tbuckley/cabot-search huggingface dataset:
The Role of GH and IGF-I in Mediating Anabolic Effects of Testosterone on Androgen-Responsive Muscle
Authors: Carlo Serra, Shalender Bhasin, Frances Tangherlini, Elisabeth R. Barton, Michelle Ganno, Anqi Zhang, Janet Shansky, Herman H. Vandenburgh, Thomas G. Travison, Ravi Jasuja, Carl Morris
Journal: Endocrine Reviews (2010)

Testosterone (T) supplementation increases skeletal muscle mass, circulating GH, IGF-I, and im IGF-I expression, but the role of GH and IGF-I in mediating T’s effects on the skeletal muscle remains poorly understood. Here, we show that T administration increased body weight and the mass of the androgen-dependent levator ani muscle in hypophysectomized as well as castrated plus hypophysectomized adult male rats. T stimulated the proliferation of primary human skeletal muscle cells (hSKMCs) in vitro, an effect blocked by transfecting hSKMCs with small interference RNA targeting human IGF-I receptor (IGF-IR). In differentiation conditions, T promoted the fusion of hSKMCs into larger myotubes, an effect attenuated by small interference RNA targeting human IGF-IR. Notably, MKR mice, which express a dominant negative form of the IGF-IR in skeletal muscle fibers, treated with a GnRH antagonist (acyline) to suppress endogenous T, responded to T administration by an attenuated increase in the levator ani muscle mass. In conclusion, circulating GH and IGF-I are not essential for mediating T’s effects on an androgen-responsive skeletal muscle. IGF-I signaling plays an important role in mediating T’s effects on skeletal muscle progenitor cell growth and differentiation in vitro. However, IGF-IR signaling in skeletal muscle fibers does not appear to be obligatory for mediating the anabolic effects of T on the mass of androgen-responsive skeletal muscles in mice.
Neuroscience, AIDS head agenda at AMA-NY Hospital-Cornell conference
Authors: T. F. Kirn
Journal: JAMA (1987)

DURING THE PAST year, two topics have monopolized much of medicine's fair share of media attention. The United States is now more than 23 000 dead and six years into the acquired immunodeficiency syndrome (AIDS) epidemic. Efforts by scores of researchers are producing a more precise understanding of the disease, and a prodigious medical literature. Much of it was, and is, news. No surprise, then, that AIDS was a major topic of discussion at the American Medical Association's (AMA) Sixth Science Reporters Conference. Six of the eight presentations planned for the first day of the two-day conference held at and cosponsored by New York Hospital-Cornell Medical Center were about AIDS. Neurology and neuroscience were second. Those news stories told of promising drugs for Alzheimer's and Parkinson's diseases, adrenal glandbrain transplants, the possibility of fetal-brain-cell transplants, new theories of memory, and animal studies of spinaltissue regeneration. Fernando Nottebohm, PhD, and Ira
The decision to forgo CPR in the elderly patient
Authors: D. L. Schiedermayer
Journal: JAMA (1988)

CARDIOPULMONARY resuscitation (CPR) is attempted in one third of those who die in American hospitals. One third of these patients survive the initial resuscitation effort; one third of the survivors leave the hospital; 80% of these individuals will be alive six months later; and 60% will be alive five years later. Half of those who receive CPR are more than 65 years of age. The majority of the survivors remember nothing about the experience except a sore chest on awakening. Most long-term survivors resume their previous activity, but almost half decide to forgo CPR in the future and 2% of the survivors will be left in the persistent vegetative state.<sup>1-4</sup> As these data suggest, long-term survivors of cardiopulmonary arrest have run a daunting biologic gauntlet. Full recovery from cardiopulmonary arrest is a test of the responsiveness of the cardiopulmonary system, the tolerance of the brain to global ischemia, and
Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport
Authors: M Runnegar
Journal: Hepatology (1997)

To understand the regulation of receptor-mediated endocytosis in hepatocytes, we have used two specific inhibitors of serine-threonine protein phosphatases (PP), microcystin (MCYST) and okadaic acid (OKA) as probes to alter protein phosphorylation in hepatocytes. We have then examined the impact of these changes on the specific binding and uptake of transferrin (Tf) in hepatocytes. The measurement of PP activity in hepatocyte lysates showed that OKA and MCYST shared a common inhibition of protein phosphatase 2A (PP2A). Our results showed that both OKA (250 nmol/L) and MCYST (500 nmol/L) significantly reduced Tf uptake at steady state (P ≤ .05). The measurement of Tf internalization after 15 minutes in protein phosphatase inhibitor-pretreated cells revealed that the initial uptake was also significantly reduced. Binding studies showed that pretreatment with either of the phosphatase inhibitors did not result in significant changes in the Kd for Tf binding to transferrin receptor (TfR). Additionally, no significant changes in the number of TfR in the plasma membrane were observed in phosphatase inhibitor-pretreated cells. The treatment of hepatocytes with nocodazole (NOC), which results in microtubule disassembly and inhibition of microtubule-based vesicle transport, caused comparable reductions in initial and steady state levels of transferrin accumulation. The changes in transferrin accumulation by both phosphatase inhibitors and nocodazole were accompanied by redistribution of the microtubule-anchored Golgi apparatus and lysosomal network from the perinuclear region to the cell periphery. Our data show that the regulation of Tf uptake by receptor-mediated endocytosis is mediated by PP2A and additionally may occur through regulation of microtubule-based vesicle transport.
La sacro-coxalgie et son traitement.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic findings in Cowden syndrome
Authors: R. Coriat, M. Mozer, F. Caux, A. Chryssostalis, B. Terris, S. Grandjouan, R. Benamouzig, A. Martin, S. Chaussade
Journal: Endoscopy (2011)

Correction to: Endoscopic findings in Cowden syndromeEndoscopy 2011; 43(08): 723-726DOI: 10.1055/s-0030-1256342
Allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia or myelodysplastic syndromes: myth and reality
Authors: A. Sutra Del Galy, A. Marouf, E. Raffoux, M. Robin, D. Michonneau, M. Sébert, F. Sicre de Fontebrune, A. Xhaard, E. Lengline, R. Itzykson, C. Frieri, H. Dombret, P. Fenaux, R. Peffault de Latour, L. Adès, G. Socié
Journal: Leukemia (2020)
National Gay Men’s HIV/AIDS Awareness Day — September 27, 2018
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

National Gay Men's HIV/AIDS Awareness Day (https:// www.cdc.gov/features/ngmhaad/index.html) is observed on September 27, 2018, to direct attention to the ongoing and disproportionate impact of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) on gay, bisexual, and other men who have sex with men (MSM) in the United States.Whereas MSM represent approximately 2% of the U.S. population (1), in 2016 they accounted for 66.8% of new diagnoses of HIV infection; MSM who inject drugs account for an additional 3.0% (2).Among MSM with new diagnoses of HIV infection in 2016, 49.4% were aged 13-29 years, 38.2% were aged 30-49 years, and 12.4% were aged ≥50 years (3).During 2008-2016, the number of annual new diagnoses increased 3% per year among MSM aged 13-29 years, decreased 4% per year among MSM aged 30-49 years, and was stable among those aged ≥50 years.CDC supports a range of efforts to reduce HIV infection among MSM.These include HIV prevention services that increase diagnosis of HIV infection (https://www.cdc.gov/hiv/group/msm/index.html),support the linkage and engagement of MSM in care and treatment, and reduce the risk for acquiring and transmitting HIV infection (https://www.cdc.gov/msmhealth; https://www.cdc.gov/hiv/group/msm/bmsm.html).
Folic Acid Deficiency in Sickle Cell Anemia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abnormal cerebrovascular regulation in hypertensive patients.
Authors: D N Griffith, I M James, P A Newbury, M L Woollard
Journal: BMJ (1978)

into two parts-one was retained for bacteriological examination and the other dispatched frozen to the Torry Research Station at Aberdeen for chemical analysis.The total bacterial count was less than 500 organisms/g, consisting largely of coagulase-negative staphylococci.The Torry Research Station reported that the fish seemed in good condition but was very lightly cured (salt/wet weight 0-9 %, as opposed to the usual 3 %0 to 5 0%).The result of the mouse inoculation test for Clostridium botulinum was negative.The histamine content of the meat was 1480 mg/l (normal < 50 mg/l).
All-cause mortality and liver-related death following entecavir, tenofovir disoproxil fumarate or lamivudine therapy among treatment-naive chronic hepatitis B patients in British Columbia, Canada
Authors: Mawuena Binka, Younathan Abdia, James Wilton, Zahid Butt, Maryam Darvishian, Stanley Wong, Amanda Yu, Sofia Bartlett, Dahn Jeong, Emilia Clementi, Prince Adu, Dr. Margo Pearce, Maria Alvarez, Eric Yoshida, Alnoor Ramji, Dr. Jason Wong, Mel Krajden, Naveed Janjua
Journal: Journal of Hepatology (2020)
Hypoglycemia and body temperature
Authors: G. W. Molnar
Journal: JAMA (1974)

Among 36 recumbent nude men exposed for two hours in a thermoneutral environment, insulin-induced hypoglycemia reduced rectal and tympanic temperatures by 0 to 2 C (3.60 F). Twelve patients experienced rectal cooling below 36 C (96.2 F) (lowest, 34.9 C [94.8 F]); 17 experienced tympanic membrane cooling below this limit of normothermia. Cooling was due to reduction in heat production and to secretion of sweat, peripheral vasodilatation, and hyperventilation. Temperatures below 36 C (96.2 F) neither inhibited sweating nor stimulated shivering. Seven patients showed negligible cooling; they and three others did not sweat. Hypoglycemia was the same in those who cooled as in those who did not. Sweating and hyperventilation ceased while hypoglycemia persisted. Cooling may be greater during summer than during winter, perhaps because heatacclimatized sweat glands discharge more sweat. Published evidence establishes that hyperthermia occurs when hypoglycemia is complicated by infection, dehydration, or cerebral edema.
COLLOID MILIUM.
Authors: J. F. BECKER, HAROLD T. H. WILSON
Journal: British Journal of Dermatology (1956)

Journal Article COLLOID MILIUM. Get access J. F. BECKER, B.Sc., J. F. BECKER, B.Sc. Courtauld Institute of Biochemistry Search for other works by this author on: Oxford Academic Google Scholar HAROLD T. H. WILSON, M.D., M.R.C.P. HAROLD T. H. WILSON, M.D., M.R.C.P. Skin Department, Middlesex Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 68, Issue 11, 1 November 1956, Pages 345–349, https://doi.org/10.1111/j.1365-2133.1956.tb12764.x Published: 01 November 1956
The desperate case: CARE (costs, applicability, research, ethics)
Authors: F. D. Moore
Journal: JAMA (1989)

In this issue of The Journal two articles, one from Pittsburgh, Pa,<sup>1</sup>and one from Chicago, Ill,<sup>2</sup>report four clinical transplant experiences (two cases each) that involve the partial surgical evisceration of desperately ill children and the replacement of severely damaged vital abdominal organs from cadaver sources, under immunosuppressive chemotherapy. Further application of cadavaric transplant techniques to new vascularized organs is an inevitable extension of a series of operations—organ transplantations—formerly thought impossible. These organ transplantations commenced in the early 1950s, and with the addition of immunosuppressive chemotherapy in the early 1960s, they have now brought relief of suffering to hundreds of thousands of people over the world. The successful allotransplantation of vascularized vital organs under immunosuppressive chemotherapy must be regarded as one of the greatest advances in biomedical science in the second half of this century. In every instance, the extension of this method to organs beyond the
Section 41.—Familial Mediterranean Fever
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cigarettes.
Authors: E. W. Black
Journal: JAMA (1901)

Ft. Robinson, Neb., Nov. 9, 1901. <h3>To the Editor:</h3> —The statement that "cigarettes are the least dangerous form of tobacco," as quoted from Dr. Kuborn's Report to the Royal Medical Academy of Belgium, as noticed in the Paris Letter inThe Journalof October 12, seems to challenge justifiable inquiry. A very large percentage of the United States troops who have returned from Cuban service are addicted to this mode of tobacco-using, and—while the<i>modus operandi</i>of cigarette smokers may differ in different parts of the globe—the above mentioned quite generally inhale the smoke for several seconds, and then slowly expel it through the nostrils. By that time it seems to have parted almost entirely with the, at least grosser, products of combustion, as is apparent from its color, and as one might expect from its long and intimate contact with the moist surfaces of the lungs, bronchi, fauces, nares,
High frequency of theMAGE-1 gene expression in hepatocellular carcinoma
Authors: N Yamashita, H Ishibashi, K Hayashida, J Kudo, K Takenaka, K Itoh, Y Niho
Journal: Hepatology (1996)

The MAGE–1 gene, originally isolated from a human melanoma cell line, directs the expression of a potential tumor–rejection antigen, MZ2–E. This antigen is recognized by autologous cytotoxic T lymphocytes in association with a major histocompatibility complex class I molecule (HLA–A1), and has provided a basis for specific immunotherapy for melanoma patients. Here we show a high frequency of expression of the MAGE–1 gene in hepatocellular carcinoma (HCC). We examined the expression of the MAGE–1 gene in cell lines originated from hepatoma cells and in tumor and nontumor tissues of livers with HCC by reverse–transcription polymerase chain reaction (RT–PCR) and subsequent Southern blotting. MAGE–1 messenger RNA (mRNA) was expressed in three of four HCC cell lines (75%) and in 16 of 20 (80%) resected HCCs though none was detected in nontumor tissues. The high frequency expression of MAGE–1 gene in HCCs suggests the possibility as a target for tumor– specific immunotherapy for HCC patients.
Acoustically Handicapped Children. The Committee for the Study of the Care and Education of Physically Handicapped Children in the Public Schools of the City of New York. Report of the Sub-Committee on Acoustically Handicapped Children
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interplast. A successful model for anesthesia and plastic surgery in developing countries
Authors: S. I. Samuels
Journal: JAMA (1984)

MEDICINE has traditionally been described as a caring profession. It is in this caring tradition that teams of physicians travel from countries with highly sophisticated medical care systems to developing countries of the world to provide medical care for brief periods. Hospital facilities in the host countries are extremely variable, some being modern by Western standards and others much less so. In this article it is difficult to fully acknowledge the work of all those pioneering physicians who introduced simple effective anesthetic techniques for use in field conditions. The famous Epstein-Macintosh-Oxford (EMO) vaporizer was a direct result of Sir Robert Macintosh's perception that there was a need for a portable vaporizer in developing countries. With this in mind, the EMO and the Oxford miniature vaporizer (OMV) were designed.<sup>1,2</sup>On an equally practical level, the writings of Boulton and Cole<sup>3</sup>in the 1960s, as well as the more recent
Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
Authors: David H. Munn, Madhav D. Sharma, Deyan Hou, Babak Baban, Jeffrey R. Lee, Scott J. Antonia, Jane L. Messina, Phillip Chandler, Pandelakis A. Koni, Andrew L. Mellor
Journal: Journal of Clinical Investigation (2004)

During the preparation of this manuscript for publication, an error was introduced into the Results section, in the fourth sentence of the paragraph beginning with "The levels of the APP-derived soluble peptides Aβ40 and Aβ42 in brains of double-transgenic mice and APP [V717I] control animals at the age of 18 weeks were quantified by specific sandwich ELISAs."The correct sentence appears below.We regret this error.In line ADAM10-mo × APP [V717I] , Αβ40 and Aβ42 were reduced by 49% and 20%, and in line ADAM10-hi × APP [V717I] , by 39% and 29%, respectively.
Management of infectious waste by US hospitals
Authors: W. A. Rutala
Journal: JAMA (1989)

In July 1987 and January 1988, forty-six percent (441/955) of randomly selected US hospitals responded to a questionnaire intended to identify their waste disposal practices. Survey responses were received from hospitals in 48 states. United States hospitals generated a median of 6.93 kg of hospital waste per patient per day and infectious waste made up 15% of the total hospital waste. Most hospitals (&gt;90%) considered blood, microbiology, "sharps," communicable disease isolation, pathology, autopsy, and contaminated animal carcass waste as infectious. Other sources of hospital waste that were commonly (&gt;80%) designated infectious were surgical, dialysis, and miscellaneous laboratory waste. The infectious waste was normally (80%) treated via incineration or steam sterilization before disposal, whereas noninfectious waste was discarded directly in a sanitary landfill. Eighty-two percent of these US hospitals are discarding blood, microbiology, sharps, pathology, and contaminated animal carcass waste in accordance with the Centers for Disease Control's recommendations, while the compliance rate for the Environmental Protection Agency's recommendations (excluding optional waste) is 75%. No hospital could identify an infection problem (excluding needle-stick injuries) that was attributable to the disposal of infectious waste. While the management of infectious waste by US hospitals is generally consistent with the Centers for Disease Control's guidelines, many hospitals employ overly inclusive definitions of infectious waste. (<i>JAMA</i>. 1989;262:1635-1640)