tbuckley/cabot-search huggingface dataset:
From the National Institutes of Health
Authors: William F. Raub
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exploring and expanding the research agenda for diabetes in managed care. A report of a Centers for Disease Control and Prevention-Managed Care Workshop.
Journal: Diabetes Care (1999)

The objective of this article is to describe the proceedings of a workshop organized by the Centers for Disease Control and Prevention (CDC) to 1) summarize current preventive care practices for people with diabetes in managed care organizations (MCOs) in the U.S., 2) understand the strengths and barriers to diabetes-related health services research in MCOs, and 3) highlight the major research questions and approaches to improve diabetes-related research in these organizations. Review and synthesis of presentations and discussions are provided. MCOs have considerable potential to enhance diabetes health services research because of their access to large diverse populations, novel health service interventions, and availability of data systems that link patients, health care providers, health care use, and health outcomes. Barriers to improved MCO-based research include confounding by concurrent interventions and secular trends, lack of control groups for rigorous evaluation of interventions, and the heterogeneous structures of MCOs. Future research, particularly if conducted in a collaborative environment, has the potential to improve the understanding of trends in health services, improve the understanding of characteristics of MCOs, and evaluate complex interventions directed at patients, health care providers, and systems of care.
A Surgeon in Arms.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Monatsschrift für Kinderheilkunde, Berlin
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME LESSONS FROM TRENCH JAUNDICE
Journal: JAMA (1918)

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Front &amp; Back Matter
Authors: Andrew Shepherd, Mutsuhiro Nakao, Takeaki Takeuchi, Gregory Fricchione, Giovanni Castellini, Luca Montanelli, Carlo Faravelli, Valdo Ricca, Ferrán Catalá-López, Lisa Cosgrove, Sheldon Krimsky, Emily E. Wheeler, Jenesse Kaitz, Scott B. Greenspan, Nicole L. DiPentima, Thomas N. Hyphantis, Michael Berk, Andre F. Carvalho, Roger S. McIntyre, Paolo Leombruni, Giuseppe Rocca, Secondo Fassino, Filippo Gastaldi, Barbara Nicotra, Sara Siccardi, Luca Lavagnino, Lorna Farquharson, Andrew K. MacLeod, Thomas N. Wise, Marta Suárez-Pinilla, Paula Suárez-Pinilla, Jose María Valderas, Manuel Gómez-Beneyto, Salvador Martinez, Vicent Balanzá-Martínez, Joan Climent, Alfonso Valencia, John McGrath, Benedicto Crespo-Facorro, Jose Sanchez-Moreno, Eduard Vieta, Rafael Tabarés-Seisdedos, Satz Mengensatzproduktion, Druckerei Stückle, Druckerei Stückle
Journal: Psychotherapy and Psychosomatics (2014)
Leads from the MMWR. Lack of transmission of human immunodeficiency virus through Rho(D) immune globulin (human)
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chloroform Accidents.
Authors: J. C. Reeve
Journal: JAMA (1889)

<h3>To the Editor:</h3> —I take the liberty of writing you in regard to the article on "Chloroform Accidents" inThe Journalof October 19th. I have been for many years following the practice there described for prevention of death under anæsthetics, and have over and over again presented it to the profession of this country. First in the<i>American Journal of Medical Sciences</i>, April, 1876, on "The Influence of the Injection of Narcotics upon the Anæsthetic Process;" again in "Transactions of the State Medical Society of Ohio," 1879, in which paper I particularly urged the influence of atropia in sustaining the heart's action; further, in American edition "Holmes' Surgery," and several times in journals. Now, I do not wish to trouble you, and care little about the<i>personal</i>honor of priority in this matter, but think that when a procedure is published as a<i>good thing</i>, being so discovered<i>abroad</i>
Docetaxel-carboplatin chemotherapy combined with cetuximab in patients with locally advanced or metastasized non-small cell lung cancer (NSCLC): results of the nonrandomized phase II study TaxErb.
Authors: J. R. Fischer, F. Griesinger, T. Fink, E. Buchholz, T. Salm, A. Marseille, M. Wolf
Journal: Journal of Clinical Oncology (2010)

7546 Background: Combination chemotherapy with carboplatin-docetaxel is effective and safe for patients with locally advanced or metastasized NSCLC. We hypothesized that adding the monoclonal anti-EGRF antibody cetuximab to this regimen will improve response rate and survival without a substantial increase in toxicity. Methods: Open, noncontrolled phase II study in pts with locally advanced or metastasized NSCLC, ECOG performance status ≤ 2 and no prior systemic chemotherapy were treated with carboplatin AUC5 (d 1) q4w for 4-6 cycles and docetaxel 35 mg/m2 (d1, 8, 15) q4w; cetuximab 400/250 mg/m2 (d 1) q1w until progression or intolerable toxicity (max. 12 month). The primary endpoint was response rate defined as complete or partial remission according to RECIST. Secondary endpoints were toxicity, 1 year survival, median overall and progression-free survival. Results: Of 74 patients recruited (safety population), 6 were stage IIIb and 68 stage IV (UICC 6). ECOG 0/1/2 was 33.8%/55.4%/4.1% (5 pts no data). 29.7% had prior surgery and 14.9% prior radiotherapy. Pts received a mean of 3.5 ± 1.7 cycles docetaxel-carboplatin-cetuximab. 219 adverse events were grade 1-2 and 47 grade 3-4. Skin toxicity (71.6% of all pts; 81.1% of which G1/2, 18.9% G3/4), dyspnoea (33.8%; 84.0% of which G1/2; 16.0% G3-4) and anaemia (31.1%; 95.7% of which G1/2, 4.4% G3) were most frequent. 8 pts, discontinued therapy, 1 pt received a reduced dose.59 patients were available for the ITT efficacy analysis: 29 pts had partial response (response rate 49.2%; 95%CI 36.4-61.9%), 21 stable and 9 progressive disease. 1 year progression-free survival was 13.8% and overall survival 72.8%. Median overall survival was 12.92 and progression free survival 4.98 (95%CI 4.20-6.03) months. Conclusions: Cetuximab is a valuable addition to carboplatin-docetaxel combination chemotherapy with a response rate of 49% and an acceptable toxicity. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Merck Pharma GmbH, Sanofi-Aventis Deutschland GmbH Marck Pharma GmbH, Merck Pharma GmbH, sanofi-aventis Merck Pharma GmbH, sanofi-aventis
Peak bone mineral density in young women
Authors: R. R. Recker
Journal: JAMA (1993)

<h3>In Reply.</h3> —The comments by Drs Recker and Heaney call to attention our incomplete understanding of the dynamics and probable variation in the peak bone mass concept. From the three recent cross-sectional studies<sup>1-3</sup>of bone density among a total of 197 young women, aged 9 to 21 years, peak lumbar spine and peak femoral neck bone density were observed for between 15 and 18 years. From the two large cross-sectional studies<sup>4,5</sup>using a total of 694 women, aged 20 to 40 years, no peak was observed for lumbar spine or femoral neck bone density after age 20 years. From their longitudinal study of 98 young women aged 9 to 19 years, Theintz and coworkers<sup>6</sup>observed cessation of lumbar spine and femoral neck bone gain by age 18 years. In contrast, Recker and Heaney reported that cessation of total body and spinal bone mineral gain occurred at about age
Humoral and Cell-Mediated Immune Status in Mice Exposed to Chloral Hydrate
Authors: Bernadine M. Kauffmann, Kimber L. White, Virginia M. Sanders, Kathryn A. Douglas, Larry E. Sain, Joseph F. Borzelleca, Albert E. Munson
Journal: Environmental Health Perspectives (1982)

Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evaluate the functional status of the immune system in random-bred CD-1 mice exposed to chloral hydrate for 14 and 90 days. Male mice, following 14 or 90 days of exposure to 1/10 and 1/100 the actual oral LD50, exhibited no alterations in either humoral or cell-mediated immunity. However, female mice exposed for 90 days to chloral hydrate in the drinking water demonstrated a significant depression in humoral immune function. This depression was observed when spleen cells from exposed mice were evaluated for their ability to produce antibody against sheep erythrocytes. These females did not demonstrate any changes in cell-mediated immune status.
CENSORSHIP WANTED.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paneless stress
Authors: S. Vaisrub
Journal: JAMA (1979)

Like medicine—in fact, more manifestly so—architecture is both an art and a science. Its art, often described synesthetically as frozen music, is apparent to everyone who stops to look. Its science is obvious to anyone who pauses to think. Like medicine, architecture also carries, albeit less conspicuously, a humanistic component. It responds to the emotional needs and the longings of the human spirit. In this, it indirectly shares with medicine a concern with human health needs. One such concern is windows, or rather windowlessness, in public buildings. The problem is not a lack of ventilation or illumination—these are taken care of by air conditioning and artificial lighting—but the absence of an outlet for human visual curiosity. Wilson<sup>1</sup>described the effect of this sensory deprivation on health in 1972. He compared the incidence of postoperative delirium in two neighboring intensive care units that resembled each other in all respects save
Target Organs and Systems: Methodologies to Assess Immune System Function
Authors: Meryl H. Karol
Journal: Environmental Health Perspectives (1998)

Immunotoxicity encompasses both reduced and heightened immune function.Diverse chemicals can impair functioning of the immune system.Both monographs and books have been devoted to detailed descriptions of immunotoxicity.This paper gives a brief overview of the methods currently used to assess the immunotoxic potential of chemicals.It also discusses the trend toward the use of alternative methods to mammalian models, such as feral species, in vitro assays, and computational models.The strategy of using a tier approach to screen chemicals for immunotoxicity is described, together with the rationale for, and limitations of, this approach.Interpretation of data with regard to clinical disease and human health is addressed.The immune system poses substantial complexities in this regard as the system has functional reserve and functional redundancy.
Statistics in Japanese Universities
Authors: P. K. Ito
Journal: Environmental Health Perspectives (1979)

The teaching of statistics in the U.S. and Japanese universities is briefly reviewed. It is found that H. Hotelling's articles and subsequent relevant publications on the teaching of statistics have contributed to a considerable extent to the establishment of excellent departments of statistics in U.S. universities and colleges. Today the U.S. may be proud of many well-staffed and well-organized departments of theoretical and applied statistics with excellent undergraduate and graduate programs. On the contrary, no Japanese universities have an independent department of statistics at present, and the teaching of statistics has been spread among a heterogeneous group of departments of application. This was mainly due to the Japanese government regulation concerning the establishment of a university. However, it has recently been revised so that an independent department of statistics may be started in a Japanese university with undergraduate and graduate programs. It is hoped that discussions will be started among those concerned on the question of organization of the teaching of statistics in Japanese universities as soon as possible.
Blockade of lectin-like oxidized low-density lipoprotein receptor reduces myocardial infarction size after ischemia-reperfusion Kazuaki Kataoka, Ryuji Nohara, Koji Hasegawa, Tetsuhiko Yanazume, Taku Hirai, Tatsuya Sawamura, Masatoshi Fujita, Shigetake Sasayama. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Japan
Journal: Journal of the American College of Cardiology (2001)
PLoS Medicine Issue Image | Vol. 4(6) June 2007
Journal: PLoS Medicine (2007)

This 1941 image of factory workers assembling storage batteries takes its theme from this month's editorial, "The Changing Face of Occupational Medicine." The editorial topic was suggested by the Policy Forum by Corita Grudzen and Peter Kerndt (Grudzen CR, Kerndt PR [2007] The adult film industry: Time to regulate? PLoS Med 4: e126 doi:10.1371/journal.pmed.0040126) on the need for the adult film industry to self-regulate to protect workers' rights and for occupational medicine to adapt to the requirements of workers today. Image Credit: Image provided by the US Centers for Disease Control, from the Public Health Bulletin No. 262, 1941
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1960)

COMMITTEE ON MATERNAL WELFARE*Paralytic IleusA twenty-one-year-old gravida 2, para 1, was admitted to the hospital with painless bleeding in the thirty-eighth week. Under double-setup precautions partial premature separation of the placenta was diagnosed, but the cervix was found "unfavorable" and a lower-segment cesarean section was done. She died four days later.There had been only four prenatal visits, all with normal findings, three to seven weeks apart, the last at thirty-five weeks. Then the return appointment was set for a full calendar month later, — that is, six days before the estimated date of confinement, — but admission . . .
DNA Adducts as Exposure Biomarkers and Indicators of Cancer Risk
Authors: Miriam C. Poirier
Journal: Environmental Health Perspectives (1997)

Quantitation of DNA adducts in human tissues has been achieved with highly sensitive techniques based on adduct radiolabeling, antisera specific for DNA adducts or modified DNA, and/or adduct structural characterization using chemical instrumentation.Combinations of these approaches now promise to elucidate specific adduct structures and provide detection limits in the range of 1 adduct/109 nucleotides.Documentation of human exposure and biologically effective dose (i.e., chemical bound to DNA) has been achieved for a wide variety of chemical carcinogens, including polycyclic aromatic hydrocarbons (PAHs), aromatic amines, heterocyclic amines, aflatoxins, nitrosamines, cancer chemotherapeutic agents, styrene, and malondialdehyde.Due to difficulties in exposure documentation, dosimetry has not been precise with most environmental and occupational exposures, even though increases in human blood cell DNA adduct levels may correlate approximately with dose.Perhaps more significant are observations that lowering exposure results in decreasing DNA adduct levels.DNA adduct dosimetry for environmental agents has been achieved with dietary contaminants.For example, blood cell polycyclic aromatic hydrocarbon-DNA adduct levels were shown to correlate with frequency of charbroiled meat consumption in California firefighters.In addition, in China urinary excretion of the aflatoxin B1-N7-guanine (AFB,-N7-G) adduct was shown to increase linearly with the aflatoxin content of ingested food.Assessment of DNA adduct formation as an indicator of human cancer risk requires a prospective nested case-control study design.This has been achieved in one investigation of hepatocellular carcinoma and urinary aflatoxin adducts using subjects followed by a Shanghai liver cancer registry.Individuals who excreted the AFB1-N7-G adduct had a 9.1-fold adjusted increased relative risk of hepatocellular carcinoma compared to individuals with no adducts.Future advances in this field will be dependent on chemical characterization of specific DNA adducts formed in human tissues, more precise molecular dosimetry, efforts to correlate DNA adducts with cancer risk, and elucidation of opportunities to reduce human DNA adduct levels.