tbuckley/cabot-search huggingface dataset:
Prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (RCC) treated with vascular endothelial growth factor (VEGF)-targeted agents: Results from a large multicenter study
Authors: D. Y. Heng, W. Xie, M. M. Regan, T. Cheng, S. North, J. J. Knox, C. Kollmannsberger, D. McDermott, B. I. Rini, T. K. Choueiri
Journal: Journal of Clinical Oncology (2009)

5041 Background: Prognostic factors (PF) for OS have yet to be fully defined for patients with metastatic RCC in the era of VEGF-targeted therapy. This study identifies PFs in this population and updated survival and validation results are presented. Methods: Baseline characteristics and outcomes on anti-VEGF-naïve metastatic RCC patients were collected from three US and four Canadian centers. Using a Cox proportional hazards model, 3 risk categories for predicting survival were identified on the basis of 6 pretreatment clinical features. Results: Six-hundred forty-five patients were included. The median (m) OS was 22 months (95% CI: 20.0–24.8) with a median follow-up of 25 months. Patients were treated with sunitinib (n = 396), sorafenib (n = 200) or bevacizumab (n = 49); 33% had prior immunotherapy. Four of the five PFs previously identified by MSKCC were independent predictors of short survival, including hemoglobin below the lower limit of normal (LLN) (p &lt; 0.0001), corrected calcium above the upper limit of normal (ULN) (p = 0.0006), Karnofsky performance status &lt;80% (p &lt; 0.0001) and time from initial diagnosis to initiation of therapy ULN (pULN (p = 0.012) were independent adverse PFs. Patients were assigned one point for each poor PF and were segregated into three risk categories: favorable-risk (0 PFs, n = 133) median OS (mOS) 37.0 months; intermediate-risk (1 - 2 PFs, n = 292) mOS 28.5 months; and poor-risk (3–6 PFs, n = 139) mOS 9.4 months (log rank p &lt; 0.0001). This model produced a c-index of 0.74 and the bootstrap procedure confirmed good internal validity. The discriminatory ability of the model and its parameter estimates were not affected after adjusting for prior use of immunotherapy or the type of anti-VEGF drug used. Conclusions: These data validate components of the MSKCC model with the addition of platelet and neutrophil counts. This model derived from a large population can be incorporated into patient care and clinical trials of VEGF-targeted agents. [Table: see text]
Expression of adhesion molecules in pagetoid reticulosis (Woringer-Kolopp disease)
Authors: P. DRILLENBURG, C.M. BRONKHORST, A.C. VAN DER WAL, L.A. NOORDUYN, R. HOEKZEMA, S.T. PALS
Journal: British Journal of Dermatology (1997)

Cell adhesion molecules play a critical role in lytnphocyte migration and homing. They convey tissue-specific homing properties to lymphocyte subsets and regulate the positioning of these subsets in the body. In a patient with pagetoid reticulosis. a rare form of cutaneous T-cell lymphoma characterized by extreme epitheliotropism. we examined the expression of adhesion molecules. The neoplastic T lymphocytes showed a strong expression of cutaneous lymphocyte antigen, a skinhoming receptor which interacts with E-selectin on skin endothelium. αEβ7, an adhesion molecule interacting with E-cadherin on epithelial cells, was also expressed on tumour cells. These findings suggest that adhesion molecules are responsible for the unque growth pattern in pagetoid reticulosis. and for the clinical behaviour of the disorder.
Breast-feeding
Authors: M. Pardoe
Journal: BMJ (1948)

<h3>ABSTRACT</h3> Classical CD14<sup>+</sup> monocytes are the predominant monocyte population in human blood. They are primarily engaged in host defense programs and secrete pro-inflammatory cytokines that orchestrate immune responses. While aberrant monocyte activity elicits cytokine storms, dysfunctional monocytes are associated with immunoparalysis, an equally life-threatening state of immunosuppression observed in severe sepsis, trauma, or respiratory viral infections. Hence, unraveling the mechanisms controlling monocyte functions is paramount in diverse clinical settings. Here, we reveal a critical dependency on platelets for the pro-inflammatory cytokine responses of human monocytes. We found that platelet removal from freshly isolated primary human monocytes causes monocyte immunoparalysis, characterized by transcriptional shut down of pro-inflammatory genes, and impaired cytokine secretion upon Toll-like and NOD-like receptor activation. Notably, anergic platelet-depleted monocytes can be reactivated upon their replenishment with autologous platelets. Moreover, monocytes from patients with immune thrombocytopenia display naturally impaired cytokine responses, which were also reversed by platelet supplementation. Mechanistically, we show that the trans-cellular propagation of platelet p38 MAPK signaling through platelet vesicles licences the full cytokine responses of human monocytes. Our findings delineate platelets as paramount regulators of monocyte innate immune functions. <h3>HIGHLIGHTS</h3> Platelets are essential to monocyte pro-inflammatory TLR and NLR responses. Platelet depletion causes a dynamic and reversible transcriptional reprogramming of human monocytes; Platelet supplementation reverts monocyte immunoparalysis in immune thrombocytopenia; Platelets supply p38 MAPK signalling that licenses full cytokine responses of human monocytes.
Modern Bullet Wounds and Modern Treatment, with Special Regard to Long Bones and Joints, Field Appliances and First Aid. Part of the Alexander Essay for 1903.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guarded Endorsement for Lyme Disease Vaccine
Authors: C. Marwick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Association between Fine Particles and Asthma Emergency Department Visits for Children in Seattle
Authors: Gary Norris, Sharon N. YoungPong, Jane Q. Koenig, Timothy V. Larson, Lianne Sheppard, James W. Stout
Journal: Environmental Health Perspectives (1999)

Asthma is the most common chronic illness of childhood and its prevalence is increasing, causing much concern for identification of risk factors such as air pollution. We previously conducted a study showing a relationship between asthma visits in all persons < 65 years of age to emergency departments (EDs) and air pollution in Seattle, Washington. In that study the most frequent zip codes of the visits were in the inner city. The Seattle-King County Department of Public Health (Seattle, WA) subsequently published a report which showed that the hospitalization rate for children in the inner city was over 600/100,000, whereas it was < 100/100,000 for children living in the suburbs. Therefore, we conducted the present study to evaluate whether asthma visits to hospital emergency departments in the inner city of Seattle were associated with outdoor air pollution levels. ED visits to six hospitals for asthma and daily air pollution data were obtained for 15 months during 1995 and 1996. The association between air pollution and childhood ED visits for asthma from the inner city area with high asthma hospitalization rates were compared with those from lower hospital utilization areas. Daily ED counts were regressed against fine particulate matter (PM), carbon monoxide (CO), sulfur dioxide, and nitrogen dioxide using a semiparametric Poisson regression model. Significant associations were found between ED visits for asthma in children and fine PM and CO. A change of 11 microg/m3 in fine PM was associated with a relative rate of 1.15 [95% confidence interval (CI), 1.08-1.23]. There was no stronger association between ED visits for asthma and air pollution in the higher hospital utilization area than in the lower utilization area. These findings were seen when estimated PM2.5 concentrations were below the newly adopted annual National Ambient Air Quality Standard of 15 microg/m3.
Effectiveness of antihistamines in the symptomatic management of the common cold
Authors: J. C. Howard
Journal: JAMA (1979)

A multicentric trial compared the effects of chlorpheniramine maleate with a placebo on the signs and symptoms of the common cold. Two hundred seventy-one patients were domiciled for 48 hours and evaluated during this period and for four days afterwards. Evaluations by both patients and physicians showed that chlorpheniramine maleate was superior to placebo in lessening the degree of symptoms of the common cold. Statistically significant differences were found both on the first day and as late as the seventh day. Significant differences and trends were shown in such measures as total objective score, physicians' evaluation, and patients' evaluation of symptoms. The overall incidence of side effects other than drowsiness did not differ between the treatment groups. (<i>JAMA</i>242:2414-2417, 1979)
Acid sensing in renal epithelial cells
Authors: S. L. Gluck
Journal: Journal of Clinical Investigation (2004)

The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney.
Association of moderate alcohol consumption and plasma concentration of endogenous tissue-type plasminogen activator
Authors: P. M. Ridker
Journal: JAMA (1994)

<h3>Objective.</h3> —To assess whether an association exists between moderate alcohol consumption and plasma concentration of endogenous tissue-type plasminogen activator (t-PA), a serine protease that plays a central role in the regulation of intravascular fibrinolysis. <h3>Design.</h3> —Survey of self-reported alcohol consumption and plasma fibrinolytic capacity, controlled for lipid and nonlipid cardiac risk factors. <h3>Setting.</h3> —Participants in the Physicians' Health Study. <h3>Participants.</h3> —A total of 631 apparently healthy male physicians aged 40 to 84 years with no history of myocardial infarction, stroke, or transient cerebral ischemia. <h3>Main Outcome Measure.</h3> —Plasma concentration of t-PA antigen. <h3>Results.</h3> —A direct association was found between alcohol consumption and plasma level of t-PA antigen, such that mean plasma levels of t-PA antigen for daily, weekly, monthly, and rare or never drinkers were 10.9,9.7,9.1, and 8.1 ng/mL, respectively (<i>P</i>trend=.0002). The relation between alcohol consumption and t-PA antigen level was not materially changed in analyses that adjusted for total cholesterol and high-density lipoprotein cholesterol or nonlipid cardiovascular risk factors including age, body mass index, parental history of coronary heart disease, exercise frequency, and systolic and diastolic blood pressure. <h3>Conclusions.</h3> —These data indicate a positive association between moderate alcohol intake and plasma level of endogenous t-PA antigen that is independent of high-density lipoprotein cholesterol. This finding supports the hypothesis that changes in fibrinolytic potential may be an important mechanism whereby moderate alcohol consumption decreases risk of heart disease. (<i>JAMA</i>. 1994;272:929-933)
Association News.
Authors: Henry E. Tuley
Journal: JAMA (1901)

<h3>The Doctors' Special to St. Paul.</h3> Louisville, Ky., March 15, 1901. <h3>To the Editor:</h3> —The nearness of the next meeting of theAssociationin St. Paul suggests the necessity of plans being laid for attendance by the profession of the country, and consequently the selection of a route. The many advantages of traveling in large numbers to these meetings can be vouched for by those who have been fortunate enough to so travel to several meetings in the past. As Louisville is one of the gateways for Chicago and St. Paul, arrangements have been made for special accommodations from this point, with special doctors' sleepers attached to the regular service of the Monon Route to Chicago and from that point by the Chicago &amp; Northwestern Railroad to St. Paul. Close connections will be made at Louisville with the Southern and the Louisville &amp; Nashville railways from points in the South,
Time to treatment influences the impact of ST segment resolution on one year prognosis: Insights from ASSENT-2 Yuling Fu, Shaun Goodman, Wei-Ching Chang, Padma Kaul, Frans Van de Werf, Christopher B. Granger, Paul W. Armstrong, for the ASSENT 2 Investigators. University of Alberta, Edmonton, AB, Canada
Journal: Journal of the American College of Cardiology (2001)
Combined Annual Scientific Sessions: Society for Clinical Trials and Eighth Annual Symposium for Coordinating Clinical Trials
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Combined Annual Scientific Sessions: Society for Clinical Trials and Eighth Annual Symposium for Coordinating Clinical Trials Get access JNCI: Journal of the National Cancer Institute, Volume 65, Issue 5, November 1980, Page 1198, https://doi.org/10.1093/jnci/65.5.1198 Published: 01 November 1980
JOINT TUBERCULOSIS.
Authors: DE FOREST WILLARD
Journal: JAMA (1901)

The discussion of tuberculosis of the hard and soft parts has been so general in the past years that it would hardly seem necessary at this date to emphasize the extent or the importance of this infection in the production of bone or joint disease, but the fact still remains that a large proportion of cases of joint tuberculosis are not recognized until the period of actual destruction has taken place. Tuberculosis of the joints, as of the lungs, requires for its arrest a diagnosis at the very beginning of the infection. At this time, while it is a purely local process, arrest and cure are perfectly feasible; in the later stages, destruction of bone or joint or limb or life is probable. It is of the utmost importance, therefore, that a recognition of the earliest signs should be urged upon the general practitioner, so that curative measures may be
Type E botulism from home-canned gefilte fish. Report of three cases
Authors: R. W. Armstrong
Journal: JAMA (1969)

Type E botulism occurred in three patients, one of whom died. The most prominent feature in all three cases was severe gastrointestinal symptoms (vomiting and abdominal discomfort without diarrhea), which diverted attention from the less prominent and more slowly developing neurological signs. Type E botulinus toxin was detected in the blood of the patient who died. The botulinus toxin was traced to home-prepared gefilte fish from which the three patients had eaten at a common meal. Lethal quantities of type E botulinus toxin were found in extracts of leftover gefilte fish, and<i>Clostridium botulinum</i>type E was recovered from cultures of the food. The incriminated food, which was eaten cold, had been prepared from fresh Great Lakes whitefish, cooked, and stored in a sealed jar in a household refrigerator for seven weeks before it was opened on the day of the meal.
High Prevalence of Mutators inEnterobacter cloacaeNosocomial Isolates and Their Association with Antimicrobial Resistance and Repetitive Detection
Authors: Aki Matsushima, Shunji Takakura, Naoko Fujihara, Takashi Saito, Yutaka Ito, Yoshitsugu Iinuma, Satoshi Ichiyama
Journal: Clinical Microbiology and Infection (2009)
NEWS NOTES FOR THE ANNALS
Journal: Annals of Internal Medicine (1956)

College News Notes1 May 1956NEWS NOTES FOR THE ANNALSAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-5-cxlv SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMembers and subscribers to the ANNALS OF INTERNAL MEDICINE are invited to send in any news items of interest in the field of internal medicine. Information concerning coming events, such as meetings, postgraduate courses, scholarships, honors, awards, etc., or personal items about members of the College should be submitted at least two to three months in advance of publication. News items close on the 10th of the second month preceding publication. Please make such notes in all detail, names, dates and places. Send them to the News Editor, American College of Physicians, 4200 Pine St., Philadelphia 4, Pa.NEW LIFE This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1956Volume 44, Issue 5Page: cxlv-clxii Issue Published: 1 May 1956 PDF downloadLoading ...
Fullness of Life Restored
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUBDURAL HEMORRHAGES
Authors: TIMOTHY LEARY
Journal: JAMA (1934)

Mystery has always shrouded the supposedly rare condition to which Virchow gave the name of pachymeningitis hemorrhagica interna chronica. Neither the title nor Virchow's study of the subject tended to abate the mystery. It is my purpose in this paper (1) to endeavor to dispel this mystery, (2) to demonstrate that the condition is not rare, (3) to call attention to its operative curability in many cases and (4) to indicate its possible medicolegal relations. The Massachusetts medical examiner law gives the medical examiner exclusive opportunity to investigate deaths by violence. This exclusive opportunity entails a stewardship with a responsibility for the proper use of the material that comes into his hands. One of the implied obligations of the medical examiner is to aid or if possible to stimulate medical progress in dealing with the results of traumatism. The appalling death rate from automobile and other traumatic hazards approximates wartime
Hospitals, Chicago
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RURAL HEALTH CENTERS AS AIDS TO GENERAL PRACTITIONERS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal