tbuckley/cabot-search huggingface dataset:
A consolidated screening tool for supportive oncology needs and distress.
Authors: Christine B. Weldon, Rosa Berardi, Frank J. Penedo, Jennifer Carrie Obel, Catherine Deamant, James Gerhart, Urjeet Patel, William Dale, Paramjeet Khosla, Colleen Savory, Oana Cristina Danciu, Patricia A. Robinson, Joanna Martin, Julia Rachel Trosman
Journal: Journal of Clinical Oncology (2016)

e21685 Background: The IOM 2013 report recommends supportive oncology care starting at diagnosis and Commission on Cancer standard 3.2 requires distress screening and indicated care. Current screening tools are fragmented and address only a portion of patients’ supportive oncology needs. Integration in clinical flow can be burdensome. Screening and provision of supportive oncology care vary widely across institutions. Methods: A collaborative of 100+ clinicians, funded by The Coleman Foundation, developed a patient-centric consolidated screening tool based on validated instruments (NCCN Distress Problem List, PHQ-4, PROMIS), and IOM 2013 treatment and care concerns. 5 cancer centers piloted the tool and surveyed a sample of patients, providers assessing each patient’s screening results (assessors) and providers receiving referrals. Results: Responders included 29 patients, 81 assessors and 26 providers receiving referrals. A majority found that the tool asked the right questions, but some reported partial relevance (Table). However, 96% (25/26) of assessors reporting partial relevance also uncovered one or more relevant needs for the same patient (p = 0.002). 75% of patients completed the screening tool on their own, 12% with limited help, 5% did not have enough time, 4% could not complete and 3% declined. Completing the screening tool took 10 minutes or less for 78% of patients. The assessors spent less than 5 minutes reviewing the tool results for 76% of patients. 70% of patients would be willing to complete the tool at every visit. Conclusions: A consolidated supportive oncology screening tool is feasible, accepted by and beneficial for most patients and providers to identify distress and supportive oncology needs. As the tool is adopted by collaborating institutions, it is expected to reduce variation and increase consistency in supportive oncology screening and care with implications for national dissemination. Question Patient %, n = 29 Assessor %, n = 77 Referral pro vider %, n = 26 Right questions / uncovered relevant issues for a specific patient 86 84 96 Partial relevance: some questions not important / not relevant to a spe cific patient 48 34 9 I have training or resources to address patient needs NA 90 88
THE RELIEF OF DYSPNEA
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Familiality of the Puerperal Trigger in Bipolar Disorder: Results of a Family Study
Authors: I. Jones
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: Puerperal psychosis, an episode of mania or psychosis precipitated by childbirth, follows approximately one in 1,000 deliveries. The evidence of clinical, outcome, and genetic studies supports the hypothesis that the majority of puerperal psychotic episodes are manifestations of an affective disorder diathesis with a puerperal trigger. Family studies of puerperal psychosis consistently demonstrate familial aggregation of psychiatric (particularly affective) disorder and suggest a major overlap in the familial factors predisposing to puerperal psychosis and bipolar disorder. The single large study that used direct interview of relatives suggested that familial factors play a role in vulnerability to puerperal triggering itself. The authors’ goal was to test this hypothesis further. METHOD: They conducted a study of the occurrence of episodes of puerperal psychosis in families multiply affected with bipolar disorder participating in an ongoing molecular genetic study of bipolar disorder in sibling pairs. RESULTS: Episodes of puerperal psychosis followed 81 (26%) of 313 deliveries to 152 parous women with bipolar disorder, 58 (38%) of whom had at least one puerperal psychotic episode. Puerperal episodes clustered in families. Episodes of puerperal psychosis occurred in 74% (N=20) of the 27 parous women with bipolar disorder who had a family history of puerperal psychosis in a first-degree relative but in only 30% (N=38) of the 125 women with bipolar disorder with no such family history. CONCLUSIONS: These results conclusively demonstrate that familial (probably genetic) factors are implicated in susceptibility to triggering of puerperal episodes in women with bipolar disorder. These findings have implications for future research and will be of use clinically in the management of women with bipolar disorder who are considering pregnancy.
The role of compulsiveness in the normal physician
Authors: G. O. Gabbard
Journal: JAMA (1985)

This article presents some observations from a workshop setting about the role of compulsiveness in the normal physician. Case examples illustrate the effect of this character trait on the professional, personal, and family life of the typical physician. Doubt, guilt feelings, and an exaggerated sense of responsibility form a compulsive triad in the personality of the physician. This triad manifests itself in both adaptive and maladaptive ways. This article focuses primarily on the maladaptive, including difficulty in relaxing, reluctance to take vacations from work, problems in allocating time to family, an inappropriate and excessive sense of responsibility for things beyond one's control, chronic feelings of "not doing enough," difficulty setting limits, hypertrophied guilt feelings that interfere with the healthy pursuit of pleasure, and the confusion of selfishness with healthy self-interest. (<i>JAMA</i>1985;254:2926-2929)
Primary Amyloidosis
Authors: WERNER F. BARTH
Journal: Annals of Internal Medicine (1968)

Great progress has been made in defining the structure of amyloid. Further studies of the ultrastructure and composition of amyloid are described. Clinical and immunochemical studies on 15 patients with primary amyloidosis are presented. These studies do not support a direct relation between immunoglobulins, particularly Bence Jones proteins, and amyloidosis. Low immunoglobulin levels in these patients were frequently noted and reflected decreased synthesis, urinary or gastrointestinal loss, or all of these. Peripheral vascular blood flow was measured in several patients, two of whom suffered from intermittent claudication. Both of these patients had a decreased vasodilator response to ischemia and exercise apparently due to extensive vascular amyloid. On the basis of studies presented here and other recent studies, an alternate hypothesis for the pathogenesis of primary amyloidosis is presented.
Abstract 3145: Detection of premature aging among adolescent and young adult osteosarcoma and Ewings sarcoma survivors
Authors: Laurence H. Baker, Denise Reinke, Philip Boonstra, Erin Peregrine Antalis
Journal: Cancer Research (2019)

Abstract BACKGROUND Bone sarcoma survivors are at high risk for multiple chronic diseases at a young age, which can be characterized as premature aging. Bone sarcoma survivors have the highest cumulative incidence of multiple serious chronic conditions according to analysis of the Childhood Cancer Survivor Study 1. Cardiovascular biomarkers can be used to detect CAD, and enable early intervention in asymptomatic patients. METHODS Patients are seen annually at the Sarcoma Survivorship Clinic at the University of Michigan and includes high risk patients over the age of 18 who are at least two years free of disease after treatment completion. Clinical data includes: Blood Pressure, BMI, lipid profile, high sensitivity C-Reactive Protein, and imaging. RESULTS 30% of patients aged 18-39 exhibit elevations in the cardiovascular biomarker hsCRP, in addition to the traditional biologic markers of elevated lipids, hypertension, and BMI at their most recent clinic visit (Table 1). A subset of patients independently evaluated by 2 nuclear cardiologists also show evidence of coronary artery calcifications (CAC), which is considered pathognomonic of CAD. 40% have been diagnosed with 2 or more of the following chronic diseases: dyslipidemia, obesity, renal insufficiency, anxiety and/or depression, pulmonary disease, cardiovascular disease, thyroid dysfunction, hypertension, liver disease, and anemia. CONCLUSION The overall cardiac risk profile among high risk bone sarcoma survivors is characteristic of premature aging. Examining the underlying mechanism of premature aging is essential in this population. Proposed investigation includes alteration of immune pathway as effected by diet, the microbiome, metabolomics, and cellular senescence. REFERENCES: 1. Gibson TM et al: Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970-99: a report from the Childhood Cancer Survivor Study cohort. The Lancet Oncology 2045:1-12, 2018 Characteristics of bone sarcoma survivors, aged 18-39 (n=20)Chronic Disease Diagnosis%1502253+15Cardiovascular biomarkershsCRP ≥ 2.030BMI ≥ 3015Cholesterol ≥ 200 mg/dL12Hypertension ≥130/8015Glucose ≥ 100 mg/dL20CAC&amp;gt;015 Citation Format: Laurence H. Baker, Denise Reinke, Philip Boonstra, Erin Peregrine Antalis. Detection of premature aging among adolescent and young adult osteosarcoma and Ewings sarcoma survivors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3145.
斑块状银屑病的生物治疗顺序:基于来自BioCAPTURE的10年荷兰实际证据的成本效用分析
Authors: S.L. Klijn, J.M.P.A. van den Reek, G. van de Wetering, A. van der Kolk, E.M.G.J. de Jong, W. Kievit
Journal: British Journal of Dermatology (2018)

银屑病是一种慢性炎症性皮肤病。这种病会造成不美观和不适问题,严重影响生活质量。常见的治疗方法是定期涂抹药膏,但较严重的银屑病需要口服或注射免疫抑制药物。新型的靶向“生物”药物更有效,但非常昂贵。因此,成本效用数据有限。实际生活中的患者通常与入选随机对照试验(RCT)的患者在额外疾病方面有差异,他们通常会更换药物来改善效力或降低副作用;临床医生无从得知使用这些药物的顺序。这项来自荷兰、由行业发起的研究分析了三种生物药物(阿达木单抗、依那西普和优特克诺)在10年内以不同顺序使用的成本效益。计算机模拟使用了有关药物和控制成本的公开信息以及来自已在荷兰登记处BioCAPTURE(生物制剂治疗银屑病而使用登记持续评估)注册的318名患者的“实际证据”,其中包括生活质量评分以及临床成果(即症状)和治疗细节。患者注册时的平均年龄为47岁,平均体重为87 kg,平均生物疗程时长为29.6个月。他们估算,每位患者使用这些生物制剂治疗银屑病的十年成本为141962至148442欧元。对于每延长一年实现完全康复,先使用阿达木单抗或优特克单抗(而不是依那西普)的成本较低,甚至是在使用更便宜的“生物仿制药”建模的情况下。因此,从健康经济角度来说,这种顺序更为有利,至少在学术中心如此。
AMA Insights
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Korea University Medical Library JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Correction: Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion
Authors: Xiaoyuan Huang, Xiangyang Bai, Yang Cao, Jingyi Wu, Mei Huang, Duozhuang Tang, Si Tao, Tao Zhu, Yanling Liu, Yang Yang, Xiaoxi Zhou, Yanxia Zhao, Mingfu Wu, Juncheng Wei, Daowen Wang, Gang Xu, Shixuan Wang, Ding Ma, Jianfeng Zhou
Journal: The Journal of Experimental Medicine (2021)
THE BRITISH CONGRESS ON TUBERCULOSIS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculosis
Authors: Theodore L. Badger
Journal: New England Journal of Medicine (1959)

(Concluded)ChemoprophylaxisChemoprophylaxis is experiencing wider recognition. It was discussed by the panel† on this subject at the Deborah International Symposium on Tuberculosis on November 20, 1958, in Philadelphia.65 There, it was made clear that chemoprophylaxis should properly be considered in two ways: Primary prophylaxis, or drug therapy with isoniazid before tuberculous infection has occurred. Secondary prophylaxis, or isoniazid treatment after infection has occurred.Strictly speaking, by definition, prophylaxis66 means "the preventing of disease" — from the Greek, "take precautions against" — "before" infection, or "defending or protecting from disease." Thus, so-called primary prophylaxis before infection has occurred is the . . .
Error in Survival Percentage.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Royal Medical and Chirurgical Society: May 9, 1843
Journal: BMJ (1843)

guineas from the select vestry, were naturally anxious for the continuation of the subscription, fearing that the number of applicants for dis- pensary relief!-already considerably exceeding 50,000 annually!! might be diminished by the withdrawal of the customary allowance.In this emergency they applied to their medical board, (i.e. the honorary officers,) for their opinion; the medical board summoned the stipendiary surgeons, nine in number, that they might go through the farce of giving their opinions, which, as the sequel
Premedical Education
Authors: Richard I. Haddy
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The letter entitled "Premedical Education" by Martha L. Elks, MD, PhD (1981;245:32), was interesting and probably based on considerable experience with the subject. As an undergraduate chemistry and biology major, I must admit that there are times I think that my education as a whole is too narrow and wish I had more exposure to the humanities and other nonscience subjects. However, I believe I should point out that I and at least some of my undergraduate colleagues were science majors because (in addition to being interested in our subjects) we honestly thought at that time that a strong science background would make us better physicians—and not because we thought it would help us get into medical school. I still believe my science background occasionally helps me understand current medical concepts that I would not otherwise be able to comprehend. Further, in majoring in chemistry I recall
Comparing Tobacco Cigarette Dependence With Other Drug Dependencies
Authors: Lynn T. Kozlowski
Journal: JAMA (1989)

About 1000 persons seeking treatment for alcohol or drug dependence were asked, relative to cigarettes, about the difficulty of quitting the use of the substance for which they were seeking treatment, the strength of their strongest urges to use, and the pleasure they derived from use. Fifty-seven percent said that cigarettes would be harder to quit using than their problem substance. These ratings were related to the level of cigarette dependence and the perceived difficulty of quitting the use of the problem substance. The alcohol-dependent persons were about four times more likely than the drug-dependent persons to say that their strongest urges for cigarettes were at least as great as their strongest urges for their problem substance. Cigarettes were generally rated as less pleasurable than alcohol or other drugs. Thus, experiential experts on dependence judge cigarette dependence as at least as "addictive" as other drug use, but not as pleasurable, indicating important similarities and differences between cigarette dependence and other forms of dependence on psychoactive substances. (<i>JAMA</i>1989;261:898-901)
TOPICS OF THE WEEK.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acquired immunodeficiency syndrome in low-incidence areas. How safe is unsafe sex?
Authors: D. W. Fleming
Journal: JAMA (1987)

Serum specimens from the cohort of persons who attended sexually transmitted disease clinics in New Mexico during a two-month period were tested for human immunodeficiency virus (HIV) antibody. Twenty-seven (2.0%) of 1374 serum specimens had repeatedly low-positive reactions by enzyme-linked immunosorbent assay testing, and 22 (1.6%) had repeatedly high-positive reactions. All sera (sufficient for testing by Western blot) with low-positive reactions gave negative results, and all sera (sufficient for testing by Western blot) with high-positive reactions gave positive results. All persons whose serum had high-positive reactions were male. Most (86%) had been seen at the only urban sexually transmitted disease clinic in New Mexico, and most (72%) were openly gay or bisexual. Of all gay and bisexual men evaluated, 14% (16/112) had high-positive reactions. Rapid plasma reagin positivity was significantly associated with HIV enzyme-linked immunosorbent assay low (false) positivity. The relatively high rate of HIV seropositivity among gay men with other sexually transmitted diseases indicates that transmission of acquired immunodeficiency syndrome is continuing in this low-incidence area and documents the need for testing and counseling programs in sexually transmitted disease clinics. (<i>JAMA</i>1987;258:785-787)
Acute Pancreatitis
Authors: Chris E. Forsmark, Santhi Swaroop Vege, C. Mel Wilcox
Journal: New England Journal of Medicine (2016)

This review summarizes recent changes in the management of acute pancreatitis, encompassing fluid resuscitation, antibiotic use, nutritional support, and treatment of necrosis, and also addresses common misunderstandings and areas of controversy.
Editorial: Noise in hospital.
Authors: Medical Jornal
Journal: BMJ (1973)

Noise in HospitalRecently there has been an altogether laudable and increasing concern about pollution of the countryside by motorways, motor-cars, mineral exploration, and the like; about pollution of water, rivers, and seas by dangerous effluents or dumping of chemicals; and about pollution of the air by factories, radio- active matter, and smokers.People unfortunate enough to live near an airport have also had cause for complaint about pollu- tion by noise.But not enough has been said about pollution by noise in hospital.Our patients could say much about the banging of doors, the rumble of lifts, the rattle of ill-maintained trolleys, the clatter from the kitchen and the sluice or service rooms, the chatter of visitors, the tapping of nurses' and doctors' heels, and the snores, groans, or flatus of fellow patients.The effect is worse if the sounds arouse fear, as groans and cries may.How much consideration is given to ambient noise in relation to the siting of new hospitals ?The roar of heavy traffic outside a hospital ward may be disturbing to patients, and the reduction of noise by double-glazing of windows may be forbidden on the ground of cost.But not all hospitals have given thought to the use of sound-proof tiles or sound-deadening walls and floors.Some parts of a hospital are much noisier than others.R. Gadeke and colleagues' recorded the noise level in child-