tbuckley/cabot-search huggingface dataset:
A phase II multi-institutional study to evaluate gemcitabine and fractionated stereotactic body radiotherapy for unresectable, locally advanced pancreatic adenocarcinoma.
Authors: Joseph M. Herman, Daniel Tandel Chang, Karyn A. Goodman, Aaron Tyler Wild, Dan Laheru, Lei Zheng, Luis A. Diaz, Dung Thi Le, Siva P Raman, Jeffrey P Leal, Muhammad Ali Chaudhry, Elizabeth Sugar, Laurie Ann Columbo, Ashlyn Tom, Maneesha R Limaye, Barish H Edil, Katharine Oteiza, Amy Hacker-Prietz, Christopher Lee Wolfgang, Albert Koong
Journal: Journal of Clinical Oncology (2012)

4045 Background: Phase I/II studies with single-fraction (25 Gy) stereotactic body radiotherapy (SBRT) for pancreatic ductal adenocarcinoma (PDA) have shown local progression free survival (LPFS) rates of &gt;90%, but are limited by late GI toxicity and minimal tumor response. We performed a phase II multi-center trial of gemcitabine (GEM) and fractionated SBRT to determine if a high rate of LPFS with reduced toxicity could be achieved. Methods: After multidisciplinary review, 32 pts with locally advanced PDA received GEM in sequence with SBRT (6.6 Gy in 5 consecutive daily fractions, 33 Gy total). LPFS, metastasis free survival (MFS), and overall survival (OS) were measured from date of tissue diagnosis. Objective tumor response (OTR) was assessed by RECIST/PERCIST. EORTC QLQ-C30/PAN26 questionnaires were used to measure QOL. Results: Median f-up was 12 mos (range, 2-23). Mean age was 69.9 yrs (SD, 9.8) and 62% were male. Pts received a mean of 2.2 (SD, 1.0) GEM doses prior to SBRT and 8.3 (SD, 5.6) doses total. All pts completed SBRT. Median OS was 15.9 months (95% CI, 12.7-18.8). Stratification by CA19-9 &gt; or &lt; 90 at diagnosis yielded a hazard ratio of 6.2 for &gt; 90 (p=0.021). Median LPFS has not been reached and median MFS was 10.2 mos (95% CI, 2.9-17.5). LPFS rate at 1 year was 87%. OTR on CT was seen in 41%, while 41% had stable disease and 18% progressed. Tumor metabolic activity decreased in 17/18 patients with pre/post-SBRT PET available. Mean peak SUV was 4.0 pre-SBRT versus 2.4 post-SBRT (p=0.002). Median CA19-9 was reduced from 124.7 prior to SBRT to 43.9 afterwards. Acute toxicity included: grade 2 anorexia (37%), fatigue (28%), nausea (22%), abd pain (19%), weight loss (9%), diarrhea (3%); gr 3 nausea (9%); and gr 4 nausea (6%). Late gr ≥3 GI toxicity was seen in 9%. Mean QOL score 4 wks post-SBRT was similar to baseline (p=0.38). At 6 mos there was a trend towards improved QOL (p=0.07). Conclusions: Fractionated SBRT with GEM achieves high rates of LPFS and tumor response. Minimal grade ≥3 acute and late toxicity was observed. SBRT is more likely to benefit patients with Ca-19-9 &lt;90. A combination of SBRT with more aggressive chemotherapy may further improve outcomes.
A Synopsis of Medicine.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drugging OXPHOS Dependency in Cancer
Journal: Cancer Discovery (2019)

Researchers at The University of Texas MD Anderson Cancer Center in Houston are developing an inhibitor of oxidative phosphorylation, IACS-10759, that targets complex I of the mitochondrial electron transport chain. Ongoing early clinical studies indicate that IACS-10759 appears safe, tolerable, and active; the drug has also shown efficacy in mouse models of ibrutinib-resistant mantle cell lymphoma.
The 11th Report of the Human Renal Transplant Registry
Authors: None y
Journal: JAMA (1973)

This 11th Report from the Renal Transplant Registry updates and extends a profile view of the natural history of a renal transplant and, in addition, comments on selected topics that have become increasingly important since the last report.<sup>1</sup> The Renal Transplant Registry operates under sponsorship of the American College of Surgeons and receives funding from several cooperating institutes of the National Institutes of Health. The present registry and its advisory committee are direct descendants of the Kidney Transplant Registry founded in Boston in 1963 and capably operated there for several years by Drs. Joseph E. Murray and Benjamin A. Barnes. That the registry exists at all is testimony to the vision of these investigators and the cultivation by them of a spirit of cooperation and experience-sharing with other transplantors that has allowed accumulation of registry data over subsequent years. It is recognized that the 246 institutions that report to
Principles and Practice of Infectious Diseases
Authors: William A. Causey
Journal: JAMA (1985)

Soon after the appearance of the first edition of<i>Principles and Practice of Infectious Diseases</i>(PPID) in 1979, it became, in the opinion of most infectious disease specialists, the standard textbook of the field. In my reviews of the first edition, the only criticism of substance that I had was the two-volume format. With frequent use over the years, my objections to the two-volume format have grown. This frustrating and inconvenient flaw, along with a few other minor ones, has been corrected in the second edition. Despite the reduction to a single volume, the second edition of PPID has more words and illustrations than the first. The application of modern printing technology has made possible the production of a work of mammoth proportions (1,760 pages, including index) in a single volume that does not seem excessively bulky. The type is quite small, but the quality of printing is excellent, yielding
Voluntary Hospitals
Authors: G. W. Goodhart
Journal: BMJ (1941)

Even after decades of research and pharmaceutical development, cancer is still one of the most common causes of death in the western population and the management of cancer will remain a major challenge of medical research. One of the most common types of cancer is colorectal cancer (CRC). Prevention by detection of early-stage precursors is the most reliable method to prevent CRC development. In dependence of age, familial predisposition, and other risk factors the preventative routine screening for CRC by colonoscopy should be performed at least twice in intervals of about ten years. Although colonoscopy is a life-saving clinical examination reducing both incidence and mortality of CRC significantly, it has still a bad reputation in the population as an uncomfortable procedure with unpleasant side effects lasting sometimes over days to weeks. These effects are most likely caused by the bowel preparation before colonoscopy, which is crucial for a successful colonoscopy with high quality. Beside pain, bleeding and other rare but severe complications of colonoscopy, cleaning of the intestinal mucosa alters the gut microbiome significantly and consistently. Abdominal pain, cramps, diarrhea, nausea, bloating, and constipation are common adverse events which can continue to affect patients for days or even weeks after the procedure. In this multicenter, placebo controlled, double blind clinical trial, we investigated the effect of an intervention with a multispecies probiotic formulation for 30 days on the adverse events due to bowel preparation. We show that the treatment of participants with the multispecies probiotic formulation decreases the number of days with constipation significantly, and reduced pain, bloating, diarrhea, and general discomfort. 16S based amplicon analyses reveal recovery of administered probiotic strains from stool samples and differences in alpha diversity dynamics with higher variability in the probiotic group compared to the placebo group. In conclusion, the probiotic ameliorates the side effects after colonoscopy and might be an important supplement to increase acceptance of this life-saving preventative examination. Further, we present here for the first time that probiotic intervention of only 30 days affects alpha diversity parameters in stool samples.
Alice Ozy
Authors: James G. Ravin
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physical activity and risk of severe gastrointestinal hemorrhage in older persons
Authors: M. Pahor
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess whether regular physical activity is associated with a decreased risk of severe gastrointestinal hemorrhage (GIH) in older persons. <h3>Design.</h3> —Cohort study with 3 years of follow-up. <h3>Setting.</h3> —Three communities of the Established Populations for Epidemiologic Studies of the Elderly. <h3>Participants.</h3> —A total of 8205 persons aged 68 years or older, yielding 22 277 person-years of follow-up. <h3>Measurements.</h3> —The occurrence of severe GIH was defined as either a hospital discharge diagnosis of gastrointestinal bleeding associated with blood transfusion or death during the hospital stay or a nonhospital death with mention of GIH on the death certificate. Physical activity was measured by self-reported frequency of walking, gardening, or doing vigorous physical activity. Those participants doing the activity three times per week or more were compared with the remaining participants. Adjusted relative risks (RRs) of GIH were controlled for age, gender, body mass index, blood pressure, chronic conditions, number of hospital admissions in the past year, and number and types of drugs taken. <h3>Results.</h3> —Severe GIH occurred in 241 participants (rate, 10.8 per 1000 person-years). After adjusting for potential confounding variables, the RRs and 95% confidence intervals (CIs) for severe GIH associated with walking, gardening, and vigorous physical activity were 0.6 (0.4 to 0.8), 0.8 (0.5 to 1.1), and 0.7 (0.4 to 1.2), respectively. The RR associated with a summary variable for the three activities was 0.7 (95% CI, 0.5 to 0.9). These results were consistent after stratifying on health status and disability or by excluding those who were not mobile, ie, not able to walk half a mile or climb a flight of stairs. <h3>Conclusions.</h3> —Regular physical activity is associated with a decreased risk for severe GIH in older persons. (<i>JAMA</i>. 1994;272:595-599)
Eighth International Symposium of the Fundación Argentina de Endocrinologia (FAE)
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Eighth International Symposium of the Fundación Argentina de Endocrinologia (FAE) Get access JNCI: Journal of the National Cancer Institute, Volume 70, Issue 1, January 1983, Page 213, https://doi.org/10.1093/jnci/70.1.213-c Published: 01 January 1983
Aids to Microscopic Diagnosis (Bacterial and Parasitic Diseases).
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Updated Hodgkin's disease: B. Curability of localized disease
Authors: P. Rubin
Journal: JAMA (1973)

The ability of irradiation to cure localized Hodgkin's disease and lymphomas is beyond debate. The problem is to determine in which patients the apparently localized disease is truly confined to the nodal sites. The current controversy in therapeutic management of localized Hodgkin's disease with radiation is whether it is preferable to treat selected sites only, or most of the lymph nodes and lymphoid tissue on both sides of the diaphragm. An elaborate diagnostic work-up that includes pedal lymphangiography, laparotomy, splenectomy, biopsies of the lymph node and liver, scanning the bone and bone marrow, and biopsy of the bone marrow may yield information pertinent to this decision. Careful documentation of patterns of recurrence after utilizing various field arrangements and effective doses of radiation therapy is also important. The primary therapeutic decision in Hodgkin's disease rests on the oncologist's estimation of the difference between the initial clinical appearance of the extent of
Fibrinolytic Activity of Plasma after Meals Rich in Olive Oil
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Results of the PROFIT trial, a PROspective randomised placebo-controlled feasibility trial of Faecal mIcrobiota Transplantation in advanced cirrhosis
Authors: Charlotte Woodhouse, Lindsey Edwards, Benjamin H. Mullish, Victoria Kronsten, Thomas Tranah, Ane Zamalloa, Clare Flach, Abdel Douiri, Julian Marchesi, Vishal Patel, Simon Goldenberg, Debbie L. Shawcross
Journal: Journal of Hepatology (2020)
Thoughts on Being a Physician
Authors: William S. Fletcher
Journal: JAMA (1967)

A university is not a factory which takes in raw materials on one end and puts out nicely packaged, finished products on the other. It is a living, breathing group of people who constantly exchange ideas. It is this constant interchange of ideas which pushes back the frontiers of knowledge and understanding of that knowledge. The raw materials for such a system are bright, curious, young minds. These traits we know you have. We hope you will use them. We hope you will ask pertinent questions. We hope you will doubt conventional ways and look at problems from new points of view. We need you just as much as you need us. Those of us who have been in the fray for some time welcome you as enthusiastically as a military unit, pinned down by rifle fire, welcomes fresh, rested, well-trained reinforcements. Everyone in an ideal medical school is a
Otolaryngology—Head and Neck Surgery
Authors: John K. Niparko
Journal: JAMA (1995)

The recent otolaryngology literature documents advances in understanding several disorders of interest to all physicians. Approaches to head and neck cancer, vocal cord palsy, sinusitis, otitis media, and hearing impairment have been heavily scrutinized in recent publications. A survey of this literature reflects continued progress in further refining interventions and their indications and in assessing patient outcomes for these prevalent disorders. Our molecular understanding of head and neck cancer continues to evolve and promises new directions in treating these lesions. Surgical oncologists have traditionally relied on light microscopic assessment of margins to ensure complete excision of a carcinoma. However, rare cancer cells at the margins of resection or in cervical lymph nodes may escape detection. With the use of molecular techniques, 13 of 25 patients with head and neck squamous cell carcinoma were found to have neoplastic cells in at least one tumor margin deemed to be negative by light
Utilization of sexual health and pelvic floor physiotherapy services in Vancouver's Prostate Cancer Supportive Care (PCSC) Program.
Authors: Celestia S. Higano, Christine Zarowski, Marcy Dayan, Phil Pollock, Stacy Elliott, Monita Sundar, Sarah Mahovlich, Larry Goldenberg
Journal: Journal of Clinical Oncology (2016)

10108 Background: The Vancouver Prostate Centre established the PCSC in January 2013 to provide education (ED) and clinic (CLIN) services to men with prostate cancer and their partners. The program includes a dedicated sexual health clinician and physiotherapist with expertise in male pelvic floor anatomy and physiology. These services are available to patients (pts) without charge. We examined the use of the SH and PT services in the PCSC to better understand how the services are utilized. Methods: Pts who are newly diagnosed or within 6 months of surgery or radiation are offered a group ED session that focuses on sexual side effects of therapy and sexual rehabilitation. All pts/couples are eligible to meet for clinic appointments with the SH RN. Couples evaluated in the SH clinic are invited to attend quarterly Intimacy Workshops (IW). Pts who are about to undergo surgery or who have postoperative incontinence are offered attendance at a group ED session that explains the anatomy and techniques for minimizing urinary symptoms. Pts may also attend up to 3 visits with the PT clinician. We gathered data from PCSC logs, clinic schedules, and pt records to assess utilization of SH and PT services. Results: SH and PT ED sessions and CLIN were initiated in July and October 2013 respectively. 479 of 741 (65%) pts, median age 65 (42-92), participated in SH and 227 pts (37%), median age 66 (42-88), in PT modules respectively. 90% of pts in each module had had surgery; 10% were on ADT. Details of utilization of ED and CLIN components from both modules are shown below. There was a total of 1011 SH and 434 PT clinic visits. 38% of pts who were seen by SH were also seen by PT and 66% of those seen in PT were seen in SH. Conclusions: Sexual dysfunction and urinary incontinence can be significant problems, and often occur together. Compared to other optional services available in PCSC, SH and PT are the most utilized. Lack of qualified clinicians with expertise in these areas should be addressed. # pts attending SH PT ED 62 89 ED+CLIN 125 103 CLIN 292 85 IW 46* -- Total 479 277 *couples
Underperforming doctors: a postal survey of the Northern Deanery
Journal: BMJ (1998)

Objectives: To discover the perceived size of pool of doctors considered to be underperforming in general practice in the Northern Deanery and to discover whether these perceptions are based on formal assessments.Design: Postal questionnaire.Setting: Area covered by the Northern Deanery.Subjects: Seven health authority directors of primary care, seven secretaries of local medical committees, and 14 chief officers of community
CUTANEOUS PROTOTHECOSIS
Authors: P. W. MARS, A. R. RABHON, J. J. RlPPEY, L. AJELLO
Journal: British Journal of Dermatology (1971)

A case of human infection with Prototheca wickerhmii is described. The infection involved the skin and subcutaneous tissues of the forehead and scalp and the organism was demonstrated histologically and grown in culture. There is an early response to potassium iodide treatment but the final outcome is still uncertain.
Erratum: CCL19-CCR7–dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima
Authors: Mark Roufaiel, Eric Gracey, Allan Siu, Su-Ning Zhu, Andrew Lau, Hisham Ibrahim, Marwan Althagafi, Kelly Tai, Sharon J Hyduk, Kateryna O Cybulsky, Sherine Ensan, Angela Li, Rickvinder Besla, Henry M Becker, Haiyan Xiao, Sanjiv A Luther, Robert D Inman, Clinton S Robbins, Jenny Jongstra-Bilen, Myron I Cybulsky
Journal: Nature Immunology (2017)
Diagnostic Bronchoscopy.
Authors: Yoshihiro Nakamura, Masami Sato
Journal: Annals of Internal Medicine (1977)

Endoscopic technology has developed markedly with endobronchial ultrasonography (EBUS) having become dramatically widespread over the past 10 years. EBUS-guided transbronchial needle aspiration (EBUS-TBNA) has become an important modality for the mediastinal staging of lung cancer as well as mediastinoscopy. The combination of EBUS with a guide sheath( EBUS-GS) and virtual navigation systems, such as Bf-NAVI, LungPoint, superDimension/Bronchus system, is useful for diagnosis of small peripheral pulmonary lesions. Moreover, the ability to observe lesions has increased using picture enhancement developed by new methods such as autofluorescence imaging( AFI), narrow band imaging (NBI), and FUJI intelligent color enhancement( FICE). However, these modalities have limited value in detection of lung cancer and preneoplastic lesions. In recent years, the indications for AFI have widened and it can be now used for evaluation of tumor extension. Knowledge of these new technologies is certainly useful to allow their routine clinical use by respiratory surgeons. We will review these new technologies in this paper.