tbuckley/cabot-search huggingface dataset:
Abstract 35: Integrin alpha-5 beta-1 and Fibronectin Receptor-Ligand Pair Determines Reparative and Neovascularization Potential of Endothelial Progenitor Cells
Authors: Kishore K Wary, Choun Mock, Sean Garean, Yidan D Zhao, Asrar B Malik
Journal: Circulation (2007)

Endothelial Progenitor Cell (EPC)-based therapy may be useful for the treatment of microvascular disorders associated with ischemic diseases and for therapeutic neovascularization. Here, we addressed whether mouse bone marrow derived EPCs (mEPCs) express integrins, synthesize and deposit fibronectin, requirements for EPC engraftment in injured microvessels. We used anti-CD34, anti-Flk-1, and anti-VE-cadherin antibodies as mEPC markers. Ex vivo expanded mEPCs were analyzed by fluorescent microscopy and Western blotting for expression of integrins, fibronectin, and von Willebrand Factor (ligands for integrins alpha-5 beta-1 and alpha-v beta-3). Fibronectin and vWF expression of mEPCs was compared with adult mouse lung endothelial cells (mECs). Fluorescent microscopy showed markedly increased fibronectin and vWF staining and Western blotting showed &gt;20-fold increase in fibronectin and vWF expression in mEPCs compared with mECs. The appearance of polymerized fibronectin matrix suggested that mEPCs synthesized, deposited, and assembled fibronectin. Next, ex vivo expanded mEPCs were subjected to shRNA-mediated silencing of alpha-5 integrin, fibronectin and vWF genes. Silencing of alpha-5 integrin and fibronectin genes reduced the proliferative potential of mEPCs whereas vWF silencing had no effect. To evaluate the effectiveness of mEPCs treatment, we irradiated C57BL/6J mice (5.0 Gy) and challenged the mice i.p. with bacterial lipopolysaccharide (LPS) to induce endothelial barrier injury and pulmonary edema. Infusion of mEPCs induced greater survival (~50% at 7.5 mg of LPS/kg BW, n=6) and prevented pulmonary edema resulting from microvessel injury; in contrast, mECs infusion had no protective effect. Thus, EPC expression of alpha-5 beta-1 integrin and secretion of fibronectin matrix may be crucial determinants of engraftment of EPCs at sites of vascular injury, and their ability to promote repair of injured microvessels and neovascularization.
A Phase I/II Study of TACI-Ig To Neutralize APRIL and BLyS in Patients with Refractory or Relapsed Multiple Myeloma or Active Previously-Treated Waldenström’s Macroglobulinemia.
Authors: Jean-Francois Rossi, Isabelle Borghini-Fuhrer, Jerôme Moreaux, Guilhem Requirand, Said Bouseida, Marie Picard, Arnaud Ythier, Eric Sievers, Bernard Klein
Journal: Blood (2005)
Dangers of intravenous ritodrine in diabetic patients
Authors: D. Mordes
Journal: JAMA (1982)

Two cases are reported in which administration of ritodrine hydrochloride, a β-2-sympathomimetic agent, was followed by diabetic ketoacidosis when it was used for inhibition of premature labor in insulin-requiring diabetic patients. Ketoacidosis occurred shortly after intravenous ritodrine, despite previous administration of large subcutaneous doses of insulin. Early recognition and treatment of this serious complication are critical for fetal survival. (<i>JAMA</i>1982;248:973-975)
Late recurrence of corticosteroid-responsive nephrotic syndrome of childhood
Authors: J. E. Engle
Journal: JAMA (1980)

CHILDREN with minimal-change nephrotic syndrome usually respond to corticosteroid therapy and eventually enter complete remission before reaching adulthood. Although this disease entity is relatively common in both children and adults, it is extremely rare to encounter adult nephrotic patients who had nephrotic syndrome during childhood. We describe here a patient who had typical minimal-change nephrotic syndrome as a child and, after a corticosteroidinduced complete remission lasting 19 years, had severe nephrotic syndrome as an adult. <h3>Report of a Case</h3> A 26-year-old woman was seen at The Milton S. Hershey Medical Center in March 1977 with edema. In 1953, at the age of 22 months, she had been hospitalized with edema and ascites. Laboratory values at that time had included proteinuria (4+); serum albumin, 1.6 g/dL; BUN, 9 mg/dL; and serum cholesterol, 952 mg/dL. Following the administration of cortisone, 25 mg four times a day for 11 days, she had become
The Medical Defence Union
Authors: A. G. Bateman
Journal: BMJ (1902)

Day-case cataract surgery and the need for local anaesthesia are likely to increase. Retrobulbar (and peribulbar) anaesthetic injection is a common technique in cataract surgery, but serious complications are persistently reported. Subconjunctival injection is an alternative that avoids these risks. This retrospective study compares two groups of patients that underwent extracapsular cataract surgery under local anaesthetic. One group (retrobulbar) had uncomplicated retrobulbar injection with bupivicaine and hyaluronidase. The other group (non-retrobulbar) had superior bulbar, subconjunctival infiltration with bupivicaine and hyaluronidase. The operative complications and postoperative visual outcomes were similar in both groups. These results may encourage the investigation and adoption of the subconjunctival alternative to retrobulbar anaesthetic injection in cataract surgery.
Fallimento de Inoculation con Virus Polyoma de Influer super Carcinogenese Chimic in Muses
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suggestions for the Classification of Oncogenic RNA Viruses
Journal: JNCI Journal of the National Cancer Institute (1966)

Journal Article Suggestions for the Classification of Oncogenic RNA Viruses Get access JNCI: Journal of the National Cancer Institute, Volume 37, Issue 3, September 1966, Pages 395–397, https://doi.org/10.1093/jnci/37.3.395 Published: 01 September 1966
Journal of Experimental Medicine, New York
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erradication of HCV with direct-acting antivirals increased small LDL particle number in SVR48
Authors: Vanesa Bernal Monterde, Diego Casas Deza, Eva Fernandez Bonilla, Silvia Espina, Marta Fernández Esgueva, Ana Martinez-Sapiña, Javier Fuentes, Jose M Arbones Mainar
Journal: Journal of Hepatology (2020)
PHYSIOLOGIC FACTORS IN THE CONQUEST OF HIGH ALTITUDES
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dangers of cardiopulmonary bypass operations.
Authors: Rosalind Maskell, Edward Arnold
Journal: BMJ (1989)

significance.In a recent study urinary tract abnormalities were found in 47% of children investigated as a result of this finding.'Dr Smyth and her colleagues ask for an agreed common approach to the investigation and management of urinary tract infection in children.Until studies of the different investigation protocols are completed, and in view of the variable facilities available, an approach is unlikely to be agreed.It is paramount, however, that recurrent or persistent infection should be promptly detected and appropriately acted upon.I have recently attempted to set out protocols, both for general practitioners and for paediatricians, which, provided that good microbiological facilities are available, may be used to determine pathways of investigation and management appropriate to the individual child.4
Otitis Media
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of physical forces on the reproductive cycle. Council on Scientific Affairs
Journal: JAMA (1984)

The Council on Scientific Affairs is aware that physicians, as well as the public in general, have expressed increasing concerns regarding the possible adverse effects of various physical forces on the reproductive organs. Various channels of public communication report anecdotal episodes of suspected cause-and-effect relationships between various physical elements in the environment and harmful effects on reproduction. Many of these episodes have not been substantiated by acceptable scientific research. However, some reports have appeared in the scientific literature that do document adverse reproductive effects on humans and animals at certain levels of some physical forces. At levels above 3,636 m (12,000 ft), adverse reproductive effects have been observed in men and women, in the conceptus, and in certain species of animals. Hyperthermia in excess of 40 degrees C may affect the man and the conceptus, as well as the reproductive capacity of certain animals. However, adverse effects of hypothermia have been observed only in animals. Ionizing radiation can cause injury to the man, woman, and conceptus and to animals, depending on dose and duration of exposure. There have been no well-documented injurious effects to the human reproductive organs resulting from radiofrequency-microwave radiation, but there have been some reports in animals that attributed untoward reproductive limitations to thermal effects. To date, there have been no reports in the scientific literature to implicate electronic and magnetic fields, gravity and acceleration, noise, optical radiation (UV, visible, infrared, and lasers), ultrasound, or vibration as having harmful effects on reproduction in either humans or animals. There is need for more well-designed and controlled studies to be performed in all of these areas of exposure at maximum-tolerated levels to physical force before it can be determined with certainty that no ill effects will accrue to the reproductive cycle, especially in assessing harmful effects from low-level exposure during long periods of time.
Hepatitis among missionaries in Ethiopia and Sudan. Susceptibles at high risk
Authors: J. D. Frame
Journal: JAMA (1968)

Among a group of 178 adult missionaries in Ethiopia, icteric hepatitis occurred at an annual rate of 5.5%. In another group of 57 adults in Ethiopia, and among 66 adults in Sudan, the annual rates were 3.9% and 2.0%, respectively. The incidence among children tended to be lower. The incidence of hepatitis continued at a high level for many years. As a prophylactic, γ-globulin would have been required for many years, not only for the first few. Not more than 55% appeared likely to develop immunity because of inapparent (anicteric) infection. The rate of second bouts of icteric hepatitis was about one fifth the rate for first attacks. The presence of a cold season in the climate may have contributed to the high incidence of hepatitis in Ethiopia, as compared to Sudan.
Bone cells on microcarrier spheres
Authors: G. A. Howard
Journal: JAMA (1983)

Many of the experiments being done in our laboratory to gain a clearer understanding of bone metabolism require the use of cell culture techniques to examine the effects of ions or hormones on a specific cell population. Unfortunately, however, because the isolated osteoblasts and their precursors are anchorage-dependent cells, it is often difficult to obtain large numbers of these cells by standard tissue culture techniques. In an attempt to overcome these difficulties and thus obtain large numbers of these cells, we have adapted a technique of using microspheres (Superbeads, Flow Laboratories, or Cytodex 1, Pharmacia) to which cells will attach and proliferate. These microspheres are composed of diethylaminoethyl anion exchange groups bound to a dextran matrix. First discovered by van Wezel,<sup>1</sup>and worked into research scale applications by Levine et al,<sup>2</sup>this method offers all of the advantages of suspension cultures for large-scale cultivation of cells, while providing
Brief Review
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ERRATUM
Journal: BMJ (1853)

VACCINATION ACT. At the Petty Sessions on Monday, Wim.l'limsant was charged with having committed wilful and corrupt perjury.The facts of this case, as recapitulated by the Chairman, came before the BenchI at their last meeting, when a woman, the wife of a highly respectable ftrmer, was committed to prison for a week for an offience under the new V'accination Act.Cretliton lhas lately been thje scene of a small pox epidemic.A womuan of Tedbum, who, was ignorantly anxious that her childlren sshould get the disease, sent the present defendant, with her two children, into Crediton, to the house of the person committed last week, who liad a servant there ill with the dis.order.The defendaant took the children, and the wonman re- ferred to tied at hanidkerchiief round the necks of the children, that thley mnighit be inifected, which they accordingly were.For this oflence she was committed to prison.On the occasion of the charge against her being heard, the defendant, -who is nephew to the motlier of tihe chiildren, gave evi(lence, and so perjured himself, thiat it was thioighit pr-oper to chiarge him with that offence.He now alpeared in court, supported between two persons, in a wiretehed andl helpless condition, having every
Looking at vision problems in schoolchildren, infants
Authors: H. Cole
Journal: JAMA (1985)

A triennial seminar sponsored by Research to Prevent Blindness Inc, New York City, emphasizes work under way at the frontiers of ophthalmology. These reports—emphasizing research to benefit infants and children—are from the most recent seminar, held in Washington, DC (<i>JAMA</i>[MEDICAL NEWS] 1984; 252:3086). <b>Do children with</b>subtle visual abnormalities perform less well academically than their peers who have normal ocular function? In an attempt to answer this question, Eugene Helveston, MD, director of pediatric ophthalmology, Indiana University School of Medicine, Indianapolis, and colleagues evaluated the visual health of 1,910 schoolchildren in the first through third grades. The eye examination included acuity at distance and near, refraction, muscle balance, depth perception, color vision, ocular movements, ocular alignment, light reaction of the pupil, and evaluation of the cornea, lens, and retina. In addition, the children were asked to complete several simple performance tests such as writing their name, copying geometric figures,
Reply to Ola Bratt and Anna Öfverholm's Letter to the Editor re: Peter Ström, Tobias Nordström, Henrik Grönberg, Martin Eklund. The Stockholm-3 Model for Prostate Cancer Detection: Algorithm Update, Biomarker Contribution, and Reflex Test Potential. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2017.12.028
Authors: Martin Eklund, Peter Ström, Tobias Nordström, Henrik Grönberg
Journal: European Urology (2018)
Cyclophosphamide plus cisplatin versus cyclophosphamide, doxorubicin, and cisplatin chemotherapy of ovarian carcinoma: a meta-analysis. The Ovarian Cancer Meta-Analysis Project.
Journal: Journal of Clinical Oncology (1991)

Four randomized clinical trials comparing cyclophosphamide plus cisplatin (CP) versus cyclophosphamide, doxorubicin, and cisplatin (CAP) individually failed to show a significant survival difference in the treatment of ovarian carcinoma. However, by pooling 1,194 patients from these trials in a meta-analysis, there is a statistically significant survival benefit for CAP (P = .02); in addition, there is a significant advantage for CAP in frequency of negative second-look laparotomy (CAP, 30%; CP, 23%; P = .01). Because the dose intensity of CAP was greater than CP in three of the trials, it remains unresolved to what extent the benefit of CAP is from greater dose intensity and to what extent it is from the doxorubicin itself. Either interpretation suggests directions for improving the chemotherapy of ovarian carcinoma.
THE DEPARTMENT OF PUBLIC HEALTH.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE EVOLUTION OF THE COLOR SENSE.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal