tbuckley/cabot-search huggingface dataset:
Survival outcomes for various treatment modalities in advanced-stage grade 3 follicular lymphoma (FL3): A National Cancer Database (NCDB) study.
Authors: Upama Giri, Eric Vick, Sophia SeoHyeon Lee, Alaa Altahan, Noam Avraham VanderWalde, Paxton Vandiver Dickson, Jeremiah Lee Deneve, Michael Gary Martin
Journal: Journal of Clinical Oncology (2017)

7554 Background: The prognosis, response to therapy and curability of FL3 is controversial. 5-year Overall Survival (OS) in the literature ranges from 35-72% (Ganti 2006). The aim of this study was to compare the OS for patients with advanced-stage FL3 managed with various treatment modalities. Methods: We identified patients (pts) diagnosed with stage III &amp; IV FL3 between 2004 – 2012 from the NCDB and categorized them into 3 groups based on therapy – pts given single agent chemotherapy with or without radiotherapy were combined due to small sample sizes (SA±RT), multi agent chemotherapy without radiotherapy (MA-RT), and multi agent chemotherapy with radiotherapy (MA+RT). We calculated OS using Kaplan-Meier method and compared the results using Log Rank test. Cox regression model was used to identify other factors which had significant impact on OS. Results: 2,808 pts were identified – 1,508 (54%) with stage III and 1,300 (46%) with stage IV disease. Median age was 60 yrs (range 21-90yrs); 1,331 (47%) males, 1,477 (53%) females; 2,559 (91%) whites, 142 (5%) blacks. 170 cases (6%) were treated with SA±RT, 2,508 (89%) with MA-RT and 130 (5%) with MA+RT. There was no significant difference in 5-year OS between MA-RT (83%) and MA+RT (82%; HR 1.07, P=0.76). There was no difference between SA±RT (73%) and MA+RT (82%; HR 0.62, P=0.069) likely due to small sample sizes, but survival for MA-RT (83%) was significantly higher than SA±RT (73%; HR 1.78, p&lt;0.001). Cox regression indicated that age (HR 1.04, P&lt;0.001), sex (HR 0.77 for females, P=0.008), comorbidities (HR 1.48 for Charlson Deyo Score 1, P=0.001; HR 2.59 for Score 2, P&lt;0.001), stage (HR 1.29, P=0.007), insurance status (HR 0.65 for insured, P=0.048) and increasing year of diagnosis (HR 0.91, P&lt;0.001) also had significant impact on OS. Use of MA chemotherapy declined (2004 96% v 2012 91%, P=0.008) but there was no significant trend in use of radiotherapy (2004 5% v 2012 3%) during the periods studied. Conclusions: MA chemotherapy in pts with advanced-stage FL3 was associated with improved survival compared to SA therapy, and radiation does not appear to influence outcomes. Outcomes were superior to what has been previously reported.
Psychosomatic Gynecology: Including Problems of Obstetrical Care
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Trial Description, Reference Numbering, and Case Description
Journal: JAMA (2015)

Athanase Benetos, MD, PhD; Patrick Rossignol, MD, PhD; Antonio Cherubini, MD, PhD; Laure Joly, MD, PhD; Tomasz Grodzicki, MD, PhD; Chakravarthi Rajkumar, MD, PhD; Timo E. Strandberg, MD, PhD; Mirko Petrovic, MD, PhD
Rats and How to Destroy Them. Dealing with Rats in a House, Shop, Warehouse, Outbuilding, Yard, Stable, Cow-House, Fowl-house, Pig-sty, Garden, Greenhouse, or Vinery; by a River, Stream or Ornamental Water; on a Ship, Shooting Estate, or Farm; and in Sewers.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conference of Royal Colleges and Faculties in Scotland
Authors: R Porter, R Whittam, R Blowers, S Cohen, E Horton, Helen Muir, D Blow, J Mitchell, P Randle, A Dornhorst, A Goldberg, A Lever, J Walton, D Baird, J Batchelor, S Grant, R Hoffenberg, J Nunn, B Newton, W Peters, J Webb, J Cairns, M Epstein, J Gurdon
Journal: BMJ (1973)
Guildford Cathedral
Authors: J. B. G. Smith
Journal: BMJ (1958)

<h3>Abstract</h3> The count table, a numeric matrix of genes × cells, is the basic input data structure in the analysis of single-cell RNA-seq data. A common preprocessing step is to adjust the counts for variable sampling efficiency and to transform them so that the variance is similar across the dynamic range. These steps are intended to make subsequent application of generic statistical methods more palatable. Here, we describe four transformation approaches based on the delta method, model residuals, inferred latent expression state, and factor analysis. We compare their strengths and weaknesses and find that the latter three have appealing theoretical properties. However, in benchmarks using simulated and real-world data, it turns out that a rather simple approach, namely, the logarithm with a pseudo-count followed by principal component analysis, performs as well or better than the more sophisticated alternatives. <h3>Software</h3> The R package <i>transformGamPoi</i> implementing the delta method- and residuals-based variance-stabilizing transformations is available via Bioconductor. We provide an interactive website to explore the benchmark results at shiny-portal.embl.de/shinyapps/app/08_single-cell_transformation_benchmark. <h3>Contact</h3> constantin.ahlmann@embl.de
Ankylosis of the temporomandibular joint following burn
Authors: E. E. Schwartz
Journal: JAMA (1976)

DEEP, as well as subcutaneous, tissues in the vicinity of burns are subjected to severe damage. Soft-tissue fibrosis is a common problem and may be followed by calcification and ossification.<sup>1,2</sup>Bone or joint involvement, however, is rare. The following case of joint destruction in a child after a severe burn is unusual in that it involved the temporomandibular joint. <h3>Report of a Case</h3> A 10-year-old black girl was first hospitalized for second- and third-degree burns over 40% of her body surface on Dec 31, 1968, one day before her fifth birthday. The afflicted areas included the right side of her face, buttocks, and legs. Treatment consisted of fluid, blood, antibiotics, debridement, nitrofurazone dressings and skin-grafting. Dislocation of her right hip was discovered and reduced by manipulation and tenotomy of the abductor muscles in March 1969. Eight months after the burn, scars were observed on her face, back, chest, and
Liejacking
Authors: Marc D. Feldman
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Individuals with factitious disorders feign or intentionally self-induce illness because of a psychological need to assume the sick role.<sup>1</sup>These individuals often display dramatic medical conditions, such as gross bleeding or incapacitating pain, that will force doctors and others to attend to them immediately.<sup>2</sup>We describe a teenager whose factitious seizure while on an airliner not only mobilized immediate attention, but actually led to the plane's being diverted, a phenomenon we dub "liejacking." <h3>Report of a Case.</h3> —A 14-year-old boy had a 1-year history of ostensive asthma leading to continual testing and medication adjustment, but with little success. Emergency department visits had been extremely frequent, and he had received more than 100 epinephrine injections because of acute respiratory distress. On occasion, he also displayed seizures, and his medical conditions had led to his being placed in a home-schooling program. While flying from his home to
Errata
Journal: BMJ (1902)

DE. R. EDDOWES LEGAT (Cromer) writes: On the morning of May i8th I was called to a patient who had suddenly been taken ill shortly after breakfast.Whcn I saw him fifteen minutes later he was reclining in a chair, was very pale and somewhat cyanosed, and the surface of the body bathed in a cold sweat.He complained of faintness, a feeling of oppression in the chest, some disturbance of sight, and of intense itching of the skin of the hands and forearms.He volunteered the tnformation that he was suffering from blood poisoning from eating mushrooms, and that he had been affected in a similar manner last time he partook of them some ten years ago.I gave him at once an emetic (Vin.ipec.3j) which quickly had the desired result, and followed this by a dose of castor oil and a mixture containing sodium bicarbonate, spiritus ammon.co. and liquor bisimiuthi to be taken every four hours.The rash was of the nature of an erythemiia urticaria accomaanied by intense itching.It did not affect all the body simultaneously, Cut began in the hands, spreading from there up the arms, down the
Surgical Management
Authors: Robert J. Baker
Journal: JAMA (1992)

This is the second edition of this major textbook from Great Britain, edited by one author from Dublin, another from Edinburgh, and a third from London. It is clear that the first edition was successful, since the second edition has been undertaken in an upgraded form but with similar organization of information. According to the preface,<i>Surgical Management</i>is written for the "general surgical trainee." This, in its broadest sense, includes surgical residents, medical students, and any physician requiring a textbook that describes, discusses, and puts into perspective surgical diseases encountered in both surgical and nonsurgical clinical practices. The authors aver that their main focus is on gastrointestinal disease and oncology, and there is a tangible attempt, largely successful, to meet that objective. They further state that their textbook is "easy to read, well referenced and absolutely up-to-date." Indeed, it is eminently readable, contains ample numbers of references, and is
Activation of Cellular Oncogenes by Chemical Carcinogens in Syrian Hamster Embryo Fibroblasts
Authors: Rolf Ebert, J. Carl Barrett, Roger W. Wiseman, Reinhard Pechan, Eva Reiss, Gunther Rollich, Dietmar Schiffmann
Journal: Environmental Health Perspectives (1990)

Carcinogen-induced point mutations resulting in activation of ras oncogenes have been demonstrated in various experimental systems such as skin carcinogenesis, mammary, and liver carcinogenesis. In many cases, the data support the conclusion that these point mutations are critical changes in the initiation of these tumors. The Syrian hamster embryo (SHE) cell transformation model system has been widely used to study the multistep process of chemically induced neoplastic transformation. Recent data suggest that activation of the Ha-ras gene via point mutation is one of the crucial events in the transformation of these cells. We have now cloned the c-Ha-ras proto-oncogene from SHE cDNA-libraries, and we have performed polymerase chain reaction and direct sequencing to analyze tumor cell lines induced by different chemical carcinogens for the presence of point mutations. No changes were detectable at codons 12, 13, 59, 61, and 117 or adjacent regions in tumor cell lines induced by diethylstilbestrol, asbestos, benzo(a)pyrene, trenbolone, or aflatoxin B1. Thus, it is not known whether point mutations in the Ha-ras proto-oncogene are essential for the acquisition of the neoplastic phenotype of SHE cells. Activation of other oncogenes or inactivation of tumor suppressor genes may be responsible for the neoplastic progression of these cells. However, in SHE cells neoplastically transformed by diethylstilbestrol or trenbolone, a significant elevation of the c-Ha-ras expression was observed. Enhanced expression of c-myc was detected in SHE cells transformed by benzo(a)pyrene or trenbolone.
Incorrect Author Surname, Affiliation, and Figure Key
Journal: JAMA Internal Medicine (2019)

Nicolás Martínez-Velilla, PhD, MD; Alvaro Casas-Herrero, PhD, MD; Fabricio Zambom-Ferraresi, PhD; Mikel L. Sáez de Asteasu, MSc; Alejandro Lucia, PhD, MD; Arkaitz Galbete, PhD; Agurne García-Baztán, MD; Javier Alonso-Renedo, MD; Belen González-Glaría, PhD, MD; María Gonzalo-Lázaro, MD; Itziar Apezteguía Iráizoz, PhD, MD; Marta Gutiérrez-Valencia, PharmD; Leocadio Rodríguez-Mañas, PhD, MD; Mikel Izquierdo, PhD
Activation of Dihaloalkanes by Glutathione Conjugation and Formation of DNA Adducts
Authors: F. Peter Guengerich, Lisa A. Peterson, Joan L. Cmarik, Nobuyuki Koga, Philip B. Inskeep
Journal: Environmental Health Perspectives (1987)

Ethylene dibromide (1,2-dibromoethane, EDB) can be activated to electrophilic species by either oxidative metabolism or conjugation with glutathione. Although conjugation is generally a route of detoxication, in this case it leads to genetic damage. The major DNA adduct has been identified as S-[2-(N7-guanyl)ethyl]glutathione, which is believed to arise via half-mustard and episulfonium ion intermediates. The adduct has a half-life of about 70 to 100 hr and does not appear to migrate to other DNA sites. Glutathione-dependent DNA damage by EDB was also demonstrated in human hepatocyte preparations. The possible relevance of this DNA adduct to genetic damage is discussed.
Troubles with I.U.C.D.s.
Journal: BMJ (1973)

numbers.It is difficult to imagine how pneumatic com- pression can cause harm, so that must be the preferred mechanical method.All the pharmacological techniques may cause bleeding, and much more information is needed before they come into general use.Any method which is to be used on all patients with the object of preventing four or five deaths per thousand patients will have to 'be free of side effects, cheap, and simple before it is universally accepted.At present the published evidence suggests that more value will be obtained from screening, early diagnosis, and vigorous treatment than from the uncritical use of unproved methods of prophylaxis.
JOHNS HOPKINS HOSPITAL
Authors: Amos R. Koontz
Journal: JAMA (1960)

<h3>To the Editor:—</h3> I would like to call attention to one slight historical mistake in an editorial inThe Journal, June 25, page 912. It is stated that the Johns Hopkins Hospital, in Baltimore, was founded in 1891. The Johns Hopkins Hospital was opened for patients in May, 1889. Just when it was founded, I am not sure, as the money for the founding of it was left by Johns Hopkins, who died a good many years before that. The exact details of this will be found in Alan Chesney's book, "Johns Hopkins Hospital and the Johns Hopkins University School of Medicine: A Chronicle" (Homewood, Baltimore Johns Hopkins Press: vol. 1, 1943; vol. 2, 1958).
Especialidades Ginecologia. Enfermedades de los Organos Genitales Externos, de la Vagina, de la Uretra, de los Uréteres y de la Vejiga de la Mujer.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P212 Interventions to increase referral to and uptake of pulmonary rehabilitation programmes for people with chronic obstructive pulmonary disease (COPD): a systematic review
Authors: F Early, I Wellwood, I Kuhn, T Dickerson, J Ward, J Brimicombe, C Deaton, J Fuld
Journal: Thorax (2016)

<h3>Introduction and objectives</h3> Pulmonary Rehabilitation (PR) reduces the number and duration of hospital admissions, readmissions and improves health-related quality of life, e.g. breathlessness and fatigue, in patients with COPD. Despite evidence, guidelines and quality standards, PR is significantly underutilised with under-referral (15% of normative need) and limited uptake (&lt;70% of those referred attend initial assessment) contributing to poor treatment access. We aimed to address the research question: How effective are interventions to improve referral to and uptake of exercise-based pulmonary rehabilitation programmes in patients with COPD when compared to standard care or no intervention? <h3>Methods</h3> Systematic review following recognised methods, including all published observational, interventional, qualitative and quantitative studies of interventions specifically intended to increase levels of referral and/or uptake of pulmonary rehabilitation in patients with COPD. Exclusion criteria: individual case studies, conference abstracts and opinion pieces. No date or language restrictions. Search terms included: ‘pulmonary rehabilitation’ AND ‘referral’ OR ‘uptake’ applied to MEDLINE, EMBASE, CINAHL, PsychINFO, ASSIA, BNI, Web of Science and Cochrane Library from inception to June 2016 supplemented by review of reference lists and citation search. Titles, abstracts and full papers were reviewed independently, quality appraised (using Cochrane Collaboration’s tool for RCTs and ROBINS-I, AMSTAR) and entered into summary tables. The protocol was registered (PROSPERO) and reported according to PRISMA guidelines. <h3>Results</h3> We screened 3217 references, from which 7 papers including 6345 patients and 22 clinicians met inclusion criteria. Most studies (n = 5) were UK based. Designs, interventions and scope of studies were diverse with interventions often part of multifaceted evidence based management of COPD. Examples included computer based prompts at practice nurse review, patient information, financial incentives. Most studies (n = 5) reported improvements in referral or uptake of PR (range 0% – 25% increase), however most had methodological limitations with risk of bias. Due to heterogeneity, studies were not considered combinable and meta-analysis was inappropriate. <h3>Conclusions</h3> There is limited evidence for the efficacy of interventions to increase referral and uptake of PR. Existing studies are diverse and further testing using robust methods in various populations and settings is required to optimise access to PR.
Reaction of Mineral Dusts with Primary Lung Fibroblast Cultures
Authors: R. J. Richards, J. Hunt
Journal: Environmental Health Perspectives (1983)

The complex metabolism of rabbit lung fibroblast cultures maintained over 24 days in vitro and their interaction with the fibrogenic group of asbestos minerals is reviewed. The differential effects of nine dusts given as a single dose to 3-day-old fibroblast cultures which were then analyzed for DNA, protein and cell mat hydroxyproline after 3 weeks are discussed. A comparison is made of the ability of these minerals to promote reticulin deposition in vivo following instillation into rats with the ability of each mineral to alter cell mat hydroxyproline levels in fibroblast cultures. Because this comparison is poor for some of the minerals investigated, it is concluded that with the current methodology the fibroblast cultures do not provide an adequate in vitro test system for assessing the potential fibrogenicity of a mineral in vivo.
The current status of influenza vaccines
Authors: T. C. Eickhoff
Journal: JAMA (1974)

MORE misinformation exists about influenza vaccine, among the public and in the medical profession, than about any other immunizing agent in common use. Such comments as "If I take my flu shot, I don't have a cold all year" and "Flu shots don't do me any good because I have just as many colds anyway" are heard in offices, clinics, and in casual conversation. Physicians are confused. Uncertainty about the character and frequency of reactions to vaccine, the continuous parade of apparently "new" influenza viruses, seemingly contradictory information on the effectiveness of influenza vaccine, the necessity of annual immunization, and the difficulty in diagnosing influenza all combine to give influenza vaccine an image that is something less than glowing. Fundamental to an understanding of the problem is an appreciation of the antigenic changes that continuously occur, principally among influenza A viruses, but to a lesser extent among the B viruses.