tbuckley/cabot-search huggingface dataset:
Exercise-Associated Hyponatraemia after a Marathon: Case Series
Authors: A M Goudie, D S Tunstall-Pedoe, M Kerins, J Terris
Journal: Journal of the Royal Society of Medicine (2006)

To review the presentation, treatment and response of those runners from the London Marathon who presented to St Thomas' Hospital with exercise induced hyponatraemia.Observational case series.St Thomas' Hospital, a tertiary hospital situated near the finish line of the 2003 London Marathon.All runners who presented to St Thomas' Hospital on the day of the 2003 London Marathon with altered mental state whose serum sodium concentration was less than 135 mmol/L.Presenting symptoms, volume and type of fluids administered and response to treatment (biochemical and clinical).Fourteen patients were diagnosed with exercise associated hyponatraemia with serum sodium concentrations ranging from 116 to 133 mmol/L. Eleven presented with confusion. There were long delays between the finish time and presentation time for some runners. Anecdotal descriptions suggested some runners finished the race with normal mental state then became confused. There was no correlation between running time and serum sodium level. All patients received 0.9% saline and six received 1.8% saline. Despite this, some patients demonstrated falls in serum sodium concentrations. Thirteen to fourteen patients were symptomatically well the following morning, with the remaining patient significantly improved.Presentation of exercise associated hyponatraemia may be delayed. Optimal treatment is controversial, but the use of isotonic saline may not result in rises of serum sodium and we would suggest the early use of hypertonic fluids in symptomatic patients.
Molly
Authors: Peter D. Rogers
Journal: JAMA (1983)

Molly Casey was blond and small and had eight freckles on her nose. She had brilliant green eyes and the middle of her upper lip was pinched just a little and turned up as if she were always preparing to kiss someone. Molly had been my patient since she was 12. Molly had a way of getting things she wanted. She called them her "routines." Her "Camille routine" was used when she was sick. It was a series of emotive posturings that made it seem as if her death was imminent. I saw her use it convincingly once in my office in front of her mother. I never saw what she called her "Mary Poppins routine" or, after she read<i>Catcher in the Rye</i>, her "Holden Caulfield routine." During one of Molly's office visits when she was 15, her mother complained that she couldn't get Molly "out of blue jeans
Legionella pneumophila wound infection
Authors: W. Brabender
Journal: JAMA (1983)

<i>LEGIONELLA pneumophila</i>pneumonia was first recognized after the outbreak that followed the 1976 convention of the Pennsylvania Department of the American Legion in Philadelphia.<sup>1</sup>After the recognition of<i>L pneumophila</i>in causing pneumonia, a respiratory illness without pneumonia termed "Pontiac fever" was shown to be caused by the same agent.<sup>2</sup>Later,<i>L pneumophila</i>was demonstrated in tissues other than the lungs of patients who had pulmonary infiltrates, a finding that suggested hematogenous dissemination.<sup>3</sup>Vascular access sites in patients undergoing renal dialysis may also be infected.<sup>4</sup>From a perirectal abscess in one patient,<i>L pneumophila</i>and anaerobes were isolated.<sup>5</sup> We describe a patient without pneumonia from whom cultures of an open wound showed growth of<i>L pneumophila</i>and<i>Pseudomonas aeruginosa</i>. Apparently the<i>L pneumophila</i>was acquired by the patient from water in a Hubbard tank in which he was receiving daily rehabilitation. Routine disinfection of the
Clinical significance of Koebner’s phenomenon in vitiligo
Authors: N. van Geel, R. Speeckaert, J. De Wolf, S. Bracke, I. Chevolet, L. Brochez, J. Lambert
Journal: British Journal of Dermatology (2012)

Bulleted statements1. What's already known about this topic?The clinical significance of Koebner's phenomenon in vitiligo with respect to disease activity, course and therapeutic response is still debatable.Recently, a new classification is introduced for the assessment of Koebner's phenomenon.So far, studies evaluating KP in daily practice using this new evaluation system are not available in the literature. What does this study add?Our results support the hypothesis that Koebner's phenomenon may function as a clinical parameter to assess and predict the clinical profile and course of vitiligo.
Radiology
Authors: Ronald G. Evens
Journal: JAMA (1996)

This past year was very special for radiology, one of the few medical specialties that can state precisely the date of its beginning, because 1995 was the 100th anniversary of Professor Wilhelm Conrad Röntgen's discovery of the X ray in a physics laboratory in Würzburg, Germany. This centennial was celebrated with special lectures, presentations, and exhibits throughout the world by radiologists, scientists, and their colleagues. The celebration included a Roentgen Centennial issue of<i>JAMA</i>on September 20, 1995.<sup>1</sup>For this issue of Contempo, developments in magnetic resonance angiography (MRA), image-guided therapy, and imaging on the Internet are summarized. Magnetic resonance imaging (MRI) has been capable of identifying blood flow and the anatomy of larger blood vessels since its inception, and a series of technical improvements during the past 2 years has improved the spatial resolution of MRI enough to make MRA of increasing clinical interest for diagnosis in many
Medical Toxicology
Authors: William Banner
Journal: JAMA (1994)

Medical toxicology as a recognized subspecialty of medicine was given a recent boost with the development of a subspecialty credentialing process under the aegis of the American Board of Medical Specialties. Recognizing the prior work done by the American Board of Medical Toxicology to maintain an eclectic base of support for medical toxicology, the American Board of Emergency Medicine, the American Board of Pediatrics, and the American Board of Preventive Medicine will jointly sponsor an examination that will be administered in November 1994. Physicians in these and in other, nonsponsoring specialties may take the examination. In recognition of these changes, the American Board of Medical Toxicology has formally changed its name to the American College of Medical Toxicology to reflect that its continued mission will not duplicate the efforts of the subboard in medical toxicology. The science of toxicology has advanced during the 2 years since the last toxicology review
Cytomegalovirus is not an occupational risk for nurses in renal transplant and neonatal units. Results of a prospective surveillance study
Authors: C. L. Balfour
Journal: JAMA (1986)

The risk of inpatient-to-nurse transmission of cytomegalovirus (CMV) was assessed in a five-year prospective seroepidemiologic study. We enrolled 263 renal transplant/hemodialysis nurses, 204 neonatal intensive care nurses, 225 student nurses, and 251 blood donor controls. Prevalence of CMV antibody in these 943 subjects was 33.7% and did not differ significantly among the four study groups. Sixteen subjects experienced primary CMV infections. The yearly seroconversion rate, calculated from age-related seroprevalence data, was 1.9%. The rate of seroconversion during the study, established by observing 519 seronegative subjects for 10 420 person-months, was 1.84% per year and did not differ significantly among the study groups. The proportions of patients with CMV infection (1.1% to 11.9%) and disease (0.5% to 3.4%) on study wards were not related to seroconversion in the nurses. The slow rate of acquisition of CMV in susceptible adults suggests that transmission requires prolonged, intimate contact. Nurses and nursing students who practice good personal hygiene are no more likely to acquire CMV than their peers in the community. (<i>JAMA</i>1986;256:1909-1914)
Response: Re: Cost-Effectiveness of Computed Tomographic Colonography Screening for Colorectal Cancer in the Medicare Population
Authors: A. B. Knudsen, I. Lansdorp-Vogelaar, C. M. Rutter, J. E. Savarino, M. Van Ballegooijen, K. M. Kuntz, A. G. Zauber
Journal: JNCI Journal of the National Cancer Institute (2010)

ResponsePickhardt et al. criticize our natural history assumptions for small (<6 mm) adenomas.The natural history of adenomas of different sizes is unknown.Our three independently developed models differ widely with respect to the natural history of small adenomas, namely whether and how quickly they progress to colorectal cancer.Despite these differences, our models generated consistent conclusions about the cost-effectiveness of computed tomographic colonography (CTC) screening.
Differences in mortality from coronary artery bypass graft surgery at five teaching hospitals
Authors: S. V. Williams
Journal: JAMA (1991)

<h3>Objective.</h3> —To measure hospital- and surgeon-specific mortality rates for patients with coronary artery bypass graft (CABG) surgery and to examine possible reasons for any differences. <h3>Design.</h3> —Cohort study using hospital discharge abstracts and itemized bills. <h3>Setting.</h3> —Five major teaching hospitals in Philadelphia, Pa. <h3>Patients.</h3> —Consecutive sample of all 4613 patients over a 30-month period. <h3>Main Outcome Measure.</h3> —In-hospital mortality rates. <h3>Results.</h3> —We observed differences in hospital mortality rates for patients who underwent coronary artery catheterization and CABG surgery during the same admission (diagnosis related group 106) but not for patients who underwent only CABG surgery during the admission (diagnosis related group 107). There were threefold differences in surgeon-specific mortality rates. The hospital mortality rates for coronary artery catheterization and CABG surgery during the same admission changed during the study and coincided with moves of surgeons among study hospitals. Our measures of illness severity did identify patients who were more likely to die, but differences in severity of illness did not explain differences in hospital- or surgeon-specific mortality rates. Patient mortality rates were not associated with the volume of procedures performed by individual surgeons. We found inconclusive evidence for an association with surgeons' clinical skills, and, to a lesser extent, with the hospital's volume of procedures and the hospital's organization and staffing. A greater intensity of hospital services was not necessary for a lower mortality rate. <h3>Conclusions.</h3> —We conclude that studies of CABG mortality should examine mortality rates by diagnosis related group, collect data from more than 1 year, examine associations with surgeons' clinical skills, include information on hospital organization and staffing, and cautiously explore more efficient ways of providing care. (<i>JAMA</i>. 1991;266:810-815)
Kurzes Handbuch der Ophthalmologie.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surgery, Gynecology and Obstetrics, Chicago
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AS TO ALCOHOL.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Problems in diagnosing halothane hepatitis
Authors: C. Lomanto
Journal: JAMA (1970)

Halothane was believed to be the offending agent in five cases of suspected hepatitis. All the patients were women. Two had chronic active hepatitis proved by liver biopsy, but the diagnosis in the other three, including the woman who died, was not clearly established. Until a specific test for viral or halothane hepatitis is developed, the use of halogenated agents in any patient with known liver disease, sepsis, or a recent history of flu-like symptoms should be avoided. An arbitrary three-month period is observed between repeated halothane anesthesias.
Clinical Use of Apolipoprotein Quantitation
Authors: Daniel J. Rader
Journal: Annals of Internal Medicine (1995)

Letters1 January 1995Clinical Use of Apolipoprotein QuantitationDaniel J. Rader, MDDaniel J. Rader, MDUniversity of Pennsylvania Medical Center; Philadelphia, PA 19104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-1-199501010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In our proposed algorithms, HDL cholesterol levels are initially determined as part of the fasting lipid panel. We agree that a decision to use drug therapy because of a low HDL cholesterol level could obviate the need for further apolipoprotein quantitation. However, because drug therapy for a low HDL cholesterol level is not established practice, we feel that the additional data provided by the apo B and Lp(a) levels cold be useful in determining drug therapy for persons with low HDL cholesterol levels.Two unfortunate misprint appeared in our review. As Dr. Padder and colleagues and Dr. Johnson ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania Medical Center; Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1995Volume 122, Issue 1Page: 69-70KeywordsAlgorithmsApolipoproteinsCholesterolCoronary heart diseaseDrug therapyHigh density lipoproteinLipidsLongitudinal studiesMortalityStable coronary artery disease Issue Published: 1 January 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Penicillins
Authors: L. P. Garrod
Journal: BMJ (1966)

<h3>SUMMARY</h3> X chromosome inactivation (XCI) is a developmental regulatory process that initiates with remarkable diversity in various mammalian species. Here we addressed the contribution of XCI regulators, most of which are lncRNA genes characterized in the mouse, to this mechanistic diversity. By combining analysis of single-cell RNA-seq data from early human embryogenesis with various functional assays in naïve and primed pluripotent stem cells and in differentiated cells, we demonstrate that <i>JPX</i> is a major regulator of <i>XIST</i> expression in human and in mouse. However, the underlying mechanisms differ radically between species and require <i>Jpx</i> RNA in the mouse and the act of transcription of <i>JPX</i> locus in the human. Moreover, biogenesis of <i>XIST</i> is affected at different regulatory steps between these species. This study illustrates how diversification of LRGs modes of action during evolution provide opportunities for innovations within constrained gene regulatory networks. <h3>Graphical abstract</h3>
"Match" Made in Heaven?
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Reply:
Authors: Young Kwok, Roy A. Patchell, William F. Regine
Journal: Journal of Clinical Oncology (2005)

We would like to respond to several points raised by both groups regarding our editorial and the Maranzano et al study. 1,2 We find it strange that some of our European colleagues equate the safety and equivalency of hypofractionated schedules in bone and lung metastases as a justification for the safety of such regimens in malignant cord compression (MCC). [3]4][5] This is analogous to comparing apples and oranges.Even though overall pain and survival times are not different, it is well-recognized that
Measles, a renewed challenge
Authors: A. J. Finkel
Journal: JAMA (1971)

When Rhazes (860-932 AD), a physician living in the Eastern Caliphate in Persia, distinguished measles from smallpox, he provided the first accurate description of an ancient and widespread infectious disease. A relatively mild disease primarily affecting children in developed countries, it can be serious and devastating in less-well-developed lands and can be the cause of serious epidemics among nonimmune adults in isolated populations. Despite its relative mildness in recent years in countries such as the United States, measles is known to have a number of serious complications such as pneumonia, severe bronchitis, and bronchiolitis; otitis media; and encephalitis, mental retardation, behavior changes, and motor disturbances.<sup>1</sup>Rarer complications include purpura, corneal ulceration, pneumomediastinum, and even appendicitis. Before the licensure of an attenuated live virus vaccine in 1963, more than 4 million cases of measles are estimated to have occurred annually in the United States of which 400,000 were reported. At
INCREASED REGURGITANT FLOW CAUSES ENDOCARDIAL CUSHION DEFECTS IN AN AVIAN EMBRYONIC MODEL OF CONGENITAL HEART DISEASE
Authors: Stephanie Ford, Matthew T. McPheeters, Yves T. Wang, Shi Gu, Yong Qiu Doughman, James Strainic, Andrew M. Rollins, Michiko Watanabe, Michael Jenkins
Journal: Journal of the American College of Cardiology (2016)
Differentiating dementia from normal
Authors: R. J. Branconnier
Journal: JAMA (1985)

<h3>In Reply.—</h3> It appears that Mr Branconnier has misinterpreted the thrust of our article and the nature and purpose of our screening test.<sup>1</sup>It is not designed to "diagnose" dementing illness but to identify older persons who deserve to have the benefit of comprehensive diagnostic studies. A positive result on the test would raise the suspicion that some form of mental decline, temporary or not, may be occurring and that medical attention and further psychological assessment should be considered. A false-positive finding would be clarified as such rather rapidly, most likely in a first medical interview, without any serious financial, psychological, or social consequences ensuing. In fact, the contrary might occur. Persons scoring as a false-positive may do so because of social, psychological, or medical problems, eg, depression, that may well benefit from medical attention. The letter reveals some misconceptions about dementia that deserve noting. First, there is insufficient