tbuckley/cabot-search huggingface dataset:
Pathologic response to neoadjuvant therapy with nabpaclitaxel plus carboplatin followed by anthracycline regimen in triple-negative breast cancer.
Authors: Juan David Cardenas, Carmen Esteban, Iciar Garcia Carbonero, Adriana Rosero, Katherin Martinez Barroso, Miguel Borregon Rivilla, Ana Rosa Rubio Salvador, Paul Martin Aguilar Angulo, Maria Garcia Avila, Jose Ignacio Chacon, Juan Ruiz Martin
Journal: Journal of Clinical Oncology (2019)

e12117 Background: Triple-negative breast cancer (TNBC) remains a poor prognosis subtype of breast cancer (BC). We are lacking of definitive effective combinations in this tumor. So, it is warranted to explore new combinations. Neo-adjuvant setting is one of the most effective scenarios to explore a treatment efficacy. We aimed to evaluate efficacy of Nab-paclitaxel plus Carboplatin followed byanthracycline regimen by pathologic complete response (pCR: no disease in breast and axilla) in women with TNBC. Secondary endpoints were toxicity profile and breast conserving surgery. Methods: Women with stage II or III disease were included. Hormone receptors and HER2 negativity was confirmed by immunohistochemistry and/or FISH. Patients received Nab-paclitaxel 125 mg/m2 plus Carboplatin AUC 2 intravenously on days 1, 8 every 21 for four cycles followed by Epirubicin 90 mg/m2 and Cyclophosphamide 600 mg/m2 intravenously every 2 weeks for 4 cycles and subsequent surgery. Breast Magnetic Resonance was done in all cases at diagnosis and before surgery. We obtained informed consent from all patients. Results: Thirty-two patients with confirmed clinical stage II (56.3%) or III (43.7%) TNBC were treatedbetween January 2015 and February 2019. The median age of the patients was 53.1 years (30.3-77.6 years). The average of received chemotherapy was 12 doses (7-14). The mean dose of nab-paclitaxel plus carboplatin was 8 doses. All patients received surgery with or without radiotherapy. There was only one case (3.1%) of progression during neoadjuvant treatment. The rate of pCR was 50% (16) in breast and axilla, partial response 43.8% (14) and stable disease 3.1% (1). Conservative surgery was performed in 50% of patients (16). The 3/4 grade toxicities were asthenia 3.1% (1), nausea/vomiting 6.3% (2), thrombocytopenia 6.3% (2), leukopenia 6.3% (2), neutropenia 40.6% (13), febrile neutropenia 6.3% (2), diarrhea 3.1% (1), allergy 3.1% (1), peripheral neurotoxicity 3.1% (1). After a median follow-up of 18.3 months (5.0–41.9) 93.8% (30) of patients are alive. Two patients (6.3%) had early local relapse and distant relapse, respectively, and are deceased due to progression disease. Conclusions: Nab-paclitaxel plus carboplatin followed by anthracycline regimencombination as neoadjuvant treatment in TNBC achieved an encouraging rate of pCR, allowing conservative surgery in half of our patients. Toxicities were not severe in most patients and hematologic toxicity was manageable with G-CSF.
Histidinemia in mice: A metabolic defect treated using a novel approach to hepatocellular transplantation*1
Authors: C SELDEN
Journal: Hepatology (1995)

Histidinemia in mice and in humans is an autosomal recessive disorder of histidine metabolism that leads to high-histidine levels in both plasma and urine and is caused by a lack of hepatic histidine-α-deaminase (histidase). We have used a novel approach to hepatocellular transplantation to effect a complete phenotypic cure of histidinemia in a mouse model. Mice lacking histidase were treated with isolated liver cells (approximately 18 × 106 hepatocytes and 9 x 106 nonparenchymal cells) from histidase-competent donors transplanted into the peritoneum (active transplant group). Recipient mice showed a dramatic decrease, by more than 75%, in urinary histidine levels from day one throughout the course of the experiment, resulting in levels within the normal range for wild-type mice. In comparison, there was no change in urinary histidine levels in the control group of histidase-deficient mice treated with isolated liver cells from mice lacking histidase (statistical comparison between the two groups, P < .003, two-way ANOVA). Histologically, ectopic liver tissue was seen in the peritoneum in association with abdominal wall, pancreas, and peritoneal connective tissue; immunohistochemical evidence showed expression of histidase in the ectopic liver tissue in the active transplant group. This report is the first to show complete correction of a defective biochemical phenotype achieved by hepatocellular transplantation.
Endoscopic Retrograde Cholangiopancreatography
Authors: E. François, J. Devière
Journal: Endoscopy (2002)

A large international multicenter randomized trial was conducted to compare standard polyethylene biliary stents with side holes with new double-layer stents [1]. The theoretical advantages of the new stent design are the absence of side holes (suspected to facilitate bile deposition and thus obstruction) and an inner layer specifically designed to reduce clogging. The outer layer integrates generous flaps, useful for preventing stent migration, and not formed by creating a hole in the inner layer. A total of 110 patients with jaundice due to a malignant stricture of the middle or distal third of the common bile duct were randomly assigned to receive one or other stent type. The stents were 10 Fr in diameter and 5 - 7 cm in length. Twenty of 55 double-layer stents vs. 35 of 55 standard stents became clogged after a mean delay of 144 days (range 48 - 235 days) vs. 97 days (range 13 - 238 days; not statistically significant). A statistically (and clinically) significant difference was observed in stent obstruction at 3 months: 4 % for the double-layer stent vs. 20 % for the standard one. One can speculate that the greater cost of the new stents may, in the future, be shown to be offset by the reduced need for repeat procedures. The hypothesis that side holes are responsible for increased obstruction is not confirmed by a study comparing plastic stents with and without side holes. The results suggest that the presence of side holes increases patency and reduces premature clogging of biliary stents. Limitations in this study include the fact that it was not randomized and that only 90 stents were studied over a 10-year period [2].
ELECTRONIC DATA PROCESSING APPARATUS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuro-ophthalmology
Authors: J. T. W. Van Dalen
Journal: JAMA (1978)

This, the best small textbook on clinical neuro-ophthalmology available today, has been reprinted (with some revision) from volume 2 of Thomas Duane's<i>Clinical Ophthalmology</i>(Harper &amp; Row, 1977). The text is thoroughly practical, readable, and relevant for readers with widely varying experience in diagnosis of visual and oculomotor systems disorders. Its illustrations are abundant and uniformly excellent in quality, particularly the pictures of the fundus oculi. The ample literature citations are current up to 1975. The brevity of the text, 345 pages, has been achieved without loss of emphasis of diagnostically important points or omission of the interesting details. The purchase price is reasonable. There are, however, some drawbacks. Easy reading halts at the oculomotor chapters, where Dell'Osso and Daroff, by invitation, have some well-organized and modern discussions of supranuclear eye movement disorders, but obfuscate the subject with pseudomedical jargon of the bioengineer, black box servocontrol diagrams, and the unnecessary
Apple Lounge
Authors: Harriet S. Meyer
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Address.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blastomycosis—Wisconsin, 1986-1995
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OS02.4 Long-term Outcome of Infants and Young Children with Newly Diagnosed Nodular Desmoplastic Medulloblastoma Treated on “Head Start” III Protocol
Authors: G. Dhall, L. Ji, K. Haley, F. Gilles, S. Gardner, R. Sposto, J. L. Finlay
Journal: Neuro-Oncology (2017)

Background: High-dose chemotherapy with autologous hematopoietic cell rescue (AuHCR) is a potentially curative approach used in the management young children with medulloblastoma), with the additional benefit of avoiding the late-effects of craniospinal irradiation (CSI). Nodular desmoplastic medulloblastoma (NDMB) patients have been shown to have a favorable outcome in most contemporary infant clinical trials. We report the outcome of young children with NDMB treated on “Head Start” III, a ­prospective, multi-national clinical trial. Methods: Between April 2003 and December 2009, 92 children with newly-diagnosed medulloblastoma were enrolled amongst 29 participating institutions, of whom 27 patients had NDMB. All children were to receive 5 induction cycles (vincristine, cisplatin, cyclophosphamide, etoposide, high dose methotrexate - cycles 1, 3, 5), and vincristine, cyclophosphamide, oral VP-16 and temozolomide (cycles 2, 4), followed by 1 consolidation cycle of myeloablative chemotherapy (thiotepa, carboplatin, etoposide) and AuHCR. Only children between 6 -10 years old or with residual tumor pre-consolidation, were to receive irradiation after consolidation. Results: The 2-year event-free (EFS) and overall survival (OS) rates (+/- SE) for patients with ND medulloblastoma enrolled on HS III (primary objective of the study) were 89 ± 6% and 93 ± 5%, respectively. The 5-year EFS and OS rates were 89 ± 6% and 89 ± 6%, respectively. For 15 patients with localized NDMB (M0), the 5-year EFS and OS rates were 93 ± 6% and 93 ± 6%, respectively. Only one patient died, from CNS hemorrhage related to an accidental fall while undergoing induction. The remaining 14 patients are surviving without having received any irradiation. For 11 patients with disseminated NDMB (M+), the 5-year EFS and OS rates were 82 ± 12% and 81 ± 12%, respectively. One patient died from progressive disease post-transplant and one patient died of toxicity (6 months of age at diagnosis) from veno-occlussive disease and multi-organ failure post-transplant. Only 3 of remaining 9 surviving patients with M+ disease received CSI (2340cGy, 2160cGy, and 2700cGy, respectively, along with posterior fossa boost to a total dose of 5400cGy) according to protocol guidelines. One patient did not have staging work-up performed. Multi-variate Cox regression analyses of the entire cohort revealed ND medulloblastoma histology to be the only significant independent predictor of EFS after adjusting for metastatic status, initial extent of resection of the primary tumor, regimen, age and sex (p<0.001). The 5-year irradiation-free EFS rate for Desmoplastic patients was 88+/-6%. Conclusion: These are among the best survival data published so far on young children with ND medulloblastoma, while avoiding CSI in most patients, including 6 of 9 patients with disseminated disease.
Massachusetts Medical Society
Authors: Robert W. Buck
Journal: New England Journal of Medicine (1954)

Dr. Chandler of New Orleans, has been arrested for killing a gentleman from Boston.Boston M. & S. J., August 16, 1854 VERBUM SAT SAPIENTI The Proceedings of the annual meeting of the Council (May 17, 1954) were so ponderous that they were unmailable as third-class matter at 5 cents each until they were trimmed a quarter of an inch top and bottom. If unmutilated it would have been necessary to deliver them to the members of the Society at the parcel post rate of 23 cents each. This would have cost the Society $1,000 more than the expense . . .
Quantitative assessment of myocardial perfusion by myocardial contrast echocardiography with harmonic power doppler imaging Kazuaki Tanabe, Tomoko Tani, Minako Katayama, Toshikazu Yagi, Koichi Tamita, Kenji Yamabe, Atsushi Yamamuro, Tsutomu Takagi, Junichi Nagai, Shigefumi Morioka. Kobe General Hospital, Kobe, Japan
Journal: Journal of the American College of Cardiology (2001)
THE SUPERVISION OF HOSPITALS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Soy protein diet
Authors: M. L. Johnston
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In the report by Check entitled "Switch to Soy Protein for Boring but Healthful Diet" (1982; 247:3045) in the MEDICAL NEWS section, I would like to point out that a soy diet does not have to be boring. As the nutritionist for the metabolic study described, I developed four different menus for each of the three diets tested. The soy diet incorporated various soy products, including textured vegetable protein, tofu, soy flours, nuts and granules, and soybeans. Two sample soy menus are given in the Table. Menus were planned to meet the recommended dietary allowances<sup>1</sup>for this age group and to accommodate the taste preferences of young adult males. Overall, subjects found the meals to be satisfying and tasty. Monotony may have occurred during the 28-day feeding period because of the repetitious cycle and the highly controlled conditions. However, soy products are versatile, and only the imagination
Insulin vs Sulfonylureas for Second-Line Diabetes Treatment—Reply
Authors: Christianne L. Roumie, Robert A. Greevy, Marie R. Griffin
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Low absolute peripheral blood CD4+ T-cell count predicts poor prognosis in R-CHOP-treated patients with diffuse large B-cell lymphoma
Authors: Y Kusano, M Yokoyama, Y Terui, N Nishimura, Y Mishima, K Ueda, N Tsuyama, H Yamauchi, A Takahashi, N Inoue, K Takeuchi, K Hatake
Journal: Blood Cancer Journal (2017)

Correction to: Blood Cancer Journal (2017) 7, e558; doi:10.1038/bcj.2017.37; published online 21 April 2017 Following the online publication of this article, the authors noted an error in the author names: Dr Yamauchi's name was incorrectly spelled as Y Hirofumi. The complete and correct names and affiliations are: Y Kusano,1 M Yokoyama,1 Y Terui,1 N Nishimura,1 Y Mishima,1 K Ueda,1 N Tsuyama,2 H Yamauchi,1 A Takahashi,1 N Inoue,1 K Takeuchi,2,3 and K Hatake1
Commentaire du travail de Sacher-Huvelin S et al., pp. 486
Authors: Gilles Lesur, Maxime Palazzo, Nicolas Musquer, Marine Camus, Julien Branche
Journal: Endoscopy (2015)

See also: Screening of esophageal varices by esophageal capsule endoscopy: results of a French multicenter prospective studyEndoscopy 2015; 47(06): 486-492DOI: 10.1055/s-0034-1391393
Homeless
Authors: Frank Davidoff
Journal: Annals of Internal Medicine (2006)

On Being a Patient4 July 2006HomelessFrank Davidoff, MDFrank Davidoff, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-1-200607040-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail My mother, Ida, died a few years ago. By itself, her death could hardly be seen as a remarkable event. But the way she died was another matter altogether, because in the week before her death she was quite convinced she was already dead. Here's what happened.Well along in her 97th year, her body was failing in every way imaginable. The problem list? A virtual textbook of geriatric medicine: cataracts; hearing loss; a small lacunar brainstem stroke (vertigo, diplopia), which had knocked her walking, already shaky, down a notch. Third- degree heart block, pacemaker duly implanted; atrial fibrillation; left ...References1. Nuland SB. How We Die. Reflections on Life's Final Chapter. New York: Knopf; 1993. Google Scholar2. Christensen RC. Dead men walking. Reflections on Cotard's syndrome and homelessness. Pharos Alpha Omega Alpha Honor Med Soc. 2005;68:33-4. [PMID: 15792078] MedlineGoogle Scholar3. Pearn J, Gardner-Thorpe C. Jules Cotard (1840–1889): his life and the unique syndrome which bears his name. Neurology. 2002;58:1400-3. [PMID: 12011289] CrossrefMedlineGoogle Scholar4. Break Them Down. Systematic Use of Psychological Torture by US Forces. Washington, DC: Physicians for Human Rights; 2005:55. Google Scholar5. Hopper K, Baumohl J. Redefining the cursed word: a historical interpretation of American homelessness.. In: Baumohl J, eds. Homelessness in America. Phoenix, AZ: Oryx Pr; 1996:3. Google Scholar Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Frank Davidoff, MD, 143 Garden Street, Wethersfield, CT 06109; e-mail, [email protected]net. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCotard-Syndrom 4 July 2006Volume 145, Issue 1Page: 75-76KeywordsAntibioticsComputed axial tomographyDeliriumGeriatricsHand strengthHeartHemorrhageThoraxVertigoWalking ePublished: 4 July 2006 Issue Published: 4 July 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...