tbuckley/cabot-search huggingface dataset:
THE NEW INDEX MEDICUS.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preventive strategies in sexually transmitted diseases
Authors: Robin O. Motz
Journal: JAMA (1988)

<h3>To the Editor.</h3> —A recent article by Graboys et al<sup>1</sup>discussed reducing the incidence of coronary artery surgery by obtaining a second surgical opinion. It therefore appears that some patients recommended to have coronary artery surgery by the first physician actually did well without surgery. However, the reciprocal question has never been examined properly; that is, in how many cases when the first physician does not recommend surgery for angina would surgery actually benefit the patient? I think that a protocol should be established to answer this question. Each patient who has new angina or a change in his anginal pattern could be entered in the study. Of those in whom surgery is not recommended, half of them would then be referred to a second physician for a second opinion to see whether surgery was then recommended. The mortality and morbidity of the placebo and second-opinion groups could then
Management
Authors: Gary Meller
Journal: JAMA (1987)

The cost of health care in the United States continues to grow despite numerous strategies to limit increases in expenditures. The total annual cost to society now approaches $500 billion. At times, it appears that the complexity of practicing medicine has increased even faster than either our knowledge of disease or our ability to treat. Patients and professionals are confronted with a bewildering array of financial arrangements, payer mechanisms, and business concerns.<sup>1-3</sup>Increasingly, physicians are becoming directly involved in the management of the health care system. Group practices have increased from 6371 in 1969 to more than 16 000 in 1986.<sup>4-6</sup>Physicians who lead groups must assemble a team of experts to manage and evaluate not only the medical performance of their colleagues, but also their economic performance. Managing a group practice requires knowledge of marketing, finance, personnel management, billing and reimbursement, contracts with payer organizations, benefit and
Primary prevention of sexually transmitted diseases. A primer for clinicians
Authors: K. M. Stone
Journal: JAMA (1986)

With the advent of sexually transmitted infections for which curative therapy is not available, primary prevention has assumed greater importance. The spectrum of sexually transmitted diseases (STDs) has broadened, and clinicians need to understand the mechanisms of their transmission and prevention. Modifying selection of sexual partners and avoiding certain sexual practices should theoretically reduce the risk of infection. Clinical and laboratory studies indicate that the use of condoms, diaphragms, and spermicides reduces the risk of acquiring certain infections. At present, hepatitis B is the only STD for which a safe, effective vaccine is available. Use of oral antibiotics cannot be recommended. Postcoital washing or urination have not been shown to have a protective effect against infection. Because of the potential benefits, persons at risk for STDs should be encouraged to modify their sexual behavior and use barrier methods and spermicides to protect themselves against sexually transmitted infections. (<i>JAMA</i>1986;255:1763-1766)
Abstract 3760: Identifying site-specific disparities in the tumor microenvironment of primary and metastatic disease
Authors: Krysten E. Vance, Micheal A. Hollingsworth, Paul Grandgenett
Journal: Cancer Research (2019)

Abstract The tumor microenvironment (TME), or all cellular and molecular components in and around the tumor, has a well-documented impact on cancer cell proliferation, chemoresistance, and overall patient survival. However much of the research into the TME has been limited to the primary site. How the TME of metastases compares to the primary lesions remains poorly characterized, even though metastasis is responsible for 90% of all cancer deaths. Understanding these differences is critical to treating advanced cancer patients. To study this our lab examined the TME in 22 matched sets primary pancreatic tumors and liver metastasis obtained from end-stage pancreatic cancer patients via our rapid autopsy program. We used a multiplex-immunofluorescent technique that allows staining of a single slide with up to 35 antigens and characterized the presence, position and functional statues of cells that comprise the pancreatic TME. These included: tumor cells, vasculature, fibroblasts, macrophages, mast cells, basophils, eosinophils, B cells, T cells, and NK cells, along with multiple subtypes of these. Based on our preliminary data from this, we hypothesize that the organ determines the features of the TME. Analyzing primary tumors and metastases revealed that both the composition and spatial distribution of different cell types are distinct between the primary tumor and liver metastases. PAM clustering of the cellular featured grouped primary tumor with primary and metastasis with metastatis 87% of the time. As the TME has been shown to impact chemotherapeutic response, we further examined chemotherapeutic effect between sites. Comparing gemcitabine (standard of care) and untreated patients, we observed distinct site-based responses. In the primary tumors with gemcitabine treatment there was a significant increase in inflammatory cells (neutrophils and macrophages) in comparison to untreated patients, while in the liver gemcitabine induced an increase in desmoplasia (SMA). Combined this data indicates that the distinct TME’s exist within the same patient in an organ specific manner which can impact chemotherapeutic response. Understand these differences is therapeutically critical to patients whose therapeutic strategies involve targeting the TME to improve drug delivery, modulate immune suppression or otherwise modulate the microenvironment. Citation Format: Krysten E. Vance, Micheal A. Hollingsworth, Paul Grandgenett. Identifying site-specific disparities in the tumor microenvironment of primary and metastatic disease [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3760.
Lung Function and Death from Chronic Obstructive Pulmonary Disease in α1-Antitrypsin MZ Heterozygotes
Journal: Annals of Internal Medicine (2002)

Summaries for Patients19 February 2002Lung Function and Death from Chronic Obstructive Pulmonary Disease in α1-Antitrypsin MZ HeterozygotesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-4-200202190-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Chronic obstructive pulmonary disease (COPD) is a type of lung disease that is usually caused by cigarette smoking. The lungs of people with this disease are progressively destroyed by the irritation caused by cigarette smoke and by infection (bronchitis) that often accompanies smoking. Normal people can usually limit the destructive effects of this irritation because the body manufactures a protein that calms the inflammation caused by irritation from cigarette smoke. This protein (α1-antitrypsin) is produced because of the genes that we inherit from our parents. Each parent contributes ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Change in Lung Function and Morbidity from Chronic Obstructive Pulmonary Disease in α1-Antitrypsin MZ Heterozygotes: A Longitudinal Study of the General Population.” It is in the 19 February 2002 issue of Annals of Internal Medicine (volume 136, pages 270-279). The authors are M Dahl, A Tybjærg-Hansen, P Lange, J Vestbo, BG Nordestgaard.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChange in Lung Function and Morbidity from Chronic Obstructive Pulmonary Disease in α1-Antitrypsin MZ Heterozygotes: A Longitudinal Study of the General Population Morten Dahl , Anne Tybjærg-Hansen , Peter Lange , Jørgen Vestbo , and Børge G. Nordestgaard Metrics 19 February 2002Volume 136, Issue 4Page: I-35KeywordsBreathingChronic obstructive pulmonary diseaseGenetic diseasesHematologic testsHospitalizationsLongitudinal studiesLungsProteinsQuestionnairesSmoking habits ePublished: 19 February 2002 Issue Published: 19 February 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
BAP1 loss in hepatocellular carcinoma is associated to PKA activation and fibrolamellar features
Authors: Theo Hirsch, Ana Negulescu, Barkha Gupta, Stefano Caruso, Bénédicte Noblet, Gabrielle Couchy, Quentin Bayard, Lea Meunier, Guillaume Morcrette, Jean Yves Scoazec, Jean-Frédéric Blanc, Giuliana Amaddeo, Jean-Charles Nault, Paulette Bioulac-Sage, Marianne Ziol, Aurélie Beaufrère, Valérie Paradis, Julien Calderaro, Sandrine Imbeaud, Jessica Zucman-Rossi
Journal: Journal of Hepatology (2020)
:Influence of the high-affinity growth hormone(GH)-binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH Modeling analysis and clinical applications
Journal: Journal of Clinical Investigation (1993)

Because of author's errors, the following changes were made to the article.Please note that this correction supersedes that in the May 1993 issue and incorporates those changes made because of publisher's errors.Page 629, left hand column, lines 15 and 16 in the Abstract, should read: ". . .momentary levels of free, bound, and total GH, the percentage of GH bound to protein, and the percentage occupancy. .Page 630, left hand column, line 4, should read: ". . .equilibrium Kd of 1.5 nM as a nominal value.Page 630, left hand column, line 10, should read: ". . .has a mass either 2.2 or 22,g (0.1 or 1.0 nmol .Page 630, left hand column, footnote 3, lines 4 and 5, should read: "We have used the nominal value of 1.5 nM for most of the present work."Page 630, right hand column, lines 5 and 6, should read: ". . .for GH elimination (which is related to its t12 by In 2/ks, min).Page 630, right hand column, line 32, should read: ". . .and our measured koff of 0.037 min .."Page 631, Table I: the column heading that now reads "GH bound to protein" should read "GH bound to BP." Page 631, left hand column, line 29, should read: ". . .mg/24 h (5, 15, and 50 nmol/24 h) . .."Page 631, right hand column, line 5, should read: ". . .conditions that are more akin to those. .Page 632, Figure 2 legend, line 8, should read: ". . .was assumed to be formed (kol = 2.47 x 107 M'/min). .
Natural history of hepatobiliary-hypointense only nodules found at magnetic resonance imaging with Gd-EOB-DTPA: time-dependent effects of dimensional increase and diffusion weighted imaging alterations
Authors: Luca Ielasi, Matteo Renzulli, Francesco Tovoli, Irene Pettinari, Francesca Benevento, Alessandro Granito
Journal: Journal of Hepatology (2020)
Organization Section
Authors: Mary Arnold, New York, Linda Banning-Krikawa, Joyce Barnett, Stephen Bartlett, Brooke Bensen, Brian Berelowitz, Deborah Biscoe, James Austin, Patricia Blaine, Elaine Blubaugh, J Boswell, C Gregory Boyer, Virginia Branson, Ben Beach, Michael Bridges, Agnes Brown, David Buckley, Lori Buller, Thomas Cahill, Margaret Cahill, San Carter, Patrick Antonio, Steven Catalano, Francesco Chase, Joan Chiarelli, Robin Colgin, David Crawford, E Cutler, Julie Enenbach, Leonard Fagen, Lisa Fontaine, Ct Gaber, Julie Galley, Patti Geil, Richard Gerwin, Andrea Giaccari, San Antonio, Gina Gilbert, Whitmore Lake, Helen Gipson, Ira Gottlieb, Severna Park, Marcia Graber, Martin Halpern, Susan Haynes, Sally Hill, Dorisann Horridge, Annegret Howe, Leah Hunter, John James, Diane Kachajian, Robert Kavieff, Gary Kiley, Alan Kiselstein, Rancho Mirage, Steven Koevary, James Lawton, William Leet, Michele Leonardi, Ft Washington, Mary Lewis, Lorraine Loretz, Nance Lovelace, Nj Lowe, Thomas Lowe, David Madoff, Owings Mills, Paul Mamula, San Francisco, Mary Marzano, Patricia Mcswain, Elvira Melian Perez, Thomas Merritt, Janice Munjas, Sherman Nagler, Lucille Nepon, Darby O'donnell, Maria Olvera, San Ysidro, Ruth Oman, Little Rock, Ann Peterson, John Phelan, Arlyn Pittler, St Louis
Journal: Diabetes Care (1989)
Error in Figure
Journal: JAMA Cardiology (2017)

Gregg C. Fonarow, MD; Anthony C. Keech, MD; Terje R. Pedersen, MD; Robert P. Giugliano, MD, SM; Peter S. Sever, PhD, FRCP; Peter Lindgren, PhD; Ben van Hout, PhD; Guillermo Villa, PhD; Yi Qian, PhD; Ransi Somaratne, MD; Marc S. Sabatine, MD, MPH
The virus of poliomyelitis. From discovery to extinction
Authors: J. Salk
Journal: JAMA (1983)

Gustavson<sup>1</sup>defined science as that body of knowledge obtained by techniques that enable us to place limiting values on our preconceptions. A review of what we now know about poliomyelitis reveals a list of preconceptions that have been modified with the help of techniques developed to examine them. When ideas are transformed in this way, it is oftentimes difficult to understand why we thought as we did previously. It was once believed that (1) poliomyelitis was not an infectious disease, (2) the virus reached the CNS via nerve pathways and not via the bloodstream, (3) the virus was strictly neurotropic, unlikely of cultivation in nonneural tissue, and (4) the prevention of the disease could not be accomplished by a noninfectious virus vaccine because it was also believed that (5) the process of infection was required for inducing effective and durable immunity. The scientific investigation of these and other questions
PUBLIC OPINION AND MEDICAL EDUCATION.
Journal: JAMA (1907)

The public holds the medical profession responsible for any abuses which occur in connection with medical institutions and in medical affairs. This is as it should be, since medical men alone are in position to recognize such abuses and to suggest the steps necessary for their correction. If the facts about any worthy reform are plainly stated and it is made clear that the reform asked for is for the benefit of the public and not merely for the selfish interests of the medical profession, the public, through the public press, can usually be counted on for strong support and it will join the profession in demanding that reform. That this is true the medical profession has been slow to recognize. The above statements are well supported in the extensive publicity given by the press to a statement issued by the Council on Medical Education some weeks ago regarding medical
Clinical Lectures on Dislocations, Delivered at the Charing - Cross Hospital
Authors: H. Hancock
Journal: BMJ (1845)

Among infants and gung children the epiphysis at the surgical neck of the humerus is sometimes dis- united; in infants, during parturition, in conequence of the inadvertence or want of skill of the midwife or medical attendant.M. Rognetta, in the Gazette Medicale for the year 1834, has published a series of very interesting papers on the separation of the epiphyses -in geneal, and I would recommend you to read them, as thdye ontain more information upon this subjeet than any pther work written.Disectioasnoemsof congenital lilxation have not been recorded mi sufficient numbers to afford any certain data upQn' which *e can come to any satisfac- tory conclusion upon the subject; but it appears to me notat all improbable that some of the cases recorded as csgenital dislocations, may, in reality, have been displacemehts of o gpiphyses from violence inflicted at-the hour of birth.At all events, the cases which I will here relate to you, and for which I am indebted to M. Rognetta's paper, would certainly lay the founda- tien fbr such an opinion.CASE I.Bertrandi, in his " Opere Anatomicbe e Cirusiche," vol. 5, p. 164, oierves, I have had occasion to open the body of an infant, still-born; the caw had been ape of arm presentation, and the midwife had pulled ii n it in her endeavours to deliver the child.The head of the bonewas detached from the shaft.CASE II.M. Dubroca, in the Bulktin Medical de Bordeaur, relates the cas of, a child in whom the head of the humerus was separated at the4iphysis, tbrough the malpractice of the midwife, who, ater the child's head was born, endeavoured to disengae the shoulders by pressing upon them with her thumb.M. Dubroca treg,d the case, and the infant was cured in eight dayx, but the bandage was-not removed for fifteen, -at which tithe the callus was so abundant that the humerus was three timninazatural sizeat the seat of separRtion, but it gradually disappeared.CASES III.AND I-Y.M. Delamotte, in the third edition of his " Surgical Observations," p. 350, gives the account of two women whom he attended about the same time.In both cases LNo. 1, japuq 1, I 4
Air drop bundles average 9:1 food to medicine
Authors: P. Gunby
Journal: JAMA (1993)

AIR DROPS over what was Yugoslavia this winter and spring are averaging one medical bundle for every nine food bundles. Provided by the US Army in Europe, the medical bundles include "sick call kits" with 31 items from aspirin and antibiotics to dressings, bandages, and blankets, to military trauma field kits with 58 items ranging from dressings and bandages to tracheostomy kits and splints. There also are medical items donated by other nations. The Office of the Command Surgeon (Charles H. Roadman II, MD, a brigadier general [<i>JAMA</i>. 1992;268:1389], is command surgeon), Air Mobility Command, Scott Air Force Base, Ill, in consultation with (US) European command officials, notes that the air drops are being made from 3000 m (10000 ft) or higher at night to avoid small-arms fire and shoulder-launched missiles from the ground. Eighteen C-130 "Hercules" turboprop cargo planes make the 5-hour flight from Rhein-Main Air Base at Frankfurt-am-Main,
CONTAGIOUS CHARACTER AND TRANSFERABILITY OF CANCER BY INOCULATION
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Donald Leung, Stanley Szefler, Colo Associate, Cezmi Akdis, Davos Switzerland, Andrea Apter, Pedro Philadelphia, Chicago Avila, Bruce Bochner, Joshua Boyce, Robert Bush, Fred Finkelman, Cincinnati Ohio, Dennis Ledford, Tampa Fla, Deborah Meyers, David Peden, Marc Rothenberg, William Shearer, Scott Sicherer, New York, Donata Vercelli, Erika Von Mutius, Statistics Editor, Vernon Chinchilli
Journal: Journal of Allergy and Clinical Immunology (2011)
Effect of propylthiouracil on the ethanol-induced increase in liver oxygen consumption in awake rats
Authors: F Carmichael
Journal: Hepatology (1993)

It has been postulated that the beneficial effects of the antithyroid drug propylthiouracil in the treatment of alcoholic liver disease depend primarily on the action of propylthiouracil in suppressing the increase in hepatic oxygen consumption induced by ethanol. The evidence for this effect of propylthiouracil is derived from studies in which liver oxygen consumption has been determined in in vitro preparations. In our study the effects of ethanol and propylthiouracil on liver oxygen consumption were assessed in vivo in an unrestrained and unanesthetized rat model, where liver blood flow and hepatic vein and portal vein oxygen content can be measured. Data show that the liver oxygen consumption increased in rats treated with ethanol-containing liquid diets for 4 to 6 wk, both on withdrawal of alcohol (30%, p < 0.01), and after readministration of ethanol (50%, p < 0.01). Single-dose ethanol administration increased portal tributary blood flow without affecting hepatic arterial blood flow in both controls and rats withdrawn from long-term ethanol treatment. Long-term ethanol administration per se had no effect on portal tributary blood flow; however, hepatic arterial blood flow was increased by 38% (p < 0.01). Treatment with propylthiouracil for 5 days resulted in complete suppression of the increase in liver oxygen consumption induced by long-term ethanol administration. Propyithiouracil treatment also attenuated the increase in portal tributary blood flow after the administration of a single dose of ethanol. These determinations were made 24 hr after the last dose of propylthiouracil. In conclusion, use of a new in vivo model with unrestrained and unanesthetized rats has confirmed that long-term administration of ethanol increases liver oxygen consumption. For the first time, it has been shown in vivo that propylthiouracil abolishes the ethanol-induced increase in liver oxygen consumption that follows long-term ethanol administration. (HEPATOLOGY 1993;18:415–421).