tbuckley/cabot-search huggingface dataset:
Prostate-specific mRNA detection in whole blood as an analytically validated prognostic biomarker for patients with castration-resistant prostate cancer (CRPC).
Authors: Daniel Costin Danila, Aseem Anand, Glenn Heller, Mingliang Wan, Amrita Herkal, Chintan Patel, Raya Khanin, Nikolaus Schultz, Hans Lilja, Martin Fleisher, Howard I. Scher
Journal: Journal of Clinical Oncology (2013)

45 Background: To estimate the association between molecular biomarkers and outcomes, robust assays are needed before qualification in prospective trials. Although tumor specific transcripts detected in blood by PCR have been associated with outcome, an analytically validated PCR platform enabling detection of CTC-associated transcripts in clinical settings remains to be identified. Here we explore detecting a panel of prostate specific transcripts in conjunction with conventional markers in CRPC. Methods: Blood was collected from 97 patients with progressive CRPC in PAXgene tubes (2.5 ml) for total RNA extraction. Five genes expressed in prostate but not in nucleated blood cells were analyzed by primer-specific RT-PCR. Fluidigm Dynamic Array platform was analytically validated for KLK3, KLK2, HOXB13, GHRL2 and FOXA1 assays. Each PCR-reaction was run in 6 replicates, detection thresholds for each gene were chosen by ROC analysis of an independent set of 56 CRPC patients versus 51 healthy volunteers, and results were reported as transcripts present or absent. CellSearch reported CTC number/7.5 ml of blood drawn into CellSave tube. Results: Prostate specific transcripts for KLK3, KLK2, HOXB13, GHRL2 and FOXA1were detected in 50 (52%), 39 (40%), 53 (55%), 28 (29%) and 47 (48%) of patients, respectively.Two or more genes were detected in 53/97 patients (55%, 95% CI 45-65%) of patients with progressive CRPC studied with a median survival time of 17 months (95% CI: 13.8, 23.5). 40/45 CRPC-patients with ≥5 CTC and 13/52 CRPC patients with &lt;5 CTC had transcripts present in blood. CTC and the gene panel had a substantial level of agreement, kappa of 0.631 (95% CI: 0.479, 0.783). Transcript detection predicted overall survival in proportional hazards models that included LDH dichotomized at 250. The predictive accuracy (CPE) of PCR detection + LDH was 0.759 (SE 0.035), comparable to CTC-enumeration + LDH (0.771, SE 0.033). Conclusions: Detecting prostate specific mRNA in whole blood using validated RT-PCR assays, applicable to larger CRPC cohorts, provides prognostic value. The clinical utility in monitoring treatment will be prospectively explored.
Phenomenon of Purified Protein Derivative and Histamine Neutralization
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Physiology
Authors: J. G. Greene
Journal: JAMA (1982)

This book was designed to provide first-year medical students and paramedical personnel with a complete background in pulmonary physiology sufficient to understand clinical medicine. Each chapter begins with a series of objectives. Suggested readings for each chapter are appended at the end of the book, along with a few selected study questions. The manuscript is interestingly organized along the lines of the National Heart, Lung, and Blood Institute care curriculum with regard to a major topic. The objectives, however, are more detailed and expanded in number. The format is designed for easy reading and study. This volume includes most subject material that a first-year student might need, but the explanations are often very brief. As one checks through the book, universally taught topics are mentioned: anatomic and physiological dead space are covered in five pages, while closing volume is reviewed in 1 1/2 pages of script. The response to exercise
Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension?
Authors: J. H. Markovitz
Journal: JAMA (1993)

<h3>Objective.</h3> —To test the hypothesis that heightened anxiety, heightened anger intensity, and suppressed expression of anger increase the risk of hypertension, using the Framingham Heart Study. <h3>Design.</h3> —A cohort of men and women without evidence of hypertension at baseline were followed up for 18 to 20 years. Baseline measures of anxiety (tension), anger symptoms, and expression of anger (anger-in and anger-out) were taken, along with biological and behavioral predictors of hypertension (initial systolic blood pressure, heart rate, relative weight, age, hematocrit, alcohol intake, smoking, education, and glucose intolerance). <h3>Participants.</h3> —A total of 1123 initially normotensive persons (497 men, 626 women) were included. Analyses were stratified by age (45 to 59 or ≥60 years) and gender. <h3>Main Outcome Measures.</h3> —Hypertension was defined as either taking medication for hypertension or blood pressures higher than 160/95 mm Hg at a biennial examination. <h3>Results.</h3> —In univariate analyses, middle-aged men who went on to develop hypertension had greater baseline anxiety levels than men who remained normotensive (<i>P</i>=.04). Older hypertensive men had fewer anger symptoms at baseline (<i>P</i>=.04) and were less likely to hold their anger in (<i>P</i>=.01) than normotensives. In multivariate Cox regression analysis including biological predictors, anxiety remained an independent predictor of hypertension in middle-aged men (<i>P</i>=.02). Among older men, anger symptoms and anger-in did not remain significant predictors in the multivariate analysis. Further analysis showed that only middle-aged men with very high levels of anxiety were at increased risk (relative risk, 2.19; 95% confidence interval, 1.22 to 3.94). No psychological variable predicted hypertension in middle-aged or older women in either univariate or multivariate analyses. <h3>Conclusions.</h3> —The results indicate that among middle-aged men, but not women, anxiety levels are predictive of later incidence of hypertension. (<i>JAMA</i>. 1993;270:2439-2443)
Longevity
Authors: Amran Scheinfeld
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The EDITORIAL regarding longevity inThe Journal(224:1289, 1973) gives credence to the highly dubious reports of phenomenal numbers and age (130 years or older) of centenarians in Ecuador and the Soviet Union. The fact is that the reported modern Methuselahs are invariably persons in remote regions and among backward groups for whom no reliable birth records are available, and whose reputed ages have long been discounted by demographers. Thus, in the United States (where there also have been reports of individuals aged 130 years or older—usually ex-slaves), government experts have greatly discounted the estimates of numbers of centenarians and claims of phenomenal ages. For example, in a vital statistics report for 1960, half of the 80 persons listed as having died at ages of 110 or older— and all seven who had allegedly been 120 or older (two "124," one "128")— were nonwhites, although these constituted
February 2013
Authors: T. Bleiker
Journal: British Journal of Dermatology (2013)

Benzekri L, Gauthier Y, Hamada S, Hassam B. Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo. Br J Dermatol 2013; 168: 265–271. doi: 10.1111/bjd.12034 Visser MJ, Landeck L, Campbell LE et al. Impact of atopic dermatitis and loss-of – function −mutations in the filaggrin gene on the development of occupational irritant −contact dermatitis. Br J Dermatol 2013; 168: 326–332. doi: 10.1111/bjd.12083 Papp KA, Langley RG, Sigurgeirsson B et al. Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study. Br J Dermatol 2013; 168: 412–421. doi: 10.1111/bjd.12110 Blok et al. report a systematic review of systemic retinoids and immunosuppressants in adults with hidradenitis suppurativa (HS). A total of 87 papers were included, comprising 518 patients with HS who were treated with systemic retinoids, biologic agents or other immunosuppressive agents, including colchicine, ciclosporin, dapsone or methotrexate. Overall, the quality of evidence was low and differed between the agents, making direct comparisons difficult. Infliximab, adalimumab and acitretin were the most effective systemic agents, although the quality of evidence for acitretin was lower than that for infliximab and adalimumab. Randomized controlled trials are needed to identify the most effective treatment targets and the most effective therapy for HS. Blok JL, van Hattem S, Jonkman MF, Horváth B. Systemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review. Br J Dermatol 2013; 168: 243–252. doi: 10.1111/bjd.12104
Relapse of gram-negative bacillary meningitis after cefotaxime therapy
Authors: R. W. Bradsher
Journal: JAMA (1982)

CONSIDERABLE enthusiasm has developed regarding the treatment of gram-negative bacillary meningitis with newly developed broad-spectrum, third-generation cephalosporin antibiotics.<sup>1,2</sup>Compared with other agents such as aminoglycosides or previously available cephalosporins, these antibiotics have remarkable activity against the organisms that cause this life-threatening infection.<sup>3</sup>The degree of penetration across the blood-brain barrier is so much greater for third-generation cephalosporins than the previously utilized antibiotics for gram-negative bacillary meningitis that many investigators now suggest that either cefotaxime sodium or moxalactam disodium is the drug of choice for this infection.<sup>1</sup>Since the proved therapy of intraventricular aminoglycoside administration may be associated with serious hazards,<sup>4</sup>the relative safety of cephalosporins is attractive. The relapse rate, however, has not been determined for this therapy with new cephalosporins. We recently gave one of these agents to a patient with gram-negative bacillary meningitis and observed an adequate initial response followed by relapse of infection.
Gut hormones and receptors
Authors: A Nowak, M Blaszczyrsska, E Nowakowska-Dulawa, G Varga, H Wong, J Walsh, D Campbell, T Solomon
Journal: Gut (1994)

3rd UEGWOslo 1994 prestenotic dilation in 16 cases, 25 ductal concrements, 11 a disruption of WD, 11 pseudocysts corresponding to the duct, and 7 parenchymal concre- ments obstructing the outflow.The initial diagnosis of CP had to be corrected in five patients: twice there was a tumor stenosis and acute pancreatitis.Sclerosing pancreatitis was found once.In two patients CP was diagnosed, but there was no evidence of obstruction of WD and intervention was done without.Endoscopic therapy was indicated in 35/42 patients (83%).The in- terventions included 32 EST, 10 stentings, 4 stone extractions by ballon and 24 times short-time nasopancreatic drainage. 18sessions of extracorporal shock wave lithotripsy (ESWL) were necessary in 12 patients with pancreatic duct stones or parenchymal calculi.Endoscopic therapy was technically suc- cessful in 30 of 35 cases (85%).Technical failure was due to one 90 degree angle in the proximal WD, 3 disruptions and one stenosis that could not be passed with the guidewire.These settings were further complicated by ex- tensive parenchymal calculi in three cases and duct stones in one patient.No postinterventional pancreatitis was observed.The only complication resulted in one papillary bleeding, that was stopped by sclerosing therapy.In conclu- sion, endoscopic therapy of CP with obstruction succeeded in 75 %.It led to immediate relief of pain in all successfully treated patients.Nevertheless, 30 % of the patients had to have reintervention within one year for stent occlu- sion or recurrent pain.2/35 patients underwent pancreaticojejunostomy for definite relief of pancreatic obstruction.4 Endoscopic Sphincterotomy (ES) Applied for Acute Biliary Pancreatitis (ABP) Prevents Further Attack of this Disease.A Prospective Follow-Up Study
DISEASES OF METALS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase II study of onvansertib in combination with abiraterone and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC).
Authors: David Johnson Einstein, Atish Dipankar Choudhury, Philip James Saylor, Jesse Christopher Patterson, Peter Croucher, Maya Ridinger, Mark G. Erlander, Michael B. Yaffe, Glenn Bubley
Journal: Journal of Clinical Oncology (2021)

TPS186 Background: Metastatic CRPC remains a leading cause of cancer-related deaths worldwide. Although abiraterone + prednisone (abi) in either the castration-sensitive or castration-resistant setting increases survival, resistance is universal and generally occurs within 9-16 months of initiating treatment. Polo-like kinase 1 (PLK1) is a serine/threonine protein kinase that regulates mitotic functions and progression, and it is highly upregulated in prostate cancer following castration. Onvansertib is an oral and highly-selective PLK1 inhibitor that demonstrated safety and tolerability in a Phase 1 trial. Preclinical studies showed that PLK1 inhibition enhanced abi efficacy in cell line models and in patient-derived tumor xenografts via an AR-independent mechanism. Transcriptomic analyses revealed that abi induced mitosis-related gene sets in cells synergistic for abi + onvansertib, and identified an abi-onvansertib synergy gene signature. Methods: The goal of this phase 2 study (NCT03414034) is to observe the effects of onvansertib in combination with abi on disease control, as assessed by prostate-specific antigen (PSA) decline or stabilization after 12 weeks of study treatment, in subjects with mCRPC and early resistance to abi. Patients are enrolled at time of PSA progression while on standard abi. Patients with prior treatment with enzalutamide or apalutamide are excluded. Three onvansertib dosing schedules are tested in noncomparative arms: arm A (24 mg/m 2 on days 1-5 of a 21-day cycle), arm B (18 mg/m 2 on days 1-5 of a 14-day cycle), and arm C (12 mg/m 2 on days 1-14 of a 21-day cycle). The 3 arms have completed their safety-lead phases and expansion phases are ongoing. With 32 patients in each arm, there will be 90% power to detect a change in disease-control rate from 10% (null) to 30% (alternative). Based on a Simon’s two-stage optimal design, the study will terminate early if &lt; 2 of the first 13 patients in each arm achieve disease control. Exploratory analyses include evaluation of the presence of the androgen receptor variant 7 (AR-V7) in circulating tumor cells and targeted genomic profiling of circulating tumor DNA to assess associations between genomic alterations and response to treatment. Additionally, transcriptomic analysis of archived tumor tissue will be performed to determine whether enrichment for gene expression signatures, such as the abi-onv synergy signature identified in preclinical models, could be used to predict clinical response. Clinical trial information: NCT03414034.
Mumps Outbreak at a Summer Camp—New York, 2005
Journal: JAMA (2006)

On July 26, 2005, the Sullivan County Health Department (SCHD) and the New York State Department of Health (NYSDOH) were notified of a cluster of cases of parotitis among campers and staff members at a summer camp. An investigation conducted by NYSDOH identified 31 cases of mumps, likely introduced by a camp counselor who had traveled from the United Kingdom (UK) and had not been vaccinated for mumps. This report summarizes the results of the subsequent investigation by NYSDOH, which determined that, even in a population with 96% vaccination coverage, as was the case with participants in the summer camp, a mumps outbreak can result from exposure to virus imported from a country with an ongoing mumps epidemic.
Derivation and validation of prognostic nomogram for HBV-related acute-on-chronic liver failure
Authors: Jun-Feng Chen, Weizhen Weng, Miao Huang, Xiaohua Peng, Hui-Juan Cao, Shaoquan Zhang, Jing Xiong, Jing Zhang, Dengna Lin, Zhiliang Gao, Bingliang Lin
Journal: Journal of Hepatology (2020)
Therapeutic Uses of Digoxin Antibody
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Race, socioeconomic status, and domestic homicide
Authors: B. S. Centerwall
Journal: JAMA (1995)

<h3>Objective.</h3> —A study of 222 intraracial domestic homicides in Atlanta, Ga, found that when black and white populations were unstratified, the relative risk of homicide in black populations was 5.8 (95% confidence interval [CI], 4.3 to 8.0); when black and white populations were stratified by rates of household crowding, the relative risk of homicide in black populations was no longer significantly elevated (relative risk [RR], 1.2; 95% CI, 0.7 to 2.0). The current study sought to replicate, or not replicate, these findings in New Orleans, La. <h3>Methods.</h3> —Retrospective study of 349 intraracial domestic homicides perpetrated against residents of Orleans Parish in 1979, 1982, 1985, and 1986. <h3>Main Outcome Measure.</h3> —Relative risk of homicide in the black and white populations of New Orleans when they are stratified by rates of household crowding. <h3>Results.</h3> —When black and white populations of New Orleans were unstratified, the relative risk of intraracial domestic homicide in black populations was 6.3 (95% CI, 4.3 to 9.5). When black and white populations were stratified by rates of household crowding, the relative risk of homicide in black populations was no longer significantly elevated (RR, 1.2; 95% CI, 0.4 to 2.9). <h3>Conclusion.</h3> —The findings of the Atlanta homicide study are replicated in the current study of homicide in New Orleans. In both cities, sixfold differences in black and white rates of intraracial domestic homicide are entirely accounted for by differences in socioeconomic status between the respective black and white populations. There are no significant residual differences requiring cultural explanations. (<i>JAMA</i>. 1995;273:1755-1758)
Dr. Erna Lesky's Name Misspelled
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Weight Change With Orally Administered "Antidiabetic" Drugs
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal