tbuckley/cabot-search huggingface dataset:
FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer
Authors: C. Thussbas, J. Nahrig, S. Streit, J. Bange, R. Kates, K. Ulm, M. Kiechle, H. Hoefler, A. Ullrich, N. Harbeck
Journal: Journal of Clinical Oncology (2006)

625 Background: Bange et al. recently found that a single-nucleotide polymorphism (SNP) at codon 388 of fibroblast growth factor receptor 4 (FGFR4) gene, causing a transmembrane domain missense mutation (Gly388Arg), is associated with outcome in node-positive breast cancer. Methods: This study addresses clinical relevance of this SNP, FGFR4 genotype, phenotype, and HER2 regarding patient outcome and influence of adjuvant systemic therapy in a substantial primary breast cancer collective (n=372; 1987–2002), median follow-up 94.5 months. Treatment was administered according to consensus recommendations at the time: 73 patients (all N0) received no adjuvant systemic therapy; 114 received adjuvant chemotherapy (87% CMF-based), 164 tamoxifen, 10 combined chemo-endocrine therapy, 11 unknown. 128 (36%) patients experienced disease recurrence, 104 (81%) distant relapses; 140 (38%) died. PCR-RFLP-analysis of germ-line polymorphism was performed in uninvolved lymph nodes; FGFR4 and HER2 expression were assessed immunohistochemically in tumor tissue arrays. Primary endpoint was DFS, since it best reflects impact of adjuvant systemic therapy. Results: In 51% of patients, homo- or heterozygous Arg388 allele was present. No correlation existed between FGFR4 genotype and expression or HER2 status. In N0 patients, FGFR4 genotype was not correlated with disease outcome. In N+ patients, however, FGFR4 Arg388 was significantly associated with poor DFS (p=0.02) and OS (p=0.04). Notably, this association seems to be attributable to relatively poor therapy response in Arg388 carriers, reflected in their significantly shorter DFS (p=0.02) and OS (p=0.045) among patients receiving adjuvant systemic therapy. It is also seen as a significant interaction term in a multivariate proportional hazards model with Arg388 carriers having only about half as much benefit from adjuvant systemic therapy as wild-type carriers. Conclusions: Our results show that the previously found association of FGFR4 Arg388 genotype with breast cancer progression is strongest in patients with adjuvant systemic therapy, particularly chemotherapy, and thus may reflect therapy resistance. No significant financial relationships to disclose.
有关指甲银屑病的随机对照试验的结果报告:一种系统性回顾
Authors: C.I. Busard, J.Y.C. Nolte, M.C. Pasch, P.I. Spuls
Journal: British Journal of Dermatology (2018)

皮肤疾病(银屑病)的重要并发症之一就是指甲外观的变化。这些变化包括指甲表面形成小坑、疼痛的指甲板与基础甲床的分离,以及指甲本身的增大和增厚。考虑到外观的各种变化,研究人员在评估治疗结果时应使用简单但准确的标准来衡量治疗的银屑病指甲的变化;这称为核心结果集合。这篇由来自荷兰阿姆斯特丹大学和奈梅亨大学皮肤医学系的调查人员组织的研究调查了65项专注于指甲银屑病的临床试验,所有这些试验均采用了评估措施来衡量银屑病指甲的变化,其中最普遍的措施称为指甲银屑病严重程度指标。然而他们发现,各种研究中使用了若干不同的方法。一项针对这些研究的详细分析指出了这些方法中的许多差异,这导致不同治疗的结果难以进行比较。这尤其是因为缺乏用于表述研究中发现的指甲疾病严重程度最终分数的标准方法,而且严重程度的不同方面的评级也都不相同。其中一些评估打分系统甚至没有经过验证(证实)。作者们呼吁业界重新考虑所使用的银屑病指甲评估方法并重点指出需要开发能够经得起检查的新方法。这些方法应使调查人员能够以标准的方法评估病甲中的不同变化,从而使不同研究的结果具备可比性。他们建议组建一个共识小组来执行此项工作。
Accidental Hypothermia
Authors: Douglas J.A. Brown, Hermann Brugger, Jeff Boyd, Peter Paal
Journal: New England Journal of Medicine (2012)

Advances in rewarming have improved the prognosis for patients with hypothermia, especially those with cardiac arrest treated with extracorporeal rewarming. This review covers prehospital care, transport, resuscitation fluids, and extracorporeal membrane oxygenation.
Management of resistant lung cancer malignant pleural effusion by intrapleural gene therapy
Authors: K. Zarogoulidis, T. Kontakiotis, A. Papagiannis, A. Xafenias, A. Kortsaris
Journal: Journal of Clinical Oncology (2004)

3168 Background: Cytosine deaminase, transferred into tumour cells by an adenovirus vector, can convert the antifungal drug flucytosine to the antimetabolite 5-fluorouracil, which kills not only the transfected tumour cells but also their neighbours by the so-called 'bystander' effect. We used this technique in the management of lung cancer patients with malignant pleural effusion Methods: We used this technique in the management of six lung cancer patients with malignant pleural effusion, confirmed either histologically or pathologically. Two patients suffered from small cell lung cancer, which had relapsed after completion of initial chemotherapy, and four patients from adenocarcinoma of the lung that had progressed during chemotherapy procedure. The pleural fluid was drained through intercostal tube, and the treatment procedure was performed when the daily fluid production was less than 200 ml. A total amount of 1012 pfu of adenovirus vector was instilled into the pleural cavity either in a single dose (in four patients) or in two fractions (in two patients, given on the 1st and 7th day). All patients received flucytosine (Ancotil - Roche) 500 mg qds for 14 days Results: In two of the six patients reaccumulation of the fluid stopped within two weeks (one with an adenocarcinoma and the other with SCLC -treatment only by AdCD) and the drain was removed. These two patients died (after 3 and 22 months respectively) because of disease progression without evidence of pleural effusion. The main constitutional toxicity in all patients was fever due to the AdCD. Three patients experienced grade 3 neutropenia due to the concurrently given chemotherapy Conclusions: Intrapleural gene therapy may be a useful adjunct to chemotherapy in the management of refractory pleural effusions associated with lung cancer. No significant financial relationships to disclose.
Human RhDel Is Caused by a Deletion of 1,013 bp Between Introns 8 and 9 Including Exon 9 of RHD Gene
Authors: Jan-Gowth Chang, Jyh-Chwan Wang, Tzu-Yao Yang, Kun-Wu Tsan, Mu-Ching Shih, Ching-Tien Peng, Chang-Hai Tsai
Journal: Blood (1998)
Author Index
Authors: Abadeh Armin, Elissa Abrams, Abreu-Ram Irez, Seema Aceves, Catalina Acosta, John Adams, Justine Ade, Juhishree Adhikari, Ozge Aktas, Al-Shaikhly Taha, Cristina Alava, Alava Cruz, Alberto Nazoneth, Annette Aldous, Alexis Andrew, Maria Katerina, Alfaya Arias, Reza Alizadehfar, Almeida Prado, Meireles Laubi, Almqvist Alpern, Katherine Altman, Alvarez-Arango Santiago, Norman Anderson, Milena Andrade, Andraden Garban, Patricia Alejandra, Antuna Kristina, Juliana Apostolico, Andrea Apter, Ariza Veguillas, Amy Arneson, Nonie Arora, Anna Arroyo, Luisa Karla, Nathan Avaritt, Avinashi Vishal, Avramenko Yanina, M Andrea, Bruna Azevedo, Veronica Azmy, B€ Ackman, Jacquie Badiou, Jana Badrani, Maria Baeza, Mary Baker, Baldwin James, Ballesteros Benavides, Ga Ban, Joanne Band, Banerji Aleena, Erin Banta, Tina Banzon, Barrios Albajar, Barrios Del Pino, Graciela Benedetti, Antonia Bennett, Bensko Jillian, Ana Berglind, Cecilia Berin, Bezditko Tetyana, Biagini Myers, Robert Bissonnette, Jaclyn Bjelac, Suzanne Blackley, Andrea Blackman, Blanca Opez, Blanca -Lopez, Jonathon Blau, Whitney Block, G Bogas, Catherine Bollard, Catherine Bolster, Jonathan Boomer, Larry Borish, Samantha Bothwell, Danielle Bottalico, Louis-Philippe Boulet, Willis Bowman, Joshua Boyce, Jillian Bracaglia, Nicole Brackett, Jaqueline Brandão, Larissa Brandão, Brand Ão, Val Eria, Brandoni Petrone, Marianela Managua, Donna Brassil, Albert Bredenoord, Briggs-Steinberg Courtney, Sebastian Brill, John Brinton, Anna Bronoff, Irina Bronova, Anthony Brown, Jessica Brown, Kari Brown, Randall Brown, Joshua Brownell, Becky Buelow, Roberto Bueno, Yulia Bukina, Jill Buonanno, Joseph Butterfield, Adam Byrne, Stephanie Byrum, Cabrero Manresa, Katherine Cahill, Katherine Caid, William Calhoun, Juliana Camargo, Cameron Scott, Ronna Campbell, Brian Campfield, Capriles Hulett, Renata Cardili, Fabio Carmona, Laurie Carpenter, Donna Carstens, Deanna Caruso, Antonella Casola, Josefina Castagnoli, Fabio Castro, Ching Chan, Paul Chan, Angela Chang, Hsing-Yuan Chang, Mei Chang, L25 Chason, Alexandra Chastant, Abigail Chatfield, Amity Chavez, Mirna Chehade, Yudi Chen, 461a Chen, Brian Cheng, Nam Cheng, Sergio Chiarella, R Chinthrajah, Chitty -Lopez, Hyun-Ju Cho, Sun Choi, Madeleine Chollet, Chong Neto, Stephanie Christenson, Helen Chu, Chien-Chia Chuang, Yoon Hong, Annika Chura, Christina Ciaccio, Antonella Cianferoni, Haley Cirka
Journal: Journal of Allergy and Clinical Immunology (2021)
Experimental production of human "blue velvet" and "red devil" lesions
Authors: H. E. Puro
Journal: JAMA (1966)

ONE of the medical complications of the intravenous use of narcotics by addicts is the development of pulmonary hypertension due to arteritis and thrombosis of small pulmonary arteries, arterioles, and capillaries. We recently reported such a case in which a 32-year-old Negro woman with cor pulmonale died of severe pulmonary hypertension.<sup>1</sup>The pulmonary vessels showed thrombosis of varying duration. Many crystalline foreign bodies, identified as talc crystals, were found in the pulmonary vessels. The patient was a narcotic mainliner who had been injecting herself with a mixture known as "blue velvet" consisting of concentrated paregoric to which had been added a crushed tripelennamine (pryribenzamine) hydrochloride tablet. The offending agent was identified as talc in the tripelennamine tablet. We have recently observed "red devil" addiction in the Detroit area. This type of addiction consists of injecting the contents of secobarbital (Seconal) capsules intravenously. In this form of addiction starch from
Mandatory National Health Service
Authors: Stephen A. Vaughn
Journal: JAMA (1993)

<h3>To the Editor.</h3> —I am concerned by the Editorial by Dr Johns<sup>1</sup>supporting mandatory national health service by young physicians. Johns proposes financial incentives for attracting physicians into primary health care in underserved populations. As a student planning this career, I find his suggested incentives enticing. But mandatory service is a mistake. It kills incentive and interest. The practice of medicine has little leeway for the bored or uninterested physician. Enforced altruism is a dangerous oxymoron. It is a euphemism for bureaucratic control, the antithesis of "society's primary measures of what makes a physician special: competence, compassion, and dedication to improving the health of humanity."<sup>1</sup> To quote the famous mythical physician, Benjamin "Hawkeye" Pierce, when asked how a person so irresponsible, careless, and immature as himself managed to make it into "this man's army," he responded, "I was drafted."
HAZARDS OF ANTIBIOTIC FEED SUPPLEMENTS
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology and Public Health. A Text and Reference Book for Physicians, Medical Students and Health Workers.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pancreatitis with Biliary Disease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group
Authors: M. R. Karagas
Journal: JAMA (1992)

<h3>Objective.</h3> —The primary aims of this study were to assess risk of subsequent basal and squamous cell skin cancer among patients with a prior history of these tumors and to examine these risks in relation to patient characteristics and life-style factors. <h3>Design.</h3> —Follow-up of participants in a randomized trial of betacarotene as a possible skin cancer preventive agent. <h3>Setting.</h3> —Clinical centers in Los Angeles, Calif, San Francisco, Calif, Minneapolis, Minn, and Hanover, NH. <h3>Participants.</h3> —Patients (n=1805) who were diagnosed as having a basal or squamous cell skin cancer between January 1980 and February 1986 and were free of skin cancer at study entry. <h3>Main Outcome Measure.</h3> —Time from study entry to first new occurrence of basal and squamous cell skin cancer. <h3>Results.</h3> —The estimated risk of developing one or more new skin cancers was 35% at 3 years and 50% at 5 years. New skin cancers tended to be of the same cell type as the previous skin cancers. For both basal and squamous cell skin cancer, risk was higher among patients who were male, were over the age of 60 years, had more prior skin cancers, had severe actinic skin damage, or who burned easily with sun exposure. Compared with those who had never smoked, the rate of subsequent squamous cell skin cancer was higher among current smokers (rate ratio, 2.01; 95% confidence interval,1.21 to 3.34) and former smokers (rate ratio,1.62; 95% confidence interval, 1.07 to 2.47) and increased with both duration and amount smoked. There was no clear relationship between smoking and basal cell skin cancer; the rate appeared lower among heavy smokers but was unrelated to duration of smoking. <h3>Conclusions.</h3> —Persons with a prior nonmelanoma skin cancer had a substantial 5-year risk of developing another tumor of the same histologic type. Number of previous skin cancers, solar damage, and skin sensitivity to sun exposure were particularly related to this risk. The increased risk of squamous cell skin cancer associated with cigarette smoking merits further study. (<i>JAMA</i>. 1992;267:3305-3310)
Effect of weight history on ability to lose weight after a 6-month randomized controlled weight loss trial in overweight breast cancer survivors: The lifestyle, exercise, and nutrition (LEAN) study.
Authors: Tara Beth Sanft, Maura Harrigan, Brenda Cartmel, Mary Playdon, Yang Zhou, Erikka Loftfield, Melinda Irwin
Journal: Journal of Clinical Oncology (2014)

e20591 Background: Because obesity portends a higher risk of breast cancer mortality, achieving a healthy weight is recommended for breast cancer survivors. The impact of weight history on the ability to lose weight is unclear. We previously reported a 6.2 + 0.7% vs. 2.1 + 0.9% weight loss (p = .0003) in 100 breast cancer survivors randomized to a 6-month weight loss intervention vs. usual care. We examined whether weight history modified the effect of the intervention on body weight changes. Methods: Breast cancer survivors with a BMI > 25 kg/m2 were randomized to usual care or 6-month, 11-session diet and exercise-counseling intervention. Baseline and 6 month weight and height were measured; weight at ages 18 and 35, 5 years and 1 year before and at diagnosis were self-reported. We defined weight history as: 1) change in weight between each time point and baseline; and 2) duration of obesity (i.e., number of years of having a BMI > 30 between age 18 and baseline). Generalized linear models were used to evaluate mean changes at 6 months between the intervention and usual care groups, adjusted and stratified by weight history variables. Results: Mean age and time since diagnosis were 59 + 7 years and 2.9 + 2.1 years, respectively. BMI increased over time (age 18 BMI = 21.8 + 2.9; baseline BMI = 32.4 + 6.5). Number of years being obese was 5.3 + 8.2 years (range 0-40 years). BMI at baseline, change in BMI from various time points to baseline, and years of obesity did not modify weight loss results. After adjusting for weight history, women randomized to intervention vs. usual care lost 6.1 + 0.7% vs. 2.0 + 0.9%, p = .0006, respectively. Conclusions: Participants reported a history of steady weight gain over time. The duration of obesity did not modify weight loss results. Weight history did not hinder survivors’ ability to lose clinically meaningful weight via a structured intervention.
Quality of Life in Long-Term Survivors of Testicular Cancer: A Population-Based Case-Control Study
Authors: F. Joly
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To evaluate quality of life and social problems in long-term survivors of testicular cancer. PATIENTS AND METHODS: In 1998, 71 testicular cancer survivors (cases) identified from the Calvados General Tumor Registry were enrolled onto a case-control study. One hundred nineteen healthy control subjects (controls), matched by age and location of residence, were selected at random from electoral rolls. Three self-administered questionnaires were used: two health-related quality-of-life questionnaires (Short Form-36 and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 core questionnaires) and one life situation questionnaire. Specific questions concerning sexuality were also added. RESULTS: With a mean follow-up of 11 years, health-related quality-of-life scores did not differ significantly between cases and controls, nor did general symptom scores. Psychosocial problems were reported equally by cases and controls. Cases reported more modification of sexual life (P = .04) with decreased sexual enjoyment (P < .01), decreased desire (P = .02), and infertility (P < .01). Cases did not report more divorce than controls; they reported fewer changes in relationships with friends (P = .03). Although a similar proportion of cases and controls were at work, cases expressed less ambitious professional plans (P = .002). Cases had greater difficulty in borrowing from banks (P < .001). CONCLUSION: French long-term survivors of testicular cancer do not express more impairment of health-related quality of life or familial or professional life in comparison with healthy men. They did have more sexual life problems and found difficulty in borrowing from banks. This information should be used by practitioners to help their patients cope with their disease and return to normal life.
Deafness and Discharge from the Ear.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMINO ACID METABOLISM IN THE ISCHEMIC KIDNEY
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal