tbuckley/cabot-search huggingface dataset:
ANOMALIES OF THE MAMMARY GLAND.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update: Influenza Activity—United States and Worldwide, 1993
Journal: JAMA (1993)

Influenza activity in the United States is monitored by CDC through surveillance systems developed in cooperation with state and local health departments; in addition, CDC receives reports of worldwide influenza activity from international World Health Organization (WHO) collaborating laboratories and WHO, Geneva. This report summarizes influenza activity in the United States and worldwide for April through November 1990.
Population‐based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: An Olmsted county study, 1976–1995
Authors: Ruben A. Mesa, Murray N. Silverstein, Steven J. Jacobsen, Peter C. Wollan, Ayalew Tefferi
Journal: American Journal of Hematology (1999)

To provide basic information about occurrence and outcome of essential thrombocythemia (ET) and agnogenic myeloid metaplasia (AMM), we used the Rochester Epidemiology Project medical record linkage system for residents of Olmsted County, Minnesota. We identified all residents who were diagnosed with ET or AMM from 1976 to 1995. Community inpatient and outpatient medical records were reviewed to verify the diagnosis of ET or AMM, and patients were followed passively through their medical records to determine the outcome after diagnosis. We identified 39 cases of ET and 21 of AMM, with age- and sex-adjusted incidence rates of 2.53 and 1.46 cases/100,000 population annually, respectively. The respective median ages at diagnosis were 72 and 67 years. The female-to-male ratios were 1.8 and 1.6 for ET and AMM, respectively, and when adjusted for age, there was no difference in risk. The median follow-up period was 62.9 months for ET and 33.2 months for AMM. Five- and 10-year survivals were 74.4% and 61.3%, respectively, for ET and were significantly lower than expected for age-matched controls ( P = 0.012). Prognosis was worse for AMM, with a median progression time of 7 months and a 3-year survival of 52.4%. This was significantly worse than for age-matched controls (P < 0.001). This study provides population-based incidence and comparative survival figures in ET and AMM. Am. J. Hematol. 61:10–15, 1999. © 1999 Wiley-Liss, Inc.
Perseverance of laboratory test ordering: a syndrome affecting clinicians
Authors: G. D. Lundberg
Journal: JAMA (1983)

Why do physicians order laboratory tests? Wertman and co-workers, in one of the few large studies of this question, reported that diagnosis, monitoring, and screening were most frequent, with responses of 37, 33, and 32, respectively.<sup>1</sup>Other reasons cited were previous abnormal result (12%), prognosis (7%), education (2%), and medicolegal (1%). I have performed a less sophisticated but more wide ranging study of the same question during the past five years. Groups of physicians and laboratory workers in various states and countries have been challenged verbally with the question "Why do physicians order laboratory tests?" Remarkable similarities and a few sharp differences in responses between various groups have appeared. The reasons offered include the following: A classic example of physicians ordering laboratory tests for reasons other than appropriate is the so-called CBC. It is common for a CBC to be ordered repetitively without a rational basis, such as in
Visiting Lists.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inter-Relations between Adrenocortical Functions and Infectious Illness
Authors: William R. Beisel, Morton I. Rapoport
Journal: New England Journal of Medicine (1969)

OVER the past two decades, adrenocortical hormones have been employed as supportive therapy during infections of virtually every kind. Data concerning this controversial area of steroid therapy have been subjected to a number of critical reviews1 2 3 4 5 and will not be re-evaluated here. Rather, the present discussion will focus on an unsolved problem of fundamental and continuing importance, "How does normal adrenocortical function serve to protect the host during infection?" That the human host does fare best when his own pituitary-adrenal axis is normally responsive (or when exogenous hormone is given an optimal replacement dose after adrenalectomy) is a conclusion based . . .
'Catch-22s' for family physician educators
Authors: B. F. Currie
Journal: JAMA (1981)

FEDERAL and state funds being channeled into the training of family physicians have created a dilemma for many medical school administrators: how to adapt their institutional missions to changing specialty needs without threatening established clinical departments. Conversely, the ambivalence of some university administrators about incorporating a generalist department has created a dilemma for family physician educators in those institutions: how to achieve first-class citizenship without being co-opted by the emphasis on subspecialization. The "catch-22s" for medical schools and new departments of family medicine have some of their origins in the "town-gown" dissension that has often divided private practice physicians from their full-time faculty counterparts in university communities. Because a premium is placed on highly differentiated information in academia, medical school faculties are inclined to question the scholarly value of a discipline like family medicine with its integrative rather than elaborative emphasis.<sup>1</sup>Subspecialist faculty (particularly in internal medicine) also question
PLoS Medicine Issue Image | Vol. 3(12) December 2006
Journal: PLoS Medicine (2006)

A germline mutation in the palladin gene associated with familial pancreatic cancer causes abnormal distribution of the cytoskeletal palladin protein in transfected cells, as shown here. The research article by Pogue-Geile et al. reports the identification of the mutation in a large kindred with pancreatic cancer, as well as the findings that palladin is overexpressed in sporadic pancreatic cancers and that cells expressing the mutant protein have an increased ability to migrate. Image Credit: Cover design by Natalie Davis, Public Library of Science, with images taken from Pogue-Geile et al.
Infectious Disease
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parallel 21: Molecular and Cellular Biology
Authors: Andrea Branch, Xiaodong Ge, Daniel Antoine, Yongke Lu, Elena Arriazu, Ming Leung, Arielle Klepper, M Fiel, Natalia Nieto, Jin-Kyu Park, Teruo Utsumi, Yirang Jung, Yasuko Iwakiri, Thiago De Assuncao, Yan Sun, Bing Huang, Yasuhiro Ikeda, Robert Huebert, Branden Tarlow, Carl Pelz, Leslie Wakefield, Willscott Naugler, Milton Finegold, Francesco Russo, Rosa Liddo, Debora Bizzaro, Thomas Bertalot, Giacomo Sturniolo, Maria Conconi, Patrizia Burra
Journal: Hepatology (2014)
THE PRESIDENT'S CASE AND THE NEWSPAPERS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Nose, Throat and Ear for Practitioners and Students.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Generation of antibodies to heparin‐PF4 complexes without thrombocytopenia in patients treated with unfractionated or low‐molecular‐weight heparin
Authors: Jean Amiral, Edith Peynaud‐Debayle, Martine Wolf, Françoise Bridey, Anne‐Marie Vissac, Dominique Meyer
Journal: American Journal of Hematology (1996)
Medical care of Cambodian refugees
Authors: K. Dahlberg
Journal: JAMA (1980)

Tens of thousands of Cambodian refugees are entering Thailand. Many of the new arrivals are survivors of months of starvation and are critically ill with marasmus, kwashiorkor, beriberi, anemia, malaria, diarrhea, and respiratory diseases. With volunteer medical help, field hospitals are treating patients under primitive conditions that are gradually improving. Based on experience at the Sa Kaeo refugee camp, a brief survey of the nutritional and other diseases likely to be encountered is given for the potential volunteer who may be unfamiliar with tropical medicine. (<i>JAMA</i>243:1062-1065, 1980)
Making sense of group A streptococcus scare
Authors: R. Voelker
Journal: JAMA (1994)

THE RECENT RINGING in physicians' ears has nothing to do with tinnitus. It's the sound of fearful patients calling for reassurance that a so-called flesh-eating strain of streptococcus will not strike them and their families like a thief in the night. "Physicians are being inundated with phone calls," says Stanford Shulman, MD, professor of pediatrics and associate dean of Northwestern University Medical School, Chicago, Ill. Many of those calls, Shulman explains, are from parents whose children have chicken pox. Harboring fears fueled by exaggerated news accounts, they worry that a severe, invasive strain of group A strep will find a portal through the varicella vesicles. Other parents want to know how to prevent a deadly strep infection if a child suffers a scraped knee during a fall from a bicycle. Some patients call to find out if it's safe to travel to England, where the bacterial buzz started in late
Abstract A25: SOCS3 deficiency in myeloid cells promotes prostate tumor development
Authors: Hao Yu, Yudong Liu, Braden C. McFarland, Etty N. Benveniste, Hongwei Qin
Journal: Cancer Research (2015)

Abstract Suppressor Of Cytokine Signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway, and have been implicated as functioning as tumor suppressors, particularly SOCS3. We have previously demonstrated that specific deletion of SOCS3 in myeloid cells leads to heightened activation of STAT3 and downstream STAT3 target gene expression. STAT3 activation has been strongly implicated in contributing to prostate cancer progression and metastasis. STAT3 signaling in myeloid cells has been demonstrated to attenuate anti-tumor immunity. Thus, we evaluated the impact of SOCS3 deletion in myeloid cells in a murine prostate tumor model. We demonstrate that prostate tumor growth is significantly enhanced in myeloid-specific SOCS3-deficient mice, which correlates with elevated levels of Myeloid Derived Suppressor Cells (MDSC) in both the spleen and tumor microenvironment, and less CD8+ T-cell infiltration in tumors. Furthermore, SOCS3-deficient bone-marrow-derived mononuclear cells exhibit heightened STAT3 activation and are preferentially differentiate into MDSC phenotype. Importantly, we identify granulocyte-colony stimulating factor (G-CSF) as a critical factor secreted by the prostate tumor microenvironment that promotes development of Gr-1+CD11b+ cells via a STAT3-depentent pathway. Abrogation of tumor-derived G-CSF reduced the proliferation and accumulation of Gr-1+CD11b+ cells and inhibited prostate tumor growth. Therefore, the tumor-derived cytokine, G-CSF, is a prospective candidate upstream of the STAT3/SOCS3 pathway in MDSC differentiation from the bone marrow. These findings highlight the critical function of SOCS3 as a negative regulator of MDSC development and function, which may contribute to tumor suppressor attributer of SOCS3. Citation Format: Hao Yu, Yudong Liu, Braden C. McFarland, Etty N. Benveniste, Hongwei Qin. SOCS3 deficiency in myeloid cells promotes prostate tumor development. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr A25. doi:10.1158/1538-7445.CHTME14-A25
PD-L1 expression in primary clear cell renal cell carcinomas (ccRCCs) and their metastases.
Authors: Marcella Callea, Elizabeth M Genega, Mamta Gupta, SuChun Cheng, Andre Poisl Fay, Jiaxi Song, Ingrid Carvo, Rupal Satish Bhatt, David F. McDermott, Michael B. Atkins, Toni K. Choueiri, Gordon James Freeman, Sabina Signoretti
Journal: Journal of Clinical Oncology (2014)

4585 Background: Clinical trials evaluating anti-PD-1 and anti-PD-L1 antibodies (Abs) in ccRCC have shown tumor responses in a subset of patients. Tumor PD-L1 expression increases the likelihood of benefit with anti-PD-1 Ab, but fails to identify all responders. One explanation for these results is that predictive biomarkers are usually evaluated in the primary tumors, which may not accurately reflect expression in the metastases (mets) that are targeted by therapy. In this study, we compared PD-L1 expression in a series of ccRCCs and their mets. Methods: Paraffin tissue blocks from 33 primary ccRCCs and corresponding lymph node or distant mets (excisional biopsies) were retrieved. Multiple areas of the primary tumors (e.g. areas of predominant and highest Fuhrman nuclear grade (FNG)) were selected for analysis. Slides were immunostained with a validated mouse monoclonal anti-PD-L1 Ab (405.9A11). Membranous expression in tumor cells was quantified using an H-score. A case was considered positive when any tumor cell positivity was detected. For expression in intratumoral immune cells, a combined score based on the extent of inflammatory infiltrate and percentage of positive cells was used. Results: PD-L1 expression in tumor cells of primary tumors and their mets is summarized in Table 1. The pattern of PD-L1 staining was highly heterogeneous in the primary tumors and was restricted to areas of highest FNG. The staining was more homogeneous in the mets. In 12/33 (36%) cases with positive primary tumors and/or mets, PD-L1 expression in tumor cells tended to be higher in the mets (median average H-score=4.5) compared to the primary tumors (median average H-score=1.3) (p=0.13). No significant difference was found in PD-L1 expression in immune cells between primary tumors and their mets (p>0.5). Conclusions: Discordant expression of PD-L1 between the primary tumor and their mets was detected in 5/33 (15%) of cases suggesting that accurate assessment of predictive biomarkers for PD-1 blockade in ccRCC may require analysis of multiple areas of primary tumors and/or mets. Analysis of a larger patient cohort is ongoing to confirm these findings. Metastases Total PD-L1- PD-L1+ Primary tumors PD-L1- 21 2 23 PD-L1+ 3 7 10 Total 24 9 33
Tuberculosis
Authors: Joseph D. Wassersug
Journal: New England Journal of Medicine (1947)

THE prolonged and chronic course characteristically pursued by tuberculosis is reflected in the slow progress that is being made in its conquest. The fatty armor that encapsulates the tubercle bacillus has only been dented, not destroyed, by man-made devices. Until some chemotherapeutic or antibiotic agent is found that will penetrate the inner defenses of this hardy microbe, progress in the field of tuberculosis will continue to resemble a series of skirmishes rather than a pitched, decisive battle.Childhood TypeA clearer concept is developing concerning the so-called "childhood type" of tuberculosis and its relation to tuberculin sensitivity and pulmonary calcifications. . . .
Oral contraceptives. The good news
Authors: B. S. Hulka
Journal: JAMA (1983)

After 20 years of marketing in the United States, sufficient time has elapsed to evaluate the possibility of long-term adverse and beneficial effects of oral contraceptives (OCs). As pharmacologic agents, their early complications have been studied intensively. The cardiovascular complications were established in Britain within eight years of their market introduction and widespread acceptance.<sup>1</sup>These adverse effects appeared somewhat less devastating when balanced in perspective with the risks associated with pregnancy and delivery. Before age 35 years, pregnancy- and delivery-related mortality exceeded mortality from OC use by more than tenfold. However, the picture was not complete in the minds of many. There lingered a concern that the steroid hormone composition of OCs would increase the frequency of cancer after enough time had elapsed. How long is enough is always uncertain. Some exposures have been associated with an increased risk of specific cancer types within five years. More commonly, 15
CONCERNING THE IODIN REACTION (FLORENCE'S REACTION) WITH SEMINAL AND OTHER FLUIDS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The place of implantation in tongue and floor of mouth cancer
Authors: B. Pierquin
Journal: JAMA (1971)

Since 1959, we have treated cancers of the mobile tongue and floor of the mouth by interstitial therapy with iridium Ir 192 (afterloading technique).<sup>17-19</sup> Among more than 400 cancers of this anatomic region treated either by interstitial iridium Ir 192 pins (épingles) afterloaded through stainless steel guides or continuous iridium Ir 192 wire afterloaded into nylon tubing, we have extracted 153 cases representing all new, untreated lesions of minimal or moderate extent, which have been referred to our clinic at the Institut Gustave Roussy between January 1959 and June 1969; the rest of the 400 cases had recurred or advanced disease. We have at our disposal, then, a period of observation for these patients from a minimum of six months to a maximum of 10.5 years. These lesions have a maximum diameter of less than 4 cm. Here is the distribution of these cases as a function of their