tbuckley/cabot-search huggingface dataset:
Acute Myocardial Infarction and Allergy, Causal or Casual Relationship?
Authors: José I. Morgado Garcia-Polavieja, Margarita Castillo Paredes, Enrique López Herrero, Francisco Javier Fernández López, Ana Blanca Paloma Martínez Pérez, José Francisco Díaz Fernández
Journal: Clinical Cardiology and Cardiovascular Interventions (2021)

A 53-year-old man with a known allergy to metamizole presented for acute gonalgia, receiving metamizole by mistake. He suffers a severe allergy reaction accompanied by chest pain and signs of acute lower myocardial infarction, which subsides with treatment of anaphylactic shock and fibrinolysis, without observing intracoronary thrombus or signs of complication of atherosclerotic plaque. LEARNING OBJECTIVE An exceptional clinical case is presented illustrating an acute myocardial infarction related to a severe allergic reaction. In addition, a review of the optimal management of this entity is carried out. We intend to make this entity known, which should be suspected in the appropriate clinical setting
Reader bias
Authors: R. Owen
Journal: JAMA (1982)

<i>BIAS</i>is defined as any process at any stage of inference that tends to produce results or conclusions that differ systematically from the truth.<sup>1</sup>Inference is the mental process whereby one uses specifics (eg, the results of a study) to support a generalization. By tradition, one confines the formal discussion of biases to those that originate in the inference performed by the investigator. I will call this form of faulty inference<i>investigator, bias</i>. Thirty-five investigator biases have been defined and catalogued.<sup>2</sup>But bias, as defined previously, may also occur during the inference conducted by the reader; I'll call this form of bias<i>reader bias</i>. Thus, the defining feature of these two classes of bias is their source—investigator bias arising from the investigator (or his investigation) and reader bias from the reader. A second important difference lies in how these two types of bias are avoided or remedied. Usually,
A Global Champion for Health—WHO’s Next?
Journal: PLoS Medicine (2016)

The World Health Organization (WHO) should not only be a force for good but a source of pride.Since the organization's inception in 1948, landmark achievements in health have included the eradication of smallpox and the well-advanced, but still ongoing, project to consign poliomyelitis to history.The body's normative functions are needed to prepare for and deploy appropriate responses to incipient health threats, notably those wrought by infectious diseases outbreaks, and underpin continuing tasks, for instance that of bringing the HIV epidemic under control.Transformational campaigns led by WHO have included the Framework Convention on Tobacco Control, enacted in 2005, a treaty that prioritized the enormous health benefits of smoking cessation for the world's population.In drafting this Editorial, we sought opinions from members of PLOS Medicine's editorial board and others, and Margaret E. Kruk, of the Harvard T.H. Chan School of Public Health, noted that "WHO is. ..seen by most as embodying our shared global health aspirations.Because of this its pronouncements carry great weight."Given WHO's global footprint and responsibilities in addressing the many serious threats to health in diverse settings, the organization does not lack critics.This sprawling empire of more than 7,000 employees, headquartered in Geneva, Switzerland, has a presence in 150 of the organization's 194 constituent countries, along with six regional offices, and has a bureaucracy and running costs to match.As global health has grown in the public consciousness in recent decades, WHO has come to work alongside, and invite comparisons with, some tightly focused and handsomely funded newer organizations that lack the explicit public accountability of a United Nations agency.Often, communicators about health are prolific and strident in their criticism of existing structures and organizations, especially WHO.Owing to its complex constitution and broad remit, WHO can be perceived to be slow-moving, inefficient, and unresponsive to changing situations-to lack effective leadership, in other words.In 2014-2015, the disastrous West African outbreak of Ebola brought about a watershed moment for WHO.Despite current Director-General Margaret Chan's earlier experience in addressing the 2003 outbreak of Severe Acute Respiratory Syndrome in Hong Kong, the agency's response to the threat of Ebola was seen to be sluggish and indecisive.Enormous disruption and a substantial toll of deaths ensued.While the crisis was exacerbated by weak country health systems, combined with a poor understanding about the pathogenesis of and necessary control measures for Ebola infection, WHO was perceived to be responsible for the erratic overall response to the outbreak.This episode has recently been discussed by Lawrence O.
Alternative Hypotheses for the Role of Promotion in Chemical Carcinogenesis
Authors: Van Rensselaer Potter
Journal: Environmental Health Perspectives (1983)

A new protocol for carcinogenesis in rat liver is described in order that confirmatory experiments might be undertaken concurrently. The basic protocol, designated IPI (initiator + promoter + initiator), is presented in several alternative forms, including the possible use of X-irradiation as the initiator. The rationale is discussed in terms of the two-hit somatic mutation theory of Armitage and Doll, with an initial hit produced by the first dose of initiator and expansion of single cells to sizable clones by promotion thereby increasing the probability of a second hit by the second dose of initiator. The question of relevant mutations was taken up and it was proposed that genes for chalones (C) and for chalone receptors (R) are logical targets for consideration in a two-mutation sequence. Alternative hypotheses pertaining to promoter action were described in terms of possible mechanisms by which nonelectrophilic promoters might simulate a second mutation by increasing or decreasing the levels of a nonchromosomal replicating particle in target cells.
Burrowing through blocked arteries with a balloon 'relocates' plaques
Authors: M. Annexton
Journal: JAMA (1978)

In the wake of the current controversy concerning the value of coronary bypass surgery, alternative methods for dealing with some forms of heart disease command special attention. So it is with the recently publicized use of a balloon catheter for "relocation" of plaque in the arteries to increase their patency. On June 15, 1978, the<i>New York Times, Time</i>magazine, CBS's Walter Cronkite, and the<i>International Herald Tribune</i>all reported on a "balloon which clears up heart arteries." A press conference on the subject had been held by Simon Stertzer, MD, head of the Hemodynamics Laboratory at New York's Lenox Hill Hospital. The four news articles tell the same story: A patient at Lenox Hill Hospital agreed to forego coronary artery bypass surgery to repair his clogged arteries and opted for percutaneous transluminal coronary angioplasty. In this procedure a small deflated balloon catheter is threaded through the narrowed artery and
Extensive resections for cancer of the large bowel.
Journal: BMJ (1973)

today's shrinking world the World Health Organization has prepared a special issue of the Weekly Epidemiological Record9 giving information for international travellers.It covers (a) the list of countries and areas where the risk of contracting malaria is present, even though it may be remote; (b) advice on how to protect travellers from that risk; and (c) guidance on what to do if fever develops on returning home.The document is divided into two parts.One part presents data on the risk of malaria in some 220 countries and territories all over the world.The second part gives an outline of preventive measures, including chemo- prophylaxis.A succinct table of appropriate drugs and their dosages is appended together with a map showing the epidemiological assessment of the status of malaria in 1972.This document is a useful source of the information that travel agencies, tourist information centres, and other organizations dealing with international travel ought to give their clients.It will also help doctors faced with inquiries afbout proposed or previous visits abroad.
PVC: Health Implications and Production Trends
Authors: Myra Karstadt
Journal: Environmental Health Perspectives (1976)

Poly(vinyl chloride) (PVC) is a complex plastic system. Individual components of the PVC system, including residual vinyl chloride monomer (RVCM) and certain additives, may pose risks of harm to human health. There have been significant reductions in the RVCM content of PVC resin since 1974, reducing the cancer risk of workers in PVC fabrication plants and consumers of PVC products. A "no-effect" level for vinyl chloride monomer (VCM)-induced carcinogenesis has not been found to date; therefore, the significance of human exposure to low levels of RVCM remains to be determined. Exposure to PVC dust may cause pulmonary dysfunctions. Pulmonary and other possible health effects of PVC dust require further study. The PVC plastics system should be characterized as to interactions among its various components and as to interactions of the components and the PVC system as a whole with biological systems.
Kininogen Deficiency Protects From Ischemic Neurodegeneration in Mice by Reducing Thrombosis, Blood-Brain-Barrier Damage and Inflammation
Authors: Friederike Langhauser, Eva Gob, Peter Kraft, Christian Geis, Joachim Schmitt, Marc Brede, Kirsten Göbel, Xavier Helluy, Mirko Pham, Martin Bendszus, Peter Jakob, Guido Stoll, Sven G Meuth, Bernhard Nieswandt, Keith R. McCrae, Christoph Kleinschnitz
Journal: Blood (2012)
Remodeling the house of academe
Authors: R. G. Petersdorf
Journal: JAMA (1989)

In this issue ofThe Journal, Schroeder and colleagues<sup>1</sup>engage in a far-reaching review of American academic medicine. They shower the academic establishment with kudos for its performance in biomedical research, in the development and application of technology, and in progress against specific diseases, and also give us good marks for efforts in screening for preventable disease, in health services research, and in innovations in health care provision. On the other hand, the authors take us to task for our performance in matters of health status, health care costs, quality, manpower mix and distribution, and long-term care and disability and as a training ground for other countries. They argue that because the academic medical center has done well and has received its share of the public purse, it now behooves it to expand its horizons to encompass the problems of the public health; cost control; access for the poor,
The Samuel D. Gross Prize, Philadelphia Academy of Surgery.
Journal: JAMA (1892)

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IS IT HERESY FOR AN EDDYITE TO HAVE SUPERFLUOUS HAIR REMOVED?
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
United Kingdom Beryllium Registry: Mortality and Autopsy Study
Authors: W. Jones Williams
Journal: Environmental Health Perspectives (1996)

This report is based on 30 deaths from chronic beryllium disease (CBD) in the United Kingdom with details of 19 autopsies.The majority were fluorescent lamp workers and machinists who died from respiratory failure.There were no cases of lung cancer.The survival times ranged from less than 1 to 29 years and was longest in machinists.All of the workers showed interstitial pulmonary fibrosis with varying degrees of cystic change.The majority showed hyalinized, and a few active sarcoid-type, granulomas.Extrathoracic granulomas, as in a U.K. sarcoid autopsy series, were rare.A notable difference was the absence of myocardial involvement in CBD compared to an incidence of 20% in the sarcoid autopsies.The detection of beryllium in the criteria for diagnosis is emphasized and the cases classified as definite include 12 of 19 positive analysis, 6 of 19, negative or unavailable analysis.The remaining case was classified as dubious because, despite a positive analysis, granulomas were absent.The main differential diagnosis is sarcoidosis.
Methadone treatment of heroin addicts. Early results provide more questions than answers
Authors: W. H. Dobbs
Journal: JAMA (1971)

Of a random sample of 100 clinic patients receiving methadone maintenance treatment, a majority were still using heroin. The most puzzling finding was that patients who had been in treatment the longest (four to six months) showed evidence of a higher rate of heroin usage than recently admitted patients. A longer-term follow-up study of the same sample group is clearly of some importance, and side-effects of treatment warrant more careful study. There is reasonably strong clinical evidence that methadone is abused.
ALIMENTARY GASES
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug treatment of acute asthma
Authors: A. F. Wilson
Journal: JAMA (1977)

IN RECENT years, a number of effective regimens for the treatment of acute asthma in both children<sup>1</sup>and adults<sup>2</sup>have been devised. If there is one system that is clearly superior, such is not evident either from the literature or from my experience. Hence, in addition to a basic regimen, alternate or additional forms of therapy are outlined. Probably, the amount of drugs used early in the course of acute asthma and for a period extending beyond the acute stage is more important than choosing between several drugs. Also, since the severity of asthma may suddenly improve or worsen, it is necessary to frequently monitor the patient's condition and to assess the effects of treatment. It has been shown that a greater likelihood of prolonged treatment, indicating a need for hospitalization, is found in patients who suffer from severe obstruction and respond minimally to initial therapy.<sup>3</sup> <h3>Initial</h3>
Perspectives
Journal: BMJ (2003)

saved per 100 patients treated.Benefits from prehospital thrombolysis have also been shown to include a reduction in overall morbidity. 6 In all the groups, ambulance response time, defined as the time from calling for professional help to the arrival of an emergency ambulance, shows a marked difference between patients calling their general practitioner and those who dial 999.Although the contribution of general practitioners in this setting should not be underestimated in clear cut cases, the adoption of the "dual response" suggested by the British Heart Foundation might minimise this delay. 13 Any system of prehospital thrombolysis requires a rapid response to calls about undifferentiated chest pain received from within the community.Over the 12 months of our study the accident and emergency department received 229 calls and effected thrombolysis in 28 patients.Although this ratio is broadly similar for patients receiving thrombolysis in hospital, it underlines the commitment and resources necessary to promote early treatment.We thank R Chan, senior lecturer in cardiovascular epidemiology, for his help with the statistical analysis, Robert Colburn of the Scottish Ambulance Service for his help in establishing the project, and Steve Beedie, ambulance paramedic, for his help in collecting prehospital data.Contributors: DKP designed the study and wrote the paper.KB and EMC collected the data and compiled the database.CGG was involved in the planning, implementation, and audit of the service.IG was responsible for paramedics' training and service development.GM and THP participated in validation of the data.SDP helped plan the service and revised the first draft of the paper.MCJ had the original idea for the provision and design of the service, participated in implementation and audit
Hemodynamic Studies after Mitral Commissurotomy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I study of CC-90011 in patients with advanced solid tumors and relapsed/refractory non-Hodgkin lymphoma (R/R NHL)
Authors: A. Hollebecque, J. de Bono, R. Plummer, N. Isambert, P. Martin-Romano, E. Baudin, S. Mora, A. Harding, A. Nguyen, E. Filvaroff, M. Lamba, K. Liu, J. De Alvaro, J. DiMartino, M. Zuraek, Z. Nikolova
Journal: Annals of Oncology (2018)
BOVINE TUBERCULOSIS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Behavior of the Newborn Infant.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Osteopathy Bill.
Authors: F. K. Granger
Journal: JAMA (1897)

(COPY) Chicago, April 26, 1897. <h3>Dear Senator Granger:</h3> —I have looked over the Osteopathy Bill, as introduced by you, and do not know what arguments were brought to bear upon you to father it, but the Bill is one which will be very unjust to the medical profession in this State, if allowed to pass; besides, it would make the State the dumping ground for quacks. Personally, I would be very pleased to hear that you will quietly pocket the bill, or do something to stop its passage. I am faithfully yours, Illinois Senate, Springfield, Ill.