tbuckley/cabot-search huggingface dataset:
High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy
Authors: David-Alexandre Gross, Stéphanie Graff-Dubois, Paule Opolon, Sébastien Cornet, Pedro Alves, Annelise Bennaceur-Griscelli, Olivier Faure, Philippe Guillaume, Hüseyin Firat, Salem Chouaib, François A. Lemonnier, Jean Davoust, Isabelle Miconnet, Robert H. Vonderheide, Kostas Kosmatopoulos
Journal: Journal of Clinical Investigation (2004)

Most of the human tumor-associated antigens (TAAs) characterized thus far are derived from nonmutated “self”-proteins. Numerous strategies have been developed to break tolerance to TAAs, combining various forms of antigens with different vectors and adjuvants. However, no study has yet determined how to select epitopes within a given TAA to induce the highest antitumor effector response. We addressed this question by evaluating in HLA-A*0201-transgenic HHD mice the antitumor vaccination efficacy of high- and low-affinity epitopes from the naturally expressed murine telomerase reverse transcriptase (mTERT). Immunity against low-affinity epitopes was induced with heteroclitical variants. We show here that the CTL repertoire against high-affinity epitopes is partially tolerized, while that against low-affinity epitopes is composed of frequent CTLs with high avidity. The high-affinity p797 and p545 mTERT epitopes are not able to protect mice from a lethal challenge with the mTERT-expressing EL4-HHD tumor. In contrast, mice developing CTL responses against the p572 and p988 low-affinity epitopes exhibit potent antitumor immunity and no sign of autoimmune reactivity against TERT-expressing normal tissues. Our results strongly argue for new TAA epitope selection and modification strategies in antitumor immunotherapy applications in humans.
Age as a risk factor for inadequate treatment
Journal: JAMA (1988)

<h3>To the Editor.</h3> —We don't agree with Dr Wetle<sup>1</sup>that "elders tolerate [chemotherapy] as well as or better than younger patients." In contrast to Dr Wetle's interpretation, the preliminary Eastern Cooperative Oncology Group data reported in 1983 by Begg and Carbone<sup>2</sup>actually did show increased toxic reactions in elderly patients with eight different solid cancers who had received methotrexate or lomustine. In addition, as acknowledged by the authors, there had been some selection bias against elderly patients in these studies and the median age had not been reported. These results therefore cannot be considered as being representative of the total elderly population with cancer. Other studies on the treatment of elderly patients with cancer suggest that chemotherapy-related toxic reactions occur more often than in younger patients. Armitage and Potter<sup>3</sup>retrospectively evaluated the outcome of 20 patients 70 years of age or older with diffuse histiocytic lymphoma, predominantly
Psychoprosthetics
Authors: Todd Alan Kuiken
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12274: Endothelium-specific Deletion of Epsins Attenuates Atherosclerosis Through Maintaining ER Homeostasis
Authors: Yunzhou Dong, Ashiqur Rahman, Xiaolei Liu, Hao Wu, Megan Brophy, Hong Chen
Journal: Circulation (2015)

Epsins are endocytotic proteins for the internalization of plasma membrane receptors. Our previous studies have suggested that epsins play an important role in tumorigenesis and lymphatic development by modulating VEGFR2, VEGFR3 or Wnt signaling. Whether epsins affect atherosclerosis remains unknown. In an ApoE-deficient murine model, endothelial-specific double knockout mice (EC-iDKO/ApoE-/-) significantly attenuated atherosclerotic lesion and macrophage infiltration in aortic root and aortic arch compared to ApoE-/- mice fed Western diet for ten weeks. Endothelium-dependent relaxation is significantly improved in epsin-deficient mice. Mechanistically, the expression of epsins is upregulated in atheroma and mouse endothelial cells in a pro-inflammatory condition, mirrored in human atherosclerotic specimen. Proteomics study using Mass spectrometry revealed that epsins bind IP3R1 and facilitate its degradation in endothelium under inflammatory condition. Downregulation of IP3R1 by athero-prone substances augmented ER stress and NFkB signaling, reversible by ER stress inhibitor 4-PBA. In line with the findings from mouse studies, IP3R1 is dramatically downregulated in human atherosclerotic endothelium. Loss of epsins stabilized IP3R1, and attenuated ER stress-dependent NFkB activation and inflammatory signaling as evidenced by the reduced expression of P-selectin, adhesion molecules, and chemoattractant MCP-1 in primary mouse aortic endothelial cells (MAEC), and reflected by in vitro rolling analysis between isolated MAEC and macrophage from mouse. Molecular modeling and mapping analysis revealed that epsin UIM is critical to facilitate the degradation of IP3R1. In conclusion, we have identified a novel molecular mechanism regarding epsins in the regulation of atherosclerosis, and our data suggest that epsins are a potential target to treat atherosclerosis.
BMI Can Underestimate Breast Cancer Risk
Journal: Cancer Discovery (2018)

New findings suggest that postmenopausal women with high levels of body fat are at increased risk of ER-positive breast cancer, even if their body mass index is within the normal range. If confirmed, these results would put many more women at elevated risk for breast cancer than was previously thought, with implications for the way that healthy-weight women should be counseled to reduce their health risks.
The modern clinical laboratory; Justification, scope, and directions
Authors: G. D. Lundberg
Journal: JAMA (1975)

THE HUGE variety and volume of available laboratory tests confronts the physician with a major dilemma. What tests should he order on what patients? When, how, how often, at what cost, grouped or individually, and in what sequence? What is the interpretation of the results and what steps then should be taken? The frequency with which a laboratory test may be ordered varies from none to constant monitoring of all variables. What should be done? What constitutes good laboratory medicine? Should the physician order one of each available laboratory test on each patient once a lifetime, once a year, once an hour, or never? Many forces influence these decisions. Among them are availability of laboratory service, policies of technical instrument and reagent manufacturers, and economic considerations, such as cost, and who makes the profit or takes the loss, in addition to what the physician knows about the medical need for
Match March
Authors: W. E. Golden
Journal: JAMA (1980)

ON WEDNESDAY of this week, nearly 16,000 envelopes were anxiously opened; their contents spelled the future for the entire graduating class of this nation's medical education system. Celebrations and commiserations began forthwith: the 1979-1980 National Residents Matching Program (NRMP) had come to its long-awaited climax. Attaining a first-year residency position has become a lengthy project requiring planning, social ingenuity, and, frequently, a fair amount of money. With the exception of some subspecialty programs the days of individual students seeking private agreements with house staff programs ended 28 years ago with the creation of the NRMP. The selection process was computerized to avoid thousands of students trying to gain the early favors of program directors before all desirable house staff positions were filled. The expansion of medical school enrollment during the 1970s and the relative stability in the number of first-year residency positions now exert pressures on the system that make
Marriages.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Unusual Case of Mixed-Dust Exposure Involving a "Noncommercial" Asbestos
Authors: Ronald F. Dodson, Jeffrey L. Levin
Journal: Environmental Health Perspectives (2001)

Our health center evaluated an individual for suspected pneumoconiosis, which had resulted from exposures in a foundry/metal reclamation facility. Appropriate consent forms were obtained for the procedures. Historically, individuals who work in foundries have been exposed to various types of dusts. The clinical findings in this case were consistent with silicosis with a suspicion of asbestos-induced changes as well. A sample from this individual, analyzed by electron microscopy, showed both classical and atypical ferruginous bodies. The uncoated fiber burden in this individual indicated an appreciable number of anthophyllite asbestos fibers. This finding, coupled with analysis of cores from ferruginous bodies and the presence of ferruginous bodies in areas of interstitial fibrosis, pathologically supported the diagnosis of asbestos-related disease. The unique factor associated with this case is that unlike in some settings in Finland where anthophyllite was mined and used commercially, this mineral fiber is not commonly found in commercially used asbestos products in the United States. Although the actual source of the asbestos exposure in this case is still being sought, it should be recognized that anthophyllite is a contaminant of many other minerals used in workplace environments, including foundries. The fiber burden indicates a unique type of exposure, differing from that usually construed as typical in occupational settings in the United States.
Portuguese Society of Digestive Endoscopy (SPED)www.sped.pt
Journal: Endoscopy (2018)

The Portuguese Society of Digestive Endoscopy (SPED) has had a productive year filled with numerous activities aimed at its members. In previous newsletters, the initiatives promoted by the Quality Committee, the Education Committee and SPED Young have already been featured. SPED would therefore like to highlight some other projects that have made us proud in this past year.
Monitoring Occupational Exposure to Ethylene Oxide by the Determination of Hemoglobin Adducts
Authors: Nico J. van Sittert, Gerard D. J. Beulink, Erik W. N. van Vliet, Henk van der Waal
Journal: Environmental Health Perspectives (1993)

In a study on workers in a chemical plant where ethylene oxide (EtO) is manufactured and partly used for ethylene glycol production, exposure to EtO was monitored during annual periodic health assessments in January 1988, December 1988, and March 1990 by the determination of the level of 2-hydroxyethylvaline (HOEtVal) in hemoglobin. The HOEtVal levels in workers corresponded with the potential EtO exposures. The highest level was found in December 1988, in blood samples collected 1-2 months after a shut-down, maintenance, and start-up program. The range of adduct levels found in the three examinations indicated that average EtO exposures during the 4 months preceding blood sampling were below 0.5 ppm. It was demonstrated that the method allows for the accurate monitoring of low levels of EtO exposure and provides personalized time-integrated exposure data with great discriminative power. In addition, the method may serve to identify unexpected personal exposures, which may lead to targeted exposure control measures.
Pulmonary Toxicity in Hamsters of Smoke Particles from Kuwaiti Oil Fires
Authors: Joseph D. Brain, Nancy C. Long, Susan F. Wolfthal, Thomas Dumyahn, Douglas W. Dockery
Journal: Environmental Health Perspectives (1998)

The Kuwaiti oil wells set on fire by retreating Iraqi troops at the end of the Persian Gulf War released complex particles, inorganic and organic gases, and hydrocarbons into the atmosphere, damaging the environment where many people live and work. In this study, we assessed the health effects of particles from the Kuwaiti oil fires by instilling hamsters intratracheally with particles (<3.5 microM in size) collected in Ahmadi, a residential area in Kuwait located downwind of hundreds of oil fires. Twenty-four hours after instillation, we performed bronchoalveolar lavage (BAL) to assess various indicators of pulmonary inflammation, including neutrophil and macrophage numbers; albumin, an index of air-blood barrier permeability; and activities of three enzymes: lactate dehydrogenase (LDH; an indicator of cell injury), myeloperoxidase (MPO; which indicates activation of neutrophils), and ss-N-acetylglucosaminidase (GLN; which is indicative of damage to macrophages or neutrophils). We compared the response of hamsters instilled with particles from Ahmadi to animals instilled with urban particles collected in St. Louis, Missouri. We also compared the Ahmadi particles against a highly fibrogenic positive control ([alpha]-quartz) and a relatively nontoxic negative control (iron oxide). When compared to hamsters instilled with particles from St. Louis, the animals treated with the Ahmadi particles had between 1.4- and 2.2-fold more neutrophils in their BAL fluids. The Ahmadi hamsters had more macrophages and lower MPO and LDH activities, but comparable albumin levels and GLN activities. Thus, the acute toxicity of the Ahmadi particles was roughly similar to that of urban particles collected in the United States, when identical masses were compared. However, the relatively higher concentrations of particles measured in Kuwait and Saudi Arabia during the oil fires (at times more than 16 times higher than the EPA standard) is of particular concern. In addition, since the long-term effects of exposure to these particles remains unknown, further studies are needed to fully assess the health effects of the Kuwaiti oil fires.
Substance Abuse
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiologia clinica da vesicula biliar normal e pathologica pela cholecystographia.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metastatic occult follicular thyroid carcinoma
Authors: T. Boehm
Journal: JAMA (1976)

FOLLICULAR carcinoma of the thyroid with distant metastases is considered a relatively progressive tumor associated with a poor five-year survival rate<sup>1-3</sup>and is rare in the absence of any abnormality in the neck by palpation or scan.<sup>4</sup>The following case illustrates two unusual features: (1) slow growth of a solitary metastasis from follicular carcinoma (2) distant metastasis from a small focus of follicular carcinoma that could not be detected by palpation or isotopic scanning of the thyroid. <h3>Report of a Case</h3> A 28-year-old woman was initially seen in October 1974, with a one-year history of left occipital headaches, which had increased in frequency over the previous three months. A skull roentgenogram (Fig 1) showed a 16-mm diameter lytic lesion of the left occiput. In December 1972, she had been beaten during a family quarrel and was taken to a local hospital. Skull roentgenograms (Fig 1) obtained from this
Thromboembolic events in hospitalized cancer patients: Impact on stay duration and cost for four major cancer localizations.
Authors: Isabelle Borget, Nicolas Martelli, Alexandre Vainchtock, Florian Scotte
Journal: Journal of Clinical Oncology (2015)

e17784 Background: Cancer patients represent an at-risk population for Venous Thromboembolic Events (VTE). Our study aimed to evaluate the impact of VTE on the length and cost of hospital stay in French patients hospitalized for breast cancer (BC), colon cancer (CC), lung cancer (LC) or prostate cancer (PC). Methods: The French national hospital database (PMSI) and the disease-specific ICD-10 codes were used to identify BC, CC, LC or PC patients diagnosed in 2010 who were hospitalized with a VTE during the following two years. We selected stays during which a VTE occurred but was not the main reason of hospitalization (cancer was classified as primary/related diagnosis and VTE as significant associated diagnosis). Those stays were matched and compared to similar stays (same cancer and same reason for hospitalization) without VTE. Costs were calculated using the French official tariffs, from the perspective of the third-party payer. Results: We identified 214 stays for breast cancer during which a VTE occurred and was classified as significant associated diagnosis, 843 stays for colon cancer, 1,301 for lung cancer and 126 for prostate cancer. The comparison between those stays and similar stays without VTE showed a significant increase of hospital stay duration in patients experiencing VTE. Median duration raised from 4 to 7 days in BC patients, from 8 to 16 days in CC, from 2 to 9 days in LC and from 6 to 10 days in PC. Consequently, the median expenditure per stay increased by 37% in BC patients with VTE (up to € 5,518), by 61% in CC (up to € 9,878), by 202% in LC (up to € 7,308) and by 22% in PC (up to € 6,200). Conclusions: When occurring during hospitalization, VTE made cancer management heavier: patients faced prolonged hospital stays whereas healthcare system faced significant additional cost. Better prevention and follow-up measures could reduce this burden, and benefit both patients and hospitals. Median hospital stay duration and cost in cancer patients with and without VTE as SAD. Breast cancer Colon cancer Lung cancer Prostate cancer Duration (days) Cost Duration (days) Cost Duration (days) Cost Duration (days) Cost With VTE 7 € 5,518 16 €9,878 9 €7,308 10 € 6,200 Without VTE 4 € 4,018 8 €6,171 2 €2,422 6 € 5,094
Book Listings
Journal: Annals of Internal Medicine (2000)

Book Listings5 December 2000Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-11-200012050-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyCoronary Circulation and Myocardial IschemiaMR Pinsky, A Artigas, and J Dhainaut, eds. 193 pages. New York: Springer-Verlag; 2000. $109.00. ISBN 3540625844. Order phone 800-777-4643.Dates in CardiologyH Lee, ed. 129 pages. New York: Parthenon; 2000. $29.00. ISBN 1850704988. Order phone 800-735-4744.Drugs, Enzymes and Receptors of the Renin-Angiotensin System: Celebrating a Century of DiscoveryA Husain and RM Graham, eds. 399 pages. Newark, NJ: Gordon and Breach/Harwood Academic; 2000. $148.00. ISBN 9058230384. Order phone 800-545-8398.Epidemiology of HypertensionCJ Bulpitt, ed. 706 pages. New York: Elsevier Science; 2000. $275.00. ISBN 044482779X. Order phone 212-989-5800.Jesse E. Edwards' Synopsis of Congenital Heart ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 December 2000Volume 133, Issue 11Page: B1KeywordsInterleukins ePublished: 5 December 2000 Issue Published: 5 December 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...