tbuckley/cabot-search huggingface dataset:
Abstract 3525: The effects of Berberis vulgaris on bacterial inhibition and the p53 gene in cancerous Caenorhabditis elegans
Authors: Jesal P. Bhatt
Journal: Cancer Research (2016)

Abstract Recently, there has been an interest in the use of natural products to inhibit bacterial growth rather than manufactured antibiotics due to the problem of bacterial resistance. This study aims at finding the most effective natural antibacterial remedy. The disk diffusion method was used to compare the antibacterial properties of manuka honey, barberry, aloe vera, and colloidal silver. After a 48-hour incubation period, the zone of inhibition was measured for the following bacteria: Bacillus megaterium, Serratia marcescens, Pseudomonas fluorescens, Rhodospirillum rubrum, and Escherichia coli. Barberry was the most efficient natural product (p = 0.02). Further tests were performed to determine whether barberry contained strong anticancer properties. Barberry was tested on Caenorhabditis elegans (C.elegans), strain JR1279, exposed to ultraviolet-C radiation and the population was counted daily. Prior to this experiment, barberry had never before been tested on a model organism. The purpose of this experiment would determine if barberry could increase the lifespan of the C.elegans by the addition of this reagent. It was shown that the C.elegans exposed to barberry had a longer lifespan than those that were not exposed to barberry (p = 0.01), indicating that barberry could be a potential anticancer supplement. Citation Format: Jesal P. Bhatt. The effects of Berberis vulgaris on bacterial inhibition and the p53 gene in cancerous Caenorhabditis elegans. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3525.
Reply
Authors: Jennifer C. Lai, Kenneth E. Covinsky, Jennifer L. Dodge, W. John Boscardin, Dorry L. Segev, John P. Roberts, Sandy Feng
Journal: Hepatology (2018)

Potential conflict of interest: Dorry L. Segev is on the speakers' bureau for Sanofi and Novartis. Sandy Feng consults for Juno; has received grants from Novartis and Quark; and owns stock in Abbott, Amgen, Charles River Labs, Eli Lilly, Express Scripts, GlaxoSmithKline, Hospira, Johnson & Johnson, Medco, Merck, Pfizer, and Stryker. We thank Drs. Fan and Zhu for their questions in response to our recent article "Development of a Novel Frailty Index to Predict Mortality in Patients with End‐Stage Liver Disease."1 Drs. Fan and Zhu have importantly noted that we only assessed frailty in waitlist candidates seen as outpatients. Our intention in restricting measurements to the outpatient setting was to capture patients' underlying physiologic reserve that would increase their vulnerability to acute stressors while on the waitlist above and beyond their liver disease severity alone. In the inpatient setting, on the other hand, performance‐based frailty instruments capture the combination of underlying (chronic) physiologic reserve in addition to the effects of the acute illness, the latter of which may not affect longer‐term outcomes after the acute stressor has resolved. We agree that there is a need for assessment of physiologic reserve in the inpatient setting, but our Liver Frailty Index was not intended for this purpose. As for the concern regarding our validation methodology, we used a parsimonious model and internally bootstrapped the c‐statistic, a method that has been shown to be equivalent to validation using a split‐sample cohort.2 Although we agree that external validation remains the gold standard to assess prognostic validity of this index, this requires a large cohort of liver transplantation candidates at another institution with measurement of the Liver Frailty Index with long enough follow‐up on the waitlist to capture a sufficient number of events. Given that the Liver Frailty Index consists of components that have not been previously measured at other institutions, such data were not readily available (although we are currently working to establish these cohorts). Moving beyond statistical assessments of prognostic value, however, we should emphasize that we developed the Liver Frailty Index to fill a gap in our clinical practice: the lack of an objective metric of physical frailty. Transplant clinicians are accustomed to incorporating objective data into assessments of their patients' health; they may use a myocardial perfusion study to assess cardiac health or pulmonary function tests to assess respiratory health rather than rely solely on the presence of angina or dyspnea, or their auscultative abilities. The Liver Frailty Index is yet another objective metric that we can use to anchor our assessments of patients' health—as well as fitness for transplantation—with data that accurately reflect their true physiologic reserve.3
The Texas Courier-Record of Medicine.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disappearance of Micro-Emboli Transfused into Patients During Cardiopulmonary Bypass
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Information resources and latest news about Ebola virus disease available from ECDC
Authors: None Eurosurveillance editorial team
Journal: Eurosurveillance (2014)

Preview this article: Information resources and latest news about Ebola virus disease available from ECDC, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/19/31/art20871-en-1.gif
EDITORIAL
Journal: British Journal of Sports Medicine (1983)

In this early Spring, we can look towards the finish of the Winter games, and the stresses that promotion or relegation bring, together with intense competition for cups and championships all falling on players tired after a long season, losing basic fitness, and therefore more susceptible than ever to overuse and acute extrinsic injuries.At long last the medical profession seems to be waking up to some of the more serious sequelae of sport, and several articles have appeared in various journals pointing out the increased incidence of major trauma sustained by collapsing rubgy scrums, and another campaign for the abolition of professional boxing.Spring also heralds the beginning of the bathing, boating, diving and drowning season, so it is not inappropriate that we begin this issue of the journal with a leading article by Mark Harries, Medical Officer to the Surf Life Saving Asso- ciation and to the British Surfing Association.Although surf off British coasts is not as dramatic as it is off California, Australia or Hawaii, it is still enough to provide an exciting sport, but because of the lower temperatures, hazards of hypothermia are higher than in sub-tropical environments.A report of a near-fatality in a sports diver by the two Senior Registrars of the Leicester Royal Infirmary Accident and Emergency Department follows, and again emphasises the need to be prepared for immediate and adequate decompression at all sites where diving takes place.
Getting Closer to a Fully Correctable and Connected Research Literature
Journal: PLoS Medicine (2013)

Any claim that science is wholly true and definitive (as the media would sometimes have us believe) is nonsense.Current conditions and incentives exist for researchers to engage in poor behavior to advance their careers, establish noteworthy results, gain tenure and eminence, and indeed basically to ''publish or perish.''At one end of the spectrum is research misconduct, to which there are generally three reactions: deny its existence, chalk it up to a few ''bad apples,'' or accept that it is inevitable and in fact pervasive.This latter approach, which we support, requires that processes are put in place to identify and manage misconduct if prevention is not possible.But there is a bigger challenge: many scientific findings, once thought to be certain, will ultimately be shown to be uncertain by new techniques, a change in thinking, improved data, or the result of a honest error.Unfortunately, changes in the published literature-whatever their origin-simply don't have an adequate paper or electronic trail.Is it time to rethink the correction of the literature?These topics are at the forefront of recent discussions.On 22 March 2013 the Committee on Publication Ethics (COPE, of which VB is chair), the advisory group for editors, held its European Seminar on the topic of ''Publication ethics from student to professional'' [1].The Evidence Live meeting, running between 25 and 28 March [2], includes keynote speeches on research misconduct in the pharmaceutical and medical devices industries and on scientific integrity in scholarly journals.
Outbreak of Influenza-Like Illness in a Tour Group—Alaska
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The effects of psychosocial services in substance abuse treatment
Authors: A. T. McLellan
Journal: JAMA (1993)

<h3>Objective.</h3> —To examine whether the addition of counseling, medical care, and psychosocial services improves the efficacy of methadone hydrochloride therapy in the rehabilitation of opiate-dependent patients. <h3>Design.</h3> —Random assignment to one of three treatment groups for a 6-month clinical trial: (1) minimum methadone services (MMS)—methadone alone (a minimum of 60 mg/d) with no other services; (2) standard methadone services (SMS) —same dose of methadone plus counseling; or (3) enhanced methadone services (EMS)—same dose of methadone plus counseling and on-site medical/psychiatric, employment, and family therapy. <h3>Setting.</h3> —The methadone maintenance program of the Philadelphia (Pa) Veterans Affairs Medical Center. <h3>Subjects.</h3> —Ninety-two male intravenous opiate users in methadone maintenance treatment. <h3>Results.</h3> —While methadone treatment alone (MMS) was associated with reductions in opiate use, 69% of these subjects had to be "protectively transferred" from the trial because of unremitting use of opiates or cocaine, or medical/ psychiatric emergencies. This was significantly different from the 41% of SMS subjects and 19% of EMS subjects who met the criteria. End-of-treatment data (at 24 weeks) showed minimal improvements among the 10 MMS patients who completed the trial. The SMS group showed significantly more and larger improvements than did the MMS group; and the EMS group showed significantly better outcomes than did the SMS group. Minimum methadone services subjects who had been "protectively transferred" to standard care showed significant reductions in opiate and cocaine use within 4 weeks. <h3>Conclusions.</h3> —Methadone alone (even in substantial doses) may only be effective for a minority of eligible patients. The addition of basic counseling was associated with major increases in efficacy; and the addition of on-site professional services was even more effective. (<i>JAMA</i>. 1993;269:1953-1959)
Kidney Retrieval
Authors: Rudolph H. de Jong
Journal: JAMA (1976)

The short supply of cadaveric kidneys has been a persistent bottleneck in providing the benefits of renal allotransplantation to patients with end-stage renal disease. An article in the August issue of<i>Archives of Surgery</i>(111:871-873, 1976) describes how a regionally organized retrieval effort can triple the yield of cadaveric kidneys for use in a transplant center over the number previously obtained from a large metropolitan area (Kansas City). Local hospital personnel were trained for a week in the basics of kidney retrieval, preservation, and preparation for shipping, while local physicians attended orientation programs and a workshop. Public education efforts rounded out the program. Eighteen months<i>before</i>the program was started, 65 kidneys were obtained from 35 donors. In a corresponding six-month period 18 months<i>after</i>the program was started, 160 kidneys were harvested from 83 donors. Particularly heartening was the gain in kidneys used for transplantation: from 65% before the
Some Reasons for "Hard Times" Among Physicians.
Authors: None L. S. B.
Journal: JAMA (1897)

Chicago, Sept. 16, 1897. <h3>To the Editor:</h3> —I am very sorry that I can not comply with your letter at the present moment, but will try my best to make it good at my very earliest convenience. From five medical journals, I limited myself to two, including yourJournal, so hard is the time on the general practitioner of Chicago. If all the hospitals and dispensaries of Chicago be closed up at once, and only those admitted who possess a certificate of being poor and entitled to free treatment; if no regular physician would accept a case for treatment until the first physician was paid; and if all the medical colleges would, besides their business views, try at the same time to elevate the medical standard, there would be no difficulty for any practicing physician to pay his subscription fees promptly for any number of medical journals. Thinking that these
The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis
Authors: J.P. Thyssen, A.-S. Halling-Overgaard, Y.M.F. Andersen, G. Gislason, L. Skov, A. Egeberg
Journal: British Journal of Dermatology (2018)

Atopic dermatitis (AD) is a common type of eczema in children, which can carry on into adulthood in some people. It has been linked to other diseases (known as ‘comorbidities’) but results from studies exploring if there is a link with type 2 diabetes, and cardiovascular disease (CVD – a group of diseases/conditions including stroke, hypertension, myocardial infarction, angina, coronary artery disease and heart failure), have been conflicting. This study, from Denmark, analysed the 16 most relevant studies comparing the risk of CVD and diabetes for adult patients with and without AD. No association was found between AD and type 2 diabetes, hypertension, stroke or myocardial infarction, but an association was found with angina pectoris, although this was based on only four studies. The authors conclude that while, in some populations, there are higher rates of some of the factors that put people at higher risk of CVD (such as smoking and obesity), it is unlikely that AD is, in itself, a risk factor for CVD.
ON CHANGING TERMINOLOGIC HORSES
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SUBSTERNAL GOITER
Authors: FRANK H. LAHEY
Journal: JAMA (1926)

Substernal goiter is a condition that is readily overlooked and often not recognized until a distinctly serious situation has arisen. It is not discussed extensively in the literature, and except in clinics where thyroids are dealt with in numbers it is often not looked for except when producing unmistakable pressure symptoms. From our experience with this condition, it is one that readily lends itself to prevention, by occasional examinations to determine the progressive descent of a goiter and by early removal of those goiters tending to descend into the thorax. I have repeatedly stated and written and I urge again that progressive descent of a goiter or the location of adenomas or cysts of the thyroid where they may, or tend to, enter the mediastinum should be an outstanding indication for their surgical removal. Goiters that have entered the mediastinum and have deviated and flattened the trachea have done so,
Fast Acting Applanation Tonometers I
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA-RPS Instrumental in Achieving New Maternity Leave Policy
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Bacterial Endocarditis
Authors: Maxwell Finland
Journal: New England Journal of Medicine (1954)

ONE of the great triumphs of this era of chemotherapy and antibiotics has been achieved in the treatment of bacterial endocarditis. This disease, which before the introduction of the sulfonamides was almost universally fatal, affords an undisputed demonstration of the life-saving properties of the antibacterial agents, penicillin standing out as by far the most impressive of the agents thus far available. Many articles in the medical literature attest to the limited value of sulfonamides and to the striking clinical effects and reduction in mortality attributable to penicillin in the treatment of large numbers of cases.It is not the purpose . . .