tbuckley/cabot-search huggingface dataset:
Treatment facility volume and survival in patients with advanced prostate cancer.
Authors: Shreyas Joshi, Elizabeth A. Handorf, Abhishek Srivastava, Selma Masic, David B. Cahn, Brian T. Kadow, Matthew R. Zibelman, Pooja Ghatalia, Robert Uzzo, Alexander Kutikov, Marc C. Smaldone, Richard E. Greenberg, Rosalia Viterbo, David Chen, Eric M. Horwitz, Mark A Hallman, Mark Leslie Sobczak, Daniel M. Geynisman
Journal: Journal of Clinical Oncology (2019)

274 Background: Despite improvements in the medical management of advanced prostate cancer (aPC), it continues to be the 2 nd leading cause of cancer death in American men. The contemporary management of men with aPC is increasingly complex and can vary based on access to up-to-date treatments, which is often found at busier treatment centers. We thus evaluated the relationship between facility volume and survival outcomes in aPC. Methods: The National Cancer Database (NCDB) was queried from 2004-2014 for aPC, defined as T4, N+, or M+ disease. Six pre-defined patient cohorts were evaluated. Cohort A = patients with aPC (N = 64,815); cohort B = M0 patients (N = 27,155); cohort C = M0 patients undergoing active treatment (N = 21,755); cohort = all M1 patients (N = 37,660); cohort E = M0 patients undergoing active treatment (N = 30,643); and cohort F = M1 patients who underwent active treatment and who had known metastatic sites (N = 12,452). Treatment facilities were divided into quartiles based on median treatment volume: &lt;1.8 patients/year, 1.8-3.3 patients/year, 3.4-5.6 patients/year, and &gt;5.6 patients/year. Regression models were adjusted along a set of covariates available in the NCDB. The primary outcome was overall survival (OS). Results: OS improved with each increase in volume quartile. The top quartile (&gt;5.6 pts/yr) demonstrated significantly greater OS compared to the bottom quartile (&lt;1.8 pts/yr) [HR 0.82, 95% CI 0.77-0.88, p&lt;0.001]. The improved OS in the top volume quartile remained consistent when analyzed across the six pre-defined patient cohorts. Sensitivity analyses were conducted on Cohort A, adjusting for Gleason score and facility type, which did not change the effect of volume on survival. Conclusions: In this retrospective analysis of nearly 65K men who presented with aPC, we demonstrate that management at a high-volume facility (top quartile, &gt;5.6 pts/yr) confers a significant OS advantage when compared to management at a facility in the lowest quartile (&lt;1.8 pts/yr). This OS advantage persisted with similar magnitudes of effect after narrowing the cohorts by disease and treatment characteristics. These findings may have implications on the optimal management of men with advanced PC.
Status Asthmaticus In Children
Authors: Warren Richards
Journal: JAMA (1968)

<h3>To the Editor:—</h3> In a recent letter to the editor, Dr. Fontana, in reference to our paper, "Status Asthmaticus in Children" (<b>201</b>:75, 1967), criticized our recommendation that "corticosteroids be promptly administered to all patients with status asthmaticus." He further implied that this position was not representative of other allergists' views. In explaining his stand, he condemned the indiscriminate use of steroids and advised reserving them for "life-saving situations." We are in total agreement with this contention! On the other hand, our experiences contrast sharply with regard to the management of status asthmaticus in children. It is now widely accepted that status asthmaticus is often a life-threatening situation whether or not the patient previously had received steroid therapy and, consequently, that steroids should be used for this critical complication of asthma.<sup>1-3</sup>In addition, because of the potential danger of adrenal insufficiency, with-holding of steroids for the treatment of status
Erratum
Authors: L.A. Demers-Desrosiers, K.R. Cohen, R.F.H. Catchlove, R.A. Ramsay, K.R. Cohen, L.A. Demers-Deswsiers, R.F.H. Catchlove, Richard F.H. Catchlove, Ronald Grossarth-Maticek, Dusan T. Kanazir, Hermann Vetter, Miroslav Jankovic, Christa Schreiber, Irmela Florin, Wolfgang Rost, Catherine J. Green, Theodore Millon, Robert B. Meagher, Jr., Stuart Shipko, William A. Alvarez, Nicholas Noviello
Journal: Psychotherapy and Psychosomatics (1983)
Incorrect placement of intracaval prosthesis for pulmonary embolism
Authors: E. A. Gaston
Journal: JAMA (1970)

<h3>To the Editor.—</h3> The intracaval insertion of a filtering prosthesis has been reported to be effective in preventing pulmonary emboli.<sup>1-3</sup>It can be inserted under local anesthesia through a small wound in the neck, an advantage in critically ill patients. The following case is reported because, by misadventure, a prosthesis was placed in the right common iliac vein. Two days later a second prosthesis was fixed in the inferior vena cava. The second prosthesis was well tolerated and its insertion corrected the technical error. <h3>Report of a Case.—</h3> A 72-year-old man entered the Framingham (Mass) Union Hospital after one week of abdominal discomfort. His history included recurrent duodenal ulcer, myocardial infarction, emphysema, angina pectoris, and mild diabetes. On examination the diameter of the chest was increased. The blood pressure was 184/90 mm Hg. The abdomen was moderately distended but there was no tenderness and peristalsis was present. X-ray films
Human herpesvirus type 8-positive facial angiosarcoma developing at the site of botulinum toxin injection for blepharospasm
Authors: S. Karpati, S. Desaknai, M. Desaknai, J. Biro, K. Nagy, A. Horvath
Journal: British Journal of Dermatology (2000)

Journal Article Human herpesvirus type 8‐positive facial angiosarcoma developing at the site of botulinum toxin injection for blepharospasm Get access S. Kárpáti, S. Kárpáti Department of Dermato‐Venereology, Semmelweis Medical University, Mária u. 41, 1085 Budapest, Hungary Search for other works by this author on: Oxford Academic Google Scholar S. Désaknai, S. Désaknai Department of Dermato‐Venereology, Semmelweis Medical University, Mária u. 41, 1085 Budapest, Hungary Search for other works by this author on: Oxford Academic Google Scholar M. Désaknai, M. Désaknai Department of Dermato‐Venereology, Semmelweis Medical University, Mária u. 41, 1085 Budapest, Hungary Search for other works by this author on: Oxford Academic Google Scholar J. Bíró, J. Bíró Department of Dermato‐Venereology, Semmelweis Medical University, Mária u. 41, 1085 Budapest, Hungary Search for other works by this author on: Oxford Academic Google Scholar K. Nagy, K. Nagy National Institute of Dermato‐Venerology, Budapest, HungaryE‐mail: karsar@bor.sote.hu Search for other works by this author on: Oxford Academic Google Scholar A. Horváth A. Horváth Department of Dermato‐Venereology, Semmelweis Medical University, Mária u. 41, 1085 Budapest, HungaryNational Institute of Dermato‐Venerology, Budapest, HungaryE‐mail: karsar@bor.sote.hu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 3, 1 September 2000, Pages 660–661, https://doi.org/10.1111/j.1365-2133.2000.03739.x Published: 01 September 2000
Therapeutic Pancreatic Endoscopy
Authors: K. Mergener, R. Kozarek
Journal: Endoscopy (2005)

Over the past decade, endoscopic retrograde cholangiopancreatography (ERCP) has developed from being a diagnostic tool to become one that is primarily used to provide therapy. This development occurred first for biliary disorders and more recently for primary diseases of the pancreas. Not only can new-generation computed tomography (CT), magnetic resonance imaging, and magnetic resonance cholangiopancreatography procedures suggest a diagnosis in the majority of individuals with pancreatic diseases today; in addition, ERCP-related complications can be minimized or avoided altogether in conjunction with positron-emission tomography or directed cytology or biopsy, either using ultrasound or CT guidance, or with tissue obtained during endoscopic ultrasonography. It is against this background that papers on therapeutic pancreatic endoscopy published during approximately the last year are reviewed here. Despite these developments, however, the following three issues concerning current advances in pancreatic endotherapy should be emphasized: firstly, most of the techniques reviewed here affect only a small number of patients; secondly, most of the techniques have been reported only by expert centers; and thirdly, most of the studies concerned have lacked control groups, and there is still a paucity of studies investigating endoscopic techniques on a randomized basis in comparison with surgery or medical therapy for the treatment of most benign and malignant pancreatic disorders.
An epidemic in an Eskimo village due to group-B meningococcus. 2. Clinical features
Authors: T. H. Corbett
Journal: JAMA (1966)

Six cases of meningococcemia with unusual clinical manifestations occurred in Barrow, Alaska, in October and November 1964. Four of the six cases were in adults, and two of these were fatal. Meningitis, as defined by white blood cells in the spinal fluid, was not seen.
Higher Folic Acid Intake Needed
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Wording
Authors: Benjamin Druss, Robert Rosenheck
Journal: JAMA (2000)

In Reply: Mr Barzilai and Dr Rimm propose 2 interesting and testable hypotheses: first, that physician referrals might be a major factor underlying the relationship between the 2 types of care, and second, that uninsured patients might use these therapies differently than those with health insurance do.The TABLE shows the multivariate analysis modeling use and quantity of physician visits as a function of unconventional service use in 2 subgroups: patients not reporting a physician referral for unconventional treatment and patients without insurance.In each of these subsamples, having an unconventional visit is strongly associated with physician visits, although the magnitude of these associations is somewhat smaller than for the entire sample.These findings suggest that insurance status and physician referrals may partly mediate, but are not the primary factors driving, the association between the 2 systems of care.Dr Katz addresses a potentially important avenue for additional research-evaluating systems of care that integrate conventional and unconventional treatments.As more data become available on the effectiveness of specific unconventional therapies, it will become possible to design systems incorporating the best of these treatments into mainstream medical care, and to study the impact of these integrated systems on patient satisfaction, cost and use, and health outcomes.
Visualization of the Renal Artery: Comparison of Translumbar and Percutaneous Retrograde Catheter Approaches, Single Film and Seriographic Techniques
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histoplasmosis Primary to the Larynx
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Race and Ethnicity: A Compelling Research Agenda
Authors: Herbert Nickens
Journal: Annals of Internal Medicine (1997)

Letters1 February 1997Race and Ethnicity: A Compelling Research AgendaHerbert Nickens, MD, MAHerbert Nickens, MD, MAAssociation of American Medical Colleges, Washington, DC 20037Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-3-199702010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Bauer misunderstands my reference to affirmative action and by extension reveals a misunderstanding of the reality of racial and ethnic minorities in the United States. In my view, Dr. Bauer makes at least two mistakes.First, my comment did not so much express support for affirmative action as point out that our society is currently engaged in a fierce debate about affirmative action; one of the core disagreements in that debate is whether race or ethnicity is still a relevant way to distinguish among persons or whether our society has become race-blind. The three articles on which ...References1. Escarce JJ, Epstein KR, Colby DC, Schwartz JS. Racial differences in the elderly's use of medical procedures and diagnostic tests. Am J Public Health. 1993; 83:948-54. Google Scholar2. Gornick ME, Eggers PW, Reilly TW, Mentnech RM, Fitterman LK, Kucken LE, et al. Effects of race and income on mortality and use of services among Medicare beneficiaries. N Engl J Med. 1996; 335:791-9. Google Scholar3. Krieger N, Sidney S. Racial discrimination and blood pressure: the CARDIA study of young black and white adults. Am J Public Health. 1996; 86:1370-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Association of American Medical Colleges, Washington, DC 20037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDisorders/diseases of nature and nurture: How can public health be best advanced? 1 February 1997Volume 126, Issue 3Page: 252KeywordsArteriolesHealth careHypertensionMedical educationMedical servicesRacial and ethnic discriminationRacial and ethnic issues Issue Published: 1 February 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
PYRETHRUM
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of colore doppler energy in the diagnosis of small hepatocellular carcinoma Institute of Gastroenterology, Tokyo Women's Medical College, Tokyo, Japan
Journal: Hepatology (1995)

The incidence of cardiovascular disease is lower in premenopausal women compared with men; following menopause, the risk of mortality from cardiovascular disease increases in females. Postischemic dilatation of the brachial artery has been used previously as an index of endothelium-mediated vasodilation. Using this index, we examined a group of premenopausal and postmenopausal women, some of whom were on estrogen replacement therapy (ERT). All subjects were normotensive (blood pressure [BP] < 140/90mm Hg) and normoglycemic (blood glucose, < 100mg/dL). Fourteen healthy women (mean age, 27 ± 0.8 years; mean total cholesterol, 174 ± 6.7 mg/dL) and fourteen healthy men (mean age, 26 ± 1.4 years; mean total cholesterol, 181 ± 7.2 mg/dL) were investigated. Nineteen postmenopausal women were also examined; 11 were on ERT (mean age, 55 ± 2.1 years; mean total cholesterol, 213 ± 6.6 mg/dL) and eight were not on ERT (mean age, 60 ± 3.6 years; mean total cholesterol, 222 ± 14.4 mg/dL). Ischemia was induced by inflating a cuff over the forearm to a pressure of 40 mm Hg above systolic for 5 minutes. Doppler ultrasonography (Acuson [Mountain View, CA] 128XP/10c ultrasonograph with a 7.5-MHz linear array transducer) was used to measure the brachial artery diameter before inflation and 15 seconds and 45 to 60 seconds following cuff deflation. Flow-mediated dilatation (FMD%) and hyperemia were defined as the percentage increase over basal diameter and basal flow, respectively. Postischemic median dilatation in men was 4.20% (interquartile range, 2.13% to 5.56%) and 11.48% (interquartile range, 8.70% to 14.29%) in age-matched premenopausal women (P < .01). For women on ERT, the postischemic median dilatation was 8.11% (interquartile range, 6.01% to 11.60%), as compared with 2.82% (interquartile range, 1.32% to 3.28%) for women without ERT (P < .01). Premenopausal women showed significantly greater dilatation after ischemia than postmenopausal women without ERT (P < .0001). Hyperemia was similar in all groups. These findings show that postischemic vasodilation of the brachial artery is greater in premenopausal women versus age-matched men; it is decreased in postmenopausal women, and ERT restores it toward normal. The pathophysiology underlying the diminution in postischemic dilatation may be relevant to atherogenesis and coronary artery disease (CAD).
Developing Clues to Environmental Cancer: A Stepwise Approach with the Use of Cancer Mortality Data
Authors: William J. Blot, Joseph F. Fraumeni, Thomas J. Mason, Robert N. Hoover
Journal: Environmental Health Perspectives (1979)

Clues to environmental determinants can often be derived from the patterns of mortality from cancer. This review focuses on the stepwise approach of using cancer mortality maps, supplemented by correlation studies linking mortality rates with demographic and industrial data at the county level, to generate hypotheses to cancer etiology which can then be pursued by analytical epidemiological studies. Advantages and limitations of this approach and its application in the study of lung cancer in the United States are described.
B7-1, B7-2 and class II MHC molecules in idiopathic pulmonary fibrosis and bronchiolitis obliterans-organizing pneumonia
Authors: Y. Kaneko, K. Kuwano, R. Kunitake, M. Kawasaki, N. Hagimoto, N. Hara
Journal: European Respiratory Journal (2000)

Interstitial lung diseases are thought to be associated with the infiltration of activated T-lymphocytes. To induce an effective immune response, antigen-presenting cells have to not only present antigenic peptide with major histocompatibility complex (MHC) molecules to T-lymphocytes but also express B7 molecules. Therefore, the expression of B7-1, B7-2 and class II MHC molecules was investigated in lung tissues from patients with idiopathic pulmonary fibrosis (IPF) and bronchiolitis obliterans-organizing pneumonia (BOOP), and in normal lung parenchyma as a control, using immunohistochemical localization. B7-1 and B7-2 were aberrantly expressed in bronchiolar and alveolar epithelial cells, and class II MHC molecules were also aberrantly expressed in bronchiolar epithelial cells in IPF. B7-1 was aberrantly expressed in bronchiolar epithelial cells in BOOP. There was no significant difference in the expression of these proteins in alveolar macrophages between IPF and control subjects. However, B7-2 and class II MHC molecule expression in alveolar macrophages was decreased in BOOP compared with that in control subjects. Expression of CD28 and CTLA4, receptors for B7 molecules, was detected in infiltrating lymphocytes in lung tissues in IPF and BOOP. It was concluded that bronchiolar and alveolar epithelial cells may actively participate in the pathophysiology of idiopathic pulmonary fibrosis through the aberrant expression of B7 and class II major histocompatibility complex molecules. The dysregulation of these molecules in epithelial cells may lead to the activation of autoreactive T-lymphocytes, which might contribute to the pathogenesis of fibrosing lung diseases.
Biotechnology in Healthcare
Authors: Roger Walker
Journal: BMJ (1999)

Ed Gavin Brooks Pharmaceutical Press, £19.95, pp 228 ISBN 085369 372 2 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> “Wrong man, wrong book to review,” I thought on receiving Biotechnology in Healthcare , “What's the relevance of this to a clinician or a health authority bureaucrat like me?” But on the plus side, it was only 228 pages long and had a statement on the cover that it was written for the healthcare profession, so I accepted the invitation to review. For those a little rusty on … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif