tbuckley/cabot-search huggingface dataset:
Diagnostic and therapeutic technology assessment. Reassessment of automated percutaneous lumbar diskectomy for herniated disks
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P115: Selective Vasoconstriction of the Ductus Arteriosus in the Rat by Stimulation of Thromboxane A <sub>2</sub> Receptor
Authors: Tomohiro Yokota, Takashi Aida, Utako Yokoyama, Susumu Minamisawa
Journal: Circulation Research (2011)

Objective: Patent ductus arteriosus (PDA) is a common life-threatening complication of premature infants. Cyclooxygenase inhibitors are frequently used for pharmacologic therapy of PDA to inhibit the synthesis of prostaglandin E 2 (PGE 2 ) that is the most potent vasodilator in the DA. However, they often cause severe side-effects. Thromboxane A 2 (TXA 2 ), a vasoconstrictive lipid mediator, induces vascular contraction via TXA 2 receptor (TP). TXA 2 is also known to counteract prostacycline, a vasodilative lipid mediator. Therefore, we hypothesized that TXA 2 -TP stimulation can be an alternative strategy to induce DA closure by counteracting PGE 2 . Methods and Results: Quantitative RT-PCR analysis revealed that the expression of TP mRNA was higher in the DA than in the aorta during fetal periods. When the selective TP agonist U46619 was intraperitoneally injected into Wister rat fetuses at embryonic day 19th (e19) and e21, we found that U46619 selectively constricted the fetal DA in a dose-dependent manner even though the level of circulating PGE 2 was supposed to be high. The vasoconstrictive effect of U46619 was weaker at e19 than at e21 in the DA, suggesting that immature DA is less sensitive to TP stimulation. Importantly, U46619 also showed vasoconstrictive effect on two different types of postnatal PDA models: immature PDA and hypoxia-induced PDA. These effects of U46619 were stronger than the effect of indomethacin that is the most common cyclooxygenase inhibitor. In addition, we found that U46619 exhibited little vasoconstrictive effect on other vessels such as the aorta, pulmonary arteirs, carotid arteries, renal arteries, and portal veins. Furthermore, U46619 was not likely to induce microthrombosis in the pulmonary capillary arteries. These results suggest that TP agonists could selectively promote the DA constriction without severe complications and be an alternative potent vasoconstrictor for patients with PDA.
Gastrointestinal bleeding secondary to pancreatitis
Authors: W. A. Kisken
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Occasionally patients with the diagnosis of pancreatitis have guaiac positive reaction in stool specimens and usually anemia which in spite of thorough investigation defies accurate diagnosis. The case presented below typifies such a patient, but the etiology of gastrointestinal bleeding was eventually determined. In September 1964, A 48-year-old man, had the onset of stabbing epigastric pain on the left side which radiated to the lower left side of the posterior part of the chest. Intense pain lasted for 30 to 60 minutes with mild discomfort lasting as long as 24 hours. The attacks were precipitated by fatty foods and were preceded by nausea. In June 1965, he was admitted to the local hospital for this pain. A thorough examination which included an x-ray examination of the upper gastrointestinal tract, a barium sulfate enema examination, a cholecystogram, and a pyelogram after intravenous injection of a contrast medium did
The prognosis of systemic sclerosis
Authors: N.R. Rowell
Journal: British Journal of Dermatology (1974)

Journal Article The prognosis of systemic sclerosis Get access N.R. Rowell N.R. Rowell General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue s10, 1 July 1974, Page 18, https://doi.org/10.1111/j.1365-2133.1974.tb12479.x Published: 01 July 1974
EPCT-15. THE REMIND TRIAL: MULTI-ANTIGEN TARGETED T CELLS FOR PEDIATRIC CNS TUMORS
Authors: Melanie Grant, Maria Fernanda Fortiz, Lu Wang, Haili Lang, Anushree Datar, Emily Reynolds, Madeline Terpilowski, Chris Lazarski, Jay Tanna, Adriana Pitino, Nan Zhang, Fahmida Hoq, Patrick Hanley, Lindsay Kilburn, Roger Packer, Brian Rood, Catherine Bollard, Eugene Hwang
Journal: Neuro-Oncology (2020)

Abstract BACKGROUND Patients with relapsed CNS malignancies or DIPG face terrible prognoses. We hypothesized that T cells specific for 3 tumor-associated antigens (TAA), WT1, PRAME and survivin, would be safe and elicit anti-tumor immunity. METHODS Patients (n=9) have received autologous tumor antigen-associated T cells (TAAT) (up to 4x107/m2) for newly diagnosed DIPG (Group A) or recurrent CNS malignancies (Group B) on a Phase I dose-escalation study (NCT03652545) and were monitored for safety and response. RESULTS/ DISCUSSION 9/9 patients who received TAAT completed the 45-day safety monitoring phase with no dose-limiting toxicities. Infused cells were predominantly CD3+ T cells (median 96%; range: 87–99%), with CD4+ and CD8+ comprising 16% (range: 5–87%) and 40% (range: 4–67%) of the CD3+ cells, respectively. TAAT with specificity for 1–3 TAAs, at varying frequencies, was demonstrated in 8/9 TAAT by anti-IFN-γ ELISPOT. Plasma cytokine profiles demonstrated infusion-related immune cytokine responses. In summary, TAAT are safe and may elicit anti-tumor responses in vivo. To confirm TAAT-driven effects, we are evaluating plasma proteomic profiles for immune-response signatures and assessing unique T cell receptor rearrangements of infused TAAT. Response assessment and dose escalation are ongoing.
Aging of the liver: Age-associated mitochondrial damage in intact hepatocytes
Authors: J Sastre
Journal: Hepatology (1996)

Mitochondrial damage may be a major cause of cellular aging. So far, this hypothesis had only been tested using isolated mitochondria. The aim of this study was to investigate the involvement of mitochondria in aging using whole liver cells and not isolated mitochondria only. Using flow cytometry, we found that age is associated with a decrease in mitochondrial membrane potential (30%), an increase in mitochondrial size, and an increase in mitochondrial peroxide generation (23%). Intracellular peroxide levels were also increased. The number of mitochondria per cell and inner mitochondrial membrane mass did not change. Gluconeogenesis from glycerol or fructose (mitochondrial- independent) did not change with age, whereas it did from lactate (mitochondrial-dependent). The change in the rate of gluconeogenesis was not accompanied by changes in any of the following parameters: phosphoenolpyruvate carboxykinase or pyruvate carboxylase activities or mitochondrial ATP/ADP or cytosolic NADH/NAD+ ratios. This was caused by a decreased rate of malate export (to 20% of the controls) from mitochondria. The impairment of the mitochondrial malate transporter is posttranscriptional because its expression in Xenopus oocytes using polyadenylated RNA from livers of young or old animals did not change. Ketogenesis from oleate also fell in hepatocytes from old rats. Our results show, for the first time in intact cells, a correlation between age-associated impairment of cell metabolism and specific changes in mitochondrial function and morphology, supporting the hypothesis that mitochondrial damage plays a key role in aging.
RARE-56. RECURRENCE PATTERN AND SURVIVAL FOR RELAPSED INTRACRANIAL NON-GERMINOMATOUS GERM CELL TUMORS: A SINGLE-INSTITUTION EXPERIENCE
Authors: Lei Wen, Zhaoming Zhou, Juan Li, Cheng Zhou, Mingyao Lai, Linbo Cai
Journal: Neuro-Oncology (2019)

Abstract PURPOSE Intracranial non-germinomatous germ cell tumors (NGGCTs) have lower overall survival than germinoma because higher recurrence usually occurs after first line therapy in NGGCTs. METHODS Between January 2003 and December 2017, 23 patients with clinically or pathologically diagnosed recurrent NGGCTs after first line therapy were reviewed at our institution. Data of first line treatment, salvage treatment, clinicopathological features and survival were collected and analyzed. RESULTS First line therapy including craniospinal irradiation (CSI) in 15 patients, surgery in 3 patients, Gamma knife in 2 patients, chemotherapy in 2 patients and whole brain radiotherapy (WBRT) in 1 patient. The median time to recurrence was 13.8 months (5.8 to 89.2). With reference to the distribution of relapsed lesions, there were 8 patients within the primary site, 6 with distant intracranially, 1 ventricularly, 5 in spinal cords, 1 with dual sites in both primary site and intracranially, and 1 patient evidenced only serologically positive. Three patients did not receive further treatment and was lost during follow-up. Of the other patients, 16 patients received salvage chemotherapy with or without surgery, 4 received CSI or radiosurgery. After median follow up of 54 months, 7 patients died of disease progression. The 4-year overall survival rate after recurrence was 55.4%. CONCLUSION Protracted follow-up is recommended because late recurrence is not uncommon. Primary tumor site and distant intracranial are the most prevalent relapsed location. Patients who relapsed could benefited from salvage chemotherapy.
Clinical dose ranging studies with finasteride, a type 2 5α-reductase inhibitor, in men with male pattern hair loss☆, ☆☆, ★, ★★
Authors: J ROBERTS, V FIEDLER, J IMPERATOMCGINLEY, D WHITING, E OLSEN, J SHUPACK, D STOUGH, R DEVILLEZ, R RIETSCHEL, R SAVIN
Journal: Journal of the American Academy of Dermatology (1999)
A CORRELATIVE STUDY BY ELECTRON AND LIGHT MICROSCOPY OF THE DEVELOPMENT OF TYPE 5 ADENOVIRUS
Authors: Gabriel C. Godman, Councilman Morgan, Peter M. Breitenfeld, Harry M. Rose
Journal: The Journal of Experimental Medicine (1960)

The evolution of the intranuclear lesion produced by type 5 adenovirus in HEp-2 and HeLa cells is described as seen in the light microscope and the bodies formed in the course of the infection characterized histochemically. Some 12 hours after infection acidophilic protein bodies, without appreciable nucleic acid, first appear in the nucleus and coalesce into a network. Within or in association with this material, DNA-containing masses (viral aggregates) are formed which rapidly increase in amount and then coalesce. At the same time, a protein is produced, histochemically different from that of the acidophilic or basophilic structures mentioned, within the infected nucleus, which constitutes a matrix within which regular cytstals of a protein, (presumably non-viral) materialize. These structural and histochemical features are correlated with details which have been observed in parallel studies with the electron microscope.
Landmark article Aug 5, 1968: A definition of irreversible coma. Report of the Ad Hoc Committee of the Harvard Medical School to examine the definition of brain death
Journal: JAMA (1984)

The report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Death, originally published in the 5 August 1968 issue of JAMA, is reprinted as a landmark article. The report defines "irreversible coma" as a new criterion for death, lists steps to be taken by physicians to diagnose this condition, and mentions two early instances of the concept's appearance in judicial rulings.
PTU-031 Total dietary sugar intake and the aetiology of Crohn's disease: data from a European prospective cohort study (EPIC)
Authors: A R Hart
Journal: Gut (2010)

<h3>Introduction</h3> There are plausible biological mechanisms for how diet may be involved in the aetiology of Crohn9s disease, with numerous case-control studies reporting positive associations with an increased sugar intake. However, these findings may be subject to recall biases for sugar intake leading to spurious results. The aim of this investigation was to eliminate this error by conducting the first multicentre European prospective cohort study of the dietary intake of total sugar and the risk of developing Crohn9s disease. <h3>Methods</h3> A total of 333 682 initially well men and women aged 20–80 years were recruited into the EPIC Study (European Prospective Investigation into Cancer). The participants were resident in The UK, Sweden, Denmark, Germany, Italy and France. At recruitment they completed food frequency questionnaires on diet from which their sugar intake was determined. Each case was matched with four controls and the odds ratios (ORs) calculated using conditional logistic regression, adjusted for total energy intake and cigarette smoking. <h3>Results</h3> In the cohort, a total of 93 initially well participants developed Crohn9s disease (71% women) at a median age of 56.7 years (range 27.0–78.7 years). The terminal ileum was affected in 44% of patients. The adjusted OR for the highest vs the lowest quartile of intake of total sugar was 1.01 (95% CI 0.41 to 2.47, p=0.98) with a trend across quartiles of 0.94 (95% CI 0.71 to 1.23, p=0.62). There were no associations with either the dietary intakes of total carbohydrates (OR for trend=0.87, 95% CI 0.62 to 1.21) or starch (OR for trend=1.16, 95% CI 0.78 to 1.72). <h3>Conclusion</h3> This prospective cohort study found no association with the intake of total dietary sugar and the risk of developing Crohn9s disease. Therefore, reports of a positive association from case-control studies is probably indicative of recall bias due to an increased sugar consumption by patients with established disease and therefore sugar does not have a role in the aetiology of Crohn9s disease.
Yellow Fever
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Queries and Minor Notes
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Ripening of Fruits
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3470: The antagonistic functional duality of p21WAF1/CIP1 in cells derived from multicellular tumor spheroids
Authors: Viswanath Das, Narendran Annadurai, Dušan Holub, Marián Hajdúch
Journal: Cancer Research (2019)

Abstract The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a key mediator of p53-dependent cell cycle arrest after DNA damage, in addition to p53-independent mechanisms. Being one of the major transcriptional targets of p53 and due to its anti-cell proliferative activity, p21 was considered initially as a potent tumor suppressor. However, emerging studies now show the anti-apoptotic and pro-cell proliferative effects of p21, highlighting the oncogenic role of p21 in cancer. In particular, p21 results in genomic instability and the development of aggressive and chemo-resistant traits in a subset of highly proliferating tumor cells through p53-independent pathways. The cellular localization of p21 has been proposed to be critical either in promoting cell survival or in inhibiting cell growth. Herein, using a combination of gene knockout, cytotoxicity assay, immunofluorescence, immunoprecipitation, and mass spectrometry techniques, we study the consequence of nuclear and cytoplasmic localization of p21 on cell survival and drug response in cells derived from multicellular spheroids of multiple human cancer cell lines. Our study shows that cells derived from multicellular spheroids show an increased induction of p21 despite the reversal from three-dimensional to two-dimensional cultures. The p21-overexpressing, highly proliferative cells are significantly resistant to a number of standard anti-cancer agents. Further analysis shows that the majority of p21 in this subset of spheroid-derived cells is localized in the cytoplasm and forms a potential 'anti-apoptosome'-like complex with mitochondrial apoptosis-associated proteins. These findings add to the shifting paradigm on the oncogenic role p21 due to cellular mislocalization in tumor cells. Citation Format: Viswanath Das, Narendran Annadurai, Dušan Holub, Marián Hajdúch. The antagonistic functional duality of p21WAF1/CIP1 in cells derived from multicellular tumor spheroids [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3470.
Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration
Authors: F. Facchini
Journal: JAMA (1991)

<h3>Objective.</h3> —To define the relationship, if any, between insulin-mediated glucose disposal and serum uric acid. <h3>Design.</h3> —Cross-sectional study of healthy volunteers. <h3>Setting.—</h3> General Clinical Research Center, Stanford (Calif) University Medical Center. <h3>Participants.</h3> —Thirty-six presumably healthy individuals, nondiabetic, without a history of gout. <h3>Measurements.</h3> —Obesity (overall and regional), plasma glucose and insulin responses to a 75-g oral glucose load, fasting uric acid concentrations, plasma triglyceride and high-density lipoprotein—cholesterol concentrations, systolic and diastolic blood pressure, insulin-mediated glucose disposal, and urinary uric acid clearance. <h3>Results.</h3> —Magnitude of insulin resistance and serum uric acid concentration were significantly related (<i>r</i>=.69;<i>P</i>&lt;.001), and the relationship persisted when differences in age, sex, overall obesity, and abdominal obesity were taken into account (<i>r</i>=.57;<i>P</i>&lt;.001). Insulin resistance was also inversely related to urinary uric acid clearance (<i>r</i>= -.49;<i>P</i>&lt;.002), and, in addition, urinary uric acid clearance was inversely related to serum uric acid concentration (<i>r</i>= -.61;<i>P</i>&lt;.001). <h3>Conclusions.</h3> —Urinary uric acid clearance appears to decrease in proportion to increases in insulin resistance in normal volunteers, leading to an increase in serum uric acid concentration. Thus, it appears that modulation of serum uric concentration by insulin resistance is exerted at the level of the kidney. (<i>JAMA</i>. 1991;266:3008-3011)
Delay in conception for former 'pill' users
Authors: S. Linn
Journal: JAMA (1982)

Interview data from 3,214 married women having planned pregnancies and singleton deliveries who had no history of fertility treatment and who conceived more than two weeks after cessation of contraception were analyzed. The interval from cessation of contraception to conception was 13 months or greater for 24.8% of prior "pill" users vs 10.6% for former users of all other methods. As compared with former users of other methods, pill users had a notably lower monthly percentage of conceptions for the first three months and somewhat lower percentage from four to ten months. Results were not altered when potential confounding variables were controlled by logistic regression. At least 15 months of unsuccessful trials might be a more appropriate working definition of infertility for previous pill users rather than the 12-month interval generally accepted for this purpose. (<i>JAMA</i>1982;247:629-632)