tbuckley/cabot-search huggingface dataset:
Therapy of relapsed/refractory metastatic triple-negative breast cancer (mTNBC) with an anti-Trop-2-SN-38 antibody-drug conjugate (ADC), sacituzumab govitecan (IMMU-132): Phase II results.
Authors: Aditya Bardia, Jennifer Robinson Diamond, Wells A. Messersmith, Ingrid A. Mayer, Steven J. Isakoff, Vandana Gupta Abramson, Jordan Berlin, Alexander Starodub, Joyce O'Shaughnessy, Kevin Kalinsky, Rebecca L. Moroose, Nikita C. Shah, Dejan Juric, Geoffrey Shapiro, Michael J. Guarino, Allyson J. Ocean, Francois Wilhelm, Robert M. Sharkey, David M. Goldenberg, Linda T. Vahdat
Journal: Journal of Clinical Oncology (2016)

LBA509 The full, final text of this abstract will be available at abstracts.asco.org at 2:00 PM (EDT) on Friday, June 3, 2016, and in the Annual Meeting Proceedings online supplement to the June 20, 2016, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.
Evoked potentials give early warning of sensory and behavioral deficits in high-risk neonates
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Protein Abnormalities in Ulcerative Colitis Patients and Their Families
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cellular Changes with Age
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 533: OTULIN promotes resistance and metastasis upon chemotherapy in TNBC by activating Wnt/β-Catenin signaling
Authors: Wei Wang, Jixiao Niu, Bo Zhang, Zhaohui Wu
Journal: Cancer Research (2018)

Abstract Triple-negative breast cancer (TNBC) or Basal-like breast cancer is characterized by worse prognosis than other breast cancer subtypes due to the rapid-arising therapeutic resistance accompanied by aggressive metastasis. The therapy-resistant tumor cells, including cancer stem-like cells (CSCs) with intrinsic resistance or tumor cells acquired resistance during treatments, could repopulate the primary tumors and serve as seeds for recurrent metastatic lesions. However, the molecular events orchestrating the innate and acquired therapeutic resistance are not completely understood. We found that the linear ubiquitin-specific deubiquitinase OTULIN is overexpressed in breast tumors, especially in the basal-like subtype, compared with normal breast tissues. Moreover, OTULIN overexpression significantly increased TNBC cells resistance to chemotherapy and is associated with shorter DFS in breast cancer patients. Mechanistically, we found genotoxic treatments activate OTLULIN, which promotes epithelial-to-mesenchymal transition (EMT) in TNBC cells through increased activity of Wnt/β-Catenin signaling. OTULIN overexpression significantly enhanced TNBC cells resistance to chemodrugs while inhibiting Wnt/β-Catenin signaling or OTULIN sensitized TNBC xenografts to Doxorubicin treatment in vivo. Our findings suggest that OTULIN-mediated Wnt/β-Catenin activation may increase TNBC therapeutic resistance and aggressiveness by promoting EMT. Targeting OTULIN and the chemotherapy-induced Wnt/β-Catenin activation may serves as promising strategy to mitigate drug resistance and reduce metastasis in TNBC patients receiving chemotherapy. Citation Format: Wei Wang, Jixiao Niu, Bo Zhang, Zhaohui Wu. OTULIN promotes resistance and metastasis upon chemotherapy in TNBC by activating Wnt/β-Catenin signaling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 533.
List no 72. New names
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patent Foramen Ovale in Young Adults with Unexplained Stroke
Authors: Giancarlo Agnelli
Journal: New England Journal of Medicine (2006)

ters on coronary-artery revascularization focus on percutaneous coronary intervention or coronaryartery bypass grafting; they barely mention the medical reperfusion treatment of myocardial infarction.The chapters about peripheral arterial disease and stroke are well written.Surprisingly, the book does not include a chapter on the treatment of venous thromboembolism, but it does contain one chapter on the management of venous thromboembolism during pregnancy and one chapter on thromboembolic disease in children.Both chapters are written by authors with remarkable experience in these fields.In conclusion, Thrombosis in Clinical Practice is well written and includes much up-to-date information.Despite some inconsistencies and overlapping content among chapters, it focuses on issues that are not addressed in other books on the same topic.
Mortality among oral contraceptive users.
Journal: BMJ (1990)

Ovarian failure after total body irradiation SIR,-Dr M P Cust and colleagues only touch on the possible long term effects of total body irradia- tion,' but these need to be addressed as increasing numbers of patients are successfully treated.We measured bone mineral content and density in the lumbar spine in 14 women who had premature ovarian failure after treatment for haematological malignancies.On average, 51 months had elapsed since treatment.We used a dual energy x ray absorption technique with a precision of 1%.2The patients' mean vertebral bone density was 0 97 (SD 0 15) g/cm2; that of a control group' of 68 women in the same age range (19 to 45, mean age of both groups 33 years) was 1 07 (0 09) g/cm2 (p=004, Student's t test).The patient with the lowest bone mineral density (0 71 g/cm') had already suffered an atraumatic fracture of a meta- tarsal bone.The loss of almost 10% of bone mineral in this short time implies that these patients are at risk of developing osteoporosis in the future.We support the recommendation of Dr Cust and colleagues that they should be referred to a gynaecologist or endocrinologist to consider hormone replacement therapy.
Abstract 1096: Response of pancreatic ductal adenocarcinoma to gemcitabine using human organotypic slice cultures
Authors: Jae Hyuck Chang, Chae Yoon Lim, Weon Sun Lee, Guk Jin Lee
Journal: Cancer Research (2019)

Abstract Background/Objective: The oragnotypic tumor slice culture model resembles the in vivo situation of tumor. It may serve as a proper ex vivo platform for response to anti-tumor therapies. We aimed to evaluate the response of pancreatic ductal adenocarcinoma (PDA) cells and helper, cytotoxic, and regulatory T cells to gemcitabine using human PDA slice culture model. Methods: PDA tissues were obtained from patients who were operated on for pancreatic resection. The tumors were sliced by a vibratome, and the tumor slices were then cultured until 5 days with 0.1 μM, 1 μM, and 10 μM gemcitabine for 1 or 2 days. Tumor responses were evaluated by number of tumor cells and proportion of Ki-67 or caspase-3 positively expressed cells in the tumor. CD4+, CD8+, and FOXP3+ cells were analyzed by immunohistochemistry staining. Results: Gemcitabine treatment to PDA slices exerted proportional cytotoxic effects in terms of tumor cell number, and Ki-67 and cleaved caspase-3 expression. Mean Ki-67 positive cells in PDA cells tended to decrease according to increase of gemcitabine concentration (case 1, 48 hr treatment; 65.7% in control vs. 27.9% in 0.1 μM, p=0.025). Mean caspase-3 positive cells in PDA cells tended to increase according to increase of gemcitabine concentration (case 1, 48 hr treatment; 8.6% in control vs. 18.6% in 0.1 μM, p=0.042). Mean PDA cells per x200 tended to decrease according to increase of gemcitabine concentration (case 2, 48 hr treatment; 78.3 in 1.0 μM vs. 27.3 in 10 μM, p=0.042). Mean CD4+, CD8+, and FOXP3+ cells/total cells tended to decrease according to increase of gemcitabine concentration; in case 3 (24hr treatment), mean CD4+ cells/total cells decreased as 2.6%, 1.6%, 1.5%, and 0.5%, mean CD8+ cells/total cells decreased as 2.6%, 1.5%, 1.4%, and 1.1%, and mean FOXP3+ cells/total cells were 0.2%, 0.3%, 0.2%, and 0.1% in control, 0.1 μM, 1 μM, and 10 μM gemcitabine, respectively. However, mean CD8+/FOXP3+ cell ratio did not significantly decrease, and even increase from 4.4 in 0.1 μM to 8.6 in 1 μM (p=0.039). Conclusions: Tumoricidal effect of gemcitabine could be demonstrated using organotypic slice culture model. T cells in the tumor decreased according to increase of gemcitabine concentration; however CD8+/FOXP3+ cell ratio relatively maintained. Citation Format: Jae Hyuck Chang, Chae Yoon Lim, Weon Sun Lee, Guk Jin Lee. Response of pancreatic ductal adenocarcinoma to gemcitabine using human organotypic slice cultures [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1096.
Diagnostic performance of a new algorithm combining simple, non-invasive and inexpensive tests for predicting the presence of liver severe fibrosis and cirrhosis in patients with chronic hepatitis B
Authors: Jean Nana, Skaare Kristina, Tarik Asselah, Adler Michael, Marie-Noëlle Hilleret, Vincent Leroy, Marlu Alice, Jean Luc Bosson, Jean-Pierre Zarski
Journal: Journal of Hepatology (2020)
AIDS, associated disorders pose complex therapeutic challenges
Authors: H. Cole
Journal: JAMA (1984)

Very T ery little optimism emerged from a panel discussion entitled "AIDS [acquired immunodeficiency syndrome] Therapeutic Trials and Alternative Treatments" at the recent annual meeting of the American Association of Physicians for Human Rights, held in Chicago. Panel members Paul Volberding, MD; Stephen Follansbee, MD; and Donald Abrams, MD, agreed that the usual therapeutic approaches to malignancy, infection, and associated manifestations of the syndrome (such as immune thrombocytopenic purpura [ITP]) may not be optimum in the setting of AIDS. "AIDS is not a disease to approach in the traditional way," said Volberding. In discussing his approach to patients with Kaposi's sarcoma, Volberding (who is codirector of the Kaposi's sarcoma clinic at the University of California, San Francisco) emphasized that Kaposi's in the setting of AIDS does not appear to be the same disease as that seen in the original cases occurring in elderly men of Ashkenazi Jewish and Mediterranean ancestry
A Shocking Turn of Events
Authors: Ersilia M. DeFilippis, Piotr Sobieszczyk, Neal K. Lakdawala, Amy L. Miller, Joseph Loscalzo
Journal: New England Journal of Medicine (2018)

A 38-year old woman presented to her physician's office with shortness of breath, nonproductive cough, palpitations, and chest tightness. She had no lightheadedness or syncope.
West of London Hospital, Hammersmith
Journal: BMJ (1862)

stone, and after neither sitting was the urine stained by a single drop of blood.At the time of operation Mr. Maunder explained the two methods of using the lithotnte, preferring that of Civiale as being likely to do less injury to the bladder than that of Brodie, in which latter, of necessitv, the blades of the instrument come in contact with that viscus.One hundred and fifty grains of benzoic acid, administered over a period of seventy-two hours, had removed the am- moniacal odour, and rendered the urine acid.
A Case of a Laboratory Animal Feed with High Estrogenic Activity and Its Impact on in Vivo Responses to Exogenously Administered Estrogens
Authors: Holly Boettger-Tong, Lata Murthy, Constance Chiappetta, John L. Kirkland, Bradford Goodwin, Herman Adlercreutz, George M. Stancel, Sari Makela
Journal: Environmental Health Perspectives (1998)

We recently noted that immature rats failed to exhibit a normal uterine response to exogenously administered estradiol as assessed by both biochemical (induction of gene expression) and morphological (altered uterine and vaginal histology and size) end points. An initial analysis suggested that this was due to a high degree of estrogenization from a dietary source which was producing a near maximal uterotrophic response prior to hormone treatment. Subsequent chemical analysis indicated that the feed in question contained high amounts of two well-known phytoestrogens, genistein (210 mg/kg) and daidzen (14 mg/kg), and the lot of feed in question produced a large uterotrophic effect when fed to immature ovariectomized rats. These findings illustrate that, despite increased awareness of phytoestrogens, some batches of animal feed contain very high amounts of estrogenic components which have marked effects on in vivo end points of hormone action. These observations have important implications for both basic research and screening methods that utilize in vivo approaches.
Evolution Of Class-I MHC Genes And Proteins: From Natural Selection To Thymic Selection
Authors: D. Lawlor
Journal: Annual Review of Immunology (1990)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Reports of the Judicial Council of the American Medical Association, December 1984
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Laboratory profile screening in family practice. A five-year study
Authors: T. E. Rardin
Journal: JAMA (1970)

Reports from private medical offices of data obtained when routine laboratory screening studies were made a part of each health evaluation have not been common. This report analyzes 2,919 laboratory profiles secured on 1,204 patients examined in a five-year period. Repeated profile screening has certain limitations but contributes much to a physician's understanding of each patient's health status. Laboratory screening is economical and should be considered along with other diagnostic and screening modalities. The pathologist skilled in laboratory medicine should be included as a member of the family physicianconsultant team in continuing and comprehensive family medical care. Routine laboratory screening, as part of each periodic health evaluation, offers the family physician a great challenge. A program of collaborative research in this aspect of laboratory medicine would appear justified.
Efficacy of Dasatinib in Patients (pts) with Previously Untreated Chronic Myelogenous Leukemia (CML) in Early Chronic Phase (CML-CP).
Authors: Jorge Cortes, Susan O’Brien, Dan Jones, Charles Koller, Gautam Borthakur, Claude Nicaise, Laverne Henderson, Alessandra Ferrajoli, Hagop Kantarjian
Journal: Blood (2007)
THE PROTOPLASMIC REACTION OF LIVING CELLS
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Question and Answers
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal