tbuckley/cabot-search huggingface dataset:
Thoraxchirurgie, Stuttgart
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EUTHANASIA.EUTHANASIA.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RENAL TUBERCULOSIS
Authors: GILBERT J. THOMAS
Journal: JAMA (1930)

About ten years ago I became interested in the study of renal tuberculosis because it seemed to me that in some way we should be able to arrest this condition before the kidney is destroyed and before the bladder becomes so impaired that it causes chronic invalidism. The hope that I might learn something about the early lesion of renal tuberculosis encouraged me to begin this clinical and pathologic study in the Hennepin County Sanatorium at Glen Lake, Minn. Among the patients in the sanatorium I observed many who had proved urinary tuberculosis but in whom symptoms and clinical observations were either absent or not at all typical of this disease as it occurs in the practice of any urologist. This apparent difference in types of cases aroused the interest of my colleagues and myself and caused us to continue our clinical investigation. When I studied the patient's condition during
Prenatal diagnosis of Down's syndrome
Authors: N. Fost
Journal: JAMA (1979)

There are now sufficient data on the safety and accuracy of prenatal diagnosis of Down's syndrome to state that the procedure is no longer experimental and can be considered standard care for women in specified risk groups.<sup>1</sup>A court in New York state recently concluded that a physician may be considered negligent for not advising a 37-year-old pregnant woman of these facts.<sup>2</sup>These realities will undoubtedly stimulate a rapid increase in demand for the procedure, especially since use of such services is now less than 5% among women who are at clearly increased risk.<sup>1</sup> There will continue to be disagreement about some of the ethical issues at stake, particularly regarding abortion and the eugenic implications of labeling a genetically distinct group of persons as inferior. While consensus on these matters cannot be expected in the foreseeable future, there are other ethical and social issues about which most
Bundle branch block.
Journal: BMJ (1970)

very fully the risks of oral contraceptives.But the conclusion they draw is unanimous.The risks of systemic contraceptives are much less than the risks of pregnancy.The alternatives to oral contraceptives have, on the average, a higher failure rate and carry other disadvantages.The most reasonable conclusion, therefore, is that practitioners should weigh the pros and cons of different methods for each indi- vidual patient.Steroidal contraceptives are still the right
Correction: RPS27L Modulates DNA Damage Response
Journal: Cancer Research (2008)

In the article on how RPS27L modulates DNA damage response in the December 1, 2007 issue of Cancer Research (1), the primer sequences for reverse transcription-PCR analysis on page 11318 should read as follows: RPS27L, 5 ¶-ATGCCTTTGGCTAGAGATTT-3 ¶( forward) and 5 ¶-GCAACCTGGACATTTTACAT-3 ¶(reverse); RPS27, 5 ¶-GTGACGACCTACGCACACGA-3 ¶ ( forward) and 5 ¶-GTG-CTGCTTCCTCCTGAAGG-3 ¶ (reverse).On page 11319, the siRNA sequence for RPS27L should read as follows: 5 ¶-GGCTAGAGATT-TACTACAT-3 ¶.Two additional siRNA against RPS27L should read as follows: 5 ¶-CATGCCTTTGGCTAGAGAT-3 ¶ and 5 ¶-TGTCCAGGT-TGCTACAAGA-3 ¶.The sequence of reverse primer for RPS27L cloning on page 11319 should read as follows: 5 ¶-GAATTCCAGTG-TTGCTTTCTTCTAAATGA-3 ¶.
Intermediary Metabolism of the Lung
Authors: Aron B. Fisher
Journal: Environmental Health Perspectives (1984)

The lung is a metabolically active organ that is engaged in secretion, clearance and other maintenance functions that require reducing potential, energy and substrates for biosynthesis. These metabolic requirements are met in part through uptake and catabolism of glucose which represents the major fuel utilized by lung tissues. Gluconeogenesis does not occur, and glycogen stores are limited so that the lung depends on the circulation for its glucose requirement. Other substrates can be metabolized by lung and contribute to the metabolic pool although their role has been less thoroughly studied. Glucose is catabolized in the lung by cytoplasmic and mitochondrial pathways that are responsive to regulatory mechanisms as in other tissues. Activity of the pentose cycle pathway of glucose catabolism is relatively high and generates the NADPH required for biosynthesis of lipid, detoxification reactions, and protection against oxidant stress. The ATP content of the lung is maintained by oxidative metabolism at levels comparable to other metabolically active organs. Alterations in lung intermediary metabolism may depress amine clearance, alter lung permeability, and influence the lung response to oxidant stress.
How achievable is immediate ART for all?
Authors: None The Lancet HIV
Journal: The Lancet HIV (2015)

The presentation of results from the Strategic Timing of Antiretroviral Treatment (START) trial was undoubtedly one of the main events of the recent International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention in Vancouver (July 19–22). The trial, published in the New England Journal of Medicine compared immediate treatment on HIV diagnosis with treatment delayed to the former WHO recommended immunological tipping point—a CD4 count of 350 cells per μL. The study results suggested that for the best health outcomes, people with HIV should start treatment as soon as possible rather than waiting for effects of the virus to become apparent.
AB0182 Alternatively Activated Dendritic Cells Derived from Systemic Lupus Erythematosus Patients Have Tolerogenic Phenotype and Function
Authors: H.J. Wu, Y. Lo, D. Luk, C.S. Lau, M.Y. Mok
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Generation of tolerogenic dendritic cells (DCs) has been extensively studied using cytokine, growth factor, genetic engineering and pharmacological methods. Tolerogenic DCs are increasingly explored as cell-based therapy in murine model of autoimmune diseases and may have potential therapeutic implications in the treatment of systemic lupus erythematosus (SLE) that is characterised by dysregulated innate and adaptive immune responses. <h3>Objectives</h3> In this study, we generated alternatively activated DCs (aaDCs) from SLE patients and healthy subjects and examined their immunoregulatory properties <i>in vitro</i>. <h3>Methods</h3> aaDCs were generated by treating monocyte-derived DCs by combination of 1,25 dihydroxyvitamin D(3) (vitD3) and dexamethasone followed by lipopolysaccharide-induced maturation <h3>Results</h3> Lupus aaDCs were found to acquire semi-mature phenotype that remained resistant to immunostimulatory effect of sCD40L, CpG-DNA and SLE serum. These cells produced low level of IL-12 but high level of IL-10. They had attenuated allostimulatory effect on T cell activation and proliferation comparable to normal aaDCs and demonstrated differential immunomodulatory effects on naïve and memory T cells. These aaDCs were capable of inducing IL-10 producing regulatory T effectors from naïve T cells whereas they modulated cytokine profile with suppressed production of IFN-γ and IL-17 by co-cultured memory T cells with attenuated proliferation. The tolerogenicity of aaDCs was shown to be superior than those generated using vitD3 alone in lupus patients. aaDCs expressed lower level of RelB but apoptosis of DCs and IL12/IL-10 imbalance were not found to account for their tolerogenicity. <h3>Conclusions</h3> Our data suggested that combination of vitD3 and dexamethasone represented a feasible method in the generation of tolerogenic DCs from SLE patients. <h3>Disclosure of Interest</h3> None declared
Changing values for the normal thyroid radioactive iodine uptake test
Authors: E. T. Wong
Journal: JAMA (1977)

The normal range for thyroid radioactive iodine (RAI) uptake values in the Minneapolis area has shifted twice in the past 20 years. The mean 24hour thyroid RAI uptake value in 29 normal subjects was 20.5%±6.1% (SD) in 1975, whereas only four years previously it was found to be 11.5%±4.4% (SD) in 51 normal subjects. In a previously published study, the mean thyroid RAI uptake value in normal subjects in this area was 25%±8% (SD) in 1957. The iodine content of commercially baked white bread currently available in this area was found to average only 26 μg per single slice of bread; the change in the mean 24-hour thyroid RAI uptake value that we observed between 1971 and 1975 is most likely due to a marked reduction in this source of dietary iodine. (<i>JAMA</i>238:1741-1743, 1977)
Hippocrates Unbound
Authors: Steven Fox
Journal: JAMA (1984)

Working in a Beijing hospital for two years (1979 to 1981), I witnessed a metamorphosis of medical education in China. Walls have been whitewashed to mask discredited slogans of the past. Dining halls have been stratified to separate faculty, workers, and students. Since 1976, the academic program has doubled in length. Since 1979, revitalized basic science departments have enrolled postgraduates. "Worker-peasant-soldier" graduates of 1975 to 1980 have been recalled for remedial courses. Physicians from outlying provinces now staff city hospitals for terms of "advanced study." Barefoot doctors, highly regarded five years ago (but now considered to be only temporary expedients), face proficiency examinations. Doctors with shoes are also newly concerned about professional standards. Since 1977, prospective medical students take a nationwide entrance examination. Medical colleges now maintain transcripts and confer degrees. House staff, graduates of as long ago as 1964, are preparing for board examinations. Educational policy since 1977 is a determined reversal of trends of the preceding ten years. (<i>JAMA</i>1984;251:490-494)
HOUT-23. SEIZURES IN GRADE III GLIOMAS: NATURAL HISTORY AND RESPONSE TO TREATMENTS
Authors: Roberta Rudà, Francesco Bruno, Francesca Mo, Alessia Pellerino, Carlotta Chiavazza, Federica Franchino, Riccardo Soffietti
Journal: Neuro-Oncology (2017)

There is lack of studies focused specifically on seizures in grade III gliomas in the MRI and molecular genetics era. The aim of this retrospective study was to describe the natural history and response to treatments of seizures in a cohort of grade III gliomas taking into account the molecular markers. We retrieved from our institutional database all patients with grade III astrocytoma, oligodendroglioma and oligoastrocytoma according to WHO 2007 with at least one seizure in the disease course, who were followed between 1995 and 2015. We evaluated seizure type, frequency, and control after surgery, radiotherapy, chemotherapy and chemoradiation. We found 133 patients with grade III glioma of whom 91 de novo and 42 from previous grade II tumors. Overall, seizures were the presenting symptom in 88% of patients, while occurring later in 12%, and were simple partial (54%), partial complex (13%) and secondary generalized (19%). Seizure frequency was ≥ 1/day in 5% patients, and tumors with IDH1/2 mutations showed a higher seizure frequency (≥ 1 seizure/day in 9%) than grade III IDH1 wild-type (≥ 1 seizure/day in 0%). After surgery 70% of patients were seizure free, and a seizure reduction ≥50% was observed in 61% following radiotherapy, 52.4% following TMZ or PCV, and 38% following chemoradiation. Patients with both IDH1/2 mutations and 1p19q codeletion showed a better seizure reduction (71% after radiotherapy and 64% after chemotherapy) than those with IDH1/2 wild type (60% after radiotherapy and 38% after chemotherapy, p˃0.01). This study confirms the high epileptogenicity of grade III gliomas, and suggests that adjuvant antineoplastic treatments may favorably impact seizure control. To our knowledge, this is the first study reporting that IDH1/2 mutated grade III gliomas have a higher seizure frequency but a better seizure control after antineoplastic treatments than IDH1 wild-type tumors.
Estimating Cancer Risks to a Population
Authors: Marvin A. Schneiderman, Charles C. Brown
Journal: Environmental Health Perspectives (1978)

Three important issues impinge on estimating the risk of cancer to a population: (1) How can one use epidemiologic studies on one population to tell us what is likely to happen to other populations? (2) How can one use nonhuman data (i.e., laboratory experiments) to tell us what is likely to happen to humans? (3) What reasonable assumptions can be used to guide the logical extension of information from the laboratory to expectations for man, and what research is needed to support or modify these assumptions? Four principles currently guide our laboratory-to-man extrapolations: effects in animals, properly qualified, are applicable to man; methods do not now exist to establish a threshold for long-delayed effects such as cancer; the exposure of experimental animals to high doses is a necessary and valid method of discovering possible carcinogenic hazards in man; materials should be assessed in terms of human risk rather than as "safe" or "unsafe".
Computer Used to Prescribe Psychiatric Drugs
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cord compression and lung cancer.
Journal: BMJ (1991)

increased in diabetic subjects."9Non-insulin dependent diabetics have an increased risk of cardiovascular disease'0 even when a correction is made for recognised cardiovascular risk factors."An excess cardiovascular risk may also be associated with impaired glucose tolerance.'2The prevalence of non-insulin dependent diabetes and impaired glucose tolerance may vary between populations but a combined prevalence of over 60% is reported for a Scandinavian population of men aged between 65-84.'3A similar prevalence of glucose intolerance in the study population would undoubtedly result in an increased number of deaths from cardiovascular and non-cardio- vascular causes.An underestimate of diabetes as a cause of death in this population may be available from the Swedish mortality register.The observation of the relation of serum sialic acid and mortality is of undoubted interest but warrants further detailed investigation before serum sialic acid concentration is accorded the status of a risk factor or predictor of mortality.
Plastic Surgery
Authors: Thomas J. Krizek
Journal: JAMA (1984)

The term "plastic surgery" is derived from the Greek<i>plastikos</i>and therefore carries in its name the concept of shape and form. It has been in these specific areas, shape and form, that the most important strides have been made in the last year. Suction lipoplasty has evolved from a surgical oddity into an important facet of patient treatment; tissue expansion has moved from being a simple biologic observation into a useful clinical tool; and finally, the exciting tissue-transferring techniques of microsurgery and musculocutaneous flaps introduced in previous decades have moved toward refinement. Suction KJuction lipoplasty (suctionassisted lipectomy or suctionassisted lipolysis) is exactly what the name implies: the contouring of a body part by the removal of fatty tissue by suction, usually without traditional incisional or excisional surgery. Used with success by Teimourian and Fisher<sup>1</sup>for a number of years, the procedures have recently received considerable exposure in France,
Corrigendum
Journal: Allergy (2004)

In (1), the following error was published on page 1271, in the last line of the first paragraph in the Endpoints section.The primary and secondary endpoints showed significant improvement with montelukast relative to placebo over the entire 4 weeks of treatment (P ¼ 0.006 for all primary and secondary endpoints; Table 3).The text was wrong and should have read:The primary and secondary endpoints showed significant improvement with montelukast relative to placebo over the entire 4 weeks of treatment (P £ 0.006 for all primary and secondary endpoints; Table 3).
Association between oncologists’ dispositional affect and depressive symptoms in their patients with metastatic cancer.
Authors: William F. Pirl, Jennifer Lerner, Justin Eusebio, Lara Traeger, Lauren Fields, Areej El-Jawahri, Joseph A. Greer, Jennifer S. Temel
Journal: Journal of Clinical Oncology (2015)

214 Background: While caring for patients with metastatic cancer can be emotional, relationships between the emotions of oncologists and their patients have not been examined. As patients and oncologists read emotional cues in encounters, emotions of one or both may impact the other. We explored associations between dispositional affect, tendencies to emotionally respond to situations in certain ways, in oncologists and depressive symptoms in their patients with newly diagnosed metastatic lung and gastrointestinal (GI) cancers. Methods: As part of an ongoing trial of early palliative care, participants were assessed at baseline for depressive symptoms (Patient Health Questionnaire-9, PHQ9) within 8 weeks of diagnosis with metastatic lung and GI cancers. Oncologists providing care for these patients completed the Positive and Negative Affect Scale (PANAS), a validated measure of dispositional affect with positive and negative dimensions. Associations between patient depressive symptoms and oncologists' positive and negative dispositional affect were tested with linear regression models. Results: Sixteen of the 18 oncologists with patients in the trial completed the PANAS. Among 323 participants with baseline assessments, 277 (86%) had oncologists who completed the PANAS. Mean age=64.6, 129 (46%) were female, 159 (57%) had GI and 118 (43%) lung cancer, and mean PHQ9 score=6.5. Positive and negative dispositional affect were not associated with oncologists’ sex, years from training, hours in clinic, and cancer specialization. Patient depressive symptoms were significantly higher if their oncologists reported greater negative dispositional affect (p=.04). The relationship remained significant adjusting for patient age, sex, cancer type, ECOG PS, smoking, and number of oncology visits (β=.13, t=2.1, p=.04). PHQ9 scores were not associated with oncologists’ positive dispositional affect. Conclusions: Depressive symptoms in patients with metastatic lung and GI cancers appear to be associated with their oncologists’ negative dispositional affect. Determining the direction of the association may lead to new ways of improving patients and/or oncologists moods.
Pyoderma gangrenosum.
Authors: T Takvorian, A Skarin, R Johnson
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.1.407 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8996168 Pyoderma gangrenosum. T TakvorianxT TakvorianSearch for articles by this author , A SkarinxA SkarinSearch for articles by this author , R JohnsonxR JohnsonSearch for articles by this author Show More Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. https://doi.org/10.1200/JCO.1997.15.1.407 PDF "Pyoderma gangrenosum.." Journal of Clinical Oncology, 15(1), p. 407© 1997 by American Society of Clinical Oncology