tbuckley/cabot-search huggingface dataset:
Cancer Biology
Authors: Michael B. Shimkin
Journal: JAMA (1982)

The carefully nurtured hypertrophy of our concerns about cancer has led to, among other things, the proliferation of books about cancer at a rate exceeding the capacity of intellectual metabolism. Many such books are repetitive potboilers. Some are good. One in the latter category is the contribution of Raymond W. Ruddon, MD, PhD, of Michigan and a scientist of the National Cancer Institute at its Frederick station. Ruddon provides a status report in a rapidly moving field. The material is well presented and current, but also includes historically important contributions. The book is valuable for graduate, advanced students who are interested in oncology and are versed in molecular biology. For most clinicians, nurses, and more general readers, the book requires too much background. The first two chapters are introductory, outlining the pathology and distribution of cancer in man. Comparative pathology and epizootiology, from which much has been learned about cancer,
Basis for a National Reclamation Plan by Special Committee to Study Health and Environmental Effects of Increased Coal Production
Authors: H Dettmann, Anthony Dvorak, Douglas Grahn, Jerome Harper, James Lafevers, R Miller, Richard Olsen, Stephen O'connor, Jeffrey Schubert, Ralph Carter, Ray Hinchman, Donald Johnson, Andrew Sobek, Stanley Zellmer
Journal: Environmental Health Perspectives (1979)

The goal of the President's National Energy Plan to produce 1.25 billion tons of coal by 1985 may be achieved, but new legislation constraints and start-up delays may result in a production loss of 200-300 million tons.Well directed research to define the environmental consequence ofincreased coal production is underway, but it tends to be fragmented and ill coordinated.A national reclamation plan based on an achievable NEP must be developed that schedules, prioritizes, and
“Focus on…” session: high-dose chemotherapy
Authors: S Montoto, J Matthews, D Anderson, A Lister, J Gribben, D Villa, K Savage, M Crump, C Toze, M Rubinger, C Lee, M Alzahrani, R Foley, A Xenocostas, M Sabloff, D Stewart, N Chua, F Couture, J Larouche, J Kuruvilla
Journal: Annals of Oncology (2011)
Microangiopathic Hemolytic Anemia and the Development of the Malignant Phase of Hypertension
Authors: HARALAMBOS GAVRAS, WILLIAM C. B. BROWN, JEHOIADA J. BROWN, ANTHONY F. LEVER, ADAM L. LINTON, ROBERT F. MACADAM, GEORGE P. MCNICOL, J. IAN S. ROBERTSON, CHARLES WARDROP
Journal: Circulation Research (1971)
HOBBIES
Authors: Bruno Gebhard
Journal: JAMA (1953)

<h3>To the Editor:</h3> —I like that engaging new feature "The Leisure Corner," which I came across for the first time inThe Journalof July 4. Because the column so aroused my interest in spare time pursuits, I shall look forward to reading future pieces. The benefits of philately as a hobby were demonstrated July 11 to 27 at the Cleveland Health Museum during the Third National Medical Stamp Exhibit, sponsored by the museum and the Garfield-Perry Stamp Club of Cleveland. This exhibit featured stamps that are connected with medicine through their designs or reason for issue, together with pertinent background information. The extent of the background material depended on how much research each exhibitor could, or would, lavish on his hobby. The entries of Mrs. R. B. Leggett, Houston, Texas, were accorded honorable mention. Prior to the exhibition, her physician wrote that Mrs. Leggett has been bedridden for years
Table of Contents
Authors: Tien Nguyen, Judith Hong, Neil Prose, San Antonio, San Francisco, Michael Stierstorfer, Christopher Sha, Marvin Sasson, North Wales, Barbara Bo¨ckle, Gunda Stanarevic, Norbert Sepp, J Am, Acad Dermatol, Mohsin Mir, C Chan, Farhan Khan, Bhuvaneswari Krishnan, Ida Orengo, Theodore Rosen, ; Houston, Shawn Shetty, A Ahmed, ; Boston, Marcus Conant, Giovanni Ponti, Caterina Longo, Dongsi Lu, ; Chesterfield, Federica Ricceri, Leonardo Pescitelli, Lara Tripo, Francesca Prignano
Journal: Journal of the American Academy of Dermatology (2013)
Availability of Varicella Vaccine for Children With Acute Lymphocytic Leukemia
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Digitalis in heart failure. Farewell to the foxglove?
Authors: M. T. Sodums
Journal: JAMA (1981)

AFTER more than 200 years of clinical use, the role of digitalis therapy in the management of acute and chronic congestive heart failure and its effectiveness compared with vasodilator therapy is being questioned. This controversy results from the difficulty in demonstrating the salutary effect of digitalis on overall cardiac performance, although the positive inotropic effect of digitalis on left ventricular function, both in the normal and depressed ventricle, has been well established.<sup>1,2</sup>Accordingly, we will review the evidence for the beneficial effects of digitalis in acute (eg, myocardial infarction) and chronic heart failure and the relation between digitalis therapy and vasodilator therapy in these conditions. Net cardiac pump performance results from the complex interaction of several opposing factors<sup>3</sup>(Figure). Cardiac output is determined by the heart rate, left ventricular filling volume or preload, left ventricular afterload or resistance to left ventricular ejection (approximated by systolic blood pressure), and
Correction to: m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis
Authors: Dan Jin, Jiwei Guo, Yan Wu, Jing Du, Lijuan Yang, Xiaohong Wang, Weihua Di, Baoguang Hu, Jiajia An, Lingqun Kong, Lei Pan, Guoming Su
Journal: Journal of Hematology & Oncology (2020)

An amendment to this paper has been published and can be accessed via the original article.
DIMORPHIC
Authors: Ronald H. Cooper
Journal: Annals of Internal Medicine (1992)

Ad Libitum1 April 1992DIMORPHICRonald H. Cooper, MDRonald H. Cooper, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-7-602_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFUNGIINDUSTRIOUS MICROBESRECYCLING THE ENVIRONMENTPROVIDING MAN WITH PLEASUREDISEASE... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tacoma, WA 98467 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHomogeneous Hydroformylation of Ethylene Catalyzed by Rh 4 (CO) 12 . The Application of BTEM to Identify a New Class of Rhodium Carbonyl Spectra: RCORh(CO) 3 (π-C 2 H 4 ) 1 April 1992Volume 116, Issue 7Page: 602-602 ePublished: 1 December 2008 Issue Published: 1 April 1992 PDF downloadLoading ...
Holiday Gynecomastia
Authors: Armin E. Heufelder, Matthew C. Leinung, Robert C. Northcutt
Journal: Annals of Internal Medicine (1992)

Letters15 May 1992Holiday GynecomastiaArmin E. Heufelder, MD, Matthew C. Leinung, MD, Robert C. Northcutt, MDArmin E. Heufelder, MDSearch for more papers by this author, Matthew C. Leinung, MDSearch for more papers by this author, Robert C. Northcutt, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-10-877_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:The differential diagnosis of acute swelling and tenderness of the male breast involves considering occupational hazards, medications, recreational drugs, and estrogen-containing topical agents as well as erotic and nonerotic mechanical stimulations. We were recently consulted by a 28-year-old health care worker with resolving bilateral gynecomastia, which had begun a month earlier after a 1-week vacation in the Virgin Islands. The initial physical examination was remarkable only for enlargement of both breasts with marked tenderness and swelling of both nipples and areolar areas. No breast secretions were noted. Bilateral mammography did not reveal any masses. Full resolution of...References1. Cobbvan Thiel CD. Mechanisms of ethanol-induced adrenal stimulation. Alcoholism. 1982;6:202-6. CrossrefGoogle Scholar2. NorthWalter RR. The effects of alcohol on the endocrine system. Med Clin North Am. 1984;68:133-46. CrossrefMedlineGoogle Scholar3. FaraDel-Corvo GG. Epidemic of breast enlargement in an Italian school. Lancet. 1979;2:295-7. CrossrefMedlineGoogle Scholar4. CoulstonWills FJ. Epidemiological studies relating to the use of hormonal agents in animal production. Enviro Qual Saf Suppl. 1976;5:238-52. Google Scholar5. Rosenblumvan ThielCampbell EDI. Separation and identification of phyto-estrogenic compounds isolated from bourbon. Alcohol Alcohol. 1987;1:551-5. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Armin E. Heufelder, MD; Matthew C. Leinung, MD; Robert C. Northcutt, MDAffiliations: Mayo Clinic and Foundation Rochester, MN 55905. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced GynecomastiaEvaluation of breast enlargement in young males and factors associated with gynecomastia and pseudogynecomastiaUnilateral Pseudogynecomastia: A Novel Work-Related DiseaseS. Hanneken, MD, R. Kruse, MD, P. Dall, MD, T. Ruzicka, MD, and N. J. Neumann, MD 15 May 1992Volume 116, Issue 10Page: 877-877KeywordsDrugsEstrogensHealth care providersInflammationMammography ePublished: 1 December 2008 Issue Published: 15 May 1992 PDF downloadLoading ...
Medicine in the USA: historical vignettes. II. Medical education: the early phases
Authors: L. S. King
Journal: JAMA (1982)

When the early colonists came from England, the medical men who accompanied them belonged to the lower part of the professional spectrum. They were, for the most part, apothecaries and surgeons, more skilled in practice than in theory. After many decades, however, as life in the colonies became more attractive, better-trained men, often with university education, joined the immigrant ranks. In addition to those who had had some formal medical training in the mother country, the colonial practitioners included lay persons who had acquired a smattering of knowledge and whose ministrations were sought by those with no other recourse. In isolated communities there might be no other than self-appointed healers, whose good faith and intentions we do not doubt, whatever reservations we may have about their competence. From this latter group, there was a transition to the inevitable quacks and frauds. Ministers of the gospel often provided medical assistance, especially
Correction
Journal: Circulation (2004)

In the article, "Cost Effectiveness of Defibrillation by Targeted Responders in Public Settings," by Nichol et al, which appeared in the August 12, 2003, issue of the journal (Circulation.2003;108:697-703), an error appeared.This economic evaluation of defibrillation in various public settings was based on incorrect interpretation of the number of defibrillators required at each site. 1 The following Table corrects this error.The revised incremental costs are less than previously estimated.However, the authors reconfirm that those making decisions to implement lay responder defibrillation should consider the likelihood of cardiac arrest and the number of defibrillators required at the site.
Endoscopic Treatment of Benign Anastomotic Colorectal Stenosis with Electrocautery
Authors: G Brandimarte, A Tursi, G Gasbarrini
Journal: Endoscopy (2000)

Benign anastomotic colorectal stenosis can occur after surgery and can require surgical or endoscopic dilation. This study aimed to investigate the use of electrocautery in this area.We enrolled 39 consecutive patients (25 men, 14 women; mean age 61, range 48-77) suffering from anastomotic colorectal stenosis, demonstrated by colonoscopy (19 patients) or by barium enema (20 patients). We performed endoscopic dilation of the strictures with electrocautery once only in each patient.In all patients we obtained dilation of the strictures without any immediate or delayed procedure-related complications. No recurrence of the stenosis was demonstrated during a follow-up of a mean of 25 months (range 8-43 months).This study shows that endoscopic electrocautery is a safe and effective treatment of anastomotic colorectal stenosis.
EYE STRAIN.
Authors: LEWIS S. DIXON
Journal: JAMA (1905)

The subject of eye strain, including the need for wearing glasses, has for some years been rapidly forcing itself into prominence and has assumed an importance far beyond any expectation. It is in no sense a fashion or fad, though there are many such in medicine. The eyes are, and have been in the past, the unsuspected cause of a great variety of nervous disturbances that were never understood and never satisfactorily explained. Modern methods of study, which have lately accomplished such wonders in all branches of science, when applied to the eye have brought order and truth out of what had been a tangle of theory, supposition and uncertainty. The eye has always been studied simply as a part of the body, under physiology; it needed to be studied as an optical instrument, under optics, a branch of science in which our knowledge is mathematically accurate. Strange to say
HISTORY OF HISTORIES
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anatomy
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment decisions about cholesterol: what about smoking?
Authors: J. H. Lutschg
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DATE OF THE NEW ORLEANS MEETING.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Martin Luthers Umwelt, Charakter und Psychose sowie die Bedeutung dieser Faktoren für seine Entwicklung und Lehre: Eine historischpsychiatrische Studie
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asymptomatic cavitary sarcoidosis
Authors: H. W. Bistrong
Journal: JAMA (1970)

Sarcoidosis is an unusual cause for solitary cavitation of the lung. Its occurrence had been associated with advanced pulmonary and parenchymal involvement. Case reports of cavitary formation clearly due to sarcoidosis are rare. There has been no previous report of cavitary sarcoidosis occurring in an asymptomatic patient.
Announcement
Authors: Norman Sartorius, G. Reister, W. Tress, H. Schepank, R. Manz, B. Sollors-Mossler, T. Reitter, W. Tress, Tom Sensky, D.M. Rodrigues, J.F. Pontes, Marco Rigatelli, Massimo Marcon, Antonia Morritti, Isao Fukunishi, Isao Fukunishi, A.L. Rodrigues, Tom Sensky, M.C. Ventura, R. González, A. Alarcón, A. Morro, E. Llabres, Roger Zumbrunnen, Maria S. Kopp, Maximino Lozano, Carmen Carcedo, Rosario Artigao, David Huertas, Ana O'Neill of Tyrone, Carmelo Pelegrin, J.M. Maroto, Llnis Jordá, Sandra Conti, Gianni Savron, Giovanna Bartolucci, Silvana Grandi, Carlo Magelli, Franco Semprini, Francesco M. Saviotti, Giancarlo Trombini, Giovanni A. Fava, Bruno Magnani, Ayuso Mateos, Bayon Perez, Santo-Domingo Carrasco, D. Olivares, Tom Sensky, Richard Petty, Paul M. Copeland, G. Savron, S. Grandi, L. Michelacci, F.M. Saviotti, G. Bartolucci, S. Conti, G. Trombini, L. Bovicelli, C. Orlandi, G.A. Fava, Ayuso Mateos, Bayon Perez, Santo-Domingo Carrasco, J de Salas Jimenez de Azcarate, D. Olivares, Franco Baldoni, Bruno Baldaro, Mauro Ercolani, Emilio Emili, Giancarlo Trombini, G. Burloux, P. Forestier, J. Dalery, J. Guyotat, Francisco J. Vaz-Leal, Calvo Sagardoy, Fernandez Ashton, Ayuso Mateos, Bayon Perez, Santo-Domingo Carrasco, M. Takei, S. Nozoe, H. Tanaka, Y. Soejima, Y. Manabe, I. Takayama, T. Yamanaka, Morten Birket-Smith, Helle Charlotte Knudsen, Jørn Nissen, Niels Blegvad, Ole Køhler, Dorte Rasmussen, Søren Worm-Petersen, Kathleen Franco, Nancy Campbell, Marijo Tamburrino, Steve Jurs, Judith Pentz, Cynthia Evans, Hans Kordy, Michael von Rad, Wolfgang Senf, Per Fink, Jørgen Jensen
Journal: Psychotherapy and Psychosomatics (1989)
Testicular disease in acute lymphoblastic leukaemia in childhood. Report on behalf of the Medical Research Council's Working Party on leukaemia in childhood.
Journal: BMJ (1978)

In three trials conducted by the Medical Research Council on acute lymphoblastic leukaemia in childhood the incidence of testicular infiltration in relation to presenting features and treatment was analysed. Initial severe thrombocytopenia was associated with an increased incidence. Testicular infiltration was occasionally found during treatment in patients with high blood leucocyte counts at diagnosis but the main incidence in patients with all types of disease occurred within one year of stopping treatment. The incidence may be increased when "second-line" drugs, especially cyclophosphamide, have been used. A reappraisal of the value of additional drugs in maintenance treatment of patients with good prognosis is needed.