tbuckley/cabot-search huggingface dataset:
Molecular Biology of Keratinocyte Differentiation
Authors: Richard Leon Eckert, Ellen Anne Rorke
Journal: Environmental Health Perspectives (1989)

Epidermal keratinocytes (skin cells) are highly specialized epithelial cells designed to perform a very specific function, separation of the organism from its environment. To accomplish this the cells synthesize precursors and assemble them into two distinct structures, the cornified envelope and keratin intermediate filaments. The intermediate filaments are assembled from keratin monomers and the cornified envelope is assembled from a protein called involucrin and several other proteins. Expression of involucrin and the keratins genes are regulated as a function of the stage of keratinocyte differentiation and by various external agents such as calcium and vitamin A. To study the function of these structures and the regulation of precursor production we have cloned cDNA and genomic clones encoding involucrin and four of the keratin polypeptides. Retinoids profoundly alter the differentiation pattern of human epidermal keratinocytes, but the underlying biochemical basis of this change is not known. In this report we describe retinoid-promoted changes in keratin gene expression that may, in part, be responsible for the alteration in cellular phenotype in the presence of the vitamin. We also describe the novel structure of the human 40 kD keratin, a member of the keratin family that is retinoid responsive and is likely to be important during epidermal development. Finally, we describe the structure of the envelope precursor protein, involucrin, as determined from its DNA sequence and speculate on its role in cornified envelope formation.
Hugh Bannerman
Journal: BMJ (2005)

Psychiatrist who reinterpreted the Royal Free fatigue epidemic and wrote historical atlases Colin McEvedy was interested in mass movements of people, whether as a psychiatrist, historian, or demographer, but it was his analysis of a mystery illness at the Royal Free Hospital in London that made his name in psychiatry.In 1955 an epidemic swept through the nursing staff at the Royal Free, closing the hospital for three months.In all, 300 people were affected, 200 of whom were admitted.No one died and not one single hospital patient was affected, and no causative organism was ever found, though not for want of looking.The disease was described as a benign, myalgic form of encephalomyelitis.Fifteen years later, Colin McEvedy, then a senior registrar at the Middlesex Hospital, co-wrote two papers (with his boss, Professor Bill Beard), arguing, firstly, that the epidemic was one of conversion hysteria triggered by fear, probably of polio (BMJ 1970;1(687):7-11), which was still a serious problem at the time; and, secondly, that it was one of several reported similar epidemics, others of which were among hospital nurses (BMJ 1970;1(687):11-15).McEvedy was meanwhile writing a thesis on two epidemics of mass hysteria in girls' schools.His doctoral thesis was accepted without difficulty, but the papers on the Royal Free outbreak were greeted with howls of rage.Although he and Beard emphasised that the diagnosis of hysteria was "not a slur on the individuals or the institution involved" and that "the hysterical reaction is part of everyone's potential," many people, it seemed, felt that while hysteria was an acceptable diagnosis in the case of schoolgirls, it was not in the case of nurses.McEvedy and Beard's argument was that, in addition to the absence of an identifiable causative organism, most people recovered unremarkably, and most biochemical tests were normal.Most sufferers had depression, fatigue, and vague neurological signs.Many had paralysis or sensory disturbances, but their reflexes were normal.Taking the institution as a wholestaff, students, and patients-the epidemic affected 10.4% of women and only 2.8% of men.Two sufferers who died from other causes (ovarian cancer, disseminated
324P Radiation response assessment by hybrid positron emission tomography/magnetic resonance imaging for cervical cancer treatment
Authors: B.A. Choo, V. Koh, J. Tang, J. Low, M.C. Stephenson, D.L-H. Cheong, E. Laurens, J.J. Totman, J.S-Y. Ng, S. Roy
Journal: Annals of Oncology (2016)
Erratum: “Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice”
Authors: Riann Jenay Egusquiza, Maria Elena Ambrosio, Shuyi Gin Wang, Kaelen Marie Kay, Chunyun Zhang, Hans-Joachim Lehmler, Bruce Blumberg
Journal: Environmental Health Perspectives (2020)
Abstract 313: AXL confers intrinsic resistance to osimertinib and the emergence of tolerant cells
Authors: Hirokazu Taniguchi, Tadaaki Yamada, Rong Wang, Keiko Tanimura, Akihiro Nishiyama, Azusa Tanimoto, Yuta Adachi, Shinji Takeuchi, Hiroyuki Yamaguchi, Minoru Fukuda, Koichi Takayama, Hiroshi Mukae, Seiji Yano
Journal: Cancer Research (2019)

Abstract A novel EGFR-tyrosine kinase inhibitor (TKI), osimertinib, has marked efficacy in patients with EGFR-mutated lung cancer. However, some patients show intrinsic resistance and an insufficient response to osimertinib. This study showed that osimertinib adversely stimulated AXL by inhibiting a negative feedback loop. Activated AXL was associated with EGFR and HER3 in maintaining cell survival and inducing the emergence of cells tolerant to osimertinib. AXL inhibition reduced the viability of EGFR-mutated lung cancer cells overexpressing AXL that were exposed to osimertinib. The addition of an AXL inhibitor during either the initial or tolerant phases reduced tumor size and delayed tumor re-growth compared to osimertinib alone. AXL was highly expressed in clinical specimens of EGFR-mutated lung cancers and its high expression was associated with a low response rate to EGFR-TKI. These results indicated pivotal roles for AXL and its inhibition in the intrinsic resistance to osimertinib and the emergence of osimertinib-tolerant cells. Citation Format: Hirokazu Taniguchi, Tadaaki Yamada, Rong Wang, Keiko Tanimura, Akihiro Nishiyama, Azusa Tanimoto, Yuta Adachi, Shinji Takeuchi, Hiroyuki Yamaguchi, Minoru Fukuda, Koichi Takayama, Hiroshi Mukae, Seiji Yano. AXL confers intrinsic resistance to osimertinib and the emergence of tolerant cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 313.
Chemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on Carcinogens
Journal: Environmental Health Perspectives (1986)

In order to articulate a view of chemical carcinogenesis that scientists generally hold in common today and to draw upon this understanding to compose guiding principles that can be used as a bases for the efforts of the regulatory agencies to establish guidelines for assessing carcinogenic risk to meet the specific requirements of the legislative acts they are charged to implement, the Office of Science and Technology Policy, Executive Office, the White House drew on the expertise of a number of regulatory agencies to elucidate present scientific views in critical areas of the major disciplines important to the process of risk assessment.The document is composed of two major sections, Principles and the State-of-the-Science.The latter consists of subsections on the mechanisms of carcinogenesis, short-term and long-term testing, and epi- demiology, which are important components in the risk assessment step of hazard identification.These subsections are followed by one on exposure assessment, and a final section which includes analyses of dose-response (hazard) assessment and risk characterization.The principles are derived from considerations in each of the subsections.Because of present gaps in understanding, the principles contain judgmental (science policy) decisions on major unresolved issues as well as statements of what is generally accepted as fact.These judgments are basically assumptions which are responsible for much of the uncertainty in the process of risk assessment.There was an attempt to clearly distinguish policy and fact.The subsections of the State-of-the-Science portion provide the underlying support to the principles articulated, and to read the "Principles" section without a full appreciation of the State-of-the-Science section is to invite oversimplification and misinterpretation.Finally, suggestions are made for future research efforts which will improve the process of risk as- sessment.
PLAGUE TREATMENT BY CARBOLIC ACID.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selective proximal vagotomy.
Authors: A Darlington, Thomas Hennessy
Journal: BMJ (1972)

contacts had no clinical or radiological evidence of disease.Two, a mother and son, developed active pulmonary tuberculosis and were treated apparently successfully with chemotherapy and discharged from the chest unit as cured years before their deaths.Five cases of disseminated sclerosis over the years, though a fairly high percentage of my list, admittedly can prove nothing, but in my opinion they are suggestive of more than just coincidence.I think it likely that the vigorous immune reaction against a massive tubercular onslaught is directed against the lipoids of the tubercle bacillus and, having achieved its object, goes on to attack the myelin of the central nervous system, which has a similar chemical com- position.-Iam, etc.,
JUSTIFIABLE SUMPTUARY LEGISLATION.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid diagnosis of bacteremia with quantitative differential-membrane filtration culture
Authors: W. R. Winn
Journal: JAMA (1966)

In 13 cases of bacteremia, rapid bacteriological diagnosis was made through membrane filtration of extracellular organisms. Colonies isolated by filtration can be quickly identified with certain rapid tests. Blood may be processed so that extracellular bacteremia can be quantitatively distinguished from intraleukocytic and erythrocyte-associated infection. The importance of expediting diagnosis of bacteremia is discussed in the context of occurrence of serious bacterial infection in this antibiotic era.
THE PUBLIC SERVICE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The several Cs of translational clinical research
Authors: David G. Nathan
Journal: Journal of Clinical Investigation (2005)

Perhaps because I am a veteran of the “good old days” (they were really quite bad), young physicians who hope to become clinical investigators often ask me how they might establish their careers. Many are more than a little worried about their futures and often have trouble envisioning a career path that is financially secure for themselves and their families. The grumbling of clinical investigators a few years their senior enhances their angst. So I try to encourage these young physicians because I know the great intellectual (if not monetary) rewards of the field and because I know that the future of medicine absolutely depends on clinical investigators. The following is what I try to say to them.
Dementia
Authors: PEGGY HANSEN
Journal: Annals of Internal Medicine (1984)

Ad Libitum1 October 1984DementiaPEGGY HANSENPEGGY HANSENSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-558_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptJune—no, it's not quite right for Junealthough it's coming on to it,I can't tell how.I had a feelingthat I knew you somewhere, before,when I knew thingswhen I could dance and flirtand laugh like any girlblazing with identity;before I lost my namein all these cloudsconfusing friend and stranger.your face could be familiar:a classmate years ago,a doctor, a priest—all these have gone, and more.you say we have not metand I am powerless,beyond any endto this mad anguish.now you ask what day it... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1984Volume 101, Issue 4Page: 558-558KeywordsDementiaEmotions Issue Published: 1 October 1984 PDF downloadLoading ...
High Prevalence of Iron Deficiency Anemia Among Alaskan Native Children
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-014 Clinical and Endoscopic Improvement following Hemopoietic Stem Cell Transplantation vs Mobilisatiion alone in Crohn’S Disease
Authors: C Hawkey, M Allez, S Ardizzone, L Clark, J-F Columbel, S Danese, D Farge-Bancel, M Labopin, J Lindsay, A Norman, F Onida, E Ricart, G Rogler, M Rovira, N Russell, J Satsangi, S Travis, A Tyndall, S Vermeire
Journal: Gut (2013)

<h3>Introduction</h3> The Autologous Stem Cell Transplantation International Crohn’s Disease (ASTIC) Trial is a randomised controlled trial co-sponsored by ECCO and EBMT and funded by the Broad Foundation that investigates immunoablation and hemopoietic stem cell transplantation (HSCT) in Crohn’s disease (CD) over 1 year: all patients will have reached this endpoint by April 2013. <h3>Methods</h3> Patients with impaired quality of life due to active CD, despite ≥ 3 immunosuppressive agents all underwent mobilisation (iv cyclophosphamide 4 gm/M2 over 2 days then filgrastim10µ/kg/day) before randomisation to immediate (1 month) or delayed (13 months) HSCT. The conditioning regime was iv cyclophosphamide 50mg/kg per day for 4 days, anti-thymocyte globulin 2.5 mg/kg/day and methyl prednisolone 1mg/kg on days 3–5. The bone marrow was reconstituted by infusion of an unselected graft of 3–8 × 106/kg CD34 +ve stem cells. Clinical (CDAI), endoscopic (SES-CD) quality of life and safety data are compared 1 year after mobilisation alone or after mobilisation and HSCT. <h3>Results</h3> As of Jan 2013, data are available on 34/45 patients. Following mobilisation and HSCT, the CDAI fell from 317 (median, IQR 244–407) to 157 (71–246, n = 17) vs 351 (313–446) and 298 (220–370, n = 17) with mobilisation alone. The aggregate lower GI SES-CD score was 13.0 (8.5–24.5) before and 3.0 (1.5–10.0) after HSCT compared to 13.0 (6.5–15.5) before and 6.5 (3.5–17.8) after mobilisation alone. Over the whole study to end 2012 there were 62 SAEs in 19 patients randomised to early transplantation (3.3 per patient) and 58 in 18 patients randomised to delayed transplantation (3.2 per patient). One patient died following HSCT. Final results of the study will be available to be presented for the first time at BSG 2013. <h3>Conclusion</h3> Immunoablation and HSCT appears to be an effective treatment for CD that may substantially reduce endoscopic evidence of disease but incurs significant toxicity. The final results of the trial will allow a rational evaluation of the effectiveness and safety of HSCT to be discussed at BSG 2013. <h3>Disclosure of Interest</h3> None Declared
Gastrointestinal bleeding
Authors: L. Cipolletta, G. Rotondano, M. Bianco
Journal: Endoscopy (2007)

This epidemiologic survey focused on two university hospitals and 12 regional hospitals around Amsterdam, in which 14 % of patients admitted with hematemesis, melena, or hematochezia, or who developed peptic ulcer bleeding as inpatients, died. Mortality rate was nearly double the mortality rate of 5 - 8 % reported by specialized units that emphasize prompt resuscitation, early endoscopic diagnosis, and treatment followed by dedicated multidisciplinary postoperative care [1] [2]. Also, the 19 % recurrent bleeding rate and 7 % need for surgery rate are higher than rates reported elsewhere, and no doubt contributed to the overall mortality.
Abstracts
Journal: Thorax (1953)

In 10% of cases of oesophageal atresia the distal end of the oesophagus may be agenetic or hypoplastic, there being no evidence of the more usual tracheal or bronchial fistulous communication.The key to diagnosis in this type of oesophageal abnormality is the failure to demonstrate by radiological means the presence of intestinal air.The author considers primary restoration of the continuity of the alimentary canal to be the ideal surgical treatment and describes his management of such a case.A premature female infant from birth suffered from attacks of cyanosis after each feed, and excessive oro- nasal secretion was noted.Lipiodol introduced by catheter demonstrated a blind upper end to the oesophagus and in plain radiographs there was an absence of gas shadows.On the third day of life a right transpleural oesophago-cardiostomy was performed.The operative procedure is well illustrated.Division of the left gastric vessels permitted adequate mobilization of the stomach for this anastomosis.The surgical treatment, of nearly 4 hours' duration, was well tolerated, but the child died from increasing attacks of cyanosis 26 hours later.Other congenital abnormalities were present.C. A. Jackson.
Tragic Loss of Leaders in AIDS and Public Health
Authors: R. Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal