tbuckley/cabot-search huggingface dataset:
Abstract 1707: Analysis Of Extracellular Matrix Remodeling On Endomyocardial Biopsies From Patients With Inflammatory Cardiomyopathy
Authors: Olga Lettau, Susanne Rutschow, Sebastian Jaeger, Uwe Kuehl, Kerstin Puhl, Michael Noutsias, Heinz P Schultheiss, Matthias Pauschinger
Journal: Circulation (2007)

Introduction: The biopsy based analyse, with histological, immunohistological and molecular biological analysis of myocardial tissues, represents the only possible tool to investigate the basement of inflammatory cardiomyopathy. Since development of this disease assume involvement of extracellular matrix remodelling, the analyze of this process were aimed in this article. Methods and results: Endomyocardial biopsies from patient with inflammatory cardiomyopathy (n=170) were analysed by RT-PCR, Furthermore, histological, immunohistological and biochemical methods (ELISA) were used to estimate the matrix proteins amount in myocardial tissues (n=36). All results were obtained by comparison of patient groups regarding to left ventricular ejection fraction (LVEF), EF&gt;60 versus EF&lt;30. EF&lt;30 group featured significaly increased inflammation cells per surface area: CD3 (p&lt;0.001), CD11a (p&lt;0.02), CD45 (p&lt;0.02), Mac1 (p&lt;0.02) and HLA (p&lt;0.01). The gene expression revealed an increased transcripts number of IL-2 (p&lt;0.01), IL-5 (p&lt;0.01), IL-6 (p&lt;0.02), INF beta (p&lt;0.039), Collagen type I (p&lt;0.001), III (p&lt;0.0014) and IV (p&lt;0.0004) as well Laminin (p&lt;0.001). On the protein level ICTP (p&lt;0.04), MMP9 (p&lt;0.04) and TIMP I (p&lt;0.01) were significaly increased in this group in comparison with EF&gt;60 group. The escalating number of active CD3 cells correlated positively with BNP (ρ=0.624, p&lt;0.0091), adhesion cell number ICAM (ρ=0.682, p&lt;0.01) and VCAM (ρ=0.475, p&lt;0.01) and with uPA (ρ =0.265, p&lt;0.013), as well as with increased quantity of collagen type III per section area (ρ=0.632, p&lt;0.01). The expanded abundance of type I collagen products was clearly dependent of the expression of collagen I gene (ρ=0.575, p&lt;0.002) and uPA (ρ=0.544, p&lt;0.004). Precise correlation between the amount of MMP 9 protein and downward EV values (ρ=− 0.4133, p&lt;0.0073) was also observed in the patient group with EF&lt;30. Conclusion: Myocardial inflammation lead to an imbalance in the MMP/TIMP system with development of myocardial fibrosis with significant correlation to LV-dysfunction. Extracellular matrix remodeling with an imbalance in the MMP/TIMP system plays an important role in the development of left ventricular dysfunction in inflammatory heart disease
Contents, Vol. 34, No. 2-3, 1980
Authors: J. Eyer, S.V. Kasl, S. Cobb, F. Kittel, M. Kornitzer, M. Dramaix, N. van Dijkhuizen, H. Reiche, T. Theorell, L.J.P van Doornen, David Jenkins, Stephen J. Zyzanski, F. Verhagen, C. Nass, A. Appels, A. van Bastelaer, J. Winnubst, A. Appels, H. van Dijl, N. Nagelkerke
Journal: Psychotherapy and Psychosomatics (1980)
Combined Effects of As4S4 and Imatinib on Chronic Myeloid Leukemia Cells and BCR-ABL Oncoprotein.
Authors: Tong Yin, Ying-Li Wu, Hui-Ping Sun, Guan-Lin Sun, Ji Zhang, Guo-Qiang Chen, Sai-Juan Chen, Zhu Chen
Journal: Blood (2004)
Synergism in Carcinogenesis: Reply
Journal: JNCI Journal of the National Cancer Institute (1985)

Synergism in Carcinogenesis: Reply JNCI: Journal of the National Cancer Institute, Volume 74, Issue 3, March 1985, Pages 730–731, https://doi.org/10.1093/jnci/74.3.730 Published: 01 March 1985
Re: Efficacy of influenza vaccine
Authors: C. Harper
Journal: JAMA (1985)

<h3>In Reply.—</h3> I would like to point out that I did not suggest the reinstitution of a foreign quarantine service. I believe I simply raised the possibility as one of the considerations in trying to decrease importations of measles, and I rejected it out of hand as unlikely to be cost-beneficial. Mr George's suggestion that perhaps the best approach would be global eradication of measles merits further scrutiny. It is not obvious to me that this would necessarily be cost-effective for underdeveloped countries. Given very limited resources, which of the many things that could be done to improve the health and welfare of the population of those countries ought to be done first? How many of the 2.6 million children estimated to have died of measles worldwide in 1984 would have died in childhood of other causes had measles been eradicated? On the other hand, might it not be cost-beneficial
Quantitative Aspects in the Assessment of Liver Injury
Authors: Gabriel L. Plaa
Journal: Environmental Health Perspectives (1976)

Liver function data are usually difficult to use in their original form when one wishes to compare the hepatotoxic properties of several chemical substances. However, procedures are available for the conversion of liver function data into quantal responses. These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency. These same procedures can be utilized for estimating the relative hazard involved if one compares the liver-damaging potency to the median effective dose for some other pharmacologie parameter. Alterations in hepatic triglycerides, lipid peroxidation, and the activities of various hepatic enzymes can also be quantitiated in a dose-related manner. This permits the selection of equitoxic doses required for certain comparative studies and the selection of doses in chemical interaction studies. The quantitative problems involved in low-frequency adverse reactions and the difficulty these present in the detection of liver injury in laboratory animals are discussed.
A cohort compassionate-use program with cabazitaxel plus prednisone for patients with metastatic castration-resistant prostate cancer: Interim results.
Authors: Sevil E. Bavbek, Zafar Malik, Giuseppe Di Lorenzo, Hans-Jorg Scholz, Inge M van Oort, Siobhan Ng, Mustafa Ozguroglu, Winald R. Gerritsen, Stefan Mueller, Timo Marttila, Luis M. Anton-Aparicio, Peter Albers, Juergen Gschwend, Samira Bensfia, Evelyne B Ecstein-Fraïssé, Sergio Bracarda, Axel Heidenreich
Journal: Journal of Clinical Oncology (2012)

172 Background: In the Phase III TROPIC trial ( NCT00417079 ), cabazitaxel/prednisone (CbzP) improved overall survival compared with mitoxantrone/prednisone in patients (pts) with mCRPC who had progressed on or after prior docetaxel (D) (HR 0.70; P &lt; 0.0001). The survival benefit observed supported the establishment of 2 programs (based on local regulations): a compassionate use (CUP) and an early access program (EAP) ( NCT01254279 ). Methods: The aims of both programs are to provide drug to pts with mCRPC who may benefit from CbzP prior to commercial availability, and further evaluate CbzP safety profile. Total enrollment for both programs is targeted to be 1,600 pts from 250 centers in Europe, Asia, Latin America and Canada. Eligible pts will receive CbzP (25 mg/m 2 Q3W plus oral prednisone 10 mg daily) until disease progression, death, unacceptable toxicity or physician/pt decision. Results: Baseline characteristics and safety data are available for the first 399 pts. Median age was 68 yrs (range 43–89); 90.2% were ECOG PS 0–1. Median cumulative dose of prior D was 675 mg/m 2 (median 9 cycles). For pts whose disease progressed following D, the median time from last dose of D to progression was 4 months; 53.3% of pts experienced disease progression either during or &lt; 3 months after D. 61% of pts had ≥ 2 metastatic sites; the most common were bone (93.2%) and regional lymph nodes (34.4%). A median of 4 cycles of CbzP was administered and 4 pts received ≥ 10 cycles. Median relative dose intensity was 99.2% (range 80.1–104.9). G-CSF was administered to 34.3% of pts in Cycle 1 (6.3% therapeutic, 26.6% prophylactic). Overall, 71.4% of pts experienced adverse events (AEs) (all grades) considered related to study drug. The most common Grade 3–4 AEs included neutropenia 11.3%, febrile neutropenia 6.3%, anemia 2.8%, fatigue 2%, neutropenic sepsis 1.8%, vomiting 1.3% and diarrhea 1%. 8 (2%) treatment-related deaths were reported. Conclusions: The CUP/EAP programs provide additional safety data for CbzP in a routine clinical practice population of pts with mCRPC. Treatment with CbzP was tolerable, with a manageable toxicity profile consistent with the data reported for the TROPIC trial.
"THE TREATMENT OF CANCER BY ITS OWN TOXINS."
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Milk Question.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sunday Rounds
Authors: John L. Wright
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TIDAL IRRIGATION OF WOUNDS BY MEANS OF LIQUID-TIGHT CLOSURE
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Controlled Evaluation of Primidone and Diphenylhydantoin Sodium
Authors: J. Gordon Millichap
Journal: JAMA (1968)

Primidone and diphenylhydantoin sodium were compared in a controlled study of children with major varieties of epilepsy. Records of seizures were adequate in 24 patients, and side effects were evaluated in 37. Seizures were controlled in six of 12 patients treated with primidone and four of 12 who received diphenylhydantoin. Primidone and diphenylhydantoin caused side effects in three of 20 patients, and in six of 17 patients, respectively. The drugs were found to differ only in the nature of their side effects.
Infectious mononucleosis and malignant lymphoproliferative diseases
Authors: D. A. Stevens
Journal: JAMA (1972)

The relationship of infectious mononucleosis (IM), a benign lymphoproliferative disease, to malignant lymphoproliferative disease has been a subject of great interest almost since the definition of IM as a distinct clinical and pathological syndrome 50 years ago. This interest has been heightened recently by evidence suggesting that a new herpesvirus (EB virus) may be the etiologic agent, long suspected to be a virus, in IM.<sup>1</sup>(See QUESTION AND ANSWER, p 917.) Recent clinical and pathological observations and immunological studies have caused us to reexamine the possible relationship of IM to malignant diseases. Seroepidemiologic studies with the EB virus have also led to speculation that this agent, perhaps in concert with another factor such as chronic malaria, may also be the etiologic agent in Burkitt's lymphoma. This eponym describes a clinicopathological entity initially noted to occur with high incidence in African children, but which has subsequently been described in many
Errata
Authors: Max Velmans
Journal: Behavioral and Brain Sciences (1992)

On p. 662 of the target article “Is Human Information Processing Conscious,” by Max Velmans, BBS (1991), 14(4):651–69, the phrase “electrical stimuli applied 500 msec later” (sect. 5.1, para. 3, 2nd sentence) should read “electrical stimuli applied 500 msec earlier .”
Carcinogenicity of By-Products of Disinfection in Mouse and Rat Liver
Authors: Sydna L. Herren-Freund, Michael A. Pereira
Journal: Environmental Health Perspectives (1986)

By-products of disinfection were tested for initiating and/or promoting activity in rat liver by using the rat liver foci bioassay. The assay uses an increased incidence of gamma-glutamyltranspeptidase-positive foci (GGT foci) as an indicator of carcinogenicity. The by-products of disinfection, including chloramine, halogenated humic acids, halogenated ethanes, halogenated acetonitriles, halogenated methanes, halogenated ethylenes, and N-Cl-piperidine, did not initiate GGT foci, which would indicate that they are not capable of initiating carcinogenesis. Chloroform and halogenated benzenes were tested in this assay for their ability to promote the occurrence of GGT foci and tumors initiated by diethylnitrosamine (DENA). Chloroform (1800 ppm in the drinking water) either had no effect or inhibited the occurrence of GGT foci when administered subsequent to a single dose of DENA. However, when the chloroform was administered in drinking water concurrently with weekly doses of DENA, it enhanced the formation of liver tumors. Of 20 halogenated benzenes tested, only 1,2,4,5-tetrachlorobenzene and hexachlorobenzene promoted the occurrence of DENA-initiated GGT foci. Thus in rat liver, the tested by-products of drinking water disinfection did not demonstrate tumor-initiating activity, although a few appeared to possess tumor-promoting activity. Chloroform was also tested for tumor-promoting activity in 15-day-old Swiss mice initiated with ethylnitrosourea (ENU). At weaning they started to receive either 1800 ppm chloroform or 500 ppm sodium phenobarbital (the positive control for tumor promotion) in their drinking water. The mice continued to receive either chloroform or phenobarbital until 51 weeks of age and were sacrificed at 52 weeks of age.(ABSTRACT TRUNCATED AT 250 WORDS)
International Clinics. A Quarterly of Illustrated Lectures and Especially Prepared Original Articles on Treatment, Medicine, Surgery, Neurology, Pediatrics, Obstetrics, Gynecology, Orthopedics, Pathology, Dermatology, Ophthalmology, Otology, Rhinology, Laryngology, Hygiene, and Other Topics of Interest to Students and Practitioners.
Journal: Annals of Internal Medicine (1928)
Health Agencies Update
Authors: Joan Stephenson
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leucotomy
Authors: H. E. W. Hardenberg
Journal: BMJ (1956)

<h3>Objectives</h3> The present study investigated the prevalence and factors contributing to dental caries in 12–15-year-old adolescents in northeast China to provide information for dental caries promotion programmes. <h3>Design, setting and participants</h3> A cross-sectional survey including caries examination and questionnaire was performed in Liaoning province, China. 3731 12–15-year-old school adolescents participated in the survey. School adolescents were randomly selected and received a clinical oral examination and completed questionnaires that assessed their oral health-related behaviours and attitudes. <h3>Results</h3> Overall, 3731 12–15-year-old school adolescents participated in the survey. The prevalence of dental caries in these adolescents was 53.65%, and the mean number of decayed–missing–filled teeth (DMFT) in the adolescents was 1.64±2.38 in northeast China, which was higher than the mean in China as a whole. A remarkable difference in DMFTwas exhibited between age groups, region and gender (p&lt;0.05). Logistic regression analysis showed that age, region, gender and father’ education were related to the occurrence of caries in these adolescents. <h3>Conclusion</h3> The 12–15-year-old school adolescents assessed exhibited a high prevalence of dental caries and low awareness of oral health. It is critical to protect permanent teeth, and oral and dental health education and promotion should be more comprehensively integrated into school courses for these adolescents.
Clinical characteristics and outcomes of advanced cancer patients referred to outpatient supportive care who missed their appointment.
Authors: Marvin Omar Delgado-Guay, Silvia Tanzi, Maria Teresa San Miguel Arregui, Gary B. Chisholm, Janet L. Williams, Julio Allo, Eduardo Bruera
Journal: Journal of Clinical Oncology (2013)

79 Background: Supportive Care Outpatient Clinics (SCOC) offer comprehensive care and symptom management to patients with advanced cancer (AdCa). Missed appointments (MA) are important source of problems to patient care and clinic operations. But there are no studies on the clinical outcomes of patients who fail to show for consultation. Methods: We determined the frequency of MA, including clinical and demographic data, and reviewed clinic appointment records for 218 consecutive kept (KA) and 218 MA for distinct patients referred to SCOC from January to December 2011. Results: 218/1,352(16%) AdCa who were referred to our SCOC, missed their appointment. Median age was 57 years (interquartile range 49-67). The mean(range) time between referral and appointment was 7.4 days(0-71) for KA vs. 9.1 days(0-89) for MA (p=0.0062). Age, gender, marital status, and cancer types or stages, and reasons for referral to SCOC were not significantly different between MA and KA patients. The reasons for MA were: admission to the hospital 17/218(8%), death 4/218(2%), appointment with primary oncologist 37/218(18%), other appointments 19/218(9%), visits to emergency room(ER) 9/218(9%), and unknown 111/218(54%). MA patients visited more the ER at 2 weeks 16/214(7%) vs. 5/217(2%), p=0.01, and 4 weeks 17/205(8%) vs. 8/217(4%), p=0.06. Median survival for MA patients was 177 days (range:127-215) vs. 253 days (range:192-347) for KA patients (p=0.013). Multivariate analysis showed that MA were associated to the time between referral and scheduled appointment (OR: 1.026/day, p=0.03), referral from targeted therapy services (OR:2.177, p=0.004), living at Texas/Louisiana regions (OR;2.345, p=0.002), having advanced directives (OR:0.154, P&lt;0.0001), and being referred for symptom control(OR:0.024, p=0.0003). Conclusions: AdCa with MA have worse survival and increased ER utilization. We identified AdCa at higher risk for MA who should undergo more aggressive follow up. More research on MA prevention is needed.