tbuckley/cabot-search huggingface dataset:
Hepatotoxicity after methoxyflurane administration
Authors: N. C. Klein
Journal: JAMA (1966)

METHOXYFLURANE (Penthrane) is a shortchain halogenated ether which was developed as a general anesthetic by Van Poznak and Artusio<sup>1</sup>and has been in clinical use since 1959. Although chemically an ether, this compound has organic chloride and fluoride substituents similar to that of halothane. In view of this structural similarity it might be expected that increasing use of methoxyflurane will be associated with rare reports of drug-induced hepatic injury. To our knowledge, this is the first nonfatal case of suspected methoxyflurane hepatotoxicity with documented hepatocellular necrosis. <h3>Report of a Case</h3> In June 1965, a 58-year-old Negro woman (NYH 159-803) was seen in the outpatient department complaining of a persistent vaginal discharge. A friable lesion, which on biopsy proved to be a squamous-cell carcinoma was noted in the vaginal vault. She was admitted for treatment in July 1965. She had suffered from attacks of acute pelvic inflammatory disease in 1939 and 1946 with episodic, recurrent lower abdominal pain. A hysterectomy and bilateral salpingo-oophorectomy was performed in 1953.
Tom Waller
Journal: BMJ (2004)

General practitioner who helped put harm reduction on the map of British drugs policy Tom Waller was a campaigning general practitioner who worked ceaselessly for a better deal for people with alcohol and drug problems.In his calm, determined, and persistent way he helped put harm reduction on the map of British drugs policy from the mid-1980s onwards.When harm reduction fell from the policy agenda in the late 1990s he vigorously worked to alert civil servants and ministers to the dangers of ignoring drug related harms, especially HIV and hepatitis C infection.He worked as a London general practitioner from 1973 to 1988, with a stint as GP trainer and tutor at London medical schools and then lecturer in general practice at University College Hospital/Middlesex Medical Schools.His initiation into problems of drug use came when he was the first medical adviser to the City Road crisis hostel for drug users in London (1978-83).The experience led to the first publication for GPs on treating drug users, Drug Addiction and Poly-drug Abuse: The Role of the GP.He joined the Ministerial Advisory Council on the Misuse of Drugs (ACMD) in 1983.He served on the ACMD working group whose 1988 report AIDS and Drug Misuse was the blueprint for the UK response to injecting related HIV infection.The insights in that document, including the view that "HIV is a greater threat to public health than drug misuse," helped support pragmatic public health oriented harm reduction interventions, including syringe exchange and methadone prescribing.These interventions subsequently kept the HIV rate among drug injectors in the United Kingdom at an extremely low level.
Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer (FOCUS)
Authors: M. T. Seymour, M. S. Braun, S. D. Richman, C. Daly, L. C. Thompson, A. Meade, M. Parmar, J. M. Allan, P. Selby, P. Quirke
Journal: Journal of Clinical Oncology (2006)

2022 Background: We present data on putative markers of chemotherapy toxicity from patients randomized to receive fluorouracil alone (FU), or FU+irinotecan (Ir), or FU+oxaliplatin (Ox). Methods: 1188 patients randomized to the FOCUS trial (ASCO 05 #3518) were analyzed. First-line therapy was FU in two thirds of patients, and FU+ either Ir or Ox in one third. Second-line Ir and Ox were administered to 29% and 14% of patients respectively. DNA was extracted from formalin-fixed, paraffin embedded (FFPE) blocks. Assessed DNA polymorphisms included TSER, TS1494, DPD IVS14 + 1G&gt;A, MTHFR C667T, MLH1 -93, UGT1A1*28, ABCB1 C3435T, GSTP1 105Val, XRCC1 Q399R and ERCC2 K751Q. The primary endpoint was chemotherapy delay or dose-reduction due to toxicity during the first 12 weeks of treatment. The secondary endpoint was incidence of CTC toxicity. The Chi-squared test was used to assess for associations. Results: In this exploratory analysis no molecular factors were observed to be associated with the primary endpoint (all p values &gt;0.1). Furthermore, no polymorphism predicted severe CTC toxicity in patients receiving FU alone (all p values &gt;0.1). XRCC1 variant allele carriers were at increased risk of severe CTC toxicity from Ir. Combined analysis of patients treated with first and second-line Ir appeared to show a significant association between toxicity and the presence of the variant XRCC1 allele across genotypes (57% versus 52% versus 38%; p=0.006). The UGT1A1*28 was not associated with Ir toxicity. No oxaliplatin markers predicted CTC toxicity. Conclusions: None of the assessed polymorphisms were significantly associated with the primary endpoint. Our results do not support the use of pharmacogenomics in routine clinical practice. In contrast to other studies the UGT1A1*28 VNTR was not associated with irinotecan toxicity . However, the XRCC1 Q399R polymorphism was associated with increased toxicity in patients receiving irinotecan, and these data may warrant further investigation, and independent confirmation. No significant financial relationships to disclose.
RISKS OF SUMMER RESORTS.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2018)

Posttraumatic stress disorder and other stress-related illnesses may aff ect immune function by disrupting the hypothalamic-pituitary-adrenal axis and autonomic nervous system.In a retrospective cohort study of 106 464 participants with stress-related disorders, 126 652 siblings, and 1 064 640 unaff ected participants selected randomly from the general population, Song and colleagues found that a diagnosis of stress-related disorder was associated with an increased risk of autoimmune disease. Inherited Mutations and Pancreatic Cancer 2401Cancer predisposition gene testing can identify individuals who may benefi t from screening, prevention, and early detection of disease.In a case-control study of 3030 adults diagnosed as having pancreatic cancer and 176 241 controls, Hu and colleagues identifi ed mutations in 6 genes associated with pancreatic cancer.An Editorial by Syngal and Furniss suggests that genetic screening at the time of diagnosis could have therapeutic implications for pancreatic cancer patients and their families.
<i>Erratum</i>: Vol. 68, No. 32
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

In the report "Healthy Contact Lens Behaviors Communicated by Eye Care Providers and Recalled by Patients -United States, 2018," on page 695, the first sentence of the third paragraph should have read "The majority of contact lens-wearing patients surveyed reported wearing soft contact lenses (85.8%).In addition, the majority of patients surveyed were non-Hispanic (85.2%), white (77.7%), and female (59.2%) (Table 1)."
Rubella Immunization
Authors: Louis Weinstein, Te-Wen Chang
Journal: New England Journal of Medicine (1973)

The report in this issue of the Journal by Klock and Rachelfsky indicating failure of herd immunity to prevent a large outbreak of rubella comes as no surprise. At least two other groups of investigators had come to this conclusion previously. Fox and his colleagues1 carried out a mathematical analysis of herd immunity and concluded that "the important determinants of an epidemic were the number of susceptibles plus the number of opportunities for their exposure to the disease, and that if these two variables remained constant, the total number of immune persons in the population had no influence on the . . .
STRESS ULCERS AND BLEEDING
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UVB therapy decreases the adhesive interaction between peripheral blood mononuclear cells and dermal microvascular endothelium, and regulates the differential expression of CD54, VCAM-1, and E-selectin in psoriatic plaques
Authors: J-P. CAI, K. Harris, V. Falanga, J. R. Taylor, Y. H. Chin
Journal: British Journal of Dermatology (1996)
Abstract 791: V-ATPase in glioma stem cells: V1G1 subunit expression correlates with metabolic behavior and mitochondria activity
Authors: Alessandra M. Storaci, Irene Bertolini, Manuela Caroli, Stefano Ferrero, Valentina Vaira
Journal: Cancer Research (2019)

Abstract Background The vacuolar H+-ATPase (V-ATPase) is a multisubunit proton pump with a role in the acidification of the extra- and intra-cellular environments. Recent evidence connected V-ATPase deregulation and human diseases, including cancer. We previously demonstrated that the overexpression of the catalytic subunit V1G1 is correlated with glioma stem cells (GSC) maintenance. According to V1G1 expression, we sorted glioblastoma patients-derived neurospheres cultures (NS) into two categories: V1G1HIGH and V1G1LOW NS. These NS differ in terms of stem cell genes expression, sphere formation, invasion ability, lysosomal acidity and bioenergetics. Methods V1G1HIGH, V1G1LOW NS treated with 10nM of BafilomycinA1 (BafA1) or vehicle for 24h (n=3 per group) were used for the functional experiments. Lactate, glucose, ATP levels were measured by commercial kits. Metabolic proteins expression was assessed by western blot. ROS production and mitochondria function were measured by flow cytometry using MitoSox and TMRE assays, respectively. Results At basal conditions, V1G1LOW NS produce higher levels of lactate (p=0.0379) whereas V1G1HIGH NS show higher levels of extracellular glucose and intracellular ATP. Accordingly, the two NS cultures show an opposite trend in LDH subunits expression with LDHA, which pushes lactate production, being more expressed in V1G1LOW (p=0.0027). Conversely, LDHB that facilities the production of pyruvate from lactate, and the transporter MCT1 are more expressed in V1G1HIGH NS. Interestingly, using the V-ATPase specific inhibitor BafA1, metabolic characteristics of V1G1HIGH are redirected to the V1G1LOW phenotype. Moreover, in V1G1HIGH NS BafA1 induces ROS production and affects mitochondria activity, increasing their depolarization. Conclusions Taken together these data suggest two distinct metabolic behaviors of NS according to V-ATPase expression. Indeed for energy production V1G1LOW NS could rely on a glycolytic metabolism whereas V1G1HIGH NS on oxidative phosphorylation. Moreover, when overexpressed the proton pump could also have a role in preserving mitochondria polarity. Although preliminary, this is the first evidence reporting a role for V-ATPase in the regulation of cancer stem cell metabolism. Citation Format: Alessandra M. Storaci, Irene Bertolini, Manuela Caroli, Stefano Ferrero, Valentina Vaira. V-ATPase in glioma stem cells: V1G1 subunit expression correlates with metabolic behavior and mitochondria activity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 791.
Monitor Passes First Tests With Flying Colors
Authors: A. A. Skolnick
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pemoline abuse
Authors: S. E. Polchert
Journal: JAMA (1985)

Addictive use of the stimulant drug pemoline caused a delusional disorder in a middle-aged man. Discontinuance of use of the drug promptly reversed the psychosis, which subsequently recurred when pemoline was again used. Pemoline seems to be an addictive drug and has an additional property that heretofore has been attributed mainly to amphetamines— precipitation of a paranoid psychosis. (<i>JAMA</i>1985;254:946-947)
Calcium Channel Blockers
Authors: Aram V. Chobanian
Journal: JAMA (1996)

Calcium channel blocking drugs have held great promise for the treatment of a variety of cardiovascular diseases, including angina pectoris, systemic and pulmonary hypertension, certain cardiac arrhythmias, and Raynaud's disease. Their popularity has increased considerably over the past decade and at present, calcium channel blockers are prescribed as frequently for hypertension as are diuretics and angiotensinconverting enzyme (ACE) inhibitors and more than β-blockers.<sup>1</sup>However, although calcium channel blockers represent an important part of the therapeutic armamentarium against cardiovascular diseases, concerns have been raised about these drugs, particularly the short-acting dihydropyridine derivatives. The results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS) reported in this issue of The Journal<sup>2</sup>add to these concerns. See also p 785. MIDAS was a large, randomized, double-blind, and expensive clinical trial that compared the effects of isradipine, a short-acting dihydropyridine, and hydrochlorothiazide on the course of carotid artery disease in hypertensive patients. The
Abstract 1401: PVT1 exon 9 transcript regulates claudin 4 expression and migration in triple negative breast cancer
Authors: Fayola A. Levine, Olorunseun O. Ogunwobi
Journal: Cancer Research (2020)

Abstract Breast cancer (BC) is a heterogeneous disease that is classically driven by the estrogen receptor (ER), progesterone receptor (PR) and human epithelial growth factor receptor 2 (EGFR2/HER2) signaling pathways. Triple negative breast cancer (TNBC), is a lethal subtype of invasive BC tumors that are ER-, PR- and HER2-. A subtype of TNBC is claudin low (CL). Dysregulation of claudin proteins disrupts tight junctions, consequently inducing the epithelial-to-mesenchymal transition (EMT) in cancers. This leads to enhanced motility and metastasis. Patients with CL TNBC have worse prognosis than patients with other BC subtypes. PVT1 is a long noncoding RNA (lncRNA) transcribed from the 8q24 genomic locus that has been implicated in multiple cancers including BC. Amplification of the 8q24 gene locus is a common event in many malignant diseases and is associated with poor clinical outcomes. Although previous research has implicated PVT1 as an important player in BC, the underlying molecular mechanisms of PVT1 in CL TNBC was previously unknown. We assessed PVT1 expression in BC, and we observed that PVT1 exons 4A, 4B, and 9 are significantly upregulated in MDA MB 231 cells (claudin low) and significantly downregulated in MDA MB 468 cells (claudin high), in comparison to T47D (ER+). We have confirmed that claudin expression, specifically claudins 1, 3, 4 and 7, are significantly higher in MDA MB 468 cells and significantly lower in MDA MB 231 cells. Knockdown of PVT1 exon 9 expression in the MDA MB 231 cell line, led to a significant reduction in migration when compared to cells transfected with a control scramble siRNA, indicating that PVT1 exon 9 regulates migration in CL TNBC. Interestingly, we observed that claudin 4 expression, and not claudins 1, 3 and 7, was increased in cells where PVT1 exon 9 was knocked down when compared to the control cells. This indicates that PVT1 exon 9 regulates claudin 4 protein stability in CL TNBC. We also assessed the expression of EMT markers (vimentin, fibronection, and caveolin) in MDA MB 231 cells. We observed no changes in EMT markers when PVT1 exon 9 is knocked down; however, our data suggests that EMT markers are more highly expressed in MDA MB 231 cells in comparison to MDA MB 468 cells. Taken together, our data indicate that PVT1 exon 9 regulates claudin expression and migration in CL TNBC, and may have implications for clinical outcomes in TNBC. Citation Format: Fayola A. Levine, Olorunseun O. Ogunwobi. PVT1 exon 9 transcript regulates claudin 4 expression and migration in triple negative breast cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1401.
THE COLLEGE WOMAN AND CHILDREN.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coronary revascularisation
Authors: David P Taggart
Journal: BMJ (2007)

Coronary revascularisationSurgery is effective on clinical and economic grounds, but stenting does not seem to be cost effective This week, the BMJ publishes three studies dealing with revascularisation in ischaemic heart disease. [1]2][3] Two of the studies compare the clinical effectiveness 1 and cost effectiveness 2 of revascularisation of isolated left anterior descending coronary disease by stenting or surgery, while the third examines the cost effectiveness of medical treatment, stenting, and surgery in multivessel disease. 3 The studies raise key issues not only about the decision making process for intervention in the individual patient but also how to obtain maximum value from limited health service resources.
Contents Vol. 86, 2017
Authors: Giovanni A. Fava, Jenny Guidi, Chiara Rafanelli, Karl Rickels, Fiammetta Cosci, Roland Schaette, Laurence McKenna, Elizabeth M. Marks, Christopher A. Hallsworth, Karen Ritchie, Philippe Courtet, Raffaella Calati, Emilie Olié, Sylvaine Artero, Richard Balon, Markus J. Rantala, Severi Luoto, Indrikis Krams, AdriaanW. Hoogendoorn, Anton J.L.M. van Balkom, Neeltje M. Batelaan, Klaas M. Huijbregts, Paulien Slottje, Giovanni Castellini, Alessio Maria Monteleone, Francesco Rotella, Valdo Ricca, Lorenzo Lelli, Elisa Corsi, Beatrice Campone, Eleonora Ciampi, Alessandra D. Fisher, Luca Mallardo, Tommaso Tofani, Linda Vignozzi, Francesco Zamponi, Mario Maggi, Per Bech, Elena Tomba, Giovanni A. Fava, Otto R.F. Smith, Marit Knapstad, Daniele E. Alves, Leif E. Aarø, Manfred E. Beutel, Rüdiger Zwerenz, Jan Becker, Rudolf J. Knickenberg, Martin Siepmann, Karin Hagen, Dunja Tutus, Cedric Sachser, Lutz Goldbeck, Elisa Pfeiffer, Rita Rosner, Satz Mengensatzproduktion, Druckerei Stückle, Druckerei Stückle
Journal: Psychotherapy and Psychosomatics (2017)