tbuckley/cabot-search huggingface dataset:
Sodium butyrate reversibly blocks mouse hepatocytes early in G1 and inhibits the spontaneous expression of p53 and CDK4 INSERM U-49, H�pital Pontchaillou, Rennes 35033, France
Journal: Hepatology (1995)

Proliferating lipocytes (fat-storing cells or perisinusoidal stellate cells of the liver) were detected by in vivo incorporation of bromodeoxyuridine (BrdU) in an experimental model of cirrhosis in the rat by dimethylnitrosamine. Lipocytes were identified by sequential double immunohistochemical staining on frozen sections using anti-desmin antibodies as a marker of cytoplasmic intermediate filaments followed by anti-BrdU antibodies to identify S-phase nuclei in animals treated for 7, 14 or 21 days. The number of desmin-positive (lipocytes) and desmin-negative (Kupffer and endothelial cells) sinusoidal cells incorporating BrdU was recorded. The labelling index of lipocytes was calculated as the percentage of BrdU-labelled desmin-positive cells with respect to total number of lipocytes. In control animals, when the total number of lipocytes was 153.9 ± 11/mm2 (mean ± 1 S.E.) the number of desmin-posilive S-phase sinusoidal cells never exceeded 6.8 ± 1.2/mm2 with a maximum labelling index of 4.3 ± 0.5%. At 7 days of treatment, the values were respectively 236 ± 26.5/mm2, 53.2 ± 5.9/mm2 and 22.6 ± 0.5% (p < 0.001 vs. controls), while, at 21 days they were 272.5 ± 21.2/mm2, 23.3 ± 4.0/mm2 and 8.5 ± 1.1% respectively (p < 0.01). These results show that hyperplasia of lipocytes represents an early reaction to dimethylnitrosamine-induced liver injury. The local accumulation of lipocytes appear to occur in areas where fibrous septa develop later on.
Correction
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inclusion body beta-thalassemia trait in a Swiss family is caused by an abnormal hemoglobin (Geneva) with an altered and extended beta chain carboxy-terminus due to a modification in codon beta 114
Authors: P Beris, PA Miescher, JC Diaz-Chico, IS Han, A Kutlar, H Hu, JB Wilson, TH Huisman
Journal: Blood (1988)
Experiments in transgenic mice show that hepatocytes are the source for postnatal liver growth and do not stream*1
Authors: S KENNEDY
Journal: Hepatology (1995)

One hypothesis is that postnatal liver growth involves replication of mature hepatocytes, which have an unlimited proliferative potential. An alternative viewpoint is that only certain periportal cells can replicate extensively and that daughter cells stream slowly from the periportal to the pericentral region of the liver. Transgenic mice expressing the beta-galactosidase (β-gal) gene from the human al antitrypsin promoter were used to examine the proliferative potential of hepatocytes. Surprisingly, only 10% of hepatocytes in two different transgenic lines stain blue with X-gal. In neonatal animals, singlets or doublets of expressing cells are randomly scattered throughout the liver. Although the overall frequency of blue cells is similar in older animals, these cells are present in much larger clusters, suggesting that individual expressing cells have replicated to form a clonally derived cluster. Expression patterns are not altered by the administration of an acute phase stimulus or by the performance a partial hepatectomy, suggesting that the expression state cannot be easily altered, and making it more likely that the expression state is indeed fixed. These results suggest that the clusters of blue cells are clonally derived in the transgenic mice. They argue that the parenchymal hepatocyte is responsible for growth in the postnatal liver and that streaming of liver cells does not occur.
Organic dust toxic syndrome: animal house fever?
Authors: B. B. Dan
Journal: JAMA (1987)

During an average lifetime, the lungs will expand and contract some 500 million times and will be exposed to billions of liters of inspired air—and everything that it contains. Not surprisingly, exposure to particulate matter can cause a multitude of pulmonary problems—the thousand natural shocks that flesh is air to. Most of these illnesses are the result of immunologic reactions to a variety of inhaled antigens including bacteria, fungi, protozoa, and plant or animal proteins. Excluding actual infections, most of these events have been grouped under the category referred to as<i>hypersensitivity pneumonitis</i>. Although hypersensitivity pneumonitis had been recognized as a potential consequence of an occupational exposure since the early 18th century, it was only 50 years ago that a direct relationship was demonstrated between the onset of a respiratory illness in farmers and their exposure to moldy hay.<sup>1</sup>Since then, that particular entity and other reactions from acute exposures
On blowing one's mind (19th-century style). A modest proposal
Authors: L. R. Agnew
Journal: JAMA (1968)

A few years ago I chanced upon a curious little book with the engaging, albeit long-winded, title of<i>The Chemical Experimentalist; or, an attempt to allure by Experiment, and guide by Reasoning, the enquirer after Rational Amusement and Useful Knowledge, Towards the cultivation of the simple and sublime Science—Chemistry</i>. This work is a remarkable hodge-podge of chemical experiments that one can perform at home, hints on cleaning silver and dying cloth, and even a section on the Philosophy of Nature wherein the author solemnly declares, inter alia, "that comets are male planets, and that their tails are their generative organs." That a comet might possess a phallus and could thus presumably indulge in venery on a celestial scale is an intriguing enough notion, but to my mind the most entertaining item in the<i>Chemical Experimentalist</i>is the apparently serious suggestion that nitrous oxide could replace alcohol as a social stimulant.
THE ANTIRACHITIC VITAMIN
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibiotics in surgical treatment of acute abscesses.
Authors: P W Blick, M W Flowers, A K Marsden, D H Wilson, A T Ghoneim
Journal: BMJ (1980)

A four-way, double-blind, prospective trial of treatment of abscesses by incision, curettage, and primary closure with and without antibiotic cover (clindamycin injection before operation or capsules after operation, or both) was conducted. There was no appreciable difference in mean healing time between the patients given both the antibiotic injection and the antibiotic capsules and those given the injection and placebo capsules, whereas healing times in those given the placebo injection and antibiotic capsules or placebo only were appreciably longer. Four of the patients who were not given the antibiotic injection developed bacteraemia; one patient who was given the antibiotic injection also developed a bacteraemia, but this was caused by clindamycin-resistant bacteria. These results show that a single injection of an effective antibiotic before operation is sufficient to protect the patient against bacteraemia and permit optimum healing.
Peripherally Delivered Glutamic Acid Decarboxylase Gene Therapy for Spinal Cord Injury Pain
Authors: Jun Liu, Darren Wolfe, Shuanglin Hao, Shaohua Huang, Joseph C. Glorioso, Marina Mata, David J. Fink
Journal: Molecular Therapy (2004)

Neuropathic pain after spinal cord injury (SCI) represents a difficult problem that is commonly refractory to conventional medical management. To determine if spinal release of gamma-amino butyric acid (GABA) could reduce below-level central neuropathic pain after SCI, we constructed a replication-incompetent herpes simplex virus (HSV)-based vector encoding one isoform of human glutamic acid decarboxylase (GAD67). Dorsal root ganglion (DRG) neurons transduced in vitro or in vivo by subcutaneous inoculation produced GAD and released GABA constitutively. T13 spinal cord hemisection resulted in central neuropathic pain manifested by mechanical allodynia and thermal hyperalgesia. Subcutaneous inoculation of the vector into both feet reduced both manifestations of below-level SCI pain; the vector-mediated effect was partially reversed by intrathecal bicuculline or phaclofen at doses that did not affect thresholds in normal or injured uninoculated animals. Vector-mediated GABA release attenuated the increase in spinal calcitonin gene-related peptide immunoreactivity caused by cord hemisection. These results suggest that HSV-mediated gene transfer to DRG could be used to treat below-level central neuropathic pain after incomplete SCI.
Critique and Cavil... (Sneeze II)
Authors: George X. Trimble
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DIFFERENT PROTEINS OF MILK
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human leukocyte antigen A1-B8-DR3-DQ2-DPB1*0401 extended haplotype in autoimmune hepatitis
Authors: K Manabe
Journal: Hepatology (1993)

Genetic susceptibility to autoimmune hepatitis is associated with the human leukocyte antigen haplotype A1-B8-DR3 and DR4. To date, only one study in Japan has considered the human leukocyte antigen DP locus in this disease, and no studies have been reported in whites. In this study we used a series of sequencespecific oligonucleotide probes to determine human leukocyte antigen DPB1 genotypes in 101 unrelated white northern European patients and 105 racially and geographically matched controls. The aims of the study were twofold: first, to determine the degree of DPBencoded susceptibility to autoimmune hepatitis, and, second, to establish whether susceptibility can be extended to include human leukocyte antigen DPB. None of 17 DPB1 alleles was significantly associated with the susceptibility to autoimmune hepatitis. Although one particular seven-locus haplotype AlB8-DRB3*010-DRB1*0301-DQA1*0501-DQB1*02001-DPB1*0401 was significantly associated with the disease (27% vs. 7%, relative risk = 5.14, p < 0.0005), the association with this haplotype was weaker than that for the six-locus haplotype excluding DPB (40% vs. 11%, RR = 5.52, p < 0.0005). When the patients first seen at ages younger than 16 yr (pediatric patients) were considered separately, the greatest relative risk was for the seven-locus haplotype (41% vs. 7%; relative risk = 9.60, p < 0.0005). The results of this study further confirm that major histocompatibility complex–encoded susceptibility to autoimmune hepatitis is located at or close to the human leukocyte antigen DR locus; however, the A1-B8-DR3-DQ2-DPB1*0401 extended haplotype may be important in determining the age of onset and severity of disease. (HEPATOLOGY 1993;18:1334–1337.)
Art
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Diabetic Ketoacidosis
Authors: MICHAEL D. CLAYMAN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 April 1978Treatment of Diabetic KetoacidosisMICHAEL D. CLAYMANMICHAEL D. CLAYMANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-580_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to take issue with a small part of the recent article "Phenformin-Associated Lactic Acidosis: Pathogenesis and Treatment," by Dr. Misbin (Ann Intern Med87:591-595, 1977). Although the administration of bicarbonate in the setting of metabolic acidosis is known to be associated with a paradoxical CSF acidosis (1, 2), the question of clinical relevance of this phenomenon has never been clearly addressed. In fact, careful reading of two of the articles quoted in the Misbin paper indicates that a paradoxical CSF acidosis occurs with treatment of diabetic ketoacidosis regardless of whether bicarbonate is administered; bicarbonate-induced aggravation...References1. POSNERPLUM JF: Spinal fluid pH and neurologic symptoms in systemic acidosis. N Engl J Med 277:605-613, 1967 CrossrefMedlineGoogle Scholar2. ASSALAOKIMANZANOKOZAK JTFG: Metabolic effects of sodium bicarbonate in management of diabetic ketoacidosis. Diabetes 23:405-411, 1974 CrossrefMedlineGoogle Scholar3. OHMANMARLISSAOKIMUNICHOODAPPAKHANNAKOZAK JETCVG: The cerebrospinal fluid in diabetic ketoacidosis. N Engl J Med 284:283-290, 1971 CrossrefMedlineGoogle Scholar1. BERENYIWOLKKILLIP KMT: Cerebrospinal fluid acidosis complicating therapy of experimental cardiopulmonary arrest. Circulation 52:319-324, 1975 CrossrefMedlineGoogle Scholar2. POSNERPLUM JF: Spinal-fluid pH and neurologic symptoms in systemic acidosis. N Engl J Med 277:605-613, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL D. CLAYMANAffiliations: University of California San Diego School of Medicine La Jolla, CA 92093 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1978Volume 88, Issue 4Page: 580-581KeywordsAcidosisBicarbonatesColony stimulating factorLactic acidosisPathogenesis ePublished: 1 December 2008 Issue Published: 1 April 1978 PDF downloadLoading ...
Valvular Heart Disease in <i>Circulation</i> and the <i>Circulation</i> Subspecialty Journals
Journal: Circulation (2012)

The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the articles related to valvular heart disease that were published in Circulation and the Circulation subspecialty journals in 2010 and 2011.
Reply
Authors: S. Handfield-Jones, B.R. Allen, S.M. Littlewood
Journal: British Journal of Dermatology (1986)

Journal Article Reply Get access S. Handfield‐Jones, S. Handfield‐Jones Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: Oxford Academic Google Scholar B.R. Allen, B.R. Allen Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: Oxford Academic Google Scholar S.M. Littlewood S.M. Littlewood Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 114, Issue 5, 1 May 1986, Pages 641–642, https://doi.org/10.1111/j.1365-2133.1986.tb04080.x Published: 01 May 1986
Errata
Journal: Diabetes Care (2007)

Panels A and B of Fig. 4 in the above-listed article were not properly labeled.The correct figure appears below.Figure 4-ROC curves of individual components of metabolic syndrome as markers of insulin resistance.Insulin resistance was defined based on cutoffs of insulin sensitivity (lower 10th percentile) derived from the non-overweight group (cutoffs, blacks: 4.6 mg ⅐ kg Ϫ1 ⅐ min Ϫ1 per U/ml; whites: 4.4 mg ⅐ kg Ϫ1 ⅐ min Ϫ1 per U/ml).AUC, area under the curve; TG, triglycerides.
Primary Prevention of Cancer: Needs and Opportunities for Research
Authors: A. B. Miller
Journal: Environmental Health Perspectives (1995)

Strategies for cancer prevention generally come from observational epidemiology and must include monitoring for the effects of the actions.The measurement-iterative loop allows us to refine our approach to cancer prevention.When available, clinical trials can also provide strategies for control.Exposure-specific strategies are described; these are such things as health promotion and behavior modification, legislative approaches, treatment for addiction, changes in the food supply, chemoprevention, occupational and environmental regulation, immunization, identification of persons with enhanced genetic susceptibility, and improved surveillance systems.For some exposures such as tobacco, zero exposure is the goal.For others, prudent avoidance or exposures as low as reasonably achievable are appropriate approaches.Research on how to impact deeply ingrained lifestyle and cultural factors has high priority.
Retractile Mesenteritis
Authors: C. G. Tedeschi, G. C. Botta
Journal: New England Journal of Medicine (1962)

OUR interest in retractile mesenteritis was first aroused when one of us (C.G.T.) was consulted on an exploratory laparotomy for a suspected tumor in the large bowel. The tumor was not found, and the only significant alteration was that of a large area of thickening and sclerosis at the root of the mesentery.A few months later we were faced with an almost identical situation. At an exploratory laparotomy for small-bowel obstruction, the suspected condition could not be detected, and both mesentery and mesosigmoid displayed areas of increased thickness, fibrosis and scarring. The pathological diagnosis in both these cases was . . .
Pneumothorax following subdiaphragmatic surgery
Authors: W. K. Hamilton
Journal: JAMA (1968)

The following four cases are presented as evidence that "unusual" complications occur with surprising frequency. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 21-year-old man in excellent health was anesthetized for a nephrectomy on the left side. The operation was performed to obtain a kidney for transplant to a sibling. The patient was of small stature and presented no unusual problem for the surgeon or anesthetist. The operation was performed without event with the patient in the lateral position and with the kidney rest elevated. A subcostal incision on the left side was utilized and the 11th rib resected. Anesthesia was accomplished with fluroxene supplemented by tubocurarine chloride. Respiration was manually controlled. Near the termination of the procedure, the surgeon requested hyperinflation of the lungs. This was accomplished easily and revealed nothing unusual. When the incision was closed, atropine sulfate and neostigmine methylsulfate were administered until curarization was satisfactorily reversed. The endotracheal