tbuckley/cabot-search huggingface dataset:
Joseph Lowry
Journal: BMJ (2005)

A pioneer of open heart surgeryBill Cleland was one of the surgeons who developed open heart surgery in London in the late 1950s.He was at Hammersmith Hospital in 1952-3 when Professor Dennis Melrose developed the first heart-lung machine.Melrose and Cleland conducted extensive animal tests before trying the machine in 1953 on patients whose prognosis was poor.In the early days there were postoperative deaths, which taught them the importance of meticulous postoperative care, and the clinical programme was restarted successfully in 1957.Cleland was one of the machine's earliest users, and it enabled him to perform a wide range of new operations, specialising in mitral valvotomy, the surgical treatment of ventricular septal defect, and aortic valve replacement.He was the first to operate on the newly identified condition of obstructive cardiomyopathy-known in the United States as hypertrophic subaortic stenosisby excising muscle from the interventricular septum via the aortic valve.Russian surgeons were impressed by Melrose's heart-lung machine, and Professor Aleksandr Bakulev from the then Soviet Union bought one; he then invited the Hammersmith team to operate in Moscow in May 1959.It was at the height of the cold war and they were the first foreign doctors to perform surgery there.Melrose, Cleland, and another surgeon, Hugh Bentall, went.The Russians chose two adults and four children with congenital heart defects.Two of them had Fallot's tetralogy, which Cleland and his colleagues had never operated on before.All six operations were successful.Cleland remarked that this was helped by God, who had so little to do in Russia that he was able to give the children his undivided attention.The trip was a success in other ways.Cleland took his cine camera and filmed the army parade in Red Square, and was astonished not to be arrested.The team then returned on the inaugural UK flight of the Tupolev 104, the Soviet Union's first jet powered passenger airliner.Cleland was a meticulous surgeon, possessed of great energy, and a great teacher.He was warm hearted, and remained calm in emergencies.He was
Feasibility of breast conserving treatment for breast cancer in women with germline <i>BRCA</i> mutations: A clinic-based series
Authors: M. Robson, T. Holcombe, B. McCormick, P. Borgen, T. Gulati, S. Jhanwar, N. Kauff, C. Hudis, L. Norton, K. Offit
Journal: Journal of Clinical Oncology (2004)

9618 Background: The management of women with BRCA-associated hereditary breast cancer (BAHBC) remains incompletely defined. We evaluated the appropriateness of breast conserving therapy (BCT) in women with BAHBC. Methods: Between May 1992 and December 2003, 103 female participants in genetic testing protocols were identified with deleterious BRCA mutations (72 BRCA1, 31 BRCA2), whose initial treatment for breast cancer was wide local excision (WLE). Clinical records were reviewed and follow-up updated. Results: The 103 women underwent WLE for 115 BAHBC (108 invasive, 7 DCIS). In 17 cases, RT was not delivered (16 prophylactic mastectomy after WLE but before RT, 1 active ovarian cancer). There were 91 cases of invasive BAHBC (65 BRCA1, 26 BRCA2) treated with both WLE and RT. Median age at diagnosis was 43 years, and median follow-up was 65.7 months (12.8–234.6). There were 11 cases (9 DCIS, 2 invasive) of metachronous ipsilateral breast cancer (MIBC). The risk of MIBC was 11.5% at 60 months and 14.0% at 120 months. No factors predictive of MIBC were identified among women with BAHBC. In all 103 women, the risk of contralateral breast cancer was 13.7% at 60 months and 39.1% at 120 months. The mean interval from first BC diagnosis to genetic testing was significantly longer in women with CBC. Conclusions: Women with BAHBC undergoing BCT have similar risk of early MIBC as unselected young women, and the indications for therapeutic mastectomy are the same as in women with non-hereditary cancer. However, the significant risks of CBC and possibly late MIBC may prompt serious consideration of bilateral mastectomy as a preventive measure. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Myriad Genetics
Chimeric Anti-CD20 Monoclonal Antibody (Rituximab;Mabthera) in Remission Induction and Maintenance Treatment of Relapsed /Resistant Follicular Non-Hodgkin’s Lymphoma: Final Analysis of a Phase III Randomized Intergroup Clinical Trial.
Authors: Marinus H.J. Van Oers, Martine Van Glabbeke, Ivana Teodorovic, Cynthia Rozewicz, Richard Klasa, Robert E. Marcus, Max Wolf, Eva Kimby, Anton Hagenbeek
Journal: Blood (2005)
Intractable vomiting from glioblastoma metastatic to the fourth ventricle: Three case studies
Authors: Zvi R. Cohen, Samuel J. Hassenbusch, Moshe H. Maor, Raphael M. Pfeffer, Zvi Ram
Journal: Neuro-Oncology (2002)

Neuro-OncologyDissemination of malignant glioma to the fourth ventricle with metastatic deposits and intractable vomiting is rare.Leptomeningeal extension of malignant glioma is an uncommon condition that has been reported in patients with end-stage disease and is usually unresponsive to any treatment modality.We describe 3 patients with progressing recurrent glioblastoma multiforme in whom leptomeningeal invasion manifested itself as intractable vomiting due to tumor metastases in the oor of the fourth ventricle.All patients received additional radiation therapy focused to the posterior fossa, with complete resolution of vomiting occurring within 10 days after irradiation.The remission of symptoms in these patients persisted until their death 3-4 months after the repeat radiation therapy.These reports indicate that additional focused radiation should be considered because of its signi cant therapeutic effect in alleviating intractable nausea and vomiting in patients with glioma metastasized to the posterior fossa.
Evaluation of Prostate Cancer Detection with Ultrasound Real-Time Elastography: A Comparison with Step Section Pathological Analysis after Radical Prostatectomy
Authors: Georg Salomon, Jens Köllerman, Imke Thederan, Felix K.H. Chun, Lars Budäus, Thorsten Schlomm, Hendrik Isbarn, Hans Heinzer, Hartwig Huland, Markus Graefen
Journal: European Urology (2008)
Mandibular Fractures with Plastic Polymers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P3.04-11 The Influence of Circulating Tumor DNA Analysis on Response to Immunotherapy in Non-Small Cell Lung Cancer (NSCLC)
Authors: R. Grinberg, L. Roisman, S. Geva, M. Lefterova, K. Quinn, L. Soussan Gutman, A. Dvir, R. Yair, T. Twito, R. Lanman, N. Peled
Journal: Journal of Thoracic Oncology (2018)
Pathologists request autopsy revival
Authors: C. Marwick
Journal: JAMA (1995)

TO LOOK AT the data, the practice of autopsy is a dying procedure. Thirty years ago around 50% of hospital deaths were autopsied. Since then there has been a steady decline, so that today in teaching hospitals only 10% to 20% of deaths are autopsied. In community hospitals, the rate is probably below 5%— and the trend continues downward. "American health care policymakers have relegated the role of autopsy to the back burner of health care reform," said Paul Raslavicus, MD, secretary-treasurer of the College of American Pathologists. The situation worries those who think the autopsy is a valuable tool for the improvement of medical care. "Medicine needs the autopsy. It is the one place where truth can be sought, found, and told without conflicts of interest," said George D. Lundberg, MD, editor-in-chief of the<i>Journal of the American Medical Association</i>. Raslavicus and Lundberg were among the speakers at a
Management of chemotherapy‐induced anemia (CIA) with biosimilar epoetin alfa (Binocrit) in patients with colorectal cancer (CC): An interim analysis of an ongoing French national observational study (The OncoBOS study).
Authors: Jean Philippe Metges, Jean-Pierre Crumbach, Daniela Petran, Vincent Boulanger, Otilia Stamerra, Jérôme Desramé, Sophie Nahon, Camille Aubron-Olivier, Domitille Fernet, Gilles Boschetti
Journal: Journal of Clinical Oncology (2015)

742 Background: OncoBOS is a prospective, non-interventional study describing Binocrit use in routine practice in France in patients receiving chemotherapy treatment (CT) for solid tumors, lymphoma, or myeloma. This interim sub-analysis focuses on patients with CC, receiving usual chemotherapeutic agents. Methods: Patients ≥18 years with CC, CIA, and eligible for treatment with Binocrit were included in this analysis. Patients characteristics, data on CIA and its management, and predominant factors considered by the physician in prescribing Binocrit were recorded at baseline (BL), 3-4 weeks and 12 (±1) weeks later. Hemoglobin (Hb) outcomes assessed included the proportion of patients achieving a Hb increase ≥1 and ≥2 g/dL, and the mean Hb change from BL. Results: 96 patients with CC (51 males [53.1%], mean age 68.5 years) from 28 sites were recruited from September 2011 to April 2014. Mean and median BL Hb levels were 9.9 g/dL and 10 g/dL, respectively. The mean increase in Hb level was 1.2 g/dL after 1 month and 1.7 g/dL after 3 months (p&lt;0.001 vs. BL) of Binocrit treatment. A Hb increase ≥1 g/dL was achieved by 56.8% of patients at week 3-4 and 77.6% at week 12; a Hb increase ≥2 g/dL was achieved by 17.9% and 47.4% of patients at the same time points. Patients received a median dose of 30,000 IU Binocrit once weekly. Four of the 96 patients (4.2%) required a dose increase. Transfusion rates remained low at 2.1% and 1.1% at week 3-4 and week 12, respectively. Oral and intravenous (IV) iron supplementation rates were low: oral iron was received by 4.2% and 4.7% of patients at week 3-4 and week 12, respectively; 15.6% and 9.3% of patients received IV supplementation at the same time points. Physicians considered quality of life (49%), fatigue (24%), and avoidance of blood transfusion (15.6%) as predominant factors in the rationale for CIA management. Over the treatment period, no treatment-related adverse reaction was recorded. Conclusions: This sub-analysis indicates that Binocrit, used in routine practice, is effective and well tolerated for the treatment of CIA in patients with CC, whatever CT received.
TUMORS OF THE PANCREAS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Council on Drugs. List No. 80. New names
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuropsychological Impairment
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential diagnosis and heuristics
Authors: D. A. Nardone
Journal: JAMA (1985)

<h3>In Reply.—</h3> Dr Nicholson is correct in saying that lidocaine poisoning occurs both by acute overdose as well as by inappropriately high long-term infusion rates. We have shown the value of cardiac bypass support only in the acute overdose setting.<sup>1</sup>However, contrary to Dr Nicholson's assertion, we believe that restoring normal cardiac output with extracorporeal pumping would probably lead to normal clearance of lidocaine in patients with heart failure since lidocaine clearance is primarily related to hepatic blood flow. If normal clearance and distribution were restored, then the halflife of elimination of the lidocaine would be about 1.5 hours, so that short-term bypass support would be practical for eliminating a substantial fraction of the overdose. A heroic technique such as cardiac bypass can only be justified in a life-threatening setting in which lidocaine has produced refractory arrhythmias or profound hypotension. Most patients intoxicated by a longterm infusion can simply
Chemoradiotherapy versus surgery for clinical stage I esophageal squamous cell carcinoma: A long-term comparison
Authors: S. Mitani, S. Kadowaki, I. Oze, T. Masuishi, Y. Narita, H. Taniguchi, T. Ura, M. Ando, M. Tajika, C. Makita, T. Kodaira, N. Uemura, T. Abe, K. Muro
Journal: Annals of Oncology (2016)
State of the Union
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Resurgence Of Acute Rheumatic Fever In The United States
Authors: A. Bisno
Journal: Annual Review of Medicine (1990)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More
Treatment of Acute Posttraumatic Stress Disorder With Brief Cognitive Behavioral Therapy: A Randomized Controlled Trial
Authors: Marit Sijbrandij
Journal: American Journal of Psychiatry (2007)

Objective: The purpose of this study was to evaluate the efficacy of brief cognitive behavioral therapy for patients with acute posttraumatic stress disorder (PTSD) resulting from various types of psychological trauma. Method: The authors randomly assigned 143 patients with acute PTSD (irrespective of the time criterion), within 3 months after experiencing a traumatic incident, to either brief cognitive behavioral therapy (N=79) or a waiting list comparison group (N=64). Cognitive behavioral therapy consisted of four weekly sessions containing education, relaxation exercises, imaginal exposure, in vivo exposure, and cognitive restructuring. Main outcome measure was PTSD score measured by structured interview; secondary outcomes were anxiety and depression measured by questionnaire. Assessments took place before the intervention and 1 week and 4 months after the intervention. Results: Symptoms of PTSD, anxiety, and depression decreased in both groups over time. One week after the intervention, the cognitive behavioral therapy group had significantly fewer symptoms of PTSD than the comparison group, but this difference was smaller and no longer significant 4 months after the intervention. Similar results were found for anxiety and depression scores. Subgroup analyses showed that cognitive behavioral therapy led to significantly lower PTSD scores at 4 months in patients with baseline comorbid major depression and in patients who were included within the first month after the traumatic incident both at 1 week and at 4 months. Conclusions: Brief early cognitive behavioral therapy accelerated recovery from symptoms of acute PTSD but did not influence long-term results. Brief early cognitive behavioral therapy showed enhanced efficacy in patients with baseline comorbid depression and patients who were included within 1 month after their traumatic experience.
Book Review
Authors: Miguel A. Leibovich, Nicholas A. Covino, Jerald F. Dirks, Ralph I. Fisch, John V. Seidel, Louis A. Gottschalk, William D. Welch, Jordan Weiss, Tetsuhiko Aono, Hisashi Kumashiro, Joseph J. Marbach, David M. Richlin, James A. Lipton, G.N. Christodoulou, B.H. Alevizos, E. Konstantakakis
Journal: Psychotherapy and Psychosomatics (1983)
THE EARLY RECOGNITION OF SMALLPOX.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bile leakage after fracture of a percutaneous transhepatic biliary drainage catheter
Authors: D. D. Nghiem
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Percutaneous transhepatic biliary drainage (PTBD) has recently gained popularity in the management of obstructive jaundice. Nevertheless, it is not without complication. Fracture of the PTBD catheter can occur and result in massive bile peritonitis. <h3>Report of a Case.—</h3> An 86-year-old woman was admitted to the hospital for extrahepatic ductal obstruction. Laboratory studies disclosed the following values: serum alkaline phosphatase, 350 units/dL; SGOT, 194 units; SGOT, 232 units; total bilirubin, 20 mg; serum amylase, 422 units/L; aspartate aminotransferase, 90 IU; total protein, 5.7 g; albumin, 1.7 g; serum calcium, 5.1 mg; WBCs, 12,200/cu mm; and hematocrit, 27%. Guaiac-positive stools were present. Under antibiotic coverage, she underwent percutaneous transhepatic cholangiography and insertion of 7F catheter (Cook pigtail catheter) for biliary drainage. Within 24 hours, the bilirubin level decreased to 14.6 mg/mL. Two days later, bile drainage decreased suddenly to 500 ml/24 hr, while the total bilirubin level increased to
Direct coronary stenting without balloon predilation: Immediate and 6 month results of a multicenter prospective randomized trial Marc Bedossa, Philippe Commeau, Philippe Brunnel, Martine Gilard, Christian Breut, Philippe Geslin, Ashok Tirouvanziam, Luc Maillard, Benoit Moquet, Paul Barragan, Patrick Dupouy, Cristophe Leclercq, Herve Le Breton. Dept of Cardiology. University Hospital, Rennes, France
Journal: Journal of the American College of Cardiology (2001)