tbuckley/cabot-search huggingface dataset:
P08.42 Long-term treatment with Valganciclovir improves lentiviral suicide gene therapy for glioblastoma
Authors: J. Al Hossain, L. Ystaas, K. M. Talasila, K. Riecken, B. Fehse, R. Bjerkvig, H. Miletic
Journal: Neuro-Oncology (2017)

Previously we have shown that lentiviral vector mediated herpes simplex virus thymidine kinase (HSV-Tk) / ganciclovir (GCV) therapy is a very promising therapeutic option for GBM treatment. However, after long-term remission, tumor recurrence was observed in treated animals and interestingly a fraction of recurrent glioma cells expressed HSV-Tk. We hypothesized that short-term GCV treatment, which is used in clinical trials for suicide gene therapy of GBM, fails to eliminate a fraction of glioma cells which are slow-proliferating; thus, a longer period of prodrug administration might provide a better outcome. Here, we compared long-term treatment with the prodrug valganciclovir (valGCV), which is tailored for oral administration, to short-term treatment with GCV within the context of suicide gene therapy for experimental GBM. After orthotopic implantation of patient derived GBM spheroids and visible tumor growth on MRI, we injected lentiviral vectors expressing TK.007, a highly active mutant of HSV-tk. Animals were treated with either short-term GCV (3 weeks) or long-term valGCV (3 months). Although both treatment groups showed remission and subsequent tumor recurrence, animals in the valGCV treatment group survived significantly longer and had a longer recurrence-free time period. When analyzing the recurrent tumors, we observed that these were more invasive and less angiogenic compared to primary tumors in the control groups. Furthermore, recurrent tumors showed upregulation of tyrosine kinase receptor expression, in particular EGFR. These results open up the possibility for a combination treatment of lentiviral suicide gene therapy with tyrosine kinase receptor inhibitors in the future.
The changing image of the American physician
Authors: J. Duffy
Journal: JAMA (1967)

The high status that American physicians enjoy in present day society is largely a product of two factors, the broad application of science and technology to medicine and the advancing standard of living which has created a steadily increasing demand for medical services. This fortunate situation is of quite recent origin. Indeed, the 20th century was at hand before the art of medicine successfully united with science and technology to provide a sound basis for the profession. During much of American history, practitioners of medicine had relatively low status. In the colonial period, the most immediate problem arose from the acute shortage of properly trained medical men. While a great many Americans who trace their genealogy discover that their forefathers were aristocrats, nonetheless, the majority of settlers to the New World came from the lower economic groups. Physicians in 17th- and 18th-century Europe were trained in universities, a fact which
Cinema
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trilene as an Analgesic
Authors: F. N. Reynolds
Journal: BMJ (1948)

<b>Objective.</b> To identify and describe validated assessment tools measuring cultural competence relevant to pharmacy education. <b>Methods.</b> A systematic approach was used to identify quantitative cultural competence assessment tools relevant to pharmacy education. A systematic search of the literature was conducted using the OVID and EBSCO databases and a manual search of journals deemed likely to include tools relevant to pharmacy education. To be eligible for the review, the tools had to be developed using a study sample from the US, have at least one peer-reviewed validated publication, be applicable to the pharmacy profession, and be published since 2010. <b>Results.</b> The search identified a total of 27 tools from the systematic literature and manual search. A total of 12 assessment tools met the criteria to be included in the summary and their relevancy to pharmacy education is discussed. <b>Conclusion.</b> A review of literature demonstrates that assessment tools vary widely and there is no universal tool to assess cultural competence in pharmacy education. As cultural competence is a priority within the accreditation standards for Doctor of Pharmacy education, pharmacy programs are encouraged to develop additional tools that measure observed performance.
Society Proceedings
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase I/II dose-escalation study of weekly paclitaxel in combination with 5'-deoxy-5-fluorouridine for advanced or recurrent breast cance
Authors: H. Iwata, M. Mizutani, K. Kamei, T. Toyama, Y. Ando, D. Ota, N. Kawaguchi, C. Shigemori, H. Iwase
Journal: Journal of Clinical Oncology (2004)

698 Background: Paclitaxel is one of effective agents for breast cancer treatment. The weekly schedule of paclitaxel is a common regimen around the world. Oral 5'-deoxy-5-fluorouridine (5'-DFUR) is an intermediate metabolite of Capecitabine. Thymidine phosphorylase (dThdPase) is an essential enzyme for the activation of the cytostatics 5'-DFUR / Capecitabine to 5-fluorouracil in tumors. Paclitaxel reportedly increased dThdPase levels in tumors in vivo study. To assess the dose-limiting toxicities (DLT), maximum tolerated dose (MTD) and anti-tumor activity of paclitaxel in combination with 5'-DFUR in patients with advanced or recurrent breast cancer. Methods: Eligible patients had measurable and/or evaluable metastatic lesions and were aged 20–75 years with a WHO performance status of 0–1. Those who had taken paclitaxel before and had peripheral neuropathy were excluded. Dose escalation schema was shown below. The main toxicities (NCI-CTC version 2) in the dose-escalation step were as follows: Grade (G) 4 neutropenia (for 4 days), febrile neutropenia, G 4 thrombocytopenia and G 3 nonhematological toxicity without nausea and vomiting were considered to be dose limiting. Results: Fifteen patients with a median age of 56 years (range 43–69) were included. Anti-tumor activity was assessed in total 15 patients, as 2 CR, 5 PR, 2 NC, 4 PD and 2 NE (response rate; 46.7%). At Level 1, one of six patients had DLT (febrile neutropenia). However, six patients did not reach DLT at Level 2 and 3. Then two patients had DLT at Level4, so it was regarded as MTD. Conclusions: Weekly paclitaxel in combination with 5'-DFUR did not increase hematological and nonhematological toxicity. Level 4 (paclitaxel 100 mg/m2 and 5'-DFUR 1,200 mg/body) was MTD. We decided that the recommended dose is Level 3 (paclitaxel 80 mg/m2 and 5'-DFUR 1200 mg/body). No significant financial relationships to disclose.
Traité technique d'hématologie, morphologie, histogenèse, histophysiologie, histopathologie.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pruritus Ani
Authors: Neil W. Swinton
Journal: New England Journal of Medicine (1947)

A REVIEW of the voluminous literature on the subject of anal pruritus reveals that nearly as many theories regarding the etiology of this condition have been advanced and methods of treatment advocated as there have been authors. Several conclusions might be taken from this. First, the final answer has not been written, and there may be several etiologic factors involved in many of the patients with this condition. Secondly, because so many preliminary good results have been reported following so many apparently different types of therapy directed primarily toward the perianal region, the treatment of the patient, in addition to . . .
Alcohol Involvement in Pedestrian Fatalities— United States, 1982-1992
Journal: JAMA (1993)

Pedestrian deaths constitute the second largest category of motor-vehicle-related fatalities (following vehicle-occupant deaths) and account for 14% of all traffic-associated deaths and approximately 3% of all traffic-associated injuries. In 1992, 5546 pedestrians were killed and 96,000 were injured in traffic crashes (1,2). Alcohol is an important determinant for both the likelihood of a motor vehicle colliding with a pedestrian and the outcomes for pedestrians in crashes (3). This report summarizes data from the Fatal Accident Reporting System of the National Highway Traffic Safety Administration (NHTSA) on trends in alcohol use in traffic fatalities involving pedestrians in the United States during 1982-1992.
Effect of antihypertensive treatment on stroke recurrence. Hypertension-Stroke Cooperative Study Group
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Handbook of Pediatric Procedures.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Retrospect of Medicine.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea University Medical Library JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Computational Error
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shared Humanity
Authors: George Goshua
Journal: Annals of Internal Medicine (2017)

On Being a Doctor5 September 2017Shared HumanityGeorge Goshua, MDGeorge Goshua, MDFrom Yale–New Haven Hospital, New Haven, Connecticut.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-2602 Audio Reading - “Shared Humanity” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Shared Humanity," by G. Goshua. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail He is wearing his long overalls and a beige, straw rancher hat. A long beard descends to a point just above his navel. Robert drove in from a small rural town. At first glance, he seems thin and in good shape. I look further. Perhaps a bit too thin.I meet this man at the end of my first year of medical school. With an interest in surgery, I spend my time seeing patients in the hospital's ear, nose, and throat surgery clinic.The man speaks in a thick country accent. He takes off his hat and lifts his beard. ... Author, Article, and Disclosure InformationAffiliations: From Yale–New Haven Hospital, New Haven, Connecticut.Corresponding Author: George Goshua, MD, Yale–New Haven Hospital, 20 York Street, New Haven, CT 06511; e-mail, george.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Shared Humanity” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Shared Humanity," by G. Goshua. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 5 September 2017Volume 167, Issue 5Page: 359KeywordsEmotionsFirearm injuriesHead and neck cancersHospitalsOtorhinolaryngologyPostural controlShouldersSurgeonsSurgeryTouch ePublished: 5 September 2017 Issue Published: 5 September 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
β‐thalassemia and hemoglobin types in Argentina: Determination of most frequent mutations
Authors: Néstor W. Soria, Clara L. Tulián, François Plassa, German A. Roth
Journal: American Journal of Hematology (1997)

In order to know the spectrum of β-thalassemia alleles and other mutations affecting the β-globin gene, we analyzed the hemoglobin abnormalities in 24 patients from the Province of Córdoba in Argentina. Molecular screening of samples was performed by the polymerase chain reaction (PCR), using six sets of oligonucleotides to amplify fragments encompassing the whole β-globin coding region and splice junctions, as well as the promoter and 3′ untranslated regions. The altered fragments were determined by denaturing gradient gel electrophoresis (DGGE), and the corresponding mutations were identified by restriction enzyme analysis or by direct sequencing of PCR products. Using this approach, three different β-thalassemia mutations were detected, codon 39 (C→T), IVS-1-110 (G→A), and IVS-1-1 (G→A), and also the hemoglobin S trait. This is the first report of β-thalassemia mutations described in Argentina. Our results show that these mutations are similar to those found in Spain and Italy, possibly due to the important Mediterranean migratory stream received in our country, and could be important for prenatal diagnosis of these diseases in Córdoba, Argentina. Am. J. Hematol. 54:160–163, 1997 © 1997 Wiley-Liss, Inc.
Polycythemia Vera
Authors: C. Lockard Conley
Journal: JAMA (1990)

<h3>CASE PRESENTATION</h3> —Peter White, Jr, MD A 64-YEAR-OLD retired truck driver was brought to The Johns Hopkins Hospital after a transient episode of unresponsiveness. Ten days before admission, when he entered another hospital for treatment of acute polyarticular gout, he appeared plethoric and had an enlarged spleen. The hematocrit was 0.71, red blood cell volume was 81 mL/kg (normal, 25 to 35 mL/kg), and plasma volume was 33 mL/kg (normal, 30 to 45 mL/kg). Bone marrow was hypercellular without fibrosis. He was treated for gout and polycythemia vera. Within a week 1200 mL of blood was withdrawn and he was discharged. On the following day, he was found to be unresponsive, with twitching movements of his hands and feet. The episode resolved within a few minutes, but he was promptly brought to the emergency department, where results of neurological examination and a cranial computed tomographic scan were normal. The patient
Health Status of American Indians Compared With Other Racial/Ethnic Minority Populations—Selected States, 2001-2002
Journal: JAMA (2004)

Despite overall declines in morbidity and mortality in the United States in recent years, a persistent gap in health status remains between American Indians (AIs) and non-Hispanic whites. This report compares the health status of AIs with that of other racial/ethnic minority populations by using data from a survey conducted during 2001-2002 in 21 communities through the Racial and Ethnic Approaches to Community Health (REACH) 2010 project. The results indicate that although AIs had a higher prevalence of chronic disease risk factors than other racial/ethnic minority populations, they also were more likely to use preventive services. Culturally sensitive primary prevention strategies to reduce risk factors and disease burden in AI communities should be developed and implemented.
Rethinking the presence of American scholars in China
Authors: G. Henderson
Journal: JAMA (1990)

THE MASSACRE of Chinese students and citizens in Beijing last June shocked the world. Response was intensified by the almost instantaneous news coverage, which persisted until the Chinese government took control of the media. For Americans involved with research in China, the student uprising and the events in Tiananmen Square created tremendous pressure to articulate a position on China. As moral outrage turned to consideration of the long-term consequences of the events, a complex exchange among scholars, funding agencies, and government officials ensued.<sup>1</sup>Many US organizations and individuals suspended research plans as the implications of continued involvement in China—moral, political, and interpersonal—were debated. To some, June 4, 1989, marked a turning point in assessment of the Chinese regime. Cooperation and exchange that previously were acceptable now symbolized collaboration with a corrupt government. For me, the events that occurred in Tiananmen Square forced a reevaluation—not of current positions, but of