tbuckley/cabot-search huggingface dataset:
Edna
Authors: Stacy Nigliazzo
Journal: Annals of Internal Medicine (2010)

Ad Libitum19 January 2010EdnaStacy Nigliazzo, BS, RNStacy Nigliazzo, BS, RNFrom Bryan, TX 77808.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-2-201001190-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail She wears her straw-stitchedyellow hat proudly,a silk rose bloomingon the weathered brim.Rope-beltedblue-green coverallstucked with eighty-five yearsin her back pocket.Called a cab instead of her daughteror the neighbors—I just tripped on a tomato plant is all,it's not like it's a stroke or somethin', she quips.Hands her nurse three perfectly foldedplastic freezer bags—Use these for the ice pack, hon, she directs,propping her purple ankle atopthe locking metal siderail.Time for your x-ray, ma'am,the technician proclaims,rolling back the flowering exam curtain.Just a minute, young man, she interjects—pulling a silver compact from her purse,painting ... Author, Article, and Disclosure InformationAffiliations: From Bryan, TX 77808.Current Author Address: Stacy Nigliazzo, BS, RN; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 January 2010Volume 152, Issue 2Page: 130KeywordsAnklesNursesStrokeTechnicians ePublished: 19 January 2010 Issue Published: 19 January 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Scientists seek to gain adherents, avert technological ignorance 'disaster'
Authors: M. F. Goldsmith
Journal: JAMA (1989)

EVERY CHILD is a natural scientist, filled with curiosity and eager to experiment, agreed participants in "Strategies for Change," a science literacy planning symposium organized by the American Medical Association (AMA) and seven other scientific societies. The poser is, why do so few in the United States sustain into adulthood sufficient interest in how the world works to propel them into scientific careers? Have insensitive parents and inadequate teachers squelched untold numbers of budding mathematicians and researchers? Does intimate acquaintance with the culture of poverty preclude caring about biological cultures? Is the affluence seemingly promised by business and the law luring analytical minds away from chemistry and physics? Can the entertainment industry's portrayal of white-coated scientists as evil or "weird" or "nerds" be blamed for discouraging the "regular guys"? Not to mention the many prospective technologists who aren't guys at all—and how many women engineers do<i>you</i>know? These questions
Cancer events in Belgian nursing home residents (NHR): An EORTC prospective cohort study.
Authors: Hans Wildiers, Monique Elseviers, Murielle E. Mauer, Jonas de Wolf, Edith Bastiaens, Sigrid Hatse, Marije Hamaker, Frank Buntinx, Jan de Lepeleire, Geert Uytterschaut, Konstantinos Tryfonidis, Maryska Janssen-Heijnen
Journal: Journal of Clinical Oncology (2017)

e13066 Background: A large prospective cohort study was designed to describe cancer events, referral patterns, anticancer treatments and outcome in NHR. Methods: The study was set up in 39 nursing homes from the Armonea network in Belgium, covering 4262 nursing home beds. Cancer events were defined as a new cancer event (new cancer or progressive disease of a previously known cancer) where a diagnostic/treatment decision had to be taken; and patients with strong clinical suspicion (physician’s judgement) of a new cancer event, but where the decision was made not to take further diagnostic/therapeutic steps. Cancer events in NHR were collected during a 1y-period in these 39 nursing homes. After training, each site’s local staff identified patients with cancer events in collaboration with the treating general practitioner (GP). NHR were included after informed consent, and relevant data, including a questionnaire for the GP at baseline, were recorded at least every 3 months up to 2 years. Results: The study was open from 3-2015 till 3-2016 in 37 nursing homes (and 2 pilot nursing homes started and stopped 6 months earlier). In only 9 NHR (median age 87y, range 72-92), cancer events were recorded during this period (incidence rate = 222/100,000 NHR per year). The 9 tumor cases were: one strong clinical suspicion of new prostate cancer, and one undefined cancer; a strong clinical suspicion of breast cancer progression; 3 newly diagnosed cancers (angiosarcoma of the breast, head and neck plus gingiva cancer, and one undefined) ; 3 cases with diagnosed progression of a previously known tumor (skin cancer, head and neck cancer plus skin cancer, bladder cancer). During follow-up, 6/9 NHR died, with a median overall survival of 5 Mo (range 2-16 Mo). Further details on diagnostic/therapeutic approach and outcome are pending. Conclusions: This study evaluated for the first time cancer events prospectively in a large nursing home population. Clinically relevant cancer events occur at a much lower frequency in NHR than expected from cancer incidence data in the general older population, supporting several previous retrospective observations that cancer events are much less frequent and problematic in very frail older persons than previously expected. Clinical trial information: NCT01910376.
Neoplastic Meningitis
Authors: Marc C. Chamberlain
Journal: Journal of Clinical Oncology (2005)

Neoplastic meningitis (NM) is a common problem in neuro-oncology occurring in approximately 5% of all patients with cancer, and is the third most common site of CNS metastases. NM is a disease affecting the entire neuraxis, and therefore clinical manifestations are pleomorphic affecting the spine, cranial nerves, and cerebral hemispheres. Because of craniospinal disease involvement, staging and treatment need to encompass all CSF compartments. Treatment of NM utilizes involved-field radiotherapy of bulky or symptomatic disease sites and intra-CSF drug therapy. The inclusion of concomitant systemic therapy may benefit patients with NM and may obviate the need for intra-CSF chemotherapy. At present, intra-CSF drug therapy is confined to three chemotherapeutic agents (ie, methotrexate, cytarabine, and thiotepa) administered by a variety of schedules either by intralumbar or intraventricular drug delivery. Although treatment of NM is palliative with an expected median patient survival of 2 to 6 months, it often affords stabilization and protection from further neurologic deterioration in patients with NM.
Observations Suggested by the Study of Cases of Cataract Extraction
Authors: C. Taylor
Journal: BMJ (1868)

pain and vomitilno.The symptoms becam-e more urgent as the day ad- vanceci; and, in spite of treatment, she sank and died at one o'clock on the morning of the 2'rd, after an illness not exceeding twventy-two hours.'The follow in, cie txc vztw/c-mz appearances.Thleabdkomen s-as distended; there w rA fotr pints of bloody seruim in the cavity of the
DIABETES MELLITUS IN HAWAII
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eye Mass
Authors: Roomasa Channa, Amanda Kiely, Fasika A. Woreta
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical News
Journal: JAMA (1975)

<h3>Gene-grafting experiments produce both high hopes and grave worries</h3> Science is approaching the point where it soon might become possible, for example, to graft the genes for chlorophyll synthesis on an animal cell and stand back to see what happens. No one knows, and there are no real precedents for predicting the possible outcome of such experiments. Their possible benefits and dangers, in fact, are truly mind-boggling. As a result, even though the techniques for such work have only recently been worked out, debates have begun and grown intense on many grounds, involving safety and purpose of the experiments as well as moral and legal questions. The scientific world was jolted last summer by a letter to<i>Science</i>that called for a voluntary moratorium on certain experiments because of the possible hazards involved in linking DNA from different species. The letter led to a meeting in February of this
Malignant mesenchymoma of pleura in infancy. Report of a case
Authors: D. B. Darling
Journal: JAMA (1967)

THE term "mesenchymoma" is usually used to denote a rapidly growing, undifferentiated mesenchymal tumor offering a very poor prognosis. It is a common tumor in infancy. Its cells may be completely undifferentiated or in places may show varying types and degrees of cellular differentiation. Such a tumor, arising in the pleura, is the subject of this paper. No similar case has been found in the literature. <h3>Report of a Case</h3> A 3-month-old female infant was admitted to the Boston Floating Hospital with a history of hemothorax on the right. The infant had apparently been in good health until two days prior to admission. Heavy and rapid breathing suddenly developed and this was associated with expiratory grunting. There was an absence of breath sounds and there was dullness to percussion on the right. The temperature was 101 F (38.3 C). An x-ray film of the chest showed fluid in the right
Hibakusha
Authors: William J. Hall
Journal: Annals of Internal Medicine (2008)

On Being a Doctor5 February 2008HibakushaWilliam J. Hall, MDWilliam J. Hall, MDFrom University of Rochester School of Medicine, Rochester, NY 14620.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-3-200802050-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The clinic is at the summit of Hijiyama Hill, one of the highest elevations overlooking the city of Hiroshima. Halfway up the winding road, I pass a turnout that had been a favorite site for reconnaissance teams to obtain the first panoramic photographs of the city in August 1945. The 7 branches of the Ota River, demarcating the 6 island neighborhoods of the city, are starkly visible in those old pictures, as if on a topographical map. Not a building had been left standing seconds after “Little Boy” detonated 580 meters over the city. Since then the city has been ... Author, Article, and Disclosure InformationAffiliations: From University of Rochester School of Medicine, Rochester, NY 14620.Corresponding Author: William J. Hall, MD, Highland Hospital, 1000 South Avenue, Box 58, Rochester, NY 14620; e-mail, [email protected]rochester.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 February 2008Volume 148, Issue 3Page: 241-242KeywordsGlobal healthHand strengthHealth surveysMedical educationPoliomyelitisPrevention, policy, and public healthRadiation exposureRiversSocial phobiaTriage ePublished: 5 February 2008 Issue Published: 5 February 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Modulation of Tumor Promotion in Liver Carcinogenesis
Authors: Hisashi Shinozuka, Samuel E. Abanobi, Benito Lombardi
Journal: Environmental Health Perspectives (1983)

Earlier, we demonstrated that feeding to rats a diet devoid of choline, a lipotropic factor, markedly enhances hepatoma induction by several chemical carcinogens, and that the diet acts as a strong promoter of the evolution of initiated cells to foci of altered hepatocytes. The ability of several factors to modulate the action of the choline-devoid (CD) diet as a promoter was investigated by quantitating the foci of gamma-glutamyl transpeptidase-positive hepatocytes developed in rats exposed to a single injection of diethylnitrosamine. Addition to the diet of phenobarbital (PHB) resulted in a promoting action stronger than those of the CD diet or of PHB alone. Two other barbiturates, amobarbital (AMB) and pentobarbital (PTB) exerted an effect similar to that of PHB, while barbituric acid (BA) had no effect. In other studies, lowering the fat content of the CD diet reduced its efficacy as a promotor, while the addition of a hypolipidemic agent, BR931, 4-chloro-6-(2,3 xylidino)-2-pyrimidinylthio (N-beta-hydroxy-ethyl)acetamide, completely abolished the promoting action of the CD diet. In rats not exposed to carcinogen, feeding the CD diet caused a marked enhancement of liver DNA synthesis and of cell proliferation. Inclusion of PHB, PTB or AMB in the CD diet inhibited these effects, while BA exerted no inhibition. The increased rate of DNA synthesis and cell proliferation in the liver were not affected by the level of fat in the CD diet. These results suggest that beside a stimulation of liver cell proliferation, other factor(s) determine the efficacy with which a CD diet exerts its promoting action.
Not Antitoxin.
Authors: F. W. Reilly
Journal: JAMA (1896)

Chicago, July 13, 1896. <h3>To the Editor:</h3> —In theJournalof 11th inst. p. 113, appears the following: "Another Death from Antitoxin.—Dr. W. J. Nolan of Chicago, writes the following to the New York<i>Medical Journal:</i> "285 Loomis St., Chicago, June 24, 1896. "To the Editor of the New York<i>Medical Journal: Sir:</i>— In view of the discussion now going on in the<i>Journal</i>, of which I have been three years a reader and subscriber, I frankly indorse the views of Dr. Winters in regard to antitoxin in diphtheria. Of one case I must write in terms of strong condemnation. The facts are as follows: I was called to see a boy, 8 years old, pulse rapid, temperature 105 degrees, and the laryngeal appearance quasi-diphtheritic. I began the ordinary treatment, in which quinin, carbolic acid and iron formed chief parts. The result next morning was very satisfactory; all alarming
New Allergy Society, Formed to Advocate In Vitro Laboratory Test, Wins Reimbursement Victory
Authors: Paul Cotton
Journal: JAMA (1990)

A SOCIETY formed to promote in vitro allergy testing has won approval for the controversial technology from Blue Cross and Blue Shield. "The Blues' decision at the top level indicates that this test is reasonable, the cost-benefit ratio is reasonable, the way it is being done is not abusive, and it contributes to patient care," says American In Vitro Allergy and Immunology Society president-elect Russell Williams, Jr, MD. However, the national Blues' statement is only "informational." Independent local plans that are considering a change in their own reimbursement policy are bound to hear reservations from other allergists. The technology "just is not at the point yet where we're ready to shift," says Donald Aaronson, MD, immediate past president of the American College of Allergy and Immunology. And in declaring in vitro tests "eligible for coverage," the Blues' revised Uniform Medical Policy statement equates them to other widely used but controversial
Abstract 4074: Prostaglandin E2 promotes intestinal tumor growth via DNA methylation
Authors: Dianren Xia, Dingzhi Wang, Sun-Hee Kim, Hiroshi Katoh, Raymond N. DuBois
Journal: Cancer Research (2012)

Abstract Both chronic inflammation and DNA methylation have been implicated as early events during colorectal cancer (CRC) carcinogenesis. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk for colorectal cancer (CRC) by 40-50%. NSAIDs exert some of their anti-inflammatory or anti-tumor effects by inhibiting prostaglandin-endoperoxide synthase (PTGS) 1 and 2. PTGS2-derived prostaglandin E2 (PGE2) is a pro-inflammatory mediator and promotes tumor progression. Promoter DNA methylation may promote tumor growth through silencing tumor suppressor or DNA repair genes. Whether chronic inflammation, specifically in this study the pro-inflammatory factor PGE2, plays a role in DNA methylation and contributes to CRC carcinogenesis is unknown. Here we demonstrated that PGE2 upregulated DNA methyltransferase (DNMT) 1 and 3B, which resulted to increased DNA methylation in the promoters of target genes O6-methylguanine-DNA methyltransferase (MGMT), cannabinoid receptor 1 (CNR1), CDKN2B, and MutL homolog 1 (MLH1) in CRC cell lines. Meanwhile, the expression of MGMT, CNR1, CDKN2B, and MLH1 were decreased. EP4 antagonist blocked the upregulation of DNMT1 and DNMT3B while knockdown of DNMT1 or DNMT3B attenuated the dwonregulation of MGMT, CNR1, CDKN2B, and MLH1 by PGE2 in LS-174T cells. In ApcMin/+ mice, PGE2 treatment also increased the expression of DNMT1 and DNMT3B and the DNA methylation of MGMT, CNR1, CDKN2B, and MLH1 promoters, and reduced their expression. All these alterations were accompanied by increases in both polyp number and size in the intestines of ApcMin/+ mice. More intriguingly, a demethylating agent 5-Aza-dC blocked the PGE2-induced DNA methylation and tumor growth in ApcMin/+ mice. And a combination treatment with a selective PTGS2 inhibitor celecoxib and 5-Aza-dC more effectively reduced the polyp number and size in ApcMin/+ mice in comparison with either single agent. Furthermore, the levels of PTGS2 and PGE2 correlated with the expression of DNMT1 and DNMT3B; The DNA methylation of MGMT, CNR1, and MLH1 correlated with the levels of PTGS2, PGE2, DNMT1, and DNMT3B in human colorectal carcinomas. These results suggest that PGE2 can silence tumor suppressor or DNA repair genes via DNA methylation to promote CRC carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4074. doi:1538-7445.AM2012-4074
Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertensionThe study on cognition and prognosis in the elderly (SCOPE)
Authors: V PAPADEMETRIOU, C FARSANG, D ELMFELDT, A HOFMAN, H LITHELL, B OLOFSSON, I SKOOG, P TRENKWALDER, A ZANCHETTI
Journal: Journal of the American College of Cardiology (2004)
Endocrinology
Authors: D. L. Loriaux
Journal: JAMA (1992)

Fuller Albright was the first to suggest, in 1940, that osteoporosis in menopause was, in part, due to estrogen deprivation. Across the intervening years, the response to this intelligence has been a desultory and inconsistent recommendation for estrogen replacement therapy. However, recent research findings provide evidence for a new and compelling role for hormonal replacement therapy (HRT) in menopausal women. Most dramatic is the somewhat unexpected effect of HRT on the incidence of cardiovascular deaths in menopausal women. Cardiovascular events are the most common cause of death in this group of women. In the United States this amounts to about 250 000 deaths per year. Recent evidence suggests that this cause of death can be reduced by half with HRT, an immense impact on the public health.<sup>1</sup>The mechanism of this effect is not yet clear. Although there is a measurable effect on the plasma lipid profile, the magnitude
Diagnosis And Treatment of Hæmorrhoids and other Non-malignant Rectal Diseases.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Therapy of the Neuroses and Psychoses: A Socio-Psycho-Biologic Analysis and Resynthesis
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal