tbuckley/cabot-search huggingface dataset:
Some Remarks on Alleged Degeneracy
Authors: W D Howle
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Self-Experimentation
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemistry of Muconaldehydes of Possible Relevance to the Toxicology of Benzene
Authors: Christine Bleasdale, Gordon Kennedy, James O. MacGregor, Jens Nieschalk, Kirsty Pearce, William P. Watson, Bernard T. Golding
Journal: Environmental Health Perspectives (1996)

ZZ)-Muconaldehyde reacted with primary amines to give N-substituted-2-(2'-oxoethyl)-pyrroles, which were reduced to N-substituted-2-(2'-hydroxyethyl)-pyrroles by sodium borohydride.The pyrrole-forming reaction is exhibited by valine and its methyl ester, and is being developed with terminal valine in hemoglobin as a means of dose monitoring (Z,Z)-muconaldehyde, a putative metabolite of benzene.Reactions in aqueous solution between (Z,Z)-muconaldehyde and adenosine, deoxyadenosine, guanosine, or deoxyguanosine leading to pyrrole-containing adducts are described.The elucidation of the structures of the adducts was assisted by the study of reactions between (Z,Z)-muconaldehyde and both nucleoside derivatives and a model compound for guanosine.Reactions of (Z,Z)-muconaldehyde are complicated by its isomerization to (E,Z)- and (E,E)-muconaldehyde.The kinetics of this process have been studied in benzene, acetonitrile, and dimethylsulfoxide.-
Penicillamine in the treatment of patients with cystiuria
Authors: W. B. MacDonald
Journal: JAMA (1966)

Contrary to the usual statements that cystinuria is a medical curiosity and a benign disease, observations of 16 individuals, including seven children, have shown that the consequences of cystine stone formation are of such serious nature as to markedly shorten life expectancy and induce both physical and mental anguish in involved persons. Thus, therapy directed toward the removal of the offending urinary cystine is warranted. This study shows the unequivocal value of penicillamine administered orally to patients with cystinuria; penicillamine will lower urinary cystine to levels which have not allowed further stone development in the treated individuals during the trial observation period. Further, early side effects have been surmounted, and no late effects have been noted up to one year of treatment. Suggested dosage of penicillamine is 30 mg/kg of body weight per day.
Medical Malpractice
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1975)

Medical liability insurance is in a state of emergency brough on by escalating premiums or withdrawal of insurance companies from the market. Solutions, supported by legislation, must be sought for the sake of both patient and physician. As a temporary method of correction joint underwriting associations appear to be the most practical suggestion. Long-range changes should include the establishment of powerful malpractice arbitration boards whose conclusions and evidence would be submitted in case of further appeal, the delegation of more power to the medical profession to enforce standards, shortening of the period specified in the statutes of limitation, limitations on contingency fees, and elimination of the applicability of such legal doctrines as ad damnum clauses and res ipsa loquitur.
BMA congress, Toronto, 20-23 September 1983
Journal: BMJ (1983)

The 1983 BMA Congress in Toronto will be the seventh annual clinical meeting to be held outside Europe.The association last met in Toronto in 1955, when a joint annual meeting was held with the Canadian Medical Association.The theme of the congress will be "Growing Points in Medicine and their Impact on Patients," and the clinical sessions will be held from 20 to 23 September at the Sheraton Centre Hotel, Toronto.The British speakers will include Professor Dame Sheila Sherlock (London) on "The Rising Tide of Alcoholism" and Mr Terence English (Cambridge) on "The Present and Future Role of Cardiac Transplantation."Other subjects to be discussed include: Paediatrics: the severely handicapped child; asthma in children.Is your test really necessary ?: tests in gastroenterology; routine blood tests.The value of imaging techniques to consultants and general practitioners: ultrasonography; computed tomography.Psychosexual counselling.Different approaches to therapy: hypnosis: biofeedback.
Growth
Authors: Renata Gaddini
Journal: Psychotherapy and Psychosomatics (1979)

<i>Freud's</i> concepts on the innate and the experiential, applied as they were essentially to the psychic structure, are discussed because, as <i>Winnicott</i> (1952) indicates, 'the psyche grows out of the soma almost from birth' (see also <i>Bion</i>, 1962). The maternal function is basic to the growth in the first months and, to a lesser extent, is basic all through the growing process, which is particularly fast and demanding during the first three years. The fact that the 'maternal function', essential for growth in the early stage, is comprised of events which the baby either experiences or is lacking, such as bodily early contacts, being held in the arms and the quality of holding, eye to eye communication on which baby's apperception develops is underlined. The quality of early physical care is to be seen, in the author's view, as the food on which basic individual growth takes place. Deviations and distortions of growth, where no genetic and/or organic explanation may be found, have to be studied in this light. This is particularly true with young babies, where maternal deprivation is a frequent cause of malnutrition.
The Lumleian Lectures on the Digestive Ferments, and the Preparation and Use of Artificially Digested Food
Authors: W. Roberts
Journal: BMJ (1880)

VARIOUS kinds of albhiminious r 'pr6teid subgtances are used by imankind as food.Tl;e most important of these are muscular flesh, the casein 'ei tailk, d .eggSalbumfrom t-he animal kingdom-and gluten, albttmen, 'and leg'min from-the vegetable kingdoms Proteids are attackded by the digestive ferments-at ttwo points in the alimentary canal, by pepsih in' the, stomach and by trypsin i' the'sil intestinie.Between' these_ two :cts_ of digestipn th,ere s'i agoa,ptte break-in the duotleduai oawirtg toi4w,'fflpt dge of rea,tion frc -acid-to alkaline .wshicurs at-ath o -oit.Gastri;c' digestion is, in all creaitret, -an 'essentially acid digestion; but the most varie!oplifons ha'vg been entertained as to the nature of the acid.'It has' be siu-ppsea pj tarn to be hydrochloric acid, lactic acid, acid phosphate of Jifne, batyriq gcid, and even acetic acid.Muchof this 'confusion has arisen from -not distinguishing between .theatid of pure gastric juice as secreted AihtO at empty stomach, and the acid-of the gastric contents 'diing tlihe igeStion of a meal.A' g6od' deal of ititis:n Wn et " by the.recet researches of C.
An alternative staffing proposal for emergency rooms. Three-year experience in a rural hospital
Authors: H. M. Golomb
Journal: JAMA (1974)

Evaluation of emergency room visits of 2,505 patients seen by one physician in a rural community hospital during a three-year period demonstrated that approximately one third of the visits were truly urgent, and that approximately one half of the patients could have received medical care by a physician's assistant alone. As the demand for emergency room services continues to increase out of proportion to the local population increase, new concepts for coverage need to be devised. Once need is established for more than one physician, a physician's assistant should be utilized as the second member of the team. (<i>JAMA</i>228:329-331, 1974)
A phase 1, dose-escalation, safety, pharmacokinetic, pharmacodynamic study of thioureidobutyronitrile, a novel p53 targeted therapy, in patients with advanced solid tumors.
Authors: Geoffrey Shapiro, James Walter Mier, John Frederick Hilton, Leena Gandhi, Nicole G. Chau, Andrea J. Bullock, Jeffrey G Supko, Sigitas Jonas Verselis, Kayla Murgo, Cameron Sze, Susan Gotthardt, Andrew Wolanski, W. James Alexander, Ashok Kumar, Sylvia Adell Holden, Karima Chafai-Fadela, Siya Ram, Krishna E. Menon
Journal: Journal of Clinical Oncology (2015)

TPS2613 Background: Thioureidobutyronitrile, Kevetrin, induced apoptosis in wild type p53, mutant p53 and p53 null cell lines. In A549 lung carcinoma cells, wild type p53 was stabilized by Kevetrin. Kevetrin induced nongenotoxic activation of the p53 signaling pathway. Kevetrin also induced p21 and PUMA, known transcriptional targets of p53. Kevetrin caused accumulation of monoubiquitinated p53 and induced transcriptional independent apoptosis. In p53 mutant breast carcinoma cells (MDA-MB-231), Kevetrin induced degradation of hyperstable oncogenic mutant p53 and induced apoptotic cell death. Apoptotic cell death was also induced in K-562, a p53 null CML cell line. Consistent with in vitro data, Kevetrin showed potent antitumor activity in wild type p53 (A549), mutant p53 (MDA-MB-231), and p53 null (K-562) human tumor xenograft models. Kevetrin has the unique ability to target both wild type and mutant p53 tumors controlling tumor growth in various preclinical tumor models (ASCO 2013). Based on the pre-clinical data, a Phase I study was initiated at Dana-Farber/Harvard Cancer Center in 2012. Methods: Adults with refractory locally advanced or metastatic solid tumors, acceptable liver, kidney function, and hematologic status were eligible. Objectives include determination of DLT, MTD, pharmacokinetics, pharmacodynamics, and evaluating preliminary evidence of antitumor activity. Kevetrin is given as an intravenous infusion once weekly for 3 weeks in 28-day cycles. The starting dose was 10 mg/m2. In a 3+3 design, groups of 3-6 patients are evaluated for toxicity at each dose level. Dose escalation is based upon the number and intensity of adverse events in cycle 1. Kevetrin PK is characterized for the first and last doses given in cycle 1. Kevetrin induced p21 in lymphocytes preclinically; therefore p21 expression in peripheral blood mononuclear cells is measured as a PD biomarker. Antitumor activity by RECIST 1.1 criteria and serum tumor markers is assessed. The p53 status of tumors of selected patients will be determined. The first nine cohorts were completed in December 2014. Enrollment in the tenth cohort at 450 mg/m2 began January 2015. Clinical trial information: NCT01664000.
Morbidity of acute pancreatitis: the effect of aprotinin and glucagon.
Authors: J Gilmore, C Mackay, J Trapnell, Mr Williamson
Journal: Gut (1980)

Abstract In a double-blind, randomised trial, neither aprotinin nor glucagon given in relatively high doses for five days influenced the rate of recovery or incidence of complications in 257 patients with acute pancreatitis.
Abstract 3027: Pharmacological regulation of the ABCG2 multidrug transporter in A549 non-small cell lung cancer cells
Authors: Daniella Kovacsics, Nikolett Mészáros, Borbála Tihanyi, Zsolt Matula, Adrienn Borsy, Edit Szabó, György Várady, Tamás Orbán, Ágota Apáti, Ábel Fóthi, Anna Brózik, Balázs Sarkadi
Journal: Cancer Research (2019)

Abstract The notoriously drug resistant non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths and the ABCG2 multidrug transporter was shown to be involved in NSCLC drug resistance. Direct drug interactions with this transporter have been extensively studied, while a potential modulation of ABCG2 expression by drugs or hormones is less explored. To study the drug-dependent regulation of ABCG2 expression, we used CRISPR-Cas9 and homologous recombination-mediated DNA repair to generate fluorescent lung cancer reporter cells with preserved endogenous regulatory regions. In A549 lung adenocarcinoma cells, which have two wild type copies of the ABCG2 gene, we replaced the initial coding region of ABCG2 with a green fluorescent protein (eGFP)-coding sequence. In addition, since our previous studies demonstrated that an N-terminally eGFP-tagged ABCG2 protein is properly localized and functional, we have generated A549 cells in which the native ABCG2 coding region was modified to express an eGFP-tagged ABCG2 protein. The eGFP knock-in cells sensitively reported ABCG2 transcriptional regulation, while the cells expressing an eGFP-ABCG2 fusion protein allowed the assessment of the full, functional transporter. Using the engineered A549 cells, we found that several drugs, including anti-cancer medications, glucocorticoids, HDAC inhibitors and hypoxia-mimicking agents, caused a significant induction of ABCG2 expression. In these experiments, an intronic regulatory element was found to play a key role in the specific glucocorticoid induction of ABCG2. We suggest that our transgenic reporter cell lines, amenable to high-throughput studies, can be used to investigate the induction of ABCG2-based drug resistance in cancer and predict potential drug-drug interactions. Understanding how the generation of drug-tolerant persister cells occurs via ABCG2 expression may help the selective elimination of these multidrug resistant cancer cells. Supported by the NKFIH-OTKA grant K115375. Citation Format: Daniella Kovacsics, Nikolett Mészáros, Borbála Tihanyi, Zsolt Matula, Adrienn Borsy, Edit Szabó, György Várady, Tamás Orbán, Ágota Apáti, Ábel Fóthi, Anna Brózik, Balázs Sarkadi. Pharmacological regulation of the ABCG2 multidrug transporter in A549 non-small cell lung cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3027.
Measurement of Chromosomal Aberrations, Sister Chromatid Exchange, hprt Mutations, and DNA Adducts in Peripheral Lymphocytes of Human Populations at Increased Risk for Cancer
Authors: David Jacobson-Kram, Richard J. Albertini, Richard F. Branda, Michael T. Falta, P. Thomas Iype, Ken Kolodner, Saou-Hsing Liou, Melissa A. McDiarmid, Marcia Morris, Janice A. Nicklas, J. Patrick O'Neill, Miriam C. Poirier, Donald Putman, Paul T. Strickland, Jerry R. Williams, Shuqin Xiao
Journal: Environmental Health Perspectives (1993)

Using a multidisciplinary approach, we have measured various indicators of DNA damage in peripheral lymphocytes of human populations potentially at increased risk for cancer.Sister chromatid exchanges (SCE) and polycyclic aromatic hydrocarbon (PAH)-DNA adducts were evaluated in a group offirefighters; chromoso- mal aberrations and hprt mutations were evaluated in a group of cancer patients undergoing radieimmunoglobulin therapy (RIT); SCE and acrolein-modified DNA were measured in cancer chemotherapy patients and in pharmacists preparing chemotherapy prescriptions; and SCE and PAlH-DNA adducts are being measured in U.S. army troops stationed in Kuwait.Our results indicate that both SCE and PAH-DNA adduct levels were not elevated in firefighters, but that other factors such as smoking status and race were risk factors for increased SCE and PAH-DNA adducts.RIT was found to increase background rates of chromosome-type aberrations and frequencies of hprt mutations and there was a strong correlation between levels of therapy- induced chromosome damage sustained in vivo and in vitro sensitivity to radiation-induced chromosome damage.Peripheral blood lymphocytes of cancer patients treated with cyclophosphamide showed higher levels of SCE and had a higher incidence of acrolein adducts in DNA.Lymphocytes from pharmacists preparing antineoplastic drugs were found to acquire increased in vitro sensitivity to SCE induction by phosphoramide mustard with increased lifetime duration of drug handling.A prospective, longitudinal study was performed to identify environmental factors that modulate genetic damage in breast cancer patients.Women with benign breast masses and no apparent disease served as controls.Mutant frequency, cloning efficiency, and chromoso- mal aberration frequency did not differ significantly among the three groups.The results described and the data being gathered on troops stationed in Kuwait suggest that all the methodologies described can be useful in screening human populations for mutagenic exposures.
An expanding populace in a contracting world
Authors: M. H. Merrill
Journal: JAMA (1966)

In approaching the topic of this discussion, it is essential that we first accept the complexity of the population problem. We must try to see its interrelationship to many as yet unsolved problems —employment, education, health services, transportation, migration, housing, industrialization, agricultural productivity, increasing per capita income—to mention only a few. Other participants will deal with specific aspects of the problem. My purpose is to present an overview of an expanding world population and its relationship to national interests. In dealing with this subject, it is also essential that we keep in mind that as we work toward the solution of population problems our focus should be the individual. The focus cannot be to reduce, increase or stablize numbers of people. It must be to help make possible a richer, fuller life—jobs, homes, resources; freedom from hunger, disease, and ignorance; time for development of innate capacities—in short, enriching the quality
Occurrence and Transformation of Arsenic in the Marine Environment
Authors: G. Lunde
Journal: Environmental Health Perspectives (1977)

Among the trace elements, arsenic appears to possess a unique position in the environment. When comparing terrestrial and marine organisms there seems to be a significant difference between both level and chemical forms of arsenic. The level of arsenic in terrestrial organisms is seldom above 1 ppm (dry material) whereas the corresponding values for marine organisms vary from several parts per million up to more than 100 ppm. Furthermore, results so far show that marine organisms are able to convert inorganic arsenic into organic arsenic compounds. No evidence points to a corresponding ability in the terrestrial ones. In the aquatic organisms the arsenic is present as both lipid soluble and water soluble compounds. The water-soluble organic arsenic compounds have a basic character and are very stable to chemical and metabolic breakdown.
MAGAZINES FOR THE WAITING ROOM
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Nicholas S. Scarcello
Journal: New England Journal of Medicine (1955)

DEATHUssher — Clarence D. Ussher, M.D., died on September 20, in Santa Monica, California. He was in his eighty-sixth year.Dr. Ussher received his degree from the University Medical College of Kansas City in 1896.He is survived by his widow, one daughter and three sons.SOCIAL SECURITY —THE BIG ISSUE To the Secretary: Coming is the biggest issue to face the medical profession since the defeat of socialized medicine: the extension of compulsory social security.Although the American Medical Association has done all in its power to defeat this issue, and has been successful to date, we find . . .
The Sex Factor in Human Life. A Study Outline for College Men.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal