tbuckley/cabot-search huggingface dataset:
BRIGHTER BLOOD FOR BLUE BABIES
Authors: W. H. B.
Journal: Annals of Internal Medicine (1946)

Editorial1 February 1946BRIGHTER BLOOD FOR BLUE BABIESW. H. B.W. H. B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-2-285 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBrighter blood for blue babies! Yes, and brighter horizons for the anguished parents of these unfortunate youngsters, the majority of whom succumbed from anoxemia or cerebral thrombosis early in childhood after varying periods of chronic invalidism while the medical profession sat helplessly by with nothing to offer along therapeutic lines. Such is the significance of the daring surgical treatment of congenital malformations of the heart in which there is pulmonary stenosis or pulmonary atresia as reported by Blalock and Taussig1 within the past year.Prior to November 29, 1944 when the first operation was performed by Blalock on a 15...1 BLALOCKTAUSSIG AHB: The surgical treatment of malformations of the heart in which there is pulmonary stenosis or pulmonary atresia, Jr. Am. Med. Assoc., 1945, cxxviii, 189. CrossrefGoogle Scholar2 LUNDSGAARDVAN SLYKE CDD: Cyanosis, Medical Monographs, vol. 2, 1923, Williams and Wilkins Company, Baltimore. Google Scholar3 LEVYBLALOCK SEA: Experimental observations on the effects of connecting by suture the left main pulmonary artery to the systemic circulation, Jr. Thoracic Surg., 1939, viii, 525. CrossrefGoogle Scholar4 BLALOCK A: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1946Volume 24, Issue 2Page: 285-288KeywordsBloodHeartHypoxiaStenosisThrombosis ePublished: 1 December 2008 Issue Published: 1 February 1946 PDF downloadLoading ...
Heberden Society
Journal: Annals of the Rheumatic Diseases (1965)

This was given by Dr. James Sharp during a meeting at the Devonshire Royal Infirmary, Buxton, on June 25 and 26, 1965.He chose the theme of "Central Arthritis" and discussed the clinical and radiological features of a number of patients with ankylosing spondylitis and other types of arthritis involving predominantly the vertebrae and proximal joints.Dr. Sharp has made a particular study of this group of disorders and imparted his experience to a well-attended and appreciative meeting.Clinical Meeting.-Thefollowing papers were presented at a meeting held at the Devonshire Royal Infirmary, Buxton on June 25 and 26, 1965.arteries.In the assessment of these clinical signs, we examined the sensitivity of the carotid sinus to pressure and the 581 copyright.
Expression Diagnostic for Cancer of Unknown Primary
Journal: Cancer Research (2005)

In the article on expression diagnostic for cancer of unknown primary in the May 15, 2005 issue of Cancer Research (1), a minus sign was omitted from the equation for calculating the fold change ratio between target genes and the average expression of a panel of control genes for analysis of quantitative RT-PCR data on page 4032. The equation should have read as follows: X = 2-ΔCt; where ΔCt = Ct target - Ct average endogenous controls.
JAMA Reference Directories
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 944: Tight Binding Of Calmodulin To The Cardiac Ryanodine Receptor May Reduce The Spontaneous Ca <sup>2+</sup> Release Events Induced By Mutation-linked, Defective Inter-domain Interaction
Authors: Xiaojuan Xu, Masafumi Yano, Makoto Ohno, Hitoshi Uchinoumi, Hiroki Tateishi, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki
Journal: Circulation (2007)

Interaction between N-terminal 1– 600 and central domains 2000 –2500 of ryanodine receptor (RyR2), where many mutations have been found in patients with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVC2) or catecholaminergic polymorphic ventricular tachycardia (CPVT), was recently found to play a critical role in channel regulation. Using the domain peptide approach, here, we investigated the role of calmodulin (CaM), one of the accessory proteins of the cardiac ryanodine receptor (RyR2), on Ca 2+ release kinetics. Sarcoplasmic reticulum (SR) vesicles were isolated from dog LV muscles (n=4), then RyR2 was fluorescently labeled with methylcoumarin acetate (MCA) using DP 163–195 , which harbors a human mutation site in ARVC (R176Q), as a site-directing carrier. DP 163–195 mediated a specific MCA fluorescence labeling of central domain (60Kd) of RyR2. Addition of DP 163–195 to the MCA-labeled SR competitively induced the domain unzipping between N-terminal and central domains, as evidenced by an increased accessibility of the bound MCA to a large-size fluorescence quencher. In saponin-permeabilized cardiomyocytes, the addition of DP 163–195 markedly increased the frequency of Ca 2+ sparks (SpF; s −1 ·100μm −1 :13.1±0.9, p&lt;0.01), compared with normal cells (6.9±0.3). Addition of recombinant CaM (100nM), in the presence of KN-93 (CaMKII inhibitor), inhibited the DP 163–195 -induced increase in SpF (7.2±0.5, p&lt;0.01). This effect of CaM was, however, abolished by co-addition of the antibody against the binding site of CaM within RyR2 (3583–3603) (SpF:12.9±0.7, p=ns), strongly suggesting that the binding of CaM to RyR2 corrects the abnormal Ca 2+ release induced by DP 163–195 . The mutation made in the domain peptide, mimicking the same human mutation in ARVC (R176Q) abolished all of the effects that would have been produced by DP 163–195 . In conclusion, the mutation-linked defective inter-domain interaction between N-terminal and central domains within RyR2 (viz. domain unzipping) may increase spontaneous Ca 2+ release, perhaps by weakening CaM-binding to RyR2. Restored binding of CaM to RyR2 may correct defective channel gating of the mutant RyR2.
First Love
Authors: R B Weinberg
Journal: Annals of Internal Medicine (1997)

On Being a Doctor15 February 1997First LoveRichard B. Weinberg, MDRichard B. Weinberg, MDThe Bowman Gray School of Medicine, Winston-Salem, NC 27157Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-4-199702150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Wexler was a hospital legend even before he finished his residency, and he certainly looked the part. He sported a braided ponytail, a waxed handlebar mustache, and-decades before they adorned anyone except motorcycle outlaws and Hollywood pirates-a large gold earring. Controversy followed him everywhere. He organized the hospital clerical workers to go on strike for better benefits. He called the chief of surgery at his country club to come and see a homeless person whom the surgical residents were ignoring. It was rumored that he was having an affair with an English professor 30 years his senior. He gave the ... Author, Article, and Disclosure InformationAffiliations: The Bowman Gray School of Medicine, Winston-Salem, NC 27157Corresponding Author: Richard B. Weinberg, MD, The Bowman Gray School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntegrating Storytelling into a Communication Skills Teaching Program for Medical Oncology FellowsThe role of relationships in the professional formation of physicians: Case report and illustration of an elicitation techniqueThe process of evidence-based medicine and the search for meaning 15 February 1997Volume 126, Issue 4Page: 327-329KeywordsAntipsychoticsChartsEmotionsFearNursesOutpatient clinicsResidencySleepStormsSurgery Issue Published: 15 February 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Mumps Arthritis
Authors: R. Lass, E. Shephard
Journal: BMJ (1961)

full carafe of burgundy.Further haemorrhage may cause a break-through of the hyaloid membrane, to produce a vitreous haemorrhage.To avoid this serious complication, a slow rate of injection and limitation of the amount injected are obvious precautions.The development of a headache, due perhaps to the rise of intracranial pressure during the procedure, gives warning that the speed of injection needs slowing, but this guide is not available when a general anaesthetic is used.Further tests are necessary to determine how long the raised C.S.F.pressure lasts, but if this is not long, gentle pressure on the eyes through the closed lids at the time of the injection would raise the intraocular pressure and help to support the distended retinal vessels. SummaryTwo cases of retinal haemorrhage apparently caused by epidural injection of saline are recorded, and it is concluded that they were produced by a sudden rise in cerebrospinal pressure causing acute retinal venous congestion.
The hazard of ingested alkaline disk batteries in children
Authors: T. P. Votteler
Journal: JAMA (1983)

We have treated eight cases of childhood ingestion of alkaline disk batteries, one resulting in an esophagotracheal fistula. These batteries are capable of rapid tissue destruction on contact with moist membranes. We recommend that packaging include proper warning of this hazard and urge that retained batteries be promptly removed from the esophagus and stomach by endoscopy or laparotomy. If the battery has reached the small intestine, further transit should be monitored carefully by roentgenographic studies until recovery. Perforation is possible after eight-hour retention at a specific site. (<i>JAMA</i>1983;249:2504-2506)
Book Reviews
Authors: Giovanni A. Fava, Barrie R. Cassileth, Douglas A. Drossman, Howard Berenbaum, E.H. Friedman, Paul M.G. Emmelkamp, Patricia van Oppen, Bernhard Strauss, Manuela Burgmeier-Lohse, Gereon Heuft, Wolfgang Senf, T. Platz, B. Junkert, W. Tress, H. Schepank, F. Anagnostopoulos, Gr. Vaslamatzis, M. Markidis, Kl. Katsouyanni, St. Vassilaros, C. Stefanis, Wolfgang Wöller, Johannes Kruse, Petra Winter, Elmar J. Mans, Luciano Alberti, James D.A. Parker, Graeme J. Taylor, Michael Bagby, Douglas E. Webb, Jr., Joen Fagan, George M. Simpson
Journal: Psychotherapy and Psychosomatics (1993)
TOLERANCE TO ALCOHOL
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improvement of resting myocardial perfusion abnormalities after dipyridamole: A positron emission tomography finding associated with non obstructive coronary artery disease Stefano Sdringola, Yuko Nakagawa, Keiichi Nakagawa, Abid Assali, Mary Haynie, Nizar Mullani, Neal Parker, Mary Jane Hess, Kenneth L. Gould. University of Texas Medical School, Houston, TX
Journal: Journal of the American College of Cardiology (2001)
THE BASLE ANTI-ALCOHOL CONGRESS.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Vasculitides
Authors: David I. Abramson
Journal: JAMA (1982)

This monograph deals exclusively with various types of vasculitis, disorders arising from normal host-defense mechanisms, a response that not infrequently goes amiss. The conditions falling into such a category consist of a confusing and puzzling but still interesting group of syndromes with overlapping pathological changes. They have in common circulating immune complexes that are capable of adhering to vessel walls and reducing lumen size. The material in the 15 chapters is based on a study of patients at the National Institutes of Health over a period of 15 years, together with an extensive survey of the pertinent literature. Each entity is discussed from the standpoint of pathogenesis, immunology, pathology, clinical manifestations, and therapeutics, the approach being suitable for the needs and interests of the internist. Following three introductory chapters on classification, pathophysiology, and laboratory studies of the vasculitides, the most common group of entities, the systemic necrotizing vasculitis of the
S1 Effect of chronic CPAP therapy on upper airway muscle reflex activity
Authors: D Baldwin, J Lamont2, A Veale2, Mci Lipman, M Johnson, L Poulter, C Tasker, C Barbour, D Pitson, Rjo Davies, J Stradling, M Bofill, M Atkdns, P Strappe, D Bray, V Emery
Journal: Thorax (1995)

IL MORTIMORE and NJ DOUGLAS.(p<0.001).NM was rated significantly more comfortable compared to FM (p<0.001).Overall 19 patients said they preferred NM CPAP.The lone patient who preferred FM had significant symtoms with mouth leak using NM.We conclude tha for most patients NM is preferble to FM CPAP despite the potential advantages of FM in reducing symptoms associated with mouth air leak.Supported by the Wellcome Trust.
Non-Hodgkin's lymphoma presenting as a primary tumor of the liver: Presentation, diagnosis and outcome in eight patients
Authors: J Scoazec
Journal: Hepatology (1991)

We report the diagnostic, prognostic and therapeutic features of non-Hodgkin's lymphoma in eight patients in whom the disease was seen as a primary tumor of the liver. This series illustrates the variety of situations in which lymphoma might be diagnosed: (a) abdominal pain and hepatomegaly (three cases), (b) incidental finding at evaluation of a patient with cirrhosis (two cases), (c) secondary neoplasm after treatment for Hodgkin's disease (one case) and (d) complication of AIDS (two cases). In most cases, clinical and/or radiological features were nonspecific. However, the combination of the following features must be considered as suggestive: occurrence of an apparently primary hepatic tumor in an immunocompromised patient, absence of the usual serum tumor markers and increased serum lactic dehydrogenase activity. The final diagnosis was based on histological examination of specimens obtained by ultrasonically guided liver biopsies or at surgery. All cases belonged to unfavorable histological subtypes. Immunohistochemical findings on paraffin-embedded sections demonstrated the B-lymphocyte lineage of the seven tumors available for study. In the three patients without coexisting disease, complete remission was obtained by surgery alone or combined with chemotherapy. In the two patients with coexisting cirrhosis, outcome was rapidly unfavorable, with death occurring less than 3 mo after diagnosis. Among the three immunocompromised patients, two experienced a rapid unfavorable outcome, and the remaining one was in complete remission after surgery and chemotherapy. In conclusion, primary non-Hodgkin's lymphoma of the liver arising in patients without coexisting disease has a slow progression and might be successfully treated by surgery. In contrast, lymphomas occurring in patients with a coexisting disease, and especially, as a complication of AIDS, have a much poorer prognosis and a low response to therapy. (HEPATOLOGY 1991;13:870–875.)
Effects of Withdrawal of Tranquilizers
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The cost-quality relationship. Do we always get what we pay for?
Authors: E. H. Wagner
Journal: JAMA (1994)

The relationship between cost and quality is more than an academic concern. Assumptions about the strength and direction of the association are at the heart of the current debate about the future direction of American health care. If we assume that quality and costs are positively related, then it follows that efforts to contain costs threaten quality.<sup>1</sup>If we assume a less linear or even negative relationship, then cost containment and quality improvement may even be complementary.<sup>2</sup> See also p 1903. Donabedian et al<sup>3</sup>suggest that the use of health services beyond those needed for maximum health benefit might actually have a negative effect because of complications of the unnecessary tests and treatments. Empirical studies of the cost-quality relationship have been largely confined to hospital care and show no consistency in the direction of the associations.<sup>4</sup>The article by Starfield et al<sup>5</sup>in this issue
Apple News
Authors: Masatoshi Kudo, Masatoshi Kudo, Byung Ihn Choi, Hyun Jeong Park, Eun Sun Lee, Sung Bin Park, Jong Beum Lee, Helen M. Parsons, Quyen Chu, Jordan J. Karlitz, Jennifer L. Stevens, Linda C. Harlan, Tatsuya Yamashita, Takeshi Terashima, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko, Takashi Kumada, Masatoshi Kudo, Masashi Hirooka, Kunihiko Tsuji, Ei Itobayashi, Kazuya Kariyama, Toru Ishikawa, Kazuto Tajiri, Toshifumi Tada, Hidenori Toyoda, Kazuhiro Nouso, Hideki Kawasaki, Yoichi Hiasa, Kojiro Michitaka, Atsushi Hiraoka, Hironori Ochi, Kouji Joko, Tadaaki Arizumi, Kazuomi Ueshima, Mina Iwanishi, Tomohiro Minami, Hirokazu Chishina, Masashi Kono, Masahiro Takita, Norihisa Yada, Satoru Hagiwara, Yasunori Minami, Hiroshi Ida, Yoriaki Komeda, Mamoru Takenaka, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Masatoshi Kudo, Mengensatzproduktion, Druckerei Stückle, Druckerei Stückle, on behalf of the Real-Life Practice Experts for HCC (RELPEC) Study Group and HCC 48 Group (hepatocellular carcinoma experts from 48 clinics)
Journal: Liver Cancer (2017)
Pegylated Liposomal Doxorubicin (PLD), Vincristine and Reduced-Dose Dexamethasone (DVd) in the Treatment of Predominantly African American Population with Multiple Myeloma.
Authors: Anshul Bamrolia, Ahmad Jajeh, R. Catchatourian, David Osafo, Deimante Tamkus, Neelesh Sharma, Ghassan Zalzaleh, Sunita Nathan, Perry Menini
Journal: Blood (2006)
Primary pericardial tumor masquerading as constrictive pericarditis
Authors: V. F. Miscia
Journal: JAMA (1974)

WE REPORT an unusual clinical course and pathologic findings in a patient with primary pericardial tumor that masqueraded as constrictive pericarditis. Of approximately 44 case reports of primary pericardial tumors reviewed, only seven were diagnosed before death. The diagnosis in this patient was established antemortem by thoracotomy after cardiac catheterization disclosed findings of pericardial constriction. <h3>Report of a Case</h3> A 41-year-old man sought medical advice when he noted increasing abdominal distention, gastrointestinal upset, and constipation. He denied shortness of breath, dyspnea on exertion, cough, chest pain, night sweats, or fever. Because of a nonpulsatile epigastric mass, hepatomegaly, and ascites on physical examination, an exploratory laparotomy was performed, during which hypotension and cyanosis developed. Because of a lack of transmitted cardiac pulsations and a downward distention of the diaphragm, a transdiaphragmatic pericardiocentesis was performed and yielded 1,800 ml of sanguineous fluid with reactive mesothelial cells, but no tumor cells. The blood