tbuckley/cabot-search huggingface dataset:
Temporal trends in cause-specific late mortality among five-year survivors of childhood cancer
Authors: G. T. Armstrong, Z. Pan, K. Ness, D. Srivastava, L. L. Robison
Journal: Journal of Clinical Oncology (2009)

10004 Background: Five-year survival rates for childhood cancer have increased over the past 4 decades, increasing the number of long-term survivors. Among 5-yr survivors, the impact of changes in therapy on cause-specific late mortality has not been thoroughly assessed. Methods: Late mortality was evaluated over 3 eras (1974–81, 1982–90, 1991–2000) in 26,643 5-year survivors diagnosed &lt;21 years of age from the SEER population-based registry. Cause-specific mortality was categorized as death from recurrence/progression of primary disease, external causes, and non-recurrence/non-external causes (Non-Recur/Ext) (i.e., deaths from health conditions including sequelae of cancer therapy). Results: All-cause and Recurrence mortality was significantly lower in more recent eras ( Table ). No significant improvement in late mortality attributable to Non-Recur/Ext causes was seen. Additionally, all-cause mortality was significantly lower in more recent eras for 5-year survivors of ALL, AML, Hodgkin, NHL, and CNS tumors, but not neuroblastoma and Ewing's Sarcoma where an increase in cumulative incidence of late mortality was seen in more recent eras. Significant improvement in late mortality from Recurrence by era was seen in most diagnostic groups. Conclusions: All-cause late mortality has improved with more recent eras, attributable to reduced rates of mortality from progression of primary disease (i.e., durable remission). Importantly, however, efforts to reduce the toxicity of more recent therapies have not produced detectable reduction in mortality attributable to other health conditions including sequelae of cancer therapy (non-Recur/Ext causes of death), which would include death from second malignancy, cardiac and pulmonary conditions. Worsening late mortality for 5-year survivors of neuroblastoma and Ewing's sarcoma may be due to improved use of salvage therapies that delay, but do not ultimately prevent death. [Table: see text] No significant financial relationships to disclose.
Postcoital contraception with diethylstilbestrol
Authors: L. K. Kuchera
Journal: JAMA (1971)

One thousand women of child bearing age were given, within 72 hours of sexual exposure, 25 mg of diethylstilbestrol twice daily for five days. No pregnancies resulted and there were no serious adverse reactions. It was emphasized to the patient that this was an emergency type of treatment and, should she have a continuing need for contraception, other means should be sought.
The Immediate Care of the Injured.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chromosome Aberrations in Workers Exposed to Arsenic
Authors: G. Beckman, L. Beckman, I. Nordenson
Journal: Environmental Health Perspectives (1977)

The occurrence of chromosome aberrations was studied in short-term cultured lymphocytes from nine workers exposed to arsenic at the Rönnskär smeltery in northern Sweden. In the smelter workers, 87 aberrations were found in 819 mitoses. The number of aberrations varied individually from 0 to 25 aberrations per 100 cells. In a control material 13 aberrations were found in 1012 mitoses. The frequency of chromosome aberrations was significantly increased among the smelter workers, but due to the simultaneous exposure to other agents the effect of arsenic per se can not be assessed with certainty.
Khirurgiia, Moscow
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
External beam radiation therapy (EBRT) use and safety with radium-223 dichloride (Ra-223) in patients (pts) with castration-resistant prostate cancer (CRPC) and symptomatic bone metastases (mets) from the ALSYMPCA trial
Authors: G. Paganelli, C. Rossetti, M. Aglietta, C. Messina, A. Versari, J.M. Michalski, J.M. O'Sullivan, C. Parker, J.E. Garcia-Vargas, A. Sartor, S.E. Finkelstein
Journal: Annals of Oncology (2015)
NIAID recommendations for treating HIV infection
Authors: C. D. Weiss
Journal: JAMA (1994)

<h3>In Reply.</h3> —I appreciate Dr Weiss' comments regarding the NIAID consensus panel's published recommendations dealing with antiretroviral therapy. Acquired immunodeficiency syndrome research is clearly in a period in which understanding of how the virus replicates and causes disease has not been translated effectively to the bedside. Treating this viral infection early certainly makes intuitive sense, especially since active replication occurs in the lymph nodes<sup>1</sup>(even though clinically silent) and nucleoside resistance develops more rapidly in later stages of the disease,<sup>2</sup>but data derived from clinical trials to date just do not show a significant survival benefit.<sup>3</sup> When to treat HIV infection and with which agent(s) is obviously a difficult clinical decision. However, the recent report by Lenderking et al<sup>4</sup>certainly underscores the potential downside with regard to quality of life when taking zidovudine. That is why the NIAID convened a group of thoughtful clinicians and statisticians
Oncogenes
Authors: Theodore G. Krontiris
Journal: New England Journal of Medicine (1995)

In the dozen years since the genetics of human cancer was first reviewed in these pages, we have achieved an understanding of the processes governing cell growth and differentiation that is quite sophisticated, but we still have far to go. For each cellular gene then implicated in the control of growth, at least a dozen more have joined the list. We have also added several concepts, entirely new and elemental, to our view of how cells enter the proliferative state and then leave it, either to undertake specialized tasks or to die. These advances have revolutionized the diagnosis and prognosis . . .
The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study
Authors: M. S. Lauer
Journal: JAMA (1991)

<h3>Objective.</h3> —To determine the relationship of varying degrees of obesity with left ventricular mass and geometry. <h3>Design.</h3> —Survey. <h3>Setting.</h3> —Population-based epidemiologic study. <h3>Participants and Methods.</h3> —M-mode echocardiograms, which were adequate for estimation of left ventricular mass, were obtained in 3922 healthy participants of the Framingham Heart Study. Measured height and weight were used to calculate body-mass index, a measure of obesity. <h3>Results.</h3> —Body-mass index was strongly correlated with left ventricular mass. After adjusting for age and blood pressure, body-mass index remained a strong independent predictor of left ventricular mass, left ventricular wall thickness, and left ventricular internal dimension (<i>P</i>&lt;.01 for all). Body-mass index was associated with prevalence of echocardiographic left ventricular hypertrophy, particularly in subjects with a body-mass index exceeding 30 kg/m<sup>2</sup>. <h3>Conclusions.</h3> —Obesity is significantly correlated with left ventricular mass, even after controlling for age and blood pressure. The increase in left ventricular mass associated with increasing adiposity reflects increases in both left ventricular wall thickness and left ventricular internal dimension. (<i>JAMA</i>. 1991;266:231-236)
Adolescents With Depression
Authors: Jeffrey A Bridge, David A Brent
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chirurgische Operationslehre für Studierende und Aerzte.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dextrostix method for determination of blood glucose levels. A statistical evaluation
Authors: J. A. Rock
Journal: JAMA (1966)

A chemically treated paper stick (Dextrostix) method of blood glucose estimation was compared to the alkaline potassium ferricyanide method in which an automated system (Auto Analyzer) of blood glucose estimation is used. Six medical technicians in a routine hospital laboratory performed the tests. Their instructions consisted solely of those accompanying the Dextrostix. Analysis of the data by the covariance technique suggests that, under the conditions of this study, the Dextrostix method has serious limitations. There was inconsistency, at least among technicians, in ability to discriminate shades of color, which rendered the Dextrostix method unsatisfactory for use as a mass-screening tool or as an alternate emergency laboratory procedure. It is also doubtful that the results of this method could be relied upon in the differential diagnosis of coma when the presence of hypoglycemia or hyperglycemia must be established with certainty.
Domiciliary Physiotherapy
Authors: R. Howard
Journal: BMJ (1966)

While many doctors may carry plasma and disposable drip sets, I usually keep these in my surgery and only put them in the car when I am likely to need them.Some of the items carried are seldom needed-for example, I have used the obstetric forceps four times in 13 years in home confinements.No doubt there is equipment missing from my list which one might assume should be there, but in practice I find the equipment is adequate.In my diagnostic bag are: stethoscope, sphygmomanometer, auriscope, ophthalmoscope, spatulae, torch, nasal speculum, Jobson Home ring and probe, patella hammer, foetal stethoscope,
Metabolic evaluation of nephrolithiasis in patients with medullary sponge kidney
Authors: M. O'Neill
Journal: JAMA (1981)

Seventeen patients with documented medullary sponge kidney and nephrolithiasis underwent metabolic evaluation. These patients constituted 3.6% of our stone-forming population. Fifteen (88%) of 17 were hypercalciuric. The most common abnormality was absorptive hypercalciuria, occurring in 59%. Only three patients (18%) had renal hypercalciuria. None of the patients had primary hyperparathyroidism. Hyperuricosuria occurred together with hypercalciuria in five patients. In two patients, the precise cause of hypercalciuria could not be determined, and in another two patients, no metabolic abnormality could be detected. Thus, the patients with medullary sponge kidney and renal stones had the same spectrum of metabolic abnormalities as the overall population of stone formers. While these patients may theoretically have a greater anatomic propensity to form stones because of their anatomic abnormality, they should be evaluated and treated appropriately for any metabolic defect. (<i>JAMA</i>1981;245:1233-1236)
Minireview: Epigenetic Changes in Ovarian Cancer
Authors: Curt Balch, Fang Fang, Daniela E. Matei, Tim H.-M. Huang, Kenneth P. Nephew
Journal: Endocrine Reviews (2009)

Epigenetic aberrations, including DNA methylation, histone modifications, and micro-RNA dysregulation, are now well established in the development and progression of ovarian cancer, and their gradual accumulation is associated with advancing disease stage and grade. Epigenetic aberrations are relatively stable, associated with distinct disease subtypes, and present in circulating serum, representing promising diagnostic, prognostic, and pharmacodynamic biomarkers. In contrast to DNA mutations and deletions, aberrant gene-repressive epigenetic modifications are potentially reversible by epigenetic therapies, including inhibitors of DNA methylation or histone-modifying enzymes. Although epigenetic monotherapies have not shown activity against solid tumors, including ovarian cancer, preclinical studies suggest they will be effective when used in combination with one another or with conventional chemotherapeutics, and combinatorial epigenetic therapy regiments are being examined in cancer clinical trials. A greater understanding of the role of epigenetics in ovarian neoplasia will provide for improved interventions against this devastating malignancy.
Abstract 4749: Aligned collagen is a prognostic signature for survival in human breast carcinoma
Authors: Matthew W. Conklin, Jens C. Eickoff, Kristin M. Riching, Carolyn A. Pehlke, Kevin W. Eliceiri, Paolo P. Provenzano, Friedl Andreas, Patricia J. Keely
Journal: Cancer Research (2011)

Abstract Evidence for the potent influence of stromal organization and function on invasion and metastasis of breast tumors is ever growing. Here we have performed a rigorous examination of the relationship of a tumor-associated collagen signature (TACS-3), to the long term survival rate of human patients. TACS-3 is characterized by bundles of straightened and aligned collagen fibers that are oriented perpendicular to the tumor boundary. An evaluation of TACS-3 was performed in biopsied tissue sections from 196 patients by second harmonic generation (SHG) imaging of the backscattered signal generated by collagen. Univariate analysis of a Cox proportional hazard model demonstrated that the presence of TACS-3 was associated with poor disease-specific and disease free survival, resulting in hazard ratios between 3.0-3.9. Furthermore, TACS-3 was confirmed to be an independent prognostic indicator regardless of tumor grade and size, ER or PR status, HER-2 status, node status, and tumor subtype. Interestingly, TACS-3 was positively correlated to expression of stromal syndecan-1, a receptor for several extracellular matrix proteins including collagens. Because of the strong statistical evidence for poor survival in patients with TACS, and since the assessment can be performed in routine histopathologic samples imaged via SHG or using picrosirius, we propose that quantifying collagen alignment is a viable, novel paradigm for the prediction of human breast cancer survival. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4749. doi:10.1158/1538-7445.AM2011-4749
LETTER FROM PARIS.
Authors: None A. B.
Journal: JAMA (1889)

Prof. Bouchard's Mixed Method of Treating Typhoid Fever—The Pernicious Influence of Artificial Feeding on Young Children—Dr. Du Castel on the Antiseptic Treatment of Blenorrhagia—Injections of Carbolic Acid in the Treatment of Carbuncle—Soap as an Antidote for Carbolic Acid. Professor Bouchard has a mixed method of treating typhoid which consists in the application, within certain limits, of antithermic and general antisepsy. General antisepsy is obtained by mercurial preparations. At the onset only of the fever, during four days, the patient takes 20 pills of 2 centigrams of calomel per day. Balneotherapy is prescribed as follows: As soon as the rectal temperature passes 40° C., cold baths, to the number of eight in the twenty-four hours, should be given. These baths should maintain the body at a temperature of from 37° C. to 37.5° C. If these baths do not sufficiently lower the temperature, the sulphate of quinine should be prescribed. This
The poor quality of early evaluations of magnetic resonance imaging
Authors: L. S. Cooper
Journal: JAMA (1988)

To study the quality of early research on the clinical efficacy of diagnostic imaging with magnetic resonance, we assessed 54 evaluations published in the first four years after introduction of this modality using ten commonly accepted criteria of research methodology. The terms<i>sensitivity, specificity, false-positive</i>or<i>false-negative, accuracy</i>, and<i>predictive values</i>were used infrequently. Nineteen percent of the evaluations used three terms appropriately, 48% used one or two terms, and 33% used none. Data were presented appropriately for one or more of the five terms in 59% of evaluations. A "gold standard" comparison with the results of an independent procedure, such as surgical or autopsy findings, was presented in 22% of evaluations. Results of another imaging procedure were described in 63% of evaluations. Only one evaluation clearly described a prospective study design, although 11 evaluations apparently were planned in advance. Not one evaluation contained an appropriate statistical analysis of the distributions of quantitative readings, "blinded" image readers to diagnosis or other test results, measured observer error, or randomized the order of magnetic resonance imaging and other imaging procedures. We conclude that health care professionals paying for expensive innovative diagnostic technology should demand better research on diagnostic efficacy. (<i>JAMA</i>1988;259:3277-3280)
Leads from the MMWR. Risks associated with human parvovirus B19 infection
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Are there any benefits of using an inlay graft in the treatment of primary hypospadias in children? A systematic review and metanalysis
Authors: M.S. Silay, L. ‘t Hoen, N. Bhatt, J. Quaedackers, G. Bogaert, H.S. Dogan, R.J. Nijman, Y. Rawashdeh, R. Stein, S. Tekgul, C. Radmayr
Journal: European Urology (2021)
HIV/AIDS Among American Indians and Alaskan Natives—United States, 1981-1997
Journal: JAMA (1998)

A total of 641,086 cases of acquired immunodeficiency syndrome (AIDS) had been reported to CDC through December 1997. Of these, 1783 (0.3%) occurred in American Indians and Alaskan Natives (AI/ANs). AI/ANs represent <1% of the total U.S. population (272 million persons) and are characteristically diverse, comprising many tribes-of which 557 are federally recognized. Each tribe has its own traditions and culture. This report 1) describes characteristics of AI/ANs with AIDS reported to CDC through 1997; 2) summarizes trends in AIDS incidence among AI/ANs from 1986 to 1996; and 3) for the 25 states in which surveillance was conducted during 1994-1997 for human immunodeficiency virus (HIV) and AIDS, compares the characteristics of AI/ANs who had reported HIV infection (without AIDS) with those of AI/ANs who had AIDS. These findings, which highlight the characteristics of AI/ANs for whom HIV or AIDS had been diagnosed, can assist in the development of targeted prevention strategies.