tbuckley/cabot-search huggingface dataset:
Availability of Parenteral Isoniazid—United States
Journal: JAMA (1993)

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The Trapeze
Authors: Susan Holway
Journal: JAMA (1988)

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NECROLOGY.
Authors: None J. B. E.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ECG Challenge: September 10, 2013
Authors: Philip Podrid
Journal: Circulation (2013)

A 67-year-old man with new-onset heart failure is seen in the hospital and is started on therapy with an angiotensin-converting enzyme inhibitor, a β-blocker, furosemide, and spironolactone.One week later, he presents with weakness, nausea, and lightheadedness.His blood urea nitrogen and creatinine are significantly elevated to 62/2.8 compared with 24/1.3 at baseline.An ECG is obtained.
Abstract 3112: Slower Periodic VO <sub>2</sub> Oscillations during Exercise Indicate Worse Clinical Status and Poorer Prognosis of Patients with Heart Failure
Authors: Motoaki Ibuki, Hiroshi Takaki, Shogo Oishi, Takuya Taniguchi, Rika Kawakami, Teruo Noguchi, Yoichi Goto, Masaru Sugimachi
Journal: Circulation (2008)

Purpose: It is generally assumed that the cycle length (CL) of periodic VE or VO 2 oscillation, an ominous sign seen during exercise in advanced heart failure (HF), is approximately one minute. However, in our experience, the duration seems to vary substantially among individuals, and the differences in CL may be of clinical and prognostic value. We hypothesized that CL varies substantially among patients with HF and that slower oscillations indicate worse clinical status and prognosis. Methods: From a consecutive series of over 4500 symptom-limited bicycle exercise tests with respiratory gas analysis performed for recent 5.5 years, we selected 50 patients (LVEF = 31 ± 13%) with HF exhibiting the most marked exercise VO 2 oscillations that allowed us to accurately measure CL. The patient selection were made by our developed FFT method estimating the ratio of low-frequency power (0.5–1.25 cycle/min) relative to total power (4-min time-window, overlapping every 30sec). After averaging CL of at least 3 periodic VO 2 fluctuations for each patient, patients were evenly divided into two groups according to the median of CL: Group-S (Slower, longer CL, n=25) and Group-F (Faster, shorter CL, n=25). Demographic, clinical, prognostic, and exercise data were compared between the groups. Results: We found that CL substantially varied from 45 to 118 sec (median = 67 sec). CL of Group-S was 80 ± 11 sec, while that of Group-F was 59 ± 6 sec. There was no significant difference with respect to age, sex, and etiology of HF between the groups. Compared with Group-F, Group-S showed lower peak VO 2 (15.4 ± 3.6 vs 18.6 ± 4.2 ml/min/kg, p=0.005) and oxygen pulse (7.4 ± 2.5 vs 9.5 ± 2.1 ml, p=0.002), and greater VE/VCO 2 slope (42 ± 12 vs 37 ± 8, p=0.049). Group-S also had higher BNP level (457 ± 348 vs 256 ± 275 pg/ml, p=0.03). Kaplan-Meier mortality rates for cardiac and all-cause death were significantly higher in Group-S than in Group-F (both, p&lt;0.05). Conclusions: We demonstrated that cycle length of exercise VO 2 oscillations substantially varies among patients with heart failure, and that the difference is of clinical significance; the slower the cycle length, the worse the clinical status and prognosis.
Effect of nifedipine on bronchomotor tone and histamine reactivity in asthma.
Journal: BMJ (1981)

it is difficult to explain how successful resuscitation is possible after 40 minutes' submersion.2The reduced oxygen requirement in profound hypothermia has been suggested by some authors as the mechanism by which tissue viability is maintained in these circumstances,2 but this alone is an incomplete explanation, as for the submerged body to cool to a degree at which oxygen requirements are sufficiently reduced, heat transfer by mass flow-that is, circulation -must be present (a dead body cools relatively slowly).The degree of cooling encountered in our cases can be explained only by the fact that circulation was maintained for some or all of the period of submersion.The persistence of cardiac activity during such a pro- longed period of apnoea supports the hypothesis that some protective mechanism may be present.We do not know whether ventricular fibrillation was present before resuscitative efforts were started and must concede that these efforts alone may have initiated the arrhythmia.Our cases show yet again that successful resuscitation is possible after long periods of immersion and emphasise the importance of performing electrocardiography early in the immersion incident, preferably at the accident site, before death is pronounced.
Reaction of Alveolar Macrophages to Inhaled Metal Aerosols
Authors: Per Camner, Anne Johansson
Journal: Environmental Health Perspectives (1992)

For more than a decade we have exposed rabbits to different metals, usually in soluble form, and investigated the effects on the lungs. The metal concentrations have been around 1 mg/m3,i.e., not more than a factor of 10 above occupational threshold limit values. The exposure periods have been 1-8 months (6 hr/day, 5 days/week). We have studied especially the morphology and function of alveolar macrophages (AM), the morphology of alveolar type I and type II epithelial cells, and analyzed lung phospholipids. Several metals produce specific, complex effects. For example, metallic and soluble nickel (NiCl2) increase both number and size of the type II cells, increase the production of surfactant, and affect morphology and function of AM. Cobalt (CoCl2) induces a different effect on type II cells from nickel, causing the formation of nodules in these cells. Trivalent chromium [Cr(NO3)3] does not affect either type II cells or the amount of surfactant significantly, but markedly affects AM. The administered metals affect AM both directly and indirectly. For example, nickel induces an increased production of surfactant, resulting in overfed AM with an increased metabolic activity. However, nickel also induces a direct decrease in the release of lysozyme activity by AM. Our results emphasize the complexity of the effects on the lungs of inhaled agents, which can act both directly and indirectly on AM.
Tenth Annual Report of the State Board of Health of the State of Ohio for the year ending Oct. 31, 1895.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Correction
Authors: Md Griffiths, W Adams, Philip Harris, J Abercrombie, London Addiscott, B Addy, D Aitken, R Anderson, C Aitken, J Arnott, Rev Brooks, B Bull, Gottingen Blackstein, Mrs Behnke, W Clapham, A Coldstream, Florence Cumberland, A Churchill, ; Cowan, W Calvert, A Dimmock, R Dove
Journal: BMJ (1898)

f Queries, answers, and communications relating to subjects to whic special department. of the BRITISH M1EDICAL JOuIRNAL are drected wiU be found under their respective headings.4UIERIES. DR. BOND (Gloucester
DIGITALIS MEDICATION
Authors: Harold E. B. Pardee
Journal: JAMA (1926)

<h3>To the Editor:</h3> —I was much interested to receive the criticism of my recent paper on digitalis medication. The critic is certainly quite right in saying that the method of testing digitalis is one which has not yet been perfected so as to permit definite conclusions from a therapeutic standpoint. On the other hand, I have had considerable occasion to check it and I have found it satisfactory. I am not sure as to what Sahli and Kottman meant when they referred to full therapeutic action and clinical effect. It is not likely that they meant the same thing that I would mean if they have obtained it after 2 cc. or 3 cc. of digalen. I am unfamiliar with and cannot find the literature to which reference is made. My own experience shows that there is a great difference between the activity of 30 minims and 120 minims when
A HIGHER STANDARD OF ENTRANCE TO OHIO MEDICAL SCHOOLS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic and predictive blood-based biomarkers of overall survival (OS) in patients (pts) with advanced colorectal cancer (CRC) treated with cetuximab (C): Results from CALGB 80203 (Alliance).
Authors: Ace Joseph Hatch, Herbert Pang, Mark D. Starr, John C. Brady, Jingquan Jia, Chen Jiang, Alexander Sibley, Kouros Owzar, Donna Niedzwiecki, Alan P. Venook, Stephanie M. Cushman, Herbert Hurwitz, Andrew B. Nixon
Journal: Journal of Clinical Oncology (2014)

11022 Background: Previously, we identified potential predictive biomarkers of C sensitivity related to EGFR signaling from archived tumor tissue from CALGB 80203. Due to the fact that blood-based markers are more convenient and can be monitored over the course of treatment, baseline plasma samples were also collected and five (EGF, HB-EGF, sEGFR, sHER2, sHER3) markers were evaluated in plasma. Methods: CALGB 80203 was a randomized (1:1) phase II trial of 238 pts with locally advanced or metastatic CRC comparing FOLFOX or FOLFIRI (chemo) vs. chemo plus C. Baseline EDTA plasma samples from 154 pts were analyzed for the five candidate markers; an ELISA for CD73 is currently being optimized for use. The levels of each analyte were correlated with the primary endpoint of OS using univariate Cox proportional hazards models. Potential predictive markers were identified using a treatment by marker interaction term in the Cox model and the markers with significant p-values are reported. Hazard ratios between treatment groups are reported for low or high marker levels dichotomized at the median. Results: Univariate analyses indicated that plasma levels of EGF and sHER3 were negative prognostic markers (p<0.05) that correlated with OS for the overall pt population. Across all pts (KRAS mutant and wild-type), sHER3 was identified as a potential predictive biomarker for C. Pts with higher sHER3 levels had significant OS benefit from C treatment (interaction p=0.03; HR=0.57, 95% CI 0.36-0.92). Low levels of EGF predicted for OS benefit from C in KRAS WT tumors (interaction p<0.01; HR=0.42, 95% CI 0.19-0.90) and lack of benefit in the KRAS mutant pts (interaction p=0.03; HR=2.69, 95% CI 1.04-6.94), but were not predictive for C across all pts. Conclusions: Blood-based profiling of EGFR axis members identified sHER3 and EGF as candidate predictors for benefit from C. These data are consistent with our findings using mRNA expression from archived tumor samples and suggest a role for receptor shedding in HER3 biology. If further validated, these markers may help guide the development and use of anti-EGFR therapies and combination regimens.
Tufts University Medical School Center explores genetic defenses of bacteria, cancer cells
Authors: A. A. Skolnick
Journal: JAMA (1993)

RESEARCHERS AT the Center for Adaptation Genetics and Drug Resistance at Tufts University Medical School, Boston, Mass, are out to outfox the defense systems of bacteria and cancer cells. According to its director, Stuart B. Levy, MD, professor of medicine and of molecular biology and microbiology, the newly opened center is unique in being devoted to the study of genes and gene products that are called into play by bacteria and mammalian cells when exposed to growth inhibitory agents and other environmental stresses. The multidisciplinary center currently has 18 researchers with expertise in molecular biology, genetics, nucleic acid and protein biochemistry, membrane transport, pharmacology, physiology, oncology, and infectious diseases. Their efforts are divided into four areas: tetracycline resistance, regulation of multidrug resistance in bacteria, multidrug resistance in cancer cells, and the development of soil bacteria for cleaning up toxic wastes. The alarming increase in the incidence of multidrug-resistant bacteria underscores
Highlights
Journal: JAMA (2017)

Rates of surgical site infection after removal of orthopedic implants have been unexpectedly high.In a trial of 470 patients who were undergoing removal of orthopedic implants, Manouk and colleagues found that a single preoperative dose of intravenous cefazolin, compared with saline, did not reduce this risk. CME jamanetwork.com/learning Mortality Risk of Short-term Exposure to Air Pollution 2446US air quality standards are periodically reevaluated in light of new scientifi c evidence.Di and colleagues conducted a case-crossover study of more than 22 million deaths in the US Medicare population and found that short-term exposures to fi ne particulate matter and ozone were associated with mortality at levels below current standards.In an Editorial, Zhang recommends cleaner energy production to reduce ambient emissions and suggests that personalized protection strategies may decrease individual susceptibility.
ETIOLOGY, PATHOLOGY AND TREATMENT OF CYSTS OF THE JAWS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiphasic health testing
Authors: D. J. Lehman
Journal: JAMA (1977)

MULTIPHASIC health testing was called to the attention of American medicine in 1972 by the Department of Community Health of the American Medical Association. It consists of collecting specimens from humans and reporting test results—an incomplete health service. Periodic health appraisal in medical practices, schools, certain businesses, and industry has been recommended by physicians for many years. Particularly important were the cases of cancer, diabetes, glaucoma, and unsuspected cardiovascular disease which were discovered in persons who thought they were in excellent health. This form of testing involves fixed units, such as physicians' offices, testing centers, or mobile units capable of doing certain screening tests. The importance of physicians' evaluation and interpretation of test results has been emphasized and in no way replaces diagnosis and treatment by the physician. Recently multiphasic health testing centers have been opening, usually by business people, at a national rate of two a week in urban
IMMUNOLOGIC EVIDENCE AS TO THE EVOLUTIONARY RELATIONSHIPS OF MAN
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adjuvant Radiation for Stage II-B Soft Tissue Sarcoma of the Extremity
Authors: Kaled M. Alektiar, Dennis Leung, Michael J. Zelefsky, Murray F. Brennan
Journal: Journal of Clinical Oncology (2002)

Adjuvant radiation therapy (RT) has been shown to improve local control in patients with high-grade soft tissue sarcoma (STS) of the extremity. This study sought to define the optimal management in patients with stage II-B (high-grade, size < or = 5 cm) tumors.Between July 1982 and December 1998, 204 adult patients with primary stage II-B STS underwent limb-sparing surgery with negative microscopic margins. Eighty-eight patients (43%) received RT; 116 (57%) did not. The RT and no-RT groups were balanced with regard to age, site (upper v lower extremity), whether patients had prior unplanned excision, and location (central, i.e., shoulder/groin v non-central). The RT group had more deep tumors (P =.03). Adjuvant RT was delivered with brachytherapy in 60% and external-beam radiation in 40% of patients.With a median follow-up of 67 months, the 5-year local control, distant relapse-free survival, and disease-specific survival rates were 82%, 80%, and 88%, respectively. There was no significant difference in local control between the RT and no-RT groups (84% v 80%, respectively, P =.3). Tumor depth, site, and prior unplanned excision did not correlate with local control. The only independent predictors of poor local control were central tumor location (relative risk [RR] = 3; 95% confidence interval [CI], 2 to 7; P =.005) and age more than 50 years (RR = 6; 95% CI, 2 to 13; P =.001).In this retrospective study, adjuvant RT did not significantly improve local control in patients with stage II-B STS of the extremity. The outcome of patients with central tumor location was poor, and efforts to identify the optimal local treatment approach for such patients are warranted.