tbuckley/cabot-search huggingface dataset:
ADJUVANT VACCINES
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABSORPTION OF TUBERCLE BACILLI FROM THE ALIMENTARY TRACT.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4290: Simultaneous inhibition of Atypical Protein Kinase-C and mTOR impedes bladder canSimultaneous inhibition of atypical protein kinase-C and mTOR impedes bladder cancer cell progression of bladder cancer cell progression
Authors: S M Anisul Islam, Rekha S. Patel, Raja Reddy Bommareddy, Tracess P. Smalley, Mildred Acevedo-Duncan
Journal: Cancer Research (2019)

Abstract Despite enormous scientific advancements in cancer treatment, there is still so much to do to combat cancer particularly bladder cancer. Drugs once proved to be effective in treating bladder cancer showed reduced efficacy, hence, cancer recurrence rate is increasing. To overcome this situation, several attempts have been considered such as the development of a new effective drug or modify therapeutic regimens by combining two or more existing drugs. In recent years, atypical protein kinase C (aPKC), a phospholipid-dependent serine/threonine kinase, is considered as a central regulator of various cancer-causing signaling pathways and controls cell cycle progression, tumorigenesis, and metastatic determinant. In addition, the biologically important mammalian target of rapamycin (mTOR) pathway is altered in many cancers including bladder and can stimulate the activation of the aPKC pathway. In this study, we examined whether the concurrent inhibition of aPKC and mTOR using a combination of a novel aPKC inhibitor (ICA-I, an inhibitor of PKC-ι, or ζ-Stat, an inhibitor of PKC-ζ) and rapamycin blocks bladder cancer progression. The cell lines tested were MC-SV-HUCT2 normal bladder and TCCSUP bladder cancer cells. Our observed data showed that the combination therapy induced a significant reduction of human bladder cancer cells’ viability, also, individual treatment of aPKC inhibitor and rapamycin brought a similar effect. Moreover, the concurrent inhibition of aPKC and mTOR retards the metastasis of bladder cancer cells. These findings indicate that the administration of aPKC inhibitor together with rapamycin would be a useful therapeutic option in treating bladder cancer. Citation Format: S M Anisul Islam, Rekha S. Patel, Raja Reddy Bommareddy, Tracess P. Smalley, Mildred Acevedo-Duncan. Simultaneous inhibition of Atypical Protein Kinase-C and mTOR impedes bladder canSimultaneous inhibition of atypical protein kinase-C and mTOR impedes bladder cancer cell progression of bladder cancer cell progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4290.
Book Review The Physiology of Oral Hygiene and Recent Research . 2nd Edition. By Sim Wallace. Size 8 3/4 × 5 1/2 inches. Number of pages VIII + 226. Figures in text 7. Price 10s. 6d. net. London, 1929. Bailliere, Tindall &amp; Cox.
Journal: New England Journal of Medicine (1930)
Exposure to polybrominated biphenyls. Some effects on personality and cognitive functioning
Authors: G. G. Brown
Journal: JAMA (1979)

Twenty-one persons exposed to polybrominated biphenyls (PBB) were compared with hospital volunteers on a battery of tests measuring memory, motor strength and coordination, cortical-sensory perception, personality, and higher cognitive functioning. Patients exposed to PBB were selected for this study only if they had persistent medical complaints. The PBB adipose levels did not correlate with performance on any test in the battery. The two groups did differ on the Minnesota Multiphasic Personality Inventory, suggesting an adjustment reaction with depressive symptoms and somatizing defenses. Persons exposed to PBB were also impaired relative to control subjects on tests of prose recall, short-term memory, concentration, and cognitive flexibility. However, these differences vanished when group differences on education and personality were statistically held constant. The selective admission criteria for this study limit the generalizability of these findings. (<i>JAMA</i>242:523-527, 1979)
PROGRAM ANALYSIS
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 56: Increased Neutrophil Counts and Serum Transforming Growth Factor-beta 1 Levels in an Infant With Autoimmune Neutropenia Who Recovered From Kawasaki Disease
Authors: Seigo Okada, Shunji Hasegawa, Yasuo Suzuki, Midori Wakabayashi, Takuya Ichimura, Hidenobu Kaneyasu, Maiko Shimomura, Kazuhiro Nakamura, Masao Kobayashi, Shouichi Ohga
Journal: Circulation (2015)

Kawasaki disease (KD) is an acute, febrile, and systemic vasculitis that primarily occurs in infants and young children. Although the aetiology is unknown, it is considered that abnormal activation of monocytes/macrophages but not lymphocytes could occur during the acute phase of KD. Neutrophils may have a pivotal role in the pathogenesis of KD as well as the formation of coronary artery lesions (CAL). Primary autoimmune neutropenia (AIN) is a common form of chronic benign neutropenias of childhood. AIN, occuring in infancy, is characterised by persistent severe neutropenia (&lt;500/μL of absolute neutrophil counts [ANC]), detection of the autoantibodies against neutrophil-specific antigens, and 95% of resolution before 4 years of age. There has been only one report on a patient with AIN who developed severe KD after the administration of granulocyte colony-stimulating factor. Here, we describe a 21-month-old female with AIN who developed full-blown KD on severe neutropenia remained. Single dose intravenous immunoglobulin led to a prompt response with defervescence. During the convalescent phase of KD, the patient showed a rapid increase and the following recovery of ANC in concert with the elevated levels of serum transforming growth factor-beta 1, that is one of the representative immunoregulatory cytokines. During hospitalization, echocardiography indicated no evidence of CAL. The pathophysiology of KD and the resolution of autoimmunity were discussed with special reference to the cytokine profiles.
Use of anticonvulsant drugs
Authors: F. E. Dreifuss
Journal: JAMA (1979)

THE PAST decade has seen considerable changes in epilepsy management, to which the introduction of new anticonvulsant drugs has contributed. Unfortunately, the ideal drug, one that is long-acting, nonsedative, well-tolerated, useful against various types of seizures, and without a substantive effect on vital organs, while at the same time restoring the EEG to normal, does not exist. Drugs that have been introduced into the therapy of epilepsy in recent years have tended to have more specific actions against particular seizure types, and this has necessitated a more accurate identification and classification of the epilepsies (Table).<sup>1</sup>Thus, drugs useful against absence seizures are not useful in the treatment of complex partial seizures, which may closely mimic absence seizures, and this mandates the distinction between these different types of seizure phenomenons. The introduction of new drugs has been aided by the development of the science of biostatistics, resulting in improved study
Pertussis vaccine.
Journal: BMJ (1981)

Pertussis vaccineVaccination against whooping cough was the medical topic most in the public eye in the mid 1970s.The story began with journalistic comment on a report' from the Hospital for Sick Children in Great Ormond Street, London, of 36 children with brain damage attributed to pertussis vaccine; public anxiety was fuelled by warnings from medical experts2 3 that the risk of an adverse reaction causing neurological damage might be as high as one in every 10 000 vaccinations.It was little wonder, then, that between 1974 and 1978 vaccine acceptance rates for pertussis fell from around 80(, to 31",, with figures as low as 9",, in some parts of the country.' This calamitous decline in ptublic confidence in the vaccine was not stemmed by reassurances from the Joint Committee on Vaccination and Inlmunisation, and one obvious reason was the lack of reliable data on the incidence of vaccine- related damage.The National Childhood Encephalopathy Study was sct up in 1976 to assess the risks of reurological disorders associated with immunisation in childhood.This week the DHSS has published a report6 from the study giving details of 1000 cases, and a shorter version has been prepared for the BMJby the authors (p 159R).The main conclusions are
BOOK REVIEWS
Authors: N. B. ROSENSHEIN
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BOOK REVIEWS Get access Principles and Practice of Gynecologic Oncology William J. Hoskins , Carlos A. Perez , Robert C. Young , eds. , Philadelphia : J. B. Lippincott , 1992 . 924 pp., illus. $150. ISBN 0-397-51060-8 NEIL B. ROSENSHEIN, M.D. NEIL B. ROSENSHEIN, M.D. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Johns Hopkins Medical Institution600 N. Wolfe St. Baltimore, MD 21205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 23, 2 December 1992, Page 1829, https://doi.org/10.1093/jnci/84.23.1829 Published: 02 December 1992
Factor XII Stimulates ERK1/2 and Akt through uPAR, Integrins, and the EGFR to Initiate Angiogenesis.
Authors: Gretchen Larusch, Fakhri Mahdi, Zia Shariat-Madar, Gregory N Adams, Robert Sitrin, Wanming Zhang, Keith R. McCrae, Alvin H. Schmaier
Journal: Blood (2009)
Official Call to the Officers and Members of the American Medical Association to Attend the Interim Meeting of the House of Delegates in Honolulu, Dec 2 to 5, 1984
Authors: Joseph F. Boyle
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deletion 11q Abnormality in Patients with Chronic Lymphocytic Leukemia (CLL) May Not Have Poor Clinical Outcomes and Bulky Disease (clinical and radiological) At Presentation – Clinical Characteristics of (n=172) Previously Untreated Patients with CLL and del11q Cytogenetic Abnormality.
Authors: Preetesh Jain, Long Xuan Trinh, Ohad Benjamini, Susan Lerner, Xuemei Wang, Alessandra Ferrajoli, Jan A. Burger, Zeev Estrov, William G. Wierda, Hagop M. Kantarjian, Susan O'Brien, Lynne V. Abruzzo, Michael J. Keating
Journal: Blood (2012)
Evidence based indicators are needed for primary care groups
Journal: BMJ (1998)

Nut consumption may protect against heart diseaseAlthough nuts are high in fat, the fatty acids are mostly monosaturated or polyunsaturated, which have beneficial effects on blood lipids.In a large prospective study of women, Hu et al (p 1341) found an inverse association between nut consumption and incidence of coronary heart disease.Women who frequently consumed nuts (>5 times per week) had a significantly lower risk of non-fatal myocardial infarction and fatal coronary disease after accounting for age, smoking, and other known coronary risk factors than women who rarely (never or less than once a month) ate nuts.
Withdrawal of baclofen may cause acute confusion in elderly patients
Authors: F O'Rourke, R Steinberg, P Ghosh, S Khan
Journal: BMJ (2001)

Two week rule for cancer referralsReducing waiting times from diagnosis to treatment might be more effectiveEditor-In their editorial on the two week rule for cancer referrals Jones et al discuss the fact that steps to meet the target for "urgent" referrals have led to a doubling of waiting time for "routine" cases. 1 This is exactly the result we would expect from our calculations modelling waiting times with a Monte Carlo model based on Poisson fluctuations in demand. 2 To sustain a waiting time below two weeks, capacity needs to exceed mean demand by approximately two patients a week for a wide range of values of mean demand.This applies to any appointment, including those for diagnostic and staging procedures, as well as for treatment.Applying this excess capacity to a subgroup of urgent referrals is inherently less efficient than applying it to reduce the waits for all patients.If a fast track for urgent referrals is created by transferring resources from routine cases, this is likely to lead to demand exceeding capacity for routine cases and hence to ever increasing waiting times.These calculations assume that variations are due to random fluctuations in a constant demand, which is an effective model for oncology referrals. 2There is some evidence from dermatology that reductions in waiting times lead to increase in demand, negating the benefit of increased resources. 3t might also apply to referrals for suspected cancer, in which case the extra capacity required will exceed our calculations.This effect should not apply to the number of cases of diagnosed cancer, which will be limited by the incidence of the disease.This suggests that resources may be more effectively targeted at reducing the waiting times from diagnosis to treatment than on reducing the time from referral by a general practitioner to diagnosis.
Methoxyflurane, tetracycline, and renal failure
Authors: E. Y. Kuzucu
Journal: JAMA (1970)

Among 115 patients who had abdominal or thoracic surgery after the administration of methoxyflurane anesthesia, seven received tetracycline hydrochloride immediately before or after the operation. Five of them had increasing levels of blood urea nitrogen (BUN) and serum creatinine. Three patients died, and autopsy of the kidneys showed numerous calcium oxalate crystals. The remaining 108 patients either did not receive any antibiotic or received penicillin, streptomycin sulfate, or chloramphenicol. None of them had postoperative renal failure or significant increase in BUN and creatinine levels. Forty patients received tetracycline after spinal anesthesia without evidence of renal failure postoperatively. It is likely that methoxyflurane and tetracycline, when administered concurrently, may seriously impair renal function leading to death.
(11) Sarcoidosis
Authors: M. Samuel, G.E. Allen
Journal: British Journal of Dermatology (1984)

Journal Article (11) Sarcoidosis Get access M. Samuel, M. Samuel Belfast City Hospital, Belfast Search for other works by this author on: Oxford Academic Google Scholar G.E. Allen G.E. Allen Belfast City Hospital, Belfast Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Pages 55–56, https://doi.org/10.1111/j.1365-2133.1984.tb05281.x Published: 01 July 1984
General practitioners and occupational health professionals
Journal: BMJ (2003)

We have reported that individual clinicians are not as influenced by the presentation of risk in population terms as they are by relative risk (Heller et al, submitted for publication), while others have found that the "number needed to treat" statistic (which also relies on measures of absolute risk) is poorly understood by doctors and lay people. 29 30 It remains for us to examine whether new measures of population impact like PIN-ER-t can be more easily understood and used in health policy related decision making than traditional methods of communicating risk.We are developing a research programme to explore this further.Contributors and sources: The authors work at the Evidence for Population Health Unit, aiming to develop a public health counterpart to evidence based medicine.The measure described here is one of a series of population impact measures developed to use evidence combined with routinely collected data to provide local context to measures of risk and benefit and support public health policy decision making.
Atopic Dermatitis, Contact Dermatitis, Urticaria—A Review of Current Knowledge
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Edition of Nothnagel's Encyclopedia. Diphtheria.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal