Lymphocytic Hypophysitis
Authors: DUNCAN J. TOPLISS
Journal: Annals of Internal Medicine (1981)

Editorials1 August 1981Lymphocytic HypophysitisDUNCAN J. TOPLISS, M.B., B.S., ROBERT VOLPÉ, M.D.DUNCAN J. TOPLISS, M.B., B.S.Search for more papers by this author, ROBERT VOLPÉ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-2-227 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEndocrine glands are particularly likely to be affected by organ-specific autoimmune disease. Thyroid autoimmune disease, for instance, is well recognized and common. Autoimmune disease of the anterior pituitary, however, is little known and appears to be rare. Nevertheless, there is strong pathologic evidence of its existence; commencing with the report of Goudie and Pinkerton (1) in 1962 of lymphocytic hypophysitis seen at autopsy in a young woman with Hashimoto's thyroiditis, there are now seven reported cases with histologic observations.In this issue Asa and her colleagues (2) report two further cases, with ultrastructural evidence supporting an autoimmune basis for the...References1. GOUDIEPINKERTON RP. Anterior hypophysitis and Hashimoto's disease in a young woman. J Pathol Bacteriol. 1962;83:584-5. CrossrefMedlineGoogle Scholar2. ASABILBAOKOVACSJOSSEKREINES SJKRK. Lymphocytic hypophysitis of pregnancy resulting in hypopituitarism: a distinct clinicopathologic entity. Ann Intern Med. 1981;95:166-71. LinkGoogle Scholar3. MAYFIELDLEVINEGORDONPOWERSGALBRAITHRAWE RJLJRS. Lymphoid adenohypophysitis presenting as a pituitary tumor. Am J Med. 1980;69:619-23. MedlineGoogle Scholar4. WITEBSKYROSETERPLANPAINEEGAN ENKJR. Chronic thyroiditis and antoimmunization. JAMA. 1957;164:1439-47. CrossrefMedlineGoogle Scholar5. BOTTAZZOPOUPLARDFLORIN-CHRISTENSENDONIACH GAAD. Autoantibodies to prolactin-secreting cells of human pituitary. Lancet. 1975;2:97-101. CrossrefMedlineGoogle Scholar6. BOTTAZZODONIACH GD. Pituitary autoimmunity: a review. J R Soc Med. 1978;71:433-6. CrossrefMedlineGoogle Scholar7. BOTTAZZOMCINTOSHSTANFORDPREECE GCWM. Growth hormone cell antibodies and partial growth hormone deficiency in a girl with Turner's syndrome. Clin Endocrinol (Oxf). 1980;12:1-9. CrossrefMedlineGoogle Scholar8. BOTTAZZOVANDELLIMIRAKIANDONIACH GCRD. Autoantibodies to single endocrine cells in pituitary pancreas and gut. In: CUMMING IA, FUNDER JW, MENDELSSOHN FAO, eds. Endocrinology 1980. Canberra: Australian Academy of Science; 1980:95-9. Google Scholar9. DONIACH I. Histopathology of the anterior pituitary. Clin Endocrinol Metab. 1977;6:21-52. CrossrefMedlineGoogle Scholar10. ENGELBERTHJEZKOVA OZ. Autoantibodies in Sheehan's syndrome. Lancet. 1965; 1:1075. Letter. CrossrefMedlineGoogle Scholar11. TRIPLETT E. On the mechanism of immunologic self recognition. J Immunol. 1962;89:505-10. MedlineGoogle Scholar12. LEVINE S. Allergic adenohypophysitis: new experimental disease of the pituitary gland. Science. 1967;158:1190-1. CrossrefMedlineGoogle Scholar13. FROELICHGOODWINBANKHURSTWILLIAMS CJAR. Pregnancy, a temporary fetal graft of suppressor cells in autoimmune disease? Am J Med. 1980;69:329-31. MedlineGoogle Scholar14. GARSENSTEINPOLLAKKARK MVR. Systemic lupus erythematosus and pregnancy. N Engl J Med. 1962;267:165-9. CrossrefMedlineGoogle Scholar15. TOZMANUROWITZGLADMAN EMD. Systemic lupus erythematosus and pregnancy. J Rheumatol. 1980;7:624-32. MedlineGoogle Scholar16. FINEBARNETTDANOVITCH LEG. Systemic lupus erythematosus in pregnancy. Ann Intern Med. 1981;94:667-77. LinkGoogle Scholar17. GOUSTMOULIASREINERTDEVILLECHABROLLEBERTHAUX JRPAP. L'immunité cellulaire envers les antigènes d'organe au cours des affections endocriniennes: étude par le test de migration des leucocytes. Rev Fr Endocrinol Clin. 1972; 13:401-11. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Endocrinology Research Laboratory University of Toronto Toronto, Ontario Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrimary Hypophysitis: Idiopathic Inflammatory Disorders of the Pituitary GlandLymphocytic hypophysitis in a patient with Graves’ diseaseAcute loss of vision during pregnancy due to a suprasellar massHipofisitis granulomatosaLymphocytic AdenohypophysitisSelf-pituitary grafts are not rejected by frogs deprived of their pituitary anlagen as embryos 1 August 1981Volume 95, Issue 2Page: 227-229KeywordsAutoimmune diseasesAutopsyEndocrine physiologyThyroid Issue Published: 1 August 1981 PDF downloadLoading ...