tbuckley/cabot-search huggingface dataset:
A genomic classifier to identify men with adverse pathology post radical prostatectomy who benefit from adjuvant radiation therapy.
Authors: Robert Benjamin Den, Kasra Yousefi, Edouard John Trabulsi, Firas Abdollah, Voleak Choeurng, Felix Yi-Chung Feng, Adam Dicker, Costas D. Lallas, Leonard G. Gomella, Elai Davicioni, R. Jeffrey Karnes
Journal: Journal of Clinical Oncology (2015)

168 Background: The optimal timing of postoperative radiotherapy following radical prostatectomy (post-RP RT) is unclear. We hypothesized that a genomic classifier (GC) would provide prognostic and predictive insight into the development of clinical metastases in men receiving post-RP RT and inform decision-making. Methods: GC scores were calculated from 188 patients with pT3 or margin positive PCa, who received post-RP RT at Thomas Jefferson University and Mayo Clinic, between 1990 and 2009. The primary endpoint was clinical metastasis. Prognostic accuracy of the models were tested using c-index and decision curve analysis. Cox regression tested the relationship between GC and metastasis. Results: The cumulative incidence of metastasis at 5 years post-RT was 0%, 9%, and 29% for low, average, and high GC scores, respectively (p=0.002). In multivariable analysis, GC and pre-RP PSA were independent predictors of metastasis (both p&lt;0.01). Within the low GC score (&lt;0.4), there were no differences in the cumulative incidence of metastasis comparing those who received adjuvant or salvage RT (p=0.79). However, for patients with higher GC scores (≥0.4) cumulative incidence of metastasis at 5-year was 6% vs. 23% for patients treated with adjuvant vs. salvage RT (p&lt;0.01). Conclusions: In patients treated with post-RP RT, GC is prognostic for the development of clinical metastasis beyond routine clinical/pathologic features. Though preliminary, patients with low GC are best treated with salvage radiation, while those with high GC benefit from adjuvant therapy. These findings provide the first rationale selection of timing of post-RP RT.
Incidence of Diagnosed Sarcoidosis in Louisiana
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Age as a Function in the Development of Sodium-Related Hypertension
Authors: Robert W. Tuthill, Edward J. Calabrese
Journal: Environmental Health Perspectives (1979)

The populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. Hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by the same factors. A possible common denominator in the development of any chronic elevation of blood pressure is the need for the kidney to increase urine volume to promote sodium excretion and, thereby, prevent a chronically expanded extracellular fluid (ECF). Hypertension may be viewed as a maladaptation of the body in its attempt to maintain homeostasis of the ECF. Man evolved under conditions of relative scarcity of salt and even now can maintain normal body function with an intake of less than 2 g/day. The high risk person appears to have a hereditary predisposition to a rise in blood pressure in the presence of a high sodium (NaCl) intake. Actually, the degree of rise in blood pressure may be an interaction between the amount of genetic predisposition and the level of sodium and its relation to potassium intake. Recent work in two Massachusetts communities supports this interpretation and suggests that differences in blood pressure distribution may increase with age between a higher and lower sodium community.
Effect of Nitrite Ion on Intact Human Erythrocytes
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic Electromyography
Authors: J. Goodgold
Journal: JAMA (1967)

<h3>To the Editor:—</h3> In the paper entitled "Diagnostic Electromyography" (<b>199</b>:727, 1967), I wish to call attention to a few confusing and controversial features. The statement that normal muscle at rest presents no electrical potentials should be qualified. There is a normal variety of spontaneous discharges which are frequently encountered when the electrode is inserted within the zone of innervation of a muscle. The potentials are identifiable and in their several forms are referred to as end-plate activity. The features of the electrical potential observed on the cathode-ray oscilloscope screen are a function of the size and number of subunits of a given motor unit which are detected within the restricted area of recording. Since more than one subunit may be involved, the waveform may be altered so that a quadriphasic potential is not to be considered abnormal. It is invalid to say that a normal potential "will have no
Early detection of prostate cancer by routine screening
Authors: G. W. Chodak
Journal: JAMA (1984)

In an attempt to detect prostate cancer when the disease was still localized, a free screening clinic was established for men over the age of 45 years. Digital rectal examinations were performed for 811 men. Prostate biopsy was recommended to 43 in whom abnormalities were found by digital rectal examination; only 38 complied. Prostate cancer was detected in 11 men. The patients with cancer ranged in age from 60 to 79 years, with the highest incidence of cancer in the group aged 70 to 79 years. The overall incidence in men between 51 and 80 years old was 1.7%. Staging evaluation revealed that none of the patients with prostate cancer had metastases to the bone or elevated serum acid phosphatase levels. Five men (45%) were found by clinical or pathological methods to have stage B disease. Two others (18%) showed radiographic evidence of lymph node metastases (stage D1). The cost of detecting each cancerous prostate tumor was approximately $6,300. Routine screening can be a cost-effective method for diagnosing prostate cancer in patients with less extensive disease. The ability of early detection to prolong survival of patients with this disease will require further investigation. (<i>JAMA</i>1984;252:3261-3264)
Vascular Surgery, New York
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Violence Education in Family Practice Residency Programs—United States, 1989
Journal: JAMA (1991)

In the United States, violence is a well-documented public health problem (1-3), and physicians have been urged to help reduce the impact of this problem (4). To assess efforts to educate family practice physicians about violence, in 1989, an investigator in a family practice residency program conducted a national survey of all family practice residency directors. The survey assessed the beliefs of residency directors regarding specific types of violence and the role of family practice residency programs in educating physicians about this problem. This report summarizes results of the survey (5).
Exfoliative cytology of the upper gastrointestinal tract
Authors: D. W. Taebel
Journal: JAMA (1967)

The utilization of exfoliative cytology as a diagnostic tool is dependent in part upon the decreased adherence of malignant cells to each other, and to well-defined cytostructure indications of malignancy. It was applied as a method to diagnose gastrointestinal cancer as early as 1858 by Beale, and reemphasized by Marini in 1909, who first employed gastric lavage. Because of the development of x-ray and endoscopic techniques, the cytological method was not used extensively until 1940, with the advent of special staining techniques by Papanicolaou. Since that time, the value and accuracy of exfoliative cytology in evaluating the gastrointestinal tract have been emphasized repeatedly, particularly by Rubin, Raskin, and others from this laboratory.<sup>1-4</sup>In addition, the reproducibility of these results and the reliability of the procedure are evident from the accuracy rates of similar magnitude emanating from other laboratories.<sup>5</sup> <h3>Basic Concepts</h3> There are three categories of cytostructural changes which
Symptom Severity in Advanced Cancer, Assessed in Two Ethnic Groups by Interviews with Bereaved Family Members and Friends
Authors: Jonathan Koffman, Irene J Higginson, Nora Donaldson
Journal: Journal of the Royal Society of Medicine (2003)

Little research has been reported on the experience of cancer among minority ethnic communities in the UK. As part of a wider survey in inner London we interviewed bereaved family members or close friends of 34 first-generation black Caribbeans and of 35 UK-born white patients about symptoms and symptom control in the year before death with cancer. They were drawn from population samples in which the response rates were equal at about 46%. Symptoms in the two ethnic groups were similar. However, multivariate logistic regression indicated greater symptom-related distress in black Caribbeans for appetite loss, pain, dry mouth, vomiting and nausea, and mental confusion. Respondents were also more likely to say, in relation to black Caribbean patients, that general practitioners (though not hospital doctors) could have tried harder to manage symptoms. The findings suggest a need for better assessment and management of cancer symptoms in first-generation Caribbean Londoners, guided by a deeper understanding of cultural influences on their responses to advanced illness.
Abdominal ultrasound findings mimicking hematological malignancies in a study of 218 gaucher patients
Authors: Orit Neudorfer, Irith Hadas‐Halpern, Deborah Elstein, Ayala Abrahamov, Ari Zimran
Journal: American Journal of Hematology (1997)

Gaucher disease, the most prevalent sphingolipidosis, generally presents with splenomegaly, anemia, and thrombocytopenia. Hence, hematologists are often the specialists involved in diagnosis and management of these patients. We present ultrasonographic characteristics in a cohort of 218 consecutive Gaucher patients evaluated in our clinic during the past 5 years. Our data emphasize the high prevalence of lesions mimicking hematological malignancies in Gaucher disease. One fifth of 184 non-splenectomized patients had intra-splenic lesions, 6% of all patients had similar lesions in the liver, and 32% of 34 splenectomized patients (but none of the other patients) had marked retroperitoneal or peri-portal lymphadenopathy. The presence of splenic lesions correlated with age and splenic size, but not with extent of bone involvement or genotype. Interestingly, they were not affected by reduction in splenomegaly following enzyme replacement therapy. The importance of these findings is to include Gaucher disease in the differential diagnosis of splenic or hepatic lesions, especially in Ashkenazi Jews. Conversely, they are relevant for follow-up of all Gaucher patients, including asymptomatic individuals, because of the reported increased incidence of hematological malignancies in Gaucher disease. Am. J. Hematol. 55:28-34, 1997. © 1997 Wiley-Liss, Inc.
Satellite Videoconference on Hepatitis C
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ursodiol Is Associated with Fewer Precancerous Abnormalities of the Colon in Certain Patients with Ulcerative Colitis
Journal: Annals of Internal Medicine (2001)

Summaries for Patients16 January 2001Ursodiol Is Associated with Fewer Precancerous Abnormalities of the Colon in Certain Patients with Ulcerative ColitisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-2-200101160-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Ulcerative colitis (UC) is a disease in which chronic inflammation of the colon leads to diarrhea, bleeding into the stool, abdominal pain, difficulties with nutrition, and an increased risk for colon cancer. Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tract, the system that brings bile from the liver to the gut. Approximately 2% to 4% of patients with UC also have PSC. Nearly half of patients with both UC and PSC will develop colon cancer or precancerous changes of the colon (dysplasia) within 25 ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Ursodiol Use Is Associated with Lower Prevalence of Colonic Neoplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis.” It is in the 16 January 2001 issue of Annals of Internal Medicine (volume 134, pages 89-95). The authors are BY Tung, MJ Emond, RC Haggitt, MP Bronner, MB Kimmey, KV Kowdley, and TA Brentnall.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUrsodiol Use Is Associated with Lower Prevalence of Colonic Neoplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis Bruce Y. Tung , Mary J. Emond , Rodger C. Haggitt , Mary P. Bronner , Michael B. Kimmey , Kris V. Kowdley , and Teresa A. Brentnall Metrics 16 January 2001Volume 134, Issue 2Page: I-69KeywordsAcidsBileBiliary systemCancer preventionColonColorectal cancerLiverLiver diseasesPrimary sclerosing cholangitisUlcerative colitis ePublished: 16 January 2001 Issue Published: 16 January 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE NATURE AND THE CAUSE OF PUERPERAL ECLAMPSIA.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdelkefi A, Ladeb S, Torjman L, Ben Othman T, Lakhal A, Ben Romdhane N, El Omri H, Elloumi M, Belaaj H, Jeddi R, Aissaouï L, Ksouri H, Ben Hassen A, Msadek F, Saad A, Hsaïri M, Boukef K, Amouri A, Louzir H, Dellagi K, Ben Abdeladhim A, on behalf of the Tunisian Multiple Myeloma Study Group. Single autologous stem-cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a multicenter randomized …
Journal: Blood (2009)
Desert Storm veterans now may donate blood; others call for discussion of donor tests
Authors: P. Gunby
Journal: JAMA (1993)

PERSIAN GULF veterans are no longer banned from donating blood, as of this month. Fear that<i>Leishmania tropica</i>, a parasite transmitted by sand flea (<i>Phlebotomus papatasi</i>) bites, could be spread through transfusions prompted the November 12,1991, ban. Cutaneous leishmaniasis remained a concern during large-scale 1990 and 1991 US military operations in Saudi Arabia, Kuwait, and Iraq (<i>JAMA</i>. 1991;265:435,439-440) and now is listed by the US Army Medical Research and Development Command as a possible health threat to US troops in Somalia. <h3>No Transfusion Transmission</h3> However, "since there has been no documented case of transfusion-transmitted<i>L tropica</i>[during the nearly 14 months of the ban], and after a careful review of current information, American blood banks are being advised to drop the ban on blood donations from those individuals who were in the Persian Gulf during Operation Desert Shield/Storm," says Arthur J. Silvergleid, MD, president, American Association of Blood Banks. The
The hourly rate of urinary amylase excretion, serum amylase, and serum lipase: Part II Patients with gastrointestinal and pancreatic disorders
Journal: Gut (1971)

Part II Patients with gastrointestinal and pancreatic disordersAbstract Gastrointestinal disease other than hepatobiliary and pancreatic disorders was associated with hourly rates of urinary amylase excretion above the limits of normal for control subjects (88 IU/hour compared with 69 IU/hour). In hepatobiliary disease, excretion rates of more than 88 but usually less than 190 IU/hour were sometimes found. Whilst rates of urinary amylase excretion were not helpful in the diagnosis of chronic pancreatitis or carcinoma of the pancreas, levels above 190 IU/hour were found in acute pancreatitis at a time when the serum levels were also diagnostic. After the acute episode the rate of urinary amylase excretion was moderately elevated for up to six days but did not reach diagnostic levels. Persistent elevation of serum amylase and lipase levels and hourly rates of urinary amylase excretion for more than six days suggested that a pseudocyst had developed. In acute pancreatitis the level of serum lipase was more frequently raised and persisted so for longer than either the serum or urinary amylase. Although the hourly rate of urinary amylase excretion is of little value alone, when performed in conjunction with evaluating the serum amylase and lipase it may provide useful additional evidence of pancreatic disease and it could be useful in the diagnosis of relapsing chronic pancreatitis.