The normal range and determinants of the intrinsic heart rate in man
Authors: T Opthof
Journal: Cardiovascular Research (2000)

As Editors we are forced to look back at the paper of incorporated in the title by the authors.They did not only Jose and Collison [1] ourselves, because we were not study ''intrinsic heart rate'', which they defined as the successful in retracing Drs.Jose or Collison.Their study heart rate under the simultaneous presence of the nonselecon the normal range and the determinants of the intrinsic tive b-adrenoceptor antagonist propranolol (0.2 mg / kg) heart rate in man was published in 1970.The study was and the muscarinic receptor blocker atropine (0.04 mg / performed in ''healthy volunteers'': 80% of them were kg), but they also established the inverse relation between inmates of the New South Wales State Penitentiary.The age and intrinsic heart rate, both in males and females.The other 20% were members of the hospital staff or medical authors also demonstrated that the variability between students.The majority of subjects were male (73%), individuals is of the same order as the effect of aging in probably reflecting the ratio between male and female the whole population.This might have been emphasized inmates.The paper did not receive much attention during more by the authors, because this limits the significance of the first 10 years after publication.The citation frequency measurement of intrinsic heart rate to serial measurements was about two citations per year during that period.in the same individuals.However, the citation frequency increased after 1980The data of Jose and Collison [1] have later been leading to a total of 200 between 1971 and 1998 (see also confirmed by Alboni et al. in 1982 [3].The youngest Introductory Editorial [2]).We have analyzed the titles of individuals in the study of Jose and Collison were 16 99 papers that cited the original paper by Jose and Collison years.An extension to younger age has been provided by between 1988 and 1999.We found that 33% of those Marcus et al. in 1990 [4].papers either were on sinus node dysfunction or on sinus Again in retrospect it is of interest to note that the node function during some pathophysiological state (e.g.pharmacological concept of intrinsic heart rate had been ischemia or atrial fibrillation).Another 20% of those citing raised by previous work of Jose published in 1966 [5] and papers dealt with syncope or autonomic balance.Aging of Jose and Taylor published in 1969 [6].In those studies contributed 17%, heart rate variability 9%, cardiac trans--directed to normal individuals as well as to patients plantation 7% and gender 4%.Interestingly, the studies on with heart failure -it had already been established that aging, heart rate variability and gender that cited the paper heart rate becomes constant under the combined presence of Jose and Collison were more numerous during the of atropine and propranolol.Jose and Taylor [6] showed second half than during the first half of this 1988-1999 that the intrinsic heart rate is much lower in class III / IV time window, probably reflecting the increased awareness patients (77 beats / min) than in control patients (107 beats / that (intrinsic) heart rate constitutes an important parameter min).The averaged age of the two groups was 50 and 25 for these research topics.years respectively.Since age decreases the intrinsic heart In retrospect the paper of Jose and Collison included an rate by 0.57 beats / min according to the data of Jose and important piece of information that should have been Collison [1], the age difference between the groups explained 14 beats / min of the difference between the normal group and the group with severe heart failure.In