tbuckley/cabot-search huggingface dataset:
John C. Dalton, Jr. (1825-1899) experimental physiologist
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term results of the first study of early liver transplantation for alcoholic hepatitis
Authors: Sebastien Dharancy, Christophe Moreno, Jérôme Dumortier, Claire Francoz, Jean-Charles Duclos-Vallée, Marie-Noëlle Hilleret, Lassailly Guillaume, Alexandre Louvet, Francois Durand, Didier Samuel, Georges-Philippe Pageaux, Philippe Mathurin
Journal: Journal of Hepatology (2020)
SAT0469 Osteoarthritis Is The Most Frequent Cause of Rheumathoid Arthritis Misdiagnosis in A Colombian Specialized Center
Authors: P. Santos-Moreno, L. Villarreal, G. Ballesteros, J. Bello, E. Castillo, R. Giraldo, D. Gomez, A. Aza, A. Lopez, A. Cardozo, N. Palacio, D. Buitrago-Garcia, C. Castro
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> There is a lack of expertise in rheumatoid arthritis (RA) diagnosis in primary level of Colombian medical centers, leading to misdiagnosis; many times osteoarthritis (OA) and another rheumatic diseases are misdiagnosed as RA which derives in wrong treatment for patients with clinical and health economics implications. <h3>Objectives</h3> The objective of this study was to describe demographic and clinical characteristics of a cohort of patients derived to a specialized RA center with presumptive RA diagnosis and finally diagnosed as osteoarthritis. <h3>Methods</h3> A descriptive cross sectional study was done. Patients referred to a specialized RA center in a 48 month period with presumptive diagnosis of rheumatoid arthritis were assessed. Each patient was evaluated to confirm or rule-out diagnosis of RA as follows: a rheumatologist fulfilled a complete medical record, including all previous clinical, laboratories and imaging data; it was assessed rheumatoid factor, anti-citrullinated antibodies and other laboratories depending on each case. Also were made x-rays of hands and feet, and in some cases of persistent doubt about the diagnosis was requested comparative MRI of hands or/and feet. Frequencies and percentages were calculated for the demographic and clinical characteristics of the cohort of patients in which the diagnosis of RA was ruled-out. <h3>Results</h3> A total of 5176 patients derived during the last four years to specialized in RA center with presumptive RA diagnosis, after medical, laboratory evaluation and imaging had a wrong RA diagnosis; of them patients 2930 (57%) had finally osteoarthritis diagnosis and of these patients 2594 (88%) were women and 336 (12%) men, with an average age of 59 ± 13 years old. Majority of these patients were followed by general physicians or internists and treated with non-biologic and some few cases with biologic disease modifying anti-rheumatic drugs (DMARDs) in the past years, for an average time of 4.5 years. <h3>Conclusions</h3> In this cohort of patients the most frequent diagnosis of patients misdiagnosed with RA was osteoarthritis, being more than two thirds of them, predominantly women. This shows the need for the implementation of specialized clinics in RA and educational strategies for primary care physicians in order to avoid the impact of this wrong diagnosis. <h3>Disclosure of Interest</h3> None declared
Fluoride Intoxication
Authors: George L. Waldbott
Journal: JAMA (1980)

<h3>To the Editor.—</h3> In the article entitled "Treatment of Primary Osteoporosis With Fluoride and Calcium" (243:446, 1980), the authors recorded rheumatic symptoms suggestive of synovitis and a painful plantar fascial syndrome following treatment with sodium fluoride for osteoporosis in daily doses of 40 to 65 mg. They also observed recurrent vomiting, dyspepsia, arthralgias, alopecia, cerebral demyelination, peripheral neuritis, Parkinson's disease, retinal macular degeneration, and anemia that they did not definitely attribute to fluoride treatment. This nonskeletal phase of fluoride intoxication is not confined to therapeutic administration of fluoride and to industrial fluorosis. It was first described in cryolite workers in the classic book by Roholm.<sup>1</sup>Fluoride intoxication is not uncommon before the development of bone changes among residents near aluminum, steel, and other metal smelteries and fertilizer factories where fluoride pollutes the air and contaminates edible vegetation.<sup>2</sup> From the vicinity of an Ohio enamel smeltery, where fluoride is
EMETIN AND AMEBIASIS
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis
Authors: J Li
Journal: Hepatology (1994)

One of the contributory factors to the development of cirrhosis is a decrease in collagenase activity, which may be related to levels of inhibitors such as serum tissue inhibitor of metalloproteinase. We therefore measured serum tissue inhibitor of metalloproteinase and serum procollagen III peptides (another proposed marker of fibrosis) in 16 healthy controls and 44 alcoholic patients with biopsy-proved liver disease, namely steatosis without fibrosis (n=13), perivenular fibrosis (n=10), septal fibrosis or cirrhosis or both (n=15) and alcoholic hepatitis (n=6). In alcoholic patients, serum tissue inhibitor of metalloproteinase values strongly correlated with fibrosis (rs=0.70, p<0.001). Compared with values in controls (177 ± 12 ng/ml), serum tissue inhibitor of metalloproteinase was significantly elevated in perivenular fibrosis (330 ± 22 ng/ml, p<0.05), in septal fibrosis, cirrhosis or both (406 ± 29 ng/ml, p<0.001) and in alcoholic hepatitis (526 ± 143 ng/ml, p<0.001) but not in steatosis (204 ± 17 ng/ml). In contrast, procollagen III peptides were significantly increased only in the septal fibrosis-cirrhosis group but not in the perivenular fibrosis group. With the threshold defined as the upper value of the steatosis group (resulting in a specificity of 100%), we found that serum tissue inhibitor of metalloproteinase was elevated in 50% of patients with perivenular fibrosis, in 87% of subjects with extensive fibrosis (septal fibrosis, cirrhosis or both) and in 67% of individuals with alcoholic hepatitis. The overall sensitivity of serum tissue inhibitor of metalloproteinase for detecting either perivenular fibrosis or more extensive fibrosis was 71%. Receiver operating characteristic curve analysis revealed that serum tissue inhibitor of metalloproteinase was significantly better than procollagen III peptides in discriminating alcoholics with fibrosis from those with steatosis (area under the receiver operating characteristic curves, 0.958 ± 0.028 vs. 0.803 ± 0.066, p<0.05). In conclusion, serum tissue inhibitor of metalloproteinase is increased in early fibrotic states in alcoholic liver disease and is a useful marker of precirrhotic and cirrhotic states. (HEPATOLOGY 1994;19:1418–1423.)
An automated medical record system
Authors: J. H. Grossman
Journal: JAMA (1973)

An automated medical record system for ambulatory care has been developed for a prepaid group practice. It has been operational for two years, maintaining the medical records for 20,000 people who have made a total of 80,000 visits. The principal data source is a structured encounter form that is filled out by the care provider at the time of each visit. From these data, a progress note and an updated summary of the patient's medical status are generated by the computer. The same system also produces the aggregate statistics necessary for administration and evaluation. The unique characteristic of this medical information system is its ability to meet, at a reasonable cost, the data needs of both patient care and administration. The potentials of the system for facilitating patient management, evaluation, and planning are also seen as important attributes of this approach.
We physicians are fiduciary failures
Authors: I. V. Markle GB
Journal: JAMA (1978)

IT IS difficult for most members of the medical profession to think of themselves in the role of a fiduciary, especially since many of us not versed in financial jargon do not even know what a fiduciary is. In essence, a fiduciary is a person (or an institution) who holds something of value for another in trust. When one looks at the costs of medical care today, it should become apparent that we are responsible for more than just the physical well-being of the patient; we are in a position to bankrupt him or the society that pays for his care. Every time we order a test or a roentgenogram, send a patient for a consultation, prescribe a medicine or a therapeutic procedure, or admit a patient to the hospital, we are investing his money on his behalf, supposedly for his own health. It is the same as though a
Participants Index
Authors: Abramson Dh, Acers Te, Adams Gww, Aiello Lm, Akashi Rh, Aksamit Aj, Albert Dm, Alcorn Dm, Allansmith Mr66, Allara 65, Allen Aw, Allen Rc, Alpar Jj, Anderson Dr, Anderson Me, Anderson Rl, Arps 154 Arrindell, Arrowsmith Pn, Asbell Pa, Augustine Rj, Azar Dt, Bosniak Sl, Bowman Rw, Bradford Jd, Bradford Rh, Brady Lw, Brancato 114 Brandin, Branemark Pi, Braunstein Ra, Bremer Dl, Brennan Mc, Bresnick Gh, Bridges Wz, Brightbill Fs, Brin Mf, Brindley Go, Brinkley Jr, Brinton Gs, Brockhurst Rj, Brody 85 Bronaj, Bronson Nr, Brownstein 86, Brubaker Rf, Brucker Aj, Brucker Aw, Bruner We, Bryant Wm, Bryson Jr, Buckley Eg 241 Bullock, Burd Em, Burde Rm, Burk Ll, Burke Jm, Burton Tc, Buxton Df, Buxton In, Buzard 245, Buzard Ka, C Cahill, Caldwell Dr, Call Nb, Callahan Ma, Cambie Ej, Cantrill Hl, Caplan Rj, Caroline Pj, Carr Re, Carroll Rp, Casey Ta, Cashwell Lf, Catalano Ra, Chadan 153 Chambers, Chan Cc, Chandler Jw, Chandra Sr, Char Dh, Charap Ad, Charles St, Chawla Dk, Chen Jc, Chen Ks, Chen Wp, Chenoweth Rg, Cinotti Dj, Clarkson Jg, Condon Gp, Conklin Aj, Conklin Rh, Connett 62 Connors, Conrad Hg, Coppenolle Fv, Coscas Gj, Cosman Mp, Cotter Jb, Cowan Cl, Cowden Jw, Cox Cw, Cox Ms, Crandall As, Crawford Jb, E Jr, Croxatto Jo, Culbertson Ww, Cunningham Rd, Cupples Dm, Curtin Dy, Cykiert Rc, Cyrliu 80, D Alessandro, D Amico, Dabezies Oh65, Dallow Rl, Damiano Re, Daniels Sa, Danz Wa, David Rr, Davidian Jl, Davis Jl, Deichman Cb, Del Ma, Delaney Km, Della Rocca Rc, Delori Fc, Demorest Bh, Denham Db, Deutsch Ta, Diaz Rf, Dickens Cj, Diegel Jt, Dietze Tr, Dilly Ln, Dingeldein Sa, Dinning Wj, J Nm, Jackson We, Jaeger Ea, Jaffe Gf, Jaffe Gj, Jaffe Ns, Jakobiec Fa, Jalkh Ae, Jampol Lm, Javitt Jc, Jenkins Pf, Jensen Rp, Jerdan Ja, Jester Jv, Jost Bf, K Kaine, J 93 Kaiser-Kupfer, Kalina Re, Kammer Jf, Kandel Gl, Kao Sf, Karickhoff Jr, Karlin Db, Karp Ej, Karr Dj, Kass Ma, Katz Ji, Katz Lj, Katzen Lb, Kay Mc, Kearns Tp, Keates Rh, Keeney Ah, Kelley Cg, Kelley Ep, Kelley Jj, Kelly Ne, Khorram Kd, Kidd Mn, Kimbrough Rl, Kincaid Mc, Kincaid Wl, King Dg, King Lm, King Ra, Kinyoun Jl, Kirkness Cm, Kivlin Jd, Klein Be, Klein Hz, Klein Jw, Klein Ml, Kleiner Rc, Kline Lb, Klyce Sd, Knobloch Wh, Knox Dl, Koch Dd, Kohler Sj, Kohn Ra, Kolberg 64 Kolker Ae, Kolondy Nh, Kopietz La, Kornmehl Ew, Korth 131 Kosoko, Kowalski Rp, Kracher Gp, Krachmer Jh, Kraff Mc, Kramer Sg, Kranias 90 Kratz Rp, Kreiger Ae, Kritzinger Ee, Krom Raf, Kronish 253, Kropp Tm, Krumeich 126 Krupin, Krush 88 Kupfer, Kushner Bj
Journal: Ophthalmology (1987)
Insurers discriminate unfairly on basis of genetic information
Journal: BMJ (1998)

Antenatal screening for syphilis should not be abandoned Antenatal screening for syphilis in the United Kingdom is routine but lacks any formal or evidence based policy.On p 1617 Hurtig et al report on the first national surveys of syphilis in pregnancy and congenital syphilis.Over three years 121 of the 139 pregnant women treated for syphilis by genitourinary medicine specialists were detected through antenatal screening.Women from ethnic minority groups, who were born abroad, or who were living in London were overrepresented, but cases also occurred in white women born in the United Kingdom and living outside London.Seventeen children were found with presumptive or possible congenital syphilis; mothers not receiving antenatal care or late booking was a risk factor.The authors conclude that abandoning or targeting screening is inadvisable.
New insights into thyroid physiology
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Temperance Lunch.
Authors: T. D. Crothers
Journal: JAMA (1907)

Hartford, Conn., May 8, 1907. <h3>To the Editor:</h3> —I have received a number of inquiries relating to the temperance lunch proposed at Atlantic City, June 6. It should be distinctly understood that this occasion is not to promote any particular theory, or society, or any special effort to enlist or pledge any one to the so-called temperance cause. The purpose is simply to gather, and informally talk over the many questions which are arising about this problem. It seems eminently fitting that the American Medical Association, the largest medical society in the world, should recognize this subject in this simple way, and indicate that we are not indifferent to the medical and hygienic interests which center about it. The Society for the Study of Alcohol has simply volunteered to manage and conduct this event in response to the request of a number of persons who feel that the members of
Phase I pharmacokinetic (PK) study of daily imatinib in combination with docetaxel for patients with advanced solid tumors
Authors: G. S. Chatta, M. Fakih, S. Ramalingam, C. P. Belani, R. K. Ramanathan, W. Zamboni, D. Friedland, D. Lis, S. Tutchko, M. Egorin
Journal: Journal of Clinical Oncology (2004)

2047 Background: Imatinib (Gleevec) is an oral tyrosine kinase inhibitor with established clinical activity in chronic myeloid leukemia & gastrointestinal stromal tumors. Imatinib also targets Kit and the platelet derived growth factor receptor (PDGFR). PDGFR inhibition may result in activity against malignancies of the breast, head & neck, prostate, and lung. Docetaxel, a cytotoxic agent, has known activity in a broad range of solid tumors. Hence, the combination of imatinib with docetaxel may be advantageous. Imatinib and docetaxel are both dependent on cytochrome P450 (CYP3A4) for clearance, hence there is a possibility of pharmacokinetic (PK) interactions. Methods: We conducted a phase I study to establish the recommended phase II dose, and evaluate PK interactions for the above combination. The treatment consisted of daily oral imatinib in combination with docetaxel administered intravenously every 3 weeks. A total of 18 patients with refractory solid tumors with normal organ function were enrolled. Cohort 1: imatinib 400 mg + docetaxel 50 mg/m2 (3 pts); cohort 2: imatinib 600 mg + docetaxel 50 mg/m2 (6 pts); cohort 3: imatinib 400 mg + docetaxel 60 mg/m2 (3 pts); cohort 4: imatinib 400 mg + docetaxel 75 mg/m2 (6pts) . Results: The primary toxicity was a grade 3 skin rash (2 of 3 in cohort 2), necessitating treatment with steroids and discontinuation of the imatinib. One pt in cohort 2 experienced an intratumoral retroperitoneal bleed. The dosages in cohort 3 were well tolerated. However 2 of 6 pts in cohort 4, experienced DLT (febrile neutropenia). PK analysis of imatinib was performed on d1 & d7; and PK analysis of docetaxel on d7 by LC/MS assays developed by us. In all the 18 pts analyzed, there was no interaction between the imatinib and docetaxel. Six of eight patients with advanced prostate cancer, who enrolled on the study, experienced a ≥50% reduction in PSA. Conclusions: Thus, the recommended phase II dose of the above combination is: imatinib 400 mg po qd + docetaxel 60 mg/m2 q 3 weeks. At these dosages, the regimen is well tolerated. 12 additional patients are being currently accrued at this dose. (Supported by Novartis & NIH #5M01 RR 00056). Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aventis; Novartis Aventis; Sanofi Aventis; Novartis
Life Sciences, Oxford
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coronary artery bypass grafting for the reduction of mortality: an analysis of the trials.
Authors: J R Hampton
Journal: BMJ (1984)

from hospital specialists to general practitioners, and the presence of a general practitioner research group might stimulate a healthy state of affairs in which the hospital disciplines might learn something from general practice.Some form of ethical control is needed for research in general practice.Ethical considerations should be included in the research element of vocational training courses, and advice is available through the Royal College of General Practitioners, but again a local body would be helpful.Local medical committees might see this as within their scope, or again postgraduate centres might be a focus for an ethical committee.Membership of such committees might include representatives of patient groups such as community health councils as well as general practitioners and hospital doctors.At present the only arbiters of ethical and scientific quality seem to be the journals to which completed papers are sub- mitted for publication.Unfortunately, by then the damage may have already been done, both to the future enthusiasm of the researchers, who (with the best intentions) may have produced an ill conceived and poorly executed piece of research, and to the patients on whom it was carried out.Many improvements are, therefore, possible both in motivating general practitioners to do good research and in pro- viding them with facilities.Nevertheless, we should remember that good general practice is primarily concerned with providing medical services, both technological and humanitarian, to the patient, and that, though research can and should improve the ways in which this is done, it must not become the tail that wags the dog.