tbuckley/cabot-search huggingface dataset:
Renal trauma
Authors: C. K. Jenkins
Journal: JAMA (1968)

Dr. Kook Sang Oh: This is the first Massachusetts General Hospital admission of a 17-year-old white boy who had been in excellent health until four hours prior to admission when he was kicked in the left flank and developed severe flank pain, nausea, vomiting, and gross hematuria. Physical examination showed nothing unusual except for tenseness in the left upper quadrant without re bound tenderness. Vital signs were within normal limits. Hematocrit reading was 41%, and urinalysis showed microscopic hematuria. Roentgenograms of the chest and abdomen were obtained upon admission. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Weber, what do you think is going on? Dr. Alfred L. Weber: The roentgenogram of the chest shows no evidence of rib fracture, mediastinal widening, pleural effusion, or atelectasis. The lung fields are clear. The roentgenogram of the abdomen shows a slightly dilated transverse colon and several small-bowel loops in the midabdomen and right flank.
Ability to remain abstinent after methadone detoxification. A six-year study
Authors: B. Stimmel
Journal: JAMA (1977)

Three hundred thirty-five persons successfully detoxified from methadone hydrochloride maintenance were followed up for as long as six years to determine their ability to remain abstinent from narcotic use. At the end of the observation period, of the 269 persons located, 35% were narcotic-free, 58% had returned to narcotic use, and 8% were either jailed or deceased. The ability of a person to refrain from narcotic use was found to be highly associated with staff's assessment of progress and duration of methadone maintenance treatment. Relapse to narcotic use occurred regardless of length of abstinence, with 35% of relapses occurring after three or more years. While abstinence after narcotic dependency is possible, it is not a realistic goal for all. Premature detoxification from methadone maintenance is associated with a high recidivism rate to narcotics. (<i>JAMA</i>237:1216-1220, 1977)
Pye's Surgical Handicraft. A Manual of Surgical Manipulations, Minor Surgery and Other Matters Connected with the Work of House Surgeons and Surgical Dressers.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WHO READS?
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent Results of Health Examinations on the General Population in Cadmium-Polluted and Control Areas in Japan
Authors: Itsuzo Shigematsu, Masumi Minowa, Tetsuhiko Yoshida, Koji Miyamoto
Journal: Environmental Health Perspectives (1979)

Health examinations by a revised method aimed at detecting renal tubular dysfunctions more effectively were conducted on the general population aged 50 years and over in cadmium-polluted areas (1826 persons) and control areas (1611 persons) in four prefectures in Japan in 1976. Although detailed analysis of the data is not yet completed, some of the results obtained are described here. The prevalence of glucosuria and low molecular weight proteinuria, frequency of decreased % TRP, and cadmium concentrations in urine are higher in the cadmium-polluted areas than in the controls. Clinically diagnosed cases with tubular dysfunctions seem to follow the same trend as above, though these cases are very few in number and they are limited to the advanced age group. When cadmium concentration in rice is taken as an index, a dose-response relationship is not necessarity explicit in the observations by prefecture. However, suggestive data are obtained in the observation by district in one cadmium-polluted area.
Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1α delivery to the liver
Authors: Thais P. Salazar-Mather, Casey A. Lewis, Christine A. Biron
Journal: Journal of Clinical Investigation (2002)

Macrophage inflammatory protein 1α (MIP-1α, CCL3) is critical for liver NK cell inflammation and delivery of IFN-γ to mediate downstream protective responses against murine cytomegalovirus (MCMV) infections. This system was used to evaluate the upstream contribution of the type 1 IFNs, IFN-α/β, in promotion of MIP-1α production. Mice deficient in IFN-α/β functions, as a result of mutation in the receptor for these cytokines (IFN-α/βR–), were profoundly deficient in MIP-1α expression and accumulation of NK cells and macrophages in the liver and had increased sensitivity to MCMV infection. The cytokines themselves were responsible for the immunoregulatory effects, since administration of recombinant IFN-α (rIFN-α) to immunocompetent mice also induced these changes. IFN-α/β was required for NK cell accumulation during infection, and MIP-1α was required for NK cell accumulation in response to administered rIFN-α. In vivo trafficking assays demonstrated a requirement for IFN-α/βR signaling for leukocyte localization in, and delivery of MIP-1α–producing macrophages to, the liver. These results extend characterization of the cytokine and chemokine cascade required for protection against viral infections in tissues by defining IFN-α/β–dependent mechanisms promoting MIP-1α production and the resulting hepatic accumulation of NK cells.
GRADED LOBOTOMY
Authors: MAGNUS C. PETERSEN, J. GRAFTON LOVE
Journal: American Journal of Psychiatry (1949)

Prefrontal lobotomy is a valuable method in the treatment of certain abnormal mental states when other more conservative modes of treatment have failed to give permanent relief. It holds out hope for many patients who, without the operation, would be hospitalized permanently. Prefrontal lobotomy is indicated for certain carefully selected patients who are suffering from intractable pain whether of organic or functional type when less radical measures fail to give relief. The clinical results were better and the unpleasant sequelae were fewer after the grade 3 than after the grade 4 operation.
First anti-oncogene discovered; linked to the development of retinoblastoma
Authors: B. Merz
Journal: JAMA (1987)

ONCOGENES are no longer the only genes associated with carcinogenesis. The first anti-oncogene has been identified. It is linked to the development of the childhood cancer retinoblastoma, and investigators think that anti-oncogenes may play a role in other cancers as well. Anti-oncogenes, as their name implies, are the inverse of oncogenes. While oncogenes are genes that promote carcinogenesis when they are inappropriately<i>activated</i>, anti-oncogenes are genes that do so when they are inappropriately<i>inactivated</i>. The mechanism of the retinoblastoma anti-oncogene has been described by a team of investigators at the McGill University Faculty of Medicine, Montreal, and Harvard Medical School, Boston. Webster K. Cavenee, PhD, director, Ludwig Cancer Centre, McGill, explained how they determined the gene's function at the recent annual meeting of the American Society for Human Genetics in Philadelphia. Cavenee reported that he and his coworkers built their investigation on a substantial body of knowledge accumulated by several
Still disease in adults. A cause of prolonged undiagnosed fever
Authors: M. S. Fabricant
Journal: JAMA (1973)

Two patients with adult-onset Still disease had a characteristic eruption most prominent during the febrile episodes, splenomegaly, and prolonged fever with temperature elevations to 40.6 C. Extensive investigation excluded other possible causes of fever. One patient partially responded to gold sodium thiomalate therapy. Still disease appears to be distinct from seropositive rheumatoid arthritis.
Camptodactyly. A kindred study
Authors: A. Littman
Journal: JAMA (1968)

Camptodactyly is an autosomal dominant trait occurring in less than 1% of the population. We have studied an involved kindred of 71 persons through seven generations. Penetrance was variable and involvement of the right hand predominated. Prevalence rate decreased with succeeding generations, suggesting "genetic dilution" of a necessary modifier gene. Association with radio-ulnar synostosis was found in two sons of sisters, but orthopedic or biochemical associations were not confirmed, and linkage with peptic ulcer was disestablished.
Agranulocytosis
Authors: J. R. H. Pinkerton
Journal: BMJ (1955)

<h3>Abstract</h3> <h3>Background</h3> Up-to-date SARS-CoV-2 antibody seroprevalence estimates are important for informing public health planning, including priorities for Coronavirus disease 2019 (COVID-19) vaccination programs. We sought to estimate infection- and vaccination-induced SARS-CoV-2 antibody seroprevalence within representative samples of the Kenyan population approximately two years into the COVID-19 pandemic and approximately one year after rollout of the national COVID-19 vaccination program. <h3>Methods</h3> We conducted cross-sectional serosurveys within random, age-stratified samples of Kilifi Health and Demographic Surveillance System (HDSS) and Nairobi Urban HDSS residents. Anti-spike (anti-S) immunoglobulin G (IgG) and anti-nucleoprotein (anti-N) IgG were measured using validated in-house ELISAs. Target-specific Bayesian population-weighted seroprevalence was calculated overall, by sex and by age, with adjustment for test performance as appropriate. Anti-S IgG concentrations were estimated with reference to the WHO International Standard (IS) for anti-SARS-CoV-2 immunoglobulin and their reverse cumulative distributions plotted. <h3>Results</h3> Between February and June 2022, 852 and 851 individuals within the Kilifi HDSS and the Nairobi Urban HDSS, respectively, were sampled. Only 11.0% (95% confidence interval [CI] 9.0-13.3) of all Kilifi HDSS participants and 33.4% (95%CI 30.2-36.6) of all Nairobi Urban HDSS participants had received any doses of COVID-19 vaccine. Population-weighted anti-S IgG seroprevalence was 69.1% (95% credible interval [CrI] 65.8-72.3) within the Kilifi HDSS and 88.5% (95%CrI 86.1-90.6) within the Nairobi Urban HDSS. Among COVID-unvaccinated residents of the Kilifi HDSS and Nairobi Urban HDSS, it was 66.7% (95%CrI 63.3-70.0) and 85.3% (95%CrI 82.1-88.2), respectively. Population-weighted, test-adjusted anti-N IgG seroprevalence within the Kilifi HDSS was 53.5% (95%CrI 46.5-61.1) and 65.5% (95%CrI 56.0-75.6) within the Nairobi Urban HDSS. The prevalence of anti-N antibodies was similar in vaccinated and unvaccinated subgroups in both HDSS populations. Anti-S IgG concentrations were significantly lower among Kilifi HDSS residents than among Nairobi Urban HDSS residents (p&lt; 0.001). <h3>Conclusions</h3> Approximately, 7 in 10 Kilifi residents and 9 in 10 Nairobi residents were seropositive for anti-S IgG by May 2022 and June 2022, respectively. Given COVID-19 vaccination coverage, anti-S IgG seropositivity among COVID-unvaccinated individuals, and anti-N IgG seroprevalence, population-level anti-S IgG seroprevalence was predominantly derived from infection. Interventions to improve COVID-19 vaccination uptake should be targeted to individuals in rural Kenya who are at high risk of severe COVID-19.
The art of self-mutilation. II. Delusions of parasitosis
Authors: K. M. Halprin
Journal: JAMA (1966)

In this form of self-induced lesions of the skin, patients have the unshakable conviction that they are infested with some insect of microscopic size. Excoriations and scars attest to the vigilance with which the pests have been searched for and destroyed with fingernails, knives, and caustics. A physician is consulted not to heal the wounds but to better identify and combat the invading parasites. Insignificant defects in normal skin are pointed out as harboring the parasite. Before the observing eye of the physician, the patient will demonstrate exactly how the search for and destruction of the parasite is accomplished. Fear of the parasite is surprisingly not part of the pattern, but rather it consists of an obsessional preoccupation accompanied by no little satisfaction when a likely bit of skin has been removed. As with "neurotic excoriations," lesions are predominantly in readily accessible areas such as the outer aspects of the
Aspirin Dose in Prevention of Myocardial Infarction
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolism of drugs.
Journal: BMJ (1970)

PointersDepressive Illness: A double-blind trial of imipramine in patients in general practice with sustained depressive illness showed it had no advantage over a placebo, a result which suggests that further evaluation is needed (p.773).Severely depressed patients whose corticosteroid levels were not suppressed by dexamethasone differed from those responding normally in showing greater agitation and less adverse childhood experience (p.789).Diabetic Women: Women with late-onset mild
COCAINIZATION OF THE SPINAL CORD.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An extracorporeal device to treat barbiturate poisoning. Use of anion-exchange resins in dogs
Authors: T. F. Nealon
Journal: JAMA (1966)

Each year in the United States there are more than 2,000 deaths due to barbiturates, accounting for more than 7% of all suicides.<sup>1</sup>Furthermore, in spite of all the new, potentially lethal pharmaceuticals introduced, barbiturates have been responsible for an increasing proportion of attempted suicides. This trend has been most marked in the last five years. When one considers that an estimated 7% of barbiturate suicide attempts are fatal<sup>2</sup>the incidence of barbiturate poisonings is apparently quite high. Several methods have been developed to treat the patient who is prostrated from an overdose of sleeping pills. These range from supportive therapy,<sup>3</sup>water diuresis,<sup>4</sup>alkaline diuresis,<sup>5-7</sup>alkaline or protein peritoneal dialysis,<sup>8</sup>to hemodialysis.<sup>9-11</sup>Although these methods are all applicable, a method of treatment more accessible, more rapid, and more economic would be desirable. In the past, most investigations with resins have been concerned with
Malignant Papulosis of Skin and Cerebrum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correlation between particle size, in vivo particle persistence, and lung injury
Authors: G Oberdörster, J Ferin, B E Lehnert
Journal: Environmental Health Perspectives (1994)

Dosimetry parameters such as deposition, clearance, retention, and translocation and dissolution of inhaled particles in and to different lung compartments may be important for the persistence of particles in the lung and may correlate with adverse pulmonary effects.We investigated such correlations using a model involving TiO2 particles of two particle sizes (20 nm diameter, ultrafine; 250 nm diameter, fine) of the same crystalline structure (anatase).A 12-week inhalation experiment in rats resulted in a similar mass deposition of the two particle types in the lower respiratory tract.The ultrafine particles elicited a persistently high inflammatory reaction in the lungs of the animals compared to the larger-sized particles.In the postexposure period (up to 1 year) retention in the alveolar space per se was not different between fine and ultrafine TiO2.However, the following differences between the particle types were noted: a significantly different total pulmonary retention, both quantitatively (significantly prolonged retention of the ultrafine TiO2) and qualitatively (increased translocation to the pulmonary interstitium and persistence there of the ultrafine TiO2); greater epithelial effects (Type II cell proliferation; occlusion of pores of Kohn) and the beginning of interstitial fibrotic foci with ultrafine TiO2; signifi- cant sustained impairment of alveolar macrophage function after ultrafine TiO2 exposure as measured by the clearance of test particles.A correla- tion between particle surface area and effects was observed.A comparison of the adverse reactions with dosimetric parameters of TiO2 in different lung compartments in the postexposure period showed a correlation of the persistence of effects in both the alveolar and interstitial space with the persistence of particles in the respective compartment.
Nuevas Orientaciones Sobre la Patogenia y Tratamiento de la Diabetes Insípida.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal