tbuckley/cabot-search huggingface dataset:
Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin
Authors: N. Levine
Journal: JAMA (1991)

<h3>Objective.</h3> —To determine the efficacy of short-term administration of a synthetic analogue of α-melanotropin, [<i>N</i>le<sup>4</sup>D-Phe<sup>7</sup>] (NDP)—α-melanocyte-stimulating hormone (MSH), in darkening (tanning) human skin. <h3>Design.</h3> —Randomized, placebo-controlled, double-blind clinical trial. <h3>Setting.</h3> —Clinical research unit of a university medical center. <h3>Subjects.</h3> —Twenty-eight healthy white men with a history of either poor tanning (skin type I or II) or good tanning (skin type III or IV) recruited from advertisements and paid to participate in the study. <h3>Methods.</h3> —Each subject received 10 subcutaneous injections of either a purified NDP preparation or saline over 12 days. They were followed up for 7 weeks after therapy was completed. All subjects used a high-potency sunscreen during the the trial. <h3>Main Outcome Measure.</h3> —Skin darkening was quantified by serial chromaticity measurements prior to, during, and after therapy. <h3>Results.</h3> —A significant parabolic curve of skin darkening activity was noted in subjects with skin type I or II (<i>P</i>,.001) and with skin type III or IV (<i>P</i>&lt;&lt;.001) who were given NDP. No darkening occurred in the subjects who were given a placebo. Peak changes were seen 1 to 3 weeks after therapy was completed. <h3>Conclusion.</h3> —Human skin darkens as a response to a synthetic melanotropin given by subcutaneous injection. Skin tanning appears possible without potentially harmful exposure to ultraviolet radiation. (<i>JAMA</i>. 1991;266:2730-2736)
Treating Vaginal Trichomoniasis With Metronidazole
Journal: JAMA (1963)

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Incorrect Quote
Journal: JAMA (1983)

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A New Special Section in Endoscopy: Picture Gallery
Journal: Endoscopy (2003)

We are proud to introduce a new series directed at teaching us how to recognize early cancers and what methods to apply to characterize them further. Greatly influenced by the focus on imaging by our Japanese colleagues, endoscopists in the West are also shifting their main interest from detecting gross polypoid or ulcerous lesions to the recognition of flat and slightly elevated or depressed lesions, which may be smaller or larger. A variety of more sophisticated techniques to detect and characterize these lesions has been developed and welcomed enthusiastically all over the world. Furthermore, there is hope that endoscope manufacturers produce better instruments with better resolution and associated functions in order to highlight these early and subtle lesions. Nevertheless, continuous training of our eyes and cognitive abilities is necessary to increase our yield with current instruments.
The Letter
Journal: JAMA (1999)

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Endocrine exophthalmos. Humoral and orbital factors
Authors: H. M. Haddad
Journal: JAMA (1967)

This exhibit demonstrates the correlation between the clinical syndrome of endocrine exophthalmos and the responsible humoral and orbital factors. The management of the syndrome, both medical and surgical, is presented in the light of the various theories suggested for its pathogenesis. <h3>Clinical Manifestations</h3><h3>Proptosis.—</h3> Lid retraction with baring of the sclera or lid lag (Fig 1) may be the early manifestation of proptosis. One patient with pronounced proptosis had bilateral ptosis, with negative tensilon test clinically and by electromyography. Proptosis as demonstrated classically in the syndrome may be very pronounced (Fig 2). <h3>Motility Defect.—</h3> Most patients have insufficiency of convergence (Möbius sign). The patient often tilts the chin upwards in order to attain fusion (Fig 2). Diplopia, either horizontal (exotropia) or vertical (hypotropia) is mostly related to limitation of extraocular muscles, either of adduction or of upward gaze. A high secondary deviation (hypertropia) in the unaffected eye (Fig 3) may
The "acne" of tuberous sclerosis
Authors: K. M. Halprin
Journal: JAMA (1967)

The next patient you see with juvenile "acne" may have adenoma sebaceum—one of the manifestations of the inherited disease, tuberous sclerosis. This particular "acne" will be centrally clustered, dome-shaped instead of conical, rather vascular, will lack blackheads and pustules, and most importantly will occur in a child who is prepubertal and therefore too young to have true acne (Fig 1). These hamartomatous growths are composed of vascular, epithelial, glandular, and collagenous elements and have characteristic histologic elements. Mental retardation and seizures develop in most patients with tuberous sclerosis during early childhood. Some, however, do not show central-nervoussystem signs, and their condition, therefore, is not recognized before the appearance of their cutaneous lesions. Many adults with this disease lead normal lives and are not aware of the serious portent of their skin lesions. Unfortunately, there is no guarantee that cerebral calcifications, mental retardation, and all the manifestations of tuberous sclerosis will
Vascular ectasias of the right colon
Authors: S. Sprayregen
Journal: JAMA (1978)

VASCULAR ectasias of the right side of the colon (also referred to as angiodysplasias, arteriovenous malformations, and angiomas), are being recognized with increasing frequency as a cause of lower intestinal tract bleeding in the elderly.<sup>1,2</sup>In a recent review of the experience at Montefiore Hospital and Medical Center, New York, from 1971 through 1976, ectasias and diverticulosis were the commonest causes of lower intestinal hemorrhage in patients older than 65 years of age and were approximately equal in number. Clinically, patients with symptomatic ectasias usually present with multiple episodes of acute lower intestinal hemorrhage, which may appear as bright red or maroon bleeding or as melena. Less commonly, ectasias produce chronic blood loss and anemia requiring blood transfusions. Characteristically, colonic ectasias (1) occur mostly in patients older than 60 years of age, (2) are not associated with angiomatous lesions of the skin or other viscera, (3) almost always occur
Adult Jehovah's Witnesses and blood transfusions
Authors: Edwin J. Holman
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SANITARY MISCONCEPTIONS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autoantibodies may cause bronchospasm in adults
Authors: W. A. Check
Journal: JAMA (1980)

Scientists have opened up a possible new approach to understanding bronchospasm in asthma sufferers with the finding that many patients with airway obstruction have substantial amounts of antibody to the receptor that, when bound to epinephrine, produces bronchial relaxation. The search for such autoantibodies became possible when the cell receptor involved, the β<sub>2</sub>-adrenergic receptor, was purified in the laboratory of J. Craig Venter, PhD, of the Department of Pharmacology and Therapeutics at the State University of New York at Buffalo. In healthy persons, epinephrine binding to the β<sub>2</sub>-adrenergic receptor causes bronchial smooth muscle to relax. However, in persons with asthma, according to one prevailing theory, bronchospasm may occur because these receptors are less sensitive to epinephrine. Venter and colleagues reasoned that this loss of sensitivity might be caused in some persons by antibodies to the receptor, just as myasthenia gravis is most likely caused by antibodies
Clinical Lectures on Dislocations, Delivered at the Charing - Cross Hospital
Authors: H. Hancock
Journal: BMJ (1845)

LECTURB XIY.Gentlemen,-I now propose to consider the general treatment of dislocatioti, and subsequently describe the individud methods which have from time to time ben enmployed, since, as Petit has remarked, " Although e*a rgeon prefers the method with which he has m "et freqjuently succeeded, to all others, still every one know.that we are not always succesful, and that eten the best appaatus will sometimes fail."No one subject in the whole catalogue of surgery opose fuly confirua the axiom of Solomon, that " there isneting new under the aun," thas the one under
Organizing and Delivering Health Care—Part 3
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pursuit of Excellence— Through Continuing Medical Education
Journal: JAMA (1969)

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Insulin zur Einführung in die Insulintherapie des Diabetes mellitus.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Authors’ Reply
Authors: Julian C. Hong, Joseph K. Salama
Journal: Journal of the National Comprehensive Cancer Network (2019)

We read with interest the study by Hong et al 1 on stage migration in small cell lung cancer (SCLC) after increased FDG-PET use.The authors postulate that this led to improved survival because appropriate treatment was delivered due to accurate staging provided by FDG-PET.The authors should be commended for reporting data from a large retrospective cohort.However, as they acknowledged, there are many confounders and selection biases in this study that limit the ability to draw firm conclusions.For this reason, their findings do not provide sufficient evidence to support the routine clinical use of FDG-PET/CT in SCLC.The survival improvement reported over the course of the study could be due to improvements in supportive care or chemoradiotherapy delivery techniques, both unaccounted for in their analysis.Hong et al compare their outcomes to those of the CONVERT trial, 2 in which 57% of patients were staged with FDG-PET/CT in addition to conventional imaging (thorax/ abdomen CT, brain imaging 6 bone scintigraphy).We would like to note our re-
THE MAYBRICK CASE.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peptide Receptor Radionuclide Therapy
Authors: J. J. M. Teunissen, D. J. Kwekkeboom, M. de Jong, J. -P. Esser, R. Valkema, E. P. Krenning
Journal: Clinical Nuclear Medicine (2007)

This chapter is based on an earlier article with the same title and by the same authors which appeared in Best Practice & Research: Clinical Gastroenterology, August 2005
Empirical therapy for the management of acute proctitis in homosexual men
Authors: A. M. Rompalo
Journal: JAMA (1988)

An effective empirical treatment regimen would provide a more rapid and less expensive approach to the management of homosexual men with acute proctitis. We conducted a randomized trial in 129 homosexual men who presented with acute proctitis, comparing treatment with an empirical regimen (4.8 million U of aqueous penicillin G procaine intramuscularly and 1.0 g of probenecid orally, followed by 100 mg of oral doxycycline twice daily for seven days) with specific therapy for each infection as it was recognized. Therapy with the empirical regimen resulted in more rapid resolution of the symptoms of proctitis, the objective signs of proctitis, and the infecting microorganisms. However, nearly one fourth of the patients, primarily those with unrecognized herpes simplex virus proctitis, did not respond to empirical therapy. We recommend empirical therapy coupled with appropriate pretreatment diagnostic testing for the initial management of acute proctitis in homosexual men with no clinical evidence of acquired immunodeficiency syndrome or AIDS-related complex. (<i>JAMA</i>1988;260:348-353)
Relationship Between p53 Mutations and Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer
Authors: S. Ambs, W. P. Bennett, W. G. Merriam, M. O. Ogunfusika, S. M. Oser, A. M. Harrington, P. G. Shields, E. Felley-Bosco, S. P. Hussain, C. C. Harris
Journal: JNCI Journal of the National Cancer Institute (1999)
Reduced Thalamic Volume in Patients With Chronic Schizophrenia After Switching From Typical Antipsychotic Medications to Olanzapine
Authors: Babak Khorram
Journal: American Journal of Psychiatry (2006)

Objective: The authors performed a longitudinal study of the effects on thalamic volume of switching from typical to atypical antipsychotic medications. Method: Magnetic resonance imaging scans were acquired from 10 subjects with chronic schizophrenia taking typical antipsychotics and 20 healthy volunteers. Subjects with schizophrenia were switched to olanzapine; both groups were rescanned. Results: At baseline, thalamic volumes in subjects with chronic schizophrenia were 5.8% greater than those of healthy volunteers. At follow-up, there was no significant difference between groups. Additional analysis revealed a significant positive correlation between baseline thalamic volume and dosage of typical antipsychotic medication. Higher dosages at baseline were correlated with larger reductions in volume after the switch to olanzapine. Conclusions: Antipsychotic medication effects may be a factor in the wide range of thalamic volume differences reported between subjects with schizophrenia and healthy volunteers.