Nephrogenic Diabetes Insipidus
Authors: Jeff M. Sands, Daniel G. Bichet
Journal: Annals of Internal Medicine (2006)

Reviews7 February 2006Nephrogenic Diabetes InsipidusJeff M. Sands, MD and Daniel G. Bichet, MDJeff M. Sands, MDFrom Emory University School of Medicine, Atlanta, Georgia, and Université de Montréal, Montréal, Québec, Canada. and Daniel G. Bichet, MDFrom Emory University School of Medicine, Atlanta, Georgia, and Université de Montréal, Montréal, Québec, Canada.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-3-200602070-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Clinical PrinciplesPatients with diabetes insipidus produce large quantities of dilute urine.Diabetes insipidus can result from failure of the posterior pituitary to make or secrete vasopressin (antidiuretic hormone) or end-organ (kidney) insensitivity.Patients with congenital nephrogenic diabetes insipidus now live well into adulthood and need to be followed by internists to avoid bladder dysfunction, renal dysfunction, and complications related to inaccessibility to water.Optimal therapy for nephrogenic diabetes insipidus involves drinking enough water to avoid dehydration, which can be difficult in patients at the extremes of age.Additional therapy includes a very low-sodium diet, thiazide diuretics, and indomethacin.Exogenous vasopressin is not useful because the ...References1. Sands JM, Gargus JJ, Fröhlich O, Gunn RB, Kokko JP. Urinary concentrating ability in patients with Jk(a-b-) blood type who lack carrier-mediated urea transport. J Am Soc Nephrol. 1992;2:1689-96. [PMID: 1498276] CrossrefMedlineGoogle Scholar2. Zerbe RL, Robertson GL. A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria. N Engl J Med. 1981;305:1539-46. [PMID: 7311993] CrossrefMedlineGoogle Scholar3. Sands JM, Layton HE. Urine concentrating mechanism and its regulation.. In: Seldin DW, Giebisch G, eds. The Kidney: Physiology and Pathophysiology. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2000:1175-216. Google Scholar4. Kokko JP, Rector FC. Countercurrent multiplication system without active transport in inner medulla. Kidney Int. 1972;2:214-23. [PMID: 4657922] CrossrefMedlineGoogle Scholar5. Stephenson JL. Concentration of urine in a central core model of the renal counterflow system. Kidney Int. 1972;2:85-94. [PMID: 4671532] CrossrefMedlineGoogle Scholar6. Sands JM, Knepper MA. Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium. J Clin Invest. 1987;79:138-47. [PMID: 3793921] CrossrefMedlineGoogle Scholar7. Sands JM, Nonoguchi H, Knepper MA. Vasopressin effects on urea and H2O transport in inner medullary collecting duct subsegments. Am J Physiol. 1987;253:F823-32. [PMID: 3688238] MedlineGoogle Scholar8. Brown D. The ins and outs of aquaporin-2 trafficking. Am J Physiol Renal Physiol. 2003;284:F893-901. [PMID: 12676734] CrossrefMedlineGoogle Scholar9. Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev. 2002;82:205-44. [PMID: 11773613] CrossrefMedlineGoogle Scholar10. Forssman H. On the mode of hereditary transmission in diabetes insipidus. Nordisk Medicine. 1942;16:3211-3. Google Scholar11. Waring AG, Kajdi L, Tappan V. Congenital defect of water metabolism. Am J Dis Child. 1945;69:323-5. Google Scholar12. Williams RM, Henry C. Nephrogenic diabetes insipidus transmitted by females and appearing during infancy in males. Ann Intern Med. 1947;27:84-95. LinkGoogle Scholar13. Fujiwara TM, Morgan K, Bichet DG. Molecular biology of diabetes insipidus. Annu Rev Med. 1995;46:331-43. [PMID: 7541187] CrossrefMedlineGoogle Scholar14. Morello JP, Bichet DG. Nephrogenic diabetes insipidus. Annu Rev Physiol. 2001;63:607-30. [PMID: 11181969] CrossrefMedlineGoogle Scholar15. Knoers NV, Deen PM. Molecular and cellular defects in nephrogenic diabetes insipidus. Pediatr Nephrol. 2001;16:1146-52. [PMID: 11793119] CrossrefMedlineGoogle Scholar16. van Lieburg AF, Knoers NV, Monnens LA. Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus. J Am Soc Nephrol. 1999;10:1958-64. [PMID: 10477148] CrossrefMedlineGoogle Scholar17. Hoekstra JA, van Lieburg AF, Monnens LA, Hulstijn-Dirkmaat GM, Knoers VV. Cognitive and psychosocial functioning of patients with congenital nephrogenic diabetes insipidus. Am J Med Genet. 1996;61:81-8. [PMID: 8741926] CrossrefMedlineGoogle Scholar18. McIlraith CH. Notes on some cases of diabetes insipidus with marked family and hereditary tendencies. Lancet. 1892;2:767-8. CrossrefGoogle Scholar19. Kamsteeg EJ, Wormhoudt TA, Rijss JP, van Os CH, Deen PM. An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus. EMBO J. 1999;18:2394-400. [PMID: 10228154] CrossrefMedlineGoogle Scholar20. Aridor M, Balch WE. Integration of endoplasmic reticulum signaling in health and disease. Nat Med. 1999;5:745-51. [PMID: 10395318] CrossrefMedlineGoogle Scholar21. Bichet DG, Bouvier M, Brouard R, Morello JP, Bernier V, Lonergan M, et al. Decrease in urine volume and increase in urine osmolality after SR49059 administration in five male adult patients with X-linked nephrogenic diabetes insipidus [Abstract]. J Am Soc Nephrol. 2002;13:40A. Google Scholar22. Deen PM, Croes H, vanAubel RA, Ginsel LA, van Os CH. Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes insipidus are impaired in their cellular routing. J Clin Invest. 1995;95:2291-6. [PMID: 7537761] CrossrefMedlineGoogle Scholar23. Mulders SM, Knoers NV, Van Lieburg AF, Monnens LA, Leumann E, Wühl E, et al. New mutations in the AQP2 gene in nephrogenic diabetes insipidus resulting in functional but misrouted water channels. J Am Soc Nephrol. 1997;8:242-8. [PMID: 9048343] CrossrefMedlineGoogle Scholar24. Mulders SM, Bichet DG, Rijss JP, Kamsteeg EJ, Arthus MF, Lonergan M, et al. An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex. J Clin Invest. 1998;102:57-66. [PMID: 9649557] CrossrefMedlineGoogle Scholar25. Tamarappoo BK, Verkman AS. Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones. J Clin Invest. 1998;101:2257-67. [PMID: 9593782] CrossrefMedlineGoogle Scholar26. van Os CH, Deen PM. Aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus. Proc Assoc Am Physicians. 1998;110:395-400. [PMID: 9756089] MedlineGoogle Scholar27. Kuwahara M, Iwai K, Ooeda T, Igarashi T, Ogawa E, Katsushima Y, et al. Three families with autosomal dominant nephrogenic diabetes insipidus caused by aquaporin-2 mutations in the C-terminus. Am J Hum Genet. 2001;69:738-48. [PMID: 11536078] CrossrefMedlineGoogle Scholar28. Marr N, Bichet DG, Lonergan M, Arthus MF, Jeck N, Seyberth HW, et al. Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus. Hum Mol Genet. 2002;11:779-89. [PMID: 11929850] CrossrefMedlineGoogle Scholar29. Peters M, Jeck N, Reinalter S, Leonhardt A, Tönshoff B, Klaus GG, et al. Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies. Am J Med. 2002;112:183-90. [PMID: 11893344] CrossrefMedlineGoogle Scholar30. Schlingmann KP, Konrad M, Jeck N, Waldegger P, Reinalter SC, Holder M, et al. Salt wasting and deafness resulting from mutations in two chloride channels. N Engl J Med. 2004;350:1314-9. [PMID: 15044642] CrossrefMedlineGoogle Scholar31. Bichet DG, Fujiwara TM. Reabsorption of sodium chloride—lessons from the chloride channels. N Engl J Med. 2004;350:1281-3. [PMID: 15044637] CrossrefMedlineGoogle Scholar32. Jeck N, Reinalter SC, Henne T, Marg W, Mallmann R, Pasel K, et al. Hypokalemic salt-losing tubulopathy with chronic renal failure and sensorineural deafness. Pediatrics. 2001;108:5. [PMID: 11433084] CrossrefMedlineGoogle Scholar33. Reinalter SC, Jeck N, Brochhausen C, Watzer B, Nüsing RM, Seyberth HW, et al. Role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome. Kidney Int. 2002;62:253-60. [PMID: 12081585] CrossrefMedlineGoogle Scholar34. Gallucci E, Micelli S, Lippe C. Non-electrolyte permeability across thin lipid membranes. Arch Int Physiol Biochim. 1971;79:881-7. [PMID: 4112719] MedlineGoogle Scholar35. Wieth JO, Funder J, Gunn RB, Brahm J. Passive transport pathways for chloride and urea through the red cell membrane.. In: Bolis K, Bloch K, Luria SE, Lynen F, eds. Comparative Biochemistry and Physiology of Transport. Amsterdam: Elsevier/North-Holland; 1974:317-37. Google Scholar36. Bagnasco SM. Gene structure of urea transporters. Am J Physiol Renal Physiol. 2003;284:F3-10. [PMID: 12473534] CrossrefMedlineGoogle Scholar37. Sands JM. Molecular mechanisms of urea transport. J Membr Biol. 2003;191:149-63. [PMID: 12571750] CrossrefMedlineGoogle Scholar38. Sands JM. Mammalian urea transporters. Annu Rev Physiol. 2003;65:543-66. [PMID: 12524463] CrossrefMedlineGoogle Scholar39. Sands JM. Molecular approaches to urea transporters. J Am Soc Nephrol. 2002;13:2795-806. [PMID: 12397052] CrossrefMedlineGoogle Scholar40. Olivès B, Mattei MG, Huet M, Neau P, Martial S, Cartron JP, et al. Kidd blood group and urea transport function of human erythrocytes are carried by the same protein. J Biol Chem. 1995;270:15607-10. [PMID: 7797558] CrossrefMedlineGoogle Scholar41. Olivès B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, et al. Molecular characterization of a new urea transporter in the human kidney. FEBS Lett. 1996;386:156-60. [PMID: 8647271] CrossrefMedlineGoogle Scholar42. Lucien N, Sidoux-Walter F, Olivès B, Moulds J, Le Pennec PY, Cartron JP, et al. Characterization of the gene encoding the human Kidd blood group/urea transporter protein. Evidence for splice site mutations in Jknull individuals. J Biol Chem. 1998;273:12973-80. [PMID: 9582331] CrossrefMedlineGoogle Scholar43. Sidoux-Walter F, Lucien N, Nissinen R, Sistonen P, Henry S, Moulds J, et al. Molecular heterogeneity of the Jk(null) phenotype: expression analysis of the Jk(S291P) mutation found in Finns. Blood. 2000;96:1566-73. [PMID: 10942407] CrossrefMedlineGoogle Scholar44. Lucien N, Sidoux-Walter F, Roudier N, Ripoche P, Huet M, Trinh-Trang-Tan MM, et al. Antigenic and functional properties of the human red blood cell urea transporter hUT-B1. J Biol Chem. 2002;277:34101-8. [PMID: 12093813] CrossrefMedlineGoogle Scholar45. Edwards A, Pallone TL. Facilitated transport in vasa recta: theoretical effects on solute exchange in the medullary microcirculation. Am J Physiol. 1997;272:F505-14. [PMID: 9140052] MedlineGoogle Scholar46. Edwards A, Pallone TL. A multiunit model of solute and water removal by inner medullary vasa recta. Am J Physiol. 1998;274:H1202-10. [PMID: 9575923] MedlineGoogle Scholar47. Pallone TL, Turner MR, Edwards A, Jamison RL. Countercurrent exchange in the renal medulla. Am J Physiol Regul Integr Comp Physiol. 2003;284:R1153-75. [PMID: 12676741] CrossrefMedlineGoogle Scholar48. Ranade K, Wu KD, Hwu CM, Ting CT, Pei D, Pesich R, et al. Genetic variation in the human urea transporter-2 is associated with variation in blood pressure. Hum Mol Genet. 2001;10:2157-64. [PMID: 11590132] CrossrefMedlineGoogle Scholar49. Timmer RT, Sands JM. Lithium intoxication. J Am Soc Nephrol. 1999;10:666-74. [PMID: 10073618] CrossrefMedlineGoogle Scholar50. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med. 1994;97:383-9. [PMID: 7942943] CrossrefMedlineGoogle Scholar51. Boton R, Gaviria M, Batlle DC. Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy. Am J Kidney Dis. 1987;10:329-45. [PMID: 3314489] CrossrefMedlineGoogle Scholar52. Christensen S, Kusano E, Yusufi AN, Murayama N, Dousa TP. Pathogenesis of nephrogenic diabetes insipidus due to chronic administration of lithium in rats. J Clin Invest. 1985;75:1869-79. [PMID: 2989335] CrossrefMedlineGoogle Scholar53. Cogan E, Svoboda M, Abramow M. Mechanisms of lithium-vasopressin interaction in rabbit cortical collecting tubule. Am J Physiol. 1987;252:F1080-7. [PMID: 3109254] MedlineGoogle Scholar54. Goldberg H, Clayman P, Skorecki K. Mechanism of Li inhibition of vasopressin-sensitive adenylate cyclase in cultured renal epithelial cells. Am J Physiol. 1988;255:F995-1002. [PMID: 2461098] MedlineGoogle Scholar55. Batlle DC, von Riotte AB, Gaviria M, Grupp M. Amelioration of polyuria by amiloride in patients receiving long-term lithium therapy. N Engl J Med. 1985;312:408-14. [PMID: 3969096] CrossrefMedlineGoogle Scholar56. Marples D, Christensen S, Christensen EI, Ottosen PD, Nielsen S. Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla. J Clin Invest. 1995;95:1838-45. [PMID: 7535800] CrossrefMedlineGoogle Scholar57. Klein JD, Gunn RB, Roberts BR, Sands JM. Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats. Kidney Int. 2002;61:995-1002. [PMID: 11849454] CrossrefMedlineGoogle Scholar58. Michimata M, Mizukami K, Suzuki M, Kazama I, Nakamura Y, Suzuki K, et al. Vasopressin-independent renal urinary concentration: increased rBSC1 and enhanced countercurrent multiplication. Kidney Int. 2003;64:933-8. [PMID: 12911543] CrossrefMedlineGoogle Scholar59. Nielsen J, Kwon TH, Praetorius J, Kim YH, Frøkiaer J, Knepper MA, et al. Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI. Am J Physiol Renal Physiol. 2003;285:F1198-209. [PMID: 12928314] CrossrefMedlineGoogle Scholar60. Frøkiaer J, Marples D, Knepper MA, Nielsen S. Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. Am J Physiol. 1996;270:F657-68. [PMID: 8967344] MedlineGoogle Scholar61. Sands JM, Flores FX, Kato A, Baum MA, Brown EM, Ward DT, et al. Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats. Am J Physiol. 1998;274:F978-85. [PMID: 9612337] MedlineGoogle Scholar62. Marples D, Frøkiaer J, Dørup J, Knepper MA, Nielsen S. Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. J Clin Invest. 1996;97:1960-8. [PMID: 8621781] CrossrefMedlineGoogle Scholar63. Sands JM, Naruse M, Jacobs JD, Wilcox JN, Klein JD. Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet. J Clin Invest. 1996;97:2807-14. [PMID: 8675692] CrossrefMedlineGoogle Scholar64. Frøkiaer J, Christensen BM, Marples D, Djurhuus JC, Jensen UB, Knepper MA, et al. Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction. Am J Physiol. 1997;273:F213-23. [PMID: 9277582] MedlineGoogle Scholar65. Earm JH, Christensen BM, Frøkiaer J, Marples D, Han JS, Knepper MA, et al. Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats. J Am Soc Nephrol. 1998;9:2181-93. [PMID: 9848772] CrossrefMedlineGoogle Scholar66. Amlal H, Krane CM, Chen Q, Soleimani M. Early polyuria and urinary concentrating defect in potassium deprivation. Am J Physiol Renal Physiol. 2000;279:F655-63. [PMID: 10997915] CrossrefMedlineGoogle Scholar67. Jung JY, Madsen KM, Han KH, Yang CW, Knepper MA, Sands JM, et al. Expression of urea transporters in potassium-depleted mouse kidney. Am J Physiol Renal Physiol. 2003;285:F1210-24. [PMID: 12952854] CrossrefMedlineGoogle Scholar68. Li C, Klein JD, Wang W, Knepper MA, Nielsen S, Sands JM, et al. Altered expression of urea transporters in response to ureteral obstruction. Am J Physiol Renal Physiol. 2004;286:F1154-62. [PMID: 14982816] CrossrefMedlineGoogle Scholar69. Rowe JW, Shock NW, DeFronzo RA. The influence of age on the renal response to water deprivation in man. Nephron. 1976;17:270-8. [PMID: 951013] CrossrefMedlineGoogle Scholar70. Sporn IN, Lancestremere RG, Papper S. Differential diagnosis of oliguria in aged patients. N Engl J Med. 1962;267:130-2. [PMID: 13915895] CrossrefMedlineGoogle Scholar71. O'Neill PA, McLean KA. Water homeostasis and ageing. Med Lab Sci. 1992;49:291-8. [PMID: 1339933] MedlineGoogle Scholar72. Preisser L, Teillet L, Aliotti S, Gobin R, Berthonaud V, Chevalier J, et al. Downregulation of aquaporin-2 and -3 in aging kidney is independent of V(2) vasopressin receptor. Am J Physiol Renal Physiol. 2000;279:F144-52. [PMID: 10894796] CrossrefMedlineGoogle Scholar73. Combet S, Teillet L, Geelen G, Pitrat B, Gobin R, Nielsen S, et al. Food restriction prevents age-related polyuria by vasopressin-dependent recruitment of aquaporin-2. Am J Physiol Renal Physiol. 2001;281:F1123-31. [PMID: 11704564] CrossrefMedlineGoogle Scholar74. Trinh-Trang-Tan MM, Geelen G, Teillet L, Corman B. Urea transporter expression in aging kidney and brain during dehydration. Am J Physiol Regul Integr Comp Physiol. 2003;285:R1355-65. [PMID: 12933359] CrossrefMedlineGoogle Scholar75. Swenson KL, Sands JM, Jacobs JD, Sladek CD. Effect of aging on vasopressin and aquaporin responses to dehydration in Fischer 344-brown-Norway F1 rats. Am J Physiol. 1997;273:R35-40. [PMID: 9249530] MedlineGoogle Scholar76. Catudioc-Vallero J, Sands JM, Sidorowicz HE, Klein JD, Sladek CD. Effect of age and testosterone on the vasopressin response to dehydration in F344BNF1 male rats. Adv Exp Med Biol. 1998;449:183-5. [PMID: 10026802] CrossrefMedlineGoogle Scholar77. Combet S, Geffroy N, Berthonaud V, Dick B, Teillet L, Verbavatz JM, et al. Correction of age-related polyuria by dDAVP: molecular analysis of aquaporins and urea transporters. Am J Physiol Renal Physiol. 2003;284:F199-208. [PMID: 12388383] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jeff M. Sands, MD; Daniel G. Bichet, MDAffiliations: From Emory University School of Medicine, Atlanta, Georgia, and Université de Montréal, Montréal, Québec, Canada.Acknowledgments: The authors thank Danielle Binette for providing graphical expertise.Grant Support: By National Institutes of Health grants R01-DK41707, R01-DK63657, and P01-DK61521 (Dr. Sands) and by the Canadian Institutes of Health Research (MOP81581) and the Kidney Foundation of Canada (Dr. Bichet). Dr. Bichet also holds a Canada Research Chair in Genetics of Renal Diseases.Disclosures: None disclosed.Corresponding Author: Jeff M. Sands, MD, Renal Division, Emory University School of Medicine, 1639 Pierce Drive, NE, WMB Room 338, Atlanta, GA 30322; e-mail, jeff.sands@emory.edu.Current Author Addresses: Dr. Sands: Renal Division, Emory University School of Medicine, 1639 Pierce Drive, NE, WMB Room 338, Atlanta, GA 30322.Dr. Bichet: Department of Medicine and Groupe d'étude des protéines membranaires, Université de Montréal, Research Center, Hôpital du Sacré-Coeur de Montréal, 5400 Boulevard Gouin West, Montréal, Québec H4J 1C5, Canada. 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