tbuckley/cabot-search huggingface dataset:
Desert Storm data compilation continues
Authors: P. Gunby
Journal: JAMA (1991)

AEROMEDICAL EVACUATION associated with the Desert Storm operation is winding down. But preliminary figures indicate that about 43% of the US military personnel who were injured during the war were assigned to the medical evacuation flights because of orthopedic injuries. Monte B. Miller, MD, the three-star officer who is retiring shortly as surgeon general of the US Air Force, says that other percentages from these preliminary data on diagnoses of patients flown out of the theater of operations include 9% respiratory, 8% neurological or neurosurgical, 6% otorhinolaryngologic, 6% internal medicine, 5% general surgical, and 23% other (allergic, psychiatric, obstetric, gynecologic, or other categories). The Air Force called (to full-time active duty) 725 physicians from the various states' Air National Guard units or from the Air Force Reserve, Miller says. About half of these activated physicians served in Europe or with the Desert Shield/Storm forces and the rest replaced full-time Air
Increased Survival from Cardiac Arrest Since the Introduction of External Massage
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decreased right heart blood volume determined by magnetic resonance imaging: evidence of central underfilling in cirrhosis*1
Authors: S MOLLER
Journal: Hepatology (1995)

Whether the central blood volume is reduced or expanded in cirrhosis is still under debate. Accordingly, the current study was undertaken to assess the volume of the heart cavities. Ten cirrhotic patients and matched controls had their right and left ventricular end-diastolic volumes (RVDV and LVDV), and end-systolic volumes (RVSV and LVSV) determined by magnetic resonance imaging (MRI). RVDV (122 vs. control 166 mL, P < .02), RVSV (41 vs. 80 mL, P < .02) and right atrial volume (47 vs. 64 mL, P < .05) were significantly reduced in the patients. In contrast, LVDV (134 vs. 129 mL, NS), LVSV (54 vs. 40 mL, NS), and left atrial volume (70 vs. 57 mL, P = .08) were normal or slightly increased. The right ejection fraction (68% vs. 53%, P < .05) was significantly increased, but the left ejection fraction was slightly reduced (61% vs. 69%, NS). The central and arterial blood volume (CBV), assessed as the cardiac output (CO) multiplied by the central circulation time, was significantly decreased (1.47 vs. 1.81 L, P < .05). The noncentral blood volume (4.43 vs. 3.64 L, P < .02), plasma volume (4.05 vs. 3.27 L, P < .02), and CO (7.11 vs. control 5.22 L/ min, P < .01) were significantly increased in the patients. CCT (13.1 vs. 20.0 sec, P < .005) and the right ventricular transit time (0.79 vs. 1.35 sec, P < .005) were significantly reduced, but the left ventricular transit time was normal (0.91 vs. 0.88 sec, NS). Systemic vascular resistance was reduced (991 vs. 1,490 dyn-sec/cm5, P < .01). Our results are in keeping with a hyperkinetic circulation in cirrhotic patients with central vascular underfilling with reduced right heart blood volume and central and arterial blood volume. The normal or slightly increased left heart blood volume suggests a complex pattern with a relatively decreased left ventricular function. The results support the concept of an abnormal distribution of the blood volume, with central and arterial underfilling (consequent on the combination of decreased systemic vascular resistance and left ventricular dysfunction) as major elements in the abnormal fluid homeostasis in cirrhosis.
Rum fits and DT's
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endocrinology
Authors: R. L. Young
Journal: JAMA (1980)

Among the many advances in endocrinology in the past decade, three have been singled out for discussion: the discovery of cellular receptors, the concept that diabetes is more than one disease, and the newer aspects of pituitary therapy with emphasis on hyperprolactinemic states. Advances in these areas have profoundly altered our current concepts and treatment of disease. <h3>Discovery of Cell Receptors</h3> The identification of cell receptors has been central in increasing our understanding of familial hypercholesterolemia. One form of this disorder seems to result from a defect in low-density lipoprotein (LDL)-cholesterol receptors, which in turn diminishes the cell's ability to internalize cholesterol.<sup>1</sup>Since intracellular LDL-cholesterol concentration regulates the feedback suppression of endogenous cholesterol synthesis, this inability to internalize LDL results in unabated production of cholesterol by the cells. It has been estimated that the heterozygous form of familial hypercholesterolemia occurs in one of every 500 people in the general population.
Acute Respiratory Illness Linked to Use of Aerosol Leather Conditioner—Oregon, 1992
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reference Committees 1987 Interim Meeting
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
With GBM, T Cells May Be Stuck in Bone Marrow
Journal: Cancer Discovery (2018)

A recent study uncovered a possible explanation for why patients with glioblastoma often have low levels of circulating T cells: The cells become sequestered in the bone marrow in high numbers, and are likely unable to leave because they lack the S1P1 receptor. The findings could lead to the development of more-effective immunotherapies.
The Standard English of Medical Men.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Gonorrhoea of the pharynx.
Journal: BMJ (1974)

to which the answers would be largely philosophical.If it is effective when applied to some for short spells it could presumably be much more effective if applied to all for long periods or continuously.That would put decompression in a similar category to the possibility of enhancing cerebral acuity and diminishing risk of infection by living continuously in a sterile chamber of hyperbaric oxygen-scientifically possible but on a commonsense basis nonsensical.For most obstetricians and their patients nature's abhorrence of a vacuum seems likely to prevail.
USE AND ABUSE OF MILK IN DIET OF CHILDREN
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plastic Surgery
Authors: Elvin G. Zook
Journal: JAMA (1994)

A more complete understanding of the nature of wound healing is bringing change and great optimism to the specialty of plastic surgery. Efforts to gain greater control of the body's reparative process continue. Potential clinical applications for growth factors—most notably platelet-derived growth factor (PDGF) and transforming growth factor β (TGF-β)—include accelerating surgical incision healing, managing decubiti and other nonhealing wounds, and inhibiting scar formation. Animal studies and early clinical trials have shown that growth factors can be powerful agents in manipulating wound repair. In a preliminary safety trial that measured the effects of topical PDGF on decubiti, accelerated wound healing was noted in five of the 23 patients who received the growth factor.<sup>1</sup>Healing was accelerated by an estimated 10 days in the treatment group. Similar encouraging results were seen in a multicenter, prospective, randomized trial that involved elderly nursing home residents. Although no improvement was demonstrated in the
Multimodal Influence of Estrogen upon Gonadotropin-Releasing Hormone Neurons
Authors: A. E. Herbison
Journal: Endocrine Reviews (1998)

I. Introduction II.Effects of Estrogen on GnRH Neurons A. Sexual differentiation B. Biosynthesis of GnRH C. Biosynthesis of galanin D. Electrical activity of GnRH neurons E. GnRH secretion F. GnRH degradation G. Ultrastructural changes involving GnRH neurons H. Summary of estrogen's influence on GnRH cells III.Brain Sites of Estrogen Influence on GnRH Neurons A. Sites of estrogen's stimulatory sites B. Sites of estrogen's inhibitory action C. Summary IV
Use of the scintillation anger camera and xenon Xe 133 in the study of chronic obstructive lung disease
Authors: J. R. Medina
Journal: JAMA (1969)

Pulmonary ventilation and perfusion were studied in 12 normal subjects and 40 patients with obstructive lung disease. Xenon Xe 133 and the scintillation Anger camera were used. Serial photographs were obtained after injection, inhalation, and washout of xenon Xe 133. The distribution of blood flow and ventilation was studied in these photographs. Normal subjects presented uniform distribution of perfusion and ventilation. Preferential blood flow to the bases was noted because the patients were in the upright position. Patients with severe, chronic, obstructive lung disease showed regions of poor ventilation with or without areas of impaired perfusion. The scintiphotographs were found to be a valuable addition to the study of regional lung function, since they permit identification and mapping of areas of impaired perfusion or of poor ventilation.
Predicting the likelihood of an isocitrate dehydrogenase 1 or 2 mutation in diagnoses of infiltrative glioma
Authors: C. Horbinski
Journal: Neuro-Oncology (2015)

constrained that the cost of sequencing outweighs the benefit provided by the information gained from accurate IDH mutation testing.Similarly, in a research setting, it is highly unlikely that any researcher would base the decision to immunostain or sequence the sample on what the model predicts.In conclusion, we suggest that the models proposed by Chen et al demonstrating the clinical and pathological factors, which can be important for predicting IDH1/2 mutation in diffuse gliomas, currently have limited utility in both the clinical and research settings.
The risk of cervical cancer in teen-aged girls
Authors: W. M. Christopherson
Journal: JAMA (1965)

CONSIDERABLE INTEREST was aroused by Ferguson's report, in the latter part of 1961, of an extraordinary large number of "positive cancer smears in teen-age girls."<sup>1</sup>The author pointed out that a cervical cell study should be included in their pelvic examination. However, our data on the prevalence of "positive cancer smears" in teen-aged girls differ so extremely from Ferguson's report, that I thought it important to record this conflicting experience, and place the relative risk in its proper perspective. <h3>Material</h3> We have performed cervical cell studies on 5,061 girls 19 years of age or less. Many have been studied at yearly intervals. Of these patients, 86% were medically indigent. The remainder worked in industry (290), or were private patients (438). (We have previously reported on the prevalence of cervical cancer in this low-income group as a whole.<sup>2</sup>) The vast majority of cells studied were obtained from patients in
Clostridial spontaneous peritonitis
Authors: R. L. Brown
Journal: JAMA (1976)

THE SYNDROME of spontaneous peritonitis and bacteremia is a welldocumented complication in cirrhotic patients with ascites.<sup>1</sup><i>Escherichia coli</i>, other enteric Gram-negative rods, and<i>Streptococcus pneumoniae</i>account for most reported cases, while anaerobic bacteria are rare.<sup>1,2</sup>Clostridia bacteremia has been noted in chronic alcoholics,<sup>3</sup>but, to our knowledge, has not been previously associated with spontaneous peritonitis. <h3>Report of a Case</h3> A 54-year-old chronically alcoholic woman with biopsy-proved Laënnec cirrhosis, ascites, and esophageal varices demonstrated by prior esophagoscopy was admitted to the Rhode Island Hospital with hematemesis and melena of two days' duration. She did not have any other abdominal symptoms, fever, or chills. Significant past history included insulin-dependent diabetes mellitus. The patient was alert, in no acute distress, pale, and had a temperature of 38.8 C. The abdomen was distended with obvious ascites, but was nontender. Laboratory values included the following: hemoglobin, 6.7 gm/100 ml; leukocyte count, 13,400
THE CONTROL OF MALARIA.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brain Death
Authors: William H. Sweet
Journal: New England Journal of Medicine (1978)

The inescapable logic of the concept that death of the brain is equivalent to death of the person has now achieved widespread acceptance. In the decade since a Harvard Ad Hoc Committee enunciated the view and gave specific guidelines for making such a diagnosis,1 a vast literature has developed on this subject. The Medical Progress article by Dr. Peter Black appearing in the last two issues of the Journal is a superb summary of various facets of the subject ranging through medicine, law, ethics and public opinion. The title of the Harvard report was: "A Definition of Irreversible Coma: Report . . .
Severe bleeding disorders in children with normal coagulation screening tests.
Authors: Hermon Dowling, David Ruyppin
Journal: BMJ (1982)

treatment it could mean that the patient was receiving months of unnecessary, ineffective, and expensive treatment.Ultrasound is likely to prove useful in detecting spontaneous gall-stone recurrence and in monitor- ing the efficacy of postdissolution treatments given in attempts to prevent recurrence.If recurrent stones are detected, however, and treatment options include the possibility of further dissolution therapy, supplementary oral cholecystography will again be necessary.In our present state of ignorance, we agree that it seems sensible to use both cholecysto- graphy and ultrasonography of the gall bladder in monitoring the response to medical treatment and in the follow-up of patients after "confirmed" complete gall-stone dissolution.Indeed, this has been our policy since reliable ultrasonography first became available at Guy's Hospital.The routine use of both techniques is also part of the protocol of the British National Gall-stone Group in their multicentre, postdissolution trial.But to return to Dr Somerville and colleagues' title question: are we being misled?We do not think so, but we do not know and until the incidence of false-positive and false-negative results with both imaging techniques be- comes established, we believe that we should keep an open mind and avoid dogma.
How to evaluate a diagnostic marker test. Lessons from the rise and fall of dexamethasone suppression test
Authors: A. A. Nierenberg
Journal: JAMA (1988)

To understand why the dexamethasone suppression test (DST) for the diagnosis of depression became widely accepted and later rejected, we reviewed the sequence of publications in the DST literature. To evaluate the events, we developed and applied concepts of a five-phase process that can be used to assess the clinical utility of diagnostic marker tests. The review showed that when the DST was introduced into the clinical arena, the initial and final two phases of testing (I, IV, and V) had not been adequately conducted. When these phases of testing were suitably checked many years later, the Phase I studies (exploring basic mechanics of test procedures) showed that dexamethasone had variable bioavailability and that the cortisol assay procedure was unreliable. The Phase IV and V studies (examining test results in groups with suitably broad spectrums of cases and controls) showed that the test did not differentiate depression from most pertinent comorbid conditions. Beyond application to the specific problems of the DST, the proposed five phases of development and evaluation for diagnostic marker tests can be used to plan suitable research and avoid similar problems in the future. (<i>JAMA</i>1988;259:1699-1702)