tbuckley/cabot-search huggingface dataset:
WHO considers regulating ads, sale of medical products on Internet
Authors: A. A. Skolnick
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of Urocanic Acid in the Urine in Status Asthmaticus
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The breast cancer controversy. A natural experiment
Authors: M. M. Black
Journal: JAMA (1977)

The number and types of breast lesions treated surgically at the Flower and Fifth Avenue Hospitals during the period from November 1974 through February 1976, increased sharply in monthly incidence as compared with the period from January 1973 through October 1974. This increase was attributable to public awareness of breast cancer because of the publicity given to its occurrence in the wives of the President and Vice-President. However, the consequent increase in mammography and breast surgery was not accompanied by any improvement in the stage characteristics of the breast cancers treated. The proportion of prognostically unfavorable stage II cases with involvement of four or more axillary nodes was undiminished, while the proportion of stage 0 and stage I cases was not increased among breast cancers diagnosed since Nov 1, 1974. (<i>JAMA</i>237:970-971, 1977)
Snoring and excessive daytime somnolence among Polish middle-aged adults
Authors: J Zielinski, A Zgierska, M Polakowska, L Finn, P Kurjata, W Kupsc, T Young
Journal: European Respiratory Journal (1999)

There is considerable interest in the association of snoring and health consequences that have been linked to more severe sleep-disordered breathing, including obstructive sleep apnoea syndrome. The goal of this investigation was to assess the independent association of heavy, habitual snoring and daytime sleepiness. For this, a cross-sectional, population based study of snoring, sleepiness and other factors was conducted using the Warsaw sample of the Multinational Monitoring of Trends and Determinants of Cardiovascular Diseases (MONICA) study, a population-based multicentre study of cardiovascular disease. The well-defined MONICA sample of middle-aged males and females also allowed estimation of age- and sex-specific prevalences of habitual snoring in Polish adults. Data on self-reported snoring frequency and loudness, and daytime sleepiness using the Epworth Sleepiness Scale (ESS) and other questions, were collected with a postal questionnaire. Seventy-nine per cent of the MONICA sample completed the questionnaire, yielding a total of 1,186 participants. Of the total sample, 27% of the females and 48% of the males reported habitual snoring ("often" or "always"). There was an independent association of habitual snoring and excessive daytime sleepiness (EDS), sleepiness that interfered with work and with increasing ESS scores. Habitual snorers were 5.8 and 3.1 times more likely to report EDS in active and passive situations, respectively, compared to nonsnorers (all p&lt;0.01). It is concluded that habitual snorers, most of whom are probably unlikely to have frank sleep apnoea syndrome, are at substantial risk for daytime sleepiness. These findings add support to the hypothesis that simple snoring is not benign and underscores the need for further research on health outcomes associated with this prevalent condition.
BOOKS REVIEWS
Authors: C. Fabian
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOKS REVIEWS Get access Breast Cancer Treatment: A Comprehensive Guide to Management Carol Fabian Carol Fabian University of Kansas Medical Center3901 Rainbow Blvd. Kansas City, KS 66160 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 12, 17 June 1992, Pages 975–976, https://doi.org/10.1093/jnci/84.12.975-a Published: 17 June 1992
Abstract C15: Telomere length assessment in human archival tumor tissues by quantitative PCR method
Authors: Hui Wang, Ning Go, Zhu Pirot, Katia Bassett
Journal: Cancer Research (2011)

Abstract Telomeres are essential for maintenance of genomic stability. Short telomeres have been associated with genomic instability, and initiation and progression of human cancers. To protect their telomeres, up to 90% of human cancers activate telomerase. Inhibition of telomerase by imetelstat, a specific and potent inhibitor, has resulted in telomere shortening, as well as tumor response in animal models. We propose that tumors with short telomeres may be more responsive to imetelstat than tumors with long telomeres. This hypothesis will be tested by measuring baseline telomere lengths in archival tumors of patients in imetelstat Phase II clinical trials, and correlating tumor telomere length with clinical outcome. In order to accomplish this, a fast, high-throughput qPCR-based method for telomere length measurement in genomic DNA extracted from FFPE tissue sections was developed. Using this assay, telomere repetitive DNA sequences and single-copy gene control were successfully amplified. The assay required very little genomic DNA (1–10ng per PCR reaction). Thus, small tissue sections (20 mm2) could be easily accommodated. Using this technique, we were able to perform the first comparison of relative telomere lengths in 22 human breast cancer samples and 8 human tumor cell lines in matched fresh-frozen and FFPE samples. Telomere lengths measured in FFPE samples by the qPCR method strongly correlated with the telomere lengths measured by TRF in matched fresh-frozen samples. Therefore, our method provides a useful tool for assessment of telomere length as a potential predictive biomarker of responsiveness to telomerase inhibition in clinical archival tumor tissue. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr C15.
Clinical outcomes and 30-day mortality following significant upper gastrointestinal bleeding in users of anti-platelet agents and non-steroidal anti-inflammatory drugs
Authors: A. S. Taha, C. McCloskey, T. Craigen, W. Angerson
Journal: Gut (2011)

<h3>Introduction</h3> The use of antiplatelet agents for vascular protection continues to increase and this has been associated with serious complications including upper gastrointestinal bleeding (UGIB). The clinical outcomes following such complication remains poorly understood. We, therefore, aimed to measure 30-day mortality and other clinical outcomes in patients presenting with UGIB while using antiplatelet agents as compared with those using non-steroidal anti-inflammatory drugs (NSAIDs) and those using neither of these agents. <h3>Methods</h3> Patients were included in the analysis if they presented with haematemesis and/ or melaena and had an endoscopic abnormality to explain their UGIB. Patients were excluded if they were well enough not to require hospital admission or if they had oesophageal or gastric varices. The Charlson and the complete Rockall scores were used to measure comorbidity and assess UGIB, respectively. Death of any cause within 30 days of UGIB was recorded. Drug therapy was noted including NSAIDs and antiplatelet drugs (low-dose aspirin, clopidogrel, dipyridamole and warfarin). The χ<sup>2</sup> test for categorical variables and Kruskal-Wallis test for continuous variables were used. <h3>Results</h3> 990 patients entered the analysis. Their characteristics and outcomes are shown in table 1. <h3>Conclusion</h3> Patients with UGIB and taking antiplatelet drugs, with or without NSAIDs, stay longer in hospital, are more likely to require transfusion and to die within 30 days after UGIB. They are also older and have higher comorbidity and Rockall scores than bleeders not taking NSAIDs or anti-platelet agents.
Evaluation of Lead Levels in Children Living near a Los Angeles County Battery Recycling Facility
Authors: Amy Rock Wohl, Adrian Dominguez, Peter Flessel
Journal: Environmental Health Perspectives (1996)

This cross-sectional study examined the association between environmental lead measurements surrounding a Los Angeles County battery recycling facility and the blood lead levels of the children living nearby. Environmental lead measurements and blood lead levels of young children living in a community adjacent to a stationary lead source were compared to those living in a community without a stationary lead source. Predictors of blood lead level were identified. The blood lead levels of the children living near the secondary lead smelter were within the normal range (< 5 micrograms/dl). The absence of ground cover was associated with slightly increased blood lead levels; however, this increase was not of biological significance. Lead levels in surface soil near the stationary lead source were elevated compared to the control community; however, the soil affected community, which may be due in part to controls recently installed at the stationary lead source.
CARCINOMA OF THE MALE BREAST
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Condoms as physical and chemical barriers against human immunodeficiency virus
Authors: C. A. Rietmeijer
Journal: JAMA (1988)

In an in vitro model, 20 condoms containing 0.9 mL of 6.6% (vol/vol) nonoxynol 9 and ten condoms without nonoxynol 9 were tested as physical and chemical barriers against human immunodeficiency virus (HIV). Each condom was mounted on a hollow dildo and placed in a glass cylinder. The HIV inoculum and HIV-free medium were placed on opposite sites of the condom. Intercourse was simulated by pumping the dildo up and down in the cylinder before and after deliberate rupture of the condom. Samples for HIV culture were taken from outside and inside the condom, before and after rupture. After rupture of nonoxynol 9—containing condoms, an outside nonoxynol 9 concentration of 0.25% was reached. No condom without nonoxynol 9 leaked HIV before rupture, but after rupture HIV could be detected in medium outside of seven of ten condoms tested. In none of 20 nonoxynol 9—containing condoms could HIV be detected in outside medium after rupture. Thus, undamaged condoms provide an effective physical barrier against HIV, and nonoxynol 9 may provide an effective chemical barrier as well. (<i>JAMA</i>1988;259:1851-1853)
Abstract 4627: Mutant p53 regulation in a Li-Fraumeni mouse model
Authors: Tamara Terzian, Molly Plehaty, Nema Sobhani, Wanida Stevens, Stefan Marasligiller, Tara Srinivas, Rohan Mylavarapu, Yvonne Clarke, Farinaz Arbab, Brendon Podell, Roderick Bronson
Journal: Cancer Research (2019)

Abstract The p53 tumor suppressor is maintained mainly at low physiological levels in normal cells by its two major inhibitors, Mdm2 and Mdm4. Mdm2 is a E3 ubiquitin ligase while Mdm4 binds to p53 and inhibits its transactivation activity. Deletion of either inhibitor results in p53-dependent embryonic lethality in mice. p53 is one of the most commonly mutated genes in human cancer. While we have gained considerable knowledge about wild-type p53 regulation and mode of action, our understanding of the oncogenic activity of mutant p53 lags behind. We know that mutant p53 is regulated in the same manner as wild-type p53. In a mouse model of Li-Fraumeni syndrome, Mdm2 binds and inhibits the hot spot mutant p53R172H (p53R175H in humans). Here we show that Mdm4, like Mdm2, regulates p53R172H stability in vivo, and that endogenous Mdm2 cannot compensate for this stabilization. Thus, mutant p53 mice that lack Mdm4 have stable high levels of p53R172H and display accelerated tumor development and an increased range of tumor types, compared to mutant p53 mice. Furthermore, when we compared mutant mice with the loss of two different alleles of both negative regulators, Mdm2 and Mdm4, we observed an even higher level of p53. This finding reveals that several tissues can tolerate high expression of oncogenic p53 and indicates a collaborative activity of these inhibitors in regulating mutant p53. The analysis of these mice uncovered new and unexpected functions of mutant p53 that we will discuss for the first time at the AACR 2019 meeting. Citation Format: Tamara Terzian, Molly Plehaty, Nema Sobhani, Wanida Stevens, Stefan Marasligiller, Tara Srinivas, Rohan Mylavarapu, Yvonne Clarke, Farinaz Arbab, Brendon Podell, Roderick Bronson. Mutant p53 regulation in a Li-Fraumeni mouse model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4627.
Comparison of the risk of hepatocellular carcinoma in nucleos(t) ide analogue-naive chronic hepatitis B patients treated with entecavir versus tenofovir : a systematic review and meta-analysis
Authors: Hyunwoo Oh, Yoon Jun Kim, Cheol-Hyung Lee, Minseok Albert Kim, Heejoon Jang, Sun Woong Kim, Yun Bin Lee, Eun Ju Cho, Jeonghoon Lee, Su Jong Yu, Jung-Hwan Yoon
Journal: Journal of Hepatology (2020)
Origin of mammalian gonadotropin-releasing hormones
Authors: N. M. Sherwood
Journal: Endocrine Reviews (1993)

GONADOTROPIN-releasing hormone (GnRH) plays a pivotal role in reproduction. The existence of this neuropeptide, also called LHRH, was predicted in the 1950s (1), but the structure of the 10 amino acid peptide for porcine and ovine brains was not reported until the 1970s (2, 3). In the 20 yr since then, only one form of GnRH has been identified in most placental mammals, and this is still considered to be the sole neuropeptide causing the release of LH and FSH. The structure and functions of the mammalian form of GnRH have been reviewed a number of times (4s–8). Meanwhile, both mammalian GnRH and related forms of GnRH are now known to be present in primitive placental mammals, nonplacental mammals, and other vertebrates. Novel functions, in addition to the release of gonadotropins, exist. Studies of GnRH peptides and their genes have altered our views on the origin, function, and regulation of this neuropeptide.
NIGHT BLINDNESS
Authors: None Captain
Journal: JAMA (1934)

<h3>To the Editor:—</h3> The case report of Drs. Wilbur and Eusterman on the subject of night blindness (The Journal, February 3, p. 364) is of more than ordinary interest. I entered the navy when all the sailing ships had not yet disappeared from active commission; in fact, my first cruise was on such a ship, and there I listened in the ward room to remarkable stories of night blindness and moon blindness alleged to have appeared among the crews of merchant ships. At the time I swallowed these stories with a grain of salt, but later as I became more familiar with the writings of the ancients I was struck with the more or less common occurrence of descriptions of this disease among the earliest Greek, Arabic and Latin writers. Hippocrates describes the disease in the second book of Prorrhetics. He says: It is most apt to attack the young
Clinical Neurocardiology
Authors: Eliot Schechter
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes7 March 2000Clinical NeurocardiologyEliot Schechter, MDEliot Schechter, MDUniversity of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. (Schechter)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-5-200003070-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Caplan LR, Hurst JW, Chimowitz MI. 494 pages. New York: Marcel Dekker; 1999. $195.00. ISBN 0824719913. Order phone 800-228-1160.Field of medicine: Clinical cardiology and neurology.Format: Hardcover book.Audience: Cardiologists, neurologists, and pediatricians.Purpose: To provide concise information on neurologic problems in patients with cardiac diseases.Content: The first chapters address cerebral embolism, effects of cardiac drugs, and complications of cardiac surgery and interventions in patients with cardiac problems. A useful discussion of coronary disease in patients with carotid disease follows. An exhaustive chapter on cardiac problems in patients with neurologic diseases describes 78 neurologic syndromes, ranging from the ... Author, Article, and Disclosure InformationAffiliations: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. (Schechter) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 March 2000Volume 132, Issue 5Page: 424KeywordsCardiac surgeryDrugsHeart diseasesMuscular dystrophiesNervous systemNeurocardiologyNeurologySoftware toolsStrokeThyroid diseases ePublished: 15 August 2000 Issue Published: 7 March 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Author reply
Authors: Elliott H. Sohn, Robert Wang, Russell Read, Athena Roufas, Livia Teo, Ramana Moorthy, Thomas Albini, Daniel Vasconcelos-Santos, Laurie Dustin, Soon-Phaik Chee, Ehud Zamir, Peter McCluskey, Ronald Smith, Narsing A. Rao
Journal: Ophthalmology (2012)
Thrombotic trombocytopenic purpura. Survival in pregnancy with heparin sodium therapy
Authors: J. H. Richardson
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Treatment
Authors: Mary E. Costanza
Journal: JAMA (1981)

The multidisciplinary nature of cancer treatment is well emphasized and described in this book. The recurrent strategy is an interweaving of surgery, radiation therapy, chemotherapy, and immunotherapy. A compendium of modern-day therapy,<i>Cancer Treatment</i>contains more than 5,000 references. An effort almost entirely completed by the faculty and staff at UCLA,<i>Cancer Treatment</i>is a comprehensive, useful, and relevant text for the oncologist. The book is organized essentially according to specific neoplasm. Two additional sections include a few brief chapters on general principles and another brief section on the management of selected complications of cancer and cancer treatment. The introductory section on general principles is abbreviated and simplistic, with the exception of the chapter on drugs used in chemotherapy, written by the editor, Dr Haskell. This is a fairly standard and complete review of "practical" pharmacology, a welcome synopsis for the practitioner. The final section on select complications contains some
Data Error in Results
Authors: Clifford Jack
Journal: JAMA Neurology (2020)

Rebecca F. Gottesman, MD, PhD; Thomas H. Mosley, PhD; David S. Knopman, MD; Qing Hao, MD, PhD; Dean Wong, MD, PhD; Lynne E. Wagenknecht, DrPH; Timothy M. Hughes, PhD; Ye Qiao, PhD; Jennifer Dearborn, MD, MPH; Bruce A. Wasserman, MD
CHRONIC DRACUNCULOSIS.
Authors: C. HODGSON, D. F. BARRETT
Journal: British Journal of Dermatology (1964)

Journal Article CHRONIC DRACUNCULOSIS. Get access C. HODGSON, C. HODGSON Department of Dermatology. The General Hospital. Steelhouse Lane, Birmingham 4 Search for other works by this author on: Oxford Academic Google Scholar D. F. BARRETT D. F. BARRETT Department of Dermatology. The General Hospital. Steelhouse Lane, Birmingham 4 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 5, 1 May 1964, Pages 211–217, https://doi.org/10.1111/j.1365-2133.1964.tb14512.x Published: 01 May 1964