tbuckley/cabot-search huggingface dataset:
THE USE OF AN AGAR AGAR SOLUTION IN GASTROINTESTINAL ROENTGEN-RAY WORK
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Croonian Lectures on the Progress of Discovery Relating to the Origin and Nature of Infectious Diseases
Authors: J. B. Sanderson
Journal: BMJ (1891)

PVroduction of Inflarntnation by Chemical Irritants; Councilman's E.periiments: Scheuerlen's E,perimzents.-Production of In/lammation by the Chemical Products of Miicrophytes.-Leucoc.ytesandl the Chemical Norce produced by Phloyoyenic Microphytes; (Chimiota.ctis.-Met,chsics<koff'sTheory of Phayocytosis.-ItsAp- plication to the Platholog,y of _E'r,-ysipelas.Is Inclusion in a Leucocqyte an Invariable Antecedent oj the Death of the Miicro-])hyte?-/E,ffect of Le7ucocytes on the Multiplication of Micro- phytes.-Destiny of Microphytes in Susceltible and Insusceptible Animals.-Views of Hess and Bouchard.-"Aggravation " and " Attenuation."
Highlights
Journal: JAMA Pediatrics (2014)

The most cost-effective method for identifying children at risk for renal scarring is still debated.In this meta-analysis, Shaikh and colleagues pool individual patient data from 9 cohort studies to model predictors of the 16% of children who develop renal scars.A model that included temperature of at least 39°C, etiologic organism other than Escherichia coli, and abnormal ultrasonographic findings was only 3% to 5% less predictive than models requiring a blood draw of a voiding cystourethrogram.The editorial by Roberts discusses that renal damage matters more than reflux found on a voiding cystourethrogram.
Ethics of HIV trials
Authors: Peter Aaby, Abdel Babiker, Janet Darbyshire, Andrew Nunn, Sandhi Barreto, Pedro Alonso, Roberto Badaro, Fernando Barms, Cesar Victoria, Fred Binka, Benon Biryahwaho, Charles Byabainazima, Sylvester Sempala, Benon Tuguine, Pontiano Kalebu, Jane Kengeya-Kayondo, Jimmy Whitworth, Lynn Paxton, Jacinto Convit, Tumani Corrah, Keith McAdam, Manjula Datta, Yahya Dowlati, Paul Fine, Andy Hall, Richard Hayes, Shabbar Jaffar, David Ross, Peter Smith, Andreas de Francisco, Tore Godal, Jacob John, Mary Ann Lansang, Tessa Tan-Torres, Richard Morrow, Angus Nicoll, Catherine Peckham, David Serwadda, Marcel Tanner
Journal: The Lancet (1997)
Fertilization, embryo transfer procedures raise many questions
Authors: J. F. Henahan
Journal: JAMA (1984)

Since 1978, when Patrick Steptoe, MB, of Bourne Hall, Cambridge University, England, assisted at the birth of Louise Brown, in vitro fertilization procedures have been widely accepted throughout the world. Babies conceived by in vitro fertilization techniques now enter the world on a daily basis. It is estimated that, by the end of 1984, more than 1,000 births will be attributed to in vitro fertilization and embryo transfer techniques developed by Steptoe and his long-time Cambridge associate, Robert Edwards, MB. From the list of participants at the recent Third World Congress of In Vitro Fertilization and Embryo Transfer in Helsinki, it appears that physicians and scientists in about 25 countries now have in vitro fertilization programs under way. These countries include the United States, United Kingdom, Australia, France, East and West Germany, Denmark, Sweden, Finland, Italy, Switzerland, Belgium, Canada, New Zealand, Israel, Colombia, Chile, Japan, Singapore, and People's Republic of
Influence of Bone Resorption on the Mobilization of Lead from Bone among Middle-Aged and Elderly Men: The Normative Aging Study
Authors: Shirng-Wern Tsaih, Susan Korrick, Joel Schwartz, Mei-Ling Ting Lee, Chitra Amarasiriwardena, Antonio Aro, David Sparrow, Howard Hu
Journal: Environmental Health Perspectives (2001)

Bone stores of lead accrued from environmental exposures and found in most of the general population have recently been linked to the development of hypertension, cognitive decrements, and adverse reproductive outcomes. The skeleton is the major endogenous source of lead in circulating blood, particularly under conditions of accelerated bone turnover and mineral loss, such as during pregnancy and in postmenopausal osteoporosis. We studied the influence of bone resorption rate on the release of lead from bone in 333 men, predominantly white, middle-aged and elderly (mostly retired) from the Boston area. We evaluated bone resorption by measuring cross-linked N-telopeptides of type I collagen (NTx) in 24-hr urine samples with an enzyme-linked immunosorbent assay. We used K-X-ray fluorescence to measure lead content in cortical (tibia) and trabecular (patella) bone; we used graphite furnace atomic absorption spectroscopy and inductively coupled plasma mass spectroscopy to measure lead in blood and urine, respectively. After adjustment for age and creatinine clearance, the positive relation of patella lead to urinary lead was stronger among subjects in the upper two NTx tertiles (beta for patella lead > or =0.015) than in the lowest NTx tertile (beta for patella lead = 0.008; overall p-value for interactions = 0.06). In contrast, we found no statistically significant influence of NTx tertile on the relationship of blood lead to urinary lead. As expected, the magnitude of the relationship of bone lead to urinary lead diminished after adjustment for blood lead. Nevertheless, the pattern of the relationships of bone lead to urinary lead across NTx tertiles remained unchanged. Furthermore, after adjustment for age, the relation of patella lead to blood lead was significantly stronger in the upper two NTx tertiles (beta for patella lead > or =0.125) than in the lowest NTx tertile (beta for patella lead = 0.072). The results provide evidence that bone resorption influences the release of bone lead stores (particularly patella lead) into the circulation.
PRACTICAL NOTES.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Digitalis—A Review of Current Knowledge
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Agricultural Health Study
Authors: Michael C. R. Alavanja, Dale P. Sandler, Suzanne B. McMaster, Shelia Hoar Zahm, Cheryl J. McDonnell, Charles F. Lynch, Margaret Pennybacker, Nathaniel Rothman, Mustafa Dosemeci, Andrew E. Bond, Aaron Blair
Journal: Environmental Health Perspectives (1996)

The Agricultural Health Study, a large prospective cohort study has been initiated in North Carolina and Iowa. The objectives of this study are to: 1) identify and quantify cancer risks among men, women, whites, and minorities associated with direct exposure to pesticides and other agricultural agents; 2) evaluate noncancer health risks including neurotoxicity reproductive effects, immunologic effects, nonmalignant respiratory disease, kidney disease, and growth and development among children; 3) evaluate disease risks among spouses and children of farmers that may arise from direct contact with pesticides and agricultural chemicals used in the home lawns and gardens, and from indirect contact, such as spray drift, laundering work clothes, or contaminated food or water; 4) assess current and past occupational and nonoccupational agricultural exposures using periodic interviews and environmental and biologic monitoring; 5) study the relationship between agricultural exposures, biomarkers of exposure, biologic effect, and genetic susceptibility factors relevant to carcinogenesis; and 6) identify and quantify cancer and other disease risks associated with lifestyle factors such as diet, cooking practices, physical activity, smoking and alcohol consumption, and hair dye use. In the first year of a 3-year enrollment period, 26,235 people have been enrolled in the study, including 19,776 registered pesticide applicators and 6,459 spouses of registered farmer applicators. It is estimated that when the total cohort is assembled in 1997 it will include approximately 75,000 adult study subjects. Farmers, the largest group of registered pesticide applicators comprise 77% of the target population enrolled in the study. This experience compares favorably with enrollment rates of previous prospective studies.
Abstract 2109: A novel role for <i>ESRP1</i> in regulating proliferation in therapy-resistant ER-positive breast cancer
Authors: Yesim Gökmen-Polar, Yuan Gu, Xiaoping Gu, Sunil S. Badve
Journal: Cancer Research (2019)

Abstract Epithelial Splicing Regulatory Protein 1 (ESRP1) is a key splicing factor that plays an important role in cancer. We have previously demonstrated that ESRP1 is associated with poor prognosis and tamoxifen resistance in human ER-positive (ER+) breast tumors. Knockdown of ESRP1 decreased the tumor growth in ER+ breast cancer models resistant to endocrine therapy. In this study, we explored the upstream/downstream regulatory mechanisms of ESRP1 in tamoxifen-resistant breast cancer using ESRP1 knockdown model. Probe based-Human Transcriptome Array 2.0 (HTA; Applied Biosystems/Thermo Fisher) was performed using RNAs from control and ESRP1 knockdown cells [tamoxifen-resistant LCC2 cells (2-control) versus LCC2 cells with ESRP1 knockdown (2C3)] in ER+ breast cancer. Transcriptome profiling of ESRP1 in 2C3 knockdown model revealed that CEBP gamma, a transcription factor belonging to the CCAAT/enhancer-binding protein (C/EBP) family, was significantly decreased in ESRP1 knockdown cells (p value=2.33E-06). The expression of other related proteins C/EBP family including C/EBP alpha, C/EBP beta, and C/EBP delta that form homodimers and heterodimers with each other was also assessed. In knockdown cells, C/EBP alpha was increased (p value=0.0022), while two different C/EBP beta transcripts were decreased (p values=0.0010 and 0.03, respectively). C/EBP delta expression was not significantly altered. Using a competitive promoter-binding transcription-factor assay, we measured the transcription activity of C/EBP gamma in the absence and presence of ESRP1 promoter DNA fragment. We identified strong binding of C/EBP gamma to ESRP1 promoter region indicating that it is upstream regulator of ESRP1. CEBP transcription factor family members are important regulators of proliferation via cyclin-dependent kinases (CDKs). We further demonstrated that CDK4/CDK6 inhibitor abemaciclib decreases the expression of ESRP1 and C/EBPG levels significantly (p values= 0.0009 and 0.0019, respectively). In conclusion, for the first time, we identify that C/EBP gamma upregulates ESRP1 expression, which further regulates proliferation through control of expression of CDKs. Citation Format: Yesim Gökmen-Polar, Yuan Gu, Xiaoping Gu, Sunil S. Badve. A novel role for ESRP1 in regulating proliferation in therapy-resistant ER-positive breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2109.
<i>Announcement</i>: Glaucoma Awareness Month — January 2016
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

January is Glaucoma Awareness Month, a time to encourage persons at risk for glaucoma to schedule a comprehensive, dilated eye exam to detect and manage glaucoma.CDC's Vision Health Initiative in the Division of Diabetes Translation has partnered with the National Eye Institute's National Eye Health Education Program to educate the public and raise awareness about glaucoma, its risk factors, and its prevention.Glaucoma affects the optic nerve in the back of the eye, and is one of the leading causes of preventable blindness (1).Glaucoma has no warning signs, and approximately 50% of persons with glaucoma are unaware that they have the disease; therefore, a comprehensive, dilated eye examination is important for early detection and timely treatment (2).In 2010, approximately 2.7 million persons in the United States aged ≥40 years had glaucoma; by 2050, this number is projected to increase to 5.5 million persons (3).Groups at high risk include non-Hispanic blacks aged >40 years, Hispanics, Asians, persons aged ≥60 years, and those who have diabetes or a family history of glaucoma (4).Glaucoma also is associated with an increased risk for falls, fall-related injuries, depression, and reduced overall health and quality of life (5-7).In addition to regular comprehensive, dilated eye examinations to detect and treat glaucoma, innovative communitybased interventions are proving successful in reaching populations at high risk (8).Additional information about activities to promote early detection and treatment of glaucoma is available (http://www.cdc.gov/visionhealth,https://nei.nih.gov/nehep/programs/glaucoma).
Membership of Committees on Education (as of July 1, 1994)
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cerebral blood volume in man. Computer analysis of a computerized brain scan
Authors: R. D. Penn
Journal: JAMA (1975)

Cerebral blood volume in man can be measured by subtracting computerized axial tomogram density measurements taken before from those taken after an intravascular marker is infused into the blood. The average blood volume is 3.0 ml/100 ml of brain tissue, with a range of 2.4 to 4.25. This method can be applied in studying cerebral pathologic conditions. Areas of cerebral edema, surrounding a tumor, have a decreased blood volume. (<i>JAMA</i>234:1154-1155, 1975)
Control of intractable abdominal bleeding by external counterpressure
Authors: R. Pelligra
Journal: JAMA (1979)

Pressure of 20 to 25 mm Hg circumferentially applied to the abdomen and legs for periods up to 48 hours is a safe, effective, and practical adjunct to standard medical and surgical techniques for controlling intra-abdominal hemorrhage. Pressure is distributed uniformly through the abdominal cavity and aids hemostasis by decreasing transmural pressure and blood flow in arteries and veins. Compression of the venous capacitance reservoir causes shunting of blood to vital organs above the diaphragm. The mechanism of action, optimal pressures, physiological effects, indications, contraindications, and possible harmful effects of circumferential pneumatic compression are discussed. (<i>JAMA</i>241:708-713, 1979)
Mycoplasma pneumoniae Pneumonia
Authors: Bryan P. Simmons
Journal: JAMA (1979)

PNEUMONIA and pulmonary embolism may present clinically in a similar fashion.<sup>1</sup>Hemoptysis, dyspnea, tachypnea, pleuritic chest pain, hypoxemia, respiratory alkalosis, and fever are features commonly seen in both diseases. Usually a careful history in combination with a chest roentgenogram and other clinical findings, including purulent sputum production, will allow differentiation. <i>Mycoplasma pneumoniae</i>infections in adults may have a variety of clinical presentations, including pneumonia.<sup>2</sup>Despite these protean manifestations, pleuritic chest pain and hemoptysis are distinctly unusual in<i>M pneumoniae</i>pneumonia.<sup>2,3</sup>A patient was believed to have had mycoplasmal pneumonia that closely mimicked the syndrome produced by pulmonary embolism <h3>Report of a Case</h3> A 58-year-old man was transferred to Hershey Medical Center, complaining of hemoptysis and pleuritic chest pain. He had been in good health until two weeks before his transfer, when he began having shaking chills, fevers, and sweats. He was admitted to another hospital three days later,
Precious Cargo
Authors: Kathie Kadri
Journal: Annals of Internal Medicine (2002)

On Being a Doctor20 August 2002Precious CargoKathie Kadri, MD, PharmDKathie Kadri, MD, PharmDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-4-200208200-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Infatuation. A feeling of such intensity that I recall being startled by it, and my life was not the same thereafter. It was 11 December 1979, just past dawn. He was across the room from me, in an incubator because of a difficult birth. He lay on his side, looking toward me, pensive, calm, with incredible, large dark eyes. The most beautiful newborn I had ever seen. I fell deeply in love. I would not again experience such feelings for any other child. Daniel was the first in many ways: first child of my brother, whose wife was my dear ... Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Kathie Kadri, MD, PharmD, 1126 Calico Avenue, Billings, MT 59105; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 August 2002Volume 137, Issue 4Page: 291-292KeywordsBirthBloodEmotionsFallsForecastingHeartIntelligenceShockSkullSuicide ePublished: 20 August 2002 Issue Published: 20 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
GERMOPHOBIA
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ciguatera Fish Poisoning—Texas, 1997
Journal: JAMA (1998)

On October 21, 1997, the Southeast Texas Poison Center was contacted by a local physician requesting information about treatment for crew members of a cargo ship docked in Freeport, Texas, who were ill with nausea, vomiting, diarrhea, and muscle weakness. This report summarizes an investigation of this outbreak by the Texas Department of Health (TDH), which indicated that 17 crew members experienced ciguatera fish poisoning resulting from eating a contaminated barracuda.