tbuckley/cabot-search huggingface dataset:
73TiP SOLTI1710 PROMETEO II: Palbociclib in combination with letrozole in hormone receptor-positive (HR+)/HER2-negative residual disease after standard neoadjuvant chemotherapy (NAC)
Authors: E. Ciruelos, F.J. Salvador Bofill, A. Perello Martorell, E. Alba Conejo, X. González-Farré, P. Palacios-Ozores, M. Merino, P. Villagrasa, E. Vila Navarro, T. Pascual, A. Prat, S. Pernas Simon
Journal: Annals of Oncology (2021)
Clinical Use of Lactic Dehydrogenase
Authors: Russell J. Erickson, Daniel R. Morales
Journal: New England Journal of Medicine (1961)

THE determination of lactic dehydrogenase (LDH) activity has received attention in several medical centers both as an investigative tool and as a clinical laboratory procedure because of the promise that it has shown in the diagnosis and prognosis of certain diseases. However, conflicting results, diverse methods of assay and different methods used to express LDH have produced a picture that is often difficult to interpret. In undertaking this review of the literature, we have kept in mind both the investigator in this field and the practicing physician who wishes to familiarize himself with the current status of LDH in medicine, . . .
Testing for BRCA1 in hereditary breast cancer
Authors: G. H. Vance
Journal: JAMA (1995)

<h3>To the Editor.</h3> —I recently received a lovely and expensive marketing pamphlet from OncorMed of Gaithersburg, Md, announcing the availability of testing for the<i>BRCA1</i>gene by linkage analysis. This was, to my knowledge, the first commercial advertisement for<i>BRCA1</i>testing. Before this time, linkage studies have been performed on a research basis at only a few centers in this country. In order to be considered for linkage, families needed to be large with multiple affected living members. I telephoned the sales representative listed in the brochure to inquire about testing. He responded that the scientific board of OncorMed had decided not to offer testing at the present time. I think that OncorMed has falsely advertised its role in testing for familial cancer. However, with the publicity surrounding testing for<i>BRCA1</i>, advertisements like this only increase the demand for testing to assess individual breast cancer risk. Raising this demand while
AVIATION MEDICINE
Journal: Annals of Internal Medicine (1944)

Article1 March 1944AVIATION MEDICINEB. GROESBECK JR.B. GROESBECK JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-3-367 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty years ago, had I then had the honor of addressing the American College of Physicians on the subject of Aviation Medicine, I probably would have spent my allotted time profitably describing just what aviation medicine means. Today, however, such an explanation is unnecessary. The number of flight surgeons, the number of physicians who practice aviation medicine, has grown to such a degree as almost to parallel the growth of aviation itself, and the medical profession is now aware that aviation medicine exists. Particularly in the services, the specialty of aviation medicine, if you wish to term it that, is... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: M. C. U. S. NAVY Naval Air Training Center Pensacola, Florida*Presented April 16, 1943 New Orleans, Louisiana Regional Meeting, American College of Physicians.The opinions or assertions contained herein are the private ones of the writer and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErnährungskrankheiten 1 March 1944Volume 20, Issue 3Page: 367-370KeywordsSurgeons Issue Published: 1 March 1944 PDF downloadLoading ...
Notes on Dr. Camp's Lectures in Neurology
Journal: JAMA (1935)

This is a small volume produced by the new method of lithoprinting, which makes the text look as though it had been well typewritten. It contains summaries of lectures given in neurology at the University of Michigan and would naturally have the fault of being second-hand material, although one may be sure that Dr. Camp himself must have checked the book before permitting its publication. Except for students at that particular university, it is difficult to see any single group for which this book would be more useful than other short textbooks. The descriptions of diseases are too short, as a rule, to be a substitute for even the smaller standard neurologic textbooks. Some of the more obscure diseases are dealt with in such a way that not even the most elementary signs and symptoms are enumerated. In all probability they should either have been omitted or a little bit
Subxiphoid pericardiotomy
Authors: R. H. Breyer
Journal: JAMA (1982)

<h3>In Reply.—</h3> The experience of Breyer and associates supports our impression that subxiphoid pericardiotomy is a procedure of choice for the treatment of acute cardiac tamponade. It is of particular note that these authors report one patient with a small right ventricular laceration from an attempted, but unsuccessful, pericardiocentesis. No complications from subxiphoid pericardiotomy occurred. The shorter drainage time reported by Breyer et al underscores the need to individualize removal of the catheter based on the quantity of daily drainage. We routinely remove the catheter when less than 30 mL of fluid has been drained during a 24-hour period. It is apparent from the data provided by Breyer et al that our population, which contained more uremic patients, experienced a much greater quantity of drainage fluid of from 300 to 3,400 mL (average, 1,133 ±192 mL). The longer drainage periods were not unexpectedly associated with the cases of highest fluid
Commentaire de travail de B.-S. Sheu et al., pp. 942
Journal: Endoscopy (2007)

See also: The presence of dental disease can be a risk factor for recurrent Helicobacter pylori infection after eradication therapy: A 3-year follow-upEndoscopy 2007; 39(11): 942-947DOI: 10.1055/s-2007-966787
Diagnosis of Duchenne and Becker muscular dystrophies by polymerase chain reaction. A multicenter study
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Steroid Arthropathy.
Authors: Charley J. Smyth
Journal: Annals of Internal Medicine (1965)

s1 May 1965Steroid Arthropathy.Charley J. Smyth, M.D., F.A.C.P., John D. Leidholt, M.D., Edward E. Velayos, M.D.Charley J. Smyth, M.D., F.A.C.P.Search for more papers by this author, John D. Leidholt, M.D.Search for more papers by this author, Edward E. Velayos, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1097_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe frequency of so-called "avascular necrosis of bone" after systemic and intra-articular adrenocorticosteroid therapy in connective tissue disorders is increasing. Eleven patients who developed joint destruction and had a radiologic diagnosis of aseptic bone necrosis will be reported. Ten of these cases had received oral steroids, and one with systemic lupus erythematosus (SLE) had never received steroid therapy. Six patients had rheumatoid arthritis (RA); three had SLE and two had kidney homotransplants for severe renal disease and received high doses of steroids as immunosuppressive agents.Joint tissues removed at the time of surgery or autopsy in six cases were examined... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1097-1097KeywordsAutopsyBoneConnective tissueImmunosuppressivesLupus erythematosusNecrosisRenal diseasesRheumatoid arthritisSteroid therapySurgery Issue Published: 1 May 1965 PDF downloadLoading ...
Section Discussions
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Postencephalitic Respiratory Disorders. Review of Syndromy, Case Reports, Physiopathology, Psychopathology and Therapy.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Standardizing measurement of tobacco use in cancer clinical trials.
Authors: Stephanie R Land, Graham Walter Warren, Carol Moinpour, Jamie S. Ostroff, Jennifer Crafts, Jasmine Folz, James L. Gulley, Eva Szabo, Veronica Chollette, Thomas H. Brandon, Sonia Duffy, Dorothy K. Hatsukami, Carolyn M. Dresler, Ellen R. Gritz, Robert Schnoll, Linda Sarna, Nancy Rigotti, Jan C. Buckner, Sandra A. Mitchell, Benjamin Toll
Journal: Journal of Clinical Oncology (2015)

9550 Background: ASCO and AACR recommend assessment of tobacco use (TU) for all cancer patients, but there is little consensus regarding approaches for reliable, valid, and clinically meaningful TU measurement. Our aim was to develop clinically efficient evidence-based assessments that can be applied across research settings, and to provide expert recommendations for the timing of assessment. Methods: In 2013-2014, an expert Task Force developed candidate TU measurement items via consensus dialog and systematic evaluation of existing tools. From 9/2014-1/2015, in-depth, semi-structured cognitive interviews were conducted with three rounds of cancer patients to evaluate patient comprehension, memory retrieval, and judgment of draft versions of the instrument. Interviews were abstracted into structured reports tabulating cognitive difficulties. A subcommittee convened to recommend modifications. Results: Two tiers of TU measurement items were developed: a core set for all cancer studies, and a longer menu of curated items for use when comprehensive assessment is feasible. Domains include TU history, status and intensity relative to cancer diagnosis and treatment; other tobacco products; cessation approaches; and second hand smoke. We interviewed 22 participants (mean age 64; 68% male; 50% college educated; with cancers of the prostate (n = 8), bladder (3), colon & rectum (1), lung (7), pancreas (1), testis (1), thymus (1)). Numerous instrument improvements addressed patients’ understanding of wording, response options, and recall periods. The final version performed well. Task Force recommendations also include a protocol for assessments at baseline and follow-up. Conclusions: These results provide preliminary support for content validity of the TU assessment instrument. Standardized TU assessment implemented in research across a range of disease sites and treatment modalities will permit data pooling and comparisons between populations. Recommendations facilitate TU assessment in clinical trials and will enable researchers to identify novel clinical interactions, better understand the effects of TU on cancer treatment efficacy and toxicity, address cessation, and ultimately improve clinical outcomes.
Unusual cause of acute abdomen. Sickle cell trait and nonhypoxic splenic infarction
Authors: D. T. King
Journal: JAMA (1977)

Splenic infarction under hypoxic conditions is a well-known complication of sickle cell trait (Hgb AS). However, this case illustrates that it may occur without any clinical conditions or circumstances associated with decreased Pao<sub>2</sub>. In addition, sickle cell trait should be included in the differential diagnoses of splenic infarction even if the patient is not of African ancestry. (<i>JAMA</i>238:2173-2174, 1977)
Error in Results
Authors: Elizabeth Loder, Rebecca Burch
Journal: JAMA Neurology (2018)

tific evidence suggests that the new antibody treatments are not more effective than many existing therapies. 2 In the absence of clearly superior efficacy, prudence suggests that less expensive treatments of comparable benefit and with a wellunderstood safety profile should be used first.The monoclonal antibodies appeared to be well-tolerated in trials, but accumulating experience since their approval suggests that adverse events are more common in clinical use.In particular, severe constipation, nausea, and fatigue have emerged as treatment-limiting adverse effects for some patients. 3,4 Charles dismisses worries about potential cardiovascular adverse events.He cites a study of 88 patients at high cardiovascular risk who received a single dose of 140-mg intravenous erenumab or placebo before exercise stress testing with no major association with exercise time.In our view, a singledose study provides no information about the long-term cardiovascular safety of chronic CGRP inhibition.The study also was too small to reliably assess less common adverse events that might be caused by these treatments.
MEDICINE AND THE OLYMPICS
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 149: Targeting Protein Tyrosine Phosphatase PTP-PEST for Therapeutic Interventions in Acute Myocardial Infarction
Authors: Chiu-Fen Yang, Yi-Yun Chen, Ching-Feng Cheng, Tzu-Ching Meng
Journal: Circulation Research (2017)

Introduction: To date reperfusion remains the only established clinical management to salvage ischemic myocardium. However, reperfusion also results in additional damage. New interventions that prevent myocardial injury caused by ischemia/reperfusion (I/R) are the unmet clinical need. A hallmark of I/R-induced cardiac signaling perturbation is dysregulation of protein tyrosine phosphorylation (pTyr), which is dynamically controlled by protein tyrosine phosphatases (PTPs) and protein tyrosine kinases (PTKs). Recent works showed that forced activation of myocardial PTKs reduces I/R injury to the heart, suggesting a detrimental effect of protein tyrosine dephosphorylation by PTPs on the survival of myocardium. However, the role of PTPs in this disease context has never been explored. Hypothesis: PTPs may act to promote I/R-induced injury to the heart. Methods: Mice received the surgery for myocardial ischemia (1 h) followed by reperfusion (4 h). We measured the myocardial PTP activity, the pTyr level of cardiac proteins, and the degree of heart injury. To suppress endogenous PTP activity, mice were treated with phenyl vinyl sulfone (PVS), a pan-PTP inhibitor. Results: We found that the overall myocardial PTP activity was significantly elevated after ischemia and I/R, in line with a decrease of pTyr in cardiac proteins. Interestingly, PTP-PEST, which is abundantly expressed in myocardium, underwent protease-processed activation in the heart exposed to I/R. Consistently, the pTyr of paxillin and p130CAS, both which are the substrates of PTP-PEST, was significantly diminished. Treatment of the mice with PVS, an inhibitor that inactivates PTP-PEST, protected the heart from I/R injury. Conclusion: Our finding suggests that PTP-PEST may be a new target against myocardial I/R injury. The current focus is to validate the role of PTP-PEST in cardiac I/R damage and to test the therapeutic effect of drugable PTP-PEST inhibitors. New pharmacological interventions may be designed for improving the outcome of myocardial infarction.
THE "HUNGER STRIKE" OF CHILDREN
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-Dose Oral Vitamin D Supplementation and Risk of Falls in Older Women
Authors: Renato Bertini Malgarini
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Are chlamydial infections the most prevalent venereal disease?
Authors: J. Schachter
Journal: JAMA (1975)

We studied two population groups (more than 1,600 patients) to determine the prevalence and clinical associations of genital tract infections with chlamydiae and herpesviruses. Base-line isolation rates for asymptomatic women having routine pelvic examinations were much lower than rates for symptomatic women. In both groups, chlamydiae were more prevalent than herpesviruses. Chlamydial infection was associated much more commonly with cervicitis (36.6%) than with vaginitis only (4.1%). Among 282 symptomatic men, the cultures of 19.9% yielded chlamydiae, and 4.3%, herpesviruses. Chlamydiae were recovered from 35.5% (27 of 76) of specimens from men with nongonococcal urethritis, and from an even larger proportion, 57% (24 of 42), of the specimens from men with frank discharge. (<i>JAMA</i>231:1252-1255, 1975)