tbuckley/cabot-search huggingface dataset:
Quarterly Table Reporting Alcohol Involvement in Fatal Motor-Vehicle Crashes
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The association of borderline hypertension with target organ changes and higher coronary risk. Tecumseh Blood Pressure study
Authors: S. Julius
Journal: JAMA (1990)

The Tecumseh project investigates the evolution of hypertension in a healthy population. Of 946 subjects aged 18 through 38 years, 124 had clinic blood pressure readings higher than 140/90 mm Hg (the mean for borderline hypertensive subjects was 130/94 mm Hg). Compared with normotensive subjects, borderline hypertensive subjects had higher home blood pressures (mean, 12/7 mm Hg higher). Their childhood and postpubertal blood pressures were elevated (6/4 mm Hg higher than normal at age 6 years and 12/7 mm Hg higher than normal at age 21 years), and hypertensive target organ changes were detected. Borderline hypertensive subjects also had elevated minimal forearm resistance (0.22 U higher than normal), decreased stroke index (1.8 mL/m<sup>2</sup>lower than normal), and impaired ventricular diastolic relaxation (mitral Doppler peak early diastolic blood flow [E] to peak late diastolic blood flow [A] ratio 0.13 lower than normal). Borderline hypertensive subjects had significant abnormalities in other coronary risk factors (cholesterol levels were 0.39 mmol/L higher, triglyceride levels were 0.45 mmol/L higher, high-density lipoprotein levels were 0.08 mmol/L lower, insulin levels were 38 pmol/L higher, and 16.5% more of them were overweight). Borderline hypertension is neither transient nor innocuous. Its association with other predictors of atherosclerosis calls for clinical attention. (<i>JAMA</i>. 1990;264:354-358)
Whiplash injury and brain damage: an experimental study
Authors: A. K. Ommaya
Journal: JAMA (1968)

Experimental whiplash injury in rhesus monkeys has demonstrated that experimental cerebral concussion, as well as gross hemorrhages and contusions over the surface of the brain and upper cervical cord, can be produced by rotational displacement of the head on the neck alone, without significant direct head impact. These experimental observations have been studied in the light of published reports of cerebral concussion and other evidence for central nervous system involvement after whiplash injury in man.
Nosocomial Anemia
Authors: Elaine Eyster
Journal: JAMA (1973)

Blood loss was measured and serial hematocrit readings and reticulocyte counts were performed on 93 consecutive patients. The mean daily blood loss of 54 ml was accompanied by an observed reticulocyte count of 3.4% over an average of 8.2 days. Hematocrit values in 75 patients with no evidence of bleeding decreased 5.7% during the 20.9 days of hospitalization. Of the 64 patients not anemic at the time of admission, 26 (40%) became anemic with no obvious cause prior to discharge from the hospital. Bloodletting for diagnostic studies is a significant cause of anemia and reticulocytosis in hospitalized patients.
FOOT DROP FOLLOWING LAPAROTOMY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Cardiology (2019)

Association of Changes in Income With Incident CVD 1203Higher income is associated with lower incident cardiovascular disease (CVD), but the association of changes in income with CVD is uncertain.Wang and coauthors categorized 8989 participants in the Atherosclerosis Risk In Communities (ARIC) study based on whether household income decreased more than 50%, remained unchanged/changed less than 50%, or increased more than 50% over a mean period of 6 years.In adjusted analyses, compared with individuals whose income was unchanged, those with an income drop had higher risk and those with an income rise had lower risk of incident CVD.In an Invited Commentary, Havranek discusses the influence of financial stress on health and the broader question of how physicians should respond to societal problems that lead to illness.
Addendum
Authors: J. EDWARD BERK
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 May 1973AddendumJ. EDWARD BERK, M.D.J. EDWARD BERK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-795_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: After our paper "Hyperamylasemia with Carcinoma of the Lung" (Ann Intern Med78: 521-525, 1973) was submitted for publication, we found a Japanese report dealing with amylase isoenzyme analysis in a patient with lung cancer: KITAMURA M: Amylase isoenzyme in lung cancer.Int Med29:833-837, 1972.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of California Irvine, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 795-795KeywordsLung and intrathoracic tumors Issue Published: 1 May 1973 PDF downloadLoading ...
THE RATE OF PROGRESS OF FOOD RESIDUES THROUGH THE BOWEL
Authors: WALTER C. ALVAREZ
Journal: JAMA (1924)

It would seem at first sight as if there could be little justification for another article on the rate of progress of food residues through the bowel, because today almost every physician and layman is satisfied that it takes normally from twenty-four to forty-eight hours. Every roentgenologist knows that most of the barium leaves the body within twenty-four hours, and that only traces can be seen after forty-eight hours. It appears now, however, from the studies that we have made that the giving of a large amount of indigestible material like barium with a small meal of gruel or milk must bring about unusual and abnormal conditions. The added bulk of indigestible residue may act perhaps like a large dose of agar or of liquid petrolatum, and, as is well known, patients who are being examined roentgenographically to find the cause of a severe constipation will not infrequently come back
Abstract 3094: Reclassification of pancreatic adenocarcinoma with distinct fibroblast and immune characteristics and therapeutic targets
Authors: Pawan Poudel, Cindy Neuzillet, Hemant Kocher, Anguraj Sadanandam
Journal: Cancer Research (2019)

Abstract Pancreatic ductal adenocarcinoma (PDA) with overall poor prognosis is characterized by an abundant desmoplastic stroma comprised of extracellular matrix proteins producing cancer-associated fibroblasts (CAFs). PDA treatment is still primarily based on the use of cytotoxic chemotherapies in unselected patients with modest benefit. To define biomarkers of potential treatment prediction, we (Collisson and Sadanandam; PDAssigner) defined three cancer and four intrinsic CAF (pCAFassigner; first classification to our knowledge) subtypes using PDA patient tumors and primary CAF cultures, respectively. While other groups defined up to four cancer subtypes, there exists additional unrevealed heterogeneity at the level of cancer, stromal and immune cell interactions that defy systematic classification of PDA due to small sample sizes. To circumvent this issue and to better characterize heterogeneity along with cellular phenotypes, we successfully applied signatures from our pCAFassigner and heterocellular subtypes (representing different cell types/phenotypes of colorectal cancer) along with CIBERSORT to clinical PDA (~757) samples. Interestingly, this analysis identified a subset of our published quasi-mesenchymal (QM)-PDA subtype samples with either increased stem/stroma or inflammatory (not immunogenic subtype) heterocellular characteristics. The stem-like subtype showed variable enrichment of intrinsic CAF (pCAFassigner) subtype characteristics with distinct tumor promoting capabilities (as assessed using CAF:cancer co-culture system) and immune cell interactions. Hence, QM-PDA subtype samples with stem-like characteristics were further split into four stroma-enriched sub-subtypes with significant (p&amp;lt;0.05; log-rank test) differences in patient prognosis. In contrast, the other stem-like QM-PDA subtype patients were enriched for adaptive immunity and may benefit from B cell therapy. On the other hand, inflammatory-enriched QM-PDA subtype samples contained increased macrophages and highly invasive CAFs leading to poorest patient prognosis. These inflammatory subtype patients may respond well to immune therapies targeting macrophages. While all PDA samples are considered to have uniformly high stroma, our study demonstrates that the stromal content is highly variable depending on the sub-subtypes leading to potential personalized therapy responses targeting immune and/or stromal compartments in this devastating cancer type. Note: This abstract was not presented at the meeting. Citation Format: Pawan Poudel, Cindy Neuzillet, Hemant Kocher, Anguraj Sadanandam. Reclassification of pancreatic adenocarcinoma with distinct fibroblast and immune characteristics and therapeutic targets [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3094.
Portal venous thrombosis and liver transplant: incidence and evolution in the 1st year after transplant
Authors: Eva Julissa Ortega Suazo, Patricia Abellan Alfocea, María Dolores Espinosa Aguilar, Ana Gila Medina, Mercedes Angeles Gonzalez Sanchez, Flor Nogueras López, Eduardo Redondo, Maria Angeles Lopez Garrido
Journal: Journal of Hepatology (2020)
Quick Fixes for Quicksilver
Authors: W. Conard Holton
Journal: Environmental Health Perspectives (1998)

Mercury pollution is a persistent and increasing problem in the environment. Along with some natural sources of the metal, major man-made sources of mercury pollution include incinerators, fossil fuel plants, and municipal sewage systems. The EPA estimated that in 1989, approximately 643,000 kg of mercury was discarded as municipal solid waste, with 84% of it landfilled.
Polyunsaturated fatty acids and colchicine in multiple sclerosis.
Authors: A Nathian
Journal: BMJ (1979)

does not form calcium complexes in bone- forming tissue.Brucellosis, also mentioned by Brock and Roach, is fortunately uncommon within the British Isles3; but co-trimoxazole,4 either alone or in combination with streptomycin, offers highly effective chemotherapy.In this vulnerable group of patients, if a tetracycline is thought to be obligatory, doxycycline would be the least toxic of the group, as its affinity for calcium has been shown to be less than that of the other tetra- cyclines.5However, even this agent is potentially dangerous in childhood and during pregnancy, and must be avoided if at all possible.
THE BROWN-SEQUARD METHOD OF TESTICULAR EXTRACT THERAPY.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Protein Kinase C Family for Neuronal Signaling
Authors: C Tanaka
Journal: Annual Review of Neuroscience (1994)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Booknote
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Titles
Authors: Lindsay Nelson, Abpp-Cn Harvey, S Levin, Michael Mccrea, Sureyya Dikmen
Journal: JAMA Neurology (2020)

tional limitations reported on the GOSE in the present study 1 contradicts the assertion that the instrument lacks sensitivity.Moreover, we discourage assumptions that predominantly self-reported symptoms or functional limitations are invalid.Although these data cannot inform an understanding of response bias, prior work suggests that outcomes assessed in a research context do not necessarily show the patterns of response bias that are often found in medicolegal settings. 3 Other criticisms pertained to our defining the criteria of mTBI as an admission Glasgow Coma Scale (GCS) score of 13 to 15 and the decision to include patients with acute intracranial findings on computed tomography (CT) scans.We defined mTBI based on GCS scores because, in our experience, this is commonly done in the medical and research community.We agree that the population with GCS scores of 13 to 15 exhibits diverse TBI severity and other characteristics associated with outcomes, and thus it is important to recognize that one cannot, from these data alone, determine the cause(s) of persistent functional limitations.Nevertheless, the finding of diverse, sometimes poor outcomes in this population underscores the importance of moving beyond crude historic systems of TBI stratification and developing more refined approaches for classifying and treating patients.Finally, recognizing the importance of CT findings, all analyses were presented on the aggregate sample and stratified by CT findings.We hope that the availability of large, richly characterized cohorts of patients with TBI, such as the TRACK-TBI sample, places us at the cusp of reconceptualizing mTBI, which is critical for advancing precision medicine clinical care for the large "mild" TBI population.
Cancer of the urogenital tract: bladder cancer. The accuracy of clinical vs. surgical staging
Authors: R. Baker
Journal: JAMA (1968)

Treatment of bladder cancer presents a serious and often perplexing problem to the urologist. From five different modes of surgical treatment and a minimum of three techniques of radiation therapy, he must select one which is suitable for the general condition of the patient having a bladder cancer of specific stage of infiltration, specific cell type, degree of cellular differentiation, size, and location within the bladder; and he must consider whether there are single or multiple lesions. Some of these factors have greater weight than others in determining the type of treatment and curability. The stage of infiltration of the bladder wall with a malignancy is, without doubt, the single most important factor. Many characteristics associated with infiltration and spread of tumor cells within the bladder have been observed and reported. Certain of these will be discussed subsequently as they apply to clinical, surgical, and histologic staging. Data concerning staging
Landmark perspective: Smoking and lung cancer. A milestone in awareness
Authors: J. L. Steinfeld
Journal: JAMA (1985)

DR EVARTS Graham and his colleague, senior medical student Ernest Wynder, published the results of their collaborative epidemiologic studies in the<i>Journal of the American Medical Association</i>about the time of Mr Wynder's graduation as a physician. The article, "Tobacco Smoking as a Possible Etiologic Factor in Bronchiogenic Carcinoma," was a seminal article in 1950 for a number of reasons. It was the largest retrospective study on tobacco smoking conducted up to that time. It incorporated patients from many centers, thus obviating the criticism that a particular group of adults were subject to a unique, unknown exposure in a defined geographic region, thereby confounding the results. It established standards for retrospective studies, which included a successful technique for quantifying the number of cigarettes (plus cigars and pipesful of tobacco) consumed, the number of years of smoking, the age at which smoking began, and the brand of cigarettes smoked (although such
Hospital Bathrooms and Showers: A Continuing Saga of Inadequacy
Authors: Andy Monro, Graham P Mulley
Journal: Journal of the Royal Society of Medicine (2004)

Previous surveys of UK hospitals have highlighted many deficiencies in the standards of hospital inpatient washing and bathing facilities--especially inadequate access for wheelchair users, insufficient bathing equipment, and unsatisfactory cleanliness and privacy. We conducted a qualitative survey in three hospitals in the North of England to see whether these facilities have improved. There have been some improvements, particularly in the provision of bath hoists, adapted taps, alarm call systems, shower seats and wheelchair access to bathrooms. But many basic problems remain-absent locks and signs, inadequate heating, poor standards of privacy, insufficient bath aids, wet floors, and the inappropriate use of bathrooms as store rooms. The overall condition of hospital bathrooms and showers remains unsatisfactory. Too many hospital bathrooms are austere, cold, smelly and poorly maintained.
Chairman's Address
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal