tbuckley/cabot-search huggingface dataset:
Verily, Verily.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systemic giant-cell arteritis with polymyalgia rheumatica, reversible abnormalities of liver function
Authors: E. R. Dickson
Journal: JAMA (1973)

Nine patients with polymyalgia rheumatica and biopsy-proved, systemic, giant-cell arteritis had significant abnormalities of liver function. The abnormalities were reversible with steroid suppression of the arteritis activity. Awareness of this association should enable the clinician to recognize and diagnose this condition and to facilitate prompt and appropriate treatment of the underlying arteritis.
Immunopathogenesis and therapy of cutaneous T cell lymphoma
Authors: E. J. Kim
Journal: Journal of Clinical Investigation (2005)

Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative disorders caused by clonally derived, skin-invasive T cells. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common types of CTCLs and are characterized by malignant CD4+/CLA+/CCR4+ T cells that also lack the usual T cell surface markers CD7 and/or CD26. As MF/SS advances, the clonal dominance of the malignant cells results in the expression of predominantly Th2 cytokines, progressive immune dysregulation in patients, and further tumor cell growth. This review summarizes recent insights into the pathogenesis and immunobiology of MF/SS and how these have shaped current therapeutic approaches, in particular the growing emphasis on enhancement of host antitumor immune responses as the key to successful therapy.
Early Diastole
Authors: Arthur C. Fox
Journal: Annals of Internal Medicine (1986)

Ad Libitum1 January 1986Early DiastoleArthur C. Fox, M.D.Arthur C. Fox, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-138_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA and P two split their sprint,Aortics blow or Austin Flint,Mitrals snap and rumble.Failing walls distend in gallops,Restrictive sacs knock back with wallops,Tumours plop and tumble.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Arthur C. Fox, M.D.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1986Volume 104, Issue 1 Page: 138-138 Keywords Diastole ePublished: 1 December 2008 Issue Published: 1 January 1986 PDF downloadLoading ...
Spoils of Wild Game Hunt: Trichinellosis Cases in Illinois
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized phase II trial of gemcitabine plus S-1 combination therapy versus S-1 in advanced biliary tract cancer: Results of the Japan Clinical Oncology Group study (JCOG0805).
Authors: Chigusa Morizane, Takuji Okusaka, Junki Mizusawa, Atsuo Takashima, Makoto Ueno, Masafumi Ikeda, Yasuo Hamamoto, Hiroshi Ishii, Narikazu Boku, Junji Furuse
Journal: Journal of Clinical Oncology (2012)

255 Background: Gemcitabine plus cisplatin combination (GC) therapy is the standard therapy for advanced biliary tract cancer (BTC). In previous trials, gemcitabine plus S-1 combination (GS) therapy and S-1 mono-therapy had shown considerable efficacy in patients with BTC. The aim of this trial is to evaluate the efficacy and safety of the two regimens and to determine which is more promising as a test arm regimen for a subsequent phase III trial. Methods: Chemotherapy-naive patients with recurrent or unresectable BTC (gallbladder [GB], intrahepatic biliary duct [IHBD], extrahepatic biliary duct [EHBD], ampulla of Vater [AV]), an ECOG PS of 0 - 1, and adequate organ function were randomly assigned to receive GS (gemcitabine: 1000 mg/m 2 , iv, days 1 and 8; S-1: 60 mg/m 2 , p.o., days 1 - 14, every 3 weeks) or S-1 (80 mg/m 2 , p.o., days 1 - 28, every 6 weeks). We assumed that %1-year survival of one regimen is 30% and that of the other regimen is more than 40%. To ensure at least 85% probability of correct selection, 98 eligible pts are required. The decision rule was that the regimen with higher %1-year survival will be considered as more promising regimen. Results: From February 2009 to April 2010, 101 pts (GB, n=38; IHBD, n=35; EHBD, n=20; AV, n=8) were randomized (GS, n=51; S-1, n=50). For the GS arm and S-1 arm, %1-year survivals were 52.9% and 40.0%, the median survival time were 12.5 and 9.0 months (hazard ratio 0.86 [95%CI 0.54-1.36]; p=0.52), and the median progression-free survival time were 7.1 and 4.2 months (0.44 [0.29-0.67]; p&lt;0.0001). Grade 3/4 hematological toxicities were more frequent in the GS arm than in the S-1 arm, (percentage in GS/S-1 arms): neutropenia, 60.8/4.0; leukocytopenia, 29.4/2.0; hemoglobin, 11.8/4.0; and thrombocytopenia, 11.8/4.0; respectively. Although two treatment-related deaths occurred in the GS arm (pneumonitis, acute myocardial infarction), other grade 3/4 non-hematological toxicities were infrequent and reversible in both arms. Conclusions: The GS arm was superior in %1-year survival to S-1. Here we consider GS to be more promising as the test arm for a subsequent phase III trial comparing with GC.
Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome
Authors: Siegfried Ussar, Nicholas W. Griffin, Olivier Bezy, Shiho Fujisaka, Sara Vienberg, Samir Softic, Luxue Deng, Lynn Bry, Jeffrey I. Gordon, C. Ronald Kahn
Journal: Cell Metabolism (2016)
B. Medical Schools in Canada
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enzymes in intestinal strangulation-obstruction
Authors: J. A. Dixon
Journal: JAMA (1967)

<h3>To the Editor:—</h3> We would like to make a comment on the recent decision made by the Food and Drug Administration to allow further clinical evaluation of dimethyl sulfoxide in the conditions scleroderma, persistent herpes zoster, and severe rheumatoid arthritis (<i>FDA News</i>Release, Dec 22, 1966). The FDA has laid down strict guidelines for the use of this substance in patients suffering from these conditions and has also mentioned the fact that dimethyl sulfoxide may be toxic to embryos. We feel, however, that the potential effect of dimethyl sulfoxide as a teratogen should be reemphasized and kept specifically in mind by investigators about to embark on studies involving this agent. In a letter to the editor in<i>Lancet</i>(<b>1</b>:208, 1966), Dr. Vergil H. Ferm gave evidence that dimethyl sulfoxide was responsible for the development of anencephaly in golden hamster fetuses when the substance had been administered to the pregnant
Regulation of Hematopoiesis In Vitro and In Vivo by Invariant NKT Cells.
Authors: Ioannis Kotsianidis, Jonathan D. Silk, Scott Patterson, Antonio Almeida, Costas Tsatalas, George Bourikas, Vincenzo Cerundolo, Irene A.G. Roberts, Anastasios Karadimitris
Journal: Blood (2005)
Power Considerations in Studies of Reproductive Effects of Vinyl Chloride and Some Structural Analogs
Authors: Maureen Hatch, Jennie Kline, Zena Stein
Journal: Environmental Health Perspectives (1981)

We review the evidence examining the relation of reproductive function and exposure to vinyl chloride and selected structural analogs. Investigation of these compounds for possible reproductive effects has focused on paternal exposure, a much less well studied route than maternal exposure. Drawing on animal models, we discuss what is known about the possible reproductive consequences of exposure to the father as well as to the mother. In evaluating the studies of reproductive outcome in relation to vinyl chloride or analogs, we consider what biologic model may have been tested and whether there was statistical power to detect moderate increases in risk. Parameters influencing statistical power are reviewed, and recommended sample sizes are set out which would insure sufficient power, in future studies, to detect adverse effects.
CONVENTION PROGRAM
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Executive Vice-President's address
Authors: F. J. Blasingame
Journal: JAMA (1965)

I appreciate the privilege of speaking to the House, and I do so on behalf of the staff. I am grateful for the assistance I have received from staff in the preparation of this report. I count this presentation as an opportunity to review, for the benefit of this responsible body, our activities as an association. I understand and appreciate the complexity of the duties of the House, and the difficulties involved in discharging those duties. I recall my service as a member of the House of Delegates from 1944 until 1949, before I was elected to the Board of Trustees. Members of the House, who regularly meet only twice a year, do a remarkable job of digesting and evaluating Association programs and problems. It is not easy. Keeping pace with developments in the AMA, even by the most interested physician, is as difficult as keeping abreast of the mushrooming
Leukoclastic vasculitis from cimetidine
Authors: W. K. Dernbach
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful Use of Extracorporeal Photochemotherapy in the Treatment of Severe Acute and Chronic Graft-Versus-Host Disease
Authors: Hildegard T. Greinix, Beatrix Volc-Platzer, Werner Rabitsch, Bernd Gmeinhart, Carlos Guevara-Pineda, Peter Kalhs, Jean Krutmann, Herbert Hönigsmann, Marina Ciovica, Robert M. Knobler
Journal: Blood (1998)
Neutrophils Amplify the Formation of DNA Adducts by Benzo[a]pyrene in Lung Target Cells
Authors: Paul J. A. Borm, Ad M. Knaapen, Roel P. F. Schins, Roger W. L. Godschalk, Frederik-Jan Van Schooten
Journal: Environmental Health Perspectives (1997)

Inflammatory cells and their reactive oxygen metabolites can cause mutagenic effects in lung cells.The purpose of this study was to investigate the ability of activated neutrophils to modulate DNA binding of benzo[alpyrene (B[a]P), a known carcinogen, in lung target cells.Equivalent numbers of rat lung epithelial cells (RLE-6TN cell line) and freshly isolated human blood neutrophils (PMN) were coincubated in vitro for 2 hr after addition of benzo[alpyrene (0.5 pM) or two of its trans-diol metabolites, with or without stimulation with phorbol myristate acetate (PMA).DNA adducts of B[a]P-metabolites were determined in target cells using 32P-postlabeling; oxidative DNA damage (7-hydro-8-oxo-2'-deoxyguanosine [8-oxodG]) was evaluated by high performance liquid chromatography with electrochemical detection.Increased DNA adducts were observed in lung cells coincubated with polymorphonuclear leukocytes (PMN).Activation of PMN with PMA, or addition of more activated PMN in relation to the number of lung cells, further increased the number of adducts, the latter in a dose-response manner.Incubation with B[a]P-4,5-diol did not result in any adduct formation, while B[a]P-7,8-diol led to a significant number of adducts.Moreover, PMA-activated PMN strongly enhanced adduct formation by B[a]P-7,8-diol, but not 8-oxodG, in lung cells.The addition of antioxidants to the coincubations significantly reduced the number of adducts.Results suggest that an inflammatory response in the lung may increase the biologically effective dose of polycyclic aromatic hydrocarbons (PAHs), and may be relevant to data interpretation and risk assessment of PAH-containing particulates.
Test Procedures to Evaluate Effects of Chemical Exposure on Fertility and Reproduction
Authors: Paul L. Wright
Journal: Environmental Health Perspectives (1978)

Various methods have been developed to assess the effects of chemical substances on reproduction. In some instances, the tests have been developed to define the effects of treatment on specific segments of the reproductive cycle. In other cases, studies are conducted to determine the cumulative effects of treatment during one or more generations. The structure, advantages, and disadvantages of three types of conventional reproduction studies are reviewed. An outline of the procedural sequences, observations, and record evaluation required in the three-period reproduction study, the three-generation reproduction study, and the multigeneration reproduction study are presented.
Organic Voice Tremor: A Tremor of Phonation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recombinant (rec) MAGE-A3 Protein Immunotherapy and Peripheral Blood Lymphocyte (PBL) Reconstitution Induce Strong Antigen-Specific Humoral and Cellular Immune Responses in Patients Undergoing Autologous Stem Cell Transplantation (ASCT) for Consolidation of Multiple Myeloma (MM)
Authors: Adam D. Cohen, Nikoletta Lendvai, Sacha Gnjatic, Achim A Jungbluth, Stephane Bertolini, Linda Pan, Ralph Venhaus, Ioanna Tsakos, Katarzyna Garcia, Linda Thibodeau, Katherine Alpaugh, Nailah Cummings, Rafik Fellague-Chebra, Olivier Gruselle, Hearn J. Cho
Journal: Blood (2014)
Relationship between sigma-like site and progesterone-binding site of adult male rat liver microsomes
Authors: M Yamada
Journal: Hepatology (1994)

An increasing amount of evidence suggests that the sigma (σ) sites, putative targets for a variety of psychotomimetic and antipsychotic drugs, exist not only in the brain but also in various peripheral organs. However, there are many ambiguities as to their biological roles, subcellular distributions, endogenous ligands and so on. We therefore performed our study for clarification of some of these ambiguities. As a result, we demonstrated that adult male rat liver microsomes, especially smooth endoplasmic reticulum, possessed a saturable haloperidol-binding site closely resembling the σ site, with a high affinity (Kd 1.0 ± 0.3 nmol/L) and high capacity (Bmax 9.3 ± 1.5 pmol/mg protein) and with the rank order of affinity of the ligands: haloperidol > reduced haloperidol > clorgyline > ifenprodil > 1,3-di(2-tolyl)guanidine, (—)-butaclamol > GBR-12909 > SKF-525A > progesterone > 5α-dihydrotestosterone > R(+)-3- (hydroxyphenyl)-N-propylpiperidine > testosterone ± corticosteroids, estradiol-17β, cholesterol and neuroactive compounds displaying high affinities for other neurotransmitter receptors such as dopamine D2, serotonin (5-HT1A and 5-HT2) and α1-adrenergic and GABAA receptors. This rank order showed a high correlation (r = 0.908) with that of a large portion (˜85%) of specific progesterone-binding site (Kd 31.0 ± 3.5 nmol/L, Bmax 5.7 ± 0.2 pmol/mg protein) of the same source. Therefore, these two sites were suggested to be the same or closely related. Furthermore, we provide a strong suggestion that these sites neither are identical with some subforms of the microsomal cytochromes P-450 or other steroid/drug-metabolizing enzymes nor participate universally and directly in the progesterone-metabolizing processes. (Hepatology 1994;20:1271–1280).
Congenital Afibrinogenaemia
Authors: C. C. de Silva, R. S. Thanabalasundaram
Journal: BMJ (1951)

lJnUAL prognosis is conss:dered to be good.Many, notwith- standing their burden of mental tension, can be kept usefully employed by supportive out-patient treatment with short periods in hospital during exacerbations.For some, however, their distress becomes so over- whelming and their functional efficiency so serious!y impaired that they are obliged to remain at home or in hospital in a state of invalidism.The patient described here became incapacitated in this way, and leucotorny afforded a striking and con- tinued relief of symptoms.The general change in personality similar to that which has been described by others (Hoch, 1949) has not materially interfered with her social rehabilitation.Summary A case is described in which persistent anxiety, tachy- cardia and raised basal metabolic rate unresponsive to other methods of treatment were successfully treated by bilateral prefrontal leucotomy.A year has passed without relapse.The general change in personality has been compatible with excellent social rehabilitation.The case demonstrates some problems in diagnosis and treatment.This work was done at the Bristol Mental Hospitals, and I am obliged to Dr. R. E. Hemphill for affording me facilities to study this case.I am particularly indebted to Dr.