tbuckley/cabot-search huggingface dataset:
Abstract 17210: Cardiorespiratory Fitness and Non Fatal Cardiovascular Events
Authors: Hassan Khan, Rainer Rauramaa, Sudhir Kurl, Kai Savonen, Jari A Laukkanen
Journal: Circulation (2015)

Introduction: To examine the relationship between cardiorespiratory fitness (CRF) and risk of non-fatal cardiovascular events. Methods: Cardiorespiratory fitness, as measured by maximal oxygen uptake (VO2max), was assessed at baseline in a prospective cohort of 2,089 men aged 42-61 years from the Kuopio Ischaemic Heart Disease Study (KIHD). Results: During a mean follow-up of 19.1 years (SD 8.4), 522 non-fatal acute myocardial infarction (MI) events, 198 acute all cause non-fatal stroke events and 221 non-fatal incident heart failure (HF) events were recorded. The hazard ratio (HR) per 1 MET increase in CRF was 0.93(95% CI: 0.88-0.97) for non-fatal MI, 0.94(95% CI: 0.87-1.01) for non-fatal stroke and 0.84(95% CI: 0.78-0.91) for non-fatal HF events after adjustment for established cardiovascular risk factors (age, systolic blood pressure, body mass index, history of cardiovascular disease, diabetes, smoking, alcohol use, serum creatinine, low density lipoprotein levels, physical activity and socioeconomic status). Further adjustment for additional risk factors did not substantially attenuate these associations. In a comparison of extreme quartiles of CRF levels, the corresponding adjusted HRs were 0.74 (95% CI: 0.55-0.99) for non-fatal MI, 0.91(95% CI: 0.58-1.44) non-fatal stroke and 0.49(95% CI: 0.30-0.80) for non-fatal HF respectively, Figures 1&amp; 2. Conclusions: In this Finnish population, there is a strong, inverse, and independent association between CRF and non-fatal MI and HF risk, but not for acute non-fatal stroke events. The protective effect of CRF on non-fatal cardiovascular events needs further investigation in larger studies.
Brachial plexus neuropathy. Association with desensitizing antiallergy injections
Authors: E. R. Wolpow
Journal: JAMA (1975)

Two patients had acute, self-limiting, unilateral brachial plexus neuropathy in association with desensitizing subcutaneous injections of extracts of dusts and molds. Diminution of pain and return of function of the affected limb followed a short course of prednisone therapy, although a beneficial effect of the steroid cannot be considered proved. There is a large variety of antigenic substances already known to produce neuropathy following intramuscular injection; desensitizing antiallergy injections should be added to this list. (<i>JAMA</i>234:620-621, 1975)
AB0210 Studying of thew efficiency of the synvisk in osteoparthrosis
Authors: LD Groppa, M Moschneaga
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> At present for improvement of life quality in patients with osteoarthrosis is necessary to solve some problems: precluding of development of degenerative process in cartilage of affected joint, relieving of pain and improving of the function of the joint. <h3>Objectives</h3> <h3>Methods</h3> For these aims we studied the efficiency of the chondroprotective drug Synvisk by Boehringer Ingelheim in 25 patients with arthrosis of the knee in medium age of 61.2 ± 1.7 years, 16 women and 8 men, with duration of the disease 5.8 ± 0.9 years. Conform X-ray data the distribution of the patients by stages of the disease was as follow: I grade ? 20%, II grade ? 64%, and III grade ? 16%. In experimental group the drug was administered intraarticular by blind method in dose of 2.0 ml one time in a week, 3 injections for the course, which were repeated after 6 and 12 months. The control group was matched by gender, duration of disease and X-ray date; in this group was administrated placebo conform same scheme. Evaluation of the effectiveness and tolerability of compared drugs was carried out in evolution of clinical (pain, functional index by Lesquesne, volume of movement on affected joints), X-ray parameters and functional methods (ultrasonography, scintigraphy with Te99m. <h3>Results</h3> In the basic group were mentioned decreasing of the pain intensity and improvement of the joint functions just after single injection in one third of the patients, while in control groups similar cases were absent. After 3 courses of the treatment in the basic group the effects were obtained in 86.7% of the patients, including 33.3% very good effect, in 53.4% moderate effect and only in 13.3% the effects were absent. In control group there were no effects in 80% of the patients, and in 20% of the patients there were mentioned moderate effects; good effects were are not observed. <h3>Conclusion</h3> Thus, presented results suggests that administration of Synvisk lead to significant improvement of the life quality in the patients with arthrosis of the knee.
Pressure Ulcers
Authors: David M. Smith
Journal: Annals of Internal Medicine (1996)

Letters1 September 1996Pressure UlcersDavid M. Smith, MDDavid M. Smith, MDVeterans Affairs Medical Center, Indianapolis, IN 46202Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I appreciate the comments of Drs. Francis and Pica and of Dr. Landi and colleagues. Both letters stress the importance of multidisciplinary involvement and of systematic assessment in addressing the problem of pressure ulcers in the nursing home. As stated in my review, before-and-after studies have shown that involvement of multidisciplinary teams can reduce the prevalence and incidence of this condition [1, 2]. Landi and colleagues appropriately add an important dimension, the use of the Minimum Data Set for nursing home resident assessment [3]. The Minimum Data Set provides a systematic and comprehensive resident assessment instrument and has ...References1. Dimant J, Francis ME. Pressure sore prevention and management. J Gerontol Nurs. 1988; 14:18-25. Google Scholar2. Ameis A, Chiarcossi A, Jimenez J. Management of pressure sores. Comparative study in medical and surgical patients. Postgrad Med. 1980; 67:177-84. Google Scholar3. Morris JN, Hawes C, Fries BE, Phillips CD, Mor V, Katz S, et al. Designing the national resident assessment instrument for nursing homes. Gerontologist. 1990; 30:293-307. Google Scholar4. Brandeis GH, Berlowitz DR, Hossain M, Morris JN. Pressure ulcers: the Minimum Data Set and the resident assessment protocol. Adv Wound Care. 1995; 8:18-25. Google Scholar Author, Article, and Disclosure InformationAuthors: David M. Smith, MDAffiliations: Veterans Affairs Medical Center, Indianapolis, IN 46202 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1996Volume 125, Issue 5Page: 422KeywordsDatabasesNursing homesPressure ulcers ePublished: 15 August 2000 Issue Published: 1 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
English-Spanish Medical Dictionary. (Diccionario Médico Inglés-Español).
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacteriology of chronic otitis media
Authors: I. Brook
Journal: JAMA (1979)

Tympanocentesis was performed in 50 patients with chronic otitis media; pus was cultured aerobically and anaerobically. Only aerobes were isolated from 21 patients (42%), three patients had only anaerobes (<i>Peptococcus</i>sp), and 25 patients (50%) had both aerobes and anaerobes. Only one specimen had no growth. There were 68 aerobic isolates.<i>Pseudomonas aeruginosa</i>was recovered in 36 patients (72%); other aerobes commonly recovered included<i>Proteus</i>sp and<i>Staphylococcus aureus</i>. There were 48 anaerobes isolated. Anaerobic Gram-positive cocci were isolated in 24 instances (21<i>Peptococcus</i>sp and three<i>Peptostreptococcus</i>sp). Sixteen<i>Bacteroides</i>sp were recovered, including seven<i>B fragilis</i>group and six<i>B melaninogenicus</i>. (<i>JAMA</i>241:487-488, 1979)
Genetic Anomalies in Mammalian Germ Cells and Their Significance for Human Reproductive and Developmental Risk
Authors: Vicki L. Dellarco
Journal: Environmental Health Perspectives (1993)

The induction of heritable mutations in germ cells represents a potential health concern.This paper highlights data from mouse germ-cell mutagenesis studies that have implications in the assessment of reproductive and developmental risks.The paper discusses the developmental and reproductive consequences of induced chromosomal damage (structural rearrangements and numerical anomalies) and describes environmental agents that have been shown to produce such anomalies.Additionally, factors that influence the yield of genetic damage are addressed.Studies showing that the various germ-cell stages vary in their susceptibility to the induction of genetic damage are summarized.Of the chemicals evaluated in the male mouse, most appear to have their predominant or strongest effect on post-stem-cell stages.The differences between males and females in the susceptibility to mutagens is examined.Recent studies have shown that the female may be uniquely sensitive to certain mutagens.Finally, an important aspect of mutagenic risk is not only effects induced in developing germ cells but also the effects of environimental agents during the period from fertilization through the zygote and the two-cell embryo.Recent work in the mouse has demonstrated that exposure during these early developmental stages leads to high frequencies of external and visceral fetal malformations, as well as mid-to-late gestational death.
Determination of Platinum, Palladium, and Lead in Biological Samples by Atomic Absorption Spectrophotometry
Authors: John B. Tillery, Donald E. Johnson
Journal: Environmental Health Perspectives (1975)

A flameless atomic absorption method for the coextraction of platinum and palladium from biological and environmental samples by high molecular weight amine (HMWA) is given. Also, methods for lead determination in biological samples by use of extraction flameless analysis and direct aspiration-flame analysis are reported. A study of lead contamination of Vacutainer tubes is given.
Studies question right heart catheterization
Authors: P. Cotton
Journal: JAMA (1994)

LIKE MANY technologies, right heart catheterization became established in clinical practice without ever being studied in randomized controlled trials. Physicians often consider data provided by the procedure, in which a catheter is threaded into the heart to provide continuous readings of central venous blood pressure and estimate intravascular volume, to be essential in making treatment decisions. An attempt to conduct a randomized controlled trial in Canada failed because physicians would not submit enough patients for randomization, believing that they already knew when and how to use the procedure. Yet there is wide variation in when and how it is used. Right heart catheterization is performed on more than 1 million patients in the United States each year, at an average cost of $2000 each. Now, however, two studies that controlled for severity of illness are raising questions about possible benefits of the procedure. One study could find no overall benefit
Abstract A54: Intravital microscopy of prostate cancer lesions in bone: Kinetics of osteolysis and therapy response
Authors: Eleonora Dondossola, Stephanie Alexander, Steve Alexander, Boris Holzapfel, Christopher Logothetis, Dietmar Hutmacher, Peter Friedl
Journal: Cancer Research (2016)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR04) of the Conference Proceedings. Citation Format: Eleonora Dondossola, Stephanie Alexander, Steve Alexander, Boris Holzapfel, Christopher Logothetis, Dietmar Hutmacher, Peter Friedl. Intravital microscopy of prostate cancer lesions in bone: Kinetics of osteolysis and therapy response. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr A54.
Repetitorium der Chemie.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P156: Dietary Patterns and Incident Hypertension in Mexican Women
Authors: Adriana Monge, Ruy Lopez-Ridaura, Jose J Gongora, Martin Lajous
Journal: Circulation (2016)

Introduction: A dietary pattern characterized by a combination of a traditional maize-based diet and street-food with sodas, showcasing the nutritional transition in Mexico, may be differentially associated with hypertension. Hypothesis: Dietary patterns reflecting overall diet are associated with incident hypertension. Methods: We investigated the relation between dietary patterns and the incidence of self-reported hypertension in 62,440 women from the Mexican Teachers’ Cohort (MTC) who were free of hypertension at baseline in 2008 when diet was assessed using a food frequency questionnaire (FFQ). Between baseline and 2011 we identified 2874 incident cases of hypertension. We identified 3 major energy-adjusted dietary factors using factor analysis in a self-reported FFQ. The first factor loaded heavily on fruits and vegetables; the second factor on processed meats, fast foods, and red meat; and the third factor on corn tortillas, chili, sodas, legumes, and street-food. Factors were named Fruits &amp; Vegetables, Western, and Modern Mexican, respectively. Dietary patterns were categorized into quintiles and logistic regression models were fit. Age and multivariable odds ratios with the lowest category as a reference were estimated; we adjusted for age, socioeconomic status, insurance, education, region, menopause, diabetes, hypercholesterolemia, smoking, activity, and energy intake. Results: The multivariable-adjusted odds of hypertension in the highest quintile of the Fruit &amp; Vegetable pattern were 18% lower than the odds for individuals in the lowest quintile (95%CI=0.74-0.91;P-trend&lt;0.0001). Comparing extreme quintiles, the Western pattern was associated with a 17% increase in hypertension (95%CI=1.05-1.31;P-trend=0.001); and the Modern Mexican pattern with a 21% increase (95%CI=1.08-1.34;P-trend&lt;0.0001). Conclusion: The dietary patterns derived from the MTC’s FFQ are associated with hypertension. Exploring them may generate new hypotheses on dietary factors associated with hypertension.
Abstract 238: Therapeutic activity of the non-internalizing antibody drug conjugate 1959-sss/DM3 targeting galectin3-binding protein in human neuroblastoma
Authors: Emily Capone, Sara Ponziani, Francesco Giansanti, Roberta Gentile, Giulia Di Vittorio, Vincenzo De Laurenzi, Michele Sallese, Sandra Bibbò, Arturo Sala, Rodolfo Ippoliti, Jean Frederic Sauniere, Stefano Iacobelli, Gianluca Sala
Journal: Cancer Research (2019)

Abstract Neuroblastoma is a solid tumour affecting the peripheral nervous system accounting for ∼13% of all pediatric cancer mortality. Despite immunotherapy with the GD2 antibody has improved the clinical outcome of a fraction of patients with metastatic neuroblastoma, the majority of patients with relapsing, high risk disease cannot be successfully treated. Recently, it has been shown that non-internalizing, linker-less antibody drug conjugates (ADCs) targeting the tumor extracellular environment can exert a potent therapeutic activity against different tumors. We identified LGALS3BP (aka Mac-2 BP or 90K) as an important target for non-internalizing ADC development, as the protein is largely secreted by the majority of human tumors, while being virtually undetectable in normal adult tissues. In this study, we show that a variant of the humanized 1959 antibody, targeting human LGALS3BP, coupled to the maytansinoid drugs DM3 by means of disulfide linker, bound human neuroblastoma cell lines harboring or not N-myc amplification, although with different affinity. Importantly, normal human fibroblasts were not decorated by the antibody. The ADC potently inhibited metastatic lesions in the liver and lungs of NSG mice injected intravenously with the neuroblastoma cell line SKNAS. Our findings offer a preclinical proof-of-concept for the development of a non-internalizing ADC endowed with potent therapeutic activity for neuroblastoma treatment through an innovative mechanism of action. Citation Format: Emily Capone, Sara Ponziani, Francesco Giansanti, Roberta Gentile, Giulia Di Vittorio, Vincenzo De Laurenzi, Michele Sallese, Sandra Bibbò, Arturo Sala, Rodolfo Ippoliti, Jean Frederic Sauniere, Stefano Iacobelli, Gianluca Sala. Therapeutic activity of the non-internalizing antibody drug conjugate 1959-sss/DM3 targeting galectin3-binding protein in human neuroblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 238.
Abstract MP55: Systemic Arterial Compliance Predicts All-cause Mortality and Cardiovascular Mortality: The Rancho Bernardo Study
Authors: Bledar Daka, Robert D Langer, Matthew Allison, Ulf Lindblad, Vani Dandolu, Elizabeth Barrett-Connor
Journal: Circulation (2016)

Objective: To investigate the association between peripherally measured arterial compliance and cardiovascular and total mortality in an elderly cohort. Background: There is limited evidence that systemic indices of elasticity and stiffness in the carotid and femoral arteries can predict incident cardiovascular disease (CVD) events. Little is known about the associations between systemic arterial compliance and CVD events. Methods: Between 1997 and 1999, 849 community dwelling participants in the Rancho Bernardo Study (mean age 74, 39% male, 4.2% with type 2 diabetes) underwent noninvasive pulse wave measurements. Systemic and brachial artery compliance were estimated using the PulseMetric device applying an algorithm previously validated by angiography. Data on cardiovascular risk factors and fasting blood samples were obtained at the same visit as the compliance measurements, as well as at a follow-up visit conducted within one year. CVD and overall mortality were recorded through January 2013. Kaplan-Meier survival curves for quartiles of systemic and brachial artery compliance were constructed. Cox proportional hazards models were used to examine the associations of systemic and brachial artery compliance with all-cause and CVD mortality. Multivariable models were used to assess interactions and to estimate the role of potential confounders. Stratified models were constructed when interactions of p&lt;0.15 were found. Results: During a mean follow-up of 10 years (SD=3.9), 324 deaths occurred, 114 of which were attributed to CVD. Kaplan-Meier curves suggested an increasing probability for survival with increasing quartiles of arterial systemic compliance (p &lt; 0.001). In the fully adjusted Cox proportional hazard model, a 1-SD increment in systemic compliance was associated with a 39% lower risk of mortality (HR = 0.61, 95% CI: 0.47-0.79) and a 37% lower risk for CVD mortality (HR = 0.63, 95% CI 0.41-0.96). A significant interaction by sex was found (p=0.01). Specifically, among women, the association between systemic arterial compliance and mortality was stronger in the fully adjusted model (HR = 0.59, 95% CI 0.42-0.83) than in men (HR = 0.70, 95% CI 0.50-0.96). Similar sex-specific associations were found for CVD mortality, but those were not statistically significant (HR in women = 0.60, 95% CI 0.38-1.08; HR in men = 0.64, 95% CI 0.35-1.17). Brachial artery compliance was not significantly associated with the considered events (all-cause mortality: HR 0.86, CI 0.66-1.14; CVD mortality: HR 0.99, CI 0.59-1.63). Conclusions: In an elderly cohort, systemic arterial compliance, but not brachial artery compliance, was significantly associated with total and CVD mortality, and the relationships were stronger in women. Non-invasive measurement of systemic compliance may be useful in predicting mortality risk in older, community-dwelling adults.