tbuckley/cabot-search huggingface dataset:
Hemodialytic Hypocapnia
Authors: GRAZIANI GIORGIO
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 May 1970Hemodialytic HypocapniaGRAZIANI GIORGIO, M.D., PONTICELLI CLAUDIO, M.D., DI FILIPPO GEMMA, M.D., REDAELLI BRUNO, M.D.GRAZIANI GIORGIO, M.D.Search for more papers by this author, PONTICELLI CLAUDIO, M.D.Search for more papers by this author, DI FILIPPO GEMMA, M.D.Search for more papers by this author, REDAELLI BRUNO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-757 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their article, "Acid-Base Status During the Interdialytic Period in Patients Maintained with Chronic Hemodialysis" (Ann Intern Med 71:1105-1111, 1969) Rosenbaum and co-workers stress the difficulty in interpreting the considerable hypocapnia always found at the end of the hemodialysis. For most authors it is due to the hyperventilation caused by persistent acidosis. In our opinion the remarkable diffusibility of CO2 across the dialyzing membrane should be considered in the interpretation of this phenomenon.We have examined the arteriovenous difference of PCO2by drawing blood at the entrance and at the exit of the dialyzer in a recent...Reference1. PAULIREUBI HF: Respiratory control in uraemic acidosis. J Appl Physiol 18:717, 1963 CrossrefMedlineGoogle Scholar1. EARNESTSADLERINGRAM DJR: Acid-base balance in chronic hemodialysis. Trans Amer Soc Artif Intern Organs 14:434-437, 1968 MedlineGoogle Scholar2. WELLERSWANMERRILL JRJ: Changes in acid-base balance of uremic patients during hemodialysis. J Clin Invest 32:729-735, 1953 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Urology Nephrology Section Milan University Milan Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 757-758KeywordsBloodPartial pressure of carbon dioxide Issue Published: 1 May 1970 PDF DownloadLoading ...
Herbal Medicine Is Potent Estrogen
Journal: Environmental Health Perspectives (1999)

ForumAccording to the EWG report, the TRI data reveal a "shocking practice by American fertilizer companies.They rou- tinely 'recycle' toxic factory waste of all kinds into fertilizers....The stuff is laden with lead, cadmium, arsenic, dioxin, and other high risk toxics that end up in fertiliz- ers widely used by farmers in the United States."The group charged that state rules on the practice amount to a "loophole-riddled regulatory 'safety net."'Although the EWG report does not say that actual harm from the practice has been demonstrated, Todd Hattenbach, an EWG researcher, says, "It's a dangerous practice because nobody is looking dosely [at it].The EPA is doing risk assessments, but they don't know what's going into the waste streams right now."The EWG contention is that, rather than having to demonstrate injury, companies should be required to demon- strate the safety of the practice before it is allowed.John Mortvedt, a retired soil scientist who studied fertilizer contamination for 20 years at the National Fertilizer and Environmental Research Center in Muscle Shoals, Alabama, says the Seattle Times report was more sensational than it needed to be.But he agrees that the story exposed the RCRA loophole, the so-called "K061" provision, which allows the unregulated transfer of dust-a waste product from the electric arc furnaces used in steel mills-to fertilizer companies.The dust contains zinc, an essential plant micronutrient, as well as lead, arsenic, cadmium, and nickel.According to the EWG report, nearly 30% of the industrial waste that became fertilizer originated at steel mills.Due to the reporting system used in the TRI, the 271 million pounds of waste that became fertilizer between 1990 and 1995 may actually make up only part of the total transfers.Nevertheless, say critics of the EWG report, the total amount of waste
Abstract 3624: Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau.
Authors: Shuguang Leng, Maria A. Picchi, Yushi Liu, Yong Lin, Christine A. Stidley, Frank D. Gilliland, Marty R. Jacobson, Steven A. Belinsky
Journal: Cancer Research (2013)

Abstract Epidemiological studies of underground miners suggest that occupational exposure to radon causes lung cancer with squamous cell carcinoma (SCC) as the predominant histological type. However, the genetic determinants for susceptibility of radon-induced SCC in miners are unclear. Double-strand breaks (DSBs) induced by radioactive radon daughters are repaired primarily by non-homologous end joining (NHEJ) that is accompanied by the dynamic changes in surrounding chromatin, including nucleosome repositioning and histone modifications. Thus, a molecular epidemiological study was conducted to assess whether genetic variation in 16 genes involved in NHEJ and related histone modification affected susceptibility for SCC in radon-exposed former miners (267 SCC cases and 383 controls) from the Colorado plateau. A global association between genetic variation in the haplotype block where SIRT1 resides and the risk for SCC in miners (P=0.003) was identified. Haplotype alleles tagged by the A allele of SIRT1 rs7097008 were associated with increased risk for SCC (Odds Ratio = 1.69, P = 8.2×10−5) and greater survival in SCC cases (Hazard Ratio = 0.79, P = 0.03) in miners. Functional validation of rs7097008 demonstrated that the A allele was associated with reduced gene expression in bronchial epithelial cells and compromised DNA repair capacity in peripheral lymphocytes. Together, these findings substantiate genetic variation in SIRT1 as a risk modifier for developing SCC in miners and suggested that SIRT1 may also play a tumor suppressor role in radon-induced cancer in miners. Citation Format: Shuguang Leng, Maria A. Picchi, Yushi Liu, Yong Lin, Christine A. Stidley, Frank D. Gilliland, Marty R. Jacobson, Steven A. Belinsky. Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3624. doi:10.1158/1538-7445.AM2013-3624
ECG Challenge: March 4, 2014
Authors: Philip Podrid
Journal: Circulation (2014)

A 48-year-old man with a history of hyperlipidemia, hypertension, diabetes mellitus, and cigarette smoking presents to his primary care physician for a routine physical examination.The results of his examination are normal, but his pulse is noted to be irregular, resulting in an ECG.What is the diagnosis?To submit your diagnosis, go to http://circ.ahajournals.org/letters/submit/circulationaha;129/9/1045.The diagnosis will follow in next week's issue (March 11).
Renal pelvic tumors
Authors: H. Grabstald
Journal: JAMA (1971)

Seventy patients with renal pelvic tumors were grouped during a clinicopathologic study according to a new proposed classification that is based on tumor stage and grade. Prognosis is excellent for patients with histologically benign papilloma (group I) or noninvasive or focally invasive papillary carcinoma (group II). It appears good also for patients with fully invasive carcinoma that is still confined to the kidney itself (group III). Invasion outside the kidney or renal pelvis (group IV) is an ominous sign. In about one half of the patients there were associated tumors of bladder or ureter, and prognosis may be determined by these other tumors. Bladder tumors that developed after pelvic tumors almost all appeared within three years. Nephrectomy and total ureterectomy remain the treatment of choice under most circumstances. Local resection or partial excision is recommended for bilateral pelvic tumors.
LETTER FROM PARIS.
Authors: None A. B.
Journal: JAMA (1888)

(FROM OUR OWN CORRESPONDENT.) Transmissibility of Tetanus—Infectious Nature of Tetanus—Osseous Grafts—Corrosive Sublimate in Cholera—Management of Abortion—Periodical Neuralgia of the Cornea. Professor Verneuil, who introduced into science the notion of the contagiousness of tetanus, and its equine origin, follows the development of this idea with great solicitude and embraces every opportunity of justifying his views on the subject. At a recent meeting of the Academy of Medicine he read a report on two papers, the one by Dr. P. Berger, entitled, " The transmissibility of tetanus from man to man," and the other by Dr. G. Richelot " on the infectious nature of tetanus." M. Verneuil reviewed the whole subject in a most masterly manner, and terminated his report with the following conclusions: 1. The intra-human transmission which although demonstrated as yet by only a small number of facts, cannot be contested in principle. 2. This transmission does not appear to be affected
Bioethics and Religion
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immune Response
Authors: Steven D. Pearson
Journal: JAMA (1986)

Much has been said about acquired immunodeficiency syndrome (AIDS). We here in San Francisco, and especially at the University of California, San Francisco, School of Medicine, take for granted the deluge of information we receive on this protean disease. But one aspect of AIDS really hasn't been talked about much—its effect on medical residents and students. The extent to which AIDS dominates the medical training at UCSF can be seen in the caseload of any medical resident at the San Francisco General Hospital—often more than 50% AIDS related. The abrupt crescendo of AIDS cases has focused tremendous pressures on the quality of medical education now that so much of the teaching and training must be oriented toward the care of a unique group of patients. And the future would seem to hold only more AIDS cases for years to come. In addition to educational demands, dealing with AIDS patients has
Metabolic and genetic liver diseases
Journal: Hepatology (1995)

The CRISPR/Cas9 system has recently been shown to facilitate high levels of precise genome editing using adeno-associated viral (AAV) vectors to serve as donor template DNA during homologous recombination (HR). However, the maximum AAV packaging capacity of ∼4.5 kb limits the donor size. Here, we overcome this constraint by showing that two co-transduced AAV vectors can serve as donors during consecutive HR events for the integration of large transgenes. Importantly, the method involves a single-step procedure applicable to primary cells with relevance to therapeutic genome editing. We use the methodology in primary human T cells and CD34+ hematopoietic stem and progenitor cells to site-specifically integrate an expression cassette that, as a single donor vector, would otherwise amount to a total of 6.5 kb. This approach now provides an efficient way to integrate large transgene cassettes into the genomes of primary human cells using HR-mediated genome editing with AAV vectors.
Surveillance Cultures of the Urine and Catheter Placement
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biomonitoring Studies and Susceptibility Markers for Acrolein Congeners and Allylic and Benzyl Compounds
Authors: Erwin Eder, Christian Hoffman, Sabine Sporer, Sabine Scheckenbach
Journal: Environmental Health Perspectives (1993)

The importance of genotoxic acrolein congeners and allylic and benzyl compounds as industrial compounds, ubiquitous environmental pollutants, and naturally occurring substances necessitates the availability of adequate biomonitoring techniques. Endogenously formed acrolein congeners are considered to play an important role in carcinogenesis. Our studies have demonstrated that acrolein congeners react with DNA components and form adducts with the guanine moiety. We have identified and characterized cyclic 1,N2-deoxyguanosine adducts, cyclic 7,8-guanine adducts, linear 7-guanine adducts, 1,N2,7,8-bis-cyclic adducts, and 1,N2-cyclic, 7-linear bis adducts. Both the reactivity of the acroleins toward nucleosides and their mutagenicity in S. typhimurium TA100 decrease with increasing degree of alkyl substitution. Adducts are now available as reference substances for developing sensitive detection methods. Of the biomonitoring methods investigated for allylic and benzyl compounds, the detection of cysteine and histidine adducts isolated from hemoglobin seems to be the most sensitive. Gas chromatography with electron capture detection of heptafluorobutyric acid derivatives allows a detection limit in the femtomole range, HPLC-fluorescence detection of O-phthalic dialdehyde derivatives allows a limit in the picomole range, and detection of 9-fluorenylmethyl-chlorofomiate derivatives allows a limit in the femtomole range.
Ocular Pathology
Authors: Jay I. Perlman
Journal: JAMA (1996)

This excellent text is the fourth edition and a revision of<i>Ocular Pathology: A Text and Atlas</i>, by the same authors. It is also complementary to<i>Ocular Pathology: A Color Atlas</i>, second edition, by Gower Medical Publishing. In fact, the authors have combined the best features of both of these books into one comprehensive ocular pathology text. They have taken advantage of advances in color photographic reproduction to expand on the already excellent photographs of the color atlas. At the same time, they have maintained and expanded on the comprehensive textual information provided in the prior edition of the textbook. The organization and content of this latest edition are identical to the abovementioned texts, with 18 distinct chapters. The outline format of the text is identical to that seen in all prior editions, but the content has been significantly updated. Although the photographic reproductions are slightly smaller than those in
DOUBLE-HEADED MONSTERS IN FICTION.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ENDOCRINOLOGY AND OTOLARYNGOLOGY
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diving Medicine
Authors: Robert W. Goldmann
Journal: JAMA (1990)

This 300 +-page overview of diving medicine is written with an emphasis on the sport scuba diver. Many of the authors who contributed chapters have extensive experience in the field and have either contributed to or been extensively cited in previous established diving reference texts, including<i>The Physician's Guide to Diving Medicine</i>, edited by Charles W. Shilling, and<i>Diving and Subaquatic Medicine</i>, edited by Carl Edmonds. The book is well organized and has a somewhat novel classification by organ system of many of the diving disorders. Specific chapters on ear and sinus pathology, pulmonary problems, and the cardiovascular system allow a rapid appreciation of the unique aspects of diving medicine. The basic chapters on "Physiology and Physics," "Basic Diving Equipment," and "Mechanisms of Diving Injury" are particularly lucid and serve as an excellent foundation in dive medicine physiology. The book itself makes interesting reading for the diving and nondiving physician
Spontaneous Pneumothorax
Authors: Steven A. Sahn, John E. Heffner
Journal: New England Journal of Medicine (2000)

Pneumothorax is classified as spontaneous (not caused by trauma or any obvious precipitating factor), traumatic, or iatrogenic (Table 1). Primary spontaneous pneumothorax occurs in persons without clinically apparent lung disease; secondary spontaneous pneumothorax is a complication of preexisting lung disease. Iatrogenic pneumothorax results from a complication of a diagnostic or therapeutic intervention. Traumatic pneumothorax is caused by penetrating or blunt trauma to the chest, with air entering the pleural space directly through the chest wall; visceral pleural penetration; or alveolar rupture due to sudden compression of the chest. In this review we focus on spontaneous pneumothorax.Primary Spontaneous PneumothoraxEpidemiology . . .
Laboratory diagnosis of hepatitis B
Authors: J. Ahtone
Journal: JAMA (1983)

The recent advances in the laboratory diagnosis of hepatitis B have caused considerable confusion regarding what the various laboratory test results actually tell the physician. This article explains, in a nontechnical fashion, what the various test results mean. Included is a flowchart that explains, for general physicians, the interpretation of test results and the public health implications of serological findings as they relate to hepatitis B. (<i>JAMA</i>1983;249:2067-2069)
In this issue
Authors: Peter Kirkpatrick, Alexandra Flemming, Charlotte Harrison, Sarah Crunkhorn, Monica Flight, Asher Mullard, Mariam Faruqi, Man Tse, Catriona Rodwell, Lucie Wootton, Lewis Packwood, Susanne Harris, Vicky Summersby, Patrick Morgan, Kirsten Lee, Judith Shadwell, Simon Fenwick, Natalie Smith, Laura Corns, Deborah Anthony, Tim Redding, Virginia Lee, Peter Collins
Journal: Nature Reviews Drug Discovery (2012)
PRAGUE
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Engineering and the Use of Bovine Somatotropin
Authors: Charles J. Grossman
Journal: JAMA (1990)

During the last decade there has been an unfortunate reappearance in our society of an antitechnology and antiscience attitude. This is exemplified by those advocates who would ban all animals in research and block fetal tissue studies and by those who support creationism. An especially vocal group consists of those people who are against any form of genetic engineering regardless of the benefits or potential benefits that might be realized. We can find no better example of the genetic engineering controversy than that epitomized by the furor currently surrounding the use of bovine somatotropin (growth hormone) in dairy cows. Manufactured by Monsanto, American Cyanamid, Eli Lilly, and Upjohn, the drug will not become commercially available until the end of 1990 when Food and Drug Administration approval is expected.<sup>1-3</sup>However, it has been extensively studied for the past 5 years and can clearly increase milk production by at least 14%.