tbuckley/cabot-search huggingface dataset:
Abstract 1228: Decreased Mitochondrial Biogenesis and Increased Pro-oxidant Activity Are Associated with Oxidative Impairment of Complex II in the Postischemic Heart
Authors: Jingfeng Chen, Chwen-Lih Chen, Brian Palmer, Jay L Zweier, Yeong-Renn Chen
Journal: Circulation (2007)

Increased O 2 ·− generated in mitochondria and NO is a key mechanism of cell death in the postischemic injury. Succinate ubiquinone reductase (SQR or Complex II) is a crucial segment of electron transport chain. Oxidative impairment of SQR has been observed in the postischemic myocardium. When rats are subjected to a 30 min coronary ligation, followed by a 24 h reperfusion, two polypeptides in tissue homogenate were found to react with the antibody against nuclear-encoded 29 kDa iron-sulfur protein (ISP) of SQR. One at 29 kDa corresponded to the mature form localized in mitochondria was present in normal amounts. The other with higher molecular weight 32 kDa corresponded to the precursor localized in cytosol was marked deficient. Similar results were observed when isolated heart was subjected to global ischemia (30min) and reperfusion (1h). Taken together, these results implicate mitochondria myopathy with an abnormality of biogenesis in the postischemic heart. The SQR mRNA level analyzed by quantitative real-time PCR was decreased 51%. Both mRNA and protein expressions of transcription coactivator PGC-1α were decreased in postischemic models 44% and 38% respectively, indicating a defect in the regulation and coordination of mitochondrial biogenesis. The mRNA levels of downstream transcription factors and antioxidant enzymes including NRF, TFAM, MnSOD, and UCP were similarly decreased; indicating that defect in mitochondrial biogenesis augments the oxidative stress in the postischemic heart. In addition, peroxynitrite formation was detected in the mitochondria of postischemic myocyte. The SQR isolated from myocardium was further used to study the interaction of NO with SQR in vitro . Under the conditions of enzyme turnover, SQR obtained after NO (25 fold excess) pretreatment gained catalytic function to generate hydroxyl radical detected by EPR spin trapping using DEPMPO. In the presence of catalase and iron chelator, the EPR signal of associated with DEPMPO/ · OH was completely abolished, suggesting the involvement of iron-H 2 O 2 dependent Fenton reaction. Direct EPR measurement at 77 °K indicated the formation of nonheme iron-NO complex, implying electron leakage to O 2 had occurred at the ISP of SQR and excess NO predisposed SQR to pro-oxidant activity.
Patient preferences for provider roles in collaborative breast cancer survivorship care.
Authors: Lauren P. Wallner, Paul Abrahamse, Christopher Ryan Friese, Steven J. Katz, Sarah T. Hawley
Journal: Journal of Clinical Oncology (2016)

184 Background: Prior studies have exploredbarriers to collaborative cancer care and suggest a need for greater clarity about clinician roles. However, little is known about patient’s preferences and expectations for which clinicians handle various aspects of care after primary cancer treatment. Methods: A weighted random sample of newly diagnosed breast cancer patients in the Georgia and Los Angeles SEER registries were surveyed approximately 6 months after diagnosis (expected final N = 2600, 70% current response rate). Patient preferences for which clinician handles the following aspects of care after treatment were ascertained: follow-up mammograms, screening for other cancers, general preventive care, treatment of comorbidities, physical symptoms, emotional symptoms, and reassurance about their breast cancer. Response categories included primary care clinician (PCP), cancer doctors, either or both. The associations between patient demographic and clinical factors with preferences for clinician roles were assessed using multinomial logistic regression. Results: In a preliminary sample (N = 1038), the majority of women preferred to see oncologists for mammograms (63%), other cancer screening (67%) and reassurance about their cancer (75%) and PCPs for general preventive care (80%), comorbid care (85%) and emotional symptoms (67%). Black women (vs. White) were more likely to prefer to see both clinicians for mammograms (OR: 3.7, 95%CI: 2.5, 5.5), screening for other cancers (OR: 2.1, 95%CI: 1.3, 3.2), reassurance about their cancer (OR: 2.1, 95%CI: 1.3, 3.2), and general preventive care (OR: 4.0, 95%CI: 2.1, 7.8). Black and Hispanic women were more likely to prefer to see both for comorbidity care (Black OR: 3.2, 95%CI: 1.6, 6.3; Hispanic OR: 2.6, 95%CI: 1.1, 6.3). Less than a high school education was also associated with a preference for seeing both clinicians for comorbidity care. Conclusions: While patients report clear preferences for which clinicians handle various aspects of their collaborative survivorship care, variation exists by race and education. Targeting these patients to clarify clinician roles may be particularly effective in interventions to improve collaborative cancer care.
Peer Review
Authors: B. Vittal Shenoy
Journal: JAMA (1990)

<h3>To the Editor. —</h3> The recent article "Quotational and Reference Accuracy in Surgical Journals"<sup>1</sup>illustrates a problematic lack of verification of original sources. I advise<i>JAMA</i>to insert a statement in its Instructions for Authors that all references must be read personally by the author(s). To provide a historical perspective, in the late 1830s Sir James Paget wrote biographies of distinguished scientists in the<i>Biographical Dictionary</i>, published by the then very important Society for the Diffusion of Useful Knowledge. As noted before,<sup>2</sup>he subsequently wrote: "I learnt more than ever the value or necessity of always referring, if possible, to the very book, volume, and page quoted from, or from which any statement is made, and the similar necessity of verifying every reference made from another. Nothing could better teach the difficulty, necessity, and rarity of accuracy in writing than did this work in biography."<sup>3</sup>
Announcement
Authors: Hans-Ulrich Wittchen, Carlo Faravelli, Corrado Barbui, Gen Komaki, David Healy, Nitesh Painuly, Debasish Basu, Noriyuki Kawamura, Scott B. Patten, Luca Abrardi, Barbara S. Kohlenberg, David O. Antonuccio, Steven C. Hayes, Elizabeth V. Gifford, Melissa P. Piasecki, Patricia Casey, Lee S. Cohen, Lori L. Altshuler, Zachary N. Stowe, Daniela Bartolozzi, Cristiana Cecchi, Fiammetta Cosci, Donato D'Adamo, Beatrice Lo Iacono, Claudia Ravaldi, Maria Alessandra Scarpato, Elisabetta Truglia, Simone Rosi, Carlo Faravelli, Luca Abrardi, Daniela Bartolozzi, Cristiana Cecchi, Fiammetta Cosci, Donato D'Adamo, Beatrice Lo Iacono, Claudia Ravaldi, Maria Alessandra Scarpato, Elisabetta Truglia, Paolo Maria Rossi Prodi, Simone Rosi, David Healy, Keiko Honda, Renee D. Goodwin, Shotaro Sakami, Akinori Nakata, Masaharu Maeda, Takayuki Maruoka, Stephen V. Faraone
Journal: Psychotherapy and Psychosomatics (2004)
Correction to: Evaluation of 167 Gene Expression Classifier (GEC) and ThyroSeq v2 Diagnostic Accuracy in the Preoperative Assessment of Indeterminate Thyroid Nodules: Bivariate/HROC Meta-analysis
Authors: Martyna Borowczyk, Ewelina Szczepanek-Parulska, Michał Olejarz, Barbara Więckowska, Frederik A. Verburg, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Katarzyna Ziemnicka, Marek Ruchała
Journal: Endocrine Pathology (2019)
Surgery
Authors: Arthur E. Baue
Journal: JAMA (1980)

In surgery the decade of the 1970s may be characterized best as a period of confirmation or reaffirmation of what was known—a consolidation of gains. Innovations, new procedures, and new techniques became established as accepted treatment. Certainly new approaches were developed and introduced during this period, but progress came not so much from the new as from doing better what already could be done. The innovations of the 1960s were solidified in the 1970s. What constitute advances in surgery? New operations? Technical adaptations? Advances made by surgeons? The results of surgical research (a subject in itself, difficult to define)? Under the rubric are included all of these positive steps that improve the care of patients with diseases that customarily require operative therapy. Thus, progress in surgery may be a new operation, a better diagnostic approach, a better method of support for injured or postoperative patients, or elimination of the need
Non-A, non-B hepatitis and antibody to hepatitis C virus
Authors: J. W. Mosley
Journal: JAMA (1990)

Stored serum samples from the Transfusion-transmitted Viruses Study in the 1970s were tested for the presence of antibody to hepatitis C virus (anti-HCV). Single specimens from five control subjects who did not receive transfusions tested negative for anti-HCV. Of four control subjects who did not receive transfusions and who developed non-A, non-B (NANB) hepatitis after hospitalization, three remained anti-HCV negative; the fourth person with postoperative NANB hepatitis tested anti-HCV positive before the operation. Five transfusion recipients with posttransfusion hepatitis B virus infection remained seronegative; a sixth with NANB hepatitis as well as hepatitis B virus infection had seroconversion for anti-HCV. Five of nine transfusion recipients with NANB hepatitis had anti-HCV seroconversion. These results show that present anti-HCV testing demonstrates an etiologic basis for approximately half of the cases of transfusion-associated NANB hepatitis, particularly those that develop chronicity. Although cases of NANB hepatitis without seroconversion may be explained otherwise, they may be caused by another, presently unidentified, virus. (<i>JAMA</i>. 1990;263:77-78)
Hormone Therapy and Menopausal Symptoms Among Women Participating in a Behavioral Lifestyle Intervention: The Women’s Healthy Lifestyle Project
Authors: Miriam A. Boraz, Laurey R Simkin-Silverman, Rena R. Wing, Elaine N. Meilahn, Lewis H. Kuller
Journal: Circulation (2001)

P91 The decision to take hormone replacement therapy (HRT) is a choice many women encounter when entering menopause. In light of controversy of the benefits and risks of HRT use, an important question to ask is on what basis are women taking HRT, and are they taking hormone therapy because they are at higher risk. The purpose of this study was to examine HRT use in women who are participating in a behavioral lifestyle intervention through the menopause. The Women’s Healthy Lifestyle Project (WHLP) was a 5-year randomized clinical trial designed to examine whether a behavioral lifestyle intervention could decrease the expected rise in cardiovascular risk through the menopause. A sample of 535 healthy premenopausal women, aged 44-50 years (M=47 + 1.9) participated in the study. The intervention was highly successful in buffering risk elevation through the 54-month visit. The control group gained 5.2 lb over the 54 month study and the intervention group remained 0.18 lb below baseline (p=.00). The intervention group’s LDLc increased by 3.5 mg/dl, and the control group’s LDLc increased by 8.9 mg/dl (p=.01). At the 54-month visit, there was no difference between the intervention and control groups in menopausal status, with 34.7% of the women postmenopausal. There was no difference between intervention and control groups with regard to HRT use, with 31.2% of the total sample reporting use of HRT. Further, there was no difference in menopausal symptoms between treatment groups. The women started HRT an average of 6 months after they missed a period. Analysis was done to examine predictors of HRT use in this group of women. Baseline cardiovascular risk factors did not predict HRT use at the 54-month visit. Moreover, the number of menopausal symptoms did not predict HRT use at 54 months. There was little difference between the women who were taking HRT and the women who were not taking HRT. There was a high use of HRT in this group of healthy, well-educated women. But an intensive lifestyle intervention did not change the use of HRT.
FcαRI (CD89) as a Novel Trigger Molecule for Bispecific Antibody Therapy
Authors: Thomas Valerius, Bernhard Stockmeyer, Annemiek B. van Spriel, Robert F. Graziano, Ingrid E. van den Herik-Oudijk, Roland Repp, Yashwant M. Deo, John Lund, Joachim R. Kalden, Martin Gramatzki, Jan G.J. van de Winkel
Journal: Blood (1997)

Promising results from clinical trials with unconjugated antibodies stimulated renewed interest in immune effector mechanisms of monoclonal antibodies (MoAbs). We investigated the potential of IgA as antibody isotype for cell- or complement-mediated tumor cell lysis and assessed the potential of its myeloid Fc receptor, FcαRI (CD89), as trigger molecule for bispecific antibody (BsAb)-mediated immunotherapy. Comparing hapten-directed antibodies of human IgA2 with IgG1 or IgG3 isotypes, we found all three to mediate effective killing of sensitized tumor target cells in whole blood assays. Analysis of effector mechanisms showed IgG-mediated lysis to be predominantly complement-dependent, whereas IgA-dependent killing was primarily effector cell-mediated. A comparison of effector cell populations in antibody-dependent cell-mediated cytotoxicity (ADCC) showed neutrophils to be most important for IgA-dependent tumor cell killing, involving FcαRI as shown with Fc receptor blocking antibodies. Reverse ADCC experiments against target cells sensitized with Fc receptor antibodies, or assays with FcαRI-directed bispecific antibodies confirmed FcαRI as effective trigger molecule in polymorphonuclear neutrophil (PMN)-mediated lysis. During granulocyte colony-stimulating factor (G-CSF ) therapy, (FcαRI × HER-2/neu) bispecific antibodies induced enhanced killing of HER-2/neu positive SK-BR–3 breast cancer cells in whole blood assays. This enhanced cytotoxicity was paralleled by increased PMN counts, which lead to higher effector to target cell ratios in G-CSF–primed blood. Furthermore, bispecific antibodies, directed to FcαRI and Candida albicans, enhanced neutrophils' phagocytosis of fungi. In summary, these results identify IgA as an effective antibody isotype for immunotherapy, working primarily via FcαRI on neutrophils. They suggest FcαRI-directed bispecific antibodies and G-CSF to be an attractive combination for malignant or infectious diseases.
Etiology and Treatment of Pars Interarticularis Defects
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Young adults with head and neck cancer express increased susceptibility to mutagen-induced chromosome damage
Authors: S. P. Schantz
Journal: JAMA (1989)

Factors that contribute to an increased prevalence of squamous cell carcinoma of the upper aerodigestive tract among young adults in the United States remain unknown. A potential etiologic factor may relate to a genetically controlled sensitivity to environmental carcinogens. This study, therefore, examined 20 young adult patients who had squamous cell carcinoma for mutagen-induced chromosome sensitivity. Lymphocytes from respective patients were cultured, exposed to the clastogen bleomycin, arrested during metaphase, and examined quantitatively for chromosome breakage. As compared with an age- and sexmatched control population, as well as a population of patients who had non— squamous cell carcinoma head and neck tumors, the young adult population with squamous cell carcinoma expressed a significantly increased number of bleomycin-induced chromosome breaks per cell. Furthermore, among the study patients, chromosome sensitivity was most apparent in the non—tobacco users and in patients less than 30 years of age. The expression of such chromosome fragility following mutagen exposure should be considered in epidemiologic studies that intend to define risk factors for development of head and neck cancer. (<i>JAMA</i>. 1989;262:3313-3315)
Lack of transmission of hepatitis B after surgical exposure
Authors: J. D. Meyers
Journal: JAMA (1978)

An orthopedic surgeon in whom hepatitis B subsequently developed participated in operations on 49 patients in the two months preceding his illness. Thirty of these patients were available for subsequent clinical and serologic follow-up: five had positive reactions for antibody to hepatitis B surface antigen (anti-HB<sub>s</sub>) and one had a positive reaction for hepatitis B surface antigen (HB<sub>s</sub>Ag) at the initial examination an average of 77 days after surgery. No new patients had either clinical or serologic evidence of hepatitis B during four months of subsequent follow-up (mean of 6.7 months after surgery). A control group of 56 orthopedic patients had a 25% prevalence of positive reactions for anti-HBs and negative reactions for HBsAg- this was not significantly different from the exposed group. The risk to patients of acquiring hepatitis B after surgical exposure in this setting from a surgeon is low. (<i>JAMA</i>240:1725-1727, 1978)
Reply
Authors: M. Hakim
Journal: Thorax (1985)

Role of automatic staplers in the aetiology of broncho- pleural fistula SIR,-In their article in January 1985 (40:27-31) Mr M Hakim and Mr BB Milstein reported on the incidence of bronchopleural fistula following pneumonectomy.They suggest that the use of the TA-55 Premium instrument contributes to a significantly higher rate of bronchopleural fistula following pneumonectomy than the original style and indicate that the differences are related to differences in design and function of the two staplers.
Coming Back
Authors: Frank Conaway
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgeon, USA
Authors: Marjorie C. Meehan
Journal: JAMA (1966)

Frank Slaughter practiced surgery in Virginia and Florida and served in the Army Medical Corps during World War II. Meanwhile, he began writing novels and now has had 46 books published since 1941. The most recent,<i>Surgeon, USA</i>, is an exciting story which utilizes his knowledge of medicine and the army. Any doctor who has military service will recognize some situations faced by the hero—a good old-fashioned admirable character unlike the "anti-hero" of so many modern works. But probably few heroes will have been able to shine in so many ways. This one was a successful surgeon, a capable administrator, an advisor on preventing a meningitis epidemic. Meanwhile he defended a mildly liberal viewpoint (in favor of the United Nations) to the extent of being threatened with congressional investigation; destroyed a John Birch type organization; and competed with his congressman for the affection of—alternately—a senator's beautiful daughter and a brilliant
The Collected Papers of Adolf Meyer. Volume III: Medical Teaching
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magnesium Sulfate for Preeclampsia
Journal: New England Journal of Medicine (2003)

story became widely known.As Maddox describes it in an epilogue, entitled "Life after Death," what started as an embarrassment for Nathan Pusey, then president of Harvard University (whose press decided not to publish Watson's account, which went on to become a bestseller), served as a wake-up call for those who knew and respected Franklin's contributions to the discovery of the double helix.
Hemodialysis and pregnancy
Authors: W. M. Trebbin
Journal: JAMA (1979)

When severe renal failure requiring hemodialysis complicates pregnancy, there is hesitation to continue the pregnancy. However, successful hemodialysis in pregnancy is being reported with growing frequency. Fetal survival and even conception is possible in patients undergoing dialysis. (<i>JAMA</i>241:1811-1812, 1979)
Intravenous penicillin desensitization and treatment during pregnancy
Authors: P. R. Ziaya
Journal: JAMA (1986)

Untreated syphilis during pregnancy may result in stillbirth in one fourth of cases, while in infants who survive, there may be serious immediate and delayed manifestations. Penicillin is the drug of choice for treating both mother and fetus. We describe a woman with an allergy against both major and minor determinants of penicillin in whom syphilis was diagnosed on routine obstetric screening. Her obstetric history included one vaginal delivery at term and four subsequent spontaneous abortions at 12 to 16 weeks. The patient underwent desensitization utilizing graduated intravenous doses of penicillin followed by treatment with a constant infusion for eight days. She experienced no serious allergic reactions requiring alteration of therapy. We conclude that antibiotic desensitization may be a safe alternative during pregnancy if performed with careful monitoring. In this case, it allowed use of penicillin rather than less desirable alternatives. (<i>JAMA</i>1986;256:2561-2562)