tbuckley/cabot-search huggingface dataset:
Id: II. Method of Teaching Preventive Pediatrics in Medical School Curriculum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P05.54 Meningioma surgery in the elderly, a retrospective population based registry study
Authors: D Löfgren, M Olivecrona
Journal: Neuro-Oncology (2018)

Meningioma surgery is often considered, even at a high age, and is regarded an acceptable practice in patients without severe health problems even though there is much that is not yet known about the perioperative morbidity and mortality. Since the start 1999 the Swedish brain tumor registry has collected data on a national level. It is accepted as population based and has demonstrated good coverage. In the registry perioperative parameters such as newly diagnosed epilepsy, new focal neurological deficit, thromboembolism and date of death can be found. We have collected retrospective data from the registry to perform a population based study of the perioperative period. Included are patients with meningioma at age 65 and older from regions with a high enough coverage of registration and with surgery dates from 1999 to 2015. Two diagnose groups were made (grade I and grade II+III) as suggested by the Swedish National Brain Tumor Trialist Group. Excluded are patients in the registry that have not undergone surgery, where surgery (or not) cannot be determined and where data on complications is unavailable. 1109 patients were included (female 67,1%, male 32,9%). Median age was 72 (range 65–90) with an even gender distribution. Most patients had grade I meningioma (88,6%, female 91,0%, male 83,8%; p<0,001) with an even age distribution. 14,1% (female 15,4%, male 11,5%, NS) had WHO-PS >2, rising with age (Age>80, 28,9%, p<0,001). Perioperative mortality was 3,6% (male 4,7%, female 3,1%; NS) but clearly higher within the older age-groups (Age 65-69 1,4%; 70-74 3,3%; 75-79 4,6%; >80 7,7%; p=0,004). In the gradeII-III group mortality was significantly higher 8,7% (p<0,001) then the gradeI group and there is a statistical correlation between a WHO-PS >2 and perioperative mortality (0–2=2,8%, 3–4=7,9%; p=0,002). 28,3% (male 33,4%, female 25,8%; p=0,008) had perioperative complications (other than death), with an even age distribution. As with mortality there is a correlation with tumor grade (grI 26,8%, grII-III 40,5%; p=0,001) and there is a correlation with WHO-PS >2 (0-2 25,7%, 3-4 40,8%; p<0,001). Surgery 1999–2007 is associated with less complications (1999-2007 16,4%, 2007-2015 37,5%; p<0,001) but not with less mortality. The most common complications were hematoma and neurologic deficit (14,3% and 13,6%; NS), both evenly distributed by gender and age group. Our data shows similar perioperative mortality with published data. The risk of perioperative death is higher with rising age and a bad performancestatus correlates with a higher risk of both perioperative death and complications. The high rate of WHO-PS >2 might be a contributing factor to the high rates of perioperative morbidity as compared with published material. This data suggests caution when operating on elderly patients, especially older than 75 and with compromised performancestatus.
PATHOLOGY OF TABES DORSALIS AND GENERAL PARALYSIS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantification of aortic regurgitation (AR) from mitral and aortic (Ao) stroke volumes measured using a three-dimensional (3D) digital color doppler method in a chronic animal model Jong-Soo Lee, Michael Jones, Paul R. Detmer, Xiang-Ning Li, Rosemary A. Rusk, Xiaokui Li, David J. Sahn. Oregon Health Sciences University, Portland
Journal: Journal of the American College of Cardiology (2001)
Occupational Disease Surveillance: Asthma
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ENURESIS
Authors: JOSEPH K. CALVIN
Journal: JAMA (1928)

So much has been written about the subject of enuresis that it might seem superfluous to elaborate on it further. However, the most valuable contributions have appeared in psychologic and mental hygiene journals which, as a rule, are not read by the general practitioner, who depends on the regular medical periodicals for information. Yet it is the general practitioner, not the psychologist or psychiatrist, who must treat most of the cases of enuresis. This article is an attempt to supply the missing link and to correlate the physical and psychic aspects of the problem. Such statements as the following certainly indicate that the medical profession still considers the condition a bugaboo. Davison<sup>1</sup>says, "Much has been written but relatively little known of the condition which distresses mothers, shames children and frequently baffles physicians." Woolley,<sup>2</sup>a children's psychologist, states that "many pediatricians feel quite hopeless about cases of enuresis
Abstract B34: CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression
Authors: Linna Li, Mohit Hulsurkar, Robert Amato, Jeffrey Chang, Guangwei Du, Wenliang Li
Journal: Cancer Research (2016)

Abstract The epithelial-mesenchymal transition (EMT) confers mesenchymal properties on epithelial cells and has been closely associated with the acquisition of aggressive traits by epithelial cancer cells. To identify novel regulators of EMT, we carried out cDNA screens that covered 500 human kinases. Subsequent characterization of candidate kinases led us to uncover cyclin-dependent kinase-like 2 (CDKL2) as a novel potent promoter for EMT and breast cancer progression. CDKL2-expressing human mammary gland epithelial cells displayed enhanced mesenchymal traits and stem cell-like phenotypes, which was acquired through activating a ZEB1/E-cadherin/beta-catenin positive feedback loop and regulating CD44 mRNA alternative splicing to promote conversion of CD24-high cells to CD44-high cells. Furthermore, CDKL2 enhanced primary tumor formation and metastasis in a breast cancer xenograft model. Notably, CDKL2 is expressed significantly higher in mesenchymal human breast cancer cell lines than in epithelial lines, and its over-expression/amplification in human breast cancers is associated with shorter disease-free survival. Taken together, our study uncovered a major role for CDKL2 in promoting EMT and breast cancer progression. Citation Format: Linna Li, Mohit Hulsurkar, Robert Amato, Jeffrey Chang, Guangwei Du, Wenliang Li. CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B34.
RECOVERY FROM CYANIDE POISONING
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Authors: C Elmer, P Bartholemew, A Lapworth, P Turner, C Kelly, J Peat, B Toelle, G Marks, C Mellis
Journal: Thorax (2002)

Tattersfield et al 1 and Walsh et al 2 offer important information about the possible adverse affects of corticosteroids on bone mineral density (BMD).Tattersfield and her colleagues reported no change in BMD with inhaled corticosteroids for mild asthma, while Walsh et al found a dose related increase in the incidence of fractures in those taking oral corticosteroids.We would like to report our study of BMD in patients with airways disease, which reinforces these findings and highlights men as being particularly at risk.We prospectively studied 100 consecutive outpatients (44 men) with steroid responsive airways disease.The formulation and cumulative dose of corticosteroid was recorded in each individual, together with all prescribed prophylaxis for osteoporosis.Bone mineral density was measured in the non-dominant forearm.We found no relationship between inhaled corticosteroid dose and BMD.Mean BMD was significantly reduced in those on oral as opposed to inhaled steroids.In men the mean Z scores for those on inhaled and oral corticosteroids were 0.1 and -0.6, respectively (p=0.07), while women had mean Z scores of 0.5 and -0.3 for inhaled and oral corticosteroids, respectively (p=0.016).Our patient numbers were insufficient to confirm a dose response.The surprising result was that men were more likely to meet the WHO criteria for osteoporosis than women (25% v 12.5%).This result is explained at least in part by the use of prophylaxis which was prescribed to 21 women but to only two men.Of those on regular oral steroids, only 5.5% of men received prophylaxis compared with 62.5% of women.Similar results have been reported in other chronic diseases, with a greater reduction in BMD being reported in men with cystic fibrosis. 3 Unfortunately it appears to have been assumed that men are protected from osteoporosis by virtue of their gender.When chronic disease is treated with oral corticosteroids, both men and women are equally at risk of osteoporosis and all should be considered for prophylaxis.
Localization Of Parathyroid Glands
Authors: K. Levin
Journal: Annual Review of Medicine (1988)

Parathyroid localization tests are helpful for all patients with primary hyperparathyroidism before parathyroid exploration, and they are essential for patients who have had previous parathyroid or thyroid operations. The selection of specific localization tests depends on whether the patient is undergoing an initial or a reoperative procedure, as well as on the availability of the specialized equipment and expertise of the physicians and technicians performing and interpreting these studies.
American College of Physicians Guidelines on Cholesterol Screening
Authors: Edward J. Kryshak
Journal: Annals of Internal Medicine (1996)

Letters15 December 1996American College of Physicians Guidelines on Cholesterol ScreeningEdward J. Kryshak, MDEdward J. Kryshak, MDSpringfield Clinic, Springfield, MO 65807.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-12-199612150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The paper on lipid screening by the American College of Physicians [1] is thought-provoking yet disappointing. The recommendations for limited screening for lipid disorders in young adults eliminates an important impetus (similar to that provided by plasma glucose levels and blood pressure) for positive lifestyle changes by young patients. Despite the lack of definitive population studies done in persons 20 to 45 years of age, an individual patient's knowledge of his or her own lipid levels and the lipid changes that are seen as a result of lifestyle changes can be used to strongly reinforce healthy lifestyle ...REFERENCE1. American College of Physicians. Guidelines for using serum cholesterol, high-density lipoprotein cholesterol, and triglyceride levels as screening tests for preventing coronary heart disease in adults. Ann Intern Med. 1996; 124:515-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: Springfield Clinic, Springfield, MO 65807. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1996Volume 125, Issue 12Page: 1008KeywordsBlood plasmaFearForecastingGlucoseLipid disordersLipid screeningLipidsPatient advocacyScreening guidelinesYoung adults Issue Published: 15 December 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Impact of baseline hepatitis B viremia and management on outcomes in advanced hepatocellular carcinoma and elevated alpha-fetoprotein: outcomes from REACH-2
Authors: Peter Galle, Masatoshi Kudo, Josep M. Llovet, Richard Finn, Mark Karwal, Pezet Denis, Tae-You Kim, Tsai-Sheng Yang, Vittorina Zagonel, Jiri Tomasek, Jean-Marc Phelip, Yann Touchefeu, Su-Jin Koh, Guido Stirnimann, Chunxiao Wang, Kenyon Ogburn, Paolo B. Abada, Ryan Widau, Andrew Zhu
Journal: Journal of Hepatology (2020)
PD-1 blockade in tumors with mismatch repair deficiency.
Authors: Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne Bartlett, Holly Kemberling, Aleksandra Eyring, Andrew Skora, Nilofer Saba Azad, Daniel A. Laheru, Ross C. Donehower, Brandon Luber, Todd S. Crocenzi, George A. Fisher, Steve M Duffy, James J. Lee, Minori Koshiji, James R. Eshleman, Robert A Anders, Bert Vogelstein, Luis A. Diaz
Journal: Journal of Clinical Oncology (2015)

LBA100 The full, final text of this abstract will be available at abstracts.asco.org at 2:00 PM (EDT) on Friday, May 29, 2015, and in the Annual Meeting Proceedings online supplement to the June 20, 2015, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.
Parallel 26: Hepatotoxicity: Pathogenesis and Mechanisms
Authors: Arun Sanyal, Robert Figler, Brett Blackman, Svetlana Marukian, Sol Collado, Mark Lawson, Aaron Mackey, David Manka, Brian Wamhoff, Ajit Dash, Marc Bilodeau, Grégory Merlen, Benoit Lacoste, Benoît Dupont, Valérie-Ann Raymond
Journal: Hepatology (2015)
Myocardial infarction, presumably embolic. Late complication of prosthetic-valve surgery
Authors: B. L. London
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improved Trichrome Method for Rapid Diagnosis for Fresh-Frozen Biopsy Sections
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
JAMA Instructions for Authors
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maternal alcohol consumption and birth weight. How much drinking during pregnancy is safe?
Authors: J. L. Mills
Journal: JAMA (1984)

The relationship between maternal alcohol drinking during pregnancy and birth weight was examined using prospectively collected data from 31,604 pregnancies. The percentage of newborns below the tenth percentile of weight for gestational age increased sharply with increasing alcohol intake. After adjustment for other risks, a reduction in mean birth weight was seen in drinkers compared with nondrinkers, ranging from 14 g in those drinking less than one drink each day to 165 g in those drinking three to five drinks each day. The adjusted odds ratio for producing a small-for-dates newborn compared with nondrinkers ranged from 1.11 in those drinking less than one drink daily to 1.96 in those drinking three to five drinks daily. Consuming at least one to two drinks daily was associated with a substantially increased risk of producing a growth-retarded infant. Conversely, consuming less than one drink daily had a minimal effect on intrauterine growth and birth weight. (<i>JAMA</i>1984;252:1875-1879)
The effect of terbutaline on cardiac function in patients with stable chronic obstructive lung disease
Authors: E. V. Sunderrajan
Journal: JAMA (1983)

The effect of 0.25 mg of terbutaline sulfate, a β<sub>2</sub>-adrenergic agent, on the right and left ventricular ejection fractions (RVEF and LVEF, respectively) was studied in 30 patients with severe stable chronic obstructive pulmonary disease (COPD) with a mean forced expiratory volume in 1 s of 0.79±0.06 L. All bronchodilator therapy was withdrawn 48 hours before the study. The ECG-synchronized gated equilibrium radionuclide ventriculography showed decreased RVEF in 27 patients and LVEF in 16 patients. Both the RVEF and LVEF significantly increased after the terbutaline injection; this increase was noted both in patients with normal and decreased ejection fractions. We conclude that the increase in ejection fractions after terbutaline injection may contribute to the good clinical response to this drug seen in patients with severe stable COPD even though the bronchodilator effect may be minimal. (<i>JAMA</i>1983;250:2151-2156)