tbuckley/cabot-search huggingface dataset:
TRACHOMA VACCINE
Journal: JAMA (1964)

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Impact of Cytokine Gene Polymorphisms on Risk and Treatment Outcomes of Aplastic Anemia In Korea
Authors: Yun-Gyoo Lee, Ji-Hyun Kwon, Dong-Yeop Shin, Eun-Young Song, Hyun Kyung Kim, Sung Sup Park, Dong Soon Lee, Myoung Hee Park, Jin-Hee Kim, Inho Kim, Sung-Soo Yoon, Seonyang Park, Byoung-Kook Kim
Journal: Blood (2010)
Abstract 11785: The Association of Guideline Adherence of Coronary Revascularization and Clinical Outcomes for Patients With Stable and Complex Coronary Artery Disease
Authors: Chenfei Rao, Zhe Zheng, Shengshou Hu, Heng Zhang
Journal: Circulation (2015)

Introduction: Coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) gained popularity in China, there are gaps in knowledge about the appropriateness of revascularization procedures and related outcomes of stable and complex coronary artery disease. Methods: Using the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) research network, this prospective study of 3-Vessel Disease (China PEACE-3VD) consecutively enrolled patients with 3-vessel and/or left-main disease diagnosed by elective coronary angiography in 24 large cardiovascular centers in China. We abstracted medical record data for patient characteristics and treatment strategies, the core lab calculated SYNTAX Scores for all patients. We classified the appropriateness of treatment for each patient using 2011 Guideline on Myocardial Revascularization published by European Society of Cardiology and European Association of Cardio-Thoracic Surgery. We compared the 1-year rates of major adverse cardiovascular and cerebral events (MACCE) between patients underwent revascularization with I/IIa and IIb/III indications. Results: We consecutively enrolled 3186 patients from participated hospitals. Among them, 20.4% (651) underwent medical therapy, 79.6% (2535) underwent revascularization procedures (PCI: 87.4%, 12.6% CABG) during the index hospitalization. For patients underwent revascularization procedures, 47.9% patients were suitable for both CABG and PCI (has I indication for CABG, and IIa indication for PCI, group A), 52.1% were only suitable for CABG (has I indication for CABG, and IIb/III for PCI, group B). In group A, 95% underwent PCI, 5% underwent CABG, the 1-year MACCE rates of CABG and PCI showed no significant difference (PCI: 4.6%, CABG: 7.7%, adjusted OR=1.21, p=0.81); In group B, 80.4% underwent PCI, 19.6% underwent CABG, the 1-year MACCE rates of CABG is significantly lower than PCI (PCI: 7.5%, CABG: 2.3%, adjusted OR=3.18, p=0.027). Conclusions: Using the Guideline on Myocardial Revascularization, we identified certain overuse of PCI for stable and complex coronary artery disease. The inappropriate use of PCI is associated with worse 1-year outcomes than CABG. (NCT01625312)
THE IMPORTANCE OF RESISTANCE TO TUBERCULOSIS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transmission and impact of donor allergies in living donor liver transplantation
Authors: Ravikiran Sindhuvalada karnam, Sayed Blayne, Anand Ghanekar, Markus Selzner, Gonzalo Sapisochin, Mark S Cattral, Ian Mcgilvray, Trevor Reichman, Mamatha Bhat, Nazia Selzner, Leslie Lilly, Zita Galvin
Journal: Journal of Hepatology (2020)
Atlas der Syphilis.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficiency of biomarker screening for enriched metastatic colorectal cancer trials: The ATTACC program experience.
Authors: Van Karlyle Morris, Michael J. Overman, Bryan K. Kee, David R. Fogelman, Cathy Eng, Arvind Dasari, Rachna T. Shroff, Laurel Deaton, Shanequa Manuel, Chris R. Garrett, Eduardo Vilar Sanchez, Constance S. Dennis, Imad Shureiqi, Gordon B. Mills, Kenna Rael Shaw, Stanley R. Hamilton, Robert A. Wolff, Funda Meric-Bernstam, Dipen M. Maru, Scott Kopetz
Journal: Journal of Clinical Oncology (2014)

3619 Background: Incorporation of multiple enrichment biomarkers into prospective clinical trials for metastatic colorectal cancer (mCRC) has been proposed or initiated by NSABP, EORTC, NCI Colon Task Force, and UK MRC. The feasibility of large scale screening efforts in mCRC has not been previously assessed. Methods: Patients (pts) with 5-FU refractory mCRC at MD Anderson Cancer Center were offered screening in the Assessment of Targeted Therapies Against Colorectal Cancer (ATTACC) program to identify eligibility for companion phase I or II clinical trials with a therapy targeted to an aberration detected in the patient, based on FFPE testing by immunohistochemistry (IHC), 50-gene sequencing, and CpG island methylation phenotype (CIMP) assays. Ten unstained slides were required. Results: Between 8/2010 and 1/2014, 506 pts were enrolled. Median time from consent to results was 28 days (interquartile range 22-37 days). Outside tissue was obtained after a median of 6 days (4-10 days). IHC, sequencing, and CIMP results required a median of 10, 13, and 20 days, respectively (Table), with 95% yield. During this 40 month period, between 20 and 40% of pts were eligible on the basis of screened tumor biomarkers for at least one of the 18 companion studies. Given trial-specific eligibility, study logistics, and intermittent study openings, only 14% of pts enrolled on an enriched companion trial, representing an approximate 50% efficiency of enrolling eligible patients. 66% received alternate treatments off protocol, 16% enrolled on unenriched studies, and 4% received no further therapy due to a declining performance status. Conclusions: Even though dedicated screening infrastructures such as ATTACC represent an efficient strategy for enrichment studies, a majority of patients did not ultimately participate on a companion trial due to dropout of biomarker-eligible patients and a cumulative lack of trials targeting a majority of screened patients. Both of these hurdles need to be addressed to improve success of this strategy. Molecular aberration tested Aberration present Inadequate specimen KRAS mut 51% 0.9% BRAF mut 8.7% 0.0% PIK3CA mut 19% 1.3% NRAS mut 6.6% 2.2% CIMP high 37% 4.0% PTEN loss 12% 0.8%
THE CELLAR IN ITS HYGIENIC ASPECT.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TRANSMISSION OF ROCKY MOUNTAIN SPOTTED FEVER BY TICKS.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebral Infarction
Authors: John F. Simpson
Journal: JAMA (1965)

One person in seven, says Carter, dies from a stroke. With a health problem of this magnitude the appearance of a new book on the topic is, therefore, an important event. This is doubly so when the author has had wide personal experience and has previously contributed significantly to our knowledge on the subject. His goal is to interest physicians in cerebrovascular disease and to provide a basis for future assessment of treatment, purposes which he has accomplished. The approach is pragmatic, the style readable, and the factual material largely indisputable. Perhaps as a result of these qualities, the book has certain defects. Discussions of cerebral blood supply and hemodynamics are adequate but contain little mention of recent investigations. The sections on etiology and pathogenesis are comprehensive, including reviews of atheroma and thrombus formation, hypertension, and arterial spasm, and containing a particularly good discussion of the role of trauma, an
PTU-258 Prevalence and severity of pre-pouch ileitis: a distinct disease entity or a manifestation of refractory pouchitis?
Authors: MA Samaan, D de Jong, S Sahami, S Morgan, K Fragkos, S Subramaniam, K Kok, J Makanyanga, I Barnova, H Saravanapavan, I Parisi, S Di Caro, R Vega, F Rahman, S McCartney, S Bloom, G van den Brink, M Löwenberg, C Ponsioen, CJ Buskens, PJ Tanis, A de Buck van Overstraeten, A D’Hoore, WA Bemelman, GR D’Haens
Journal: Gut (2015)

<h3>Introduction</h3> Pre-pouch ileitis (PI) is a complication that can occur after panproctocolectomy and ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC). It is characterised by inflammation of pre-pouch ileum in the afferent limb of the pouch. Our aims were to assess the prevalence of PI as well as to identify predictive factors and investigate the medications needed for its management. <h3>Method</h3> Data on 546 patients who underwent IPAA for UC was retrospectively collected from three tertiary inflammatory bowel disease (IBD) referral centres. Data was collected from sites in the Netherlands (Academic Medical Centre, Amsterdam), Belgium (Leuven University Hospital) and England (University College London Hospital). PI was considered present if there was endoscopic, as well as histological inflammation in the afferent limb. <h3>Results</h3> PI was present in 33/546 (6%) UC patients, all of these had concurrent pouchitis. 144 (26%) patients had pouchitis without PI. 369 (68%) patients did not have any inflammatory pouch problems. Rates of requiring potent immunosupressive treatment were higher amongst patients with PI than those with pouchitis alone. Patients who went on to develop PI were significantly younger at the time of their UC diagnosis. PSC was significantly more common in patients with PI than those with pouchitis alone. <h3>Conclusion</h3> PI is a much less common and more treatment refractory condition than pouchitis alone. Pouchoscopy should be considered in any patient with symptoms of pouchitis. This should include careful endoscopic evaluation of the afferent pouch limb as well as biopsies of the pre-pouch ileum. Once a diagnosis of PI is made, clinicians should commence immunomodulatory therapy early in the disease course and consider escalating to an anti-TNF if this proves ineffective. <h3>Disclosure of interest</h3> None Declared.
In Vitro Fertilization: A Potential Means for Toxicity Testing
Authors: Benjamin G. Brackett
Journal: Environmental Health Perspectives (1978)

Uses and potential uses of in vitro fertilization are: (1) a research tool for investigating biochemistry of fertilization, (2) an assay for fertilizing ability, (3) a potentially useful clinical approach for certain cases of infertility, and (4) a potentially useful means for improving animal breeding. In vitro fertilization methodology is sufficiently advanced for gametes of several mammalian species, especially mouse, rabbit, and rat, for use in evaluating effects imposed by toxic agents of environmental or genetic origin. Alteration of the normal events of fertilization and/or embryonic development following transfer of in vitro fertilized embryos into surrogate dams can serve as end point(s) in applying this means for toxicity testing. In vitro fertilization of mouse and rat ova has been explored as an alternative to in vivo fertilization in male contraceptive development studies. Original observations on toxicity of abnormal O2 concentrations for rabbit fertilization in vitro are reported here. Ova were fertilized under 0, 20, 48, and 95% O2, but toxicity from the extreme conditions, 0 and 95% was apparent from comparison of proportions of fertilized ova reaching the 4-cell stage during the 24-hr incubation. Toxicity was further evidenced by inability of embryos fertilized under 0 and 95% O2 tensions, in contrast to those fertilized under 20% O2, to sustain normal gestation following their transfer into recipient does. Recent success in the fertilization of cow ova in vitro in this laboratory provides encouragement to develop a useful means for testing normalcy of gametes in this species. Such studies might lead to useful screening procedures for avoidance of human infertility resulting from hazardous environmental conditions.
THE CAUSE OF DEATH.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Basic science behind the cardiovascular benefits of exercise
Authors: Mathew G Wilson, Georgina M Ellison, N Tim Cable
Journal: British Journal of Sports Medicine (2016)

Cardiorespiratory fitness is a strong predictor of cardiovascular (CV) disease and all-cause mortality, with increases in cardiorespiratory fitness associated with corresponding decreases in CV disease risk. The effects of exercise upon the myocardium and vascular system are dependent upon the frequency, intensity and duration of the exercise itself. Following a prolonged period (≥6 months) of regular intensive exercise in previously untrained individuals, resting and submaximal exercising heart rates are typically 5–20 beats lower, with an increase in stroke volume of ∼20% and enhanced myocardial contractility. Structurally, all four heart chambers increase in volume with mild increases in wall thickness, resulting in greater cardiac mass due to increased myocardial cell size. With this in mind, the present paper aims to review the basic science behind the CV benefits of exercise. Attention will be paid to understanding (1) the relationship between exercise and cardiac remodelling; (2) the cardiac cellular and molecular adaptations in response to exercise, including the examination of molecular mechanisms of physiological cardiac growth and applying these mechanisms to identify new therapeutic targets to prevent or reverse pathological remodelling and heart failure; and (3) vascular adaptations in response to exercise. Finally, this review will briefly examine how to optimise the CV benefits of exercise by considering how much and how intense exercise should be.
MODERN EMPIRICAL INVENTIONS.*
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P081: Effect of Exercise and Quercetin on Atherosclerotic Plaque and Lipoprotein Metabolism
Authors: Mahdi Garelnabi, Jun Jin, Fei Chai, Halleh Mahini
Journal: Circulation (2012)

Atherosclerosis is a chronic disease of the large arteries; mostly attributed to oxidative stress and inflammation. This results in arterial heart disease, and stroke. Animal studies using a variety of antioxidants strongly suggest that antioxidants may protect against cardiovascular disease (CVD). Paradoxically, exercise which induces a severe oxidative stress resulting in the depletion of plasma and tissue antioxidants is an important deterrent of CVD. We propose that quercetin a flavonoid will have profound effects on the pathophysiology of atherosclerosis if combined with exercise by inhibiting lipids oxidation, promoting clearance and improving the acute exercise induced oxidative stress resulting in lowering cholesterol, artery lipids deposition and plaque regression. This study tested the possible beneficial effects of the combined exercise and quercetin on modulators of oxidation and inflammation in C57BL6 LDL –/– mice fed atherogenic diet. 40 mice were divided into four groups (10 each). These are: Control mice, left untreated; quercetin group, orally supplied with 100 ug/day of quercetin; exercise group, exercised in a treadmill for 30 minutes, 15 m /min; and the exercise and quercetin group which received quercetin and exercise dose similar to the respective groups. All animals were on atherogenic diet. The treatments were provided 5 days/week for 30 days. At the end of the month of treatment, mice were sacrificed, and atherosclerotic lesions in aorta were quantified. Liver, aorta and adipose tissue gene expressions for genes associated with oxidative stress, inflammation and lipoproteins were analyzed. The above figure shows the differences in atherosclerotic plaque formations between groups. However in addition to the changes seen between the groups as the result of quercetin and exercise treatment; one of the most Intriguing findings, is the significant (P&lt;0.001) drop in mice body weigh associated with the combined quercetin and exercise treatment compared to control.