tbuckley/cabot-search huggingface dataset:
Error in Methods, Results, and Table
Journal: JAMA Network Open (2020)

Ryan W. Stidham, MD, MS; Wenshuo Liu, PhD; Shrinivas Bishu, MD; Michael D. Rice, MD; Peter D. R. Higgins, MD, PhD; Ji Zhu, PhD, MSc; Brahmajee K. Nallamothu, MD, MPH; Akbar K. Waljee, MD, MSc
Journal of Histochem and Cytochem, Baltimore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Medical Directory of New York, New Jersey and Connecticut.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A single institution experience with droplet digital polymerase chain reaction (dd-PCR) liquid biopsy (LB) for therapeutic decision in advanced solid tumors.
Authors: Andre Marcio Murad, Juliana Garcia Carneiro, José Claudio Casali-da-Rocha
Journal: Journal of Clinical Oncology (2021)

3038 Background: Droplet digital polymerase chain reaction (ddPCR) is a promising method for analyzing minor amounts of cell-free circulating free nucleic acid (DNA and RNA) due to its high sensitivity, low cost, and fast reading, since it dispenses bioinformatics, making it an appropriate alternative to new generation sequencing (NGS) for the detection of biomarkers to guide molecularly targeted cancer therapy. The assay covers main actionable hotspot alterations across many actionable genes: EGFR(mutations), ALK (fusion, mutations), ROS1(fusion), BRAF(mutations), KRAS (mutations), NRAS(mutations), PIK3CA (mutations), ERBB2(CNV- copy number variation), ESR1(mutations), KIT(CNV) and PDGFRA(CNV). Therefore, our genes can be used in panels, both in therapeutically applied genotyping and in detecting molecular responses as well as in secondary resistance to tumors such as NSCLC, breast, cervix. rectal, GIST, melanoma and pancreas. Methods: dd-PCR was performed using the QX200 system (BIO-RAD, Hercules). The extraction of DNA and RNA was done using the magnetic beads technique of Thermofisher's MagMAX Kit. All samples were tested in duplicate. Up to now, 108 metastatic cancer patients were tested: NSCLC - 28 (26%), breast - 22 (20%), colorectal - 22(20%), melanoma - 18(17%), pancreas - 8(7%), ovarian - 6(6%), salivary glands - 2 (4%) and GIST 2(4%). Results: Significant genomic alterations were detected in 38(35%) patients: 10 (9%) mutations in the KRAS G12V gene (all in colorectal cancer), 10 (9%) ERBB2 amplification (breast cancer), 4 (3.65%) EGFR L858R mutations (NSCLC), 4 (3.5%) EGFR del19 mutations (NSLC), 4 (3.5%) EGFR T790M mutations (NSCLC), 4 (3.5%) BRAF-V600E mutations (colon and melanoma), 2 (1.8%) ALK-EML4 fusion (NSCLC). The MAF (Mutant Allele Fraction) ranged from 0.9% to 24%. In all cases, the results were decisive for the indication or change of a targeted therapy. Median turnaround time was 36 hours and the average cost of the panels was around 500 USD (median of 4 genes per panel). Conclusions: Our results suggest that dd-PCR is a highly sensitive method and could be used for a routine laboratory detection of the important genomic variations to determine the targeted therapy in patients with varied advanced solid tumors.
Environmental and Toxicological Planning in Polymer Production and Disposal
Authors: George J. Levinskas
Journal: Environmental Health Perspectives (1975)

There is neither a prescribed format nor a rigid sequence of testing to follow for the assessment of health and environmental effects of chemicals. Conventional animal toxicity tests plus medical surveillance and monitoring of exposed human populations will provide knowledge of the biological effects of chemicals and assurance that they can be handled safely. Useful information also can be derived from other test procedures. These include extraction studies to measure the amounts of additives which can leach from polymers, toxicity tests using aquatic organisms and birds, and determination of the biodegradability of materials and their potential for accumulation and magnification in biological systems. Current concern over pyrolysis products of polymers points up the need for defining the variables involved and development of test procedures by which meaningful evaluations of potential health hazards can be made.
Predictive role of mismatch repair deficiency (MMR-D) in patients receiving first-line fluoropyrimidine and platinum (F-P) doublet chemotherapy for metastatic and locally advanced unresectable gastric cancers (GC).
Authors: Heejung Chae, Min-hee Ryu, Young Soo Park, Yangsoon Park, MeeSun Moon, Yoon-Koo Kang
Journal: Journal of Clinical Oncology (2020)

444 Background: Although adjuvant chemotherapy has been known to have a detrimental effect on MMR-D patients (pts) with resectable GC, it is unclear whether palliative chemotherapy for advanced GC would also adversely affect the survival outcome of MMR-D pts. Immune-checkpoint inhibitor (ICI) monotherapy was approved as a standard treatment for ≥ 3rd line of advanced GC and also showed a remarkable efficacy in MMR-D pts regardless of line of therapy. ICI is now being investigated in combination with 1st-line cytotoxic chemotherapy. Hence, we aim to evaluate the prognostic impact of MMR on cytotoxic chemotherapy in advanced GC. Methods: We reviewed our prospective database to identify pts with initally metastatic, recurrent and locally advanced unresectable GC who received F-P doublet from 2015 to 2018. MMR was assessed by immunohistochemistry with previously-collected tumor tissue and correlated with clinical characteristics and survival outcomes. Results: Out of 892 pts identified from the database, 543 underwent MMR test [382 initally metastatic (70.3%); 127 recurrent (23.3%); 32 locally advanced unresectable (6.3%)]. Median age was 58 years (range, 24–86) with male comprising 64.0%. MMR-D was found in 4.4% (n = 24) and associated with age ≥ 65 (50% vs 29.9%; P = 0.037), antrum-origin (62.5% vs 34.1%, P = 0.004) and well/moderately-differentiated histology (41.7% vs 25.8%, P = 0.110). According to our prognostic model (Koo DH et al, 2011), MMR-D pts were less likely to be classified into poor-risk group (4.2% vs 16.8%, P = 0.102). In good-risk group, MMR-D pts had significantly shorter PFS (6.0 vs 9.0 months, P = 0.045) and OS (10.1 vs 20.9 months, P = 0.047), while pts in moderate and poor risk group showed no difference in survival depending on MMR status. Conclusions: MMR-D GC showed significantly shorter PFS and OS on F-P doublet in good-risk pts and further investigation is needed to determine underlying molecular mechanisms. With the negative impact of MMR-D on the effect of cytotoxic chemotherapy, exclusion of MMR-D pts should be considered in future trials of ICI and cytotoxic chemothrapy combination.
East Asian Medicine
Authors: Ted J. Kaptchuk
Journal: Annals of Internal Medicine (2002)

Letters15 October 2002East Asian MedicineTed J. Kaptchuk, OMDTed J. Kaptchuk, OMDHarvard Medical School; Boston, MA 02215Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-8-200210150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Barnes' comment on the need for a sensitive bilingual encounter between distinct medical systems is greatly appreciated. Indeed, knowledge of other medical systems necessarily encourages self-awareness and is an antidote to arrogance. I find myself so much in agreement with Dr. Barnes that I wonder whether her metaphor of language and “translation” may not be radical enough. The difference between traditional East Asian concepts of medicine and biomedicine extends beyond linguistic issues to the philosophical foundations of their epistemology (1). Chinese medicine relies on the veracity of the senses, the person-centered experience either as reported by the ...References1. Kaptchuk TJ. The Web That Has No Weaver: Understanding Chinese Medicine. Chicago: Contemporary (McGraw-Hill); 2000. Google Scholar2. Unshuld PU. Medicine in China: A History of Pharmaceutics. Berkeley, CA: Univ of California Pr; 1986. Google Scholar3. Hsu E. Innovations in acumoxa: acupuncture analgesia, scalp and ear acupuncture in the People's Republic of China. Soc Sci Med. 1996;42:421-30. [PMID: 8658235] CrossrefMedlineGoogle Scholar4. Li CP. Chinese Herbal Medicine. Washington, DC: John E. Fogarty International Center; 1974. Google Scholar5. Marshall E. Drugs. Reinventing an ancient cure for malaria. Science. 2000;290:437-9. [PMID: 11183758] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Ted J. Kaptchuk, OMDAffiliations: Harvard Medical School; Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAcupuncture: Theory, Efficacy, and Practice Ted J. Kaptchuk East Asian Medicine Linda L. Barnes Metrics Cited byAcupunctureAcupunctureAmerican Acupuncture and Efficacy: Meanings and Their Points of Insertion 15 October 2002Volume 137, Issue 8Page: 703KeywordsAcupunctureAntidotesDrugsMalariaTraditional Chinese medicineTraditional medicine ePublished: 15 October 2002 Issue Published: 15 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SURG-19. IMPACT OF INTRAOPERATIVE MAGNETIC RESONANCE IMAGING ON THE EXTENT OF RESECTION AND FUNCTIONAL OUTCOME IN AWAKE SURGERY FOR ELOQUENT GLIOMAS – A SINGLE CENTER RETROSPECTIVE STUDY
Authors: Christine Jungk, Moritz Scherer, Huy Philip DaoTrong, Christoph Schramm, Stefan Haehnel, Christel Herold-Mende, Andreas Unterberg
Journal: Neuro-Oncology (2018)

Maximizing the extent of resection (EOR) while preserving functional integrity is a mainstay of glioma surgery. Intraoperative MRI (iMRI) helps to augment the EOR. However, in eloquently located gliomas the significance of iMRI is controversial since the EOR is limited by functional rather than image-based boundaries. Thus, we sought to determine the impact of iMRI in our institutional series of awake glioma resections within or adjacent to eloquent (language, motor, sensory) areas since the implementation of a 1.5 Tesla iMRI in 2009. Tumor- and procedure-related data and functional outcome were assessed through medical charts review. The EOR was determined volumetrically on pre-, intra- and postoperative T1 contrast-enhanced (CE) and FLAIR MR images. 86 of 104 awake surgeries (83%) were performed under iMRI-guidance with concurrent language (n=72) and/or motor (n=50) mapping. iMRI was done when functional boundaries were reached (n=26), for resection control (n=53) or for other reasons (n=7). Additional resection after iMRI (AR) was performed in 63 cases (73%); otherwise resection was terminated because the targeted EOR or functional boundaries were reached. New or deteriorated neurological deficits occurred in 20 patients prior and 15 patients post iMRI; however, all but 3 resolved within 6 months. Median EOR significantly increased after AR from 92.6% to 98.4% (5.8%; p<0.0001) in CE tumors and from 64.5% to 85.8% (21.3%; p<0.0001) in non-enhancing tumors. Remarkably, the reason to perform iMRI (resection control or functional limitations), did not affect the frequency of AR, deficits acquired post iMRI or the increase in EOR after AR. In conclusion, iMRI is a valuable adjunct to maximize the EOR in awake glioma resections without increasing the risk for functional impairment, particularly in non-enhancing tumors. Importantly, iMRI contributes to a maximized EOR even in cases where the resection had to be stopped because functional boundaries were reached.
Red Cell Lead, Whole Blood Lead, and Red Cell Enzymes
Authors: Carol R. Angle, Matilda S. McIntire
Journal: Environmental Health Perspectives (1974)

Simultaneous assay of blood lead (Pb-B) and red cell lead (Pb-Rbc) in 123 samples from 104 urban and suburban students, ages 10-18, shows the ratio of concentration (Pb-Rbc)/(Pb-B) to increase as the hematocrit decreases.On direct assay in 40 sam- ples, plasma lead (Pb-P) was fixed in a narrow range.In 28 students with Pb-Rbc >40 ug/100 ml, the mean red cell 2,3-diphosphoglycerate (2,3-DPG) was 6.05 0.28 (±S.E.), significantly higher (P<.025) than the 5.25±0.18 of 51 students with Pb- Rbc<40 ug/100 ml, although hemoglobin values were comparable (13.83 ±0.31 versus 13.55 0.20).Analysis of the individual population groups showed this correlation of Pb-Rbc with 2,3-DPG to be primarily related to the intercorrelation of each parameter with hemoglobin.Rbc membrane Na/K ATPase, as per cent of total membrane ATPase, had a median value of 60% in 48 subjects.Na/K ATPase below 60% was found in 10 (77%) of the 13 students with Pb-Rbc240 ;&g/100 ml, but in only 14 of the 35 with Pb-Rbc<40 lAg/100 ml (XI = 5.1, df = 1, P<0.05).Correlation of significant enzyme changes with Pb-Rbc, but not with Pb-B in the normal urban range of Pb-B<35 ug/100 ml suggests Pb-Rbc, increased in anemia, to be a critical factor in the hematotoxicity of lead.
Benefits of immediate versus delayed palliative care to informal family caregivers of persons with advanced cancer: Outcomes from the ENABLE III randomized clinical trial.
Authors: J Nicholas Dionne-Odom, Andres Azuero, Kathleen Lyons, Zhongze Li, Tor Tosteson, Zhigang Li, Jay Hull, Jennifer Frost, Mark Hegel, Konstantin H. Dragnev, Imatullah Akyar, Marie Bakitas
Journal: Journal of Clinical Oncology (2014)

LBA9513 Background: Family caregivers of individuals with advanced cancer experience significant burden and diminished QOL; few interventions have been found to reduce these outcomes. Methods: Randomized clinical trial conducted from 10/11/2010 to 9/5/2013 of immediate versus delayed (initiated 12 weeks after randomization) entry patients (n=207) and caregivers (n=122) into ENABLE (Educate, Nurture, Advise, Before Life Ends), a phone-based concurrent oncology palliative care intervention. QOL (Caregiver Quality of Life-Cancer, lower scores=better QOL), depression (Center for Epidemiological Study-Depression) and burden (Montgomery Borgatta Caregiver Burden Scale; subjective burden [SB], objective burden [OB]; demand burden [DB]) measures were collected at baseline, 6, 12, 18, and 24 weeks, and every 12 weeks until patient death or study completion. Results: Estimated treatment effects (immediate minus delayed) for caregivers from randomization to 12 weeks were (mean [SE]): -3.1 [2.3] for QOL (P=.17), -4.1 [1.3] for depression (P=.003), -1.0 [0.4] for SB (P=.02), 0.3 [0.6] for OB (P=.60), and -0.5 [0.6] for DB (P=.39). Estimated treatment effects (immediate minus delayed) from intervention initiation to 12 weeks were (mean [SE]): -6.4 [3.4] for QOL (P=.06), -7.4 [2] for depression (P<.001), -1.0 [0.6] for SB (P=.08), -0.6 [0.7] for OB (P=.44), and -0.5 [0.8] for DB (P=.50). Estimated treatment effects (immediate minus delayed) measured backwards from the time of patient’s death were (mean [SE]): of -4.9 [2.6] for QOL (P=.07), -3.8 [1.5] for depression (P=.02), -1.1 [0.4] for SB (P=.01), -0.6 [0.6] for OB (P=.26), and -0.7 [0.6] for DB (P=.22). Conclusions: Caregivers in the immediate group had lower depression, SB, and trends towards better QOL in comparisons up to 12 weeks, following initiation of the intervention in both groups, and in the terminal decline analysis. These results suggest that concurrent oncology palliative care should be initiated as early as possible to maximize benefit to caregivers. Clinical trial information: NCT01245621.
Abstract 1431: In vivo CRISPR/Cas9 screen of adoptively transferred T cells reveals novel mediators of T cell exhaustion and immunosuppression
Authors: Jin K. Park, David A. Canner, Rebecca Herbst, Amy Li, Olivia C. Smith, Aviv Regev, Tyler E. Jacks
Journal: Cancer Research (2019)

Abstract Adoptive cell therapy (ACT) is a form of cancer immunotherapy in which patients receive an infusion of a polyclonal population of autologous CD8+ T cells that can be genetically modified ex vivo to optimize their function against the tumor. Although clinical responses to ACT have been successful for a very limited number of indications (most notably pediatric leukemias), its efficacy in solid tumors is very limited, likely due to immunosuppressive mechanisms constraining efficacy. To date, there have not been systematic approaches to discover novel T cell-intrinsic mediators of exhaustion in the context of ACT. Here, we describe a systematic and unbiased approach to uncover novel regulators of exhaustion in adoptively transferred CD8+ T cells. We report the results of longitudinal RNA sequencing of adoptively transferred cells at various time points post-transfer, revealing the complex transcriptional changes that transferred cells undergo. In addition, we report the results of an in vivo CRISPR/Cas9-mediated genetic screen. Taken together, this integrated approach of longitudinal RNAseq and CRISPR/Cas9 screening has yielded mediators previously uncharacterized in T cells that can be targeted to drastically improve functionality, cytotoxicity, and persistence in the tumor microenvironment. Note: This abstract was not presented at the meeting. Citation Format: Jin K. Park, David A. Canner, Rebecca Herbst, Amy Li, Olivia C. Smith, Aviv Regev, Tyler E. Jacks. In vivo CRISPR/Cas9 screen of adoptively transferred T cells reveals novel mediators of T cell exhaustion and immunosuppression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1431.
On oracles, education, and the public weal
Authors: N. E. Davies
Journal: JAMA (1976)

DELPHI, the seat of the most famous oracle of ancient Greece, was located on a rocky declivity on the southern side of Parnassus. There, questions were asked about future events, and answers were received that were always equivocal and obscure. To assure an answer, questions were accompanied by gifts, often magnificent offerings whose value was in direct proportion to the importance of the question. The answers were given as murmurings by the oracle, and the murmurings were interpreted by nameless priests, undoubtedly contemporary bureaucrats, whose answers tended to uphold and lend support to the religious, political, and civil structures of the time. <h3>The Delphi Method</h3> Man has always wanted to predict the future. Toward this end, the Rand Corporation, during the last decade, devised an interesting experimental device that under certain circumstances may be successful in doing just that.<sup>1</sup>This device is called the Delphi method. Using this method,
Boards of Examiners in the Basic Sciences
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On things not being what they seem
Journal: BMJ (2002)

How to manage a genital prolapseHalf of all parous women are estimated to lose pelvic floor support, resulting in some degree of genital prolapse, and 10-20% of these women seek medical care.In the United Kingdom genital prolapse accounts for 20% of women on the waiting list for major gynaecological surgery.In this week's clinical review Thankar and colleagues (p 1258) review the management of genital prolapse in primary care, including pelvic floor exercises and pessaries, and describe the surgical options available.
ABSTRACTS
Authors: H Spaet, T Bothwell, T Brittigham, I Chanarin, J Chatterjea, India Amoz, I Chernoff, Tenn Pietro Denicola, Ludvik Donner, A Erslev, Philadelphia Fudenberg, San Francisco, Katsuhiro Fukutake, Robert Goldstein, Ira Green, F Lionetti, N Fortier
Journal: Blood (1964)