tbuckley/cabot-search huggingface dataset:
Breast-saving surgery, radiation for early cancer gaining advocates
Authors: W. A. Check
Journal: JAMA (1981)

A group of radiation therapists is becoming increasingly active in recommending to women with early breast cancer that they consider undergoing "definitive radiation therapy" in conjunction with breast-conserving surgery, or lumpectomy, instead of modified or radical mastectomy. The rationale, according to Luther W. Brady, MD, chairman of the Department of Radiation Therapy and Nuclear Medicine, Hahnemann Medical College, Philadelphia, is that "current evidence strongly suggests that radiation therapy in the primary local management of stage I and stage II breast cancer can achieve local-regional control rates that are comparable with those obtained by radical or modified radical mastectomy while leaving the patient with two intact and cosmetically acceptable breasts." The acceptance of such breast-saving treatment has become even more important with the increase in detection of breast cancer at an early stage, adds Brady. He cites National Cancer Institute data showing that the proportion of women whose disease was diagnosed
Septal ablation for hypertrophic obstructive cardiomyopathy: Normalization of an abnormal blood pressure response Lothar Faber, Bernd Werlemann, Peer Ziemssen, Hubert Seggewiss, Dieter Horstkotte. Heart Center North Rhine-Westphalia, Bad Oeynhausen, Germany, Leopoldina Hospital, Schweinfurt, Germany
Journal: Journal of the American College of Cardiology (2001)
Electroshock for atrial flutter and atrial fibrillation. Follow-up studies on 50 patients
Authors: J. B. Jensen
Journal: JAMA (1965)

The electrical conversion of atrial flutter and fibrillation to normal sinus rhythm is effective and safe. However, follow-up study of 50 patients showed that sinus rhythm persisted in only 42% of those patients whose arrhythmias were initially converted. The mean follow-up time was ten months. The immediate and long-term results were much better in patients with atrial flutter and in those with atrial fibrillation of less than two years' duration.
Neurological dysfunction of the bladder in workers exposed to dimethylaminopropionitrile
Authors: K. Kreiss
Journal: JAMA (1980)

Neurogenic bladder dysfunction, characterized by hesitancy, need to strain, decreased stream, and increased duration of urination, developed in 104 (63%) of 166 employees working in the manufacture of polyurethane foam. Highest rates of illness (69%) occurred in production workers, and no illness occurred in office or warehouse workers. Onset of the epidemic coincided with introduction of a catalyst, dimethylaminopropionitrile (DMAPN), and monthly case incidence rates increased as DMAPN use increased. Outbreak ceased abruptly when DMAPN use was stopped. Of eight patients who underwent neurourologic testing during recovery, seven lacked either detrusor reflex or normal sensation of bladder filling; seven had a subclinical sensory abnormality; three had prolonged sacral-evoked responses; and two of these three had limb motor neuropathies. Dimethylaminopropionitrile is unique among known neurotoxins in producing urinary symptoms more frequently than limb nerve symptoms. (<i>JAMA</i>243:741-745, 1980)
Boke of Chyldren
Authors: Not Available Not Available
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sexual dysfunction in Asian couples
Authors: D. Bhugra
Journal: BMJ (1986)

with those in the white population from the same catchment area.'Results in Asian women are much poorer than those in white women.Their complaints are also less accessible, more complex, and apparently more affected by transcultural factors than those of their husbands.Bangladeshi women here are socially, linguistically, and culturally more isolated.Also their complaints did not affect fertility as directly as their partners': they were often a manifestation of marital or family strife.Modified Masters and Johnson sex therapy can achieve a good outcome with male sexual problems in Bangladeshi patients when both partners attend.Motivation is likely to be highest when fertility is directly affected.
Staging Laparotomy
Authors: JACOB J. LOKICH
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 January 1972Staging LaparotomyJACOB J. LOKICH, M.D.JACOB J. LOKICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-1-143 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Johnson, in his report on "Staging Laparotomy in Hodgkin's Disease" (Ann Intern Med 75:459-462), has indicated that staging laparotomy should be performed in only two instances—in the presence of splenomegaly or in the presence of a positive lymphangiogram. He states that only in these two situations does the possibility of an alteration in therapy require confirmation. The implication is that in only these two situations does the likelihood of hepatic involvement become significant, which would in effect preclude radiotherapy and indicate the need for chemotherapy.This logic presumes a basic premise not clarified in his report.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Children's Cancer Research Foundation, Inc. Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHodgkin’s DiseaseRisk of Severe Infection in Patients with Hodgkin's Disease or Lymphoma After Diagnostic Laparotomy and SplenectomyRICHARD K. DESSER, M.D., JOHN E. ULTMANN, M.D., F.A.C.P. 1 January 1972Volume 76, Issue 1Page: 143-144KeywordsChemotherapyHodgkin lymphomaLaparotomySplenomegaly Issue Published: 1 January 1972 PDF DownloadLoading ...
Physical activity and body composition of adolescent boys
Authors: L. P. Novak
Journal: JAMA (1966)

Because physical activity has a profound effect on body composition and since this statement is popular knowledge, one might expect to find numerous scientific studies of the changes which occur in body composition under the influence of physical regimen. However, an intensive search through the literature has revealed few studies on this topic, and these few have had almost exclusively adult men as subjects. As background for this examination of adolescents and the effect of physical activity on body composition, the studies involving adult subjects will be summarized. Anthropometrical and skinfold appraisal of increased musculature or decreased subcutaneous fat tissues under the influence of various physical activities were reported by Tanner<sup>1</sup>and Thompson et al.<sup>2</sup>Densitometry was used by Behnke et al,<sup>3</sup>who were the first to point out, in their study of specific gravity of football players, that it may be erroneous to regard an individual
BLOOD TRANSFUSION
Authors: David Metheny
Journal: JAMA (1960)

<h3>To the Editor:—</h3> InThe Journal, July 2, is an editorial on the use of air pressure to speed up blood transfusion. The editorial seems not to take into account a common need for increasing pressure in the ordinary transfusion. Under some circumstances of blood loss, the general peripheral venous pressure goes up to such an extent that blood fails to run in. I have seen venous pressure so great that a bottle of blood held 5 ft. above the arm would not run into the anterior cubital vein. This is the equivalent of about 110 mm. Hg pressure. Under these circumstances, I suggest that, instead of using air or other means of pressure to force blood into an already constricted venous system that is not transporting it to the heart, a transfusion be given into one of the larger arteries, such as the femoral.
Abstract 2367: Enhancing the efficacy of liver cancer immunotherapy by specific inhibition of histone deacetylase 8
Authors: Wei-Qin Yang, Jingying Zhou, Yu Feng, Ka Wing Cheung, Alfred Sze-Lok Cheng
Journal: Cancer Research (2019)

Abstract The heterogeneous responses to immune-checkpoint blockade (ICB) therapy e.g. anti-programmed death-ligand 1 (PD-L1) antibody are attributable to the complex interplay between a range of cancer-cell-autonomous cues and the immunosuppressive tumor microenvironment. Two recent phase I/II trials of checkpoint inhibitors in patients with advanced hepatocellular carcinoma (HCC) have produced promising results, yet the objective response rates were relatively low (17-20%) as compared to other solid tumors such as melanoma and lung cancer (~40-60%). Accumulating evidence is underscoring the fundamental importance of epigenetic regulation in tumor immune evasion. We have previously elucidated a critical role of histone deacetylase 8 (HDAC8) in hepatic carcinogenesis (Cancer Research 2015;75:4803-16). Here, we aim to investigate the therapeutic potential of a HDAC8-specific inhibitor PCI-34051 in preclinical hepatocellular carcinoma (HCC) models. PCI-34051 significantly reduced HCC tumorigenicity in immunocompetent but not immunodeficient mice. Immune profiling revealed specific reduction in tumor-infiltrating regulatory T cells, which was associated with significant increase in CD8+ T cells. Notably, combined PCI-34051 and anti-PD-L1 treatment resulted in complete tumor eradication in all of the co-treated mice. Moreover, the combination therapy promoted long-term survival, which was associated with elevated CD8+ T effector and central memory cells. Our data suggest that selective chromatin modifications by HDAC8 alter the tumor immune surveillance program and demonstrate the potential of rational combinatorial epigenetic immunotherapy to fully unleash T-cell responses, leading to long-term remission of HCC. Acknowledgement: This work is supported by the RGC CRF (C4017-14G) and the Focused Innovations Scheme-Scheme B from the Chinese University of Hong Kong (1907309). Citation Format: Wei-Qin Yang, Jingying Zhou, Yu Feng, Ka Wing Cheung, Alfred Sze-Lok Cheng. Enhancing the efficacy of liver cancer immunotherapy by specific inhibition of histone deacetylase 8 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2367.
Endoscopic Ultrasonography
Authors: M Polkowski
Journal: Endoscopy (2006)

A computer search on the PubMed database, followed by manual verification of the records retrieved, identified a total of 235 papers on the topic of endoscopic ultrasonography (EUS) published in English from July 2004 to June 2005 (electronic publications ahead of print are not included). Many papers were also published on transbronchial, laparoscopic, mediastinoscopic, and transrectal (rigid probe) ultrasound, but these are not covered in this review.
Incorrect Wording in Results
Journal: JAMA Network Open (2019)

In the Original Investigation titled "Trends in Health Equity in the United States by Race/Ethnicity, Sex, and Income, 1993-2017" 1 published June 28, 2019, the changes in mean (SD) scores for the health equity metric between 1993 and 2017 for both Figure 1 and Figure 2 were incorrectly described as "increasing" on initial publication.In the third paragraph of Results, the sixth sentence should have read, "The Health Equity Metric had a mean (SD) of 0.32 (0.13) units in 1993, decreasing to 0.13 (0.15) units in 2017," and the 10th sentence should have read, "The health equity metric had a mean (SD) of 0.932 (0.019) units in 1993, decreasing to 0.926 (0.016) units in 2017."This article has been corrected.
Medical News &amp;amp; Perspectives
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of the Eye
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Domestic Abstracts
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevention and Control of Tuberculosis in Correctional Institutions: Recommendations, Advisory Committee for Elimination of Tuberculosis
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: R. J Huxtable, W M. Lafranconi
Journal: Thorax (1984)

Lung angiotensin converting enzyme activity in monocrotaline pulmonary hypertension SIR,-We have shown that lung tissue angiotensin convert- ing enzyme (ACE) activity was reduced in rats with pul- monary hypertension induced by a single injection of monocrotaline (Thorax March 1982, p 198).Lafranconi and Huxtable, however (April 1983, p 307), have sug- gested that this decrease in specific activity of ACE was due to an increase in total lung protein and not to an actual reduction in the total ACE activity in the lung.We have therefore recalculated our data in terms of total ACE activ- ity per lung (nmol/min/lung).The mean (SD) value for the control group (n = 10) was 1379-9 (492-9), and for the group treated with monocrotaline (n = 7) 657*4 (225.2).Thus there was a significant decrease in total lung ACE activity in the rats treated with monocrotaline (t = 3.597, p < 0-005).In a recent experiment' we measured angiotensin II immunoreactive material in right ventricular and aortic blood derived from control rats (n = 7) and rats given a single injection of monocrotaline (n = 5).In the
Morale: The Mental Hygiene of Unemployment for Unemployment Relief Workers, Social Workers, Public Health and Visiting Nurses, Community Chest Executives, Public Officials, Clergymen and Members of Boards of Philanthropic Organizations.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAT0565 Reliability of The Quantitative Assessment of Peripheral Blood Perfusion by Laser Speckle Contrast Analysis in A Systemic Sclerosis Cohort: Table 1.
Authors: V. Lambrecht, M. Cutolo, F. De Keyser, S. Decuman, B. Ruaro, A. Sulli, E. Deschepper, V. Smith
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> In systemic sclerosis (SSc) there is increasing interest to evaluate blood perfusion in a dynamic way, to evaluate evolution of disease and response to therapy. Laser speckle contrast analysis (LASCA) is an emerging technique that measures peripheral blood perfusion (PBP) in real time over a large area and is convenient in use (1,2). In order to be used as an outcome measure, first reliability of LASCA needs to be attested. <h3>Objectives</h3> To investigate the reliability of the quantitative assessment of PBP by LASCA between two raters in a SSc cohort. <h3>Methods</h3> Two independent raters evaluated PBP in 40 consecutive patients with SSc (according to the 2013 ACR/EULAR classification criteria) using LASCA. After acclimatization for 20 minutes in a temperature controlled room, PBP was measured at the level of the fingertips, dorsal and volar bilaterally, for 30 sec each. Measurements were performed under standardized environmental, patient and instrumental conditions. PBP values were reported as perfusion units (PU) by creating regions of interest with fixed 1 cm diameter at central area of the fingertips. Mean PU per finger, left and right, dorsal and volar, per rater was calculated. Inter rater reliability was assessed by calculation of intraclass correlation coefficients (ICC). Patients with flexion contractures (n=6) were excluded because they could not meet the standardization requirements. <h3>Results</h3> ICC (95% confidence interval) values for PBP measurements varied from 0.82 (0.67 to 0.91) to 0.91 (0.83 to 0.96) for the dorsal fingertips, and from 0.74 (0.55 to 0.86) to 0.86 (0.74 to 0.93) for the volar fingertips (Table 1). <h3>Conclusions</h3> This is the first study to demonstrate reliability of the quantitative assessment of peripheral blood flow by LASCA in a SSc cohort between two raters, performed under standardized patient, instrumental and environmental conditions. With this study, we took the first step in the validation of LASCA, though further studies are needed to confirm these results. <h3>References</h3> Cutolo M, et al. Assessing microvascular changes in systemic sclerosis diagnosis and management. Nat Rev Rheumatol 2010;6:578–87. Ruaro B, et al. Laser speckle contrast analysis: a new method to evaluate peripheral blood perfusion in systemic sclerosis patients. Ann Rheum Dis 2014;73(6):1181–5. <h3>Disclosure of Interest</h3> None declared