tbuckley/cabot-search huggingface dataset:
Magazine, Radio and TV Report Magazines
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adverse Drug Events in Hospitalized Patients
Authors: James Joseph Rybacki
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The articles by Dr Classen et al,<sup>1</sup>Dr Bates et al,<sup>2</sup>and Dr Lesar et al<sup>3</sup>are all excellent in their own right. The problem is that they appear at all. If we look back to 1995, we find an article by Leape et al<sup>4</sup>that outlines a systems analysis of adverse drug events (ADEs). Clearly it is one thing to analyze a problem and quite another to put acceptable solutions to work. I strongly agree that quality improvement teams and simplified systems are part of the answer, yet I believe that the extreme care needed to make certain that patients understand their condition and its treatment is not being taken. Placing the financial burden at $136 billion should open some eyes, and, of course, the human toll is unconscionable. At our clinic, we now take the time to develop a printed schedule detailing when and
Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor
Authors: D Jung
Journal: Gut (2003)

<b>Background:</b> Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (<i>SLC10A2</i>). In rats, ASBT is induced by glucocorticoids. <b>Aims:</b> To study whether human ASBT is activated by glucocorticoids and to elucidate the mechanism of regulation. <b>Patients and methods:</b> ASBT expression in ileal biopsies from patients with Crohn's disease and from healthy subjects was quantified by western blot. ASBT promoter function was studied in luciferase assays and by electrophoretic mobility shift assay. <b>Results:</b> In 16 patients with Crohn's disease, ASBT expression was reduced to 69 (7.5)% compared with healthy controls (mean (SEM); p = 0.01). In 10 healthy male volunteers, ASBT protein expression was increased 1.34 (0.11)-fold (mean (SEM); p&lt;0.05) after 21 days' intake of budesonide (9 mg/day) whereas expression of the peptide transporter 1 was unaffected. Reporter constructs of the human ASBT promoter were activated 15–20-fold by coexpression of the glucocorticoid receptor (GR) and exposure to the GR ligands dexamethasone or budesonide. Two glucocorticoid response elements in the ASBT promoter, arranged as inverted hexanucleotide repeats (IR3 elements), conferred inducibility by GR and dexamethasone in a heterologous promoter context and were shown to bind GR in mobility shift assays. <b>Conclusions:</b> Human ASBT is induced by glucocorticoids in vitro and in vivo. Induction of ASBT by glucocorticoids could be beneficial in patients with Crohn's disease who exhibit reduced ASBT expression. This study identifies ASBT as a novel target of glucocorticoid controlled gene regulation in the human intestine.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1961)

COMMITTEE ON MATERNAL AND PERINATAL WELFARE*Aspiration PneumonitisAfter an uneventful prenatal course, a twenty-year-old gravida 1 was admitted to the hospital at term about 9 p.m. Labor had begun about 2 p.m., but at 7 o'clock the patient had had a piece of chocolate-cream pie and a cup of tea. Contractions were now three minutes apart, the membranes intact, the cervix 1 cm. dilated, the vertex at mid-station, and the vital signs normal. Medication given at 10:10 and 10:40 totaled 200 mg. of secobarbital (Seconal), 50 mg. of meperidine (Demerol), 25 mg. of promethazine hydrochloride (Phenergan Hydrochloride) and 0.4 . . .
Prevalence and Prognostic Impact of Allelic Imbalances Associated with Leukemic Transformation of Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.
Authors: Nils Heinrich Thoennissen, Utz O. Krug, Dhong Hyun Lee, Norohiko Kawamata, Terra L Lasho, Tamara Weiss, Daniel Nowak, Gabriela B. Iwanski, Motohiro Kato, Lee-Yung Shih, Maya Koren-Michowitz, Arnon Nagler, Sophie Raynaud, Carsten Müller-Tidow, Ruben A. Mesa, Torsten Haferlach, D. Gary Gilliland, Ayalew Tefferi, Seishi Ogawa, H. Phillip Koeffler
Journal: Blood (2009)
ANOTHER JUDGE DEFINES PRACTICE OF MEDICINE.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bronchogenic carcinoma with invasion of the spine. Treatment with combined surgery and perioperative brachytherapy
Authors: D. Nori
Journal: JAMA (1982)

A 64-year-old man with bronchogenic carcinoma was noted to have invasion of the chest wall and spine at time of diagnosis. Computed tomography and myelography demonstrated destruction of the vertebral body with epidural extension. After preoperative radiotherapy, resection of the involved lung, chest wall, and spine was accomplished. Afterloading catheters were placed for tumor-bed perioperative iridium 192 irradiation. The patient is free of disease two years after treatment. We describe the afterloading perioperative brachytherapy technique used and suggest this multidisciplinary approach for bronchogenic carcinoma invading the spine. (<i>JAMA</i>1982;248:2491-2492)
Administration attacks increasing use of marijuana
Authors: C. Marwick
Journal: JAMA (1995)

MARIJUANA use among adolescents has increased substantially during the past 3 years. Nearly one third (30.7%) of high school seniors surveyed recently said they smoked marijuana at least once in the past year compared with 26% in 1993 and 21.9% in 1992. The recent increase has been most marked among eighth graders, among whom it has doubled since 1991. The survey is one that has been conducted annually among adolescents since 1975 by Lloyd D. Johnston, PhD, acting director of the Substance Abuse Center at the University of Michigan, Ann Arbor, for the National Institute on Drug Abuse (NIDA). At the same time, figures recently released indicate that 30% more teenagers were smoking cigarettes in 1994 compared with 1991. Although cigarettes are legal, in the view of experts in the field both of these developments are ominous, since it means there is an expanding pool of young people willing to
Physician Payments
Authors: Mike Mitka
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trichophyton tonsurans tinea capitis
Authors: E. Prevost
Journal: JAMA (1980)

<h3>To the Editor.—</h3> In regard to my article in<i>JAMA</i>(242:1765, 1979) and the accompanying editorial by Andrew H. Rudolph, MD (242:1770, 1979), concerning<i>Trichophyton tonsurans</i>tinea capitis, I recently had the opportunity to review the charts of 40 children with culturally proved<i>T tonsurans</i>scalp infections. Of these, 30 (75%) were originally misdiagnosed by the primary care physician (pediatrician, family practitioner) as chronic dandruff, impetigo, and seborrhea. After various prescribed treatments (dandruff and medicated shampoos, erythromycin, and tetracycline) with little or no improvement (in one case as long as two years of chronic flaking and hair loss), a culture was finally taken, and the problem resolved with griseofulvin therapy. This finding illustrates the difficulty in diagnosing these infections. Our dermatologists have suggested that all scalp problems in children should be considered tinea capitis until culturally proved otherwise.
Upper gastrointestinal hemorrhage
Authors: E. D. Palmer
Journal: JAMA (1975)

AS one of the more desperate of medical emergencies, torrential upper gastrointestinal hemorrhage demands close teamwork between several medical workers: clinicians, nurses, radiologists, laboratory technicians, electrocardiographers, blood bank personnel, and chaplains. Because each may have an urgent job very soon after the patient arrives on the medical scene, a prescribed plan of action for immediate treatment is required if confusion and inefficiency are to be avoided. On the other hand, the many clinical variables encountered among bleeding patients, particularly as they pertain to the preexisting base line medical situation, necessitate the most thoughtful individualization in the treatment of each patient. In upper gastrointestinal hemorrhage the bleeding source lies somewhere proximal to the third portion of the duodenum. Thus, by definition, the source of upper gastrointestinal hemorrhage may be reached by routine peroral panendoscopy. This is an especially important point: it explains why arteriography is ordinarily not employed for diagnosis, even
P09.01 Phase I/II Study of Temozolomide Plus Nimustine Chemotherapy for Recurrent Malignant Gliomas: Kyoto Neuro-oncology Group
Authors: T. Aoki, None Arakawa, None Ueba, None Oda, None Nishida, None Akiyama, None Tsukahara, None Iwasaki, None Mikuni, None Miyamoto
Journal: Neuro-Oncology (2017)

The objective of this phase I/II study was to examine the efficacy and toxicity profile of temozolomide (TMZ) plus nimustine (ACNU). Patients who had received a standard radiotherapy with one or two previous chemo-regimens were enrolled. In phase I, the maximum-tolerated dose (MTD) by TMZ (150 mg/m2/day) (Day 1-5) plus various doses of ACNU (30, 35, 40, 45 mg/m2/day) (Day 15) per 4 weeks was defined on a standard 3 + 3 design. In phase II, these therapeutic activity and safety of this regimen were evaluated. Forty-nine eligible patients were enrolled. The median age was 50 years-old. Eighty percent had a KPS of 70-100. Histologies were glioblastoma (73%), anaplastic astrocytoma (22%), anaplastic oligodendroglioma (4%). In phase I, 15 patients were treated at four cohorts by TMZ plus ACNU. MTD was TMZ (150 mg/m2) plus ACNU (40 mg/m2). In phase II, 40 patients were treated at the dose of cohort 3 (MTD). Thirty-five percent of patients experienced grade 3 or 4 toxicities, mainly hematologic. The overall response rate was 11% (4/37). Sixty-eight percent (25/37) had stable disease. Twenty-two percent (8/37) showed progression. Progression-free survival (PFS) rates at 6 and 12 months were 24% (95% CI, 12-35%) and 8% (95% CI, 4-15%). Median PFS was 13 months (95% CI, 9.2-17.2 months). Overall survival (OS) at 6 and 12 were 78% (95% CI, 67-89%) and 49% (95% CI, 33-57%). Median OS was 11.8 months (95% CI, 8.2-14.5 months). This phase I/II study showed a moderate toxicity in hematology and may has a promising efficacy in OS, without inferiority in PFS. Neurologia medico-chirurgica Advance Publication Date: October 11, 2016 doi: 10.2176/nmc.oa.2016-0162
Directory of Catholic Hospitals and Allied Agencies of the United States and Canada, 1935
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebral Palsy
Authors: Eric Denhoff, Victor N. Smirnoff, Raymond H. Holden
Journal: New England Journal of Medicine (1951)

CEREBRAL palsy, formerly known as spastic paralysis, is a term that has been popularized recently through the concerted efforts of various organizations interested in providing medical and social service to patients and in stimulating research concerning this disorder. These patients represent the second largest group of crippled children in the country, cerebral palsy being next to poliomyelitis in incidence.1 It is currently emphasized that cerebral palsy is no longer to be considered a hopeless condition, but rather that some measure of rehabilitation can be achieved by a majority of patients if the proper facilities are provided. During the past five . . .
Mutations in the vasopressin V2 receptor and aquaporin-2 genes in 12 families with congenital nephrogenic diabetes insipidus.
Authors: R Vargas-Poussou, L Forestier, M D Dautzenberg, P Niaudet, M Déchaux, C Antignac
Journal: Journal of the American Society of Nephrology (1997)

Congenital nephrogenic diabetes insipidus (CNDI) is a rare inherited disorder characterized by renal tubular insensitivity to the antidiuretic effect of arginine vasopressin (AVP). In a large majority of the cases, nephrogenic diabetes insipidus is an X-linked recessive disorder caused by mutations in the AVP V2 receptor gene (AVPR2). In the remaining cases, the disease is autosomal recessive or dominant and, for these patients, mutations in the aquaporin 2 gene (AQP2) have been reported. Fourteen probands belonging to 12 families were analyzed by single-strand conformational polymorphism and direct sequencing of the AVPR2 and AQP2 genes. Ten mutations of the AVPR2 gene (six previously reported mutations and four novel mutations: G107E, W193X, L43P, and 15delC) were identified. Three mutations of the AQP2 gene were also identified in two patients: the first patient is homozygous for the R85X mutation and the second is a compound heterozygote for V168 M and S216P mutations. Extrarenal responses to infusion of the strong V2 agonist 1-desamino-8-D-arginine vasopressin allowed AVPR2- and AQP2-associated forms of CNDI to be distinguished in three patients. This test also identified an unexpectedly high urinary osmolality (614 mosmol/kg) in a patient with a P322S mutation of AVPR2 gene and a mild form of CNDI.
Nosocomial Poisoning Associated With Emergency Department Treatment of Organophosphate Toxicity—Georgia, 2000
Journal: JAMA (2001)

Emergency department (ED) staff caring for patients contaminated with toxic chemicals are at risk for developing toxicity from secondary contamination. This report describes three cases of occupational illnesses associated with organophosphate toxicity caused by exposure to a contaminated patient and underscores the importance of using personal protection equipment (PPE) and establishing and following decontamination procedures in EDs and other areas of acute care hospitals.
Local Transmission of Plasmodium vivax Malaria—Houston, Texas, 1994
Journal: JAMA (1995)

Malaria was endemic in the United States until the late 1940s; since then, most cases of malaria reported in the United States has been acquired during international travel or has occurred in persons who had resided in countries where malaria is endemic. This report summarizes the investigation of three persons who acquired Plasmodium vivax infection in Houston, Texas, by presumed mosquitoborne transmission during 1994.
The Gamma Globulins
Authors: Chester A. Alper, Fred S. Rosen, Charles A. Janeway
Journal: New England Journal of Medicine (1966)

ADVANCES in the study of the serum proteins over the past several years have been so extensive that the very term "hypergammaglobulinemia" has a different meaning now from the one it had when first introduced. It is clear that not all antibody molecules have gamma (or "slow") electrophoretic mobility. The recognition that antibody molecules form a family of structurally related species, termed immunoglobulins by Hitzig178 and Heremans,179 has, in essence, expanded the meaning of the term "hypergammaglobulinemia" into "hyperimmunoglobulinemia." We shall use the older designation in the modern sense in this review.Hypergammaglobulinemia is a common finding in a wide . . .
Analysing clubs' "amnesty bins" is beneficial
Journal: BMJ (2001)

Pelvic floor exercises help prevent postnatal incontinenceAdvice and training in pelvic floor exercises and bladder control can reduce the incidence of persistent urinary incontinence after childbirth.Postnatal urinary incontinence affects around 30% of women and, without treatment, can persist for at least a year in two thirds of them.In a large randomised controlled trial of conservative management provided by nurses Glazener and colleagues (p 593) found that the risk of both urinary and faecal incontinence was reduced at 12 months after delivery.
Linedrop
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of Clinical, Cultural and Psychosomatic Influences in the Teaching and Management of Diabetic Patients: A Study of Medically Indigent Negro Patients
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal