tbuckley/cabot-search huggingface dataset:
D/D angiotensin converting enzyme genotype increases target vessel revascularization in diabetic patients Kimberly A. Skelding, Demetris Demetriou, Laxmi Mehta, Mark C. Pica, Domnita Crisan, Debra A. Guido-Allen, Judith A. Boura, Bohuslav Finta, Robert D. Safian, James A. Goldstein, Cindy L. Grines, William W. O'Neill. William Beaumont Hospital, Royal Oak, MI
Journal: Journal of the American College of Cardiology (2001)
QUININ AND IRON IN PNEUMONIA.
Authors: CHARLES F. NIEDER
Journal: JAMA (1906)

The satisfactory results noted in my previous report<sup>1</sup>of pneumonia cases treated by quinin and iron have continued. My experience with this method is limited to 15 cases. The only fatal case was that of a pronounced alcoholic who had been suffering for months with an active tuberculous process in both lungs. He had been unable to work for two months prior to the attack of pneumonia. In this case the treatment exerted a beneficial influence on the circulation. The patient was nearly pulseless on the second day of the disease before instituting treatment. After administering the quinin and iron a good pulse was maintained for five days. In response to requests which are being made for more information concerning the quinin and iron treatment of pneumonia, I submit the following report of a recent case: <h3>Patient.</h3> —J. McC., aged 30, maltster. <h3>History.</h3> —The patient had never been ill
Unusual Stroke Risk Factors Reported at ASA Conference
Authors: M. Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhanced G-protein-induced relaxation in portal hypertensive rats: Role of nitric oxide
Authors: M Hou
Journal: Hepatology (1997)

Portal hypertension (PHT) is characterized by splanchnic hyperemia due to a reduction in mesenteric vascular resistance. The reasons for the decreased resistance include an increased responsiveness to a vasodilator substance. Because the activation of an inhibitory guanine nucleotide regulatory (Gi) protein can result in endothelium-dependent relaxation, we tested the hypothesis that exaggerated Gi-protein induced relaxation via a nitric oxide (NO)-dependent pathway partly reflects the enhanced Gi-protein expression in PHT vessels. PHT was created in Sprague-Dawley rats by a partial portal-vein ligation. Control animals were sham operated. Using isolated vascular rings in the absence or presence of an intact endothelium, NG-nitro-L-arginine methyl ester (L-NAME), and pertussis toxin, dose response relationships for sodium fluoride (NaF; range, 0.1–4 mmol/L), a Gi protein activator, were determined in a cumulative manner. Gi-protein expression was determined by Western blotting. NaF caused a dose-dependent relaxation in both sham and portal hypertensive pre-contracted vessels, an effect that was significantly inhibited by pertussis toxin, endothelial denudation, and L-NAME. Concentrations of NaF greater than 4 mmol/L caused contractions, an effect that was unaffected by L-NAME. The NaF-induced relaxation response was significantly greater in PHT vessels as compared with sham concomitant with increased Gi-protein expression in PHT vessels. These data suggest that the enhanced endothelial Gi-protein-induced relaxation in PHT vessels may partly reflect enhanced expression of Gi-proteins in PHT vessels and may, thus, represent an important mechanism for exaggerated NO-dependent relaxation in the PHT vasculature.
Outcomes of immunotherapy administration for hospitalized cancer patients.
Authors: David W. Dougherty, Houry Leblebjian, Megan Duperrault, Mark M. Awad, Sylvia Bartel, Anne McDonnell, Craig A. Bunnell, Andrew J. Wagner, Chintan Pandya, Lauren M. Hamel, Brett Glotzbecker
Journal: Journal of Clinical Oncology (2019)

98 Background: With approvals across multiple cancer types and favorable toxicity profiles, oncologists may consider using immunotherapy (IMT) while their patients are hospitalized. Inpatient IMT may be cost-prohibitive to administer for most institutions due to high cost and inpatient payment structure, but little data are available to evaluate outcomes for IMT in hospitalized patients. We investigated the survival benefit of administering IMT to hospitalized patients with cancer at an NCI-designated cancer center. Methods: We conducted a retrospective chart review of all patients receiving ipilimumab, nivolumab, or pembrolizumab during inpatient admission at Dana-Farber Cancer Institute/Brigham &amp; Women’s Hospital in 2017. For each patient, we assessed: total dose, indication for dosing, cancer type, time between dose and discharge, time between discharge and death, and total cost (average wholesale price). Study follow up was January 1, 2017 to July 1, 2018. Results: Fifty doses of IMT were administered to 44 patients. Most patients (40) received 1 dose, 2 patients received 3 doses, 1 patient received 2 doses, and 1 patient received a combination of ipilimumab/nivolumab. The most common cancer types were lung (41%), gastrointestinal (18%), and head and neck (16%). Indications for IMT administration were: patient due for next dose (48%), disease progression (42%), and new diagnosis (11%). The majority of doses (70%) were received within 7 days prior to discharge, with 32% of doses within 1 day of discharge. The majority of patients (86%) died in the study period; 14% of patients died during admission. Average survival between discharge and death was 54 days (range: 0-444 days). Total cost of inpatient IMT administration was $413,370, an average of $9,395 per patient. Conclusions: To our knowledge, this is the largest analysis of outcomes for patients receiving IMT during a hospitalization. Inpatient use of IMT in cancer patients is associated with high cost and poor clinical outcomes. Dosing within one week prior to hospital discharge was common. Clinical factors such as PD-L1 status, disease status, and reason for admission, which may be important to understand which patients may benefit most from inpatient IMT, should be examined.
This is medical progress? Trends and consequences of antibiotic use in the United States
Authors: H. E. Simmons
Journal: JAMA (1974)

SINCE the first antibiotic, penicillin G, was marketed in the United States in 1943, these useful and potent antimicrobial agents have been widely adopted and used in the ensuing 30 years. The purpose of this article is to review the trends of antibiotic usage in the United States and try to assess the consequences of the remarkable popularity of this class of drugs. While the value and medical usefulness of appropriate antibiotic employment in clinical practice is unquestioned, there has been a considerable controversy over both the type and extent of antibiotic prescribing and the proper indications for use. Furthermore, the ecologic consequences of this wide usage are still unclear. The following are some of the issues: Has the wide use of antibiotics led to the emergence of new resistant bacterial strains? Has the ecology of "natural" or "hospital" bacterial flora been shifted because of antibiotic use? Has the ecology of
Socioeconomic conditions and ischaemic heart disease.
Journal: BMJ (1991)

in 20 000 live births and this includes both familial and non-familial cases.There were 1068 children born in Seascale between 1950 and 1983.2There would have to be a 20-fold increase in incidence before a single case was expected in this population.It is nonsense to state that retinoblastoma should be "generally more common in Seascale."Similar arguments apply to Millom rural district.It is the extreme rarity of retinoblastoma that makes the observation of five cases linked to Seascale so extraordinary and noteworthy.The ideas in our paper are neither confusing nor contradictory.The data, in fact, strongly suggest a link between retinoblastoma and residence in Seascale.The nature of the association remains to be determined, but it is wrong to imply that radiation can be excluded as the causative agent.
An Address Delivered at the Opening of the Section of Medicine
Authors: E. L. Fox
Journal: BMJ (1881)

TMOXON, in the Croonian lectures of the present year, quotesProfessor Virchow to the effect that "we are not to look to the vessels for the initiative in diseases of the textures of the body; that the life of texture is in the texture itself-its pathological as well as its natural life; and that the movements of the blood, in what is called irritative or inflammatory congestion, are secondary to a demand upon the blood and blood-vessels, which demand is made by the proper power of the textural elements."W\Tith a full recognition of this truth, the health of a tissue must largely depend on a normal condition of the blood on which this demand is made, and on a healthy state of the vessels through which the demand is supplied.To this line of thought, in connection with the nerve-centres, I invite attention for a few moments.Taking gout as a starting-point, I put on one side the lately revived suggestion, that the origin of gout lies primarily in a morbid state of the nervous system.Much may be said in favour of this view; whilst, on the contrary, it is difficult to prove that this impaired condition of the nervous centres produces this effect, except in persons hereditarily vulnerable to gout.But our subject is almost the converse of this.Given gout, on what do the nerve-phenomena, that may manifest themselves in a gouty person, depend?At our annual meeting, held in Manchester in I879, Dr. Russell Reynolds sums up the nerve-phenomena that he himself had recognised as occurring with and from gout.I. Mental disturbances, such as restlessness, insomnia, hysteria, failing memory, want of power of attention, suicidal thoughts, intense melancholy. 2.Pain in the head, of very varied intensity, especially unilateral pain, usually parietal or occipital, forced into almost intolerable severity by movement, and without tenderness of scalp, and not aggravated by mental exertion.
Correction: Pharmacokinetics of Anti-CEA scFv-Fc and Variants: Table 1.
Journal: Cancer Research (2007)

In the article on pharmacokinetics of anti-CEA scFv-Fc and variants in the January 15, 2005 issue of Cancer Research (1), there are three errors in Table 1. In the first line under 131I-scFv-Fc I253A (Blood), the value under the fifth column (6 hours) should be 22.5 (0.54); in the first line under 125I-scFv-Fc H310A (Blood), the value under the fourth column (4 hours) should be 25.0 (0.74); and in the first line under 131I-scFv-Fc H310A/H435Q (Blood), the value under the sixth column (12 hours) should be 10.7 (0.46). The corrected Table appears below.
Preoperative pulmonary evaluation and therapy for surgery patients
Authors: M. Stein
Journal: JAMA (1970)

Simple pulmonary function studies can be utilized successfully for diagnosis of pulmonary problems in surgery patients preoperatively. In the present study, randomly selected "poor risk" patients were treated preoperatively and postoperatively with cessation of smoking, bronchodilator drugs, antibiotics, inhalation of humidified gases, segmental postural drainage, and chest physiotherapy. When compared to nontreated poor risk patients, the treated patients had a marked reduction in postoperative morbidity and mortality due to pulmonary complications. Although the frequency and the severity of pulmonary complications were somewhat greater in the treated patients than in a group of "good risk" patients who were considerably younger in age, the differences were not significant. Extension of these simple therapeutic measures to large numbers of poor risk patients should reduce postoperative morbidity and mortality, allow earlier discharge, and lower the costs of patient care.
Retraction of “MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance”
Authors: Jinping Lu, Yuejin Li, Yuanzhong Wu, Shan Zhou, Chaojun Duan, Zigang Dong, Tiebang Kang, Faqing Tang
Journal: Theranostics (2020)

The Editor-In-Chief of Theranostics, in consultation and agreement with the editorial board members, retracts the article "MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance" [1] on the basis of questions related to several figures.The concerns about the figures also raise questions about the conclusions within the paper.
Penicillin treatment for congenital syphilis. A critical reappraisal
Authors: G. H. McCracken
Journal: JAMA (1974)

The asymptomatic infant with suspected congenital neurosyphilis poses a diagnostic and therapeutic problem. Because cerebrospinal fluid serologic studies may be falsely reactive, the clinician is frequently forced to treat infants as if they have neurosyphilis despite the lack of confirmatory laboratory data. There are very few clinical studies to indicate the proper dosage and preparation of penicillin for treatment of congenital syphilis. The current recommendations for treatment make no distinction for infants with or without neurosyphilis. Revised treatment schedules for congenital syphilis with or without central nervous system disease are proposed in accordance with the available pharmacologic data and in the absence of adequate clinical experience. (<i>JAMA</i>228:855-858, 1974)
Endometriosis.
Authors: E J Thomas
Journal: BMJ (1993)

encourage more people to take an overdose.It should, however, reduce the likelihood of an accidental overdose being taken from severe pain and increase the chance that if a patient's family knows of the overdose they will encourage him or her to seek prompt medical advice.The pharmaceutical industry is in a pivotal position to address the problem of the continuing high mortality from paracetamol overdose as the addition of an antidote, such as methionine, to all available preparations might prevent every death that currently occurs.At present paracetamol- methionine combinations are costly, little publicised, and rarely prescribed.Adding methionine to all preparations of paracetamol might increase prices and therefore reduce sales.Another solution might be to develop non-hepatotoxic derivatives of paracetamol.It will indeed be tragic if the mortality from paracetamol overdose over the next quarter of a century proves to be as high as that of the last.
A new look at hospital clinical privileges as they apply to radiology
Authors: H. A. Baltaxe
Journal: JAMA (1983)

THE HOSPITAL medical staff has the overall professional responsibility for the quality of all medical care provided to patients and for the ethical conduct and professional practices of its members. It must be accountable to the governing body, which, by virtue of applicable statutes, regulations, and judicial decisions, bears ultimate legal responsibility for the quality of care provided in the hospital. One of the greatest concerns of an industrial society is the establishment of quality-assurance programs, which when lacking may be the primary cause for its downfall. Industry is spending what seems to be a large amount of time and money on quality-assurance programs such as passenger safety by the airline industry. The health industry cannot and should not deviate from this direction; it has to institute quality-assurance programs for patient safety. The hospital must demonstrate a consistent endeavor to provide patient care that is optimal within available resources and
Immunologic Aspects of Diseases of the Eye
Authors: Mitchell H. Friedlaender
Journal: JAMA (1987)

THE EYE may be the target of allergic inflammation in a variety of systemic immunologic conditions. Ocular signs and symptoms can often be the most striking and disabling aspects of such diseases. The eye also is affected by several local conditions in which immunologic mechanisms are thought to play a significant role. Major structures of the eye are illustrated in Fig 10-1. Immunologically mediated diseases of the skin and mucous membranes, the cornea, and the uveal tract and retina are discussed in the following sections. <h3>DISEASES OF THE SKIN AND MUCOUS MEMBRANES OF THE EYE Allergic Conjunctivitis</h3> Many patients with allergic rhinitis have red, itchy, watery eyes. This form of conjunctivitis, known simply as<i>allergic conjunctivitis</i>, is an IgE-mediated reaction in which conjunctival mast cells participate. As in allergic rhinitis, preformed mediators such as histamine are released from mast-cell cytoplasmic granules while arachidonic acid metabolites (prostaglandins and leukotrienes) are synthesized
TBLR1 Fuses To Retinoid Acid Receptor Alpha In a Variant t(3;17)(q26;q21) Translocation Of Acute Promyelocytic Leukemia
Authors: Yirui Chen, Shouyun Li, Chunlin Zhou, Jiawei Zhao, Haiyan Xing, Zheng Tian, Kejing Tang, Yingchang Mi, Qing Rao, Min Wang, Jianxiang Wang
Journal: Blood (2013)
Erratum
Authors: Julv Final, -P Sullivan, -J Stewart, Examiiination.-A Curry, C Daniell, E Evans, P Ferguson, P Gaffney, M Harrington, D Hawkshaw, H Hurley, T Kay, P Lyons, K Maguire, P Murray, E O'hagan, B Ryan, A Wallace, J Warnock, S Blake, H Burbidge, C Burton, G Caldwell, H Carden, P Cusack, E Elvery, J Gilligan, R Hanafin, E Herrick, F Loughnan, J Morris, P Molyneux, C Murray, D Murphy, J Mcoormack, W O'connell, H O'farrell, T Raverty, R Sheehy, H Ballantyne, L Bianchi, J Jardine, P Harry, F Keisler, K Moody-Stuart, R Vansomeren, M Sufi, J Sutton, D Williams, R Cunningham, A Macgregor, G Wight, W Simpson, J Hmunsiff, F Larkins, E Burnett, P Clarke, I Clifford, E Dawson, H Down, T Fletcher, R Green, E Harty, W Hynes, G Kelty, P Lyon, T Mcfarlan, L Myles, T Ross, H Scott, B Taylor, E Watson, T Williams, Watson Charles, Surgery.-*'if Powell, Te Watts, Tp West, -Tg Biggs, W Cable, M Dollie, Tjp Vawdrey, Mlidwifery.-R Evans, F Macphail, J Meynell, F O'dowd, C Spencer, J Wilson, Messrs Biggs, P Vawdrey, E Watts, P West
Journal: BMJ (1905)
A Report on the Biliary Secretion of the Dog; with Reference to the Action of Cholagogues
Authors: W. Rutherford
Journal: BMJ (1878)

IN the first series of these experiments, published in this JOURNAL in 1875, an account was given of the action of podophyllin, colchicum, rhubarb, aloes, scammony, calomel, taraxacum, senna, gamboge, croton, and castor-oil, on the biliary secretion of the dog.The account of the second series, published in this JOURNAL in I877, contained the results of similar experiments with euonymin, sanguinarin, iridin, leptandria, ipecacuan, colocynth, jalap, sodium sulphate, magnesium sulphate, potassium sulphate, sodium, phosphate, Rochelle salt, ammonium chloride, nitrohydrochloric acid, corrosive sublimate, and calomel.In the third and concluding series, now to be detailed, precisely the same method of experiment has been had recourse to, it having been abun- dantly proved by us, that our method is admirably fitted to yield results of a precise, and therefore reliable, character in this important inquiry.The method of experiment, although fully detailed in the introduction
NARRATION
Authors: Lionel H. Mercier
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
YUGOSLAVIA
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pediatrics
Authors: J. L. Pérez Navero, A. Alvarez Kindelán, I. Ibarra de la Rosa, E. Ulloa Santamaría, M. J. Velasco Jabalquinto, F. Barcones Mingueza, M. Concha Ruiz, F. Pérez-Alvarez, F. Molina, A. Foguet, J. Titus, J. Papadatos, D. Gionis, P. Kalabalikis, D. Kafetzis, R. Rosi, A. Stanca, G. Spargi, E. Zei, J. Sizun, A. Karangwa, O. Masure, J. D. Giroux, A. M. Sinitzis, D. Alix, P. Jouvet, P. Hubert, D. Rabier, J. M. Saudubray, S. Finfer, P. Cox, F. Fleming, G. Barker, D. Bohn, R. J. B. J. Gemke, A. J. van Vught, G. J. Bonsel, F. F. H. Rutten, A. Fantoni, D. Ripamonti, A. Favero, N. Franceschelli, Y. Leykin, C. Bonvicini, R. Reig, M. Delgado, G. Pérez, C. Folgado, F. Criado, J. Caturla, F. Aburto, J. Acosta, I. Morera, A. Infante, A. Barbosa, A. Castellanos, J. L. Teja, F. Santos, T. Obeso, J. P. Santidrian, E. Artiñano, A. Hostalot, L. Jovanl, A. Palomeque, X. Pastor, M. Ribas, R. Jiménez, A. Morelló, C. de la Rosa, N. Orteu, E. Quiñones, A. Moreno, J. Guerola, C. Mortera, J. Mulet, A. Rodríguez-Núñez, L. Redondo, J. M. Martinón, F. Leclerc, Y. Riou, A. Martinot, L. Storme, V. Hue, V. Flurin, J. Primožič, Ž. Zupančič, R. C. Raphaelly, J. Gadzinowski, M. Szymankiewicz, H. L. Halliday, F. Murillo-Cabezas, J. M. Dominguez-Roldan, A. Muñoz-Sanchez, J. L. Santamaria-Mifsut, J. M. Barrera-Chacon, A. Maestre
Journal: Intensive Care Medicine (1992)