tbuckley/cabot-search huggingface dataset:
Nortriptyline in depressed patients with left ventricular impairment
Authors: S. P. Roose
Journal: JAMA (1986)

Previous studies of the effect of tricyclic antidepressants on left ventricular function in depressed patients with moderate to severe ventricular impairment have focused primarily on imipramine hydrochloride. In a prior study, we found that although imipramine had no effect on ejection fraction as measured by first-pass radionuclide angiography, the treatment could not be tolerated by 50% of the patients because of intolerable drug-induced orthostatic hypotension. Nortriptyline hydrochloride is an effective antidepressant that, in depressed patients without heart disease, causes significantly less orthostatic hypotension than imipramine. To see if this advantage could be safely extended to patients with congestive failure, we measured the effect of nortriptyline on ejection fraction and blood pressure in 21 depressed patients with left ventricular impairment. Ejection fraction was unchanged by nortriptyline treatment, and orthostatic hypotension developed in only one (5%) of 21 patients. Nortriptyline emerges as a relatively safe treatment for depression in patients with left ventricular impairment. (<i>JAMA</i>1986;256:3253-3257)
Erratum: Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leykemia
Authors: M Tartaglia, C M Niemeyer, A Fragale, X Song, J Buechner, A Jung, K Hählen, H Hasle, J D Licht, B D Gelb
Journal: Nature Genetics (2003)
LOCAL ANESTHESIA FOR SIMPLE MASTOID OPERATIONS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2159: Label-free impedance analysis as a versatile tool for dynamic screening of cancer molecular therapeutics
Authors: Fabio Cerignoli, Biao Xi, Brandon Lamarche, Leyna Zhao, Yama Abassi
Journal: Cancer Research (2019)

Abstract In vitro monitoring cancer cells response to treatment often involves laborious sample processing and collects single data points that are against the dynamic nature of cancer cells. Here we present the adaptation of an impedance-based methodology to dynamically monitor cancer cell behavior and therapeutic response. The technology detects cell death, proliferation or migration by measuring changes in conductance of microelectrodes embedded in 96 and 384-wells cell culture plates. It avoids sample labeling and processing and allows continuous monitoring of cell response. Our data shows validation with cancer cell lines and primary cells monitored for cell invasion/migration through transwells or after a scratch has been performed with a dedicated device, anticancer drug response and receptor signaling activation, with similar results over end point assays. Easy experiment set up and minimal sample processing make the technology ideal for applications in large screening campaigns, while label-free technology allows less artifacts and further analysis on the same samples through orthogonal assays. Citation Format: Fabio Cerignoli, Biao Xi, Brandon Lamarche, Leyna Zhao, Yama Abassi. Label-free impedance analysis as a versatile tool for dynamic screening of cancer molecular therapeutics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2159.
A Meta-analysis of Estrogen Replacement and Breast Cancer
Authors: Malcolm Law
Journal: JAMA (1991)

<h3>To the Editor.</h3> — Steinberg et al<sup>1</sup>estimate that there is a 30% increase in the risk of breast cancer after 15 years of estrogen use. This conclusion is critically dependent on the model selected for the relationship between risk and duration of use. Their assumed model is as follows: risk α k<sub>1</sub><sup>duration</sup>(or log [risk] = duration × log [k<sub>1</sub>]). An equally plausible model (shown to fit the data on smoking and lung cancer) is the following: risk α duration<sup>k</sup>(or log [risk] = k<sub>2</sub>× log [duration]). In both equations k<sub>1</sub>and k<sub>2</sub>are constants. From Table 2 in the paper by Steinberg et al, the value of k<sub>1</sub>is 1.018 (adding 1.0 to the proportional increase in risk of 0.018). This predicts an RR after 5 years' use of 1.09(1.018<sup>5</sup>). The second model predicts lower estimates for the excess
A FALSE STEP.
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endothelium-Dependent and -Independent Perfusion Reserve and the Effect of <scp>l</scp> -arginine on Myocardial Perfusion in Patients With Syndrome X
Authors: Morten Bøttcher, Hans Erik Bøtker, Helle Sonne, Torsten Toftegaard Nielsen, Johannes Czernin
Journal: Circulation (1999)

Background —Impaired vasodilatation capacity in patients with angina pectoris and a normal coronary arteriogram (syndrome X [SX]) has been reported. Most studies report on the response in epicardial vessels. This does not necessarily reflect compromised myocardial microcirculation. Lack of the NO precursor l -arginine has been suggested as a possible cause. Methods and Results —Myocardial blood flow (MBF) was measured, using PET, at rest (MBF-rest) and during intravenous dipyridamole (MBF-DIP) in 25 women (mean age 53±7 years) with SX. Thirty healthy volunteers served as controls. One group (A) consisted of 15 age-matched female volunteers (54±10 years). The other control group consisted of 15 young healthy women (B; 24±5 years). In 12 SX patients, MBF-rest and MBF during cold pressor testing were also measured after infusion of L-arginine (6.7 g/min for 45 minutes). The increase in MBF after cold pressor testing was similar in the SX group compared with controls. l -arginine did not affect MBF-rest (0.83±0.14 versus 0.89±0.13 mL · g −1 · min −1 ) or MBF after cold pressor test (0.95±0.10 versus 1.03±0.17 mL · g −1 min −1 ). In contrast, the hyperemic response to DIP was blunted compared with the group A controls (1.68±0.49 versus 2.34±0.45 mL · g −1 · min −1 , P &lt;0.05); this resulted in a significant reduction of the coronary flow reserve in SX patients relative to controls (2.03±0.53 versus 2.96±0.63 mL · g −1 · min −1 , P &lt;0.01). Conclusions —In patients with SX, the microcirculatory response to cold, reflecting the endothelium function, is normal and unaltered by intravenous l -arginine. This suggests preserved microcirculatory endothelial function. However, a markedly attenuated hyperemic flow and flow reserve after DIP suggest a dysfunction of the adenosine-mediated endothelium-independent vasodilatation at the microcirculatory level in these patients.
DERMATOLOGICAL SECTION
Journal: British Journal of Dermatology (1910)

British Journal of DermatologyVolume 22, Issue 1 p. 13-26 DERMATOLOGICAL SECTION First published: January 1910 https://doi.org/10.1111/j.1365-2133.1910.tb16585.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume22, Issue1January 1910Pages 13-26 RelatedInformation
Antibiotics and hepatic artery ligation in germfree and conventional dogs
Authors: J. N. Crook
Journal: JAMA (1970)

Anaerobic bacteria harbored in the liver of the dog have been shown to be the cause of death in this animal after hepatic artery ligation. The protective effect of antibiotics is well recognized. Forty-nine conventional and two germfree dogs were studied after hepatic artery ligation to evaluate this problem further. No conventional dogs survived without antibiotics. Antibiotics in large doses protected 81% of conventional dogs; 47% of dogs treated four days prior to surgery survived. The two germfree animals survived without antibiotics. This reaffirms the role of bacterial sepsis of the liver as the cause of death in the dog after hepatic artery ligation and emphasizes the small doses of antibiotics necessary for protection of conventional dogs and the survival of germfree dogs without antibiotics.
The Practitioner's Encyclopedia of Medicine and Surgery in All Their Branches.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cases of Nerve-Disorder, Recorded with Reference to the Probable Operation of Malaria as a Cause
Authors: C. H. Jones
Journal: BMJ (1857)

lint, wvetted in water, were gently applied around the injured menmbers, beginning from their ungual ends until a complete splint was thus formed.The stripes of lint were applied layer upon layer as high up as the wrist joint.The whole hand was then enveloped in wet lint, and supported on a pillow so that a constant stream of water might flow over it from the irrigator.Considerable henmorrhage occurred during the first twelve hours.For a few days afterwards active inflammation existed, which was controlled, however, and in eight days the edges of the wound showed healthy granulations.Irrigation was still continued for a few days longer, after which wet lint alone was applied.About the middle of June the wound was quite healed; and when he left the hospital he had a useful hand.He could flex and extend the index finger, and bring the thumb in contact with it firmly.The thumb was partially dis- located forwards, and did not allow of much movement.CASE iII.Lacerated JWound of the Joints between the First and Second Phalanges of the Index and Middle Fingers: Both Sated.A boy, aged 16 years, was admitted in Guy's under my care in February, 1857.A severe injury had been inflicted on his right hand by a circular saw, just before ad- mission.The little and ring fingers were merely hanging by stripes of integument; and my dresser, Mr. Broad, removed these through the first phalanx.The joints between the first and second phalanges of the index finger and middle were cut
Contact dermatitis to neomycin sulfate
Authors: J. J. Leyden
Journal: JAMA (1979)

The prevalence of contact allergic dermatitis and nonallergic irritant reactions to neomycin sulfate was determined in a large group of young adults who had a noteworthy exposure to topical antibiotics. Only two subjects (0.09%) had contact allergy proved by closed patch testing, while 20 (0.9%) had nonallergic irritant reactions to 20% neomycin sulfate and 17 (0.78%) had nonallergic reactions to one of the hydrophilic ointment bases. In a separate population of 653 children referred for diagnostic patch testing, only one subject had contact allergy to neomycin. All three subjects who had reactions had a history of repeated use of neomycin on chronically damaged skin. These results support the conclusion that intermittent use of neomycin on minor cuts and wounds is not associated with an excessive rate of sensitization. (<i>JAMA</i>242:1276-1278, 1979)
American Journal of Public Health, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatology Highlights
Authors: Nicholas Russo, Robert S. Brown, Shirley Cohen‐Mekelburg, Robert E. Schwartz, Vikas Gupta, Joseph F. Pisa, Russell Rosenblatt, Aleksey Novikov
Journal: Hepatology (2018)

Russo, Nicholas1; Brown, Robert S. Jr1; Cohen‐Mekelburg, Shirley1,†; Schwartz, Robert E.1; Gupta, Vikas1,†; Pisa, Joseph F.1; Rosenblatt, Russell1,†; Novikov, Aleksey1,† Author Information
Survival during fasting may depend on fat as well as protein stores
Authors: L. A. Leiter
Journal: JAMA (1982)

The determinants of length of survival during total fasting are unknown. Media reports of hunger strikers in Northern Ireland have provided some basis for evaluating this question. Such "data" combined with standard concepts of body composition, fuel homeostasis, and responses to therapeutic fasts suggest that death occurred when fat stores were approaching exhaustion. Thus, fat stores may play a central role. (<i>JAMA</i>1982;248:2306-2307)
US Government inquiry bodies dismiss scientific misconduct charges against AIDS researchers
Authors: C. Marwick
Journal: JAMA (1993)

THE TWO longest-standing cases of scientific misconduct have been shelved. One case, that of Mikulas Popovic, MD, was dismissed by a Department of Health and Human Services appeals board after holding a hearing on the charges; in the second case, that of Robert Gallo, MD, the misconduct charges have been dropped by the Office of Research Integrity (ORI). Both scientists worked on AIDS and other research at the Laboratory of Tumor Cell Biology of the National Cancer Institute, Bethesda, Md. Gallo is the head of the laboratory. Even as the ORI announced that it was dropping its charges of misconduct by Gallo on the grounds that it would have been, it says, "extraordinarily difficult" to win the case—although Congress may decide to reinvestigate the entire matter—lawyers for the Pasteur Institute in France announced that they intend to continue their efforts to obtain a higher percentage of the royalties from the
Trust
Authors: Samuel C Durso
Journal: Annals of Internal Medicine (2002)

On Being a Patient17 December 2002TrustSamuel C. Durso, MDSamuel C. Durso, MDThe Johns Hopkins University School of Medicine Baltimore, MD 21236Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-12-200212170-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “How'd you miss that frog, Doc?” There was a tinge of irritation in Ezra's voice.No use making an excuse. I steadied my balance, planting both feet astride the flat-bottomed boat and squeezed my eyes shut to stop the stinging. Sweat ran over my brow, down my cheeks and into the corners of my mouth. It had a bitter, coppery taste from the headlamp.“That's awright. Don't worry about it. I'll put you on another one.”Ezra could be a demanding teacher, but he was also practical. Razzing me wasn't going to put more frogs in the boat. There were ... Author, Article, and Disclosure InformationAffiliations: The Johns Hopkins University School of Medicine Baltimore, MD 21236Corresponding Author: Samuel C. Durso, MD, Johns Hopkins Geriatrics at White Marsh, 4924 Campbell Boulevard, Suite 205, Baltimore, MD 21236; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLife on the Receiving End: A Qualitative Analysis of Health Providers??? Illness Narratives 17 December 2002Volume 137, Issue 12Page: 1004-1005KeywordsHeartHeart failureMarshesMosquitoesMouthShouldersSurgeonsSweatTasteWilderness ePublished: 17 December 2002 Issue Published: 17 December 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Roentgenographic Study of 7 Cancers Developed on Stumps from Gastrectomy for Ulcers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update
Authors: Nasser Hanna, David Johnson, Sarah Temin, Sherman Baker, Julie Brahmer, Peter M. Ellis, Giuseppe Giaccone, Paul J. Hesketh, Ishmael Jaiyesimi, Natasha B. Leighl, Gregory J. Riely, Joan H. Schiller, Bryan J. Schneider, Thomas J. Smith, Joan Tashbar, William A. Biermann, Gregory Masters
Journal: Journal of Clinical Oncology (2017)

Purpose Provide evidence-based recommendations updating the 2015 ASCO guideline on systemic therapy for patients with stage IV non-small-cell lung cancer (NSCLC). Methods The ASCO NSCLC Expert Panel made recommendations based on a systematic review of randomized controlled trials from February 2014 to December 2016 plus the Cancer Care Ontario Program in Evidence-Based Care's update of a previous ASCO search. Results This guideline update reflects changes in evidence since the previous guideline update. Fourteen randomized controlled trials provide the evidence base; earlier phase trials also informed recommendation development. Recommendations New or revised recommendations include the following. Regarding first-line treatment for patients with non-squamous cell carcinoma or squamous cell carcinoma (without positive markers, eg, EGFR/ALK /ROS1), if the patient has high programmed death ligand 1 (PD-L1) expression, pembrolizumab should be used alone; if the patient has low PD-L1 expression, clinicians should offer standard chemotherapy. All other clinical scenarios follow 2015 recommendations. Regarding second-line treatment in patients who received first-line chemotherapy, without prior immune checkpoint therapy, if NSCLC tumor is positive for PD-L1 expression, clinicians should use single-agent nivolumab, pembrolizumab, or atezolizumab; if tumor has negative or unknown PD-L1 expression, clinicians should use nivolumab or atezolizumab. All immune checkpoint therapy is recommended alone plus in the absence of contraindications. For patients who received a prior first-line immune checkpoint inhibitor, clinicians should offer standard chemotherapy. For patients who cannot receive immune checkpoint inhibitor after chemotherapy, docetaxel is recommended; in patients with nonsquamous NSCLC, pemetrexed is recommended. In patients with a sensitizing EGFR mutation, disease progression after first-line epidermal growth factor receptor tyrosine kinase inhibitor therapy, and T790M mutation, osimertinib is recommended; if NSCLC lacks the T790M mutation, then chemotherapy is recommended. Patients with ROS1 gene rearrangement without prior crizotinib may be offered crizotinib, or if they previously received crizotinib, they may be offered chemotherapy.