tbuckley/cabot-search huggingface dataset:
Anastomotic Leakage
Journal: BMJ (1974)

Disposal of Unused Medicines More than 300,000 unused tablets, capsules, and other medicines were returned to chemists in the Metropolitan Borough of Stockport during the town's campaign for the disposal of unwanted medicines and pills.The campaign was launched on 16 October by the Metropolitan Borough of Stockport in conjunction with local pharmacists.More than one in 20 of all home accidents dealt with at Stockport Infirmary concern child poisoning, and 400, of these cases are child- ren who have swallowed medicines pre- scribed for other people.
Stomatology In General Practice.
Journal: JAMA (1913)

Few medical men could tell without investigation where the University of Otago is situated. It will not be uninteresting therefore to note that the author of the present work is at the head of the dental school of this university, which is an independent school of the University of New Zealand, located at Dunedin. The work attempts to fill the gap between dentistry and medicine. The author says, with reason, that it should be compulsory for every medical student to attend a short course on dental surgery or stomntology. Such a course is obligatory in the University of Otago, and the present publication is an amplification of lectures delivered to a postgraduate class of medical practitioners and also to medical students. The work includes the anatomy and physiology of the teeth, stomatitis, gingivitis, caries of the teeth, deformities of the jaw and teeth, fractures of the jaw, oral tumors, etc.
Inability of Retroviral Tests to Identify Persons With Chronic Fatigue Syndrome, 1992
Journal: JAMA (1993)

Chronic fatigue syndrome (CFS) is characterized by prolonged, debilitating fatigue. Although the cause of CFS unknown, CDC and researchers in other organizations have been investigating whether infection with a previously unidentified retrovirus might be an etiologic factor. Based on reports suggesting that retroviral infection with a human T-lymphotropic virus type 2 (HTLV-II)-like retrovirus or a spumavirus might be associated with CFS, some research and commercial laboratories developed assays to test specimens from persons with CFS. Even though the hypothesized association between infection with retroviruses and CFS has not been confirmed, these tests are used commonly to evaluate patients with CFS. This report summarizes the findings of a controlled, blinded study conducted in 1992 to determine whether three retroviral tests can distinguish serologically between patients with CFS (i.e., case-patients) and healthy controls.
BOOK REVIEWS
Authors: J. M. KIRKWOOD
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article BOOK REVIEWS Get access Malignant Melanoma: Biology, Diagnosis, and Therapy. L. Nathanson, ed. Dordrecht, The Netherlands: Kluwer Academic Publishers, 1988, 197 pp. $75. JOHN M. KIRKWOOD JOHN M. KIRKWOOD Medical Oncology Division, Department of Medicine, Pittsburgh Cancer Institute, University of PittsburghDeSoto at O'Hara St. Pittsburgh, PA 15213 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 16, 16 August 1989, Page 1259, https://doi.org/10.1093/jnci/81.16.1259 Published: 16 August 1989
Abstracts and Reviews of Current Literature
Journal: Annals of the Rheumatic Diseases (1939)

The author reviews the conclusions of many authoritie3 upon this question and reports the results of experiments he has carried out to elucidate the problem.Aschoff, Graff and Fahr think that articular rheumatism is a specific infection, though the exciting agent has not yet been discovered.In contrast with this view Klinge and Rossle think that the so-called fibrinoid degenera- tion is due to an allergic reaction.Rossle limits his opinion in this respect to acute articular rheumatism, whereas Klinge includes the chronic forms of arthritis, muscular rheumatism, gout and neuralgias.Klinge thinks that bacterial proteins are the allergic factor, but Gudzent considers they probably derive from decomposed foods and from proteins of animal and vegetable origin.These authors attach the term "visceral rheumatism " to many disorders of the heart, the pleura, the joints, arteries and veins.Kammerer regards allergy as partly inborn, partly acquired specific reactivity to certain substances which are harmless to the normal person.Berger regards allergy as an antibody diathesis, using the term " diathesis " as a symptomless state in which the body is ready to react.An allergic disease may thus be regarded as an interaction between allergens and the antibody reaction.Gudzent bases his views on the results of skin tests; in 10 per cent. of non-rheumatic persons positive re- actions occurred, and these he regards as due to a latent rheumatic state.The author has carried out experiments using allergenine, which is prepared from certain protein solutions.Out of 60 cases of acute and chronic arthritis, in 19 only was an unequivocal result obtained, and of these 11 gave negative results.He reports that his experiments have been repeated by others in 230 cases, with similar results.He also tested a series of patients suffering from diseases other than rheumatism, and out of 48 persons 39 gave positive results.He draws the conclusion on 242on July 17,
Abstract 1801: The Benefit of an Early Invasive Strategy in Women Versus Men with Non-ST-Elevation Acute Coronary Syndromes: A Collaborative Meta-Analysis of Randomized Trials
Authors: Michelle O’Donoghue, Marc S Sabatine, William E Boden, Eugene Braunwald, Christopher P Cannon, Tim C Clayton, Robbert J de Winter, Keith A Fox, Bo Lagerqvist, Peter A McCullough, Sabina A Murphy, Rudolf Spacek, Eva Swahn, Lars Wallentin, Fons Windhausen
Journal: Circulation (2007)

Background: Although an early invasive strategy (INV) is frequently used in patients with non-ST-elevation acute coronary syndromes (NSTEACS), some trials have shown this strategy to be associated with worse outcomes in women. We conducted a collaborative meta-analysis of randomized trials of INV vs. conservative strategy (CONS) stratified by gender and biomarker (CK-MB or troponin) elevation. Methods : The principal investigators for each trial provided data on the incidence of death (D), non-fatal MI (MI) and rehospitalization with ACS by gender &amp; biomarker elevation through long-term follow-up. Odds ratios from each trial were combined using a random-effects model with weighting based on inverse variance. Results: Data were combined across 8 trials (3075 women, 7074 men). The OR for D/MI/ACS for INV vs. CONS was 0.83 in women (95% CI 0.68–1.01) and 0.75 in men (95% CI 0.58 – 0.98) with no significant heterogeneity between genders (P=0.54). In women, the benefit of INV tended to be greater in those with elevated biomarkers (OR 0.73, 0.58 – 0.92), compared with those without (OR 0.99, 0.67–1.47) (P interaction=0.19). In contrast, men benefited from INV irrespective of biomarker status (OR 0.78, 0.57–1.07 and OR 0.75, 0.58 – 0.98, P interaction=0.85). For patients in the INV arms, women were more frequently found to have no significant coronary artery disease (stenosis diameter &lt;50%) at angiography than were men (27% vs 8%, P&lt;0.001). Conclusions: In patients with NSTEACS, an INV strategy reduces the composite of death, MI or rehospitalization with ACS to a similar extent in both women and men. Elevated biomarkers of necrosis may help identify women who benefit most from an INV strategy. Death, Non-fatal MI or Rehospitalization with ACS*
Bowel infarction as a cause of death in dialysis patients
Authors: S. M. Diamond
Journal: JAMA (1986)

Bowel infarction as a frequent occurrence in patients with end-stage renal disease has not been previously recognized. This report describes 12 dialysis patients with nonocclusive bowel infarction. All patients with bowel infarction had large weight losses secondary to vomiting, diarrhea, or ultrafiltration when undergoing dialysis, preceding the development of this disease. Of the potential risk factors analyzed, frequent and severe hypotension (systolic blood pressure, &lt;100 mm Hg) when receiving dialysis occurred more commonly in patients developing bowel infarction. The weight loss was not often recognized initially as an important compromising problem. A fatal outcome was experienced in nine of the 12 patients. We conclude that bowel infarction may be a significant cause of morbidity and mortality in dialysis patients. (<i>JAMA</i>1986;256:2545-2547)
Clinical Factors Explain Differences in Frequency of Cardiac Procedures between Men and Women after Cardiac Catheterization
Journal: Annals of Internal Medicine (2002)

Summaries for Patients21 May 2002Clinical Factors Explain Differences in Frequency of Cardiac Procedures between Men and Women after Cardiac CatheterizationSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-10-200205210-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Studies have shown that men get more tests and treatments for heart disease than do women. Possible explanations for these differences are that men may have more severe disease than women or that prejudice may lead doctors to offer more tests and treatments to men than to women. Cardiac catheterization is a test in which doctors inject dye into a patient's circulatory system to look for blockages in heart blood vessels and for poor heart function. Options for treating patients with blocked heart blood vessels include medication or ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Sex Differences in Access to Coronary Revascularization after Cardiac Catheterization: Importance of Detailed Clinical Data.” It is in the 21 May 2002 issue of Annals of Internal Medicine (volume 136, pages 723-732). The authors are WA Ghali, PD Faris, PD Galbraith, CM Norris, MJ Curtis, LD Saunders, V Dzavik, LB Mitchell, and ML Knudtson, for the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians–American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSex Differences in Access to Coronary Revascularization after Cardiac Catheterization: Importance of Detailed Clinical Data William A. Ghali , Peter D. Faris , P. Diane Galbraith , Colleen M. Norris , Michael J. Curtis , L. Duncan Saunders , Vladimir Dzavik , L. Brent Mitchell , Merril L. Knudtson , and Metrics 21 May 2002Volume 136, Issue 10Page: I-40KeywordsBlood vesselsCardiac surgeryCardiovascular therapyCatheterizationCoronary revascularizationGeographic areasHeartHeart diseasesLongitudinal studiesRevascularization ePublished: 21 May 2002 Issue Published: 21 May 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Prepaid entitlements: a new challenge for physician-patient relationships
Authors: J. L. Schroeder
Journal: JAMA (1985)

The transition from a fee-for-service model to a prepaid health care system can sometimes result in stresses for both physicians and patients. Both could feel trapped as patients approach the system with objectives that may be unrealistic, while physicians feel threatened or suspect that patients are abusing the services. Based on their experience in a large multispecialty academic group practice, the authors have developed management strategies to improve the physician patient relationship in prepaid care settings. These include review of marketing efforts, patient education to foster realistic expectations, a policy for dealing with dissatisfied patients and physicians, a strong central administrative physician to resolve differences of opinion, and continuing physician orientation and education to improve judgment and attitudes.
Irritability.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute meprobamate poisoning. A fatal case following a lucid interval
Authors: E. H. Jenis
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Financial Disclosure.
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vascular Disease and Serum Lipids in Diabetes Mellitus. Observations over Thirty Years (1931-1961)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PECULIAR: An open label, multicenter, single-arm, phase 2 study of neoadjuvant pembrolizumab (PEM) and epacadostat (EPA), preceding radical cystectomy (Cy), for patients (pts) with muscle-invasive urothelial bladder cancer (MIUBC).
Authors: Andrea Necchi, Alberto Briganti, Marco Bianchi, Daniele Raggi, Patrizia Giannatempo, Roberta Luciano', Maurizio Colecchia, Nicola Fossati, Giorgio Gandaglia, Renzo Colombo, Andrea Gallina, Andrea Salonia, Roberto Salvioni, Siraj Mahamed Ali, Jeffrey S. Ross, Jon Chung, Francesco Montorsi
Journal: Journal of Clinical Oncology (2018)

TPS4595 Background: MIUBC is a systemic disease and > 40% of pts develop recurrence after Cy. Despite neoadjuvant chemotherapy yields Level 1 evidence, it is underutilized worldwide and a small survival improvement is deemed over Cy alone. PEM is an EMA and FDA-approved therapy for metastatic UC after platinum failure or for cisplatin-ineligible pts. EPA, an anti-IDO1 agent, combined with PEM, safely improved the response-rate in UC in phase 1 trial. Our hypothesis is that PEM+EPA, given neoadjuvantly, could further improve downstaging MIUBC. Methods: Pts with T2-T3b N0 UC with residual disease after transurethral resection of the bladder (TURB, surgical opinion, cystoscopy or radiological presence) will receive 3 cycles of PEM 200mg intravenously, q3 weekly. EPA will be orally taken at the dose of 100 mg BID, from d1 until 10 days before Cy. Cy should be performed within 3 weeks of the last PEM dose. Computed tomography (CT) scan, 18FDG-PET/CT scan, and multiparametric bladder MRI (mpMRI) will be done during screening and before Cy to stage and evaluate response. After Cy, pts will be managed according to EAU guidelines. Adjuvant anti PD-1 therapy is not allowed. PD-L1 status will be assessed using Dako anti-PD-L1 antibody (clone 22C3), relying on the combined positivity score (CPS). Pathologic complete response (pT0) is the primary endpoint. All pts enrolled who receive at least 1 cycle of study drug will be included in the ITT analysis. The H1 is pT0≥25% and H0 pT0≤15%. A MinMax 2-stage design will be used to estimate the number of pts required. Out of 71 total pts, with the first stage of 43 pts, ≥6 pT0 will be required in the first stage, and ≥14 pT0 in the whole study population. Correlative research on blood samples will include immune-cell profiling and cytokine assessment. In tumor samples, genomic analyses will be done with FoundationONE test (Foundation Medicine Inc.). Tumor mutational burden (TMB) will be determined on 1.1 Mbp of sequenced DNA and reported as mutations (mut) per megabase (Mb) and microsatellite instability (MSI) will determined on 114 loci (EudraCT number 2017-002379-24). Clinical trial information: 2017-002379-24.
Medical intensive care for the elderly. A study of current use, costs, and outcomes
Authors: E. W. Campion
Journal: JAMA (1981)

All admissions (2,693) to a medical intensive and coronary care unit (ICU/CCU) during a two-year period were reviewed to compare indications for admission, major interventions, and outcomes for elderly patients with those for younger patients. Once admitted to the ICU/CCU, older patients were more likely to receive major life-support interventions such as mechanical ventilation but less likely to survive. Major interventions were used in 32% of patients aged 75 years or older, in 26% of those 65 to 74 years, and in 22% of those 55 to 64 years. Nonetheless, elderly patients had no longer mean lengths of stay and no greater mean hospital charges. Hospital mortality for the oldest patients was 16%, compared with 14% and 8% for the younger age groups. Cumulative mortality one year after discharge for those older than 75 years was 44%. Elderly hospital survivors returned to their preadmission living situation but did not regain their preadmission activity level. (<i>JAMA</i>1981;246:2052-2056)
Authors' response
Authors: Omid Sadr-Azodi, Nicola Orsini, Alicja Wolk, Åke Andrén-Sandberg
Journal: Gut (2012)

The polarization processes for M1 versus M2 macrophages are quite distinct in the context of changes in cellular metabolism. M1 macrophages are highly glycolytic, whereas M2 macrophages require a more oxidative nutrient metabolism. An important part of M1 polarization involves upregulation of the glucose transporter (GLUT) GLUT1 to facilitate increased glucose uptake and glycolytic metabolism; however, the role of other glucose transporters in this process is largely unknown. In surveying the Functional Annotation of the Mammalian Genome and Gene Expression Omnibus Profiles databases, we discovered that the glucose transporter GLUT6 is highly upregulated in LPS-activated macrophages. In our previous work, we have not detected mouse GLUT6 protein expression in any noncancerous tissue; therefore, in this study, we investigated the expression and significance of GLUT6 in bone marrow–derived macrophages from wild-type and GLUT6 knockout C57BL/6 mice. We show that LPS-induced M1 polarization markedly upregulated GLUT6 protein, whereas naive macrophages and IL-4–induced M2 macrophages do not express GLUT6 protein. However, despite strong upregulation of GLUT6 in M1 macrophages, the absence of GLUT6 did not alter M1 polarization in the context of glucose uptake, glycolytic metabolism, or cytokine production. Collectively, these data show that GLUT6 is dispensable for LPS-induced M1 polarization and function. These findings are important because GLUT6 is an anticancer drug target, and this study suggests that inhibition of GLUT6 may not impart detrimental side effects on macrophage function to interfere with their antitumor properties.