tbuckley/cabot-search huggingface dataset:
Acute Nonoccupational Pesticide-Related Illness and Injury — United States, 2007–2011
Authors: Gonza Namulanda, Michele M. Monti, Prakash Mulay, Sheila Higgins, Michelle Lackovic, Abby Schwartz, Joanne Bonnar Prado, Justin Waltz, Yvette Mitchell, Geoffrey M. Calvert
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

CDC's National Institute for Occupational Safety and Health (NIOSH) collects data on acute pesticide-related illness and injury reported by 12 states (California, Florida, Iowa, Louisiana, Michigan, North Carolina, Nebraska, New Mexico, New York, Oregon, Texas, and Washington). This report summarizes the data on illnesses and injuries arising from nonoccupational exposure to conventional pesticides that were reported during 2007-2011. Conventional pesticides include insecticides, herbicides, fungicides, and fumigants. They exclude disinfectants (e.g., chlorine and hypochlorites) and biological pesticides (1). This report is a part of the Summary of Notifiable Noninfectious Conditions and Disease Outbreaks - United States, which encompasses various surveillance years but is being published in 2016 (2). The Summary of Notifiable Noninfectious Conditions and Disease Outbreaks appears in the same volume of MMWR as the annual Summary of Notifiable Infectious Diseases (3). In a separate report, data on illnesses and injuries from occupational exposure to conventional pesticides during 2007-2011 are summarized (4).
INTRAGASTRIC CONDUCTANCE
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Croonian Lectures on the Numerical Method, and its Application to the Science and Art of Medicine
Authors: W. A. Guy
Journal: BMJ (1860)

The Science of Medicine and the Art of Healing the most difficult of all the Sciences and Arts.Human Beings, the Objects of our Study, differ widely from each other.Causes of that difference in Health and in Disease.Summary of the Causes which render the Science of Medicine and the Art of Healing so difficult and uncertain.These Diffi-
Cardiac effects of doxorubicin therapy of neoplasms
Authors: R. J. Ugoretz
Journal: JAMA (1976)

PROGRESS in cancer chemotherapy has been attended by a challenging variety of potentially toxic side effects. The recent entry of the antitumor antibiotic doxorubicin hydrochloride (Adriamycin) in the standard formulary has added drug-induced cardiac damage to the realm of clinical cardiology. A product of the microbe streptomyces peucetius var<i>caesius</i>, this anthracycline compound has achieved an important role in the therapy of soft tissue sarcoma and advanced breast cancer. It also is active in acute leukemia, malignant lymphoma and an unusually wide variety of solid tumors.<sup>1</sup>Doxorubicin differs only by 14-hydroxylation from daunomycin, which shares only the potential for producing cardiac damage but not the wide spectrum of antitumor activity. Daunomycin still is an investigational compound. Bone-marrow suppression and the risk of severe mucositis limit the size and frequency of individual doses of doxorubicin. A commonly employed dose schedule in the treatment of adults has called for a single
DISCUSSION ON DR. F. A. PACKARD'S PAPER "TRICHINOSIS IN THE UNITED STATES."
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diseases and Injuries of the Larynx: A Textbook for Students and Practitioners
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family tension in the search for a kidney donor
Authors: R. G. Simmons
Journal: JAMA (1971)

The search for a kidney transplant donor is a significant decision-making stress for many extended families. The family is asked to donate the kidney of one member to save the life of another. Seventy-nine cases were reviewed and family tension is noted in 21 of these. It is concluded that earlier studies have minimized the nature of this crisis, because they have not focused on the family as an interacting unit or on the nondonor—the family member who "could" donate but does not.
Trends in death with tuberculosis during the AIDS era
Authors: M. M. Braun
Journal: JAMA (1993)

<h3>Objective.</h3> —To describe and analyze recent changes in tuberculosis mortality in the United States during the acquired immunodeficiency syndrome (AIDS) epidemic. <h3>Design.</h3> —We used National Center for Health Statistics multiple-cause mortality data and analyzed deaths with tuberculosis (1980 through 1990) and/or AIDS (1987 through 1990) as an underlying or associated cause. We also categorized the 50 states and the District of Columbia into high (five states), medium (23 states), and low (23 states) AIDS incidence groups and then compared the groups' rates of death with tuberculosis during the period 1980 through 1990. <h3>Study Population.</h3> —Residents of the United States who died in the period 1980 through 1990. <h3>Main Outcome Measures.</h3> —Death certificates indicating AIDS and/or tuberculosis. <h3>Results.</h3> —A bimodal age distribution of persons dying with tuberculosis has emerged concurrent with the AIDS epidemic. A new peak spanning the ages 20 to 49 years accompanies the preexisting peak in the elderly. In 1990, 54.2% (729/1344) of the deaths with tuberculosis in persons 20 to 49 years of age occurred in persons who also had AIDS listed on their death certificates. During the period 1987 through 1990, there was an increasing trend in the proportion of AIDS deaths that also had tuberculosis: 2.3% (353/15075) in 1987, 2.5% (460/18649) in 1988, 3.0% (738/24607) in 1989, and 3.0% (836/27975) in 1990 (<i>P</i>&lt;.001). Of AIDS deaths in 1990,1.6% (253/15 565) of whites died with tuberculosis, compared with 4.7% (400/8533) of blacks (<i>P</i>&lt;.001) and 4.7% (172/3666) of Hispanics (<i>P</i>&lt;.001). In the high AIDS incidence states, the rate of death with tuberculosis in persons aged 20 to 49 years rose from 0.61 to 2.82 per 100 000 population in the period 1982 through 1990, an increase of 362%. For this age group in the states with medium and low AIDS incidence, the rates of death with tuberculosis during this period rose 52% and 47% (from 0.44 to 0.67 and from 0.19 to 0.28 per 100000 population), respectively. The increases in the rate of death with tuberculosis within all three groups and the differences among the groups were all highly statistically significant (<i>P</i>&lt;.001). <h3>Conclusion.</h3> —The AIDS epidemic has significantly increased the number and rate of tuberculosis deaths in younger adults through 1990, although in this study discrimination of deaths<i>due to</i>tuberculosis from deaths<i>with</i>tuberculosis was not possible. Vigorous efforts to prevent and treat tuberculosis and AIDS are indicated to reverse the trends we have described. (<i>JAMA</i>. 1993;269:2865-2868)
Reply
Authors: Shernaz Walton, E.H. Wyatt, W.J Cunliffe
Journal: British Journal of Dermatology (1989)

Journal Article Reply Get access Shernaz Walton, Shernaz Walton Department of Dermatology, Hull Royal Infirmary, Hull, U.K. Search for other works by this author on: Oxford Academic Google Scholar E.H. Wyatt, E.H. Wyatt Department of Dermatology, Hull Royal Infirmary, Hull, U.K. Search for other works by this author on: Oxford Academic Google Scholar W.J Cunliffe W.J Cunliffe Department of Dermatology, The General Infirmary, Leeds, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 1, 1 July 1989, Pages 144–145, https://doi.org/10.1111/j.1365-2133.1989.tb01414.x Published: 01 July 1989
Contraception and infertility.
Authors: K L Oldershaw, M Brudenell
Journal: BMJ (1972)

be used to control unwanted behaviour and encourage specific skills.Group work with the parents can be conductedparents confronting and being confronted with both the impact of the child on themselves, and the effect of their attitudes on their children's behaviour-while individual therapy can help children or parents to understand their feelings or reactions.Parents' groups'0 are being conducted in several centres with a variety of problems, and this may be a method of giving support and understanding when current and future crises occur before they become intense.Finally, drugs may be needed for the brain-damaged over- active impulsive child.As the child approaches school age the parent may have to face the necessity for special educa- tion.They once more become aware of the discrepancy be- tween their expectations and reality.With adequate pre-school educational provisions, and satisfactory solutions of earlier crises it should be possible for the transition to be less pain- ful.Physical or mental impairment should not handicap the future emotional adjustment and development of the child.
Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249
Authors: D Oguey
Journal: Hepatology (1996)

Chronic infection with hepatitis B virus (HBV) is associated with the development of human hepatocellular carcinoma (HCC). One of the HBV genes, HBx, may have transforming potential, but this issue is still the subject of controversy. One of the major difficulties in addressing this question is the lack of a suitable in vitro model. We used a nontransformed, differentiated murine hepatocyte cell line (AML12) to transfect the HBx gene and examine its transforming capabilities. Because mutations of the p53 gene, in particular at codon 249, have been implicated in HCC development in geographical areas with high incidence of the tumor, we also studied the putative cooperative role in transformation between HBx and mutated p53 by cotransfecting HBx with a murine p53 mutant equivalent to human ser249 (ser246p53). Transfection with HBx plasmids containing the HBx gene under the control of two different promoters resulted in fewer colonies than in control plasmids. The toxic effect of HBx on colony formation was abolished by cotransfection with 246p53, suggesting that the inhibitory effect requires functionally intact p53. Clonal cell lines that stably expressed HBx messenger RNA (mRNA) (HBX lines) were tested for their growth characteristics and their ability to grow in soft agar and form tumors in nude mice. At passages 19-27 after transfection, one of four HBx-expressing lines showed the capacity for anchorage-independent growth in soft agar and produced poorly differentiated hepatocellular carcinomas in 8 of 13 sites of injection in nude mice. HBX lines as well as clonal cell lines of cells transfected with 246p53 (246 cell lines), cotransfected with HBx and 246p53 (246x lines) or transfected with control plasmids, were analyzed by flow cytometry to determine the fraction of cells in S phase (SPF). 246 and 246X lines had similar SPFs that were approximately twofold greater than control or HBX lines. 246x lines showed morphological changes in culture such as marked cellular heterogeneity, cell crowding, and the presence of multinucleated giant cells, but their tumorigenicity was not increased compared with the HBX lines. These data show that HBx has a weak tumorigenicity in murine hepatocytes and that the addition of mutation of p53 at codon 249 to HBx expression does not increase tumorigenicity in AML12 cells.
Phase III study of gemcitabine/oxaliplatin (GEMOX) with or without erlotinib in unresectable, metastatic biliary tract carcinoma.
Authors: H. Y. Lim, J. Lee, H. Chang, J. S. Kim, H. J. Choi, M. A. Lee, J. Jang, H. Jeung, J. H. Kang, H. W. Lee, D. Shin, H. J. Jang, J. Sun, S. H. Park, J. O. Park, Y. Park, W. K. Kang
Journal: Journal of Clinical Oncology (2011)

LBA4032 The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed onsite at the Meeting on June 4, 2011, and as a supplement to the June 20, 2011, issue of Journal of Clinical Oncology.
Price Omission
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poet's Corner
Authors: Irene Warsaw
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Notice to Readers:</i> Special Podcast: “Defining Moments in <i>MMWR</i> History — <i>E. coli</i> O157:H7”
Authors: Sonja Rasmussen
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

MMWR has released a special podcast that highlights the leading role that MMWR played in reporting on the deadly multistate Escherichia coli O157:H7 foodborne outbreak of 1993. "Defining Moments in MMWR History - E. coli O157:H7" features an interview with Dr. Beth Bell conducted by MMWR Editor-in-Chief Dr. Sonja Rasmussen. Dr. Bell, who served as director of the National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) from 2010 to 2017 and as an Epidemic Intelligence Service Officer during 1992-1994, was one of the first public health responders on the scene for this landmark public health emergency.
Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity
Authors: N. van Erp, R. H. Mathijssen, A. A. van der Veldt, J. B. Haanen, A. K. Reyners, K. Eechoute, E. Boven, J. A. Wessels, H. Guchelaar, H. Gelderblom
Journal: Journal of Clinical Oncology (2009)

5006 Background: To identify genetic markers in the pharmacokinetic and pharmacodynamic pathways of sunitinib that predispose for development of toxicities; thrombocytopenia, leukopenia, mucosal inflammation, hand-foot syndrome and ‘any toxicity according to Common Terminology Criteria &gt; grade 2.’ Methods: A multicenter pharmacogenetic association study was performed in 219 patients treated with single agent sunitinib. A total of 31 single nucleotide polymorphisms in 12 candidate genes, together with several non-genetic variants, were analyzed for a possible association with toxicity. In addition, genetic haplotypes were developed and related to toxicity. Results: The risk for leukopenia was increased when the G-allele in CYP1A1 2455A/G (OR = 6.24; p = 0.029) or the T-allele in FLT3 738T/C (OR = 2.8; p = 0.008) were present or CAG in the NR1I3 (5719C/T, 7738A/C, 7837T/G) haplotype (OR = 1.74; p = 0.041) was absent. ‘Any toxicity &gt; grade 2’ prevalence was increased when the T-allele of VEGFR-2 1191C/T (OR = 2.39; p = 0.046) or a copy of TT in the ABCG2 (-15622C/T, 1143C/T) haplotype (OR = 2.63; p = 0.016) were present. The risk for mucosal inflammation was increased in the presence of the G-allele in CYP1A1 2455A/G (OR = 4.03; p = 0.021) and the prevalence of hand-foot syndrome was increased when a copy of TTT in the ABCB1 (3435C/T, 1236C/T, 2677G/T) haplotype (OR = 2.56; p = 0.035) was present. Conclusions: This exploratory study suggests that polymorphisms in specific genes encoding for metabolizing enzymes, efflux transporters and drug targets are associated with sunitinib related toxicities. A better understanding of genetic and non-genetic determinants of sunitinib toxicity should help to optimize drug treatment in individual patients. [Table: see text]
Locally Acquired Neurocysticercosis
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Journal: JNCI Journal of the National Cancer Institute (1992)

“Overexpression of the MDRI Gene and P-Glycoprotein in Human Hepatocellular Carcinoma,” by C. Huang, M. Wu, G. Xu, et al. [J Natl Cancer Inst 84:262–264, 1992 (issue 4)]. The authors wish to substitute the following for Fig. 2 (labels across top of Fig. have been corrected):
Book Review Surgical Anatomy of the Head and Neck . By John Finch Barnhill, M.D., LL.D., and William J. Mellinger, M.D. Introduction by Paul S. McKibben. Second edition, rearranged and revised. 4°, cloth, 773 pp., with 431 illustrations. Baltimore: Williams and Wilkins Company, 1940. $15.00.
Journal: New England Journal of Medicine (1941)