tbuckley/cabot-search huggingface dataset:
Effects of branched-chain amino acid infusion on protein metabolism in rats with acute hepatic failure
Authors: Y MIWA
Journal: Hepatology (1995)

Branched-chain amino acids (BCAA) are known to improve hepatic encephalopathy as well as protein malnutrition in cirrhosis. However, such effects in acute hepatic failure (AHF) remain to be elucidated. The current study was conducted to investigate whether BCAA improves protein metabolism in AHF. AHF was induced in male Donryu rats weighing approximately 230 g by giving 60 mg/kg lipopolysaccaride intravenously and 800 mg/kg D-galactosamine hydrochloride intraperitoneally. From 18 hours after injection, AHF rats and control rats were given one of the following five solutions intravenously for 6 hours: (1) saline, (2) 10% glucose, (3) standard 10% amino acid formula with total nitrogen content of 12.2 g/L and BCAA/aromatic amino acid molar ratio of 37.05, (4) BCAA–enriched solution with nitrogen content of 21.9 g/L and the ratio of 148.2, or (5) an active placebo against BCAA-enriched solution with nitrogen content of 21.9 g/L and the ratio of 37.05. In parallel, each group was given a continuous infusion of 14C-leucine. After the plasma radioactivity of 14C-leucine and the expired 14CO2 level reached a plateau, protein turnover was analyzed according to the kinetic model proposed previously by Waterlow. When compared with the control, rates of total protein turnover (total flux), oxidation, and breakdown all increased significantly in AHF. Infusion of standard 10% amino acid formula, BCAA-enriched solution or the placebo in AHF increased total flux and oxidation significantly as compared with the effect of saline or 10% glucose. Although saline, 10% glucose, standard 10% amino acid formula, and the placebo had no effect on synthesis rate, it was increased significantly with BCAA-enriched solution. Breakdown was not suppressed with any solution. These results suggest that rats with AHF are in a catabolic state and that any of the three amino acid solutions can be oxidized to provide energy in AHF. In addition, infusion of BCAA-enriched solution may have a specific protein-sparing effect by increasing the protein synthesis rate even with liver damage. Hence, it is conceivable that infusion of BCAA improves protein metabolism in AHF. (HEPATOLOGY 1995; 22:291–296.)
Collaborators Omitted
Journal: JAMA (2014)

Richard J. McManus, FRCGP; Jonathan Mant, MD; M. Sayeed Haque, PhD; Emma P. Bray, PhD; Stirling Bryan, PhD; Sheila M. Greenfield, PhD; Miren I. Jones, PhD; Sue Jowett, PhD; Paul Little, MD; Cristina Penaloza, MA; Claire Schwartz, PhD; Helen Shackleford, RGN; Claire Shovelton, PhD; Jinu Varghese, RGN; Bryan Williams, MD; F.D. Richard Hobbs, FMedSci
Paying medical bills in the United States. Why health insurance isn't enough
Authors: R. J. Blendon
Journal: JAMA (1994)

IN THE COURSE of our nation's debate about health system reform, the discussion has frequently centered on the 38.9 million Americans who have no health insurance,<sup>1</sup>and the insecurity of millions more about their ability to maintain existing coverage in a time when health insurance and health care services costs are increasing rapidly. Indeed, a national survey of Americans conducted in the week following President Clinton's address about health care reform to Congress and the nation, 48% said the cost was their greatest concern about their health insurance, and 21% said they feared losing coverage or benefits.<sup>2</sup>In the same survey, one in five Americans (21%) indicated that their greatest concerns about health insurance coverage were related to the inadequacy of benefits they have, including gaps in coverage and lack of catastrophic or stop-loss provisions.<sup>2</sup> These kind of data are somewhat frustrating for those concerned about the health care reform debate because they provide measures of who is theoretically at risk for financial catastrophe—people without insurance, without adequate insurance, or concerned about the costs of medical care and health insurance—without providing concrete information about who has actually experienced difficulty paying medical bills. We have read the tragic stories of such individuals in newspapers and heard them presented to the Clintons in several health care forums, but we have yet to see detailed data about how many people in the United States are struggling to pay bills, and who they are. In this article, we use data from a recent national household survey of Americans to look directly, rather than at proxy measures, at who reports actual problems paying medical bills. We examine the insurance status of people in this group and, in addition, ask what other financial stresses they face and how they cope with the realities of illness and disability in their households.
寻常型天疱疮抗体
Authors: M. Ivars, A. España, P. Alzuguren, B. Pelacho, J.J. Lasarte, M.J. López‐Zabalza
Journal: British Journal of Dermatology (2020)

寻常型天疱疮是一种水疱性皮肤病,可能很严重。抗体是免疫系统在抗击疾病或感染时使用的一种蛋白质,但它们有时可以逆转健康细胞。寻常型天疱疮患者会产生各种蛋白的抗体,这些蛋白将某些皮肤细胞(表皮细胞)粘在一起,其中包括桥粒芯蛋白 1、桥粒芯蛋白 3 和桥粒芯胶蛋白,以及其他尚未识别的蛋白。 这些抗体引起的损伤导致表皮细胞分离,显微镜下可见(称为皮肤棘层松解),最终导致水泡形成。抗体可直接作用于这些蛋白,或通过激活其他炎性物质(包括去整合素和金属蛋白酶 10 (ADAM10))间接发挥作用。 位于西班牙北部的 Pamplona 的作者旨在了解寻常型天疱疮患者中不同抗体诱导的起泡是否涉及 ADAM10 激活。他们发现,桥粒芯胶蛋白的抗体触发了皮肤的早期分裂,与 ADAM10 无关。 然而,桥粒芯蛋白 1 和 3 抗体诱导的皮肤细胞分裂的时间和严重程度取决于抗体水平以及 ADAM10 的激活。在这类情况下,抑制 ADAM10 可防止皮肤棘层松解。 作者们提出,开发 ADAM10 抑制剂可用于治疗拥有桥粒芯蛋白 1 和 3 抗体的寻常型天疱疮患者亚组。 本摘要涉及研究:在皮肤粘膜寻常型天疱疮皮肤棘层松解中 ADAM10 的相关程度取决于每位患者的自身抗体谱。
More on the Doctor's Anguish
Authors: Thomas G. Hooyman
Journal: Annals of Internal Medicine (1993)

Letters1 August 1993More on the Doctor's AnguishThomas G. Hooyman, MDThomas G. Hooyman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-3-199308010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:None of the commentators [1] on the anguish of physicians Edwards and Tolle [2] criticized how they behaved as ethicists in the care of Mr. Larson, the manner in which they were invited to participate in his care. I write to mention a possible grave error made in the care of this patient, whose desire to forego life-sustaining treatment should not have been honored. The U.S. Supreme Court's decision regarding Nancy Cruzan legally established that a competent adult has the right to refuse all life-sustaining treatment, including artificial nutrition and hydration. An ethical argument, however, can be ...References1. Reflections on the doctor's anguish (Letters). Ann Intern Med. 1993; 118:78-80. Google Scholar2. Edwards MJ, Tolle SW. Disconnecting a ventilator at the request of a patient who knows he will then die: the doctor's anguish. Ann Intern Med. 1992; 117:254-7. Google Scholar3. Fry-Revere S. The Accountability of Bioethics Committees and Consultants. Frederick, Maryland: University Publishing; 1992:16. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1993Volume 119, Issue 3Page: 252-253KeywordsClinical decision support systemsDecision makingNutritionPatientsVentilatory support Issue Published: 1 August 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Critique &amp;amp; Cavil...
Authors: George X. Trimble
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis
Authors: J Medina
Journal: Hepatology (1997)

Chloride-bicarbonate anion exchanger 2 (AE2) is expressed in a variety of tissues, including the liver and salivary glands, where it may participate in the generation of hydroionic fluxes into secretions. We have previously reported decreased hepatic levels of AE2 messenger RNA in patients with primary biliary cirrhosis (PBC), a cholestatic condition frequently associated with pluriglandular exocrine failure. Here we investigated the expression of AE2 protein in the liver of PBC patients. Using a monoclonal antibody against an AE2 peptide, immunohistochemistry was performed on liver biopsy specimens from subjects with normal liver (n = 7), patients with PBC (n = 13), and patients with cirrhosis or cholestasis other than PBC (n = 17 and 11, respectively). Immunostaining was graded from 0 to 7, according to its intensity and distribution. AE2 immunoreactivity was observed in normal livers, as previously reported, and in many pathological liver biopsy specimens, being mainly restricted to canaliculi and the luminal membrane of terminal and interlobular bile ducts. Canalicular and ductular scores were significantly reduced in the PBC group compared with each control group (normal liver and cirrhosis or cholestasis other than PBC), whereas no differences in immunoreactivity scores were observed among control groups. When four patients with primary sclerosing cholangitis (PSC) were analyzed, they also differed from those with PBC. These results suggest that PBC is characterized by diminished expression of AE2 in the liver. Reduced levels of this transporter protein might be involved in the pathogenesis of cholestasis in PBC.
N-terminal pro-brain natriuretic peptide in relation to inflammation, myocardial necrosis, and the effect of an invasive strategy in unstable coronary artery disease
Authors: Tomas Jernberg, Bertil Lindahl, Agneta Siegbahn, Bertil Andren, Gunnar Frostfeldt, Bo Lagerqvist, Mats Stridsberg, Per Venge, Lars Wallentin
Journal: Journal of the American College of Cardiology (2003)
Thickness of Media of Pulmonary Trunk and Ascending Aorta in High Altitude Natives
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I/Ib Trial of the Efficacy and Safety of Combination Therapy with Lenalidomide/Bortezomib/Dexamethasone (RVD) and Panobinostat in Transplant-Eligible Patients with Newly Diagnosed Multiple Myeloma
Authors: Jatin J. Shah, Lei Feng, Elisabet E. Manasanch, Donna M. Weber, Sheeba K. Thomas, Francesco Turturro, Raymond Alexanian, Nina Shah, Uday R. Popat, Yago Nieto, Qaiser Bashir, Muzaffar H. Qazilbash, Richard E Champlin, Robert Z. Orlowski
Journal: Blood (2014)
Rehab
Authors: Carol Snyder Halberstadt
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Facial Injuries
Authors: Bradford Cannon
Journal: JAMA (1970)

One of today's most persevering chroniclers of the causes, prevention, and treatment of facial injuries is Richard C. Schultz. In the preface to his book he writes "It is not intended that this work be exhaustive or encyclopaedic but rather that it deal with the classification, discussion, and basic management of facial injuries commonly encountered in our society." He has done just that in a very orderly sequence, basing his conclusions on a series of 1,042 unselected patients from his own experience. More than 50% of the injuries resulted from automobile accidents; home accidents and athletic injuries account for 28% of the remainder. The mechanism of the injuries is portrayed with frightening line drawings, the nature of the injuries confirmed with photographs. After introductory chapters on anatomy and general care, with emphasis on emergency measures and the priorities of life-endangering injuries, there is a systematic descriptive outline of the diagnostic
Cognitive behaviour therapy is promising in childhood depressive disorder
Journal: BMJ (1998)

Cognitive behaviour therapy is promising in childhood depressive disorderOver the past 15 years there has been increasing recognition that children suffer depressive conditions.A systematic review concluded that tricyclics were of unproved benefit.On p 1559 Harrington et al present a systematic review of six trials of a common psychological treatment-cognitive behaviour therapy.The results suggest that it may be useful in mild or moderately severe cases of juvenile depression.Studies that compare cognitive behaviour therapy with antidepressant medication are now required.
Intracardiac Thrombi and Systemic Thromboembolism: Detection, Incidence, and Treatment
Authors: J. Chesebro
Journal: Annual Review of Medicine (1985)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Anson Jones (1798-1858), last president of the Republic of Texas
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heart Disease
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomised controlled trial of high versus low long chain triglyceride whole protein feed in active Crohn's disease
Authors: K Leiper
Journal: Gut (2001)

<h3>BACKGROUND</h3> Polymeric feeds have shown variable efficacy in active Crohn9s disease (CD) with remission rates from 36% to 82%. Meta-analyses of elemental, peptide, and whole protein feeds have shown a strong negative correlation between remission rate in CD and the long chain triglyceride (LCT) content of the feed. We performed a randomised controlled double blind trial in patients with active CD comparing two single whole protein feeds with LCT supplying 5% or 30% of the total energy. <h3>METHODS</h3> Fifty four patients with active CD (Crohn9s disease activity index (CDAI) &gt;200, serum C reactive protein (CRP) 10 mg/l) were randomised to a high or low LCT feed for three weeks. The total amount of energy supplied by fat was identical in the two feeds. Remission was defined as a CDAI ⩽150 and response as a fall in CDAI of ⩾70 or a CRP &lt;10 mg/l. <h3>RESULTS</h3> Overall remission rate by intention to treat was 26% for the low LCT feed and 33% for the high LCT feed (p=0.38). Response was achieved in 33% with the low LCT and in 52% with the high LCT feed (p=0.27). CRP &lt;10 mg/l was achieved in 30% in the low LCT and 33% in the high LCT group (p=0.99). Thirty nine per cent (21/54) of patients withdrew before three weeks because of inability to tolerate the diet. Excluding patients unable to tolerate the diet, remission rates were 46% for low LCT and 45% for high LCT (p=0.99). <h3>DISCUSSION</h3> This trial has shown no difference in the effect of low and high LCT whole protein feeds in active CD. The previously reported correlation between LCT content of diet and response in active CD is unlikely to be due to LCT itself and may be due to some other component of high LCT feeds.
Navy Surgeon.
Authors: William B. Bean
Journal: JAMA (1963)

Autobiography, even if it can tell only part of the truth, has a fascination, for it reveals a person's judgment of what he thinks his own life and experience may contain of general interest and importance. Every man is important to himself. Pugh's experiences in World War I and his later decision to enter the Naval Medical Corps are described with feeling. The latter part of his life, one of steady progression upward in Navy medical affairs, led to his appointment as Surgeon General of the Navy in the 1950's when the Korean affair gave new urgency to the routines of Naval medical matters. This is a warm story, liberally sprinkled with interesting tales, flashes of wit, and relatively little name dropping, that dangerous occupational hazard of biographers whom fate brought into contact with important people of their time. The book is unevenly written and would have been greatly improved
Another side of the coin
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Landmark article (JAMA 1912). Clinical features of sudden obstruction of the coronary arteries. By James B. Herrick
Authors: J. B. Herrick
Journal: JAMA (1983)

Obstruction of a coronary artery or of any of its large branches has long been regarded as a serious accident. Several events contributed toward the prevalence of the view that this condition was almost always suddenly fatal. Parry's writings on angina pectoris and its relation to coronary disease, Jenner's observations on the same condition centering about John Hunter's case, Thorvaldsen's tragic death in the theater in Copenhagen with the finding of a plugged coronary, sharply attracted attention to the relation between the coronary and sudden death. In Germany Cohnheim supported the views of Hyrtl and Henle as to lack of considerable anastomosis, and as late as 1881 lent the influence of his name to the doctrine that the coronary arteries were end-arteries; his Leipsic necropsy experience, as well as experiments on dogs, forced him to conclude that the sudden occlusion of one of these vessels or of one of the