tbuckley/cabot-search huggingface dataset:
Comment on: Screening for Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) among Endometrial Cancer Patients
Authors: Heather Hampel, Jenny Panescu, Janet Lockman, Kaisa Sotamaa, Daniel Fix, Ilene Comeras, Jennifer LaJeunesse, Hidewaki Nakagawa, Judith A. Westman, Thomas W. Prior, Mark Clendenning, Albert de la Chapelle, Wendy Frankel, Pamela Penzone, David E. Cohn, Larry Copeland, Lynne Eaton, Jeffrey Fowler, Janet Lombardi, Patti Dunn, Jeffrey Bell, Gary Reid, George Lewandowski, Luis Vaccarello
Journal: Cancer Research (2007)

To the Editor:This correspondence is an addendum to our recent report (1) about the prevalence of Lynch syndrome among all newly diagnosed endometrial cancer patients. Two additional deleterious MSH6 gene mutations were found on completion of molecular analysis in the last 19 patients. In addition, RNA studies have allowed the reclassification of one of the presumptive missense mutations c.1304T>C (p.Leu435Pro) from the original report as a deleterious frameshift mutation. As a result, the prevalence of Lynch syndrome in our cohort of Columbus, OH area endometrial cancer patients has increased from 1.8% to 2.3% (95% confidence interval, 1.3–4.0%). This is an important update as many institutions and policy groups are considering whether to implement screening for Lynch syndrome among endometrial cancer patients.We reported 10 Lynch syndrome cases out of 543 patients with completed molecular analysis and a total of 564 patients on study. Two patients have since been removed from study for insufficient tumor material, leaving 562 patients on study. Molecular analysis has now been performed in the 19 patients who did not have testing completed at the time of publication. Two of the 19 patients were found to have nonsense mutations in MSH6. Case 18 is a Caucasian female with mixed endometrioid and clear cell carcinoma diagnosed at age 58 years whose family history meets the Bethesda guidelines (2). Her tumor was microsatellite instability (MSI) high, immunohistochemistry was absent for MSH6 only, and she was found to have a c.3768T>G (p.Tyr1256X) mutation. Case 1079 is an African-American patient diagnosed with endometrioid carcinoma at age 51 years whose family history does not meet any published Lynch syndrome criteria. Her tumor failed MSI testing; however, immunohistochemistry staining indicated the absence only of MSH6 so sequencing of the MSH6 gene was performed. She was found to have a c. 220G>T (p.Gly74X) mutation. Finally, we reported that case 1493 was found to have a c.1304T>C (p.Leu435Pro) mutation in MSH6, which was a sequence change of unknown significance. Reverse transcription-PCR run on a gel clearly displays exon skipping. Sequencing of the patient's cDNA verifies aberrant splicing causing skipping of exon 4 in MSH6. Overall, with these additions, 8 of the 13 (61.5%) cases were diagnosed at age 50 years or later, 8 did not meet any of the published family history criteria for the diagnosis of Lynch syndrome, and 2 would have been missed by MSI testing (1 negative and 1 failed).
AUSTRALIA
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tinea Nigra
Authors: ALDO CASTELLANI
Journal: British Journal of Dermatology (1964)

Journal Article Tinea Nigra Get access ALDO CASTELLANI ALDO CASTELLANI Lisbon Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 3, 1 March 1964, Pages 149–150, https://doi.org/10.1111/j.1365-2133.1964.tb14496.x Published: 01 March 1964
Antibodies to Gastric Mucosa and Thyroid in Diabetes Mellitus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characteristic traumatic skin lesions in drug-induced coma
Authors: S. Mandy
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doctors' Pay
Authors: J. M. Lyons, C. P. Carey, M. Conway, G. Robinson, K. Haywood, E. Buckley, M. C. Flasher, M. Morkos, P. O'Flynn, A. Gerrard, P. M. Scott, T. E. Danaldson, J. L. Hay, I. R. Lurie, A. I. Mclean, S. C. Noble, M. Sanders, C. W. Orr, S. Lunt
Journal: BMJ (1964)
Delirium at the End of Life
Authors: David Casarett, Sharon Inouye
Journal: Annals of Internal Medicine (2002)

Letters20 August 2002Delirium at the End of LifeDavid Casarett, MD, MA and Sharon Inouye, MD, MPHDavid Casarett, MD, MAVeterans Affairs Medical Center; Philadelphia, PA 19104 (Casarett)Yale University; New Haven, CT 06520Search for more papers by this author and Sharon Inouye, MD, MPHVeterans Affairs Medical Center; Philadelphia, PA 19104 (Casarett)Yale University; New Haven, CT 06520Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-4-200208200-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Finucane correctly points out that few data are available to guide the management of delirium in patients near the end of life. We strongly agree that research to guide the treatment of delirium is urgently needed, and this fact was a major area of emphasis in our article. However, in the absence of evidence from robust clinical trials, our recommendations are based on evidence provided by the medical literature, consensus of expert opinion, and our clinical experience in the care of patients at the end of life. In fact, the American College of Physicians–American Society of Internal ...References1. Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, et al . A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry. 1996;153:231-7. [PMID: 8561204] CrossrefMedlineGoogle Scholar2. Trzepacz PT. The neuropathogenesis of delirium. A need to focus our research. Psychosomatics. 1994;35:374-91. [PMID: 7916159] CrossrefMedlineGoogle Scholar3. Platt MM, Breitbart W, Smith M, Marotta R, Weisman H, Jacobsen PB. Efficacy of neuroleptics for hypoactive delirium [Letter]. J Neuropsychiatry Clin Neurosci. 1994;6:66-7. [PMID: 7908548] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Veterans Affairs Medical Center; Philadelphia, PA 19104 (Casarett)Yale University; New Haven, CT 06520 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDiagnosis and Management of Delirium near the End of Life David J. Casarett , Sharon K. Inouye , and Delirium at the End of Life Thomas E. Finucane Metrics 20 August 2002Volume 137, Issue 4Page: 295KeywordsClinical trialsDeliriumEnd of life careForecastingHallucinationsPalliative carePatientsSchizophreniaSedationToxicity ePublished: 20 August 2002 Issue Published: 20 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Incorrect Unit of Measure
Authors: D Hester, Leah Eisenberg, Laura Guidry-Grimes, D Micah Hester, Erin Demartino, Cavan Doyle, Paul Mueller
Journal: JAMA (2019)

Intramyocardial Injection of Mesenchymal Precursor Cells and Weaning From Left Ventricular Assist Device (LVAD) Support
Radiotherapy and concomitant weekly carboplatin and daily etoposide for patients with inoperable biopsy proven glioblastoma multiforme
Authors: J. M. Simon, G. Noel, K. Hoang-Xuan, A. F. Carpentier, K. Mokhtari, S. Racadot, F. Baillet, J. J. Mazeron
Journal: Journal of Clinical Oncology (2004)

1544
Tap seizures. A form of sensory precipitation epilepsy
Authors: R. Calderon-Gonzalez
Journal: JAMA (1966)

Four patients suffered from seizures (myoclonic and akinetic) precipitated almost exclusively by touch or light tap, mainly over the head or shoulders. Other sensory stimuli did not elicit an attack. Clinical evidence of diffuse brain damage from birth was present in all of them. The attacks developed before 2 years of age and were as frequent as 50 or more each day. Electroencephalographic recording during seizures revealed a similar pattern in all patients. Tactile stimulation evoked long-latency (60 to 125 msec), brief bursts of widespread, bilaterally synchronous and symmetrical EEG discharges. They occurred before, synchronous with, or after the myoclonus. A defective descending inhibitory system may lead to development of both the EEG discharges and the myoclonus in response to a peripheral sensory stimulus.
Exhaled nitric oxide and sputum eosinophil markers of inflammation in asthmatic children
Authors: G.L. Piacentini, A. Bodini, S Costella, L. Vicentini, P. Mazzi, S. Sperandio, A.L. Boner
Journal: European Respiratory Journal (1999)

The relationship between nitric oxide in exhaled air, levels of sputum eosinophils, sputum eosinophil cationic protein (ECP) and urinary eosinophil protein X (EPX) excretion has not yet been investigated in corticosteroid-dependent childhood asthma. Therefore, taking 25 children with stable asthma (mean age 11.2 yrs) treated with inhaled corticosteroids and nine nonatopic healthy control children (mean age 12.8 yrs) the level of exhaled NO was measured by means of a chemiluminescence analyser before and after sputum induction. This was conducted as a slow vital capacity manoeuvre under standardized conditions with a target flow of 70 mL x s(-1) against a resistance of 100 cm H2O x L(-1) x s. Sputum induction was performed by inhalation of hypertonic saline (3, 4, and 5%) in a standardized manner and a single sample of urine was collected. Exhaled NO (p = 0.01), absolute eosinophil cell counts in sputum (p = 0.02), sputum ECP (p = 0.09) and urinary EPX excretion (p = 0.02) were higher in asthmatics compared to control children. Exhaled NO was positively correlated with sputum ECP (r(s) = 0.59, p = 0.002), urinary EPX (r(s) = 0.42, p = 0.03), and sputum eosinophils (r(s) = 0.30, p = 0.15) in the asthmatic children. These correlations appeared to be pronounced after sputum induction, where NO values had decreased (p = 0.01). None of the correlations were observed in the group of nonatopic control subjects. Additionally there were significant correlations between sputum ECP and sputum eosinophils (r(s) = 0.69, p&lt;0.001) as well as between sputum ECP and urinary EPX excretion (r(s) = 0.58, p = 0.003) in the asthmatics. Exhaled NO provides information about the degree of eosinophilic airway inflammation and thus appears to be a useful and easy-to-perform inflammatory marker in corticosteroid-dependent asthma.
P values
Authors: P. Sedgwick
Journal: BMJ (2010)

A randomised controlled trial evaluated the cost and efficacy of community leg ulcer clinics that used four layer compression bandaging.1 The control treatment was provision of usual care by district nurses. Over the 12 months of follow-up, ulcers healed more quickly among patients randomly assigned to clinic treatment than in those assigned to the control treatment (P=0.03). On the other hand, there was no difference between treatment groups in mean total NHS costs per patient (P=0.89). All statistical tests were two sided, and the critical level of significance was set at 0.05 (5%). Which of the following statements, if any, can be concluded?
The Work of the Digestive Glands.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: C. J. LOGOTHETIS
Journal: JNCI Journal of the National Cancer Institute (1991)

BOOK REVIEWS Get access Neoadjuvant Chemotherapy in Invasive Bladder Cancer: Progress in Clinical and Biological Research, Volume 353 . Ted A. W. Splinter , Howard I. Scher eds. New York : WileyLiss , 1990 , 241 pp, $69.95. CHRISTOPHER J. LOGOTHETIS CHRISTOPHER J. LOGOTHETIS Genitourinary Oncology Department, Department of Medical Oncology, M. D. Anderson Cancer Center, University of Texas1515 Holcombe Blvd. Houston, TX 77030 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 11, 5 June 1991, Page 786, https://doi.org/10.1093/jnci/83.11.786 Published: 05 June 1991
Need for primary health care: an objective indicator
Authors: A. Scott-Samuel
Journal: BMJ (1984)

In patients with substituted hypothyroidism, laparoscopic sleeve gastrectomy may interfere with thyroid balance by varying body weight or by altering the absorption of hormone therapy. A 58-year-old female patient presented with a major thyroid imbalance after sleeve gastrectomy, manifesting itself in large-scale changes in thyroid stimulating hormone (TSH) levels. The transition from a tablet treatment to a liquid form alleviated burden of treatment, unfortunately without normalising TSH. Our case emphasises the importance of the understanding of hypothalamic–pituitary–thyroid feedback control mechanisms together with good galenic choice, management of associated conditions and the elimination of other causes of variations of TSH levels during the management of hypothyroid patients after sleeve gastrectomy.
Phytoremediation of Trichloroethylene with Hybrid Poplars
Authors: Milton Gordon, Nami Choe, Jim Duffy, Gordon Ekuan, Paul Heilman, Indulis Muiznieks, Marty Ruszaj, B. Brook Shurtleff, Stuart Strand, Jodi Wilmoth, Lee A. Newman
Journal: Environmental Health Perspectives (1998)

Axenic tumor cultures of poplar cells, clone H11-11, were grown in the presence of [14CO-trichloroethylene (TCE) (uniformly labeled).The cells were capable of metabolizing TCE to produce trichloroethanol, di-and trichloroacetic acid.Some of the carbon from TCE was found in insoluble, nonextractable cell residue, and small amounts were mineralized to [14C0C02.Poplar cuttings grown in soil and exposed to TCE produced the same metabolites.In field trials, trees were planted in soil in test cells and exposed to TCE via underground water injection during the growing season.During the growing season, at least 95% of the TCE was removed from the influent water stream in cells containing trees.Mass balance studies conducted in the laboratory indicated that 70 to 90% of the TCE was transpired; however, greenhouse and field study results showed that less than 5% of the total TCE taken up by the plants is transpired.These results show that significant TCE uptake and degradation occur in poplars.Poplars appear to be useful for in situ remediation of TCE-contaminated sites under proper conditions.
Abstract 261: Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rγnull immunodeficient mice
Authors: Miguel F. Sanmamed, Inmaculada Rodriguez, Carmen Oñate, Arantza Azpilikueta, Maria E. Rodriguez-Ruiz, Aizea Morales-Kastresana, Sara Labiano, Jose L. Perez-Gracia, Salvador Martín-Algarra, Carlos Alfaro, Kurt A. Schalper, Guillermo Mazzolini, Francesca Sarno, Manuel Hidalgo, Alan J. Korman, Maria Jure-Kunkel, Ignacio Melero
Journal: Cancer Research (2015)

Abstract To evaluate the pharmacodynamics effects and antitumor activities of immunostimulatory mAb, we have developed a “humanized” murine model in which the receptors targeted by such mAbs become expressed. Human lymphocytes transferred into immunodeficient mice undergo activation and redistribute to organs with surface expression of hCD137 and hPD-1. Systemic lymphocyte infiltrations result in lethal xenograft-versus-host disease, which is aggravated when mice are given clinical-grade anti-hCD137 (urelumab) and anti-hPD-1 (nivolumab) mAbs. In mice engrafted with either a human colorectal carcinoma cell line (HT-29) and allogeneic human PBMCs or a primary gastric carcinoma and PBMCs from the patient, urelumab and nivolumab significantly slowed tumor growth (p&amp;lt;0.01). Increased activated human T lymphocytes producing IFN-ϒ and decreased human regulatory T lymphocytes in the xenografted tumors may explain such therapeutic activities. These mouse models permit surrogate analyses to test and make predictions on immunotherapy strategies encompassing immunostimulatory mAbs and their combinations. Citation Format: Miguel F. Sanmamed, Inmaculada Rodriguez, Carmen Oñate, Arantza Azpilikueta, Maria E. Rodriguez-Ruiz, Aizea Morales-Kastresana, Sara Labiano, Jose L. Perez-Gracia, Salvador Martín-Algarra, Carlos Alfaro, Kurt A. Schalper, Guillermo Mazzolini, Francesca Sarno, Manuel Hidalgo, Alan J. Korman, Maria Jure-Kunkel, Ignacio Melero. Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rγnull immunodeficient mice. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 261. doi:10.1158/1538-7445.AM2015-261
Infectious Diseases
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal