tbuckley/cabot-search huggingface dataset:
Abstract 3987: Predicting MCL1 inhibitor sensitivity in large cell line panels using a gene expression signature
Authors: Andreas Wernitznig, Dorothea Rudolph, Matthias Samwer, Norbert Schweifer, Francesca Trapani, Tobias Wunberg, Heribert Arnhof, Teakyu Lee, John L. Sensintaffar, Edward T. Olejniczak, Cyril H. Benes, Stephen W. Fesik, Norbert Kraut
Journal: Cancer Research (2019)

Abstract MCL1, an anti-apoptotic member of the BCL-2 family of proteins, is a key regulator of cancer cell survival and a known resistance factor to anti-cancer drugs, making it a highly desirable target for therapeutic intervention. Recently several MCL1 inhibitors have entered Phase I clinical development. Data derived from large cancer cell line panels suggest, that cell lines of hematopoietic origin are more broadly sensitive to MCL1 inhibition, than cell lines derived from solid tumor types. In particular, for the therapy of solid tumor patients with an MCL1 inhibitor, a patient selection biomarker would be highly desirable. Published in vitro data using various MCL1 inhibitors, siRNA or CRISPR/Cas9 technology show that tumor cell lines with low BCL-XL gene expression are mostly sensitive to MCL1 inhibition, down-regulation or inactivation. Here we show that by adding the gene expression data of additional six genes (including the MCL1 binding partner BAK1) to BCL-XL, a supervised learning predictor was applied and could reach a performance of almost 80% correctly classified solid tumor cell lines. This new predictor has been applied to either tumor samples, adjacent normal tissues or normal tissue samples from TCGA and GTEx. Briefly, most normal tissue samples are categorized as being sensitive. Moreover, solid tumor samples in contrast to solid tumor cell lines are predicted to be broadly sensitive to MCL1 inhibition with a predicted anti-tumor effect rate of 60% to 95%. In summary, our work describes the translational challenges using cell line-derived predictors on ex vivo tumor samples. Citation Format: Andreas Wernitznig, Dorothea Rudolph, Matthias Samwer, Norbert Schweifer, Francesca Trapani, Tobias Wunberg, Heribert Arnhof, Teakyu Lee, John L. Sensintaffar, Edward T. Olejniczak, Cyril H. Benes, Stephen W. Fesik, Norbert Kraut. Predicting MCL1 inhibitor sensitivity in large cell line panels using a gene expression signature [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3987.
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses
Authors: Natalie J. Thornburg, David P. Nannemann, David L. Blum, Jessica A. Belser, Terrence M. Tumpey, Shyam Deshpande, Gloria A. Fritz, Gopal Sapparapu, Jens C. Krause, Jeong Hyun Lee, Andrew B. Ward, David E. Lee, Sheng Li, Katie L. Winarski, Benjamin W. Spiller, Jens Meiler, James E. Crowe
Journal: Journal of Clinical Investigation (2013)

It has come to our attention that multiple HMGA1 bands in the immunoblot images of Figure 1,A,B, and D, and Figure 3D have been inappropriately duplicated.In addition, the p53 blots in Figure 1, A and B, appear to represent a darker exposure of the same blot.
Allied Health Education
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aeromedical Transportation
Authors: Joseph A. Moylan
Journal: JAMA (1973)

Air evacuation of critically ill patients by both fixed and rotary-wing aircraft to regional medical centers is a commonplace event in current patient care.<sup>1,2</sup>We have reviewed our experience in the air transportation of severely burned patients in order to delineate and emphasize special problems associated with aeromedical transportation during the acute phase of illness. Personnel of the US Army Institute of Surgical Research have been involved in air evacuation of acutely injured patients since 1951. During the past three years, 249 flights have been undertaken, involving 765 patients. Thirty-one percent of the patients were evacuated to the Army Burn Center within 48 hours of injury. The others were transported from as far away as Japan during the first postburn weeks. Although helicopters are commonly used for evacuations within a 200-mile radius of our institute, the majority of patients were transported by fixed-wing planes. Air evacuation can be divided
Lyme Disease
Authors: Linden T. Hu
Journal: Annals of Internal Medicine (2016)

This issue provides a clinical overview of Lyme disease, focusing on prevention, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers.
A Definition of Irreversible Coma
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of computed tomography on subdural hematoma. A population study
Authors: M. Garraway
Journal: JAMA (1985)

The Mayo Clinic (Rochester, Minn) medical record linkage and indexing system was used to examine the impact of computed tomography (CT) on the diagnostic investigation, management, and outcome of all cases of subdural hematoma (SDH) that occurred in Olmsted County, Minnesota, from 1965 through 1980. Comparisons were made between an eight-year period prior to the introduction of CT (1965 through 1972) and a similar period after CT became available in this community (1973 through 1980). The advent of CT did not change the treatment, course of the disease, or prognosis of SDH. However, the introduction of CT had a marked effect on the pattern of neurological investigations carried out. This resulted in a 15% reduction in the cost of diagnosing SDH in this community, while the overall cost of health care in the United States rose by 87% during the same period. (<i>JAMA</i>1985;253:2378-2381)
It's Free
Authors: Reuven Bar-Levav
Journal: JAMA (1975)

DURING a recent vacation, I came across the following announcement in my hotel room: "Please do not take towels to the beach. They are provided FREE at your request." It did not say that there was no extra charge for this service, which was included in the room price. The management had apparently learned that the promise of something free, something for nothing, is more convincing than if it had been phrased otherwise. In fact, we are subjected to numerous offers for socalled free goods and services. We are offered free lessons, free meals, free trips, including trips to Florida and far-off islands in the sun, in the hope that a land purchase will eventually result. Medical students are offered free instruments, free meals, and free cocktails by hospitals that want to induce them to intern there and by pharmaceutical companies that would like them to prescribe their products. Many
Imported diphtheria: Advice for travelers
Authors: M. Barry
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adenovirus Type 21 Infection
Authors: Jonathan Wright
Journal: JAMA (1979)

THE CLINICAL syndromes commonly associated with adenovirus (ADV) infection, usually in children, are febrile pharyngitis with or without conjunctivitis, severe and often fatal pneumonia, keratoconjunctivitis, and asymptomatic intestinal infection.<sup>1</sup>Acute respiratory disease, frequently seen in military recruits, varies from mild, febrile pharyngitis and tracheitis to severe, fatal pneumonia.<sup>1</sup>We recently cared for a man with pneumonia and rhabdomyolysis associated with ADV-21. <h3>Report of a Case</h3> A 46-year-old man with Huntington's disease was admitted to the hospital with a one-day history of dyspnea, paroxysmal nonproductive coughing, fever to 40 °C, and myalgias. There was no notable history of illness except for the presence of Huntington's disease. His temperature was 38.4 °C; pulse rate, 110 beats per minute; respirations, 40/minute; and blood pressure, 135/75 mm Hg. There were inspiratory and expiratory wheezes and rales at both lung bases posteriorly and decreased breath sounds over the right lower lobe posteriorly. Pertinent
UTERINE HYPERESTHESIA.
Authors: EPHRAIM CUTTER
Journal: JAMA (1898)

of cells, fibers and ground substances, with the neces- sary framework of connective tissue, blood-vessels etc.If the processes going on in this structure be limited to its capacity, no harm is expected.If, how- ever, the brain be subjected to the stresses of modern civilized life, a possible over-stimulation and conse- quent injury may result therefrom.Studying our subject from a histologie standpoint, we find that the nerve-cell belongs to the highest order of animal life aggregation.It possesses specialized nerve function and becomes a necessity in maintaining a proper rela- tion between the infinite number of protoplasmic ele- ments which compose the living animal.We find that a mental process is the product of cell metabolism resulting from stimulation.The nerve fibers or processes from the nerve-cells, when bunched together in the great centers, must be insulated.There must also be communication between the cells of different and similar function, that the animal, as a whole, may fulfill its highest mission.We know that the muscle-cell, without its individual metabo- lism, would be useless, even though stimulated by an intact nerve-cell.The same can be said of a brain- cell.We know, in either case, perfect nutrition is essential.The latter being the most highly organ- ized,would suffer the most from nutritive disturbances.The immature elements of most recent development and highest in the scale reflect very early the disas- trous effect of excessive or diminished nutrition.Considering the relatively large size of the cerebro- spinai system of a child at birth, the immaturity of its elements, and, in conjunction with this, the rapidity of growth in the first five years of life-from about eleven ounces at birth to forty ounces in the sixth year-we need not search further than environment for a possible production of early neuroses.Trivial causes produce profound impressions.Instability of
Erratum: Translocated Liver
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 March 1970Erratum: Translocated LiverAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-3-437_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractAbstractThe two parts of Figure 3 in "Waldenstrom's Macroglobulinemia with Increased Serum IgG Levels Treated with Low Doses of Cyclophosphamide" by Roger M. Cass, Burton R. Anderson, and John H. Vaughan, published in the November 1969 ANNALS (pp. 971-977), were accidently transposed before that issue was printed. The published Figure 3A, "Percutaneous liver biopsy before therapy . . ." should be Figure 3B, ". . . biopsy after 19 months of therapy," and published Figure 3B should be shifted accordingly. We apologize to the authors and to puzzled readers for this error.—E.J.H. This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1970Volume 72, Issue 3Page: 437-437KeywordsBiopsyCyclophosphamideLiver ePublished: 1 December 2008 Issue Published: 1 March 1970 PDF downloadLoading ...
A public health intervention model for work-site health promotion. Impact on exercise and physical fitness in a health promotion plan after 24 months
Authors: S. N. Blair
Journal: JAMA (1986)

We need effective ways of getting adults to exercise if we are to meet the Surgeon General's 1990 health goals for the nation. This study reports a comprehensive effort to evaluate the sustained effect of a public health intervention model to achieve these health goals. Employees at four companies (N=2,600) were exposed to a health promotion program, while employees at three comparison companies (N=1,700) were offered an annual health screen. Daily energy expenditure in vigorous activity increased 104% among employees at companies offering the health promotion program, compared with a 33% increase among employees at comparison companies. Changes in exercise habits were corroborated by estimates of maximal oxygen uptake. Exercise and physical fitness improvements were distributed throughout the work force. Meaningful population changes in exercise and physical fitness can be produced at the work site and are of a magnitude that makes it possible to meet the 1990 goals for exercise and physical fitness. (<i>JAMA</i>1986;255:921-926)
BOOK REVIEWS
Authors: M. E. HOROWITZ
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BOOK REVIEWS Get access Advances in Neuroblastoma Research 2. Audrey E Evans, Giulio J. D’Angio, Alfred G. Knudson, Robert C Seeger, eds. New York: Liss, 1988, 748. pp. $130.00. MISC E. HOROWITZ MISC E. HOROWITZ Pediatric Branch, Division of Cancer Treatment National Cancer InsiituteBldg. 10, Rin. 13N240 National Institutes of Health Bethesda; MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 18, 16 November 1988, Pages 1498–1499, https://doi.org/10.1093/jnci/80.18.1498-a Published: 16 November 1988
From the NIH: Occupational asthma from a low-molecular-weight organic chemical
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lateral Whiplash
Authors: David R. Rudy
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The report by Ommaya et al (<b>204</b>:285, 1968) should be the first experimental evidence that whiplash can produce central nervous system damage. It sheds light, also, on questions surrounding an aircraft accident on whose investigating board I served in 1962. Two air force pilots had lifted off to an altitude of about 50 feet in a jet fighter trainer when a sheet metal panel came loose from the left tiptank and impinged itself across the wing, perpendicular to the air flow, which caused a violent yaw to the left. In attempting to crash land and in bouncing over sand dunes, the aircraft became rotated to the right without changing direction, which allowed it to lurch violently to a stop when the left wing tip penetrated deeply into a mound. The occupants, at this point, experienced "lateral whiplash" forces for which protective equipment does not exist. The
Mitochondrial abnormalities in long-Evans cinnamon (LEC) rats *. National Center for Study of Wilson's Disease, St. Lukes's/Roosevelt Med. Center, Columbia University, New York, and *Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY
Journal: Hepatology (1995)

Hepatic abnormalities in Long–Evans Cinnamon (LEC) rats, an animal model of Wilson disease (WD), were restored by the expression of the human ATP7B cDNA under the control of CAG promoter. Expression of ATP7B transcript and protein in the liver of the transgenic rats resulted in the restoration of biosynthesis of holoceruloplasmin and biliary copper excretion. Meanwhile, transgenic rats showed striking improvements in their hepatic abnormalities, i.e., rescue from fulminant hepatitis, late onset of hepatic cholangiofibrosis, suppression of hepatocellular carcinoma and much improved survival rates. Moreover, dramatic decreases were noted both in the levels of hepatic copper and iron in transgenic rats before the occurrence of hepatitis. These results indicated that the human ATP7B product compensated for the deficiency of the endogenous rattus protein and did function in intrahepatic copper transport by secreting copper into the plasma via incorporation into ceruloplasmin and by the excretion of copper into the bile, and that ATP7B is critical to hepatic dysfunctions in WD. This first successful transgenic rescue has important implications for the gene therapy of WD.
Erratum: Vorinostat in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma
Authors: D S Siegel, P Richardson, M Dimopoulos, P Moreau, C Mitsiades, D Weber, J Houp, C Gause, S Vuocolo, J Eid, T Graef, K C Anderson
Journal: Blood Cancer Journal (2014)

Correction to: Blood Cancer Journal (2014) 4, e182; doi:10.1038/bcj.2014.1; published online 21 February 2014 Since the publication of this article, the authors have identified an error concerning one of the author affiliation addresses. KC Anderson was incorrectly affiliated to the following address: 'Merck & Co.
Fourth International Meeting of the Electrophoresis Society
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Fourth International Meeting of the Electrophoresis Society Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 1, January 1984, Page 199, https://doi.org/10.1093/jnci/72.1.199-d Published: 01 January 1984
The World Health Summit: intentions and expectations
Authors: None The Lancet
Journal: The Lancet (2009)

As Angela Merkel emerges victorious from the German election and is busy forming a new coalition government, preparations for the World Health Summit, to be held in Berlin on Oct 14–18, are in their final stages. The summit is under the patronage of Merkel and the French President Nicolas Sarkozy and is intended as a global forum to discuss future challenges in health and health care. The organisers want it to go further. Their aim is to present a document with key messages from workshops, recommendations, and a call to action, which will be published after the October meeting.
Editorial Board
Authors: James Field, Samuel Soskin, Beverly Hills, Garfield Duncan, Salman Azhar, Palo Alto, Hisham Barakat, George Bray, Jorge Calles-Escandon, José Caro, M Charles, San Francisco, George Chrousos, Bernard Bethesda, St Davis, Leslie Louis, Frederick Degroot, Mario Derubertis, Atlanta Digirolamo, William Ga, Louis Duckworth, John Elsas, Kenneth Fain, San Feingold, Andrew Francisco, New Frantz, Gregory York, Saul Freund, Henry Cleveland, New Ginsberg, Charles York, Jane Glueck, Abbas Cleveland, Fredric Kitabchi, Stanford Kraemer, Robert Kraemer, Nelly Mauras, James May, Donald Mcnamara, Glenn Mortimore, Maria New, New York, Michael Pagliassotti, Ft Collins, William Pandak, Alan Richmond, Los Robinson, Stanton Angeles, Peter Segal, Richard Stacpoole, Marc Durham, John Tucson
Journal: Metabolism (2007)