tbuckley/cabot-search huggingface dataset:
Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomized controlled feasibility trial
Authors: M. Klonizakis, G.A. Tew, A. Gumber, H. Crank, B. King, G. Middleton, J.A. Michaels
Journal: British Journal of Dermatology (2018)

Venous leg ulcers (open sores) can be caused by a blockage or breakdown in the veins of the leg. Compression, using bandages or hosiery (stockings), can help heal ulcers, however, they do not always work. Venous ulcer patients are often encouraged to exercise, but little is known about the effects and safety of exercise training in this population. This study therefore tried out supervised exercise training in people in the U.K. who are being treated with compression for a venous leg ulcer. Participants were randomly allocated to receive usual care, or usual care plus a 12‐week supervised exercise programme. The exercise programme involved three sessions per week, with each session involving a combination of walking, cycling and strength and flexibility exercises for the leg muscles. Participants were followed for up to 1 year, with data collected on ulcer healing, quality of life and healthcare use (e.g. visits to GP). Thirty‐nine people were recruited, with 18 being allocated to the exercise group. All but two participants completed the study. The overall exercise session attendance rate was 79%, with 13 participants (72%) completing all sessions. There were no serious adverse events (unwanted side effects). The average ulcer healing time was shorter for the exercise group: 13 versus 35 weeks. These findings support the feasibility of supervised exercise training in people being treated with compression for a venous leg ulcer. A larger study is needed to confirm the effects on ulcer healing and if exercise is cost‐effective.
TREM-1 expression in HPV-related oropharyngeal squamous cell carcinoma.
Authors: Mario Airoldi, Luca Raimondo, Barbara Azzimonti, Luigi Chiusa, Giancarlo Pecorari, Paola Cappello, Tiziana Cena, Guido Valente
Journal: Journal of Clinical Oncology (2019)

e17545 Background: Immunotherapy in head and neck squamous cell carcinoma (SCC) is a hot topic and PD1/PDL-1 checkpoint blockade is a promising approach even if there is a lack of robust progno-stic/predictive biomarkers and treatment benefits in overall survival are variable. Triggering Receptor Expressed on Myeloid cell 1 (TREM-1) reverses the M2-polarizing effect of hypoxia imparting a M1-skewed pro-inflammatory phenotype to macrophages that controls tumour growth. Aim of this study is to evaluate the prognostic role of TREM-1 in oropharyngeal (OP) SCC. Methods: In 25 patients with stage III-IV HPV+ OPSCC we evaluated, with immunohistochemistry, in surgical specimens the following immunologic parameters in intratumoral (IT) and peritumoral (PT) environment: PD1-PDL-1 (1+ = &lt; 20% positive cells (pc); 2+ = 21-50% pc; 3+ = &gt; 50% pc) CD4, CD8, FOXP3 (1+ = &lt; 10% pc; 2+ = 10-20% pc ; 3+ = &gt; 20% pc) IL22 (1+ = 1-33% pc, 2+ = 34-67% pc, 3+ = &gt; 67% pc) and TREM ( 1+ = 1-50% pc, 2+ = &gt; 50% pc). The McNemar test was used to assess differences between IT and PT environment. Results: CD4 IT 0/1+ = 12% 2+/3+ = 88% PT 0/1+ = 6% 2+/3+ = 94% FOXP3 IT 0/1+ = 88% 2+/3+ = 12% PT 0/1+ = 65% 2+/3+ = 35% CD8 IT 0/1+ = 12% 2+/3+ = 88% PT 0/1+ = 48% 2+/3+ = 52% PD1 IT 0/1+ = 100% 2+/3+ = 0% PT 0/1+ = 100% 2+/3+ = 0% PDL1 IT 0/1+ = 53% 2+/3+ = 47% PT 0/1+ = 6% 2+/3+ = 94% IL22 IT 0/1+ = 59% 2+/3+ = 41% PT 0/1+ = 29% 2+/3+ = 71% TREM-1 IT 0/1+ = 94% 2 + = 6% PT 0/1+ = 82%* 2+ = 18% * 1+ = 64% Statistical analysis showed a concordant expression of CD4, CD8 and PDL-1 both in IT and PT while TREM-1 was more expressed in PT (p = .001) and PD-1 in IT (p = 0.12).There was no correlation between TREM-1 pc and CD68 and CD35 pc. Tumours with low PT TREM-1 positivity have a lowest risk of relapse (p = .01). Conclusions: HPV+ OPSCC is promoted by inflammatory infiltrate anergy. TREM-1 PT positivity has unfavourable impact on relapse.
Transfusion-related cytomegalovirus infection following noncardiac surgery
Authors: W. L. Drew
Journal: JAMA (1982)

Clinically evident cytomegalovirus (CMV) infections developed in five patients after noncardiac surgery. Each of them had received several blood transfusions and had evidence of primary CMV infection. These five cases were identified in a single eight-month period, suggesting that this syndrome must be occurring with greater frequency than is commonly appreciated. Three of the five patients had undergone splenectomy, and review of the literature for documented cases of posttransfusion CMV mononucleosis following non-cardiac-bypass surgery disclosed an additional nine patients, five of whom had had splenectomies. This striking association suggests the possibility that the spleen plays a role in controlling the incidence or clinical manifestations of posttransfusion CMV infections. Alternatively, this association may only reflect the frequent requirement for many blood transfusions in this type of surgery. (<i>JAMA</i>1982;247:2389-2391)
Response to Letter Regarding Article, “Association of Leukocyte Telomere Length With Circulating Biomarkers of the Renin-Angiotensin-Aldosterone System: The Framingham Heart Study”
Authors: Ramachandran S. Vasan, Serkalem Demissie, L. Adrienne Cupples, Emelia J. Benjamin, Charles White, Masayuki Kimura, Jeffrey P. Gardner, Xiaogian Cao, Abraham Aviv, Nader Rifai, Thomas J. Wang, Daniel Levy
Journal: Circulation (2008)
Bacterial Endocarditis Due to A Group C Beta Hemolytic Streptococcus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE UVEAL TRACT
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Single-Nutrient Effects on Immunologic Functions
Authors: William R. Beisel
Journal: JAMA (1981)

Immune system dysfunction can result from single-nutrient deficiencies or excesses, alone or in combination with generalized protein-energy malnutrition. Acquired immune dysfunctions in man occur with deficiencies of iron, zinc, vitamins A and B<sub>12</sub>, pyridoxine, and folic acid and with excesses of essential fatty acids and vitamin E. Additional micronutrients are important for maintaining immunologic competence in animals. Deficits or excesses of many trace elements and single nutrients thus have potential for causing immune dysfunctions in man. Since nutritionally induced immune dysfunction is generally reversible, it is important to recognize and identify clinical illnesses in which immunologic dysfunctions are of nutritional origin. Correction of malnutrition should lead to prompt reversal of acquired immune dysfunctions. (<i>JAMA</i>1981;245:53-58)
Health Implications of Environmental Exposure to Asbestos
Authors: J. Corbett McDonald
Journal: Environmental Health Perspectives (1985)

The health impact of environmental pollution resulting from the industrial use of asbestos can be assessed in three ways. First, there are the direct epidemiological surveys. These indicate that domestic exposure has been responsible for cases of mesothelioma and possibly lung cancer and radiological changes in family contacts of asbestos workers. Exposure in the neighborhood of crocidolite mines and factories has also resulted in cases of mesothelioma but no similar evidence exists for chrysotile or amosite. Neither air nor water pollution has been directly incriminated as a cause of either respiratory or digestive malignancies. Second, a few attempts have been made to extrapolate from exposure response findings in industrial cohorts. For several reasons, even for lung cancer, this approach is dubious: the observed gradients have a 100-fold range in slope; the equivalences of dust, fiber and gravimetric measures are largely guesswork; and the carcinogenic potential of mineral fibers, particularly for the pleura, varies enormously with fiber type and/or dimensions. No adequate exposure-response observations have been made for mesothelioma. A third approach makes use of the differing incidence of mesothelioma in men and women. Data from several countries indicate that, until the 1950s (i.e., 30-40 years after significant industrial use of asbestos began), the rates were similar in both sexes. Since then, the incidence in males has risen steeply--in the U.S. and U.K. at about 10% per annum. In females, on the other hand, there has been little or no convincing increase. These data suggest that the "background" level of mesothelioma in both sexes is and has been about 2 per million per annum and that--as at least some mesothelioma cases in females are directly or indirectly attributable to occupational exposure--there is little room left for any contribution from the general environment. It is recommended that mesothelioma surveillance, backed by appropriate epidemiological inquiries, offers an effective method of monitoring the health impact of asbestos air pollution.
Assessment of Lead Exposure in Schoolchildren from Jakarta
Authors: Inga Heinze, Rainer Gross, Peter Stehle, Drupadi Dillon
Journal: Environmental Health Perspectives (1998)

Children attending schools in urban areas with high traffic density are a high risk group for lead poisoning. We assessed the magnitude of lead exposure in schoolchildren from Jakarta by analyzing blood lead concentrations and biomarkers of heme biosynthesis. A total of 131 children from four public elementary schools in Jakarta (two in the southern district and two in the central district) were enrolled in the study. To evaluate lead pollution in each area, soil samples and tap water were collected. The mean blood lead concentration was higher in the central district than in the southern district (8.3 +/- 2.8 vs. 6.9 +/- 3.5 microg/100 ml; p<0.05); 26.7% of the children had lead levels greater than 10 microg/100 ml. In 24% of the children, zinc protoporphyrin concentrations were over 70 micromol/mol hemoglobin; in 17% of the samples, hemoglobin was less than 11 g/100 ml. All other values were within the physiological range. Blood lead concentration and hematological biomarkers were not correlated. Analyses of tap water revealed lead values under 0. 01 mg/l; lead contamination of soil ranged from 77 to 223 ppm. Our data indicate that Indonesian children living in urban areas are at increased risk for blood lead levels above the actual acceptable limit. Activities to reduce pollution (e.g., reduction of lead in gasoline) and continuous monitoring of lead exposure are strongly recommended.
Forty years of medical genetics
Authors: V. A. McKusick
Journal: JAMA (1989)

I AM often asked why I shifted from cardiology to medical genetics; I did not. In fact my activities in the two fields developed in parallel; it was a matter of phasing out cardiology and phasing in medical genetics. Indeed, my first published piece of clinical investigation was on a genetic topic, the syndrome of spots and polyps (1949), and my first book was<i>Heritable Disorders of Connective Tissue</i>(first published in 1956). In 1952 when I completed house-staff training there was no clinical discipline of medical genetics and no formal training program. So I trained in cardiology, which brought my attention to the Marfan syndrome because of the conspicuous cardiological complications. In the early 1950s, for 5 years after completing the chief residency at Johns Hopkins in Baltimore, Md, I was a junior faculty person. I pursued the analysis of heart sounds and murmurs by a method called<i>spectral</i>
DIETARY INVALIDISM
Authors: H J JOHN
Journal: Annals of Internal Medicine (1950)

Article1 April 1950DIETARY INVALIDISMHENRY J. JOHN, M.D., F.A.C.P.HENRY J. JOHN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-4-595 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDietary invalidism is an extremely large subject, with many ramifications, and it is impossible to make a thoroughly comprehensive survey of it in a talk of this kind. Naturally, since my practice is limited to the treatment of patients with diabetes, I think first of the examples I have encountered in my own experience. I shall begin by citing a few illustrative cases and problems observed in a diabetic practice which serve to bring forth some of the aspects of dietary invalidism. Then I shall proceed to point out some of the problems that may result from dietary treatment in...Bibliography1. John HJ: Hyperthyroidism showing carbohydrate metabolism disturbance, J. A. M. A. 99: 620-627, 1932. CrossrefGoogle Scholar2. John HJ: A liberal regimen of treatment of diabetes mellitus, Am. J. Med. 5: 537-547, 1948. CrossrefMedlineGoogle Scholar3. SpiesVitterDouglas TDRWG: Nutritional disorders in convalescence and rehabilitation; progress report, South. M. J. 37: 560-572, 1944. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Presented at the Thirtieth Annual Session of the American College of Physicians, New York, N. Y., March 29, 1949. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1950Volume 32, Issue 4Page: 595-610KeywordsPatients ePublished: 1 December 2008 Issue Published: 1 April 1950 Copyright & PermissionsCopyright, 1950, by The American College of PhysiciansPDF downloadLoading ...
"ATHLETIC STRENUOSITY"
Authors: G. H. Van Dyke
Journal: JAMA (1925)

<h3>To the Editor:</h3> —It gave me great pleasure to read your editorial on "Athletic Strenuosity." It is possible that it will not meet with favorable reception by a good many of your readers, but I am sure it is the kind of material that needs to be issued. I will be pleased to read it to my class in special physiology and hygiene—a class of twenty-three teachers of our state—a group of people who need just such information.
AND MADLY RIDE
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pregnancy prurigo.
Authors: J. E. Oni-Orisan
Journal: BMJ (1969)

MEDICALJOURNwomen who received daily doses of corticosteroids equivalent to 2-30 mg. of predni- sone that there was no correlation between corticosteroid dosage and urinary oestrogen excretion.It seems a little unwise, therefore, to argue, on the basis of a single estimation, that the reduction of the dose of corticosteroid in Dr. Driscoll's patient was responsible for the rise of the oestriol excretion to a normal value.What does the associated fall in preg- nanediol excretion reflect ?We would suggest that a controlled study of the many aspects of corticosteroid therapy in pregnancy is necessary and that in the meantime it would be wrong to read too much into reports of isolated cases.-Weare, etc.,
Congenital Malaria—Nassau County, New York, 2004
Journal: JAMA (2005)

Human malaria is a parasitic disease caused by four distinct species of intraerythrocytic protozoa of the genus Plasmodium. The parasites are transmitted to persons by the bite of an infective female Anopheles mosquito and rarely through blood transfusion and congenital transmission. The majority of malarial infections reported in the United States are acquired abroad by recent immigrants or persons returning from areas where malaria is endemic. This report describes the first documented case of congenital malaria acquired in Nassau County, New York, which is the fifth case of congenital malaria reported in the United States since 2000. Health-care providers should consider malaria as a diagnosis in neonates and young infants, particularly those with fever, whose mothers emigrated from areas where malaria is endemic.
GMC election
Authors: G. Wiseman
Journal: BMJ (1976)

Seven patients developed chronic and severe parkinsonism after repeatedly injecting 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intravenously. Levodopa and bromocriptine controlled the symptoms; however, within months, five of the seven patients experienced dyskinesias or on-off fluctuations. Therefore, neither prolonged levodopa treatment nor progressive disease was necessary for on-off phenomena. Because the neurotoxic effects of MPTP seem limited to the substantia nigra, damage to this system alone may produce all the motor features of Parkinson9s disease. MPTP differs from other neurotoxins in that it consistently produces a pure parkinsonian state.
Open-Heart Surgery and the Psyche
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunization Against Plague
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Satellite Dialysis
Authors: Steven Sieverts
Journal: JAMA (1972)

<h3>To the Editor.—</h3> TheSpecial Communicationregarding "Satellite Dialysis" (<b>218</b>:1809, 1971) is an important contribution to the field of areawide planning for the care of patients with renal disease. Bilinsky and his colleagues are to be commended for their imaginative leadership and for the careful analysis which they presented. Your readers may be interested to know that similar planning is under way in the greater Pittsburgh area, in which medical leadership and hospitals have agreed upon the designation of the University Health Center of Pittsburgh as the region's sole tertiary center for the care of patients with chronic renal failure. As such, the UHC's Presbyterian-University Hospital not only exercises the central role in treatment involving hemodialysis and kidney transplantation but also has the principal responsibility for professional education in hemodialysis-related activities as well as training programs for patients who will receive their dialyses at home. Initially, two large non-university