tbuckley/cabot-search huggingface dataset:
Natural killer cells involved in lymphomatoid granulomatosis
Authors: J.D. Bos, J.H. Sillevis Smitt, R. Koopmans, P.M. Bakker
Journal: British Journal of Dermatology (1984)

Journal Article Natural killer cells involved in lymphomatoid granulomatosis Get access J.D. Bos, J.D. Bos Departments Dermatology, of University of Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar J.H. Sillevis Smitt, J.H. Sillevis Smitt Departments Dermatology, of University of Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar R. Koopmans, R. Koopmans Departments of Pathology, University of Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar P.M. Bakker P.M. Bakker Departments of Pathology, University of Amsterdam, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 110, Issue 3, 1 March 1984, Pages 379–380, https://doi.org/10.1111/j.1365-2133.1984.tb04649.x Published: 01 March 1984
Melorheostosis
Authors: TJIEN BO JAP, HAROLD LIPSCHUTZ, CAROL MEYERS, JULIUS HEYDEMANN, ANDREI DRAGOMER
Journal: Clinical Nuclear Medicine (1977)

BO JAP, TJIEN M.D.1; LIPSCHUTZ, HAROLD M.D.*; MEYERS, CAROL M.D.1; HEYDEMANN, JULIUS M.D.1; DRAGOMER, ANDREI M.D.1 Author Information
Abstract 1021: <i>In Vivo</i> Immune Response To Allogeneic Porcine Mesenchymal Stem Cell (msc) Transplantation: A 12-day Course Of Fk-506 Abbrogates Humoral Response.
Authors: Alain J Poncelet, Johnatan Vercruysse, Alain Saliez, Pierre Gianello
Journal: Circulation (2007)

Purpose Several reports have highlighted the low immunogenic profile of MSCs. Therefore, we decided to test in vivo the humoral response to allogeneic MSCs transplantation and the effect of transient immunosuppression in a porcine model. Methods/Material MHC-controlled mini-swine SLA cd and SLA dd were used as donor and recipients, respectively. Two sites of transplantation were selected: subcutaneous and intracardiac. In our control group (n = 5), animals received no immunosuppression. In the study group (n = 11), nearly 1 x 10 6 allogeneic MSC/kg were injected. FK-506 was given from day 0 –12 and adjusted to therapeutic blood levels. Sera were serially collected up to one year after transplantation. The presence of specific anti-donor IgM and IgG was tested by flow cytometry and by a complement-mediated cytotoxicity assay. Results In the control group, all animals developed humoral responses in both IgM/G classes that persisted up to ten weeks. When transplanted subcutaneously, a single injection failed to elicit a complement-mediated cytotoxic response but subsequent re-challenge did. In the study group, only 2/11 FK-treated animals developed a transient humoral response, both in IgM and IgG, whereas all others failed to develop donor-specific antibodies. However, none of the sera tested from those 11 animals could elicit a complement-mediated cytotoxic response. Conclusion Allogeneic MSCs injected subcutaneously or intra-cardially can elicit prolonged humoral responses despite their putative low immunogenic profile. As already shown for experimental allogeneic organ transplantation, a transient immunosuppressive regimen can overcome the initial B cell response. Our result suggests that in vitro and in vivo characteristics of MSCs might differ and emphasizes the importance of pursuing research on allogeneic stem cell transplantation.
OBSERVATIONS ON THE HEART IN DIPHTHERIA
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Natural history of untreated patients who had metastatic biliary tract cancer (BTC) with good performance status (PS).
Authors: Jun Ho Ji, Jung Hun Kang, Se Hoon Park, Su Jin Lee, Soon Il Lee, Sung Yong Oh, In Gyu Hwang
Journal: Journal of Clinical Oncology (2014)

e15106 Background: Although gemcitabine-based chemotherapy is widely recommended to the patients with metastatic biliary tract cancer, the strong evidence for clinical benefit of chemotherapy is far from enough. The natural course of BTC patients with good PS who are usually for chemotherapy was rarely known. Methods: We retrospectively reviewed metastatic or locally advanced BTC patients seen between January 2005 and September 2013 at six cancer centers. Patients were eligible if they had good PS (ECOG 0-2), no history of surgery, chemotherapy, radiotherapy or any treatment for cancer. Primary object was to evaluate survival time and secondary objectives were to examine survival difference among other variables. Results: Of the 1,677 screened patients, a total of 1,612 met the eligibility criteria. Median overall survival (OS) was 7.1 months and Patients with metastatic BTC had a poor prognosis with median 6.2 months and locally advanced BTC had a good prognosis with 13,0 months. (P=0.001) Baseline CA 19-9 elevation (100U/mL) also showed poor survival. (6.0 months vs 10.6 months, P=0.001) The better performance status tended to the longer survival time, but there was not statistically significant difference. (P=0.101). The median surival times of other variables show no statistically significant differences. Conclusions: Metastatic BTC cancer with good PS showed modest survival without any treatment for primary cancer. Furthermore, subgroup analysis showed that patients with normal CA19-9 level or locally advanced status had favorable survival. Further studies comparing chemotherapeutic effect with BSC in patients with unresectable BTC are warranted.
Hospital Meets Emergency Overload
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SURGEON-GENERAL GORGAS AND THE RESPONSIBILITY OF THE MEDICAL DEPARTMENT OF THE ARMY
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Validation of Biological Markers for Quantitative Risk Assessment
Authors: Paul Schulte, Lawrence F. Mazzuckelli
Journal: Environmental Health Perspectives (1991)

The evaluation of iolgia markers is recoied as necsry to the future oftokcOy , epideniology, and q Iive risk assment.For bio cl nmrkes to becm widely accepted, their validity must be ascertained.This paper explores the range ofconsiderations that compose the concept of validiBt as it applies to the evaluation of bioogical markers.Three broad categories of validity (meaem ent, internal study, and external) are discussed in the context of evWaluating data for use inquantitative risk at.Frticular attention is given to the importnce ofmeuement validity in the con- sideration ofwhether to use biological markers in epidemiologic studies.The concepts developed in this presentation are applied to examples derived from the occupational environment.In the first example, measurement of bromine release as a marker ofethylene dibromide toxicity is shown to be of limited use in constructng an accurate quantitative assess- ment ofthe risk ofdeveloping cancer as a reslt of long-term, low-level exposure.This example is compared to data ob- tained from studies ofethylene ade, in which hemoglobin alkylation is shown to be a valid marker ofboth exposure and effect.
Epidermoid cyst of the skull causing displacement of brain
Authors: R. C. Swisher
Journal: JAMA (1969)

An epidermoid cyst of the calvarium is usually an incidental roentgenographic finding. Only rarely does this lesion become large enough to cause sufficient deformity to require surgical removal. Two cases presented show marked brain displacement and orbital erosion. The first patient died of unrelated causes, and the second patient had successful surgical removal of the cyst.
NORMAL MIND.
Authors: J. SANDERSON CHRISTISON
Journal: JAMA (1896)

<h3>PREFACE.</h3> The scope of this article is little more than a suggestive outline of the subject in a fragmentary form. While some of my positions may be regarded as neither proven or self-evident, I am persuaded their correctness will become manifest on a careful consideration. At a later date I expect to deal more fully with some of the points under other headings. I have treated the question by contrast which will give a more accurate view than could otherwise result. <h3>DEFINITION.</h3> By the term normal mind I mean the prompt and coördinate action of all the mental faculties coexisting with pacific disposition or temper. It has no reference to knowledge in the numerical sense, nor capacity in the geometrical sense, but simply that state of mind which enables the individual to do his best in any given relation. <h3>GENERAL ASPECT.</h3> Of ten business or professional men selected at random,
Diabetic cholecystomegaly
Authors: A. A. Bloom
Journal: JAMA (1969)

In three patients with diabetes, gallbladders were enlarged three to nine times normal size. In a series of patients with diabetes, four (16%) of the 25 studied had enlarged gallbladders, while no examples of this could be demonstrated in the 50 control patients. No correlation was demonstrated between cholecystomegaly and other manifestations of diabetes, severity of diabetes, or mode of therapy. The condition resembles cholecystomegaly induced by vagotomy, but other mechanisms remain to be excluded. At the present time, neither medical nor surgical therapy for this condition appears warranted.
Book Listings
Journal: Annals of Internal Medicine (2001)

Book Listings4 December 2001Book ListingsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-11-200112040-00031 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail CardiologyCardioFaxDA Tighe, JR Cook, MJ Schweiger, and EK Chung. 239 pages. Cambridge, MA: Blackwell Science; 2001. $30.00. ISBN 0865425639. Order phone 800-759-6102.Coronary Artery Stenting: A Case-Oriented ApproachN Curzen and MT Rothman, eds. 194 pages. Philadelphia: Taylor & Francis; 2001. $120.00. ISBN 1853177180. Order phone 800-821-8312.Evidence-Based Manual of Coronary Care ManagementM Connaughton. 195 pages. Philadelphia: WB Saunders; 2001. $35.00. ISBN 0443064156. Order phone 215-238-7800.Fundamental Approaches to the Management of Cardiac ArrhythmiasRJ Sung and MR Lauer. 804 pages. Boston: Kluwer; 2000. $350.00. ISBN 0792365593. Order phone 781-871-1660.Heart Disease: Review and Assessment4th edition. LS Lilly. 268 pages. Philadelphia: ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 December 2001Volume 135, Issue 11Page: B1KeywordsBehaviorCellsPrevention, policy, and public health ePublished: 4 December 2001 Issue Published: 4 December 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.Loading ...
Drug Labelling
Authors: S. L. Simpson
Journal: BMJ (1962)

<h3>Abstract</h3> <h3>Background</h3> The aims of this study were to: 1) describe the proportions of vulnerable persons identified by three existing aging metrics that incorporate cognitive and physical function; 2) examine the associations of the three metrics with mortality; and 3) develop and validate a new simple functional score for mortality prediction. <h3>Methods</h3> The three aging metrics were the combined presence of cognitive impairment and physical frailty (CI-PF), the frailty index (FI), and the motoric cognitive risk syndrome (MCR). We operationalized them with data from two large cohort studies: the China Health and Retirement Longitudinal Study (CHARLS) and the US National Health and Nutrition Examination Survey (NHANES). Logistic regression models or Cox proportional hazard regression models, and receiver operating characteristic curves were used to examine the associations of the three metrics with mortality. A new functional score was developed and validated in the Rugao Ageing Study (RAS), an independent dataset. <h3>Results</h3> In CHARLS, the proportions of vulnerable persons identified by CI-PF, FI, and MCR were 2.2%, 16.6%, and 19.6%, respectively. Each metric predicted mortality after adjustment for age and sex, with some variations in the strength of the associations (CI-PF, odds ratio (OR)=2.87, 95% confidence interval (CI)=1.74, 4.74; FI, OR=1.94, 95% CI=1.50, 2.50; MCR, OR=1.27, 95% CI=1.00, 1.62). CI-PF and FI had additional predictive utility beyond age and sex, as demonstrated by integrated discrimination improvement, and continuous net reclassification improvement (all P &lt;0.001). These results were replicated in NHANES. Furthermore, we developed a new functional score by selecting six self-reported items from CI-PF and FI in CHARLS, and demonstrated that it predicted mortality risk. This functional score was further validated in RAS. To facilitate the quick screening of persons with deteriorations in cognitive and physical function, we introduced a publicly available online tool designed for this new functional score. <h3>Conclusions</h3> Despite the inherent differences in the aging metrics incorporating cognitive and physical function, they consistently capture mortality risk. The findings support the incorporation of cognitive and physical function for risk stratification in both Chinese and US persons, but call for caution when applying them in specific study settings.
Teaching nutrition.
Authors: H Vaishnava
Journal: BMJ (1972)

days may be useful.If the flap necroses it must be removed early as described, but in favourable cases the flap will survive and grafting will be avoided.Spontaneous heal- ing will occur under a Viscopaste bandage with the patient ambulant.I cannot under- stand why Mr. David uses the medial aspect of the thigh as a donor site.The postero- lateral aspect is muwh safer to use, but in the elderly the deltoid region is even better as it allows early ambulation.-Iam, etc.,
ABC of Breast Diseases: Breast Cancer
Authors: J R C Sainsbury, T J Anderson, D A L Morgan, J M Dixon
Journal: BMJ (1994)

Breast cancers are derived from the epithelial cells that line the terminal duct lobular unit.Cancer cells that remain within the basement membrane of the elements of the terminal duct lobular unit a W g and the draining duct are classified as in situ or non-invasive.An invasive breast cancer is one in which there is dissemination of cancer g | > r Xf fW4cells outside the basement membrane of the ducts and lobules into the surrounding adjacent normal tissue.Both in situ and invasive cancers have characteristic patterns by which they can be classified.Carcinoma in situ affecting a breast lobule. Classification of invasive breast cancersThe most commonly used classification of invasive breast cancers Classification of invasive breast divides them into ductal and lobular types.This classification was cancers based on the belief that ductal carcinomas arose from ducts and Special types lobular carcinomas from lobules.We now know that invasive ductal * Tubular * Cribriform * Medullary and lobular breast cancers both arise from the terminal duct lobular * Mucoid * Papillary * Classic Lobular unit, and this terminology is no longer appropriate.Some tumours show distinct patterns of growth and cellular morphology, and on thisNo special type basis certain types of breast cancer can be identified.Those with othermmse slyknoed) as NST or NOS (not specific features are called invasive carcinomas of special type, while * Useful prognostic information can be the remainder are considered to be of no special type.This * Single clinical and mammographic lesion * Tumour s4 cm in diameter * No sign of local advancement (T,, T, <4 cm),extensive nodal involvement (No, N1), or metastases (M0) * Tumour >4 cm in large breast * Axillary lymph node involvement * Lymphatic or vascular invasion by cancer * Grade Ill carcinoma * Tumour >4 cm in diameter (pathological) Follow up schedule after surgery for breast cancer Breast conservation surgery Review every six months Mastectomy Review every six months for first two years and annually thereafter
Neurosurgery
Authors: Deborah L. Benzil
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progress in lipid reporting practices and reliability of blood cholesterol measurement in clinical laboratories in Nebraska. Efforts to align results with the Centers for Disease Control, and feasibility of meeting National Cholesterol Education Program Guidelines
Authors: B. M. McManus
Journal: JAMA (1989)

The National Cholesterol Education Program has recommended that all laboratories be consistent, precise, and accurate in the reporting and measurement of blood cholesterol levels. In a follow-up to a 1984 survey study, we assessed the changes in reporting procedures for measurements of blood lipid levels in 16 clinical laboratories in Nebraska. Using human serum reference materials of known cholesterol concentrations provided by the Centers for Disease Control, we also assessed the precision and accuracy of measurement of blood cholesterol levels in clinical laboratories in Nebraska. Fourteen of the 16 laboratories restudied in 1987 had altered the reference range for total serum cholesterol since 1984,86% of whom lowered the upper limit of the reference range. Eleven of 16 laboratories expressed reference ranges for total serum cholesterol in terms of patient age in 1987, while only 7 of 20 did in 1984. Gender-based reference ranges increased from 0 to 5 from 1984 to 1987. Similar trends were seen in the reporting of high-density lipoprotein cholesterol and triglyceride concentrations. Reporting procedures varied greatly; only 1 laboratory used National Cholesterol Education Program risk levels for measuring total serum cholesterol levels. Fifteen laboratories met the National Cholesterol Education Program recommendation for precision (coefficient of variation, ≤5%) and 78% of laboratories obtained results that satisfied the current recommendation for accuracy (within 5% of "true value," as determined by the Centers for Disease Control). (<i>JAMA</i>. 1989;262:83-88)
Neumología y Cirugía de Tórax, Mexico
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal