tbuckley/cabot-search huggingface dataset:
SYSTEMATIC STUDY OF EDUCATIONAL PROBLEMS.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
451PD Osimertinib at 80 mg for refractory leptomeningeal metastases in T790M-positive EGFR-mutant non-small cell lung cancer
Authors: A. Hata, S. Nanjo, C. Okuda, R. Kaji, K. Masago, S. Fujita, K. Irie, H. Okada, H. Okada, H. Okada, S. Fukushima, N. Katakami
Journal: Annals of Oncology (2016)
Intravenous Therapy
Authors: B. Rattan
Journal: BMJ (1927)

<h3>Introduction</h3> Pipeline embolization devices (PEDs) are designed for delivery through a 0.027” microcatheter such as the Marksman (Medtronic). Challenges with second generation FlexPEDs include limited support from the Marksman for consistent resheathing and providing enough push for delivery. The VIA27 (Sequential) is an alternative 0.027” microcatheter originally designed for intrasaccular flow diverter delivery. Here we describe our experience with the VIA27 in the delivery of PEDs. <h3>Methods</h3> We retrospectively identified patients who underwent PED treatment with the VIA27 microcatheter at our institution. Patient demographics, equipment utilized, intraprocedural catheter positions and periprocedural complications were documented. <h3>Results</h3> 36 patients underwent 40 embolizations of 44 aneurysms with 48 PEDs (Table 1) using the VIA27. The average age was 59.9 ± 11.0 years; 7 (17.5%) were male. Most aneurysms 41 (93.2%) were located anteriorly. The average aneurysm size was 7.2 mm with 38 (86.4%) small, 3 (6.82%) large, and 3 (6.82%) giant. The VIA27 was successfully used to deploy all 48 PEDs (Figure 1). 6 attempts were made to resheath the PED during placement; all were successful. The distal tip of the catheter was located in the ACA 4 (10%), MCA 32 (80%), supraclinoidal ICA 1 (2.5%), basilar 2 (5%), and distal vertebral 1 (2.5). In 3 (7.5%) cases where the VIA27 catheter was unable to track, alternate catheters were used to advance and then exchanged back to the VIA27. In 3 (7.5%) instances, the Marksman was unable to provide adequate push for PED deployment; the VIA27 was exchanged for placement of the PED. No patients experienced iatrogenic vessel injury or other microcatheter associated complications. <h3>Conclusions</h3> The VIA27 is capable of safe FlexPED delivery in the treatment of intracranial aneurysms. We have shown its utility in enhancing both resheathing and push for optimal FlexPED placement. The 0.027” VIA may be a useful and safe adjunct to the more traditional Marksman in FlexPED treatments of cerebral aneurysms. <h3>Disclosures</h3> <b>L. Lin:</b> None. <b>G. Colby:</b> None. <b>R. Xu:</b> None. <b>M. Bender:</b> None. <b>B. Jiang:</b> None. <b>D. Lubelski:</b> None. <b>A. Coon:</b> None.
Leukemia in workers exposed to ethylene oxide
Authors: C. Hogstedt
Journal: JAMA (1979)

Ethylene oxide, a gaseous sterilant extensively used within health care facilities, is known to be a mutagen in bacteria and in human lymphocytes. The Environmental Protection Agency as well as the National Institute of Occupational Safety and Health have recently stipulated certain conditions for the use of ethylene oxide despite the lack of case reports or epidemiologic studies concerning carcinogenicity. We report three cases of leukemia that occurred between 1972 and 1977 in a relatively small group of Swedish workers exposed to ethylene oxide. According to national statistics, 0.2 cases of leukemia would have been expected. The time-weighted average ethylene oxide concentration was 20±10 ppm. (<i>JAMA</i>241:1132-1133, 1979)
Mortality in infants discharged from neonatal intensive care units in Georgia
Authors: D M Allen, J W Buehler, B N Samuels, A W Brann
Journal: JAMA (1989)

Although neonatal intensive care units (NICUs) have contributed to advances in neonatal survival, little is known about the epidemiology of deaths that occur after NICU discharge. To determine mortality rates following NICU discharge, we used linked birth, death, and NICU records for infants born to Georgia residents from 1980 through 1982 and who were admitted to NICUs participating in the state's perinatal care network. Infants who died after discharge (n = 120) had a median duration of NICU hospitalization of 20 days (range, 1 to 148 days) and a median birth weight of 1983 g (range, 793 to 5159 g). The postdischarge mortality rate was 22.7 per 1000 NICU discharges. This rate is more than five times the overall postneonatal mortality rate for Georgia from 1980 to 1982. The most common causes of death were congenital heart disease (23%), sudden infant death syndrome (21%), and infection (13%). Demographic characteristics commonly associated with infant mortality were not strongly associated with the mortality following NICU discharge. (<i>JAMA</i>. 1989;261:1763-1766)
Breast Cancer Clinical Practice Guidelines in Oncology
Journal: Journal of the National Comprehensive Cancer Network (2003)

The American Cancer Society estimates that approximately 205,000 new cases of breast cancer were diagnosed in the United States in the year 2002, and approximately 40,000 patients will die of this disease. The NCCN guidelines discuss the complex and varied therapeutic options for patients with noninvasive or invasive breast cancer. For the most recent version of the guidelines, please visit NCCN.org
AN OPPORTUNITY FOR MEDICAL STUDENTS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health and health services in Central America
Authors: R. M. Garfield
Journal: JAMA (1985)

Despite rapid economic growth since World War II, health conditions improved only slowly in most of Central America. This is a result of poor medical, social, and economic infrastructure, income maldistribution, and the poor utilization of health investments. The economic crisis of the 1980s and civil strife have further endangered health in the region. Life expectancy has fallen among men in El Salvador and civil strife has become the most common cause of death in Guatemala, Nicaragua, and El Salvador. Large-scale US assistance has done little to improve conditions, and refugees continue to pour into North America. It is estimated that there are more than a million refugees within Central America, while a million have fled to the United States. Costa Rica and Nicaragua are partial exceptions to this dismal health picture. An effective approach to the many health problems in Central America will require joint planning and cooperation among all countries in the region. (<i>JAMA</i>1985;254:936-943)
Study Sets of Histologic Slides of Rodent Tumors
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Study Sets of Histologic Slides of Rodent Tumors Get access JNCI: Journal of the National Cancer Institute, Volume 67, Issue 4, October 1981, Page 957, https://doi.org/10.1093/jnci/67.4.957-c Published: 01 October 1981
MBCL-24. CAN YOUNG CHILDREN WITH RELAPSED MEDULLOBLASTOMA BE SALVAGED AFTER INITIAL IRRADIATION-SPARING APPROACHES?
Authors: Craig Erker, Valérie Larouche, Ashley Margol, Chantel Cacciotti, Sébastien Perreault, Kenneth J Cohen, Mohamed S AbdelBaki, Juliette Hukin, Shahrad Rod Rassekh, David D Eisenstat, Beverly Wilson, Jeffrey Knipstein, Anna L Hoppmann, Eric S Sandler, Kathleen Dorris, Taryn B Fay-McClymont, Ralph Salloum, Virginia L Harrod, Bruce Crooks, Jonathan L Finlay, Eric Bouffet, Lucie Lafay-Cousin
Journal: Neuro-Oncology (2020)

Abstract INTRODUCTION Irradiation-sparing approaches are used in young children with medulloblastoma (MB) given the vulnerability of the developing brain to neurocognitive impairment. Limited data are available following relapse for these patients. We aimed to describe the management and outcomes of young children with MB who relapsed after initial treatment without craniospinal irradiation (CSI). METHODS International retrospective study including patients with MB diagnosed between 1995–2017, ≤ 72 months old, initially treated without CSI, who subsequently relapsed. RESULTS Data are available for 52 patients (32 male). Median age at initial diagnosis was 27 months (range, 6–72) with 24 being metastatic. Initial therapy included conventional chemotherapy alone or high-dose chemotherapy (HDC) in 21 and 31 subjects, respectively. Three received upfront focal irradiation. Molecular subgrouping, available for 24 tumors, included 9 SHH and 15 non-WNT/non-SHH. Median time to relapse was 13 months (range, 3–63). Relapse was local, disseminated or combined in 20, 15, and 16, respectively. Salvage therapy with curative intent was given in 42/52 patients, including CSI in 28 subjects (median dose 36Gy, 18–41.4) or focal irradiation in 5 others. Three received HDC only. At a median follow-up time of 46 months (range, 4–255), 25 (48%) were alive, including 7/9 SHH and 7/15 non-WNT/non-SHH. The 2- and 5-year OS was 67% and 56% (SE, 7%), respectively. Two of 3 patients with SHH who did not receive salvage radiotherapy are survivors. CONCLUSION A substantial proportion of young children who relapse following irradiation-sparing strategies can be salvaged. Neurocognitive and ototoxicity outcomes are being evaluated.
INTERRELATIONS OF HORMONES AND VITAMINS
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evils of infusions
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Apothecary Elected Deputy
Journal: BMJ (1841)

POISONING FROM1 ARSENIU.'2.57 unider thle sanction of the latw of at civilized anid professedly Christiin country, aflords an example of callousiiess anid defect of social qtualities in those wlio hiave giveni aiutlhority to such a systcnii, as ImiUst ulti- inaLtely tend to wveaken their powers as legislators for at social people, anid to lesscil that respect fbr the laws generatlly, whiclh is ilecessary to the well-bein^, of any colnmullity or state.
Neuroendocrinology
Authors: Alvin Brodish
Journal: JAMA (1964)

The authors attempt to demonstrate the close relationship between the two major integrating systems of the body, and to show how much neurology and endocrinology have in common. By selected examples, the principles of neuroendocrinology are illustrated in all living forms, both invertebrate and vertebrate, thus providing a comparative point of view. The authors successfully impress upon the reader the similarity of the neuroendocrine mechanisms which are available in many animals for the appropriate adjustments to both internal and external changes. This book is based upon lectures given at Columbia University in 1960. Rather than attempting complete coverage of the field of neuroendocrinology, the authors stress fundamental principles of neuroendocrine integration. An excellent and up-to-date bibliography makes the volume a worthwhile reference source of neuroendocrine literature. The first part of the book considers the principle of neuroendocrine integration and includes a discussion of the afferent pathways employed, the development of
Immunologic Aspects of Diseases of the Eye
Authors: Charles E. Reed
Journal: JAMA (1982)

THE EYE may be the target of allergic inflammation in a variety of systemic immunologic conditions. Ocular signs and symptoms can often be the most striking and disabling aspects of such diseases. The eye is also affected by several local conditions in which immunologic mechanisms are thought to play a significant role. Major structures of the eye are illustrated in Fig 12-1. Immunologically mediated diseases of the skin and mucous membranes, the cornea, and the uveal tract and retina are discussed in the following sections. <h3>DISEASES OF THE SKIN AND MUCOUS MEMBRANES OF THE EYE</h3><h3>Contact Sensitivity</h3> Contact sensitivity is a common condition seen in the practice of ophthalmology. Several commonly used topical ophthalmic preparations are offenders. The patient may experience itching, tearing, and sensitivity to light. The eyelids are at first erythematous and indurated but, with long-term exposure to the agent, scaling and lichenification occur (Fig 12-2). In general,
Psychoneuroimmunology
Authors: Michael Irwin
Journal: JAMA (1992)

The field of psychoneuroimmunology was first pioneered over 25 years ago in an effort to understand the influence of emotional states on human health and resistance to disease. Current explication of this concept has been refined as interdisciplinary research has begun to define the pathways and mechanisms of communication between the nervous system, the endocrine system, and the immune system. Publication of the second edition of<i>Psychoneuroimmunology</i>substantively updates the 1981 edition and summarizes emergent new data that document reciprocal, bidirectional relations between the brain and the immune system. In this volume, edited by a behavioral psychologist (Ader), a neuroscientist (Felten), and an immunologist (Cohen), a remarkable series of contributions from over 70 scientists has been collected to provide a comprehensive yet focused analysis of behavioral-neural-endocrineimmune interactions. Areas of general research have been organized into four sections: the first and second sections document the neural connections and endocrine influences on
Committee on Cosmetics
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eyeball Bruits
Authors: Jonas H. Cohen, Stanley Miller
Journal: New England Journal of Medicine (1956)

SELDOM do physicians, including ophthalmologists, employ auscultation over the face and head areas as an adjunct to clinical observation. More routine use of the stethoscope over the eyeball itself will demonstrate the presence of bruits that are overlooked because hitherto they have been associated with few specific concomitant findings. More frequent auscultation may reveal the presence of a bruit as a sign in some relatively common pathologic entities. Within a period of two years, 7 cases of eyeball bruit were discovered by us on the medical service of a 370-bed general hospital. A review of the literature and communication with . . .
NEW INVENTIONS.
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magazines without tobacco advertising
Journal: JAMA (1991)

INQUIRIES from many physicians reveal that they've been watching for an update ofThe Journal'slist of publications that carry no cigarette or other tobacco advertisements. Here it is. Since its first list appeared (<i>JAMA</i>. 1989;262:1290-1291,1295), the length has more than doubled. Credit for the idea of having only "smoke-free magazines" in physicians' reception rooms goes to DOC (Doctors Ought to Care), a group of physicians devoted to educating people about the causes of preventable illness. Publication of such a list in<i>JAMA</i>follows a resolution adopted by the American Medical Association's House of Delegates 2 years ago. Of the making of magazines there is apparently no end. This list includes all that could be verified, but there are probably many more. The<i>JAMA</i>Medical News &amp; Perspectives Department will be pleased to hear about them—for the next list. Accent on Living PO Box 700 Bloomington, IL 61701 Adirondack Life
代谢表型标志物对人类皮肤黑色素瘤预后的影响
Authors: L. Nájera, M. Alonso‐Juarranz, M. Garrido, C. Ballestín, L. Moya, M. Martínez‐Díaz, R. Carrillo, A. Juarranz, F. Rojo, J.M. Cuezva, J.L. Rodríguez‐Peralto
Journal: British Journal of Dermatology (2019)

黑色素瘤是最具侵袭性的皮肤肿瘤,是皮肤癌致死的主要原因。其发病率的增长速度比排名前十的任何一种癌症都要快。由于缺乏有效的疗法,很少有转移患者(这意味着癌症已经扩散到身体的其他部位)在确诊后存活超过一年。并不是所有的黑色素瘤都是一样的,它们在侵袭性(发展和潜在传播的速度)和外观上各不相同。本研究的作者来自西班牙,他们研究了具有不同侵袭性特征的培养黑色素瘤细胞(在实验室的样本中生长)和患有不同类型黑色素瘤病变的患者。他们的目的是在黑色素瘤中发现可以预测疾病发展的代谢标志物。细胞代谢是生物体为了维持生命而发生的一系列化学反应。现在已经知道,癌细胞的新陈代谢不同于正常细胞,因为它们生长和分裂迅速,需要高能量供应。在这种情况下,作者发现与能量产生相关的蛋白质(酶)发生了变化。这些蛋白质包括:ATP合酶(β‐F1‐ATPase)、热休克蛋白60 (HSP60)、糖酵解甘油醛‐3‐磷酸脱氢酶 (GAPDH) 以及丙酮酸激酶M2 (PKM2)。这些蛋白质能提供癌症的生物能量学特征(BEC 指数=β‐F1‐ATPase/HSP60/GAPDH 比率)。BEC 指数的降低与培养的黑色素瘤细胞和肿瘤的侵袭性以及黑色素瘤患者整体存活率的下降有关。作者得出结论,认为代谢酶水平和 BEC 状态是黑色素瘤分期(进展程度,例如,它是否已扩散以及扩散了多少)和黑色素瘤患者整体存活率的指标。