tbuckley/cabot-search huggingface dataset:
Surgery of the Eye.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Appendix I
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: Implications for ammonia-induced brain edema
Authors: J Cordoba
Journal: Hepatology (1996)

Brain myo-inositol, an organic osmolyte, is decreased in cirrhotic patients with hepatic encephalopathy but appears unchanged in fulminant hepatic failure. An osmoregulatory response to the increase in brain glutamine may explain the decrease in brain myo-inositol; if this is the case, organic osmolytes may account for differences in the development of brain edema seen in acute or chronic liver failure. The response of myo-inositol and nine other organic osmolytes to the increase in brain glutamine at different time intervals after portacaval anastomosis (PCA) in the rat was studied. Organic osmolytes were measured in brain tissue and cerebrospinal fluid. Water in cerebral cortex was measured after ammonia infusion with the gravimetric method. Six weeks after PCA, despite an increase in brain glutamine (PCA, 16.4 +/- 2 mmol.kg wt-1.kg wt-1; sham, 5 +/- 1 mmol.L-1.kg wt-1), the content of total organic osmolytes did not increase (PCA, 44.1 +/- 3; sham, 43 +/- 4) because of a decrease of other osmolytes (myo-inositol, 54%; urea, 39%; taurine, 33%; and glutamate, 8%). Brain myo-inositol was lower at 3 weeks (3.4 +/- 0.5 kg wt-1) than at 1 day after PCA (4.7 +/- 0.5 kg wt-1). An ammonia infusion resulted in brain edema at both time points. In conclusion, the reduction in brain myo-inositol in PCA rats is accompanied by the decrease of other organic osmolytes, supporting the view that changes in myo-inositol reflect an osmoregulatory response. The decrease in brain myo-inositol is more marked as time elapses after PCA. In a model in which short-term and large doses of ammonia were infused, the decrease in brain myo-inositol did not prevent the development of brain swelling. Understanding brain osmoregulatory mechanisms may provide new insights into hepatic encephalopathy and brain edema in fulminant hepatic failure. (Hepatology 1996 Oct;24(4):919-23)
Europe’s largest meta-analysis on the prevalence of non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and advanced fibrosis (F3-F4)
Authors: Salvatore Petta, Hannes Hagström, Andreas Geier, Vlad Ratziu, Llorenç Caballeria, Carmen Expósito, Rosario Hernández, Hans Blokzijl, Robert De Knegt, Diogo Ferrinho, Ioanna Ntalla, Alan Smith, Heribert Ramroth, Philip N Newsome
Journal: Journal of Hepatology (2020)
Association Between Endothelin Receptor B Nonsynonymous Variants and Melanoma Risk
Authors: Nadem Soufir, Roubila Meziani, Jean-Jacques Lacapère, Guylene Bertrand, Frederic Fumeron, Agnes Bourillon, Bénédicte Gérard, Vincent Descamps, Béatrice Crickx, Laurence Ollivaud, Alain Archimbaud, Céleste Lebbe, Nicole Basset-Seguin, Philippe Saiag, Bernard Grandchamp
Journal: JNCI Journal of the National Cancer Institute (2005)

The endothelin signaling pathway plays a crucial role in melanocyte differentiation and migration. In this study, we investigated whether germline mutations of endothelin receptor B (EDNRB), a gene involved in Hirschsprung disease (HSCR), could also predispose for malignant melanoma (MM). The coding region of EDNRB was sequenced in 137 MM patients and in 130 ethnically matched Caucasian control subjects. Six nonsynonymous EDNRB variants were found in 15 patients (11%), but only two were found in four control subjects (3%, odds ratio [OR] = 3.87, 95% confidence interval [CI] = 1.25 to 12; P = .012). Overall, 14 out of 15 MM patients carried EDNRB mutations reported in HSCR, some of which had previously been shown to lead to loss of function. In multivariable logistic regression analysis including skin type, eye and hair color, number of nevi, and dorsal lentigines (freckles), the association between EDNRB mutations and MM risk remained statistically significant (OR = 19.9, 95% CI = 1.34 to 296.2; P = .03). Our data strongly suggest that EDNRB is involved in predisposition for two different multigenic disorders, HSCR and melanoma.
Plungers and polemics. Active compression-decompression CPR and federal policy
Authors: C. M. Olson
Journal: JAMA (1995)

<i>JAMA</i>has published a series of articles about active compression-decompression (ACD) cardiopulmonary resuscitation (CPR). The series began with a letter to the editor describing the use of a toilet plunger in a successful resuscitation.<sup>1</sup>This was followed by the description of a randomized crossover trial in only 10 patients that showed improved hemodynamic outcomes with ACD CPR.<sup>2</sup>In an accompanying critical editorial, Halperin and Weisfeldt<sup>3</sup>discussed ACD CPR and other novel resuscitation techniques. Last year we published the report of an underpowered randomized trial that found significant short-term improvement with ACD CPR among four of 44 subject-outcome groups analyzed, although no adjustments were made for multiple comparisons.<sup>4</sup>
Improvement of optic nerve head appearance after surgery for pseudotumor cerebri
Authors: E. L. Berman
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Parvovirus B19 quiescence during the course of human immunodeficiency virus infection in persons with hemophilia
Authors: James J. Goedert, Dean D. Erdman, Barbara A. Konkle, Thomas J. Török, Michael M. Lederman, Dorothy Kleinert, Titica Mandalaki, Craig M. Kessler, Larry J. Anderson, Naomi L.C. Luban
Journal: American Journal of Hematology (1997)
Erratum
Journal: BMJ (1920)

paper on menstruation dcuring school life in the BRITISH XNIEDICAL JOUIRNAL of October 2nd, 19-0, anid Dr. --aftrv And rews's note in thie nlext isgue whlerein shie sai s:-T1h1T0ough a inatural fIisctioin, imienstruiatiou is a temporarydraini on a girls -vital energy, and it calls for special care."I quite gfree witlh her.an1d dlo not wonder at the folly of the atlhletic girl wlo went ini for v-iolenlt exercise during lher early courses uJf menstruationi now paying, the penalty for those excesses.This reminds miie of a very goodlprinciple we Indians have in Inidia.As a rl11e, including us Parsis, there is a custonm that lno girl or wosnian should( do anyheavy work, even (lomestic work, for at least thiree days-s during her course, and is b)idden to rest, by isolation in a separate -room and be(l.W'itlh us Parsis the good old ortlhodlox way was tb enjoin her not to touchi anyvbod-y, Inot even furniture, clothes, etc., save *i-e!al titensils.Slje is given a separate glass bowl and tray for lher meals and has to occupy a room downstairs specialiv kept for the purpose.This was enjoinie(d as a strict religious lbehest up till now; and the principle was good, as it gave her goo(d rest and.kept her to herself in a waiy.Any-thiing or ainy-
Lung sounds.
Authors: J Earis
Journal: Thorax (1992)

Lung soundsIn 1819, on the basis of observations with his newly invented stethoscope, Laennec published L'Auscultation Mediate.'In this masterly thesis he described and classified all the major lung sounds and suggested how they might correlate with lung abnormalities.Within three years the Scottish physician John Forbes translated Laennec's thesis into English' and by the end of the nineteenth century the subjective analysis of lung sounds was well established in that the stethoscope had become the hallmark of the physician.Detailed investigation of sound waveforms was impossible until the development of analogue electronics.In the 1960s Paul Forgacs used simple microphones, amplifiers, oscilloscopes, and tape recorders to obtain the first systematic measurements of respiratory sounds.His
Clinical cross-reactivity between amoxicillin and cephadroxil in patients allergic to amoxicillin and with good tolerance of penicillin
Authors: J. Sastre, L.-D. Quijano, A. Novalbos, G. Hernandez, J. Cuesta, M. de las Heras, M. Lluch, M. Fernandez
Journal: Allergy (1996)
Tuberculosis, PovertyTuberculosis, Poverty
Authors: Carlos Franco-Paredes
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Single-Donor, Marginal-Dose Islet Transplantation in Patients With Type 1 Diabetes—Correction
Authors: Peter Breese, William Burman
Journal: JAMA (2005)

institution.It is possible that the patient population of some institutions differs from the surrounding population in important ways.Despite these limitations, our study demonstrates that notices of privacy practices are lengthy and contain complex language that is unlikely to be understood by a considerable proportion of the populations served by topranked US health care institutions.If the purpose of the HIPAA legislation is to improve communication between patient and clinician, the documents used to do so need to be changed.
South African J Obstet Gynec, Cape Town
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized Trial of 30 Versus 20 Gy in the Adjuvant Treatment of Stage I Testicular Seminoma: A Report on Medical Research Council Trial TE18, European Organisation for Research and Treatment of Cancer Trial 30942 (ISRCTN18525328)
Authors: Roscoe Chan
Journal: Journal of Clinical Oncology (2005)

February 20 issue of the Journal of Clinical Oncology, in which they defined the appropriate radiation dose in the adjuvant treatment of stage I seminoma.It was a well done randomized trial, which tried to answer several important questions in the treatment of seminoma.Nearly 90% of the patients in the study received para-aortic strip only irradiation (PAS), without treatment to the pelvis.With reference to Table 3 of their article, I have several questions and comments.The recurrence pattern is very interesting to look at, even though it is for a small number, which has its limitations.Six (60%) of the 10 recurrences in the 30-Gy group were in the pelvic nodes, whereas three (27%) of 11 in the 20-Gy group were in the pelvic nodes.The locations of the pelvic nodes recurrences were not mentioned, so we could not see whether these recurrences could potentially have been prevented by the use of the dogleg (DL) field.If we accept the conclusions of the study, ie, 20 Gy is as effective as 30 Gy, and then we retrospectively look from the treatmentfield perspective, only 1/5 of the recurrences in the DLtreated patients was in the pelvic nodes, whereas for eight of 16 patients in the PAS-treated group the recurrences were in the pelvis.The difference in the abdominal recurrences in both groups is not as dramatic (DL, one of five; PAS, three of 16).That is as far as what can be dissected out from these data on such a small number of events.However, the data suggest (1) 20 Gy versus 30 Gy is about the same in preventing para-aortic recurrences; (2) the addition of pelvic radiation may reduce pelvic node recurrences (if these recurrences were in the potential DL fields).If that is the case, the patients in the 30-Gy group may actually have a lower overall recurrence rate (four nonpelvic-node recurrences) compared with the 20-Gy group (eight nonpelvic node recurrences), which in turn may change the overall results in the trial.This certainly opens up another can of worms in term of considering the need of using the DL field again for the treatment of stage I seminoma for doses like 20 Gy.I hope the authors can address my concerns.
Prevalence of MBL Increases Over Time In Relatives of CLL Families,
Authors: Susan L Slager, Mark C Lanasa, Sallie D. Allgood, Sara J Achenbach, Aaron Norman, Celine M Vachon, Lynn Goldin, Jose F. Leis, Neil Kay, J. Brice Weinberg, Kari Rabe, Timothy G. Call, James R Cerhan, Tait D. Shanafelt, Neil E Caporaso, Gerald E Marti, Curtis A. Hanson
Journal: Blood (2011)
Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
First Step
Authors: Chelsea Sprick
Journal: Annals of Internal Medicine (2015)

Ad Libitum3 November 2015First StepChelsea SprickChelsea SprickFrom Milwaukee, Wisconsin.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-1355 Audio Reading - “First Step” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "First Step," by C. Sprick. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail They told me about owl eyes and dewdropson rose petals. Beautiful wordsscrawled across whiteboardslike a migration of blackbirds.Even in dark rooms, I could see birdbeaks and steeples.Before I took his leg, he told me his recipefor fish stew: carrots, potatoes, white bass.The beauty of their words reassured me—soleus brought images of vein-gnarled handsexpertly running a fillet knife along backbones.Silver scales slipping away from pearly muscle.balancing a paper crane on ... Author, Article, and Disclosure InformationAffiliations: From Milwaukee, Wisconsin.Current Author Address: Chelsea Sprick; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “First Step” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "First Step," by C. Sprick. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 3 November 2015Volume 163, Issue 9Page: 720KeywordsBreathingCellsChildrenHand strengthMusclesRunningSleep ePublished: 3 November 2015 Issue Published: 3 November 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clinicopathological features and treatment outcomes of young patients with gastric and esophageal cancers.
Authors: Lauren Amanda Beck, Lucy Xiaolu Ma, Osvaldo Espin-Garcia, Chihiro Suzuki, Di Maria Jiang, Geoffrey Liu, Eric Xueyu Chen, Jennifer J. Knox, Rebecca Wong, Savtaj Singh Brar, Carol Jane Swallow, Jonathan Yeung, Gail Elizabeth Darling, James Conner, Elena Elimova, Raymond Woo-Jun Jang
Journal: Journal of Clinical Oncology (2020)

325 Background: Gastric and esophageal (GE) cancers most commonly occur in older adults in their 60’s. There are inconsistent reports about prognosis in adolescent and young adult (AYA) pts, and treatment patterns and outcomes in this population have not been well characterized. Methods: A retrospective analysis was performed for AYA (age &lt; 40) pts with GE cancers who presented to Princess Margaret Cancer Centre from 2008 to 2016. The Kaplan-Meier method was used to analyze progression free (PFS) and overall survival (OS). Results: We identified 57 AYA GE cancer pts (30 gastric, 27 esophageal). Features at diagnosis included: median age 35, 51% female (70% in gastric, 30% in esophageal), 82% with performance status 0-1, 83% Charlson Comorbidity Index 0, 54% stage IV. For gastric pts, 53% had diffuse histology and 47% had signet ring adenocarcinoma. There was a negative family history of gastric or esophageal cancer in 77% of pts. Curative intent treatment was used in 23 pts, palliative in 34. In curative pts, 48% had neoadjuvant therapy, 52% had upfront surgery. Of pts who underwent surgery, 57% had T3 or T4a disease and 38% had N2 or N3 disease. Median OS in curative pts was 39.9 months (95% CI 19.7-69.9), with a 5-year OS rate of 37% (95% CI 20-67). Of the palliative pts, 91% had chemotherapy. First line chemotherapy was a triplet regimen in 80%, doublet in 13%. The median number of treatment cycles on first line chemotherapy was 6, with a median PFS of 7.4 months (95% CI 5.4-10.5). At progression, 14 pts had second line treatment, 3 pts had third line and only 1 pt was treated beyond third line. Median OS in palliative pts was 12.1 months (95% CI 8-21.3). Conclusions: Consistent with the literature, our gastric AYA pts had increased female predominance and diffuse histology. Many AYA pts had advanced disease at diagnosis, with over half of pts presenting with metastatic disease. In both the curative and palliative setting, AYA pts did not have better survival outcomes despite being young with few comorbidities, suggesting they may have more aggressive biology.