tbuckley/cabot-search huggingface dataset:
Choledochal Cystadenoma
Authors: A. Hedayat, R. Sotoudehmanesh, M. Khatibian, H. Mahmoodzadeh, M. Sotoudeh
Journal: Endoscopy (2005)

Figure 1 A 42-year-old woman presented with jaundice, right upper quadrant pain and pruritus. Laboratory test findings were: hemoglobin (Hb) 11.1; bilirubin 4.6; aspartate aminotransferase (AST) 34; alanine aminotransferase (ALT) 38; prothrombin time (PT) 16; and alkaline phosphatase 1083. Abdominal sonography revealed dilatation of the intra- and extrahepatic biliary ducts. Endoscopic retrograde cholangiopancreatography (ERCP) showed dilated bile ducts with a large lobulated filling defect in the proximal portion of the common bile duct toward the intrahepatic ducts. CBD, common bile duct; CHD, common hepatic duct.
Christmas in the Hospitals.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ACID FACTOR IN PEPTIC ULCER
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Feebleness of Growth and Congenital Dwarfism with Special Reference to Dysostosis Cleido-Cranialis.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Organizing house officers
Authors: F. Mullan
Journal: JAMA (1970)

Working with an acutely ill patient late at night on the back wards of a city hospital, with no nursing care, minimal laboratory support, and pathological conditions that should have been noticed months before were there adequate screening clinics, the young intern or resident feels far removed from the process of medical education. Even under the relatively more auspicious circumstances under which most house officers pass their period of post-graduate training, there is the sense of being removed from the structured and formalistically didactic medical school situation. Its demands, its rewards, its circumstances, and its style combine to make house officership an experience relatively more involved and less pristine than its undergraduate predecessor. There is no debate that house officership is an educational experience, but unlike medical school, it is also a service experience and a commitment of work to patient and community alike. It is heartening that the Council
Acta Anaesthesiologica Scandinavia, Aarhus
Journal: JAMA (1964)

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P49 * SENSITIZING GLIOBLASTOMA CELLS TO THERAPY BY TARGETING THE L-GLUTAMATE/L-CYSTINE ANTIPORTER SYSTEM XC-
Authors: A. Kolb, S. Piccirillo, C. Watts
Journal: Neuro-Oncology (2014)

INTRODUCTION: System xc-(SXC),a L-cystine/L-glutamate antiporter represents the primary non-vesicular route of glutamate release. Certain cancers,such as Glioblastoma multiforme(GBM),are unable to synthesise sufficient concentrations of L-cysteine,rendering them dependent on L-cystine influx via SXC. GBM is the most common type of brain tumour with a median survival of only 15 months, partly due to its high resistance to conventional therapy. SXC may contribute to the former,as L-cystine is essential for generation of Glutathione,which is involved in removal of xenobiotics. The FDA-approved SXC antagonist Sulfasalazine(SSZ) may be implemented to lower resistance to therapy in GBM. Therefore, I ascertained SXC expression in GBM and investigated the effect of SSZ on tumour viability and growth. METHOD: Expression of SXC and the effect of SSZ in combination with conventional treatment were analysed by immunostaining, Flow cytometry, Western Blot and qPCR of surgical specimen and patient-derived lines. Moreover,a pharmakokinetic study was carried out to assess bioavailability of SSZ and its metabolites in the brain. RESULTS: In vitro experiments show that targeting SXC with SSZ, while concomitantly treating with temozolomide, leads to a significant attenuation in growth and viability in vitro when compared to temozolomide treatment alone. CONCLUSION: The evidence collected,strongly hints towards an important role of SXC in conveying resistance to conventional therapy in GBM. Therefore, targeting the antiporter in vivo may confer a beneficial effect on survival. In future work the efficacy of combined treatment with SSZ and temozolomide will be evaluated in vivo,in order to indicate if there is any clinical utility.
A Correction of Dr. Cotton's Statement
Authors: George Moyse, Wal- Tham Henry, T Dyson, Hudson Middlesex, Hilton - Lewis, Charles Peters, Ar- Lington Warren, No Middlesex, Joseph Cotton, Lex- Ington Alice, F Pearson, Lowell Middlesex, Walter Perham, Chelms- Ford Gaston, Christian Nelson, Worcester Charles, Ward Johnson, Albert Wheeler, George Nelson, Charles Holden, Thomas Worrell, Athol Worcester, Elbert Crockett, Thomas Johnston, Clinton Warren, E Tarbell, Clifford Chamberlain, Sturbridge Berkshire, J Baker, Harvey Gallup, Adams North, Hampshire Berkshire, Hampden- Frederick Judge, Harry Putnam, William Dubois, West Stockbridge, Hampshire- Cady Elder, Amtierst Hampden, Wesley Hale, Spring- Field Hampden, Walter Grocli, John Shea, Holyoke Middlesex, - Paul Mogan, Waltham Middlesex, - Charles Daly, Charles Coughlin, Michael Hoar, Thomas Dowd, James Mcgrail, Charles Scott, John Weaver, Andrew Leach, Henry Warner, North- Ampton Franklin, John Kane, Hampden No, - David Sullivan, James Sweenev
Journal: New England Journal of Medicine (1928)
Stem Cell Transplantation for Refractory Crohn Disease—Reply
Authors: Christopher J. Hawkey, James Lindsay, John Gribben
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GERMANY
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuel de neurologie. Tome I: L'anatomie du système nerveux: Une tentative de grouper en système fonctionnel les voies et les centres de localisation diverse, par lesquels les diverses impressions sensorielles peuvent se traduire en réactions réflexes. Partie 4: La pars intermedia du tronc cérébral.
Journal: JAMA (1930)

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The Croonian Lectures on the Pulse
Authors: W. H. Broadbent
Journal: BMJ (1887)

THEz subject I have chosen for the lectures which I have the honour to deliver before you, if it is to be judged of by its importance to Ahe medical man, is well worthy of the attention of the College.It is to the pulse that we look first of all for trustworthy i.formation as to the condition of the patient who seeks our aid, and the knowledge obtained from it is a sort of foundation upon which is built up the opinion we form from the collective symptoms he exhibits and from the results of our physical examination.On the other
Use of Anabolic-Androgenic Steroids: We Are Talking Prevalence Rates
Authors: Alice Sigurdson
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The article by Yesalis et al<sup>1</sup>is a timely, descriptive report of AAS use among young adults in the United States. The cross-sectional study design estimates prevalence of AAS use, which is simply the number of persons who ever used AASs divided by the number of persons sampled. The sampling method was complex; however, that is not an issue. Technically, the number derived is a proportion because the numerator is a subset of the denominator.<sup>2,3</sup>The authors report in Table 1 of their article the rate of AAS use as a percentage. The use of rate in this context is troubling on three counts: (1) other researchers, wishing to compare prevalence of AAS use from similar surveys, may decide this comparison is inappropriate because of the use of "rate" in the table and the text; (2) rate implies person-time in the denominator, and it would
Socialized Advertising
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiological and Experimental Studies on the Effects of Methyl Isocyanate on the Course of Pregnancy
Authors: Daya R. Varma
Journal: Environmental Health Perspectives (1987)

Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journals for several months after the accident. We therefore conducted, 9 months after the accident, a preliminary survey of 3270 families in Bhopal and experimental studies on the effects of MIC in pregnant mice. It was found that 43% of pregnancies in women residing near the Union Carbide pesticide plant did not result in the birth of a live child. Likewise, exposure of mice to relatively low concentrations of MIC (9 and 15 ppm) for 3 hr caused complete resorption in more than 75% of animals. A decrease in fetal and placental weights was observed at 2 to 15 ppm MIC. In general, the experimental findings in mice corroborate the epidemiological data from Bhopal. The mechanism of the fetal toxicity of MIC remains to be established.
THE PLAGUE.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SURGICAL CLINICS AT THE WESTERN PENNSYLVANIA HOSPITAL BEFORE THE STUDENTS OF THE WESTERN PENNSYLVANIA MEDICAL COLLEGE
Authors: J. B. MUEDOCH
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology of Radiation-Induced Cancer
Authors: Edward P. Radford
Journal: Environmental Health Perspectives (1983)

The epidemiology of radiation-induced cancer is important for theoretical and practical insights that these studies give to human cancer in general and because we have more evidence from radiation-exposed populations than for any other environmental carcinogen. On theoretical and experimental grounds, the linear no-threshold dose-response relationship is a reasonable basis for extrapolating effects to low doses. Leukemia is frequently the earliest observed radiogenic cancer but is now considered to be of minor importance, because the radiation effect dies out after 25 or 30 years, whereas solid tumors induced by radiation develop later and the increased cancer risk evidently persists for the remaining lifetime. Current estimates of the risk of particular cancers from radiation exposure cannot be fully evaluated until the population under study have been followed at least 40 or 50 years after exposure. Recent evidence indicates that for lung cancer induction, combination of cigarette smoking and radiation exposure leads to risks that are not multiplicative but rather nearly additive.
The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
Authors: Jennifer M. McCoy, Joan R. Wicks, Laurent P. Audoly
Journal: Journal of Clinical Investigation (2002)

Rheumatoid arthritis (RA) is a chronic inflammatory disorder leading to bone and cartilage destruction. A substantial body of evidence suggests that prostaglandin E2 (PGE2) contributes to the pathogenesis of RA, and nonsteroidal anti-inflammatory drugs, inhibitors of the synthesis of PGE2 and other prostanoids, continue to be used in the treatment of this disease. To begin to understand the mechanism by which prostaglandins modulate the pathophysiology of this disease, we examined mice lacking each of the four known PGE2 (EP) receptors after generation of collagen antibody–induced arthritis, an animal model of RA. Homozygous deletion of the EP1, EP2, or EP3 receptors did not affect the development of arthritis, whereas EP4 receptor–deficient mice showed decreased incidence and severity of disease. These animals also showed reduced inflammation as assessed by circulating IL-6 and serum amyloid A levels. Joint histopathology of EP4–/– animals revealed reduced bone destruction, proteoglycan loss, and type II collagen breakdown in cartilage compared with EP4+/+ mice. Furthermore, liver and macrophages isolated from EP4–/– animals produced significantly less IL-1β and IL-6 than control samples. Thus, PGE2 contributes to disease progression at least in part by binding to the EP4 receptor. Antagonists of this receptor might therefore provide novel agents for the treatment of RA.