tbuckley/cabot-search huggingface dataset:
Sensorineural deafness.
Authors: E Douek
Journal: BMJ (1990)

Thus chromosomal changes may be useful in the early detection of the risk of leukaemia and for selecting cytotoxic combinations with a low risk.The studies of Kaldor et al emphasise the importance of the long term consequences of the treatment of cancer.In ovarian carcinoma the challenge is to develop more effective treatment; the induction of second malignancy is of subsidiary importance, at least in advanced disease.But now that Hodgkin's disease is cured in about 70% of cases the problem of second malignancy and other long term consequences is assuming much greater importance.2'The challenge here is to modify treatment to reduce the risk of leukaemia and other complications while maintaining effectiveness; for instance, less leukaemogenic combinations already developed also reduce the incidence of sterility in men and are as effective as the conventional four drug regimen mechlorethamine, procarbazine, vincristine, and prednisone-MOPP.Other strategies, such as avoiding splenectomy, may need to be considered.As a research tool chromosomal changes may prove to be helpful in the early selection of chemotherapy regimens least likely to induce malignancy.
Viewing the Journal of the National Cancer Institute
Authors: M. F. Stanton
Journal: CA A Cancer Journal for Clinicians (1970)

the Rauscher murine leukemia virus (RMLV) to BALB/c mice by exposure of RMLV as an aerosol.Mice in contact with aerosol-exposed cagemates also developed leukemia, which indicated hori zontal transmission of the virus.The leukemic response of the exposed mice
Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation
Authors: Odette Viñas, Ramón Bataller, Pau Sancho-Bru, Pere Ginès, Cristina Berenguer, Carlos Enrich, Josep M. Nicolás, Guadalupe Ercilla, Teresa Gallart, Jordi Vives, Vicente Arroyo, Juan Rodés
Journal: Hepatology (2003)

Following cell activation, hepatic stellate cells (HSCs) acquire proinflammatory and profibrogenic properties. We investigated whether activated HSCs also display immune properties. Here we show that cultured human HSCs express membrane proteins involved in antigen presentation, including members of the HLA family (HLA–I and HLA–II), lipid–presenting molecules (CD1b and CD1c), and factors involved in T–cell activation (CD40 and CD80). Exposure of HSCs to proinflammatory cytokines markedly up–regulates these molecules. Importantly, cells freshly isolated from human cirrhotic livers ( in vivo activated HSCs) highly express HLA–II and CD40, suggesting that HSCs can act as antigen–presenting cells (APCs) in human fibrogenesis. We also explored whether human HSCs can efficiently process exogenous antigens. Activated HSCs internalize low– and high–molecular–weight dextran and transferrin, indicating that they can perform fluid–phase and receptor–mediated endocytosis. Moreover, HSCs can perform phagocytosis of macromolecules because they internalize latex particles as well as bacteria. Interestingly, both culture–activated and in vivo activated HSCs express high levels of CD68, a protein involved in antigen trafficking. Finally, we studied whether HSCs modulate T–lymphocyte proliferation. In basal conditions, coculture of irradiated HSCs barely induces allogeneic T–lymphocyte proliferation. However, cytokine–stimulated HSCs stimulate the allogeneic T–lymphocyte response in an HLA–II—dependent manner. In conclusion, human activated HSCs express molecules for antigen presentation, internalize macromolecules, and modulate T–lymphocyte proliferation. These results suggest that HSCs may play a role in the immune function of the liver. (Hepatology 2003;38:919-929).
CURRENT LITERATURE. INFLAMMATIONS, ETC
Journal: British Journal of Dermatology (1933)

British Journal of DermatologyVolume 45, Issue 5 p. 210-217 CURRENT LITERATURE. INFLAMMATIONS, ETC First published: May 1933 https://doi.org/10.1111/j.1365-2133.1933.tb12422.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume45, Issue5May 1933Pages 210-217 RelatedInformation
An Outline of Endocrinology.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Torsion of the spermatic cord in utero
Authors: J. Y. Gillenwater
Journal: JAMA (1966)

TORSION of the spermatic cord and infarction of the testis in utero is an uncommon condition, and the number of reported cases is small enough to make additional cases of interest. A recent review of the literature by Peterson<sup>1</sup>revealed only 56 cases, 22 of which were noted at birth. The first case reported in this country was that of Campbell<sup>2</sup>in 1948. The incidence is certainly greater than is recognized or reported. Many cases may be mistaken for hematoma due to trauma incurred during the delivery and are not investigated further. Some of the many cases of atrophic testis of the adult may be the result of infarction of the testis in the newborn. Birth trauma may also be a cause of hemorrhage in the testis. The frequent occurrence of intratesticular hemorrhage during birth led Halpert<sup>3</sup>to make gross and microscopic examination of the testes of
Hypoglycemia
Authors: Philip E Cryer, Joseph N Fisher, Harry Shamoon
Journal: Diabetes Care (1994)

Iatrogenic hypoglycemia causes recurrent physical and recurrent or even persistent psychosocial morbidity, and some mortality, in patients with insulindependent diabetes mellitus (IDDM), and in some patients with non-insulin-dependent diabetes mellitus (NIDDM) (1,2). There is now compelling evidence, from the Diabetes Control and Complications Trial (DCCT), that metabolic control delays the development and progression of retinopathy, nephropathy and neuropathy in IDDM, albeit at the expense of an increased frequency of treatment-induced hypoglycemia (3). These findings will almost assuredly provide further impetus to patients and health care providers to attempt to maintain plasma glucose levels as close to the nondiabetic range as possible. If so, hypoglycemia will become an even more common problem for patients with diabetes in the near future.
Emergency Management of Complications of Acute Coronary Occlusion
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician-Patient Communication&lt;subtitle&gt;The Relationship With Malpractice Claims Among Primary Care Physicians and Surgeons&lt;/subtitle&gt;
Authors: Wendy Levinson
Journal: JAMA (1997)

<h3>Objective.</h3> —To identify specific communication behaviors associated with malpractice history in primary care physicians and surgeons. <h3>Design.</h3> —Comparison of communication behaviors of "claims" vs "no-claims" physicians using audiotapes of 10 routine office visits per physician. <h3>Settings.</h3> —One hundred twenty-four physician offices in Oregon and Colorado. <h3>Participants.</h3> —Fifty-nine primary care physicians (general internists and family practitioners) and 65 general and orthopedic surgeons and their patients. Physicians were classified into no-claims or claims (≥2 lifetime claims) groups based on insurance company records and were stratified by years in practice and specialty. <h3>Main Outcome Measures.</h3> —Audiotape analysis using the Roter Interaction Analysis System. <h3>Results.</h3> —Significant differences in communication behaviors of no-claims and claims physicians were identified in primary care physicians but not in surgeons. Compared with claims primary care physicians, no-claims primary care physicians used more statements of orientation (educating patients about what to expect and the flow of a visit), laughed and used humor more, and tended to use more facilitation (soliciting patients' opinions, checking understanding, and encouraging patients to talk). No-claims primary care physicians spent longer in routine visits than claims primary care physicians (mean, 18.3 vs 15.0 minutes), and the length of the visit had an independent effect in predicting claims status. The multivariable model for primary care improved the prediction of claims status by 57% above chance (90% confidence interval, 33%-73%). Multivariable models did not significantly improve prediction of claims status for surgeons. <h3>Conclusions.</h3> —Routine physician-patient communication differs in primary care physicians with vs without prior malpractice claims. In contrast, the study did not find communication behaviors to distinguish between claims vs no-claims surgeons. The study identifies specific and teachable communication behaviors associated with fewer malpractice claims for primary care physicians. Physicians can use these findings as they seek to improve communication and decrease malpractice risk. Malpractice insurers can use this information to guide malpractice risk prevention and education for primary care physicians but should not assume that it is appropriate to teach similar behaviors to other specialty groups.
"ATHLETIC STRENUOSITY"
Authors: Charles C. Wolferth
Journal: JAMA (1925)

<h3>To the Editor:</h3> —That portion of the interesting editorial entitled "Athletic Strenuosity" (The Journal, July 25) dealing with college athletics contains several statements which, in my opinion, should not be permitted to pass unchallenged. I am well aware of the fact that support for these statements is to be found in the literature. If their validity is established, or can be established, they constitute an indictment of college athletics so serious that the forms of competition should be modified at once. The significance of the statement that "oversized boys, tall and overweight," make excellent football material depends on one's definitions of oversized and overweight. Undoubtedly, boys who win a place on a big varsity team are usually, but not always, larger and heavier than the average of their classmates. It seems rather harsh, however, to call these beautifully developed lads oversized and overweight. Most of them carry no excess weight.
Techniques for Assessing Teratogenic Effects: Epidemiology
Authors: J. William Flynt
Journal: Environmental Health Perspectives (1976)

Epidemiologic studies of malformations can aid in the understanding of human teratogenesis. Employing a variety of approaches epidemiology can develop or test hypotheses concerning possible causes or through surveillance provide data useful for a variety of purposes. Drawing heavily upon our experiences at the Center for Disease Control, this paper reviews some concepts and uses of epidemiology in studies of human teratogenesis.
Personal Injuries Caused By Mowers
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endothelial Dysfunction in Coronary Artery Disease
Authors: T. Luscher
Journal: Annual Review of Medicine (1993)

The endothelium is a physical barrier between the blood and vascular smooth muscle, a source of enzymes activating and deactivating cardiovascular hormones and a site of production of relaxing and contracting factors. In addition, the endothelium is a source of growth inhibitors and promoters of vascular smooth muscle cells. Monoaminooxidasc deactivates catecholamines and serotonin. Angiotensin converting enzyme transforms angiotensin I into angiotensin II and breaks down bradykinin into inactive products. Nitric oxide is a potent vasodilator and inhibitor of platelet function that under most circumstances is released together with prostacyclin, which exerts similar effects. Both substances play an important protective role in the coronary circulation in that they cause continuous vasodilation and inhibition of platelet function. In addition, the endothelium is a source of contracting factors such as endothelin-1, thromboxane A2, and endoperoxides. Endothelium-derived growth inhibitors include heparin (sulfates) and transforming growth factor β1, while basic fibroblast growth factors and platelet- derived growth factor and possibly endothelin promote proliferation. Because of its strategic anatomic position, the endothelium is a primary target for injuries and cardiovascular risk factors. In particular, aging, low density lipoproteins, hypertension, diabetes, and ischemia alter endothelium function. In arterial coronary bypass grafts, the release of nitric oxide is more pronounced than in vein grafts. Alterations of endothelial function may contribute to vasospasm, thrombus formation, and vascular proliferation and in turn myocardial ischemia, all commone vents in patients with coronary artery disease.
Entero-vioform
Journal: JAMA (1972)

<h3>To the Editor.—</h3> I think it would be in the interests of readers ofThe Journalto have some formal information regarding the stringent regulations now in force concerning personal medications carried by the traveler. In my position in a company where foreign travel is frequent, I have had discussions with the Department of Justice, Bureau of Narcotics, and the Customs Service as to what precautions should be observed and what regulations are in effect. It appears that any traveler planning to carry medications with him must carry them only for his own use. The medications should be carried in a container from a dispensing pharmacist with appropriate labeling and should have affixed to it a copy of the prescription in addition to the label. This information was given to me by the Customs Bureau in Chicago which further informed me that any medications containing opium, codeine, or mixtures thereof
The Tonsils, Faucial, Lingual and Pharyneal.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ergebnisse der gesamten Medizin.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA Specialty Journals by Subscription
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sodium selenite Se 75. A more specific agent for scanning tumors
Authors: R. R. Cavalieri
Journal: JAMA (1968)

Brain scanning, with any of several radioactive pharmaceutical agents, permits the accurate localization of intracranial lesions. Bone scanning, with radioactive strontium, allows the detection of localized disease of the skeleton. However, none of the agents in current use is specific for tumors. In an attempt to improve the diagnostic accuracy of radioisotope scanning, the usefulness of a new agent, selenite Se 75, has been studied in patients with intracranial disease and in cases of localized lesions of bone. Compared with conventional brain-scanning agents, selenite was equally effective in detecting intracranial tumors and yielded fewer abnormal scans in cases of cerebrovascular disease. In the patients with bone lesions, localization of selenite occurred in tumors and uniformly normal scans were obtained in nonneoplastic disease. Because of its relative specificity for tumors, selenite is of value, particularly when used in combination with conventional scanning agents, in the diagnosis of tumors of brain and bone.
Cloning of variable regions of an antibody that reacts with the soluble fraction of human liver cells and its possible value in chronic liver disease
Authors: H Saito, S Tada, H Ebinuma, K Atsukawa, T Masuda, Y Inagaki, K Tsuchimoto, T Morizane, H Ishii
Journal: Hepatology (1996)

A gene encoding the variable regions of the heavy and light chains of a mouse monoclonal antibody designated H2, which specifically reacts with human liver cells, was cloned into a phagemid vector. The clone of the variable region was designed to be expressed as a separate protein, the structure of which is the same as that of the mouse antibody. The cloned phage protein specifically reacted with anti–idiotypic antibodies produced in rabbits against the original mouse antibody, and this reaction was specifically blocked by the original antibody. The soluble protein, expressed as a fusion protein, was detected as a single 30–kd band on sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS–PAGE) and specifically bound to an anti–H2 idiotypic antibody as determined by Western blot analysis. Sera of patients with various diseases were assayed for antibodies to anti–H2 by sandwich enzyme–linked immunosorbent assay (ELISA). Only sera from patients with chronic liver disease reacted strongly. This binding was specifically blocked by the cloned soluble protein. The nucleotide sequences of the variable regions were determined by the dideoxy chain– termination method, and the sequences were approximately 95% identical to those of other mouse immunoglobulins. These findings suggest that a human antibody with the same idiotype as a mouse monoclonal antibody that reacts with human liver cells, can be detected in patients with chronic liver disease, suggesting that autoimmunity may be partly responsible for these diseases.