tbuckley/cabot-search huggingface dataset:
Networks
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevention of venous thrombosis with small, subcutaneous doses of heparin
Authors: A. S. Gallus
Journal: JAMA (1976)

The effect of low-dose heparin prophylaxis on venous thrombosis and bleeding after major elective surgery was studied in a prospective controlled study of 820 patients. The total incidence of venous thrombosis detected with leg-scanning using fibrinogen labeled with radioactive iodine (<sup>125</sup>I) was reduced from 16.0% in the control group to 4.2% in treated patients. More important, the incidence of popliteal or femoral vein thrombosis was reduced from 2.9% to 1.0%. Prophylaxis resulted in a slight increase in bleeding—minor wound hematoma, mean volume of blood transfused, and a postoperative hematocrit fall in treated patients. However, increased bleeding was clinically minor, and prophylaxis was well tolerated. (<i>JAMA</i>235:1980-1982, 1976)
Arthritis Awareness Month — May 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Doctor-diagnosed arthritis is a common chronic condition that affects approximately 52.5 million (22.7%) adults in the United States and is a leading cause of disability (1,2).The prevalence of doctor-diagnosed arthritis has been well documented at the national level (1), but little has been published at the state level and the county level, where interventions are carried out and can have their greatest effect.To estimate the prevalence of doctor-diagnosed arthritis among adults at the state and county levels, CDC analyzed data from the 2014 Behavioral Risk Factor Surveillance System (BRFSS).This report summarizes the results of that analysis, which found that, for all 50 states and the District of Columbia (DC) overall, the age-standardized median prevalence of doctor-diagnosed arthritis was 24% (range = 18.8%-35.5%).The age-standardized model-predicted prevalence of doctordiagnosed arthritis varied substantially by county, with estimates ranging from 15.8% to 38.6%.The high prevalence of arthritis in all counties, and the high frequency of arthritisattributable limitations (1) among adults with arthritis, suggests that states and counties might benefit from expanding Continuing Education examination available at http://www.cdc.gov/mmwr/cme/conted_info.html#weekly.
Principles of Hygiene.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Physician's Pocket Account Book,
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases of Women
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reproductive and Developmental Toxicity of Toluene: A Review
Authors: James M. Donald, Kim Hooper, Claudia Hopenhayn-Rich
Journal: Environmental Health Perspectives (1991)

Toluene is a widely used industrial solvent, and humans may also have high exposures to toluene from the deliberate inhalation ("9miffn") of paint reducer, paint thiner, or paint for their narctic effects.A number ofcase reports describe neonatal effects that have been attributed to ohiene abuse during p .These effects may include intratrn grwth retardation, premature delivery, congenital malformations, and postnatal developmental retardation.The possibility of exposures to other fetotoxic agents, either as inpurities or admixt in toluene-containing products, or by deliberate or accidental expouers to other chemcals or drugs, cannotbeexcluded in these cases.The fetotoxic effects oftoluene have been demonstrated in controlled studies in animals and are comparable to those observed in humans who have abused toluene-containing products before or during pregnancy.Intrauterine developmental retardation is the most clearly established effect in animals, as evidenced by decreased late fetal weight and rearded skeletal development.There is also limited evidence in rodents for skeletal and kidney abnormaltes, as weli as some evidence for effects on postnatal phycl and possibly neurobehavioral development.ted daily expsr from experimental studies in animals are compared to estimated human dailly intakes at the occupational permissible exposure level and at the level reported to produce euphoria in humans.Acceptable human intakes under California's Proposition 65 and under U.S. Environmental Pro- tection Agency procedures are discussed.
Abstract LB-113: MAPK pathway suppression unmasks latent DNA repair defects and confers a chemical synthetic vulnerability in<i>BRAF</i>,<i>NRAS</i>and<i>NF1-</i>mutant melanomas
Authors: Ophélia Maertens, Ryan Kuzmickas, Haley Manchester, Chloe Emerson, Alessandra Gavin, Caroline Guild, Terence Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi Garraway, Keith Flaherty, Shailja Pathania, Stephen Elledge, Karen Cichowski
Journal: Cancer Research (2019)

Abstract While the majority of BRAF-mutant melanomas respond to BRAF/MEK inhibitors, these agents are not typically curative. Moreover, they are largely ineffective in NRAS and NF1-mutant tumors. Here we report that genetic and chemical suppression of HDAC3 potently cooperates with MAPK pathway inhibitors in all three Ras pathway-driven tumors. Specifically, we show that entinostat dramatically enhances tumor regression when combined with BRAF/MEK inhibitors, both in models that are sensitive or relatively resistant to these agents. Interestingly, MGMT expression predicts responsiveness and marks tumors with latent defects in DNA repair. BRAF/MEK inhibitors enhance these defects by suppressing homologous recombination genes, inducing a BRCA-like state; however, entinostat addition triggers the concomitant suppression of NHEJ genes, resulting in a chemical synthetic lethality caused by excessive DNA damage. Together these studies identify melanomas with latent DNA repair defects, describe a promising drug combination that capitalizes on these defects, and reveal a tractable therapeutic biomarker. Citation Format: Ophélia Maertens, Ryan Kuzmickas, Haley Manchester, Chloe Emerson, Alessandra Gavin, Caroline Guild, Terence Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi Garraway, Keith Flaherty, Shailja Pathania, Stephen Elledge, Karen Cichowski. MAPK pathway suppression unmasks latent DNA repair defects and confers a chemical synthetic vulnerability inBRAF,NRASandNF1-mutant melanomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-113.
WHY ARE SCIENTISTS POOR WRITERS?
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcohol lowers risk of heart disease through effect on lipids and haemostatic factors
Journal: BMJ (1999)

Alcohol lowers risk of heart disease through effect on lipids and haemostatic factors Results from observational studies provide strong evidence that people who drink moderate amounts of alcohol have a lower risk of developing coronary heart disease than those who abstain, but some have suggested that this association is spurious.Rimm et al (p 1523) conducted a meta-analysis of all experimental studies of alcohol intake to summarise the effects of alcohol on lipid and haemostatic factors and to explain the inverse association between alcohol intake and risk of coronary disease.With an alcohol intake of 30 g a day the authors project a 24.7% reduction in risk of coronary heart disease mediated through changes in concentrations of high density lipoprotein cholesterol, fibrinogen, and triglyceride.
<i>Epitome of Mental Diseases, with the Present Methods of Certification of the Insane, and the Existing Regulations as to "Single patients," for Practitioners and Students.</i>By James Shaw, M. D., Qu. Univ., Irel., Master of Surgery; Member the Medico-Psychological Association; Formerly Medical Superintendent and Colicensee, Haydock Lodge Asylum, Lancashire; Assistant Medical Officer, Grove Hall Asylum, Bow, London; Assistant Medical Officer, Norfolk County Asylum. New York: E. B. Treat, 5 …
Journal: American Journal of Psychiatry (1893)
Acute Glomerulonephritis
Authors: Jerome P. Kassirer, William B. Schwartz
Journal: New England Journal of Medicine (1961)

In the past decade significant contributions have been made to the understanding of acute glomerulonephritis by virtue of advances in many fields, including epidemiology, immunology, histopathology and cardiovascular physiology. In addition, a variety of careful clinical observations have clarified many aspects of the natural history of the disease. Accordingly, a critical summary of these new data and an analysis of their clinical implications seem both desirable and timely.EpidemiologyIt has long been known that acute glomerulonephritis, like acute rheumatic fever, often follows infections with beta-hemolytic streptococci, but many features of its epidemiology have until recent years been poorly understood. . . .
Rubella-Vaccinated Students
Authors: Gilbert M. Schiff
Journal: JAMA (1978)

In a 7 1/2-year follow-up evaluation of the duration of rubella-vaccine-induced immunity of students who received either HPV-77 DK-12 or Cendehill vaccine, both groups showed a continuous decline in hemagglutination-inhibition antibody from seven weeks after vaccination but a lower decline between 4 1/2 and 7 1/2 years after vaccination. However, at 7 1/2 years only 16 students (8%) receiving the Cendehill vaccine and one student (0.5%) receiving the HPV-77 DK-2 vaccine lacked detectable antibody. Despite the persistence of antibody titers, there was evidence of subclinical rubella among both groups of vaccinated students. These results emphasize the importance of continued evaluation of the conditions of persons receiving rubella vaccine. (<i>JAMA</i>240:2635-2637, 1978)
Quality of Care in Medicaid Managed Care vs Commercial Managed Care Plans
Authors: Dawn Wood, Darius Jatulis
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood, New York
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1951)

really entail a journey of four miles from doctor's tesidence to patient's, a state of affairs that could only normally exist once it is determined that carrying coals to Newcastle is a vital principle of economics, he will perhaps realize that his rural colleagues who have a list of between 1,000 and 1,500 with no hope ever of increasing it, but which nevertheless entails the same working hcurs as an urban doctor with a list of around 4,000, rely on the mileage fund these days for about 40% of their income, and are very jealous of encroachment upon it by their urban neighbours.-I am, etc.,
Abstract B26: Baseline serum albumin as a prognostic actor in patients with stage I and II colon adenocarcinoma
Authors: Sagrario Gonzalez-Trejo, Jose F. Carrillo, Doris Carmona-Herrera, Roberto Herrera-Goepfert, Francisco J. Ochoa-Carrillo, Vincenzo Aiello-Crocifoglio, Dolores Gallardo-Rincon, Luis F. Onate-Ocana
Journal: Cancer Research (2017)

Abstract Background: Patients with stage I or II Colon carcinoma (CC) have a significant risk of recurrence after adequately performed curative resection. Adjuvant chemotherapy has not improved recurrence or survival in such patients. In this study, a prognostic model in patients with stage I or II CC, based on Baseline serum albumin (BSA) and other common clinical markers is presented. Methods: Consecutive cases with CC treated at a single cancer center in Mexico City from January 1998 to December 2014, with diagnosis of adenocarcinoma by colonoscopy and biopsy were included in this cohort. Clinical history and chemistry data were registered, and patients were treated according to standard guidelines. Follow-up continued until June 2016; the Kaplan-Meier method and the Cox model were used to analyze the association of prognostic factors and overall survival (OS), and Hazard ratios (HR) were calculated. Results: 1,259 cases of CC were treated, but only 496 patients have stage I and II CC and were included in the database: 234 women (47.2%) and 262 males (52.8%) and their mean age was 59.9 years (SD 14.9); 96, 339, 31 and 30 cases were pTNM stages I, IIa, IIb and IIc, respectively. BSA (HR 2.185), male gender (HR 1.43), baseline hemoglobin (HR 0.916), baseline platelet count (HR 0.998), baseline neutrophil count (HR 1.085), albumin/globulin ratio (HR 0.197), baseline platelet/lymphocyte ratio (HR 1.001), body mass index (HR 0.958), TNM stages (IIa HR 1.74, IIb HR 2.08, IIc HR 2.59; Stage I is the reference category), use of adjuvant chemotherapy (HR 0.465) and R classification (R1 HR 1.306, R2 HR 2.55, no resection HR 6.93; R0 is the reference category). Predicted survival functions using this model, defined 4 risk groups that showed better prognostic value than simple TNM stages I-IIc. Conclusion: BSA is an independent, significant, simple, cheap and widely available prognostic factor in patients with CC. BSA and other clinical factors add significant prognostic information to TNM classification. Feasibly, it can be used to develop multivariate prognostic models with clinical impact defining the use of adjuvant chemotherapy. The use of histopathological and immunohistochemical markers could improve the prognostic information of this model. Citation Format: Sagrario Gonzalez-Trejo, Jose F. Carrillo, Doris Carmona-Herrera, Roberto Herrera-Goepfert, Francisco J. Ochoa-Carrillo, Vincenzo Aiello-Crocifoglio, Dolores Gallardo-Rincon, Luis F. Onate-Ocana. Baseline serum albumin as a prognostic actor in patients with stage I and II colon adenocarcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer: From Initiation to Outcomes; 2016 Sep 17-20; Tampa, FL. Philadelphia (PA): AACR; Cancer Res 2017;77(3 Suppl):Abstract nr B26.
Heberden Society
Journal: Annals of the Rheumatic Diseases (1960)

Familial Aggregation in Generalized Osteo-Arthrosis.J. S. LAWRENCE (Manchester): First-degree relatives of persons with osteo-arthrosis in six or more joints dis- covered in population studies were examined clinically and radiologically and their serum was tested for rheu- matoid factor.An increased prevalence of both generalized osteo- arthrosis and sero-negative inflammatory polyarthritis was found in these relatives.This study suggested the possibility of two main types of generalized osteo- arthrosis.Dicussion.-DR.W. S. TEGNER (London) said that Hench had been interested in osteo-arthrosis.In 1938 he x-rayed all the joints in the body of an old lady of 104 years and found no osteo-arthrosis.None of her family had died below the age of 80.He x-rayed some of them and found no osteo-arthrosis in them either.He also x-rayed one or two other families of centenarians with the same results.When asked why he did not
Acute promyelocytic leukemia presented as a relapse of acute myeloid leukemia
Authors: Aneta Manda-Handzlik, Candida Vitale, Elias Jabbour, Xinyan Lu, Mariko Yabe, Rashmi Kanagal, Naval Daver, Naveen Pemmaraju, Carlos Bueso-Ramos, Koichi Takahashi, S Rajkumar, Ajh Ajh
Journal: American Journal of Hematology (2016)