tbuckley/cabot-search huggingface dataset:
PAROXYSMAL HYPERTENSION
Authors: A Belkin, D Macqueen, John Duffin
Journal: Annals of Internal Medicine (1933)

A.S., male, aged 59, was seen in October, 1946, complaining of headache, dizziness, and a rather vague epigastric distress after eating, which was not relieved by meals.Physical examination re- vealed a blood pressure of 170/100.He was found to have an opaque right antrum, occa- sional glycosuria and an abnormal glucose toler- ance curve.Fasting 144 mgm., 1/2 hour 240 mgm., 1 hour 305 mgm., 2 hours 114 mgm., 3 hours 50 mgm.%.The glycosuria was controlled by diet.The antrum was irrigated on a number of occasions and pus drained.He was discharged slightly improved, although he still complained of fre- quent headaches.There was a note in his history that he was a difficult patient.The patient was next seen in March, 1947.He now complained of severe "dizzy spells".They had started a few months before, but were now appearing so often that he was afraid to go out on the street.These attacks always fol- lowed a definite pattern.They were of sudden onset, with objects rotating vertically and counter-clockwise, and often would cause him to fall down.He 'was also cwmplaining of a con- tinuous ringing of the right ear and a rather rapidly progressing deafness of the same ear.The vague epigastric distress continued.He was in the hospital for about three months until his rightsided deafness became complete.During this time the Meniere's syndrome largely disappeared.His blood pressure on two occa- sions was 150/85 and 140/80.The electrocardio- gram was normal.Occasional glycosuria was still present.
Activated charcoal in tricyclic drug overdoses.
Journal: BMJ (1972)

non-immune rosette formation are the facts that a relatively large proportion of lymphocytes of unimmuniz-d animais participate in the reaction, and that thymocytes are more active than non-thymic lymphocytes.The proportion of human lymphocytes which adhere to sheep red cells is often relatively large in non-immunized human subjects, and human fetal thymocytes are more active than peripheral lymphocytes.9The adherence of non-immunized human lymphocytes to sheep red cells is therefore likely to occur through non-immune rather than immune mechanisms.The adherence probably occurs through fortuitous cross- reactivity of sheep red cells with human lymphocyte surface receptors concerned with an autologous non-immune adherence.-Iam, etc.,
THE IMMIGRATION SERVICE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General hepatology update
Journal: Hepatology (2003)

The aim of the work described here was to compare the accuracy of conventional handheld ultrasound (HHUS) with that of an automated breast volume scanner (ABVS) in 3-D assessment of pre-operative invasive ductal carcinomas. HHUS and ABVS were used in 51 patients to obtain the largest tumor diameter, tumor volume and tumor surface area. The volumetric measurement was also obtained from ABVS data with medical software. With tumor size and volume on pathology as the gold standard, Bland–Altman analysis was used to compare variability. Correlation coefficients and receiver operating characteristic curves were established for all measurements for T2 classification. The correlation coefficients of all ABVS measurements were stronger than those of HHUS measurements, with the ABVS volumetric measurement significantly different with a higher accuracy of 88.24% (45/51) and predicting T-classification with higher area under the receiver operating characteristic curves (0.936). Therefore, 3-D measurements provide stronger correlations with pathology in tumor size measurement. However, more clinical trials are needed to confirm our findings.
IgA class antibodies to hepatitis delta virus antigen in acute and chronic hepatitis delta virus infections
Authors: I McFarlane
Journal: Hepatology (1991)

Sera from 31 patients with chronic hepatitis delta virus infection and 18 patients with acute hepatitis delta virus infection were examined for IgA class antibodies to this virus using a newly developed enzyme immunoassay. IgA antibody to hepatitis D virus was detected in 21 (67.7%) of 31 patients with chronic delta viral hepatitis, but in only 1 (5.6%) of the 18 patients with acute infection (p < 0.0005). Of the 21 patients with chronic delta hepatitis with IgA antibody to hepatitis D virus, 19 (90.5%) had moderate-to-severe activity on liver biopsy: 18 of the 21 had histological features of chronic active hepatitis and three had chronic lobular hepatitis. In all, 23 patients with chronic delta hepatitis had moderate-to-severe activity, and 19 (82.6%) had IgA antibody to hepatitis D virus. No statistically significant correlations were found between IgA antibody to hepatitis D virus and biochemical markers of liver injury (p > 0.4), or the presence of hepatitis delta virus antigen in liver biopsies (p > 0.2), in the patients with chronic delta hepatitis. The finding that IgA antibody to hepatitis D virus was almost exclusively associated with chronic hepatitis delta virus infection and correlated independently with moderate-to-severe histological activity (with a specificity of 90.5% and a sensitivity of 82.6%) suggests that this antibody might be a useful serological marker of underlying liver damage in chronic delta hepatitis. (HEPATOLOGY 1991;14:980–984.)
J Pharmacol &amp;amp; Exper Therapeutics, Baltimore
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Catheter-induced lesions of the right side of the heart. A one-year prospective study of 141 autopsies
Authors: B. S. Ducatman
Journal: JAMA (1985)

We examined prospectively for one year the hearts from 141 consecutive autopsy cases in which a central catheter was present at the time of death. Three deaths were attributable to catheter use, two to perforation. Furthermore, mural thrombi were present in 33 (33%) of 99 patients with pulmonary arterial catheters and in 12 (29%) of 42 patients with central venous catheters. The incidence of pulmonary emboli or bacteremia was no greater in patients with thrombi than in those without. The use of central catheters may thus be complicated by perforation or the development of mural thrombi. Although the thrombi may embolize or may become infected, the incidence and clinical significance appear to be low. The incidence of catheter-related deaths in our autopsy population does not necessarily reflect the incidence in a population of living patients. (<i>JAMA</i>1985;253:791-795)
Die gynäkologischen Operationen und ihre topographisch-anatomischen Grundlagen
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitric oxide
Authors: Sheryl A. Falkos, Thomas A. Nakagawa, Anne P. M. C. De Jaegere, Frans I. M. Jacobs, Nico G. C. Laheij, John N. van den Anker, Jörg Dötsch, Süha Demirakça, Rudolf Hamm, Jürgen Bauer, Peter Gonne Kühl, Jacques Cotting, N. Sekarski, P. Stucki, P. Terrier, M. Payot, M. Hurni, R. Laurini, Ira M. Cheifetz, Damian M. Craig, Frank H. Kern, Peter K. Smith, Jon N. Meliones, V. Varnholt, P. Lasch, W. Müller, G. Suske, J. Sartoris, W. Kachel, Gerfried Zobel, Bernd Urlesberger, Drago Dacar, Siegfried Rödl, Fritz Reiterer, Ingeborg Friehs
Journal: Intensive Care Medicine (1996)
An Appraisal of the Criteria of Cerebral Death
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Perinatal and Multigenerational Effect of Carcinogens: Possible Contribution to Determination of Cancer Susceptibility
Authors: Hiroshi Yamasaki, Alexandre Loktionov, Lorenzo Tomatis
Journal: Environmental Health Perspectives (1992)

Perinatal exposure to carcinogens may contribute to the determination of susceptibility to cancer in two situations: a) exposure in utero of embryonal or fetal somatic cells to carcinogens, and b) prezygotic exposure of the germ cells of one or both parents to carcinogens. Epidemiological as well as experimental studies demonstrate that exposure to carcinogens in utero increases the occurrence of cancer postnatally. Studies with experimental animals suggest that prezygotic exposure of germ cells to carcinogens can result in an increased incidence of cancer not only in immediate but also in subsequent generations. Although several studies suggest a transgeneration effect of carcinogens in human populations, the evidence cannot yet be considered conclusive. In particular, while some hypotheses can be advanced, the mechanism(s) by which increased susceptibility or predisposition to cancer may be transmitted via the germ cells has not yet been clarified. In conjunction with exposure both in utero and prezygotically, it is important to consider postnatal exposure to possible tumor-promoting agents. Results from experimental animals suggest that oncogenes can be activated transplacentally, and human studies indicate that tumor-suppressor gene inactivation may be involved in the transgenerational effect of carcinogens.
Abstract 4565: The functional role of atypical chemokine receptor 1 in immune cell regulation of breast cancer
Authors: Brittany D. Jenkins, Rachel Martini, Kevin Gardner, Michele Monteil, Dorrah Deeb, Lisa Newman, Melissa Davis
Journal: Cancer Research (2019)

Abstract Breast cancer (BC) is a heterogeneous disease that leads to varied molecular subtypes and distinct clinical outcomes. Tumor heterogeneity, which is in part influenced by genetic ancestry, contributes to racial disparities in BC. This disparity has persisted for over 30 years, despite improvements in detection, screening, and treatment methods. When investigating race-specific differences in the breast tumor microenvironment (TME), we believe that chemokine receptors, such as atypical chemokine receptor 1 (ACKR1/DARC), play an integral role in regulating chemokine and immune cell migration in circulation and the TME, ultimately influencing tumor progression. ACKR1/DARC specifically plays a role in ancestry-related differences in BC due to an African-specific ancestral allele (“Duffy-null” mutation) that is fixed in Sub-Saharan African populations, and present in 60-70% of African-Americans. Those that harbor the mutation do not express ACKR1/DARC on erythrocytes, ultimately affecting immune cell migration in these populations only. To better understand the effects of this variant in circulation and the TME, we performed immunohistochemistry (IHC) on breast tumors from a cohort of patients with matched blood samples. From our IHC analysis, we quantified levels of ACKR1/DARC, in addition to levels of target pro-inflammatory chemokines, and distinct immune populations of T-cells and macrophages. In addition, individuals were genotyped to determine Duffy-null status, and a correlative Luminex multiplex assay was performed on patient plasma to determine concentrations of pro-inflammatory chemokines in circulation. We determined that those with low expression of ACKR1/DARC in tumors exhibited a unique signature of immune cell infiltrates that would encourage a more aggressive TME. In addition, we observed variable levels of circulating chemokines, where those with the Duffy-null mutation exhibited significantly decreased levels of CCL2. Overall, our analyses support the hypothesis that tumor-specific DARC/ACKR1 plays a vital role in immune cell regulation in women with BC. Citation Format: Brittany D. Jenkins, Rachel Martini, Kevin Gardner, Michele Monteil, Dorrah Deeb, Lisa Newman, Melissa Davis. The functional role of atypical chemokine receptor 1 in immune cell regulation of breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4565.
The Wedding
Authors: M. Therese Southgate
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Authors: Mr White
Journal: BMJ (1898)

Iextreme deformity of the pelvis abdominal hysterectomy was necessary.n1x897 the patient returned with a ventral hernia, which was successfully operated upon.She is now in excellenit health earning lher living.I should be extremely obliged if any memlers of the medical pro- fession who have had a patient operated upon at the New Hospital for Women under their care would be good enough to let miie know the sub- sequent history of the case, as there are over I0o patielts whose after- histories I have not been able to trace.It is possible that amongst this number other cases of intestinal obstruction or venitral hernia have oceurred, but so far as we know patients who have had subsequent trouble have returned to the hospital for -further treatment. ANSWERS.PERPLEXED.-There is no rule about the matter, which iimust be decided by ever-y man for himself.I. M. S.-Dr.Reid's portable oplhthalmo:neter can be procured from the
Bioassay of Complex Mixtures Derived from Fossil Fuels
Authors: Eula Bingham, William Barkley
Journal: Environmental Health Perspectives (1979)

The conversion or processing of shale, coal, or petroleum involves elevated temperatures and altered pressures, and under these conditions polynuclear aromatic hydrocarbons are likely to form. Certain compounds of this type exhibit carcinogenic activity for a variety of organ sites in experimental animals and epidemiological evidence strongly implicates their role as carcinogens in man. It is then not unexpected that many liquid fractions derived from shale and coal are carcinogenic when subjected to bioassay. Benzo(a)pyrene, [B(a)P], is frequently considered to be an indicator substance. It is clear that when a small quantity of B(a)P is present in a fraction, the fraction will exhibit carcinogenic activity in a bioassay (mouse skin). However, it does not follow that the lack of detectable B(a)P insures that the fraction will be noncarcinogenic. Several fractions have been analyzed for their content of B(a)P and then subjected to bioassay. A method for testing complex mixtures for their carcinogenic potential is described. The carcinogenic potency of these fractions are compared to petroleum fractions.
Spontaneous rupture of the stomach
Authors: A. M. Schwartz
Journal: JAMA (1966)

SPONTANEOUS rupture of the stomach is a catastrophic entity. In none of the 45 cases hitherto reported was the diagnosis made prior to surgery or autopsy.<sup>1,2</sup>Since this condition was not thought of as a diagnostic possibility, apparently few physicians are aware of it. <h3>Report of a Case</h3> A 65-year-old white woman was admitted to Montefiore Hospital complaining of generalized abdominal pain. Two hours prior to admission, while eating a large dinner, she noted abdominal discomfort. She took several effervescent antacid tablets dissolved in water, her abdomen became acutely distended, and she vomited repeatedly. She was known to have diverticulosis and had been on a self-imposed, low-calorie, low-residue diet for several weeks. Upon admission she was in acute distress with cold moist skin and a cyanotic appearance. The abdomen was distended, tympanitic, and rigid. Her blood pressure was 80/0 mm Hg; pulse rate, 130 beats per minute; and central-venous
ACC/AHA/ESC Guidelines for the Management of Patients With Atrial Fibrillation: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation) <i>Developed in Collaboration With the North American Society of Pacing and Electrophysiology</i>
Authors: Valentin Fuster, Lars E. Rydén, Richard W. Asinger, David S. Cannom, Harry J. Crijns, Robert L. Frye, Jonathan L. Halperin, G. Neal Kay, Werner W. Klein, Samuel Lévy, Robert L. McNamara, Eric N. Prystowsky, L. Samuel Wann, D. George Wyse, Raymond J. Gibbons, Elliott M. Antman, Joseph S. Alpert, David P. Faxon, Valentin Fuster, Gabriel Gregoratos, Loren F. Hiratzka, Alice K. Jacobs, Richard O. Russell, Sidney C. Smith, Werner W. Klein, Angeles Alonso-Garcia, Carina Blomström-Lundqvist, Guy de Backer, Marcus Flather, Jaromir Hradec, Ali Oto, Alexander Parkhomenko, Sigmund Silber, Adam Torbicki
Journal: Circulation (2001)

IntroductionAtrial fibrillation (AF), the most common sustained cardiac rhythm disturbance, is increasing in prevalence as the popu-lation ages.Although it is often associated with heart disease, AF occurs in many patients with no detectable disease.Hemodynamic impairment and thromboembolic events result This document was
Hepatic cyst computed tomography of human fascioliasis obstructive phase . Hospital Library, First Affiliated Hospital, Jiangxi Medical College, Nanchang, 33006, China
Journal: Hepatology (1995)

Hyperglycemia-induced oxidative stress has been suggested as a mechanism underlying diabetic complications. Oxidative stress triggers cell death in various cell types, including glomerular mesangial cells which play important roles in diabetic nephropathy. In the present study, we investigated the potential cytoprotective effect of erigeroflavanone, a novel flavanone derivative from the flowers of Erigeron annuus, in cultured mouse mesangial cells using hydrogen peroxide (H2O2) as an oxidative stress inducer. Our data show that hydrogen peroxide induced a decrease in cell viability that was attenuated by erigeroflavanone. Hydrogen peroxide treatment increased formation of dichlorofluorescein (DCF)-sensitive intracellular reactive oxygen species (ROS). This enhanced ROS formation was significantly reduced by pretreatment with erigeroflavanone in a dose-dependent manner. Hydrogen peroxide treatment also induced phosphorylation of the mitogen-activated protein kinases (MAPKs), c-Jun terminal kinase (JNK), extracellular-regulated kinase (ERK) and p38, and activated caspase-3. Pretreatment with erigeroflavanone inhibited hydrogen peroxide-induced activation of MAPKs and caspase-3. From these data we conclude that erigeroflavanone provides a protective effect against oxidative stress-induced cell death in mesangial cells that is associated with its antioxidant action and inhibition of MAPKs and caspase-3. These results suggest that erigeroflavanone has potential as a therapeutic agent in the treatment of renal diabetic complications.