tbuckley/cabot-search huggingface dataset:
Tailored neoadjuvant epirubicin and cyclophosphamide (EC) and nanoparticle albumin bound (<i>nab</i>)-paclitaxel for newly diagnosed breast cancer (BC).
Authors: Mustafa Khasraw, Violet Rudo Mukaro, Linda West, Conrad Brandt, Anne Maree Woollett, Michelle Edwards, Robert Spokes, Gregory Mitchell, Kimberley Prince, Theresa M. Hayes, Ian M. Collins, Alexander David Guminski, Sally E. Baron-Hay, Inger Helen Olesen, Jacinta Bryan, Susan Bowles, Shu Fen Wong, David M. Ashley, Sujata Patil
Journal: Journal of Clinical Oncology (2015)

e12025 Background: We evaluated tailored neoadjuvant chemotherapy (NAC) with sequential EC followed by nab-Paclitaxel. OncotypeDX assay was used to select women with Hormone Receptor (HR) + early BC. Methods: Between 4/2013 and 1/2015, patients with stage II (T > 2cm) or III BC received Epirubicin 90mg/m2 and Cyclophosphamide 600mg/m2 Q3 weeks x 4, followed by nab-Paclitaxel (125mg/m2 IV days 1, 8, 15 Q4 weeks) for 12 weeks. Trastuzumab Q3 weeks was added to nab-paclitaxel in HER2+ patients. The primary cohort consisting of forty women (15 HER2+, 15 triple negative and 10 patients with OncotypeDX assay Recurrence Score ≥ 25) were evaluated for rate of pathologic Complete Response (pCR). Eleven women with HR+ BC and RS < 25 were treated in a separate exploratory cohort of neoadjuvant hormonal treatment. The primary endpoint was rate of pCR in the breast. Response Rate (RR) for the null hypothesis was set at 30% and for the alternative (worthy of further study) at 50% (CI 95%) i.e., if 17 or more patients achieve pCR at the end of the study, the regimen will be deemed worthy of further study. Secondary endpoints include pCR in breast and lymph nodes, rate of breast conservation, toxicity (measured by CTCAE v.4), PFS and a number of translational endpoints using pre- and post-chemotherapy MRIs and tissue analysis. Clinicaltrials.gov #: NCT01830244. Results: Median age was 50 years (34-76) in the primary cohort (n = 40). Clinical stage at diagnosis is outlined in Table 1. Clinical lymph node involvement at diagnosis was confirmed with needle biopsy in 20 out of the 27 patients with N1-3 stage BC. An independent data safety board regularly reviewed study conduct and the chemotherapy regimen was well tolerated with < 10% rate of grade 3 - 4 adverse events. Conclusions: Selection of BC patients for NAC using our NEONAB study approach including use of Oncotype DX in the neoadjuvant setting was feasible with acceptable toxicities. The clinical endpoint including PCR rate in the breast and lymph nodes, toxicity, radiologic response rates and rates of breast conservation will be reported at the annual meeting. Clinical trial information: NCT01830244. Characteristic No % T stage T2 26 67.5 T3 10 25 T4 3 7.5 cN stage N0 13 32.5 N1 16 40 N2 9 22.5 N3 2 5
Abstract 4500: Mechanisms of tumor-associated myeloid cells in modulating host immune microenvironment and metastatic progression
Authors: Hiroki Ishii, Christine Hollander, Tim Greten, Li Yang
Journal: Cancer Research (2019)

Abstract The immune checkpoint inhibitor blockade takes advantage of the specific receptor-ligand interactions between immune and tumor cells. However, the immunosuppressive microenvironment has been largely ignored, which likely contribute to low efficacy and resistance in immune therapies. Our studies demonstrate that TGF-β signaling in tumor-associated myeloid cells isessential in systemic immune suppression and metastatic progression. Using mouse models of breast cancer metastasis, we further uncover that miR130a and 145 are critical in regulating TGF-β signaling in myeloid cells. miR130a and 145 are down-regulated in these myeloid cells, leading to increased TGF-β RII. Ectopic expression of miR-130a and miR-145 in the myeloid cells decrease tumor metastasis. This is mediated through a downregulation of type 2 cytokines in myeloid cells and an increase in IFNgamma-producing cytotoxic CD8 T lymphocytes. Lastly, miR-130a and miR-145 mimics improve systemic anti-tumor immunity and inhibit metastasis in preclinical mouse models. Another important mechanism in myeloid-mediated immune suppression involves a decreased expression of Lamin A/C, nuclear lamina proteins that prominently interact with heterochromatin. Lamin A/C knockout in myeloid cells leads to H3K4me3-mediated upregulation of Gfi1 and C/EBPϵ,critical transcription factors responsible for granulocytic lineage differentiation. In addition, loss of Lamin A/C attenuates antigen-presentation and compromises host anti-tumor immunity. These mechanistic understandings provide options to reprogram tumor-associated myeloid cells by altering the cytokine milieu and metastatic microenvironment, thus enhancing host antitumor immunity. Citation Format: Hiroki Ishii, Christine Hollander, Tim Greten, Li Yang. Mechanisms of tumor-associated myeloid cells in modulating host immune microenvironment and metastatic progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4500.
USAN assigned to radioactive pharmaceutical
Journal: JAMA (1976)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculosis
Authors: Donald S. King
Journal: New England Journal of Medicine (1955)

ResectionTo proceed to a brief discussion of the now popular operation of resection, particularly segmental resection, one should speak first of the papers of Chamberlain et al.57 and O'Brien et al.58 presented at the meeting of the American Association for Thoracic Surgery in March, 1953. Of Chamberlain's 300 consecutive patients followed for one to five years 93.7 per cent were reported as living and well, 3.3 per cent living with disease, and 3 per cent dead. One must, of course, realize that these were minimal lesions with more than adequate drug coverage. The paper of O'Brien et al. is . . .
Contents
Authors: Namrata Sharma, Jacob Chacko, Thirumurthy Velpandian, Jeewan Titiyal, Rajesh Sinha, Gita Satpathy, Radhika Tandon, Rasik Vajpayee, Amira Stylianides, Mark Jones, Rosalind Stewart, Conor Murphy, Nicola Goodson, Stephen Kaye, Daniel Repp, David Hodge, Keith Baratz, Jay Mclaren, Sanjay Patel, Weiyun Shi, Min Chen, Lixin Xie, Mingna Liu, Hua Gao, Ting Wang, Xianggen Wu, Jing Zhao, Camiel Boon, Linda Visser, Jan Keunen, Arthur Bergen, Judith Booij, Frans Riemslag, Ralph Florijn, Mary Van Schooneveld
Journal: Ophthalmology (2013)
Guanylyl Cyclase-Linked Receptors
Authors: P. Yuen
Journal: Annual Review of Neuroscience (1992)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
ANNUAL CONGRESS ON MEDICAL EDUCATION AND LICENSURE
Authors: Ray Lyman Wilbur
Journal: JAMA (1941)

<h3>COUNCIL ON MEDICAL EDUCATION AND HOSPITALS</h3> February 17—Morning <h3>Report of the Council on Medical Education and Hospitals</h3> Dr. Ray Lyman Wilbur, Stanford University, Calif.: This article appeared in full inThe Journal, February 22, page 661. <h3>The Contribution of Liberal Education to Professional Studies</h3> Oliver C. Carmichael, LL.D., Nashville, Tenn.: This article appeared in full inThe Journal, March 22, page 1325. <h3>Universities and the People's Health</h3> Dr. Raymond B. Allen, Chicago: University medical establishments have largely assumed the responsibility for the fundamental education and training of the health personnel of the country. Colleges of medicine, dentistry, pharmacy and veterinary medicine and schools of public health have developed as integral parts of university systems. These colleges have to a large degree developed independently with varying degrees of coordination among them. The increasing interdependence of these disciplines is generally recognized, and steps are being taken to implement the need for more
THE INFLUENCE OF INTESTINAL BACTERIA ON THE PROPERTIES OF THE BLOOD SERUM.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytogenetic Markers of Susceptibility: Influence of Polymorphic Carcinogen-Metabolizing Enzymes
Authors: Hannu Norppa
Journal: Environmental Health Perspectives (1997)

Polymorphisms of xenobiotic-metabolizing enzymes, responsible for individual differences in metabolic activation and detoxification reactions, may profoundly modulate the effects of chemical carcinogens.In the case of genotoxic carcinogens, differences in biological effects due to genetic polymorphisms can be evaluated by cytogenetic methods such as the analysis of chromosomal aberrations (CAs), sister chromatid exchanges (SCEs), micronuclei (MN), and changes in chromosome number.These techniques can be applied to any exposure known to induce such alterations, without additional method development for each exposing agent.The influence of polymorphic genes on the cytogenetic effects of a carcinogen can quickly be tested in vitro using metabolically competent cells collected from donors representing different genotypes or phenotypes.For instance, erythrocytes from individuals positive for glutathione S-transferase Ti (GST1I) express GSTT1, whereas GSTT1-null donors, having a homozygous deletion of the GSTT1 gene, completely lack this detoxification enzyme.This deficiency results in highly increased sensitivity to SCE induction in whole-blood lymphocyte cultures by 1,2:3,4-diepoxybutane, a reactive metabolite of 1,3-butadiene.The same cytogenetic techniques can also be applied as effect biomarkers in studies of human populations exposed to genotoxic carcinogens.For example, elevated rates of chromosome damage have been detected among smokers lacking glutathione S-transferase Ml (GSTM1-null genotype), and the baseline level of SCEs seems to be increased in GSTT1-null individuals.Information obtained from cytogenetic studies of genetic polymorphisms can be used, for example, to recognize the genotoxically relevant substrates of the polymorphic enzymes, to identify genotypes that are susceptible to these genotoxins, to improve in vitro genotoxicity tests utilizing human cells, to increase the sensitivity of cytogenetic endpoints as biomarkers of genotoxic effects in humans, and to direct mechanistic studies and cancer epidemiology.
The US medical occupation of Japan and history of the Japanese-language edition of JAMA
Authors: S. Nishimura
Journal: JAMA (1995)

Beginning with the Allied Occupation in August 1945, US General Douglas MacArthur came to possess greater authority than Hirohito, Emperor of Japan. Similarly, in the field of medicine, Crawford F. Sams (Figure 1), Colonel of the Medical Corps of the US Army, had greater power than the Minister of Welfare of the Japanese government. Born in East St Louis, Ill, in 1902, Sams was the son of a lawyer who died when Sams was an adolescent. He attended Washington University Medical School in St Louis, Mo, and graduated fourth in his class while working at night for the St Louis office of the Great Northern Railroad.<sup>1</sup>During the Second World War, Sams served in North Africa, Europe, and Washington. Prior to the end of the Pacific War, MacArthur recruited Sams to assume the post of Chief, Public Health and Welfare Section (PHW), Supreme Commander for the Allied Powers (SCAP)
Editorial Board
Authors: Stavroula Kousta, Katja Brose, Rolf Van Der Sanden, Patrick Scheffmann, Ria Otten, R Adolphs, R Baillargeon, N Chater, P Dayan, S Dehaene, D Dennett, Y Dudai, A Engel, M Farah, A Friederici, O Hikosaka, R Jackendoff, P Johnson-Laird, N Kanwisher, M Kutas, N Logothetis, J Mcclelland, E Miller, R Poldrack, M Raichle, T Robbins, A Wagner, V Walsh, Clare Kelly, Bharat Biswal, R Craddock, F Xavier
Journal: Trends in Cognitive Sciences (2012)
Correction: Bevacizumab plus Fotemustine as First-line Treatment in Metastatic Melanoma Patients: Clinical Activity and Modulation of Angiogenesis and Lymphangiogenesis Factors
Journal: Clinical Cancer Research (2011)

In this article (Clin Cancer Res 2010;16:5862–72), which was published in the December 1, 2010 issue of Clinical Cancer Research (1), an affiliation for Prof. Mario R. Sertoli was missing. The correct affiliations for Prof. Sertoli are Department of Medical Oncology, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy and Department of Oncology, Biology, and Genetics, University of Genova, Genova, Italy.
Consensus conference. Magnetic resonance imaging
Journal: JAMA (1988)

Magnetic resonance imaging (MRI) is a new and innovative technique that affords anatomic images in multiple planes and that may provide information about tissue characterization. The first magnetic resonance image was published in 1973 by Paul Lauterbur, PhD. Since that time, major technological advances, together with increasing clinical and investigative interests in the method, have been accompanied by the development of equipment that is now clinically applicable to man, with potentially great benefits in assessing pathophysiological states. The magnetic resonance images are obtained by placing the patient or the area of interest within a powerful, highly uniform, static magnetic field. Magnetized protons (hydrogen nuclei) within the patient align like small magnets in this field. Radiofrequency pulses are then used to create an oscillating magnetic field perpendicular to the main field from which the nuclei absorb energy and move out of alignment with the static field in a state of excitation.
Potential Dangers of Radiation, Steroids Examined
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma
Authors: Yuka Aoki, Masanori Nojima, Hiromu Suzuki, Hiroshi Yasui, Reo Maruyama, Eiichiro Yamamoto, Masami Ashida, Mitsuhiro Itagaki, Hideki Asaoku, Hiroshi Ikeda, Toshiaki Hayashi, Kohzoh Imai, Mitsuru Mori, Takashi Tokino, Tadao Ishida, Minoru Toyota, Yasuhisa Shinomura
Journal: Genome Medicine (2013)
Iron &amp; disease
Authors: Clara Camaschella
Journal: HemaSphere (2018)

San Raffaele Scientific Institute, Milan, Italy This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Association News
Authors: Archer O'Reilly
Journal: JAMA (1925)

<h3>THE DALLAS SESSION</h3> Papers for Section on Orthopedic Surgery Any Fellow of the American Medical Association who wishes to present a paper before the Section on Orthopedic Surgery at the annual meeting is requested to communicate with the secretary of the section as soon as possible. All requests for place on the program must be accompanied by an abstract of the paper. Requests for place on the program are acted on by the Executive Committee. <h3>Conference on Negro Health Work.</h3> —A conference was held at the office of the Surgeon General, U. S. Public Health Service, October 21, to further health work among negroes. Among the delegates to the conference were Dr. Helen A. Moore, American Child Health Association; Franklin O. Nichols, National Health Council and the American Social Hygiene Association; William B. Matthews, National Tuberculosis Association, and R. Maurice Moss of the National Urban League. "More National Negro Health
Evaluating psychotherapy
Authors: P London, G L Klerman
Journal: American Journal of Psychiatry (1982)

The authors analyze the possible need for a standing national group to evaluate the efficacy and safety of the psychotherapies. The current need is for a body whose function is more scientifically evaluative and less regulatory than the Food and Drug Administration because available psychotherapies are less specific in their beneficial effects and less dangerous than are drugs and because the practice of psychotherapy cannot be restricted entirely to the health professions. Even so, the authors believe the main criteria for discerning the boundaries between research and established practice are in principle at least as clear for psychotherapy as for other health interventions.
Glucocorticoid Use and Risks of Ocular Hypertension and Glaucoma
Authors: Nicholas Macris
Journal: JAMA (1997)

<h3>To the Editor.</h3> —I am concerned that the study on glucocorticoid use and risk of ocular hypertension or open-angle glaucoma by Dr Garbe and colleagues<sup>1</sup>contains some serious flaws. First, the study examined the National Health Service database containing prescription drugs, diagnoses, and referrals for medical services rather than patient-specific information. Second, the inhaled glucocorticoid doses that caused an increased risk of glaucoma were very large. I calculated that the patients in this study would have had to use a minimum of 38 inhalations daily of a standard beclomethasone dipropionate preparation available in the United States; this far exceeds the recommended dose for this drug. Third, the patient population was aged 66 years or older and, as noted in the study, at risk for ocular hypertension. Fourth, there was no clear-cut definition of asthma in this population, and there were no pulmonary function studies performed that demonstrated reversibility
Allergische Diathese und allergische Erkrankungen
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolic studies in unaffected co-twins of non-insulin-dependent diabetics
Authors: D. Pyke
Journal: BMJ (1981)

Forty-eight out of 53 non-insulin-dependent diabetic identical twin pairs were concordant for diabetes.In the five discordant pairs the diabetic twin had only recently been diagnosed.Oral glucose tolerance tests were carried out on the unaffected twins of the five pairs and on matched controls.Fasting concentrations of blood glucose (5 5+0 6 v 3-7±0 3 mmol/l; 99 1+10 8 v 66 6±5 4 mg/100 ml), haemoglobin A1 (mean 91%, range 8-8-9-2% v mean 7 9%, range 74-8 4%), lactate, alanine, and glycerol (0 090±0 017 v 01045±0 008 mmol/l); and the lactate: pyruvate ratio were significantly higher in the