tbuckley/cabot-search huggingface dataset:
Risk of suicide among persons with AIDS. A national assessment
Authors: T. R. Cote
Journal: JAMA (1992)

<h3>Objective.</h3> —We sought to describe the rate, risk, trends, methods, and distribution of suicide among persons with the acquired immunodeficiency syndrome (AIDS) in the United States. <h3>Design.</h3> —We used National Center for Health Statistics multiple-cause mortality data from 1987 through 1989 to identify suicides among persons with AIDS (PWAs) and public-access AIDS surveillance data to determine person-years of observation of PWAs. <h3>Patients.</h3> —Residents of the United States with death certificates indicating suicide. <h3>Main Outcome Measure.</h3> —Death certificates indicating both AIDS and suicide. <h3>Results.</h3> —In 1987 through 1989, a total of 165 suicides among PWAs occurred in 45 states and the District of Columbia. All but one case were male. Among males the rate was 165 per 100000 person-years of observation, 7.4-fold higher than among demographically similar men in the general population. Self-poisoning with drugs was both the most common method (35%) and the method with the highest standardized mortality ratio (35). Suicide risk for PWAs decreased significantly (<i>P</i>&lt;.05) from 1987 to 1989. <h3>Conclusion.</h3> —Persons with AIDS have an increased risk of suicide, and assessment of such risk should be a standard practice in their care. These assessments should be carefully considered when potentially lethal medications are prescribed. The declining trend in suicide rates between 1987 and 1989 is encouraging; possible causes include emerging therapies for human immunodeficiency virus/AIDS, better psychiatric care for these patients, and lessened social stigma against PWAs. (<i>JAMA</i>. 1992;268:2066-2068)
NONPANCREATIC TUMORS AND HYPOGLYCEMIA
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatology Highlights
Authors: Nicholas Russo, Robert S. Brown, Russell Rosenblatt, Robert E. Schwartz, Shawn Shah, Clara Tow, Nicole T. Shen, Saurabh Mukewar, Vikas Gupta, Aleksey Novikov
Journal: Hepatology (2018)

Russo, Nicholas; Brown, Robert S. Jr; Rosenblatt, Russell; Schwartz, Robert E.; Shah, Shawn; Tow, Clara; Shen, Nicole T.; Mukewar, Saurabh; Gupta, Vikas; Novikov, Aleksey Author Information
Iron "Undercontamination"?
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HLA-C genes and susceptibility to type 1 autoimmune hepatitis
Authors: M Strettell
Journal: Hepatology (1997)

Susceptibility to autoimmune hepatitis (AIH) is associated with the HLA A1-B8-DR3 haplotype, DR4 antigen, and, more specifically, the HLA DRB3*0101, DRB1*0301, and DRB1*0401 alleles. Few investigators, however, have examined the HLA C locus in AIH, which warrants detailed study in view of its recently described roles in immunoregulation. Eighty-seven adult, white patients with well-characterized type 1 AIH and 100 controls were studied. HLA C and HLA DRB1 alleles were assigned by polymerase chain reaction (PCR)-based genotyping. HLA A and B antigens were determined by standard microlymphocytotoxicity assay. Extended haplotypes were constructed according to known patterns of linkage disequilibrium. Only one HLA C locus allele, Cw*0701, which was present in 54% of patients versus 34% of controls (P = .006; relative risk [RR] = 1.54) was associated with AIH. The overall increase in the frequency of the Cw*07 gene (70.1% of patients vs. 54% of controls; P = .024; RR = 1.3) was due entirely to inheritance of the Cw*0701 allele rather than the other Cw*07 alleles, Cw*0702, *0703, and *0704. The RR for Cw*0701 (RR = 1.54) is greater than that for HLA A1 (RR = 1.33) and DRB1*0301 (RR = 1.49), but less than that for HLA-B8 (RR = 1.75). The present findings suggest that the gene or genes conferring susceptibility to AIH lie in the region centromeric to the HLA A locus between HLA C and DRB1. Although linkage disequilibrium with both B8 and DRB1*0301 may account for our finding of an increased frequency of Cw*0701, it is also possible that this allele contributes to disease susceptibility, perhaps by interaction with natural killer cells or cytotoxic T lymphocytes.
Lack of clopidogrel pretreatment effect on the relative efficacy of bivalirudin with provisional glycoprotein IIb/IIIa blockade compared to heparin with routine glycoprotein IIb/IIIa blockadeA REPLACE-2 substudy
Authors: J SAW, A LINCOFF, W DESMET, A BETRIU, W RUTSCH, R WILCOX, N KLEIMAN, K WOLSKI, E TOPOL
Journal: Journal of the American College of Cardiology (2004)
THE SECTIONS, ETC.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessment of Inadequately Filtered Public Drinking Water—Washington, D.C., December 1993
Journal: JAMA (1994)

The risk for waterborne infectious diseases increases when filtration and other standard water-treatment measures fail. On December 6, 1993, water-treatment plant operators in the District of Columbia (DC) began to have difficulty maintaining optimal filter effectiveness. On December 7, filter performance worsened, and levels of turbidity (i.e., small suspended particles) exceeded those permitted by U.S. Environmental Protection Agency (EPA) standards. On December 8, DC residents were advised to boil water intended for drinking because of high municipal water turbidity that may have included microbial contaminants. Although adequate chlorination of the DC municipal water was maintained throughout the period of increased turbidity, the parasite Cryptosporidium parvum is highly resistant to chlorination. Because of the increased risk for infection with this organism and other enteric pathogens, the DC Commission of Public Health and CDC conducted four investigations to determine whether excess cases of diarrheal illness occurred because residents drank inadequately filtered water. This report describes the results of these investigations.
Breast cancer treated with fluorouracil. Survival studies in advanced stages
Authors: R. J. Samp
Journal: JAMA (1966)

The addition of fluorouracil (5-FU) to standard, palliative antitumor measures for 144 female patients with breast cancer in advanced stages resulted in an average increased survival of 6 to 17 months when compared by subgroups with 127 control cases on standard therapy only during the period immediately preceding the introduction of fluorouracil chemotherapy. All cases have confirmed tissue diagnosis of breast cancer and complete follow-up data. Comparison of survival by subgroups according to age, cancer-free interval between initial therapy and recurrence, sites of metastases, menopausal "age" at the time of dissemination, 50% survival points, and combinations of these significantly favors patients treated with fluorouracil. Furthermore, the use of fluorouracil does not preclude nor contraindicate other and further therapies if and when the tumor reactivates, because further survival time is possible after fluorouracil therapy.
Bilateral Chronic Infection of the Glands of Montgomery: Report of a Case
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ENDOCRINOLOGY
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Himself.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic Radiology
Authors: Juan A. del Regato
Journal: JAMA (1981)

<h3>The Radiotherapist</h3> A 20th-century medical specialty, radiotherapy is almost exclusively concerned with the treatment of malignant tumors; hence, its frequent designation as "radiation oncology." Practiced initially by surgeons or as a sideline to radiodiagnosis, therapeutic radiology has developed into a vigorous and indispensable clinical specialty. The American Board of Radiology has certified its practitioners as distinct specialists, from its inception in 1934; in 1980, a total of 91 candidates passed the examinations and were certified by the board. The number is insufficient to satisfy the demand for skillful radiotherapists. Organized training programs for radiotherapists were not available in the United States for a long time. In 1981, three hundred seventy-two residents are receiving training in radiation oncology in 88 different institutions. Such training programs require the availability of varied and costly equipment, skillful medical and ancillary personnel, a large and varied volume of cancer patients, hospitalization and other clinical facilities,
Total Hip-Joint Replacement in the United States
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
影响不同类型表皮坏死松解症死亡率的因素(药物反应)
Authors: C. Traikia, C. Hua, L. Le Cleach, N. Prost, F. Hemery, T. Bettuzzi, O. Chosidow, P. Wolkenstein, S. Ingen‐Housz‐Oro, E. Sbidian
Journal: British Journal of Dermatology (2020)

中毒性表皮坏死松解症(也称为 TEN 或 Lyell 综合征)是药物过敏的一种破坏性类型。每百万人中仅有一两人受累,但往往是致死性的。患者超过 30% 的皮肤迅速丢失(称为皮肤脱落),并出现眼、口和生殖器等膜水疱。史蒂芬斯‐强森症候群 (SJS) 相似,但皮肤脱落率低于 10%,术语 SJS/TEN 重叠综合征是指皮肤脱落率为 10‐29% 的综合征。 我们知道,年龄较大、皮肤脱落较多和患有其他疾病的患者更容易死亡,但我们不知道死亡率是否也取决于他们接受治疗的地方。 这些病症的管理(诊疗护理)非常复杂,涉及许多不同的专业,如皮肤科、眼科和口腔医学,很少有医院所治疗的患者数量足以获取这一领域的知识。 这项研究使用了年龄超过 15 岁的患者的国家数据,这些患者从 2010 年 1 月开始在法国医院接受了为期 5 年的治疗。在 300 家医院就诊的 991 例患者中,60% 有 SJS,17% 有 SJS/TEN 重叠,23% 有 TEN。 共有 109 例 (11%) 患者死亡:9 例 (2%) 有 SJS 、26 例 (15%) 有 SJS/TEN 重叠和 74 例 (33%) 有 TEN。五年期间每家医院的病例数为 1 例到 70 例以上不等,病例较多的医院生存率明显较好。医院间转院不影响死亡率。 作者得出结论,SJS 和 TEN 患者应转诊至具有更多管理这些病症经验的中心。 本摘要涉及研究:与表皮坏死松解症死亡率相关的个体层面和医院层面因素:一项法国全国性多层次研究(2012‐2016)
ORTHOSCOPE: An Automatic Web Tool for Phylogenetically Inferring Bilaterian Orthogroups with User-Selected Taxa
Authors: Jun Inoue, Noriyuki Satoh
Journal: Molecular Biology and Evolution (2018)

Identification of orthologous or paralogous relationships of coding genes is fundamental to all aspects of comparative genomics. For accurate identification of orthologs among deeply diversified bilaterian lineages, precise estimation of gene trees is indispensable, given the complicated histories of genes over millions of years. By estimating gene trees, orthologs can be identified as members of an orthogroup, a set of genes descended from a single gene in the last common ancestor of all the species being considered. In addition to comparisons with a given species tree, purposeful taxonomic sampling increases the accuracy of gene tree estimation and orthogroup identification. Although some major phylogenetic relationships of bilaterians are gradually being unraveled, the scattering of published genomic data among separate web databases is becoming a significant hindrance to identification of orthogroups with appropriate taxonomic sampling. By integrating more than 250 metazoan gene models predicted in genome projects, we developed a web tool called ORTHOSCOPE to identify orthogroups of specific protein-coding genes within major bilaterian lineages. ORTHOSCOPE allows users to employ several sequences of a specific molecule and broadly accepted nodes included in a user-specified species tree as queries and to evaluate the reliability of estimated orthogroups based on topologies and node support values of estimated gene trees. A test analysis using data from 36 bilaterians was accomplished within 140 s. ORTHOSCOPE results can be used to evaluate orthologs identified by other stand-alone programs using genome-scale data. ORTHOSCOPE is freely available at https://www.orthoscope.jp or https://github.com/jun-inoue/orthoscope (last accessed December 28, 2018).
A Phase II Study of Erlotinib Monotherpay in Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC) without EGFR Gene Mutation Who Have Never/Light Smoking History: NEJ006/TCOG0903
Authors: M. Maemondo, Y. Ishii, Y. Demura, K. Okudera, K. Takamura, N. Morikawa, M. Harada, O. Ishimoto, K. Kobayashi, Y. Saijo
Journal: Annals of Oncology (2012)
Sexual Differentiation of the Brain: A Model for Drug-Induced Alterations of the Reproductive System
Authors: Roger A. Gorski
Journal: Environmental Health Perspectives (1986)

The process of the sexual differentiation of the brain represents a valuable model system for the study of the chemical modification of the mammalian brain. Although there are numerous functional and structural sex differences in the adult brain, these are imposed on an essentially feminine or bipotential brain by testicular hormones during a critical phase of perinatal development in the rat. It is suggested that a relatively marked structural sex difference in the rat brain, the sexually dimorphic nucleus of the preoptic area (SDN-POA), is a morphological signature of the permanent or organizational action of estradiol derived from the aromatization of testicular testosterone. The SDN-POA of the male rat is severalfold larger in volume and is composed of more neurons than that of the female. The observation that the mitotic formation of the neurons of the SDN-POA is specifically prolonged has enabled us to identify the time course and pathway of neuronal migration into the nucleus. Study of the development of the SDN-POA suggests that estradiol in the male increases the number of neurons which survive a phase of neuronal death by exerting a neurite growth promoting action and/or a direct neuronotrophic action. It may not be possible to extrapolate this trophic effect of estradiol to all other structural sex differences since in the anteroventral periventricular nucleus, steroid exposure reduces the number of immunohistochemically defined dopaminergic neurons. Finally, although it is clear that gonadal hormones have dramatic permanent effects on the brain during perinatal development, even after puberty and in adulthood gonadal steroids can alter neuronal structure and, perhaps as a corollary to this, have permanent effects on reproductive function. For example, in the lightly androgenized rat which exhibits the delayed anovulation syndrome, exposure to estrogen prepubertally delays the onset of ovulatory failure, whereas estrogen exposure peri- or post-pubertally has an inhibitory effect on ovulation. Although the brain may be most sensitive to gonadal hormones or exogenous chemical factors during perinatal development, such sensitivity does not appear limited to this period.
Prevention of Background Staining of Starch Gels. Preliminary Treatment of the Starch with Streptomyces Griseus Protease
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal