tbuckley/cabot-search huggingface dataset:
SANITARIA FOR THE CONSUMPTIVE POOR.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Levothyroxine Therapy
Authors: Matthew C. Leinung
Journal: Annals of Internal Medicine (1994)

Letters1 April 1994Levothyroxine TherapyMatthew C. Leinung, MDMatthew C. Leinung, MDAlbany MEdical College; Albany, NY 12208Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-7-199404010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I take exception to the outdated recommendation in the otherwise excellent review of thyroid hormone use [1] for using levothyroxine to temporarily suppress solitary, nonfunctioning, benign nodules [2, 3]. The authors admit that randomized, controlled trials do not show any benefit of levothyroxine use over placebo in shrinking nodules. What, then, is being accomplished? Because thyroid cancers respond to levothyroxine therapy, those whose nodules shrink, still require observation and possible repeat biopsy [2]. Surgery is generally recommended if the nodule grows, whether or not the patient is receiving levothyroxine. If the size of the nodule remains unchanged, ...References1. Mandel, SJ, Brent GA, Larsen PR. Levothyroxine therapy in patients with thyroid disease. Ann Intern Med. 1993; 119:492-502. Google Scholar2. Gharib H, Goellner JR. Fine-needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med. 1992; 118:282-9. Google Scholar3. Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med. 1993; 328:553-9. Google Scholar4. Featherstone HJ, Stewart DK. Angina in thyrotoxicosis: thyroid related coronary artery spasm. Arch Intern Med. 1983; 143:554-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Matthew C. Leinung, MDAffiliations: Albany MEdical College; Albany, NY 12208 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1994Volume 120, Issue 7Page: 619-620KeywordsBiopsyForecastingSurgeryThyroidThyroid carcinomaThyroid hormonesThyroidectomyThyroxine ePublished: 15 August 2000 Issue Published: 1 April 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Thirteenth Annual Report of the Craig Colony for Epileptics at Sonyea, N. Y. Adopted by the managers, Oct. 9, 1906.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2017)

Publicly available data sets, such as the National Inpatient Sample (NIS), are often used for research on patterns and outcomes of health care.In a review of a representative sample of 120 recent published studies using data from the NIS, Khera and colleagues found that most lacked essential research elements. Clinical Review & Education Hidradenitis Suppurativa 2019Hidradenitis suppurativa is an infl ammatory skin disorder with recurrent, painful, suppurating lesions found predominantly in intertriginous areas.Saunte and Jemec review the clinical treatment of patients with this disabling and stigmatizing disease. CME jamanetwork.com/learning Wrong-Site Surgery 2033This article in the JAMA Performance Improvement series explores the case of a patient with two breast masses, one malignant and one benign.The benign mass was excised by mistake.Engelhardt and colleagues discuss the clinical management of wrong-site surgery.
Prognostic Gene Expression Signature for Squamous Cell Carcinoma of Lung
Authors: Chang-Qi Zhu, Dan Strumpf, Chun-Yan Li, Qing Li, Ni Liu, Sandy Der, Frances A. Shepherd, Ming-Sound Tsao, Igor Jurisica
Journal: Clinical Cancer Research (2010)

This study aimed to identify and validate a gene expression signature for squamous cell carcinoma of the lung (SQCC).A published microarray dataset from 129 SQCC patients was used as a training set to identify the minimal gene set prognostic signature. This was selected using the MAximizing R Square Algorithm (MARSA), a novel heuristic signature optimization procedure based on goodness-of-fit (R square). The signature was tested internally by leave-one-out-cross-validation (LOOCV), and then externally in three independent public lung cancer microarray datasets: two datasets of non-small cell lung cancer (NSCLC) and one of adenocarcinoma (ADC) only. Quantitative-PCR (qPCR) was used to validate the signature in a fourth independent SQCC cohort.A 12-gene signature that passed the internal LOOCV validation was identified. The signature was independently prognostic for SQCC in two NSCLC datasets (total n = 223) but not in ADC. The lack of prognostic significance in ADC was confirmed in the Director's Challenge ADC dataset (n = 442). The prognostic significance of the signature was validated further by qPCR in another independent cohort containing 62 SQCC samples (hazard ratio, 3.76; 95% confidence interval, 1.10-12.87; P = 0.035).We identified a novel 12-gene prognostic signature specific for SQCC and showed the effectiveness of MARSA to identify prognostic gene expression signatures.
Gender disparity in the association of interleukin-10 and interleukin-12 polymorphisms with the progression of hepatitis B virus infection in Caucasians
Authors: Janett Fischer, Long Shuang, Koukoulioti Eleni, Tobias Müller, Fueloep Balazs, Heyne Renate, Thomas Berg, Florian van Bömmel
Journal: Journal of Hepatology (2020)
RATIONAL SANITATION.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Technology, Ethics
Authors: Stanley Joel Reiser
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Functional activin-HNF4A-coagulation axis in liver progenitor cells determines MELD score and outcome of acute-on-chronic liver failure
Authors: Tao Lin, Shanshan Wang, Rilu Feng, Xiaodong Yuan, Hui Liu, Chen Shao, Wandrer Franziska, Alexander Marx, Matthias Ebert, Heike Bantel, Steven Dooley, Huiguo Ding, Honglei Weng
Journal: Journal of Hepatology (2020)
IN A SINGLE CAPSULE
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cholera Associated With Food Transported From El Salvador—Indiana, 1994
Journal: JAMA (1995)

Since the onset of the cholera epidemic in Latin America in 1991, most cases of cholera in the United States have occurred among persons traveling to the United States from cholera-affected areas or who have eaten contaminated food brought or imported from these areas. In December 1994, a cluster of cholera cases occurred among persons in Indiana who had shared a meal of contaminated food brought from El Salvador. This report summarizes the investigation of the cases conducted by the Indiana State Department of Health (ISDH) in collaboration with the local health departments in Jasper and Newton counties (Indiana), the Illinois Department of Public Health, and the DeWitt-Piatt (Illinois) Bi-County Health Department.
Veterinary center safeguards larger public
Authors: T. Ziporyn
Journal: JAMA (1985)

"The M. he Center for Veterinary Medicine is really a microcosm of the Food and Drug Administration—for animals," says Gerald B. Guest, DVM, deputy director of the center. In other words, he explains, while there's a center each for human drugs, human devices, and human foods, this one center regulates all three for animals. Still, Guest says, "our first concern is public health, then animal welfare." Established in 1965, this center has five basic functions: To develop and recommend the veterinary medical policy of the FDA for the safety and efficacy of animal drugs, feed additives, and devices (including international activities and liaisons). To evaluate, for animal safety and efficacy, proposed and marketed animal drugs, feed additives, and devices. To coordinate the veterinary medical aspects of agency inspectional and investigational programs and to provide veterinary medical opinions in animal drug hearings and court cases. To plan,
227P Cardiotoxicity in HER2 positive breast cancer patients treated with trastuzumab
Authors: M. Lopez, C. Minguito Carazo, I. Delgado Sillero, M. Rojas Piedra, B. Távara Silva, A. López-González, C. Castañón López, B. Nieto Mangudo, M. Pedraza Lorenzo, Á. Rodríguez Sánchez, P. Diz Taín, L.M. De Sande González, S. Medina Valdivieso, L. López González, E. Honrado Franco, A. García-Palomo, L.F. Sánchez-Cousido
Journal: Annals of Oncology (2020)
Diabetes: Directions for Treatment by Insulin and Diet.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
U.S. Cancer Organizations Campaign to Bolster Support of Cancer Research
Journal: JNCI Journal of the National Cancer Institute (1995)

U.S. Cancer Organizations Campaign to Bolster Support of Cancer Research Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 5, 1 March 1995, Pages 344–345, https://doi.org/10.1093/jnci/87.5.344 Published: 01 March 1995
Analyzing Computer-based Decision Support Systems
Authors: R. Brian Haynes
Journal: Annals of Internal Medicine (1994)

Letters15 September 1994Analyzing Computer-based Decision Support SystemsR. Brian HaynesR. Brian HaynesMcMaster University, London, Ontario, Canada L8N 375Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-6-199409150-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:McDonald and colleagues raise important points. First, the weight we gave to the unit of randomization was based on concerns about contamination. This was judged to be especially important in evaluating computerized decision support systems, particularly early in their development, and the effects to date have been small. Thus, we did not wish to bias our review against such systems by considering those that had been tested with randomization within groups to be on the same footing as those with randomization in separate, independent groups. It is true, however, that, in a given circumstance, the most appropriate approach ... Author, Article, and Disclosure InformationAffiliations: McMaster University, London, Ontario, Canada L8N 375 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1994Volume 121, Issue 6Page: 469KeywordsClinical decision support systemsComputersComputing systemsSystematic reviews Issue Published: 15 September 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Student loans: deferment and forbearance provisions
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Validation of a Novel Multiplex Kit for All RAS Mutations in Colorectal Cancer: Results of Rasket (Ras Key Testing) Prospective Multicenter Study
Authors: Kudo Toshihiro, Satoh Taroh, Muro Kei, Taniguchi Hiroya, Yamaguchi Kensei, Akagi Kiwamu, Nishina Tomohiro, Kajiwara Takeshi, Denda Tadamichi, Hironaka Shuichi, Okamoto Wataru, Yoshino Takayuki
Journal: Annals of Oncology (2014)
Fragmentation, coherence, and the perception/action divide
Authors: Erik Myin
Journal: Behavioral and Brain Sciences (2001)

I discuss Stoffregen &amp; Bardy's theory from the perspective of the complementary aspect of input conflict, namely, imput coherence - the unity of perception. In a classical approach this leads to the famous “binding problem.” The conceptual framework the authors construct leaves no space for a binding problem to arise. A remaining problem of perceptual conflict, arising in cases of inversion of the visual field can be handled by the theory the authors propose.
THE LOSS OF PANCREATIC JUICE
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular Evidence of Lentiviral Vector-Mediated Gene Transfer into Human Self-Renewing, Multi-potent, Long-Term NOD/SCID Repopulating Hematopoietic Cells
Authors: L AILLES, M SCHMIDT, F SANTONIDESIO, H GLIMM, S CAVALIERI, S BRUNO, W PIACIBELLO, C VONKALLE, L NALDINI
Journal: Molecular Therapy (2002)

A major challenge in gene therapy is to achieve efficient transduction of hematopoietic stem cells (HSC). It has previously been shown that lentiviral vectors (LV) transduce efficiently human cord blood-derived NOD/SCID mouse repopulating cells (SRC). Here we studied the effect of cytokines during the short ex vivo incubation with vector. Although SRC transduction was efficient without stimulation, the presence of cytokines significantly improved it. The treatment did not affect the engraftment level or the SRC frequency, but seemed to enhance SRC susceptibility to LV. SRC transduced in both conditions repopulated primary and secondary recipients, maintaining stable multi-lineage transgene expression. Using linear amplification-mediated PCR, we then analyzed vector integration in the bone marrow and CFC of the engrafted mice to monitor the clonal activity of the transduced SRC in vivo. We showed polyclonal engraftment, multi-lineage differentiation, and propagation to secondary recipients of individual SRC. We observed multiple integrations in most clones. These results provide the first formal demonstration that primitive human HSC with self-renewal and multi-lineage repopulation capacities were transduced by LV. Our findings are relevant for the design of clinical protocols that exploit this system to reach significant engraftment by genetically modified HSC in the absence of in vivo selection or strong conditioning regimens.
Occurrence of by-products of strong oxidants reacting with drinking water contaminants--scope of the problem.
Authors: R G Rice, M Gomez-Taylor
Journal: Environmental Health Perspectives (1986)

This paper describes results of a detailed literature review of the organic and inorganic by-products that have been identified as being formed in aqueous solution with four of the strong oxidizing/disinfecting agents commonly employed in drinking water treatment. These agents are: chlorine, chlorine dioxide, chloramine, and ozone. Significant findings include the production of similar nonchlorinated organic oxidation products from chlorine, chlorine dioxide, and ozone. In addition, all three chlorinous oxidants/disinfectants can produce chlorinated by-products under certain conditions. The presence of chloronitrile compounds in drinking waters is indicated to arise from reactions of chlorine or chloramine to amine/amide functions in amino acids or proteinaceous materials, followed by dehydrohalogenation. These nitriles could hydrolyze to produce the corresponding chloroacetic acids. It is concluded that to minimize the presence of oxidation by-products in drinking waters, the concentrations of oxidizable organic/inorganic impurities should be lowered before any oxidizing agent is added.