tbuckley/cabot-search huggingface dataset:
EXTH-25. A MECHANICALLY-ENGINEERED SPRAY TO INCREASE BRAIN PENETRATION OF CHEMOTHERAPEUTIC NANOPARTICLES IN THE TREATMENT OF HIGH GRADE GLIOMAS
Authors: Phoebe McCrorie, Vincenzo Taresco, Alison Ritchie, Phillip Clarke, David Scurr, Maria Marlow, Ruman Rahman
Journal: Neuro-Oncology (2019)

Abstract Design and implementation of innovative local drug delivery systems (DDS) may overcome current limitations in GBM treatment, such as the lack of therapeutic drug concentrations reaching residual GBM cells following surgery. Here we describe a novel DDS which utilises a bespoke mechanically engineered spray device, designed for safe surgical use, to deliver a mucoadhesive hydrogel containing chemotherapeutic nanoparticles (NPs) into the tumour resection margins. The overall aim is to spray a NP and polymer solution onto the resection cavity and potentially increase penetration of anti-cancer drugs within the 2 cm reoccurrence zone beyond the infiltrative margin. The mucoadhesive gel of choice, pectin, is currently used in other in vivo applications; however we have repurposed this for the brain. Pectin is biocompatible with GBM and human astrocyte cells in vitro and showed neither toxicity nor inflammation for up to 2 weeks upon orthotopic brain injection. Pectin is biodegradable in artificial CSF and is capable of being sprayed from the engineered device. A panel of polymeric, oil-based and polymer-coated NPs have been developed and optimised to maximise drug encapsulation of etoposide and olaparib as proof-of-concept for combination drug delivery. Etoposide/olaparib were chosen due to cytotoxicity from 5 GBM cell lines, including primary lines isolated from the invasive tumour margin (Mean IC50 of 1.1 µM and 8.3 µM respectively). The optimal NP/drug formulation (based on drug encapsulation, spray capability and bio-adhesiveness) will ultimately be assessed for tolerability and efficacy using orthotopic allograft and xenograft high-grade glioma models, including measurement of penetration of drug/nanoparticle in ex vivo murine and porcine brain using novel hybrid time-of-flight/Orbitrap TM secondary ion mass spectrometer (orbiSIMS) technology.
I am an experienced orthopaedic surgeon with no formal recognised training or postgraduate qualifications and I'm in my early fifties. I still find short locums (mostly agency) as a specialist registrar, staff grade, or locum consultant, but I now need to settle down and stop my nomadic existence. Also, I have had about six months of unemployment in the past year owing to a shortage of locum positions. What is your advice for someone in my position? Have I still got a career in medicine in the …
Authors: Sunder Raj Gopaul
Journal: BMJ (2006)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
Uremic Bursitis
Authors: S. PAUL HANDA
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 November 1978Uremic BursitisS. PAUL HANDA, M.D.S. PAUL HANDA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-723_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The description of septic bursitis in the prepatellar and olecranon bursae by Drs. Ho, Tice, and Kaplan in the July issue (Ann Intern Med 89:21-27, 1978) raises a few points that may interest nephrologists caring for uremic patients.Olecranon bursal effusions in uremic patients occur not only from sustained trauma to the olecranon process but also from increased pressure within the bursal vessels resulting from arteriovenous anastomosis and the anticoagulant effects of heparin. The uremic toxins believed to cause inflammation of other serosal surfaces such as pericardium, pleura, and peritoneum with serosanguineous or hemorrhagic effusions (1-3) were...References1. BEAUDRY C, NAKAMOTO S, and KOLFF W: Uremic pericarditis and cardiac tamponade in chronic renal failure. Ann Intern Med 64:990-995, 1966 LinkGoogle Scholar2. SINGH S, MITRA S, and BERMAN L: Ascites in patients on maintenance hemodialysis. Nephron 12:114-120, 1974 CrossrefMedlineGoogle Scholar3. BERGER H, RAMMOHAN G, NEFF M, and BUHAIN W: Uremic pleural effusion. A study in 14 patients on chronic dialysis. Ann Intern Med 82:362-364, 1975 LinkGoogle Scholar4. HANDA S and KHALIQ S: Swelling of olecranon bursa in uremic patients receiving hemodialysis. Can Med Assoc J 118:812-814, 1978 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: S. PAUL HANDA, M.D.Affiliations: West Saint John Community Hospital Saint John, NB E2M 4X3 Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byElectrogenerated Base-Promoted Synthesis of Dithiocarbamate Acid Esters and 3-( N -Substituted-amino)-2-cyanodithiocrotonates from Primary or Secondary Amines and Carbon DisulfideMechanische SchädigungenAcute Complications Associated With HemodialysisKrankheiten der SchleimbeutelAcute Complications Associated with HemodialysisSeptic and Aseptic Olecranon Bursitis in Patients on Maintenance HemodialysisLesions of Bursae, Tendons and Tendon Sheaths 1 November 1978Volume 89, Issue 5_Part_1Page: 723-723KeywordsAnticoagulantsHeparinInflammationPericardiumPeritoneumToxins ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...
Elementos de Física.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SURVIVAL CONTINUES TO INCREASE IN DIFFUSE LARGE B-CELL LYMPHOMA: A POPULATION-BASED ANALYSIS AMONG 25,143 PATIENTS DIAGNOSED IN THE NETHERLANDS BETWEEN 1989 AND 2016
Authors: M. Durmaz, D. E. Issa, O. Visser, N. M. Blijlevens, S. Zweegman, M. J. Kersten, P. J. Lughtenburg, M. E. Chamuleau, A. G. Dinmohamed
Journal: HemaSphere (2019)
EDITORIAL
Authors: Darell D. Bigner
Journal: Neuro-Oncology (2003)

Additional criteria apply.Please refer to protocol 14379-201 for full inclusion and exclusion criteria.† Patients can participate if they had some skin cancers, superficial bladder cancer (cancer that was only on the surface of the lining of the bladder), or carcinoma in situ (cancer that had not spread) of the cervix or breast that had been cured.HIV, human immunodeficiency virus; HBV, hepatitis B virus; HCV, hepatitis C virus; IGF-1R, insulin-like growth factor 1 receptor; KPS, Karnofsky Performance Scale; RT, radiotherapy; SOC, standard of care; TMZ, temozolomide.
HIPPOCRATES, 1966
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amer J of Digestive Diseases, New York
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Merck Buys Maker of HIF2α Inhibitor
Journal: Cancer Discovery (2019)

Merck's acquisition of Peloton Therapeutics gives it access to a novel inhibitor of a protein that enables cancer cells to survive hypoxia. The drug blocks the HIF2α transcription factor and is being tested in a phase I/II trial for clear cell renal cell carcinoma. A phase II trial is testing a related Peloton compound in glioblastoma.
Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines
Authors: Andrew Veitch, Geoffroy Vanbiervliet, Anthony Gershlick, Christian Boustiere, Trevor Baglin, Lesley-Ann Smith, Franco Radaelli, Evelyn Knight, Ian Gralnek, Cesare Hassan, Jean-Marc Dumonceau
Journal: Endoscopy (2016)

The risk of endoscopy in patients on antithrombotics depends on the risks of procedural haemorrhage vs. thrombosis due to discontinuation of therapy. <b>P2Y12 receptor antagonists (clopidogrel, prasugrel, ticagrelor):</b> For low-risk endoscopic procedures we recommend continuing P2Y12 receptor antagonists as single or dual antiplatelet therapy (low quality evidence, strong recommendation);<break/>For high-risk endoscopic procedures in patients at low thrombotic risk, we recommend discontinuing P2Y12 receptor antagonists five days before the procedure (moderate quality evidence, strong recommendation). In patients on dual antiplatelet therapy, we suggest continuing aspirin (low quality evidence, weak recommendation). For high-risk endoscopic procedures in patients at high thrombotic risk, we recommend continuing aspirin and liaising with a cardiologist about the risk/benefit of discontinuation of P2Y12 receptor antagonists (high quality evidence, strong recommendation). <b>Warfarin:</b> The advice for warfarin is fundamentally unchanged from BSG 2008 guidance. <b>Direct Oral Anticoagulants (DOAC): </b>For low-risk endoscopic procedures we suggest omitting the morning dose of DOAC on the day of the procedure (very low quality evidence, weak recommendation). For high-risk endoscopic procedures, we recommend that the last dose of DOAC be taken ≥ 48 hours before the procedure (very low quality evidence, strong recommendation). For patients on dabigatran with CrCl (or estimated glomerular filtration rate, eGFR) of 30 – 50 mL/min we recommend that the last dose of DOAC be taken 72 hours before the procedure (very low quality evidence, strong recommendation). In any patient with rapidly deteriorating renal function a haematologist should be consulted (low quality evidence, strong recommendation).
Era 223-A Phase 3 Trial of Radium-223 Dichloride (Ra-223) in Combination with Abiraterone Acetate (Aa) and prednisone in the treatment of asymptomatic or mildly symptomatic chemotherapynaïve patients with bone-predominant metastatic Castration Resistant Prostate Cancer (Crpc)
Authors: S. Bracarda, G. Procopio, C. Parker, B. Tombal, K. Miller, F. Saad, F. Fang, A. Zhang, M. Kornacker, C. Higano, M.R. Smith
Journal: Annals of Oncology (2015)
INTERNAL AND EXTERNAL ANTISEPSIS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Recommendations for protecting human health against potential adverse effects of long-term exposure to low doses of chemical warfare agents
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PERILS OF THE LABORATORY.
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Natural born killers.
Authors: C W Schmidt
Journal: Environmental Health Perspectives (1998)

This year, 30 million acres of the corn, cotton, and potatoes planted in the United States will have been genetically engineered to produce an endotoxin normally found in the microbe Bacillus thuringiensis (Bt), a self-contained pesticide that will be toxic only to target insects. Transgenic pest-resistant crops are a cost-effective alternative to chemical pesticides, and may offer a way to help feed the world's growing population with minimal environmental impact.
Commentary
Authors: William K. Beatty
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CASE STUDY OF INTERMITTENT CLAUDICATION (LIMPING)
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Commentaire de travail de D. von Renteln et al., pp. 154
Journal: Endoscopy (2009)

See also: Endoscopic closure of the natural orifice transluminal endoscopic surgery (NOTES) access site to the peritoneal cavity by means of transmural resorbable sutures: an animal survival studyEndoscopy 2009; 41(02): 154-159DOI: 10.1055/s-0028-1119465
A Phase 2 Study of Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) in Relapsed or Refractory Indolent Non-Hodgkin’s Lymphoma. A California Cancer Consortium Study.
Authors: Mark Kirschbaum, Leslie Popplewell, Auayporn P. Nademanee, Vinod Pullarkat, Maria Delioukina, Jasmine M. Zain, Deron Matsuoka, Bernadette Pulone, Paul Frankel, Igor Espinoza-Delgado, Stephen J. Forman, David Gandara, Edward Newman
Journal: Blood (2008)
Rewards
Authors: Richard R. Babb
Journal: JAMA (1981)

I considered myself one of the best and brightest. Having just left a prestigious residency and fellowship program, I thought that I was honed to a fine medical edge. My first law of medical practice (more were certain to come) was soon declared:<i>A wheelchair outside the treatment room door means trouble and should be avoided at all cost</i>. Nonetheless, I violated my own law one day, and after taking a deep breath, I stepped over a wheelchair, opened a door, and met John. He was a referral from a colleague, and I was silently furious because John, age 14 years, had cerebral palsy, was painfully deformed, and was extremely ill. He had been abandoned by his parents at an early age, knew few friends, and lived in a foster home. And there he was in my treatment room! John had widespread cancer. During the next year, numerous and prolonged
Robert Roaf
Authors: Roger Croston
Journal: BMJ (2007)

Geoffrey Barker first worked in a neurological team dealing with head injuries from the D-Day landings.In 1948 he joined Tooting Bec Hospital, introducing an opendoor policy in the day hospital and setting up the art therapy department.He specialised in women's mental health and drug abuse, and during 1967-72 was medical administrator.Geoffrey was a tutor at the Tavistock Clinic and held a child guidance fellowship at Guy's Hospital.He was adviser to the Arts Council, chairman of the Dyslexia Teaching Centre, and a founding member of the Alzheimer's Society.On his retirement he continued to work with the Alzheimer's Society, running a carers group from his home for many years, and for MIND, Crossroads, and Carers UK.A Barker
An indolent type of Epstein‐Barr virus‐associated T‐cell‐rich B‐cell lymphoma of the skin: Report of a case
Authors: Hitoshi Take, Kazuo Kubota, Toshio Fukuda, Shogo Shinonome, Osamu Ishikawa, Takuo Shirakura
Journal: American Journal of Hematology (1996)

A 74-year-old Japanese man presented with systemic lymphadenopathy, hepatosplenomegaly, and erythroderma in December 1991.A characteristic pattern of anti-EBV antibodies was suggestive of latent EBV infection.A skin tumor biopsied in April 1993 contained biclonal EBV genomes diffusely in the infiltrate of polyclonal T cells and monoclonal B cells.The clinical course was rather mild in contrast to that of classical EBV-associated disorders.Our case was considered a rare indolent type of EBV-associated T-cell-rich Bcell lymphoma of the skin.