tbuckley/cabot-search huggingface dataset:
The Clinical Usefulness of ACTH and Cortisone
Authors: George W. Thorn, Peter H. Forsham, Thomas F. Frawley, S. Richardson Hill, Marcel Roche, Dietrich Staehelin, D. Laurence Wilson
Journal: New England Journal of Medicine (1950)

OVER the past two decades reports on the beneficial effects of adrenocortical extracts in such varied disorders as pemphigus,1 vomiting of pregnancy2 and disturbances of neuromuscular function have appeared.3 Improvement, although often encouraging, was usually transient and difficult to reproduce. The high cost of adrenal extracts and their relatively low potency made it impractical to use pharmacologically effective doses of hormone for prolonged periods. Furthermore, in patients with normal adrenal glands there was the added difficulty of compensating for the suppression of pituitary adrenocorticotrophic hormone (ACTH) production that accompanies the administration of biologically active adrenocortical steroids. These difficulties are best . . .
Lethal hepatic necrosis after therapy with imipramine and desipramine
Authors: W. J. Powell
Journal: JAMA (1968)

An apparently allergic reaction manifested by exfoliative dermatitis, mucous membrane desquamation, eosinophilia, severe hepatitis, and death occurred in an 80-year-old woman after therapy with imipramine hydrochloride and desipramine hydrochloride. Autopsy showed massive central and midzonal hepatic necrosis. To the authors' knowledge this is the first report of a lethal hepatic hypersensitivity reaction following administration of these drugs.
Runner's ability depends partly on muscle fiber type
Authors: P. Gunby
Journal: JAMA (1979)

Anticipation of the 13th Winter Olympics sets the stage for a renewed interest in the physiology of the athletic experience. At Ball State University, Muncie, Ind, for example, researchers are studying the fiber composition of leg muscles and how this affects a runner's chances for top-level competitive success. In a recent seminar at the University of Chicago Pritzker School of Medicine, David L. Costill, PhD, a marathoner by avocation, professor of physical education and biology, and director of the Human Performance Laboratory at Ball State, explained some of the new approaches being taken at the laboratory. It has been known for a decade that human skeletal muscle is composed of at least two fiber types. More recently Costill and others have been looking at the distribution of these fibers as a factor in running ability. Using a needle biopsy technique, researchers take 10 to 20 mg of muscle from the
FURTHER COMMUNICATION ON A CURE FOR TUBERCULOSIS.
Authors: PROFESSOR R. KOCH
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Potential role of hepatic macrophages in neutrophil-mediated liver injury in rats with sepsis
Authors: F Doi
Journal: Hepatology (1993)

We investigated the pathogenesis of septic liver injury in rats caused by cecal ligation and puncture. In this model, numerous neutrophils accumulated in the liver in parallel with the development of liver dysfunction. The supernatants of hepatic macrophages isolated from these septic rats 24 hr after cecal ligation and puncture had enhanced chemotactic activities for human neutrophils. These results suggest that in sepsis, hepatic macrophages attract neutrophils to the liver. Human neutrophils preincubated in this macrophage supernatant had the following biological activities not seen in the sham-operated controls. (a) They became more adherent to cultured endothelial cells through up-regulation of adhesion molecules such as CD11b/CD18, (b) their chemiluminescence was markedly elevated. These functional changes of cecal ligation and puncture hepatic macrophages were the same as those in endotoxin-pretreated hepatic macrophages after isolation from normal rats. Therefore we suspect that hepatic macrophages are activated by portal vein endotoxin in sepsis. These activated hepatic macrophages secreted chemical mediators of inflammation, including leukotriene B4 and tumor necrosis factor. In conclusion, hepatic macrophages seem to interact closely with neutrophils and play an important role in the pathogenesis of septic liver injury. (HEPATOLOGY 1993;17:1086–1094.)
Toxic effects of marine plywood
Authors: G. Gidseg
Journal: JAMA (1985)

<h3>In Reply.—</h3> Ms Dresser's comments raise three issues: the scope of our study, the possibility of selection bias, and the similarities in the phenomena of obligatory running and anorexia nervosa. I agree with Dresser's first point, that our study did not investigate all of the many potential relationships between obligatory running and anorexia nervosa. However, we never claimed to have performed the definitive study on obligatory running and anorexia nervosa. Our study was simply a test of the assertion by Yates et al<sup>1</sup>that the two groups "seemed to share certain measurable personality characteristics" including denial, introversion, depression, and discomfort with the expression of anger. Our selection of the Minnesota Multiphasic Personality Inventory was based on its widespread use in clinical and research settings and its proven reliability and validity in assessing these very traits. While the observations and speculations by Yates et al were interesting, it is essential
NCOG-14. HIPPOCAMPAL N-ACETYLASPARTATE CONCENTRATION CORRELATES TO VERBAL MEMORY BEFORE RADIOTHERAPY FOR BRAIN METASTASES
Authors: Radim Jancalek, Martin Bulik, Tomas Kazda
Journal: Neuro-Oncology (2018)

Changes of quality of life and cognitive function, especially verbal memory, after brain radiotherapy is currently widely discussed in neurooncology with substantial change in the paradigm of treatment of brain metastases. In our previous study, we described the decrease in the hippocampal concentration of N-acetylaspartate (NAA, marker of neuronal density and viability) in response to whole brain radiotherapy (WBRT). The aim of presented analysis is to evaluate the NAA concentration before radiotherapy and to describe the relation to the verbal memory baseline. MATERIAL AND Patients with brain metastases indicated to WBRT underwent hippocampal MR spectroscopy (MRS) along with neuropsychological examinations focused among others to verbal memory. Absolute NAA concentrations for right and left hippocampus and the sum of absolute NAA concentrations in both hippocampi were compared with results of AVLT_TR. The examination was performed in 26 patients. Patients were divided into two groups based on median NAA concentration (8.56 mM). The median AVLT_TR was 37 points in the group with hippocampal NAA concentration ˂ 8.56 mM. In the group of patients with baseline NAA concentration ≤ 8.56 mM, the median AVLT_TR was higher with 43 points (Mann-Whitney U Test, p = 0.02). Non-invasive examination by hippocampal MRS can predict the baseline pre-radiotherapy cognitive functions, which are normally tested by time-consuming psychological tests. Patients who had lower baseline NAA hippocampal concentrations had a significantly lower baseline verbal memory. NAA hippocampal concentrations may be a useful biomarker for selecting patients who would benefit most from the hippocampal sparing radiotherapy techniques reducing the risk of iatrogenic deterioration of QoL in patients treated with a palliative intent, especially in cases where local brain stereotactic radiotherapy is not applicable or available. Supported by the Ministry of Health of the Czech Republic, grants NV18-03-00469, NV18-03-00398.
Questions and Answers
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DISPENSARY EVIL.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME CHRISTMAS REFLECTIONS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rape Victimology
Authors: Natalie Shainess
Journal: JAMA (1975)

<i>Rape Victimology</i>is an important and long overdue volume. At last: a book on rape that has compassion for the victims, pays attention to social and legal issues, and makes recommendations that are both valid and valuable. Furthermore, it is well written and readable. Its format could not be improved on. The atmosphere is set by the rape victim speaking out. The book then proceeds to social, legal, and sociomedical aspects of rape victimization, adding the special area dealing with the child as sex victim and then turning to policy. It makes the important point that our dating system between men and women is "a mutually exploitative arrangement of sex-role expectations which limit and direct behavior of both parties.... The man is taught to anticipate a sexual return on his financial and social investment." From this baseline, some aspects of rape are derived. If here and there a satirical note
Lithium carbonate toxicity
Authors: F. A. Herrero
Journal: JAMA (1973)

Lithium carbonate therapy, uncomplicated by other factors, can give rise to a deep coma even if the serum levels of lithium are within the desired range. A patient with manic depressive disease, having been treated with lithium carbonate for less than a year, developed progressive impairment of consciousness. A few days after the medication was discontinued, the patient had a slow but complete recovery. Lithium accumulation in the brain is postulated.
Myelodysplasia
Authors: Mark L. Heaney, David W. Golde
Journal: New England Journal of Medicine (1999)

The myelodysplastic syndromes are clonal hematologic disorders characterized clinically and morphologically by ineffective hematopoiesis. The natural history of these syndromes ranges from a chronic course that may span years to a rapid course of leukemic progression. Unfortunately, the nomenclature and classification systems used to describe these conditions are cumbersome and contentious. Nonetheless, myelodysplastic syndromes are viewed by most hematologists as encompassing stages of neoplastic hematopoiesis associated with cytopenias and as excluding nonneoplastic conditions. In general, myelodysplastic conditions are preleukemic disorders in which the neoplastic clone is established, but not all cases of myelodysplasia terminate in acute myeloid leukemia (AML). Here, . . .
Myasthenic reaction to colistimethate
Authors: G. N. Gold
Journal: JAMA (1965)

<h3>To the Editor:—</h3> After reading the article by Parisi and Kaplan (<b>194</b>: 298,1965) describing apnea, muscle weakness, and ptosis in association with colistimethate therapy, we feel obligated to caution physicians that neuromuscular effects due to this drug may be quite common. We recently saw a patient who repeatedly developed episodes of ptosis and profound muscular weakness of the extremities in response to small doses (75 mg every 12 hours) of sodium colistimethate. Her renal function was normal, and the maximum blood level of the drug was 2μgm/ml. This value is within or below the recommended therapeutic range. Edrophonium, 10 mg, administered intravenously improved her extremity weakness, but had no effect on her facial weakness. Fortunately, toxicity due to the colistimethate was considered, and she became asymptomatic when the antibiotic was discontinued. It is conceivable that had this patient received the customary dose of the drug (300 mg), or had there
Detergent Hazards
Authors: Walter L. Schleyer
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In the Aug 28, 1972, issue ofThe Journal, Drs. Feldman, Rail, and Moore reported studies of detergent effects on the rabbit eye. Since detergent phosphate is quite innocuous compared to more alkaline detergency builders, a concern has arisen that legal restrictions on the use of phosphate would result in more hazardous household detergents. Studies such as the one reported by the authors from the National Institutes of Health are being undertaken in order to demonstrate such effects and to substantiate public warning statements by the Surgeon General and other health officials. On more thorough examination of safety aspects, the household detergent issue is not that simple. The authors assert that household laundry and dishwasher detergents fall into three general categories, namely, those containing principally either phosphate, carbonate, or metasilicate. Had they provided the chemical analyses of their detergent materials, this premise could be seen to lack
Ultrasound Increases Plasmid-Mediated Gene Transfer to Dystrophic Muscles without Collateral Damage
Authors: G DANIALOU, A COMTOIS, R DUDLEY, J NALBANTOGLU, R GILBERT, G KARPATI, D JONES, B PETROF
Journal: Molecular Therapy (2002)

Studies have shown that ultrasound, used either alone or in combination with microbubble contrast agents, can increase cell membrane permeability to plasmid DNA. Because ultrasound is a non-painful and well-established tool in clinical medicine, its potential to enhance DNA uptake into the muscles of patients with muscular dystrophy is conceptually attractive. Therefore, we evaluated the ability of ultrasound pulses (1 MHz; 1.5 W/cm2) to increase exogenous (LacZ) gene expression in normal wild-type and dystrophic Dmdmdx/mdx mice after plasmid DNA injection into muscle. We also ascertained whether co-injection of lipid-encapsulated perfluoropropane microbubbles (Definity) or pretreatment with hyaluronidase could further increase the level of gene transfer to ultrasound-treated muscles. The use of ultrasound did not increase transfection efficiency in normal mice. In contrast, dystrophic mice demonstrated an increase in the number of transfected fibers (threefold) as well as the amount of LacZ protein (22-fold) after ultrasound exposure, provided that Definity was also co-injected with the DNA. Pretreatment of muscles with hyaluronidase before ultrasound exposure was not effective in augmenting the level of gene transfer. Under the optimal conditions for dystrophic muscle transfection (ultrasound + Definity), there was no associated increase in muscle damage. Hence ultrasound may provide a safe and effective method for enhancing gene transfer to dystrophic muscles, thereby increasing the prospects for therapeutic application of naked DNA in muscular dystrophy patients.
Pregnancies after surgical correction of tetralogy of Fallot
Authors: J. H. Ralstin
Journal: JAMA (1976)

A PATIENT had successful correction of the tetralogy of Fallot and then had five pregnancies without incident. <h3>Report of a Case</h3> A 34-year-old housewife was first noted to have decreased exercise tolerance, exertional squatting, and cyanosis at the age of 2 years, when she began walking. By 6 years of age, her symptoms were severe, and at the age of 10 years her education was terminated because she was unable to climb stairs at school. She remained sedentary at home until her late teens, when her condition had improved enough for her to work part-time as a waitress. At the age of 23, she was admitted to the University of Kansas Medical Center because of progressively decreasing exercise tolerance. She was 157 cm tall, and weighed 60 kg. She was cyanotic and had clubbing of fingers and toes. A grade III/IV pulmonary systolic ejection murmur and only an aortic component
Invasive Group A Streptococcal Infections-United Kingdom, 1994
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship Between Patient Mortality and Nurses' Level of Education
Authors: George R Boggs
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Echocardiographic evaluation of the Jarvik 2000 axial flow pump Mihai Croitoru, Oscar H Frazier, Robert Jarvik, Branislav Radovancevic, Antonieta Hernandez, Sue Maisey, Timothy Myers, Tehreen Khan, Igor D Gregoric, Raymond F Stainback. St. Luke's Episcopal Hospital/Texas Heart Institute, Houston, TX
Journal: Journal of the American College of Cardiology (2001)