tbuckley/cabot-search huggingface dataset:
Mental Retardation
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two Gratitudes
Authors: Chris D. Adrian
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
William Harvey and the circulation
Authors: L. S. King
Journal: JAMA (1967)

The discovery of the circulation marked a turning point in the history of thought, and consequently, William Harvey will always hold a dominant place among the immortals of medical science. Yet, when we compare him with many figures of lesser prominence, biographical data are quite sparse and primary documents, on which all biography must ultimately rest, relatively scanty. A biographer, therefore, in portraying Harvey, must emphasize the relationships into which he entered, the people with whom he came in contact, and the events in which he participated. Sir Geoffrey Keynes, the outstanding authority on Sir Thomas Browne as well as on Harvey, has just published the<i>Life of William Harvey</i>,<sup>1</sup>which will long stand as the definitive biography. Perhaps a more appropriate title might have been "The Life and Times" of William Harvey. Keynes depicts Harvey in relation to his friends, professional colleagues, and patients; to his sovereigns James
Role of Airborne Lead in Increased Body Burden of Lead in Hartford Children
Authors: Martha L. Lepow, Leonard Bruckman, Robert A. Rubino, Steven Markowitz, Marybeth Gillette, Janet Kapish
Journal: Environmental Health Perspectives (1974)

The ingestion of airborne lead fallout is the mechanism responsible for increased lead body burdens found in 10 urban Connecticut children. The mean indoor lead levels found in housedust was 11,000 μg/g; highest concentrations occurred on windowsills and in floor dust. The mean lead content of Hartford street dirt was 1,200 μg/g; levels were highest near the street and next to the buildings. The mean lead concentration of hand samples taken from the subject children was 2,400 μg/g; the mean weight of hand samples was 11 mg. The concentration of lead in dirt and househould dust was high enough to theoretically result in excessive lead accumulation in young children who are putting their dusty, dirty hands in their mouths during play. While we believe that lead emitted from automobiles contributes significantly to air, dirt and dust lead levels the environmental impact of reducing or eliminating lead from gasoline is not yet completely understood.
Chronic ethanol effects on cellular immune responses to hepatitis B virus envelope protein: An immunologic mechanism for induction of persistent viral infection in alcoholics
Authors: M Geissler
Journal: Hepatology (1997)

Hepatitis B virus (HBV) is common in alcoholics and may result in chronic infection. Persistence of HBV infection could be partially caused by the effects of ethanol on the cellular and humoral immune response to viral structural proteins. The DNA-based immunization approach was used to experimentally assess the effects of chronic ethanol feeding on immune responses directed against the middle envelope protein (MHBs) of HBV. Mice were fed an ethanol or isocaloric, pair-fed control liquid diet for 8 weeks, followed by immunization with a plasmid construct containing the pre-S2/S gene that encodes for MHBs. Chronic ethanol consumption marginally reduced the levels of the antibody to hepatitis B surface proteins (anti-HBs) generated by the DNA-based immunization approach. Initially, cytotoxic lymphocyte (CTL) activity was higher in ethanol-fed mice but progressively declined following the second and third immunizations as compared with control mice. In addition, CTL and CD4+ T helper (TH) cells responded poorly to increasing concentrations of envelope protein and peptides in vitro with respect to generation of CTL activity and proliferative responses. Finally, proliferating CD4+ T cells derived from ethanol-fed animals had substantial changes in the levels of cytokines secreted into the culture supernatants as compared with control mice. These studies show that chronic ethanol consumption substantially alters the cellular immune responses to a human viral structural protein, and that these effects may contribute to the persistence of viral infection.
Cesarean Section
Authors: Max Bader
Journal: JAMA (1985)

<h3>To the Editor.—</h3> There is a serious discrepancy between the maternal mortality statistics cited by Dr Danforth<sup>1</sup>in his article on cesarean section and the statistics on maternal mortality published by the National Center for Health Statistics. Using the latter's data, maternal mortality from cesarean section must be much lower than one to two deaths per 1,000 procedures. In 1980, there were only 250 maternal deaths recorded for the entire United States, a rate of 6.9 per 100,000 live births. Given the 1980 cesarean section rate of 16.5%, even if all of those deaths had involved cesarean sections, the mortality would only be 4.21 per 10,000 procedures, or one in every 2,375. If only 100 of those deaths related to cesarean sections, the mortality would be closer to one in every 6,000 procedures. In Oregon and Washington, the maternal mortality rates were even lower than the US rate (Table). Their
Pulsatile Flow in Patients With a Novel Nonpulsatile Implantable Ventricular Assist Device
Authors: Evgenij V. Potapov, Matthias Loebe, Boris A. Nasseri, Hendryk Sinawski, Andreas Koster, Hermann Kuppe, George P. Noon, Michael E. DeBakey, Roland Hetzer
Journal: Circulation (2000)

Background —Ventricular assist devices (VADs) are an accepted therapy for patients with end-stage heart failure. The implantable devices that are available produce a pulsatile flow and are very large. In 6 patients, beginning in November 1998, we started to use the continuous-flow implantable DeBakey VAD device, which weighs 93 g. To detect the flow in peripheral vessels, we measured transcranial Doppler signals in patients after implantation. Methods and Results —Transcranial Doppler studies were performed with the MULTI-DOP X4 device with two 2-MHz probes (for the middle cranial arteries) in 4 patients for up to 12 weeks twice weekly after implantation. The blood velocity was measured, and the pulsation index (PI) calculated. The measured pump flow and rotations per minute were registered. The preoperative echocardiographic assessment values were compared with those acquired 6 weeks after implantation. The PI increased continually in all patients after VAD implantation, left ventricular (LV) ejection fraction did not improve, but right ventricular (RV) ejection fraction after implantation improved compared with preoperative values. The LV end-diastolic diameter after implantation decreased between 11% and 46% intraindividually. There was no correlation between PI and blood pressure or, except in 1 patient, between PI and blood flow through the VAD. Conclusions —The DeBakey VAD unloads the LV, which leads to a decrease in LV end-diastolic LV diameter and to the restoration of RV function. The unloaded LV and partially recovered RV provide a nearly physiological pulsatile flow despite the continuous flow of the VAD. Pulsatility is independent of peripheral vascular resistance. The first clinical experience with the DeBakey VAD was positive and has resulted in its continued use.
Rejoinder
Authors: Louis Lasagna
Journal: JAMA (1975)

<h3>To the Editor.—</h3> I should like to respond to Goldberg's rebuttal (232:143, 1975) to our commentary, "The FDA, Politics, and the Public" (232:141, 1975). To begin with, Wardell and I are certainly<i>not</i>arguing that the Food and Drug Administration (FDA) should approve labeling for uses of new drugs as soon as these uses gain acceptance in current medical practice and in the literature. As Goldberg recognizes in some of the quotations attributed to me, I do not believe that there is a necessary relationship between actual and optimal clinical usage. Where Goldberg and I disagree, however, is in regard to what is "substantial evidence," who is to decide what<i>is</i>substantial evidence, and whether such substantial evidence exists for the use of propranolol in anginal patients. Distinguished and experienced clinicians all over the world have been impressed not only by the available literature on the use of propranolol in
St. Bartholomew's Hospital
Authors: S. Gee, D. Duckworth, T. L. Brunton, N. Moore, S. West, J. Langton, H. Cripps, W. B. Clarke, A. Bowlby, C. B. Lockwood, J. A. Ormerod, W. P. Herringham, H. H. Tooth, A. E. Garrod, J. Calvert, F. H. Champneys, W. S. A. Griffith, D. Power, H. J. Waring, W. M. Eccles, R. C. Bailey, W. D. Harmer, W. H. H. Jessop, T. H. Spicer, A. E. Cumberbatch
Journal: BMJ (1904)
Industries Where Smokeless Tobacco Use Is Highest
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Extrinsically induced arrhythmia in acute myocardial infarction
Authors: L. Gross
Journal: JAMA (1974)

Sixty patients with acute myocardial infarction (AMI) and 40 control subjects were monitored for arrhythmias after swallowing 170 ml (6 fl oz) each of hot and cold water. In 16 AMI patients, slowing of cardiac rate or premature ventricular contractions developed after ingestion of hot water. In one patient, ventricular tachycardia appeared after both types of drinks. None of the control patients manifested arrhythmias. Ten of the 16 AMI patients were pretreated with 0.8 mg of atropine sulfate administered intravenously; no arrhythmias developed after drinking hot water. Patients with acute myocardial infarction should avoid hot beverages. (<i>JAMA</i>228:1021-1024, 1974)
Phase II study of RAD001 (Everolimus) in previously treated small cell lung cancer (SCLC)
Authors: T. K. Owonikoko, R. G. Stoller, D. Petro, R. Flaugh, P. A. Hershberger, C. P. Belani, A. E. Argiris
Journal: Journal of Clinical Oncology (2008)

19017 Background: The mammalian Target of Rapamycin (mTOR) plays a central role in the PI3K/AKT signaling pathway, which may be important in the proliferative and antiapoptotic signaling in SCLC. RAD001 is an orally administered mTOR inhibitor with dose-dependent in vitro activity in SCLC cell lines and potent in vivo growth inhibition in xenograft models. Methods: Eligible patients (pts) had pathologically documented SCLC that relapsed after 1–2 prior chemotherapy regimens, ECOG performance status (PS) 0–2, and adequate bone marrow, kidney and liver function. Pts with untreated or symptomatic brain metastasis were excluded. RAD001 was administered orally continuously at a daily dose of 10 mg until disease progression or unacceptable toxicity. A cycle was 3 weeks with response assessment after every 2 cycles. The primary endpoint was the disease non-progression rate. Using a 2-stage design, 21 pts will be enrolled in the first stage. If ≥7 pts show disease stability or response, 21 additional pts will be accrued in the second stage. PI3K/AKT signaling pathway proteins (PTEN, AKT, pAKT, p-S6, p-4E-BP1) expression will be assessed by immunohistochemistry in baseline tumor tissue and will be correlated with response. Results: 17 pts have been enrolled: median age- 63 years (44 - 80); males- 6 (35%); PS0- 35%; PS1- 65%. Prior chemotherapy: Platinum/etoposide: 17 (100%), 2nd line- 2 (12%); prior radiation: chest- 8/17 (47%); brain- 9/17 (53%). 11 pts had sensitive relapses (i.e. >60 days from first-line chemotherapy completion). 1 pt did not complete the first cycle of RAD001, 5 received 1 cycle, and 10 (59%) ≥2 cycles; number of days on treatment: median- 42 days (3−117+). In 16 evaluable pts, there were no objective responses; 3 pts had stable disease (19%) as best response while 13 pts had progressive disease (81%). Duration of stable disease: 69 - 117+ days. No grade 3 or 4 toxicities were encountered. Grade 2 toxicities were as follows: fatigue (4), thrombocytopenia (3), elevated transaminases (2), anemia (2), rash (2), hypertriglyceridemia (1), and hypermagnesemia (1). Conclusions: Preliminary results show that RAD001 is well tolerated but has low activity as a single agent in unselected, previously treated pts with SCLC. Updated results and biomarker analysis will be available for presentation. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Novartis
THE CONGENIAL CALORIES OF THE CANDY SHOP
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scanned
Authors: Stanley Cohen
Journal: Annals of Internal Medicine (2016)

Ad Libitum5 April 2016ScannedStanley Cohen, MDStanley Cohen, MDFrom Atlanta, Georgia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-2107 Audio Reading - “Scanned” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Scanned," by S. Cohen. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail You see, I wear readers now,(sometimes) to scan through denserecords that list your everymedication, whether they oftensat in the cupboard or actuallywere taken, though I don't need themto magnify the horrors your life'sbeen, and the scars you bare.You sit patiently on the almostburgundy padding, waiting forthe freezing bell on your chest,the tubes connecting directlyto my ear, though I listen mostlyto hear your humanity, and mydull fingers do little more thanfeel edges and ripening melons.probes ... Author, Article, and Disclosure InformationAffiliations: From Atlanta, Georgia.Current Author Address: Stanley Cohen, MD, Children's Center for Digestive Health Care, 993D Johnson Ferry Road, #440, Atlanta, GA 30342; e-mail, [email protected]rkids.com. PreviousarticleNextarticle Advertisement Audio Reading - “Scanned” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Scanned," by S. Cohen. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 5 April 2016Volume 164, Issue 7Page: 502KeywordsBacteriaChild healthChildrenHealth careLiverScarsThorax ePublished: 5 April 2016 Issue Published: 5 April 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
HIGH DEGREE ATRIOVENTRICULAR BLOCK, ASYSTOLE, AND ELECTRO-MECHANICAL DISSOCIATION COMPLICATING NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Sean Pokorney, Christina Radder, Phillip Schulte, Sana Al-Khatib, Pierluigi Tricoci, Frans Van de Werf, Stefan James, Christopher Cannon, Paul Armstrong, Harvey White, Robert Califf, C. Michael Gibson, Robert Giugliano, Lars Wallentin, Kenneth Mahaffey, Robert Harrington, L. Kristin Newby, Jonathan Piccini
Journal: Journal of the American College of Cardiology (2014)
Abstract A87: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function
Authors: Andrea Viale, Piergiorgio Pettazzoni, Costas Lyssiotis, Haoqiang Ying, Nora Sánchez, Matteo Marchesini, Alessandro Carugo, Tessa Green, Sahil Seth, Virginia Giuliani, Timothy Heffernan, Alec Kimmelman, Huamin Wang, Jason Fleming, Lewis Cantley, Ronald DePinho, Giulio Draetta
Journal: Cancer Research (2015)

Abstract This abstract is also being presented as a short talk in Session 7: New Therapies. A full abstract is printed in the Proffered Abstracts section (PR13) of the Conference Proceedings. Citation Format: Andrea Viale, Piergiorgio Pettazzoni, Costas Lyssiotis, Haoqiang Ying, Nora Sánchez, Matteo Marchesini, Alessandro Carugo, Tessa Green, Sahil Seth, Virginia Giuliani, Timothy Heffernan, Alec Kimmelman, Huamin Wang, Jason Fleming, Lewis Cantley, Ronald DePinho, Giulio Draetta. Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr A87.
Aluminum in Alzheimer's Disease
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal