tbuckley/cabot-search huggingface dataset:
DENTISTRY—OLD AND NEW
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ursodeoxycholic acid and/or ciprofibrate for treating patients with presumptive diagnosis of low phospholipid cholelithiasis, a clinical spectrum of progressive familial intrahepatic cholestasis type 3
Authors: Fernanda S. Linhares, Ana Cardoso, Debora Terrabuio, Michelle Harriz, Laura Guedes, Flair Jose Carrilho, Eduardo Luiz Rachid Cançado
Journal: Journal of Hepatology (2020)
Journal of Trauma, Baltimore
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Access to Health Care
Authors: Richard Amerling
Journal: Annals of Internal Medicine (1993)

Letters1 February 1993Access to Health CareRichard Amerling, MDRichard Amerling, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The long-awaited position paper [1] represents several years' work and the input of many ACP members. It is a comprehensive plan and makes valuable contributions to the current debate, particularly in the areas of insurance and tort reform. Topics not often discussed, such as financing of graduate medical education and basic health research, are welcome additions. The crucial section on controlling costs, however, contains serious flaws that undermine the overall plan.Heavy reliance is placed on central planning to allocate resources and on price controls to help keep costs within a global budget. These methods have failed ...References1. Scott HD, Shapiro HB. Universal insurance for American health care. A proposal of the American College of Physicians. Ann Intern Med. 1992; 117:511-9. Google Scholar2. Friedman M. Gammon's law applied to health care. The Wall Street Journal. May 1992. Google Scholar3. Rationing health care (Editorial). The Wall Street Journal. 11 February 1992. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1993Volume 118, Issue 3Page: 232-235KeywordsGraduate medical educationHealth careHealth care providersHealth care qualityMedical servicesMedicareResource based relative value scaleSub-specialty careSurgeonsTaxes Issue Published: 1 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PREVENTION OF ACUTE ARSPHENAMIN REACTION BY ANTIANAPHYLAXIS AND ATROPIN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allied health education and accreditation
Authors: J. T. Boberg
Journal: JAMA (1985)

<h3>COOPERATION AMONG THE HEALTH PROFESSIONS</h3> The term<i>allied health</i>describes a large cluster of health care personnel who fulfill necessary functions in the health provision system, including assisting, facilitating, and complementing the work of physicians and other medical specialists. For more than 50 years the American Medical Association (AMA) has participated extensively in activities to promote quality in the education of allied health personnel and in the accreditation review processes of allied health educational programs. In collaboration with the AMA, more than 48 allied health organizations and related medical specialty societies have developed educational standards for allied health professions that presently number 25 (Appendix IV, Table 1). Using these standards, the Committee on Allied Health Education and Accreditation (CAHEA) accredits more than 3,000 allied health educational programs, with more than 86,000 students and 39,000 graduates in 1983-1984 (Table), at nearly 1,800 institutions, including hospitals and clinics, junior and community colleges,
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1958)

COMMITTEE ON MATERNAL WELFAREPartial Premature Separation of the Placenta, with Amniotic-Fluid Infusion and HemorrhageA thirty-four-year-old gravida 2, para 1, was admitted in the forty-second week of pregnancy with vaginal bleeding after a normal prenatal course. Examination on the day before had shown the cervix to be effaced and dilated to admit 2 1/2 fingers, with the head in the pelvis. To avoid further postmaturity, induction of labor had been offered but was refused.The patient was in labor on admission. Within twenty minutes she was prepared for cesarean section; the blood was typed and crossmatched, the membranes were . . .
THE RECORD OF A BLOOD DONOR
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of Intensive Diabetes Treatment on Body Weight and Composition of Adults With Type 1 Diabetes in the Diabetes Control and Complications Trial
Authors: The Diabetes Control and Complications Trial Research Group
Journal: Diabetes Care (2001)

OBJECTIVE—To examine the differential effects of intensive and conventional diabetes therapy on weight gain and body composition in adults with type 1 diabetes. RESEARCH DESIGN AND METHODS—Between 1982 and 1989, 1,246 adults (aged 18–39 years) in the Diabetes Control and Complications Trial were randomly assigned to either conventional therapy (1–2 injections of insulin per day) or intensive therapy (multiple daily injections or continuous subcutaneous infusion with frequent blood-glucose testing). Height and weight were measured at baseline and at annual visits for an average of 6 years (range 3–9). Body composition was assessed cross-sectionally with bioelectrical impedance analysis during 1992, at which time waist and hip circumferences were measured. RESULTS—Intensively treated patients gained an average of 4.75 kg more than their conventionally treated counterparts (P &amp;lt; 0.0001). This represented excess increases in BMI of 1.5 kg/m2 among men and 1.8 kg/m2 among women. Growth-curve analysis showed that weight gain was most rapid during the first year of therapy. Intensive therapy patients were also more likely to become overweight (BMI ≥27.8 kg/m2 for men, ≥27.3 kg/m2 for women) or experience major weight gain (BMI increased ≥5 kg/m2). Waist-to-hip ratios, however, did not differ between treatment groups. Major weight gain was associated with higher percentages of body fat and greater fat-free mass, but among patients without major weight gain, those receiving intensive therapy had greater fat-free mass with no difference in adiposity. CONCLUSIONS—Intensive therapy for type 1 diabetes produces substantial excess weight gain compared with conventional therapy. However, the additional weight appears to include lean tissue as well as fat.
JAMA Pediatrics
Authors: Phil Fontanarosa, Annette Flanagin, Brenda Gregoline, Tracy Frey, Shannon Sparenga, Nicole Balin, Miriam Cintron, Paul Ruich, Diane Cannon, Connie Manno, Fred Marshall, Laura Copyreaders, Catherine Adamczyk, Stephanie Alden, Jan Beckmeyer, Mary Clavey, Paula Coerver-Connolly, Roya Glitman, Laura Khatiblou, Donna King, Caroline Thordsen, Wanda Assistant, Larry Bryant, Monica Mungle, Elaine Williams, Lenette Gardner-Gullens, Fanny Brown, Paul Frank, Peter Kim, Rachell Lozano, Michaela Mark, Kathryn Muskovich, Saulsberry Gale, Michael Berkwits, Michelle Kurzynski, Eric Butkus, Will English, Craig Mccaff Rey, Reuben Rios, Ronna Henry, Joshua Bird, Karen Bucher, Samantha Welker, David Song, Deputy Livingston, Thomas Cole, Marla Hall, Deanna Willis, Yolanda Davis, Joseph Thornton, Preeti Malani, Deanna Bellandi, Jim Periodical, Thomas Easley Vice, Brian Shields, Monica Smith, Jeff Ery, J Bonistalli Manager, Kathy Russell, Mirna Monal, Tim Melroy, Marketing Thornbury, Tricia Classifi, Thalia Moss, Mike Harvey, Susan Henning, Saskia Bolore, Gretchen Linder, Brian Mccartney, David Baum, Rebecca Haas, Christine Hearne, Irma Lara, Ron Thomas, Paul Gee, Matt Herron, Elizabeth Solaro, Geoff Rey Flick, Rick Bell, Lindsay Dawson, Michael Mcgraw, Romando Rossini, Stacy Staff, Millette Jackson-Bates, Karen Adams-Taylor, Karl Elvin, Jaye Mize, Sean O'donnell, Sue Managers, David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Colleen Kelly, Chris Meyer, Annemarie Neff, J Neff, Sean Ohlson, Phil O'leary, Bill Pedone, Susan Price, Denise Steinhauser, Joe Advertising, Production Services, Kim Boler, Rhonda Brown, Timothy Burke, Daniel Degroot, Jordynn Farrar, Euwanaha Joiner-Smith, Cindy Rendlen, Ellen Yoshihara, Circulation Services, Julie Burton, Dexter Golden, Erin Hinchcliff, Maria Nienhaus, Noemi Rivera, Geneine Van, Someren Composition, New Media, Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Teri Hutchison, Mary Kuranda, Joshua Lampinen, Nathan Mitre, Patricia Panek, La Son, Diggs Sledge, George Thomson Graphics, Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski, Proofreading Carol, Joy Farrell, Daniel James, Judith Literskis, Teresa Omiotek, Sam Wilder, James Madara, Bernard Hengesbaugh, Dimitri Christakis, Washington Joff, Ron Keren, Debra Palazzi, Suzanne Shuey, Samir Shah, Howard Bauchner, Frederick Rivara, Joyce Lee, Ann Arbor, Jay Berry, Cherrie Boyer, San Francisco, Maria Britto, John Campo, Aaron Carroll, Indiana Frank, Joseph Chaloupka, Mitchell Cohen, Sandra Friedman, Kathleen Colorado, Iowa Janz, Terry City, Joyce Klassen, Ann Lee, Michigan Arbor, Huckaby Michelle, Aaron Lewis, Shawn Milstone, Samir Rangel, Martha Shah, Jean-Claude Carel, Shabir Madhi, Ben Marais, Frank Oberklaid, Susan Sawyer, Joan-Carles Surís
Journal: JAMA Pediatrics (2015)
The authors reply
Authors: Y Merhi, A Arsenault, M Carrier, J G Latour
Journal: Cardiovascular Research (1994)

Journal Article The authors reply Get access Y Merhi, Y Merhi Institut de Cardiologie de Montréal, 500 E, rue Bélanger, Montéal, Québec, Canada HIT IC8 Search for other works by this author on: Oxford Academic PubMed Google Scholar A Arsenault, A Arsenault Institut de Cardiologie de Montréal, 500 E, rue Bélanger, Montéal, Québec, Canada HIT IC8 Search for other works by this author on: Oxford Academic PubMed Google Scholar M Carrier, M Carrier Institut de Cardiologie de Montréal, 500 E, rue Bélanger, Montéal, Québec, Canada HIT IC8 Search for other works by this author on: Oxford Academic PubMed Google Scholar J G Latour J G Latour Institut de Cardiologie de Montréal, 500 E, rue Bélanger, Montéal, Québec, Canada HIT IC8 Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 2, February 1994, Pages 285–286, https://doi.org/10.1093/cvr/28.2.285B Published: 01 February 1994
Involutional Osteoporosis
Authors: B. Lawrence Riggs, L. Joseph Melton
Journal: New England Journal of Medicine (1986)

OSTEOPOROSIS is an enormous public health problem, responsible for at least 1.2 million fractures in the United States each year. The sites of these fractures are the vertebrae in 538,000 cases, the hip in 227,000, the distal forearm (Colles' fracture) in 172,000, and other limb sites in 283,0001 (and Melton LJ, Riggs BL: unpublished data). One third of women over 65 will have vertebral fractures (Melton LJ, Riggs BL: unpublished data). By extreme old age, one of every three women and one of every six men will have had a hip fracture.2 This catastrophic type of fracture is fatal in . . .
Pneumotomy.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
U. K. qualifying examination in dermatology
Authors: M.W. Greaves
Journal: British Journal of Dermatology (1984)

Journal Article U. K. qualifying examination in dermatology Get access M.W. Greaves M.W. Greaves Institute of Dermatology, Lisle Street, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue 1, 1 July 1984, Page 126, https://doi.org/10.1111/j.1365-2133.1984.tb04032.x Published: 01 July 1984
Chronic Effects of Dietary Exposure to Amosite and Chrysotile Asbestos in Syrian Golden Hamsters
Authors: Ernest E. McConnell, Alan M. Shefner, John H. Rust, John A. Moore
Journal: Environmental Health Perspectives (1983)

Bioassays of amosite, short-range (SR), intermediate-range (IR) or intermediate-range chrysotile asbestos in combination with the intestinal carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) were conducted with male and female Syrian golden hamsters. Amosite and both forms of chrysotile asbestos were administered at a concentration of 1% in pelleted diet for the entire lifetime of the hamsters starting with mothers of the test animals. Group sizes varied from 125-254. There was no adverse effect on body weight gain or survival by either type of asbestos or by IR chrysotile asbestos in combination with DMH. A significant increase (p less than 0.05) in adrenal cortical tumors was observed in male hamsters exposed to SR and IR chrysotile asbestos and in females treated with IR chrysotile asbestos when compared to the pooled control groups. However, statistical significance (p less than 0.05) was lost when these dosed groups were compared with temporal control groups. Neither of the male or female amosite asbestos groups showed increased neoplasia in any tissue or organ compared to the control groups. The cocarcinogen studies using IR chrysotile asbestos and 1,2-dimethylhydrazine dihydrochloride were considered inadequate because there was no increase in intestinal neoplasia in the DMH group.
MONALDI'S TRANSPLEURAL ASPIRATION DRAINAGE OF TUBERCULOUS CAVITIES
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel effect of long-term digoxin therapy on heart rate variability in patient with chronic atrial fibrillation: A prospective study Anselma Intini, Naab Al-Saady, Yee Guan Yap, Johan Waktare, Mandy Graham, Bryan Mist, Marek Malik, A. John Camm. St. George's Hospital Medical School, London, United Kingdom
Journal: Journal of the American College of Cardiology (2001)
OC-042 The development of a novel endoscopic orthotopic tumour model for oesophageal cancer
Authors: V Sehgal, MA Butt, L Funnell, H Pye, S Khan, I Puccio, A Sultan, J Woodhams, S Mosse, B Draper, SP Patrick, T Kalber, R Hamoudi, M Rodriguez-Justo, M Pule, M Lythgoe, M Novelli, LB Lovat
Journal: Gut (2015)

<h3>Introduction</h3> The incidence of oesophageal adenocarcinoma (OAC) continues to rise rapidly. A clinically relevant animal model of OAC is needed to help study the effectiveness of novel therapeutic strategies for OAC. Current animal models have many limitations. Models that involve the injection of cells into the flanks of rodents do not replicate the native environment of OAC. Surgical models producing permanent biliary reflux that can lead to cancer are limited by the need for highly skilled surgical techniques, difficult reproducibility and significant morbidity to the animals involved. We describe a novel orthotopic tumour model for OAC. Our model is based upon the injection of tumour cells into the rodent oesophagus under direct endoscopic visualisation. <h3>Method</h3> Two human tumour cell lines were used – OAC (OE19) and colon adenocarcinoma (HT29). Both lines were stably transfected to express luciferase and maintained in 5% CO<sub>2 </sub>at 37<sup>0</sup>C. 6–8 week-old female nude athymic rats (RNU Rat) were used for all experiments. A high-resolution diagnostic endoscope was used to perform all endoscopic procedures. Animals were anaesthetised using Isoflurane with concomitant oxygen given. Under direct visualisation, OE19 or HT29 tumour cells were injected. Immediately after endoscopy, 1 ml of D-Luciferin (20 mg/ml) was injected i.p. to follow luciferase-expressing OE19/HT29 tumour implantation. After 15 min, rats were inserted into a whole body cooled charged-coupled device (CCD) camera Photon Imager system and images obtained. All animals had Bioluminescent imaging (BLI) and endoscopy performed regularly to look for evidence of tumour growth. <h3>Results</h3> Implanted tumour cells were detected immediately after injection using BLI. Weekly, non-invasive BLI and regular endoscopic observation detected successful orthotopic tumour growth (Figure 1). Histological tissue samples confirmed the presence of tumour ulcerating the overlying squamous mucosa and infiltrating into, and through, the muscularis propria. This mirrors closely the behaviour of a primary human OAC. <h3>Conclusion</h3> We have developed a novel, more clinically relevant, orthotopic tumour model for OAC. By utilising rodent gastroscopy, our model replicates the native environment in which OAC grows and provides an opportunity for us to better understand the natural history of OAC in a manner that confers considerably less morbidity to animals than current models allow. <h3>Disclosure of interest</h3> None Declared.