tbuckley/cabot-search huggingface dataset:
Experimental study of biological effects of leads and aluminum following oral administration
Authors: G N Krasovskiĭ, L Y Vasukovich, O G Chariev
Journal: Environmental Health Perspectives (1979)

A wide spectrum of the biological effects of lead and aluminum ions is noted during short-term and long-term oral administration to laboratory animals.The general toxic and gonadotoxic effects of these metals during a short-term experiment appeared to be identical, and the correlation of these effects was preserved during chronic experiments.Lead (0.03 mg/I.) and aluminum (0.5 mg/I.)concentrations in water may be dangerous to the health of the population, and hygienic standards are recommended for inclusion in the standard for drinking water quality.
Abstract 2086: Targeting the MNK effector hnRNPA1 enhances the efficacy of BET inhibitors in cancer cells
Authors: Thao Pham, Sophie Stempel, Mario Shields, Christina Spaulding, Krishan Kumar, David Bentrem, Hidayatullah Munshi
Journal: Cancer Research (2019)

Abstract Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate gene expression and are involved in cancer pathogenesis. While a number of BET inhibitors are currently in preclinical development or in early phase clinical trials, BET inhibitors show limited single-agent activity. Thus, there is increasing interest in identifying combination regimens to enhance the efficacy of BET inhibitors. Since MNK kinases can enhance the efficacy of BET inhibitors in vitro and in vivo, in this report we evaluated whether targeting effectors downstream of MNK kinases can enhance the efficacy of BET inhibitors. We show that there is co-expression of the BET protein BRD4 and the MNK effector hnRNPA1 in human tumors. We show that hnRNPA1 knockdown can potentiate the effects of BET inhibitors, with enhanced apoptosis and suppression of proliferation and sphere-forming ability by cancer cells. We also show that the plant flavonoid Quercetin, which reduces hnRNPA1 protein levels in cancer cells, can enhance the efficacy of BET inhibitors. Co-treatment with BET inhibitors and Quercetin results in enhanced apoptosis, further suppression of proliferation, and decreased sphere-forming ability by cancer cells. Significantly, Quercetin synergizes with BET inhibitors at suppressing tumor growth in vivo. Together, these results demonstrate that targeting the MNK effector hnRNPA1 can enhance the efficacy of BET inhibitors, and we identify combination therapy with BET inhibitors and Quercetin for the treatment of cancer patients. Citation Format: Thao Pham, Sophie Stempel, Mario Shields, Christina Spaulding, Krishan Kumar, David Bentrem, Hidayatullah Munshi. Targeting the MNK effector hnRNPA1 enhances the efficacy of BET inhibitors in cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2086.
The outcome of re-treatment of relapsed hepatitis C virus infection after direct acting antiviral treatment failure in resource-limited settings
Authors: Gina Naguib, Tari George Michael, Yehia Elshazly, Maha Magdy Wahdan, Aya Mostafa, Ossama Ahmed, Hany Dabbous, Heba Aly, Mohamed Kamal Shaker, Magdi El-Serafy, Wahid Doss, Mahmoud Elmeteini, Manal Hamdy El-Sayed
Journal: Journal of Hepatology (2020)
Biocultural Perspectives on Women's Health
Journal: Environmental Health Perspectives (1997)

During the 1997 meeting of the American Association for the Advancement of Science, a session was devoted to biocultural perspectives on women's health in developing countries. The topics covered included female circumcision conducted as part of the traditional wedding ceremony of the Rendille people of Kenya and the deleterious effect of sociocultural factors such as acceptance of premarital sexual intercourse and early child-bearing on the health of adolescent girls in West Africa. A study in Bangladesh sought information on women's health during pregnancy and lactation. Using 19,000 paired questionnaires and urine samples from 493 women representing all reproductive states, pregnancy-related sickness (such as nausea and vomiting) was correlated to hormone levels, maternal age, and fetal loss. Preliminary results contradict a popular belief that incidence of pregnancy-related sickness is associated with a lowered risk of early fetal loss. Another study in Bangladesh revealed that previous research indicating that women in Bangladesh experience menopause eight years sooner than US women was inaccurate. The two-year earlier onset of menopause found in Bangladesh is likely caused by stress-related anovulation. A preliminary literature review has also shown that Bangladeshi women lack significant amounts of phytoestrogens in their diet. Improved knowledge of biocultural factors is sought as a prerequisite for improving medical treatment in developed and developing countries.
Metabolomic Profiling Identifies Mechanisms Regulating Hypoxia-Induced Drug Resistance in Multiple Myeloma
Authors: Patricia Maiso, Yosra Aljawai, Antonio Sacco, Susanne B Breitkopf, Ilyas Sahin, Salomon Manier, Yang Liu, John M Asara, Aldo M Roccaro, Irene M. Ghobrial
Journal: Blood (2012)
BRONCHIAL SPIROCHETOSIS
Authors: G GOUFAS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RPS Policy Promotion Grants
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer chemoprevention.
Authors: W K Hong, S M Lippman
Journal: Journal of Clinical Oncology (1994)

To review the most important recent advances in clinical trials and biologic studies within the growing field of chemoprevention.The most critical methods issue concerns the definitive end point of phase III trials, which is now cancer incidence. This end point usually needs thousands of subjects monitored for 5 to 10 or more years to determine efficacy. Biologic markers of potential intermediate end points are under intensive study and may one day replace cancer incidence. Validated intermediate end point biomarkers could greatly reduce phase III trial populations, durations, and costs.Randomized clinical trials over the last 5 years have produced significant activity in reversing oral, skin, colon, and cervical premalignancy; in preventing primary skin and stomach cancer; and in preventing second primary tumors associated with head and neck and lung cancer. These clinical advances have been paralleled at the basic science level by elegant molecular studies of premalignant carcinogenesis and of chemopreventive agents' mechanisms of action. One major laboratory advance is the discovery of nuclear retinoic acid receptors and strong evidence of their roles both in carcinogenic progression and in its response to retinoids.Chemoprevention has matured greatly in recent years with the significant reversal or suppression of premalignancy by chemopreventive agents in several sites. The future of chemoprevention will be determined largely by several ongoing phase III trials, including trials of retinoids, beta-carotene, and alpha-tocopherol in the aerodigestive tract, of tamoxifen and fenretinide in the breast, and of finasteride in the prostate.
Legal Advice
Authors: Joseph Zarconi
Journal: Annals of Internal Medicine (2008)

On Being a Doctor21 October 2008Legal AdviceJoseph Zarconi, MDJoseph Zarconi, MDFrom Summa Health System and Northeastern Ohio Universities College of Medicine, Akron, OH 44304.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-8-200810210-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I knew after the first few sentences of our conversation that I would need to schedule her follow-up appointments for longer time slots than the usual 15 minutes. I knew that she would put me behind schedule in this first appointment. She was going to disrupt the efficiency of my office on this day and probably for a long time to come. Her problem wasn't simple.She had a primary kidney disease that led to the nephrotic syndrome, a condition that results from the spillage of large amounts of protein molecules from the blood as it traverses the kidney's filtering ... Author, Article, and Disclosure InformationAffiliations: From Summa Health System and Northeastern Ohio Universities College of Medicine, Akron, OH 44304.Corresponding Author: Joseph Zarconi, MD, Summa Health System, 55 Arch Street, Suite G4, Akron, OH 44304; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Treachery of Images: How René Magritte Informs Medical Education 21 October 2008Volume 149, Issue 8Page: 589-590KeywordsEmotionsIntensive care unitsKidneysLungsNursesPneumoniaProteinsRenal diseasesResuscitationThorax ePublished: 21 October 2008 Issue Published: 21 October 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Commentaire de travail de A. Eickhoff et al., pp. 637
Journal: Endoscopy (2007)

See also: Prospective nonrandomized comparison of two modes of argon beamer (APC) tumor desobstruction: effectiveness of the new pulsed APC versus forced APCEndoscopy 2007; 39(07): 637-642DOI: 10.1055/s-2007-966571
Hurley Hospital in Flint
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE WATER WE DRINK.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Panic
Authors: Elio Notini
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACUTE METABOLIC INFLUENCES ON THE NATRIURETIC PEPTIDE SYSTEM IN HUMANS
Authors: Pankaj Arora, Connie Wu, Tariq Hamid, Garima Arora, Dongjian Hu, Ibrahim J. Domain, Emmanuel Buys, Donald Bloch, Sumanth Prabhu, Kenneth D. Bloch, Christopher Newton-Cheh, Thomas Wang
Journal: Journal of the American College of Cardiology (2015)
Pulmonary Cryptococcosis: Must All Receive Amphotericin B?
Authors: Vernon N. Houk
Journal: Annals of Internal Medicine (1965)

s1 May 1965Pulmonary Cryptococcosis: Must All Receive Amphotericin B?Vernon N. Houk, Kenneth M. Moser, M.D., F.A.C.P.Vernon N. HoukSearch for more papers by this author, Kenneth M. Moser, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1090_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPulmonary cryptococcosis, once considered a rarity, is now being diagnosed with increasing frequency. The diagnosis is seldom suspected clinically pre-operatively, no doubt due to the lack of experience and lack of availability of diagnostic studies available in certain other granulomatous diseases. Surgical resection of isolated pulmonary cryptococcosis is the treatment of choice. Many authors emphasize the necessity for treating with amphotericin B before dissemination occurs, even after surgical resection of the lesion.Three cases of primary pulmonary cryptococcosis are reported. One man without other disease, who remained asymptomatic and well, had changing lesions in both lungs over a 10-year period.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1090-1090KeywordsAmphotericinCryptococcosisLesionsLungsSurgical resection Issue Published: 1 May 1965 PDF DownloadLoading ...
The factor of disease in the world food problems
Authors: H. Pollack
Journal: JAMA (1970)

The paramount world health problems appear to be those of nutrition and infectious disease and their interrelationships in a self-reinforcing cause-effect cycle. Three of the major disease entities, dysentery, malaria, and tuberculosis of the respiratory tract are evaluated in terms of caloric energy losses resulting from both increased metabolism in disease and lost productivity. In terms of annual caloric cost of disease, respiratory tuberculosis is clearly the most wasteful disease entity per case; while malaria, because of its high incidence levels, remains the more significant world health problem. Using 1965 disease incidence data even a conservatively based first approximation indicates that the value of present nutritional losses occasioned by a population's disease burden is not trivial. There is potential significance of such calculations to national development planners.
The Transitions from Ancient Egyptian to Greek Medicine.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15388: Persistent Pulmonary Hypertension After Transcatheter Aortic Valve Implantation: Impact on Mortality
Authors: Maria Drakopoulou, Konstantinos Stathogiannis, Konstantinos Toutouzas, George Latsios, Andreas Synetos, Constantina Aggeli, Odysseas Kaitozis, George Trantalis, Nikos Anousakis, Dimitrios Tousoulis
Journal: Circulation (2015)

Objective: Severe aortic stenosis leads to increased pulmonary arterial systolic pressure. A controversy still remains regarding the impact of persistent pulmonary hypertension (PHT) on prognosis of patients undergoing transcatheter aortic valve implantation (TAVI). We sought to investigate the impact of persistent PHT on 2-year all-cause mortality of patients with severe aortic stenosis following TAVI. Methods: Patients with severe and symptomatic aortic stenosis (effective orifice area [EOA]≤1 cm 2 ) who were scheduled for TAVI with a self-expanding valve at our institution were prospectively enrolled. Prospectively collected echocardiographic data before and after TAVI were retrospectively analyzed in all patients. Pulmonary artery systolic pressure was estimated as the sum of the right ventricular to the right atrial gradient during systole and the right atrial pressure. PHT following TAVI was classified as absent if &lt;35 mmHg and persistent if ≥35 mmHg. Primary clinical end-point was 2-year all-cause mortality defined according to the criteria proposed by the Valve Academic Research Consortium-2. Results: Hundred and forty patients (mean age: 82±9 years) were included in the study. The primary clinical end point occurred in 17 patients (12%) during a median follow-up period of 2 years. Mean pulmonary artery systolic pressure was reduced in all patients following TAVI (45±9 versus 41±6 mmHg, p&lt;0.01). Mortality rate was higher in patients with persistent PHT compared to patients with normal pulmonary artery systolic pressure following TAVI (26% versus 14 %, p&lt;0.01). Patients that reached the primary clinical end point had a higher post procedural mean systolic pulmonary pressure (43±9 versus 39±6 mmHg, p=0.02). In multivariate regression analysis, persistence of PHT (OR: 2.51, 95% CI: 1.109-7.224, p=0.01) was an independent predictor of long-term mortality. Conclusions: The persistence of pulmonary hypertension after TAVI is associated with long term mortality. Identifying the population that will clearly benefit from TAVI is still need to be validated by larger trials.
Erratum
Journal: JNCI Journal of the National Cancer Institute (1994)

Editorial by M. H. Gail, J. Benichou [J Natl Cancer Inst 86:573–575, 1994 (Issue 8)]. The title of the editorial by Gail and Benichou was mistakenly given as “Epidemiology and Biostatistics Program of the National Cancer Institute.” The correct title is “Validation Studies on a Model for Breast Cancer Risk.” The Journal regrets the error.
Clouds above the gene theory
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal