tbuckley/cabot-search huggingface dataset:
Use of patient-controlled analgesia for management of acute pain
Authors: P. F. White
Journal: JAMA (1988)

Patient-controlled analgesia (PCA) provides improved titration of analgesic drugs, thereby minimizing individual pharmacokinetic and pharmacodynamic differences. Patient-controlled analgesia decreases patient anxiety resulting from delays in receiving pain-relieving medication and from the slow onset of analgesic action when these drugs are administered either intramuscularly or in the extradural space. With PCA therapy, patients are reportedly able to maintain a near optimal state of analgesia with minimal sedation and few side effects. The potential for overdose can be minimized if small bolus doses are used with a mandatory lockout interval between successive doses. Finally, studies of the cost-effectiveness of PCA therapy are important if this therapeutic approach is to achieve more widespread acceptance. (<i>JAMA</i>1988;259:243-247)
Weight Cycling
Authors: George L. Blackburn
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The recent National Institutes of Health (NIH) Task Force report on obesity<sup>1</sup>identifies our article<sup>2</sup>as a "widely cited study" describing the health risks of weight cycling. The task force erroneously groups our article with others cited in the meta-analysis that do not reflect weight cycling in each individual and do not use obese subjects in their study cohort. We agree with most of the conclusions of the NIH Task Force on obesity concerning weight cycling. However, we still caution about the risk of weight cycling in seriously obese patients as represented in our study but omitted in other studies cited by the task force. Even with the risk of weight cycling, significantly obese patients should attempt medically supervised long-term weight loss, normal-weight individuals should concentrate efforts to prevent weight gain, and patients must understand that successful weight loss requires permanent lifestyle changes. The meta-analysis
Alopecia in crash dieters
Authors: D. K. Goette
Journal: JAMA (1976)

Nine patients experienced profuse hair loss two to five months after starting a vigorous weight reduction program resulting in weight loss of 11.7 to 24.75 kg. Telogen counts of 25% to 50% were observed. Regrowth of hair occurred within several months. Three patients had experienced hair loss closely following a successful weight reduction program on several occasions. Rigorous caloric restriction with subsequent inadequate energy supply of the hair matrix is thought to be the cause for the precipitation of the telogen effluvium of the crash dieter. (<i>JAMA</i>235:2622-2623, 1976)
P1.03-04 Molecular Characteristics of ALK Primary Point Mutations Non-Small-Cell Lung Cancer in Chinese Patients
Authors: J. Lai, W. Wang, C. Xu, Q. Zhang, W. Zhuang, Y. Huang, Y. Zhu, Y. Chen, G. Chen, M. Fang, T. Lv, Y. Song
Journal: Journal of Thoracic Oncology (2018)
Myocardial Norepinephrine Concentration in Man: Effects of Reserpine and of Congestive Heart Failure
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Optimal blood ordering for elective surgery
Authors: J. B. Henry
Journal: JAMA (1977)

THE 21-day shelf-life of donated blood, stored at 4 to 6 C obligates blood bank directors and other physicians to manage this important resource carefully. Because frozen blood is expensive, most patients requiring hemotherapy receive units stored at 4 to 6 C. Appropriate crossmatch ordering is necessary for effective utilization of this blood. A unit of blood that has been crossmatched for a particular patient is reserved for that patient (24 to 48 hours in most institutions) and is thus unavailable for use elsewhere. Therefore, if it is not actually transfused into that patient, there is an increased likelihood of its becoming outdated. Several institutions have tried to circumvent this problem by crossmatching and reserving one unit for two or more patients simultaneously. This procedure is an expediency with inherent risks. We have studied the use of blood in elective surgery at our institution to develop guidelines for the surgical
Life Expectancy Gap Narrows
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prostate-specific antigen. Improving its ability to diagnose early prostate cancer
Authors: J. E. Oesterling
Journal: JAMA (1992)

The glycoprotein, prostate-specific antigen (PSA), was first identified in seminal plasma in 1971, and early on was referred to as gamma-seminoprotein.<sup>1</sup>Eight years later when its specificity with prostatic tissue was demonstrated, it became known as prostate-specific antigen.<sup>2</sup>Today, PSA is the the most useful tumor marker available for the diagnosis and management of prostate cancer. Indeed, the discovery of PSA represents one of the most significant advancements in the field of prostate cancer in recent times. See also pp 2191, 2215, and 2227. Currently, there is much interest in the medical community in improving our ability to detect prostate cancer before the lesion has escaped the confines of the prostate gland. This enthusiasm is based in part on the work by Jewett and associates,<sup>3</sup>who demonstrated that patients undergoing radical prostatectomy whose tumors are confined to the prostate have a survival comparable to that of age-matched
Professing ethically. On the place of ethics in defining medicine
Authors: L. R. Kass
Journal: JAMA (1983)

Medicine, despite technological advances and societal changes, remains essentially what it has always been, a profession rather than a trade, with its own ends, means, and intrinsic norms of conduct. Being a professional is an ethical matter, entailing devotion to a way of life, in the service of others and of some higher good. The medical profession is devoted to the naturally given end of health and assists the immanent powers of self-healing. It serves the needs as it treats the infirmities of the sick, sensitive to their vulnerability, shame, and exposure and mindful of the meaning of the delicate tension between bodily wholeness and necessary decay. These special characteristics imply specific and inherently medical obligations, both of omission and commission, as well as an appropriately reverential stance of the physician before his chosen profession. (<i>JAMA</i>1983;249:1305-1310)
Charcot arthropathy secondary to amyloid neuropathy
Authors: S. J. Peitzman
Journal: JAMA (1976)

Neuropathic (Charcot) ankle joints developed in a 50-year-old patient with end-stage renal disease from primary, nonfamilial amyloidosis. Sensory neuropathy in the legs had been noted three years before the onset of uremia and had progressed. Sural nerve, but not synovial biopsy specimen, showed amyloid in and around arteriolar walls by light and electron microscopy. Since Charcot joints are only rarely associated with amyloid neuropathy, it is possible that uremic neuritis, or prolonged survival by dialysis, contributed to progression of the neuropathy, allowing subsequent joint degeneration. (<i>JAMA</i>235:1345-1347, 1976)
Authors' reply
Authors: L. Hartling, R. M. Fernandes, L. Bialy, A. Milne, D. Johnson, A. Plint, T. P. Klassen, B. Vandermeer
Journal: BMJ (2011)

<h3>Objectives:</h3> To investigate seizure characteristics, types, and define the etiology of epilepsy in children aged ≤2 years using the 2017 ILAE classification. <h3>Methods:</h3> A retrospective chart review was conducted at King Khalid University Hospital, King Saud University Medical City, Riyadh, Kingdom of Saudi Arabia for children below 2 years of age diagnosed with epilepsy, and on anti-seizure medications from January 2017 – December 2018. The collected data involved detailed information on the patients’ seizure, electroclinical, neuroimaging, laboratory evaluations, and underlying etiology. <h3>Results:</h3> One- hundred and fifty patients were included in the study and classified according to etiology into: genetic (43, 28.7%), structural (41, 27.3%), metabolic (10, 6.7%), infectious (8, 5.3%), immune-mediated (1, 0.7%) and unknown (47, 31.3%) groups. The most common seizure types were generalized epilepsy, among which generalized tonic-clonic seizures occurred in 56 (37%) patients, followed by tonic seizures in 31 (21%), infantile spasm in 19 (13%), myoclonic seizures in 4 (2.7%), atonic seizures in 6 (4%), and focal seizures in 33 (22%) patients. Global developmental delay and abnormalities in both neurologic exam and neuroimaging were more common in the structural and genetic groups. Electroencephalography was abnormal in 82 (55%) patients, including the majority of the structural group (26, 63.4%). <h3>Conclusion:</h3> The etiology of epilepsy in this cohort remains undetermined (unknown) in a large proportion of cases, followed by genetic and structural causes. This result added to the published international data about epilepsy in the first 2-years of life.
THE PATHOLOGY OF NEURITIS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Defense of a Department of Geriatrics
Authors: Christine K. Cassel
Journal: Annals of Internal Medicine (2001)

Letters3 July 2001In Defense of a Department of GeriatricsChristine K. Cassel, MDChristine K. Cassel, MDMount Sinai Medical Center; New York, NY 10029 (Cassel)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-1-200107030-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Gilson asserts that geriatric medicine has always been subsumed as a major aspect of internal medicine. Although internists see an increasingly large number of elderly patients, unfortunately that in itself does not mean that most internists are well trained in the content and principles of geriatric medicine. Early leaders in the field of geriatrics, such as eminent internist Paul Beeson, pointed out that the specialty of geriatric medicine as recognized in other developed countries around the world includes a significant body of knowledge about aging and age-related syndromes, as well as a different approach to the patient ... Author, Article, and Disclosure InformationAuthors: Christine K. Cassel, MDAffiliations: Mount Sinai Medical Center; New York, NY 10029 (Cassel) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIn Defense of a Department of Geriatrics Christine K. Cassel In Defense of a Department of Geriatrics Saul B. Gilson Metrics 3 July 2001Volume 135, Issue 1Page: 62KeywordsAgingElderlyGeriatricsMedical educationPatientsResidency ePublished: 3 July 2001 Issue Published: 3 July 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Routine prenatal and gynecologic care in prepaid group practice
Authors: M. J. Hughey
Journal: JAMA (1986)

A survey of routine prenatal and gynecologic care provided by 26 prepaid medical groups to 1 673 895 members and 25 724 obstetrical deliveries per year showed that, in actual clinical practice, there is considerable disagreement over what should constitute routine care. The fact that many providers of care do not adhere to routines recommended by textbooks, professional groups, or legal precedent leads to diversity of routine care. (<i>JAMA</i>1986;256:1775-1777)
Changes in blood rheology produced by exercise
Authors: E. Ernst
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Dalessio's<sup>1</sup>recent editorial about Maurice Ravel effectively portrays the tragic final years of that influential 20th-century composer. However, I must take exception to his description of Ravel's amusia. I base these comments on the published testimony of Ravel's neurologist, Theophile Alajouanine, whose article, "Aphasia and Artistic Realization,"<sup>2</sup>should be read by any physician with an interest in the creative arts. Assisted by one of Ravel's favored pupils and by a neurology colleague who was also an accomplished musician, Alajouanine made a detailed study of his celebrated patient's musical abilities. What he found was that Ravel's capacity to appreciate music and evaluate it critically was unimpaired. For example, when some of his own piano music was played for him with even minor errors in rhythm or melody, he could immediately identify the errors, and, in his halting speech, he could specify what was incorrect. Also, his
Abstract 40: A Prospective Study on the Association of Kawasaki Disease and Mycoplasma pneumoniae Infection
Authors: Jong-Woon Choi, Min-Ah Cha
Journal: Circulation (2015)

Objective: The etiology of Kawasaki disease(KD) remains unknown, and several infectious agents have been proposed as the etiology of KD. There have been some studies, stating that KD and Mycoplasma pneumoniae(M. pneumoniae) infection are linked. So authors performed a prospective study to elucidate whether there is association between KD and M. pneumoniae infection. Subjects and Methods: Subjects are 36 patients with KD who admitted to Bundang Jesaeng General Hospital from January 2013 through August 2014. Patients were assigned to the M. pneumoniae group and the control group according to anti-mycoplasmal IgM antibody(AMA) titers. Clinical features, laboratory findings, courses and outcomes were compared between two groups. Results: AMA were positive or indeterminate in 11 patients(30.6%; M. pneumoniae group) and were negative in 25 patients(69.4%; control group). There were no significant differences between two groups in age and sex distributions, duration of fever, laboratory findings(WBC counts, ESR, CRP, AST, ALT, bilirubin), chest X-ray findings, and echocardiographic abnormalities(coronary arterial lesion, pericardial effusion, valvular regurgitation, LV dysfunction). AMA titers were rechecked in 6 patients, of whom 5(83.3%) showed decreased titers and 1(16.7%) showed an increased titer. All of patients were treated successfully with intravenous immunoglobulin and oral aspirin. Conclusion: Although AMA was detected in some patients with KD, it did not affect clinical features, laboratory findings, courses and outcomes of KD. In most cases AMA titers were decreased in the second examinations, so authors think that M. pneumoniae infection was a previous infection rather than a concurrent infection in some patients with KD and it did not act as a causative agent of KD.
The Surgeon General's warnings in outdoor cigarette advertising. Are they readable?
Authors: R. M. Davis
Journal: JAMA (1989)

Outdoor advertising media represent a major vehicle by which cigarette companies promote their products. We investigated the readability of the Surgeon General's warning in cigarette advertisements (ads) in two outdoor media: billboards and taxicab ads. In an experiment in metropolitan Atlanta under typical driving conditions, observers were able to read the entire health warning on 18 (46%) of 39 street billboards but on only two (5%) of 39 highway billboards. In contrast, the content of the ads (ie, brand name, other wording, and notable imagery) could be recognized under the same conditions on more than 95% of the billboards. In a similar study of 100 taxicab cigarette ads in New York City, observers were unable to read the health warning in any of the ads but were able to identify the brand name in all ads and notable imagery in 95% of the ads. Significant differences between the readability of the warning and identification of the advertising content persisted even when partially read warnings were considered to have been read. We conclude that the Surgeon General's warning is not readable in its current form in the vast majority of billboard and taxicab ads. Factors contributing to unreadability include the small size of the letters, the excessive length of the warnings, the distance between the viewers and the ads, and movement between the viewers and the ads. (<i>JAMA</i>1989;261:90-94)
Data Presentation Error in Results Section
Authors: Robert Gale, Hui-Sheng Ai, Mei Guo, Nelson Chao
Journal: JAMA Oncology (2018)

Heather Hampel, MS, CGC; Rachel Pearlman, MS, CGC; Mallory Beightol, BS, MB(ASCP); Weiqiang Zhao, MD, PhD; Daniel Jones, MD, PhD; Wendy L. Frankel, MD, PhD; Paul J. Goodfellow, PhD; Ahmet Yilmaz, PhD; Kristin Miller, BS; Jason Bacher, BA; Angela Jacobson, MS, CGC; Electra Paskett, PhD; Peter G. Shields, MD; Richard M. Goldberg, MD; Albert de la Chapelle, MD, PhD; Brian H. Shirts, MD, PhD; Colin C. Pritchard, MD, PhD; for the Ohio Colorectal Cancer Prevention Initiative Study Group
Ophthalmology
Authors: Terrence P. O'Brien
Journal: JAMA (1993)

The concept of modifying the shape of the cornea to induce changes in the refractive state of the eye is not new, but recent reports of improved success with newer procedures and technologies have generated increased enthusiasm among ophthalmologists and patients anxious to eliminate the need for glasses or contact lenses. However, amid the new wave of excitement persist concerns among many ophthalmologists about predictable efficacy and consistent safety of some refractive surgical procedures. It has been four decades since development of a surgical approach to correct myopia by creating anterior and posterior radial incisions in the cornea.<sup>1</sup>Although initial procedures successfully reduced the amount of myopia, nearly 75% of the eyes developed corneal edema in 10 to 20 years, presumably caused by damage to the corneal endothelium.<sup>2</sup>Modifications of the early Japanese technique were followed by a shift to anterior radial incisions only, as popularized by the
Circulation Research Thematic Synopsis
Journal: Circulation Research (2012)

The goal of Thematic Synopses is to provide our readers with a concise but comprehensive overview of the work published in Circulation Research, which we hope will keep our readers abreast of recent scientific discoveries and facilitate discussion, interpretation, and integration of the findings.These collections of articles are organized thematically and the papers listed in chronological order, beginning with the most recent ones.In each synopsis, the top downloaded original research articles (normalized to time since publication) are highlighted in yellow.Review articles are also included with titles highlighted in blue and the summary of each is provided.Instead of using abstracts, we have elected to publish the Novelty and Significance section of each article, which we believe provides a clear précis of the salient findings and their implications in a language that is easily understandable by the non-initiated.This will enable readers who are not experts in a particular field to grasp the significance and impact of work performed in other fields.It is our hope and expectation that Thematic Synopses will help readers to gain a broader awareness and a deeper understanding of the status of research across the vast landscape of cardiovascular research.
Reduction of young driver crashes in a controlled pilot study: two-year follow-up in one Michigan high school
Authors: S. H. Schuman
Journal: JAMA (1971)

Previous research indicates a high accident rate for young male drivers aged 18 to 20 years. In a pilot study, high-school seniors in a countermeasure program achieved a 50% reduction in their accident rate compared to a control group during a two-year follow-up period. A similar reduction occurred in the accident rate per 100 drivers weighted by severity of crashes among the countermeasure drivers. The results are not statistically significant, but show promise for current trials in large populations. The countermeasure program had two components, small group discussions weekly for seven weeks, and personalized driving letters sent to pilot program seniors at six-month intervals following the discussion workshop.
A MODIFICATION OF THE CLIP-FLAP TECHNIQUE: THE CLIP-BAND-FLAP TECHNIQUE
Authors: A Parra-Blanco, M Fraile-López
Journal: Endoscopy (2020)

The clip-flap technique was described to facilitate the creation of a mucosal flap in colorectal ESD. Its main utility is at the beginning of ESD, facilitating the submucosal access. The clip-band technique has been used in gastric and colorectal ESD. The second clip is used to clamp the band, and it is attached on to the normal mucosa distal or opposite to the resection site. This clip is only applied after having completed the circumferential incision. Here we present the clip-band-flap technique for the resection of LST-NG pseudodepressed lesion JNET2B with the two stage traction applied in a sequential fashion.