tbuckley/cabot-search huggingface dataset:
Dr. A. C. Nicol
Journal: British Journal of Sports Medicine (1971)

medicine first in Sydney, then London, and qualified in 1923.He obtained the Fellowship of the Royal College of Surgeons of Edinburgh in 1928, but spent most of his professional life in London.After the war he was one of that group of specialists in various branches of medicine who moved into the new specialist field of physical medicine.His earlier background in Australia, with his later interests in rehabilitation, made him a most valuable adviser to the Amateur Swimming Association, and he was a prime mover in the physiological assessment of the athlete, and the assessment of his physical fitness by objective tests administered by the coaches.He was a founder member of the B.A.S.M.Dr. Kendall 's many visits to Loughborough whenever young swimmers were undergoing courses of intensive training, and whenever coaches were being trained, gave a stimulus to the scientific approach to training and fitness, measurement that spread to many sports outside swimming.I myself feel a deep debt of gratitude to Dr. Kendall for introducing me to this field, and for his encouragement over many years.Besides his physiological interests, Dr. Kendall also put his extensive clinical experience at the disposal of the swimmers, and was one of those who pioneered a high level of medical care for the athletic team.He was a good teacher and very fair examiner for those taking coaching wards, and he was one of that devoted band of officials who was always willing, to hold a stopwatch or to do any other task required during competitions.He encouraged his son Patrick to become a swimmer of repute and received all our sympathy on Patrick 's tragic death three years ago.The deaths of son then father, so close together, leave a large gap in sports medicine, and in Physical medicine in this country.H. E. R.
Web Site Discontinued
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology of Fine Particulate Air Pollution and Human Health: Biologic Mechanisms and Who's at Risk?
Authors: C. Arden Pope
Journal: Environmental Health Perspectives (2000)

This article briefly summarizes the epidemiology of the health effects of fine particulate air pollution, provides an early, somewhat speculative, discussion of the contribution of epidemiology to evaluating biologic mechanisms, and evaluates who's at risk or is susceptible to adverse health effects.Based on preliminary epidemiologic evidence, it is speculated that a systemic response to fine particle-induced pulmonary inflammation, including cytokine release and altered cardiac autonomic function, may be part of the pathophysiologic mechanisms or pathways linking particulate pollution with cardiopulmonary disease.The elderly, infants, and persons with chronic cardiopulmonary disease, influenza, or asthma are most susceptible to mortality and serious morbidity effects from short-term acutely elevated exposures.Others are susceptible to less serious health effects such as transient increases in respiratory symptoms, decreased lung function, or other physiologic changes.Chronic exposure studies suggest relatively broad susceptibility to cumulative effects of long-term repeated exposure to fine particulate pollution, resulting in substantive estimates of population average loss of life expectancy in highly polluted environments.Additional knowledge is needed about the specific pollutants or mix of pollutants responsible for the adverse health effects and the biologic mechanisms involved.
Prolonged delirium after metrizamide myelography
Authors: R. L. Elliott
Journal: JAMA (1984)

MYELOGRAPHY with metrizamide (Amipaque) is an increasingly popular technique useful in the evaluation of radiculopathy. The most common neurologic side effects are headache, nausea, vomiting, and dizziness.<sup>1-3</sup>More serious neuropsychiatric side effects reported include confusional states, hallucinations, sleep disturbances, agitation, and other signs of altered mental status.<sup>1-5</sup>These changes have been reported as brief, lasting less than 48 hours, and benign in outcome. We report a case, the first, to the best of our knowledge, in which the symptoms appearing after metrizamide myelography were severe and prolonged. A brief discussion of the etiology and treatment of these side effects follows the case presentation. <h3>Report of a Case</h3> A 56-year-old woman had a three-year history of low back and right leg pain precipitated by a minor injury. After an exacerbation of the pain that was not relieved by 14 days of bed rest, she was admitted to the hospital.
Cerebral Death
Authors: Richard L. Masland
Journal: JAMA (1978)

When may a person be declared dead? Traditionally it has been held that "if in the opinion of a physician,... there is absence of spontaneous respiration and cardiac function, death will have occurred." Modern methods of support of respiration and circulation have made these criteria obsolete and indicate that when the brain is dead, the person is dead, regardless of the presence of respiration or a systemic circulation. In addition, the current need for viable organs for transplantation makes it imperative to develop simple, reproducible, and valid criteria for the prompt determination of brain death. In 1971 the National Institute of Neurological Diseases and Stroke (NINDS, with Dr A. Earl Walker as coordinator) established a collaborative program involving nine institutions to "identify the criteria that may characterize persons in a state of cerebral death." Included in the study were 503 cases selected from 844 patients in whom cerebral unresponsiveness and
NCCN Task Force Report: Bone Health and Cancer Care
Authors: Richard L. Theriault, J. Sybil Biermann, Elizabeth Brown, Adam Brufsky, Laurence Demers, Ravinder K. Grewal, Theresa Guise, Rebecca Jackson, Kevin McEnery, Donald Podoloff, Peter Ravdin, Charles L. Shapiro, Matthew Smith, Catherine H. Van Poznak
Journal: Journal of the National Comprehensive Cancer Network (2006)

Higher incidences of osteoporosis and osteopenia are found in cancer patients, particularly in women receiving aromatase inhibitors or with chemotherapy-induced ovarian failure, or in men with prostate cancer and androgen deprivation therapy. Therefore, management of long-term bone health is emerging as an important aspect of comprehensive cancer care. Patients with cancer typically have a number of additional risk factors for osteoporosis that should prompt screening, regardless of patient age or sex. Maintaining bone health requires a broad knowledge base, including understanding underlying bone metabolism and how it is affected by both cancer itself and the drugs used to treat cancer, the effect of chemotherapy-induced menopause on bone health, bone markers and imaging techniques used to assess bone health, therapeutic strategies to maintain bone health, and treatment of bone metastases, including surgery for pathologic fractures. Multiple members of the healthcare team may need to be involved in education and care of the patient. This report summarizes discussion of these and other issues regarding bone health and cancer care from the NCCN Bone Health and Cancer Care Task Force meeting in early 2006. ( JNCCN 2006;4(Suppl 2):S1-S24)
DOCTORATES IN LAW FROM A MEDICAL COLLEGE.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE POLICY OF THE UNIVERSITY OF LONDON IN RELATION TO LONDON MEDICAL EDUCATION AND MEDICAL SCIENCE
Authors: W. Hunter
Journal: BMJ (1907)

SIN{CE the policies pursued in the three great University centres of London, Edinburgh, and Cambridge present -distinctive features, the policy of the University of London in relation to medical education was in my last article 'inferentially contrasted with that of the two great Universities of Edinburgh and of Cambridge, by whose prosperity that of London has undoubtedly been most effected.The comparison with Cambridge in particular was specially invited by the original basis of the " Univer- sity of London," namely, that it was: " A Board of examiners to perform all the functions of -the examiners in the Senate of Cambridge, this body to ,be termed the 'University of London "'(1835).It was further invited by the additional important statute passed in 1854:
HOUSE OF DELEGATES
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Geophagia
Authors: Michael C. Gelfand
Journal: JAMA (1975)

Geophagia has been associated with life-threatening hyperkalemia in five patients with chronic renal failure. All five patients were black and had been born in the southeastern United States. Four had had frequent hyperkalemia requiring at least one hospitalization, and two had had hyperkalemia with serum potassium concentration as high as 9.8 mEq/liter, resulting in cardiac arrest in one and paralysis, disorientation, and cardiac arrythmia in the other. Since riverbed clay contains as much as 100 mEq of potassium in 100 gm of clay, much of which is exchangeable at acid pH, the mechanism of geophagia-induced hyperkalemia appears to be the absorption of potassium released from clay after ingestion. After discontinuing geophagia, no new hyperkalemic episodes occurred in these patients. (<i>JAMA</i>234:738-740, 1975)
<i>Les Obsessions et la Psychasthenie II. Fragments des lecons cliniques du mardi sur les etats neurastheniques, les aboulies, les sentiments d' incompletude, les agitations et les angoisses diffuses, les algies, les phobies, les delires du contact, les tics, les manies mentales, les folies du doute, les idees obsedantes, les impulsions, leur pathogenie et leur traitement</i>. Par. Prof. F. Raymond Et Pierre Janet. (Paris, 1903, Felix Olcan)
Authors: W. R. D.
Journal: American Journal of Psychiatry (1903)
Is stent oversizing the best strategy to treat small vessels? Fausto Feres, Marco A. Costa, Rodolfo Staico, Alexandre Abizaid, Ibraim M. F. Pinto, Luiz A. P. Mattos, Galo Maldonado, Luiz F. L. Tanajura, Marinella Centemero, Aurea Chaves, Andrea S. Abizaid, Ana C. Seixas, Angela T. Paes, Amanda G. M. R. Sousa, J. Eduardo M. Sousa. Institute Dante Pazzanese of Cardiology, S�o Paulo, Brazil
Journal: Journal of the American College of Cardiology (2001)
Shall The Journal be Removed to Washington?
Authors: Thomas H. Manley
Journal: JAMA (1891)

<h3>To the Editor:</h3> Now that the question of changing the location ofThe Journalis under consideration, it is important that no time be lost in plainly laying before our readers and members the reasons why its removal should be demanded, and there is no place or no medium through which the matter can be better, fairer or more fully considered, than in that weekly, which is the property of us all; for it may as well be generally known that this transference of location cannot be consummated<i>except through specious, delusive argument, wily manipulating and shrewd diplomacy, with the aid of sharp parliamentary tactics;</i>in other words, by a genuine<i>coup détat</i>. Our membership is bound by no alliances, can afford to act independently, and must be prepared to meet and neutralize by a compact and concentrated majority. So far I have not seen a<i>single valid reason</i>why
PERITONEAL SUPPORTS—(LIGAMENTUM PERITONEI).
Authors: BYRON ROBINSON
Journal: JAMA (1895)

<h3>THE GREAT OMENTUM.</h3> Synonyms: mesogastrium posticum, posterior mesogaster epiploön, gastro-colic omentum, omentum majus, ligamentum gastro-colicum, apron or caul. The great omentum is a double fold of peritoneum which stretches from the mid-dorsal line to the greater curvature of the stomach and concave surface of the duodenum. The mesogaster posterior and the meso-duodenum are one and the same mesentery. It is twisted into the shape of the letter S, with one loop of the S larger than the other on its stomach aspect. The ligamentum hepato-duodenale has dragged the pylorus toward the right from the atrophy of the liver. The mesogaster (posterior) or the great omentum is very long and wide, and easy to inspect. But the mesoduodenum is so changed by the rotation of the great intestinal loop that it is not readily inspected. However, if one dissects up the transverse colon it will be seen that the whole mesoduodenum
Pulmonary and Percutaneous Absorption of 2-Propoxyethyl Acetate and 2-Ethoxyethyl Acetate in Beagle Dogs
Authors: Derek Guest, Marva L. Hamilton, Peter J. Deisinger, George D. DiVincenzo
Journal: Environmental Health Perspectives (1984)

A comparison was made of the absorption and elimination rates of 2-propoxyethyl acetate (PEA) and 2-ethoxyethyl acetate (EEA) following inhalation, dermal application or IV administration. Male beagle dogs were exposed to 50 ppm PEA or EEA for 5 hr, and breath samples were collected during the exposure and a 3-hr recovery period. Both compounds were rapidly absorbed through the lungs. After 10 min of exposure, the concentrations of the parent compounds in the expired breath were 5 to 10 ppm (80-90% absorption) and reached plateau values at about 3 hr of 13 ppm for PEA (74% absorption) and 16 ppm for EEA (68% absorption). Post-exposure breath samples declined exponentially to 0.5 ppm and 2 ppm after 3 hr for PEA and EEA, respectively. Expired concentrations of PEA were slightly, but significantly (p less than 0.025), lower than those of EEA at corresponding times during the exposure. After IV dosing with 1 mg/kg [ethyl-1,2-14C]PEA, the urine contained 61% and 88% of the dose in 4 and 24 hr, respectively. [14C]EEA was eliminated more slowly, with 20% and 61% of the dose appearing in the urine in 4 and 24 hr, respectively. Blood elimination half-lives were 1.6 hr for [14C]PEA and 7.9 hr for [14C]EEA. Only trace amounts of 14CO2 (less than 1%) or volatile materials (less than 0.1%) were detected in the expired air with either compound. For studies of percutaneous absorption, [14C]PEA or [14C]EEA was added to undiluted compound and applied in a glass cell to a shaved area on a dog's thorax for 30 or 60 min.(ABSTRACT TRUNCATED AT 250 WORDS)
Industrial carcinogenesis
Authors: C.F.H. VICKERS
Journal: British Journal of Dermatology (1981)

Journal Article Industrial carcinogenesis Get access C.F.H. VICKERS C.F.H. VICKERS Department of Dermatology, University of Liverpool, L69 3BX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s21, 1 September 1981, Pages 57–61, https://doi.org/10.1111/j.1365-2133.1981.tb01311.x Published: 01 September 1981
Abstract 988: Tissue Inhibitor Of Metalloproteinase-3 Regulates Myocardial Fibrosis By Regulating The TGFβ-TNF Interaction
Authors: Zamaneh Kassiri, Mehrdad Hariri, Shalini Anthwal, Gavin Y Oudit, Fayez Dawood, Peter P Liu, Rama Khokha
Journal: Circulation (2007)

Fibrosis is the outcome of excess deposition of extracellular matrix components and underlies diastolic and systolic heart failure. Metalloproteinases (MMPs and ADAMs) and their inhibitors (TIMPs) are critical regulators of ECM turnover and fibrosis. TIMP3 is a potent inhibitor of MMPs and ADAMs, whereby it regulates tissue proteolysis and cytokine bioavailability. TIMP3 levels are reduced in human heart disease, and we found that mice lacking Timp3 (KO) exhibit severe dilated cardiomyopathy (DCM), extensive interstitial fibrosis and early heart failure (HF) following pressure overload compared to wild type (WT) mice. We showed upregulated TNF signaling within 6 hrs of aortic banding (AB) which when blocked, significantly improved DCM and prevented HF. We then investigated the mechanism underlying the extensive fibrosis despite the increased MMP activity in the TIMP3KO mice. Comparative microarray analyses show a significant upregulation of the TGFβ1 signaling pathway within 6 hrs of AB in KO vs WT hearts. In vivo treatment of KO-AB mice with a TGFβ1-neutralizing antibody (1D11) completely abolishes fibrosis, markedly improves left ventricular dilation, systolic and diastolic heart function (LVEDD(mm): 4.3 ± 0.1 in WT, 5.4 ± 0.1 in KO, 4.7 ± 0.1 in KO+ 1D11; fractional shortening(%): 40.2 ± 1.7 in WT, 19.6 ± 2.2 in KO, 36.2 ± 0.7 in KO+ 1D11; E/Ac ratio: 2.5 ± 0.3 in WT, 1.8 ± 0.3 in KO, 2.4 ± 0.2 in KO + 1D11; n = 22, P &lt; 0.05). Interestingly, blocking TGFβ1 also prevented the early rise in TNF in KO hearts. Using primary neonatal culture systems, we found that cardiomyocyte-fibroblast interaction is essential for a fibrotic response to agonists (Ang II, PE). Further, KO co-cultures generate a 5-fold greater fibrosis (P &lt; 0.05) through activation of Smad2/3 pathway compared to WT. TGFβ also regulates TNF transcription more potently in KO cells since a 3-fold higher TNF induction occurred in response to recombinant TGFβ1 in KO vs WT co-cultures (P &lt; 0.05). In conclusion, TIMP3 is a critical regulator of TGFβ1 and TNF, and its deficiency induces parallel dysregulations in the signaling of these cytokines very early after pressure overload, leading to severe interstitial fibrosis and DCM, hence, TIMP3-based therapies can simultaneously impact fibrosis and DCM.
Acute renal failure following hexol-induced abortion
Authors: D. L. Gornel
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Follow-Up of Deaths Among U.S. Postal Service Workers Potentially Exposed to
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Care for the Hispanic poor: a growing segment of American society
Authors: E. Munoz
Journal: JAMA (1988)

AMERICA'S new minority group is coming of age: the Hispanic. Surges in Hispanic birth rates and legal and illegal immigration make this growing component of American society a population to be reckoned with. Hispanics totaled 21 million Americans in 1987 (7.9% of the US population).<sup>1</sup>The Hispanic population is expected to increase 40% by the year 2000 (to almost 30 million people). Birth rates for Hispanics are three to four times that of the non-Hispanic white population. Most of us in health care see a lot of this new "poor" American in our clinics and emergency departments, sick and Spanish speaking. Hispanics, with a median age of 23 years, are younger than the US population as a whole. Hispanics (on average) are poor. About 30% of all Hispanic families are living below the poverty level compared with 15% of the total US population. One of every five Hispanic adults,