tbuckley/cabot-search huggingface dataset:
1011. Growth Factor Receptors as Regulators of Hematopoiesis
Authors: Michael A. Weinreich, Ingrid Lintmaer, Linlin Wang, H. Denny Liggitt, Michael A. Harkey, C. Anthony Blau
Journal: Molecular Therapy (2006)

Nearly 15 years have elapsed since the U.S. Food and Drug Administration last approved a major new hematopoietic cytokine. Promiscuous binding to multiple receptors, or to receptors expressed by multiple tissues, reduces growth factor specificity and promotes side effects. Here we show that hematopoiesis can be differentially regulated using receptors rather than ligands. Conditional derivatives of both fibroblast growth factor receptor–1 (F36VFGFR1) and the thrombopoietin receptor (F36VMpl) induced a sustained expansion of mouse marrow cells ex vivo, and erythroid cells in vivo. Only F36VFGFR1 supported the ex vivo expansion of short-term repopulating hematopoietic stem cells (HSCs), the ex vivo survival of long-term repopulating HSCs, and the prolonged in vivo expansion of granulocytes, monocytes and platelets. Only F36VMpl induced a response sufficiently rapid to accelerate hematological recovery from radiation-induced myelosuppression. These results establish receptors as a new class of hematopoietic regulators possessing activities unobtainable with growth factors. Blau is named as an inventor on a patent owned by the University of Washington that encompasses this work.
Effect of tissue temperatures and blood flow on motor nerve conduction velocity
Authors: D. I. Abramson
Journal: JAMA (1966)

The existence of a relationship between peripheral nerve conduction velocity and ambient temperature is supported by considerable experimental evidence.<sup>1-5</sup>For example, Rosenberg and Sugimoto<sup>1</sup>exposed the sciatic nerve of frogs to a temperature range of 78.8 to 38.3 F (26 to 3.5 C) and noted that, on the average, conduction velocity decreased from 33 meters/sec to 6 meters/sec, the change occurring slowly above 53.6 F (12 C) and rapidly below this level. Gasser,<sup>2</sup>using the phrenic nerve of the dog, also showed that cooling this structure decreased its conduction velocity. Chatfield et al<sup>3</sup>subsequently performed a similar type of procedure on the tibial nerves of rats and hamsters and came to the same conclusion. Tasaki and Fujita,<sup>4</sup>studying the isolated single nerve fiber of the toad, found that the relationship between the ambient temperature and the logarithms of conduction time, spike duration, and chronaxie for
Differential Effects of Prenatal and Postnatal Nutritional Environment on β-Cell Mass Development and Turnover in Male and Female Rats
Authors: Aleksey V. Matveyenko, Inderroop Singh, Bo-Chul Shin, Senta Georgia, Sherin U. Devaskar
Journal: Endocrine Reviews (2010)

Fetal nutrient and growth restriction is associated with development of type 2 diabetes. Although the exact mechanisms responsible for this association remain debated, intrauterine and/or postnatal maldevelopment of β-cell mass has been proposed as a potential mechanism. To address this hypothesis, β-cell mass development and turnover was assessed in rats exposed to either intrauterine and/or postnatal caloric/growth restriction. In total, four groups of male and female Sprague Dawley rats (n = 69) were developed and studied: 1) control rats, i.e. control mothers rearing control pups; 2) intrauterine calorically and growth-restricted rats, i.e. 50% prenatal calorically restricted pups cross-fostered to control mothers; 3) postnatal calorically and growth-restricted rats, i.e. 50% calorically restricted mothers rearing pups born to control mothers; and 4) prenatal and postnatal calorically and growth restricted rats, i.e. 50% calorically restricted mothers rearing intrauterine 50% calorically restricted pups. Intrauterine growth restriction resulted in approximately 45% reduction of postnatal β-cell fractional area and mass characterized by reduced rate of β-cell replication and decreased evidence of neogenesis. In contrast, β-cell fractional area and weight-adjusted β-cell mass in postnatal growth restriction was approximately 30% higher than in control rats. Rats exposed to both intrauterine and postnatal caloric and growth restriction demonstrated approximately 80% decrease in β-cell mass, reduction in β-cell replication, and decreased evidence of neogenesis compared with control. Neither intrauterine nor postnatal caloric restriction significantly affected the rate of β-cell apoptosis. These data support the hypothesis that intrauterine maldevelopment of β-cell mass may predict the increased risk of type 2 diabetes in adult life.
Abstracts for the Society of Nuclear Medicine and Molecular Imaging, Greater New York and New England Chapters, 31st Annual Northeast Regional Scientific Meeting, Mystic CT, November 3–5, 2017
Journal: Clinical Nuclear Medicine (2018)

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ECG Limitations
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TOBIAS SMOLLETT (1721-1771) SCOTTISH NOVELIST
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detection of narcotic drugs, tranquilizers, amphetamines, and barbiturates in urine
Authors: V. P. Dole
Journal: JAMA (1966)

A method for detection in urine of narcotic drugs, quinine, barbiturates, amphetamines, and some tranquilizers appears to be applicable to a wide range of diagnostic problems and epidemiological studies. The drugs are first absorbed on ion-exchange paper and then eluted with a series of buffer-solvent systems. An aliquot of the solvent phase is concentrated and chromatographed. A series of detection sprays have been developed to provide both sensitive detection and confirmation of positive results.
Modest Obesity Reduction In Low-Income Kids
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence-Based Medicine
Authors: Janet M. Torpy
Journal: JAMA (2009)

Evidence-Based Medicine In the 1990s, evidence-based medicine emerged as a way to improve and evaluate patient care.It involves combining the best research evidence with the patient' s values to make decisions about medical care.Looking at all available medical studies and literature that pertain to an individual patient or a group of patients helps doctors to properly diagnose illnesses, to choose the best testing plan, and to select the best treatments and methods of disease prevention.Using evidence-based medicine techniques for large groups of patients with the same illness, doctors can develop practice guidelines for evaluation and treatment of particular conditions.In addition to improving treatment, such guidelines can help individual physicians and institutions measure their performance and identify areas for further study and improvement.The February 25, 2009, issue of JAMA includes an article about the importance of using evidencebased medicine to develop practice guidelines.This Patient Page is based on one published in the September 6, 2006, issue of JAMA.
THE QUALITY OF COMPRESSED AIR FOR SPRAYS AND INHALATIONS.
Authors: D. LICHTY
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Surgery
Authors: Claude E. Welch, Ronald A. Malt
Journal: New England Journal of Medicine (1979)

THIS article summarizes some of the important advances in gastroenterological surgery since the last report three years ago.Hiatus Hernia and Gastroesophageal RefluxThe presence of gastroesophageal reflux is more important to the patient than whether or not he has a sliding hiatus hernia. Except in unusual cases (such as short esophagus, Barrett's ulcer or stricture, and previous hiatal surgery) reflux may be corrected by restoration of an adequate length of abdominal esophagus. The three common repairs have been described by Nissen, Belsey and Hill; all attempt to achieve their goals using whatever tissue is available. . . .
Modern Physical Therapy Technique.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SECOND ANNUAL MEETING OF THE AMERICAN MEDICAL TEMPERANCE ASSOCIATION.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Synopsis of Surgery.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase III Trial Comparing a Defined Duration of Therapy Versus Continuous Therapy Followed by Second-Line Therapy in Advanced-Stage IIIB/IV Non–Small-Cell Lung Cancer
Authors: Mark A. Socinski, Michael J. Schell, Amy Peterman, Kamal Bakri, Steven Yates, Robert Gitten, Paul Unger, Joanna Lee, Ji-Hyun Lee, Maureen Tynan, Martha Moore, Merrill S. Kies
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To compare four cycles of therapy versus continuous therapy to determine the optimal duration of chemotherapy in advanced non–small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Stage IIIB/IV NSCLC patients were randomized to arm A (four cycles of carboplatin at an area under the curve of 6 and paclitaxel 200 mg/m 2 every 21 days) or arm B (continuous treatment with carboplatin/paclitaxel until progression). At progression, all patients on both arms were to receive second-line weekly paclitaxel at 80 mg/m 2 /wk. The primary end points were survival and quality of life (QOL). RESULTS: Two hundred thirty patients were randomized. Fifty-seven percent of arm A patients completed four courses of therapy. In the 116 arm B patients, the median number of cycles delivered was four (range, zero to 19 cycles). Forty-two percent received five or more cycles; 18% received eight or more cycles. Overall response rates were 22% and 24% for arms A and B, respectively (P = .80). Median survival time and 1-year survival rates were 6.6 months and 28% for arm A and 8.5 months and 34% for arm B, respectively (log-rank P = .63). Rates of hematologic and nonhematologic toxicity were similar between the two arms, except for neuropathy. The rate of grade 2 to 4 neuropathy increased from 19.9% (95% confidence interval [CI], 13.6% to 26.2%) at cycle 4 to 43% (95% CI, 28.6% to 57.4%) at cycle 8. There were no differences in QOL. Only 45% of patients received second-line therapy (42% in arm A v 47% in arm B, P = .42). CONCLUSION: This study shows no overall benefit in survival, response rates, or QOL to continuing treatment with carboplatin/paclitaxel beyond four cycles in advanced NSCLC.
Previously unrecognized diabetes mellitus in sexually impotent men
Authors: S. Deutsch
Journal: JAMA (1980)

Three-hour oral glucose tolerance tests (GTTs) were performed for 58 men with secondary impotence (SI), 63 with normal sexual function (NL), and 69 with premature ejaculation (PRE). All were apparently nondiabetic. Diagnoses of diabetes and impaired glucose tolerance were based on serum glucose levels during GTT as recently defined by the National Diabetes Data Group. Covariance analysis corrected for weight and age differences. Mean glucose levels in patients with SI were significantly higher at one and two hours after glucose ingestion than in the other groups. Seven patients with SI (12.1%) were found to have diabetes. The three groups did not differ notably in frequency of impaired glucose tolerance. Inorganic serum phosphate levels were lower for the SI group. The high frequency of diabetes in subjects with SI who have no diabetic symptoms (12.1%) suggests that localized neuropathy or penile ischemia may produce impotence in otherwise asymptomatic patients. (<i>JAMA</i>244:2430-2432, 1980)
Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development #
Authors: Kinji Asahina, Hidekazu Tsukamoto
Journal: Hepatology (2009)

We thank Dr. Ramadori and Dr. Mansuroglu for their comments on our recent publication1 reporting the classification of fetal liver mesenchymal cells into three populations based on the location and immunostaining: hepatic stellate cells (HSCs) in the liver parenchyma, perivascular mesenchymal cells around the veins, and submesothelial cells beneath the basal lamina near the liver surface. As they pointed out, we found that there are rare desmin-positive alpha smooth muscle actin (αSMA)–positive mesenchymal cells near the veins in the developing mouse liver. We assume that this minor population represents heterogeneity of fetal HSCs as previously reported in the human liver2 or a transitional cell type between HSCs and perivascular mesenchymal cells. It is also possible that this minor population may become the cells within the arteriole wall in the adult liver. A cell lineage analysis of this minor perivascular cell population is important, but this requires identification of new and definitive molecular markers. We identified activated leukocyte cell adhesion molecule (ALCAM) as a marker for submesothelial cells and mesothelial cells in the developing mouse liver. Unfortunately, fetal HSCs and perivascular mesenchymal cells do not express ALCAM and therefore cannot be separated with fluorescence activated cell sorting. We are looking for new distinct cell surface markers to achieve this goal. Using anti-ALCAM antibodies, we separated an ALCAMhigh population containing submesothelial cells and mesothelial cells.1 The cultured ALCAMhigh population rapidly acquired a myofibroblastic phenotype on a plastic dish; the expression of αSMA messenger RNA (mRNA) showed a nearly 400-fold increase already at day 1, and this was maintained on day 8. When the cells were cultured in collagen gel, αSMA mRNA was increased 25- and 157-fold on days 1 and 8, respectively; this suggests that the myofibroblastic conversion is delayed in collagen gel (unpublished data, 2009). We are currently examining gene expression of these cells upon retinol and palmitic acid treatment. Although we did not test ALCAM immunostaining on the cultured ALCAMhigh cells in collagen gel, quantitative reverse-transcription polymerase chain reaction revealed reduced mRNA expression in a collagen gel culture (unpublished data, 2009). Kinji Asahina Ph.D.*, Hidekazu Tsukamoto D.V.M., Ph.D.*, * Southern California Research Center for Alcoholic Liver and Pancreatic Disease and Cirrhosis, Department of Pathology Keck School of Medicine, University of Southern California, Los Angeles, CA.