tbuckley/cabot-search huggingface dataset:
Oxalate Metabolism.
Authors: L. H. Smith
Journal: Annals of Internal Medicine (1963)

s1 April 1963Oxalate Metabolism.L. H. Smith Jr., M.D.L. H. Smith Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-743_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOxalate is one of the most common constituents of kidney stones. Ingested oxalate is poorly absorbed, the majority of that appearing in the urine representing a metabolically formed end-product. Primary hyperoxaluria is a rare but serious disorder in which there is overproduction of oxalate with recurrent nephrolithiasis, nephrocalcinosis, and, occasionally, widespread tissue deposition of calcium oxalate, termed oxalosis. Previous studies have demonstrated that glycine and ascorbic acid are oxalate precursors. Recent studies have shown impaired metabolism of glyoxylate-C14in hyperoxaluria with increased incorporation of the isotope into urinary oxalate and glycolate. Glycolic aciduria has been demonstrated as a biochemical manifestation... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: L. H. SmithJr., M.D.Affiliations: Boston, Mass. (BS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 743-743KeywordsCalciumGlycineKidney stonesUrine ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
RE: Estrogen Plus Progestin and Breast Cancer Incidence and Mortality in the Women's Health Initiative Observational Study
Authors: S. Shapiro, T. J. deVilliers, A. Pines, D. W. Sturdee, D. F. Archer, R. J. Baber, N. Panay, R. D. T. Farmer, J. C. Stevenson, A. O. Mueck, H. G. Burger, A. Gompel
Journal: JNCI Journal of the National Cancer Institute (2013)
Salmonella Serotype Montevideo Infections Associated With Chicks—Idaho, Washington, and Oregon, Spring 1995 and 1996
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lichen nitidus.*
Authors: H. W. Barber
Journal: British Journal of Dermatology (1926)

Journal Article Lichen nitidus. Get access H. W. Barber, F.R.C.P. H. W. Barber, F.R.C.P. Physician in Charge, Skin‐Department, Guy's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 38, Issue 4, 1 April 1926, Pages 143–156, https://doi.org/10.1111/j.1365-2133.1926.tb09985.x Published: 01 April 1926
Abstract P314: Higher C-Reactive Protein Levels Among Women with a History of Hypertensive Disorders of Pregnancy
Authors: Lauren J Tanz, Jennifer J Stuart, Eric B Rimm, Mary A Vadnais, Stacey A Missmer, Eileen N Hibert, Janet W Rich-Edwards
Journal: Circulation (2017)

Introduction: Women with a history of pregnancy complications, including hypertensive disorders of pregnancy (HDP: preeclampsia and gestational hypertension) and preterm delivery (&lt;37 weeks), have an increased risk of cardiovascular disease (CVD). There is limited knowledge of the pathway linking pregnancy outcomes and CVD, but chronic inflammation may play a role. Methods: We selected parous women from the Nurses’ Health Study II who had the inflammatory biomarkers C-reactive protein (CRP; n=2,987) or interleukin (IL)-6 (n=2,916) assessed in stored blood samples provided after pregnancy, between 1996 and 1999. Women were selected from previous nested case-control biomarker studies. Robust linear regression models were used to separately evaluate the mean differences in CRP and IL-6 and 95% confidence intervals (CIs) associated with a history of HDP compared to no such history and with a history of preterm delivery compared to no such history. Models were adjusted for age at blood draw, pre-pregnancy body mass index and smoking, and variables related to lab selection. Results: Ten percent (285 of 2,987) of women had a history of HDP, while 12% (358 of 2,987) had at least one preterm delivery prior to blood draw. Median time from first pregnancy to blood draw was 17 years (range: 1-37 years). Mean CRP levels were 2.00 mg/L and 1.57 mg/L, while mean IL-6 levels were 1.56 pg/mL and 1.42 pg/mL in women with and without a history of HDP, respectively. In women with and without preterm delivery, mean CRP levels were 1.54 mg/L and 1.62 mg/L and mean IL-6 levels were 1.39 pg/mL and 1.44 pg/mL, respectively. Plasma levels of CRP were 0.36 mg/L (95% CI: 0.12, 0.60) higher, on average, in women with a history of HDP compared to those with all normotensive pregnancies. Plasma IL-6 levels were not significantly higher among women with a history HDP (0.06 pg/mL, 95% CI: -0.16, 0.27). There were no significant differences in CRP (-0.11 mg/L, 95% CI: -0.30, 0.07) or IL-6 (-0.08 pg/mL, 95% CI: -0.25, 0.10) levels in women with a history of preterm delivery. Conclusion: CRP was elevated in women with a history of HDP in the decades following pregnancy, suggesting a potential inflammatory response. An altered inflammatory profile was not present in women with a history of preterm delivery. Further investigation is needed to confirm these inflammatory responses in women with a history of pregnancy complications and to evaluate the utility of CRP as a potential risk marker in CVD screening.
The Somatotrope as a Metabolic Sensor: Deletion of Leptin Receptors Causes Obesity
Authors: Gwen V. Childs, Noor Akhter, Anessa Haney, Mohsin Syed, Angela Odle, Michael Cozart, Zachary Brodrick, Dana Gaddy, Larry J. Suva, Nisreen Akel, Christopher Crane, Helen Benes, Amanda Charlesworth, Raul Luque, Streamson Chua, Rhonda D. Kineman
Journal: Endocrine Reviews (2010)

Leptin, the product of the Lep gene, reports levels of adiposity to the hypothalamus and other regulatory cells, including pituitary somatotropes, which secrete GH. Leptin deficiency is associated with a decline in somatotrope numbers and function, suggesting that leptin may be important in their maintenance. This hypothesis was tested in a new animal model in which exon 17 of the leptin receptor (Lepr) was selectively deleted in somatotropes by Cre-loxP technology. Organ genotyping confirmed the recombination of the floxed LepR allele only in the pituitary. Deletion mutant mice showed a 72% reduction in pituitary cells bearing leptin receptor (LEPR)-b, a 43% reduction in LEPR proteins and a 60% reduction in percentages of immunopositive GH cells, which correlated with reduced serum GH. In mutants, LEPR expression by other pituitary cells was like that of normal animals. Leptin stimulated phosphorylated Signal transducer and activator of transcription 3 expression in somatotropes from normal animals but not from mutants. Pituitary weights, cell numbers, IGF-I, and the timing of puberty were not different from control values. Growth curves were normal during the first 3 months. Deletion mutant mice became approximately 30-46% heavier than controls with age, which was attributed to an increase in fat mass, with no significant effects on lean mass. Serum leptin levels were either normal in younger animals or reflected the level of obesity in older animals. The specific ablation of the Lepr exon 17 gene in somatotropes resulted in GH deficiency with a consequential reduction in lipolytic activity normally maintained by GH and increased adiposity.
Intestinal Mucosal Mechanisms Controlling Iron Absorption
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dr. Remondelli Not a World War I Veteran.
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microbiology
Authors: Wesley White
Journal: JAMA (1990)

The authors describe this textbook of microbiology as "designed for medical students with a strong interest in science, as well as for graduate students and investigators." They are right on target. This remains the premier textbook of microbiology for students. It can be an excellent reference text for microbiologists and laboratory workers. The basic design has changed little since the 1980 edition. There are 65 chapters by 33 authors, divided among four major sections. The first is on bacterial physiology and genetics. This section shows the most reorganization and reworking. Advances in molecular genetics and gene regulation are clearly apparent. There are chapters on bacterial structure, growth, protein synthesis, DNA replication, and chemotherapy for infectious agents. Section 2 on immunology remains one of the strongest sections. It, along with the virology section, can be purchased separately as a paperback book. All aspects of the human immune response, including immunoglobulins, cell-mediated
Management of variceal haemorrhage in cirrhotic patients
Authors: A K BURROUGHS, D W PATCH
Journal: Gut (2001)

Editor,—We have serious concerns about several of the recent UK guidelines for the management of variceal haemorrhage in cirrhotic patients ( Gut 2000; 46 (suppl 3 and 4):iiiI–iii115), particularly those that contradict current published evidence. We highlight below the ones we feel are the most important. In the management of acute variceal bleeding, variceal ligation is not the method of first choice which was given an AI recommendation. Meta-analysis of all trials of acute bleeding of banding versus injection sclerotherapy have shown no statistically significant difference between the two treatments for either control of bleeding or survival (data derived from 12 studies with 419 patients), with no statistical heterogeneity.1 The implication of recommending ligation for acute bleeding is that double intubation would be necessary in a patient who is actively bleeding so as to attach the ligation device after the initial diagnostic endoscopy. Although there is no evidence, this would create more risk to the patient; it is common sense that a single intubation would be preferable and would take less time. At best the recommendation should be that either endoscopic technique could be used as first choice, dependent on operator expertise and facilities. Secondly, there is evidence from randomised studies of vasoactive drug therapy combined with endoscopic techniques that combination therapy is superior in terms of control of bleeding. This is based on five randomised studies with 610 patients (pooled odds ratio 0.42, 95% confidence interval 0.29–0.6).1 Publication bias assessment has shown that 29 null or negative studies would be needed to render the results non-significant, and thus this effect is fairly robust. Moreover, in several of these studies vasoactive drugs were given before diagnostic endoscopy, demonstrating their utility during the period of resuscitation before endoscopy could be safely performed, which in practice may be several … Dr R Jalan, Institute of Hepatology, University College London Medical School, 69–75 Chenies Mews, London WC1E 6HX, UK. r.jalan{at}ucl.ac.uk
THE DEATH RATE OF ST. LOUIS.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Coffee consumption, RF, and the risk of RA
Authors: D HUTCHINSON
Journal: Annals of the Rheumatic Diseases (2001)

We read with interest the paper entitled “Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis”,1 in which an association between coffee consumption and the presence of a positive rheumatoid factor (RF) in healthy subjects was reported. The authors also observed an increased risk of developing seropositive rheumatoid arthritis (RA), particularly in people who were lifelong non-smokers and drinking four cups of coffee or more. Cigarette smoking seemed to be the single most important risk factor for the development of a positive RF in healthy subjects and was strongly associated with coffee consumption. In view of this, however, it seems surprising that there is no additive risk noted for the development of seropositive RA in people who were heavy smokers and also habitual coffee drinkers. We suggest that the observed risk for developing seropositive RA in people who have never smoked and who consume more than four cups of coffee is possibly confounded by exposure to passive cigarette smoke. For example, coffee in Finland is often consumed in coffee houses, which are prone to be particularly smoky environments, and coffee drinkers are likely to … markku.heliovaara{at}ktl.fi
Predictors of a sustained beneficial response to interferon alfa therapy in chronic hepatitis C
Authors: Hari S. Conjeevaram, James E. Everhart, Jay H. Hoofnagle
Journal: Hepatology (1995)

Predictors of a Sustained Beneficial Response to InterferonAlfa Therapy in Chronic Hepatitis CInterferon alfa was first reported to have beneficial effects in chronic hepatitis C in the mid-l980s,' effects that were subsequently verified in multiple randomized controlled trials performed in many countries throughout the ~o r l d .~. ~ This agent was approved for use as therapy in chronic hepatitis C in 1991, the first and still the only approved therapy for a disease that accounts for at least 30% of chronic liver disease and cirrhosis in the United States.In the several years since the licensing of interferon alfa for chronic hepatitis C, the enthusiasm for this therapy has been tempered by experience.A high proportion of patients have improvements in serum aminotransferases, hepatitis C virus (HCV) RNA levels, and hepatic histology during therapy, but only a small percentage have a long-term beneficial response.6For instance, in a recent European multicenter trial using the standard regimen of interferon alfa recommended in the United States (3 million units thrice weekly for 6 months), the long-term response rate was only 14%.7In our own experience from the Clinical Center of the National Institutes of Health, only 11 of 59 treated patients (19%) maintained a sustained response when assessed 1 to 5 years after therapy.Thus, many patients are treated but few have a long-term benefit.Of course, if one could predict which patients would ultimately have a long-term beneficial response to interferon alfa therapy, one might treat only those whose likelihood of a response warranted the expense and discomforts of the 6 months of therapy.It is for this reason that clinical trials as well as most published large series of treatment usually include secondary analyses of predictive factors for a response; comparing the response to therapy according to pretreatment clinical, biochemical, histological, and virological features.Despite many differences in design of these studiesin types of interferon used, doses and drug regimens, patient populations, definitions of response, duration of follow-up, and serological and virological tests methods used-several predictive factors have been found repeatedly to be associated with a high likelihood of a Abbreviations: HCV, hepatitis C virus.
“Cure” of Rheumatism and Joint-Trouble
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ferdinand Sauerbruch
Authors: Frank B. Berry
Journal: JAMA (1964)

<h3>To the Editor:—</h3> I read with unusual interest your sketch of Ferdinand Sauerbruch (<i>JAMA</i><b>190</b>:152 [Oct 12] 1964). Unusual, because I knew him rather well from August, 1945, to January, 1946. In August, 1945, Dr. Edward D. Churchill (then Colonel Churchill) and I called on him shortly after General Clay had established his headquarters in Berlin. We had a very pleasant visit, and he was naturally very much pleased to see Pete Churchill. He was amazed at the progress that had been made in the treatment of tuberculosis with the various types of pulmonary resections, and he said that Germany had been cut off increasingly from foreign literature since the early thirties. He further told us that he and his wife—a Belorussian—had lived in the surgical "bunker" at the Charité during the last three weeks of the war, that Hitler had given orders to blow it up, but that
Rare Cases in Midwifery
Authors: E. Copeman
Journal: BMJ (1862)

THERE are two physical properties possessed by chloroform which, so far as I am aware, are not alluded to in any of our text books on materia medica; namely-I.Its solubility in alcohol, and subsequent miscibility in water; 2. Its miscibility, if not its solubility, in water.Lately, while engaged experimenting in order to ascertain the probable composition of Davenport's chlorodyne, I accidentally discovered the following valuable facts.1.If chloroform be dissolved in rectified spirit of wine, of specific gravity -838, at 600 Fahr.(L.P.), in the proportion of from one to sixteen minims of chloroform in a fluid-ounce, the resulting liquid is entirely and freely
A dispassionate view
Authors: R. B. Roth
Journal: JAMA (1971)

An abundance of time and talent has been devoted to the devising of remedies for our alleged "crisis" in the provision of medical services for our country. The resulting proposals have been characterized as a wondrous blend of politics, self-interest, and humanitarianism. "Personal Health Services Systems: Desiderata" (this issue p 1683) represents a calm, orderly presentation of the elements inherent in a desirable "system" as conceived by a responsible, scholarly authority in the field of medical care. It will be encouraging to those of a conservative stripe to know that Professor White endeavors to build on the strengths of our present accomplishments, and that he rejects the development of a national health service. They may, however, be unwilling to accept his belief that in this country the medical profession must either organize itself or be organized—at least in any peremptory fashion. Here, with some precision, is presented what may well