tbuckley/cabot-search huggingface dataset:
Meetings of Medical Interest
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterially produced human insulin given therapeutically
Authors: W. A. Check
Journal: JAMA (1981)

In mid-December, five Wichita, Kan, patients with newly diagnosed diabetes became the first humans to be treated with a substance produced by recombinant DNA technology. The five began therapy with insulin produced by bacteria into which the human insulin gene had been introduced. The recombinant insulin (also known as biosynthetic insulin), which is being produced by Eli Lilly and Co, had previously been administered to healthy human volunteers in the United States, Great Britain, Greece, and West Germany and found to be free of toxic effects. Phase II testing of the substance is now being carried out under the supervision of Richard Guthrie, MD, professor and chairman of the Department of Pediatrics at the University of Kansas School of Medicine in Wichita; Arthur Krosnick, MD, of the Mercer Medical Center in Trenton, NJ; and Frederick Whitehouse, MD, a former president of the American Diabetes Association who is with the Henry
Photographisches Praktikum für Mediziner und Naturwissenschaftler.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insurance Medicine.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A clinical prediction rule for delirium after elective noncardiac surgery
Authors: E. R. Marcantonio
Journal: JAMA (1994)

<h3>Objective.</h3> —To develop and validate a clinical prediction rule for postoperative delirium using data available to clinicians preoperatively. <h3>Design.</h3> —Prospective cohort study. <h3>Setting.</h3> —General surgery, orthopedic surgery, and gynecology services at Brigham and Women's Hospital, Boston, Mass. <h3>Patients.</h3> —Consenting patients older than 50 years admitted for major elective noncardiac surgery between November 1, 1990, and March 15, 1992 (N=1341). <h3>Measurements.</h3> —All patients underwent preoperative evaluations, including a medical history, physical examination, laboratory tests, and assessments of physical and cognitive function using the Specific Activity Scale and the Telephone Interview for Cognitive Status. Postoperative delirium was diagnosed using the Confusion Assessment Method or using data from the medical record and the hospital's nursing intensity index. Patients were followed up for the duration of hospitalization to determine major complication rates, length of stay, and discharge disposition. <h3>Results.</h3> —Postoperative delirium occurred in 117 (9%) of the 1341 patients studied. Independent correlates included age 70 years or older; self-reported alcohol abuse; poor cognitive status; poor functional status; markedly abnormal preoperative serum sodium, potassium, or glucose level; noncardiac thoracic surgery; and aortic aneurysm surgery. Using these seven preoperative factors, a simple predictive rule was developed. In an independent population, the rule stratified patients into groups with low (2%), medium (8%, 13%), and high (50%) rates of postoperative delirium. Patients who developed delirium had higher rates of major complications, longer lengths of stay, and higher rates of discharge to long-term care or rehabilitative facilities. <h3>Conclusions.</h3> — Using data available preoperatively, clinicians can stratify patients into risk groups for the development of delirium. Since delirium is associated with a variety of adverse outcomes, patients with substantial risk for this complication could be candidates for interventions to reduce the incidence of postoperative delirium and potentially improve overall surgical outcomes. (<i>JAMA</i>. 1994;271:134-139)
Renal Geology
Authors: Leonard B. Berman
Journal: JAMA (1975)

STONES in the genitourinary tract may go off like the alarm bell in a firehouse or may be discovered accidentally, lurking silently on an x-ray film. This clinical spectrum is, in itself, fascinating. It ranges from a patient ashen and clammy with pain to a smiling and comfortable individual whose history includes nothing related to renal disease. These clinical differences are not related to the size of the stone or the pattern of ureteral peristalsis. They are instead, a reflection of the degree of ureteral distention caused by urine piling up behind an obstruction. Analgesics, not antispasmodics, are the proper therapeutic agents. When the initial excitement is over, the occurrence of a stone is a signal for the clinician to put on his endocrinologist's cap and look for specific, treatable stone-forming disorders. The physicochemical nature of stones, ie, the organic matrix with its crystalline shell, will not be dealt with
Shingles
Authors: Janet M. Torpy
Journal: JAMA (2011)

Shingles Shingles is a painful condition caused by the virus that also causes chickenpox (varicella-zoster virus, or VZV).It affects about 1 million individuals per year in the United States alone.Shingles, also known as herpes zoster, occurs in persons who have already had chickenpox.Most individuals who develop shingles are older than 50 years, have other medical problems (such as cancer), or are immune-suppressed from medications they take (such as steroid medications).The virus (VZV) causing shingles and chickenpox is a type of herpes virus.It is a different herpes virus from the ones responsible for cold sores or for genital herpes.VZV remains in nerve tissue after a person recovers from chickenpox.The virus remains dormant (inactive) until reactivated to cause shingles.The cause of this reactivation is not completely understood.The January 12, 2011, issue of JAMA includes an article about shingles.
Rheumatological Medicine
Authors: A. Bamji
Journal: Annals of the Rheumatic Diseases (1986)

valvular mechanism, are well documented in rheumatoid arthritis.'This patient had been seen one year previously when a popliteal cyst had ruptured, resulting, as it usually does,2 in an acute inflammatory reaction in the calf tissues.Treatment on that occasion consisted of lavage of the knee joint with recovery of a moderate amount of fine fibrinous debris, followed by injection of 50 mg of hydrocortisone with good results.This intervention does not, however, seem to have had any effect in preventing the development of the present suprapatellar collection.
Adolescent Interests. A Study of the Sexual Interests and Knowledge of Young Women.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of Lung Sounds and Gas Trapping in the Study of Airway Mechanics
Authors: David G. Frazer, Louis D. Smith, Leo R. Brancazio, Kenneth C. Weber
Journal: Environmental Health Perspectives (1986)

We have previously shown that gas is trapped in isolated animal lungs and have proposed that this gas-trapping process is related to meniscus formation in the small airways of the lung. The purpose of this investigation was to compare how the lung sound-generation process and the gas-trapping process are related to airway mechanics and each other. Rats were anesthetized, the heart and lungs were removed en bloc and placed in a liquid-filled plethysmograph. Lung sounds were recorded by using a microphone acoustically coupled to the tracheal cannula. The results show that discontinuous lung sounds in the form of crackles occur during lung inflation at the same time gas trapping takes place.
6. Glycemic Targets: <i>Standards of Medical Care in Diabetes—2018</i>
Journal: Diabetes Care (2017)

The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
THE INSIGNIA OF THE ARMY MEDICAL DEPARTMENT.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: Circulation (1971)

Stone N, Klein MD, Lown B: Diphenylhydantoin in the prevention of recurring ventricular tachycardia. Circulation 43: 420, 1971. On page 426, the last sentence should be replaced by the following: If the consistent failure of DPH to prevent VT in the patients studied is generally applicable to VT in other patients with coronary artery disease, it appears improbable that DPH would be suitably effective in the prevention of sudden death from ischemic heart disease due to VT and VF.
Urology
Authors: Gerald W. Chodak
Journal: JAMA (1994)

Last year, the Contempo section on urology discussed several issues involving benign and malignant prostatic disease. Since then interest has further increased, in part because several well-known individuals died of the disease and because new knowledge has been gained. Therefore, revisiting the topic is in order. The diagnosis of carcinoma of the prostate is being made more often, with more than 165 000 cases detected in 1993 and 200000 projected for 1994. A likely explanation is widespread testing for the disease, especially by measuring prostate-specific antigen (PSA). Proponents of this test point to the increased proportion of tumors that are detected while still clinically and pathologically confined to the prostate as the obvious benefit of screening for this disease.<sup>1</sup>A controversy exists, however, about whether screening of asymptomatic men should be recommended. The American Cancer Society and the American Urological Association recommend annual testing beginning at age 50 years,
ABSTRACTS
Authors: Joseph Ross, N Maier, Switzerland Sneix, M Iws Nrrou, George Cartwright, Jean Soulier, Robert Cisodos, M Suas, San Juan, Puerto Rico, Roger Crapts, Wm Valentine, Cal Solomon Estren, Philip Wagley, Oliver Jo, Jan Waldenstr#{246}m, J Patel, B Kocher, M Marshall, T Mcnamara, J Schulte
Journal: Blood (1950)
Inside Front Cover Image, Volume 41, Issue 3
Authors: Fan Xia, Peiqing Liu, Min Li
Journal: Medicinal Research Reviews (2021)

The cover image is based on the Review Article The regulatory factors and pathological roles of autophagy-related protein 4 in diverse diseases: Recent research advances by Fan Xia, Peiqing Liu, and Min Li., https://doi.org/10.1002/med.21772.
Splenic cyst causing hypertension by renal compression
Authors: T. A. Rakowski
Journal: JAMA (1977)

HYPERTENSION caused by renal compression is a phenomenon that has been shown to be dependent on the renin angiotensin system in many cases.<sup>1,2</sup>We have recently seen a young man with hypertension associated with a large splenic cyst that induced unilateral renal compression. Renin production was limited to the compressed kidney, and cure of the hypertension was accomplished by splenectomy. <h3>Report of a Case</h3> A 35-year-old man was noted in 1972 to have persistent hypertension, with diastolic blood pressure in the range of 90 to 110 mm Hg. Therapy with chlorothiazide was begun, and this normalized his blood pressure. In 1974, an intravenous pyelogram showed noticeable displacement of the upper collecting system on the left (Fig 1). The history included an episode of abdominal trauma that occurred during an automobile accident 15 years prior to admission. Abdominal pain at that time was localized to the left upper quadrant and
Imagining the Route
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A prospective phase II/III study of PSMA-targeted 18F-DCFPyL-PET/CT in patients (pts) with prostate cancer (PCa) (OSPREY): A subanalysis of disease staging changes in PCa pts with recurrence or metastases on conventional imaging.
Authors: Jeremy C. Durack, Ajjai Shivaram Alva, Mark A. Preston, Frederic Pouliot, Lawrence Saperstein, Peter R. Carroll, Kenneth J. Pienta, Steven P. Rowe, Akash Patnaik, Stephan Probst, Nancy Stambler, Jessica Jensen, Vivien Wong, Barry A. Siegel, Michael J. Morris
Journal: Journal of Clinical Oncology (2021)

32 Background: Conventional imaging and bone scintigraphy are suboptimal modalities for identifying PCa. PSMA-based imaging is highly promising for PCa detection. 18 F-DCFPyL is a novel PSMA-targeted radiopharmaceutical for positron emission tomography (PET) that may be useful in staging of PCa. The diagnostic performance, detection rate, and potential impact of 18 F-DCFPyL on staging of pts with high- risk PCa have been previously reported. Here we report on the impact of 18 F-DCFPyL on staging of pts with PCa recurrence or metastases on conventional imaging. Methods: 18 F-DCFPyL-PET/CT was evaluated in 117 men with radiologic evidence of local recurrence or metastatic disease on baseline anatomical imaging (CT, MRI) or whole-body bone scintigraphy and in whom at least one lesion was deemed amenable to biopsy. A single dose of 9 mCi (333 MBq) of 18 F-DCFPyL was administered via intravenous injection, followed by PET/CT acquisition 1 to 2 hours thereafter. Based on TNM staging: prostatic (T), pelvic LN (N), extra-pelvic LN (M1a), bone (M1b) and other visceral organs/soft tissue (M1c), 18 F-DCFPyL-PET/CT detection rates including lesion counts were systematically analyzed. Three central, blinded, and independent readers evaluated the 18 F-DCFPyL scans. Results: In this study, 82 (70%) patients had baseline radiographic M1 stage disease (14 patients with M1a, 50 patients with M1b, 18 patients with M1c) and 33 (28%) patients were M0 stage at baseline by central conventional imaging review; two patients were unevaluable. 18 F-DCFPyL-PET/CT up-staged 58% (19/33) of pts from M0 to M1, of whom 91% (10/11) who underwent an extra-pelvic biopsy were confirmed to have M1 disease by pathology, including 9 patients with M1b and 1 patient with M1a. Of the patients who were staged M1 at baseline, 18 F-DCFPyL-PET/CT upstaged 16% (10/64; M1a to M1b or M1c: n = 4; M1b to M1c: n = 6) of pts to a higher M1 sub-stage and down-staged 22% (18/82) to M0. Conclusions: 18 F-DCFPyL-PET/CT identified M1 disease in the majority of patients examined who otherwise had locoregional disease. These data suggest that 18 F-DCFPyL-PET/CT may be a useful tool in properly staging men with both metastatic and nonmetastatic relapsed disease, which could lead to superior treatment paradigms than currently exist using conventional imaging. Clinical trial information: NCT02981368.
Nephrology
Authors: Richard J. Glassock
Journal: JAMA (1985)

Advances in our understanding of nephrologic matters have been occurring at an increasing pace and along several fronts. Regulation of body sodium and fluid economy have always been of particular interest to nephrologists. For many years it has been clear that changes in glomerular filtration rate and aldosterone secretion and/or action cannot entirely account for changes in the way renal sodium is handled in health and disease. Among the additional factors postulated is a natriuretic hormone, but the identity and source of this hormone(s) have proven remarkably elusive. Recent studies, however, have settled on two excellent candidates.<sup>1</sup>One of these is called endoxin, which behaves in a fashion resembling an endogenous digoxin.<sup>2,3</sup>This substance has a molecular weight of less than 500 daltons, is not a peptide, and antigenically cross-reacts with antibodies to the digoxin molecule.<sup>4</sup>The organ or tissue source of endoxin remains unknown, as does
PHLEBOTOMY, AN ANCIENT PROCEDURE TURNING MODERN?
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal