tbuckley/cabot-search huggingface dataset:
9/11 Firefighters at Risk for Multiple Myeloma
Journal: Cancer Discovery (2018)

The largest study to date of responders to the World Trade Center attacks in New York, NY, on 9/11 reports that exposed firefighters have roughly twice the risk of developing multiple myeloma precursor disease as the general population. Moreover, firefighters who go on to develop multiple myeloma exhibit a younger age of onset and more aggressive disease than is typical.
Evidence of increased guanylate cyclase activation by acetylcysteine in fulminant hepatic failure
Authors: P Harrison, J Wendon, R Williams
Journal: Hepatology (1996)

Patients with fulminant hepatic failure (FHF) have a severe microcirculatory disturbance causing tissue hypoxia. Infusion of acetylcysteine improves survival and reduces the incidence of multiorgan failure by enhancing tissue oxygenation. Because the observed circulatory effects of acetylcysteine in FHF are similar to and synergistic with those produced by the microcirculatory vasodilator prostacyclin, we postulated that acetylcysteine might potentiate an endogenous vasodilator. Nitric oxide, a vasodilator that activates soluble guanylate cyclase, is a possible candidate as plasma cyclic 3′,5′-guanosine monophosphate (cGMP) is raised in FHF, and in vitro acetylcysteine has been found to enhance soluble guanylate cyclase activity. To investigate this possible mechanism further, plasma cGMP was measured before and after acetylcysteine infusion in 24 patients with FHF and again in 6 patients after recovery from acute illness. cGMP levels were high in FHF during acute illness (median, 7.0 nmol/L [interquartile range, 2.6-10.0]) in comparison with levels taken after recovery (1.5 nmol/L [1.0-1.9]; P &lt; .05). Levels rose further after acetylcysteine infusion in the FHF cases (mean increase, 204% [95% CI; 49 to +360]; P &lt; .01) but not in the cases after recovery (38% [-7 to +84]). There were no significant changes in levels of plasma atrial natriuretic peptide (ANP) or cyclic adenosine monophosphate (cAMP) (mean increases, 8% [-6 to +22] and 17% [-9 to +43], respectively). The findings further support the hypothesis that the beneficial hemodynamic effects of acetylcysteine in FHF are mediated by enhancing the activity of the nitric oxide/soluble guanylate cyclase enzyme system.
MISCELLANEOUS.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue Access Provided by Sookmyung Women’s University JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account
Studies on Populations Exposed to Polychlorinated Biphenyls
Authors: Kathleen Kreiss
Journal: Environmental Health Perspectives (1985)

Mean serum levels of polychlorinated biphenyls (PCBs) in U.S. population groups without occupational exposure to PCBs are usually between 4 and 8 ng/mL, with 95% of individuals having serum PCB measurements of less than 20. Subpopulations consuming fish taken from contaminated waters, such as Lake Michigan and near Triana, AL, have mean serum PCB levels several times those found in other general population groups and ranges that extend into concentrations found in industrial populations involved in capacitor manufacture. Two studies of general populations and several studies of industrial workers have demonstrated associations of PCBs with various serum lipids and liver enzyme levels. Six groups of investigators have found associations between PCB or chlorinated pesticide levels and blood pressure. Research efforts are needed in clarifying determinants of serum-adipose partition ratios; the utility of urinary porphyrins as a measure of subclinical hepatic effects; human metabolites and excretion of chlorinated hydrocarbons; and the relation, if any, between blood pressure and organochlorine compounds when controlled for confounding variables. Established cohorts, such as those in Triana, Lake Michigan sportsfishers, the Michigan PBB cohort, residents of farms with PCB-lined silos, and occupational groups, could all be studied further with attention to these research questions.
Klinische Wochenschrift, Berlin
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The psychedelic plague and polypsychotropia
Authors: P. T. Donlon
Journal: JAMA (1971)

Mankind has experienced numerous plagues throughout history. Often the morbidity seriously hampered the functioning of the stricken society. Most frequently, the physicians of antiquity were unable to successfully treat or prevent the spread of the plagues. They had to experience the anguish and frustration of observing the disease run its natural course. Multiple causative factors were responsible for the origins of the plagues. Among them were such social problems as population overcrowding and inadequate sanitation. Thus any treatment program would have required both the recognition and correction of the social causative factors as well as development of medical cures for those who became diseased. In the past decade the Western world has experienced a new plague. It too has placed a great social and financial burden on society. This plague differs notably from previous ones in two ways. First, the noxious agent is not an infectious disease but a series
Pulmonary toxicity of thioureas in the rat.
Authors: A M Scott, G M Powell, D G Upshall, C G Curtis
Journal: Environmental Health Perspectives (1990)

Administration of alpha-naphthylthiourea (ANTU) to rats causes damage to pulmonary endothelial cells and possibly mesothelial lining cells that together may account for the massive pleural effusion characteristic of thiourea toxicity. Using 35S-thiourea as a model compound, the extent of binding of 35S to lung proteins correlated well with the extent of edema, suggesting that the extent of binding of thiourea metabolites is a measure of lung toxicity. ANTU and phenylthiourea (PTU) compete for 35S binding to lung slices, suggesting that these toxins may act in a similar way. Binding of 35S in lung slices from resistant rats is much less than in controls, and resistance cannot be explained by differences in either whole body metabolism or redistribution of thiourea in vivo. Lung glutathione levels (in vitro and in vivo) in normal and resistant rats following thiourea administration were essentially the same. However, at doses of thiourea that cause pleural effusion, there was an increase in total lung glutathione.
"MARCHAND'S ADRENALS"—A NEW MAMMALIAN ORGAN.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Lectures on some Points Connected with the Treatment of Wounds
Authors: W. Macewen
Journal: BMJ (1881)

Jan. 2% x88i.disease (in India) as always of f.ical origin, should give the subject reconsideration.In Virchow's fibrinous or diphtheritic form, or in gangrenous dysentery, the changes are more serious.The intestine is intensely
The two faces of pathogenic Escherichia coli
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eboard
Authors: Walter Fitch, Masatoshi Nei, Marcy Uyenoyama, Elizabeth Raffaele, G Golding, Richard Lewontin, Howard Ochman, Michael Lynch, Jody Hey, Paul Sharp, Jianzhi Zhang, John Archibald, Laura Landweber, Ziheng Yang, Dan Graur
Journal: Molecular Biology and Evolution (2010)
PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells
Authors: Claire E. Moore, Omotola Omikorede, Edith Gomez, Gary B. Willars, Terence P. Herbert
Journal: Endocrine Reviews (2011)

PKR-like ER kinase (PERK) is activated at physiologically low glucose concentrations in pancreaticβ-cells. However, the molecular mechanisms by which PERK is activated under these conditions and its role inβ-cell function are poorly understood. In this report, we investigated, in dispersed rat islets of Langerhans and mouse insulinoma-6 (MIN6) cells, the relationship between extracellular glucose concentration, the free endoplasmic reticulum (ER) calcium concentration ([Ca2+]ER) measured directly using an ER targeted fluorescence resonance energy transfer-based calcium sensor, and the activation of PERK. We found that a decrease in glucose concentration leads to a concentration-dependent reduction in ([Ca2+]ER) that parallels the activation of PERK and the phosphorylation of its substrate eukaryotic initiation factor-2α. We provide evidence that this decrease in ([Ca2+]ER) is caused by a decrease in sarcoplasmic/ER Ca2+–ATPase pump activity mediated by a reduction in the energy status of the cell. Importantly, we also report that PERK-dependent eukaryotic initiation factor- 2α phosphorylation at low glucose concentration plays a significant role in 1) the regulation of both proinsulin and global protein synthesis, 2) cell viability, and 3) conferring preemptive cytoprotection against ER stress. Taken together, these results provide evidence that a decrease in the ATP/energy status of the cell in response to a decrease in glucose concentration results in sarcoplasmic/ER Ca2+–ATPase pump inhibition, the efflux of Ca2+ from the ER, and the activation of PERK, which plays an important role in both pancreatic β-cell function and survival.
Reports of the Committee for the Investigation of the Causes of Dental Disease. I. The Structure of Teeth in Relation to Dental Disease.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pericardial Endometriosis
Authors: David M. Sensenig
Journal: JAMA (1966)

Pericardial splenosis has been produced in dogs by a number of investigators. The placement of autogenous slices of spleen on the heart by Leighninger et al<sup>1</sup>resulted in positive takes and increased coronary artery backflow. These investigators found that spleen grafts have limited viability and no power for growth and development of an independent blood supply. This procedure has not been adopted clinically as a method of augmenting myocardial blood supply in cases of coronary atherosclerosis. We thought it would be of interest to attempt the experimental production of pericardial endometriosis. It is possible that endometrium growing in this ectopic location might result in an increased blood supply to the heart. Our survey of the literature failed to reveal a similar study. Endometriosis has been experimentally produced by a number of investigators. Jacobson<sup>2</sup>has shown by experimental work in rabbits and monkeys that uterine mucosa will grow on
Obituaries
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Principles and Practice of Roentgen Therapy.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Pathology, Diagnosis, and Treatment of Cardiac Diseases
Authors: W. O. Markham
Journal: BMJ (1859)

A.-GJENERZAL SY-MPTOMS OF PERICAnMITIS.TiHE ,eneral s'nmptoms attending acute pericarditis vary con- siderably.They are, as might be supposed, for the most part, merged in the symptoms of the particular inflammatory, or other disease, with which the pericarditis happens to be associ- ated.The pericarditis of rheumatic fever, indeed, often supervenes in thie progress of the fever without in any degree adding to or altering the general symptoms of it.Sometimes, but not always, local pain, and a feeling of oppression about the region of the heart, point to that organ as the part upon which the inflaimmation has fallen.Every stethoscopist is aware that as a ,eneral rule, it is by the physical signs-the friction sounds -that we gain the earliest intimation of the existence of the pericarditis ; a fact which shows how important it is ever care- fully to watch for these signs during the progress of all those diseases in which, as experience teaches us, pericarditis may possibly arise.Moreover, in severe cases of pericarditis, inflammation of other parts and organs frequently coexist--endocarditis, pleuritis.and pneumonia, for example-and necessarily modify and complicate the character of the symptoms.Hence we may conclude that there are no general symptoms which can be considered as special indicators of the existence of pericarditis.In advanced periods of the disease, however, where the inflam- mation has been severe, and its products are considerable, general, as well as local, indications of serious impediments to the respiratory and circulating organs arise.The symptoms here given are such as are usually met with in a typical case of rheumatic pericarditis.Thle pulse at the wrist varies much in its characters, for the most part corresponding to the nature of the heart's impulse.At first hard, frequent and strong, it becomes weak, fluttering, and irregular in the latter stage of the disease, when the pericardial effusion is large.Sometimes it remains of a natural strength, even when the impulse of the heart is hardly perceptible; or it may be very wealk when the heart's impulse is violent, in which case we may * It has been thought that in Bright's disease of the kidney the head symptoms do not depend upon the urea in the blood, but upon the antemic.
Association News.
Authors: Wm. E. Darnall
Journal: JAMA (1904)

<h3>ATLANTIC CITY HOTELS.</h3><h3>A List of the Hotels and Prices—Ample Accommodation for All.</h3> Atlantic City has about 1,200 hotels and boarding houses. Out of these the committee has selected the following houses, with their rates appended, which they can recommend. Comfortable board may be obtained in Atlantic City from $1 per day upward. The minimum rates apply to single rooms without baths, while the per capita rate per day for double rooms in most cases can be slightly reduced when two occupy the same room. For those wishing accommodations on the European plan, the Dunlop and Young's Hotel are exclusively European; the Grand Atlantic, the Wiltshire, the Garden, the Islesworth, and the Rudolf, furnish accommodations on either European or American plans. The prices given below cover the American plan, except those referring to the Dunlop and Young's Hotel. In order to get good accommodations engagements for rooms should be made
AASLD program
Authors: Andrew Burroughs, Timothy Mccashland, Douglas Hanto, Nancy Ascher, Andres Blei, Ronald Busuttil, Mark Ghobrial, Alan Langnas, Philippe Mathurin, Geoffrey Mccaughan, Santiago Munoz, Peter Neuhaus, John Roberts, Michael Charlton, James Neuberger, Adrian Di Bisceglie, Kris Kowdley, Simon Horslen, Michael Narkewicz, Stuart Tanner, Estella Alonso, John Bucuvalas, Maureen Jonas, Ross Shepherd, Stephen Harrison, Patricia Robuck, Teresa Wright, Coleman Smith, Mindie Nguyen, Willis Maddrey, Judith Podskalny, Imtiaz Alam, John Vierling, Marion Peters, Charles Howell, James Gorham, James Crawford, Margaret Koziel, T Liang, Geoffrey Dusheiko, Anna Lok, Arun Sanyal, Craig Mcclain, Jacquelyn Maher, Arthur Mccullough, Anna Diehl, Fred Poordad, Frank Anania, E Heathcote, Dwain Thiele, Kirsten Boberg, Keith Lindor, Ulrika Broome
Journal: Hepatology (2005)

Understand the problems associated with different types of liver grafts and their potential recipients.• Recognize difficult patient scenarios and identify which pretransplant factors impact long-term outcomes.• Learn the cardinal issues in preventing and managing renal and cardiac problems, and surveillance for neoplasia.This course will highlight current problems and controversies in liver transplantation with regard to the selection of donors and recipients, and current management of specific complications during follow-up.
Pulmonary Edema Following Ingestion of Hydrochlorothiazide
Authors: Alfred D. Steinberg
Journal: JAMA (1968)

Pulmonary edema developed in two women (44 and 65 years of age) within 45 minutes after they had ingested single 50-mg tablets of hydrochlorothiazide. There was no history of heart disease, and the drug was taken for weight reduction in one patient and for mild hypertension in the other. On admission to the hospital, x-ray films of the chest showed congestive changes in the lungs. The arm-to-tongue circulation time was normal. Clinical and laboratory data did not support a diagnosis of myocardial infarction or pulmonary embolus. It is postulated that these were idiosyncratic reactions to the drug.