tbuckley/cabot-search huggingface dataset:
AURELIA: A randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC).
Authors: Eric Pujade-Lauraine, Felix Hilpert, Béatrice Weber, Alexander Reuss, Andres Poveda, Gunnar Kristensen, Roberto Sorio, Ignace B. Vergote, Petronella Witteveen, Aristotelis Bamias, Deolinda Pereira, Pauline Wimberger, Ana Oaknin, Mansoor Raza Mirza, Philippe Follana, David T. Bollag, Isabelle Ray-Coquard
Journal: Journal of Clinical Oncology (2012)

LBA5002^ Background: In three phase III trials in OC (2 front line, 1 PT-sensitive recurrent), BEV + CT → BEV significantly improved progression-free survival (PFS) vs CT alone. AURELIA is the first randomized trial of BEV in PT-resistant OC. Methods: Eligible patients (pts) had OC (measurable by RECIST 1.0 or assessable) that had progressed ≤6 mo after ≥4 cycles of PT-based therapy. Pts with refractory OC, history of bowel obstruction, or &gt;2 prior anticancer regimens were ineligible. After CT selection by the investigator (pegylated liposomal doxorubicin [PLD], topotecan [TOP], or weekly paclitaxel [PAC]), pts were randomized to CT either alone or with BEV (10 mg/kg q2w or 15 mg/kg q3w depending on CT) until progression (PD), unacceptable toxicity, or withdrawal of consent. Pts in the CT-alone arm could cross over to BEV monotherapy at PD. The primary endpoint was PFS by RECIST. Secondary endpoints included objective response rate (ORR), overall survival, safety, and quality of life. The design provided 80% power to detect a PFS hazard ratio (HR) of 0.7 with 2-sided log-rank test and α=0.05 after 247 events, assuming median PFS of 4.0 mo with CT and 5.7 mo with CT + BEV. Results: Between Oct 2009 and Apr 2011, 361 pts were randomized to receive selected CT (PLD: 126; PAC: 115; TOP: 120) alone or with BEV. Median follow-up after 301 PFS events was 13.5 mo. Conclusions: In PT-resistant OC, BEV + CT provides statistically significant and clinically meaningful improvement in PFS and ORR vs CT alone. Strict inclusion criteria minimized the incidence of BEV AEs. This is the first phase III trial in PT-resistant OC to show benefit with a targeted therapy and improved outcome with a combination vs monotherapy. [Table: see text]
Anxiety and depression effects during drug provocation test
Authors: Laura M. Losappio, Alessandra Cappai, Alessandra Arcolaci, Iuliana Badiu, Patrizia Bonadonna, Elisa Boni, Claudia Bussolino, Marco Caminati, Pietro Galati, Enrico Heffler, Rossella Intravaia, Marina Mauro, Ilaria Massaro, Antonino Gaetano Romano, Gabriele Rumi, Anna Parolo, Stefano Pizzimenti, Elide Anna Pastorello
Journal: Journal of Allergy and Clinical Immunology (2018)
PHILADELPHIA LETTER.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thyroid failure and protirelin (thyrotropin-releasing hormone) test abnormalities in depressed outpatients
Authors: H. A. Sternbach
Journal: JAMA (1983)

Forty-four consecutive outpatients referred to a psychiatric hospital for evaluation of depression and anergia were assessed by means of the protirelin (thyrotropin-releasing hormone) test. Nineteen patients (43%) had a blunted thyrotropin (TSH) response to protirelin, while six patients (13.5%) had augmented TSH responses indicating some degree of hypothyroidism. One patient had a low thyroxine level, while three patients had elevated basal TSH levels. Five of the six patients with augmented TSH responses were found to have antithyroid antibodies. These results suggest that a majority of depressed outpatients have abnormalities on the protirelin test and that the TSH response to protirelin is useful in both confirming a diagnosis of major depression and assessing thyroid status. (<i>JAMA</i>1983;249:1618-1620)
ERNST SALKOWSKI, 1844-1923
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicine and religion. An overview
Authors: T. J. O'Donnell
Journal: JAMA (1970)

The respective professions, medicine and religion, are so distinct from one another that in the past they have been sometimes mutually incommunicative. This has warranted an American Medical Association department designed specifically to promote mutual understanding. And yet both professions are deeply concerned with the welfare of the sick, and thus meet in the object of our solicitudes. Moreover, we share certain characteristics in common—certain professional mantles, if you will. And how we bear them very much affects ourselves, and consequently our relationships with each other, and hence our relationships with the patient. To enumerate some of these common characteristics, let me point out that together we share a position of privilege in society and a hierarchy of service. Each of the professions has a moral code and a dogmatic turn of mind. Each of us, with our colleagues, has a responsibility for protecting and enriching the lives of others.
Landois' Lehrbuch der Physiologie des Menschen mit besonderer Berücksichtigung der praktischen Medizin.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency health services in areas of low population density
Authors: J. A. Waller
Journal: JAMA (1969)

Emergency health services in the prehospital phase must be emphasized to save, among persons who die in less than 24 hours, the substantial minority who are dead or moribund when they reach the emergency room. Among adults, a greater percentage of inherently and potentially serious emergencies than minor emergencies occur at night, are in rural areas, and involve persons who have been drinking and often are problem drinkers. Planning for emergency services must be based on separate evaluation of minor and serious emergencies and on consideration of the separate problems and resources of urban and rural areas, the latter including areas of low population density in predominately urban communities. Overemphasis upon services for persons injured on the highway at the expense of services for the entire range of injury and illness must be avoided.
Advantages
Authors: Fred Charatan
Journal: BMJ (2004)

tice meetings.She told of her experience in another practice where there was a lot of formal communication but to little effect: It was dreadful.That is one of the reasons I left.We had weekly practice meetings which tended to go on for hours which did not achieve anything and then other meetings were called in the week.We seemed to have more meetings than surgeries towards the end.(Practice 8, general practitioner A)
Errata: Toxicity and residue studies in dairy animals with FireMaster FF-1 (polybrominated biphenyls
Journal: Environmental Health Perspectives (1978)

zation buffer (25 mM KPO4, pH 7.3 containing 5 mM NaEDTA and 10 mM dithiothreitol and were" Paragraph 4, lines 6-7 to read: "Whole liver (ca.0.5-0.7 mg MIC protein) were diluted to 1.0 ml with 0.1M KPO4, pH 7, and bubbled for 2"
HYDROGEN PEROXIDE IN DIPHTHERIA.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NCI Monograph No. 5
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article NCI Monograph No. 5 Get access JNCI: Journal of the National Cancer Institute, Volume 26, Issue 5, May 1961, Page 1293, https://doi.org/10.1093/jnci/26.5.1293-a Published: 01 May 1961
Treated Water in Pools, Parks Hides Disease-Causing<i>Cryptosporidium</i>
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Invisibly Disabled
Authors: Jacob Adashek
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
HERPES GESTATIONIS
Authors: BENJAMIN JONES
Journal: British Journal of Dermatology (1901)

Journal Article HERPES GESTATIONIS Get access BENJAMIN JONES, L.R.C.P. BENJAMIN JONES, L.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 13, Issue 8, 1 August 1901, Pages 308–309, https://doi.org/10.1111/j.1365-2133.1901.tb16398.x Published: 01 August 1901
Colitis of long duration
Authors: E. H. Eliscu
Journal: JAMA (1968)

Dr. Edward H. Eliscu: The patient is a 50-year-old white woman who for 30 years had experienced malaise, fever, vomiting, and non-bloody diarrhea which was recently associated with weakness. The past medical history and the family history were noncontributory. Physical examination revealed a pale woman in no distress. Abdominal examination showed nothing remarkable. Laboratory studies revealed a hemoglobin level of 10 gm/100 cc, white blood cell count of 22,000, and a temperature of 101 F (38.3 C). Results of the guaiac test on the stool on several occasions gave 2+ values and on several occasions were not positive. Sigmoidoscopy was performed and the findings were said to be characteristic of ulcerative colitis. The stool examination revealed a few pus cells and culture produced<i>Escherichia coli</i>. The patient was treated with intravenous fluid and improved. Since her first episode in 1937, she had regulated her diet, eliminating roughage and spicy foods,
Lessons learned from a patient. Changing concepts rather than facts
Authors: D. Beccia
Journal: JAMA (1976)

Many concepts pertaining to urinary tract infections and considered to be established or dogma are, in fact, incorrect or subject to modification. The physician should not be too rigid in his thinking regarding this disorder, as new knowledge constantly becomes available, disproving previously cherished beliefs. The case described appears to underscore this better than any hypothetical situation. (<i>JAMA</i>236:1268-1269, 1976)
A plea for the condom, especially for teenagers
Authors: Y. M. Felman
Journal: JAMA (1979)

DURING the past two decades, a revolution has taken place in contraceptive use in this country. The diaphragm and the condom, mainstays of contraception until the advent of the pill, have gradually fallen into disfavor among increasingly wide segments of the population who prefer the more modern and convenient oral contraceptive or the intrauterine devices (IUDs). Although condom sales have actually risen in the past ten years, its use among teenagers has declined.<sup>1</sup>The net effect of these developments has been to increase dramatically the number of persons using some form of effective contraception. Nevertheless, in calendar year 1976 there were 588,744 pregnancies in teenagers between the ages of 15 and 19 years that were carried to term in the United States,<sup>2</sup>an all-time high; 231,734 legal abortions were performed in this same age group.<sup>3</sup>Furthermore, despite easy and, until recently, free-of-cost access to abortion since the
Cardiovascular Complications of Outpatient Cardiac Rehabilitation Programs
Authors: Steven P. Van Camp
Journal: JAMA (1986)

To determine the incidence of major cardiovascular complications in outpatient cardiac rehabilitation programs, we obtained data from 167 randomly selected cardiac rehabilitation programs via mailed questionnaires and follow-up telephone calls. These 167 programs reported that 51 303 patients exercised 2 351 916 hours from January 1980 through December 1984. Twenty-one cardiac arrests (18 in which the patient was successfully resuscitated and three fatal) and eight nonfatal myocardial infarctions were reported. The incidence rates per million patient hours of exercise were 8.9 for cardiac arrests (one per 111 996 patient-hours), 3.4 for myocardial infarctions (one per 293 990 patient-hours), and 1.3 for fatalities (one per 783 972 patient-hours). There was no statistically significant difference in frequency of these events among programs of varying size or extent of electrocardiographic monitoring. These data indicate that current cardiac rehabilitation practice allows for prescribed supervised exercise by patients with cardiovascular disease to be performed at a low risk of major cardiovascular complications. (<i>JAMA</i>1986;256:1160-1163)
Patient–Doctor
Authors: M A Khan
Journal: Annals of Internal Medicine (2000)

On Being a Patient1 August 2000Patient–DoctorMuhammad Asim Khan, MD, FRCPMuhammad Asim Khan, MD, FRCPCase Western Reserve University School of Medicine; Cleveland, OH 44109Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-3-200008010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail On a recent visit to New York City, as I was taking a 15-block walk in midtown Manhattan, I was thinking about how fortunate I have been. In 1998 I underwent a transluminal coronary angioplasty with stent placement and subsequently I received anticoagulant therapy, which resulted in painless hematuria. This led to the discovery of renal-cell carcinoma, for which I had a radical nephrectomy. This experience has prompted me to share with you my perspective as a patient for 44 years, now facing the added uncertainty that a cancer patient has to live with.You see, I have had arthritis ... Author, Article, and Disclosure InformationAffiliations: Case Western Reserve University School of Medicine; Cleveland, OH 44109Corresponding Author: Muhammad Asim Khan, MD, Case Western Reserve University School of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAccomplishments of Heinz Baumberger PhD: a remarkable patient with ankylosing spondylitis for 72 yearsCelebrating the ACP Centennial: From the Annals Archive—Ankylosing SpondylitisDeborah Cotton, MD, MPHLife on the Receiving End: A Qualitative Analysis of Health Providers??? Illness NarrativesSuffering, Science and Sabotage 1 August 2000Volume 133, Issue 3Page: 233-235KeywordsAngioplastyAnkylosing spondylitisArthritisCoronary angioplastyHipStent implantationSurgeonsThoraxTotal hip arthroplastyTotal hip replacement ePublished: 15 August 2000 Issue Published: 1 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Allergic reactions to drugs and biologic agents
Authors: R. Patterson
Journal: JAMA (1982)

ADVERSE reactions to drugs are common clinical problems and a significant source of morbidity and mortality. The true prevalence is difficult to determine, but estimates of drugrelated complications have ranged from 6% to 15% of hospitalized patients. A variety of mechanisms, presumably unrelated to hypersensitivity, account for the majority of these reactions (Table 6-1). Actual allergic or immunologic drug reactions likely account for 25% or less of the overall number of adverse drug reactions (Table 6-2). A minority of adverse drug reactions, perhaps 6% to 10%, are secondary to or closely associated with immunologic mechanisms (Table 6-2). The classification (as listed in Tables6-1 and 6-2) is arbitrary. Many of the mediators of hypersensitivity are involved in the host's response to toxic injury. It is often difficult to tell if a condition represents a primary hypersensitivity reaction or a response to another form of organ damage. An understanding of the
"Early Curable Stage" of Rheumatoid Arthritis
Authors: J. W. Todd
Journal: BMJ (1965)

should be made of each necessary diagnostic procedure.A full description of our experience with monoarticular arthritis in children has recently been published, which a more specialized audience may perhaps find useful.'Finally, as Professor Illingworth well knows, some large-scale well-controlled studies have shown that cortisone,2 prednisone either in moderate dosage,3 or in larger dosage,4 or in more prolonged dosage,5 shows no superiority to acetylsalicylic acid in prevent- ing residual rheumatic heart disease.Others have claimed that it does, and there are con- trolled trials to support this view.Our own view at Taplow on the basis of various con- trolled trials and with experience of over 1,500 cases of rheumatic fever is as expressed in my article, that prednisone does not pre- vent the development of rheumatic heart disease but may be better than salicylate in preventing failure in cases of moderate or severe carditis.-Iam, etc.,
From the authors:
Authors: G. Sotgiu, R. Centis, C. Lange, L. D'Ambrosio, G. Guenther, A. Spanevello, G. B. Migliori
Journal: European Respiratory Journal (2010)

to use it with caution, in a dose never exceeding 600 mg, once a day, in patients with MDR-and XDR-TB, who have few other drug options.All of our patients were given written instruction on the side-effects that they are likely to encounter and, at each follow-up, these were diligently checked for.In all patients treated with linezolid, clinical, haematological and neurological evaluations are mandatory on a monthly basis, as well as frequent opthalmological tests.To conclude, the high frequency of adverse effects to linezolid warrants extreme caution when this drug is used for prolonged periods of time in MDR-TB patients.Thus, prospective, randomised and multicentre evaluations are needed in order to test the efficacy of linezolid as well as the short-and long-term tolerability of the drug in TB patients.