tbuckley/cabot-search huggingface dataset:
1998 NEUROTUMOR CLUB March 30, 1998, New Orleans, La.
Authors: C. L. Gladson
Journal: Neuro-Oncology (1999)

Tumor cell invasion requires tumor cell attachment to the extracellular matrix, secretion of proteases that digest the extracellular matrix, and tumor cell motility.These events are amplified or modified by a complex series of signaling events.Some of these signaling events are initiated by growth factor or extracellular matrix protein interaction with tumor cell surface receptors (e.g., growth factor receptors and integrin receptors), whereas others are initiated inside the cell by the altered mechanism of action of tumor suppressor genes and signaling molecules.In the summary of 10 presentations below, there are examples of the expression of up-regulated or mutated molecules that trigger signaling events in malignant gliomas, Schwannomas, and meningiomas.These signaling events typically result in tumor cell proliferation or motility.Expression of several normal and constitutively activated mutant growth factor receptors are growth promoting in malignant astrocytomas.The work of Matt Feldkamp and A.
Mesomorph Metamorphosed
Authors: Lawrence D. Grouse
Journal: JAMA (1982)

Youth has always been wasted on the young, but I was disturbed to discover that middle age is also being wasted on the middle-aged. I had always imagined that the middle-aged person should be as Shakespeare described: In fair round belly with good capon lined, With eyes severe and beard of formal cut, Full of wise saws and modern instances; Women, of course, could omit the beard. But as a middle-aged mesomorph myself, I have been amazed to find that contemporary images of prosperous middle age do not involve portly mesomorphs in their prime, busy with the affairs of the world. No longer is the mesomorph regarded as the natural product of middle age and a pinnacle of evolution. Our potbellies and the proliferation of our chins have become an embarrassment rather than an achievement. <h3>Uncle Pierre's Gourmet Diet</h3> To shed my mesomorphic shell and inherit the privileges of contemporary
Incorrect <i>P</i> Value in Table 3
Journal: JAMA Dermatology (2017)

Aravind Krishnan, BA; Tim Xu, MPP; Susan Hutfless, PhD; Angela Park; Thomas Stasko, MD; Allison T. Vidimos, MD, RPh; Barry Leshin, MD; Brett M. Coldiron, MD; Richard G. Bennett, MD; Victor J. Marks, MD; Rebecca Brandt; Martin A. Makary, MD, MPH; John G. Albertini, MD; and the American College of Mohs Surgery Improving Wisely Study Group
Three Views on Birth Control —Ethical, Mathematical, Medical
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Headache
Authors: Charles M. Poser
Journal: JAMA (1980)

The task for the practicing physician of deciding which books to add to his already crowded shelf is becoming more and more difficult as an avalanche of publications continues to descend on him. It is therefore an unusual and delightful event when a book comes along that not only fulfills a very real need and appeals to a large audience but also attains a level of perfection in all respects. Raskin and Appenzeller, both well known for their long-standing and extremely productive writings on headache and other pains, have joined in assembling a monograph that is comprehensive, lucidly written, and filled with both critical and commonsense observations. It is obvious that both authors are experienced clinicians who have spent many hours listening with understanding and sympathy to the endless litanies of headache sufferers. In fact, I would strongly suspect that the authors themselves are migraineurs. To say that they have
"Pilot" Studies
Authors: John E. Nelson
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 July 1989"Pilot" StudiesJohn E. Nelson, MD, PhDJohn E. Nelson, MD, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-2-188_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The study of megestrol acetate in the treatment of cachexia associated with human immunodeficiency virus (HIV) infection by Von Roenn and colleagues (1) and their reasons for doing a nonrandomized, nonblinded, and uncontrolled study deserve further comment (2).Dr. Von Roenn puts the cart before the horse in stating (3) that "a potential benefit, without undue toxicity, must be shown before a placebo-controlled study is appropriate." The reason for doing a blinded and controlled trial is to determine if the proposed treatment is "beneficial and without undue toxicity." A reasonable hypothesis, and not previous proof of benefit,...References1. Von RoennMurphyWeber JRK. Megestrol acetate for treatment of cachexia associated with human immunodeficiency virus (HIV) infection. Ann Intern Med. 1988;109:840-1. LinkGoogle Scholar2. Furth P. Megestrol acetate and cachexia associated with human immunodeficiency virus (HIV) infection [Letter]. Ann Intern Med. 1989;110:667. LinkGoogle Scholar3. Von RoennMurphyWeber JRK. Megestrol acetate and cachexia associated with human immunodeficiency virus (HIV) infection [Letter]. Ann Intern Med. 1989;110:667-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1989Volume 111, Issue 2Page: 188-189KeywordsCombined antiretroviral therapyHIVHIV infectionsPilot studiesToxicity ePublished: 1 December 2008 Issue Published: 15 July 1989 PDF downloadLoading ...
Immigrant attitudes toward the physician
Authors: R. Anderson
Journal: JAMA (1990)

<h3>In Reply.—</h3> I am most grateful to Dr Anderson for his letter. It is gratifying to learn that his clinical research as a physician-anthropologist interested in ethnomedicine confirms many of the conclusions I have drawn based on historical data and some contemporary reports. His interest in my essay suggests how much there is to be gained when doctors of medicine and doctors of history share their insights and expertise. I do not wish to dwell on the sentence that Dr Anderson quoted out of context in the last paragraph of his letter. As an American historian working primarily in immigration and ethnic studies, I would be the last to suggest that American standards of health and hygiene are uniformly superior to those of other countries. In this case, I believe the pejorative connotation was supplied by the reader, not the author. Those who peruse the entire article should have
Increased intrahepatic Th1 cytokine mRNA levels correlate with tissue damage in chronic hepatitis C 1. 1AW Morrow Gastroenterology and Liver Center and 2 Department of Pathology, Royal Prince Alfred Hospital, Sydney Australia
Journal: Hepatology (1995)

Sequences of the HIV-2 envelope C2–C3 region were obtained after direct PCR amplification of proviral DNA from the brain and peripheral blood mononuclear cells of an HIV-2-infected AIDS patient. Tissue-specific sequences confirmed previous observations that HIV-2 is indeed present in the central nervous system of infected individuals. Distinct but related quasi-species were present in these two different tissues of the same individual. Residues at position 18 and 19 of the V3 loop and overall charge of the loop suggest that the brain virus was NSI/macrophage tropic; whereas the sequences from the two blood samples were indicative of a SI/T-cell tropic virus. This is the first description of these two genotypes in the same HIV-2-infected individual. Analysis of more samples from different compartments would help to better understand tissue-specific factors in quasi-species evolutionin vivo.
FUNCTIONAL TESTS FOR GASTRIC SECRETION
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Tables.
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Études neurologiques.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Graduate Education in Public Health
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heart Attack
Authors: Walter McDonald
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Decreased constitutive murine cytochromes P450 by staphloccocal enterotoxin B (SEB) . Dept. Veterans Affairs Medical Center/University of Kentucky, Lexington, KY and *National Institute Occupational Safety Health, Cincinnati, OH
Journal: Hepatology (1995)

The activation of host defense mechanisms has been shown to cause a depression in hepatic cytochrome P450-mediated metabolism in rodents and humans. In a previous study, it was demonstrated that the Gram-positive bacteria Listeria monocytogenes causes a down-regulation of hepatic cytochrome P450 and related substrate metabolism as a result of a pretranslational depression of apoprotein synthesis. The objectives of this study were to determine whether the effect of listeria on hepatocyte cytochrome P450 involves hepatic nonparenchymal cells and whether the hemolysin, secreted only by hemolytic forms of the bacteria, plays any part in mediating this effect. Total cytochrome P450 levels as well as ethoxyresorufin-O-dealkylase (EROD) and benzyloxyresorufin-O-dealkylase (BROD) activities were significantly reduced in hepatic microsomes isolated from mice infected in vivo for 48 h with 15U listeria, whereas the same dose of the avirulent non-hemolytic M3D strain had no effect. Listeria (15U) significantly depressed hepatocyte EROD and BROD activities after 24 h incubations with liver cell cultures containing hepatocytes and nonparenchymal cells, as the result of both a direct effect on the hepatocyte and an interaction of listeria with hepatic nonparenchymal cells. The M3D strain of listeria had no effect on cytochrome P-450-mediated metabolism in isolated cells, confirming that hemolysin is an essential component of the mechanism responsible for the down-regulation of cytochrome P450 during listeria infections.
Needle aspiration biopsy: a critical appraisal. Eight years and 3,267 specimens later
Authors: T. S. Kline
Journal: JAMA (1978)

Fine-needle aspiration biopsy was used to diagnose lesions from the breast, subcutaneous nodules and lymph nodes, prostate, deep masses, lung, and pancreas. Over an eight-year period, 3,267 specimens were examined. The biopsy specimens were taken with 18- to 22-gauge disposable needles with attached syringes, were fixed immediately, and were stained according to the method of Papanicolaou. Frequently, the aspiration was done as an office procedure. The method was essentially complicationfree. The biopsy specimen was easy to interpret, and the procedure had an overall accuracy of approximately 90%. It should be used by all clinicians, especially on the initial visit of the patient. (<i>JAMA</i>239:36-39, 1978)
Injection mammography
Authors: R. W. Wayne
Journal: JAMA (1977)

WITH THE advent of mammography and xeromammography, the occult nonpalpable lesion has created a new problem for both the surgeon and pathologist. A small lesion is usually difficult and sometimes impossible for the surgeon to locate at the time of biopsy and, therefore, frequently necessitates a large deforming biopsy to ensure removal of the lesion. If the lesion is benign, the patient is left with a permanent breast deformity. Several techniques have been advocated to assist in localizing the nonpalpable lesions.<sup>1-4</sup>The injection of a mixture of Evans blue dye or indocyanine green and radiopaque contrast material has proved to be a successful method in our series. A protocol (Fig 1) is recommended in the radiographic assessment of nonpalpable lesions of the breast. <h3>Method</h3> Several hours prior to surgery, two parts of a mixture of meglumine and sodium salts of diatrizoate (Renografin 60) was combined with one part of
Books Received
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
使用普萘洛尔治疗IH的BSPD指南
Authors: L. Solman, M. Glover, P.E. Beattie, H. Buckley, S. Clark, J.E. Gach, A. Giardini, I. Helbling, R.J. Hewitt, B. Laguda, S.M. Langan, A.E. Martinez, R. Murphy, L. Proudfoot, J. Ravenscroft, H. Shahidullah, L. Shaw, S.B. Syed, L. Wells, C. Flohr
Journal: British Journal of Dermatology (2018)

婴幼儿血管瘤(IH)是婴儿常见的胎记,由扩张的血管组成。这些胎记也称为草莓痣。大多数草莓痣会生长几个月,然后在几个月或几年间自发地逐渐缩小。但是,在大约15%的病例中,它们会累及眼、耳、口、鼻和肛周等部位,造成严重的功能障碍。此外,它们有时能够消退,但造成毁容。2008年,有报告称,β‐受体阻滞药普萘洛尔经口服用(口服),能够非常有效地使这些胎记迅速缩小。本文旨在就如何最好地对IH儿童患者使用普萘洛尔为医生提供指南。制定指导涉及多个阶段:对八个欧洲国家/地区的现行实践开展国际性调查;系统性文献综述;从19个中心收集当地现行指南生成70项声明。然后由来自相关专科(皮肤科、儿科、儿科心脏病学和儿科ENT外科)的19名专家仔细审查这70项声明。使用既定的研究方案,经由这些专家就涵盖八个类别的47项声明达成一致。这些类别包括:开始服用普萘洛尔的适应症(即应在哪些情况下服用);禁忌症(即不应在哪些情况下服用);所需的治疗前测试;开始治疗;治疗期间的监控以及何时停止治疗。这些声明还涵盖了出现其他并发症的儿童的治疗。虽然这些指南在英国实施,但是作者希望对欧洲的其他国家/地区同样有用。
Skiing Lacerations
Authors: Thomas G. Colmey
Journal: JAMA (1980)

Analysis of all ski injuries recorded at Vail, Colo, during the 1973-1974 season showed that 178 injuries occurred in which the skier was lacerated by his own ski. This represented approximately one out of every ten ski injuries—a ratio that remained constant during the six seasons from 1972 through 1978. Frequently these lacerations occurred about the head and face and were cosmetically serious in nature. It is believed that such injuries are largely preventable. The use of ski brakes as an alternative to runaway straps could appreciably lower the incidence of these injuries. (<i>JAMA</i>244:1699-1700, 1980)
Infections of the Hand.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biology and Genetics of Hereditary Motor and Sensory Neuropathies
Authors: U Suter
Journal: Annual Review of Neuroscience (1995)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More