tbuckley/cabot-search huggingface dataset:
Le sympathique cervico-thoracique.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prednisone vs triamcinolone acetonide
Authors: H. L. Arnold
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In their BRIEF REPORT, "Ascorbic Acid and Vitamin B<sub>12</sub>" in this issue ofThe Journal, Newmark et al (p 2319) allege that the vitamin B<sub>12</sub>levels we found in foods were "inaccurate." The Table in their article shows that the allegation is not so, since it rests on comparison of foods we extracted in 1974, which happened to have low vitamin B<sub>12</sub>content, with foods we extracted in 1977, which had average vitamin B<sub>12</sub>content. Their Table also shows that one half of the food vitamin B<sub>12</sub>extractable by the Veterans Administration methods appears to become unextractable (or destroyed) by that method of extraction (and assay) in the presence of 0.5 g of ascorbic acid. Because humans do not add the cyanide or metabisulfite of the Association of Official Analytical Chemists (AOAC) and British assay methods to their food to extract the
Hazard ratios
Authors: P. Sedgwick, L. Marston
Journal: BMJ (2010)

Previous questions described survival (time to event) data.1 2 The example used was a randomised controlled trial, which compared the effectiveness of an integrated care programme with usual care in facilitating the return to work for patients with chronic low back pain.3 The integrated care programme was a combined patient and workplace directed intervention. Trial participants were adults aged 18-65 years, who had had low back pain for more than 12 weeks, were in paid work, and were absent or partially absent from work. The primary outcome was duration of time off work after randomisation until a fully sustained return to work. Trial participants were followed for 12 months (figure⇓). Integrated care was more effective than usual care in reducing disability and facilitating a return to work (hazard ratio 1.9, 95% confidence interval 1.2 to 2.8). Kaplan-Meier survival curves for the integrated and usual care interventions of the time until a fully sustained return to work for patients with chronic low back pain Which of the following, if any, are true?
Crystal-induced arthropathy. Gout and pseudogout
Authors: D. Resnick
Journal: JAMA (1979)

CURRENTLY, there are two well-known articular disorders associated with abnormal accumulation of crystals within the joint. In one, gout, clinical abnormalities generally antedate roentgenographic findings by many years, and the roentgenograms serve primarily to record the extent of disease and its response to therapy; in the second, calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, roentgenographic analysis may allow accurate diagnosis in patients who demonstrate nonspecific symptoms and signs or, in some cases, who are entirely asymptomatic. This report emphasizes characteristic roentgenographic findings in both of these crystal-induced disorders and discusses important considerations in the differential diagnosis of these conditions from other articular diseases. <h3>Gout</h3> Although roentgen alterations may accompany the initial bouts of gouty arthritis, the roentgenographic evaluation of most patients with clinical evidence of gout spanning many years will show no important changes. After years of intermittent episodic arthritis, chronic tophaceous gout may develop in association with permanent roentgenographic
Too Many Sidelined by COPD
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment
Authors: Jonathan Pearson-Stuttard, Bin Zhou, Vasilis Kontis, James Bentham, Marc J Gunter, Majid Ezzati
Journal: The Lancet Diabetes & Endocrinology (2018)

BackgroundDiabetes and high body-mass index (BMI) are associated with increased risk of several cancers, and are increasing in prevalence in most countries. We estimated the cancer incidence attributable to diabetes and high BMI as individual risk factors and in combination, by country and sex.MethodsWe estimated population attributable fractions for 12 cancers by age and sex for 175 countries in 2012. We defined high BMI as a BMI greater than or equal to 25 kg/m2. We used comprehensive prevalence estimates of diabetes and BMI categories in 2002, assuming a 10-year lag between exposure to diabetes or high BMI and incidence of cancer, combined with relative risks from published estimates, to quantify contribution of diabetes and high BMI to site-specific cancers, individually and combined as independent risk factors and in a conservative scenario in which we assumed full overlap of risk of diabetes and high BMI. We then used GLOBOCAN cancer incidence data to estimate the number of cancer cases attributable to the two risk factors. We also estimated the number of cancer cases in 2012 that were attributable to increases in the prevalence of diabetes and high BMI from 1980 to 2002. All analyses were done at individual country level and grouped by region for reporting.FindingsWe estimated that 5·7% of all incident cancers in 2012 were attributable to the combined effects of diabetes and high BMI as independent risk factors, corresponding to 804 100 new cases. 187 600 (24·5%) of 766 000 cases of liver cancer and 121 700 (38·4%) of 317 000 cases of endometrial cancer were attributable to these risk factors. In the conservative scenario, about 4·5% (629 000 new cases) of all incident cancers assessed were attributable to diabetes and high BMI combined. Individually, high BMI (544 300 cases) was responsible for almost twice as many cancer cases as diabetes (293 300 cases). 25·8% of diabetes-related cancers (equating to 75 600 new cases) and 31·9% of high BMI-related cancers (174 040 new cases) were attributable to increases in the prevalence of these risk factors from 1980 to 2002.InterpretationA substantial number of cancer cases are attributable to diabetes and high BMI. As the prevalence of these cancer risk factors increases, clinical and public health efforts should focus on identifying optimal preventive and screening measures for whole populations and individual patients.FundingNIHR and Wellcome Trust.
Handbuch der inneren Sekretion: Eine Umfassende Darstellung der Anatomie, Physiologie und Pathologie der endokrinen Drüsen. Lieferung 5, Band I.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-Altitude Pulmonary Edema and Patent Foramen Ovale
Authors: Christoph Dehnert, Peter Bärtsch, Ekkehard Grünig, Derliz Mereles
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Benign Mycoclonus
Authors: James J. Gilbert
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Myoclonus, rapid unpredictable jerking or twitching of one or more muscle groups, is generally a finding associated with significant disease of the central nervous system, most commonly either epilepsy or a progressive degenerative disorder. However, a benign form of myoclonus does exist and perhaps it would be of interest to present briefly a patient with a 50-year history of severe myoclonus and no other neurologic abnormalities. <h3>Report of a Case.—</h3> A 75-year-old man was seen in the Neurology Clinic at the Boston Veterans Administration Hospital with a history of "jerking of my arms and head since 1918." Examination revealed peculiar rapid, flailing movements of both arms and, to a lesser extent, the head. These occurred about once every 30 minutes, and on some occasions the patient would strike his chest or face during one of these movements. They occurred at rest and did not represent action myoclonus,
PORTABLE COMPRESSED AIR APPARATUS AND NASAL SAW.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Looking at Cancer
Authors: J. W. Berg
Journal: CA A Cancer Journal for Clinicians (1961)

The life history of cai-cinoids.the most common neoplasms of the small intestine, is descr'ihed by Moei-tel et al.While the major-ity of these tuniors were silent and found incidentally at autopsy, about 25% were symptomatic and tr-eated surgically, Any r-esidual doubts concerning malignancy of these tumor-s vanishes with the observation that the metastatic i-ate was 86@ in the symptoniatic cases.It was a peculiar', indolent malignancy, however, for-despite liver' involvement in almost hall' the patients with metastases, the 5-year' sui'vival i-ate was 50@, and 27@ of the patients with inoperable lesions survived five year's!Pi'eoperative diagnosis is difficult because of the vai-ied and nonspecific symptoms.The car-cinoid syndr-ome occurred in 7@ of the patients; all but two of these 14 had liver metastases at the time.
Lewisite
Authors: Sage W. Wiener
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of high-fat meal on coronary flow reserve in young healthy men; Noninvasive assessment by transthoracic doppler echocardiography with a high-frequency transducer Takeshi Hozumi, Marc S. Eisenberg, Kenichi Sugioka, Aravind R. Kokkirala, Ali Fard, Hiroyuki Watanabe, Takashi Muro, Masakazu Teragaki, Kazuhide Takeuchi, Marco Di Tulio, Junichi Yoshikawa, Shunichi Homma. Columbia University, New York, NY, Osaka City University Graduate School of Medicine, Osaka, Japan
Journal: Journal of the American College of Cardiology (2001)
Characterization of Inducible Nitric Oxide Synthase Expression in Human Airway Epithelium
Authors: Fuhua H. Guo, Serpil C. Erzurum
Journal: Environmental Health Perspectives (1998)

Nitric oxide is an important mediator of inflammatory responses in the lung and a key regulator of pulmonary vascular and bronchomotor tone.We have shown that the inducible nitric oxide synthase (iNOS) isoform is continuously expressed in human airway epithelium at mRNA and protein/activity levels in vivo.However, removal of epithelial cells from the in vivo airway environment resulted in rapid loss of iNOS expression, which suggested that expression is dependent upon conditions and/or factors present in the airway.To investigate the mechanisms responsible for maintenance of expression in vivo, we evaluated regulation of iNOS expression in primary human airway epithelial cells.Interferon-y (IFNI' was sufficient for induction of iNOS in primary human airway epithelial cells (HAEC) in vitro, and interleukin-4 (IL-4) potentiated the expression through stabilization of iNOS mRNA.The IFN-y/IL-4-induced iNOS expression in HAEC was delayed in onset and prolonged with expression up to 1 week.Furthermore, transfer of overlying culture media [conditioned media (CM)] to other HAEC led to iNOS induction.Interestingly, IFN-y/IL-4 induction of iNOS was dependent on new protein synthesis, whereas CM induction of iNOS was not.IFN-,y and IL-4 activated signal transducers and activators of transcription (STAT1 and STAT6) in HAEC, but CM transfer to HAEC produced even higher levels of STAT1 activation than achieved by direct addition of cytokines.Thus, IFN-y/IL-4, which occurs in human lung lining fluid, led to iNOS expression in human airway epithelium through production of soluble mediators and stabilization of mRNA.
Contraindications to liver transplantation
Authors: Roy Calne
Journal: Hepatology (1994)

For someone dying of liver disease, the most valuable gift of all is a functioning liver transplant.The requirements to carry out a successful liver grafting operation are expensive and consume health care resources that, in every country, are limited.The donation of organs can only occur where the general public understands the principles of the procedure and is happy with selection of recipients, that the best possible use is made of organs and that the recipients selected are deserving.A patient in need of an organ graft receives such a gift as a privilege, not a right, and it is also a privilege for the donor to make the gift.The contraindications to liver grafting must be fully understood by the medical profession.They fall into two categories: (a> absolute and (b) relative. Absolute Contraindications. A patient with a fatal
PYRETHRUM DERMATITIS.
Authors: H. G. ADAMSON
Journal: British Journal of Dermatology (1936)

British Journal of DermatologyVolume 48, Issue 12 p. 668-669 PYRETHRUM DERMATITIS. H. G. ADAMSON, H. G. ADAMSONSearch for more papers by this author H. G. ADAMSON, H. G. ADAMSONSearch for more papers by this author First published: December 1936 https://doi.org/10.1111/j.1365-2133.1936.tb15550.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume48, Issue12December 1936Pages 668-669 RelatedInformation
Abstract 4435: Molecular mechanism of a novel covalent allosteric inhibitor of SUMO E1 activating enzyme
Authors: Zongyang Lyu, Lingmin Yuan, Katelyn M. Williams, James H. Atkison, Shaun K. Olsen
Journal: Cancer Research (2019)

Abstract Post-translational modification of proteins by ubiquitin and ubiquitin-like proteins (collectively termed Ubls) proceeds through the sequential interactions and activities of parallel cascades of enzymes that are structurally and mechanistically related. E1 enzymes initiate Ub/Ubl conjugation cascades by catalyzing the ATP-dependent activation and transfer of their cognate Ub/Ubl to E2-conjugating enzymes, which then function with an array of E3 ligases to catalyze the formation of an isopeptide bond linking the Ub/Ubl to target proteins. Aberrations in Ub/Ubl modifications are associated with the pathogenesis of a wide range of life-threatening diseases, which has resulted in several Ubl E1 enzymes emerging as attractive targets for the development of small molecule therapeutics. We present the crystal structure of the E1 enzyme for the Ubl SUMO in complex with a small molecule representing a new class of Ubl E1 enzyme inhibitor. The structure reveals that the covalent allosteric inhibitor targets a cryptic pocket distinct from the active site that is completely buried in all previous SUMO E1 structures and that inhibitor binding is accompanied by a network of structural changes that altogether lock the enzyme in a previously unobserved inactive conformation. Altogether our studies provide the molecular mechanisms of inhibition SUMO E1 specificity and establishes a framework for the development of molecules targeting other Ubl E1s at a newly discovered cryptic allosteric site. Supported by NIH R01GM115568, F30CA216921, T32CA193201, and a Hollings Cancer Center Postdoctoral Fellowship. Citation Format: Zongyang Lyu, Lingmin Yuan, Katelyn M. Williams, James H. Atkison, Shaun K. Olsen. Molecular mechanism of a novel covalent allosteric inhibitor of SUMO E1 activating enzyme [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4435.
Acute organic brain syndrome associated with gentamicin therapy
Authors: G. J. Byrd
Journal: JAMA (1977)

Two patients receiving gentamicin sulfate experienced acute organic brain syndromes that subsided after use of the drug was discontinued. Among the various factors considered as possible causes, time sequences point to gentamicin as the most likely. (<i>JAMA</i>238:53-54, 1977)
Retraction Notice to: The Ubiquitin Ligase Mul1 Induces Mitophagy in Skeletal Muscle in Response to Muscle-Wasting Stimuli
Authors: Sudarsanareddy Lokireddy, Isuru W. Wijesoma, Serena Teng, Sabeera Bonala, Peter D. Gluckman, Craig McFarlane, Mridula Sharma, Ravi Kambadur
Journal: Cell Metabolism (2015)
EVALUATION OF SKIN GRAFT VIABILITY USING XE-133 SALINE CLEARANCE RATES.
Authors: Stephen R. Bunker, Jaykumar C. Patel, Thomas E. Smith, Michael F. Hartshorne, Robert D. Karl, Michael A. Cawthon, William H. Howard
Journal: Clinical Nuclear Medicine (1983)

Bunker, Stephen R.; Patel, Jaykumar C.; Smith, Thomas E.; Hartshorne, Michael F.; Karl, Robert D. Jr.; Cawthon, Michael A.; Howard, William H. III. Author Information