tbuckley/cabot-search huggingface dataset:
Use of fMRI to Predict Recovery From Unipolar Depression With Cognitive Behavior Therapy
Authors: Greg J Siegle, Cameron S Carter, Michael E Thase
Journal: American Journal of Psychiatry (2006)

Objective: In controlled treatment trials, 40%–60% of unmedicated depressed individuals respond to cognitive behavior therapy (CBT). The authors examined whether pretreatment neural reactivity to emotional stimuli accounted for this variation. Method: Unmedicated depressed individuals (N=14) and never depressed comparison subjects (N=21) underwent fMRI during performance of a task sensitive to sustained emotional information processing. Afterward, depressed participants completed 16 sessions of CBT. Results: Participants whose sustained reactivity to emotional stimuli was low in the subgenual cingulate cortex (Brodmann’s area 25) and high in the amygdala displayed the strongest improvement with CBT. Conclusions: The presence of emotion regulation disruptions, which are targeted in CBT, may be the key to recovery with this intervention.
Biochimica et Biophysica Acta, Amsterdam
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INDIVIDUAL RISK CALCULATOR TO PREDICT LYMPH NODE METASTASES IN PATIENTS WITH SUBMUCOSAL (T1B) ESOPHAGEAL ADENOCARCINOMA: MULTICENTER COHORT STUDY
Authors: SEM van de Ven, AW Gotink, FJC Ten Kate, D Nieboer, BLAM Weusten, LAA Brosens, R van Hillegersberg, LA Herrero, CA Seldenrijk, A Alkhalaf, FCP Moll, EJ Schoon, I van Lijnschoten, T Tang, H van der Valk, WB Nagengast, G Kats-Ugurlu, JTM Plukker, MHMG Houben, J van der Laan, RE Pouw, JJGHM Bergman, SL Meijer, MI van Berge Henegouwen, BPL Wijnhoven, PJF de Jonge, M Doukas, MJ Bruno, K Biermann, AD Koch
Journal: Endoscopy (2020)

Aims A prognostic model may help to identify patients at risk for lymph node metastases (LNM) in order to stratify between a conservative approach or additional surgery, after endoscopic resection of pT1b esophageal adenocarcinoma (EAC). The aim of this study was to develop a prediction model for the risk LNM or distant metastases in patients with pT1b EAC.
Screening for Lung Cancer
Authors: David M. Eddy
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 January 1990Screening for Lung CancerDavid M. Eddy, MD, PhDDavid M. Eddy, MD, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-1-73 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Two letters commenting on my article on lung cancer screening (1) raise specific points that deserve further discussion. First, I disagree with Drs. Melamed and Flehinger (2) that all three of the National Cancer Institute-(NCI) sponsored trials were designed only to assess the value of sputum cytology when added to chest roentgenograms. The Mayo Lung Project compared one group screened with chest roentgenograms and sputum cytology delivered every 4 months with a control group not offered any active screening. (Some might have received screening outside the trial.) This point is important; it means that the Mayo Lung...References1. Eddy D. Screening for lung cancer. Ann Intern Med. 1989;111:232-7. LinkGoogle Scholar2. MelamedFlehinger MB. Screening for lung cancer [Letter]. Ann Intern Med. 1989;111:764-5. LinkGoogle Scholar3. FlehingerKimmel BM. The natural history of lung cancer in a periodically screened population. Biometrics. 1987;43:127-44. CrossrefMedlineGoogle Scholar4. TockmanMulshineSmart MJC. Screening for lung cancer [Letter]. Ann Intern Med. 1989;111:765-6. Google Scholar5. MulshineTockmanSmart JMC. Considerations in the development of lung cancer screening tools. J Natl Cancer Inst. 1989;81:900-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Duke University Durham, NC 27706 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLung Cancer Screening With Helical Computed Tomography in Older Adult SmokersComputed tomography screening for lung cancerCT SCREENING FOR LUNG CANCERScreening for Lung CancerRadiographic screening for cancer proposed paradigm for requisite research 1 January 1990Volume 112, Issue 1Page: 73-74KeywordsCancer screeningCell biologyLung and intrathoracic tumorsLung cancer screeningLungsSputumThorax Issue Published: 1 January 1990 PDF DownloadLoading ...
Carbon tetrachloride toxicity potentiated by isopropyl alcohol. Investigation of an industrial outbreak
Authors: D. S. Folland
Journal: JAMA (1976)

Fourteen workers in an isopropyl alcohol packaging plant became ill after accidental exposure to carbon tetrachloride. In four, renal failure or hepatitis developed. Isopropyl alcohol potentiation of carbon tetrachloride toxicity has been shown previously only in rats. Acetone, a product of isopropyl alcohol metabolism, is a major potentiator of carbon tetrachloride toxicity. Workers had elevated levels of acetone in samples of expired alveolar gas and thus were metabolically predisposed to carbon tetrachloride injury. Stricter limits for industrial carbon tetrachloride exposure should be established where concomitant isopropyl alcohol use occurs. (<i>JAMA</i>236:1853-1856, 1976)
The British Hepatic Angiosarcoma Register
Authors: Peter J. Baxter
Journal: Environmental Health Perspectives (1981)

A register of British cases of primary hepatic angiosarcoma (HAS) was established in 1974 to monitor the occurrence of cases from 1963 onwards. Details of cases dying in 1963-77 have been obtained. Thirty-five cases were agreed as HAS by panel of liver pathologists, and occupational and medical information was obtained in the majority of these. Two cases were attributable to VCM exposure, and eight others had received intra-arterial Thorotrast. In 1978-79, two more cases were confirmed in VCM polymerization workers.
A comparison between ventricular and lumbar cerebrospinal fluid cytology in adult patients with leptomeningeal metastases
Authors: Marc C. Chamberlain, Patty A. Kormanik, Michael J. Glantz
Journal: Neuro-Oncology (2001)

Leptomeningeal metastases (LMs) are common metastatic complications, occurring in at least 5% of patients with disseminated cancer.Cerebrospinal uid (CSF) cytology remains the standard for diagnosis and assessment of treatment response, but may be inadequate.Our objective was to compare ventricular and lumbar CSF cytology in patients who had cytologically proven LM and were receiving intra-CSF chemotherapy.Sixty patients with LM, positive lumbar CSF cytology documented at diagnosis, limited extent of CNS disease, and no evidence of CSF ow obstruction were treated with a variety of intra-CSF chemotherapies.All patients underwent a single simultaneous ventricular and lumbar CSF sampling (mean volume of CSF per site examined, 10 ml) to assess response to therapy at either 1 or 2 months after treatment initiation.Ventricular CSF cytology was positive in 44 patients (73%), 35 of whom were also positive by lumbar CSF cytology.Lumbar CSF cytology was positive in 45 patients (75%), of which 35 were also positive by ventricular CSF cytology.Samples were negative at both ventricular and lumbar sites in 6 patients (10%).Paired CSF cytologies were discordant in 19 (32%) patients.The lumbar cytology was negative in 9, whereas the ventricular cytology was positive (lumbar false-negative rate of 17%); the ventricular cytology was negative in 10, whereas the lumbar cytology was positive (ventricular false-negative rate of 20%).In the presence of spinal signs or symptoms of LM, the lumbar CSF cytol-
Chirurgie de l'oeil et de ses annexes.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorporation of a comprehensive geriatric assessment (CGA) into a randomized phase III trial for metastatic breast cancer (MBC): The PELICAN study.
Authors: M. De Wit, F. Honecker, U. Wedding, D. Waldenmaier, J. Dorn, M. Warm, S. Al-Batran, M. Schmidt, R. Kreienberg, N. Harbeck
Journal: Journal of Clinical Oncology (2010)

1070 Background: PELICAN is a randomized phase III trial evaluating efficacy and safety of pegylated liposomal doxorubicin (PLD) vs. capecitabine (CAP) as first-line therapy in patients (pts) with MBC. CGA results and correlation to time to progression (TTP), overall survival (OS), and time to treatment failure (TTF) were evaluated. Methods: CGA comprised data on activities of daily living (ADL), instrumental sctivities of daily living (IADL), Karnofsky performance status (KPS), comorbidity (CIRS-G), and the number of comedications. According to CGA, pts were classified into 3 groups. Single and combined CGA items were analyzed for association with treatment burden and efficacy outcome (TTP, OS, TTF) using Fisher's exact test, Wilcoxon test, and logistic regression. Results: Data from 210 pts (105 PLD, 105 CAP) with a median age of 62 y (22-85) were analyzed. 123 pts (59%) were <65 y and 87 pts (41%) ≥65 y. CGA scores were available from 152 pts. According to CGA, 113 pts were considered fit (group 1, 74%), 15 compromised (group 2, 10%), and 24 frail (group 3, 16%). Pts with a good KPS (≥ 90%) (n=46) had a significantly longer TTP vs. pts with a worse KPS (n=44) (median KPS 100%: 8.7 mo; 90%: 8.6 mo; ≤ 90%: 3.8 mo; p=0.0027). CGA, ADL, and IADL scores, and CIRS-G did not have a significant impact on TTP. In terms of OS, a high KPS (≥ 90%) significantly increased OS (median 100%: 27.5 mo; 90%: 32.1; <90%: 18.4 mo; p=0.0034). IADL score 8 and CIRS-G 0-3 also correlated with longer OS vs. IADL score <8 (24.1 vs. 17.8 mo, p=0.0061) and CIRS-G >3 (median 0-1: 30.0 mo; 2-3: 32.1 mo; >3: 17.8 mo; p<0.0001). A high KPS increased TTF significantly (median 100%: 5.8.mo; 90%: 4.6 mo, ≤ 90%: 3.0 mo; p=0.0076). Pts with IADL score <8 had a longer TTP (13.7 vs 2.6 mo, p=0.0272), OS (22.7 vs. 4.0 mo, p=0.0031) and TTF (4.6 vs. 2.5 mo, p=0.0043) in the PLD vs. CAP arm. Conclusions: KPS was the most striking predictive factor in this analysis with respect to correlation to TTF and OS. Pts with IADL score <8 treated with PLD had better outcome than pts in CAP arm. Incorporation of CGA into a phase III trial is feasible and yields valuable information for deciding best therapy for MBC patients. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Essex Pharma Essex Pharma, Schering-Plough Essex Pharma, Schering-Plough Schering-Plough, University Hospital Hamburg-Eppendorf Schering-Plough
The Washing
Authors: Mark Mosley
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Botulinum toxin may help blepharospasm sufferers
Authors: H. Cole
Journal: JAMA (1985)

Local injection of a potent poison—<i>Clostridium botulinum</i>toxin—may bring relief to sufferers of benign essential blepharospasm (<i>Arch Ophthal</i>1985;103:347-350). This disorder, which tends to afflict persons of middle years and beyond, is characterized by an involuntary spasm of (usually) both obicularis oculi muscles, resulting in uncontrollable eyelid closure and functional blindness. Botulinum toxin, which acts by blocking the release of acetylcholine from the presynaptic nerve terminal, causes paralysis of the overactive facial muscles, allowing the eyes to remain open. Alan B. Scott, MD, associate director, Smith-Kettlewell Institute of Visual Sciences, Medical Research Institute of San Francisco, told the Research to Prevent Blindness seminar of results of a collaborative study, supported in part by the National Eye Institute, of 442 patients afflicted with this disorder. Beneficial effect of the botulinum toxin therapy has been reported in over 90% of the patients. A preparation of the toxin (.001μg/mL) is injected at
Lectures on the Experimental Investigation of the Action of Medicines
Authors: T. L. Brunton
Journal: BMJ (1875)

done myself, in the effort to find such a substance, let me draw your attention to the remarkable fact that no therapeutical agent, no syn- thetical product of the laboratory, no poison, no drug is known which possesses the property of producing fever.The only liquids which have this endowment are liquids which either contain bacteria or have a marked proneness to their production.Further, let me remind you that, whatever effort we may make to discover a disease-producing agent, we must take, both as our starting point and as our guide post, the one fact that we know about it, viz., its pathological action.For our problem is this.In a mixed liquid, we have reason to believe that a body exists which has the property of producing fever.Let us suppose that, by the use of appropriate chenmical methods, we succeed in separating from it a crystalline principle which forms compounds of definite characters and constitution.To us this is of no value, unless it can be shown that the body so obtained contains the fever-producing property.Or let us suppose that a certain organic form is present, and that, by appropriate methods, we can de- termine its botanical characteristics, it is of no interest unless it can be proved that the form encloses the property.It was from forgetting this principle that Hallier, whose indefatigable labours as a botanical investigator of the forms of vegetation which he believed to associate themselves with diseased products were referred to in the last lecture, lost his way.He forgot that, in the investigation of morbific agents, pathological experiment and observation are the only safe guides.His results are valueless, not so much because the botanists say they are wrong botanically, but because he went on developing form out of form, without ascertaining as he went along, by repeated experiments, that the clue he was following was the right one.Let me now return to my own experiments.I will not weary you by detailing the steps by which I was led to adopt my present method, but will content myself with reminding you that the purpose is (assuming that, in all probability, the pyrogenous is separable from what has been called the " phlogogenic" action of the material in question, viz., the septic extract of muscle) to effect this separation by obtaining the " pyrogen" in a convenient form.The plan is as follows.The liquid is first precipitated by absolute alcohol.The precipitate is separated by decantation, again extracted with boiling alcohol, and then filtered.The residue, after having been freed from alcohol by placing it in vaczeo, is extracted with distilled water.The water extract is at once filtered.It is a limpid liquid, which, on injection into the circulation, proves to be pyrogenous.It contains i.2 per cent. of solids.The dose required to produce a characteristic access of fever in a moderate sized dog is five cubic centimetres, that is, three-quarters of a grain of solid matter.
Nephrology: An Annotated Bibliography of Recent Literature
Authors: NEPHROLOGY COMMITTEE
Journal: Annals of Internal Medicine (1983)

ExcerptThis bibliography includes references to 100 recently published journal papers and similar sources that represent important developments in the concept and practice of internal medicine. It has been compiled by the Nephrology Committee as part of the Medical Knowledge Self-Assessment Program VI Syllabus.In preparing this bibliography, the committee reviewed MEDLINEbibliographic printouts of journal articles published since the beginning of 1978 and also drew on sources in libraries of hospitals and other clinical institutions in the United States and Canada; thus, only papers in English are listed, and most are from American journals....
Official Call to the Officers and Members of the American Medical Association to attend the Annual Meeting of the House of Delegates in Chicago, June 23-27, 1991
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolic Engineering
Authors: M. Koffas, C. Roberge, K. Lee, G. Stephanopoulos
Journal: Annual Review of Biomedical Engineering (1999)

▪ Abstract Metabolic engineering is the science that combines systematic analysis of metabolic and other pathways with molecular biological techniques to improve cellular properties by designing and implementing rational genetic modifications. As such, metabolic engineering deals with the measurement of metabolic fluxes and elucidation of their control as determinants of metabolic function and cell physiology. A novel aspect of metabolic engineering is that it departs from the traditional reductionist paradigm of cellular metabolism, taking instead a holistic view. In this sense, metabolic engineering is well suited as a framework for the analysis of genome-wide differential gene expression data, in combination with data on protein content and in vivo metabolic fluxes. The insights of the integrated view of metabolism generated by metabolic engineering will have profound implications in biotechnological applications, as well as in devising rational strategies for target selection for screening candidate drugs or designing gene therapies. In this article we review basic concepts of metabolic engineering and provide examples of applications in the production of primary and secondary metabolites, improving cellular properties, and biomedical engineering.
Malaria at Home and Abroad.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal