tbuckley/cabot-search huggingface dataset:
Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomised, double-blind, placebo-controlled, phase II regimen-finding study
Authors: P. Rich, B. Sigurgeirsson, D. P. Thaci, J.-P. Ortonne, C. Paul, R.E. Schopf, A. Morita, K. Roseau, E. Harfst, A. Guettner, M. Machacek, C. Papavassilis
Journal: British Journal of Dermatology (2012)

Background Interleukin (IL)-17A has major proinflammatory activity in psoriatic lesional skin. Objectives To assess the efficacy and safety of secukinumab, a fully human IgG1κ monoclonal anti-IL-17A antibody, in moderate-to-severe plaque psoriasis in a phase II regimen-finding study. Methods A total of 404 patients were randomized to subcutaneous placebo (n = 67) or one of three secukinumab 150 mg induction regimens: single (week 0; n = 66), early (weeks 0, 1, 2, 4; n = 133) and monthly (weeks 0, 4, 8; n = 138 patients). The primary outcome was ≥ 75% improvement from baseline Psoriasis Area and Severity Index score (PASI 75) at week 12. PASI 75 responders from active treatment arms at week 12 were rerandomized to either a fixed-interval (secukinumab 150 mg at weeks 12 and 24; n = 65) or a treatment-at-start-of-relapse maintenance regimen (secukinumab 150 mg at visits at which a start of relapse was observed; n = 67). Results At week 12, early and monthly induction regimens resulted in higher PASI 75 response rates vs. placebo (54·5% and 42·0% vs. 1·5%; P < 0·001 for both). Among PASI 75 responders at week 12 entering the maintenance period, PASI 75 and PASI 90 achievement at least once from week 20 to week 28 was superior with the fixed-interval regimen [85% (n = 55) and 58% (n = 38), respectively] vs. the start-of-relapse regimen [67% (n = 45), P = 0·020, and 21% (n = 14), respectively]. Fifteen weeks after last study drug administration, < 10% of patients in the fixed-interval and start-of-relapse groups experienced a start of relapse. No immunogenicity was observed, and no injection-site reactions were reported. Reported cases of neutropenia were mild-to-moderate (≤ grade 2); none was associated with clinically significant adverse events or resulted in study discontinuation. Due to the brief duration of the safety assessment, no firm conclusions can be drawn regarding long-term safety. Conclusions Secukinumab shows efficacy for induction and maintenance treatment of moderate-to-severe plaque psoriasis.
Which Oral Anticoagulant for Atrial Fibrillation?
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Pediatrics (2016)

Much attention has been given to the importance of the intestinal microbiota and the eff ects of early exposure to antibiotics.In this longitudinal cohort study, Korpela and coauthors examine whether the positive metabolic eff ects of breastfeeding are aff ected by antibiotic use.The protective eff ects of breastfeeding against infections were found to be weakened or completely eliminated by early-life antibiotic use.The accompanying editorial by Paolella and Vajro discusses methods to potentially avoid or repair changes to the intestinal microbiota in breastfed children who need antibiotics.
Cardiovascular Research, London
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Severe Relapsing-Remitting Multiple Sclerosis with High-Dose Immunosuppressive Therapy and Autologous Hematopoietic Cell Transplantation: 2-Year Follow-up Results of the HALT MS Clinical Trial (Immune Tolerance Network: ITN033AI)
Authors: Richard A. Nash, George J. Hutton, Michael K Racke, Uday R. Popat, Steven M. Devine, George E. Georges, Linda M. Griffith, Paolo A Muraro, Harry Openshaw, Peter H. Sayre, Olaf Stuve, Douglas L Arnold, Meagan Spychala, Noha Lim, Sachin Malhotra, Deborah Phippard, Annette Wundes, George H Kraft, James D Bowen
Journal: Blood (2012)
OBSTETRIC CASES
Authors: S. D. Lees
Journal: BMJ (1855)

AJOURNAL.91$ am bonee The wound w i had ben.nLtdejrevous da, whaerthe bons projeceSd, mwth mind otb the an- terior flap, and its edges wete sloughy.The patient was much prostrated after the operation, and there appeared some danger of his sinking; but he soon raied, and in a few hours was at least as well as before the opeation.The stump was dressed with sutures, etc., in the ordinary way, five or six hours after the operation; two or three more small arteries required ligature.From this time he rapidly recovered.In two or three
Psychiatric aspects of normal pressure hydrocephalus
Authors: E. Rice
Journal: JAMA (1973)

Five patients had normal pressure hydrocephalus (NPH) within the context of a psychiatric dimension. The incidence of NPH is highest in the older age group. Psychiatric sequelae can be the predominant, as well as initial, clinical manifestation of this syndrome. Normal pressure hydrocephalus is an organic brain syndrome that is potentially reversible by a neurosurgical shunting procedure. The mental status of the patient and the necessity for the inclusion of NPH in the differential diagnosis are important.
The Retrospect of Medicine.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cosmetic outcome 1, 2, 3, and 4 years after intraoperative radiotherapy or external beam radiotherapy for early breast cancer: An objective assessment of patients from a randomized controlled trial.
Authors: M. R. Keshtgar, N. R. Williams, T. Corica, C. Saunders, D. J. Joseph, M. Bulsara
Journal: Journal of Clinical Oncology (2011)

1072 Background: The randomised controlled TARGIT Trial was designed to determine non-inferiority between the novel technique of TARGIT [intra-operative radiotherapy with Intrabeam (Carl Zeiss, Germany)] and conventional external beam radiotherapy (EBRT) in women with early breast cancer. The main outcome objective is risk of local relapse within the treated breast. We report here data from a sub-protocol assessing cosmesis in 114 women over 50 years old participating in the TARGIT Trial from one centre (Perth, Australia). Methods: Frontal view digital photographs from were assessed, blind to treatment, using specialist software (BCCT.core 2.0, INESC Porto, Portugal) which produces an objective composite score based on symmetry, colour and scar. Data on patient and tumour characteristics were obtained from hospital notes. Statistical analysis was by generalised estimating equations (GEE) on all data, and logistic regression analysis at year 1 only. Results: Photographs were taken at baseline (before surgery) and one, two, three and four years after initial breast conserving surgery; none of the 114 patients had subsequent breast surgery. Median age at randomisation was 62 years (IQR 56 to 68). The composite scores were dichotomised into Excellent and Good (EG), and Fair and Poor (FP). There was a non-significant 45% increase in the odds of having an outcome of EG for patients in the TARGIT group relative to the EBRT group (OR=1.45, 95%CI 0.78 – 2.69, p=0.245) after adjusting for tumour size. The results were similar when adjusted for tumour grade and age of the patient. For year 1 there was a statistically significant 2.35 fold increase in the odds of having an outcome of EG for patients in the TARGIT group relative to the EBRT group (OR=2.35, 95%CI 1.02 – 5.45, p=0.047) after adjusting for age of the patient, tumour size and grade. Conclusions: These results confirm a significantly better cosmetic outcome with TARGIT compared to EBRT in the first year after surgery.
Frozen Sections
Authors: John R. Mawk
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In his recent article, Dr Kindschi provided caveats for surgeons requesting frozen sections. He has failed to address three important surgical concerns, however. First, the availability of a reasonably certain frozen section diagnosis may alter judgments made in the immediate perioperative period. For instance, a patient believed to harbor a benign neoplastic or inflammatory disease preoperatively, who is known by frozen section to instead have a malignant brain neoplasm, might be treated less aggressively in the post-operative period if unexpected medical problems arise. This situation unfortunately is a recurring problem for neurosurgeons and, I am sure, for many of our other surgical colleagues as well. The second problem that Dr Kindschi has not addressed relates to training of pathology residents to interpret frozen sections. Unless the frozen section is a reasonably routine event in the histopathology laboratory, then preparation and interpretation of the frozen section will be
A means of assessing maximal oxygen intake. Correlation between field and treadmill testing
Authors: K. H. Cooper
Journal: JAMA (1968)

One hundred and fifteen US Air Force male officers and airmen were evaluated on a 12-minute field performance test and on a treadmill maximal-oxygen-consumption test. The correlation of the field-test data with the laboratory-determined oxygen-consumption data was 0.897. The significance of this relationship makes it possible to estimate with considerable accuracy the maximal oxygen consumption from only the results of the 12-minute performance test. This test is readily adaptable to large groups, requires minimum equipment, and appears to be a better indicator of cardiovascular fitness than the more commonly accepted 600-yard run. Because of the high correlation with maximal oxygen consumption, it can be assumed that the 12-minute field performance test is an objective measure of physical fitness reflecting the cardiovascular status of an individual.
Performance Evaluation Programs for Determining HIV-1 Viral Loads, Testing for HIV p24 Antigen, and Identifying Mycobacterium tuberculosis Using Nucleic Acid Amplification Tests
Journal: JAMA (1997)

CDC's Division of Laboratory Systems, Public Health Practice Program Office, is implementing three new laboratory performance evaluation (PE) programs. The first assesses the performance of laboratories that perform tests to determine the viral RNA copy number (viral load) in the blood of persons infected with human immunodeficiency virus type 1 (HIV-1); the second assesses the performance of laboratories that perform HIV p24 antigen (Ag) testing; and the third assesses the performance of laboratories that perform nucleic acid amplification (NAA) tests for Mycobacterium tuberculosis.
The Mechanism of Nervous Action: Electrical Studies of the Neurone
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The increasing incidence of Ampicillin-resistant Haemophilus influenzae. A cause of otitis media
Authors: R. Schwartz
Journal: JAMA (1978)

Middle ear exudate was obtained by myringotomy or aspiration from 625 suburban children, aged 1 month to 12 years, who had acute otitis media; bacterial pathogens were isolated from 71%. Haemophilus species were isolated from 212 (29%), and Streptococcus pneumoniae from 205 (28%). From 1975 to August 1977, the number of Haemophilus isolates found to be resistant to ampicillin has appreciably increased. Currently, 8% of all cases of acute otitis media in the Washington, DC, area are due to H influenzae resistant to ampicillin. Thirty-one of 35 patients with resistant H influenzae otitis were treated with an erythromycin/sulfisoxazole combination with an impressive clinical response. Twenty-six of these 31 cases had failed to have H influenzae eradicated by an average of ten days of oral ampicillin in recommended doses.
Misspelling of Author’s Surname
Journal: JAMA Neurology (2017)

Rabe E. Alhurani, MBBS; Maria Vassilaki, MD, PhD; Jeremiah A. Aakre, MPH; Michelle M. Mielke, PhD; Walter K. Kremers, PhD; Mary M. Machulda, PhD; Yonas E. Geda, MD, MSc; David S. Knopman, MD; Ronald C. Petersen, MD, PhD; Rosebud O. Roberts, MB, ChB
BACTERIOPHAGE THERAPY
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polio
Authors: Bishara J. Freij
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Second primary malignancies in multiple myeloma: an overview and IMWG consensus
Authors: P. Musto, K.C. Anderson, M. Attal, P.G. Richardson, A. Badros, J. Hou, R. Comenzo, J. Du, B.G.M. Durie, J. San Miguel, H. Einsele, W.M. Chen, L. Garderet, G. Pietrantuono, J. Hillengass, R.A. Kyle, P. Moreau, J.J. Lahuerta, O. Landgren, H. Ludwig, A. Larocca, A. Mahindra, M. Cavo, A. Mazumder, P.L. McCarthy, A. Nouel, S.V. Rajkumar, A. Reiman, E. Riva, O. Sezer, E. Terpos, I. Turesson, S. Usmani, B.M. Weiss, A. Palumbo
Journal: Annals of Oncology (2017)
Masthead: (Adv. Healthcare Mater. 4/2017)
Journal: Advanced Healthcare Materials (2017)

Citizenship: Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused on sharing our content with those in need, enhancing community philanthropy, reducing our carbon impact, creating global guidelines and best practices for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our efforts.
Treatment of invasive bladder cancer by cisplatin and radiation in patients unsuited for surgery
Authors: W. U. Shipley
Journal: JAMA (1987)

Seventy patients with muscle-invading bladder carcinoma (clinical stages T2 to T4) who were<i>not</i>candidates for cystectomy were treated with combined cisplatin and full-dose external-beam radiation on a multi-institutional prospective protocol from 1980 through 1985. Thirty-six patients are alive, all but three without evidence of cancer. The complete response rate is 77% in the 62 patients completing planned irradiation and 70% for all patients. Among the complete responders, 73% are currently maintained, and this group has a significantly higher four-year survival than those not having a complete response and those with recurrence of disease—57% vs 11%. The observed high complete response rates in patients in all stages and the high survival rates suggest irradiation plus cisplatin therapy offers an important therapeutic gain over radiation therapy alone for invasive cancer of the bladder. These results encourage further evaluation of combining cisplatin-based, multidrug chemotherapy with irradiation in patients with locally very-advanced bladder tumors who are not suited for surgery. (<i>JAMA</i>1987;258:931-935)
Kendall, Edsall, and Fothergill
Authors: E.J.  H.
Journal: Annals of Internal Medicine (1971)

The Literature of Medicine1 July 1971Kendall, Edsall, and FothergillE.J. H.E.J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-1-145 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRarely do three new major autobiographies or biographies in medical history come to readers in the space of 6 months. Such a rare event is celebrated in this review.The shortest of these is the truncated autobiography*of Edward C. Kendall, Nobelist for Physiology or Medicine in 1950 and isolator of thyroxine and adrenal cortical steroids. His account begins with his childhood, runs through his education at Columbia and his early disappointments in New York, gains power as he relates his pioneering in endocrine biochemistry at the Mayo Clinic, and comes to its climax and end at the Nobel Prize...References1. FOTHERGILL J: To Lieutenant-Colonel Gilbert Ironside, December 22, 1774, in Chain of Friendship: Selected Letters of Dr. John Fothergill of London, 1735-1780. With Introduction and Notes by CORNER BC, BOOTH CC. Cambridge, The Belknap Press of Harvard University Press, 1971, p. 432 Google Scholar2. FOTHERGILL J: To Henry Zouch, October 8, 1779, in Ref. 1, p. 492 Google Scholar3. FOTHERGILL J: To Benjamin Franklin, Passy, France, October 25, 1780, in Ref. 1, p. 497 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *KENDALL EC: Cortisone: Memoirs of a Hormone Hunter. 175 pages. Charles Scribner's Sons, New York, 1971. Price, $7.95. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1971Volume 75, Issue 1Page: 145-147KeywordsBiochemistryHormonesSteroidsThyroxine ePublished: 1 December 2008 Issue Published: 1 July 1971 PDF downloadLoading ...