tbuckley/cabot-search huggingface dataset:
New Views on Diabetes Mellitus.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Partial Optic Nerve Atrophy in Lead Poisoning.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcutta Eye Infirmary
Authors: W. Martin
Journal: BMJ (1858)

IN the preceding division were put a certain number of cases exemplifying the disease as arising from a state of general debility of the system.We now come to examples of a con- dition of the retina, producing a nearly similar train of symptoms, but arising from a somewhat different cause; that is, a cachexia, caused not by mere excessive loss of the nutritious fluids of the body, but by some poisonous action exerted by the prevalence of a particular disease or train of diseases.CASE I. Jaddoo, aged 30, was admitted as an in-patient, September 27th, 1856, with amaurosis.The past year he had suffered from syphilis, for which he had been salivated.Two years previously he had enlarged spleen.He had become anasarcous, and had suffered from rheumatism.He saw objects as through a dense fog.There was slight strabismus.He was ordered tonic mixture, and counterirritation.October 6th.Ile was improving in both eyes.He after- wards suffered from cough, dyspepsia, etc., and was much benefited by the use of sarsaparilla.He also suffered from dysentery.
FURTHER FACTS ABOUT RICKETS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die spinale Kinderlähmung.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDU-34. PILOT STUDY OF A SURGERY AND CHEMOTHERAPY-ONLY APPROACH IN THE UPFRONT THERAPY OF CHILDREN WITH WNT-POSITIVE STANDARD RISK MEDULLOBLASTOMA
Authors: Kenneth Cohen, Pratiti Bandopadhayay, Susan Chi, Wendy London, Fausto Rodriguez, Cynthia Hawkins, Edward Yang, Dolly Aguilera, Robert Castellino, Tobey MacDonald, Stacie Stapleton, David Ashley
Journal: Neuro-Oncology (2019)

BACKGROUND: Molecular subclassification of medulloblastoma identifies Wnt-positive medulloblastoma (WPM) as a highly favorable subtype with event-free survival (EFS) exceeding 90% when treating patients following near total or complete resection with standard dose craniospinal irradiation and boost radiation to the posterior fossa (XRT) followed by adjuvant chemotherapy. This pilot study explored the safety of omitting XRT in children with standard-risk WPM. METHODS: Subjects had to meet usual standard-risk criteria (< 1.5 cm2 residual tumor, no metastatic spread, no anaplasia) and have a WPM. Initial criteria for determination of WPM included nuclear beta-catenin immunopositivity, monosomy 6 and absence of myc-amplification by FISH. Following the first two subject enrollments, criteria for WPM was revised to no longer require nuclear beta-catenin immunopositivity, and substituted gene-expression profiling by Nanostring. Upon consent, eligible subjects received adjuvant chemotherapy following the Children's Oncology Group ACNS0331 AAB-AAB-AAB (A=cisplatin/CCNU/VCR; B=cyclophosphamide/vincristine) backbone and followed for EFS. RESULTS: Fourteen children underwent prescreening of which six children who met molecular criteria for WPM elected to enroll on study treatment. Subject #1 completed planned protocol therapy, requiring a 50% reduction in cisplatin for most of therapy for ototoxicity, but relapsed 3 months following the completion of therapy. Subject #2 completed planned protocol therapy without dose reductions or delays, but relapsed 6 months following the completion of therapy. In both cases, relapse was local and disseminated. Following the second relapse, further accrual was halted. Of the remaining 4 subjects, two have recently completed protocol therapy and remain free of disease. The final two subjects are in the midst of protocol therapy. Additional therapy in the form of XRT and/or chemotherapy dose intensification has been recommended to these remaining 4 subjects. CONCLUSIONS: Chemotherapy following ACNS0331, in the absence of XRT, appears to be insufficient for the treatment of non-metastatic WPM.
Fundamental Immunology
Authors: Philip C. Anderson
Journal: JAMA (1990)

Medical readers, who demand much of those few books they choose to study for hours, will celebrate William Paul and this excellent exposition of modern immunology. Other book editors should look here to see how to do the job. Among all our colleagues, young and old, from all specialties, not many are able to teach up-to-date immunology. Most need to study—carefully, at leisure—from a book. This is the excellent book they need. To consider the best features of Paul's new edition: the authors are authoritative, and the presentations (writing and diagrams) are concise, understandable, and complete. Unlike most recent texts, this one has a satisfactory index. The bibliography is long, unusually well selected, and up-to-date on 1988 publications. For me, nothing in the book is so useful as a clever summary of all parts of the text presented as the first chapter and the key-concept lists at the top of
Breast Prostheses
Authors: Margaret Deanesly
Journal: JAMA (1976)

RECENTLY, public attention has been drawn more than ever to the problem of breast cancer. With Mrs Ford and Mrs Rockefeller both afflicted, more women are attempting self-examination. This surge of early detection and treatment will increase the number of women who will need prosthetic devices for many years of life. Consequently, the sensitive and skilled fitting of a well-accepted prosthetic device after mastectomy is possible and can mean the difference between prompt, cheerful, and total mobilization and long-term personal distress. When a breast surgery patient or her confidant asks you about these cosmetic and prosthetic devices there is much to be said. <h3>Who and Why</h3> Any woman who had protuberant breast tissue prior to surgery and has a unilateral mastectomy will need some device, if only to make her clothing fit properly. The larger the remaining breast, the more vital the need—not only for appearance but for weight. The
Rural health care. Medical issues
Authors: W. J. Kane
Journal: JAMA (1978)

Problems in the provision of health care to rural areas in the United States include the distribution of health workers, health care facilities, preventive services, quality of care, and economics. The problems must be clearly identified and defined if solutions are to be effective, and the cooperation of several sectors of the community is required. Community organization and political activity are often necessary to convince legislators and medical schools to assist rural communities in a solution of their major problems. (<i>JAMA</i>240:2647-2650, 1978)
CORRECTION
Authors: Z Sachetto, R Conde, A Samara, R Fernandes, S C B Costa, D Andrade, E Amstalden
Journal: Annals of the Rheumatic Diseases (2006)

Although finding B19 DNA the arterial tissue would not be enough to establish a causal link between this infection and PAN, this search is an important step in clarifying a possible role of B19 in the aetiopathogenesis of PAN.Hence, the hypothesis that a chronically persistent B19 infection in the endothelium can trigger vasculitis is very unlikely to apply to PAN and MPA.
Relationships between knowledge and experience in the use of disease-modifying antirheumatic agents. A study of primary care practitioners
Authors: J. K. Stross
Journal: JAMA (1989)

The timely dissemination of new medical information is a complex and often faulty process. We surveyed primary care physicians to determine their knowledge and use of disease-modifying antirheumatic agents for the treatment of rheumatoid arthritis. Only 26.2% of patients hospitalized for rheumatoid arthritis had been treated with disease-modifying antirheumatic agents in the past, and 13.9% were presently receiving them. When responding to a clinical vignette on rheumatoid arthritis, only 12% (10/84) of practitioners would implement therapy with disease-modifying antirheumatic agents, while the majority would refer the patient to a rheumatologist. Experience with similar patients was clearly the factor that led to initiation of therapy. While 73% of practitioners were aware of the value of disease-modifying antirheumatic agents, only 14% prescribed them in the last year. These findings suggest that dissemination of information concerning disease-modifying antirheumatic agents has been successful, but the problems inherent in their use result in referral rather than initiation of therapy. (<i>JAMA</i>. 1989;262:2721-2723)
LOUIS PASTEUR.
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P200: Optimal Phase Relationship Between Defibrillation and Manual Chest Compression Improves Shock Success
Authors: Yongqin Li, Hao Wang, Jun Hwi Cho, Weilun Quan, Gary Freeman, Joe Bisera, Max Harry Weil, Wanchun Tang
Journal: Circulation (2008)

Introduction A newly developed blanket provides the protection for rescuer from shock during cardiopulmonary resuscitation (CPR) and allow for uninterrupted chest compression. We examined relationships between the phase of manual compression and the timing of defibrillation based on measurement of the 50% defibrillation threshold (DFT50). Methods Ventricular fibrillation (VF) was electrically induced and untreated for 10 seconds in 8 domestic male pigs weighing between 22–31 kg. The depth and frequency of manual chest compression utilizing the isolated blanket initiated and continued for 25 seconds guided by a CPR prompter (iCPR, ZOLL Medical Corporation, Chelmsford, MA). A biphasic electrical shock of variable energies ranging from 30~150J was delivered at 5 phases of the compression period as shown in Figure 1–A . A group in which defibrillation was attempted at a constant 2 seconds following discontinued of chest compression served as a control. Results No difference between coronary perfusion pressures (CPP) prior to delivering of the shock were observed between the 6 groups. The calculated energy required for defibrillation, however, was significantly lower during the latter half of decompression as represented by group C and D (Figure 1–B ). Conclusion Defibrillation efficacy is maximal when an electrical shock is delivered during the latter phase of decompression.
Preliminary Clinical, Pharmacokinetic (PK) and Pharmacodynamic (PD) Results of the Safety Run In Part of a Phase II Trial of the Orally Available MEK-Inhibitor MSC1936369 In Patients with Advanced Hematological Malignancies
Authors: Farhad Ravandi, Arnaud Pigneux, Douglas Smith, Hervé Dombret, Xavier Thomas, Hagop M. Kantarjian, Jorge E. Cortes, Daniel J DeAngelo, Keith W Pratz, Ekaterine Asatiani, Athos Gianella-Borradori, Blandine Longerey, Jean-Luc Harousseau
Journal: Blood (2010)
Screening for Pediatric Lead Poisoning
Authors: Thomas L. Schlenker
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine the ability of capillary blood lead levels to accurately reflect true blood lead levels in children at risk for lead poisoning. <h3>Design.</h3> —A correlation study in which lead levels of capillary blood specimens obtained by four different methods were compared with lead levels of simultaneously drawn venous blood specimens. <h3>Setting.</h3> —A central-city pediatric primary care clinic and door-to-door home visits in one central-city neighborhood. <h3>Patients.</h3> —Two hundred ninety-five children at high risk for lead poisoning aged 6 months to 6 years. <h3>Main Outcome Measures.</h3> —Blood lead levels of simultaneously drawn capillary and venous blood specimens. <h3>Results.</h3> —Lead levels of all four capillary sampling methods were highly correlated (correlation coefficient ≥0.96) with matched venous blood lead levels, with mean capillary-venous differences less than 0.05 μmol/L (1 μg/dL). <h3>Conclusions.</h3> —Capillary sampling is an acceptable alternative to venipuncture for lead-poisoning screening in young children. (<i>JAMA</i>. 1994;271:1346-1348)
Prevalence of Parasites in Fecal Material From Chlorinated Swimming Pools--United States, 1999
Journal: JAMA (2001)

As a result of the 1998 outbreak of infection with the chlorine-sensitive pathogen Escherichia coli O157:H7 at a waterpark in Georgia, many public health departments updated their guidelines for disinfecting pools following a fecal accident. Many of these guidelines recommended treating all fecal accidents as if they contained the highly chlorine-resistant parasite Cryptosporidium parvum, generally resulting in hyperchlorination and pool closures of up to a day. To determine whether fecal accidents commonly contained Cryptosporidium, the prevalence of this parasite and the moderately chlorine sensitive parasite Giardia intestinalis was assessed by asking swimming pool operators throughout the United States to collect formed stools from fecal accidents in their pools. This report summarizes the results of this study and provides recommendations for disinfecting pools following fecal accidents.
Growth failure from maternal deprivation or undereating
Authors: M. F. Leonard
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The study on failure to thrive reported by Whitten et al as secondary to undereating (<b>209</b>: 1675, 1969) offers interesting data, but overlooks the implications of (1) its experimental methods, (2) its interpretations of observations, and (3) its conclusions. We question the ethics of submitting infants to two weeks of deliberate sensory deprivation in the hospital. The fact that they gained weight as well in this setting as they did when "mothering" was added, does not justify the exposure of admittedly deprived children to an environment which they say: "virtually duplicated.. environments that produced classic effects of maternal deprivation, ie, suppression of affect, and developmental and intellectual retardation." We are not told enough of the psychological or developmental effects, but the authors write, "No adverse effects were noted from the understimulation. There was little crying and little effort to engage the nurse." Thus the infants were already
Autologous blood donation
Authors: P. M. Kempen
Journal: JAMA (1988)

<h3>In Reply.</h3> —What we are witnessing in the previous two letters is a Mexican standoff. To this observer, the message is clear: superb yeast-derived vaccines have been developed by talented researchers from each of these reputable companies. There is every reason to believe that such vaccines will provide comparable protection against hepatitis B. The reduced immune response initially observed with early lots of Recombivax-HB<sup>1,2</sup>compared with plasma-derived vaccine apparently has been rectified by Merck Sharp &amp; Dohme through improvements in their manufacturing process and through the use of a new master seed lot (Table 2, "New/improved" column). I applaud these modifications since the "margin of safety with regard to potency" has been improved. Because of this, product selection is less of an issue. Research efforts now should be directed toward the nonresponders, that small group of individuals who fail to mount an immune response to the current vaccines and
Mitochondrial profiling as a predictive biomarker for response to cytarabine-based treatment of acute myelogenous leukemia.
Authors: E.J. Dettman, Camille Doykan, Michael H. Cardone, Robert Hills, Paul White, Alan Kenneth Burnett, Michael Andreeff
Journal: Journal of Clinical Oncology (2016)

7017 Background: Acute Myelogenous Leukemia (AML) remains a poorly treated disease, which personalized medicine may improve by identifying the best therapy option based on a patient’s molecular or genetic makeup. To date, the best biomarkers in AML are based on cytogenetic risk category and age; however, these characteristics cannot accurately identify the best treatment option and are prognostic rather than predictive. One of the most promising predictive tests in AML involves the measurement of apoptotic sensitivities, as mitochondrial apoptosis induction is a hallmark for response to many treatment modalities. Methods: Mitochondrial profiling involves the perturbation of cells with specific BH3 (BCL2 Homology Domain 3) peptides, followed by flow cytometric measurements of their response in terms of induction of apoptosis. This method can be used to identify specific blocks of apoptosis present in leukemias at the single cell level. In a previous study, we identified that those AML patients most likely to respond to high dose ara-C (HiDAC) were highly primed for the BIM BH3 peptide. Here, we examined the relationship between BIM priming and complete remission (CR) and overall survival (OS) in patients treated with a standard ara-C based 7+3 regimen. Results: As with HiDAC treated patients, CR to 7+3 was significantly associated with BIM priming (p = 0.05), showing that it is an excellent predictor of response to the 7+3 regimen. BIM priming was also associated with longer OS (p = 0.049), with a positive predictive value of 80% and a negative predictive value of 70% using this single biomarker test. Additionally, BIM priming was additive to the cytogenetic risk category and age in predicting response, suggesting that BIM priming captures an additional dimension of AML biology that was not measured with cytogenetics and age. The BIM peptide has a broad binding range among the BCL-2 family members suggesting a general sensitivity to pro-apoptotic stimuli in the responsive leukemias. Conclusions: These results demonstrate that response and favorable outcomes are associated with the BIM biomarker, and this test can be used to identify patients that are most likely to respond to ara-C based therapies.