tbuckley/cabot-search huggingface dataset:
Prospective study of wide local excision and endocrine therapy without radiotherapy (WORTH) for node-negative, estrogen receptor-positive early breast cancer with negative histologic margins (WORTH trial, Protocol 1): Five-year interim results.
Authors: R. Nishimura, S. Ohsumi, H. Inaji, Y. Ohashi, K. Suemasu, N. Masuda, S. Akashi-Tanaka, S. Murakami, T. Ikeda, T. Nishi
Journal: Journal of Clinical Oncology (2010)

568 Background: Breast-conserving surgery (BCS) followed by radiotherapy (RT) is considered standard for early breast cancer. However, there is some controversy for the use of RT after BCS in breast cancer (BC) with favorable features, where endocrine treatment contributes to a reduction in local recurrence (LR). Moreover, surgical margin status correlates with LR. We conducted a trial to confirm the validity of 5-mm negative margin policy in BCS without RT using the stringent entry criteria. Methods: We started a prospective trial in Oct. 2002, in which we enrolled the BC patients (pts) who fulfilled all the following 7 criteria from 13 hospitals after BCS, and treated them with tamoxifen or anastrozole for 5 years. The criteria are: 1) tumor size of 3 cm or less by palpation; 2) node negative; 3) no preoperative treatment; 4) 50 years or older at operation and postmenopausal; 5) excised materials were sliced at 5 mm intervals with all slices showing 5 mm tumor free from the margins; 6) no lymphovascular involvement (LI); and 7) ER positive. The sequential probability ratio test (null hypothesis: annual LR rate < 0.01) was applied to monitor the trial. Results: A total of 123 pts were enrolled, and entry was closed in Mar. 2005. The median age, tumor size and follow-up period were 64 (range: 51-84) years, 1.5 (range: 0-30) cm and 60 (range: 21-83) months, respectively. Seventy percent of pts had PgR positive tumors and 6.3% had tumors with HER2:2+/3+, and 12.2% received re-excision. Six pts (0.98 events/100 person-years) had LR. Regarding predictive factors for LR, age, tumor size, PgR, HER2 and re-excision did not correlate with LR; however, the histological type (mucinous or others) was a significant factor. Mucinous carcinoma had a higher LR rate in cases without RT, but the pts did not experience distant metastasis. Conclusions: Postoperative RT to the breast could be abbreviated in postmenopausal women with node-negative and small-size BC that have favorable features and negative margins. The above mentioned criteria including the 5-mm policy might secure the safety of BCS without RT. No significant financial relationships to disclose.
Research on teaching and learning medicine
Authors: S. E. Ross
Journal: JAMA (1965)

Teaching medicine is a profession and a pleasure, a vocation and an avocation. It is also, as current research convincingly shows, a form of behavior that can be studied, measured, and modified under controlled conditions.<sup>1-3</sup> General educational research has an active and growing national organization, the American Educational Research Association (AERA), which produces informative reviews of current work through the<i>Review of Educational Research</i>, has developed an<i>Encyclopedia of Educational Research</i>, and, in the<i>Handbook of Research on Teaching</i>, has created what is "likely to be voted the most influential educational book of the half century."<sup>4</sup> Research in medical education is a relatively new field of endeavor. Although the Association of American Medical Colleges has supported such systematic study for more than a decade, educational research is formally represented in the organizational pattern of only seven medical schools; the oldest of these programs was established in 1959. Other
Highlights
Journal: JAMA Psychiatry (2017)

Suicides have increased in the United States, but trends among sociodemographic and clinical groups have not been characterized.Using nationally representative survey data, Olfson and colleagues found that the percentage of adults making a recent suicide attempt increased from 0.62% in 2004/2005 to 0.79% in 2012/2013.The increase in risk was significantly larger among younger adults and among adults with no more than a high school education.In an Editorial, Caine discusses implications for suicide research.
Leukokinetic Studies
Authors: C. R. Bishop, G. Rothstein, H. E. Ashenbrucker, J. W. Athens
Journal: Journal of Clinical Investigation (1971)

The kinetics of blood neutrophils was investigated by means of the in vitro radioactive diisopropyl fluorophosphate method in 35 patients with a chronic, steady-state neutropenia. There were 17 patients in whom the half disappearance time of neutrophils was normal. In 10 of these patients, the production of neutrophils was low and in 7, production was normal. In 18 patients the half disappearance time of neutrophilic granulocytes was shorter than normal. The production of neutrophilic granulocytes was low in five of these patients, normal in eight patients, and increased in five. An attempt was made to correlate other laboratory measurements with the kinetic picture, but no relationship was found; the marrow neutrophil reserve as measured by endotoxin or cortisol injection; marrow cellularity on aspiration or biopsy; in vitro-labeling index with (3)HTdR; or serum lysozyme concentration proved of no value in identifying the various kinetic groups. The only finding that seemed to correlate with the kinetic picture was the presence or absence of splenomegaly. In 12 of the 18 patients with a short half disappearance time, splenomegaly was present whereas in 15 of 17 patients with a normal half disappearance time, there was no splenomegaly. Of 20 patients with greater than 1000 neutrophils per mm(3), 17 were found to have a normal total-blood neutrophil pool. Thus these patients, with many of their cells marginated, agree to have a "shift neutropenia."Myelocyte to blood transit time and myelocyte generation time, as measured in seven patients by in vivo labeling with diisopropy fluorophosphate, proved to be essentially normal. Thus, it appears that in chronic neutropenia, increased or decreased production of neutrophils is accomplished by increasing or decreasing early precursor input into the system.
Perinatal Group B Streptococcal Disease After Universal Screening Recommendations—United States, 2003-2005
Journal: JAMA (2007)

Group B streptococcus (GBS) is a leading cause of neonatal morbidity and mortality in the United States. In 2002, CDC, the American College of Obstetricians and Gynecologists (ACOG), and the American Academy of Pediatrics (AAP) issued revised guidelines for the prevention of perinatal GBS disease. These guidelines recommend universal screening of pregnant women by culture for rectovaginal GBS colonization at 35-37 weeks' gestation and the use of intrapartum antibiotic prophylaxis for GBS carriers. To examine rates of neonatal and pregnancy-associated GBS disease after the revised guidelines were issued, CDC analyzed surveillance data from the Active Bacterial Core surveillance (ABCs) system from the period 2003-2005 and compared them with data from 2000-2001, the period immediately preceding the universal screening recommendations. This report describes the results of that analysis, which indicated that annual incidence of early onset GBS disease (i.e., in infants aged 0-6 days) was 33% lower during 2003-2005 than during 2000-2001. However, although incidence among white infants decreased steadily during 2003-2005, incidence increased 70% among black infants. Incidence of GBS disease among infants aged 7-89 days (i.e., late-onset disease) and pregnant women remained stable after revised universal screening guidelines were issued. Continued surveillance is needed to monitor the impact of the guidelines on perinatal GBS disease and trends in racial disparities and to guide interventions to reduce disparities.
Medical education in the United States. IV. AMA Vietnam medical school project
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts of the 26th Annual Conference of the International Society for Environmental Epidemiology (ISEE), 24–28 August 2014, Seattle, Washington
Journal: Environmental Health Perspectives (2014)

The 26th annual conference of the International Society for Environmental Epidemiology was held 24-28 August 2014 in Seattle, Washington. The conference theme was "From Local to Global: Advancing Science for Policy in Environmental Health." Sessions highlighted results assessing the burden of diseases from environmental exposures and key areas related to topics of uncertainty for policy makers.
Autoimmune Panleukopenia
Authors: Martin J. Cline, Gerhard Opelz, Andrew Saxon, John L. Fahey, David W. Golde
Journal: New England Journal of Medicine (1976)

A patient with episodic panleukopenia involving neutrophilic granulocytes, monocytes and lymphocytes had recurrent bacterial infections and a circulating cytotoxin that injured primitive myeloid cells as well as differentiated granulocytes and mononuclear cells. The cytotoxin was an immunoglobulin with activity against mouse, as well as human, myeloid stem cells. Clinical remission during cyclophosphamide therapy was associated with disappearance of the circulating leukocytotoxin. Serum from a period of active disease was cytotoxic for the patient's own lymphocytes obtained during clinical remission. Absorption of cytotoxic serum with granulocytes removed activity against both granulocytes and lymphocytes. These studies suggest an autoimmune disease in man characterized by episodic granulocytopenia, monocytopenia and lymphocytopenia due to humoral antibody against non-HLA antigens shared by several hematopoietic cell lines.
TRAIL Gene Therapy for Lung Cancer
Authors: Dexian Zheng
Journal: Cancer Research (2005)

In the article on TRAIL gene therapy for lung cancer in the March 1, 2005, issue of Cancer Research (1), Dr. Dexian Zheng should have been listed as a co-corresponding author: Dexian Zheng, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China. Phone: 8610-6529-6409; Fax: 8610-6510-5102; E-mail: zhengdx@pumc.edu.cn.
Herrick's Diagnosis. A Handbook of Medical Diagnosis.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Billy O
Authors: Patrick Mallam
Journal: JAMA (1969)

A child is readily perceptive of the outward traits and mannerisms of those around him. The cast is, as it were, still small and the stage brightly lit; and the actors produce an etched impress never quite obliterated. Only later in life does the clarity of individuals become gradually dulled as the long pageant of the passing show grows increasingly crowded by a mass of ill-defined and mingled figures. Just as the central characters, fairy, human, or animal, of a childhood's story book are more real and vivid than those of later reading, so are the people of his acquaintance. Unfortunately, in this context at least, we none of us have prevision, and, in early years particularly, content ourselves with superficial impressions only. The deeper observations of character and behaviour which would have given so much personal felicity in mature age, and even had historical value some decades later, remain
Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: A placebo-controlled trial
Authors: C Lai
Journal: Hepatology (1997)

Lamivudine is a novel 2′,3′-dideoxy cytosine analogue that has potent inhibitory effects on hepatitis B virus replication in vitro and in vivo. We performed a single-blind, placebo-controlled study to assess its effectiveness and safety in Chinese hepatitis B surface antigen (HBsAg) carriers. Forty-two Chinese HBsAg carriers were randomized to receive placebo (6 patients) or lamivudine orally in dosages of 25 mg, 100 mg, or 300 mg daily (12 patients for each dosage). The drug was given for 4 weeks. The patients were closely monitored clinically, biochemically, and serologically up to 4 weeks after drug treatment. All 36 patients receiving lamivudine had a decrease in hepatitis B virus (HBV) DNA values of >90% (P < .001 compared with placebo). Although 25 mg of lamivudine was slightly less effective than 100 mg (P = .011) and 300 mg (P = .005), it still induced 94% suppression of HBV DNA after the fourth week of therapy. HBV DNA values returned to pretreatment levels within 4 weeks of cessation of therapy. There was no change in the hepatitis B e antigen status or in aminotransferase levels. No serious adverse events were observed. In conclusion, a 4-week course of lamivudine was safe and effective in suppression of HBV DNA in Chinese HBsAg carriers. The suppression was >90% but reversible. Studies with long-term lamivudine administration should be performed to determine if prolonged suppression of HBV DNA can be achieved.
Cardiovascular Risk Factors in Hematopoietic Cell Transplantation (HCT) Survivors: Role in Development of Subsequent Cardiovascular Disease
Authors: Saro H. Armenian, Can-Lan Sun, Tabitha Shannon, Emily Blum, Liton Francisco, K Venkatraman, Raynald Samoa, F. Lennie Wong, Stephen J. Forman, Smita Bhatia
Journal: Blood (2011)
Genetic Cocktails
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Manual and Atlas of Medical Ophthalmology.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, November–December 1971.
Journal: JNCI Journal of the National Cancer Institute (1972)

Manuscripts Approved for JNCI, November–December 1971. Get access JNCI: Journal of the National Cancer Institute, Volume 48, Issue 1, January 1972, Pages 281–282, https://doi.org/10.1093/jnci/48.1.281-a Published: 01 January 1972
Corneal Disease Due to Smallpox.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 608: HOXB7 as a key regulator in the development of tamoxifen resistance
Authors: Kideok Jin, Tao Zhu, Tariq Shah, Zaver M. Bhujwalla, Saraswati Sukumar
Journal: Cancer Research (2010)

Abstract Multiple factors including long term treatment with tamoxifen are involved in the development of selective estrogen receptor modulator resistance of ERα positive breast cancer. It is well known in the endocrinology field that increased levels of ErbB/HER family members can also directly alter the cellular response to tamoxifen, but the mechanisms underlying increased expression of ErbB/HERs are not clear. In this report we show that HOXB7 is an ERα responsive gene and the downregulation of HOXB7 expression by estradiol is abrogated by tamoxifen in MCF7 cells. HOXB7 overexpression renders MCF-7 cells resistant to tamoxifen via cross-talk between receptor tyrosine kinases and ERα signaling. EGFR and HER2 expression is upregulated by overexpression of HOXB7, while knockdown of HOXB7 with siRNA in tamoxifen-resistant cell lines causes decrease of EGFR and HER2 expression and loss of tamoxifen resistance. In addition, our work demonstrates that to mediate upregulation of EGFR and HER2, HOXB7 binds to ER-alpha and promotes HER2 transcription activity through direct binding to the HER2 enhancer region by competing with other cofactors. Also, HOXB7 enhances EGFR transcription activity via binding to EGFR promoter region. However, depletion of HOXB7 affects the binding affinity of HOXB7 and the cofactors to the HER2 enhancer element. Higher expression levels of HOXB7 significantly correlated with poorer disease free survival in ERα positive breast cancer patients on adjuvant tamoxifen monotherapy. These findings implicate overexpression of HOXB7 as a key event in the initiation and maintenance of tamoxifen resistance. These studies suggest that HOXB7 acts as a key regulator orchestrating two major groups of target molecules in the oncogene heirarchy. Functional antagonism of HOXB7 could circumvent tamoxifen resistance. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 608.
Editorial
Authors: S.G.O. Johansson
Journal: Allergy (2002)

The Junior Members and Junior Affiliate Members of EAACI represent a group of more than 750 clinicians and scientists under the age of 35 years. During previous years, EAACI has developed specific activities and promotions to support and to increase the influence of the younger members. It is thus most appropriate to also give EAACI Junior Members a chance to become involved in Allergy. Over the 10 years that Allergy has been the official journal of EAACI it has developed into the allergy journal with the largest circulation in Europe. The EAACI Junior Member group was some time ago invited to take responsibility for an Allergy Review Series covering areas of special interest to them. I am pleased to introduce Ass. Prof. Ioana Agache, on behalf of the EAACI Junior Member group, to start the Review Series “Junior Review Selection” in this issue of Allergy. It is my hope that this new Series will be of interest to all EAACI Members and thus both promote knowledge and interest in allergy in Europe and also the quality of our journal Allergy. S.G.O. Johansson Editor-in-Chief
Consent for autopsies
Authors: S. Schmidt
Journal: JAMA (1983)

DIFFERENT laws apply to the granting of permission to perform an autopsy, depending on whether authorization is ordered primarily for legal purposes or requested for medical purposes. Generally, the surviving spouse or next of kin of the deceased can authorize or prohibit an autopsy. This article explores the consent issues, emphasizing the variations among the applicable state laws. The various autopsy laws are analyzed and compared. <h3>MEDICAL AUTOPSIES BY CONSENT</h3> Proper authorization for a nonofficial autopsy must be obtained to avoid possible civil or criminal liability of the physician performing the autopsy. A legal action for damages against a physician, coroner, or medical examiner can arise when the autopsy has not been consented to by the proper party, unless otherwise provided by law. In general, the person with the right or duty to dispose of the body is entitled to possession and receipt of the body without delay, in the