tbuckley/cabot-search huggingface dataset:
Temozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group
Authors: H. Gogas, A. Polyzos, D. Tsoutsos, P. Panagiotou, T. Iconomou, S. Papadopoulos, O. Papadopoulos, S. Agarwala, I. Stavrinidis, G. Fountzilas
Journal: Journal of Clinical Oncology (2005)

7554 Background: There is now increasing evidence that a constitutive expression of cycloxygenase (COX)-2 plays a role in the development and progression of malignant epithelial tumors. Expression of COX-2 was determined by immunohistochemistry in 93% of melanomas. Temolozomide (T) has demonstrated activity against melanoma and has been investigated as single agent or in combination. We designed a phase II study to assess the efficacy and toxicity of the combination of T and Celecoxib (a COX-2 inhibitor) in patients with advanced melanoma. Patients and Methods: From January 2003 to July 2004, 52 patients were enrolled in the study. 19 patients were M1a, 6 patients were M1b and 27 M1c. Patients received T 200mg/m2 /day po for 5 consecutive days every 4 weeks and Celecoxib 400 mg BID po for maximum of 6 cycles. Celecoxib was continued until progression. Results: The median age was 63 years. There were 29 males and 23 females. Among 50 evaluable patients there were 11 (21.5%) objective responses including 5 CR and 6 PR. Responses were documented in soft-tissue and liver (2 patients). Twenty (38.5%) had stabilization of their disease, and 19 (36.5%) progressed. The median TTP was 4.6 months and the median survival was 9.6 months. Twenty-two patients (41.5%) completed all cycles of treatment. Median relative dose intensity of Temozolomide was 0.99 (range, 0.6 - 1.2). Immunohistochemistry results will be presented at the meeting. Most commonly seen toxicities included anemia (27.5%), neutropenia (17.5%), thrombocytopenia (33%), nausea/vomiting (75%), gastrointestinal (52%) and fatigue (46.5%). One patient discontinued due to severe toxicity. Conclusion: The combination of Temozolomide and Celecoxib provides substantial clinical benefit in patients with manageable toxicity. Randomized studies are needed to explore the role of Celecoxib in combination with chemotherapy or as maintenance treatment in these patients. This study was supported by unrestricted educational grant by Pfizer. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Pfizer
MALARIAL DYSENTERY.
Authors: WILLIAM BRITT BURNS
Journal: JAMA (1903)

One has but to review the literature of dysentery to arrive at the conclusion that there is no fixed etiologic factor in this disease; that the lesions, which are mainly confined to the large intestine, are quite characteristic, but are induced by several different agents, is a pretty constant finding, and is worthy of consideration. The<i>Amœba coli</i>is designated as the specific causative factor of dysentery, but here one is confronted with the fact that these bodies are found in less than one-half of the cases of all varieties and stages of the disease, and that the colon may be the normal habitat of amebæ, not only of this, but other amebæ—<i>Amœba guttula, diaphana, vermicularis, oblonga, reticularis and proteus</i>—which, it may be, are quite as culpable as<i>Amœba coli</i>. Moreover, these bodies are usually accompanied by other organisms, some pathogenic, and others which, by the proper environment,
Psychodermatology U.K.
Authors: S Massoud, J Alassaf, A Bewley
Journal: British Journal of Dermatology (2020)

Psychodermatology is a newer emerging subspecialty of dermatology.Psychocutaneous clinics are a multidisciplinary approach dealing with psychological or psychiatric elements related to skin diseases.Two previous studies in 2004 and 2010 highlighted the deficiency of psychodermatology services in the U.K. They have shown significant variability in the national provision of psychodermatology services, despite evidence that these services are highly in demand and highly cost-efficient.The current study assesses psychodermatology service provision 8 years after the last study and aims to assess what developments have been made.In conjunction with BBC Radio 5 Live, a survey questionnaire was distributed across the U.K. via e-mail to all members of the British Association of Dermatologists, and all members of Psychodermatology U.K. The survey consisted of 13 questions regarding the availability of psychodermatology services and psychological support to dermatology patients.Basic percentages were used to analyse quantitative data and content analysis for qualitative data.Our results showed that less than a quarter of the responders (n = 40/170) have access to a dedicated psychocutaneous service.Additionally, the psychodermatology units do not have a unified configuration.There is a noticeable variation in the type of clinic, team members, frequency of the clinic and available psychological or psychiatric support.Only around 5% of the clinics across the U.K. provide a psychodermato-oncology service and even fewer provide paediatric psychodermatology (5%).However, research in psychodermatology medicine was reported in around 12% of the clinics.In conclusion, psychocutaneous services in the U.K. have improved to some extent over the last decade.The service has become more widely available across the country, and the investment in research is promising, but it is still insufficient and unable to fulfil patient demand, especially vulnerable individuals like children and dermatooncology patients.
Erratum: Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Authors: Christian B Vaegter, Pernille Jansen, Anja W Fjorback, Simon Glerup, Sune Skeldal, Mads Kjolby, Mette Richner, Bettina Erdmann, Jens R Nyengaard, Lino Tessarollo, Gary R Lewin, Thomas E Willnow, Moses V Chao, Anders Nykjaer
Journal: Nature Neuroscience (2011)
Assessment of non-mydriatic photography in detection of diabetic retinopathy
Authors: R. Williams, S. Nussey, G. Thompson
Journal: BMJ (1986)

measured during this period may be an unreliable marker.For Dr Holt and colleagues to base diagnosis ofcyclosporin nephrotoxicity on only the absence of obstruction or histological signs of rejection seems unsatisfactory; some characteristic histological aspects of nephrotoxicity have been described' that they did not mention.Moreover, the possibility of viral infections that cause renal dysfunction cannot be excluded, mainly in the first weeks after transplantation.There is a discrepancy in the study: although its aim was to investigate the relation between the cause of renal graft dysfunction and trends in predose blood cyclosporin concentrations during the week before the episode of renal dysfunction, the authors considered the cyclosporin concen- trations in the week before biopsy, and the median time between transplantation and graft biopsy was two weeks, whereas that between transplantation and rejection episodes was five weeks.Moreover, the authors do not report the daily cyclosporin dose given in the week before renal biopsy and any changes during this period.They do say that the cyclosporin dose was reduced whenever blood values were over 666 nmol/l (800 ng/ml), and a reduction might in fact favour rejection, thus explaining the occurrence of rejections in some subjects with high cyclosporin values.We believe that details of reproducibility of the method not only at 416 nmol/l (500 ng/ml) but also at the lower and upper ends of the standard curve could usefully have been included, as well as data on a control group of patients with neither toxicity nor rejection and their mean cyclosporin levels.
Pseudoneoplasia
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Picswitch
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Life-threatening hypersensitivity to sulindac
Authors: F. E. Smith
Journal: JAMA (1980)

LIFE-THREATENING hypersensitivity after administration of sulindac has not been reported, to our knowledge, although fatal reactions have been reported to other nonsteroidal anti-inflammatory drugs.<sup>1,2</sup>We believe the following case represents a severe hypersensitivity reaction. <h3>Report of a Case</h3> An 18-year-old man was seen with acute polyarthritis and fever on Feb 25, 1979. Investigation showed evidence of viral or bacterial infection. History and physical examination findings were consistent with rheumatoid arthritis. Rheumatoid factor was positive at 1:320 and antinuclear antibodies positive at 1:80 with a nucleolar pattern. The ESR was 65 mm/hr. A tentative diagnosis of rheumatoid arthritis was made, and treatment was started with a combination of aspirin, magnesium hydroxide, and dried aluminum hydroxide gel (Ascriptin). Although his joint disease improved and fever resolved, epigastric pain developed that was unrelieved by antacids. On June 11, Ascriptin therapy was discontinued, and treatment was started with sulindac, 150 mg twice a
Health Effects of Acid Aerosols Formed by Atmospheric Mixtures
Authors: Michael T. Kleinman, Robert F. Phalen, William J. Mautz, Richard C. Mannix, Thomas R. McClure, T. Timothy Crocker
Journal: Environmental Health Perspectives (1989)

Under ambient conditions, sulfur and nitrogen oxides can react with photochemical products and airborne particles to form acidic vapors and aerosols. Inhalation toxicological studies were conducted, exposing laboratory animals, at rest and during exercise, to multicomponent atmospheric mixtures under conditions favorable to the formation of acidic reaction products. Effects of acid and ozone mixtures on early and late clearance of insoluble radioactive particles in the lungs of rats appeared to be dominated by the oxidant component (i.e., the mixture did cause effects that were significantly different from those of ozone alone). Histopathological evaluations showed that sulfuric acid particles alone did not cause inflammatory responses in centriacinar units of rat lung parenchyma (expressed in terms of percent lesion area) but did cause significant damage (cell killing followed by a wave of cell replication) in nasal respiratory epithelium, as measured by uptake of tritiated thymidine in the DNA of replicating cells. Mixtures of ozone and nitrogen dioxide, which form nitric acid, caused significant inflammatory responses in lung parenchyma (in excess of effects seen in rats exposed to ozone alone), but did not damage nasal epithelium. Mixtures containing acidic sulfate particles, ozone, and nitrogen dioxide damaged both lung parenchyma and nasal epithelia. In rats exposed at rest, the response of the lung appeared to be dominated by the oxidant gas-phase components, while responses in the nose were dominated by the acidic particles. In rats exposed at exercise, however, mixtures of ozone and sulfuric acid particles significantly (2.5-fold) elevated the degree of lung lesion formation over that seen in rats exposed to ozone alone under an identical exercise protocol.
Temperature Regulation in the Newborn Infant
Authors: William A. Silverman, John C. Sinclair
Journal: New England Journal of Medicine (1966)

Modification of Cold-Induced ThermogenesisThere is good evidence that the sympathetic nervous system is involved in the control of neonatal nonshivering heat production in a number of animal species. The infusion of small amounts of norepinephrine causes a large rise in total oxygen consumption and in local heat production in brown adipose tissue in the newborn rabbit.13 Cold-induced hypermetabolism is abolished by ganglion-blocking agents.17 Moore17 has shown that both norepinephrine-induced and neonatal nonshivering thermogenesis decline with advancing age in the kitten. Newborn human infants also appear to respond to the infusion of small amounts of norepinephrine with increased metabolism18; . . .
Intranasal Cyanocobalamin
Authors: Devin N. Wenig
Journal: JAMA (1992)

<h3>To the Editor.</h3> —We read with interest the letters by Dr Heimburger<sup>1</sup>and Drs Hathcock and Troendle<sup>2</sup>concerning the use of intranasal cobalamin and the availability of clinical studies conducted with the product. In September 1987, Nastech Pharmaceutical Company, Inc, submitted to the Food and Drug Administration's Division of Metabolic and Endocrine Drug Products a new drug application for the use of intranasal cyanocobalamin in treating vitamin B<sub>12</sub>deficiency anemias including pernicious anemia. The clinical studies in support of our application clearly show that the intranasal administration of 500 μg of cyanocobalamin once per week is both safe and effective in maintaining therapeutic blood levels of the vitamin. The advantages of the nasal route of administration as opposed to the injection are apparent. It eliminates the high cost and inconvenience of receiving monthly intramuscular injections that often result in patients' discontinuing therapy. Heimburger's letter makes mention of
Pseudothrombocytopenia
Authors: Philip L. Cimo
Journal: JAMA (1974)

<h3>To the Editor.—</h3> In their recent article (227:628, 1974), Kjeldsberg and Hershgold pointed out several conditions that may result in artifactual thrombocytopenia when platelet counts are made by automated methods. We recently saw a patient with still another type of pseudothrombocytopenia. She is 83 years old and was referred from another hospital because of rectal bleeding and "thrombocytopenia," with a platelet level of "10,000"/cu mm. There were no petechiae or ecchymoses, and the bleeding was localized to an anal fissure. The automated platelet count was 60,000/cu mm. However, the peripheral smear showed large masses of platelets that were clumped (Figure), and platelet clumping in an edetic acid-treated specimen made counting by phase microscopy unreliable. Platelet clumping also occurred in oxalated, citrated, and heparinized blood and was present to a slightly less degree in nonanticoagulated capillary blood obtained by fingerstick. The patient's serum did not contain platelet antibodies by the<sup>51</sup>
Abstract 1701: Soluble Receptor for Advanced Glycation End Products (RAGE) is a Prognostic Factor for Heart Failure
Authors: Yo Koyama, Yasuchika Takeishi, Takeshi Niizeki, Satoshi Suzuki, Tatsuro Kitahara, Toshiki Sasaki, Isao Kubota
Journal: Circulation (2007)

Background: It is known that oxidative stress is increased in patients with heart failure. Advanced glycation end products (AGE) are generated nonenzymatically by glycation and oxidation of proteins. We have recently reported that serum level AGE is an independent prognostic factor for heart failure. Receptor for AGE (RAGE) has a secretory isoform of the receptor protein, termed soluble RAGE. In the present study, we measured serum soluble RAGE levels in patients with heart failure. Methods: Serum soluble RAGE level was measured in 160 patients with heart failure and 40 control subjects. Patients were prospectively followed with endpoints of cardiac death or re-hospitalization. Results: Serum soluble RAGE level was increased with advancing NYHA functional class (figure 1 ). We determined the cut-off value of serum soluble RAGE level to predict cardiac events from ROC curve analysis as 1220 pg/ml (sensitivity 0.60, specificity 0.69). As shown in figure 2 , high serum soluble RAGE groups (&gt;1220 pg/ml) had a significantly lower cardiac event-free rate (P = 0.0004) than low serum soluble RAGE groups (≥ 1220 pg/ml). In the univariate Cox proportional hazard analysis, serum soluble RAGE, age, NYHA functional class, creatinine, B-type natriuretic peptide (BNP), left ventricular end-diastolic diameter (LVEDD) were significantly associated with cardiac events. In the multivariate Cox proportional hazard analysis, serum soluble RAGE and plasma BNP were independent risk factors for cardiac events (soluble RAGE: HR 2.22, 95% CI 1.08 - 4.53, P = 0.029; BNP: HR 2.86, 95% CI 1.11 - 7.37, P = 0.029). Conclusions: Serum soluble RAGE level is a novel independent prognostic factor for heart failure.
Graduation Year
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Childhood immunizations to be reconciled in 1995
Authors: C. Marwick
Journal: JAMA (1994)

STARTING next year, the voices of the various groups responsible for recommendations about the use of childhood vaccines will sing in unison. Since 1965, efforts have been made to try to ensure compatibility in the recommendations dealing with vaccine use made by public health and physicians' groups, but differences still arose. A number of groups routinely make such recommendations. They include the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention (CDC), the American Academy of Pediatrics (AAP), and the American Academy of Family Physicians (AAFP). Late last year, these groups gave a mandate to the CDC to develop a common immunization schedule for the administration of childhood vaccines. The mandate was backed by the CDC's working group on immunization, and an ad hoc group was created to draft such as a schedule. <h3>'An Unambiguous Message'</h3> "There are many reasons for providing an unambiguous message
Manuscripts Approved for JNCI, April 1 to May 1, 1969
Journal: JNCI Journal of the National Cancer Institute (1969)

Journal Article Manuscripts Approved for JNCI, April 1 to May 1, 1969 Get access JNCI: Journal of the National Cancer Institute, Volume 42, Issue 6, June 1969, Pages 1116–1117, https://doi.org/10.1093/jnci/42.6.1116-a Published: 01 June 1969
Progress towards achieving hepatitis C elimination in the country of Georgia, April 2015-October 2019
Authors: Tengiz Tsertsvadze, Amiran Gamkrelidze, Nikoloz Chkhartishvili, Akaki Abutidze, Lali Sharvadze, Vakhtang Kerashvili, Maia Butsashvili, David Metreveli, Lia Gvinjilia, Shaun Shadaker, Muazzam Nasrullah, Tamar Gabunia, Ekaterine Adamia, Stefan Zeuzem, Nezam Afdhal, Sanjeev Arora, Karla Thornton, Francisco Averhoff
Journal: Journal of Hepatology (2020)
"Organic Food"
Authors: Thomas H. Jukes
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Ms. Silverglade comments on question 5 in my article, which was "There is no difference in food value between food grown in poor, worn-out soil and food grown in rich soil," and she gives the example of iodine. However, iodine is not needed by plants. The term "poor, worn-out soil" refers to the adequacy of soil for plant growth. Such soils produce very low yields, or even no crops at all. On the other hand, soils that are deficient in iodine, cobalt, or selenium grow luxuriant crops that are nutritionally deficient for animals. But these soils are not "worn-out" in the agronomic sense. Other soils may contain levels of molybdenum that are so high that crops grown on such soils are toxic for animals. And, actually, plants do not need soil at all; they can be grown in water solutions of chemicals by the "hydroponic" system. Ms.
Research and patient care
Authors: H. H. Hecht
Journal: JAMA (1971)

There are two reasons why today we may wish to cast a brief glance both backward and forward: this is the 40th Frank Billings Lecture of the American Medical Association—an anniversary of sorts of lectures delivered annually by a succession of eminent American clinicians and investigators. The speaker today has no such claim, but he is the first to have been from an institution and department that owes its existence to Frank Billings and whose clinical facilities carry his name, the Billings Hospital. This is actually the oldest of 11 divisions of the University of Chicago Hospitals and Clinics complex on the campus of the university. It was named after Billings' uncle, Albert Merritt Billings, who was the founder and organizer of the Peoples Gas Company in Chicago. <h3>Frank Billings, an Architect of Early American Medical Education</h3> Frank Billings was born in 1854 in Highland, Iowa County, southwestern Wisconsin, the