tbuckley/cabot-search huggingface dataset:
The Relation of Atmospheric Humidity to Health
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Different origin from elevated hepatocyte- and vascular endothelial growth factor serum levels in patients after myocardial infarction. Role of leukocyte activation Achim Gutersohn, Jr., Ahmet H. Elmaagacli, Thomas Budde, Jochen Buchholz, Ulrich W. Sch�fer, Raimund Erbel. University of Essen, Essen, Germany. ALfried Krupp Hospital, Essen
Journal: Journal of the American College of Cardiology (2001)
Dying and dementia
Authors: J. Lynn
Journal: JAMA (1986)

Volicer et al,<sup>1</sup>in this issue ofThe Journal, report a remarkably practical, commonsense experience in limiting potentially life-extending treatments for persons with advanced senile dementia of the Alzheimer's type. Debate about forgoing life-extending treatment has recently been impaired by the irrational pretense, especially evident with "Baby Doe,"<sup>2</sup>that severe and permanent mental disability should not have a bearing on medical treatment choices. If future policy evidences more wisdom about this issue, we shall look back on this era as a temporary aberration during which it was easier to get resuscitation or extensive surgery for an older person than to provide a balanced meal or a pair of eyeglasses. On the way to that better future, caution and thoughtful reflection are essential. Although Volicer and colleagues have made significant strides, their path includes some pitfalls. For example, they present the central issue as one of refusing certain modes
Association News.
Authors: Charles A. L. Reed
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Der Weg zur rationellen Therapie.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STAT3 Controls the Neutrophil Migratory Response to CXCR2 Ligands by Direct Activation of G-CSF-Responsive CXCR2 Expression and Via Modulation of CXCR2 Signal Transduction .
Authors: Hoainam Nguyen-Jackson, Athanasia Panopoulos, Huiyuan Zhang, Haiyan S. Li, Stephanie Watowich
Journal: Blood (2009)
Union Médicale du Canada, Montreal
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Informed Consent
Authors: Edward B. Feehan
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Laforet (235:1579, 1976) wrote interestingly and at length about the concept of informed consent. He implied that it is a concept that is ambiguous to those involved in patient care at the physician-patient level and also that it is a redundant term. Probably, the concept of informed consent is an evolving concept and, as such, may well be ambiguous to many. I do not think it is quite all that ambiguous to everyone involved at the physician-patient level, as implied. I think I have a fairly good grasp of the concept myself, and I am just an ordinary worker in a semirural pediatric practice. Laforet asks: "Can two people think together if either is<i>uninformed</i>?" The answer to this is obviously "yes." In<i>Webster's New Twentieth Century Dictionary</i>, ed 2, "informed" is defined as an adjective: "having much information, knowledge, or education." "Consent," as a noun, is
The Role of Calcium Ions in Toxic Cell Injury
Authors: John L. Farber
Journal: Environmental Health Perspectives (1990)

Calcium ions have been increasingly implicated as a mediator of the mechanisms generating lethal cell injury under a variety of pathologic circumstances. An overview of the various roles suggested for such alterations in cellular calcium homeostasis is presented. The central role of plasma membrane damage in the genesis of irreversible cell injury is used to divide the postulated roles for calcium ions into two major mechanisms. On the one hand, calcium ions have been proposed as mediators of the functional consequences of plasma membrane injury. An influx of extracellular calcium ions across a damaged permeability barrier and down a steep concentration gradient may convert potentially reversible injury into irreversible injury. On the other hand, alterations in intracellular calcium homeostasis are postulated to participate in the mechanisms generating potentially lethal plasma membrane injury. The release of calcium stores sequestered within intracellular organelles raises the cytosolic concentration of free calcium, a process that may activate, in turn, a number of membrane-disruptive processes. The data supporting these two distinct actions of calcium are reviewed and discussed.
Normal Sweat Chloride Values Do Not Exclude the Diagnosis of Cystic Fibrosis
Authors: Barbara Stewart, Joseph Zabner, Anthony P. Shuber, Michael J. Welsh, Paul B. McCray
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Since its introduction in 1959, the sweat test has remained the “gold standard” diagnostic test for cystic fibrosis (CF). It is apparent that CF encompasses a wide spectrum of disease, from meconium ileus and severe respiratory compromise in infants to the presentation of mild pulmonary symptoms and no evidence of gastrointestinal disease in adults. In patients with lung disease that might otherwise be consistent with CF, normal sweat chloride (CI−) values have tended to exclude the diagnosis. In this report we describe two patients from two families with the compound heterozygotic CF mutations ΔF508/3849 + 10 kb C→T. These patients had mild manifestations of disease, including clinical pancreatic sufficiency (normal growth without pancreatic enzyme supplementation) and absence of azoospermia. Sweat CI− values were in the normal range. However, both patients developed bronchiectasis, progressive obstructive lung disease, and colonization with Pseudomonas. The diagnosis of CF was made using nasal transepithelial voltage measurements and genotyping. These cases emphasize the need to maintain a high index of suspicion of CF in atypical cases, and to pursue alternative diagnostic tests to confirm a diagnosis of CF suspected on clinical grounds, despite normal sweat test results.
F2-isoprostanes mediate high glucose-induced TGF-beta synthesis and glomerular proteinuria in experimental type I diabetes
Authors: Angel Montero, Karen A. Munger, Rizwan Z. Khan, Jose M. Valdivielso, Jason D. Morrow, Antonio Guasch, Fuad N. Ziyadeh, Kamal F. Badr
Journal: Kidney International (2000)
Epidemiological Psychiatry
Authors: John J. Schwab
Journal: JAMA (1974)

Epidemiology has made substantive contributions that led to the prevention of many infectious and deficiency diseases. Epidemiologists are now investigating the chronic diseases, such as coronary heart disease, apparently due to multiple factors, and the mental disorders, in large part a by-product of man's social existence. Epidemiological psychiatry is in an embryonic stage; as a field, it is exasperatingly nebulous yet, because of the sociocultural implications, the findings hold great interest for the public as well as for professionals. This short lucid volume describes some of the major investigative work and points out the problems confronting researchers. The most important and perhaps the most baffling is the long-standing difficulty with conceptualizing and defining mental illness. For the most part, mental illness is a culturally defined condition; the definition varies from culture to culture, changes over time, and even contracts and expands in a given society within a few decades, especially
Researchers express heartfelt wishes for success of molecular biology techniques in cardiac care
Authors: M. F. Goldsmith
Journal: JAMA (1991)

MILKING SHEEP to obtain the material for lifesaving drugs may come to seem no stranger than keeping flocks to provide the basis for Roquefort cheese, if experimental molecular biology procedures already under way are adopted someday. At the 63rd Scientific Sessions of the American Heart Association, held in Dallas, Tex, investigators discussed the use of recombinant DNA technology to combat cardiac (and other) disorders more directly than was ever possible before. "At the present time," says Robert Roberts, MD, chief of cardiology, Baylor College of Medicine, Houston, Tex, "the Food and Drug Administration has approved only about 10 drugs that are made by recombinant DNA. The agency estimates that, by the year 2000, more than 50% of all approved drugs will be made by this method." (A spokesman for the Pharmaceutical Manufacturers Association estimates that there are currently approximately 3500 approved "chemical entities [drugs]." He said 104 recombinant drugs await
X-Irradiation-Induced Mitotic Abnormalities in Mouse Liver Regenerating after Carbon Tetrachloride Injury. I. Total-Body Irradiation&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Mary Day Albert
Journal: JNCI Journal of the National Cancer Institute (1958)

X-Irradiation-Induced Mitotic Abnormalities in Mouse Liver Regenerating after Carbon Tetrachloride Injury. I. Total-Body Irradiation Get access Mary Day Albert Mary Day Albert Department of Biology, Brown University, Providence, Rhode Island Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 2, February 1958, Pages 309–319, https://doi.org/10.1093/jnci/20.2.309 Published: 01 February 1958 Article history Received: 24 June 1957 Published: 01 February 1958
Improved Survival Seen for Some with Pancreatic Cancer
Journal: Cancer Discovery (2018)

Abstract In two pancreatic cancer trials—the randomized phase III PRODIGE 24/CCTG PA.6 and PREOPANC-1 trials—researchers found that experimental drug regimens for patients with resectable adenocarcinomas increased overall survival or showed a trend in that direction. The findings could prompt changes in clinical practice for these patients.
Stroke in <i>Circulation</i> and the <i>Circulation</i> Subspecialty Journals
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the articles related to stroke that were published in Circulation and the Circulation subspecialty journals in 2010 and 2011.
Forensic Medicine: A Guide to Principles
Authors: Milton G. Bohrod
Journal: JAMA (1984)

This second edition appears eight years after the first and retains all its virtues and faults. Although it has been touched up, the changes and the additions have been moderate. No one who owns a first edition will need a new one. As the authors say in the preface, they did "not set out to compile a forensic catalogue." This is not necessarily a defect in a book. More important is the imbalance noted in the earlier volume. Space is allotted almost entirely according to the authors' interests, and important subjects are skimmed over or neglected, especially toxicology, which they regard as a "non-subject." Yet they devote more than the usual space to arsenic poisoning. The book is not the best choice for the young student. Experienced forensic pathologists will, on the other hand, find many interesting and important discussions. They may not always agree, but they cannot fail to
A NEW RADIUM DANGER.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unreviewed Reports
Journal: BMJ (1986)

Unreviewed ReportsUnilateral gynaecomastia and nifedipine Three white men aged 57, 68, and 71 presented with unilateral gynaecomastia which had developed gradually four, six, and 26 weeks after they started nifedipine.None were taking other drugs recognized to be associated with gynaecomastia.' Daily dosage of nifedipine ranged from 10 mg to 80 mg, and in the one case in which the drug had been stopped for two months the gynaecomastia was regressing.Although the Committee on Safety of Medicines and manufacturers are aware of 10 previous cases, this association does not appear to have been published.'-C
Results of a phase II multicenter study of neoadjuvant S-1 and irinotecan in patients with locally advanced gastric cancer.
Authors: M. Terashima, Z. Saze, R. Hosotani, M. Takahashi, A. Takagane, O. Hachiya, K. Koeda, S. Matsui, W. Ohashi, M. Gotoh
Journal: Journal of Clinical Oncology (2010)

4122 Background: Combination chemotherapy involving S-1 and irinotecan (IRIS) has failed to demonstrate a survival benefit over S-1 alone in metastatic gastric cancer. However, the tumor response rate was significantly higher with IRIS. Therefore, we evaluated the effect of IRIS as neoadjuvant chemotherapy for locally advanced gastric cancer. An exploratory study of gene expression analysisfor establishing predictive markers was also performed. Methods: Patients with locally advanced gastric adenocarcinoma, T3-4, N0-3, M0, for whom curative surgery was planned after neoadjuvant chemotherapy, PS 0-1, with adequate organ function were enrolled in this study. Patients received irinotecan 80 mg/m2 on days 1 and 15 and oral S-1 80 mg/m2/day on days 1 to 21. Treatment was repeated every 28 days for 2 courses. Patients then underwent gastrectomy with lymphadenectomy. After surgery, patients resumed treatment with S-1 alone for 1 year. Pretreatment biopsy and surgically resected specimens were subjected to gene expression analysis using a Taqman low density array (93 genes). Results: Of the 39 patients enrolled, 38 were eligible. Two cycles of chemotherapy were completed in 35 patients, and surgery was performed in 30 patients. Of 27 RECIST-evaluable patients, 16 (59%) had a partial response and 9 (33%) had stable disease. Pathological response was observed in 13 of 30 patients (43%); 2 patients had pathological CR. Curative resection was possible in 18 of 29 patients (62%). Major grade 3 toxicities were neutropenia in 3, anorexia in 2, nausea in 1, diarrhea in 1, and fatigue in 1. Postoperative complications were observed in 11 (36.3%) patients. There were no treatment-related deaths. High expressions of UMPS, SLC29A2, UNG, and TDP1, and low expressions of CDKN1A were significantly correlated with tumor response. Conclusions: These results show that neoadjuvant S-1 and irinotecan combination chemotherapy was active and feasible for treating locally advanced gastric cancer. A further large scale trial is warranted. No significant financial relationships to disclose.
From the Centers for Disease Control. State-based chronic disease control: the Rocky Mountain tobacco-free challenge
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic Effect of Cigarette Smoking on Pulmonary Ventilation
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal