tbuckley/cabot-search huggingface dataset:
INFECTION IN CHILDREN.
Journal: JAMA (1904)

Very few people seem to realize how much more dangerous, as regards possible infection, is the usual position of the child in the house than that of any other member of the family. The little one creeps about the floor getting its hands soiled with the accumulation of material that has been carried in from the street, unable to protect itself by reason or experience, and consequently likely to handle all sorts of offensive material if any opportunity should arise; and beside living for many hours in the day so close to the floor that every little eddy of air, every little draft that blows from open doors or windows, and every movement of any kind in the room causes the lifting of dust which is usually carried only just high enough to be inhaled by the child or to cover its clothing and thence be removed by its active
Operation Venus
Authors: Joseph A. Chiappa
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Since venereal diseases (VD) have reached epidemic proportions in the United States, a national organization has taken on the task of directing victims to treatment. Operation Venus, a national hotline, provides information on treatment centers, clinics, and physicians to callers from all over continental United States. The problem is that there are approximately 2,000 counties in the United States that have no treatment centers and no physicians to whom suspected victims can be referred. Operation Venus is looking for physicians who will provide tests and treatment to persons with VD at nominal fees or on a sliding scale. Physicians who would like to be a part of the Operation Venus program by receiving referrals may contact us by calling our toll-free number or by writing to the Director, Operation Venus, 1213 Clover St, Philadelphia, PA 19107. Physicians involved with the Operation Venus program receive periodic up-to-date information
Rethinking medicine
Authors: Martin Marshall, Jocelyn Cornwell, Alf Collins
Journal: BMJ (2018)

Modern medicine is one of humanity's great achievements.It improves, prolongs, and saves lives by applying the biomedical and clinical sciences to the diagnosis and treatment of disease.Its strength lies in its clarity and focus, making it an easy model to explain, understand, and put into practice.People have found it powerful, beguiling, seductive even.It is not surprising that the medical model is proving so popular: it serves society well.But there's something going on out there.Increasing numbers of doctors and patients are questioning whether medicine has overstretched itself, 1 whether it is always as effective as proponents claim, and whether there are instances when the side effects and unintended consequences outweigh the benefits.This critique is not new, 2 3 but it has recently found a common voice in initiatives that transcend health systems and national borders, such as minimally disruptive medicine, 4 high integrity care, 5 and rethink health.
The surveillance of infectious diseases
Authors: S. B. Thacker
Journal: JAMA (1983)

Surveillance is the collection, collation, and analysis of data and the dissemination to those who need to know so that an action can result. This article describes the clinician's critical role in disease reporting and outlines the benefits of surveillance to clinical practice. Four commonly used systems of disease surveillance are notifiable disease reporting, laboratory-based surveillance, hospital-based surveillance, and population-based surveillance. We analyze the relative strengths and limitations of each of these systems and present current efforts to evaluate and improve surveillance activities. (<i>JAMA</i>1983;249:1181-1185)
Flint's Practice of Medicine.
Journal: JAMA (1894)

Flint's Practice of Medicine.1-?This excellent treatise on medicine has acquired for itself in the United States a reputation similar to that enjoyed in England by the admirable lectures on physic by Sir T. Watson.It may not possess the same charm of.style, but it has like solidity, the fruit of long and patient observation, and presents kindred moderation and eclecticism.We have referred to many of the most important chapters and find that the revision spoken of in the preface is a genuine one, and that the author has very fairly brought up his matter to the level of the knowledge of the present day.Dr. Mint is no believer in the doctrine of change of type in dis- eases, and has steadfastly upheld the value of bloodletting in some acute inflammations, as, for example, in pleuritis and pneumonia, or, as he prefers to call it, " pneumonitis."Looking to his instructions
INSTRUCTION IN PSYCHIATRY.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Internal Medicine (2019)

Association of Opioids With Increased Pneumonia Risk 297In this nested case-control study, Edelman and colleagues assessed the association of prescribed opioids with the risk for community-acquired pneumonia requiring hospitalization among patients with and without HIV in the Veterans Aging Cohort Study.Patients with community-acquired pneumonia requiring hospitalization were matched 1:5 with control individuals without community-acquired pneumonia by age, sex, race/ethnicity, length of observation, and HIV status.Results showed that prescribed opioids, especially higher-dose and immunosuppressive opioids, were associated with increased community-acquired pneumonia risk among persons with and without HIV. SHARING MEDICINE Care for Patients Who Forgo Maintenance Dialysis 305Wong and colleagues performed this qualitative analysis using documentation in the electronic medical records of adult patients with advanced kidney disease receiving care from the US Veterans Health Administration to describe how decisions not to start dialysis unfold in the clinical setting.During analysis, 3 prominent themes emerged: (1) clinicians did not readily accept patients' wishes not to start dialysis, (2) clinicians decided particular patients were not candidates for dialysis seemingly without consideration of the patients' goals and values, and (3) clinicians seemed to believe they had little more to offer patients who would not be starting dialysis.Ladin and Smith provide the Invited Commentary. Invited Commentary 313 Treatment and Outcomes After Asthma Exacerbation 333In this retrospective cohort study, Stefan and colleagues assessed outcomes associated with the addition of antibiotic treatment in patients hospitalized for asthma exacerbation and treated with corticosteroids who had no other indication for antibiotic therapy.The primary outcome measure was hospital length of stay, and other measures were treatment failure within 30 days of discharge, hospital costs, and antibiotic-related diarrhea.Results showed that compared with patients who were not treated with antibiotics, treated patients had a significantly longer hospital stay, similar rate of treatment failure, and higher risk of antibiotic-related diarrhea.
Prosthetic valve endocarditis caused by Histoplasma capsulatum
Authors: W. J. Alexander
Journal: JAMA (1979)

HISTOPLASMA<i>capsulatum</i>is a rare cause of infective endocarditis. Three patients have previously been described with postoperative histoplasma endocarditis.<sup>1-3</sup>We describe here a patient with prosthetic valve endocarditis (PVE) and chronic meningitis caused by<i>H capsulatum</i>. This organism should be considered in the evaluation of patients with intracardiac prostheses, fever, and negative blood cultures. <h3>Report of a Case</h3> In January 1972, a 37-year-old man had a stenotic aortic valve replaced by a homograft. In September 1975, he noted dyspnea on exertion, and aortic regurgitation was detected. Diuretics and digitalis were prescribed, but heart failure worsened. On March 23, 1976, the defective homograft was replaced at our hospital by a Bjork-Shiley aortic prosthesis. The excised hemograft showed only fibrosis and calcification. The patient did well until July 1976, when fever and weight loss were noted, followed by right hemiparesis and aphasia. He was admitted to another hospital, where CSF was
Analysis of myocardial sympathetic innervation in patients with cardiac amyloidosis using I-123 MIBG imaging Minoru Hongo, Hiroki Kasai, Kazuhisa Urushibata, Hiroshi Imamura, Mafumi Owa, Ta-ige Fujii, Keishi Kubo. Shinshu University School of Medicine, Matsumoto, Japan
Journal: Journal of the American College of Cardiology (2001)
The acquired immune deficiency syndrome. The ever-broadening clinical spectrum
Authors: A. S. Fauci
Journal: JAMA (1983)

The acquired immune deficiency syndrome (AIDS) is characterized by a severe and apparently irreversible acquired defect in cell-mediated immunity that predisposes the host to severe opportunistic infections and/or unusual neoplasms such as Kaposi's sarcoma.<sup>1</sup>It has attracted an extraordinary amount of attention, interest, and concern in the medical community as well as among the general public. Indeed, the concern is justified, since we are witnessing at the present time the evolution of a new disease process of unknown etiology with a mortality of at least 50% and possibly as high as 75% to 100% and with a doubling of the number of patients afflicted every six months. The disease was first believed to be confined to a particular epidemiologically defined segment of the population, ie, male homosexuals.<sup>2,3</sup>Earlier hypotheses suggested that there was something within the life-style of male homosexuals that predisposed them to this syndrome. Various theories
ACTR-31. THE USE OF TTFIELDS FOR NEWLY DIAGNOSED GBM PATIENTS IN GERMANY IN ROUTINE CLINICAL CARE (TIGER: TTFIELDS IN GERMANY IN ROUTINE CLINICAL CARE)
Authors: Oliver Bähr, Ghazaleh Tabatabai, Rainer Fietkau, Roland Goldbrunner, Martin Glas
Journal: Neuro-Oncology (2019)

Abstract OBJECTIVE Survival for the most common brain tumor, glioblastoma (GBM), has not improved since 2005, despite numerous phase 3 trials. The phase 3 EF-14 trial demonstrated significantly improved overall, progression-free and long-term survival in newly diagnosed GBM (ndGBM) patients by addition of TTFields to adjuvant temozolomide chemotherapy. As there is very high interest among prescribing physicians from all disciplines to further evaluate these effects in routine clinical care, the aim of the TIGER study is to assess safety and efficacy of TTFields in routine care and reasons for patients refusing TTFields treatment, quality of life, treatment duration and compliance. METHODS The TIGER study is a multi-centre, prospective, non-interventional study in Germany (NCT03258021). All ndGBM patients who are eligible for TTFields therapy are asked for consent for study-participation and comprehensively introduced to the therapy to allow them to make a conscious positive or negative therapy decision. At baseline and 2–4 months after treatment start, demographic data, the QoL and reasons for therapy decision are evaluated utilizing the EORTC-QLQ-C30/BN-20 and TTFields questionnaire. Inclusion of 1000 patients is planned (500 with positive/negative treatment decision, respectively) with a follow-up period of 18 months. RESULTS At the last data cut-off (May 2019), 497 patients have made a decision regarding treatment with TTFields. Within this population, 84% of patients decided to undergo TTFields therapy. The median age of patients included in the trial is currently 58.3 years (19–85). 91% of patients report that the prospect of treatment success considerably or strongly affects treatment decision. Most recent data will be presented at the meeting. CONCLUSION Systematic and prospective data assessment for using TTFields in routine clinical care including patient’s therapy decision can be evaluated in TIGER. Additionally, the study supports the analysis of treatment duration and usage rate, which could drive future assessment of TTFields treatment duration.
<i>Status Epilepticus.</i>By G. H. Trowbridge, A. M., M. D., and C. M. Mayberry, A. M., M. D., Fellows of the American Academy of Medicine; Assistant Physicians State Hospital for the Insane, Danville, Pa.; Members of the American Medical Association, and Pennsylvania State Medical Society. Reprinted from the<i>Journal of Nervous and Mental Disease,</i>July, 1891
Authors: C. E. A.
Journal: American Journal of Psychiatry (1891)
Reply
Authors: A S McIntyre, R G Long
Journal: Gut (1994)

EDITOR,-We are glad that Dr Jolobe agreed with the importance of considering coeliac disease in patients with iron deficiency anaemia, even when symptomatology is atypical.The precaution of taking endoscopic biopsy specimens prevents oversight of the diagnosis.We also note his comment on the abnormal appearance of duodenal folds in coeliac disease.We indeed routinely comment on such abnormalities having previously pub- lished evidence' supporting the data of Brocchi et al.'
Of MDs and muscles— lessons from two 'retired steroid doctors'
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Landmark perspective: Abscess of the antrum
Authors: B. J. Bailey
Journal: JAMA (1983)

It is both an honor and a challenge to review and comment on the landmark publication entitled "Diagnosis and Treatment of Abscess of the Antrum," by Joseph H. Bryan, MD, published in the Oct 5, 1889, issue ofThe Journal. Bryan's original manuscript was presented to those assembled at the Section of Laryngology and Otology at the 40th Annual Meeting of the American Medical Association, which was held in June 1889. The great significance of this publication is apparent when it is placed in the context of the location and time of its publication. European physicians were providing most of the advances in rhinology. The brief period between 1886 and 1893 is the interval during which physicians began to become aware of the frequent need for surgical intervention in the management of chronic sinus infection. In 1886, Mikulicz<sup>1</sup>published his important work in Germany, recommending the transnasal, surgical management
Abstract 4009: GLUT3 variant is associated withprognosis of patients with non-small cell lung cancer after surgical resection
Authors: Shin Yup Lee, Sook Kyung Do, Sun Ha Choi, Jin Eun Choi, Hyo Gyoung Kang, Mi Jeong Hong, Dong Won Baek, Seung Soo Yoo, Ji Woong Son, Jae Yong Park
Journal: Cancer Research (2019)

Abstract This study was conducted to explore whether polymorphisms of glucose transporter 3 (GLUT3) gene affect the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Four single nucleotide polymorphisms (SNPs) in GLUT3 were investigated in a total of 782 patients with NSCLC who underwent curative surgery. The association of the SNPs with overall survival (OS) and disease free survival (DFS) was analyzed. Among the four SNPs investigated, GLUT3 rs7309332C&amp;gt;T was significantly associated with OS and DFS in multivariate analyses. The SNP was associated with significantly worse OS (adjusted hazard ratio [aHR] = 1.62, 95% confidence interval [CI] = 1.04-2.53, P = 0.03, under recessive model), and worse DFS (aHR = 1.64, 95% CI = 1.18-2.29, P = 0.003, under recessive model). When stratified by tumor histology, the association between the GLUT3 rs7309332C&amp;gt;T and OS/DFS was not limited to either squamous cell carcinoma (SCC) or adenocarcinoma (AC), although the significant association remained only in AC for OS (P = 0.40 for SCC and P = 0.04 for OS) and only in SCC for DFS (P = 0.03 for SCC and P = 0.08 for OS). When AC patients were stratified according to EGFR mutation status, the SNP was significantly associated with DFS in patients with EGFR mutant tumors (aHR = 2.47, 95% CI = 1.15-5.30, P = 0.02, under recessive model), but not in those with EGFR wild-type tumors. This study suggests that genetic variation in GLUT3 may be useful in predicting survival of patients with early stage NSCLC. Citation Format: Shin Yup Lee, Sook Kyung Do, Sun Ha Choi, Jin Eun Choi, Hyo Gyoung Kang, Mi Jeong Hong, Dong Won Baek, Seung Soo Yoo, Ji Woong Son, Jae Yong Park. GLUT3 variant is associated withprognosis of patients with non-small cell lung cancer after surgical resection [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4009.
Catheterization and Mortality in Elderly Patients With Acute Myocardial Infarction
Authors: Lewis H. Kuller
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Dr McClellan and colleagues<sup>1</sup>unfortunately misinterpret the results from the Health Care Financing Administration administrative hospital discharge database used for the evaluation of invasive coronary diagnostic and therapeutic procedures. The analytic techniques they have applied cannot determine the efficacy or effectiveness of cardiac catheterization or whether they are overused or underused. The problems with their methods of data analysis were discussed in a classic article by Sheps in 1958.<sup>2</sup>In that article, Sheps described the problem of evaluating the efficacy of polio vaccine. For example, consider 100 000 individuals who were given polio vaccine and 100 000 controls. The subsequent rate of clinical polio was 57/100 000 in the controls and 16/100 000 in the intervention group. The difference of 41/100 000, or 0.04%, was so small that policymakers today would probably be advised by outcomes research to reconsider vaccination programs. Now, if we take
NIMG-42. EXPERIENCE WITH 18F-FET PET/MRI FOR CNS-TUMORS IN CHILDREN AND ADOLESCENTS
Authors: Lisbeth Marner, Karsten Nysom, Astrid Sehested, Lise Borgwardt, René Mathiasen, Peder Skov Wehner, Otto Mølby Henriksen, Michael Lundemann, Carsten Thomsen, Lars Bøgeskov, Jane Skjøth-Rasmussen, Helle Broholm, David Scheie, Marianne Juhler, Liselotte Højgaard, Ian Law
Journal: Neuro-Oncology (2017)

Positron Emission Tomography (PET) with 18F-fluoro-ethyltyrosine (18F-FET) improves diagnostic accuracy in adult patients with gliomas but the literature in pediatric neuro-oncology is still scarce. We aimed 1) to collect a material of various pediatric brain tumors 2) to determine sensitivity and specificity for tumor using 18F-FET PET versus MRI alone 3) to test the clinical impact of the scans. Eighty patients with primary pediatric CNS-tumors was included and a total of 121 hybrid 18F-FET PET/MRI or PET/CT scans have been performed. Clinical impact was assessed as minor (change of diagnosis) or major (change of treatment plan). Minor impact was seen in 28% of all scans and major impact in 9%. In the 27 cases, when a PET scan had beforehand been regarded clinically indicated, 38% showed minor impact and 35% showed major impact. A high uptake was seen in pilocytic astrocytoma and in high grade gliomas, while lower uptake was seen in e.g. AT/RT (atypical teratoid/rhabdoid tumor), ependymoma, germinomas. No increased uptake was seen in e.g. non-contrast enhancing low grade glioma. In 24 early postoperative 18F-FET PET scans conducted primarily within 72 hours after surgery, minor impact was seen in 42% and major impact in 4% of cases. Based on a consensus reading for residual tumor of follow-up scans (up to 24 months), we found the following lesion-based sensitivity/specificity/accuracy for diagnosing residual tumor: MRI alone: 80%/64%/72%. PET/MRI: 73%/100%/86%. The addition of 18F-FET PET to MRI for imaging of pediatric CNS-tumors has a major impact on the clinical management in 9% of all scans and in 35% of the clinically indicated scans. The addition of 18F-FET PET for early postoperative imaging seems to increase the specificity for residual tumor and should be considered when radical surgery is of high priority, especially if MRI is equivocal.