tbuckley/cabot-search huggingface dataset:
Comparison of enoximone echocardiography, positron emission tomography and dobutamine echocardiography for prediction of recovery of myocardial dysfunction after revascularization
Authors: C. Lu, M. Cartino, C. Landoni, A. Cappelletti, F. Maisano, A. Margonato, G. Lucignani, F. Fazio, S.L. Chierchia
Journal: Journal of the American College of Cardiology (1998)
1010 ENTERAL NUTRITION WITH OR WITHOUT N-ACETYLCYSTEINE IN THE TREATMENT OF SEVERE ACUTE ALCOHOLIC HEPATITIS: A RANDOMIZED, MULTICENTER, CONTROLLED TRIAL
Authors: C. Moreno, P. Langlet, A. Hittelet, S. Evrard, L. Lasser, I. Colle, A. Lemmers, J. Devière, O. Le Moine
Journal: Journal of Hepatology (2009)
Abstract 4131: MEK inhibitor diminishes nasopharyngeal carcinoma (NPC) cell growth and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expression
Authors: Yu Zhu, Qiong Song, Yi Lu
Journal: Cancer Research (2015)

Abstract Nasopharyngeal carcinoma (NPC) is a common malignant cancer in Guangxi, as well as in southern China and Southeast Asia. NPC preferentially metastasizes to bone in advanced patients, major factor resulting in high mortality. The molecular basis of NPC development and cancer-induced bone lesions are still unclear. We and others have reported that chemokine, like CCL2, CXCL16, CXCL12, and their corresponding receptors played important roles in cancer bone metastasis. In this study, we firstly investigated that CCR2 and CXCR6 expressions in clinical specimens. Then, we measured CCL2, CCR2, CXCL16 and CXCR6 expression levels by RT-PCR, ELISA and western blot in NPC cell lines. Further, we used MEK inhibitor, U0126, to treat the NPC cell lines and found CCL2 and CXCL16 expressions significantly decreased. The NPC cell lines proliferation were inhibited by U0126 in dose- and time-dependently manner. Finally, we collected conditioned medium (CM) from the NPC cell lines absent or present U0126 treatments, to treat mouse bone marrow non-adherent cells in order to detect NPC CM-induced multinucleated osteoclast-like formation. The CMs collected from U0126 treated NPC cells were dramatically diminished the numbers of multinucleated osteoclasts. These results indicate that U0126 inhibits NPC cell growth and diminishes cancer-induced osteoclast formation partially through modulating the expression of CCL2 and CXCL16. Thus this study may provide a novel therapeutic strategy for advanced NPC patients, especially for treatment of NPC bone metastasis. Citation Format: Yu Zhu, Qiong Song, Yi Lu. MEK inhibitor diminishes nasopharyngeal carcinoma (NPC) cell growth and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expression. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4131. doi:10.1158/1538-7445.AM2015-4131
INFLUENZA.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Horizons: Future Directions in Neurotoxicology
Authors: Hugh A. Tilson
Journal: Environmental Health Perspectives (2000)

Neurotoxicology is a relatively young discipline that has undergone significant growth during the last 25 years.During the late 1970s and 1980s, numerous national and international conferences and meetings were devoted to the topic of neurotoxicology, the formation of societies or specialty sections related to neurotoxicology, and the establishment of two independent peer-reviewed journals devoted to neurotoxicology.This decade was also associated with a rapid increase in our knowledge of chemical effects on the structure and function of the nervous system.During the 1990s, regulatory agencies such as the U.S. Environmental Protection Agency accepted neurotoxicology as a crucial end point and neurotoxicity testing and risk assessment guidelines were published.Neurotoxicology has also been accepted at the international level as evidenced by environmental criteria documents published by the International Programme on Chemical Safety and testing guidelines by the Organization of Economic Cooperation and Development.In recent years, there has been increased concern that the etiology of some neurodegenerative diseases may be associated with exposure to neurotoxic agents and that subpopulations of humans such as children and the elderly may be differentially sensitive to neurotoxic exposure.In the future, mechanistic information derived from basic research will be used in the identification and characterization of chemicals with neurotoxic potential.
Ultrasonic testing in human renal allografts
Authors: A. R. Winterberger
Journal: JAMA (1972)

B-scan ultrasonography was used as an aid in the evaluation of 15 human renal allotransplantations. Repeated studies detect changes in the kidney outline and the kidney cross-section, and the presence of abnormal acoustic interfaces in the perirenal areas. Over 70 studies were completed in this series. Of six cases of graft injection with functional, angiographic, radioactive isotope, and histologic confirmation, four showed a corresponding increase in size by ultrasonic laminography during the acute rejection phase, with reversal following correction of rejection. Seven cases of perirenal fluid collection caused by either lymph or other fluids were generally asymptomatic but were confirmed in four cases by subsequent clinical studies. They were initially discovered by this technique. Ultrasonic laminography is readily adaptable for the initial and follow-up evaluation of patients undergoing human renal allotransplants.
Chronic relapsing thrombotic thrombocytopenic purpura: Role of therapy with cyclosporine
Authors: Donald Pasquale, Rakesh Vidhya, Karen DaSilva, Min‐Fu Tsan, Lawrence Lansing, G. Chikkappa
Journal: American Journal of Hematology (1998)

Relapsing thrombotic thrombocytopenic purpura (TTP) is a rare disorder with most individuals experiencing 1 to 5 relapses. We report a patient with 18 episodes of thrombotic thrombocytopenic purpura (TTP), the highest number of relapses thus far described. The last 11 episodes were treated with regimens containing cyclosporine. The patient's medical record was reviewed for pertinent clinical, laboratory, and treatment data. We summarized various parameters for each episode and compared characteristics of relapses treated with vs. without cyclosporine. The initial episode of TTP was unusual in that it failed to respond to plasmapheresis, glucocorticoids, and fresh frozen plasma (FFP). It remitted only following splenectomy. Episodes 2–7 responded to FFP plus prednisone. Episode 8 failed to respond to prednisone plus FFP but remitted promptly with cyclosporine plus prednisone. Subsequently, 2 relapses responded to cyclosporine alone, 2 to cyclosporine plus FFP, 4 to cyclosporine plus prednisone ± FFP, and 2 to cyclosporine, FFP, prednisone, and plasma exchange. There was no difference in remission duration, or in severity or duration of relapses treated with vs. without cyclosporine. Use of cyclosporine, however, significantly decreased the requirement for prednisone and the length of maintenance therapy; thus it is effective mainly as an adjunctive therapy for TTP. Am. J. Hematol. 57:57–61, 1998. Published 1998 Wiley-Liss, Inc.1 This article is a U.S. Government work and, as such, is in the public domain in the United States of America.
Sperm swim singly after vitamin C therapy
Authors: E. R. Gonzalez
Journal: JAMA (1983)

Swallow a gram of ascorbic acid daily and restore fertility in just four days? It sounds implausible, to say the least. But Earl B. Dawson, PhD—with colleagues William A. Harris and William J. McGanity, MD, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston—has recently shown that this may be possible in men with infertility secondary to nonspecific sperm agglutination. At the recent meeting of the Federation of American Societies for Experimental Biology in Chicago, Dawson reported on a study of 35 male patients who could not impregnate their wives because more than 20% (mean, 37%) of their sperm clumped together, as demonstrated by microscopic studies of semen samples. The men's serum ascorbic acid levels averaged 0.2 mg/dL, which is considered borderline by the US National Nutrition Research Council, in contrast to a normal level of 0.6 to 0.8 mg/dL. Semen levels of the vitamin averaged 4.2 mg/dL.
DIAGNOSIS OF MALARIAL AND TYPHOID FEVERS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anticardiolipin Antibodies and Hypercoagulability
Authors: David C. Hess
Journal: Annals of Internal Medicine (1993)

Letters15 June 1993Anticardiolipin Antibodies and HypercoagulabilityDavid C. Hess, MDDavid C. Hess, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-12-199306150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The failure to find anticardiolipin antibodies a risk factor for ischemic stroke may have more to do with the design of the Physicians' Health Study than the actual absence of the antibodies in stroke patients [1].Rosove and Brewer [2] reported that the initial site of thrombosis in patients with antiphospholipid antibodies tended to predict the site of subsequent events. Patients with venous thrombosis tended to have recurrent venous thrombosis, whereas patients with arterial events such as stroke tended to have recurrent stroke and not a venous event. Patients were excluded from the Physicians' Health Study if ...References1. Ginsburg KS, Liang MH, Newcomer L, Goldhaber SZ, Schur PH, Hennekens CH, et al. Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. Ann Intern Med. 1992; 117: 997-1002. Google Scholar2. Rosove MH, Brewer PMC. Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Ann Intern Med. 1992; 117:303-8. Google Scholar3. Brey RL, Hart RG, Sherman DG, Tegeler CH. Antiphospholipid antibodies and cerebral ischemia in young people. Neurology. 1990; 40:1190-6. Google Scholar4. Hess DC, Krauss J, Adams RJ, Nichols FT, Zhang DL, Rountree HA. Anticardiolipin antibodies: A study of frequency in TIA and stroke. Neurology. 1991; 41:525-8. Google Scholar Author, Article, and Disclosure InformationAuthors: David C. Hess, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA subgroup of multiple sclerosis patients with anticardiolipin antibodies and unusual clinical manifestations: Do they represent a new nosological entity? 15 June 1993Volume 118, Issue 12Page: 986-987KeywordsAge groupsAntibodiesBlood plasmaDeep vein thrombosisIschemic strokeMedical risk factorsStrokeThrombosisTransient ischemic attacks ePublished: 15 August 2000 Issue Published: 15 June 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Pediatric Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
Authors: Ian K. Maconochie, Richard Aickin, Mary Fran Hazinski, Dianne L. Atkins, Robert Bingham, Thomaz Bittencourt Couto, Anne-Marie Guerguerian, Vinay M. Nadkarni, Kee-Chong Ng, Gabrielle A. Nuthall, Gene Y.K. Ong, Amelia G. Reis, Stephen M. Schexnayder, Barnaby R. Scholefield, Janice A. Tijssen, Jerry P. Nolan, Peter T. Morley, Patrick Van de Voorde, Arno L. Zaritsky, Allan R. de Caen, Alex Moylan, Alexis Topjian, Kevin Nation, Shinchiro Ohshimo, Ronald A. Bronicki, Kelly D. Kadlec, Lynda J. Knight, Taylor N. McCormick, Ryan W. Morgan, Joan S. Roberts, Sarah Tabbutt, Ravi Thiagarajan, Brian Walsh, Tia Raymond, Melissa Chan, Jonathan P. Duff, Benny L. Joyner, Javier J. Lasa, Arielle Levy, Kathryn E. Roberts, Robert M. Sutton, Nieves de Lucas, Florian Hoffmann, Nigel Turner, Dominique Biarent, Torsten Lauritsen, Olivier Brissaud, Groa Johannesdottir, Jana Djakow, Abel Martinez Mejias, Garth Meckler, Matt Buchanan, Laurie J. Morrison
Journal: Circulation (2020)

This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) for pediatric life support is based on the most extensive evidence evaluation ever performed by the Pediatric Life Support Task Force. Three types of evidence evaluation were used in this review: systematic reviews, scoping reviews, and evidence updates. Per agreement with the evidence evaluation recommendations of the International Liaison Committee on Resuscitation, only systematic reviews could result in a new or revised treatment recommendation. Systematic reviews performed for this 2020 CoSTR for pediatric life support included the topics of sequencing of airway-breaths-compressions versus compressions-airway-breaths in the delivery of pediatric basic life support, the initial timing and dose intervals for epinephrine administration during resuscitation, and the targets for oxygen and carbon dioxide levels in pediatric patients after return of spontaneous circulation. The most controversial topics included the initial timing and dose intervals of epinephrine administration (new treatment recommendations were made) and the administration of fluid for infants and children with septic shock (this latter topic was evaluated by evidence update). All evidence reviews identified the paucity of pediatric data and the need for more research involving resuscitation of infants and children.
Adolescent Health and the Environment
Authors: Mari S. Golub
Journal: Environmental Health Perspectives (2000)

The effects of toxicants depend on the dose and the time in the life span when exposure occurs. The biology of adolescence is distinctive and provides opportunities for unique actions of toxicants both in terms of disruption of function and disruption of maturation. Maturation of a number of organ systems occurs during this period, including not only the reproductive system but also the respiratory, skeletal, immune, and central nervous systems. Adolescence is a time of increased risk for infectious disease and accidental injury, making the effects of toxicants on the immune and central nervous systems particularly harmful. Differences in blood volume, respiratory parameters, metabolic needs, and capacity all contribute to altered pharmacokinetics. Exposures can also change. Increased food intake associated with rapid adolescent growth alters exposure to food contaminants. Voluntary drug consumption increases, including drinking; smoking; substance abuse; and the use of over-the-counter, prescription, and performance-enhancing drugs. At the same time, adolescents are introduced to toxicants in the workplace. Basic research in the toxicology of adolescence needs to take into account the appropriateness of animal models for this distinctive human developmental stage; risk assessment must take into account pharmacokinetic and lifestyle factors. Screening methodologies that would identify toxic effects unique to adolescence would also be valuable.
Thomas Campion: lyrick-doctor in physicke
Authors: P. J. Davis
Journal: JAMA (1969)

The fame of Thomas Campion was interred with him in 1620. Called by Kastendieck the finest poet-musician of the Elizabethan period, he was ranked by his peers with Philip Sidney, Jonson, Donne, and Shakespeare and was known widely as a Doctor in Physicke. His ayres—terse musical poems either erotic or patently religious—represent the most significant efforts of his era to break away from madrigals and repetitive rhyming which were the standard 16th-century musical and poetic forms. A unique musical theoretician whose works were neglected for nearly three centuries, Campion today remains at best a comfortably obscure poet in literary anthologies, unmentioned in texts of medical history and musically unaccredited. Well into his ayre-writing career, he had come reluctantly to the study of medicine as his personal fortune dwindled and he required a legitimate source of income. Thomas Campion was born in Hertfordshire in 1567, the only son of litigious minor
Gun Violence
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Charter on Medical Professionalism: Putting the Charter into Practice
Authors: Neil J. Smelser
Journal: Annals of Internal Medicine (2003)

Letters20 May 2003Charter on Medical Professionalism: Putting the Charter into PracticeNeil J. Smelser, PhDNeil J. Smelser, PhDUniversity of California, Berkeley; Berkeley, CA 94704 (Smelser)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-10-200305200-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:It is entirely appropriate for Drs. Lippi, Gensini, and Conti to highlight the Hippocratic Oath, since the members of the Medical Professionalism Project referred to it only briefly in the preamble to the physician charter. It is also important for us to clarify the role that the Oath played in our thinking. We consider the Hippocratic Oath to have much more than ritual significance, as implied by the authors' use of the terms respectability and group solidarity. We believe, on the contrary, that the Oath does represent the ethics currently common to physicians. However, it does so in ... Author, Article, and Disclosure InformationAuthors: Neil J. Smelser, PhDAffiliations: University of California, Berkeley; Berkeley, CA 94704 (Smelser) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMedical Professionalism in the New Millennium: A Physician CharterCharter on Medical Professionalism: Putting the Charter into Practice Jerome C. Arnett Jr. Charter on Medical Professionalism: Putting the Charter into Practice Sylvia L. Cruess and Richard L. Cruess Charter on Medical Professionalism: Putting the Charter into Practice Robert Feldman Charter on Medical Professionalism: Putting the Charter into Practice Walter J. McDonald Charter on Medical Professionalism: Putting the Charter into Practice Steven A. Wartman Charter on Medical Professionalism: Putting the Charter into Practice Jordan J. Cohen Charter on Medical Professionalism: Putting the Charter into Practice Yevgeniya Nusinovich Charter on Medical Professionalism: Putting the Charter into Practice Risa Lavizzo-Mourey Charter on Medical Professionalism: Putting the Charter into Practice Christopher J. Lyons Charter on Medical Professionalism: Putting the Charter into Practice Richard L. Cruess and Sylvia L. Cruess Charter on Medical Professionalism: Putting the Charter into Practice Sadeq A. Quraishi and Ayesha N. Khalid Charter on Medical Professionalism: Putting the Charter into Practice Neil J. Smelser Charter on Medical Professionalism: Putting the Charter into Practice Charles M. Haskell Charter on Medical Professionalism: Putting the Charter into Practice Neil J. Smelser Charter on Medical Professionalism: Putting the Charter into Practice Donatella Lippi , GianFranco Gensini , and Andrea A. Conti Metrics 20 May 2003Volume 138, Issue 10Page: 853 ePublished: 20 May 2003 Issue Published: 20 May 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evaluation of headache
Authors: J. I. Ordia
Journal: JAMA (1981)

<h3>In Reply.—</h3> Computed axial tomography has proved to be a powerful tool in the noninvasive neurodiagnostic evaluation because of the superb diagnostic accuracy and minimal patient risk involved. Consequently, the CT scanner is inherently subject to excessive use. The advisability of restricting CT scanning in patients with headache to those having abnormalities in their neurological examination has been discussed as a means for lessening the economic burden. Drs Ordia and Mark have posed several circumstances under which potentially hazardous intracranial lesions may be present without notable neurological abnormality on examination. Their comments are entirely appropriate and describe problems encountered in active clinical practice. Midline posterior fossa lesions causing hydrocephalus from fourth ventricular outflow obstruction, pinealomas, and giant aneurysms are other entities that may be present without obvious neurological signs. CT scanning may obviate the need for lumbar puncture in a patient suspected of having subarachnoid hemorrhage by documenting the presence