tbuckley/cabot-search huggingface dataset:
Table Sidehead Omitted
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ovarian carcinoma presenting as a vaginal lesion
Authors: S. Lifshitz
Journal: JAMA (1978)

THE presenting symptoms of ovarian carcinoma are usually nonspecific; vague abdominal discomfort, gastrointestinal disturbances, and increasing abdominal girth occur in 80% of patients. Rarely, ovarian carcinoma may present as an umbilical hernia, with vaginal bleeding, or with inguinal lymphadenopathy. Ovarian carcinoma presenting as a vaginal lesion is unusual and is not reported in current gynecologic texts or recent English medical literature. Vaginal involvement in advanced ovarian carcinoma usually occurs late in the course of disease. Bergman<sup>1</sup>reported vaginal involvement in 12% in an autopsy series of 86 patients with advanced ovarian carcinoma. <h3>Report of Cases</h3> Ovarian carcinoma presenting primarily as a vaginal tumor was seen in five patients over a period of seven years on the oncology services at the University of Iowa Hospitals and at the Strong Memorial Hospital, University of Rochester College of Medicine and Dentistry. The clinical details of these patients are presented in the Table.
Orthotopic liver transplantation in two adults with Niemann-Pick and Gaucher's diseases: Implications for the treatment of inherited metabolic disease
Authors: E Smanik
Journal: Hepatology (1993)

Two adults were seen with cirrhosis caused by different lipid storage diseases. A 42-yr-old woman with Niemann-Pick disease type B had marked hepatomegaly, ascites and recent variceal bleeding. Her evaluation showed chronic bilateral pulmonary infiltrates, multiple stigmata of chronic liver disease including the recent cessation of menses, diuretic-resistant sterile ascites, hepatic encephalopathy and variceal bleeding. Five percent of normal sphingomyelinase activity was measured in peripheral leukocytes. A 42-yr-old man with Gaucher's disease and a history of bilateral hip replacements presented with hepatomegaly, jaundice, refractory ascites and renal insufficiency. His evaluation showed 20% to 23% of normal glucocerebrosidase activity in peripheral leukocytes. Both patients underwent orthotopic liver transplantation with resolution of all aspects of decompensated liver function. Assessment of the underlying metabolic defect before and 6 to 14 mo after transplantation showed that after transplantation the patient with Niemann-Pick disease had above normal hepatic sphingomyelinase activity, a less-marked increase in peripheral leukocyte enzyme activity and lower than normal hepatic sphingomyelin and cholesterol content. In contrast, the patient with Gaucher's disease had only a 61% increase in hepatic glucocerebrosidase activity but had an elevated hepatic glucocerebroside content that was only 15% of the pretransplant level and decreased peripheral leukocyte enzyme levels. These findings suggest that variable relationships may exist between posttransplant hepatic and peripheral leukocyte enzyme activities in the different lipidoses, which may have implications for recurrence of glycolipid-induced liver damage. (HEPATOLOGY 1993;17:42–49.)
HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis
Authors: Fujun Yu, Bicheng Chen, Peihong Dong, Jianjian Zheng
Journal: Molecular Therapy (2020)

(Mol Ther. 25, 205–217; January 4, 2017) The authors have discovered that the original article has errors in Figures 2A and 2B that were introduced when a graduate student used the wrong shared image folder when putting together the figures. In the original Figure 2A, which shows the Masson staining, the image for the CCl4+Ad-shCtrl group was mistakenly selected from the CCl4 group instead of the right images corresponding to the mice used for this manuscript. The corrected Figure 2A appears below. In the original Figure 2B, which shows the α-SMA immunohistochemistry, the image for the CCl4+Ad-shCtrl group was mistakenly selected from the CCl4 group instead of the right images corresponding to the mice used for this manuscript. The corrected Figure 2B now appears below. These corrections do not change the conclusions of the paper and the authors apologize for the error and any confusion they may have caused. HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver FibrosisYu et al.Molecular TherapyDecember 8, 2016In BriefJianjian Zheng and colleagues found that HOTAIR was upregulated in activated HSCs during liver fibrosis and loss of HOTAIR suppressed HSC activation. They demonstrated that HOTAIR downregulates miR-29b and attenuates its control on DNMT3b, leading to restoration of DNMT3b and enhancement of PTEN methylation, which contributes to liver fibrosis. Full-Text PDF Open Archive
Environment May Exert Some Influence On Incidence of Antinuclear Factor
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Tuberculosis in blacks--United States
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TRANSFUSION REACTIONS AND CITRATION WITHIN THE NEEDLE
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLIMATE AND BUBONIC PLAGUE
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Steroids in Treatment of the Nephrotoxic Syndrome in Adults
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase III trial of docetaxel versus docetaxel and radium-223 (Ra-223) in patients with metastatic castration-resistant prostate cancer (mCRPC): DORA.
Authors: Michael J. Morris, Ronald De Wit, Nicholas J. Vogelzang, Scott T. Tagawa, Celestia S. Higano, Paul Hamberg
Journal: Journal of Clinical Oncology (2021)

TPS5091 Background: Ra-223, a bone-targeted alpha therapy, prolongs survival in patients (pts) with symptomatic mCRPC to bone. Docetaxel targets microtubule trafficking improving survival in the mCRPC and metastatic hormone-sensitive settings. We hypothesized that simultaneously targeting the tumor and bone compartment yields superior outcomes than targeting either alone. We previously determined the dose and schedule of co-administering Ra-223 + docetaxel in a randomized phase I/IIa trial. The combination appeared to have improved declines in prostate specific antigen (PSA) and bone markers, delayed PSA progression, and was better tolerated (with adjusted dose/schedule) relative to standard docetaxel alone. We are now conducting a phase III study to determine the clinical benefit of the regimen. Methods: Randomization (1:1) of 738 men with mCRPC to docetaxel or docetaxel + Ra-223 is planned with a projected hazard ratio for treatment effect (15 vs 20 months median survival) of 0.75. Pts with ≥2 bone lesions and progression by Prostate Cancer Working Group 3 criteria are eligible. Other key inclusion criteria are an Eastern Cooperative Oncology Group performance status of 0–1 and normal organ function. Key exclusion criteria are: use of anticancer therapy ≤4 weeks (wks) before randomization and use of bone-seeking radiopharmaceuticals or chemotherapy in the castration-resistant setting, and bulky visceral metastases (≥3 lung and/or liver or a lesion ≥2 cm in the previous 8 wks). Subjects receive docetaxel 75 mg/m 2 IV q3w for 10 doses or docetaxel 60 mg/m 2 IV q3w for 10 doses + Ra-223 55 kBq/kg IV q6w for 6 doses. The primary endpoint is overall survival. Secondary and exploratory endpoints include: radiographic progression-free survival, symptomatic skeletal event-free survival, safety, markers of bone metabolism, alterations in circulating tumor cells and DNA, detection of androgen-receptor splice variant 7, changes in automated bone scan index (aBSI), and assessment of patient-reported outcome instruments (FACT-P, Brief Pain Inventory, Brief Fatigue Inventory). The study is open at 32 sites in the US and Netherlands and has 170 subjects enrolled. The study is sponsored by Memorial Sloan Kettering Cancer Center, and managed by the Prostate Cancer Clinical Trials Consortium. Clinical trial information: NCT03574571.
Separating cardiac from pulmonary dyspnea
Authors: T. A. Raffin
Journal: JAMA (1977)

DYSPNEA is an uncomfortable awareness of the act of breathing, leading to a sensation most conveniently described as breathlessness. It may arise as a result of numerous mechanisms.<sup>1,2</sup>However, in both cardiac and pulmonary disease, the most common cause is disordered lung mechanics. The two major forms of disordered lung mechanics that result in pulmonary dyspnea are obstructive lung diseases, causing increased airway resistance, and restrictive lung diseases, causing increased lung stiffness. In patients with cardiac dyspnea, the major cause of dyspnea also is increased lung stiffness, leading to a type of restrictive lung disease. As a result, patients with dyspnea purely related to obstructive lung disease seldom pose a problem in the separation of cardiac and pulmonary dyspnea. Hyperinflated lungs, prolonged expiration, a small heart, and the bedside and laboratory evidence of airways obstruction are easily documented. The situation with respect to the restrictive lung diseases is more
GENE-01. TUMOR MUTATIONAL BURDEN AND DRIVER MUTATIONS: FURTHER INSIGHT INTO THE GENOMIC LANDSCAPE OF PEDIATRIC BRAIN TUMORS
Authors: Roshal Patel, Shakti Ramkissoon, Jeffrey Ross, Lauren Weintraub
Journal: Neuro-Oncology (2019)

Tumor mutational burden (TMB) and driver mutations are potential biomarkers to predict efficacy of immune checkpoint inhibitors (ICPI). Studies demonstrated malignant gliomas with high TMB in children and adults may preferentially benefit from treatment with ICPI. Higher TMB has been found to relate to lower incidence of driver mutations, but this relationship has not been studied in pediatric brain tumors. To characterize this association, comprehensive genomic profiling (CGP) was performed on 723 pediatric (≤21 years) brain tumor samples using DNA extracted from 40 microns of formalin-fixed paraffin-embedded tissue. CGP utilized hybridization-captured, adaptor ligation based libraries sequenced to a mean coverage depth of >500X for up to 315 cancer-related genes. TMB was calculated as mutations per megabase and categorized as low (0–6), intermediate (6–20), or high (20+). Analysis included 79 clinically relevant driver mutations; genomic alterations known to confer a selective growth advantage. Of 723 brain tumors, TMB was low in 91.8%, intermediate in 6.1%, and high in 2.1%. When excluding tumor suppressor genes (TSGs), there was an association between decreased incidence of driver mutations in tumors with high TMB (p<0.001). Additionally, we determined that BRAF alterations were not identified in high TMB tumors, but were enriched in low TMB tumors (p<0.01). When including TSGs, however, 93% of tumors in the high TMB cohort harbored a driver mutation; 63% and 70% in the low and intermediate TMB cohorts, respectively (p<0.05). There is an association between high TMB and incidence of TSG alterations (p<10-10), especially TP53 mutations (p<10–13). Of the 15 tumors with high TMB, 14 were high grade gliomas and had alterations in TP53. Three biallelic mismatch repair mutations identified were MSH2, MSH6, and PMS2; they were associated with a higher TMB (p<0.01). These represent populations in which ICPI may be more or less effective and further studies are needed.
From the Centers for Disease Control and Prevention. Nutritional needs surveys among elderly--Russia and Armenia, 1992
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Notices
Authors: Bonny Mower
Journal: Hepatology (1985)

Sponsored by Scripps Clinic and Research Foundation, La Jolla, California, this course is designed for physicians in the fields of gastroenterology, internal medicine, general and family practice and pediatrics who are interested in the pathogenesis, diagnosis and management of gastroenterological disorders commonly encountered in practice.The conference will provide participants with new information and ideas on inflammatory bowel disease, gallstone formation and dissolution, hepatitis, cyto-protection of the upper GI tract and treatment recommendations for acute and chronic peptic ulcer disease, among other disease entities.Seven hours of Category I credit, AMA, will be granted.
Part-of-the-day hypertriiodothyroninemia caused by desiccated thyroid
Authors: A. Lev-Ran
Journal: JAMA (1983)

<h3>In Reply.—</h3> We agree with Dr Walsh et al that the relationship between sleep-related oxygen desaturation and sickle cell disease warrants further study. Our findings do not presume that the nocturnal desaturation is necessarily a primary abnormality of sickle cell disease but rather that it is related to some degree of secondary chronic pulmonary dysfunction, which commonly occurs in these patients. In either case, however, we maintain that sleep-related desaturation may increase the vulnerability of such patients by initiating further sickling and vaso-occlusion. It is true that the enlarged tonsils in patient 1 might lead one to propose that the desaturation was caused by an insidious obstructive apnea. However, we did restudy patient 1 after tonsillectomy and adenoidectomy using a transcutaneous partial oxygen pressure monitor. We also found that Po<sub>2</sub>levels fell during sleep from a baseline of 67 mm Hg to a level of 30 to 40 mm
Topics in radiology. Case of the month. A colocutaneous fistula in the inguinal area
Authors: L. C. Doubleday
Journal: JAMA (1982)

<h3>History</h3> A 52-year-old woman experienced sudden pain in her right groin while feeding bales of hay to cattle. A tender swelling appeared in her right groin 48 hours later. One week later she saw her family physician because of reddened swelling in the groin. The swelling was assumed to represent an abscess and was incised. Fecal drainage developed from the site of the incision. Three weeks later the patient was admitted to the hospital and a barium enema examination was performed (Fig 1 and 2). <h3>Diagnosis</h3> Richter's hernia of the cecum. The barium enema examination demonstrated a knuckle of cecum (lateral margin) extending beneath the inguinal ligament to the site of the draining sinus. Figure 1 is a lateral roentgenogram demonstrating the intestinal-cutaneous fistula (arrows). Figure 2 is an anteroposterior roentgenogram showing knuckle of cecum herniated into the femoral canal (arrow). <h3>Comment</h3> A laparotomy was performed that established that the
Etiology of Atrioventricular Block
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal