tbuckley/cabot-search huggingface dataset:
Costs and benefits of preemployment drug screening
Authors: C. Zwerling
Journal: JAMA (1992)

<h3>Objective.</h3> —This study provides a cost-benefit analysis of preemployment drug screening and evaluates the sensitivity of this analysis to variation in its underlying assumptions. <h3>Design.</h3> —Cost-benefit analysis, based on a cohort analytic study previously reported. <h3>Setting.</h3> —Employees of the US Postal Service in Boston, Mass. <h3>Participants.</h3> —Estimates of costs and benefit are based on a cohort of 2533 postal workers in Boston and on average costs for the Postal Service in Boston and nationwide. <h3>Results.</h3> —Drug screening would have saved the Postal Service $162 per applicant hired. However, these results were sensitive to the assumptions in the model. If the prevalence of drug use in the population screened were 1% rather than 12%, the program would lose money. Similarly, if the cost per urine sample screened were $95 rather than the $49 assumed, then the program would lose money, even if the prevalence of drug positives was as high as 9%. <h3>Conclusions.</h3> —Because of the sensitivity of this analysis to changes in its underlying assumptions, any company considering preemployment drug screening should carefully weigh the costs and benefits in its own industry. (<i>JAMA</i>. 1992;267:91-93)
Migration of medical manpower. Summary report of a Macy Conference
Authors: J. Z. Bowers
Journal: JAMA (1970)

An international conference on the Migration of Medical Manpower, sponsored by the Josiah Macy, Jr. Foundation of New York city, met at the Villa Serbelloni, Bellagio, Italy, on Oct 4 to 9, 1970. There were 19 participants representing 14 countries —Australia, Canada, Chile, Colombia, Great Britain, India, Iran, Jamaica, Pakistan, the Philippines, Spain, Thailand, Turkey, and the United States—and the World Health Organization. The papers and discussions focused on the migration of recent medical graduates from developing (donor) to developed (recipient) countries, who go on the basis of individual choice; without government sponsorship; and who usually have no assured appointment in their homeland upon the completion of their overseas training. It was evident that sponsored visitors present no major problem. The conference participants agreed that it is important that there should be no governmental or statutory restrictions on the international movement of doctors. However, the continued and significant loss of
Commentaire du travail de Lee YN et al., pp. 1056
Journal: Endoscopy (2014)

See also: Core biopsy needle versus standard aspiration needle for endoscopic ultrasound-guided sampling of solid pancreatic masses: a randomized parallel-group studyEndoscopy 2014; 46(12): 1056-1062DOI: 10.1055/s-0034-1377558
Lung Transplantation
Authors: John C. Baldwin
Journal: JAMA (1988)

For many years, the possibility of isolated lung transplantation for patients with end-stage pulmonary disease has been contemplated, and for the past 25 years, the procedure has been attempted clinically on a somewhat sporadic basis by skilled and dedicated investigators, without notable success.<sup>1</sup>Progress in this area has been limited principally by problems with healing of the bronchial anastomosis; by inadequacy of lung-graft preservation and the resultant "reimplantation" phenomenon; and, to a lesser extent, by the unavailability of optimal immunosuppressive agents. The remarkable success that has been achieved in heart transplantation resulted from a clinical amalgamation of technical expertise in cardiovascular surgery and the use of cardiopulmonary bypass; laboratory experience with hypothermic metabolic inhibition for graft preservation; experience with cytotoxic and immunosuppressive therapy in oncological and renal transplant work; and the establishment, through prospective clinical investigation, of valid criteria for the selection of recipients.<sup>2</sup>The establishment of combined
Metabolic Acidosis in Burns
Authors: M. J. T. Peaston
Journal: BMJ (1968)

In asthmatic subjects an imbalance between elastase and α<sub>1</sub>‐antitrypsin (α<sub>1</sub>‐PI) exists. This study aims to evaluate whether ageing <i>per se</i> affects the levels of elastase. Both young and elderly asthmatics with comparable severity and duration of disease, as well as young and elderly healthy subjects, underwent an induced sputum procedure to measure levels of elastase and α<sub>1</sub>‐PI. The percentage of sputum neutrophils and eosinophils was higher in young and elderly asthmatics than in young and elderly controls. The levels of both total and active elastase were significantly higher in young and elderly asthmatics than in young and elderly controls, and directly correlated with the percentage of neutrophils. In addition, in both young and elderly asthmatics the levels of total and active elastase were negatively correlated with forced expiratory volume in one second values, but positively correlated with the duration of the disease. This study indicates that ageing <i>per se</i> does not necessarily lead to a progressive elastase/α<sub>1</sub>‐antitrypsin imbalance in asthma, and suggests that an important variable in the development of airway remodelling in both young and elderly asthmatics is represented by the duration of the disease.
Predictors of no-show among international patients with cancer: A 4-year analysis.
Authors: Nizar Bhulani, Lianchun Xiao, Manal Hassan, Renato Lenzi
Journal: Journal of Clinical Oncology (2017)

e18302 Background: Patient no-show (NSh) for scheduled medical appointments negatively impacts quality of care, impedes optimal use of resources, has negative economic consequences secondary to missed appointments, and uncovered referral processing costs. International patients (IntlPts) present challenging financial/travel arrangements and cultural and linguistic needs. There are currently very limited data regarding numbers of IntlPts visiting the United States for medical care and no data regarding NSh rates. The purpose of this study was to quantify costs and identify IntlPts-related variables correlating with NSh to develop interventions aimed at minimizing the associated negative financial consequences. Methods: A retrospective study of IntlPts accepted and scheduled for an appointment at the International Assessment Center at MD Anderson in fiscal years 2010 – 2013 was conducted. Overall 52 variables were evaluated that included socio-demographic and clinical patient characteristics, financial responsibility, and appointment timeline. For univariate analysis, Chi-square test and Wilcoxon rank sum test were applied. For multivariate analysis, a multivariate logistic regression model was fit. The multivariate logistic model with independent covariates was used to construct a nomogram. The Time Driven Activity-Based Cost method was used to assess the cost of processing referral requests. Results: Of 1031 IntlPts scheduled, 311 (30%) were NSh. NSh was significantly associated (p &lt; 0.05) with country of origin, payer, diagnosis, referral source, disease stage, patient-delayed appointment date, number of symptoms, pain, bleeding, fatigue, dysphagia, jaundice, neurological symptoms, comorbidities, and appointment lag time. Direct operational costs were calculated using process maps and TDABC. Conclusions: These results provide the groundwork to understand operational costs and predictors of no-show of oncology IntlPts. Having knowledge of predictive factors for NSh in a new patient outpatient setting represents a necessary step towards decreasing its frequency, addressing associated costs, optimizing continuity of care, and ultimately improving outcomes and value of the provided care.
Syphilis of the Innocent. A Study of the Social Effects of Syphilis on the Family and the Community, with 152 Illustrative Cases.
Journal: JAMA (1923)

The term "innocent," as here used, applies to infections of a mate or offspring and to accidental extragenital inoculations. The work is based on the investigation of 555 families at the Boston Psychopathic Hospital, supplemented with an excellent selection of facts and figures from the literature. It is evidently designed for the use of persons interested in public welfare, and is written in language that will be intelligible to the public at large. The material is analyzed in a strikingly fair and impartial manner, with a welcome absence of exaggeration and sensationalism. This calm array of the facts in coldly scientific tabulations, with the brief exposition of illustrative cases, is far more impressive and educational than a more dramatic presentation. The issues are nowhere forced, and the authors cannot be accused of either undue pessimism or unfounded optimism. The deadly menace to innocent bystanders stands out in glaring relief, and
HOSPITAL CARS FOR TUBERCULOUS TRAVELERS.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colonial Medicine
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Table 1 Note and Results
Authors: Lauren Breithaupt, Ole Köhler-Forsberg, Liselotte Petersen
Journal: JAMA Psychiatry (2019)

Berk Ustun, MS; Lenard A. Adler, MD; Cynthia Rudin, PhD; Stephen V. Faraone, PhD; Thomas J. Spencer, MD; Patricia Berglund, MBA; Michael J. Gruber, MS; Ronald C. Kessler, PhD
Medindex.
Authors: J. B. Metcalfe
Journal: BMJ (1968)

developed rapidly in recent years.Most, if not all, regional hospital boards have com- puters, and other larger computers are avail- able on a service basis.Not £1 00m., not even £100,000, but a mere £20,0(0 would enable experimental and productive work to begin in one centre (as it is beginning in others).The educational process has already begun (as is evidenced by [his dialogue) and will, I am convinced, take less than 20 years.To achieve it we need to demonstrate much more useful results than the self-evident difference between " spells " and " persons," about which I am sure that no clinician loses much sleep.-Iam, etc.,
Endometriosis
Authors: David L. Olive, Lisa Barrie Schwartz
Journal: New England Journal of Medicine (1993)

Endometriosis is a common disorder, yet it is among the most enigmatic of gynecologic diseases. The literature on endometriosis is extensive, though often contradictory or inadequate, and reflects our frequent inability to decipher even the most fundamental aspects of common diseases. Recent studies have produced new insights into this complex disorder, however.In this review we shall critically evaluate what we know -- and do not know -- about endometriosis. Established facts will be separated from unsupported impressions, and areas of controversy will be highlighted.DefinitionEndometriosis is classically defined as the presence of endometrial glands and stroma outside the . . .
Ocular Therapy
Authors: John A. Buesseler
Journal: JAMA (1969)

This well-written and carefully edited volume contains papers presented at the Drug Symposium of the American Academy of Ophthalmology and Otolaryngology and the Association for Research in Ophthalmology meeting held in the fall of 1967. The contributing authors include many of the clinical and research authorities in ophthalmic pharmacology in the United States. As a result, the book is a reliable and up-to-date source of information on the limited number of topics included. Each of the nine chapters deals with a different aspect of drug therapy as it concerns the practicing ophthalmologist. Of particular interest to this reviewer was the excellent chapter by the editor, Irving H. Leopold, which discusses problems in the use of antibiotics in ophthalmology. His discourse on preventing postoperative infections and managing intraocular infections should interest any ophthalmologist in active surgical practice. His comments regarding antifungal agents and the toxicity of chemotherapeutic and antibiotic drugs are
Climates of the United States.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Biological Symposia. Vol. I. The Cell Theory; Mating Types and Their Interactions in the Ciliate Infusoria; Chromosome Structure . Edited by Jaques Cattell. With a foreword by Albert F. Blakeslee, Ph.D. 4°, cloth, 238 pp., with 39 illustrations and 19 tables. Lancaster, Pennsylvania: The Jaques Cattell Press, 1940. $2.50.
Journal: New England Journal of Medicine (1941)
A German Doctor at the Front. (Die Front der Ärzte)
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1960)

MEDICAL JOURNA~L norethandrolone might also be helpful.If the adipose tissue can be increased this may improve the shape of flaccid breasts.Physiotherapy involving pectoral muscle exercises is sometimes advised, but the results are not convincing.If the breasts are pendulous rather than small, plastic surgery has something to offer but would be best deferred until child-bearing is completed.Antimalarial Drugs in Rheumatoid Arthritis Q.-Is there any evidence that hydroxychlioroquine is better than chloroquine in the treatmenit of rhieumnatoid arthr)itis ?A.-The evaluation of new drugs in the treatment of rheumatoid arthritis is notoriously difficult, because of the variation in severity and activity that is part of the natural history of the disease and the lack of precise parameters of assessment.The effectiveness of the antimalarial drugs is still not certain, but reports that they exert a significant effect are appearing in increasing numbers.Retinopathy, which may lead to blindness, has been reported after the prolonged use of chloroquine,1 2 and less serious, although troublesome, side-effects are nausea, bleaching of the hair, and corneal opacities.Hydroxy- chloroquine is less toxic dose for dose than chloroquine, but there is no evidence that it is more effective.The eventual role these drugs will play in the management of rheumatoid arthritis has yet to be worked out, but they are not a substitute for adequate salicylate therapy, nor, in the case of overwhelming disease, for systemic steroid.
Abstract 3628: Comparison of CD44 expression in pancreatic cancer, pancreatic stem and normal pancreatic cells: Development of CLENs for tumor targeting and therapy using cell models
Authors: Dotun D. Adegunle, Eugene Boakye Ansah, Danny Nguyen, Kanchi Sanghvi, Drew Goodrich, Robert Campbell
Journal: Cancer Research (2019)

Abstract Purpose: The incidence of drug resistance in pancreatic cancer correlates with poor prognosis, increased disease progression and unfavorable treatment outcomes. CD44, a surface membrane proteoglycan has been identified to be directly involved in pancreatic cancer drug resistance and metastasis. As such, the aim of this research was to screen various pancreatic cells for their expression of CD44, and to begin the early design and development of cell membrane lipid-extracted nanoliposmes (CLENs) for enhanced targeting and therapy. Methods: Three pancreatic cancer cells- Panc-1, MiaPaCa 2, MS1 VEGF and a normal cell line- hTERT- were employed for this study. Stem cell, Mia PaCa-2, served as a positive control for screening purposes. Four liposome compositions were prepared using various ratios of DOPC, Chol, DPPE-PEG5000, and cellular membrane lipid-extracted (LE) was derived from target cell, Panc 1. To evaluate CD44 glycoprotein expression, cells were seeded in 48-well plates and incubated overnight. Fluorescence measurements were determined at excitation wavelength of 485/25 and emission wavelength at 528/20 nm. G44-26 monoclonal antibody was used for CLENs antibody conjugation studies. A Sephadex G-25 column was used for separation of bound and unbound antibody material, and fluorescence detection was used for cell culture analysis. Fluorescence detection was performed at excitation and emission wavelengths of 530/25 and 590/25, respectively. Results: The relative level of CD44 expression for each of the cell lines was as follows. Panc1&amp;gt;Mia PaCa-2 = hTERT&amp;gt;MS1-VEGF. There was a statistically significant difference between Panc-1 and Mia Paca 2 (P&amp;lt;0.001), between hTERT and MS1 VEGF (P&amp;lt;0.05), and between Panc-1 and hTERT (P&amp;lt;0.0001). The inclusion of Panc1-LE in combination with additional liposome components did not increase cellular uptake significantly. The conjugation of G44-26 monoclonal antibody to the liposomes increased average size of all 4 preparations. Average size for CLENs and G44-26 monoclonal antibody -CLENs increased from 140.75 ± 3.22 nm to 250.23 ± 15.31 nm. Conclusion: Future studies are required to demonstrate the effect of G44-26 monoclonal antibody liposome conjugates to further exploit the optimal expression of CD44 for pancreatic drug targeting. Citation Format: Dotun D. Adegunle, Eugene Boakye Ansah, Danny Nguyen, Kanchi Sanghvi, Drew Goodrich, Robert Campbell. Comparison of CD44 expression in pancreatic cancer, pancreatic stem and normal pancreatic cells: Development of CLENs for tumor targeting and therapy using cell models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3628.
CIVIL DEFENSE
Authors: EUGENE C. EPPINGER
Journal: Annals of Internal Medicine (1951)

Editorials1 September 1951CIVIL DEFENSEEUGENE C. EPPINGEREUGENE C. EPPINGERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-743_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOn May 7 and 8, there was held in Washington, D. C., a conference on Civil Defense under the auspices of the Civil Defense Administration with Mr. Millard Caldwell, director of this agency, as moderator. To this meeting were invited representatives of over 300 civilian organizations coming from many walks of life. Representatives of the American College of Physicians, as well as other civilian medical organizations were present.The purpose of the meeting was to alert us to grave danger of attack; to educate us in the means of preventing disastrous loss of life and property in the event of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EUGENE C. EPPINGER PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1951Volume 35, Issue 3 Page: 743-743 ePublished: 1 December 2008 Issue Published: 1 September 1951 PDF downloadLoading ...
Decline in NASH and atherosclerosis-associated oxidised phospholipids and 7-ketocholesterol in response to icosabutate therapy
Authors: David A. Fraser, Detlef Schuppan, Yong Ook Kim, Cristina Alonso, Marta Iruarrizaga-Lejarreta, Xiaoyu Wang, John Kastelein, Tore Skjaeret
Journal: Journal of Hepatology (2020)