tbuckley/cabot-search huggingface dataset:
Glutathione Effects on Toxicity and Uptake of Mercuric Chloride and Sodium Arsenite in Rabbit Renal Cortical Slices
Authors: Carmen A. Burton, Kristina Hatlelid, Kevin Divine, Dean E. Carter, Quintus Fernando, Klaus Brendel, A. Jay Gandolfi
Journal: Environmental Health Perspectives (1995)

The mechanism of renal uptake of nephrotoxic heavy metals such as HgCI2 and NaAsO2 is not clear.The metals are known to react with endoge- nous sulfhydryls such as glutathione (GSH), so metal-GSH conjugates may be delivered to the kidney.To study this possibility, renal cortical slices from male New Zealand white rabbits were incubated with 104 M HgCI2 or 10-3 M NaAsO2 ± stoichiometric amounts (1-3x) of GSH; or synthetic metal-GSH conjugates [104 M Hg(SG)2 or 1 M As(SG)31.Incubations were performed at 370C in DME-F12 buffer (95/5 02/CO2) for 8 hr.Hg(SG)2 reduced slice K+/DNA content, as an indicator of viability, significantly less than HgCI2.As(SG)3 exhibited a 2-hr delay in K+/DNA content reduction compared to NaAsO2.This delay in toxicity was not correlated to changes in uptake.Arsenic and mercury accumulation, determined by proton- induced X-ray emission, were also identical between the metal salts and the metal-GSH conjugates.Exogenous GSH decreased HgCI2 cytotoxicity and was correlated to a decrease in Hg accumulation in the slice.Exogenous GSH had limited if any protective effects against cytotoxicity by NaAsO2 and a decrease in As accumulation was not observed.Complex metal-GSH interactions appear to exist and impact on the uptake and toxicity of these metals.-
Abstract 2778: Incomplete Neointimal Coverage Two Years after Sirolimus-Eluting Stent Implantation: A Serial Angioscopic Follow-up Study
Authors: Masaki Awata, Jun-ichi Kotani, Masaaki Uematsu, Takakazu Morozumi, Tetsuya Watanabe, Toshinari Onishi, Osamu Iida, Fusako Sera, Hirokuni Akahori, Masamichi Yano, Nobuaki Tanaka, Haruyo Yasui, Kuniyasu Ikeoka, Shin Okamoto, Shinsuke Nanto, Seiki Nagata
Journal: Circulation (2007)

Background- The time course of neointimal formation following sirolimus-eluting stent (SES) implantation has not been extensively studied by angioscopy. Methods- Serial angioscopic findings at 1st (3.6 ± 1.1 months), 2nd (10.5 ± 1.6 months), and 3rd (21.2 ± 2.2 months) follow-ups following stent implantation were compared between SES (n = 17) and bare-metal stents (BMS, n = 11). Neointimal coverage, existence of thrombus and yellow plaques underneath the stents were assessed. Neointimal coverage over the stent was graded as: grade 0 = struts were exposed similarly to the time of implantation; grade 1 = struts were covered, but not embedded; grade 2 = struts were embedded by the neointima; grade 3 = struts were fully embedded and invisible. Results- Neointimal coverage grades were significantly different between SES and BMS at any point of follow-ups (P &lt; 0.001, Figure ). Serial changes were not significant in the BMS group, but the coverage grade slightly increased at the third follow up in the SES group (P&lt; 0.05). Thrombi were detected in 4 SES. Yellow plaques had disappeared by the 2nd follow-up in the BMS group, whereas they were exposed in 71% of SES until the 3rd follow-up. Neointimal coverage grades correlated with thrombi (P=0.002) and yellow plaques (P&lt;0.0001). Conclusions- Neointimal formation was not completed at least up to 2 years following SES, associated with thrombi and yellow plaques. Theses findings suggest the need for long-term dual-antiplatelet therapy after SES implantation.
LETTER FROM LONDON.
Authors: None G. O. M.
Journal: JAMA (1890)

(FROM OUR REGULAR CORRESPONDENT.) Curious Statistics of Longevity—Relative Mortality amongst European Troops—The Effects of Influenza on Hurts and Surgical Accidents and Wounds—Ladies of Title and Foreign Princesses among the Ranks of Trained Nurses—The "Asclepiad" on Fasting—Sulphate of Copper as a Disinfectant—Annual Report of the Inspector of Retreats—A New Spray to produce Local Anœsthesia —Medical Aid for Indian Women—The Inconveniences of Fashions in Medicines. Some curious statistics of longevity have just been published by the German Government. It appears that in 1888 there were ninety-one persons in Prussia who were over a hundred years old, and between 1864 and 1888 upwards of seven thousand persons of over a hundred died, and of these one hundred and fifty-five were more than one hundred and nine. Some details have just been published on the relative mortality amongst European troops during time of peace. As one might suppose, the Spanish troops give the highest
DERMATOLOGIC DIFFICULTIES.
Authors: L. DUNCAN BULKLEY
Journal: JAMA (1899)

The difficulties of dermatology are thought by many to be very great. Apparently the general practitioner often regards the whole subject as almost hopeless, and is frequently content with a very limited consideration of diseases of the skin. The difficulties in the way of mastering completely all the possibilities of dermatology are indeed not light, and even the most experienced will often find trouble in diagnosis and disappointment in treatment. To attempt to point out all dermatologic difficulties would be to produce a textbook on diseases of the skin, so no attempt will be here made to cover all the ground; but it may not be without advantage to direct attention to a few of the points where special difficulties occur, and to make a few practical suggestions in regard to overcoming them. We may briefly consider them under the heads of diagnosis, prognosis and treatment. <h3>Diagnosis.</h3> —While in a
Fiftieth Anniversary Symposium of The Jackson Laboratory
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Fiftieth Anniversary Symposium of The Jackson Laboratory Get access JNCI: Journal of the National Cancer Institute, Volume 62, Issue 4, April 1979, Page 1117, https://doi.org/10.1093/jnci/62.4.1117-g Published: 01 April 1979
Real Life Efficacy and Safety of Dabigatran for Stroke Prevention in Atrial Fibrillation – First Results of the Prospective Noac Registry (NCT01588119)
Authors: Vera Gelbricht, Sebastian Werth, Christina Koehler, Ulrike Haensel, Luise Tittl, Ines Beyer-Westendorf, Thomas Schreier, Jan Beyer-Westendorf
Journal: Blood (2012)
Occupational Handicrafts
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
First evaluation of the Behavioral Addiction Indoor Tanning Screener (BAITS) in a nationwide representative sample
Authors: K. Diehl, T. Görig, E.W. Breitbart, R. Greinert, J.J. Hillhouse, J.L. Stapleton, S. Schneider
Journal: British Journal of Dermatology (2018)

Previous research showed that indoor tanning might have the potential to be addictive. Different screening instruments for indoor tanning addiction exist, however research shows that they are not all suitable for measuring a potential indoor tanning addiction. Due to that a new instrument, the Behavioral Addiction Indoor Tanning Screener (BAITS), was developed. This study from Germany aimed to find out whether the BAITS is an appropriate instrument for screening individuals with symptoms of a potential indoor tanning addiction. The study is based on data from the National Cancer Aid Monitoring on Sunbed Use (NCAM) consisting of cognitive interviews and a nationwide representative telephone survey. Statistical analysis showed that the BAITS seems to be a valid and reliable tool. Altogether, 19.7% of current and 1.8% of former tanning bed users screened positive for symptoms of a potential indoor tanning addiction. However, this is not a final diagnosis of indoor tanning addiction. A final diagnosis would require a more formal assessment. Nonetheless, the BAITS may help physicians and other health care providers to identify individuals in particular need of specific counselling in order to avoid the continuous use of tanning beds. In addition, it is easy to use in large surveys due to its short length and its easily answerable questions.
APPLE News
Journal: Liver Cancer (2019)

AimsPrimary liver cancer is an extremely malignant disease, and 80% of patients are found in Asian countries.The APPLE Meetings have been initiated to provide a platform for regional and international experts to exchange information on the latest advancements in primary liver cancer treatment.The meetings are aimed at bridging gaps in the basic science and clinical aspects of liver cancer among specialists, with the ultimate aim of disseminating the results of laboratory research and clinical trials in liver cancer among professionals. Histor yThe APPLE Meetings take place annually and have been hosted on rotation by the Korean Liver Cancer Study Group, the Liver Cancer Study Group of Japan, and the Chinese Liver Cancer Study Group.The 1st meeting of the group took place in Incheon in 2010, the 2nd in Osaka in 2011, the 3rd in Shanghai in 2012, and the 4th in Busan in 2013.In 2014, APPLE changed its policy and decided to expand its congress venues from three countries to include all Asian countries, and the 5th APPLE Meeting was held in Taipei in 2014.The 6th APPLE Meeting was held in Osaka in 2015, the 7th in Hong Kong in 2016, the 8th in Singapore in 2017, and the 9th in Seoul.
A RUSSIAN NOVELIST'S VIEWS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Food, Health, Vitamins.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Specific Value of Drugs in Psychiatric Illness
Authors: John E. Overall
Journal: JAMA (1965)

<h3>To the Editor:—</h3> A printed sign used to appear in some restaurants, "If you like our meals, tell others; if you don't, tell us." The reverse seems true for clinical studies in psychopharmacology, for without exception, communications made directly to us have praised the work criticized above. Dr. Decker questions the crosssectional approach to evaluation as opposed to a "longitudinal evaluation." Unfortunately, the latter is seldom available, and what data there are frequently represent as much the inferences of the psychiatrist as the symptoms of the patient. He also questions diagnosis, but we thought that we had covered that in the paper; our clinical diagnoses agreed rather well with the computer classification of the rating scale profiles, and we'd be willing to bet that what we called depressed and schizophrenic patients are as close to the common understanding of these terms as it is humanly possible to achieve. Finally, he
Randomized, Placebo-Controlled Trial of Titrated Intravenous Lamifiban for Acute Coronary Syndromes
Journal: Circulation (2002)

Background — Platelet glycoprotein IIb/IIIa inhibitors reduce the rate of death or myocardial infarction among patients with acute coronary syndromes without persistent ST-segment elevation, but their effects may depend on plasma concentrations. We tested whether the addition of lamifiban, titrated to achieve target plasma concentrations, to standard care would improve clinical outcomes. Methods and Results — We randomized 5225 patients at 389 centers in 29 countries to receive a bolus and ≤72-hour infusion of lamifiban or placebo, adjusted for renal function, with aspirin and heparin. The primary end point was the composite of death, myocardial infarction, or severe, recurrent ischemia at 30 days. Baseline characteristics did not differ significantly by treatment. The primary end point occurred in 11.8% of lamifiban-treated patients and in 12.8% of placebo-treated patients (OR, 0.914; 95% CI, 0.769 to 1.087; P =0.329). Bleeding was more common in lamifiban-treated patients, but intracranial hemorrhage was not increased. Among the subgroup who had plasma lamifiban concentrations measured, 91% had a concentration &gt;18 ng/mL at steady state, but their outcomes did not differ from those with lower concentrations. Conclusions — Lamifiban showed no significant effects on clinical outcomes in patients with non–ST-elevation acute coronary syndromes, despite achievement of adequate plasma concentrations.
Hormone treatment of breast cancer
Authors: A. Segaloff
Journal: JAMA (1975)

WHEN patients can be identified as having clinically recurrent and progressive breast cancer, our first choice of therapy generally should be hormonal in nature. Certain patients, ie, those whose only clinical metastatic disease involves the brain, should be treated primarily with whole-brain radiation therapy under the protection of high-dose corticosteroid administration, while patients with rapidly advancing and extensive pulmonary disease may be better candidates for multiple chemotherapeutic regimens that include corticosteroids as initial therapy. Although we hope that the determination of cytoplasmic estrogen receptors may be of assistance in recognizing hormonally responsive patients, neither the state of the art nor the availability of facilities is such at present that we can recommend this as a method for choosing hormonal therapy for patients. It appears, however, that the absence of cytoplasmic estrogen receptors in breast cancer may help to reject patients for hormonal manipulation.<sup>1</sup> <h3>Premenopausal Women</h3> It is generally agreed
Errors in Statistical Numbers and Data
Authors: Robert Bonow, Clyde Yancy
Journal: JAMA Cardiology (2020)

Valentina O. Puntmann, MD, PhD; M. Ludovica Carerj, MD; Imke Wieters, MD; Masia Fahim; Christophe Arendt, MD; Jedrzej Hoffmann, MD; Anastasia Shchendrygina, MD, PhD; Felicitas Escher, MD; Mariuca Vasa-Nicotera, MD; Andreas M. Zeiher, MD; Maria Vehreschild, MD; Eike Nagel, MD
<i>QuickStats</i>: Percentage* of Children and Teens Aged 4–17 Years Ever Diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD),† by Sex and Urbanization§ of County of Residence — National Health Interview Survey,¶ 2013–2015
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

During 2013-2015, the percentage of children and teens aged 4-17 years who had ever received a diagnosis of ADHD was significantly higher among boys than among girls within all urbanization levels. Among boys, those living in small metro and nonmetro micropolitan areas were more likely to have received a diagnosis of ADHD (17.4% and 16.4%, respectively) than were those living in large central (11.4%) and large fringe (12.7%) metropolitan areas. Among girls, those living in large central areas were less likely to have received a diagnosis of ADHD (4.4%) than those living in each of the other five types of urban/rural areas.
Management of acute leukemia: a clue from Africa
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo
Authors: Sarah A. Richman, Liang-Chuan Wang, Edmund K. Moon, Uday R. Khire, Steven M. Albelda, Michael C. Milone
Journal: Molecular Therapy (2020)

(Mol Ther. 28, 1600–1613; July 8, 2020) In the originally published version of this article, Edmund K. Moon was omitted from the list of authors. His name has been added to author list. The authors regret this error. Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In VivoRichman et al.Molecular TherapyJune 10, 2020In BriefTo enable remote control over CAR T cell activity, Richman et al. incorporated a ligand-induced degradation (LID) domain into the CAR. This system created a reversible off switch, depending on the presence or absence of a small molecule ligand, permitting CAR T cell regulation in vitro and in vivo. Full-Text PDF Open Archive
Diseases of the Liver and Biliary System
Authors: Frank L. Iber
Journal: JAMA (1986)

This new edition of a classic text that we have all become accustomed to using has reversed a trend in that it has become smaller. This was accomplished by tighter writing, use of a great number of diagrams that illustrate rather than describe, and printing the references in smaller type than the rest of the text. The organization is logical and, as in earlier editions, the anatomy and physiology are covered in separate sections proportional to their clinical importance. The integration of imaging into all sections is prominent and the illustrations, whether actual photographs or line drawings, amplify the point in the text. The symptoms of liver disease, including hepatocellular failure, encephalopathy, ascites, and portal hypertension and jaundice, are covered in appropriate detail, followed by the clinical presentations. Cholestasis, viral hepatitis, chronic hepatitis, and drugs and the liver receive general treatment before moving on to the specific disorders. Superior discussions
General Walker and Dr. Smith
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal