tbuckley/cabot-search huggingface dataset:
Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients
Authors: A Khoruts
Journal: Hepatology (1991)

Although altered cytokine homeostasis has been implicated in the pathogenesis of alcoholic liver disease, the relationship between cytokines and metabolic consequences of alcoholic liver disease is unknown. We, therefore, sought to correlate circulating concentrations of tumor necrosis factor-α, interleukin-1 and interleukin-6 to clinical and biochemical parameters of liver disease in chronic alcoholic patients. We used an enzyme-linked immunosorbent assay to measure plasma tumor necrosis factor and interleukin-1 and a bioassay to measure serum interleukin-6 in three groups of alcoholic men as follows: (a) actively drinking alcoholic men without evidence of chronic liver disease, (b) nondrinking alcoholic men with stable cirrhosis and (c) patients with acute alcoholic hepatitis. Mean cytokine concentrations were elevated in cirrhotic patients and alcoholic hepatitis patients compared with controls and alcoholic patients without liver disease. Tumor necrosis factor-α and interleukin-1α concentrations remained elevated for up to 6 mo after diagnosis of alcoholic hepatitis, whereas interleukin-6 normalized in parallel with clinical recovery. Concentrations of all three cytokines were correlated with biochemical parameters of liver injury and hepatic protein synthesis plus serum immunoglobulin concentrations. We could not demonstrate a relationship between cytokine concentrations and peripheral endotoxemia. Percentages of peripheral blood monocytes that reacted with monoclonal antibodies to CD25 (interleukin-2 receptor) and human lymphocyte antigen-DR were similar for alcoholic patients and controls. These data suggest that tumor necrosis factor-α and interleukin-1α are related to some of the metabolic consequences of both acute and chronic alcohol-induced liver disease, whereas interleukin-6 is related to abnormalities seen in acute liver injury. (HEPATOLOGY 1991;13:267—276).
Correction
Authors: L Roal, Medical Barclay, Town Burgess, Victoria Ial Mor, Stck Chilcren, Huill Chadwick, J Dally, M Hall, L Eng, C Tlond, E Dbwdney, Victoria Hospital, Sick Cuildren, Hull Filroo, W Watts, M Seng, L Fullard, M Eng, Hexham Unioln, Junior Resident, Mauchestec Loren's Hospital, Pendlebury Littleton, Philip Richard, Obstttric Malins, Antony Martin, D Lund, Seaside Diastrict, Unoin Moore, Ashion Iorris, C Glas, Vice George, Pier Swettenhax, Leminster Telling, Walter Maxwell, Plutrolc Dispensary, C Chadwick, M Enz
Journal: BMJ (1903)
Manuscripts Approved for JNCI, October-November 1972
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Manuscripts Approved for JNCI, October-November 1972 Get access JNCI: Journal of the National Cancer Institute, Volume 49, Issue 6, December 1972, Pages 1779–1781, https://doi.org/10.1093/jnci/49.6.1779-a Published: 01 December 1972
Protein synthesis in the developing rat liver: Participation of initiation factors eIF-2 and eIF-2B
Authors: A García
Journal: Hepatology (1994)

We studied the decline in protein synthesis in the developing liver in suckling rats (4 to 10 days) and adult rats (2 mo). The rate of protein synthesis was measured with a cell-free system and compared with the activity of two initiation factors, eukaryotic initiation factor-2 and eukaryotic initiation factor-2B, and with casein kinase II, which phosphorylates both factors in vitro. The specific activity of the three parameters decreased in adult rats compared with suckling rats and in parallel to the rate of protein synthesis. Quantification of eukaryotic initiation factor-2 in the ribosomal salt wash and in the postmicrosomal supernatant showed that both the specific activity and the levels of eukaryotic initiation factor-2, are much higher in the ribosomal salt wash fractions than in postmicrosomal supernatants, but no differences were found between the two age groups. The eukaryotic initiation factor-2/ribosome ratio was higher in adult rats than in suckling rats, and this parameter seems to be inversely proportional to the rate of protein synthesis. The phosphorylation state of eukaryotic initiation factor-2α, as determined by isoelectric focusing followed by protein immunoblotting, revealed very low and equal levels of phosphorylation in the two animal groups. The lack of changes in eukaryotic initiation factor-2 levels and phosphorylation status suggests that a decrease in the activity or levels of eukaryotic initiation factor-2B could be responsible for the decrease in eukaryotic initiation factor-2 activity and account for, at least in part, the differences observed in the rates of protein synthesis. (Hepatology 1994;20:706–713).
Lehrbuch der Röntgendiagnostik.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Choosing a psychotherapist
Authors: N. Schnaper
Journal: JAMA (1979)

THE PRACTICE of psychotherapy begs one and all to become practitioners of the art. The person (the consumer) who feels the need for help for emotional problems, where does he go and go with confidence? Selecting a competent physician involves many uncertainties; choosing a psychotherapist is a near impossibility. A surgeon may be judged by the neatness of the scar or the frequency of complications; the psychotherapist has no such measure. Anyone can play, and does. The question of how one chooses a therapist has plagued both helper and patient since the widespread acceptance of psychotherapy. The recent proliferation of modes of therapy and the folk culture surrounding approaches to emotional illness have compounded the difficulty. The proper approach to this problem is vital to the success of the ensuing endeavor, ie, the treatment itself. What follows is an attempt at a resolution or at least an understanding of the
ORANGE JUICE CONSIDERED IN A NEW LIGHT
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk factors for recurrent nonsyncopal falls. A prospective study
Authors: M. C. Nevitt
Journal: JAMA (1989)

Falls are a major threat to the health of older persons. We evaluated potential risk factors for falls in 325 community-dwelling persons aged 60 years or older who had fallen during the previous year, then followed up weekly for 1 year to ascertain nonsyncopal falls and their consequences. Risk factors for having a single fall were few and relatively weak, but multiple falls were more predictable. In multivariate analyses, we found increased odds of two or more falls for persons who had difficulty standing up from a chair, difficulty performing a tandem walk, arthritis, Parkinson's disease, three or more falls during the previous year, and a fall with injury during the previous year, and for whites. The proportion of subjects with two or more falls per year increased from 0.10 for those with none or one of these risk factors to 0.69 for those with four or more risk factors. Among older persons with a history of a recent fall, the risk of multiple nonsyncopal falls can be predicted from a few simple questions and examinations. (<i>JAMA</i>. 1989;261:2663-2668)
Klebsiella in the mucosal gut microbiota in primary sclerosing cholangitis is associated with more severe disease
Authors: Mikal Jacob Hole, Kristin Kaasen Jørgensen, Simen H. Hansen, Alexandra Götz, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov
Journal: Journal of Hepatology (2020)
Engel Unopposed?
Authors: CHASE PATTERSON KIMBALL
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 August 1972Engel Unopposed?CHASE PATTERSON KIMBALL, M.D.CHASE PATTERSON KIMBALL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-2-318_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: It is perhaps reductionistic to suggest that the current ferment over medical curriculum changes relates only to a crisis in health care and physician shortage (1, 2).Rather, much of the controversy addresses itself to other deficiencies prevalent in educational pedagogy and in the delivery of health services. Among these are the following:1. The method of teaching the basic sciences as they have been and are currently taught in most medical schools is often archaic. Many students enter medical school with better preparation in one third of these subjects than what the diluted and frequently ill-prepared...References1. ENGEL G: Must we precipitate a crisis in medical education to solve the crisis in health care? Ann Intern Med 76:487-490, 1972 LinkGoogle Scholar2. STETTEN D: Projected changes in medical school curriculum. Science 174:1303-1306, 1971 CrossrefMedlineGoogle Scholar3. WEED L: Medical records that guide and teach. N Engl J Med 278:593-599, 652-657, 1968 CrossrefMedlineGoogle Scholar4. KIMBALL C: The challenge of medicine in the seventies: health care through education. JAMA 216:2124-2127, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHASE PATTERSON KIMBALL, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1972Volume 77, Issue 2Page: 318-319KeywordsHealth careMedical services ePublished: 1 December 2008 Issue Published: 1 August 1972 PDF downloadLoading ...
Penetrating wounds of cardiac valves
Authors: J. W. Pate
Journal: JAMA (1969)

Penetrating injury to cardiac valves occurred in two patients. A patient with acute tricuspid insufficiency and conduction-bundle injury due to a gunshot wound had immediate valve replacement, pacemaker implantation, and excision of the lower lobe of the right lung with subsequent recovery. We believe this to be the first case of valve replacement for a gunshot wound successfully done at initial exploration. A patient had mitral insufficiency due to stab wound with eventual valve replacement. Early, definitive surgery with a heart-lung machine available is urged for all gunshot wounds and stab wounds suspected of causing major intracardiac damage.
Continuing Education Courses for Physicians
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of PCBs and Related Compounds on Hepatocarcinogenesis in Rats and Mice
Authors: Stuart Sleight
Journal: Environmental Health Perspectives (1985)

Commercial mixtures of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) can cause hepatocellular carcinoma in rats and mice. Present evidence indicates that these chemicals act as promoters and not initiators of hepatocarcinogenesis. Our results show that Firemaster BP-6 (FM) and its nontoxic major congener, 2,2', 4,4', 5,5'-hexabromobiphenyl (HBB), act as promoters in the two-stage model for hepatocarcinogenesis devised by Pitot and associates. A toxic congener, 3,3', 4,4', 5,5'-HBB, also was assessed for tumor-promoting activity. This congener, though not in FM, is similar to TCDD, in that both cause 3-methylcholanthrene (MC)-type induction of hepatic microsomal enzymes and produce similar toxic responses. FM contains several congeners which are mixed-type inducers in that they induce MC-type and phenobarbital (PB)-type enzymes. The toxicity of FM is most likely associated with its congeners which are mixed-type inducers and not to relatively nontoxic congeners such as 2,2', 4,4', 5,5'-HBB which are strictly PB-type inducers. Congener 3,3', 4,4', 5,5'-HBB acted as a tumor promoter only at a dose that was hepatotoxic. A synergistic effect on tumor promoting ability was produced by combining a nontoxic and nonpromoting dose of 3,3', 4,4', 5,5'-HBB with a promoting dose of 2,2', 4,4', 5,5'-HBB. Our results suggest that synergism between toxic and nontoxic congeners in FM may explain why mixtures such as FM have greater promoting ability than individual congeners. Our results also indicate that with PBB, toxicity and carcinogenicity are not necessarily related.
What Can the Study of Lead Teach Us about Other Toxicants?
Authors: Herbert L. Needleman
Journal: Environmental Health Perspectives (1990)

The history of knowledge about lead toxicity may serve as a useful template to judge and predict progress in understanding other toxicants. A paradigm shift has occurred in which toxicity has been recognized at levels long held to be harmless. This shift has been accelerated by the use of newer tools for measuring outcome. Lead effects have been identified in children at blood lead levels as low as 15 micrograms/dL. They include impaired psychometric intelligence, language function, attention, and classroom behavior. Lead exposure during pregnancy results in increased risk for minor malformations and lowered infant IQ scores until at least 2 years of age. Understanding of this toxicant has been blurred by seven unrecognized Type II errors frequently encountered in the lead literature. These errors are discussed. A meta-analysis of thirteen informative lead studies in children is presented. The joint probability of the findings occurring by chance under the null hypothesis is less than 3 x 10(-12).
Erratum: “Phthalates and Childhood Asthma: Revealing an Association through Urinary Biomarkers”
Journal: Environmental Health Perspectives (2013)

referred to plastic/polyvinyl chloride toys as "phthalate-rich" in a discussion of phthalate exposures among 10-year-old Norwegian children.The Consumer Product Safety Improvement Act of 2008 and European Commission Decision C(1999) 4436 of 7 December 1999 eliminated or suspended the use of certain phthalates of concern in toys and children's products.The children discussed in the News article were assessed in 2001-2004 and may have had access to toys purchased before the 1999 European ban.However, it was incorrect to suggest that all plastic toys continue to be "rich" sources of phthalates, and the article has been revised accordingly.EHP regrets the error.
Book Reviews
Authors: Ilkka T. Harvima, Heimo Viinamäki, Anita Naukkarinen, Kari Paukkonen, Heikki Neittaanmäki, Rauno J. Harvima, Maija Horsmanheimo, Denise M. Tope, Tim A. Ahles, Peter M. Silberfarb, Andrew B. Littman, M.G. Madianos, D. Madianou-Gefou, C.N. Stefanis, Michael W. Otto, Ronald A. Yeo, Brüt-Maj Wikström, Töres Theorell, Sven Sandström, Graeme J. Taylor, K.M. Bagby, J.D.A. Parker, Paul C. Horton, Herbert Gewirtz, Karole J. Kreutter, P. Bech, Jean Cottraux, Michael Bach, Doris Bach
Journal: Psychotherapy and Psychosomatics (1993)
CRLF2 over-Expression Is a Poor Prognostic Marker in Children with High Risk T-Cell Acute Lymphoblastic Leukemia
Authors: Chiara Palmi, Daniela Silvestri, Ilaria Bronzini, Gunnar Cario, Angela Savino, Maddalena Paganin, Barbara Buldini, Marta Galbiati, Martina U. Muckenthaler, Maurizio Arico, Elena Barisone, Fiorina Casale, Franco Locatelli, Luca Lo Nigro, Concetta Micalizzi, Rosanna Parasole, Andrea Pession, Maria Caterina Putti, Nicola Santoro, Anna Maria Testi, Ottavio Ziino, Andreas E Kulozik, Martin Zimmermann, Martin Schrappe, Giuseppe Basso, Andrea Biondi, Maria Grazia Valsecchi, Martin Stanulla, Valentino Conter, Geertruy te Kronnie, Giovanni Cazzaniga
Journal: Blood (2014)
Unconsciousness
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency Ambulance Dispatch: Is there a Case for Triage?
Authors: S Thakore, E A Mcgugan, W Morrison
Journal: Journal of the Royal Society of Medicine (2002)

Emergency telephone calls for an ambulance (999 calls) are usually dealt with first-come first-served. We have devised and assessed criteria that ambulance dispatch might use to prioritize responses. Data were collected retrospectively on consecutive patients presenting to an accident and emergency (A&E) department after a 999 call. An unblinded researcher abstracted data including age, date, time, caller, location, reason for call and A&E diagnosis and each case was examined for ten predetermined criteria necessitating an immediate ambulance response--namely, cardiac arrest; chest pain; shortness of breath; altered mental status/seizure; abdominal/loin pain >65 years old; fresh haematemesis; fall >2m; stabbing; major burns. 471 patients were recruited, 55% male, median age 50 years. 406 calls came from bystanders or the patients themselves, 36 from general practitioners, 8 from other hospitals and 21 from the police. 52% of patients were admitted. 44% met at least one of the above criteria. Most patients did not meet the criteria for an immediate ambulance response but might nonetheless be suitable for an urgent response. The criteria used in this study have the advantage of being based on the history provided by the caller. The introduction of a priority-based dispatch system could reduce response times to those who are seriously ill, and also improve road safety.
Src Homology 2 Domain-Containing Inositol-5-Phosphatase 1 (SHIP1) Negatively Regulates TLR4 Mediated LPS Signaling through Phosphatase Activity and PI3K Independent Mechanism.
Authors: Huazhang An, Hongmei Xu, Jun Zhou, Minghui Zhang, Xuetao Cao
Journal: Blood (2004)
Abstract 3692: The effect of endothelin 1 on cancer stem cell development
Authors: Akimasa Seno, Masaharu Seno
Journal: Cancer Research (2019)

Abstract Although we have been demonstrating the induction of cancer stem cells from ESCs or human/mouse iPSCs reprogrammed from normal fibroblasts using cancer cell conditioned media, the exact inducing factor is still unknown. Previously, we compared the gene expression profiles among hiPS/ESC, cancer stem like cells induced from hiPSC with cancer cell conditioned media, cancer stem cells obtained from cancer tissue or cell culture, and cancer cells. In this study, the expression of endothelin 1 was found commonly upregulated in different cancer stem cell groups. To investigate the roles of endothelin 1 in the development of cancer stem cells, the significance of endothelin 1 signaling including endothelin 1 in the cancer cell conditioned media and the expression of endothelin 1 receptors in iPSCs as well as in the developed cancer stem cells were quantitatively and qualitatively evaluated. Citation Format: Akimasa Seno, Masaharu Seno. The effect of endothelin 1 on cancer stem cell development [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3692.