tbuckley/cabot-search huggingface dataset:
Cholangiocarcinoma: Intraductal Sonography
Authors: Kazuo Inui, Hironao Miyoshi, Junji Yoshino
Journal: Liver Cancer (2009)

The recent development of magnetic reso nance cholangiopancreatography (MRCP) and multiple-detector-row computed tom ography (MD-CT) facilitate diagnosis of the obstruction site in patients with cholan-giocarcinoma. However, the extension of cholangiocarcinoma is still difficult to diag nose precisely. The correct diagnosis of cancer extension, especially invasion to the portal vein and pancreas, is necessary to decide the operative procedures for a complete resection. Intraductal ultrasonog-raphy (IDUS) has been reported by several authors, (Kuroiwa et al., 1998; Fujita et al., 1998; and Tamada et al., 2001a), as a reliable method for the evaluation of extra-hepatic cholangiocarcinoma and aiding in its accurate staging. We, Kanemaki et al. (1997) and Inui et al. (1998), reported on the usefulness of three-dimensional intraductal ultrasonography (3D-IDUS) as a compre hensive image display, and the instruments and processor systems of 3D-IDUS have been developed. In this chapter, we introduce the methodology of IDUS and 3D-IDUS for the diagnosis of cholangiocarcinoma.
Abstract 2621: OLIG2 regulates stem cell maintenance and cell cycle in glioma stem cells
Authors: Norihiko Saito, Nozomi Hirai, Kazuya Aoki, Satoshi Fujita, Haruo Nakayama, Morito Hayashi, Takatoshi Sakurai, Satoshi Iwabuchi
Journal: Cancer Research (2019)

Abstract The Cancer Genome Atlas project described a robust gene expression-based molecular classification of glioblastoma with the functional and biological significance of the subclasses yet to be determined. Here, we show that a comprehensive analysis of a panel of glioma initiating cell (GIC) lines can identify a group of stem cells with high OLIGg2 expression as in Proneural-like GBM subtype. In vitro differentiation studies showed that proneural GIC lines possess the potential to differentiate into astrocytic, neuronal, and oligodendrocytic lineages, whereas mesenchymal GICs exhibited limited potential for neural lineage differentiation following retinoic acid induction. A considerable decline of OLIG2 in proneural GIC lines was observed following retinoic acid treatment. We also showed that OLIG2 is a functional marker associated with cell proliferation in Olig2-high GIC lines. In addition, OLIG2 inhibiton disrupted cell-cycle control mechanism by decreasing CDK2 and CDK4 and elevating apoptosis-related molecules. Mechanistic investigations revealed molecular interactions between CDK2/CDK4 and OLIG2. Inhibition of CDK2/CDK4 activity disrupted OLIG2-CDK2/CDK4 interactions and attenuated OLIG2 protein stability. Further investigation on these mechanisms may lead to novel targeted therapy on GBMs with high OLIG2 expression. Citation Format: Norihiko Saito, Nozomi Hirai, Kazuya Aoki, Satoshi Fujita, Haruo Nakayama, Morito Hayashi, Takatoshi Sakurai, Satoshi Iwabuchi. OLIG2 regulates stem cell maintenance and cell cycle in glioma stem cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2621.
Clinicopathologic features and treatment outcomes of patients (pts) with HER2-positive (pos) adenocarcinomas (ACA) of the esophagus (E) and gastroesophageal junction (GEJ).
Authors: B. E. Phillips, R. R. Tubbs, T. W. Rice, L. A. Rybicki, T. Plesec, C. P. Rodriguez, G. M. Videtic, J. P. Saxton, D. I. Ives, D. J. Adelstein
Journal: Journal of Clinical Oncology (2011)

4046 Background: HER2 is overexpressed in 21% of gastric and 33% of GEJ ACA, and pts with advanced HER2pos disease survive longer after chemotherapy and trastuzumab than after chemotherapy alone. This retrospective analysis was undertaken to better define the clinicopathologic features and treatment outcomes in pts with HER2pos ACA of the E and GEJ. Methods: Between 11/99 and 7/06, 156 pts with T3 or N1 or M1a ACA of the E or GEJ were entered on one of two Cleveland Clinic trials. Induction chemoradiation, with 96 hour infusions of cisplatin (20 mg/m2/d) and fluorouracil (1,000 mg/m2/d) beginning on day 1 of radiation (30 Gy at 1.5 Gy bid), was followed by surgery and identical post-operative chemoradiation. 76 pts also received 2 years of oral gefitinib. Pathology was tested for HER2 by immunohistochemistry using PATHWAY anti-HER-2/neu 4B5 Rabbit Monoclonal Primary Antibody (Ventana, Tucson AZ) and in situ hybridization with the INFORM HER2 Dual ISH DNA Probe Cocktail assay (Ventana, Tucson AZ). Baseline characteristics and outcomes after treatment of the HER2pos and negative (neg) pts were compared. Results: Of the 156 pts, 136 pts had either initial biopsy or resection specimen available. HER2 was deemed pos if either was pos. Discordance between biopsy and resection was found in only 6/65 pts (9%). 32 pts (24%) were HER2pos; 27% of 82 pts with GEJ, and 19% of 54 pts with E tumors (p=0.31). There was no statistical difference between HER2pos and neg pts in age, gender, race, stage, or pathological response. The only difference was that HER2neg tumors were more likely poorly differentiated (p<0.001). Locoregional control, distant metastatic control, freedom from recurrence and overall survival were statistically the same in both the entire cohort, and in the gefitinib-treated subset. Conclusions: Except for tumor differentiation, HER2pos and neg pts with ACA of the E and GEJ do not differ in clinicopathologic characteristics and treatment outcomes. Given the demonstrated benefit of trastuzumab in HER2pos gastric cancer and the similar incidence of HER2 overexpression in the E and GEJ, further evaluation of HER2 directed therapy in this disease seems indicated.
Epidermolysis Bullosa Acquisita
Authors: Donald L. Trump
Journal: JAMA (1980)

EPIDERMOLYSIS bullosa acquisita (EBA) is a nonheritable, noninflammatory, subepidermal mechanobullous disease of adults, characterized by the appearance of cutaneous blisters and ulcers after minor trauma.<sup>1</sup>Epidermolysis bullosa acquisita occurred in an elderly woman as the initial manifestation of amyloidosis and multiple myeloma. <h3>Report of a Case</h3> An 81-year-old woman was admitted to The Johns Hopkins Hospital with fractures of the left humerus and left femur and denuded areas of skin in both axillae and over the left hip. For two years before admission, the patient had experienced easy bruising and fragile skin. Cutaneous blisters formed after minimal skin trauma, and with mild trauma, patches of skin were completely avulsed. There had been no infections in the areas of injured skin, and they healed normally. There was no family history of skin disease. On the evening of admission, the patient had risen from bed and fallen to the floor. She experienced
A Multi-Centre Cohort Study Evaluating the Role of Inflammatory Markers in Patient's Presenting With Acute Ureteric Colic (MIMIC)
Authors: T.T. Shah, A.O.' Keefe, C. Gao, T. Manning, A. Peacock, S. Cashman, A. Nambiar, B. Lamb, M. Cumberbatch, P. Erotocritou, R. Pickard, D. Smith, V. Kasivisvanathan
Journal: International Journal of Surgery (2017)
Author Name Misspelled and Data and Wording Errors
Journal: JAMA (2014)

Zudin A. Puthucheary, MRCP; Jaikitry Rawal, MRCS; Mark McPhail, PhD; Bronwen Connolly, BSc; Gamunu Ratnayake, MRCP; Pearl Chan, MBBS; Nicholas S. Hopkinson, PhD; Rahul Phadke, FRCPath; Tracy Dew, MSc; Paul S. Sidhu, PhD; Cristiana Velloso, PhD; John Seymour, PhD; Chibeza C. Agley, MSc; Anna Selby, PhD; Marie Limb, PhD; Lindsay M. Edwards, PhD; Kenneth Smith, PhD; Anthea Rowlerson, PhD; Michael John Rennie, PhD; John Moxham, PhD; Stephen D. R. Harridge, PhD; Nicholas Hart, PhD; Hugh E. Montgomery, MD
SOLITARY INGUINAL HERNIA OF AN OVARY
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interaction of rifampin and glucocorticoids. Adverse effect on renal allograft function
Authors: G. A. Buffington
Journal: JAMA (1976)

Three renal transplant patients experienced progressive loss of renal allograft function during rifampin treatment for<i>Mycobacterium tuberculosis</i>. Previous studies have shown that rifampin causes induction of enzymes in hepatic microsomes that increase the catabolism of glucocorticoids. Evidence is presented that in our patients, the loss of renal allograft function during rifampin therapy was the result of decreased glucocorticoid effect presumably related to increased catabolism of the glucocorticoid drug they received. Thus, the adverse effects of rifampin on renal transplant function might be overcome by increasing the dose of glucocorticoid drug. (<i>JAMA</i>236:1958-1960, 1976)
PANICKY SANITATION AGAIN.
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Technetium Tc 99m macroaggregated albumin lung scans. Use in chronic childhood asthma
Authors: J. S. Hyde
Journal: JAMA (1976)

Serial roentgenograms and technetium Tc 99m macroaggregated albumin lung scans were done simultaneously in 30 bronchodilator-dependent asthmatic children and young adults during both relative remission and attacks of status asthmaticus. When chest roentgenograms showed air trapping and increased peribronchial vascular markings associated with persistent perfusion defects, the children benefited from further laboratory studies and continuous comprehensive therapy. Serial scans provided information about underperfusion that was not discernible either by roentgenograms or by usual blood gas studies. Also, lung scans are easier to obtain in children with long-standing asthma than are detailed pulmonary tests. In our study, technetium Tc 99m macroaggregated albumin scans showed persistent regional perfusion defects in 20 children with chronic asthma during relative remission and exacerbations. (<i>JAMA</i>235:1125-1130, 1976)
Clinical Lectures on Nervous Diseases
Authors: A. H. Bennett
Journal: BMJ (1879)

OF the hundred cases of epilepsy under consideration, there was epilepsia gravior in 62; epilepsia mitior in IO; epilepsia gravior et mitior in 28.I.-EPILEPSIA GRAVIOR.Premonitory Symptoms.-Ofthe ninety cases in which epilepsia gravior was present, there were no premonitory symptoms in 31; pre-
Prospective, observational registry of branded imatinib and nilotinib exposure in pregnant women: Voluntary postauthorization safety study.
Authors: M. Juma, S. Ericson, D. F. Eng, A. Adeoye
Journal: Journal of Clinical Oncology (2011)

TPS205 Background: Family planning decisions for patients of child-bearing age are impacted by their cancer diagnosis. Imatinib and nilotinib are category D drugs (ie, demonstrated risk to the fetus; however, the benefits of therapy may outweigh the potential risk to the fetus). Limited data exist concerning the safety of these drugs during pregnancy and the consequences of interrupting treatment. The Registry does not recommend patients receiving imatinib or nilotinib become pregnant, but serves only to document exposures that occur, and to collect information on the pregnancy outcome, maternal course of disease, and infant follow-up. Methods: The registry intends to enroll 225 women (≥18 years) treated with branded-only imatinib and nilotinib within 6 months prior to or during pregnancy (generic imatinib and nilotinib reports are excluded). The schedule of visits and treatment are according to local standard of care. Women are divided into two cohorts: 1) pregnancy/fetal: received tyrosine kinase inhibitors (TKIs) within 14 days of conception or at any time during pregnancy; 2) interrupted TKI: received TKIs within 6 months prior to conception but interrupted TKIs in preparation for/as a result of pregnancy. To identify signals of teratogenicity, the registry uses a general population baseline rate of birth defects, and the prevalence of defects in cohorts 1 and 2 may be compared. Cases will be quantitatively analyzed for the emergence of unique or patterns of defects. The primary objective is to monitor TKI-exposed pregnancies to estimate the prevalence of birth defects (calculated by dividing number of birth defects by total number of exposed live births from cohort 1. The secondary objectives are to: 1) determine the impact of treatment interruption on maternal disease status; 2) to assess and estimate the prevalence of serious adverse pregnancy outcomes; 3) and to assess and estimate the prevalence of developmental delays and functional deficits among infants during the first year of life. Maternal disease status is analyzed comparing disease status at registration, pregnancy outcome, and 1-year after birth, stratified by length of TKI interruption.
Abstract 71: NEDD8-activating enzyme inhibitor MLN4924 reduces cell viability and induces apoptosis in chemoresistant cancer stem-like cells of human urothelial carcinomas <i>in vitro</i> and <i>in vivo</i>
Authors: Shih-Ming Liao, Fu-Shun Hsu, Shao-Ping Yang, Yu-Wei Chang, Po-Ming Chow, Yeong-Shiau Pu, Yu-Chieh Tsai, Kuan-Lin Kuo, Kuo-How Huang
Journal: Cancer Research (2019)

Abstract Emerging evidence indicates that cancer stem cells (CSCs) may play a crucial role in cancer tumorigenesis, metastasis, and drug resistance. To develop treatment to inhibit CSCs provides promising target for cancer therapy. In this study, we identified a subpopulation of chemoresistant cancer stem-like cells of UCs (T24/R) after chemotherapeutic drug selection from T24, a bladder UC cell line. The T24/R cells displayed stemness markers (SOX2, Nanog, and Kruppel-like factor 4), high tumorigenicity in vivo, and enhanced invasion ability because of their epithelial-mesenchymal transition (EMT) properties. A neddylation inhibitor, MLN4924, efficiently inhibited viability and migration as well as induced apoptosis in the T24/R cells with concomitant suppression of stemness and EMT markers. Our findings suggest that MLN4924 effeiciently suppressed chemoresistant cancer stem-like UC cells and was a promising agent to conquer drug resistance in human bladder UCs. Citation Format: Shih-Ming Liao, Fu-Shun Hsu, Shao-Ping Yang, Yu-Wei Chang, Po-Ming Chow, Yeong-Shiau Pu, Yu-Chieh Tsai, Kuan-Lin Kuo, Kuo-How Huang. NEDD8-activating enzyme inhibitor MLN4924 reduces cell viability and induces apoptosis in chemoresistant cancer stem-like cells of human urothelial carcinomas in vitro and in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 71.
Effector and Regulatory Mechanisms in Immunity to Schistosomes: A Heuristic View
Authors: A Capron
Journal: Annual Review of Immunology (1985)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Treating cancer with coffee enemas and diet
Authors: B. T. Brown
Journal: JAMA (1993)

<h3>In Reply.</h3> —The American Medical Association Council on Scientific Affairs agrees with Dr McLellan that many patients with symptoms and a medical history suggestive of a multiple chemical sensitivity (MCS)—related syndrome are not helped by traditional medicine. We dispute his assertion that the clinical ecology report is insensitive to the suffering of patients with CFS, SBS, or any other MCS-related illnesses. The large body of anecdotal evidence supporting the validity of various hypotheses as the cause of MCS-related syndromes, or the value of suggested therapies, is impressive. However, the history of medicine is filled with numerous examples in which anecdotal evidence was widely accepted as proof of hypotheses for the cause of disease or as support for the value of therapies for a specific disease; when it became possible to carry out controlled studies, the validity of these hypotheses or therapies could not be demonstrated. The Council on Scientific Affairs
<i>The Institutional Care of the Insane in the United States and Canada</i>. By Henry M. Hurd, William F. Drewry, Richard Dewey, Charles W. Pilgram and T. J. W. Burgess. Edited by Henry M. Hurd, M. D., LL. D. Volumes I and II. (<i>Baltimore, Md.: The Johns Hopkins Press, 1916</i>.)
Journal: American Journal of Psychiatry (1916)
Cold Survival
Authors: D. E. M. Taylor
Journal: British Journal of Sports Medicine (1972)

The basic consideration in survival in Scotland whether under mountain or water conditions is the same, an inability to maintain the body temperature.This occurs where the losses of heat are greater than the heat produced by body energy (metabolism).With cold water immersion or wet through clothing, a low temperature and a high wind velocity on mountains, this can occur even at high levels of activity, but usually danger only occurs when body energy production falls with the onset of physical exhaustion.Therefore, exposure is now more correctly referred to as the exhaustion/exposure syndrome.The main danger with a fall in body temperature (hypothermia) accompanying exhaustion/exposure is its insidious onset, for patients do not collapse until their body temperature has already dropped about 50 C and is over half way to the level at which death usually occurs.The methods of heat loss by the body are by conduction, convection, radiation and evaporation.All of these are minimised principally by clothing in cold environments and are increased by lowering of the temperature of surroundings,the velocity of the air or water and soaking or water-losging of clothing.Death from hypothermia usually occurs when body temperature falls to between 26 and 300 C (normal 370 C) and is commonly due to arrest of the circulation.Three physical methods exist for heat loss copyright.
Correction
Authors: H Forces Appointments, Camberley Leslie
Journal: BMJ (1943)

First Things First SIR,-The majority of doctors must have been very worried for some time past by the revolutionary changes which are proposed for their Frofession, and I am sure that, like myself, they must have felt a new ray of hope when they listened to Mr. Churchill's broadcast speech on March 21.He said, " Don't take your eye off the ball for a moment."What is our ball?Surely, it must be the care of our fighting men by those doctors in the fighting Forces, and the care of the workers at home by the civilian doctors.These two essential tasks are already straining the medical profession to the utmost limits, and when there is a second front they will be strained even further.I think, therefore, that this comprehensive medical service should wait until Mr. Churchill's Four Years' Plan after victory has been won.At the end of his speech Mr. Churchill exhorted us to "act with comradeship and loyalty to our country and to one another" and "to make State enterprise and free enterprise both serve national interests and pull the National wagon side by side."After that, I think, there is no further need to discuss Assumption R. -I am, etc.,
Thyroid carcinoma after radiation therapy for adolescent acne vulgaris
Authors: E. C. Albright
Journal: JAMA (1967)

ROENTGEN THERAPY has been used for many years in patients with adolescent acne vulgaris. Without proper shielding of the neck the thyroid gland may receive undetermined amounts of irradiation. The potential carcinogenic effect on the thyroid has largely been ignored by the therapist in this group of patients, although the association of thyroid cancer and irradiation to the thymus in infancy is well recognized. The purpose of this report is to call attention to the possible hazard of thyroid cancer after radiation therapy for acne vulgaris. <h3>Report of Cases</h3> Five adult patients with thyroid cancer, in whom it was possible to obtain a history of radiation therapy for acne vulgaris in adolescence, have been seen. <h3>Case 1 (UH 267437).—</h3> A 24-year-old woman was admitted in October 1949 because of progressive, painless swelling in the right side of the neck for eight months. She had noted slight dysphagia for two weeks.
Variation in Taste Thresholds With Human Aging
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal