tbuckley/cabot-search huggingface dataset:
OVAL BLOOD CORPUSCLES IN MAN.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DETERMINANTS OF VASCULAR INFLAMMATION USING [18F]-FLUORODEOXYGLUCOSE PET/CT: FINDINGS FROM THE PSORIASIS, ATHEROSCLEROSIS AND CARDIOMETABOLIC DISEASE INITIATIVE (PACI)
Authors: Balaji Natarajan, Taufiq Salahuddin, Hadeel Sadek, Martin Playford, Julia Doveikis, Aarthi Reddy, Haley Naik, Peter Herschovitch, Nehal Mehta
Journal: Journal of the American College of Cardiology (2015)
Laboratory Practices for Diagnosis of Tuberculosis— United States, 1994
Journal: JAMA (1995)

The increase in cases of tuberculosis (TB) during 1985-1992 and the emergence of multidrug-resistant Mycobacterium tuberculosis strains led to recommendations for rapid laboratory testing to support control efforts and selection of proper therapy (1,2). Many laboratories have adopted the recommendations to use rapid acid-fast bacilli (AFB) smears, growth detection (i.e., primary culture), identification, and drug-susceptibility testing for M. tuberculosis (3). The regulations implementing the 1988 Clinical Laboratory Improvement Amendments* (CLIA) require all laboratories that perform any mycobacteriology testing to enroll in federally approved proficiency testing (PT) programs. This report summarizes information reported by the laboratories to PT programs in the United States about their practices for M. tuberculosis.
Is the Routine Use of Inhaled β-Adrenergic Agonists Appropriate in Asthma Treatment?: Yes
Authors: Adam Wanner
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Is the Routine Use of Inhaled β-Adrenergic Agonists Appropriate in Asthma Treatment?: Yes." American Journal of Respiratory and Critical Care Medicine, 151(3_pt_1), pp. 597–599
Review: An early invasive strategy has similar benefits in men and women with NSTEMI or unstable angina
Authors: Christopher B. Granger
Journal: Annals of Internal Medicine (2008)

Source Citation O′Donoghue M, Boden WE, Braunwald E, et al. Early invasive vs conservative treatment strategies in women and men with unstable angina and non-ST-segment elevation myocardial infarction: a meta-analysis. JAMA. 2008;300:71-80. 18594042
Premedical students, admissions committees, and "the physician as an educated person'
Authors: P. S. Rhoads
Journal: JAMA (1982)

SUCCESS in coping with the problems facing modern medicine depends primarily on (1) choosing candidates for medicine with good minds, moral and intellectual integrity, high goals of service, and sustained enthusiasm; and (2) providing them an education in the fundamentals that will, while keeping alive their ultimate goals of service, stimulate their imaginations and provide them with a capacity for growth. <h3>The Applicant Pool</h3> I have had considerable refreshing and enlightening contact with premedical students in a small liberal arts college, Earlham, at Richmond, Ind, which has an excellent record (85.3%) in having its students accepted into medical schools. During the summer months, several students who have just completed their first preclinical year in medical school come to Reid Memorial Hospital, Richmond, for eight weeks of experience in a community hospital. From talking to these students one gains the impression that most of them have a deep desire to serve
Abstract 2443: Predicting the impact of somatic mutations on chromatin conformation using deep learning
Authors: Tuan Trieu, Ekta Khurana
Journal: Cancer Research (2019)

Abstract DNA in eukaryotes is packed into hierarchical layers of loops resulting in the 3D structure of the genome. 3D genome organization plays vital roles in many biological processes of the cell such as gene regulation, cell division and stem cell differentiation and its disruption can lead to gene dysregulation and diseases, including cancer. We developed a deep learning model to predict the impact of single nucleotide variants, indels and structural variants on 3D chromatin loop structures of the genome. We first built a deep convolutional neural network to learn DNA sequence patterns of boundaries of 3D chromatin loops. The learned patterns of boundaries are then used to train another neural network to learn if two boundaries are likely boundaries of a chromatin loop given their DNA sequences. The model produces a probability indicating the likelihood of the two boundaries to form a chromatin loop (loop probability). It is trained with DNA sequence only, and therefore, it can detect effects of DNA variants on 3D chromatin loops as changes in loop probabilities. We trained our model with 80% of 3D chromatin loop from the cell line GM12878. Our model to predict boundaries of loops can distinguish DNA sequences of boundaries from random sequences with AUC of 0.96 on a balanced test-set from the cell line GM12878 and also performs well on data from the K562 cells with AUC of 0.93. Our result shows that variants in lymphoblastoid cells GM12878 do not change loop probabilities as much as variants in leukemia cells K562 do, consistent with the greater disruptive role of tumorigenic variants in the cancer cells. We next applied our model on whole-genome sequences of 240 malignant lymphoma patients to identify loop-disrupting variants that may act as drivers of cancer. We find that genes in predicted altered loops show more differential expression in tumor samples compared to genes in unchanged loops. Our method can be applied on large cohorts of patients with whole-genome sequences to analyze the chromatin conformation changes caused by somatic variants. Citation Format: Tuan Trieu, Ekta Khurana. Predicting the impact of somatic mutations on chromatin conformation using deep learning [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2443.
Medication Errors
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stress Reduction's Common Thread
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXCESS WEIGHT LINKED TO 90,000 US CANCER DEATHS ANNUALLY
Journal: CA A Cancer Journal for Clinicians (2003)

Beth Israel Deaconess Medical Center investigated this association in the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database.This linked database represents a collaboration of the National Cancer Institute and Center for Medicare and Medicaid Services, and includes patients' clinical and demographic information as well as provider characteristics and utilization data.Using the SEER-Medicare database, the researchers examined records of 260,090 Medicare beneficiaries who died of lung, colorectal, prostate, female breast, bladder, pancreatic, gastric, or liver cancer between 1988 and 1998.During this period, 32.4% of MMC patients and 19.8% of MFFS patients received hospice care.The duration of hospice care was a week longer for MMC patients than MFFS; median lengths of stay were 32 days and 25 days, respectively.These associations remained statistically significant in multivariate analyses that included patient demographic data, stage at diagnosis, and geographic location.One important question to ask is whether the additional hospice utilization among MMC patients represents appropriate or inappropriate referrals.Although the size and methodology of this study precludes review of medical records, the SEER-Medicare database does provide some data on which to address this question.For example, the association between hospice care and insurance type was strongest among patients with Stage IV cancer.The duration of hospice care is another variable that sheds some light on appropriateness of referrals.According to the authors, periods of 2 to 3 months before death have been recommended as appropriate periods of hospice care.Much shorter or much longer durations are less likely to provide optimal care.More MFFS than MMC patients were referred to hospice within 1 week of death (22.6% and 18.6%, respectively); in many cases this probably did not provide enough hospice care.On the other hand, MMC patients were also more likely than MFFS patients to start hospice care at least 180 days before their death (7.8% versus 6.1%),
A PLEA FOR THE STUDY OF THE HISTORY OF MEDICINE AND NATURAL SCIENCES.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 465: Molecular classification of endometrial cancer provides complementary information but does not outperform current predictive models: The Karolinska and Bern experience
Authors: Denis Nastic, Sara Imboden, Mehran Ghaderi, Filippa Rydberg, Daniel Olsson, Michael Mueller, Tilman T. Rau, Elisabeth Epstein, Joseph Carlson
Journal: Cancer Research (2019)

Abstract Purpose: The purpose of this study was to evaluate the performance of a proposed prognostic molecular classification of endometrial cancer in a retrospective cohort of n=604 patients. A secondary goal was to compare the performance to existing prognostic models. Methods: All cases were analysed using 1) sequencing of the exonuclease domain of the POLE gene, 2) microsatellite instability by immunohistochemistry, and 3) TP53 mutation, as evaluated by immunohistochemistry. Additionally, complete histopathological and clinical data was available. The cases were classified using the molecular markers analyzed. Results: The assembled cohort largely resembled the typical unselected distribution of FIGO grade and stage. Analysis of clinicopathologic variables showed that FIGO grade and stage, LVSI, tumor histotype, depth of myometrial invasion, ESMO 2013 and 2016 risk group, recurrence and survival all were significantly associated with molecular subgroups. A large number of patients showed multiple molecular aberrations (so called multiple classifiers, n=50, 8.4%). Mutation in P53 was a statistically prognostic marker for overall survival (OS) in the univariable Cox regression (p-value 0.003 for OS, and &amp;lt;0.001 for DSS and PFS, HRs of 1.61, 1.83 and 1.72). The POLE mutated cases showed a trend towards favorable prognosis. By contrast, histotype (endometrioid vs. non-endometrioid) was a highly significant predictor of OS, DSS and PFS (HR=2.23, p=&amp;lt;0.001). Both ESMO 2013 and 2016, which represent an aggregate of the various clinicopathologic factors, were highly significant in predicting outcome and especially so for the high and advanced risk groups with HRs up to 70.1 (CI 23.9-206.8) and all p-values of &amp;lt;0.001. In the multivariable Cox regression analysis, however, none of the molecular markers remained significant. The Harrell C-index for 2016 ESMO risk groups was 0.76. Adding molecular markers did not show improved discriminatory ability. Conclusions: In this retrospective cohort, molecular markers provided important biological information that may be helpful in therapeutic decision making. However, the molecular markers did not outperform current prognostic models. Citation Format: Denis Nastic, Sara Imboden, Mehran Ghaderi, Filippa Rydberg, Daniel Olsson, Michael Mueller, Tilman T. Rau, Elisabeth Epstein, Joseph Carlson. Molecular classification of endometrial cancer provides complementary information but does not outperform current predictive models: The Karolinska and Bern experience [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 465.
Correlates of midlife career achievement among women physicians
Authors: P. L. Graves
Journal: JAMA (1985)

In the context of a longitudinal study, we explored factors contributing to midlife career achievement among 108 women physicians. Three groups were formed, based on medical specialty, specialty board certification, and professorial appointment. Using analysis of variance procedures, the career groups were compared on measures obtained during medical school and on marital status, family size, and three health measures in midlife. Of the youthful measures, academic standing, father's socioeconomic status, and early family (specifically father-daughter) relationships were found to be associated with midlife achievement. Furthermore, a clear association was observed between success and good health in midlife. Married women formed the majority in all groups; no differences in family size were found. We conclude that career achievement among women physicians is influenced less by marriage and family size than by motivational and personality factors shaped in early life. (<i>JAMA</i>1985;254:781-787)
Leads from the MMWR. Dental caries and community water fluoridation trends--United States
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urine calcitonin levels in patients with bronchogenic carcinoma
Authors: K. L. Becker
Journal: JAMA (1980)

We demonstrated previously that high serum calcitonin values in bronchogenic carcinoma are useful clinically as a parameter of progress of the disease and response to therapy. After developing a procedure for the measurement of calcitonin in urine, we studied serum and urine levels in 41 patients with lung cancer, using both a carboxyl terminus and a midportion recognizing antiserum. In general, midportion antiserum was more useful. Urine calcitonin measurements alone were superior to serum in terms of numbers of patients having increased values with one or both antisera (76% vs 46%). When both antisera were used to assay both serum and urine, 90% of patients had abnormal values. Once a tissue diagnosis has been established, the radioimmunoassay of urinary calcitonin offers a new dimension to the utility of this hormone as a marker for bronchogenic carcinoma. (<i>JAMA</i>243:670-672, 1980)
Volume of Lymphatic Metastases Does Not Independently Influence Prognosis in Colorectal Cancer
Authors: Jan H. Wong, Susan Steinemann, Paul Tom, Shane Morita, Pamela Tauchi-Nishi
Journal: Journal of Clinical Oncology (2002)

To evaluate the prognostic relevance of the volume of nodal metastatic disease in colorectal cancer patients.One hundred node-positive patients with T2 or T3 carcinoma of the colon or rectum after routine histologic examination of the regional nodes were studied. The metastatic tumor was measured with an ocular micrometer, and the tumor volume was determined.The mean lymph node metastatic tumor volume was 5.1 +/- 4.99 mm(3) (range, 0.05 to 83,434 mm(3)). There was only a weak positive correlation with number of nodes involved with metastatic disease and tumor volume in nodes (r =.45). Median follow-up was 39 months (range, 1 to 87 months). The number of nodes was highly predictive of outcome. Individuals with one to three positive nodes had a substantially better survival than individuals with four or more positive nodes (P <.001). The volume of nodal metastatic disease correlated with outcome (P =.019). Patients dying as a result of disease had substantially greater mean metastatic nodal volume than those who were alive (3,705 v 1,783 mm(3); P =.036). However, the total metastatic nodal volume did not, independent of positive nodes or number of positive nodes, predict outcome. Individuals with micrometastatic nodal volume did not have improved survival when compared with individuals with macrometastatic nodal volume (P =.79).The number of nodes involved with metastatic tumor, rather the volume of metastatic involvement of the regional lymph nodes, predicts outcome. These results suggest that micrometastatic disease may have a similar prognosis as macrometastatic disease when the same number of lymph nodes are involved with metastatic tumor.
Reversible renal failure following intravascular contrast radiography
Authors: R. A. Appell
Journal: JAMA (1977)

INTRAVASCULAR iodinated contrast media are routinely used in radiographic examinations in the presence of renal failure and produce few serious side effects. However, they may precipitate acute renal failure.<sup>1</sup>The case of a patient with acute renal failure following arteriography emphasizes the conservative management of this reversible condition. <h3>Report of a Case</h3> A 64-year-old man was admitted to Yale—New Haven Hospital with a ten-year history of hypertension, which had recently become more severe. At the time of admission, he was receiving 250 mg of methyldopa four times daily and 50 mg of hydrochlorothiazide daily. The patient admitted smoking 40 cigarettes per day and consuming beer heavily. His brother died of a ruptured aortic aneurysm. Physical examination showed a pulse rate of 90 beats per minute. Blood pressure taken while in the sitting position was 102/84 mm Hg in the right upper extremity and 240/90 mm Hg in the left.
The effects of electroconvulsive therapy on serial electrocardiograms and serum cardiac enzyme values. A prospective study of depressed hospitalized inpatients
Authors: G. W. Dec
Journal: JAMA (1985)

Electroconvulsive therapy (ECT) is an effective, safe, and controversial treatment of severe depression. In order to further evaluate its safety, the effect of ECT on serial electrocardiograms and serum cardiac enzyme values was studied prospectively in 29 patients. Neither persistent electrocardiographic changes nor elevations in creatine phosphokinase or serum glutamic oxalaminase transaminase levels were observed following 85 treatments. Twenty-four percent of our patients had stable, preexisting cardiovascular disease, which included conduction system disease, recent myocardial infarction, and depressed ventricular function. Electroconvulsive therapy was well tolerated by all of these patients. The proposed mechanisms for transient or persistent electrocardiographic changes and cardiovascular complications of ECT are reviewed. (<i>JAMA</i>1985;253:2525-2529)