Primary Hyperoxaluria
Authors: ANGUS W. MCLAURIN
Journal: Annals of Internal Medicine (1961)

Article1 July 1961Primary HyperoxaluriaANGUS W. MCLAURIN, WILLIAM R. BEISEL, GERALD J. MCCORMICK, M.S., RAYMOND SCALETTAR, ROBERT H. HERMANANGUS W. MCLAURIN, WILLIAM R. BEISEL, GERALD J. MCCORMICK, M.S., RAYMOND SCALETTAR, ROBERT H. HERMANAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-70 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrimary hyperoxaluria is characterized by an increased urinary excretion of oxalate and the deposition of calcium oxalate crystals in the kidneys and other organs. This metabolic defect was thought initially to be a severe disease of infancy and childhood, characterized by recurrent nephrolithiasis and pyelonephritis and by a progressive course terminating in a uremic death. Studies by Newns and Black (1) in 1953 and by Aponte and Fetter (2) in 1954 demonstrated an increased urinary excretion of oxalate prior to death in such patients. 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