tbuckley/cabot-search huggingface dataset:
Salicylamide sulfate cell entry in perfused rat liver: A multiple-indicator dilution study
Authors: X Xu
Journal: Hepatology (1994)

The hepatocellular entry of salicylamide sulfate conjugate, which binds to both red blood cells and albumin, was examined with the multiple-indicator dilution technique in the perfused rat liver, with medium containing both 20 red cells and 1 albumin (set A), red cells only (set B), albumin only (set C) and neither red cells nor albumin (set D). [14C]Salicylamide sulfate, 51Cr-labeled red cells (a vascular reference), 125I-labeled albumin, [3H]sucrose or [58Co] ethylenediaminetetraacetic acid (EDTA) (high and low molecular weight interstitial references, respectively) and 3H2O or D2O (a cellular reference) were injected as a bolus into the portal vein. Among all sets of outflow data, the earliest immediate vascular recoveries for the [14C] salicylamide sulfate were lower than those for the vascular reference. For sets A and B, the upslopes precessed those for the 58Co-EDTA curve, then crossed over the 58Co-EDTA curves, with lower magnitude peaks occurring at the same time as those for labeled albumin, whereas for sets C and D, in which red cells were absent, the upslopes of [14C]salicylamide sulfate lagged behind those for labeled albumin and [3H]sucrose, reaching lower magnitude peaks coincidental in time with those for labeled sucrose. The precession of the [14C]salicylamide sulfate curve over 58Co-EDTA or [3H]sucrose in the presence (sets A and B) but not in the absence (sets C and D) of red cells and the absence of precession with albumin alone (set C) suggest that a red cell effect on the upslope is more evident than that for albumin. For all experiments, the downslopes of the sulfate curve crossed over those of the labeled red cells, albumin, 58Co-EDTA and sucrose curves and then the water curve at around the peak. The downslopes of the [14C]salicylamide sulfate were similar to those for labeled water, suggesting rapid cellular influx and efflux of salicylamide sulfate. Quantitative evaluation with a barrier-limited space-variable transit-time model for rapidly equilibrating red cell and albumin binding accounted for the upslope effects on [14C]salicylamide sulfate behavior and demonstrated its relatively high liver cell permeability. Values for the unbound permeability surface area product (0.029 to 0.036 ml sec−1·gm−1) were not different, regardless of the presence or absence of red cells and albumin, and slightly exceeded values for hepatic blood flow (0.0186 ± 0.0016 ml sec−1·gm−1). Comparable influx (0.083 to 0.14 sec−1) and efflux (0.10 to 0.18 sec−1) coefficients were obtained, suggesting rapid cellular entry and efflux of salicylamide sulfate. The ratio of the derived rate constants, which corresponds to the concentration ratio across the membrane, was 0.40 to 0.55. The findings contrast sharply with those for acetaminophen sulfate, which enters liver cells poorly. (Hepatology 1994; 19:229–244).
Analyzing Residual Disease in Triple-Negative Breast Cancer
Journal: Cancer Discovery (2012)

Abstract Next-generation sequencing of 81 triple-negative breast cancer residual-disease tumors has shown that about 90% had an aberration in at least one gene targeted by PI3K/mTOR inhibitors, DNA-repair targeting agents, RAF/MEK inhibitors, cell-cycle inhibitors, or growth factor receptor tyrosine kinase inhibitors.
<i>Manual of Psychiatry</i>. By J. Rogues de Fursac, M. D., FormerlyChief of Clinic at The Medical Faculty of Paris, Physician-in-Chief of the Public Insane Asylums of the Seine Department, and A. J. Rosanoff, M. D., First Assistant Physician, Kings Park State Hospital, N. Y. Fourth Edition. Revised and Enlarged. (<i>New York: John Wiley &amp; Sons, Inc. London: Chapman &amp; Hall, 1916</i>.)
Journal: American Journal of Psychiatry (1917)
Study of the Combined Action of a Group of Chlorine Derivatives of Hydrocarbons Entering the Organism by Inhalation
Authors: G. I. Sidorenko, V. R. Tsulaya, T. I. Bonashevskaya, V. M. Shaipak
Journal: Environmental Health Perspectives (1979)

The combined action of substances having a munidirectional toxic effect on the organism was studied for several typical chlorine derivatives of hydrocarbons (1,2-dichloropropane, 1,2,3,-trichloropropane, and perchloroethylene). Since a correct assessment of the combined action of substances is based on the comparison of the effect of mixed compounds and the effects observed for each component alone, research was conducted on each individual substances on the basis of the "concentration--time" relationship. The reaction of several mixtures of substances was also studied at various concentration levels, from high to low concentration levels of substances which are actually present in the atmosphere. Research result showed that the character of the mixture at both high and low levels of concentration was identical and approximate to the overall effects.
Q Fever— California, Georgia, Pennsylvania, and Tennessee, 2000-2001
Journal: JAMA (2002)

Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. The most common reservoirs are domesticated ruminants, primarily cattle, sheep, and goats. Humans acquire Q fever typically by inhaling aerosols or contaminated dusts derived from infected animals or animal products. Its highly infectious nature and aerosol route of transmission make C. burnetii a possible agent of bioterrorism. Although up to 60% of initial infections are asymptomatic, acute disease can manifest as a relatively mild, self-limited febrile illness, or more moderately severe disease characterized by hepatitis or pneumonia. It manifests less commonly as myocarditis, pericarditis, and meningoencephalitis. Chronic Q fever occurs in <1% of infected patients, months or years after initial infection. Chronic disease manifests most commonly as a culture-negative endocarditis in patients with valvular heart disease. During 2000-2001, a total of 48 patients who met the case definition of Q fever were reported to CDC. This report describes the case investigations for six of these patients, which indicate that these persons acquired Q fever probably through direct or indirect contact with livestock. To enhance surveillance efforts, health-care providers should report cases of Q fever to state health departments.
Sécurité et efficacité de lʼutilisation d'endoprothèses métalliques d’apposition dans la gestion des collections de fluides post-opératoires: une vaste étude internationale multicentrique
Journal: Endoscopy (2019)

Les collections liquidiennes post-opératoires (CLPO) ne sont pas un évènement rare et constituent une source significative de morbi-mortalité, classiquement traitée par reprise chirurgicale ou drainage per cutanée sous contrôle radiologique. Le drainage endoscopique, écho-guidé a déjà été décrit, au moyen de prothèses plastiques ou métalliques couvertes, qui peuvent cependant se boucher ou migrer. De nombreuses études ont été publiées sur l’utilisation de prothèses métalliques d’apposition luminale pour le drainage de collections d’origine pancréatique. Les données dans le contexte de CLPO sont peu nombreuses. L’objectif de cette étude publiée par Yang et collaborateurs, était d’évaluer le drainage endoscopique de ces CLPO par des prothèses d’apposition.
THE TEACHING OF ANATOMY.
Journal: JAMA (1890)

This subject received considerable attention at the recent meeting of the British Medical Association. Mr.Lawson Tait, in his Address in Surgery, paid his respects to it in his usual vivacious and somewhat reckless style, and it received full attention in the Section of Anatomy and Physiology. Mr. Tait's strictures upon the prevailing methods of anatomical teaching were mainly bestowed upon two points—needless attention to details, and what he characterized as "that senseless system of biological training which has set in as a fashion at Cambridge, at Oxford, and at Edinburgh." In regard to the first point, the waste of time spent on details that are of no practical use to the physician, there are probably few who will not to a certain extent agree with him. One of the illustrations which he uses is perhaps even better than he was aware. "I remember," he says, "that we had to
NEW CONCEPTION OF SMALLPOX.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Complications of silicone elastomer prostheses
Authors: Gordon Taylor, C. Philip Larson
Journal: JAMA (1977)

We agree with Dr Harrison that anesthetic deaths are almost invariably preventable but continue to occur primarily because of human error. By definition, "adequate" monitoring<i>should</i>prevent unexpected cardiac arrests, but one of the thrusts of our study was the demonstration that usual and conventional monitoring does not prevent such occurrences; ergo, it is not always adequate. Foolproof monitoring is not yet available. One of the principal advantages of a national registry for cardiac arrests would be that it would permit a clearer delineation of the circumstances surrounding an unexpected cardiac arrest. Use of a standard reporting form, such as the one we have prepared, provides for a more complete evaluation of the conditions prevailing before, during, and after the cardiac arrest while the events are still fresh in mind. With more complete and reliable information that the registry would provide, one could classify the primary cause more
Electrochemotherapy for breast cancer - results from the INSPECT database
Authors: L.W. Matthiessen, M. Keshtgar, C. Kunte, E.-M. Grischke, J. Odili, T. Muir, P. Curatolo, D. Mowatt, J. Clover, S.H. Liew, H.F. Hansen, J. Newby, V. Letulé, E. Stauss, A.C. Humphreys, S. Banerjee, A. Klein, F. de Terlizzi, J. Gehl
Journal: Annals of Oncology (2016)
Forgiveness
Authors: Lane A. Gerber
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Optimal non-invasive screening strategy for non-alcoholic fatty liver disease in a prospective cohort of patients with type 2 diabetes
Authors: Veeral Ajmera, Jinho Jung, Keshin Purohit, Scarlett Lopez, Egbert Madamba, Sonia Bajwa-Dulai, Richele Bettencourt, Lisa Richards, Kathryn Fowler, Claude Sirlin, Rohit Loomba
Journal: Journal of Hepatology (2020)
Liver regeneration after hepatic ischemia and reduced liver autotransplantation in the rat
Authors: G Bolitho
Journal: Hepatology (1993)

Current knowledge of liver regeneration after reduced liver transplantation is limited. Warm ischemia is one component of the reduced liver transplantation procedure that could have an impact on the regenerative response. To study this effect, we performed partial hepatectomy on male Long-Evans rats, with animals divided into four groups: group 1 underwent partial hepatectomy only; group 2 underwent partial hepatectomy and 40 min of ischemia; group 3 underwent partial hepatectomy, 40 min of ischemia and portocaval shunt surgery; and group 4 underwent partial hepatectomy and orthotopic autograft surgery. Group 5 consisted of sham-operated animals. Animals were killed 4, 24, 48, 72 and 96 hr after surgery. Thymidine kinase activity, mitotic index, a liver mass index and ornithine decarboxylase levels were used as parameters of liver regeneration. Aspartate transaminase was recorded. Maximal thymidine kinase and mitotic index were observed in group 1 animals at 24 hr. In groups 2, 3 and 4 maximal thymidine kinase activity and mitotic activity were observed 24 hr later at 48 hr. The magnitude of the peak response in these groups appeared to correlate with the duration of portal venous occlusion, with greatest increases occurring in those groups where portal stasis was most prolonged. The increase in liver mass for these groups was also delayed with respect to group 1 animals. The anticipated peak in ornithine decarboxylase levels was seen at 4 hr in group 1. The ornithine decarboxylase response in the other groups was disorganized, with delay of the recorded peaks. Therefore surgical procedures involving warm hepatic ischemia result in a delay in the first wave of DNA synthesis and mitosis in regenerating rat liver. This delayed response may reflect the effects of denervation, stimulation of cytokine release or diversion of hepatocyte synthetic function toward essential protein synthesis at a time critical to the survival of the animal. (HEPATOLOGY 1993;17:273–279.)
Fibronectin and α5ß1 integrin mediate binding of &lt;I&gt;Pseudomonas aeruginosa&lt;/I&gt; to repairing airway epithelium
Authors: P. Roger, E. Puchelle, O. Bajolet-Laudinat, J-M. Tournier, C. Debordeaux, M-C. Plotkowski, J. H. M. Cohen, D. Sheppard, S. de Bentzmann
Journal: European Respiratory Journal (1999)

The normal rise of circulating endogenous glucocorticosteroids (GCS), in response to immunological stimuli, can be impaired in patients with inflammatory diseases. The aim of this study was to investigate whether abolition of the endogenous GCS response promotes local production of the pro-inflammatory cytokine, tumour necrosis factor (TNF)-alpha, in challenged airways and affects the cellular response in rats. In adrenalectomized or sham operated rats, the trachea and main bronchi were lavaged at various times after intratracheal instillation of low dose lipopolysaccharide (LPS). TNF-alpha in lavage fluid and plasma corticosterone were measured, and cells were differentiated. In adrenalectomized rats, LPS-induced in the airways a biphasic TNF-alpha release peaking at 2 and 6 h, whereas in sham operated rats the second peak was absent; probably inhibited by the strong rise of plasma corticosterone. The second peak was abolished in adrenalectomized rats by pretreatment with exogenous GCS. The LPS-induced neutrophil influx and a decrease in mononuclear cells were prolonged in adrenalectomized rats. In conclusion, abolition of the endogenous glucocorticosteroid response promotes the late release of tumour necrosis factor-alpha in the airways and prolongs the cellular response. This suggests that a normal rise of endogenous glucocorticosteroid after an immunological trigger contributes to a dampening of the late inflammatory activity.
Encopresis
Authors: W.H.G. Wolters
Journal: Psychotherapy and Psychosomatics (1971)

The most important studies on encopresis in children are reviewed. The various authors prove to differ widely in their views concerning the definition, aetiology and treatment of encopresis, so that on the whole the literature presents a rather confusing picture. A common shortcoming, for instance, is the one-sided approach which most authors take, limited as it is to either the somatic or the psycho-social angle. Only a very small number of researchers integrate both factors in their line of approach. Remarkably little attention is paid, for instance, to examination of the colon. The present author lays particular stress on the large number of variables involved in the aetiology and advocates a multiple therapeutic technique. A research project currently in progress is designed to discover differences in the aetiology and course of the disease in patients with and without demonstrable somatic disorder.
Commentaire du travail de Chevaux JB et al., pp. 103
Authors: Emmanuel Coron, Laurent Heyries, Max Barret
Journal: Endoscopy (2015)

See also: Clinical outcome in patients treated with endoscopic submucosal dissection for superficial Barrett’s neoplasiaEndoscopy 2015; 47(02): 103-112DOI: 10.1055/s-0034-1390982
Jumbled Lines
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risks for Bleeding in Patients with Pulmonary Embolism Treated with Thrombolytic Agents
Authors: Bimal P. Jain
Journal: Annals of Internal Medicine (1995)

Letters15 April 1995Risks for Bleeding in Patients with Pulmonary Embolism Treated with Thrombolytic AgentsBimal P. JainBimal P. JainSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-8-199504150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I suggest that only major bleeding at catheter insertion sites and not at other sites, such as intracerebral or retroperitoneal sites, be considered a complication of pulmonary angiography in patients receiving thrombolytic therapy. The reported risk for this complication would therefore be 10.6% (7 of 66 patients) and not 14% (18 of 129 patients) as calculated by Stein and colleagues [1]. To avoid this complication, they recommend giving thrombolytic therapy without pulmonary angiography if the calculated frequency (probability) of pulmonary embolism from clinical and lung scan evaluation is higher than 21%. I find this recommendation clinically unacceptable, ...References1. Stein PD, Hull RD, Raskob G. Risks for major bleeding from thrombolytic therapy in patients with acute pulmonary embolism. Consideration of noninvasive management. Ann Intern Med. 1994; 121:313-7. Google Scholar2. The PIOPED Investigators. Values of the ventilation/perfusion scan in acute pulmonary embolism. Results of the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED). JAMA. 1990; 263:2753-9. Google Scholar3. Dalla-Volta S, Palla A, Santolicandro A, Guntini C, Pengo V, Visioli O, et al. PALMS-2: Alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. Plasminogen Activator Italian Multicenter 2. J Am Coll Cardiol. 1992; 20:520-6. Google Scholar4. Levine M, Hirsh J, Cruickshank M, Neemech J, Turpie AG, et al. A randomized trial of a single bolus dosage regimen of recombinant tissue plasminogen activator in patients with acute pulmonary embolism. Chest. 1990; 98:1473-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1995Volume 122, Issue 8Page: 630-632KeywordsAngiographyBlood transfusionCatheterizationCathetersHemorrhageLungsPulmonary embolismRisk managementVeins ePublished: 15 August 2000 Issue Published: 15 April 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Orphan Drugs
Authors: Robert C. Hastings
Journal: JAMA (1983)

"Orphan drugs" are potentially useful drugs that have not been developed to the point of being made generally available. The fact that these drugs are not available is presumed to mean that lives that they could save are being lost and suffering that they could alleviate is being endured. Why aren't these orphan drugs available? The premise of<i>Orphan Drugs</i>is that they should be made available, that the present system fails to make them available, and that they cannot be made available until orphan drugs are acknowledged as a problem in our society. Much of the book is a multiauthored essay defining the problem, suggesting solutions, and calling for action—in short, persuading the reader that orphan drugs are a problem and inviting him to join in seeking a solution. After introducing the problem of orphan drugs with the story of a 27-year-old woman dying of a neurological disorder who
Effectiveness of sorafenib dose modifications on treatment outcome of hepatocellular carcinoma: analysis in real-life settings
Authors: Jeong Won Jang, Kwon Yong Tak, Heechul Nam, Jong Young Choi, Seung Kew Yoon, Si Hyun Bae, Chang Wook Kim, Jin Mo Yang, Sung Won Lee
Journal: Journal of Hepatology (2020)