tbuckley/cabot-search huggingface dataset:
The UK experience of liver transplantation in patients receiving opiate replacement therapy
Authors: B. J. Hogan, E. Shepherd, I. Webzell, K. Webb, K. Agarwal, M. Aldersley, A. Bathgate, J. Ferguson, W. J. H. Griffiths, M. Hope, J. Wood, S. Masson, K. Rothwell, D. Thorburn
Journal: Gut (2011)

<h3>Introduction</h3> There is limited outcome data on patients undergoing liver transplantation (LT) while receiving opiate replacement therapy (ORT). In 2008 the UK transplant centres adopted consensus guidelines for the assessment and management of patients on ORT prior to LT. We report the collated UK experience of LT in patients receiving ORT. <h3>Methods</h3> All UK transplant centres submitted retrospective data, using a standardised proforma. <h3>Results</h3> 75 LT assessments were undertaken between 2001 and 2010 in patients using ORT, 36 pre and 39 post introduction of national guidelines. 51/75 (68%) were listed. Detailed information on aetiology was available for 44 patients listed. 38/44 (86%) were male, median age was 47 (32-61). Aetiology of liver disease was Hepatitis C virus (HCV) in 27/44 (61%), HCV and alcohol in 14/44 (32%) and alcohol in 3/44 (7%). 13/44 patients had hepatocellular carcinoma. Pre-2008 14/28 (50%) underwent formal substance misuse assessment prior to listing, compared to 13/14 (93%) post-2008. 42/44 patients injected (39/42 heroin) and 2/44 inhaled/smoked illicit drugs for a median duration of 15 years. The median abstinence from illicit drug use and duration of ORT were both 60 months. ORT was methadone in 40/44, buprenorphine 2/44, dihydrocodeine 1/44 and methadone combined with diamorphine (1/44). The median dose of methadone was 40 mg at assessment and 50mg after LT. 29/51 (57%) listed received LT, 12/51 (24%) died or deteriorated, 5/44 (11%) were delisted for substance misuse, 1/51 improved and was removed from the list and 4/51 remain active. Median ITU and total hospital stay was 2 and 16.5 days respectively. Overall survival after LT was 86% at 1 year, 76% at 3 years and 62% at 5 years. Details of subsequent substance misuse post LT were available for 18/29 patients: 9/18 (50%) reported illicit drug use. Return to illicit drug use after LT was not associated with reduced survival (66% vs 78%; p&gt;0.05). <h3>Conclusion</h3> To date only a minority of patients assessed in the UK on ORT have undergone LT (29/75), however outcomes are acceptable given the indications. The introduction of guidelines has improved the rates of formal drug misuse assessment and while return to substance misuse is common, this does not adversely affect survival.
Ophthalmic Photography
Authors: Arnall Patz
Journal: JAMA (1982)

Mr Justice has assembled a diversified group of authorities in the field of ophthalmic photography, television as applied to ophthalmology, and cinematography. Each of the contributing authors has written a chapter on a technique of which he is a pioneer developer or an authority on its use. The advent of fluorescein angiography and the extension of fluorescein studies to the anterior segment of the eye represent a significant part of the text, reflecting the improvements in this methodology and its vital role in ophthalmic diagnosis and treatment. The new techniques that are presented will be especially useful to the experienced ophthalmic photographer, and the chapters on the fundamental aspects of ophthalmic photography will be valuable to the ophthalmic photographer in training and to the ophthalmologist wishing to develop ophthalmic photographic skills. Justice's own chapters represent important contributions to the text, and his editorial overview is apparent throughout the book. I
Minerva Ortopedica, Turin
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of a general anesthetic. Enflurane (Ethrane)
Journal: JAMA (1973)

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Practical Intestinal Surgery.
Journal: JAMA (1891)

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WHAT SHALL WE CLASS AS ETHICAL PREPARATIONS?
Journal: JAMA (1900)

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TRAVEL NOTES FROM SOUTH AMERICA.
Authors: NICHOLAS SENN
Journal: JAMA (1907)

<h3>V. *MEDICAL AFFAIRS IN ARGENTINA.</h3> The medical profession is well represented in Argentina. It is made up of men who stand high in the community, and who, besides attending with zeal to their legitimate work, take an active part in social and political affairs. Buenos Aires, the capital of the republic, has no lack of medical talent. With a population of about 1,000,000, it has no less than 1,500 practitioners of medicine, among them 40 from England, 2 from Switzerland and 6 or 7 from Germany, but only 1 from the United States. Dr. Palmer K. Lyon, of New York, medical director of the New York Life Insurance Company for South America, who does not practice. As in Brazil, the social status of physicians in Argentina is high, and many young men study medicine without any intention of entering practice, simply for the purpose of preparing an easy way to
Modeling of Dose-Response Relationships
Authors: Bernard Altshuler
Journal: Environmental Health Perspectives (1981)

The main dose-response models for chronic toxicity are considered. For dichotomous response, the log probit, multi-hit, and multistage models are presented. For time-to-occurrence response, the log-normal and three variations of multistage models are presented. Finally, the Cornfield hockey-stick model is considered, and, for low-dose extrapolation, it is suggested that response be taken to be proportional to dose and to a power of time determined by background response.
Council on Drugs. List No. 71. New names
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOCIETY PROCEEDINGS.
Authors: None L. H. M.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Syphilis
Authors: G. Marshall Crawford
Journal: New England Journal of Medicine (1948)

AT THE time of this writing it is approximately four years since the publication of the first report on the use of penicillin in the treatment of syphilis.1 The remarkable efficacy of this drug in combating man's most crippling venereal disease is attested by the fact that in so short a time it has become accepted as standard therapy for syphilis. A vast effort has been expended in widespread and well organized research projects, both experimental and clinical. From ten to twenty years are required to evaluate properly the therapeutic results of any approach to syphilis in all respects except . . .
Abstract 19177: Loss of Coronary Perfusion Efficiency in Microvascular Disease
Authors: Matthew Lumley, Matthew Ryan, Kaleab Asrress, Rupert Williams, Satpal Ari, Howard Ellis, Natalia Briceno, Simon Redwood, Brian Clapp, Michael Marber, Divaka Perera
Journal: Circulation (2015)

Introduction: Coronary Microvascular Disease (MVD) is associated with an unfavorable prognosis, even in the absence of significant epicardial disease. The pathophysiological basis of increased cardiac events is unclear. The aim of this study was to characterize the forces that govern myocardial perfusion at rest and during stress. Methods: Patients with chest pain syndromes requiring Fractional Flow Reserve (FFR) assessment were screened and those with a FFR&gt;0.80 were included. MVD was defined by coronary flow reserve (CFR) &lt; 2.0. Controls were those with CFR&gt;2.0. Simultaneous intracoronary pressure (P d ) and flow velocity (U) recordings were made at rest and hyperemia. Microvascular Resistance (MR)= P d /U. Wave intensity = dP d /dt x dU/dt and wave separation analysis was used to identify the waves that accelerate and decelerate flow. The proportional contribution of accelerating waves was assessed as an index of coronary perfusion efficiency. Results: 39 consecutive patients were enrolled, 21 had MVD and 18 comprised controls. The groups were matched for atherosclerotic risk factors, rate-pressure-product and P d . Coronary flow velocity in MVD patients was higher at rest (21.5±6.4 vs. 14.1±4.5cms -1 , p &lt; 0.001) but lower during hyperemia (28.3±13.0 vs. 45.1±13.1cms -1 , p &lt; 0.001) compared to controls. While resting MR was lower in MVD (501±162 vs. 755±262 mmHg.cm -1 .s, p = 0.001), hyperemic MR was significantly lower in controls. At rest the magnitude of the accelerating waves was higher in the MVD group than controls. The percentage contribution of accelerating waves increased with hyperemia in controls but decreased in MVD patients (figure). Conclusion: MVD manifests as resting microvascular dilation as well as diminished response to stress. While the normal heart has improved efficiency during hyperemia, in MVD efficiency decreases and as a result, flow augmentation is attenuated. These processes render the myocardium more susceptible to ischemia.
Activation of C-C β-chemokines in human peripheral blood γδ T cells by isopentenyl pyrophosphate and regulation by cytokines
Authors: Barbara Cipriani, Giovanna Borsellino, Fabrizio Poccia, Roberta Placido, Daniela Tramonti, Simona Bach, Luca Battistini, Celia F. Brosnan
Journal: Blood (2000)
Adjuvant androgen deprivation (ADT) versus mitoxantrone plus prednisone (MP) plus ADT in high-risk prostate cancer (PCa) patients following radical prostatectomy: A phase III intergroup trial (SWOG S9921) NCT00004124.
Authors: L. Michael Glode, Catherine M. Tangen, Maha Hussain, Gregory P. Swanson, David Peter Wood, Wael Sakr, Nancy Ann Dawson, Naomi B. Haas, Thomas W. Flaig, Tanya B. Dorff, Daniel W. Lin, E. David Crawford, David I. Quinn, Nicholas J. Vogelzang, Ian Murchie Thompson
Journal: Journal of Clinical Oncology (2017)
CONSTITUTIONAL HEADACHES.
Authors: GEORGE L. WALTON
Journal: JAMA (1906)

It is in the cases of old chronic suppuration, however, that we are most likely to have the more enduring forms of headache.These cases may run their course for years, without any particular symptoms.There may be so lit- tle discharge that it is regarded as wax, and the dimin- ished hearing has ceased to annoy the patient, he is so accustomed to it.Exfoliated epithelium and other products of long- continued suppuration collect in the cavities of the mid- dle ear and mastoid, often forming masses as large as. a peach stone.Examination shows that these masses are built up layer by layer, one outside another, until they assume such proportions that they not only fill the unoc- cupied space inside the temporal bone, but by pressure necrosis actually cause absorption of extensive areas of the bone.
pregnant buddha
Authors: D.A. Frater
Journal: Annals of Internal Medicine (2016)

Ad Libitum3 May 2016pregnant buddhaD.A. Frater, MDD.A. Frater, MDFrom Dallas, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-2741 Audio Reading - “pregnant buddha” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "pregnant buddha," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I look like a pregnant buddha you said and youdid walking slow step by step beret cocked slightlyfine ash cane finding solid ground you moved alonebrightest skies surrounding you enveloping you moreand more pressure upon you as you descended beforeour eyes making your way only one stop from yourhome to the park its fountain still flowing andthough consumed as you were by worse news and unwelcomefindings your eyes smiled as if the truthto the edge of smooth water that ... Author, Article, and Disclosure InformationAffiliations: From Dallas, Texas.Current Author Address: D.A. Frater, MD; e-mail, [email protected]md PreviousarticleNextarticle Advertisement Audio Reading - “pregnant buddha” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "pregnant buddha," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 3 May 2016Volume 164, Issue 9Page: 621KeywordsMortalityPregnancyWalking ePublished: 3 May 2016 Issue Published: 3 May 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Jehovah's Witnesses. The surgical/ethical challenge
Authors: J. L. Dixon
Journal: JAMA (1981)

Physicians face a special challenge in treating Jehovah's Witnesses. Members of this faith have deep religious convictions against accepting homologous or autologous whole blood, packed RBCs, WBCs, or platelets. Many will allow the use of (non-blood-prime) heart-lung, dialysis, or similar equipment if the extracorporeal circulation is uninterrupted. Medical personnel need not be concerned about liability, for Witnesses will take adequate legal steps to relieve liability as to their informed refusal of blood. They accept nonblood replacement fluids. Using these and other meticulous techniques, physicians are performing major surgery of all types on adult and minor Witness patients. A standard of practice for such patients has thus developed that accords with the tenet of treating the "whole person." (<i>JAMA</i>1981;246:2471-2472)
CRAVAT 4: Cancer-Related Analysis of Variants Toolkit
Authors: David L. Masica, Christopher Douville, Collin Tokheim, Rohit Bhattacharya, RyangGuk Kim, Kyle Moad, Michael C. Ryan, Rachel Karchin
Journal: Cancer Research (2017)

Cancer sequencing studies are increasingly comprehensive and well powered, returning long lists of somatic mutations that can be difficult to sort and interpret. Diligent analysis and quality control can require multiple computational tools of distinct utility and producing disparate output, creating additional challenges for the investigator. The Cancer-Related Analysis of Variants Toolkit (CRAVAT) is an evolving suite of informatics tools for mutation interpretation that includes mutation mapping and quality control, impact prediction and extensive annotation, gene- and mutation-level interpretation, including joint prioritization of all nonsilent mutation consequence types, and structural and mechanistic visualization. Results from CRAVAT submissions are explored in an interactive, user-friendly web environment with dynamic filtering and sorting designed to highlight the most informative mutations, even in the context of very large studies. CRAVAT can be run on a public web portal, in the cloud, or downloaded for local use, and is easily integrated with other methods for cancer omics analysis. Cancer Res; 77(21); e35-38. ©2017 AACR.
CRANIOPHARYNGIOMA
Authors: T. Hankinson, E. Fields, M. Handler, N. Foreman, A. Liu, H. L. Muller, U. Gebhardt, M. Warmuth-Metz, R.-D. Kortmann, A. Faldum, T. Pietsch, N. Sorensen, G. Calaminus, H. L. Muller, U. Gebhardt, J. Maroske, E. Hanisch, H. L. Muller, U. Gebhardt, F. Pohl, R.-D. Kortmann, A. Faldum, M. Warmuth-Metz, T. Pietsch, G. Calaminus, N. Sorensen, H. L. Muller, P. J. Enriori, U. Gebhardt, A. Hinney, J. Hebebrandt, T. Reinehr, M. Cowley, C. Roth, A. Rosenfeld, D. Arrington, M. Etzl, J. Miller, A. Gieseking, I. Dvorchik, A. Kaplan, R. Jakacki, J. Yeung, A. Panigrahy, I. Pollack, C. Mallucci, B. Pizer, M. Didi, J. Blair, S. Upadrasta, A. Doss, S. Avula, B. Pettorini, C. Alapetite, S. Puget, A. Ruffier, J.-L. Habrand, S. Bolle, G. Noel, C. Nauraye, L. De Marzy, N. Boddaert, H. Brisse, C. Sainte-Rose, M. Zerah, S. Boetto, C. Laffond, M. Chevignard, J. Grill, F. Doz, R. Jalali, T. Gupta, S. Goswami, N. Shah, N. Golambade, E. C. Ikazoboh, M. Dattani, H. Spoudeas, M. Confer, R. McNall-Knapp, S. Krishnan, N. Gross, S. Keole, D. Ormandy, R. Alston, I. Kamaly-Asl, R. Gattamaneni, J. Birch, E. Estlin, E. Kiehna, E. Laws, E. Oldfield, J. Jane
Journal: Neuro-Oncology (2012)