tbuckley/cabot-search huggingface dataset:
PAVEMENTS AND DISEASE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glycogen Stored in Skeletal but Not in Cardiac Muscle in Acid α-Glucosidase Mutant (Pompe) Mice Is Highly Resistant to Transgene-Encoded Human Enzyme
Authors: N RABEN, T JATKAR, A LEE, N LU, S DWIVEDI, K NAGARAJU, P PLOTZ
Journal: Molecular Therapy (2002)

Although many lysosomal disorders are corrected by a small amount of the missing enzyme, it has been generally accepted that 20–30% of normal acid α-glucosidase (GAA) activity, provided by gene or enzyme replacement therapy, would be required to reverse the myopathy and cardiomyopathy in Pompe disease. We have addressed the issue of reversibility of the disease in the Gaa–/– mouse model. We have made transgenic lines expressing human GAA in skeletal and cardiac muscle of Gaa–/– mice, and we turned the transgene on at different stages of disease progression by using a tetracycline-controllable system. We have demonstrated that levels of 20–30% of normal activity are indeed sufficient to clear glycogen in the heart of young Gaa–/– mice, but not in older mice with a considerably higher glycogen load. However, in skeletal muscle—a major organ affected in infantile and in milder, late-onset variants in humans—induction of GAA expression in young Gaa–/– mice to levels greatly exceeding wildtype values did not result in full phenotypic correction, and some muscle fibers showed little or no glycogen clearance. The results demonstrate that complete reversal of pathology in skeletal muscle or long-affected heart muscle will require much more enzyme than previously expected or a different approach.
Acute meningoencephalitis. Association with isoniazid administration
Authors: V. F. Garagusi
Journal: JAMA (1976)

MENINGITIS from drug hypersensitivity is a rare phenomenon.<sup>1</sup>The, following case report illustrates the occurrence of severe aseptic purulent meningoencephalitis in a patient who had received prophylactic isoniazid therapy. <h3>Report of a Case</h3> A 27-year-old man was hospitalized on Jan 4, 1974, because of fever, chills, myalgia, arthralgia, nausea, vomiting, and severe generalized headache. In August 1973, pleuritic chest pain— thought to be of viral origin—developed. Results of a physical examination and a chest x-ray film were normal. An intermediate purified protein derivative test was again positive (10 mm of induration), as it had been since 1967. Prophylactic isoniazid therapy was initiated with a dose of 300 mg/day. After three days of treatment, fever, weakness, malaise, nausea, and vomiting developed. Findings of a physical examination and liver function studies were normal. When isoniazid therapy was discontinued, the patient rapidly recovered. In December 1973, while in good health and receiving
Asymptomatic Gonorrhea
Authors: John Raba
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The report by John J. Potterat and Richard D. King, MD, and the editorial by A. Eugene Washington, MD (1981;245:578, 609) indicated that fully asymptomatic men may be a substantial hidden reservoir of gonorrhea. This report is entirely consistent with a recent screening of 737 consecutive men admitted to the Cook County jail. All were questioned about past history of gonorrhea and present history of dysuria or a urethral discharge. Urethral cultures using calcium alginate swabs on flexible aluminum shafts were taken for all of the men admitted. The percentage of men that had positive Thayer-Martin cultures for gonorrhea was 5.2%. Not a single one of these patients had complained of dysuria or a urethral discharge in spite of direct questioning. On examination and urethral milking, 32.1% of those with positive gonorrhea cultures were found to have discharges. The elicited discharge was generally whitish and watery—more consistent
First Antibiotic Treatment to Reduce the Risk of Duodenal Ulcer Recurrence
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recovery after prolonged asystolic cardiac arrest in profound hypothermia. A case report and literature review
Authors: F. S. Southwick
Journal: JAMA (1980)

Asystole can be the presenting ECG finding in accidental hypothermia when the core temperature is less than 28 °C. Even two hours of persistent asystole does not represent irreversible cardiac compromise. With cardiopulmonary support and active rewarming, resuscitation and survival without serious sequelae can be achieved. Case reports and electrophysiology studies suggest that asystole is a primary manifestation of hypothermia potentiated by carbon dioxide retention. However, ventricular fibrillation in this setting is probably a secondary complication of resuscitation efforts, being precipitated by hypocapnic alkalosis, physical manipulation of the heart, and rewarming. (<i>JAMA</i>243:1250-1253, 1980)
Clinical Diagnosis. Case Examination and the Analysis of Symptoms.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diclofenac-associated hepatotoxicity
Authors: S. M. Helfgott
Journal: JAMA (1990)

Diclofenac sodium, a phenylacetic acid—derived nonsteroidal anti-inflammatory drug (NSAID) recently released in the United States, was associated with the development of significant hepatitis in seven patients, with one associated death. Signs and symptoms developed within several weeks of initiation of drug use and generally resolved 4 to 6 weeks following discontinuation of use of the drug. The only patient rechallenged with the drug developed a recurrence of her hepatic abnormalities. In one patient, fatal, fulminant hepatitis developed despite early withdrawal of the drug. Review of the European literature disclosed three additional fatalities associated with diclofenac therapy. It is unclear whether the incidence of hepatotoxicity is higher with this drug compared with other nonsteroidal anti-inflammatory drugs. Careful patient monitoring is advised, and prompt discontinuation of the drug is suggested when signs or symptoms of liver disease develop. (<i>JAMA</i>. 1990;264:2660-2662)
Observations on the Morbid Anatomy, Pathology, and Determining Cause of Emphysema of the Lungs
Authors: A. T. H. Waters
Journal: BMJ (1860)

Dwm 8s low]ORIGINAL OXXUNICATIONL.(hizmom He had two or tlr liquid Il.eaeuations dung the say, and ws not worse at, night.He had taken pain-doses of quinine, with an effervescent ammonia miture, during the day.Nov. B0th.He took two alomel and opium pills in the night, on account of restlessaess.He bad only one small liquid motion during the night.The abdomen was more tender, and more generally distended.The countenance was dejected.The pulse was weak, but not more rapid than yesterday.He lhad no sickness.We determined to apply turpentine stupes
Effect of an active magnetometer on permanently implanted pacemakers
Authors: N. P. Smyth
Journal: JAMA (1972)

Fifty-three patients with permanently implanted pacemakers, predominantly of the triggered unipolar variety, were exposed to the active electromagnetic field of a weapons detector. Standard unipolar and bipolar ventricular pacers were unaffected. Certain sensitive unipolar atrial and atrioventricular pacers showed minor temporary rate changes that were clinically insignificant. We believe that the weapons detector can be safely employed with patients who have any of the pacemakers tested.
Erratum for the Research Article: “P-selectin is a nanotherapeutic delivery target in the tumor microenvironment” by Y. Shamay, M. Elkabets, H. Li, J. Shah, S. Brook, F. Wang, K. Adler, E. Baut, M. Scaltriti, P. V. Jena, E. E. Gardner, J. T. Poirier, C. M. Rudin, J. Baselga, A. Haimovitz-Friedman, D. A. Heller
Journal: Science Translational Medicine (2018)
Preliminary Studies on the Toxicity and Metabolism of Palladium and Platinum
Authors: W. Moore, D. Hysell, L. Hall, K. Campbell, J. Stara
Journal: Environmental Health Perspectives (1975)

Preliminary data are given on the LD50 of PdCl2 following different routes of exposure and on the LD50 of PtCl4 following intravenous exposure. The retention, tissue distribution, and excretion of 103Pd and 191Pt in rats was determined following oral, intravenous, intratracheal, and inhalation exposure. The highest retention for both 103Pd and 191Pt was obtained following intravenous dosing, and the lowest retention occurred after oral dosing. Following a single oral dose, almost all of the 103Pd and 191Pt was excreted in the feces due to nonabsorption, whereas after intravenous dosing, similar quantities were excreted in both the urine and feces. Tissues containing the highest concentrations of these metals were the kidney, spleen and liver. Following intravenous dosing of pregnant rats, a small amount of 103Pd and 191Pt was found in the fetuses.
"CREDULITY AND CURES"
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A case-control study of spermicides and gonorrhea
Authors: H. Austin
Journal: JAMA (1984)

A case-control study was done to evaluate the effectiveness of vaginal spermicides as a prophylaxis against gonorrhea. The subjects included 735 women with gonorrhea and 958 controls seen in a sexually transmitted disease clinic. The relative risk (RR) of gonorrhea for spermicide users compared with nonusers was 0.67 with 90% confidence limits, 0.44 to 1.0. This RR was 0.47 (90% confidence limits, 0.25 to 0.87) after the exclusion of women using oral contraceptives, an intrauterine device, or with a tubal ligation. The protective effect of spermicides was confined largely to women who had also used diaphragms or whose partners had used condoms. The RR of gonorrhea for spermicide and condom users relative to nonusers of spermicides, condoms, and diaphragms was 0.41 (90% confidence limits, 0.21 to 0.79), while for spermicide and diaphragm users, this RR was 0.45 (90% confidence limits, 0.15 to 1.3). These results suggest that a woman can appreciably decrease her risk of contracting gonorrhea if she uses spermicides in conjunction with either the diaphragm or the condom. (<i>JAMA</i>1984;251:2822-2824)
Canadian Journal of Biochemistry, Ottawa
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy
Authors: Ian G. Cannell, Karl A. Merrick, Sandra Morandell, Chang-Qi Zhu, Christian J. Braun, Robert A. Grant, Eleanor R. Cameron, Ming-Sound Tsao, Michael T. Hemann, Michael B. Yaffe
Journal: Cancer Cell (2015)
MEDICAL ORGANIZATION AND THE REORGANIZED NEW YORK STATE MEDICAL ASSOCIATION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictors and outcome of early allograft dysfunction (EAD) following orthotopic liver transplantation (OLT) JR Lake, R Krom, S Belle and the NIDDK Liver Transplantation Database. University of California, San Francisco, Mayo Clinic and University of Pittsburgh, Pittsburgh, PA
Journal: Hepatology (1995)

Orthotopic liver transplantation (OLT) is an effective treatment for patients who have end-stage liver disease. The aim of this study is to compare outcomes of OLT in fulminant hepatic failure (FHF) and non-fulminant hepatic failure (non-FHF) patients.A retrospective review of adult patients who underwent OLT for non-malignant end-stage liver diseases between 2002 and 2011 at Siriraj Hospital was performed. All explanted liver histopathology results were reviewed. The clinical factors and overall results of OLT were analyzed.Of the 137 patients, 72 patients had non-malignant diagnoses. Eleven patients were diagnosed with FHF, whereas 61 patients were in the non-FHF group. The most common indication for liver transplantation was chronic viral hepatitis. One- and 5-year survival rates (95% confidence interval) in the FHF group were 91% (51%–99%) and 91% (51%–99%), respectively, whereas those in the non-FHF group were 74% (61%–83%) and 66% (52%–77%), respectively. Multivariate cox regression analysis revealed no statistically significant difference of survival between both groups (P = .34).The post-OLT outcomes in non-malignant patients were comparable between FHF and non-FHF groups in terms of survival. OLT remains the only therapeutic option for the FHF patients.
What are we teaching about indigent patients?
Authors: S. H. Miles
Journal: JAMA (1992)

AN ADULT woman without health insurance presented to the emergency department of a private, not-for-profit, university hospital. A male acquaintance had assaulted her and had fractured her forearm. After the assault, she impulsively took an overdose of an anticonvulsant, phenytoin. A friend brought her to the emergency department. Because a history of intravenous drug abuse had scarred the patient's peripheral veins, peripheral intravenous access was not possible. An attempt to place a catheter in her subclavian vein led to a pneumothorax and a chest tube. Intravenous access was then obtained through a jugular vein. As the overdose was an emergency, the arm was splinted and she was admitted to the medicine service on which I was the attending physician. Two days later, she was medically stabilized. The overdose was resolved, the chest tube was pulled. A psychiatrist concluded that the overdose was in response to the stress of the assault
Crossing Over
Authors: Rishi Raj
Journal: JAMA (1997)

Mr Luis Gomez in ICU bed 6 had hemophilia. As I put in the central line, I was thinking of the fact that despite all the new treatments for HIV, he was still losing the battle. He had once told me that he believed he and his twin brother, Jose, were lucky because they did not have to bleed to death like countless other persons with hemophilia before them. Though the factor VIII that had kept them from bleeding had also infected both twins with HIV, they did not seem to dwell on it anymore, almost as if this were their destiny, their fate. Now, here he was, Luis, the frailer twin, in the ICU with pneumococcal sepsis and multiorgan failure, tubes with bloody collars entering and leaving his body, machines beeping all around him. I often wondered what Jose thought as he stood by the bed in this technological
Look Out for Malignant Hyperthermia
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal