tbuckley/cabot-search huggingface dataset:
Is prostate-specific antigen progression a surrogate for objective clinical progression in early prostate cancer?
Authors: D. Newling, K. Carroll, T. Morris
Journal: Journal of Clinical Oncology (2004)

4652 Background: It is a common misconception that a correlation between endpoints is enough to demonstrate surrogacy. To show true surrogacy, the effect of an intervention on an intermediate endpoint relative to a control treatment needs to reliably predict the effect of the intervention on the clinical outcome of interest. Valid surrogate endpoints are needed to accelerate availability of information about new therapies for early prostate cancer where clinical progression and survival times are prolonged. The usefulness of prostate-specific antigen (PSA) progression as a surrogate for objective clinical progression has therefore been assessed in the bicalutamide ('Casodex') Early Prostate Cancer (EPC) Program, the world's largest prostate cancer treatment program. Methods: Individual data from all 8113 patients across 21 countries in the EPC Program were examined. Time to PSA progression and time to objective clinical progression were the endpoints evaluated. The effect of treatment on time to PSA progression was compared with the effect of treatment on time to objective clinical progression. Results: Analyses suggest that time to PSA progression is a modest surrogate endpoint for the effect of a hormonal intervention on objectively confirmed progression in patients with early prostate cancer (r2 = 0.52–0.65, p<0.001). An intervention that produces around a 50% reduction in the risk of PSA progression would likely result in around a 20% reduction in the risk of objective clinical progression. Conclusions: The effect of treatment on PSA progression is moderately predictive for the effect of hormonal treatment on objective clinical progression. A large effect on PSA progression predicts for a smaller, but nonetheless clinically important effect on objective clinical progression. These data suggest that a large positive treatment effect on time to PSA progression is reasonably likely to reflect a clinically important delay in objective clinical progression, making PSA progression a valid endpoint for the evaluation of hormonal medicines in early prostate cancer. 'Casodex' is a trademark of the AstraZeneca group of companies. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca AstraZeneca AstraZeneca
Listeria monocytogenes meningitis in a transplant recipient
Authors: E. E. Etheredge
Journal: JAMA (1975)

RENAL transplantation, which is performed in more than 120 institutions in this country, creates an enlarging patient population with susceptibility to infectious diseases that have been seen uncommonly except in association with debilitating conditions such as cancer and its chemotherapy. As increasing numbers of transplant recipients return for long-term care by an assortment of nephrologists, internists, urologists, and general surgeons, an awareness of the unusual infections to which they fall victim is required, as well as a reemphasis on the fact that they may have more than one major infection synchronously. We here report a case of<i>Listeria monocytogenes</i>meningitis that occurred concurrently with<i>Pneumocystis carinii</i>pneumonitis in a transplant recipient. <h3>Report of a Case</h3> An 18-year-old man in chronic renal failure received a renal allograft from his mother on May 6, 1973. After two severe rejections, his maintenance immunosuppression consisted of azathioprine, 250 mg/day, and methylprednisolone (Medrol), 90 mg/day.
Combo Therapy Beats Back Relapsed NSCLC
Journal: Cancer Discovery (2019)

Patients with EGFR-mutant non-small cell lung cancer who develop MET-driven resistance to an EGFR inhibitor-be it a first-, second-, or third-generation drug-stand to benefit from follow-up treatment with a combination of EGFR-targeted osimertinib and MET-blocking savolitinib, according to an interim analysis of two expansion cohorts from the multiarm TATTON trial.
L'aspiro-phare: Capteur d'insectes à rayons ultra-violets:
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smokers' Beliefs About the Health Benefits of Smoking Cessation—20 U.S. Communities, 1989
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GROWTH OF MAMMALIAN CELLS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated Adenosine Signaling Via Adenosine A2B Receptor Induces Normal and Sickle Erythrocyte Sphingosine Kinase 1 Activity
Authors: Kaiqi Sun, Yujin Zhang, Mikhail Bogdanov, William Dowhan, Modupe Idowu, Harinder S. Juneja, Michael R. Blackburn, Rodney E. Kellems, Yang Xia
Journal: Blood (2014)
Table of Contents
Authors: Detlef Schlöndorff, Jai Radhakrishnan, Christina Wyatt, Bertram Kasiske, David Harris, Tilman Drüeke, Jürgen Floege, Thomas Rauen, Dong Zhou, Youhua Liu, Katarzyna Jobin, Christoph Heuser, Christian Kurts, Frédéric Houssiau
Journal: Kidney International (2016)
ENDOCARDITIS IN ITS RELATIONS TO OTHER DISEASES.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ADAPTATION OF INFANT WELFARE WORK TO PRIVATE PRACTICE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prolonged pregnancy.
Journal: BMJ (1969)

~Leading Articles BmRTISH 703normal or subnormal levels of serum vitamin B1E after partial gastrectomy are much more common than those with overt megaloblastic anaemia.6The vitamin-B12 deficiency is due to a failure of secretion of intrinsic factor as a consequence of atrophic gastritis in the gastric remnant,7 and only in a small minority of cases is a blind-loop syndrome to blame.In the Scandinavian cases of " myelopathy " the average time elapsing between operation and the onset of neurological symptoms was more than 10 years.Such a long latent interval need occasion no surprise if vitamin-B12 deficiency is responsible, for impairment of intrinsic factor secretion would take time to develop from atrophic gastritis in the gastric remnant, and the hepatic store of vitamin B1, would also have to become depleted.The recent report from Birmingham2 suggests that neuro- logical disease after gastrectomy may be more complex than was thought at first and that vitamin-B12 deficiency may not invariably be responsible.Serum levels of vitamin B12 were
Pulmonary Meningioma
Authors: MARCO CURA, WILLIAM SMOAK, RAYMUND DALA
Journal: Clinical Nuclear Medicine (2002)

An intraparenchymal lung tumor exhibiting the histopathologic and immunophenotypic characteristics of an intracranial meningioma is described. The tumor presented as a solitary asymptomatic pulmonary nodule with increased fluorodeoxyglucose uptake on positron emission tomography. After right upper lobectomy, benign psammomatous meningioma was diagnosed. There was no clinical or radiographic evidence of a central nervous system tumor, suggesting that this was a primary lung tumor. The authors describe a benign tumor that can present as a false-positive finding of positron emission tomography performed to evaluate a possible malignant pulmonary nodule.
Practical Considerations of Venous Pressure
Authors: Hugh Hudson Hussey, Harold Jeghers
Journal: New England Journal of Medicine (1947)

Diagnostic Value of Regional Differences in Venous PressureIn the older literature on venous pressure almost the entire interest centered on values obtained by determination of the venous pressure in one arm. In recent years, it has been demonstrated that comparison of pressure in various peripheral tributaries of the inferior and superior vena cavae greatly increases the diagnostic value of venous-pressure measurements for certain types of disease. Although the literature on the diagnostic significance of regional differences in venous pressure is somewhat limited, the value of this technic is strongly indicated by those who have used it. One can predict . . .
Models of Interaction between Metabolic Genes and Environmental Exposure in Cancer Susceptibility
Authors: Emanuela Taioli, Carlo Zocchetti, Seymour Garte
Journal: Environmental Health Perspectives (1998)

Polymorphic metabolic genes that confer enhanced genetic susceptibility to the carcinogenic effects of certain environmental carcinogens act according to a type 2 interaction between genetic and environmental risk factors. This type of interaction, for which the gene has no effect on disease outcome by itself but only modifies the risk associated with exposure, must be treated differently from other types of gene-environment interaction. We present a method to analyze different dose effects often seen in studies involving these genes. We define a low exposure-gene effect, when a greater degree of gene environment interaction appears at lower doses of exposure (the interaction follows an inverse dose function), and a converse high exposure-gene effect, when the interaction increases as a function of dose. Using a standard logistic regression model, we define a new term, alpha, that can be determined asa function of exposure dose in order to analyze epidemiological studies for the type of exposure-gene effect. These models are illustrated by the use of hypothetical case-control data as well as examples from the literature.
Abstract 1940: Comparison of anti-hepatocellular carcinoma efficacy between regorafenib and sorafenib using multimodality molecular imaging: A preclinical study
Authors: Yang Du, Jie Tian
Journal: Cancer Research (2019)

Abstract Purpose: Sorafenib has been used as a targeted therapy for HCC for more than a decade, and regorafenib has recently been approved for HCC treatment and shown to prolong survival for advanced HCC patients after treatment failure with sorafenib. However, there has been no systematic study to directly compare the therapeutic effects of regorafenib and sorafenib against HCC. In this study, we systematically compared the therapeutic effects of sorafenib and regorafenib against HCC in vitro and in vivo using multimodality molecular imaging. Experimental Design: we systemically investigated and compared the anti-tumorigenic and anti-angiogenic efficacy of regorafenib and sorafenib in vitro and in vivo using multi-modality molecular imaging as bioluminescence imaging (BLI), bioluminescence tomography (BLT), fluorescence molecular imaging (FMI), and computer tomography angiography (CTA) etc. Moreover, the safety and side effects of two drugs were simultaneously systemically evaluated. Results: The results showed that compared with sorafenib treatment, regorafenib exerted stronger antitumor and antiangiogenic effects and significantly increased the survival rate of HCC model mice. Although both drugs caused side effects, their severity was usually higher with sorafenib, except that regorafenib caused hypertension, which was not observed with sorafenib. Conclusions: The study suggests that multimodality molecular imaging can help sensitively evaluate the drug treatment efficacy against HCC before tumor anatomical changes occur and also helps understand the underlying antitumor mechanism of a drug at the molecular and cellular levels. Our data may provide an experimental basis for clinical application of HCC targeted treatment with regorafenib and sorafenib. Citation Format: Yang Du, Jie Tian. Comparison of anti-hepatocellular carcinoma efficacy between regorafenib and sorafenib using multimodality molecular imaging: A preclinical study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1940.
A Diffusion Tensor Imaging Study of Fasciculi in Schizophrenia
Authors: Sukhwinder S. Shergill, Richard A. Kanaan, Xavier A. Chitnis, Owen O’Daly, Derek K. Jones, Sophia Frangou, Steven C.R. Williams, Robert J. Howard, Gareth J. Barker, Robin M. Murray, Philip McGuire
Journal: American Journal of Psychiatry (2007)

Objective: Cognitive models propose that the symptoms and psychological impairments associated with schizophrenia arise as a consequence of impaired communication between brain regions, especially the prefrontal cortex and the temporal and parietal lobes. Functional imaging and electrophysiological data have provided evidence of functional dysconnectivity, but it is unclear whether this reflects an underlying problem with anatomical connectivity. This study used diffusion tensor imaging to examine the integrity of the major white matter fasciculi, which connects the frontal and temporal-parietal cortices, and the corpus callosum in patients with schizophrenia. Method: A 1.5-T magnetic resonance scanner was used to acquire diffusion tensor images giving whole brain coverage at an isotropic 2.5-mm voxel size. Fractional anisotropy was measured in 33 patients with schizophrenia and 40 healthy comparison subjects with an automated voxel-based method of analysis. Results: There was reduced fractional anisotropy in patients with schizophrenia in regions corresponding to the superior longitudinal fasciculi bilaterally and in the genu of the corpus callosum. However, within the patient group, the propensity to experience auditory hallucinations was associated with relatively increased fractional anisotropy in superior longitudinal fasciculi and in the anterior cingulum. Conclusions: Schizophrenia is associated with altered white matter integrity in the tracts connecting the frontal cortex with the temporal and parietal cortices and with the contralateral frontal and temporal lobes. The severity of these changes may vary with the pattern of symptoms associated with the disorder.
THE MICROBE OF OROYA FEVER
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PD-1 Blockade in GBM: Uncovering Response Clues
Journal: Cancer Discovery (2019)

Although glioblastoma multiforme is generally considered unresponsive to immunotherapy, findings from three recent studies provide molecular clues that may help clinicians figure out which patients are more likely to benefit from this treatment. The results also suggest that the timing of PD-1 blockade may be critical in promoting therapeutic efficacy.
Should phonocardiography be abandoned?
Authors: Robert J. Adolph, Beatrice J. Argano, Ernest Craige, James J. Leonard, Aldo A. Luisada, David H. Spodick, Morton E. Tavel, Howard H. Wayne, Arnold M. Weissler
Journal: JAMA (1979)

IN JUNE 1977, the Blue Shield Association announced that Blue Shield plans would discontinue routine payment for several diagnostic procedures because they were considered generally unnecessary. Phonocardiography was listed among those procedures, along with pulse tracings and apex cardiograms. This Program on Medical Appropriateness is already being implemented by most carriers, including Medicare and insurance companies. Thus, many patients may be deprived of the use of this method although they may be studied by means of other procedures, some of which are more costly or more dangerous. An official letter of disagreement with this policy on phonocardiography was drafted by the officers of the Laënnec Society, passed by the membership, and sent to the Council on Clinical Cardiology of the American Heart Association with a recommendation that the association petition Blue Shield to reevaluate their decision with the advice of experts. Several noninvasive methods of study of the cardiac function,
Early diastolic flow propagation velocity (Vp) during dobutamine stress echocardiography (DSE) Takahiro Ohara, Yuji Hashimoto, Akihiko Matsumura, Kenichi Hurumi, Ryoji Watanabe, Tomoyuki Watanabe, Ryoko Wakizono. Kameda Medical Center, Chiba prefecture, Japan
Journal: Journal of the American College of Cardiology (2001)
Proceedings of the Thoracic Society
Journal: Thorax (1971)

EMPHYSEMAGenetic Aspects of Alpha-i Antitrypsin P. J. L. COOK At present nine different alleles are known in the Pi system producing 45 theoretically possible electrophoretic patterns on starch gel electrophoresis.So far 18 of these patterns have been seen and the subject has been reviewed by Fagerhol and Laurell (1970).The frequency with which different Pi genotypes occur in the population of Great Britain has been investigated and it is estimated that about 3% of this population are of Pi type MZ, that is 'carriers' of the gene producing alpha-i antitrypsin deficiency.Pi type MS also occurs in about 5% of this population.Indi- viduals with two S alleles produce less antitrypsin than those with two M alleles but more than those with two Z alleles.The concentration of alpha-i antitrypsin present in the plasma depends not only upon the individual's genotype but also upon his state of health.Such environmental variation coupled with certain theoretical con- siderations makes the biochemical diagnosis of 'carriers' difficult.Studies on the normal population show that approximately one baby in 5,000 is born in England with a deficiency of alpha-i antitrypsin (Pi type ZZ).But family and population studies suggest that it is by no means inevitable that he will suffer from chest or liver disease during his lifetime.