tbuckley/cabot-search huggingface dataset:
The 1933 Year Book of Radiology. Diagnosis.
Journal: JAMA (1933)

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Burning feet.
Authors: H H Eastcott
Journal: BMJ (1976)

of ours who is in long-term remission after chemotherapy of acute myeloblastic leukaemia in childhood.He is now married and has two normal children.In September 1963, when aged 9 years, he was found to have acute myeloblastic leukaemia, was treated with prednisone and 6-mercaptopurine, and went into remission.He relapsed in January 1965 and was then treated with prednisone and methotrexate, achieving a further but short remission and relapsing in July 1965.This second relapse was treated with prednisolone and cyclo- phosphamide and was followed by complete clinical and haematological remission which has been maintained ever since.Treatment was stopped at the end of 1967.The patient married in 1972 and has a daughter aged 4 and a son aged 2 years, both clinically well.He was last seen (with his family) in June 1976 and found to be in continued haematological remission.Between her two normal pregnancies his wife had a miscarriage, but nothing is known about the condition of the fetus.
Use of Heating Pads Dangerous to Neonates
Journal: JAMA (1963)

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Diagnostic performance of contrast-enhanced CT for the diagnosis of portosinusoidal vascular disease: a case-control study
Authors: Shantha Valainathan, Pellegrino Silvia, Nivolli Arianna, Nicolas Drilhon, Lazareth Marie, Bruno Onorina, Aurelie Plessier, François Durand, Maxime Ronot, Dominique Valla, Valérie Paradis, Valerie Vilgrain, Pierre-Emmanuel Rautou
Journal: Journal of Hepatology (2020)
POLYMYOSITIS.
Journal: JAMA (1900)

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P091 (0159) SERUM sCD30 AND TARC DO NOT CORRELATE WITH PET‐BASED RESPONSE ASSESSMENT IN PATIENTS (PTS) WITH STAGE III OR IV CLASSICAL HODGKIN LYMPHOMA (cHL): PHASE 3 ECHELON‐1 STUDY OF BRENTUXIMAB VEDOTIN PLUS CHEMOTHERAPY VS CHEMOTHERAPY ALONE
Journal: HemaSphere (2018)
Diffuse Heterotopic Cystic Malformation of Stomach
Journal: JAMA (1963)

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STOKES OF DUBLIN (1804-1878)
Journal: JAMA (1962)

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Varied health risks confront physicians in former Yugoslavia's embattled areas
Authors: P. Gunby
Journal: JAMA (1994)

LAND MINES and vipers await the unwary in areas of the former Yugoslavia, and these are only two of the many threats to safety and health that challenge physicians who live there and US military medical personnel temporarily serving in that war-ravaged land. Land mines are taking a heavy toll today and doubtless will continue to claim victims for years to come. With the ebb and flow of battle, many of the maps and landmarks (indicating where the mines are buried) have been destroyed. Another danger in unpaved areas comes from<i>Vipera ammodytes</i>, the longnosed viper, which may envenomate when disturbed and whose venom is highly toxic if rarely fatal. Also to be found are<i>V berus</i>, the common adder, which is less likely to attack but whose venom is moderately toxic, and<i>V ursinii</i>, the field adder, which usually avoids human confrontation and has venom considered to be slightly
J. J., JR.
Authors: J. H. T.
Journal: JAMA (1961)

James Jackson, Jr., a talented pupil of Pierre Charles Alexander Louis, died less than 2 months after he began the practice of medicine in Boston at the age of 25.<sup>1</sup>The senior Jackson (1777-1868), a student of Sir Astley Cooper and the first physician of the Massachusetts General Hospital (1810-1837), expressed his affection for his son in memoirs that are as devoted in their sentiments as those of Lord Chesterfield. In the introduction to the volume published a year following the son's death, he noted that the history of his son's life was simple and could be told briefly. The memoir that I reviewed,<sup>1</sup>an acquisition of John Crerar Library, Chicago, was inscribed thus: "Presented to the Library of the Medical Institution of Yale College By Prof. J. Jackson." The date of acquisition was not noted. J. J., Jr., was born in 1810. He received the doctorate in
ASSOCIATION NEWS.
Authors: L. Duncan Bulkley
Journal: JAMA (1898)

<h3>Further Delay in Publication of Official Proceedings.</h3> 4East37,New York, June 21, 1898. <h3>To the Editor:</h3> —Your telegram is at hand in regard to the resolutions and report of Executive Committee. I was more than half sick at Denver and could not write up the proceedings of the Executive Committee; in my book of notes there was an immense mass, and so put the book and all in my trunk to do it here at home. The trunk got separated from me and only reached me just now, and I have been overwhelmed with accumulated work that I have not yet tackled it, but will do so at once, and send on the resolutions, etc., very shortly. In haste, yours sincerely,
From the Editor's Desk
Authors: George L. Fite
Journal: JAMA (1974)

George Solan, MD, of Borthfield, Ohio, observes that phenylephrine hydrochloride is the drug of choice for treatment of anaphylaxis in a patient taking phenothiazine, where epinephrine might cause a further paradoxical lowering of the blood pressure. The<i>restless legs syndrome</i>is often due to unrecognized food or chemical allergy, says Granville Knight, MD, of Santa Monica, Calif. In his personal case, chocolate was the offender, and he has uncovered perhaps two dozen additional similar cases due to different foods. Harry Zimmerman, MD, of Bronx, NY, asks how often a breast is removed unnecessarily because of the inaccurate, hurried readout of a frozen section made from a specimen taken during surgery. He has had this experience recently, and recalls the opposite example of two years ago when a "normal" frozen section was later proven abnormal in a fixed tissue specimen read 24 hours later. The Journal's Letters section routinely declines
JAMA Reference Directories
Journal: JAMA (1985)

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Abstract 5152: EMT cells increase the metastatic potential of neighboring carcinoma cells via non-canonical activation of GLI signaling through secretion of VEGF-C
Authors: Deguang Kong, Deepika Neelakantan, Hengbo Zhou, Michael T. Lewis, Heide L. Ford
Journal: Cancer Research (2019)

Abstract Breast cancer is a devastating disease that claims around 50 million lives per year worldwide, and almost all of these deaths result from metastatic disease rather than from primary tumor burden. Recent studies clearly demonstrate that there is significant intratumor heterogeneity in breast cancer, and that this heterogeneity contributes to malignant progression. Our laboratories previously demonstrated that breast cancer cells that had undergone an oncogenic epithelial-to-mesenchymal transition (EMT) could increase metastasis of neighboring cells via activation of non-canonical GLI transcription factor activity in a paracrine manner that is dependent on Six1 expression in the EMT cells. However, the mechanism by which these Six1-expressing EMT cells activate GLI signaling thereby imparting aggressive properties on neighboring cells remained unknown. Herein we describe the novel discovery that VEGF-C, which is transcriptionally upregulated by Six1, mediates paracrine non-canonical activation of GLI and resultant enhancement of metastatic properties in cells that do not express Six1. Our data demonstrate that VEGF-C is upregulated in HMLER-Snail1 cells, MCF7-Six1 cells and in Met-1 cells endogenously expressing Six1, in a manner that depends on Six1 expression, and that VEGF-C is secreted into the conditioned media (CM) of these cells. Inhibition of VEGF-C in the HMLER-Snail1, MCF7-Six1, and the Met-1 models abrogates paracrine GLI activation and attenuates non-cell autonomous induction of proliferation, migration, and invasion in vitro. In vivo, we show that cells expressing Six1 can enhance the growth and metastasis of those not expressing Six1, and studies will be discussed that examine whether VEGF-C inhibition in Six1 expressing cells disrupts the crosstalk and inhibits non-cell autonomous induction of metastasis by Six1. Finally, by interrogating the TCGA dataset we find that VEGF-C and GLI1 expression significantly positively correlate in human breast cancer encompassing all molecular subtypes. Taken together, these data suggest that VEGF-C secretion may be a novel and conserved paracrine means by which EMT cells activate GLI in neighboring tumor cells that do not express these EMT-inducing transcription factors (TF), ultimately enhancing overall metastasis of heterogenous breast tumors. Citation Format: Deguang Kong, Deepika Neelakantan, Hengbo Zhou, Michael T. Lewis, Heide L. Ford. EMT cells increase the metastatic potential of neighboring carcinoma cells via non-canonical activation of GLI signaling through secretion of VEGF-C [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5152.
Antagonists of Neuronal Calcium Channels: Structure, Function, and Therapeutic Implications
Authors: G. P. Miljanich
Journal: The Annual Review of Pharmacology and Toxicology (1995)

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More
Fetal alcohol syndrome: Report of a case
Authors: M. S. Tenbrinck
Journal: JAMA (1975)

A boy born to a known alcoholic mother demonstrated the fetal alcohol syndrome. Although considerably postterm, he weighed less than 1.5 kg (3 lb) at birth and has failed to catch up at 2 1/2 years of age. In addition to continuing prenatal and postnatal growth and developmental deficits, he has many of the other stigmata described as characteristic of this syndrome. To this list have been added other findings from our case. (<i>JAMA</i>232:1144-1147, 1975)
STANDARDIZED DRUGS.
Journal: JAMA (1996)

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A randomized trial of propranolol in patients with acute myocardial infarction. II. Morbidity results
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Some Thoughts on the Principles of Local Treatment in Diseases of the Upper Air Passages, Being Two Lectures at the Medical Graduates College and Polyclinic, on October 2 and 9, 1901. With an Appendix Consisting of Two Letters Published on November 23, 1901. and on January 11, 1902, in the British Medical Journal.
Journal: JAMA (1902)

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Dose-dense neoadjuvant treatment with biweekly docetaxel (T) plus epirubicin (E) for locally advanced breast cancer (LABC). An ONCOPAZ Cooperative Group Study
Authors: P. Borrega, A. Lorenzo, C. Madroñal, J. J. Sanz, M. Ruiz, M. Centelles, A. Casas, C. González de La Puente, V. Perez, M. González-Barón
Journal: Journal of Clinical Oncology (2004)

736 Background: Dose-dense chemotherapy may achieve superior clinical outcomes over conventionally administered chemotherapy in BC. The primary objective of this study was to evaluate the RR of biweekly T plus E in LABC (stage III). Secondary objectives were to determine pathological response rate, safety profile and the correlation between the expression of molecular markers (MM) and response. Methods: Patients with histologically or cytologically confirmed LABC, age ≥ 18 years, ECOG PS ≤ 2 and adequate bone marrow, hepatic, renal and cardiac functions were eligible. Prior chemotherapy, hormonal therapy or radiotherapy was not allowed. Patients with invasive bilateral BC were excluded. Treatment: E (75 mg/m2) and T (75 mg/m2) iv, every 14 days with G-CSF support for 6 cycles. Surgery was recommended 3–6 weeks after completion of chemotherapy. The expression of MM, such as ER, PR, HER-2 was assessed and correlated with clinical and pathological responses. Results: To date, 48 patients have been included. Median age was 51 (31–77), 98% had ECOG PS 0–1, tumor stage IIIA (41%) and IIIB (59%). MM expression was determined (ER+ 58%, PR+ 48%, HER-2+ 53%). A total of 262 cycles (median 6, range 1–6) was administered. Median RDI was 97% and 98% for T and E, respectively. All patients were evaluable for toxicity. Main grade 3/4 toxicities per patient were neutropenia (9%), leukopenia (9%), anaemia (4%). Febrile neutropenia was observed in 2 patients, 1 cycle each. Efficacy: Eight patients were not evaluable (1 missed evaluation, 3 dropped-out without evaluation and 4 still ongoing). Of 40 patients, 7 achieved CR (18%), 22 PR and 11 SD resulting in an ORR of 73% (95% CI: 59–86). Surgery was performed in 39 patients and 8% had complete pathological response. Logistic regression analysis suggested that neither hormone receptor status nor HER-2 status correlated with clinical response. Conclusions: Biweekly T plus E is an active and well-tolerated neoadjuvant regimen for patients with LABC and high expression of HER-2 (53%). No significant financial relationships to disclose.