tbuckley/cabot-search huggingface dataset:
A crucial role for thiol antioxidants in estrogen-deficiency bone loss
Authors: Jenny M. Lean, Julie T. Davies, Karen Fuller, Christopher J. Jagger, Barrie Kirstein, Geoffrey A. Partington, Zoë L. Urry, Timothy J. Chambers
Journal: Journal of Clinical Investigation (2003)

The mechanisms through which estrogen prevents bone loss are uncertain. Elsewhere, estrogen exerts beneficial actions by suppression of reactive oxygen species (ROS). ROS stimulate osteoclasts, the cells that resorb bone. Thus, estrogen might prevent bone loss by enhancing oxidant defenses in bone. We found that glutathione and thioredoxin, the major thiol antioxidants, and glutathione and thioredoxin reductases, the enzymes responsible for maintaining them in a reduced state, fell substantially in rodent bone marrow after ovariectomy and were rapidly normalized by exogenous 17-β estradiol. Moreover, administration of N-acetyl cysteine (NAC) or ascorbate, antioxidants that increase tissue glutathione levels, abolished ovariectomy-induced bone loss, while L-buthionine-(S,R)-sulphoximine (BSO), a specific inhibitor of glutathione synthesis, caused substantial bone loss. The 17-β estradiol increased glutathione and glutathione and thioredoxin reductases in osteoclast-like cells in vitro. Furthermore, in vitro NAC prevented osteoclast formation and NF-κB activation. BSO and hydrogen peroxide did the opposite. Expression of TNF-α, a target for NF-κB and a cytokine strongly implicated in estrogen-deficiency bone loss, was suppressed in osteoclasts by 17-β estradiol and NAC. These observations strongly suggest that estrogen deficiency causes bone loss by lowering thiol antioxidants in osteoclasts. This directly sensitizes osteoclasts to osteoclastogenic signals and entrains ROS-enhanced expression of cytokines that promote osteoclastic bone resorption.
Proposed Changes in Format for Presentation of Notifiable Disease Report Data
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Goulstonian Lectures on Puerperal Fever
Authors: R. J. Lee
Journal: BMJ (1875)

37'the year I864, I exhibited one of these cases at the Pathological So- ciety, as a case of bronzed skin disease simulating the discoloration of Addison's disease.Such cases, however, though they undoubtedly pre- sent some appearances of Addison's disease, may be easily distinguished from it.In my patient, a woman, aged 65, the skin was extensively bronzed, especially over the abdomen, chest, and back; but the dis- coloration, wheni carefully examined, was totally different from the bronzing of Addison's disease.It was seated in the superficial instead of in the deeper layers of the epidermis.It was paler instead of deeper in the face, handls, and other parts, which are naturally the seats of most pigment.These small, isolated, dark spots were all on the pale instead of on the discolored parts of the skin.Moreover, the dark- ened cuticle was not soft and smooth, but in many parts raised and rough.Such constitutional symptoms as were present-debility, languor, and a sense of sinking at the epigastrium-were referable to apparent causes, and were soon removed by tonic treatment, and an ample sup- ply of food.I should add that, by the use of alkaline warm baths and soap, the discoloration was greatly diminished, though the skin did not regain its normal hue.Again, it is well known that pityriasis versicolor is attended by discolorations of the skin, and cases of this kind have been adduced to disprove the connection between bronzed skin and disease of the suprarenal capsules; but the nature and the distribution of these dis- colorations, as well as their modes of development and disappearance, are widely different from the two characters of the discoloration of skin in Addison's disease.The dark patches are more upon the trunk and limbs than upon the face.They have abrupt margins and convex borders, and are interspersed with spaces of normal coloured skin; they appear and disappear rapidly: and no asthenia or other constitutional symptoms are associated with them.
Incorrect Table Footnotes
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphocytic Choriomeningitis Virus Infection in Organ Transplant Recipients--Massachusetts, Rhode Island, 2005
Journal: JAMA (2005)

On May 3, 2005, CDC received a report of severe illness in four patients who had received solid organ transplants from a common donor. All four organ recipients subsequently were found to have evidence of infection with lymphocytic choriomeningitis virus (LCMV), a rodent-borne Old World arenavirus. Preliminary findings from the ensuing investigation indicate the source of infection likely was an infected hamster in the donor's home. This report summarizes the ongoing investigation and provides information on exposure risks and possible prevention measures.
BUENOS AIRES
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cover
Authors: Laura King
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experiences of rosacea and its treatment: an interpretative phenomenological analysis
Authors: S.A. Johnston, M. Krasuska, A. Millings, A.C. Lavda, A.R. Thompson
Journal: British Journal of Dermatology (2018)

Rosacea is a skin disorder which causes flushing and redness of the face. Relatively few people with rosacea receive specialist dermatology treatment or psychological support. Despite this, individuals with rosacea can experience social anxiety, depression and embarrassment, and decreased quality of life. Whilst questionnaire based studies have been used to investigate the type of distress that people living with rosacea might experience, there are no studies that have sought to gain an in‐depth understanding of the experiences of living with this visible skin condition. Therefore, this study used face‐to‐face interviews to learn about participants' complex, individual experience of life with rosacea. A qualitative approach called interpretative phenomenological analysis (IPA) was used to guide the interviews and analysis. This approach to research focuses on individual accounts and has been extensively used to investigate illness experience. In this study nine participants took part in detailed semi‐structured interviews. Three overarching themes were gleamed from these interviews; self‐consciousness, which focused on the fear of others assigning blame to participants for having caused their own symptoms; avoidance, concealment, and hiding emotions, referring to the coping strategies participants employed in response to rosacea; and inconsistencies in treatment, which focused on the need for medical professionals to assess the emotional wellbeing of patients with rosacea. The findings are consistent with qualitative findings from patients with other skin conditions that demonstrate that self‐conscious emotions can be a significant part of the experience of life with a skin condition. Healthcare professionals need to take care to assess for the presence of such concerns in rosacea, and where unhelpful thoughts or beliefs are reported, patients may benefit from dermatology specific psychological support.
Myocardial metabolism in children having open-heart surgery
Authors: E. A. Moffitt
Journal: JAMA (1970)

The electrolyte and metabolic responses to operation and whole-body perfusion for correction of congenital cardiac defects were studied in nine children. Whole-body metabolism was not different between cyanotic and noncyanotic patients, but in the cyanotic group the myocardium tolerated periods of aortic clamping with less anaerobic glycolysis as compared to considerable lactate production during perfusion and anoxic asystole in the noncyanotic group. More severe ketosis developed postoperatively in children than in adults. The increase in serum insulin from the glucose load of the priming solution was greater in children than in adults. Lipid was metabolized predominantly by the body for energy in spite of adequate glucose available, as seen in starvation and stress. Nonesterified fatty acids continued to be the major myocardial energy-producing substrate, although lactate, ketone bodies, and pyruvate were also extracted.
O10.01 * PROGNOSTIC AND PREDICTIVE BIOMARKER-BASED SUBGROUPS IN THE NOA-04 TRIAL
Authors: W. Wick, D. Capper, M. Sill, V. Hovestadt, S. M. Pfister, M. Platten, G. Reifenberger, A. von Deimling, M. Weller, B. Wiestler
Journal: Neuro-Oncology (2014)

BACKGROUND: Molecular biomarkers, including isocitrate dehydrogenase 1 or 2 (IDH1/2) mutation, 1p/19q codeletion, mutations and (consequently) loss of expression of alpha-thalassemia/mental retardation syndrome X-linked (ATRX) and O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation, improve prognostication and may even guide treatment decisions in patients with anaplastic gliomas. Illumina Infinium HumanMethylation450 BeadChip arrays (HM450) allow the determination of large-scale methylation profiles and genome-wide DNA copy number changes, enabling molecular subgrouping of tumors. In addition, algorithms have been developed to detect the glioma CpG island methylator phenotype (G-CIMP) associated with IDH1/2 mutation, 1p/19q codeletion and MGMT promoter methylation using this assay. METHODS: In the biomarker cohort of the NOA-04 trial, the diagnostic and prognostic performance of these molecular markers using single tests, HM450 data and HM450-based algorithms has been investigated to propose biological subgroups, which reflect outcomes and potentially influence treatment decisions. RESULTS: Loss of ATRX expression was detected in 45% of anaplastic astrocytomas (AA), 27% of anaplastic oligoastrocytomas (AOA) and 10% of anaplastic oligodendrogliomas (AO). It was mostly restricted to IDH mutant tumors and almost mutually exclusive with 1p/19q co-deletion. In tumors with IDH1 mutation, MGMT promoter methylation was associated with prolonged progression-free survival (PFS) with chemotherapy or radiotherapy (RT), and thus prognostic. In tumors without IDH1 mutation, MGMT promoter methylation was associated with increased PFS in patients treated with chemotherapy, too, but not in those who received RT alone as the first-line treatment, and is thus chemotherapy-predictive. Comparisons of single assays and HM450-based algorithms revealed a high concordance for IDH and 1p/19q status. The HM450-derived MGMT-STP27 model to calculate MGMT promoter methylation probability revealed this aberration in a significantly higher fraction of cases as conventional methylation-specific PCR, with 87/91 G-CIMP-positive tumors predicted as MGMT promoter-methylated. CONCLUSIONS: ATRX loss is a hallmark and favorable prognosticator of astrocytic tumors allowing a better definition of the clinically and morphologically mixed group of AOA. MGMT promoter methylation is a predictive biomarker for benefit from alkylating agent chemotherapy in patients with IDH1-wildtype, but not IDH1-mutant malignant gliomas of WHO grades III/IV. Combined IDH1/ MGMT assessment may help to individualize clinical decision making in neurooncology. G-CIMP and 1p/19q codeletion are reliably detectable by HM450 analysis and associated with prognosis in the NOA-04 trial. HM450 arrays allowed clustering of anaplastic gliomas into relevant subgroups.
169P First-line FOLFOX-4 6 cetuximab in patients with RAS wild- type metastatic colorectal cancer: The open-label, randomized, phase 3 TAILOR trial
Authors: S. Qin, J. Xu, L. Wang, Y. Cheng, T. Liu, J. Chen, J. Liu, J. Li
Journal: Annals of Oncology (2016)
Cholesterol in the elderly. Is it important?
Authors: S. B. Hulley
Journal: JAMA (1994)

There is a growing tendency to encourage measurement of and treatment for high blood cholesterol levels in elderly people. The 1993 adult treatment guidelines from the National Cholesterol Education Program (NCEP) note an "enhanced recognition [since 1988] that... high-risk elderly patients who are otherwise in good health are candidates for cholesterol-lowering therapy."<sup>1</sup>This policy shift is based on the belief that the association between blood cholesterol and coronary heart disease (CHD) persists after age 65 years and on a growing willingness to extrapolate to older people the reduced CHD rates observed in clinical trials of hypolipidemic treatment in middle-aged men. See also p 1335. In this issue ofThe Journal, the contention that an association between cholesterol and CHD persists in the elderly is called into question in a report by Krumholz et al.<sup>2</sup>The report finds no association between blood cholesterol level and CHD incidence or death
Massive Atelectasis
Journal: Annals of Internal Medicine (1929)

Article1 April 1929Massive AtelectasisC. H. COCKE, M.D., F.A.C.P.C. H. COCKE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-10-1054 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe subject for discussion this afternoon is a very brief resumé of so-called massive collapse of the lungs with the addition of case reports of two interesting unpublished cases."Massive Collapse" was first described by the Englishman, W. Pasteur, in the year 1890 after study of 7 autopsy cases which presented post diphtheritic paralysis of the diaphragm, the result of nasal and pharyngeal diphtheria. It was not observed in laryngeal cases. The same author twenty years later, in 1910, described "post operative massive collapse" in a study of 2,000 operations in which there was an incidence of 201 post operative... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Asheville, North Carolina*Attending physician Asheville Mission Hospital, Biltmore Hospital, etc. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byÜber die Atelektase 1 April 1929Volume 2, Issue 10Page: 1054-1062KeywordsAutopsyDiphtheriaLungsParalysis ePublished: 1 December 2008 Issue Published: 1 April 1929 PDF downloadLoading ...
Evaluation of a new antituberculous agent. Rifampin (Rifadin, Rimactane)
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Table of Contents
Authors: O Pagani, E Senkus, W Wood, M Colleoni, T Cufer, S Kyriakides, A Costa, E Winer, F Cardoso, J Subramanian, R Simon, J Study, R Bernstein, M Haile, J Stovall, R Boice, B Shore, D Langholz, L Thomas, C Bernstein, J Lynch, K Olsen, L Malone, A.-L Mellemkjaer, B Borresen-Dale, S Rosenstein, A Teraoka, S Diep, M Smith, A Capanu, X Reiner, R Liang, P Gatti
Journal: JNCI Journal of the National Cancer Institute (2010)
The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells
Authors: Barbara Varnum-Finney, Louise E. Purton, Monica Yu, Carolyn Brashem-Stein, David Flowers, Steven Staats, Kateri A. Moore, Isabelle Le Roux, Robert Mann, Grace Gray, Spyros Artavanis-Tsakonas, Irwin D. Bernstein
Journal: Blood (1998)
The mechanisms of aortic valve opening and closure Emmanuel Lansac, Hou Sen Lim, Yu Shomura, Nolan T. Rice, Khee Hiang Lim, Joon Hock Yeo, Christophe Acar, James H. Oury, Carlos M. G. Duran. International Heart Institute Of Montana Foundation, Missoula, MT
Journal: Journal of the American College of Cardiology (2001)
Personalized medicine in a phase I clinical trials program: The M. D. Anderson Cancer Center Initiative.
Authors: A. M. Tsimberidou, N. G. Iskander, D. S. Hong, J. J. Wheler, S. Fu, S. A. Piha-Paul, A. Naing, G. S. Falchook, F. Janku, R. Luthra, S. Wen, R. Kurzrock
Journal: Journal of Clinical Oncology (2011)

CRA2500 The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed onsite at the Meeting on June 4, 2011, and as a supplement to the June 20, 2011, issue of Journal of Clinical Oncology.
THE NEW YORK STATE MEDICAL ASSOCIATION.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal