journal: Clinical Nuclear Medicine (1992)

A 62-year-old man with a history of hypertension, borderline hypercholesterolemia, and unstable angina underwent a cardiac catheterization that revealed a 100% occlusion of the left anterior descending artery with poor distal filling. The left circumflex was an abnormal appearing large vessel, and the distal branch demonstrated a 100% proximal occlusion. The right coronary artery was totally occluded, and the posterior descending artery filled from left to right via collateral flow. The patient experienced several bleeding complications from intravenous heparin and was transferred to our institution for urgent revascularization. Coronary artery bypass graft times four was performed and included reverse saphenous vein graft to the LAD, first diagonal branch, distal left circumflex, and PDA. Approximately 22 months later, the patient began experiencing a burning sensation in the anterior part of the neck after riding a bicycle for 1 mile. Stress Tc-99m MIBI was requested, and the patient stressed via the standard Bruce Protocol. Acquisition was performed in a 180° rotation from 45° RPO to 45° LAO. SPECT images at rest revealed a septal infarct and good perfusion to the remaining myocardium. Given the patient's known situs inversus, the extensive infarction, apparently within the lateral wall, corresponds to the interventricular septum in this complete dextrocardia. For the clinician unaware of this anatomic variant, the LAD territory would be misconstrued as left circumflex pathology.
Prenatal Chromosomal Diagnosis
Authors: David C. Sokal
Journal: JAMA (1980)

In a study of Georgia women aged 40 years and older, 15% made use of prenatal chromosomal diagnosis. There was, however, substantial racial and geographic variation, ranging from a use ratio of 60% among whites in two large urban counties to 0.5% among blacks outside Augusta and Atlanta health districts. This simple population-based epidemiologic analysis suggests that future program planning for genetic services in Georgia should address ways to increase access by rural women, especially blacks. Similar analyses in other states could be used for planning genetic services. (<i>JAMA</i>244:1355-1357, 1980)
Secretory Otitis Media: The Cantekin Affair
Authors: John L. Wilson
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I appreciate the study by Cantekin et al<sup>1</sup>confirming what many of us in primary care have observed: namely, that chronic and recurrent otitis media does not respond to antibiotics. The liberal and sometimes indiscriminate use of antibiotics that are frequently prescribed by physicians can lead to, among many other problems, the often unrecognized but common condition of intestinal microbial dysbiosis and the many symptoms associated with this.<sup>2,3</sup> This article should encourage us to be more open to understanding the cause of this condition. In 1983, Green<sup>4</sup>outlined the relationship between diet and otitis media. In 1975, Viscomi<sup>5</sup>discussed the relationship between environmental influences, particularly diet, and eustachian tube dysfunction leading to middle-ear effusions and subsequent otitis. Two important articles appeared in 1990 that emphasized this relationship between otitis media and environmental factors. Hurst<sup>6</sup>published a study of 20 patients with long-term
StatBite Drug Shortages, 2001-2010
Journal: JNCI Journal of the National Cancer Institute (2011)

Drug shortages are not new, but they have increased sharply since 2006 and have affected some cancer drugs, such as ascytarabine and cisplatin.The reasons, according to the U.S. Food and Drug Administration, include manufacturing problems as well as drug company decisions to stop producing a drug that is not profitable enough.(See accompanying news story.)
Medical management of the patient with unstable angina
Authors: G. D. Plotnick
Journal: JAMA (1978)

SINCE 1937, a clinical syndrome intermediate between stable angina pectoris and classic myocardial infarction has been recognized.<sup>1</sup>This syndrome has been called a variety of names. Terms such as "preinfarction angina" or "impending myocardial infarction" unfortunately carry prognostic implications that may lead cardiologists and surgeons to precipitate action that may not be warranted. Other terms that have been used include "intermediate coronary syndrome," "accelerated angina," "crescendo angina," and "unstable angina." "Unstable angina" is the preferred term.<sup>2</sup> Unstable angina is not an isolated entity but is part of the clinical spectrum of ischemic heart disease. The vast majority of patients have extensive obstructive coronary artery disease similar to that found in patients with stable angina. Of 100 consecutive patients with unstable angina who were hospitalized in The Johns Hopkins Hospital coronary care unit and underwent arteriography, 94% had greater than 70% narrowing of at least one major coronary artery.
Stat Bite: State Tobacco Legislation, Part 2
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Stat Bite: State Tobacco Legislation, Part 2 Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 10, 17 May 1995, Page 709, https://doi.org/10.1093/jnci/87.10.709 Published: 17 May 1995
PARIS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Financial strain has a major impact on mental health
Journal: BMJ (1998)

Recovery is quicker after laparoscopic hernia repair-but there is a cost Repair of inguinal hernias is one of the most common surgical procedures.Surgeons are increasingly using a preformed synthetic mesh to cover the inguinal defect.On p 103 Wellwood et al evaluate the costs and outcomes (both clinical and patient based) of open and laparoscopic mesh repair in a randomised controlled trial of 400 patients.Patients undergoing laparoscopic hernia repair recovered faster and experienced less pain than patients who underwent standard open mesh repair.The laparoscopic procedure, however, was more costly.
The World's Almanac and Encyclopedia, 1898.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic and Environmental Factors Associated with Variation of Human Xenobiotic Glucuronidation and Sulfation
Authors: Brian Burchell, Michael W. H. Coughtrie
Journal: Environmental Health Perspectives (1997)

Glucuronidation and sulfation are phase 2 metabolic reactions catalyzed by large families of different isoenzymes in man.The textbook view that glucuronidation and sulfation lead to the production of harmless conjugates for simple excretion is not valid.Biologically active and toxic sulfates and glucuronides are produced and lead to adverse drug reactions, including immune hypersensitivity.Considerable variation in xenobiotic conjugation is observed as a result of altered expression of UDP-glucuronosyltransferases (UGTs) and sulfotransferases (STs).Recent cloning and expression of human cDNA encoding UGTs and STs has facilitated characterization of isoform substrate specificity, which has been further validated using specific antibodies and human tissue fractions.The availability of cloned/expressed human enzymes and specific antibodies has enabled the investigation of xenobiotic induction and metabolic disruption leading to adverse responses.Genetic polymorphisms of glucuronidation and sulfation are known to exist although the characterization and assessment of the importance of these variations are hampered by appropriate ethical studies in man with suitable safe model compounds.Genetic analysis has allowed molecular identification of defects in well-known hyperbilirubinemias.However, full characterization of the specific functional roles of human UGTs and STs requires rigorous kinetic and molecular analyses of the role of each enzyme in vivo through the use of specific antibodies and inhibitors.This will lead to the better prediction of variation of xenobiotic glucuronidation and sulfation in man.