tbuckley/cabot-search huggingface dataset:
Abstract 227: BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy
Authors: Chia-Yu Hsu, Yun-Yu Chen, Chen-Fu Lo, Tai-Yu Chiu, Ching-Ping Chen, Chen-Lung Huang, Chung-Yu Huang, Min-Hsien Wang, Yu-Sheng Chao, Joe C. Shih, Teng-Kuang Yeh, Lun K. Tsou, Chiung-Tong Chen
Journal: Cancer Research (2019)

Abstract Zinc(II)-dipicolylamine (Zn-DPA) have been described to specifically complex with phosphatidylserine (PS), which has a higher level at the external surface of cancer cells in tumorigenic condition. BPRDP056 is a Zn-DPA-SN38 conjugate designed to provide a PS-targeting drug delivery of cytotoxic payload SN-38 at the tumor microenvironment, thereby, decrease the dosage of SN38, while induce apoptosis in cancer cells. The in vivo therapeutic efficacy of BPRDP056 against the growths of human tumors has been shown significant in mice subcutaneously bearing a tumor type of pancreas, prostate, colon, liver, breast and glioblastoma, as well as in mice with an orthotopic pancreatic tumor. BPRDP056 shrunk tumors at a lower dosing intensity (~20%) of SN38 compared to CPT-11 in all models tested. Micro-Western assays showed that BPRDP056 exhibited apoptotic cell death signal levels similar to those of CPT-11 in the treated tumors in mice. Furthermore, pharmacokinetic and preliminary toxicology studies showed that BPRDP056 has a good stability in circulation with an acceptable therapeutic safety window in mice. BPRDP056 has been demonstrated with a tumor targeting ability and thus increases the cytotoxic payload SN38 concentration in situ for improved efficacy. Its therapeutic spectrum against malignant neoplasm will be expected to cover the PS-rich tumor microenvironment of all cancer types. BPRDP056 is a first-in-class Small Molecule Drug Conjugate for anti-cancer therapy. Citation Format: Chia-Yu Hsu, Yun-Yu Chen, Chen-Fu Lo, Tai-Yu Chiu, Ching-Ping Chen, Chen-Lung Huang, Chung-Yu Huang, Min-Hsien Wang, Yu-Sheng Chao, Joe C. Shih, Teng-Kuang Yeh, Lun K. Tsou, Chiung-Tong Chen. BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 227.
ALG-000184, a prodrug of capsid assembly modulator ALG-001075, demonstrates best-in-class preclinical characteristics for the treatment of chronic hepatitis B
Authors: Qingling Zhang, Sandrine Vendeville, Vladimir Serebryany, Michael Welch, Jyanwei Liu, Caroline Williams, Yannick Debing, Andreas Jekle, Sarah Stevens, Jerome Deval, Tse-I Lin, Dinah Misner, Sushmita Chanda, Raymond F Schinazi, Pierre Raboisson, Julian Symons, Lawrence Blatt, Leonid Beigelman, David Smith
Journal: Journal of Hepatology (2020)
Sobre etiología de la tuberculosis y del artritismo.
Journal: JAMA (1928)

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De Quervain's disease
Authors: G. W. Wharton
Journal: JAMA (1968)

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Addition to Author Affiliations
Journal: JAMA Pediatrics (2016)

Lan Guo, MD; Yan Xu, MS; Jianxiong Deng, PhD; Jinghui Huang, MS; Guoliang Huang, MS; Xue Gao, MD; Hong Wu, MS; Siyuan Pan, MD; Wei-Hong Zhang, MD, PhD; Ciyong Lu, MD, PhD
Book Review Common Infections of the Female Urethra and Cervi . By Frank Kidd, M.A., M.Ch. (Cantab.), F.R.C.S. (England) and A. Malcolm Simpson, B.A., M.B., D.P.H. (Cantab.) with additional chapters by George T. Western, M.D. and M. S. Mayou, F.R.C.S. Published by Humphrey Milford, Oxford University Press. 197 pages. Second Edition.
Journal: New England Journal of Medicine (1930)
Some things medical ethics is not
Authors: K. D. Clouser
Journal: JAMA (1973)

Medical ethics has frequently been identified or coupled with other areas of study: history of medicine, family and community medicine, religion, counseling, and psychiatry. Such identifications are incorrect and are due to certain misconceptions. Aside from guiding those contemplating programs in medical ethics and alerting those already involved, the purpose of this article is to clear the ground for a positive definition and description of medical ethics.
A SIMPLE CLAMP FOR MAKING BALKAN FRAMES OF IRON PIPE
Journal: JAMA (1920)

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THE CLASSIFICATION OF CARDIAC DIAGNOSIS
Journal: JAMA (1921)

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Incorrect Reporting
Journal: JAMA (2015)

Sayeed Ikramuddin, MD; Robin P. Blackstone, MD; Anthony Brancatisano, MD, PhD; James Toouli, MD, PhD; Sajani N. Shah, MD; Bruce M. Wolfe, MD; Ken Fujioka, MD; James W. Maher, MD; James Swain, MD; Florencia G. Que, MD; John M. Morton, MD; Daniel B. Leslie, MD; Roy Brancatisano, MD; Lilian Kow, MD, PhD; Robert W. O’Rourke, MD; Clifford Deveney, MD; Mark Takata, MD; Christopher J. Miller, MS; Mark B. Knudson, PhD; Katherine S. Tweden, PhD; Scott A. Shikora, MD; Michael G. Sarr, MD; Charles J. Billington, MD
Drug administration can be improved by simple guidelines discussed by all staff affected
Journal: BMJ (2000)

Vaccines may have non-specific effects in developing countriesAlthough studies have found that vaccination against measles may have a non-specific beneficial effect in developing countries, the effect of other routine immunisations has not been assessed.On p 1435 Kristensen et al examined the mortality in vaccinated and unvaccinated children in rural Guinea-Bissau.Both BCG and measles vaccines were associated with reductions in mortality that could not be explained by the prevention of measles or tuberculosis.Polio and diphtheria, tetanus, and pertussis vaccines were associated with higher mortality.Since different vaccines were associated with opposite tendencies, selection biases are unlikely to explain these associations fully.The authors conclude that non-specific effects may occur with many routine vaccinations in areas with high mortality and should be considered when planning immunisation programmes.
Fluorescent spectrophotometric analysis in the evaluation of porphyria
Authors: D. S. Walsh
Journal: JAMA (1994)

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Erratum for Euro Surveill. 2016;21(50)
Journal: Eurosurveillance (2017)

© This work is licensed under a Creative Commons Attribution 4.0 International License. Closure This is a corrected article applying to the following content: Serodiagnosis of Zika virus (ZIKV) infections by a novel NS1-based ELISA devoid of cross-reactivity with dengue virus antibodies: a multicohort study of assay performance, 2015 to 2016
BALTIMORE &amp;amp; OHIO R. R.
Journal: JAMA (1884)

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Long-term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle-aged men
Authors: T. E. Strandberg
Journal: JAMA (1991)

<h3>Objective.</h3> —To investigate the long-term effects of multifactorial primary prevention of cardiovascular diseases (CVD). <h3>Design.</h3> —The 5-year randomized, controlled trial was performed between 1974 and 1980. The subjects and their risk factors were reevaluated in 1985. Posttrial mortality follow-up was continued up to December 31, 1989. <h3>Setting.</h3> —Institute of Occupational Health, Helsinki, Finland, and Second Department of Medicine, University of Helsinki. <h3>Participants.</h3> —In all, 3490 business executives born during 1919 through 1934 participated in health checkups in the late 1960s. In 1974, 1222 of these men who were clinically healthy, but with CVD risk factors, were entered into the primary prevention trial; 612 were randomized to an intervention and 610 to a control group. <h3>Interventions.</h3> —During the 5-year trial, the subjects of the intervention group visited the investigators every fourth month. They were treated with intensive dietetic-hygienic measures and frequently with hypolipidemic (mainly clofibrate and/or probucol) and antihypertensive (mainly β-blockers and/or diuretics) drugs. The control group was not treated by the investigators. <h3>Main Outcome Measures.</h3> —Total mortality, cardiac mortality, mortality due to other causes. <h3>Results.</h3> —Total coronary heart disease risk was reduced by 46% in the intervention group as compared with the control group at end-trial. During 5 posttrial years, the risk factor and medication differences were largely leveled off between the groups. Between 1974 and 1989 the total number of deaths was 67 in the intervention group and 46 in the control group (relative risk [RR], 1.45; 95% confidence interval [Cl], 1.01 to 2.08;<i>P</i>=.048); there were 34 and 14 cardiac deaths (RR, 2.42; 95% Cl, 1.31 to 4.46; P=.001), two and four deaths due to other CVD (not significant), 13 and 21 deaths due to cancer (RR, 0.62; 95% Cl, 0.31 to 1.22;<i>P</i>=.15), and 13 and one deaths due to violence (RR, 13.0; 95% Cl, 1.70 to 98.7;<i>P</i>=.002), respectively. Multiple logistic regression analysis of treatments in the intervention group did not explain the 15-year excess cardiac mortality. <h3>Conclusion.</h3> —These unexpected results may not question multifactorial prevention as such but do support the need for research on the selection and interaction(s) of methods used in the primary prevention of cardiovascular diseases. (<i>JAMA</i>. 1991;266:1225-1229)
Risks and Unexpected Reactions in Disulfiram Therapy of Alcoholism
Journal: JAMA (1963)

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Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency
Authors: D Fan
Journal: Cardiovascular Research (1995)

Objective: Oxygen consumption (MVO,) of stunned myocardium is relatively high compared to, and poorly correlated with, systolic contractile function.The aim of this study was to investigate whether an increased afterload dependency, induced by the decreased contractility of the stunned myocardium, contributes to the large variability in the mechanical efficiency data.Methods: In 13 anaesthetised open thorax pigs undergoing two cycles of 10 min occlusion of left anterior descending coronary artery and 30 min reperfusion, segment shortening, the slope of end systolic pressure segment length relationship (E,,), external work (EW, derived from the area inside the left ventricular pressure segment length loop), the efficiency of energy conversion (EET, =EW/PLA X lOO%, where PLA = total pressure-segment length area), mechanical efficiency (EW/MVO& and their dependency on left ventricular end systolic pressure (P,,) were determined before and after induction of stunning, and during subsequent inotropic stimulation with dobutamine (1 and 3 pg.kg-'.min-'over 15 min).Results: The stunning protocol not only caused significant decreases in segment shortening, external work, energy conversion efficiency, and EWA4V02 but also increased the afterload dependency of these variables.Before stunning an increase in P,, from 100 to 160 mm Hg decreased segment shortening from 18(SEM I)% to 14(2)% (P > 0.05) and increased external work from 206( 18) to 254(32) mm Hg.mm (P < 0.05).After induction of stunning the same increase in P,, caused a decrease in segment shortening from 9.5( 1.8)% to -4.6(2.1)%(P<O.O5) and in external work from 149(21) to -1 l(l0) mm Hg.mm (P<O.O5).The afterload dependency of the PLA was not altered by stunning, but the afterload dependency of energy conversion efficiency increased, since efficiency decreased from 67(3)% to 59(5)% as P,, was increased from 100 to 160 mm Hg before stunning, but from 57(5) to -7(5)% after,induction of stunning (P < 0.05).Furthermore, the same increase in P,, resulted in an 8% decrease of EW/MV02 before stunning and 107% after induction of stunning.Infusion of dobutamine not only restored segment shortening, external work, energy conversion efficiency, and EW/MVO> of the stunned myocardium, but also attenuated their afterload dependency to prestunning levels.Conclusions: Myocardial stunning increases the afterload dependency of segment shortening, external work, energy conversion efficiency, and mechanical efficiency, which can be attenuated by inotropic stimulation with dobutamine.However, the decrease in left ventricular end systolic pressure, which accompanies the induction of stunning.counteracts the decrease in these variables.These two mechanisms can explain most of the reported scatter il'mechanical efficiency.
Drug evaluation programs of the AMA 1905-1966
Authors: J. Bishop
Journal: JAMA (1966)

Sixty-one years ago, the Council on Pharmacy and Chemistry was created as a standing committee of the Board of Trustees of the American Medical Association. Its declared purpose to serve the medical profession by providing accurate information on the status of agents used in the treatment of disease has remained constant. In its early years, the efforts of the Council were directed to the suppression of advertisements for quack medicines and nostrums, the analysis of secret remedies, and the publication of their formulae. The principle of absolute impartiality to all manufacturers and all products was enunciated and rigidly adhered to. Certain rules and standards concerning the origin, composition, and availability of tests for the identification of proprietary drugs were established with the object of protecting the medical profession and the public against fraud, undesirable secrecy, and objectionable advertising. To aid the Council, the AMA established a chemical laboratory to determine
Biographical Sketches AND Letters of T. Mitchell Prudden, M.D.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary emphysema and liver disease. Occurrence in an alpha-antitrypsin-deficient adult
Authors: C. J. Donlan
Journal: JAMA (1975)

An elderly woman manifested both pulmonary and hepatic disease secondary to α<sub>1</sub>-antitrypsin deficiency. The liver biopsy specimen showed the characteristic findings of this condition, most importantly, the presence of PAS-positive, diastase-resistant intracytoplasmic inclusions. (<i>JAMA</i>232:1147-1149, 1975)