tbuckley/cabot-search huggingface dataset:
Neuroscience in Psychiatry Training: How Much Do Residents Need To Know?
Authors: Joshua Roffman
Journal: American Journal of Psychiatry (2006)

Objective: With the explosion of research in psychiatric neuroscience, the extent and means by which neuroscientific progress will translate into clinical care remains largely uncertain. The authors sought to determine how this dilemma is currently being played out in residency training programs, in which training directors must decide how best to integrate neuroscience teaching in a rapidly changing clinical landscape. Method: The authors surveyed U.S. and Canadian psychiatry residency training directors to characterize current and future trends in neuroscience education and to examine training directors' views on the relevance of neuroscience to clinical practice. Results: The amount of neuroscience in residency curricula has increased significantly over the past 5 years, and further increases are expected in each specific neuroscience content area examined. While most training directors agreed that training in neuroscience was important for all residents, even those becoming primarily psychotherapists, relevance to future (but not current) practice was consistently cited as a motivating factor. Conclusions: While psychiatric residency programs continue to increase the neuroscience content of their curricula, it remains unclear how this added training will influence clinical work. Reframing current practices, including psychotherapy, into a neuroscientific context may ultimately prove more useful to trainees.
An Ongoing Phase 1/2a Study of ABT-263; Pharmacokinetics (PK), Safety and Anti-Tumor Activity in Patients (pts) with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL).
Authors: Andrew W. Roberts, John F Seymour, Jennifer R Brown, William G Wierda, Thomas J. Kipps, Dennis Carney, Hao Xiong, Yue Cui, Todd Busman, Sari Enschede, Andrew Krivoshik, Rod Humerickhouse
Journal: Blood (2009)
Physicians looking at themselves
Authors: J. S. Todd
Journal: JAMA (1989)

For more than a decade, professional liability, often inappropriately labeled "malpractice," has bedeviled all physicians regardless of their specialty or indeed their recognized competence. Critics repeatedly charge the profession with failing to deal with the problem, while at the same time state that joint underwriting associations and "surplus lines" companies make it possible for physicians to obtain insurance, not infrequently ignoring evidence of substandard performance or extensive claims history. More recently, an attack has begun on the insurance industry as the root cause of professional liability expense. With 42 physician-owned and -controlled professional liability companies, it is blatantly unlikely that these companies would not adhere to lean insurance principles often having to follow the mandates of the very insurance commissioners now critical of their performance. Elsewhere in this issue, Schwartz and Mendelson<sup>1,2</sup>present important previously uncollated demographic data suggesting that physician-owned insurance companies, once, but no longer, derogatorially known
Comparing the prevalence of smoking in pregnant and nonpregnant women, 1985 to 1986
Authors: D. F. Williamson
Journal: JAMA (1989)

The 1990 health objectives for the nation state that pregnant women should be only half as likely to smoke as nonpregnant women. To assess progress toward meeting this objective, we used cross-sectional data from the 26 states in the Behavioral Risk Factor Surveillance System in 1985 and 1986. We compared the prevalence of self-reported smoking among pregnant (N = 836) and non-pregnant (N = 18 025) women aged 18 to 45 years. Overall, pregnant women were 70% as likely to be current smokers as nonpregnant women (prevalence ratio, 0.7; 95% confidence interval, 0.6 to 0.8), while blacks showed the largest pregnancy-associated reduction in the prevalence of smoking (prevalence ratio, 0.5; 95% confidence interval, 0.3 to 0.9). Most of the difference in smoking prevalence occurred not because pregnant women were less likely to have ever smoked, but because pregnant women were more likely to have quit smoking than nonpregnant women. However, unmarried pregnant white women were 40%<i>more likely</i>to smoke than their nonpregnant counterparts (prevalence ratio, 1.4; 95% confidence interval, 1.1 to 1.7). We conclude from this analysis that the 1990 health objective for smoking among pregnant women is unlikely to be achieved. Clinicians providing care to pregnant women need to pay increased attention to smoking cessation. (<i>JAMA</i>1989;261:70-74)
Hepatitis A Outbreak Associated With Green Onions at a Restaurant—Monaca, Pennsylvania, 2003
Journal: JAMA (2003)

The Pennsylvania Department of Health and CDC are investigating an outbreak of hepatitis A outbreak among patrons of a restaurant (Restaurant A) in Monaca, Pennsylvania. As of November 20, approximately 555 persons with hepatitis A have been identified, including at least 13 Restaurant A food service workers and 75 residents of six other states who dined at Restaurant A. Three persons have died. Preliminary sequence analysis of a 340 nucleotide region of viral RNA obtained from three patrons who had hepatitis A indicated that all three virus sequences were identical. Preliminary analysis of a case-control study implicated green onions as the source of the outbreak.
The Rain
Authors: Stephen Snyder
Journal: JAMA (1988)

"Please go away. Some other time." I am a liaison psychiatrist. I'm accustomed to being turned away by patients. This one is an elderly woman who had a large pelvic sarcoma removed several weeks ago and lost a leg in the process. Things have gone badly for her since then. A wound that won't heal. Fevers. Intractable diarrhea. Your classic surgical patient gone sour. She won't eat. She won't look where the missing leg was. I've been by to see her several times and each time she has refused to see me. "Please. Some other time." She smiles politely. I stand in the doorway. I never know quite why I persist when I do. Maybe it's because I like her. I like her smile, even though it's there to keep me away. It's diplomatic but not phony. She strikes me as warm and wise and considerate. "The nurses are worried
IS UNIVERSAL VEGETARIANISM FEASIBLE?
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Wood's light fluorescence and Pseudomonas burn wound infection
Authors: C. G. Ward
Journal: JAMA (1967)

Invasive infection, usually arising from the burn wound itself, remains the primary danger to the seriously burned man (Table). The offending organism is most often<i>Pseudomonas aeruginosa</i>, although the frequency of and mortality from such sepsis has recently been reduced by effective surface antibacterial agents.<sup>1,2</sup> The onset of<i>Pseudomonas</i>burn sepsis is often insidious, perhaps even more so when the patient is treated with 0.5% aqueous silver nitrate. The organism is notoriously resistant to tolerable anti-bacterial agents, whether administered locally or systemically. Delayed diagnosis and the low therapeutic index of presently available antibiotics are very likely responsible for the high mortality associated with<i>Pseudomonas</i>burn wound sepsis. However, dilute solutions of silver nitrate, when optimally applied, uniformly control the bacteria at the site of invasion, the burn wound itself. Furthermore, every strain isolated from our patients has remained sensitive in vitro to 0.5% aqueous silver nitrate. The delay in
Radiographic diagnosis of aortic-ball variance
Authors: J. C. Hylen
Journal: JAMA (1969)

Assessing changes in the silicone-rubber ball of the Model 1000 series Starr-Edwards aortic-valve prosthesis is an increasingly frequent diagnostic problem. Bariumimpregnated, silicone-rubber balls have been available since 1962. Presently, these constitute slightly less than 10% of all silicon-rubber balls distributed. Radiographic evidence of aortic-ball variance was obtained for a patient having normal sounds of the prosthetic aortic valve as determined by auscultation, phonocardiography, and sound spectrography. All silicone-rubber balls now produced by the manufacturer are barium-impregnated; henceforth, radiographic techniques will be more uniformly applicable to the early diagnosis of aortic-ball variance. Since most patients with aortic-ball variance are asymptomatic, routine screening for the early detection of ball variance is suggested for all patients with barium-impregnated, silicone-rubber balls. Serial high-resolution films and cineradiography should be used.
Two Welsh Surveys of Blood Lead and Blood Pressure
Authors: Peter C. Elwood, George Davey-Smith, Peter D. Oldham, Colin Toothill
Journal: Environmental Health Perspectives (1988)

The relationship between blood pressure and blood lead was examined in two population samples. One of these consisted of 1137 men aged 49 to 65 years, the other of 865 men and 856 women aged 18 to 64 years. Neither population had any known important exposure to lead, and the 95% ranges of blood lead levels were 6 to 26 micrograms/100 mL and 6 to 23 micrograms/mL in the men and 5 to 18 micrograms/100 mL in the women. No significant relationship between blood pressure and blood lead was detected in either of the population samples, and the regression coefficients suggest that if there were a real effect, then the mean difference in blood pressure per 10 micrograms difference in blood lead is likely to be 0.7 mm Hg in both systolic and diastolic pressures. In the survey of 1137 men, the rise in blood pressure was measured during the cold pressor test. This test is likely to be affected if lead were to affect neurogenic mediators of blood pressure. The mean change in systolic pressure was 24 mm Hg and the 95% range was -6 to 60 mm Hg, but there was no evidence of any association with blood lead level.
Baseline and three month change in systemic venous norepinephrine as predictors of clinical outcomes in the BEST trial Michael R. Bristow, R Zelis, R Nuzzo, J Lindenfeld, Brian D. Lowes, M J. Domanski, Eric J. Eichhorn, Heidi J. Krause-Steinrauf, the BEST Trial Investigators N/a. VA Cooperative Clinical Trials Center, Palo Alto, CA, NHLBI, Bethesda, MD
Journal: Journal of the American College of Cardiology (2001)
Precocious Pregnancy.
Authors: None De F. W.
Journal: JAMA (1898)

Philadelphia, July 19, 1898. <h3>To the Editor:</h3> —In reference to your article of July 2, 1898, page 42, I recall a case in 1867 (of which I have notes) of the delivery of a girl ten days before she was twelve years of age. The confinement was normal, but was followed by a phlegmasia alba dolens in both legs. She had been brought up in a house of prostitution, and at the age of eight years had commenced cohabitation with boys. She menstruated at ten, and at the time of delivery, pelvis, mammæ and pubic hair were well developed. I was able afterward to confirm her statement. Her subsequent course was somewhat peculiar. After ten years of the most vicious profligacy she married a staid, quiet farmer, settled down to a life of intensely hard work, and after a number of syphilitic abortions, was so far cured that she raised
Terfenadine once daily in chronic urticaria
Journal: Allergy (1989)

The objective of these three double‐blind multi‐centre studies was to determine whether terfenadine 120 mg once daily has similar efficacy and tolerability as the standard dosage of 60 mg twice daily in the treatment of chronic urticaria. A total of 252 patients were randomly allocated to two parallel groups and treated for 2 weeks with either regimen. Evaluation of efficacy was based on rating scales for investigator and patient, i.e. itch, number of wheals, wheal size and an overall rating of efficacy. A similar improvement was seen in all variables, and there were no statistically significant differences between treatment groups. The power of the studies combined is &gt; 80%, i.e. sufficient to state convincingly that treatment effects are not different. Both treatments were also equally well tolerated.
<i>Darwin and after Darwin. an Exposition of the Darwinian Theory, and a Discussion of Post-Darwinian Questions</i>. By George John Romanrs. M.A., LL.D., F.R.S. Vol. 1, the Darwinian Theory. The Open Court Publishing Company, Chicago, 1892
Authors: J. G. B.
Journal: American Journal of Psychiatry (1892)

to be treated in the uSual way, with bromides, alone or in combination with chloral.Too much mu t not be expected of drugs in cases dependent on organic ksi ns.
Night Shift
Authors: Tom Di Salvo
Journal: Annals of Internal Medicine (1995)

Ad Libitum1 March 1995Night ShiftTom Di Salvo, MDTom Di Salvo, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-5-199503010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the ER tonightAnother gunned addict,Pupils blown as hubcaps,One small hole carefully shotSquare into visual cortex.No exit wound, but bullet raisedA tumor over the temple,Bluish as a ripened cervix,Brains exploded into brains.A bored student bags breathDown the graceful, bruised larynxInto cold, black lungs;A thick rope of gold rises,Falls, slips tighter around the neck.We track his blood across the room.And mothers without tears... Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byP223 - Analyse des comptes-rendus anatomopathologiques de mélanome 1 March 1995Volume 122, Issue 5Page: 391KeywordsAddictsBloodBrainEpileptic seizuresFallsFatsHemorrhageInfantsLarynxLungs ePublished: 15 August 2000 Issue Published: 1 March 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Late‐onset warfarin‐induced skin necrosis: case report and review of the literature
Authors: D.W. Essex, S.S. Wynn, D.K. Jin
Journal: American Journal of Hematology (1998)

Warfarin-induced skin necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced skin necrosis and review the literature on this rarely reported variant of warfarin-induced skin necrosis. The skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C. Am. J. Hematol. 57:233–237, 1998. © 1998 Wiley-Liss, Inc.
Whither the chronic disease hospital?
Authors: A. P. Ruskin
Journal: JAMA (1975)

RECENT legislation has mandated reclassification of chronic disease hospitals as skilled nursing facilities. This has led to governmental efforts to reduce the costs and extent of care rendered in certain instances. Many diseases run a protracted subacute or chronic course, producing symptoms and disabilities that may last for varying lengths of time or for the rest of the patient's life. Many of these conditions involve slow deterioration, with periods of exacerbation alternating with periods of partial remission. Typical of this category would be rheumatoid arthritis, multiple sclerosis, some forms of chronic pulmonary disease, and chronic renal disease. Other conditions produce rapid onset of severe disability and then tend to stabilize, a characteristic condition being the cerebrovascular accident. A third major group is that of congenital diseases and other conditions requiring prolonged rehabilitation efforts and diseases such as muscular dystrophy that cause progressive deterioration. These categories are by no means all-inclusive,
AB0592 SYSTEMIC
Journal: Annals of the Rheumatic Diseases (2019)

Abstract1Peking University Third Hospital, Department of Rheumatology and Immunology, Beijing, China, 2School of Basic Medical Sciences, Peking University, Department of Pathology, Beijing, ChinaBackground Systemic vasculitis involving the breast is a rare clinical condition and may mimic breast cancer or mastitis clinically or radiographically.Objectives In this article, we reported a case of polyarteritis nodosa (PAN) with breast involvement and made a summary on the published cases of systemic vasculitis affecting breasts in order to better understand this disorder.Methods We reported a case of PAN affecting breast and conducted a retrospective review of literatures reporting patients with the diagnosis of systemic vasculitis involving breasts by using MEDLINE, EMBASE, Web of Science, the Cochrane Library, and Scopus database in any language up to June 1st, 2018.Results A case of a 27-year-old female patient presented with a painful mass of the right breast was diagnosed as PAN by the biopsy. After six months of treatment of full dose prednisone and methotrexate, her condition kept stable and inflammatory markers remained normal. A total of 67 cases were included, with granulomatosis with polyangiitis (GPA), giant cell arteritis (GCA) and PAN as the main types. The typical manifestation was mass (79.2%, 53/67) in the breast. All the diagnoses were made according to the pathology of the breast biopsy. Glucocorticoid and immunosuppressant were the main therapies. 74.6% (50/67) patients achieved remission during follow-up.Conclusion In total, we reviewed the clinical features and outcome of 67 cases of the systemic vasculitis involving the breast including the case we reported. Definite diagnosis depends on tissue biopsy, which is important, as the prognosis of diseases is upon to the types of vasculitis.Download figure Open in new tab Download powerpoint Figure 1 Download figure Open in new tab Download powerpoint Figure 2 Disclosure of Interests None declared
Re: Indeterminate 1-2 Cm Nodules Found on Hepatocellular Carcinoma Surveillance: Biopsy for All, Some, or None?
Authors: Korosh Khalili, Morris Sherman
Journal: Hepatology (2011)

We thank Drs. Iavarone and Sangiovanni for the interest in our study,1 but caution the authors with regard to several points in their letter. First, their conclusions are based on a small sample size of 36 indeterminate nodules. While they calculate sensitivity and specificity of 44% and 55%, respectively, using our proposed criteria, the 95% confidence interval was not reported. We calculate their confidence interval to be 21%-69% for sensitivity and 32%-76% for specificity. Small sample sizes lead to real uncertainty. Second, the authors report that 16/35(46%) of their malignant nodules did not demonstrate a typical enhancement pattern on imaging. This rate is well above those for <2 cm nodules reported by Forner et al. (15%),2 Leoni et al. (7%),3 or us (25%).1 The substantial lower sensitivity reported by Iavarone and Sangiovanni may be a result of their small sample size, but should lead to reexamination of their methodology. It is unclear whether the authors used the critical delayed phase in assessment of washout.4 They also used fixed imaging times after contrast injection for all magnetic resonance imaging (MRI) and an indeterminate number of computed tomography (CT) scans, compromising phase timing. Third, we disagree with fine-needle biopsy (FNB) as the reference standard. The substantial false-negative rate of biopsy is ignored by the authors in both their study and their letter. FNB, as opposed to core biopsy, further compromises the diagnosis of very early hepatocellular carcinomas (HCCs) due to its inability to detect architectural changes such as sinusoidal invasion.5 Biopsy relies on the judgment of a pathologist to predict future behavior of a nodule, whereas close imaging follow-up demonstrates actual behavior: growth. For the purposes of a study, long-term stability represents a stronger reference standard than biopsy. Finally, Iavarone and Sangiovanni worry that our proposed criteria may lead to "significantly delayed" diagnosis in a proportion of patients. Our role is detection and treatment of only malignancies that cause morbidity or shorten life. If the term "significant" is to be used outside its statistical definition, it should be within such a framework. In the setting of a competing potentially fatal disease (cirrhosis), the treatment of "very early HCCs" has yet to be justified. We invite the authors and others to perform a new prospective trial to independently evaluate our proposals. Korosh Khalili MD*, Morris Sherman MD , * Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, Department of Gastroenterology, University of Toronto, Toronto, ON, Canada.
Survival benefit associated with the number of chemotherapy/biologic treatment lines in 5,129 metastatic colon cancer patients.
Authors: Nader Hanna, Corinne Woods, Zhiyuan Zheng, Ebere Onukwugha, Brian S. Seal, C. Daniel Mullins
Journal: Journal of Clinical Oncology (2014)

559 Background: The purpose of this study was to investigate the association between multiple chemotherapy/biologic treatment lines and survival among patients diagnosed with metastatic colon cancer (mCC). Methods: Patients aged 66 to 105 years old diagnosed with mCC between 2003 and 2007 were selected for analysis from the Surveillance, Epidemiology and End Results SEER-Medicare data to determine the association between chemotherapy/biologic treatment lines and survival. We examined the survival benefits using Cox proportional-hazards regressions with inverse probability weighting method to adjust for the probability of receiving treatment lines. Results: Patients with no chemotherapy/biologic treatment had an adjusted median survival time of 6.8 months. Each chemotherapy/biologic treatment line received was associated with longer adjusted median survival times: 11.9 months, 23.2 months and 26.4 months for receipt of first-line treatment only, second-line treatment and subsequent treatment, respectively. Colon cancer-specific mortality hazard ratios (HRs) were 0.637, 0.391 and 0.350 (p&lt;0.001 for each) for first-line, second-line and subsequent treatments, respectively. Overall mortality hazard ratios were 0.604, 0.398 and 0.364 (p&lt;0.001 for each) for first-line, second-line and subsequent treatments, respectively. Compared to receiving only first-line treatment, proceeding to second-line treatment was associated with longer colon cancer-specific survival (HR=0.614, p&lt;0.001) and longer overall survival (HR=0.659, p&lt;0.001). Patients with a low-graded tumor had longer colon cancer-specific and overall survival (HR=0.746, p&lt;0.001; HR=0.762, p&lt;0.001, respectively) and lived 5.6 months longer. Factors associated with shorter survival were a higher age category and being female. Conclusions: Among mCC patients who survived at least 3 months from diagnosis, each chemotherapy/biologic treatment line was independently associated with significantly longer survival. Proceeding from first-line to second-line therapy or having a low-graded tumor was also associated with longer survival. Proceeding from second-line third-line therapy showed neither benefit nor harm.