tbuckley/cabot-search huggingface dataset:
Anesthol.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Invitations to the Opening Exercises of the New Admission and Isolation Building at the North Reading State Sanatorium and the Children's Building at the Lakeville State Sanatorium
Journal: New England Journal of Medicine (1930)

Correspondence from The New England Journal of Medicine — Invitations to the Opening Exercises of the New Admission and Isolation Building at the North Reading State Sanatorium and the Children's Building at the Lakeville State Sanatorium
CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
Authors: Sandrine Henri, Lionel Franz Poulin, Samira Tamoutounour, Laurence Ardouin, Martin Guilliams, Béatrice de Bovis, Elisabeth Devilard, Christophe Viret, Hiroaki Azukizawa, Adrien Kissenpfennig, Bernard Malissen
Journal: The Journal of Experimental Medicine (2010)
Pregnancy following closed mitral valvuloplasty. A long-term study with remarks concerning the necessity for careful cardiac management
Authors: W. A. Wallace
Journal: JAMA (1971)

One hundred and thirty-nine women who underwent closed mitral valvuloplasty and subsequently became pregnant have been followed up for 1 to 17 years (mean, 10 years) following surgery. The overall postoperative course of these women was not altered by childbearing, when compared with the courses of the other patients in the series of which they are a part, and when a subgroup of 113 of the 139 women was compared with a matched control group. A review of five deaths which occurred in relation to pregnancy revealed that in at least three cardiac management was inadequate. Physicians as well as patients often wrongly consider surgery for valvular disease curative and do not apply the usual careful treatment that all patients with cardiac disease should receive.
Asthma management in five European countries: doctors' knowledge, attitudes and prescribing behaviour
Authors: P. Lagerløv, C.C.M. Veninga, M. Muskova, E. Hummers-Pradier, C. Stålsby Lundborg, M. Andrew, F.M. Haaijer-Ruskamp
Journal: European Respiratory Journal (2000)

The aim of the study was to examine the relationship between guideline recommendations on asthma management, and the performance of doctors in five different European health care contexts. Knowledge, attitudes and prescribing behaviour of doctors recruited to an educational project was investigated. A total of 698 general practitioners from Germany, The Netherlands, Norway and Sweden, and 94 specialists from the Slovak Republic participated. A questionnaire was used to assess their knowledge and attitudes. Antiasthmatic drugs dispensed to their patients reflected their prescribing behaviour. In response to questions on how to treat chronic asthma, most doctors were in agreement with guideline recommendations. In practice, however, the proportion of asthma patients receiving inhaled steroids varied almost twofold, ranging 31% in Germany to 58% in The Netherlands. On questions related to exacerbation of asthma, German and Slovakian doctors often preferred treatment with antibiotics to steroids. They also more often associated yellow-green sputum with bacterial infection. In conclusion, although many doctors in different health care contexts have accepted the recommendations given in guidelines, the proportion of their patients treated accordingly differed. German and Slovakian doctors seem to attach less importance to the inflammatory features of asthma than the doctors from the other three European countries.
Commentary
Journal: JAMA (1971)

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Hypothyroidism with Graves' disease
Authors: E. D. Michaelson
Journal: JAMA (1970)

A 27-year-old woman had rapidly progressive ophthalmopathy and pretibial myxedema. The protein-bound iodine concentration was 2.5μg/100 ml. The 24-hour radioactive iodine uptake was 0.6% and did not increase after stimulation with thyrotrophin. Results of a serum assay for the long-acting thyroid stimulator (LATS) were positive with a response index of 273%. The antithyroglobulin titer was 1:512 and a thyroid biopsy showed thyroiditis. The findings in this case emphasize that Graves' disease is a systemic illness in which the typical manifestations may occur without hyperthyroidism and this can be explained by a lack of sufficient functional thyroid tissue to respond to those factors which would ordinarily produce thyrotoxicosis. In hypothyroidism, where the uptake of radioactive iodine is insufficent to demonstrate nonsuppressibility, positive finding of a LATS assay suggests Graves' disease.
Hepatobiliary disposition of valproic acid and valproate glucuronide: Use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions
Authors: C Booth
Journal: Hepatology (1996)

Previous work in this laboratory has suggested that the nonlinear disposition of valproic acid (VPA) in the rat may be due to nonlinear distribution of VPA into the liver. The present study was undertaken to elucidate further the hepatobiliary disposition of VPA. VPA (0.1-2 mmol/L) was incubated with isolated rat hepatocytes in vitro. Uptake of [3H]-VPA was linear from 10 to 50 seconds, with minimal (<7 percent) biotransformation. The initial velocity of VPA uptake varied in proportion with the extracellular concentration and was temperature independent, suggesting that VPA traverses the hepatocyte membrane predominantly by passive diffusion. In separate studies, the hepatobiliary disposition of VPA (20mg) was examined in the isolated perfused rat liver (IPL). A pharmacokinetic model was developed to describe the influence of phenobarbital on the hepatobiliary disposition of VPA and valproate glucuronide (V-G) in the IPL; all processes governing VPA and V-G disposition appeared to be linear. Acute administration of phenobarbital to the liver (1.12 mg) decreased the rate constant for canalicular egress of V-G (0.0489 +/- 0.0266 vs. 0.164 +/- 0.075 min−1). In vivo pretreatment with phenobarbital (75 mg/kg/d x 5 d) before liver isolation decreased the biliary excretion of both VPA (1.06E-04 +/- 0.27E-04 vs. 2.76E-04 +/- 0.45E-04 min−1) and V-G (5.63E- 03 +/- 1.98E-03 vs. 1.74E-02 +/- 0.5E-02 min−1), and increased the apparent volume of distribution of VPA (84.6 +/- 2.2 vs. 72.3 +/- 2.1 mL). In vivo phenobarbital pretreatment a changed V-G excretion from a formation to an elimination rate-limited process. These results are consistent with phenobarbital-associated impairment of canalicular egress of some organic anions. This work further supports the utility of pharmacokinetic modeling in: (1) determining the rate-limiting steps in hepatobiliary drug disposition and (2) identifying sites of drug interactions within the hepatobiliary system that may not be evident based on conventional mass-balance analysis.
Censura et Cavilla
Authors: George X. Trimble
Journal: JAMA (1964)

<h3>To the Editor:—</h3> To the astute Dr. Conlon I extend my gratitude and admiration for not hesitating to be identified as a reader of Critique and Cavil. Dr. Conlon, understandably, objects to the words, "<i>Mene Mene Tekel Upharsin</i>," being lumped with the Latin phrases preceding them, and so, by implication, appearing to be of Latin origin. Dr. Conlon is, of course, correct in pointing out that they are not. I must confess that I, too, was aware of this, but succumbed to a glosso-buccal urge—and a lumping instinct—hoping that a splitter would stand up and be counted among those who manifested the lifted-eyebrow syndrome on seeing the "<i>Mene</i>...." quotation in sequence with the Latin ones. Dr. Conlon will note the ammunition I had in reserve in "<i>Cris de Coeur</i>" just in case "<i>Mene</i>, etc" missed the mark as a gambit. Dr. Conlon obviously is very well informed on the
Towards Mental Health: The Schizophrenic Problem.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal Vidarabine Toxicity in a Patient With Normal Renal Function
Authors: Linda Van Etta
Journal: JAMA (1981)

PATIENTS experiencing disseminated varicella-zoster infection may have significant morbidity in the form of pain, extreme fevers (temperature ≥40 °C), rigors, anorexia, malaise, and, rarely, pneumonia, hepatitis, and encephalitis.<sup>1</sup>Initially, vidarabine sodium phosphate showed promising results in disseminated herpes zoster with a very low incidence of clinical toxicity.<sup>2</sup>More recently, however, several authors have reported cases of possible neurological toxicity. This toxicity was manifested by tremors, dysarthria, confusion, coma, or a combination.<sup>3-5</sup>Death occurred in several patients.<sup>6</sup>Except for one patient with evidence of renal insufficiency, symptoms developed during administration of the drug. We have recently observed a patient with disseminated varicella-zoster infection in whom severe, ultimately fatal, CNS symptoms developed 48 hours after completion of an initial three-day course of vidarabine. We report the details of this case of apparent vidarabine CNS toxicity that occurred in the presence of normal renal function in a patient with
Clinical Summaries
Journal: Circulation (2008)

Among Patients With Coronary Artery Bypass GraftsDepression and depressive symptoms are highly prevalent among patients with coronary artery disease and independently predict adverse cardiovascular events.Several mechanisms have been proposed to explain this association, including decreased adherence to treatment and increased prevalence of unfavorable lifestyle characteristics, among others; however, few studies have investigated the potential link between depressive symptoms and progression of atherosclerosis.Accordingly, we evaluated the hypothesis that depressive symptoms are associated with progression of atherosclerosis among individuals with previous coronary artery bypass graft surgery and saphenous vein grafts enrolled in the Post-CABG Trial.Depressive symptoms over the previous week were assessed at trial enrollment, and quantitative coronary angiography was conducted at enrollment and 4 to 5 years later.We found that the presence of depressive symptoms was associated with a higher risk of substantial progression of saphenous vein graft atherosclerosis and a decrease in minimum lumen diameter and that this association was virtually eliminated by random assignment to aggressive lipid lowering with high-dose lovastatin.Our analysis provides prospective evidence for a direct association between depressive symptoms and atherosclerotic progression as a potential mechanism for the corresponding association of depressive symptoms with clinical prognosis.See p 2313.
Inhibition of viral replication by mutants of the duck hepatitis B virus core protein Department of Medicine, University Hospital Freiburg, Germany
Journal: Hepatology (1995)

The risk of liver cancer is greatest in people both infected with hepatitis B virus (HBV) and highly exposed to aflatoxin B1 (AFB1). The tree shrew (Tupaia belangeri chinensis) is a unique species that can be infected with human HBV, is susceptible to AFB1-induced liver cancer, and shows a synergistic interaction between HBV and AFB1 for liver cancer. In this regard, the tree shrew may be useful for evaluating experimental chemoprevention strategies relevant to high-risk human populations as it mirrors the human epidemiology of liver cancer. To begin developing the model for chemoprevention study, two groups of tree shrews were fed 400 μg AFB1/kg b.wt. in milk daily for 4 weeks. One week prior to AFB1 administration, one group also received oltipraz (0.5 mmol/kg, p.o.) daily for 5 weeks. At weekly intervals, 1 ml of blood and a 24-h urine sample were obtained from each animal. Aflatoxin-albumin adducts in serum were determined by a radioimmunological assay and aflatoxin-N7-guanine adducts in urine were measured by HPLC. Aflatoxin-albumin adducts increased rapidly in 2 weeks to plateau at 20 pmol/mg protein, and they diminished after cessation of AFB1 exposure. Oltipraz significantly attenuated the overall burden of aflatoxin–albumin adducts throughout the exposure period with a median reduction of 80%. In a single cross-sectional analysis at the end of AFB1 dosing, oltipraz treatment decreased urinary aflatoxin-N7-guanine by 93%. Collectively, these results indicate that oltipraz reduces AFB1 risk biomarkers in the tree shrew in a manner similar to that observed in rodents and humans, and establishes a rationale to evaluate cancer chemoprevention by oltipraz in human HBV-infected, AFB1 exposed tree shrews.
Die Radikaloperation des Ohres ohne Gehörgansplastik bei chronischer Mittelohreiterung, die Aufmeisselung und Nachbehandlung bei akuter Mastoiditis, nebst einer Darstellung der Entwicklung der Schädeloperation bei akuter und chronischer Mittelohreiturung.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Table Footnote
Journal: JAMA (1964)

complaint that he had severe frontal and occipital head¬ aches which had started three days after taking the medica¬ tion.His blood pressure was 150/90 mm Hg lying and 130/90 mm Hg standing.Dosage of methyldopa was re¬ duced to 250 mg three times daily.Three days later he telephoned and again complained of severe headaches.Methyldopa was discontinued, and the patient resumed his previous medication.About six weeks later, he stated that he had had no more headaches since discontinuing methyl¬ dopa.His sitting blood pressure was 160/90 mm Hg.He was seen again in about a month, and the headaches had not returned.Case 27.-A female, aged 57 years, had essential hyper¬ tension for eight years.Her blood pressure at the first visit was 170/120 mm Hg lying and 160/120 mm Hg standing.Methyldopa therapy was initiated, 250 mg four times daily.Results of liver-function tests and other laboratory tests
Changes in lipid and lipoprotein levels after weight training
Authors: L. Goldberg
Journal: JAMA (1984)

Lipid and lipoprotein levels were prospectively studied in previously sedentary men (mean age, 33 years) and women (mean age, 27 years) undergoing 16 weeks of weight-training exercise. Women demonstrated a 9.5% reduction of cholesterol, 17.9% decrease in low-density lipoprotein (LDL) cholesterol and 28.3% lowering of triglycerides. The ratios of total cholesterol-high-density lipoprotein (HDL) cholesterol and LDL cholesterol-HDL cholesterol were reduced 14.3% and 20.3%, respectively. Among men, LDL cholesterol was reduced 16.2%, while the ratios of total cholesterol-HDL cholesterol and LDL cholesterol-HDL cholesterol were lowered 21.6% and 28.9%, respectively. Weight-training exercise appears to result in favorable changes in lipid and lipoprotein levels in previously sedentary men and women. (<i>JAMA</i>1984;252:504-506)
Myxedema in hyperthyroidism
Authors: F. A. Kingery
Journal: JAMA (1965)

Myxedema, strictly speaking, is a boggy swelling of the skin and subcutaneous tissue which results from the deposition of mucin. It traditionally occurs in hypothyroid states, and recognition of this generalized nonpitting edema provides the physician with a reason to suspect hypothyroidism. The lesions of<i>localized myxedema</i>which usually occur in the pretibial areas are also collections of mucin in the skin, as the name implies. These circumscribed lesions develop<i>not</i>in the hypothyroid patient as one might expect, but rather in the hyperthyroid individual who almost invariably has exophthalmos. The lesions usually appear after medical or surgical suppression of thyroid activity. Mucin in either type of myxedema appears to be the same. It represents an increase of the mucin normally present in the ground substance of the dermal connective tissue, and it can be demonstrated histochemically with a stain for acid mucopolysaccharides, such as Alcian blue, methylene blue, or
Error in Subject Area
Journal: JAMA Network Open (2020)

Leigh G. Goetschius, MS; Tyler C. Hein, MD; Sara S. McLanahan, PhD; Jeanne Brooks-Gunn, PhD; Vonnie C. McLoyd, PhD; Hailey L. Dotterer, MS; Nestor Lopez-Duran, PhD; Colter Mitchell, PhD; Luke W. Hyde, PhD; Christopher S. Monk, PhD; Adriene M. Beltz, PhD
THE PARATHYROID GLANDS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Establishment and Expression Profiling of New Lung Cancer Cell Lines from Chinese Smokers and Lifetime Never-Smokers
Authors: David C. L. Lam, Luc Girard, Wai-Sing Suen, Lap-ping Chung, Vicky P. C. Tin, Wah-kit Lam, John D. Minna, Maria P. Wong
Journal: Journal of Thoracic Oncology (2006)
MISCELLANY.
Journal: JAMA (1998)

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