tbuckley/cabot-search huggingface dataset:
THE BARBERS' COLLEGE
Journal: JAMA (1961)

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Abstract 1394: Sublethal Levels of Aldehydes Augmented Cardiac Anti-Oxidant Defense through Activation of eIF2 <i>α</i> -ATF4 Pathway via GCN2 Kinase
Authors: Takaharu Katayama, Motoaki Sano, Jin Endo, Kentaro Hayashida, Tomohiro Matsuhashi, Satori Tokudome, Toshimi Kageyama, Shinsuke Yuasa, Takeshi Adachi, Makoto Suematsu, Kiyomi Nishimaki, Ikuroh Ohsawa, Shigeo Ohta, Satoshi Ogawa, Keiichi Fukuda
Journal: Circulation (2008)

[Introduction] Despite an increase in the levels of aldehydes, the heart from aldehyde dehydrogenase ( ALDH ) 2*2 -transgenic (Tg) mice, loss of function model of ALDH, exhibited a greater tolerance to oxidative stress via activation of amino acid metabolism leading to glutathione biosynthesis. This study was designed to identify the signaling cascades responsible for the activation of amino acid metabolism by aldehydes. [Methods &amp; Results] (1) Phosphorylation of α -subunit of eukaryotic translation initiation factor 2 (eIF2 α ) and subsequent translational activation of ATF4 have been shown to induce amino acid metabolism as a common response to a wide variety of stressors. Consistent with this, phosphorylation levels of eIF2 α and protein expression of ATF4 were increased in ALDH2*2 -Tg hearts. (2) Among four eIF2 α kinases, general control non-depressible (GCN)2 kinase, a sensor for amino acid insufficiency, was activated in ALDH2*2 -Tg heart. (3) Quantification of intracellular amino acid demonstrated that free histidine concentration in ALDH2*2 -Tg heart was selectively reduced by 50% compared to that in non-Tg littermates. (4) To clarify the functional significance of observed reduction in histidine, ALDH2*2 -Tg mice were fed a high histidine diet. The phosphorylation levels of eIF2 α and the protein levels of ATF4 were diminished by 50% in ALDH2*2 -Tg mice fed the high histidine diet, in agreement with the normalization of histidine concentration. Accordingly, both enhanced tolerance to ischemia-reperfusion injury and elevated levels of glutathione were partially diminished in the heart from ALDH2*2 -Tg mice fed the high histidine diet compared to ALDH2*2 -Tg mice fed normal chow. (5) In culture, exposure to 4-hydroxy-2-nonenal (4-HNE) phosphorylated GCN2 and eIF2 α and increased protein levels of ATF4 in a time-dependent manner. (6) siRNA-mediated knockdown of GCN2 abrogated 4-HNE-induced induction of amino acid metabolic genes. [Conclusions] Activation of eIF2 α -ATF4 pathway via GCN2 kinase might be of special importance in the transcriptional control that coordinately promotes amino acid metabolism in response to aldehydes. Intracellular depletion of free histidine is at least partly involved in the activation of GCN2 kinase by aldehydes.
“OFFICIAL INFORMATION”—MEDICAL!
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The View
Authors: Floyd Skloot
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infanticide.
Authors: J. W. Hervey
Journal: JAMA (1889)

<h3>Dear Sir:</h3> —The members of the medical profession must have felt embarrassed and humiliated at the exposure of abortionists by the<i>Chicago Times</i>. We heartily endorse the remarks of the Editor ofThe Journalon that subject. The profession cannot be consistent with the sentiments of this editorial and permit one of these men, or any known infanticidist, to remain within any medical society recognized by the American Medical Association. Nor should any member of the profession recognize or consult with one of them. Permit your correspondent to say that our periodical literature has said but little, much too little, on this subject, to impress their readers with the enormity of this crime. We regret to express any opinion that will do injustice to any journal, but the truth of our convictions is, that some articles have been published by contributors to medical journals, that have come to my reading,
Aspirin-sulfinpyrazone in prophylaxis of deep venous thrombosis in total hip replacement
Authors: R. D. Sautter
Journal: JAMA (1983)

In postoperative hip arthroplasty patients, treatment with aspirin and sulfinpyrazone resulted in a statistically significant reduction of venographically diagnosed thrombi in the proximal veins of the leg. This reduction was most apparent in thrombi that involved the iliac vein. When compared with their placebo-treated counterparts, female patients who received the active treatment experienced a statistically significant 75% reduction of thrombosis, compared with a 32% reduction for men that was not statistically significant. There were no serious adverse effects. Factors were identified that may influence the result of drug prophylaxis trials in deep-vein thrombosis. (<i>JAMA</i>1983;250:2649-2654)
Commentaire de travail de A. V. Sahai et al., pp. 900
Journal: Endoscopy (2010)

See also: A prospective comparison of endoscopic ultrasound-guided fine needle aspiration results obtained in the same lesion, with and without the needle styletEndoscopy 2010; 42(11): 900-903DOI: 10.1055/s-0030-1255676
SPLENIC ENLARGEMENTS.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE FORTIETH ANNUAL MEETING OF THE AMERICAN MEDICAL ASSOCIATION.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peptic ulcer and piroxicam
Authors: W H W Inman, N S B Rawson
Journal: BMJ (1985)

AIDs and class II microbiological safety cabinets SIR,-The information about class II microbio- logical safety cabinets presented by Sheila McKechnie (30 March, p 1006) needs correction.She states "there is sound evidence that they provide little or no operator protection."Collins indicated that class II cabinets that satisfy the requirements of the National Sanitation Foundation Standard No 49 (1976) and British Standard 5726 (1979) are available and are effective.The most pertinent information indicating the effectiveness of class II cabinets is in a table from the recent National Institutes of Health slide series that accompanies the Fundamentals for safe Micro- biological Research, a series used to teach biosafety.Leak factors for safety cabinets* Type Activity Leak factor Class I None io06 to ItI Simulated labwork Or5 to 1t2 Class IIA None 10 to 106 Simulated labwork IY7 to 1O5 Class IIB None 1o9to Ior Simulated labwork 10 to o-5 Class III Transfer through autoclave 6104 *The leakage factors were arrived at by sampling outside while aerosols were inside.The data were collected by placing cabinets in a wind tunnel.All air passing the cabinet was collected in a large volume sampler.A leak factor of 10-6 implies that one out of every million particles generated in the cabinet would escape containment under normal operating conditions.
ASSOCIATION NEWS.
Authors: R. H. Plummer
Journal: JAMA (1894)

<b>The Association Train</b>will leave Chicago Monday, May 28, via Santa Fe R. R., Rio Grande Western, and Southern Pacific, for San Francisco via Denver, Colorado Springs, Leadville, Manitou, Glenwood Springs, Salt Lake, Ogden, Truckee and Sacramento. Returning, after the meeting, the train will pass through Sacramento and Northern California to Portland, thence east by way of the Northern Pacific R. R. to St. Paul. C. M. &amp; St.P. R. St. Paul to Chicago. A stop over at Yellowstone National Park for those who desire it has been arranged, and it has been understood that at several places on the journey there will be short stops. President Hibberd's party in a special car join the train at Chicago, and the St. Louis party are expected to join at Kansas City. From all points east and south, concentrating on this train should be effected at Chicago and St. Louis. For all
Jamestown Medical Clinic System
Authors: J. D. Voltmann
Journal: JAMA (1975)

Comprehensive health care can be provided in rural and poor areas despite a decreasing number of physicians in those areas. A single physician increased his productivity by 300% to 400% by combining already available resources: specially trained and supervised nurse-practitioners, problemoriented charting, and multiphasic screening. With emphasis on the nurse-practitioner as the main "person of contact" for the patient, the physician is able to shift from 50% to 75% of his usual tasks to these specially trained personnel. Patients have come to regard the physician as a "consultant" to the nurse-practitioner. (<i>JAMA</i>234:303-304, 1975)
Blocking PD-1 in Tumors with Faulty DNA Repair
Journal: Cancer Discovery (2016)

A phase II study shows that DNA mismatch repair deficiency can render tumors highly sensitive to the PD-1 inhibitor pembrolizumab. Patients with a range of solid tumors, including colorectal and endometrial cancers, with the deficiency responded well and durably to immune checkpoint blockade, with minimal toxicity.
OC-004 Thiopurine Induced Pancreatitis In Inflammatory Bowel Disease: Clinical Features And Genetic Determinants
Authors: GA Heap, A Singh, C Bewshea, MN Weedon, A Cole, T Creed, E Greig, P Irving, J Lindsay, J Mawdsley, Z Mazhar, T Orchard, D Reffitt, A Holden, T Ahmad
Journal: Gut (2014)

<h3>Introduction</h3> Pancreatitis is a rare, but important complication of thiopurine treatment. The aims of this project were to a) characterise the clinical features of thiopurine-induced pancreatitis and b) identify clinical useful genetic markers that might predict development of this serious adverse drug reaction. <h3>Methods</h3> Patients were identified and recruited from 172 sites (128 UK). Inclusion criteria included a) onset of acute severe abdominal pain within three months of starting thiopurine treatment b) ≥ two-fold rise in amylase or lipase c) medical opinion implicating thiopurine therapy and drug withdrawal. <h3>Results</h3> We recruited 303 patients. Following adjudication 48 cases classified as definite (recurrent pancreatitis on rechallenge) and 195 cases classified as probable (temporal relationship and no other cause for pancreatitis) were taken forward for analyses. 46% of patients were smokers at the time of development of pancreatitis. Patients were treated with a thiopurine for a median of 19 days (95% CI: 17 – 21) before development of pancreatitis. Most cases were mild, with only 5 cases developing single organ dysfunction. 70% of patients were hospitalised with a median length of stay of 4 days (95% CI: 3.2 – 4.8). Neither age (p = 0.08), drug dose (p = 0.11), BMI (p = 0.73) nor smoking (p = 0.59) predicted length of hospital stay or severity of pancreatitis in multivariate analysis. Using a control cohort of 4,109 Crohn's disease and ulcerative colitis cases we conducted a genome wide association study with these 239 patients. A significant variant was identified in the Class II MHC region (Odds ratio 3.03, p = 2.63 × 10–20). Dedicated HLA and 1000 genome project imputation refined the association within the MHC (R squared &gt; 0.8 and MAF &gt; 0.01). This association was robust to principle component correction. TPMT genotype was not associated with pancreatitis development (p = 0.99). A second cohort of 100 cases and 500 independent disease controls treated with thiopurines but screened for pancreatitis has been generated to confirm the association. <h3>Conclusion</h3> We describe the largest clinical characterisation of thiopurine-induced pancreatitis to date and use this cohort to undertake a pharmacogenetics genome wide association study that has identified a significant association within the Class II MHC region. <h3>Disclosure of Interest</h3> None Declared.
THE RADIOACTIVITY OF NATURAL WATERS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Roy Patterson, Douglas Johnstone, Henry Claman, Samuel Freedman, Lawrence Lightenstein, Sheldon Siegel, I Beksstein, Harold Friedman, Robert Orange, Richard Talamo, John Thompson, Rebecca Buckley, Sidney Leskowitz, Abraham Osler, New York, John Salvaggio, Kurt Bloch, Merrill Chase, New Pork, Jordan Fink, Bernard Levine, Charles Reed
Journal: Journal of Allergy and Clinical Immunology (1973)
Commentary
Authors: Chris Jarvis
Journal: British Journal of Sports Medicine (2001)

Background-OV road mountain biking is now an extremely popular recreation and a potent cause of serious injury.Aim-To establish the morbidity associated with this sport.Methods-Data were collected prospectively over one year on all patients presenting with an injury caused by either recreational or competitive oV road mountain biking.Results-Eighty four patients were identified, 70 males and 14 females, with a mean age of 22.5 years (range 8-71).Most accidents occurred during the summer months, most commonly in August.Each patient had an average of 1.6 injuries (n = 133) and these were divided into 15 categories, ranging from minor soft tissue to potentially life threatening.Operative intervention was indicated for 19 patients (23%) and several required multiple procedures.The commonest injuries were clavicle fractures (13%), shoulder injuries (12%), and distal radial fractures (11%).However, of a more sinister nature, one patient had a C2/3 dislocation requiring urgent stabilisation, one required a chest drain for a haemopneumothorax, and another required an emergency and life saving nephrectomy.Conclusion-This sport has recently experienced an explosion in popularity, and, as it carries a significant risk of potentially life threatening injury across all levels of participation, the use of protective equipment to reduce this significant morbidity may be advisable.
Additional voices heard in support of humane animal use in research
Authors: C. Marwick
Journal: JAMA (1990)

STUNG by the spreading incidence of vandalism of biomedical research laboratories in the name of more humane treatment of experimental animals, government leaders and scientists have joined the American Medical Association and others in the battle and are beginning to strike back. At the annual meeting of the Federation of American Societies for Experimental Biology, Louis W. Sullivan, MD, secretary of the US Department of Health and Human Services, called for legal action against those animal rights advocates who, by threats of intimidation and bombings, have "created a veritable siege mentality among research scientists." Later, the day before some animal rights activists were scheduled to stage a protest in connection with "World Animal Liberation Day" at the National Institutes of Health (NIH) in Bethesda, Md, Constance Horner, undersecretary of the US Department of Health and Human Services, also came out strongly in defense of the use of animals in scientific
AMA Awards Grants for Research on Smoking
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary complication of heroin intoxication. Aspiration pneumonia and diffuse bronchiectasis
Authors: M. L. Warnock
Journal: JAMA (1972)

An acute episode of heroin intoxication in a patient was complicated by aspiration of the gastric content and subsequent development of diffuse bronchiectasis. This clinical observation and certain experimental data in the literature suggest to us an etiologic role for aspiration in the development of necrotizing bronchitis and bronchiectasis and, perhaps, heroin pulmonary edema.