tbuckley/cabot-search huggingface dataset:
The Aging Thyroid
Authors: Clark T. Sawin
Journal: JAMA (1979)

Of 344 relatively healthy persons older than 60 years, 22 (5.9%) had a clearly elevated level of serum thyrotropin (TSH) (&gt;10 μU/mL), a finding more common in women than in men. Ten of the 22 had low values for serum thyroxine (T<sub>4</sub>) and free T<sub>4</sub>(FT<sub>4</sub>) index, but only one had a low value for serum triiodothyronine (T<sub>3</sub>) or free T<sub>3</sub>(FT<sub>3</sub>) index. A further 14.4% had a slightly elevated level of serum TSH (&gt;5≤10 μU/mL), but none had low values for serum T<sub>4</sub>or FT<sub>4</sub>index. Age alone has little effect on the measurements of T<sub>4</sub>; age is associated with slightly lower T<sub>3</sub>levels, but only in men 60 years or older or in women 80 years or older. Longitudinal studies should determine if a slightly elevated serum TSH rises further with age and if there is a causal relationship between a high level of serum TSH and cardiovascular disease. (<i>JAMA</i>242:247-250, 1979)
THE PRESIDENT'S MESSAGE.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Surgery
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1962)

ColonHirschsprung's DiseaseThe treatment of aganglionosis of the colon by Swenson's59 operation has proved entirely satisfactory in his hands. Thus, in his long-term results, only 5 of 200 patients were troubled by severe constipation, diarrhea or incontinence. Other surgeons have reported trouble with these sequelae. Duhamel60 has described a new procedure, in which a primary anastomosis is avoided; the colon is brought down through the perineum posterior to the rectum, and later the wall dividing colon and rectum is crushed by a clamp.Ehrenpreis61 has found the Duhamel operation very satisfactory, with no deaths and no complications in 8 . . .
Abstract 2497: Does Magnitude of Heart Reduction Influence Clinical Outcomes in Patients with Systolic Chronic Heart Failure Receiving Beta-Blockers? A Regression Analysis of Randomised Controlled Trials
Authors: Genevieve Flannery, Rosie Gehrig-Mills, Baki Billah, Henry Krum
Journal: Circulation (2007)

Background: Beta-blockers (BBs) improve cardiac function and prolong survival in patients with systolic chronic heart failure (CHF). However, the exact mechanisms underlying these benefits are uncertain. Specifically, it is unclear whether a close relationship exists between heart rate (HR) reduction and clinical outcomes with these agents. We therefore tested this hypothesis within randomised controlled trials (RCTs) of BBs in systolic CHF. Methods: Left ventricular ejection fraction (LVEF) and HR values at baseline and end-study were obtained from available BB RCTs. The relationship between change in HR and all-cause mortality as well as LVEF was determined using regression analysis (SPSS). Results: Thirty-six trials, which included 23,122 patients with mean follow-up of 10.5 months, were analysed for all-cause mortality, LVEF and HR. There was a close relationship between all-cause annualised mortality rate and change in HR (adjusted R2=0.51, p=0.004). A strong correlation between change in HR and change in LVEF (adjusted R2=0.47, p=0.000, Figure ) was also observed. When only trials with &gt;100 patients were included, an even tighter relationship was seen (adjusted R2=0.60, p=0.0004). Conclusions: These analyses indicate that a major contributor to the clinical benefits of BB therapy in systolic CHF is the HR-lowering effect of these agents. Therefore, magnitude of HR reduction may be more important than achievement of target dose in BB treatment of systolic CHF.
Community rubella immunization
Authors: R. H. Michaels
Journal: JAMA (1970)

<h3>To the Editor:—</h3> On Sunday, May 17, 1970, a total of 190,845 children received rubella vaccine in Allegheny County, Pennsylvania (Pittsburgh and surrounding communities). Since this probably represents the largest one-day rubella immunization program conducted in the United States to date, some observations made during and following the program may be of interest to those contemplating similar campaigns. The target population was all healthy county residents aged 12 months through 12 years. This age group was selected because it was the one most likely to be susceptible to rubella (and therefore to propagate it in future epidemics) but containing few, if any, females who were presently or soon to be pregnant (for whom the vaccine is not yet proved safe). During the planning stages there was concern that (1) only a small proportion of the target population would come for immunization, (2) boys, because their benefits (no future pregnancy) were
Whiplash Injuries
Authors: James R. Mathews
Journal: JAMA (1963)

<h3>To the Editor:</h3> —Although I do not think the point should be belabored, I would like to point out that Dr. Alexander Gode's description of the<i>coup de lapin</i>(<i>JAMA</i><b>182:</b>1318 [Dec 29] 1962) was not quite exact. For this procedure the rabbit is held by the hind legs, not by the ears. In this head-down position, he conveniently extends his neck as a natural reflex. This letter was referred to Dr. Gode and his reply follows.
The role of computers in medical research
Authors: H. R. Warner
Journal: JAMA (1966)

The purpose of research in medicine is to find new relationships and refine knowledge of already known relationships among the elements which constitute living systems and to find better ways of using this knowledge for prediction and control of the living system. The computer brings to the researcher in almost any phase of medical research a means for amplifying his own powers of observation and insight. It is the purpose of this paper to discuss two of the ways in which computers are presently being used to serve these purposes, namely, on-line data processing and computer simulation of living systems. <h3>Storage, Transformation, and Display of Data</h3> Many new devices have been developed in recent years for the storage and display of information. As a point of reference, consider the strip chart recorder used by most physicians for recording the electrocardiogram. This useful device has limitations, however, in that generally (1)
Author Index Vol. 76, 2007
Authors: Nicoletta Sonino, Giovanni A. Fava, Chantal Henry, Katia M'Baïlara, Rollon Poinsot, Anne-Aurelie Casteret, Frédéric Sorbara, Marion Leboyer, Eduard Vieta, Ludwig Grepmair, Ferdinand Mitterlehner, Thomas Loew, Egon Bachler, Wolfhardt Rother, Marius Nickel, Axel Schweickhardt, Astrid Larisch, Michael Wirsching, Kurt Fritzsche, Carlo Faravelli, Mario Catena, Alessandra Scarpato, Valdo Ricca, Michael Martini Jørgensen, Martin Härter, Harald Baumeister, Katrin Reuter, Frank Jacobi, Michael Höfler, Jürgen Bengel, Hans-Ulrich Wittchen, Robert Zachariae, Axel Skytthe, Kirsten Kyvik, R. Zachariae, K. Paulsen, M. Mehlsen, A.B. Jensen, A. Johansson, H. von der Maase, Fabio Facchinetti, Fedra Ottolini, Marta Fazzio, Marco Rigatelli, Annibale Volpe, Naheed K. Hossain, Jane Irvine, Paul Ritvo, Helen S. Driver, Colin M. Shapiro, Constance Dalenberg, Richard Loewenstein, David Spiegel, Chris Brewin, Ruth Lanius, Steven Frankel, Steven Gold, Bessel Van der Kolk, Daphne Simeon, Eric Vermetten, Lisa Butler, Cheryl Koopman, Christine Courtois, Paul Dell, Ellert Nijenhuis, James Chu, Vedat Sar, Oxana Palesh, Carlos Cuevas, Kelsey Paulson, Harrison G. Pope, Jr., Steven Barry, J. Alexander Bodkin, James Hudson, Carlo Lai, Silvia Daini, Maria Lucia Calcagni, Isabella Bruno, Sergio De Risio, Marco Chiesa, Peter Fonagy, Sabine Loeber, Bernhard Croissant, Helmut Nakovics, Anke Zimmer, Alexander Georgi, Sabine Klein, Carsten Diener, Andreas Heinz, Karl Mann, Herta Flor
Journal: Psychotherapy and Psychosomatics (2007)
Insulin-like growth factor II/mannose 6-phosphate-receptor expression in liver and serum during acute CCl4 intoxication in the rat
Authors: P De Bleser
Journal: Hepatology (1996)

The liver is reported to be the main source of soluble insulin-like growth factor-II/mannose 6-phosphate (IGF-II/M6P) receptor in adults. In view of the role of this receptor in the activation of transforming growth factor β (TGF-β) during hepatic fibrogenesis, we have investigated the correlation between serum levels and tissue expression of the receptor during acute CCl4 intoxication of the rat. Sixteen hours after CCl4, injection, the level of the soluble receptor in serum, as measured by radioimmunoassay (RIA), increased threefold. At 24 hours, values almost returned to normal, but increased again by twofold at 48 hours. By 96 hours, nearly normal values were obtained. Northern blot analysis showed peaks in tissue IGF-II/M6P receptor messenger RNA (mRNA) levels at 24 hours and at 48 hours. In normal liver, immunostaining for IGF-II/M6P receptor showed weak positivity in parenchymal cells. CCl4-induced hydropic changes appeared in centrilobular parenchymal cells (PCs) at 8 hours. These changes extended to the midzonal region at 16 hours. Hydropic cells were devoid of receptor staining. The hydropic wave became extinct at 32 hours. At 48 hours, we observed a collapse of PCs in the centrilobular zone, coinciding with strongly positive staining for IGF-II/M6P receptor in fat-storing cells (FSCs), identified by dual IGF-II/M6P receptor and desmin immunostaining. Between 48 and 72 hours, the liver gradually regained its normal appearance. As shown by Western blotting, in vitro differentiated FSCs released soluble receptor in the medium. Northern blot analysis showed this release to be preceded by an increased receptor-mRNA expression, whereas immunostaining showed an increase of intracellular receptor. In conclusion, we have shown that acute CCl4 intoxication induces two peaks in serum levels of soluble receptor. While the first peak at 16 hours coincides with the loss of receptor- staining in hydropically damaged PCs, the second peak at 48 hours is paralleled by an increase in positive staining in FSCs and tissue mRNA level. Differentiated FSCs shed soluble receptor in vitro. As a consequence, these cells might contribute to the serum levels of soluble receptor in vivo. These results indicate that measuring serum soluble IGF-II/M6P receptor might useful in the diagnosis of early acute liver damage.
Surgical Handicraft. A Manual of Surgical Manipulations, Minor Surgery and other Matters Connected with the Work of House Surgeons and Surgical Dressers.
Authors: None C. E. W.
Journal: JAMA (1885)

This volume will be of value as a book of reference. It treats of a numberless variety of matters coming within the province of the hospital house surgeon and general practitioner. Every man has his own methods and those are best in his hands with which he is most familiar, still suggestions are always useful and amendments always in order. Each reader will probably wish to make some alteration in the book, for it treats of those matters of which every one has practical knowledge. Your reviewer, for instance, would like to suggest that in his experience the incorporation of metallic strips into plaster splints does not add permanent strength to the splint, for it divides it up into layers which make the splint break down quicker than a simple one made of selected plaster. The important point in this connection which is omitted by the author, as well as
Editorial Board
Authors: Sian Lewis, Helen Barbour, Linsey Meredith, Monica Banerjee, Alison Wrigley, Lynne Herndon, Anders Björklund, Sweden Lund, Sarah Paul Bolam, Barry Dickson, John Disterhoft, Chris Doe, Yukiko Goda, Mark Mattson, Richard Morris, Venkateshn Murthy, Maiken Nedergaard, Nancy Rothwell, Mike Shadlen, Colin Akerman, Hollis Cline, Dennis Turner, Kelley Foster, Francesca Galeffi, George Somjen, Markus Heilig, George Koob, Ingo Greger, Edward Ziff, Andrew Penn, Jaideep Bains, Stéphane Oliet, Charlotte Hulst, R Kooy, Yehezkel Ben-Ari, Pascal Fries, Danko Nikolic, Wolf Singer, Ole Jensen, Jochen Kaiser, Jean-Philippe Lachaux, Andrew Maurer, Bruce Mcnaughton, Alain Destexhe, Stuart Hughes, Michelle Rudolph, Vincenzo Crunelli, Edward Mann, Ole Paulsen, John Huguenard, David Mccormick, Constance Hammond, Hagai Bergman, Peter Brown, Michel Le Van Quyen, Anatol Bragin
Journal: Trends in Neurosciences (2007)
Dermatology
Authors: J. S. Dover
Journal: JAMA (1994)

Since 1976, when<i>Propionibacterium acnes</i>was demonstrated to be uniformly sensitive to the antibiotics used in the treatment of acne, an increasing number of patients with antibiotic-resistant propionibacteria have been described. In a recent British study,<sup>1</sup>cultures of propionibacteria were taken from 468 patients with acne. All patients had received courses of antibiotics in the past; 155 patients had acne that was unresponsive to treatment for at least 3 months. Nearly half of the 468 patients had propionibacteria strains that were resistant to one or more antibiotics; erythromycin resistance was most common (124 patients). All 61 patients with propionibacteria strains that were resistant to tetracycline also showed resistance to doxycycline, but none showed resistance to minocycline. Twenty-seven patients had two or more propionibacteria strains with different antibiotic resistances. The patients who showed a response to antibiotics in this study did not harbor antibiotic-resistant propionibacteria strains. To avoid the problem
Insulin and glucagon infusion in acute alcoholic hepatitis: A prospective randomized controlled trial
Authors: G Bird
Journal: Hepatology (1991)

In a randomized, controlled trial to investigate the possible benefit of insulin and glucagon therapy in severe acute alcoholic hepatitis, 86 patients were randomized to receive 30 U insulin and 3 mg glucagon in 250 ml 5% dextrose over 12 hr each day for 3 wk or a similar regime of identical placebo. No significant differences were seen in patients' clinical characteristics and disease severity in the treated and placebo groups. Of the 43 patients receiving insulin and glucagon, 15 (35%) died within 4 wk of randomization, compared with 14 deaths (33%) in the control patients (p = not significant). When the patients surviving the first 4 wk were examined there were five more deaths in the treatment group, compared with one death in the control group at 6-mo follow-up (p = not significant). No significant differences in the frequency of short-term or long-term complications of alcoholic liver disease or relapse to alcohol were seen when the two groups were compared, although hypoglycemia was seen in six patients during infusion of insulin and glucagon. Similarly, no significant differences were seen in the improvement in clinical or biochemical features at 4 wk and at 6 mo in survivors when the insulin and glucagon–treated patients were compared with patients in the placebo group. This study does not confirm previous reports that insulin and glucagon infusion improves the outcome of severe acute alcoholic hepatitis. (HEPATOLOGY 1991;14:1097–1101.)
Poetry and Medicine
Authors: Albert Howard Carter
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Update in Hepatology
Authors: Eugene R. Schiff
Journal: Annals of Internal Medicine (1999)

Updates5 January 1999Update in HepatologyEugene R. Schiff, MDEugene R. Schiff, MDFrom University of Miami School of Medicine, Miami, Florida.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-1-199901050-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Many topics related to hepatology gained attention in 1997, but the areas that currently warrant note here are viral hepatitis, other types of liver disease, complications of cirrhosis, and liver transplantation. Better understanding of clinical pathways in all of these areas has led to an increased ability to manage problems that arise in hepatology.Hepatitis B VirusPatients with chronic hepatitis B have persistence of hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and hepatitis B virus (HBV) DNA in their serum. These patients harbor replicating virus and have histologic evidence of ongoing chronic hepatitis.At a minimum, ... Author, Article, and Disclosure InformationAuthors: Eugene R. Schiff, MDAffiliations: From University of Miami School of Medicine, Miami, Florida.Corresponding Author: Eugene R. Schiff, MD, Division of Hepatology, Center for Liver Diseases, University of Miami School of Medicine, 1500 NW 15th Avenue, Suite 1101, Miami, FL 33136.Current Author Address: Dr. Schiff: Division of Hepatology, Center for Liver Diseases, University of Miami School of Medicine, 1500 NW 12th Avenue, Suite 1101, Miami, FL 33136. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitisSomatic Comorbidity of Addicts 5 January 1999Volume 130, Issue 1Page: 52-57KeywordsCirrhosisGastroenterology and hepatologyHepatitisHepatitis BInfectious hepatitisInterferonsLiver diseasesLiver transplantationSuicideTransplantation ePublished: 15 August 2000 Issue Published: 5 January 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Iatrogenic Renal Hypertension:
Authors: C. Hilmon Castle
Journal: JAMA (1973)

Two young men with familial extra-adrenal pheochromocytoma (paraganglioma) had almost identical tumors removed with similar postoperative courses, complicated by development of other causes of hypertension. Renal ischemia and persistent blood pressure elevation occurred in both patients but were caused by different anatomic defects. One developed retroperitoneal fibrosis that gradually obstructed renal blood flow to the right kidney; the second patient had a small aberrant artery to the inferior pole of the kidney ligated with prompt development of hypertension. Nephrectomy was necessary in the first patient; segmental resection of the ischemic portion of the kidney was sufficient to interrupt the renin-angiotensin system and allow the blood pressure to return to normal in the second patient.
Multi-istitutional study of the evaluation of eribulin (E) use in Sicily in metastatic breast cancer (MBC): A prospective registry (VESPRY trial).
Authors: Vincenzo Adamo, Giuseppina Rosaria Rita Ricciardi, Veronica Franchina, Giuseppa Ferraro, Michele Caruso, Giuseppe Bronte, Giuseppe Luigi Banna, Pietro Spadaro, Antonino Savarino, Carmelo Iacono, Hector J. Soto Parra, Massimiliano Spada, Valentina Safina, Livio Blasi, Filippo Zerilli, Angela Prestifilippo, Carmelo Giannitto-Giorgio, Davide Alberio, Lorenzo Cottini, Antonio Russo
Journal: Journal of Clinical Oncology (2015)

e12023 Background: Eribulin mesylate is a non taxane microtubule dynamics inhibitor and represents a novel chemotherapeutic agent for the treatment of MBC. Methods: This is an ongoing, open-label, multicenter, prospective, post-marketing observational, single arm study of the use of E for the treatment of third line of patients (pts) with heavily pretreated locally advanced or metastatic breast cancer. This study was conducted in 14 oncology centers in the Southern Italy. This trial will enroll 120 pts and will receive, after two lines of chemotherapy for MBC, at least one dose of E at 1.23 mg/m2 on days 1 and 8 of every 21-day cycle. Pts will receive E until progression. A population analysis of 120 patients will ensure a precision deemed sufficient for the estimation of the confidence interval at 95% of the percentage of pts with severe neutropenia (grade 3-4), expected to be around 45% in this population. Primary Endpoints: safety profile of the Eribulin and response according to the site of metastases. Secondary Endpoint: evaluation of response according to different subtypes of breast cancer. Results: At the time of this analysis 60 pts were collected. Median age 59 (range 29-78). All pts received previously anthracycline and taxane based therapy. Subtypes: Luminal A 78%, Luminal B 6%, HER2 enriched 6% and Triple Negative 10%. The main site of metastases was: lung 45%, bone 37% and liver 25%. A median of 4 cycles of Eribulin (range 1-13) was administred. Acceptable and manageable safety toxicity profile was recorded (G1-G2 neutropenia, neurotoxicity, diarrhea, asthenia). We reported only one case G4 mucositis, leading to treatment interruption. Overall response rate was 17% (all Partial Response) and Stable Disease 57%. We performed an organ-specific analysis that revealed an higher rate of stabilization in the lung lesions compared to other site of metastases (lung 82%, liver 60% and brain 63%). The estimated median Time to Progression was 4 months (range 1-9). Conclusions: This preliminary analysis confirmed Eribulin efficacy and favourable safety profile in third line setting in our population, with results comparable to that reported in the registrative trial (Cortes J, 2011).
The neuroanatomical ultrastructure and function of a biological ring attractor
Authors: Daniel B. Turner-Evans, Kristopher T. Jensen, Saba Ali, Tyler Paterson, Arlo Sheridan, Robert P. Ray, Tanya Wolff, J. Scott Lauritzen, Gerald M. Rubin, Davi D. Bock, Vivek Jayaraman
Journal: Neuron (2021)