tbuckley/cabot-search huggingface dataset:
Role of the Cerebellum and the Vestibular Apparatus in Regulation of Orthostatic Reflexes in the Cat
Authors: NOBUTAKA DOBA, DONALD J. REIS
Journal: Circulation Research (1974)

The contribution of the fastigial nucleus and the vestibular nerves (eighth cranial nerves) to the orthostatic reflexes in anesthetized, paralyzed cats was studied. Bilateral lesions of the rostral fastigial nucleus resulted in impairment of the reflex changes in blood pressure, femoral arterial flow, and resistance evoked by head-up tilting to 30° or 60°. The deficit consisted of an increase in the magnitude of the initial fall in blood pressure during tilting. The effects on blood pressure were paralleled by decreased vasoconstriction in the femoral artery. Extracranial lesions of the vestibular nerves produced comparable deficits which were not enhanced by subsequent lesions of the fastigial nucleus. Denervation of the baroreceptors impaired the reflexes, and subsequent lesion of the fastigial nucleus increased this deficit. The pressor response evoked by electrical stimulation of the rostral fastigial nucleus also reversed the deficit in orthostasis produced by hemorrhage. Small doses of sodium pentobarbital which did not alter the resting blood pressure or the pressor response to carotid occlusion impaired the responses to stimulation of the fastigial nucleus and tilting. Therefore, the rostral fastigial nucleus, which might be triggered by the vestibular apparatus, appears to participate in concert with the baroreceptors in the initiation and possibly the maintenance of the orthostatic reflexes.
Yemen needs a concrete plan—now
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2018)

More than 3 years into the current conflict, the situation in Yemen has reached catastrophic proportions. These have been exacerbated by the collapse of the national economy and by intense fighting around Hodeidah, the country's principal port on the Red Sea where most commodities, including food and medicines, enter the largely import-based Yemeni market. The planned peace negotiations are dependent on the goodwill of two warring parties whose disregard for international law has already led to large civilian casualties and the destruction of essential infrastructure such as health facilities, water systems, roads, and markets.
The Strange Case of the Cure of Cancer
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DEGENERACY OR OCCUPATION STRESS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Esophagogastric Tumors
Authors: R Lambert
Journal: Endoscopy (2000)

Palliative endoscopic treatment of esophagogastric cancer is now possible using expandable metal stents. The properties, advantages, and drawbacks of these stents have been extensively analyzed, and there is no doubt that they are now easy and safe to introduce, without serious morbidity. However, the frequency of persistent thoracic pain and delayed complications, as well as the high rate of repeat interventions required, justify limited use of the procedure. The major indication for the procedure is dysphagia due to cancer in the esophagus or at the cardia. Enteral stents have been used in the treatment of malignant duodenal or jejunal stenoses, but the results are poor. A promising new area is the treatment of benign stenoses using expandable and biodegradable stents. It may be possible to use this technique for surgical anastomoses after tumor resection.
THE IDEAL PRELIMINARY EDUCATION FOR MEDICAL STUDENTS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lipedema
Authors: Adolf Singer
Journal: JAMA (1974)

<h3>To the Editor.—</h3> I do not believe that Stallworth et al (228:1656, 1974) have proven their case for a definite clinical entity of "lipedema" in the patients described. The plasma lipid values seem high, but are of no significance unless the controls were patients of comparable sex, age, and mean weight; this is not stated. The origin of tissue lipid values would similarly have to be a group of middle-aged, overweight patients with fat legs but no symptoms, to make their figures valid. I have seen and treated many patients with a clinical picture identical with that described in their paper. Many of these patients have clinical evidence of past phlebitis; others do not. Both groups have episodes of painful, lumpy swellings in their legs, that may be accompanied by redness, heat, and tenderness in the affected areas. This picture frequently takes many weeks to resolve and may leave some
Erratum: Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori
Authors: A Fujikawa, D Shirasaka, S Yamamoto, H Ota, K Yahiro, M Fukada, T Shintani, A Wada, N Aoyama, T Hirayama, H Fukamachi, M Noda
Journal: Nature Genetics (2003)
Cardiopulmonary resuscitation and the ultimate coronary care unit
Authors: K. M. McIntyre
Journal: JAMA (1980)

The work of the National Conference on Standards and Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiac Care (ECC) held in Dallas in September 1979 appears in this issue ofThe Journal. This updates the 1974<i>JAMA</i>"Standards,"1 more than 3 million reprints of which have been circulated worldwide. Questions as to where we have been in CPR and ECC, where we are going, and where we should be going were addressed in the context of the nearly 1,000 sudden deaths per day in this country. While the Conference focused on the treatment of cardiac emergencies, the need for new initiatives and strategies working in parallel with emergency care was well appreciated. Notice was taken of the need for physicians and the medical community to embrace a new prescription for dealing with sudden death caused by coronary heart disease (CHD) that continues to emphasize improvement in capabilities for dealing effectively
Book Review Color Atlas of the Hair, Scalp and Nails By R. Baran, R.P.R. Dawber, and G.M. Levene. 192 pp., illustrated. St. Louis, Mosby-Year Book, 1991. $60. Atlas of Infections of the Skin By Anthony du Vivier. 114 pp., illustrated. New York, Gower Medical, 1991. $65. (Distributed in the U.S. by J.B. Lippincott, Philadelphia.) Atlas of Skin Cancer By Anthony du Vivier. 235 pp., illustrated. New York, Gower Medical, 1991. $95. (Distributed in the U.S. by J.B. Lippincott, Philadelphia.)
Authors: James E. Rasmussen
Journal: New England Journal of Medicine (1992)
Disparities in Deaths From Stroke Among Persons Aged &amp;lt;75 Years—United States, 2002
Journal: JAMA (2005)

services.To help identify root causes of high IMRs and develop new strategies for reducing IMRs, in 2004, a State Infant Mortality Collaborative 8 was formed, which includes CDC, the Association of Maternal and Child Health Programs, and teams from five states (Delaware, Hawaii, Louisiana, Missouri, and North Carolina). REFERENCES available*Data suggest that the increase in IMR in 2002 might be largely attributed to an increase in the number of infants, across most racial/ethnic populations, who were born at extremely low birthweights (i.e., Ͻ1 pound 10.5 ounces [750 grams]) and, therefore, had less chance for survival. 5
Evaluation of the complication rate as a measure of quality of care in coronary artery bypass graft surgery
Authors: J. H. Silber
Journal: JAMA (1995)

<h3>Objective.</h3> —To determine whether hospital rankings based on complication rates provide the same information as hospital rankings based on mortality rates. <h3>Design.</h3> —A retrospective study of in-hospital death, complication, and death following complication (failure to rescue). Hospitals were ranked using residuals based on the difference between the observed and the expected number of events (from logistic regression models); rankings were compared using Spearman rank correlations. <h3>Setting.</h3> —Hospitals performing coronary artery bypass graft (CABG) surgery in the 1991 and 1992 MedisGroups National Comparative Data Bases. <h3>Patients and Data Sets.</h3> —Record abstraction data for 16 673 patients who underwent CABG procedures at 57 hospitals, linked with data from the 1991 American Hospital Association Annual Survey. <h3>Results.</h3> —After adjusting for patient admission severity of illness, there were low correlations between hospital rankings based on death or failure to rescue and those rankings based on complication (death vs complication,<i>r</i>=0.07,<i>P</i>=.58; failure to rescue vs complication,<i>r</i>=-0.22,<i>P</i>=.11). In addition, many hospital characteristics that are generally associated with a higher quality of care were associated with higher complication rates but with expected or lower-than-expected mortality rates. <h3>Conclusions.</h3> —Hospital rankings based on complication rates provide different information than those based on mortality rates. Until more is known about these differences, complication rates should not be used to judge hospital quality of care in CABG surgery. (<i>JAMA</i>. 1995;274:317-323)
A virus-induced molecular mimicry model of multiple sclerosis
Authors: Julie K. Olson, J. Ludovic Croxford, Miriam. A. Calenoff, Mauro C. Dal Canto, Stephen D. Miller
Journal: Journal of Clinical Investigation (2001)

Molecular mimicry is the process by which virus infection activates T cells that are cross-reactive with self antigens. Infection of SJL/J mice with the neurotropic picornavirus Theiler’s murine encephalomyelitis virus (TMEV) leads to a progressive CD4+ T cell–mediated demyelinating disease similar to multiple sclerosis. To study the potential of virus-induced molecular mimicry to initiate autoimmune demyelination, a nonpathogenic TMEV variant was engineered to encode a 30-mer peptide encompassing the immunodominant encephalitogenic myelin proteolipid protein (PLP139-151) epitope. Infection with the PLP139-151–encoding TMEV led within 10–14 days to a rapid-onset paralytic demyelinating disease characterized by PLP139-151–specific CD4+ Th1 responses; insertion of a non-self ovalbumin sequence led to restoration of the normal late-onset disease. Early-onset disease was also observed in mice infected with a TMEV encoding PLP139-151 with an amino acid substitution at the secondary T cell receptor (TCR) contact residue (H147A), but not in mice infected with TMEV encoding a PLP139-151 substitution at the primary TCR contact (W144A). Most significantly, mice infected with TMEV encoding a Haemophilus influenzae mimic peptide, sharing only 6 of 13 amino acids with PLP139-151, displayed rapid-onset disease and developed cross-reactive PLP139-151–specific CD4+ Th1 responses. To our knowledge, this is the first study showing that a naturally infectious virus encoding a myelin epitope mimic can directly initiate organ-specific T cell–mediated autoimmunity.
“The Italian multicentre study on noninvasive ventilation in chronic obstructive pulmonary disease patients”. E. Clini, C. Sturani, A. Rossi, S. Viaggi, A. Corrado, C.F. Donner, N. Ambrosino, on behalf of the Rehabilitation and Chronic Care Study Group, Italian Association of Hospital Pulmonologists (AIPO).<i>Eur Respir J</i>2002; 20: 529–538.
Journal: European Respiratory Journal (2002)

Unfortunately, there was an error in the Acknowledgements section on page 537.In the list of Participating centres and investigators the participating centre of Perugia was wrongly named.The corrected name of the participating centre is printed below along with the associated investigators.
Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats*1
Authors: S KRAHENBUHL
Journal: Hepatology (1995)

Lipid peroxidation and antioxidative mechanisms were investigated in liver mitochondria from bile duct ligated rats (BDL rats) and correlated with the activity of enzyme complexes of the electron transport chain. In comparison to pair-fed control rats, BDL rats had increased concentrations of thiobarbituric acid reacting substances (TBARS) per gram of liver and per milligram of mitochondrial protein 3, 7, 14, and 28 days after surgery. The hepatic glutathione (GSH) content was decreased in BDL rats 28 days after surgery when expressed per gram of liver but equal between BDL and control rats when expressed per liver. The mitochondrial GSH content was decreased in BDL rats by 20% to 33% from day 7 after surgery. The concentrations of ubiquinone-9 and ubiquinone-10, substances involved in electron transport and efficient antioxidants, were both decreased in BDL rats 14 and 28 days after surgery per gram of liver and per milligram of mitochondrial protein. When expressed per liver, ubiquinone-9 was decreased in BDL rats from day 7 after surgery. In comparison with controls, the decrease in total mitochondrial ubiquinone content in BDL rats averaged 52% 14 days and 38% 28 days after surgery. The activity of the succinate:ferricytochrome c oxidoreductase (complexes II and III of the electron transport chain) was decreased in BDL rats at days 7, 14, and 28 after surgery, and the activity of the ferrocytochrome c:oxygen oxidoreductase (complex IV) was reduced at 14 and 28 days after surgery. The mitochondrial concentration of TBARS showed a negative and the concentrations of GSH and ubiquinone a positive correlation with the activity of the succinate:ferricytochrome c oxidoreductase. We conclude that the mitochondrial concentration of antioxidants such as GSH and ubiquinone decreases in BDL rats, whereas the concentration of lipid peroxidation products increases. Hepatic mitochondrial dysfunction in BDL rats may at least partially result from oxidative damage to mitochondrial lipids and/or proteins.
INTRADERMAL VACCINATION
Authors: Louis T. Wright
Journal: JAMA (1925)

<h3>To the Editor:</h3> In your answer to the question as to the relative merits of the present intradermal method of vaccination, and its advantages over the old scratch method (The Journal, January 17, p. 223), you failed to mention that one of the chief advantages of the intradermal method is that it gives a much higher percentage of "takes" than vaccination by the so-called "incision" method. This point I (The Journal, Aug. 24, 1918, p. 654) proved rather conclusively as a result of a comparative study of the intradermal and "incision" methods at the time that I devised my original method of intradermal vaccination against smallpox. In my method I injected 0.1 c.c. of virus diluted with equal parts of sterile distilled water. Zinsser also makes note of this point in his most recent textbook of bacteriology (Hiss-Zinsser: A Textbook of Bacteriology, Ed. 5, 1923, p. 899). T. Twyman (<i>J.</i>
Characteristics of patients with multiple episodes of bacterial endocarditis
Authors: M. E. Levison
Journal: JAMA (1970)

The records of 268 patients with bacteriologically confirmed endocarditis who were hospitalized between 1944 and 1967 showed 251 with one episode each and 17 with more than one episode. Of the latter group 14 had two episodes and 3 patients had three episodes each. These patients differed from those with single episodes in the following respects: α-hemolytic streptococcal endocarditis was significantly more frequent, congenital heart disease was significantly more common, and patients with multiple episodes were younger at the time of initial infection. A cure was achieved in 33 of the 37 multiple episodes (89%), which compares favorably with results in patients with single episodes. Relapse occurred in the other four episodes, but cure was achieved on retreatment.
A NEW DOCTRINE ABOUT DRUNKENNESS AND RESPONSIBILITY.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FOOD-STORAGE REFORM.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cytogenetic Findings on Shoe Workers Exposed Long-Term to Benzene
Authors: Berrin Turkel Tunca, Unal Egeli
Journal: Environmental Health Perspectives (1996)

Cytogenetic analysis of peripheral blood lymphocytes was performed to detect cytogenetical alterations in 58 shoe workers (57 male and 1 female) who had been exposed to particular mutagenic or carcinogenic agents and in 20 subjects selected from the general population as a control group.Frequencies of damaged cells, including gaps, breaks, and rearrangements (acentric fragment, deletion, translocations) were scored for both groups.The incidence of chromosomal aberrations (particularly chromatid gaps and breaks) in the study group was significantly higher than in the control group.No effects of smoking were observed and breaks alone were found to be influenced by alcohol consumption.No significant correlation was detected between the working period in the group exposed to benzene and frequency of chromosomal aberrations.Benzene content was determined to be between 0 and 28.5% in eight kinds of glues studied by fractional distillation.Hexane content ranged between 0 and 68.35% using the same method.This study indicated that the content of benzene and hexane in the glues are above normal limits.
1993 INTERIM MEETING OF THE HOUSE OF DELEGATES
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal