tbuckley/cabot-search huggingface dataset:
PWE-011 Aberrantly glycosylated muc1 as a potential therapeutic target for Barrett's with high grade dysplasia and primary and metastatic oesophageal adenocarcinoma
Authors: M A Butt, H Pye, R J Haidry, D Oukrif, M Rashid, M R Banks, M P Deonarain, M R Novelli, L B Lovat
Journal: Gut (2012)

<h3>Introduction</h3> Patients with Barrett9s (BE) associated oesophageal adenocarcinoma (OA), show strong expression of the mucin MUC1, but binding is not specific to dysplasia or cancer. Aberrant glycosylation of MUC1 (AG-MUC1) accompanies the development of cancer in most epithelial tumours, exposing peptides hidden on normal cells. Humanised antihuman milk-fat globule-1 (Hu-HMFG1) antibody binds one of these regions. This study assesses expression of AG-MUC1 in the squamous-metaplasia-dysplasia-OA sequence, in OA specimens with infiltrated nodes and in cancer cell lines. <h3>Methods</h3> 34 paraffin embedded oesophageal tissue specimens were selected from patients with squamous (n=5), non-dysplastic BE (NDBE; n=3), low grade dysplasia (LGD; n=6), high grade dysplasia (HGD; n=9) and OA (n=11). 11 OA resection specimens with clear margins containing tumour and infiltrated nodes were also stained. Slides were immunostained with Hu-HMFG1 antibody and scored by an expert pathologist. Binding of HuHMFG1 to the cancer cell lines SKOV-3 (ovarian), MCF-7 (breast), OE-19, OE33 (oesophageal) and HT-29 (colon) was examined with flow cytometry using a secondary FITC conjugated antibody and analysed with FloJo. <h3>Results</h3> AG-MUC1 was significantly expressed (&gt;33% positively stained cells) in 22% of HGD and 36% of OA specimens. Non-significant mild staining was seen in NDBE (100%), LGD (33%), HGD (44%) and OA (64%). In 27% of OA and 43% of HGD, adjacent squamous epithelium also stained. In surgically resected OA9s, 45% stained significantly for AG-MUC1 in primary tumour. Of these, 80% stained significantly in related lymph nodes. All OA resection margins were clear of significant staining. On flow cytometry, binding was noted on SKOV-3, MCF-7, OE-19 but not HT-29 or OE-33. <h3>Conclusion</h3> This pilot study demonstrates AG-MUC1 to be upregulated in the BE metaplasia-dysplasia-OA sequence with significant staining limited to HGD and cancer. Although some squamous staining was noted, this was likely a field effect as no significant staining was noted in OA resection margins. In patients with significantly stained primary tumour, most had significant staining in infiltrated lymph nodes. Finally, with flow cytometry we identified the OA cell line, OE-19 expressed AG-MUC1 in preparation for in vitro studies. AG-MUC1 targeting with the antibody Hu-HMFG1 offers a novel strategy to target HGD and OA, including those patients presenting with metastatic disease. <h3>Competing interests</h3> None declared.
Influence of clinical knowledge, organizational context, and practice style on transfusion decision making. Implications for practice change strategies
Authors: S. R. Salem-Schatz
Journal: JAMA (1990)

Evidence shows that blood products, like other health care resources, are often used inappropriately, but the reasons for this have not been well studied. We conducted a face-to-face survey of 122 general surgeons, orthopedic surgeons, and anesthesiologists in three hospitals to evaluate the influence of several clinical and nonclinical factors on transfusion decision making. We found wide-spread deficiencies in physicians' knowledge of transfusion risks and indications. Each transfusion risk was estimated correctly by fewer than half of the physicians surveyed, and only 31% responded correctly to a set of four questions regarding transfusion indications. Attending physicians routinely had lower knowledge scores than did residents, yet they exhibited more confidence in their knowledge. Residents' transfusion decisions, however, were strongly influenced by the desires of their attending physicians, resulting in their ordering potentially inappropriate transfusions. Of the residents surveyed, 61% indicated that they ordered transfusions that they judged unnecessary at least once a month because a more senior physician suggested that they do so. These findings provide insights for the development of strategies to improve transfusion practices, which would address the dual concerns of quality of care and cost containment. (<i>JAMA</i>. 1990;264:471-475)
A Text-Book of the Diseases of the Ear.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns
Authors: W. Edward Visser, Edith C.H. Friesema, Theo J. Visser
Journal: Endocrine Reviews (2010)

The effects of thyroid hormone (TH) on development and metabolism are exerted at the cellular level. Metabolism and action of TH take place intracellularly, which require transport of the hormone across the plasma membrane. This process is mediated by TH transporter proteins. Many TH transporters have been identified at the molecular level, although a few are classified as specific TH transporters, including monocarboxylate transporter (MCT)8, MCT10, and organic anion-transporting polypeptide 1C1. The importance of TH transporters for physiology has been illustrated dramatically by the causative role of MCT8 mutations in males with psychomotor retardation and abnormal serum TH concentrations. Although Mct8 knockout animals have provided insight in the mechanisms underlying parts of the endocrine phenotype, they lack obvious neurological abnormalities. Thus, the pathogenesis of the neurological abnormalities in males with MCT8 mutations is not fully understood. The prospects of identifying other transporters and transporter-based syndromes promise an exciting future in the TH transporter field.
Standard Methods of Clinical Chemistry. Volume I
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of Insulin Secretion by Catecholamines in Pheochromocytoma.
Authors: John A. Colwell
Journal: Annals of Internal Medicine (1969)

s1 May 1969Inhibition of Insulin Secretion by Catecholamines in Pheochromocytoma.John A. Colwell, M.D.John A. Colwell, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1061_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCatecholamine-induced inhibition of pancreatic insulin release is reversed by alpha adrenergic blockade with phentolamine. These observations suggest that the abnormal glucose tolerance and depressed plasma insulin concentrations of subjects with pheochromocytoma may be due to alpha receptor stimulation by catecholamines. Plasma glucose and insulin responses to oral or intravenous glucose were investigated pre- and postoperatively in four patients with pheochromocytoma. In two subjects intravenous glucose tolerance and insulin response were measured before and after alpha adrenergic blockade with phentolamine, preoperatively.Abnormal glucose tolerance tests and blunted plasma insulin response returned to normal in three patients and improved in the fourth... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John A. Colwell, M.D.Affiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1061-1061KeywordsAttentionBlood plasmaCatecholaminesGlucoseGlucose toleranceGlucose tolerance testsInsulinInsulin secretionPheochromocytoma ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Seeing things
Authors: Trisha Greenhalgh
Journal: BMJ (2005)

★★★★ Ever wondered what it's like to be detained in Guantanamo Bay? Seven British volunteers, including several Muslims, were given the chance to find out, courtesy of Channel 4, as part of a week-long series of programmes on torture.Reporting to a specially equipped warehouse, they were ambushed, hooded, kidnapped, shackled, caged, and subjected to a range of Pentagon approved interrogation techniques that included sensory deprivation, "sleep adjustment," religious and sexual humiliation, and severe physical pain.But Torture: The Guantanamo Guidebook was no Big Brother-style reality show.This was a serious attempt to examine the effects of torture on the body and the psyche, and to bring home to viewers the kind of interrogation techniques that are being employed in the US-led so called "war on terror.""Tonight we recreate 48 hours in Guantanamo Bay," announced presenter Jon Snow, better known as the face of Channel 4 News."All the interrogation methods you see have been officially sanctioned by the US government and used to fight the war on terror."Using military manuals and declassified US government documents, Channel 4 had installed cages, interrogation rooms, and surveillance equipment to simulate Guantanamo's conditions and methods.But the volunteers, who had their own clothes torn and cut off and replaced with the trade-
PATHOLOGIC SOLICITUDE
Authors: Theodore Diller
Journal: JAMA (1931)

<h3>To the Editor:</h3> —Recently our resident psychiatrist at St. Francis Hospital, Dr. A. Iberler, referring to a couple of women who had had an interview with him regarding their sister, a patient in the hospital, expressed the opinion that their concern and repeated questions, examinations and reexaminations of us as well as of the nurses and Sisters constituted a pathologic solicitude. The term at once impressed me as exceedingly apt. I propose to use it in future, and I am passing it on to readers ofThe Journal, thinking many of them may feel as I do that it is a worth-while, useful and expressive term. Physicians are pestered by unreasonable, impossible and repeated queries from anxious friends to say nothing of those received from the patient himself. But I am inclined to believe that the psychiatrist probably has in this matter a larger burden to carry than physicians practicing
LIVER FUNCTION TESTS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Environmental Malignant Mesothelioma in Southern Anatolia: A Study of Fifty Cases
Authors: E. Handan Zeren, Derya Gumurdulu, Victor L. Roggli, Ilhan Tuncer, Suzan Zorludemir, Melek Erkisi
Journal: Environmental Health Perspectives (2000)

Malignant mesothelioma is a highly aggressive tumor of the serous membranes, which in humans results from exposure to asbestos and asbestiform fibers. Although occupational malignant mesothelioma is still the most common form of this lesion, naturally contaminated soil can play an important role in the development of environmental malignant mesothelioma in some parts of the world. Fifty cases of malignant mesothelioma (MM) from southern Turkey with no occupational history of asbestos exposure were reviewed regarding pathologic and clinical features. A case of hyaline fibrous plaque of the pleura was also included in this series. Histologically the cases were classified as epithelial (36 cases); sarcomatous (7 cases); and biphasic (7 cases). One of the sarcomatous cases was desmoplastic. Ultrastructural examination of the tumor tissue in three cases revealed long-surface microvilli in epithelial cells. Interstitial cells of the lung in one case showed electron-dense asbestos fibers in the cytoplasm. Mineralogical analyses of the lung tissue in three cases of MM and the case of pleural plaque showed high amounts of asbestos fibers most consistent with tremolite and actinolite. The clinical and pathologic features of our cases support that the environmental inhalation of asbestos is still a major health problem in some parts of Turkey.
Cardiothoracic Surgery
Authors: George J. Magovern
Journal: JAMA (1994)

Cardiothoracic surgery continues to be a dynamic field with new developments arising from a variety of sources. In the last 2 years the necessity for making a major incision for a thoracic operation has been challenged, and in many instances it has been replaced by video-assisted thoracoscopic surgery. This technique uses several small incisions (1 to 2 cm) on the chest wall through which a thoracoscope and endoscopic instruments can be introduced and manipulated. An image is captured on a video monitor by a miniature camera attached to the thoracoscope. The advantages of video-assisted thoracoscopic surgery over thoracotomy are decreased postoperative pain, shorter hospitalization, and faster patient recovery.<sup>1</sup>The technique does require single-lung ventilation with collapse of the ipsilateral lung, and therefore general anesthesia and a double-lumen endotracheal tube are needed. Video-assisted techniques have replaced the standard open thoracotomy approaches for most simple thoracic operations. Procedures that are now
Hypodermoclysis
Authors: Rafael J. Schen
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Dr Gluck (1982; 248:1310) has emphasized the exceptional safety of hypodermoclysis, and he cited in evidence our study of 1,850 subcutaneous infusions in 270 elderly persons.<sup>1</sup>Since our experience now encompasses 4,500 subcutaneous infusions in 634 elderly patients, we can draw further conclusions. The commonest untoward effect was overloading, which caused either subcutaneous edema or heart failure in a total of nine patients. In the five patients with subcutaneous edema, the fluid was mostly in the pelvic and genital regions and rapidly responded to diuretics in four of them; one patient died in renal failure but the death was unconnected with the infusion. Of the four patients with pulmonary edema, two died; however, it is possible that in one of the fatal cases, the cardiac insufficiency occurred spontaneously, since the patient received only one infusion consisting of 1 L of glucose-saline. Local infection was seen only
Practical Medicine Series of Year Books, Comprising Ten Volumes on the Year's Progress in Medicine and Surgery. Issued Monthly. Under the General Editorial Charge of Gustavus P. Head, M.D., Professor of Laryngology and Rhinology, Chicago Post graduate Medical School. Vol. VIII. Materia Medica and Therapeutics, Preventive Medicine. Climatology, Suggestive Therapeutics, Forensic Medicine.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psoriatic Arthritis
Authors: Donald H. Loebl
Journal: JAMA (1979)

Psoriatic arthritis is a recognized clinical entity with a variety of clinical patterns and prognoses. We review the clinical, roentgenographic, pathological, and genetic aspects of the disease, as well as the current concepts in the treatment of psoriatic arthritis. (<i>JAMA</i>242:2447-2451, 1979)
ALCOHOL AND SCHOOL PHYSIOLOGIES.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Observations of the Site-Specific Carcinogenicity of Vinyl Chloride to Humans
Authors: Peter F. Infante
Journal: Environmental Health Perspectives (1981)

A review of epidemiologic studies of workers exposed to vinyl chloride (VC) was conducted. Some of these studies comprised small cohorts and thus were insensitive in the evaluation of carcinogenic response for sites that do not demonstrate a high relative risk. Other larger studies used methodology and design that precluded an interpretation of the results. Such limitations were acknowledged by some authors. Use of restrictive disease rubrics also lead to the submerging of sites that would have demonstrated significant excesses. For example, some investigators analyzed data for liver cancer deaths with the board category of digestive system cancer deaths, while others combined data for CNS cancer deaths with the broad category of "other and unspecified cancer," and most studies analyzed information for lymphatic and hematopoietic system cancer deaths with all data combined. Only four of eight studies reviewed could demonstrate a significant excess of liver cancer among VC-exposed workers--a site confirmed in humans by 1974. In contrast, five of eight studies appear to demonstrate a significant excess of CNS cancer mortality. Workers exposed to VC also demonstrate a significant excess of mortality for lung cancer, while the data for lymphatic and hematopoietic system cancer are suggestive. Interpretation of cancer of the latter systems may have been clarified if investigators had not analyzed their data by broad disease classifications.
The emergency department problem. An overview
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal