tbuckley/cabot-search huggingface dataset:
IODIDE OF POTASSIUM IN BOVINE ACTINOMYCOSIS.
Journal: JAMA (1892)

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Improved Clinical Outcome after Widespread Use of Coronary-Artery Stenting in Canada
Authors: James M. Brophy
Journal: New England Journal of Medicine (2000)

To the Editor: Grines et al. (Dec.23 issue) 1 found that the benefit of coronary stenting after myocardial infarction was attributable only to the marked decrease in the rate of revascularization at six months.However, the unblinded study design may have biased decisions about revascularization in a way that could have favored the stent group.Did the independent clinical-events committee assess the appropriateness of the revascularization procedures used?Were the patients who did not undergo revascularization assessed for potential underuse of these procedures?Before worrying about the ethics of withholding stents from patients with acute infarction, the investigators should first address the possibility that their results may have been confounded by diagnostic-suspicion bias.
Correction
Authors: Hai-Xiang Sun, Yang Xu, Xin-Rong Yang, Wei-Min Wang, Haibo Bai, Ruo-Yu Shi, Suresh Nayar, Ranjan Devbhandari, Yi-Zhou He, Qin-Feng Zhu, Yun-Fan Sun, Bo Hu, Mehtab Khan, Robert Anders, Jia Fan, Yi-Wen Huang, Sien-Sing Yang, Szu-Chieh Fu, Ting-Chuan Wang, Cheng-Kai Hsu, Ding-Shinn Chen, Jui-Ting Hu, Jia-Horng Kao
Journal: Hepatology (2018)
Diagnosis and treatment of depression in a 102-year-old woman
Authors: S. L. Kushnir
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Under the influence or if you drink don't meet
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Banning Tobacco Advertising: Boon to the Industry?-Reply
Authors: Allan M. Brandt
Journal: JAMA (1993)

<h3>In Reply.</h3> —Smoking is a highly complex and insufficiently understood behavior. Consequently, effective reductions in smoking behavior are likely to be achieved through a comprehensive public health strategy based on the best available data. At the same time, antismoking policies must be respectful of human rights and avoid promoting intolerance of socially unacceptable behaviors. Dr Simonich is correct to warn that a ban on advertising could sharply reduce the cost of doing business for cigarette manufacturers. Since the cigarette market exhibits some price elasticity, significant increases in taxes may be necessary to maintain or increase the price of cigarettes. We support a multidimensional public health approach to cigarette smoking, including tax increases, health education, smoking prevention, and cessation programs. We urge some caution regarding the remaining two suggestions made by Simonich—government-imposed smoking restrictions and a ban on the introduction of new brands of cigarettes. Government-imposed smoking restrictions can represent a
Azathioprine and varicella
Authors: R. N. Fine
Journal: JAMA (1969)

Clinical and serologic evidence of varicella developed in an 8-year-old boy while he was receiving azathioprine and steroids for immunosuppression 16 months after renal homotransplantation. The clinical course was benign, and no adverse effects on renal function were observed in relation to the clinical varicella.
Characteristic Roentgen Findings of Colon in Exudative Enteropathy Secondary to Hirschsprung's Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperthermia and Dehydration-Related Deaths Associated With Intentional Rapid Weight Loss in Three Collegiate Wrestlers—North Carolina, Wisconsin, and Michigan, November-December 1997
Journal: JAMA (1998)

During November 7-December 9, 1997, three previously healthy collegiate wrestlers in different states died while each was engaged in a program of rapid weight loss to qualify for competition. In the hours preceding the official weigh-in, all three wrestlers engaged in a similar rapid weight-loss regimen that promoted dehydration through perspiration and resulted in hyperthermia. The wrestlers restricted food and fluid intake and attempted to maximize sweat losses by wearing vapor-impermeable suits under cotton warm-up suits and exercising vigorously in hot environments. This report summarizes the investigation of these three cases.
Disturbances of Conjugate Horizontal Eye Movements in the Monkey
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Just Words
Authors: Alexander Gode
Journal: JAMA (1964)

The doodles born as side effects of telephone conversations can be beautiful, but I always hesitate to call them art, even in the most modern (abstract-abstraught-distraught) sense of the term. I used to think that the critical justification of the harsh verdict implied in that hesitation is that a doodle cannot be planned and is never the execution of a preexisting total conception, but I have been told that novels quite often are not planned either, and of course I do not want to be forced to admit that I feel most novels to be no more than verbal doodles. However that be, I shall continue to insist that a learned paper which just grows instead of being the execution of a pre-existing total conception is no good, even at the risk of having to admit that I consider a superior learned paper a work of art. The distinction between
International Meeting of Reticuloendothelial Society
Journal: JNCI Journal of the National Cancer Institute (1970)

Journal Article International Meeting of Reticuloendothelial Society Get access JNCI: Journal of the National Cancer Institute, Volume 44, Issue 6, June 1970, Page 1391, https://doi.org/10.1093/jnci/44.6.1391-a Published: 01 June 1970
Manuscripts Approved for JNCI During April–May 1976
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Manuscripts Approved for JNCI During April–May 1976 Get access JNCI: Journal of the National Cancer Institute, Volume 56, Issue 6, June 1976, Page 1285, https://doi.org/10.1093/jnci/56.6.1285-b Published: 01 June 1976
CME Hiatus: July Through December 2002
Authors: Mark Marinella
Journal: JAMA (2002)

Cellulitis and Sepsis Due to SphingobacteriumTo the Editor: Cellulitis-associated sepsis is usually due to grampositive organisms such as group A streptococci or Staphylococcus aureus.This report describes the case of an elderly man with cellulitis and sepsis due to Sphingobacterium spiritivorum the patient most likely acquired from walking barefoot in his back yard.Report of a Case.A 72-year-old man with Parkinson disease presented with acute onset of fever, chills, leg redness, and confusion.Vital signs were: temperature, 38.8°C; pulse, 90/ min; respirations, 40/min; and blood pressure, 95/57 mm Hg.Physical examination revealed marked erythema and warmth of the entire right leg without crepitus, discharge, or bullae.There was evidence of chronic venous stasis, onychomycosis, and intertriginous cracking of the toes.The white blood cell count was 26100 cells/mm 3 with 66% neutrophils and 33% band forms.Computed tomography of the leg revealed evidence of cellulitis without abscess, myositis, or fasciitis.The patient was recusitated with saline and received 1.5 g of cefazolin every 8 hours and 3 g ampicillin-sulbactam every 6 hours after blood cultures were obtained.Over the next 48 hours, the patient's mental status, vital signs, and leukocyte count returned to normal levels.By the third day, the leg erythema had almost resolved.Two sets of blood cultures yielded S spiritivorum, which was resistant to amikacin, gentamicin, tobramycin, and aztreonam; the organism was susceptible to ceftriaxone, imipenem, piperacillin, trimethoprim-sulfamethoxazole, and ciprofloxacin.Further questioning revealed that the patient commonly walked barefoot in his back yard, often in the garden area, which had been moist due to recent heavy rainfall.At discharge, the patient was prescribed 500 mg of oral ciprofloxacin twice daily for 10 days and advised to always wear shoes when going outside.Comment. S spiritivorum, a former member of the Flavobacterium genus, 1 has not been reported, to my knowledge, as a cause of community-acquired sepsis in an immunocompetent person.Previously reported cases of infection due to Sphingobacterium species have been nosocomially acquired or have involved immunocompromised hosts (eg, those having human immunodeficiency virus infection or receiving hemodialysis). 1-4Community-acquired soft-tissue infection due to this organism may be overlooked, and hence underestimated, if blood and tissue or wound cultures are not performed in patients with cellulitis.Sphingobacteria are ubiquitous gram-negative organisms containing large amounts of sphingophospholipids and are naturally present in soil, plant material, and water. 1,2,5This patient had dry, cracked skin with evidence of tinea pedis and onychomycosis, which likely served as portals of entry for the bacteria as he walked barefoot in his yard and garden.The use of footwear when walking outdoors, especially if there is any breach in skin integrity of the feet, may help to prevent cellulitis and resulting sepsis.
Insulin four times daily is better than twice daily for diabetes in pregnancy
Journal: BMJ (1999)

Insulin four times daily is better than twice daily for diabetes in pregnancyDiabetes mellitus complicates about 5% of all pregnan› cies.Good glycaemic control reduces maternal and perinatal morbidity, but there are no data on whether intensifying insulin treatment beyond the conventional twice daily regimen is of benefit.In a randomised con› trolled open label study in nearly 400 diabetic pregnant patients Nachum et al found that a four times daily regimen improved both perinatal outcome and maternal glycaemic control compared with the conventional twice daily regimen (p 1223).The rate of severe maternal hypoglycaemia was, however, similar in both groups.
An open-label international multicentric phase II study of nilotinib in progressive pigmented villo-nodular synovitis (PVNS) not amenable to a conservative surgical treatment.
Authors: Isabelle Ray-Coquard, Hans Gelderblom, Christine Chevreau, Judith R. Kroep, Antoine Italiano, Silvia Stacchiotti, Axel Le Cesne, Sophie Piperno-Neumann, Virginia Ferraresi, Florence Duffaud, Nicolas Penel, Philippe A Cassier, Martin Tatersall, Andrew Bassim Hassan, Binh Bui Nguyen, Veronique Bourne Branchu, Severine Guillemaut, Claire Cropet, David Perol, Jean-Yves Blay
Journal: Journal of Clinical Oncology (2012)

10006 Background: PVNS, also known as tenosynovial giant cell tumor (TGCT), is a rare pathological entity affecting the synovium in young adults. This neoplastic disease is driven by a t(1;2) translocation which results in the fusion of COL6A3 and M-CSF genes. Nilotinib has inhibitory properties on M-CSF receptor pathway which could be of therapeutic interest in pts with non resectable PVNS. Methods: In this open-label International, multicenter, non-randomized, phase II study the primary objective is to evaluate the efficacy of nilotinib treatment in patients (pts) with progressive or relapsing PVNS not amenable to surgery or in whom surgery would be mutilating, as measured by the 12-week progression-free rate (12-w PFR) validated by an independent committee. Using a Bayesian design with a stopping rule for futility, interim analyses were planned after the inclusion of 10 pts and then every 5 pts. Results: From December 2010 to November 2011, 33 pts with progressive disease from 17 institutions from Europe and Australia were enrolled. 14 pts (median age 37 y (range: 19-68), 7 males) were analyzed in the 2 nd interim analysis. Median time since diagnosis was 4.4 years (range: 0.2-26). Primary tumour was located on a knee for 10 pts (71%) and on hip (1 pt, 7%), finger (7%), foot (7%), hand (7%), respectively. 69% of pts had a inoperable PVNS and 31% had a resectable tumour but requiring mutilating surgery. All pts started nilotinib at the planned dose of 800 mg/day. At a median follow-up of 8.9 months (range: 0.6-11), 2 pts had a dose reduction and 1 pt had discontinued nilotinib after 14 days due to toxicity. Nilotinib was well tolerated, with only 2 pts experiencing grade 3 adverse events (anorexia: 1 pt; hepatic failure: 1 pt).The 12-w PFR was 85.7% (95%CI, 57.2%-98.2%), in favour of the study continuation. No OR was observed at w-12; 1 pt (7%) was in PR at w-30. Updated results will be presented after the 3 rd interim analysis. Conclusions: Nilotinib treatment induces disease stabilisation in a large proportion of PVNS patients with non resectable disease or in whom resection would be mutilating.
Regulation of Muscle Mass by Follistatin and Activins
Authors: Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, Elisabeth R. Barton
Journal: Endocrine Reviews (2010)

Myostatin is a TGF-β family member that normally acts to limit skeletal muscle mass. Follistatin is a myostatin-binding protein that can inhibit myostatin activity in vitro and promote muscle growth in vivo. Mice homozygous for a mutation in the Fst gene have been shown to die immediately after birth but have a reduced amount of muscle tissue, consistent with a role for follistatin in regulating myogenesis. Here, we show that Fst mutant mice exhibit haploinsufficiency, with muscles of Fst heterozygotes having significantly reduced size, a shift toward more oxidative fiber types, an impairment of muscle remodeling in response to cardiotoxin-induced injury, and a reduction in tetanic force production yet a maintenance of specific force. We show that the effect of heterozygous loss of Fst is at least partially retained in a Mstn-null background, implying that follistatin normally acts to inhibit other TGF-β family members in addition to myostatin to regulate muscle size. Finally, we present genetic evidence suggesting that activin A may be one of the ligands that is regulated by follistatin and that functions with myostatin to limit muscle mass. These findings potentially have important implications with respect to the development of therapeutics targeting this signaling pathway to preserve muscle mass and prevent muscle atrophy in a variety of inherited and acquired forms of muscle degeneration.
Financial Support of Medical Schools
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cough, dyspnoea and purulent sputum in a 66-yr-old nonsmoking female
Authors: D. Jager, K-M. Muller, A. Gillissen, G. Schultze-Werninghaus
Journal: European Respiratory Journal (1999)

Case historyA 66-yr-old female presented with dyspnoea on exercise, severe cough, purulent sputum and intermittent chest pain under both costal arches for the last 14 days.Five months prior to admission, pulmonary tuberculosis of both lower lobes had been diagnosed microscopically as the cause of recurrent bilateral pleural and pericardial effusions and pericardial thickening, and the patient was still under a two-drug antituberculous regimen.Loss of weight and fever were denied.She was a nonsmoker.Physical examination revealed wheeze over the left lower chest.The chest radiograph on admission was normal except for pleural thickening at the left lower chest wall associated with a small pleural effusion.Pulmonary function tests showed the following results: total lung capacity (TLC) 4.5 L (70% pred), forced expiratory volume in one second (FEV1) 1.3 L (45% pred), forced vital capacity (FVC) 2.2 L (59% pred), peak expiratory flow (PEF) 51%, maximal expiratory flow when 75% of the FVC remains to be exhaled (MEF75%) 36% pred; FEV1/FVC 83% pred, airway resistance (Raw) 0.55 kPa .L -1 .s and a slight hypoxaemia (9.1 kPa).Because a swab of the throat when cultured grew Escherichia coli, Pseudomonas fluorescens and Staphylococcus epidermidis, oral antibiotics were added to a routine antiobstructive therapy.There was some improvement in the symptoms, but residual cough and dyspnoea persisted.Owing to the development of haemoptysis, fibreoptic bronchoscopy was performed, which showed a tumour almost occluding the entrance of the lingula bronchus (fig.1).The biopsy of the tumour area is shown in figure 2. Subsequently, the chest radiograph as well as a computed tomographic (CT) scan changed from almost normal to the states shown in figures 3 and 4.After a second bronchoscopy to gain a definitive histology the patient experienced severe paroxysms of coughing.