tbuckley/cabot-search huggingface dataset:
Abstract 1743: Stem/Progenitor Markers Sca-1 versus C-kit and CD31 Determine Angiogenic Potential of Mouse Bone Marrow-derived Endothelial Progenitor Cells
Authors: Toshikazu D Tanaka, Masaaki Ii, Haruki Sekiguchi, Kentaro Jujo, Sol Misener, Douglas W Losordo
Journal: Circulation (2008)

Background: Endothelial progenitor cells (EPCs) have been shown to have angiogenic potential contributing to neovascularization. However, the definition of EPC, including surface marker expression of EPCs promoting vasculo-/angiogenesis in ischemic tissue, remains uncertain. We hypothesized that stem/progenitor (c-kit vs. sca-1) and endothelial cell (EC) markers (CD31) may identify cells with enhanced EPC potential. Methods and Results: Mononuclear cells (MNCs) were isolated from mouse bones, and Lin+ cells were depleted by magnetic cell sorting. Lin- cells were further sorted with the following markers (% of total MNCs) by FACS: c-kit+ (1.87%), sca-1+ (0.6%), c-kit+ /CD31+ (1.1%) and sca-1+ /CD31+ (0.28%). Non-sorted MNCs were used as a control. To examine EC phenotype in culture, cells were labeled with DiI and co-cultured with mature ECs (human microvascular endothelial cells: HMVECs). The percent incorporation of DiI labeled cells into HMVEC tube structures 12 hours after co-culture and BS1-lectin positivity/acLDL uptake were: sca-1+ /CD31+ cells (87 ± 2%) &gt; c-kit+ /CD31+ (79 ± 8%) &gt; sca-1+ (62 ± 8%) &gt; c-kit+ (59 ± 5%) &gt; MNC (50 ± 3% ) . Next, we examined homing capacity of these cells to ischemic myocardium using a mouse myocardial infarction (MI) model. DiI-labeled cells (5x10 4 , IV) were injected to splenectomized mice 3 days after MI, and the hearts were excised 24 hours after the cell injection for histological analysis. Interestingly, the number of recruited/retained DiI-labeled-cells in the MI hearts exactly replicated the findings of the in vitro tube formation assay (cells/HPF): sca-1+ /CD31+ (108 ± 26) &gt; c-kit+ /CD31+ (77 ± 16) &gt; sca-1+ (71 ± 14) &gt; c-kit+ (67 ± 1) &gt; MNCs (48 ± 6) , suggesting that sca-1+ /CD31+ cells might have great functional activities as endothelial precursors. Conclusions: Both stem/progenitor marker Sca-1 and EC marker CD31 expressing EPCs exhibited high potential angiogenic capacity with EC phenotypic features compared with c-kit expressing cells. Our data suggest that Sca-1+ /CD31+ cells may represent EPC-rich cell population, and Sca-1/CD31 could be useful markers to enrich for cells with EPC potential. Ongoing studies will determine the in vivo characteristics of these cells for ischemic tissue repair.
Massachusetts Medical Society
Authors: Marshall A. Lamb
Journal: New England Journal of Medicine (1956)

TOXIC HAZARDS*Lead Poisoning Still Occurs†Although lead poisoning is not now as prevalent as during the first quarter of the century, it is by no means a rare disease. Its occurrence among painters has been greatly reduced by the substitution of titanium oxide pigment for white lead in inside paints. Lead pigments are still used in outside paints, however, and especially as a priming coat for structural steel. The recent boom in road construction in New England has been accompanied by a few cases of lead poisoning among the men engaged in painting the structural steel required for bridges . . .
Current cancer concepts. Adrenalectomy as palliative treatment
Authors: C. B. Huggins
Journal: JAMA (1967)

It is certain that removal of both adrenal glands of patients with widely disseminated mammary carcinoma can result in prompt, profound, and longlasting regression of the cancer. Consequently, bilateral adrenalectomy can be useful therapy in cancer. Regression of mammary cancer following removal of glands that produce growth-promoting steroids (ovary, testis, adrenal) depends on (1) hormone dependence of the tumor and (2) hormone production by the host. Adrenalectomy has little or no beneficial effect in patients with hormone-independent cancer. The earliest indication that advanced cancer of any sort can be induced to regress was the beneficial effect of oophorectomy on mammary cancer in women discovered by Beatson.<sup>6,7</sup>But why does cancer of the breast sometimes thrive in women deprived of ovarian function by oophorectomy or the menopause? Many theoretical considerations<sup>8</sup>have enabled us to identify the adrenal glands as factors in sustaining the presence of mammary cancer in man.
Disease in Milk.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A significant infarct related stenosis after successful thrombolysis: Not associated with adverse clinical outcome but a strong predictor of reocclusion Peter C. Kievit, Marc A. Brouwer, Gerrit Veen, Johan Karreman, Freek W. A. Verheugt. Heartcenter, University Medical Center, Nijmegen, The Netherlands, Free University Hospital, Amsterdam, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
Measurement of red blood cell life-span
Authors: R. P. Brouillard
Journal: JAMA (1974)

The life-span of the red blood cell (RBC) is difficult to estimate clinically, as hemolysis may exist in the presence of normal levels of hemoglobin and bilirubin, as well as normal reticulocyte counts. Clinically useful methods for quantification of the RBC life-span include isotope methods and measurement of endogenous carbon monoxide production. Chromium 51 is the isotope most widely used but has the disadvantage of requiring blood sampling for 30 days. Measurement of endogenous carbon monoxide production has the advantage of sensitivity to low-grade hemolysis and requires only three hours of the patient's time. It is potentially useful for demonstrating changing levels of hemolysis related to drug therapy or autoimmune states. (<i>JAMA</i>230:1304-1305, 1974)
Pedophilia
Authors: Michael C. Seto
Journal: Annual Review of Clinical Psychology (2009)

Pedophilia is defined as a sexual interest in prepubescent children. It is empirically linked with sexual offending against children: Child pornography offenders and sex offenders with child victims are more likely to be pedophiles based on self-report or objective measures of sexual interests. At the same time, some pedophiles have not had any known sexual contact with children, and perhaps half of sex offenders against children would not meet diagnostic criteria for pedophilia. Pedophilia can be diagnosed using a variety of methods and is an important factor to consider in the assessment of sex offenders because pedophilic offenders are more likely to sexually reoffend and require different interventions. There is no evidence to suggest that pedophilia can be changed. Instead, interventions are designed to increase voluntary control over sexual arousal, reduce sex drive, or teach self-management skills to individuals who are motivated to avoid acting upon their sexual interests.
SP0183 2016 Update of The EULAR Recommendations for The Management of Early Arthritis
Authors: B. Combe
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Objectives</h3> In 2007 the EULAR recommendations for the management of early arthritis have been published. In 2010 EULAR also published recommendations for the management of rheumatoid arthritis (RA) with synthetic and biological DMARDs, which were updated in 2013. These later recommendations focussed on the generic pharmacological treatment of RA including Early RA, whereas the 2007 recommendations on early arthritis covered the entire spectrum of the management of early arthritis including also recognition of arthritis, referral, diagnosis, prognosis, classification, information, education, non-pharmacological interventions, and monitoring of the disease process. Between January 2005, when the systematic literature research (SLR) was performed to develop the 2007 recommendations, and 2015 an abundant and rich literature has been published in the field of early arthritis. Taken these points together, it seems important to currently update the EULAR recommendations on early arthritis management. <h3>Methods</h3> In accordance with 2014 EULAR Standardised Operating Procedures, the task force pursued an evidence-based approach and an approach based on expert opinion. The task force involved 20 rheumatologists, two patients and one health professional representing 12 European countries. One of them (RL) served as an epidemiologist in order to control the scientific content of the process. The group defined the focus of the task force, the target population, formulated an operational definition of "management" and selected the research questions. A SLR was performed by two fellows (CD, CH) with the help of skilled librarian. A set of draft recommendations was proposed on the basis of the research questions and the results of the literature search. For each recommendation the categories of evidence were clearly identified then the strength of the recommendation was derived and level of agreement was determined after voting process. <h3>Results</h3> Fifteen research questions, covering the entire spectrum of "management of early arthritis" were formulated. The updated recommendations comprise 3 overarching principles and 12 recommendations for the management of early arthritis. The selected statements included recognition of arthritis, referral, diagnosis, prognostication, imaging, classification, treatment of early arthritis (information, education, non pharmacological interventions, pharmacological treatments, and monitoring of the disease process) as well as strategy. The strength of each recommendation was provided. On the basis of expert opinion, 10 items were identified as being important for future research. <h3>Conclusion</h3> These recommendations provide Rheumatologists, General Practitioners, Health professionals, Patients, and other stakeholders with an updated EULAR consensus on the management of patients with early arthritis <h3>Disclosure of Interest</h3> None declared
Mother and Child.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UNITED KINGDOM
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PWE-085 Analysis of the clonality of Barrett's oesophagus glands reveals they are clonal and establishes a common stem cell for glandular and squamous epithelium
Authors: A M Nicholson, T A Graham, A I Simpson, A Humphries, N A Wright, S A C McDonald, J A Jankowski
Journal: Gut (2010)

<h3>Introduction</h3> Barrett9s oesophagus (BE) describes the change from the normal keratinised squamous epithelium of the oesophagus into an intestinal columner phenotype. BE is the only known precursor of oesophageal adenocarcinoma. Little is known about the origin and stem cell architecture of BE glands, or about the mechanism of gland spread. Here we have used non-pathologic mitochondrial DNA (mtDNA) mutations as a marker of clonal expansion to investigate the origin and spread of clones within BE. <h3>Methods</h3> Enzyme histochemistry for cytochrome-c oxidase (CCO) and succinate dehydrogenase (SDH) was performed on frozen sections of BE. Laser-capture microdissected cells were taken from glandular and squamous epithelium. Mutations were indentified using a nested PCR protocol and sequencing of the entire mtDNA. <h3>Results</h3> CCO deficient glands, were seen in sections of a gastric type BE (n=2/2), but not within intestinal metaplasia (n=3/3). Where CCO deficient glands were seen all cells contained the same mutation, suggesting a common stem cell origin. Mixed glands containing CCO positive and negative lineages were observed suggesting multiple stem cells may be present in the one gland. Patches of adjacent glands varying between 2-7 glands containing the same mutation were seen, indicating that BE glands spread by fission. In one case, cells from CCO deficient squamous tissue shared the same mtDNA mutation as cells from underlying CCO deficient glandular epithelium, suggesting the two tissue compartments are derived from a common progenitor cell <h3>Conclusion</h3> mtDNA mutation burden differs between histological subtype of BE, perhaps reflecting in part the differing epigenetic stimuli from the environment such as acid and bile, as well as the histological organisation and topography of the stem cell gland unit. Patches of adjacent glands can share the same mtDNA mutation, indicating that glands spread by fission. Finally we have shown the both glandular and squamous tissue can be derived from a common progenitor cell. Taken together these findings indicate that distinct oesophageal lineages may be topographically and developmentally interconnected making eradication of some oesophageal squamous lineages necessary in the prevention of EA.
Severe Lactose Intolerance in Infancy
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Protecció a la dona grávida.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculosis and the Increased Death Risk in Mental Hospitals
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: J. L. NEUN
Journal: JNCI Journal of the National Cancer Institute (1991)

BOOK REVIEWS Get access Cancer Nursing: Principles and Practice, 2nd ed. Susan L. Groenwald , Margaret Hansen Frogge , Michelle Goodman , Connie Henke Yarbro eds. Boston : Jones and Bartlett , 1990 , 1348 pp. $125. JACQUELINE L. NEUN JACQUELINE L. NEUN Park Medical Associates 611 Park Ave Baltimore, MD 21201 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 9, 1 May 1991, Page 645, https://doi.org/10.1093/jnci/83.9.645 Published: 01 May 1991
Zeitschrift für Kinderheilkunde, Berlin
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minimally Invasive
Authors: Maria A. Basile
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal