tbuckley/cabot-search huggingface dataset:
Syndromes and Themes of Psychotic Depression
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maternal Deaths from Aspiration Asphyxia
Authors: A. H. Morley
Journal: BMJ (1963)

BICaNAL 25 yards, better visual acuity is needed to see them.This small change may make little difference to the majority of drivers but could be of great significance to the border-line cases, in particular the elderly who live in isolated country areas.It would be interesting to know whether the new or the old size of letter- ing should now be used when examining would-be drivers, and whether there are to be any more insidious alterations in the visual requirements which are of a statutory character.-Iam, etc.,
Melanoma Clinical Practice Guidelines in Oncology
Journal: Journal of the National Comprehensive Cancer Network (2004)

It should be emphasized that these treatment practice guidelines are guidelines, not absolute recommendations for treatment. They represent an effort to distill and simplify an enormous body of knowledge and experience into fairly simple management algorithms. In general, treatment recommendations for primary tumors are based on better data than the recommendations for treating recurrent disease. Few, if any, firm recommendations can be made about more controversial issues such as the extent of work-up or intensity of follow-up of the melanoma patient. These guidelines are intended as a point of departure, recognizing all clinical decisions about individual patient management must be tempered by the clinician's judgment, and factors such as local resources and expertise and the individual patient's needs, wishes, and expectations. Furthermore, these guidelines are undergoing continual revision and upgrading as new data become available.
Abstract 13435: Deranged Intra-Cardiac Blood Flow Components and Kinetic Energy in Dilated Cardiomyopathy Are an Additional Marker of Disease Severity and Correlate With Established Markers of Prognosis
Authors: Victoria Stoll, Aaron Hess, Eylem Levelt, Jonatan Eriksson, Petter Dyverfeldt, Tino Ebbers, Saul Myerson, Carl-Johan Carlhäll, Stefan Neubauer
Journal: Circulation (2015)

Introduction: Heart failure (HF) due to dilated cardiomyopathy (DCM) is a complex syndrome in which numerous cellular, mechanical and flow processes/interactions become deranged. Insights into derangement of left ventricular intra-cardiac flow patterns and kinetic energy (KE) are now afforded by the use of 4D flow CMR. Previous studies have found derangements of intra-ventricular flow components and KE within DCM patients compared to healthy volunteers. Hypothesis: We hypothesised that increasing derangement in 4D flow measures would relate to: 1) decreased mechanical cardiac function, as assessed by myocardial strain, 2) increased levels of biochemical remodelling markers and 3) worsening patient symptoms and functional capacity. Methods: 26 idiopathic DCM patients (69% male, mean age 55±2 yr, LVEF 35±2%) and 10 controls (70% male, mean age 57±4yr, LVEF 68±1.2%) were assessed with 3T CMR. Results: The LV volume was divided into 4 functional components; direct flow (DF), delayed ejection flow (DEF), retained inflow (RI) and residual volume (RV). Compared to controls DCM’s had significantly decreased DF (11±1% vs 38±2%) and increased RV (51±2% vs 31±1%) (fig a). The KE at end diastole differed significantly for all flow components between groups (fig b). Circumferential strain was significantly impaired in DCM’s vs controls (-9.9±0.8% vs -19.7±0.5%, p&lt;0.0001). DF KE correlated positively to the 6 minute walk test (6MWT) and strain, and negatively to the Minnesota HF questionnaire and BNP (fig c). Conclusions: DCM patients demonstrated less efficient blood flow patterns and deranged KE profiles. The greater the derangement of flow parameters from normal, the worse the myocardial strain, BNP, 6MWT and patient symptoms. This study suggests that flow parameter derangements are novel biomarkers of disease severity in DCM, correlating with established markers of prognosis such as BNP and 6MWT and may become useful in monitoring novel therapies and predicting prognosis.
HIV Instruction and Selected HIV-Risk Behaviors Among High School Students—United States
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: “Projecting Age-Stratified Risk of Exposure to Inland Flooding and Wildfire Smoke in the United States under Two Climate Scenarios”
Authors: David Mills, Russell Jones, Cameron Wobus, Julia Ekstrom, Lesley Jantarasami, Alexis St. Juliana, Allison Crimmins
Journal: Environmental Health Perspectives (2018)

[This corrects the article DOI: https://doi.org/10.1289/EHP2594.].
Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue
Authors: Susana Ortiz-Urda, Qun Lin, Cheryl L. Green, Douglas R. Keene, M. Peter Marinkovich, Paul A. Khavari
Journal: Journal of Clinical Investigation (2003)

Current therapeutic strategies for genetic skin disorders rely on the complex process of grafting genetically engineered tissue to recipient wound beds. Because fibroblasts synthesize and secrete extracellular matrix, we explored their utility in recessive dystrophic epidermolysis bullosa (RDEB), a blistering disease due to defective extracellular type VII collagen. Intradermal injection of RDEB fibroblasts overexpressing type VII collagen into intact RDEB skin stably restored correctly localized type VII collagen expression in vivo and normalized hallmark RDEB disease features, including subepidermal blistering and anchoring fibril defects.
Small extracellular vesicles from mesenchymal stem cells pre-conditioned with interferon-? can improve liver fibrosis by inducing anti-inflammatory macrophages with high migratory and phagocytotic abilities
Authors: Suguru Takauchi, Atsunori Tsuchiya, Masaru Kumagai, Takeki Sato, Satoko Motegi, Takahiro Iwasawa, Shunsuke Nojiri, Masahiro Ogawa, Masaaki Takamura, Shuji Terai
Journal: Journal of Hepatology (2020)
appendix 6: Chronic lymphocytic leukaemia: eUpdate published online September 2016 (http://www.esmo.org/Guidelines/Haematological-Malignancies)
Authors: B. Eichhorst, T. Robak, E. Montserrat, P. Ghia, P. Hillmen, M. Hallek, C. Buske
Journal: Annals of Oncology (2016)
Highlights
Journal: JAMA (2014)

PET-CT Before Resection of Liver Metastases 1863To determine the effect of preoperative positron emission tomography combined with computed tomography (PET-CT) on the surgical management of potentially resectable liver metastases in patients with colorectal cancer, Moulton and colleagues randomly assigned 263 patients to undergo PET-CT or to a control condition that included baseline (prerandomization) CT of the abdomen-pelvis area but no PET-CT.The authors found that compared with CT alone, use of PET-CT rarely resulted in a change in surgical management-defined as canceled hepatic surgery, more extensive hepatic surgery, or additional organ surgery.Effect on LDL-C Levels of Evolocumab Added to Statin Therapy 1870
ERRATUM
Authors: Stephen Spiro, Lindsay James, Robin Rudd, Colin Trask, Jeffrey Tobias, Michael Snee, David Gilligan, Philip Murray, Mary Carmen Ruiz De Elvira, Andrea Bezjak, Dongsheng Tu, Lesley Seymour, Gary Clark, Aleksandra Trajkovic, Mauro Zukin, Joseph Ayoub, Sergio Lago, Ronaldo De, Albuquerque Ribeiro, Alexandra Gerogianni, Arnold Cyjon, Jonathan Noble, Francis Laberge, Tsz-Tong Chan, David Fenton, Daniel Haller, Torunn Yock, Mark Krailo, Christopher Fryer, Sarah Donaldson, James Miser, Zhengjia Chen, Jan Buckner, Karla Ballman, John Michalak, Gary Burton, Terrence Cascino, Paula Schomberg, Sandra Strauss, Frank Morschhauser, Juergen Rech, Roland Repp
Journal: Journal of Clinical Oncology (2006)

contained errors.In Figure 2, inaccurate data were reported.The corrected figure is reprinted below in its entirety.In Figure 3, the legend should have read: "Pharmacokinetics of ADI-SS PEG 20,000 mw in (A) and (C) US patients and (B) and (D) Italian patients with melanoma.The amount of arginine deiminase (ADI) enzyme activity in plasma (A) and (B) and the amount of ADI protein present (C) and (D) were determined.The data shown represent the means Ϯ SE of each of the cohorts."The online version has been corrected in departure from the print.
The hepatic apelin system: A new therapeutic target for liver disease
Authors: Teoman Dogru, Cemal Nuri Ercin, Gokhan Erdem, Guldem Kilciler, Serkan Tapan
Journal: Hepatology (2008)

Apelin is a new member of adipose tissue–derived peptides which is also produced in the endothelial cells in various parts of the body.1 It is synthesized as a prepropeptide, and smaller peptides having higher potency are subsequently produced by posttranslational modification. It works through a cell surface G protein–coupled receptor called APJ, which has structural similarity with angiotensin type I receptor.2 In a recent issue of HEPATOLOGY, we read with great interest the article by Principe et al. investigating the apelin system in advanced liver disease.3 In conclusion, the authors pointed out the selective hepatic activation of the apelin system, together with the drop in fibrosis and neoangiogenesis and the improvement in cardiovascular and excretory function resulting from apelin receptor blockade. This work is important because it provides scientific information on this relevant issue. However, we have two major comments on this article. First, there is no data about the body mass index, blood pressure, insulin sensitivity, blood glucose, and lipid profiles of the subjects with cirrhosis. It is well known that plasma insulin and adipokine levels differ according to the degree of glucose dysregulation.4, 5 This point is also true for hypertension or elevated blood pressure.6 Plasma apelin levels were reported to increase in obesity in association with hyperinsulinemia.7 In addition, we recently showed decreased circulating apelin levels in subjects with dyslipidemia and also type 2 diabetes mellitus.8, 9 Secondly, no information about the drug use of the subjects could be seen in the text. We know that circulating adipokines and measures of insulin sensitivity are easily affected from the medications started for the metabolic problems mentioned above. Moreover, we just reported the changes of blood apelin concentrations after the statin treatment.10 We think all these points make the resultant comparisons and correlations questionable. Therefore, we would like to ask the authors whether they can present some new results by categorizing the patients according to metabolic confounders such as diabetes mellitus, hypertension, and dyslipidemia. This may provide the readers clearer information about the role of the apelin system in advanced liver diseases. Teoman Dogru*, Cemal Nuri Ercin*, Gokhan Erdem , Guldem Kilciler*, Serkan Tapan , * Department of Gastroenterology, Gulhane Medical School, Ankara, Turkey, Department of Internal Medicine, Gulhane Medical School, Ankara, Turkey, Department of Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
Medizinische Welt, Stuttgart
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Patient Page
Authors: Richard Smith, M Chb, Tara Mccready, Salim Yusuf
Journal: JAMA (2013)

diovascular disease.Legislative measures take several decades to enact and implement; the World Health Organization's Framework on Tobacco Control took a decade to develop and ultimately was adopted many decades after the evidence of the harms of smoking were well established.Other legislative efforts have unclear benefits, such as the effect of salt reduction strategies on health.Should we ignore what can be done now and accept millions of premature deaths every year while waiting for society to change?It makes good clinical and public health sense to use appropriate and low-cost drugs (eg, the polypill) in conjunction with behavioral modification and legislative approaches (when the evidence is clear).Such a multifaceted approach has the potential to benefit society rapidly and to the greatest extent feasible.
Increased Brain Activation During Working Memory in Cognitively Intact Adults With the APOE ε4 Allele
Authors: Heather Wishart
Journal: American Journal of Psychiatry (2006)

Objective: Altered patterns of brain activity during cognitive tasks have been demonstrated using functional magnetic resonance imaging (fMRI) in mild cognitive impairment and Alzheimer’s disease. However, there have been few studies of adults at genetic risk for Alzheimer’s disease prior to the onset of symptoms. The purpose of this study was to determine whether brain activation patterns associated with working memory differ as a function of apolipoprotein E (APOE) genotype in cognitively intact adults. Method: Participants were cognitively intact, healthy adults who completed genotyping, comprehensive neuropsychological testing, and structural and functional neuroimaging. Twenty-two participants had the APOE ε3/ε3 genotype, and 13 participants had the APOE ε3/ε4 genotype. The study employed an auditory verbal N-back task to probe working memory-related brain activity. Results: The ε3/ε3 and ε3/ε4 groups did not differ in demographic characteristics, cognitive ability, mood, or in-scanner task performance. The ε3/ε4 group showed greater activity during working memory in the medial frontal and parietal regions bilaterally and in the right dorsolateral prefrontal cortex. There were no regions in which the ε3/ε3 group showed greater activation than the ε3/ε4 group. Conclusions: These results indicate that differences in brain activity are evident in cognitively intact individuals who are at risk for late-onset Alzheimer’s disease by virtue of their APOE allele status. As neuroprotective interventions become available, early detection will increase in importance. The combination of genetic and functional neuroimaging strategies may prove useful for monitoring individuals at risk for Alzheimer’s disease before the onset of cognitive symptoms.
OPTIONAL OR COMPULSORY GREEK AT OXFORD
Authors: A. Thomson, A. P. Dodds-Parker, S. E. Whitnall, C. S. Sherrington, H. C. Bazett, G. Dreyer, E. W. A. Walker, A. G. Gibson, A. D. Gardner, J. A. Gunn, S. H. Vines, G. C. Bourne, W. H. Perkin, D. H. Nagel, W. Collier, W. T. Brooks, R. H. A. Whitelocke, C. G. Douglas, A. L. Ormerod, E. Mallam, C. Singer, G. B. Cronshaw, H. M. Vernon
Journal: BMJ (1919)
Effect of donor age and sex on the outcome of liver transplantation
Authors: Ignazio Roberto Marino, Howard R. Doyle, Luca Aldrighetti, Cataldo Doria, John McMichael, Timothy Gayowski, John J. Fung, Andreas G. Tzakis, Thomas E. Starzl
Journal: Hepatology (1995)

We correlated donor and recipient factors with graft outcome in 436 adult patients who underwent 462 liver transplants. Donor variables analyzed were age, gender, ABO blood group, cause of death, length of stay in the intensive care unit, use of pressors or pitressin, need for cardiopulmonary resuscitation, terminal serum transaminases, and ischemia time. Recipient variables analyzed were age, gender, primary diagnosis, history of previous liver transplant, ABO blood group, cytotoxic antibody crossmatch, United Network for Organ Sharing (UNOS) status, and waiting time (except for the cross-match results, they were all known at the time of the operation). The endpoint of the analysis was graft failure, defined as patient death or retransplantation. Using multivariate analysis, graft failure was significantly associated with donor age, donor gender, previous liver transplantation, and UNOS 4 status of the recipient. The effect of donor age became evident only when they were older than 45 years. Livers from female donors yielded significantly poorer results, with 2-year graft survival of female to male 55% (95% CI, 45% to 67%); female to female, 64% (95% CI, 54% to 77%); male to male, 72% (95% CI, 66% to 78%); and male to female, 78% (95% CI, 70% to 88%). The only donors identified as questionable for liver procurement were old (±60 years) women in whom the adverse age and gender factors were at least additive. However, rather than discard even these livers, in the face of an organ shortage crisis, their individualized use is suggested with case reporting in a special category. (Hepatology 1995; 22:1754-1762).
Face Coverings in a Pandemic
Authors: Matthew D. McGraw, Satya Achanta, Jessica Castner, Diane R. Gold, Stella E. Hines, Carrie A. Redlich, Marianna M. Sockrider
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

"Face Coverings in a Pandemic." American Journal of Respiratory and Critical Care Medicine, 202(5), pp. P17–P18
Editorial Board
Authors: Zuhair Ballas, Iowa City, Iowa Deputy, David Huston, Rachel Miller, New York, N Associate, Andrea Apter, Leonard Philadelphia, St Bacharier, Claus Louis, Joshua Bachert, Boston Boyce, Robert Bush, Javier Chinen, Raif Geha, Kyoto Japan, Carole Ober, David Peden, Chapel Hill, Harald Renz, Marburg Germany, Marc Rothenberg, Cincinnati Ohio, Hirohisa Saito, Tokyo Japan, Stephan Weidinger, Robert Wood, Paul Bryce, Mariana Castells, Mitchell Grayson, Columbus Ohio, Bruce Mazer, Ariel Munitz, Kari Nadeau, Bruce Bender, Pascal Chanez, Morton Cowan, San Francisco, Elizabeth Matsui, Katrina Allen, Peter Arkwright, Arthur Gelb, Los Angeles
Journal: Journal of Allergy and Clinical Immunology (2018)
Analysis of L-Tryptophan for the Etiology of Eosinophilia-Myalgia Syndrome
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anterior communicating aneurysms. A rebuttal
Authors: J. L. Pool
Journal: JAMA (1966)

Arecent communication<sup>1</sup>unfortunately leaves the impression that the surgical treatment of ruptured anterior communicating aneurysms might just as well be abandoned because—according to statistics in that report—"No difference between the results of surgical and conservative treatment was detected, and the death-rate remained approximately the same irrespective of surgical procedure." This statement is based on a masterful five-year survey of 300 patients who had recovered, after rupture of an anterior-communicating-artery aneurysm, and were in good or reasonably good condition at the time treatment was begun. They were classified as group B, or favorable-risk patients, in contrast to the poor-risk or comatose patients of group A. On the basis of randomized selection, approximately one half of the 300 were treated by surgery and the remainder by conservative therapy. Conservative therapy, which consisted of bed rest for six weeks with or without hypotensive therapy, led to a mortality within six months of