tbuckley/cabot-search huggingface dataset:
Histopathological heterogeneity in fulminant hepatic failure*1
Authors: C HANAU
Journal: Hepatology (1995)

The clinicopathological features of 38 patients admitted consecutively for fulminant hepatic failure were studied. Histopathological material was reviewed in all patients. Both percutaneous and whole livers (either explanted or autopsy specimens) were available in 16 patients: whole livers only in 12 patients and biopsy specimens only in 10 patients. All patients were negative for antibodies to hepatitis C, whereas 24% had hepatitis B infection and 10% had adverse drug reactions. Livers from 75% of patients showed confluent hepatic necrosis. However, there was considerable variability in the extent of necrosis, and biopsy specimens from about 50% of the most severely affected livers showed only minimal bridging necrosis. In patients with massive hepatic necrosis, percutaneous liver biopsy specimens were frequently misleading because of regional inhomogeneities. Interestingly, five patients (13%) had established cirrhosis at the time of diagnosis. The best clinical predictors of survival were age and the maximal grade of encephalopathy. By contrast, neither the severity of confluent hepatic necrosis nor the etiology predicted the decision to transplant or the outcome. There were no differences in the histopathology corresponding to different etiologies. In summary, the approach to the patient with fulminant hepatic failure should be guided principally on clinical grounds, and further classification should be based on pathological and etiologic considerations. However, histological classification and prognosis based on percutaneous biopsy specimens alone may be misleading.
State-Specific Prevalence of Current Cigarette Smoking Among Adults and Secondhand Smoke Rules and Policies in Homes and Workplaces—United States, 2005
Journal: JAMA (2006)

Smoking causes premature death and disease in children and adults who do not smoke but are exposed to secondhand smoke (SHS). To assess the state-specific prevalence of current smoking among adults in the United States and the proportions of adults who report having smoke-free home rules and smoke-free policies in their workplace, CDC analyzed data from the 2005 Behavioral Risk Factor Surveillance System (BRFSS). This report summarizes the results of that analysis, which indicated a threefold difference (from lowest to highest) in self-reported cigarette smoking prevalence in 50 states, the District of Columbia (DC), Puerto Rico (PR), and the U.S. Virgin Islands (USVI) (range: 8.3%-28.7%). Wide variations also were observed in USVI and the 14 states that assessed prevalence of smoke-free home rules (from 63.6% [Kentucky] to 82.9% [Arizona]) and smoke-free workplace policies (from 54.8% [Nevada] to 85.8% [West Virginia]). Evidence-based, comprehensive tobacco prevention and control programs that focus on decreasing smoking initiation, increasing smoking cessation, and establishing smoke-free workplaces, homes, and other venues should be continued and expanded to reduce smoking prevalence, exposure of nonsmokers to SHS, and smoking-related morbidity and mortality.
ASSOCIATION NEWS.
Authors: L. Duncan Bulkley
Journal: JAMA (1897)

<h3>The Philadelphia Meeting.</h3> Philadelphia, May 24, 1897. <h3>To the Editor:</h3> —The arrangements are thoroughly completed for the reception and accommodation of those of the profession who expect to attend the semi-centennial meeting to be held in Philadelphia June 1. The Committee of Arrangements has every reason to believe that visitors will be satisfied with the meeting places which have been prepared for them and we are ready to entertain as many of the profession as may honor us by their presence. I append to this letter the latest information in regard to the Section dinners. It is earnestly hoped that all those who belong to Sections, or who intend to belong to Sections, will write to the gentlemen whose names are attached to each notice of a Section dinner, engaging a plate. It will also interest those of the profession who intend bringing their families with them, to learn that
THE ETIOLOGIC RELATION EXISTING BETWEEN CERTAIN NEUROSES AND DIET, AND ITS THERAPEUTIC APPLICATIONS.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICAL FAMILIES
Authors: James P. Sharon
Journal: JAMA (1941)

<h3>To the Editor:—</h3> I am enclosing a record of a medical family which I think rather interesting. I am staying at the home of the last name, Dr. Richard M. Titterington, who supplied me with these facts. Grandfather: Adam L. Titterington M.D. Born 1789 Great Uncle: Joseph Titterington M.D. 10-23-1813 Uncles: Richard Titterington M.D. 11-6-1819 Cousins: James Titterington M.D. James Titterington M.D. 2-19-1824 (1) Cousins: Lee Titterington, M.D. D.D.S. (2) Clyde Titterington, D.D.S. (3) James Titterington, D.D.S. John Q. Titterington M.D. 5-3-1826 Cousins: Jesse Titterington M.D. Robert Titterington M.D. Daniel Titterington 5-15-1828 Cousins: James Titterington M.D. Jesse M. Titterington M.D. Father: Alfred Titterington M.D. 7-7-1834 Richard M. Titterington D.D.S. (Informant) I am staying at the home of the last name, Dr. Richard M. Titterington, who supplied me with these facts.
Accidental Narcosis
Authors: Leonard K. Lackore
Journal: JAMA (1970)

In an attempt to avoid pulmonary oxygen toxicity from developing in patients whose ventilation is being continuously assisted with positive-pressure cycled ventilators, the ventilators may be driven by compressed air from a centralized compressor. The following case illustrates a potentially disastrous complication which can occur with the misuse of this system. <h3>Report of a Case</h3> A 54-year-old quadriplegic white man had his ventilation assisted, or controlled, as needed by means of a rocking bed, a Thompson pneumobelt, and a pressure cycled ventilator which was powered by compressed air from a wall outlet. While the patient's ventilation was being controlled with the pressure cycled ventilator, his wife reported that he was less responsive than usual and kept wanting to go to sleep. About two hours later, a nurse found him to be completely unresponsive, and she was unable to obtain a blood pressure reading or to palpate his pulse clearly. She
<i>Recherches cliniques et thérapeutique sur l'Épilepsie, l'Hystérie et l'Idiotie. Campte-rendu du service des enfants idiots épileptiques et arriérés de Bicêtre pendant l'année,1900, par Bourneville, etc.</i>(Paris, Progrès Médical, 1901.)
Journal: American Journal of Psychiatry (1902)
Subspecialty Work Force Issues
Authors: Lewis G. Sandy
Journal: Annals of Internal Medicine (1995)

Letters15 May 1995Subspecialty Work Force IssuesLewis G. Sandy and Steven A. SchroederLewis G. SandyFor the Association of Subspecialty Professors, Philadelphia, PA 19104. The Robert Wood Johnson Foundation, Princeton, NJ 08543-2316.Search for more papers by this author and Steven A. SchroederFor the Association of Subspecialty Professors, Philadelphia, PA 19104. The Robert Wood Johnson Foundation, Princeton, NJ 08543-2316.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-10-199505150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We applaud the Association of Subspecialty Professors' continued commitment to addressing subspecialty work force issues. The Association continues to voice skepticism over existing work force projections and prefers need-based modeling. However, decades of research have been devoted to the study of physician-induced demand [1, 2], highlighting the instability of population “need.” Moreover, the number of physicians required for any population's “need” is sensitive to population and organizational factors, such as service regionalization.Although we agree with the Association that the United States is headed towards an excess of physicians in aggregate, existing projections estimate that the bulk of ...References1. Menken M. Consequences of an oversupply of medical specialists: the case of neurology. N Engl J Med. 1983; 308:1224-6. Google Scholar2. Reinhardt UE. Health manpower forecasting: the case of physician supply. In: Ginsberg E, ed. Health Services Research: Key to Health Policy. 1991; 278-80. Google Scholar3. Weiner JP. Forecasting the effects of health reform on U.S. physician workforce requirement: evidence from HMO staffing patterns. JAMA. 1994; 272:220-30. Google Scholar4. Cohen JJ. From the president: time to stanch the flow of residents. Acad Med. 1994; 69:464-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Lewis G. Sandy; Steven A. SchroederAffiliations: For the Association of Subspecialty Professors, Philadelphia, PA 19104. The Robert Wood Johnson Foundation, Princeton, NJ 08543-2316. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStrategic business planning for internal medicine 15 May 1995Volume 122, Issue 10Page: 804KeywordsHealth careSub-specialty care ePublished: 15 August 2000 Issue Published: 15 May 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Diagnostic and therapeutic technology assessment. Continuous arteriovenous hemofiltration
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Urban Doctors Program
Authors: J. T. Daugirdas
Journal: JAMA (1971)

Our goal in setting up the I Urban Doctors Program was to train physicians from and for the poverty communities of the Chicago area. We wanted to produce physicians who might practice in these communities not because they were "incentivated" to do so, either monetarily or otherwise, but because they saw this form of practice in their own neighborhoods as personally and professionally rewarding. We believed that there were two variables we could affect at the medical school level to improve the chances of producing this type of community-oriented physician. For the sake of discussion, let us call these "input" and "process." First, we examined the backgrounds of medical students at Northwestern University and at urban medical schools in general. We found that few students at these schools came from poverty communities in the area. We realized that a commitment by a medical school to train people from these communities
Cosmetic Breast Augmentation and Suicide
Authors: David Sarwer
Journal: American Journal of Psychiatry (2007)

Objective: This article discusses the unexpected relationship between cosmetic breast implants and suicide that has been found in six epidemiological investigations completed in the last several years. Method: The epidemiological studies are reviewed. Results: Across the six studies, the suicide rate of women who received cosmetic breast implants is approximately twice the expected rate based on estimates of the general population. Although the first study of this issue suggested that the rate of suicide among women with breast implants was greater than that of women who underwent other forms of cosmetic surgery, the largest and most recent investigation in this area found no difference in the rate of suicide between these two groups of women. Conclusions: The higher-than-expected suicide rate among women with cosmetic breast implants warrants further research. In the absence of additional information on the relationship, women interested in breast augmentation who present with a history of psychopathology or those who are suspected by the plastic surgeon of having some form of psychopathology should undergo a mental health consultation before surgery.
A randomized trial comparing two different retention periods of intravesical pirarubicin instillation for intermediate risk non-muscule-invasive bladder cancer after transurethral resection.
Authors: Yoshiaki Kawano, Yoshihiro Wada, Wataru Takahashi, Yutaka Sugiyama, Ken-ichiro Tanoue, Masatoshi Eto
Journal: Journal of Clinical Oncology (2014)

TPS4591 Background: Anthracyclines are recommended reagents for one immediate intravesical instillation after transurethral resection (TUR) and additional adjuvant instillation in intermediate risk non-muscule invasive bladder cancer (NMIBC) to reduce the risk of recurrence. Pirarubicin (THP), an anthracycline analogue, is widely used reagent for intravesical instillation chemotherapy. Several studies have showed that THP can rapidly penetrate tumor tissue after intravesical instillation. Therefore long instillation time (e.g. 120 min) may not be required for its prophylactic effect against recurrence since it may reduce the risk of adverse events such as cystitis and hematuria without compromising its efficacy. However, there is no high level evidence regarding optimized intravesical THP instillation time in terms of both toxicity and efficacy. Methods: This randomized, prospective, open-label trial intends to enroll 160 pts with primary non-muscle invasive bladder cancer (NMIBC) with intermediate risk based on EORTC criteria. All pts receive initial THP instillation within 24 hr after TUR-Bt followed by weekly repetitive THP instillation for a total of 9 treatments. Pts are randomized into two groups with different intravesical THP retention times, (a) 30 min versus (b) 120 min. Eligibility criteria include pts with pathological diagnosis of urotherial carcinoma, with complete tumor resection by TUR-Bt, and with ECOG-PS 0-2. Exclusion criteria include pts who had previously treated with therapeutic BCG intravesical instillation or prophylactic maintenance intravesical instillation of anti-cancer drug, with coexisting cancer, and with history or coexistence of upper urinary tract urothelial cancer. Follow-up period is 3 years. Primary endpoint is change from baseline in quality of life (assessed by SF36, OABSS and I-PSS), which will be evaluated every 3 months until 2 years after TUR, then half-yearly for another year. Secondary endpoint is recurrence-free survival rates at 1, 2 and 3 years, and safety. Currently 82 pts have enrolled. Clinical trial information: UMIN000006861.
Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed by Single-Cell-Initiated Transsynaptic Tracing
Authors: Santiago B. Rompani, Fiona E. Müllner, Adrian Wanner, Chi Zhang, Chiara N. Roth, Keisuke Yonehara, Botond Roska
Journal: Neuron (2017)

(Neuron 93, 767–776; February 22, 2017) In the originally published version of this article, the source of the B7GG cells, BHK-EnvA cells, and TVA-expressing 293T cells was attributed to the laboratory of Karl-Klaus Conzelmann. It should have been attributed to the laboratory of Edward Callaway. This error has now been corrected in the article online. The authors apologize for the error and any inconvenience that may have resulted. Different Modes of Visual Integration in the Lateral Geniculate Nucleus Revealed by Single-Cell-Initiated Transsynaptic TracingRompani et al.NeuronFebruary 22, 2017In BriefRompani et al. employ single-cell-initiated transsynaptic tracing to decipher patterns of input integration in the thalamus. They show that individual cells in the lateral geniculate nucleus integrate retinal inputs in three distinct modes, each exhibiting different degrees of specialization. Full-Text PDF Open Access
Innocent
Authors: H. Joan Waitkevicz
Journal: Annals of Internal Medicine (2004)

On Being a Doctor6 July 2004InnocentH. Joan Waitkevicz, MDH. Joan Waitkevicz, MDFrom South Florida.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-1-200407060-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I came to South Florida from an urban medical practice in the North. Three years later, I am still surprised by many things. Mango trees, royal palms, egrets, ibises, and pelicans are commonplace. A fly-by of squawking green parrots is a treat.One big difference is how my neighbors experience poverty. Here, people who don't have a car are poor in a way that could not be imagined in New York City. You have to wait until a neighbor can drive you for your food, toiletries, medical visits, anything at all. Or, in 80- to 90-degree weather, you must walk ... Author, Article, and Disclosure InformationAffiliations: From South Florida.Note: City withheld at the request of the health center's director.Corresponding Author: e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 July 2004Volume 141, Issue 1Page: 75KeywordsChildrenFemale contraceptionHIV infectionsHealth careInfantsMortalityObstetrics and gynecologyPregnancySexually transmitted diseasesWalking ePublished: 6 July 2004 Issue Published: 6 July 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Reply
Authors: Zong-Gen Peng, Xue-Fu You, Jian-Dong Jiang
Journal: Hepatology (2011)

We thank Alisi et al.1 for their interested in our research on the anti–hepatitis C virus (HCV) activity of human apolipoprotein B messenger RNA–editing enzyme catalytic polypeptide (APOBEC3G, also known as hA3G),2 and believe that their consideration is valuable for our investigation. Basically, adenosine deaminases that act on RNA (ADARs) and cytidine deaminases are two generic classes of deaminases. Homology between hA3G and ADAR at neither messenger RNA nor protein level is recognized. ADARs act at double-stranded (ds) RNA. They catalyze the A-to-I editing reaction on dsRNA, causing nucleotide substitution and dsRNA destabilization. The effect of ADARs on viruses is complicated with variability, such as ADAR concentration, viral strains, among others.3 Transgenic mice overexpressing wild-type or deaminase-deficient ADAR2 protein exhibited metabolic alterations characterized with hyperphagia and adult onset obesity;4 knockout of the ADAR gene in mice caused high lethality.5-7 Thus, ADARs might not be an ideal drug target for virus. hA3G belongs to the family of cytidine deaminases. It acts at either RNA or DNA, and mediates hydrolytic deamination at the C4 position of the cytidine (C) or deoxycytidine (dC) base, converting C to uracil (U) (or dC to dU). hA3G inhibits replication of RNA as well as DNA viruses.8 The hA3G-mediated viral restriction is not simply via editing, and other mechanisms such as inhibition on tRNA3Lys annealing to viral RNA, or on reverse transcription, often play key roles.8 The anti-HCV activity of hA3G appeared not to be mediated through its RNA editing function.2 A proviral effect of hA3G has not been documented. Furthermore, APOBEC3 is not essential for development, survival, or fertility in mouse experiments;9 overexpression of hA3G did not alter cell growth,2 suggesting its potential as a drug target. Zong-Gen Peng Ph.D.*, Xue-Fu You M.D.*, Jian-Dong Jiang M.D.*, * Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, China.
Correction
Journal: BMJ (1952)

ANY QUESTIONS ? of cysticercosis may be difficult.It is important to establish the history of possible exposure.Excision and examination of the subcutaneous nodules which may be present may lead to the identification of the larval stages of the worm.It may be necessary to examine the whole body, including the head, by radiographs in order to identify the shadows of calcified cysts.Boy or Girl ?Q.-A well-developed healthy child was noticed at birth to have no scrotum.The child is now 3 months old.The penis and prepuce are well developed, slightly larger than usual for the age, but the skin posterior to the penis 'is smooth, and shows a slight dimpling in the middle line with a faint outline on the skin suggesting a vulva.No -testes can be felt.How should the sex be established ?What treatment is advised ?A.-If there was a maldevelopment of the penis and urethra, such as hypospadias, one would be more con--cerned with the possibility of pseudohermaphroditism.As, ,however, these appear to be normal it seems more likely -that the condition is one of congenital defective or delayed development of the scrotum.In such a case I have seen the scrotum develop adequately after daily local inunction *of 1 g.testosterone ointment (containing 25 mg.testosterone propionate to the gramme) for several weeks.If a scrotal *sac is thus developed, it is not unlikely that the testicles will descend into it, but if not injections of gonadotrophins might -be considered at a later stage.Speaking more generally, if the sex is in doubt, the only sure way of establishing it is to do a biopsy of the gonads.Where they are not externally palpable an abdominal laparotomy will be necessary.