Continuous Hemofiltration
Authors: DONALD J. KENNEDY
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Continuous HemofiltrationDONALD J. KENNEDY, M.D., RICHARD N. GREENBERG, M.D., LESLIE W. MILLER, M.D.DONALD J. KENNEDY, M.D.Search for more papers by this author, RICHARD N. GREENBERG, M.D.Search for more papers by this author, LESLIE W. MILLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-145_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Kaplan and associates described their experience with continuous hemofiltration in the March issue (1, 2). Although this technique appears to be extremely useful for the removal of water, salt, and other unwanted low-molecular-weight substances, we are concerned about the lack of information on drug clearance by this technique. Our limited clinical experience with slow continuous ultrafiltration has shown that selected aminoglycoside antimicrobials with low-protein-binding characteristics and a low toxic to therapeutic concentration ratio are significantly cleared by this procedure. Although ultrafiltration without fluid replacement theoretically should not alter the net metabolism of drug in these patients, the...References1. KAPLANLONGNECKERFOLKERT ARV. Continuous arteriovenous hemofiltration: a report of six months' experience. Ann Intern Med. 1984;100:358-67. LinkGoogle Scholar2. TWARDOWSKINOLPH ZK. Blood purification in acute renal failure [Editorial]. Ann Intern Med. 1984;100:447-9. LinkGoogle Scholar3. BENNETTMUTHERPARKER WRR. Drug therapy in renal failure: dosing guidelines for adults: Part I. Antimicrobial agents, analgesics. Ann Intern Med. 1980;93(1 pt):62-89. LinkGoogle Scholar4. BENNETTMUTHERPARKER WRR. Drug therapy in renal failure: dosing guidelines for adults: Part II. 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Boston: Martinus Nijhoff Publishers; 1983:265-74. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis University School of Medicine St. Louis, MO 63104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByContinuous Renal Replacement Therapy (CRRT) in the Intensive Care UnitContinuous Arteriovenous HemofiltrationGentamicin and phenytoin sieving through hollow–fiber polysulfone hemofiltersContinuous Arteriovenous Hemofiltration in Acute Renal Failure 1 July 1984Volume 101, Issue 1Page: 145-147KeywordsAntimicrobialsAttentionDrug informationDrug metabolismDrugsHemofiltrationSaltsUltrafiltration Issue Published: 1 July 1984 PDF DownloadLoading ...