tbuckley/cabot-search huggingface dataset:
Abstract 1351: Ca <sup>2+</sup> Dissociated from Myofilaments Enhances Delayed Afterdepolarizations by Triggering Ca <sup>2+</sup> Waves in Rat Cardiac Muscle
Authors: Masahito Miura, Yuji Wakayama, Hiroaki Shimokawa
Journal: Circulation (2007)

Background: Non-uniform excitation-contraction coupling (ECC) causes arrhythmias by triggering Ca 2+ waves from the border zone (BZ) between contracting and stretched regions. To elucidate the triggering mechanism of Ca 2+ waves under the condition of non-uniform ECC, we examined the role of Ca 2+ dissociated from myofilaments in delayed afterdepolarizations (DADs) and Ca 2+ waves. Methods: Force was measured in 25 rat trabeculae with a strain gauge, sarcomere length with a laser diffraction technique, membrane potential with a ultracompliant microelectrode, and [Ca 2+ ] i with microinjected fura-2 and a CCD camera. To produce non-uniform ECC, a restricted region (~300 μm length) of muscle was exposed to a jet of Hepes solution containing 20 mM 2,3-butanedione monoxime (BDM), causing sarcomere stretch inside the region during twitches. DADs were induced by 7.5 s-2 Hz stimulus trains in the presence or absence of the BDM jet. Streptomycin (100 μM) was then added to eliminate the effect of stretch-activated channels. To modulate myofilament-Ca 2+ affinity inside the BDM jet region, muscle length was varied transiently from 2.0 to 2.1 or 2.2 μm during a twitch by the last stimulus of the trains (24 °C, [Ca 2+ ] o =2.0 mM). Results: The regional exposure of muscle to the BDM jet reduced the twitch force by 41 %, but enhanced DADs (n=6, P&lt;0.05) and aftercontractions (n=6, P&lt;0.05) and occasionally induced action potentials. Streptomycin did not suppress the significant enhancement of DADs and aftercontractions caused by the BDM jet (n=6). Stretch of sarcomere length for 210 ms increased the velocity of Ca 2+ waves and the amplitude of aftercontractions in proportion to the increase in force during the stretch (n=12, r=0.90, P&lt;0.01). In the presence of 1 mM caffeine, quick return of muscle length after the stretch for 400 ms induced a small and quick increase in [Ca 2+ ] i at BZ, whose amplitude was correlated with the change in force during the stretch (n=15, r=0.76, P&lt;0.01). Conclusions: These results suggest that Ca 2+ dissociated from myofilaments due to quick release of active sarcomere enhances DADs by triggering Ca 2+ -induced Ca 2+ release in the BZ and thereby induces triggered arrhythmias. Thus, non-uniform ECC can be arrhythmogenic by the dissociated Ca 2+ in the BZ.
Massachusetts Medical Society
Authors: George E. Morris
Journal: New England Journal of Medicine (1959)

TOXIC HAZARDS*Erysipeloid†Erysipeloid is a sharply circumscribed, slightly elevated, purplish erythema that usually appears on the hands afterpuncture of the skin by an animal bone or in a worker handling living or dead animal matter. It is caused by the inoculation into the skin of the bacillus of swine erysipelas (Erysipelothrix rhusiopathiae). The bacillus may be found in many animals and in game, and so affects abattoir workers, retail butchers and other persons who handle fish, fish bones, meat, hides, manure and fertilizers.The organism is resistant to drying, and persists for long periods in the dry . . .
Doctors; Actors
Authors: Gordon Daugherty
Journal: JAMA (1985)

<h3>To the Editor.—</h3> I enjoyed Gabriela Radulescu's<sup>1</sup>essay in the June 7 issue, but I have sad news. Precedent for the actor-as-expert lies not with television, but with that other comedic institution—the US Congress. It was there several years ago that actor Jack Klugman testified on "orphan drugs." His qualifications were that orphan drugs had been featured on his television show. The art form was raised to a higher level recently with the testimony of a trio of farm policy experts: Jane Fonda, Sissy Spacek, and Jessica Lange. (Ms Fonda is also an authority on foreign policy and nuclear power.) On second thought, I guess it did start with TV; I just remembered the founding father, Robert Young. He doesn't need to say, "I'm not a doctor, but..." No one would believe it, anyway. The key thing is to visualize the reverse of all this in our era of
Endotracheal Intubation
Authors: R. J. LEWIS
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 November 1970Endotracheal IntubationR. J. LEWIS, M.A., B.M., B.CH.R. J. LEWIS, M.A., B.M., B.CH.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-5-856_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sadly, a whole page of correspondence in the August issue of the ANNALS is devoted to advocating the second best (Mask vs Intubation in Resuscitation).If house officers cannot intubate reliably, then it is deplorable. A fraction of the time spent by students assembling intravenous infusions, for example, could allow them to learn efficient endotracheal intubation in the anesthetic room or morgue. As an ancillary benefit the incidence of iatrogenic fluid overload and sepsis would plummet.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R. J. LEWIS, M.A., B.M., B.CH.Affiliations: Division of Infectious Disease Department of Medicine University of Illinois Hospital P.O. Box 6990 Chicago, Ill. 60616 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1970Volume 73, Issue 5Page: 856-856KeywordsAnestheticsIntubationResuscitationSepsis ePublished: 1 December 2008 Issue Published: 1 November 1970 PDF downloadLoading ...
The Fall
Authors: George Young
Journal: Annals of Internal Medicine (1998)

Ad Libitum15 January 1998The FallGeorge Young, MDGeorge Young, MDBoulder, CO 80304Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-2-199801150-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Lie still, birdwith a broken wing.Stop shiveringunder the snow of your winter,this clean white sheet.Your hollowbones are better for flyingthan tottering downthe lonely halls of a nursing homein raggedbathrobe and slippers …where you fell.Nowthere's a magenta bruisein your side,and the little blue riversin the glass-like skin of your templehave spilled bloodin the white feathers of your hair.The nurse will bringsome morphine for your pain.And tomorrowthe orthopedic surgeonwill fix your hip with a pin.You won't fly.But you'll walk again. Author, Article, and Disclosure InformationAffiliations: Boulder, CO 80304Corresponding Author: George Young, MD, 2315 Hawthorn Avenue, Boulder, CO 80304. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1998Volume 128, Issue 2Page: 95KeywordsBloodBoneFallsHipMorphineNursesNursing homesOrthopedicsRiversSurgeons ePublished: 15 August 2000 Issue Published: 15 January 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones
Authors: Cordelia Imig, Sang-Won Min, Stefanie Krinner, Marife Arancillo, Christian Rosenmund, Thomas C. Südhof, JeongSeop Rhee, Nils Brose, Benjamin H. Cooper
Journal: Neuron (2014)
Memoir
Authors: Jason Chao
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA (2019)

Ventilatory Support in Acute Respiratory Distress Syndrome 846There is evidence that titrating positive end-expiratory pressure (PEEP) to off set esophageal pressure (an estimate of pleural pressure) can attenuate lung injury and improve patient outcomes in acute respiratory distress syndrome.Beitler and colleagues for the EPVent-2 Study Group randomized 200 patients with acute respiratory distress syndrome and found that PEEP titration guided by esophageal pressure, compared with a conventional ventilatory strategy, did not improve a composite outcome of mortality and days free from mechanical ventilation.In an Editorial, Cavalcanti and colleagues conclude that a tool in common use for adjusting PEEP and the more invasive, costly, and cumbersome technique tested in this study have similar clinical outcomes.
PROPOSED RESURRECTION OF SHEPPARD-TOWNERISM
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retired physicians are willing to work
Authors: W. B. Rogers
Journal: JAMA (1991)

<h3>To the Editor.</h3> —You are to be congratulated for your outstanding edition on universal health insurance (May 15, 1991). It was well-organized and well thought out, and I deeply appreciate your attention to this topic. As one of the few politicians in this country who practices medicine, I'd like to share the following observations. There are two major faults with many of these plans. The first is that a number of them rely on continuation of the Medicare program. Any practicing physician will tell you that the Medicare program is a disaster. It underreimburses the physicians, it undercompensates the insured patients, and its bureaucracy and interference with medical practice are demoralizing. Second, the major shortcoming of many plans (including that of the American Medical Association) is the lack of serious provision for cost containment. That also applies to the Pepper Commission and many of the other plans that rely on
Utility Restructuring and the Environment
Authors: Linda Birnbaum, Scott Masten
Journal: Environmental Health Perspectives (1997)

Forum ciated with Bt for humans who consume bioengineered foods.Says Beachy, "The risk in food is little or none because this bacterium and its proteins have been in our food chain for many years.To reduce the chemical load on the land by using Bt products far outweighs the potential negative impact." Dioxin in RussiaSix American and Canadian dioxin and environmental specialists met with 40 Russian scientists, NGO representatives, and policy makers over a period of 10 days in October 1996 to discuss dioxin contamina- tion in the environment and in humans.This delegation of experts, which met in the Russian cities of Moscow and Ufa, was orga- nized by CEC International Partners, formally the Citizen Exchange Council, a non- profit group that aids the Newly Independent States (NIS) of the former Soviet Union and 22 countries of Eastern Europe in acquiring knowledge and resources to deal with environmental issues.Looming environmental problems, such as dioxin contamination, have become more apparent since the former Soviet Union opened to the West.
Enzyme Activity Tests Halve Missed Myocardial Infarction
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regulatory effect of nerve growth factor in 9 1 integrin-dependent progression of glioblastoma
Authors: M. C. Brown, I. Staniszewska, P. Lazarovici, G. P. Tuszynski, L. Del Valle, C. Marcinkiewicz
Journal: Neuro-Oncology (2008)

In the present study we described the role of α9β1 integrin in glioblastoma progression following its interaction with nerve growth factor (NGF). The level of expression of α9β1 on astrocytomas is correlated with increased grade of this brain tumor and is highest on glioblastoma, whereas normal astrocytes do not express this integrin. Two glioblastoma cell lines, LN229 and LN18, that are α9β1 integrin positive and negative, respectively, were used for α9β1 integrin–dependent NGF-induced tumor progression. NGF was a significant promoter of promigratory and pro-proliferative activities of glioblastoma cells through direct interaction with α9β1 integrin and activation of MAPK Erk1/2 pathway. The level of NGF increases approximately threefold in the most malignant glioma tissue when compared with normal brain. This increase is related to secretion of NGF by tumor cells. Specific inhibitors of α9β1 integrin or gene silencing inhibited NGF-induced proliferation of LN229 cell line to the level shown by LN18 cells. VLO5 promoted α9β1-dependent programmed cell death by induction of intrinsic apoptosis pathway in cancer cells. LN229 cells were rescued from proapoptotic effect of VLO5 by the presence of NGF. This disintegrin significantly inhibited tumor growth induced by implantation of LN229 cells to the chorioallantoic membrane (CAM) of quail embryonic model, and this inhibitory effect was significantly abolished by the presence of NGF. α9β1 integrin appears to be an interesting target for blocking the progression of malignant gliomas, especially in light of the stimulatory effect of NGF on the development of these tumors and its ability to transfer proapoptotic signals in cancer cells.
Alcohol consumption enhances fatty acid ω-oxidation, with a greater increase in male than in female rats
Authors: X Ma
Journal: Hepatology (1993)

Because ethanol inhibits mitochondrial fatty acid oxidation, with substantial accumulation of fatty acids in the livers of female (but not male) rats, and induces microsomal activities, we assessed possible changes in ω-oxidation. To study this, we pair-fed 24 male and 24 female littermate rats of the same age liquid diets containing 36% of energy either as ethanol or as additional carbohydrate for 4 wk. In controls, the microsomal ω-hydroxylation of lauric acid was 28% greater in female than in male rats (p < 0.05). Ethanol feeding significantly increased this activity in both genders (p < 0.01), but the rise in male rats (89%) was significantly higher than that in female rats (24%). This activity was unaffected by the presence of ethanol in the assay. The effects of ethanol were associated with increases in the content of cytochrome P-450 4A1 (as assessed in Western blots by the reactivity against a sheep antibody against P-450 4A1), and more so in male than in female rats. Despite possible competition by ethanol with the hydroxy fatty acid oxidation to dicarboxylic acids through alcohol dehydrogenase, suberic and sebacic acids accumulated significantly in the livers of alcohol-fed male rats. These effects of ethanol and gender on ω-oxidation paralleled those on the hepatic cytosolic fatty acid-binding protein and fatty acid esterification previously reported in similarly treated rats. Dicarboxylic acid products of ω-oxidation have been incriminated as mediators of similar effects by other drugs. Thus the increase in ω-oxidation may compensate, at least in part, for the deficit in fatty acid oxidation caused by the ethanol-induced injury of the mitochondria by promoting fatty acid binding, esterification and oxidation through alternate pathways. This compensatory effect is less efficient in female than in male rats, which may explain why alcohol administration results in a striking and potentially deleterious accumulation of fatty acids in the livers of female but not of male rats. (HEPATOLOGY 1993;18:1247-1253).
AMA/Glaxo Wellcome Leadership Award Recipients, Part 2
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conscious analgesia and amnesia for cardioversion
Authors: C. E. Reier
Journal: JAMA (1969)

Conscious analgesia (stage I, plane 3) produced by the inhalation of methoxyflurane was used in 20 consecutive patients who underwent 22 elective direct-current countershock procedures for supraventricular arrhythmias. After the drug had been administered in concentrations adequate to produce signs of perseveration, loss of memory, delayed response to verbal commands, and inability to focus eyes, the direct-current countershock was delivered. Although the patients responded to verbal commands just prior to the procedure, postoperative interviews revealed complete amnesia. No significant changes in heart rate, blood pressure, or ventilation were noted. Following the procedure, emergence to an alert, oriented state occurred within two to five minutes. The technique provided both analgesia and amnesia—but without general anesthesia.
Trends in alcohol consumption by pregnant women. 1985 through 1988
Authors: M. Serdula
Journal: JAMA (1991)

To examine trends in alcohol consumption among pregnant women, we examined data collected from 21 states participating in the Behavioral Risk Factor Surveillance System for 4 consecutive years: 1985 through 1988. Overall, 429 (25%) of 1712 pregnant women and 19 903 (55%) of 36 057 nonpregnant women 18 to 45 years of age reported using alcohol in the previous month. Pregnant women who used any alcohol reported consuming a median of four drinks per month, whereas nonpregnant women who used any alcohol reported nine. The prevalence of alcohol consumption among pregnant women declined steadily, from 32% in 1985 to 20% in 1988, but the median number of drinks per month for pregnant women who drank did not change. No decline was observed among the less educated or those under the age of 25 years. In 1988, the prevalence of alcohol use among pregnant women remained highest among smokers (37%) and the unmarried (28%). Although the overall consumption of alcohol by pregnant women in the United States appears to be declining, special efforts are needed to reduce alcohol use among pregnant women who are smokers, unmarried, less educated, or younger, women who may already be at high risk of a poor pregnancy outcome. (<i>JAMA</i>. 1991;265:876-879)
Perspectives on Testing for Toxic Agents
Authors: Norton Nelson
Journal: Environmental Health Perspectives (1987)

A series of observations and comments are made with respect to several areas of toxicology: these are briefly discussed. Some innovative areas receive discussion as representing substantial progress made in the field of toxicology in recent years. Topics included raise a number of questions: what agents should we test, and how should we go about selecting them; what is the importance of allowing for genetic diversity in carrying out tests that are meaningful for humans; and what is the relevance of studies in pharmacokinetics in the laboratory to humans. Human studies, because of ethical considerations, must be indirect, through access to available autopsy and surgical human tissues. Also, drug trials and clinical studies must be exploited. Cancer testing and evaluation is briefly commented on. Systemic toxicity is considered in respect to possible improved ways of determining the "NOEL," that is, the no-observed-effect level. Suggestions for improving study of mixtures of chemicals are considered. The rapid advances in molecular biology have significantly strengthened our ability to trace the action of chemicals in the body from exposure to disease. It is very important that training in toxicology be based on a sound disciplinary training in one of the classic fields of the biomedical sciences, such as biochemistry, pharmacology, molecular biology. It is concluded that advances in the past decade have made the practice of toxicology a much more scientific endeavor, especially in its use of the latest developments in basic biomedical sciences.