tbuckley/cabot-search huggingface dataset:
Xenografts
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INDICTMENT OF HEALTH OFFICIALS.
Journal: JAMA (1899)

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Clinical Medicine. I: Tuesday Clinics at the Johns Hopkins Hospital.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Local delivery of adenoviral vectors encoding murine interleukin 10 induces colonic interleukin 10 production and is therapeutic for murine colitis
Authors: J O Lindsay
Journal: Gut (2003)

Interleukin 10 knockout (IL-10-/-) mice spontaneously develop a Th1 T cell mediated colitis with many similarities to Crohn's disease. Daily injections of IL-10 are unable to induce remission in mice with established disease. In contrast, we have shown previously that intravenous administration of adenoviral vectors encoding IL-10 (AdvmuIL-10) induces hepatic IL-10 release and leads to long term disease suppression with profound systemic immunoregulatory changes.To determine whether rectal delivery of AdvmuIL-10 induces localised colonic IL-10 expression without systemic immune suppression, and assess its therapeutic efficacy in IL-10-/- mice with established colitis.A single rectal infusion of 5 x 10(8) PFU AdvmuIL-10 to 10 week IL- 10-/- mice resulted in a median level of 27.3 pg/mg IL-10 in colonic homogenates harvested one week later. IL-10-/- mice with established colitis treated with an enema of 5 x 10(8) PFU AdvmuIL-10 entered clinical and histological remission whereas empty cassette adenovirus (Adv0) or phosphate buffered saline (PBS) treated mice developed progressive disease. After four weeks, the histological score of AdvmuIL-10 treated mice (4.4 (1.5)) was significantly lower than that of Adv0 (11.1 (1.1); p<0.001) and PBS (10.9 (1.0); p<0.01) treated controls. In addition, the stool concentration of IL-1beta over the four week experiment was significantly higher in mice treated with saline or Adv0 than in those treated with AdvmuIL-10 (p<0.01).Local AdvmuIL-10 therapy reverses colitis in IL-10-/- mice without the systemic effects seen after intravenous administration. Gene therapy strategies using adenoviral vectors encoding immunoregulatory cytokines may prove to be a potent approach to the treatment of chronic inflammatory diseases such as Crohn's disease.
<i>The Diagnosis of Nervous and Mental Diseases.</i>By Howell T. Pershing, M. Sc., M. D., Professor of Nervous and Mental Diseases in the University of Denver, etc., Member of the American Neurological Associaiton. Illustrated. 12mo. (Published by P. Blakiston's Son &amp; Co., 1012 Walnut Street, Philadelphia, 1901.) Price, in cloth, $1.25 net
Authors: H. B. J.
Journal: American Journal of Psychiatry (1902)
Loma Linda MD/pilots should train at USC
Authors: K. R. Doram
Journal: JAMA (1991)

<h3>In Reply.</h3> —Since physicians, partly because of their economic status, are more likely than the general US population to own and use private aircraft,<sup>1,2</sup>their higher risk of death from aircraft accidents is not surprising (LLU, 38 deaths, standardized mortality ratio [SMR] = 1318; USC, 7 deaths, SMR = 360). As Dr Doram's letter underscores, what we could not account for in our study is why the risk of fatal aircraft accidents was three times higher for LLU physicians than for USC physicians (mortality ratio was 2.98 [95% confidence interval, 1.27 to 6.96]. We tested several hypotheses to elucidate this difference. <h3>The international service hypothesis.</h3> —Since LLU physicians provide service to the worldwide network of Seventh-day Adventist medical facilities, we tested the possibility that the increased risk of aircraft accidents might be attributed to the frequent use of private aircraft in their assignments. We found, however, that 88% of the aircraft
Bear Mountain
Authors: M. Kirk Gooding
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1945)

Prognosis in Hodgkin's Disease Q.-Does comnplete recovery fromn Hodgkin's disease ever occur, and if so, after what interval, dluring which the patient is free from signs and symptoms, can it be assuimed to haoe taken place?If complete recovery is possible, in what percentage of cases does it occutr ?A.-There is no evidence that complete recovery from Hodgkin's disease ever occurs.About 80% of the subjects die within three years of the onset of symptoms, and only about 5% live more than five years.In any large series of cases there will be a few with a duration up to ten years, and survival for twenty-five years has been recorded.It is not possible to make an accurate prediction in the individual patient.Even though the patient has been completely free of symptoms for months or years, the disease may suddenly reappear in an acute and rapidly fatal form.
Further Thoughts on the Future of Medical Practice Outside the Hospital
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disposable plastic breathing bags and tubes. Hazards for inhalation therapy and anesthesia
Authors: J. B. Parmley
Journal: JAMA (1971)

Disposable units consisting of plastic masks, reservoir bags, and breathing tubes have been introduced to obviate hazards of cross-infection in anesthesia and inhalation therapy equipment. These are composed of polyethylene plastic that does not stretch after full inflation. Pressures exceeding 250 cm H<sub>2</sub>O may develop in these units. Such pressures are transmitted to the airway and pose hazards. Rupture of intrapulmonary structures, cardiac tamponade, and other adverse effects may result. Pressures of such magnitude do not develop in all-rubber units. Reservoir bags in disposable units for anesthesia and inhalation therapy should be composed of rubber or other material having the distensibility of rubber.
AN ESTEEMED PHYSICIAN, TEACHER, INVESTIGATOR, AND MEDICAL STATESMAN
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Financial Advice to a Young Man. A Program for Getting Along in the World.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The kidney or the machine?
Authors: J. P. Kemph
Journal: JAMA (1977)

WHEN a person's renal function fails, he has three options: renal homotransplantation, dialysis, or to do nothing. With the last, the uremic syndrome progresses to apathy, drowsiness, anorexia, depression and mild mental confusion, and eventually psychosis. The patient becomes more irritable and less able to control his impulses. He has a greater tendency to deny that he is ill. He covers his feelings of depression, anxiety, fear, and anger, and he tends to blame others for his weakness. The use of kidney transplantation as a treatment for renal failure is rapidly gaining in popularity, yet physicians tend to prefer dialysis. Further, once the decision for dialysis is made, the possibility of transplantation is not often reconsidered. Both are important modalities of treatment, although the psychologic problems are often considerable. Many articles provide information about the improving survival rate of patients receiving transplants; few, however, describe the sociopsychological aspects or the
Recent Advances In The Molecular Biology Of Htlv-1: Trans-Activation Of Viral And Cellular Genes
Authors: M Yoshida
Journal: Annual Review of Immunology (1987)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Acute Exposure to Environmental Tobacco Smoke and Heart Rate Variability
Authors: C. Arden Pope, Delbert J. Eatough, Diane R. Gold, Yanbo Pang, Karen R. Nielsen, Prema Nath, Richard L. Verrier, Richard E. Kanner
Journal: Environmental Health Perspectives (2001)

Environmental tobacco smoke (ETS) has been associated with cardiovascular mortality. Pathophysiologic pathways leading from ETS exposure to cardiopulmonary disease are still being explored. Reduced cardiac autonomic function, as measured by heart rate variability (HRV), has been associated with cardiac vulnerability and may represent an important pathophysiologic mechanism linking ETS and risk of cardiac mortality. In this study we evaluated acute ETS exposure in a commercial airport with changes in HRV in 16 adult nonsmokers. We conducted ambulatory electrocardiographic (ECG) monitoring for 8-hr periods while participants alternated 2 hr in nonsmoking and smoking areas. Nicotine and respirable suspended particle concentrations and participants' blood oxygen saturation were also monitored. We calculated time and frequency domain measures of HRV for periods in and out of the smoking area, and we evaluated associations with ETS using comparative statistics and regression modeling. ETS exposure was negatively associated with all measures of HRV. During exposure periods, we observed an average decrement of approximately 12% in the standard deviation of all normal-to-normal heart beat intervals (an estimate of overall HRV). ETS exposures were not associated with mean heart rate or blood oxygen saturation. Altered cardiac autonomic function, assessed by decrements in HRV, is associated with acute exposure to ETS and may be part of the pathophysiologic mechanisms linking ETS exposure and increased cardiac vulnerability.
Combined heterozygosity of factor V Leiden and the G20210A prothrombin gene mutation in a patient with cerebral cortical vein thrombosis
Authors: Xiao‐Yuan Liu, Theodore G. Gabig, Nils U. Bang
Journal: American Journal of Hematology (2000)

Cerebral venous thrombosis (CVT) is a rare type of stroke with a variety of causes. Several reports have suggested that either factor V Leiden or G20210A prothrombin gene mutation is associated with an increased risk of CVT. The genetic thrombophilias are typically associated with other predisposing factors. We report a unique case of CVT in a patient with both the factor V Leiden and the G20210A prothrombin gene mutations without other identifiable precipitating factors in a 28-year-old white male in good health. MRI and cerebral arterial angiography showed cerebral cortical venous thrombosis. This case suggests that combined heterozygous individuals may be particularly prone to spontaneous thrombosis, like CVT. Am. J. Hematol. 64:226–228, 2000. © 2000 Wiley-Liss, Inc.
Olaratumab Approved for Soft-Tissue Sarcoma
Journal: Cancer Discovery (2016)

Abstract The FDA has granted accelerated approval to the monoclonal antibody olaratumab, combined with doxorubicin, as first-line therapy for patients with inoperable soft-tissue sarcoma. In a randomized phase II trial, the median overall survival was 26.5 months for patients who received this combination, versus 14.7 months for those who received only doxorubicin.
Movies and Conduct
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Revelation
Authors: Bhuvana Chandra
Journal: Annals of Internal Medicine (2015)

Ad Libitum1 December 2015RevelationBhuvana Chandra, MDBhuvana Chandra, MDFrom Porter Ranch, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-1852 Audio Reading - “Revelation” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Revelation," by B. Chandra. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail There was pink medicine. And green. Theysloshed inside bottles of mottled glass so thickthat not even my brothers could shatter it. Andcastor oil! Nemesis of our honeyed lives, ourparents' secret weapon. One dose could fendall run-of-the-mill ills; it didn't matter to themthat we kept our lips clenched, it slid in sidewise.an aluminum pan (its stark sheen ... Author, Article, and Disclosure InformationAffiliations: From Porter Ranch, California.Current Author Address: Bhuvana Chandra, MD; e-mail, [email protected]rr.com. PreviousarticleNextarticle Advertisement Audio Reading - “Revelation” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Revelation," by B. Chandra. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 1 December 2015Volume 163, Issue 11Page: 860KeywordsEpileptic seizuresFallsOilsSleepTicksTyphoid ePublished: 1 December 2015 Issue Published: 1 December 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Bronchial Carcinoma: Incidence and Aetiology.--II
Authors: R. Doll
Journal: BMJ (1953)

Consumption of TobaccoThe possibility that a relationship exists between the smoking of tobacco and the development of bronchial carcinoma has been suggested often-and over a period of many years.At first the suggestion was made either on theoreti-cal grounds or because of the clinical observation that the patients tended to be heavy smokers.In support it was pointed out that national figures for tobacco con- sumption showed increases over the same period in which the recorded lung cancer death rates had increased.In the absence of positive animal experiments, or of detailed knowledge of normal smoking habits, such considerations carried little weight, and it is invidious to try to determine who first suggested that tobacco might be a factor.Direct evidence of a relationship was first secured in 1939 by Muller, in Germany.He obtained the smoking histories of 86 male patients with bronchial carcinoma from hospital notes, by personal interview, or from a questionary sent to the relatives of the patients who had died; he com- pared them with histories given by 86 healthy men of the same ages.The results showed gross differences between the groups in the proportions of non-smokers and of heavy smokers, but the different methods by which the data were collected made it difficult to draw firm conclusions from the comparison.Subsequently other workers have used similar methods to study the problem-that is to say, they have obtained records of the smoking habits of patients with bronchial carcinoma and have compared these with records of other subjects, assumed to be representative of the population TABLE III.-Smoking Habits of Men With and Without Lung Cancer Percentage of Percentage of No. of Men Non-smokers* Heavy Smokers*