tbuckley/cabot-search huggingface dataset:
Rubella vaccination of hospital employees
Authors: S. R. Preblud
Journal: JAMA (1981)

Before rubella vaccine was introduced in the United States in 1969, rubella was primarily a disease of elementary school-aged children.<sup>1</sup>However, outbreaks have also occurred in adolescent and young adult populations (eg, military recruits<sup>2</sup>) because 15% to 20% of persons in these age groups were susceptible.<sup>1,3</sup>Widespread vaccination of young children has successfully interrupted the characteristic six- to nine-year rubella epidemic cycle, reduced overall reported endemic rubella activity by 70%, and decreased the number of reported cases in children younger than 15 years by 85%.<sup>1</sup> On the other hand, the risk of rubella among adolescents and young adults, who now account for most reported cases, has declined less dramatically, as evidenced by their unchanged susceptibility rate<sup>1,4</sup>and by outbreaks in secondary schools,<sup>5</sup>colleges,<sup>5-7</sup>and military bases.<sup>3,8</sup>Because hospital employees are likely to be as susceptible as the general public,<sup>9-14</sup>outbreaks in
Monkey Psychiatrists
Authors: STEPHEN J. SUOMI, HARRY F. HARLOW, WILLIAM T. McKINNEY
Journal: American Journal of Psychiatry (1972)

Most efforts that have been made to reverse the effects of isolation on monkeys have been unsuccessful. The authors report on successful rehabilitation through the use of "therapist" monkeys. The therapists, three months younger than the isolate monkeys, initiated social contact in a nonthreatening manner. Within six months, the isolates' disturbance behaviors had nearly disappeared and they displayed normal age-appropriate social and play behaviors.
NO FEAR OF CHOLERA.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IRON IN RELATION TO ANEMIA AND OTHER DISORDERS
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperthyroidism
Authors: Glenn Matfin
Journal: Annals of Internal Medicine (1995)

Letters1 March 1995HyperthyroidismGlenn MatfinGlenn MatfinSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-5-199503010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The review by Klein and colleagues [1] on the treatment of hyperthyroid disease was comprehensive and well balanced. However, several important issues were not fully covered. I concur that propylthiouracil is the preferred therapy in pregnant women, not only because of the low or nonexistent risk for teratogenicity but also because of the rare abnormality of aplasia cutis congenita that may be associated with the use of methimazole in pregnancy.Two distinct antithyroid drug regimens are available. In the first, the dose of drug is titrated to keep the patient euthyroid; in the second, a fixed drug ...References1. Klein I, Becker DV, Levey GS. Treatment of hyperthyroid disease. Ann Intern Med. 1994; 121:281-8. Google Scholar2. Weetman AP, Pickerill AP, Watson P, Chatterjee VK, Edwards OM. Treatment of Graves' disease with the block-replace regimen of antithyroid drugs: the effect of treatment duration and immunogenetic susceptibility on relapse. Q J Med. 1994; 87:337-41. Google Scholar3. Chanson P, Weintraub BD, Harris AG. Octreotide therapy for thyroid-stimulating-hormone-secreting pituitary adenomas. Ann Intern Med. 1993; 119:236-40. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1995Volume 122, Issue 5Page: 393-394KeywordsDrugsHypothyroidismImmunosuppressivesPituitary tumorsPregnancySomatostatinSurgeryThyroidThyroid hormonesThyroxine Issue Published: 1 March 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Safety in flying.
Journal: BMJ (1973)

oestrogens in low doses, or orchidectomy, appears still to be the best treatment.7According to a recent report by a re- search group the average patient with prostatic cancer derives no benefit from immediate treatment with sitil- boestrol or by orchidectomy unless the cancer is causing serious symptoms.7The excess mortality associated with oestrogen therapy, even when the dose is restricted to 5 mg daily by mouth, shows that this treatment should be given only to patients whose growth is causing serious clinical symptoms.There appears to be no point in combining oestogen therapy with orchidectomy.Adrenalectomy offers no clinical improvement, and hypophysectomy, though practised in some centres, is not generally recommended by this reserch group.Perhaps one of the most heartening reports was that from the radiotherapists, who were able to show that in certain hands radiotherapy can produce survival rates at 5 and 10 years comparable with other methods of treatment.8In very advanced cases some benefit may be derived from chemotherapy, particularly with aniline mustard.It was suggested that those tumours respond best which produce f- glucuronidase, and this may form the basis of a predictive test.This agent is known to circulate in the body as a glucuronide, and it is assumed its activation will occur preferentially in tissue with a high 8-glucuronidase activity.
<i>Sajous' Annual,</i>1896. Annual of the<i>Universal Medical Sciences and Analytical Index.</i>A yearly report of the progress of the general sanitary sciences throughout the world. Edited by Charles E. Sajous, M. D., Paris, and seventy associated editors. Issue of 1896. F. A. Davis Company, Philadelphia; Chicago, L. D. Pierce
Journal: American Journal of Psychiatry (1897)
Discussion, ideas abound in migraine research; consensus remains elusive
Authors: T. Kirn
Journal: JAMA (1987)

WHEN LEONARD LOVSHIN, MD, asked a fellow conferee at the 28th Annual Scientific Meeting of the American Association for the Study of Headache to support a point he was making about migraine, his friend quipped: "That's twice in 30 years we've agreed." The friend may have been only half joking. And Lovshin, director emeritus of the Department of Internal Medicine at the Cleveland Clinic Foundation, was lucky at that. Had he asked anyone else, that person very well might have disagreed. When it comes to migraine, there never has been much consensus among headache specialists. But recent research suggests that migraine, and headache in general, is even more of a mystery than had been thought, and many headache specialists are beginning to question even the basic tenets of migraine theory. In fact, disagreement over the whats, whys, and hows of migraine are so common that Donald Dalessio, MD, chair of
The pharmacology of disordered sleep. A laboratory approach
Authors: W. W. Zung
Journal: JAMA (1970)

This presentation is a synthesis based upon knowledge and hypotheses from several areas of science in an attempt to further relate drug action and sleep disturbance. It is hoped that this approach may lead us to a rational basis for the treatment of various states of disordered sleep. <h3>What Sleep Disturbances Are Present in Clinical Disorders?</h3> Insomnia is a symptomatic complaint and its presence, type, and severity can only be determined individually by actual laboratory all-night studies. The main finding associated with anxiety states clinically and in the laboratory is the difficulty in falling asleep. A review of the sleep of schizophrenics indicated that sleep problems are minimal in this disorder. This is in contrast with depressive disorders in which sleep disturbance is a cardinal symptom of the illness. The results of Fig 1 are based upon data obtained from laboratory studies using all-night electroencephalographic and electro-oculographic recordings of sleeping
Costs of HIV/AIDS Rise, Care Disparities Increase
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Weighing Alternatives
Authors: Jan P. Vandenbroucke
Journal: JAMA (1988)

<h3>To the Editor.</h3> —The recent article by Drs Browner and Newman<sup>1</sup>about the civil rights of<i>P</i>values is a useful and imaginative description of an important thought process in medical scientific inference. It is to be hoped that the article will achieve a wide readership. One aspect of the present publication is puzzling, however, to a person with an interest in the historical development of ideas in epidemiology and biostatistics. The puzzling aspect is the apparent need for the publication. Indeed, the essence of the argument was already known and was taught to physicians more than a half century ago. To substantiate this claim, we quote almost a full paragraph from the 1930s book entitled<i>An Introduction to Medical Statistics</i>by Woods and Russell,<sup>2</sup>which was intended as a textbook for physicians who took graduate courses at the London School of Hygiene as organized by Professor M.
Oregon pioneers "more ethical" Medicaid coverage with priority-setting project
Authors: M. F. Goldsmith
Journal: JAMA (1989)

ETHICS AND LEGISLATORS often figure in the news, usually because the latter have abused the former. But in two western states, elected officials attempting to solve the tough problem of guaranteed access to medical care are coming to grips with ethics in its root meaning: moral duty and obligation. Enthusiastically supported by the Oregon Medical Association, the state has enacted legislation aimed at using Oregon's health care resources more justly. It will provide services considered basic for a greater number of people on Medicaid while curtailing payment for other types of service deemed less necessary or of benefit to only a few. This type of arrangement has been denoted "rationing," and been piously denounced by policymakers who say, "Any legislation concerning who gets what service is a terrible idea. It means health care rationing will be aimed at poor people, and that's not fair." But what really isn't fair, says
Urinary metabolomics of gastric cancer.
Authors: Angela Weiyee Chan, Pascal Mercier, Dan E. Schiller, Dean Eurich, David Broadhurst, Michael B. Sawyer
Journal: Journal of Clinical Oncology (2015)

e22253 Background: Gastric adenocarcinoma (GC) has a 70-75% mortality. There is no standard screening in North America. Metabolomics is a systems biology approach to measure low molecular weight chemicals (metabolites) in body fluids/tissues to provide a phenotypic “fingerprint” of disease. In this study it was hypothesized that metabolomic profiling of urine samples using 1H-NMR spectroscopy could discriminate between resectable GC, benign gastric disease (BN), and healthy (HE) patients (pts). Methods: Midstream urine samples were collected, processed, and biobanked at -80°C, from 40 BN, 40 HE and 43 GC pts (matched on age, gender and BMI). Samples were randomized into 2 groups: one to discover biomarkers of GC, the other to validate initial findings. In the discovery experiment 30 BN, 30 HE, and 29 GC pts’ urine were analyzed using high-resolution 1H-NMR spectroscopy under a validated standard operating procedure. Resulting spectral traces were converted into annotated and quantified metabolite profiles of 58 metabolites. Univariate statistics and Partial Least Squares Discriminant Analysis (PLS-DA) developed a GC vs. HE discriminative model. A Receiver Operator Characteristic (ROC) curve was constructed. 10 BN, 10 HE and 13 GC pts were analyzed in a separate external validation experiment under the same procedure. Results: In the discovery experiment, there was no significant difference in metabolite profiles between GC and BN pts. Univariate analysis revealed 13 metabolites that differed significantly between GC and HE (p < 0.05). Correlation analysis and PLS-DA produced a discriminative model with an area under ROC curve of 0.996, such that for a specificity of 100% the corresponding sensitivity was 93%. The external validation set confirmed the significance of 4 of 13 metabolites that were discriminative in the discovery experiment: N-acetylglutamine derivative, Alanine, 2-hydroxyisobutyrate, and Pantothenate (p < 0.05). Conclusions: GC pts have a distinct urinary metabolite profile compared to HE controls; however in this study metabolomic profiling was unable to discriminate GC from BN pts. This was probably due to sample size and phenotypic heterogeneity of BN pts. This preliminary study shows clinical potential for metabolic profiling for early GC detection.
Encephalopathy following jejunoileostomy
Authors: A. J. Finestone
Journal: JAMA (1982)

<h3>To the Editor.—</h3> We empathize with T. Cameron MacCaughelty, MD, in his article "An Anesthesiologist's Plea" (1981;246:2692). However, we came to the conclusion years ago that we could not legislate respectability regardless of how hard we or our national organization tried. Regardless of the situation, we have found it the same. Even though we have suggested or have made interventions that have shown both our expertise and our interest in the individual patient's problems and care and have demonstrated by that intervention an improvement in care, we have found later only to be considered a "hand-maiden" to the other physicians involved with the patient. Yes, Dr MacCaughelty, we do have much to offer our patients and do look forward to improved rapport with our physician colleagues, but like you, we have not found the answer despite our continued presence in both the operating room and intensive care areas.
Exploding Bottles
Authors: I. Brian Taylor
Journal: JAMA (1963)

<h3>To the Editor:</h3> —In the Dec 1 issue ofThe Journal(<b>182:</b>9) there appeared a letter by Moyes and Andrews pointing out the dangers of exploding bottles. I recently had occasion to treat an 80-yr-old female whose left eye was penetrated by an exploding bottle of carbonated beverage. The result was loss of vision in that eye. The explosion occurred on a summer day when the temperature was about 95 F, which is the average in this part of the world for many weeks. I agree wholeheartedly with the authors that the carbonated beverage bottle is a dangerous weapon and that explosions are not unique to the tropics. I send in this report toThe Journalin hope that it may occasion reports from other physicians regarding exploding bottles and that the public may be made aware of such dangers.
George Bray: the nutrition message must be spread
Authors: J. Elliott
Journal: JAMA (1979)

The politics of nutrition and obesity, concerns that have grown to spectacular prominence in the last few years, are the new charges of George A. Bray, MD, obesity researcher and professor of medicine at the University of California, Los Angeles, School of Medicine. Recently appointed nutrition coordinator for the Department of Health, Education, and Welfare (DHEW), Bray has undertaken to teach the American public how to make prudent dietary choices—a task not only difficult but perhaps impossible in the face of an underfunded research effort in the area of nutrition as well as waning public concern for the serious health consequences of obesity. "Although nutritional concern seems to have become more prominent in the last 15 years," Bray told<i>JAMA</i>MEDICAL NEWS, "public interest has not truly grown. As a result the average American today is heavier than a person of the same height was ten years ago." Data from
Epidemiologic Considerations
Authors: A. D. Langmuir
Journal: JAMA (1961)

FIVE AND ONE-HALF YEARS AGO, when the Salk vaccine first became available, some epidemiologists, including myself, were hopeful that poliomyelitis could rapidly be eradicated. Since then, its incidence has declined, largely because of the use of this vaccine. But, poliomyelitis seems far from being eradicated. The dreamed-of goal has not been achieved. In fact, many students of the problem question that eradication of poliomyelitis infection with inactivated vaccine is a scientifically tenable concept. Soon, a basically new type of poliovirus immunization—the orally administered live virus vaccine— will enter the picture. Dr. Albert Sabin, one of the developers of oral vaccine, is now calling for eradication of poliomyelitis, arguing that the oral vaccine makes this scientifically possible. It is pertinent, therefore, at this symposium, to review the experience of the past 5 1/2 years, from both the practical and scientific points of view. It may be worthwhile to examine the reason
Very-low-density lipoprotein in search of precision
Authors: S. Vaisrub
Journal: JAMA (1979)

Some words are inherently vague. Take "very," for instance. "The use of `very' as an expression of quantity or measurement does not increase precision," writes Roland in "Very,<i>Very</i>Imprecise."<sup>1</sup>Yet, ironically, imprecise as it is, "very" found its way into scientific terminology. It insinuated itself into the classification of lipoproteins. "Very low-density lipoprotein" (VLDL) is an accepted term. "Very" sets apart the triglyceriderich (pre-β) lipoproteins, from the cholesterol-rich, low-density (β) lipoproteins (LDLs). The relationship of VLDL to LDL is thought to be that of precursor to product.<sup>2</sup>There is impressive evidence that most VLDLs are converted to LDL through loss of glycerides and apoproteins. A notable exception is apolipoprotein B (apo-B), which remains largely unchanged. Radiolabeled apo-B can thus serve as a continuous guiding thread through the labyrinth of VLDL to LDL conversions, providing a new approach to the study of VLDL kinetics. It was hoped that
Disadvantages of Tantalum Prosthesis in Repair of Hernias and Laparoceles
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Speech cluttering
Authors: D. A. Daly
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal