tbuckley/cabot-search huggingface dataset:
Compression fracture of L-2 with cauda equina injury
Authors: O. E. Aufranc
Journal: JAMA (1968)

Dr. Patrick J. Logue: This was the first Massachusetts General Hospital admission for this 36-year-old Negro laborer who was admitted shortly after noon with a history of a fall of 12 feet. While eating his lunch on scaffolding at a construction site near the hospital, the structure collapsed. He described unconsciousness, lasting "a few minutes" and back pain without radiation to the legs. On admission to the Emergency Ward he was fully alert and complaining of severe pain in the low back. The mental status was clear, and the patient was oriented to time and place. Cranial nerve function was normal. There was hypalgesia to pinprick over dermatomes L-3 to S-2 in the right lower extremity. Position and vibratory senses were intact. Detailed muscle examination was not performed because of the patient's pain, but flexion and extension of toes, ankles, and knees were described as present bilaterally. Deep tendon reflexes
Leading cases
Authors: B. Nortell
Journal: JAMA (1976)

EVERY week there are many court decisions that have an impact on the practice of medicine. These decisions are currently reported, in summary, in<i>The Citation</i>, a newsletter published twice a month by the Office of the General Counsel, American Medical Association. Some of these decisions are of such special importance that they deserve the wider publicity that can be obtained through the pages ofThe Journal. Trial court decisions, which are of little precedent value and are subject to reversal, are omitted. Selected decisions are usually restricted to those of the highest state or federal court. It should be remembered, however, that a decision by a court in one state is not necessarily binding elsewhere. <h3>The National Standard of Care</h3> The degree of skill or care that is legally required of a physician in Wisconsin is no longer limited to that exercised by physicians in the same or similar
Abstract 19324: Effects of Simulated Microgravity on Ckit+ Cardiac Progenitor Cells
Authors: Konstantinos E Hatzistergos, Lauro M Takeuchi, Wayne Balkan, Joshua M Hare
Journal: Circulation (2015)

Introduction: Space flight has profound negative impacts on cardiac health. Whereas microgravity appears to benefit cardiomyogenesis, long-duration space flight results in increased risk for cardiomyopathy. Here, we focused on cKit+ cardiac progenitor cells (CPCs) to elucidate the effects of microgravity in the heart. Hypothesis: Microgravity inhibits migration, proliferation and differentiation of CPCs. Methods: Adult heart tissue or induced pluripotent stem cells (iPSCs) from cKitCreErt2;IRG mice were grown for up to 24- (n=5) or 21-days (n=6), respectively, in static (SC) or a rotary cell-culture system (RCCS, simulated microgravity) in the presence of 4-OH tamoxifen to irreversibly label CPCs with EGFP. Expression of EGFP was quantified at selected time points in heart explants and iPSC-derived beating embryoid bodies (EBs). In addition, microarray analysis was performed on EBs at selected time points (n=11). Results: We found that, although explants in SC consistently produced EGFP+ CPCs with full capacity to proliferate and migrate, expression of EGFP was abolished in RCCS (p&lt;0.05). Similarly, when day-4 EBs (formed via the hanging-drop method) were transferred to RCCS, they generated significantly fewer spontaneously beating EBs compared to EBs grown in SC (p=0.0005), whereas expression of EGFP in beating EBs was downregulated ~10-fold (p=0.01). Microarray analysis of EBs illustrated that the effect of CPs was accompanied by downregulation of genes related to migration, differentiation and development of the cardiac neural crest cell (CNC) lineage (i.e. Pax3, semaphorins, endothelin) without affecting the expression of cardiac mesoderm-related genes (i.e. GATA4, NKX2-5, MEF2C). Intriguingly, the effect of RCCS in CNC-related genes could be partly rescued upon transfer of EBs from RCCS to SC. Conclusions: cKit expression and CNC pathways are inhibited under simulated microgravity but can be reversed by returning to normal gravity. Our findings provide novel insights into the role of gravity in cardiomyogenesis and suggest that CPCs should be targeted therapeutically for the prevention and treatment of microgravity-induced cardiomyopathy.
What is "serum albumin"?
Journal: BMJ (1986)

ever, urine osmolality depends-not only on secretion of antidiuretic hormone but also on the kidney's ability to respond.If the kidney's concentratmg ability haa been lost the urine will.bedilute irrespective of the level ofantidiuretic hormone, so the finding ofa dilute urne in this situation does not by itself permit any conclusion to be drawn about antidiuretic hormone secretion.Furthermore, if the kidney is insensitive.toantidiuretic hormone urine osmoLality conveys .noinformation on the setting of the osmostat, which can be assessed only by direct assay of antidiuretic hormoneas a function of serum osmolality Totally implantable vascular access for long.term chemotherapy Dr M F-McMULUN (Royal Victoria Hospital,eat BTl2 6BA) writes: Following the comments of MrA E Youngandcolleagues (7 tecember,-p 1608) I would like to draw attention to another advantage of.thePort-a-Cath.In this unit two patients have used the Hickdman -catheter as a means of attempted suicide, Both patients, young men, had Hickman catheters inserted for intensive chemotherapy, and both attempted suicide by-removing large quantities of blood through the catheter.Despite the problems of assessment, psychiarc disorders are.common among patients with cancer, 2 and cancercan increase the risk of suicide.3In both these patiepis the Hickman catheter,,which.the patients mpulated daily tb selves, was an easy means of access tao the circulatin.Perhaps the insertion of.a Port-a-Cath would have ayoided this complication.
USE OF AIR PRESSURE TO SPEED UP BLOOD TRANSFUSION
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A cooperative model for provision of regional health services in a developing nation
Authors: C. D. Bessinger
Journal: JAMA (1984)

The development of health care in the Leogane region of Haiti has been a ten-year story of international cooperation among health professionals, of closely targeted assistance, and of policy coordination between assisting private agencies and the Haitian government. The broadly based health care program of l'Hopital Sainte Croix of Leogane is presented as a model of a cooperative effort that has resulted in rapid regional health care development and as an encouragement to the many differing types of groups responding to a world in medical need. (<i>JAMA</i>1984;252:3149-3151)
Predictors of Relapse in a Prospective Study of Fluoxetine Treatment of Major Depression
Authors: Patrick McGrath
Journal: American Journal of Psychiatry (2006)

Objective: Loss of response to a previously effective antidepressant is a common clinical problem. Retrospective analyses have shown that the pattern of response during antidepressant treatment (late onset and persistent versus other patterns) can be used to predict relapse during continuation and maintenance treatment and possibly to identify placebo responses to treatment. This study was designed to test the predictive value of response pattern prospectively and to examine the data for other predictors of relapse. Method: Five hundred seventy persons with major depressive disorder were treated with fluoxetine for 12 weeks and their pattern of response was determined. Those who responded (N=292) underwent random assignment, under double-blind conditions, to continue taking fluoxetine or to switch to placebo for 52 weeks or until relapse. Survival analysis was used to examine the effect of covariates on relapse. Results: Although fluoxetine was significantly more effective than placebo during maintenance treatment, this chronically ill group had a high rate of relapse. Contrary to previous findings, a pattern of acute response was not predictive of relapse. Chronicity, symptom severity, a neurovegetative symptom pattern, and female gender were all associated with a significantly greater risk of relapse, with no difference observed between fluoxetine and placebo. Conclusions: The pattern of response to acute treatment appears to be inconsistently predictive of relapse. There is a high rate of relapse with both active medication and placebo in patients with chronic depression. Illness characteristics predict loss of response both to fluoxetine and to placebo. No variable examined was predictive of differential relapse rates between fluoxetine and placebo.
Table of Contents
Authors: Christina Wyatt, W Reeves, Ewout Hoorn, David Severs, Ambreen Gul, Antonia Harford, Philip Zager, Mark Haas, Hernán Trimarchi, Jonathan Barratt, Daniel Cattran, H Cook, Viviana Palazzo, Aldesia Provenzano, Francesca Becherucci, Giulia Sansavini, Benedetta Mazzinghi, Valerio Orlandini, Laura Giunti, Rosa Roperto, Marilena Pantaleo, Rosangela Artuso, Elena Andreucci, Sara Bargiacchi, Giovanna Traficante, Stefano Stagi, Luisa Murer, Elisa Benetti, Francesco Emma, Mario Giordano, Francesca Rivieri, Giacomo Colussi, Silvana Penco, Emanuela Manfredini, Maria Caruso, Livia Garavelli, Simeone Andrulli, Gianluca Vergine, Nunzia Miglietti, Elena Mancini, Cristina Malaventura, Antonio Percesepe, Enrico Grosso, Marco Materassi, Paola Romagnani, Sabrina Giglio, Geir Mjøen, Hallvard Holdaas, Jayme Locke, Rhiannon Reed, Allan Massie, Dorry Segev, Jeries Zawaideh, Rodolfo Russo, Lorenzo Derchi, Abhilash Koratala, Volodymyr Chornyy, Ashutosh Shukla, Amir Kazory, Kuan-Chan Chen, Pauling Chu
Journal: Kidney International (2017)
Sensitivity of 6-[F-18]fluoro-L-dihydroxyphenylalanine positron emission tomography for localizing tumors causing catecholamine excess
Authors: H. Fiebrich, A. H. Brouwers, M. N. Kerstens, M. E. Pijl, I. P. Kema, J. R. de Jong, J. E. van der Wal, W. J. Sluiter, E. G. de Vries, T. P. Links
Journal: Journal of Clinical Oncology (2009)

11064 Background: Positron emission tomography (PET) using the catecholamine precursor 6-[F-18]fluoro-L-dihydroxyphenylalanine ( 18 F-DOPA) has emerged as promising technique to localize tumors with catecholamine excess. This study investigated the sensitivity of 18 F-DOPA PET, compared to 123 I-metaiodobenzylguanidine ( 123 I-MIBG) scintigraphy and computer tomography (CT)/ magnetic resonance imaging (MRI) in patients with catecholamine excess. Methods: In a single center prospective study 18 F-DOPA PET was compared to 123 I-MIBG and CT/MRI in patients with catecholamine excess. The performance of each imaging modality was analyzed for individual patients and individual lesions. 18 F-DOPA PET, 123 I-MIBG, and CT/MRI were compared using a composite reference standard derived from all available imaging, clinical and histological information. Sensitivities were calculated and discordance between imaging techniques was compared. 18 F-DOPA PET uptake was measured to determine whole body metabolic burden. Correlations between 18 F-DOPA PET imaging and biochemical data were evaluated. Results: 48 patients were included. The tumor localization was found in 45 patients, 43 with 18 F-DOPA PET, 31 with 123 I-MIBG and 32 with CT/MRI, resulting with surgery in final diagnosis of pheochromocytoma in 40, adrenal hyperplasia in 2, paraganglioma in 2, ganglioneuroma in 1 and 3 unknown (as yet no lesion detected). Per patient based analysis showed sensitivities for 18 F-DOPA PET, 123 I-MIBG and CT/MRI of 90, 65 and 67% (P&lt;.01 18 F-DOPA PET vs 123 I-MIBG, P&lt;.01 18 F-DOPA PET vs CT/MRI, P=1.0 123 I-MIBG vs CT/MRI). Corresponding sensitivities in the lesion based analysis were 73, 48 and 44%, respectively (P&lt;.001 for both 18 F-DOPA PET vs 123 I-MIBG and vs CT/MRI, P=.51 123 I-MIBG vs CT/MRI). The 8 F-DOPA PET+CT/MRI combination was superior to 123 I-MIBG+CT/MRI (93 vs 76%, P&lt;.001) Whole body metabolic burden measured with 18 F-DOPA PET correlated with plasma free normetanephrine (r=.82) and 24h urinary total normetanephrine (r=.84) and metanephrine (r=.57). Conclusions: The sensitivity of 18 F-DOPA PET to localize tumors with catecholamine excess is superior to either 123 I-MIBG scintigraphy or CT/MRI. No significant financial relationships to disclose.
Percutaneous transluminal coronary angioplasty: opportunity fleeting
Authors: D. H. Spodick
Journal: JAMA (1979)

Epidemiology as a scientific discipline and epidemiologists as practitioners are not clearly defined in the minds of most members of the healing arts. The etymology of the word (<i>epi</i>, upon;<i>demos</i>, the people) perhaps says it all—the study of how, where, when, and why a disease distributes itself over time within a population. It rests less on a body of knowledge and more on a way of thinking. Epidemiology had its beginnings from or in close association with medicine. The acute infectious and transmissible diseases were the first to be recognized as being due to a foreign agent. They were also demonstrated to be controllable by interrupting, in some way, the passage of an offending agent from a diseased person to another susceptible person with or without knowing the specific nature of the agent. The logic involved in this approach evolved into the epidemiologic triad of the agent, the vector
Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe
Journal: BMJ (2011)

Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and EuropeThe authors of this research paper-the DIPART (vitamin D Individual Patient Analysis of Randomized Trials) Group-have become aware of a coding error relating to treatment allocation in one of the studies (the Porthouse study) included in their pooled analysis (BMJ 2010;340:b5463, doi:10.1136/bmj.b5463).This error affects the data relating to studies of vitamin D plus calcium reported in table 2 andfigure 4. The authors have recalculated their data to take account of the error.They state that in table 2 the hazard ratios (and confidence intervals) shown in the "vitamin D 20 µg plus calcium" column should be 0.99 (0.84 to 1.19) for any fracture, 1.19 (0.81 to 1.75) for hip fracture, and 0.99 (0.49 to 2.04) for vertebral fracture [not 0.95 (0.80 to 1.14), 1.30 (0.88 to 1.92), 0.97 (0.48 to 1.98) respectively, as was published].In figure 4, the hazard ratio for hip fracture in CaD [calcium and vitamin D] trials should be 0.83 (0.69-0.99) [not 0.84 (0.70 to 1.01) as published], which is now statistically significant, and the hazard ratio for all trials should be 0.96 (0.85-1.09) [not 0.97 (0.86 to 1.10)].The authors state that the error led to a modest underestimation in their paper of the reduction in hip fracture risk for vitamin D supplements given with calcium, saying that "the results have been strengthened slightly by correcting this error and the reduction in hip fracture risk is now statistically significant."After correction, the absolute hip fracture risk reduction remained at 0.4% for participants aged over 70 and 0.2% in participants with previous fractures, but the numbers needed to treat (NNT) are now 250 and 524 (not 255 and 548).The NNT for all fractures was correct as reported.For more information on this, see the authors' Rapid Response (www.
A Glucocorticoid Receptor Gene Haplotype (TthIII1/ER22/23EK/9β) Is Associated with a More Aggressive Disease Course in Multiple Sclerosis
Authors: Lisa M. L. van Winsen, Laura Manenschijn, Elisabeth F. C. van Rossum, Bart A. Crusius, Jan Willem Koper, Chris H. Polman, Bernard M. J. Uitdehaag
Journal: Endocrine Reviews (2009)

In patients with multiple sclerosis (MS), glucocorticoids (GCs) might not be sufficiently able to restrain the immune system, possibly due to decreased GC sensitivity. This may be, at least partially, genetically determined. Previously, we reported a more aggressive disease course in patients with the glucocorticoid receptor (GR) gene ER22/23EK polymorphism, which has been shown to decrease GC sensitivity. In 646 MS patients and 317 healthy controls, we investigated whether haplotypes, including the ER22/23EK polymorphism or the GR 9β polymorphism, which is also associated with a relative GC resistance, were associated with a more aggressive disease course. Polymorphisms in the GR gene (9β, ER22/23EK, TthIIII, BclI, and N363S), which have previously been associated with altered GC sensitivity. We evaluated whether the haplotypes were associated with disease susceptibility and several other disease characteristics. The association with disease progression was analyzed using Cox regression with time to Expanded Disability Status Score 6 as outcome. None of the haplotypes was associated with disease susceptibility, age at onset, or onset type. Haplotype 6 (TthIIII, ER2223EK, and 9β-G) was associated with a more rapid disease progression (hazard ratio 2.3; 95% confidence interval 1.5–3.7; P < 0.001). This seems to result from the presence of ER22/23EK, and not from the 9β and TthIIII polymorphisms. MS patients carrying the haplotype 6 (TthIIII, ER22/23EK, and 9β) have a more aggressive disease course. This is probably due to the presence of the polymorphism ER22/23EK, which causes a decreased GC sensitivity.
Massachusetts Medical Society
Authors: Michael A. Tighe
Journal: New England Journal of Medicine (1946)

SPECIAL MEETING OF THE COUNCIL January 9, 1946A SPECIAL meeting of the Council was called to order by the president, Dr. Reginald Fitz, on Wednesday, January 9, 1946, at 3:00 p.m., in John Ware Hall, 8 Fenway, Boston. Dr. Michael A. Tighe served as secretary.The business before this meeting was the report of the Postwar Planning Committee, which concerned itself with certain basic principles considered essential to a medical-care plan, the Wagner–Murray–Dingell Act (Senate 1606), and the Maternal and Child Welfare Act of 1945 (Senate 1318).The report of the committee presented by Dr. Howard F. Root, Suffolk, . . .
Primary Atypical Pneumonia due to Mycoplasma Pneumoniae: Report of a Case with Residual Pleural Abnormality
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive factors of symptomatic nodular regenerative hyperplasia after liver transplantation
Authors: Ilias Kounis, Manon Evain, Mylène Sebagh, Bruno Roche, Eleonora De Martin, Rodolphe Sobesky, Eric Vibert, Jean-Charles Duclos-Vallée, Cyrille Feray, Didier Samuel, Audrey Coilly
Journal: Journal of Hepatology (2020)
Hantavirus Nephropathy
Authors: Dus[Combining Caron] Ferluga, Alenka Vizjak
Journal: Journal of the American Society of Nephrology (2008)

Pathogenic rodent-borne hantaviruses cause in humans generalized infections that involve the peripheral vascular bed and severely affect their permeability. We describe a 30-yr-old male patient with clinical symptoms characterizing five conventional phases of hemorrhagic fever with renal syndrome after an uncommonly severe hantavirus infection with the Puumala strain. Renal biopsy in this situation typically demonstrates acute hemorrhagic interstitial nephritis, particularly pronounced in the outer medulla. Hantaviruses are not cytopathic for most cells, and their interactions with endothelial cells that activate immune mechanisms play a key role in the pathogenesis of vascular dysfunction characterizing this disease.
Long-term effects of levodopa in the severely disabled patient
Authors: O. W. Sacks
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In the editorial, "Half Life of Eponyms" (<b>213</b>:456, 1970), the second sentence reads: "It may find poetic expression in Ovid's `Exegi monumentum'." This famous poem is by Horace (Quintus Horatius Flaccus). Exegi monumentum aere perennius Regalique situ pyramidum altius, Quod non imber edax, non Aquilo impotens Possit diruere, aut innumerabilis Annorum series et fuga temporum. Non omnis moriar. I have raised a monument more lasting than bronze, Loftier than the royal peak of pyramids; No biting storm can bring it down, No impotent north wind, nor the unnumbered series Of the years, nor the swift course of time. I shall not wholly die.
Gamma Motoneuron Control by Thalamus and Globus Pallidus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal