tbuckley/cabot-search huggingface dataset:
New Prognostic Score Based on Treatment Outcome of Patients With Relapsed Hodgkin’s Lymphoma Registered in the Database of the German Hodgkin’s Lymphoma Study Group
Authors: Andreas Josting, Jeremy Franklin, Michael May, Peter Koch, Maria K. Beykirch, Juergen Heinz, Christian Rudolph, Volker Diehl, Andreas Engert
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To evaluate salvage treatment outcome of patients with relapsed Hodgkin’s disease (HD) and to distinguish different risk groups using identified prognostic factors. PATIENTS AND METHODS: From 4,754 patients registered in the German Hodgkin’s Lymphoma Study Group (GHSG) database between 1988 and 1999, 422 patients with early (n = 170) or late (n = 252) relapsed HD were identified. One hundred seven patients (25%) relapsed after radiotherapy (RT) for early stages, 133 patients (32%) after combined-modality therapy for intermediate stages, and 182 patients (43%) after chemotherapy (CT) and RT to initial bulky disease or residual lymphoma for advanced stages. At relapse, characteristics of these 422 patients (median age, 38 years; range, 17 to 77) were stage III/IV, 45%; B symptoms, 24%; elevated erythrocyte sedimentation rate, 29%; anemia, 13%; and Karnofsky performance score, less than 90 in 13%. At first relapse, salvage treatment was RT in 13%, CT in 54%, and high-dose chemotherapy (HDCT) with autologous stem-cell transplantation (ASCT) in 33%. RESULTS: Median follow-up time after relapse was 45 months. Freedom from second failure (FF2F) and overall survival (OS) were 81% and 89% for relapse after RT, 33% and 46% for early relapse after CT, and 43% and 71% for late relapse after CT, respectively. In multivariate analysis, independent risk factors were time to relapse, clinical stage at relapse, and anemia at relapse. Four subgroups with significantly different FF2F and OS were identified. The prognostic score was predictive for patients who relapsed after RT, CT with conventional CT salvage, and CT with HDCT/ASCT. CONCLUSION: In the GHSG database, time to relapse and clinical stage and anemia at relapse are relevant factors and can be used to form a prognostic score for HD patients at relapse.
A Retrospective Evaluation of COMPACT Predictions of the Outcome of NTP Rodent Carcinogenicity Testing
Authors: David F. V. Lewis, Costas Ioannides, Dennis V. Parke
Journal: Environmental Health Perspectives (1995)

The carcinogenic potentials of 40 National Toxicology Program chemicals previously predicted by Computer Optimised Molecular Parametric Analysis for Chemical Toxicity (COMPACT), based on the identification of potential substrates of cytochromes P4501A and 2E (CYP1A and CYP2E), have been compared with new rodent carcinogenicity results. The COMPACT predictions have also been compared with published Ames mutagenicity data and with our own Hazardexpert predictions for carcinogenicity. Concordance evaluations between rodent carcinogenicity (1/4 segments positive) and predictions by COMPACT or Hazardexpert were 64% for COMPACT (CYP1A only), 72% for COMPACT (CYP1A plus CYP2E), 70% for Hazardexpert alone, and 86% for COMPACT (CYP1A plus CYP2E) plus Hazardexpert. Sensitivities of the predictions were for COMPACT, 75%; Hazardexpert, 60%; and Ames, 54%. Positive predictivities were for COMPACT, 75%; Hazardexpert, 78%; and Ames 81%. Negative predictivites were for COMPACT, 62%; Hazardexpert, 52%; and Ames, 42%.
Vaccination Coverage of 2-Year-Old Children— United States, 1993
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Concerning Squirrels.
Authors: E. H. Smith
Journal: JAMA (1898)

Santa Clara, Cal., Feb. 19, 1898. <h3>To the Editor:</h3> —I wish to add a few observations and facts, regarding squirrels, gathered about the inhabitants of the trees of southwestern Michigan. During the breeding season squirrels like other quadrupeds are very apt to fight. During this time the males battle violently. Their mode of battle is to chase each other until a favorable opportunity presents itself for one or the other to dart beneath the flank of his adversary and bite off his testicles. Sometimes both males share the same fate at the same time. The chisel-shaped teeth together with the ability to take a large round object into the mouth of the squirrel, makes it an easy matter for this animal to maim his adversary in this way almost instantly. Instead of gray or fox squirrels castrating their own male young the credit must more often be given the agile
Archives of Environmental Health, Chicago
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Debbie's dying: mercy killing and the good death
Authors: K L Vaux
Journal: JAMA (1988)

Vaux, a consultant in medical ethics, reflects on the issue of physician-administered euthanasia raised in JAMA's controversial article, "It's over, Debbie" (1988 Jan 8; 259(2): 272). He asks if the death of the young terminal cancer patient was really a case of morally acceptable double-effect euthanasia, resulting from the anonymous resident's use of morphine primarily to relieve her pain with death as an unfortunate side effect. Vaux argues that, while the cardinal purpose of medicine is "to save and sustain life and never intentionally to harm or kill," and while euthanasia must be proscribed in principle, "in exceptional cases it may be abided in deed."
VACCINATION AGAINST RICKETTSIAL INFECTIONS
Authors: P. W. C.
Journal: Annals of Internal Medicine (1942)

Editorial1 February 1942VACCINATION AGAINST RICKETTSIAL INFECTIONSP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-2-366 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo types of rickettsial infections are associated with so high a mortality and (at least, at some times) so high a morbidity that effective preventive measures are of great practical importance. These are epidemic ("Old World") typhus fever, and the Rocky Mountain spotted fever.Spotted fever is conveyed to man by the bite of the wood tick. Man does not constitute an essential link in the life cycle of the infection. The natural reservoir of the virus is the tick, in which it passes from one generation to the next through the egg, and probably also various wild mammals on...1 PARKER RP: Rocky Mountain spotted fever. Results of fifteen years prophylactic vaccination, Am. Jr. Trop. Med., 1941, xxi, 369-384. CrossrefGoogle Scholar2 DYER RE: The control of typhus fever, Am. Jr. Trop. Med., 1941, xxi, 163-184. CrossrefGoogle Scholar3 LAIGRET J: La vaccination contre le typhus exanthématique par la vaccine enrobé de l'institut Pasteur de Tunis, Arch. Inst. Pasteur de Tunis, 1937, xxvi, 454-623. Google Scholar4 CASTANEDA MR: Experimental pneumonia produced by typhus rickettsiae, Am. Jr. Path., 1939, xv, 467-475. Google Scholar5 ZINSSERPLOTZENDERS HHJF: Mass production of vaccine against typhus fever of the European type, Science, 1940, xci, 51-52. CrossrefGoogle Scholar6 CoxBELL HREJ: Epidemic and endemic typhus: protective value for guinea pigs of vaccines prepared from infected tissues of the developing chick embryo, Pub. Health Rep., 1940, lv, 110-115. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1942Volume 16, Issue 2Page: 366-369KeywordsFeversMorbidityMortalityRocky Mountain spotted feverTicksTyphus ePublished: 1 December 2008 Issue Published: 1 February 1942 PDF downloadLoading ...
A New MHC Locus that Influences Class I Peptide Presentation
Authors: Joel D. Taurog, Kirsten Fischer Lindahl, Robert E. Hammer, Clive A. Slaughter, Shanna D. Maika, Ming Zhou, Derry C. Roopenian, Gregory J. Christianson, Simon J. Gaskell, Richard C. Jones, Robert Bordoli, Hidde L. Ploegh, Begoña Galocha, Scott G. Summerfield
Journal: Immunity (1999)
Omitted evidence?
Authors: Stephen I Black
Journal: BMJ (2005)

Endovascular repair is not worse than open repair of abdominal aortic aneurysmsEditor-The title and interpretation of the EVAR trial results in the POEM are misleading and incorrect. 1Mortality figures were quoted both as aneurysm related and all cause deaths.The 30 day mortality was 1.7% in the EVAR group, which is significantly lower than 4.7% in the open repair group.Surprisingly, the POEM somehow interpreted 30 day mortality to be less than 1% for both groups, which is clearly an error.The confidence intervals (odds ratio 0.35, 95% confidence interval 0.16 to 0.77, P = 0.009) make type I error unlikely.If preintervention deaths are added to the figures 30 day mortality was calculated at 3.5% for endovascular repair and 7.1% for open surgery. 2 The advantage of endovascular repair is sustained at four years, with 4% aneurysm related deaths in the EVAR group compared with 7% in the open repair group.This confers a 3% absolute reduction in aneurysm related mortality.The all cause mortality rate was comparable in both groups at four years.Endovascular repair offers a 30 day lower risk treatment compared with open surgery in patients who are medically fit with an abdominal aortic aneurysm.Compared with open repair, endovascular repair offers no advantage with respect to all cause mortality and health related quality of life; and is more expensive; however, it confers a 3% improved aneurysm related survival which persists at four years.The POEM's message that endovascular repair is worse than open repair is inaccurate and not evidence based.
Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage- CSF, interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by IL-1
Authors: L Lanfrancone, D Boraschi, P Ghiara, B Falini, F Grignani, G Peri, A Mantovani, PG Pelicci
Journal: Blood (1992)
BOOK REVIEWS
Authors: D. A. FILIPPA
Journal: JNCI Journal of the National Cancer Institute (1988)

BOOK REVIEWS Get access Malignant Lymphoma. Costan W. Berard, Ronald F. Dorfman Nathan Kaufman, eds. Baltimore, MD: Williams & Wilkins 1987, 280 pp. $63.50. DANIEL A. FILIPPA DANIEL A. FILIPPA Memorial Sloan-Kettering Cancer Center1275 New York Ave. New York, NY 10021 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 5, 4 May 1988, Pages 374–375, https://doi.org/10.1093/jnci/80.5.374 Published: 04 May 1988
Abstract 772: MicroRNA regulatory networks: Concomitant <i>in situ</i> detection of microRNA, mRNA and protein in cancer samples
Authors: Boye Schnack Nielsen
Journal: Cancer Research (2019)

Abstract The canonical mode of action of microRNAs involves the binding to the 3'UTR of mRNAs thereby mediating repression of protein synthesis. MicroRNAs comprise an interesting new group of cancer biomarkers and may also be therapeutic targets in cancer and other diseases using antisense oligos (ASO). The visualization of potential molecular dynamics between a microRNA, its target mRNA and the effect of protein expression can be facilitated by combined detection in tissue sections. MicroRNAs, as well as ASOs, can be detected in tissue sections or cultured cells by in situ hybridization (ISH) using LNA probes. We have developed a novel ISH assay for microRNA detection with improved sensitivity and signal-to-noise that can be used with any LNA probe on both FFPE and frozen sections. The assay is based on double-labeled LNA™ probes and detection can be either fluorescence or chromogenic staining. We have combined the fluorescence assay with immunofluorescence, for double and triple staining. We also combined the microRNA ISH assay with mRNA in situ hybridization using the highly specific RNAscope probes. We show a variety of combinations, including examples of combined staining of microRNA-17, IL-1beta mRNA or TNF-alpha mRNA, and cytokeratin proteins in automated triple staining procedures of colon cancer samples. The focal expression of IL-1beta mRNA or TNF-alpha mRNA and the loss of microRNA-17 at the invasive front involving inflammatory cells and budding cancer cells is discussed. Citation Format: Boye Schnack Nielsen. MicroRNA regulatory networks: Concomitant in situ detection of microRNA, mRNA and protein in cancer samples [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 772.
Arterial Wall Changes In Chronic Cerebrovasospasm: In Vitro And In Vivo Pharmacological Evidence
Authors: J. Bevan
Journal: The Annual Review of Pharmacology and Toxicology (1988)

Due to the massive data sets available for drug candidates, modern drug discovery has advanced to the big data era. Central to this shift is the development of artificial intelligence approaches to implementing innovative modeling based on the dynamic, ...Read More
A prospective study of exercise and incidence of diabetes among US male physicians
Authors: J. E. Manson
Journal: JAMA (1992)

<h3>Objective.</h3> —To examine prospectively the association between regular exercise and the subsequent development of non—insulin-dependent diabetes mellitus (NIDDM). <h3>Design.</h3> —Prospective cohort study including 5 years of follow-up. <h3>Participants.</h3> —21 271 US male physicians participating in the Physicians' Health Study, aged 40 to 84 years and free of diagnosed diabetes mellitus, myocardial infarction, cerebrovascular disease, and cancer at baseline. Morbidity follow-up was 99.7% complete. <h3>Main Outcome Measure.</h3> —Incidence of NIDDM. <h3>Results.</h3> —At baseline, information was obtained about frequency of vigorous exercise and other risk indicators. During 105141 person-years of follow-up, 285 new cases of NIDDM were reported. The age-adjusted incidence of NIDDM ranged from 369 cases per 100 000 person-years in men who engaged in vigorous exercise less than once weekly to 214 cases per 100000 person-years in those exercising at least five times per week (<i>P</i>, trend, &lt;.001). Men who exercised at least once per week had an age-adjusted relative risk (RR) of NIDDM of 0.64 (95% Cl, 0.51 to 0.82;<i>P</i>=.0003) compared with those who exercised less frequently. The age-adjusted RR of NIDDM decreased with increasing frequency of exercise: 0.77 for once weekly, 0.62 for two to four times per week, and 0.58 for five or more times per week (<i>P</i>, trend,.0002). A significant reduction in risk of NIDDM persisted after adjustment for both age and body-mass index: RR, 0.71 (95% Cl, 0.56 to 0.91;<i>P</i>=.006) for at least once per week compared with less than once weekly, and<i>P</i>, trend,.009, for increasing frequency of exercise. Further control for smoking, hypertension, and other coronary risk factors did not materially alter these associations. The inverse relation of exercise to risk of NIDDM was particularly pronounced among overweight men. <h3>Conclusions.</h3> —Exercise appears to reduce the development of NIDDM even after adjusting for body-mass index. Increased physical activity may be a promising approach to the primary prevention of NIDDM. (<i>JAMA</i>. 1992;268:63-67)
How to Stay Young.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings7 August 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-3-200108070-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Alternative MedicineAlternative and Complementary Treatment in Neurologic IllnessMI Weintraub, ed. 325 pages. Philadelphia: WB Saunders; 2001. $45.00. ISBN 0443065586. Order phone 215-238-7800.Clinician's Guide to Holistic MedicineRA Anderson. 421 pages. New York: McGraw-Hill; 2001. $35.00. ISBN 0071347143. Order phone 800-262-4729.Health Care and Spirituality: Listening, Assessing, CaringRB Gilbert, ed. 313 pages. Amityville, NY: Baywood; 2001. $37.00. ISBN 0895032503. Order phone 800-638-7819.Integrated Cancer Care: Holistic, Complementary, and Creative ApproachesJ Barraclough, ed. 292 pages. New York: Oxford Univ Pr; 2001. $45.00. ISBN 0192630954. Order phone 800-451-7556.CardiologyAtrial Flutter: From Mechanism to TreatmentAL Waldo. 64 pages. Armonk, NY: Futura; 2001. ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 August 2001Volume 135, Issue 3Page: B1KeywordsComputed axial tomography ePublished: 7 August 2001 Issue Published: 7 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Triplets.
Authors: S. E. Hampton
Journal: JAMA (1895)

Milton, Ky., Nov. 23, 1895. <h3>To the Editor:</h3> —Mrs. Wm.H. Meiers, a German, primapara, 31 years of age, gave birth to two boys and one girl on the 17th inst. One, a boy, is still living, the other two having survived but a few hours. A woman in this (Trimble) County once gave birth to four children at one time.
From the Institute of Medicine
Authors: J. S. Durch
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GRISLY PASTIME
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal