tbuckley/cabot-search huggingface dataset:
OC-052 5 year follow up of a nurse led guided self management programme in ibd
Authors: C Stansfield, A Robinson, S Lal
Journal: Gut (2015)

<h3>Introduction</h3> Self management programmes are central to any long term strategy for managing chronic disease, the emphasis being to create expert patients who have the confidence, skills, information and knowledge to play a key role in their care and minimise the impact of the disease on their lives.<sup>1</sup>In addition, this has been shown to reduce attendance in outpatients and reliance upon the health care system.<sup>2</sup>The aim of the study was to monitor outcomes of a nurse led guided self management programme. <h3>Method</h3> A database of patients who had commenced self-management programme between January 2007 and January 2008 was created and maintained. Demographic data, diagnosis, colorectal cancer and osteoporosis surveillance, telephone helpline contacts, outpatient attendance and adverse events were evaluated. The database was maintained by a specialist nurse. Patients were contacted annually by the nurse via telephone to reassess for signs of relapse. Patient satisfaction with guided self-management as a method of follow up was evaluated by a questionnaire. <h3>Results</h3> 50 patients (36M: 14F) were included. Median ages 45 yrs (18–74 yrs). 32 patients had ulcerative colitis (16 pancolitis, 8 distal disease and 8 proctitis) and 18 Crohn’s disease (9 terminal ileal disease, 9 Crohn’s colitis The median time of period of remission 36 months (8 mths–10 yrs). Of the 50 patients, 10 patient had a significant flare of their IBD (8 Crohn’s disease, 2 colitis) and required them to exit the self-management programme due to disease progression. Median time to exit was 24 months (10–48). 2 required surgery, 6 progressed to immunomodulators and 2 to biologic therapy. Average clinic attendance for patients in remission (40 patients) was 1.9 hospital attendances within the five year period, with 2.9 appointments in primary care, all patients were treated with mesalazine and had annual blood tests. 26/33 patients with colitis required colorectal cancer surveillance, this was completed in 24/33 patients. All patients required a dexa scan in line with UK guidelines; this was completed in 75% of patients. Satisfaction with self-management remained high with 95% of patients scoring the method of follow up as good or excellent. <h3>Conclusion</h3> Therefore, self-management is a safe long term strategy for patients with IBD, but does require support from a specialist nurse to ensure colorectal cancer surveillance, osteoporosis screening completed and annual telephone review is made available. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Kennedy AP, Nelson E, Reeves D, <i>et al</i>. A randomised controlled trial to assess the effectiveness and cost of a patient orientated self management approach to chronic inflammatory bowel disease. Gut 2004;53(11):1639–1645 Robinson A, Thompson DG, Wilkin D, <i>et al</i>. Guided self-management and patient-directed follow-up of ulcerative colitis: a randomised trial. Lancet 2001;358(9286):976–981
Editorial
Authors: S.G.O. Johansson
Journal: Allergy (2001)

Dear Readers, I am very pleased to say that Allergy, European Journal of Allergy and Clinical Immunology, is in good shape and steadily growing in importance. The number of papers submitted to our journal in the year 2000 represented approximately a 10% increase over 1999. Thus, the group of Associate Editors and the Editorial Office have to work hard to select the best contributions for publication in order to avoid producing too voluminous and expensive a journal. Unfortunately, this means that we can accept only about every third paper. Since our journal is closely linked to our society, the EAACI, and the subscription is part of the membership, it is important that the journal contain material of interest to scientists, established specialists, and doctors in training. We have tried to respond to this need by publishing review articles and allergy review series, position statements, and original articles, as well as short communications and case reports. The AllergyNet section, introduced a few years ago, is increasingly popular as a quick way of communicating short reports. The impact factor of the journal is often discussed. Although this factor does not represent an indication of scientific quality, but rather indicates whether people read the articles, good or bad, it is a concern also for the Editorial Office of Allergy. Unfortunately, due to a misunderstanding by the Institute for Scientific Information, the non-peer-reviewed AllergyNet reports have been included in the impact factor calculations. Since the number of published articles is included in these calculations, regardless of their length, the large number of very short AllergyNet reports has had a negative effect on the impact factor. I am therefore pleased to announce that, from the year 2000, the AllergyNet reports will not be included in the calculations, a change which we expect will result in an increase of about 30% in the next impact factor for Allergy. However, the most important factor for Allergy is the opinion of our subscribers. The steady increase in papers submitted for publication is a good indication. However, please consider submitting even more of your best articles to Allergy. In addition to being listed in all the important databases and being available in the full text format on the Internet, Allergy also has, by far, the largest circulation in its field in Europe. S. G. O. Johansson, Editor-in-Chief
Patients with psoriasis have elevated levels of serum eosinophil cationic protein and increased numbers of EG2 positive eosinophils in the duodenal stroma
Authors: G. MICHAËLSSON, W. KRAAZ, B. GERDÉN, E. HAGFORSEN, I.P. LUNDIN, L. LÖÖF, O. SJÖBERG, A. SCHEYNIUS
Journal: British Journal of Dermatology (1996)
Beiträge zur Klassifizierung der Tumoren des Mundes und seiner Nebenorgane.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Ectopic secretion by tumours.
Journal: BMJ (1976)

respiratory failure.Triage may be a helpful concept to the relatively inexperienced, alerting them to what to do first when there are a number of demands being made simultaneously.Triage can be taught to casualty officers, but it can also be taught to the front-line staff-the ambulance men6 and nurses.Already ambulance men are taking proficiency certificates in resuscitation and intubation.Contrary to what many doctors may believe, it may be on these men and women that the responsibility lies for action-before the patient reaches casualty at all.The concept of triage in civilian practice should mean that no considerations whatever-of administration, of hierarchy, or even of the doctors' personal feelings-may be allowed to stand in the way of prompt recognition and immediate treatment of the patient at high risk.
Saccharin
Authors: S A Miller, V P Frattali
Journal: Diabetes Care (1989)

Saccharin, a nonnutritive sweetener discovered in 1879, has been the subject of controversy concerning its effect on public health on several occasions during this century. Over this period, the substance has come to be regarded as a useful commodity in the dietary management of diabetes mellitus. We review the historical and scientific background on the subject and propose a new approach in making public-health decisions on unique foods that serve a special dietary purpose.
Evaluation of a new antituberculous agent. Capreomycin sulfate (capastat sulfate)
Journal: JAMA (1973)

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Poor quality data are major obstacle to improving road safety, says World Bank
Journal: BMJ (2002)

Who should be primarily responsible for road safety on a national and international level?This is an important question.At present road safety is seen as everybody's responsibility and therefore nobody is being held accountable.Clearly, for a problem that globally causes about 1.2 million deaths and injures 10-15 million people a year, responsibilities should be assigned.Road safety is everybody's responsibility-the road users, governments, donor organisations, academia, and nongovernmental organisations.However, what is needed is a commission or agency in each country that will coordinate a multidisciplinary agenda, with clear roles for all, and ensure that this agenda is developed, implemented, and monitored.This
Present Concepts of Benign Breast Disease
Authors: Ira T. Nathanson
Journal: New England Journal of Medicine (1946)

Cysts, Hyperplasias and PapillomasThe greatest difficulty in interpretation and classification is encountered in lesions that exhibit cysts, hyperplasias or papillomatous formation. The lesions frequently coexist with or are superimposed on the abnormalities described above. Thus it can be seen that the opportunity to designate some lesions as distinct entities is relatively rare. It is probable that the various changes are manifestations of the same syndrome, but the evidence is not conclusive. The lesions usually occur in women in the latter part of active sexual life. Unlike the syndromes described above, regression following the menopause appears to be less frequent, . . .
COUNCIL ON MEDICAL SERVICE
Journal: JAMA (1953)

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The Biology of the Protozoa
Journal: JAMA (1934)

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Title: Clinical and Biological Evaluation of the Novel CD30/CD16A Tetravalent Bispecific Antibody (AFM13) in Relapsed or Refractory CD30-Positive Lymphoma with Cutaneous Presentation: A Biomarker Phase Ib/IIa Study (NCT03192202)
Authors: Ahmed Sawas, Pei-Hsuan Chen, Mikel Lipschitz, Scott Rodig, George Vlad
Journal: Blood (2020)
Fetal Surgery
Journal: JAMA (1999)

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Mr. Editor:
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rates of vertebral bone loss before and after liver transplantation in women with primary biliary cirrhosis
Authors: R Eastell
Journal: Hepatology (1991)

Atraumatic fractures caused by osteoporosis may be a serious complication of primary biliary cirrhosis. Mean (± S.D.) bone mineral density in the lumbar spine in 210 ambulatory women with primary biliary cirrhosis was 1.02 ± 0.19 gm/cm2, 7% lower than that in 139 age-matched normal women (after adjustment for age and body weight) (p < 0.001). Bone mineral density in the lumbar spine was inversely related to a risk score index of liver disease severity (r = −0.29, p < 0.001). The mean rate of bone loss in 105 of these 210 women was 2%/yr ± 4%/yr, twice as great as in the 139 normal women (p < 0.02). In 20 women with primary biiary cirrhosis followed up after orthotopic liver transplantation, bone mineral density in the lumbar spine decreased at 3 mo (p < 0.01), and this decrease may have resulted in atraumatic fractures in 13 of them. Bone mineral density in the lumbar spine then increased (p < 0.01) so that by 12 mo the median bone mineral density in the lumbar spine was similar to that before transplantation and by 24 mo it was 5% above it. Therefore we conclude that the progressive bone loss observed in primary biliary cirrhosis (which is further accentuated immediately after transplantation) may be halted, and the bone mass may be restored toward normal within 2 to 3 yr after orthotopic liver transplantation. (HEPATOLOGY 1991;14:296–300.)
Abstract 1751: The role of SIRT2 in BRCA1 regulation
Authors: Elizabeth Minten, Hui Zhang, Chunyang Li, PamelaSara Head, David S. Yu
Journal: Cancer Research (2019)

Abstract The most deleterious type of DNA damage a cell can sustain is the DNA double-stranded break (DSB). One of the major pathways responsible for the repair of DNA DSB breaks is the homologous recombination (HR) pathway, an error-free mechanism of repair that occurs primarily in the S and G2 phases of the cell cycle when a sister chromatid is available to be used as a repair template. Impairment of HR can result in genomic instability, which can increase the risk of tumorigenesis. However, many of the mechanisms by which defects in HR lead to an increased risk for developing cancer are unknown. Mutations or misregulation of the Breast Cancer 1 (BRCA1) protein, a major player in HR and an established tumor suppressor, have been linked to an increased lifetime risk for the development of cancer in both men and women, including colon, breast, ovarian, and pancreatic cancer. Yet, how BRCA1 is regulated in HR is not well understood and thus highlights a major a gap in our understanding of how deficiencies in HR contribute to the development of cancer. Our lab has discovered that the histone deacetylase and putative human tumor suppressor, SIRT2, has a crucial role in the repair of DNA DSBs. We have found that SIRT2 interacts with and deacetylates BRCA1, both in vitro and in cells, and that depletion of SIRT2 decreases BRCA1 protein levels, thus impairing HR. Our results show SIRT2 is a novel regulator of BRCA1 and is critical for the efficient repair of DNA DSBs through HR. These findings will provide invaluable insight into how to exploit the interplay between SIRT2 and BRCA1 as a novel therapeutic approach for the prevention and treatment of cancer. Citation Format: Elizabeth Minten, Hui Zhang, Chunyang Li, PamelaSara Head, David S. Yu. The role of SIRT2 in BRCA1 regulation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1751.
Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia
Authors: Huining Kang, I.-Ming Chen, Carla S. Wilson, Edward J. Bedrick, Richard C. Harvey, Susan R. Atlas, Meenakshi Devidas, Charles G. Mullighan, Xuefei Wang, Maurice Murphy, Kerem Ar, Walker Wharton, Michael J. Borowitz, W. Paul Bowman, Deepa Bhojwani, William L. Carroll, Bruce M. Camitta, Gregory H. Reaman, Malcolm A. Smith, James R. Downing, Stephen P. Hunger, Cheryl L. Willman
Journal: Blood (2009)