tbuckley/cabot-search huggingface dataset:
Chlorinated Hydrocarbons in Women with Repeated Miscarriages
Authors: Ingrid Gerhard, Volker Daniel, Sonja Link, Bondo Monga, Benno Runnebaum
Journal: Environmental Health Perspectives (1998)

This study was conducted to investigate a possible etiological role of chlorinated hydrocarbons in the pathogenesis of repeated miscarriages. The blood levels of chlorinated hydrocarbons [CHCs: pentachlorophenol, hexachlorocyclohexane, hexachlorobenzene, the dichlorodiphenyltrichloroethane (DDT) group, polychlorinated biphenyls] were determined in 89 women with repeated miscarriages, who were referred to the University Hospital of Obstetrics and Gynecology of Heidelberg for investigations between 1989 and 1993, and compared to a previously investigated reference population. In more than 20% of the women, at least one of the CHC levels exceeded the reference range. CHC levels did not differ significantly between women with primary or secondary and early or late miscarriages; neither did they differ between women with hormonal or immunological disorders as causes of repeated miscarriages or women with idiopathic repeated miscarriages. No significant associations were detected between CHC levels and further conceptions or the outcome of further pregnancies. As significant associations were found between increasing CHC blood concentrations and immunological and hormonal changes, CHCs may have an impact on the pregnancy course in certain cases.
Cardiac toxicity of aerosol propellants
Authors: A. Silverglade
Journal: JAMA (1972)

No longer may the fluorocarbon propellants used in pressurized bronchodilator aerosols be considered "inert"; nor should they be judged unsafe and a contributing cause of death in asthmatic patients. The facts are clearly established in the coniderable research of the past two years. These halogenated hydrocarbon propellants, sometimes called fluoroalkane or haloalkane gases, bear a number of trade names, the more common being Freon in the United States and Arcton in England. The various fluorocarbon compounds are designated by numbers. The propellants used in the bronchodilator aerosols in the United States include fluorocarbons 11, 12, and 114. Fluorocarbon will be represented here by the letter F. That exposure to fluorocarbon compounds in high concentration for five minutes was capable of sensitizing the hearts of conscious dogs to large intravenously given doses of epinephrine, resulting in serious cardiac arrhythmias, was first demonstrated by Reinhardt and associates<sup>1</sup>and was confirmed in
This Month's Highlights
Journal: Journal of the American Society of Nephrology (2007)

### MDCK Cells, CsA, and TGF-β. MDCK cells have characteristics of distal tubules with relatively high transepithelial resistance (TER), a measure of the integrity of the epithelial barrier in this system. Cyclosporine A (CsA) increases TER in MDCK cells through extracellular signal–regulated
Leads from the MMWR. Rubella vaccination during pregnancy--United States, 1971-1982
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Online Referrals
Authors: Rebecca Voelker
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phoenix- A humanised <sup>90</sup>Y-conjugated monoclonal antibody for the treatment of relapsed breast cancer
Authors: A. A. Epenetos, R. Ceriani, J. Peterson, P. Cagnoni, Y. Nieto, R. Jones
Journal: Journal of Clinical Oncology (2004)

632 Background: Phoenix is a 90Y-conjugated humanised IgG1 monoclonal antibody directed against a tandem repeat of deglycosylated mucin expressed in >90% of breast carcinomas. Methods: Following an imaging and pharmacokinetic study demonstrating successful targetting of approximately 80% of breast cancer lesions, a phase I-II study was conducted in 17 patients with relapsed breast cancer refractory to any available treatment. Results: Out of 17 patients treated, 8 patients had an objective response, 9 patients did not respond and 1 patient was not evaluable. Statistical analysis indicates that the difference between the responders and the non-responders for time to relapse is significant (p>0.02). Conclusions: Phoenix appears to be an active agent in relapsed breast cancer. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Somantis Limited Somantis Limited
Can the Practice of Retainer Medicine Improve Primary Care?
Authors: Marcy Zwelling
Journal: Annals of Internal Medicine (2012)

Letters6 March 2012Can the Practice of Retainer Medicine Improve Primary Care?Marcy Zwelling, MDMarcy Zwelling, MDFrom Choice Care, Los Alamitos, CA 90720.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-5-201203060-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their article, Huddle and Centor (1) present a very thoughtful exposition of the social obligations of primary care physicians and their understanding of the ethical commitment those of us practicing retainer medicine have toward our patients. I would like to offer some additional thoughts.I decided to leave traditional medicine because I had a visceral need to do my job, and I could not be the professional my patients deserved if I spent 9 to 15 minutes with them per visit. I found it disquieting to charge a patient to sit in my waiting room for ...Reference1. Huddle TS, Centor RM. Retainer medicine: an ethically legitimate form of practice that can improve primary care. Ann Intern Med. 2011;155:633-5. [PMID: 22041952] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Choice Care, Los Alamitos, CA 90720.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRetainer Medicine: An Ethically Legitimate Form of Practice That Can Improve Primary Care Thomas S. Huddle and Robert M. Centor Can the Practice of Retainer Medicine Improve Primary Care? Josh J. Umbehr Can the Practice of Retainer Medicine Improve Primary Care? Douglas M. Van Zoeren Can the Practice of Retainer Medicine Improve Primary Care? James Webster Can the Practice of Retainer Medicine Improve Primary Care? Martin T. Donohoe Can the Practice of Retainer Medicine Improve Primary Care? Thomas S. Huddle and Robert M. Centor Metrics 6 March 2012Volume 156, Issue 5Page: 399KeywordsConflicts of interestHealth carePatient advocacyTraditional medicine ePublished: 6 March 2012 Issue Published: 6 March 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
"Cipromania" and "Superclean" Homes Are Now Increasing Antibiotic Resistance
Authors: B. Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OS07.4 Efficacy of a novel antibody-drug conjugate (ADC), ABT-414, as monotherapy in epidermal growth factor receptor (EGFR) amplified (EGFRamp), recurrent glioblastoma (rGBM)
Authors: M. van den Bent, H. Gan, A. Lassman, P. Kumthekar, N. Butowski, L. Nabors, J. Simes, D. Maag, D. Reardon
Journal: Neuro-Oncology (2017)

Background: Patients (pts) with rGBM have a poor prognosis. EGFRamp is present in ~50% of GBMs. ABT-414 is an ADC that releases a potent toxin, monomethyl auristatin F (MMAF), inside cells with EGFRamp. Here we report the safety and efficacy of ABT-414 monotherapy at the recommended phase 2 dose (RPTD) in EGFRamp, rGBM. Methods: M12-356 (NCT01800695) is an open-label, Phase 1 study with three escalation cohorts. Study design and RPTD was reported previously (ASCO Meeting 2015, SNO Meeting 2015). Sixty pts, all with EGFRamp, rGBM, were enrolled as part of the escalation (12 pts) or expansion (48 pts) cohort treated with ABT-414 monotherapy at 1.25 mg/kg. Adults with measurable (RANO), bevacizumab-naïve, rGBMs with EGFRamp confirmed centrally were eligible. Results: As of March 1, 2016, 60 pts with EGFRamp, rGBM underwent treatment. Median age was 58 years (range, 35–80). Pts underwent 1, 2 (43% each) or 3 (13%) prior therapies. The most common treatment emergent adverse events (TEAEs) (≥20% pts) included blurred vision (65%), headache, fatigue (30% each), eye pain and photophobia (28% each). Grade 3/4 TEAEs (>1 pt) were keratitis (13%), corneal epithelial microcysts (8%), blurred vision (5%), dry eye, ulcerative keratitis and reduced visual acuity (3% each). The best RANO responses of 56 pts with complete data were: 3 (5%) partial responses, 24 (43%) stable diseases and 29 (52%) progressive diseases. Median duration of overall response in 3 patients with partial responses was 4.4 months (range, 1.9–5.6). The 6-month progression-free survival (PFS6) estimate was 25.3% [95% CI=14.8, 37.2]. Conclusions: ABT-414 monotherapy displayed frequent but mostly grade 1/2 ocular toxicities. An encouraging PFS6 (25%) was observed in this rGBM population where 56% had ≥2 prior therapies. A global randomized trial of ABT-414, alone or with TMZ, vs. TMZ or lomustine, is underway in EGFRamp, rGBM (NCT02343406).
Extramedullary hematopoiesis in the adult mouse liver is associated with specific hepatic sinusoidal endothelial cells
Authors: J Cardier
Journal: Hepatology (1997)

In previous work, two anatomically distinct-liver sinusoid endothelial cells (LEC): LEC-1 and LEC-2, have been described. We also reported that extramedullary hepatic hematopoiesis occurs only in close contact with LEC-1, suggesting that these cells may provide the microenvironment necessary for the maintenance and growth of hematopoietic cells. In the present work, we studied the capacity of LEC-1 and LEC-2 to maintain in vitro hematopoiesis. LEC-1 and LEC-2 were isolated and cloned from livers of adult mice. Bone marrow cells (BM) enriched with primitive hematopoietic progenitors were isolated from day-2, post-5-FU-treated mice (5-FUBMC). LEC-1 supported the maintenance and differentiation of hematopoietic progenitors for more than 6 weeks in vitro. In contrast, LEC-2 cells poorly supported the proliferation of hematopoietic cells for only two weeks of the co- culture. LEC-1 and 5-FUBMC cocultures showed cobblestone-area formation and the presence of hematopoietic progenitors that are able to form colonies (CFC) in the adhering fraction after six weeks of coculture. LEC-1 co-cultures treated with a cocktail of cytokines (stem cell factor, interleukin [IL]1α, IL-3, and Epo) showed that megakaryocyte (CFU-Mk) and erythrocyte progenitors (BFU-e) were present during the entire period of the culture. Granulocyte-macrophage progenitors (CFU-GM) were present only during the first three weeks of the culture. These results suggest that LEC-1, but not LEC-2, provide an appropriate hematopoietic microenvironment for supporting the proliferation and differentiation of primitive hematopoietic cells. This could explain the anatomical restriction of hematopoietic cells for growing in LEC-1 domains during liver extramedullary hematopoiesis.
Captopril and digoxin in mild to moderate heart failure
Authors: J. Zatuchni
Journal: JAMA (1988)

<h3>To the Editor.</h3> —Enalapril, an angiotensin converting-enzyme inhibitor, is known to be beneficial in the treatment of severe heart failure.<sup>1</sup>Now, the Captopril-Digoxin Multicenter Research Group reports that another angiotensin converting-enzyme inhibitor, captopril, is better than digoxin, which, in turn, is no better than placebo in the treatment of patients in sinus rhythm with mild to moderate heart failure.<sup>2</sup>Yet, the conclusions of the study depend on a precision that is lacking in the methods employed, principally, the treadmill exercise test and functional classification by the New York Heart Association. Dyspnea and fatigue are subjective end points of a treadmill exercise test that can be influenced not only by the patient but perhaps more importantly by the physician who is monitoring the test. The latter can shorten or lengthen the exercise time by whim or will, and the difference may exceed that of the advantage of 1½ minutes
Editorial: Non-union of the scaphoid.
Journal: BMJ (1974)

specific indicator of epithelial cell damage but may enhance the diarrhoea, which may be particularly important in children, who tolerate lactase deficiency badly.Thirdly, the effects of a virus on intestinal function can be measured.Absorption of xylose, fat, and lactose may be decreased during the acute phase of the disease and may be prolonged well into the con- valescent stage.Occasionally standard absorption tests are depressed in the absence of clinical illness.4Xylose absorption tests could theoretically be abnormal as a result of gastric stasis, which may be profound, but absorption has been shown to be impaired even after intraduodenal administration of the sugar.' 9 Finally, faecal leucocyte excretion is not increased in viral enteritis, which is a simple way of distinguishing it from diarrhoea due to bacterial infection or ulcerative colitis.4 22 Possibly jejunal biopsy and simple absorption tests are better markers of the presence of disease than are clinical symptoms.However, a comparison of these methods with screening for faecal virus particles will be interesting.For the moment, the general practitioner can be reassured that a disease which he regularly diagnoses actually exists.
Effect of Asbestos on the P388D1 Macrophagelike Cell Line: Preliminary Ultrastructural Observations
Authors: Neil F. Johnson, Reginald Davies
Journal: Environmental Health Perspectives (1983)

The ultrastructural effects of mineral dusts on a macrophagelike cell line (P388D1) were studied by transmission electron microscopy. The cells were found to contain virus particles which probably did not exert a cytopathic effect toward the cells. During mitosis the asbestos fibers appeared to be pushed to the periphery of the cell. The distribution of the asbestos in the P388D1 cells was similar to that seen previously in cultured peritoneal macrophages, and it was concluded that the cytotoxic effect of asbestos towards the cells was due to mechanical effects, e.g., by penetrating structures such as the nucleus or phagosomes, by preventing the ordered movement of organelles with the cell or by disrupting the cytoskeletal framework of the cell.
Editorial: Follow-up of coronary disease.
Journal: BMJ (1973)

screen all these women for the serum lipid abnormalities.But if a woman is known to be hyperlipaemic or has a relevant family history, and a combined form of oral contraceptive is to be :sed, at least the serum should be examined for opalescence, and if possible, serum lipids should be measured before and periodically during therapy.But the occurrence of bouts of abdominal pain should bring to mind this association of hyperlipaeinia and pancreatitis.
Mitral insufficiency in Marfan's syndrome: surgical correction
Authors: J. C. Kiser
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Technology, funds promise new era in parasitology
Authors: P. Gunby
Journal: JAMA (1984)

If the projected 8.3 billion people are on earth to welcome the year 2025, there is a reasonable likelihood—if conditions are not altered in the meantime— that more than half of them will be infected with parasitic diseases. However, there now are indications that steps (by the World Health Organization and others) may be taken during the rest of the 1980s and the remaining years of this century to change that gloomy possibility, as well as to give new emphasis and scope to parasitology research. The most dramatic development has come in recent days in the form of an announcement from the John D. and Catherine T. MacArthur Foundation that it will fund "a research consortium dedicated to discovering new means of controlling parasitic illnesses such as malaria, tape-worm, dysentery, and African sleeping sickness." These and other parasitic illnesses are being called "the most costly and debilitating diseases in the
Augmentation of portal blood flow improves function of human cirrhotic liver
Authors: J Cardoso
Journal: Hepatology (1994)

In cirrhotic livers, the intrahepatic resistance is increased and drug elimination and portal transhepatic flow are decreased. The aim of our work was to study the effect of a twofold increase in portal blood flow during 2 hr on the hemodynamic parameters, drug elimination and hepatic viability in eight isolated perfused human cirrhotic livers. Using an oxygenated recirculating system with independent arterial and portal flows, we perfused livers with Kreb's buffer bicarbonate solution, bovine serum albumin (20 gm·L−1) and human red blood cells (hematocrit 20). The flow was maintained at a basal level of 0.713 ± 0.19 L/min for 1 hr and then increased and maintained for 2 hr at twice the basal flow. Portal pressure-portal flow curve slopes were linear (27.04 ± 21.06 mm Hg·L−1·min; range = 6.43 to 60.8) and correlated with intrahepatic resistance during the basal-flow period (r = 0.87, p < 0.01). Parameters registered during the basal- and high-flow periods were compared by use of Student's t test: portal pressure increased from 23.5 ± 7 to 37.3 ± 16.7 mm Hg (p < 0.05); arterial pressure increased from 80.3 ± 19 to 103.5 ± 26 mm Hg (p < 0.005); hepatic artery flow resistance increased 31.9 (from 690.1 ± 218 to 899.4 ± 269 mm Hg·L−1·min; p < 0.005); indocyanine green clearance increased by 28.2 (from 86.0 ± 58.3 to 109.2 ± 74.8 ml·min−1·kg liver−1; p < 0.04). No significant differences were observed in enzyme release, biliary flow (n = 5) and oxygen consumption. Histological examinations demonstrated sinusoidal dilatations in six of eight cases. These results suggest that better liver perfusion and function of cirrhotic nodules might be obtained by increasing portal flow and perfusion pressure. (Hepatology 1994;19:375–380).
The Metabolic Basis of Inherited Disease
Authors: John T. Garland
Journal: JAMA (1983)

The appearance of a fifth edition illustrates the marketability of<i>any</i>book. Surely, the publisher would have tired of the effort if there were no interest. This opus required two new editors—in addition to the three senior editors who have labored over all five editions—to coordinate the efforts of 138 contributors who produced 91 chapters. One should not purchase such an expensive tome simply for the weight of authority (approximately 6 lb), but there are many other reasons to recommend this book. Despite the plethora of contributors, they maintain an exceptionally high standard of terse exposition. The clear layout, legible type, and judicious use of superb line drawings and summary tables unify the diverse styles. The introductory comments and summaries serve well to orient the nonspecialist to each chapter. The index and the generous use of apt subheadings facilitate efficient excursions into the text for answers to specific questions. Those
La coloscopie de surveillance en Autriche: les recommandations sont-elles suivies?
Journal: Endoscopy (2018)

Les objectifs de cette étude étaient d’évaluer si les gastroentérologues participants au projet national de certification qualité pour la coloscopie de dépistage en Autriche suivaient les recommandations européennes de surveillance post-polypectomie éditées en 2010 dans le cadre du dépistage du cancer colorectal et si une simple lettre de rappel soulignant l’importance d’un intervalle de surveillance approprié, incluant la traduction allemande des recommandations européennes, permettait une meilleure adhésion aux guidelines.