tbuckley/cabot-search huggingface dataset:
Next-generation sequencing (NGS) in advanced well differentiated pancreatic neuroendocrine tumors (WD pNETs): A study using MSK-IMPACT.
Authors: Nitya Prabhakar Raj, Tara Soumerai, Emily Valentino, Jaclyn Frances Hechtman, Michael F. Berger, Diane Lauren Reidy
Journal: Journal of Clinical Oncology (2016)

e15661 Background: Whole exome sequencing in WD pNETs demonstrated an increased number of mutations in chromatin modeling genes (MEN1, DAXX, and ATRX), and in the mTOR pathway. NGS brings this technology to the clinic but its relevance in practice has been questioned. In this prospective, IRB-approved study (NCT01775072), we used the MSK-IMPACT assay to perform NGS on WD pNETs in a routine practice setting. MSK-IMPACT, performed in a CLIA-compliant laboratory, is a multiplexed assay (Illumina HiSeq) providing full exon coverage of 410 cancer related genes, detecting base substitutions, small indels, copy number and select gene rearrangements. Methods: After written consent, tumor and germline DNA were analyzed. Genomic alterations were catalogued. Results: MSK-IMPACT results are available in 44 patients (pts). Actionable alterations were identified in 19/44 pts (43.2%). These actionable alterations included BRAF V600E (1 pt; 2.3%), and mutations in TSC1 (1 pt; 2.3%), TSC2 (7 pts; 15.9%), PTEN (5 pts; 11.4%), CDKN1B (2 pts; 4.5%), CDKN2A (4 pts; 9.1%), CDKN2B (4 pts; 9.1%), CDKN2C (1 pt; 2.3%), and ARID1A (6 pts; 13.6%). Other recurrently altered genes included MEN1 (27 pts, 61.4%), DAXX (18 pts, 40.9%), and ATRX (11 pts, 25.0%). Notably, 9 pts (20.5%) had alterations in the histone methyltransferase SETD2. All 9 pts presented with metastatic liver disease. 1/9 (11.1%) tumors were low grade; 6/9 (66.7%) were intermediate grade and 2/9 (22.2%) were high grade. All 9 pts received alkylating agents (temozolomide or dacarbazine); 8 pts (88.9%) had disease shrinkage and 1 pt (11.1%) had stable disease. Conclusions: The mutational landscape in our study was in line with prior work in pNET whole exome sequencing. In almost half of our cohort, potentially actionable alterations were identified through NGS but have not yet been shown to be therapeutically relevant. In addition, we report a novel finding of SETD2 alterations in pNETs. Most pts with SETD2 alterations had intermediate to high grade tumors and all pts responded to alkylating agents. Investigation is ongoing to clarify the relevance of the alterations identified through MSK-IMPACT and the clinical significance of SETD2 in WD pNETs.
MEDICINE AND THE LAW
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More on Desert Storm
Journal: JAMA (1991)

<h3>To the Editor.</h3> —The recent article by Keeler et al<sup>1</sup>regarding the effects of pyridostigmine bromide on the troops in Operation Desert Storm is pertinent. We have recently had experience with a unique first trimester exposure related to Operation Desert Storm. With the initial return of 2000 troops to Hawaii, two young women presented to Tripler Army Medical Center, Honolulu, Hawaii for counseling because of first trimester exposure to pyridostigmine and anthrax vaccine. Chemical agents classified as nerve gases are organophosphate compounds and act primarily by inhibiting acetylcholinesterase at cholinergic receptor sites. As a result, the neurotransmitter acetylcholine accumulates, causing hyperactivity at both muscarinic and nicotinic receptors.<sup>2</sup> Pyridostigmine, an acetylcholinesterase inhibitor used to treat myasthenia gravis, can be used as a pretreatment for these chemical agents because it occupies the active site of acetylcholinesterase, thereby blocking the action of the nerve agent. The drug has been used in
Farmer's Lung: Thermophilic Actinomycetes as a Source of "Farmer's Lung Hay" Antigen
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk for Meningococcal Disease Associated With the Hajj 2001
Journal: JAMA (2001)

Every year approximately two million pilgrims from more than 140 countries gather in Saudi Arabia for a pilgrimage to the holy places of Islam known as the Hajj. Coinciding with the Hajj pilgrimage during March 2000, Saudi Arabian health officials identified an outbreak of meningococcal disease; a substantial proportion of the isolates were the bacterial strain Neisseria meningitidis serogroup W-135. Four cases of meningococcal disease subsequently were identified among the estimated 15,000 pilgrims returning to the United States, their close contacts, and community. In addition, approximately 400 cases of meningococcal disease caused by N. meningitidis serogroup W-135 wereidentified worldwide during 2000. Whether an outbreak of meningococcal disease will recur in 2001 is unknown.
National Health Service
Authors: W. A. Barnes
Journal: BMJ (1948)

<h3>ABSTRACT</h3> Employment, along with education, is central to the promotion of social mobility and the reduction of health inequalities. For the most part, however, physicians have limited exposure to occupational medicine during their training and rarely receive much in the way of formal training about occupational issues except those that fall commonly within their area of specialisation. Here, we illustrate why work and good employment can be so important for health and, therefore, why it should matter to all physicians. Given that under half of the UK population have access to occupational health services through their employer, physicians should be able to recognise any harm to health caused by work, so we describe the principles of eliciting a good occupational history. There is an important relationship between unemployment and poor health which will be discussed, illustrating the importance of being able to support people with long-term conditions and disabilities to remain in work for as long as they wish to do so. Patients expect to be able to seek advice from their physician about taking time off work because of ill health, planning a return to work after sickness absence and whether or not they need to change their work status because of their health condition. Therefore, we describe the fitnote: what it is for, how to complete one well and what core principles are needed in order to give patients good advice about working.
"LESLIE'S ON CHIROPRACTIC"
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Method to Obtain a Well-Defined Fraction of Respirable para-Aramid Fibers
Authors: Roel Peter Frans Schins, Annie Gaudichet, Marie-Claude Jaurand
Journal: Environmental Health Perspectives (1993)

We developed a preparation method to obtain respirable-sized fractions of para-aramid fibers. The procedure, based on floatability, consists of stirring and subsequent settling of p-aramid pulp in distilled water. Two distinct phases are obtained, with small fibers in the upper part of the suspension, which represents about 33% of the total volume. Optimal results were obtained when 2.0 g pulp was stirred for 15 hr in 800 ml distilled water containing 0.125% ethanol and settled for 5 hr. The mass yield ranged between 0.4 and 0.6%, more than 90% of the particles had an aspect ratio > or = 3:1. The mean fiber length was about 6 microns, and the mean fiber diameter was about 0.4 microns as determined by transmission and scanning electron microscopy. The number of fibers obtained was 4 x 10(6) fibers/micrograms under our standard conditions.
Beginnings of U.S. Cancer Centers
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Beginnings of U.S. Cancer Centers Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 3, September 1985, Page 591, https://doi.org/10.1093/jnci/75.3.591 Published: 01 September 1985
Obsessive-Compulsive Disorder: Prevalence, Comorbidity, Impact, and Help-Seeking in the British National Psychiatric Morbidity Survey of 2000
Authors: Albina Torres
Journal: American Journal of Psychiatry (2006)

Objective: There is little information about obsessive-compulsive disorder in large representative community samples. The authors aimed to establish obsessive-compulsive disorder prevalence and its clinical typology among adults in private households in Great Britain and to obtain generalizable estimates of impairment and help-seeking. Method: Data from the British National Psychiatric Morbidity Survey of 2000, comprising 8,580 individuals, were analyzed using appropriate measurements. The study compared individuals with obsessive-compulsive disorder, individuals with other neurotic disorders, and a non-neurotic comparison group. ICD-10 diagnoses were derived from the Clinical Interview Schedule–Revised. Results: The authors identified 114 individuals (74 women, 40 men) with obsessive-compulsive disorder, with a weighted 1-month prevalence of 1.1%. Most individuals (55%) in the obsessive-compulsive group had obsessions only. Comorbidity occurred in 62% of these individuals, which was significantly greater than the group with other neuroses (10%). Co-occurring neuroses were depressive episode (37%), generalized anxiety disorder (31%), agoraphobia or panic disorder (22%), social phobia (17%), and specific phobia (15%). Alcohol dependence was present in 20% of participants, mainly men, and drug dependence was present in 13%. Obsessive-compulsive disorder, compared with other neurotic disorders, was associated with more marked social and occupational impairment. One-quarter of obsessive-compulsive disorder participants had previously attempted suicide. Individuals with pure and comorbid obsessive-compulsive disorder did not differ according to most indices of impairment, including suicidal behavior, but pure individuals were significantly less likely to have sought help (14% versus 56%). Conclusions: A rare yet severe mental disorder, obsessive-compulsive disorder is an atypical neurosis, of which the public health significance has been underestimated. Unmet need among individuals with pure obsessive-compulsive disorder is a cause for concern, requiring further investigation of barriers to care and interventions to encourage help-seeking.
P48 EGF/EGFR AXIS CONTRIBUTES TO THE PROGRESSION OF CHOLANGIOCARCINOMA THROUGH THE INDUCTION OF AN EPITHELIAL–MESENCHYMAL TRANSITION
Authors: A. Clapéron, M. Mergey, T.H. Nguyen Ho-Bouldoires, D. Vignjevic, D. Wendum, Y. Chrétien, F. Merabtene, A. Frazao, V. Paradis, C. Housset, N. Guedj, L. Fouassier
Journal: Journal of Hepatology (2014)
Medical Education, Registration and Hospital Service
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Die Schädigungen der Haut durch Beruf und gewerbliche Arreit.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABC of clinical electrocardiography: Conditions not primarily affecting the heart
Journal: BMJ (2002)

We assessed the test-retest reliability after one month in 23 consecutive patients; 77% of the Spearman's r values for individual items were >0.50, and no item performed badly (r<0.50) for more than two of the different methods of blood pressure measurement.Patients felt that all methods were worth the trouble to get accurate measurements.Methods differed significantly in their overall "problem" score (ambulatory, home, doctor, and nurse (n=145), F=193, P < 0.001; including self measurement in surgery (n=56) F=81, P < 0.001).The scoring of ambulatory monitoring for discomfort and disturbance of life and sleep explains why its overall score (the mean of all the items) was significantly higher than those for the other methods.Home readings performed significantly better than all the other methods in the overall score and were also ranked highest by most patients.
Collective Investigation of Disease.—
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic inflammatory demyelinating polyneuropathy in non‐Hodgkin's lymphoma
Authors: Jennifer J. Griggs, Christopher S. Commichau, Aaron P. Rapoport, Robert C. Griggs
Journal: American Journal of Hematology (1997)

A 42-year-old man was diagnosed with large cell non-Hodgkin's lymphoma 3 years after autologous bone marrow transplantation for Hodgkin's disease. The day before beginning systemic chemotherapy, the patient began to have symptoms of a sensorimotor neuropathy characterized by proximal and distal weakness, lower-extremity areflexia, elevated cerebrospinal fluid protein level, and evidence of demyelination on nerve conduction studies. Symptoms progressed despite two courses of intrathecal methotrexate, for possible lymphomatous meningitis, as well as systemic chemotherapy. The diagnosis of chronic inflammatory demyelinating polyneuropathy was made. Daily plasma exchange was performed for a total of 10 treatments with immediate improvement and eventual complete recovery in strength, sensation, and gait. A review of the literature confirms that inflammatory demyelinating polyneuropathy is a highly unusual but important cause of peripheral nervous system dysfunction. The potential for complete response to plasma exchange should be recognized in patients with symptoms, signs, and nerve conduction studies suggestive of chronic inflammatory demyelinating polyneuropathy. Am. J. Hematol. 54:332–334, 1997. © 1997 Wiley-Liss, Inc.
<i>QuickStats:</i> Age-Adjusted Percentage* of Adults Aged ≥18 Years Reporting a Lot of Pain,† Among Those Who Report Pain on at Least Some Days in the Past 3 Months,§ by Poverty Status¶ and Frequency of Pain — National Health Interview Survey, 2016–2017**
Journal: MMWR Morbidity and Mortality Weekly Report (2019)
Percutaneous Nephrolithotomy
Authors: Ralph V. Clayman
Journal: JAMA (1983)

Using electrohydraulic lithotripsy, we removed branched or staghorn calculi from four patients via a percutaneous nephrostomy tract with local anesthesia. There were no serious complications, and the patients were able to resume their preadmission activities immediately after discharge from the hospital. Our experience suggests that, eventually, all upper urinary tract calculi may be treatable by a percutaneous approach. (<i>JAMA</i>1983;250:73-75)
Highlights
Journal: JAMA Neurology (2018)

Antiepileptic Drug Use In Utero and Risk of Autistic Traits 160Exposure in utero to antiepileptic drugs is associated with increased risk of autistic traits in childhood.In this population-based cohort and Norwegian biobank study, Bjørk and coauthors found that the risk of autistic traits in children exposed to antiepileptic drugs in utero (n = 335) was significantly higher at 18 months of age when their mothers had not used folic acid supplements compared with children of mothers who had used supplements.Degree of autistic traits was inversely associated with maternal plasma folate concentrations and folic acid doses.Meador provides editorial perspective.
Modern Clinical Psychiatry
Authors: H. Keith Fischer
Journal: JAMA (1983)

The tenth edition of this highly successful series continues to feature the psychodynamic basis of modern clinical psychiatry, while integrating medical, neurophysiologic, and pharmacologic factors and recent progress in these fields. Adaptational aspects are included and are important, but the social aspects are somewhat less emphasized. The new<i>Diagnostic and Statistical Manual</i>(<i>DSM III</i>) classification system is used. A new coauthor (who unfortunately is no longer active as a psychiatrist) is introduced. Material is added and skillfully updated, although this is not an extensively rewritten effort. The new edition is longer by about 90 pages, however. Material is presented in essentially the same 34 chapter format of prior editions. References after each chapter are arranged under subtopics, and the index at the end of the book indicating subjects, tables, and illustrations is extensive and helpful. The material is readable, and the presentation by two authors has the advantage of integration
The authors reply
Authors: Dai-yang Li, Wen-jun Yin, Yi-hu Yi, Bi-kui Zhang, Jun Zhao, Chao-nan Zhu, Rong-rong Ma, Ling-yun Zhou, Yue-liang Xie, Jiang-lin Wang, Shan-ru Zuo, Kun Liu, Can Hu, Ge Zhou, Xiao-cong Zuo
Journal: Kidney International (2019)