tbuckley/cabot-search huggingface dataset:
Intellectual changes associated with levodopa therapy
Authors: M. J. Meier
Journal: JAMA (1970)

<h3>To the Editor:—</h3> In addition to changes in motor behavior associated with levodopa (L-Dopa) therapy in Parkinson's disease,<sup>1</sup>we have been monitoring the intellectual functioning of these patients by means of the Wechsler adult intelligence scale (WAIS)<sup>2</sup>and the Porteus maze test.<sup>3</sup> Although previous preliminary investigations<sup>4</sup>did not reveal measurable changes in intellectual functioning after L-Dopa therapy (Boshes B., et al:<i>Trans Amer Neurol Assoc</i><b>94</b>:229, 1969), it seemed appropriate to examine possible intellectual effects of the drug in a larger series of patients. The WAIS and Porteus procedures were administered while the patient was being treated with conventional medication and again after six weeks of L-Dopa therapy. The extension series of the Porteus was utilized in the second testing to reduce practice effects. The WAIS subtest scores were subdivided into factor scores or deviation quotients which were derived from earlier factor analyses of this
Family Medicine
Authors: Marjorie A. Bowman
Journal: JAMA (1993)

Many advances have increased opportunities for family physicians to help their patients. Of the literally hundreds of reported studies that might influence a family physician's practice, areas with important new information include the preventive use of exercise, prevention of disease in children, and prevention of domestic violence and heart disease. The importance of the family physician's role has also been verified in recent research. Regular, vigorous exercise was shown to be associated with a lower risk of development of non—insulin-dependent diabetes mellitus in male physicians aged 40 to 84 years (mean age, 53 years),<sup>1</sup>and this finding probably could be generalized to other patient populations. The risk was shown to be dose dependent, with relative risks ranging from 1.0 for those who exercised once a week to 0.58 for those who exercised five or more times weekly. An even stronger preventive effect was shown for exercise in the rate
Abstract 485: The NCI Mouse Repository: Cancer models and microRNA ES cell resource
Authors: Parirokh Awasthi, Debra Fitzgerald, Stephen Jones
Journal: Cancer Research (2020)

Abstract The NCI Mouse Repository, located at the Frederick National Laboratory for Cancer Research (FNLCR), Frederick, Maryland, is an NCI-funded resource of approximately 150 genetically-engineered mouse cancer models and associated strains, including mice bearing conditional and point-mutant alleles in cancer-related genes. In addition, the Repository houses a unique collection of over 1500 different mouse ES cell clones bearing conditionally-activated miRNA transgenes to facilitate in vivo exploration of miRNA functions. The NCI Mouse Repository makes strains and mESCs available to all members of the scientific community (academic, non-profit, and commercial). The mouse models and ES cell clones are cryo-archived and distributed as frozen germplasm or cells. Requests may be placed through the NCI Mouse Repository website (https://ncifrederick.cancer.gov/Lasp/MouseRepository/Default.aspx). In addition to the request form, this website includes detailed description for each strain accepted into the Repository and the associated publications provided by the donating scientist. The miR-harboring ESCs, originally generated at the Cold Spring Harbor Laboratories for the NCI, are described in full detail and include validation data for each miRNA ES cell clone. These resources are available for nominal cost to NCI, NIH, and other US government-funded investigators, as well as to Investigators at non-profit organizations. Citation Format: Parirokh Awasthi, Debra Fitzgerald, Stephen Jones. The NCI Mouse Repository: Cancer models and microRNA ES cell resource [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 485.
Infectious Diseases: A Modern Treatise on Infectious Processes
Authors: Jerry D. Smilack
Journal: JAMA (1990)

<h3>Principles and Practice of Infectious Diseases,</h3> edited by Gerald L. Mandell, R. Gordon Douglas, Jr, and John E. Bennett, 3rd ed, 2340 pp, with illus, $185, ISBN 0-443-08686-9, New York, NY, Churchill Livingstone, 1990. The nearly simultaneous release of these two major texts makes a side-by-side comparison almost inevitable. My work as an infectious diseases consultant has often led me to refer to each—looking for reviews of particular types of infection, as well as seeking the latest recommendations on diagnostic and therapeutic approaches. Hoeprich and Jordan's<i>Infectious Diseases</i>is now in its fourth edition, a fact that testifies to its wide acceptance since its original publication 18 years ago. Unlike many others, editors of infectious diseases texts have a fundamental decision to make at the outset: whether to focus primarily on specific microorganisms as etiologic agents and secondarily on the diseases they produce (eg, the pneumococcus and pneumonia in
THE POSTOFFICE DEPARTMENT AND MEDICAL LEGISLATION.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis
Authors: Geert van Loo, Mozes Sze, Nadia Bougarne, Jelle Praet, Conor McGuire, Andrea Ullrich, Guy Haegeman, Marco Prinz, Rudi Beyaert, Karolien De Bosscher
Journal: Endocrine Reviews (2009)

Abstract Compound A (CpdA), a plant-derived phenyl aziridine precursor, was recently characterized as a fully dissociated nonsteroidal antiinflammatory agent, acting via activation of the glucocorticoid receptor, thereby down-modulating nuclear factor-κB-mediated transactivation, but not supporting glucocorticoid response element-driven gene expression. The present study demonstrates the effectiveness of CpdA in inhibiting the disease progress in experimental autoimmune encephalomyelitis (EAE), a well-characterized animal model of multiple sclerosis. CpdA treatment of mice, both early and at the peak of the disease, markedly suppressed the clinical symptoms of EAE induced by myelin oligodendrocyte glycoprotein peptide immunization. Attenuation of the clinical symptoms of EAE by CpdA was accompanied by reduced leukocyte infiltration in the spinal cord, reduced expression of inflammatory cytokines and chemokines, and reduced neuronal damage and demyelination. In vivo CpdA therapy suppressed the encephalogenicity of myelin oligodendrocyte glycoprotein peptide-specific T cells. Moreover, CpdA was able to inhibit TNF- and lipopolysaccharide-induced nuclear factor-κB activation in primary microglial cells in vitro, in a differential mechanistic manner as compared with dexamethasone. Finally, in EAE mice the therapeutic effect of CpdA, in contrast to that of dexamethasone, occurred in the absence of hyperinsulinemia and in the absence of a suppressive effect on the hypothalamic-pituitary-adrenal axis. Based on these results, we propose CpdA as a compound with promising antiinflammatory characteristics useful for therapeutic intervention in multiple sclerosis and other neuroinflammatory diseases.
Abstract 5107: Putative biomarkers for tumor sample purity prediction based on gene expression data
Authors: Yuanyuan Li
Journal: Cancer Research (2019)

Abstract Tumor purity is the percent of cancer cells present in a sample of tumor tissue. The non-cancerous cells (immune cells, fibroblasts, etc.) have an important role in tumor biology. We applied a supervised machine learning method, XGBoost, to data from 33 TCGA tumor types to predict tumor purity using RNA-seq gene expression data. Across the 33 tumor types, the median correlation between observed and predicted tumor-purity ranged from 0.75 to 0.87 with small root mean square errors, suggesting that tumor purity can be accurately predicted using expression data. We further confirmed that a ten-gene set (CSF2RB, RHOH, C1S, CCDC69, CCL22, CYTIP, POU2AF1, FGR, CCL21, and IL7R) whose expression levels alone were predictive of tumor purity regardless of tumor type. We tested the predicative power of the ten-gene set on an independent dataset that was not from TCGA and showed that the expression levels of the ten genes can accurately predict the cancer cell proportions in those independent samples. The correlation coefficient between the predicted and experimentally obtained tumor purity was 0.88. Our analyses suggested that the ten-gene set may serve as a biomarker for tumor purity prediction using gene expression data. Citation Format: Yuanyuan Li. Putative biomarkers for tumor sample purity prediction based on gene expression data [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5107.
NEURASTHENIA.
Authors: J. THOMAS WRIGHT
Journal: JAMA (1905)

patient, and concerning the latter the amount of hemo- globin present and such other factors as may influence the freezing point.When cryoscopy is applied in a differential sense to the separate urines, it becomes of great value in deter- mining the amount of work done by each kidney.The use of phloridzin as a test of renal activity was first employed by Klemperer.As is well known, phloridzin, when injected subcutaneously, produces a tem- porary glycosuria, and the amount of sugar eliminated by each kidney depends on the amount of active paren- chyma possessed by the kidney.Ureteral catheterization or segregation, therefore, must be used in connection with the phloridzin test, for this test becomes of value only when the amount of sugar contained in the separate urines is compared.When used in this manner the test has some value.The methylene blue test is purposely omitted, as its value is probably not great.The value of the z-ray in the diag- nosis of renal and ureteral calculi has become firmly established and need only be mentioned here.In conclusion, then, the newer aids to diagnosis in diseases of the urinary tract may be arranged in the following order, according to their value:1.The cystoscope. 2. Ureteral catheterization or segregation with com- parative analyses of the separate urines.3. The s-ray.4. The phloridzin test. 5. Comparative cryoscopy of the separate urines. 6. Cryoscopy of the blood with the necessary correc- tions made.NEURASTHENIA.
Respiratory disability in coal miners
Authors: D. Elisburg
Journal: JAMA (1980)

<h3>In Reply.—</h3> In response to Mr Elisburg, our sample may not have been representative, but our data are in accord with previous studies in working coal miners whose ventilatory capacity closely resembled that of the normal population, except when complicated CWP was present.<sup>1</sup>In regard to the role played by coal dust in the cause of COPD, while dust may lead to the development of industrial bronchitis and minor abnormalities of large-airways function, cigarette smoking is between six and ten times more important.<sup>2</sup>Moreover, industrial bronchitis does not lead to emphysema and is not peculiar to miners, but occurs in all dusty trades. Why, therefore, should miners be singled out for special attention? Nowhere has it been shown that the effects of coal dust and smoking are additive, and studies from the National Coal Board have shown that with increasing age and exposure, the contribution of dust to
Cocarcinogenic Effect of Ultraviolet Light on DMBA Tumor Initiation in Albino Mice
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blockade of XBP1 Splicing by Inhibition of IRE1α Is a Promising Therapeutic Option in Multiple Myeloma
Authors: Naoya Mimura, Mariateresa Fulciniti, Gullu Gorgun, Yu-Tzu Tai, Diana D. Cirstea, Loredana Santo, Yiguo Hu, Claire Fabre, Jiro Minami, Hiroto Ohguchi, Tanyel Kiziltepe, Hiroshi Ikeda, Yutaka Kawano, Martina Blumenthal, Victor Tam, Nathalie L. Kertesz, Mark Hokenson, Qingping Zeng, John B. Patterson, Paul G. Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood (2011)
Pneumobilia associated with small-bowel obstruction
Authors: J. L. Bautista
Journal: JAMA (1988)

We present a patient who was admitted complaining of nausea, vomiting, and abdominal distention. A roentgenogram of the abdomen revealed a dilated stomach and pneumobilia. At surgery, he was found to have proximal small-bowel obstruction. To our knowledge, this is the first case of pneumobilia associated with proximal small-bowel obstruction not associated with a gallstone. (<i>JAMA</i>1988;260:1930-1931)
Consent to treatment.
Authors: Hillas Smith
Journal: BMJ (1981)

clusive: Illis and Merry11 claimed that treatment with steroids had reduced mortality from 700" to 4400 in all recorded cases of simplex encephalitis; nevertheless, six patients in the London Hospital series given dexamethasone showed little effect.3The antiviral agents used in herpes simplex virus encephalitis have been mainly the pyrimidine analogues, idoxuridine,12-14 cytosine arabinoside,'0 15 and adenine arabinoside.16 17All of these compounds have the disadvantage that, despite an undoubted antiviral effect in vitro, their action cannot easily be concentrated at the site of the local brain lesion because of poor solubility of the drug or inadequate penetration of the blood- brain barrier.Few trials have been reported, but a placebo- controlled study in the United States17 suggested that adenine arabinoside may reduce mortality without toxicity.
ALLEGED INSANITY IN THE ARMY ABROAD.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-007 The National colonoscopy audit: a nationwide assessment of the quality and safety of colonoscopy in the UK
Authors: D Gavin, R Valori, J Anderson, M Donnelly, J G Williams, E Swarbrick
Journal: Gut (2012)

<h3>Introduction</h3> Colonoscopy is the gold standard procedure for the diagnosis and non-surgical management of colonic disease. Poor quality colonoscopy is associated with complications and reduced effectiveness in disease prevention. A previous large-scale study of colonoscopy practice in the UK demonstrated disappointing results with poor caecal intubation rates and higher than expected complication rates.<sup>1</sup> Since then there has been significant investment in endoscopic training, a quality assurance framework for endoscopy units has been implemented and the National Bowel Cancer Screening Program has been rolled out nationally. The aim of this study was to assess the quality of contemporary UK colonoscopy. <h3>Methods</h3> A nationwide audit of colonoscopy practice was conducted over a 2-week period from 28 February 2011 until 11 March 2011. The study was performed prospectively, with data entry occurring electronically through a purpose built website (http://www.endoaudit.com). All units performing &gt;100 colonoscopies annually on NHS patients were included. All colonoscopies performed on adults (&gt;16 years of age) were included. Data on key performance indicators and complications was collected and analysed. <h3>Results</h3> Data on 20 085 colonoscopies and 2681 colonoscopists were collected from 301 units. A validation exercise indicated that data were collected on &gt;94% of all procedures performed nationally. The overall, unadjusted caecal intubation rate (CIR) was 92.3%. When adjusted for impassable strictures and poor bowel preparation the CIR was 95.8%. The polyp detection rate (PDR) was 32.1%. The PDR for significant polyps (&gt;1 cm diameter) was 11.7%. 92.3% of resected polyps were retrieved. 90.2% of procedures achieved acceptable levels of patient comfort. A total of eight perforations and 52 significant haemorrhages were reported. Eight patients underwent surgery as a consequence of a complication. <h3>Conclusion</h3> This is the first national audit of colonoscopy that has successfully captured the majority of adult colonoscopy performed during a defined time period. The data confirm that there has been a significant improvement in performance of colonoscopy in the UK since the last study reported 7 years ago (CIR 76.9%) and that performance is above the required national standards. <h3>Competing interests</h3> None declared. <h3>Reference</h3> 1. <b>Bowles CJ</b>, Leicester R, Romaya C, <i>et al.</i> A prospective study of colonoscopy practice in the UK today: are we adequately prepared for national colorectal cancer screening tomorrow? <i>Gut</i> 2004;<b>53</b>:277–83.
Binding of Polychlorinated Biphenyls to the Aryl Hydrocarbon Receptor
Authors: Sherif A. Kafafi, Hussein Y. Afeefy, Ali H. Ali, Hakim K. Said, Abdel G. Kafafi
Journal: Environmental Health Perspectives (1993)

A new thermodynamic model for calculating the dissociation constants of complexes formed between the aryl hydrocarbon receptor (AhR) and polychlorinated biphenyls (PCBs) is reported. The free energies of binding of PCBs to AhR are controlled by their lipophilicities, electron affinities, and entropies. The corresponding physicochemical properties of polychlorinated dibenzo-p-dioxins and dibenzofurans also control their interactions with AhR. We present evidence supporting the hypothesis that the majority of PCBs are likely to interact with AhR in their nonplanar conformations. In addition, we demonstrate that the affinities of PCBs for AhR relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin correlate with corresponding toxic equivalency factors in animals. The reported methodology is likely to be applicable to other polyhalogenated and mixed polyhalogenated bi- and terphenyls and related xenobiotics; thus, it could minimize the number of in vivo studies in laboratory animals and facilitate the identification of potentially hazardous aromatic xenobiotics.
WHOLESALE GEOGRAPHIC SURGERY
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ICU Burnout
Authors: JUDITH ANNE CULPEPPER
Journal: Annals of Internal Medicine (1988)

I cringe at the sight of your blood Because it is the color of my own. We are like strings tuned to the same note, So that I resonate to your cry of pain. Stop hurting me with your hurt, I implore you. I'm fragile like a delicate crystal glass: If you scream I may shatter.
Interaction of the wallstent with the coronary artery during a longterm follow-up: morphological assessment by serial intravascular ultrasound with a motorized pullback system
Authors: A. König, E. Regar, K.-H. Henneke, V. Klauss, F. Werner, J. Rieber, J. Metz, K. Theisen, H. Mudra
Journal: Journal of the American College of Cardiology (1998)
OA21.02 ALK-Rearranged Non-Small Cell Lung Cancer is Associated with a High Rate of Venous Thromboembolism
Authors: Alona Zer, Mor Moskovitz, David Hwang, Anat Hershko-Klement, Ludmila Fridel, Grzegorz Korpanty, Elizabeth Dudnik, Nir Peled, Tzippy Shochat, Natasha Leighl, Geoffrey Liu, Ronald Feld, Ronald Burkes, Mira Wollner, Ming Tsao, Frances Shepherd
Journal: Journal of Thoracic Oncology (2017)