tbuckley/cabot-search huggingface dataset:
Comparison of the 6th and 7th editions of the UICC TNM staging system for gastric cancer: Results of a Chinese single-institution study of 1,503 patients.
Authors: W. Wang
Journal: Journal of Clinical Oncology (2011)

117 Background: To evaluate the prognostic efficacy of the 7th edition TNM classification compared to the 6th edition in gastric cancer patients. Methods: A total of 1,503 gastric cancer patients undergoing surgical resection were staged using the 6th and 7th edition staging systems. Homogeneity, discriminatory ability, and monotonicity of gradients of the two systems were compared using linear trend X 2 , likelihood ratio X 2 statistics, and Akaike information criterion (AIC) calculations. Results: Significant differences in five-year survival rates were observed for the “T,” “N,” and “M” subgroups using the 7th edition system, except for stage N2 and N3 patients in the 6th edition system. There were no significant differences in survival between IB and IIA in the 7th edition system. Patients with stage IV disease due to T4/N3 in the 6th edition system who were downstaged to stage III in the 7th edition system had significantly better survival than those who remained at stage IV. The 7th edition system had higher linear trend and likelihood ratio X 2 scores, and smaller AIC values compared with those for the 6th edition, which represented the optimum prognostic stratification. Conclusions: Our study suggested that the 7th edition system performs superior to the 6th edition in several aspects. No significant financial relationships to disclose.
THE BLOOD PLATELETS AND THE SPLEEN
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1968 medical disciplinary report
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatitis A Transmission Hits Group Homes for the Disabled
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Crohn's colitis and ileorectal anastomosis.
Journal: BMJ (1976)

The marine bacterium Vibrio parahaemolyticus, a known cause of gastroenteritis from seafoods, especially abroad,1011 also occurs in British coastal waters12-though only one incident traced to home-produced crabmeat has been reported.13The vibrio is often present in imported crustacea, especially shrimps and prawns from the Far East, and these have been reponsible for some recent incidents.14Though this organism may multiply rapidly, even at low temperatures, it is fully sensitive to heat: as with most microbial pathogens control thus lies in sound hygienic practice during and after processing.The consumption of any food raw inevitably carries some risks to health, and shellfish are no exception.Adequate heat treatment would, however, overcome most of them.Perhaps further education in cooking and eating these interesting foods is needed-who's for oyster or mussel pie ?
Editorial: Progress in dissolving gallstones.
Journal: BMJ (1975)

Research interestl 2 remains high in the gallstone-dissolving agent chenodeoxycholic acid (CDC), and some progress has been made in the two years since our last leading article3 in defining its mode of action, its probable clinical role, and its possible toxicity.The key effect of CDC is probably suppression of the synthesis of cholesterol by the liver.A recent study4 of four patients given the quite small dose of 500 mg daily showed an average 40% reduction in the "input of cholesterol into the
Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. IV. A preliminary report on phenoformin results
Authors: G. L. Knatterud
Journal: JAMA (1971)

The University Group Diabetes Program (UGDP), a long-term prospective clinical trial, was designed to evaluate the effects of various hypoglycemic agents on vascular complications in patients with asymptomatic, adult-onset diabetes. This study provided no evidence that phenformin was more efficacious than diet alone or than diet and insulin in prolonging life for the patients studied. In fact, the observed mortality from all causes and from cardiovascular causes for patients in the phenformin treatment group was higher than that observed in any of the other treatment groups. In addition, there was no evidence that phenformin was more effective than any of the other treatments in preventing the occurrence of nonfatal vascular complications associated with diabetes. For these reasons, the use of phenformin has been terminated in the UGDP. Data collection in this study is continuing for all surviving patients. The additional information obtained over a longer period of follow-up on patients in the two insulin groups compared with the patients in the placebo group will provide a more adequate basis for the assessment of the long-term effects of insulin.
Announcement: 20th Anniversary of PulseNet: the National Molecular Subtyping Network for Foodborne Disease Surveillance — United States, 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

PulseNet is celebrating 20 years of public health achievements in transforming the way foodborne disease outbreaks are detected and investigated. PulseNet is a national surveillance network of federal, state, and local public health laboratories that work together to detect foodborne disease outbreaks by connecting DNA fingerprints of bacteria that cause illness (1). The network facilitates the early identification of common sources of foodborne outbreaks and helps regulatory agencies identify areas where implementation of new measures are likely to improve the safety of the food supply.
Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels
Authors: Yi-Quan Tang, Sol Ah Lee, Mizanur Rahman, Siva A. Vanapalli, Hang Lu, William R. Schafer
Journal: Neuron (2020)

(Neuron 107, 112–125.e1–e10; July 8, 2020) It was recently brought to the authors’ attention that the western blots in Figures 2E, 4D, and 4G were labeled in a potentially confusing way. Specifically, the “+” and “−” labels for the first lanes of these western blots were intended to indicate whether these lanes contain the bait (TMC-1 fragment in Figures 2E and 4G and UNC-44 in Figure 4D); the text label indicated the prey in the experiment (CALM-1 in Figures 2E and 4D and UNC-44 in Figure 4G). However, because these text labels were positioned next to the “+” and “−” labels, this might lead to the misunderstanding that there was no prey rather than no bait. In addition, in Figure 4F, the label for UNC-44-V5 in the first lane was inadvertently labeled as “−” instead of the correct “+.” All these labels have been amended, and corrected figures are shown below. While this correction does not affect the findings or the conclusions of the study, the authors would like to apologize for this error and any confusion or inconvenience that the original labeling may have caused.Figure 2ECALM-1 Is Required for TMC-1-Mediated Mechanosensation in OLQ Neurons (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 4UNC-44/Ankyrin Binds Indirectly to TMC-1 via CALM-1 (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 4UNC-44/Ankyrin Binds Indirectly to TMC-1 via CALM-1 (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Ankyrin Is An Intracellular Tether for TMC Mechanotransduction ChannelsTang et al.NeuronApril 22, 2020In BriefTMC channels are important for sensory transduction, notably as key components of the hair cell mechanotransducer. In this issue of Neuron, Tang et al. show that the mechanosensory activity of C. elegans TMCs requires the intracellular tether ankyrin, which interacts with TMC-1 through the adaptor protein CALM-1. Full-Text PDF Open Access
Allergy to radioisotopes nonexistent
Authors: A. Miale
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The free medical clinics (<b>219</b>:603, 1972) deserve more support and encouragement from the medical profession, and it would be a great loss if they would not survive. The idealism of the young physicians and students is in the best tradition of medicine and the wild talk and the political stance should not make us uptight and negative in our attitude. Stripped of some of the verbiage, these clinics are no new departure. During the war, when venereal disease was rampant, such clinics operated in many places. They were staffed by volunteer medical men and students and the team included nurses, social workers, epidemiologists, and volunteer workers. They were free clinics, no admission fees were charged during daytime and a nominal sum was charged for night clinics. The organization was rather "peer" to use the fashionable word, though the head nurse tended to boss as all do
Immunotherapy in bee-sting anaphylaxis. Use of honeybee venom
Authors: W. W. Busse
Journal: JAMA (1975)

After nine months of immunotherapy with commercially prepared wholebody bee extract, a beekeeper's wife experienced anaphylaxis after a controlled bee-sting challenge. High risk of future bee stings prompted a decision to attempt desensitization with honeybee venom. This was extracted from the bee into Coca solution and administered parenterally in increasing daily doses until an equivalent of one venom sac was given per day. This maintenance dosage was continued for a month. Anaphylaxis did not occur after another bee-sting challenge. Therapy has been maintained with venom. With this treatment, there has been an increase in the level of IgG-blocking antibody and a fall in IgE titer to bee venom (radioallergosorbent test [RAST]). (<i>JAMA</i>231:1154-1156, 1975)
Ciprofloxacin and long-term prevention of spontaneous bacterial peritonitis: Results of a prospective controlled trial
Authors: Alain Rolachon, Laurent Cordier, Yannick Bacq, Jean-Baptiste Nousbaum, Anne Franza, Jean-Claude Paris, Serge Fratte, Benoit Bohn, Pascal Kitmacher, Jean-Paul Stahl, Jean-Pierre Zarski
Journal: Hepatology (1995)

The aim of this prospective double-blind study was to evaluate the value of long-term antibiotic prophylaxis using ciprofloxacin for the prevention of spontaneous bacterial peritonitis (SBP) in 60 cirrhotic patients with low ascitic fluid protein levels (&lt;15 g/L). The patients were assigned to two groups: group I (n = 28) ciprofloxacin 750 mg per os once a week for 6 months, group II (n = 32) placebo. The two groups were similar for clinical and laboratory characteristics. Twelve patients developed an intercurrent disorder, and 10 patients died during the trial. There were no adverse effects in the treated group. There was a significant decrease in the incidence of SBP (3.6 vs. 22%) ( P &lt; .05) and duration of hospitalization (9.3 ± 4.5 vs. 17.6 ± 6.2 days) ( P &lt; .05) in the treated group as compared with the placebo group. The bacteriological study showed no acquired resistance to ciprofloxacin after 6 months’ treatment. These results suggest that long-term preventive antibiotic prophylaxis based on the weekly administration of 750 mg of ciprofloxacin is effective in the prevention of SBP in cirrhotic patients. (Hepatology 1995; 22:1171-1174.).
Emotional intelligence and patient-centred care
Authors: Yvonne F Birks, Ian S Watt
Journal: Journal of the Royal Society of Medicine (2007)

The principles of patient-centred care are increasingly stressed as part of health care policy and practice. Explanations for why some practitioners seem more successful in achieving patient-centred care vary, but a possible role for individual differences in personality has been postulated. One of these, emotional intelligence (EI), is increasingly referred to in health care literature. This paper reviews the literature on EI in health care and poses a series of questions about the links between EI and patient-centred outcomes. Papers concerning empirical examinations of EI in a variety of settings were identified to determine the evidence base for its increasing popularity. The review suggests that a substantial amount of further research is required before the value of EI as a useful concept can be substantiated.
Nosocomial transmission of tuberculosis in a hospital unit for HIV-infected patients
Authors: S. W. Dooley
Journal: JAMA (1992)

<h3>Objective.</h3> —To assess nosocomial transmission of tuberculosis (TB). Design.—A historical cohort study of hospitalized patients with the human immunodeficiency virus (HIV) and a purified protein derivative (PPD) tuberculin skin test survey of health care workers (HCWs). <h3>Setting.</h3> —A large public teaching hospital in San Juan, Puerto Rico. <h3>Patients.</h3> —For the cohort study, a case patient was defined as any patient in the HIV unit at the hospital who developed culture-positive TB from 31 days or more after admission through December 31, 1989. For the PPD survey, of 1420 HCWs from the hospital, 908 agreed to participate and had sufficient data for analysis. <h3>Main Outcome Measures.</h3> —For the cohort study, to compare the risk of developing active TB among patients who were exposed to hospital roommates with infectious TB and the risk among nonexposed patients. For the HCW PPD survey, to determine the prevalence of and risk factors for tuberculous infection. <h3>Results.</h3> —Eight of 48 (9.7/10000 person-days) exposed case patients vs four of 192 (0.8/10000 person-days) nonexposed case patients developed active TB (relative risk [RR]=11; 95% confidence interval [CI], 2.3, 50.3). Positive PPDs (≥10 mm of induration) in HCWs were associated with older age (<i>P</i>=.0001) and with history of community TB exposure (<i>P</i>=.0002). In a multivariable logistic model that adjusted for these variables, HIV unit nurses (nine of 19) and nurses in the internal medicine ward (45 of 90) had a higher proportion of positive PPDs than the reference group (clerical personnel on other floors: 35 of 188,<i>P</i>=.0005). <h3>Conclusions.</h3> —These data suggest that patient-to-patient transmission of TB in HIV units can occur and that HCWs are at risk of acquiring TB infection. (<i>JAMA</i>. 1992;267:2632-2635)
Scientific Exhibits and Posters
Authors: Mccormick Place, West-R Donnelley Hall, Robert Reinecke, Frank Holly, David Lamberts, James Price, Carl Kupfer, Wayne Fung, San Francisco, Mark Abelson, Gilbert Yamamoto, Ira Udell, Mathea Allansmith, S Boyce, Kenneth Hoffer, Santa Monica, Jerry Shields, James Augsburger, Jay Federman, Jeffrey Shakin, Gary Brown, Norman Felberg, Terrance Tomer, Eugene Helveston, Forrest Ellis, Edward O'malley, Kenneth Julian, Peter Evans, Thomas Kirby, Robert Monahan, Richard Augustine, Alice Liska, Jeanne Kapeller, William Ludwick, Los Angeles, Ogden Frazier, Ron Zielinski, Barrett Walker, Csaba Martonyi, E Carroll, David Newsome, Eye Care, Douglas Steel, Richard Villasenor, James Salz, Ezra Maguen, Anthony Nesburn, Ronald Smith, William Milam
Journal: Ophthalmology (1980)
A New Method of Direct Electrization of the Stomach.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Settling the UGDP controversy
Authors: T. C. Chalmers
Journal: JAMA (1975)

A long-awaited assessment of the validity of the indictment of oral hypoglycemic agents by the University Group Diabetes Program (UGDP)<sup>1</sup>is appearing in this issue. Because the controversy stirred up by the report centered around the biostatistical aspects of this and other long-term trials of the oral agents, the Director of the National Institutes of Health (NIH) contracted with the prestigious Biometric Society to appoint a committee of distinguished biostatisticians to review the pertinent studies in detail. This has now been accomplished in a most thorough manner. The overall judgment of the experts is that the shortcomings of the UGDP study are not sufficient to invalidate the results, and these are not contradicted by the other studies. The probability that oral hypoglycemic agents cause premature deaths from cardiovascular disease remains valid. Statistically valid studies do not prove anything. They merely give the practitioner a probability estimate on which to
Randomized trial of postoperative adjuvant therapy in stage II and III rectal cancer to define the optimal sequence of chemotherapy and radiotherapy: A final report
Authors: T. Kim, J. Lee, J. Lee, K. Lee, Y. Kang, C. Yu, J. Kim, S. Ahn, J. Kim, J. Lee
Journal: Journal of Clinical Oncology (2007)

4050 Background: We conducted a prospective randomized trial to define the optimal sequence of chemotherapy and radiotherapy of postoperative adjuvant treatment in stage II and III rectal cancer. Methods: Three hundred eight patients were enrolled onto the study. We randomly assigned 155 to arm I (early radiotherapy group) and 153 to arm II (late radiotherapy group). Treatment included eight cycles of chemotherapy at 4-week intervals and pelvic radiotherapy of 45 Gy in 25 fractions. Radiotherapy started on day 1 of the first chemotherapy cycle in arm I and on day 1 of the third chemotherapy cycle in arm II. The chemotherapy regimen consisted of fluorouracil 375 mg/m 2 /d and leucovorin 20 mg/m 2 /d. Chemotherapy was administered for 3 days per cycle in two cycles during the period of radiotherapy and for 5 days per cycle in the remaining six cycles. (J Clin Oncol 2002 20:1751- 8) Results: Twenty patients in arm I and 14 in arm II were not eligible. We included 274 patients in the analysis. With a median follow-up of 94 months for surviving patients, there was a trend for improved disease-free survival(DFS) in arm I compared with arm II, although it was not reached statistical significance (72% v. 63% at 7 years; P =.157). Especially, in patients who received abdominoperineal resection (APR), DFS was prolonged in arm I compared with arm II (66% v. 41% at 7 years; P=.033) Thirty six recurrences (26.7%) occurred in arm I and 49 (35.3%) in arm II (P =.151). Overall survival was not significantly different between arms I and II (71% v. 68% at 7 years; P =.855). Conclusions: With a long-term follow-up, this study failed to show a significant survival advantage for early radiotherapy with concurrent chemotherapy after resection of stage II and III rectal cancer. In patients with APR, significant improvement in DFS for arm I was observed. No significant financial relationships to disclose.
TRANSIENT HEART MURMURS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal