tbuckley/cabot-search huggingface dataset:
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
Authors: J. Selhub
Journal: JAMA (1993)

<h3>Objective.</h3> —To describe the distribution of plasma homocysteine concentrations in an elderly population and to analyze the relationship between homocysteine level and intake of vitamins and serum levels of vitamins that serve as coenzymes in homocysteine metabolism. <h3>Design.</h3> —Cross-sectional analysis of homocysteine levels and vitamin blood levels and intake in elderly participants in the Framingham Study. <h3>Setting.</h3> —Population-based cohort in Framingham, Mass. <h3>Participants.</h3> —A total of 1160 adult survivors, aged 67 to 96 years, from the original Framingham Heart Study cohort. <h3>Main Outcome Measures.</h3> —Plasma homocysteine concentration correlated with plasma folate, vitamin B<sub>12</sub>, pyridoxal-5'-phosphate (PLP), and oral intakes of these vitamins, and the contribution of these vitamins to the prevalence of elevated homocysteine in the population. <h3>Results.</h3> —Homocysteine levels were positively correlated with age after controlling for vitamin concentrations. After controlling for age, sex, and levels of other vitamins, homocysteine exhibited a strong inverse association with plasma folate. When subjects were grouped by deciles of plasma folate, mean homocysteine was significantly higher in the lowest two folate deciles (15.6 and 13.7 μmol/L, respectively) than in the highest decile (11.0 μmol/L). Homocysteine demonstrated weaker, inverse associations with plasma vitamin B<sub>12</sub>and PLP. Similar inverse associations were demonstrated between homocysteine and intakes of folate and vitamin B<sub>6</sub>, but not vitamin B<sub>12</sub>. Prevalence of high homocysteine (&gt;14 μmol/L) was 29.3% in this cohort, and was greatest among subjects with low folate status. Inadequate plasma concentrations of one or more B vitamins appear to contribute to 67% of the cases of high homocysteine. <h3>Conclusions.</h3> —These results indicate a strong association between homocysteine concentration and folate, vitamin B<sub>12</sub>, and vitamin B<sub>6</sub>status, as well as age. It is possible that a substantial majority of the cases of high homocysteine in this older population can be attributed to vitamin status. (<i>JAMA</i>. 1993;270:2693-2698)
A phase I study evaluating COM701 in patients with advanced solid tumors.
Authors: Drew W. Rasco, Kyriakos P. Papadopoulos, Adeboye H. Adewoye, John Hunter, Denise Ramsey, Adam ElNaggar, Amita Patnaik, Daniel A. Vaena
Journal: Journal of Clinical Oncology (2019)

TPS40 Background: Novel checkpoint therapies are needed for the treatment of patients who relapse/refractory to treatment with checkpoint inhibitors. COM701 is a novel first-in-class humanized IgG4 monoclonal antibody that binds with high affinity to poliovirus receptor related immunoglobulin domain containing (PVRIG) blocking its interaction with it's ligand, PVRL2. We have demonstrated in preclinical experiments that inhibition of PVRIG leads to activation of T cells in the tumor microenvironment generating an anti-tumor immune response leading to tumor growth inhibition. We hypothesize that COM701 will be safe and tolerable and demonstrate antitumor activity in pts with R/R solid tumors. Methods: NCT03667716 is an ongoing open-label first-in-human phase 1 study in pts with R/R solid tumors. The initial part of this study will evaluate the safety and tolerability of escalating doses of COM701 monotherapy IV Q3 weekly. Key Inclusion Criteria: Age ≥18 yrs, histologically or cytologically confirmed, locally advanced or metastatic solid malignancy and has exhausted all the available standard therapy or is not a candidate for the available standard therapy, ECOG performance status 0-1, prior anti-PD-1, anti-PD-L1, anti-CTLA-4, OX-40, CD137. Key Exclusion Criteria: Active autoimmune disease requiring systemic therapy in the last 2 years prior to the first dose of COM701, symptomatic interstitial lung disease or inflammatory pneumonitis, untreated or symptomatic central nervous system metastases. Primary outcome measures are the incidence of adverse events and dose-limiting toxicities (21-day DLT window), pharmacokinetics of COM701 and to identify the maximum tolerated dose and/or the recommended dose for expansion. Secondary outcome measures are to characterize the immunogenicity and preliminary antitumor activity of COM701. Study Design: Accelerated titration design consisting of single subject cohorts has been implemented for the initial cohorts. Statistical Considerations: Adverse events graded as per CTCAE v4.03, responses as per RECIST v1.1. The analyses of all study objectives will be descriptive and hypothesis generating. As of the date of this submission a third single subject dose cohort has been filled.
Abstract 144: Characterization of glioma subtype-specific macrophage-tumor interactions using single-cell RNA-seq
Authors: Rohit Rao, Ravinder Verma, Jincheng Wang, Qing Richard Lu
Journal: Cancer Research (2019)

Abstract Glioblastomas are malignant brain tumors that carry a poor prognosis. The tumor microenvironment has been identified as an important regulator of tumor growth and may represent a novel target for therapy. We have developed mouse models corresponding to two different glioma molecular subtypes, proneural and mesenchymal, to identify changes in microenvironment composition between glioma subtypes. We performed Drop-Seq on endpoint tumors from the proneural glioma model and found that tumor associated macrophages and microglia are the most prominent infiltrating microenvironmental population in proneural glioma. We profiled receptor-ligand interactions between tumor macrophages and tumor cells to identify the mechanisms by which macrophages regulate tumor growth. We identified several regulators previously published in the literature that regulate glioma growth such as pleiotrophin, Igf-1, and osteopontin, as well as some new candidate regulators prosaposin, oncostatin M and thrombospondin. Future directions include validation of tumor-microenvironment interactions using CRISPR activation in vitro, characterization of the tumor microenvironment in mesenchymal-like glioblastoma via single-cell RNA-sequencing, and changes in tumor microenvironment composition and function following treatment with chemotherapy or radiotherapy. A better understanding of tumor-microenvironment interactions in glioma will aid development of new therapies to promote tumor regression Citation Format: Rohit Rao, Ravinder Verma, Jincheng Wang, Qing Richard Lu. Characterization of glioma subtype-specific macrophage-tumor interactions using single-cell RNA-seq [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 144.
Intravenous Placentography. A Report of 62 Cases
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prophylaxis of warm-water-immersion foot
Authors: L. J. Buckels
Journal: JAMA (1967)

Warm-water-immersion foot has caused a large number of casualties among our troops fighting in Vietnam. A prophylaxis against this condition was studied. A silicone grease was applied to the feet of 52 men every 24 hours. Their feet were exposed to an occlusive, wet environment for five days. Mild or early changes of immersion foot developed in six of the men and all of the subjects completed the test. Six volunteers were exposed to the same wet conditions without using silicone grease; symptomatic immersion foot developed in five of these subjects and four were unable to continue in the test beyond the third day due to the severity of their symptoms.
Pediatrics.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archie Cochrane revisited
Authors: R. J. Bulger
Journal: JAMA (1988)

ARCHIE Cochrane,<sup>1</sup>the well-known British epidemiologist who used to quip that it was not fair to label him a socialist just because he advocated that all effective health care should be free, came to Washington, DC, 15 years ago and became the star performer in health-policy circles. His message was simple: Because so little of health care had been proved to be effective, there was plenty of room for capitalism after one distributed all the<i>effective</i>health care for free. Our national response to the challenge inherent in Dr Cochrane's quip has been the investment of very modest sums in technology assessment,<sup>2</sup>health services research, and the training of the kinds of professionals needed to carry on this very important, but admittedly very applied and highly complex, research. Who can blame us? It is, after all, much more fun and much more stimulating to continue to push back
Luvvies' guide
Authors: J. O. Drife
Journal: BMJ (1999)

<i>Damon Seerewijf is a renaissance doctor. His exhibition of abstract medical art opened recently at the Galerie La Vage in Paris, but his day job is professor of molecular umbiloscopy at the University of Palm Beach. Author of more than 200 papers and a syndicated column, he recently converted to Buddhism.</i>
DOCTOR VIS-A-VIS POET
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Natural History of Peanut Allergy and Predictors of Persistence in the First 4 Years of Life: A Population-Based Assessment
Authors: Rachel L. Peters, Katrina Jane Allen, Shyamali Dharmage, Jennifer Koplin, Thahn Dang, Adrian Lowe, Mimi L.K. Tang, Lyle Gurrin
Journal: Journal of Allergy and Clinical Immunology (2015)
PLATINUM SENSITIVITY
Authors: G. M. Levene
Journal: British Journal of Dermatology (1971)

Journal Article PLATINUM SENSITIVITY Get access G. M. Levene G. M. Levene The Institute of Dermatology Homerton Grove London, E9 6BX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue 6, 1 December 1971, Pages 590–593, https://doi.org/10.1111/j.1365-2133.1971.tb14090.x Published: 01 December 1971
Bioaerosol Lung Damage in a Worker with Repeated Exposure to Fungi in a Water-Damaged Building
Authors: Douglas Trout, Jonathan Bernstein, Kenneth Martinez, Raymond Biagini, Kenneth Wallingford
Journal: Environmental Health Perspectives (2001)

There has been increased concern over health effects related to potential exposure of building occupants to bioaerosols. We report the case of a worker with a respiratory illness related to bioaerosol exposure in a water-damaged building with extensive fungal contamination. We performed environmental tests to evaluate potential exposure to fungi, and we used mycotoxin-specific IgG antibody in serologic studies in the attempt to evaluate exposure to mycotoxins. Extensive fungal contamination was documented in many areas of the building. Penicillium, Aspergillus, and Stachybotrys species were the most predominant fungi found in air sampling. Our serologic test was not useful in differentiating workers who were probably occupationally exposed to mycotoxins from those who were not; however, it did yield evidence that individuals may make specific IgG antibodies to macrocyclic tricothecene mycotoxins. Further research is needed concerning health effects related to bioaerosol exposures, particularly regarding markers of exposure to specific fungi that may produce mycotoxins. In the absence of clinical tools specific for evaluation of mycotoxin-related illness, a systematic clinical approach for evaluating persons with suspected building-related respiratory illness is warranted.
Oxford Hospital Services Development Trust.
Journal: BMJ (1967)

Future of Public Health Service-Reid mittee could, if need be, initiate studies where there are gaps in existing knowledge.Considerable lip-service is paid to the importance of public health, but this will not be sufficient to maintain morale and to boost flagging recruitment in a branch of the profession which, on the evidence of Warren and Cooper's inquiry, is one with an age structure that can only give rise to anxiety.It might be' added that there are also grounds for believing that recruit- ment has also become unsatisfactory from the qualitative point of.view, with the constant danger that a vicious circle could be established whereby indifferent staffing led to a content and a standard of work which were not in keeping with present and future requirements.Unless there is an early and penetrating official inquiry, with wide terms of reference, and unless this is followed by vigorous action, the service will inevitably fail to attract its fair share of the ablest medical graduates.Should this state of affairs come about, the resulting damage would extend far beyond the boundaries of public health, to affect the whole pattern and quality of medical care in this country.
A NEW AND ESSENTIAL POINT IN THE BLOCKING OF THE INTERNAL LARYNGEAL NERVE
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Normal Bones and Joints, Isidore Cohn, M.D., F.A.C.S., University. With a Foreword General and Clinical Surgery, Pp. 218, with 251 illustrations. Roentgenologically CONSIDERED.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats:</i> Percentage* of Adults Aged ≥20 Years Who Ever Told A Doctor That They Had Trouble Sleeping,<sup>†</sup> by Age Group and Sex — National Health and Nutrition Examination Survey, 2013–2014
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In 2013-2014, 28.0% of U.S. adults reported that they had told a doctor or other health professional that they had trouble sleeping. A smaller percentage of adults aged 20-39 years (19.2%) reported having trouble sleeping compared with persons aged 40-59 years (32.8%) and ≥60 years (33.2%). This pattern by age group was observed for both men and women, although larger percentages of women aged 40-59 years and ≥60 years reported trouble sleeping compared with men in those age groups.
<i>Intelligence and Social Valuation. A Practical Method for the Diagnosis of Mental Deficiency and Other Forms of Social Inefficiency</i>. By Richard A. Beiuw and S. D. Porteous. (<i>Publications of The Training School at Vineland, New Jersey. Department of Research, No. 20, May, 1920</i>.)
Authors: W. R. D.
Journal: American Journal of Psychiatry (1921)
A nationwide multicenter study of Japanese patients with unresectable hepatocellular carcinoma treated with regorafenib in real-world practice
Authors: Kaoru Tsuchiya, Masayuki Kurosaki, Azusa Sakamoto, Hiroyuki Matusawa, Chitomi Hasebe, Takehiko Abe, Kouji Joko, Chikara Ogawa, Koichiro Furuta, Atsunori Kusakabe, Haruhiko Kobashi, Hiroyuki Kimura, Tomomichi Matsushita, Yasushi Uchida, Namiki Izumi
Journal: Journal of Hepatology (2020)
ERRATA
Authors: Daniel Haller, Angela Chetrit, Galit Hirsh-Yechezkel, Yehuda Ben-David, Flora Lubin
Journal: Journal of Clinical Oncology (2007)

contained errors.In Table 2, under DLT, the toxicity for GGT was given as Grade 4, whereas it should have been Grade 3. Also, the toxicity for neutropenia was given as Grade 3, whereas it should have been Grade 4. Corrected Table 2 is reprinted below in its entirety.In the Results section, under Toxicity, the fourth sentence was given as: "Two of four patients treated at 2,480 mg/m 2 experienced DLT, with grade 3 neutropenia and rash occurring in one patient, and grade 3 neutropenia, rash, diarrhea, and rectal hemorrhage with grade 4 thrombocytopenia, elevated lipase, gamma-glutamyltransferase, hypophosphatemia, hypokalemia, and hyponatremia occurring in a second patient." While it should have read: "Two of four patients treated at 2,480 mg/m 2 experienced DLT, with grade 4 neutropenia and grade 3 rash occurring in one patient, and grade 3 rash, diarrhea, rectal hemorrhage and gamma-glutamyltransferase with grade 4 neutropenia, thrombocytopenia, elevated lipase, hypophosphatemia, hypokalemia, and hyponatremia occurring in a second patient."
Centennial Symposium on Science and Research
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Centennial Symposium on Science and Research Get access JNCI: Journal of the National Cancer Institute, Volume 52, Issue 5, May 1974, Page 1679, https://doi.org/10.1093/jnci/52.5.1679-a Published: 01 May 1974
Viral hepatitis type B presenting with seizure
Authors: B. R. Brooks
Journal: JAMA (1977)

NEUROLOGICAL signs and symptoms may rarely herald the onset of infectious hepatitis.<sup>1,2</sup>Seizures as a presenting sign are exceedingly rare. Four cases of convulsions preceding or coincident with the onset of the icteric phase of infectious hepatitis have been documented,<sup>3,4</sup>and one case of status epilepticus has recently been reported.<sup>4</sup>None of these cases were shown to be associated with hepatitis type B surface antigen(HB<sub>s</sub>Ag)-positive viral hepatitis. A patient with viral hepatitis type B was recently admitted to this hospital after a generalized tonic-clonic seizure. Focal EEG changes remitted during the convalescent stage of his illness, and the patient has remained free of clinical or EEG evidence of seizures during a four-year period of observation. <h3>Report of a Case</h3> A 21-year-old, right-handed male construction worker was admitted to the Massachusetts General Hospital after a tonic-clonic convulsion lasting approximately two minutes unassociated with tongue-biting or incontinence.
Critical care computing
Authors: J. J. Cottrell
Journal: JAMA (1982)

We have successfully implemented a microcomputer system in our intensive care unit to perform many routine calculations. A software package offers a variety of programs, including hemodynamic calculations, blood gas analysis, and calculation of infusion rates of potent intravenous drugs. All programs are written in a highly interactive fashion, similar to that of an automatic bank teller machine, so that no training is necessary. Low initial cost, reliability, and a reduction in medication errors make this an attractive addition to the intensive care environment. (<i>JAMA</i>1982;248:2289-2291)