tbuckley/cabot-search huggingface dataset:
THE MERCURIALS.
Authors: S. V. CLEVENGER
Journal: JAMA (1896)

<h3>Calomel.</h3> —Adopting Schmidt's<sup>12</sup>analysis of pancreatic juice, I found that it required 21 grams (323grs.) of the official hydrochloric acid to neutralize 143 grams (2200 grs.) of this artificial pancreatic juice. The proportion was as 1 to 7. One part of hydrochloric acid will neutralize one and one-half parts of potassium hydrate. Then the alkalinity of pancreatic juice is to potassium hydrate as 7 to 1.5, or it requires 4.6 times as much pancreatic juice as caustic potash to neutralize the same weight of muriatic acid. Schmidt's quantities being parts of 1,000, I am thus enabled to place the alkalimety of pancreatic juice at 4.6 parts per 1,000, which agrees remarkably with Matteucci's estimate of the lymph and chyle alkalinity being equivalent to 4.3 parts per 1,000, in terms of potassium hydrate. Bidder and Schmidt estimated the amount of pancreatic fluid daily secreted by man as 7 ounces (224
Abstract 675: Network modeling of drug resistance mechanisms and drug combinations in breast cancer
Authors: Jorge Gómez Tejeda Zañudo, Pingping Mao, Joan Montero, Guotai Xu, Kailey J. Kowalski, Gabriela N. Johnson, José Baselga, Maurizio Scaltriti, Anthony G. Letai, Nikhil Wagle, Reka Albert
Journal: Cancer Research (2019)

Abstract Durable control of invasive solid tumors is thwarted by the lack of knowledge of effective drug combinations and of the acquired and intrinsic resistance mechanisms of drugs. In an effort to tackle this problem, the SU2C-NSF-TVF Drug Combination Convergence Team is using mechanistic models of cancer cell signaling based on therapeutic and cell line data in order to identify elements within cancer cells that might eventually be exploited through therapeutic combinations. Here we present a comprehensive mechanistic network model of signal transduction in ER+ PIK3CA-mutant breast cancer. Focusing on PI3K inhibitors, the model recapitulates known resistance mechanisms and predicts other possibilities for resistance: loss of RB1, FOXO3, P27, or PRAS40. To test these predictions, we analyzed genome-wide CRISPR screens of two breast cell lines in the presence of PI3K inhibitors (BYL719 and GDC0032) and found that the predicted genes (RB1, FOXO3, P27, and PRAS40) were significantly enriched in the screens. Some of these resistance genes (e.g. loss of RB1) were found to be cell-line specific and follow-up experiments in RB1-KO cells confirmed the cell-line-specific nature of PI3K-inhibitor resistance. The model also reveals known and novel combinatorial interventions that are more effective than PI3K inhibition alone. For example, the model predicts that the combination of PI3K inhibitors with inhibitors of anti-apoptotic protein MCL1 would be effective. Follow up experiments in cell lines using cell viability assays, cell death analyses, and dynamic BH3 profiling experiments to determine increases in apoptotic priming upon treatment confirmed that MCL1 inhibitors (S63845) enhance the effect of PI3K inhibitors (BYL719) and that this combinatorial effect is cell-line-specific, similarly to what was found in the resistance genes case. In conclusion, the model predicted drug resistance mechanisms and effective drug combinations, some of which were verified experimentally and found to be cell-line-specific. Next iterations of the model will incorporate the identified discrepancies and newly identified resistance mechanisms to drugs of clinical interest. Citation Format: Jorge Gómez Tejeda Zañudo, Pingping Mao, Joan Montero, Guotai Xu, Kailey J. Kowalski, Gabriela N. Johnson, José Baselga, Maurizio Scaltriti, Anthony G. Letai, Nikhil Wagle, Reka Albert. Network modeling of drug resistance mechanisms and drug combinations in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 675.
<i>Notice to Readers:</i> Ongoing Analysis of Suicide Rates Data by Occupational Group from Results Reported in <i>MMWR</i>
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Recently, MMWR Editors were informed by the authors of "Suicide Rates by Occupational Group -17 States, 2012" (1) that some results and conclusions might be inaccurate as a result of coding errors for certain occupational groups.The authors are undertaking a thorough reanalysis of the data.This notice is to alert readers about the coding errors while the reanalysis is conducted to assess the validity of results and conclusions in the publication.
Antitussives in jeopardy
Authors: W. R. Barclay
Journal: JAMA (1973)

In the<i>Federal Register</i>, Feb 9, 1973, the Food and Drug Administration (FDA) published a notice to withdraw from the market certain antitussive combinations. Named in the withdrawal notice are the following preparations: Novrad With ASA Coricidin With Codeine Phosphate Phenergan Expectorant With Codeine Phenergan Expectorant Phenergan VC Expectorant Phenergan VC Expectorant With Codeine Pediatric Phenergan Expectorant Phenergan Expectorant Troches Phenergan Expectorant Troches With Codeine Dimetane Expectorant Dimetane Expectorant-DC Omni-Tuss suspension Tussionex tablets Ulogesic tablets Ulominic Syrup Coditrate Syrup Methajade liquid Thephorin Expectorant Actifed-C Expectorant Clistin Expectorant Tuss-Ornade liquid Tuss-Ornade Spansules Benylin Expectorant Ambenyl Expectorant Cothera Compound Pyribenzamine Expectorant Pyribenzamine Expectorant With Codeine and Ephedrine However, other products of similar compositions will also be affected even though they are not specifically cited. The FDA is basing this action on regulations established by the 1962 Harris-Kefauver amendments to the Food, Drug, and Cosmetic Act of 1938 and on the National Academy
Phenotypic characterization of Lith genes determining susceptibility to cholesterol (Ch) gallstone formation in inbred mice Brigham and Women's Hospital, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA; and The Jackson Laboratory, Bar Harbor, ME
Journal: Hepatology (1995)

Previous studies have reported an association between vitamin D receptor (VDR) gene polymorphisms and Parkinson's disease (PD), but the results were controversial. To explore whether VDR gene polymorphisms have an effect on PD risk, we performed this meta-analysis to evaluate the association between three VDR gene polymorphisms (Bsml, Apal, Taql) and PD susceptibility. We performed a systematic literature search for articles published up to February 2014 in multiple databases and selected seven eligible studies. Four studies were included for each polymorphism. Odds ratios (ORs) as well as their corresponding 95% confidence intervals (CIs) were used to estimate the association between VDR gene polymorphisms and PD risk in four phenotype models. Subgroup analysis and publication bias were also performed. Heterogeneity analysis and sensitivity analysis were performed if necessary. We failed to detect any association between Apal, Bsml, Taql polymorphisms and PD susceptibility in all four genetic models. In subgroup analysis grouped by ethnicity, no significant association was detected. The present meta-analysis indicates that the VDR genetic polymorphisms Bsml, Apal and Taql are not associated with susceptibility to PD. Because of the limited number of included studies, the results should be cautiously interpreted. More carefully designed studies are needed to verify our results.
PREVENTING TUBERCULOSIS AT ITS FOUNTAINHEAD
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WHY SHOULD WE ESTIMATE FOR UREA?
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Chronic Fatigue Syndrome
Authors: Edward B. Rotheram Jr.
Journal: Annals of Internal Medicine (1995)

Letters1 July 1995The Chronic Fatigue SyndromeEdward B. Rotheram Jr., MDEdward B. Rotheram Jr., MDMedical College of Pennsylvania; Allegheny General Hospital; Pittsburgh, PA 15212Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-1-199507010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As a potential investigator into the mysteries of the chronic fatigue syndrome, I need some clarification of the revised case definition provided by Fukuda and colleagues [1]. If a patient relates fluently, for more than an hour, the minute details of his or her medical history, how should I assess his or her reports of defective memory, poor concentration, and difficulty in communication? If, during the interview, a patient moves easily about in a chair, walks effortlessly to the examination room, disrobes quickly, and hops (despite being 80 pounds overweight) onto the examination table, how should I ...REFERENCE1. Fukuda K, Strauss SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A, and the International Chronic Fatigue Syndrome Study Group. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994; 121:953-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Medical College of Pennsylvania; Allegheny General Hospital; Pittsburgh, PA 15212 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMit chronischem Müdigkeits- bzw. Fibromyalgie- syndrom assoziierte Manifestationen: Ausdruck einer Dysbalance im neuroendokrinoimmunologischen Regelkreis? 1 July 1995Volume 123, Issue 1Page: 74-76KeywordsChronic fatigue syndromeFatigueLymph nodesMemoryMusclesMyalgiaOverweightPharynxStormsUltrasound imaging ePublished: 15 August 2000 Issue Published: 1 July 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Our Journal.
Authors: Richard C. Newton
Journal: JAMA (1896)

Montclair, N. J., June 7, 1896. <h3>To the Editor:</h3> —I have just voted to move the publication office of theJournalto Washington, D. C., and was actuated by the following reasons: 1. TheJournalis the organ of a great national Association which should know no local prejudice nor be controlled by any local body of men. 2. Any serial publication must in some measure respond to the influence of its environment, therefore, in the case of a periodical whose aims are so broad and whose spirit must be so catholic as those which theJournalmust display, unless it shall fail of its high mission, its seat of publication should be the most cosmopolitan possible. 3. Washington is the most cosmopolitan city in this country. It can have, from the nature of its institutions and government, no strong local prejudices. 4. It is, furthermore, the center of scientific
Prevention of travelers' diarrhea by the tablet formulation of bismuth subsalicylate
Authors: H. L. DuPont
Journal: JAMA (1987)

Within 48 hours of arrival in Mexico, 182 US students participated in a study to compare the efficacy of two dosages of bismuth subsalicylate (262 mg per tablet) as a prophylactic agent against diarrhea. The students were randomly assigned to receive two tablets (high dose) or one tablet (low dose) of bismuth subsalicylate four times daily or a placebo four times daily during a three-week period. Among these completing the trial, diarrhea (four or more unformed stools in 24 hours or three in eight hours, plus one other symptom) occurred in seven (14%) of 51 receiving the high-dose regimen compared with 15 (24%) of 63 receiving the low-dose regimen and 23 (40%) of 58 in the placebo group. Protection rates were 65% for high-dose and 40% for low-dose bismuth subsalicylate. Diarrhea caused by enterotoxigenic Escherichia coli was found in one student receiving the high-dose regimen, in no students receiving the low-dose regimen, and in seven placebo-treated subjects. Bismuth subsalicylate was well tolerated; the most common side effects were blackening of tongues and stools. Bismuth subsalicylate use in both dosages was associated with tinnitus at a low, clinically insignificant frequency of 1.2 days per 100 days of treatment. The dosage of two tablets of bismuth subsalicylate four times daily (2.1 g/d) appears to be a safe and effective means of reducing the occurrence of travelers' diarrhea among persons at risk for periods up to three weeks. (<i>JAMA</i>1987;257:1347-1350)
Amphetamine Prescribing
Authors: W. O. McCormick
Journal: BMJ (1967)

The major objection to the theory has been that by light microscopy the renal glomeruli may appear normal in acute renal failure.Nevertheless, the main functional defect appears to be glomerular.2Price and Palmer,3 who also quote Goormatigh, did find histological changes in the glomeruli in acute renal failure, and Koffler and Paronetto4 have now shown that immunofluorescence can reveal diffuse deposits of fibrinogen outlining the capillary loops of glomeruli that look otherwise normal and give negative P.T.A.H. and Lendrum staining.I have recently started to study the turnover of 131I fibrinogen with which I obtain a normal half-life for "'I-clottable protein of 2.5 to 4 days.So far only two cases of acute renal failure have been studied: one case of postpartum anuria gave a half-life of 1.4 days and another case of acute renal failure investigated rather late after the onset gave a value of 2.5 days.One should not suppose that other factors are not involved in the pathogenesis of acute renal failure, such as the liberation of serotonin from damaged platelets, or that once acute tubular necrosis has occurred as a result of the initial impairment of the circulation oliguria may not persist perhaps by leakage of glomerular filtrate back through damaged tubular cells, occasioned by the osmotic pressure of blood in the peritubular capillaries.Nevertheless, the time has come for more centres to be interested in these types of investigation, and, moreover, for there to be a reappraisal of the use of heparin in acute renal failure.Another important con- sideration is that haemodialysis with inade- quate heparinization may not only cause defibrination but add to shunt blockage.-Iam, etc.,
Communications problems affecting patient care in hospitals
Authors: J. C. Quint
Journal: JAMA (1966)

Medical services in large hospitals are organized to make available the most advanced diagnostic and therapeutic techniques for patient treatment; they are not, however, organized to provide opportunities for direct communications among physicians, patients, and nursing staff. Yet the need for such communications increases with continuing technological changes, increasing medical specialization, and complexity of treatments. <h3>Organizational Factors.—</h3> In the modern hospital, medical care is a complicated process which involves physicians in a heavy schedule of patient rounds, diagnostic conferencss, and consultations with other physicians. In teaching hospitals, particularly, each specialty section is concerned not only with research and the care of patients, but also with training members of the house staff and with teaching and supervising medical students. In effect, medical services in hospitals used for teaching are organized to achieve multiple aims, and the work is accomplished through a complex network of individuals with dissimilar amounts of experience and
National Standards for Diabetes Self-Management Education
Authors: Martha M. Funnell, Tammy L. Brown, Belinda P. Childs, Linda B. Haas, Gwen M. Hosey, Brian Jensen, Melinda Maryniuk, Mark Peyrot, John D. Piette, Diane Reader, Linda M. Siminerio, Katie Weinger, Michael A. Weiss
Journal: Diabetes Care (2011)

iabetes self-management education (DSME) is a critical element of care for all people with diabetes and is necessary in order to improve patient outcomes.The National Standards for DSME are designed to define quality diabetes self-management education and to assist diabetes educators in a variety of settings to provide evidence-based education.Because of the dynamic nature of health care and diabetes-related research, these Standards are reviewed and revised approximately every 5 years by key organizations and federal agencies within the diabetes education community.A Task Force was jointly convened by the American Association of Diabetes Educators and the American Diabetes Association in the summer of 2006.Additional organizations that were represented included the American Dietetic Association, the Veteran's Health Administration, the Centers for Disease Control and Prevention, the Indian Health Service, and the American Pharmaceutical Association.Members of the Task Force included a person with diabetes; several health services researchers/ behaviorists, registered nurses, and registered dietitians; and a pharmacist.The Task Force was charged with reviewing the current DSME standards for their appropriateness, relevance, and scientific basis.The Standards were then reviewed and revised based on the available evidence and expert consensus.The committee convened on 31 March 2006 and 9
Abstract 1268: Small Molecule Targeting Of gβγ Reduces β-adrenergic Receptor Desensitization And Normalizes Cardiac Dysfunction In An Acute Heart Failure Model
Authors: Liam Casey, Frances Nwakanma, Gabriel Vorobiof, Olga Dunaevsky, Alan V Smrcka, Burns C Blaxall
Journal: Circulation (2007)

Heart failure (HF) is a debilitating disease with poor prognosis, despite substantial therapeutic advances in the past two decades. Excess signaling through cardiac G-protein Gβγ subunits is an important component of HF pathophysiology. They recruit elevated levels of cytosolic G-protein coupled receptor kinase 2 (GRK2, a.k.a. βARK1) to agonist-stimulated β-ARs in HF, leading to chronic β-AR desensitization and down-regulation; these events are all hallmarks of HF. Previous data has suggested that inhibiting Gβγ signaling and its interaction with GRK2 could be of therapeutic value in HF. We recently developed a novel small molecule targeting strategy to selectively inhibit Gβγ binding interactions, and identified several Gβγ inhibitory small molecules (Bonacci et al, Science, 2006). In particular, we identified compound M119, which blocked the interaction of purified Gβγ and GRK2 in vitro. To validate this activity in a cellular setting, we isolated adult mouse cardiomyocytes, where M119 significantly reduced β-AR-mediated membrane recruitment of GRK2. Furthermore, M119 significantly enhanced both adenylyl cyclase activity and cardiomyocyte contractility at baseline and in response to β-AR agonist stimulation. Upon finding that the compound was biologically available following intraperitoneal injection in mice, we investigated whether the observed in vitro effects in isolated adult cardiomyocytes would translate to in vivo effects on cardiac function. Initial investigations were pursued in an acute pharmacologic HF model (30 mg/kg/day isoproterenol for seven days). Importantly, concurrent once daily injections of M119 normalized cardiac function, morphology and GRK2 expression in this acute HF model. Collectively, our study has identified a small molecule Gβγ inhibitor capable of reducing β-AR desensitization, thereby enhancing β-AR-mediated isolated cardiomyocyte contractility and, importantly, normalizing cardiac function and morphology in an acute HF model in vivo. Our data suggest a promising therapeutic role for small molecule inhibition of Gβγ in the treatment of HF.
The American National Red Cross. Its Origin, Purposes, and Service.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal