tbuckley/cabot-search huggingface dataset:
THU0384 Performance of The Asas Classification Criteria for Axial and Peripheral Spondyloarthritis – A Systematic Literature Review and Meta-Analysis
Authors: A. Sepriano, R. Rubio, S. Ramiro, R. Landewé, D. van der Heijde
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The Assessment of SpondyloArthritis international Society (ASAS) has developed and validated classification criteria for axial spondyloarthritis (axSpA) and peripheral SpA (pSpA). Following their release, the ASAS criteria have been "challenged" in different cohorts, thus warranting a review of the so-far accumulated evidence on the criteria validity and applicability. <h3>Objectives</h3> To summarize the evidence on the performance of the ASAS classification criteria for axSpA (also imaging and clinical arm separately), pSpA and the entire set of SpA, when tested against the Rheumatologist9s diagnosis ("reference standard"). <h3>Methods</h3> A systematic literature review was performed to identify eligible studies. Only studies with full-text available were included and, thereafter, raw data was obtained from the authors of the selected publications. A meta-analysis was performed to obtain pooled estimates for sensitivity, specificity, positive (LR+) and negative (LR-) likelihood ratios, by fitting random effects models. With a series of sensitivity analyses we assessed the possible effects of: i) target population (original validation study inclusion criteria <i>vs</i> different inclusion criteria); iii) setting (hospital <i>vs</i> community); and iii) disease duration (&lt;2 years <i>vs</i> ≥2 years). <h3>Results</h3> Of the 1,647 retrieved articles, 8 fulfilled the inclusion criteria (N=5,042 patients). The entire set of the ASAS SpA criteria yielded a high pooled sensitivity (73%) and specificity (88%), but with limited available data (Table). Similarly good results were found for the axSpA criteria (sensitivity: 82%; specificity: 88%) in a larger number of studies. Splitting the axSpA criteria in "imaging arm only" and "clinical arm only" resulted in much lower sensitivity (30% and 23% respectively) but retaining very high specificity (97% and 94% respectively). The "imaging arm only" compared to the "clinical arm only" had a much higher LR+ (9.6 <i>vs</i> 4.5, respectively). The pSpA criteria were less tested than the axSpA and have shown a similarly high pooled specificity (87%) but lower sensitivity (63%). Sensitivity analyses yielded consistently good results for the axSpA criteria (sensitivity (range): 78% - 86%; specificity (range): 86% - 93%). For pSpA there were few studies therefore hampering sensitivity analyses. <h3>Conclusions</h3> Accumulated evidence from more than 5,000 patients confirms the good performance of the various ASAS SpA criteria as tested against the Rheumatologist9s diagnosis. The clinical and imaging arm have high specificity but lack sensitivity if applied separately, indicating that the full set of axSpA criteria is the preferred set. <h3>Disclosure of Interest</h3> None declared
Consensus panel says benefits of screening women for ovarian cancer currently unproven
Authors: C. Marwick
Journal: JAMA (1994)

A NATIONAL Institutes of Health consensus development panel has some advice for women, and their physicians, who may be concerned about ovarian cancer. Panel chair Vicki Seltzer, MD, head of obstetrics and gynecology at Long Island Jewish Medical Center, New Hyde Park, NY, says, "Women are overly worried. The risk of ovarian cancer is only 1 in 70 unless the woman belongs to a high-risk group." "I think there is a tremendous fear of ovarian cancer, and it greatly exceeds the risk," says panel member Carolyn Hendricks, MD, a medical oncologist in practice in Rockville, Md. Risk factors for ovarian cancer include nulliparity, North American or Northern European descent, a history of endometrial, colon, or breast cancer, and a family history of ovarian cancer. However, there is a small percentage of women who are at significantly increased risk of disease due to three hereditary ovarian cancer syndromes: breast-ovarian cancer syndrome,
Epidemiology of anorexia nervosa.
Journal: BMJ (1973)

11 of 27 Pseudomonas, 5 of 11 Proteus mirabilis, and in none of 4Klebsiella and 1 P. vulgaris infection.In none of these studies was selection of patients based on demonstrated sensitivity of the causative organism to carbeni- cillin combined with resistance to other drugs.If this criterion were adopted, what are the indications likely to be ?First, and without question, Pseudomonas infections.E. coli is a sensitive species, but it is also normally sensitive to many other drugs more agreeable to administer than this one, and resistance to every one ofthem is improbable.It was stated at the symposium that "all strains of Proteus" are sensitive, but this is mistaken.P. mirabilis is normally sensitive, but if it forms penicillinase (and many strains do) it is not.This was clearly stated in the original paper announcing the discovery of carbenicillin4 and also emphasized by L. P. Garrod and F. O'Grady in their well-known book.5 P. mirabilis is specifically named as a cause of infection in four of these papers, but none of them makes any reference to this distinction or states whether the strains concerned formed penicillinase.If they did, failure is not surprising; if they did not, the infection might have responded equally well to ampicillin.The uncommon indole- forming Proteus species are sensitive to carbenicillin alone among the penicillins, but the single representative of these, a P. vulgaris infection, was a failure.Klebsiella are well known to be resistant, and it is not surprising that these infections did not respond.It is not too harsh a judgement on this drug to conclude that the outpatient treatment of Pseudomonas infections is almost the only indication for it.These differ from most others in being insusceptible to any other oral therapy.A convincing case for its use in other infections has not yet been made out.
Expression of HLA class II antigens on skin fibroblasts in scleroderma
Authors: M C Branchet, S Boisnic, O Blétry, L Robert, D Charron, C Francès
Journal: British Journal of Dermatology (1992)

Skin biopsies were taken from 11 patients with morphoea, nine with acrosclerosis and 10 with diffuse systemic sclerosis and processed for immunohistochemical studies using a panel of monoclonal antibodies including antibodies to MHC class II antigens. A significantly higher percentage of HLA-DR positive dermal cells were observed in the reticular dermis in biopsies from patients with morphoea (44.1 +/- 16.2%), acrosclerosis (15.9 +/- 5.4%) and systemic sclerosis (39.5 +/- 2.3%) when compared with the controls (6.6 +/- 2%). A smaller percentage of dermal cells also expressed HLA-DP and -DQ. The degree of monocnuclear cell infiltrate in the biopsies, however, did not correlate with the percentage of HLA class II positive fibroblasts. In organ culture, the expression of the HLA class II antigens was almost totally lost after 3 days and was no longer detected on fibroblasts after 3 weeks of culture.
Soft-tissue tracheal mass associated with previously resected bronchogenic carcinoma
Authors: L. B. Milner
Journal: JAMA (1981)

<h3>History</h3> A 64-year-old man with a known history of squamous cell carcinoma of the lung was admitted for increasing shortness of breath. In August 1975, a chest film showed a right lower lobe mass, which led to resection of a squamous cell carcinoma. In October 1978, he had recurrence of the carcinoma in the same general area, which was resected in November 1978. In June 1979, gradual onset of shortness of breath developed, which increased in the three weeks before admission on Sept 4, 1979. An admission chest film demonstrated increased prominence of the right hilum, which subsequently was evaluated with tomography. The tomograms demonstrated recurrent tumor in the right hilar and subcarinal areas. Within the midtrachea itself along the right lateral wall, a 2-cm well-defined soft-tissue density was demonstrated (Figure, arrowheads) (not apparent on plain films). Because of the tracheal mass, the patient underwent straight-tube bronchoscopy. No intratracheal lesion
Letter: Acute lymphoblastic leukemia and histiocytic medullary reticulocytosis
Authors: Robert F. Marvin
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Dr Shreiner's article (231:838, 1975) suggests a stem-cell abnormality as the possible underlying cause of the patient's acute lymphoblastic leukemia and subsequent histiocytic medullary reticulosis. Further thought on the cause of the latter disease is provoked by the existence of 25 cases of histiocytic medullary reticulosis seen at Mulago Hospital in Uganda over a seven-year period.<sup>1-2</sup> Good American articles often fail to note the existence of this large number of cases.<sup>3</sup>Serck-Hansen and Purchit have postulated that the increased incidence of cases in the tropics may be due to increased stimulation of the reticuloendothelial system, resulting from frequent infections or from malnutrition beginning in early infancy.<sup>1</sup>It may be of additional interest that many of these cases come from the same area where there is an increased incidence of Burkitt lymphoma.
PERMANENT TENURE OF OFFICE FOR HEALTH OFFICERS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Educational Programs in Areas Allied With Medicine
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serotonin-Induced Coronary Contraction Increases After Blood Cardioplegia-Reperfusion
Authors: Caroline Métais, Jiany Li, Jian Li, Michael Simons, Frank W. Sellke
Journal: Circulation (1999)

Background —Coronary contraction has been implicated in causing suboptimal myocardial function after coronary bypass surgery. Addition of blood to cardioplegic solutions has been shown to improve endothelial function after cardioplegia. In this study, the effects of blood cardioplegia and brief reperfusion on vascular reactivity in patients with coronary artery disease and the expression (mRNA and protein) of enzymes involved in vasomotor regulation were examined. Methods and Results —The atrial appendages of patients undergoing coronary artery surgery were harvested before cardiopulmonary bypass (control, n=8) and after bypass from a nonischemic tissue atrial segment exposed to cold, hyperkalemic blood cardioplegia (mean, 60 minutes) and a brief period (10 minutes) of reperfusion (CP-Rep, n=8). Responses of atrial arterioles were studied in vitro with video-microscopy. Reverse-transcriptase polymerase chain reaction and Western blotting were used to examine the expressions and protein content, respectively, of enzymes involved in vasomotor regulation. Serotonin caused a minimal dilation under baseline conditions but after CP-Rep elicited a potent contractile response that was inhibited in the presence of the selective inducible cyclooxygenase (COX-2) inhibitor NS398. Substance P caused an endothelium-dependent relaxation of atrial arterioles through release of nitric oxide, and ADP caused relaxation mediated through release of prostaglandins. After CP-Rep, relaxation to substance P was impaired, whereas endothelium-independent relaxation to nitroprusside and response to ADP were unchanged. Expression and protein level of COX-2 were significantly increased after CP-Rep. In contrast, expression of inducible (nitric oxide synthase-2) or constitutive endothelial (nitric oxide synthase-3) nitric oxide synthase, prostacyclin synthase, and constitutive cyclooxygenase (COX-1) were not altered after CP-Rep. Conclusions —CP-Rep increases serotonin-induced contraction of human microvessels caused by the release of products of COX-2 and the impaired release of nitric oxide. These findings have implications regarding altered coronary microvascular regulation and the cause of coronary spasm after cardiac surgery.
Hummingbirds
Authors: Beatriz Rodriguez
Journal: Annals of Internal Medicine (2012)

Ad Libitum21 February 2012HummingbirdsBeatriz Rodriguez, MDBeatriz Rodriguez, MDFrom Rockford, IL 61107.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-4-201202210-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The hummingbirds came back todaythe smallest glowing green arrayedone with ruby ringed neckone with parchment humbly dressed.We love to watch them with their beakslike spears into the nectar reachthen lift their heads in vigilanceand give a penetrating glance.They know, why we stop and stareto see them freeze—suspended therean ornament outside of timea soul, come down to look at mine.Beatriz Rodriguez, MDRockford, IL 61107 Author, Article, and Disclosure InformationAffiliations: From Rockford, IL 61107.Current Author Address: Beatriz Rodriguez, MD, 1826 Rothschild Lane, Rockford, IL 61107; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 February 2012Volume 156, Issue 4Page: 308KeywordsInterleukins ePublished: 21 February 2012 Issue Published: 21 February 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
GCT-15. INTEGRATED CLINICAL, HISTOPATHOLOGICAL, AND MOLECULAR DATA ANALYSIS OF 190 CENTRAL NERVOUS SYSTEM GERM CELL TUMORS FROM THE IGCT CONSORTIUM
Authors: Hirokazu Takami, Koichi Ichimura, Kohei Fukuoka, Akitake Mukasa, Nobuhito Saito, Yoshitaka Narita, Soichiro Shibui, Yoichi Nakazato, Ryo Nishikawa, Masao Matsutani
Journal: Neuro-Oncology (2020)

Abstract BACKGROUND We integrated clinical, histopathological, and molecular data of central nervous system germ cell tumors to provide insights into their management. METHODS Data from the Intracranial Germ Cell Tumor Genome Analysis Consortium were reviewed. A total of 190 cases were classified as primary GCTs based on central pathological reviews. RESULTS All but one of the cases that were bifocal (neurohypophysis and pineal glands) and cases with multiple lesions including neurohypophysis or pineal gland were germinomas (34 of 35). Age was significantly higher in patients with germinoma than other histologies. Comparison between tumor marker and histopathological diagnoses showed that 18.2% of histopathologically diagnosed germinomas were marker-positive and 6.1% of non-germinomatous GCTs were marker-negative, suggesting a limitation in the utility of markers or histopathology alone using small specimens for diagnosis. Comparison between local and central histopathological diagnoses revealed a discordance of 12.7%. Discordance was significantly less frequent in biopsy cases, implying difficulty in detecting all histopathological components of heterogeneous GCTs. Germinomas at the typical sites (neurohypophysis or pineal gland) showed a better PFS than those at atypical sites (p=0.03). A molecular-clinical association study revealed frequent MAPK pathway mutations in males (51.4 vs 14.3 %, p=0.007), and PI3K/mTOR pathway mutations in basal ganglia cases (p=0.004). Basal ganglia cases also had frequent chromosomal losses. Some chromosomal aberrations (2q, 8q gain, 5q, 9p/q, 13q, 15q loss) showed potential prognostic significance. CONCLUSIONS These in-depth findings of this study regarding the clinical and molecular heterogeneity will increase our understanding of the pathogenesis of this enigmatic tumor.
Civil Defense Agency
Authors: Thomas F. Maher
Journal: New England Journal of Medicine (1955)

MEDICAL PLANNING FOR CARE OF MASS CASUALTIES IN DISASTERIn long-term planning to establish emergency medical care for great numbers of casualties in a disaster it is necessary to analyze existing resources of medical personnel, hospital facilities, medical equipment and supplies within the Commonwealth. The optimum benefit will be derived from these resources in combating any disaster by comprehensive and detailed planning beforehand.In an enemy attack without warning with thermonuclear weapons the major cities of Massachusetts would have several hundred thousands of surviving casualties needing immediate hospitalization. Therefore, the great destructive power of modern thermonuclear weapons makes it imperative, . . .
A-wake?
Authors: L. Farrell
Journal: BMJ (1997)

The authors report a girl with autosomal recessive congenital muscular dystrophy linked to chromosome 6 (MDC1A) who carries a homozygous out-of-frame deletion in exon 56 of the <i>LAMA2</i> gene but has a mild phenotype. She is still ambulant at age 13 years, shows white matter abnormalities on MRI, and traces of laminin α2 in her muscle biopsy with one of three antibodies used. This patient suggests that modulating factors can be associated with a less severe clinical phenotype in MDC1A.
SERVETUS (1509-1553) CONDEMNED HERETIC
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
565O_PR Predictors of financial catastrophe following cancer in a high-middle-income Asian country
Authors: N. Bhoo Pathy, C-W. Ng, R. Sullivan, G.C. Lim, M. Mellor, N.S. Ibrahim Tamim, M. Kimman, S. Subramaniam, P-P. Goh, C-H. Yip
Journal: Annals of Oncology (2016)
Computed tomography in the investigation of dementia
Authors: J. R Bradshaw, J L G Thomson, M J Campbell
Journal: BMJ (1983)

To assess the value of computed tomography in investigating patients with dementia, 500 consecutive patients presenting with a provisional clinical diagnosis of dementia of recent onset were reviewed and the results analysed in a computer.Most patients had either cerebral atrophy or infarction, but 82 patients had a normal scan and 42 others had tumours.More than 10% of all patients, including 5% with no other symptoms or signs, had a treatable lesion.Various associated symptoms and signs were useful pointers to such a treatable lesion and clearly indicated computed tomography.Accurate diagnosis is the cornerstone of proper management, and if a few patients with treatable lesions can be identified then the benefits to all concerned may be incalculable.
Retinal hemorrhages in subacute carbon monoxide poisoning. Exposures in homes with blocked furnace flues
Authors: J. S. Kelley
Journal: JAMA (1978)

Three incidences of carbon monoxide poisoning occurred owing to defective heating systems. Twelve persons were affected; of these, three lost their lives. Because the symptoms of carbon monoxide poisoning closely resemble flu and other common illnesses, correct diagnosis was not made as promptly as it might have been. Hemorrhages were found in the nerve fiber layer of the retina in all five of the patients who had been exposed for more than 12 hours. It is our contention, therefore, that complete examination of the patient should always include ohthalmoscopy, and that the finding of retinal hemorrhages, in addition to nausea, headache, and dizziness, should alert the physician to the possibility of carbon monoxide poisoning. (<i>JAMA</i>239:1515-1517, 1978)
Text Omitted.
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal