tbuckley/cabot-search huggingface dataset:
Disseminated Cryptococcosis
Authors: Arthur J. Sakowitz
Journal: JAMA (1976)

INFECTIONS from bacterial, viral, fungal, or parasitic organisms are quite common in the immunosuppressed patient, and the physician is often faced with the problem of obtaining a diagnosis in a seriously ill patient so that appropriate therapy may be started without delay. We report the case of a patient in whom severe respiratory distress developed four months after starting prednisolone therapy for a complication of cataract surgery. A diagnosis of disseminated cryptococcal infection was established by flexible fiberoptic bronchoscopy with transbronchial forceps lung biopsy. <h3>Report of a Case</h3> A 67-year-old man was admitted to Valley Hospital for the second time on Aug 13, 1975, complaining of increasing shortness of breath, fever, nonproductive cough, and a persistent headache of one week's duration. In April 1975, he had undergone cataract surgery without complication, but in May 1975, a keratitis developed in the operated eye, and prednisolone treatment was begun. During the summer,
Changes of plasma hemostatic markers during percutaneous transluminal coronary angioplasty in patients with chronic coronary artery disease
Authors: Yasuhiro Saito, Hideo Wada, Miho Yamamuro, Akiko Inoue, Minori Shimura, Kazuyo Hiyoyama, Esteban C. Gabazza, Naoki Isaka, Hiroshi Shiku, Hiroyuki Takeya, Koji Suzuki, Kousuke Kumeda, Hisao Kato, Takeshi Nakano
Journal: American Journal of Hematology (1999)
Adverse Reactions
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FTY720 Increases CD74 Expression and Sensitizes Mantle Cell Lymphoma Cells to Milatuzumab-Mediated Cell Death
Authors: Lapo Alinari, Emilia Mahoney, John T. Patton, Xiaoli Zhang, Lenguyen Huynh, Christian Tyler Earl, Rajeswaran Mani, Yicheng Mao, Bo Yu, William H. Towns, Ching-Shih Chen, David M. Goldenberg, Kristie A. Blum, John C. Byrd, Natarajan Muthusamy, Mette Ibba, Robert A. Baiocchi
Journal: Blood (2011)
AUSTRIA
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Philadelphia Clinical Convention
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mammography in medical practice. A rational approach
Authors: M. Moskowitz
Journal: JAMA (1978)

REDUCED-DOSE mammography is an important adjunctive clinical tool for detecting and diagnosing small breast cancers. Mammography, aggressively used, will increase the detection of minimal breast cancers substantially. On the other hand, improperly used mammography may add unnecessarily to the patient's body burden of radiation and delay diagnosis of palpable masses. How can we avoid adding unnecessarily to the patient's body burden of radiation? Basically, this can be accomplished by (1) controlling the radiation dose and (2) selecting appropriate patients for mammographic examination. Today the average annual dose absorbed in the midbreast for two-view mammography can be reduced to 1 rad or less. At this level, lifetime annual mammography of a 35-year-old woman could possibly increase her risk of cancer from an expected spontaneous risk of 8% to a total risk of 8.3%. This risk estimate is based on extrapolation from high-dose data,<sup>1,2</sup>and there is a distinct statistical possibility
Ethnic differences in viral dominance patterns in patients with hepatitis B virus and hepatitis C virus dual infection
Authors: Long H. Nguyen, Mindie Nguyen
Journal: Hepatology (2012)

We appreciate Ronkenback et al.'s interest in our study. 1 The aim of the study was to further characterize hepatitis B virus/hepatitis C virus (HBV-HCV) dual infection, including viral dominance pattern, which is one of the most important topics in the study of HBV-HCV dual-infected patients. In addition to examining the clinical characteristics of HBV-HCV dual-infected cases, in comparison with HBV monoinfected controls, an analysis of viral dominance was suitably part of our main aims, even if it did not require the comparison of HBV-HCV cases and HBV monoinfected controls. The major findings and primary conclusions of the study are that HBV-HCV dual-infected and HBV monoinfected patients generally had similar clinical characteristics, Asian ethnicity is a major independent predictor of HBV-dominant disease, and HCV dominance with undetectable HBV DNA is more common in non-Asians, all of which were within the scope of our major aims. Long H. Nguyen B.A.*, Mindie Nguyen M.D., M.A.S.*, * Stanford University School of Medicine Stanford, CA
Onychotillomania
Authors: G.B. Colver
Journal: British Journal of Dermatology (1987)

Journal Article Onychotillomania Get access G.B. Colver G.B. Colver University Department of Dermatology, Edinburgh Royal Infirmary, Edinburgh EH39YW, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 3, 1 September 1987, Pages 397–399, https://doi.org/10.1111/j.1365-2133.1987.tb04150.x Published: 01 September 1987
Abstract 3464: CBAP: A novel rheostat molecule for regulation of TSC GAP activity and mTORC1 signaling in cancer cells
Authors: Jong-Young J. Yen, Yun-Jung Chiang, Wei-Ting Liao, Shih-Hao Wang, Hsin-Fang Yang-Yen
Journal: Cancer Research (2019)

Abstract The PI3K-mTOR signaling pathway is one of the most frequently dysregulated signaling cascades in cancer. Understanding the molecular wiring of the PI3K-mTOR signaling network and its activation in cancer will improve our understanding of their contribution to cancer pathology and provide novel therapeutic strategies by targeting this network. Our previous works demonstrated that Common receptor Beta chain Associated Protein (CBAP) is required for Jurkat cell leukemogenesis and regulates Akt-dependent TSC2 phosphorylation and lysosomal dissociation of TSC complexes, and in turn enhances mTORC1 signalling and expression of c-MYC and HIF-1a in Jurkat T-ALL leukemic cells. In this report, we tackle the question how TSC/Rheb/mTORC1 pathway is regulated by CBAP via cell-based functional assay, immunoprecipitation and in vitro GTPase assay. Our data revealed that CBAP interacted with TSC2 via tuberin-binding domain and could compete for TSC2 binding with TSC1 and suppressed the GTPase activation activity of TSC1/2 complexes. Akt could also associate with TSC2 complexes and CBAP in both Jurkat and CBAP-knockout Jurkat cells, except that TSC1 could be detected within the complexes only in the absence of CBAP. Moreover, the Rheb-GAP activity of this Akt-associated TSC2 complexes was sensitive to the presence of CBAP and TSC1/2 GAP activity was strongly suppressed by recombinant CBAP proteins in the in vitro reconstituted assay. Finally, a peptide domain of CBAP interacting with TSC2 was mapped and disruption of CBAP-TSC2 interaction by overexpressing this peptide inhibits the Akt/Rheb signal axis and suppresses leukemia cell growth. In summary, our data revealed an important role of the interaction between CBAP and TSC2 proteins in promoting Rheb/mTORC1 signaling activity, and suggested a crucial role of overexpression of CBAP protein in tumor cell proliferation. Citation Format: Jong-Young J. Yen, Yun-Jung Chiang, Wei-Ting Liao, Shih-Hao Wang, Hsin-Fang Yang-Yen. CBAP: A novel rheostat molecule for regulation of TSC GAP activity and mTORC1 signaling in cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3464.
Screening for hyperlipidemia in childhood
Authors: H. P. Chase
Journal: JAMA (1974)

Victims of early heart attacks were found to have elevated levels of serum cholesterol or triglycerides or both in 38 of 58 cases (66%). Blood lipid levels were determined in 179 offspring of 71 probands and were elevated in 52 (29%). It is recommended that all children of early heart attack victims be screened for hyperlipidemia. (<i>JAMA</i>230:1535-1537, 1974)
Abstract 1111: Embryoinc Stem Cell Derived Cardiovascular Progenitor Cells Improve Function More Than Hemangioblasts in a Mouse Model of Myocardial Infarction
Authors: Eric Adler, Vincient Chen, Anne Bystrup, Wilson Young, Steve Giovannone, Steve Kattman, Zahi Fayad, Gordon Keller
Journal: Circulation (2007)

BACKGROUND: Intramyocardial transplantation of stem cells improves left ventricular ejection fraction (EF) in animal studies and preliminary clinical trials. The mechanism may involve either replacement of myocytes or improved vascular supply to existing myocytes. We recently identified an Embyronic Stem cell derived cardiovascular progenitor cell (ES-CPC) that is the common precursor of cardiomyocyte and vascular cell lineages. To determine whether myocyte transplantation improves myocardial function more than angiogenesis alone does, we compared the effect of ES-CPCs to hemangioblasts (vascular/hematopoetic progenitor cells) on EF in a mouse model of myocardial infarction. METHODS: ES-CPC and hemangioblasts were isolated from a doxycycline-responsive, Notch-inducible ES cell line containing Notch 4 cDNA under the control of a tetracycline-inducible promoter. Notch induction of mesoderm-derived ES cells resulted in a CPC phenotype, whereas non-induced cells developed into hemangioblasts. Mice underwent transplantation of 500,000 ES-CPC (n=20), hemangioblasts (n=16), or an equal volume of serum-free media (n=12) 30 minutes after surgically-induced myocardial infarction. All cell lines constitutively expressed green fluorescent protein (GFP). EF was assessed two weeks post-transplantation using 9.4 Tesla MRI. Mice were then euthanized and frozen heart sections were examined using fluorescent microscopy. RESULTS: The mean EF was 59Â ± 15, 46Â ± 17, and 39Â ± 13% in the ES-CPC, hemangioblast, and control groups, respectively (p&lt;0.05 for the differences among all 3 groups; ANOVA). GFP + cells were detected in frozen sections of both the ES-CPC and hemangioblast groups. GFP + cells in ES-CPC treated hearts expressed markers associated with both cardiomyocyte and vascular phenotypes, whereas the GFP + cells in the hemangioblast group expressed markers associated with vascular phenotypes. CONCLUSIONS: Both hemangioblast and ES-CPC transplantation improves EF in a mouse model of myocardial infarction, but ES-CPC transplantation was more effective. This suggests that enhancement of myocardial function by transplantation of both cardiomyocyte and vascular phenotypes exceeds that with vascular phenotypes alone.
Neurology in Podiatry.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Appendicitis.
Authors: Robert T. Morris
Journal: JAMA (1898)

New York City, March 1, 1898. <h3>To the Editor:</h3> —I will undertake to refute the arguments of any correspondents who maintain that we should not make it a rule to operate upon cases of appendicitis as soon as the diagnosis is made. The matter is one of grave importance because the deaths from appendicitis in the United States alone have been estimated, from safe data, to amount to more than fifty thousand annually. Physicians carry into practice the ideas which they believe to be right, and patients are practically helpless in the matter because they must abide by the decisions of the physicians in whom they have placed confidence. Some physicians are wrong; some are right. The ones who are wrong treat as many patients as the ones who are right. Patients do not know the difference and they do not realize that deaths from appendicitis are usually unnecessary deaths.
Commentaire de travail de J. R. Romanelli et al., pp. 306
Journal: Endoscopy (2010)

See also: Natural orifice transluminal endoscopic surgery gastrotomy closure in porcine explants with the Padlock-G clip using the Lock-It systemEndoscopy 2010; 42(04): 306-310DOI: 10.1055/s-0029-1243950
Cystinuria
Authors: Charles R. Scriver
Journal: New England Journal of Medicine (1986)

Cystinuria is an old medical topic.1 While Napoleon and Wellington were preoccupied with the Peninsular War, Wollaston characterized the "cystic oxide" he found in some, but not all, samples of human urinary calculi.2 A century later, A.E. Garrod used cystinuria with great effect to illustrate his idea of human chemical individuality.3 Half a century after that, Dent and Rose4 and Harris et al.5 solved the riddle of cystinuria by showing that it represents an inborn error of membrane transport, not a defect of catabolism. This hyperaminoaciduria is inherited as an autosomal recessive phenotype. The mutant gene is common in humans, . . .
When Medical Tourism Is No Vacation
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ASSOCIATION SUBSCRIPTION.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacteriuria in the catheterized patient. Cystitis or pyelonephritis?
Authors: P. Gonick
Journal: JAMA (1975)

Seventy-two patients with indwelling urethral catheters had urine specimens cultured to detect bacteriuria. Bacterial sediments were examined to find the source of the bacteria, with use of an antibody immunofluorescence (IF) technique. Antibody coating demonstrated by fluorescence was considered evidence for pyelonephritis. In cystitis, the bacteria did not fluoresce. Repeat culture and immunofluorescence studies were done 3 to 18 weeks later. One third of the patients had a urinary infection. Two (13%) of the patients catheterized for one day and 17 patients (55%) catheterized four or more days had appreciable bacteriuria. One patient catheterized less than three days had positive IF, while 5 patients (16%) catheterized four or more days had positive IF. Only two of the ten patients observed, with an initial infection, had sterile urine on follow-up culture. On follow-up study, of the four patients with bacteriuria of renal origin, one showed a sterile urine, two had cystitis, and one still had pyelonephritis. (<i>JAMA</i>233:253-255, 1975)
Approaches and Constraints to Identification and Quantitation of Asbestos Fibers
Authors: Arthur M. Langer
Journal: Environmental Health Perspectives (1974)

Asbestos fibers, members of complex crystal–chemical systems, possess some range in characteristic properties. Identification of fibers requires morphological, structural, and chemical data. Most current work centers on identification of single, sublight-microscopic fibers present as contaminants in a range of media. Constraints encountered in the analysis of such materials are: sample preparation of the differing media; level of fiber exposure (contamination); presence (kind and amount) of other particles; tissue types and their different preparation techniques; homogeneity of samples and their preparations; use of proper instrumental technique; time required for analysis, and quantitation.
Law, Medicine and Minors
Authors: Donald Hayes Russell
Journal: New England Journal of Medicine (1968)

CHILD abuse has recently become a subject of great legislative interest. Within three short years — 1963 to 1965 — a total of 47 states enacted laws that called for the reporting of injuries inflicted on children. It is of interest to view these legislative efforts in the context of the dual issues of child protection and the rights and responsibilities of parents. Criminal law traditionally has forbidden the infliction of injury and cruelty by one person upon another, but it was not until 1874 that a court in New York City dealt specifically with the issue of the abuse . . .
AASLD Program
Journal: Hepatology (2008)

This joint one-day course will focus on aspects of viral hepatitis and fulminant liver failure in the setting of liver transplantation.The participant's increased knowledge will enhance the clinical management of patients with these conditions. Goals and Objectives:• Make the best practice decisions in the treatment and prevention of hepatitis B and hepatitis C with respect to liver transplantation.• Understand the nature and natural history of HCV infection in the setting of liver transplantation.• Understand acute liver failure and make treatment decisions based on natural history.
National Cancer Institute Monograph 33, May 1971 “Patterns in Cancer Mortality in the United States: 1950–1967” &lt;italic&gt;Editor&lt;/italic&gt;: Fred Burbank
Journal: JNCI Journal of the National Cancer Institute (1971)

National Cancer Institute Monograph 33, May 1971 “Patterns in Cancer Mortality in the United States: 1950–1967” Editor: Fred Burbank Get access JNCI: Journal of the National Cancer Institute, Volume 47, Issue 3, September 1971, Page 730, https://doi.org/10.1093/jnci/47.3.730-a Published: 01 September 1971