tbuckley/cabot-search huggingface dataset:
Abstract 21349: Characteristics of Patients at Increased Risk of Serious Adverse Events While Receiving Intensive Blood Pressure Therapy: Post-Hoc Analysis of the SPRINT Trial
Authors: Setri Fugar, Alexis Okoh, Ahmed Al-Ogaili, Ali Ayoub, Noble Vondee, Parth Desai, Abhushan Poudyal
Journal: Circulation (2017)

Background: Intensive blood pressure management is associated with decreased overall incidence of myocardial infarction, stroke and hospitalization for heart failure among non-diabetic patients though with several associated adverse events (SAEs). The present study aimed to identify patients who are at increased risk of having adverse events while on the intensive blood pressure therapy. Methods: Data from the SPRINT trial was analyzed. Study participants who were in the intensive arm of the trial were divided into two groups based on the outcome of SAEs as defined per trial protocol. Baseline characteristics of the patients in both groups were compared using chi-square analysis. Logistic regression models were used to determine factors associated with developing a SAE while on the intensive therapy. Results: Out of 4678 patients who received intensive therapy, 1684 (36.0%) were females. The mean ± SD age was 67.9 +/- 9.4 years. The incidence of SAEs was 38.3% (n=1793). On multivariable analysis, factors associated with developing a SAE were found to Age (OR per unit change 1.04, 95% CI: 1.03-1.05 p-value: &lt;0.001), Creatinine (OR/unit change 1.59, 95% CI: 1.12-2.26 p-value: 0.0094), Smoking (1.50, 95% 1.22-1.85, p-value:0.0001), BMI (OR/unit change 1.03,95% CI 1.02-1.04 p-value &lt;0.001), urine microalbumin (numbers?) and the more medications the increased the risk of adverse outcomes. Conclusion: Intensive blood pressure management is associated with improved cardiovascular outcomes, however factors such as older age,high creatinine levels and a positive history of smoking are associated with developing serious adverse events. .
Mutation as Cellular Process.
Journal: Annals of Internal Medicine (1970)

Book reviews of the coagulation defect in the report of knowledge of the abundant systematized the Medical Research Council's trial of and well studied human tumours with anticoagulants in acute myocardial in-which they are comparable.There are farction presented for the first time at this also sections on tumours induced by meeting are thus not recorded.Likewise, radiation and other methods.It is an intro- Professor Mitchell's outspoken comments duction to the subject for the general on computerized data, which was one of reader with veterinary interests rather than the focal points of the session, are lost.a supplement to the well known majorThe wisdom of publication in full of texts on bone tumours available for papers presented at meetings is always specialists.There is a compendious biblio- questionable, but the editors and dis-graphy.The radiographs and clinical tinguished contributors to this volume pictures of animal tumours are of high have produced a publication which ranks quality and likely to be unfamiliar to as one of the best of its class.medical, as opposed to veterinary, L. POLLER pathologists.A. LEVENE
GONE FISHING
Authors: Phillip J. Cozzi
Journal: Annals of Internal Medicine (1995)

Ad Libitum15 December 1995GONE FISHINGPhillip J. Cozzi, MDPhillip J. Cozzi, MDElmhurst, IL 60126Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-12-199512150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Billie left for Florida the night beforebronchoscopy was planned. Red snapper, bass,tarpon, grunt, and grouper swam the shoreas they had always. Mangroves borethe waves, remained for centuries in place,but Billie left for Florida. The night beforehe left was like all others, moreor less: the bluecrab crawled, dolphin passed,tarpon, grunt, and grouper swam, the shoreheld fast, and bloodless creatures scraped the floorsof seas they've always coursed. Alas,Billie left for Florida. The night beforehim snapped like line; a tarpon soaredto lightless depths to die with hook in place,while grunt and grouper swam the shore.In partly dying too, ... Author, Article, and Disclosure InformationAffiliations: Elmhurst, IL 60126 Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1995Volume 123, Issue 12Page: 960KeywordsBronchoscopy ePublished: 15 August 2000 Issue Published: 15 December 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
FRI0503 Eular-Pres Points to Consider for the Use of Imaging in the Diagnosis and Management of Juvenile Idiopathic Arthritis in Clinical Practice
Authors: A.N. Colebatch-Bourn, C.J. Edwards, P. Collado, M.A. D'Agostino, R. Hemke, S. Jousse-Joulin, M. Maas, A. Martini, E. Naredo, M. Østergaard, M. Rooney, N. Tzaribachev, M. van Rossum, J. Vojinovic, P.G. Conaghan, C. Malattia
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To develop evidence based points to consider on the use of imaging in the diagnosis and management of juvenile idiopathic arthritis (JIA) in clinical practice. <h3>Methods</h3> The task force comprised an expert group of adult and paediatric rheumatologists, radiologists, and methodologists from 9 countries. Eleven key questions on the role of imaging in JIA were generated using a process of discussion and consensus. Imaging modalities included were conventional radiography (CR), ultrasound (US), magnetic resonance imaging (MRI), computed tomography (CT), scintigraphy and positron emission tomography (PET). Research evidence was searched systematically for each question using MEDLINE, EMBASE and Cochrane CENTRAL. The experts used the evidence obtained from the relevant studies to develop a set of points to consider. The task force assessed their level of agreement with each point to consider using a numerical rating scale. Quality assessment of the included studies was performed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 tool. <h3>Results</h3> A total of 13,277 references were identified from the search process, from which 204 studies were included in the systematic review. Nine points to consider were produced encompassing the role of imaging in making a diagnosis of JIA, detecting and monitoring inflammation and damage, predicting outcome and response to treatment, use of guided therapies, progression and remission (table). The level of evidence, grade of recommendation and level of agreement for each proposition are given in the table, and vary according to both the research evidence and expert opinion. <h3>Conclusions</h3> Nine key points to consider for the role of imaging in the management of JIA were developed using research based evidence and expert opinion. <h3>Disclosure of Interest</h3> None declared
RECURRENCE IN CANCER.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemic streptococcal sore throat following a community picnic
Authors: J. B. McCormick
Journal: JAMA (1976)

Following a picnic, nearly half of the persons who attended became ill. Sixty-three of 139 throat cultures were positive for group A β-hemolytic streptococci. Forty-seven of the positive cultures were available for typing, 34 of which harbored the epidemic strain, group A β-hemolytic<i>Streptococcus</i>type T-3/13/B3264. This contrasted with two of 204 controls who had not attended, but harbored the epidemic strain. Food preferences and illness rates implicated the potato salad, and from it the epidemic strain was isolated. The attack rate and case-to-infection ratio among those who attended the picnic was significantly greater for persons over 10 years of age. Prompt institution of chemoprophylaxis could possibly have prevented at least 50% of the cases. (<i>JAMA</i>236:1039-1041, 1976)
Diets for Gastrointestinal Disorders-Reply
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Host Reactions" in Gastric Cancer: Preliminary Study of 119 Cases of Gastrectomy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Propédeutique obstétricale
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stability of renal transplant function with alternate-day corticosteroid therapy
Authors: R. V. Breitenfield
Journal: JAMA (1980)

Fifty-three renal transplant recipients with good to excellent renal function, while receiving daily maintenance or near-maintenance doses of azathioprine and methylprednisolone, were gradually converted to alternate-day corticosteroid therapy. Stability of allograft glomerular filtration rate (GFR) in each patient was assessed by calculating the slope of a plot of the reciprocal of the serum creatinine concentration vs time. After conversion to alternate-day therapy, GFR was stable in 80% but deteriorated in 20% of patients. However, most of the patients who experienced deteriorating GFR during alternate-day therapy regained stable renal function when given the same total corticosteroid dose but on a daily basis. This suggests but does not prove that maintenance-level daily corticosteroid therapy is better than maintenance-level alternate-day therapy in stabilizing allograft function. We conclude that maintenance-level alternate-day corticosteroid therapy should be used cautiously until a long-term prospective study determines whether there is an increased risk of losing renal function with this schedule and whether this potential risk is offset by reduced corticosteroid toxicity. (<i>JAMA</i>244:151-156, 1980)
Abstract 4046: Immune repertoire sequencing reveals tumor microenvironment and tracks clonally expanded B cell and T cell in blood
Authors: Chen Song, Pingfang Liu, Andrew Barry, Bradley W. Langhorst, Fiona J. Stewart, Salvatore Russello, Theodore B. Davis, Eileen T. Dimalanta
Journal: Cancer Research (2019)

Abstract The study of complex immunological diseases and tumor microenvironments has progressed through recent developments on sequencing of the immune repertoire. Using this approach, the interrogation of disease progression is facilitated through analysis of millions of V(D)J combinations from B cell antibodies (Igs) and T cell receptors (TCRs). One major challenge of immune repertoire sequencing is to accurately capture the structural and sequence complexities of antibodies and TCR genes. We have developed a method for accurate sequencing of full length immune gene repertoires of B cells and T cells. RNA extracted from tumor tissues containing tumor infiltrating lymphocytes, as well as matched peripheral blood mononuclear cells (PBMCs) were used to generate full length Ig and TCR libraries. Unique molecule index (UMI) was used to discretely barcode each mRNA molecule, enabling absolute quantitative ranking of antibody/TCR clone abundance. Full length immune repertoire sequencing facilitates detection of distinct and shared clones in tissue and blood samples, enabling identification of disease specific clones to evaluate immunotherapy effects. Highly expanded clones in tumor samples are also found in blood samples. RNA-seq libraries were also constructed from the same RNA for Ig and TCR libraries. The expression level of IGH/IGL/IGK and TRA/TRB in the immune sequencing libraries highly correlates with the RNA-seq data. In addition, both Ig and TCR libraries can be constructed in one tube to obtain a whole immune repertoire profile.Our immune repertoire sequencing approach allows accurate clonal determination for both Ig and TCR. This technique is applicable for investigation of lymphocytes infiltration of tumor microenvironments, tracing expanded B cell and T cells in blood samples, and monitoring of minimal residual disease. Citation Format: Chen Song, Pingfang Liu, Andrew Barry, Bradley W. Langhorst, Fiona J. Stewart, Salvatore Russello, Theodore B. Davis, Eileen T. Dimalanta. Immune repertoire sequencing reveals tumor microenvironment and tracks clonally expanded B cell and T cell in blood [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4046.
Persistence of occult metastatic cells in bone marrow after adjuvant systemic therapy predicts relapse in localized breast cancer
Authors: B. Bermejo, A. Lluch, I. Benet, J. M. Sastre, J. V. Ferrer, T. Garcia, L. Chumbes, P. Martinez, J. Garcia-Conde
Journal: Journal of Clinical Oncology (2004)

657
Arch Int Pharmacodyn et Therapie, Ghent
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Herpes Progenitalis
Authors: Peter J. Lynch
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The "minor" venereal diseases—lymphogranuloma venereum, granuloma inguinale, chancroid—have lately assumed greater importance owing to the increased number of soldiers returning from Vietnam. It has now become important for the "stateside" physician to recognize and treat these conditions. Recently, it has come to our attention that one of these diseases, chancroid, is being frequently misdiagnosed in Vietnam and that this mistake is being propagated in the United States. Within a four-week period, six patients were seen in our venereal disease clinic with "recurrent" or "incurable" chancroid, originally diagnosed as such in Vietnam. On examination each patient was found to have characteristic herpes progenitalis of the penis. A typical case history is as follows: In a 21-year-old white soldier, multiple erosions of the prepuce developed in June 1967 while in Vietnam. Results of a dark field examination were normal, as were the results of the serologic test for syphilis,
Decompression Sickness: Caisson Sickness, Diver's and Flier's Bends and Related Syndromes
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plastic bronchitis
Authors: JY Park, AA Elshami, DS Kang, TH Jung
Journal: European Respiratory Journal (1996)

Plastic bronchitis is generally associated with some type of pulmonary disease and improves either spontaneously or with medical therapy. We present a case of plastic bronchitis with no known cause. The patients' symptoms were not responsive to medical therapy but were relieved after right middle lobectomy.
COMPLEMENT-FIXING ANTIBODIES IN HEALTHY SUBJECTS
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hydrocortisone and Treatment of Multiple Trauma
Authors: Jorge I. F. Salluh, Pedro Póvoa
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal