tbuckley/cabot-search huggingface dataset:
Reoperative Surgery
Authors: Kirby I. Bland
Journal: JAMA (1988)

<i>Reoperative Surgery</i>is a compilation of the viewpoints and experience of recognized authorities on reoperation for major postoperative complications and recurrent physiological disorders common in the practice of general surgery. Considered are reoperations for various organ sites and procedures that have gained increasing clinical and scientific interest. The theme of the text is introduced by Dr Robert M. Zollinger, who reviews "Some Principles of Reoperative Surgery" and enlists preoperative considerations, patient evaluation, techniques, and general considerations for the conduct of the operation and postoperative care. Next is the chapter on anesthetic considerations important in the planning of reoperative strategy. This section concisely depicts the risks and complications of note to the anesthesiologist that pertain to reoperative surgery of various organ sites following hemorrhage, elective reoperations, and cardiac surgery. Chapters 3 through 12 focus on reoperations in various sites of the gastrointestinal tract, including hernias. Specific chapters are devoted to reoperative
Fraud by physicians against Medicaid
Authors: P. Jesilow
Journal: JAMA (1991)

The inauguration of the Medicaid program in the mid 1960s ultimately led to the appearance of a wide range of new forms of illegal behavior by physicians. The fact that government authorities, instead of individual patients, were responsible for payments undoubtedly encouraged the large number of violations. A review of the background of sanctioned physicians shows an overrepresentation of psychiatrists and foreign medical graduates as well as minority-group physicians. Interviews with physicians sanctioned for Medicaid fraud and abuse indicated that they routinely placed the blame for their violations on the program, their employees, patients, or others. In particular, they find program guidelines confusing and irrational and insist that they intrude on what ought to be independent medical judgments. The enforcers, for their part, maintain that the convicted physicians are merely rationalizing self-serving and greedy behavior. (<i>JAMA</i>. 1991;266:3318-3322)
Devolution
Authors: C. I. Clowes
Journal: BMJ (1976)

Electroconvulsive therapy has no long term benefits compared with placebo and often causes brain damage, say <b>John Read</b> and <b>Sue Cunliffe</b>. But <b>Sameer Jauhar</b> and <b>Declan M McLoughlin</b> argue that evidence shows ECT is effective and safe in depression and that adverse side effects can be managed
HGG-18. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA
Authors: Abed Rahman Kawakibi, Rohinton S Tarapore, Sharon Gardner, Andrew Chi, Sylvia Kurz, Patrick Y Wen, Isabel Arrillaga-Romany, Tracy T Batchelor, Nicholas A Butowski, Ashley Sumrall, Nicole Shonka, Rebecca Harrison, John DeGroot, Minesh Mehta, Yazmin Odia, Matthew D Hall, Doured Daghistani, Timothy F Cloughesy, Benjamin M Ellingson, Yoshie Umemura, Jonathan Schwartz, Vivekanand Yadav, Rodrigo Cartaxo, Ruby Siada, Zachary Miklja, Amy Bruzek, Evan Cantor, Kyle Wierzbicki, Alyssa Paul, Ian Wolfe, Marcia Leaoard, Hugh Garton, Rajen Mody, Patricia L Robertson, Guangrong Lu, Krystal Merdinger, Sriram Venneti, Wolfgang Oster, Joshua E Allen, Carl Koschmann
Journal: Neuro-Oncology (2020)

Abstract ONC201, a bitopic DRD2 antagonist and allosteric ClpP agonist, has shown encouraging efficacy in H3 K27M-mutant glioma. Given that the thalamus has the highest extra-striatal expression of DRD2, we performed an integrated preclinical and clinical analysis of ONC201 in thalamic H3 K27M-mutant glioma. ONC201 was effective in mouse intra-uterine electroporation (IUE)-generated H3 K27M-mutant gliomas, with an in vitro IC50 of 500 nM and 50% prolongation of median survival in vivo (p=0.02, n=14). We analyzed thalamic H3 K27M-mutant glioma patients treated with ONC201 on active clinical trials as of 5/22/19 enrollment (n=19 recurrent and 10 post-radiation, non-recurrent; 5–70 years old). As of 12/18/2019, PFS6 and OS12 are 26.3% and 36.8%, respectively, in the recurrent group. For non-recurrent patients, with median follow up of 21.9 months (8.6–26.6) from diagnosis, median PFS or OS have not been reached. This surpasses historical OS of 13.5 months. Best response by RANO includes 1 CR, 3 PR, 4 SD, 8 PD for recurrent patients and 2 PR, 4 SD, 1 PD for non-recurrent patients (4 on-trial patients experienced regressions that are yet unconfirmed responses). Median duration of response for recurrent patients is 14.0 months (2.0–33.1). Furthermore, H3 K27M cell-free tumor DNA in plasma and CSF correlated with MRI response. In summary, single agent ONC201 administered at recurrence, or adjuvantly following radiation, demonstrates promising clinical efficacy in thalamic H3 K27M-mutant glioma patients who currently have no effective treatments following radiation. Investigations are ongoing to assess whether micro-environmental DRD2 expression explains the early exceptional responses in thalamic H3 K27M-mutant glioma.
Use of Cigarettes and Other Tobacco Products Among Students Aged 13-15 Years—Worldwide, 1999-2005
Journal: JAMA (2006)

The use of tobacco in any form is a major preventable cause of premature death and disease. Globally, nearly 5 million persons die every year from tobacco-related illnesses, with disproportionately higher mortality occurring in developing countries. The Global Youth Tobacco Survey (GYTS), initiated in 1999 by the World Health Organization (WHO), CDC, and the Canadian Public Health Association, is a school-based survey that includes questions on prevalence of cigarette and other tobacco use; attitudes toward tobacco; access to tobacco products; exposure to secondhand smoke, school curricula on tobacco, media, and advertising; and smoking cessation. This report presents estimates of self-reported cigarette and other tobacco-product use during 1999-2005 in 132 different countries and the Gaza Strip/West Bank. The data are aggregated within each of the six WHO regions. GYTS data indicate that nearly two of every 10 students reported currently using a tobacco product, with no statistically significant difference between the proportion of those reporting cigarette smoking (8.9%) and other tobacco use (11.2%). Use of tobacco by adolescents is a major public health problem in all six WHO regions. Worldwide, more countries need to develop, implement, and evaluate their tobacco-control programs to address the use of all types of tobacco products, especially among girls.
Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRAS wild-type metastatic colorectal cancer: German AIO study KRK-0306 (FIRE-3).
Authors: Volker Heinemann, Ludwig Fischer von Weikersthal, Thomas Decker, Alexander Kiani, Ursula Vehling-Kaiser, Salah-Eddin Al-Batran, Tobias Heintges, Juergen Lerchenmueller, Christoph Kahl, Gernot Seipelt, Frank Kullmann, Martina Stauch, Werner Scheithauer, Joerg Hielscher, Michael Scholz, Sebastian Mueller, Britta Schaefer, Dominik Paul Modest, Andreas Jung, Sebastian Stintzing
Journal: Journal of Clinical Oncology (2013)

LBA3506 Background: In patients (pts) with KRAS, wild-type metastatic colorectal cancer (mCRC) a head to head comparison of anti-EGFR- and anti-VEGF-directed first-line therapy has not been reported with regard to the FOLFIRI backbone. The AIO KRK-0306 study was therefore designed as a randomized multicenter trial to compare the efficacy of FOLFIRI plus cetuximab to FOLFIRI plus bevacizumab in mCRC pts not pretreated for metastatic disease. Methods: Pts were randomized to FOLFIRI (Tournigand regimen) every two wks plus cetuximab (400 mg/m² day 1, followed by 250 mg/m² wkly = arm A) or bevacizumab (5 mg/kg every two wks = arm B). The intent-to-treat (ITT) population comprised all pts who had at least completed one application of therapy. While recruitment initially was independent of KRAS status, an amendment confined inclusion to KRAS wildtype (WT) tumors. Recruitment was completed in October 2012. The primary study endpoint was objective response rate (ORR, investigators read). Results: Among 735 pts of the ITT-population, KRAS-WT was identified in 592. Of these, 297 pts were randomized to arm A and 295 to arm B. Median age was 64 years, 66% of pts were male, and ECOG PS 0-1 was observed in 98% of pts. Median duration of treatment was 4.7 mo vs 5.3 mo, respectively. While in the ITT analysis, ORR was comparable in arms A vs B (62% vs 57%, odds ratio 1.249), a significant superiority was found for assessable pts in arm A. Median PFS of the ITT population was nearly identical (10.3 vs 10.4 mo, HR 1.04, p=0.69), however, overall survival (OS) showed a significantly better outcome in arm A vs arm B (28.8 vs 25.0 mo, HR 0.77, p=0.0164, 95% CI: 0.620-0.953). Sixty-day mortality was low in both arms (1.01% vs 2.71%). Conclusions: ORR was comparable between arms in the ITT analysis, but favored arm A in assessable pts. Significantly superior OS was observed in KRAS-WT patients receiving cetuximab plus FOLFIRI as first-line treatment. Clinical trial information: NCT00433927.
Motility
Authors: L Rek, A Angi, W Owen, W Owen, J Rothwell, Mtp Caldwell, P Lawlor, P Byrne, T Walsh, Tpj Hennessy
Journal: Gut (1996)

Introduction.The role of duodenal contents in the pathogenesis of Rastro-oesophageal reflux disease (GORD) is not filly understood.Ontil recently oesophageal 'alkaline reflux' on pH monitoring has been taken to imply duodenogastroesophageal reflux.However, usmg Bilitec 2000. it is now possible to detect the presence of duodenal contents in the oesophagus on an ambulatory basis and explore the relationship between pH and bile reflux.Methods.28 patients presenting routinely to this department for further investigation of GORD underwent static manometry, followed by combined dual channel (gastnc and oesophageal) pH and Bilitec monitonng.The oesophageal pH sensor and bile probe were placed 5cm above ttei ally defined lower oesophageal sphincter.Total, upright and supine periods were analysed for pH <4, pH>7 and bilirubin absorbance >0.14.Results.15 (54%0) of the 28 patients had significant acid reflux and 13 (46%) did not.'All patients', those 'with acid reflux' and those 'without acid reflux' were analysed separately.K% total time % total time pH<4 pH>7 median (range) median (range) % total time bilirbin absodbaace>0. 14nmAian traneel.All patients n=284.4 (0.1-24.8) 9.3 (0.8-78.6) 4.7 (0-67.3)Acid reflux n=15 7.5 (4.1-24.8) 7.4 (0.8-34. 1) 5.8 (0-67.3)Noacid reflut n=13 (.8 (0.4.10) 19.8 (1.8-76.8)0.9 0-39.7Statistical analysis revealed a significant correlation between acid reflux and bile reflux in all three groups ( 'all patients' p <0.05, 'acid refux' group p<0.0S, 'no acid reflux group p <o01 Spearman rank correlation).In the 'all patients' group and m the 'acid reflux' group there was a significant correlation between acid and bile reflux m the supine period (p <0.002, p <0.05 respectively).There was no correlation between bile and alkaline reflux in any period in any group ( >0.05).Conclusions.The maority of patients with reflux symptoms have significant oesophageal acid reflux, although some do not.Bile reflux is increased in patients with acid reflux and the two correlate well.Isolated bile reflux in this group was rare (occurnng in only 1 patient).The term 'alkaline reflux' is a misnomer: it does not imply the presence of duodenal contents in the oesophagus.
Marihuana Psychosis
Authors: Doris H. Milman
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The communication entitled "Marihuana Psychosis" by Drs. Talbott and Teague (<b>210</b>:299, 1969) is both important and timely in view of the public debate about marihuana. The authors record surprise in finding "the literature so lacking in regard to adverse reactions to smoking marihuana." In fact, the literature, both current and old contains many more references<sup>1-6</sup>to adverse reactions than Drs. Talbott and Teague note in their bibliography. If the medical community were more aware of the cumulative experience with acute psychotic reactions both in this country and world-wide, there might be a more informed debate about the pros and cons of this drug. A fact not sufficiently emphasized is that marihuana reactions, like those of most other drugs, are dose-related. Hence, the American experience is less impressive than that in Far Eastern areas because here the potency of the drug is less strong and less
Aortoduodenal fistula
Authors: J. A. Pinkerton
Journal: JAMA (1973)

A patient had undergone resection of an abdominal aortic aneurysm 12 years earlier in which a synthetic aortic graft was used. An aortoduodenal fistula occurred at the proximal aortic anastomosis where a false aneurysm had developed, and massive gastrointestinal bleeding resulted. In the absence of infection, the existing grafts were salvaged by division of the fistula, resection of the false aneurysm, and replacement with a new synthetic graft. The patient has had an uncomplicated course and remains well six months postoperatively. A high index of suspicion for this problem is urged for any patient with gastrointestinal bleeding who has a synthetic aortic graft.
Brief Review
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INFECTIOUS DISEASES AND EPILEPSY.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction: Pancreatic Dysplasia
Journal: Annals of Internal Medicine (2000)

Corrections7 March 2000Correction: Pancreatic DysplasiaFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-5-200003070-00022 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In an article on early diagnosis and treatment of pancreatic dysplasia (1), the legend for Figure 1 should have indicated that the diagonal stripes represent patients with pancreatic dysplasia. In addition, Figure 4 shows the histologic features of high-grade dysplasia (carcinoma in situ), not low-grade dysplasia.Reference1. Brentnall TA, Bronner MP, Byrd DR, Haggitt RC, Kimmey MB. Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer. Ann Intern Med. 1999;131:247-55. LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEarly Diagnosis and Treatment of Pancreatic Dysplasia in Patients with a Family History of Pancreatic Cancer Teresa A. Brentnall , Mary P. Bronner , David R. Byrd , Rodger C. Haggitt , and Michael B. Kimmey Metrics 7 March 2000Volume 132, Issue 5Page: 419KeywordsCarcinoma in situDysplasia ePublished: 15 August 2000 Issue Published: 7 March 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Die Bluttransfusion in Theorie und Praxis.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatology Highlights
Authors: Omar Y. Mousa, Harmeet Malhi, Nicholas Russo, Arun Jesudian, Joseph F. Pisa, Tasha B. Kulai, Jessica L. Maiers, Enis Kostallari, Nidhi Jalan‐Sakrikar, Zaid H. Tafesh, Brett E. Fortune, Lauren Yang, Daryl T.Y. Lau, Kavitha Nair, Joel Wedd
Journal: Hepatology (2019)

Mousa, Omar Y.1; Malhi, Harmeet1; Russo, Nicholas; Jesudian, Arun2; Pisa, Joseph F.; Kulai, Tasha B.1; Maiers, Jessica L.1; Kostallari, Enis1; Jalan‐Sakrikar, Nidhi1; Tafesh, Zaid H.†; Fortune, Brett E.2; Yang, Lauren‡; Lau, Daryl T.Y.3; Nair, Kavitha§; Wedd, Joel4Editor(s): Brown, Robert S. Jr.2,5; Schwartz, Robert E.2,5 Author Information
LEGISLATIVE BODIES AND SCHOOLS OF MEDICINE.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Children and sport
Authors: H. Crombie
Journal: BMJ (1996)

Epley's procedure should be used to treat benign positional vertigo EDITOR,-In response to our review on the'.treatment of benign positional vertigo' Graeme M Weiner advocates Cawthorne-Cooksey exercises as the superior choice for this condition.2We are aware that this reflects widespread practice in Brit- ain, but the published evidence justifying it is weak.Cawthorne-Cooksey exercises were devised to promote central compensation of stable unilateral vestibular deficits, and they serve this purpose well.Only one study, however, has evaluated the efficacy of such exercises for benign positional vertigo; it found that 32% of patients were cured after one week.3This compares unfavourably with the 60-80% rate of immediate success after just one application of Epley's procedure as shown in several open studies cited in our review.The efficacy of this technique, which aims to clear the posterior semicircular canal ofmobile particles, has been substantiated further by two recent studies.4'Patients appreciate the physician's support through a quick and effective manoeuvre as an alternative to repeated self inflicted attacks of the condition as occur with Cawthorne-Cooksey exercises.The 20% of patients who experience frequent recur- rences can be taught an adapted version of Epley's procedure for self treatment at home.We would invite Weiner to try Epley's manoeuvre himself because it was the grateful response of patients that ultimately defeated our initial scepticism.
Response: Re: Declines in Invasive Breast Cancer and Use of Postmenopausal Hormone Therapy in a Screening Mammography Population
Authors: K. Kerlikowske, D. S. M. Buist, R. Walker
Journal: JNCI Journal of the National Cancer Institute (2007)

Kerlikowske et al. ( 1 ) suggest that decreased use of hormone replacement therapy (HRT) led to decreased breast cancer incidence in a mammographically screened study population.Using sophisticated modeling techniques, the authors were able to show statistical significance in changing HRT and breast cancer diagnosis rates.However, the clinical conclusions reached
Intensive respiratory care unit. Review of ten years' experience
Authors: T. L. Petty
Journal: JAMA (1975)

In ten years' experience in the respiratory care units serving both medical and surgical patients, 18,077 consecutive patients received ventilatory support for 24 hours or more. The overall survival rate including all patients was 75.2%. Survival rate has not changed appreciably during the past five years. The respiratory care unit provides technical assistance and consultation to primary physicians of the medical and surgical services. This system of intensive respiratory care is flexible and applicable to general hospitals that treat large numbers of patients with acute respiratory failure. (<i>JAMA</i>233:34-37, 1975)
Giardiasis
Authors: Martin S. Wolfe
Journal: New England Journal of Medicine (1978)

MUCH publicity has been given to the epidemic incidence of giardiasis in travelers returned from the Soviet Union, and a number of water-borne outbreaks have occurred in the United States. Nevertheless, giardiasis remains an enigmatic infection.EpidemiologyTap water has been implicated as the main source of infection in Leningrad, but infections from other sources and in other parts of the Soviet Union certainly occur. However, giardiasis is not limited to the Soviet Union, and I have recognized infections contracted in 97 different countries. Areas of increased risk of infection for both longer-term residents and travelers in a series of . . .