tbuckley/cabot-search huggingface dataset:
Juvenile Mental Health Histories of Adults With Anxiety Disorders
Authors: Alice Gregory
Journal: American Journal of Psychiatry (2007)

Objective: Information about the psychiatric histories of adults with anxiety disorders was examined to further inform nosology and etiological/ preventive efforts. Method: The authors used data from a prospective longitudinal study of a representative birth cohort (N=1,037) from ages 11 to 32 years, making psychiatric diagnoses according to DSM criteria. For adults with anxiety disorders at 32 years, follow-back analyses ascertained first diagnosis of anxiety and other juvenile disorders. Results: Of adults with each type of anxiety disorder, approximately half had been diagnosed with a psychiatric disorder (one-third with an anxiety disorder) by age 15. The juvenile histories of psychiatric problems for adults with different types of anxiety disorders were largely nonspecific, partially reflecting comorbidity at 32 years. Histories of anxiety and depression were most common. There was also specificity. For example, adults with panic disorder did not have histories of juvenile disorders, whereas those with other anxiety disorders did. Adults with posttraumatic stress disorder had histories of conduct disorder, whereas those with other anxiety disorders did not. Adults with specific phobia had histories of juvenile phobias but not other anxiety disorders. Conclusions: Strong comorbidity between different anxiety disorders and lack of specificity in developmental histories of adults with anxiety disorders supports a hierarchical approach to classification, with a broad class of anxiety disorders having individual disorders within it. The early first diagnosis of psychiatric difficulties in individuals with anxiety disorders suggests the need to target research examining the etiology of anxiety disorders and preventions early in life.
Symptomatic Early Neurosyphilis Among HIV-Positive Men Who Have Sex With Men—Four Cities, United States, January 2002–June 2004
Journal: JAMA (2007)

SYMPTOMATIC EARLY NEUROSYPHILIS IS A rare manifestation of syphilis that usually occurs within the first 12 months of infection. 1Most neurologic symptoms of early neurosyphilis result from acute or subacute meningitis, abnormalities in cranial nerve function, and inflammatory vasculitis leading to a cerebrovascular accident.2][3] The disease burden from neurosyphilis is unknown because national reporting of this disease is incomplete.Because the increase in syphilis cases during the past 5 years has occurred primarily among MSM, many of whom were infected with HIV, CDC conducted a review of possible neurosyphilis cases to describe the clinical course of symptomatic early neurosyphilis and to better characterize the risk for this illness among HIV-infected MSM.The review included health department records from four U.
Computers in Medicine
Authors: Donald B. Louria
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Extraordinary advances are being made in computer technology. The derivative question is whether we are using that computer capability as effectively as we should for health purposes. It seems to me there are two areas in which we should surely use our computer capabilities more extensively. The first relates to potential illnesses caused by workplace exposure. More than 50,000 chemicals are in use in this country, and there are virtually daily pronouncements concerning the dangers of some of them to workers and sometimes to the public. Many companies have sedulously attempted to improve workplace health conditions. Others are absolutely intransigent in refusing to permit any investigation, even after evidence is presented suggesting strongly that their employees have health problems (particularly a higher cancer incidence) that merit analysis. The number of investigations needed is so large that our present regulatory agencies cannot even begin to cope with the
Treatment of hyperthyroidism with sodium iodide I-131
Authors: M. M. Nofal
Journal: JAMA (1966)

The incidence of hypothyroidism among 848 patients treated for hyperthyroidism with sodium iodide I 131 has been compared with the incidence among 121 patients treated for hyperthyroidism surgically. During follow-up periods ranging from less than a year to 16 years, at least 51% of those treated with sodium iodide I 131 and 28% of those surgically treated became hypothyroid. After the first year of follow-up study, the cumulative incidence of hypothyroidism increased 2.8% per year in the group treated with the radioactive compound and 1.7% in the group surgically treated. It is also estimated that within the first ten years after treatment, 70% of the group treated with sodium iodide I 131 and 43% of the group surgically treated will have become hypothyroid.
Pros and cons on NIH consensus conferences
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Integrating geriatric assessment into routine gastrointestinal (GI) consultation: The Cancer and Aging Resilience Evaluation (CARE).
Authors: Grant Richard Williams, Kelly Kenzik, Mariel Parman, Gabrielle Betty Rocque, Andrew Michael McDonald, Ravi Kumar Paluri, Rudolph M. Navari, Lakshminarayanan Nandagopal, Crystal Young Smith, Matthew Robertson, Smita Bhatia
Journal: Journal of Clinical Oncology (2019)

667 Background: Integrating Geriatric Assessment (GA) in the management of older adults with cancer is recommended, yet rarely practiced in routine oncologic care. In this report, we describe the feasibility of integrating the routine incorporation of GA in the management of older adults with GI malignancies and characterize GA impairments. Methods: CARE was adapted from the Cancer and Aging Research Group GA with modifications to create a completely patient-reported version. The CARE assesses self-reported functional status, physical function, nutrition, social support, anxiety/depression, cognitive function, comorbidities, and social activities. Patients ≥ 60yo referred for consultation to the GI Oncology clinic were asked to complete the CARE (paper/pencil) on their first visit. The completed CARE was collected during nurse triage and submitted to the clinical team prior to the physician encounter. Feasibility was defined as completion of the CARE by ≥ 80% of eligible patients during the initial consultation. Results: Between September 2017 and August 2018, 199 eligible new patients attended the GI Oncology Clinic, 192 (96.5%) were approached, and 181 (90.4%) completed the CARE. Most patients (79.6%) felt the length of time to complete was appropriate (median time of 10 minutes [IQR 10-15 minutes]). The mean age was 70y (range 60-96), 54.3% were male, and 75.1% were non-Hispanic white. Common tumor types included colon (27.8%), pancreatic (21.2%), and rectal (10.2%) cancer; predominately advanced stage diseases (stage III: 26.9%; stage IV: 40.0%). GA impairments were prevalent: 48.6% reported dependence in Instrumental Activities of Daily Living, 18.0% reported dependence in Activities of Daily Living, 22.5% reported ≥ 1 fall, 29.4% reported a performance status ≥ 2, 51.3% were limited in walking one block, 75.7% reported polypharmacy (≥ 4 medications), and 84.3% had ≥ 1 comorbidity. Conclusions: Performing a GA in the routine care of older adults with GI malignancies is feasible, and GA impairments are common among older adults with GI malignancies. A fully patient-reported GA such as the CARE may facilitate broader incorporation of GA in the routine clinic work flow.
Abstract 2463: Prototype open-access biomarker knowledgebase for genetic tests for breast cancer
Authors: Dara Baker, Natalie Fedorova Abrams, Amanda Bell, Maureen Colbert, Hayley Dingerdissen, Evan Holmes, Samir Gupta, Robel Kahsay, Heather Kincaid, David Liu, A. S. M. Ashique Mahmood, Frédéric B. Bastian, Marc Robinson-Rechavi, Elena Schwartz, K. Vijay-Shanker, Daniel Crichton, Raja Mazumder
Journal: Cancer Research (2019)

Abstract Cancer biomarkers have become integral components of many clinical protocols and research studies. Nonetheless there still is an urgent need for more accurate, less invasive, and cost-effective biomarker tests to advance precision oncology. Despite considerable success in the preclinical setting, most candidate biomarker tests have yet to receive regulatory clearance or approval and gain market acceptance. To better understand the challenges facing modern biomarker research and facilitate access to biomarker-related information, this study aims to delineate the paths to approval of genetic tests for breast cancer. Public databases were searched to identify approved tests and respective biomarkers. A prototype format for unified biomarker information was developed iteratively due to the highly variable presentation of this data. A knowledgebase of FDA-approved genetic biomarkers for breast cancer was built as a pilot implementation of this format. This model is extensible to a larger database of biomarkers to be hosted in OncoMX (https://oncomx.org), which integrates cancer mutation, differential expression, literature mining, and pathway information. Fields in the prototype database were populated based on findings from the FDA website, PubMed, and other open-source databases. The resulting dataset is structured with the corresponding readme following the BioCompute Object (BCO) model. This BCO-compliant approach enables provenance capture and transparency of data processing, both of which are critical to large-scale data integration efforts. The adherence to BCO standards is expected to enhance the usability of the resulting data and to streamline the subsequent integration of multiple biomarker datasets. In the rapidly evolving field of oncologic biomarker research, this open-source biomarker knowledgebase offers clinicians and researchers a streamlined access to genetic tests information including corresponding genes, guides to evidence, clinical trial data, links to archival databases, and context for the behavior of the implicated gene in other disease and normal processes. Citation Format: Dara Baker, Natalie Fedorova Abrams, Amanda Bell, Maureen Colbert, Hayley Dingerdissen, Evan Holmes, Samir Gupta, Robel Kahsay, Heather Kincaid, David Liu, A. S. M. Ashique Mahmood, Frédéric B. Bastian, Marc Robinson-Rechavi, Elena Schwartz, K. Vijay-Shanker, Daniel Crichton, Raja Mazumder. Prototype open-access biomarker knowledgebase for genetic tests for breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2463.
Clinical Use of Pig Liver Perfusion
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute appendicitis, perforation, and small-bowel obstruction in an infant
Authors: H. W. Lee
Journal: JAMA (1986)

APPENDICITIS in infancy is uncommon, difficult to diagnose, and associated with significant morbidity and mortality.<sup>1</sup>Conical configuration of the appendix makes obstruction of the lumen unlikely in this age group.<sup>2</sup>Because of the inability of the patient to give a coherent history, other symptoms become significant features in diagnosis.<sup>3</sup>Mechanical small-bowel obstruction as a presenting symptom complex in acute appendicitis in infancy is rare. <h3>Report of a Case</h3> An 8-month-old male infant was admitted because of persistent vomiting and diarrhea for four days. On preliminary examination, the infant was seen to be drowsy and lethargic, with signs of advanced dehydration. He was afebrile. His neck was supple and his chest was clear. The abdomen was soft, showing no tenderness or organomegaly. The clinical impression on admission was gastroenteritis. Lumbar puncture was performed to rule out meningitis, and intravenous fluids were administered. By next morning, the infant had
Medical preparation for the Olympic Games
Authors: M. H. Stiles
Journal: JAMA (1968)

In past Olympiads, the US Olympic Medical and Training Services Committee functioned primarily as a personnel selection and supply committee of lay members—with medical problems handled by team physicians. The prospect of having to compete at Mexico City in the XIX Olympiad introduced two major problems, that of competing at an altitude considerably higher than that of any previous summer games and the well-recognized problem of enteritis. The primary step taken by the US Olympic Committee to meet these challenges was the appointment of a broad-based Medical and Training Services Committee, after consultation with the American College of Sports Medicine, the American Medical Association Committee on the Medical Aspects of Sports, other organizations, and numerous individuals. Because of the physiologic problems which were anticipated, an Advisory Panel on Sports Physiology was also appointed. An early responsibility of the Medical and Training Services Committee was the selection of medical, nursing, and
Noises
Authors: John Savoie
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2015)

Epidemiologic evidence supports an association of regular physical activity with lower rates of cognitive decline.Sink and colleagues investigated this relationship in a clinical trial involving 1635 community-dwelling sedentary adults aged 70 to 89 years who were randomly assigned to a 24-month structured, moderate-intensity physical activity program or to a health education program.The authors report that compared with health education, the 24-month physical activity program did not result in improvements in global or domain-specifi c cognitive function.In an Editorial, Gill and Seitz discuss lifestyle factors and cognitive health.
HIV Testing
Authors: Elaine M. Sloand
Journal: JAMA (1991)

TECHNOLOGY for detecting the antibody to human immunodeficiency virus type 1 (HIV-1), the etiologic agent of the acquired immunodeficiency syndrome (AIDS), was first licensed by the Food and Drug Administration (FDA) in 1985. Since then, the spread of the AIDS epidemic from subpopulations, such as male homosexuals, drug abusers sharing contaminated needles, and female prostitutes, to other people with less obvious risk factors has underscored the need for accurate testing to detect infection with HIV-1. The appreciation that people who test positive for HIV-1 can infect others<sup>1,2</sup>and the demonstration that infected individuals can benefit from early detection and treatment<sup>3-5</sup>have further accentuated this need. Although the first test developed was extremely effective in detecting HIV-1 in patients with AIDS, developing tests for screening healthy people has presented a different challenge. A test that could detect small amounts of HIV-1 early in asymptomatic persons and a confirmatory test
Association of plasminogen-activator inhibitor 1 (PAI-1) 4G/5G gene polymorphism with survival and chemotherapy-related vascular toxicity in non-seminomatous testicular cancer (TC)
Authors: E. C. de Haas, N. Zwart, C. Meijer, H. M. Boezen, A. J. Suurmeijer, J. van der Meer, H. J. Hoekstra, F. E. van Leeuwen, D. T. Sleijffer, J. A. Gietema
Journal: Journal of Clinical Oncology (2009)

5083 Background: High PAI-1 expression by tumor has been associated with poor prognosis in different cancer types, while high systemic PAI-1 levels may increase the risk of vascular thrombosis. We investigated whether the 4G/5G del/ins polymorphism in the PAI-1 promoter (rs1799889; 4G might lead to higher transcription), is associated with differences in survival and prevalence of cardiovascular events in TC. Methods: Data were collected on survival and cardiovascular events (venous thromboembolism [VTE] and coronary heart disease [CHD]) of TC patients treated with standard platinum based chemotherapy from 1977–2004. PAI-1 genotype was determined from non-tumor genomic DNA by a Taqman SNP assay. Genotypes were compared for survival (Kaplan-Meier curves + log-rank and Cox-regression analysis), disease outcome (logistic regression) and prevalence of VTE and CHD (χ 2 -test). Results: Data are available for 324 patients with median follow-up of 10 yrs (range 0–28). The 3 genotypes 4G/4G (n = 84), 4G/5G (n = 164), and 5G/5G (n = 76) do not differ in age and initial chemotherapy regime. However, the 4G/4G variant shows a higher prevalence of International Germ Cell Cancer Classification (IGCCC) poor prognosis compared to 4G/5G + 5G/5G (24% vs 10%; p = 0.003), as well as a decreased TC related survival compared to 4G/5G + 5G/5G (83% vs 94%; p = 0.001) with a hazard ratio of 2.68 for TC related death (95%CI 1.26–5.72; adjusted for IGCCC p = 0.011). In addition, the 4G/4G variant shows an odds ratio of 3.35 for refractory TC and early relapses (&lt;2 yrs) (95% CI 1.48–7.58; p = 0.004). The 3 genotypes do not differ significantly in prevalence of VTE (4G/4G 11.9%, 4G/5G 8.5%, 5G/5G 7.9%; p = 0.616) and CHD during/after chemotherapy (4G/4G 6.0%; 4G/5G 4.9%; 5G/5G 2.6%; p = 0.594). Conclusions: The 4G/4G variant of the PAI-1 4G/5G gene polymorphism is associated with IGCCC poor prognosis, reduced survival and higher prevalence of refractory disease and early relapses. No effect on vascular toxicity was found. The 4G/4G variant of the PAI-1 gene may be an unfavorable prognostic factor as well as an unfavorable predictive factor for response to chemotherapy in patients with TC. No significant financial relationships to disclose.
2 Classification of juvenile idiopathic arthritis
Authors: M LANGKAMMERER, R HÄFNER, R MORHART
Journal: Annals of the Rheumatic Diseases (2000)

with periodic fever and a high serum IgD, mevalonate kinase was genetically and enzymatically normal, ruling out Dutch-type periodic fever.Conclusion-Children with unexplained recurrent fevers should be tested for mevalonate kinase deficiency irrespective of serum IgD.Molecular diagnosis can positively identify patients with Dutch-type periodic fever and should serve as a starting point for future trials.
The Twelfth Annual Report of the State Board of Health of Indiana for the Year 1893.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Can the external peer review process provide adequate feedback to sustain the implementation of the heart failure guidelines by primary care providers? Judy D. Wiles, Jaspal S. Samra, Ruyayya Gill, Prakash C. Deedwania. VA Central California Health Care System, Fresno, CA, UCSF School of Medicine, San Francisco, CA
Journal: Journal of the American College of Cardiology (2001)
The sick sinus syndrome in atrial disease
Authors: M. I. Ferrer
Journal: JAMA (1968)

Although little basic information exists regarding atrial disease, certain clinical states can be grouped into a syndrome resulting from a failing sinoatrial (SA) node. One or more of the following symptoms appears: persistent, severe, and unexpected sinus bradycardia; cessation of sinus rhythm for short intervals with other rhythms supervening; long periods of sinus arrest without rescue rhythm, which produces cardiac arrest; untreated chronic atrial fibrillation with slow ventricular rate; no sinus rhythm after cardioversion; SA exit block. Symptoms spring from hypoperfusion of vital organs.