tbuckley/cabot-search huggingface dataset:
Cerebrospinal fluid penicillin levels during therapy for latent syphilis
Authors: J. Ducas
Journal: JAMA (1981)

Cerebrospinal fluid and serum penicillin levels were determined in patients with latent syphilis. Mean serum concentration one week after the third weekly dose of 2.4 million units penicillin G benzathine was 0.32 units/mL. Concurrent administration of probenecid orally produced a mean serum penicillin level of 0.41 units/mL. Doubled penicillin doses without and with daily orally administered probenecid resulted in mean serum concentrations of 0.75 and 1.00 units/mL, respectively. Two of six patients in the last group had CSF penicillin concentrations greater than 0.03 units/mL. (<i>JAMA</i>1981;246:2583-2584)
Experimental Models for Study of Common Respiratory Viruses
Authors: Wallace A. Clyde
Journal: Environmental Health Perspectives (1980)

Numerous epidemiological studies have shown that there is excess respiratory disease morbidity in areas of high atmospheric pollution, implying an interactive effect on the clinical illness associated with these common infections. The principal etiologic agents of human respiratory infections are respiratory syncytial virus (RSV), influenza viruses (IV), parainfluenza virus types 1 and 3 (P1, P3), adenoviruses (AD), rhinoviruses (RV) and Mycoplasma pneumoniae (Mpn). Understanding the pathogenesis of the excess morbidity related to pollutants would facilitate detection of undesirable human health effects and provide a basis for intervention strategies. Through use of experimental model systems the mechanism of toxic effects could be defined (whether microbiological, immunological, pathological or physiological) to provide direction for appropriate studies in the human host. Small animal models of IV and Mpn infections have been available for many years; recently, experimental models of several more common viral diseases have been developed. A parallel to human RSV infections is provided by the ferret: virus replicates in the lungs of infant animals, but only in the noses of adults. The common cotton rat infected with RSV develops small airways lesions which may mimic the pathophysiologic changes of bronchiolitis. Both guinea pigs and Syrian hamsters are susceptible to human P3 virus, developing peribronchiolar and interstitial lesions. Practical small animal models for human AD and RV infections are not available because of the high host-specificity of these agents. Both the RSV and P3 model infections are nonlethal which enables study for long-term sequelae. Recent reports of pulmonary function abnormalities among children suffering bronchiolitis in infancy underscores the importance of defining toxic influences which could play a role by making the initial infections more severe.
Fitz-Hugh-Curtis syndrome. A laparoscopic approach
Authors: J. A. Reichert
Journal: JAMA (1976)

Four of our patients had classical Fitz-Hugh-Curtis syndrome. Persistent right upper-quadrant pain prompted extensive medical evaluation; antibiotic therapy failed to relieve the symptoms. In each case, laparoscopy proved to be an ideal method for obtaining definitive diagnosis and therapy. Typical perihepatic violin-string adhesions were cauterized and divided under direct vision, with dramatic resolution of symptoms. (<i>JAMA</i>236:266-268, 1976)
TRADE PAMPHLETS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Academic Couples
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Facial Paralysis in Acute Poliomyelitis.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PaperChase. Self-service bibliographic retrieval
Authors: G. L. Horowitz
Journal: JAMA (1983)

During the past three years, from terminals within Beth Israel Hospital, Boston, 3,654 persons used a computer program called PaperChase to search the medical literature. While performing 39,022 searches, these persons had 1,976,421 references displayed and selected 449,690 of them for printing. Throughout this period, the program underwent continual modification. Each year the number of searches increased--from 10,678 to 11,541 to 16,803. Each year the percentage of new users who were unsuccessful decreased--from 16 to 13 to 11. By the end of the third year, 549 people had completed 20 or more searches. PaperChase enables people to search the medical literature themselves, and thus provides a new experience in computerized bibliographic retrieval. When made available without charge in a teaching hospital, PaperChase is widely used.
Incidence Of and Risk Factors For Acute Myeloid Leukemia Involvement Of The Central Nervous System
Authors: Rozovski Uri, Maro Ohanian, Farhad Ravandi, Guillermo Garcia-Manero, Stefan H. Faderl, Jorge E. Cortes, Sherry R. Pierce, Kantarjian Hagop, Zeev Estrov
Journal: Blood (2013)
Managing hypertension in pregnancy
Authors: C. Marwick
Journal: JAMA (1990)

OBSTETRICIANS and internists have resolved a long-standing disagreement about managing the hypertensive pregnant patient. Traditionally, obstetricians have been cautious about taking steps to reduce blood pressures in pregnancy for fear of compromising the circulation to the fetus, except in certain circumstances. On the other hand, "we internists have tended to throw up our hands whenever obstetricians say 'don't treat'," says Ray Gifford, MD, Cleveland Clinic Foundation. Gifford chaired a nine-member working group, sponsored by the National Heart, Lung, and Blood Institute, to resolve these differences. The report has the approval of
Medical News.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, April–May 1971
Journal: JNCI Journal of the National Cancer Institute (1971)

Journal Article Manuscripts Approved for JNCI, April–May 1971 Get access JNCI: Journal of the National Cancer Institute, Volume 46, Issue 6, June 1971, Pages 1363–1365, https://doi.org/10.1093/jnci/46.6.1363-b Published: 01 June 1971
THE MEDICAL ASPECTS OF THE MODERN "SKY SCRAPER."
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Terlipressin therapy with and without albumin for patients with hepatorenal syndrome: Results of a prospective, nonrandomized study
Authors: R Ortega
Journal: Hepatology (2002)

Vasopressin analogues associated with albumin improve renal function in hepatorenal syndrome (HRS). The current study was aimed at assessing the efficacy of the treatment, predictive factors of response, recurrence of HRS, and survival after therapy. Twenty-one consecutive patients with HRS (16 with type 1 HRS, 5 with type 2 HRS) received terlipressin (0.5-2 mg/4 hours intravenously) until complete response was achieved (serum creatinine level < 1.5 mg/dL) or for 15 days; 13 patients received intravenous albumin together with terlipressin. Twelve of the 21 patients (57%) showed complete response. Albumin administration was the only predictive factor of complete response (77% in patients receiving terlipressin and albumin vs. 25% in those receiving terlipressin alone, P = .03). Treatment with terlipressin and albumin was associated with a remarkable decrease in serum creatinine level, increase in arterial pressure, and suppression of the renin-aldosterone system. By contrast, no significant changes in these parameters were found in patients treated with terlipressin alone. Only 1 patient showed ischemic adverse effects. Recurrence of HRS occurred in 17% of patients with complete response. The occurrence of complete response was associated with an improved survival. In conclusion, terlipressin therapy reverses HRS in a high proportion of patients. Recurrence rate after treatment withdrawal is uncommon. Albumin appears to improve markedly the beneficial effects of terlipressin. (HEPATOLOGY 2002;36:941-948.)
VITAL STATISTICS OF ONTARIO.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wage-earning school children
Journal: BMJ (2003)

oesophageal biopsy, because the data are from routine clinical practice, our findings may have more relevance for standard care than previous studies.We thank Colin Fox, Richard Middleton, Tom Wylie, and the tumour verification officers of the Northern Ireland Cancer Registry for help processing pathology records; the administrative, medical, and pathology staff of local healthcare trusts; the staff of the Directorate of Information Services for help compiling the Northern Ireland Barrett's register; and Deirdre Fitzpatrick and Chris Patterson for statistical advice.
Hyperphagia
Authors: Edward M. Stricker
Journal: New England Journal of Medicine (1978)

THERE is a substantial minority of people whose body weights are considerably in excess both of average values and, more important, of values that are appropriate for good health. Interest in them, and in the basic processes underlying maintenance of body weight and the control of food intake, has promoted the development of many animal models for hyperphagia. These models differ greatly from one another. In some of them obesity does not accompany overeating because energy losses increase as well, owing to lactation, thermogenesis or work. In other models, however, hyperphagia is associated with considerable increases in body weight. This . . .
<b>:</b><b>Number</b>*<b>of Youths Aged 2–19 Years and Adults Aged ≥20 Years with Obesity</b>†<b>or Severe Obesity</b>§<b>— National Health and Nutrition Examination Survey, 2015–2016</b>
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Youths AdultsNo. of persons (millions) * 95% confidence intervals indicated with error bars.The number of adults and youths with obesity and severe obesity was calculated by multiplying the unadjusted (crude) prevalence by the average population totals for 2015-2016 (74.3 million youths and 234.5 million adults).Prevalence estimates exclude pregnant females.† Body mass index (BMI) is calculated as weight in kilograms divided by height in meters squared.Obesity among youths was defined as sex-specific BMI-for-age at or above the 95th percentile of the CDC growth charts, and obesity among adults was defined as BMI ≥30.§ Severe obesity among youths was defined as sex-specific BMI-for-age at or above 120% of the 95th percentile of the CDC growth charts, and severe obesity among adults was defined as BMI ≥40.During 2015-2016, in the United States, there were 13.7 million youths (18.5%) with obesity, including 4.2 million youths (5.6%) with severe obesity.During this same period, in the United States, there were 93.3 million adults (39.8%) with obesity, including 17.8 million adults (7.6%) with severe obesity.
Long-term efficacy of interferon alpha-2b and lamivudine in combination compared to lamivudine monoteraphy in patients with chronic hepatitis B. A multicenter, randomized trial
Authors: G. Barbaro, F. Zechini, A.M. Pellicelli, R. Francavilla, G. Scotto, D. Bacca, M. Bruno, S. Babudieri, M. Annese, F. Matarazzo, G. Di Stefano, G. Starnini, C. Zocchetti, G. Barbarini
Journal: Journal of Hepatology (2001)
Adjuvant pamidronate (PMT) therapy for the prevention of bone metastasis in breast cancer (BC) patients (pts) with four or more positive nodes
Authors: I. Kokufu, N. Kohno, S. Takao, M. Yamamoto, M. Miyashita, S. Kohno, F. Kimura
Journal: Journal of Clinical Oncology (2004)

530 Background: In BC pts, bone is the most frequent site of distant metastasis. The pathogenesis of bone metastasis is thought that BC cells produce osteoclast activating factors which induce osteoclast resorption of bone, leading to the development of lytic bone disease. Bisphosphonates (BPs) demonstrate highly effective inhibition of osteoclast bone resorption and have beneficial effects on bone metastases. Because of their mechanism, BPs are expected to prevent the development of bone metastases. PMT is a potent inhibitor of osteoclast activity. We examined whether adjuvant PMT therapy could prevent or delay the development of bone metastases in BC pts at high risk for bone metastases. Methods: Between 1997 and 2001, 90 pts with primary BC and four or more positive nodes were assigned by patients preference to receive PMT therapy (PMT 45mg iv every 2 weeks times 4 cycle; n=33) or control (C) (no therapy; n=57). All pts underwent surgical treatment and the type of adjuvant systemic therapy was based on the protocols of each center. The clinicopathological characteristics of the pts (age, tumor size, nodal status, menopausal status, hormonal status, type of chemotherapy ) were well balanced. The median follow-up period was 5.4 years. Results: Bone metastases were detected in 4 pts (12.1%) in the PMT group and in 22 pts (38.6%) in the C group (p=.008). Distant metastases (36.4% vs 52.6%, p=.136) and visceral and soft tissue metastases (30.3% vs 45.6%, p=.153) were detected lower in the PMT group compared with the C group, but no statistically significant. Six pts (18.2%) in the PMT group and 15 pts (26.3%) in the C group died (p=0.379). Overall survival and disease-free survival rates were equal in the both groups. Bone metastasis free survival was significantly higher in the PMT group compared to the C group (85.0% vs 63.8% at 5 years, p=.035). Conclusion: In the PMT group, the incidence of bone metastases was significantly reduced and bone metastasis free survival was significantly higher. We conclude that adjuvant PMT therapy significantly reduced the development of bone metastases in BC pts with four or more positive nodes. No significant financial relationships to disclose.
Abstract 2217: Serum metabolic profiling identified a distinct metabolic signature in bladder cancer smokers: A key metabolic enzymes associated with patient survival
Authors: Chandra S. Amara, Chandrashekar R. Ambati, Venkatrao Vantaku, Piyarathna W b Danthasinghe, Sri Ramya Donepudi, Shiva S. Ravi, James M. Arnold, Vasantha Putluri, Gurkamal Chatta, Khurshid A. Guru, Hoda Badr, Martha K. Terris, Roni Bollag, Arun Sreekumar, Andrea B. Apolo, Nagireddy Putluri
Journal: Cancer Research (2019)

Abstract Urinary bladder cancer (BLCA) is the 9th most common malignant disease and the 13th most common cause of cancer death worldwide. Occupational exposure to carcinogens has been long associated with increased BLCA risk. Tobacco smoke contains more than 60 carcinogens causing at least 18 different types of cancer including BLCA. Reliable biomarkers for accurately predicting survival in Bladdder cancer (BLCA) smokers is lacking due to complex genomic and transcriptomic heterogeneities associated with the disease. We performed liquid chromatography-mass spectrometry (LC-MS) based targeted metabolomic analysis for &amp;gt;300 metabolites in serum obtained from two independent cohorts of BLCA never smokers, smokers, healthy smokers, and healthy never smokers. 40 metabolites (FDR &amp;lt;0.25) were identified to be differential between BLCA never smokers and smokers. Increased abundance of amino acids (tyrosine, phenylalanine, proline, serine, valine, isoleucine, glycine, asparagine) and taurine levels were observed in BLCA smokers. Integration of differential metabolomic gene signature and transcriptomics from TCGA cohort resulted in intersecting 17 gene signature that showed significant correlation with patient survival in BLCA smokers. Importantly Catechol-O-Methyltransferase (COMT), Iodotyrosine Deiodinase (IYD), and Tubulin Tyrosine Ligase (TTL) showed a significant association with patient survival in publicly available BLCA smokers datasets and did not have any clinical association in never smokers. Note: This abstract was not presented at the meeting. Citation Format: Chandra S. Amara, Chandrashekar R. Ambati, Venkatrao Vantaku, Piyarathna W b Danthasinghe, Sri Ramya Donepudi, Shiva S. Ravi, James M. Arnold, Vasantha Putluri, Gurkamal Chatta, Khurshid A. Guru, Hoda Badr, Martha K. Terris, Roni Bollag, Arun Sreekumar, Andrea B. Apolo, Nagireddy Putluri. Serum metabolic profiling identified a distinct metabolic signature in bladder cancer smokers: A key metabolic enzymes associated with patient survival [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2217.