tbuckley/cabot-search huggingface dataset:
CAFFEINE.
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preliminary results of phase II trial of concomitant administration of intra-vesical reduced dose Bacillus Calmette- Guerin (BCG) and interferon a 2B (IFN) in the prevention of recurrence of superficial bladder cancer
Authors: S. Bazarbashi, M. Raja, S. Kattan, M. Rahal, A. El-Weshi, C. Pai, K. Rehman, M. Aslam, K. Othman, K. Hanash
Journal: Journal of Clinical Oncology (2004)

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Misclassification of Bronchioloalveolar Carcinoma with Cytologic Diagnosis of Lung Cancer
Authors: Dan J. Raz, Jason A. Zell, Anthony N. Karnezis, Anobel Odisho, S H. Ignatius Ou, Hoda Anton-Culver, David M. Jablons
Journal: Journal of Thoracic Oncology (2006)
SOME FEATURES OF ABDOMINAL SURGERY AT PHILADELPHIA.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SMOKE NUISANCE; A FABLE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preface
Journal: Liver Cancer (2021)

Liver cancers are complex neoplastic diseases with varied etiologies. Despite numerous research programs and clinical trials targeting several molecules in the last 50 years, hepatocellular carcinoma, the most common form of liver cancer, is still difficult to cure, and has become the second most common cause of cancer-related deaths in adults. This, at least in part, is due to the rising incidence of obesity, non-alcoholic fatty liver diseases, and excessive alcohol consumption. An adequate knowledge of the disease, including its etiology and pathology, is essential to develop effective therapies. Contributed by some of the leading hepatologists and pathologists in the field, this book is an effort to provide students, basic scientists, clinicians, and pathologists with a comprehensive understanding of the pathology, diagnosis, treatment, and management of various types of liver cancers. There are nine chapters in the book. Chapter 1 provides a comprehensive review of malignant epithelial tumors of the liver in children and adolescents. Hepatocellular carcinoma, lipid-rich hepatocellular carcinoma, fibrolamellar carcinoma, and cholangiocellular carcinoma are discussed. CONTINUE READING.....
The case against tenure in medical schools
Authors: R. G. Petersdorf
Journal: JAMA (1984)

TENURE in medical schools is a relatively new phenomenon. It developed slowly, primarily because most medical schools consisted of parttime faculty until World War II. These part-time faculty were primarily clinicians who derived most of their income from the practice of medicine and were not dependent on the university for their economic survival. Although a number of medical schools had small basic science departments, even in them, tenure was not a subject of contention. Tenure developed in medical schools primarily as the medical schools became a progressively integral part of the university. It developed a much stronger base in public medical schools than in private medical schools, but was accepted even by the private schools, primarily to place them in a competitive position in the recruitment and retention of faculty and to provide employment security. The purposes of tenure are well known. It exists to protect faculty from adverse outside
Assessment of Short-term Anticoagulant Administration after Cardiac Infarction
Journal: BMJ (1969)

This report describes the design and results of a controlled trial of anticoagulant drugs in the treatment of patients admitted to hospital suffering from acute myocardial infarction. A total of 1,427 patients were allocated at random to therapy with high-dosage or low-dosage anticoagulants. The high-dosage regimen was 36 hours of heparin administration and phenindione in doses to maintain the thrombotest level between 10 and 20%. The mean phenindione dosage was 72 mg./day. The low-dosage regimen consisted of 1-mg. tablets of phenindione. Therapy was continued for 28 days. There was no significant reduction in the mortality in the high-dosage group. Among the 712 patients allocated to high dosage 115 (16·2%) died before the 29th day of the trial. Of the 715 patients allocated to low dosage 129 (18%) died. This difference between these mortality rates could have occurred by chance. There was a significant reduction in the frequency of clinically evident thromboembolic complications (systemic artery occlusion, leg vein thrombosis, and pulmonary embolism) among patients in the high-dosage group. This did not, however, materially affect the difference in mortality from all causes.
Old human centrifuge: forebear of new scanner
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How Operant Conditioning Can Contribute to Behavioral Toxicology
Authors: Victor G. Laties
Journal: Environmental Health Perspectives (1978)

Operant conditioning can contribute to the development of behavioral toxicology in many ways. Its techniques are useful in training animals in the various behaviors the toxicologist may wish to study. They make possible the sophisticated assessment of sensory functioning. Operant conditioners excel at using schedules of intermittent reinforcement to create the type of stable animal performance needed in studying substances that produce effects only after prolonged exposure. Schedule-controlled behavior also helps elucidate the precise behavioral mechanisms involved in toxicity. In the early assessment of toxic substances a judiciously chosen sample of schelule-controlled performances may provide the best estimate whether the integrity of complex operant behavior remains unchanged. The development of improved behavioral techniques and computer technology promises to bring down the cost of such assessment.
Nephrology
Authors: Ram Duarte
Journal: JAMA (1985)

No matter what one's level of expertise in nephrology, a complete, clear, precise, and concise discussion of pertinent aspects of the subspecialty is always necessary, although frequently elusive. In<i>Nephrology</i>the editors have achieved such expression by capturing the essence of recent scientific discoveries and elegantly transforming them into readable and not easily forgettable didactic material. The various discussions contained in these proceedings of the IX International Congress on Nephrology have been well divided, organized, and presented. Most important, from beginning to end, all the chapters lead the reader from the basic physiological concepts to clinically relevant conditions; a gap frequently hard to bridge. In volume 1, I particularly enjoyed the clarity with which several complicated topics, such as electrolyte transport, tubuloglomerular feedback, and the renin-angiotensin and other hormonal systems, were presented. The updated discussions on acute renal failure, the effects of nonsteroidal anti-inflammatory agents, and sodium handling in various
PREDICTED AND UNPREDICTED CROSS-REACTIONS OF AN ACETYLPHOSPHOGALACTAN OF SPOROBOLOMYCES YEAST
Authors: Michael Heidelberger, Morey E. Slodki
Journal: The Journal of Experimental Medicine (1968)

The teichoic acid of streptococcal Group N, with end groups of galactose phosphate, had been shown to cross-react with antipneumococcal sera of types VI, XIV, XVI, and XXVII. End groups of D-galactose-1-phosphate in the phosphogalactans of Sporobolomyces yeasts made it predictable that these galactans would precipitate the same antipneumococcal sera and also antisera to streptococcal Group N. The predictions were verified, and other unpredicted reactions were found. Precipitation of much of the antibody in an antipneumoccal type XVIII horse serum was shown to be due to O-acetyl-D-galactose residues in the phosphogalactan, in accord with earlier information that an O-acetyl sugar was a principal determinant of S XVIII. The new results identify this sugar as D-galactose. Since it is linked 1,3- in S XVIII, the O-acetyl group in the Sporobolomyces galactan is probably also on a 1,3-linked residue. Another major cross-reaction in anti-S. paratyphi A serum characterizes the galactose residues in the "O" polysaccharide of the bacillus as members of the D-series probably linked in tandem 1,6-, 1,6-; 1,6-, 1,3-; 1,3-, 1,6-; or 1,3-, 1,3-. Reactions of periodate-oxidized-reduced products confirm the conclusions stated above. Quantitative data are given.
THE NEW YORK OSTEOPATHY BILL.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1957)

COMMITTEE ON MATERNAL WELFARESevere Pre-eclampsiaA twenty-one-year-old gravida 1 was first seen in the clinic when twenty weeks pregnant, with normal findings except for a 7.3-kg. (16-pound) weight gain to 51.7 kg. (114 pounds). At the next visit, over six weeks later, she had gained 6.4 kg. (14 pounds) more, but the blood pressure and urine were normal. She had no symptoms.She was not seen again until more than a month later, when an additional gain of 9.5 kg. (21 pounds) was found, — total gain, 23.1 kg. (51 pounds), — as well as marked peripheral edema, a . . .
Using speed of ageing and “microlives” to communicate the effects of lifetime habits and environment
Journal: BMJ (2012)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Using speed of ageing and “microlives” to communicate the effects of lifetime habits and environment Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Successful treatment of steroid and cyclophosphamide-resistant hemolysis in chronic lymphocytic leukemia with rituximab
Authors: Jens Chemnitz, Andreas Draube, Volker Diehl, Jürgen Wolf
Journal: American Journal of Hematology (2002)

The role of angiogenesis for the progressive growth and metastatic process of tumours is well established. What is not clear, though, is the clinical prognostic significance of the angiogenic factors in malignant haematological diseases. In this study, we have assessed the plasma and serum levels of two major angiogenic factors, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF) in 55 patients affected by chronic myeloproliferative disorders (CMD). This series included 25 patients with essential thrombocythemia (ET), 10 patients with chronic myelocytic leukaemia (CML), 14 patients with polycythemia vera (PV), and 6 patients with primary myelofibrosis (MF), and they were compared to 20 healthy control subjects. In all patients the plasma VEGF concentration was significantly increased to the healthy control group (P < 0.004). The highest concentrations were found in the patients with ET (178.25 ± 125.22 pg/ml). The VEGF levels were significantly higher in CMD patients with vascular complications than those in CMD patients without complications (P < 0.01). The b-FGF serum levels also appeared to be significantly higher in almost all the CMD patients compared to the control group (P < 0.07). A significant correlation was found between the VEGF levels and the platelet count in the ET patients and the spleen index in the CML patients. VEGF level, in this study, is associated with increased risk of thrombotic complications. There is evidence of increased levels of soluble angiogenic factors in malignant haematological disorders, but their contribution to the progression of diseases is yet unclear. Am. J. Hematol. 69:159–163, 2002. © 2002 Wiley-Liss, Inc.
TYMPANIC THERMOMETRY
Authors: CHARLES J. ZERZAN
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 November 1969TYMPANIC THERMOMETRYCHARLES J. ZERZAN JR., M.D.CHARLES J. ZERZAN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-5-1025_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The excellent article "Mechanims for Inefficient Peritoneal Dialysis in Acute Renal Failure Associated with Heat Stress and Exercise" by Nolph and co-workers (Ann. Intern. Med., 71: 317, 1969) offers further basic information in clarifying the advantages and disadvantages of two related procedures (that is, hemo- and peritoneal dialysis).The authors note in Table 1 that "Unfortunately, we were unable to determine whether these temperatures on initial examination were oral or rectal." As reported by Theodore Benzinger inJAMA209: 1200, 1969, and Maria Benzinger inJAMA209: 1207, 1969, both rectal and oral temperatures are inconsistent, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES J. ZERZANJR., M.D.Affiliations: University of Oregon Medical School 3181 S.W. Sam Jackson Park Road Portland, Ore. 97201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1969Volume 71, Issue 5_Part_1Page: 1025-1025KeywordsAcute renal failureExercisePeritoneal dialysisTemperature ePublished: 1 December 2008 Issue Published: 1 November 1969 PDF downloadLoading ...
NSABP B-59/GBG 96-GeparDouze: A randomized double-blind phase III clinical trial of neoadjuvant chemotherapy (NAC) with atezolizumab or placebo in patients (pts) with triple-negative breast cancer (TNBC) followed by adjuvant atezolizumab or placebo.
Authors: Charles E. Geyer, Sibylle Loibl, Priya Rastogi, Sabine Seiler, Joseph P. Costantino, Valentina Nekljudova, Patricia Cortazar, Peter C. Lucas, Carsten Denkert, Eleftherios P. Mamounas, Christian Jackisch, Norman Wolmark
Journal: Journal of Clinical Oncology (2019)

TPS605 Background: TNBC is associated with higher percentages of pathological complete response (pCR) to neoadjuvant chemotherapy (NAC), and women with a pCR have a favorable prognosis. However, Liedtke (2008) and Loibl (2017) found that women with residual disease have a substantially higher risk of recurrence than women with other subtypes of breast cancer. Additionally, Adams (2017) and Schmid (2017) found that therapeutic blockade of PD-L1 binding by atezolizumab has resulted in relevant anti-tumor efficacy. Methods: Design: This is a phase III, double blind, placebo-control trial evaluating neoadjuvant atezolizumab with NAC followed by adjuvant atezolizumab in TNBC. Pts are stratified by region (North America; Europe), tumor size (1.1-3.0cm; &gt;3.0cm), AC/EC schedule (q2w; q3w), nodal status (positive; negative), and PD-L1 status (positive; negative or indeterminate) then randomized 1:1 to receive atezolizumab/placebo 1200 mg IV every 3 wks concurrently with both sequential regimens of weekly paclitaxel 80 mg/m 2 IV for 12 doses with every 3-wk carboplatin AUC of 5 IV for 4 doses followed by AC/EC every 2-3 wks (per investigator discretion) for 4 cycles. Following surgery, pts resume atezolizumab/placebo 1200 mg IV every 3 wks as adjuvant therapy for 6 months. Radiotherapy based on local standards is co-administered with atezolizumab/placebo. Eligibility criteria: Centrally confirmed ER-neg, PR-neg, HER2-neg invasive breast cancer by ASCO/CAP guidelines. Primary tumor must be stage T2 or T3 if cN0 or cN1 with negative biopsy or T1c, T2, or T3 if cN1 with positive biopsy or cN2 or cN3. LVEF &gt;55% and no significant cardiac history. Statistical methods: Co-primary endpoints are event-free survival (EFS) and pCR breast/nodes. Secondary endpoints include pCR breast, overall survival, distant disease-free survival, safety and toxicity. Trial is an academic collaboration between NSABP and GBG with support from Genentech/Roche. Support: Genentech/Roche. Clinical trial information: NCT03281954.
Presidential Disability and the Twenty-fifth Amendment-Reply
Authors: Arthur S. Link
Journal: JAMA (1995)

<h3>In Reply.</h3> —Dr Toole and I agree, for the most part, with the letters concerning the discussion and comments on presidential disability. Certainly, the most difficult form of disability is dementia and loss of full cognitive powers, in part because such disease can be very difficult to diagnose in its early stages. Also, we agree with Dr Lee's assertion that a main objective is to find some way to strengthen the position of the physician to the president.