tbuckley/cabot-search huggingface dataset:
Ciliary Disorientation in Patients with Chronic Upper Respiratory Tract Inflammation
Authors: Charlotte F. J. Rayner, Andrew Rutman, Ann Dewar, Peter J. Cole, Robert Wilson
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Random ciliary orientation was recently described as a possible variant of primary ciliary dyskinesia (PCD). The cilia have normal ultrastructure and nearly normal ciliary beat frequency (CBF) but lack efficacy because the beat direction is disoriented. However, delayed mucociliary clearance (MCC), transitory changes in ultrastructure, and slowed CBF can all occur in the presence of inflammation. This study investigated groups of patients with upper respiratory tract inflammation caused by infection to assess whether ciliary disorientation was present and its relation to MCC. The study population consisted of 10 healthy nonatopic nonsmoking volunteers, 15 patients with idiopathic bronchiectasis and chronic mucopurulent sinusitis, 12 patients with cystic fibrosis, and two patients with the clinical features of PCD but normal CBF and ciliary ultrastructure. Ciliary disorientation was significantly (p < 0.05) increased in the three patient groups compared with the volunteers, being greatest in the two patients with the clinical features of PCD and in bronchiectasis patients with P. aeruginosa, and was positively correlated (r = 0.9) with MCC but not with CBF. Treatment of one patient with antibiotics and topical corticosteroids for a prolonged period resulted in ciliary disorientation returning to normal. Ciliary disorientation may therefore occur secondary to inflammation caused by infection, and the study suggests that ciliary disorientation rather than ultrastructural abnormalities or slow CBF results in delayed MCC.
Quality of health and health care
Authors: K. I. Shine
Journal: JAMA (1995)

The demise of federal efforts at health care system reform produced a number of losers. The non—Medicaid-eligible poor will continue to struggle for adequate access to appropriate health care, particularly preventive and primary care services. Academic health centers will be adversely affected by the unwillingness of managed care organizations to pay a significant portion of the research and education costs previously financed from patient care revenues. Many Americans will potentially be at risk because of the failure to create any national mechanism for adequate oversight and assessment of quality of care. Although many managed care organizations initially were established to improve the quality of care for their members and all of these organizations espouse a commitment to quality, the reality remains that a cost-driven system runs the risk of compromising quality, particularly for those least able to understand it or to assess it. With the return of the focus of
托法替布在慢性斑块型银屑病中的获益风险特征
Authors: B.E. Strober, A.B. Gottlieb, P.C.M. Kerkhof, L. Puig, H. Bachelez, E. Chouela, S. Imafuku, D. Thaçi, H. Tan, H. Valdez, P. Gupta, M. Kaur, V. Frajzyngier, R. Wolk
Journal: British Journal of Dermatology (2019)

尽管重度银屑病有一些高效治疗,但其中很多必须通过注射给药,且它们在一些患者中无效。托法替布是一种新型口服(经口服用的)药物,可抑制一种名为 Janus 激酶的酶。它已被证实对名为类风湿关节炎和溃疡性结肠炎的疾病有益,并已在银屑病中对其使用进行了研究。来自欧洲、北美和南美以及日本的作者们审评了 6 项评估托法替布治疗中或重度斑块型银屑病患者的获益和风险的临床试验。收集的数据包括超过 5,000 患者-年龄。患者每天两次接受 5mg 或 10mg 治疗,并在 4 个月后和 1 年后接受评估。此药物总体耐受良好,副作用与当前可用于中至重度银屑病的“生物治疗”相似,但带状疱疹(蛇盘疮)感染的发生率略高,尤其在使用较高剂量时。剂量越高越有效,总体而言,患者的生活质量显著改善,皮肤和指甲的外观改善,瘙痒症状迅速减轻。作者们得出结论,此药有效,且安全性特征可接受。由于只有一项比较其与一种生物治疗(依那西普)疗效的公开试验,因此亟需与现有药物进行进一步比较。但是,较之注射给药,很多患者更愿意使用口服药物;注射反应是生物治疗的一个重要问题。
Effect of infectious hepatitis on the immunoglobulins in mentally retarded children
Authors: G. A. LoGrippo
Journal: JAMA (1966)

In this study, the humoral immunologic status of 60 institutionalized children with infectious hepatitis was evaluated during the acute or icteric stage and followed one, four, and seven months after the sudden onset of the disease. The determination of the humoral immunologic status consisted of the following: (1) the study of serum protein distribution by acetate electrophoresis mobility; (2) quantitative evaluation of serum by immunochemical analysis for immunoglobulins (Ig),<sup>1</sup>IgA (7S<sub>γ1</sub>, βA), IgM (19S<sub>γ1</sub>, βM), and IgG (7S<sub>γ2</sub>); and (3) qualitative evaluation of serum IgG for virus neutralizing antibody response on 8 to 12 standard enteric viruses as well as viruses isolated from patients during the acute stage of hepatitis. These data are correlated for the 60 patients who had either clinical jaundice or an increase in serum glutamic pyruvic transaminase (SGPT) levels, or both. It was not surprising to find varying increases in immunoglobulin levels
In vivo diagnostic testing and immunotherapy for allergy. Report I, Part II, of the Allergy Panel. Council on Scientific Affairs
Journal: JAMA (1987)

The first article in this series discussed the importance of properly designed clinical trials to validate various diagnostic and therapeutic procedures and also described clinically accepted and proved tests. This article discusses other challenge tests and unproved procedures. The value of provocation-neutralization procedures has been controversial; two promising clinical models have been developed that may allow definitive trials of efficacy. Immunotherapy with allergenic extracts has been shown to be a safe and effective procedure in carefully selected patients treated with potent, well-standardized antigens administered in adequate dosage. It has been proposed that many nonspecific signs or symptoms could be caused by exposure to Candida albicans or low-dose environmental substances. The cause-and-effect relationships between exposure to C albicans or other environmental substances and the disorders that are alleged to be associated with them are, for the most part, unproved.
Surgically Correctable Acquired Cystic Disease of the Lung as Seen in Flying Personnel
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
My Life Transformed.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Minimal residual disease quantification by flow cytometry provides reliable risk stratification in T-cell acute lymphoblastic leukemia
Authors: S. Modvig, H. O. Madsen, S. M. Siitonen, S. Rosthøj, A. Tierens, V. Juvonen, L. T. N. Osnes, H. Vålerhaugen, M. Hultdin, I. Thörn, R. Matuzeviciene, M. Stoskus, M. Marincevic, L. Fogelstrand, A. Lilleorg, N. Toft, O. G. Jónsson, K. Pruunsild, G. Vaitkeviciene, K. Vettenranta, B. Lund, J. Abrahamsson, K. Schmiegelow, H. V. Marquart
Journal: Leukemia (2019)
INDUSTRIAL SUPPORT OF NUTRITIONAL RESEARCH
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experiences With Obtaining Influenza Vaccination Among Persons in Priority Groups During a Vaccine Shortage—United States, October-November, 2004
Journal: JAMA (2005)

After the announcement that the supply of inactivated influenza vaccine available to the U.S. public for the 2004-05 influenza season would be reduced by approximately one half, the Advisory Committee on Immunization Practices (ACIP) recommended that the remaining vaccine supply should be reserved for 1) certain groups of persons at high risk for serious health problems from influenza, 2) health-care workers involved in direct patient care, and 3) close contacts of children aged <6 months. To determine what proportion of persons at increased risk for influenza complications had been vaccinated as of the day of the survey, what proportion sought vaccination but did not receive it because of the shortage, and what factors might be dissuading persons at high risk from seeking influenza vaccination, Harvard School of Public Health (HSPH), in collaboration with International Communications Research, conducted a national survey. This report summarizes the results of that survey, which indicated that approximately 63% of persons aged > or =65 years and 46% of chronically ill adults who tried to get the influenza vaccine were able to do so. More than half of adults at high risk did not try to get the influenza vaccine. Because available supplies of inactivated influenza vaccine are targeted to high-risk groups, persons in these groups should continue to pursue vaccination.
The Geographical Distribution of the Malaria Carrying Mosquitoes.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COLPOPERINEORRHAPHY AND THE STRUCTURES INVOLVED.
Authors: BYRON ROBINSON
Journal: JAMA (1898)

The second step of the operation is to introduce the sutures of silkworm gut. The two fingers are removed from the rectum and well cleaned. The point of the handled needle is introduced at the upper angle of the wound (No. 2 in Fig. 21) without penetrating the skin or vaginal mucous membrane, carried along about one-half inch from the distal edge of the vaginal flap and made to emerge at the median raphe. It is then threaded and drawn out. The point of the needle is again introduced at the upper angle of the wound on the opposite side (No. 4 in Fig. 21), forced along the distal edge of the flap about one-half inch from the edge and made to emerge again on the median line. It is threaded and drawn out. This constitutes the first suture. Generally three anterior sutures are introduced in the above manner. To
Coffee intake and serum lipids in men
Authors: Karl F. Weyrauch
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In view of the possible effect of coffee creamer on plasma lipoprotein concentrations, I was surprised to find no attempt to quantify creamer intake in the population studied by Williams et al.<sup>1</sup> Perhaps comparison of the data for the drinkers of black coffee and for those using milk, half and half, or nondairy creamer would help clarify this relationship.
Ambulatory Blood Pressure Monitoring
Authors: Tamar S. Polonsky, George L. Bakris
Journal: JAMA (2018)

A 65-year-old woman with prior RCA NSTEMI treated with PCI presents with home BP fluctuations from <120/80 mm Hg to 200/100 mm Hg and mean 24-hour ambulatory measures of <160/90 mm Hg. How do you interpret the results?
PELLAGRA
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract A01: Metastasis suppressors regulate the tumor microenvironment by blocking recruitment of pro-metastatic tumor-associated macrophages
Authors: Daniel C. Rabe, Casey Frankenberger, Russell Bainer, Devipriya Sankarasharma, Kiran Chada, Thomas Krausz, Yoav Gilad, Lev Becker, Marsha Rich Rosner
Journal: Cancer Research (2016)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR02) of the Conference Proceedings. Citation Format: Daniel C. Rabe, Casey Frankenberger, Russell Bainer, Devipriya Sankarasharma, Kiran Chada, Thomas Krausz, Yoav Gilad, Lev Becker, Marsha Rich Rosner. Metastasis suppressors regulate the tumor microenvironment by blocking recruitment of pro-metastatic tumor-associated macrophages. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr A01.
Medicolegal
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathology of the Nervous System
Authors: Martin R. Krigman
Journal: JAMA (1969)

The first of a two-volume set, this text fulfills the need for a neuropathology source book in English. The editors have obtained for this volume contributions from 79 authors, most of whom are recognized authorities who have made significant contributions in their special fields. The first volume is organized into 14 sections, each varying from three to ten chapters in length. The first volume is unique in that it is neither a textbook for the student nor merely a compendium of pathology; rather, neuropathology is presented as an aspect of neurobiological science. A considerable portion of the volume is devoted to related topics in anatomy, physiology, and biochemistry and to special techniques. Of the 14 sections, the first seven include the introduction, consideration of basic architecture, special microscopy, special areas of investigation, basic chemical methods, basic physiological mechanisms, and pathophysiology of fluids. Although the treatment of many of these topics
Lidocaine and Sinus Standstill
Authors: T. O. Cheng
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Judgment
Authors: Theresa E Vettese
Journal: Annals of Internal Medicine (2012)

On Being a Doctor21 August 2012JudgmentTheresa E. Vettese, MDTheresa E. Vettese, MDFrom Wayne State University School of Medicine, Detroit, MI 48201.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-4-201208210-00015 Audio Reading - “Judgment” Audio. Listen to a reading of "Judgment" by Theresa E. Vettese, MD. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail His reddish hair was long and matted, dreadlocks by default, a few tobacco-stained teeth peeked out from behind his shaggy beard. The man had very few lines around his eyes, and I was startled to realize that he was so young.His ankles were shackled to the bed rails, his wrists bound with leather. Yet, he had one weapon left and he aimed with precision, spitting gobs of sputum toward the guards and us.In this hospital, we care for the uninsured, the worn out, the worn down, the abusers of themselves and others. Those without money to pay the ... Author, Article, and Disclosure InformationAffiliations: From Wayne State University School of Medicine, Detroit, MI 48201.Corresponding Author: Theresa E. Vettese, MD, Wayne State University School of Medicine, 4201 St. Antoine, Suite 2E, Detroit, MI 48201; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Judgment” Audio. Listen to a reading of "Judgment" by Theresa E. Vettese, MD. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 21 August 2012Volume 157, Issue 4Page: 296-297KeywordsAdverse reactionsBipolar disorderDecision makingResearch laboratoriesResidencyRespirationSchizophreniaSleepSputumToxicity ePublished: 21 August 2012 Issue Published: 21 August 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...