tbuckley/cabot-search huggingface dataset:
Medical informatics. An emerging academic discipline and institutional priority
Authors: R. A. Greenes
Journal: JAMA (1990)

Information management constitutes a major activity of the health care professional. Currently, a number of forces are focusing attention on this function. After many years of development of information systems to support the infrastructure of medicine, greater focus on the needs of physicians and other health care managers and professionals is occurring—to support education, decision making, communication, and many other aspects of professional activity.<i>Medical informatics</i>is the field that concerns itself with the cognitive, information processing, and communication tasks of medical practice, education, and research, including the information science and the technology to support these tasks. An intrinsically interdisciplinary field, medical informatics has a highly applied focus, but also addresses a number of fundamental research problems as well as planning and policy issues. Medical informatics is now emerging as a distinct academic entity. Health care institutions are considering, and a few are making, large-scale commitments to information systems and services that will affect every aspect of their organizations' function. While academic units of medical informatics are presently established at only a few medical institutions in the United States, increasing numbers of schools are considering this activity and many traditional departments are seeking and attracting individuals with medical informatics skills. (<i>JAMA</i>. 1990;263:1114-1120)
SUPERSTITIONS IN MEDICINE.
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review An Introduction to Practical Bacteriology . By T. J. Mackie, M.D., D.P.H., and J. E. McCartney, M.D., D.Sc. Published by William Wood &amp; Company, New York and E. &amp; S. Livingstone, Edinburgh, 1931. Third Edition. pp. 421. Price $3.50.
Journal: New England Journal of Medicine (1931)
Can "artificial blood' live up to public billing?
Authors: V. S. Cowart
Journal: JAMA (1982)

The complex story of the substance known as "artificial blood" continues to unfold in the lay press, while the medical community wonders whether the compound can live up to its public billing and what function it should serve in blood banking. The group of compounds called perfluorochemicals, with their oxygen-carrying capacity, have been around for about two decades, but the first commercially produced one is Fluosol, distributed in the United States by Alpha Therapeutics Corp, a subsidiary of the Green Cross Corp of Osaka, Japan. The term artificial blood, so much used in the popular press, is universally disliked by those who work with the compound, which is not artificial blood at all but an oxygen transport medium and plasma expander. Fluosol only does the job of hemoglobin, its effects last only about 72 hours, and it lacks clotting factors and other properties of the real thing (<i>JAMA</i>[MEDICAL NEWS]
Hypertonic Saline for Prehospital Treatment of Traumatic Brain Injury—Reply
Authors: D. James Cooper, Paul S. Myles, For the HTS Study Investigators, For the HTS Study Investigators
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-053 Curcumin, Anti-Oxidant, and Pioglitazone Therapy with Inclusion of Vitamin E in Non Alcoholic Fatty Liver Disease-A Randomized open Label Placebo Controlled Clinical Prospective Trial (Captive)
Authors: P Basu, N J Shah, S Farhat, R Siriki, K Mittimanj, S Atluri, M Rahaman
Journal: Gut (2013)

<h3>Introduction</h3> NAFLD is a global clinical challenge which progresses to cirrhosis and liver cancer. Defective transport of free fatty acids and mitochondrial dysfunction lead to explosion of a series of free radicals, apoptosis, up regulated cytokines and fibrogenesis ultimately causing cirrhosis and cancer. Curcumin is a pan-antioxidant with anti-inflammatory, anti-apoptotic, anti-microbial, and anti-fibrogenic properties. This study evaluates the role of curcumin in NAFLD to progression of NASH <h3>Methods</h3> Eighty patients (n = 80) with mean BMI 29%, NAFLD score 0.66, NASH fibrotic score 0.33, HOMA IR 3.8, ALT 58, LDLc 143, HDLc 29, Triglyceride 186 and Adipokines ( leptin, Adiponectin, Retinal Binding Proteins) were divided into Group A-(n = 20) pioglitazone 15mg, Group B-(n = 20) vitamin E, Group C-(n = 20) curcumin (all the three above groups received placebo), and Group D (n = 20) vitamin E plus curcumin. Pre and post values (Triglycerides, LDLc, HDLc, ALT, HOMA-IR, TNF-alfa, Leptin, Adiponectin, Retinol Binding Protein, HBA1c, Serum necro-inflammatory NAFLD and NASH fibrotic score were analysed at 3, 6, and 12 months. Diet and exercise were left unchanged. Daily alcohol content was less than 30 grammes <h3>Results</h3> Group A-Minimal changes on ALT, HbA1c, HOMA, lipids, no changes in TNF-alfa, adipokines, lipid profile and necro-inflammatory score and/or NASH fibrosis score. Group B and Group C had modest changes in ALT, lipid profile, HbA1c and HOMA; while no changes in adipokines, necro-inflammatory score and fibrotic score. Group D had significant changes in all scores particularly the adipokines and small improvements in fibrotic score. All patients tolerated the medications well <h3>Conclusion</h3> This study postulates the effects of Curcumin plus vitamin E in NAFLD may prevent NASH with a modest anti-fibrotic effects and necroinflammatory score; with impressive changes in adipokines levels. Additive effects of Curcumin with vitamin E has significant effects on Serum lipids and insulin sensitivity. Unavailability of Pre and post liver biopsy was the limitation A large control trial needs to validate. <h3>Disclosure of Interest</h3> None Declared
OC-018 Continuing undue risks in UK prescribing of non-steroidal anti-inflammatory drugs
Authors: M Leighton, Y Vinogradava, J Hippisley Cox, C J Hawkey
Journal: Gut (2010)

<h3>Introduction</h3> Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin remain the most common cause of life-threatening iatrogenic pathology. Risks are age-dependent and can be reduced by switching to a selective cyclooxygenase (COX)-2 inhibitor or co-prescription of a proton pump inhibitor (PPI). The UK National Institute for Health and Clinical Excellence (NICE) has recommended that PPI co-prescription is sufficiently cost effective to be justified in all users of NSAIDs or COX-2 inhibitors. However, use of both PPIs and COX-2 inhibitors is widely discouraged by UK pharmacy advisers. <h3>Methods</h3> We conducted an analysis of prescribing trends in patients aged 45 or over in UK general practices, recorded in the QResearch electronic database of general practice records. A patient was considered to be receiving a drug in any year if they had received &gt;2 prescriptions in the 6 months prior to 1 April. <h3>Results</h3> There were 459 practices which met the inclusion criteria. Overall there were 1 825 406 patients with at least 12 months of medical records and 1 594 369 were &gt;45 years old. This resulted in 4 875 250 person-years of observations. Prescribing of aspirin rose from 9.9% in 2004 to 14.01% in 2007, while NSAID prescribing fell slightly from 5.57% to 5.49%. A PPI was co-prescribed with aspirin in only 11.7% of aspirin users in 2004 and 20.2% in 2007. For NSAIDs the values were 8.9% in 2003 and 23.1% in 2007. During this time prescription of PPIs in patients not on aspirin or NSAID rose from 4.4% to 7.8%, suggesting that increased use in aspirin and NSAID users was largely untargeted. Even among high-risk patients aged 80–84, protective strategies were limited, with 23.6% of male and 23.1% of female aspirin users receiving a PPI in 2007. In this age group, only 29.0% of men and 31.3% of women receiving an NSAID were co-prescribed a PPI. Of patients on aspirin, 17.7% in 2004 and 11.1% in 2007 were also prescribed and NSAID despite a potentially harmful pharmacodynamic interaction. Use of COX-2 inhibitors was limited (1.33% in 2003 and 0.33% in 2007), with co-prescription of a PPI in 25.0%. <h3>Conclusion</h3> Most prescribing of anti-inflammatory drugs in the UK is on an unprotected background even in the highest risk patients and NICE advice to co-prescribe a PPI is not followed. Given evidence that the combination of a COX-2 inhibitor and a PPI may virtually eliminate the risk of ulcer complications associated with NSAIDs, our data suggest UK patients are exposed to unacceptable levels of avoidable risk. Whether deficiencies in prescribing standards are due to financial pressures of a need for education requires further evaluation.
Dobutamine overdose
Authors: P. M. Paulman
Journal: JAMA (1990)

<h3>In Reply.—</h3> The letters of Lewis, Menkes, Garbitelli, and Tilelli and Manniello all contain errors of fact and reasoning and seem to be aimed at preserving the myth of pertussis vaccine encephalopathy. Dr Menkes implies that in my assessment of the National Childhood Encephalopathy Study I focused on one set of biases. This is not true. Even though there clearly were biases that tended to exaggerate the calculated risks, the original data alone do not indicate a cause-and-effect relationship but only the redistribution of events over time.<sup>1</sup>If you believe that the increased number of vaccinations in cases during the 0- to 3-day period indicates a causative effect of vaccine, then by the same reasoning you must believe that the increased number of vaccinations in the controls during the rest of the observation period was protective against disease. Since after considerable study there is no epidemiologic evidence that supports
THE PATHOLOGY OF CONVULSIVE DISORDERS.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
History of Yellow Fever; Indispensable Facts Pertaining to Its Origin and Cause, and Its Present Artificially Acquired Habitat, with Reasons Going to Show the Possibility of Its Complete Extinction from the Globe; Its Nature, Anatomic Characteristics, Symptoms, Course and Treatment, with an Addendum on its Twin Sister, Dengue, containing a Parallel Table of the Most Prominent Symptoms of each Disease.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diphtheria Outbreak—Saraburi Province, Thailand, 1994
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DANGERS OF ALKALOSIS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRIEDRICH WÖHLER AND UREA, 1928
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term survival of patients with chest pain syndrome and angiographically normal or near normal coronary arteries: The additional prognostic value of dipyridamole stress echocardiography Attila Palinkas, Eugenio Picano, Bruno Ghelarducci, Patrizia Landi, Alessandro Pingitore, Albert Varga, CNR, Institute of Clinical Physiology, Pisa, Italy
Journal: Journal of the American College of Cardiology (2001)
Subscription Information Page
Authors: Patricia Morrissey
Journal: Kidney International (2016)

Kidney International is devoted to renal research.It aims to inform the renal researcher and the practicing nephrologist on all aspects of renal research.These include the latest clinical studies on emerging developments in renal medicine and the highest level of original research studies in clinical and basic renal research.The journal reflects the field through critical reviews, commentaries, original articles, remarkable images, news features, guidelines, and problemfocused articles for the diagnosis and treatment of renal patients.
BOOK REVIEWS
Authors: D. S. MARTIN
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BOOK REVIEWS Get access Rodent Tumor Models in Experimental Cancer Therapy. Robert F. Kallman, New York: Pergamon Press, 1987, 310 pp. $55. DANIEL S. MARTIN DANIEL S. MARTIN Department of Surgery Research The Catholic Medical Center of Brooklyn and Queens 89-15 Woodhaven BlvdWoodhaven, NY 11421 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 7, 1 June 1988, Page 530, https://doi.org/10.1093/jnci/80.7.530 Published: 01 June 1988
Idiopathic Thrombocytopenic Purpura
Authors: Mario Baldini
Journal: New England Journal of Medicine (1966)

MEGAKARYOCYTES IN IDIOPATHIC THROMBOCYTOPENIC PURPURAAlterations of the number and morphology of megakaryocytes are well known to occur in this disease.36 37 38 39 It is the general experience37 38 39 that, in most cases, the megakaryocytes are increased in number, with a relative increase of immature forms and presence of signs of cytoplasmic and nuclear degeneration, vacuolization, lack of granular development and deficient platelet budding around the cytoplasmic ridge. Findings on phase contrast40 and electron microscopy41 are in agreement with those observed with the use of ordinary staining technics. Contrasting points of view, however, exist,42 , 43 and I believe that this is probably due to . . .
Charon
Authors: Christine Parkhurst
Journal: Annals of Internal Medicine (1997)

Ad Libitum15 October 1997CharonChristine Parkhurst, MAChristine Parkhurst, MAMassachusetts College of Pharmacy and Allied HealthBoston, MA 02115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-8_Part_1-199710150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When Dad wasn't ready to come home yetI wandered around his office, tapping the glassTo watch the guppies move through the weedAnd reading posters about Harvey and Alzheimer,Cox, Archibald SmithThen down the silent familiar hallThat smelled like pickles and insecticideTo see the other fishtanks:The fetus contemplating its umbilicus,The tapeworm folded over and overLike an enormous egg noodle,The cafe coronary tracheaWith its bite of steak still lodgedAnd past the always closed doorOf the room about how and whyThis adult male, a brain bleedThat elderly woman,So many milligramsOf what sedativeThat young girlExsanguinationSecondary to shameSecrets discoveredAnd kept on file in ... Author, Article, and Disclosure InformationAuthors: Christine Parkhurst, MAAffiliations: Massachusetts College of Pharmacy and Allied HealthBoston, MA 02115.Corresponding Author: Christine Parkhurst, MA, Arts and Sciences, Massachusetts College of Pharmacy and Allied Health, Boston, MA 02115-5896. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1997Volume 127, Issue 8_Part_1 Page: 650-651 ePublished: 15 August 2000 Issue Published: 15 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...