tbuckley/cabot-search huggingface dataset:
Manuscripts Approved for JNCI, December 1973-January 1974
Journal: JNCI Journal of the National Cancer Institute (1974)

Manuscripts Approved for JNCI, December 1973-January 1974 Get access JNCI: Journal of the National Cancer Institute, Volume 52, Issue 2, February 1974, Page 628, https://doi.org/10.1093/jnci/52.2.628-a Published: 01 February 1974
Correction
Journal: BMJ (1955)

ANY QUESTIONS?MBJRx must be remembered that there is no musculature in the wall of the diverticulum, so that if it becomes filled with inspis- sated faecal material it cannot empty itself: the colonic contents should therefore be kept, so far as possible, soft and moist.In the absence of inflammation pain is due to the associ- ated colonic spasm, so in an attack the administration of bowel antispasmodics is often valuable.Ordinary purges should be avoided, since they tend to increase spasm, but an occasional Studa chair colonic wash-out, say once a month, may be well worth a trial.On a simple regime such as this many cases of diverticulosis carry on for a great number of years without any serious complication arising.
SERPINB3 inhibition as a novel target therapy for non-alcoholic steatohepatitis
Authors: Andrea Martini, Gianmarco Villano, Santina Quarta, Cristian Turato, Mariagrazia Ruvoletto, Alessandra Biasiolo, Andrea Cappon, Erica Novo, Stefania Cannito, Maria Guido, Maurizio Parola, Patrizia Pontisso
Journal: Journal of Hepatology (2020)
The Tzanck smear in the diagnosis of cutaneous herpes simplex
Authors: A. R. Solomon
Journal: JAMA (1984)

We examined the effectiveness of the Tzanck preparation compared with viral isolation in 32 lesions of cutaneous herpes simplex infection in 30 consecutive patients. Seventy-eight percent had positive cultures, even though the clinical history and lesion morphological findings were typical in all situations. Other authors have also noted that viral isolation does not reach 100% even in the face of typical clinical history. Fifty-three percent of the Tzanck smears were positive. These preparations had a high correlation with positive viral cultures (94.1%). Vesicles were more likely to yield a positive culture than Tzanck smear (100% and 66.7%, respectively). Pustules yielded positive cultures in 72.8% and positive Tzanck smears in 54.5%, while crusted-ulcer lesions were usually not positive by either technique (34%, 16%). A positive Tzanck preparation is an accurate, rapid tool for the diagnosis of cutaneous herpes simplex. (<i>JAMA</i>1984;251:633-635)
Corrigendum
Journal: BMJ (1934)

THEIBCLJOURTSnis probably his best course, but possibly it might be ad- visable to have the assistance of an accountant with that claim.Interest Paid out of Profits R. C." puts the following query.A lends B £1,000 for the purchase of a practice on which B pays £50 per annum interest, and that sum is included in the assessed profits of the practice.Does A also pay tax on the £50? *** B pays tax on the £50 (at full standard rate) as part of the profits of the practice.WVhen he makes pay- ments to A he is entitled to deduct tax, so that a quarterly payment would be £12 10s.less £2 16s.3d.
The Hypochondriac
Authors: Aula Abbara
Journal: BMJ (2005)

By Molière Directed by Lindsay Posner Almeida Theatre, London, until 7 January 2005 www.almeida.co.uk Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Lindsay Posner's production of this Molière translation provides an evening of farce and silliness with semitragic undertones. The antihero Argan (played by Henry Goodman) is the self pitying hypochondriac of the title whose obsession with his bowels and bodily emissions allows to him fall prey to the cream of French medical quacks. Goodman plays him with insecure energy as he sits in his overlarge armchair/commode, his feet not quite reaching the ground and red clogs perched on his toes, … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Cardiopulmonary resuscitation
Authors: H. J. Heimlich
Journal: JAMA (1993)

<h3>In Reply.</h3> —Our study does not contradict the AHA guidelines recommending the Heimlich maneuver for use only for suspected foreign body obstruction in the submersion victim.<sup>1</sup>While bystander CPR was not associated with improved outcome in drowning, the majority of study victims (78%) had received bystander CPR, making comparison difficult between the bystander and no-bystander groups. Moreover, these two groups included victims with both short and long submersion durations. Most submersion victims' fates are determined by the duration of their submersion; we recommended that future studies evaluating an intervention should assess and control for submersion duration. The statement that there are no controlled studies supporting CPR in submersion victims is incorrect. A recent study compared the outcome of submersion victims treated with varying degrees of CPR and controlled for submersion duration.<sup>2</sup>All victims receiving some degree of CPR did better than those who had none; the ones who
The role of H-Y antigen in primary sex determination
Authors: S. Ohno
Journal: JAMA (1978)

The basic embryonic plan of mammals is inherently feminine. Male development is due to two-step interventions of this basic plan: the Y chromosome directs the embryonic indifferent gonad to organize a testis instead of an ovary; the Y-organized testis synthesizes and secretes testosterone, which induces all the extragonadal masculine development. The Y chromosome plays no direct and appreciable role in extragonadal masculine development. Testicular organization, normally under the direction of the Y, is the function of the evolutionary conserved plasma membrane protein serologically detectable as H-Y antigen. Under specific circumstances, H-Y antigen may be expressed in the absence of the Y chromosome, thus producing XO and XX males. If H-Y antigen is not expressed, XY individuals develop as females. H-Y antigen is the first plasma membrane or cell surface protein to which a specific organogenesis function has been assigned. (<i>JAMA</i>239:217-220, 1978)
Bacteria of the gut.
Journal: BMJ (1969)

PointersObstetric Analgesia: Comparison of methoxyflurane with nitrous oxide given in continuously adjusted concentration by an anaesthetist showed them to be almost equally effective obstetric analgesics (p. 255); Comparison of intermittent self-administration of the two gases showed methoxyflurane to be a more effective analgesic, and it produced less nausea and vomiting than nitrous oxide (p.259) ; Field trial in 1,257 patients supports use of methoxyflurane in mid- wifery practice and confirms that the objective method used for screening an inhalational agent is satisfactory (p.263).Serum Hepatitis: In outbreak among staff of haemodialysis unit a disproportionate number of patients were of blood group 0, and most severe cases also had this blood group (p. 268).. Filter-tipped Cigarettes: Bronchial reactivity to cigarette and cigar-tobacco smoke was reduced in heavy smokers by increasing the retention efficiency of the filters (p.269).Sickle-cell Anaemia: No evidence of metabolic acidosis during " painful crises " found in 10 adults.This could explain failure of alkalis in treatment (p. 271).Typhoid Perforation: Treatment by laparotomy with closure and drainage in 121 cases gave mortality of 30%, but mortality rose to 76% when surgery was performed more than 5 days after perforation (p. 273).Response to Fructose: Catabolite of fructose may be responsible for rise in plasma insulin and corticoid levels found in 12 normal subjects and in seven diabetics (p. 277). RheumatoidArthritis: Anti-inflammatory effects of salicylate and indomethacin studied by radioisotopic method.Only indomethacin cleared isotope from the joint (p. 278).Respiratory Distress : Rare cause (p. 281).
MEETINGS OUTSIDE THE UNITED STATES
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deaths involving propoxyphene. A study of 41 cases over a two-year period
Authors: W. Q. Sturner
Journal: JAMA (1973)

Forty-one deaths occurred involving propoxyphene hydrochloride (Darvon) during a two-year period. Ten patients died from propoxyphene intoxication alone, while 12 were victims of a propoxyphene-alcohol combination, the latter number being identical to the deaths from a combination of barbiturates with alcohol seen during the same period. Five young women died from an ingestion of propoxyphene following an "argument." Four patients could be categorized as "drug abusers" due to historical circumstances. The high levels of propoxyphene suggested habituation in three instances. Physicians should be alerted to the potential deleterious effects of indiscriminate use and abuse of propoxyphene, and should warn their patients not to drink alcoholic beverages when taking propoxyphene. They should use extreme caution when prescribing it to those in the younger age group.
Kinetics of circulating plasma vascular endothelial growth factor in children with kawasaki disease Jun Furui, Masahiro Ishii, Hisao Ikeda, Teiji Akagi, Hirohisa Kato, Hirohisa Kato, Hirohisa Kato. Kurume Univ., Kurume, Japan
Journal: Journal of the American College of Cardiology (2001)
The Debt
Authors: Ted Louie
Journal: Annals of Internal Medicine (2009)

On Being a Doctor6 January 2009The DebtTed Louie, MD*Ted Louie, MD*From the University of Medicine & Dentistry of New Jersey, New Brunswick, NJ 08901.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-1-200901060-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail According to Chinese legend, there once was an old man who lived in the shadow of 2 mountains. He was unable to move about freely, so he resolved to move the mountains. He gathered his sons together, and they immediately set about digging. His neighbors came by and scoffed at the old man's folly. The old man replied calmly, “I have sons, and my sons will have sons, and their sons will have sons. Yet, the mountain will never grow higher.” The old man's determination was felt even in the heavens, and 2 immortals rewarded him by removing the mountains.... Author, Article, and Disclosure InformationAffiliations: From the University of Medicine & Dentistry of New Jersey, New Brunswick, NJ 08901.Corresponding Author: Ted Louie, MD, 579A Cranbury Road, East Brunswick, NJ 08816; e-mail, [email protected]com.* As told to him by his mother, Gloria Wong Louie. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 January 2009Volume 150, Issue 1Page: 55-56KeywordsAdolescentsChildrenChinese peopleEmotionsForecastingHeartInfantsPediatricsSalmonellaVision ePublished: 6 January 2009 Issue Published: 6 January 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Malignant Conversion Step of Mouse Skin Carcinogenesis
Authors: Stuart H. Yuspa, Henry Hennings, Dennis Roop, James Strickland, David A. Greenhalgh
Journal: Environmental Health Perspectives (1990)

Multiple benign squamous papillomas commonly precede the development of an occasional squamous cell carcinoma in mouse skin carcinogenesis. The incidence of carcinomas can be enhanced by treating papilloma-bearing mice with mutagens such as urethane, nitroquinoline-N-oxide, or cisplatinum. This observation suggests that a genetic change is required for malignant conversion. The malignant phenotype is characterized by a marked reduction in the transcription of specific epidermal differentiation markers, a pattern which is useful for the early diagnosis of malignant conversion. Cells expressing a benign phenotype can be obtained by introducing the v-rasHa oncogene into cultured epidermal cells by a replication-defective retrovirus. Alternatively, benign tumor cells can be cultured from papillomas induced by chemical carcinogens in vivo or from carcinogen-treated mouse epidermis. In all cases, the benign phenotype in vitro is characterized by an altered biological response to changes in extracellular calcium, an important determinant of the differentiation state of cultured normal keratinocytes. Transfection of cloned plasmid DNA into benign tumor cells has revealed that transforming constructs of the fos oncogene induce malignant conversion, whereas myc and adenovirus E1A oncogenes do not. The fos carcinomas do not express differentiation-specific epidermal markers and secrete proteases such as transin and urokinase, a set of characteristics previously noted for chemically induced skin carcinomas. Cultured normal epidermal cells, exposed to the v-ras and the v-fos oncogenes simultaneously, are malignantly transformed. Alone, the fos oncogene does not detectably alter the phenotype of normal keratinocytes. These studies indicate that a limited number of genes is involved in epidermal carcinogenesis.
Prostate Early Detection Clinical Practice Guidelines in Oncology
Journal: Journal of the National Comprehensive Cancer Network (2004)

Prostate cancer is the most commonly diagnosed cancer in American men and the second leading cause of cancer deaths. In 2004, nearly 20 million men in the United States will be confronted with important decisions regarding early detection for prostate cancer. In brief, the dilemma is that because not all men with prostate cancer die of the disease, treatment is not necessary for some patients. However, an estimated 29,900 patients will die of prostate cancer in 2004. Therefore, differentiating between patients whose cancer is clinically insignificant and those whose disease will progress is a challenge. The NCCN Prostate Cancer Early Detection Clinical Practice Guidelines in Oncology provide a set of sequential recommendations detailing a screening and subsequent work-up strategy for maximizing the detection of prostate cancer in an organ-confined state while attempting to minimize unnecessary procedures.For the most recent version of the guidelines, please visit NCCN.org
Neurologic Diagnosis.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma high-density lipoprotein cholesterol level. Influence of risk factor intervention
Authors: S. B. Hulley
Journal: JAMA (1977)

Determinants of circulating high density lipoproteins (HDL) were sought in 301 men studied during a year of participation in a coronary prevention program. Mean plasma HDL-cholesterol concentration rose by 2.8 mg/dl (6%) in the group receiving multifactor intervention, but the change did not differ significantly from that in the comparison group. Larger changes in both directions were seen in many individuals. Multiple regression analysis of these changes indicates that increased plasma HDL levels occur when plasma triglyceride level is decreased, cigarette smoking is reduced, and habitual alcohol intake is increased. Increases in the concentration of HDL-cholesterol also tended to accompany adherence to the fat-controlled diet, reduction in LDL-cholesterol level, and loss of body weight. Conventional coronary prevention programs are unlikely to have an adverse influence on this new, risk-lowering factor. (<i>JAMA</i>238:2269-2271, 1977)
Medulloblastoma: Clinical and biologic aspects
Authors: Roger J. Packer, Philip Cogen, Gilbert Vezina, Lucy B. Rorke
Journal: Neuro-Oncology (1999)

Neuro-OncologyMedulloblastoma is the most common childhood primary CNS tumor, and treatment approaches have evolved over the past three decades.The biologic underpinnings of medulloblastoma are not fully characterized, but recent work has identi ed new, important directions for research.Strati cation of patients with medulloblastoma into risk groups is the backbone of most ongoing therapeutic studies.Patients are usually characterized as being either average risk or poor risk, although an intermediate risk group may exist.Standard treatment for older children with medulloblastoma consists of radiation and, for most, chemotherapy.Children with nondisseminated disease at the time of diagnosis have been reported to have as high as an 80% ve-year disease-free survival rate after treatment with reduced dose (2340 cGy) craniospinal irradiation, local boost radiation therapy (5500 cGy), and chemotherapy, given during and after radiation therapy.Preradiation chemotherapy has yet to be shown to be of bene t for children with medulloblastoma.Children with disseminated disease are a highly problematic subgroup of patients to treat.A variety of new approaches are being studied, most of which are intensifying chemotherapy either prior to or after radiation.Long-term survivors of medulloblastoma are at signi cant risk for permanent endocrinologic, cognitive, and psychological sequelae.Infants and very young children with medulloblastoma remain a dif cult therapeutic challenge because they have the most virulent form of the disease and are at highest risk for treatment-related sequelae.
International Symposium on Hexachlorobenzene (HCB)
Journal: JNCI Journal of the National Cancer Institute (1984)

International Symposium on Hexachlorobenzene (HCB) Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 6, December 1984, Pages 1491–1492, https://doi.org/10.1093/jnci/73.6.1491-f Published: 01 December 1984
Physical Diagnosis. Diseases of the Thoracic and Abdominal Organs. A Manual for Students and Physicians.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Confidence Intervals
Authors: WARREN S. BROWNER
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 December 1986Confidence IntervalsWARREN S. BROWNER, M.D., M.P.H., THOMAS B. NEWMAN, M.D., M.P.H.WARREN S. BROWNER, M.D., M.P.H., THOMAS B. NEWMAN, M.D., M.P.H.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-6-973_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Both Simon (1) and Rothman (2) advocate the use of confidence intervals when reporting the results of scientific research. Although we agree with their basic recommendations, we want to sound a note of caution.Contrary to common belief, determining the 95% confidence interval for a value does not imply that there is a 95% probability that the true value is contained within that interval. As an example, consider the following hypothetic experiment. Suppose an investigator performs a randomized, double-blinded trial comparing dextrose and sucrose in the treatment of 200 patients with malignant melanoma. The results show a...References1. SIMON R. Confidence intervals for reporting results of clinical trials. Ann Intern Med. 1986;105:429-35. LinkGoogle Scholar2. ROTHMAN K. Significance questing [Editorial]. Ann Intern Med. 1986;105:445-7. LinkGoogle Scholar3. FLEISS J. Statistical Methods for Rates and Proportion. 2nd ed. New York: John Wiley & Sons; 1981:29. Google Scholar4. Webster's New Collegiate Dictionary. Springfield, Massachusetts: G.&C. Merriam Company; 1979:234. Google Scholar5. ROTHMAN K. A show of confidence. N Engl J Med. 1978;299:1362-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WARREN S. BROWNER, M.D., M.P.H.; THOMAS B. NEWMAN, M.D., M.P.H.Affiliations: University of California San Francisco; San Francisco, CA 94121 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA guide to clinical epidemiology for radiologists: Part I study design and research methodsMore on Torturing DataA model research curriculum for emergency medicineOn the construction of shortest confidence intervals and Bayesian highest posterior density intervals 1 December 1986Volume 105, Issue 6Page: 973-974KeywordsConfidence intervalsGlucoseMelanomaPatientsSucrose ePublished: 1 December 2008 Issue Published: 1 December 1986 PDF downloadLoading ...