tbuckley/cabot-search huggingface dataset:
Physician's guide to air pollution episodes
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
APPROVED INTERNSHIPS
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contact dermatitis due to formaldehyde in clothing textiles
Authors: S. E. O'Quinn
Journal: JAMA (1965)

Formaldehyde resins are widely used in the textile industry in textile finishing. Many wrinkle-proof, creaseresistant, and waterproof fabrics have been treated in this manner. Contact dermatitis due to formaldehyde contained in textiles has been reported from the European countries but no authenticated cases have been reported in the United States. This report describes three patients with allergic contact dermatitis due to formaldehyde contained in wearing apparel. The patients had positive patch tests to formaldehyde and to samples of textiles shown by chemical analysis to contain formaldehyde. There was correlation between the outbreaks of dermatitis and the use of formaldehyde-containing fabrics.
The acquired resistance to the combination of the anti-EGFR cetuximab and the MEK-inhibitor refametinib in KRAS mutated colorectal cancer cell lines depends on PI3K-signalling
Authors: P.P. Vitiello, G. Viscardi, G. Martini, C. Cardone, D. Ciardiello, V. Belli, N. Matrone, T. Troiani, S. Napolitano, V. Sforza, V. De Falco, E. Giunta, F. Morgillo, M.R. Diadema, P. Vitale, N. Zanaletti, F. Ciardiello, E. Martinelli
Journal: Annals of Oncology (2017)
The role of increasing detection in the rising incidence of prostate cancer
Authors: A. L. Potosky
Journal: JAMA (1995)

<h3>Objective.</h3> —To assess the reasons for the dramatic surge in prostate cancer incidence from 1986 to 1991. <h3>Design.</h3> —Population-based study of incidence rates and procedures used to detect and diagnose prostate cancer derived from Medicare claims data and the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program from 1986 to 1991. <h3>Setting.</h3> —Four SEER areas (Connecticut; Atlanta, Ga; Detroit, Mich; and Seattle—Puget Sound, Wash) covering approximately 6% of the US population. <h3>Participants.</h3> —A 5% random sample of male fee-for-service Medicare beneficiaries aged 65 years and older without cancer, and all men with prostate cancer diagnosed at 65 years of age and older residing in the four areas. <h3>Main Outcome Measures.</h3> —The age-adjusted rates of prostate cancer incidence, prostate needle biopsy, transurethral resection of the prostate, serum prostate-specific antigen (PSA) testing, and transrectal ultrasound. <h3>Results.</h3> —The age-adjusted incidence rate of prostate cancer among men aged 65 years and older in the four SEER areas rose 82% from 1986 to 1991, with the largest annual increases occurring in 1990 (20%) and 1991 (19%). Prostate needle biopsy rates increased while the use of transurethral resection of the prostate declined from 1986 to 1991. The rising needle biopsy rate has been driven by an exponential increase in PSA testing in the general population from 1988 to 1991 and, to a much lesser extent, the increasing use of transrectal ultrasound since 1986. The use of PSA or transrectal ultrasound has increased across age and race groups and in different geographic areas. However, there remain wide geographic variations in the use of PSA screening. <h3>Conclusions.</h3> —The recent dramatic epidemic of prostate cancer is likely the result of the increasing detection of tumors resulting from increased PSA screening. The magnitude and rapidity of the incidence rise suggest that changes in the intensity of medical surveillance is the most plausible explanation for this trend. <h3>Implications.</h3> —The rapid diffusion of screening interventions that have the ability to detect latent asymptomatic disease leads to important concerns regarding costs and patient quality of life for men aged 65 years and older. Geographic variability in the adoption of PSA testing underscores uncertainty and disagreement about its value for reducing prostate cancer mortality. More research is required to determine the effectiveness of screening for prostate cancer. (<i>JAMA</i>. 1995;273:548-552)
Red Blood Cell Transfusions Contaminated With Yersinia enterocolitica—United States, 1991-1996, and Initiation of a National Study to Detect Bacteria-Associated Transfusion Reactions
Journal: JAMA (1997)

Although bacteremia and sepsis are infrequently reported complications of red blood cell (RBC) transfusion, receipt of transfused blood contaminated with bacterial pathogens may result in sepsis, disseminated intravascular coagulation, and death. Such pathogens have included Yersinia enterocolitica and Pseudomonas fluorescens. From November 1985 through February 1991, a total of 11 cases of sepsis associated with receipt of transfused Y. enterocolitica-contaminated RBCs were reported in the United States. This report describes an additional 10 cases of Y. enterocolitica sepsis reported to CDC during March 1991-November 1996 in patients who received transfusions with contaminated RBCs and describes the development of a study to detect bacteria-associated reactions to transfusion of RBCs and other blood components.
Extending Brady Background Checks Opposed
Authors: T. Cole
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE STAT SIGNALING BIOSIGNATURE OF CD4+ T CELL SUBSETS REFLECT THE IMMUNOGENICITY OF HIGH-RISK MDS AND PREDICT AZACYTIDINE TREATMENT OUTCOME
Authors: E. Lamprianidou, C. Kordella, E. Zoulia, M. Papoutselis, Z. Bezirgiannidou, G. Vrachiolias, E. Spanoudakis, T. Vassilakopoulos, A. Galanopoulos, S. Papageorgiou, V. Pappa, S. Vakalopoulou, V. Garipidou, M. Papaioannou, E. Hatjiharissi, P. Diamantopoulos, N.-A. Viniou, I. Kotsianidis
Journal: HemaSphere (2019)
HOPE (generic)
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II pilot results of imatinib mesylate with weekly docetaxel in metastatic breast cancer
Authors: D. M. Waterhouse, M. Mainwaring, J. Barton, C. Webb, T. M. Markus, D. R. Spigel, J. R. Infante, J. D. Hainsworth, F. A. Greco, D. A. Yardley
Journal: Journal of Clinical Oncology (2008)

1090 Background: Imatinib mesylate (G) is a potent tyrosine kinase inhibitor of platelet derived growth factor receptor (PDGFR), c-KIT, and bcr/abl. PDGFR signaling regulates interstitial tumor pressure enhancing tumor drug delivery and effects. This phase II pilot evaluates the feasibility, toxicity, and efficacy of imatinib with weekly docetaxel as a strategy to potentiate docetaxel in metastatic breast cancer (MBC). Methods: Eligibility: 0–1 regimens for MBC, > 6 months from prior adjuvant taxanes, measurable disease, ECOG PS 0–2, adequate organ function, < G2 neuropathy. Treatment: Docetaxel 30 mg/m2 IV days 1, 8 and 15 q28 with G 600 mg QD. After the first 14 pts, G was decreased to 400 mg in the remaining 19 pts. Response evaluations were every q 8 wks. Following 6 cycles of therapy, pts with SD or better continued maintenance G until PD. Results: 33 pts are evaluable for toxicity. Median age 58 (38–82), ECOG PS 0–18, PS 1–14 pts. 49% ER-/PR- and 79% HER2 neg. 61% had metastases in > 2 visceral sites with lung predominating 42%. 55% received therapy 1st line and 42% as 2nd-line. 13 pts had prior taxanes of which 70% were treated 2nd-line. Hematologic toxicity was mild with G3/4 neutropenia 12%, anemia 9%; 1 pt with febrile neutropenia. G3/4 nonhematologic toxicity consisted of fatigue 27% and GI toxicity prompting G dose modification to 400 mg after the first 14 pts. Despite the lower G dose, the GI events remained distributed equally between the 600/400 mg G doses: G3/4 diarrhea 21% (4/3), nausea 18% (4/2), vomiting 12% (2/3), anorexia 6% (1/1) 22 pts required hospitalizations, 9 treatment related (GI toxicity 4, febrile neutropenia 1, pleural effusion 2, pneumonia 2), 2 other, and 11 due to progression. Median # of cycles was 3 (1.5 - 12.5). 5 pts went on to maintenance G with a median of 6 cycles and 2 remain on maintenance G. 4 of 18 evaluable pts (12%) had PRs, 8 pts had SD, and 6 pts progressed. 11 pts were not evaluable and responses unknown in 4 pts. Median time to progression and overall survival were 3 and 10 months respectively. Conclusions: Imatinib with docetaxel is associated with significant GI toxicity, despite G dose modification to 400 mg daily. No therapeutic advantage for the addition of imatinib to weekly docetaxel in MBC was evident. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Bayer, Genentech Bristol-Myers Squibb, Eli Lilly and Company, Genentech, GlaxoSmithKline, GPC Biotech, Novartis, sanofi-aventis
Reducing Medical Facilities
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Orthopedic Surgery
Authors: Robert W. Bucholz
Journal: JAMA (1996)

The research focus of orthopedic surgery during the past few years has shifted from its traditional mechanical emphasis to the biologic basis for the growth, development, and repair of musculoskeletal tissues. New technologies offer investigators previously unavailable tools for studying and manipulating the physiological cascade of cellular and chemical events responsible for bone and cartilage healing. A host of different proteins from the transforming growth factor β (TGF-β) superfamily have been found to induce bone repair by stimulating the phenotypic expression of undifferentiated mesenchymal cells.<sup>1</sup>One such protein, bone morphogenetic protein 2 (produced by recombinant technology), was found to be as effective as autogenous bone graft in healing of a 2.5-cm femoral defect in a sheep model.<sup>2</sup>Similar stimulatory effects of various local growth factors on the healing of critical-sized defects have been documented in other animal models.<sup>3</sup>Even more promising is the apparent effect of these
Haemophilus influenzae meningitis in school-aged children
Authors: P. R. Wood
Journal: JAMA (1982)

The relative frequency of meningitis caused by<i>Haemophilus influenzae</i>in school-aged children was determined by reviewing etiologic diagnoses in children 6 to 15 years old admitted to four hospitals from 1974 to 1978. Sixty-five (45%) of 145 patients had aseptic meningitis and 29 (20%) had bacterial meningitis. Thirty-two (22%) of the patients had received antibiotic therapy before diagnosis, and 19 (13%) could not be classified. Six (21%) of the 29 patients with bacterial meningitis had H<i>influenzae</i>meningitis. Although aseptic disease was the most common type of meningitis, initial antibiotic therapy for presumed bacterial meningitis in school-aged children should include adequate coverage for<i>H influenzae</i>. (<i>JAMA</i>1982;247:1162-1163)
THE ACTION OF RADIUM ON CANCER.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antihemophilic factor concentrate therapy in von Willebrand disease. Dissociation of bleeding-time factor and ristocetin-cofactor activities
Authors: P. M. Blatt
Journal: JAMA (1976)

Treatment of von Willebrand disease with two plasma antihemophilic factor (AHF) concentrates, cryoprecipitate and glycine-precipitated AHF, was compared. Both concentrates were equally effective in immediately raising the plasma levels of factor VIII, the factor VIII-related antigen, and the ristocetin-related von Willebrand factor (vWF) and in stimulating a secondary rise in plasma factor VIII. Given either concentrate, the vWF activity, the antigen, and factor VIII levels were normalized in a patient with von Willebrand disease. However, correction of the prolonged bleeding time and control of bleeding occurred only with the cryoprecipitate. The bleeding-time corrective factor and the ristocetin-related vWF or platelet-aggregating factor are dissociable, distinct activities. (<i>JAMA</i>236:2770-2772, 1976)
Helping the dying to live—through hypnosis
Authors: Jack Martin
Journal: JAMA (1983)

Hospital—or hypnosis? That is a choice some terminally ill patients are making, and hypnosis can be the far better alternative, says Wallace L. LaBaw, MD, of Denver, who has treated dozens of such patients over the past decade. He tells of the woman, for example, who "drove her little daughter to the shopping center, picked up some groceries at the Safeway, and then went home and died, alert and feeling like a useful wife and mother to the very end." LaBaw continues, "Many patients, when placed in a hospital, feel abandoned. Physicians are too often inclined to mark time in quiet desperation or to indulge in desperate heroics with these patients. I've done it myself. Certainly, some patients have to be in the hospital at some time, but many do not—we keep them there because we don't want them to think we're not doing anything as doctors." LaBaw, a former
Dermabrasion
Authors: Stephen Kurtin
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Dr. Ervin Epstein's "Present Status of Dermabrasion" (<b>206</b>:607, 1968) states that dermabrasion can no longer be considered a useful means for the treatment of acne scars. Most of the complications that Dr. Epstein cites: bleeding, pain, erythema, infection, and milia are infrequent or transient. The problem of scarring is rare and only results if improper technique is used. The major complications are pigmentary disturbances, which are fortunately uncommon, and the result of over-exposure to sunlight, especially when the exposure occurs shortly after the dermabrasion. No one will deny that acne scars can be disfiguring and can cause severe psychological consequences. Even the most enthusiastic supporters of dermabrasion will admit that perfect results cannot be attained, but this is no reason to discard a procedure which can achieve a marked cosmetic improvement. Because of the less than perfect results from dermabrasion, some of the initial enthusiasm for
Vital Signs
Authors: Bernadine Z. Paulshock
Journal: JAMA (1991)

Imagination is "an ingredient as necessary to poetry as rhythm and active language,"<sup>1</sup>led off a recent article on poetry in<i>The New Yorker</i>. And in an article entitled "Can Poetry Matter?" Gioia declared, "American poetry now belongs to a subculture," and "[is] no longer part of the mainstream of artistic and intellectual life."<sup>2</sup>Both authors would, I think, appreciate the effort behind this little book, which includes poems with titles like "Janet Was Stabbed" by James W. Voell, MD, "Spinal Anesthesia" by Bert Hirschhorn, MD, and "Psychiatric Consult on an Anorectic Girl With Long Hair" by Eric K. Bonsall, MD. In his poem Bonsall says his patient "sips from her IV" and tells her, "Your chart is thick with your thinness" but "does not contain the tears." Nine of the 40 poets represented have had their poems published before, primarily in medical journals. It's truly wonderful that
Diagnostic Tests
Journal: JAMA (2001)

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