Doxorubicin Cardiomyopathy
Authors: SHYAMAL K. SANYAL
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 July 1978Doxorubicin CardiomyopathySHYAMAL K. SANYAL, F.A.A.P., F.A.C.C., WARREN W. JOHNSON, M.D.SHYAMAL K. SANYAL, F.A.A.P., F.A.C.C.Search for more papers by this author, WARREN W. JOHNSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-1-136 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Bristow and colleagues (Ann Intern Med 88:168-175, 1978) advocating the routine use of right endomyocardial biopsy in patients receiving doxorubicin raises several questions.In their study a scoring system based on the ultrastructural characteristics of myocytes was used to quantitate the severity of drug-induced damage to the heart. Myofibrillar loss, a major criterion of their scoring system, can involve either thick or thin myofilaments, or both (1). Buja and associates (2) have shown that doxorubicin-induced myofibrillar loss mainly involves thick filaments. Bristow and co-authors, however, do not give a precise definition of this...References References1. SANYALJOHNSONTHAPARPITNER SWMS: An ultrastructural basis for electrocardiographic alterations associated with Duchenne's progressive muscular dystrophy. Circulation, 57:1122-1129, 1978 CrossrefMedlineGoogle Scholar2. BUJAFERRANS LV: Myocardial injury produced by antineoplastic drugs. Recent Adv Stud Cardiac Struct Metab 6:487-497, 1975 MedlineGoogle Scholar3. MARONFERRANSROBERTS BVW: Ultrastructural features of degenerated cardiac muscle cells in patients with cardiac hypertrophy. Am J Pathol 79:387-434, 1975 MedlineGoogle Scholar4. JAENKEFAJARDO RL: Adriamycin-induced myocardial lesions. Am J Surg Pathol 1:55, 1977 CrossrefMedlineGoogle Scholar5. RAMOSMEYERKORFHAGENWONGKAPLAN ARJKS: Echocardiographic evaluation of adriamycin cardiotoxicity in children. Cancer Treat Rep 60:1281-1284, 1976 MedlineGoogle Scholar1. BUJAFERRANS LV: Myocardial injury produced by antineoplastic drugs. Recent Adv Stud Cardiac Struct Metab 6:487-497, 1975 MedlineGoogle Scholar2. BUJAFERRANSMAYERROBERTSHENDERSON LVRWE: Cardiac ultrastructural changes induced by daunorubicin therapy. Cancer 32:771-787, 1973 CrossrefMedlineGoogle Scholar3. JAENKE R: An anthracycline antibiotic-induced cardiomyopathy in rabbits. Lab Invest 30:292-304, 1974 MedlineGoogle Scholar4. MASONBRISTOWBILLINGHAMDANIELS JMMJ: Invasive and noninvasive methods of assessing adriamycin cardiotoxicity in man: superiority of histopathologic assessment using endomyocardial biopsy. Cancer Treat Rep, in press Google Scholar1. RINEHARTLEWISBALCERZAK JRS: Adriamycin cardiotoxicity in man. Ann Intern Med 81:475-478, 1974 LinkGoogle Scholar2. BRISTOWMASONBILLINGHAMDANIELS MJMJ: Endomyocardial biopsy and systolic time intervals in detection of adriamycin cardiotoxicity (abstract). Circulation 54(suppl 2):II-80, 1976 Google Scholar3. EWYJONESGROVESDURIEWRIGHT GSBBI: Echocardiographic diagnosis of adriamycin heart disease (abstract). Proc West Sect Oncol, 1975 Google Scholar4. JONESEWYGROVES SGB: Echocardiographic detection of adriamycin heart disease (abstract). Proc Am Soc Clin Oncol, 1975 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Jude Children's Research Hospital Memphis, TN 38101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDoxorubicin cardiotoxicityCytostatic and immunosuppressive drugs 1 July 1978Volume 89, Issue 1Page: 136-137KeywordsBiopsyCardiomyopathiesDrugsHeartLongitudinal studiesPatient advocacy Issue Published: 1 July 1978 PDF downloadLoading ...