tbuckley/cabot-search huggingface dataset:
Abstract 4091: Evaluating the efficacy of a STING agonist in a murine model of prostate cancer
Authors: Jonathan Gurkan, Jae Eun Choi, Jean Tien, Marcin Cieślik, Luigi Franchi, Arul M. Chinnaiyan
Journal: Cancer Research (2019)

Abstract Despite the promise of checkpoint inhibitor therapy, prostate cancer has remained resistant to this treatment. Innate immune agonists, however, have been shown to have anti-tumor effects in various cancer types, such as melanoma and colon cancer, and have been nominated to be used in combination with approved anti-PD1/PD-L1 drugs. For instance, STING agonist + anti-PD-1 combination therapy has been demonstrated in a syngeneic mouse model of melanoma. Other innate immune agonists, such as TLR7/8 and TLR9 have also been shown to have potential anti-tumor effects. We hypothesized that innate immune agonists may be effective in the MycCaP syngeneic mouse model of prostate cancer. To compare the efficacy of three innate agonists targeting the STING (3’3’ cGAMP), TLR7/8 (CL097), and TLR9 (ODN2395) pathways, FVB mice were first injected bilaterally with MycCaP subcutaneous tumors. Upon establishment of tumors, mice were administered 3 doses of a single-sided intratumoral injection of each drug. The injected tumors had responses of 50% (6/12), 23% (3/13), and 8% (1/13) for the STING, TLR7/8 and, TLR8 agonists, respectively. Contralateral tumors showed no significant regression. Published data have reported inherent resistance of MycCaP tumors to anti-PD-1 treatment in vivo. Given our results, we hypothesize that the addition of a STING agonist could enhance efficacy of anti-PD-1 therapy in this model. Mice with MycCaP tumors were administered anti-PD1 alone (n=10) or in combination with bilateral injections of the STING agonist (n=14). Combined therapy resulted in significant reduction in tumor size (71%) compared to anti-PD1 alone (9%). Additionally, there was a significant increase in the Ifnb1 (p=.04), Ifng (p=.008), Tnf-α (p=.006), IRF3 (p=.003) and II6 (p&amp;lt;.0001) gene expression in the combination group showing enhancement of the STING pathway genes. Combined, these findings suggest that targeting the STING pathway may have a modest local anti-tumor effect when compared to other innate immune pathways in prostate cancer. The efficacy of anti-PD-1 therapy was significantly enhanced when combined with a STING agonist, possibly through enhancement STING pathway genes. Our data suggest that combination therapy with a STING agonist and anti-PD1 therapy may have potential anti-tumor efficacy in prostate cancer. Future studies will examine these effects on both local and abscopal tumors. Citation Format: Jonathan Gurkan, Jae Eun Choi, Jean Tien, Marcin Cieślik, Luigi Franchi, Arul M. Chinnaiyan. Evaluating the efficacy of a STING agonist in a murine model of prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4091.
Endoscopic negative pressure therapy with open-pore film drainage and open-pore polyurethane sponge drainage for iatrogenic perforation of the esophagus
Authors: Dörte Wichmann, Dietmar Stüker, Ulrike Schempf, Christoph R. Werner, Volker Steger, Alfred Königsrainer, Ulrich Schweizer, Rami Archid
Journal: Endoscopy (2020)

Correction to:Endoscopic negative pressure therapy with open-pore film drainage and open-pore polyurethane sponge drainage for iatrogenic perforation of the esophagusEndoscopy 2020; 52(05): 377-382DOI: 10.1055/a-1139-0772
Medical Schools in Canada
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SYPHILIS IN THE ETIOLOGY OF NERVOUS DISEASES.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MPTH-59. ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMAS: A CLINICOPATHOLOGIC AND MOLECULAR PROFILE
Authors: Devorah Segal, Cheddhi Thomas, Christopher Bowman, Kasthuri Kannan, Shiyang Wang, Adriana Heguy, Benjamin Liechty, David T. W. Jones, Volker Hovestadt, Stefan M. Pfister, Matthias Karajannis, Matija Snuderl
Journal: Neuro-Oncology (2016)
Abstract 2620: C1q Exacerbates Mitochondrial Dysfunction Without Activation Of The Terminal Complement In Neonatal Mice With Hypoxic-ischemic Brain Injury.
Authors: Vadim S Ten, Casper Caspersen, Sivasankar Baalasubramanian, Paul Morgan, Marina Botto, Anatoly Starkov, Richard Polin
Journal: Circulation (2007)

Deletion of C1q protects developing brain against hypoxia-ischemia (HI) (Ten V et al; 2005). Hypothesis. C1q mediates HI-brain injury by: Activation of terminal complement or/and Exacerbation of mitochondrial dysfunction. Hypothesis (1) P7 WT (C57Bl/6j) pre-treated with vehicle or sCD59; progenies of C1q+/-, Factor B/C2-/-/-/- inter-mating were subjected to HI: ligation of right carotid artery + hypoxic exposure. At 24 hr of reperfusion the extent of damage, cerebral deposition of C1q, C3, iC3b and C9 were assessed. Hypothesis (2) In C1q-/-and WT mice cerebral ATP-content, mitochondrial O2-consumption rate, H2O2-production and membrane potential (î»m) were studied immediately after HI. At 12 hr electron microscopy for co-staining of C1q and gC1qR/p33 in neurons was performed. WT and C1q-/- cortical and granule neurons in culture were subjected to glutamate or energy failure stress (EFS), glucose deprivation and exposure to 5 mM Na azide. At 24 hr after stress cellular viability, C1q protein and C9 mRNA expression were examined. Results. C1q-/- mice were significantly protected against HI compared to +/+ counterparts. This was associated with robust attenuation of deposition of C3, iC3b and C9 in brain. However, no protection was detected in FB/C2-/ -/ -/ - and sCD59-pretreated mice, although C9-deposition in the injured brain was significantly decreased compared to controls. C1q-/ - mice exhibited a stunning preservation of ATP in the ischemic brain immediately after HI. This was associated with higher O2-consumption rate in state 3 and significantly (two-folds) less production of H2O2 by C1q-/ - mitochondria compared to WT-counterparts without difference in the î»m. In WT-mice HI resulted in intraneuronal, and intramitochondrial accumulation of C1q and gC1qR/p33 only in the ischemic hemisphere. C1q-/ - vs WT cultured neurons were significantly protected against excitotoxic and EFS in the absence of C9-mRNA in cellular lysate. Conclusion. C1q mediates HI-injury. Terminal complement activation has no role in C1q-mediated neuronal damage. The presence of C1q is associated with significantly increased mitochondrial ROS-production in HI-brain. This may represent a novel mechanism for HI-neurodegeneration.
Congenital Adrenal Hyperplasia and Adult Sexual Behavior
Authors: Constance J. Johnson
Journal: JAMA (1997)

<h3>To the Editor.</h3> —In the Commentary on the safety of long-term prenatal glucocorticoid treatment, Drs Seckl and Miller<sup>1</sup>state, "Furthermore, it has been suggested that fetal androgens can 'masculinize' the human brain, as adult females with CAH [congenital adrenal hyperplasia] have a higher incidence of lesbianism, less interest in sexual activity, and a negative body image; prenatal dexamethasone may diminish this potential action of fetal androgens." This implies that being a lesbian is a masculinized state and also is a negative outcome. Clearly there is much to be learned about human behavior, and studies that further our knowledge should be applauded. However, homosexuality is not a pathologic condition and should not be framed as such in the medical literature. Furthermore, lesbians are not masculinized women. The perpetuation of these negative stereotypes is a disservice to all gay and lesbian colleagues and patients.
River blindness
Authors: Chibuzo Odigwe
Journal: BMJ (2003)

Chibuzo Odigwe explains the history and current treatment strategies for a disease that has been a large scale problem in Africa since recorded history began From the beginnings of recorded history, onchocerciasis has been a problem in Africa, as folklore and orally preserved tradition indicate. But it has also been described on the Arabian Peninsula and the Americas. An estimated 18-40 million people are currently affected worldwide, with about 270 000 people having lost their sight as a result. About 99% of the people living with onchocerciasis are in Africa with about half of this population in Nigeria alone. Onchocerciasis is caused by Onchocerca volvulus , a nematode of the family Filariiadae , whose vector is the blackfly, Simulium damnosum . Because the black fly prefers to lay its eggs in fast flowing rivers, onchocerciasis is endemic in these areas--giving rise to its more familiar name of river blindness. ### Historical notes
A SAFETY DEVICE FOR ROENTGEN-RAY TUBES
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Determination of Nicotine, pH, and Moisture Content of Six US Commercial Moist Snuff Products--Florida, January-February 1999
Journal: JAMA (1999)

The use of smokeless tobacco (moist snuff and chewing tobacco) can cause oral cancer and precancerous oral lesions (leukoplakia) and is a risk factor for cardiovascular diseases and nicotine addiction. Despite these adverse effects, smokeless tobacco is used commonly in the United States by young people, especially male high school students. Officials in Florida requested CDC assistance in analyzing six moist snuff products to measure three factors that affect their nicotine dose: pH, nicotine content, and moisture content. This report summarizes the results of the analysis, which indicate that the pH, amount of nicotine, and moisture vary widely among brands.
Vermont State Medical Association.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reducing the rate of cesarean deliveries. An obtainable but elusive goal
Authors: R. W. Hale
Journal: JAMA (1994)

The article by King and Lahiri,<sup>1</sup>reported elsewhere in this issue ofThe Journal, attempts to quantify factors influencing the incidence of vaginal birth after a previous cesarean delivery (VBAC). From a retrospective analysis of data on 13944 births occurring in 1989 to New York State women with a history of cesarean delivery, the authors report small increases in the odds of VBAC for those women with higher levels of education, who delivered in hospitals with intensive and intermediate neonatal care facilities, and who were members of health maintenance organizations. They did not find any effect of professional liability factors on VBAC rates. King and Lahiri are to be commended for undertaking this difficult and arduous task. This report is especially timely following recent reports on the rates of unnecessary cesarean delivery. A scientifically based analysis of the reasons for and against repeat cesarean delivery is clearly needed. The
The Tongue
Authors: Paula Tatarunis
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progressive nodular histiocytosis accompanied by systemic disorders
Authors: A. Gonzalez Ruiz, A.I. Bernal Ruiz, H. Aragoneses Fraile, I. Peral Martinez, M. Garcia Munoz
Journal: British Journal of Dermatology (2000)

Journal Article Progressive nodular histiocytosis accompanied by systemic disorders: Progressive nodular histiocytosis accompanied by systemic disorders Get access A. Gonzalez Ruíz, A. Gonzalez Ruíz Dermatology and Search for other works by this author on: Oxford Academic Google Scholar A.I. Bernal Ruíz, A.I. Bernal Ruíz Dermatology and Search for other works by this author on: Oxford Academic Google Scholar H. Aragoneses Fraile, H. Aragoneses Fraile Dermatology and Search for other works by this author on: Oxford Academic Google Scholar I. Peral Martinez, I. Peral Martinez Pathology Services, University Hospital, Valladolid, Spain Search for other works by this author on: Oxford Academic Google Scholar M. García Muñoz M. García Muñoz Dermatology and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 3, 1 September 2000, Pages 628–631, https://doi.org/10.1111/j.1365-2133.2000.03723.x Published: 01 September 2000
Cystometry
Authors: J. Lapides
Journal: JAMA (1967)

One of the most important facets in the diagnostic work-up of a patient with urinary tract difficulty is the evaluation of the act of micturition. The significance of abnormalities in micturition can be readily comprehended when one realizes that most urinary tract infections,<sup>1</sup>urinary incontinence, and many cases of pyelonephritis and hydronephrosis are due to dysfunction of the urethra and bladder. In order to pinpoint the cause of a given urinary tract disorder it is necessary to perform (in addition to obtaining the complete history and giving a physical examination at admission) cystoscopy, urethroscopy, pyelography, cystourethrography, urethral calibration, and cystometry. A urological examination without cystometry is disquietingly incomplete, for some entities can be diagnosed only with the use of the cystometer, such as lesions of the corticoregulatory tracts leading to pollakiuria, urgency, enuresis, and urinary tract infection<sup>1</sup>; or sacral spinal-cord defects resulting in partial or complete urinary retention,
Villous adenoma of the stomach
Authors: R. J. Ross
Journal: JAMA (1966)

THE VILLOUS ADENOMA is an important tumor of the gastrointestinal tract. Since Sunderland and Binkley<sup>1</sup>described a series of cases of villous adenomas of the colon in 1948, many reports of these tumors have appeared in the literature. More recently, the villous adenoma of the duodenum has been described.<sup>2,3</sup>There are reports of villous tumors of the stomach in the French-language literature.<sup>4-7</sup>This communication is a case report of a villous adenoma of the stomach. <h3>Report of a Case</h3> A 62-year-old white woman had had vague upper abdominal pain for several weeks. There was no history of vomiting, hemoptysis, melena, or weight loss. Findings of the physical examination were not contributory. A study of the upper gastrointestinal tract showed a polypoid, irregular filling defect in the body of the stomach at the incisura angularis ventriculi (Fig 1). There was no evidence of a lack of distensibility of
Institutional care of the mentally subnormal
Authors: T. McKeown, I. Leck
Journal: BMJ (1967)

BRITISBThe observation that the fasting serum folate activity remained low does not disprove that the haematological response was the result of folate in the diet after admission, as it is possible to treat megaloblastic anaemia without replenishing body folate stores.3Any relationship between folate metabolism and ascorbic acid remains obscure, but it has been shown that patients with only slight evidence of folate deficiency may become frankly megaloblastic when treated with ascorbic acid alone and a folic acid-free diet.4 5 The contradictory reports of ascorbic acid converting megaloblastic erythropoiesis to normoblastic and normoblastic erythro- poiesis to megaloblastic are probably explained by the former studies not being conducted on folate-free diets, and by an increased utiliza- tion and low intake of folate in the latter.As a patient who has scurvy is likely to be folate-deficient, it seems sensible to give folic acid to all scorbutic patients and also to ensure that they are not deficient of vitamin B12 and iron.-Weare, etc.,
Decreased PPARγ Expression Compromises Perigonadal-Specific Fat Deposition and Insulin Sensitivity
Authors: Yau-Sheng Tsai, Pei-Jane Tsai, Man-Jin Jiang, Ting-Yu Chou, Avani Pendse, Hyung-Suk Kim, Nobuyo Maeda
Journal: Endocrine Reviews (2009)

Mutations and polymorphisms in PPARG have been linked to adiposity and partial lipodystrophy in humans. However, how disturbances in PPARG lead to depot-specific effects on adipose tissue, as shown by the characteristic aberrant fat distribution in patients, remains unclear. By manipulating the 3′-untranslated region of the Pparg gene, we have generated mice with peroxisome proliferator-activated receptor γ (PPARγ) gene expression ranging from 25% to 100% normal. Basal levels of PPARγ transcripts between 50% and approximately 100% had no significant effect on body weight, fat mass, and insulin sensitivity. In contrast, mice with 25% normal PPARγ expression exhibited reduced body weight and total fat mass, insulin resistance, and dyslipidemia. Interestingly, fat mass was selectively reduced in perigonadal depot without significant changes in inguinal and other depots. Expression of adipogenic factor CCAAT enhancer binding protein-α and some other metabolic genes containing peroxisome proliferator response element were reduced in a perigonadal depot-specific fashion. This was further associated with depot-specific reduction in the expression of adipokines, increased expression of TNFα, and increased ectopic lipid deposition in muscles. Together, these results underscore the differential sensitivity of the individual fat depots on PPARγ availability as an underlying mechanism of partial lipodystrophy.