tbuckley/cabot-search huggingface dataset:
Les migraines: Etude pathogénique, clinique et thérapeutique
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Announcement</i>: STD Awareness Month — April 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Surveillance Report (http:// www.cdc.gov/std/stats14/surv-2014-print.pdf ), cases of three nationally notifiable STDs (chlamydia, gonorrhea, and syphilis) have increased for the first time since 2006.With approximately 1.4 million reported cases of chlamydia and a rate of 456.1 cases per 100,000 population, the rate of reported cases has increased 2.8 percent since 2013.Rates of primary and secondary (P&S) syphilis, the most infectious stages of syphilis, and gonorrhea, have both increased since 2013, by 15.1 percent and 5.1 percent, respectively.In 2014, there were 350,062 reported cases of gonorrhea (a rate of 110.7 per 100,000) and 19,999 reported cases of P&S syphilis (for a rate of 6.3 per 100,000).STDs continue to affect young people, particularly women, most severely, but increasing rates among men, especially among gay, bisexual, and other men who have sex with men, contributed to the overall increases in 2014 for all three diseases.April 2016 is CDC's annual STD Awareness Month, and the prevention theme for this year's campaign is Talk Test Treat.Individuals should begin a program of STD prevention by talking openly and honestly with their sexual partners and health care providers about their sexual history.Sexually transmitted infections might be asymptomatic; among sexually active persons, getting tested is one of the most important things they can do to protect their health.Health care providers can help their patients decide which tests are the most appropriate for them.Patients who test positive for an STD should work with their doctor to get the correct treatment, and ensure that the treatment works.Learning resources for patients, clinicians, and community members about STDs are available from CDC at http://www.cdc.gov/std/sam.
Serum biomarker analysis of WJOG4107: A randomized phase II trial of adjuvant chemotherapy with S-1 versus CDDP+S-1 for resected stage II-IIIA non-small cell lung cancer (NSCLC).
Authors: Tetsuya Mitsudomi, Yasuo Iwamoto, Shuta Tomida, Kazuko Sakai, Takeharu Yamanaka, Hirohito Tada, Hiroshige Yoshioka, Kazuya Uchino, Ichiro Yoshino, Shunichi Sugawara, Shigeki Mitsuoka, Toshiaki Takahashi, Mitsunori Ohta, Takashi Seto, Shinji Atagi, Morihito Okada, Hideo Saka, Kazuhiko Nakagawa, Yoichi Nakanishi, Kazuto Nishio
Journal: Journal of Clinical Oncology (2014)

7550 Background: We conducted a randomized phase II trial for patients with resected stage II-IIIA NSCLC comparing postoperative long-term oral S-1 (80 mg/m2/day for consecutive 2 weeks q3w for 1 year) (S) (N=100) and cisplatin (CDDP) (60 mg/m2 day1) plus oral S-1, (80 mg/m2/day for 2 weeks) q3w for 4 cycles (CS) (N=100), and previously reported that the disease-free survival rate at 2 years (DFS@2yr), a primary endpoint, was 66 % (95%CI, 55-74%) for S and 58% (48-67%) for CS (Yoshioka et al., ESMO 2012). Here, we report the results of pre-planned serum biomarker analysis to identify biomarkers that are significantly associated with patient outcome. Methods: Serum samples were obtained from the 197/200 patients. Concentrations of 16 growth factors and 27 cytokines were measured by Luminex. Concentration of each protein was dichotomized at its median. Results: As is often the case with interaction test, a p-value of less than 0.10 was considered to be statistically significant and was used for this study. HGF, GCSF and leptin showed the moderate association with prognosis by multivariate Cox regression analysis considering treatment arm, age, sex, histology, smoking history, and stage with P for treatment-protein interaction <0.10 (HGF, P=0.0576; GCSF, P=0.0579; leptin, P=0.0741). Furthermore, patients with lower serum HGF level showed significantly favorable prognosis than those with higher serum HGF level in postoperative long-term S-1 therapy (P=0.0072 by the log-rank test). DFS@2yr for HGF low/S and HGF high/S were significantly different, 77% (95%confidence interval: 66-91%) and 56% (44-72%), respectively, while those of HGF low/CS and HGF high/CS were almost identical, 61% (48-77%) and 61 (48-78%), respectively. Conclusions: Low serum HGF level may define patient subset that would benefit from postoperative long-term S-1 therapy. It is possible to hypothesize that low HGF may enhance S-1- induced apoptosis through inhibition of angiogenesis, because HGF is a potent angiogenetic factor and S-1 acts on tumor angiogenesis (Cancer Lett., 2008, 267, 26). Indeed, NK4 (HGF/MET antagonist) reportedly enhances 5FU-induced apoptosis.
Hypercalcemia in squamous cell carcinoma of the skin
Authors: C. Makoui
Journal: JAMA (1978)

Squamous cell carcinoma of the skin is an extremely rare cause of hypercalcemia associated with malignant neoplasms. The case of a patient with extensive squamous cell carcinoma of both buttocks and thighs, with severe hypercalcemia is reported. The data presented indicate secretion of a humoral factor by the tumor, producing hypercalcemia. (<i>JAMA</i>239:1882-1883, 1978)
The effect of low-fat diet on lipid levels
Authors: E. Siguel
Journal: JAMA (1996)

<h3>To the Editor.</h3> —The study by Dr Schaefer and colleagues<sup>1</sup>fills a major gap in understanding the effect of low-fat diets on lipid levels. During their study (approximately 3 months), two (6.9%) of the 29 subjects developed evidence of heart disease; one had a myocardial infarction. At this rate, approximately 25% of subjects would develop evidence of heart disease every year. In our clinical experience we found that low-fat diets using processed low-fat and nonfat foods deprived of essential fatty acids (EFAs) decrease high-density lipoprotein (HDL) levels and increase triglyceride levels. Some patients feel more tired and complain that they lack energy. We have been warning physicians that such low-fat diets increase the ratio of total cholesterol to HDL cholesterol, and deplete plasma and red blood cell EFA levels when used as maintenance diets (ie, without weight loss).<sup>2,3</sup>Numerous studies show that low levels of polyunsaturated fatty acids
ADDRESS.
Journal: JAMA (1893)

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What is a "safe" interval between halothane exposures?
Authors: D. L. Bruce
Journal: JAMA (1972)

Halothane, a safely and easily administered anesthetic agent, is associated with liver damage only in the rare patient. Until a method is developed to predict which individuals will be affected adversely, the best protection we can provide for the patient is to monitor closely the postoperative period in every patient receiving halothane. If an untoward reaction referable to the liver is detected, the patient should not be exposed again to halothane. If there was no reaction, providing sufficient time had elapsed to allow the appearance of signs and symptoms of hepatic dysfunction, subsequent choices of anesthesia for this patient should be made by the anesthetist, based upon his experience and the requirements of the operation. Halothane may be the agent of choice in patients with chronic liver disease.
Results are better when patients control their own analgesia
Authors: W. A. Check
Journal: JAMA (1982)

Patient-controlled analgesia (PCA) following surgery "has the potential to explode throughout the nation's hospitals in the next few years," predicts anesthesiologist Richard Bennett, MD. Bennett's prediction stems from intensive work that he and his colleagues at the University of Kentucky College of Medicine in Lexington have done with this technique in the last few years. "We have obtained the first hard evidence in randomized trials that patient-controlled analgesia simultaneously improves pain relief and decreases sedation throughout the entire postoperative period, that patients actually use significantly less morphine postoperatively when allowed to adjust their own dose, and that pulmonary function is significantly better in these patients," Bennett summarized for<i>JAMA</i>MEDICAL NEWS. In addition, the Kentucky investigators found that patients taper their own doses of narcotics, suggesting that PCA has a low potential for producing drug dependence, and titrate morphine delivery to normalize their daily activities. Bennett collaborated in these studies
Elevated plasma levels of matrix metalloproteinase-9 (92-kd type IV collagenase/gelatinase B) in hepatocellular carcinoma
Authors: A Hayasaka, N Suzuki, N Fujimoto, S Iwama, E Fukuyama, Y Kanda, H Saisho
Journal: Hepatology (1996)

Background Matrix metalloproteinase 9 (MMP–9), a 92–kd gelatinase/type IV collagenase, has been implicated as playing an important role in cancer invasion and metastasis. A previous study showed that serum type IV collagenase activity correlated with metastasis by hepatocellular carcinoma (HCC). The aims of this study were to determine the plasma levels of immunoreactive MMP–9 in patients with HCC and to compare the levels with the clinical features including vascular invasion. Patients and methods: This study included 100 patients with HCC, 21 patients with chronic hepatitis (CH), 24 patients with liver cirrhosis (LC), and 138 healthy control subjects. Plasma MMP–9 levels were measured with a specific one–step sandwich enzyme immunoassay. Results: Plasma MMP–9 levels in HCC (62 [33 to 130 ng/mL] median [25%, 75%], 13 to 660 ng/mL, minimum, maximum) were significantly elevated compared with those in normal controls (36 [25 to 45], range, 2.8–70 ng/mL), in CH (28 [18 to 30], 13 to 66 ng/mL) and in LC (35 [26 to 58], 16 to 86 ng/mL) ( P &lt; .0000001; P = .0000003; and P = .00205, respectively). When the cut–off level was defined as 60 ng/mL from a receiver operating characteristic curve, plasma MMP–9 concentrations had a sensitivity of 53% and a specificity of 89% for the detection of HCC from CH and LC. The levels were significantly higher in HCC patients with macroscopic portal venous invasion (79 [36 to 160], 15–660 ng/mL) than those without the invasion (44 [27 to 80], 13 to 210 ng/mL) ( P = .00726). Plasma MMP–9 levels in patients with HCC were not correlated with tumor number, size, volume, or serum α–fetoprotein levels. Conclusions: The present data suggest that plasma MMP–9 levels can be a candidate for a novel marker for HCC. The levels appear to reflect its potential and ongoing activity of vascular invasion. A long–term follow–up of the patients will be necessary to determine whether increased plasma MMP–9 levels are predictive of more invasive and metastatic HCC.
Climate Variability and Change in the United States: Potential Impacts on Vector- and Rodent-Borne Diseases
Authors: Duane J. Gubler, Paul Reiter, Kristie L. Ebi, Wendy Yap, Roger Nasci, Jonathan A. Patz
Journal: Environmental Health Perspectives (2001)

Vector-borne diseases result from infections transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas.The vector-borne pathogens, which include viruses, rickettsiae, bacteria, protozoa, and worm parasites, spend part of their life cycle in a cold-blooded arthropod vector and thus are influenced by environmental change.The transmission patterns of these diseases may, therefore, be affected by ambient temperature.However, temperature is only one of many factors that influence transmission dynamics (Figure 1).Rodent-borne diseases do not always involve an arthropod host and are therefore less directly affected by temperature.Transmission of these infections frequently depends on rodent population density and behavior, which, in turn, depend upon environmental conditions and available food.Many vector-borne diseases are zoonoses caused by pathogens having nonhuman animals as their natural host.Because they are not part of the natural transmission cycle, humans are only incidentally infected.Zoonoses usually persist in nature in silent transmission cycles between vectors and nonhuman hosts, going undetected unless they spill over and infect the human population.In contrast, the anthropogenic vector-borne diseases, such as dengue fever and malaria, require no animal host and are transmitted from human to human by mosquito vectors.Although these disease-causing pathogens are now rare in the United States, their mosquito vectors are still present.Diseases such as plague, typhus, malaria, yellow fever, and dengue fever, transmitted between humans by blood-feeding arthropods, were once common in the United States.Many of these diseases are no longer present, mainly because of changes in land use, agricultural methods, residential patterns, human behavior, and vector control.However, diseases that may be transmitted to humans from wild birds or mammals (zoonoses) continue to circulate in nature in many parts of the country.Most vector-borne diseases exhibit a distinct seasonal pattern, which clearly suggests that they are weather sensitive.Rainfall, temperature, and other weather variables affect in many ways both the vectors and the pathogens they transmit.For example, high temperatures can increase or reduce survival rate, depending on the vector, its behavior, ecology, and many other factors.Thus, the probability of transmission may or may not be increased by higher temperatures.The tremendous growth in international travel increases the risk of importation of vector-borne diseases, some of which can be transmitted locally under suitable circumstances at the right time of the year.But demographic and sociologic factors also play a critical role in determining disease incidence, and it is unlikely that these diseases will cause major epidemics in the United States if the public health infrastructure is maintained and improved.
AMA Drug Evaluations
Journal: JAMA (1968)

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INCIPIENT CATARACT.
Authors: ALBERT RUFUS BAKER
Journal: JAMA (1895)

Since completing the above, it has occurred to me that readers who are not familiar with the later experiments in gunshot injuries, might not readily understand what the "humane" theory is, and I there- fore add a few words of explanation.When the first experiments with the small caliber gun were made, it was found that occasionally the epiphysis of a bone showed an almost clean perfora- tion and the rash conclusion was drawn that the new class of weapons, instead of shattering the bones and tearing the flesh, would make almost a punctured wound; therein they would be more humane.The main fallacy in these experiments was that they were made on dry bones, in which the cancellated tissue of the epiphysis readily gave way to the lateral effect and thus the explosive result did not occur.In all experiments on fresh bones, and on bony cavities filled with a pulp resembling brain matter, the ex- plosive action was manifest, as it has been found in the practical exhibit of the case under consideration.INCIPIENT CATARACT.
Education Programs in Areas Allied to Medicine
Journal: JAMA (1965)

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Cases of Midwifery in Which Galvanism was Applied; with Remarks
Authors: T. Dorrington
Journal: BMJ (1846)

The following cases are sublmitted to the Society, witlh the view of calling attention to the power of galvanism in certain obstetrical emergencies.We Are indebted to nly friend and colleague, Dr. Radford, for the introduction of this agency into the practice of midwifery, and from what I hiave witnessed, I believe that obstetricians will ultimately acknowledge, that it is one of the most valuable additions that has been made to our obstetrical armamentarium in modern times.It is to be regretted, that since the publication of Dr. Radford's lecture on this stibject, in December, 1844, the attention of the profession has fixed itself upon the treatment of certain cases of placenta prmvia, by separating the placenta before delivery, rather than on the treatment of severe cases of uterine hern.orrhagegenerally by galvanism, which wvas the proper suiject of the lecture.It mnust not be supposed from this remark that I do not fully appreciate the great value and importance of that treatment, which indeed was first adopted on scientific grounds, and as a inatter of election, by my late father-in-law, Mr. Kinder Wood; but since the publication of Dr. Sinmpson's papers on the subject, and since the controversy between that gentleman and Dr. Radford, the method of treatment in question seems to me to have been somewhat abused, its object misunderstood, and the lives of some children to have been sacrificed by -its inconsiderate adoption.It does not seem to have
Geriatrics, Minneapolis
Journal: JAMA (1967)

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An Elementary Handbook on Radium and Its Clinical Use.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal