tbuckley/cabot-search huggingface dataset:
Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women
Authors: T. L. Paul
Journal: JAMA (1988)

The effect of long-term L-thyroxine (L-T<sub>4</sub>) therapy on axial skeleton bone density was studied in 31 premenopausal women; the bone densities of these women were compared with the bone densities of 31 age- and weight-matched women without thyroid or bone abnormalities. The women receiving L-T<sub>4</sub>therapy had been receiving the medication for a minimum of five years. There was no difference in calcium intake or excretion between the L-T<sub>4</sub>—treated women and the controls. Women receiving L-T<sub>4</sub>had increased serum thyroxine concentrations (134 ± 5 vs 95 ± 3 nmol/L [10.4 ± 0.4 vs 7.4 ± μg/dL]), an increased free thyroxine index (9.4 ±0.4 vs 6.8 ±0.2), and decreased serum thyroid-stimulating hormone concentrations (0.9±0.2 mU/L vs 2.1 ±0.3 mU/L [0.9±0.2 vs 2.1 ±0.3 μU/mL]). Serum thiodothyronine concentrations were normal and were similar in both groups. Women treated with L-T<sub>4</sub>had a 12.8% lower bone density at the femoral neck and a 10.1% lower bone density at the femoral trochanter compared with matched controls. In contrast, lumbar spine bone density was similar in the two groups. The data suggest that long-term L-T<sub>4</sub>therapy, which is often given at supraphysiologic dosages, may predispose patients to decreased bone density in the hip and may increase the risk of agerelated bone loss. It is advisable, therefore, to employ a dosage of L-T<sub>4</sub>that is carefully monitored to avoid the long-term use of dosages that are excessive for the thyroid condition being treated. (<i>JAMA</i>1988;259:3137-3141)
Intracranial calcification in nephrogenic diabetes insipidus
Authors: S. Kanzaki
Journal: JAMA (1985)

NEPHROGENIC diabetes insipidus (NDI) is a congenital hereditary disorder characterized by insensitivity of the renal tubule to antidiuretic hormone. This congenital hereditary disorder has been associated with a number of central nervous system complications.<sup>1,2</sup>However, intracranial calcification is an extremely rare complication of this disorder.<sup>3</sup>We describe a 2-year-old boy with NDI who presented with a unique pattern of intracranial calcification. Our case shows that NDI may result in organic brain damage if treatment is delayed. <h3>Report of a Case</h3> A boy 2 years 11 months old was admitted to our hospital because of a seizure. He was the product of a normal pregnancy, labor, and delivery of a 30-year-old, gravida 3, para 1, abortus 2 woman. The parents are not related and are of Japanese extraction. His birth weight was 2,900 g. He was given an Apgar score of 9 at both one and five minutes after
Lasker Awards Honor Three Researchers
Journal: Cancer Discovery (2017)

Abstract Three top cancer researchers were among recipients of the prestigious Albert and Mary Lasker Foundation awards. Douglas R. Lowy, MD, and John T. Schiller, PhD, were honored for research leading to the development of the first human papillomavirus vaccine. The prize for basic medical research went to Michael N. Hall, PhD, who discovered the TOR signaling pathway and its role in regulating cell growth and metabolism.
Prevalence and risk factors of artificial urinary sphincter revision in non-neurological male patients
Authors: I. Bentellis, M. El-Akri, J. Cornu, T. Brierre, T. Cousin, V. Gaillard, B. Poussot, H. Dupuis, N. Hermieu, D. Robin, A. Pitout, F. Beraud, P. Bertrand-Leon, D. Chevallier, F. Bruyere, X. Biardeau, H. Monsaint, L. Corbel, J. Hermieu, P. Lecoanet, G. Capon, X. Game, C. Saussine, M. Durand, B. Peyronnet
Journal: European Urology (2021)
Too many residencies and too many foreign graduates?
Authors: R. Tracy
Journal: JAMA (1972)

Should there be a close correlation between the number of US graduates and the number of first-year positions available in graduate medical education programs? The statistics in this issue of<i>JAMA</i>indicate a steadily increasing number of positions in most specialties, and also a steadily increasing number of graduates of foreign and US schools filling such positions, along with a substantial number of vacant positions. One thoughtful critic has urged that, with the phasing out of the free-standing internship by 1975, efforts should be made to bring about a concomitant reduction in the total number of house-staff positions, to provide for little more than the number of positions needed by the growing number of US graduates. Those who share this opinion believe that the vacancies in residencies attract foreign graduates, and that, by cutting the number of positions to the number of US and Canadian graduates available, the flow of
REGISTRATION
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estrogen Carcinogenesis in the Hamster Kidney: Role of Cytotoxicity and Cell Proliferation
Authors: Jonathan J. Li, Alfonso Gonzalez, Snigdha Banerjee, Sushanta K. Banerjee, Sara Antonia Li
Journal: Environmental Health Perspectives (1993)

Both natural and synthetic estrogens are capable of inducing renal neoplasms in Syrian ham- sters with an incidence approaching 100%/.Neither the sequence of events nor the mechanisms involved in estrogen carcinogenesis in this model have been established.Results presented here indicate that estrogen induces renal tubular damage in the hamster kidney that is pro- gressive and cumulative.Tubular injury was evident both as abnormal or lost microvilli, accu- mulation of cytoplasmic lipid droplets, vacuolization, and increases in secondary and tertiary lysosomes after 1.5 months of diethylstilbestrol (DES) treatment.Increasing tubular damage was evidenced by the detachment of tubular cells, cell debris, and occluded renal tubular lumens.In an effort to repair proximal tubular damage in the hamster kidney elicited by estro- gens, a 4.0-fold increase in proximal tubule BrdU labeling was evident at 4 months of DES or 170-estradiol (E2) treatment and in earlier estrogen treatment periods (1-3 months).During this period, there was a significant increase in aneuploid cells in the hamster kidney, the near diploid frequency increased more than 6.0-fold, and the near tetraploid frequency increased at least 3.0-fold between 1.5 and 3.5 months of estrogen treatment.Based on these data, the early sequence of events leading to estrogen-induced renal neoplastic transformation in the hamster is presented.
Reducing the impact of opportunistic infections in patients with HIV infection. New guidelines
Authors: J. E. Kaplan
Journal: JAMA (1995)

As many as 1 million individuals in the United States are infected with the human immunodeficiency virus (HIV).<sup>1</sup>For these persons, and especially for the approximately 250 000 who have severe immunosuppression as measured by a CD4<sup>+</sup>lymphocyte count below 0.20×10<sup>9</sup>/L (200/μL) (includes persons with [T. Green, PhD, Centers for Disease Control and Prevention (CDC), unpublished results, 1994] and without<sup>2</sup>AIDS-defining illnesses) opportunistic infections exact a heavy toll in terms of quality and length of life. Among patients with severe immunosuppression, the cumulative risk of serious opportunistic infection has been estimated to be 33% after 1 year and 58% after 2 years.<sup>3</sup>In addition to the morbidity and mortality associated with these opportunistic infections, treatment of these illnesses costs billions of dollars annually. The last 5 years have witnessed a gratifying surge in our knowledge of the environmental sources of opportunistic pathogens, ways to reduce
BREAST MILK AND RICKETS
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 667: A mouse model of APOE to define effects of doxorubicin on cognition
Authors: Tamar C. Demby, Yichien Lee, Olga Rodriguez, Christopher Albanese, Jeanne Mandelblatt, G. William Rebeck
Journal: Cancer Research (2019)

Abstract The purpose of this study was to establish the effects of Apolipoprotein E (APOE) genotype on cognitive function following doxorubicin treatment in a mouse model. Chemotherapy treatment can lead to cognitive impairment in cancer survivors, and, in older breast cancer survivors, APOE4 carriers have been shown to have higher risk for these impairments. Though APOE4 genotype is known as the strongest genetic risk factor for late-onset Alzheimer’s Disease compared to the APOE2 and APOE3 alleles, its effects on cognitive outcomes following treatment with common breast cancer chemotherapeutics are not yet well characterized. One year old female mice with targeted replacement of human APOE3 or APOE4 under control of the endogenous murine promoter were treated with 10 mg/kg doxorubicin or saline. Five weeks following treatment, spatial learning and memory was tested using the Barnes Maze. In APOE3 mice, doxorubicin treatment left spatial learning and memory intact. In APOE4 mice, doxorubicin treatment lead to impairment in spatial learning over the four days of training. This represents a promising model for studying the mechanisms behind cognitive impairment following doxorubicin treatment in a genetically vulnerable population. Citation Format: Tamar C. Demby, Yichien Lee, Olga Rodriguez, Christopher Albanese, Jeanne Mandelblatt, G. William Rebeck. A mouse model of APOE to define effects of doxorubicin on cognition [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 667.
Annexin II Interactions with the Annexin II Receptor Enhance Multiple Myeloma Cell Adhesion and Growth in the Bone Marrow Microenvironment,
Authors: Sonia D'Souza, Noriyoshi Kurihara, Yusuke Shiozawa, Jeena Joseph, Russell Taichman, Deborah Galson, David Roodman
Journal: Blood (2011)
Transposed Figure Numbering
Journal: JAMA Internal Medicine (2018)

Yousif Ahmad, MRCP; Sayan Sen, PhD; Matthew J. Shun-Shin, MRCP; Jing Ouyang, BA; Judith A. Finegold, MRCP; Rasha K. Al-Lamee, MRCP; Justin E. R. Davies, PhD; Graham D. Cole, MRCP; Darrel P. Francis, MD
H.11
Journal: CA A Cancer Journal for Clinicians (1970)

H.11After careful study of the liteurature and other information available to it, the American Cancer Society does not have evidence that treatment with H.11 results in objective benefit in the treatment of cancer in human beings.The following is a summary of informa tion on H.11 in the American Cancer Society files: TherapyAccording to a product brochure being distributed by Standard Laboratories, Ltd., Sunbury-On-Thames, Middlesex, England, in 1969, â€oe¿ H.11 Extract is pre pared from normal human male urine con centrated under reduced pressure at 60Â°C.The active principles are extracted from the concentrate with absolute ethanol at pH3 in successive phases, and later with ethyl ether.After neutralization the ex tract is dialysed and the total solid content reduced to 1.0%.The composition of H.11 Extract is: Polypeptide containing sul phonic acid and phenollic groupsâ€"0.1%;Amino acids, creatinine, and phenollic groups_0.9C/(,Sodium sulphiteâ€"0.1%,Phenolâ€"0.5/(.H.11 contains an active principle which is a polypeptide contain ing suiphonic acid and phenollic groups.It is a dark brown substance, the sodium salt of which is soluble in water.It is solu ble in ethanol, the lower aliphatic alcohols, 90% formic acid, and phenol.@â€oe¿ â€Ĩt is available as H.11 Extract for injection; H.11 Oral and 11.11 Elixir for oral use; and as H.11 Ointment and H.11 Supposi tories or Pessaries for adjuvant treatment.The brochure continued: â€oe¿ H.11 is non toxic, and produces no side-effects.The ad
Current Comment
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ILLINOIS MEDICAL PRACTICE ACT.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Council on drugs. List No. 95. New names
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Formaldehyde Exposure and Health Status in Households
Authors: I. Broder, P. Corey, P. Brasher, M. Lipa, P. Cole
Journal: Environmental Health Perspectives (1991)

This report describes a case study concerned with acute and subacute health effects of formaldehyde in the indoor air, which is based on a large group of control houses and houses retroinsulated 4 to 5 years earlier with urea formaldehyde foam insulation (UFFI). Both groups underwent an environmental and health assessment on two occasions separated by an interval of 12 months, during which about one-half of the UFFI group performed remedial work on their houses. The results show that in the first survey of the study population, before remedial work, there was a moderate excess of many adverse health status indicators among the UFFI subset relative to the controls. This was associated with the presence of direct exposure-response relationships between formaldehyde levels in the UFFI houses and the prevalence of a number of symptoms. No comparable relationships were seen among the controls. At the second survey, performed following the removal of the UFFI, there was an appreciable reduction in the excess of most adverse health status indicators among the UFFI subjects. This improvement in health status among the UFFI removal subset was not associated with any significant diminution of formaldehyde exposures, although the previously observed exposure-response relationships had vanished. These observations imply that the findings obtained in the preremedial stage of the study cannot be explained by formaldehyde exposure alone.
PRELIMINARY PROGRAMS.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COPY NUMBER VARIATIONS AND UNIPARENTAL DISOMY PREDICT POOR SURVIVAL IN PATIENTS WITH IDIOPATHIC CYTOPENIA OF UNDETERMINED SIGNIFICANCE AND ARE ASSOCIATED WITH MACROCYTOSIS
Authors: S. U. Mikkelsen, S. Safavi, J. W. Hansen, K. Dimopoulos, C. OʼRourke, M. K. Andersen, J. B. Andersen, K. Grønbæk
Journal: HemaSphere (2019)
Acute renal failure secondary to amoxapine overdose
Authors: A. J. Pumariega
Journal: JAMA (1982)

AMOXAPINE is a new antidepressant approved for marketing in the United States just over a year ago. It is structurally similar to both loxapine succinate and imipramine hydrochloride, and its mechanism of action is through blocking the reuptake of norepinephrine primarily and serotonin secondarily as well as having a dopamine-receptor blocking effect. It has become one of the most popular antidepressants in use today, largely because of its low incidence of side effects and toxic reactions and its possible earlier onset of action.<sup>1-5</sup>Our recent experience with a patient who ingested excessive amounts of this drug has alerted us to a yet unreported and potentially lethal complication of amoxapine overdose. <h3>Report of a Case</h3> A 17-year-old girl was transferred to Vanderbilt University Medical Center, Nashville, Tenn, from an outlying hospital after ingesting at least 4 g of amoxapine (approximately 60 mg/kg) in an impulsive suicide gesture. She had been
Angiographic Studies of Experimental Intracranial Hypertension
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal