tbuckley/cabot-search huggingface dataset:
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Authors: Udai S. Kammula, Daniel G. Coit
Journal: Journal of Clinical Oncology (2005)

A recent study of 308 paraffin-embedded SLNs, from 215 patients with clinically node-negative melanoma, compared intensive H&E/IHC analysis of serially-sectioned SLNs against a quantitative, real-time, multiple-marker RT-PCR assay, using the tumor-associated markers MART-1, MAGE-A3, GalNAc-T, and Pax3.Follow-up was in excess of 8 years for all patients.A total of 25% of patients had histopathologically positive SLNs (ie, positive by H&E or/and IHC).Among the patients with histopathologically negative SLNs, 30% were positive for at least one RT-PCR marker.The risk ratio for disease recurrence in the patients with histopathologically negative but RT-PCR-positive SLNs was 7.48 (P Ͻ .0001)when compared with patients with SLNs that were negative by both histopathologic evaluation and by RT-PCR.The risk ratio for decreased overall survival in the RT-PCRpositive group of patients (with histopathologically negative SLNs) was 11.42 (P ϭ .0002).Finally, an increasing number of positive RT-PCR markers was associated with a decreased overall survival (P Ͻ .0001). 11These results comport well with other recent studies utilizing multiple-marker RT-PCR assays to evaluate the SLNs and blood of patients with melanoma, including patients with long-term follow-up. 12 Despite these concerns, the authors are to be congratulated for their long-term study of patients with early stage melanoma, and for their important contributions to the emerging field of molecular tumor staging.
PSEUDO-CHANCRE.
Authors: WILLIAM S. GOTTHEIL
Journal: JAMA (1896)

Few syphilographers doubt the existence of syphilitic reinfection, but most of them regard it as an occurrence of extreme rarity. The literature teems with recorded cases; but an exact analysis shows that the vast majority of them is open to grave doubt. They are either cases of manifestly incorrect diagnosis, or they are cases so imperfectly recorded that they lose all value as evidence in this much disputed subject. Until the middle of this century the law of Ricord obtained universal acceptance. Syphilitic immunity, once established, was supposed to last during the remaining life of the patient. And the exceptions that were noted were so infrequent and so insufficiently proven that they detracted nothing from the validity of the general proposition. Petit, Fournier, and the entire Parisian school accepted it absolutely. In the year 1858, however, renewed attention to these exceptions was called by Zeisse.<sup>1</sup>He showed conclusively that
Water-Borne Infectious Hepatitis
Authors: James W. Mosley
Journal: New England Journal of Medicine (1959)

Epidemiologic DataPlace of OccurrenceSix of the 28 epidemics (21 per cent) occurred in towns and cities of over 3000 population served by a municipal system. Five (18 per cent) were in villages, and 1 (4 per cent) was in a rural area, having only multiple private supplies. The remaining 16 involved groups exposed to private supplies serving institutions, industrial plants, resort hotels and summer camps.This distribution is very similar to that seen in outbreaks of gastroenteritis, diarrhea, dysentery and typhoid in the United States during the period 1938 through 1945.50 Approximately 70 of the 320 epidemics listed . . .
Role of Mathematical Concepts in Cancer Research
Authors: Shun-ichi Yamamoto
Journal: Environmental Health Perspectives (1979)

The role of mathematics in cancer research is not confined to epidemiology (population level). The expected contribution of it in various levels is exemplified stepwise. At the individual level, prediction of life expectancy of a cancer case or psychological analysis of life-threatened patient; at the tissue level, stochastic estimation of future metastases; at the cellular level, model contruction for abnormal metabolic processes in malignant cell; at the molecular level, elucidation of carcinogenetic mechanism from a thermodynamic standpoint of view.
Dobutamine therapy in acute myocardial infarction
Authors: E. C. Keung
Journal: JAMA (1981)

The short-term response of combined dopamine hydrochloride-sodium nitroprusside therapy was compared with administration of dobutamine in eight patients with acute myocardial infarction complicated by hypotension and severe left ventricular dysfunction. All patients were receiving dopamine before the study began. The addition of sodium nitroprusside increased cardiac index (CI) from 1.94±0.49 to 2.22±0.48 L/min/sq m; decreased left ventricular filling pressure (LVFP) from 28.9±3.5 to 19.9±3.3 mm Hg and mean systemic arterial pressure (MAP) from 82.1±5.1 to 71.5±6.0 mm Hg. During dobutamine infusion, CI, LVFP, and MAP were 2.33±0.31 L/min/sq m, 20.8±4.8 mm Hg, and 74.1±8.1 mm Hg, respectively. There was no statistical difference between short-term hemodynamic benefits produced by dobutamine or combined dopamine-sodium nitroprusside therapy. Dobutamine, a synthetic catecholamine, provides a substitute for dopamine-sodium nitroprusside therapy in acute myocardial infarction. Dobutamine has the advantage of being a single agent and is therefore easier to administer. (<i>JAMA</i>1981;245:144-146)
Ordering of laboratory tests in a teaching hospital. Can it be improved?
Authors: E. T. Wong
Journal: JAMA (1983)

A review of ordering patterns for thyroid function tests and for measurements of creatine kinase (CK) isoenzyme and lactate dehydrogenase (LDH) isoenzyme levels indicated considerable misuse. We employed an educational program for both types of tests, but changed the request form only for ordering the thyroid function tests. No changes were made in the forms for ordering CK and LDH isoenzyme tests. The effect was a prompt decrease in ordering triiodothyronine radioimmunoassay and thyrotropin tests to 38% and 61%, respectively, of baseline rates. There was no effect on rates of ordering CK and LDH isoenzyme tests, which were 102% and 96%, respectively, of baseline rates. The improved use of thyroid function tests was likely because of the change in the laboratory request form, since the educational strategy by itself had no effect on the ordering of CK and LDH isoenzyme tests. (<i>JAMA</i>1983;249:3076-3080)
THE RIGHT TO DIE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COLLEGE ATHLETICS AND HEALTH
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NEW FORENSIC METHOD OF DIFFERENTIATING HUMAN AND ANIMAL BLOOD.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Asthma and wheezy bronchitis in childhood.
Journal: BMJ (1973)

Asthma and Wheezy Bronchitis in ChildhoodAttacks of wheezing are among the commonest illnesses of childhood that general practitioners are called upon to treat.Two studies carried out in general practice showed that at least 20% of children had had one or more attacks during their first ten years of life.1 2 Some authors consider that the term asthma should be applied to any child who is subject to wheeze.Othersl-3 reserve the term for those children whose wheezing is provoked by such stimuli as exercise, allergens, and emotional disturbance, and exclude children in whom recur- rent attacks of wheezing occur only in association with respira- tory infection.The terms "wheezy bronchitis" and "pseudoasthma"3 are often used to describe the disease in this group of children.
time capsule
Authors: Akshay Pendyal
Journal: Annals of Internal Medicine (2015)

Ad Libitum5 May 2015time capsuleAkshay Pendyal, MDAkshay Pendyal, MDFrom Portland, Oregon.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-0193 Audio Reading - “time capsule” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "time capsule," by A. Pendyal. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail after the new hearthas been interredinto the chest'sempty crucible,it is restarted.slowly at first,but then building steam,allowing its accumulated contentsto seepinto unaccustomed earth.memories (like that of the tin lunchbox,caked with sand andcarrying the afternoon's spoils,briny seashells and smoothed pebbles;or of popsicles whose juice wassticky on interlocked fingers)flow in rivulets,terminating in capillary bedsand laying dormant.so that years later,after the graft had taken holdand was now firmly your own,you abruptly felton the back of your tongue,in your nostrils,against your skinsalta soft breezethe sun's warmth—sensations both unfamiliarand as old as time.Akshay Pendyal, MDPortland, Oregon Author, Article, and Disclosure InformationAffiliations: From Portland, Oregon.Current Author Address: Akshay Pendyal, MD; e-mail, akshay.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “time capsule” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "time capsule," by A. Pendyal. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 5 May 2015Volume 162, Issue 9Page: 667KeywordsCapillariesHeartMemorySaltsThoraxTongue ePublished: 5 May 2015 Issue Published: 5 May 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effect of Climate Change on Allergenic Airborne Pollen in Japan (2)
Authors: Reiko Kishikawa, Akemi Saito, Norio Sahashi, Eiko Koto, Chie Oshikawa, Nobuo Soh, Toshitaka Yokoyama, Tadao Enomoto, Toru Imai, Koji Murayama, Yuma Fukutomi, Terufumi Shimoda, Tomoaki Iwanaga
Journal: Journal of Allergy and Clinical Immunology (2016)
Disinfection By-Products in Drinking Water: Critical Issues in Health Effects Research
Authors: John Fawell, Denise Robinson, Richard Bull, Linda Birnbaum, Gary Boorman, Byron Butterworth, Phillippe Daniel, Hend Galal-Gorchev, Fred Hauchman, Paivi Julkunen, Curtis Klaassen, Stuart Krasner, Jennifer Orme-Zavaleta, John Reif, Robert Tardiff
Journal: Environmental Health Perspectives (1997)
Medical maladies as seen by the artist
Authors: J. H. Talbott
Journal: JAMA (1981)

Despite rewarding but sporadic attempts by a few physicians to identify and document the specifics of medical afflictions as they have been seen through the eyes of the artist, a treasure trove of real or symbolic depiction of disease still lies fallow in museums and galleries throughout the world. Gout, a readily recognized type of arthritis, is a notable example, especially as portrayed in England in the caricatures of the early part of the 19th century. In a delightful essay titled "Gout in the Time and Person of George IV: A Case History," Bywaters<sup>1</sup>reproduced a number of caricatures in color of Arbuthnot's John Bull or the real Prince Regent, later George IV, afflicted with chronic tophus gout. The Cruickshanks and Rowlandson, Gillray, and others were particularly prolific at this time in their portrayal of the miseries of gout (see, eg, covers Jan 23, 1967; Feb 5, 1969; Feb
Role of Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia Treated with Arsenic Trioxide in Frontline Therapy
Authors: Ezhilarasi Chendamarai, Poonkuzhali Balasubramanian, Biju George, Kavitha M Lakshmi, Auro Viswabandhya, Aby Abraham, Rayaz Ahmed, Ansu Abu Alex, Saravanan Ganesan, Mammen Chandy, Alok Srivastava, Vikram Mathews
Journal: Blood (2011)
The New Mexico Medical Society.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Celiac Disease
Authors: Joshua Elliott Rubin, Sheila E. Crowe
Journal: Annals of Internal Medicine (2020)

Gluten-related disorders, including celiac disease, wheat allergy, and nonceliac gluten sensitivity (NCGS), are increasingly reported worldwide. Celiac disease is caused by an immune-mediated reaction to ingested gluten in genetically susceptible persons. NCGS is largely a diagnosis of exclusion when other causes of symptoms have been ruled out. All patients with celiac disease should be referred to a registered dietitian nutritionist with expertise in celiac disease and a gastroenterologist who specializes in celiac disease and malabsorptive disorders, and they should remain on a strict gluten-free diet indefinitely. This article provides an overview of gluten- and wheat-related disorders.
An unusual manifestation of non-Hodgkin's lymphoma. Fibrosis masquerading as Ormond's disease
Authors: P. W. Dlabal
Journal: JAMA (1980)

NODULAR poorly differentiated lymphocytic lymphoma (NLPD) and idiopathic retroperitoneal fibrosis (IRF), or Ormond's disease,<sup>1</sup>are protean in their manifestations. Lymphoma occurs in virtually every organ, and IRF involves many areas outside the retroperitoneum, including the testis and brain. We describe a case that was erroneously reported as IRF involving the spinal cord<sup>2</sup>but, on further analysis, has been shown to be a classic case of non-Hodgkin's lymphoma in which sclerosis is a prominent feature. Fibrosis, the factor that obscured the diagnosis, may have had important prognostic implications. <h3>Report of a Case</h3> A 67-year-old woman was informed that she had Brill-Symmer's disease (giant follicular lymphoma) based on findings from a cervical node biopsy done at another hospital in 1956. She was well with no therapy until 1967 when she came to Wilford Hall US Air Force Medical Center with flank pain and right hydronephrosis. At ureterolysis, performed in August
Effects of Inhaled Acids on Respiratory Tract Defense Mechanisms
Authors: Richard B. Schlesinger
Journal: Environmental Health Perspectives (1985)

The respiratory tract is endowed with an interlocking array of nonspecific and specific defense mechanisms which protect it from the effects of inhaled microbes and toxicants, and reduce the risk of absorption of materials into the bloodstream, with subsequent systemic translocation. Ambient acids may compromise these defenses, perhaps providing a link between exposure and development of chronic and acute pulmonary disease. This paper reviews the effects of inhaled acids upon the nonspecific clearance system of the lungs.
Melasma induced by oral contraceptive drugs
Authors: S. Resnik
Journal: JAMA (1967)

In a clinic group of 212 patients taking an oral contraceptive agent, melasma developed in 61 (29%) as a direct result of the drug. Both combination and sequential oral contraceptives showed the capability to produce this facial hyperpigmentation, which does not completely regress after cessation, in contrast to melanoderma in pregnancy. It appears that continued use of the newer oral contraceptive agents will lead to the conclusion that all are capable of producing hyperpigmentation. Eighty-seven percent (52 of 61) having melasma from oral contraceptives also had melanoderma during pregnancy. Thus, melasma in pregnancy can be used as an indicator in detecting the susceptible individual. The perplexing question of estrogen or progesterone as the cause of melasma remains unanswered. No lessening in the incidence of melasma could be found with decreased dosage in estrogen component.
Diabetic Cardiomyopathy
Authors: Frederick S Fein
Journal: Diabetes Care (1990)

The purpose of this article was to review the clinical and experimental features of diabetic cardiomyopathy, with particular relevance to the Black population. One hundred thirty-seven studies were identified, of which 57 were selected as references for this article. Diabetes is associated with the development of cardiomyopathy, independent of coronary atherosclerosis. Pathological studies show myocardial hypertrophy and fibrosis; microvascular pathology is also present, but all of these pathological findings have an uncertain relationship to myocardial failure. Hemodynamic findings of both congestive and restrictive cardiomyopathy have been described. Noninvasive studies revealed abnormal systolic and diastolic function in many diabetic subjects, particularly in the presence of diabetic complications and/or hypertension. Experimental studies have focused on the mildly diabetic dog and the severely diabetic rat. One year of diabetes in dogs resulted in decreased left ventricular compliance and increased interstitial connective tissue. Studies in the diabetic rat showed a marked slowing of contraction and relaxation. Chronic insulin therapy reversed the changes in the rat model. Combining hypertension with diabetes in the rat resulted in increased myocardial and coronary microvascular pathology and greater changes in isolated muscle function, electrophysiology, and contractile protein biochemistry. Many hypertensive diabetic rats died spontaneously, showing signs of congestive heart failure. Diabetic cardiomyopathy is a significant cause of heart failure in diabetic subjects and occurs more frequently in those with microvascular complications and/or hypertension. Clinical studies are needed to clarify the natural history of this disorder, focusing on the benefits of tight control of hyperglycemia and treatment of associated hypertension. Experimental studies will clarify the pathophysiology and contribute to improved therapy. The high prevalence of diabetes and hypertension in Blacks makes these considerations especially relevant to this population.
Respiratory distress in the newborn
Authors: L. K. Miller
Journal: JAMA (1980)

RESPIRATORY distress in the newborn can occur after any delivery, but should be anticipated in high-risk infants, such as those born prematurely, after a difficult labor, by cesarean section, or of diabetic mothers. Respiratory distress in the neonate must be evaluated quickly and appropriate therapy planned, including transfer to a neonatal intensive care unit. A chest roentgenogram is essential to differentiate among the myriad causes of respiratory distress, which encompass medically and surgically treatable conditions. Most of the time a cribside roentgenogram is obtained. The technique is simple, is not disturbing to the newborn, and produces roentgenograms of diagnostic quality. <h3>Wet Lung Disease</h3> A common cause of respiratory distress in the immediate newborn period is wet lung disease. Clinically, neonates with wet lung disease have tachypnea shortly after birth, which clears quickly within two to five days. A delay in the resorption of pulmonary alveolar fluid is common. The fluid