tbuckley/cabot-search huggingface dataset:
Delayed hemolytic transfusion reaction with acute renal failure
Authors: P. V. Holland
Journal: JAMA (1968)

Fever, hemoglobinemia, hemoglobinuria, oliguria, and a marked fall in hematocrit values developed in a patient with a bleeding peptic ulcer 13 days after he had received 4 units of apparently compatible blood. He went on to become frankly uremic and hyperkalemic, but eventually recovered. Results of routine serologic studies at the time of the transfusion reaction were normal, but an anti-Jk<sup>b</sup>antibody could be demonstrated when cells treated with trypsin were used in the indirect Coombs' test; the patient's blood type was found to be Jk (a +b-); the blood type of three of his four donors was Jk(b+).
Genesis of Gall-stones
Authors: J. A. Gardner, H. Gainsborough
Journal: BMJ (1933)

<b>397</b> <h3><b>Purpose:</b></h3> Static <sup>18</sup>F-FDopa PET images are currently used for identifying patients with glioma recurrence/progression after treatment, although the additional diagnostic value of dynamic parameters remains unknown in this setting. The aim of the present study was to evaluate the performances of static and dynamic <sup>18</sup>F-FDopa PET parameters for detecting patients with glioma recurrence/progression as well as to assess further relationships with patient outcome. <h3><b>Methods:</b></h3> Fifty-one consecutive patients who underwent an <sup>18</sup>F-FDopa PET for a suspected glioma recurrence/progression at post-resection MRI, were retrospectively included. Static parameters including tumor-to-normal-brain (TBR), tumor-to-striatum (TSR) SUV<sub>mean</sub> and SUV<sub>max</sub> ratios, and metabolic tumor volume (MTV), as well as dynamic parameters with time-to-peak (TTP) values and curve slope, were tested for predicting: 1) glioma recurrence/progression at 6-months after the PET exam and 2) survival on longer follow-up. <h3><b>Results:</b></h3> All static parameters were significant predictors of a glioma recurrence/progression (accuracy≥94%) with all parameters also associated with mean progression-free survival (PFS) in the overall population (all p&lt;0.001, 29.7 vs. 0.4 months for TBR<sub>max</sub>, TSR<sub>max</sub> and MTV). The curve slope was the sole dynamic PET predictor of glioma recurrence/progression (accuracy=76.5%) and was also associated with the mean PFS (p&lt;0.001, 18.0 vs. 0.4 months). However, no additional information was provided relative to static parameters in multivariate analysis. <h3><b>Conclusions:</b></h3> Although patients with glioma recurrence/progression can be detected by both static and dynamic <sup>18</sup>F-FDopa PET parameters, most of this diagnostic information can be achieved by conventional static parameters.
Comparing antibiotics: statistical rigor vs practicality
Authors: W. C. Blackwelder
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Lin et al<sup>1</sup>have concluded that seven days of ceftriaxone therapy is as effective as ten days of therapy in children with bacterial meningitis, based on the failure to find statistically significant differences in various measures of outcome between two randomized groups of 35 children each. While this conclusion may be correct, the evidence reported is not sufficient to support it. To illustrate, let us consider one of their findings: in each of the two treatment groups, four (11.4%) of 35 children had two or more neurological complications. This result suggests that the two treatments may have a similar effect. However, a 90% confidence interval for the difference between the true percentages is —12.5% to 12.5%; a statistical test at a two-sided 10% significance level would therefore not reject the hypothesis that the true percentages differ by as much as 12.5%. Thus, the study was too
GERMANY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome
Authors: Yuan Tian, Irina Voineagu, Sergiu P Pasca, Hyejung Won, Vijayendran Chandran, Steve Horvath, Ricardo E Dolmetsch, Daniel H Geschwind
Journal: Genome Medicine (2014)

Common genetic variation and rare mutations in genes encoding calcium channel subunits have pleiotropic effects on risk for multiple neuropsychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia. To gain further mechanistic insights by extending previous gene expression data, we constructed co-expression networks in Timothy syndrome (TS), a monogenic condition with high penetrance for ASD, caused by mutations in the L-type calcium channel, Cav1.2. To identify patient-specific alterations in transcriptome organization, we conducted a genome-wide weighted co-expression network analysis (WGCNA) on neural progenitors and neurons from multiple lines of induced pluripotent stem cells (iPSC) derived from normal and TS (G406R in CACNA1C) individuals. We employed transcription factor binding site enrichment analysis to assess whether TS associated co-expression changes reflect calcium-dependent co-regulation. We identified reproducible developmental and activity-dependent gene co-expression modules conserved in patient and control cell lines. By comparing cell lines from case and control subjects, we also identified co-expression modules reflecting distinct aspects of TS, including intellectual disability and ASD-related phenotypes. Moreover, by integrating co-expression with transcription factor binding analysis, we showed the TS-associated transcriptional changes were predicted to be co-regulated by calcium-dependent transcriptional regulators, including NFAT, MEF2, CREB, and FOXO, thus providing a mechanism by which altered Ca2+ signaling in TS patients leads to the observed molecular dysregulation. We applied WGCNA to construct co-expression networks related to neural development and depolarization in iPSC-derived neural cells from TS and control individuals for the first time. These analyses illustrate how a systems biology approach based on gene networks can yield insights into the molecular mechanisms of neural development and function, and provide clues as to the functional impact of the downstream effects of Ca2+ signaling dysregulation on transcription.
The United States needs a health system like other countries
Authors: W. A. Glaser
Journal: JAMA (1993)

Every developed country except the United States has a comprehensive health system for coverage, service provision, and finance. Social policy in the United States once was guided by thinkers who realized this, and the Social Security system—complete except for health insurance—resulted. The climate of thinking changed, and health policy for some time has been dominated by classical economists who argue that free competitive markets will solve all problems. They justify their arguments by claiming that the only alternative is full government takeovers of service and financing, as in Canada. While this debate has dragged along, problems in the United States have become grave. Instead of reviving the institutional economics and social policies that once served the United States well, the Clinton administration has turned policy over to devotees of managed competition. But the problem is how to organize the country, and national health insurance—easily observed in other countries—is superior to the current chaos and free-market utopias in the United States. Important aims would be achieved, such as expanding coverage, obtaining stable revenue, and containing costs. Important political barriers can be overcome, such as resistance by small business. Such a health system includes machinery for setting goals and implementing results, involving collaboration among providers, payers, and government. (<i>JAMA</i>. 1993;270:980-984)
A warning
Authors: F. Charatan
Journal: BMJ (2003)

18% (n = 23) in the relaxation training group, and 15% (n = 20) in the control group.At six months the proportion of participants who thought that their neck had fully or considerably recovered was 53% (n = 72) in the dynamic muscle training group, 23% (n = 30) in the relaxation group, and 17% (n = 22) in the control group compared with 26% (n = 35), 23% (n = 30), and 12% (n = 16), respectively, at 12 months.
Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2
Authors: Susan E. Hiby, Richard Apps, Andrew M. Sharkey, Lydia E. Farrell, Lucy Gardner, Arend Mulder, Frans H. Claas, James J. Walker, Christopher W. Redman, Linda Morgan, Clare Tower, Lesley Regan, Gudrun E. Moore, Mary Carrington, Ashley Moffett
Journal: Journal of Clinical Investigation (2010)
DISEASE TRANSMISSION AND THE SCHOOL
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nervous system toxic effects of cancer therapy
Authors: I. D. Goldberg
Journal: JAMA (1982)

SERIOUS damage to the nervous system from radiation therapy or chemotherapy is uncommon, and its pathogenesis is poorly understood. Although there are numerous elaborate descriptions of neuropathological changes, the relevant definition of tolerance to these modes of therapy is based on function. Recently, thresholds for serious neurological damage have begun to be established through clinical observations and experiments with animal models. <h3>RADIATION TOXICITY</h3> The precise targets and mechanisms involved in neurological injury from ionizing radiation are complex. Intrinsic neural tissue seems to be more resistant to radiation injury than the supporting glial tissue and capillary endothelium; in late radiation injury in particular, damage to small and medium vascular arterioles is considered to be the etiology.<sup>1-4</sup>When neurological damage occurs, blood vessel abnormalities—including hyalinization, fibrinoid necrosis of the vessel walls, luminal obliteration, and thrombosis—are prominent in both the damaged area of the brain and the surrounding normal tissue. Demyelination is
Familial Bilateral Carotid Body Tumors
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of the dean and faculty in governance of the medical school
Authors: J. R. Hogness
Journal: JAMA (1968)

We need only look at the turnover rate of deans of medical schools to realize that something is amiss. The average dean is not totally happy in his job. This is in part because of the pressures put on him from many sources, but it is also because he is usually untrained for the role he must play. Further, as soon as he leaves the fold of the faculty and assumes the mantle of dean, he is invested in the eyes of the faculty with a strange and wonderful aura. Edward Rosenheim, Jr., professor of English at the University of Chicago, has written a classic "Letter to a New Dean."1 Addressing his friend Fats, the new Dean of Floodwater State University, Rosenheim comments, You are, of course, an amiable and humble man; beware, however, the illusion that the deanship involves a subtle, special expertise, the mastery of a craft whose
A prospective study of injuries in ncaa intercollegiate ice-hockey goaltenders
Authors: C Wijdicks, S Spiridonov, R LaPrade
Journal: British Journal of Sports Medicine (2011)

Background While relatively well protected and padded, ice-hockey goaltenders are at risk for impact injuries. Objective To study incidence and mechanism of intercollegiate ice-hockey goaltender injuries. Design Analyzed seasons prospectively starting in 2000–01 through 2006–07. Setting All National Collegiate Athletic Association (NCAA) ice-hockey goaltender injuries through the Injury Surveillance System. Participants NCAA ice-hockey goaltenders. Assessment of risk factors Injury rates were calculated per 1000 player games. Main outcome measurements Injury rates. Results The overall rate of NCAA men's ice-hockey goaltender injuries was 0.5/1000 player games. 56 men's ice-hockey goaltender injuries resulted in further time loss from practices or games. 13 injuries resulted in time loss of 1–2 days, 18 resulted in time loss of 3–5 days, 10 injuries resulted in time loss of 6–9 days, and 10 injuries resulted in 10 or more days of time loss from competition. The overall rate of NCAA women's ice-hockey goaltender injuries was 0.72/1000 player games. Overall, women sustained 23 time-loss game injuries. Five of these resulted in further loss of on-ice practice/game times of 1 day, eight resulted in 3–5 days of time loss, two resulted in 6–9 days of time loss, and seven injuries resulted in 10 or more days of time loss. Conclusions Further understanding of the aetiology of these on-ice goaltender-player contact injuries could assist in the development of possible interventions to reduce the incidence of NCAA ice-hockey goaltender injuries. The current Injury Surveillance System has shortcomings and does not provide us with enough information to evaluate the effectiveness of goalie equipment and the impact that possible rule changes would have on the game. This study is the first step in analyzing all participants in hockey with anticipation for future rule and equipment optimisation and subsequent injury reduction.
Update: Rashes Among Schoolchildren—27 States, October 4, 2001–June 3, 2002
Journal: JAMA (2002)

Since October 2001, a total of 27 states has reported investigations of multiple groups of schoolchildren who have developed rashes. Rash illnesses among schoolchildren in 14 states were reported in March; since the initial report, rashes have been reported in 13 additional states (Alabama, Alaska, Illinois, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Minnesota, Missouri, New Hampshire, and New Jersey). Rashes also have been reported among schoolchildren in Canada. The investigations have not identified a common source for the reported cases of rashes among U.S. schoolchildren. This report summarizes available data on these rashes and provides examples for three states. CDC is continuing to monitor reports of rashes and is providing technical assistance to state and local health departments investigating these reports.
Is Monkeypox a Reservoir of Smallpox?
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What's new in the other general journals
Authors: Alison Tonks
Journal: BMJ (2006)

Americans with painful osteoarthritis spend an estimated $700 million a year on glucosamine and chondroitin sulfate, hoping these dietary supplements will help their pain. The latest attempt at rigorous evaluation suggests they don't. In a large randomised trial (n = 1583), patients taking the supplements alone or in combination were no better after 24 weeks than patients taking placebo. Credit: N ENGL J MED To measure response, researchers looked for a 20% improvement in pain as measured by the WOMAC (Western Ontario and McMaster Universities osteoarthritis) index. Response rates were 64% (203/317), 65% (208/318), 67% (211/317), and 60% (188/313) among patients taking glucosamine hydrochloride, chondroitin sulfate, both, or placebo, respectively. A fifth group of patients who took celecoxib did significantly better than the placebo group, but only by a disappointing 10% (response rate 70% (223/318); P = 0.008). There were hints that the combined supplements might work for people with more severe pain (response rate 79% (57/72); P = 0.002). But this finding is not secure, according to a linked editorial (pp 858-60). Many research dollars have already been spent evaluating these supplements, and the balance of evidence is now against them, at least for the treatment of pain. It's still possible that they modify the underlying disease, however. These authors are due to report on this aspect of treatment later this year. N Engl J Med 2006;354: 795–808 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] More than 90% of influenza A viruses circulating in the US are now resistant to amantadine and rimandatine, according to the latest surveillance figures. The prevalence of resistance among these viruses has jumped from 11% during the 2004-5 influenza season (October to 3) to 92% during the first half of the current influenza season (October to December 2005), prompting the US Centers for Disease Control and Prevention to urge doctors not to prescribe adamantanes for the rest … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DClegg%26rft.auinit1%253DD.%2BO.%26rft.volume%253D354%26rft.issue%253D8%26rft.spage%253D795%26rft.epage%253D808%26rft.atitle%253DGlucosamine%252C%2Bchondroitin%2Bsulfate%252C%2Band%2Bthe%2Btwo%2Bin%2Bcombination%2Bfor%2Bpainful%2Bknee%2Bosteoarthritis.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa052771%26rft_id%253Dinfo%253Apmid%252F16495392%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa052771&link_type=DOI [3]: /lookup/external-ref?access_num=16495392&link_type=MED&atom=%2Fbmj%2F332%2F7540%2F536.atom [4]: /lookup/external-ref?access_num=000235456200004&link_type=ISI
DISEMBODIED PRACTITIONERS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal