tbuckley/cabot-search huggingface dataset:
Carpal tunnel syndrome. Importance of sensory nerve conduction studies in diagnosis
Authors: D. E. Hoffman
Journal: JAMA (1975)

CARPAL tunnel syndrome (median neuropathy at the wrist) is the commonest type of peripheral nerve entrapment syndrome in the upper limb. Electrophysiologic studies have been employed in the diagnosis of this syndrome for almost two decades. Still, however, a large number of these conditions will go undiagnosed unless the physician is aware of the importance of obtaining sensory nerve conduction determinations in suspected individuals. The following case report exemplifies this point. <h3>Report of a Case</h3> A 33-year-old right-handed physiotherapist was examined at University Hospitals because of a three-year complaint of episodic paresthesias and numbness in her right hand, extending to the shoulder. Symptoms were particularly bothersome at night, frequently awakening her; for the last three months, she had been unable to sleep through a single night. For the past month, she had mild tingling in her left hand and forearm. She denied neck or upper extremity injury. She had not
CAROTID SINUS SYNDROME
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Papanicolaou Testing Following Hysterectomy
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intradural Spinal Tuberculoma Presenting with Genitourinary Symptoms
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Missing Potential Conflict of Interest
Authors: Sheri Madigan, Joris Van Ouytsel, Jeff Temple
Journal: JAMA Pediatrics (2018)

without consent).Our meta-analysis of 5 studies focusing on perpetration of nonconsensual sexting and 4 studies on the victimization of nonconsensual sexting did not support these expectations.We also did not find any significant sex differences in the rate of consensual sending or receiving of sexts.On closer examination of the 5 studies that did report on the perpetration of nonconsensual sexting (see studies listed with FW-P under column "sexting type" in Table 1 ), 2 studies found no significant differences between girls and boys, 1 study found a statistically significant difference, with boys reporting a higher prevalence, and 2 studies that stratified prevalence across sex by race/ethnicity and country of origin found inconsistent sex differences across these stratification methods.Similarly, in the studies that examined victimization of nonconsensual sexting (see studies listed with FW-V in Table 1 ), 1 study found that girls in grades 10 to 11 (but not those in grades 6-7) were more likely than their male counterparts to have had sexts distributed, another found that only 1 of 5 countries examined had significant sex differences, and 2 studies did not provide a breakdown by sex.Thus, to answer the question, what we really know about sex differences in nonconsensual sexting is that it varies considerably from 1 study to the next, and when examined metaanalytically, no significant sex differences emerge.This conclusion applies to nonconsensual as well as consensual sexting.As noted in our article, 1 the sample sizes for the metaanalyses on nonconsensual sexting were small (perpetrator n = 5 and receipient n = 4).Thus, conclusions about the role of sex differences in nonconsensual sexting based on our metaanalysis are arguably tentative.As aptly noted by Reed et al, variations in study findings can occur because of differences across studies in how sexting is measured.Thus, we echo their comment as well those from others 2 that there is a need for more data and clearer measurement of sexting behaviors in future research.We look forward to meta-analyzing these data when they become available so that we can draw firm conclusions regarding sex differences pertaining to the nonconsensual forwarding of sexts.
Thirty-Eight Cases of the Guillain-Barré Syndrome: An Immunological Study
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase Ib study of eribulin (ERB) and cyclophosphamide (CTX) in metastatic breast cancer (MBC).
Authors: Thach-Giao Truong, Michael Pelayo, Jennifer A. Grabowsky, Michelle E. Melisko, Mark Jesus Mendoza Magbanua, Mark M. Moasser, Anne Reinert, Jimmy Hwang, John W. Park, Pamela N. Munster, Hope S. Rugo
Journal: Journal of Clinical Oncology (2013)

153 Background: ERB is a non-taxane microtubule inhibitor approved for the treatment (Tx) of taxane (TAX) and anthracycline-treated MBC based on improved OS compared to treatment of physician choice. In the adjuvant setting, docetaxel/CTX (TC) was superior to doxorubicin/CTX for DFS and OS. ERB is active in TAX-resistant disease with a low rate of peripheral neuropathy (PN); its primary dose-limiting toxicity (DLT) is bone marrow suppression. We hypothesized that the combination of ERB and CTX would be well tolerated and active in patients with TAX-resistant disease, with potential applicability to the adjuvant setting. Methods: We designed a 3+3 phase Ib study of ERB, administered in 2 escalating doses on day 1 and 8, with CTX 600 mg/m 2 day 1 every 21 days. Eligibility included PN ≤ grade 1. Correlative studies to identify predictors of response and toxicity included whole blood for SNPs, GWAS, circulating tumor cells (CTC), and archived tumor RNA/protein expression analysis. Toxicity assessment included QoL and evaluation of PN. Results: 6 patients (pts) with MBC, median age 50 (47-63), were enrolled. All pts had prior TAX exposure and 4 pts had baseline grade 1 PN. Tumor characteristics included hormone receptor + (5 pts), HER2+ (2 pts), and triple-negative (1 pt). Median number of prior Tx for MBC was 5 (1-8). No DLTs were observed; the RP2D is eribulin 1.4 mg/m2 on D1 and D8 with CTX D1 600mg/m2. Neutropenia was the only G3/G4 non-DLT observed at this dose, requiring GCSF support in cycle 1 in 2 of 3 pts. All grade toxicities included neutropenia (50%), thrombocytopenia, fatigue, nausea, PN, rash, mucositis, alopecia (33% each), and elevated liver enzymes (17%). Pts received a median of 5.5 cycles (range 3-13), with 3 pts still on Tx. Responses included 2PRs (33%) and 4 SD (67%). 2 pts stopped study Tx for QoL and continued ERB alone. Only 2 pts met threshold of &gt;5CTC/7.5ml at baseline; these had a mean decrease of 90.5% at the start of cycle 2. Conclusions: ERB and CTX is a well-tolerated regimen with promising activity in MBC, with the primary toxicity being neutropenia requiring growth factor support. A phase II study in MBC is underway. Additional correlative studies are ongoing, including molecular analyses of CTC. Clinical trial information: NCT01554371.
Hemorrhagic diathesis caused by drinking an herbal tea
Authors: R. P. Hogan
Journal: JAMA (1983)

"NATURAL" foods and herbal medicines have gained substantial popularity in the United States during the past two decades. These products often are assumed to be free of toxic side effects and are used in an effort to improve general health and well-being. This report describes a young woman in whom abnormal clotting function and mild clinical bleeding developed as a result of ingestion of an herbal tonic. <h3>Report of a Case</h3> A 25-year-old woman consulted her gynecologist because of menometrorrhagia. A small mass was palpated on pelvic examination, and the patient was admitted to the hospital for laparoscopy. A small amount of endometriosis was found, and the mass effect was thought to result from an unusually placed ovary. She was discharged from the hospital but continued to have abnormal menstrual bleeding. Her condition was reevaluated three weeks later, and she was found to have a prothrombin time of 53.4 s
Group A streptococci, mycoplasmas, and viruses associated with acute pharyngitis
Authors: W. P. Glezen
Journal: JAMA (1967)

Methods for identification of bacteria, viruses, and mycoplasmas were used to study pharyngitis in patients from a pediatric practice. Etiologic agents were recovered from 50% of 715 cultures from patients with pharyngitis and from 22% of 206 cultures from asymptomatic household contracts. Pharyngitis was diagnosed most often in children ages 6 through 8 years, and over one half of these illnesses were associated with group A streptococcus infections. Viruses were the most important cause of pharyngitis in infants, and Mycoplasma pneumoniae was associated with pharyngitis in early adolescence. Disease produced by viruses or M pneumoniae could not be distinguished from classical streptococcal pharyngitis. Mycoplasma hominis, which has produced exudative pharyngitis in adult volunteers, was not recovered from persons in this investigation; however, in other studies performed concurrently, M hominis was isolated from 0.5% of subjects including three adults with pharyngitis.
Melanin Pigmentation
Authors: Thomas B. Fitzpatrick, Makoto Seiji, A. David McGugan
Journal: New England Journal of Medicine (1961)

Genetic or Nevoid — Increased PigmentationFrecklesA freckle (ephelis) is a brown, circumscribed macule scattered irregularly on areas of skin exposed to sunlight. The term freckle is probably derived from the Old Norse, freknur. Chaucer used the term, "A few freckles in his face y-spreynd." Ephelis (or ephelides) is derived from the Greek, epi, upon, and helios, sun.Freckles are ordinarily quite distinctive in appearance and localization. Their differentiation from other pigmented macules, particularly lentigines, may be difficult or impossible without a biopsy. Freckles and lentigines have been confused in the literature. Brown68 has summarized some of the . . .
Increasing rates of depression
Authors: Rafiq Waziri
Journal: JAMA (1989)

<h3>To the Editor. —</h3> It would have been appropriate if Drs Klerman and Weissman<sup>1</sup>had ended the title of their article "Increasing Rates of Depression" with a large question mark. They have presented data from their own work with colleagues or other researchers suggesting that the rates of depression, especially in the younger age groups, are increasing. Some of this work is on populations and some on selected patients and their first-degree relatives. Unlike studies in medical epidemiology, where diagnoses are made with standard laboratory tests or instruments with known sensitivities and specificities, psychiatric studies use self-reports, complaints, and symptoms as the bases for recording psychopathology. The specificity of these techniques is unknown or low. These techniques have introduced so much elasticity in the concept of depression that stuporous or severely melancholic patients as well as those complaining from unhappiness owing to adverse conditions or character defects are all
Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
Authors: Norihito Uemura, Hisashi Yagi, Maiko T. Uemura, Yusuke Hatanaka, Hodaka Yamakado, Ryosuke Takahashi
Journal: Molecular Neurodegeneration (2019)

The original article [1] mistakenly omitted essential information regarding Fig. 1c; thus, the authors would like to note that Fig. 1c describes transmission electron microscopy of α-Syn PFFs before sonication.
Nutrition Almanac
Authors: Charles B. Clayman
Journal: JAMA (1979)

This paperback almanac is suitable for the public. It provides in simple terms and phrases a full discussion of the nutrients, their properties, use, adverse effects, and deficiency effects, as well as comments regarding their influence on certain illnesses. Some of the applications of the vitamins and minerals are at best empiric, since confirmation with controlled clinical trials is lacking. Tabulation of the interaction of vitamins and vitamins or vitamins and minerals also contains data that have not been fully confirmed or are involved with nutrients whose need in humans is not fully understood. Some of the symptoms describing various ailments are sufficiently nonspecific that misinterpretation can easily occur when the reader does not have sufficient medical background to discriminate. The tables of food and beverage composition are worthwhile, but the specific vitamin content of individual food items may be more than usually needed. Aside from the reference value of
COMMENTS ON THE WORK OF THE ARMY MEDICAL DEPARTMENT.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lines Incorrectly Inverted in Table
Authors: Brian D'onofrio, Arvid Sjölander, Paul Lichtenstein
Journal: JAMA Psychiatry (2014)

Aurélie M. Lasserre, MD; Jennifer Glaus, PhD; Caroline L. Vandeleur, PhD; Pedro Marques-Vidal, MD, PhD; Julien Vaucher, MD; François Bastardot, MD; Gérard Waeber, MD; Peter Vollenweider, MD; Martin Preisig, MD, MPH
REVERSIBILITY OF ENZYMES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Absorption of Some Glycol Ethers through Human Skin in Vitro
Authors: Paul H. Dugard, Michael Walker, Susan J. Mawdsley, Robert C. Scott
Journal: Environmental Health Perspectives (1984)

To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. The appearance of glycol ether in an aqueous "receptor" phase bathing the underside of the epidermis was quantified by a gas chromatographic technique. A final determination of tritiated water permeability was compared with initial values to establish any irreversible alterations in epidermal barrier function induced by contact with the glycol ethers. 2-methoxyethanol (EM) was most readily absorbed (mean steady rate 2.82 mg/cm2/hr), and a relatively high absorption rate (1.17 mg/cm2/hr) was also apparent for 1-methoxypropan-2-ol (PM). There was a trend of reducing absorption rate with increasing molecular weight or reducing volatility for monoethylene glycol ethers (EM, 2.82 mg/cm2/hr; 2-ethoxyethanol, EE, 0.796 mg/cm2/hr; 2-butoxyethanol, EB, 0.198 mg/cm2/hr) and also within the diethylene glycol series: 2-(2-methoxyethoxy) ethanol (DM, 0.206 mg/cm2/hr); 2-(2-ethoxyethoxy) ethanol (DE, 0.125 mg/cm2/hr) and 2-(2-butoxyethoxy) ethanol (DB, 0.035 mg/cm2/hr). The rate of absorption of 2-ethoxyethyl acetate (EEAc) was similar to that of the parent alcohol, EE. Absorption rates of diethylene glycol ethers were slower than their corresponding monoethylene glycol equivalents. Combination of intrinsic toxicity and ability to pass across skin contribute to assessment of hazards of contact with undiluted glycol ethers.
The Cover
Authors: Timothy F. Kirn
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mollie McGeown
Journal: BMJ (2005)

Founder of the Northern Ireland Renal ServiceMollie McGeown overcame gender prejudice in 1950s Northern Ireland medicine to build a career that changed the lives of thousands of people affected by kidney failure.After completing an MD thesis on endocarditis followed by a PhD in biochemistry, she was awarded a five year Medical Research Council fellowship and went on to develop an international reputation in calcium metabolism, hyperparathyroidism, and kidney stone disease.In 1959 she was appointed to set up a dialysis service for Northern Ireland and carried out the first successful dialysis on a uraemic patient later that year.This was a pivotal moment for patients in Northern Ireland with kidney failure.Over 200 patients in Northern Ireland at that time died each year from this cause.In 1971 a young woman treated by Mollie for pregnancy related renal failure founded the Northern Ireland Kidney Research Fund, which has to date raised £3m (€4.38m; $5.6m).Mollie was the patron of this fund up to her death.