tbuckley/cabot-search huggingface dataset:
Vulvovaginal candidiasis
Authors: C M Bates, S M Sawyer, G Bowes, P D Phelan
Journal: BMJ (1994)

patients with recurrent unexplained falls and syncope, and 82% of this group benefit from intervention.2Simple faints are uncommon in elderly people, partly because of their altered baroreflex sensitivity.Treatment with a vasodilator is the commonest cause of vasovagal syncope, and symptoms may be modified or abolished by a change in treatment.If carotid sinus massage produces an important reproducible asystolic response this is not normal5 and in symptomatic patients requires physiological pacing to abort recurrent syMptoms.4Slowing of the heart rate of greater than 3 seconds during carotid sinus massage does not occur in asymptomatic elderly people.5The carotid sinus syndrome is an underdiagnosed cause of dizziness, falls, and syncope,3 and cardiac pacing will abort syncopal episodes in most cases, although dizziness may persist because ofpersistent hypotensive features.4
23. From stealthy, controlled release polymersomes to cylinder-shaped ‘filomicelles’ for imaging and delivery
Authors: Nicholas A. Peppas, Ruth Duncan, Gary E. Wnek, Allan S. Hoffman, Guang Hui Gao, Sung Wan Kim, Doo Sung Lee, Michael Hadjiargyrou, Elka Touitou, Denize Ainbinder, Russell Mumper, Alain Rolland, Takuro Niidome, Vinod Labhasetwar, Shi Liu, Guangyuan Zhou, Yubin Huang, Zhigang Xie, Xiabin Jing, Noemi Csaba
Journal: Journal of Controlled Release (2014)
ORIGINAL INVESTIGATIONS ON THE NATURAL HISTORY, (SYMPTOMS AND PATHOLOGY) OF YELLOW FEVER. 1854-1894.
Authors: JOSEPH JONES
Journal: JAMA (1895)

<h3>CHAPTER X.</h3><h3>BLACK VOMIT OF YELLOW FEVER.</h3> The following observations on the black vomit of yellow fever, are the results of labors begun in 1856, and pursued, in various portions of the Southern States, up to the present time. I have shown, by numerous careful post-mortem examinations, and by analysis of the blood, black vomit, and urine during life, in various stages of the disease, that: During the active stages of yellow fever, profound changes take place in the organs and tissues, and especially in the kidneys, heart and liver; and oil and granular fibrinous or fibroid matters (altered albumin and fibrin), transude through the capillaries and fill up the cells and excretory ducts, and arrest or impair the functions of these organs. The liver of yellow fever does not present the soft friable condition characteristic of true fatty degeneration. The jaundice resulting from the suppression of the excretory function
β-Arrestin-2 regulates the development of allergic asthma
Authors: Julia K.L. Walker, Alan M. Fong, Barbara L. Lawson, Jordan D. Savov, Dhavalkumar D. Patel, David A. Schwartz, Robert J. Lefkowitz
Journal: Journal of Clinical Investigation (2003)

Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function and is regulated in large part by chemokine receptors, members of the seven-membrane-spanning receptor family. It has been reported recently that T cells lacking β-arrestin-2, a G protein–coupled receptor regulatory protein, demonstrate impaired migration in vitro. Here we show that allergen-sensitized mice having a targeted deletion of the β-arrestin-2 gene do not accumulate T lymphocytes in their airways, nor do they demonstrate other physiological and inflammatory features characteristic of asthma. In contrast, the airway inflammatory response to LPS, an event not coordinated by Th2 cells, is fully functional in mice lacking β-arrestin-2. β-arrestin-2–deficient mice demonstrate OVA-specific IgE responses, but have defective macrophage-derived chemokine–mediated CD4+ T cell migration to the lung. This report provides the first evidence that β-arrestin-2 is required for the manifestation of allergic asthma. Because β-arrestin-2 regulates the development of allergic inflammation at a proximal step in the inflammatory cascade, novel therapies focused on this protein may prove useful in the treatment of asthma.
Benign transient eosinophilia following intravenous urography
Authors: M. E. Vincent
Journal: JAMA (1977)

Eosinophilia, a component of the allergic response, may occur after the use of iodinated radiographic contrast media for intravenous urography. A benign transient elevation in differential eosinophil count was seen in 21 of 101 patients following the injection of iodinated contrast agents for that purpose. (<i>JAMA</i>237:2629, 1977)
LAW &amp;amp; MEDICINE
Authors: Angela Roddey Holder
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The National Cancer for Health Care Technology
Authors: S. Perry
Journal: JAMA (1981)

THE NATIONAL Center for Health Care Technology (NCHCT) was established by an act of Congress (Public Law 95-623) to provide a forum for the assessment of health care technologies. It is responsible for undertaking and supporting research and for synthesizing the results of such research to offer providers, consumers, industry, and government agencies concerned with health reliable and broadly derived information on which to base their decisions. The Center is not a regulatory agency, and it is not intended necessarily to be a vehicle for cost containment. The initiation of a feature inThe Journal, NCHCT UPDATE, will greatly enhance information dissemination activities of the Center. This article describes the mandate to the Center, its history, its operating guidelines, and its activities to date. Future articles will contain reports of the scientific basis for Medicare coverage decisions, summaries of the findings of technology assessment forums, and descriptions of research activities.
Abstract B30: High-throughput, purification-free, multiplexed profiling of circulating miRNA for discovery, validation, and diagnostics
Authors: Isaac Stoner, Michael Tackett, Conor Rafferty, Andreas Windemuth, Elnaz Atabakhsh, Jessica Tytell, Daniel Pregibon
Journal: Cancer Research (2016)

Abstract To address the needs for circulating miRNA biomarker validation, we developed the Multiplexed Circulating microRNA assay. This assay enables the detection of up to 68 microRNA targets per sample in 96-well format with readout on standard flow cytometers and analysis with an included bioinformatics software package. The Circulating microRNA assay combines particle¬-based multiplexing, using patented Firefly hydrogel particles, with single¬ step RT-PCR signal amplification using universal primers. Thus, the Circulating microRNA assay leverages PCR sensitivity while eliminating the need for separate reverse transcription reactions and mitigating amplification biases introduced by target¬-specific qPCR. Furthermore, the ability to multiplex targets in each well eliminates the need to split valuable samples into multiple reactions. Results from the Circulating microRNA assay are displayed and interpreted using our included Firefly Analysis Workbench, which allows visualization, normalization, and export of experimental data with only a few mouse clicks. To aid discovery and validation of biomarkers, we have generated fixed panels for Oncology, Cardiology, Neurology, Immunology, and Liver Toxicology. These carefully curated panels include hemolysis markers to assess sample quality, as well as critical normalization factors. Here we present the data from several studies investigating circulating and tumor microRNA profiles using the Firefly Circulating microRNA Assay Fixed Panels. Together, this novel combination of bioinformatics tools and multiplexed, high¬-sensitivity assays enables rapid discovery and validation of microRNA biomarker signatures from fluid specimens. Citation Format: Isaac Stoner, Michael Tackett, Conor Rafferty, Andreas Windemuth, Elnaz Atabakhsh, Jessica Tytell, Daniel Pregibon. High-throughput, purification-free, multiplexed profiling of circulating miRNA for discovery, validation, and diagnostics. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr B30.
Abstract 3309: Healthcare resource utilization in follicular lymphoma patients treated with maintenance rituximab in the Veterans Health Administration
Authors: Ahmad S. Halwani, Catherine Li, Kelli M. Rasmussen, Vikas Patil, Christina Yong, Zachary Burningham, Brian C. Sauer
Journal: Cancer Research (2019)

Abstract OBJECTIVES: Examine healthcare resource utilization (HCRU) in follicular lymphoma (FL) patients treated with or without maintenance rituximab (MR). METHODS: FL patients treated in the Veterans Health Administration (VHA) between 2006-2014 were identified by linking information from the VA Cancer Registry System (VACRS) and the Corporate Data Warehouse. HCRU was defined as the total number of outpatient visits (OPV), inpatient visits (IPV), and the number of emergency department visits (EDV) during follow-up time, which was approximately four years. To avoid immortal time bias, a prescription time distribution matching method was performed, followed by an inverse probability weighted regression analysis to account for variation in the follow-up period. The observational period was partitioned into four-yearly intervals. The observed HCRU value was weighted by the inverse of the probability of not being censored by the end of the yearly interval. A generalized linear model with Poisson distribution and log link was performed for each of the four intervals while adjusting for the covariates. Using a 95% bootstrap confidence interval, the change of HCRU was summed across the four-yearly intervals to obtain the cumulative change of HCRU between FL patients who received MR or did not receive MR. RESULTS: From 2006-2014, 2,290 FL patients were diagnosed at VHA. After excluding patients with a prior cancer, documented grade 3b or stage I disease, 905 MR-eligible patients remained, of which 319 (35%) received MR and 586 (65%) did not receive MR. When compared with non-MR patients, MR patients were slightly more likely to have a mean increase in OPV (0.69%; CI: 0.44%-0.94%) and a mean decrease in IPV (14.83%; CI: 16.09%-13.58%). There was no significant change in the number of EDV between the MR treated and non-MR treated patients. CONCLUSIONS: This nationwide real-world study suggests that on average FL patients treated with MR have fewer IPV and more OPV than non-MR patients. Note: This abstract was not presented at the meeting. Citation Format: Ahmad S. Halwani, Catherine Li, Kelli M. Rasmussen, Vikas Patil, Christina Yong, Zachary Burningham, Brian C. Sauer. Healthcare resource utilization in follicular lymphoma patients treated with maintenance rituximab in the Veterans Health Administration [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3309.
Incidence of parenchymal liver diseases in Denmark, 1981 to 1985: Analysis of hospitalization registry data
Authors: T Almdal
Journal: Hepatology (1991)

The sex-specific and age-specific incidence rates of the major parenchymal liver diseases in a North European population were estimated using a computerized registry of all admissions to somatic hospitals in Denmark. The incidence was calculated by counting all incident cases of these diseases reported to the registry in the 5-yr period 1981 to 1985 and dividing the number of cases by the number of person-years at risk in this period. The incidence rates (per million person-years) were for men and women, respectively: infectious hepatitis, 109 and 71; toxic hepatitis, 19 and 22; chronic hepatitis, 27 and 29; alcoholic cirrhosis, 190 and 85; nonalcoholic nonbiliary cirrhosis, 110 and 82; primary biliary cirrhosis, 4 and 14. The pattern of the age-specific incidence rates was similar in men and women in infectious hepatitis, alcoholic cirrhosis, nonalcoholic nonbiliary cirrhosis and primary biliary cirrhosis. Toxic and chronic hepatitis had a higher incidence in women than in men only in older age groups. The incidence of idiopathic hemochromatosis, Wilson's disease, secondary biliary cirrhosis, portal vein thrombosis and Budd-Chiari's syndrome were less than four in both sexes. (HEPATOLOGY 1991;13:650–655.)
Lines
Authors: Beatriz M. Rodriguez
Journal: Annals of Internal Medicine (2001)

Ad Libitum20 November 2001LinesBeatriz M. Rodriguez, MDBeatriz M. Rodriguez, MDRockford, IL 61103Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-10-200111200-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What of the day I look like those patients withering away in a bed, powerless, hair standing on end, in that permanent fuzz, so many wrinkles there are no features ... Author, Article, and Disclosure InformationAffiliations: Rockford, IL 61103Corresponding Author: Beatriz M. Rodriguez, MD, 2400 Rockton Avenue, Rockford, IL 61103. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 November 2001Volume 135, Issue 10Page: 925KeywordsAdolescentsBrainFearHeartInterleukinsSports ePublished: 20 November 2001 Issue Published: 20 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PARACENTESIS THORACIS: WHEN IS IT JUSTIFIABLE?
Authors: D. H. Tuke
Journal: BMJ (1855)

OURNAL_ 1109 tk_; biu Wo or three yellow spots, thewis of a pea, an mSusd oyer its surfaeo.She i recommended to keep attack and opertion was three months eight days ;* the pa-* This was not his own patient.He bha already beeu.
Drift
Authors: Malini M. Gandhi
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Topical agents alone in acne. A blind assessment study
Authors: L. J. Swinyer
Journal: JAMA (1980)

The comparative effectiveness of three comprehensive therapeutic programs was studied in 118 patients with mild to moderate acne vulgaris. A topical program of tretinoin, benzoyl peroxide, and water avoidance was found to be as effective as the more commonly employed program of systemic tetracycline therapy with topically applied tretinoin and better than a program using systemic tetracycline therapy with abradant cleansers. At 16 weeks of therapy for all groups, the degree of skin dryness correlated with lack of improvement. Skin dryness is established as an aggravating factor in both the pathogenesis and treatment of acne. The topical program was nonirritating, well accepted by patients, and less expensive than the other two regimens. (<i>JAMA</i>243:1640-1643, 1980)
Voices
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endocrine Receptors
Authors: G. I. M. Swyer
Journal: BMJ (1947)

remember rightly, gastroscopy has been reported as confirming this supposition.In view of the utter uselessness of all treatment up till now any therapeutic measure would be welcome.The peculiar sensi- tivity of the skin would suggest a trial of "' benadryl."This might be a valuable measure in those cases with feye lesions where any decrease of inflammation would mitigate the cumu- lative and recurrent damage to these organs.-Iam, etc., Oxford.
Angioplasty vs Bypass Surgery in Patients With Multivessel Coronary Artery Disease
Authors: Dilip B. Viswanath
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The Bypass Angioplasty Revascularization Investigation (BARI) Investigators<sup>1</sup>reported a greater need for additional revascularization procedures among patients who were initially randomized to percutaneous transluminal coronary angioplasty (PTCA[52%]), compared with those randomized to coronary artery bypass graft (CABG [6%]), to attain angina-free status at 5 years. However, since the time of randomization of patients in the BARI (which occurred between 1988 and 1991), clinical practice has changed to reflect key new information acquired from more recent clinical trials. Among the most important of these changes is the use of coronary stents, which has revolutionized interventional cardiology. In 1994, 2 randomized trials<sup>2,3</sup>revealed that using stents reduced the restenosis rate by 30% compared with PTC A. Since these trials, we also have learned more about the appropriate indications for stent placement, including their use for abrupt vessel closure following PTCA<sup>4</sup>to reduce the need for emergency
ARTERIOVENOUS FISTULA
Authors: Kenneth E. Gamm
Journal: JAMA (1942)

A careful search of the literature since Steinmann first described the use of his pin for skeletal traction in 1907 has failed to produce a report of an arteriovenous aneurysm resulting from its use. It seems amazing that some instances have not been reported when one considers the proximity of the anterior tibial artery and vein to the anterior tibial crest at its distal third. The use of the Steinmann pin for skeletal traction gained popularity in this country in 1918 following the war, and further impetus to this means of traction was added by the publishing of Böhler's fracture book in English in 1929. In the eastern part of the country traction for tibial fractures is usually obtained by a pin through the os calcis, while in our section of the country it seems to be the rule to place it through the distal end of the tibia and
Intramuscular Heparin
Authors: D. G. Abrahams
Journal: BMJ (1950)

BiuTRsHIn eight cases of-arteriosclerosis in which the primary complaint was intermittent claudication, padutin, administered both by mouth and by intramuscular injection over periods of 14-21 weeks, had no effect on the claudication index or the postexercise blood flow through the calf.Eight cases of arteriosclerosis with claudication examined before and at varying times after sympathetic neurectomy showed no evidence of improvement in the claudication index or the post-exercise blood flow through the calf.I would like to thank Mr. E. J. Finnan, M.Sc., of the
Health professionals persecuted in violation of their human rights: a partial list of cases
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Systemic aspergillosis caused by Aspergillus niger after open-heart surgery
Authors: T. A. Malivi
Journal: JAMA (1968)

Systemic aspergillosis caused by<i>Aspergillus niger</i>occurred in a 9-year-old boy after he had undergone open-heart surgery. There were several possible alternate routes of inoculation. The clinical manifestations of the disease appear to be similar to those of most mycotic infections caused by opportunistic fungi.