tbuckley/cabot-search huggingface dataset:
Amer Journal of Medical Electronics, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aphorismes de médecine clinique.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Orthopedics, Occupational Disorders
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Springtime Peaks of Trace Metals in Antarctic Snow
Authors: Masaya Ikegawa, Mieko Kimura, Kazuto Honda, Kazuo Makita, Yoshiyuki Fujii, Yoshinori Itokawa
Journal: Environmental Health Perspectives (1997)

Drifting snow samples were collected at Asuka Station (71 degrees 32'S, 24 degrees 08'E, 930 m above sea level) over a period from July to December 1991; 36 elements (including Na, Mg, K, Ca, Fe, Al, Li, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, Se, Rb, Sr, Cd, Pb, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and Th) in snow were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) by direct sample introduction. Concentrations of Cl-, NO3-, and SO(4)2- in the snow were also determined by ion chromatography. In late September to early October, there was a pronounced peak concentration of most of the elements together with non-sea salt sulfate. Enrichment factor analyses suggest that Na, Mg, Ca, K, and Sr are of marine origin and Al, Fe, Mn, Rb, Cr, Ni, Ga, V, and all the rare earth elements are of crustal origins. Volcanic eruption of Mt. Pinatubo (June 1991) and Mt. Hudson (August 1991) could be the reason for the precipitation of Pb, Cd, Cu, Zn, and Se together with non-sea salt sulfates in the austral spring at Asuka Station.
Author’s correction for Euro Surveill. 2020;25(10)
Journal: Eurosurveillance (2020)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Closure This is a corrected article applying to the following content: Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020
Prevalence of Self-Reported Arthritis or Chronic Joint Symptoms Among Adults—United States, 2001
Journal: JAMA (2002)

Arthritis and other rheumatic conditions comprise the leading cause of disability among adults in the United States, and the cost of this public health burden is expected to increase as the U.S. population ages. State-specific estimates of the prevalence of arthritis and chronic joint symptoms (CJS) are important for planning health services and programs to prevent arthritis-related disability and for tracking progress toward meeting state and national health objectives for 2010. In 2001, questions about arthritis and CJS were asked of adult respondents in every state through the Behavioral Risk Factor Surveillance System (BRFSS). This report summarizes the results of that survey, which indicate that the estimated U.S. prevalence of arthritis/CJS was 33.0% among adults. Increased intervention efforts, including early diagnosis and appropriate clinical and self-management (e.g., physical activity, education, and maintaining appropriate weight), are needed to reduce the impact of arthritis and CJS.
TRTH-31. EFFECTS OF TORC1/2 INHIBITOR MLN0128 ALONE AND IN COMBINATION WITH MEK INHIBITION IN BRAF MUTATED GLIOMA CELLS
Authors: Sabine Mueller, Rogier Dirk, Xiaodong Yang, Steve DuBois, Angela Waanders, Adam Resnick, William Weiss, Daphne Haas-Kogan
Journal: Neuro-Oncology (2017)

INTRODUCTION: MLN0128, a second-generation ATP-competitive pan-mTOR kinase inhibitor, acts on both mTORC1 and mTORC2. We investigated the effects of MLN0128 monotherapy and in combination with MEK and BRAFV600E inhibition in models of pediatric low-grade glioma (PLGG). METHODS: We used human glioma cell lines expressing BRAFV600E (AM38), wild-type BRAF (LN229, TN98, SF188) and isogenic systems of KIAA1549:BRAF-expressing NIH3T3 cells. Signaling inhibitors included MLN0128, everolimus, BRAFV600E specific inhibitor PLX4720, and MEK specific inhibitors AZD6244 and GSK1120212. Cell proliferation was determined using an ATP-based assay. Biochemical effects were assessed using western blot analysis. The DBTRG (BRAFV600E) xenograft mouse model was used to assess in vivo efficacy. RESULTS: MLN0128 monotherapy demonstrates more potent anti-proliferative effects compared to everolimus in all tested PLGG lines independent of BRAF status. As expected, treatment with MLN0128 leads to down-regulation of p-AKT, p-S6 and p-4EBP1, whereas treatment with everolimus only reduces expression of p-S6. MEK inhibition with AZD6244 effectively decreases p-ERK expression in all lines; however, the addition of MLN0128 to AZD6244 causes a rebound in p-ERK expression in BRAFWT gliomas but not in gliomas expression BRAFV600E or KIAA1549:BRAF alterations. In cells carrying either the BRAFV600E or KIAA1549:BRAF alteration, combined treatment with MLN0128 and GSK1120212 or AZD6244 leads to synergistic anti-proliferative effects but such synergy is not evident in BRAFWT gliomas. In vivo studies show superior efficacy of combinations of PLX4720 and MLN0128 compared to monotherapies (p<0.02) or combination of PLX4720 + everolimus (p=0.03). CONCLUSION: MLN0128 displays synergistic anti-neoplastic effects with MEK inhibition in gliomas bearing BRAFV600E or KIAA1549:BRAF. In BRAF wild-type cells such synergy is not present, potentially due to rebound in p-ERK when MLN0128 is combined with AZD6244. Combination therapy with MLN0128 + PLX4720 prolongs survival in a BRAFV600E mutant glioma model and is superior to monotherapy or everolimus + PLX4720 combination.
Autoimmune Diseases
Authors: Anne Davidson, Betty Diamond
Journal: New England Journal of Medicine (2001)

Autoimmune diseases, with the exception of rheumatoid arthritis and autoimmune thyroiditis, are individually rare, but together they affect approximately 5 percent of the population in Western countries.1,2 They are a fascinating but poorly understood group of diseases. In this review, we define an autoimmune disease as a clinical syndrome caused by the activation of T cells or B cells, or both, in the absence of an ongoing infection or other discernible cause. We will discuss a classification of autoimmune disease that distinguishes diseases caused by generalized defects in lymphocyte selection or homeostasis from those caused by aberrant responses to . . .
Complete responders to chemotherapy in metastatic breast cancer. Characterization and analysis
Authors: D. A. Decker
Journal: JAMA (1979)

Four hundred thirty-eight patients with metastatic breast cancer treated with nine prospective randomized trials were reviewed to analyze, characterize, and compare those with complete regression (CR) (N=49 [11%]) with those with noncomplete regression (non-CR) (N=389 [89%]). Site of dominant disease was identical in the CR and non-CR patients. However, CR was statistically more likely when the disease-free interval and the postmenopausal status was five years or less. Survival and time to progression were statistically similar for osseous, visceral, and soft-tissue-dominant disease. Relapses generally occurred at sites of prior dominant disease, except that relapses occurred in the CNS in 14%. Six CR patients received prolonged chemotherapy and were believed to be "cured" when treatment was discontinued; however, all except one have had relapses. (<i>JAMA</i>242:2075-2079, 1979)
THE TREATMENT OF LUPUS VULGARIS WITH SOLUTION OF MERCURIC NITRATE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
House
Authors: James Owen Drife
Journal: BMJ (2005)

Hallmark Channel, Sundays at 9 pm and Mondays at 1 am http://www.hallmarkchannel.co.uk/ Currently showing in the US on Fox www.fox.com/house/ Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> A t only 45, Hugh Laurie is well on the way to becoming a national treasure. His credentials are impeccable. Old Etonian, member of a losing Oxford and Cambridge Boat Race crew, hilarious portrayer of upper class twits in Blackadder . And in the 1990s, playing Bertie Wooster to Stephen Fry's Jeeves, he was lovable Englishness personified. So when the BMJ sent preview tapes of his new show on a satellite channel, I was looking forward to a cheerful evening. OK, it was a US series, and OK, he was playing a doctor, but the theme would surely be Gussie Fink-Nottle meets Malibu Beach, and I was going to enjoy it. Never very adept with the video player, I watched the first few minutes with no sound. First surprise. This was Laurie unshaven, in 101 Dalmatians mode. Remember how scary he was as Cruella de Ville's henchman, intent on drowning those puppies? Then I … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Final Results Of a Phase II Study Of Lenalidomide In Combination With Rituximab For The Treatment Of Indolent Non Follicular Non Hodgkin Lymphoma
Authors: Stefano Sacchi, Samantha Pozzi, Marina Cesaretti, Luigi Marcheselli, Gabriele Buda, Antonio Lazzaro, Luca Baldini, Francesco Di Raimondo, Pellegrino Musto, Alfonso Zaccaria, Giorgina Specchia, Umberto Vitolo, Massimo Magagnoli, Franco Silvestris, Pier Paolo Fattori, Patrizia Tosi, Eliana Valentina Liardo, Alessia Bari, Angelo Michele Carella
Journal: Blood (2013)
Meconium Peritonitis
Authors: George T. Kammerer
Journal: JAMA (1965)

MECONIUM PERITONITIS is a sterile chemical peritonitis that occurs in utero or during birth as the result of a communication between the intestinal tract and the peritoneal cavity. If peritoneal contamination continues after the first 24 hours of life, secondary bacterial peritonitis will ensue. The condition is rare; Bendel and Michel report three cases in 108,744 consecutive live births at Charity Hospital in New Orleans.<sup>1</sup> Meconium peritonitis usually presents itself as intestinal obstruction on the first to seventh day of life. There have been cases reported of a rupture of the gastrointestinal tract without associated anomalies; more frequently, however, there is a mechanical obstruction distal to the site of perforation. The most common causes of obstruction are atresia, stenosis, inspissated meconium, or volvulus. The x-ray picture of the abdomen is classical, with findings of intestinal obstruction and fine granular intra-abdominal calcifications.<sup>4</sup>These calcifications are calcified salt deposits of
ATYPICAL MUMPS
Authors: William L. Gould
Journal: JAMA (1924)

Recently, a woman, aged 20, married, came to me complaining of pains and swelling in the left side of the body. Three weeks before, she became ill. On arising one morning, she was seized with headaches, dizziness, nausea and pains in the back, legs and abdomen. Within twenty-four hours, the left side of the body became painful, tender and swollen. On examination three weeks later, at my office, there was found a typical acute inflammation of the left parotid gland. The left breast was painful, tender and somewhat indurated. The left upper and lower extremities were generally, but moderately, tender and swollen. The swelling was more acute for the first week. The affected parts had constant, cramplike pains, and were not discolored. On the nineteenth day after the onset, the tongue became swollen, this condition lasting throughout one night. The pains in the epigastrium, which came especially after meals, the
Bittersweet
Authors: Marc J. Straus
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1349: Overexpression And Dominant-negative Suppression Of Inwardly Rectifying Potassium Channel Protein (Kir2.1) Alters Electrophysiology And Spiral Wave Dynamics Of An <i>In Vitro</i> Model Of Cardiac Myocytes
Authors: Rajesh B Sekar, Eddy Kizana, Hee C Cho, Rachel R Smith, Brett P Eaton, Eduardo Marbán, Leslie Tung
Journal: Circulation (2007)

Introduction : An important role for the inwardly rectifying potassium current (I K1 ) has been postulated in controlling the stability and frequency of rotors responsible for ventricular tachycardia and fibrillation. We investigated the effects of Kir2.1 overexpression and Kir2.1AAA dominant-negative mutant suppression on the electrophysiology and inducibility, stability and frequency of spiral waves in an in vitro cardiac tissue model. Methods/Results : Neonatal rat ventricular myocytes (NRVMs) were transduced by lentiviral vectors encoding Kir2.1 or Kir2.1AAA. Immunostaining revealed Kir2.1 or mutant Kir2.1 protein overexpression and whole cell-clamp confirmed the predicted effects on I K1 , resting potential, and action potential duration (APD 80 ). Optical mapping was performed on confluent NRVM monolayers containing a 5 mm diameter central island of gene-modified NRVMs created by a stenciling technique. APs propagated with increased CV (25.1±2.7 cm/sec, n=7) and shortened APD 80 (73±11 msec, n=7) in islands of Kir2.1 overexpression, or decreased CV (13.1±1.1 cm/sec, n=7) and prolonged APD 80 (263±14 msec, n=7) in islands of Kir2.1AAA suppression, compared with normal CV and APD 80 of 19.2±0.4 cm/sec and 169±14 msec (n=7) in non-transduced islands. Reentry was initiated by rapid pacing. With Kir2.1 overexpression, reentrant waves anchored to the island and remained stable (89±15 minutes, n=3) with a frequency of 8±2 Hz. Superfusion with 0.5 mM BaCl 2 to block I K1 slowed reentry to 1 Hz and terminated it shortly after initiation. NRVM monolayers with islands of Kir2.1AAA suppression (n=3) displayed rapid spontaneous activity. Rapid pacing of these monolayers initiated an unstable figure-of-eight reentry (n=3) that degraded into single and multi-armed spiral waves, anchored to varying parts of the island with a maximum frequency of 2±1 Hz. Importantly, no reentry could be initiated in monolayers with non-transduced islands (n=3). Conclusion : Functional reentrant waves induced by rapid pacing are anchored to islands of localized Kir2.1 overexpression whereas they drop in frequency and meander in islands of dominant-negative suppression of Kir2.1, confirming the importance of I K1 for the stability of these waves in cardiac tissue.
Community Intervention Trial for Smoking Cessation (COMMIT): Summary of Design and Intervention
Journal: JNCI Journal of the National Cancer Institute (1991)

Community Intervention Trial for Smoking Cessation (COMMIT): Summary of Design and Intervention Get access COMMIT Research Group COMMIT Research Group Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 22, 20 November 1991, Pages 1620–1628, https://doi.org/10.1093/jnci/83.22.1620 Published: 20 November 1991 Article history Received: 03 May 1991 Revision received: 25 July 1991 Accepted: 16 August 1991 Published: 20 November 1991
Alzheimer's disease.
Authors: M Rossor
Journal: BMJ (1993)

All patients with dementia should be investi- gated fully * The commonest cause of dementia is Alzheimer's disease * Alzheimer's disease can be diagnosed with certainty only on histology * Deposition of 3 amyloid protein is a central feature * Some rare familial cases are associated with mutations in the amyloid precursor protein gene * Associated neurotransmitter deficits, such as for acetylcholine, are amenable to treatment Box 1-Clinical syndrome ofdementia * Acquired deficit of cognition * Multiple domains of cognitive impairment * Must include memory impairment * Cognitive impairment not due to disturbance of arousal * Can be reversible For criteria of of dementia see
Bronchodilators.
Journal: BMJ (1970)

Miscellaneous DisordersIschaemic Myopathy.-Infarction of muscle may take place as a result of arterial embolism or thrombosis.It also may occur as a consequence of arterial damage related to closed fractures of a limb, usually supracondylar fractures of the humerus or fractures at the upper end of the femur.Fibrotic shortening of the muscle may ensue, as for instance in Volk- mann's ischaemic contracture of the forearm muscles seen following damage to the brachial artery with fractures in the region of the elbow.Muscle infarction also occurs in poly- arteritis nodosa and can contribute to the muscle weakness and wasting that may develop in this disease, in addition to that caused by vascular lesions of the peripheral nerve trunks.The anterior tibial syndrome consists of severe pain in the muscles of the anterolateral compartment of the lower leg after vigorous or unaccustomed exercise.It is considered to be the result of muscle swelling and consequent ischaemia as the muscles are contained within an inelastic fibro-sseous space.Infarction of muscle may take place, leading to persistent weakness, but is possibly preventable by surgical decompression of the compartment.Myoglobinuria.-Release of myoglobin because of acute des- truction of muscle fibres may cause myoglobinuria, which can lead to acute renal failure.Myoglobinuria is seen from a wide variety of causes, including extensive crush injury or infarction of muscle, acute polymyositis, hypokalaemic paralysis, and acute alcoholic myopathy.The occurrence of myoglobinuria on exercise in McArdle's disease has already been mentioned.Exercise may be a provocative factor in acute idiopathic myo- globinuria, in which the nature of the metabolic disturbancehas not yet been defined.