tbuckley/cabot-search huggingface dataset:
GLUCAGON IN CONGESTIVE HEART FAILURE
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early Mesothelial Cell Proliferation after Asbestos Exposure: In Vivo and in Vitro Studies
Authors: Ian Y. R. Adamson
Journal: Environmental Health Perspectives (1997)

There is some evidence that proliferation of pleural mesothelial cells (MC) occurs soon after deposition of asbestos fibers.To study this effect, we instilled a single dose of 0.1 mg crocidolite into the lungs of mice for 1 and 6 weeks and counted labeled nuclei after 3H-thymidine (3HTI) injection.Short fibers (<1 pm) induced little change in the lung; they were mostly phagocytized and had a minimal effect on MC labeling.Long fibers up to 20 pm damaged the bronchiolar epithelium and were incorporated into connective tissue.Increased 3HT uptake was seen in fibroblasts and epithelial cells and also in MC, which peaked at 2% labeled at 1 week compared to near 0% labeling in controls.No fibers were found in or near labeled MC, which suggested that a cytokine generated in the lung during the early response phase might induce MC proliferation.To look for a cytokine effect in vitro, we instilled asbestos into rat lungs and, after 1 and 6 weeks, bronchoalveolar and pleural lavage fluids as well as macrophages were collected.Alveolar macrophages contained fibers, but pleural macrophages (PM) did not.After short-term culture, macrophage supernatants and the lavage fluids were tested on rat lung MC in culture.At 1 week, PM secreted growth factor(s) for MC, and the mitogenic effect was more pronounced with lavage fluids.No effects on MC were found using material prepared 6 weeks after asbestos.The early MC growth increase was not blocked by antibodies to cytokines, such as platelet- derived growth factor, fibroblast growth factors, or tumor necrosis factor, but was inhibited by anti-keratinocyte growth factor (anti-KGF).The results show that an early growth phase of MC after asbestos exposure appears unrelated to particle translocation to the pleura but is associated with cytokine release, most likely KGF, by lung cells.
Performance measures for upper gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative
Authors: Raf Bisschops, Miguel Areia, Emmanuel Coron, Daniela Dobru, Bernd Kaskas, Roman Kuvaev, Oliver Pech, Krish Ragunath, Bas Weusten, Pietro Familiari, Dirk Domagk, Roland Valori, Michal Kaminski, Cristiano Spada, Michael Bretthauer, Cathy Bennett, Carlo Senore, Mário Dinis-Ribeiro, Matthew Rutter
Journal: Endoscopy (2016)

Abbreviations CI: confidence interval EAC: early adenocarcinoma EMR: endoscopic mucosal resection ENT: ear, nose, and throat ESGE: European Society of Gastrointestinal Endoscopy FAP: familial adenomatous polyposis GAVE: gastric antral vascular ectasia HGD: high grade dysplasia LGD: low grade dysplasia MAPS: Management of precancerous conditions and lesions in the stomach OLGA: Operative Link for Gastritis Assessment OLGIM: Operative Link on Gastric Intestinal Metaplasia OR: odds ratio PEG: percutaneous endoscopic gastrostomy PICO: population/patient; intervention/indicator; comparator/control; outcome PPI: proton pump inhibitor QIC: Quality improvement committee SCC: squamous cell cancer UEG: United European Gastroenterology UGI: upper gastrointestinal tract
Health Status of Workers Exposed to Phthalate Plasticizers in the Manfacture of Artificial Leather and Films Based on PVC Resins
Authors: L. E. Milkov, M. V. Aldyreva, T. B. Popova, K. A. Lopukhova, Yu. L. Makarenko, L. M. Malyar, T. K. Shakhova
Journal: Environmental Health Perspectives (1973)
Tumor lysis syndrome after induction chemotherapy of small-cell bronchogenic carcinoma
Authors: N. J. Vogelzang
Journal: JAMA (1983)

THE TUMOR lysis syndrome, consisting of severe hyperphosphatemia, hyperkalemia, hyperuricemia, and hypocalcemia, occurs after the effective induction chemotherapy of rapidly growing malignant neoplasms. This syndrome has been reported to complicate the treatment of acute leukemia, malignant lymphoma, and Burkitt's lymphoma.<sup>1-3</sup>The metabolic abnormalities are thought to be secondary to the release of intracellular products after cell lysis.<sup>1</sup>We report herein a case of tumor lysis syndrome that occurred after induction chemotherapy of small-cell bronchogenic carcinoma. <h3>Report of a Case</h3> A 57-year-old female smoker was admitted to the hospital with a recent history of cough, malaise, and weight loss. Pertinent physical findings included normal vital signs, cervical adenopathy, and massive hepatomegaly. Chest x-ray film showed a right lower lobe infiltrate. Percutaneous liver biopsy and bone marrow biopsy specimens demonstrated metastatic small-cell bronchogenic carcinoma. Complete blood cell count was normal. Chemistry screen showed the following values: sodium, 138 mEq/L; potassium,
Abstracts
Journal: Journal of Clinical Investigation (1971)

Chronic uremia in man and animals results in a resistance to the biological effects of vitamin D3 (D3) and an abnor- mality in D3 metabolism.Since it has been established that 250HD3 is one of the biologically active circulating metabo- lites of D3, experiments were designed to study its metabolic fate in the uremic state.250HD3-3H was administered by jugular puncture to animals with experimentally induced chronic uremia and their pair-fed, age-matched controls. 24hr later the animals were sacrificed and urine, plasma, small intestine, liver, and muscle harvested for measurements of DNA, protein, and radioactivity.250HD3-3H metabolites were separated and isolated by silicic acid gradient elution techniques and liquid-liquid partition chromatography.Whereas less than 4% of the injected radioactivity was normally excreted in 24 hr, over 20% was recovered from the urine of uremic animals.In each instance, the majority of the excreted radioactivity was characterized as unaltered 25 OHD3-3H. 3.9 and 1.9% of the injected radioactivity was recovered from the intestine of normal and uremic animals respectively.The decrease in intestinal radioactivity was due primarily to a decrease both in 250HD3-3H and one of its polar metabolites.These alterations in 25OHD3-3H metabo- lism were also associated with a net decrease in intestinal protein synthesis as reflected by tissue protein:DNA ratios.Whereas the hepatic concentration of 250HD3-3H and its esterified derivatives were normal in the uremic animals, the muscle and bone content of 25 OHD3-3H were decreased.These studies demonstrate that the chronic uremic state results in an impairment of intestinal protein synthesis and a derange- ment in the metabolism and distribution of 25OHD3-3H.As such, they offer a reasonable explanation for the malabsorption of calcium and its resistance to vitamin D3 manifested by patients with chronic renal disease.12.
NERVOUSNESS IN SCHOOL CHILDREN.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 642: Increasing BMI is associated with tumor volume and uterine weight in endometrial cancer
Authors: Yingao Zhang, Nerlyne Desravines, Dominic T. Moore, Paola A. Gehrig, Leslie H. Clark, Victoria L. Bae-Jump
Journal: Cancer Research (2019)

Abstract Obesity and diabetes is associated with increased risk and worse outcomes in endometrial cancer (EC). Our previous work has found that obesity leads to more aggressive tumor behavior and a doubling of tumor size in EC mouse models. Thus, we explored the association between endometrial tumor volume (TV) and uterine weight (UW) as a function of BMI in EC patients. We performed a retrospective review of EC patients diagnosed and treated from 2005-2010 at a single tertiary care center. Tumor histology, dimensions, stage, grade, and UW were extracted from surgical pathology reports. Patient age, BMI, and diabetic status were also collected. TV was determined using the formula TV=l*d*w*pi/6. Independent variables include obesity classification, BMI, and diabetic status. Univariable and multivariable regression models were used to assess strength of association. A total of 564 EC patients were evaluated, with either endometrioid (n=522) or serous (n=42) histologies (Table 1). Within the endometrioid subgroup, associations were noted for both increased TV and UW with obesity (TV p=0.02; UW p&amp;lt;0.001) and BMI (TV p=0.007; UW p&amp;lt;0.001). Within the serous subgroup, increased TV was associated with obesity and BMI (p&amp;lt;0.001; p=0.007), but UW was only associated with obesity (p=0.005) and not BMI (p=0.07). Controlling for stage and grade, multivariable models demonstrated similar patterns with obesity status and BMI within both subgroups. Multivariable analyses also demonstrated that having diabetes (n=160) was associated with both higher TV and UW in the endometrioid subgroup (TV p=0.004; UW p=0.02), but not in the serous subgroup (TV p=0.71; UW p=0.12). Obesity and increasing BMI appear to be associated with both increased TV and UW in EC patients, consistent with our previously described findings in murine models. Diabetes was also associated with higher TV and UW, but was only significant in patients with endometrioid ECs. Our results may partially account for the worse outcomes seen in obese EC patients. Table 1EC HistologyMedianIQREndometrioid (n=522)Uterine Weight (g)Non-obese118.183.0-157.5Obese140.0103.8-200.0Tumor Volume (cm3)Non-obese3.6950.927-9.664Obese4.3591.419-14.216Serous (n=42)Uterine Weight (g)Non-obese116.667.4-166.6Obese189.8127.6-252.6Tumor Volume (cm3)Non-obese3.2490.601-9.382Obese23.8247.356-59.494 Citation Format: Yingao Zhang, Nerlyne Desravines, Dominic T. Moore, Paola A. Gehrig, Leslie H. Clark, Victoria L. Bae-Jump. Increasing BMI is associated with tumor volume and uterine weight in endometrial cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 642.
CHRISTMAS WEEK, 1897.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholangiocyte organoids are plastic and their identity is controlled by their local microenvironment
Authors: Fotis Sampaziotis, Daniele Muraro, Olivia C. Tysoe, Timothy Beach, Stephen Sawiak, Edmund Godfrey, Sara Upponi, Brandon Wesley, Jose Garcia-Bernardo, Teresa Brevini, Krishnaa Mahbubani, Giovanni Cannu, Richard Gieseck, Natalie Lie Berntsen, Victoria Mulcahy, Keziah Crick, Corina Fear, Sharayne Robinson, Lisa Swift, Daniel Ortmann, Anna Osnato, Stephanie Brown, Michael Murphy, William Gelson, George Mells, Susan Davies, Irum Amin, Paul Gibbs, Sarah Teichmann, Andrew Butler, Teik Choon See, Espen Melum, Chris Watson, Kourosh Saeb-Parsy, Ludovic Vallier
Journal: Journal of Hepatology (2020)
Detection of Hypertension
Authors: William J. Mroczek
Journal: JAMA (1975)

We evaluated past medical records and conducted a hypertension screening program in the outpatient clinic of a university hospital, a community hospital, and a city hospital, with the aid of specially trained high school students under the direction of a cardiovascular nurse. Fifty-one percent of the adult black outpatients had elevations of arterial blood pressure; one half of these patients were aware of a history of hypertension. Analysis of the clinic records showed that many patients who had made multiple visits to the clinic had never had a blood pressure recorded in their charts. If progress is to be made in the detection of hypertension, blood pressures must be routinely determined. This should be incorporated into all clinic routines, particularly in clinics staffed by physicians-in-training. (<i>JAMA</i>231:1264-1266, 1975)
Multiple Pseudofractures
Authors: Otto E. Aufranc, William N. Jones, William H. Harris
Journal: JAMA (1964)

Dr. Harris: A 47-year-old married housewife was admitted to the hospital with the chief complaint of difficulty in walking. This problem had been present for about two years and was increasing in severity. The patient was born in this country of Italian parents and, as far as she knew, had had no difficulty in childhood. She had been short in stature throughout her life. When she was in the seventh and eighth grades, she recalls, she was the shortest child in her class. Her menstrual periods began at the age of 16 and ceased at the age of 28 without hot flashes. Approximately two years before admission, she began to notice that when she stood after sitting for any length of time she would have difficulty beginning her gait. After she had taken a few steps, walking produced no particular pain. She also noticed that she was developing a waddling
Physical Diagnosis.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis
Journal: BMJ (2010)

Objective To investigate whether calcium supplements increase the risk of cardiovascular events.Design Patient level and trial level meta-analyses.Data sources Medline, Embase, and Cochrane Central Register of Controlled Trials (1966-March 2010), reference lists of meta-analyses of calcium supplements, and two clinical trial registries.Initial searches were carried out in November 2007, with electronic database searches repeated in March 2010.Study selection Eligible studies were randomised, placebo controlled trials of calcium supplements (≥500 mg/day), with 100 or more participants of mean age more than 40 years and study duration more than one year.The lead authors of eligible trials supplied data.Cardiovascular outcomes were obtained from self reports, hospital admissions, and death certificates.Results 15 trials were eligible for inclusion, five with patient level data (8151 participants, median follow-up 3.6 years, interquartile range 2.7-4.3 years) and 11 with trial level data (11 921 participants, mean duration 4.0 years).In the five studies contributing patient level data, 143 people allocated to calcium had a myocardial infarction compared with 111 allocated to placebo (hazard ratio 1.31, 95% confidence interval 1.02 to 1.67, P=0.035).Non-significant increases occurred in the incidence of stroke (1.20, 0.96 to 1.50, P=0.11), the composite end point of myocardial infarction, stroke, or sudden death (1.18, 1.00 to 1.39, P=0.057), and death (1.09, 0.96 to 1.23, P=0.18).The meta-analysis of trial level data showed similar results: 296 people had a myocardial infarction (166 allocated to calcium, 130 to placebo), with an increased incidence of myocardial infarction in those allocated to calcium (pooled relative risk 1.27, 95% confidence interval 1.01 to 1.59, P=0.038).Conclusions Calcium supplements (without coadministered vitamin D) are associated with an increased risk of myocardial infarction.As calcium supplements are widely used these modest increases in risk of cardiovascular disease might translate into a large burden of disease in the population.A reassessment of the role of calcium supplements in the management of osteoporosis is warranted.
The University of California, Irvine, First International Cancer Conference
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article The University of California, Irvine, First International Cancer Conference Get access JNCI: Journal of the National Cancer Institute, Volume 75, Issue 4, October 1985, Page 799, https://doi.org/10.1093/jnci/75.4.799-b Published: 01 October 1985
Development
Authors: Grey Brown
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Compelled medical treatment of pregnant women
Authors: Stephen E. Whitney
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I was profoundly distressed with the ethical reasoning expressed in Nelson and Milliken's article.<sup>1</sup>The authors correctly state that the issues of fetal rights, legal and ethical, are hotly debated. It is understandable that physicians would seek the help of the courts to judge what is the just course of action when a fetus' health or life is jeopardized by its mother's behavior. The authors' contention that to seek a court ruling on life and death issues is unethical because it invades the mother's privacy is a gross distortion of ethical reasoning. Any issue brought to judicial review, whether criminal or civil, involves a discovery process that invades one's privacy. Certainly the mother might be psychologically ill-disposed to defend her choices while pregnant, but the psychological states of a person standing trial in a criminal action or of the parties in a contested divorce are no
Transactions of the College of Physicians of Philadelphia, Vol. VI., 1883.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal