tbuckley/cabot-search huggingface dataset:
The myth of involutional melancholia
Authors: M. M. Weissman
Journal: JAMA (1979)

Depressions occurring in the menopausal years do not fit the description in the American Psychiatric Association's<i>Diagnostic and Statistical Manual of Mental Disorders</i>, edition 2. Depressed patients who are in the menopausal years do not have a distinct symptom pattern, an absence of previous episodes, or an absence of life-stress precipitants. The evidence thus far supports the decision to exclude involutional melancholia, as currently defined, from the forthcoming<i>Diagnostic and Statistical Manual of Mental Disorders</i>, edition 3. (<i>JAMA</i>242:742-744, 1979)
Medical ethics. Ever old, ever new
Authors: T. E. Nesbitt
Journal: JAMA (1981)

NO AREA of medicine is more ancient and established than its ethics—yet more current and alterable. Formalized medical ethics are at least as old as the Code of Hammurabi, King of Babylon. In comparison, the Oath of Hippocrates is a latecomer. Yet, some aspects of ethics change and have to be reconsidered in the light of advances in medicine and changes in law, in custom, and in society's attitudes toward its ways of life and death. Such developments are reflected in the latest revision of the American Medical Association's<i>Opinions and Reports of the Judicial Council</i>, including such topics as test-tube fertilization, fetal research, genetic engineering, euthanasia, and even the moral criteria for medical costs. At the AMA's annual meeting in July 1980, the House of Delegates received an ad hoc committee report on principles of medical ethics, even though countless aspects of ethics seem to allow no final word.
Reporting randomized controlled trials
Authors: C. D. Atkins
Journal: JAMA (1995)

<h3>In Reply.</h3> —We are glad Dr Atkins supports our experiment in structured reporting.<sup>1</sup>Atkins raises the issue of the potential difficulty in reporting randomized controlled trials using this format. Similar concerns were also raised with the development of more informative abstracts—"structured abstracts." Evidence to date indicates that structured abstracts have had a positive impact on how the results of studies are communicated.<sup>2</sup> There is also evidence that the quality of reporting of structured abstracts is better than that of nonstructured abstracts. Taddio and colleagues<sup>3</sup>compared the quality of reporting of 150 nonstructured abstracts (published in 1988 and 1989) and 150 structured abstracts (published in 1991 and 1992) published in the<i>British Medical Journal, Canadian Medical Association Journal</i>, and<i>JAMA</i>. Quality was assessed using a 32-item criteria checklist. The scoring range was between 0 and 100 with higher scores indicating superior quality. Assessors completed their quality assessment blinded
Highlights
Journal: JAMA Dermatology (2018)

Low Recurrence of LM Treated With Topical Imiquimod 885Lentigo maligna (LM) is commonly found on the head and neck in relatively older patients, where staged excision may result in significant cosmetic morbidity.Imiquimod cream, 5%, has been used off-label as monotherapy for LM and may be used before staged excision to reduce surgical margins.In this retrospective medical record review, Donigan et al determined that 81% of patients with LM had clear margins after 1 stage.Among these patients, residual LM was seen in only 18%, suggesting that 82% were free of detectable LM.These data support the use of neoadjuvant topical imiquimod cream prior to conservatively staged excision for LM.
The Diseases of Children.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tables and Notes on Human Osteology, for the Use of Students of Medicine.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Variceal pressure response to propranolol is useful in predicting the risk of variceal rebleeding L. Ruiz del Arbol, A. Monescillo, C. Lafuente, C. Arocena, JC Erdozaín. Liver Hemodynamic Unit and S. Gastroenterología. Hospital Ramón y Cajal.Madrid. Spain
Journal: Hepatology (1994)
The VEGF-C/Flt-4 Axis Promotes Invasion and Metastasis of Cancer Cells
Authors: Jen-Liang Su, Pan-Chyr Yang, Jin-Yuan Shih, Ching-Yao Yang, Lin-Hung Wei, Chang-Yao Hsieh, Chia-Hung Chou, Yung-Ming Jeng, Ming-Yang Wang, King-Jen Chang, Mien-Chie Hung, Min-Liang Kuo
Journal: Cancer Cell (2008)
Section 17.—Thrombotic Thrombocytopenic Purpura
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential processing of an organic anion transport protein (oatp) in rat liver and kidney . Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY and *Div. of Clin. Pharmacol., University Hospital, Zurich, Switzerland
Journal: Hepatology (1995)

This study investigated the transfer of T4 from cerebrospinal fluid (CSF) into the choroid plexuses (CP) and ventricular brain regions, and the role of P-glycoprotein (P-gp), multidrug resistance protein 1 (mrp1) and organic anion transporting polypeptides (oatps). During in vivo ventriculo-cisternal (V-C) perfusion in the anesthetized rabbit (meditomidine hydrochloride 0.5 mg kg− 1, pentobarbitone 10 mg kg− 1 i.v.), 125I-T4 was perfused continuously into ventricular CSF with reference molecules 14C-mannitol and blue dextran. Over 2 h, 36.9 ± 4.6% 125I-T4 was recovered in cisternal CSF. Addition of P-gp substrate verapamil increased CSF 125I-T4 recovery to 51.4 ± 2.8%, although mrp1 and oatp substrates had no significant effect. In brain, 125I-T4 showed greatest accumulation in the CP (1.52 ± 0.31 ml g− 1), followed by ventricular regions (caudate putamen, ependyma, hippocampus, 0.05–0.14 ml g− 1). At the CP, verapamil and probenecid (but not indomethacin) significantly increased 125I-T4 accumulation, implicating a role for P-gp and oatps. Of other brain regions, all three drugs increased accumulation in caudate putamen 3–5 times, and indomethacin and probenecid increased accumulation in ependyma 4–5 times. The role of P-gp was investigated further in isolated incubated CPs using 5 μg/ml C219 anti-P-gp antibody. Both 125I-T4 and 3H-cyclosporin accumulation increased by 80%, suggesting that P-gp is functional in the CP and has a role in removal of T4. Combined with the in vivo results, these studies suggest that P-gp provides a local homeostatic mechanism, maintaining CSF T4 levels. We conclude that P-gp and oatps contribute to the transfer of 125I-T4 between the CSF, CP and brain, hence regulating 125I-T4 availability in CSF.
Immunoaugmentative therapy. A primer on the perils of unproved treatments
Authors: G. A. Curt
Journal: JAMA (1986)

Immunoaugmentative therapy is an unproved cancer treatment that until recently was offered to patients by zoologist Lawrence Burton, PhD, at a facility in Freeport, Bahamas. The therapy consists of serum measurements of certain "immune deficiencies" and purportedly restores immune function by injection of products variously derived from tumor tissue and blood from individuals with cancer and healthy volunteers. Immunoaugmentative therapy represents a potentially serious public health risk, since it is capable of transmitting hepatitis B and the presumed etiologic agent for the acquired immunodeficiency syndrome. Physicians and health officials who learn of patients receiving this therapy are advised that its efficacy remains unproved and that the risk of receiving contaminated blood products is considerable. (<i>JAMA</i>1986;255:505-507)
Psychoanalytical Historical Island in Chicago (1911-1912)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats:</i>Percentage* of Adults† Aged ≥65 Years Meeting 2008 Federal Guidelines for Leisure-Time Aerobic§ and Muscle-Strengthening¶ Activities, by Age and Type of Activity — United States, 2000–2002 and 2013–2015
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

From 2000-2002 to 2013-2015, the percentage of older adults who met the 2008 federal guidelines for aerobic activity increased from 35.7% to 42.5% among persons aged 65-74 years, from 24.5% to 30.9% among persons aged 75-84 years, and from 11.9% to 19.4% among persons aged ≥85 years. The percentage who met the guidelines for muscle strengthening activities increased from 11.7% to 19.3% among those aged 65-74 years, from 9.6% to 14.6% among those aged 75-84 years, and from 6.5% to 10.4% among those aged ≥85 years. In both periods, within each age group participation declined with age and was lower for muscle strengthening activities compared with aerobic activities.
Chromatographic Modeling of the Release of Particle-Adsorbed Molecules into Synthetic Alveolar Surfactant
Authors: Shelley S. Sehnert, Terence H. Risby
Journal: Environmental Health Perspectives (1988)

Pseudophase liquid chromatography was used to measure the thermodynamic parameters governing adsorption of organic molecules from the surfaces of carbonaceous particles into liposomal zwitterionic mobile phases. These mobile phases contain many of the important physicochemical parameters of alveolar surfactant. Results show that physical desorption into model surfactant will be dependent upon the heat of solution and the heat of adsorption. Dominance of either thermodynamic parameter is dependent upon the relative polarity of the adsorbent surface and the adsorbate molecule. It is postulated from data obtained from simple molecules containing relevant organic functional groups that physical desorption of environmental agents from the surfaces of particulate complexes into alveolar surfactant may be predicted both by quantification of the polarity of the system and of the extent of surface coverage under investigation.
Depression as a risk factor for ischaemic heart disease in men: population based case-control study
Journal: BMJ (1998)

Objective: To determine the relation between depression, anxiety, and use of antidepressants and the onset of ischaemic heart disease.Design: Population based case-control study.Setting: All 5623 patients registered with one general practice.Subjects: 188 male cases with ischaemic heart disease matched by age to 485 male controls without ischaemic heart disease; 139 female cases with ischaemic heart disease matched by age to 412 female controls.Main outcome measure: Adjusted odds ratios calculated by conditional logistic regression.Results: The risk of ischaemic heart disease was three times higher among men with a recorded diagnosis of depression than among controls of the same age (odds ratio 3.09; 95% confidence interval 1.33 to 7.21; P = 0.009).This association persisted when smoking status, diabetes, hypertension, and underprivileged area (UPA(8)) score were included in a multivariate model (adjusted 2.75; 1.13 to 6.69; P = 0.03).Men with depression within the preceding 10 years were three times more likely to develop ischaemic heart disease than were the controls (3.13; 1.27 to 7.70; P = 0.01).Men with ischaemic heart disease had a higher risk of subsequent ischaemic heart disease than men without ischaemic heart disease (adjusted 2.34; 1.34 to 4.10; P = 0.003).Depression was not a risk factor for ischaemic heart disease in women on multivariate analysis (adjusted 1.34; 0.70 to 2.56; P = 0.38).Anxiety and subsequent ischaemic heart disease were not significantly associated in men or women.Conclusion: Depression may be an independent risk factor for ischaemic heart disease in men, but not in women.
Utility of circulating tumor DNA (ctDNA) versus tumor tissue clinical sequencing for enrolling patients (Pts) with advanced gastrointestinal (GI) cancer to matched clinical trials: SCRUM-Japan GI-SCREEN and GOZILA Combined Analysis.
Authors: Yoshiaki Nakamura, Hiroya Taniguchi, Hideaki Bando, Ken Kato, Taito Esaki, Yoshito Komatsu, Naoki Takahashi, Makoto Ueno, Yoshinori Kagawa, Tomohiro Nishina, Takeshi Kato, Yoshiyuki Yamamoto, Junji Furuse, Tadamichi Denda, Hisato Kawakami, Eiji Oki, Yu Sunakawa, Taroh Satoh, Takayuki Yoshino, Atsushi Ohtsu
Journal: Journal of Clinical Oncology (2020)

5 Background: Blood-based genomic profiling by ctDNA analysis has a promise to potentially identify actionable genomic alterations. However, utility of clinical sequencing with ctDNA compared with that with tumor tissue for enrolling cancer pts to matched clinical trials remains unclear. Herein we investigated the utility of ctDNA clinical sequencing by the SCRUM-Japan GI-SCREEN and GOZILA Combined Analysis. Methods: In the GI-SCREEN, tumor tissue samples of pts with advanced GI cancer were analyzed by a next generation sequencing (NGS)-based assay, Oncomine Comprehensive Assay since Feb 2015. In the GOZILA, plasma samples of pts with advanced GI cancer were analyzed by an NGS-based ctDNA assay, Guardant360 since Feb 2018. Tests were performed centrally by CLIA-certified and CAP-accredited laboratories. Pts with actionable alterations were enrolled to matched company-sponsored or investigator-initiated clinical trials. Results: As of Apr 2019, test results were generated in 5,029 out of 5,743 pts (88%) in GI-SCREEN and 1,089 out of 1,103 pts (99%) in GOZILA ( P &lt; 0.0001).Median turnaround time (TAT) was 35 days in GI-SCREEN and 12 days in GOZILA ( P &lt; 0.0001). There were no differences in other baseline characteristics between GI-SCREEN and GOZILA. Proportion of enrolling matched clinical trials in GOZILA was significantly higher than that in GI-SCREEN (126 pts [2.2%] in GI-SCREEN vs. 60 pts [5.4%] in GOZILA, P &lt; 0.0001). Median time from GI-SCREEN or GOZILA enrollment to clinical trial enrollment was 5.9 and 1.0 months (mo), respectively ( P &lt; 0.0001). The objective response rate (ORR) and progression-free survival (PFS) were not significantly different (ORR: 17.5 vs. 16.7%, P = 1.00; median PFS: 2.8 vs. 2.0 mo, P = 0.24). Conclusions: Clinical sequencing with ctDNA having the advantage of the shorter TAT enrolled more pts with advanced GI cancer to matched clinical trials than those with tumor tissue, without compromising the efficacy. Clinical trial information: UMIN000029315.
The Breast
Authors: Franklin S. Alcorn
Journal: JAMA (1970)

Since the renaissance of mammography in 1960, Dr. Witten has been actively engaged in the study and teaching of this subject. His extensive experience preeminently qualifies him for the authorship of this volume. The first chapter, on roentgenography of the breast, dwells primarily on the accuracy of mammography, with limited discussion on actual roentgenographic technique. This emphasis, with appropriate reference notations, is a refreshingly succinct yet complete statement on the uses, limitations, and accuracy of this study. The problems contributing to the errors in diagnosis of breast neoplasm are adequately discussed. In the second chapter, the roentgenographically identifiable elements to be found in the normal breast are discussed, and even more important, clearly labeled in the figures. The variations in normal roentgenographic appearance are clearly indicated, as are the variations in the density with age, menstrual status, and pregnancy. Most of the errors in diagnosis occur in the dense breast.
THE DEADLINESS OF THE HARMLESS.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report
Authors: Cezmi A. Akdis, Mübeccel Akdis, Thomas Bieber, Carsten Bindslev-Jensen, Mark Boguniewicz, Philippe Eigenmann, Qutayba Hamid, Alexander Kapp, Donald Y.M. Leung, Jasna Lipozencic, Thomas A. Luger, Antonella Muraro, Natalija Novak, Thomas A.E. Platts-Mills, Lanny Rosenwasser, Annika Scheynius, F. Estelle R. Simons, Jonathan Spergel, Kristiina Turjanmaa, Ulrich Wahn, Stefan Weidinger, Thomas Werfel, Torsten Zuberbier
Journal: Journal of Allergy and Clinical Immunology (2006)
Update: Serologic Testing for HIV-1 Antibody—United States, 1988 and 1989
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intraleukocytic bacteria in endocarditis patients
Authors: D. L. Powers
Journal: JAMA (1974)

Leukocyte monolayers from the peripheral blood of 16 patients suspected of having infective endocarditis and six normal control subjects were examined microscopically. No intraleukocytic bacteria were observed in preparations from the six normal controls. Six of the 16 endocarditis suspects had sterile blood cultures and the diagnosis was discarded. All six patients had negative monolayer preparations. Intraleukocytic bacteria were found in six of the ten patients with a final clinical diagnosis of endocarditis. Nine of these patients also had positive blood cultures. A leukocyte monolayer preparation from the one endocarditis patient with negative blood cultures contained intracellular cocci, and the patient responded to antibiotic therapy.