tbuckley/cabot-search huggingface dataset:
Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery
Journal: BMJ (2004)

Questions such as how clinicians can be patient centred in email consultations require innovative approaches to researching consultations that place emphasis on semantics (as written words are the sole conveyors of information).Because of the intricate ways in which email combines human communication and information communication technology, interdisciplinary research is essential.We know that a large part of a verbal message's impact derives from the communication style and the clinician's "image" and appearance rather than the content.Will the user interface and the application's functionality (that is, the program design and layout) take this role in email consultations and become a critical element in the human-computer-human interaction?Examples of questions about interface design include, "Should different interfaces be used for different populations considering factors such as age, preferred language, and (computer) literacy?"As email consulting increases, we need to ensure that those without email access to care are not unduly disadvantaged (see fig 2 and box 2).Mechanisms for ensuring equitable access to care for sections of the population who do not use email are essential. ConclusionsHealthcare systems are evolving throughout the world and are now embracing the concepts of patientclinician partnership and patient self-management.In this context, email consultations provide exciting possibilities to augment and facilitate healthcare delivery.
Memorable Days in Medicine: A Calendar of Biology and Medicine
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SCHOOL LIGHTING.
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heterogeneity of Y2-Myeloma Proteins
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of glycoprotein IIb/IIIa receptor inhibition on in-lab adverse events and subsequent CK-MB elevation during percutaneous coronary intervention in ESPRIT Fouad A. Bachour, James C. Blankenship, Elias A. Iliadis, Gudaye Tasissa, JC. O'Shea, Michael M. Kitt, Todd J. Lorenz, James E. Tcheng. Geisinger Medical Center, Danville, PA, Duke Clinical Research Institute, Durham, NC
Journal: Journal of the American College of Cardiology (2001)
June 20, 1864
Authors: Phil Gunby
Journal: JAMA (1986)

It was on this date—June 20—that he wrote the three-page note to my distant relative (separated from me by 122 years). His stationery was a pad of white paper, horizontally lined at approximately half-inch intervals in the fashion that has guided the schoolchild's beginning penmanship for generations. But his is no schoolboy's scrawl. The handwriting, still clear on the yellowing paper despite having been done in pencil, is neat, precise—usually five words to a line, 21 lines to the page. Ironically, only the signature is unclear. It appears to be "J. B. Baker." He writes from a Union Army encampment somewhere "Before Petersburg, Va," only slightly more than 100 miles south of Washington, DC, on the evening of June 20, 1864, and he tells the woman who is my far-removed relative in the westernmost county of New York state: "Your note inquiring in relation to your husband reached me tonight.
DIPHTHERIA MORTALITY IN THE LARGE CITIES OF THE UNITED STATES IN 1924
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DEFENSE OF OPIUM EATING.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PARKINSON—PHYSICIAN, ORYCTOLOGIST, AND SOCIAL REFORMER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculosis Congresses.
Authors: Arnold C. Klebs
Journal: JAMA (1903)

Chicago, Dec. 12, 1903. <h3>To the Editor:</h3> —Your editorial in the last number ofThe Journalon "Tuberculosis Congresses" is most timely, and it is to be hoped that it will prevent misunderstandings in the future. Those actively working in the local associations for the prevention of tuberculosis have so far not cared to define their position in regard to these so-called "American" congresses; their time has been more usefully employed in perfecting their organization and preventative methods, and no doubt in time this will bring about the formation of a national body for the purpose of standardizing and generalizing their measures. It is indeed unfortunate that any number of men can combine and call themselves "American Congress" and by virtue of that name alone, not only persuade the unsuspecting medical and lay public of its representative character, but even as in the case of the "Bell Congress" receive the
SOME RECENT ASPECTS OF VITAMIN B RESEARCH
Journal: JAMA (1927)

The stimulus for the early studies in the field now designated as that of dietary deficiency disorders was derived in no small measure from experiments on birds. The starting point was the production of experimental polyneuritis—polyneuritis gallinarum—in hens and the demonstration that it could be averted or cured through the use of suitable food alone. The pioneer investigations of the Dutch scientists Eijkman and Grijns, working in Java, paved the way for Funk's studies on pigeons, researches responsible for the introduction of the word vitamin into physiologic literature. The story of the abnormal behavior of pigeons kept on a diet of polished rice and their astounding recoveries when small amounts of certain supplementary foods or food "accessories" are added to the ration has become a classic. Subsequent experimentation has been directed, on the one hand, toward the discovery of the chemical nature of the potent agent, the antineuritic vitamin, and,
Adaptive sex-dependent changes in the zonation of carbohydrate and lipid metabolism in rat liver lobules after partial hepatectomy
Authors: Cornelis J.F. Van Noorden, Ilse M.C. Vogels, Jan James
Journal: Hepatology (1994)

To evaluate changes in metabolic heterogeneity in rat liver lobules after partial hepatectomy, we measured parameters of carbohydrate and lipid metabolism cytophotometrically in periportal and pericentral zones of livers of mature female and male rats. Glycogen content was shown to be always higher in pericentral zones than in periportal zones. After a rapid depletion of glycogen stores during the first 8 hr after partial hepatectomy, the levels were restored to normal after 24 hr, but a significant depletion was found again at 48 hr after operation. These fluctuations were similar in female and male rat livers. The lipid content in control rat livers was low and was mainly localized in periportal zones. Partial hepatectomy caused a significant increase in lipid content after 24 to 48 hr in periportal zones only, which was distinctly higher in female than in male rat livers. Activity of NADPH–producing glucose–6–phosphate dehydrogenase was heterogeneously distributed in lobules of female control rats with highest activity in pericentral zones, whereas a lower but evenly distributed activity was found in lobules of control male rats. The activity was not affected by partial hepatectomy in male rats, whereas the activity in female rat livers decreased to levels found in male rats at 24 to 48 hr after operation. Another NADPH–producing enzyme, malate dehydrogenase, showed the highest activity pericentrally in female rats, and a low activity was evenly distributed in male rats. The activity did not change significantly after partial hepatectomy. The ketogenic enzyme β–hydroxybutyrate dehydrogenase showed the highest activity in pericentral zones of control livers. The activity in male rat livers was almost twice as high as in female rat livers in both zones. Partial hepatectomy caused a distinct reduction in activity in both zones and both sexes, but the strongest reduction was found periportally. Alkaline phosphatase activity, which is linked with bile acid secretion by hepatocytes, was low in control male and female rats and was mainly found periportally. The activity was increased dramatically at 24 to 48 hr after partial hepatectomy in both zones and particularly in male rat livers. The index for the Krebs cycle, succinate dehydrogenase activity, was highest in periportal zones. At 24 to 48 hr after partial hepatectomy, this preferential zonation was lost, and the activity was slightly higher in pericentral zones. This reversal of zonation was found in all livers of female and male rats investigated. Because the metabolic changes after partial hepatectomy cannot be explained by hormonal changes that are known to occur after partial hepatectomy, we concluded that the metabolic zonation in rat liver lobules is dynamic, sex dependent and adaptive. (Hepatology 1994;20:714-724).
Moves beginning to approve new indications for aspirin use
Authors: J. Elliott
Journal: JAMA (1979)

Aspirin in daily doses of 1,300 mg is "safe and effective for reducing the risk of recurrent transient ischemic attacks in men who have had transient ischemia of the brain due to fibrin platelet emboli." With that pronouncement, a special advisory committee to the Food and Drug Administration has recommended that the official indications for aspirin be expanded to include therapy for certain types of transient ischemic attacks (TIAs) in men only. The recommendation of the FDA's Peripheral and Central Nervous System Drugs Advisory Committee, if accepted by the agency, "may substantially alter the way medicine is practiced," according to Ron Kartzinel, MD, director of the FDA's Division of Neuropharmacological Drugs. The action may also represent the first official step in what some believe may become a rush to confirm new uses for the 80-year-old drug, now known to inhibit synthesis of certain prostaglandins. "The committee was very careful," says
Immunohematologic Diseases
Authors: Lanny J. Rosenwasser
Journal: JAMA (1992)

TWO EVENTS revolutionized the field of immunohematology: the discovery of the ABO blood group system by Karl Landsteiner in 1900 and the development of the Coombs' test in 1945. These observations resulted in the improved safety and success of blood transfusions. Approximately 2% of hospitalized patients develop alloantibodies that are formed as a result of blood transfusions from heterologous donors or during pregnancy; this can lead to transfusion reactions or hemolytic disease of the newborn. Although it was initially thought that alloantibodies are formed only against erythrocyte antigens, it became evident that alloantibodies are also generated against various neutrophil (eg, NA1, NB1) and platelet (eg, P1<sup>A1</sup>, Bak<sup>a</sup>) antigens. Like erythrocyte alloantibodies, neutrophil and platelet alloantibodies can cause immune destruction of blood cells during transfusion reactions or pregnancy. Furthermore, immune destruction of erythrocytes, neutrophils, and platelets can occur when autoantibodies are produced against these cells, during drug therapy, or
Necrotizing Fasciitis
Authors: Jeffrey R. Fisher
Journal: JAMA (1979)

Twenty-six patients with necrotizing fasciitis were treated during a nine-year period. Twenty-one (81%) had diabetes mellitus and 19 (73%) had gas in their soft tissues from nonclostridial infection. Although crepitation was found by physical examination in only five patients, roentgenographic examination of the involved site disclosed gas in every patient in whom it was subsequently found at surgery. Previous studies have not used roentgenography to search for soft-tissue gas. The 21 diabetic patients in our series had a mortality of 19%, the lowest yet reported. This suggested that roentgenographic study of cases with fasciitis permits earlier diagnosis and favorably affects outcome. (<i>JAMA</i>241:803-806, 1979)
WHEN TO OPERATE AND WHEN TO USE RADIUM ON FIBROIDS OF THE UTERUS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
False porphobilinogen reactions in the urine of mental patients
Authors: L. Reio
Journal: JAMA (1969)

A false-positive reaction for urinary porphobilinogen (PBG) was observed in the untreated eluates obtained when the Mauzerall-Granick method was applied to urine samples of mental-hospital patients who were receiving phenothiazines. The interference may be derived from the phenothiazine medication given to the patients, either directly, or as one of the several possible metabolites, or from some singular dye constituent in the tablets. Two different chromatographic systems were designed to separate the possible interfering compound from PBG.
A phase I trial of IMC-A12 and temsirolimus in children with refractory solid tumors: A Children’s Oncology Group Study.
Authors: M. Fouladi, J. P. Perentesis, L. M. Wagner, A. M. Ingle, J. Gammon, G. Thomas, D. A. Krueger, P. Houghton, S. Vinks, B. Weigel, S. Blaney
Journal: Journal of Clinical Oncology (2011)

9520 Background: IMC-A12, a fully recombinant IgG1 monoclonal antibody that targets the human IGF-IR and inhibits downstream signaling of MAPK and PI3K/AKT, and temsirolimus, an mTOR inhibitor, have demonstrated single agent, antitumor activity against many pediatric cancer cell lines and xenograft models. A phase I trial evaluating the combination of these two agents was conducted in children with refractory solid and CNS tumors. Methods: Using a modified 3+3 design, IMC A12 and temsirolimus were administered intravenously once every 7 days in 28 day cycles. Serial PK studies were obtained on day 1, cycle 1 and trough samples were obtained on days 15 and 28. Biological studies included assessment of IGFR and insulin receptor expression and phosphorylation in archival tumor samples and phosphorylation of IGFR and mTOR downstream targets in peripheral blood mononuclear cells pre and post therapy. Results: Twenty-eight patients [16 males, median age 13 years (range 2-21)] with rhabdomyosarcoma (n=6), osteosarcoma (n=5), Ewing’s sarcoma (n=4), astrocytomas (n=3), medulloblastomas (n=2) or other tumors (n=8) were enrolled and 26 were evaluable for toxicity. At dose level 1 [IMC-A12 (6 mg/kg); temsirolimus (15 mg/m2)], 2 DLTs (grade 3 hypercholestrolemia and mucositis) occurred among 6 evaluable patients. Six more patients were accrued per study design and 3 additional DLTs were observed (grade 3 ALT, fatigue and prolonged thrombocytopenia > 14 days). At dose level 0 [IMC-A12 (6 mg/kg); temsirolimus (10 mg/m2)], dose-limiting mucositis occured in 2/6 patients. Doses of both agents were therefore decreased and at dose level -1 [IMC-A12, (4 mg/kg) and temsirolimus at (8 mg/m2)], 0 of 3 patients experienced a DLT. An intermediate dose level [IMC-A12 (6 mg/kg) and temsirolimus (8 mg/m2)] is completing evaluation. Conclusions: The recommended pediatric phase II doses of IMC-A12 and temsirolimus administered in combination are much lower than the single agent phase II doses. PK and PD data are currently being analyzed.