tbuckley/cabot-search huggingface dataset:
Lumbar Puncture
Authors: Eben Alexander
Journal: JAMA (1967)

The technique of lumbar puncture was described by Quincke more than 75 years ago.<sup>1(p309-312)</sup>This method, therefore, has been available to the practitioner of medicine for three quarters of a century and has achieved increasing importance in medical diagnosis and treatment. Originally, lumbar puncture was conceived as a means of treating hydrocephalus and for the detection of tuberculosis of the central nervous system. The brilliance of the discovery by Quincke is obvious. A translation of the description of his technique, and a subsequent description of the dynamics of the cerebrospinal fluid by Queckenstedt, some 30 years later,<sup>1(p301-308)</sup>have become available recently in Wilkins'<i>Neurosurgical Classics</i>for English-speaking physicians. Quincke could have had little concept of the increasing value of his discovery in 1882, since many of the uses to which the technique have been put have necessarily awaited other broad discoveries and the development of new concepts of
Fetal Pain
Authors: Bobbi J Lyman
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROTECTION AGAINST IRRADIATION
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE FROUDE-CARLYLE CONTROVERSY.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How and Why Genetic Linkage Has Not Solved the Problem of Psychosis: Review and Hypothesis
Authors: Timothy Crow
Journal: American Journal of Psychiatry (2007)

Objective: The author examined the chromosomal linkage method as an approach to the genetic basis of schizophrenia and bipolar disorder. Method: Comparisons were conducted of recent meta-analyses of genome scans of schizophrenia and bipolar disorder and of the three largest (N>300) sibling pair studies of schizophrenia and schizoaffective disorder and a comparable study of bipolar illness. Results: Recent meta-analyses have not identified consistent sites of linkage. The three largest studies of schizophrenia fail to agree on a single locus, no commonality with bipolar illness has been demonstrated, and there is no replicable support for any of the current candidate genes. Discussion: An alternative to the concept that DNA sequence variation lies in "multiple genes of small effect" is the hypothesis that the variation is epigenetic but related to the genetic transition ("the speciation event") that separated Homo sapiens from a prior hominid species. This hypothesis draws attention to the chromosomal rearrangement (the Xq21.3/Yp translocation) that occurred some 6 million years ago in the hominid lineage and subsequent rearrangements, including a paracentric inversion, that have taken place within the translocated segment. Here it is argued that the most recent of these events is relevant to specifically human characteristics, including language. The gene pair protocadherin X and Y within this region is under new selective pressure and is in a novel (epigenetic) situation with respect to X inactivation. Conclusions: Epigenetic variation associated with chromosomal rearrangements that occurred in the hominid lineage and that relates to the evolution of language could account for predisposition to schizophrenia and schizoaffective and bipolar disorder and failure to detect such variation by standard linkage approaches.
David Rall: screening for future surprises
Authors: W. Check
Journal: JAMA (1979)

Congressional legislation calling for comprehensive toxicity testing of chemicals and the almost simultaneous formation of the National Toxicology Program (NTP) last November signal the heightening interest in the screening of chemicals to prevent public health problems. The NTP will coordinate activities in toxicology by four government agencies—the National Institute of Environmental Health Science (NIEHS), the National Cancer Institute (NCI), the Food and Drug Administration (FDA), and the National Institute of Occupational Safety and Health (NIOSH). At the center is David Rall, MD, PhD, director of NIEHS, who has been chosen to head the NTP while remaining in his NIEHS post. With a background in pharmacology, Rall, now 52, spent some early years at the NCI where he became interested in testing for toxic effects of anticancer drugs. He was associate director of the institute for a time and then, in 1971, was tapped to be director of the NIEHS. As
Journal National Cancer Institute, Washington
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Robert Blowers
Journal: BMJ (2005)

Medical microbiologist who became a pioneer of hospital infection controlRobert Blowers had a lifelong interest in Staphylococcus aureus and hospital infection.From the mid-1950s onwards he produced a succession of publications on the prevention of hospital infections, particularly those following surgery.These ranged across the design of operating theatres, isolation rooms, and surgical clothing, and the prevention of the airborne spread of infection and clinical protocols for wound management.He co-produced the seminal textbook Hospital Infection: Causes and Prevention, which became the "bible" on infection control for nearly 20 years.In 1959 he was a key member of the Ministry of Health working group that produced a report on staphylococcal infections in hospitals.At a Department of Health workshop in December 2004, just a week before Robert's death, his major contribution was recalled by the department's inspector of microbiology and infection control, who had that week sent him a Christmas card with the message "you will be pleased to know that we are at last trying to implement your 1959 recommendations!"
Hypnotic Drugs
Authors: Louis Lasagna
Journal: New England Journal of Medicine (1972)

SLEEP disturbance is a common problem. Insomnia ("hyposomnia" would be more precise) is, in the style of Lewis Carroll's Humpty Dumpty, "just what I choose it to mean – neither more nor less" (i.e., if a patient believes himself to be getting too little sleep, or sleeping too lightly, and feels "tired" the next morning because of this, he suffers from insomnia). The physician may have a different standard – he may sleep two hours less a night than the patient and consider the patient fortunate! – and, of course, may choose to manage patients depending on his assessment of . . .
In Reply
Authors: Daniël C. Aronson
Journal: Journal of Clinical Oncology (2007)

Meyers et al criticize the methodology with which the value of the Pretreatment Extent of Disease (PRETEXT) system has been evaluated, and question the validity of the comparison between PRETEXT and the Children's Cancer Study Group/Pediatric Oncol-ogy Group (CCSG/POG) staging.Because we compared PRETEXT with a gold standard (which is essential for a good epidemiologic study), 1 the study had to be limited to the comparison of the preoperative PRETEXT with the (postoperative) resection specimen.This
Urate Binding
Authors: PETER J. RAVENSCROFT
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 July 1973Urate BindingPETER J. RAVENSCROFT, M.B.PETER J. RAVENSCROFT, M.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-1-140_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Klinenberg suggests in the January UCLA Conference (Ann Intern Med78:99-111, 1973) that abnormalities in urate binding may be significant in the pathogenesis of urate deposition disease. The rationale for this statement appeared to be supported by in vitro binding studies performed at 4°C. In the original report of this in vitro binding method (1) the effect of temperature on urate binding at 37°C suggests that the binding of urate in vivo is likely to be insignificant, and this conclusion has recently been supported by Farrell, Popovich, and Babb (2), who studied pure uric acid rather...References1. KLINENBERG J and KIPPEN I: The binding of urate to plasma proteins by means of equilibrium dialysis. J Lab Clin Med 75:503-509, 1970 MedlineGoogle Scholar2. FARRELL P, POPOVICH R, and BABB A: Binding levels of urate ions in human serum albumin and plasma. Biochim Biophys Acta 243:49-52, 1971 CrossrefMedlineGoogle Scholar1. BLATT W, ROBINSON S, and BIXLER H: Membrane ultrafiltration. The diafiltration technique and its application to microsolute exchange and binding phenomena. Ann Biochem 26: 151-173, 1968 CrossrefGoogle Scholar2. WHITEHOUSE M: Increasing excretion of urate with displacing agents in man. January 1973 conference on drug protein binding. Ann NY Acad Sci. In press CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PETER J. RAVENSCROFT, M.B.Affiliations: Department of Medicine University of Queensland Brisbane Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMonoterpenoids 1 July 1973Volume 79, Issue 1Page: 140-141KeywordsPathogenesisTemperatureUric acid ePublished: 1 December 2008 Issue Published: 1 July 1973 PDF downloadLoading ...
Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility
Authors: Martin Valdearcos, John D. Douglass, Megan M. Robblee, Mauricio D. Dorfman, Daniel R. Stifler, Mariko L. Bennett, Irene Gerritse, Rachael Fasnacht, Ben A. Barres, Joshua P. Thaler, Suneil K. Koliwad
Journal: Cell Metabolism (2018)
The Common Fate of Epochal Works
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Colds with a Capsule Form of the Herb Echinacea
Journal: Annals of Internal Medicine (2002)

Summaries for Patients17 December 2002Treatment of Colds with a Capsule Form of the Herb EchinaceaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-12-200212170-00001 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?The common cold is one of the most frequent human illnesses. Many different viruses cause colds. No “cure” for the common cold exists, but people use a variety of treatments to try to decrease the bothersome symptoms of colds. Echinacea is an herb that some claim is helpful in treating colds. However, it is uncertain whether echinacea is truly beneficial in treating colds.Why did the researchers do this particular study?To find out whether people who begin taking echinacea soon after cold symptoms start have symptoms that ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Treatment of the Common Cold with Unrefined Echinacea. A Randomized, Double-Blind, Placebo-Controlled Trial.” It is in the 17 December 2002 issue of Annals of Internal Medicine (volume 137, pages 939-946). The authors are BP Barrett, RL Brown, K Locken, R Maberry, JA Bobula, and D D'Alessio.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTreatment of the Common Cold with Unrefined Echinacea Bruce P. Barrett , Roger L. Brown , Kristin Locken , Rob Maberry , James A. Bobula , and Donn D'Alessio Metrics 17 December 2002Volume 137, Issue 12Page: I-18KeywordsAntibioticsAntihistaminesAsthmaCommon coldPharyngitisPregnancyQuestionnairesYoung adults ePublished: 17 December 2002 Issue Published: 17 December 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
LEPROSY IN WISCONSIN.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: side effects of practolol.
Journal: BMJ (1975)

Side Effects of PractololDoctors have received three letters in recent months, one from the Committee on Safety of Medicines and two from Imperial Chemical Industries, on the side effects of practolol (Eraldin).The principal adverse drug reactions associated with practolol affect the skin, eyes, oral and nasal mucous membranes, ears, and peritoneum.These changes are associated with immuno- logical disturbances affecting epidermal tissue and may pro- duce L.E. cell phenomena.Nevertheless, the adverse effects should be kept in perspective as practolol has been widely used since 1970 (more than 200 000 patient years) in the treatment ofischaemic and obstructive heart disease, atrial dysrhythmias, mild to moderate hypertension, and thyrotoxicosis.Early reports1 confirmed the efficacy and selectivity of practolol given intravenously (1200 patients) and orally (900 patients).A total of 223 patients were studied for periods of 6-24 months (average 10 months) while taking oral doses of 100-4000 mg daily (average 800 mg).Side effects were un- common, but heart failure, bradycardia, hypotension, and bronchospasm were all recorded.Constipation appeared to be dose-dependent, while gastric upset, nausea, vomiting, fatigue, depression, and vivid dreams were reported in only a few patients.Seven patients developed rashes of varied types, and this was confirmed by Zacharias2 in 19 out of 156 hypertensive patients on practolol.The report of practolol-induced exfoliative dermatitis3 alerted clinicians to the hazards of therapy using this drug.Since then a wide variety of skin lesions, independent of age, sex, or length of exposure to practolol, have been described.Psoriasiform, eczematous, seborrhoeiform, lichenoid, and mixed rashes have been observed.4Most patients improve on withdrawal of the drug or the application of topical steroids in more severe cases.
Degenerative Lumbosacral Transitional Articulation
Authors: GÖKHAN PEKINDIL, YESIM PEKINDIL, ALI SARIKAYA
Journal: Clinical Nuclear Medicine (2002)

From the Departments of Radiology,* Physical Therapy and Rehabilitation,† and Nuclear Medicine, ‡ Trakya University Medical Faculty, Edirne, Turkey Received for publication January 7, 2002. Revision accepted March 25, 2002. Correspondence: Gökham Pekindil, Department of Radiology, Trakya University Medical Faculty, Edirne, Turkey.
Involuntary Sterilization
Authors: Edgar B. Keemer
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Recent reports from Montgomery, Ala, of 11 teen-age girls having been "involuntarily" sterilized in a federally funded birth-control clinic should serve to awaken us to the need for closer monitoring of such facilities. There is also another aspect of this problem that is becoming quite commonplace: In many parts of the country, tubal ligations are being performed casually, concomitant with legal abortions both in hospitals and in independent clinics. Abortion proponents must realize that sterilization under overt or covert pressure is just as much of an affront to free women as was forced pregnancy. The illiterate black mother of the 12- and 14-year-old girls who thought she was authorizing the birth control shot apparently had the release form for sterilization shoved in front of her for the affixing of her "X." In a similar vein, there may be other young women frantic to escape from the tightening