tbuckley/cabot-search huggingface dataset:
CLASSIFICATION OF CHEMICAL SALTS AND COMPOUNDS AS PREPARATIONS OF COAL TAR.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Chemistry of Chromium and Some Resulting Analytical Problems
Authors: Saul I. Shupack
Journal: Environmental Health Perspectives (1991)

Chromium, named for its many-colored compounds, exists in the oxidation states of -2 to +6 inclusively. The compounds exhibit a wide range of geometries including square planar, tetrahedral, octahedral, and various distorted geometries. Chromium is found in nature principally as the chromite ore FeCr2O4 in which chromium is in the +3 state. The existence of a particular oxidation state is dependent on many factors including pH, redox potentials, and kinetics. Thermodynamically, +3 and +2 are the most stable states, while the +3 and +6 oxidation states are the most common ones found in aqueous solution. Kinetically, chromium +3 is substitutionally inert: for water exchange k(sec-1) = 2.5 x 10(-6), due to the presence of the half-filled d(t2g)3.4A2g state. On the other hand, protonation/deprotonation is quite rapid. Polymerization is very slow but is promoted at higher pHs; acid cleavage of the protonated oligomers is also quite slow. Chromium +6 as the chromate ion is strongly oxidizing at low pHs and less so in basic solution. The chromate ion does form some polyacids and polyanions. These factors must be considered in analyzing samples for total chromium and for the amounts of each oxidation state.
VIII. The Movements of the Eyes in Reading.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lower Esophageal Ring
Authors: Raj K. Goyal, John J. Glancy, Howard M. Spiro
Journal: New England Journal of Medicine (1970)

Associated DiseasesHiatal HerniaIt is generally held that hiatal hernia is an integral part of the mucosal ring and that the presence of a ring constitutes definite evidence of hiatus hernia.3,10,57, 67 Since most mucosal rings are located at the squamocolumnar junction, and the rings are always seen well above the diaphragmatic shadow, MacMahon et al.21 argued that hiatal hernia is always associated with a ring. However, this conclusion assumes that the squamocolumnar junction corresponds to the junction of the stomach and esophagus. There is evidence to suggest that this may not be so.29,30, 68 In proved cases of hiatal hernias, . . .
生育因素和黑色素瘤的风险
Authors: N.C. Støer, E. Botteri, R. Ghiasvand, M. Busund, S. Vangen, E. Lund, M.B. Veierød, E. Weiderpass
Journal: British Journal of Dermatology (2019)

黑色素瘤是最严重的皮肤癌,2012年,在世界范围内其导致232,000例新发癌症病例及55,000例死亡。黑色素瘤最重要的风险因素是日光紫外线辐射、室内日光浴、皮肤白皙、有许多痣(色素痣)和雀斑、浅色头发及皮肤日晒反应。女性性激素(如雌激素和孕激素)也表明对黑色素瘤的出现有作用,这是因为黑色素瘤在女性中绝经期前较男性更常见,然而在绝经期后恰恰相反。研究激素与出现黑色素瘤的风险的相关性的一种方法是研究与女性生育史相关的因素,即所谓的生育因素,例如,初潮年龄(第一次月经来潮)、月经周期、绝经年龄及从初潮到绝经的时间、子女人数、首次和末次生育年龄及哺乳总时长。在挪威女性与癌症(NOWAC)研究中,作者研究了生育因素与黑色素瘤风险的总体、身体局部和黑色素瘤亚型方面的相关性。NOWAC成立于1991年,截至2015年底,包括全国约170,000名接受黑色素瘤诊断随访的女性。在随访期间,1,347例黑色素瘤病例被确诊。在此大型队列中,作者未发现确凿的证据表明生育因素与黑色素瘤风险总体相关。但他们发现初潮与绝经间期较长者亚型浅表扩散性黑色素瘤的风险增加。
Potential hazard of serotonin syndrome associated with dexfenfluramine hydrochloride (Redux)
Authors: C. H. Schenck
Journal: JAMA (1996)

<h3>In Reply.</h3> —The letter from Drs Schenck and Mahowald that discusses the potential for serotonin syndrome when using dexfenfluramine hydrochloride (Redux) with other serotoninergic agents warrants additional comment. The authors neglected to point out that the serotonin syndrome appears to be rare, even among patients taking serotoninergic drug combinations.<sup>1,2</sup>Without their making this point, readers may be misled by their suggestion that large numbers of people are at risk for this syndrome. Serotonin syndrome has been reported more often with certain drug combinations such as MAOIs used with serotoninergic agents and is reported less frequently with other drug combinations.<sup>1</sup>By not making this distinction, it appears that all the agents cited by the authors represent a similar risk when used with dexfenfluramine. The lack of reported cases of serotonin syndrome in patients receiving dexfenfluramine alone or in combination with other agents is reassuring, especially in view of its widespread clinical
Future of British psychiatrists.
Journal: BMJ (1971)

libido, and hypertension.The authors compare these symptoms with those encountered in hepatitis2 and in the first three months of pregnancy.3They suggest that the cause may lie in a disturbance of trace metals4 and report that treatment with orally administered copper, zinc, or nickel has resulted in the return of taste to normal.4 5 The patients ranged in age from 34 to 68 years, and half of them had a preceding infection of the upper respiratory tract.The authors used different dilutions of the salty, sweet, bitter, and sour solutions to test taste.As an objective measurement of smell they used pyridine in water and nitrobenzene and thiophene in mineral oil in various concentrations.Three case histories given show that the ob- noxious taste and smell of food caused the patients to lose 10-30 lb (4-5-13.6 kg) in weight.The authors describe pathological changes in the pore region of a taste bud, where they found fewer neurosecretory granules than normal, larger vacuoles, and more highly vesiculated cells but loss of cyto- plasmic projections.These histological changes lend support to the proposition that a disorder with a distinct pathology is the explanation of these unpleasant symptoms.Henkin and colleagues report that they know of at least 3,000 sufferers from this complaint, and they are engaged in a double-blind trial of zinc given by mouth to try and confirm their initial favourable results.
Gonorrhea and Impotency: Modern Treatment.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Twelfth International Leukocyte Culture Conference
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Twelfth International Leukocyte Culture Conference Get access JNCI: Journal of the National Cancer Institute, Volume 60, Issue 4, April 1978, Page 935, https://doi.org/10.1093/jnci/60.4.935-a Published: 01 April 1978
Eighth Summer Program in Methods of Immunologic Research and Diagnosis
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Eighth Summer Program in Methods of Immunologic Research and Diagnosis Get access JNCI: Journal of the National Cancer Institute, Volume 74, Issue 1, January 1985, Page 266, https://doi.org/10.1093/jnci/74.1.266 Published: 01 January 1985
The ARDS Lung
Authors: Roger C. Bone
Journal: JAMA (1993)

Although it has been 26 years since Ashbaugh et al<sup>1</sup>first described the adult (or "acute," as we are now calling it) respiratory distress syndrome (ARDS), little progress has been made in improving survival. However, a group headed by Luciano Gattinoni, MD, at the University of Milan in Italy, has contributed greatly to our knowledge of the correlation between lung structure and function in ARDS through the use of computed tomography (CT). In this issue ofThe Journal, they add some important observations to the information they have already presented in previous reports.<sup>2</sup>This new information may have important clinical implications in the treatment of patients with ARDS. The significance of the study lies in its implications for therapy; it should be stressed that CT cannot be used routinely as a monitoring technique. See also p 2122. One reason that so little progress has been made in treating
Closing the chapter on Maharishi Ayur-Veda
Authors: V. D. Tompkins
Journal: JAMA (1992)

<h3>To the Editor.</h3> —With regard to the report on Maharishi Ayur-Veda in your October 2, 1991, issue,<sup>1</sup>it seems to me that the indignation expressed was disingenuous. The original article on Maharishi Ayur-Veda published in the May 22/29, 1991, issue<sup>2</sup>clearly referred to Maharishi Mahesh Yogi and the TM program. One of its authors was described as president of the organization that trains physicians in Maharishi Ayur-Veda. And, in the October 11, 1990, letter submitted to<i>JAMA's</i>editors with the original article, the authors disclosed that they were consultants to a Maharishi Ayur-Veda organization.<sup>3</sup>In light of this,<i>JAMA's</i>editors must have known before May about such a connection. Therefore,<i>JAMA's</i>October attack, predicated as it was on alleged deception, seems to me to have been unjustified. I think your readers should know that our organization has always been straightforward in presenting Maharishi Ayur-Veda to the public.
DOES PREVENTION PREVENT?
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Excessive new origin firing underlies selective glioma stem cell cytotoxicity induced by replication stress response inhibition
Authors: Emily Clough, Karen Strathdee, Ross Carruthers
Journal: Neuro-Oncology (2021)

Abstract Aims Glioblastoma (GBM) is a treatment refractory cancer of extreme unmet need which exhibits treatment resistance due to a subpopulation of GBM cancer stem cells which have constitutive DNA damage response activation driven by elevated replication stress (RS). RS response inhibition is potently cytotoxic to GSC, however mechanistic understanding will be key to biomarker discovery and successful clinical translation. We investigated response to combined ATR and PARP inhibition (CAiPi) to gain mechanistic insight and inform biomarker development. Method A panel of patient-derived GBM cell lines were cultured as stem enriched (GSCs) or stem depleted (bulk), to characterise response to combined ATR inhibition (VE821 5μM) and PARP inhibition (Olaparib 1μM), by CellTiter-Glo viability assay. Mechanistic investigations included immunofluorescence of 53BP1 nuclear bodies and DNA fibre analysis. Studies into the importance of PARP trapping included another PARPi Veliparib (1μM), and investigations into inhibition of origin firing used the CDK inhibitor Roscovitine. Results Responses to CAiPi in a panel of primary paired GBM GSCs vs differentiated progeny were heterogenous. CAiPi is selectively GSC cytotoxic in a subpopulation of tumours. DNA fibre analysis identified increased new origin firing with PARPi, which was correlated with increased PARP trapping. Inhibition of origin firing by exposure to roscovitine rescued the CAiPi cytotoxic phenotype, suggesting origin firing has an important role in selective GSC cytotoxicity. A population of treatment-sensitive GSCs with increased numbers of 53BP1 nuclear bodies in G1 phase with CAiPi were identified, indicative of under-replication of DNA in S phase. Conclusion Selective GSC cytotoxicity is induced by CAiPi via dysregulation of replication, by both DNA under-replication resulting in DNA lesions, and the novel finding of increased new origin firing in GSC due to PARPi.
Variability in the Measurement of Hospital-wide Mortality Rates
Authors: Michio Ozeki
Journal: New England Journal of Medicine (2011)

corrections ly returned to school and has received daily oral propranolol for 10 months (Fig. 1, inset c).The blood VEGF level decreased remarkably after the administration of propranolol.However, it is premature to conclude that the reduction in VEGF defines its role in the mechanism of action.The prognosis for patients with diffuse lymphangiomatosis is poor if the condition is resistant to standard therapies.
Types of Exudates in Diabetic Retinopathy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corticosteroid-induced glaucoma and cataracts in contact lens wearers
Authors: R. M. Burde
Journal: JAMA (1970)

The indiscriminate topical application of corticosteroids to the eyes of two young patients induced cataracts and glaucoma with permanent visual defects. Individuals with a high degree of myopia and family history of glaucoma are more susceptible than others to this condition.
化脓性汗腺炎研究的核心结果的全球共识:历史性共识会议I和II的更新
Authors: L. Thorlacius, A. Garg, J.R. Ingram, B. Villumsen, P. Theut Rii, A.B. Gottlieb, J.F. Merola, R. Dellavalle, C. Ardon, R. Baba, F.G. Bechara, A.D. Cohen, N. Daham, M. Davis, L. Emtestam, P. Fernández-Peñas, M. Filippelli, A. Gibbons, T. Grant, S. Guilbault, S. Gulliver, C Harris, C. Harvent, K. Houston, J.S. Kirby, L. Matusiak, A. Mehdizadeh, T. Mojica, M. Okun, D. Orgill, L. Pallack, A. Parks-Miller, E.P. Prens, S. Randell, C. Rogers, C.F. Rosen, S.E. Choon, H.H. van der Zee, R. Christensen, G.B.E. Jemec
Journal: British Journal of Dermatology (2018)

化脓性汗腺炎(HS)是一种罕见的皮肤症状,会在皮肤褶皱处(腋下、胸下、腹股沟和臀部)引起疼痛的红色肿块。HS可能会被误诊为细菌性脓肿或烫伤,但它并不是由细菌引起的。HS发生在约0.1~1%的美国和欧洲人中。作者包括来自4大洲、13个国家/地区的HS患者、皮肤科医生、外科医生、制药行业成员和医疗监管机构人员。本项研究旨在找出应衡量哪些HS临床试验,例如症状(如疼痛、瘙痒)、生理变化(如皮肤发红或肿胀)或对人们生活的影响(如生活质量)。为此,本研究包含了两个组:HS患者和保健服务提供者(医生、制药行业代表和监管代表),并采用面对面会议陈述、讨论以及调查的方式进行,以便收集应包含哪些衡量因素的相关意见。会议、讨论和调查的结果表明,至少有70%的HS患者和保健服务提供者建议临床试验包含以下衡量因素:(1)因HS导致的生理变化(如发红);(2) HS发病期间的变化(如病情发作);(3)特别是因HS而导致的生活质量变化;(4)满意度(如对治疗的满意度);(5)疼痛;(6)其他症状(如瘙痒);和全局评级(即,考虑所有因素的病情严重程度整体评级)。这项工作相当重要,因为其中包含了许多不同类型的对HS治疗做出贡献的人员,包括HS患者、开发或监管治疗的人员,以及治疗HS患者的人员。更多的工作还在进行中,这些工作将重点提供有关HS治疗试验中的衡量因素和如何衡量的最终建议。
Dissecting Aneurysms
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detection of phenylketonuria in autistic and psychotic children
Authors: T. L. Lowe
Journal: JAMA (1980)

Sixty-five children with pervasive developmental disturbance (autism and atypical childhood psychosis) were screened by standard urinary amino acid detection testing methods. Three of the children showed abnormalities in these screening tests, leading to the diagnosis of phenylketonuria. This was verified by repeated urinary testing and blood phenylalanine determinations. The children with phenylketonuria were treated with low-phenylalanine diets and have shown improvement in functioning and developmental level since treatment. Urinary genetic screening should be a standard test for all children being evaluated for serious developmental disturbances of childhood. (<i>JAMA</i>243:126-128, 1980)
Immediate-term chemotherapy-related cognitive impairment (CRCI) following administration of intravenous (IV) chemotherapy.
Authors: Omar Farooq Khan, Ellen R. Cusano, Soundouss Raissouni, Mica Pabia, Johanna Haeseker, Nicholas Adam Bosma, Jenny J. Ko, Aalok Kumar, Steven Yip, Michael M. Vickers, Patricia A. Tang
Journal: Journal of Clinical Oncology (2017)

10084 Background: The acute impact of chemotherapy on cognition is unknown. This study utilized performance on the psychomotor vigilance task (PVT) and trail-making test B (TMT) to assess CRCI immediately following chemotherapy administration. Methods: Patients aged 18-80 years receiving first-line IV chemotherapy for any stage of breast or colorectal cancer were eligible. Patients with brain metastases, neurologic disorders or allergic reactions to chemotherapy were excluded. Patient symptoms, peripheral neuropathy and Stanford Sleepiness Scale were assessed. A five-minute PVT and TMT were completed on a tablet computer pre-chemotherapy and immediately post-chemotherapy. Paired Wilcoxon Rank Sum tests were used to assess change in median PVT reaction time, TMT completion time, TMT errors and PVT lapses. A priori, an increase in median PVT reaction times by over 20 ms (approximating reaction time changes with blood alcohol concentrations of 0.04 to 0.05 g%) was considered a clinically relevant change. Results: 144 patients (74 breast, 70 colorectal, median age 55.5 years) were tested. Post-chemotherapy, median PVT reaction time slowed by an average of 12.4 ms ( p = 0.01). Post-chemotherapy median PVT times slowed by over 20 ms in 59 patients (40.9%). TMT completion post-chemotherapy was faster by an average of 6.1 seconds ( p &lt; 0.001). No differences were seen in TMT errors ( p = 0.417) or PVT lapses ( p = 0.845). Change in median PVT reaction time was not associated with age, gender, number of prior chemotherapy cycles, peripheral neuropathy grade, self-reported symptoms (anxiety, fatigue or depression). Change in median PVT reaction time was also not significantly associated with use of any specific chemotherapeutic drug or class, including paclitaxel (which includes ethanol as an excipient). Conclusions: Median PVT reaction time was significantly slower immediately after chemotherapy compared to a pre-chemotherapy baseline, and impairment correlating to effects of alcohol was seen in 41% of patients. This effect appears independent of age, self-reported symptoms or prior chemotherapy cycles. Further studies assessing functional impact of immediate-term CRCI are warranted.