tbuckley/cabot-search huggingface dataset:
Thyroid Storm
Authors: Drummond Rennie
Journal: JAMA (1997)

In this issue of THE JOURNAL, we are publishing a report<sup>1</sup>of work that started 9 years ago, was concluded in December 1990, and the data from which were published in another journal in July 1995. Given that we at<i>JAMA</i>like to keep up-to-date and that we try never to republish what others have already put in print, the reader might well ask what is going on. The story necessary to answer this question provides a cautionary tale that illustrates the sharply differing views of research taken by the university researcher and the company sponsoring that research, if the company's product is at stake. At a time when an increasing proportion of research funding is provided by private companies,<sup>2</sup>the story holds lessons for both, as well as for university faculties, administrators, regulatory agencies, and for physicians who prescribe on the basis of evidence. See also pp
Abstract 1407: Interferon Regulatory Factor-9 (irf-9) Mediates Short Term Host Protection, But Promotes Long Term Immune Injury In Evolution Of Myocarditis Leading To Dilated Cardiomyopathy
Authors: Michael Konviser, Youan Liu, Manyin Chen, Yu Shi, Mei Sun, Anthony Gramolini, Eleanor Fish, Anne Opavsky, Peter Liu
Journal: Circulation (2007)

INTRODUCTION: Evolution of viral myocarditis to dilated cardiomyopathy (DCM) represents a delicate balance between host innate immunity and T-cell acquired immunity. IRF-9 is a key member of a transcription factor family that regulates type I interferon (IFN) production, critical for innate antiviral protection. However, the influence of innate immunity in general and IRF-9 in particular on acquired immunity and DCM is unknown. HYPOTHESIS: IRF-9 signaling provides immediate host protection through interferon production, but stimulates acquired immunity leading to DCM in a coxsackievirus murine myocarditis model. METHODS: Interferon-regulatory factor 9 (IRF-9) homozygous knockout mice were generated, and show impaired type I interferon production. Wild-type (WT, n=51) and IRF-9 −/− (n=124) littermates were inoculated with 10^2 p.f.u. of coxsackievirus B3 as previously described. Survival, viral titers, cardiac hypertrophy, inflammation and fibrosis were evaluated on days 0, 4, 7, 10, 14, 28 and 42. Splenocyte subpopulations were cell sorted and quantitated by FACS. RESULTS: IRF9−/− mice showed dramatically increased mortality compared to the wild-type littermates (0% WT vs 72% IRF-9 −/− on day 14, P&lt;0.0001). On day 42, there was less cardiac hypertrophy and inflammation in IRF-9 −/− mice compared to WT controls (p&lt;0.05). There was no difference in fibrosis. The mature T-lymphocyte population, defined as CD4 or CD8 single positive, was statistically identical in the two populations up until and including day 28 post-infection. However on day 42 there was a dramatic increase in the number of cytotoxic and helper T-Cells in the wild-type mice that was not observed in the IRF-9 −/− spleens (p&lt;0.05). CONCLUSIONS: These data suggest a novel dual role of IRF-9 in not only regulating interferon in acute stage of viral infection in myocarditis, but also late acquired immunity activation, including CD4/8 populations, contributing to the development of chronic cardiomyopathy.
1019O Phase I studies of Sym021, an anti-PD-1 antibody, alone and in combination with Sym022 (anti-LAG-3) or Sym023 (anti-TIM-3)
Authors: N. Lakhani, A. Spreafico, A.W. Tolcher, J. Rodon, F. Janku, S.R. Chandana, M. Oliva, M. Sharma, R.M. Abdul-Karim, U.H. Hansen, L. Hansen, N.J.Ø. Skartved, T.T. Poulsen, R.P. Nadal, J. Lantto, D.L. Wood, P.I. Nadler, L.L. Siu
Journal: Annals of Oncology (2020)
Abstract SY20-02: The SIRT3-MnSOD-Ac axis in carcinogenesis and tumor resistance
Authors: David R. Gius, Yueming Zhu
Journal: Cancer Research (2019)

Abstract ABSTRACT The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity, and its oncogenic and/or physiological significance, is unclear. Here we show that expression of the MnSOD-K68 acetylation (Ac) mimic mutant (MnSODK68Q) transformed wild-type primary mouse embryonic fibroblasts (pMEFs) when co-infected with either c-Myc or Ras, as measured by in vitro transformation assays and xenograft formation. Immortalized MnSOD-/- mouse embryonic fibroblasts (MEFs) infected with lenti-MnSODK68Q also exhibited an in vitro transformation permissive phenotype. In addition, MCF7 and T47D cells expressing MnSODK68Q demonstrated increased in vitro and xenograft oncogenic properties. These findings collectively identify MnSODK68Q as a tumor promoter. MCF7, T47D, and MnSOD-/- cells expressing MnSODK68Q displayed a monomeric form of MnSOD, distinct from the well-established homotetramer, and MnSOD-K68-Ac functions as a peroxidase, determined using a bacterial system for site-specific incorporation of N-(ε)-acetyl-l-lysine. Finally, tamoxifen resistant MCF7 and T47D cells, and a subgroup of human breast malignancies, displayed a MnSOD-K68-Ac signature. Citation Format: David R. Gius, Yueming Zhu. The SIRT3-MnSOD-Ac axis in carcinogenesis and tumor resistance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr SY20-02.
Licensure of Varicella Virus Vaccine, Live
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Another Side of the Coin
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myelography-Reply
Authors: Solomon Batnitzky
Journal: JAMA (1977)

Progressive pain in the back or lower extremities was the striking clinical feature in our three cases of intraspinal epidermoid tumors. In reviewing the literature, this has also been a prominent clinical presentation. We did not advocate that myelography should be performed in every patient complaining of back or lower extremity pain who has had previous lumbar punctures. We used the word "consider," which is defined by<i>Webster's Unabridged Third New International Dictionary of the English Language</i>(1961) as "to think about with a degree of care or caution." Rather, we implied that the association of a previous lumbar puncture and lower extremity or back pain and the possible development of an intraspinal epidermoid tumor should be an added consideration or factor in deciding whether or not a myelogram should be performed. Obviously, the total clinical picture has to be taken into consideration in making the final decision
Prospective multicenter study of sofosbuvir-velpatasvir (SOF/VEL) in hepatitis C virus (HCV) negative liver (LT) and kidney transplant (KT) recipients receiving HCV viremic donors
Authors: Raymond Rubin, David Victor, James Burton, Elizabeth Verna, James F. Trotter, Claus Niemann, Constance Mobley, Norah Terrault
Journal: Journal of Hepatology (2020)
Diseases of the Thyroid Gland.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gulstonian Lectures: On Diabetes and Saccharine Conditions of the Urine
Authors: A. B. Garrod
Journal: BMJ (1857)

there had not been a dejection from the bowels for three days.Effervescing medicine with hydrocyanic acid, and a castor oil draught, were prescribed; and water ices, and brandy occasionally taken.July 13th.The exhaustion had increased.She threw herself about with her arms extended.The sickness was greater.
Hyponatremia induced by a combination of amiloride and hydrochlorothiazide
Authors: P. H. Strykers
Journal: JAMA (1984)

HYPONATREMIA developing after conventional diuretic therapy has been well documented. Recently, some cases of hyponatremia developing after the administration of an amiloride-hydrochlorothiazide combination, as early as six days after the onset of treatment, have been reported.<sup>1-3</sup>This article reports a case of severe hyponatremia developing after two doses of an amiloride hydrochloride, 5 mg, and hydrochlorothiazide, 50 mg, combination. <h3>Report of a Case</h3> A 78-year-old, generally healthy woman had been treated with hydrochlorothiazide, 50 mg daily, and potassium supplements for hypertension since 1975. In 1982, propranolol hydrochloride, 20 mg twice daily, was added to her regimen. Her serum sodium level has ranged from 132 to 133 mEq/L, with normal potassium levels. On July 12, 1983, to simplify her regimen, hydrochlorothiazide and potassium chloride were changed to one tablet daily of an amiloride hydrochloride, 5 mg, and hydrochlorothiazide, 50 mg, combination. A chemistry screen on the same day revealed a sodium
S. Weir Mitchell and the ghosts
Authors: W. K. Beatty
Journal: JAMA (1972)

S. Weir Mitchell was born into an old and respected Philadelphia family on Feb 15, 1829. In such well-ordered surroundings ghosts should have had no place, but during Mitchell's long and active life they kept turning up frequently and in many different guises. A religious ghost gave him such a fright when he was a child that he could recall it vividly over half a century later and turn it into a dramatic incident in one of his best novels. Ghost stories occurred in several of his literary efforts, and one of his short stories, "A Ghost of Glory," combines the supernatural with Mitchell's patriotism and his abiding interest in ships. His most unusual ghosts were undoubtedly those of "phantom limbs," the sensations of lost arms and legs that come back to haunt the amputees years after the amputation. S. Weir Mitchell had been given the name "Silas" but disliked
Ultrasonic determination of pericardial effusion
Authors: B. B. Goldberg
Journal: JAMA (1967)

The accuracy of ultrasonic diagnosis of pericardial effusion can be improved by adoption of a standard technique so that results are reproducible. Knowledge of anatomic landmarks is important for both the proper positioning of the transducer and the prevention of errors in diagnosis. The characteristic posterior echo complex that is recorded in the presence of pericardial effusion arises from the pericardial structures in the vicinity of the left atrioventricular groove. Anterior echo complexes can be obtained in approximately 50% of patients with pericardial effusion. B-mode ultrasound can be used for the detection of cardiac tamponade and the demonstration of changes following pericardiocentesis. Pulmonary and pleural lesions such as atelectasis, consolidation, and basilar effusion cause false echo complexes and it is important that these be recognized.
The Abbey of Evolayne
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Etiologic Models of Rheumatoid Arthritis
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HEREDITY AND OBESITY
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fortune
Authors: Susan Palwick
Journal: Annals of Internal Medicine (2011)

Ad Libitum15 March 2011FortuneSusan PalwickSusan PalwickFrom Reno, NV 89557.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-6-201103150-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The fortuneteller said your husband woulddie early. You don't tell us how she knew.Brown tea-leaves clumped, insoluble, the bloodclot to the heart? Your palm's fine creases toounbending, like this flat asystole?Glass sphere as cloudy as his eyes? Or cards?The Three of Medic, Queen of Nurse, MDland upside down, their comfort cardboard wordsas stiff and awkward as his cooling limbs.“I'm sorry for your loss.” They go. I stay,the chaplain, with a tech. We plunder himfor you, find wallet bulging bills, gold chainsat neck and wrist, his Rolex, elegant:a fortune, yes, but not the one you want.Susan PalwickReno, NV 89557 Author, Article, and Disclosure InformationAffiliations: From Reno, NV 89557.Current Author Address: Susan Palwick, University of Nevada, Reno, Reno, NV 89557. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 2011Volume 154, Issue 6Page: 412KeywordsHeartNursesThrombosis ePublished: 15 March 2011 Issue Published: 15 March 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Chemical Agents and the Immune Response
Authors: Michael I. Luster, Gary J. Rosenthal
Journal: Environmental Health Perspectives (1993)

Our desire to understand the potential adverse human health effects of environmental chemical exposure has coincided with an increased understanding of the immune system and an appreciation of its complex regulatory network. This has spawned a broad interest in the area of immunotoxicology within the scientific community as well as certain concerns in the public sector regarding chemical-induced hypersensitivity and immunosuppression. The incidence of alleged human sensitization to chemicals has increased, in part, due to the fact that chemical companies are moving to larger and/or different markets. It has been estimated that 35 million Americans suffer from allergic disease, of which 2-5% are from occupational exposure. Although there is not yet a clear understanding of dose-response relationships or disease predisposition, there are many well-defined examples (isocyanates, anhydrides) of chemical sensitizers in humans and experimental animals. Evidence that chemicals suppress immune responses in humans is considerably less well established, although there is a public perception that chemicals generally cause immunosuppression. This perception has been fueled by highly publicized legal cases and scientific controversies within the academic and industrial communities. As a consequence of these public and scientific concerns, many of the regulatory agencies are developing immunotoxicity testing guidelines. At the present, however, there are limitations on adequate human methodology and data that allow the extrapolation of animal data to assess human risk. The potential for human immunosuppression remains of concern, however, because of a large database generated from animal studies that demonstrates immunosuppression as well as reports of immunosuppression in humans inadvertently (e.g., halogenated aromatic hydrocarbons) or occupationally (asbestos, benzene) exposed to xenobiotics.(ABSTRACT TRUNCATED AT 250 WORDS)
Otosclerosis Associated With Osteopoikilosis
Authors: Robert G. Adler
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Osteopoikilosis is a rare bone dysplasia thought to be inherited by an autosomal dominant mechanism.<sup>1</sup>It is characterized by. numerous spheroid nodules in the spongiosa of the metaphysis and epiphysis. The bones involved most often are the long bones and the small bones of the hands, feet, and pelvis. Osteopoikilosis usually is found incidentally on roentgenography. Its pattern is pathognomonic (ie, polka-dot or spotted bones). Patients with osteopoikilosis have been found to have an increased incidence of dermatofibrosis lenticularis disseminata (localized areas of elastic fiber hyperplasia of the skin). There have been reports of association with keloid formation,<sup>2</sup>dwarfism,<sup>1</sup>and dystocia.<sup>2</sup> We describe here cases of a daughter and mother with both osteopoikilosis and otosclerosis, as well as two cousins of the proband with otosclerosis. <h3>Report of Cases.—Case 1.—</h3> A 21-year-old woman went to her podiatrist for foot pain and was
Herpes Zoster
Authors: S. H. Sklar, J. S. Wigand
Journal: British Journal of Dermatology (1981)

Journal Article Herpes Zoster Get access S. H. Sklar, S. H. Sklar Englewood Hospital, Englewood, N.J. 07631, USA Search for other works by this author on: Oxford Academic Google Scholar J. S. Wigand J. S. Wigand Englewood Hospital, Englewood, N.J. 07631, USA Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 104, Issue 3, 1 March 1981, Pages 351–352, https://doi.org/10.1111/j.1365-2133.1981.tb00964.x Published: 01 March 1981