tbuckley/cabot-search huggingface dataset:
Amenorrhea: Early Investigation Urged
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The elderly in Scottish hospitals.
Journal: BMJ (1972)

small airways disease during and after acute respiratory in- fections.What happens when viral infections reach the smaller bronchi and bronchioles is by no means certain.Histopatho- logical material is not available in man, nor has a suitable animal host been found which reacts to viruses in a similar way.Increased muscular tone does not seem to be important, since bronchodilators have no effect on the impaired dynamic compliance.3Inflammatory changes with increased secretions in the airways seem to be most likely, possibly associated with local patchy collapse, but they cannot be extensive when the vital capacity and static compliance are nor- mal.Some support for this view comes from the observa- tion that when radioactive labelled particles penetrate the small airways they may persist for as long as six weeks after acute coryza.4Another explanation, which would fit the physiological findings, is the possibility of localized defects in the production of surfactant, which could upset the stability of the distal air passages.If this happens, some impairment in gaseous exchange might be expected.5Perhaps further in- vestigations will prove this to be so.Most respiratory viruses are capable of affecting the smal- ler airways-for example, influenza and respiratory syncytial virus-and also Mycoplasma pneumoniae.Much could be gained by studying people during and after common colds with a view to determining which viruses are most likely to involve the lungs, the circumstances in which they do, and the length of time the defects persist.
Fetal complications of amniocentesis
Authors: W. T. Creasman
Journal: JAMA (1968)

Amniocentesis is an invaluable diagnostic tool. In the hands of the experienced, the complication rate is small but not unimportant. The possibility of puncturing the fetus at any point, injecting dye into the fetus, introducing infection, precipitating fetomaternal hemorrhage, or traumatizing the placenta must always be kept in mind. Fetal position must be known prior to the amniocentesis to minimize the possible trauma which the fetus may receive during this procedure. Those responsible for the perinatal care of mother and baby must be alert for the complications of this procedure.
Contempo '86
Authors: Don Riesenberg, Charlene Breedlove
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review The Biologic Fundamentals of Radiation Therapy . A textbook. By Friedrich Ellinger, M.D. With a preface by Maurice Lenz, M.D. English translation by Reuben Gross, M.D. 8°, cloth, 360 pp., with 79 illustrations. New York: Elsevier Publishing Company, Incorporated, 1941. $5.00.
Journal: New England Journal of Medicine (1942)
Arrow Wounds
Authors: J. A. Lundy
Journal: New England Journal of Medicine (1952)

THIS day and this place, our new Medical Library Hall, are the time and place to remind you of the long tradition behind the Annual Oration of the Worcester District Medical Society.The first oration of which we have record was given one hundred and fifty-six years ago. Since 1795 an oration has been given annually to this society almost without interruption to the present day. There were, however, a few calm years with no orations. For instance, a hundred years ago the orator declined to give his oration and was excused. It makes one realize that if one has . . .
PALETTE: A randomized, double-blind phase III trial of pazopanib versus placebo in patients with soft-tissue sarcoma (STS) whose disease has progressed during or following prior chemotherapy—An EORTC STBSG Global Network Study (EORTC 62072).
Authors: W. T. Van Der Graaf, J. Blay, S. P. Chawla, D. Kim, B. Bui Nguyen, P. G. Casali, P. Schöffski, M. Aglietta, A. P. Staddon, Y. Beppu, A. Le Cesne, H. Gelderblom, I. R. Judson, N. Araki, M. Ouali, S. Marreaud, R. Hodge, M. Dewji, A. P. Dei Tos, P. Hohenberger
Journal: Journal of Clinical Oncology (2011)

LBA10002 The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed onsite at the Meeting on June 4, 2011, and as a supplement to the June 20, 2011, issue of Journal of Clinical Oncology.
Estimation of hepatocellular carcinoma risk after hepatitis B surface antigen seroclearance
Authors: Yewan Park, Joo Hyun Oh, Myungji Goh, Dong Hyun Sinn, Jihye Kim, Geum-Yon Gwak, Seung Woon Paik, Wonseok Kang, Yong-Han Paik, Moon Seok Choi, Minseok Albert Kim, Jeonghoon Lee
Journal: Journal of Hepatology (2020)
Depression Relief
Authors: M. J. Friedrich
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Building or Extending a Hospital Department: Radiology a Path through the Planning Minefield (5)
Authors: E J Roebuck, D J Manton, G L Fordham
Journal: Journal of the Royal Society of Medicine (1987)

This is the fifth of a series of articles on the planning and building of a new radiology department or the extension of an old one. While the series focuses on a radiology department, it will be of interest to anyone who is planning any part of a hospital, particularly in the detailed information about the planning process and the part to be played by hospital staff during the subsequent building and commissioning.
Antiviral activity and safety of the hepatitis B core inhibitor ABI-H0731 administered with a nucleos(t)ide reverse transcriptase inhibitor in patients with HBeAg-positive chronic hepatitis B infection in a long-term extension study
Authors: Man-Fung Yuen, Kosh Agarwal, Xiaoli Ma, Tuan Nguyen, Eugene R. Schiff, Hie-Won Hann, Douglas Dieterich, Ronald Nahass, James Park, Sing Chan, Steven-Huy Han, Edward Gane, Michael Bennett, Katia Alves, Hany Zayed, Qi Huang, Richard Colonno, Steven Knox, Luisa Stamm, Maurizio Bonacini, Ira Jacobson, Walid Ayoub, Frank Weilert, Natarajan Ravendhran, Alnoor Ramji, Paul Kwo, Magdy Elkhashab, Tarek Hassanein, Ho Bae, Jacob Lalezari, Scott Fung, Mark Sulkowski
Journal: Journal of Hepatology (2020)
Aggressive phase of multiple myeloma with pulmonary cell infiltrates
Authors: H. Garewal
Journal: JAMA (1982)

AN AGGRESSIVE, terminal phase of plasma cell myeloma has been recently recognized.<sup>1,2</sup>It is usually characterized by fever, pancytopenia, rapidly enlarging soft-tissue masses, and decreasing or stable levels of myeloma protein, with tumor morphological characteristics similar to those of a poorly differentiated or large-cell lymphoma. Death usually ensues in two to six months. We describe herein a patient with multiple myeloma whose condition had remained in plateau phase<sup>3</sup>for five years and who then had an acute pneumonialike illness with rapidly progressive pulmonary infiltrates and fever, leading to his death due to respiratory failure within several days. Both antemortem and postmortem tissue examination conclusively showed that the pulmonary infiltrates were due to plasma cell invasion and not infection. Results of serial measurements of serum protein spikes as well as bone marrow studies, including thymidine-labeling indices<sup>4</sup>and in vitro stem-cell drug sensitivity assays,<sup>5</sup>throughout the course of
A new type sphygmomanometer valve
Authors: A. J. Moss
Journal: JAMA (1976)

AN IMPORTANT prerequisite for early detection of arterial hypertension is reliable measurement of the resting blood pressure. General precautions necessary for proper registration of blood pressure relate to the patient, the examiner, and the instrument.<sup>1</sup>One caveat is the importance of a relatively uniform rate of cuff deflation. The optimal rate of deflation has not been determined but seems to be somewhere between 2 and 5 mm Hg/sec.<sup>1-3</sup> Personal experience as well as observation of others indicates that most conventional sphygmomanometer valves are "sticky," and the desired rate and uniformity of deflation are practically impossible to attain. The purpose of this report is to describe a new sphygmomanometer valve that permits a predetermined rate of cuff deflation. <h3>The Valve</h3> The valve is shown in Fig 1. Operation is simple, depending on depression and release rather than rotation, as in the conventional valve. Depression of the push button opens
WHO Proposes 'World Health Research Centre'
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isolation of Mycoplasma hominis from the blood of men with multiple trauma and fever
Authors: T. Y. Ti
Journal: JAMA (1982)

<i>MYCOPLASMA hominis</i>is a common inhabitant of the human genitourinary and upper respiratory tracts.<sup>1,2</sup>Its full role in the pathogenesis of disease in man is unclear. Infections associated with<i>M hominis</i>have been reported mainly in postpartum women<sup>1</sup>and neonates.<sup>2</sup>Isolation of the organism from the bloodstream following vaginal delivery or abortion is well documented<sup>1</sup>; however, its recovery from the blood of adult men has been described in only a single report.<sup>3</sup>We present two patients from whom<i>M hominis</i>was isolated in blood cultures following multiple trauma. One of these also had septic arthritis. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 26-year-old man, found unconscious following a motor vehicle accident, was admitted with multiple lacerations and fracture of the left femur and fracture dislocation at C2-C3. Following initial supportive therapy he regained consciousness. The hospital course was characterized by intermittent fever spikes (temperatures of 39
Familial risk and cancer control
Authors: H. T. Lynch
Journal: JAMA (1976)

An intensive study of the family history of cancer in 4,515 patients screened consecutively by a multiphasic mobile cancer detection unit showed, after age correction, that cancer had developed in 8.9% of the probands when there was one cancer in a single first-degree relative, 16.2% had cancer with two family members affected, and 27.4% had cancer when three or more family members had been affected. This constituted a significant correlation between family and personal histories of cancer in these patients. Extrapolation to the United States population with cancer-control implications are given. (<i>JAMA</i>236:582-584, 1976)
Diagnostic role of bundle-branch block
Authors: A. Selzer
Journal: JAMA (1966)

The electrocardiographic abnormalities associated with bundle-branch block (BBB) are based on a delay in the transmission of impulses to one of the ventricles, causing its asymmetrical activation. It is customary to divide such blocks into complete and incomplete forms, the former arbitrarily based on duration of the QRS complexes of more than 0.1 seconds, and the latter on QRS duration of 0.1 seconds or less. <h3>Left Bundle-Branch Block</h3> Left BBB usually shifts the extremity leads<sup>1</sup>axis to the left and superiorly and produces deep QS-waves in right precordial leads and broad R-waves in left precordial leads. Left BBB completely rearranges the mode of ventricular activation, so that if preblock tracings showed such abnormalities as ventricular hypertrophy or myocardial infarction, these are no longer identifiable in the presence of BBB. Incomplete left BBB resembles pronounced forms of left ventricular hypertrophy; according to some views<sup>1</sup>a conduction defect causing incomplete left
The accident process. 3. Disability: acceptable and unacceptable
Authors: A. H. Hirschfeld
Journal: JAMA (1966)

Peptic ulcers and other suggestions of depression appear in histories of accident victims, indicating that disability exists before the mishap. After the accident has occurred, this disability is linked with an apparent physical defect, and it becomes acceptable to both patient and society. Breaking this linkage is an important factor in successful therapy. Of equal interest is the fact that prior depression has measurable physical components. Increases occur in adrenal and gastric secretions. Ketosteroid, metadrenalin, normetadrenal, thyroid, and estrogen titers change, some in blood, others in urine. Such physical variables of preaccident depression could be measured for prediction and possibly for preventive therapy.
Prostanoid secretion by rat hepatic sinusoidal endothelial cells and its regulation by exogenous adenosine triphosphate*1, *2
Authors: N HASHIMOTO
Journal: Hepatology (1995)

We investigated the secretory profiles of prostanoids in two types of nonparenchymal cell from the rat liver, sinusoidal endothelial cells and Kupffer cells, in primary culture both under basal conditions and after stimulation with adenine nucleotides. Prostaglandin (PG) E2 was the main prostanoid secreted by both types of hepatic nonparenchymal cell in the basal and adenosine triphosphate (ATP)-stimulated states. Time- and concentration-dependent effects of ATP-mediated PGE2 secretion were noted in sinusoidal endothelial cells, whereas the profile of the relative potencies of individual nucleotides was consistent with the presence of P2y and P1 purinergic receptors. In Kupffer cells, the regulation of prostanoid secretion by adenine nucleotides was essentially the same as that in sinusoidal endothelial cells except that adenosine did not stimulate prostanoid secretion and that prostanoid secretion differed somewhat; Kupffer cells secreted relatively more PGF2α and less 6-keto-PGF1α than sinusoidal endothelial cells in the presence of ATP, suggesting the presence of only P2y receptors. In summary, PGE2 is the main prostanoid secreted by hepatic nonparenchymal cells and its secretion may be stimulated by adenine nucleotides and adenosine.
Assessment of 1,3-Butadiene Epidemiology Studies
Authors: M. Gerald Ott
Journal: Environmental Health Perspectives (1990)

Positive carcinogenicity studies in mice and rats have led to concerns that 1,3-butadiene may be carcinogenic in humans under exposure conditions that have existed in occupational settings and perhaps exist today. The principal settings of interest are the styrene-butadiene rubber (SBR) manufacturing industry, which uses large quantities of 1,3-butadiene, and the 1,3-butadiene monomer industry. The potential for 1,3-butadiene exposure is highest during monomer transfer operations and is lowest in finishing areas of polymerization plants where the polymer products are processed. Three large cohort mortality studies have been conducted in the SBR and monomer producing industries since 1980. These studies, which examined the mortality experience of over 17,000 men employed in one monomer and 10 SBR facilities, are the subject of this review. All but one of the facilities began operations during the early 1940s. The mortality experience observed within these employee cohorts is comparable to that seen in other long-term studies of men employed in the petroleum, chemical, and rubber industries for all causes of death, total malignant neoplasms, and for the specific cancers seen in excess in the toxicologic studies. This paper discusses discrepant findings observed in more detailed analyses within individual cohorts and among employment subgroups, as well as selected limitations of the particular studies. Additional efforts to refine 1,3-butadiene exposure categories are needed. Within the context of sample size limitations inherent in these studies, there is currently inadequate evidence to establish a relationship between cancer mortality outcomes and 1.3-butadiene exposure in humans.
Pathological and Practical Researches on the Various Forms of Paralysis
Authors: E. Meryon
Journal: BMJ (1863)

form of clusters; and, further, their occasional disap- pearance under an attack of inflammation and suppura- tion.These latter characters remind us of the small tumours caused by hypertrophy of the sebiparous glands, and which are distinguished by the name of molluscum simplex.And, as a further illustration of the relation of acrochordon to molluscum, it may be mentioned, that it is no uncommon thing to see a tubercle of molluscum simplex converted by the expulsion of the hypertrophied gland into a mere pendulous bag of integument.The thymium appears to be nothing more than the fibrous wart so commnon on the bands; while the myrinecia is a broader, deeper, and less prominent variety of the same wart, occurring in the palms of the lhands and soles of the feet.I have seen myrmecia chiefly in the thick cuticle of the heel, where it is extremely painful and troublesome.It may be worth while to remember the recommendation of Celsus to treat it by the applica- tion of a boiled fig.To be continued.]
Current Concepts in Digitalis Therapy
Authors: Bernard Lown, Samuel A. Levine
Journal: New England Journal of Medicine (1954)

THE use of digitalis marks the beginning of the modern era of cardiac therapy. Whole-leaf digitalis and the purified derivatives, the cardiac glycosides, continue as the most effective medicinal agents in the management of patients with congestive heart failure. The loss of cardiac reserve manifested by failure is the result of an imbalance between cardiac muscle strength and the work load imposed on the heart. Therapy is therefore directed toward improving the function of the failing heart muscle and reducing the work load on the myocardium. The two are intertwined; affecting one influences the other. Since the ultimate event in . . .
Delay in Diagnosis of Slipped Upper Femoral Epiphysis
Authors: S Ankarath, A B Y Ng, P V Giannoudis, B W Scott
Journal: Journal of the Royal Society of Medicine (2002)

Treatment of slipped upper femoral epiphysis (SUFE) is directed at preventing progressive slippage, minimizing deformity and avoiding avascular necrosis and chondrolysis. Delay in treatment adversely affects long-term outcomes. In a retrospective study we assessed delays between symptom onset and evaluation of the patient in an orthopaedic department. 27 patients aged 10-16 years were grouped by source of referral (general practitioner or accident and emergency department), and hips were classified as stable or unstable according to ability to bear weight. The 27 children had 37 affected hips, 31 stable and 6 unstable. In the 20 patients referred by general practitioners, mean delay from symptom onset to orthopaedic evaluation was 119 days (range 2-504); in the 7 referred from accident and emergency departments it was 95 days (1-482). In the latter group the slips were more likely to be acute and unstable. 9 (45%) of the patients in the general-practitioner group had hip radiography before referral, all correctly diagnosed though not all the examinations included the recommended frog-lateral views. Long delays between onset and diagnosis of SUFE are most likely in patients with mild symptoms, able to bear weight on the hip. Any adolescent with undiagnosed hip or knee pain that has lasted more than a week should undergo radiological investigation of the hip, with frog-lateral as well as anteroposterior views.