tbuckley/cabot-search huggingface dataset:
Abstract 2047: The interaction of ZSCAN4 with TRF1: Effects on regulation of telomere elongation in cancer cells
Authors: Kyungwoo Lee, Lauren Gollahon
Journal: Cancer Research (2012)

Abstract Telomeres are repetitive sequences at the ends of chromosomes protected by DNA binding proteins of shelterin complex that form capping structures. One of these proteins, TRF1, plays a role in the regulation of telomere length through its interaction with other proteins in the shelterin complex. High levels of TRF1 expression have been shown to accelerate telomere shortening, whereas dominant-negative inhibition of TRF1 leads to telomere elongation. Recently, the newly identified Zinc finger and SCAN domain containing4 gene (ZSCAN4) plays a key role in genomic stability by regulating telomere elongation and was shown to co-localize with TRF1 foci. Here, we show that ZSCAN4 is a TRF1 association protein. We hypothesized that ZSCAN4 would affect levels of TRF1expression and correspondingly control the function of TRF1 through negative regulation and dominant-negative inhibition. Using Co-immunoprecipitation, we demonstrate that ZSCAN4 binds with TRF1 in vitro. Pull-down assay results show that ZSCAN4 directly interacts with TRF1. Using PCR mutagenesis, we have identified the binding site between ZSCAN4 and TRF1. Furthermore, over-expression of ZSCAN4 expression acts as an activator of telomere elongation. The ZSCAN4 mediated cooperative binding of TRF1 to telomeric DNA has important implications for understanding the mechanism of telomere extension. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2047. doi:1538-7445.AM2012-2047
The Morbid Histology of the Spinal Cord in Five Cases of Insanity
Authors: R. Atkins
Journal: BMJ (1878)

MiLrch 2Sth.Marked dulness Was found in the rght flank March 30th.He had another rigor, commencing at 9.45 AM.,and lasting thirty minutes., Temperature i15.2 deg. at II.15 A. M.; pulse r20o-9 P.M.He was sweating profusely.Temperature 96.6 deg.The iodide of potassium was omitted, and five grains of quinine ordered in pills thrice daily.April 2nd.The right base was dull from the angle of the scapula.The respiratory sounds were rather feeble.The lett base was rather flat on percussion.Pulse 92; evening temperature I00.2 deg.April 17th.There was not much change since the last note.He was made an out-patient at his own request.April 20th.On the afternoon of this day, he was seized at home with severe pain in the abdomen.He vomited frequently; and, when seen by a medical man, be was in a state of collapse.He died the same evening.NECROPSY.-Apost mortenm examination was obtained with diffi- culty.Leave was only given to open the abdomen.On cutting through the abdominal wall, the sac of an enormous hydatid, full of fluid and vesicles of various sizes, was found.The sac had evidently undergone suppuration.The diaphragm was cut through, and recent pericarditis discovered.The wall of the parent hydatid cyst was carti- laginous in consistence, and quite a quarter of an inch thick.No cause could be discovered for the needle of the aspirator not having reached the sac.REMARKS.-This case was a very puzzling one.The history of it was certainly in favour of its being one of hydatids, and yet the three
Update in Infectious Diseases
Authors: John G. Bartlett
Journal: Annals of Internal Medicine (2001)

Letters3 July 2001Update in Infectious DiseasesJohn G. Bartlett, MDJohn G. Bartlett, MDJohns Hopkins University; Baltimore, MD 21287-0003 (Bartlett)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-1-200107030-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Lodato makes a good point regarding the contribution of antibiotic abuse in animals to antibiotic resistance and antibiotic-resistant infections in people. Agricultural antibiotic use seems to have been particularly important in vancomycin resistance in Europe (but not the United States), as well as fluoroquinolone resistance in Salmonella species and Campylobacter jejuni. Nevertheless, to keep perspective, the overuse of antibiotics in patients, particularly those with viral respiratory infections, and extensive use of broad-spectrum antibiotics in hospitals probably account for the lion's share of our current dilemma. Having said this, I acknowledge that the publication by Mølbak and colleagues ...Reference1. Mølbak K, Baggesen D, Aarestrup F, Ebbesen J, Engberg J, Frydendahl K, et al . An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype typhimurium DT104. N Engl J Med. 1999;341:1420-5. [PMID: 10547404] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Johns Hopkins University; Baltimore, MD 21287-0003 (Bartlett) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUpdate in Infectious Diseases John G. Bartlett Update in Infectious Diseases Robert J. Lodato Metrics 3 July 2001Volume 135, Issue 1Page: 64KeywordsAntibiotic resistanceAntibioticsCampylobacter jejuniInfectious diseasesSalmonellaUpper respiratory tract infectionsVancomycin resistance ePublished: 3 July 2001 Issue Published: 3 July 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
INTESTINAL LIPODYSTROPHY
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Diseases of Egypt.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plague Increase in Western US
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A New Skeletal Muscle Relaxant
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rare Cases in Midwifery
Authors: E. Copeman
Journal: BMJ (1862)

CASE XIII.Rupture of Uterus.In the year 184i1, I was summoned by special train at 2 A.M. to a lady, whom I found on my arrival to have been dead nearly an hour.The medical gentlemen present gave me the following history of this melancholy case. Mrs.was quite well at 8 rP., playing with her children in her drawing-room; but, being in hourly ex- pectation of her labour, she told them not to make her laugh so much, as it made her uncomfortable.Shortly after this, she suddenly felt a very powerful and painful moveineit of the child, became very faint, and could only just manage to get to her bedroom before she was violently sick, having at the same time a good deal of pain in the body.The gentleman who was engaged to attend her, was immediately summoned, and, finding her so faint, very naturally supposed there was huamor- rhage, especially as she had suffered from hemorrhage in some of her previous confinements.There was none, however, externally; but on examining, he thought he felt the placenta, and summoned to his assistance a friend and former medical attendant of the patient.When lie arrived, he saw at once that the case presented some unusual difficulty; and a message was im- mediately despatched for me to come without delay.Before I could arrive, matters had become so urgent, that another gentleman, near at hand, was summoned, who thought she was labouring under some unaccount- able shock, and that the presentation was a breech, and not placenta.During this time, no serious hbemorrhage had occurred, no clots, only bloody water.In an ex- amination, the membranes were ruptured, but very little liquor amnii escaped.She was all this time very faint; and, as stimulants failed to remove the exhaustion under which she laboured, it was thought better to deliver.
Supportive management of the patient with malignant brain tumor
Authors: C. B. Wilson
Journal: JAMA (1980)

Primary brain tumors constitute nearly 10% of nontraumatic neurological disease. The incidence of metastatic tumors is increasing and will continue to increase as therapeutic improvements prolong survival. Sooner or later, most of these patients will have major neurological disabilities. The management of the most common of these disabilities, including the care of bedridden or comatose patients, is discussed, along with consideration of the role of the family in caring for the patient's physical and psychological needs. (<i>JAMA</i>244:1249-1251, 1980)
For Secretaries...
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The future of general internal medicine. Council on Long Range Planning and Development in Cooperation with the American College of Physicians, the American Society of Internal Medicine, and the Society of General Internal Medicine
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calculated risk of sports fatalities
Authors: K. S. Clarke
Journal: JAMA (1966)

A sports fatality is news with impact across the nation. As school administrators and physicians attest, news of each fatality perpetuates a prevailing anxiety among educators and parents: Are our youth accepting undue risks by going out for sports? Charged as it is with emotion, this question of calculated risk receives treatment more expeditious than judicious. Critics and enthusiasts alike tend to limit their calculated-risk rationale to fatalities, to overestimate the utility of a fatality report as a sports-risk figure, and thus to overinterpret the same data to support their respective positions. This basis for decisiveness contributes neither to an understanding of undue risk nor to quiet evaluation of the fatalities that occur. <h3>Calculated Risk.—</h3> Calculated risk is an assessment of the hazards in the sports being offered relative to the sports' purported benefits. Subsequent conclusions underly decisions affecting the participation of typical and atypical candidates. However, we do not
Health status of refugees from Vietnam, Laos, and Cambodia
Authors: A. Catanzaro
Journal: JAMA (1982)

More than 0.5 million refugees from Southeast Asia have immigrated to the United States. We undertook a prospective evaluation of 709 refugees within two months of their resettlement in San Diego. The sample included 164 Vietnamese, 356 Cambodians, 139 Laotians, and 50 Hmong. The prevalence of abnormalities was high: intestinal parasites, 61%; positive tuberculin test (PPD) results, 55%; anemia, 37%; hepatitis B antigenemia, 14%; and abnormal VDRL test results, 12%. Except for hepatitis, significant differences were noted among the Vietnamese, Cambodian, Laotian, and Hmong subjects on each of these health status indicators. The refugee population should not be considered a homogeneous group of Indochinese, particularly by those responsible for their health care. (<i>JAMA</i>1982;247:1303-1308)
Oral Antibiotic Therapy For Serious Infections
Authors: A. Smith
Journal: Annual Review of Medicine (1988)

After a pathogen has been identified and the antibiotic susceptibility determined, parenteral antibiotic administration can be replaced by the oral route for certain patients with meningitis, brain abscess, endocarditis, and skeletal infections. Antibiotics should be administered with the stomach empty and accompanied by 3 ml/kg of water. Direct instillation into the lumen of the small intestine may be advantageous with selected patients. Documenting adequate antibiotic absorption and ensuring compliance are essential to efficacious therapy.
Toll-Free Number for Locating Certified Mammography Facilities
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neonatal outcome in planned v unplanned out-of-hospital births in Kentucky
Authors: M. W. Hinds
Journal: JAMA (1985)

We conducted a survey of 1,064 out-of-hospital Kentucky births during 1981 to 1983 in order to classify each by planning status (planned or unplanned to occur out of hospital) and attendant. Among the 809 births for which we obtained information, 575 (71.1%) were planned. We examined birth outcome by low birth weight (LBW) and neonatal mortality (NM). Compared with planned births, unplanned births were associated with increased risk of LBW (odds ratio=6.6; 95% confidence limits [CL], 3.9 to 11.2, adjusted for maternal age). Furthermore, after adjusting for maternal age and parity, LBW births occurred at less than expected frequency among planned births (observed to expected [O:E] ratio=0.48; 95% CL, 0.29 to 0.73), but at greater than expected frequency among unplanned births (O:E ratio=2.9; 95% CL, 2.2 to 3.8). A similar, but nonsignificant, trend was seen for NM and NM was much greater in the unplanned group (72.7 per 1,000 live births) than in the planned group (3.5 per 1,000). (<i>JAMA</i>1985;253:1578-1582)
Corticotherapy of Patients with Cirrhotic Ascites: Based on a Series of 100 Patients Followed-Up for at Least Two Years
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Test of the Doman-Delacato rationale with retarded readers
Authors: M. P. Robbins
Journal: JAMA (1967)

An empirical test of the central concept and treatment efficacy of the Doman-Delacato rationale was implemented by investigating the influence of a program based on the theory of neurological organization on the reading development of retarded readers. The study employed a traditional control group and a nonspecific program, thought to simulate the placebo effect. The results failed to confirm the validity of the rationale— suggesting that verifiable, empirical evidence from carefully controlled studies is needed if the rationale is to be taken seriously by the scientific community.