tbuckley/cabot-search huggingface dataset:
GENEVA
Journal: JAMA (1926)

<h3>Treatment of Gout</h3> For the last three years the Geneva school has devoted much time to the study of blood dilution in gout. Increase in hydremia causes an acute outburst of the process. Effective prophylactic and therapeutic measures are those which increase the viscosity of the blood. In the treatment of gout the degree of blood dilution, measured by the degree of viscosity, or by any other means, should be ascertained. Furthermore, in a hyperuricemic gouty subject a course of diuretics or alkaline medication (vichy and similar waters) will not cause acute phenomena and therefore may be resorted to without reserve. In the hyperuricemic gouty subject with normal or subnormal viscosity, any treatment must be closely followed in order to prevent an acute outburst. With a dry diet and large amounts of sugar, combined with aperients, the blood viscosity can rapidly be increased. This is the most effective treatment to
'Silent epidemic' of 'social disease' makes STD experts raise their voices
Authors: M. F. Goldsmith
Journal: JAMA (1989)

IMMUNOLOGICAL VIRGINS seem to be almost the only kind one finds among adolescents anymore, and that fact may in part account for the tremendous increase in sexually transmitted diseases (STDs) in the United States. At a symposium in New York City on "The 'Other' STDs: A Silent Epidemic," sponsored by the American Medical Association and the Centers for Disease Control (CDC), Atlanta, Ga, authorities who have worked on stopping STD spread for years said the situation is now nearly out of control. ("Other" recognizes that acquired immunodeficiency syndrome [AIDS] has become the overwhelming concern, leaving different STDs in the shade. The meeting was supported by a grant from Burroughs Wellcome Company.) A major reason for STD increase is that young people are being exposed to infection, and acquisition is often rapid and asymptomatic. A great many of the more than 70% of people who are sexually active by age 19
Differential activity of PARP inhibitors in <i>BRCA1</i>- versus <i>BRCA2</i>-altered metastatic castration-resistant prostate cancer (mCRPC).
Authors: Fadi Taza, Albert E Holler, Nabil Adra, Ryan Ashkar, Alexandra Sokolova, Adam Kessel, Nellie Nafissi, Pedro C. Barata, Diogo Assed Bastos, Oren Smaletz, Rahul Raj Aggarwal, Jacob E Berchuck, Panagiotis J. Vlachostergios, Christopher Su, Catherine Handy Marshall, Emmanuel S. Antonarakis
Journal: Journal of Clinical Oncology (2021)

100 Background: Two PARP inhibitors (olaparib, rucaparib) are now FDA approved for mCRPC patients with mutations in BRCA1/2, but the relative efficacy of PARP inhibition in BRCA1- vs BRCA2-altered mCRPC is understudied. Methods: We conducted a multi-center retrospective analysis involving 11 academic sites. We collected genomic and clinical data from 123 BRCA1/2-altered mCRPC patients receiving PARP inhibitor treatment. The primary efficacy endpoint was PSA50 response rate (≥50% decline in PSA level). Secondary endpoints were PFS (clinical, radiographic or PSA progression, whichever occurred first) and overall survival (OS). We also captured information on other concurrent genomic alterations. We compared genomic characteristics and clinical outcomes among BRCA1- vs BRCA2-altered mCRPC. Results: A total of 123 patients (13 BRCA1, 110 BRCA2) were included. PARP inhibitors used were olaparib (n = 116), rucaparib (n = 3), talazoparib (n = 2) and veliparib (n = 2). All BRCA1 and 71% of BRCA2 patients had Gleason 8-10 disease. Compared to BRCA2 patients, BRCA1 patients were more likely to have received prior taxane chemotherapy (77% vs 62%). Age, baseline PSA, and prior enzalutamide/abiraterone treatment were similar between groups. PSA50 responses in BRCA1- vs BRCA2-altered patients were 38% vs 65% respectively ( P= 0.06). Median PFS in BRCA1 vs BRCA2 patients was 3.0 mo (95%CI, 0.9–5.1) vs 8.0 mo (95%CI, 5.3–10.6) respectively (HR 0.42, P= 0.01). Similarly, median OS in BRCA1 vs BRCA2 patients was 11.0 mo (95%CI, 9.9–12.1) vs 24.0 mo (95%CI, 18.2–29.8) respectively (HR 0.33, P= 0.005). There were roughly equal proportions of germline mutations (50% vs 45%) and biallelic mutations (31% vs 25%) in the BRCA2 and BRCA1 groups, respectively. There were numerically more TP53 mutations in the BRCA1 vs BRCA2 group (40% vs 29%, P= 0.45), but an equal number of mutations in other key genes ( PTEN, RB1 and AR). Conclusions: PARP inhibitor activity is diminished in BRCA1- vs BRCA2-altered mCRPC. In our cohort, this differential activity was not explained by mutation origin (germline vs somatic) or allelic status (mono- vs biallelic). These findings warrant validation.
Digital Computers: What They Are
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incomplete traumatic quadriplegia. A ten-year review
Authors: A. Bosch
Journal: JAMA (1971)

Incomplete quadriplegia following closed injuries to the cervical spine is studied for future prognosis of this increasingly common lesion. Sixty patients were included in this study and classified into one of four clinical syndromes to correlate the different types of quadriplegia to its final outcome. Interest was focused primarily in the return of function to the lower and upper extremities and to rectal and bladder control. This communication concentrates on two major groups—the central spinal cord syndrome and the anterior spinal cord syndrome which, combined, represent 90% of our series. An ambulation follow-up comparison is made of central cord syndrome and anterior cord syndrome. A more accurate prognosis of cervical cord lesions can be established on a statistical basis.
Molecular and genomic characterization of invasive circulating tumor cells (iCTCs) from men with metastatic castration-resistant prostate cancer (mCRPC).
Authors: Terence W. Friedlander, Gayatri Premasekharan, Vy Ngo, Evelyn Hang, Julie Nicole Graff, Charles J. Ryan, Pamela Paris
Journal: Journal of Clinical Oncology (2014)

11013 Background: Molecular characterization and genomic analysis of CTCs may allow for a better understanding of the mechanisms of resistance to therapies in metastatic castration-resistant prostate cancer (mCRPC). The Vitatex VitaAssay platform captures invasive CTCs (iCTCs) in a cell surface marker-independent fashion based on their ability to invade a fluorescently-labeled cell-adhesion matrix (CAM), allowing for the analysis of multiple CTC subpopulations. Here we sought to estimate epithelial, mesenchymal, and stem-like iCTC subpopulation diversity in men with CRPC starting abiraterone acetate therapy, to compare the genomic profiles of iCTCs to matched metastatic biopsies, and to explore the potential for 2D and 3D CTC culture. Methods: iCTCs were isolated from men with mCRPC using the CAM platform, and paired metastatic biopsies were performed. iCTCs were defined as CAM+/CD45-/CD14-/DAPI+, mesenchymal iCTCs as vimentin+/CAM+/CD45-/CD14-/DAPI+, and stem-like iCTCs as CD44+/CAM+/CD45-/CD14-/DAPI+. iCTCs were enumerated and purified using FACS. Agilent array comparative genomic hybridization (aCGH) of iCTCs and paired biopsies was performed, and to explore the potential for ex-vivo cell expansion and spheroid formation, iCTCs were cultured separately in CAM and in matrigel for up to 10 days. Results: iCTCs were isolated using the CAM platform from 42 men, of whom seven have undergone paired metastatic biopsy. The median baseline iCTC count per 7.5ml was 46 (range 0-444). In a subset of 17 subjects the median baseline CD44+ iCTC count per 7.5ml was 75 (range 0-1,410), and in a subset of 5 subjects the median vimentin+ CTC count per 7.5ml was 10 (range 1-17). AR amplification is detectable in iCTCs, iCTC aCGH profiles resemble paired soft tissue biopsy, and iCTC spheroids were observed. Conclusions: Multiple CRPC iCTC subpopulations are identifiable from men starting abiraterone. iCTCs resemble metastatic CRPC tissue and can be expanded in vitro. Further enumeration, genomic profiling, and clinical correlation of serial iCTCs taken from men with mCRPC is underway, and may shed light on mechanisms of abiraterone resistance.
Nocturnal oxygen desaturation in patients with sickle cell anemia
Authors: M. B. Scharf
Journal: JAMA (1983)

The sleep of two patients with sickle cell disease was punctuated by periods with notably reduced arterial O<sub>2</sub>saturation despite simultaneous normal respiratory rates. The O<sub>2</sub>levels returned to baseline during intermittent wakefulness. Gas exchange patterns during sleep may contribute to the morbidity of sickle cell disease. (<i>JAMA</i>1983;249:1753-1755)
Tubercle, London
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heberden Society. Annual general meeting and oration. Papers.
Authors: P Bacon, J Reardon, R Bucknall
Journal: Annals of the Rheumatic Diseases (1979)

Neutropenia, a common complication in RA may be due to marrow depression or increased destruction.Current tests for marrow reserve are unpleasant and toxic.We have developed a new one based on the known granulocytophilic effect of corticosteroids.A single i.v.injection of hydrocortisone 100 mg given to a resting subject at 9 a.m.produces an increase in peripheral blood granulocytes.Preliminary studies in 5 normal subjects taking hourly samples showed that a peak response occurred at 4 hours, with an increase of over 100%, significantly higher than the normal diurnal variations in the same subjects.Repeat tests on separate occasions showed reasonable reproducibility.A dose response curve using 25, 50, 100, and 200 mg of HCO on separate occasions in 2 normal subjects showed that 100 mg
Is Pathology of Mycobacterium Tuberculosis Infections Different from Battey Strain, Group III, Nonphotochromogenic Mycobacteria?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preventive Cardiology Conference Traces Cause and Effect Phenomena
Journal: JAMA (1964)

The observation of frequently recurring physiological factors, habit patterns, and characteristics of personality among cardiac patients has led a number of investigators to evolve techniques of preventive cardiology based upon manipulation of one or more of these phenomena. However, since there is not as yet any clinical proof of a cause and effect relationship betwen any of these high frequency corollaries and ischemic heart disease (IHD ), the relative effectiveness of any scheme of prevention remains unknown and unverifiable. This was the consensus of investigators from the US, Canada, western Europe, and Australia who gathered at the University of Vermont, Burlington, in August for the first international conference on preventive cardiology. Progress in the prevention of IHD must await tangible statistical data on the long-range prophylactic effectiveness of existing programs of prevention. There is also an obvious need for further research into the biochemical pathogenesis of heart disease since one or
Ureteral Stone Management: II. Ureteroscopy and Ultrasonic Lithotripsy
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Avian Respiratory System: A Unique Model for Studies of Respiratory Toxicosis and for Monitoring Air Quality
Authors: Richard E. Brown, Joseph D. Brain, Ning Wang
Journal: Environmental Health Perspectives (1997)

There are many distinct differences (morphologic, physiologic, and mechanical) between the bird's lung-air-sac respiratory system and the mammalian bronchoalveolar lung. In this paper, we review the physiology of the avian respiratory system with attention to those mechanisms that may lead to significantly different results, relative to those in mammals, following exposure to toxic gases and airborne particulates. We suggest that these differences can be productively exploited to further our understanding of the basic mechanisms of inhalant toxicology (gases and particulates). The large mass-specific gas uptake by the avian respiratory system, at rest and especially during exercise, could be exploited as a sensitive monitor of air quality. Birds have much to offer in our understanding of respiratory toxicology, but that expectation can only be realized by investigating, in a wide variety of avian taxa, the pathophysiologic interactions of a broad range of inhaled toxicants on the bird's unique respiratory system.
Pituitary Ablation for Diabetic Retinopathy
Authors: Bronson S. Ray
Journal: JAMA (1968)

The implantation of yttrium 90 into the pituitary gland as an alternate to surgical hypophysectomy for treatment of diabetic retinopathy was employed in 22 patients whose conditions did not meet the more rigid requirements used in selecting patients for craniotomy. Complications related to the procedure developed in about half of the patients and five patients died in the period of seven weeks to 11 months as a result of these complications. Among the survivors 75% had improvement or arrest of progressive retinopathy, approximately the same as after surgical hypophysectomy. But since destruction of the pituitary gland was less certain by the use of yttrium 90, sustained benefit may prove to be less than that following surgical removal.
BLAST INJURIES
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WHAT IS AN ANTISEPTIC?
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
115MO Long-term efficacy, tolerability and overall survival in patients (pts) with unresectable or metastatic (U/M) PDGFRA D842V-mutant gastrointestinal stromal tumour (GIST) treated with avapritinib: NAVIGATOR phase I trial update
Authors: Y-K. Kang, R.L. Jones, M. von Mehren, C. Serrano, S. George, M.C. Heinrich, P. Schöffski, O. Mir, P.A. Cassier, F. Eskens, P. Rutkowski, W.D. Tap, S.P. Chawla, H. Shi, M. Roche, S. Bauer
Journal: Annals of Oncology (2020)
Neurosurgery
Authors: Lester J. Wallman
Journal: JAMA (1971)

The late Dr. Francis Grant once said that it is better to have a lucky surgeon than a good one, meaning of course that the nature of the lesion has more influence on the outcome than does the skill of the operator. It is still the case, however, that post-operative care is simpler for the surgeon who does his work well in the operating room, and his worries are less intense if he approaches the deep tissues with confidence in his methods and tools. To choose between alternate methods of management requires surgical judgment. A manual can only signal alternatives. Thus the resident and the general neurosurgeon should not try to select one book on technique but should have access to several. This reviewer likes Gurdjian,<i>Operative Neurosurgery</i>(ed 3), Kempe's 2-volume<i>Operative Neurosurgery</i>, and would add the present volume, edited by Valentine Logue. Although several North American authors are
Correction
Journal: BMJ (1920)

EDW&L JoUhI but more important is the avoidance of carrying weights' which cause a prolonged effort, as opposeq to an intermittent one on the part of the muscles.This is borne out, again, in the case of Badminton, wlichl, because of quick extension efforts very frequently repeated, accentuates the pain of a previous tennis elbow more than does a game of tennis.
Anti-DKK1 mAb (BHQ880) as a Potential Therapeutic for Multiple Myeloma.
Authors: Mariateresa Fulciniti, Pierfrancesco Tassone, Teru Hideshima, Sonia Vallet, Seth Ettenberg, David Stover, Simona Blotta, Zhenxin Shen, Maria Teresa Dimartino, Paola Neri, Rao Prabhala, Raje Nopur, Steven R. Goldring, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Blood (2007)
ORAL ABSTRACT SESSION: BASIC SCIENCE
Authors: A-S Hervent, ; Hamdani, ; Matheeussen, ; Demolder, ; De Meester, ; Wa, W Paulus, G De Keulenaer, L Vandekerckhove, T Zaglia, ; Milan, ; Ruhs, ; Kruger, ; Franzoso, ; Bertaggia, ; Pesce, ; Glass, ; Mongillo, ; Sandri
Journal: European Journal of Heart Failure (2013)