tbuckley/cabot-search huggingface dataset:
PBB Inhibits Metabolic Cooperation in Chinese Hamster Cells in vitro: Its Potential as a Tumor Promoter
Authors: James E. Trosko, B. Dawson, C.C. Chang
Journal: Environmental Health Perspectives (1981)

Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells. Using a nonlethal range of the chemical, PBB was shown to inhibit metabolic cooperation (a form of cell-cell communication) in a manner similar to other known tumor promoters. Results suggest that PBB could act, epigenetically, as a teratogen and a carcinogenic promoter.
Scholarship Erosion
Authors: John G. Sotos
Journal: Annals of Internal Medicine (2006)

Letters4 July 2006Scholarship ErosionJohn G. Sotos, MDJohn G. Sotos, MDFrom Apneos Corporation, Belmont, CA 94002.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-1-200607040-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Has the convenience of Internet searching caused Annals to lower its standards of scholarship? The letter from McAlister and Sener (1) raises this and other questions. In describing a new physical sign, the letter asserted, “In the 19th century, George Henry Fox is reputed to have noted bruising of the groin in hemorrhagic pancreatitis.” A Web site was the reference for this statement.The first question is: Has innuendo become acceptable scholarship in Annals?The second, larger, question is: Why did the editors allow the authors to reference a Web site? A simple PubMed search (“fox[au] AND ...References1. McAlister VC, Sener A. Demarcated truncal jaundice: a sign of retroperitoneal bile leakage [Letter]. Ann Intern Med. 2005;142:389. [PMID: 15738463] LinkGoogle Scholar2. Fox JA. A diagnostic sign of extraperitoneal haemorrhage. Br J Surg. 1966;53:193-5. [PMID: 5907449] CrossrefMedlineGoogle Scholar3. Sotos JG. Cullen's and Turner's signs [Letter]. N Engl J Med. 2006;354:979-80; author reply 979-80. [PMID: 16514713] Google Scholar Author, Article, and Disclosure InformationAffiliations: From Apneos Corporation, Belmont, CA 94002.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDemarcated Truncal Jaundice: A Sign of Retroperitoneal Bile Leakage Vivian C. McAlister and Alp Sener Scholarship Erosion Robert G. Badgett , Michael Berkwits , and Cynthia Mulrow Metrics 4 July 2006Volume 145, Issue 1Page: 77KeywordsConflicts of interestDNAInternetMutationPancreatitis ePublished: 4 July 2006 Issue Published: 4 July 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
THE PROTEIN INTAKE OF PRESCHOOL CHILDREN
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Splenic rupture due to infectious mononucleosis. Normal selective arteriogram and peritoneal lavage
Authors: M. K. Aung
Journal: JAMA (1978)

INFECTIOUS mononucleosis generally is regarded as a benign disease with an estimated mortality of less than 0.1%.<sup>1</sup>Splenic rupture is a common cause of mortality<sup>2</sup>and usually occurs in the second or third week of the illness when the spleen may be maximally enlarged and there is weakness of the capsule, trabeculae, and vascular wall.<sup>1</sup>Rupture can occur spontaneously or with minimal trauma. The most common symptom is abdominal pain. Abdominal tenderness frequently is associated with signs of peritoneal irritation and often is accompanied by anemia. Findings from peritoneal lavage can be expected to be abnormal in a high percentage of cases. Reportedly, a selective splenic arteriogram is highly reliable in the detection of rupture. Our report demonstrates that many of the clinical and roentgenographic studies employed in diagnosing splenic rupture can be misleading. <h3>Report of a Case</h3> A 23-year-old man was hospitalized because of severe left
TMOD-14. ESTABLISHMENT AND MOLECULAR CHARACTERIZATION OF PATIENT DERIVED CELL LINES FROM LOW GRADE GLIOMA
Authors: Ashraf Zaman, Robert Rapkins, Sheri Nixdorf, Charlie Teo, Kerrie McDonald
Journal: Neuro-Oncology (2016)

Low Grade Gliomas (LGGs), although they are rare in incidence, usually affect younger adults (20-40 years of age) with patient survival varying between 5-15 years. The in vitro culturing of LGG and subsequent mutational profiling would be an invaluable tool for: (1) understanding mechanisms underpinning progression; (2) identifying novel diagnostic, prognostic and predictive biomarkers; and (3) identifying new treatment strategies using drug screening. Our aim is to develop and characterize patient derived LGG in vitro models through phenotypic, genetic and epigenetic analyses. Fresh LGG specimens were collected from the Prince of Wales Private Hospital, Sydney. All tumor samples were dissociated and cultured in serum free media supplemented with EGF and FGF. The minimum time to expand the cells from one passage to the next was at least 3 weeks. Successful cell lines were harvested at different passages. Molecular characterization of the tissue and cell lines were conducted using Sanger sequencing, Western blot, immunocytochemistry, short tandem repeat analyses and methylation arrays. 15 IDH1 mutant LGG cell lines were developed from 34 freshly collected specimens. IDH1 mutation exclusively reverted back to wild type in all cell lines within several passages. Further molecular characterization of LGG associated genes (for example p53, ATRX, TERT) and epigenetic studies through methylation arrays of paired tumor tissue samples and cell lines enabled us to better determine the selective pressures associated with in vitro culturing of patient derived glioma cell lines. We have established and characterized LGG cell lines derived from patient tumor material and provided a unique resource to better understand LGG biology and improve targeted treatment strategies whilst also detailing the extent to which in vitro models of patient derived glioma cell lines mimic their tumor of origin.
Interaction of Asbestos with Alveolar Cells
Authors: Yasunosuke Suzuki
Journal: Environmental Health Perspectives (1974)

A number of electron microphotographs are presented showing the various aspects of phagocytosis of fibers in lung tissue. The fibers were rapidly phagocytosed by alveolar macrophages, by polymorphonuclear leucocytes, and less frequently by alveolar epithelial cells. They were also found in the cytoplasm of the alveolar stromal macrophages. In the late stage of the disease, macrophages containing the minerals were recognized in the fibrous submesothelial connective tissues. In this stage, a cell intermediate in structure between the epithelial cell and the macrophage was observed in the alveolar lining. This cell showed strong phagocytic activity against the fibers. The process of phagocytosis of the fibers was quite similar to that of other microparticles such as Thorotrast and India ink. It had been suggested that phagosomes containing the fibers became transformed into secondary lysosomes. The fate of the phagocytosed fibers varied. Some were partly dissolved or digested with marked reduction in the thickness of the wall of the chrysotile fibril. Many became coated by hemosiderin which accumulated in the cytoplasm of the phagocytic cells. This coating transformed the fibers into asbestos bodies. Finally many fibers were released because of the death of the host cell. Uncoated fibers as well as various stages of phagocytosis were observed in all animals, including those 1 to 2 years after the instillation of asbestos. This strongly suggests that fibers may be repeatedly phagocytosed, released and rephagocytosed, inducing a continuous response of the alveolar cells and maintaining the disease.
TRAFFIC ACCIDENTS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stridor
Authors: M. Addy
Journal: BMJ (1981)

<h3>Objective</h3> To identify novel proteins involved in the pathogenesis of rheumatoid arthritis (RA) and to characterise the identified proteins based on pathogenic and therapeutic aspects. <h3>Methods</h3> The authors applied differential phosphoproteomic analysis to articular synoviocytes between RA and osteoarthritis (OA) to identify proteins differently phosphorylated between RA and OA. Focusing on annexin VII (Anx7), one of the highly phosphorylated proteins in RA, the authors prepared <i>Anx7</i>-transgenic C57BL/6 (<i>Anx7</i>-Tg-B6) mice to evaluate their susceptibility to collagen-induced arthritis (CIA). In addition, the authors examined the effect of anti-Anx7 antibodies (Abs) on CIA and serum levels of cytokines in wild-type DBA/1J mice, which are known to be susceptible to CIA, and in <i>Anx7</i>-Tg-B6 mice. In vitro, the authors examined the effect of the Anx7 knockdown by small interfering RNA on the secretion of cytokines in rheumatoid synoviocytes and the human synovial sarcoma cell line SW982. <h3>Results</h3> The <i>Anx7</i> transgene altered the CIA-resistant B6 mice to CIA-susceptible ones. The Abs treatment suppressed CIA even in the wild-type DBA/1J mice. The serum levels of cytokines including interleukin 6 (IL-6) and TNFα were not altered by the Abs treatment in vivo. On the other hand, the knockdown of Anx7 by small interfering RNA caused downregulation of IL-8 secretion in vitro. <h3>Conclusions</h3> These results indicate that Anx7 participates in the pathogenesis of RA partly through the secretion of IL-8. The study data have demonstrated the pathogenic roles and therapeutic significance of Anx7 in RA for the first time.
Sideroblastic Anemia
Authors: Paul I. Liu
Journal: JAMA (1987)

An 81-year-old man was admitted for workup of anemia. His red blood cell (RBC) count was 2.6×10<sup>6</sup>/mm<sup>3</sup>(2.6 × 10<sup>12</sup>/L); hemoglobin level, 7.3 g/dL (73 g/L); hematocrit reading, 22.1% (0.22); mean corpuscular volume, 72 μm<sup>3</sup>; and mean corpuscular hemoglobin level, 24 pg. The peripheral blood smear showed a dimorphic picture, ie, normocytic cells admixed with a preponderantly microcytic-hypochromic RBC population and rare siderocytes. Prussian blue stain of the bone marrow disclosed numerous ringed sideroblasts,<sup>1,2</sup>which are erythroblasts with coarse iron granules arranged around the nucleus (Figure). The diagnosis was acquired sideroblastic anemia secondary to isoniazid use. Sideroblastic anemia is a hematologic disorder that occurs under a variety of circumstances. Rarely is it hereditary, being more commonly an acquired condition. Acquired sideroblastic anemia can be secondary to exposure to certain drugs and toxins. Implicated are antituberculous drugs (with isoniazid the most common offender), antibiotics
NERVE DEAFNESS DUE TO CONGENITAL SYPHILIS IN THREE CHILDREN
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intrauterine systems with levonorgestrel may decrease hysterectomy rate
Journal: BMJ (1998)

Violations of code of marketing breast milk substitutes are commonThe international code of marketing of substitutes for breast milk was adopted by the World Health Assembly in 1981 to encourage mothers to breast feed and to ensure that women make informed choices when deciding how to feed their babies.On p 1117 Taylor reports the results of a study investigating violations of the code in four countries.Despite their stated support for the code, manufacturers of breast milk substitutes continue to provide free samples of substitutes, bottles, and teats to health professionals.Health facilities play an important part in distributing these samples to pregnant women and mothers of infants.There is an urgent need for implementation and monitoring of the code nationally; the study protocol used to investigate these issues could be applied easily to other countries.
Voluntary Motherhood: A Discussion of the Various Contraceptive Methods, with Emphasis on Generally Approved Techniques
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The intensity of CEACAM-1 expression in melanoma patients and the timing of treatment with recombinant human interferon & 2b showed correlation with survival
Authors: C. L. Mihalcioiu, P. Watson, S. Alowami
Journal: Journal of Clinical Oncology (2004)

7561 Background: In this retrospective analysis, we tested if the timing of interferon (iFN) as adjuvant or as treatment of the relapse, when correlated with CEACAM-1 intensity, affects survival. Methods: After ethics approval was obtained, paraffin blocks from 27 patients previously diagnosed with malignant melanoma were analyzed using immunohistochemical staining with monoclonal CEACAM-1 antibody. The patients were grouped based on intensity; weakly positive (intensity 0–1) and strongly positive (intensity 2–3). Each group was analyzed based on survival status, pathological stage, and the time iFN was started. Results: Grade 3 intensity was identified in 10 patients, 6 of whom died (60%) and 4 patients are alive (2 relapsed but are disease-free). None of these patients had T4 or N1–2 disease at presentation. Adjuvant low-dose iFN was given in 4/10 patients, and 3/4 patients (75%) were alive at 3–5 years follow-up. High-dose iFN was given at the time of relapse in 6/10 patients and 5/6 patients died (83%) from disease progression. Grade 2 intensity was identified in 7 patients and 4 of them died (57%) and 3 patients are alive (2 relapsed but are disease-free). Adjuvant iFN was given in 4/7 patients and 3/4 remained alive (75%). iFN was started at the time of the first relapse in 3/7 patients; all 3/3 died (100%). Grade 1 intensity was observed in 10 patients and 3/10 died (30%). Out of 7 patients alive, 5 relapsed, but remained disease-free after local treatment at 4–7 years follow-up. Adjuvant iFN was given in 6/10 patients with 50% success rate (3/6 died). In 4/10 patients, iFN was given at first relapse and 4/4 (100%) are alive and disease-free at 4–7 years follow-up. Conclusions: Grade 2 and 3 intensity for CEACAM-1 correlates with poor prognosis despite early stage at diagnosis, but adjuvant iFN seems to correlate with survival benefit. Grade 1 intensity patients have a high survival rate and the timing of iFN was associated with good survival in both settings. No significant financial relationships to disclose.
LUNG CANCER AS AN OCCUPATIONAL DISEASE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cephalexin nephrotoxicity. Reversible nonoliguric acute renal failure and hepatotoxicity associated with cephalexin therapy
Authors: C. G. Fung-Herrera
Journal: JAMA (1974)

OF THE cephalosporin group of antibiotics, cephaloridine has been demonstrated to be a nephrotoxic agent, and clinical evidence is accumulating to indicate cephalothin sodium as a cause of acute renal failure in some instances. An elderly mildly diabetic patient was treated for a urinary tract infection with normal dosage of cephalexin monohydrate. The patient developed transient nephrohepatotoxicity but this condition responded to withdrawal of the drug. <h3>Report of a Case</h3> A 70-year-old white man was admitted to the hospital on May 27, 1973, complaining of dysuria, chills, and fever of seven days' duration. No hematuria was found. Two days later he was treated with sulfonamides and ampicillin. He was a known diabetic receiving tolbutamide medication. Fifteen years ago, he underwent a radical prostatectomy for carcinoma. He had passed uric acid stones on four previous occasions, the last on March 28, 1973. Urine sample disclosed a specific gravity of 1.015 and
PREMATURE OLD AGE. HOW TO AVOID IT.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Unit of Measure
Authors: Sam Halabi, O Neill
Journal: JAMA (2017)

Marcus Lind, MD, PhD; William Polonsky, PhD; Irl B. Hirsch, MD; Tim Heise, MD; Jan Bolinder, MD, PhD; Sofia Dahlqvist; Erik Schwarz, MD, PhD; Arndís Finna Ólafsdóttir, RN; Anders Frid, MD, PhD; Hans Wedel, PhD; Elsa Ahlén, MD; Thomas Nyström, MD, PhD; Jarl Hellman, MD
THE PRESENT STATUS OF SPINAL SURGERY.
Authors: SAMUEL LLOYD
Journal: JAMA (1901)

<h3>TUMORS.</h3> This field of surgical activity only dates back to 1887. Gowers and Horsley were the first to undertake any operation for intravertebral tumor, but since then many other surgeons have had satisfactory results. It is true that tumors involving the spine had been operated on earlier, but they were favorable cases where there was an extravertebral manifestation. Of the 58 reported by Gowers and Horsley, all the patients died except the one operated on by Mr. Horsley, yet 80 per cent. of these could have been completely relieved by operation, and those which were hopeless might have been benefited if the pressure had been removed. The careful studies made by Starr, Mills and Gowers and many other observers have enabled the surgeon to do brilliant work in this class of cases. There can be no question of what one would do in a case of extravertebral tumor producing pressure