tbuckley/cabot-search huggingface dataset:
Predictors of Thromboembolism in Atrial Fibrillation: I. Clinical Features of Patients at Risk
Journal: Annals of Internal Medicine (1992)

Objective: To identify those patients with nonrheumatic atrial fibrillation who are at high risk and those at low risk for arterial thromboembolism. Design: Cohort study of patients assigned to placebo in a randomized clinical trial. Setting: Five hundred sixty-eight inpatients and outpatients with nonrheumatic atrial fibrillation assigned to placebo therapy at 15 U.S. medical centers from 1987 to 1989 in the Stroke Prevention in Atrial Fibrillation study. Patients were followed for a mean of 1.3 years. Measurements: Clinical variables were assessed at study entry and correlated with subsequent ischemic stroke and systemic embolism by multivariate analysis. Main Results: Recent (within 3 months) congestive heart failure, a history of hypertension, and previous arterial thromboembolism were each significantly and independently associated with a substantial risk for thromboembolism (> 7% per year; P ≤ 0.05). The presence of these three independent clinical predictors (recent congestive heart failure, history of hypertension, previous thromboembolism) defined patients with rates of thromboembolism of 2.5% per year (no risk factors), 7.2% per year (one risk factor), and 17.6% per year (two or three risk factors). Nondiabetic patients without these risk factors, comprising 38% of the cohort, had a low risk for thromboembolism (1.4% per year; 95% Cl, 0.05% to 3.7%). Patients without clinical risk factors who were under 60 years of age had no thromboembolic events. Conclusion: Patients with atrial fibrillation at high risk (> 7% per year) and low risk (< 3% per year) for thromboembolism can be identified by readily available clinical variables.
Posttraumatic Stress Disorder and Depression in Battle-Injured Soldiers
Authors: Thomas Grieger
Journal: American Journal of Psychiatry (2006)

Objective: This study examined rates, predictors, and course of probable posttraumatic stress disorder (PTSD) and depression among seriously injured soldiers during and following hospitalization. Method: The patients were 613 U.S. soldiers hospitalized following serious combat injury. Standardized screening instruments were administered 1, 4, and 7 months following injury; 243 soldiers completed all three assessments. Cross-sectional and longitudinal analyses of risk factors were performed. PTSD was assessed with the PTSD Checklist; depression was assessed with the Patient Health Questionnaire. Combat exposure, deployment length, and severity of physical problems were also assessed. Results: At 1 month, 4.2% of the soldiers had probable PTSD and 4.4% had depression; at 4 months, 12.2% had PTSD and 8.9% had depression; at 7 months, 12.0% had PTSD and 9.3% had depression. In the longitudinal cohort, 78.8% of those positive for PTSD or depression at 7 months screened negative for both conditions at 1 month. High levels of physical problems at 1 month were significantly predictive of PTSD (odds ratio=9.1) and depression at 7 months (odds ratio=5.7) when the analysis controlled for demographic variables, combat exposure, and duration of deployment. Physical problem severity at 1 month was also associated with PTSD and depression severity at 7 months after control for 1-month PTSD and depression severity, demographic variables, combat exposure, and deployment length. Conclusions: Early severity of physical problems was strongly associated with later PTSD or depression. The majority of soldiers with PTSD or depression at 7 months did not meet criteria for either condition at 1 month.
Third Terry Fox Cancer Conference on Cancer Prevention: Theory and Practice
Journal: JNCI Journal of the National Cancer Institute (1985)

Third Terry Fox Cancer Conference on Cancer Prevention: Theory and Practice Get access JNCI: Journal of the National Cancer Institute, Volume 74, Issue 3, March 1985, Page 733, https://doi.org/10.1093/jnci/74.3.733-b Published: 01 March 1985
In Comment...
Authors: Robert J. Levine
Journal: JAMA (1975)

THE COMMENTARY in this issue (p 257) by Irvine Page, MD, provoked in me a variety of reactions, including (1) agreement with his feeling that what we need most to guide us in conducting research involving human subjects is wisdom and common sense; (2) sympathy with his frustration in attempting to define "wisdom," "common sense," and "informed consent"; (3) disagreement with some of the assumptions implicitly or explicitly contained in his assessment of the role-relationships, responsibilities, and prerogatives of the public, the government, patients, subjects, physicians, investigators, and various professional or academic organizations; and (4) defensiveness (as a present or past member of all groups mentioned in category 3). I shall elaborate some of these reactions further. <h3>The Investigator's Risk</h3> Some physicians assume that investigators take considerable personal risk when they conduct experiments on patients. Thus, we might wonder what personal risk was assumed by Florey when he injected his
Streptococcal sepsis.
Journal: BMJ (1970)

Streptococcal SepsisThyrotoxicosis: Aberdeen study shows high incidence of thyroid dysfunction in patients treated by subtotal thyroidectomy for thyrotoxicosis.Life-long follow-up is con- sidered "obligatory" (p. 519).Description of automated register for follow-up at p. 556.Leader at p. 516.Prenatal Sex Prediction: Found to be 870 accu- rate on samples of amniotic fluid obtained by amniocentesis.Between 13th and 16th week of pregnancy considered optimum time for inves- tigation (p. 523).Dermatitis and Enzyme Detergents: Twelve cases developing in women employed in Not- tingham home-help service (p. 537).Leader at p. 518.Other Clinical Studies: Paracervical nerve block (p.526); plasma magnesium in primary hyper- parathyroidism (p. 529); practolol in supraven- tricular cardiac dysrhythmias (p. 533); plasma insulin after removal of insulinomas (p. 535); thrombocytopenia and carcinoma (p.540); portal hypertension (p. 544); and amniotic fluid embolism (p.545).Immunotherapy of Cancer: Possible valuable role of Corynebacterium parvum suggested from studies on murine fibrosarcomas (p.541).Letter on B. pertussis vaccine in leukaemia and lymphoma (p.565).
Physicians continue to study cause(s) of `bubble' boy's death
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;italic&gt;Indicators&lt;/italic&gt; and &lt;italic&gt;Trends&lt;/italic&gt;
Journal: JNCI Journal of the National Cancer Institute (1963)

Journal Article Indicators and Trends Get access JNCI: Journal of the National Cancer Institute, Volume 30, Issue 4, April 1963, Page 845, https://doi.org/10.1093/jnci/30.4.845-a Published: 01 April 1963
Nutrition
Authors: Max Millman
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The initiation of a new series of articles on nutritional topics (224:1521, 1973) augurs well for our profession and the health of the public. Any program that promises to disseminate nutritional knowledge, to stimulate interest in it, or, to quote Dr. White, "... to whet the appetite of the reader to want to know a little more" is indeed worthwhile. For many years the subject of nutrition has been the stepchild of clinical medicine. Not only is it slighted in medical schools but also in continuing medical education. Postgraduate courses in nutrition for the practicing physician are scarce, and the pages devoted to it in clinical journals is infinitesimal. A survey of the<i>Archives of Internal Medicine</i>and the<i>Annals of Internal Medicine</i>shows that of a combined total of 282 original articles published in 1972, only three dealt meaningfully with nutrition. It is sincerely hoped that the
Aequanimitas
Authors: Glenn Feole
Journal: JAMA (1987)

I have seen joy and I have seen death and I have fought the fight with this double-edged sword called Pediatrics And twice I have seen you, my daughter, on the edge and have grabbed you with the fierceness and concentration of the drowning. Aequanimitas, Sir William, vanished but quietly returned as we slowly walked home surrounded by the green, wet peace of the fading storm. The warmth of the golden sun on your yellow hair blue skies umbrellaed over us, reflected in your eyes as you smile up at me asking questions, gently, patiently, eagerly. A mouse is dead, you tell me... do you want to see? insistently pointing to the dark gray body hiding in the shadows of the garage. so we'll bury it this doesn't really hurt since being dead is like being asleep I shove the blade in with more force than I need and it
Danse macabre
Authors: S. Vaisrub
Journal: JAMA (1980)

Medical involvement with suicide is recent. When Pliny the Elder opined, "Amid the miseries of our life on earth, suicide is God's best gift to man," he did not envision the intervention of a physician. Nor did Nietzsche, centuries later, when he mused, "The thought of suicide is a great consolation; by means of it one gets successfully through many a bad night." And certainly the physician was far removed from his mind when Albert Camus stated, "There is but one serious philosophical problem, and that is suicide." The physician entered the suicide scene when psychiatrists began to gain insights into the psyche of candidates for self-destruction. Freud held that suicide is a form of aggression against a loved person that has turned on the self, a triumph of the "death wish." Meninger viewed suicide as an amalgam of the wish to die—to kill and to be killed. Without probing
Typographical Errors in the Table
Authors: Carrie Colla, Valerie Lewis, Lee-Sien Kao, Ba James O'malley, Chiang-Hua Chang, Elliott Fisher, O Kao, O Lewis
Journal: JAMA Internal Medicine (2017)

There is no reduction in skilled nursing facility spending in the overall Medicare cohort.• In both cohorts, there is now a small but statistically significant increase in 30-day readmissions.• Spending did not vary monotonically with length of ACO implementation.• The difference between mean spending in the ACO group and the control group is larger.Thus, we have requested that our article be retracted and replaced with the correct data and findings.The replacement article has corrected data and information in the abstract, text, Tables, Figures, and eFigures in the online supplement.We regret any confusion the errors in the CMS data may have caused the readers and editors of JAMA Internal Medicine.The abstract, text, Tables, Figures, and eFigures in the original article have been corrected and replaced online.
Recall
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolic and therapeutic effects of hydroxyurea in chronic myeloid leukemia
Authors: B. J. Kennedy
Journal: JAMA (1966)

Hydroxyurea (Hydrea) is a compound currently employed in clinical trials in malignant disease. It has produced bone marrow suppression, megaloblastosis, and antitumor effects in animals and man. Hydroxyurea was first synthesized by Dresler and Stein in 1869.<sup>1</sup>Its empirical formula is CH<sup>4</sup>N<sup>2</sup>O<sup>2</sup>and its structural formula is shown in Fig 1. Hydroxyurea was employed in biological studies in 1928 by Rosenthal and co-workers who demonstratedthe development of anemia and megaloblastosis in rabbits during treatment with large doses. They also observed a depression of leukocyte formation in the bone marrow (Table 1).<sup>2</sup>Further biological studies were reported in 1958,<sup>3</sup>and in 1960 antitumor activity was reported in animal screening studies.<sup>4</sup> Hydroxyurea has antitumor activity against transplantable L1210 leukemia in mice and against L1210 strains that were resistant to methotrexate (Amethopterin), 2-amino-6-purinethiol or 8-aza-guanine. It was also active against the solid tumor
Thoracic splenosis.
Authors: S Madjar, D Weissberg
Journal: Thorax (1994)

BACKGROUND--Thoracic splenosis is an uncommon side effect of thoracoabdominal trauma involving injury to the diaphragm and spleen. Only 20 patients with a similar problem have been reported previously. METHODS--Two patients with thoracic splenosis were studied. RESULTS--One of the patients had undergone thoracotomy for resection of a "pulmonary nodule". The other remains under observation. CONCLUSION--Presence of a pulmonary nodule in a patient with history of injury to the diaphragm and spleen should arouse suspicion of splenosis. Appropriate investigation may prevent an unnecessary and potentially harmful operation.
National Drunk and Drugged Driving Prevention Month—December 1995
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of clinical and economic prognoses from Medicare claims data
Authors: G. Anderson
Journal: JAMA (1990)

Using a 5% nationally random sample of Medicare beneficiaries, we calculated the probability of dying, the probability of being readmitted, and the mean level of inpatient hospital expenditures within various time periods following discharge for those beneficiaries who were discharged alive from an acute-care hospital during 1983. We then examined the 674 most common principal discharge diagnoses and found significant variations by diagnosis code for all three out-comes. We believe that analyses of claims data by diagnosis code can provide useful information to clinicians and their patients regarding the clinical and economic prognosis of specific diseases, help managed-care programs identify patients likely to incur substantial costs over a several-year period, and inform insurers regarding the expected level of resources that will be used following discharge for patients with specific diseases. (<i>JAMA</i>. 1990;263:967-972)
P1.04-69 Modelling the Immunosuppressive Difference of SBRT and CRT by Simulating the Dose to Circulating Lymphocytes in Non-Small Cell Lung Cancer
Authors: Y. Shen, Y. Meng, X. Tang, P. Gu, C. Yu, W. Wang, F. Kong, H. Yang
Journal: Journal of Thoracic Oncology (2019)
Abstract 104: Elevated Serum Cortisol Levels As A Risk Factor For Developing Coronary Artery Abnormalities In Kawasaki Disease
Authors: Rina Toyoda, Shinichi Takatsuki, Keiko Aso, Mari Sato, Tsutomu Saji
Journal: Circulation (2015)

Background and objectives: Endogenous cortisol (CRS) increases in a variety of inflammatory diseases and vasculitis syndrome, and recognized as a one of risk factors of disease progression. Although only one previous study reported that CRS level is elevated in acute Kawasaki disease (KD), the predictive value of CRS in KD has not been fully investigated. The aim of this study is to evaluate whether serum CRS levels can predict initial treatment response and development of coronary artery abnormalities (CAAs) in the acute phase of KD. Materials and Methods: A retrospective study was designed to evaluate serum CRS levels in 92 children with acute KD who were admitted between December 2011 and May 2014. The subjects consisted of 46 males and 46 females aged from 1 month to 12 years (median, 2 years). Serum CRS levels were measured before the initial treatment of IVIG. With Kobayashi score for predicting IVIG resistance, patients were divided into high (Kobayashi Score≧5) and low risk (Kobayashi Score &lt;5) group. Coronary artery diameter was measured at weeks 1, 2, 4 and we calculated maximum Z-score. CAAs were defined as equal to greater than 2.5 of Z-score. Results: Serum CRS level was 32.7μg/dl (median, 6.2 to 139μg/dl) which is higher than healthy children (5 to 25μg/dl), and significantly elevated in high risk group (median, 41.3μg/dl ) than those in low risk group (median, 27.1μg/dl, p=0.003). In patients with CAAs CRS level was higher than those without CAAs (Z&lt;2.5 vs Z≧2.5, median 30.4 vs 37.3μg/dl, p=0.052). Additionally, 1 patient who had maximum cortisol level (139μg/dl) showed CAAs (Z-score, seg1: 9.1, seg5: 10.2 at week 4). CRP, WBC counts, and albumin level had no significant correlation with CRS. Conclusions: We conclude that serum CRS before IVIG were significantly higher in patients with high risk group. CRS may be a potential predictor for developing CAAs.
Herpes Zoster
Authors: S. Harvey Sklar
Journal: JAMA (1985)

Thirty-two adults were enrolled in a randomized, placebo-controlled double-blind trial of intramuscular injections of gel-sustained adenosine monophosphate (AMP) given three times a week for up to four weeks for acute herpes zoster. Adenosine monophosphate moderately reduced the pain soon after the start of treatment, decreased desquamation time, and promoted faster healing of the skin than placebo treatment. Adenosine monophosphate treatment reduced virus shedding and cleared the virus faster than in placebo-treated subjects. At the end of the initial four-week treatment period, 88% of AMP-treated patients were pain free, as opposed to only 43% in the placebo group. After four weeks, all patients who had not recovered from pain started receiving AMP treatment without breaking the code. All these patients recovered from pain within three weeks after initiation of treatment. No recurrence of pain or lesions was experienced from three to 18 months after the end of treatment. Adenosine monophosphate, a natural cellular metabolite, showed no side effects or toxicity during and after the treatment. (<i>JAMA</i>1985;253:1427-1430)
Frequent Genomic Alterations in Epithelium Measured by Microsatellite Instability Following Allogeneic Hematopoietic Cell Transplantation in Humans.
Authors: Alexandros Spyridonidis, Philipp Faber, Paul Fisch, Miguel Waterhouse, Annette Schmitt-Graeff, Hartmut Bertz, Juergen Finke
Journal: Blood (2005)
Error in Methods and in Figure Axis
Authors: Nikolaos Koutsouleris, Rachel Upthegrove, Stephen Wood
Journal: JAMA Psychiatry (2019)

Qiang Wang, MD, PhD; Hei Man Wu, PhD; Weihua Yue, MD, PhD; Hao Yan, PhD; Yamin Zhang, BM; Liwen Tan, MD; Wei Deng, MD; Qi Chen, MD; Guigang Yang, MD; Tianlan Lu, MD; Lifang Wang, MD; Fuquan Zhang, MD; Jianli Yang, MD; Keqing Li, MD; Luxian Lv, MD; Qingrong Tan, MD; Hongyan Zhang, MD; Xin Ma, MD, PhD; Fude Yang, MD; Lingjiang Li, MD, PhD; Chuanyue Wang, MD, PhD; Xiaohong Ma, MD; Liansheng Zhao, PhD; Hongyan Ren, MD; Hao Yu, PhD; Yingcheng Wang, PhD; Xun Hu, PhD; Dai Zhang, MD, PhD; Pak Sham, PhD; Tao Li, MD, PhD; for the Chinese Antipsychotics Pharmacogenomics Consortium
CARDIAC STIMULANTS.
Authors: JOSEPH M. PATTON
Journal: JAMA (1903)

crease or decrease the functions of those parts.We can depress the functions of the motor nerve endings with conin, and the sensory nerve endings with aconite.We can paralyze the involuntary muscle fibers directly with the nitrites, or indirectly by chloral hydrate, which de¬ presses the functions of the vasomotor center.We can stimulate or depress the functions of cardiac muscle and dilate or contract the blood vessels.The tissues of