tbuckley/cabot-search huggingface dataset:
Abstract 3274: LTX-401 as a novel antitumor and immunotherapeutic agent in an experimental liver cancer model
Authors: Brynjar Mauseth, Ketil Camilio, Ji-Hua Shi, Øystein Rekdal, Baldur Sveinbjørnsson, Pål-Dag Line
Journal: Cancer Research (2019)

Abstract Liver cancer is estimated to be the third most common cause of cancer-related mortality worldwide in both sexes. Hepatocellular carcinoma (HCC) is the most prevalent type of primary liver cancer in which potential curative surgical options are limited and overall survival poor. Hence, there is an unmet need for new and improved therapies. LTX-401 is a novel oncolytic compound with potent antitumor properties. Owing to its amphiphatic nature, LTX-401 may affect the integrity of cancer cell membranes and induce rapid cell death. Transmission electron microscopy indeed revealed a necrotic cell death phenotype accompanied by massive vacuolization of the cytoplasm and dilated mitochondria. Additionally, LTX-401 induces features of immunogenic cell death (ICD) as seen by the extracellular release of ATP and HMGB1, as well as the mitochondrial DAMP cytochrome C. The antitumor effects of LTX-401 has been explored in an experimental model of hepatocellular carcinoma (JM1 model) using immunocompetent rats. When injected into subcutaneously established lesions, the majority of animals went into remission followed by systemic protective immune responses. Additionally, LTX-401 could affect the growth of distal tumor deposits simulating metastases, hence indicating immune-mediated abscopal responses. Intratumoral treatment of orthotopic liver tumors resulted in cure of approximately half of the animals treated, which later displayed protection against subcutaneous tumor (re)challenge. Splenocytes harvested from immunized animals produced significantly larger amounts of IFN-y when stimulated with tumor cells ex vivo, indicating the presence of tumor-specific (memory) T cells. Histological examinations revealed that LTX-401 caused massive hemorrhagic tumor necrosis, both in subcutaneous and intrahepatic compartments, followed by increased infiltration of T cells. Taken together these results indicate that oncolytic compounds generate an immunogenic tumor environment and may be therapeutically exploited as a novel antitumor and immunotherapeutic approach in HCC. Citation Format: Brynjar Mauseth, Ketil Camilio, Ji-Hua Shi, Øystein Rekdal, Baldur Sveinbjørnsson, Pål-Dag Line. LTX-401 as a novel antitumor and immunotherapeutic agent in an experimental liver cancer model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3274.
MEDICAL PRACTICES IN SOME PHILIPPINE PROVINCES
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and safety of telotristat ethyl in patients with carcinoid syndrome inadequately controlled by somatostatin analogs: Analysis of the completed TELESTAR extension period
Authors: D. Hörsch, M.H. Kulke, M. Caplin, L. Anthony, E. Bergsland, K. Öberg, R.R.P. Warner, P. Kunz, E. Grande Pulido, J.W. Valle, J.S. Dillon, P. Lapuerta, P. Banks, S. Jackson, M. Pavel
Journal: Annals of Oncology (2017)
<i>QuickStats</i>: Percentage*<sup>,†</sup> of Men and Women Aged 25–49 Years Who Spent at Least One Night in the Past 12 Months at an Alternate Location Because They Did Not Have a Permanent Place To Stay, by Type of Location§ — National Survey of Family Growth, United States, 2017–2019
Journal: MMWR Morbidity and Mortality Weekly Report (2021)
Penicillin V for Group A Streptococcal Pharyngotonsillitis
Authors: Richard H. Schwartz
Journal: JAMA (1981)

The effect of duration of orally administered penicillin V potassium on the bacteriologic and clinical cure of group A streptococcal pharyngitis was evaluated. One hundred ninety-one middle-class patients received either seven days (96 patients) or ten days (95 patients) of therapy. Compliance with taking penicillin was assessed by multiple methods, including penicillinuria. Throat cultures were obtained during therapy and three times in the three weeks after therapy. M-precipitin and T-agglutinin typing were done on paired isolates of group A streptococci from patients who had recurrences. Patients treated for seven days had a significantly greater failure rate (30/96 [31%]) compared with patients receiving ten days of penicillin (17/95 [18%]). Compliance rates were high; 66% to 81% of patients showed penicillinuria throughout the study period. Treatment failure was not a function of poor compliance in either treatment group. The data support the current recommendation for ten full days of penicillin therapy and suggest that persistence of streptococci in the throat after adequate therapy may be common. (<i>JAMA</i>1981;246:1790-1795)
THE GRADUATING AGE IN MEDICINE.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells
Authors: G Kullak-Ublick
Journal: Hepatology (1996)

Bile acids are taken up into human liver by Na+-dependent and Na+-independent transport mechanisms. In hepatocarcinogenesis, numerous liver-specific functions are lost and the uptake of organic anions is markedly reduced. We have investigated the molecular and functional derangements of bile acid transport in the human hepatoblastoma cell line HepG2. Uptake of [3H]-taurocholic acid was saturable and entirely Na+ independent, with the kinetic characteristics of the human liver organic anion transporting polypeptide (OATP). OATP, but not the Na+-dependent bile acid transporter (Na+-taurocholate-cotransporting polypeptide [NTCP]), was detectable by reverse-transcription polymerase chain reaction (RT-PCR) analysis of HepG2 RNA. The level of OATP expression in HepG2 cells was determined by Northern blot analysis and was found to be 40% in comparison with normal liver. Transfection of an OATP-derived phosphorothioate (PTO)-antisense oligonucleotide into HepG2 cells resulted in 77% inhibition of temperature-dependent bile acid uptake. Injection of HepG2 messenger RNA (mRNA) into Xenopus laevis oocytes significantly stimulated Na+-independent taurocholate uptake, indicating the expression of a bile acid transport protein. We conclude that bile acid uptake into human hepatoblastoma HepG2 cells is mediated by the multi-specific organic anion transporting polypeptide OATP. Therapeutic strategies employing bile acid-derived cytostatic agents for the treatment of hepatocellular carcinomas may therefore depend upon the expression of the Na+-independent bile acid transporter OATP in hepatic malignancies.
The Physician's Visiting List (Lindsay and Blakiston's) for 1918. Leather.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;emph&gt;Medical News&lt;/emph&gt;
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: J. Boer
Journal: British Journal of Dermatology (1988)

Journal Article Reply Get access J. Boer J. Boer Department of Dermatology, Deventer Hospitals, Postbox 5001, 7400 GC Deventer, The Netherlands. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 118, Issue 1, 1 January 1988, Pages 135–136, https://doi.org/10.1111/j.1365-2133.1988.tb01765.x Published: 01 January 1988
DR. GRENFELL OF LABRADOR.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Determination of Point Mutational Spectra of Benzo[a]pyrene-diol Epoxide in Human Cells
Authors: Phouthone Keohavong, William G. Thilly
Journal: Environmental Health Perspectives (1992)

The primary goal of our research consists of developing means sufficiently sensitive to allow assessment of human exposure to environmental carcinogens. We describe here a new approach for analyzing point mutational spectra and a test for its validity and precision using cultured human cells exposed to high doses of environmental carcinogens. The approach in its present form includes a) treatment of independent large cultures of human cells with a carcinogen, b) selection of mutant cells en masse by 6-thioguanine resistance, c) amplification of sequences of interest directly from 6TGR cells using high-fidelity polymerase chain reaction, and d) separation of mutant sequences from nonmutant sequences using denaturing gradient gel electrophoresis. We report use of this protocol to observe induced mutational spectra in exon 3 of the hprt gene in cultured human cells by benzo[a]pyrene-diol epoxide (BPDE), an active form of the widely distributed environmental carcinogen benzo[a]pyrene. BPDE induced predominantly G to T transversions within this target sequence. The variation of the frequency of the mutations among independent cultures is consistent with the interpretation that each of them corresponds to a hotspot.
Abstract 2442: Assessing how macrophages attain distinct iron handling phenotypes in a tumor via a mathematical model
Authors: Luis Sordo Vieira, Joseph Masison, Jacqueline Adams, Suzy Torti, Reinhard Laubenbacher, Julia Chifman
Journal: Cancer Research (2019)

Abstract Tumor-associated macrophages are critical regulators of iron levels. It is well established that macrophages display distinct iron handling phenotypes based on the several signals they receive from other cells in the tumor microenvironment. In order to shed light on how macrophages respond to these different signals, we are building a knowledge-based mathematical model for how macrophages attain distinct, yet related, iron handling capabilities. Citation Format: Luis Sordo Vieira, Joseph Masison, Jacqueline Adams, Suzy Torti, Reinhard Laubenbacher, Julia Chifman. Assessing how macrophages attain distinct iron handling phenotypes in a tumor via a mathematical model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2442.
Der Stoffaustausch zwischen Mutter und Frucht durch die Placenta.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcomes in critical care medicine
Authors: R. C. Bone
Journal: JAMA (1988)

As the costs of health care have risen, attention has focused on the analysis of the quality and outcomes of health care. In this issue ofTHE JOURNAL, Reynolds et al<sup>1</sup>evaluated the effects of changing the physician staffing in a medical intensive care unit (MICU) so that the staff consisted of dedicated critical care medicine (CCM) staff physicians and postresidency trainees in critical care. The impact of these changes on treatment patterns, morbidity and mortality, and hospital charges of patients with a single disease entity (septic shock) was studied during two periods. Two groups of patients were compared: those treated by faculty without CCM training who supervised the MICU and patients treated by physicians formally trained in CCM and postresidency CCM fellows. Mortality was lower during the post-CCM period (74% vs 57%). The authors concluded that the implementation of dedicated staffing by CCM physicians in a university hospital
Alcohol and Other Drug Use Among High School Students—United States, 1990
Journal: JAMA (1991)

Use of alcohol and other drugs is associated with the leading causes of death and injury (e.g., motor-vehicle crashes, homicides, and suicides) among teenagers and young adults; for example, nearly half of all deaths from motor-vehicle crashes in this age group involve alcohol use (1,2). This article presents self-reported data about the prevalence of alcohol, marijuana, and cocaine use among U.S. students in grades 9-12 during 1990.
Postexercise Peril
Authors: Jerome L. Fleg
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Dimsdale et al attempt to make a quantum leap between the laboratory and the real world with little supporting evidence. They demonstrate approximately a 50% increase in norepinephrine levels and less than 30% increase in epinephrine levels from peak effort to the immediate postexercise period in ten healthy men. They suggest that these elevations provide "a possible mechanism for the increased risk of cardiac arrhythmias and ischemia during the cool-down period after strenuous exercise." Although the ECG was apparently monitored throughout the test, no mention of ectopic activity prevalence or time of occurrence is given—the crucial data needed to test their hypothesis. In a prior study from one of the authors, ventricular ectopic beats occurred 2.5 times more frequently during exercise than during recovery in a large sample of apparently normal subjects.<sup>1</sup>This is the same reference given to support the statement that serious cardiac events
British Medical Journal
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Masthead: (Adv. Healthcare Mater. 17/2016)
Journal: Advanced Healthcare Materials (2016)

Citizenship: Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those in need, enhancing community philanthropy, reducing our carbon impact, creating global guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our efforts.
PWE-184 Prevalence, management and outcomes of patients with coagulopathy following acute non-variceal upper gastrointestinal bleeding
Authors: V Jairath, B Kahan, R Logan, S Hearnshaw, S Travis, M Murphy, K Palmer
Journal: Gut (2012)

<h3>Introduction</h3> There is increasing interest in optimising transfusion strategies in patients with major haemorrhage. In other models of haemorrhage such as trauma, an endogenous coagulopathy early in the disease course is associated with increased mortality, with subsequent implications for transfusion management. Non-variceal upper gastrointestinal bleeding (NVUGIB) is a leading cause of admission with haemorrhage and for transfusion of blood components. The impact of coagulopathy in this group is poorly characterised. We characterised in patients presenting with NVUGIB 1) the epidemiology of a key marker of coagulopathy, a prolonged International Normalised Ratio (INR) and the association of coagulopathy with patient survival and other key clinical outcomes. <h3>Methods</h3> We used data from the 2007 UK national audit of acute upper gastrointestinal bleeding (AUGIB) and the use of blood. We included those patients with endoscopically confirmed NVUGIB and excluded those with documented cirrhosis. Coagulopathy was defined as an INR&gt;1.5. A logistic regression model was used to compare risk adjusted clinical outcomes in those patients with coagulopathy vs those without coagulopathy. <h3>Results</h3> An INR at presentation was performed in 61% (2709/4478) of patients with NVUGIB. The prevalence of coagulopathy (INR ≥1.5) was 16.4% (444/2709). Patients with coagulopathy were older, more likely to present with shock (45% vs 36%), have a higher clinical Rockall (4 vs 2), more likely to have high risk stigmata at endoscopy and more likely to be transfused both red blood cells (70% vs 48%) and FFP (35% vs 3%). 8% (220/2709) of all patients who had an INR recorded received FFP transfusion during their admission. In those patients with an INR of <h3>Conclusion</h3> An early coagulopathy is prevalent in patients presenting with acute NVUGIB and is independently associated with in-hospital mortality. The wide variation in the use of FFP to correct this suggests clinical uncertainty regarding best practice. <h3>Competing interests</h3> None declared.