tbuckley/cabot-search huggingface dataset:
Extradural haematoma: effect of delayed treatment.
Authors: A D Mendelow, M Z Karmi, K S Paul, G A Fuller, F J Gillingham
Journal: BMJ (1979)

The case records of patients with extradural haematomas treated in the Lothian region during 1951-60 and 1968-77 were analysed to assess the effect of delay in treatment on morbidity and mortality. Delay was defined as the time from deterioration in level of consciousness to surgical evacuation of clot. There were 83 supratentorial extradural haematomas unassociated with intradural clot or contusion. The mean delay in patients who died was 15.7 hours, while in good-quality survivors the mean delay was 1.9 hours. Mortality decreased from 33.3% during 1951-60 to 8.9% during 1968-77. In addition, good recovery without morbidity occurred in 40.7% of patients in the earlier period and 67.9% in the later period. Mean delays from deterioration in level of consciousness to operation were 9.8 and 2.4 hours in the earlier and later periods respectively. The results emphasise the need for immediate operation in patients deteriorating with extradural haematomas. Direct admission of all head-injured patients to a head and spinal injuries unit staffed by neurosurgeons resulted in minimal delay times as well as a reduction in morbidity and mortality.
Manuscripts Approved for JNCI, September 15 to October 15, 1961
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article Manuscripts Approved for JNCI, September 15 to October 15, 1961 Get access JNCI: Journal of the National Cancer Institute, Volume 27, Issue 5, November 1961, Page 1225, https://doi.org/10.1093/jnci/27.5.1225 Published: 01 November 1961
Orthopedic Surgery
Authors: Otto E. Aufranc, Joseph S. Barr, Thornton Brown, Eugene E. Record
Journal: New England Journal of Medicine (1957)

DiagnosisThe reasons for the difficulty frequently encountered in establishing a diagnosis should be obvious from what has been said so far. Not only may many different lesions in remote locations give essentially the same symptoms but also, even when the basic pathologic process is recognized, — for example, degenerative changes in the spine, — there is still the problem of locating the site or sites from which the pain arises. Exploratory operations are occasionally justified just as they are in the abdomen, but unfortunately in the spine, the exposure is limited and even under the best of circumstances, some . . .
GERIATRICS
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of the Mutagens in Cooked Beef
Authors: James S. Felton, Mark G. Knize, Nancy H. Shen, Brian D. Andresen, Leonard F. Bjeldanes, Fred T. Hatch
Journal: Environmental Health Perspectives (1986)

The purification of cooking mutagens depends on the extraordinary sensitivity of the Ames/Salmonella mutagenicity test and its usefulness for tracking the mutagens during the purification steps. Following aqueous/acid (pH 2) extraction of fried ground beef (cooked at 200, 250, or 300 degrees C), XAD-2 column adsorption and elution with acetone, and acidic and basic liquid/liquid extractions, the samples are separated into six distinct peaks with preparative reverse-phase HPLC. A total of nine distinct mutagens can be separated after two additional HPLC steps. These compounds fall into a class of compounds called aminoimidazoazaarenes (AIAs). The majority of the mutagenic activity is made up of MeIQx1 (m/z 213, C11H11N5), DiMeIQx (m/z 227, C12H13N5), trimethylimidazopyridine (TMIP) (m/z 176, C9H12N4) and phenylimidazopyridine (PhIP) (m/z 224, C13H12N4). Smaller contributions are from IQ (m/z 198, C11H10N4), MeIQ (m/z 213, C12H12N4), a nonpolar peak containing oxygen and two unidentified trace polar mutagens. Mass estimates (per kilogram uncooked beef) include: 15 micrograms for PhIP, 1.0 micrograms for MeIQx, 0.5 microgram for DiMeIQx, and 0.02 microgram for IQ. Because of the uncoupling of mutagenic and carcinogenic potencies of these aromatic amines, the PhIP, which contributes the highest mass content to the cooked meat, but has the lowest mutagenic potency, might ultimately make a significant contribution to the carcinogenicity.
Oyster Fanciers
Authors: Thomas F. Paine
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The delightful front cover of the Jan 20 issue ofThe Journalshowing the oyster fanciers brings to mind John Gay's 18th century verse: The man had sure a palate covered o'er With brass or steel, that on the rocky shore First broke the cozy oyster's pearly coat And risked the living morsel down his throat.
Updated results from NABTT CNS consortium studies in primary CNS lymphoma
Authors: T. Batchelor, S. Grossman, K. Carson, J. Fisher
Journal: Journal of Clinical Oncology (2004)

1519 Background: Optimal therapy for patients with newly diagnosed PCNSL has not been defined. Methods: From 6/98–12/99, The New Approaches to Brain Tumor Therapy (NABTT) CNS consortium conducted a phase 2 trial of high dose methotrexate (MTX) without radiation (J Clin Oncol 2003; 21:1044–1049). We now report longer-term follow-up data from this study as well as preliminary results from our ongoing phase 2 study. Results: In the initial study, 25 patients with a median age of 60 and median KPS of 80 were treated with MTX at an intravenous (i.v.) dose of 8 g/m2 for up to 8 induction cycles every 14 days, 2 consolidation cycles every 14 days and 11 maintenance cycles every 28 days. There were 12/23 (52%) complete responses (CR); 5/23 (22%) partial responses; 1/23 (4%) stable disease and 5/23 (22%) progressions during treatment. In the 12 patients who achieved CR the median number of cycles to CR was 6. The median progression free survival was 12.8 months and median overall survival has not been reached at 47.6 months. Based on these promising results a second study was initiated combining MTX (8 g/m2 i.v. every 14 days) with thio-TEPA (2 mg/kg i.v. every 14 days). The first 3 patients treated with this regimen each achieved a CR after a median of 4 cycles of chemotherapy and remain in CR at 280, 313, and 340 days. Myelosuppression was prohibitive and the thio-TEPA dose was reduced to 2 mg/kg every 28 days for subsequent patients. Conclusions: Overall survival with high dose MTX monotherapy compares favorably with results reported with more toxic, chemotherapy plus radiation strategies. Early results from the NABTT protocol using MTX and thio-TEPA suggest that this combination might reduce the time to CR and increase the percentage of patients achieving CR. No significant financial relationships to disclose.
Fluorescence in the Tapetum of the Cat's Eye
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Data in the Abstract
Journal: JAMA Network Open (2020)

Paul Dietze, PhD; Marianne Jauncey, MPH (Hons); Allison Salmon, PhD; Mohammadreza Mohebbi, PhD; Julie Latimer, BN (Hons); Ingrid van Beek, MD; Colette McGrath, MHM; Debra Kerr, PhD
Sexual transmission efficiency of hepatitis B virus and human immunodeficiency virus among homosexual men
Authors: L. A. Kingsley
Journal: JAMA (1990)

The relative sexual transmission efficiency of hepatitis B virus (HBV) and human immunodeficiency virus type 1 (HIV-1) was investigated by a prospective study of homosexual men in Pittsburgh, Pa, from the Multicenter AIDS Cohort Study. During the 30-month follow-up, 19.8% and 7.8% of the initially seronegative HBV and HIV-1 groups were estimated to seroconvert to HBV and HIV-1, respectively. The significantly higher cumulative HBV seroconversion rate occurred despite a much lower prevalence of hepatitis B carriers (7% were hepatitis B surface antigen positive) compared with HIV-1 carriers (22% were HIV-1 antibody positive). The sexual exposure profile of HBV and HIV-1 seroconverters was similar during the 6 months prior to seroconversion, supporting the link between anal intercourse and acquisition of either infection. However, insertive, not receptive, anal intercourse was the major risk factor identified for HBV seroconversion, suggesting that transurethral exposure is an important mode of transmission. These data suggest that HBV is transmitted 8.6-fold more efficiently than HIV-1 among homosexual men studied and underscore the benefits of both HBV immunization and use of condoms during intercourse to prevent HBV infection. (<i>JAMA</i>. 1990;264:230-234)
Book Review Endocrine Medicine . By William Engelbach. Vol. 1, General Considerations; Vol. 2, The Infantile Endocrinopathies — The Juvenile Endocrinopathies; Vol. 3, The Adolescent Endocrinopathies — The Adult Endocrinopathies; Vol. 4, Bibliography. Index. Published by Charles C. Thomas. Price $35.00.
Journal: New England Journal of Medicine (1933)
SP-A deficiency in primate model of bronchopulmonary dysplasia with infection. In situ mRNA and immunostains.
Authors: J J Coalson, R J King, F Yang, V Winter, J A Whitsett, R A Delemos, S R Seidner
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The surfactant protein secretory cells in airway and alveolar epithelium were studied in premature baboons with bronchopulmonary dysplasia and superimposed infection. PRN animals were delivered by hysterotomy at 140 d gestational age and ventilated on clinically appropriate oxygen for a 16-d experimental period. To assess 0 time and sacrifice time gestational parameters, 140 and 156 d were studied. BPD animals were delivered at 140 d and ventilated with positive-pressure ventilation and an FIO2 of 1.0 for 11 d followed by 5 d of oxygen sufficient to maintain PAO2 at 40 to 50 mm Hg. BPD-infected animals were comparably ventilated and treated like the BPD group except that 10(8) E. coli organisms were endotracheally instilled on Day 11. In situ hybridization studies for mRNA expression of SP-A, SP-B, and SP-C revealed that an SP-A mRNA deficiency, present at 140 d, persisted in the BPD and BPD-infected groups, whereas SP-A mRNA was abundant in PRN and 156 d gestation control groups. SP-B and SP-C mRNA expression in the two hyperoxically injured groups was particularly extensive in cells around peribronchiolar and perivasicular sites. Immunostaining with SP-A, SP-B, and SP-C antibodies showed variable staining patterns. The study clearly demonstrates that a deficiency of SP-A mRNA expression persists in chronic lung injury and that variable protein staining patterns are manifested depending upon the underlying pathology.
Causes of Angina Morbidity among Workers of the Silk Industry in Uzbeck, USSR
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Immunotherapy
Authors: David Plotkin
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The discussion of BCG vaccine by Hersh et al (235:646, 1976) is appropriately subtitled "Potential, Practical Considerations, and Precautions in Human Cancer Immunotherapy." However, despite occasional conservatism in the interpretation of results and advising therapy, for the most part, the tone and substance of the article is disturbingly inconsistent, precipitous, and—we strongly suspect—misleading to readers unsophisticated in this field. The authors conclude that there is sufficient evidence that BCG immunotherapy is<i>indicated</i>in acute myelocytic leukemia (ML) based on the following: (1) three trials, which the authors term controversial, using different types of BCG administered by different techniques with and without leukemic cells (these preliminary data should not be used to mandate any form of therapy), (2) data from a single study using methanol extractable residue (MER) that appears to prolong remission duration in a preliminary report (MER's parallel effects to live BCG are as yet undetermined),
Pregnancy-associated deaths due to AIDS in the United States
Authors: L. M. Koonin
Journal: JAMA (1989)

From 1981 to 1988, eighty percent of all women with the acquired immunodeficiency syndrome (AIDS) reported to the Centers for Disease Control were of reproductive age. Six pregnancy-associated deaths due to AIDS in this country have been reported in the medical literature. We identified 20 unpublished cases of women who died of AIDS during or within one year after termination of pregnancy. Analysis showed that these women were mostly black or Hispanic, half were intravenous drug abusers, and most died of<i>Pneumocystis carinii</i>pneumonia. Each pregnancy had an obstetric complication, primarily preterm delivery. The interval between diagnosis of AIDS and the death of these women ranged from one day to 15 months, with a mean interval of 113 days. Multiple reporting sources increased case detection and should be used for future investigations. Prospective case-control studies are needed to determine any further relationship between pregnancy complications and AIDS. (<i>JAMA</i>1989;261:1306-1309)
2018 BCVS Honorees: Louis N. and Arnold M. Katz Basic Research Prize
Authors: Arnold Katz Basic, Louis Bcvs, Arnold Katz, Young Investigators, Matthew Brody, San Matt
Journal: Circulation Research (2019)

He underwent his doctoral training in the laboratory of Dr Youngsook Lee at the University of Wisconsin-Madison, where he studied novel genetic and molecular determinants of dilated cardiomyopathy
THE ANÆSTHETIC INVESTIGATION OF THE BRITISH MEDICAL ASSOCIATION IN 1892.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXPERIMENTAL INQUIRY INTO THE EFFECTS OF INJECTING PUS INTO THE VEINS OF ANIMALS
Authors: J. S. Gamgee
Journal: BMJ (1854)

t be induced by m cs inth v m g no specifi or ponous qualities.From experments which have been now varied in a thou- sand ys, ad most unnecessily repeated, it has been proved beyond a doubt that the syphtc pon may re- m in contact with an abraded surface or may be inserted beeath the cuticle, and allowed to remain there for three, four, oreven five days,and no absorption mayoccur.If,during this time, an inflammatory action is set up, which is incom- patible with specific adhesive inflammation, no general infection will follow.If, for instance, the part is made to slough by the application of caustic, as soon as the slough separates, a simple sore alone will remain.From this, it is
Reply
Authors: G.M. Murphy
Journal: British Journal of Dermatology (2000)

Journal Article Reply Get access G.M. Murphy G.M. Murphy Photobiology Unit, Beaumont and Mater Misericordiae Hospitals, Dublin 7, Ireland E‐mail: gillian@iol.ie Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 4, 1 April 2000, Page 827, https://doi.org/10.1046/j.1365-2133.2000.03443.x Published: 01 April 2000
Beating the knowledge and technology explosion
Authors: M. H. Dykes
Journal: JAMA (1981)

SINCE World War II, there has been a phenomenal growth in knowledge and technology. Our profession has shared in this growth,<sup>1-5</sup>but with serious strain placed on all of us, from premedical students to expert physicians. Several approaches to medical education would reduce the strain on physicians while preparing them to function with confidence in their expertise and with time to enjoy the fruits of their labors. I will not discuss noneducational solutions such as reduced paperwork, expanded roles for physician's assistants, and improved efficiency and validity of health-regulatory agencies. <h3>Increasing Subspecialization</h3> Godber<sup>6</sup>has noted that increasing specialization and subdivision have been necessary to "cope with the rapid advance of biomedical science." He raises the issue of how far specialization should go to provide care the public can understand, consent to, and benefit from, but does not provide criteria for making the necessaryjudgments. He indirectly states that subdivision
The Advantages and Limitations of an in Vivo Test System for Investigating the Cytotoxicity and Fibrogenicity of Fibrous Dusts
Authors: S. E. Sykes, A. Morgan, S. R. Moores, W. Davison, J. Beck, A. Holmes
Journal: Environmental Health Perspectives (1983)

The acute response of the rat lung to a range of fibrous materials has been investigated by bronchopulmonary lavage, at dose levels of 0.5 and 1.0 mg, 1 and 7 days after their administration by intratracheal instillation. The materials chosen for study included UICC chrysotile A, amosite, crocidolite and anthophyllite, and samples of S. African "long" amosite and glass fiber. In addition, the subacute response to 1, 2 and 3 mg of chrysotile and amosite has been studied at 50 and 100 days after instillation. In the acute phase at 1 day after instillation, the response to chrysotile was greater than that to any of the other materials, but by 7 days there was no gradation in the response to different dusts. In the subacute phase, cell recoveries were low, and it was not possible to assess the long-term cytotoxic or fibrogenic effects of amosite and chrysotile by analyses of lung washes, even though biochemical and histological methods indicated gross changes in lung pathology.
Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affair
Authors: K. Schwartz
Journal: Journal of Clinical Investigation (2003)

It has long been noted that while patients with familial hypertrophic cardiomyopathy due to cardiac troponin T (cTnT) mutations often suffer sudden cardiac death, they do not develop significant ventricular hypertrophy, suggesting that a distinct cellular mechanism apart from alterations in myocardial contractility is responsible. A new study has revealed that a single missense mutation in cTnT causes a striking disruption to energy metabolism, leading to cardiomyopathy.
Index of Authors&lt;subtitle&gt;Volume 18&lt;/subtitle&gt;
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Index of Authors: Volume 18 Get access JNCI: Journal of the National Cancer Institute, Volume 18, Issue 6, June 1957, Pages 865–866, https://doi.org/10.1093/jnci/18.6.865 Published: 01 June 1957
Reply to E. Jason Abel Letter to the Editor re: Lorenzo Marconi, Saeed Dabestani, Thomas B. Lam, et al. Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy. Eur Urol 2016;69:660–73
Authors: Lorenzo Marconi, Thomas B. Lam, Axel Bex, Börje Ljungberg, Alessandro Volpe
Journal: European Urology (2016)
1231 STATE BOARD STATISTICS FOR 1920
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal