tbuckley/cabot-search huggingface dataset:
Chronic rhinosinusitis
Authors: Alison Carter, Nikesh Dattani, Saiful Alam Hannan
Journal: BMJ (2019)

### What you need to know A 35 year old hairdresser presents to her general practitioner with a two year history of a blocked and runny nose. When she tried using an over-the-counter beclomethasone nasal spray, she did not notice any improvement. As she cannot breathe through her nose, she finds it hard to get to sleep and to exercise. Chronic rhinosinusitis is a common condition with a prevalence of 10.9%.1 It can have a major impact on quality of life, affecting sleep, exercise, and activity. Intranasal treatments are effective for most people2 but need to be used correctly and regularly. This article offers an evidence based approach to diagnosis and management. Aim to determine any precipitating factors or associated disease, and differentiate between structural and inflammatory nasal blockage (although both can be present). Try to establish the effect that symptoms are having on quality of life to help direct joint decision making and stepwise treatment. Acknowledging this impact can be useful in the consultation, as patients often feel embarrassed for seeking healthcare for a chronically blocked or runny nose, as they worry that such symptoms may be perceived as trivial.
Cerebral Angiography
Authors: Oscar Sugar
Journal: JAMA (1966)

Roentgenographic investigation of the blood vessels of the brain (cerebral angiography) is carried out to achieve several different goals: (1) to visualize the origin of intracranial bleeding, (2) to note the position of arteries and veins and identify any changes which may be produced by spaceoccupying lesions (tumor, clot, abscess) or by enlarged ventricles, (3) to visualize congenital vascular malformations or newly formed abnormal vessels within tumors, and (4) to see if there is vascular disease which may affect cerebral blood flow (spasm, arteriosclerosis, arteritis, thrombosis). Thus, angiography of the cerebral vessels may be useful whenever there is disease or disorder of the skull or its contents (including the eyes). <h3>Technique</h3> The most direct way of introducing radiopaque materials into the vessels leading to the brain is to make an incision over the carotid or vertebral arteries in the neck, isolate the artery, and inject directly through a needle. Open
Obesity drug, genetic studies renew hope for autism therapy
Authors: T. Hager
Journal: JAMA (1983)

Joey looks like a normal 3-year-old. But left by himself in a room full of toys, he ignores everything except a mechanical top that he spins again and again, staring, flapping his hands, and squealing. He plays only with that top, in only that way, over and over. Joey's fixed, repetitive actions seem as mechanical as his favorite plaything. Joey is autistic. At the recent meeting of the National Society for Children and Adults With Autism in Salt Lake City, participants saw several videotapes of Joey playing as part of a presentation on a new treatment for this baffling developmental disorder. Joey was next shown after receiving experimental therapy with fenfluramine hydrochloride (a sympathomimetic amine used to treat obesity) for four months. In the same room, with the same toys, he now chose a toy train set, first putting together tracks, then pushing the train along while making choo-choo noises.
Staphylococcal Parotitis
Authors: Robert G. Petersdorf, Ben R. Forsyth, David Bernanke
Journal: New England Journal of Medicine (1958)

STAPHYLOCOCCAL infections acquired in hospitals continue to present serious problems, particularly since strains of nosocomial origin are frequently resistant to virtually all antibiotics. During the past five months, we have observed 7 patients with a virulent, and hitherto rare, form of hospital-acquired staphylococcal disease — namely, parotitis. Although occasionally seen in postoperative patients, this disease has been thought to be on the wane.1 It is the purpose of this report to describe briefly 7 cases of staphylococcal parotitis (Table 1), only 3 of which occurred postoperatively, to summarize the clinical picture, and to describe antibiotic-sensitivity patterns and phage types of . . .
Cardiopulmonary arterioarterial fistulae after myocardial revascularization. A coronary steal syndrome
Authors: C. A. Pierach
Journal: JAMA (1971)

In a woman with typical angina pectoris and angiographic evidence of marked reduction of coronary flow, both internal mammary arteries were implanted into the myocardium. Angiography 19 and 24 months later showed fistulous communications between the right internal mammary, the left coronary, and the left pulmonary arteries, indicating the possibility of a coronary steal syndrome. Dense adhesions traversed by numerous small arteriolized vessels between the lingula of the left lung and the anteriolateral surface of the left ventricle were subsequently divided. Her anginal pain subsided. No similar case has been found in the literature.
Commentaire de travail de M. F. Madhoun et al., pp.86
Journal: Endoscopy (2013)

See also: The diagnostic accuracy of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of solid pancreatic lesions: a meta-analysisEndoscopy 2013; 45(02): 86-92DOI: 10.1055/s-0032-1325992
Statement on Hypertension in the Elderly
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A DENTAL CLINIC FOR CHILDREN IN A SETTLEMENT
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumonia--pre-existing lung disease.
Journal: BMJ (1971)

Case 3-Chronic obstructive lung disease.HOUSE PHYSICIAN: This 70-year-old granite worker has longstanding chronic obstructive bronchitis.He recently developed an upper respiratory tract infection, and was admitted with bronchopneumonia.He was febrile, cyanosed, and coughing up purulent sputum.DR.PALMER: Unlike our previous patients, this man has chronic obstructive lung disease-"C.O.L.D.".Therefore, it is to be expected that the bronchial tree below the larynx, which is normally sterile, will be populated with pneumococci, usually of low virulence, and more importantly with Haemo- philus influenzae.If the infection develops in hospital a penicillinase-producing staphylococcus must be considered as a possible pathogenic organism.Of course, one must never forget the possibility of these patients having tuberculosis.PROFESSOR MACGREGOR: I agree.If tubercle bacilli are not looked for the patient may not be diagnosed until he infects someone else.HOUSE PHYSICIAN: Pneumococci and H. influenzae have been isolated.There are no acid-fast bacilli.STUDENT: Because H. influenzae is not adequately sensitive to ordinary penicillins presumably you are going to use a broad-spectrum antibiotic.DR.WOOD: Yes.The much wider range of activity of ampicillin compared with penicillin G, though it has a very similar structure, makes it a drug of first choice.As it is acid-stable, it is given by mouth in a dose of 250-500 mg, six hourly.DR. HOWIE: In some hospitals the dose recommended is 1 g four times a day, which is at least double the highest normal dose that a general practitioner prescribes.In my experience even 500 mg four times a day causes a definite problem with diarrhoea-and rashes.The diarrhoea, perhaps, is not a problem to a hospital, where there are nurses, but may be the last straw in a household where an elderly couple are struggling along together, one ill and the other just able to cope.DR.
ARTIFICIAL ANTIBODIES
Authors: Clarence L. Wood
Journal: JAMA (1942)

<h3>To the Editor:—</h3> In the August 15 issue ofThe Journalappears an article on artificial antibodies. I note that you use a bibliography of authors dating from 1927 to the present with the exception of the 1915 Russian authors, who heated toxin with horse serum. An American scientist, immunologist, physician and major (retired) in the Medical Corps of the United States Army, Dr. Frank M. Wood, did original researches on this subject in 1912. Many processes are in fact part and parcel of the original method of producing detoxified antigens (or partial antibodies) by this author, namely: The use of trypsin by Sdrawosmisslow and Kimmelstiel is part of the author's process. Addition of alkali and slow return to neutrality, and incubation as used by Pauling and Campbell is part of his process. Dr. Wood now lives at 1751 South La Brea Avenue, Los Angeles. His original researches
Involvement of cell calcium and transmembrane potential in control of hepatocyte volume
Authors: W Khalbuss
Journal: Hepatology (1991)

This study examined the role of hepatocyte calcium and cytoskeleton in activation of hyposmotic stress-induced increases in hepatocyte transmembrane potential and control of cell volume. Hepatocyte transmembrane potential was measured by glass microelectrodes in mouse liver slices before and after exposure to hyposmotic medium. Hepatocytes were loaded with tetramethylammonium by briefly exposing liver slices to nystatin, a cation poreforming antibiotic. Changes in hepatocyte steady-state water volume were determined by changes in intracellular tetramethylammonium activity measured with tetramethylammonium-sensitive, double-barrel micro-electrodes 4 min after exposure to hyposmotic medium. Hyposmotic stress of 74% of the control osmolality (approximately 280 mOsm) hyperpolarized hepatocyte transmembrane potential by 1.83 times the control hepatocyte transmembrane potential, and cell water volume increased by a factor of 1.19. The Ca2+ channel blocker verapamil (100 mumol/L) completely inhibited hyposmotic stress-induced hyperpolarization of hepatocyte transmembrane potential. This inhibitory effect diminished at doses of 37.5 or 50 mumol/L, but even these hyperpolarizations were decreased significantly compared with control. Hyposmotic stress during added verapamil dosage (50 mumol/L) also resulted in 23% greater cell swelling compared with control. Ca(2+)-free medium plus ethylene glycol-bis (beta-aminoethylether)-N,N'-tetraacetic acid (5 mmol/L) inhibited hyposmotic stress-induced increases in hepatocyte transmembrane potential and resulted in 16% greater cell swelling compared with control. Calmodulin inhibitors trifluoperazine (100 mumol/L) and promethazine (100 mumol/L) inhibited the hyperpolarization of hepatocyte transmembrane potential caused by hyposmolality, as did 3,4,5-trimethoxybenzoate 8-(N,N-diethylamino)octyl ester) (50 mumol/L), which inhibits mobilization of Ca2+ from intracellular stores. Cytochalasin B (50 mumol/L), which disrupts microfilaments, also inhibited hyperpolarization of hepatocyte transmembrane potential with osmotic stress.(ABSTRACT TRUNCATED AT 250 WORDS)
Liver Disease in Heroin Addicts
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gas Aid to Endarterectomy Developed
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Homicides Among Children and Young Adults—Puerto Rico, 1999-2003
Journal: JAMA (2006)

Interpersonal violence causes substantial morbidity and mortality worldwide and poses a considerable economic burden, equivalent to 4%-5% of the gross national product in certain countries. The Commonwealth of Puerto Rico is a U.S. territory with a 2004 population of approximately 3.9 million. In Puerto Rico, homicides were the 12th leading cause of death overall in 2003, ranking fifth among males and 15th among females. This report summarizes an analysis of death certificate data on violent deaths of children and young adults in Puerto Rico during 1999-2003, which determined that 93% of homicide victims aged <30 years were young males, the most common method of homicide was assault by firearm discharge, and the rate of homicide among males aged 25-29 years increased during the period. To address this problem, the Puerto Rican government has initiated a comprehensive strategy that includes enhancing an integrated surveillance system for fatal and nonfatal assault, supporting research on interpersonal violence, and establishing local prevention programs (e.g., violence prevention curricula in selected schools).
In Brief
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Single cell RNA-seq atlas of a regenerating liver in mice reveals early Kupffer cell proliferation
Authors: Daniel Sanchez-Taltavull, Tess Brodie, Zindel Joel, Noëlle Dommann, Bas Surewaard, Nicolas Melin, Adrian Keogh, Paul Kubes, Daniel Candinas, Guido Beldi, Deborah Stroka
Journal: Journal of Hepatology (2020)
OPHTHALMOLOGY.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interim Recommendations for Protecting Workers From Exposure to Bacillus anthracis in Work Sites in Which Mail Is Handled or Processed
Journal: JAMA (2001)

CDC has developed interim recommendations to assist personnel responsible for occupational health and safety in developing a comprehensive program to reduce potential cutaneous or inhalational exposures to Bacillus anthracis spores among workers in work sites in which mail is handled or processed. Such work sites include post offices, mail distribution/handling centers, bulk mail centers, air mail facilities, priority mail processing centers, public and private mail rooms, and other settings in which workers are responsible for handling and processing mail. The recommendations are based on the limited information available on methods to avoid infection and on the effectiveness of various prevention strategies. These recommendations will be updated as new informat on becomes available.
Prevention 98 Conference: Translating Science Into Action
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful use of a paracorporeal left ventricular assist device in man
Authors: R. L. Berger
Journal: JAMA (1980)

A paracorporeal left ventricular assist device (LVAD) with a capacity to pump 8 L/min of blood was employed in a clinical trial, and this report details the first survivor. A 60-year-old man could not be separated from the pump oxygenator following coronary artery bypass grafting, and, therefore, an LVAD was employed. Almost the entire left ventricular workload was assumed by the mechanical pump so that the myocardium was allowed to rest and recover. The LVAD support was continued for 105 hours. It provided satisfactory total body perfusion with maintenance of good hemodynamics—without serious deleterious effects on hematologic factors. The patient is alive and active without cardiac symptoms 16 months after his operation. The total experience with 13 LVAD implantations warrants continuation of the clinical trials in selected patients. (<i>JAMA</i>243:46-49, 1980)