tbuckley/cabot-search huggingface dataset:
Association between vitamin D supplementation and mortality: systematic review and meta-analysis
Journal: BMJ (2020)

two studies were included twice by mistake in the outcome of all cause mortality, which resulted in the double counting of some participants.After removing the duplicate studies, the effect estimates and the confidence intervals did not change.Furthermore, some studies' cancer incidence data were erroneously attributed to cancer mortality, and the risk ratio and 95% confidence interval of cancer mortality changed from 0.84 (95% confidence interval 0.74 to 0.95) to 0.85 (0.74 to 0.97).An additional sensitivity analysis using trial duration rather than long term follow-up (supplementary eTable 7) did not change the article's overall finding.These corrections affect the article text, table 1, figures 1-3, and the supplementary material, and do not change the article's results or interpretation.The authors apologise for the errors and regret any inconvenience caused.
<i>Hospitals, Dispensaries, and Nursing. Papers and Discussions in the International Congress of Charities, Correction, and Philanthropy, Section III, Chicago, June</i>12<i>to</i>17, 1893. Edited by John S. M. D., and Henry M. Hurd, M. D. Baltimore: The Johns Press. London: The Scientific Press (Limited)
Authors: C. B. B.
Journal: American Journal of Psychiatry (1894)
Stammering.
Authors: F. W. Higgins
Journal: JAMA (1898)

No action will probably be taken by the Surgeon-General of the Army looking to the selection of the best men for the new position until these positions have an actual existence by legislation; but medical men desirous of filling them may do much in the way of special preparation to meet examining boards, if they recognize the likelihood of the speedy appointment of such boards. We know from the "Circular of Information for Candidates seeking Appointment in the Medical Corps of the United States Army," that applications for permission to appear for examination are in order at all times. This circular, issued from time to time by the Surgeon-General of the Army, gives the Constitution of the Medical Department at the date of its issue, and states the pay and emoluments and the duties and privileges of army medical officers, the method of making application and the manner and scope
OBSERVATIONS REGARDING THE UNEDUCATED RETINA.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase Ib/II Study of Combined Obinutuzumab and High-Dose Methylprednisolone (HDMP) As Treatment for Patients with Chronic Lymphocytic Leukemia (CLL)
Authors: Januario E. Castro, Michael Y. Choi, Carlos I. Amaya-Chanaga, Natalie Nguyen, Amine Ale-Ali, Thomas J. Kipps
Journal: Blood (2015)
Leads from the MMWR. Winter plague--Colorado, Washington, Texas, 1983 to 1984
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic Malaria.
Journal: JAMA (1927)

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Helpful Publications for Residents
Journal: JAMA (1992)

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Developmental Toxicity and Structure/Activity Correlates of Glycols and Glycol Ethers
Authors: E. Marshall Johnson, Bradley E. G. Gabel, John Larson
Journal: Environmental Health Perspectives (1984)

In recent years, the National Toxicology Program (NTP) has selected numerous glycol ethers for testing in routine laboratory mammals to ascertain the magnitude of their ability to injure the conceptus. From the lists available of ongoing and projected NTP test chemicals, a series of glycol ethers was selected for examination in vitro in the hydra assay. Also tested were additional chemicals of similar molecular configuration and/or composition. This short-term screening test placed the 14 glycols and glycol ethers tested into a rank order sequence according to their degree of hazard potential to developmental biology, i.e., their ability to interfere with the developmental events characteristic of all ontogenic systems. They were ranked according to the difference between the lowest dose or concentration overtly toxic to adults (A) and the lowest concentration interfering with development (D) of the artificial embryo of reaggregated adult hydra cells and the A/D ratio. Published data from mammalian studies were available for a few of the test chemicals, and in each instance the hydra assay was in direct agreement with the outcomes reported of the more elaborate and standard animal tests. Ethylene glycol and ethylene glycol monomethyl ether were shown by both standard evaluations in mammals, and by the hydra assay, to disrupt embryos only at or very near to their respective adult toxic doses, whereas the mono-ethyl ether perturbed development at approximately one-fifth of the lowest dose overtly toxic to adults.(ABSTRACT TRUNCATED AT 250 WORDS)
THE TEACHING OF PHARMACOLOGY.
Journal: JAMA (1907)

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Commentary
Authors: Alvan R. Feinstein
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXPERIMENTATION ON THE CORD AFTER DECAPITATION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Control of diabetes during pregnancy: 1985
Authors: J. S. Skyler
Journal: JAMA (1986)

Since the availability of insulin, commencing in 1923, women with type I or insulin-dependent diabetes mellitus have been able to contemplate pregnancy. The first major review of the subject in the postinsulin era was compiled by Eric Skipper<sup>1</sup>in 1933. At the London Hospital, he collected data from 37 pregnancies in 33 diabetic women, and based his report on these plus data on 136 pregnancies in 118 women published subsequent to 1923. He noted that the maternal mortality in the published cases was 9.3%, with a further 3.4% of mothers dying within two years of delivery. The fetal mortality was 45.2% in the published cases and 40.5% in his own series. In conventional textbooks of the last few decades, pregnancy in diabetes has been viewed as a circumstance of maternal jeopardy, in terms of maternal survival and progression of diabetic complications as well as of substantial fetal morbidity and mortality,
White matter lesions predict outcome in late depression
Journal: BMJ (1998)

Multiple doses of anticholinergics are beneficial in severe, acute childhood asthmaThe addition of anticholinergics to 2 agonist inhalations remains controversial in the treatment of children and adolescents with asthma exacerbations.To examine the efficacy of three management strategies for adding anticholinergics to 2 agonists, Plotnick and Ducharme (p 971) systematically reviewed 10 randomised controlled trials, including single dose, multiple doses (predetermined protocol), and multiple doses (flexible protocol).Only the addition of multiple doses of anticholinergics to 2 agonists in a predetermined protocol reduced the risk of hospital admission (by 30%) and improved pulmonary function tests.Eleven children would need to be treated to avoid one admission.The use of anticholinergics in mild to moderate asthma is not supported by the available evidence.The number and size of pooled studies remain small, thus the conclusions are subject to change with future larger trials. Warm clothing and housing prevent excess winter mortalityCold weather increases death rates from heart disease, stroke, and all causes in western Europe.Donaldson et al studied mortality in Yakutsk in east Siberia, where temperatures average -26.6°C from October to March (p 978).Overall daily death rates did not rise even at temperatures of -48.2°C.An increase in deaths from respiratory disease below -20°C was balanced by a fall in deaths from injury at this temperature.The stable death rate is attributed to very warm outdoor clothing and housing as well as a reduction in outdoor trips at temperatures below -20°C.The authors suggest that most of the excess winter mortality in western Europe is preventable by personal cold protection.
Penicillin-induced encephalopathy in uremic patients
Authors: H. A. Bloomer
Journal: JAMA (1967)

Massive doses of potassium penicillin G, given intravenously to four patients with renal failure, resulted in decreased consciousness, myoclonic jerking, and seizures. Although similar cases have been reported, the syndrome is not well known. The frequency of this serious complication demands that caution be used in administering large doses of penicillin to azotemic patients.
Perinatal Mortality
Authors: Tom Brewer
Journal: JAMA (1966)

<h3>To the Editor:—</h3> It appears to me that Finnerty and Bepko (<b>195</b>:429, 1966) make a serious misstatement of scientific fact: Thiazide diuretics administered in the phase of sodium retention and generalized vasoconstriction do not significantly reduce the plasma volume, nor significantly alter the hemoconcentration, and therefore do not reverse the toxemic process. The facts are that the severely toxemic patient has a contracted plasma volume, and no rational physician would want to reduce it further. Saluretic diuretics reduce this contracted plasma volume further in those women who have abnormally low serum albumin concentrations, thus making the hemoconcentration more pronounced. I have reported a case (<i>Amer J Obstet Gynec</i><b>83</b>:1352, 1962) in which a severely toxemic patient died, directly as the result of excessive use of saluretic diretics, and another who almost died, but whose life was saved by the intravenous administration of human serum albumin. Administration of human
Annales D'Oculistique, Paris
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5153: Measuring T-cell avidity and enrichment using an acoustic force based technology
Authors: Ali Raja, Wouter Scheper, Elena Merino, Rens Braster, Gerrit Sitter, Felix Oswald, Ton Schumacher, Andrea Candelli, Leif Anderson
Journal: Cancer Research (2019)

Abstract The key driver for effective immunotherapies is the overall strength binding of the immune cell and the target cell (e.g. tumor cells). The overall strength is known as ‘avidity’, a parameter reflecting interaction efficiency. One of the main obstacles has been the generation of immunotherapies promoting effective and long-lasting immune responses, due to the lack of tools measuring this parameter. Here, we have made used of acoustic forces as a novel method to isolate immune cells based on their avidity to specific targets, such as (tumor) cells. The force that cell-target need to experience to be separated is called ‘rupture force’. In this study, we were able to identify the rupture forces of tumor specific and non-specific T cells and separate these different populations applying controllable acoustic forces. T cells engineered with a melanoma antigen recognizing T-cell receptor needed 6 times more relative force than the control, non-specific T cells, to be separate from their melanoma cells. These findings indicate that the specific melanoma T cells bind with higher efficiency and higher avidity than the non-specific ones, and that they can be separated with this method. Furthermore, 1.4 to 3.6-fold enrichment of high avidity T cells from a mixed specific: non-specific (1:10) T cell population was obtained after their isolation using acoustic forces and confirmed using FACS measurements. Therefore, we demonstrate here that acoustic forces can be use as a tool to measure avidity. Citation Format: Ali Raja, Wouter Scheper, Elena Merino, Rens Braster, Gerrit Sitter, Felix Oswald, Ton Schumacher, Andrea Candelli, Leif Anderson. Measuring T-cell avidity and enrichment using an acoustic force based technology [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5153.
Globozoospermia revisited
Authors: A.H.D.M. Dam, I. Feenstra, J.R. Westphal, L. Ramos, R.J.T. van Golde, J.A.M. Kremer
Journal: Human Reproduction Update (2006)

Globozoospermia is a rare (incidence <0.1%) but severe disorder in male infertility. Total globozoospermia is diagnosed by the presence of 100% round-headed spermatozoa lacking an acrosome. It is still unclear whether patients whose ejaculate contains both normal and globozoospermic cells (partial globozoospermia) suffer from a variation of the same syndrome. Apart from the fact that affected males suffer from reduced fertility or even infertility, no other physical characteristics can be associated with the syndrome. ICSI is a treatment option for these patients, although low fertilization rates after ICSI show a reduced ability to activate the oocyte. In globozoospermic cells, the use of acrosome markers has demonstrated an absent or severely malformed acrosome. Chromatin compaction appears to be disturbed but is not consistently over- or undercondensed. In some cases, an increased number of cells with DNA fragmentation have been observed. The analysis of the cytogenetic composition revealed an increased aneuploidy rate in some cases. Nonetheless, no increased number of spontaneous abortions or congenital defects has been reported in pregnancies conceived after ICSI. The pathogenesis of globozoospermia most probably originates in spermiogenesis, more specifically in acrosome formation and sperm head elongation. In several knockout mouse models, a phenotype similar to that in humans was found. Together with the occurrence of affected siblings, these findings indicate a genetic origin, which makes globozoospermia a good candidate for genetic analysis. More research is needed to elucidate the pathogenesis of human globozoospermia to further understand globozoospermia as well as (abnormalities in) spermiogenesis and spermatogenesis in general.
CONSTRUCTIVE EPIDEMIOLOGY
Authors: R. Ross
Journal: BMJ (1929)

B8before thoso surgeons who have access to, and experience With, radium will cease to amputate the breast.I hope to see the time when the same can be said of excisioln of the rectum.Whlen .passing in review tlle results of myr work with radium d-uring the last four -years I do not doubt that, with increasing experience, we shall be able to cure year by year a higher percentage of inoperable cases, alnd I am satisfied that with judicious selection of cases we can assist those wlho have passed beyond the hope of cure by alleviating their symptoms and prolonging their, lives.