tbuckley/cabot-search huggingface dataset:
Single, high dose intramuscular triamcinolone acetonide versus weekly oral methotrexate in life-threatening asthma: a double blind study.
Authors: D Vervloet, D Charpin
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

"Single, high dose intramuscular triamcinolone acetonide versus weekly oral methotrexate in life-threatening asthma: a double blind study.." American journal of respiratory and critical care medicine, 153(6), pp. 1989–1990
Intentional Overdose by Intravaginal Insertion of Lithium Carbonate
Authors: Linda MacGorman
Journal: JAMA (1994)

<h3>To the Editor.</h3> —A 48-year-old woman with bipolar disorder and a history of borderline personality disorder and previous suicide attempts presented to an outlying emergency department, having recently vomited. She admitted to the ingestion, 60 minutes earlier, of 97 lithium carbonate tablets (immediate release, 300 mg each). Her vital signs were stable. Initial physical examination was normal except for mild lethargy and decreased patellar reflexes. An electrocardiogram showed mild T-wave flattening. Complete blood cell count and urinalysis were normal; a serum toxicology screen was negative except for lithium. Serum potassium was decreased at 3.3 mmol/L and serum lithium was 4.3 mmol/L. Gastric lavage revealed pill fragments. After stabilization, the patient was transported to our medical center's intensive care unit. On arrival the serum lithium level was 3.1 mmol/L. Potassium supplementation was provided along with intravenous fluids. Lithium levels rose to 3.5 mmol/L, and hemodialysis was instituted, resulting in a decrease
Letter: Lavatory doors.
Authors: B Nakra, R Gaind
Journal: BMJ (1973)

decision to reduce the birth rate, irrespective of -the consequences such *masures may have on the life dt an individual.When ad- vising procedures wvhich "penranently" deny procreation, it is important that the physician be -not carried away with his own enthusiasm for the operation and by his public-spiritedness.The paramount concern, as always, should be the future happiness and emotional stability of his patient.-Weare, etc.,
Abstract PR7: Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor-resistance in EML4-ALK lung cancer cells
Authors: Seiji Yano, Shinji Takeuchi, Takayuki Nakagawa, Tadaaki Yamada
Journal: Clinical Cancer Research (2012)

Abstract Cancer cell microenvironments, including host cells, can critically affect cancer cell behaviors, including drug sensitivity. We recently reported that hepatocyte growth factor (HGF), the ligand of a tyrosine kinase receptor Met, can be produced not only by cancer cells but also host fibroblasts, activates Met and the downstream PI3K/Akt pathway and triggers resistance to EGFR inhibitors in EGFR mutant lung cancer cells (Yano S et al, Cancer Res, 2008). Crizotinib, a dual inhibitor of ALK and Met, shows dramatic effects against EML4-ALK lung cancer cells, but these cells can acquire resistance by several mechanisms, including ALK amplification and gatekeeper mutation. Although elective ALK inhibitors can overcome crizotinib resistance due to these mechanisms, these cells may become resistant to these inhibitors. Here, we determined whether microenvironmental factors trigger ALK inhibitor resistance in EML4-ALK lung cancer cells. We tested the effects of ligands produced by endothelial cells and fibroblasts, and the cells themselves, on the susceptibility of EML4-ALK lung cancer cell lines to crizotinib and TAE684, a selective ALK inhibitor active against cells with ALK amplification and gatekeeper mutations, both in vitro and in vivo. EML4-ALK lung cancer cells were highly sensitive to ALK inhibitors. EGFR ligands, such as EGF, TGF-α, and HB-EGF, activated EGFR and triggered resistance to crizotinib and TAE684 by transducing bypass survival signaling through Erk1/2 and Akt. HGF activated Met/Gab1 and triggered resistance to TAE684, but not crizotinib, which inhibits Met. Endothelial cells and fibroblasts, which produce the EGFR ligands and HGF, respectively, decreased the sensitivity of EML4-ALK lung cancer cells to crizotinib and TAE684, respectively. EGFR-TKIs re-sensitized these cells to crizotinib and Met-TKI to TAE684 even in the presence of EGFR ligands and HGF, respectively. Our findings suggest that paracrine receptor activation by ligands from the microenvironment may trigger resistance to ALK inhibitors in EML4-ALK lung cancer cells, and provide a rationale for targeting receptor ligands in the microenvironment for more successful treatment with ALK inhibitors. These observation further raise clinical questions which classes ALK inhibitors are more beneficial for EML4-ALK lung cancer patients. This proffered talk is also presented as Poster A30.
Basic Pathology
Authors: Robert W. McDivitt
Journal: JAMA (1982)

Dr Vinay Kumar joins Drs Stanley Robbins and Marcia Angell as author of this third edition of<i>Basic Pathology</i>. The book is 694 pages in length, a reflection of the authors' desire to keep it thin so that it may serve as a basic text for medical and dental students and paramedical personnel. The text is divided into two parts, the first 234 pages being devoted to general pathology, the remainder organized according to the organ system approach. When compared with the second edition, the book appears to have been extensively revised and includes new chapters on genetic diseases, disorders of immunity, and nutritional disorders. The quality of illustrations is generally good, although the paper used in this printing does not seem to lend itself as well to high-quality illustrations as that used in other Saunders publications. Perhaps this was done as an economy measure. Tables and figures appropriately complement
Abstract 16830: Early Cardiac Biomarker Changes Following Myocardial Injury
Authors: Marilee Fisher, Toyoaki Maruta, Takeshi Yano, Tian Li, Jay McQuillan, Adam Setren, Jane Blood, Jeremiah J Morrissey, Isao Tsuneyoshi, Richard G Bach, Walter A Boyle
Journal: Circulation (2015)

Introduction: Levels of cardiac troponin I (cTnI), now used routinely to identify myocardial infarction, typically rise slowly following an acute myocardial injury (AMI), and early detection remains challenging, as does early identification of large AMI events that may benefit most from early invasive management. Methods and Results: Plasma samples were obtained preceding and at frequent intervals following septal myocardial ablation (PTSMA) in HCM patients (n = 20) to identify putative early cardiac biomarkers (CBs). Immunoassays for CBs of interest were developed and validated. Three CBs with markedly different time-dependent profiles following AMI were identified (Figure 1): cTnI rose slowly and peaked late (16-24h); fatty acid binding protein 3 (FABP3) rose and peaked much earlier (4-6h); while myosin light chain 3 (MYL3) peaked and declined very rapidly (&lt;2h). Quantification of time-dependent changes in the levels of CBs, d[CB]/dt and d2[CB]/dt2, revealed dynamic early signals with the potential to time the onset and course of injury (Figure 2). Conclusions: These data demonstrate significantly different time courses for increased plasma levels of CBs following an AMI event. While cTnI is the most cardiac specific, MYL3 and FABP3 levels, as well as changes in levels of all 3 CBs, provide additional early information that may allow for improved ability to diagnose AMI at earlier time points, as well as to identify time elapsed since the AMI event. Such analyses of novel CBs and their rapid changes may enhance early identification of AMI and help distinguish larger AMIs that could benefit most from early intervention.
Military medicine undertakes peacetime mission, aiding in processing those fleeing from Haiti
Authors: P. Gunby
Journal: JAMA (1994)

AS HAITIANS take to the sea by the thousands in an attempt to gain refuge in the United States, US military medicine once again is being called upon to undertake an unusual mission. By the end of this month, according to some projections, as many as 100000 persons may flee from the reported terrorism of Haitian army officials who ousted the elected president in a coup 34 months ago, from the widespread poverty in Haiti, or in response to the Clinton administration's refugee policy, which is viewed in some quarters as being more liberal than previously. Perhaps 12 000 of these persons will be placed in temporary quarters on the US naval base at Guantánamo Bay, Cuba. Beginning with the setting up of the 50-bed 6th Air Transportable Hospital from MacDill Air Force Base (AFB), Tampa, Fla, at Guantánamo Bay, US military medicine has been scrambling to meet the sudden
Commentaire du travail de Albert JG et al., pp. 857
Journal: Endoscopy (2014)

See also: A novel, stiff-shaft, flexible-tip guidewire for cannulation of biliary stricture during endoscopic retrograde cholangiopancreatography: a randomized trialEndoscopy 2014; 46(10): 857-861DOI: 10.1055/s-0034-1377628
Primer on allergic and immunologic diseases. Prepared by the American Academy of Allergy and Immunology
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Prevention of Insanity.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BERLIN LETTER.
Authors: None H. R. B.
Journal: JAMA (1884)

Berlin, Nov. 18, 1884. <h3>Gynæcology.</h3> —Dr. Schroeder admits no one to his laparotomies without an especial invitation. The person invited is requested to bathe thoroughly before coming, and to wear a suit of clothes which has been aired, and which has not been in general use. I saw him make a gastro-hysterectomy at half-past seven on the morning of the 15th (most of the operative work is done here in the early morning). The operation lasted one hour and three-quarters, and varied in no essential particular from the routine which I have already described in the<i>American Journal of Obstetrics</i>. The actual cautery was used to the stump, and a 10 per cent, solution of carbolic acid was made use of. The stump was well protected by its flaps, so that there was no oozing, and it was then dropped into the cavity. The professor is most ably seconded by
Difficult Problem.—
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Wyatt W. Decker, Ronna L. Campbell, Veena Manivannan, Anuradha Luke, Jennifer L. St. Sauver, Amy Weaver, M. Fernanda Bellolio, Eric J. Bergstralh, Latha G. Stead, James T.C. Li
Journal: Journal of Allergy and Clinical Immunology (2009)
Foramen magnum tumors. Pitfalls in diagnosis
Authors: J. R. Howe
Journal: JAMA (1973)

Six patients with benign tumors near the foramen magnum underwent many months of inappropriate medical, surgical, and chiropractic therapy. The lesions were misdiagnosed as multiple sclerosis, syringomyelia, ruptured disc, cervical spondylosis, and several other conditions. Four of the six patients had myelograms that did not demonstrate the tumors. The complex anatomy of the cervicomedullary junction partially explains the difficulty in diagnosis. A coexistent lesion or history of trauma may divert the physician's attention away from the cervicomedullary junction. Other pitfalls include the following: a history of remission and exacerbation, a positive response to inappropriate or nonspecific therapy, and the frequent finding of a normal cerebrospinal fluid protein value. Surgical removal of foramen magnum tumors can be curative.
Bridging the Gap
Authors: C. L. Cope
Journal: BMJ (1966)

<h3>Background</h3> Policy simulation models (PSMs) have been used extensively to shape health policies before real-world implementation and evaluate post-implementation impact. This systematic review aimed to examine best practices, identify common pitfalls in tobacco control PSMs and propose a modelling quality assessment framework. <h3>Methods</h3> We searched five databases to identify eligible publications from July 2013 to August 2019. We additionally included papers from Feirman <i>et al</i> for studies before July 2013. Tobacco control PSMs that project tobacco use and tobacco-related outcomes from smoking policies were included. We extracted model inputs, structure and outputs data for models used in two or more included papers. Using our proposed quality assessment framework, we scored these models on population representativeness, policy effectiveness evidence, simulated smoking histories, included smoking-related diseases, exposure-outcome lag time, transparency, sensitivity analysis, validation and equity. <h3>Findings</h3> We found 146 eligible papers and 25 distinct models. Most models used population data from public or administrative registries, and all performed sensitivity analysis. However, smoking behaviour was commonly modelled into crude categories of smoking status. Eight models only presented overall changes in mortality rather than explicitly considering smoking-related diseases. Only four models reported impacts on health inequalities, and none offered the source code. Overall, the higher scored models achieved higher citation rates. <h3>Conclusions</h3> While fragments of good practices were widespread across the reviewed PSMs, only a few included a ‘critical mass’ of the good practices specified in our quality assessment framework. This framework might, therefore, potentially serve as a benchmark and support sharing of good modelling practices.
Contraction of smooth muscle with blood of patients with ulcers
Authors: A. N. Geisel
Journal: JAMA (1970)

The blood of patients with duodenal or gastric ulcer confirmed by x-ray film was tested on a strip of guinea pig ileum. The height of contraction of the ileum as well as the latent period are expressed as the ratio between these two values and the contraction and latent period to 1μg of serotinin creatine sulfate. In about 90% (116) of the group with peptic ulcer, contractions were high and latent periods were short as compared with normal controls in whom there were no or small contractions and prolonged latent periods. Chemistry and origin of this factor are being investigated.
A DNA methylation-based classifier for accurate molecular diagnosis of bone sarcomas.
Authors: Shengyang Wu, Benjamin Thomas Cooper, Fang Bu, Christopher Bowman, Keith Killian, Jonathan Serrano, Shiyang Wang, Twana Jackson, Daniel Gorovets, Richard Greg Gorlick, Marc Ladanyi, Kristen Thomas, Matija Snuderl, Matthias A. Karajannis
Journal: Journal of Clinical Oncology (2017)

11034 Background: Bone sarcomas present a unique diagnostic challenge because of the considerable morphologic overlap between different entities. The choice of optimal treatment, however, is dependent upon accurate diagnosis. Genome-wide DNA methylation profiling has emerged as a new approach to aid in the diagnosis of brain tumors, with diagnostic accuracy exceeding standard histopathology. In this work we developed and validated a methylation based classifier to differentiate between osteosarcoma, Ewing’s sarcoma, and synovial sarcoma. Methods: DNA methylation status of 482,421 CpG sites in 15 osteosarcoma, 10 Ewing’s sarcoma, and 11 synovial sarcoma samples were measured using the Illumina HumanMethylation450 array. From this training set of 36 samples we developed a random forest classifier using the 400 most differentially methylated CpG sites (FDR q value &lt; 0.001). This classifier was then validated on 10 synovial sarcoma samples from TCGA, 86 osteosarcoma samples from TARGET-OS, and 15 Ewing’s sarcoma from a recently published series (Huertas-Martinez et al., Cancer Letters 2016). Results: Methylation profiling revealed three distinct molecular clusters, each enriched with a single sarcoma subtype. Within the validation cohorts, all samples from TCGA were correctly classified as synovial sarcoma (10/10, sensitivity and specificity 100%). All but one sample from TARGET-OS were classified as osteosarcoma (85/86, sensitivity 98%, specificity 100%) and all but one sample from the Ewing’s sarcoma series was classified as Ewing’s sarcoma (14/15, sensitivity 93%, specificity 100%). The single misclassified osteosarcoma sample was classified as Ewing’s sarcoma, and was later determined to be a misdiagnosed Ewing’s sarcoma based on RNA-Seq demonstrating high EWRS1 and ETV1 expression. An additional clinical sample that was misdiagnosed as a synovial sarcoma by initial histolopathology, was accurately recognized as osteosarcoma by the methylation classifier. Conclusions: Osteosarcoma, Ewing’s sarcoma and synovial sarcoma have distinct epigenetic profiles. Our validated methylation-based classifier can be used to provide an accurate diagnosis when histological and standard techniques are inconclusive.
Alterations in Peripheral Blood Flow Consequent to Maximal Exercise
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal