tbuckley/cabot-search huggingface dataset:
Essentials of Anatomy and Manual of Practical Dissection, together with the Anatomy of the Viscera. Prepared especially for Students of Medicine, by Charles B. Nancrede, M.D., Professor of Surgery and of Clinical Surgery in the University of Michigan.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recommendations for Prophylaxis Against Pneumocystis carinii Pneumonia for Adults and Adolescents Infected With HIV
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum heat-stable lactate dehydrogenase in the diagnosis of myocardial infarction
Authors: T. Peters
Journal: JAMA (1969)

Serum levels of lactate dehydrogenase (LDH), heatstable LDH (HLDH), and glutamate oxaloacetate transaminase (GOT) were compared in 12 diagnostic categories. The measurement of HLDH was found to be a simple means of increasing the accuracy of the diagnosis of myocardial infarction and of helping to separate this diagnosis from associated conditions such as superimposed liver damage related to pulmonary infarction or congestive failure. An elevated HLDH level together with a heat-stable to total LDH ratio above 0.5 gives a high probability of the occurrence of myocardial infarction in a relevant clinical setting.
Microneedle Measles Patch Could Boost Global Immunization Coverage
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;italic&gt;Brief Communication:&lt;/italic&gt; Site of Origin of Mammary Tumors Induced by 7,12-Dimethylbenztal[a]nthracene in the Rat&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: Dilip Sinha, Thomas L. Dao
Journal: JNCI Journal of the National Cancer Institute (1975)

C3H-Avy and C3H-AvyfB mice transferred from our colony to the laboratory of Dr. J. R. Sabine in Australia had a markedly reduced incidence of both hepatomas and mammary tumors. Sabine and co-workers (J Natl Cancer Inst 50:1237-1242, 1973) attributed the low incidence of tumors in their laboratory compared to the high incidence in this laboratory to the fact that we routinely use red cedar shavings in the bedding, whereas they use sawdust, predominantly Douglas fir. Results of tests in this laboratory showed that the difference in occurrence of tumors could not be attributed directly to either a difference in diet or bedding. There was no evidence that the cedar shavings were carcinogenic. The animals in Australia on bedding without cedar shavings were not as healthy as our animals, in that they did not grow as well and were infested with ectoparasites; apparently these factors caused the reduced occurrence of tumors.
Response to long-term administration of human growth hormone in Turner's syndrome
Authors: M. Tzagournis
Journal: JAMA (1969)

Three patients with XO sex chromosome constitutions had human growth hormone (HGH) measurements. Exogenous HGH was given to one patient to observe its effect on linear growth. All patients had normal HGH response to hypoglycemia or arginine maleate stimulation. The growth rate of the treated patient was followed during three one-year periods. During the control period the patient's growth rate was 0.23 cm/month. It increased to 0.5 cm/month while she was receiving HGH, 10 mg/ week. During the last period, she took small doses of estrogenic substances conjugated and grew 0.3 cm/ month. Although the patient with Turner's syndrome is genetically destined to be short, growth may be stimulated in some patients with exogenous HGH.
Diabetes and Impotence
Authors: Bruce L. Fariss
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The authors of the article "Previously Unrecognized Diabetes Mellitus in Sexually Impotent Men" (1980;244:2430) presented interesting data. The article clearly demonstrates that diabetes may be found in patients with impotence. However, we think that their finding, seven diabetics in 58 patients (12.1%) with secondary impotence (SI), does not influence the previously held assumption that 90%<sup>1</sup>of all impotence is of psychogenic origin. They were specific in excluding from their study those patients with clinical evidence of psychological causes. Thus, they selected for men with an organic cause of impotence. At present there is no evidence to suggest that diabetics have either a higher or lower incidence of psychogenic impotence than nondiabetics (1980;243:750). The authors also concluded that because 12.1% of the SI group had asymptomatic diabetes that localized neuropathy or penile ischemia may produce impotence in otherwise symptomless patients. There was no attempt to confirm this
Mother's Day
Authors: L. JAMES GROLD
Journal: American Journal of Psychiatry (1968)

Mother's Day, conceived by Anna Jarvis to honor unselfish mothers, has become a profitable business venture. Encouraged by massive advertising, mothers expect compensation ranging from cards to expensive jewelry and automobiles. For the emotionally disturbed, Mother's Day focuses a year's frustrations, resentments, and feelings of neglect. The author presents four cases which represent the range of conflicts caused by this day.
Efficacy of Whooping-cough Vaccines used in the United Kingdom before 1968: Final Report to the Director of the Public Health Laboratory Service by the Public Health Laboratory Service Whooping-Cough Committee and Working Party
Journal: BMJ (1973)

The efficacy of pertussis vaccines was investigated in 33 areas in the United Kingdom from November 1966 until April 1968 inclusive. Bordetella pertussis was isolated from 1,293 persons, but there were only six isolations of B. papapertussis. Among vaccinated contacts under 5 years in homes in which B. pertussis was isolated 52% developed paroxysmal cough. The corresponding attack rate among unvaccinated contacts was 69%. These findings suggest that much of the pertussis vaccine in use for five or six years before 1968 was not very effective. However, vaccine from one producer was more effective than vaccine from another. Of the cultures of B. pertussis identified 89% were serotype 1, 3 and only about 9% were serotype 1, 2, 3. Serotype 1, 2, 3 was isolated much more frequently from unvaccinated than from vaccinated children, but some cultures identified as type 1, 2, 3 were found on re-examination to contain colonies of type 1, 3. Virological investigations were made in some areas during the first year of the study. Of the wide variety of viruses identified adenovirus and parainfluenza virus were the most common groups. Virus isolation rates were similar in patients and symptomless contacts, but B. pertussis was isolated far more often from patients than from symptomless contacts. The evidence suggests that B. pertussis remained the major cause of whooping cough in the U.K.
A Randomized, Double-Blind, Phase 2 Trial of Veliparib (ABT-888) with Carboplatin and Paclitaxel in Previously Untreated Metastatic or Advanced Non-Small Cell Lung Cancer
Authors: J. Mazieres, N. Blais, E. Juhasz, L. Urban, S. Orlov, Q. Qin, M. McKee, V. Giranda, V. Gorbunova, S.S. Ramalingam
Journal: Annals of Oncology (2015)
Annals of Thoracic Surgery, Boston
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Recommendations of the Immunization Practices Advisory Committee. Pneumococcal polysaccharide vaccine
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply to Letter to the Editor
Authors: D. Domagk
Journal: Endoscopy (2009)

In the letter entitled “Use of a prokinetic agent after double-balloon endoscopy reduces abdominal distension and discomfort, and shortens recovery time: potential adjunct or alternative to CO2” Dr Mishkin reports on his experience with the administration of a prokinetic drug in patients undergoing balloon-assisted enteroscopy [1]. Because of the potential side-effects in such a long-lasting endoscopic intervention due to the broad use of gas insufflation, all included patients received metoclopramide after the procedure. According to the presented data, less abdominal distention and discomfort were experienced by these patients; furthermore, recovery time after enteroscopy seemed to be shortened. Although the use of a prokinetic drug appears to lead to some clinical improvement in the patient group undergoing balloon-assisted enteroscopy, there are several potential drawbacks in this report.
Abstract 2831: Detection of methane-producing archaea in the cervix of Hispanics using shotgun metagenomics
Authors: Filipa Godoy-Vitorino, Frances Vazquez-Sanchez, Anelisse Dominicci-Maura, Josefina Romaguera
Journal: Cancer Research (2019)

Abstract The human cervix is colonized by microbial communities that have traditionally been regarded as a protective barrier against infections. Dysbioses disrupting the balance of the normal microbiota, leads to the appearance of anaerobic taxa that have been related to sexual transmitted infections and cancer. The complexity of the diversity and composition of cervicovaginal communities has been recently highlighted by 16S rDNA surveys, although these have limitations to either select mostly bacteria and the lack of strong lower taxonomic resolution such as being species-specific. Metagenomic shotgun sequencing overcomes these limitations, and gives us access to the extent of diversity beyond bacterial communities. This is the first project to characterize the bacterial and archaeal communities of the cervix of Puerto Ricans using shotgun metagenomics. Women coming for gynecology and colposcopy evaluation at the UPR and San Juan City clinics (San Juan Metropolitan area), and who did not meet several excluding criteria including having taken antibiotics for the last month, were recruited for the study. Samples were acquired by inserting a speculum for access and visualization of the cervix and a sterile swab was rotated along the lumen with a circular motion and frozen immediately for posterior genomic DNA extractions and sequencing. Library construction and shotgun sequencing of 10 cervical patient samples was done with the Illumina HiSeq platform An average of 1,690,000 good quality reads per sample were analyzed. Approximately 90% of the contigs had more than 1,000bp and 10% had sizes ranging from 1,000-5,000bp. Microbial communities were dominated by Lactobacillus, including L. iners, Gardnerella vaginallis, Nocardia and Atapobium vaginae. Archaeal diversity was dominated by Methanosarcina (namely, M. barkeri) with other less dominant taxa such as Methanolobus, Methanococcus, Natrococcus and Methanobrevibacter. The dominance of Lactobacillus was expected, and as Archaea are environmental organisms that have been associated with the mucosa in mammals, including protecting the human gut, they must have an important role in the cervix. As methanogenic archaea are known to remove fermentation end products, such as methanol and ethanol, as end-products of other fermentative bacteria, methanogenesis maybe important in preventing the accumulation of gases and other reaction end products that could damage the cervical mucosa. Citation Format: Filipa Godoy-Vitorino, Frances Vazquez-Sanchez, Anelisse Dominicci-Maura, Josefina Romaguera. Detection of methane-producing archaea in the cervix of Hispanics using shotgun metagenomics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2831.
THE SUCCULENT STRAWBERRY.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Journal of Clinical Pathology, Indianapolis
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How to Grow Old Without Aging
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE FUNCTIONS OF THE SKIN
Authors: M. S. PEMBREY
Journal: British Journal of Dermatology (1910)

Journal Article THE FUNCTIONS OF THE SKIN Get access M. S. PEMBREY, M.A., M.D. M. S. PEMBREY, M.A., M.D. Lecturer in Physiology, Guy's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 22, Issue 9, 1 September 1910, Pages 286–293, https://doi.org/10.1111/j.1365-2133.1910.tb16644.x Published: 01 September 1910
Phase I pharmacokinetic (PK) and safety study of intravenous (IV) CI-1033 in patients with advanced solid tumors
Authors: G. R. Simon, S. Olson, C. R. Garrett, I. Eiseman, M. Langevin, J. J. Mahany, D. M. Sullivan, M. G. Schlicht, R. Lush, P. Lanehan
Journal: Journal of Clinical Oncology (2004)

3057 Background: CI-1033 is a pan-erbB tyrosine kinase inhibitor. In phase 1 oral (PO) studies, dose limiting toxicities were primarily gastrointestinal (GI), which supported the exploration of IV dosing to achieve higher drug exposures. Methods: Forty-eight patients (pts) with advanced nonhematologic malignancies received IV CI-1033 via 30 min infusions (10–500 mg) on a 3-day weekly (MWF) schedule. PK samples were collected on Days 1 and 8 and evaluated using compartmental analysis (NONMEM ADVAN3). Results: 28M/20F, ECOG PS 0 & 1, median age 54 (42–73), tumors: lung 11, colorectal 10, mesothelioma 9, melanoma 4, unknown primary 2, others 12. Despite a 5 to 10-fold increase in IV Cmax and a 3-fold increase in AUC compared to PO at equivalent doses, treatment-related GI AEs were notably less frequent with this IV regimen than with once weekly dosing of PO CI-1033 (100–1000 mg; n=55; Proc. ASCO 2001,283:72a). The incidences of the most common GI AEs when given IV were Gr 1–2 nausea (15%), vomiting (11%), diarrhea (7%) vs 60%, 40%, and 49%, respectively, with PO dosing. Whereas Gr 3 GI AEs occurred in 2% of pts on the PO study, none were reported in the IV study to date. The incidences of Gr 3 hypersensitivity were comparable for IV and PO regimens (each 2%). Systemic exposure was dose proportional with bi-phasic elimination. The initial distribution phase had a 2 to 3 minute half-life while the terminal elimination phase half-life was approx 3 hrs. Central volume of distribution (18.5 liters) approximated extravascular water volume. Systemic clearance was rapid at 3 L/min. Systemic exposure was not dependent upon age, gender, race, renal function, body weight or surface area in this IV study. Conclusions: Gastrointestinal AEs were less frequent following IV dosing relative to PO dosing at comparable systemic exposures and hence higher drug exposures could be acheived by the IV route. Oral bioavailability of CI-1033 is about one-third that observed following IV dosing. The clinical significance of the higher drug exposures achieved by the IV route is yet to be determined but warrants further investgation. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Pfizer Pfizer Pfizer Pfizer