Metabolic Markers of Insulin Resistance in Overweight Persons
Authors: Tracey McLaughlin, Gerald Reaven
Journal: Annals of Internal Medicine (2004)

Letters3 August 2004Metabolic Markers of Insulin Resistance in Overweight PersonsTracey McLaughlin, MD and Gerald Reaven, MDTracey McLaughlin, MDFrom Stanford University School of Medicine, Stanford, CA 94305-5103.Search for more papers by this author and Gerald Reaven, MDFrom Stanford University School of Medicine, Stanford, CA 94305-5103.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-3-200408030-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We are concerned that Dr. Rizvi feels our recent report will sidetrack and confuse health care professionals. Obviously, that was not our intent. The purpose of our analysis was to make the important clinical point that not all overweight or obese individuals are at equal risk for serious health consequences (1), particularly type 2 diabetes mellitus and CVD. Given this difference in risk, the current obesity epidemic, and the difficulty in achieving weight loss, we thought it would be helpful to describe a relatively simple way to identify the apparently healthy overweight or obese person who would benefit ...References1. Reaven GM. Importance of identifying the overweight patient who will benefit the most by losing weight. Ann Intern Med. 2003;138:420-3. [PMID: 12614095] LinkGoogle Scholar2. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-607. [PMID: 3056758] CrossrefMedlineGoogle Scholar3. Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, et al . Insulin resistance and insulin secretory dysfunction as precursors of non–insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med. 1993;329:1988-92. [PMID: 8247074] CrossrefMedlineGoogle Scholar4. Yip J, Facchini FS, Reaven GM. Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab. 1998;83:2773-6. [PMID: 9709945] CrossrefMedlineGoogle Scholar5. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285:2486-97. [PMID: 11368702] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Stanford University School of Medicine, Stanford, CA 94305-5103. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImportance of Identifying the Overweight Patient Who Will Benefit the Most by Losing Weight Gerald M. Reaven Use of Metabolic Markers To Identify Overweight Individuals Who Are Insulin Resistant Tracey McLaughlin , Fahim Abbasi , Karen Cheal , James Chu , Cindy Lamendola , and Gerald Reaven Metabolic Markers of Insulin Resistance in Overweight Persons Ali A. Rizvi Metrics 3 August 2004Volume 141, Issue 3Page: 243-244KeywordsAdenosine triphosphateAttentionCardiovascular diseasesInsulin resistanceMedical risk factorsMetabolic syndromeOverweightRisk assessmentsType 2 diabetesWeight loss ePublished: 3 August 2004 Issue Published: 3 August 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...