tbuckley/cabot-search huggingface dataset:
TEN MILES ABOVE THE EARTH
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Validation of interleukin-32 as a new circulating fatty liver biomarker
Authors: Guido Alessandro Baselli, Paola Dongiovanni, Raffaela Rametta, Marica Meroni, Serena Pelusi, Marco Maggioni, Sara Badiali, Piero Pingitore, Samantha Maurotti, Tiziana Montalcini, Alice Taliento, Daniele Prati, Giorgio Rossi, Anna Ludovica Fracanzani, Rosellina Mancina, Stefano Romeo, Luca Valenti
Journal: Journal of Hepatology (2020)
Sino-orbital aspergillosis treated with combination antifungal therapy. Successful therapy after failure with amphotericin B and surgery
Authors: V. L. Yu
Journal: JAMA (1980)

ASPERGILLOSIS of the paranasal sinus and orbit is well recognized.<sup>1</sup>Local invasion of the sinus or orbit by<i>Aspergillus</i>has been managed successfully with surgery, whereas amphotericin B as sole therapy is considered inadequate.<sup>1</sup>However, when sinus invasion is complicated by decreasing visual acuity and neurological signs, the course has invariably been fatal, even when aggressive surgery was combined with amphotericin B therapy. (A reference list will be provided with reprint requests.) We present a case of sinus aspergillosis that showed malignant progression despite surgery, treatment with amphotericin B, and the results of in vitro susceptibility testing for the fungus involved. When combination antifungal therapy (viz, addition of flucytosine and rifampin to the amphotericin B regimen) was instituted, a dramatic clinical response was noted, with gradual resolution of symptoms and neurological abnormalities. <h3>Materials and Methods</h3> Susceptibility testing was performed by the broth dilution method, using yeast nitrogen base
Erratum
Journal: BMJ (1887)

have been used; and yet we have lived to see how this same ambulance system, notwithstanding this unworthy opposition, and that arising out of antiquated notions and military prejudices; and, in spite of all the taunts and sneers levelled against it, has become an integral part of the army, and is now developing into a great national movement-thanks to the public spirit and enthusiasm of our civilian brethren-in connection with the volunteer forces, with divisions in the chief military centres, and ramifications in the universities and medical schools of the kingdom.In fact (in the words of a military critic) it constitutes "a distinct increase in the military strength of the empire."Uniformity of drills and parades are enjoined by regulation as well as inspections by administrative medical officers with a view to its thorough efficiency.Of its great efficiency in actual war, where there was no " playing at soldiers," but, alas I where all was stern reality, we have had ample, though sad and con- vincing, proof in the accounts given by various special correspondents of the work done in the late campaigns in the Upper Nile and in the Eastern Soudan, in both of which success was " signal and complete."PAY OF MEDICAL OFFICERS AND MR.ACCOUNTANT-GENERAL KNOX.X. Y. Z. sends the following table to show that the Royal Warrant of 1879 only levelled up the pay of officers of the Medical Staff to that of other staff officers, and says: Even now our surgeons-general draw less daily paythan major,adjutant, or commissary generals ; our surgeon lieutenant-colonels only the same as a major of Royal Engineers ; and our surgeons-captain only 2d. more then a lieutenant of Royal Engineers of three years' service.Grade.
The cost of Marinol (dronabinol)
Authors: K. V. Shepard
Journal: JAMA (1993)

<h3>In Reply.</h3> —Drastic problems require the consideration of drastic solutions; if not sooner, more drastic later. Our imbalance of generalists and specialists has been developing for a long time. The new marketplace will correct it. The move back is just beginning nationally but is already advanced in some American locales. Our oversupply of many specialists and subspecialists will become apparent to nearly all in the very near future. Competent primary care physicians will be in great demand. What will happen to the physicians in the oversupplied specialties? The "best" ones will remain as specialists and subspecialists; the quick and lucky others will get first in line to retrain to become competent in and practice primary care in the new systems. The slow and the resisters will try to move geographically, buying some time. Early retirement or joblessness will then result for the unfortunate. Resistance will be extreme. Many specialists will
Vitamin D: a reawakening
Authors: P. A. Palmisano
Journal: JAMA (1973)

Clear descriptions of the clinical picture of rickets were published in the 17th century although mention of various aspects of the syndrome goes back even further. That a chemical factor could reverse the rachitic process was well settled by the mid-1920s. It is now clear that a number of sterols can be rendered antirachitic under the influence of ultraviolet irradiation. The significant sterols, in this regard, are ergosterol (derived from plant sources) and 7-dehydrocholesterol (from animals). When appropriately irradiated, these compounds form ergocalciferol (vitamin D<sub>2</sub>) and cholecalciferol (vitamin D<sub>3</sub>), respectively. Historically, "vitamin D<sub>1</sub>" was really found to be a mixture of substances and not a separate entity. <h3>Vitamin D in Man</h3> Of course, irradiating many types of plant or animal sterols will produce therapeutic amounts of D<sub>2</sub>or D<sub>3</sub>that can prevent or cure rickets when ingested. But it has been known for generations that irradiating
Liver injury, repair and replacement
Authors: T Ebowlig, J Ri& -Polwon, A Catterall, M Conway, E Brown, J Curtis, J Coleman, M Murray-Lyon, T Hendickse, D Ri
Journal: Gut (1992)

Cardiac afrhythmias have been observed during gastroscoy, and it has been suggested that the hypoxia induced dunng the procedure is a causal factor.Medhods: 103 patients over 60 years at routine gastrosoy were randomised to receive either supplemental oxygen or air at 2 /mim during the edure.Pulse, blood pressure, oxygen saturation and ECG were mohitored before, during and for one hour after the g y-Resuts: Abnorma' EC.G's were seen in th:re cn air/oxygcn in 94%/88% before, 77%/68% during and 92%/90% after gastrscopy.Most arrhytuihas recorded were supraventricular (SVE) and ventricular ectopics (VE), but there were other arrhythmias seen.Both VE and ST segment chane occred equally within the two groups.SVE were seen in sgnificantly more patients during gastroscopy (p < 0.05) in those receiving air (49%) than in those receiving oxygen (30%).However, their frequency when present was similar both in the oxygen and air groups, and between the three monitored periods.Although supplemental oxygen duringgastroscopy improved oxygen saturation significantly by 3.6% (p < 0.001; 95% confidence intervals for the difference between the means: 2.9-4.7),there was no correlation between oxygen saturation or its rise and any ECG changes.Similarly there was no relationship between the incidence of arrhytmas or ST segment change and patient charactenstics, such as age or cardiopulmonary history.Condcuion: ECG abnormalities are common in patients over 60, but this study found no evidence that they are induced by gastrscopy.Supplemental oxygen increases oxygen saturation but does not reduce the incidence of cardiac arryhtmias or ST segment .
Oral ciprofloxacin after a short course of intravenous ciprofloxacin in the treatment of spontaneous bacterial peritonitis: results of a multicenter, randomized study
Authors: R Terg, S Cobas, E Fassio, G Landeira, B Ríos, W Vasen, R Abecasis, H Ríos, M Guevara
Journal: Journal of Hepatology (2000)
Abstract P165: The Long-term Effect of a Low-Carbohydrate Diet on Endothelial Dysfunction and Insulin Resistance: A Randomized Controlled Trial
Authors: Tian Hu, Kristi Reynolds, Lu Yao, Calynn Bunol, Yanxi Liu, Chung-Shiuan Chen, Jiang He, Lydia Bazzano
Journal: Circulation (2013)

The long-term effects of low-carbohydrate diets versus low-fat diets on endothelial dysfunction and insulin resistance are unclear. A total of 148 study participants with a body mass index of 30 - 45 kg/m2 (Mean: 35.4 kg/m2) who were free of diabetes, cardiovascular diseases and kidney disease were recruited. The participants were randomly assigned to either a low-carbohydrate diet (&lt;40 g/day; N=75) or a low fat (&lt;30% energy from fat, &lt;10% from saturated fat; N=73) diet. Two 24-hour dietary recalls were conducted at each clinic visit (0, 3, 6 and 12 months of intervention). Participants met with a study dietitian weekly for the first month followed by group settings bi-weekly for 5 months and monthly for the last 6 months. Each group was provided the same behavioral curriculum related to diet emphasizing portion control and eating habits. Biomarkers for endothelial function and insulin resistance included E-selectin, Intercellular Adhesion Molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), Insulin-like growth Factor-1 (IGF-1), serum insulin, and glucose. Mixed-effect regression models including group, time and their interaction were used to analyze the data. Of the study participants, 60 in the low-fat group (81.1%) and 59 in the low-carbohydrate group (79.7%) completed the entire intervention. The mean age was 46.8 years, 88.5% were women and 55.1% were African-Americans. The low-carbohydrate group lost approximately 3.5 kg more body weight than did the low-fat group (P= 0.002) on average. Compared to the low-fat diet, the low-carbohydrate diet resulted in greater reductions in E-selectin (net change: -4.5, -4.3, and -3.8 ng/mL at 3, 6, and 12 months, respectively; overall P= 0.002) and ICAM-1 (net change: -7.3, -10.4, and -16.8 ng/mL at 3, 6, and 12 months, respectively; overall P= 0.06). There was no significant change in any other markers. Our findings suggest that the low-carbohydrate is at least as effective as the low-fat diet at improving endothelial dysfunction and insulin resistance.
Lessons from Lipitor and the broken blockbuster drug model
Authors: None The Lancet
Journal: The Lancet (2011)

Pfizer's LDL cholesterol-lowering atorvastatin (Lipitor) defines what it means to be a blockbuster drug. Patented in 1997, it has raked in around US$130 billion for Pfizer during its 14 years on the market, making it the world's bestselling drug of all time. Indeed, Pfizer's business model has relied on the huge profits from Lipitor and a few other blockbuster drugs. But things are set to change. The patent for Lipitor expired on Nov 30.
OP0154 Altered lymph node stromal cells during the earliest phases of rheumatoid arthritis
Authors: C Ospelt, E Karouzakis, J Hähnlein, JF Semmelink, RE Gay, PP Tak, DM Gerlag, S Gay, LG van Baarsen
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Lymph node stromal cells (LNSC) play a crucial role in shaping the immune response and maintaining peripheral tolerance. We developed an experimental model for studying the functional capacities of human LNSC during the earliest phases of RA and compared their cellular and molecular characteristics to LNSC from healthy volunteers. <h3>Methods</h3> ACPA+ RA patients (n=24), ACPA+ RA-risk individuals (n=23) and seronegative healthy controls (n=14;HC) underwent ultrasound-guided inguinal lymph node biopsy. Human LNSCs were isolated and expanded <i>in vitro</i> for cellular (flow cytometry), molecular (methylome, transcriptome and microRNA) and functional (contraction) analyses. <h3>Results</h3> RNA sequencing was performed on LNSC of HC (n=5), ACPA+ RA-risk individuals (n=6) and ACPA+ RA patients (n=4). Of interest, LNSC from ACPA+ RA-risk individuals and ACPA+ RA patients were more similar to each other compared with HC. Pathway analysis of commonly increased genes in RA (-risk) LNSC showed, among others, significant enrichment of pathways affecting actin cytoskeleton, focal adhesion and cell junction. DNA methylation (Illumina HumanMethylation450 array) analyses revealed 459 differentially methylated CpG sites (DMS) in LNSC from ACPA+ RA patients (n=5) versus HC (n=4), 504 DMS between ACPA+ RA-risk individuals (n=3) versus HC and 665 DMS when comparing RA patients with RA-risk individuals (delta β-value &gt;0.1, p&lt;0.05). 34 DMS were different in both RA and RA-risk LNSC compared to healthy LNSC. 80% of these DMS were significantly hypomethylated and associated with antigen processing and presentation (HLA-DRB1), immune response and regulation of actin cytoskeleton. Accordingly, in a gel contraction assay LNSC from ACPA+ RA-risk individuals and RA patients showed impaired collagen contraction compared to healthy LNSC. Healthy LNSC (n=5) covered 26.5% +/-2.5 of the well, while RA-risk (n=4) and RA (n=5) LNSC only covered 33.9% +/-5.9 and 30.6% +/-6.5. <h3>Conclusions</h3> This data point towards alterations in the cytoskeleton and antigen-processing and presentation in LNSC from ACPA+ RA-risk individuals and RA patients. Further studies are required to investigate the influence of this LNSC abnormality on immune responses. <h3>Disclosure of Interest</h3> C. Ospelt: None declared, E. Karouzakis: None declared, J. Hähnlein: None declared, J. Semmelink: None declared, R. Gay: None declared, P. Tak Employee of: GSK, D. Gerlag Employee of: GSK, S. Gay: None declared, L. van Baarsen: None declared
Aerospace Medicine
Authors: William F. Ashe
Journal: JAMA (1961)

It is exceedingly difficult if not impossible to write what the editor, Dr. Harry G. Armstrong, calls a "complete treatise" on aerospace medicine. Hence it is not surprising that Dr. Armstrong and his colleagues have failed. No particular criticism should or would accrue had they only updated aviation medicine to or near the publication date of 1961, but that wasn't done either. Too much discussion is given to pre-1955 military flight medicine and too little to the numerically much larger group of civilian problems. The text, taken literally, would have one believe pilots over 50 don't exist, women never are pilots ( see Page 29), crop dusting with its flight, noise, vibration, fatigue, and toxic hazards is virtually nonexistent, and the inflight health of thousands of U.S. executives is the business of someone else. Yet this book is the text in this field and is a must for students of the
The President’s Program and a Department of Health
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Figure
Authors: Zachary Holcomb, Sadaf Hussain, Jennifer Huang, Sophia Delano
Journal: JAMA Dermatology (2021)

Naoki Oiso, MD, PhD; Shigeto Yanagihara, MD, PhD; Chiharu Tateishi, MD, PhD; Norito Ishii, MD, PhD; Takashi Hashimoto, MD, PhD; Daisuke Tsuruta, MD, PhD; Akira Kawada, MD, PhD
Physicians' Families and Payment for Medical Care
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Re: How Does the MRP/GS-X Pump Export Doxorubicin?
Authors: HENK J. BROXTERMAN, MARC HEIJN, JAN LANKELMA
Journal: JNCI Journal of the National Cancer Institute (1996)

Hawaii.In our recently published cohort study (7), we observed the presence of atrophic gastritis in 62% of 24 cagApositive patients, compared with 32% of 34 cagA-negative patients, corresponding with an odds ratio (OR) of 3.48 (95% confidence interval [CI] = 1.02-12.2).In a previous, prospective, nested case-control study (2), we observed the development of gastric cancer in 109 subjects who had had a phlebotomy 13 ± 5 years (mean ± standard deviation) earlier.On the basis of serologic testing, 103 (94%) of these subjects had been infected with H. pylori at the time of bleeding.In an extension of this study, it appeared that 90 (87%) of these 103 patients with gastric cancer had been infected with cagA-positive strains (J).This proportion was 78% in 103 matched H. py/on-infected control subjects who did not develop gastric cancer during follow-up, corresponding with an OR of 1.9 (95% CI = 0.9-4.0)(3).The association between infection with a cagA-positive H. pylori strain and gastric cancer was strongest for intestinal-type carcinomas of the distal stomach (OR = 2.3; 95% CI = 1.0-5.2) (J).Ponzetto et al. found cagA antibodies in 96% (95% CI = 87-100) of 51 patients with gastric cancer.This percentage is in agreement with our previous findings, but is remarkably high considering that the specimens were from patients who already were diagnosed as having cancer.During the process of the development of atrophy and cancer, signs of a pre-existing H. pylori infection may disappear (4).The 18% prevalence of cagA antibodies in the control subjects, on the other hand, seems rather low when compared with other studies.It is not clear whether or not all of the 555 consecutive individuals tested were H. pylori positive.
Book Review Bone-Grafting in the Treatment of Fractures. By J. R. Armstrong, M.D., M.Ch., F.R.C.S. With a foreword by R. Watson-Jones, B.Sc, M.Ch.Orth., F.R.C.S. 8°, cloth, 175 pp., with 204 illustrations. Baltimore: Williams and Wilkins Company, 1945. $7.00.
Journal: New England Journal of Medicine (1946)
Obtaining tax-exempt status
Authors: S. E. Seltzer
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection
Authors: Oliver Bannard, Robert M. Horton, Christopher D.C. Allen, Jinping An, Takashi Nagasawa, Jason G. Cyster
Journal: Immunity (2013)

(Immunity 39, 912–924; November 14, 2013) In the version of this paper originally published online, Tables S1–S3 were omitted. The Supplemental Information has now been corrected, and the journal regrets the error. Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective SelectionBannard et al.ImmunityOctober 31, 2013In BriefGerminal center (GC) B cells cycle between the dark zone (DZ) and light zone (LZ) during antibody affinity maturation. Whether this movement is necessary for GC function has not been tested. Here we show that CXCR4-deficient GC B cells, which are restricted to the LZ, are gradually outcompeted by WT cells indicating an essential role for DZ access. Remarkably, the transition between DZ centroblast and LZ centrocyte phenotypes occurred independently of positioning. However, CXCR4-deficient cells carried fewer mutations and were overrepresented in the CD73+ memory compartment. Full-Text PDF Open Access
Cardiac Decompensation
Authors: Alberto Ramírez, Walter H. Abelmann
Journal: New England Journal of Medicine (1974)

THE present communication will address itself to the management of acute and life-threatening cardiac decompensation and stress the pathophysiologic approach. Although heart failure may be the final common-pathway result of most heart disease and respond to certain therapeutic interventions irrespective of cause, optimal therapy and rehabilitation require identification of both primary, specific, and secondary, contributory, causes of decompensation. This goal can be achieved only by complete early history, physical examination and laboratory evaluation with periodic follow-up study, since some primary or secondary causes may not be readily apparent — e.g., valvar stenosis or hyperthyroidism.In the majority of patients, the . . .