tbuckley/cabot-search huggingface dataset:
THE EFFECTS OF SUPERFICIAL BURNS
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic Inhalation Study of Fiber Glass and Amosite Asbestos in Hamsters: Twelve-Month Preliminary Results
Authors: T. W. Hesterberg, C. Axten, E. E. McConnell, G. Oberdorster, J. Everitt, W. C. Miiller, J. Chevalier, G. R. Chase, P. Thevenaz
Journal: Environmental Health Perspectives (1997)
Arterial Hypertension
Authors: GEORGE C.  HALE
Journal: Annals of Internal Medicine (1929)

Article1 November 1929Arterial HypertensionGEORGE C. HALEGEORGE C. HALESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-5-478 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptArterial hypertension, according to the dictionary, means abnormally high blood pressure. Now the original comprehension of the term, blood pressure, was the pressure of the blood upon the arterial wall such as would be recorded by a canula inserted into an artery and attached to a manometer. This is not practical from the clinical point of view, and as the possibility of error in the estimation of this pressure by the clinician's finger was great, the sphygmomanometer, or blood pressure apparatus with which we are all familiar, was introduced and has come to be a part of almost every physician's...Bibliography1. ROWNTREE LG: Med. Clin. of N. Am., 1928, May. Google Scholar2. FAHR G: Am. Jour. Med. Sci., 1928, April. Google Scholar3. SMITHLIGGETT : Med. Clin. of N. Am., 1927, Sept. Google Scholar4. ALLBUTT C: Diseases of the Arteries. Google Scholar5. RUSSELL W: The Sphygmometer. 1921. Google Scholar6. BELLCLAWSON : Archiv. of Path., 1928, June Google Scholar7. DOUTHWAITE AH: Guys Hosp. Reports, 1928, Jan. Google Scholar8. LUKIN N: Ann. Int. Med., 1927, Sept. Google Scholar9. BARATH E: Archiv. Int. Med., 1928, Aug. Google Scholar10. MEAKINS J: Physiol. Rev., 1927, July. Google Scholar11. ADAMSBROWN : Ann. Clin. Med., 1927, May. Google Scholar12. SHAW B: Hyperpiesia and Hyperpiesis. 1922. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London, Ontario*Read before the Boston Meeting of the American College of Physicians, April 10, 1929. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1929Volume 3, Issue 5Page: 478-482KeywordsArteriesBlood pressureHypertensionPrimary hypertension ePublished: 1 December 2008 Issue Published: 1 November 1929 PDF downloadLoading ...
Evidence of Functional Myocardial Ischemia Associated With Myocardial Dysfunction in Brain-Dead Pigs
Authors: Carole Seguin, Yvan Devaux, Sandrine Grosjean, El Medhy Siaghy, Pierre Mairose, Faiez Zannad, Nicole de Talancé, Dan Ungureanu-Longrois, Paul Michel Mertes
Journal: Circulation (2001)

Background Cardiac dysfunction after brain death has been documented, but its mechanisms remain unclear. Myocardial ischemia has been suggested as a possible cause. The aim of the present study was to investigate the existence of an imbalance between myocardial oxygen delivery and demand as a possible cause of myocardial dysfunction in brain-dead pigs. Methods and Results Interstitial myocardial lactate and adenosine concentrations were assessed with cardiac microdialysis in 2 groups of animals: brain-dead pigs (n=7) and brain-dead pigs treated with labetalol (10±3 mg/kg) (n=7). Heart rate (HR), left ventricular (LV) dP/dt max , rate-pressure product (RPP), cardiac output (CO), and left anterior descending coronary artery blood flow (QLAD) were continuously monitored. Brain-dead pigs exhibited a transient significant increase in HR, LV dP/dt max , RPP, and CO and a limited increase in QLAD. This resulted in functional myocardial ischemia attested to by the significantly increased adenosine and lactate microdialysate concentrations. In brain-dead pigs treated with labetalol, there was a moderate increase in HR, QLAD, and adenosine microdialysate concentrations; LV dP/dt max , RPP, CO, and myocardial lactate concentrations remained stable, confirming the preservation of aerobic metabolism. Conclusions Brain death was associated with an increase in myocardial interstitial adenosine and lactate concentrations, as well as with myocardial dysfunction; all were attenuated by labetalol, suggesting an imbalance between oxygen consumption and oxygen delivery as a possible cause of myocardial dysfunction after brain death.
Stockholm speakers on adolescents and AIDS: 'catch them before they catch it'
Authors: M. F. Goldsmith
Journal: JAMA (1988)

THE NEXT GENERATION of persons with acquired immunodeficiency syndrome (AIDS) is getting sick now. The number of adolescents infected with human immunodeficiency virus (HIV) is rising slowly but steadily around the world, according to reports presented in Stockholm at the Fourth International Conference on AIDS. In contrast to children born to infected mothers or those who have acquired the disease from contaminated blood products, today's teenagers who will be tomorrow's AIDS statistics could avoid catching the virus. In contrast to the many homosexual men (and some intravenous [IV] drug users) who have reportedly ceased their high-risk behavior in response to the AIDS threat, self-perceived "invulnerable" teenagers continue living dangerously. Whether the problem is lack of information, lack of belief, or something else is debated. But eight years into the epidemic, adults who care are arming themselves with facts and figures and refining educational strategies they hope will help adolescents stay
Dietetics for the Clinician
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE EPINEPHRIN TEST IN RELATION TO THE THYROID GLAND
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Moral medicine and universal health care
Authors: I. Emanuel
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The Editorial<sup>1</sup>"Crisis, Ethics, and the American Medical Association: 1947 and 1997" was important and timely. However, I do not believe that "[t]he main challenge facing medicine today is to ensure that free-market medicine remains moral medicine." On the contrary, I believe that the main challenge of American medicine is to use its influence to promote the development of a universal health care system in this country. "Moral medicine" is more easily assured in a universal system. That the medical establishment has missed every window of opportunity over the past half century to foster its development is probably one reason for the crisis in free-market medicine. Conditions in the United States stand in stark contrast to those in Taiwan, which has a universal health insurance system, described in the same issue.<sup>2</sup>Taiwan was a third-world country 3 decades ago and now has a successful industrial
Abstract 3213: Acarbose, an <i>α</i> -glucosidase Inhibitor, Reduces Myocardial Infarct Size in Rabbits via Stimulation of GLP-1 Receptors, Opening Mitochondrial KATP Channels, and Preventing Hydroxyl Radical Production
Authors: Shinya Minatoguchi, Hiroaki Ushikoshi, Narantuya Bao, Hiroyuki Kobayashi, Shinji Yasuda, Masamitsu Iwasa, Shouhei Sumi, Zengi Zhang, Kazuhiko Nishigaki, Genzou Takemura, Takako Fujiwara, Hisayoshi Fujiwara
Journal: Circulation (2008)

Background: Acarbose, an anti-diabetic drug, is an α– glucosidase inhibitor that can inhibit glucose absorption in the intestine. A recent large-scale clinical trial, STOP-NIDDM, showed that acarbose reduces the risk of myocardial infarction. We examined whether acarbose reduces myocardial infarct size and investigated its mechanisms. Methods and Results: Rabbits were fed with one of four diets in this study: normal chow, 30 mg acarbose/100 g chow, 8 g sucrose/100 g chow, or 30 mg acarbose plus 8 g sucrose/100 g chow for 7 days. Rabbits were assigned randomly to one of eight groups: control (n=10), acarbose (n=10), sucrose (n=10), acarbose+sucrose (n=10), acarbose+i.v. 5-hydroxydecanoate (5HD, a mitochondrial KATP channel blocker, 5 mg/kg) (n=10), 5HD (i.v. 5 mg/kg, n=10), acarbose+exendin(9 –39) (n=10, a Glucagon-Like Peptide-1(GLP-1) receptor blocker, 3 nmol/l) (45.4±1.2%) and exendin(9 –39)(n=10). Rabbits then underwent 30 min of coronary occlusion followed by 48 h reperfusion. Postprandial blood glucose levels were highest in the sucrose group and higher in the control groups, but decreased in the acarbose and sucrose+acarbose groups. The infarct size as a percentage of the left ventricular area at risk was reduced significantly in the acarbose (19.4±2.3%) and sucrose+acarbose groups (19.0±5.6%) as compared with the sucrose (47.4±4.2%) and control groups (42.8±5.4%). The infarct size-reducing effect of acarbose was abolished by 5HD (43.4±4.7%) and exendin(9 –39) (45.4±1.2%). The 5HD and exendin(9 –39) by itself did not affect the infarct size. Myocardial interstitial 2,5-DHBA levels, an indicator of hydroxyl radicals, increased during reperfusion after 30 min of ischemia but this increase was inhibited in the acarbose group. Conclusions: Acarbose reduces myocardial infarct size via stimulation of GLP-1 receptors, opening mitochondrial KATP channels, and preventing hydroxyl radical production.
Intensive therapy and progression to clinical albuminuria in patients with insulin dependent diabetes mellitus and microalbuminuria
Journal: BMJ (1995)

Abstract Objective: To study the effect of intensive therapy of diabetes on the progressio to clinical albuminuria in insulin dependent diabetic patients with microalbuminuria. Design: Randomised controlled clinical trial of intensive versus conventional therapy ofdiabetes for a median of 5 years (range 2-8). Setting: Nine hospital based specialist diabetes centres in England and Wales. Subjects: 70 European insulin dependent diabetic patients aged 17-59 years with microalbuminuria (albumin excretion 30-199 µg/min), but without arterial hypertension, recruited from the nine hospital based specialist diabetes centres. Interventions: Intensive diabetic therapy was allocated to 36 patients (27 men, 9 women) and conventional diabetic therapy to 34 (24 men, 10 women). Main outcome measures: Development of clinical albuminuria, defined as albumin excretion greater than 200 µg/min on at least two consecutive occasions, and rate of change of albumin excretion. Results: Mean glycated haemoglobin concentration, similar at baseline in the two groups (intensive therapy group 10.3% (SEM 1.9%), conventional therapy group 9.8% (1.6%)), fell significantly (by 14%) in the intensive therapy group only. A significant glycaemic separation between the two groups was maintained for up to three years. Progression to clinical albuminuria occurred in six patients in each group. Blood pressure, similar at baseline, fell significantly by 1 mm Hg (95% confidence interval −4.20 to 1.43) per year in the conventional therapy group, but the difference in the rate of blood pressure change between the groups was not significant. Independent of treatment assignment, a mean blood pressure above the group mean (93.6 mm Hg), but not the glycated haemoglobin concentration, predicted progression to clinical albuminuria (relative risk 4.2, 95% confidence interval 1.3 to 13.0). Conclusions: Intensive therapy with improved glycaemic control for three years had no impact on the progression of albuminuria in insulin dependent diabetic patients with microalbuminuria. The reduction in blood pressure in the conventional therapy group may have affected outcome--in that arterial blood pressure rather than glycated haemoglobin concentration seemed to be the main predictor of progression from microalbuminuria to clinical albuminuria.
Commentaire de travail de G. Longcroft-Wheaton et al., pp. 426
Journal: Endoscopy (2013)

See also:Duration of acetowhitening as a novel objective tool for diagnosing high risk neoplasia in Barrett’s esophagus: a prospective cohort trialEndoscopy 2013; 45(06): 426-432DOI: 10.1055/s-0032-1326630
Beta-2 Microglobulin Is an Amyloidogenic Protein in Man
Journal: Journal of Clinical Investigation (1986)

Curvilinear fibrils with the tinctorial properties of amyloid were isolated from a patient with bone and joint involvement compli- cating chronic dialysis for renal disease.Subunit fractions of 24,000 (A) and 12,000 (B) mol wt were identified after gel fil- tration under dissociating conditions, the former containing a significant amount of a dimer of the latter.This was confirmed
Lead Poisoning
Authors: Herbert Needleman
Journal: Annual Review of Medicine (2004)

Understanding of lead toxicity has advanced substantially over the past three decades, and focus has shifted from high-dose effects in clinically symptomatic individuals to the consequences of exposure at lower doses that cause no symptoms, particularly in children and fetuses. The availability of more sensitive analytic methods has made it possible to measure lead at much lower concentrations. This advance, along with more refined epidemiological techniques and better outcome measures, has lowered the least observable effect level until it approaches zero. As a consequence, the segment of the population who are diagnosed with exposure to toxic levels has expanded. At the same time, environmental efforts, most importantly the removal of lead from gasoline, have dramatically reduced the amount of lead in the biosphere. The remaining major source of lead is older housing stock. Although the cost of lead paint abatement is measured in billions of dollars, the monetized benefits of such a Herculean task have been shown to far outweigh the costs.
Assessing Confounding, Effect Modification, and Thresholds in the Association between Ambient Particles and Daily Deaths
Authors: Joel Schwartz
Journal: Environmental Health Perspectives (2000)

I examined the relationship between daily deaths and airborne particles in 10 U.S. cities with varying climatic conditions and seasons in which particle concentrations were high. Airborne particles were associated with significant increases in daily deaths [0.67% increase for a 10 microg/m(3) increase in particles; 95% confidence interval (CI), 0.52-0.81%]. This association was the same in summer and winter. To examine potential confounding by other pollutants, I regressed city- and season-specific effect sizes against the relationship between airborne particles and other pollutants. Controlling for other pollutants did not substantially (or significantly) change the estimated effect of airborne particles. Socioeconomic differences between cities likewise did not modify the effect. The increase in daily deaths that occurred out of hospitals (0.89% per 10 microg/m(3); CI, 0.67-1.10%) was substantially greater than the increase in deaths in hospitals (0. 49%; CI, 0.31-0.68%). This is consistent with results previously reported in Philadelphia, Pennsylvania, and suggests that the particle-associated deaths are not just being brought forward by a few days. It is also consistent with recent animal and human studies of the mechanisms of particle toxicity.
Comparative Laboratory and Clinical Observations on Two New Oral Penicillins, Oxacillin and Ancillin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WASHINGTON NEWS
Journal: JAMA (1964)

<h3>Record Number Hospitalized.—</h3> A record 25.3 million persons were hospitalized last year, almost 1 million more than in 1962, according to the American Hospital Association. The Health Insurance Institute noted this meant that in 1963 over 69,000 persons each day entered non-federal short-term general and other special hospitals, and that on an average day there were 533,000 patients—2.8 persons per 1,000 population— under hospital confinement. Data from the AHA also indicated that there were 698,000 beds available for patients in 1963, an average of 3.7 beds per 1,000 population. The association, which includes terminal hospitalizations in its survey, finds the average hospital stay for all ages to be 7.7 days. A study conducted by the US National Health Survey based on representative household interviews does not include terminal hospital stays and puts the average at 9.4 days. (Note: NHS data also include federal hospitals. ) According to the NHS, persons under
More on brain death
Authors: D. H. Mills
Journal: JAMA (1975)

ON SEPT 27, 1974, the governor of California approved a new brain death statute. It states: A person shall be pronounced dead if it is determined by a physician that the person has suffered a total and irreversible cessation of brain function. There shall be independent confirmation of the death by another physician. Nothing in this chapter shall prohibit a physician from using other usual and customary procedures for determining death as the exclusive basis for pronouncing a person dead. When a part of the donor is used for direct transplantation pursuant to the Uniform Anatomical Gift Act and the death of the donor is determined by determining that the person has suffered a total and irreversible cessation of brain function, there shall be an independent confirmation of the death by another physician. Neither the physician making the determination of death... nor the physician making the independent confirmation shall participate
Aquatic Toxicology: Fact or Fiction?
Authors: Kenneth J. Macek
Journal: Environmental Health Perspectives (1980)

A brief history of the development of the field of aquatic toxicology is provided. In order to provide a perspective on the state-of-the-art in aquatic toxicology relative to classical toxicology, the two fields are compared from the standpoint of the type of scientist practicing each field, the respective objectives of each, the forces which drive the activity in each field, and the major advantages and disadvantages accruing to the practitioner of aquatic toxicology as a result of the differences in objectives and driving forces.
Annual Review of Biochemistry. Volume I.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal