tbuckley/cabot-search huggingface dataset:
I am about to take up a training number as a specialist registrar in general surgery. I am interested in a career in breast surgery and would like to be able to do oncoplastic procedures. I have no plastics experience to date. Is it possible to become an oncoplastic breast surgeon through a general surgical route, with perhaps a clinical fellowship in oncoplastics?
Authors: Abhilash Jain
Journal: BMJ (2006)

Epidemiological research to identify subpopulations with enhanced susceptibility to air pollution is still at an early stage. From the available studies, there is evidence that both “endogenous” and “exogenous” factors contribute to individual susceptibility. Females and the elderly are at an increased risk of pollution-related diseases. Moreover, some chronic clinical conditions seem to be good candidates for identifying the “frail” populations: chronic obstructive pulmonary disease including asthma, coronary heart diseases, congestive heart failure, and heart rhythm disorders. It seems clear that epidemiological research on susceptibility in the future should investigate the underlying biological and physiological mechanisms, in addition to the environmental and toxicological effects.
A New Printer for JAMA
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for candidate hepatic growth factors by selective portal infusion after canine Eck's fistula
Authors: A Francavilla
Journal: Hepatology (1991)

Completely diverting portacaval shunt (Eck's fistula) in dogs causes hepatocyte atrophy, disruption of hepatocyte organelles, fatty infiltration and lowgrade hyperplasia. The effect of hepatic growth regulatory substances on these changes was assessed by constantly infusing test substances for four postoperative days after Eck's fistula into the detached left portal vein above the shunt. The directly infused left lobes were compared histopathologically with the untreated right lobes. In what has been called an hepatotrophic effect, stimulatory substances prevented the atrophy and increased hepatocyte mitoses. Of the hormones tested, only insulin was strongly hepatotrophic; T3 had a minor effect, and glucagon, prolactin, angiotensin II, vasopressin, norepinephrine and estradiol were inert. Insulin-like growth factor, hepatic stimulatory substance, transforming growth factor–α and hepatocyte growth factor (also known as hematopoietin A) were powerfully hepatotrophic, but epidermal growth factor had a barely discernible effect. Transforming growth factor–β was inhibitory, but tamoxifen, interleukin-1 and interleukin-2 had no effect. The hepatotrophic action of insulin was not altered when the insulin infusate was mixed with transforming growth factor–β or tamoxifen. These experiments show the importance of in vivo in addition to in vitro testing of putative growth control factors. They illustrate how Eck's fistula model can be used to screen for such substances and possibly to help delineate their mechanisms of action. (HEPATOLOGY 1991;14:665–670.)
Low back pain
Authors: S. Skyte
Journal: BMJ (1995)

Changes to obituaries are insensitive EDITOR,-I deplore the BMJs decision to tamper with the obituary pages.'It strikes me as mean minded, discourteous, and insensitive to the bereaved.The BMA isn't a trade union, a scientific organisation, or an environmental pressure group.It should be a sort of doctors' common room where we can gossip, moan about managers and patients, and generally encourage one another.It now seems unable either to support its members while they are alive or to respect them when they are dead.I'm sorry that this letter is 131 words long, isn't evidence based, and hasn't been sent by email.Nevertheless, I hope that it will be published as it contains no cliches, Latin words, or imperial measures; I've been a member of the BMA for 20 years (C4608 at current rates); and I enclose a stamped addressed envelope (1 9p).
Life Begins
Authors: M. Therese Southgate
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hiatus Hernia
Authors: Walter E. Brown
Journal: JAMA (1963)

<h3>To the Editor:</h3> —The synopsis-abstract which precedes the paper entitled, "Hiatus Hernia with Esophagitis and Acute Hemorrhage," by Lt Col Hood and Lt Col McChesney, in the Oct 20 issue ofThe Journal(<b>182</b>:243), is so at variance with the findings in the article itself, that I believe a correction should be made. The statement is made in the synopsis-abstract that: "X-ray studies were not adequate and were sometimes misleading." However, exactly the opposite is brought out in the article and in the summary by the authors at the end of the paper.
From the National Institutes of Health
Authors: William Raub
Journal: JAMA (1989)

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Foreword
Authors: Peter Siersema
Journal: Endoscopy (2015)

Although 2015 was not a year of groundbreaking new endoscopic developments, we saw again an increasing number of manuscripts submitted to Endoscopy. The year 2015 can probably best be summed up by the conclusion that the fundamentals of endoscopy have been further strengthened. Endoscopy was right at the center of this, with articles on quality improvement in endoscopy, on teaching and training the next generation of endoscopists and on some new technologies, but particularly on new indications for established techniques and on long-term follow-up results.
Bismuth preparations for diarrhea
Authors: Markus Kruesi
Journal: JAMA (1980)

<h3>To the Editor.—</h3> I read the article by DuPont et al (243:237, 1980), describing their experience with the use of subsalicylate bismuth as prophylaxis for traveler's diarrhea. The authors suggest that subsalicylate is the active moiety. Information from Australia may suggest otherwise and add impetus to the authors urging characterization of the dynamics of bismuth absorption. Australian colostomy patients have frequently used bismuth subgallate to make bowel action more predictable and to control fecal odors effectively,<sup>1</sup>actions similar to those seen with the salicylate bismuth. A more important consideration for persons planning to take bismuth for a prolonged period is the risk of neuropsychiatric toxic effects that may be seen with long-term bismuth ingestion. Case reports<sup>1,2</sup>note difficulty in recall, upper and lower limb ataxia, tremor, insomnia, visual disturbances, possible hearing loss, and acute brain syndrome, which has included both auditory and visual hallucinations. In all of these
Simultaneous onset of primary cutaneous B-cell lymphoma and human herpesvirus 8-associated Kaposi's sarcoma
Authors: E. BERTI, A.V MARZANO, I. DECLEVA, G. BESTETTI, M. PIZZUTO, L. POIREL, M. CAPRA, C. PARRAVICINI, M. CORBELLINO
Journal: British Journal of Dermatology (1997)
Officials of the Association
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hunger strikes
Authors: G. J Annas
Journal: BMJ (1995)

<h3>SUMMARY</h3> Planning and execution of voluntary movement depend on the contribution of distinct classes of neurons in primary motor and premotor areas. However, the specific functional role of GABAergic cells remains only partly understood. Here, electrophysiological and computational analyses are employed to compare directly the response properties of putative pyramidal (PNs) and fast-spiking, GABAergic neurons (FSNs) during licking and forelimb retraction in mice. Recordings from anterolateral motor cortex and rostral forelimb area, reveal that FSNs fire earlier and for a longer duration than PNs, with the exception of a subset of early-modulated PNs in deep layers. Computational analysis reveals that FSNs carry vastly more information than PNs about the onset of movement. While PNs differently modulate their discharge during distinct motor acts, most FSNs respond with a stereotyped increase in firing rate. Accordingly, the informational redundancy was greater among FSNs than PNs. These data suggest that a global rise of inhibition contributes to early action planning.
Correction
Authors: Makoto Miyara, Zahir Amoura, Christophe Parizot, Cécile Badoual, Karim Dorgham, Salim Trad, Marianne Kambouchner, Dominique Valeyre, Catherine Chapelon-Abric, Patrice Debré, Jean-Charles Piette, Guy Gorochov
Journal: The Journal of Experimental Medicine (2006)
Enzyme inhibitory autoantibodies to pyruvate dehydrogenase complex in primary biliary cirrhosis: Applications of a semiautomated assay
Authors: K Teoh
Journal: Hepatology (1994)

Sera from patients with primary biliary cirrhosis inhibit the activity of the mitochondrial pyruvate dehydrogenase complex. We utilized this effect to develop a simple, miniaturized, semiautomated spectrophotometric assay as a diagnostic aid. The sera studied were from 71 patients with primary biliary cirrhosis and 62 other subjects. The assays included enzyme inhibition, immunofluorescence on HEp-2 cells, enzyme-linked immunosorbent assay using recombinant pyruvate dehydrogenase complex-E2 and immunoblotting on bovine heart mitochondria. With the 71 primary biliary cirrhosis sera, on which M2 antibody was detected by immunofluorescence in 64 (90%), antibodies against pyruvate dehydrogenase complex were detected in 53 (83%) by means of enzyme inhibition, in 57 (89%) by means of enzyme-linked immunosorbent assay and in 60 (94%) by means of immunoblotting. Of the 64 sera positive by immunofluorescence, 60 reacted with pyruvate dehydrogenase complex-E2 on immunoblotting, and the miniaturized enzyme inhibition assay was positive in 53 of these. The enzyme inhibition assay and enzyme-linked immunosorbent assay were calibrated to give a specificity of 100%. At this level, the sensitivities for detection of pyruvate dehydrogenase complex antibody were 83% and 87%, respectively. We found no significant changes in levels of reactivity with the enzyme inhibition assay or enzyme-linked immunosorbent assay according to disease stage. Treatment with cyclosporine was accompanied by a significant decrease in levels of antibody to pyruvate dehydrogenase complex-E2 that matched improved indexes of biochemical liver function. The semiautomated enzyme inhibition assay as described provides an additional diagnostic procedure in pyruvate dehydrogenase complex; this type of assay involving specific enzyme inhibition could also be generically applied to any autoantibody antigen system. (Hepatology 1994;20:1220–1224).
<i>Die Hirnlaehmungen der Kinder</i>. Von B. Sachs. Volkmanns Sammlung Klinischer Vortraegs. Nr. 46. 47. Leipzig: Brsitkopf und Haertel, 1892. [The Cerebral Palsies of Children. By B. Sachs.]
Journal: American Journal of Psychiatry (1892)
Special Susceptibility of the Child to Certain Radiation-Induced Cancers
Authors: Robert W. Miller
Journal: Environmental Health Perspectives (1995)

The carcinogenic effects of exposure to ionizing radiation vary markedly with age, as revealed by studies of Japanese atomic bomb survivors and of Marshall Islanders exposed to fallout from U.S. nuclear weapons tests in the South Pacific in 1954.An increase in cancers of adulthood after intrauterine exposure, as reported in 1988, has not been sustained.After childhood exposure, increases in leukemia, breast cancer, and thyroid cancer are well established.The carcinogenic effects of radiation on the young have been reported after intrauterine exposures and after exposures during childhood.Cancers with short latent periods such as leukemia occur during childhood, but those with long latent periods such as breast cancer occur in adulthood.
Phase II Study of Combination of hyperCVAD with Dasatinib in Frontline Therapy of Patients with Philadelphia Chromosome (Ph) Positive Acute Lymphoblastic Leukemia (ALL)
Authors: Farhad Ravandi, Deborah Thomas, Hagop Kantarjian, Stefan Faderl, Charles Koller, Samuel Dara, Rebecca Garris, Partow Kebriaei, Gautam Borthakur, William Wierda, Jan Burger, Jorge Cortes, Susan O’Brien
Journal: Blood (2008)
Incorrect Spelling
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuregulin (NRG) expression modulates clinical response to trastuzumab in patients with metastatic breast cancer (MBC)
Authors: E. De Alava, M. Abad, C. A. Rodriguez, J. C. Montero, E. Serrano, A. Ocana, A. Torres, M. Ruiz, J. J. Cruz, A. Pandiella
Journal: Journal of Clinical Oncology (2006)

10069 Background: ErbB2 overexpression is the major determinant of response to trastuzumab (Herceptin, H). Recently, some authors have reported the potential role of the expression of NRG on ErbB2 activation in breast cancer cells, and its consequences in response to treatment with H. In the present study we analyze the relationship between response to H and expression of ErbB2 and NRG in patients (pt) with MBC. Methods: Data and frozen tissue samples from 30 consecutive pt with MBC and positive ErbB2 at diagnosis [Immunohistochemistry (IHC)] were collected. All pt were treated with an Herceptin-based regimen. Central Pathologic review of ErbB2 expression was performed in all samples (Herceptest and FISH). NRG expression was studied by IHC on paraffin embedded material and by Western blotting on frozen tissue using an antibody raised against the intracellular domain of NRG. NRG expression by IHC was evaluated using a semiquantitative scoring system that assesses both extension and intensity of cytoplasmic staining. Correlation between ErbB2 and NRG expression and its influence in response to H was analyzed. Characteristics of pt: Median Age: 54; Median mts sites: 2; Treatment: H alone:1 pt; H+Taxol:15 pt; H+Taxol+Carbo: 4 pt; H+Taxol+Lip.Doxorub:2 pt, H+Vinorelbine:7 pt; H+CDDP:1 pt. Results: ORR: 76% (CR:23%, PR:53%). Median TTP: 7.8 m. After central Pathologic review, a total of 20 tumors showed ErbB2 amplification by FISH and 19 of them were Herceptest 3+. A positive correlation was observed between ErbB2 amplification and NRG expression. All complete responses (n=7) were seen in pt with ErbB2 amplification. Interestingly, in the group of tumors without ErbB2 amplification (n=10), 7 had high NRG expression levels, as assessed by IHC. Six out of these 7 tumors having high levels of NRG expression, exhibited partial responses. NRG expression, in turn, did not have impact on response among ErbB2 amplified tumors. Conclusions: These preliminary results suggest that responses to H regimens in pt with MBC can be seen in pt lacking ErbB2 amplification in presence of high levels of expression of transmembrane ligand NRG. This suggests that the group of pt that may benefit from treatment with H could be broader than currently established. A confirmatory study is ongoing in a larger series. No significant financial relationships to disclose.
Hear! Hear! An Informal Guide to Public Speaking After Dinner; on the Lecture Platform; over the Radio
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anabolic steroid use in adolescence
Authors: W. V. Moore
Journal: JAMA (1988)

The study of Buckley et al<sup>1</sup>in this issue ofTHE JOURNALis informative in describing the extent of usage of anabolic steroids (AS) in a segment of the population in which usage was suspected but data were lacking. Since many of the users among high school seniors might be described as habitual, the data may also be important in describing AS misuse in the adult population, the prevalence of which is not known and may be virtually impossible to ascertain. It may be reasonable to anticipate that adolescents will continue habitual use as adults; however, since the primary motivation among high school users was to increase strength among football athletes, the prevalence may decrease after high school, when participation in football declines. The current study achieved a reasonable response rate (approximately 50%). As with other surveys, the prevalence might be larger or smaller (this is a moot point)
Archives of Neurology, Chicago
Journal: JAMA (1970)

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