tbuckley/cabot-search huggingface dataset:
OBITUARY
Authors: OMAR M. WILSON
Journal: British Journal of Dermatology (1933)

Journal Article OBITUARY Get access OMAR M. WILSON OMAR M. WILSON Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 12, 1 December 1933, Page 527, https://doi.org/10.1111/j.1365-2133.1933.tb10136.x Published: 01 December 1933
Radiology Quiz
Authors: Barry Kelly, Ian C Bickle
Journal: BMJ (2001)

This 38 year old woman presented at her local accident and emergency department complaining of severe pain on the right side of her chest. The pain started earlier in the day after she had a dizzy spell and fell, hitting a piece of furniture on the way down. The pain was worse on inspiration and on movement. On examination the lower, anterior ribs on the right were tender to palpation, she was in obvious distress, and the nurse reported that her respiratory rate was18, with a SpO2 of 95% on room air. An x ray examination was taken of her chest and the result is shown here.
Hemopexin
Authors: Ursula Muller-Eberhard
Journal: New England Journal of Medicine (1970)

ACUTE, hemolytic episodes have long been recognized as a frequent cause of renal failure.1 , 2 Nevertheless, although most details of the biosynthetic pathway for heme and hemoglobin3 4 5 6 7 are known, the mechanism of hemoglobin degradation8 9 10 11 12 remains largely unexplored.During intravascular hemolysis, hemoglobin is released into the plasma, and both hemoglobin and heme may be detected in the circulation.13 Plasma contains three hemoglobin-binding or heme-binding proteins: haptoglobin, albumin and hemopexin. Haptoglobin14 binds hemoglobin but not heme; albumin15 and hemopexin13 bind the free heme† but not hemoglobin.The serums of patients who have suffered intravascular hemolysis invariably lack haptoglobin16 , 17 because the hemoglobin-haptoglobin complex is . . .
Epididymo-orchitis
Authors: A. Stewart, S. S. Ubee, H. Davies
Journal: BMJ (2011)

A 22 year old student presents with a three day history of painful swollen left scrotum. He has also noticed a burning sensation when he passes urine. There are three main diagnoses to consider in this patient. Epididymo-orchitis is the commonest cause of acute scrotal pain and refers to inflammation of the epididymis and testis. However, the most important differential diagnosis that should be excluded is testicular torsion; this is a surgical emergency where prompt intervention is required. Trauma is an important diagnosis to think about in all patients and is usually suggested by the history. Two much rarer causes of acute scrotal pain and/or swelling include a rapidly growing testicular tumour, which in most cases will present as a painless testicular lump. Idiopathic scrotal oedema usually presents in childhood with bilateral oedema and bruising over the scrotal skin. The testes should not be tender on examination. ### Taking history
Type 2 Diabetes
Authors: David S.H. Bell
Journal: Annals of Internal Medicine (2015)

Letters18 August 2015Type 2 DiabetesDavid S.H. Bell, MDDavid S.H. Bell, MDFrom Southside Endocrinology, Mountain Brook, Alabama.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5122 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Vijan (1) states that treatment of type 2 diabetes with sulfonylureas and thiazolidinediones in particular causes hypoglycemia and weight gain. Although these agents clearly cause weight gain, only sulfonylureas cause hypoglycemia. Thiazolidinediones cause weight gain through not only better glycemic control, less glycosuria, and preservation of calories but also fluid retention due to the presence of peroxisome proliferator–activated-γ receptors in the distal renal tubule. As a result, loop or thiazide diuretics, which act at more proximal tubular sites, do not cause diuresis or weight loss (2). However, use of such diuretics as eperolone, spironolactone, and amiloride, which ...References1. Vijan S. In the clinic. Type 2 diabetes. Ann Intern Med. 2015;162:ITC1-16. [PMID: 25732301] doi:10.7326/AITC201503030 LinkGoogle Scholar2. Chraïibi A, Renauld S. PPARγ-induced stimulation of amiloride-sensitive sodium current in renal collecting duct principal cells is serum and insulin dependent. Cell Physiol Biochem. 2014;33:581-93. [PMID: 24603133] doi:10.1159/000358636 CrossrefMedlineGoogle Scholar3. Vlckova V, Cornelius V, Kasliwal R, Wilton L, Shakir SA. Hypoglycaemia with oral antidiabetic drugs: results from prescription-event monitoring cohorts of rosiglitazone, pioglitazone, nateglinide and repaglinide. Drug Saf. 2009;32:409-18. [PMID: 19419235] doi:10.2165/00002018-200932050-00004 CrossrefMedlineGoogle Scholar4. Bell DS, Patil HR, O'Keefe JH. Divergent effects of various diabetes drugs on cardiovascular prognosis. Rev Cardiovasc Med. 2013;14:e107-22. [PMID: 24448252] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: David S.H. Bell, MDAffiliations: From Southside Endocrinology, Mountain Brook, Alabama.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0310. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoType 2 Diabetes Sandeep Vijan Type 2 Diabetes Sandeep Vijan Metrics 18 August 2015Volume 163, Issue 4Page: 322KeywordsDisclosureDiureticsDrug therapyDrugsHypoglycemiaInsulinType 2 diabetesWeight gainWeight loss ePublished: 18 August 2015 Issue Published: 18 August 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE SLOWNESS WITH WHICH IMPORTANT MEDICAL DISCOVERIES ARE GENERALLY PUT TO PRACTICAL USE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nifedipine in hypertrophic cardiomyopathy.
Authors: H Pouleur, M F Rousseau
Journal: Circulation (1982)

Influence of Heart Rate and Inhibition of Autonomic Tone on the QT Interval" by Ahnve and Vallin.I Their study confirms observations previously made in man in our laboratory.'Ahnve and Vallin also questioned in their discussion that "both heart rate and adrenergic activity affect the duration of the QT interval, but it is not clear as to what extent these effects are interrelated or whether the heart rate effects are independent of autonomic tone.We demonstrated in intact unanesthesized man and in one patient after cardiac transplantation that intravenous infusion of isoproterenol did not modify the dura- tion of the QT interval independent of its effects on heart rate.3In the patient with the cardiac transplant, the QT interval was markedly short- ened at any given heart rate; however, we did not know whether that could be a normal finding in the denervated human heart.
THE PROTOZOA IN DISEASE.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Israeli scientist receives cancer research award
Authors: B. Merz
Journal: JAMA (1983)

Geneticist Leo Sachs, PhD, whose<i>curriculum vitae</i>lists such disparate accomplishments as the hybridization of tomatoes, the development of amniocentesis, and the reversal of malignancy in certain tumor cell lines, is the recipient of the sixth annual BristolMyers award for Distinguished Achievement in Cancer Research. Sachs, chair of the Department of Genetics, the Weizmann Institute of Science, Rehovot, Israel, received the $50,000 prize at a luncheon in New York City this spring. Sachs was cited for his "landmark discoveries that suggest a possible new approach to cancer treatment—one based not on killing cancer cells, but on actually reversing the malignant process." His discoveries stem from research in the mid1960s indicating that a certain protein in the supernatant fluid of cultures of myeloid precursor cells could induce the formation of granulocytes and macrophages. He subsequently determined that the protein, called "macrophage and granulocyte inducer" (MGI), is secreted by a variety of
Menstruation and Systemic Disease
Authors: Joseph Rogers
Journal: New England Journal of Medicine (1958)

MENSTRUATION is a complex process involving delicate and properly-timed relations between hypothalamus, pituitary gland, ovary and uterine endometrium. It is sometimes forgotten that normal menstrual function relates also to the thyroid and adrenal glands, liver, vascular system, nutritional status and emotional factors. It is the purpose of this paper to review the relation of disorders of menstruation to certain systemic diseases. With the exception of the work of Frank1 and of Rubin and Novak,2 no reviews of similar scope have been presented.General ConsiderationsWater and Electrolyte Balance in the Menstrual CycleAlthough the more prominent effects of estrogen and . . .
Transesophageal echocardiography of the aorta
Authors: D. G. Blanchard
Journal: JAMA (1994)

Transesophageal echocardiography (TEE) has become a widely used imaging technique for evaluating cardiac structure, function, and valvular anatomy. Transesophageal echocardiography has also provided a new perspective on the thoracic aorta, and there is growing evidence that the technique contributes valuable and sometimes unique information about aortic structure and pathology. Recently introduced multiplane transesophageal probes have improved visualization of the proximal and transverse aorta, but few comprehensive discussions of TEE's application in aortic disease exist. Therefore, we have reviewed the published literature and our institutional experience in transesophageal aortic ultrasonography. The available evidence strongly supports the use of TEE in aortic dissection and atherosclerosis and suggests potential utility in additional diseases of the aorta such as aneurysm, ulceration, trauma, and congenital or inherited malformation. (<i>JAMA</i>. 1994;272:546-551)
Except
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Journal summary
Journal: Annals of the Rheumatic Diseases (1990)

1990 has been a particularly momentous year for the world: the upheaval in Eastern Europe, the problems facing Russia, the Gulf crisis, and the drought in Africa only serve to emphasise that.It is particularly poignant that this issue contains a contribution from Kuwait.Health care systems are proving burdensomely expensive to provide however rich the country: how much greater are the problems in the poorer states.Nevertheless, I wish you a happy and prosperous new year to come and perhaps a more settled period. LEADER Autoantibodies and antibacterial antibodiesp %l The concept of antibodies was advanced 100 years ago and this was followed soon after by the realisation that auto- antibodies occur too.These two ideas have fundamentally altered our thinking about disease and its possible deter- minants both infective and otherwise.Our leader this month explores this whole subject in depth. SCIENTIFIC PAPERSAutoantibodies in juvenile chronic arthritis p 968 Antibodies to nuclear antigens were studied both in children with juvenile chronic arthritis and in their first degree relatives.That an autoimmune process is occurring in such children is clear, but is this an inherited feature?This has not been looked at before, but the current study suggests that there is indeed an inherited trend.Juvenile chronic arthritis and fibrinolytic activity p 973 This report from Italy looked at the fibrinolytic activity of children affected with chronic arthritis.Some of them may
Bone scanning in screening for metastatic disease
Authors: J. R. Tiegs
Journal: JAMA (1977)

<h3>In Reply.—</h3> The points that Dr Hirsch raises are ones commonly expressed by physicians who have not had much actual experience with audit. A low number of deficiencies found was cited. It is important to understand the difference between a deficiency and a variation. Variations from established criteria might include such things as a complication that prolonged hospital stay, a justification for surgery that is legitimate but was not included in the original criteria, or a postoperative death that occurred despite good operative and postoperative management. All of these problems are discussed in detail in each audit, and deficiencies are recorded only when care or judgment were not optimal. In our community, more than 97.5% of all surgical procedures are performed by fully trained surgeons who are board-certified in their specialty in most instances, and we certainly expect and hope that deficiencies in care will be kept at a minimum.
Macrophage Lineage Cells in Inflammation: Characterization by Colony-Stimulating Factor-1 (CSF-1) Receptor (c-Fms), ER-MP58, and ER-MP20 (Ly-6C) Expression
Authors: James Chan, Pieter J.M. Leenen, Ivan Bertoncello, Shin-Ichi Nishikawa, John A. Hamilton
Journal: Blood (1998)
Immunohistochemical evidence of disease recurrence after liver transplantation for primary biliary cirrhosis
Authors: J Van de Water, L B Gerson, L D Ferrell, J R Lake, R L Coppel, K P Batts, R H Wiesner, M E Gershwin
Journal: Hepatology (1996)

Whether primary biliary cirrhosis (PBC) recurs after liver transplantation has remained an interesting and controversial issue; rejection, viral hepatitis, and drug effects all may mimic recurrent PBC histologically and biochemically. Furthermore, reliable clinical criteria for PBC recurrence are lacking. In this study, the issue of disease recurrence using a well–characterized monoclonal antibody (MAb), C355.1, that reacts with the immunodominant mitochondrial autoantigen of PBC (pyruvate dehydrogenase complex [PDC–E2]) was addressed. When used in an immunohistochemical assay, C355.1 produces intense apical staining of bile duct epithelium specifically in liver sections of patients with PBC and may be the earliest known marker of PBC. Immunohistochemical and histological analysis of serial liver biopsy specimens of 67 patients pre– and post–orthotopic liver transplantation (OLT), including 38 patients with PBC and 29 non–PBC liver disease controls, was performed. Sections were stained with MAb C355.1 or the control MAb C315 and analyzed to determine whether there was a recurrence of apical reactivity in the bile ducts of the posttransplantation biopsy specimens. The immunohistochemical staining was correlated with the histological findings and serum biochemistries at the time of the biopsy. Our data indicate that a significant number of patients who underwent transplantation for PBC (28 of 38) but not controls (0 of 29) develop a staining pattern of liver bile duct epithelium with MAb C355.1 that is indistinguishable from the pretransplantation pattern. Of the 28 patients with this apical staining pattern, 8 were characterized histologically as possible recurrent PBC, 2 as chronic rejection, 2 as acute rejection, 9 as nonspecific changes, 4 as normal or near normal, and 3 had other histological changes. Only 50% of the patients with apical C355.1 staining had liver enzyme levels suggestive of cholestasis. Thus, there appears to be immunohistochemical evidence that supports the concept of recurrence of PBC after OLT. The appearance of biliary epithelial abnormalities before the clinical appearance of disease is important not only for liver transplantation but also for understanding the natural history of PBC.
Abstract 3096: Does The Extent Of Non Viable Myocardium, As Identified By Delayed Enhancement Cardiac Magnetic Resonance, Preclude Response After Cardiac Resynchronization Therapy?
Authors: C Parsai, N Bunce, G.R Sutherland, A Baltabaeva, B Bijnens, M O’Donnell, J Barros, L Anderson
Journal: Circulation (2007)

Cardiac resynchronisation therapy (CRT) is a recognised treatment for symptomatic left ventricular (LV) failure associated with a broad QRS.It has been suggested that &gt;15% myocardial scarring predicted failure to respond to CRT. To determine if the scar burden is a major determinant in response to CRT, we prospectively studied 50 pts (66± 1 years, ischaemic aetiology 57%) undergoing CRT for standard indications at baseline (NYHA: 3±0.4, EF: 23±0.8%, QRS: 150±7 ms, BNP: 495±461 pmol/l) and 6 months post-CRT. Clinical response was defined by a reduction in NYHA class &gt;1 and in BNP level &gt;30%. Reverse LV remodelling was defined as a reduction in end-systolic volume ≥10%. All patients had an echocardiographic examination, including an assessment of dyssynchrony. Additionally, a Cardiac Magnetic Resonance (CMR) study, with delayed enhancement, was performed in patients without contraindications. Of the 30 patients that had CMR, 23 pts (77%) responded clinically to CRT (reduction in NYHA: 1.6±0.6, reduction in BNP: 34±0.4%) and 19/30 (63%) additionally displayed reverse LV remodelling. Among the clinical responders 8 pts (35% of responders) were found to have extensive full thickness myocardial scarring on CMR (in 7 ±1 segments), predominantly in the anteroseptum and apex (86%). Three of these patients also showed significant echocardiographic reverse remodelling. The mechanism of response to CRT in these patients with extensive infarction was more frequently interventricular resynchronisation (43%) or atrio-ventricular resynchronisation (43%) rather than intra-ventricular resynchronisation (14%).The previously suggested 12 segment dyssynchrony index (DI) would have identified none of these responders with extensive myocardial infarction. The DI identified only 7/23 responders (30%). Conclusion : Even patients with extensive myocardial scar are potential responders to CRT and should not be excluded if they fulfil the standard AHA/ESC criteria for biventricular pacing. Intraventricular resynchronisation is not the only mechanism by which patients respond to CRT and measures of intraventricular dyssynchrony alone are inadequate for identifying potential response
Factors Affecting Longevity of Homograft Valves Used in Right Ventricular Outflow Tract Reconstruction for Congenital Heart Disease
Authors: James S. Tweddell, Andrew N. Pelech, Peter C. Frommelt, Kathleen A. Mussatto, John D. Wyman, Raymond T. Fedderly, Stuart Berger, Michele A. Frommelt, David A. Lewis, David Z. Friedberg, John P. Thomas, Ramesh Sachdeva, S. Bert Litwin
Journal: Circulation (2000)

Background —Few studies have explored the long-term function of cryopreserved homograft valves used for reconstruction of the right ventricular tract (RVOT) in patients with congenital heart disease. Methods and Results —Among 205 patients receiving cryopreserved homografts for reconstruction of the RVOT between November 1985 and April 1999, the outcome of 220 homografts in 183 operative survivors was analyzed. There were 150 pulmonary and 70 aortic homografts used. Median age at implantation was 4.4 years (mean 6.9±7.6 years, range 3 days to 48 years). End points included (1) patient survival, (2) homograft failure (valve explant or late death), and (3) homograft dysfunction (homograft insufficiency or homograft stenosis). Survival was 88% at 10 years. Freedom from homograft failure was 74±4% at 5 years and 54±7% at 10 years. Univariable analysis identified younger age, longer donor warm ischemic time, valve Z value &lt;2, and previous procedure as risk factors for homograft failure and dysfunction. Aortic homograft type and extracardiac operative technique predicted homograft failure but not dysfunction. For patients ≤1 year of age, valve type did not predict failure or dysfunction. Multivariable analysis identified younger age and longer donor warm ischemic time as risk factors for homograft failure and dysfunction, whereas, Z value &lt;2 and aortic valve type predicted homograft valve failure. Conclusions —Homograft valves used for RVOT reconstruction provide effective intermediate palliation with excellent late survival. Factors that adversely affect graft longevity include younger age, longer donor warm ischemic time, smaller homograft size, use of aortic homograft in the older patient, and extracardiac operative technique.