tbuckley/cabot-search huggingface dataset:
Mesenteric Lipodystrophy
Authors: ROBERT E. KIPFER
Journal: Annals of Internal Medicine (1974)

The clinical presentation of 53 patients with mesenteric lipodystrophy was variable and nonspecific. Most characteristic was a left upper-quadrant abdominal mass in an older person with either no symptoms or vague abdominal distress. Laboratory and roentgenologic findings were not helpful, and diagnosis was made by laparotomy. At surgery the disease presented as diffuse mesenteric thickening (42%), a single discrete tumor (32%), or multiple tumors (26%). Microscopically, there were altered lipocytes and fat-laden macrophages with little inflammatory reaction or fibrosis, suggesting a degenerative process of the fat rather than a true panniculitis. The course of the untreated disease was usually benign. The commonest outcome was spontaneous relief of symptoms; in some patients the disease had completely disappeared at subsequent abdominal operation. No treatment was of proved benefit. Eight patients (15%) also were found to have malignant lymphomas. The nature of this association remains unexplained.
Drug treatment of psychiatric patients in general practice.
Authors: S Shalet, C Beardwell, P H Morris Jones, Dorothy Pearson
Journal: BMJ (1978)

In addition, a recent study4 of testicular morphology in boys treated for acute lymphoblastic leukaemia (ALL) with combination chemotherapy found no evidence of a relation- ship between the degree of tubular damage and the age at which the subject first received cytotoxic therapy.Therefore the prepubertal testis would appear to be just as vulnerable to cytotoxic damage as the pubertal testis.Finally, it is true that we observed5 depressed ovarian function in a proportion of girls previously treated for ALL with combination chemotherapy.However, the evidence indi- cated direct damage to the ovaries due to the chemotherapy rather than as a consequence of radiation-induced hypothalamic-pituitary damage.
Guanidine in botulism
Authors: S. B. Werner
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The article by Eason et al (240:670, 1978) describes the usefulness of alkalinization of the urine in the dissolution of uric acid stones. The efficacy of this treatment is now well documented. The difficulty is, as noted by Eason and colleagues, when the patient has obstruction of the collecting system. Retrograde catheterization has been used in such patients, and those references were quoted by the authors. An alternative approach is available for the obstructed patient with uric acid lithiasis. This involves the use of percutaneous nephrostomy for urinary diversion associated with the conservative medical treatment already well described. We have published an article describing this technique and the results in two patients,<sup>1</sup>which appeared after the article by Eason and co-authors. The use of percutaneous nephrostomy has increased as its safety and efficacy have been proved.<sup>2</sup>A two-catheter technique can also be used with percutaneous
The deluge of unsubscribed medical oncology information
Authors: D. M. Mintzer, L. Chmielewski
Journal: Journal of Clinical Oncology (2005)

6106 Background: The volume of unsubscribed, unsolicited medical oncology information being distributed to oncologists is rapidly increasing. We assessed this increasing influx of information in regards to volume, medium, sponsorship and peer review and compared it to the volume of subscribed/requested medical information. Methods: All mail, faxes and emails sent to this oncologist (DMM) in a single month (July 2004) were collected, reviewed, and compared to the volume of the standard journals to which we subscribed. Results: During one month, we received 205 separate unsolicited communications. The material measured 12“ high and weighed 14#s. It included 10 peer reviewed journals (640 pages), 7 newspapers (621 pages), 18 non-peer reviewed publications such as monographs, case reports and symposia proceedings (261 pages), 12 audio CDs/DVDs, 23 emails, and 55 invitations to medical meetings. Nearly all of this material was sponsored either directly or indirectly by the pharmaceutical industry. This volume of material was approximately 20 times the pages of subscribed medical information (which included eg, JCO, NEJM, AIM, Blood). Conclusions: Oncologists are inundated with medical info from the pharmaceutical industry, with its potential bias, that can overwhelm standard peer-reviewed, requested journals by many fold. While much of this info is useful, well written by experts, and peer-reviewed, it seems that the separation between classical peer-reviewed materials and advertising/marketing is no longer distinct, but rather appears to be an intentionally blurred, seamless continuum. Oncologists need to be cautious in assessing the source and objectivity of this overwhelming influx of information and in preventing it from distracting them from classical peer-reviewed literature. No significant financial relationships to disclose.
Endobronchial metastasis of uterine leiomyosarcoma
Authors: K. J. Flynn
Journal: JAMA (1978)

A STRIKINGLY large endobronchial metastasis of a uterine leiomyosarcoma developed in a woman. It is reported because of its size and location and because report of such a lesion, to our knowledge, is not found in studies of endobronchial metastases. <h3>Report of a Case</h3> A 53-year-old, gravida 10, para 8, abortus 2, woman underwent total abdominal hysterectomy and bilateral salpingooophorectomy in August 1973. The uterus was found to contain an 8.5×6.0×5.0-cm firm, well-circumscribed, whitish mass that had the histological characteristics of leiomyosarcoma. There was no evidence of metastatic disease. She did well until April 1977, when she had sudden onset of dyspnea and wheezing. A chest roentgenogram showed leftsided "white lung," with right upper lobe and right basilar infiltrates (Figure). Physical examination showed an obese, distressed woman with prolonged expirations and loud expiratory wheezing. The hemoglobin value was 13.2 g/dl, the hematocrit level was 44%, and the WBC count was
Le traitement de la syphilis par les composés arsenicaux et les préparations bismuthiques avec l'exposé des nouvelles méthodes de laboratoire.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adenoma Arising in Struma Ovarii
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Betamethasone 17-Valerate and Prednisolone 21-Phosphate Retention Enemata in Proctocolitis: A MULTICENTRE TRIAL
Authors: St Mark's Hospital, J Jones, J Lennard- Jones, J Misiewicz, ', J Parrish, : Atkinson, A London, A Otaki, W Sircus, R Walker, G Watkinson
Journal: BMJ (1971)

The efficacy of betamethasone 17-valerate (5 mg) and prednisolone 21-phosphate (20 mg) retention enemata in the outpatient treatment of distal proctocolitis was compared in a formal clinical trial. The two treatments were equally effective in inducing remissions of the disease, but the betamethasone valerate enema produced less adrenal suppression.
Ethinyl estradiol and conjugated estrogens as postcoital contraceptives
Authors: G. W. Dixon
Journal: JAMA (1980)

Five study centers enrolled 1,311 women seeking postcoital contraception methods. Ethinyl estradiol was administered at 5 mg/day and conjugated estrogens at 30 mg/day for five consecutive days starting within 72 hours of unprotected coitus. Eleven pregnancies occurred in the 976 women who had a single unprotected coitus at midcycle. Based on published information, 69 pregnancies would have been expected if no contraceptives were used. Although both treatments were effective in preventing pregnancy, ethinyl estradiol seemed to be more effective. At the two centers alternately prescribing both drugs, none of 137 women treated with ethinyl estradiol became pregnant, while six of the 132 given conjugated estrogens became pregnant. Women whose treatment commenced on the first postcoital day seemed to have lower pregnancy rates than those whose medication was delayed to the second or third postcoital day regardless of which drug was used. Side effects were mainly limited to nausea that occurred in 70% and vomiting that was experienced by 33% of all women treated. (<i>JAMA</i>244:1336-1339, 1980)
Short Cuts
Journal: BMJ (2005)

ConclusionBlood pressure can be controlled to the same degree with either practice based self monitoring or usual care.Self monitoring of blood pressure results in worthwhile improvements in systolic blood pressure at six months.How this early improvement might be maintained requires further study.Self monitoring has negligible costs, reduces practice consulting rates, and is acceptable to patients.If the training associated with self monitoring were performed by non-medical or lay individuals then cost savings might be possible.
Mesenchymal Stromal Cells Orchestrate Follicular Lymphoma Cell Niche Through the CCL2-Dependent Recruitment and Polarization of Monocytes
Authors: Fabien Guilloton, Gersende Caron, Cédric Ménard, Céline Pangault, Patricia Amé-Thomas, Joelle Dulong, John De Vos, Delphine Rossille, Thierry Lamy, Thierry Fest, Karin Tarte
Journal: Blood (2011)
Colon Polyps and Cancer
Authors: J. H. Bond
Journal: Endoscopy (1999)

A number of recent publications dealing with colon polyps and cancer emphasize cost-effectiveness and the outcomes of screening and follow-up surveillance of high-risk groups. These groups include patients with either a past personal history or a family history of colorectal adenomas or cancer. Several papers address the effectiveness and compliance with different methods of screening of the asymptomatic, average-risk population for colorectal neoplasia. Other important publications deal with colorectal cancer prevention, the natural history of the adenoma-carcinoma sequence, diagnosis of polyps and cancer, colonoscopic polypectomy, management of the patient with a malignant polyp, and endoscopic treatment of obstructing cancer.
Tina Chan
Journal: BMJ (2005)

Psychiatrist who reinterpreted the Royal Free fatigue epidemic and wrote historical atlases Colin McEvedy was interested in mass movements of people, whether as a psychiatrist, historian, or demographer, but it was his analysis of a mystery illness at the Royal Free Hospital in London that made his name in psychiatry.In 1955 an epidemic swept through the nursing staff at the Royal Free, closing the hospital for three months.In all, 300 people were affected, 200 of whom were admitted.No one died and not one single hospital patient was affected, and no causative organism was ever found, though not for want of looking.The disease was described as a benign, myalgic form of encephalomyelitis.Fifteen years later, Colin McEvedy, then a senior registrar at the Middlesex Hospital, co-wrote two papers (with his boss, Professor Bill Beard), arguing, firstly, that the epidemic was one of conversion hysteria triggered by fear, probably of polio (BMJ 1970;1(687):7-11), which was still a serious problem at the time; and, secondly, that it was one of several reported similar epidemics, others of which were among hospital nurses (BMJ 1970;1(687):11-15).McEvedy was meanwhile writing a thesis on two epidemics of mass hysteria in girls' schools.His doctoral thesis was accepted without difficulty, but the papers on the Royal Free outbreak were greeted with howls of rage.Although he and Beard emphasised that the diagnosis of hysteria was "not a slur on the individuals or the institution involved" and that "the hysterical reaction is part of everyone's potential," many people, it seemed, felt that while hysteria was an acceptable diagnosis in the case of schoolgirls, it was not in the case of nurses.McEvedy and Beard's argument was that, in addition to the absence of an identifiable causative organism, most people recovered unremarkably, and most biochemical tests were normal.Most sufferers had depression, fatigue, and vague neurological signs.Many had paralysis or sensory disturbances, but their reflexes were normal.Taking the institution as a wholestaff, students, and patients-the epidemic affected 10.4% of women and only 2.8% of men.Two sufferers who died from other causes (ovarian cancer, disseminated
The Role of Toxicological Interactions in Lung Injury
Authors: H. P. Witschi, P. J. Hakkinen
Journal: Environmental Health Perspectives (1984)

Interactions between two or more toxic agents can produce lung damage by chemical-chemical interactions, chemical-receptor interactions or by modification, by a first agent, of the cell and tissue response to a second agent. Interactions may occur by simultaneous exposure and if exposure to the two agents is separated in time. Chemical-chemical interactions have been mostly studied in the toxicology of air pollutants, where it was shown that the untoward effect of certain oxidants may be enhanced in the presence of other aerosols. Interactions at the receptor site have been found in isolated perfused lung experiments. Oxygen tolerance may be an example, when pre-exposure to one concentration of oxygen mitigates later exposure to 100% oxygen by modifying cellular and enzymatic composition of the lung. Damage of the alveolar zone by the antioxidant butylated hydroxytoluene (BHT) can be greatly enhanced by subsequent exposure to oxygen concentration which, otherwise, would have little if any demonstrable effect. The synergistic interaction between BHT and oxygen results in a resulting interstitial pulmonary fibrosis. Acute or chronic lung disease may then be caused not only by one agent, but very likely in many instances by the interaction of several agents.
Professional football player suspensions re-emphasize problems of steroid abuse
Authors: V. S. Cowart
Journal: JAMA (1989)

WITH THE 30-DAY suspensions of 13 players in the National Football League (NFL) who had positive tests for anabolic steroids coming to an end, an examination of their impact is timely. (There were 24 positive steroid tests, but 11 players had already been cut by various teams before the results were announced.) Don Weiss, executive director of the NFL, hopes the message to professional football players will be that the use of anabolic steroids will not be condoned by the league. This is the third year that players have been tested for steroids, but the first time any penalty was attached to their use. Only one preseason drug test of professional football players is allowed under the contract with the NFL Players Association and that test is done at the beginning of training camp. <h3>Facing Further Testing</h3> However, there is a provision for "reasonable cause" testing. The 13 players who
The Clinical Interpretation of Blood Chemistry.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Budget
Authors: Mike Mitka
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PDTM-01. GERMLINE GENETIC PREDISPOSITION TO PEDIATRIC GLIOMA
Authors: Ivo Muskens, Kyle Walsh, Adam de Smith, Libby Morimoto, Catherin Metayer, Xiaomei Ma, Joseph Wiemels
Journal: Neuro-Oncology (2018)

Pediatric gliomas constitute a majority of pediatric brain tumors and intermediate to high grade gliomas have high mortality. While some advances have been made over recent years with regards to pediatric glioma etiology, genetic predisposition has not been investigated thoroughly. In this study, the role of rare germline variants on risk of pediatric glioma was evaluated in 322 astrocytoma patients (predominantly grade II and III) using whole-exome sequencing and detailed evaluation of 162 known cancer-related genes. DNA samples were extracted from neonatal dried bloodspots from 322 pediatric glioma patients born and diagnosed in California, and sequenced using the Personalis ACE whole-exome sequencing platform. Exome alignment and variant calling was performed using Samtools and GATK 3.8. SnpEff and Combined Annotation Dependent Depletion (CADD) tools were used for variant annotation. Only variants that were not present in the 1000 Genomes dataset, had allele frequency smaller than 0.01% in the Exome Aggregation Consortium (ExAC) database, a CADD score greater than 20, and a moderate or high variant effect impact were included to identify rare putatively deleterious variants. All samples passed quality control and the mean read depth was 41.4. Seventy-one (22.0%) samples harbored a mutation that was potentially deleterious in at least one of the 162 cancer-related genes. The most commonly affected gene encodes a specific receptor tyrosine kinase (RTK) (28 patients, 8.7%), followed by a DNA polymerase enzyme(5 patients), and a specific mismatch repair protein(5 patients). Alterations of the tyrosine kinase protein may impact cell growth, mutation, and maturation of nerve cells. This study supports a role for rare germline mutations in the etiology of pediatric glioma and implicates RTK biology in glioma predisposition. These findings have translational implications for risk prediction and targeted therapy.
Effects of Sulfite on the Uptake and Binding of Benzo[a]pyrene Diol Epoxide in Cultured Murine Respiratory Epithelial Cells
Authors: Justin L. Green, Brian C. Jones, Gregory A. Reed
Journal: Environmental Health Perspectives (1994)

Sulfur dioxide (SO2) may act as a cocarcinogen with benzo[a]pyrene (BaP) in the respiratory tract. We have modeled this effect by examining the interactions of 7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) with sulfite, the physiological form of SO2, in a murine respiratory epithelial cell line (C10). We exposed C10 cells to [3H]-anti-BPDE and determined the effects of 1 and 10 mM sulfite on the uptake and subcellular localization of labeled products. Autoradiographic analysis showed that sulfite doubled the nuclear localization of anti-BPDE-derived materials after a 4-hr incubation period. The net nuclear localization of anti-BPDE-derived materials was not affected by sulfite during the first 60 min, but nuclear localization continued to increase in the sulfite-containing incubations throughout the 4-hr incubation period. Little increase in nuclear localization of anti-BPDE-derived material was noted in the incubations without sulfite after 60 min. Subcellular fractionation was performed to determine the amount of label associated with cytosolic and nuclear fractions and to determine covalent binding to protein and DNA. Sulfite produced a modest increase in the amount of [3H]-anti-BPDE-derived products bound to protein; however, binding to nuclear DNA increased by more than 200% with 10 mM sulfite. Analysis of the supernatants from the cytosolic and nuclear fractions of cells exposed to anti-BPDE and sulfite demonstrated the presence of 7r,8t,9t-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene-10c-su lfonate (BPT-10-sulfonate). [3H]-BPT-10-sulfonate was unable to enter C10 cells, suggesting that it is formed intracellularly.(ABSTRACT TRUNCATED AT 250 WORDS)