tbuckley/cabot-search huggingface dataset:
FEEING THE NURSE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A multifactorial model for pancreatic cancer in man. Epidemiologic evidence
Authors: R. S. Lin
Journal: JAMA (1981)

In the past 30 years, the incidence of pancreatic cancer has increased substantially. The disease now causes more deaths than all other malignant neoplasms, except those of the colorectal region, lung, and breast. A study in over 115 hospitals in five metropolitan areas showed that males with pancreatic cancer were more often employed in the dry cleaning business or in occupations involving close exposure to gasoline, increasing the risk for pancreatic cancer up to five times. Females at risk for pancreatic cancer were more likely to smoke cigarettes, to have uterine myomas, and to have undergone oophorectomy or spontaneous abortions. Generally, these patients were of higher social class and drank more wine and decaffeinated coffee than demographically similar controls. Assessment of the effects of several factors showed that relative risks increased 34-fold among females and nearly sixfold among males. While no single factor accounts for the preponderance of pancreatic cancer, a combination of factors—each associated with a relatively small risk enhancement—may very well do so. (<i>JAMA</i>1981;245:147-152)
Renal growth responses to acute and chronic injury
Authors: L G Fine, J T Norman
Journal: Journal of the American Society of Nephrology (1992)

Knowledge of the control of cell growth and extracellular matrix deposition has assumed center stage in the understanding of how the diseased kidney responds to injury. After acute tubular injury, there may be reversible, partial depolarization of renal cells or cell necrosis. The latter requires a regenerative response, which could be under the control of growth factors such as epidermal growth factor (EGF). Up-regulation of EGF receptors on viable cells provides the cell with an enhanced growth response despite a reduction in EGF production by the kidney. Acute glomerular injury involves a highly complex network of cytokines and growth inhibitors, the most important of which appear to be platelet-derived growth factor as a mitogen and transforming growth factor beta as an activator of extracellular matrix deposition. The long-term growth responses of the kidney to injury, reflected by chronic renal diseases, include tubular hypertrophy in those nephrons which are less affected by the primary disease. Tubular cell enlargement appears to proceed along a pathway that is different from the growth in cell size which precedes cell division, at least as indicated by a fundamentally different pattern of early gene expression. This pattern is not suggestive of a classical growth factor-initiated process. Other chronic changes that seem to correlate well with the progression of human disease are tubular atrophy and interstitial fibrosis. Growth factors produced by tubular cells may cause proliferation and matrix deposition by adjacent interstitial fibroblasts. A scheme is proposed in which low-grade ischemic injury to tubular cells, secondary to microvascular injury, leads to tubular atrophy, the release of growth factors, interstitial fibrosis, and the obliteration of peritubular capillaries. This would aggravate primary glomerular injury by compromising the vascular outflow from the glomerulus and would account for the long-recognized association between tubulo-interstitial injury and the progression of a variety of renal diseases. The use of growth factors to stimulate specific growth responses, antibodies, or inhibitory molecules to inhibit scarring generated by cytokines and the potential for genetic manipulation of the kidney provide future avenues for manipulating the growth response of the diseased kidney.
ORIGIN OF DERMOID CYSTS OF OVARY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Properties of the mouse α‐globin HS‐26: Relationship to HS‐40, the major enhancer of human α‐globin gene expression
Authors: Eric E. Bouhassira, Menno F. Kielman, John Gilman, Mary F. Fabry, Sandy Suzuka, Ofelia Leone, Ekatarinas Gikas, Luigi F. Bernini, Ronald L. Nagel
Journal: American Journal of Hematology (1997)

HS-26, the mouse homologue of HS-40, is the major regulatory element of the mouse α-globin gene locus. Like HS-40, HS-26 is located within an intron of a house-keeping gene; comparison of the nucleotide sequences of HS-26 and HS-40 reveals conservation of the sequences and positions of several DNA binding motifs in the 5′ regions of both elements (3 GATA, 2 NFE-2, and 1 CACCC sites) and the absence in HS-26 of three CACCC sites and one GATA site that are present in the 3′ region of HS-40, suggesting that the two elements might not be identical. We report here that when HS-26 is linked to a 1.5 kb Psti human α-globin gene fragment, it has a weak enhancer activity in induced MEL cells and in transgenic embryos, and it does not have any detectable activity in adult transgenic mice. This suggests that HS-26 does not have Locus Control Region (LCR) activity but can act as an enhancer during the embryonic life when integrated at a permissive locus. To further test the importance of HS-26 at its natural locus, we have generated embryonic stem cells and chimeric animals in which 350 bp containing HS-26 have been replaced by a neomycin resistance gene by homologous recombination. The sizes of the chimeras' red cells were then estimated by measuring forward scattering on a FacsScan apparatus in hypotonic conditions. This revealed that a fraction of the chimeric animals' red cells were smaller than normal mouse red cells and were very similar to cells from mice heterozygous for α-thalassemia. Density gradient analysis also suggested the presence of thalassemic cells. These results indicated that despite its lack of LCR activity, HS-26 is important for the regulation of the mouse α-globin gene locus. Am. J. Hematol. 54:30–39, 1997 © 1997 Wiley-Liss, Inc.
More on the GUSTO Trial
Authors: Paul M. Ridker
Journal: Annals of Internal Medicine (1994)

Letters15 November 1994More on the GUSTO TrialPaul M. Ridker, Christopher O'Donnell, Victor J. Marder, and Charles H. HennekensPaul M. RidkerSearch for more papers by this author, Christopher O'DonnellSearch for more papers by this author, Victor J. MarderSearch for more papers by this author, and Charles H. HennekensSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-10-199411150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We were surprised to read the letter by Lee and colleagues [1]. We had been requested by the Editors of Annals to respond to their commentary [2] and were provided with only two versions—an original dated 30 October 1993 and a revised draft dated 24 January 1994. Both drafts, provided by the GUSTO investigators to Annals, stated that the rates of coronary artery bypass surgery were 9.5% for accelerated tissue plasminogen activator (tPA) and 8.5% for streptokinase.References1. Lee KL, Califf RM, Topol EJ. The last word on GUSTO, for now (Letter). Ann Intern Med. 1994; 120:970. Google Scholar2. Lee KL, Califf RM, Simes J, Van de Werf F, Topol EJ, for the GUSTO Investigators. Holding GUSTO up to the light. Ann Intern Med. 1994; 120:876-81. Google Scholar Author, Article, and Disclosure InformationAuthors: Paul M. Ridker; Christopher O'Donnell; Victor J. Marder; Charles H. Hennekens PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAccelerated streptokinase in ST-elevation myocardial infarction — a romanian (ASK–ROMANIA) multicenter registryCurrent issues concerning thrombolytic therapy for acute myocardial infarction 15 November 1994Volume 121, Issue 10 Page: 818-820 Keywords Coronary arteries Surgery Tissue plasminogen activator ePublished: 15 August 2000 Issue Published: 15 November 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE EFFECTS OF FORMALDEHYD ON THE SKIN AND NAILS.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
La Traviata
Authors: C. James Favino
Journal: JAMA (1969)

<h3>To the Editor:—</h3> I greatly enjoyed your article, entitled "La Traviata" (208:93, 1969),, but I must call your attention to an error which might easily have been prevented. The sentence, "Verdi... made the leading lady 'a courtesan' named Violetta Valery, but elevated the poor struggling author to Baron Douphol," is incorrect. The "poor struggling author" became an untitled provincial youth named Alfredo Germont. Baron Douphol was the name given to Violetta's then current wealthy lover. I would agree that the physician in the audience should not concern himself with the quality of the medicine practiced in the last act, but will still have to read his own libretto.
Floating Kidney
Authors: ZVI H. OSTER
Journal: Clinical Nuclear Medicine (1988)

Tc-99m DTPA renal imaging was performed on a 62-year-old man because of suspected renal embolus. The patient was treated recently for endocarditis and had sudden, severe right flank pain that gradually subsided over the last 10 days. The images showed normal perfusion and function of the left kidney. Only what appeared to be the lower pole of the right kidney could be seen in the delayed images. A supine image showed the normally appearing collecting systems of both kidneys. The clue that alerted us to look for a “floating kidney” was the pattern of the collecting system, which seemed to be in the transverse position rather than in the normal vertical position. The appearance of the images was similar to that of another patient with a documented floating kidney. In both cases the kidney tilted forward and down with only part of the kidney facing the camera. This possibility should be considered in cases when part of the kidney is not visualized, and it is of extreme importance when calculating the relative function of the kidneys.
Atlas Fundus Oculi
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Informed Consent
Authors: George Crile
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I have read with interest Dr Laforet's scholarly communication on informed consent, and I agree that it is possible to carry its principle to absurd lengths. However, I do stand firmly behind the lines he quoted from my article on "Breast Cancer and Informed Consent." There is a vast difference between not informing a patient of all possible complications that could occur after a standard operation, eg, repair of a hernia, and not informing a patient about the various alternatives for treating a clinical stage I cancer of the breast. Since there is no agreement among authorities in the field of breast cancer, I think it is imperative that the patient be so informed. Only if she knows this can she participate in the making of the decision. The same principles apply to the treatment of small, low-lying rectal cancers. The patient should be informed that many
Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees
Authors: Mary E. Moore
Journal: Annals of Internal Medicine (2004)

Letters20 January 2004Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax KneesMary E. Moore, PhD, MDMary E. Moore, PhD, MDFrom Albert Einstein Medical Center, Philadelphia, PA 19141.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-2-200401200-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:To the casual reader, the paper by Sharma and colleagues (1) may convey the wrong message, that is, that quadriceps strengthening is harmful to some osteoarthritic knees. What the authors concluded was that, at 18-month follow-up, progression of tibiofemoral osteoarthritis in malaligned or lax knees was greater in those with high compared with low quadriceps strength at baseline. However, since the authors measured baseline quadriceps strength only and did not collect data during the 18-month interval, they cannot conclude that progression of tibiofemoral osteoarthritis was related to quadriceps strengthening. In fact, they apparently had no idea whether ...References1. Sharma L, Dunlop DD, Cahue S, Song J, Hayes KW. Quadriceps strength and osteoarthritis progression in malaligned and lax knees. Ann Intern Med. 2003;138:613-9. [PMID: 12693882] LinkGoogle Scholar2. Brandt KD. Is a strong quadriceps muscle bad for a patient with knee osteoarthritis? [Editorial]. Ann Intern Med. 2003;138:678-9. [PMID: 12693892] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Albert Einstein Medical Center, Philadelphia, PA 19141. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoQuadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees Leena Sharma , Dorothy D. Dunlop , September Cahue , Jing Song , and Karen W. Hayes Is a Strong Quadriceps Muscle Bad for a Patient with Knee Osteoarthritis? Kenneth D. Brandt Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees David Riley Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees Leena Sharma , Dorothy D. Dunlop , and Karen W. Hayes Is a Strong Quadriceps Muscle Bad for a Patient with Knee Osteoarthritis? Leena Sharma , Dorothy D. Dunlop , and Karen W. Hayes Quadriceps Strength and Osteoarthritis Progression in Malaligned and Lax Knees James Judge Metrics Cited ByAssessment of Hip and Knee Muscle Function in Orthopaedic Practice and Research 20 January 2004Volume 140, Issue 2Page: 149KeywordsExerciseExercise therapyKneesOsteoarthritisSulfatesTibiofemoral osteoarthritis ePublished: 20 January 2004 Issue Published: 20 January 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Vaccination of a patient receiving immunosuppressive therapy for lymphosarcoma
Authors: E. H. Rosenbaum
Journal: JAMA (1966)

Generalized vaccinia developed in a patient with lymphosarcoma and hypogammaglobulinemia who was receiving prednisone therapy. Experimental studies with guinea pigs receiving immunosuppressive drugs followed by vaccination were undertaken. Corticosteroids, alkylating agents, antimetabolites, and x-ray therapy may suppress the host's immunological response to infection. Experimental results showed that guinea pigs receiving mercaptopurine and methotrexate had marked vacciniallike lesions following vaccination. Smallpox vaccination may be contraindicated in patients who are receiving immunosuppressive agents, ie, mercaptopurine and methotrexate, for treatment of collagen, neoplastic, and autoimmune disease as well as for organ transplantations. Vaccination of such patients may be followed by vaccinia gangrenosa, generalized vaccinia, or death.
Refill: Yes or No?
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leads from the MMWR. Prevention of acquired immune deficiency syndrome (AIDS): Report of inter-agency recommendations
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Principles of Surgery
Authors: Berkeley Brandt
Journal: JAMA (1994)

<b>Principles of Surgery Companion Handbook</b>, edited by Seymour I. Schwartz, 6th ed, 771 pp, soft-cover, $27.50, ISBN 0-07056055-2, New York, NY, McGraw-Hill Publishing Co, 1994. This is the latest edition of what is now a standard surgical textbook. The editors claim that it is the most extensive revision to date. It is the 25th anniversary edition, and, in addition to new material, it has a number of new authors. The basic layout remains the same. Part 1, "Basic Considerations," has 12 chapters, six of which have new authors. It includes the usual subjects, such as "Fluids and Electrolytes and Nutrition," "Wound Care," "Complications," and "Infections." Other, more specific chapter subjects are "Trauma," "Oncology," and "Transplantation." All are well done and well illustrated. The chapter on infections has several very useful charts on antibiotics. Virtually all the chapters have new information, and part 1 is longer than that in the previous