tbuckley/cabot-search huggingface dataset:
Acta: Unio Int Contra Cancrum, Louvain
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elektrotherapie. Ein Lehrbuch.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of sunitinib (su) versus temsirolimus (tem) in patients (pts) with poor risk metastatic renal cell carcinoma (prmRCC).
Authors: Victoria Neiman, Daniel Keizman, Avishay Sella, Eli Rosenbaum, Maya Gottfried, Natalie Maimon, David Sarid, Eli Gez, Michael Anthony Carducci, Hans J. Hammers, Mario A. Eisenberger, Victoria J. Sinibaldi, Avivit Peer, Avivit Neumann, Svetlana Kovel, Wilmosh Mermershtain, Keren Rouvinov, Ilan Feldhamer, Raanan Berger, Ariel Hammerman
Journal: Journal of Clinical Oncology (2016)

e16090 Background: Based on a single phase 3 study, the mTOR inhibitor tem was approved as 1st line therapy for prmRCC. However, in daily practice, prmRCC pts are often treated with the VEGFR and PDGFR inhibitor su. We aimed to compare the clinical effectiveness of su vs tem in prmRCC pts. Methods: We performed an international multicenter retrospective study of pts with prmRCC (HENG criteria), who were treated in 8 centers across 2 different countries. 31 pts were treated with 1st line tem. Each tem treated pt was individually matched with a 1st line su treated pt, by clinicopathologic factors. The effect of tx type (tem vs su) on clinical benefit, progression free survival (PFS) and overall survival (OS), was tested using a chisquare test and partial likelihood test from cox model. Furthermore, univariate and multivariate analyses of association between clinicopathologic factors and tx type (tem vs su), and outcome were performed using the entire pt cohort (n = 62). Results: The groups were matched by age (median 65), gender (male 68%), prior nephrectomy (58%), renal cell carcinoma histology (clear cell 81%), smoking status (active in 35%), use of angiotensin system inhibitors (42%), and pre-tx neutrophil to lymphocyte ratio > 3 (58%). In tem vs su treated pts, clinical benefit (partial response + stable disease) was 61% (n = 19) (partial response 6%, n = 2) vs 71% (n = 22) (partial response 29%, n = 9) (p = 0.62). Median PFS was 5 vs 8 mos (p = 0.08), and median OS 9 vs 17 mos (p = 0.03). In multivariate analyses of the entire pt cohort (n = 62), su tx was independently associated with OS (HR 0.6, p = 0.001). Conclusions: In prmRCC patient, the VEGFR inhibitor su may be associated with an improved outcome vs the mTOR inhibitor tem.
Management of heel pain
Journal: JAMA (1978)

<h3>To the Editor.—</h3> I read the remarks by Dr Giannestras in QUESTIONS AND ANSWERS. My interest in the topic of heel pain stems from my longstanding association with the Diabetic Foot Clinic at Georgetown University Hospital and through my position as clinical instructor of surgery in the Department of Orthopedics at Georgetown University Medical School. Dr Giannestras states that the heel pain in question is "probably circulatory in origin" because the pain is present when the patient awakens in the morning and disappears as soon as ambulation is begun. He further states that since the patient is mildly diabetic, there is probably some degree of peripheral vascular disease present. Further along it is suggested that the patient try applying a heat pad to the foot as a form of therapy for relief of the symptoms. It has been my experience that heel pain that is present on arising in the
Milestones
Authors: Ibiayi Dagogo-Jack
Journal: Annals of Internal Medicine (2014)

Ad Libitum19 August 2014MilestonesIbiayi Dagogo-Jack, MDIbiayi Dagogo-Jack, MDFrom Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-1379 Audio Reading - “Milestones” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Milestones," by I. Dagogo-Jack. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I wonder about calendarsWhether life is better spent counting days or counting moons,Counting trays or afternoons;Whether it is best to trackSide to side or front to back,Blocks walked or miles flownWhen tallying up our milestones.She spends her morning chasing countsIt helps her get a better sense, of whether cancer's come or gonePlotting life on lines we'e drawn.She wonders if it's left to fateIf hair will grow and bones will ache.If applause within her long bonesIs a chance at life or cancer's own?Neglecting ... Author, Article, and Disclosure InformationAffiliations: From Boston, Massachusetts.Current Author Address: Ibiayi Dagogo-Jack, MD; e-mail, ibiayi.[email protected]com PreviousarticleNextarticle Advertisement Audio Reading - “Milestones” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Milestones," by I. Dagogo-Jack. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 19 August 2014Volume 161, Issue 4Page: 269KeywordsBonePain ePublished: 19 August 2014 Issue Published: 19 August 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hodgkin's disease exclusively with bone marrow involvement
Authors: D. Willerson
Journal: JAMA (1970)

<h3>To the Editor.—</h3> During the course of illness lymph node involvement may be detected in almost all patients with Hodgkin's disease.<sup>1</sup>Involvement of other organs such as spleen and liver is also common.<sup>2</sup>This report describes a patient who presented with pancytopenia. Reed-Sternberg cells were found in two bone marrow aspirations before starting chemotherapy and on bone marrow sections taken at autopsy. Neither clinical nor postmortem involvement of lymph nodes or other organs was detected. <h3>Report of a Case.—</h3> A 70-year-old man admitted to the hospital because of pancytopenia had noted only increasing fatigue and dyspnea on exertion during the previous five months. His medications included sulfinpyrazone (Anturane) and diazepam (Valium). Abnormal physical findings included pallor, petechiae over both lower extremities, and flame-shaped hemorrhages in the left fundus. There was no sternal tenderness, hepatosplenomegaly, or lymphadenopathy. Hemoglobin level was 9.8 gm/100 ml, reticulocyte count was 0.9%, mean corpuscular
Dissection of the aorta.
Journal: BMJ (1979)

for total parenteral feeding of infants of low birth weight unless the unit is carrying out a research study.The American Academy of Paediatrics gave similar advice about seven years ago'3 and reported it,'4 and many will find it surprising that paediatricians continue to use this costly, dangerous form of treatment indiscriminately.What should we do now?Depending on the medical and nursing staff available, each unit will have to decide whether to use the transpyloric route rather than the gastric route.Weary neonatal house physicians may not display the same enthusiasm for conquering the obstinacy of the pylorus as the research registrar: with any luck a better tube may soon become available.
Tracheobronchomegaly
Authors: Z. Al-Mallah, O. P. Quantock
Journal: Thorax (1968)

Two cases of the rare condition of tracheobronchomegaly are reported. They occurred in people of completely different racial origin and residence. They showed the characteristic features of this condition—loud, rasping, prolonged, remarkably ineffective cough, abnormally wide trachea and major bronchi, laxity of the cartilaginous rings and membranous part of these airways demonstrable on straight chest radiographs and bronchoscopy and confirmed at bronchography. Evidence is submitted of congenital aetiology.
Expectorant promising for treating infant respiratory distress syndrome
Authors: J. Henahan
Journal: JAMA (1983)

A drug originally developed as an expectorant for various respiratory conditions appears to reduce the incidence and mortality rate of respiratory distress syndrome (RDS) in preterm infants when administered antenatally to the mothers. It has been estimated that about 30,000 preterm infants die yearly in the United States from the effects of RDS. Called ambroxol, the agent also appears to hasten recovery from RDS when administered to affected infants soon after birth. Preliminary clinical findings indicate that the drug does not have the adverse effects of corticosteroids that currently are given antenatally to hasten lung maturation and avert RDS in infants expected to be born before term with immature lungs. Results with corticosteroids have been erratic, depending on the neonate's sex, race, and time of delivery, among other factors. By suppressing the immune system, the steroids leave both mother and infant highly susceptible to viral and bacterial infections. In addition,
THE GRAVES SYNDROME
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantifying the impact of achieving the World Health Organization global health sector strategy goals for hepatitis C in the African Region
Authors: S. Robbins, S. Blach, S. Brandon, C. Estes, I. Gamkrelidze, H. Nde, D. Razavi-Shearer-Spink, J. Schmelzer, H. Razavi
Journal: Journal of Hepatology (2018)
Editorial: Antibiotics in surgery.
Journal: BMJ (1975)

1975 3 search procedure).If gonadotrophins and testosterone are low, hypothalmic or pituitary disease is likely.If gonadotrophins are high and testosterone very low then androgen therapy is probably indicated, if only to prevent or treat osteoporosis.Until further research has been conducted the less extreme "normal biochemical abnormalities" of advancing testicular age should probably be left alone.
Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
Authors: P Meier
Journal: Hepatology (1997)

The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.
Abstract A59: Macrophages orchestrate early dissemination of HER2+ cancer cells
Authors: Nina Linde, Arthur Mortha, Nicole Saenger, Maria Sosa, Ethan Tardio, Tanja Fehm, Thomas Karn, Miriam Merad, Julio Aguirre-Ghiso
Journal: Cancer Research (2016)

Abstract Metastatic dissemination can already occur during early pre-invasive breast cancer stages. However mechanisms that control early cancer cell dissemination are unclear. Here we show that MMTV-HER2 early cancer lesions contain an invasive subpopulation of HER2+/E-cadherinlo cancer cells that disseminate by recruiting resident CD206+ mammary tissue resident macrophages (MTMs). This occurs months before monocyte-derived macrophages are recruited into advanced tumors. Early HER2+ lesions, but not healthy mammary tissue, produced CCL2 in an NFκB dependent manner and recruited intra-ductal MTMs, that secreted Wnt1 and thereby induced an epithelial to mesenchymal transition (EMT) in the early HER2+ cancer cells. Depletion of MTMs before overt tumors appeared prevented early cancer cells from undergoing an EMT and drastically reduced early dissemination. Surprisingly macrophage depleting therapy in MMTV-Her2 only during pre-malignant stages reduced alveolar metastases, even when mice went through invasive tumor stages and macrophages had repopulated the overt tumor tissue. Importantly, humans with DCIS lesions that contained macrophage+/E-Cadherinlo microenvironments frequently had disseminated cancer cell (DCCs) in the bone marrow. Taken together, we reveal that resident MTMs can promote early dissemination explaining how early cancer spread might proceed in breast cancer patients. We also propose that eDCCs play a long-term causal role in metastasis development. Citation Format: Nina Linde, Arthur Mortha, Nicole Saenger, Maria Sosa, Ethan Tardio, Tanja Fehm, Thomas Karn, Miriam Merad, Julio Aguirre-Ghiso. Macrophages orchestrate early dissemination of HER2+ cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr A59.
ADRENERGIC FACTORS AND BACTERIAL ENDOTOXINS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence and Progression of Subclinical Atherosclerosis in Younger Adults with Low 10-Year Risk but High Lifetime Risk for Cardiovascular Disease: Findings from the CARDIA and MESA Studies
Authors: Jarett D Berry
Journal: Circulation (2007)

Abstract 3482 Jarett D Berry, Kiang Liu, Northwestern University, Chicago, IL; Aaron R Folsom, University of Minnesota, Minneapolis, MN; Joseph F Polak, Tufts University, Boston, MA; Cora E Lewis, University of Alabama at Birmingham, Birmingham, AL; Steven Shea, Columbia University, New York City, NY; Stephen Sidney, Kaiser Permanente, Oakland, CA; J Jeffrey Carr, Wake Forest University, Winston-Salem, NC; Daniel H O’Leary, Tufts University, Boston, MA; Cheeling Chan, Donald M Lloyd-Jones, Northwestern University, Chicago, IL Jarett D Berry, 2007 Finalist and Presenting Author
CONTROL OF HUMAN HEREDITY
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Simultaneous determination of plasma mevalonate and 7alpha-hydroxy-4-cholesten-3-one levels in hyperlipoproteinemia: Convenient indices for estimating hepatic defects of cholesterol and bile acid syntheses and biliary cholesterol supersaturation
Authors: J Shoda
Journal: Hepatology (1997)

The high prevalence of cholesterol gallstone disease in hypertriglyceridemic patients may be associated with frequent metabolic defects in cholesterol and bile acid syntheses and in the concomitant formation of bile supersaturated with cholesterol. This study had the two aims: 1) to assess whether the defects as well as the degree of biliary cholesterol supersaturation in patients with hyperlipoproteinemia (HLP) can be estimated by the simultaneous determination of plasma mevalonate (MVL) and 7alpha-hydroxy-4-cholesten-3-one (C4); and 2) to assess the possible application of an estimated cholesterol saturation index ([CSI]E) as a means of evaluating the clinical effects of simvastatin on biliary lipid composition. Biliary cholesterol supersaturation was observed in patients with both IIa and IV HLP types. Consistent with the high activity and steady-state messenger RNA level of 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase, plasma MVL was significantly higher in 86 patients with HLP (38 type IIa, 44.1 +/- 2.4 nmol/L and 48 type IV, 56.7 +/- 2.3; P < .01) than in 41 normolipidemic subjects (34.2 +/- 1.5), closely correlating with the molar percentage of cholesterol in bile (r = .61, P = .0001; n = 86). On the other hand, consistent with the high activity and messenger RNA level of cholesterol 7alpha-hydroxylase, plasma C4 was significantly higher in patients with HLP (type IIa, 28.8 +/- 2.3 nmol/L and type IV, 38.3 +/- 2.7; P < .01) than in normolipidemic subjects (17.4 +/- 1.5). Plasma C4 was closely correlated with plasma MVL (r = .40, P = .0001; n = 86), but was inversely correlated with the molar percentage of bile acids in bile (r = .49, P = .0001; n = 86). Assuming that cholesterol supersaturation in patients with HLP may be governed by both an enhanced cholesterol secretion (closely reflected by plasma MVL) and a decreased secretion of bile acids (closely reflected by plasma C4), the multivariate linear regression-analyses revealed that an index defined as estimated CSI ([CSI]E) (%) in patients with HLP was given by the following equation using plasma MVL and C4 (nmol/L): [CSI]E = 1[MVL] + 0.7[C4] + 44.4. Biliary cholesterol supersaturation in patients treated with simvastatin improved in a manner parallel to the time course of decreases in plasma MVL and C4. The [CSI]E before and at the end of treatment were correlated with biliary CSI. These results indicate that defects of hepatic cholesterogenesis, and bile acid synthesis, and the degree of biliary cholesterol supersaturation in patients with HLP can be estimated exactly by the simultaneous determination of plasma MVL and C4; furthermore [CSI]E may be adopted for clinical use as a convenient index of biliary CSI. (Hepatology 1997 Jan;25(1):18-26)
Weather
Authors: Stephen Clark
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal