tbuckley/cabot-search huggingface dataset:
THE SALT OF THE EARTH.
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Complete vessel revascularization vs. Ischemic vessel revascularization in patients with multivessel disease; 5 year follow-up in the multivessel PTCA multicenter randomized trial (MRT) Katsuya Kitano, Tohru Kobayashi, Hideo Tamai, Takahiko Suzuki, Hideo Nishikawa, Osamu Katoh, MRT investigators. Kyoto Katsura Hospital Cardiovascular Center, Kyoto, Japan
Journal: Journal of the American College of Cardiology (2001)
General Medicine
Authors: Donald M. Clark
Journal: New England Journal of Medicine (1954)

THERE are thousands of general physicians and millions of their patients who are more than happy with their mutual relations and ask for no other. Nevertheless, this field is one of the most controversial in medicine, and a volume would be required to present all phases of the many issues involved.Even the name of the field and the title of its practitioners has been subjected to much discussion. "General practitioner," "family physician," "general physician," "local medical doctor," "personal physician" and "generalist" constitute a sample list attacked and defended by all branches of the profession. I have arbitrarily chosen the . . .
And then there were none. The demise of national medical television
Authors: G. D. Lundberg
Journal: JAMA (1995)

In the summer of 1993, three national medical television networks existed: Lifetime Medical Television, Medical News Network, and American Medical Television. In August 1993, Lifetime Medical Television ceased operations after nearly 10 years of significant educational service. And then there were two. In August 1994, Medical News Network was cancelled, after having never really gotten off the ground except in elaborate program development and national market testing. And then there was one. In December 1994, after 5 years of successful programming for physicians, other health professionals, and patients, first on the Discovery Channel, and then on CNBC, the owners of American Medical Television (NBC Cable, the American Medical Association, the Orbis Broadcast Group, and Dr Art Ulene) voted to dissolve the partnership, ceasing operations before February 1995.<sup>1</sup>And then there were none. As with any complex venture, the reasons for these failures were complex. But the common reason was
A Combined Papillary Mesothelioma and Adenomatoid Tumor of the Omentum
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1190 HEPATITIS C IN THE GENERAL POPULATION OF VARIOUS ETHNIC ORIGINS LIVING IN THE NETHERLANDS: SHOULD NON-WESTERN MIGRANTS BE SCREENED?
Authors: A.T. Urbanus, T.J.W. van de Laar, A. van den Hoek, F.R. Zuure, A.G.C.L. Speksnijder, G.G. Baaten, T. Heijman, H.J. Vriend, E.L.M. Op de Coul, R.A. Coutinho, M. Prins
Journal: Journal of Hepatology (2011)
In Reply
Authors: Ronald R. de Krijger, Christian M. Zwaan
Journal: Journal of Clinical Oncology (2007)

Rather than subjecting a 10-year-old boy with advanced differentiated thyroid carcinoma to bronchoalveolar lavage for exclusion of miliary tuberculosis, we would have endeavored to extirpate the papillary thyroid carcinoma en bloc from the thyroid bed at the initial operation in an effort to preclude eventual tracheal, esophageal, and recurrent laryngeal nerve invasion 3 and to maximize the effectiveness of radioiodine therapy.In experienced hands, complete resection of a papillary thyroid carcinoma extending into the juxtathyroidal tissue is often feasible at the initial operation, resulting in sustained local control in the neck.Conversely, the long-term effectiveness of radioiodine therapy on gross residual disease in the thyroid bed of patients with differentiated thyroid carcinoma remains unclear.
Phenylbutazone
Authors: B. Edgar
Journal: BMJ (1953)

<h3>Abstract</h3> <h3>Objective</h3> To characterise and analyse the experiences of trial researchers of if and how conflicts of interest had unduly influenced clinical trials they had worked on, what management strategies they had used to minimise any potential influence, and their experiences and views on conflicts of interest more generally. <h3>Design</h3> Qualitative interview study. <h3>Participants</h3> Trial researchers who had participated in at least 10 clinical trials with methodological or statistical expertise. Researchers differed by geographical location, educational background, and experience with different types of funders. Interviewees were identified by searches on Web of Science and snowball sampling. 52 trial researchers were approached by email; 20 agreed to be interviewed. <h3>Setting</h3> Interviews conducted by telephone, recorded, transcribed verbatim, imported to NVivo 12, and analysed by systematic text condensation. Semistructured interviews focused on financial and non-financial conflicts of interest. <h3>Results</h3> The interviewees had participated in a median of 37.5 trials and were mainly male physicians who had experience with commercial and non-commercial trial funders. Two predefined themes (influence of conflicts of interest and management strategies) and two additional themes (definition and reporting of conflicts of interest) emerged. Examples of perceived influence of conflicts of interest were: choice of inferior comparator, manipulation of the randomisation process, prematurely stopping the trials, fabrication of data, blocking access to data, and spin (eg, overly favourable interpretation of the results). Examples of strategies to manage conflicts of interest were: disclosure procedures, exclusion of the funder from design and analysis, independent committees, contracts ensuring complete access to the data, and no restriction by the funder on analysis and reporting. Interviewees used different definitions or thresholds for what they considered to be conflicts of interest, and they described different criteria for when to report them. Some interviewees considered non-commercial financial conflicts of interest (eg, funding of trials by governmental health agencies with a political agenda) to be equally or more important than commercial financial conflicts of interest (eg, funding by drug and device companies), but more challenging to report and manage. <h3>Conclusion</h3> This study described how trial researchers perceive conflicts of interest unduly influencing clinical trials they had worked on, and the management strategies they used to prevent these influences. The results indicated considerable variability in researchers’ understanding of what conflicts of interest are and when they should be reported.
Virus antibody titers in multiple sclerosis patients, siblings, and controls
Authors: J. A. Brody
Journal: JAMA (1971)

Virus antibody titers of multiple sclerosis (MS) patients were higher than titers of carefully matched controls for measles, type C influenza, herpes simplex, parainfluenza 3, mumps, and varicella-zoster, and not consistently higher than titers of controls for adenovirus, parainfluenza 2 and 3, and types A and B influenza. Virus antibody titers among MS patients were not higher for any of these agents than were titers of their siblings of the same sex born within three years of the patient, suggesting a familial effect on these responses. The study population consisted of 97 MS patients selected by two neurologists from among 500 patients screened, 47 siblings, and 64 controls. The observed pattern can be interpreted as indicating that viruses and immune responses play a role in the etiology of MS, but that we are probably dealing tangentially with the problem.
Arthritis and Rheumatism, New York
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the Health Care Financing Administration
Authors: G. R. Wilensky
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Irreversible Binding and Adrenocorticolytic Activity of the DDT Metabolite 3-Methylsulfonyl-DDE Examined in Tissue-Slice Culture
Authors: Örjan Lindhe, Bert-Ove Lund, Åke Bergman, Ingvar Brandt
Journal: Environmental Health Perspectives (2001)

The persistent adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE (MeSO(2)-DDE) was originally identified in Baltic grey seals, a population suffering from adrenocortical hyperplasia. In mice, MeSO(2)-DDE induces mitochondrial degeneration and cellular necrosis in the adrenal zona fasciculata. In this study, we used precision-cut tissue slice culture to examine local CYP11B1-catalyzed irreversible binding of MeSO(2)-DDE in the murine adrenal cortex. We also examined effects on steroid hormone secretion, histology, and ultrastructure. As determined by microautoradiography, selective binding occurred in zona fasciculata of slices exposed to MeSO(2)-[(14)C]-DDE. Quantification of binding by phosphorautoradiography revealed a 3-fold reduction of binding in slices co-exposed to the CYP11B1 inhibitor metyrapone. As measured by HPLC, corticosterone and 11-deoxycorticosterone secretion to the medium increased linearly for at least 24 hr. Addition of the ACTH analog tetracosactide caused an 8-fold increase in corticosterone secretion. Addition of metyrapone reduced corticosterone secretion 4-fold. Exposure of slices to MeSO(2)-DDE (50 microM) reduced the rate of corticosterone secretion by 90% after 24 hr of incubation. As determined by electron microscopy, vacuolated mitochondria were present in zona fasciculata of slices exposed to MeSO(2)-DDE (50 microM) for 24 hr. Our findings show that all effects of MeSO(2)-DDE previously reported in vivo could be reproduced in adrenal slice culture ex vivo. This test system allows analysis of zone-specific irreversible binding and effects on steroid hormone secretion and target cell ultrastructure. We propose adrenal slice culture as a simple ex vivo test system with which to examine the adrenocorticolytic activity of xenobiotics in human and wild animal tissue.
Abstract 3605: Lipoprotein-Associated Phospholipase A <sub>2</sub> and Myocardial Infarction in Women
Authors: Ida J Hatoum, Jeanenne J Nelson, Kathryn Rexrode, JoAnn Manson, Eric B Rimm
Journal: Circulation (2007)

Lipoprotein-Associated Phospholipase A 2 (Lp-PLA 2 ) is an enzyme that hydrolyzes oxidized phospholipids in low-density lipoprotein, creating pro-inflammatory molecules that are hypothesized to play a role in the development of coronary heart disease. Many of the previous studies that have shown Lp-PLA 2 activity to be associated with a moderate increase in risk for CHD have been conducted mostly among men. The one previous study among women was small and reported a modest nonsignificant increase in risk. Thus, the association of Lp-PLA 2 with CHD risk in women warrants exploration. We conducted a nested case-control study among participants in the Nurses’ Health Study who provided a blood sample in 1989 –1990. With approximately 15 years of follow-up through 2004 we identified 438 incident cases of fatal and non-fatal MI and used incidence density sampling to match controls to cases (2:1) based on age, smoking status, date of blood draw, and fasting status at the time of blood draw. Lp-PLA 2 activity was measured using a colorimetric activity assay. We used conditional logistic regression in multivariate models. Compared to women in the lowest tertile, the relative risk of CHD for women in the second and third tertiles of Lp-PLA 2 activity were 1.75 (95% CI 1.26 –2.44) and 2.67 (1.94 – 3.69), respectively (p for trend = 0.002). After further adjustment for LDL cholesterol, c-reactive protein,body mass index, alcohol intake, aspirin use, physical activity, and post-menopausal hormone use, and histories of hypercholesterolemia, diabetes, and hypertension, the relative risks were similar: 1.81 (1.26 – 2.60) comparing the second to the first tertile, and 2.26 (1.54 – 3.30) comparing the third to the first tertile (p trend &lt; 0.001). Further adjustment for HDL cholesterol modestly attenuated the relative risks to 1.62 (1.13 – 2.35) and 1.81 (1.20 – 2.71) (p trend = 0.007). The significantly elevated relative risks were not appreciably modified by HDL or LDL. In conclusion, we found that Lp-PLA 2 activity was associated with increased risk for MI among women. Adjustment for standard risk factors modestly attenuated this relationship, but Lp-PLA 2 remained a strong independent predictor of MI in this population of women healthy at baseline.
Anesthesiology
Authors: E. M. Papper, S. H. Ngai
Journal: New England Journal of Medicine (1954)

Dimethyl d-Tubocurarine Dimethyl d-tubocurarine was synthesized by Collier et al.71 in 1948 and introduced to clinical anesthesia in 1949.72 Its action is similar to that of d-tubocurarine. Unna and his co-workers73 , 74 compared its action with that of d-tubocurarine in man. Its duration of action is slightly shorter than that of d-tubocurarine. Its potency, as measured by depression of grip strength, is higher than that of d-tubocurarine (equipotent dose in micrograms of ions per kilogram was 107 for d-tubocurarine and 41 for dimethyl d-tubocurarine). According to their studies dimethyl d-tubocurarine has a higher coefficient of safety regarding the respiratory sparing effect . . .
THE FALLACY OF THE "PRIMITIVE"
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gaseous monoxides: a new class of micro vascular regulator in the liver
Authors: M. Suematsu, Y. Wakabayashi, Y. Ishimura
Journal: Cardiovascular Research (1996)

Gaseous monoxides such as nitric oxide (NO) and carbon monoxide (CO) have recently attracted great interest as a regulator of cell and organ functions. When exposed to endotoxin, cytokines or ischemia-reperfusion, the liver produces larger amounts of NO than those in the control via the activity of inducible NO synthase which can alter a variety of organ functions such as sensitivity of vascular tone to catecholamine, mitochondrial membrane potential, biliary transport and tissue regeneration. On the other hand, the liver constitutively produces CO through the reaction of heme oxygenase. CO generated in the liver tissue can reach sinusoidal vessels and relax fat-storing Ito cells—the liver-specific microvascular pericytes covering the sinusoidal wall—and thereby serves as an endogenous modulator of vascular tone. Two isoforms of the CO-generating enzyme have been characterized: heme oxygenase-1 which is inducible by a variety of stressors, and heme oxygenase-2 which constitutes the major enzyme activity under physiological conditions in the liver. Although it is still unknown whether excessive CO generation by the inducible heme oxygenase activity may preserve or jeopardize the integrity of microvascular function in the liver, the potential importance of this double-edged molecule has just emerged much like nitric oxide, another gaseous molecule that was established as a neurovascular mediator inducing vascular cell relaxation. This article provides an overview of the pathophysiological roles of these gaseous monoxides in regulation of microvascular function in the liver.
Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer (NSCLC): COVeRT study.
Authors: Anna Rachelle Austria Mislang, Kenneth B. Pittman, Christos Stelios Karapetis, Sonya Stephens, Martin Borg, Nimit Singhal
Journal: Journal of Clinical Oncology (2014)

e18525 Background: This South Australian single arm, muti-centre Phase III trial evaluated the progression free survival of combination oral vinorelbine and cisplatin given concurrently with radiotherapy for Stage III non small cell lung cancer (NSCLC). Methods: Patients received 2 cycles of oral vinorelbine 50 mg/m2 day 1(D1), day 8 (D8) and intravenous cisplatin 50mg/m2D1 and D8 in a 21 day cycle each. Chemotherapy was given concurrently with radiotherapy 60 Grays (Gy) in 30 fractions at 2 Gy/ fraction to the isocentre, treating all fields daily, 5 days a week over 6 weeks using 10 MV photons and 3-D CRT. Primary endpoint was to evaluate the progression free survival of combination oral vinorelbine and cisplatin given concurrently with radiotherapy in Stage III NSCLC. The secondary end point assessed the response rates, over-all survival and safety profile. Results: Fourty-four eligible patients with Stage III non small cell lung cancers comprising mainly of squamous cell- and adeno-carcinomas were enrolled in the trial. One was withdrawn as unable to give desired radiotherapy dose and four patients did not complete the treatment and were excluded from analysis. None achieved complete response. The confirmed radiological response assessment was available for 39 patients with 11 (28%) patients had partial response (PR), 28(72%) had stable disease (SD), none had progressive disease (PD) or complete response (CR) giving a total response rate of 28%.Disease Control Rate (DCR) was 83%. PFS and OS are still pending (available by 1 March 2014). Conclusions: Two cycles of chemotherapy with oral vinorelbine and cisplatin given concurrently with radical radiation appeared to be well tolerated with favourable toxicity profile and significant activity in stage III NSCLC. The oral route may reduce planning constraints linked to CT-RT combination. Initial toxicity data were encouraging and this combination may therefore qualify as a future reference treatment for unresectable IIIA/IIIB NSCLC. Clinical trial information: ACTRN12609000003279.
Editorial: Idiopathic oedema of women.
Journal: BMJ (1976)

pulmonary maturity is attained, and more depends on this than anything else.So it is the time of delivery that matters, because that is what determines lung functional development -a view borne out by Gabert et al,6 who showed that caesarean section was not associated with respiratory distress when the lecithin-sphingomyelin ratio offered a good prognosis.Although Usher et al7 thought that caesarean section was associated with the distress syndrome, they too found it to be virtually eliminated if the length of gestation was 37-38 weeks.Similarly the second perinatal mortality survey' found that probably the respiratory distress syndrome could not be firmly associated with caesarean section but was mainly associated with pre-eclampsia,' placenta praevia, other ante- partum haemorrhages, and some elective sections.In all these cases "iatrogenic immaturity could be a factor."