tbuckley/cabot-search huggingface dataset:
Die gynäkologische Operationstechnik der Schule Ernst Wertheims.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Woman's Auxiliary
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental Pneumoconiosis
Authors: Max Millard
Journal: JAMA (1970)

This book reviews experimental pneumoconiosis from the 1920's to the early 1960's. An introductory chapter recounts the ancients' awareness of the dangers of dust to miners. A description of the minerals causing pneumoconiosis and of the related industries is valuable. Experimental methods for studying silicosis are described minutely. Variations in species reactions are noted; perfect silicotic nodules are found in the white rat, diffuse fibrosis in rabbits. Species vary in effectiveness of nasal filtration of dust and metabolic rate and phagocytic activity in the experimental animal should match that of man. The pathology of silicosis is superficially discussed but there is an excellent account of experimental silicosis. Theories of pathogenesis of various pneumoconioses are reviewed, as are the many suggested treatments. Insufficient emphasis is made of the nonspecificity of the asbestos body. The few cases where pure carbon could have been fibrogenic are reviewed. Many would dispute the dogma that
Chemical and Toxicological Characterization of Residential Oil Burner Emissions: II. Mutagenic, Tumorigenic, and Potential Teratogenic Activity
Authors: Andrew G. Braun, William F. Busby, Howard L. Liber, William G. Thilly
Journal: Environmental Health Perspectives (1987)

Extracts of effluents from a modern residential oil burner have been evaluated in several toxicological assay systems. Bacterial mutagens were detected in extracts from both the particulate and vapor phase emissions. Effluents from continuous operation were an order of magnitude less mutagenic than those from cyclic (5 min on, 10 min off) operations. No difference in the yield of bacterial mutagens per gram of fuel burned was found between cyclic operation under low and moderate sooting conditions. On the basis of elution behavior from alumina it appeared that the bacterial mutagens collected from high sooting effluents were more polar than those from low sooting effluent. An extract that was mutagenic in bacteria did not induce a significant increase in mutation frequency to human lymphoblasts. No evidence of tumorigenicity was observed in a limited number of newborn mice after IP injection of effluent extract when compared to historical control data. Putative nonmutagenic teratogens were detected in effluent using an attachment inhibition assay. The level of these agents was reduced in effluents from continuous oil burner operation.
Abstract 713: S 18886 Inhibits Thromboxane A <sub>2</sub> Receptor-dependent Tissue Factor Expression, Procoagulant Activity And NADP(H) Oxidase Activation In Stimulated Endothelial Cells
Authors: Serena Del Turco, Giuseppina Basta, Guido Lazzerini, Laurent Chancharme, Laurence Lerond, Raffaele De Caterina
Journal: Circulation (2007)

Background Tissue factor (TF) expression and surface exposure are key events in thrombosis, likely contributing to clinical events in vascular disease. Thromboxane (TX)A 2 , an unstable metabolite of arachidonic acid released from vaious cell types, is known for its pro-aggregating and vasoconstrictor properties. Cellular effects of TXA 2 are effected through the TP (TX-prostaglandin endoperoxide) receptor, also expressed in endothelial cells (EC). The TP receptor antagonist S 18886 (Terutroban) demonstrated antithrombotic and antiatherogenic effects in activated EC. As the underlying molecular mechanisms are largely unexplored, we studied the effects of TP agonism and of antagonism on TF expression and procoagulant activity in human umbilical vein endothelial cells (HUVEC), and signal transduction pathways involved. Methods and Results HUVEC ± 30 min pretreatment with the TP antagonist S 18886 were stimulated with the TP receptor agonist U 46619 or TNF-α for 6 hours. TF total expression and surface exposure were assessed by enzyme immunoassays, and TF-dependent procoagulant activity by the generation of Factor Xa. HUVEC exposed to U 46619 featured a concentration-dependent increase in TF total expression and surface exposure. These were associated with enhanced procoagulant activity. S 18886 (1 μmol/L) significantly reduced U 46619 (1 μM)-induced TF expression (−20% ± 7%, P&lt;0.05) and procoagulant activity (−32% ± 11%, P&lt;0.05). Interestingly, S 18886 (1 μmol/L) prevented the increase of TF expression after TNF-α (20 ng/mL) stimulation (−25% ± 9%, P&lt;0.05). Both U 46619- and TNF-α-induced TF expression were mediated by the increase of intracellular reactive oxygen species (ROS), and this was inhibited by S 18886 (−44% ± 6% and −24% ± 5% P&lt;0.05, respectively). S 18886 decreased the membrane association of p47-phox component of NADP(H) oxidase, accounting for the reduced production of ROS. Conclusions Our results show that endothelial TP receptor mediates TF expression, surface exposure and activity stimulated both by TP agonists and by TNF-α. This occurs through NADP(H) oxidase activation and the consequent generation of ROS. These procoagulant and oxidant pathways are inhibited by the TP receptor antagonist S 18886.
New Zealand Medical Journal, Wellington
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
London Medical Society: Dr. Thompson on Perforation of the Stomach
Journal: BMJ (1842)

peritonitis.He, however, considers the extreme anxiety and distress of the patient's countenance as more pathognomonic of the occurrence than the vomiting or state of the pulse. LONDON MEDICAL SOCIETY.SPONTANEOUS PERFORATION OF THE STOMACH.Dr. CLt1TTERBUC}.communicated the following case from Dr
Developing Brain as a Target of Toxicity
Authors: Patricia M. Rodier
Journal: Environmental Health Perspectives (1995)

The human brain forms over an unusually long period compared to other organs.While most of the basic structure is laid down before birth, neuron proliferation and migration continue in the postnatal period.The blood-brain barrier is not fully developed until the middle of the first year of life.The number of synaptic connections between neurons reaches a peak around age two and is then trimmed back by about half.Similarly, there is great postnatal activity in the development of receptors and transmitter systems as well as in the production of myelin.Many of the toxic agents known to damage the developing brain interfere with one or more of these developmental processes.Those with antimitotic action, such as X-ray and methyl mercury, have distinctly different effects on structure depending on which neurons are forming at the time of exposure.Vulnerability to agents that interfere with cell production decreases rapidly over the early postnatal period.Other toxic substances, such as psychoactive drugs and agents that alter hormone levels, are especially hazardous during synaptogenesis and the development of transmitter systems, and thus continue to be damaging for years after birth.Still other toxic substances such as lead, seem to have their greatest effects during even later stages of brain development, perhaps by interfering with the trimming back of connections.Guidelines designed to protect human populations from developmental neurotoxicity need to take into account the changing sensitivity of the brain as it passes through different developmental stages, as well as the fundamental differences in the effects of toxicants on the mature and the developing brain.
Non-motile sperms persisting after vasectomy: do they matter?
Authors: I S Edwards, J L Farlow
Journal: BMJ (1979)

Disappearance of spermatozoa from ejaculate after vasectomyThe disappearance of spermatozoa from the ejaculate after vasectomy is said to be influenced by age, frequency of ejaculation, and time since operation.' 1 Since their relative importance is not clear we examined the histories of 624 men who underwent vasectomy at the Margaret Pyke Centre from July 1971 to October 1972 to investigate the independent effects of these factors on the clearance of spermatozoa. Methods and resultsDetails of data collection, surgical techniques, and methods of semen
WEDNESDAY 5TH APRIL
Journal: Gut (1995)

Conventional serology for Hepatitis C Virus (HCV) by enzyme-immunoassay (ELISA) provides evidence of infection, past or present, but does not indicate infectivity.Recombinant immunoblot assay (RIBA) correlates better than ELISA with the presence of HCV genome by the polymerase chain reaction (PCR) which currently tends to be the "gold-standard" for infectivity.However, both RIBA and PCR are slow, subjective, labour intensive and therefore expensive.In most viral.infections the appearance of IgM antibodies provide an indication of acute infection, while persistently low levels are often found in chronicity.Am: To evaluate a new test for IgM anti-HCV (Abbott Diagnostics, Weisbaden, Germany) on 42 anti-HCV positive recipients of anti-D immunoglobulin, in comparison with "in house" PCR and Roche Amplicor PCR.Results: Of the 42 patients, 29 (69%) were positive for IgM anti-HCV and by both PCR methods.Five patients were negative for IgM anti-HCV and by PCR.In 7 cases PCR was positive but 1gM anti-HCV was not found.In one case, IgM was positive and PCR was negative but the patient had been treated with interferon.Thus there was a 100% positive correlation between the presence of IgM anti-HCV and the presence of HCV genome in untreated chronic HCV infected patients (X2=1 1.04, p<0.001) but not necessarily the reverse.Conclusign: We conclude that IgM anti-HCV testing (at approximately one-third of the cost of PCR) may provide an economical aid to minimising the need for a significant proportion of PCR testing in chronic HCV infection.
Two Generations of Data Aid Framingham's Focus on Genes
Authors: R. Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detecting deception
Authors: Kenneth J. Gergen
Journal: Behavioral and Brain Sciences (1997)

I find three major shortcomings in Mele's account. First, verbal ambiguities suggest that the analysis is irrelevant to self-deception and/or that the traditional conception is subtly reinstated. Second, the data offer no means of establishing the superiority of the present account. Finally, as political rhetoric, Mele's proposal not only operates to disqualify others, but establishes science as their judge.
Different recurrence pattern after neoadjuvant chemoradiotherapy compared to surgery alone in esophageal cancer patients.
Authors: John Theodorus Plukker, Justin Smit, Sahin Guler, Jannet Beukema, Veronique E. Mul, Johannes Burgerhof, Geke A. Hospers
Journal: Journal of Clinical Oncology (2013)

82 Background: Neoadjuvant chemoradiotherapy (CRT) is currently considered standard treatment in esophageal cancer patients who are eligible for surgical resection with curative intent. Objective was to evaluate the recurrence pattern after neoadjuvant CRT in patients with esophageal cancer. Methods: We analyzed the results and recurrence patterns from a single center (N=152) in a propensity score matched study between patients treated with neoadjuvant CRT (N=44) and surgery alone (44 from the 108),in the period 2002-2010. Patients treated with neoadjuvant (CROSS schedule) carboplatin/paclitaxel and 41.4 Gy radiotherapy, were compared with a historical cohort of patients with curative intended surgery alone. Surgery was performed through a transthoracic approach with 2-field lymphadenectomy. Results: After matching, the baseline characteristics were equally distributed between both groups (table 1). The response to CRT was 63%, with a pathological complete response of 26%. After a median follow-up of 23 months (7-74 months), lung was the most common site of distant recurrence (16%, N=7), followed by distant lymph nodes (11%, N=5) in the neoadjuvant CRT group, whereas skeletal metastases were the most common site of distant recurrence (18%, N=8), followed by skin or soft tissue (16%, N=7) in the surgical alone group. The estimated 3 and 5 year overall survival was 62% and 55% in the neoadjuvant CRT group, compared to 37% and 31% in the surgery group (Log-rank test: P=0.018). The estimated locoregional free recurrence survival (LRFS) after 3 and 5 years was 79% and 68% in the neoadjuvant CRT group, compared to 44% and 40% in the surgery alone group (Log-rank test: P=0.049). The estimated distant recurrence free survival (DRFS) was 63% and 54% after 3 and 5 years in the neoadjuvant CRT group, compared to 50% and 35% in the surgery alone group (Log-rank test: P=0.314). Conclusions: This neoadjuvant CRT regimen significantly improved oncological outcome compared to surgery alone. An important shift in recurrence pattern was observed from relatively high locoregional recurrences (LRFS) to relatively more distant recurrences (DRFS) in the CRT group compared to the surgery alone group.
The Cover
Authors: M. THERESE SOUTHGATE
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Men and octogenarians do well after surgery for abdominal aortic aneurysms
Journal: BMJ (1998)

No link exists between exposure to benzodiazepines in pregnancy and cleft palateConflicting evidence exists about whether first trimester exposure to benzodiazepines increases the risk of major malformations or oral cleft.In their metaanalysis of cohort trials Dolovich et al (p 839) found that fetal exposure to benzodiazepines was not associated with major malformations or oral cleft, but a smaller pooled analysis on the basis of data from casecontrol studies found a significantly increased risk for major malformations or oral cleft.Even if the "worst case scenario" is assumed, benzodiazepines do not seem to be major human teratogens.
Contact Lens Health Week — August 20–24, 2018
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

August 20-24, 2018, marks the fifth annual Contact Lens Health Week. In collaboration with partners from clinical, public health, industry, and regulatory sectors, CDC is promoting healthy contact lens wear and care practices to reduce the risk for eye infections among the approximately 45 million persons in the United States who wear contact lenses. Research after outbreaks of rare but serious eye infections in the United States has indicated that these infections occur most often in contact lens wearers who do not take proper care of their contact lenses, indicating a need to promote safer wear and care (1,2).
Should the risk of acquired immunodeficiency syndrome deter hepatitis B vaccination? A decision analysis
Authors: H. S. Sacks
Journal: JAMA (1984)

The current epidemic of acquired immunodeficiency syndrome (AIDS) and fear that its causative agent contaminates the currently available hepatitis B vaccine may have deterred vaccine use. We formulated a decision-analytic model that compares the risk of death from hepatitis B and AIDS in those vaccinated with the risk of death from hepatitis B alone in those who wait two years for a synthetic vaccine. For individuals with 5% annual risk of hepatitis B, the best current estimate is that vaccination now would save 25 lives per 100,000. The best current estimate of the rate of vaccine-induced AIDS is zero, and one can be 95% confident that the rate is less than eight per 100,000. The rate would have to be considerably higher before postponement of vaccination would be rational for those for whom vaccination has been recommended. (<i>JAMA</i>1984;252:3375-3377)
Pericardial Biopsy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal