tbuckley/cabot-search huggingface dataset:
Low-dose chemotherapy with central nervous system prophylaxis and zidovudine maintenance in AIDS-related lymphoma. A prospective multi-institutional trial
Authors: A M Levine, J C Wernz, L Kaplan, N Rodman, P Cohen, C Metroka, J M Bennett, M U Rarick, C Walsh, J Kahn
Journal: JAMA (1991)

--To ascertain if low-dose multiagent chemotherapy, with central nervous system prophylaxis and antiretroviral therapy, might be associated with increased efficacy and decreased risk of intercurrent infection in patients with malignant lymphoma related to the acquired immunodeficiency syndrome (AIDS).--A phase II prospective clinical trial, with median follow-up of 33 months.--Eight university hospitals, within the context of the AIDS Clinical Trials Units, sponsored by the National Institute of Allergy and Infectious Diseases.--Forty-two patients with AIDS-related malignant lymphoma. All were evaluable for toxicity assessment, and 35 for response.--A low-dose modification of the M-BACOD regimen (day 1): cyclophosphamide, 300 mg/m2 intravenously (IV); doxorubicin, 25 mg/m2 IV; vincristine sulfate, 1.4 mg/m2 IV; bleomycin, 4 mg/m2 IV; dexamethasone, 3 mg/m2 orally on days 1 through 5; methotrexate, 500 mg/m2 IV on day 15, with leucovorin rescue. Intrathecal cytosine arabinoside (50 mg) to all on days 1, 8, 21, and 28, with radiation therapy to a helmet field to those with central nervous system involvement. Zidovudine for 12 months after completion of four to six cycles of chemotherapy.--Response rate and number of opportunistic infections.--Response rate was 51% with a complete response of 46%. Of 16 complete responses, relapse occurred in four, none isolated to the central nervous system. Opportunistic infections occurred in 21% of those receiving treatment. Median duration of survival among all 42 patients is 5.6 months, 6.5 months in 35 patients evaluable for response, and 15 months in patients with complete response. Lower concentration of CD4 cells, history of prior AIDS, bone marrow involvement, and stage IV disease were independently associated with decreased survival.--Low-dose chemotherapy with central nervous system prophylaxis and zidovudine maintenance may be associated with durable remissions in AIDS-related lymphoma with fewer opportunistic infections than noted in prior reports.
Urinary Incontinence
Authors: Guy W. Leadbetter
Journal: New England Journal of Medicine (1963)

INVOLUNTARY leakage of urine invariably causes a patient or the parents of a patient so afflicted to seek relief. Loss of urine may be complete, partial or noted only on stress. The degree makes little difference. Incontinence is not due to a single factor but to a variety of congenital, neurologic, traumatic and surgically induced conditions, and any plan for therapy must be based on an accurate knowledge of the anatomic or physiologic factors responsible.Probably the best way of approaching the subject of therapy is to characterize incontinence as either congenital or acquired. Congenital malformations causing incontinence include patent . . .
Biochimica et Biophysica Acta, Amsterdam
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diffuse Malignant Pleural Mesothelioma: Clinicopathological Study of Ten Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of hypertension with spironolactone. Double-blind study
Authors: R. L. Wolf
Journal: JAMA (1966)

A double-blind study of patients with essential hypertension was performed in order to determine which dosage of spironolactone (25 mg, 100 mg, or 200 mg daily), with or without hydrochlorothiazide, had the optimum hypotensive effect. The data were analyzed by two different statistical methods, in each of which multivariate analysis of variance was used. Both methods led to the conclusion that the most efficacious treatment regimen tested was spironolactone at a daily dosage of 100 mg, without hydrochlorothiazide.
<i>A practical Manual of Mental Medicine</i>. By Da. E. Régis, formerly Chief of Clinique of Mental Diseases. Paris; formerly Assistant Physician of the Sainte Anne Asylum; Physician of the Maison de Santé de Castel d'Anterre; Laureate of the Medico-Psychological Society, and of the Faculty of Medicine of Paris; Professor of Mental Diseases, Faculty of Medicine. Bordeaux. With a Preface by M. Benjamin Ball, Clinical Professor of Mental Diseases, Paris. A work crowned by the Faculty of Medicine …
Authors: W. L. W.
Journal: American Journal of Psychiatry (1894)
Rugby Injuries
Authors: Barrie Abrahams
Journal: British Journal of Sports Medicine (1977)

In infection with the helminth Schistosoma mansoni, parasite eggs elicit a Th cell-mediated hepatic granulomatous inflammation that leads to scarring, portal hypertension, hemorrhage, and death. On the other hand, the cytokine IL-10 has been shown to decrease egg Ag-specific Th cell responses by down-regulating MHC class II as well as B7 costimulatory molecule expression on accessory cells. We now test the effect of IL-10 in vivo on models of egg Ag-specific hypersensitivity as well as on the natural disease. Systemic administration of IL-10 significantly inhibited delayed-type hypersensitivity reactions to egg Ag as well as primary and secondary granuloma formation to eggs embolized in the lung. However, significant inhibition of hepatic granuloma formation associated with the natural infection required the use of an IL-10/Fc fusion protein with a prolonged in vivo half-life. Lymph node cells from IL-10/Fc-treated mice produced less IL-2 and IFN-gamma, and more IL-4 and IL-10 than control cells, suggesting that reduced egg granuloma formation resulted primarily from down-regulation of Th1 responses. These results indicate that suitable administration of exogenous IL-10 can be effective in ameliorating immunopathologic damage associated with schistosomiasis.
An unusual vascular complication of fractured clavicle
Authors: P. H. Guilfoil
Journal: JAMA (1967)

SEVERAL well-recognized vascular injuries are quite commonly associated with bony trauma. Posterior dislocation of the knee may result in severe contusion or even actual laceration of the popliteal artery.<sup>1</sup>Numerous cases of rupture of the axillary artery in association with anterior dislocation of the shoulder have been reported.<sup>2</sup>Aneurysmal dilatation of the subclavian artery following fracture of the clavicle was reported recently by DeBakey et al.<sup>1</sup>Also, Gryska has recorded the case of a patient in whom a clavicular fracture was complicated by complete transection of the subclavian artery.<sup>3</sup>We have not, however, been able to find a report which describes subclavian artery thrombosis as a sequel of nonunited fracture of the clavicle. <h3>Report of a Case</h3> A 55-year-old white man was admitted to the Veterans Administration Center, Dayton, Ohio, on Sept 1, 1966. At the time of admission he was semistuporous and had a strong
Carotid Artery Surgery in the Prevention of Stroke
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CRST Syndrome.
Authors: Richard D. Carr
Journal: Annals of Internal Medicine (1966)

s1 May 1966CRST Syndrome.Richard D. Carr, M.D., Eldred B. Heisel, M.D.Richard D. Carr, M.D.Search for more papers by this author, Eldred B. Heisel, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1174_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe CRST syndrome is a recently defined symptom-complex consisting of (1) calcinosis cutis, (2) Raynaud's phenomenon, (3) sclerodactyly and (4) telangiectasis closely resembling hereditary hemorrhagic telangiectasis. Seven cases observed by the authors during the past year are presented in tabular form in regard to clinical findings, laboratory abnormalities, and histopathology. Specimen photographs and roentgenographic slides illustrating the characteristic findings are shown.Comparison of the CRST syndrome with the common acrosclerotic type of scleroderma is made, revealing several common features and a basic similarity between the two. The CRST syndrome does appear to pursue a prolonged and more benign course. However,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1174-1174KeywordsClinical laboratoriesHistopathologyRaynaud syndromeResearch laboratoriesScleroderma Issue Published: 1 May 1966 PDF DownloadLoading ...
EXOPHTHALMIC GOITER.
Authors: F. W. HIGGINS
Journal: JAMA (1900)

This is one of those puzzling and tantalizing diseases which will baffle a full explanation. All disease is mysterious, but we are beginning to feel that the pathology if not the treatment of diphtheria, Bright's disease, or tuberculosis is somewhat satisfactory. Many diseases of the nervous system have a beautifully exact anatomical lesion. But exophthalmic goiter, one of the most striking entities of them all, is most elusive. The symptoms are fairly definite and yet I believe that the disease often remains unrecognized. This is so for the reason that one or more of the main symptoms may be absent or slightly in evidence. The rapid pulse is the most constant and easily detected. A pulse above one hundred, when the patient is not excited or under exertion, should arouse suspicion of this disease. Still, this marked symptom is absent in a certain percentage of cases. The enlarged thyroid, which
Advisory Committee Meeting
Authors: Jane E. Henney
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neck lumps
Authors: Benjamin Davies, Mark Felton, Andrew Camilleri
Journal: BMJ (2014)

A practical guide to differentiating lumps in the neck Neck swellings are a common clinical occurrence and often feature in medical student examinations. The neck contains many different structures, which can give rise to swellings, both benign and serious. Accurate differentiation requires a thorough history taking and examination. This article aims to help students understand the anatomy of the neck and to differentiate the common causes of neck swelling. While taking a history, you should ask about the swelling, associated symptoms, and medical, family, and social history (box 1).345 Although many characteristics of the swelling will be discovered during an examination, this only represents a clinical snapshot. Questions about the onset and development of swellings, including any tenderness or variation in size, are informative in the differential diagnosis. A patient’s concerns and expectations should be explored, which may aid subsequent explanation of possible differential diagnoses and therefore further investigations. #### Box 1 Important features to be considered while taking a history for neck swelling123 ##### Describing the swelling ##### Associated symptoms (possible diagnosis) ##### Medical history ##### Family history ##### Social history
PLUGGING NOSTRILS WITH COTTON AS PROTECTION AGAINST DISEASES CONTAGIOUS BY INHALATION
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of Vincristine Pharmacokinetics (PK) in Adolescent/Young Adult (AYA) Versus Younger Patients Defined By Tanner Stage during Treatment for Acute Lymphoblastic Leukemia (ALL)
Authors: Leidy L Isenalumhe, Ashley S. Margol, Stan Louie, Michael Neely, Richard Sposto, Jemily Malvar, David Robert Freyer
Journal: Blood (2015)
Points: Augmentin (amoxycillin-clavulanic acid) compared with co-trimoxazole in urinary tract infection
Authors: S G F. Matts, K MacRae
Journal: BMJ (1984)

determined by the degree with which death is desired.For those who dread it, time rushes by; there is no time to do everything, as with a student approaching his finals, or a condemned man his execution.For those who have had enough of life and welcome death, time hangs heavy, as with a child awaiting Christmas Day.As Sarah, Duchess of Marlborough was wont to sigh in crippled old age, "If I could have walked out of this world, I would have departed long ago."'I Green D. Sarah, Duchess of
Treatment of Total Hyphema with Fibrinolysin
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pavlov Revisited
Authors: Vincent J. Derbes
Journal: JAMA (1984)

ACCORDING to the<i>Encyclopaedia Britannica</i>, Ivan Petrovich Pavlov (1849-1936) is known for his development of the concept of the conditioned reflex. True enough, but was he the first to whom this idea came? At least one thinker antedated him by some 650 years. I quote from K. P. Harrington's<i>Mediaeval Latin</i>, University of Chicago Press, 1962: "Jacques de Vitry was born somewhere in France in the latter part of the twelfth century, and advanced in the church until he became Bishop of Acon in Palestine in 1216, where he remained for several years. In 1227 he was made Cardinal Bishop of Tusculum, and died in 1240. He was a celebrated preacher and has left several volumes of sermons including the Sermones Communes sive Cotidiani and the Sermones Vulgares." I translate Exempla 38 from the latter. "I have heard that a certain prelate in France had a quite superior horse; his
XX. THE NONSPECIFIC REACTION
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COLLAGEN DISEASES
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LONDON
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal