tbuckley/cabot-search huggingface dataset:
Preemptive Ganciclovir Therapy in Renal Transplantation
Authors: Michael Tamm
Journal: Annals of Internal Medicine (1996)

Letters1 April 1996Preemptive Ganciclovir Therapy in Renal TransplantationMichael Tamm, MD, Gieri Cathomas, MD, and Gilbert Thiel, MDMichael Tamm, MDUniversity Hospital; Basel, SwitzerlandSearch for more papers by this author, Gieri Cathomas, MDUniversity Hospital; Basel, SwitzerlandSearch for more papers by this author, and Gilbert Thiel, MDUniversity Hospital; Basel, SwitzerlandSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-7-199604010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In a recently published article on low-dose ganciclovir prophylaxis. Hibberd and colleagues [1] found a markedly reduced incidence of CMV disease in renal transplant recipients receiving antilymphocyte globulin. When antilymphocyte globulin was given to treat acute rejection, the incidence of CMV disease was as high as 64% in the 11 placebo recipients. Daily administration of ganciclovir (2.5 mg/kg of body weight) reduced the incidence of CMV disease to 22% (5 of 23 patients). At our institution, eight patients seropositive for CMV were treated with antilymphocyte globulin for steroid-resistant rejection and received higher doses of ganciclovir three times ...REFERENCE1. Hibberd PL, Tolkoff-Rubin NE, Conti D, Stuart F, Thistlethwaite JR, Neylon JF, et al. Preemptive ganciclovir therapy to prevent cytomegalovirus disease in cytomegalovirus antibody-positive renal transplant recipients. A randomized, controlled trial. Ann Intern Med. 1995; 123:18-26. Google Scholar Author, Article, and Disclosure InformationAuthors: Michael Tamm, MD; Gieri Cathomas, MD; Gilbert Thiel, MDAffiliations: University Hospital; Basel, Switzerland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCounterpoint: Prevention of Cytomegalovirus (CMV) Infection and CMV Disease in Recipients of Solid Organ Transplants: The Case for Prophylaxis 1 April 1996Volume 124, Issue 7 Page: 693 Keywords Antigens Body weight Creatinine Cytomegalovirus infection Globulins Liver Outpatient clinics Prophylaxis Renal diseases Renal transplantation ePublished: 15 August 2000 Issue Published: 1 April 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Treatment of HIV-associated Kaposi's sarcoma with aldoxorubicin.
Authors: Christopher Parsons, Shanta Chawla, Hillary Dinh, Scott Wieland, Daniel J. Levitt, Thomas Reske, Jim Outland, Virginia Garrison, Mary Meyaski-Schluter, Erin Meyaski, Bradley Spieler, Luis Del Valle, Jimena Trillo-Tinoco, Om Prakash, Adriana Zapata, Karlie Plaisance-Bonstaff, Katie Nguyen
Journal: Journal of Clinical Oncology (2015)

e21526 Background: Kaposi's sarcoma (KS) is an important cause of morbidity and mortality for HIV-infected patients. Treatment failure is associated with TIS (tumor extent, immune status, symptoms) scores (0 or 1 point for each), with reduced survival increasing with scores ≥ 1. Current treatment for KS involves either Doxil or paclitaxel, but treatment-related toxicites limit drug exposure. Aldoxorubicin (A) is a novel prodrug of doxorubicin that binds to the thiol group of the cysteine-34 of albumin and is released in the acidic environment associated with solid tumors. We report preliminary results for safety and efficacy in an initial cohort of patients with AIDS-associated KS. Methods: 9 patients were entered in the study; 4 had received prior Doxil chemotherapy for KS. Patients were administered 50, 100 or 150 mg/m2 Aldoxorubicin (37.5, 75 or 112 mg/m2doxorubicin equivalents), iv every 3 weeks. Tumor response and adverse events were recorded. Quantification of KS-associated human herpes virus 8 intracellular genome( KSHV) in biopsies was evaluated by confocal immunofluorescence microscopy. Uptake of doxorubicin into tumor tissue was assessed using a validated HPLC method. Results: 6/9 patients had a maximum TIS score of 3, 2 patients had a TIS score of 2 and 1 patient had a TIS score of 1 upon study entry. Only 1/9 patients had a grade 4 adverse event (neutropenia at 100 mg/m2A). 6/9 patients had either pulmonary KS (3 patients) or disease-associated adenopathy (3 patients); 4/6 patients (2 in each category responded to therapy. 1 patient (TIS 3) progressed after an initial response to therapy. 6/9 patients exhibited significant reductions in KSHV genome copies/cell . Doxorubicin could be detected in all tumor biopsies (11-35 ng/mg tissue). A subset of patients had improvements in quality of life, and all patients exhibited either improvement or stability in immuneologic and virologic HIV treatment parameters. Conclusions: In an initial cohort of patients with HIV-associated KS with advanced disease at enrollment, Aldoxorubicin was well-tolerated and was therapeutically active, including reductions in both pathological and radiographic disease. Aldoxorubicin may offer a safe and efficacious alternative to current therapy for KS. Clinical trial information: NCT02029430.
THE MICROBES OF THE STOMACH.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mitochondria Count May Help Evaluate Patients With Lymphocytic Leukemia
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nafcillin-associated hypokalemia
Authors: J. A. Mohr
Journal: JAMA (1979)

HYPOKALEMIA with or without metabolic alkalosis has been reported in patients receiving large doses of penicillin G potassium and carbenicillin disodium.<sup>1-4</sup>It has been suggested that the penicillins produce hypokalemia because of their action as a nonabsorbable anion.<sup>2,3</sup>However, Tattersall et al<sup>5</sup>reported that the antibiotic-associated hypokalemia is simply a redistribution of potassium within the body rather than a potassium loss. We describe a patient with staphylococcal septicemia treated with nafcillin sodium who experienced hypokalemia with excess urinary loss of potassium. <h3>Report of a Case</h3> A 23-year-old intravenous drug-addicted woman had a cesarean section for onset of premature labor and fetal distress. A nonviable infant was delivered. Two days after cesarean section, there was the onset of fever, tachycardia, and hypotension. She appeared acutely ill. Vital signs showed a blood pressure of 90/60 mm Hg; pulse rate was 140 beats per minute; temperature was 38.8 °C; respirations
Telstar Transmits Psoriasis Across the Atlantic
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Satoru Hagiwara, Naoshi Nishida, Masatoshi Kudo
Journal: Hepatology (2015)

Potential conflict of interest: Nothing to report. We read with great interest the correspondence from Sachar and Ma and appreciate their pointing out the important issues regarding cholestasis. As suggested, cholestasis could be one of the main causes of hepatic disorders in patients with erythropoietic protoporphyria.1 Indeed, the liver biopsy from the older brother also showed protoporphyrin (PP) deposition in the bile system. However, PP was predominantly observed in the hepatocytes with hepatocyte swelling and necrosis accompanied. Therefore, based on the histological findings and immunohistochemistry, we concluded that the liver damage should be mainly attributed to hepatocyte necrosis, primarily caused by PP deposition in the hepatocytes. Although an increase of the alkaline phosphatase level reflects cholestasis, elevated total bilirubin may reflect damage to hepatocytes as well as cholestasis. On the contrary, the liver biopsy from the younger brother, who had not suffered from liver dysfunction, showed more PP in the biliary system than the liver from the older brother but no PP in the hepatocytes. This evidence also supports the idea that PP deposition in hepatocytes is unique to liver damage, at least in the presented cases, and that the expression of ABCG2, a PP efflux transporter, should be involved in the pathogenesis. For PP detection in pathological specimens, we applied a polarized light microscope; a Maltese cross was confirmed during the observation, indicating that PP deposits were present in hepatocytes. The author also argued that down‐regulation of ABCG2 might be a consequence of liver injury because severe inflammation could affect the expression of proteins. We also addressed this issue; we analyzed the expression of other membrane transporters, ABCG6 and PEPT1. We did not find any differences in the expression of these transporters between the two brothers. Therefore, the difference in ABCG2 expression is specific among transporters; it is conceivable that the reduction of ABCG2 is not a result of liver injury. We already discussed this issue in a previous reply.3 Concerning age as a risk factor for liver damage, both brothers reported in our study were young, showing only a 2‐year difference in age. In addition, the older brother had developed hepatic disorders when he was 16 years old, suggesting that the difference in age should not primarily affect the pathogenesis of the cases.
285,000 Inactive Registered Nurses Could Turn the Tide
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
European Perspectives
Journal: Circulation (2011)

has worked to improve postcardiac arrest care.Professor Cariou says, "I have developed a hypothesis, with others, that postcardiac arrest acute care, and not just resuscitation itself, is important in protecting against further events, and that we are able to improve the prognosis of these patients by providing specific care.All my clinical research is in this area.The most important example is protection of the brain.I am interested in neurological outcomes.""It Is ot Easy to Offer This Treatment [Hypothermia], Because the Patients Are Comatose and in a Compromised Situation, But We Know That They eed to Be Cooled to Protect the Brain" Professor Cariou considers his most important work to be a collaboration with Christian
NEW LIFE MEMBERS
Journal: Annals of Internal Medicine (1955)

College News Notes1 March 1955NEW LIFE MEMBERSAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-3-735 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is a sincere pleasure for the College to announce that the following Fellows have become Life Members since the publication of the list in the February issue of this journal:Dr. Clifford J. Barborka, Chicago, Ill.Dr. Joseph Budnitz, Pittsfield, Mass.Dr. James F. Faulkner, Boston, Mass.Dr. Claude E. Forkner, Boston, Mass.Dr. Arthur Bliss Dayton, New Haven, Conn.Dr. Bernard H. Berman, Washington, Pa.Dr. Richard E. Gordon, New York, N. Y.Dr. Joseph W. Gardam, Newark, N. J.Dr. Marion E. Howard, New Haven, Conn.Dr. John R. Haserick, Cleveland, OhioGIFTS TO COLLEGE LIBRARY OF This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1955Volume 42, Issue 3Page: 735-762 ePublished: 1 December 2008 Issue Published: 1 March 1955 PDF downloadLoading ...
Accident proneness
Authors: M. Rodstein
Journal: JAMA (1974)

ACCIDENT proneness is a<i>personal idiosyncrasy</i>that predisposes certain individuals to a relatively high accident rate. The "diagnosis" is based on finding a high concentration of certain characteristics that have a high predictive value for the occurrence of accidents.<sup>1</sup>These indicators suggest considerable psychopathology: accidents among such individuals are not unplanned or unintentional on the subconscious level.<sup>1</sup> The following characteristics have been described as high in incidence among accident-prone individuals: youth (especially among males); early exposure to injury, violence, and domestic strife; severely authoritarian parents or parent figures; loss of parents; childhood nail biting, enuresis, or truancy; a tendency to lie and steal; and a history of many accidents in childhood. As adults, they tend to have childless marriages or small families, sexual conflicts, a high divorce rate, frequent changes in many types of jobs, adventurousness, irresponsibility, and aggressiveness. Under stress, they are often impulsive, make up their
Recognition of Illness Associated With the Intentional Release of a Biologic Agent
Journal: JAMA (2001)

On September 11, 2001, following the terrorist incidents in New York City and Washington, D.C., CDC recommended heightened surveillance for any unusual disease occurrence or increased numbers of illnesses that might be associated with the terrorist attacks. Subsequently, cases of anthrax in Florida and New York City have demonstrated the risks associated with intentional release of biologic agents. This report provides guidance for health-care providers and public health personnel about recognizing illnesses or patterns of illnessthat might be associated with intentional release of biologic agents.
LONDON LETTER.
Authors: None G. O. M.
Journal: JAMA (1885)

London, December, 1884. Dr. Arnold Royle, who was the private medical attendant of the late Duke of Albany, has been appointed "Gentleman Usher, Groom of the Privy Chamber, and Clerk of the Robes " to the Queen. The post is a sinecure and is worth about £ 280 a year. Dr. Royle has certainly earned the Queen's favor, for his late post was a most arduous and difficult one to fill. Three years ago, the Rev. Canon Erskine Clarke founded the Bolingbroke House Pay Hospital, which was intended for the reception of patients of the lower middle classes, and particularly for those who had fallen sick in lonely lodgings. They were to be received upon paying such a reasonable portion of their actual cost as the means of the patient allowed. It is obvious that by this means such an institution would be serving two very great objects, viz., the medical
Carcinogen Metabolism in Human Lung Tissues and the Effect of Tobacco Smoking: Results from a Case-Control Multicenter Study on Lung Cancer Patients
Authors: Helmut Bartsch, Stefano Petruzzelli, Silvio De Flora, Eino Hietanen, Anne-Marie Camus, Marcel Castegnaro, Kroum Alexandrov, Margarita Rojas, Rodolfo Saracci, Carlo Giuntini
Journal: Environmental Health Perspectives (1992)

Cigarette smoking is the strongest risk factor for lung cancer, but genetically determined variations in the activities of pulmonary enzyme that metabolize tobacco-derived carcinogens may affect individual risk.To investigate whether these enzymes (e.g., CYPIA-related) can serve as markers for carcinogen-DNA damage, lung tissue specimens were taken during surgery from middle-aged men with either lung cancer or nonneoplastic lung disease.Phase I [aryl hydrocarbon hydroxylase (AHH), ethoxycoumarin O-deethylase (ECOD)] and ph;e-Ceipoxide hydrolase, UDP-glucuronosyltransferase, glutathione S-transferase) enzyme activities, glugtathione and malondialdehyde contents were determined in lung parenchyma and/or bronchial tissues; -some samples were also analyzed for DNA adducts, using 32P-postlabeling.The data were then analyzed for the following: a) differences in metabolic profiles between bronchial and parenchymal lung tissue; b) the effect of recent exposure to tobacco smoke on enzyme inducibility and benzo[a]pyrene metabo- lism; c) differences in enzyme inducibility between lung cancer and non-lung cancer patients; d) the effect of smoking on metabolism of mutagens in vitro; e) pulmonary DNA adduct levels and AHH activity in lung parenchyma of smokers and ex-smokers; I) lipid peroxidation products in lung tissue from lung cancer and non-lung cancer patients, as related to smoking habits and degree of airway obstruction; and g) prognostic value of AHH pulmonary activity in lung cancer patients.The results demonstrate a pronounced effect of tobacco smoke on pulmonary metabolism of xenobiotics and prooxidant state and suggest the existence of a metabolic phenotype at higher risk for tobacco-associated lung cancer.
A STATUTORY INCONSISTENCY.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LOCALIZATION OF MUSICAL CENTERS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal