tbuckley/cabot-search huggingface dataset:
The autoimmune diseases
Authors: J. J. Condemi
Journal: JAMA (1987)

ALTHOUGH this chapter is entitled "The Autoimmune Diseases," one can see that the diseases in which autoimmune phenomena contribute to pathogenesis are spread throughout this<i>Primer</i>. Since the earliest descriptions of the immune system, the ability of an individual to react to a wide variety of foreign insults, such as microorganisms and parasites, and internal changes, such as cancer cells, while not responding to one's own self, has intrigued researchers and is now attracting the attention of the clinician. Clinicians are interested because they encounter an increasing number of diseases and a wide range of clinical situations in which autoimmune phenomena apparently contribute to the symptoms. Clinical interest has been stimulated further by the therapeutic interventions that are now available or will be available in the near future to restore the function of the immune system to its major role in the prevention rather than production of disease. As early
THE CALL TO TEACH.
Journal: JAMA (1900)

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THE ROLE OF THE BODY FLUIDS IN PHAGOCYTOSIS.
Journal: JAMA (1904)

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WASHINGTON LETTER.
Authors: None R.
Journal: JAMA (1889)

Materia Medica Department of the National Museum. No visitor to the National capital interested in pharmacology should neglect to see the materia medica collection to be found in the south-west corner of the National Museum. The more liberal minded of our profession do not hesitate to acknowledge the truth that Dr. Oliver Wendell Holmes has enunciated with such forcible brevity in regard to the misfortune that would befall the fishes and the benefit that would accrue to mankind, in case all medicines, with but few exceptions, were sunk in the sea; but as the effect of age with a certain amount of misfortune and sickness are incident to all pursuits and conditions of life, it is the part of wisdom to try to deaden their blows. Perhaps in no department of life have human foresight and human wisdom been more exercised than in finding remedies for the various ills of
The Ambulance
Authors: Arthur G. King
Journal: JAMA (1978)

Not since 1869 has there been any comprehensive review of the development of the ambulance. Now, Katherine Barkley has collected pictures and descriptions of various methods of moving the sick and injured to hospitals, whether civilian or military. More than 150 illustrations do more than words to show the advance of techniques from ancient handcarries to mobile emergency units. The reader is amazed at the variety of animals and vehicles. Horses, mules, and camels either supported ingenious litters or pulled two-, three-, or four-wheeled carts. These were supplanted, except in mountainous areas, by automobiles (electric- or gasoline-powered), streetcars, and railroad cars, modified to care for from one to 60 invalids. Motor launches, river steamers, and oceangoing vessels were adapted or built specifically for the same purpose, and since 1930 the airplane and 1950 the helicopter gave tremendous extension to the 2,000-year history of getting the patient to a hospital or
ELECTRIC POSSIBILITIES.
Journal: JAMA (1904)

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Endometriosis
Authors: D. B. Redwine
Journal: JAMA (1986)

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Lord Lister.
Journal: JAMA (1925)

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Surgical Patients Acquire HCV
Journal: JAMA (2015)

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MD-aided suicide voted down; both sides say debate to continue
Journal: JAMA (1991)

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VADE MECUM
Journal: JAMA (1963)

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Reply
Authors: Jin‐Kyu Park, Yasuko Iwakiri
Journal: Hepatology (2017)

Potential conflict of interest: Nothing to report. Author names in bold designate shared co‐first authorship. We thank Yang and Rao for their interest in our recently published article.1 This is our reply to their questions on M2 polarization in endoplasmic reticulum (ER) stressed macrophages and the role of C/EBP homologous protein (CHOP) in this process. In our article, we inferred that reduced hepatic steatosis and injury in response to ethanol in the absence of Nogo‐B may be attributable, in part, to ER stress‐mediated M2 polarization of Kupffer cells based on our collective data and the existing literature. Other studies have also reported ER stress‐mediated M2 polarization,2 including M2 polarization by chemically induced ER stress in the presence of lipopolysaccharide similar to that used by us2 along with CHOP's involvement in this process.2 The effect of ER stress on macrophage polarization may be affected by the levels of ER stress (low vs. high, or acute vs. chronic), types of macrophages, and other experimental conditions. M2 polarization induced by higher levels of ER stress was shifted toward M1 polarization by lower levels of ER stress in a previous study.2 We induced ER stress in a murine macrophage cell line by tunicamycin (TM) (2 μg/mL for 24 hours),1 which is a stronger and longer TM treatment than the one used by Rao et al. (1 μg/mL for 6 hours in bone marrow–derived macrophages).5 These differences in experimental conditions may have contributed to the different results between the two studies. In our article, we also mentioned mechanisms other than ER stress that may modulate Nogo‐B's involvement in M2 polarization and highlight the need for further investigation.1 Advances in macrophage characterization beyond simple M1 and M2 phenotypes also add complexity and leave no doubt that the role of ER stress in macrophage polarization/differentiation needs to be scrutinized.
Molecular, cellular, and pharmacological characterization of beta-selective partial agonists of human thyroid hormone receptor for the treatment of non-alcoholic steatohepatitis
Authors: Jerome Deval, Sarah Stevens, Xuan Luong, Andreas Jekle, Tse-I Lin, Kusum Gupta, Dinah Misner, Sushmita Chanda, Jyanwei Liu, Caroline Williams, Antitsa Stoycheva, Leonid Beigelman, Julian Symons, Pierre Raboisson, Koen Vandyck
Journal: Journal of Hepatology (2020)
Highlights
Journal: JAMA Neurology (2016)

Fang and coauthors describe a novel IgG autoantibody found in serum or cerebrospinal fluid that is specific for a cytosolic intermediate filament protein of astrocytes.The frequency and definition of the novel autoantibody, the autoantigen's immunochemical identification, clinical and magnetic resonance imaging correlations of the autoantibody, and immunotherapy responsiveness were the main outcomes and measures.It was found that glial fibrillary acidic protein-specific IgG identifies a distinctive, corticosteroid-responsive, sometimes paraneoplastic autoimmune meningoencephalomyelitis.
Surgery Of The Rectum for Practitioners.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstracts
Journal: Annals of the Rheumatic Diseases (1970)

This paper describes a cooperative study started in 1956 by the Heart Disease Control Branch of the Public Health Service and the American College Health Assoc- iation, in order to determine the prevalence of a history of rheumatic fever or rheumatic heart disease or both amongst college freshmen.The data for 1956 to 60 have already been published: this paper presents the data for the completed 10-year period until 1965.The Survey, which covers 767,600 participants, is based upon a questionnaire completed by each freshman- average age 18 years.All case histories suggestiveof apast rheumatic infection are further investigated and the patient is examined medically although not in most cases by a trained cardiologist.From the final analysis it would appear that 15 * 8 per 1,000 students examined had a valid history of rheumatic fever or rheumatic heart disease or both-the incidence being highest in the Rocky Mountain States.Most of those who had suffered from these conditions during recent years had been recommended prophylactic medication, although only 55 per cent.had received it.The percentage who were maintaining prophylaxis during the period of the survey appeared to be largely determined by the number of attacks they suffered, but only 37 per cent. of those with four or more attacks continued to maintain prophylaxis.A higher percentage of females maintained prophylaxis than males, and a larger pro- portion of those for whom oral penicillin was prescribed maintained such treatment than did those given other types of medication.This study points the need for increased educational efforts amongst both the medical profession and the public towards the need to maintain prophylaxis in these rheumatic conditions.
Correction
Journal: BMJ (1950)

investigations, and if these are not available the problem becomes difficult.In such circumstances, if it is impracticable to transfer the patient to a centre where appropriate facilities are available, treatment should err on the side of caution.Thus in the case mentioned-though a definite opinion cannot be given because of the lack of information about the age of the patient, presence or absence of synovial thickening, local increase of temperature, movements, etc.-caution would suggest that the lesion be regarded as inflammatory and that treatment should be by-resting the knee in a plaster case, from groin to ankle, for an initial period of at least six to eight weeks.Subsequently, if improvement in the local condition is appar- ent, a clinical trial out of plaster, with intensive quadriceps redevelopment exercises, should be advised; but should further signs of inflammatory reaction occur further rest may be required.In each individual case the programme to be adopted depends so much upon the clinical state and progress of the condition that it is not possible, in a short answer, to lay down any more definite plan of treatment., Peribuccal Pigmentation Q.-A girl of 16, otherwise healthy, complains of brown pigmentation on either side of the upper lip.There is also some pigmentation of the brow.I should be grateful for suggestions about treating or bleaching the affected areas.
Nuclear medicine in the evaluation of the patient with jaundice
Authors: H. Handmaker
Journal: JAMA (1975)

THE DEVELOPMENT of radiopharmaceuticals that localize within the hepatobiliary system has facilitated evaluation of many difficult clinical problems, particularly differentiation between surgical and medical jaundice. In 1909, Abel and Rountree found that certain phenolphthalein dyes were excreted almost exclusively by the biliary system, and developed a clinical test of liver function based on measurement of fecal excretion of the dye. Sulfobromophthalein was later found to be superior to the other dyes for hepatic-clearance study, and in 1923 rose bengal was introduced by Delprat as a possible alternative. With use of fluorescent techniques, Mendeloff showed that stable rose bengal concentrated only in the polygonal cells and not in the reticuloendothelial cells. This knowledge led to Taplin's labeling of rose bengal with iodine 131, and permitted detection and imaging of the labeled dye as it was cleared from the blood, localized in the hepatocytes, and excreted into the bile en route to
PLANT PATHOLOGY AND MEDICINE
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal