tbuckley/cabot-search huggingface dataset:
AUTHOR'S REPLY
Authors: M. J Peters
Journal: Thorax (1992)

Letters to the Editor sequestration (not true "margination") in the pulmonary microvasculature.We would, however, suggest that such a rapid retention and subsequent release is much more likely to be due to changes in cell deformability, which is now generally believed to be the initiating factor in leucocyte sequestration before an increase in adherence.The importance of cell deformability as a determinant of neutrophil sequestration within human lungs has been demonstrated.'We2 and others' have shown that the effect of this tripeptide in vitro is to increase neutrophil rigidity within seconds by assembly of F-actin.Such a change is much more rapid than any up regulation of either leucocyte or endothelial adhesion ligands, which require minutes to hours.It is attractive to speculate that the inhala- tion of FMLP, either by a direct effect across the alveolar capillary cellular barrier or by indirect action via mediators released from macrophages or mesenchymal cells, impairs the deformability and hence transit ofneutro- phils through the pulmonary vascular bed.
Novel Myeloma-Associated Antigens Revealed in the Context of Successful Syngeneic Hematopoietic Stem Cell Transplantation
Authors: Melinda A. Biernacki, Guanglan Zhang, Wandi Zhang, Vladimir Brusic, Robert J. Soiffer, Donna Neuberg, Edwin P. Alyea, Yu-Tzu Tai, Nikhil C. Munshi, Jerome Ritz, Kenneth C. Anderson, Catherine J. Wu
Journal: Blood (2008)
Commentaire de travail de V. Gómez et al., pp. 286
Journal: Endoscopy (2010)

See also: Interobserver agreement and accuracy among international experts with probe-based confocal laser endomicroscopy in predicting colorectal neoplasiaEndoscopy 2010; 42(04): 286-291DOI: 10.1055/s-0029-1243951
Addisonian crisis while taking high-dose glucocorticoids. An unusual presentation of primary adrenal failure in two patients with underlying inflammatory diseases
Authors: T. P. Jacobs
Journal: JAMA (1988)

The diagnosis of acute hypoadrenalism seldom is considered in patients without known adrenal insufficiency who are taking supraphysiologic amounts of glucocorticoids. We report two patients who presented in acute addisonian crisis on more than one occasion while taking high doses of glucocorticoids (30 to 40 mg of prednisone daily) for underlying inflammatory disease (recurrent pleuropericarditis and sarcoidosis). Evidence of severe mineralocorticoid deficiency was present in each patient, and the conditions of both improved remarkably when mineralocorticoid was added to their regimens. The cause of primary adrenal failure and its acute presentation was unclear in both patients but is presumed to be related to the underlying inflammatory disease. (<i>JAMA</i>1988;260:2082-2084)
BELGIUM
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characterization of Cytotoxic Effect of Asbestos on Normal Human Fibroblasts
Authors: Ming J. W. Chang, Narendra P. Singh, Angelo Turturro, Ronald W. Hart
Journal: Environmental Health Perspectives (1983)

Using viable cell counting and the incorporation of radioactive thymidine in cell TCA precipitate, we have attempted to separate the effects of asbestos on cell growth inhibition (reproductive failure) vs. cell killing. NIEHS crocidolite and NIEHS intermediate-sized chrysotile at a concentration of 10 micrograms/mL were studied. Cytotoxic effects were demonstrated with both types of asbestos. Thymidine incorporation expressed as cpm/viable cell was enhanced in the presence of either form of asbestos. It is concluded that both negatively charged crocidolite and positively charged chrysotile are toxic to human fibroblast cells in culture and exert their cell killing but not growth inhibition effect concurrently with a stimulation of DNA synthesis.
Keynote-365 cohort C: Pembrolizumab (pembro) plus enzalutamide (enza) in abiraterone (abi)-pretreated patients (pts) with metastatic castrate resistant prostate cancer (mCRPC).
Authors: Peter C.C. Fong, Margitta Retz, Alexandra Drakaki, Christophe Massard, William R. Berry, Emanuela Romano, Johann S. De Bono, Susan Feyerabend, Leonard Joseph Appleman, Henry Jacob Conter, Srikala S. Sridhar, Neal D. Shore, Mark David Linch, Anthony Joshua, Howard Gurney, Haiyan Wu, Charles Schloss, Christian Heinrich Poehlein, Evan Y. Yu
Journal: Journal of Clinical Oncology (2019)

171 Background: Pembro has antitumor activity as monotherapy in pretreated advanced mCRPC (KEYNOTE-028; KEYNOTE-199). A study has suggested that pembro + enza after progression on enza may have clinical activity. KEYNOTE-365 (NCT02861573) is a phase 1b/2 umbrella study testing combinations in mCRPC; we report early results from cohort C combining pembro + enza in mCRPC. Methods: Patients who failed or became intolerant to ≥4 weeks of abi in the pre-chemotherapy mCRPC state were included. Pts also had to have progressed within 6 months prior to screening as determined by either PSA progression or radiologic progression in bone or soft tissue. Pts received pembro 200 mg intravenously Q3W with enza 160 mg per day orally, and response was evaluated by PSA levels Q3W and imaging Q9W for the first year and Q12W thereafter. Primary end points were safety and PSA response rate (confirmed PSA decline ≥50%). Key secondary end points were investigator-assessed ORR (RECIST v1.1), disease control rate (DCR: CR+PR+SD ≥6 mo), time to PSA progression, rPFS, and OS. Results: 69 pts initiated treatment (median age 69 years; PD-L1+ 30%; visceral disease 26%; measurable disease 36%). Median (95% CI) follow-up was 9 (7-13) mo. See efficacy outcomes in table. Treatment-related AEs occurred in 63 (91%) pts; most frequent (≥20%) were fatigue (30%), rash (23%), and nausea (22%). Grade 3-4 treatment-related AEs occurred in 28 (41%) pts; no deaths were due to treatment-related AEs. Conclusions: Early results from the pembro + enza combination show sustained activity in abi-pretreated frontline mCRPC. Observed safety profile for the combination treatment was consistent with the known safety profiles of pembro and enza. Clinical trial information: NCT02861573. [Table: see text]
Unintentional Carbon Monoxide Poisoning Following Winter Storm—Washington, January 1993
Journal: JAMA (1993)

Carbon monoxide (CO) poisoning was a major health consequence of a severe storm that struck the Puget Sound region of western Washington state the morning of January 20, 1993. Wind gusts up to 94 miles per hour interrupted electrical power for an estimated 776,000 residents, and during the 4 nights following the storm, temperatures fell to near freezing. Because of the use of alternative sources of energy for indoor cooking and home heating, the risk of exposure to CO increased for many persons. This report summarizes cases of storm-related CO poisoning among persons who were initially evaluated at Seattle's Harborview Medical Center (HMC) or who were referred to the Virginia Mason Medical Center (VMMC) for hyperbaric oxygen therapy.
Abstract 1076: Conditional Fkbp12.6 Overexpression In Mouse Cardiac Myocytes Protects From Triggered Ventricular Arrhythmia Through Specific Alteration In Ec Coupling
Authors: Barnabas Gellen, Ana-Maria Gomez, Khai Le Quang, Francois Briec, Laurent Vinet, Patricia Rouet, Jean-Pierre Benitah, Mylene Pezet, María Fernández-Velasco, Gael Palais, Noemie Pellegrin, Andy Zhang, Romain Perrier, Brigitte Escoubet, Sylvain Richard, Frederic Jaisser, Flavien Charpentier, Jean-Jacques Mercadier
Journal: Circulation (2007)

In cardiac myocytes, Ca2+ release from the sarcoplasmic reticulum (SR) into the cytoplasm via the ryanodine receptor (RyR2) activates cell contraction. During diastole, RyR2 are closed and prevent Ca2+ efflux from the SR. One of the major regulators of RyR2 function is FKBP12.6. Binding of FKBP12.6 stabilizes RyR2 in the closed formation in diastole and contributes to synchronized RyR2 opening in systole. Beta-adrenergic stimulation dissociates FKBP12.6 from RyR2, leading to diastolic Ca2+ leak that can trigger ventricular tachycardias (VT). We tested the hypothesis whether FKBP12.6 overexpression in the myocardium can reduce the susceptibility to VT in stress conditions. We developed a mouse model with conditional cardiac specific overexpression of FKBP12.6 using the Tet-Off system. Transgenic (TG) mice and controls (CT) were examined by echocardiography, PV-catheterization, ECG, and underwent intracardiac stimulation to trigger VT before and after pre-treatment with isoproterenol. In isolated cardiac myocytes, SR Ca2+ load, Ca2+ sparks and Ca2+ transient were measured using confocal microscopy, and L-type Ca2+ current was determined by the patch-clamp technique. Echocardiography, PV-catheterization and ECG recording did not reveal differences between Tg (n=11) and CT (n=13) mice. Burst pacing (figure 1) could induce TV in 4 of 24 controls and in 0 of 14 TG mice (n.s.). Following pre-treatment with isoproterenol, TV could be induced in 10 of 23 controls, but only in 1 of 14 TG animals (figure 2, p&lt;0.05). In isolated myocytes, decreased Ca2+ spark frequency, increased Ca2+ spark size, unchanged SR Ca2+ load and decreased Ca2+ transient were observed in TG cells (n=19) as compared to controls (n=48, p&lt;0.05). L-type Ca2+ channel current was found to be decreased in Tg myocytes (n=29 vs n=32, p&lt;0.01). We conclude that myocardial FKBP12.6 overexpression has a protective effect against VT induced by rapid pacing after pretreatment with catecholamines. This antiarrhythmic effect is probably, at least in part, linked to decreased diastolic SR Ca2+ leak. Our results support the hypothesis that increased FKBP12.6 binding to RyR2 might represent a potential therapeutical target in the prevention and treatment of ventricular arrhythmias.
Thanks to gift from Ross Perot, University of Texas Southwestern's MD-PhD Program triples in size
Authors: A. A. Skolnick
Journal: JAMA (1993)

FIVE YEARS AGO, Dallas billionaire and 1992 independent presidential candidate H. Ross Perot gave the University of Texas Southwestern Medical Center at Dallas a $20 million 10-year grant to support medical research and to help train future scientists. This fall, halfway through the grant period, enrollment in the school's Medical Scientist Training Program will increase to 82 students, which is more than three times the number of students who were in the combined degree program when Perot's gift was announced. According to Rodney Ulane, PhD, associate dean of Southwestern's Medical Scientist Training Program, approximately one third of the grant is going to support MD-PhD candidates, allowing them to complete the 7-year to 8-year program without incurring significant personal debt. Students in the program receive full-tuition scholarships plus escalating annual stipends that begin at $12 000 for the first 2 years and reach $18000 by the sixth year of study. Only
Genotypic analysis of cutaneous T-cell lymphoma: a comparative study of Southern blot analysis with polymerase chain reaction amplification of the T-cell receptor-γ gene
Authors: N. CURCÓ, O. SERVITJE, M. LLUCIA, J. BERTRAN, A. LIMÓN, M. CARMONA, V. ROMAGOSA, J. PEYRÍ
Journal: British Journal of Dermatology (1997)
Medical Communications of the Massachusetts Medical Society.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neisseria gonorrhoeae Conjunctivitis
Authors: Eduardo Alfonso
Journal: JAMA (1983)

Ten patients with gonococcal conjunctivitis were examined during an epidemic of acute hemorrhagic conjunctivitis (AHC). Eye cultures in all cases demonstrated<i>Neisseria gonorrhoeae</i>, and seven also had isolates of<i>N gonorrhoeae</i>in genital specimens. All patients responded well to antimicrobial therapy. The patients had used a folk remedy in which they had applied urine to their eyes to treat the symptoms of AHC. (<i>JAMA</i>1983;250:794-795)
A phase II trial of RAD001 in patients (Pts) with metastatic renal cell carcinoma (MRCC)
Authors: J. Jac, S. Giessinger, M. Khan, J. Willis, S. Chiang, R. Amato
Journal: Journal of Clinical Oncology (2007)

5107 Background: RAD001 is an oral mammalian target of Rapamycin (mTOR) inhibitor. Three mechanisms of anti-tumor activity; shuts down tumor response to nutrients and growth factors; cell cycle arrest at late G1 and anti-angiogenesis via VEGF. Molecular alterations in the mTOR modular pathway increase sensitivity in PTEN deficient tumors such as RCC. Endpoints: time-to-progression (TTP), response rate (RR), overall survival (OS), toxicity, and to assess changes in metabolic imaging utilizing CT-PET. Methods: Eligibility included; predominant clear cell, progressive measurable MRCC, adequate organ/marrow function, zubrod performance status (ZPS) = 2, no more than 1 prior therapy, and no active CNS involvement. RAD001 is given orally at a dose of 10mg daily without an interruption (28-day cycle), with dose modifications for toxicity. Re-evaluation was assessed every 2 cycles (8 weeks). RECIST criteria is utilized. TTP and OS are determined from entry into the study. Results: 41 pts have been enrolled. 37 pts are evaluable for response/toxicity. 2 pts toxicity only. 2 pts screened failures. 31 were male/8 female, median age 60 (38–80) years. 31 pts received prior therapy. 23 pts had a ZPS of 0, 13 /1 and 3/2. Sites of disease included; lung, nodal, liver, bone, adrenal, and kidney. 9 pts had 1 metastatic site, 17 pts/2 and 13 pts/3 or more. 15 pts continue to receive RAD001. 12 pts had partial responses, 19 pts were stable for 3+ months. Median duration of therapy is 8+ (range 01–20+) months. Treatment related adverse events; mucositis, skin rash, pneumonitis, hypophosphatemia, hyperglycemia, hypertriglyceridemia, hypercholesterolemia, thrombocytopenia, anemia and elevated LFTs. PET scans have demonstrated decreased metabolic activity in responding or stable pts. Median overall survival is 11.5+ months (range 01–20+). Conclusion: RAD001 has promising anti-tumor activity in pts with MRCC demonstrated by partial response rate. Anti-tumor activity is further suggested by prolonged TTP =3 months. Anti-tumor activity, toxicity and metabolic imaging correlation will be presented. An additional 40 pts who failed prior sunitinib or sorafenib therapy are being enrolled. No significant financial relationships to disclose.
MEDICAL PUBLICITY
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermatofibrosarcoma protuberans
Authors: C.D.M. Fletcher, P.H. McKee
Journal: British Journal of Dermatology (1984)

Journal Article Dermatofibrosarcoma protuberans Get access C.D.M. Fletcher, C.D.M. Fletcher Department of Histopathology, St Thomas's Hospital Medical School, London, SE1 7EH Search for other works by this author on: Oxford Academic Google Scholar P.H. McKee P.H. McKee Department of Histopathology, St Thomas's Hospital Medical School, London, SE1 7EH Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Page 35, https://doi.org/10.1111/j.1365-2133.1984.tb05259.x Published: 01 July 1984
Serum uric acid and cholesterol variability. A comprehensive view of underwater demolition team training
Authors: R. H. Rahe
Journal: JAMA (1968)

One-third (32 men) of a Navy Underwater Demolition Team training class was investigated by psychological assessment and serum uric acid and cholesterol determinations three times a week until they either withdrew from training or graduated. In general, significant elevations in serum uric acid levels occurred when trainees were eageriy taking on arduous activities with an optimistic attitude and determination to succeed. Significant elevations in serum cholesterol levels were seen in training situations in which the men felt overburdened by environmental variables, when they were relatively physically inactive, and, for selected individuals, when they failed portions of the training course.
Correction: Missing Figure
Journal: Annals of Internal Medicine (2000)

Corrections18 January 2000Correction: Missing FigureFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-2-200001180-00024 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Because of a printing error, the figure in a recent article on β-blockade after acute myocardial infarction in elderly persons (1) was omitted. The figure is reprinted on this page.Figure. Use of β-blocker therapy in the United States, by state or territory. Download figure Download PowerPoint Reference1. Krumholz HM, Radford MJ, Wang Y, Chen J, Marciniak TA. Early β-blocker therapy for acute myocardial infarction in elderly patients. Ann Intern Med. 1999;131:68-54. LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEarly β-Blocker Therapy for Acute Myocardial Infarction in Elderly Patients Harlan M. Krumholz , Martha J. Radford , Yun Wang , Jersey Chen , and Thomas A. Marciniak Metrics 18 January 2000Volume 132, Issue 2Page: 167KeywordsAcute myocardial infarctionElderly ePublished: 15 August 2000 Issue Published: 18 January 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
NEWS AND VIEWS
Authors: Warren Lang, Roscoe Brady, T Odell, Elliot Osserman, New York, N Kermit, N Lawrence, J Oncley, Rose Payne, Myron Pollycove, Armand Quick, D Ratnoff, John Cleveland, Mich Rebuck, N Rochester, C Martin, New Rosenthal, D Jean
Journal: Blood (1964)
Table of Contents
Authors: James Macdonald, Brooke Macdonald, Loren Golitz, Patricia Lorusso, Aleksandar Sekulic, ; Provo, Theresa Canavan, Erin Mathes, Ilona Frieden, Kanade Shinkai, ; Birmingham, San Francisco, Elisa Funck-Brentano, Tu-Anh Duong, Sophie Bouvresse, Martine Bagot, Pierre Wolkenstein, Jean-Claude Roujeau, Olivier Chosidow, Laurence Valeyrie-Allanore, Tara Rachakonda, Jaskaran Dhillon, Aleksandra Florek, April Armstrong, Megan Desai, Shuling Liu, Sareeta Parker, ; Atlanta, Richard Hoppe, Cameron Harrison, Mahkam Tavallaee, Sameer Bashey, Uma Sundram, Shufeng Li, Lynn Million, Bouthaina Dabaja, Pamela Gangar, Madeleine Duvic, Youn Kim, Johanna Sheu, Elena Hawryluk, Dongjing Guo, Wendy London, Jennifer Huang, ; Boston, J Am, Acad Dermatol, Hyoseung Shin, Ho Ryu, Junghee Yoon, Seongmoon Jo, Sihyeok Jang, Mira Choi, Ohsang Kwon, ; Goyang, Emilie Brenaut, Pascale Marcorelles, Steeve Genestet, Dominique Me´nard, Laurent Misery, Marine Berton, Ge´rard Lorette, Emmanuelle Lagrue, Sophie Blesson, Fre´de´ric Cambazard, Lo€ Ic Vaillant, Annabel Maruani, Thomas Knackstedt, Faramarz Samie, New Hampshire, Alice Gottlieb, Adriane Levin, April Abernethy, Kristina Duffin, Reva Bhushan, Amit Garg, Joseph Merola, Mara Maccarone, Robin Christensen, Andrew Kelsey, Jane Grant-Kels, Michael Payette, ; Farmington, Liisa Va¨keva¨, Soili Ma¨kinen-Kiljunen, Annamari Ranki, Giuseppe Micali, Francesco Lacarrubba, Maria Nasca, Elisa Song, Luis Dehesa, Catherine Kowalewski, San Antonio, Jenny Murase, Robert Rudolph
Journal: Journal of the American Academy of Dermatology (2015)
The epidemiology of acquired immunodeficiency syndrome among heterosexuals
Authors: H. W. Haverkos
Journal: JAMA (1988)

THE PURPOSE of this article is to inform health care professionals about the extent to which human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) are spreading to the heterosexual population in this country. In this introduction, we present generalities about the sexual revolution (which represent our interpretation of readings of the popular press) and review the chronology of risk groups for AIDS identified by the Centers for Disease Control (CDC). In later sections, we discuss and critique data concerning heterosexual spread of HIV infection and AIDS reported in the United States and in other parts of the world. Finally, we reiterate the Public Health Service's recommendations designed to reduce sexual transmission of HIV infection. Over the last several decades, many societies have undergone a sexual revolution of vast magnitude. Several recent technological advances have preceded this revolution. The discovery of penicillin and other antibiotics that control some sexually