tbuckley/cabot-search huggingface dataset:
THE SEASON OF THE STUDENT.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I study of preoperative capecitabine and lenvatinib with external radiation therapy in locally advanced rectal adenocarcinoma.
Authors: Jessica Frakes, Rutika Mehta, Sarah E. Hoffe, Iman Imanirad, Maria E Martinez Jimenez, Julian Sanchez, Mokenge Peter Malafa, Seth Felder, Sophie Dessureault, Richard D. Kim
Journal: Journal of Clinical Oncology (2019)

694 Background: Despite routine use of neoadjuvant chemoradiation, patients with advanced rectal tumors experience significant rates of treatment failure and recurrence. Radiation resistance is a particular problem. Dual targeting of PDGF and VEGFR (Vascular endothelial cell growth factor receptor) in combination with radiation can enhance tumor response. Lenvatinib inhibits the kinase activities of VEGFR1-3, FGFR1-4, PDGFRα, KIT, and RET and in vivo results show that it effectively delays the growth of human colorectal xenografts. Methods: This is a phase I clinical trial of lenvatinib in combination with capecitabine administered with radiation. Patients with stage II or III rectal cancer confirmed by endoscopic ultrasound or MRI were eligible for the study. In this 3+3 phase I study with 3 cohorts, patients were treated with escalating doses of lenvatinib administered in combination with standard doses of capecitabine (850 mg/m 2 PO BID D1-5 weekly for 5 ½ to 6 weeks) and external beam radiation therapy (180 cGY on D1-5 weekly for 5 ½ to 6 weeks). Patients underwent surgery 6-10 weeks after neoadjuvant therapy. Results: Nine patients have been enrolled in the 3 cohorts with the median age of 51 years. Lenvatinib dosing started at 14 mg PO daily (cohort 1) and was safely escalated to 20 mg PO daily (cohort 2) followed by 24 mg PO daily (cohort 3). There were no DLTs at the maximum tested dose of lenvantinib (24 mg). 5 patients have undergone low anterior resection and 4 have had abdominoperineal resection. The pathological complete response (pCR) rate was 33.33%, and downstaging was observed in 100% of patients. Median neoadjuvant rectal cancer score (NAR) was 8.7. Three pts had grade 3 events (2 hypertension (HTN), 1 lymphopenia) without any grade 4 events. Most common AEs were HTN and fatigue. No perioperative complications were observed. Tissues for all pts have been collected for planned correlative studies. Conclusions: This study shows that the combination of lenvatinib with capecitabine, and EBRT is well tolerated. NAR score and downstaging rates are encouraging. Currently we are enrolling 10 additional pts at the maximum tested dose of lenvatinib to further evaluate efficacy and safety. Clinical trial information: NCT02935309.
A Study of the Spatial Vectorcardiogram in Subjects with Anterior Myocardial Infarction
Authors: G. E. BURCH, LEO HORAN, J. A. CRONVICH
Journal: Circulation (1956)

In 20 subjects with anterior myocardial infarction the early portions of the QRS sÊ-loop were directed away from the area of infarction. Deformities that occurred in later portions of the QRS sÊ-loop were compatible with loss of electric force produced by depolarization of areas activated late in the phase of depolarization. This observation is of significance because electrocardiograms, as conventionally recorded and interpreted, fail to detect infarcts located in areas of the heart that are depolarized late and that would not be expected to deform the early portions of the QRS complex sÊ-loop.
An "experimental" epidemic of Reiter's syndrome
Authors: H. R. Noer
Journal: JAMA (1966)

Nine cases of Reiter's syndrome followed 602 cases of proven bacillary dysentery, while none of an equally large group escaping dysentery developed Reiter's disease. All patients were observed from the ingestion of Shigella until their initial return to duty. Venereal disease was excluded as a causative factor. Antibiotics, antihistaminics, and steroids proved ineffective. We have concluded that Reiter's disease may occur as a sequella of bacillary dysentery, with a definite time relationship between the two disorders, that severe conjunctivitis appears to herald severe or recurrent arthritis, and that arthritis seems worst in joints previously weakened by other disease. If initial disability lasts over three months, permanent or recurrent disability is likely, and recurrence is presaged by a rise in the erythrocyte sedimentation rate.
Reply:
Authors: Anna S. F. Lok, Brian J. McMahon
Journal: Hepatology (2007)

We agree with Dr. Jhaveri and Dr. Murray that available data show that there is no evidence of hepatitis B transmission from infected mothers to infants who are breast-fed and that breast-feeding should not be prohibited, particularly for infants who receive appropriate prophylaxis with hepatitis B immune globulin and hepatitis B vaccine. Because of space constraints, it was not possible for the guidelines to include all aspects of hepatitis B management. We appreciate Dr. Jhaveri and Dr. Murray for bringing this to our readers' attention. Anna S. F. Lok*, Brian J. McMahon , * Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI, Liver Disease and Hepatitis Program, Alaska Native Medical Center and Arctic Investigations Program, Centers for Disease Control, Anchorage, AK.
Abstract 5058: Dietary Intake of Fruits and Vegetables Improves Vascular Function in a Dose Dependent Manner - A Randomised Controlled Trial
Authors: Damian O McCall, Claire P McGartland, David McCance, Ian S Young, Jayne V Woodside
Journal: Circulation (2008)

Observational evidence has consistently linked increased fruit and vegetable consumption with reduced cardiovascular morbidity. However, there is little direct trial evidence to support the concept that fruit and vegetable consumption improves vascular function. This study has assessed the dose-dependent effects of a fruit and vegetable intervention on arterial health in subjects with hypertension. Following a common 4 week run-in period during which fruit and vegetable intake was limited to 1 portion/day, participants consumed either 1, 3 or 6 portions daily for the next 8 weeks. Endothelium-dependent and independent arterial vasodilator responses were assessed using venous occlusion plethysmography in the brachial circulation pre- and post-intervention. Compliance was monitored using serial contemporaneous 4-day food records and by measuring concentrations of circulating dietary biomarkers. A total of 118 volunteers completed the 12 week study. Participants in the 1, 3 and 6 portions/day groups reported consuming on average 1.1, 3.2 and 5.6 portions of fruit and vegetables respectively, while serum concentrations of ascorbic acid, lutein and β-cryptoxanthin increased across the groups in a dose-dependent manner. For each 1 portion increase in reported fruit and vegetable consumption, there was a 6.2% improvement in forearm blood flow responses to intra-arterial administration of the endothelium-dependent vasodilator acetylcholine (p=0.03). There was no association between increased fruit and vegetable consumption and vasodilator responses to sodium nitroprusside, an endothelium-independent vasodilator. This study illustrates that among hypertensive volunteers, increased fruit and vegetable consumption produces significant improvements in an established marker of endothelial function and cardiovascular prognosis.
Poster Session 4: Hepatitis C: New Agents (Not Approved)
Journal: Hepatology (2014)

analysis in patients switched to TDF or added TDF, the cumulative probability of CVR was 93.1% at 6 months of therapy.Conclusion: TDF therapy is effective for achieving CVR in ETV PVR patients.We should consider TDF therapy in patients with PVR, if patient have NUC-experience or HBV DNA is above 177 IU/ml at the time of PVR.
A Tumor-Associated Organ-Specific Antigen Characteristic of Spontaneously Metastatic .Rat Mammary Carcinomas&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1975)

An organ-specific tumor-associated antigen (TAA) was present in several metastatic and nonmetastatic mammary carcinomas induced in WF female rats by 3-methylcholanthrene. The level of TAA was high in 2 metastatic carcinomas tested (TMT-081 and SMT-2A) and much lower-by a factor of 50-200-In 2 nonmetastatic mammary carcinomas (MT-100 and MT-W9B). The TAA in the 2 metastatic tumors was identical, as demonstrated by immunodiffusion and supported by cross-reactivity with antibody against TAA from TMT-081 in a binding inhibition radio-immunoassay. The TAA was shed in relatively large amounts by the metastatic tumors maintained in short-term organ culture. The high level and shedding of TAA thus appeared to be characteristics of the metastatic tumors but not of the nonmetastatic ones. This suggests that TAA on the cell membrane or in the circulation may be involved in the metastatic process as a factor blocking potentially cytotoxic cells or in other ways leading to suppression of the immune response against the tumor.
PMO-250 Quantitative proteomics in ulcerative colitis reveals mucosal inflammation reduces levels of keratins in the insoluble fraction of the intermediate filament proteome
Authors: D Majumdar, C Evans, B M Corfe, A J Lobo
Journal: Gut (2012)

<h3>Introduction</h3> Keratins (K) are a key component of intermediate filaments (IF), primarily composed of K8, 18 and 19 in the intestinal epithelia. Apart from a structural role, they may play a role in moderating TNF effects, including cytotoxicity. K8-null mice develop colitis, a subset of patients with IBD have missense mutation in K8 gene. Colonic expression of K8/K18 has been shown to be regulated by IL-6. In order to examine the relationship between acute inflammation and alteration in levels of insoluble IFs in mucosa of patients with ulcerative colitis (UC), we undertook a quantitative proteomic approach using an iTRAQ (isobaric tagging for relative and absolute quantification)-based proteomic workflow. <h3>Methods</h3> Endoscopic biopsies were obtained from patients with UC, from actively inflamed rectum and from non-inflamed proximal colonic mucosa in the same patient (n=10), and from normal controls (n=10). Endoscopic (Baron) and histological assessment was made. An iTRAQ-compatible extraction protocol for insoluble IF proteins was developed. Labelled peptides from pooled patients were analysed by SCX-LC-MS/MS (strong cation exchange-reverse phase HPLC tandem mass spectrometry) and data reconstituted in GeneBio Phenyx. Inter-group comparisons were made using in-house algorithms based on t-testing with multiple test correction. <h3>Results</h3> Median age was 36 years (range 23–71). Endoscopic Baron score was ≥2 in inflamed mucosa for all patients. Tandem mass spectrometry (MS/MS) identified 52 proteins, 32 (61.5%) matched by two or more peptides, showing significant log fold change, with reduced levels of keratins and vimentin in inflamed mucosa compared to controls (Abstract PMO-250 table 1). Abstract PMO-250 figure 1 shows significantly reduced IF protein levels in inflamed mucosa compared to inactive mucosa. Cytokine proteins neutrophil defensin 1 and bone morphogenetic protein 4 were increased only in actively inflamed mucosa. <h3>Conclusion</h3> Using a quantitative proteomic approach, we have shown significantly decreased levels of keratins in the actively inflamed colonic mucosa in UC providing further evidence of interaction between keratins and inflammatory pathways—which requires further elucidation. <h3>Competing interests</h3> None declared.
Insight
Authors: Mary E. Moore
Journal: Annals of Internal Medicine (1996)

On Being a Patient15 March 1996InsightMary E. Moore, PhD, MDMary E. Moore, PhD, MDAlbert Einstein Medical Center, Philadelphia, PA 19141Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-6-199603150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The problems with my eyes had become alarming. Two and a half years ago I was told I had a posterior vitreous detachment in my left eye that had left me with an eye full of floating debris. Over the past 2 weeks, I had developed a similar problem in my right eye, its onset heralded by flashes of light when I turned my head. I found it almost impossible to focus a microscope on joint-fluid samples, a major inconvenience for a rheumatologist. After a MEDLINE search taught me that retinal damage was possible, I decided to consult a specialist ... Author, Article, and Disclosure InformationAffiliations: Albert Einstein Medical Center, Philadelphia, PA 19141Corresponding Author: Mary E. Moore, PhD, MD, Division of Rheumatology, Albert Einstein Medical Center, 103 Korman Building, 5501 Old York Road, Philadelphia, PA 19141. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1996Volume 124, Issue 6Page: 609-610KeywordsAnxietyBladderChartsEmotionsHand strengthOphthalmologyRetinaRunningTechniciansVision Issue Published: 15 March 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Primary biliary cirrhosis: Relation between hepatic function and pulmonary function in patients who never smoked
Authors: M Krowka
Journal: Hepatology (1991)

We studied the relationship between selected variables of hepatic and pulmonary function in 47 patients with primary biliary cirrhosis, who were participating in a prospective study to assess sequential pulmonary function at yearly intervals. An additional 20 patients with primary biliary cirrhosis, who were liver transplant candidates awaiting transplantation, were studied. None of the 67 patients ever smoked cigarettes. Severity of primary biliary cirrhosis was characterized by histological stage and the Mayo risk score derived from a Cox regression model that used the following variables: serum bilirubin and serum albumin levels, age, prothrombin time and clinical severity of edema. Pulmonary function assessment included key variables describing expiratory airflow (forced expiratory volume in 1 sec divided by forced vital capacity) and efficiency of gas exchange (steadystate diffusing capacity for carbon monoxide). We found a significant relationship between histological stage of primary biliary cirrhosis and steady-state diffusing capacity (p = 0.02) and between the Mayo risk score for disease severity and steady-state diffusing capacity (p = 0.03). Progressive deterioration of steady-state diffusing capacity was associated with increasing severity of primary biliary cirrhosis. No relationship existed between pulmonary function and the presence of sicca complex or Sjögren's syndrome or the clinical manifestations of portal hypertension (e.g., esophageal varices, ascites and splenomegaly). No significant relationship existed between expiratory airflow and severity of primary biliary cirrhosis. We conclude that in patients with primary biliary cirrhosis who have never smoked, a statistically significant relationship exists between the severity of the liver disease and the efficiency of gas exchange measured by steady-state diffusing capacity. This association is not related to clinical manifestations of portal hypertension, sicca complex or Sjögren's syndrome. (HEPATOLOGY 1991;13:1095–1100.)
TOC
Authors: Michael Lever, Peter George, Warwick Dellow, Russell Scott, Stephen Chambers, Ashraf Soliman, Ibrahim Nasr, Alaa Thabet, Mustafa Rizk, Wael El Matary, Steven Smith, Lilian De Jonge, Julia Volaufova, Yinmei Li, Hui Xie, George Bray, Jose Mostaza, Nuria Camino, Juan Gerique, Rocío Peña, Margarita Baquero, Carlos Lahoz, Ashok Batta, Guorong Xu, Jaya Bollineni, Sarah Shefer, Gerald Salen, Eun Oh, Eun-Jung Rhee, Ki Oh, Young Lee, Ki Baek, Kun Yoon, Il Kang, Eun Yun, Young Park, Moon Choi, Joon Yoo, Sung Park, Makiko Inaba, Yasushi Otani, Kazuo Nishimura, Natsuki Takaha, Akihiko Okuyama, Masafumi Koga, Junichi Azuma, Ichiro Kawase, Soji Kasayama
Journal: Metabolism (2004)
Was the Schoolmaster Abroad?
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal of Bacteriology, Baltimore
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amiodarone Prophylaxis
Authors: Johan D. Aasbo, Richard G. Trohman
Journal: Annals of Internal Medicine (2006)

Letters21 February 2006Amiodarone ProphylaxisJohan D. Aasbo, DO and Richard G. Trohman, MDJohan D. Aasbo, DOFrom Medical College of Wisconsin, Milwaukee, WI 53226, and Rush University Medical Center, Chicago, IL 60612.Search for more papers by this author and Richard G. Trohman, MDFrom Medical College of Wisconsin, Milwaukee, WI 53226, and Rush University Medical Center, Chicago, IL 60612.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-4-200602210-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Mr. Craycraft's observation that similar cohort data were presented in the studies by Giri and associates (1) and by White and associates (2), both of which were included in our meta-analysis. The number of stroke end points (16 in Giri, 9 in White), the percentage of patients who received β-blockers (72.4% in Giri vs. 89.1% in White), and the percentage of patients who had valvular surgery (26.9% in Giri vs. 18.2% in White) are different in the 2 papers. Although the Annals of Thoracic Surgery identified the publication by White and colleagues as an “Original ...References1. Giri S, White CM, Dunn AB, Felton K, Freeman-Bosco L, Reddy P, et al. Oral amiodarone for prevention of atrial fibrillation after open heart surgery, the Atrial Fibrillation Suppression Trial (AFIST): a randomised placebo-controlled trial. Lancet. 2001;357:830-6. [PMID: 11265951] CrossrefMedlineGoogle Scholar2. White CM, Giri S, Tsikouris JP, Dunn A, Felton K, Reddy P, et al. A comparison of two individual amiodarone regimens to placebo in open heart surgery patients. Ann Thorac Surg. 2002;74:69-74. [PMID: 12118806] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Johan D. Aasbo, DO; Richard G. Trohman, MDAffiliations: From Medical College of Wisconsin, Milwaukee, WI 53226, and Rush University Medical Center, Chicago, IL 60612.Disclosures: Consultancies: R.G. Trohman (Guidant CRM Business Strategy Advisory Board); Honoraria: R.G. Trohman (St. Jude Medical, Inc., Guidant CRM); Grants received: R.G. Trohman (St. Jude Medical, Inc., Medtronic, Inc., Guidant CRM, Wyeth-Ayerst). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAmiodarone Prophylaxis Reduces Major Cardiovascular Morbidity and Length of Stay after Cardiac Surgery: A Meta-Analysis Johan D. Aasbo , Andrew T. Lawrence , Kousik Krishnan , Michael H. Kim , and Richard G. Trohman Amiodarone Prophylaxis Michael E. Craycraft Metrics 21 February 2006Volume 144, Issue 4Page: 303KeywordsAtrial fibrillationDrugsMorbidityProphylaxisStrokeSurgeryThoracic surgery ePublished: 21 February 2006 Issue Published: 21 February 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE OMENTUM
Authors: Arthur E. Hertzler
Journal: JAMA (1926)

<h3>To the Editor:</h3> —I note with interest your current comment on the omentum (The Journal, April 24). I wish to suggest that it never has been proved that peristalsis or change in position of the body will cause the omentum to move. In fact, it has been proved that it does not. When an area becomes inflamed, the omentum becomes hyperemic followed by exudation and leukocytic extravasation. Then and not until then does the omentum move. When the omentum begins to move, peristalsis has already ceased because of the inflammatory reaction within the gut walls. (Compare "Causes of the Migration of the Omentum,"The Journal, April 26, 1913, p. 1292).