tbuckley/cabot-search huggingface dataset:
Stab wounds of the abdomen. Observe or explore?
Authors: J. R. Wilder
Journal: JAMA (1980)

This article reviews our experience with 403 cases of stab wounds of the abdomen, with emphasis on our policy of selective management. Forty-six percent (187) of the patients were operated on immediately because of clinical findings. Fifty-four percent (216 patients) were treated conservatively after initial evaluation, and only 4% (16 patients) required subsequent surgical intervention, with no mortalities. The overall morbidity was 9.2%, with a 1.6% mortality in the operative group. With more than 20 years of experience in the management of stab wounds, we found the selective approach to be safe and reliable. (<i>JAMA</i>243:2503-2505, 1980)
Abstract 1333: Modulation Of Cardiac Beta-adrenergic Responsiveness By The Neuronal Nitric Oxide Synthase/Sarcolemmal Calcium Pump Complex
Authors: Tamer M Mohamed, Delvac Oceandy, Nasser Alatwi, Florence Baudoin, Elizabeth J Cartwright, Ludwig Neyses
Journal: Circulation (2007)

The pivotal role of neuronal nitric oxide synthase (nNOS) in regulating cardiac function has only recently been unveiled. Notably, others have shown that responsiveness to β-adrenergic stimulation is dependent on nNOS activity. In a cellular model, we showed that the Ca 2+ /calmodulin-dependent nNOS activity is reduced by overexpression of isoform 4b of the plasma membrane Ca 2+ /Calmodulin-dependent Ca 2+ -pump (PMCA4b), which binds to nNOS. We demonstrated that PMCA4b overexpression in the heart reduced β-adrenergic responsiveness in vivo via an nNOS dependent mechanism (Oceandy et al, Circulation 2007). Here we investigated the cellular mechanisms of the regulation of the β-adrenergic response by PMCA4b. We used an adenoviral system to overexpress PMCA4b (PMCA4b cells) or LacZ (control, C) in neonatal rat cardiomyocytes. PMCA4b cells showed an 18±5% and 24±5% reduction in nitric oxide (DAF-FM fluorescence) and cGMP levels, respectively (n=6, p&lt;0.05 each) compared to C demonstrating the regulation of NO production by the PMCA4b in this system. Since nNOS has been shown to regulate phospholamban (PLB) phosphorylation, we examined phosphorylation of PLB at Ser16. PMCA4b cells showed a significant increase in Ser16-PLB at baseline (66±17%, p&lt;0.05) compared to C. As a result of increased baseline Ser16-PLB in PMCA4b cells, β-adrenergic stimulation of PMCA4b cells using 2μM isoproter-enol (IP) showed reduced relative induction in Ser16-PLB (23±10% vs. 78±19% in C; n=5, p&lt;0.05). Further analysis in adult cardiomyocytes isolated from our PMCA4b transgenic mice (PMCA4b TG) demonstrated that PMCA4b TG showed 3-fold higher Ser16-PLB phosphorylation at baseline compared to wild type (WT) myocytes and the relative response following β-adrenergic stimulation was significantly reduced (1.2±0.2 fold induction after IP treatment in PMCA4b TG, vs. 3.1±0.7 in WT, n=5, p&lt;0.05). Thus, PMCA4b regulates NO production from nNOS, which in turn modulates cGMP levels and PLB phosphorylation. These findings provide mechanistic insight into the regulation of the β-adrenergic response in the heart by PMCA4b and place this Ca 2+ -pump upstream of the recently described pathway linking nNOS and Ser16-PLB phosphorylation and downstream of the β-adrenergic receptor(s).
Notice to Readers: New Web Location for Weekly and Annual NNDSS Data
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

To improve the usability, availability, quality, and timeliness of surveillance data as part of the CDC Surveillance Strategy (1), CDC will provide users a convenient way to access notifiable infectious and noninfectious disease data through the National Notifiable Diseases Surveillance System (NNDSS) website.CDC has redesigned the data and statistics section of the NNDSS website to be a one-stop shop for users to find both detailed information about the notifiable disease data and links to the weekly and annual data.Although these data will no longer be published in their current format in MMWR, users can easily access the information on the NNDSS website.To ease the transition, MMWR also will link users from its website to the new location on the NNDSS website.
502O_PR Optimal first line systemic therapy in patients (pts) with metastatic angiosarcoma: A report from the Asian Sarcoma Consortium
Authors: T.W.-W. Chen, A. Pang, M.E. Puhaindran, M.M. Maw, H.H. Loong, V. Sriuranpong, C.-C. Chang, S. Teo, S. Mingmalairak, T. Hirose, M. Endo, A. Kawai, M. Farid, S.H. Tan, W.L. Goh, R. Quek, J.C. Chan, A.K.C. Leung, R. Ngan
Journal: Annals of Oncology (2016)
High somatic mutation and neoantigen burden do not correlate with decreased progression-free survival in HCC patients
Authors: Maria Tagliamonte, Angela Mauriello, Roberta Zeuli, Beatrice Cavalluzzo, Annacarmen Petrizzo, Maria Lina Tornesello, Franco M. Buonaguro, Michele Ceccarelli, Luigi Buonaguro
Journal: Journal of Hepatology (2020)
Characterization of Stroke Signs and Symptoms: Findings from the Atherosclerosis Risk in Communities Study
Authors: Saif S Rathore, Wayne D Rosamond, Lawton S Cooper, Lloyd E Chambless, Herman A Tyroler, Albert R Hinn
Journal: Circulation (2001)

P59 Background: Although patterns of stroke occurrence and mortality have been well studied, little epidemiologic data are available regarding the clinical characteristics of stroke events. Methods: We evaluated hospitalized stroke events reported in the Atherosclerosis Risk in Communities Study to describe the clinical characteristics of incident stroke. Incident confirmed stroke cases (n=474) were evaluated for stroke symptoms including headache, vertigo, gait disturbance, and convulsions. Cases were also evaluated for stroke signs including hemianopia, diplopia, speech deficits, paresis, and parasthesia/sensory deficits. Stroke characteristics were also evaluated for univariate associations with race, gender, and stroke subtype. Results: Over an average follow-up of 9.2 years, 407 (86%) ischemic and 67 (14%) hemorrhagic strokes occurred. Stroke symptoms in order of decreasing frequency (95% confidence intervals) were headache (27.4%, 23.4%-31.4%), gait disturbance (10.8%, 7.9%-13.6%), convulsions (4.4%, 2.6%-6.3%), and vertigo (2.1%, 0.8%-3.4%). Speech deficits occurred in 64.1% (59.8%-68.5%), hemianopia in 14.6% (11.4%-17.7%), and diplopia in 5.5% (3.4%-7.5%) of cases. Most cases involved paresis (81.6%, 78.1%-85.1%), predominantly of the arms (75.5%, 71.6%-79.4%). Fewer subjects experienced sensory deficits (44.5%, 40.0%-49.6%), predominantly in the arms (38.6%, 34.2%-43.0%). Blacks were more likely than whites to experience paresis (85.8% vs 77.9%, p=0.03). Men were more likely than women to experience a gait disturbance (14.3% vs 6.7%, p=0.001). As expected, persons with hemorrhagic strokes had a higher proportion of headaches (59.7% vs 22.1%, p=0.001) and convulsions (11.9% vs 3.2%, p=0.001) than those with ischemic events, while speech deficits were more common in ischemic strokes (68.1% vs 40.3%, p=0.001). Conclusions: We present epidemiologic data concerning the clinical characteristics of incident stroke in a population-based cohort. While minor differences by race, gender, and stroke subtype were observed, data from additional follow-up is required to confirm observed variation.
Report on M, Pasteur's Researches on Rabies and the Treatment of Hydrophobia by Preventive Inoculation
Authors: M. W. Vignal
Journal: BMJ (1886)

HUMAN RACE.-14ocufation with Rabid Viruts cspecially prepared as a Prophylactic Mef re for the Humnan R=ace.-I1cubation-Period shortened by Successive Inoc&lation in thie same Specics.-ExperiMntCs With the same Virus carried on during Thrcc YIears.-tetiod of atenuating the Vinus in Dry Air.-How to soon Xender a Dog Refractory to Hydrophobia.-FirstInoculation of a Human Subjeet for Hydropwobia.-Order of Inoculations.-Virtsiin azbid Spinal Cords prepared in Dry Air.-Micro-OrganismnsSccrete a Substanec Hostile to their Developmwnt.-Interpretation of P1vhnwmcna Observed.-Detailsconcrning Inoculation.Inoculation with Rabid Vsrus specially preparecd as a Prophylactic casutre for the human PPace.-M.Pasteur continued to carry on his researches, when, as he said in a subsequent note (October 26th, 1885 to the Academy of Sciences, there arrived a moment when he was almost forced to apply his method to the human subject (July 4th, 1885).Before taking this momentous step, be perfected the method he had experimentally demonstrated before the Hydrophobia Com- mission already mentioned.As he admits himself; his method was nlore scientific than practical." Its application to twenty dogs might
Disseminated Cysticercosis
Authors: Qiang Meng, Lingchun Liu
Journal: New England Journal of Medicine (2016)

A 23-year-old woman presented with headache, vomiting, syncope, weight gain, and leg pain. MRI of the head and thighs revealed diffuse hyperintense cystic lesions, and antibodies to cysticerci were detected in the serum and CSF.
Be Careful What You Wish For
Authors: Barbara S. Ducatman
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Texas State Medical Association. Sixteenth Annual Session.
Authors: None C. E. W.
Journal: JAMA (1884)

The majority of the papers contributed to this publication are short and practical. Dr. R. P. Talley has found the hypodermic use of bimunate of quinine and urea very beneficial, particularly in pernicious malarial fever. To avoid abscess he injects deeply, slowly emptying the syringe as the needle is withdrawn. Dr. C. W. Trueheart reports an interesting case of the "reproduction of two and three-quarter inches of the clavicle in the human subject by grafting with periosteum and with thin laminæ of bone covered by its periosteum, taken from the dog." One gentleman is considerably astonished at finding pediculi on the eyelids. This is a frequent source of wonder to careless students, and they are generally considerably disgusted when they find that this species is their old acquaintance Pediculus pubis.
Colon Polyps and Cancer
Authors: J. Bond
Journal: Endoscopy (2005)

The role of endoscopy, in particular colonoscopy, clearly is paramount in the screening, diagnosis, and prevention of colorectal cancer. In preparation for writing this "state-of-the-art" review on colon polyps and cancer, a PubMed literature search linking the topic with endoscopy yielded an enormous number of papers published in peer-reviewed journals just in the past 12 months. I have selected a few of these to highlight that I believe are most germane to current issues of risk stratification, screening and surveillance, prevention, and the premalignant potential of different types of adenomas detected by endoscopy. Several of these papers address the advantages and limitations of direct colonoscopy screening for colorectal neoplasia, and discuss the emerging role of virtual colonoscopy screening.
Vera Drake
Authors: Khalid Ali
Journal: BMJ (2004)

Directed by Mike Leigh US release date: 22 October 2004 Expected UK release date: 7 January 2005 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> I n Vera Drake , which won the prestigious Golden Lion award at September's Venice Film Festival and opened the Times /British Film Institute London Film Festival last month, the veteran English director Mike Leigh continues his dissection of the trials and tribulations of English family life that he began in his first film, Bleak Moments (1971). Set in 1950's London, the film follows the perfect family life that Vera (Imelda Staunton) and her husband, Stan (Phil Davis), enjoy with their son and daughter. Vera also cares for her elderly mother, and supports her … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Infant Mortality—United States, 1993
Journal: JAMA (1996)

The final infant mortality (death before age 1 year) rate for the United States for 1992-8.5 infant deaths per 1000 live-born infants--was the lowest rate ever recorded and represented a decrease of 4.5% from the rate of 8.9 for 1991 (Figure 1). Based on provisional data, the trend in declining infant mortality continued through 1993 (rate: 8.3). This report characterizes infant mortality in 1992 using information from birth and death certificates compiled by CDC's National Center for Health Statistics and compares findings with those for 1991.
6. Glycemic Targets: <i>Standards of Medical Care in Diabetes—2019</i>
Journal: Diabetes Care (2018)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
National surveillance of AIDS in health care workers
Authors: A. R. Lifson
Journal: JAMA (1986)

Information obtained for all persons with the acquired immunodeficiency syndrome (AIDS) reported to the Centers for Disease Control, Atlanta, includes a question about employment in a health care or clinical laboratory setting. As of May 1, 1986, a total of 922 (5.5%) of 16 748 adults with AIDS reported employment in such settings. Ninety-five percent of these health care workers belonged to recognized high-risk groups for AIDS; the proportion with "no identified risk" has not increased with time. All AIDS patients (including health care workers) who do not belong to high-risk groups are referred for further investigation. Of 88 health care workers initially reported with no identified risk, ten were from countries where heterosexual transmission is believed to play a major role; additional information was unobtainable or incomplete for 17 individuals. Of 61 persons on whom interviews or other follow-up information was obtained, 44 (73%) were reclassified. Specific occupational exposures that could be implicated as the source of human immunodeficiency virus infection were not identified for any health care workers with AIDS. A review of surveillance data supports other studies indicating that the risk of human immunodeficiency virus transmission in the occupational setting is low. (<i>JAMA</i>1986;256:3231-3234)
Autopsy Studies in Atherosclerosis
Authors: JAMES C. ROBERTS, CAMPBELL MOSES, ROBERT H. WILKINS
Journal: Circulation (1959)

Gross lesions of atheroselerosis in many arterial sites were graded in 500 consecutive autopsies in a general hospital. The grading system used took into account both the total area of intimal involvement and the severity of individual lesions. The first report analyzes the distribution and severity of atherosclerosis in the 347 men and women of the study group who died without morphologic evidence of atherosclerotic catastrophe in the heart, aorta, or brain. The second report describes the atherosclerotic lesions in patients who died with evidence of atherosclerotic catastrophe. The third report carries out a similar investigation in those subjects who presented evidence of obesity, hypertension, nephrosclerosis, and rheumatic heart disease.
Routine Bilateral Exploration for Inguinal Hernia in Children
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DOMESTIC ABSTRACTS
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leo Lamphere
Authors: William A. Hoffman
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Leo Lamphere is still making the rounds, apparently now in the northeast. He was seen for a few hours at Park City Hospital, Bridgeport, on Nov 5, 1964, and left quickly when his identity was recognized. We must give our thanks toThe Journalfor the fine descriptions published in 1963. I have also been told that he was in Springfield, Massachusetts, before.
The quiet revolution.
Journal: BMJ (1972)

severe than they could be.Policing is difficult-even impossible-with mass travel by car and small boats across the Channel.Only education and good sense can prevent irresponsible people from endangering us all.The immediate results of smuggling in a rabies-infected dog might be very similar to those described above, but the efficient measures so rapidly invoked in Vietnam would be put into effect more slowly and with greater difficulty in a civil than a military population.Veterinary surgeons need to be constantly aware of the possibility that a case of rabies may appear in their surgeries.Doctors, and particularly medical officers of health, would be well advised to keep themselves informed about the disease and make sure they have the rules for post-infection prophylaxis to hand.Enough vaccine and hyperimmune serum should always be available to treat a substantial num- ber of people at short notice.Because of the frequency of reactions after the administration of serum, the need for safe and effective hyperimmune globulin, preferably of human origin,7 must be emphasized.
Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration
Authors: Abhishek Jauhari, Sergei V. Baranov, Yalikun Suofu, Jinho Kim, Tanisha Singh, Svitlana Yablonska, Fang Li, Xiaomin Wang, Patrick Oberly, M. Beth Minnigh, Samuel M. Poloyac, Diane L. Carlisle, Robert M. Friedlander
Journal: Journal of Clinical Investigation (2021)
ADDRESS ON THE CHARACTER OF DR. EDWARD JENNER AND THE HISTORY OF HIS DISCOVERY OF THE PROTECTIVE VALUE OF VACCINATION.
Authors: N.S. DAVIS
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prescription Drug User Fee Statute Enacted
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal