tbuckley/cabot-search huggingface dataset:
THE ENGLISH LANGUAGE AND MEDICINE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
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Authors: N P M Nolan, D S O'Briain
Journal: Gut (1988)

Nevertheless, further bacteriological characterisation, including antimicrobial resistance patterns and fermentative reactions in sugars, permitted a clear distinction between six different Clostridium difficile species.We would recommend, therefore, that case clustering of PMC, suggestive of nosocomial cross infection, is evaluated prospectively using bacteriological typing methods.
Disregard
Authors: LeNeva Spires
Journal: Annals of Internal Medicine (2015)

Ad Libitum19 May 2015DisregardLeNeva Spires, BALeNeva Spires, BAFrom Oregon Health & Science University, Portland, Oregon.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-0194 Audio Reading - “Disregard” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Disregard," by L. Spires. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Outside the children's hospitalyou will find them.Their burning prayers rise up to the windowsand beyond. Inside the children in red wagons have no hair wear tubes and cords with cartoon pajamas. Once I saw a gurney there with only a small still covered lump. The parents … The parents wear expert smiles like armor but also sometimes tears.Outsidedespite the signsoutside you will find themsmoking.LeNeva Spires, BAOregon Health & Science UniversityPortland, Oregon Author, Article, and Disclosure InformationAffiliations: From Oregon Health & Science University, Portland, Oregon.Current Author Address: LeNeva Spires, BA; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Disregard” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Disregard," by L. Spires. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 19 May 2015Volume 162, Issue 10Page: 740KeywordsChildren ePublished: 19 May 2015 Issue Published: 19 May 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
From the Centers for Disease Control. Interpretation and use of the western blot assay for serodiagnosis of human immunodeficiency virus type 1 infections
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human intersex
Authors: George W. Corner
Journal: JAMA (1963)

Human intersex has always fascinated mankind. References to hermaphroditism are part of the folklore of every culture. It is only in the past 10 or 15 years, however, that such strange anomalies of sexual development have excited much more than curiosity or ribaldry. The discovery, by Barr, of the sex chromatin body, the working out of accurate techniques for chromosome counting by Tjio, and the studies of chromosome morphology by Ford have not only revolutionized genetics but have made it possible to replace folklore, ribaldry, and curiosity with science. This little book reviews our new knowledge of human intersex up to 1961. While it is already out of date, it performs an invaluable service in collecting information from various biological disciplines in one conveniently small volume, complete with 43 pages of bibliography. Thus, there is no doubt that it will be an invaluable reference work for biologists, students of the
Idiopathic Thrombocytopenic Purpura
Authors: Mario Baldini
Journal: New England Journal of Medicine (1966)

Symptomatic Immunologic Thrombocytopenic PurpuraAssociation with Virus DisordersProbably only chronic thrombocytopenic purpura is truly idiopathic. The acute form is often preceded by a "viral" infection, particularly the exanthematous infections of children, and may therefore have a clear etiology.Viruses have been associated with thrombocytopenia in various ways. Recent studies, including those of me and my co-workers,10, 78 have shown that human blood platelets contain large amounts of sialic acid (assumed to be the virus receptor) and that myxoviruses are adsorbed to and eluted from blood platelets. In this process of adsorption and elution blood platelets undergo severe morphologic changes and . . .
Impact of cuts in acute beds on services for patients.
Authors: R Beech, S Challah
Journal: BMJ (1987)

The current redistribution of resources in the National Health Service will require a reduction in the number of acute beds in many district health authorities.The effect of such a reduction on services for patients was examined.Two hundred and two general medical admissions and 201 general surgical admissions to hospitals in West Lambeth District Health Authority were reviewed retrospectively.The elements considered were the severity of the patient's illness at admission, the scope for reducing the length of stay, the potential for other forms of care, and what types of patients would be denied access at different levels of reductions in the number of beds.Given the assumptions a considerable potential for maintain- ing levels of service with fewer beds was identified.The finding was, however, that even if all of this potential was realised the cuts in the number of beds that are planned by districts that are losing resources would force real reductions in patient services.This suggests a "trade off."To increase services in districts that are gaining resources, real unmet need may have to be created in districts that are losing resources.
Phase III study of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (A+AVD) versus doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) as front-line treatment for advanced classical Hodgkin lymphoma (HL).
Authors: Anas Younes, John Radford, Stephen Maxted Ansell, Andrea Gallamini, Won Seog Kim, Tatyana A. Feldman, Mehdi Hamadani, Jeanenne Chung, Jingyuan Wang, Dirk Huebner, Joseph M. Connors
Journal: Journal of Clinical Oncology (2013)

TPS8612 Background: Brentuximab vedotin, a CD30-targeted antibody-drug conjugate, has conditional approval in Europe for relapsed/refractory (RR) CD30-positive HL following autologous stem cell transplant (ASCT) or following ≥2 prior therapies when ASCT or multi-agent chemotherapy is not a treatment option. ABVD, a common front-line regimen for advanced HL, achieves complete response (CR) rates of 70–80%. However, 10–20% of patients (pts) are refractory to front-line treatment and up to 35% relapse after front-line multi-modality therapy. In pts with relapsed HL post-ASCT, single-agent brentuximab vedotin yields an objective response rate of 75% (CR, 33%; Chen ASH 2012). In a phase 1 study in treatment-naïve HL pts, A+AVD was associated with manageable toxicity and a CR rate of 96%; brentuximab vedotin + ABVD was contraindicated due to pulmonary toxicity (Ansell ASH 2012). We hypothesized that substituting bleomycin with brentuximab vedotin would eliminate bleomycin-associated pulmonary toxicity and improve progression-free survival (PFS) compared to a standard ABVD regimen. Methods: This ongoing, open-label, randomized, multicenter study (NCT01712490) will compare A+AVD vs ABVD in 1040 pts with stage III/IV classical HL. Primary endpoint: modified (m) PFS (death, progression, and receipt of chemotherapy or radiotherapy by pts not in CR after completing A+AVD or ABVD will count as progression event). Key secondary endpoint: overall survival. Key inclusion criteria: histologically-confirmed previously untreated stage III/IV classical HL. Pts will be stratified by region and International Prognostic Score, and will be randomized 1:1 to receive A+AVD (brentuximab vedotin 1.2 mg/kg with each dose of AVD) or ABVD administered intravenously on Days 1 and 15 of 28-day cycles, for up to 6 cycles. Disease status and survival will be evaluated regularly until study closure. Safety assessments: incidence and severity of adverse events, changes to physical and laboratory tests. Clinical trial information: NCT01712490.
Postpartum haemorrhage after induced and spontaneous labour.
Authors: Jerome Appelbaum
Journal: BMJ (1978)

an objective remission in one patient who underwent hormonal ablation and was shown to be ER-negative, PgR-positive.I hope that the above-cited references will correct the impression that only ER-positive tumours contain PgR.Although the number of cases of PgR-positive, ER-negative tumours is small, they do exist.The importance of recognising this group of mammary carcinomas is that it may provide new insights into the interrelationship that exists between various hormones, their receptors, and tumour regression.
Thoracic origin of a single renal artery
Authors: C. J. Tegtmeyer
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The renal arteries typically arise between the midportion of the first lumbar vertebral body and the upper third of the second.<sup>1-4</sup>Variations of approximately one vertebral body in either direction are well known. To the best of our knowledge, only one case of a single renal artery is reported arising above the level of the 12th thoracic vertebra,<sup>5</sup>accompanied by a normal contralateral renal artery. In the present case, single right renal artery arose at the level of the 11th thoracic vertebra, with agenesis of the left kidney, the only example reported so far as we know. <h3>Report of a Case.—</h3> A 40-year-old Negro woman entered the hospital for investigation of discomfort of several weeks' duration in the left lower quaddrant of the abdomen. Intravenous urography demonstrated a normal right kidney and collecting system; however, the left kidney was not visualized. Cystoscopic examination and retrograde
Dermatology
Authors: Jeffrey S. Dover
Journal: JAMA (1993)

Erythromycin resistance to group A streptococci is a serious clinical problem because there are few alternative oral therapies for the treatment of streptococcal infections in patients who are allergic to penicillins and cephalosporins. In Finland between 1979 and 1989, as the use of erythromycin was nearly tripling, an unusually high frequency of such resistance was noted in one geographic region. A national study of 272 isolates of group A streptococci obtained from blood cultures, 3087 consecutive isolates from throat swabs, and 1349 isolates from skin swabs revealed that the frequency of resistance to erythromycin had increased in blood cultures from 4% in 1988 to 24% in 1990, in throat swabs from 7% in 1988 to 20% in 1990, and in skin swabs from 11% in 1988 to 31% in 1990. This rapid and substantial increase in resistance to erythromycin in group A streptococci and the failure of erythromycin treatment to
Improved Methods of Blood Transfusion for Patients With Sickle Cell Anemia
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fibrinogen Bellingham: A γ‐chain R275C substitution and a β‐promoter polymorphism in a thrombotic member of an asymptomatic family
Authors: M.L. Linenberger, J. Kindelan, R.L. Bennett, A.P. Reiner, H.C.F. Côté
Journal: American Journal of Hematology (2000)

Congenital dysfibrinogenemia is a rare cause of unexplained thrombosis. However, most individuals with dysfibrinogenemia are asymptomatic, suggesting that co-morbid factors contribute to thrombo-embolic events. The potential roles of additional genetic or acquired prothrombotic risk factors are poorly understood because detailed family studies are lacking. Herein, we describe a family whose propositus was a young Caucasian man with recurrent venous thrombo-emboli and dysfibrinogenemia due to heterozygosity for an Arg→Cys substitution at residue 275 in the γ-chain. The only additional thrombophilic abnormality found in the proband was heterozygosity for a G/A transition at position −455 in the fibrinogen β-chain promoter; a genotype associated with high acute phase levels of fibrinogen. The proband's father, who died of a cerebral artery thrombosis, carried the γR275C substitution but not the β-promoter −455 variant. Among 14 living relatives, eight were heterozygous for one or the other mutation and only one, a 21-year-old niece, was dually affected. None had suffered bleeding or thrombosis. In vitro studies of the proband's purified fibrinogen revealed markedly abnormal thrombin-catalyzed polymerization and delayed fibrin clot lysis by tPA-activated plasmin. We hypothesize that the γR275C substitution predisposes to thrombosis by generating clots that are relatively resistant to fibrinolysis. The clinical risk is low, however, in the absence of an additional thrombophilic mutation. The β-promoter variant could, theoretically, contribute to this risk by augmenting expression of the dysfibrinogen under conditions of stress. Like the common hereditary thrombophilias, heterozygous familial dysfibrinogenemia induces thrombosis in the setting of multiple prothrombotic influences. Am. J. Hematol. 64:242–250, 2000. © 2000 Wiley-Liss, Inc.
The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. I. Surface immunoglobulin isotypes on primed B cells in the spleen.
Authors: I Zan-Bar, S Strober, E S Vitetta
Journal: The Journal of Experimental Medicine (1977)

We investigated the ability of IgM-, IgD-, and IgG-bearing cells from the spleens of (BALB/c x C57BL/Ka)F1 mice primed to dinitrophenyl-bovine serum albumin (DNP-BSA) to restore the adoptive secondary anti-BSA and anti-DNP antibody responses. A rabbit anti-mouse IgD antiserum was prepared and the specificity documented by radioimmunoprecipitation, and cell surface staining. Purified populations of IgM-, IgD-, and IgG-bearing cells were prepared by immunofluorescent staining with isotype-specific reagents, and sorting on the fluorescence activated cell sorter. Bright or dull cells were transferred to irradiated syngeneic recipients which were challenged with DNP-BSA in saline. Unfractionated spleen cells restored an adoptive secondary serum antibody response which was all IgG (2-mercaptoethanol resistant). Purified IgM- or IgD-bearing cells restored both the secondary IgM and IgG antibody response. IgG-bearing cells restored only the IgG response. In addition, the IgG-bearing cells appear to suppress the adoptive secondary IgM response, since depletion of IgG-bearing cells from transferred spleen cells results in a marked increase in the adoptive IgM response.
Editorial: Intermediate coronary syndrome.
Journal: BMJ (1973)

Intermediate Coronary SyndromeCardiologists have a reputation for coining new terms in which to obscure previously well recognized entities.When angina pectoris recurs at rest and infarction seems imminent, or angina is of recent onset or has newly become severe or prolonged, the clinical syndromes have been given many names.These included acute coronary insufficiency,'-5 the intermediate coronary syndrome,67 acute myocardial ischaemia,89 pre-infarction angina,10-15 impending myo- cardial infarction,'6 status anginosus,17 unstable angina,'8-20 and accelerated angina.2'Nearly 200/, of admissions to coronary care units are sub- sequently placed in this intermediate category between stable angina and acute infarction.5 Reports vary on the risk of the patient's progressing to infarction from this unstable state.Earlier estimates were high-22% within two months,2
A Nested Case-Control Study of Kidney Cancer among Refinery/Petrochemical Workers
Authors: John F. Gamble, Eileen D. Pearlman, Mark J. Nicolich
Journal: Environmental Health Perspectives (1996)

A nested case-control study was designed to evaluate whether a nearly twofold excess of kidney cancer among workers at a refinery/petrochemical plant was associated with cumulative exposure to C2-C5 saturated, C2-C5 unsaturated, C6-C10 aliphatic saturated, C6-C10 aliphatic unsaturated, and C6-C10 aromatic process streams. Nonoccupational risk factors were body mass index (BMI), blood pressure (both measured at about age 28), and smoking. There was no significant association with cumulative exposure or tenure as estimated by conditional logistic regression and adjusted for nonoccupational risk factors. Categorical analysis showed increased odds ratios only in the second (low) and fourth (high) quartiles compared to the first quartile reference group of lowest exposed workers, and a three-quarter-fold increased odds ratio for > 32 years' tenure compared to the < 25-year reference group. The number of cases was small with wide confidence intervals around estimate of risk, so the possibility of an exposure-response trend cannot be ruled out. Multivariate analysis identified overweight (high BMI; p < 0.01) as the most important risk factor in this data set, followed by tenure and increased blood pressure. There was a weak association with current smoking, but not with pack-years smoked. The risk of kidney cancer for a nonsmoker with normal blood pressure but 25% overweight was increased about 2.6-fold (95% CI = 1.2-5.4). The risk of kidney cancer for a nonsmoker of normal weight with high blood pressure (e.g., 150/110), was increased about 4.5 (95% CI, 0.8-26).
Medical Education Programs Sponsored by Government Agencies
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stress fractures of the os calcis
Authors: R. E. Darby
Journal: JAMA (1967)

THE INCIDENCE of stress fractures of the os calcis has been previously reported as low. Records of the German Army Hospitals for the year 1935 through 1936 indicated that of 590 stress fractures only four were observed in the os calcis.<sup>1</sup>Carlson and Wertz<sup>2</sup>reported a series of 70 stress fractures of which 66 occurred in the metatarsal, three were noted in the femur, and one was observed in the calcaneus. Hullinger<sup>3</sup>presented 71 calcaneal stress fractures demonstrated in 53 patients; bilateral involvement was indicated in 18 patients (34%). Bilateral involvement was noted in 11 patients (35% ) reported by Winfield and Dennis<sup>4</sup>who observed 42 calcaneal stress fractures in 31 patients. Winfield and Dennis<sup>4</sup>and Hullinger<sup>3</sup>did not report the incidence of calcaneal stress fractures with respect to the total number of stress fractures involving all sites. <h3>Clinical Findings</h3> The patients in this series