tbuckley/cabot-search huggingface dataset:
Arzneiverordnungsbuch der Deutschen Arzneimittelkommission mit einer Auswahl bewährter Arzneimittel. Fifth edition.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Childhood lead poisoning. The impact of prevention
Authors: S. Binder
Journal: JAMA (1993)

Exposure of children to lead remains a pervasive problem in the United States. The US Environmental Protection Agency estimates that in 1990 approximately 3 million children in the United States had blood lead levels high enough to affect intelligence and development (whole blood lead level ≥0.48 μmol/L [10 μg/dL]).<sup>1</sup>The residential use of lead-based paint was prohibited in 1978,<sup>2</sup>and lead use in gasoline has decreased dramatically since the early 1970s.<sup>3</sup>Nevertheless, approximately 74% of all housing units built before 1980 contain lead-based paint,<sup>2</sup>and dust and soil heavily contammated by lead-based paint or leaded gasoline used in the past are found throughout the country.<sup>1</sup> The results of the two studies on lead published in this issue of<i>JAMA</i><sup>4,5</sup>make important contributions to our understanding of the impact of secondary prevention—the identification of and treatment for children with blood lead levels of public health
Acetone and Acetone Bodies in Serum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clustering of Chromosomal Aneuploidy and Tracing of Nondisjunction in Man
Authors: I. Hansmann
Journal: Environmental Health Perspectives (1979)

Chromosomal aneuploidy is the most frequent genetic damage observed in newborn children and originates as a rule from nondisjunction during maternal or paternal germ cell development. The error of chromosome segregation could be allocated in the past--at least in cases of 47,XXY--to maternal meiosis I (50%) or meiosis II (10%) and to paternal meiosis I (40%). Recent cytological improvements with various banding techniques enabled a further study on the origin of nondisjunction. Summarizing the published data one can argue that errors in Downs' syndrome are most often due to cleavage errors during maternal meiosis I. Approximately 70% of errors occur in oogenesis and only 30% in spermatogenesis. Maternal meiosis I seems also to be involved in most cases of fetal trisomy 16. Such a preferential missegregation of chromosomes offers the possibility of studying more closely the very mechanisms of nondisjunction in mammalian meiosis and early cleavages.
Boerhaave's Syndrome
Authors: Eugene A. Zenone
Journal: JAMA (1977)

Although Boerhaave's syndrome is usually a surgical emergency, we recently observed a 57-year-old man with a chronic Boerhaave's syndrome. Initially, he responded to conservative management. However, the spontaneous formation of an esophageal-bronchial fistula complicated his course. Pulmonary symptoms and weight loss prompted surgical intervention. We speculate that the patient's six-week clinical course before surgery was tolerated because the contamination of the mediastinum following the initial esophageal tear was well contained and allowed sufficient time for the spontaneous formation of an esophageal-bronchial fistula. (<i>JAMA</i>238:2048-2049, 1977)
GUAYAQUIL
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ANNUAL HOSPITAL ACCOUNTING.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Office Urology With a Section on Cystoscopy
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term effects of conservation therapy for muscle invasive bladder carcinoma
Authors: P. Chung, M. Gospodarowicz, P. Warde, Y. Qi-Long, M. Jewett, M. Milosevic, R. Bristow, M. Moore, I. Tannock, M. McLean
Journal: Journal of Clinical Oncology (2004)

4519 Background: A review of outcomes of radiotherapy-based bladder conserving therapy in patients with muscle invasive bladder cancer was performed to assess the long term outcomes. Methods: Of 131 patients with T2/T3aN0M0 (TNM 1992) transitional carcinoma of the bladder managed at Princess Margaret Hospital between 1986 and 1997, 108 were treated with radiotherapy alone, 20 with radiotherapy plus concurrent cisplatin and 3 with neoadjuvant chemotherapy plus radiotherapy. Response was assessed with cystoscopy 6 weeks after completion of treatment. Salvage cystectomy was offered as appropriate to patients who failed to achieve CR or relapsed locally (32% were considered unfit for surgery). Results: Overall CR rate was 72.5%. Overall survival (OS), cause specific survival (CSS) and local relapse free rates (LRFR) at 5 years were 44%, 58% and 49% respectively. For 95 patients that achieved CR, LRFR at 5 and 10 years was 59% at median follow up of 4.8 years (0.7–15.7). Of 47 patients with recurrent disease, 31 relapsed in the bladder only, 3 in bladder and pelvis, 2 in bladder and metastases, and 10 with metastases only. Salvage treatment for those with bladder only relapse (n=31) consisted of TUR/intravesical BCG in 52% (n=16) and cystectomy in 31% (n=11). Cumulative relapse rate was 42% at 3 years and 53% at 5 years; only 1 patient relapsed after 5 years. Those unfit for surgery had lower OS (p<0.01) and CSS (p=0.04). Prognostic factors for improved CSS and LRFR included absence of CIS, small primary tumor (≤2cm); patients who received chemotherapy had improved CSS. Only 19 of 131 pts had cystectomy for failure of local control. Conclusions: RT based treatment of locally advanced bladder cancer results in bladder preservation in the majority of patients with T2-T3a N0M0 (TNM 1992) bladder cancer. For patients who achieve CR, relapse beyond 5 years is uncommon. For select patients bladder conservation therapy with multimodality approach is an alternative to radical cystectomy. No significant financial relationships to disclose.
Phase II HEPANOVA trial of tumor treating fields concomitant with sorafenib for advanced hepatocellular carcinoma.
Authors: Anca Grosu, Eleni Gkika, Thomas B. Brunner, Robert Thimme, Uri Weinberg
Journal: Journal of Clinical Oncology (2019)

TPS470 Background: Tumor Treating Fields (TTFields) are a non-invasive, regional antimitotic treatment modality, which has been approved for the treatment of glioblastoma by the FDA. TTFields predominantly act by disrupting the formation of the mitotic spindle during metaphase. TTFields were effective in multiple preclinical models of hepatocellular carcinoma (HCC), leading to a significant increase in cell death. The Phase 2 HEPANOVA study is the first trial testing TTFields in HCC patients, and is designed to test the safety and efficacy of adding TTFields to sorafenib in advanced HCC. Methods: Patients (N = 25) with unresectable HCC who are not amenable to any local treatment will be enrolled in this prospective, single-arm study. The study enrolls patients with ECOG score of 0-2 and Barcelona clinic liver cancer (BCLC) stage 0-C. Patients must have a measurable disease per RECIST Criteria. Having implanted electronic devices in the torso is exclusionary. Sorafenib will be administered at standard dose (400 mg twice daily). TTFields (150 kHz) will be delivered for 18 hours/day until local disease progression per RECIST Criteria. Clinical follow up will be performed q4w, and a CT/MRI scan q12w. Following disease progression in the liver, patients will discontinue TTFields and be followed monthly for survival. Overall response rate will be the primary endpoint and in-field control rate, progression-free survival rate at 12 month (PFS12), OS rate at 1 year and toxicity will all be secondary endpoints. Sample size was calculated using an Exact test for proportions considering the weighted average of ORR of patients who had either complete or partial response per RECIST criteria in historical studies with sorafenib is 4.5%. A sample size of 25 patients was required to achieve a power of approximately 80% at a one-sided alpha level of 0.05 using a single sample Exact test for proportions. Clinical trial information: NCT03606590.
Association News
Authors: Frank Billings
Journal: JAMA (1923)

<h3>ANNUAL MEETING OF JUDICIAL COUNCIL</h3> The regular annual meeting of the Judicial Council of the American Medical Association will be held at Chicago, Dec. 17, 1923. The members of this Council are: Dr. M. L. Harris, Chicago, chairman; Dr. W. S. Thayer, Baltimore; Dr. J. N. Hall, Denver; Dr. I. C. Chase, Fort Worth, Texas, and Dr. F. W. Cregor, Indianapolis. <h3>ANNUAL CONFERENCE OF SECRETARIES OF CONSTITUENT STATE MEDICAL ASSOCIATIONS</h3> The secretaries of thirty-six state medical associations were present at the annual conference held at Chicago, November 16-17. Four others sent in last minute notification of inability to attend by reason of unforeseen emergencies. Except for the four states represented by these, the unrepresented associations were practically the same that have been unrepresented at previous conferences. Illinois, New Jersey and Wisconsin were also represented at the conference by the presidents of their state associations, and the president-elect of the Ohio
Infant Mortality—United States, 1992
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats:</i>Age-Adjusted Suicide Rates* for Females and Males, by Method<sup>†</sup>— National Vital Statistics System, United States, 2000 and 2014
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

From 2000 to 2014, the age-adjusted suicide rate increased from 4.0 to 5.8 per 100,000 for females and from 17.7 to 20.7 for males. Suicide rates by specific method (firearm, poisoning, suffocation, or other methods) also increased, with the greatest increase seen for suicides by suffocation. During the 15-year period, the rate of suicide by suffocation more than doubled for females from 0.7 to 1.6 and increased from 3.4 to 5.6 for males. In 2014, among females, suicide by poisoning had the highest rate (1.9), and among males, suicide by firearm had the highest rate (11.4).
Diagnosis and Surgical Correction of Congenital Coronary Artery-Coronary Sinus Fistula
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Staphylococcal susceptibility to penicillin G. The changing pattern among community strains
Authors: S. Ross
Journal: JAMA (1974)

Heretofore, penicillin has been considered adequate therapy for most soft-tissue infections due to<i>Staphylococcus aureus</i>occurring outside the hospital. One hundred thirty-three<i>S aureus</i>isolates obtained from children seen in the outpatient department and private practice were tested for resistance to penicillin G. The overall resistance to penicillin G by the Kirby-Bauer method was 84% for community strains compared to 95% for hospital strains. A survey of 309 healthy school children under 10 years of age showed that 47% harbored<i>S aureus</i>in their nares, of which approximately 68% were resistant to penicillin G. These findings suggest a trend of increasing penicillin G resistance of community (street) strains of<i>S aureus</i>similar to that already observed among hospital strains. (<i>JAMA</i>229:1075-1077, 1974)
Table of Contents
Authors: Robert Geraghty, Eric Olinger, John Sayer, Lucie Hénaut, Ziad Massy, Savannah Herbek, Daniel Edmonston, Tomokazu Souma, Peter Sohn, Yoko Narasaki, Connie Rhee, Raad Chowdhury, Manisha Jhamb, T Ikizler, P Coates, Brad Rovin, Pierre Kdigo, Jodie Babitt, Michele Eisenga, Volker Haase, Abhijit Kshirsagar, Adeera Levin, Francesco Locatelli, Jolanta Małyszko, Dorine Swinkels, Der-Cherng Tarng, Michael Cheung, Michel Jadoul, Wolfgang Winkelmayer, Tilman Drüeke, Barry Freedman, Jeffrey Kopp, Matthew Sampson, Katalin Susztak, Rui Fu, S Kim, Yutian Lei, Bettina Sehnert, Reinhard Voll, Conxita Jacobs-Cachá, Maria Soler, Maria Sanchez-Niño, Alberto Ortiz, Roman Bülow, Peter Boor, Hans-Joachim Anders, Chao Zhou, Quan He, Hua Gan, Tingting Zeng, Qiao Liu, John Moorhead, Zac Varghese, Nan Ouyang, Xiong Ruan, Szu-Yu Pan, Pei-Zhen Tsai, Yu-Hsiang Chou, Yu-Ting Chang, Fan-Chi Chang, Yen-Ling Chiu, Wen-Chih Chiang, Tien Hsu, Yung-Ming Chen, Tzong-Shinn Chu, Shuei-Liong Lin, Pragyi Shrestha, Saleh Yazdani, Romain Vivès, Rana El Masri, Wendy Dam, Bart Van De Sluis, Jacob Van Den Born, Aurélien Mary, Thibaut Objois, Michel Brazier, Youssef Bennis, Cédric Boudot, Gaëlle Lenglet, Julien Paccou, Jean-Marc Bugnicourt, Gabriel Choukroun, Tilman Drueke, Saïd Kamel, Isabelle Six, Romuald Mentaverri, Jennifer Arroyo, Diana Escobar-Zarate, Harrison Wells, Megan Constans, Ka Thao, Jessica Smith, Cynthia Sieben, Madeline Martell, Timothy Kline, Maria Irazabal, Vicente Torres, Katharina Hopp, Peter Harris
Journal: Kidney International (2021)
Follow-Up Screening of Lead-Poisoned Children near an Auto Battery Recycling Plant, Haina, Dominican Republic
Authors: Balkrishena Kaul, Randhir S. Sandhu, Conrado Depratt, Franklin Reyes
Journal: Environmental Health Perspectives (1999)

In August 1997 we performed a follow-up survey of 146 lead-poisoned children from a community near a previously active auto battery recycling smelter in Haina near Santo Domingo, Dominican Republic. Our follow-up survey confirmed a severe incidence of elevated blood lead (BPb) and erythrocyte protoporphyrin/zinc protoporphyrin (EP-ZnPP) levels. The mean BPb level was 32 micrograms/dL and the mean EP-ZnPP level was 128 micrograms/dL. The frequency distribution of BPb showed that only 9% of the children had BPb levels below the currently acceptable 10 micrograms/dL threshold level, 23% had between 10 and 19 micrograms/dL, 40% had between 20 and 39 micrograms/dL, 27% had between 40 and 99 micrograms/dL, and the remainder had > 100 micrograms/dL. These findings are significantly greater than the mean BPb and EP-ZnPP levels of 14 and 35 micrograms/dL, respectively, in a comparison group of 63 children in Barsequillo, 4 miles away. BPb frequency distributions for these groups were < 10 micrograms/dL (42%), 10-19 micrograms/dL (32%), and 20-39 micrograms/dL (16%); in the remaining 10%, BPb levels were between 40 and 99 micrograms/dL. Similarly, the corresponding frequency distribution of EP-ZnPP levels in Haina children were proportional to the severity of lead poisoning and significantly higher than those of the Barsequillo comparison group. This study reveals that at least 28% of Haina children require immediate treatment; of these, 5% with lead levels > 70 micrograms/dL are also at risk for severe neurologic sequelae, and urgent action is imperative.
Tissue Bank Expands Facilities, Efforts
Authors: Andrew A. Skolnick
Journal: JAMA (1991)

ONCE CALLED the Skin Bank of the University of Texas Medical Branch (UTMB) at Galveston, the UTMB Tissue Bank, as it is now known, collects more than just skin. For the last 2 years, it has been in the business of recycling human bone and has just begun the harvesting of human heart valves and saphenous veins (for coronary artery bypass surgery). The UTMB tissue bank, one of more than 30 nationwide that harvests skin from cadaver donors, began operating 9 years ago. By 1989, it was responsible for procuring approximately 25% of all the donor skin used to treat burn patients in the United States, says Mary G. Hodges, RN, the bank's acting technical director. In addition to procuring skin from 298 donors in 1990, the bank obtained bone from 117 donors, Hodges says. On St Valentine's Day this year, the bank harvested its first heart valve for transplantation.