tbuckley/cabot-search huggingface dataset:
Cervical Intraepithelial Neoplasia, Cervical Cancer, and HPV
Authors: E. A. Holly
Journal: Annual Review of Public Health (1996)

Major progress has been made to control cervical cancer in the United States and Europe using screening programs, although it remains a major cause of morbidity and mortality in the developing world. The association between cervical cancer and a sexually transmissible etiologic agent was hypothesized long before identification of human papillomaviruses (HPV) as agents that infected the genital tract. HPVs are among the most common sexually transmitted agents and have been shown to induce several squamous anogenital cancers, including squamous cell cancer of the cervix. After an etiologic role for HPV was identified in cervical cancer and CIN, efforts to understand the molecular biology of HPV were greatly expanded, enhanced by the advent of deoxyribonucleic acid (DNA) probes to identify HPV infection. Recent research has focused on specific types of HPV in relation to other recognized risk factors in the pathogenesis of CIN and invasive cervical cancer.
Prophylactic lidocaine in acute MI
Authors: George R. Reiss
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Hellinger et al<sup>1</sup>state that "the validity of the chronic mononucleosis syndrome and the appropriate means for its diagnosis have not been established." I would like to add a proviso. Since there were no data presented in this study that either prove or disprove the "validity" of the syndrome itself, the authors should refrain from drawing such a conclusion. This article only addresses the value of Epstein-Barr virus serology in the diagnosis of chronic mononucleosis, also known as chronic fatigue syndrome. Others have reached similar conclusions in the past.<sup>2</sup> These results could be interpreted to show that the testing available today is simply not sensitive enough to help diagnose this illness. They also suggest that laboratory testing for chronic fatigue syndrome, in itself, is no substitute for careful history taking, examination, and differential diagnosis.
STMC-08. ACTIN CYTOSKELETON REGULATOR ARP2/3 COMPLEX IS REQUIRED FOR DLL1 ACTIVATING NOTCH1 SIGNALING TO MAINTAIN THE STEM CELL PHENOTYPE OF BRAIN TUMOR INITIATING CELLS
Authors: Chen Zhang, Xuejun Yang
Journal: Neuro-Oncology (2016)

Glioblastoma (GBM) is the most common and lethal primary intracranial tumor. Actin cytoskeleton regulator ARP2/3 complex modulates glioma cell invasion and migration. Besides, inside the tumor entity contains brain tumor initiating cells (BTICs), which are resistant to chemical and radiation therapies and form recurrent tumor. It has been shown that NOTCH signaling is essential for BTICs to maintain the stem cell phenotype. But little is known regarding the role of actin cytoskeleton in NOTCH signaling and the stem cell phenotype maintenance. Here, we show ARP2/3 complex is required for NOTCH ligand DLL1 to activate NOTCH1 signaling, thus maintaining the stem cell phenotype. CD133-positive glioma cells co-expressed NESTIN and DLL1, and exhibited high NOTCH1 activity both in specimens and in vitro U87-MG and U251-MG glioma neurospheres. Silencing DLL1 decreased NOTCH1 activity as well as BTICs markers CD133 and NESTIN expression in both glioma neurospheres. Self-renewal ability was also impaired in DLL1 knockdown cells detected through single-cell neurosphere formation assay. Both ARP2/3 complex specific inhibitor CK636 and silencing subunit ARP2 induced the same effect with DLL1 knockdown. Subcellular fractionation experiments showed that membrane protein DLL1 was less expressed on the cell membrane of ARP2/3 inhibited and knockdown cells than untreated cells. An original method was introduced to study the expression pattern among cells inside the sphere. It showed that DLL1 was accumulated in the cytoplasm of the treated cells detected by confocal immunofluorescence microscope, which suggests that ARP2/3 complex regulates the transportation of DLL1 from cytoplasm to membrane to activate NOTCH1 receptor through cell contact. In vivo, silencing ARP2 also impaired the tumorigenicity of U87-MG neurosphere cells. These findings indicate that actin cytoskeleton protein participates in the stem cell phenotype maintenance, which provides evidence that anti-invasive targeted therapies may help eliminate BTICs.
Immunoaugmentative therapy
Journal: JAMA (1988)

<h3>To the Editor. —</h3> As president of the IAT Patients' Association, I must take issue with the validity of the DATTA report on immunoaugmentative therapy (IAT) published in the June 17 issue of<i>JAMA.</i><sup>1</sup>I am in complete agreement with the section of the accompanying editorial by the Food and Drug Administration's Dr Nightingale<sup>2</sup>correctly pointing out the inherent uselessness of a poll of experts evaluating therapies for which no published data for efficacy currently exist. I am concerned by<i>JAMA</i>'s decision to publish such a meaningless surveyand accompanying report, which only serves to fan the flames of emotionalism that have surrounded the use of IAT since 1974. It is especially unwelcome now as the Office of Technology Assessment moves forward with its design of a protocol for the formal evaluation of IAT, which will begin to resolve questions regarding safety and efficacy. I would think the
A Practice of Anaesthesia
Authors: Leroy D. Vandam
Journal: JAMA (1966)

<i>A Practice of Anaesthesia</i>is unlike any other book in the field, in breadth and depth of coverage of material, arrangement of subjects, and the uniformity of style of its contributors (all of whom are from the anesthesia department of St. Thomas' Hospital in London). Not a textbook in the usual sense of an instruction manual, it is a portrayal of anesthetic practice in the broadest sense. The second edition is at least as good as the first, and lives up to the promise of incorporating most of the advances in related fields during the past several years. Admittedly it is directed toward the advanced student, one seeking the Fellowship in the Faculty of Anaesthetists (or the American equivalent, the diploma of the American Board of Anesthesiology). In this respect, the everyday practitioner and even the diplomate of 10 or 15 years ago may find the reading heavy going. It
Asthma: Study in Prognosis of 1,000 Patients
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mental Disorder
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
From the NIH. Consensus statement on 'mood disorders: pharmacologic prevention of recurrences'
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urology
Authors: Peter C. Albertsen
Journal: JAMA (1996)

Controversy surrounding the early detection and management of prostate cancer continues to dominate the field of urology. During the past several years, prostate cancer screening using serum prostate-specific antigen (PSA) testing has become widespread in the United States. Although the American Cancer Society and the American Urological Association recommend that men older than 50 years undergo annual screening with a digital rectal examination and a serum PSA measurement, the US Preventive Services Task Force, the Canadian Task Force on the Periodic Health Examination, and the Canadian Urological Association do not support this practice.<sup>1</sup>Four important questions related to this controversy were addressed by researchers in 1995: What is responsible for the rising incidence of prostate cancer? What are the test performance characteristics of serum PSA, and can they be improved? Does early detection improve outcomes? What is the net benefit and cost of widespread screening to society? In 1995,
Symptomatic care of patients with amyotrophic lateral sclerosis
Authors: R. A. Smith
Journal: JAMA (1975)

Until a definitive treatment is found for amyotrophic lateral sclerosis, there will continue to be a need to provide symptomatic care. Experience with caring for a large number of patients has proved that symptomatic therapy can be based on rational principles. Treatment should be limited to procedures that are simple and low-cost, with low risk of serious morbidity. When all remedies fail, the physician can still provide a comforting presence and foster a dignified death. (<i>JAMA</i>234:715-717, 1975)
Pulmonary Vascular Lesions in Systemic Scleroderma
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bilateral adrenal myelolipomas with Cushing's syndrome
Authors: H. A. Kanj
Journal: JAMA (1988)

A 24-year-old woman with non—pituitary dependent Cushing's syndrome was found to have bilateral adrenal myelolipomas at surgery. These benign tumors consist of bone marrow and fat and are uncommon incidental findings that are discovered by computed tomography. Myelolipomas have rarely been associated with Cushing's syndrome, but the cause of the syndrome has not always been defined, because the reports preceded modern diagnostic methods. Careful examination of the adrenal glands from our patient showed a fusion of myelolipoma elements and adrenal cells without distinct adenomas or the typical nodular pattern of adrenal hyperplasia. This report suggests that adrenal myelolipomas and atypical hyperplasia of the zona fasciculata may be anatomically and functionally related. (<i>JAMA</i>1988;259:3034-3036)
Oysters and Bacteria.
Authors: None W. H.
Journal: JAMA (1899)

London, Eng., Feb. 25, 1899. <h3>To the Editor:</h3> —The committee upon the relation between oysters and disease which was appointed three years ago, has just made its final report to the Royal Society through two of its members, Professors Herdman and Boyce, and while their preliminary conclusions and partial reports have already been discussed in our columns (videJournal, p. 1484, 1898), complete findings seem of such interest as to merit further comment. The chief interest centers in the bacteriologic part of the report, in view of the bad name which has been given to oysters of late years as carriers of typhoid fever. Although Drs. Herdman and Boyce found no typhoid bacilli in any of the oysters they examined, due partly at least to the fact that they did not succeed in obtaining any from beds known to be contaminated by sewage or suspected of typhoid, yet there was
Hypnotic drugs and treatment of insomnia
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostication of hepatocellular carcinoma under sorafenib: external validation of the PROSASH-II model
Authors: Vito Sansone, Francesco Tovoli, Andrea Casadei-Gardini, Giovan Giuseppe Di Costanzo, Giulia Magini, Rodolfo Sacco, Tiziana Pressiani, Franco Trevisani, Raffaella Tortora, Luca Ielasi, Alessandro Granito
Journal: Journal of Hepatology (2020)
Clinical utility of CLIA-grade AR-V7 testing in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).
Authors: Mark Christopher Markowski, John Silberstein, James R. Eshleman, Jun Luo, Emmanuel S. Antonarakis
Journal: Journal of Clinical Oncology (2017)

183 Background: The AR-V7 splice variant may confer resistance to AR-targeted therapies but not taxane chemotherapies. Since August 2015, a clinical-grade assay to detect AR-V7 mRNA expression in circulating tumors cells (CTC) has been available through a CLIA-certified lab at Johns Hopkins. In the first 12 months after launch, 195 AR-V7 tests were ordered for clinical purposes. We contacted the ordering providers of the first 100 tests using a questionnaire-based survey to determine how (and if) the results of AR-V7 testing were used in clinical practice. Methods: We identified 100 consecutive mCRPC pts who underwent AR-V7 testing in our CLIA lab. Ordering providers received a questionnaire for each test ordered, asking how (and if) the results of the assay affected their clinical decision-making, and whether a PSA 50 response was obtained on next-line therapy after AR-V7 testing was performed. Results: 80 of 100 questionnaires were completed by 26 providers from 17 sites across 14 states. AR-V7 assay results were reported either as CTC negative (21/80: 26%), CTC+ AR-V7 negative (26/80: 33%), or CTC+ AR-V7 positive (33/80: 41%). Prevalence of AR-V7 detection increased with prior exposure to AR targeted drugs (Abi/Enza-naive 29%, post-Abi or Enza 39%, post-Abi and Enza 62%). Overall, management was impacted by AR-V7 testing in 54% of cases (43/80), and even more so with AR-V7+ results (see Table). AR-V7+ pts were commonly switched from AR targeted therapies to a taxane (10/19: 53%) or were offered a clinical trial (8/19: 42%). Pts who had a change in management based on AR-V7 testing were more likely to achieve a PSA 50 response on next-line therapy than those not changing treatment (18/36: 50% vs 10/30: 33%). Conclusions: Providers used AR-V7 testing to influence clinical practice more often than not. AR-V7+ pts were most often treated with taxane-based therapy or offered a clinical trial, which may have improved outcomes. Clinical qualification of AR-V7 is ongoing. [Table: see text]
Abstract 18791: Immune Cell Derived Nerve Growth Factor Initiates Neurogenic Hypertension in Obesity
Authors: Grant R Drummond, Klaus I Matthai, Susan K Morton, Antony Vinh, Dorota M Ferens, Juila I Ellyard, Carola G Vinuesa, Caryl E Hill, Rebecca E Haddock
Journal: Circulation (2015)

Introduction: Hypertension in the obese is a rapidly increasing problem. It has both neurological and immunological antecedents, however the relationship between these is unclear. Methods and Results: Here we used a mouse model of diet-induced obesity, pressure myography, immunohistochemistry, flow cytometry and radiotelemtry to demonstrate that immune cells, located within the vascular adventitia of arteries important for controlling blood pressure, produce nerve growth factor (NGF) and rapidly initiate growth of the perivascular sympathetic nerve plexus; which increases vascular tone and thereby elevates blood pressure. We also show that Rag1-/- mice lacking T and B cells do not develop hypertension when obesity is induced with a high fat diet (HFD) and show that their sympathetic innervation and vascular tone remains normal, suggesting that neurogenic hypertension in the obese likely occurs independently of weight gain. Furthermore, we show that the adoptive transfer of wildtype CD3+ T cells restores the sympathetic hyperinnervation and associated hypertension whereas the transfer of CD3+ T cells deficient in NGF had no effect on sympathetic innervation or blood pressure. Conclusion: These results not only demonstrate the role of T cells in the genesis of obesity-related hypertension but also demonstrate the pivotal role of NGF in linking dysfunction of the immune and sympathetic nervous systems that characterize hypertension in the obese. a, Change in body weight b, nerve-mediated contraction amplitude recorded from pressurized small mesenteric arteries (1Hz, 30s) and c, systolic BP in mice in RAG-1-/- mice, which lack B and T cells, fed NCD or HFD. RAG-1-/-Tcell mice are recipients of CD3+ T cells via adoptive transfer. d, Perivascular nerve density (synaptophysin) over wholemount small mesenteric arteries from RAG-1-/- mice. Scale, 50μm.
Breast mass in a 69-year-old woman
Authors: G. Hermann
Journal: JAMA (1986)

A 69-year-old woman was initially seen with a mass in the right breast of four days' duration. <h3>Clinical History</h3> A 69-year-old woman was initially seen with constant abdominal pain in the epigastrium and right upper quadrant, with nausea and vomiting of three days' duration. On examination, moderate tenderness and guarding in the right upper quadrant of the abdomen were noted. A leukocytosis of 11,000/cu mm, with a mild shift to the left, was present. Findings from a sonogram and hepatobiliary scan were consistent with a diagnosis of acute cholecystitis for which intravenous (IV) antibiotic therapy was instituted. Results of radiological studies performed on the second hospital day showed a small-bowel obstruction. On surgical exploration, a gangrenous segment of the terminal ileum was resected and an end-to-end anastomosis was performed. The resected bowel demonstrated hemorrhagic infarction with evidence of focal organizing venous thrombosis in the mesentery. The patient was initially started
Update: A 54-Year-Old Woman With Constipation-Predominant Irritable Bowel Syndrome
Authors: Nadine Farag, Eileen Reynolds, Anthony Lembo
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal