tbuckley/cabot-search huggingface dataset:
HISTOCHEMISTRY AND EARLY MYOCARDIAL INFARCTION
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hensing, 1719: An Account of the First Chemical Examination of the Brain and the Discovery of Phosphorus Therein.
Journal: Annals of Internal Medicine (1983)

Reviews of publication of Psychopathia sexualis is 1886 (and not 1866; see p. 27); William Battie had nothing to do with Bethlem Hospital (p.25); etc.The chapter on Swiss psychiatry that follows finds the author on safer ground and his thumbnail sketch is lively and adequate.Some important references on this topic are missing, however, particularly Lunier's classical paper on 'De l'alienation mentale en Suisse' (1867).The third chapter (on treatments) is again weak, occasionally unfair (e.g., against ECT; p. 54), and sometimes controversial (e.g. on the useful- ness of intravenous antidepressants, p. 54).The second section totally justifies the publication of this book.It offers an original and welldocumented account of the contributions of many important figures of Basle psychiatry.The material is organized biographically and the attempts by the author to identify links between his heroes and the ongoing intellectual scene in the rest of Europe are very successful.Some of the psychiatrists discussed (e.g.Wille and Ruidin) are better known to non-Swiss historians than others (e.g.Brunner, Wolff, Staehling, and a constellation of minor figures).Wille was presented in detail by Meyer (1973) but still remains an intriguing figure.Surprisingly, Dr Haenel does not mention Wille's superb paper on Verwirrheit (1888), which is a crucial contribution to the development of the concept of delirium.Dr Haenel writes in a terse and elegant German, and his book is a pleasure to read.Well- known and less well-known photographs have been interleaved, and misprints have been kept to a minimum.With this work, Haenel has rendered a great service to the psychiatry of his country, and the book should find a rightful place in all specialized libraries.
Contents Vol. 27, 1995
Authors: C Schulman, Brussels Boccon-Gibod, S Karger, J Ferguson, D Bostwick, V Suman, H Zincke, J Oesterling, J Fishwick, J Bruce, G Collins, B Yanovski, O Nativ, J Ekengren, W Zhang, R Hahn, P Puppo, M Perachino, G Ricciotti, W Bozzo, M Galiucci, G Carmignani, F Pagano, M Maffezzini, F Montorsi, G Guazzoni, Di Silverio, F Morelli, M Muto, P Vegt, F Debruyne, L Palmer, E Laor, W Skinner, B Tolia, R Reid, S Freed, G Jakse, K Planz, B Redpath, A Kendrick, S Whyte, B Clarke, D Verbeeck, R Ghoniem, G Monga, H Frohmüller, M Theiss, A Manseck, M Wirth, K Kashif, H Lewi, A Kadioglu, T Erdogru, K Karçidag, N Dinççag, I Satman, M Yilmaz, S Tellaloglu
Journal: European Urology (1995)

ing, microcopying, or by any information storage and re trieval system, without permission in writing from the pub lisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center (see 'Infor mation for Readers and Subscribers'). Drug DosageThe authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication.However, in view of ongoing research, changes in government regulations, and the con stant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions.This is particularly impor tant when the recommended agent is a new and/or infre quently employed drug.
Control of Accidents in Rural Areas
Authors: Julian A. Waller
Journal: JAMA (1967)

<h3>To the Editor:—</h3> During the interval between the first presentation of this topic at the National Conference on Rural Health in March 1966, and the recent publication inThe Journal(<b>201</b>:176, 1967), substantial changes have occurred in a number of areas within the accident field. One of the more important of these was a decision by the Department of Labor concerning wages of ambulance personnel. This has almost doubled the cost of maintenance of ambulance services. The National Highway Safety Act of 1966 has led to establishment of federal standards requiring states to improve emergency medical services available to traffic victims. This is part of a broad program of accident control, which harmonizes with the establishment by the American Medical Association of a Committee on Emergency Medical Services. This committee has already held one major conference for the medical profession in April 1967, and plans a second much more
A Manual of Hypodermatic Medication.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The future of pediatrics
Authors: J. M. Mercola
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The American Medical Association's Council on Long Range Planning and Development and the American Academy of Pediatrics<sup>1</sup>have provided a fine analysis of some key factors that will influence the future practice of pediatrics. However, it seems rather curious that in their consideration of the elements that will influence the future of the specialty these prestigious organizations have chosen to ignore the impact of the acquired immunodeficiency syndrome (AIDS) epidemic. It is difficult to make accurate predictions of the future, but any projection to the year 2000 that does not attempt to factor in AIDS will be dangerously flawed. Several investigators have estimated that there may currently be between 3 and 4 million HIV carriers in our country.<sup>2,3</sup>If the epidemic continues to spread at current rates, one third of our population may be infected by the year 2000. The social and economic chaos created
Cigarette Smoking Among Women of Reproductive Age—United States, 1987-1992
Journal: JAMA (1994)

Women who smoke cigarettes are at increased risk for lung cancer, chronic obstructive pulmonary disease, and complications of oral contraceptive use. During pregnancy, cigarette smoking increases the risks for a low birthweight infant and infant mortality. A national health objective for the year 2000 is to reduce cigarette smoking among women of reproductive age (i.e., 18-44 years) to a prevalence of no more than 12% (objective 3.4h)(1). This goal is substantially lower than the estimated baseline prevalence of 29% measured by CDC's 1987 National Health Interview Survey (NHIS). To characterize recent trends in cigarette smoking and monitor progress toward the year 2000 objective, data from the NHIS for 1987 through 1992 were analyzed for women aged 18-44 years.
Medical Manpower
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Percutaneous implantation of large stents for the treatment of infants with severe post-operative branch pulmonary artery stenoses Frank F. Ing, James C. Perry, James W. Mathewson, Mark Cocalis, Kathleen Maginot, Charles E. Mullins. Children's Hospital of San Diego, San Diego, CA, Texas Children's Hospital, Houston, TX
Journal: Journal of the American College of Cardiology (2001)
Research on Children's Anxiety Needed
Authors: M. Mitka
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Potential Health Implications for Acid Precipitation, Corrosion, and Metals Contamination of Drinking Water
Authors: William E. Sharpe, David R. DeWalle
Journal: Environmental Health Perspectives (1985)

Potential health effects of drinking water quality changes caused by acid precipitation are presented. Several different types of water supply are discussed and their roles in modifying acid rain impacts on drinking water are explained. Sources of metals contamination in surface water supplies are enumerated. The authors present some results from their research into acid rain impacts on roof-catchment cisterns, small surface water supplies, and lead mobilization in acid soils. A good correlation was obtained between cistern water corrosivity as measured by the Ryznar Index (RI) values and standing tapwater copper concentrations. However, lead concentrations in tapwater did not correlate well with cistern water RI. A modified linear regression model that accounted for Ryznar Index change during storage in vinyl-lined cisterns was used to predict the Ryznar Index value at a copper concentration of 1000 micrograms/L. The predicted RI was greater than the RI of precipitation with a pH of 5.3, indicating that anthropogenically acidified precipitation may result in cistern tapwater copper concentrations in excess of the 1000 micrograms/L suggested drinking water limit. Good correlations between tapwater Ryznar Index and tapwater copper and lead concentrations were not obtained for the small surface water supply. Aluminum concentrations in reservoir water were similar to those in stream source water. Limited data were also presented that indicated lead was present in acid forest soil leachate and streams draining such soils in relatively small concentrations. Where appropriate, recommendations for future research are included with the discussions of research results.
Plastic Surgery
Authors: Donald Serafin
Journal: JAMA (1979)

During the past decade, the specialty of plastic surgery has contributed to notable advances in microsurgery, craniofacial surgery, hand surgery, and other difficult reconstructive problems. Important contributions have also been made in the design and use of musculocutaneous flaps and to pioneering efforts in breast reconstruction for mastectomy patients. Emphasis is also being directed to the contralateral breast because of its recognized premalignant potential. <h3>Microsurgery</h3> With the advent of small-vessel anastomosis in the 1960s, it became possible to anastomose vessels as narrow as 1.0 mm in external diameter, with predictable patency rates. Reports soon appeared in the world literature describing the successful replantation of digits and even entire limbs. Many investigators were encouraged to review the physiology of the microcirculation and to investigate factors that influenced the viability of transferred tissue. Successful replantation efforts permitted innovative surgeons to review existing methods of reconstruction and to recognize their limitations. In 1972
Cost-effectiveness of pembrolizumab as second-line therapy for the treatment of locally advanced or metastatic urothelial carcinoma in the United States.
Authors: Yichen Zhong, Yizhen Lai, Haojie Li, Rachael Batteson, Yang Meng, Tara L. Frenkl, James Luke Godwin, Guru Sonpavde
Journal: Journal of Clinical Oncology (2019)

e16010 Background: Pembrolizumab is approved by the US Food and Drug Administration for the treatment of locally advanced or metastatic urothelial carcinoma (mUC) following platinum-based chemotherapy, based on results from KEYNOTE-045. In this randomized phase 3 trial, pembrolizumab significantly prolonged overall survival (OS) vs. chemotherapy in mUC patients (cut-off: Oct 26, 2017). The current analysis evaluates the cost-effectiveness of pembrolizumab vs. standard-of-care chemotherapy (docetaxel or paclitaxel) as second-line (2L) treatment for mUC, from a US payer perspective. Methods: We developed a partitioned-survival model to measure the costs and effectiveness over a 20-year time horizon to capture long-term costs and benefits from the treatments. Clinical efficacy, time on treatment, safety and utility data were derived from KEYNOTE-045. OS and progression-free survival were extrapolated beyond the trial period using piecewise models, i.e., Kaplan-Meier data followed by parametric function. Costs (in 2018 $US) for drug acquisition/administration, disease monitoring, adverse events management and terminal care were included. Costs and outcomes were discounted at 3% per year. Deterministic and probabilistic sensitivity analyses were conducted to assess the robustness of the results. Results: Pembrolizumab resulted in a mean gain of 1.33 life years (LYs) and 1.14 quality-adjusted life-years (QALYs) at an incremental cost of $103,861 vs. chemotherapy. The incremental cost-effectiveness ratios were $91,103/QALY and $78,254/LY. Key drivers of cost-effectiveness were extrapolation methods for OS data, time horizon and utility values. Pembrolizumab had a 72% or 100% probability of being cost-effective vs. chemotherapy at a $100,000 or $150,000 willingness-to-pay threshold, respectively. Conclusions: Pembrolizumab appears to be cost-effective vs. docetaxel or paclitaxel monotherapy as 2L mUC therapy when accounting for durable survival seen in a subset of patients receiving pembrolizumab. The model was established based on robust estimates, with key clinical endpoints directly drawn or derived from patient level data in KEYNOTE-045.
Abstract 3031: The receptor tyrosine kinase layer of breast cancer cell lines is predictive of the response to therapeutic drugs.
Authors: Mario Niepel, Marc A. Hafner, Emily A. Pace, Birgit Schoeberl, Peter K. Sorger
Journal: Cancer Research (2013)

Abstract Currently, clinicians use the levels of the hormone receptors for estrogen (ER) and progesterone (PR) and amplifications of the ErbB2 receptor tyrosine kinase (RTK) to distinguish three groups of breast cancers and guide the choice of therapeutic treatments. In this work we show that a limited number of measurements characterizing breast cancer cell lines at the level of RTKs can be used to predict cell line sensitivity to therapeutic inhibitors. We chose a panel of approximately 40 breast cancer cell lines, treated them with 22 different growth factors and cytokines at a saturating and subsaturating dose for 10, 30, and 90 min and measured the phosphorylation of key kinases downstream of the receptors. In addition, we measured the expression and phosphorylation levels of approximately 20 RTKs under serum starvation conditions. We used the measurements to predict the GI50 values of the cell lines in response to over 45 therapeutic inhibitors by partial least square regression. We found that our measurements are sufficient to predict the response to about half of the drugs studied. The majority of drugs we are able to predict target RTKs directly or kinases immediately downstream of the receptors. In some cases we are able to predict the response to drugs that target processes seemingly unrelated to our measurements. We are currently exploring the data to uncover what drives sensitivity and resistance to drugs, gain mechanistic insight in the action of cancer therapeutics, and find predictors of drug response that may be useful in a clinical setting. Our results suggest that a carefully selected set of measurements might be sufficient to classify responsiveness of breast cancers to a number of cancer drugs currently used in the clinic. This is particularly relevant in the case of cancers like triple negative breast cancers for which choosing effective treatment has proven difficult. Citation Format: Mario Niepel, Marc A. Hafner, Emily A. Pace, Birgit Schoeberl, Peter K. Sorger. The receptor tyrosine kinase layer of breast cancer cell lines is predictive of the response to therapeutic drugs. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3031. doi:10.1158/1538-7445.AM2013-3031
Incorrect Statistical Measures and Typographical Errors
Authors: Manuele Casale, Lorenzo Sabatino, Fabrizio Salvinelli, Nicholas Reed
Journal: JAMA (2017)

Christine Roffe, MD; Tracy Nevatte, PhD; Julius Sim, PhD; Jon Bishop, PhD; Natalie Ives, MSc; Phillip Ferdinand, MRCP; Richard Gray, MSc; for the Stroke Oxygen Study Investigators and the Stroke OxygenStudy Collaborative Group
RELATION OF PHARMACY TO THE MEDICAL PROFESSION.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Intra-Uterine Parabiotic Syndrome and Its Complications
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preventive medicine and public health
Authors: W. H. Foege
Journal: JAMA (1993)

The two foundation stones of public health have not changed. The philosophical base continues to be social justice in the application of scientific knowledge. The science base for defining problems, developing interventions, and measuring results is still epidemiology. However, as preventive medicine and public health make contributions in areas that were beyond our comprehension a professional lifetime ago, it is now not only accepted, but expected, that state and local health departments will respond to problems such as lead exposure, occupational hazards, tobacco, dietary fat, suicide clusters, violence, birth defects, and alcohol and other drug abuse. While the logic is inescapable, public health was slow to accept and even seek out the expertise of the social and behavioral sciences. Whether dealing with acquired immunodeficiency syndrome (AIDS) and its prevention, the treatment of tuberculosis, smoking cessation, or child abuse, the major intervention strategies require understanding human behavior, motivations, incentives, and thought