tbuckley/cabot-search huggingface dataset:
The Physiologic and Clinical Significance of Plasma Proteins and Protein Metabolites
Authors: Jack Metcoff, Fredrick J. Stare
Journal: New England Journal of Medicine (1947)

Circulating Protein MetabolitesThe circulating plasma proteins represent one phase in the dynamic equilibrium existing between plasma and tissue proteins. Another clinically important phase of protein metabolism in health and disease is associated with the circulating protein catabolites. These nonprotein nitrogenous substances are the resultants of intermediary metabolism of ingested and tissue proteins. The nonprotein nitrogen of the blood — that portion not precipitated by the usual protein precipitants —is a heterogenous mixture of urea, uric acid, amino acids, creatine, creatinine and a fraction designated as "undetermined nitrogen" that appears to contain polypeptides, various amino acids, adenylicnucleotide and other components. . . .
POSTURE AND BLOOD PRESSURE
Authors: G. R.
Journal: Annals of Internal Medicine (1935)

Editorial1 November 1935POSTURE AND BLOOD PRESSUREG. R.G. R.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-5-638 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe physiologic responses of the circulatory system to changes in posture were first studied in animals by Hill and Barnard1in 1897. They found, by placing a dog in the vertical position, feet down, and cutting the cervical portion of the spinal cord, that the pressure in the aorta dropped to zero and most of the blood was collected in the splanchnic region. By squeezing the abdomen the aortic pressure returned to normal. Hill and Barnard also demonstrated that if rabbits raised in a hutch were placed in a vertical position, feet down, the animals would die in a very...1 HILLBARNARD LH: The influence of the force of gravity on the circulation; part 2, Jr. Physiol., 1897, xxi, 323-353. CrossrefGoogle Scholar2 CRAMPTON CW: A test of condition: preliminary report, Med. News, 1905, lxxxvii, 529-535. Google Scholar3 CRAMPTON CW: The gravity resisting ability of the circulation; its measurement and significance (blood ptosis), Am. Jr. Med. Sci., 1920, clx, 721-737. CrossrefGoogle Scholar4 MORTENSEN MA: Blood pressure reactions to passive postural changes. An index to myocardial efficiency, Am. Jr. Med. Sci., 1923, clxv, 667-675. CrossrefGoogle Scholar5 TURNER AH: The adjustment of heart rate and arterial pressure in healthy young women during prolonged standing, Am. Jr. Physiol., 1927, lxxxi, 197-214. CrossrefGoogle Scholar6 BRADBURYEGGLESTON SC: Postural hypotension; a report of three cases, Am. Heart Jr., 1925, i, 73-86. CrossrefGoogle Scholar7 GHRISTBROWN DGGE: Postural hypotension with syncope: its successful treatment with ephedrine, Am. Jr. Med. Sci., 1928, clxxv, 336-349. CrossrefGoogle Scholar8 MACWILLIAM JA: Postural effects on heart-rate and blood-pressure, Quart. Jr. Exper. Physiol., 1933, xxiii, 1-33. Google Scholar9 HENDERSON Y: The volume of the circulation and its regulation by the venopressor mechanism, Jr. Am. Med. Assoc., 1931, xcvii, 1265-1269. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOrthostatic hypotension treated with benzedrine 1 November 1935Volume 9, Issue 5Page: 638-640KeywordsAortaBlood pressurePostural controlRabbitsSpinal cord ePublished: 1 December 2008 Issue Published: 1 November 1935 PDF downloadLoading ...
Treatment of hirsutism with spironolactone
Authors: D. C. Cumming
Journal: JAMA (1982)

Clinical and endocrine evaluations of 39 patients with hirsutism were performed to determine the effectiveness and site(s) of action of an antiandrogenic compound, spironolactone. Treatment with spironolactone at a dose of 200 mg/day resulted in a clear beneficial effect on the quantity and quality of facial hair growth in 19 of 20 patients with moderate to severe hirsutism. Regression of hirsutism in terms of diameter, density, and the rate of facial hair growth was noticeable within two months. The maximal effect was observed at six months and was maintained at 12 months of treatment. Spironolactone was equally effective in reducing hirsutism in women with polycystic ovary syndrome and idiopathic hirsutism. These clinical observations were associated with a prompt and sustained reduction in levels of androgen of ovarian origin without affecting levels of adrenal androgen and cortisol. Apart from diuresis, which was limited to the first few days of treatment, there were no discernible side effects during the one year of this study. Our results indicate that spironolactone is a highly effective and safe agent for the treatment of hirsutism through its inhibitory action on both ovarian androgen secretion and peripheral androgen action. (<i>JAMA</i>1982;247:1295-1298)
Text-Book of Psychiatry. A Psychologic Study of Insanity for Practitioners and Students.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1946)

s note (March 2, p. 342) on poisoning from tetra- ethyl lead in persons exposed to petrol fumes, this question has been very fully investigated in America, and it has been found that petrol.as usually handled in commerce carries no risk of lead-poisoning.In all suspected cases so far it has been established that plumbism was not a factor in the production of the illness (Machle, W.,
Health literacy and cancer care: Do patients really understand
Authors: E. A. Heckinger, C. L. Bennett, T. Davis, M. S. Wolf
Journal: Journal of Clinical Oncology (2004)

6045 Background: Cancer patients contend with physical and psychological symptoms due to the disease and treatment. Despite these difficulties, patients must routinely interact with medical providers and possess a basic understanding of treatments to participate in healthcare decisions. Failure to engage in these activities has been linked to poor health outcomes and treatment satisfaction. We evaluated the relation between literacy and patients' perceived ability to understand information and initiate discussions with the oncologist concerning cancer treatment. Methods: 161 patients with existing diagnosis of cancer (lung 10%, colorectal 7%, prostate 24%, renal 2%, breast 6%, gyn 6%) were recruited for face-to-face interviews from oncology clinics in Chicago, IL and Shreveport, LA. Mean age was 66 years (SD=16.5). 58% were Black, 38.5% White, and 2.2% of Hispanic origin. ≤15% were female. Patients completed a reading screening test and 15-item provider communication self-efficacy scale that measures 1) coping ability, 2) cancer information-seeking behavior, 3) understanding of cancer information, and 4) social support. Results: 50% of the patients (48.6%) identified one or more problems coping with cancer. 56% reported trouble communicating with friends and family about cancer, 45.9% had problems understanding information about the disease and/or treatment, while 36.7% were uncomfortable seeking information from their oncologist. Multiple logistic regression analysis was performed to adjust for race (black, other), age (<65, ≥65), and literacy level (<9th grade, ≥9th grade). Low literacy was the only significant predictor of problems with coping (AOR 2.11, 95% CI 1.16–4.18), social support (AOR 2.54, 95% CI 1.26–5.10), and understanding of cancer information (AOR 2.12, 95% CI 1.17–4.20). Conclusions: Patients with low literacy skills are at increased risk for 1) not understanding their disease and treatment, 2) not conveying concerns to the oncologist, and 3) difficulty coping with cancer. Providers of cancer treatment should consider screening literacy in clinical practice. However, screening should only be used if paired with low literacy communication strategies. No significant financial relationships to disclose.
This Week in &lt;EMPH&gt;JAMA&lt;/EMPH&gt;
Journal: JAMA (2005)

Accumulating evidence that certain synthetic and plant-derived compounds have hormonelike effects is heightening concerns that exposure to these substances, especially early in life, might pose long-term health risks. SEE PAGE 291 Achieving a Healthy DietA current understanding of nutrient requirements and interactions supports consumption of essential nutrients from a varied diet rather than dietary supplements.
Editorial: Treatment of genital herpes.
Journal: BMJ (1974)

Familial Mledullary Carcinoma of the ThyroidMedullary carcinoma of the thyroid is a tumour of the para- follicular or C cells, which produce calcitonin.It tends to occur in families, and is associated with phaeochromocytomas, parathyroid hyperplasia or adenomas, and occasionally with Gushing's syndrome.1 2 It has been classified3 as the multiple-endocrine-adenomatosis syndrome, type II, as distinct from the type I syndrome characterized by pituitary, parathyroid, pancreatic islet cell, and adrenal adenomas.Some patients with medullary carcinoma of the thyroid have a combination of multiple buccal and orbital neuromas, an unusual facies with thick lips, a marfanoid habitus, a proximal myopathy, and megacolon.Most cases with multiple neuro- mas have been sporadic, and this could prove to be an entity distinct from the multiple-endocrine-adenomatosis syndrome
Injuries From Fireworks in the United States
Journal: JAMA (2000)

Fireworks traditionally are used in the United States to celebrate Independence Day on July 4th. The U.S. Consumer Product Safety Commission (CPSC) estimates that 8500 persons in the United States are treated in emergency departments each year for fireworks-related injuries (1). Of all fireworks-related injuries, 70%-75% occur during a 30-day period that surrounds the July 4th holiday (June 23-July 23) (2). Seven of every 100 persons injured by fireworks are hospitalized, approximately 40% of those injured are children aged < or = 14 years, and males are injured three times more often than females (1). The injury rate is highest among boys aged 10-14 years (3). Most commonly, injuries from fireworks affect the hands (34%), face (12%), and eyes (17%) (4). Injuries are more frequent and more severe among persons who are active participants than among bystanders (3).
Surgeons try immune therapy for breast cancer
Authors: B. I. Chi-Lum
Journal: JAMA (1994)

IMMUNE THERAPY may hold promise for preventing metastasis in breast cancer patients, according to new animal studies. The treatment opens up the possibility of improving survival after primary breast tumors are excised, said H. Kim Lyerly, MD, clinical director of the Molecular Therapeutic Program at Duke University Medical Center, Durham, NC. "It may also increase the utility of surgery for women with metastatic disease because it can prevent further metastases from forming," he added. Lyerly and his colleagues presented their findings in Chicago, Ill, at the annual Clinical Congress of the American College of Surgeons. The researchers surgically implanted breast cancer tumor cells onto the feet of mice. These cells developed into palpable breast tumors within 7 days of implantation. After 20 days, the researchers removed the tumors. The mice later developed lung metastases in a manner similar to the clinical course of women with breast cancer metastases. Because cytokine
THE ASSOCIATION OF AMERICAN PHYSICIANS.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1783: A combination therapy of atypical protein kinase inhibitor and phosphatidylinositol-3- kinase inhibitor reduces multidrug resistance in renal cell carcinoma (RCC)
Authors: Khandker Mohammad Khalid
Journal: Cancer Research (2019)

Abstract Renal Cell Carcinoma (RCC) is the most common type of kidney cancer (85%) of which 75% of the cases involve conventional clear cell RCC (ccRCC). Choice of treatments recommended for clear cell carcinoma and non-clear cell carcinoma are partial nephroctomy (Stage I), radical nephoroctomy (Stage II and III) and chemotherapy (stage IV). Phosphatidylinositol-3- kinase (PI3K) inhibitors are one of the most prospective candidate in the therapy of ccRCC as the PI3CA gene for p110α (a class of the catalytic sub unit of PI3K) is mutated in most of the cases. Hence, PI3K inhibitors like Alpelisib (BYL 719) can be a treatment. But current therapeutic prospects are limited to the fact that RCC is a chemotherapy-resistant cancer type that acts as a barrier for successful treatment with this inhibitor. In addition, of all the other aPKCs, PKC ί/λ and PKC ζ are reported to be frequently overexpressed in most cancer cells and to have different significant roles in tumor progression and carcinogenesis of different type of cancers. Caki-1 metastatic clear cells were treated with PKC ζ inhibitor [8-hydroxynaphthalene-1,3,6-trisulfonic acid] or ζ-stat, Alpelisib and combination of both ζ-stat and Alpelisib at different doses. The results of WST-1 shows that the combination of ζ-stat (7.5 µM) and Alpelisib (10.0 µM) has the most cytotoxicity compared to the single therapy of Alpelisib. Annexin-V/PI assay also suggested that the combination therapy caused greater percentage of apoptosis and cell death compared to the single therapy of Alpelisib. The efflux proteins, (p-glycoprotein (P-gp) and ATP-binding cassette sub-family G member 2 (ABCG2), are responsible for developing cell resistance in Caki-1 cells had reduced expression in the cells when treated with the combination treatment of Alpelisib and ζ-stat. Therefore, combination therapy of Alpelisib and an aPKC inhibitor for metastatic ccRCC can reduce expression of multi drug resistance (MDR) proteins/efflux transporter P-gp and ABCG2. Hence, this combination may be a possible treatment that might help eradicating MDR of ccRCC. Thus, a combination of Alpelisib and an aPKC inhibitor can be a two pronged approach reducing the cell proliferation and resistance. Citation Format: Khandker Mohammad Khalid. A combination therapy of atypical protein kinase inhibitor and phosphatidylinositol-3- kinase inhibitor reduces multidrug resistance in renal cell carcinoma (RCC) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1783.
Dr. Sam Naguib-Rizkalla Is Not Dead
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Screenings Lag Behind National Goals Set for 2020
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nutritional support of the hospitalized patient. The team concept
Authors: A. E. Nehme
Journal: JAMA (1980)

Two groups of patients receiving total parenteral nutrition (TPN) were compared in a prospective study for a period of 24 months. The TPN in one group of 211 patients was exclusively managed by a nutrition support team. A variety of physicians managed the TPN of 164 patients in the other group. The complication rate of both groups was compared. The second group had a much higher incidence of all complications. The study concludes that a protocol strictly adhered to by knowledgeable persons is necessary for the proper administration of TPN in the hospitalized patient. (<i>JAMA</i>243:1906-1908, 1980)
Mental Defect
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI October 1 to November 1, 1969
Journal: JNCI Journal of the National Cancer Institute (1969)

Manuscripts Approved for JNCI October 1 to November 1, 1969 Get access JNCI: Journal of the National Cancer Institute, Volume 43, Issue 6, December 1969, Pages 1407–1408, https://doi.org/10.1093/jnci/43.6.1407 Published: 01 December 1969
CLINICAL LECTURES ON SURGERY NOW IN COURSE OF DELIVERY AT QUEEN'S COLLEGE, BIRMINGHAM
Authors: L. Parker
Journal: BMJ (1855)

GENTLNXBN,-I intend to draw your attention in this leeture to a case of venereal ulceration of the cartilages of the larynx, which you have lately had an opportunity of ob- serving.I shall first detail to you the history of the case.In the second part of the lecture, I shall give you a ge- neral history, I may say, of syphilitic diseases of the larynx, and of those conditions of the throat which immediately precede it, and which may be considered in some mea- sure as causes, or, at any rate, precursory or premonitory symptoms of syphilitic disease of the larynx itself.The subject of the present case was a man 30 years 'of age, by trade a cook.He consulted me some three months ago, with phagedenic ulceration of the fauces and pharynx.He was extremely emaciated, and said he had ad diseased throat for seven or eight years.He first con- tracted syphilis eight years ago-that is, eight years before I saw him.I do not know what the primary symptoms were; but it appeared that, six months after their appear- ance, he had skin disease, which was said to be venereal, and no doubt was.This disappeared; but, soon after that,