tbuckley/cabot-search huggingface dataset:
Surgical Management
Authors: Joseph H. Ogura
Journal: JAMA (1972)

Cancers of the hypopharynx and larynx are unique. These tumors produce symptoms early and the area of tumor involvement can usually be visualized at the initial examination. The dilemma arises because the symptoms produced by cancer are similar to those produced by benign conditions. As a result, patients harboring cancer of the larynx and hypopharynx are frequently treated for benign conditions, thereby delaying the correct diagnosis. In order to detect cancer of the larynx and hypopharynx early, an adequate examination is essential; this should include indirect laryngoscopy. Similar to cancer elsewhere, tumors that are diagnosed early result in an improved cure rate. A high index of suspicion by the initial examining physician will assure early detection and decrease delay before treatment of the tumor begins. <h3>Laryngeal Cancers.—</h3> Hoarseness is the primary symptom of laryngeal cancers. A neoplasm should be suspected in any patient who experiences hoarseness for longer than four
PERSEPHONE: Duration of trastuzumab with chemotherapy in women with HER2-positive early breast cancer—Six versus twelve months.
Authors: Helena Margaret Earl, David A. Cameron, David Miles, Andrew M. Wardley, Emma Ogburn, A-L Vallier, Shrushma Loi, Helen B Higgins, Louise Hiller, Janet A. Dunn
Journal: Journal of Clinical Oncology (2013)

TPS667 Background: PERSEPHONE is a randomised controlled trial comparing six months of trastuzumab to the standard 12 months in patients with HER2 positive early breast cancer. Methods: 4000 patients (pts) will be randomised into the two arms (1:1). The power calculations assume that the disease-free survival (DFS) of the standard treatment (12 months trastuzumab) is 80% at 4 years. Randomisation of 4000 pts will allow the trial to prove non-inferiority of six months trastuzumab (5% 1-sided significance and 85% power). Non-inferiority is defined as ‘no worse than 3%’ below the control arm (12 month) 4 year DFS. Primary outcome is DFS, and secondary outcomes are overall survival (OS) non-inferiority; cost effectiveness; cardiac function and quality of life. Tumour blocks are collected to research molecular predictors of survival with respect to duration of trastuzumab treatment. Blood samples are analysed for single nucleotide polymorphisms (SNPs) as pharmaco-genetic determinants of prognosis, toxicity and treatment outcome. PHARE, a similar trial from the Institut National du Cancer in France, closed to recruitment in 2010 and presented early data at ESMO 2012. Following this an unplanned interim analysis of PERSEPHONE was presented to the Data Monitoring and Safety Committee (DMSC). PERSEPHONE is funded by the NIHR HTA programme in the UK. Results: PERSEPHONE commenced recruitment in October 2007. At abstract submission, 2593 pts (65%) had been randomised from 144 UK sites. Recruitment is due to complete in September 2014 with the first planned interim analysis of the primary outcome mid-2016. The iDMSC reviewed all data available on HERA and PHARE as well as a PERSEPHONE interim analysis. There were no safety findings or signals that would warrant a change of the study plan and the high quality of data returns was noted. Conclusion: PERSEPHONE continues the active recruitment phase as planned. Preliminary but inconclusive PHARE data have reinforced interest in the PERSEPHONE trial both nationally and internationally. There has been full support from the Breast International Group (BIG) and the international breast cancer community to answer this important shorter duration question. Clinical trial information: 52968807.
ECC Committee, ECC Subcommittees, and ECC Task Forces; and Authors of Final Evidence Evaluation Worksheets 2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care With Treatment Recommendations Conference
Authors: Tom Aufderheide, Edward Stapleton, Andrea Gabrielli, Thomas Barnes, Monica Kleinman, Ricardo Samson, Dianne Atkins, Susan Fuchs, Linda Quan, Pediatric Defibrillation, Allan De Caen, Ashraf Coovadia, Charles Schleien, Venkataramani Ramesh, Pediatric Arrhythmias, Elise Van Der Jaght, Vijay Srinivasan, Amelia Reis, Melinda Fiedor, Paul Shore, Peter Kudenchuk, Acls Arrhythmias, Mark Link, Henry Halperin, Hans-Richard Arntz, Joseph Ornato, Michelle Acs, Warren Welsford, Steven Cantor, Carolyn Brooks, John Zelop, Kathleen Morris, Jared Jobe, Special Strote, Situations Resuscitation, Garry Frank, Karen Lapidus, Curtis Brock, Mary Snook, Postresuscitation Peberdy, Robert Care, Postresuscitation Neumar, David Care, Theodore Gilmore, Jeffrey Delbridge, Peter Saver, Les Viccellio, David Rodgers, John Billi, Robert Hickey, Vinay Nadkarni, Robert O'connor, Vice Chair, Max Weil, Graham Nichol, Ahamed Idris, Walt Stoy, Stephen Schexnayder, William Mcconnell, Mark Mattes, Todd Crocco, Theodore Delbridge, Diana Fendya, Terry Vanden Hoek, Edward Jauch, Rashmi Kothari, Steven Kronick, Charles Otto, Norman Paradis, Mary Peberdy, Edward Racht, Michael Sayre, Lance Becker, Diana Cave, Keith Lurie, Vincent Mosesso, Tom Rea, Wanchun Tang, Roger White, Laurie Morrison, P Verbeek, Steven Brooks, Warren Cantor, Michelle Welsford, Benjamin Abella, Riyad Abu-Laban, Imo Aisiku, Sherri-Lynne Almeida, Charles Babbs, Joseph Thomas, A Barnes, Jason Bartsch, Michael Baubin, David Beiser, Robert Berg, Ross Berringer, Adnan Bhutta, Dominique Biarent, Robert Bingham, Richard Bissell, Bjug Borgundvaag, Leo Bossaert, Michael Bosse, Bernd Böttiger, David Boyle, William Brady, Richard Branson, Franklin Bridgewater, Fabrice Brunet, Cartland Burns, Steve Byrne, Rebecca Cain, Rick Caissie, Pierre Carli, Wally Carlo, Renato Carrera, Dan Cass, Antonio Celenza, Leon Chameides, Ivy Cheng, Seshendra Chirumamilla, Gregory Christiansen, Bill Clendenen, Sharon Coleman, David Cone, Arthur Cooper, Peter Cram, Michelle Cretikos, Edward Crosby, Ricky Davidson, Mary Davis, Edison Ferreira De Paiva, Rien De Vos, Charles Deakin, Jennifer Dennett, Andrew Depiero, Douglas Diekema, Burkhard Dirks, Hans Domanovits, Volker Dörges, Trygve Eftestøl, Christoph Dring, Nabil Eich, William Sanadi, Jonathan Engle, Marilyn Epstein, Octavio Escobedo, Peter Falcucci, Melinda Fenici, Judith Fiedor, Matthias Finn
Journal: Circulation (2005)
Physical fitness in United States and Austrian military personnel. A comparative study
Authors: K. H. Cooper
Journal: JAMA (1971)

A difference between the United States and Austria in number of deaths from heart attacks among men 35 to 44 years of age aroused considerable interest with respect to the role of physical activity. The purpose of the present study was to evaluate the level of physical fitness of younger men, ie, 18 to 29 years of age, in the US Air Force and the Austrian Army. A marked difference in endurance performance was observed on a 12-minute field test of performance irrespective of the stage of training or the age, even though the Austrian soldiers weighed more and a comparable percentage of them smoked cigarettes. The results indicate that the 12-minute field test is a good substitute for the laboratory-determined maximal oxygen consumption if the subjects are well motivated.
Complete pathologic response after combined modality treatment for rectal cancer and long-term survivals: A meta-analysis.
Authors: L. Zorcolo, A. S. Rosman, A. Restivo, M. Pisano, G. R. Nigri, A. Fancellu, M. Melis
Journal: Journal of Clinical Oncology (2011)

e14008 Background: Recent literature suggests that a complete pathologic response (CPR) following neoadjuvant chemoradiotherapy (combined modality treatment, CMT) for rectal cancer is associated with improved survivals compared to partial or no response (NPR). However, previous reports have been limited by small sample size and single-institution design. To overcome these limitations, we performed a meta-analysis of studies evaluating the prognostic value of CPR. Methods: A systematic literature review was conducted to detect studies comparing long-term results of patients with CPR or NPR after CMT for rectal cancer. Variables were pooled only if evaluated by 3 or more studies. Both qualitative and quantitative data were pooled using a random-effects model. Study endpoints included rates of complete pathological response, local recurrence (LR), distant recurrence (DR), as well as 5-year overall (OS) and disease-free survival (DFS). Results: There were 13 studies suitable for the meta-analysis, that overall reported on outcomes of 2,030 patients with rectal cancer treated with CMT. CPR was achieved in 332 patients (16.4%). CPR and NPR patients groups were similar with respect to age, male gender, tumor size, distance of tumor from the anus and pre-treatment stage (p > 0.3 for all comparisons). Median follow-up ranged from 23.5 to 46 months. CPR patients had lower rates of LR (0.7% vs. 2.6%; odds ratio [OR]=0.45, 95% CI 0.22–0.90), DR (5.3% vs. 24.1%; OR=0.15, 95% CI 0.07–0.31) and LR+DR (0.7% vs. 4.8%; OR=0.32, 95% CI 0.13–0.79). OS was 92.6% for CPR vs. 73.2% for NPR (OR=3.6, 95% CI 1.84–7.06), and DFS was 89.1% vs. 64.3% (OR=4.3, 95% CI 1.8-10.1). Conclusions: Meta-analysis confirms that a CPR following CMT for rectal cancer is associated with an improved local and distal control as well enhanced OS and DFS.
The impact of comorbid and sociodemographic factors on access to renal transplantation
Authors: D. S. Gaylin
Journal: JAMA (1993)

<h3>Objective.</h3> —To assess the impact of sociodemographic factors and comorbid conditions on access to renal transplantation for adult US dialysis patients with end-stage renal disease (ESRD). <h3>Design.</h3> —Cohort analytic study. Data on comorbid conditions at onset of ESRD were abstracted from patients' medical records and matched to sociodemographic and ESRD data from the United States Renal Data System database. <h3>Setting.</h3> —United States Medicare dialysis population. Patients.—Random, national sample of ESRD patients starting dialysis in 1986 and 1987 (n=4118). <h3>Main Outcome Measure.</h3> —Time to first renal transplant (living or cadaver donor) since onset of ESRD regressed with two nested Cox proportional hazards models, first against sociodemographic factors alone, and then against sociodemographic factors and comorbid conditions. <h3>Results.</h3> —Cardiovascular diseases are most predictive of who receives a transplant; patients with coronary heart disease, congestive heart failure, or left ventricular hypertrophy showed lower transplantation rates relative to patients without the disease (relative rate [RR] = 0.65 to 0.80,<i>P</i>&lt;.05 each). Obese patients and patients with peripheral vascular disease also showed lower transplantation rates (RR = 0.65 to 0.75,<i>P</i>&lt;.05 each). Previously reported sociodemographic effects of lower transplantation rates for older patients, women, nonwhite patients, and lower income patients were confirmed (<i>P</i>&lt;.01). Sociodemographic effects remained essentially unchanged when adjusted for comorbid conditions. <h3>Conclusions.</h3> —These findings indicate that sociodemographics have strong independent effects on access to transplantation that cannot be explained away as "surrogate" effects related to comorbid factors. Furthermore, the results suggest that lower mortality rates for transplant recipients relative to dialysis patients are due, in part, to a healthier case mix among patients receiving transplants. (<i>JAMA</i>. 1993;269:603-608)
MSG
Authors: A. G. Ebert
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The letter by Bartoshuk et al (230:670, 1974) on the saltiness of monosodium glutamate (MSG) and sodium intake is so erroneous in conception and experimental design that corrective information must be brought to readers ofThe Journal. The authors assume that MSG is used to enhance the various single components of taste, in this case, perception of saltiness. This is untrue. The function of MSG as a flavor enhancer appears to be that of blending and bringing out those flavors naturally present in food.<sup>1,2</sup>In the Orient, glutamate is used at markedly higher levels than those employed in the United States because a fifth basic taste of glutamate is desired. However, to Occidental taste preferences, the levels employed to create a unique glutamate taste are considered unpalatable. Monosodium glutamate has been and is used by persons wishing to reduce sodium intake, as it is synergistic with
Education for Family Life. Nineteenth Yearbook
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Empedocles' Medical Philosophy
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proceedings of the Kansas State Medical Society.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fiction
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
School-Based Tobacco-Use Prevention—People's Republic of China, May 1989-January 1990
Journal: JAMA (1993)

Tobacco consumption has increased markedly in the People's Republic of China (PRC) since the 1960s (1,2). In 1984, when the prevalence of cigarette smoking was 61% among men and 7% among women, approximately 250 million persons in PRC smoked tobacco products (1). In 1988, among junior high school students in PRC, 34% of boys and 4% of girls reported smoking at least occasionally (3). To increase public knowledge of the health consequences of cigarette smoking, promote healthier attitudes among elementary school students, and motivate fathers who smoke to quit, the Zhejiang Center for Health Education developed and implemented a school-based smoking-intervention program in the Jiangan district of Hangzhou from May 1989 through January 1990. This report summarizes an assessment of this program.
Hyperadrenergic state after trauma to the neuroaxis
Authors: J. Wortsman
Journal: JAMA (1980)

INCREASED catecholamine excretion rates have been reported in pheochromocytoma, congestive heart failure, myocardial infarction, cerebrovascular accident,<sup>1</sup>and CNS trauma.<sup>2</sup>This article describes a patient who had persistent hypertension associated with elevated catecholamine excretion rates subsequent to trauma to the CNS. This pheochromocytomalike syndrome may be a common complication of trauma to the CNS. <h3>Report of a Case</h3> A 40-year-old man was hospitalized after being involved in a high-speed boating accident. At the time of the accident, the patient lost consciousness for one to two minutes; however, there were no external signs of injury to the head. On initial examination, the patient was in no acute distress. Blood pressure was 140/90 mm Hg while he was supine, and the pulse rate was 90 beats per minute and regular. There was complete paralysis of the right arm, with swelling of the right cervical region extending down to the arm. Roentgenograms
<b>“Public health and medicolegal implications of sleep apnoea”. W.T. McNicholas and J. Krieger on behalf of the Task Force members.<i>Eur Respir J</i>2002; 20: 1594–1609.</b>
Journal: European Respiratory Journal (2003)

Unfortunately, the authorship sequence was inadvertently reversed during the publication process and should have read J. Krieger and
What's the evidence that NICE guidance has been implemented?: Author's reply
Authors: Nick Freemantle
Journal: BMJ (2005)

This week in the BMJ for the paper by Walsh et al are offered the conclusion that investment in intermediate care in community hospitals may be more cost effective than financing nurse led care for post-acute patients in acute hospitals. 1 2But the study itself, which confirms existing evidence on the costs of nurse led intermediate care in acute settings, 3 4 tackles neither the effect nor the cost of intermediate care in community hospitals.How then can such a conclusion be drawn?Walsh et al do not make this assertion.The author of the comment offers no support.Our own review of the evidence on nurse led intermediate care found no quality evidence for either the effect or cost of intermediate care in community settings. 5 The BMJ has been at the forefront of setting standards for the reporting of primary research.However, the editors must be aware that many readers simply pick up a take home message from comment, like this, 1 in the journal.
Lymphodepletion Followed by Donor Lymphocyte Infusions (DLI) Causes Significantly More Acute Graft Versus Host Disease Than DLI Alone.
Authors: Jeffrey S. Miller, Daniel J. Weisdorf, Linda J. Burns, Arne Slungaard, John E. Wagner, Michael R. Verneris, Sarah Cooley, Rosanna Wangen, Susan K. Fautsch, Roby Nicklow, Todd DeFor, Bruce R. Blazar
Journal: Blood (2006)
Regulations concerning Degrees, Diplomas, &amp;c., in Medicine
Journal: BMJ (1862)

of hospitals were inveigled into the movement we cannot say, but certain it is that, the example once set, every hospital in the metropolis felt a call to teach, and so far succeeded, that now every hospital has its school with its cbairs, chairs, chairs.There is only one of the oriainal schools left, a little school on which the Marquis of Westminster, to whom it wvill come one day, is said to have implanted a withering eye.
Sleep specialists weigh hypnotics, behavioral therapies for insomnia
Authors: L. Lamberg
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal