tbuckley/cabot-search huggingface dataset:
Is Calcitriol [1,25(OH)2D3] Harmful to Renal Function?
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver sinusoidal endothelial cell-specific RUNX-1 gene knockdown decreases hepatic inflammation and myeloid cells infiltration in pre-clinical animal models non-alcoholic steatohepatitis
Authors: Dinesh Mani Tripathi, Savneet Kaur, Impreet Kaur, Sumati Rohilla, Abhishak Gupta, Vegi Naidu, Subham Banerjee, Shiv Kumar Sarin
Journal: Journal of Hepatology (2020)
Colon Polyps and Cancer
Authors: O. Kronborg
Journal: Endoscopy (2002)

The superiority of colonoscopy to double-contrast barium enema in detecting neoplasia was finally demonstrated in 2000, but colonoscopic surveillance programs are still based on short-term observations and are mostly inadequate, despite the prospective design of the trials. The evaluation of the diagnostic accuracy of virtual colonoscopy is in progress, but its appropriate place in clinical gastroenterology has not yet been defined. There is now solid evidence that screening with fecal occult blood testing (FOBT) not only reduces the mortality from colorectal cancer, but also that the incidence is substantially reduced after removal of the precursor lesions. Feasibility studies for population screening are ongoing. A once-only sigmoidoscopy will probably not be an optimal method of screening, but may be added to a program with FOBT. Molecular stool screening is attractive, but still experimental. Colonoscopy is not attractive as an initial screening instrument, despite its high diagnostic accuracy, and should only be used for screening high-risk individuals. Genetic methods are playing an increasing role in defining prognostic markers for intestinal neoplasia, and it is recommended that information services should be established for the public. Chemopreventive studies have revealed that dietary fiber supplementation may not reduce the risk of adenomas; the opposite seems to be true for aspirin and non-aspirin NSAIDs, which are active in the early phase of carcinogenesis. New techniques for optimizing diagnostic and therapeutic colonoscopy have been introduced.
HMG CoA Reductase Inhibitors and Quality of Life
Authors: Gerry Oster
Journal: JAMA (1993)

<h3>To the Editor.</h3> —The Air Force Coronary Atherosclerosis Prevention Study (AFCAPS) is an ongoing randomized, double-blind, placebo-controlled primary prevention trial to determine whether treatment with the 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG CoA) reductase inhibitor, lovastatin, will prevent coronary heart disease in persons with mild to moderate elevations of total and low-density lipoprotein cholesterol and low high-density lipoprotein cholesterol levels. A total of 6605 participants without clinical evidence of coronary heart disease are enrolled, including men aged 45 to 73 years and women aged 55 to 73 years. Participants will be followed annually for total coronary heart disease events during a minimum of 5 years. A trial of this size and duration provides an opportunity to evaluate the long-term impact of cholesterol-lowering drug treatment on patient quality of life (QoL). In fact, it may be argued that it is imperative to assess the impact of long-term pharmacologic therapy on QoL in asymptomatic
Infectious Mononucleosis
Authors: James C. Niederman
Journal: JAMA (1968)

In each of 29 patients with infectious mononucleosis (IM) the development of antibodies against a herpes-type virus (EB virus) has been demonstrated by an indirect immunofluorescence test with a virus bearing cell line (EB-3) derived from a Burkitt lymphoma. These antibodies, absent in pre-illness serum specimens, usually appeared early in the disease, rose to peak levels within a few weeks, and remained at relatively high levels during convalescence. They are clearly distinctive from heterophile antibodies and, unlike the latter, they persist for years, probably for life. Tests on sera from 50 randomly selected college freshmen revealed EB virus antibodies in 12, two of whom had positive histories of IM. Of 38 without demonstrable antibodies none had had IM, but the illness developed in three in the next two years. These and other observations strongly indicate that EB virus, or a closely related one, is the etiologic agent of IM.
Self management for men with lower urinary tract symptoms: randomised controlled trial
Journal: BMJ (2007)

Objective To evaluate the effectiveness of self management as a first line intervention for men with lower urinary tract symptoms.Design Randomised controlled trial.Setting A teaching hospital and a district general hospital in London.Participants 140 men (mean age 63 (SD 10.7) years), recruited between January 2003 and April 2004, referred by general practitioners to urological outpatient departments with uncomplicated lower urinary tract symptoms.Interventions Self management and standard care (n = 73) or standard care alone (n = 67).The self management group took part in three small group sessions comprising education, lifestyle advice, and training in problem solving and goal setting skills.Main outcome measures The primary outcome measure was treatment failure measured at 3, 6, and 12 months.Symptom severity (international prostate symptom score; higher scores represent a poorer outcome) was used as a secondary outcome.Results At three months, treatment failure had occurred in 7 (10%) of the self management group and in 27 (42%) of the standard care group (difference = 32%, 95% confidence interval 18% to 46%).Corresponding differences in the frequency of treatment failure were 42% (27% to 57%) at six months and 48% (32% to 64%) at 12 months.At three months, the mean international prostate symptom score was 10.7 in the self management group and 16.4 in the standard care group (difference = 5.7, 3.7 to 7.7).Corresponding differences in score were 6.5 (4.3 to 8.7) at six months and 5.1 (2.7 to 7.6) at 12 months.Conclusions Self management significantly reduced the frequency of treatment failure and reduced urinary symptoms.Because of the large observed benefit of self management, the results of this study support the case for a large multicentre trial to confirm whether self management could be considered as first line treatment for men with lower urinary tract symptoms.Trial registration National Research Register N0263115137; Clinical trials NCT00270309. Methods Patient populationWe recruited men with uncomplicated lower urinary tract symptoms from the outpatient departments of two urological centres in London, a teaching hospital and a district general hospital.We randomised the men either to attend a self management programme in addition to standard care or to standard care alone.During the recruitment period from January 2003 to April 2004, all patients aged over 40 with lower urinary tract
Letter: Management of lithium treatment.
Authors: R P Hullin, S P Tyrer
Journal: BMJ (1975)

were therefore disappointed that no men- ,tion was made of the use of mithramycin in the management of hypercalcaemia in these patients, as the following case illustrates.A 53-year-old woman was admitted to hospital with a nine-month history of bone pain.Bence Jones myeloma was diagnosed on the basis of a
ARGON PLASMA COAGULATION FOR BARRETT’S ESOPHAGUS WITH LOW-GRADE DYSPLASIA: RANDOMIZED TRIAL WITH LONG-TERM FOLLOW-UP EVALUATING THE IMPACT OF POWER SETTING AND PROTON PUMP INHIBITOR DOSE
Authors: E Wronska, M Polkowski, J Orlowska, A Mroz, P Wieszczy, J Regula
Journal: Endoscopy (2020)

Aims Variable results have been reported on the ablation of Barrett`s esophagus (BE) with argon plasma coagulation (APC) and the APC treatment protocol of BE has not been standardized. The aim of this randomized study was to evaluate the impact of power setting and post-ablation proton-pump inhibitor (PPI) dose on the efficacy and safety of APC for BE with low-grade dysplasia (LGD). The long-term outcomes of the treatment were also prospectively evaluated.
Storm Damage
Authors: Donna Doyle
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vinyl Chloride: Inhalation Teratology Study in Mice, Rats and Rabbits
Authors: J. A. John, F. A. Smith, B. A. Schwetz
Journal: Environmental Health Perspectives (1981)

These studies evaluated the effects of inhaled vinyl chloride monomer (VCM) on mouse, rat and rabbit embryonal and fetal development. Groups of pregnant CF-1 mice, Sprague-Dawley rats and New Zealand white rabbits were exposed to 500 ppm VCM for 7 hr daily during the period of major organogenesis. Subsequently, other groups of mice were similarly exposed to 50 ppm VCM, and rats and rabbits were exposed to 2500 ppm. While maternal toxicity was observed, exposure to VCM did not cause significant embryonal or fetal toxicity and was not teratogenic in any of the three species at the concentrations tested. Simultaneous exposure of some of the pregnant animals to VCM by inhalation plus 15% ethanol in the drinking water resulted in toxic effects greater than those associated with exposure to VCM alone in the three species. The fetal effects observed were similar to those reported for these three species following administration of ethanol without VCM exposure.
Survival following bacteremia with resistant organisms
Authors: M. J. Shumate
Journal: JAMA (1996)

<h3>In Reply.</h3> —The resistance of pathogens to antibiotic drugs in our hospital is high. In the group of patients described in our article, 35.4% of<i>S aureus</i>were resistant to methicillin; 30.3% of<i>Enterococcus</i>species were resistant to ampicillin; and 40.9%, 19.9%, and 24.9% of<i>Pseudomonas aeruginosa</i>were resistant to gentamicin sulfate, ceftazidime, and piperacillin sodium, respectively. We must not confuse two possible definitions of appropriate empirical antibiotic treatment. One is a normative definition: Was the treatment in accordance with best practiced hospital protocols? The other definition, used in our article, is a factual one: Was the pathogen sensitive to the antibiotics given? The hypothesis implied in Dr Shumate's letter is that resistant bacteria are more virulent than sensitive ones. To the best of my knowledge, there are no data to support such a hypothesis. In our patients, the mortality of patients with multiresistant pathogens was no greater than in
Fracture of acetabulum with dislocation of hip and sciatic palsy
Authors: O. E. Aufranc
Journal: JAMA (1967)

Dr. David Grainger: The patient is a 39-year-old female, physical education instructor whose automobile was involved in a head-on collision while returning from a weekend of skiing. She was unconscious for approximately three minutes but was oriented when she arrived at the local hospital. Her chief complaints were pain in her right hip, abdomen, and chest. Examination and x-ray films at the local hospital revealed the following injuries: (1) closed fracture of right acetabulum with posterior dislocation of right hip (Fig 1), (2) closed fracture of left fifth metacarpal, (3) fracture of left third rib, (4) laceration of right leg, (5) multiple contusions and abrasions, and (6) possible intraperitoneal injury. A Foley catheter was inserted into the bladder without difficulty, and the specimen obtained was within normal limits. The patient was observed closely for several hours while being given appropriate fluid replacement, and gradual stabilization of her vital signs occurred.
Dural Instrument
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PLOS Biology
Authors: N. Turner
Journal: BMJ (2004)

An open access online journal from the Public Library of Science; first issue October 2003 ISSN 1544 9173 http://www.plosbiology.org/ Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> What an extraordinary time it is in scientific and medical publishing. These pages and many others have documented the increasing tension between traditional publishers and their audience in recent years. The essence of the problem is that readers have become dependent on easy-to-search, universally accessible electronic archives, which are owned by publishers, unlike old printed copies. If institutions stop current subscriptions, they also lose access to old issues. Publishers therefore seem to be free to charge what they like for access—and there is a perception that … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Resistance Fighter
Authors: Povl Riis
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Umbralisib: Treatment for a Rare Lymphoma?
Journal: Cancer Discovery (2019)

The PI3Kδ inhibitor umbralisib may be a promising therapy for patients with relapsed/refractory marginal zone lymphoma: In the phase IIb UNITY-NHL trial, the drug elicited a response rate of 55%. In addition, patients had a 1-year progression-free survival rate of 71%, with manageable side effects.
Highlights
Journal: JAMA Surgery (2013)

As part of efforts to control spending growth, the Centers for Medicare and Medicaid Services and other policy makers are scrutinizing the care provided at Critical Access Hospitals (CAHs).In this context, Gadzinski et al used the Nationwide Inpatient Sample to both characterize surgical care provided at CAHs and compare mortality, length of stay, and costs associated with common inpatient surgeries performed in CAHs vs non-CAHs.For most procedures, no evidence for mortality differences was found.However, despite shorter hospital stays, costs at CAHs were 10% to 30% higher.Although these findings suggest the potential for cost savings, changes in payment policy for CAHs could diminish access to surgical care for rural populations.
A Novel Small Molecule Inhibitor Of Deubiquitylating Enzyme USP14 and UCHL5 Induces Apoptosis In Myeloma Cells and Overcomes Bortezomib Resistance
Authors: Ze Tian, Padraig D'Arcy, Xin Wang, Arghya Ray, Yu-Tzu Tai, Yiguo Hu, Ruben Carrasco, Deepika Das, Paul Richardson, Stig Linder, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood (2013)
In This Issue
Journal: Journal of Clinical Investigation (2010)

Pathway to polycystic kidney diseaseAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by the formation of multiple cysts in the kidneys that can cause chronic renal failure.It is caused by mutations in one of two loci, polycystin 1 (PKD1) and polycystin 2 (PKD2).The precise molecular mechanisms underlying cystogenesis have not been determined, although some data suggest a role for hyperactivation of mammalian target of rapamycin (mTOR).In this issue (3617-3628), Qin and colleagues delineate the pathway responsible for mTOR hyperactivation in a mouse model of ADPKD and demonstrate that this pathway leads to cystogenesis.Initial analysis indicated that mTOR hyperactivation in Pkd1-null mouse cells occurred downstream of the hepatocyte growth factor (HGF) receptor c-Met.Further analysis revealed that Pkd1-null mouse cells expressed increased levels of c-Met because it was not properly ubiquitinated and degraded.This in turn was because the E3-ubiquitin ligase Casitas B-lineage lymphoma (c-Cbl) was sequestered in the Golgi apparatus.As use of a pharmacologic inhibitor of c-Met inhibited mTOR activity and blocked cystogenesis in a mouse model of ADPKD, the authors suggest that blockade of c-Met could provide a new way to treat individuals with ADPKD.
Current Progress in Isolation and Characterization of Toxins Isolated from Pfiesteria piscicida
Authors: Peter D. R. Moeller, Steve L. Morton, Brad A. Mitchell, Scott K. Sivertsen, Elizabeth R. Fairey, Tina M. Mikulski, Howard Glasgow, Nora J. Deamer-Melia, JoAnn M. Burkholder, John S. Ramsdell
Journal: Environmental Health Perspectives (2001)
Erratum: “Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation”
Authors: Rahul Gondalia, Christy L. Avery, Melanie D. Napier, Raúl Méndez-Giráldez, James D. Stewart, Colleen M. Sitlani, Yun Li, Kirk C. Wilhelmsen, Qing Duan, Jeffrey Roach, Kari E. North, Alexander P. Reiner, Zhu-Ming Zhang, Lesley F. Tinker, Jeff D. Yanosky, Duanping Liao, Eric A. Whitsel
Journal: Environmental Health Perspectives (2017)

Gondalia et al. have noted errors in their paper "Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation" in Table 1 andFigure 3. Table 1 should not have included "mean ± SD" labels for columns Sex, n, and P90.EHP regrets the error.In addition, Figure 3 should have had the labels "SHARe Hispanic Women" instead of "SHARe Hispanic Women WHIMS" and "WHIMS White Women" instead of "White Women."The authors regret the error.
Leadership Award for Residents and Fellows
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inflammatory Bowel Disease
Authors: J Schölmerich
Journal: Endoscopy (2003)

Significant advances have been made in our understanding of the etiology of inflammatory bowel diseases, particularly with the identification of the first gene mutation associated with Crohn’s disease; the treatment arsenal has also been expanded, and some new developments have been seen with regard to diagnosis as well. The importance of endoscopic features in relation to the prognosis has been extensively studied. New ultrasound techniques and magnetic resonance-based imaging are on the verge of modifying the diagnostic approach, particularly during follow-up in Crohn’s disease of the small bowel. By contrast, virtual colonoscopy using computed tomography or magnetic resonance imaging does not appear to be of much help. However, the development of these new techniques is continuing rapidly, and an explosion of new information may be expected in the coming years.