tbuckley/cabot-search huggingface dataset:
Experientia, Basel
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Data and Omission of Trial Site and Personnel in: Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial
Authors: Laura Brockway, Leo Furcht, Catherine Deangelis
Journal: JAMA (2006)
Quality of randomized controlled trials reporting in the treatment of sarcomas.
Authors: M. Toulmonde, C. Bellera, S. Mathoulin-Pelissier, N. Bin Bui, A. Italiano
Journal: Journal of Clinical Oncology (2010)

10057 Background: Randomized controlled trials (RCTs) represent the best evidence in oncology practice. The aim of this study is to assess the reporting quality of sarcoma RCTs and to identify significant predictors of quality. Methods: Two investigators searched MEDLINE for pediatric and adult bone and soft-tissue sarcoma (STS) RCTs published between January 1988 and December 2008. The quality of each report was assessed using 15 items from the revised Consolidated Standards of Reporting Trials (CONSORT) statement. Each item was rated 1 point or 0 point, and the 15 scores were then combined to form the overall reporting quality score (OQS; range, 0 to 15 points). Concealment of allocation, appropriate blinding, and analysis according to intention-to-treat principle were assessed separately because of their crucial methodological importance. Each of these three key methodological domains was scored 1 point if the method was appropriate and 0 points if it was inappropriate or not clearly reported. The 3 scores were then combined to form the key methodological index score (MIS; range, 0–3). Results: We retrieved 72 relevant RCTs that included 16,029 patients. The median OQS was 11. Among the 72 studies, 28 (39%) did not report any of the three key methodological items, and only one article reported the three items. Indeed, allocation concealment, blinding, and analysis by intention to treat were reported in only 22 (30%), 10 (14%), and 23 (32%) of the 72 RCTs, respectively. Multivariable regression models revealed that high impact factor, publication after 1995, and sample size more than 140 were significantly associated with better OQS, whereas no factor was predictive of the MIS. Conclusions: Although, the overall quality of sarcoma RCT reporting has improved over time, reporting of key methodological issues remains poor. This may lead to biased interpretation of sarcoma trial results. No significant financial relationships to disclose.
Role of bone marrow-derived cells in experimental chronic pancreatitis
Authors: F Marrache, S Pendyala, G Bhagat, K S Betz, Z Song, T C Wang
Journal: Gut (2008)

<h3>Background:</h3> Chronic pancreatitis is a known risk factor for pancreatic adenocarcinoma. Recent work has pointed to a role for bone marrow-derived progenitor cells (BMDCs) in chronic inflammation-based carcinogenesis. Consequently, the role of BMDCs in chronic pancreatitis was investigated. <h3>Methods:</h3> The fate of BMDCs was followed using green fluorescent protein and the Y chromosome as bone marrow markers in gender-mismatched transplanted mice treated with repeated injections of cerulein for up to 45 weeks. The phenotype of engrafted BMDCs was assessed based on the co-expression of bone marrow and pancreatic markers. <h3>Results:</h3> After 45 weeks of cerulein treatment, mice developed severe chronic pancreatitis but no preneoplastic lesions. BMDCs did engraft in the pancreas. Most of the BMDCs were desmin positive and contributed to 5.12% (1.12%) (mean (SEM)) of the pancreatic stellate cell population. Pancreatic stellate cells derived from the bone marrow could be activated, as demonstrated by α-smooth muscle actin expression, suggesting a role in tissue repair. BMDCs could also be found in pancreatic ducts, based on dolichos biflorus agglutinin and cytokeratin 19 stainings, but at a much lower frequency (0.62% (0.11%)). <h3>Conclusion:</h3> BMDCs contribute to the pancreatic stellate cell population, suggesting a role in pancreatic tissue repair. In the absence of preneoplastic lesions, BMDCs contribute at a very low level to the ductal epithelium of the chronically inflamed pancreas. The role of BMDCs in pancreatic carcinogenesis remains to be defined.
Endothelin-1 and F2-isoprostane plasma levels prior to and following allogenic liver transplantation New England Medical Ctr., Nephritis, Renal Division, Emory Univ. and VA Medical Ctr., Atlanta, GA, and Vanderbilt Univ. Med. Ctr., Nashville, TN
Journal: Hepatology (1995)

Isoprostanes are a family of prostaglandin (PG) F and E isomers generated by free-radical attack from membrane bound arachidonic acid. We measured detectable levels of 8-iso-PGF2α in the perfusates of synaptosomes obtained from different areas of the rat brain cortex. A small but significant release of this isoprostane was found under basal conditions from all the areas explored; being lower in the dorsal cortex in respect to the frontal, parietal and occipital areas. Exposure of synaptosomes to a phospholipase A2 activator, i.e. calcium-ionophore A23187, an oxidant agent, such as hydrogen peroxide or amyloid β–peptide did not modify 8-iso-PGF2α release when these stimuli were applied separately. However, either hydrogen peroxide or amyloid β–peptide increased 8-iso-PGF2α release in a dose-dependent manner, when given in the presence of the calcium-ionophore A23187. Synaptosome treatment with a non-selective cyclooxygenase inhibitor (fenoprofen) did not modify 8-iso-PGF2α release in any way, but treatment with a water soluble antioxidant (Trolox C) completely suppressed isoprostane release under basal conditions, as well as after the oxidant injury induced either by hydrogen peroxide or amyloid β-peptide. We conclude that, in neuronal endings, 8-iso-PGF2α is generated under basal conditions and its formation may be increased in a dose-dependent fashion by oxidant stimuli through a cyclooxygenase-independent mechanism involving free radical-catalyzed oxidation of arachidonic acid on membrane phospholipids.
SIGNIFICANCE OF THE MD DEGREE
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Public Health and Aging: Health-Related Quality of Life Among Low-Income Persons Aged 45-64 Years—United States, 1995-2001
Journal: JAMA (2004)

Health-related quality of life (HRQOL) data are used to track population trends, identify health disparities, and monitor progress in achieving national health objectives for 2010. Low-income (i.e., annual household income of <15,000 dollars) adults aged > or =55 years have substantially more unhealthy days than low-income adults aged > or =65 years and adults aged 55-64 years with higher incomes. To verify this finding and determine whether it extends to low-income adults at younger ages, CDC analyzed HRQOL and related factors among a subset of respondents to the 1995-2001 Behavioral Risk Factor Surveillance System (BRFSS) surveys. This report summarizes the results of that analysis, which found that low-income adults aged 45-64 years have worse HRQOL than all other adults. Unemployment, inability to work, and activity limitation partially explain these HRQOL disparities in this age-income group. Targeting these risk factors and improving access to health care and social services (e.g., job training programs) could help increase the quality and years of healthy life and eliminate health disparities for persons in this age group.
A New Score to Determine the Probability of Finding An HLA Identical Unrelated Donor: A Promising Efficient Time and Cost Saving Method,
Authors: Valerie Dubois, Marie L Balere, Mohamad Sobh, Stephane Morisset, Helene Labussiere, Marie Y. Detrait, Franck E. Nicolini, Sylvie Rey, Valerie Mialou, Yves Bertrand, Mauricette Michallet
Journal: Blood (2011)
Military medicine offers support on land, sea, and in the air for US Bosnia peace enforcers
Authors: P. Gunby
Journal: JAMA (1996)

MEDICAL SUPPORT is available by air, land, and sea for the Operation Joint Endeavor implementation force that is seeking to enforce a cease-fire in the former Yugoslavia. Together, the former republics of Yugoslavia are about the size of Wyoming, bordering the Adriatic Sea, Italy, Austria, Hungary, Romania, Bulgaria, Greece, and Albania. Bosnia-Herzegovina, where North Atlantic Treaty Organization peace enforcers are at work, is slightly larger than Tennessee, earthquake-prone, and primarily mountainous. In addition to thousands of land mines, poisonous snakes and arachnids, upper respiratory tract infections, environmentally related diseases, and food-, water-, or insect-borne disorders (<i>JAMA</i>. 1994; 272:337-340), US troops are encountering work-associated and cold, wet weather—associated injuries. Lurking always in the background is the threat of violence—"unpredictable in this setting," as a US Army Medical Command booklet puts it—from one or another of the parties who have been warring for most of this decade. When a US military member
Editorial
Authors: R. Allan
Journal: Gut (1991)

The heavy thud as the current issue drops through the letter box heralds the first of three 'bumper' issues of Gut, each with 172 pages instead of the usual 124, and from January 1992 the journal will be increased to 144 pages per issue.In addition, the abstracts for the scientific meetings of the British Society of Gastroenterology will be published in 1992 as a separate camera-ready supplement and circulated in advance of the meeting.The 100 or so pages thus released annually will be used to increase the number of published scientific papers still further.These positive developments will reduce the interval from acceptance to publication of scientific papers from 11 to four months.This major improvement in the service to authors will ensure that new work is published as rapidly as possible and it will also keep our readers in the forefront of scientific advances.The journal now offers both a rapid peer review decision on submitted manuscripts and a short interval between acceptance and publication.The 'bumper' issue this year will be published without additional charge, but there will inevitably be an increase in 1992 to ensure that these improvements can be sustained.We believe, however,
Contents page + Editorial Board
Authors: Francis Kuhajda, Leslie Landree, Gabriele Ronnett, Laurence Mather, Elaine Weatherley, Jayesh Patel, Olivia Rossanese, Jorge Gala, Kellie Park, Michael Vasko, John Peters, Tim Hales, Jeremy Lambert, Evi Kostenis, Magali Waelbroeck, Graeme Trendsin
Journal: Trends in Pharmacological Sciences (2005)
Role of Vitamin K in Bone Metabolism
Authors: C. Vermeer
Journal: Annual Review of Nutrition (1995)

Vitamin K is a cofactor required for the formation of γ-carboxyglutamate (Gla) residues in proteins. Osteoblasts produce at least three different Gla-containing proteins: osteocalcin, matrix Gla-protein, and protein S. After cellular secretion of these proteins, the main part of each remains bound to the hydroxyapatite matrix in bone, but their function remains unclear. Part of the newly synthesized osteocalcin is also set free into the bloodstream, where it may be used as a diagnostic marker for bone formation. Several studies have demonstrated that a poor vitamin K status is associated with an increased risk of osteoporotic bone fractures. Whether vitamin K supplementation will reduce the rate of bone loss in postmenopausal women remains a matter of debate.
The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents
Authors: H SUN
Journal: Cardiovascular Research (2004)

Objective: Phosphoinositide 3-kinase (PI3K) is a key component in regulating myocardial growth, survival and contractility. LY294002 and wortmannin are two PI3K inhibitors used widely to establish the role of PI3K. The goal of this study was to examine the effects of acute application of LY294002 and wortmannin on cardiac myocyte contractility and underlying machanisms. Methods: Patch-clamp, indo-1 epifluorescence and video-edge detection techniques were used to measure outward K+ currents, action potentials (AP), Ca2+ transients and shortening of myocytes isolated from mouse left ventricular free wall. Results: In field-stimulated myocytes, LY294002 (10 μmol/l) increased Ca2+ transient amplitude by 23%, and cell shortening amplitude by 60% in the absence or presence of wortmannin, while wortmannin alone had no effect. LY294002 (but not wortmannin) prolonged AP duration by specifically inhibiting slowly inactivating K+ currents (i.e., the 4-aminopyrydine-sensitive Ik,slow1 and the tetraethylammonium-sensitive Ik,slow2), leading to an increase in sarcoplasmic reticular Ca2+ levels. It appeared that the AP prolongation was responsible for elevated contractility since AP-clamp of myocytes with prolonged APs (recorded in LY294002-treated myocytes) induced a 29% increase in cell shortening compared with control APs, while LY294002 application did not increase contractility in voltage-clamp studies using either step or AP depolarizations. Conclusions: The putative PI3K inhibitor LY294002 increases Ca2+ release and myocyte contractility via direct inhibition of cardiac Ik,slow and AP prolongation, thus limiting the usefulness of this agent in the analyses of the role of PI3K in heart function.
HIV
Authors: Richard A. Stein
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute duodenitis and duodenal ulceration after burns. Clinical and pathological characteristics
Authors: A. J. Czaja
Journal: JAMA (1975)

The clinical and pathological characteristics of Curling ulcer were defined by early and serial endoscopic examinations of the duodenum in 37 burned patients. Duodenal disease was present in 27 patients and occurred only in patients with burns involving more than 38% of the total body surface. Erosive "duodenitis" could occur within 12 hours after injury and was usually associated with acute gastric disease. Isolated duodenitis occurred only in patients with pancreatitis. Contrast roentgenograms did not reliably show the superficial mucosal disease. Duodenal ulcerations were present in 12 patients and developed on a background of diffuse superficial mucosal injury. Other complications in the patient's postburn course influenced disease progression. Hemorrhage occurred in six patients with duodenal disease, usually originating from a posterior duodenal ulcer. Uncomplicated ulcers invariably healed within five weeks after diagnosis. (<i>JAMA</i>232:621-624, 1975)
AMEBIC DYSENTERY
Authors: J. C. Geiger
Journal: JAMA (1933)

<h3>To the Editor:</h3> —It is not without grim humor that California medical men join their colleagues of the Southern states in observing the dramatization by Chicago health authorities of an outbreak of amebiasis recently recognized in that city. The 1927 Chicago survey (Kaplan, Bertha; Williamson, C. D., and Geiger, J. C.: Amebic Dysentery in Chicago,The Journal, March 26, 1927, p. 977) was of practical significance but the recommendations of this initial report obviously were not followed up. However, the present health authorities are to be congratulated on continuing this work and realizing its importance. Generally considered a "tropical disease," physicians in most of the United States have consistently refused to admit its potential menace as revealed by the extraordinarily high incidence of "carriers" without obvious symptoms (who have tissue damage, nevertheless) along with active cases found on systematic surveys of average populations in California and the South (Kofoid, A.
PLEA FOR THE EARLY RECOGNITION OF THE SYMPTOMS OF UROLOGIC LESIONS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis
Authors: Dan Jin, Jiwei Guo, Yan Wu, Jing Du, Lijuan Yang, Xiaohong Wang, Weihua Di, Baoguang Hu, Jiajia An, Lingqun Kong, Lei Pan, Guoming Su
Journal: Journal of Hematology & Oncology (2021)
Combination of cimetidine and alginic acid: an improvement in the treatment of oesophageal reflux disease. Cooperative Oesophageal Group.
Authors: J Mr
Journal: Gut (1991)

A new chewable tablet containing cimetidine 200 mg and alginic acid 500 mg, at a dosage of one tablet four times daily, was compared in a 12 week randomised study with the standard dosage of cimetidine (400 mg four times daily) in the management of oesophageal reflux disease. The dose of cimetidine continued unchanged throughout the study but the dose of the combination drugs could be increased after six weeks to two tablets four times a day if response was unsatisfactory. A total of 312 patients had data suitable for analysis. Sixty three per cent of those on the combination tablet completed the study without increasing their dose - that is taking cimetidine equivalent to half the standard dosage used in the control group. The improvement in heartburn symptoms was significantly greater in the combination group than in the group taking full dose cimetidine. There were no significant differences between the treatment groups in healing and improvement of the appearances of oesophagitis after 12 weeks, and healing rates were as expected from previous studies. The addition of alginic acid to cimetidine in this fixed combination tablet is an improvement in symptomatic treatment of oesophageal reflux disease.
ANOTHER VICTIM TO PLAGUE INVESTIGATION.
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal