tbuckley/cabot-search huggingface dataset:
Abstract 782: Exploring the contribution of introgressed ancient DNA to prostate cancer racial disparity
Authors: Evi O. Useh, Suresh Venugopal, Chidi N. Molokwu
Journal: Cancer Research (2021)

Abstract Introduction: Prostate cancer is the most common cancer in men and there is racial disparity in prostate cancer incidence and mortality globally, with greater disease burden in men of African ancestry, followed by European ancestry and least in men of Asian ancestry. The etiology of prostate cancer is not fully understood, but includes genetic and environmental factors. Present day non-Africans are reported to have introgressed DNA from Neanderthal and Denisovan ancestors. Over 170 prostate cancer associated single nucleotide polymorphisms (SNPs) have been identified from several genome-wide association studies (GWAS), with SNPS on chromosomes 2, 8 and 22 reported as showing variation between African and non-African men with prostate cancer. We performed analysis of prostate cancer associated SNPs on chromosomes 2, 8 and 22 to determine if DNA introgression could explain the racial variation. Methods: We obtained data on prostate cancer associated SNPs from the GWAS catalog (https://www.ebi.ac.uk/gwas) and from reports that were not included in the catalog. Using an Ancient Genome Browser provided by the Max Plank Institute (https://www.eva.mpg.de/genetics/genomeprojects/neandertal/index.html), we determined whether SNPs on chromosomes 2, 8 and 22 were present in African, Neanderthal or Denisovan genomes. Based on the results, we inferred that SNPs were introgressed if they were present in Neanderthal or Denisovan genomes but absent from African genomes. Results: 49, 59 and 17 prostate cancer SNPs were reported in chromosomes 2, 8 and 22 respectively. 23/49 in ch2, 25/59 in ch8 and 9/17 in ch22 were present in Neanderthal and or Denisovan genomes. SNPs in ch2 (rs13403657, rs12621278) and ch8 (rs7825414) were present in Neanderthal or Denisovan genomes but absent in African genomes. These SNPs lie in regions that have previously been reported to harbor introgressed DNA. Conclusion: Our analyses identified prostate cancer associated SNPs that are likely to have been introgressed into present day non-Africans by extinct Neanderthal and Denisovan ancestors. Phenotypic changes caused by introgressed DNA could be contributing to racial disparities in prostate cancer in present day humans. Citation Format: Evi O. Useh, Suresh Venugopal, Chidi N. Molokwu. Exploring the contribution of introgressed ancient DNA to prostate cancer racial disparity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 782.
Current Cancer Research: Springboards for the Future
Journal: JNCI Journal of the National Cancer Institute (1984)

Current Cancer Research: Springboards for the Future Get access JNCI: Journal of the National Cancer Institute, Volume 73, Issue 5, November 1984, Pages 1243–1244, https://doi.org/10.1093/jnci/73.5.1243-e Published: 01 November 1984
NORWEGIAN HOSPITALS
Authors: Albert S. Welch
Journal: JAMA (1924)

<h3>To the Editor:</h3> —New hospital decorations at Ullevaal, the Christiania community sickhouse, are much brighter than the old ones. I went through the wards for infectious diseases the other day with Dr. Ustvedt, who explained that the present colors were used partly as an experiment and to get away from the more drab colors previously used. The walls had been yellow and tan before. Now the rooms are in light blue and gray. The curtains are blue. The doors are white. The beds, chairs and medicine tables are white-enameled. A warm, cheery aspect is afforded by broad-striped, bright-red and white bed-covers, table cloths, and the garments worn by ambulant patients. In spite of the gray weather outside and the deep snow seen through the big windows, the rooms were strikingly pleasant, and so were most of the patients. Several English physicians, visiting a few days in Christiania from London, remarked
Caring for the Uninsured and Underinsured
Authors: Robert Zufall
Journal: JAMA (1991)

<h3>To the Editor. —</h3> My wife and I operate a free clinic that might serve as one model for provision of medical care to the uninsured. The clinic provides basic primary care and pediatric immunizations to people who cannot afford $50 for a blood pressure check or $100 for shots. It is open one night a week in the office of a local Hispanic community organization, and 15 to 20 patients are seen each night. They are screened for ability to pay, but almost everyone is accepted; a donation of $1 to $5 is encouraged. There are two to four volunteer physicians, one or two volunteer nurses, one or two volunteer secretaries, and one or two paid translators. Modest overhead costs are paid. The budget is under $10 000 a year, or about $10 per patient visit. Start-up costs for basic office equipment were about $3000, given by Warner Lambert.
Corrigendum to “Connective Tissue Growth Factor and its Role in Lung Adenocarcinoma Invasion and Metastasis”
Journal: JNCI Journal of the National Cancer Institute (2018)

An interested reader commented on PubPeer about the image in the lower panel of Fig 3A in this article that has been cited more than 127 times.We wanted to address this matter, but because the experiments were performed about 15-16 years ago, we could not find the original data for Fig. 3A when this issue was raised.Therefore, we ordered the materials and re-performed the experiment in Fig. 3A in 2017, and the results were completely the same, even after more than 13 years.As an additional control for the CRMP-1 immunoblot (MW¼62 Kd), we used the internal control beta-actin (MW¼42 Kd), not alpha-tubulin (MW¼55 Kd), which is also proved to be unaltered by CTGF treatment in this experiment.The result in Fig. 3A was still unchanged.Although the result is the same and does not change the conclusion of this article, we have sincerely asked the Journal to correct the article in order to show our responsibility, and this figure has been replaced in a corrected version online.We deeply regret the inconvenience and apologize to the scientific community for the correction of the article.
Late Esophageal Perforation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2606: Genetic contribution of MYC to the development of primary prostate cancer
Authors: Nichelle C. Whitlock, Shana Trostel, Rayann Atway, Elizabeth Walton, Brian J. Capaldo, Huihui Ye, Adam G. Sowalsky
Journal: Cancer Research (2019)

Abstract Despite the predictive value of Gleason score (Gs), the molecular characteristics and associated biology that underpin specific Gleason patterns (Gp) remain understudied. Based on previous data showing increased MYC activity in higher-grade Gp4 versus lower-grade Gp3 tumor foci and addressing the paradox that prostate cancer is not hyper-proliferative, we sought to examine the genetic contribution of MYC to locally-advanced prostate cancer development. We screened a series of Gs7 cancers in which the Gp3 and Gp4 components were adjacent and represented contributing elements of the index lesion. Tumor foci were collected by laser capture microdissection based on MYC staining and purified for RNA; transcriptome profiling was performed. To further guide our bioinformatics analyses, we generated a LNCaP prostate cancer cell line harboring MYC knockdown. RNA-seq and ChIP-seq was performed to identify differentially bound regions of the cistrome that correlate with altered gene expression and elucidate potential mechanism(s) of action for MYC in primary prostate cancer. In contrast to other reports, MYC knockdown had the effect of increasing global transcription. Moreover, the publicly available Cancer Genome Atlas (TCGA) prostate cancer dataset was curated according to MYC status based on extreme case design using reverse phase protein assay data. Preliminary results show: (1) increased MYC protein levels, but not proliferation, in Gp4 tumor foci as compared to adjacent Gp3, (2) distinct histology and biology based on MYC tumor status, and (3) found recurrent enrichment for gene sets cross-referencing differentially expressed genes between TCGA, tissue, and our engineered cell line. Of note, we observed recurrent enrichment for the Acosta Proliferation Independent MYC Targets Up gene set, which correlated with MYC activity. When this gene set was cross-referenced between all three datasets, the gene NOLC1 was identified. Nucleolar and coiled-body phosphoprotein 1 (NOLC1) plays an important role in rRNA synthesis and ribosome biosynthesis; its role in tumorigenesis appears context dependent. NOLC1 was found to be positively correlated with MYC expression and may thus contribute to MYC-driven prostate cancer. Although further cases are needed to determine the frequency at which NOLC1 drives MYC-driven prostate cancer, our results suggest a novel role for MYC in mediating development of locally-advanced prostate cancer. Citation Format: Nichelle C. Whitlock, Shana Trostel, Rayann Atway, Elizabeth Walton, Brian J. Capaldo, Huihui Ye, Adam G. Sowalsky. Genetic contribution of MYC to the development of primary prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2606.
ARTERIOSCLEROSIS, LIPIDS, AND CLOTTING MECHANISM
Journal: JAMA (1961)

Clotting and arteriosclerosis occasionally occur in the small pulmonary arteries as a direct result of repeated showers of emboli from leg veins in an otherwise normal individual. More often, however, the arteriosclerosis is associated with cardiovascular or pulmonary disease such as rheumatic disease with mitral stenosis or pulmonary emphysema. The common denominator, according to Thomas,<sup>1</sup>is thrombo-embolism. Harrison<sup>2</sup>produced plaques in the small pulmonary arteries of rabbits by repeated intravenous injection of fragments of blood clots. Thomas, in extending Harrison's studies, incorporated carbon particles into clots before injection, and later was able to demonstrate the carbon particles in them, thus providing evidence that the plaque arose from a clot. These plaques were devoid of fat, in contrast with plaques in human vessels such as the coronary arteries. The difference might be related to the fat content of food. Rabbits' chow contains about 2% of fat by weight, while
Analytic Approaches to Observational Studies With Treatment Selection Bias—Reply
Authors: Therese A. Stukel, Elliott S. Fisher, David E. Wennberg
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bouquet
Authors: John Patrick Murray
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aerosol beclomethasone treatment of chronic severe asthma. A one-year experience
Authors: S. A. Imbeau
Journal: JAMA (1978)

After one year's use of beclomethasone dipropionate aerosol, 43 of 61 asthmatic patients who were originally dependent on oral corticosteroids were able to reduce and 38 to completely eliminate use of oral corticosteroids. Most patients maintained or improved their pulmonary functions. Exacerbation of rhinitis during oral corticosteroid withdrawal and emergence of nasal polyps were problems for 25 patients. Exacerbation of asthma with upper respiratory infections was an important event: 21 patients required supplemental oral corticosteroids to control asthma. Oral candidiasis occurred in only three patients. (<i>JAMA</i>240:1260-1262, 1978)
Childhood Cancer in the Offspring of Male Sawmill Workers Occupationally Exposed to Chlorophenate Fungicides
Authors: Helen Heacock, Clyde Hertzman, Paul A. Demers, Richard Gallagher, Robert S. Hogg, Kay Teschke, Ruth Hershler, Chris D. Bajdik, Helen Dimich-Ward, Stephen A. Marion, Aleck Ostry, Shona Kelly
Journal: Environmental Health Perspectives (2000)

The objective of this study was to determine whether paternal occupational exposure to chlorophenol fungicides and their dioxin contaminants is associated with childhood cancer in the offspring of sawmill workers. We used data from 23,829 British Columbian sawmill workers employed for at least 1 continuous year between 1950 and 1985 in 11 sawmills that used chlorophenates. Probabilistic linkage of the sawmill worker cohort to the provincial marriage and birth files produced an offspring cohort of 19,674 children born at least 1 year after the initiation of employment in the period 1952-1988. We then linked the offspring cohort to the British Columbia Cancer Registry. We included all malignancies in cases younger than 20 years of age that appeared on the cancer registry between 1969 and 1993. We calculated standardized incidence ratios (SIRs) using the British Columbia population as a reference. A nested case-control analysis assessed the effects of paternal cumulative exposure and windows of exposure on the risk of developing cancer in the offspring. We identified 40 cases of cancer during 259,919 person-years of follow-up. The all-cancer SIR was 1.0 [95% confidence interval (CI), 0.7-1.4]; the SIR for leukemia was 1.0 (CI, 0.5-1.8); and the SIR for brain cancer was 1.3 (CI, 0.6-2.5). The nested case-control analysis showed slightly increased risks in the highest categories of chlorophenol exposure, although none was statistically significant. Our analyses provide little evidence to support a relationship between the risk of childhood cancer and paternal occupational exposure to chlorophenate fungicides in British Columbian sawmills.
Answer is still out regarding BCG's possible anticancer role
Authors: P. Gunby
Journal: JAMA (1982)

Bacillus of Calmette-Guérin (BCG) vaccine's possible role in the prophylaxis of some cancers is no less controversial than its longtime use in the attempt to prevent tuberculosis. The most recent forum to address the BCG-againstcancer question was the Seventh Chicago Cancer Symposium, sponsored by the Institute for Tuberculosis Research (ITR) of the University of Illinois at Chicago, the International BCG Committee, and the Illinois Cancer Council. The attenuated (BCG) strain of<i>Mycobacterium bovis</i>prepared by French scientists Albert Calmette and Camille Guérin first was administered to a human in Paris in May 1921. But controversy developed after that as a series of studies over the years produced varying results, indicating that BCG's protective efficacy against tuberculosis was not always great. Contamination of the vaccine with the virulent Kiel strain of<i>Mycobacterium tuberculosis</i>in a German laboratory caused 72 deaths in Lübeck in 1930, further adding to the debate (<i>Semin Oncol</i>
Erratum: The current role of MRI in differentiating multiple sclerosis from its imaging mimics
Authors: Ruth Geraldes, Olga Ciccarelli, Frederik Barkhof, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Monika Hofer, Friedemann Paul, Paolo Preziosa, Alex Rovira, Gabriele C. DeLuca, Ludwig Kappos, Tarek Yousry, Franz Fazekas, Jette Frederiksen, Claudio Gasperini, Jaume Sastre-Garriga, Nikos Evangelou
Journal: Nature Reviews Neurology (2018)
SPLENECTOMY IN SPLENIC ANEMIA AND BANTI'S DISEASE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nuclear Cardiology.
Authors: M. M Maisey
Journal: Cardiovascular Research (1994)

Nuclear Cardiology. Get access Michael M Maisey Michael M Maisey London, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 4, April 1994, Page 579, https://doi.org/10.1093/cvr/28.4.579a Published: 01 April 1994
Abstract 2019A: TLR3 facilitate breast cancer metastasis to lymph node
Authors: Odalys J. Torres-Luquis, Sulma Mohammed
Journal: Cancer Research (2019)

Abstract Tumor cells can only enter the lymphatic circulation at the interface between the invasive edge of the tumor and the adjacent host stroma that contains the lymphatic circulation. The existence of this distance barrier means that it would be unlikely for tumor cells to passively enter the lymph drainage. Instead, Toll-like receptors (TLRs) are important mediators for active migration and chemotaxis for tumor cells entry into the lymphatic drainage from the primary tumor. Here we use a microsurgical technique to collect lymph circulating tumor cells (LCTC) prior to its entry into sentinel lymph node in rat models and determine if the TLR expression induces the migration and tumor progression. In our results, we observed high levels of TLR3 expression in LCTC when cells were treated with Poly (I:C), a synthetic ligand for TLR3 induction. NFkB activation was also observed in LCTCs, after TLR3 activation this pathway can express genes involved in cancer progression. In addition, when looking at the expression of cytokines and chemokines factors present in the lymph or secreted by the tumor cells, CXCL10 had a high expression on induced TLR3 of LCTC and its ligand CXCR3 was also expressed in the lymph. CXCL10 is involved in chemotaxis, induction of apoptosis, and regulation of cell growth. The CXCL10/CXCR3 signaling mediates paracrine interactions between tumor and stromal cells that govern leukocyte trafficking and angiogenesis. Suppression of CXCR3 or receptors signaling limits metastasis suggesting CXCR3 contributes to the metastatic process. TLR3 Knockdown prevented tumor growth and metastasis in rat. Our data suggest that for breast cancer metastasis, TLR3 might play a role in active migration of tumor cells and tumor progression. Activation of TLRs in tumor cells can dampen the anti-tumor functions of infiltrating immune cells, altering the inflammatory response and promoting cancer progression. Citation Format: Odalys J. Torres-Luquis, Sulma Mohammed. TLR3 facilitate breast cancer metastasis to lymph node [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2019A.
Multiple epiphyseal dysplasia. A family case report
Authors: H. R. Mena
Journal: JAMA (1976)

Six cases of multiple epiphyseal dysplasia were found in a 30-member kindred. The kindred showed an increased incidence of other joint abnormalities. A dominant pattern of inheritance was not confirmed. (<i>JAMA</i>236:2629-2633, 1976)