tbuckley/cabot-search huggingface dataset:
Volkmann's ischemic contracture after intra-arterial injection of secobarbital
Authors: N. R. Morgan
Journal: JAMA (1970)

A clinical syndrome follows accidental self-administration of secobarbital intra-arterially. It is characterized by immediate, severe, burning pain radiating into the hand. Tense muscle edema and necrosis developed during 24 to 48 hours in the presence of an intact radial pulse. Confusion with cellulitis may delay accurate diagnosis. Early fasciotomy can prevent the development of Volkmann's ischemic contracture.
Continuing Medical Education
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
British Society for Skin Care in Immunocompromised Individuals
Authors: R Atkar, G Meligonis, S Hussain
Journal: British Journal of Dermatology (2015)

Bone marrow transplant recipients frequently develop rashes as a consequence of their disease, treatment, infection or graft-versus-host disease (GVHD).Skin biopsies are frequently used to confirm the clinical diagnosis of GVHD; however, interpretation can be difficult as histological changes in GVHD can be indistinguishable from other common causes, such as drug rashes.The objective of this study was to determine the value of a skin biopsy in the diagnosis and management of suspected cutaneous GVHD after allogeneic stem cell transplantation.The notes of 39 consecutive patients [28 men, 11 women; mean age 50 years (range 5-68)] who had a skin biopsy for suspected GVHD between December 2011 and August 2013 were retrospectively reviewed.The mean time of rash onset from date of bone marrow transplant was 92 days (range 1-10).The nature of the rash was eczematous in most cases (16 patients), but urticated (four patients), blistering eruptions (three patients), sclerodermoid and vasculitic presentations were also noted.Six patients were noted to have gastrointestinal symptoms at the time of the rash, all of whom were treated for GVHD.No patients had abnormal liver function tests, and one patient had a peripheral eosinophilia.In 21 patients, the skin biopsy showed features of interface dermatitis consistent with GVHD; however, only 17 cases were treated as such.The remaining four patients were treated as having a drug rash.In the remaining 18 patients, skin biopsy did not show any histological features of GVHD; however, 12 of these patients received treatment for GVHD and their rash resolved over 1 week to 1 year.Twenty-nine (74%) patients received treatment for GVHD.Four patients were managed with topical steroids alone.The majority of patients received a combination of topical and oral steroids along with an increase in their immunosuppressive regimen.Three patients were referred for extracorporeal photopheresis.Twenty-three of these patients had skin GVHD only and six had other evidence of organ involvement (gut GVHD).The diagnoses for 10 patients not treated for GVHD were drug eruptions (six cases), vaccine reaction (one case), cytomegalovirus reactivation (one case), leukaemia cutis (one case) and nonspecific rash (one case).Our results suggest that a clinical suspicion of GVHD is likely to prompt treatment, despite inconclusive histology.However, dermatology input and skin histology can be useful in offering other diagnoses, and excluding GVHD, as shown in a quarter of the cases reviewed.
Recurrent pancreatitis and fat-induced hyperlipoproteinemia
Authors: D. F. Cross
Journal: JAMA (1969)

<h3>To the Editor:—</h3> I cannot refrain from calling to your attention a typo which appears in the St. Patrick's Day or Salvador Dali issue ofThe Journal. As March moves rapidly towards April 15th, it is apparent that there are millions of people in this country, including authors and typesetters who could easily put down 1040 in place of almost any number you might mention. A particularly amusing concatenation is the characterization of it as "the late 1040's" (<b>207</b>:2080, 1969). In C. P. Snow's book,<i>Varieties of Men</i>, he reports a conversation between the great mathematician Hardy and a visitor concerning the immense wealth of information and inter-relationships tied up in what might appear to the nonmathematician as a simple number. If I were privy to the mode of entry into the "numbers" game in St. Louis, I would certainly put 25 or 50 cents down today on either
<i>Circulation</i> Editors’ Picks
Journal: Circulation (2013)

Thrombin is a key mediator of platelet activation in acute coronary syndromes.Atopaxar is a reversible protease-activated receptor antagonist that interferes with thrombin mediated platelet effects.The phase II Lessons From Antagonizing the Cellular Effect of Thrombin-Coronary Artery Disease (LANCELOT-CAD) trial examined the safety and tolerability of prolonged therapy with atopaxar in subjects with CAD.Seven hundred and twenty subjects were randomized in a double-blind fashion to 1 of 3 dosing regimens of atopaxar (50, 100, or 200 mg daily) or matching placebo for 24 weeks and followed up for an additional 4 weeks.Overall bleeding rates tended to be higher with atopaxar compared with placebo by Clopidogrel in Unstable Angina to Prevent Recurrent Events and Thrombolysis in Myocardial Infarction criteria without a difference in major bleeding by either category.All atopaxar regimens achieved high levels of platelet inhibition with dose-dependent rapid onset and offset.Major adverse cardiac events tended to be less frequent with atopaxar, but the trial was not powered for clinical events, and statistically significant differences were not observed.Atopaxar was generally well tolerated, but QTc prolongations and liver transaminase elevations without clinical sequelae were observed with higher-dose atopaxar.Although these data are encouraging, larger-scale trials are needed to determine the clinical efficacy and safety of protease-activated receptor-1 antagonism in patients with atherosclerotic vascular disease.Conclusions-In this dose-ranging study of patients with CAD, treatment with atopaxar resulted in platelet inhibition, more minor bleeding, and numerically but not statistically fewer ischemic events.Larger-scale trials are needed to determine whether these patterns translate into clinically meaningful effects.
Inductive effect on hepatic enzymes and toxicity of congeners of PCBs and PCDFs.
Authors: H Yoshimura, S Yoshihara, N Koga, K Nagata, I Wada, J Kuroki, Y Hokama
Journal: Environmental Health Perspectives (1985)

The present paper describes a marked induction of liver microsomal cytochrome P-450 and cytosolic DT-diaphorase to cause possible disorder of steroid homeostasis and promotion of carcinogenicity of 4-nitroquinoline N-oxide (4-NQO) in rats by pretreatment with 3,4,5,3',4'-pentachlorobiphenyl (PenCB) or 2,3,4,7,8-pentachlorodibenzofuran (PenCDF). The animals were sacrificed 5 days after the pretreatment. These induction experiments showed that 7 alpha-hydroxylation of both progesterone and testosterone in liver microsomes was selectively increased to a great extent, but hydroxylations at the 2 alpha-, 6 beta- and 16 alpha-positions were depressed, together with 5 alpha-reduction. From the same microsomes, three of the strongly induced P-450 isozymes, i.e., high- and low-spin P-448s and P-452, were purified. The last isozyme was most responsible for 7 alpha-hydroxylation of testosterone. The pretreatment, also increased activity of DT-diaphorase and reduction of 4-NQO about 10-fold in liver 9000g supernatants. This reduction of 4-NQO was solely catalyzed by DT-diaphorase and the only product was 4-hydroxylaminoquinoline N-oxide, a proximate carcinogen, indicating that the pretreatment strongly increased production of a proximate carcinogen from 4-NQO. Such an enhancement of the metabolic activation of 4-NQO by the pretreatment was also observed to some extent in the lung and the skin. Persistency of PenCB and PenCDF in the liver of rats was also discussed.
FATAL CATATONIA
Authors: OTTO BILLIG, W. T. FREEMAN
Journal: American Journal of Psychiatry (1944)

Fatal catatonia is considered a complication to the usual schizophrenic course. The syndrome may occur in cases of apparent health or show itself as an exacerbation during any form of schizophrenia. The heredobiologic and pathophysiologic mechanisms, and the clinical course prove that this syndrome does not represent a separate schizophrenic group but merely a complication. The symptoms are: A prodromal phase which lasts from 2 weeks to a few months and shows the usual schizophrenic pattern. First Phase.—Increasing perplexity and intense anxiety; incoherence; extreme restlessness; a "blind drive for annihilation" and suicidal tendencies; acrocyanosis, increased blood-pressure. Second Phase.—Motor restlessness changing to a more primitive pattern; consciousness becomes increasingly clouded; unusual hematopoietic changes of the blood; blood pressure falls; pulse is rapid and weak; pupils are dilated and react sluggishly to light; reflexes are decreased; high elevation of temperature; pronounced cyanosis; petechial hemorrhages into the tissue; sudden respiratory death or vasomotor collapse. Autopsy Findings.—Negative except for petechial hemorrhages into the tissues, and transformation of the fatty bone marrow to the erythropoietic state. A theory of possible "asthenic metabolic changes" due to disturbances in the hormonal-vegetative system, and its practical application were discussed.
Computed Tomographic Scanning of the Brain
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WOMEN NURSES IN MILITARY HOSPITALS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasound evaluation of pelvic pain
Authors: H. S. Vine
Journal: JAMA (1980)

A rapid examination method for female subjects with acute pelvic pain was developed for potential clinic or emergency distinction of medical and surgical disorders. A 95% diagnostic accuracy was achieved in separating retrospectively 102 consecutive patients into "hospital" or "outpatient" categories. It is recommended that ultrasound be used routinely in the initial evaluation of acute pelvic pain. The procedure complements and may be considered an extension of the traditional physical examination. (<i>JAMA</i>1980;244:2540-2542)
Erratum: Digenic inheritance of severe insulin resistance in a human pedigree
Authors: D B Savage, M Agostini, I Barroso, M Gurnell, J Luan, A Meirhaeghe, A-H Harding, G Ihrke, O Rajanayagam, M A Soos, S George, D Berger, E L Thomas, J D Bell, K Meeran, R J Ross, A Vidal-Puig, N J Wareham, S O'Rahilly, V K K Chatterjee, A J Schafer
Journal: Nature Genetics (2002)
Cardiology
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beta interferon treatment in chronic liver disease HCV related, study on 86 patients C. Paneila, D. Conte, M. Margiotta, R. Rubini, L. Tatulli, F.W. Guglielmi, V. Vinciguerra, A. Francavilla. Cattedra di Gastroenterologia, University of Bari, Bari, Italy
Journal: Hepatology (1993)
The carcinoid syndrome
Authors: P. N. Maton
Journal: JAMA (1988)

<h3>SELECTED CASE</h3> A WOMAN was well until the age of 54 years when she developed asthma, which was treated with albuterol and steroids. Two years later she noticed intermittent diarrhea and flushing. When first seen, five years after the onset of asthma, she gave a history of flushing of the upper part of her body, a 4.5-kg weight loss, and diarrhea. On examination at that time, she had an enlarged, irregular liver, a prominent flush over the upper half of the body, and a scaly erythematous rash on the face and hands that proved to be pellagra. The venous pressure was elevated 2 cm above the clavicle, and there was a third heart sound. Investigations showed an elevated serum alkaline phosphatase level of 180 U/L (normal level, &lt;124 U/L) with normal levels of bilirubin and transaminases. Fecal fats were 9 g/d (normal amount, &lt;7 g/d), and the concentration of 24-hour
United States Loses Lead in Contraceptive Choices, R&amp;amp;D; Changes in Tort Liability, FDA Review Urged
Authors: Teri Randall
Journal: JAMA (1992)

THE UNITED STATES has become the global backwater in contraceptive research and development, experts warn, and unless steps are taken now to change public policy related to contraceptive development, contraceptive choice in the next 10 to 15 years will not differ appreciably from what it is today. "The United States has gone from being the indisputable world leader in contraceptive research and development to become a third-world nation [in this regard]. We are very inept in helping families achieve the size that they want," says David Grimes, MD, professor of obstetrics and gynecology and preventive medicine at University of Southern California School of Medicine, Los Angeles. <h3>Industry Abandons Field</h3> Speaking at the annual meeting of the American College of Obstetricians and Gynecologists, held in Las Vegas, Nev, Grimes noted that during the last three decades, all but one major US pharmaceutical company—Ortho Pharmaceutical Corp, Raritan, NJ (a subsidiary of Johnson
HLA patterns and disease associations
Authors: S. E. Ritzmann
Journal: JAMA (1976)

The a priori biologic significance of the histocompatibility complex with its excessive polymorphism remains unknown. Teleologically, however, the role of the HLA system may be viewed as vital for survival of the species and the individual by providing the host with a recognition system of and defenses against viruses, microorganisms, parasites, plant antigens, neoplastic cells, and others. HLA testing, in addition to its usefulness in donor selection for transplantation, has been recently applied to the diagnosis and differentiation of specific diseases, the prediction of disease development (risk prediction), and as a basis for prognostic evaluations. An increasing number of diseases is being shown to be linked by specific HLA antigens and certain common denominators, such as arthritides, autoimmune components or infections, suggesting common etiologic or pathogenic mechanisms or both. These diseases with HLA associations can be separated into those that appear certain, probable, or only statistically possible. (<i>JAMA</i>236:2305-2309, 1976)
The Practical Importance of Well Established Facts in Therapeutics.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Afternoon Diabetes.
Authors: Angela J. Bowen
Journal: Annals of Internal Medicine (1967)

s1 May 1967Afternoon Diabetes.Angela J. Bowen, M.D., Robert L. Reeves, M.D., F.A.C.P., Robert L. Nielsen, M.D., F.A.C.P.Angela J. Bowen, M.D.Search for more papers by this author, Robert L. Reeves, M.D., F.A.C.P.Search for more papers by this author, Robert L. Nielsen, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1057_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiurnal variations in glucose tolerance have been studied in 1,429 subjects. From these studies it is apparent that at least three patterns of response exist.True Diabetes: These subjects have abnormal responses to oral glucose throughout the 24-hr cycle. They may or may not have a diurnal variation in the magnitude of response, but if present it is not of diagnostic significance. This group represented 5% of the total number studied.Normal:These people have minimal or no diurnal variations in their response to a glucose challenge. They have normal responses throughout the 24-hr cycle (49% of total group studied).... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUrea–Formaldehyde and Melamine–Formaldehyde PolymersObservations on morning and afternoon glucose tolerance: Differences between sexesThe value of afternoon glucose tolerance testing in the diagnosis, prognosis and rational treatment of �early chemical diabetes�. A five-year experienceTHE ROLE OF DIABETOGENIC HYPERINSULINISM IN NOCTURNAL ANGINA PECTORIS, WITH SPECIAL REFERENCE TO THE ETIOLOGY OF ISCHEMIC HEART DISEASE* 1 May 1967Volume 66, Issue 5Page: 1057-1058KeywordsGlucoseGlucose tolerance Issue Published: 1 May 1967 PDF DownloadLoading ...
Reversal of immune paralysis to immune homeostasis: effect of plasma exchange on monocyte merTK and HLA-DR expression in patients with acute-on-chronic liver failure
Authors: Siddharth Mittal, Meenu Bajpai, Pradeep Kumar, Ravinder Chaudhary, Gayatri Ramakrishna, Shiv Kumar Sarin, Nirupma Trehanpati
Journal: Journal of Hepatology (2020)
Hypoglycemia Associated with Symptoms in the Newborn
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal