tbuckley/cabot-search huggingface dataset:
Abstract 3572: SNPs in lncRNA genes are associated with non small cell lung cancer in a Chinese population
Authors: Ruoyang Wang, Biyun Qian
Journal: Cancer Research (2019)

Abstract Background: Recent genetic studies indicate that single nucleotide polymorphisms (SNPs) in the genes encoding non-coding RNAs are associated with lung cancer susceptibility. But the comprehensive analysis of SNPs in long non-coding RNA (lncRNA) genes has not been elucidated. Methods: Based on the previous expression microarray of lncRNAs, we genotyped 17 SNPs located in 13 selected lncRNA genes by the TaqMan method in 1294 non-small cell lung cancer (NSCLC) cases and 1729 controls. Then we followed up NSCLC patients to get the survival data, and conduct logistic regression, Kaplan-Meier method and Cox hazards regression analysis to explore the associations of SNPs with NSCLC risk and overall survival (OS). Results: We identified 4 SNPs significantly associated with NSCLC risk. For rs498238, compared with CC genotype, TT genotype could decrease the risk of NSCLC (adjusted OR=0.32, 95%CI=0.11-0.92, p=0.034). As for rs16901995, TT genotype showed significantly protective effect compared with CC genotype (adjusted OR=0.76, 95%CI=0.59-0.99, p=0.040). For rs219741 dominant model, increased risk of NSCLC was evident in younger patients (age &amp;lt;60) compared those with wild type (adjusted OR=1.47, 95%CI=1.03-2.10, p=0.033). Rs3113503 demonstrated a controversial effect on NSCLC risk. No SNPs showed effects on overall survival of NSCL patients. Conclusion: Our findings indicated that genetic variants within lncRNA genes may predict NSCLC risk in Chinese population. Citation Format: Ruoyang Wang, Biyun Qian. SNPs in lncRNA genes are associated with non small cell lung cancer in a Chinese population [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3572.
Miscellanea Medica
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
"Our Journal."
Authors: Lewis N. Davis
Journal: JAMA (1896)

Farmland, Ind., March 10, 1896. <h3>To the Editor:</h3> —Like the "general practitioner" of medicine in a backwoods district, I presume the editor of a medical journal at his desk, is not burdened with compliments of his success, but I wish to say to you that I appreciate the ability with which "ourJournal" is conducted, and the advanced views and literary skill of its editorials. Very respectfully, New York, March 24, 1896. ... By the way, the issue of March 21, which I have just received, is the best for a long time. The topography is beautiful, the make-up admirable, the cuts clean, the contents interesting. Well done, thou g. and f. s. Yours truly,
THE CLINICAL SIGNIFICANCE OF ALBUMOSURIA.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Benjamin Franklin: Physicus et Medicus
Authors: N. J. Andreasen
Journal: JAMA (1976)

Perhaps the most familiar image we have of Franklin is that of young Ben sauntering down the cobbled streets of Philadelphia, carrying two puffy rolls purchased with his last shilling. Perhaps as familiar is Franklin the inventor and scientist, who designed the Franklin stove and proved that lightning consists of electricity. Or perhaps we might think of Franklin the writer, author of Poor Richard's moralistic epigrams and the charming bagatelles composed for the sophisticated coteries of France. And then there is Franklin the diplomat abroad, persuading the English Parliament to repeal the Stamp Act; and later Vergennes to give the American rebels financial support. Or Franklin the American statesman, announcing at the Continental Congress that "we must all hang together or assuredly we will all hang separately." Or Franklin the Philadelphia philanthropist, founder of the Junto, the first volunteer fire department, the first circulating library, and a voluntary militia for local self-defense against Indian attacks. Or even Franklin the lusty founding father, father and grandfather and greatgrandfather of illegitimate sons, proposing marriage to Madame Helvetius and courting Madame Brillon simultaneously when in his 70s.
Hospital Copayments
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EDUCATIONAL TOURS FOR MEDICAL MEN.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PRELIMINARY PROGRAM OF SECTION ON OBSTETRICS AND DISEASES OF WOMEN.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fighting On
Authors: Jeffrey M. Drazen, Nihar R. Desai, Philip Green
Journal: New England Journal of Medicine (2009)

She had been living with multiple myeloma for more than 7 years before she showed up in our intensive care unit (ICU). It had not been easy, but she had beaten the median survival time by a factor of two or more. Now, late in the game, the myeloma was winning, and the options for this 83-year-old woman were dwindling. Seven months earlier, she had undergone cervical spinal fusion and the placement of rods for instability. Things had not gone well postoperatively, and she had developed renal failure, most likely from the triple hit of her myeloma, wound sepsis, and . . .
Obstetrical Endocrinology
Authors: Robert B. Greenblatt
Journal: JAMA (1962)

Obstetrical Endocrinology is a small monograph comprised of a series of guest lectures presented at the University of Bahia, Brazil. It is a short, concise work based on recent experiments and it highlights the subject of obstetrical endocrinology with a considerable amount of opinion and an equal amount of speculation. The experiments of the author and his colleagues make up a large portion of the monograph. The book is well written, the style is simple and clear, and the format is excellent. The book has much to commend it. There is a wealth of useful information to be found in its pages. Unfortunately, there is also a certain amount of misinformation. Frequently the author fails to discriminate between fact and theory. This criticism should not in any way detract from the value of this excellent monograph. The first and fourth chapters are primarily concerned with the etiology of abortion, revolving
Distal Antrectomy With Vagectomy for Duodenal Ulcer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Students challenged to make ethics part of their 'habit of thought'
Authors: T. Randall
Journal: JAMA (1992)

FOR 100 YEARS, Creighton University School of Medicine, has had to deal with a challenge to which the majority of medical schools haven't had to devote one moment of thought: how to remain faithful to the specific religious tradition upon which the school was founded and at the same time prepare students-from a variety of religious and nonreligious perspectives—for a secular world. One of the most distinguishing characteristics of this medical school is that, as one of only four Jesuit medical schools in the country, it continuously seeks to define its Roman Catholic identity and the way this is manifested in contemporary medical education. Perhaps one of the most evident manifestations is Creighton's heavy emphasis on medical ethics, in both teaching and research. Creighton's Center for Health Policy and Research has seven faculty members, a remarkably large program for a school of this size. The faculty comes from a broad
All gender inequality is not equal
Authors: None The Lancet Global Health
Journal: The Lancet Global Health (2018)

No one could have failed to notice the rise of women in the collective consciousness over the past year: their under-representation at the highest levels in the workplace, their discrimination in terms of pay, and their ongoing subjection to power-related assaults in the form of physical, psychological, and sexual violence and harassment. The #MeToo movement has perhaps captured the lion's share of recent attention, triggered by revelations from women who were themselves viewed as being in positions of power.
Diagnostic Differentiation Between Esophageal Dilatation and Sliding Hiatal Hernia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DYSPEPTIC ASTHMA.
Authors: MAX EINHORN
Journal: JAMA (1902)

Asthma due to digestive disturbances was first described by Henoch<sup>1</sup>under the name of asthma dyspepticum. The original communication of this clinician referred to the occurrence of the condition during acute digestive disturbances in children. His cases all ran under alarming symptoms—the dyspnea being of a high degree and attended with cyanosis and cold extremities —and failed to improve under the ordinary stimulants, but entirely recovered after a treatment directed against the disturbances of the digestive tract. In his paper Henoch accepts Traube's explanation for the dyspeptic origin of asthma, which is as follows: "The gastric irritation causes reflexly a vasomotor contraction of the small arteries, which explains the cold extremities, the imperceptible pulse, the congestion in the venous system and in the right heart, cyanosis, accumulation of carbon dioxid in the blood and as a consequence thereof the frequent dyspneic respiration." A short while afterwards Silbermann<sup>2</sup>described
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
Authors: Claus Cursiefen, Lu Chen, Leonardo P. Borges, David Jackson, Jingtai Cao, Czeslaw Radziejewski, Patricia A. D’Amore, M. Reza Dana, Stanley J. Wiegand, J. Wayne Streilein
Journal: Journal of Clinical Investigation (2004)

Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF-C and -D on VEGFR3. In contrast, VEGF-A binds VEGFR1 and VEGFR2 and is an essential hemangiogenic factor. We re-evaluated the potential role of VEGF-A in lymphangiogenesis using a novel model in which both lymphangiogenesis and hemangiogenesis are induced in the normally avascular cornea. Administration of VEGF Trap, a receptor-based fusion protein that binds and neutralizes VEGF-A but not VEGF-C or -D, completely inhibited both hemangiogenesis and the outgrowth of LYVE-1+ lymphatic vessels following injury. Furthermore, both lymphangiogenesis and hemangiogenesis were significantly reduced in mice transgenic for VEGF-A164/164 or VEGF-A188/188 (each of which expresses only one of the three principle VEGF-A isoforms). Because VEGF-A is chemotactic for macrophages and we demonstrate here that macrophages in inflamed corneas release lymphangiogenic VEGF-C/VEGF-D, we evaluated the possibility that macrophage recruitment plays a role in VEGF-A–mediated lymphangiogenesis. Either systemic depletion of all bone marrow–derived cells (by irradiation) or local depletion of macrophages in the cornea (using clodronate liposomes) prior to injury significantly inhibited both hemangiogenesis and lymphangiogenesis. We conclude that VEGF-A recruitment of monocytes/macrophages plays a crucial role in inducing inflammatory neovascularization by supplying/amplifying signals essential for pathological hemangiogenesis and lymphangiogenesis.
News from the American Heart Association
Authors: Steven Herlitz, Lloyd Hefner, Harold Sandier, Mrs Mary, Ann King, Mrs Pontious, Rich- Ard Varco, ; Kittle, Ray Gifford, Fletcher Mcdowell, Walter Pritchard, Eu- Gene Braunwald, San Diego
Journal: Circulation Research (1971)

If Your Child Has a Congenital Heart Defect" has been published for use by parents of children with operable defects, by organizations for crippled children and by rehabilitation services.The booklet is intended to prepare parents for events that may follow the preliminary diagnosis.These include further diagnostic tests, hospitalization, surgery, convalescence, and the transition to normal living.The importance of careful procedures and planning are stressed and parents are alerted to some of the problems that may arise before and beyond surgery.Featured in the new booklet are sections on surgery for congenital defects, information on state services for crippled children's services, vocational rehabilitation programs and visiting nurse services, and heart diagrams to enable physicians to illustrate a child's particular defect.
Effect of Size of Man-Made and Natural Mineral Fibers on Chemiluminescent Response in Human Monocyte-Derived Macrophages
Authors: Masayuki Ohyama, Toru Otake, Kenji Morinaga
Journal: Environmental Health Perspectives (2001)

Fiber size is an important factor in the tumorigenicity of various mineral fibers and asbestos fibers in animal experiments. We examined the time course of the ability to induce lucigenin-dependent chemiluminescence (CL) from human monocyte-derived macrophages exposed to Japan Fibrous Material standard reference samples (glass wool, rock wool, micro glass fiber, two types of refractory ceramic fiber, refractory mullite fiber, potassium titanium whisker, silicon carbide whisker, titanium oxide whisker, and wollastonite). We determined how fiber length or width might modify the response of cells. We found that the patterns of time-dependent increase of CL (sigmoid type) were similar for each sample except wollastonite. We observed a strong correlation between geometric-mean length and ability to induce CL in seven samples > 6 microm in length over the time course (largest r(2) = 0.9760). Although we also observed a close positive correlation between geometric-mean width and the ability to induce CL in eight samples < 1.8 microm in width at 15 min (r(2) = 0.8760), a sample of 2.4 microm in width had a low ability to induce CL. Moreover, the relationship between width and the rate of increase in ability to induce CL had a negative correlation at 30-60 min (largest r(2) = 0.7473). Our findings suggest that the release of superoxide from macrophages occurs nonspecifically for various types of mineral fibers depending on fiber length.
Putrid Empyema
Authors: John W. Strieder, Joseph P. Lynch
Journal: New England Journal of Medicine (1946)

PUTRID empyema has been recognized as a clinical entity for many years and has recently been the subject of a number of excellent reports.1 2 3 4 Nevertheless, many surgeons fail to distinguish it from ordinary pyogenic empyema and, persisting in this misapprehension, treat it as they ordinarily treat this relatively benign lesion, with disastrous results. It is our belief that with a better understanding of the nature of the disease recognition will be prompter, treatment will be more adequate, and the mortality, which has been high, will be lowered.The report that follows is based on an analysis of patients on the . . .
Msspelling.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal