tbuckley/cabot-search huggingface dataset:
Error in Figure Legend
Authors: Alexander Flint
Journal: JAMA Neurology (2015)

ing a statin as an outpatient.We find a similar strong relationship between inpatient statin use and outcomes when we perform this type of analysis.Among patients not taking a statin as an outpatient prior to hospitalization, the odds ratio for inpatient statin use in multivariable logistic regression predicting being alive at day 30 is 2.81 (95% CI, 2.12-3.73;P < .001)and the odds ratio for inpatient statin use predicting discharge to home or inpatient rehabilitation facility is 2.02 (95% CI, 1.6-2.54;P < .001).It should also be noted that in the original article, we also showed the converse of this analysis: among outpatient statin users, statin cessation in the inpatient setting is strongly associated with worsened outcomes (Figures 1 and3).
Dieffenbachia Toxicity
Authors: W. G. Walter
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Several articles and communications have appeared inThe Journalconcerning poisoning by plants of the genus<i>Dieffenbachia</i>and their probable toxic constituents. Drach and Maloney<sup>1</sup>and Dore<sup>2</sup>implied that toxicity was due to insoluble and/or soluble oxalates or glycosidal principles. Pohl<sup>3,4</sup>suggested a protein as surmised from work by Rizzinni.<sup>5</sup>From investigations in our laboratory, I would like to report for the first time the toxic principles of plants of this genus and the mechanism by which we believe they exert their activity. Toxicity is due to both an insoluble oxalate, calcium oxalate raphides (bundles of long slender needles), and to a proteolytic enzyme which we have designated "dumbain." In several species,<i>D exotic</i>and<i>D bausii</i>, an additional third toxic principle was found: a cyanogenetic glycoside which on hydrolysis yields hydrocyanic acid. <i>Dieffenbachia picta, D seguine</i>, and<i>D amoena</i>contain the free
American Journal of Clinical Pathology, Indianapolis
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BTC1.01 International survey regarding use of MGMT analyses for glioma
Authors: A Malmstrom, B Winther Kristenssen, R Henriksson, P Söderkvist
Journal: Neuro-Oncology (2018)

MGMT promotor methylation status is part of glioma diagnostics, supporting clinical decision making. Internationally different methods and cut-off levels are used to determine whether a tumor is methylated or unmethylated. Treatment decisions get unreliable, when methylation status of the tumor can change due to the analysis and cut-off used. We conducted an international survey, consisting of 27 questions, to clarify which methods are regularly used in different clinico-pathological settings and why a specific method is selected. We also asked about opinions regarding an international consensus on methods and cut-off levels. The survey was answered by 146 respondents - mainly neuropathologists - from 24 countries. The responses show that MGMT methylation status is determined for all gliomas in 37% of laboratories, while 8% do not perform the analysis. The most commonly used methods are msPCR (37%) and pyrosequencing (34%). The main reasons for choosing a specific method are simplicity (56%), cost-effectiveness (49%) and reproducibility of results (49%). For those using pyrosequencing, the most common number of CpG sites analyzed is four, but varies between 1–3 and more than 16. For 50% of laboratories, the company producing the kit determines which CpG sites should be examined, while 33% select the sites themselves. Selection of cut-off is equally distributed between a cut-off a) published in the literature, b) defined by the lab or c) defined by the company performing the analysis. This cut-off varies between different pathology departments. In one lab tumor is determined as methylated in case of 1 methylated CpG site of 17 analyzed. For others cut-off for methylated varies from 1% to 30%. Some report tumor as unmethylated or weakly versus highly methylated. An international consensus on MGMT methylation method is believed to be of advantage by 66%, while only 20% do not find this necessary. A consensus on a cut-off is warranted by 76%. Most suggest that the consensus method should be msPCR (45%) or pyrosequencing (42%), while 17% suggest next generation sequencing. While analysis and use of MGMT methylation status has become routine in the clinico-pathological setting, there is still controversy regarding the best laboratory method and the clinically relevant cut-off level. Most respondents suggest that an international consensus on both method and cut-off should be established.
Calcium Disorders
Authors: David J. Baylink
Journal: JAMA (1983)

The goal of this book is to acquaint physicians with the rapid advances in clinically relevant issues of calcium metabolism. Inasmuch as this is a book for the practicing physician, it is unclear why two chapters, on hereditary rickets and hypocalcemia of the neonatal period, are included in a book that is otherwise devoted to adult endocrinology. Also, it is unclear why Paget's disease, hypercalciuria, the diagnosis of osteoporosis, secondary osteoporosis, and renal stone disease were excluded. Certainly there have been rapid advances in those areas as well as the areas covered in this book. There are 11 British or Canadian authors and ten American authors. Not all of the information conveyed by non-US workers is relevant to the practice of endocrinology in the United States. For example, the chapter on acquired disorders of vitamin D metabolism, notwithstanding its special interest, deals extensively with a vitamin D deficiency in Asian
Variegate Porphyria
Authors: PERTTl MUSTAJOKI
Journal: Annals of Internal Medicine (1978)

In temperate and cold climates the most usual presenting symptom of variegate porphyria is an acute porphyric attack, indistinguishable from that seen in acute intermittent porphyria. Increased fragility of the skin in sun-exposed areas occurs in only half of such patients, and even then is usually mild and easily overlooked. The diagnosis depends on fecal excretion of porphyrins, which is greatly increased in variegate porphyria and consists predominantly of protoporphyrin. Urinary excretion of porphobilinogen and delta-aminolevulinic acid increases only during acute attacks. There are reasons for thinking that variegate porphyria is commoner than hitherto supposed. During an acute attack a patient without skin symptoms may well be misdiagnosed as having acute intermittent porphyria, because of identical symptoms and excretion of porphobilinogen in the urine. Thus, for a correct diagnosis, every patient presenting with symptoms of acute porphyria requires a fecal analysis.
Effects of Lead on Vascular Reactivity
Authors: Siangshu Chai, R. Clinton Webb
Journal: Environmental Health Perspectives (1988)

Considerable controversy exists concerning the possible role of lead in the etiology of human hypertension. In animal studies, there is convincing evidence that lead alters cardiovascular responsiveness; rats drinking water containing 100 ppm lead develop a chronic, significant 15 to 20 mm Hg elevation in systolic blood pressure. Pressor responsiveness to catecholamines is enhanced in animals chronically exposed to lead, and the responsiveness of isolated vascular smooth muscle to adrenergic agonists is increased in rats with lead-induced hypertension. Experimental evidence suggests that alterations in the cellular mechanisms that regulate intracellular calcium concentration may contribute to the abnormal vascular function in lead-induced hypertension. Recent work in our laboratory indicates that increased vascular reactivity in genetic hypertension is associated with altered activity of the protein kinase C branch of the calcium messenger system. Contractile responses to lead in rabbit mesenteric artery are potentiated by activators (phorbol esters) of this enzyme complex, and a selective inhibitor of protein kinase C inhibited contractions induced by lead. Based on these results, it is proposed that a cellular component of the action of lead to increase vascular reactivity may relate to the role of protein kinase C in smooth muscle contraction.
Complete traumatic rupture of the bronchus with minimal trauma
Authors: B. Winter
Journal: JAMA (1968)

A man with no history of trauma had localized wheeze and rhonchus in the left side of his chest. Clinical diagnosis of partial obstruction of the left main bronchus was confirmed by bronchoscopy and planography. Surgery revealed complete fracture of the left main stem with high-grade fibrous stricture between the fractured ends. Resection of the stenotic area with end-to-end anastamosis was performed. Questioning revealed trauma from a jeep accident 22 years earlier as the only source of the lesion.
Why now? Use of tetracycline in young children
Authors: A. S. Yeager
Journal: JAMA (1977)

Tetracyclines are not effective against viruses, which cause 90% of upper and 50% of lower respiratory tract infections in children, nor are they the drugs of choice for the four bacteria that cause pneumonia in children.<sup>1,2</sup>Provided there is no malnutrition or underlying disease, the usual causes of bacterial respiratory infections in young children are<i>Diplococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae</i>, or<i>Staphylococcus aureus</i>. While the toxicity of the tetracyclines in young children is not to be discounted, a more important argument against their use is that they are not the most effective drugs available against these bacteria. What remaining activity the tetracyclines have against the Enterobacteriaceae is of no benefit to the normal child afflicted with a respiratory infection. Organisms such as<i>Escherichia coli</i>are almost never the cause of the problem. Ray, Federspiel, and Schaffner report elsewhere in this issue (p 2069) that 80% of the children
Household Pesticides and Risk of Pediatric Brain Tumors
Authors: Janice M. Pogoda, Susan Preston-Martin
Journal: Environmental Health Perspectives (1997)

A follow-up to a population-based case-control study of pediatric brain tumors in Los Angeles County, California, involving mothers of 224 cases and 218 controls, investigated the risk of household pesticide use from pregnancy to diagnosis. Risk was significantly elevated for prenatal exposure to flea/tick pesticides -odds ratio (OR) = 1.7; 95% confidence interval (CI), 1.1-2.6-, particularly among subjects less than 5 years old at diagnosis (OR = 2.5; CI, 1. 2-5.5). Prenatal risk was highest for mothers who prepared, applied, or cleaned up flea/tick products themselves (OR = 2.2; CI, 1.1-4.2; for subjects <5 years of age, OR = 5.4; CI, 1.3-22.3). A significant trend of increased risk with increased exposure was observed for number of pets treated (p = 0.04). Multivariate analysis of types of flea/tick products indicated that sprays/foggers were the only products significantly related to risk (OR =10.8; CI, 1.3-89.1). Elevated risks were not observed for termite or lice treatments, pesticides for nuisance pests, or yard and garden insecticides, herbicides, fungicides, or snail killer. Certain precautions,if ignored, were associated with significant increased risk: evacuating the house after spraying or dusting for pests (OR = 1.6; CI, 1.0-2.6), delaying the harvest of food after pesticide treatment (OR = 3.6; CI, 1.0-13.7), and following instructions on pesticide labels (OR = 3. 7;CI, 1.5-9.6). These findings indicate that chemicals used in flea/tick products may increase risk of pediatric brain tumors and suggest that further research be done to pinpoint specific chemicals involved.
Evaluation of doxepin hydrochloride (Sinequan)
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pancreatic Surgery
Authors: Kenneth W. Warren, Richard B. Cattell
Journal: New England Journal of Medicine (1959)

THE pancreas — always an enigma to the physiologist, physician and surgeon alike — continues to guard with persistent jealousy its many mysteries. Despite the overwhelming volume of laboratory research and clinical observation directed toward achieving a better understanding of various phases of pancreatic disease, real progress in this area has been painfully slow. Although dramatic advances have not characterized the recent history of this study, the broad and insistent awareness of pancreatic problems that has been aroused within the medical profession during the past quarter century can be counted as a genuine achievement, and it may be anticipated, as . . .
March 15, 2000
Journal: JAMA (2000)

D. William Molloy, MRCP, FRCPC; Gordon H. Guyatt, FRCPC; Rosalie Russo; Ron Goeree, MA; Bernie J. O'Brien, PhD; Michel Bédard, MSc; Andy Willan, PhD; Jan Watson, RPN; Christine Patterson, MScN; Christine Harrison, PhD; Tim Standish, MA; David Strang, FRCPC; Peteris J. Darzins, FRACP, FRCPC; Stephanie Smith; Sacha Dubois, BA
Reducing Scutwork
Authors: George L. Ackerman, Louis L. Sanders
Journal: Annals of Internal Medicine (1991)

Letters1 December 1991Reducing ScutworkGeorge L. Ackerman, MD, Louis L. Sanders, MDGeorge L. Ackerman, MDSearch for more papers by this author, Louis L. Sanders, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-11-914_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In their recent article, Hayward and coworkers (1) define scutwork, list examples of scut cited by their residents, and note that the effect of such chores is to decrease job satisfaction among house officers. The study results suggest that both the faculty and residents feel that scutwork should be minimized, but the authors recognize that "it may prove difficult to identify persons who can do these tasks."We have been able to identify such persons and to minimize scut by appointing "health technicians" to each of the six ward teams at the McClellan Veterans Administration Hospital, a...Reference1. Hayward R, Rockwood K, Sheehan G, and Bass E. A phenomenology of scut. Ann Intern Med. 1991;115:372-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: George L. Ackerman, MD; Louis L. Sanders, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfur Amide Halogenides and DerivativesSulfur Amide Halogenides and Derivatives 1 December 1991Volume 115, Issue 11Page: 914-914KeywordsTechniciansVeteran care ePublished: 1 December 2008 Issue Published: 1 December 1991 PDF downloadLoading ...
OBSERVATIONS ON DÉBRIDEMENT OF WOUNDS
Journal: JAMA (1920)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SECTION OF DERMATOLOGY
Authors: A. C. Roxburgh
Journal: British Journal of Dermatology (1945)

Journal Article SECTION OF DERMATOLOGY Get access A. C. Roxburgh A. C. Roxburgh Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 57, Issue 3-4, 1 March 1945, Pages 68–74, https://doi.org/10.1111/j.1365-2133.1945.tb11202.x Published: 01 March 1945
Acne Vulgaris
Authors: Samuel M. Bluefarb
Journal: JAMA (1971)

This volume is an extensive, thoroughly referenced treatise on the clinical aspects, causative factors, and management of acne as viewed by an expert clinician. In a well-organized and readable form, the author has assembled most of what has been written or said about acne in the last 70 years. As such, Dr. Frank has provided a useful reference source for the serious student of this disease. After a short introductory section on clinical manifestations and variations, there are sections on histopathology, pathogenesis, and management, followed by a short discussion of acneform eruptions. However, as a practical guide for the average practitioner, the book presents a serious flaw. In an effort to be all inclusive, the sections on pathogenesis and treatment are cluttered with references to unsubstantiated, out-dated, and contradictory observations. As a result, no clear picture of the current thinking of pathogenic factors emerges. The discussion of therapeutic modalities omits
Quality of life.
Authors: N J Petrelli, L Herrera, A Mittelman
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.7.1041 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 4020400 Quality of life. N J PetrellixN J PetrelliSearch for articles by this author , L HerreraxL HerreraSearch for articles by this author , A MittelmanxA MittelmanSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.7.1041 PDF "Quality of life.." Journal of Clinical Oncology, 3(7), pp. 1041–1042© 1985 by American Society of Clinical Oncology
Otitis media and fever
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The recent article by Schwartz et al (1981;245:2057) provides strong evidence for the commonly held belief that high fever and acute otitis media are seldom associated. However, the article does not discuss why a few children do experience high fevers with otitis. I have been taught that the association of high fever and otitis occurs if one of three conditions is met: (1) there is an idiosyncratically exaggerated febrile response; (2) there is an intercurrent viral illness with viremia; or (3) there is a concurrent bacteremia. The work of the last decade<sup>1,2</sup>has shown that unsuspected bacteremia with high fever occurs commonly in young children at an age when they are also prone to otitis media and that the most common organisms in both conditions are<i>Haemophilus influenzae</i>and pneumococcus. Otitis has been shown definitely to occur in association with bacteremias with both organisms.<sup>1,3</sup>I
Remarks on Syphilisation
Authors: G. Gaskoin
Journal: BMJ (1866)

I found the left ventricle quite empty and firmly contracted, just as it has been found in cases of cho- lera.The right was occupied by a largish fibrinous clot extending up into the pulmonary artery.It did not appear of ante mortem origin.The lungs were congested.The absence of abdominal pain is not an argument against this view; as we know, from ob- servation of epilepsy, that an unfelt irritation may give rise to very severe symptoms.Cases of this nature would be more amenable to treatment than others; inasmuch as the intestinal irritation might be removed by appropriate remedies, as calomel and opium, castor-oil, etc.It is to be feared, however, that, in many cases, the heart, kidneys, and other organs, are too severely stricken in their vital powers to carry on their necessary functions, even when the irritation of the intestinal nervous structures is re- moved.In conclusion, I may say that I regard cholera as by no means a single and uniform morbid process, but -one which consists of several varying elements.These may be enumerated as cardiac paralysis, con- striction of arteries, alterations in the blood and ca- pillaries, intestinal irritation.They may be variously ,developed in different instances, some may be more marked in one case, others in another, and remedial means should be varied accordingly.