tbuckley/cabot-search huggingface dataset:
Occupational Cancer in the European Part of the Commonwealth of Independent States
Authors: Mariana A. Bulbulyan, Paolo Boffetta
Journal: Environmental Health Perspectives (1999)

Precise information on the number of workers currently exposed to carcinogens in the Commonwealth of Independent States (CIS) is lacking.However, the large number of workers employed in high-risk industries such as the chemical and metal industries suggests that the number of workers potentially exposed to carcinogens may be large.In the CIS, women account for almost 50% of the industrial work force.Although no precise data are available on the number of cancers caused by occupational exposures, indirect evidence suggests that the magnitude of the problem is comparable to that observed in Westem Europe, representing some 20,000 cases per year.The large number of women employed in the past and at present in industries that create potential exposure to carcinogens is a special charactenstic of the CIS.In recent years an increasing amount of high-quality research has been conducted on occupational cancer in the CIS; there is, however, room for further improvement.International training programs should be established, and funds from international research and development programs should be devoted to this area.In recent years, following privatization of many large-scale industries, access to employment and exposure data is becoming increasingly difficult.
Chemolysis Through Kidney Irrigation Effective With Some Renal Calculi
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MODERN OPERATIONS FOR THE RADICAL CURE OF HERNIA.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TUBERCULOSIS CONFERENCE IN BERLIN
Journal: BMJ (1913)

500 miles to see Iliin.He lhad often been asked to explain lhis power,-but he lhad nothing to explain; he could only sav what happencd.He was convinCed, hiowever, that many otlher people besides Iimllself possessed it, if lnot to the same extent at least in a lesser degree, and in the proposed clinic tllere would be ani opportunity for thenii to exercise it witlh great utsefuilness.Dr. CONSTAN-CE LONG said that many doctors hiacl sulccessfully practised psycltotherapy, buit tup to the present there hiad been lno provision of tihis kiind of treatment for the poor.The object of the mnedico-psychological clinic, tlherefore, was to provide and equiip witlh suitable apparatus a smDall place wlhere treatmenit by psyclotlherapy m:iglht be obtained by the poorer classes, and( wNi-here inquirers wouild b)e providedl witlh opportuinities for stiudy and investigation.The patients would inielude people stufering from depression, insonnia, loss of sensation, tlle drug hlabit, morbid attenition to bodily ailments, and nmany otlher miianifesta- tions of ill h1ealthl for WhliChI no adequate provision existed at tthe present miomeent; wlhilst the treatmiient wou-Lldl coni- sist of perstuasion, suggestion, re-edutcation.psycho-anialvsis, indtuced sleep, and even hypnotism.It was particularly importanit for the public to iunderstand that the clinic would not be in opposition to ortlhodox m--edicine, but
The Mammalian Respiratory System and Critical Windows of Exposure for Children's Health
Authors: Kent E. Pinkerton, Jesse P. Joad
Journal: Environmental Health Perspectives (2000)

The respiratory system is a complex organ system composed of multiple cell types involved in a variety of functions.The development of the respiratory system occurs from embryogenesis to adult life, passing through several distinct stages of maturation and growth.We review embryonic, fetal, and postnatal phases of lung development.We also discuss branching morphogenesis and cellular differentiation of the respiratory system, as well as the postnatal development of xenobiotic metabolizing systems within the lungs.Exposure of the respiratory system to a wide range of chemicals and environmental toxicants during perinatal life has the potential to significantly affect the maturation, growth, and function of this organ system.Although the potential targets for exposure to toxic factors are currently not known, they are likely to affect critical molecular signals expressed during distinct stages of lung development.The effects of exposure to environmental tobacco smoke during critical windows of perinatal growth are provided as an example leading to altered cellular and physiological function of the lungs.An understanding of critical windows of exposure of the respiratory system on children's health requires consideration that lung development is a multistep process and cannot be based on studies in adults.
ELECTRO-THERMIC HEMOSTASIS IN ABDOMINAL AND PELVIC SURGERY.
Authors: ANDREW J. DOWNES
Journal: JAMA (1902)

At the last meeting of the American Medical Association, in a paper with the same title as the present one, I entered into the comparative merits in hemostasis of of the ligature, angiotripsy and electro-thermic pressure. Brief reference was made to the development of electro-thermic hemostasis in the crude application by Keith of a hot iron to the compressing blades of a pedicle forceps. Credit was given Dr. Skene for devising and using instruments with a heating medium concealed and insulated within one of the compressing blades, therefore, for the introduction of electro-thermic hemostasis. I stated that the essential element in this form of of hemostasis was a rapid source of heat in one blade of an instrument giving the proper amount of pressure. My own instruments were demonstrated, showing many points of improvement and practicability over Dr. Skene's. A limited number of cases with this method of hemostasis were
Suitability of fetal tissue for transplantation
Authors: M. Michejda
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The 6-month study of the suitability for transplantation<sup>1</sup>of fetal tissues derived from spontaneous abortions (SAbs) and ectopic pregnancies (EPs) was conceived and delivered in a very political climate. The question of the use of fetal tissue(s) from spontaneous vs elective abortions has been caught up in the political debate of pro-life vs prochoice issues, which also directly affects the scientific community. Unfortunately, the emotions and the lack of objectivity, as well as the lack of true scientific inquiry in certain quarters of the scientific community, have jeopardized the scientific integrity of the study even before it was initiated. The results reported in the aforementioned article represent data from five independent studies supported by National Institute of Child Health and Human Development and National Institutes of Health funds. The results reported in the article by Dr Branch and colleagues<sup>1</sup>on EPs confirmed our earlier prediction
Twentieth Century Practice: An International Encyclopedia of Modern Medical Science, by Leading Authorities of Europe and America.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Archives of Ophthalmology, Chicago
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PRESENT LEGAL ASPECT OF INEBRIETY AND CRIME.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The epidemiology of found experiments
Authors: D. F. Phillips
Journal: JAMA (1995)

In much scientific work, researchers construct an experiment in which they assign subjects to experimental or control groups. Sometimes, instead of constructing an experiment, researchers may find one that was created by natural or social events beyond the researchers' control. The study by Kark et al<sup>1</sup>in this issue of<i>JAMA</i>is one example of a "found" experiment. In this study the authors document an abrupt increase in mortality after the first Iraqi missile attack on Israel in January 1991. Found experiments of this sort have three characteristics: (1) the independent variable (eg, the presence or absence of a missile attack) shows a marked change in a short time; (2) the dependent variable (eg, mortality) also displays a large, abrupt change in level; and (3) the investigation seeks a short-term link between independent and dependent variables. For example, the present study found a sharp increase See also p 1208.
Statistics, History
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcoholism
Authors: J. D. Craig
Journal: BMJ (1952)

<h3>ABSTRACT</h3> Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic associated with key aspects of metabolic disease such as obesity and diabetes. The first stage of NAFLD is characterized by lipid accumulation in hepatocytes, but this can further progress into non-alcoholic steatohepatitis (NASH), fibrosis or cirrhosis, and hepatocellular carcinoma (HCC). A western diet, high in fats, sugars and cholesterol is linked to NAFLD development. Murine models are often used to experimentally study NAFLD, as they can display similar histopathological features as humans; however, there remains debate on which diet-induced model most appropriately and consistently mimics both human disease progression and pathogenesis. In this study, we performed a side-byside comparison of two popular diet models of murine NAFLD/NASH and associated HCC: a high fat diet supplemented with 30% fructose water (HFHF) and a western diet high in cholesterol (WDHC), comparing them to a common grain-based chow diet (GBD). Mice on both experimental diets developed liver steatosis, while WDHC-fed mice had greater levels of hepatic inflammation and fibrosis than HFHF-fed mice. In contrast, HFHF-fed mice were more obese and developed more severe metabolic syndrome, with less pronounced liver disease. Despite these differences, WDHC-fed and HFHF-fed mice had similar tumour burdens in a model of diet-potentiated liver cancer. Response to diet and resulting phenotypes were generally similar between sexes, albeit delayed in females. Notably, although metabolic and liver disease phenotypes are often thought to progress in parallel, this study shows that modest differences in diet can significantly uncouple glucose homeostasis and liver damage. In conclusion, long-term feeding of either HFHF or WDHC are reliable methods to induce NASH and diet-potentiated liver cancer in mice of both sexes; however, the choice of diet involves a trade-off between severity of metabolic syndrome and liver damage.
Government agencies act on task force findings
Authors: W. A. Check
Journal: JAMA (1986)

Since the Department of Health and Human Services was the source of the task force report on the health status of black persons and members of other minority groups, it is not too surprising that several of its agencies have been prompt to respond to the report's findings. For example, the National Heart, Lung, and Blood Institute, Bethesda, Md, has set up a study of risk factors for cardiovascular disease in the black population and a study of the development of obesity in black women. These studies, institute officials point out, respond to one of the needs identified by the tast force—that for better data collection as a first step in coping with the causes of health problems in minority populations. Institute officials say that only one study of hypertension has, to their knowledge, included enough black participants to allow conclusions about whether pharmacologic lowering of blood pressure reduces the
Guanabenz Overdose
Authors: SUSAN J. ROGERS
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 March 1986Guanabenz OverdoseSUSAN J. ROGERS, Pharm.D.SUSAN J. ROGERS, Pharm.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-445_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the June issue, Hall and colleagues (1) presented two case reports of patients with guanabenz overdose. They also mentioned that four unpublished cases of guanabenz overdose were reported to the manufacturer between 1975 and 1983 and that these particular patients all developed somnolence, coma, hypotension, and bradycardia. They state that three of these patients were treated with norepinephrine and atropine.To avoid possible misconceptions concerning the symptoms of guanabenz overdose, I want to clarify the following aspects of these four cases. Three of the four patients had somnolence, but only one developed coma and one became...Reference1. HALLSMOLINSKEKULIGRUMACK ASKB. Guanabenz overdose. Ann Intern Med. 1985;102:787-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Wyeth Laboratories Philadelphia, PA 19101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAmino Acids as Nonselective HerbicidesClonidine and Related Imidazoline DerivativesGuanabenz Induced Hypothermia in a Poisoned Elderly FemaleSilicon Nitride for Isolating Devices and Device Components 1 March 1986Volume 104, Issue 3Page: 445-445KeywordsAtropineBradycardiaComaHypotensionNorepinephrine ePublished: 1 December 2008 Issue Published: 1 March 1986 PDF downloadLoading ...
A randomized, double-blind, placebo-controlled study to assess the efficacy and toxicity of subcutaneous ketamine in the management of cancer pain.
Authors: David C Currow, Janet Hardy, Stephen Quinn, Belinda Fazekas, John Plummer, Simon Eckermann, Meera Agar, Odette Spruyt, Rowett Debra
Journal: Journal of Clinical Oncology (2012)

2604 Background: The dissociative anaesthetic ketamine is widely used for cancer related pain. A Cochrane review concluded that insufficient evidence was available to support its use in this setting. Methods: This phase III, multisite, double-blind, dose escalation, placebo, randomised controlled study aimed to determine whether ketamine, delivered subcutaneously over three to five days is more effective than placebo, when used in conjunction with adjuvant therapy in the management of chronic uncontrolled cancer pain. Ketamine would be considered to be of net benefit if it provided a reduction in average pain scores by ≥2/10 points from baseline, with limited breakthrough analgesia and acceptable toxicity. Results: For the 185 participants, there was no significant difference between the proportion of positive outcomes (0.04 (-0.10, 0.18) p=0.55) in the placebo and intervention arms (response rates 27% (25/92) and 31% (29/93)). Pain type (nociceptive versus neuropathic) was not a predictor of response. There was almost twice the incidence of adverse events worse than baseline in the ketamine group after day 1 (IRR = 1.95 (1.46, 2.61), p&lt;0.001) and throughout the study. Those receiving ketamine were more likely to experience a more severe grade of adverse event/day (OR=1.09 (1.00, 1.18), p=0.039). The number needed to treat for one additional patient to get a positive outcome from ketamine was 25 (6, ∞). The number needed to harm, because of toxicity-related withdrawal was 6 (4, 13). Conclusions: Ketamine does not have net clinical benefit when used as an adjunct to opioids and standard co-analgesics in cancer pain.
Correction
Authors: Yujie Li, Yongfeng Song, Meng Zhao, Yanjing Guo, Chunxiao Yu, Wenbin Chen, Shanshan Shao, Chao Xu, Xinli Zhou, Lifang Zhao, Zhenhai Zhang, Tao Bo, Yu Xia, Christopher Proud, Xuemin Wang, Li Wang, Jiajun Zhao, Ling Gao, Yang-Hsiang Lin, Meng-Han Wu, Ya-Hui Huang, Chau-Ting Yeh, Mei-Ling Cheng, Hsiang-Cheng Chi, Chung-Ying Tsai, I-Hsiao Chung, Ching-Ying Chen, Kwang-Huei Lin
Journal: Hepatology (2018)
Mortality From Abortion and Childbirth-Reply
Authors: David A. Grimes
Journal: JAMA (1983)

<h3>In Reply.—</h3> The Lanskas and Dr Rimm suggest that because cesarean delivery is more hazardous for women than vaginal delivery,<sup>1</sup>"maternal mortality caused by abortion should be compared with both vaginal delivery and cesarean delivery separately." Precise national data required to calculate these rates are unavailable; nevertheless, existing data<sup>2</sup>do not support the hypothesis that 90% of all maternal deaths are related to cesarean delivery. Moreover, the suggested comparison would not be clinically useful. Approximately 16%<sup>3</sup>of women in the United States who give birth do so by cesarean delivery; a pregnant woman choosing between abortion and childbirth usually cannot predict which type of delivery she will have. A woman who chooses to carry her pregnancy to delivery is subject to the risks inherent in the process, regardless of their source. Hence, the appropriate comparison is between the mortality rate associated with all methods of abortion and