tbuckley/cabot-search huggingface dataset:
Temporal trends and predictors in diagnosing pathologic node-positive prostate cancer in clinically node-negative patients.
Authors: Ryan Hutten, Matthew Parsons, Christopher Weil, Jonathan David Tward, Nataniel Hernan Lester-Coll, Skyler B Johnson
Journal: Journal of Clinical Oncology (2021)

128 Background: The management of men with pathologically node positive (pN+) prostate cancer (PCa) is controversial. Here, we describe the temporal patterns and predictors of incidental pN+ PCa men with clinically node negative (cN0) PCa. Methods: We performed a retrospective analysis of men with nonmetastatic, cN0, PCa from the National Cancer Database from 2010 to 2017. Clinical factors included in analysis were pretreatment PSA, pre-surgical International Society of Urological Pathology (ISUP) grade group (GG), clinical T-stage, margin status, and number of nodes sampled. Patient demographic factors included in analysis were age, comorbidity index, race, insurance status, and treatment facility type. We performed univariable and multivariable logistic regression to evaluate temporal trends in the rates of cN0,pN+ prostate cancer diagnosed over time. Two-level hierarchical logistic regression was used to identify covariates associated with pN+ disease. Patients were clustered within treatment facilities to account for individual facility practice patterns. Results: We identified 304,234 men with cN0 PCa who underwent radical prostatectomy (RP) between 2010 and 2017. Within this group 10,919 (3.59%) were found to have pN+ disease. During this period, the annual rate of pN+ PCa increased from 2.02% (n=822) in 2010 to 5.12% (n=2,072) in 2017 (p&lt;0.001). On multivariable logistic regression, ISUP GG was most strongly associated with detection of pN+ PCa. Compared to ISUP GG1, GG2 (OR 3.5, p &lt;0.001), GG3 (OR 8.8, p &lt;0.001), GG4 (OR 12.6, p &lt;0.001) and GG 5 (OR 26.5, p &lt;0.001 ) were all significantly associated with pN+ PCa. Over the study period, the rates of pN+ identification increased from 5.5% to 9.4% in men with GG4, and from 13.4% to 19.5% in men with GG5 (p &lt;0.001). Between 2010 and 2017, the rates of RP in GG4 and GG5 similarly increased by 12% and 16%, respectively (p &lt;0.001). Other significant covariates are depicted in Table. 22% of the total variance was explained by inter-facility variation. Conclusions: The proportion of men with cN0 found to have pN+ PCa is increasing over time, with pN+ incidentally found in nearly 1 in 10 men with GG4 and 1 in 5 men with GG5 PCa. GG4 and GG5 are the strongest independent predictors of pN+ disease, while controlling for clinical and demographic factors. As incidental pN+ results in upstaging, often requiring adjuvant treatment with radiation and systemic therapies, these data are useful for informing discussions prior to RP. [Table: see text]
US Sodium Intake Still Too High
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Table of Contents
Authors: Egbert Smit, Jimmy Ruiz, Michael Chan, Roy Strowd, Wendy Cooper, Sylvie Lantuejoul, Mari Mino-Kenudson, Navneet Singh, Sushma Agrawal, Sabita Jiwnani, Divya Khosla, Prabhat Malik, Anant Mohan, Prasanth Penumadu, Kuruswamy Prasad, Meng Qiao, Tao Jiang, Xinyu Liu, Shiqi Mao, Fei Zhou, Xuefei Li, Chao Zhao, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Caicun Zhou
Journal: Journal of Thoracic Oncology (2021)
Failure of topical testosterone in male-pattern alopecia
Authors: R. A. Berger
Journal: JAMA (1968)

It has long been recognized that male hormone is both a prerequisite and an incitant in pattern alopecia occurring in genetically predisposed men.<sup>1-4</sup>The report by Papa and Kligman<sup>5</sup>in 1965 of stimulation of hair growth in common baldness was, therefore, a most startling and unexpected one, on two grounds. First, because no reliably effective topical medication had ever been found previously for this condition: second, because good results were claimed for the very hormone whose systemic action was known to be a necessary condition for this type of baldness to develop. Papa and Kligman were fully aware of the paradoxical implications of their findings and suggested that perhaps the stimulating topical action of the hormone could be explained on the basis of a local pharmacological action on the scalp tissues. They reported the regrowth of coarse terminal hairs in an estimated 10% to 15% of the affected
Measuring hepatitis C viremia in clinical samples: Can we trust the assays?
Authors: J Pawlotsky
Journal: Hepatology (1997)

onstrate HCV replication and to assess HCV clearance duringMeasuring Hepatitis C Viremia and after therapy; 2) pretreatment HCV RNA thresholds predicting the various categories of response to antiviral treat-in Clinical Samples: Can We ments, 1,2 which can be used to tailor therapy to the level of HCV replication; and 3) RNA levels with prognostic value SENSITIVITY Abbreviations: HCV, hepatitis C virus; RT-PCR, reverse-transcriptase polymerase chain reaction; bDNA, branched DNA; CV, coefficient of variation.The performance of the bDNA assay version 2.
Committee on Nursing
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P2.01-11 ALKternate: A Proof of Concept Study in ALK-Rearranged NSCLC Alternating Lorlatinib with Crizotinib After Disease Progression
Authors: M. Itchins, S. Hayes, A. Hudson, V. Howell, S.W.D. Tan, S. Clarke, B. Solomon, N. Pavlakis
Journal: Journal of Thoracic Oncology (2019)
Children in care.
Journal: BMJ (1967)

MEDIBAJURN6~~~~~~~~~~~~~~~~~~~~~~~~~~~~~EiA ORA is now in a position to select the most suitable one for each purpose from the equipment commercially available. Children in CareUntil about 1960 the annual numbers of illegitimate births and of marriages ending in divorce in England and Wales had not shown a distinct trend up or down since the peak years immediately after the second world war.Then in 1961 the rates for both rose sharply, and they have continued to do so.In 19651 the number of illegitimate babies born was 66,249, or 77 per 1,000 total live births, and the number of divorces was 37,785, or 3.1 per 1,000 married population.Since in many cases the welfare of young children is affected, it is no surprise to learn from the latest report of the Children's Department of the Home Office2 that between 1959 and 1966 the total number of children in the care of local authorities and voluntary organizations in England and Wales rose from 78,648 to 79,99%.But some comfort may
THE HEALTH OF THE ARMY IN THE PHILIPPINES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential Effects of Two Lots of Aroclor 1254: Congener-Specific Analysis and Neurochemical End Points
Authors: Prasada Rao S. Kodavanti, Narayanan Kannan, Nobuyoshi Yamashita, Ethel C. Derr-Yellin, Thomas R. Ward, Deborah E. Burgin, Hugh A. Tilson, Linda S. Birnbaum
Journal: Environmental Health Perspectives (2001)

Aroclor 1254 is a widely studied commercial polychlorinated biphenyl (PCB) mixture which, by definition, contains 54% chlorine by weight. Recent reports indicate substantial differences in the congener composition among Aroclor lots and hence their biologic effects. We designed the current study to compare the effects of two lots of Aroclor 1254 (lots 6024 and 124-191). We analyzed these two lots for PCB congeners, polychlorinated dibenzofurans (PCDFs), polychlorinated naphthalenes (PCNs), and polychlorinated dibenzodioxins (PCDDs). We used previously established techniques for analyzing intracellular Ca(2+) buffering and protein kinase C (PKC) translocation to test their biologic activity in neuronal preparations. PCB congener-specific analysis indicated that ortho and non-ortho congeners in these two lots varied in their percent contribution. Among all congeners, the percentages of non-ortho congeners (PCBs 77, 81, 126, and 169) were higher in lot 6024 (2.9% of total) than in lot 124-191 (0.02% of total). We detected no dioxins in these two lots (< 2 ppb). Although there are some differences in the congener composition, total PCNs were similar in both lots: 171 ppm in lot 6024 and 155 ppm in lot 124-191. However, total PCDFs were higher in lot 6024 (38.7 ppm) than in lot 124-191 (11.3 ppm). When we tested these two Aroclors on Ca(2+) buffering and PKC translocation in brain preparations, the effects were significantly different. Although lot 124-191 was more potent on PKC translocation than lot 6024, lot 6024 was slightly more active on Ca(2+) buffering than lot 124-191. These effects could not be attributed to the differences in the percentage of non-ortho congeners or PCDFs because they were inactive on these two parameters. The effects could not be attributed to PCNs because the levels were almost similar. The effects seen with two lots of Aroclor 1254 in neuronal cells were also not predicted based on the TCDD toxic equivalents (TEQs), although TEQs predicted the effects on ethoxyresorufin-O-deethylase (EROD) or methoxyresorufin-O-deethylase (MROD) activities. It is possible that the differential effects seen in neuronal cells could be caused by differences in the composition of ortho-congeners in these two mixtures, because PCBs with ortho-lateral substitutions can exhibit different activities on the selected neurochemical end points. Because of these differential effects with different lot numbers, the composition of Aroclor mixtures used in investigations should be disclosed.
Melanotic macules in Albright's syndrome and in neurofibromatosis
Authors: P. H. Benedict
Journal: JAMA (1968)

The clinical features of the pigmentation in 27 cases of Albright's syndrome and 19 cases of neurofibromatosis were indistinguishable. Microscopic study of split-skin preparations showed giant pigment granules in malpighian cells or in melanocytes, or in both, in normal skin and in café-au-lait spots of 19 patients with neurofibromatosis but in only one of ten patients with Albright's syndrome. This difference was statistically significant (<i>P</i>= &lt;0.01), suggesting a possible means of differential diagnosis. The increase in pigmentation in the macules was not necessarily connected with an increase in the number of melanocytes.
Cancer Screening
Authors: Susan Rosenthal
Journal: JAMA (1996)

"It seems intuitive that cancer screening is beneficial.... Yet despite being an intuitive or reasonable concept, cancer screening remains difficult, controversial, and often confusing." With this beginning, the editors of<i>Cancer Screening</i>, from the H. Lee Moffitt Cancer Center in Tampa, Fla, proceed to make this topic less difficult, less confusing, but probably even more controversial than it was previously in the minds of most readers. In a meticulously documented, clear, and concise fashion,<i>Cancer Screening</i>provides a state-of-the-art description of the role of screening for various types of cancers. In addition, in a thorough and easily understood introduction, the editors review the principles of cancer screening in a manner that even the statistically challenged should be able to comprehend. Seven chapters discuss screening for each of the major tumor types, and an eighth examines screening for a variety of less common malignancies. For each type of cancer, the literature
BRAIN-DERIVED NEUROTROPHIC FACTOR AS A MARKER FOR IMMEDIATE ASSESSMENT OF THE SUCCESS OF RENAL SYMPATHETIC DENERVATION
Authors: Oliver Doerr, Christoph Liebetrau, Helge Mollmann, Luise Gaede, Christian Troidl, Vanessa Haidner, Jens Wiebe, Sandra Voss, Timm Bauer, Christian Hamm, Holger Nef
Journal: Journal of the American College of Cardiology (2015)
Mir-21 Mediates Hematopoietic Suppression in MDS by Activating TGF-b Signaling,
Authors: Tushar D. Bhagat, Li Zhou, Lubomir Sokol, Ioannis Mantzaris, Krishna Gundabolu, Shanisha A. K. Gordon, Yiting Yu, Sangeeta Nischal, Rahul Polineni, Carolina Schinke, Grigorios Chrysofakis, Amittha Wickrema, Andrea Pellagatti, Jacqueline Boultwood, Ulrich G Steidl, Gang Liu, Alan F List, Markus Bitzer, Amit Verma
Journal: Blood (2011)
On the occasion of Meinhard Classen's 70th birthday
Journal: Endoscopy (2006)

This issue is dedicated to my predecessor and mentor Meinhard Classen - to follow him as Editor, and to be his pupil in many other aspects of medicine, gastroenterology and endoscopy, has always been a great honor and pleasure. My colleagues on the editorial team and I wish him all the best for his 70th birthday and are trying very hard to continue his tradition in the journal - our aim is to make him proud every time he has an issue in his hands and can see how his successors are continuing what he developed.
Coloscopie standard vs. coloscopie assistée par Endocuff dans le cadre du programme de dépistage du cancer colorectal en Grande Bretagne (Etude E-cap): une étude randomisée
Journal: Endoscopy (2017)

Un des principaux champs de développement technologique en endoscopie digestive a été l’amélioration de la détection des polypes coliques lors d’une coloscopie de dépistage du cancer colorectal (CCR) ou dans le cadre d’une surveillance endoscopique. Les polypes manqués par la coloscopie sont en partie responsables des cancers d’intervalle, définis par le diagnostic d’un CCR survenant entre deux examens programmés de surveillance ou dans un certain délai après une coloscopie index considérée comme normale.
The Retrospect of Medicine:
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Counterclockwise
Authors: M. C. Meehan
Journal: JAMA (1970)

Since the publication of Clifford Beers'<i>A Mind That Found Itself</i>, many books have been written describing the experience of mental illness. Some of these have been frankly autobiographical, some in the form of fiction. One of the best and most successful of the latter was<i>The Snake Pit</i>by Mary Jane Ward. This was a novel about a young married woman who became psychotic, was hospitalized in a state hospital, and eventually recovered. After this book was published, the author became very active in the mental health movement, traveling, visiting hospitals, lecturing, and working in many ways to improve the conditions in hospitals. Now Mary Jane Ward has written a sequel, called<i>Counterclockwise</i>, in which the heroine, after a period of exhausting activity, suffered a relapse or recurrence. This time she was treated on a fine psychiatric service, part of a general hospital. There she received intensive psychotherapy, excellent
Patient Care after Percutaneous Coronary Artery Interventions
Authors: Chike Magnus Nzerue
Journal: Annals of Internal Medicine (1998)

Letters1 April 1998Patient Care after Percutaneous Coronary Artery InterventionsChike Magnus Nzerue, MDChike Magnus Nzerue, MDMorehouse School of Medicine; Atlanta, GA 30310Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although O'Meara and Dehmer's discussion of contrast-induced nephropathy was illuminating [1], the authors did not mention another renal complication of these interventions-cholesterol atheroembolic renal disease. This is concerning because the disease is the major consideration in the differential diagnosis of contrast nephropathy and diagnosis of atheroembolic renal disease relies on a high index of suspicion.Cholesterol atheroembolic renal disease results when cholesterol crystals separate from atheromatous plaques; lodge in small renal arteries; and cause ischemia, renal failure, and perivascular inflammation. Embolization results from mechanical disruption of atheromatous plaque during angiographic procedure or, rarely, results spontaneously [2]. It ...References1. O'Meara JJ, Dehmer GJ. Care of the patient and management of complications after percutaneous coronary artery interventions. Ann Intern Med. 1997; 127:458-71. Google Scholar2. Colt HG, Begg RJ, Saporito JJ, Cooper WM, Shapiro AP. Cholesterol emboli after cardiac catheterization. Eight cases and review of the literature. Medicine (Baltimore). 1988; 67:389-400. Google Scholar3. Fine MJ, Kapoor W, Falanga V. Cholesterol crystal embolization. A review of 221 cases in the English literature. Angiology. 1987; 38:769-84. Google Scholar4. Tunick PA, Perez JL, Kronzon I. Protruding atheromas in the thoracic aorta and systemic embolization. Ann Intern Med. 1991; 115:423-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Chike Magnus Nzerue, MDAffiliations: Morehouse School of Medicine; Atlanta, GA 30310 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 599KeywordsAtheromasCholesterolCoronary arteriesEosinophiliaInflammationPatientsRenal arteriesRenal diseasesRenal failureRenal ischemia ePublished: 15 August 2000 Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
NHS review
Authors: R. Gabriel
Journal: BMJ (1989)

SIR,-Mr M I Alloub and colleagues reported an increased incidence of cervical intraepithelial neo- plasia in women with renal allografts.' Immuno- suppression has been proposed as a high risk factor in the development of cervical dysplasia.2This suggestion prompted us to investigate the cervices of 27 women who attended the sexually trans- mitted diseases clinic at St Mary's Hospital and were found to be infected by HIV.Examination included cytology, colposcopy, and histology when indicated.Ten of the 27 women had an abnormal smear, 14 an abnormal colposcopic cervical appearance, and 12 of the 14 who underwent biopsy a histological abnormality (table).Cytological findings did not always correlate with the histological outcome.Results of cervical investigation of 27 women with HIV' tnfection No of patients Cytology: Normal
A positive strategy for the nation's health
Authors: L. Breslow
Journal: JAMA (1979)

IT IS TIME to establish a positive strategy for the nation's health. Fortunately, the last few years have brought a new momentum toward improved health, making it easier to prepare a forward thrust. For example, the total age-adjusted death rate in the nation has been dropping about 1.0% to 1.5% annually from 1920 until the 1950s. Then the decline slowed to less than one third the previous rate. Since 1970, the total age-adjusted death rate has been dropping faster again, 2.0% annually.<sup>1</sup>Infant mortality practically leveled out from 1955 to 1965, but in recent years it has turned steeply downward, about 4% per year (for most of the data in this paper I am indebted to the National Center for Health Statistics, Hyattsville, Md; responsibility for interpretation is mine). While the expectation of life at birth increased quite steadily from 1920 to 1955, the decade 1955 to 1965 showed