tbuckley/cabot-search huggingface dataset:
Measurement of Nicotine in Building Air as an Indicator of Tobacco Smoke Levels
Authors: Don C. Williams, John R. Whitaker, Walter G. Jennings
Journal: Environmental Health Perspectives (1985)

Humans apparently differ greatly in their sensitivity and tolerance to tobacco smoke, thereby creating conflicts in the workplace. Resolution of conflicts in a large office complex at the authors' institution required an objective measure of smoke levels. A gas chromatographic technique was devised for collection and analysis of nicotine concentrations in the building air as an indicator of tobacco smoke pollution. Segregation of smokers and nonsmokers in the large office complex still resulted in substantial exposure of the nonsmoker to tobacco smoke, although a gradient of exposure was certainly observed. Passive tobacco smoke consumption in the smoking area of the office complex was calculated to be equivalent to 1.1 cigarettes per 8-hr period, and nicotine density in this area was 1.96 microgram/m. The restriction of smoking to a foyer area outside the office complex resulted in a slow but eventual reduction in nicotine concentrations in the office complex. Observed "background" nicotine concentration levels corresponding to 4 to 7% of those encountered in smoking areas demonstrate that central air circulation systems and people movement increase the nicotine level throughout all rooms of a building, regardless of the smoking policies of an individual office complex. Recent documentation of the relationship between passive smoking and cancer, heart disease, pulmonary dysfunction, and allergic responses argues for restriction of smoking to building exteriors.
LITHOLAPAXY AND A NEW LITHOTRITE.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Remembering Our Predecessors
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Cost of surfactant replacement treatment for severe neonatal respiratory distress syndrome
Authors: Thomas Lynch, Brian Waymont, Christopher Beacock, J Dunn, Michael Hughes, Michael Wallace, Mr Lynch
Journal: BMJ (1991)

About 31 000 transurethral prostatectomies are per- formed in England annually.'We carried out a prospective study of 111 consecutive patients undergoing transurethral resection of the prostate for benign hyperplasia to determine the need for routine follow up after surgery.The value of a routine outpatient visit has not previously been examined.
Visuospatial Processing and the Function of Prefrontal-Parietal Networks in Autism Spectrum Disorders: A Functional MRI Study
Authors: Timothy Silk
Journal: American Journal of Psychiatry (2006)

Objective: Individuals with autism spectrum disorders typically have normal visuospatial abilities but impaired executive functioning, particularly in abilities related to working memory and attention. The aim of this study was to elucidate the functioning of frontoparietal networks underlying spatial working memory processes during mental rotation in persons with autism spectrum disorders. Method: Seven adolescent males with normal IQ with an autism spectrum disorder and nine age- and IQ-matched male comparison subjects underwent functional magnetic resonance imaging scans while performing a mental rotation task. Results: The autism spectrum disorders group showed less activation in lateral and medial premotor cortex, dorsolateral prefrontal cortex, anterior cingulate gyrus, and caudate nucleus. Conclusions: The finding of less activation in prefrontal regions but not in parietal regions supports a model of dysfunction of frontostriatal networks in autism spectrum disorders.
Manuscript Reviewers
Authors: DAVID H. SPODICK
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 October 1972Manuscript ReviewersDAVID H. SPODICK, M.D.DAVID H. SPODICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-4-663_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Although I agree with Dr. Huth's reservation, Dr. Harry Abram (Ann Intern Med 77:153-154, 1972) has courageously tackled one of many ethical considerations for manuscript reviewers. To judge whether other persons' work will see the light of day should involve the most unwavering impartiality allotment of sufficient time for careful reading and reference, and speediest report consistent with fair judicial process. Unfortunately, some or all such criteria (indeed, such moral obligations), particularly the last, are not always assumed by journal reviewers.An adverse judgment, particularly, from the ethical reviewer calls for the highest standards, the most painstaking... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID H. SPODICK, M.D.Affiliations: Department of Medicine Lemuel Shattuck Hospital Tufts University School of Medicine Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byJOURNAL REFEREES' REPORTS 1 October 1972Volume 77, Issue 4Page: 663-663 ePublished: 1 December 2008 Issue Published: 1 October 1972 PDF downloadLoading ...
Hypnosis may reduce hemophiliacs' blood needs
Authors: J. Martin
Journal: JAMA (1983)

For many Americans needing blood transfusions or blood products, the specter of acquired immune deficiency syndrome (AIDS) is casting a sinister shadow over a life-sustaining procedure. For example, 18 cases of AIDS have been reported in hemophiliacs, with 12 deaths, since March 1982, according to the Centers for Disease Control. Now a Denver physician is saying that one immediately available means of countering the threat is to make blood products less necessary for hemophiliacs. "And that can be done by teaching hemophiliacs self-hypnosis which, by reducing anxiety, can reduce their needs for remedial transfusions," says Wallace L. LaBaw, MD. LaBaw and his wife, Jeanine L. LaBaw, PsyD, have been teaching self-hypnosis to hemophiliacs since 1968. "With hypnosis, you can cut the need for transfusion by up to 50% in some patients," say the LaBaws (<i>J Haematologia</i>1975;9:103-110). The AIDS peril is not being taken lightly by the National Hemophilia Foundation,
References and Reviews
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 757: MiR-141-3p is upregulated in esophageal squamous cell carcinoma and targets pleckstrin homology domain leucine-rich repeat protein phosphatase-2, a negative regulator of the PI3K/AKT pathway
Authors: Ichiro Akagi, Osamu Ishibashi, Yota Ogawa, Toshihiro Takizawa
Journal: Cancer Research (2019)

Abstract The phosphatidylinositol-3-kinase (PI3K)/AKT pathway is frequently activated in various human cancers and plays essential roles in their development and progression. Accumulating evidence suggests thatdysregulated expression of microRNAs (miRNAs) is closely associated with cancer progression and metastasis. Here, we focused on miRNAs that could regulate genes related to the PI3K/AKT pathway inesophageal squamous cell carcinoma (ESCC).To identify upregulated miRNAs and their possible target genes in ESCC, we performed microarraybased integrative analyses of miRNA and mRNA expression levels in three human ESCC cell lines and a normal esophageal epithelial cell line. The miRNA microarray analysis revealed that miR-31-5p, miR-141-3p, miR-200b-3p, miR-200c-3p, and miR-205-5p were expressed at higher levels in the ESCC cell linesthan the normal esophageal epithelial cell line. Bioinformatical analyses of mRNA microarray data identified several AKT/PI3K pathway-related genes as candidate targets of these miRNAs, which include tumor suppressors such as DNA-damage-inducible transcript 4 and pleckstrin homology domain leucine-rich repeat protein phosphatase-2 (PHLPP2). To validate the targets of relevant miRNAs experimentally, synthetic mimics of the miRNAs were transfected into the esophageal epithelial cell line. Here, we report that miR-141-3p suppress the expression of PHLPP2, a negative regulators of the AKT/PI3K pathway, as a target in ESCC. Note: This abstract was not presented at the meeting. Citation Format: Ichiro Akagi, Osamu Ishibashi, Yota Ogawa, Toshihiro Takizawa. MiR-141-3p is upregulated in esophageal squamous cell carcinoma and targets pleckstrin homology domain leucine-rich repeat protein phosphatase-2, a negative regulator of the PI3K/AKT pathway [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 757.
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
Authors: Hong-guang Xia, Ayaz Najafov, Jiefei Geng, Lorena Galan-Acosta, Xuemei Han, Yuan Guo, Bing Shan, Yaoyang Zhang, Erik Norberg, Tao Zhang, Lifeng Pan, Junli Liu, Jonathan L. Coloff, Dimitry Ofengeim, Hong Zhu, Kejia Wu, Yu Cai, John R. Yates, Zhengjiang Zhu, Junying Yuan, Helin Vakifahmetoglu-Norberg
Journal: The Journal of Experimental Medicine (2015)
Missing Authorship, Incorrect Date.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Economics of coronary artery bypass grafting
Authors: A. Williams
Journal: BMJ (1985)

<h3>Background</h3> Psoriasis (Pso) and psoriatic arthritis (PsA) are chronic and disabling inflammatory diseases, characterized by a chronic-relapsing and unpredictable course. Traditional systemic therapies for these conditions are limited by lack of efficacy and potential toxicity, expecially in the long-term disease management. <h3>Objectives</h3> The present retrospective study aimed to evaluate the long-term efficacy and safety profile of subcutaneous anti-TNF agents, etanercept and adalimumab, in elderly patients (aged over 65 years) affected by PsO and PsA, including patients with comorbidities. <h3>Methods</h3> The study included 89 patients aged more than 65 years affected by plaque-type psoriasis (27) and psoriatic arthritis (62) that received subcutaneous anti-TNF alpha agents, etanercept (61) and adalimumab (28) as monotherapy for a long-term treatment period, lasting more than 52 weeks. <h3>Results</h3> Efficacy results were consistent as expressed by the percentage of patients who achieved and maintained PASI75 and by the improvement of articular severity indexes [pain visual analogic scale (Pain VAS) and DAS44]. Indeed, safety profile of treatment was good considering the consistent prevalence of cardiovascular and metabolic comorbidities and the long-term treatment duration. During the long-term treatment period, treatment adherence was consistent particularly for patients undergoing to etanercept, in fact among 61 patients only 15 (24.59%) treatment withdrawal were registered, while among 28 patients treated with adalimumab 11 (39.28%) treatment withdrawal were recorded. The survival rate after 3 years of treatment was 75.40% and 60.71%, for etanercept and adalimumab study population, respectively. <h3>Conclusions</h3> Recent studies have demonstrated that PsO and PsA are associated with systemic disorders that might be sharing the same inflammatory pathway including, type 2 diabetes, obesity, hypertension, dyslipidaemia, metabolic syndrome, as well as cardiovascular disease and atherosclerosis. In elderly patients, the identification and prevention of associated risk factors as well as the systemic control of inflammation in psoriasis could result in the additional improvement of the underlying conditions. Our study demonstrated that subcutaneous anti-TNF alpha agents resulted effective in the long-term course showing an optimal safety profile considering the peculiar characteristics of patients over 65 years. The results of the present study indicate that etanercept and adalimumab may represent a valid, effective and safe therapeutic alternative even in presence of major health problems in elderly patients. <h3>References</h3> Krueger G, Koo J, Lebwohl M et al. The impact of psoriasis on quality of life; results of a 1998 National Psoriasis Foundation patient-membership survey. Arch Dermatol 2001; 137: 280–284 Risk factors of hypertension, diabetes and obesity in Italian psoriasis patients: a survey on socio-demographic characteristics, smoking habits and alcohol consumption. <h3>Disclosure of Interest</h3> None Declared
RESPIRATION AND THE CARBON DIOXID CAPACITY OF THE BLOOD
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemorrhage from abdominal non‐Hodgkin's lymphoma treated successfully by emergency transcatheter arterial embolization
Authors: Junji Suzumiya, Mitsuyuki Nagano, Hideyuki Higashihara, Tetsuya Yoshida, Motoi Hirano, Yoshinori Go, Eiji Morioka, Nobuhiro Kimura, Shusuke Hisano, Masatoshi Okazaki, Masahiro Kikuchi, Makoto Okumura
Journal: American Journal of Hematology (1996)

A 49-year-old Japanese woman with follicular lymphoma who presented with severe abdominal and back pain is reported. She was known to have malignant lymphoma and had been previously treated with combination chemotherapy. An abdominal tumor occurring at the root of the mesentery and involving the superior mesenteric artery (SMA) had been diagnosed by computed tomography (CT), magnetic resonance imaging, and abdominal angiography. Emergent ultrasonography and CT findings showed intraperitoneal bleeding from the abdominal tumor. Selective SMA angiography revealed extravasation from a small branch originating from the dorsal pancreatic artery, which was embolized through a catheter by using platinum coils. It should be noted that a large tumor of malignant lymphoma, involving large vessels, may bleed, and in such a case selective transcatheter arterial embolization may be one of the effective modalities for hemostasis. © 1996 Wiley-Liss, Inc.
Editorial Board
Authors: Zuhair Ballas, Iowa City, Iowa Deputy, David Huston, Rachel Miller, New York, N Associate, Andrea Apter, Leonard Philadelphia, St Bacharier, Claus Louis, Joshua Bachert, Boston Boyce, Robert Bush, Javier Chinen, Raif Geha, Corinne Keet, Carole Ober, David Peden, Harald Renz, Marburg Germany, Marc Rothenberg, Cincinnati Ohio, Hirohisa Saito, Tokyo Japan, Stephan Weidinger, Bruce Bender, Pascal Chanez, Morton Cowan, San Francisco, Elizabeth Matsui, Peter Arkwright, Arthur Gelb, Los Angeles, Akio Mori, Harry Schroeder, Birmingham Ala, Jonathan Spergel, Julie Wang, Eric Brandt, Emma Guttman-Yassky, Hirohito Kita, Tanya Laidlaw
Journal: Journal of Allergy and Clinical Immunology (2020)
Phase II Trial of Intravesical Gemcitabine in Bacille Calmette-Guérin–Refractory Transitional Cell Carcinoma of the Bladder
Authors: Guido Dalbagni, Paul Russo, Bernard Bochner, Leah Ben-Porat, Joel Sheinfeld, Pramod Sogani, Machelle S. Donat, Harry W. Herr, Dean Bajorin
Journal: Journal of Clinical Oncology (2006)

Purpose The aim of this phase II study was to determine the efficacy of gemcitabine administered as an intravesical agent in patients with bacille Calmette-Guérin (BCG) –refractory transitional cell carcinoma of the bladder. Patients and Methods Patients with superficial bladder cancer refractory or intolerant to intravesical BCG therapy and refusing a cystectomy were considered eligible for the trial. Eligible patients received two courses of intravesical gemcitabine twice weekly at a dose of 2,000 mg/100 mL for 3 consecutive weeks, with each course separated by 1 week of rest. Patients were evaluated for response at 8 weeks, then every 3 months to 1 year. Results Thirty eligible patients were included on study. The median follow-up for all the patients was 19 months (range, 0 to 35 months). Of the 30 patients, 15 (50%; 95% CI, 32% to 68%) achieved a complete response (CR). Twelve patients had tumor recurrence with a median recurrence-free survival time of 3.6 months (95% CI, 2.9 to 11.0 months). Two patients maintained a CR at 23 and 29 months, respectively. The 1-year recurrence-free survival rate for patients with a CR was 21% (95% CI, 0% to 43%). Two patients progressed to a higher stage while receiving gemcitabine treatment. The median follow-up for patients who did not have a progression or a cystectomy was 19 months (range, 2 to 35 months). Eleven patients (37%) underwent a cystectomy subsequent to gemcitabine therapy. Conclusion Gemcitabine has activity in a high-risk patient population and remains a viable option for some patients who refuse cystectomy.
Syphilis
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal