tbuckley/cabot-search huggingface dataset:
Outbreaks Associated with Treated Recreational Water — United States, 2000–2014
Authors: Michele C. Hlavsa, Bryanna L. Cikesh, Virginia A. Roberts, Amy M. Kahler, Marissa Vigar, Elizabeth D. Hilborn, Timothy J. Wade, Dawn M. Roellig, Jennifer L. Murphy, Lihua Xiao, Kirsten M. Yates, Jasen M. Kunz, Matthew J. Arduino, Sujan C. Reddy, Kathleen E. Fullerton, Laura A. Cooley, Michael J. Beach, Vincent R. Hill, Jonathan S. Yoder
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Outbreaks associated with exposure to treated recreational water can be caused by pathogens or chemicals in venues such as pools, hot tubs/spas, and interactive water play venues (i.e., water playgrounds). During 2000-2014, public health officials from 46 states and Puerto Rico reported 493 outbreaks associated with treated recreational water. These outbreaks resulted in at least 27,219 cases and eight deaths. Among the 363 outbreaks with a confirmed infectious etiology, 212 (58%) were caused by Cryptosporidium (which causes predominantly gastrointestinal illness), 57 (16%) by Legionella (which causes Legionnaires' disease, a severe pneumonia, and Pontiac fever, a milder illness with flu-like symptoms), and 47 (13%) by Pseudomonas (which causes folliculitis ["hot tub rash"] and otitis externa ["swimmers' ear"]). Investigations of the 363 outbreaks identified 24,453 cases; 21,766 (89%) were caused by Cryptosporidium, 920 (4%) by Pseudomonas, and 624 (3%) by Legionella. At least six of the eight reported deaths occurred in persons affected by outbreaks caused by Legionella. Hotels were the leading setting, associated with 157 (32%) of the 493 outbreaks. Overall, the outbreaks had a bimodal temporal distribution: 275 (56%) outbreaks started during June-August and 46 (9%) in March. Assessment of trends in the annual counts of outbreaks caused by Cryptosporidium, Legionella, or Pseudomonas indicate mixed progress in preventing transmission. Pathogens able to evade chlorine inactivation have become leading outbreak etiologies. The consequent outbreak and case counts and mortality underscore the utility of CDC's Model Aquatic Health Code (https://www.cdc.gov/mahc) to prevent outbreaks associated with treated recreational water.
The Estrogenicity of Bisphenol A-Related Diphenylalkanes with Various Substituents at the Central Carbon and the Hydroxy Groups
Authors: Pilar Perez, Rosa Pulgar, Fatima Olea-Serrano, Mercedes Villalobos, Ana Rivas, Manfred Metzler, Vicente Pedraza, Nicolas Olea
Journal: Environmental Health Perspectives (1998)

The chemical structure of hydroxylated diphenylalkanes or bisphenols consists of two phenolic rings joined together through a bridging carbon. This class of endocrine disruptors that mimic estrogens is widely used in industry, particularly in plastics. Bisphenol F, bisphenol A, fluorine-containing bisphenol A (bisphenol AF), and other diphenylalkanes were found to be estrogenic in a bioassay with MCF7 human breast cancer cells in culture (E-SCREEN assay). Bisphenols promoted cell proliferation and increased the synthesis and secretion of cell type-specific proteins. When ranked by proliferative potency, the longer the alkyl substituent at the bridging carbon, the lower the concentration needed for maximal cell yield; the most active compound contained two propyl chains at the bridging carbon. Bisphenols with two hydroxyl groups in the para position and an angular configuration are suitable for appropriate hydrogen bonding to the acceptor site of the estrogen receptor. Our data suggest that estrogenicity is influenced not only by the length of the substituents at the bridging carbon but also by their nature. Because diphenylalkane derivatives are widespread and their production and use are increasing, potential exposure of humans to estrogenic bisphenols is becoming a significant issue. The hazardous effects of inadvertent exposure to bisphenol-releasing chemicals in professional workers and the general populations therefore deserve investigation.
Educating patients about HIV
Authors: J. R. Thurn
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Physicians should play a major role in patient education. Primary care physicians, however, may express little interest in educating patients about human immunodeficiency virus (HIV).<sup>1</sup>Although there is some information on the provision of education about acquired immunodeficiency syndrome (AIDS) by general practitioners in Britain, there are few data in this regard about their colleagues in the United States. As part of a telephone survey of primary care physicians in Minnesota (in family medicine, general practice, and internal medicine), we asked questions designed to investigate this issue. A survey of short-answer, open-ended questions was administered to people from a random selection of offices. Small offices were considered to have one to five physicians and large offices to have more than five physicians. Responses were obtained from representatives of 83.4% (141/169) of physicians' offices contacted. Most nonresponses (15 of 28) occurred because a person able to respond
The Informationist
Authors: Michael J. Schott
Journal: Annals of Internal Medicine (2001)

Letters6 February 2001The InformationistMichael J. Schott, MS, MLSMichael J. Schott, MS, MLSWest Virginia University; Charleston, WV 25304 (Schott)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I commend Davidoff and Florance for their editorial on the future of medical literature access (1). I was a “clinical librarian” for 12 years at a Connecticut hospital, following in the footsteps of such greats as Gertrude Lamb (2). As subsequent studies have shown, rapid delivery of medical information by a trained clinical librarian regularly interacting with physicians has immense practical value to the patient (3-5).Two points covered in Davidoff and Florance's editorial need to be expanded upon: It is a dirty little secret that hospital libraries are dying. Managed care, health maintenance organizations, cuts in ...References1. Davidoff F, Florance V. The informationist: a new health profession? [Editorial]. Ann Intern Med. 2000;132:996-8. LinkGoogle Scholar2. Arcari R, Lamb G. The librarian in clinical care. Hosp Med Staff. 1977;6:18-23. MedlineGoogle Scholar3. Barbour GL, Young MN. Morning report. Role of the clinical librarian. JAMA. 1986;255:1921-2. CrossrefMedlineGoogle Scholar4. King DN. The contribution of hospital library information services to clinical care: a study in eight hospitals. Bull Med Libr Assoc. 1987;75:291-301. MedlineGoogle Scholar5. Klein MS, Ross FV, Adams DL, Gilbert CM. Effect of online literature searching on length of stay and patient care costs. Acad Med. 1994;69:489-95. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: West Virginia University; Charleston, WV 25304 (Schott) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Informationist: A New Health Profession? Frank Davidoff and Valerie Florance The Informationist Frank Davidoff and Valerie Florance The Informationist Deborah B. Root Jorgensen The Informationist Stephen Sandroni The Informationist Bruce Houghton and Eugene C. Rich Metrics Cited byWorking towards the informationist 6 February 2001Volume 134, Issue 3Page: 252KeywordsComputersForecastingHealth maintenance organizationsInformation retrievalLibrariesResidencyRunning ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Reply
Authors: Yasuko Iwakiri
Journal: Hepatology (2017)

Potential conflict of interest: Nothing to report. Reply: I thank Drs. Arrive and Mouhadi for their letter expressing interest in my commentary on the lymphatic system in the liver that appeared in the September issue1 and for sharing their clinical observations of dilated hepatic lymphatic vessels in patients with portal hypertension using noncontrast, heavily T2‐weighted, three‐dimensional magnetic resonance imaging. Clinical observations of lymphatic vessel changes in liver diseases are indispensable for our understanding of the hepatic lymphatic system, and Drs. Arrive and Mouhadi have highlighted a useful technique for evaluating lymphatic vessel morphology in this setting. One question that occurs to me is how the vessels shown in the figures were identified as lymphatic vessels from complex vascular networks in the liver without contrast agents. Their observations of dilated hepatic lymphatic vessels in patients with portal hypertension are interesting. Previously, increased levels of endothelial nitric oxide (NO) synthase were observed in mesenteric lymphatic vessels from rats with cirrhosis and ascites.2 Given that endothelial NO synthase is the primary source of NO (a potent vasodilator) in endothelial cells, this leads to the hypothesis that mesenteric lymphatic vessels in rats with cirrhosis are dilated as well. However, one must also consider that NO production decreases in the hepatic sinusoidal circulation in cirrhosis with portal hypertension, contributing to increased resistance to portal blood flow. These observations lead to questions as to whether NO is involved in dilation of lymphatic vessels or whether NO production differs between the sinusoidal circulation and hepatic lymphatic vessels in cirrhosis with portal hypertension. Overall, little is known about the regulation of hepatic lymphatic vessels in normal and pathological conditions.3 A combination of clinical observations using noninvasive technologies such as magnetic resonance systems and elucidation of molecular mechanisms in experimental models of liver diseases will significantly advance our understanding in this area. As far as I know, in vivo imaging technologies to identify hepatic lymphatic vessels in small animals are not currently available. Such imaging is challenging, particularly in the liver, because it requires special contrast agents that enable visualization of small lymphatic vessels with high resolution while distinguishing them from hepatic arteries and veins. These technologies are eagerly awaited.
Section 22.—Whipple's Disease
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fatal and Nonfatal Suicide Attempts Among Adolescents—Oregon, 1988-1993
Journal: JAMA (1995)

Suicide is the third leading cause of death among adolescents aged 15-19 years in the United States and second among adolescents in Oregon. During 1959-1961 and during 1990-1992, the rate of suicide in Oregon increased sixfold among 15-19-year-olds. During 1988-1991, the suicide rate for adolescents in Oregon (15.5 deaths per 100,000) was 39.6% higher than the U.S. rate (11.1). Because of the magnitude of this problem, in 1987 the state legislature in Oregon mandated that hospitals treating a child aged < or = 17 years for injuries resulting from a suicide attempt report the attempt to the State Health Division, Oregon Department of Human Resources, and that the patient be referred for counseling; the Oregon Adolescent Suicide Attempt Data System (ASADS) was established in 1988. This report presents an analysis of data for adolescents aged < or = 17 years from ASADS during 1988-1993.
From the National Institutes of Health
Authors: James B. Wyngaarden
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deposition and clearance of inhaled particles.
Authors: B O Stuart
Journal: Environmental Health Perspectives (1976)

Theoretical models of respiratory tract deposition of inhaled particles are compared to experimental studies of deposition patterns in humans and animals, as determined principally by particle size, density, respiratory rate and flow parameters. Various models of inhaled particle deposition make use of convenient approximations of the respiratory tract to predict tractional deposition according to fundamental physical processes of impaction, sedimentation, and diffusion. These theoretical models for both total deposition and regional (nasopharyngeal, tracheobronchial, and pulmonary) deposition are compared with experimental studies of inhaled dusts in humans or experimental animals that have been performed in many laboratories over several decades. Reasonable correlation has been obtained between theoretical and experimental studies, but the behavior of very fine (less than 0.01 mum) particles requires further refinement.Properties of particle shape, charge, and hygroscopicity as well as the degree of respiratory tract pathology also influence deposition patterns and further experimental work is urgently needed in these areas. The influence upon deposition patterns of dynamic alterations in inspiratory flow profiles caused by a variety of breathing patterns also requires further study, and the use of such techniques with selected inhaled particle size holds promise in possible diagnostic aid in diagnosis of normal versus disease conditions. Mechanisms of conducting airway and alveolar clearance processes involving mucociliary clearance, dissolution, transport to systemic circulation, and translocation via regional lymphatic clearance are discussed. The roles of the pulmonary macrophage in airway and alveolar clearance are described, and the applicability of recent solubility models for translocation or deposited materials to liver, skeleton, or other systemic organs is discussed.
Correction: Arthroscopic surgery compared with supervised exercises in patients with rotator cuff disease (stage II impingement syndrome)
Journal: BMJ (1993)

from Europe and the United Kingdom that the rate of complication of the laparoscopic method is at least as good as that of open cholecystectomy if not better.A recently published American review of 77600 cases reported that laparotomy for the treatment of a complication was required by 1-2% of patients.4The mean rate of bile duct injury was 0-6%, and these injuries occurred mainly during the first 100 cases.Postoperative bile leak was recognised in 0 3%, and only 18 of the 33 postoperative deaths resulted from operative injury.Furthermore, the long term rate of complication was reduced by the low number of complications associated with the wound, such as infection and incisional hernia.As already mentioned, patients return to work much more rapidly than after open surgery.
Stro-1 Positive and Stro-1 Negative Human Mesenchymal Stem Cells Express Different Levels of Immunosuppression.
Authors: Sabine Francois, Yizhuo Zhang, Morad Bensidhoum, Christelle Mazurier, Aisha Nasef, Sandrine Bouchet, Noelle Mathieu, Norbert-Claude Gorin, Manuel Lopez, Michel Bourgeade, Dominique Thierry, Alain Chapel, Loic Fouillard
Journal: Blood (2005)
Diabetes mellitus--problems of keto-acidosis.
Journal: BMJ (1972)

About one-quarter of all diagnosed diabetics are dependent on insulin and it is usually such patients that are seen in hospital when the control of blood sugar is lost.Many students find difficulty in grasping the principles of insulin therapy.Diabetic Keto-acidosis and Infection HOUSE PHYSICIAN: This 15-year-old boy was admitted one week ago in a stuporose state.In the four days before admission he had had a 'flu-like illness and had then developed intense thirst, polyuria, lassitude, and finally breathlessness.The blood pressure was 95/50 mm Hg.He was dehydrated and smelled of ketones.The urine contained over 2% of glucope (Clinitest- Ames) and ketonuria to both Acetest (Ames) and ferric chloride.There was no past history of diabetes mellitus.DR.R. A. WOOD: Certain investigations are required immedia- tely in such cases.While an intravenous route is being estab- lished, venous blood must be taken for measuring blood glucose, urea, electrolytes, and carbon dioxide combining power, and for cross-matching.In the more severe cases an arterial sample should be taken for estimating arterial oxygen content and pH.In this boy the diagnosis of diabetic keto-acidosis was not in doubt and he required insulin and replacement fluid therapy urgently.
A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
Authors: Ke Huang, Qian Liang, Ye Zhou, Lu-lu Jiang, Wei-ming Gu, Ming-yu Luo, Ya-bin Tang, Yang Wang, Wei Lu, Min Huang, Sheng-zhe Zhang, Guang-lei Zhuang, Qing Dai, Qian-cheng Shen, Jian Zhang, Hui-min Lei, Liang Zhu, De-yong Ye, Hong-zhuan Chen, Lu Zhou, Ying Shen
Journal: Cell Metabolism (2021)
Hydrogen Infusion: Heart Output Guide
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE FEMALE ATHLETE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Skin Grafts Upon the Heart: Effect on Intercoronary Blood Flow
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arch Biochemistry and Biophysics, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal