tbuckley/cabot-search huggingface dataset:
Diagnosis of pneumoconiosis
Authors: F. H. Green
Journal: JAMA (1981)

<h3>In Reply.—</h3> It is apparent that Green and associates have failed to receive the message delivered by our recent study. The data indicate that there is a substantial overlap in the incidence of those microscopic features that have been heretofore regarded as inviolable evidence of CWP in the lungs of coal miners and urban dwellers. Dr Green and associates fail to indicate in what manner the selection of the two populations would detract from the conclusion rendered. According to them, one might conclude that a large segment of the urban population exhibits pulmonary changes warranting a diagnosis of CWP. That such persons or that all miners suffer from such a disease is not supported by clinical, radiological, or other evidence. What then is there about the identical changes encountered in the lungs of coal miners that prompts Dr Green and associates to intimate that these changes in lungs of coal
Intracranial suppuration secondary to trauma. Infection with Nocardia asteroides
Authors: D. M. Poretz
Journal: JAMA (1975)

INTRACRANIAL suppuration is a potential complication of infection caused by<i>Nocardia asteroides</i>. When the central nervous system is involved by this process, hematogenous dissemination from a pulmonary focus is assumed to have occurred, although this is not always possible to prove. Traumatic nocardial infection has been reported but is extremely unusual. This is a case report of a patient who sustained an injury to the head that eventually led to an infection caused by<i>Nocardia asteroides</i>. <h3>Report of a Case</h3> A 36-year-old, healthy construction worker was admitted to The Fairfax Hospital on Dec 26, 1972, because of an injury sustained at work when he was struck in the face by a metal wedge. He suffered a trimallar fracture on the left side and had violation of the left maxillary and ethmoidal sinuses. At surgery, it was noted that there was destruction to part of the left frontal lobe and that
Residency Overwork
Authors: Richard M. Hamrick
Journal: Annals of Internal Medicine (1996)

Letters15 May 1996Residency OverworkRichard M. Hamrick III, MDRichard M. Hamrick III, MDPulmonary Associates of Richmond; Richmond, VA 23229Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the recent article about residency overwork by Dr. Green [1] and the accompanying editorial by Dr. Griner [2]. Both review the debate that has continued since the Libby Zion case. Very little discussion has addressed the number of hours worked by physicians in private practice.I practice with a 14-person pulmonary and critical care group. It is typical for us to work between 80 and 100 hours in some weeks, and during certain stretches we may have only 1 or 2 days off in a month. My colleagues in cardiology and cardiothoracic surgery ...References1. Green M. What (if anything) is wrong with residency overwork? Ann Intern Med. 1995; 123:512-7. Google Scholar2. Griner P. Residency overwork and changing paradigms of service [Editorial]. Ann Intern Med. 1995; 123:547-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Pulmonary Associates of Richmond; Richmond, VA 23229 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1996Volume 124, Issue 10Page: 932KeywordsCardiothoracic surgeryCritical careFatigueResidencySleepSub-specialty care Issue Published: 15 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
What's wrong with the funding of cancer research?
Authors: P. Hugh-Jones
Journal: BMJ (1982)

age of 70 where histological diagnosis may occasionally be difficult, for in the eighth to tenth decades many senile plaques without neurofibrillary tangles may occasionally be present in demented subjects, and this finding, though uncommon, is found in some nondemented individuals.At any age, however, numerous neurofibrillary tangles in the neocortex are restricted to the demented population, so the biopsy diagnosis of Alzheimer's disease is possible in the great majority of cases at any age.Cerebral biopsy is not justified in this disorder more because of ethical reasons and lack of effective therapy rather than difficulties with interpreting the neuro- pathology.
Nutritional Assessment
Authors: Karen Miller Kovach
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The COMMENTARY "Nutritional Assessment" (1980;244:559) reflects the growing awareness within the medical profession of the importance nutritional status can have in a patient's clinical course. There are, however, two points not touched on that warrant some discussion. It is our contention that without clarification of these areas, the contents could be misinterpreted and, more important, misused by the general practitioner. The first area deals with the simple screening method presented. It is agreed that the procedure can be effective, particularly in assessing the patient who is hypermetabolic or facing major surgery. However, undue reliance on this tool can screen out a substantial number of persons whose poor nutriture is secondary to a chronic underingestion of food energy. For example, of the last 20 patients admitted to this institution for treatment of anorexia nervosa, none exhibited hypoalbuminemia, and only 20% had depressed total lymphocyte counts. This becomes
PROSPECTUS
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute tubular necrosis in a renal transplant recipient. Complication from drip-infusion excretory urography
Authors: J. A. Light
Journal: JAMA (1975)

HISTORICALLY, the chief technical problem in renal transplantation has been the reconstruction of the urinary tract.<sup>1</sup>For this reason, we have performed routine drip-infusion excretory urography in the early posttransplantation period, as soon as renal function became adequate to permit visualization of the collecting system and ureter. Thus, small leaks masked by catheter drainage might be detected and repaired prior to catheter removal and clinical manifestations. Furthermore, the differential diagnosis of subsequent oliguria would be simplified by knowing that the urinary tract was anatomically normal. These studies had been performed in more than 40 patients and were thought to be harmless until the experience cited in this brief article was encountered. <h3>Report of a Case</h3> A 24-year-old woman with a history of chronic glomerulonephritis since childhood had been undergoing hemodialysis for one year prior to receiving a kidney transplant from her 44-year-old father. An uncomplicated transplantation was performed in
Journal of Nuclear Medicine, Chicago
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 457: HER2, AR protein expression and chromosomal instability in circulating tumor cells (CTCs) of metastatic breast cancer (MBC) patients (pts)
Authors: Priscilla Ontiveros, Connie Landaverde, Maren K. Levin, Sarah Hippely, Mark Landers, Yipeng Wang, Ryan Dittamore, Joyce A. O'Shaughnessy
Journal: Cancer Research (2019)

Abstract Background: Upregulation of HER2 and AR protein expression, and increase in chromosomal instability, are mechanisms of acquired resistance to endocrine therapy, and are being investigated as treatment-guiding biomarkers. However, measurement of these biomarkers requires metastatic biopsies, which are costly, invasive, and prone to under-sampling which precludes their utility to guide treatment in late stage metastatic pts. A CTC-based test could expand the clinical utility. Using the Epic Sciences platform, MBC blood samples were characterized for CTC prevalence, HER2 and AR expression on CTCs, and CTC chromosomal instability at time of disease progression. Material and methods: Blood samples were acquired from 127 total pts with HR+/HER2-, HR-/HER2+ and TNBC metastatic breast cancer pts. 114 samples were analyzed for HER2 and 110 were analyzed for AR using the Epic CTC Platform. Single-cell whole genome sequencing was performed on 157 CTCs from 19 pts to assess large scale transitions (a surrogate of chromosome instability) and gene copy number alterations. Results: 87/114 (76.3%) of pts had detectable CTCs, with a median of 1.1 CTC/mL. 17/114 (14.9%) had at least one HER2(+) CTC, 21/110 (19.1%) had at least one AR(+) CTC, and 10/110 (9%) had both AR(+) and HER2(+) CTCs detected in technical replicates. HER2 expression on individual CTCs showed distinctive cytoplasmic membrane staining, and AR expression on individual CTCs showed frequent nuclear localization. The majority of HER2+ and AR+ CTCs had high cytokeratin expression. Most pt samples showed heterogeneous expression of these markers at disease progression indicating subclonal sensitivity to targeted therapies. CTCs with larger nuclear area and higher N/C ratio had higher frequency of chromosomal instability. ERBB2, FGFR1 gain, PTEN, CDH1, BRCA1, BRCA2 loss were frequently observed and the prevalence were associated with CTC phenotypes. Conclusions: CTCs are detected in most MBC pts upon disease progression. CTC based biomarkers assessing HER2, AR and chromosomal instability status could guide therapy selection. The results warrant prospective evaluation of these biomarkers on MBC pts’ CTCs as a resistance marker for targeted therapies. Citation Format: Priscilla Ontiveros, Connie Landaverde, Maren K. Levin, Sarah Hippely, Mark Landers, Yipeng Wang, Ryan Dittamore, Joyce A. O'Shaughnessy. HER2, AR protein expression and chromosomal instability in circulating tumor cells (CTCs) of metastatic breast cancer (MBC) patients (pts) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 457.
Psychiatry
Authors: Jack D. Barchas
Journal: JAMA (1996)

Exciting research in neuroimaging, genetics, and psychopharmacology and advances in basic neuroscience and psychosocial fields continue to invigorate psychiatry. Several new findings have challenged some of our notions about the pathophysiological mechanisms underlying psychiatric disorders. At the same time, inadequate research funding in areas such as childhood and adolescent mental disorders and major shifts in the financing of mental health care will profoundly affect the way psychiatry is practiced through the end of the century. Brain imaging modalities are advancing our understanding of fundamental neuroanatomic mechanisms associated with schizophrenia, one of the most devastating of psychiatric illnesses. [See also Radiology.—Ed.] By using innovative techniques to scan transient behavioral events rapidly, Silbersweig et al<sup>1</sup>at the Hammersmith Hospital, London, England, have provided visual maps that indicate the neuroanatomic substrate of hallucinations in schizophrenic patients. Positron emission tomography was used to measure changes in blood flow in the brains of
Hair casts or pseudonits
Authors: S. R. Kohn
Journal: JAMA (1977)

CONSIDERING both the increasing incidence and the increasing clinical awareness of pediculosis capitis, it is surprising that since 1961, when Rollins<sup>1</sup>reported three cases of hair casts (peripilar keratin casts), or pseudonits, there have been, to my knowledge, no additional reports of this entity mentioned in the North American literature. Hair casts, or pseudonits, are 2-to 7-mm long, discrete, firm, shiny, white, freely movable tubular accretions that encircle the hair shafts of the scalp. Hair casts may be due to the persistence of the inner root sheath of the hair, which normally crumbles or is digested at the sebaceous gland opening (Fig 1 and 2). The misdiagnosis of hair casts as pediculosis capitis or nits may have severe psychological or physiological consequences for the patients and their families. <h3>Report of a Case</h3> A 7-year-old girl was seen in consultation following a five-year history of having nits repeatedly diagnosed by
A insuficiència coronária (estudo semiológico)
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary Cutaneous Follicular Lymphoma: An Assessment of Clinical, Histopathologic, Immunophenotypic, and Molecular Features
Authors: I. Mirza, N. Macpherson, S. Paproski, R. D. Gascoyne, B. Yang, W. G. Finn, E. D. Hsi
Journal: Journal of Clinical Oncology (2002)

Unlike nodal follicular lymphoma (NFL), Primary cutaneous follicular lymphomas (PCFLs) rarely express Bcl-2 protein or t(14;18)(q32;q21) (Bcl-2/IgH). The aim of this study was to further characterize PCFL in a large series from North America.Clinical data and archival formalin-fixed, paraffin-embedded tissue were obtained from 32 patients. PCFL was defined as follicular lymphoma limited to the skin at the time of diagnosis and within the first 6 months after diagnosis. Specimens were analyzed for the expression of CD3, CD10, CD20, Bcl-2, and Bcl-6 proteins by immunohistochemistry as well as for the presence of t(14;18)(q32;q21) by polymerase chain reaction.The male-to-female ratio was 1.5:1, with a median age of 60 years. Twenty-four patients had lesions on the head and neck, five had lesions on the trunk, and three had lesions on both head and trunk. Follow-up data were available in all cases, with a mean length of 35.8 months. The majority of the patients were treated with radiation therapy. All patients were alive at last follow-up except one. Recurrence was noted in seven patients (22%), after a mean disease-free survival time of 17.7 months. CD10 and Bcl-6 expression were seen in 29 (91%) of 32 and 31 (97%) of 32 cases, respectively. Bcl-2 expression was noted in 13 (41%) of 32 cases. PCR results for t(14;18)(q32;q21) were positive in 11 (34%) of 32 patients and showed correlation with Bcl-2 protein expression. The sequencing of the t(14;18)(q32;q21) amplicons confirmed unique breakpoints in each of the seven tested cases. Comparison between the Bcl-2 and/or t(14;18)(q32;q21)-positive and t(14;18)(q32;q21)-negative cases revealed no significant difference in age, site, clinical course, or outcome.We demonstrated Bcl-2 protein expression and t(14;18)(q32;q21) in a significant minority of cases, suggesting a relationship with NFL. It remains to be seen whether, on longer follow-up, there is any clinical difference in cases with and without t(14;18)(q32;q21).
<i>Lectures on Auto-Intoxication in Disease, or Self-Poisoning of the Individual.</i>By Ch. Bouchard, Professor of Pathology and Therapeutics, Member of the Academy of Medicine, and Physician to the Hospitals, Paris. Translated, with a Preface, by Thomas Oliver, M. A., M. D., F.R.C.P., Professor of Physiology, University of Durham; Physician to the Royal Infirmary, Newcastle-upon-Tyne; and Examiner in Physiology, Conjoint Board of England. In one Octavo volume; 302 pages. Extra cloth, $1.75 net…
Authors: W. C. G.
Journal: American Journal of Psychiatry (1894)
Miscellany.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Typographical Error in Article
Journal: JAMA Psychiatry (2014)

Ceren Akdeniz, MSc; Heike Tost, MD, PhD; Fabian Streit, MSc; Leila Haddad, MSc; Stefan Wüst, PhD; Axel Schäfer, PhD; Michael Schneider, MD; Marcella Rietschel, MD, PhD; Peter Kirsch, PhD; Andreas Meyer-Lindenberg, MD, PhD
Booknote
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Annals of Internal Medicine, Philadelphia
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parabiotic resuscitation in profound cardiovascular failure. Experimental results in canine hemorrhagic shock
Authors: L. R. Bryant
Journal: JAMA (1967)

Irreversibles an enigma in experimental animals and in man. Much work has been done in an effort to elucidate the pathophysiological changes which characterize the state of "irreversibility" so that specific therapy may be directed at these disturbances. Even though irreversible shock cannot be defined as precisely in man as in the dog, it seems likely that the basic metabolic consequences of prolonged shock are similar in both species. The differences in the pathological manifestations of shock between man and experimental animals seem related to differences in susceptibility of various organs to the hemodynamic changes of shock. Lillehei<sup>1</sup>has proposed a unified concept in which the stage of irreversibility, whether induced by hemorrhage, bacterial endotoxins, or myocardial failure, is characterized by loss of tone in precapillary arterial sphincters while postcapillary sphincters remain constricted. The result is a progressive loss of plasma from the vascular system, stagnant anoxia and congestion