tbuckley/cabot-search huggingface dataset:
Outbreak of group A streptococcus septicemia in children. Clinical, epidemiologic, and microbiological correlates
Authors: M. C. Wheeler
Journal: JAMA (1991)

<h3>Objective.</h3> —To determine the epidemiologic, clinical, and microbiological features of group A streptococcus septicemia in children. <h3>Design.</h3> —A descriptive series of 34 cases over an 11-year period from 1980 through 1990. <h3>Setting.</h3> —An academically affiliated tertiary-care pediatric hospital, the principal referral center for the state of Colorado and surrounding states. <h3>Participants.</h3> —Thirty-four patients with positive blood cultures for group A streptococcus (33 medical records were available). <h3>Main Outcome Measures.</h3> —Yearly incidence and clinical features of cases; microbiological features of isolated organisms. <h3>Results.</h3> —There was a significant increase (P =.01) in the incidence of group A streptococcus bacteremia over an 11-year period, with 14 (41%) of these cases occurring in 1989 and 1990. Patients had a rapidly progressing illness, usually without preceding pharyngitis. The prominent M and T types were 1 (4) and 12 (4). Eleven (73%) of the 15 strains produced pyrogenic exotoxin B that significantly correlated with production of proteinase. <h3>Conclusion.</h3> —There appears to be an increase in group A streptococcus bacteremia in children that is associated with a strain phenotype that suggests a change in organism virulence. (<i>JAMA</i>. 1991;266:533-537)
Essentials of Anatomy and Manual of Practical Dissection.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PWE-128 Romiplostim’S Effect to Optimize SVR With Telapravir, Ribavirin, and Peg Interferon-Alfa 2A In Thrombocytopenic Cirrhotics with Chronic Hepatitis C. A Placebo Controlled Prospective Clinical Trial: Restraint C Trial: Abstract PWE-128 Table
Authors: P Basu, N J Shah, S Farhat, R Siriki, K Mittimanj, M Rahaman, S Atluri
Journal: Gut (2013)

<h3>Introduction</h3> Treating HCV cirrhotic patients with thrombocytopenia is challenging, often requiring dose reduction/discontinuation to avoid complications. Significant dose reduction affects response guided therapy (RGT); affecting outcomes. Thrombopoietin (TPO) agonists are used to avoid disruption or therapeutic failure to optimise SVR. This study evaluated the use of TPO agonist in thrombocytopenia in cirrhotics with CHC. <h3>Methods</h3> Forty five (n = 45) cirrhotic treatment experienced CHC-GT1 patients wererecruited with mean MELD 16, mean platelet count 95. Group A-(n = 15) placebo plus reduced dose of p-IFN with Ribavirin and Telaprevir. Group B (n = 15) Romiplostim 500mcg lead in 1 month prior to initiation of therapy and SOC with Telaprevir. Group C (n = 15) Elthrombopag 50mg orally daily lead in prior 15 days and SOC with Telaprevir for 12 weeks. RGT was analysed with serial platelet counts, haemoglobin/hematocrit, absolute neutrophils count and platelet antibodies. HCV RNA 1ST, 2ND, 4TH, 12TH 24TH, 36TH and 60th weeks for SVR. <h3>Results</h3> <h3>Conclusion</h3> This study demonstrates the efficacy of Romiplostim in thrombocytopenic cirrhotics in optimising SVR (Group A-53%, Group B-67% and Group C-60%). A larger trial is needed to validate. <h3>Disclosure of Interest</h3> None Declared.
Asbestos Fibers, Plasma and Inflammation
Authors: John A. Hamilton
Journal: Environmental Health Perspectives (1983)

Fibrin clots have been detected at sites of inflammation, and kinins have been implicated as mediators of the vascular phenomena of acute inflammation, systemic shock, and disseminated intravascular coagulation. It is now reported that both negatively and positively charged asbestos fibers shorten the partial thromboplastin time of human plasma, indicating coagulation of the plasma. A sample containing short (less than 5 micron in length) chrysotile fibers is ineffective. Only the negatively charged amphiboles (crocidolite and amosite) are able to activate factor XII (Hageman factor). This particular effect of the amphiboles is enhanced by high molecular weight kininogen and leads to kinin formation.
Magnesium Metabolism
Authors: Warren E. C. Wacker, Bert L. Vallee
Journal: New England Journal of Medicine (1958)

Magnesium Metabolism of ManMagnesium has been known to be present in the human body for at least a hundred years; indeed, in 1859, Oliver Wendell Holmes included magnesium in a humorous poem that incorporated a list of the elements of which he thought man to be composed, though his "evidence" is not given.136 An accurate measurement of the human body content of magnesium was not made until almost a hundred years later.137 It is now known that the adult body contains from 21 to 28 gm. of magnesium, or about 43 mg. per kilogram of fat-free tissue. At birth, . . .
Hepatocyte Growth Factor (HGF) Induces Interleukin-11 Secretion From Osteoblasts: A Possible Role for HGF in Myeloma-Associated Osteolytic Bone Disease
Authors: Øyvind Hjertner, Maria Lyngaas Torgersen, Carina Seidel, Henrik Hjorth-Hansen, Anders Waage, Magne Børset, Anders Sundan
Journal: Blood (1999)
Spherocytic Hemolytic Anemia and Acute Cholecystitis Caused by Clostridium Welchii
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Shall The Journal be Removed to Washington?
Authors: Harold N. Moyer
Journal: JAMA (1891)

<h3>To the Editor:</h3> —In the last issue Dr. Solis-Cohen considers the matter of the removal ofThe Journal. A careful perusal of his letter shows it to be a conglomerate admixture of argument and assertion, seasoned with a few facts. Dr. Cohen in his letter starts with the question, where canThe Journalbe best edited and best serve the interests of the Association. Then he proceeds to find fault with the management ofThe Journal, stating that it has identified itself with local interests, that it has not attracted the work of the best men, that it has not been sufficiently careful in rejecting poor papers, and finally, that its abstracts and selections have not been up to standard. The editorial department he considers to have been one of the strongest features ofThe Journal. With this sufficiently perspicuous statement of the shortcomings ofThe Journal, the writer proceeds
Abstract 008: Risk Factors for Type 2 Diabetes Mellitus Preceded by β-cell Dysfunction, Insulin Resistance, or Both: The Cardiovascular Health Study
Authors: Fumiaki Imamura, Kenneth J Mukamal, James B Meigs, Jose A Luchsinger, Joachim H Ix, David S Siscovick, Dariush Mozaffarian
Journal: Circulation (2012)

Background: Type 2 diabetes mellitus (DM) results from insulin resistance (IR), pancreatic β-cell dysfunction, or both. We hypothesized that risk factors could differ for DM preceded predominantly by IR, β-cell dysfunction, or both. This hypothesis is particularly important for older adults, in whom β-cell dysfunction may be relatively common. Methods: During 18 years of follow-up among 3,899 older adults free of DM (mean±sd age =73.0±5.8), we identified 274 incident DM cases by DM medication use, fasting glucose (≥126 mg/dL), or 2-hour post-challenge glucose (≥200 mg/dL), for whom homeostatic model assessments for IR (HOMA-IR) and β-cell function (HOMA-B) were assessed after baseline and before DM diagnosis. Using median cutoffs of the follow-up HOMA-IR and HOMA-B, we subclassified incident DM into DM preceded by IR only (n=112), β-cell dysfunction only (n=70), or both (n=77). Using multivariate competing-risk Cox models, we tested whether DM risk factors were differentially associated with risk of each DM subclass. Results: Elevated triglyceride levels (≥150 mg/dL) and impaired fasting glucose (100-125 mg/dL) were each positively associated with DM, irrespective of the DM subclass. Other DM risk factors of older age, overweight, obesity, low HDL cholesterol, and hypertension had substantially varying relationships with risk of different DM subclasses (p&lt;0.001 for the variations). For example, overweight (BMI=25-29.9 kg/m2) and obesity (BMI≥30 kg/m2) were each positively associated with DM preceded by IR only (hazard ratio [95% CI]= 2.21 [1.25-3.92] and 5.02 [2.81-9.00], respectively), but with a significant inverse association with DM preceded by β-cell dysfunction only (0.61 [0.37-1.00] and 0.33 [0.14-0.80], respectively) (Figure). Conclusions: Among older adults, some DM risk factors differ substantially depending on HOMA-IR or HOMA-B subclassification. These findings support our hypothesis of heterogeneity in incident DM, especially among older adults.
Adverse health outcomes in relationship to hypogonadism (HG) after platinum-based chemotherapy: A multicenter study of North American testicular cancer survivors (TCS).
Authors: Mohammad Issam Abu Zaid, Alvaro G. Menendez, Omar El Charif, Chunkit Fung, Patrick O. Monahan, Darren R. Feldman, Robert James Hamilton, David J. Vaughn, Clair Beard, Ryan Cook, Sandra K. Althouse, Howard D. Sesso, Shirin Ardeshirrouhanifard, Paul C Dinh, Lawrence Einhorn, Sophie Fosså, Lois B. Travis
Journal: Journal of Clinical Oncology (2017)

LBA10012 The full, final text of this abstract will be available at abstracts.asco.org at 2:00 PM (EDT) on Friday, June 2, 2017, and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Saturday edition of ASCO Daily News.
Evolving imaging in biliary disease: quantitative magnetic resonance cholangiopancreatography findings correlate with the modified Amsterdam score in patients with primary sclerosing cholangitis
Authors: Lin Cheng, Katherine Arndtz, Marc Goldfinger, Palak Trivedi, Marija Mavar-Haramija, Andrea Dennis, Ged Ridgway, Carlos Ferreira, Andrea Borghetto, Matt Kelly, John Michael Brady, Rajarshi Banerjee, Kartik Jhaveri, Gideon Hirschfield
Journal: Journal of Hepatology (2020)
Medicine at a Glance
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A SIMPLE APPARATUS FOR ADMINISTERING OXYGEN
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dissection sous-muqueuse endoscopique ou résection chirurgicale par gastrectomie pour les lésions néoplasiques superficielles gastriques: résultats d’une étude prospective comparative
Journal: Endoscopy (2018)

Les lésions néoplasiques superficielles gastriques peuvent être traitées par dissection sous-muqueuse (ESD) ou par gastrectomie avec curage ganglionnaire. Cependant, il n’existe pas de recommandation claire concernant le traitement à proposer en première intention en raison de peu d’études comparatives disponibles. La majorité des études est en effet rétrospective et aucune ne s’est intéressée à l’impact des traitements sur la qualité de vie des patients.
Treatment of spina bifida cystica.
Journal: BMJ (1973)

A a 6 Womreatinagedt6.wetetanglomustelndvsumoture in hnumofmal gutaaortic glypnode.Th tumourscll (lmninms as they are ordinarily seen.Although not well seen at this magnification, the tumour cells have the features of glomus cells, wsth rather small deeply stained nucleus and distinct but relatively narrow cytoplasmsc rim.(Haematoxylin-eosin. x 160.) tainly no justification for categorizing all glomus tumours as hamartomatous as, re- grettably, I must admit to having done else- where.3The interpretation of the histological picture in these cases is admittedly debatable, if not controversial.Nevertheless, it cannot be maintained that they are all misinter- preted instances of "haemangiopericytoma," Kaposi's sarcoma, or other accepted varieties
Constitutive Activation of STAT5 and Bcl-XL Overexpression Can Induce Endogenous Erythroid Colony Formation in Human Primary Cells.
Authors: Loïc Garçon, Chloe James, Catherine Lacout, Valérie Camara-Clayette, Valérie Ugo, Martine Raphael, William Vainchenker
Journal: Blood (2005)
THE STUDY OF ALCOHOL.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac Involvement in Rheumatoid Arthritis.
Authors: AbdelMohsen Nomeir
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Cardiac Involvement in Rheumatoid Arthritis.AbdelMohsen Nomeir, M.D., Robert Turner, M.D., Earl Watts, M.D., David Smith, M.D., George West, M.D., John Edmonds, M.D., F.A.C.P.AbdelMohsen Nomeir, M.D.Search for more papers by this author, Robert Turner, M.D.Search for more papers by this author, Earl Watts, M.D.Search for more papers by this author, David Smith, M.D.Search for more papers by this author, George West, M.D.Search for more papers by this author, John Edmonds, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-833_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis is the first prospective study comparing physical and electrovector-, and echo-cardiographic examination in studying the nature and extent of cardiac disease in normal controls and patients with chronic classic rheumatoid arthritis. To date 25 patients with rheumatoid arthritis have been evaluated and the data analyzed in this ongoing study. On physical examination there were no abnormal cardiac findings. Electrocardiographic studies showed: abnormal ST-T changes in three patients, T-wave abnormalities in another three patients, and evidence of old inferior myocardial infarction in one patient. Although several of the patients with rheumatoid arthritis showed low-voltage QRS vectors, there was no statistically... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Winston-Salem, North Carolina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEchocardiography of Heart and Pericardial Effusion 1 May 1973Volume 78, Issue 5Page: 833-833KeywordsElectrocardiographyHeart diseasesMyocardial infarctionProspective studiesRheumatoid arthritis Issue Published: 1 May 1973 PDF DownloadLoading ...
Methadone Maintenance
Authors: Robert C. Wolfe
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Detoxification from methadone maintenance therapy is the subject of a study and of separate editorial comment in the same issue ofThe Journalby the same author, Dr. Vincent Dole (226:747 and 780, 1973). The optimal dosage and duration of medication are important subjects medically, economically, and, as Dr. Dole suggests, politically. In his initial report inThe Journal(193:646, 1965), Dr. Dole promised control studies "with social support but without medication."<sup>1</sup>Not only has this not been accomplished by his group, but control studies of different dosages have not been reported by them. Berry has reported careful doubleblind studies<sup>2</sup>of maintenance dosages of 100 and 50 mg daily, and found no significant differences in results. Also, results similar to Berry's have been found by Goldstein and co-workers.<sup>3</sup>Yet, despite this documented evidence, Cushman and Dole state, "new patients, in our opinion, should be
The prophylactic effect of aprotinin on intraoperative bleeding in liver transplantation: A randomized clinical study
Authors: L Garcia-Huete
Journal: Hepatology (1997)

Fibrinolysis has been recognized as an important cause of intraoperative bleeding during orthotopic liver transplantation (OLT). Several investigators have used prophylactic administration of aprotinin in patients to inhibit fibrinolysis and to decrease transfusion requirements, morbidity, and mortality. Nevertheless, the role of aprotinin in this situation is not yet clear. The goal of this study was to determine the effects of prophylactic administration of aprotinin on intraoperative bleeding and blood requirements, and on hemostatic changes during OLT. Eighty consecutive patients were included in a double-blind, prospective study and were randomized in two groups. In group A (n = 39), an initial dose of 2 × 106 kallikrein inactivator units (KIU) of aprotinin was administered in the induction of anesthesia followed by infusion of 5 × 105 KIU/h until the end of the procedure. The control group (n = 41) received an identical volume of saline solution. The majority of the operations were performed with vena cava preservation (piggy-back technique) without venovenous bypass. During the anhepatic phase, a significant increase in levels of tissue plasminogen activator, thrombin- antithrombin complexes (TAT) and D-dimers (DD) was noted in both groups. A significant increment of TAT was observed in group A during reperfusion. The remaining hemostatic parameters were similar in both groups. Intraoperative requirements of packed red cells, fresh-frozen plasma (FFP), platelets, and cryoprecipitate were similar in the two groups. Our results suggest that prophylactic administration of aprotinin is not useful in reducing bleeding and blood product requirements during OLT.