tbuckley/cabot-search huggingface dataset:
Annales Chirurgiae et Gynaec Fenniae, Helsinki
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
State and Local Influenza Immunization Program Activities
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Overseas aid.
Authors: G Ashcroft, J Corsellis, J Douglas, J Gibson, D Glass, H Jones, G Harris, M Lader, Aubrey Lewis, W Lishman, W Millar, W Paton, L Penrose, Cyril Rashbass, Geoffrey Rose, G Russell, M Rutter, Peter Sainsbury, F Kradpl Taylor, J Tizard, Ian Sutherland
Journal: BMJ (1969)
Repeatability and reproducibility of multiparametric magnetic resonance imaging of the liver
Authors: H. Wilman, J. Jacobs, R. Newbould, M. Halberstadt, M. Gyngell, A. Herlihy, C. Fernandes, C. Kelly, M. Maguire, N. Jayaratne, S. Linden, K. Groves, V. Bachtiar, A. Mckay, M. Kelly, S. Neubauer, R. Banerjee
Journal: Journal of Hepatology (2018)
MUC1/HER2/neu peptide-based immunotherapeutic vaccines for breast adenocarcinomas.
Authors: M. S. Block, V. Suman, M. L. Kosel, S. Markovic, D. W. Northfelt, P. Mukherjee, A. E. McCullough, B. A. Pockaj, W. K. Nevala, J. N. Ingle, E. A. Perez, S. J. Gendler
Journal: Journal of Clinical Oncology (2011)

e13046 Background: Vaccination of resected breast cancer patients has shown promise in prolonging disease-free survival, but immune responses to vaccine antigens have been inconsistent. We hypothesized that addition of the toll-like receptor 9 agonist CpG-7909 and granulocyte-macrophage colony stimulating factor (GM-CSF—sargramostim) to a peptide vaccine for resected breast cancer patients would increase the frequency of vaccine-specific cytotoxic T lymphocytes generated by patients in response to vaccination. Methods: Patients with resected MUC1-positive breast adenocarcinoma who had completed all standard adjuvant therapy were randomized to receive vaccines consisting of three MUC1- and HER-2/neu-derived peptides emulsified in Montanide ISA-51 with varying immune adjuvants: GM-CSF (Arm A); CpG-7909 (Arm B); or both GM-CSF and CpG-7909 (Arm C). Vaccines were given every four weeks for six treatment cycles; patients were then observed for an additional 18 months. Vaccine immune responses were monitored by staining peripheral blood samples with MHC tetramers containing the peptides of interest. Responses were defined as doubling of antigen-specific T cells from pre-treatment levels or conversion from undetectable (< 0.05%) to detectable frequencies of antigen-specific T cells. Results: Four patients experienced ≥ grade 3 toxicities: 1/16 in Arm A (skin infection), 2/11 in Arm B (injection site reaction, endocrinopathy), and 1/12 in Arm C (syncope). The most common toxicities of any grade were injection site reactions, arthralgias, myalgias, and fatigue. HER-2/neu-specific immune responses were induced in 10 of 15 patients tested (3 of 5 in Arm A, 3 of 5 in Arm B, and 4 of 5 in Arm C), while MUC1-specific immune responses were induced in 9 of 15 patients (1 of 5 in Arm A, 4 of 5 in Arm B, and 4 of 5 in Arm C). Conclusions: Vaccines consisting of MUC1 and HER-2/neu peptides with GM-CSF and/or CpG-7909 are generally well-tolerated and lead to T cell immune responses in the majority of vaccinated patients. Funded by the DOD Breast Cancer Research Program DAMD17-01-1-0318.
Truth as a Living Organism
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Informatics
Authors: Donald A. B. Lindberg
Journal: JAMA (1996)

Since our review last year,<sup>1</sup>3 applications of medical informatics have seen substantial progress: computer-based patient records,<sup>2</sup>telemedicine,<sup>3</sup>and electronic biomedical publishing.<sup>4</sup>The evidence lies not only in technical advances but also in heightened commercial activity and in efforts to address related public policy issues. Development was accelerated by the national information infrastructure,<sup>5</sup>most visible in the expanding Internet and its now dominant World Wide Web.<sup>6</sup>Users anywhere on the Internet now get information and computing services from Web sites on computers in many different places. New programming languages, such as Java and Python, even allow users to download "executable code," in a sense turning the idea of computer viruses in a useful direction—and potentially reducing the amount of computing power needed in individual user workstations. Despite years of work,<sup>7</sup>lack of a business case for investments in computer-based patient record systems, telemedicine
Bacterial contamination of skin used as a biological dressing. A potential hazard
Authors: W. W. Monafo
Journal: JAMA (1976)

Bacterially contaminated skin used as a biological dressing on burn wounds can cause serious or even lethal infections, three examples of which are cited. Cadaver-skin allografts were frequently found to contain pathogenic bacteria. The frequency of infections due to the use of contaminated skin grafts on open wounds is unknown. (<i>JAMA</i>235:1248-1249, 1976)
Cyclophosphamide, Bortezomib and Dexamethasone (CVD) Therapy in AL Amyloidosis Is Associated with High Clonal Response Rates and Prolonged Progression Free Survival,
Authors: Christopher P. Venner, Julian D Gillmore, Thirusha Lane, Darren Foard, Lisa Rannigan, Simon DJ Gibbs, Jennifer Pinney, Carol Whelan, Helen Lachmann, Philip N Hawkins, Ashutosh Wechalekar
Journal: Blood (2011)
Women's health and clinical trials
Authors: L. Schiebinger
Journal: Journal of Clinical Investigation (2003)

Women have traditionally been underrepresented in clinical trials. In order to translate recent advances in our understanding of the molecular and physiological bases of sex differences into new therapeutics and health practices, sound sex-specific clinical data are imperative. Since the founding of the Office of Research on Women’s Health within the Office of the Director at the NIH in 1990, inequities in federally funded biomedical research, diagnosis, and treatment of diseases affecting women in the US have been reviewed. Discussed herein is the evolution of gender-related research innovations, primarily within the last decade, and strategies and challenges involved in the success of this recent development.
Coffee, tea, and plasma cholesterol: the Jerusalem Lipid Research Clinic prevalence study
Journal: BMJ (1985)

margarine accounted for 29% of the total variation in 25-OHD concentrations (p <005).Vitamin supplements considered alone significantly affected the total variation in 25-OHD concentrations, but margarine did not.Only 22 (18%) Asians (mostly women) took vitamin supplements and ate margarine.Table IV shows that the largest group (43%') ate margarine but did not take vitamin supple- ments and 31%o did not consume either.
ENZYMES AND THEIR COMMERCIAL EXPLOITATION.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
J Laboratory &amp;amp; Clinical Medicine, St. Louis
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Propoxyphene Pellets
Authors: E. William Kean
Journal: JAMA (1973)

<h3>To the Editor.—</h3> While forged prescriptions are a constant menace to pharmacists, this letter seeks to alert your readers to a possible new problem. When propoxyphene preparations (the Darvon compounds) were introduced 17 years ago the capsule contained a white powder (mild or inert ingredients) and a pink pellet (the propoxyphene). Drug abusers discovered that the pink pellet could be dissolved in a little water in a spoon. By mainlining this solution a "high" could be attained. Darvon quickly became a very attractive drug to abusers. On Feb 9, 1971 the Drug House (a wholesaler of prescription drugs) of Wilmington, Del, was held-up at gun point. One hundred and seventy-five bottles (500 capsules per bottle) of Darvon Compound 65 were stolen: no amphetamines, barbiturates, or narcotics were removed. It was thought that the robbers were professionals out to fill an order for Darvon. Even walkie-talkies were used in the heist.
THE CENSUS AND MORTALITY STATISTICS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sustained Signaling through the B-Cell Receptor Induces Mcl-1 and Promotes Survival of Chronic Lymphocytic Leukemia B-Cells.
Authors: Dimitar G. Efremov, Aleksandar Petlickovski, Luca Laurenti, Xiaoping Li, Sara Marietti, Patrizia Chiusolo, Simona Sica, Giuseppe Leone
Journal: Blood (2004)
Authors' reply
Authors: A Ghirardello, A Doria, P F Gambari
Journal: Annals of the Rheumatic Diseases (1994)

<h3>Abstract</h3> Plants are colonised by millions of microorganisms representing thousands of species with varying effects on plant growth and health. The microbial communities found on plants are compositionally consistent and their overall positive effect on the plant is well known. However, the effects of individual microbiota members on plant hosts and <i>vice versa</i>, as well as the underlying mechanisms remain largely unknown. Here, we describe ‘Litterbox’, a highly controlled system to investigate plant-microbe interactions. Plants were grown gnotobiotically on zeolite-clay, an excellent soil replacement that retains enough moisture to avoid subsequent watering. Plants grown on zeolite phenotypically resemble plants grown under environmental conditions. Further, bacterial densities on leaves in the Litterbox system resembled those in temperate environments. A PDMS sheet was used to cover the zeolite, thereby significantly lowering the bacterial load in the zeolite and rhizosphere. This reduced the likelihood of potential systemic responses in leaves induced by microbial rhizosphere colonisation. We present results of example experiments studying the transcriptional responses of leaves to defined microbiota members and the spatial distribution of bacteria on leaves. We anticipate that this versatile and affordable plant growth system will promote microbiota research and help in elucidating plant-microbe interactions and their underlying mechanisms.
N-ethyl-tauroursodeoxycholic acid, a novel deconjugation-resistant bile salt analogue: Effects of acute feeding in the rat*1, *2
Authors: M ANGELICO
Journal: Hepatology (1995)

The purpose of this study was to investigate the physicochemical/biological properties and the effects of acute administration of N-ethyl-tauroursodeoxycholic acid in bile-fistula rats. In vitro determination of high-performance liquid chromatography mobility, octanol/water partitioning, cholesterol solubilizing capacity, and sensitivity to enzyme deconjugation by bacteria and cholylglycine-hydroxylase were performed. In vivo determination of the following was also performed: (1) maximum secretory rate (SRmax) and choleretic/secretory properties during intravenous (IV) administration; (2) site/extent of absorption, effects on bile flow, lipid secretion, and biotransformations after intraduodenal infusion. N-ethyl-tauroursodeoxycholate has a lipophilicity slightly higher than tauroursodeoxycholate, close to taurocholate, and similar cholesterol solubilizing capacity. Deconjugation of N-ethyl-tauroursodeoxycholate was 3.4 ±2.1% after 72 hours, that of tauroursodeoxycholate was 100% after 24 hours. During IV infusion of 300 nmol/min/ 100 g, biliary secretion of N-ethyl-tauroursodeoxycholic and tauroursodeoxycholic acids averaged 185 ±76 (standard deviation) nmol/min/100 g and 221 ± 77 nmol/min/ 100 g (not significant). Increasing infusion rates caused progressive enhancement of bile flow and bile salt secretion until the SRmax was reached (1,305 ± 240 nmol/min/ 100 g for N-ethyl-tauroursodeoxycholic acid and 3,240 nmol/min/100 g for tauroursodeoxycholate). The two bile salts were similarly choleretic. IV feeding of N-ethyltauroursodeoxycholic promoted a greater lipid secretion than tauroursodeoxycholate. After intraduodenal feeding of 800 μmol, 38.8 ± 14.0% and 43.4 ± 12.4% of the two bile salts were recovered in bile. No unconjugated bile salts nor unusual metabolites were detected. Excluding the distal 30 cm of the ileum, only 2.3 ± 0.7% of N-ethyl-tauroursodeoxycholic and 4.0 ± 2.3% of tauroursodeoxycholic acid was absorbed. N-ethyl-tauroursodeoxycholic is a new, hydrophilic, deconjugation-resistant, synthetic bile salt, which, in acute studies in the rat, behaves as the natural analogue with respect to intestinal and hepatobiliary properties.
Population-based monitoring of an urban HIV/AIDS epidemic. Magnitude and trends in the District of Columbia
Authors: P. S. Rosenberg
Journal: JAMA (1992)

<h3>Objective.</h3> —To assess the extent of the human immunodeficiency virus (HIV)/ acquired immunodeficiency syndrome (AIDS) epidemic in the District of Columbia and demonstrate an approach to monitoring HIV infection and projecting AIDS incidence at a community level. <h3>Design.</h3> —Backcalculation methods to reconstruct HIV incidence from AIDS incidence in subgroups. Results were compared with directly measured HIV seroprevalence in selected sentinel populations: childbearing women, civilian applicants for military service, and hospital patients admitted for conditions unrelated to HIV infection. <h3>Results.</h3> —Between the start of the epidemic in 1980 and January 1,1991, one in 57 District of Columbia men aged 20 to 64 years was diagnosed with AIDS. Unlike the plateau projected for the nation, AIDS incidence for the District of Columbia was projected to increase by 34% between 1990 and 1994. Models of HIV infection incidence suggested two broad epidemic waves of approximately equal size. The first occurred in men who have sex with men and peaked during the period from 1982 through 1983. The second began in the mid-1980s in injecting drug users and heterosexuals. We estimated that among District of Columbia residents aged 20 to 64 years, 0.3% of white women, 2.9% of white men, 1.6% of black women, and 4.9% of black men were living with HIV infection as of January 1,1991. These estimates are broadly consistent with survey data: among black childbearing women in their 20s, HIV prevalence doubled to 2% between the fall of 1989 and the spring of 1991; from military applicant data, we estimated that over 5% of black men born from 1951 through 1967 were HIV-positive; in the sentinel hospital, HIV prevalence rates among male patients aged 25 to 34 years were 11.3% in white men and 16.9% in black men. <h3>Conclusion.</h3> —Backcalculation and surveys yielded quantitatively consistent estimates of HIV prevalence. Many injecting drug users and heterosexuals in the District of Columbia were infected after January 1,1986. Similar monitoring of the epidemic in other localities is needed to focus efforts to reduce the incidence of HIV transmission. (<i>JAMA</i>. 1992;268:495-503)
Comparison of Cefuroxime With or Without Intranasal Fluticasone for the Treatment of Rhinosinusitis: The CAFFS Trial: A Randomized Controlled Trial—Correction
Authors: Hao Deng, Weidong Le, Joseph Jankovic
Journal: JAMA (2004)

peats expansion (57 CTG/CAG repeats) of JPH3 (HDL2) in the same patient, while a family member with full mutation of FMR1 and trinucleotide expansion of JPH3 showed no symptom of parkinsonism.Comment.Premutation of the FMR1 gene in men is associated with various movement disorders, including tremor, ataxia, and parkinsonism, that have clinical features overlapping with PD and essential tremor. 1,6We sought premutations in men with PD and in those with essential tremor to determine whether these 2 disorders are pathogenetically related to this genetic abnormality, but we found no FMR1 premutation in our population of patients with PD and essential tremor.This is consistent with other reports indicating lack of FMR1 premutation in patients with essential tremor, 7,8 atypical parkinsonism, and ataxias. 8Thus, premutation of FMR1 probably plays little or no role in the pathogenesis of idiopathic PD or essential tremor.Furthermore, it is unlikely that this genetic abnormality accounts for the male preponderance in patients with PD. 9