tbuckley/cabot-search huggingface dataset:
Abstract 12432: Temporal Trends over a Decade of Defibrillator Therapy for Primary Prevention in Community Practice
Authors: Eloi Marijon, Rui Providência, Abdeslam Bouzeman, Vincent Algalarrondo, Kumar Narayanan, Pascal Defaye, Nicolas Sadoul, Olivier Piot, Didier Klug, Daniel Gras, Laurent Fauchier, Pierre Bordachar, Dominique Babuty, Jean-Claude Deharo, Christophe Leclercq, Serge Boveda
Journal: Circulation (2015)

Aims: Technology and clinical practice surrounding the use of the primary prevention implantable cardioverter defibrillator (ICD) are in a state of constant evolution. Using a multicenter national registry, we evaluated temporal trends in characteristics and outcomes over a decade of ICD therapy. Methods and Results: Between 2002-2012, 5,539 consecutive patients (age 62.5±11 years, 84.9% male, 60.2% with coronary artery disease) implanted with a primary prevention ICD from 12 centers in France were enrolled. Information on characteristics and outcomes (including causes of death) were evaluated over a median follow-up of 994 days [466-1,667]. In addition to a shift in the type of devices implanted with a significant increase in cardiac resynchronization therapy-defibrillator (CRT-D) over time (43.6 to 60.4%, P=0.0001), an increase in mean age (from 61.5±11.6 to 63.2±10.9 years, P=0.0016), proportion of non-ischemic cardiomyopathy (31.0 to 44.7%, P&lt;0.0001) and women recipients (11.4 to 15.8%, P=0.004) was observed. A total of 1,181 patients (22.3%) received ≥1 appropriate therapy, inappropriate therapies occurred in 355 patients (6.7%) and 826 patients (15.2%) died mainly from cardiovascular cause (407 patients corresponding to 49.3%). Annual mortality incidence (5.4 to 4.3%, P=0.05) and annual incidence of appropriate therapy (10.4 to 7.1%, P=0.0004, Figure) significantly decreased over the decade. By contrast, incidences of ICD-related complications increased over the decade (4.6 to 7.6%, P=0.003). Conclusion: Our findings demonstrate significant changes in patterns of use and outcomes in primary prevention ICD over the last decade with reductions in mortality, appropriate therapies, associated with an increase in complications.
ABSORPTION IN INTESTINAL OBSTRUCTION
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Author Index
Authors: Giovanni A. Fava, Barrie R. Cassileth, Douglas A. Drossman, Howard Berenbaum, E.H. Friedman, Paul M.G. Emmelkamp, Patricia van Oppen, Bernhard Strauss, Manuela Burgmeier-Lohse, Gereon Heuft, Wolfgang Senf, T. Platz, B. Junkert, W. Tress, H. Schepank, F. Anagnostopoulos, Gr. Vaslamatzis, M. Markidis, Kl. Katsouyanni, St. Vassilaros, C. Stefanis, Wolfgang Wöller, Johannes Kruse, Petra Winter, Elmar J. Mans, Luciano Alberti, James D.A. Parker, Graeme J. Taylor, Michael Bagby, Douglas E. Webb, Jr., Joen Fagan, George M. Simpson
Journal: Psychotherapy and Psychosomatics (1993)
Gout
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiple Lobotomies
Authors: WALTER FREEMAN
Journal: American Journal of Psychiatry (1967)

Data on a group of 414 patients who underwent multiple lobotomies and were followed over an average period of 12.4 years from the first operation confirm the belief that such operations are worthwhile in patients who relapse after the first lobotomy The orbitomedial quadrants are the most promising site of operation in patients with affective, psychoneurotic, and early schizophrenic disorders, while an additional incision into the frontotemporal connections benefits those who are disturbed by hallucinations.
A10.11 Non-canonical nf-κb signalling in microvessels of atherosclerotic lesions in coronary arteries is associated with inflammatory cell infiltration and myocardial infarction
Authors: CX Maracle, R Agca, B Helder, HWM Niessen, M Nurmohamed, SW Tas
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background&nbsp;and&nbsp;objective</h3> Patients with chronic inflammatory diseases (CID) have higher risk of developing cardiovascular disease which may be in part due to increased systemic inflammatory burden. In atherosclerosis, extensive neovascularization is associated with plaque instability and increased chance of myocardial infarction (MI). We have established that non-canonical NF-κB signalling, and its central regulator NF-κB inducing kinase (NIK) in endothelial cells (EC) contributes to angiogenesis in synovial tissue of patients with various types of arthritis. Thus, we hypothesised that NIK<sup>+</sup> EC may also contribute to neovascularization in atherosclerotic lesions. <h3>Methods</h3> Atherosclerotic lesions from 11 individuals with CID and 11 matched controls, isolated from parts of the coronary artery implicated in MI (CA+) or not (CA-), were immunohistochemically stained with antibodies against NIK, CD31/34 (EC), myeloperoxidase (neutrophils), CD45 (lymphocytes), CD68 (macrophages) and tryptase (mast cells). NIK vessel density (NIK<sup>+</sup>VD) and immune cell density (ICD) were subsequently calculated. <h3>Results</h3> NIK<sup>+</sup>EC were present in atherosclerotic lesions of all coronary arteries. NIK<sup>+</sup>VD significantly correlated with ICD of all characterised immune cells: leukocytes (r = 0.5227; p &lt; 0.0001), macrophages (r = 0.3397, p &lt; 0.0001), mast cells (r = 0.4205, p &lt; 0.0001) and neutrophils (r = 0.2129, p = 0.0016). No significant differences were found in NIK<sup>+</sup>VD in CID patients versus healthy, however, influx of leukocytes and macrophages per NIK<sup>+</sup> microvessel was significantly higher in CID lesions. Increased NIK<sup>+</sup> microvessels were also noted in CA+ as compared to CA- tissues (p = 0.0139) in both healthy and CID patients. <h3>Conclusions</h3> NIK<sup>+</sup> microvesselsare present inhigh numbers in atherosclerotic lesions&nbsp;and are strongly associated with the influx of inflammatory cells. Systemic inflammation is not a prerequisite for activation of this pathway in EC in atherosclerotic lesions, but our findings suggest that non-canonical NF-κB signalling is more pronounced in patients with CID resulting in the attraction of more immune cells that may further enhance progression of atherosclerotic lesions. Since activation of the non-canonical NF-κB pathway in EC induces angiogenesis and NIK<sup>+</sup> vessels are increased in coronary arteries associated with MI, non-canonical NF-κB signalling in EC may drive neovascularization and plaque instability, thus increasing the chance of developing a (fatal) MI.
Abstract 2008: CENP-E kinesin facilitates chemokine ligand CCL18 translocation to promote migration in triple negative breast cancer
Authors: McKay M. Mullen
Journal: Cancer Research (2019)

Abstract Our research is focused on the molecular mechanisms responsible for enhanced cellular proliferation and migration as it relates to triple negative breast cancer (TNBC). Advances in visualization techniques and technologies work to provide an in-depth view of various cellular mechanisms, allowing us to capture molecular level protein-protein interactions previously unknown. There are more than 40 kinesin motor proteins found within the spindle assembly checkpoint, classified into 14 families, which each play essential roles in microtubule-dependent intracellular trafficking. This assembly is a critical component to the cell cycle control complex that acts during mitosis to prevent chromosome missegregation and aneuploidy. Centromere associated protein E (CENP-E) is a kinesin motor protein that shows aberrant overexpression in TNBC which facilitates exponential cell growth and eventual metastasis that occurs in TNBC. Growing awareness through scientific discoveries sheds light on the fact that it is a rare occurrence for biological functions to be attributed to a single mutated macromolecule. Most physiological processes arise from a complex orchestration of cellular events occurring between multiple molecules acting in concert. The nature of protein-protein transactions that drive gene activation appear to be dynamic in TNBC cells thus enabling uncontrolled proliferation. We believe that a pleiotropic network of small molecules may be working cooperatively with CENP-E to facilitate the exponential cell growth and eventual metastasis that occurs in TNBC cells. Currently, we are carrying out spectral imaging and biophysical force measurements to delineate CCL18-elicited cell mechanics and breast cancer metastasis. To address this, we have incorporated syntelin, a small inhibitory molecule targeted to CENP-E in an effort to analyze the resultant effect it has on this network of proteins we believe may be involved in the CENP-E signaling cascade. Taken together, these results indicate that syntelin may comprise a novel targeted chemotherapeutic intervention for TNBC. Citation Format: McKay M. Mullen. CENP-E kinesin facilitates chemokine ligand CCL18 translocation to promote migration in triple negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2008.
Relationships Between Retinal Axonal and Neuronal Measures and Global Central Nervous System Pathology in Multiple Sclerosis
Authors: Shiv Saidha, Elias S. Sotirchos, Jiwon Oh, Stephanie B. Syc, Michaela A. Seigo, Navid Shiee, Chistopher Eckstein, Mary K. Durbin, Jonathan D. Oakley, Scott A. Meyer, Teresa C. Frohman, Scott Newsome, John N. Ratchford, Laura J. Balcer, Dzung L. Pham, Ciprian M. Crainiceanu, Elliot M. Frohman, Daniel S. Reich, Peter A. Calabresi
Journal: JAMA Neurology (2012)
The English hepatitis C registry shows only a modest effect from non-completion of directly-acting antivirals for hepatitis C: SVR rates over 80% in genotype 1, 2 or 3 HCV if more than one third of planned treatment is completed
Authors: Kate Drysdale, Yevedzo Ntuli, Jonathan Bestwick, Ceri Townley, Faizel Mahomed, Graham Foster
Journal: Journal of Hepatology (2020)
Atrial fibrillation
Authors: K. E Griffith, M. Pye
Journal: BMJ (2008)

A 63 year old man sees your practice nurse for a routine blood pressure check. He has had hypertension for five years and is taking ramipril 10 mg, bendroflumethiazide 2.5 mg, and atenolol 25 mg daily. He has no past history of ischaemic heart disease, stroke, or diabetes. The nurse’s electronic sphygmomanometer is unable to produce a recording, and she asks for your advice. You find his pulse to be intermittently irregular.
A test for transplantability of animal hearts
Authors: J. T. Apter
Journal: JAMA (1968)

Current studies in transplantation of canine and human hearts have made it advisable to develop a method for detecting postmortem changes in hearts quickly and accurately. We use reversibility of the thermal responses of the viscoelastic properties of cardiac muscle to determine whether or not an excised heart is in a steady state. The test samples are taken from the tip of the atrial appendage and a report of cardiac muscle status may be made within 15 minutes, or before chemical signs of rigor mortis appear in the sampled organ. <h3>Methods Used in Designing the Test.—</h3> Rectangular segments of ventricles, atria, and atrial appendages were excised from in situ hearts of 17 dogs, 23 cats, and 13 rabbits anesthetized with 30 mg/kg of body weight of sodium pentobarbital. With this technique, a slit in the segment is slipped over two hooks to support it horizontally in a bath of known
Selected Articles from This Issue
Journal: Clinical Cancer Research (2021)

Donor T cell costimulation and IL-6 cytokine activation mediate acute graft-versus-host disease (GVHD) via mTOR and JAK2 signaling pathways, respectively. In this first-in-human phase I trial, Pidala and colleagues show that the JAK2 inhibitor, pacritinib, plus sirolimus and low-dose tacrolimus (PAC/SIR/TAC) is safe and demonstrates preliminary efficacy in GVHD prevention after allogenic hematopoietic cell transplantation. PAC/SIR/TAC ablates aberrant JAK2 and mTOR activity in donor T cells, polarizes regulatory T-cell responses, and avoids cytopenia observed with pan JAK inhibitors. PAC/SIR/TAC is a promising GVHD prophylaxis regimen to achieve immune tolerance while maintaining anti-leukemia responses from NK cells and cytotoxic T lymphocytes.BAY1436032 is an inhibitor of mIDH1 that increases survival and induces markers of differentiation in animal models of mIDH1 glioma. Wick and colleagues describe the results of a first-in-human phase I clinical study of BAY1436032 in subjects with solid tumors. BAY1436032 was well-tolerated, demonstrated target inhibition, and showed evidence of clinical activity including durable objective responses in a small subset of heavily pretreated subjects with mIDH1 lower-grade glioma. These findings support the continued clinical evaluation of mIDH1 inhibitors in this patient population and indicate that some mIDH1 solid tumors may be susceptible to differentiation therapy.ATRT-MYC, ATRT-SHH, and ATRT-TYR are three molecular group. of atypical teratoid rhabdoid tumor (ATRT). However, the relationship between molecular group and outcome has not been studied prospectively. In this study, Upadhyaya and colleagues utilized two prospective multi-institutional clinical trials to assess the contribution of molecular group to outcome in children with newly diagnosed ATRT. Infants with ATRT-TYR tumors were likely to have localized disease and improved prognosis, while children with ATRT-SHH tumors were more likely to have metastatic disease and poor outcome. Germline mutations in SMARCB1 were associated with metastatic disease, but not progression-free survival. These results support the use of molecular grouping in future trials of children with ATRT.Total neoadjuvant therapy (TNT) is currently used for patients with locally advanced rectal cancer (LARC) and is often followed by a watch-and-wait approach. However, many patients will develop metastasis and succumb to their disease. Vidal and colleagues assess the role of circulating tumor (ct) DNA before rectal surgery to predict response to TNT, relapse, and survival in LARC patients in the GEMCAD 1402 trial. Using an ultrasensitive ctDNA assay, detectable presurgery ctDNA was significantly associated with systemic recurrence, shorter disease-free survival, and shorter overall survival. The authors propose future clinical trials using ctDNA to personalize treatment for patients with LARC.
Loss of maternal allele in a child with myelodysplastic syndrome and monosomy 7
Authors: Dilek Aktas, Idıl Yenicesu, Gonul Hıcsonmez, Ergul Tuncbilek
Journal: American Journal of Hematology (1999)

Monosomy 7 or partial deletion of the long arm of chromosome 7 is frequently described in children with myelodysplastic syndrome and acute myeloblastic leukemia. Parental origin of chromosome 7 in children with sporadic monosomy 7 has been examined very rarely. To investigate if monosomy 7 shows parent-of-origin, we have studied a female child with monosomy 7 and de novo myelodysplastic syndrome by a series of polymorphic polymerase chain reaction markers. We found loss of maternal allele and discussed the results with the previous reports. Am. J. Hematol. 62:49–51, 1999. © 1999 Wiley-Liss, Inc.
FDA Approval of a Fourth Acellular Pertussis Vaccine for Use Among Infants and Young Children
Journal: JAMA (1999)

On July 29, 1998, the Food and Drug Administration (FDA) licensed North American Vaccine, Inc. (Beltsville, Maryland) to distribute a combined diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP) (Certiva) for the first four doses of the diphtheria and tetanus toxoids and pertussis vaccination series administered to infants and children aged 6 weeks-6 years. Certiva is the fourth acellular pertussis vaccine to be licensed for use in infants and young children in the United States.
Editorial Board
Authors: Stavroula Kousta, Katja Brose, Rolf Van Der Sanden, Loek De Weerd, R Adolphs, R Baillargeon, D Chalmers, N Chater, J Cohen, J Driver, A Engel, R French, A Friederici, M Goodale, M Hauser, R Jackendoff, P Johnson-Laird, S Kosslyn, N Logothetis, J Mcclelland, L Nadel, S Pinker, Z Pylyshyn, T Robbins, S Shamma, A Wagner, V Walsh, D Wolpert, Anthony Dick, Uri Hasson, Jonathan St, David Evans, Ruth Over, Philip Byrne
Journal: Trends in Cognitive Sciences (2009)
HIGH PROTEIN DIET AND RENAL IRRITATION
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentary
Authors: Peter D. Siersema
Journal: Endoscopy (2020)

Variceal bleeding is a serious complication of liver cirrhosis; it occurs in one third of patients with varices and is refractory in 10 % – 20 % of patients. Endoscopic band ligation is the initial treatment for bleeding esophageal varices. Nonetheless, some varices are refractory or recur within 6 – 12 hours.
Coding Error in Analysis of Rotavirus Vaccination and Type 1 Diabetes
Authors: Kirsten Perrett, Kim Jachno, Terry Nolan, Murdoch Chil
Journal: JAMA Pediatrics (2019)

Kirsten P. Perrett, MBBS, FRACP, PhD; Kim Jachno, BSc, MBiostat; Terry M. Nolan, MBBS, PhD, FRACP, FAFPHM, FAHMS; Leonard C. Harrison, MBBS, MD, DSc, FRACP, FRCPA, FAHMS
Quality-of-life in patients with metastatic colorectal cancer (mCRC) treated with aflibercept and FOLFIRI – Interim results of the non-interventional AIO study QoLiTrap
Authors: R. von Moos, G. Derigs, F. Scholten, J. Thaler, C. Losem, H. Kroening, C. Windemuth-Kieselbach, R.D. Hofheinz
Journal: Annals of Oncology (2017)
Tay-Sachs Genotypes
Journal: BMJ (1971)

Queen Charlotte's Hospital The Department of Health announced last week that the present Queen Charlotte's Hospital and the Chelsea Hospital for Wo- men will eventually be rebuilt as part of the new King Edward Memorial Hospital which is being developed on the site of St. Bernard's Hospital, Ealing.Queen Char- lotte's name and functions will be preserved at the new site, which, says the Department, is well placed to serve the area from which Queen Charlotte's is increasingly drawing its patients.The new unit will provide the obstetrical and gynaecological services of the new district general hospital, and Queen Charlotte's links with postgraduate medical education through its associat-on with the Institute of Obstetrics and Gynaecology will continue after the move to Ealing.Discussions will start soon between Sir Keith Joseph and the board of governors, the other hospital authorities concerned
Depression, violent suicide tied to low metabolite level
Authors: T. Ziporyn
Journal: JAMA (1983)

Starting in the 1960s, investigators began to note several biologic characteristics associated with suicidal behavior: high excretion of 17-hydroxycorticosteroids in urine, low monoamine oxidase (MAO) activity in blood platelets, blunted thyroid stimulating hormone response to thyroid releasing hormone and, finally, low levels of a dopamine metabolite, homovanillic acid (HVA), and of a serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF). Because low 5-HIAA levels were reported also in depressives and because patients are often both suicidal and depressed, more recent research has focused on the link between low 5-HIAA levels, depression, and suicidal behavior. At this year's Seventh World Congress of Psychiatry in Vienna, the nature of this link further unfolded. Eugene S. Paykel, MD, FRCP, FRCPsych, reported that major depression seems to precede "a moderately high proportion of [actual] suicides but a much lower proportion of attempted suicides." The latter behavior probably characterizes a distinct group, added
Antiepileptic drugs, the developing nervous system, and the pregnant woman with epilepsy
Authors: K. F. Swaiman
Journal: JAMA (1980)

There have been a number of reports of the teratogenic effects of phenytoin sodium and other antiepileptic drugs on the fetus (p 1464), but scant attention has been given to the possible effects on the developing nervous system. Numerous reports of developmental delay associated with teratogenic effects in both humans and animals exposed to antiepileptic drugs, particularly trimethadione, suggest that the CNS is also adversely affected. The information available is inconclusive; nevertheless, it is a mistake to ignore the continuing clinical and experimental reports of deleterious effects. There are insufficient data available to guide the physician to permit a choice among anticonvulsant drugs for the treatment of pregnant epileptic women, based not only on efficacy but also on safety. The evaluation of the effects of antiepileptic drugs on normal growth and development of nervous tissue is a difficult but necessary task. More research is needed to evaluate the relative safety