tbuckley/cabot-search huggingface dataset:
Physical Diagnosis.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P200: Estimating the Receiver Operating Characteristics (ROC) Curve and its Associated AUC in Matched Case Control Studies
Authors: Raji Balasubramanian, Hui Xu, Brian W Whitcomb, Susan E Hankinson, Nina Paynter, Kathryn M Rexrode, Jing Qian
Journal: Circulation (2017)

Background: The matched case-control study design is frequently used in cardiovascular disease research and can result in significant gains in efficiency; however, prediction in this setting is not straightforward. We propose an inverse-probability weighting approach to estimate the predictive ability associated with a set of covariates. Methods: We consider AUC estimation in 1:m matched case control studies and compare its bias with logistic regression in simulations. Let X denote the vector of exposures, Z the vector of matching factors and Y the binary outcome. We assume the population logistic model: logit [Pr(Y = 1
Trimethoprim-sulfamethoxazole vs ampicillin in chronic urinary tract infections. A double-blind multicenter cooperative controlled study
Authors: R. A. Gleckman
Journal: JAMA (1975)

A multicenter, prospective, double-blind, controlled study was performed to compare the efficacy of trimethoprim-sulfamethoxazole with that of ampicillin in the treatment of chronic urinary tract infections. The incidence of adverse clinical signs and symptoms as well as abnormal laboratory values were comparable in the two treatment groups. This study appears to establish the fact that trimethoprim-sulfamethoxazole is an acceptable alternative to ampicillin for the treatment of chronic urinary tract infections caused by susceptible<i>Escherichia coli</i>. (<i>JAMA</i>233:427-431, 1975)
Abstract 3150: Impact of interleukin-1 alpha and EGFR expression on recurrence and survival outcomes in head and neck squamous cell carcinomas
Authors: Andrean L. Simons, Anand Rajan, Katherine Gibson-Corley, Georgina Ofori-Amanfo, Patrick Ten Eyck, Madelyn Espinosa-Cotton, Sandra Schmitz, Joseph Coppock, Steven Sperry
Journal: Cancer Research (2019)

Abstract Interleukin-1 alpha (IL-1α) is a pleiotropic cytokine involved in inflammation and immune response and is upregulated in many solid tumors including head and neck squamous cell carcinomas (HNSCCs). Although IL-1α expression is generally associated with poor prognosis, the implications of the subcellular localization of IL-1α expression in patient outcomes are poorly understood. This study is aimed at investigating the clinical relevance of immunohistochemical IL-1α expression in HNSCCs. Tissue microarrays (TMAs) containing human papillomavirus (HPV)-positive and HPV-negative HNSCCs were analyzed for IL-1α and epidermal growth factor receptor (EGFR) expression by immunohistochemistry. Nuclear and cytoplasmic IL-1α and EGFR expression scores were correlated with clinicopathological parameters and patient outcomes. IL-1α expression was observed in the nuclear and/or cytoplasm compartments in 98% of evaluable tumors and 78% of tumors expressed IL-1α in both compartments. A higher percentage of tumors with combined high nuclear and moderate cytoplasmic IL-1α expression were observed in HPV-negative tumors compared to HPV-positive tumors. In HPV-negative tumors a combined EGFR-negative and high nuclear IL-1α expression profile was associated with a low risk of tumor recurrence and favorable overall survival compared to all other EGFR/IL-1α expression profiles. Lastly, a higher frequency of tumors with combined high nuclear and moderate cytoplasmic IL-1α expression was observed in cetuximab monotherapy responders compared to non-responders. Altogether, IL-1α in combination with EGFR expression may be a strong indicator of risk of recurrence in HPV-negative HNSCCs and warrants further study as a tissue biomarker for predicting HNSCC patient outcomes. Citation Format: Andrean L. Simons, Anand Rajan, Katherine Gibson-Corley, Georgina Ofori-Amanfo, Patrick Ten Eyck, Madelyn Espinosa-Cotton, Sandra Schmitz, Joseph Coppock, Steven Sperry. Impact of interleukin-1 alpha and EGFR expression on recurrence and survival outcomes in head and neck squamous cell carcinomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3150.
银屑病患者的葡萄糖代谢
Authors: N.U. Friis, N. Hoffmann, M. Gyldenløve, L. Skov, T. Vilsbøll, F.K. Knop, H. Storgaard
Journal: British Journal of Dermatology (2019)

多项大规模流行病学(基于人群)研究得出的结论表明,银屑病会增加 2 型糖尿病 (T2D) 的发病风险。我们的主要目标是确定临床研究获得的数据是否支持银屑病和 2 型糖尿病有共同发病机制的观点。因此,我们评论了探讨银屑病患者葡萄糖代谢情况的临床研究。我们也对目前有关银屑病可能如何导致 2 型糖尿病的理论观点进行了介绍。26 项报告了胰岛素抵抗、葡萄糖耐受或胰岛素分泌等内容的临床研究符合文献评论条件。不到一半研究得出的结果表明,银屑病患者的葡萄糖代谢存在缺陷。总的来说,这些研究缺少相应研究如何对 2 型糖尿病已知风险因素加以考虑的信息。此外,研究方法各不相同,除了一项研究之外,其他所有研究可能都不适合检测出早期和微小的葡萄糖代谢缺陷。探讨银屑病患者葡萄糖代谢情况的临床研究得出的结果存在分歧,目前明确得出结论认为银屑病与 2 型糖尿病有共同的发病机制还为时尚早。然而,结合流行病学文献以及所提出的有共同发病机制的理论,我们认为目前有充足的依据支持在该领域进一步开展研究。新的研究需要采用合理的方法和精心设计的研究技术,从而深入了解银屑病患者的葡萄糖代谢情况。
Severed Cords
Authors: Jason David Eubanks
Journal: Annals of Internal Medicine (2009)

Ad Libitum5 May 2009Severed CordsJason David Eubanks, MDJason David Eubanks, MDFrom the University of Pittsburgh Medical Center, Pittsburgh, PA 15213.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-9-200905050-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Both her entrance and her exitWere marked by the cutting of cords—The first, a beautiful, muscular thing,Twisted hues of blue and white,Glossed in her mother'sSanguineous self,The rope that nursed her into existence,Cut and tagged—A severed cordGreeted with a life-grasping cry.The second, a more delicate thing,But a cord, nonetheless, in the hands of a mother,This time without protected carriageIn the womb's tropical waters,But, rather, piggybackingOn a bouncing ATVClinging, desperatelyTo a woman, slaphappy in the gloaming,Driving, screaming, pushing, once again,Toward a blood-covered,Maternal anesthesia.Where ... Author, Article, and Disclosure InformationAffiliations: From the University of Pittsburgh Medical Center, Pittsburgh, PA 15213.Current Author Address: Jason David Eubanks, MD, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Pittsburgh, PA 15213. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 May 2009Volume 150, Issue 9Page: 660KeywordsAnesthesiaFallsMuscular dystrophiesPharynxSleepSpinal cord ePublished: 5 May 2009 Issue Published: 5 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effect of peyote on human chromosomes. Cytogenetic study of the Huichol Indians of Northern Mexico
Authors: D. L. Dorrance
Journal: JAMA (1975)

Fifty-seven Huichol Indians with a lifelong individual history and a 1,600-year cultural tradition of ingestion of peyote, a mescaline-containing cactus possessing hallucinogenic properties, were compared with 50 Huichol Indian controls and ten laboratory controls for effects on lymphocyte chromosomes. The frequency of abnormalities in the experimental and control groups did not differ significantly. Our results indicate that multigenerational ingestion of peyote is not associated with abnormalities in lymphocyte chromosomes. (<i>JAMA</i>234:299-302, 1975)
Patient compliance.
Authors: S. Allard
Journal: BMJ (1992)

the test.There are several problems with these arguments.Firstly, studies showing the benefits of giving fuller information in health care far outnumber the few that document any adverse effects.3Secondly, the main cause of dissatisfaction among patients is being given too little informa- tion, not too much.'Thirdly, health professionals are generally poor at judging the informational and emotional needs of patients.We have used tape recordings of consultations to study the presentation of cervical screening in primary and secondary care and of maternal serum or fetoprotein screening for spina bifida and Down's syndrome (T M Marteau and S Thwaites, annual scientific meeting of Association of University Teachers of General Practice, Manchester, 15-17 July 1992).°Themost striking feature of the results of these studies is the paucity of information given during routine screening.For example, the likelihood of being recalled-a not uncommon occurrence with these screening tests-was never mentioned in over 120 consultations.The conditions for which screening was being offered were described on just five occasions.The possibility of a false negative result for either test was never mentioned.Brief training programmes to improve the ways in which health professionals present routine screening tests are currently being evaluated.Meanwhile, the development of guidelines on the minimum information patients should be given before they consent to screening is a worthy objective.Aside from increasing patients' under- standing of the tests they are being offered, provision of more detailed information may also minimise both raised anxiety and false reassurance, two common problems for those undergoing screening.Guidelines define good practice.This inevitably defines less good practice.Avoidance of bad practice may encourage defensive medicine, since some doctors may be encouraged to give informa- tion only because they fear litigation.The function of any such guidelines, however, is to improve the quality of services to patients prospectively.It is sad if we shrink from defining good practice purely out of fear that it defines and exposes poor practice.
Correction
Journal: BMJ (1924)

drug will be manufactured by the Powers-Weightman-Rosengarten Co. of Philadelphia, and will become available through the regular trade channels about January 1st, 1925.In releasing the drug for the benefit of the public, the Rockefeller Institute desires it to be known that the Institute does not share in any way in profits that may be derived from the sale of the drug, and that, with the cordial co-operation of the manufacturers, provision has been made for the main- tenance of a schedule of prices on as low a basis as possible.THE annual report for 1923-24 of Livingstone College, Leyton, draws attention to the fact that it is now thirty-two years since the Collegle was founded to give medical instruc- tion to candidates for the mission field.During that time
Aspirin Prophylaxis for Thrombosis
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HYPERPLASTIC SUBCONJUNCTIVITIS.
Authors: H. McI. MORTON
Journal: JAMA (1897)

As a contribution to a rare condition, I desire to present the following cases: <h3>Case 1.</h3> —A. V., white, age 35 years. The man, a tobacconist by occupation, consulted me on July 23, 1894. Until two weeks previous to this time, he had had no ocular trouble. On July 9, while riding a bicycle, he fell and was thrown into a bush by the wayside. He realized immediately that a foreign body had entered his left eye, which at once began to swell. This swelling continued so rapidly that in two days he noticed a large fleshy mass protruding from the swollen lids. He consulted his family physician, who, finding the usual antiphlogistic measures of no avail, brought him to my office, two weeks after the date of the accident. Inspection revealed great infiltration of both upper and lower palpebræ. In both lids existed an external wound, each of which
Health status of Air Force veterans occupationally exposed to herbicides in Vietnam. II. Mortality
Authors: J. E. Michalek
Journal: JAMA (1990)

The Air Force Health Study is a 20-year comprehensive assessment of the current health of Air Force veterans of Operation Ranch Hand, the unit responsible for aerial spraying of herbicides in Vietnam. This report compares the noncombat mortality of 1261 Ranch Hand veterans to that of a comparison population of 19 101 other Air Force veterans primarily involved in cargo missions in Southeast Asia but who were not exposed to herbicides. The indirectly standardized all-cause death rate among Ranch Hands is 2.5 deaths per 1000 person-years, the same as that among comparison subjects. After adjustment for age, rank, and occupation, the all-cause standardized mortality ratio was 1.0. In adjusted cause-specific analyses, we found no significant group differences regarding accidental, malignant neoplasm, and circulatory deaths. These data are not supportive of a hypothesis of increased mortality among Ranch Hands. (<i>JAMA</i>. 1990;264:1832-1836)
'Contaminated' plasma: no automatic recall
Authors: C. Marwick
Journal: JAMA (1983)

Months after donating plasma, the donor comes down with acquired immune deficiency syndrome (AIDS) or symptoms that suggest it. Should the federal government recall that batch of plasma? The National Hemophilia Foundation thinks it should. On the other hand, the four commercial manufacturers that are licensed to market antihemophilic factor (AHF) in the United States maintain this could jeopardize the supply of AHF, which experience has shown to be life-saving treatment for many hemophiliacs. In a hastily-called mid-July meeting, the question was put to the seven-member Blood Products Advisory Committee of the National Center for Drugs and Biologics of the Food and Drug Administration. After considerable debate, the committee, with the help of several extra advisors, said a mechanism for a recall should not be instituted at this time. Reaching the decision was not easy. Committee members were clearly unhappy at the thought that even one unit of plasma from
UTILIZATION OF CARBON DIOXIDE BY ANIMAL TISSUES
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperbaric Oxygenation System Is Opened At Lutheran General Hospital in Park Ridge, Ill.
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid estimation of carboxyhemoglobin level in fire fighters
Authors: R. D. Stewart
Journal: JAMA (1976)

The analysis of expired breath with a portable electrochemical cell after carbon monoxide exposure provides a practical field method for the rapid estimation of carboxyhemoglobin. A fire fighter can collect and analyze his own breath sample for CO, an operation that requires 1 1/2 minutes. This simple technique has the accuracy necessary to determine compliance with the regulations governing occupational exposure to CO. (<i>JAMA</i>235:390-392, 1976)
KERATOSIS PILARIS.*
Authors: L. FORMAN
Journal: British Journal of Dermatology (1954)

Journal Article KERATOSIS PILARIS. Get access L. FORMAN L. FORMAN Dermatologist, Guy's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 66, Issue 8-9, 1 August 1954, Pages 279–282, https://doi.org/10.1111/j.1365-2133.1954.tb12634.x Published: 01 August 1954
DNA Adducts As a Measure of Lung Cancer Risk in Humans Exposed to Polycyclic Aromatic Hydrocarbons
Authors: E. Kriek, F. J. Van Schooten, M. J. X. Hillebrand, F. E. Van Leeuwen, L. Den Engelse, A. J. A. De Looff, A. P. G. Dijkmans
Journal: Environmental Health Perspectives (1993)

Workers in the coking, foundry, and aluminum industry can be exposed to high concentrations of polycyclic aromatic hydrocarbons (PAHs) and are at increased risk for lung cancer, as are cigarette smokers. In recent years several studies on workers in the foundry and coking industries have been reported. In these studies, white blood cell(WBC) DNA was used for analysis of PAH-DNA adducts. Theoretically, DNA adduct formation is a more relevant biological parameter for assessing exposure risk than PAH in the work atmosphere, or the amount of a metabolite in the urine, because adduct levels reflect that part of the dose that escapes detoxification and binds to DNA. We analyzed WBC DNA from coke-oven workers and from workers in an aluminum production plant and demonstrated the presence of PAH-DNA adducts. Forty-seven percent of the coke-oven workers had detectable levels of PAH-DNA adducts in their WBC compared with 27% of the controls (p &lt; 0.05), measured with ELISA. In both groups, smokers had significantly higher levels of PAH-DNA adducts than did nonsmokers. In the aluminum workers, no PAH-DNA adducts were detected by ELISA, although the benzo[a]pyrene concentrations in the work atmosphere were comparable to those of the coke-oven workers. The more sensitive 32P-postlabeling assay showed the presence of PAH-DNA adducts in 91% of the aluminum workers. There was no correlation of WBC adduct levels with the concentration of PAH in the work atmosphere. Recently we showed that total PAH-DNA adduct levels in WBC from lung cancer patients were much higher than those generally found in healthy smokers.(ABSTRACT TRUNCATED AT 250 WORDS)
Epistaxis
Authors: Henry H. Amsden
Journal: New England Journal of Medicine (1946)

NOSEBLEED is of frequent occurrence, often stops spontaneously and in the great majority of cases is easily controlled. It may, however, be extremely persistent and, although seldom endangering life, may cause much anxiety to both patient and physician.In the event of persistent or recurring attacks, a search should be made for some underlying cause, such as hemophilia, leukemia, anemia or diabetes. This type of nosebleed also frequently occurs in hypertension in elderly people and in affections caused by hemolytic streptococci. It should be regarded as a surgical condition, and the usual measures should be taken for its control, through . . .
Circumcision and Urinary Tract Infection
Authors: David L. Chin
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I enjoyed reading the article by Spach et al<sup>1</sup>in the February 5 issue ofThe Journal. Their findings add support to the once routine practice of circumcision. Even though the odds ratio for not being circumcised when comparing men with and without UTI was not significant (the 95% confidence interval includes 1.0), it is significant in infections with aerobic gram-negative bacilli. Two nonbacteriuric subjects were selected for each bacteriuric subject, but it is not clear how these controls were selected, or how many there were from which to choose. I also have some difficulty in understanding how the authors were able to determine the circumcision status of each of the subjects. The article does not mention whether such information is included in the clinic records. Each of these aspects could have influenced the study's results in addition to those mentioned by the authors.