tbuckley/cabot-search huggingface dataset:
EPIDEMIOLOGY AND PROPHYLAXIS OF MALARIAL FEVER.
Journal: JAMA (1900)

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Medical and public health aspects of boxing
Authors: R. G. Morrison
Journal: JAMA (1986)

In recent years, an extensive medical literature has accumulated regarding the health hazards associated with boxing. As the evidence that boxing produces irreversible brain damage in boxers has become more compelling, physicians have begun to consider the larger issue of whether the sport is acceptable in its present form. This has resulted in a number of proclamations concerning boxing by various representatives of the medical community, which have both added information to and fueled the public debate over boxing. This article seeks to review the relevant medical literature concerning the health effects of boxing; to look at the contributions made in the last few years by the medical community to the public debate over boxing; and to suggest ways in which the objectives of the medical professional concerning boxing can best be achieved. (<i>JAMA</i>1986;255:2475-2480)
Beating MAZE procedure using an infrared coagulator: To heat to beat Hiroshi Kubota, Shinichi Takamoto, Katsuhide Maeda, Mikio Ninomiya, Katsuhito Ueno, Yutaka Kotsuka. Department of Cardiothoracic Surgery, Univ. of Tokyo, Tokyo, Japan
Journal: Journal of the American College of Cardiology (2001)
Multivariate Analysis of Cancer Mortalities for Selected Sites in 24 Countries
Authors: Haruo Yanai, Yutaka Inaba, Hirohumi Takagi, Shunichi Yamamoto
Journal: Environmental Health Perspectives (1979)

In order to analyze the pattern in the geographical distribution of cancer death in 24 countries of the world, correlation coefficients were calculated between pairs of mortality rates of different cancer sites, using the data for 13 sites in males and 14 sites in females over 18 years from 1950 to 1967. Then factor analysis by means of varimax method was performed on 13 x 13 correlation matrix for males, 14 x 14 correlation matrix for females and 27 x 27 correlation matrix for males and females combined. As a result of factor analysis, three factors are extracted, which are commonly recognized in both males and females. The first factor has high positive factor loadings on pancreas, prostate (for males), skin, and intestine cancers, and negative loadings on stomach and liver cancers. The second factor has high positive factor loading on rectum, intestine, and lung cancers, and the third factor on larynx, oral, and esophagus cancers. Factor analysis based on 27 x 27 correlation matrix revealed that the third factor of both sexes are heterogeneous with regards to the distributions of the factor score. In order that we may find some clues to develop an etiological hypothesis for each site of cancer, we obtained the correlation coefficient between the scores of the extracted factors and the variables on food and environmental agent, and performed stepwise regression methods as well. One of the most striking results we obtained was that excessive drinking of alcohol and the lack of appropriate intake of fruit are suspected as etiological promoters in the pathogenesis of oral, esophagus, and larynx cancers in males.
Megaloblastosis Produced by a Cytosine Antagonist 1-β-D Arabinofuranosylcytosine
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXTH-81. TARGETING Nrf2 ANTIOXIDATIVE PATHWAY AS A NOVEL THERAPEUTIC STRATEGY FOR IDH1-MUTATED CANCERS
Authors: Yang Liu, Yanxin Lu, Orieta Celiku, Aiguo Li, Chunzhang Yang
Journal: Neuro-Oncology (2018)

Mutations in isocitrate dehydrogenase (IDH1/2) are the most prevalent genetic abnormalities in lower grade glioma. Neomorphic enzyme activity of mutant IDH1/2 leads to the production of oncometabolite 2-hydroxyglutarate, accompanied with disruption of redox balance through aberrant NADP+/NADPH metabolism. The remarkable accumulation of reactive oxygen species (ROS) suggests distinctive metabolic stress and vulnerability in cancer cells, implying the potential for selective therapeutic approaches for IDH1-mutated malignancies. We investigated the ROS homeostasis in IDH1 mutation transduced cells as well as patient derived IDH1-mutated brain tumor initiating cells (BTIC). The importance of antioxidant genes was confirmed through COX regression analysis from a large cohort of IDH1-mutated lower grade glioma. Further, we investigated the involvement of Nrf2, the master transcriptional factor that regulates antioxidant enzymes in IDH1-mutated cells. Finally, we evaluated the therapeutic value of Nrf2 inhibitor in IDH1-mutated cancer in vitro and in vivo. We found that pathogenic IDH1 mutation leads to substantial reprogramming in ROS homeostasis, highlighted that this prompted ROS generation and compensatory up-regulation of ROS scavenging genes. The expression of key ROS scavenging genes not only establishes resistance for cancer cells, but also predicts poor disease outcome in IDH1-mutated lower grade glioma. Further, IDH1-mutated glioma develop dependency on Nrf2-governed antioxidant pathway, which plays a key role in modulating glutamate/glutathione metabolism, ROS detoxification and cancer cell survival. Pharmacologic targeting of Nrf2 not only led to ROS-derived cytotoxicity in IDH1-mutated cells, but also selectively suppressed IDH1-mutated xenograft growth in vivo. Our findings showed that Nrf2 antioxidant pathway plays a central role in the biology of IDH1-mutated glioma. Targeting Nrf2 antioxidant pathway showed promising tumor suppressing effect, suggesting novel therapeutic approaches for IDH1-mutated malignancies.
Tumor necrosis factor-induced, superoxide-mediated neutrophil accumulation in cold ischemic/reperfused rat liver
Authors: H Shibuya, N Ohkohchi, S Tsukamoto, S Satomi
Journal: Hepatology (1997)

The mechanisms of hepatic ischemia/reperfusion injury are complicated and multifactorial. This study was designed to examine superoxide generation and neutrophil accumulation in cold ischemic-reperfused rat livers after elimination of Kupffer cells and to determine the role of superoxide/tumor necrosis factor (TNF) interactions. Rat Kupffer cells were eliminated by liposome-encapsulated dichloromethylene diphosphonate injected intravenously. Livers from control and treated rats were isolated and preserved in University of Wisconsin solution (4°C) for 0, 12, and 24 hours and then perfused for 60 minutes with oxygenated Krebs-Henseleit bicarbonate buffer (37°C) by adding neutrophils into the perfusate. Superoxide generation was measured by using real-time chemiluminescence (CL) during perfusion, and neutrophil accumulation was assessed by measuring myeloperoxidase activity in the liver tissue. In the control livers, CL intensity markedly increased on reoxygenation, and after neutrophil infusion it increased again with a lag period of 10 minutes. Total CL intensity and myeloperoxidase activity increased with the duration of cold preservation. TNF release into the effluent perfusate was detectable only after 24 hours of preservation, and lactate dehydrogenase release was high. Elimination of Kupffer cells attenuated CL intensity and TNF and lactate dehydrogenase release and resulted in reduced myeloperoxidase activity. Electron microscopy revealed amelioration of hepatocyte swelling and endothelial cell disruption when Kupffer cells were eliminated. After 24 hours of preservation, superoxide generation was inhibited in the control livers by anti-TNF antiserum, whereas TNF release was not inhibited by superoxide dismutase. These results suggest that TNF induces superoxide generation by Kupffer cells, which mediates neutrophil accumulation and causes cellular injury in the initial phase of reperfusion.
Textbook of Surgery
Authors: John H. Wulsin
Journal: JAMA (1970)

And now edition number nine—a respectable number that qualifies this work for a secure place among the sacred books of medical students. Owners of editions one through eight will wonder, shall we add to our wisdom by investing in number nine? And what will lure strangers to this text? This time a paperback, on the order of a telephone book but smaller, and yet too large for a bulging coat pocket. This is the style of the 70s—cloaking established knowledge in the unassuming garb of the airport book mart; less forbidding, no doubt; lighter; we hope cheaper; and probably more profitable to publisher. If students no longer graduate in cap and gown, why should their texts wear formal clothes? For this new edition previous contributors have dressed up their proven chapters by adding some contemporary dash. In some instances chapters have been rewritten by either old or new contributors. The
RESEARCH IN PROGRESS
Journal: Circulation Research (1954)

Male rats averaging 220 Gm. were adrenalectomized or injected with cortisone (6 mg.daily) or lipoadrenal extract (10 Glycogen Units daily) for 18 days.Female rats averaging 160 Gm. were thyroidectomized or injected with thyroxine (130 Aig.daily) for the same number of days.At the end of this period, all animals were injected with 12.5 mg.per kilogram heparin and killed one hour later.Plasma from these heparinized donors was then mixed with lipemic serum from other rats which had been given orally 6 ml.maize oil, two hours prior to sacrifice.The turbidity of the mixtures was determined immediately and 5, 15, 30 and 60 minutes after mixing, in a colorimeter.For comparison, similar turbidity determinations were made on mixtures of plasma from untreated (control) heparinized rats with lipemic serum.
How to Reduce Mortality in Hemodialysis Patients Still a Puzzle
Authors: M. Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increasing rates of depression
Authors: G. L. Klerman
Journal: JAMA (1989)

Several recent, large epidemiologic and family studies suggest important temporal changes in the rates of major depression: an increase in the rates in the cohorts born after World War II; a decrease in the age of onset with an increase in the late teenaged and early adult years; an increase between 1960 and 1975 in the rates of depression for all ages; a persistent gender effect, with the risk of depression consistently two to three times higher among women than men across all adult ages; a persistent family effect, with the risk about two to three times higher in first-degree relatives as compared with controls; and the suggestion of a narrowing of the differential risk to men and women due to a greater increase in risk of depression among young men. These trends, drawn from studies using comparable methods and modern diagnostic criteria, are evident in the United States, Sweden, Germany, Canada, and New Zealand, but not in comparable studies conducted in Korea and Puerto Rico and of MexicanAmericans living in the United States. These cohort changes cannot be fully attributed to artifacts of reporting, recall, mortality, or labeling and have implications for understanding the etiology of depression and for clinical practice. (<i>JAMA</i>. 1989;261:2229-2235)
244. High-Capacity Adenovirus Vector-Mediated Transfer of Conditional Cytotoxic Herpes Simplex Type 1-Thymidine Kinase [HSV1-TK] and Immunostimulatory Fms-Like Tyrosine Kinase 3 Ligand [Flt3L] Transgenes Elicits Immune-Mediated Long-Term Survival in a Syngeneic Intracranial GBM Model
Journal: Molecular Therapy (2009)
Low Back Pain
Authors: Richard A. Deyo, James N. Weinstein
Journal: New England Journal of Medicine (2001)

About two thirds of adults suffer from low back pain at some time. Low back pain is second to upper respiratory problems as a symptom-related reason for visits to a physician.1,2 There are wide variations in care, a fact that suggests there is professional uncertainty about the optimal approach.3,4 In addition, there is evidence of excessive imaging and surgery for low back pain in the United States,58 and many experts believe the problem has been "overmedicalized."911 In recent years, magnetic resonance imaging (MRI) has come to be widely used, the roles of exercise and bed rest . . .
All this sewering and watering
Authors: Richard Smith, Jane Smith, Fiona Godlee, Jacqui Wise, Linda Beecham, Sandra Goldbeck-Wood, Alison Tonks General, Trish Groves, Luisa Dillner, Tessa Richards, Liz Crossan, Stephen Lock, Linda Reviews, Kamran Abbasi, Douglas Carnall, Gaby Shockley, Margaret Benfell, Andrew Woodward, John Gary, Bryan Standing, Richard Harling, Susan Minns, Marita Batten Picture, Jan Science, Abi Berger, Margaret Cooter, Jackie Annis, Greg Cotton, Sharon Davies, Miriam Pinchuk, Julia Thompson, Tony Delamothe, Christopher Martyn, Roger Robinson, Tony Smith, Gwen Adshead, James Barrett, Nicky Britten, Angela Coulter, Teifion Davies, Robin Ferner, Ian Forgacs, Trish Greenhalgh, Marcia Hall, Iona Heath, Richard Hobbs, David Jewell, Kevin Jones, Duncan Keeley, Tim Lancaster, Ben Lloyd, Diana Lockwood, Azeem Majeed, Michael O'brien, John Rees, Nicholas Steel, Sheila Teasdale, Tom Treasure, Chris Van Weel, John Williams, Jeremy Wyatt, Doug Altman, Mike Campbell, Tim Cole, Jon Deeks, Stephen Evans, David Machin, Ken Macrae, Julie Morris, Jackie Connor, Andy Josephides, Bernadette Kearney, Catherine Harding, Nick Supple, Simon Walker, David Evans, Jennifer Leaning, Rajendra Kale, George Alberti, Jeremy Anderson, Tony Culyer, Alba Dicenso, Canada Dixon, Paul Glasziou, Heather Australia, Peter Goodare, Tony Denmark, Brian Grabham, Canada Haynes, Canada Kjellstrand, Christian Knottnerus, Cindy Austria, Hong Lam, Alessandro Kong, Dennis Liberati, David Mant, U Jean, Claude Mbanya, Indraneel Cameroon, India Mittra, David Mulrow, Canada Naylor, John Roberts, Paula Rochon, Canada Savill, Jaime Sepulveda, Fiona Stanley, Tessa Australia
Journal: BMJ (1998)
INSULIN REACTIONS AND HYPOGLYCEMIA
Journal: JAMA (1928)

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Patient Satisfaction as a Possible Indicator of Quality Surgical Care—Reply
Authors: Heather Lyu, Michol Cooper, Julie A. Freischlag, Martin A. Makary
Journal: JAMA Surgery (2013)

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Pulmonary Arteriovenous Fistulectomy: Simplified Technique
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A nonsteroidal anti-inflammatory agent. Indomethacin (indocin)
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reference Directories
Journal: JAMA (1991)

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