tbuckley/cabot-search huggingface dataset:
CHEMICAL WARFARE
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association Tests.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Harrison Antinarcotic Law
Authors: Hooper Alexander
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tonsillectomy Mortality
Authors: Donald W. Benson
Journal: JAMA (1966)

<h3>To the Editor:—</h3> The letter by Vincent J. Collins, MD, of Chicago deserves a tempering rebuttal. In the<i>Archives of Otolaryngology</i>(<b>82</b>:409, 1965), a study of the statistics garnered by the Baltimore Anesthesia Study Committee showed that there were 164,750 tonsillectomies done in the city of Baltimore from August 1953 to August 1964. In this group there were 17 deaths. Of the 17 deaths, 12 were considered to be associated with anesthesia and thereby related to an airway problem. Of these 12, eight had no endotracheal tube and four had an endotracheal tube. It is safe to say that in Baltimore better than 80% of all tonsillectomy anesthesias are given without an endotracheal tube. The authors conclude from this that the presence or absence of an endotracheal tube is not a significant factor, pointing out that asphyxia can occur with or without an endotracheal tube. In Acid-Base Balance During
Pre-emptive (early) transjugular intrahepatic porto-systemic shunt in the treatment of high-risk acute variceal bleeding. An individual patient data meta-analysis
Authors: Juan Carlos Garcia Pagan, Oana Nicoara-Farcau, Debora Angrisani, Alberto Monescillo, Guohong Han, Ferran Torres, Jaime Bosch, Georgina Casanovas, Yong Lv, Daiming Fan, Christophe Bureau, Frederik Nevens, Karel Caca, Angelo Luca, Alexander Zipprich, Bogdan Procopet, Alvaro Giraldez-Gallego, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibañez, Jonel Trebika, Joan Genesca, Jose María Palazon, José Castellote Alonso, Susana G. Rodrigues, Lise Lotte Gluud, Prof. Dr. Arnulf Ferlitsch, Carlos Alberto Costa Noronha Ferreira, Jose Luis Mundi, Henning Grønbæk, Romano Sassatelli, Alessandra Dell’Era, Marco Senzolo, Manuel Romero Gomez, Manuel Hernández Guerra, Meritxell Casas, Massimo Primignani, Aleksander Krag, José Luis Calleja Panero, Nuria Cañete, Helena Masnou, Joachim Mössner, Virginia Hernandez-Gea
Journal: Journal of Hepatology (2020)
The American Board of Internal Medicine
Authors: Edward Volpintesta
Journal: Annals of Internal Medicine (2015)

Letters6 January 2015The American Board of Internal MedicineEdward Volpintesta, MDEdward Volpintesta, MDFrom Bethel, Connecticut.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although Baron and Johnson (1) may not realize it (or maybe they do), the boards were never meant to be mandatory. This incontrovertible fact makes the moral basis for maintenance of certification (MOC) questionable to say the least. It is disappointing that Annals, which would never knowingly publish a scientific paper that contained such a conspicuous factual omission, saw fit to publish their commentary. It is just as disappointing (and misleading to readers) that this serious omission was not mentioned in Centor and colleagues' accompanying editorial (2).Edward Volpintesta, MDBethel, ConnecticutReferences1. Baron RJ, Johnson D. The American Board of Internal Medicine: evolving professional self-regulation. Ann Intern Med. 2014;161:221-3. [PMID: 24821363] doi:10.7326/M13-2478 LinkGoogle Scholar2. Centor RM, Fleming DA, Moyer DV. Maintenance of certification: beauty is in the eyes of the beholder [Editorial]. Ann Intern Med. 2014;161:226-7. [PMID: 24821483] doi:10.7326/M14-1014 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Bethel, Connecticut.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L14-0485. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe American Board of Internal Medicine: Evolving Professional Self-regulation Richard J. Baron and David Johnson The American Board of Internal Medicine: Evolving Professional Self-regulation Richard J. Baron and David Johnson The American Board of Internal Medicine Timothy Kleinschmidt The American Board of Internal Medicine Joseph J. Weiss The American Board of Internal Medicine Richard J. Baron and David Johnson The American Board of Internal Medicine Joseph J. Weiss The American Board of Internal Medicine Richard J. Baron and David Johnson The American Board of Internal Medicine Timothy Kleinschmidt Metrics 6 January 2015Volume 162, Issue 1Page: 75KeywordsConflicts of interestDisclosure ePublished: 6 January 2015 Issue Published: 6 January 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 4349: Predicting gene expression from plasma cell-free DNA using both the fragment length and fragment position
Authors: John A. St John, Erik Gafni, Brandon White, Ajay Kannan, Loren Hansen, Artur Jaroszewicz, Anshul Kundaje, Nathan Boley
Journal: Cancer Research (2019)

Abstract The ability to use a blood sample to determine the transcriptional state of cells that are releasing DNA into the bloodstream of a patient may be helpful in a variety of clinical applications. Here we present a case study of a gene expression prediction model that uses cell-free DNA (cfDNA) fragment coverage data generated by high-throughput sequencing to predict which genes are highly or lowly expressed in the cells contributing to that cfDNA. We evaluated a number of models, including a convolutional neural network that takes cfDNA fragment information (the density of both fragment midpoint and length by genomic position) over a transcription start site (TSS) as input, and outputs a predicted probability of whether that gene is highly expressed in cfDNA-producing cells. When we trained the convolutional model on a set of 554 genes with TSSs that were either constitutively expressed or unexpressed across leukocyte samples from the NIH Roadmap Epigenome Mapping Consortium, we achieved ~0.97 AUC in cross validation. With other models and splits of the data, we observed AUCs ranging from 0.95 to 0.99 on this gene-expression task. Next, we were interested in whether this trained model could answer specific clinical questions. For example, we hypothesized that we should see an increased influence of colon gene expression profiles in colorectal cancer patients with a higher fraction of circulating tumor DNA. To test this hypothesis, we applied our models to a set of genes with colon-specific expression, which generated a list of probabilities of each gene being expressed in each sample. We then applied simple models on the these lists of probabilities to predict whether a patient had CRC or was healthy. This yielded cross validation AUCs between 0.85 and 0.95 across many of the models we tested in differentiating healthy patients from colorectal cancer patients with tumor fraction over 5%. These results suggest a path forward for modeling transcriptional states using cfDNA sequencing data, which will enable greater insights from cfDNA that could augment those provided by other analytes. Citation Format: John A. St John, Erik Gafni, Brandon White, Ajay Kannan, Loren Hansen, Artur Jaroszewicz, Anshul Kundaje, Nathan Boley. Predicting gene expression from plasma cell-free DNA using both the fragment length and fragment position [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4349.
Formation and Repair of Psoralen-DNA Adducts and Pyrimidine Dimers in Human DNA and Chromatin
Authors: James E. Cleaver, Steven Killpack, Dieter C. Gruenert
Journal: Environmental Health Perspectives (1985)

DNA damage and repair in human cells exposed to ultraviolet light (254 nm) or to psoralen derivatives plus 360 nm light were compared by means of a variety of analytic techniques. The two kinds of damage show considerable structural similarity; both involve cyclobutyl bonds to 5,6 positions of pyrimidines as major products and have various minor products. In purified DNA, pyrimidine dimers, but not psoralen adducts, cause structural distortions that are substances for digestion with single-strand-specific nucleases. Whereas pyrimidine dimers are randomly produced in chromatin, psoralen adducts, are concentrated approximately 2- to 4-fold in linker regions of chromatin at doses that are not highly lethal. Chromatin shows considerable mobility; assignment of DNA to linker or core regions is not permanent, and psoralen adducts initially concentrated in linker regions become randomized after 10 hr. Pyrimidine dimers and psoralen adducts are excised by normal cells but not by repair-deficient xeroderma pigmentosum cells. This repair process requires DNA polymerase alpha, but its rate in ultraviolet-damaged cells is twice that in psoralen-damaged cells. Conversion of monoadducts to DNA-DNA crosslinks reduces the rate of repair because of the increased complexity of the damaged site.
Increased Peripheral Platelet Destruction and Caspase-3-Independent Programmed Cell Death of Bone Marrow Megakaryocytes in Myelodysplastic Patients.
Authors: Ewout J. Houwerzijl, Nel R. Blom, Johannes J.L. van der Want, Henk Louwes, Mariet T. Esselink, Jan W. Smit, Edo Vellenga, Joost Th.M. de Wolf
Journal: Blood (2004)
Understanding hepatic regeneration.
Journal: BMJ (1981)

on the incidence, aetiology, and prognosis of the condition are still premature.As regards management, most authorities now recommend prophylactic antibiotic cover against bacterial endocarditis when there is a murmur, but not when a click is the only sign23; anticoagulant treatment is not justified unless there has been evidence of systemic emboli.Above all the physician must steer the difficult course between engendering anxiety by overconcern and investigation and treating un- sympathetically symptoms such as atypical chest pain, which may seem neurotic but which are likely to have a physical basis.
Cancer of the head and neck. Hypopharynx and larynx. 1
Authors: P. Rubin
Journal: JAMA (1972)

A shift of a few millimeters to a centimeter alters the entire prognosis and treatment of lesions of the hypopharynx and larynx. Therefore, details of topographic anatomy should precede any in-depth discussion of this subject. Although the structural components of the larynx can be assessed by indirect as well as by direct laryngoscopy, they should be correlated with radiographic anatomy. For the oncologist, therefore, a three-dimensional view of the anatomy is essential. Diagrams of the midcoronal, sagittal, and cross-sectional planes are the obvious prerequisites in a review of the basic anatomy and comprehension of its many details (Fig 1). The skeletal framework of cartilages, the ligamentous connections, and muscular attachments form the inner frame of the hypopharynx. There are six cartilaginous structures in addition to the hyoid bone; they are the epiglottic, thyroid, cricoid, cuneiform, corniculate, and arytenoid cartilages. Ligamentous and muscular attachments interlock these pieces into a functional whole
Maternity Nursing in a Nutshell.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human T-Lymphotropic Virus Type II Among Guaymi Indians—Panama
Journal: JAMA (1992)

Human T-lymphotropic virus type 2 (HTLV-II) is one of four retroviruses (i.e., HTLV-I, human immunodeficiency virus type 1 [HIV-1], and HIV-2) that are known to infect humans. During 1988, investigators from the Gorgas Memorial Laboratory (GML) and the National Institutes of Health (NIH) tested serum specimens collected during 1978-1987 throughout Panama to determine the prevalence of HTLV-I infection (1), which is endemic in southern Japan and the Caribbean basin (2). HTLV seropositivity rates were low in all areas of Panama except among the Guaymi Indians in Changuinola (9%),* a city in western Panama (Figure 1). During 1989-1991, additional testing of 36 seropositive specimens from Guaymi Indians detected that the infections were due to HTLV-II (3,4). This report summarizes risk factor data for HTLV-II infection among Guaymi Indians.
Poster Sessions 2
Journal: Allergy (2012)

Background: In Italy, epidemiological studies on respiratory and allergic diseases in 3-5 years old children are not been conducted.The purpose of our study is to evaluate the prevalence of respiratory and allergic diseases of 3-5 years old children.Methods: The study includes 3-5 years old children, who attend the nursery in Rome.Standardized questionnaires, by the protocol SIDRIA-2, were distributed at school and filled out by parents.Only for the families concerned, the SPT were performed for inhalant and foods allergens.
The Ritalin controversy: what's made this drug's opponents hyperactive?
Authors: V. S. Cowart
Journal: JAMA (1988)

A WAVE OF ADVERSE publicity involving methylphenidate hydrochloride (Ritalin), a drug that has been used for more than 30 years to treat children and adults with attention-deficit hyperactivity disorder, has created concern that public opinion may eventually affect medical practice. There appears to be growing belief on the part of some of the public that the drug has dangerous side effects, that schools want to have it prescribed, and that psychiatrists are eager to label children as having a condition that may not even exist. Among the recent developments: A suit was filed in Georgia against a public school district and against the American Psychiatric Association. At least eight medical malpractice suits have been filed, five of them recently in Massachusetts. The defense attorney for a 15-year-old youth convicted of killing a classmate with a baseball bat argued that his client's behavior may have been affected by taking methylphenidate. All
The interpretation of thyroid function tests in hospitalized patients
Authors: J. E. Morley
Journal: JAMA (1983)

NUMEROUS studies have demonstrated a high incidence of unsuspected hyperthyroidism and hypothyroidism in hospitalized patients.<sup>1,2</sup>In general, thyroid dysfunction is present in 2% to 5% of short-term hospitalized subjects and patients in long— term medical or psychiatric nursing facilities. Increased awareness of this high incidence, coupled with the problem that the clinical diagnosis of thyroid dysfunction in patients with other concomitant diseases, has resulted in an increase in screening for thyroid disorders. This increase in the ordering of thyroid function tests has led to the discovery that many hospitalized patients have abnormal findings on thyroid function tests that are unrelated to underlying thyroid disorders. The purpose of this review is to describe the multiple syndromes of altered thyroid function that have been reported in hospitalized patients and to develop a simple, cost-effective approach to thyroid function screening in these patients. <h3>Low Triiodothyronine Level and Low Thyroxine Level Syndromes: The</h3>
Corrections to “De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017”
Authors: G. Curigliano, H.J. Burstein, E. P. Winer, M. Gnant, P. Dubsky, S. Loibl, M. Colleoni, M.M. Regan, M. Piccart-Gebhart, H.-J. Senn, B. Thürlimann, F. André, J. Baselga, J. Bergh, H. Bonnefoi, S. Y. Brucker, F. Cardoso, L. Carey, E. Ciruelos, J. Cuzick, C. Denkert, A. Di Leo, B. Ejlertsen, P. Francis, V. Galimberti, J. Garber, B. Gulluoglu, P. Goodwin, N. Harbeck, D.F. Hayes, C.-S. Huang, J. Huober, H. Khaled, J. Jassem, Z. Jiang, P. Karlsson, M. Morrow, R. Orecchia, K.C. Osborne, O. Pagani, A.H. Partridge, K. Pritchard, J. Ro, E.J.T. Rutgers, F. Sedlmayer, V. Semiglazov, Z. Shao, I. Smith, M. Toi, A. Tutt, G. Viale, T. Watanabe, T.J. Whelan, B. Xu
Journal: Annals of Oncology (2019)
Soft Tissue Sarcoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology
Authors: Margaret von Mehren, R. Lor Randall, Robert S. Benjamin, Sarah Boles, Marilyn M. Bui, Ernest U. Conrad, Kristen N. Ganjoo, Suzanne George, Ricardo J. Gonzalez, Martin J. Heslin, John M. Kane, Henry Koon, Joel Mayerson, Martin McCarter, Sean V. McGarry, Christian Meyer, Richard J. O'Donnell, Alberto S. Pappo, I. Benjamin Paz, Ivy A. Petersen, John D. Pfeifer, Richard F. Riedel, Scott Schuetze, Karen D. Schupak, Herbert S. Schwartz, William D. Tap, Jeffrey D. Wayne, Mary Anne Bergman, Jillian Scavone
Journal: Journal of the National Comprehensive Cancer Network (2016)

Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Guidelines for Soft Tissue Sarcoma (available at NCCN.org) provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as intra-abdominal/retroperitoneal STS, gastrointestinal stromal tumor, desmoid tumors, and rhabdomyosarcoma. This manuscript discusses guiding principles for the diagnosis and staging of STS and evidence for treatment modalities that include surgery, radiation, chemoradiation, chemotherapy, and targeted therapy.
Studies with 1,2-Dithiole-3-Thione As a Chemoprotector of Hydroquinone-Induced Toxicity to DBA/2-Derived Bone Marrow Stromal Cells
Authors: Lorraine E. Twerdok, Stephen J. Rembish, Michael A. Trush
Journal: Environmental Health Perspectives (1993)

Stromal cells from DBA/2 mouse bone marrow have been shown to be susceptible to cytotoxicity induced by several redox-active metabolites of benzene, including hydroquinone (HQ). Treatment with HQ also alters the composition of stromal cell populations by preferentially killing stromal macrophages compared to stromal fibroblasts. This cytotoxicity can be prevented by 1,2-dithiole-3-thione (DTT) as a result of the induction of quinone reductase (QR), a quinone-processing enzyme, and glutathione. The inductive activities of DTT protected stromal cells against HQ-induced cytotoxicity and against HQ-induced impairment of stromal cell ability to support myelopoiesis. In vivo feeding of DTT to DBA/2 mice increased QR activity within the bone marrow compartment and protected bone marrow stromal cells isolated from the DTT-fed animals from ex vivo HQ challenge. Thus, the inducibility of cellular defense mechanisms and xenobiotic-processing enzymes by chemoprotective agents such as DTT may be a useful strategy for protecting against chemically induced bone marrow toxicities.
ERCP
Authors: Emmanuel Toussaint, Marianna Arvanitakis
Journal: Endoscopy (2014)

Endoscopy Essentials Reviews in the Endoscopy Essentials series cite publications from the past year which, in the authors’ opinion, reflect the state-of-the-art in endoscopy. Alongside a short summary of each paper, authors explain why they consider their selected articles to be of importance.