tbuckley/cabot-search huggingface dataset:
Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses
Authors: A Blomberg, I.s Mudway, C Nordenhäll, H Hedenström, F.j Kelly, A.j Frew, S.t Holgate, T Sandström
Journal: European Respiratory Journal (1999)

To obtain information on the real-time events occurring within human respiratory tract lining fluids (RTLFs) during ozone exposure, sequential nasal lavage was performed on 13 human volunteers exposed on separate occasions to 0.2 parts per million O3 and filtered air (2-h exposures, with intermittent exercise). Nasal lavage was performed and blood samples obtained at four time points throughout each exposure: pre-exposure (Pre-E), 1 h into exposure (1h-E), immediately post-exposure (0h-PE) and 1 h post-exposure (1h-PE). Endobronchial mucosal biopsies were obtained at 1.5 h-post exposure (1.5h-PE). Nasal RTLF neutrophilia was not apparent during, or 1.5 h after, 03 exposure. Furthermore, activation of the pre-existing neutrophil population did not occur. Airway permeability was not altered by this 03 exposure regimen. Sequential lavage resulted in significant washout of RTLF ascorbic acid, reduced glutathione, extracellular superoxide dismutase and myeloperoxidase at 1h-E, 0h-PE and 1.5h-PE relative to baseline Pre-E values. In contrast, RTLF uric acid (UA), total protein and albumin concentrations did not display washout kinetics. Of the antioxidants examined, only UA was clearly depleted by 03, concentrations, falling by 6.22 micromol x L(-1) at 1h-E, compared with 1.61 micromol x L(-1) (p<0.01) during control air exposure. The establishment of a new pseudo-steady-state concentration of RTLF UA (70% of Pre-E values) during the second hour of O3 exposure was coincident with a small but significant increase in plasma UA concentration (19.27 (O3) versus 1.95 micromol x L(-1) (air), p<0.05). These data demonstrate that inhalation of 0.2 parts per million 03 results in the depletion of nasal respiratory tract lining fluid uric acid and that this regional loss of uric acid leads to a small increase in plasma uric acid concentration. Whilst the reaction of uric acid with inspired 03 may confer protection locally, the role of upper airway uric acid as a sink for inhaled O3 is not supported by these findings.
SOX4 enables Oncogenic Survival Signals in Acute Lymphoblastic Leukemia
Authors: Parham Ramezani-Rad, Huimin Geng, Lai N Chan, Christian Hurtz, Hassan Jumaa, Ari Melnick, Elisabeth Paietta, William L. Carroll, Cheryl L Willman, Véronique Lefebvre, Markus Muschen
Journal: Blood (2012)
Editorial board
Authors: D Metcalfe, F Simons, Lanny Rosenwasser, Gail Shapiro, Colo Seattle, Wash Vice, Michael Schatz, William Busse, San Diego, Calif Madison, Thomas Casale, Louis Mendelson, West Hartford, Paul Greenberger, Dennis Ownby, William Henderson, Lawrence Schwartz, Richard Honsinger, Los Alamos, Gillian Shepherd, New York, Robert Lemanske, Donald Leung, Colo Deputy, Harold Nelson, Stanley Szefler, Colo Associate, James Crapo, Erwin Gelfand, Gary Larsen, Bruce Bochner, Philip Norman, Kay Whalen
Journal: Journal of Allergy and Clinical Immunology (2002)
Out of the Test Tube
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Levamisole toxicity.
Authors: L DeLorenzo, J A Stewart
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.2.365 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2299376 Levamisole toxicity. L DeLorenzoxL DeLorenzoSearch for articles by this author , J A StewartxJ A StewartSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.2.365 PDF "Levamisole toxicity.." Journal of Clinical Oncology, 8(2), p. 365© 1990 by American Society of Clinical Oncology
The Independent Living Fund.
Authors: D. Black
Journal: BMJ (1989)

in enteropathy caused by non-steroidal anti-inflammatory drugs; examination of the small bowel by a barium study may show strictures and skip lesions in both Crohn's disease and enteropathy caused by non-steroidal anti-inflammatory drugs.Confirming the diagnosis of enteropathy caused by non-steroidal anti-inflammatory drugs is often difficult.Neoplasia should be excluded; withdrawing the drug may stop the malabsorption and blood loss.If the condition is diagnosed as an adverse reaction this should be reported to the Committee on Safety of Medicines in the usual way.Management of the condition is essentially to treat the symptoms.The subclinical biochemical abnormalities persist for up to 16 months after withdrawing the drug.'2Strictures of the small intestine are best treated by resection.The prog- nosis of the subclinical enteropathy is good provided that the non-steroidal anti-inflammatory drug is withdrawn; disease associated with strictures may have a more indolent remitting course and is not reversed by withdrawing the drug.About 30 million patients around the world take non- steroidal anti-inflammatory drugs regularly so the enteropathy caused represents a substantial clinical challenge.Many cases may be masquerading as Crohn's disease, accounting partly for the recent increase in this condition.'3The problem may be reduced by judicious prescribing of non-steroidal anti-inflammatory drugs but is likely to become even more widespread.
CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells
Authors: Andreas Herrmann, Saul J. Priceman, Piotr Swiderski, Maciej Kujawski, Hong Xin, Gregory A. Cherryholmes, Wang Zhang, Chunyan Zhang, Christoph Lahtz, Claudia Kowolik, Steve J. Forman, Marcin Kortylewski, Hua Yu
Journal: Journal of Clinical Investigation (2015)

The correct author and affiliation lists are above.Supplemental Figure 1A included an incorrect sequence for the CTLA4-targeting aptamer and omitted the presence of an additional linker region.The figure and legend have been corrected and updated online to include additional information about the design of the CTLA4-targeting aptamer.A sentence regarding the Biopolymer Core was omitted from the Acknowledgments.The correct sentence is below.We thank the staff of the Biopolymer Core at the Beckman Research Institute for designing and synthesizing the CTLA4 apt -STAT3 siRNA conjugates.
Research contributions to supportive measures for cancer chemotherapy
Authors: E. J. Freireich
Journal: JAMA (1972)

Contributions to the development and application of supportive therapy procedures for patients with leukemia and patients undergoing chemotherapy relate to two major complications, hemorrhage and infection. For the treatment of hemorrhage, I introduced the use of quantitative, comparative clinical studies for evaluation of treatment effects; adapted the plasmapheresis technique to the collection of platelets; reported the limits of plasma donation by plasmapheresis; described the direct, quantitative relationship between the concentration of platelets in the venous blood and the risk of developing hemorrhage; introduced the study of single patient/single donor combinations for the study of platelet viability and compatability<sup>1</sup>and utilized the technique for study of platelet isoimmunization in vivo; evaluated the effect of storage in vitro on the in vivo viability of platelets; reported the effects of fever and infection on platelet life span; developed improved methods for preparation of platelet concentrates; and described the effectiveness of regular and
Mandatory continuing education. Sense or nonsense?
Authors: C. R. Brown
Journal: JAMA (1970)

The heroic age of American medicine, responsive to the leadership of Welch, Osler, and their many colleagues, contemporaries, and "pupils,"<sup>1</sup>established two basic principles essential for achieving the goals of medical excellence and a high quality of medical care: (1) the physical, biological, social, and behavioral sciences must provide the underpinning of medical education; (2) the physician must remain "a lifelong student"! (In one sense, this soubriquet has been harmful, since educators until recent years have continued to think of the physician in the same role model as their concept of the medical student, a receptacle for information and wisdom, rather than as a mature professional making critical decisions each working day of his life. For a thoughtful discussion of this point, see Groen.<sup>2</sup>) Now, three quarters of a century later, the flowering of medicine through advances in scientific knowledge is evident to everyone. But medical educators still
Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans
Authors: Joshua J. Gooley, Kyle Chamberlain, Kurt A. Smith, Sat Bir S. Khalsa, Shantha M. W. Rajaratnam, Eliza Van Reen, Jamie M. Zeitzer, Charles A. Czeisler, Steven W. Lockley
Journal: Endocrine Reviews (2011)

Context:Millions of individuals habitually expose themselves to room light in the hours before bedtime, yet the effects of this behavior on melatonin signaling are not well recognized.
The Diseases of the Male Urethra.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 815: Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer
Authors: Ping-Ching Hsu, Susan Kadlubar, Eric Siegel, Lora J. Rogers, Valentina K. Todorova, Joseph Su, Issam Makhoul
Journal: Cancer Research (2019)

Abstract Neoadjuvant chemotherapy is given before surgery to patients with primarily unresectable, advanced-stage cancers to render the tumor resectable, and to facilitate breast conservation. Previously, we have reported a prospective phase II trial for women with stage IIA-B/IIIA-B-C breast cancer with improved pathologic complete response (pCR) when using bevacizumab in the neoadjuvant setting. Chemotherapy agents are given orally or intravenously during multiple cycles of systemic treatments. However, the effect of the treatment can only be evaluated upon the completion of therapy. Here, we aim to identify epigenetic signatures in blood for patients at baseline as non-invasive markers to predict their pCR from the treatment, and to determine if treatment-related changes in epigenetic profiles reflect responsiveness to therapy. We performed genome-wide DNA methylation profiling using blood-derived DNA, and found that pre-treatment methylation status of BRD9 was predictive of responsiveness to therapy. Post-treatment global methylation differences were also observed between responders and non-responders. Most differentially methylated CpGs were located in promoter CpG island regions for responders, but in the open sea region for non-responders. DNMT3B was hypomethylated while most of the other genes were hypermethylated after 4 cycles of treatment. Hypomethylation of DNMT3B could potentially lead to the increased methylation of oncogenes and genes responsible for cell growth and proliferation, facilitating responsiveness to the therapy. These results support the development of BRD9 as a biomarker for treatment selection before neoadjuvant therapy with bevacizumab, and indicate DNMT3B as a potential target to improve clinical response. Citation Format: Ping-Ching Hsu, Susan Kadlubar, Eric Siegel, Lora J. Rogers, Valentina K. Todorova, Joseph Su, Issam Makhoul. Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 815.
International Society of Nephrology Global Kidney Health Atlas: structures, organization and services for the management of kidney failure in North and East Asia
Authors: Luxia Zhang, Jinwei Wang, Chih-Wei Yang, Sydney Chi-wai Tang, Naoki Kashihara, Yong-soo Kim, Ariunaa Togtokh, Syed Saad, Feng Ye, Maryam Khan, Deenaz Zaidi, Mohamed A. Osman, Meaghan Lunney, Ikechi G. Okpechi, Vivekanand Jha, David C.H. Harris, Adeera Levin, Marcello Tonelli, David W. Johnson, Aminu K. Bello, Ming-hui Zhao
Journal: Kidney International Supplements (2021)
International Conference on the State of the Art of Safety Evaluation and Regulation of Chemicals
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article International Conference on the State of the Art of Safety Evaluation and Regulation of Chemicals Get access JNCI: Journal of the National Cancer Institute, Volume 67, Issue 5, November 1981, Page 1177, https://doi.org/10.1093/jnci/67.5.1177-c Published: 01 November 1981
Validation of the accuracy of the fast score for detecting non-alcoholic steatohepatitis patients at high risk of becoming cirrhotic in a North American cohort
Authors: Mariana Lazo, Mark Van Natta, Arun Sanyal, James Tonascia, Naga Chalasani, Samer Gawrieh, Mohammad Siddiqui, Cynthia Behling, Srinivasan Dasarathy, Anna Mae Diehl, Kris V. Kowdley, Rohit Loomba, Arthur McCullough, Norah Terrault, Brent Tetri, Raj Vuppalanchi
Journal: Journal of Hepatology (2020)
Science and Practical Common Sense
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environmental thrombocytopenic purpura. 'On the whole, i'd rather be in Philadelphia
Authors: R. McMillan
Journal: JAMA (1979)

CHRONIC immune thrombocytopenic purpura (ITP) is a syndrome characterized by a destructive thrombocytopenia, thought to be caused by a circulating antibody against a platelet-associated antigen or antigens.<sup>1</sup>The nature of the antigen is not known. In adults with ITP, spontaneous complete remission is rare and usually occurs early in the course of the illness. For the past ten years we have cared for a patient whose clinical pattern was consistent with the diagnosis of ITP. However, all symptoms, signs, and laboratory abnormalities disappeared completely when she left the San Diego area. This case provides strong evidence for an environmental antigen as an etiologic agent in her disease. <h3>Report of a Case</h3> A 67-year-old woman was well until October 1968, when a severe flu-like syndrome developed, manifested by the onset of malaise and weakness followed by nausea, vomiting, and diarrhea. She was hospitalized and treated with succinylsulfathiazole, promethazine hydrochloride, a
On Diseases of Joints
Authors: H. Coote
Journal: BMJ (1859)

fully established.Nourishing food was allowed from the first, and, three days after the injury, ten minims of tincture of sesquichloride of iron and four grains of sesquicarbonate of ammonia were given in camphor mixture three times a-day.The ligatures separated, one on the thirteenth, the other on the fourteenth day after their application, and the boy recovered without an untoward symptom.
Front Cover: Cover Image, Volume 39, Issue 2
Authors: Yacoubou Abdoul Razak Mahaman, Fang Huang, Henok Kessete Afewerky,  Tanko Mahamane Salissou Maibouge, Bishwajit Ghose, Xiaochuan Wang
Journal: Medicinal Research Reviews (2019)

On the cover: The cover image is based on the Review Article Involvement of calpain in the neuropathogenesis of Alzheimer's disease by Yacoubou Abdoul Razak Mahaman et al., https://doi.org/10.1002/med.21534.
Cardiac Clinics: A Mayo Clinic Monograph
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase II study of temsirolimus added to low-dose weekly carboplatin and paclitaxel for patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC)
Authors: L.A. Dunn, M.G. Fury, H. Xiao, S.S. Baxi, E.J. Sherman, S. Korte, C. Pfister, S. Haque, N. Katabi, A.L. Ho, D.G. Pfister
Journal: Annals of Oncology (2018)

Ann Oncol 2017; 28: 2533–2538 (doi: 10.1093/annonc/mdx346) In the original article, the funding information contained the wrong grant number: CA008747, rather than CA008748. This has now been corrected. A phase II study of temsirolimus added to low-dose weekly carboplatin and paclitaxel for patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC)Annals of OncologyVol. 28Issue 10PreviewActivating events along the PI3K/mTOR pathway are common in head and neck squamous cell carcinomas (HNSCC), and preclinical studies suggest additive or synergistic effects when combining mTORC1 inhibitors with carboplatin and paclitaxel chemotherapy. Full-Text PDF Open Archive
Normal?
Authors: Frank E. Manson
Journal: JAMA (1989)

<h3>To the Editor.—</h3> I strongly endorse the view of Hoffman et al<sup>1</sup>that "orders including terms such as 'amps,' 'pills,' 'vials,' or 'tab' without further specification should neither be written by physicians nor accepted by nurses. More precise doses of a solution of given concentration must be stated." However, the authors do not go quite far enough. Hoffman et al state in case 1 that the patient "was treated with... normal saline." However, "a<i>normal</i>solution is one having a concentration equivalent to a gram-equivalent of solute per liter."<sup>2</sup>Thus, a normal solution of sodium chloride contains 58.45 g/L. This is hardly the 9 g/L meant by the author as "normal saline." It would be nice to see the latter term dropped from the medical literature and replaced with "0.9% sodium chloride solution."
BINOCULAR LOUPE
Authors: Frank H. Lahey
Journal: JAMA (1931)

<h3>To the Editor:</h3> —I think the foregoing criticism is quite just and that I should have been careful to include the name Beebe loupe. I had presumed that every one was sufficiently familiar with the long existence of the Beebe loupe so that they would not feel that any one could possibly claim originality in suggesting its employment. My sole purpose was to call attention to the value of the loupe in magnifying surgical fields and searching for parathyroids. I am indebted to the subscriber for a just criticism, however unintentional.
HIV infection following motor vehicle trauma in central Africa
Authors: D. R. Hill
Journal: JAMA (1989)

The prevention of human immunodeficiency virus (HIV) infection during international travel is gaining increased attention. In this report, a 32-year-old man acquired the HIV following a motor vehicle accident in Rwanda. During the accident the patient received multiple lacerations and was covered with the blood of similarly injured and bleeding passengers. This exposure through lacerated skin to the blood of persons with a high probability of being infected with HIV demonstrates an unusual mode of transmission and emphasizes the importance of HIV prevention during travel and of motor vehicle safety. (<i>JAMA</i>. 1989;261:3282-3283)