tbuckley/cabot-search huggingface dataset:
North American Indian rock art and hallucinogenic drugs
Authors: K. F. Wellmann
Journal: JAMA (1978)

It is proposed that the aboriginal rock paintings in two areas of North America may have been produced by shamans while they were under the influence of hallucinogenic agents derived from plants. The first of these areas is the Chumash and Yokuts Indian region of California, where polychrome paintings show designs similar to those visualized during the trance induced by decoctions of jimsonweed (<i>Datura</i>species). The second area is the lower Pecos River region of Texas, where shamanistic figures display traits considered to be conceptual analogues of the mescal bean (<i>Sophora secundiflora</i>) cult as practiced during historic times by Great Plains Indians. Although the evidence is only circumstantial, the proposed connections between these rock drawings and mind-expanding pharmacologic compounds fit well into the documented relationship that encompasses hallucinogenic drugs and certain movable objects of pre-Columbian American art. (<i>JAMA</i>239:1524-1527, 1978)
International Hepatology
Authors: Shannon S. Glaser, Gianfranco Alpini
Journal: Journal of Hepatology (2010)

After specification of the hepatic endoderm, mammalian liver organogenesis progresses through a series of morphological stages that culminate in the migration of hepatocytes into the underlying mesenchyme to populate the hepatic lobes. Here, we show that in the mouse the transcriptional repressor Tbx3, a member of the Tbox protein family, is required for the transition from a hepatic diverticulum with a pseudo-stratified epithelium to a cell-emergent liver bud. In Tbx3-deficient embryos, proliferation in the hepatic epithelium is severely reduced, hepatoblasts fail to delaminate, and cholangiocyte rather than hepatocyte differentiation occurs. Molecular analyses suggest that the primary function of Tbx3 is to maintain expression of hepatocyte transcription factors, including hepatic nuclear factor 4a (Hnf4a) and CCAAT/enhancer binding protein (C/EBP), alpha (Cebpa), and to repress expression of cholangiocyte transcriptionfactors such as Onecut1 (Hnf6) and Hnf1b.
Upper abdominal calcification in a young man
Authors: K. L. Cohen
Journal: JAMA (1978)

<h3>History</h3> A 17-year-old boy was admitted to the hospital for further evaluation of probable chronic pancreatitis. The patient had been undergoing basic training as a Marine Corps recruit when abdominal pain and malaise developed, lasting three days. Figure 1 is a plain film of the abdomen taken at that time. There was no past history of alcohol abuse or symptoms suggestive of gallbladder disease. The patient had had uncomplicated mumps at the age of 5 years and appendectomy at the age of 9 years. There was no history of abdominal trauma. The only other noteworthy history was prolonged cyanosis at birth requiring observation in an incubator for about one week. There were no apparent neurological sequelae. Findings from the physical examination were entirely within normal limits. Routine blood analysis, including determinations of levels of electrolytes, calcium, amylase, and cholesterol, as well as liver function tests, were normal, as was the
Nitrogen Balance After Thermal Burns
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychodermatology
Authors: Loretta S. Davis
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dose Response for TCDD Promotion of Hepatocarcinogenesis in Rats Initiated with DEN: Histologic, Biochemical, and Cell Proliferation Endpoints
Authors: R. R. Maronpot, Julie F. Foley, K. Takahashi, T. Goldsworthy, G. Clark, A. Tritscher, C. Portier, G. Lucier
Journal: Environmental Health Perspectives (1993)

The present study examines the dose-response relationship for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) promotion of histologic and biochemical parameters by using a two-stage model for hepatocarcinogenesis in female Sprague-Dawley rats initiated with a single intraperitoneal dose of 175 mg of diethylnitrosamine (DEN)/kg body weight at 70 days of age. Starting 2 weeks after initiation, treatment groups of 8-10 rats were given TCDD by gavage in corn oil once every 2 weeks for 30 weeks. Doses were 3.5, 10.7, 35.7, and 125 ng TCDD/kg body weight/day. A significant body weight reduction was present in the noninitiated group that received 125 ng TCDD. Relative liver weight was statistically increased in initiated rats treated with > or = 10.7 ng TCDD and in noninitiated rats treated with > or = 35.7 ng TCDD. Histopathologic evidence of cytotoxicity was dose-related in all TCDD-treated groups. There was a statistically significant dose response in the bromodeoxyuridine (BrdU) S-phase labeling index (LI) in the DEN-initiated rats (p < 0.01) and a marginally significant trend in the saline-treated rats (p = 0.10), but proliferating cell nuclear antigen S-phase LI and growth fraction within altered hepatic foci showed no increase. Among the DEN-initiated groups there was a significant increase in glutathione S-transferase altered hepatic foci stereological parameters in the 125 ng TCDD group. This study demonstrates that dose-response relationships for TCDD's effects on cell proliferation growth of altered hepatic foci are different from previously reported effects on P450 gene expression, indicating that different biological or biochemical responses may exhibit different dose-response relationships.(ABSTRACT TRUNCATED AT 250 WORDS)
A Study of Nephritis and Allied Lesions.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adequate Supply of Physicians Makes Lower Educational Standards Unnecessary
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Diet on the Hepatotoxicity of Polybrominated Biphenyls (FireMaster PB-6)
Authors: J. G. Babish, G. S. Stoewsand, D. J. Lisk
Journal: Environmental Health Perspectives (1978)

The consumption of diets formulated with Cruciferae vegetables, e.g., cauliflower, cabbage, and Brussels sprouts, has been shown to result in a stimulation of the intestinal and hepatic microsomal enzyme systems in rats. This study was designed to determine if this increase in intestinal and hepatic microsomal enzyme activity affected the hepatic response to polybrominated biphenyls (PBB). After three weeks of consuming either a semipurified or 25% cauliflower leaf-supplemented diet (CLD), male Sprague-Dawley rats were maintained for an additional 20 days on their respective diets containing either 0, 1, or 50 ppm PBB. A significant decrease in body weights, but not feed efficiency, was observed over all levels of PBB in animals consuming CLD compared to semipurified diets; consumption of up to 50 ppm of PBB had no effect on body weights with either diet. Relative liver weights (RLW), hepatic aryl hydrocarbon hydroxylase (AHH), N- and O-demethylase, as well as intestinal AHH were all increased in CLD-consuming animals before the addition of PBB. While PBB supplementation alone resulted in increased RLW, hepatic AHH, N- and O-demethylase, microsomal protein, and cytochrome P-450, rats consuming cauliflower diets + PBB had even higher RLW and N- and O-demethylase activity and microsomal protein concentrations. Hepatic PBB residue and total hepatic lipids were significantly reduced in CLD groups receiving 50 ppm PBB. These results suggest that the antitoxic effects of certain vegetables are related to more rapid metabolism and excretion of xenobiotic compounds.
Error in Author’s Name
Authors: Sanjay Pandey, Neelav Sarma
Journal: JAMA Neurology (2016)

However, the patient we described had no movements that could be induced either by cues or by passive movement.Our patient also did not have any evidence of perseveration.Repetitive slow or clonic movement in 4 cases were also reported by Lee and Marsden 3 in a review of 62 cases of movement disorders following thalamic or subthalamic infarct.But the movement appeared after a delay of 3 weeks to 9 months following the stroke, and the authors concluded that the clonic movements might have been epileptic in origin.Stereotypy has been defined as a non-goal-directed movement pattern that is repeated continuously for a period in the same form on multiple occasions and which is typically distractible. 4It can be primary or secondary to some underlying neurological conditions such as developmental delay, paraneoplastic and postinfectious conditions, basal ganglia lesions, and drugs (amphetamines and psychostimulants).5][6] Unlike tics, they are not associated with an internal urge to perform the task and there is no development of internal tension when the patient tries to suppress this movement. 5In our patient, although the severity of the movement varied over time, the pattern remained the same in the form of wrist flexion extension.The movements were also distractible as it used to stop when somebody got very close to him, causing great difficulty in video recording.He was also able to suppress the movements at will, which is clearly seen in the video. 1 On direct questioning, he denied any internal urge or tension when the movements stopped.Based on the discussion here, we would like to differ with Tai and colleagues about the possibility of clonic perseveration in our patient, and we think that stereotypy will be a better phenomenological description.However, we agree that stereotypy and clonic perseveration need to be recognized following basal ganglia or thalamic lesion to avoid misdiagnosis of tremor and seizure.
The Editors' Choice
Authors: D LEUNG, H NELSON, S SZEFLER
Journal: Journal of Allergy and Clinical Immunology (2006)

Corticosteroids and long-acting β-agonists (LABAs) effectively reduce inflammation and bronchoconstriction. However, they are less effective at reversing or preventing remodeling—the structural changes that are a feature of persistent asthma and that include increased smooth muscle mass and extracellular matrix protein deposition. Airway smooth muscle cells are thought to play a key role in the regulation of airway remodeling. In this issue of the Journal, Burgess et al (p 649) have shown that corticosteroids and LABAs had no effect on TGF-β–induced expression of fibronectin in airway smooth muscle cells from asthmatic or nonasthmatic individuals.
Carbenoxolone sodium capsules in the treatment of duodenal ulcer. An endoscopic controlled trial.
Authors: J Sahel, H Sarles, J Delmont, J Dubarry, R Dupuy, R Gisselbrecht, H Monges, A Ribet
Journal: Gut (1977)

Abstract Eighty-six patients with duodenal ulcer were treated in a multicentre controlled trial with carbenoxolone capsules (Duogastrone, 50 mg four times a day for six weeks) or a placebo. Sixty-nine patients accepted endoscopy at the beginning and end of the treatment. Symptomatic responses and endoscopic improvement were significantly greater in those receiving the active preparation than in those receiving the control capsules, complete, endoscopically assessed, healing being achieved in 65% and 20%, respectively, of individuals having accepted endoscopy, after six weeks' treatment. Side-effects of salt and water retention or hypokalaemia were noted in over a quarter of those receiving the carbenoxolone capsules, but none of the adverse effects was severe enough to necessitate withdrawal of treatment.
Vaccinia necrosum following smallpox vaccination for chronic herpetic ulcers
Authors: J. M. Neff
Journal: JAMA (1970)

To our knowledge, there are nine known cases in which vaccinia necrosum has followed smallpox vaccination for chronic herpetic ulcers. In five cases the patients died. One patient who died and one who recovered are reported here. Vaccination has never been shown to be an effective treatment for chronic herpes infection. We believe it should be considered a potentially dangerous practice, and that this form of supposed therapy be discontinued.
The tourniquet test and screening for diabetic retinopathy
Authors: R. Williams
Journal: JAMA (1985)

<h3>In Reply.—</h3> Ms Halford and Dr Weir address the important concept that not all forms of carbohydrate are absorbed equally. They further address the question that a 2.5-oz Hershey chocolate bar containing 39 g of sucrose might not produce the same glycemic response as 20 g of D-glucose. Unfortunately, the article that they quote to show the glycemic response to 25 g of carbohydrate taken as milk chocolate is not readily available. It is, therefore, very difficult to assess or comment on the results of that study. Obviously, the results would depend on the milk chocolate bars ingested, the patient population selected for testing, the insulin response of the patient population selected, and multiple other variables. In addition, we carefully pointed out several of the points alluded to by Ms Halford and Dr Weir. We state in our manuscript that the specific form of carbohydrate may be more important than
Multiple Sclerosis and Poliomyelitis
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neoplastic involvement of granulocytic lineage, not granulocytic‐monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia case report
Authors: Kohsuke Yanagisawa, Hideki Ohminami, Masateru Sato, Kiyonori Takada, Hitoshi Hasegawa, Masaki Yasukawa, Shigeru Fujita
Journal: American Journal of Hematology (1998)

Chronic neutrophilic leukemia (CNL) is a very rare myeloproliferative disorder. To determine the neoplastic origin of CNL, morphological and cytogenetical studies were made of colonies derived from hematopoietic progenitors of a patient with CNL. The patient's hematopoietic progenitors spontaneously formed colonies consisting of mature granulocytes, and cytogenetical study of the colonies indicated chromosome abnormalities identical to those in the patient's bone marrow cells. Analysis of colonies consisting of granulocytes and macrophages, macrophages, or erythrocytes disclosed a normal karyotype. These results demonstrated that the neoplastic process in this patient with CNL originated in hematopoietic progenitors capable of differentiating only into granulocytes, and not granulocytes and monocytes, monocytes, or erythrocytes. Am. J. Hematol. 57:221–224, 1998. © 1998 Wiley-Liss, Inc.
<i>QuickStats:</i> Rate of Emergency Department (ED) Visits,* by Homeless Status† and Geographic Region§ — National Hospital Ambulatory Medical Care Survey, United States, 2015–2018¶
Authors: Loredana Santo, Jill Ashman
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

All regions Northeast Midwest South West No. of visits per 100 persons Region Total visits Visits by homeless persons Visits by nonhomeless persons * Visit rates for the homeless population are based on sets of estimates of the U.S. homeless population, reported by the U.S. Department of Housing and Urban Development, from data collected on a single night in January of each year during 2015-2018.Visit rates for the total population are based on sets of estimates of the U.S. civilian, noninstitutionalized population developed by the U.S. Census Bureau's Population Division and reflect the population as of July 1 of each year during 2015-2018.The nonhomeless population was computed by subtraction.Error bars indicate 95% confidence intervals.† Homeless persons are identified as being homeless or living in a homeless shelter.Nonhomeless persons are identified as having a private residence, living in a nursing home, or having some other living arrangement.Patient residence was missing for 2.3% of ED visits; these records were excluded from the analysis.
Uncommon clinical patterns of <i>Fusarium</i> nail infection: report of three cases
Authors: R. BARAN, A. TOSTI, B.M. PIRACCINI
Journal: British Journal of Dermatology (1997)

Three cases of proximal subungual onychomycosis due to Fusarium oxysporum, including a patient with a fingernail infection. are described. All patients were immunocompetent and presented with acute paronychia associated with proximal or total lekonychia of the affected nails. Nail avulsion followed by topical treatment produced clinical and mycological cure. The literature on Fusarium onychomycosis is discussed. The combination of proximal subungual onychomycosis with subacute or acute paronychia involving fingernails or toenails is highly suggestive of Fusarium sp.
Interaction of Metals during Their Uptake and Accumulation in Rabbit Renal Cortical Slices
Authors: Rodney L. Keith, Sharon J. McGuinness, A. Jay Gandolfi, Timothy P. Lowe, Quan Chen, Quintus Fernando
Journal: Environmental Health Perspectives (1995)

The uptake and accumulation of metals occurs in the kidney, which is a key site for interaction between metal nephrotoxicants.The uptake/accumu- lation and interaction of CdCI2, HgCI2, K2Cr207, and NaAsO2 was examined in precision-cut rabbit renal cortical slices.Slices were incubated with 106 to 10-M of a single metal toxicant or combinations of metal toxicants for 12 hr in DME-F12 media.Slices were blotted and sandwiched between two mylar films stretched across XRF sample cups.Quantitation of the metal in the slices was performed by proton-induced X-ray emis- sion analysis (PIXE).The uptake of the metals was rapid, often reaching a maximum between 3 to 6 hr; the accumulation of Hg was highest, fol- lowed in order by Cd, Cr, and As.When two metals were present together, substantial alterations were observed in the uptake of the metals in the slices.HgCI2 hindered the uptake of K2Cr207, NaAsO2, CdCI2 (in this order), whereas these metals facilitated the uptake of HgCI2.However, a decreased uptake of both metals was often noted after exposure to other combinations of metals.PIXE analysis of metal content in slices is attrac- tive since all elements (atomic number >20) can be determined simultaneously.This information will be particularly useful in studying potential toxic interactions.-