tbuckley/cabot-search huggingface dataset:
Occupational and Related Dermatoses. Abstracts from the Literature for the Years 1935 to 1939, Inclusive
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurological Surgery
Authors: Robert H. Wilkins
Journal: JAMA (1994)

Stereotactic techniques are being applied increasingly in open cranial operations to improve the accuracy of the approach to intracranial targets. At the same time, there is more use of anatomic information from preoperative magnetic resonance imaging, especially surface imaging, and of functional information from techniques such as magnetoencephalography, positron emission tomography, and somatosensory evoked potential testing.<sup>1,2</sup>(Magnetoencephalography is a noninvasive method of monitoring the spatial and temporal pattern of neurophysiological activity within the brain; unlike electroencephalography, which measures electrical activity within the brain, magnetoencephalography measures the magnetic fields caused by such electrical activity.) The combination of such anatomic and functional data helps the surgeon plan the least harmful trajectory to the patient's lesion, with avoidance of injury to cortical areas that are important for movement, sensation, and speech. The use of endoscopic techniques in neurosurgery dates back to 1910 when a urologist named L'Espinasse used a cystoscope to fulgurate
FLECHSIG'S TREATMENT OF EPILEPSY.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A case of haemolytic uraemic syndrome. Demonstration at the Royal College of Physicians of London.
Journal: BMJ (1979)

FIG I-hest radiograph showing enlarged heart and fullness of vasculature in upper lobes.gram and echoencephalogram were normal.A lumbar puncture was normal with a pressure of 75 mm fluid.Her blood pressure was controlled with diazoxide and hydrallazine.Recurrent fits were controlled with diazepam.Three days later she was still unconscious and being treated with peritoneal dialysis.She suffered a respiratory arrest during a seizure and was given extemal cardiac massage.Her cardiac output and breathing quickly returned.Her haemoglobin was normal when she was first admitted to the obstetric hospital three weeks after delivery.Two days after
Determining educational needs in the physician's office
Authors: P. R. Manning
Journal: JAMA (1980)

Techniques to identify educational needs from real events in office practice are usually unwieldy, intrusive, and expensive. We are developing an approach based on review and analysis of individual physicians' prescriptions. This technique imposes little additional effort on the participating physician, yet effectively identifies problems in drug prescribing that can lead to specific educational remedies. Experience with 44 physicians using the system shows wide variation in prescribing practices as well as in the needs identified. The problems can be grouped into seven major categories: inappropriate indications; excessively frequent prescriptions for certain drugs; prescription of drugs with abuse potential; inadequate instructions; excessive dosage, especially in elderly patients; prescription of ineffective drugs; and potential drug interactions. The method offers promise as a component of an individualized guidance system linking continuing medical education with actual medical practice. (<i>JAMA</i>244:1112-1115, 1980)
Abstract SY37-03: Clock-HIF signaling in the epigenetic control of glucose metabolism
Authors: Clara Bien Peek
Journal: Cancer Research (2019)

Abstract Circadian systems play a central role in energy harvesting and storage across daily cycles of fuel availability. In vertebrates, clock genes promote metabolic constancy by coordinating the phase and expression of genes involved in glycolytic and oxidative metabolism. Our previous studies, as well as those from others, revealed that circadian transcription factors (TFs) display functional interactions with the hypoxia-inducible factor (HIF) pathway. Our previous studies demonstrated impaired hypoxic expression of known canonical HIF target genes in Bmal1-/- myotubes and fibroblasts, including those involved in anaerobic glycolysis, angiogenesis, and the HIF pathway. We also observed time-of-day-dependent activation of HIF targets in muscle tissue, raising the possibility that the clock acts to ‘gate’ the induction of HIF targets at different circadian phases. Moreover, we found that hypoxia and HIF can reciprocally regulate direct BMAL1 targets, suggesting a close association between hypoxic and circadian transcriptional networks. Finally, transcriptome profiling studies reveal strikingly little overlap in the subset of BMAL1-dependent genes in normoxia versus hypoxia, suggesting either global remodeling of ‘accessible’ chromatin at sites of promoters and enhancers allowing for altered BMAL1-dependent transcription. Collectively, our data reveal coupling of the HIF and circadian TF pathways producing rhythmic adaptation to hypoxic stress. Citation Format: Clara Bien Peek. Clock-HIF signaling in the epigenetic control of glucose metabolism [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr SY37-03.
3-D thermal reconstruction of the atherosclerotic plaque. A new insight into plaque vulnerability by means of thermography and advanced computer algorithms Leonidas D. Diamantopoulos, Glenn Van Langenhove, Pim De Feyter, David Folley, Patrick W. Serruys. Interventional Cardiology Dept, THORAXCENTER, ROTTERDAM, The Netherlands
Journal: Journal of the American College of Cardiology (2001)
BLU-285, DCC-2618 Show Activity against GIST
Journal: Cancer Discovery (2017)

Tyrosine kinase inhibitors may initially control gastrointestinal stromal tumors, but most patients eventually experience disease progression due to activation loop mutations, which are resistant to approved drugs. However, phase I trials suggest that the cancer is sensitive to two new agents: BLU-285 and DCC-2618. In addition, liquid biopsies, which were used to follow patients during the trials, may be valuable tools in tracking disease progression and assessing tumor heterogeneity.
Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes*1
Authors: J KOCK
Journal: Hepatology (2003)

Adefovir dipivoxil and lamivudine are two safe and efficacious drugs licensed for the treatment of chronic hepatitis B virus (HBV) infection. Both drugs inhibit the viral polymerase, resulting in a profound suppression of virus production. Blocking the viral polymerase may also affect the initiation of HBV infection, because HBV virions harbor a partially double-stranded genome and productive infection requires completion of viral plus-strand DNA synthesis with subsequent formation of covalently closed circular DNA (cccDNA). To address this issue, we used primary hepatocytes from the tree shrew Tupaia belangeri that were recently shown to be susceptible to HBV infection. Treatment of cells with either drug partially inhibited initial HBV cccDNA formation. Adefovir was more effective than lamivudine, resulting in a 3-fold reduction of RNA synthesis and viral surface antigen production. However, prevention of initial cccDNA formation was incomplete even after combined treatment, whereas de novo synthesis of viral replicative intermediates was completely suppressed. A possible explanation for this observation is the genomic plus-strand gap of less than 200 bases in some virions, limiting the window for antiviral action. In conclusion, nucleos(t)ide analogues can target initial plus-strand DNA repair and reduce but not completely block HBV infection. (Hepatology 2003;38:1410-1418.)
The academic viability of family medicine. A triad of challenges
Authors: E. D. Pellegrino
Journal: JAMA (1978)

EVERY innovation in medical education must ultimately prove itself academically; that is, it must define and demonstrate clearly what it can contribute uniquely to teaching, the care of patients, and the work of colleagues. Family medicine, which has been established largely through forces external to academia, has yet to meet these sterner tests of longterm survival. The question for the decade immediately ahead is whether it can sustain its claim as an integral element in medical education. The record of innovations engrafted on the body of medical education is not encouraging. Rehabilitative medicine, community medicine, behavioral sciences, interdisciplinary teaching, three-year curricula—all enjoyed an initial vogue. After begrudging acceptance, they have, to various degrees, gradually been buffered, absorbed, curtailed, or rejected. All face a dubious future in the current conservative climate of medical schools. Like other innovations, academic family medicine arises from a perceived social need. But it cannot meet that
IS THE MODEL TENEMENT A FAILURE?
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A new focus on myopia
Authors: T. T. Norton
Journal: JAMA (1994)

In this issue ofTHE JOURNAL, Zadnik et al<sup>1</sup>report results from an ongoing longitudinal study of children in Orinda, Calif, on the important topic of how children's eyes become myopic. The need for basic studies like this one has become increasingly clear in the past decade. Despite the high incidence of myopia in the United States (25% of adults<sup>2</sup>), the higher and apparently increasing incidence in the Far East (upward of 70% of schoolchildren in Taiwan<sup>3</sup>), and the increased risk for loss of vision in myopic patients,<sup>4</sup>there have been only limited data on normal human ocular development in children aged 8 to 14 years (the ages when most myopia is first detected). The most recent edition of<i>Vision Research</i>—<i>A National Plan</i>,<sup>5</sup>published by the National Eye Institute, calls for increasing the base of information in this area, and this study begins
ONE HUNDRED MILLIMETERS OF WHAT?
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply:
Authors: Valérie Eschwège, Olivier Chazouillières, Annie Robert
Journal: Hepatology (2008)

We read with interest the comments from Dr. Tripodi on the editorial by Dr. Marlar1 that accompanied the 2 papers on the prothrombin time (PT) in liver diseases.2, 3 We agree that the implementation of the new international normalized ratio (INR) specific for liver diseases (INR"LD") will presumably take time and that it is important to work on the different solutions discussed. All the options, namely, specific international sensitivity index for liver diseases provided by manufacturers, certified reference preparation for local calibrations, or well-validated restricted list of recombinant reagent and coagulometers, will require a strong international collaboration between biologists, hepatologists, and industry. Anyway, we want to emphasize that, whatever the strategy adopted, the INR"LD" must be considered as a new parameter and that its appropriate weight as a variable in all the scores used in liver diseases have to be reassessed in clinical studies. For example, in the MELD (Model for End-stage Liver Disease) score, the relative weight of INR"LD" compared to those of creatinine and bilirubin would probably be higher than the one calculated for the INR obtained with undefined thromboplastins at the time of the score definition.4 Furthermore, we would like to add a comment on the so-called "pragmatic" option proposed by Dr. Tripodi, that is, the centralization of plasma samples in a restricted number of "reference" laboratories for the MELD score calculation. This strategy seems very difficult to implement on an international scale and does not provide the PT standardization needed also in general screening, diagnosis and monitoring of acute and chronic liver injury.5, 6 Valérie Eschwège*, Olivier Chazouillières , Annie Robert*, * Unité d'Hémostase, Université Pierre et Marie Curie-Paris 6, Paris, France, Service d'Hépatologie, AP-HP, Hôpital St Antoine, Université Pierre et Marie Curie-Paris 6, Paris, France.
"GINGER POISON"
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis
Authors: Min Huang, Sherven Sharma, Li X. Zhu, Michael P. Keane, Jie Luo, Ling Zhang, Marie D. Burdick, Ying Q. Lin, Mariam Dohadwala, Brian Gardner, Raj K. Batra, Robert M. Strieter, Steven M. Dubinett
Journal: Journal of Clinical Investigation (2002)

Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-γ–dependent and independent manner. Here, we have evaluated the antifibrotic therapeutic potential of IL-7 in both in vitro and in vivo pulmonary fibrosis models. IL-7 inhibited both TGF-β production and signaling in fibroblasts and required an intact JAK1/STAT1 signal transduction pathway. IL-7–mediated inhibition of TGF-β signaling was found to be associated with an increase in Smad7, a major inhibitory regulator in the SMAD family. In the presence of IL-7, Smad7 dominant negative fibroblasts restored TGF-β–induced collagen synthesis, indicating that an IL-7–mediated increase in Smad7 suppressed TGF-β signaling. Consistent with these in vitro findings, recombinant IL-7 decreased bleomycin-induced pulmonary fibrosis in vivo, independent of IFN-γ. The antifibrotic activities of IL-7 merit further basic and clinical investigation for the treatment of pulmonary fibrosis.
Shedding light on BASH: a novel experimental model of advanced liver damage
Authors: Raquel Benedé, Feifei Guo, Olga Estévez Vázquez, Marius Woitok, Kang Zheng, Iris Asensio, Ignacio Juárez Martín-Delgado, José Manuel Martín Villa, Javier Vaquero, Rafael Bañares, Christian Liedtke, Francisco Javier Cubero, Yulia Nevzorova
Journal: Journal of Hepatology (2020)
FcγRIIIa Gene Polymorphisms May Correlate with Response to Frontline R-CHOP Therapy for Diffuse Large B-Cell Lymphoma.
Authors: Dong Hwan Kim, Hee Du Jung, Sang Kyun Sohn, Je-Jung Lee, Deok-Hwan Yang, Yeon Hee Park, Young Rok Do, Ho Jin Shin, Myung Soo Hyun
Journal: Blood (2006)
Fulminant serum hepatitis and meningococcic meningitis
Authors: T. B. Tri
Journal: JAMA (1975)

A YOUNG soldier contracted concomitantly fulminant serum hepatitis and meningococcic meningitis. He recovered without sequelae. We could find no previous reports of these two diseases occurring concomitantly. We believe there may be a relationship between the two diseases. <h3>Report of a Case</h3> A 17-year-old basic trainee was admitted to the hospital Jan 13, 1973, complaining of fever and arthralgia. His temperature was 38.8 C (101.8 F) and he had a localized maculopapular rash over the ankles. The rash and the fever resolved over the next several days. On the fourth day, his bilirubin level rose to 5.9 mg/100 ml, alkaline phosphatase level to 340 milliunits per milliliter (mU/ml), lactic dehydrogenase level to 650 mU/ml, and serum glutamic oxaloacetic transaminase (SGOT) level to 1,450 mU/ml; the prothrombin time dropped to less than 10% of control, and the counterelectrophoresis test for hepatitis associated antigen (HAA) was positive. His temperature rose to 39.4
Control of Heme and Cytochrome P-450 Metabolism by Inorganic Metals, Organometals and Synthetic Metalloporphyrins
Authors: Attallah Kappas, George S. Drummond
Journal: Environmental Health Perspectives (1984)

The heme-cytochrome P-450 complexes represent sensitive metabolic systems for examining the biological impact of metals on important cellular functions. Many metals, both in the inorganic form and bound to organic moieties, potently induce heme oxygenase, the rate limiting enzyme of heme degradation. The resulting increase in the rate of heme breakdown is reflected in a marked depression of cellular cytochrome P-450 content and impairment of the oxidative metabolism of natural and foreign chemicals dependent on this hemeprotein. Organometal complexes do not mimic in all their aspects the actions of the inorganic elements which they contain. For example, organotins, in contrast to inorganic tin, produce a prolonged induction response of heme oxygenase in the liver but not in the kidney. Co-protoporphyrin is a much more potent inducer of heme oxygenase in liver than is inorganic cobalt; and Sn-protoporphyrin inhibits heme oxygenase activity nearly completely, whereas inorganic tin is a powerful inducer of the renal enzyme. Contrasting effects on heme metabolism exist as well within the metalloporphyrin species as demonstrated by the effects in vivo of Co-protoporphyrin and Sn-protoporphyrin on heme oxygenase activity; the former induces the enzyme whereas the latter potently inhibits it. In vitro, however, both compounds competitively inhibit heme oxidation activity. These differences, among others which characterize metal actions in vivo and in vitro attest to the importance of pharmacokinetic, adaptive and other host factors in defining the responses of the heme-cytochrome P-450 systems to the impact of metals in the whole animal.