tbuckley/cabot-search huggingface dataset:
06.10 Effects of resveratrol and a resveratrol-salicylate hybrid molecule on activation of human cd4<sup>+</sup> t- cells
Authors: Katrin Goldhahn, Burkhard Kloesch, Farid Aldawsari, Carlos Velazques-Martinez, Klaus Schmetterer, Guenter Steiner
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Aberrant T-cell responses are crucially involved in the pathogenesis of systemic autoimmune diseases such as rheumatoid arthritis (RA) leading to chronic inflammation and organ damage. Consequently, substances modulating T-cell activation may have therapeutic benefit in RA and related rheumatic diseases. Resveratrol is a natural occuring polyphenol mainly produced in plants. The beneficial effects of resveratrol are due to its anti-inflammatory, anti-carcinogenic and anti-oxidant activities. The aim of this study was to compare the effects of resveratrol and a novel resveratrol-salicylate hybrid molecule (C10) on human CD4<sup>+</sup> T-cells. <h3>Methods</h3> CD4<sup>+</sup> T-cells were isolated from healthy donors and pre-incubated with different concentrations of resveratrol or C-10 before being stimulated with anti-CD3/anti-CD28 antibodies. After 24 hour and 72 hour, respectively, cell culture supernatants were harvested and IL-2, IFN-γ and TNF-α release were quantified by ELISA. Proliferation rate was measured by thymidine incorporation. In addition, the up-regulation of the early activation markers CD25, CD69, CD71 and CD98 was analysed and phosphorylation of the MAP-kinase ERK as well as AKT and SRP6 was determined by western blot or flow cytometry. <h3>Results</h3> Inhibition of IL-2, IFN-γ and TNF-α release was significantly more effective when the cells were treated with C-10 as compared to resveratrol. Thus, a decrease of cytokine expression was observed already at 6.25 µM C-10 whereas resveratrol inhibited cytokine production only at 25 µM or 50 µM significantly. Moreover, the proliferation rate was significantly more decreased in the presence of C-10. The expression of CD25, CD69, CD71 and CD98hc was reduced to a similar degree by both compounds. Furthermore, phosphorylation of ERK, Akt and S6RP was attenuated when the cells were incubated with resveratrol or C-10. <h3>Conclusion</h3> Our data demonstrate that C-10 suppressed cytokine secretion and proliferation more effectively than resveratrol. Both compounds influence the phosphorylation of important signalling molecules. Thus, the resveratrol-salicylate hybrid molecule C-10 significantly amplified the effects of resveratrol in CD4<sup>+</sup> T- cells and might be used in the future for treatment of RA and other T-cell driven autoimmune diseases.
Physical activity and risk of gastrointestinal hemorrhage in the elderly
Authors: S. D. Phinney
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Dr Pahor and colleagues<sup>1</sup>report the intriguing association between habitual physical activity and reduced gastrointestinal hemorrhage (GIH) and discuss the potential for a direct causal relationship. An alternate possibility is an underlying causal factor common to both. A potential common factor is a reduced proportion of arachidonic acid in membranes of the gastrointestinal mucosa and muscles. Membrane arachidonate is the substrate for mucosa-protective prostaglandins, and reduced muscle membrane arachidonate is associated with insulin resistance (ie, reduced enpheral glucose disposal).<sup>2</sup>Insulin resistance results in reduced muscle glycogen deposition, and the level of muscle glycogen correlates with improved endurance performance.<sup>3</sup>Thus, it is possible that the elderly, for whom walking may represent a high level of endurance performance, choose to exercise because membrane composition enables them to do so, and the same membrane composition protects against ulceration. We have reported considerable variability in phospholipid arachidonate among
CADAVERIC SPASM.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interaction of Erythrocyte Membranes with Particulates
Authors: Abramo C. Ottolenghi, Laurie B. Joseph, Howard A. I. Newman, Ralph E. Stephens
Journal: Environmental Health Perspectives (1983)

Chrysotile fibers promoted the fusion of human erythrocyte membranes and the hemolysis and fusion of fowl erythrocytes. Amosite and glass fibers did not show the same effect. These findings provide a model for the internalization of the fibers by animal cells.
Screening tests
Authors: P. Sedgwick
Journal: BMJ (2009)

A new rapid urine test was evaluated as a screening tool for Chlamydia trachomatis infection in men.1 The test was compared with the gold standard diagnostic test for chlamydia infection—the polymerase chain reaction (PCR) assay. The rapid urine screening test was reported to have a sensitivity of 82.6% and specificity of 98.5%. Which of the following statements, if any, are true?
Intubation of the trachea in the critical care setting
Authors: C. Natanson
Journal: JAMA (1985)

SKILL at intubation of the trachea is an essential part of the medical repertoire of any physician who has primary care responsibility for patients in a critical care setting. It is common practice in hospitals today to perform tracheal intubation on an emergency or elective basis for ventilatory assistance, high-flow oxygen administration, bronchial hygiene, or airway protection. This article will give the physician not experienced in intubation a general background in the considerations and decisions the experienced laryngoscopist may make when intubating a critically ill patient. This article cannot hope to cover all the materials and techniques used in intubation, but will briefly discuss the key anatomy of the upper airway and the equipment, drugs, and techniques in intubation of the trachea that might be used in a critical care setting. The practice of intubation and airway management should be acquired in a controlled setting under knowledgeable supervision. <h3>Anatomy</h3> The
Evaluation of Experimental Trials of Therapy in Multiple Sclerosis
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Imported Dengue--United States, 1996
Journal: JAMA (1998)

Dengue is a mosquito-transmitted acute disease caused by any of four dengue virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4) and characterized by the sudden onset of fever, headache, myalgia, arthralgia, rash, nausea, and vomiting. This disease is endemic in most tropical areas of the world and has occurred in U.S. residents returning from travel to such areas. CDC maintains a laboratory-based passive surveillance system for imported dengue among U.S. residents. This report summarizes information about cases of imported dengue among U.S. residents for 1996, which indicated that most persons for whom travel history was known probably acquired infection in the Caribbean islands or Asia.
Absence of P2 protein in swine flu vaccines
Authors: S. W. Brostoff
Journal: JAMA (1982)

To test whether possible contamination with the neuritogenic P<sub>2</sub>protein from peripheral nerve myelin contributed to the increased incidence of Guillain-Barré syndrome during the national influenza immunization program, monovalent and bivalent vaccines from each manufacturer were tested using a recently developed radioimmunoassay for P<sub>2</sub>protein. No P<sub>2</sub>protein was found in any of the vaccines tested. (<i>JAMA</i>1982;247:495)
Nouns and adjectives
Authors: C. G. Roland
Journal: JAMA (1967)

Nouns designate "things" or abstractions. And adjectives limit nouns. This arrangement seems simple enough at the "see the red ball" level. However, when we consider the more complex subject of medical writing, we see that authors frequently misuse these parts of speech. The benign connective tissue new growth known as granuloma pyogenicum is usually a single rapidly-growing red-to-purplish small pedunculated raspberry-like lesion often varying in size from that of a pea to that of a cherry. This example contains several instances of overuse of modifiers, especially adjectives. The noun "growth" is modified by a long string of adjectives plus "tissue," a noun-used-as-an-adjective. And worse is the<i>single rapidly-growing red-to-purplish small pedunculated raspberry-like lesion</i>; in this breath-taking conglomeration we find that adjectives ("single," "red-to-purplish," "small," etc), a noun ("raspberry"), and an adverb-verbal combination ("rapidly-growing") all modify the noun "lesion." To correct this type of long-chain run is relatively easy. For example,
Correction
Journal: Journal of Clinical Investigation (1989)

Our manuscript defining the a 1-antitrypsin NullManawa mutation at the DNA level and the abnormalities in a l-antitrypsin gene expression associated with this mutation was submitted to The Journal ofClinical Investigation in December 1987.Subsequently, but before publication of our article in The Journal of Clinical Investigation, the serum a I-antitrypsin phenotype and lung function tests ofthe same family were published by D. W. Cox and H. Levison [ 1988.Emphysema ofearly onset associated with a complete deficiency of alpha-I -antitrypsin (null homozygotes).Am.Rev. Respir.].This reference was inadvertently omitted in the revision ofour article.The two articles are complementary and consistent; the Cox et al. article was the first to describe the family, while ours defines the mutation and its consequences at the gene level.We apologize to Cox et al. that the reference was not added, and investigators who work in this area should be aware that families are identical.
Emergency Medicine
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Operative Gynecology.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transplantation Pathology
Authors: Bruce A. Jones
Journal: JAMA (2010)

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Menstruation
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DOCTOR'S HOLIDAY.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Griseofulvin-warfarin antagonism
Authors: S. I. Cullen
Journal: JAMA (1967)

THE DEMONSTRATION that the metabolism of one drug can alter the metabolism of another has occasioned considerable interest.<sup>1</sup>Recent experimental work has shown that an increase within cells of the liver of smooth-surfaced endoplasmic reticulum parallels an increase of this altered metabolism.<sup>2</sup>Of further interest is the fact that the same or similar loci seem to be implicated in cholesterol synthesis.<sup>3</sup>Because it has been reported that the metabolism of both griseofulvin and coumarin congeners are increased by treatment with phenobarbital, presumably via enzyme induction,<sup>4,5</sup>it seemed within reason that one of these might act as an inducer to accelerate metabolism of the other. It should be noted, however, that the fact that a drug either acts as an inducer or is subject to altered metabolism via enzyme induction does not necessarily indicate that it will function in both capacities. <h3>Report of Cases</h3><h3>Case 1.—</h3> A
Addison’s disease
Authors: Bijay Vaidya, Ali J Chakera, Catherine Dick
Journal: BMJ (2009)

Diagnosis and management of this easily missed condition Addison's disease (also known as primary adrenal insufficiency) is a chronic disorder of the adrenal cortex resulting in inadequate secretion of glucocorticoid and mineralocorticoid. The commonest cause of Addison's disease in developed countries is autoimmune disorder and in developing countries is tuberculosis.1 #### Case scenario A 34 year old woman presented with a 12 month history of increasing tiredness, anorexia, weight loss, and depression. During that period, she had tried two different antidepressant tablets without benefit. She saw her general practitioner's locum, who thought she looked tanned. Her blood pressure was 90/60 mm Hg, although it had always tended to be low. Her serum sodium concentration was 130 (normal range 135-145) mmol/l and potassium concentration was 5.7 (normal range 3.5-5.5) mmol/l. A short Synacthen (tetracosactide) test showed an inadequate serum cortisol response, which together with raised plasma adrenocorticotrophic hormone confirmed the diagnosis of Addison's disease. #### How common is Addison's disease?
Abstract 4774: Engineering an oncolytic adenovirus to target CEA in colorectal cancer
Authors: Jessica C. Schaumburg
Journal: Cancer Research (2019)

Abstract Colorectal cancer is the second leading cause of cancer-related deaths in the United States and the third most commonly diagnosed cancer overall. Screening methods can identify precancerous polyps before they progress, leading to five-year survival rates of 92%. However, if diagnosed in later stages the survival rates decrease to 12%. While treatment options are available for advanced stages, they remain inadequate to affect overall survival. Thus, new therapies are needed to improve treatment outcomes. Oncolytic virotherapy is a unique therapeutic approach in which a virus is genetically modified to target cancer cells while sparing normal tissue. Oncolytic virotherapy takes advantage of the lytic properties of the viral life cycle. These viruses are used replicate inside cancer cells, lyse them and spread to adjacent cells throughout the tumor. The adenovirus is a well-characterized vector that is easily manipulated and produced and is capable of infecting a wide range of cells. However, the endogenous receptor for adenovirus, the Coxsackie and adenovirus receptor (CXADR), is often downregulated in cancers, thus decreasing the ability to selectively infect cancer cells. In this study, an adenovirus was genetically engineered to present the single variable domain (VHH) derived from a camelid heavy chain antibody B2. The B2 antibody recognizes the human carcinoembryonic antigen (CEA), which is often overexpressed in a variety of cancers, including colorectal cancer. Here, the wild-type fiber and knob domain of the adenovirus fiber gene was replaced with a modified T4 fibritin fiber linked to the B2 VHH. To provide for visual tracking of adenovirus infection and biodistribution, a red fluorescent protein (RFP) marker gene was also fused to the capsid protein IX (pIX). This virus was rescued and amplified in the HEK293 F28 packaging cell line with a final round of amplification in HEK293 cells. The virus was purified by CsCl ultracentrifugation and dialysis. The resulting viral stock was titered and characterized for the presence of the modified fiber and knob. Subsequently, the vector was modified to express the human sodium-iodide symporter (NIS) transgene, to allow for noninvasive imaging of the adenovirus uptake and replication as well as radiotherapy using 131I. Further experiments will be completed to confirm viral selectivity for CEA and subsequent lysis of colorectal cancer cells. The results of this study will advance targeting oncolytic adenoviruses to metastatic colorectal cancer. Note: This abstract was not presented at the meeting. Citation Format: Jessica C. Schaumburg. Engineering an oncolytic adenovirus to target CEA in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4774.