tbuckley/cabot-search huggingface dataset:
Risk Calculations for HIV Transmission From Infected Health Care Workers
Authors: Ronald K. St. John
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Von Reyn et al<sup>1</sup>have underestimated the upper limit of the 95% CI (0 to 4.37/100 000 patients). The conclusions of von Reyn et al minimize the risk. Nevertheless, the finding of 0% prevalence among patients recalled and tested in their article and in the companion articles<sup>2,3</sup>is reassuring. Based an the binomial model, when testing a sample representing 50.7% of the study population (1174 tested of 2317 potentially exposed patients), the chance that there is one positive individual who is not included in the sample is high (50.2%). This probability is precisely calculated by the following: (1-1/n)<sup>0.507n</sup>, where<i>n</i>is the population size (2317). If one HIV-infected patient was missed, then the sero-prevalence in this population would be 4.3 per 10 000 patients (1/2317), or 10-fold higher than the 95% upper CI of von Reyn et al. At the critical 0.05 confidence level,
Two Consultations
Authors: James A. Cowan
Journal: JAMA (1986)

After finishing at my office, I went to the hospital to see two patients in consultation. It was 5:45 PM when I got to the nursing station on 3 South and pulled Mr Roberts' chart from the rack. 3 South looked like any busy medical floor at the end of the day. There was a smell of food, and disheveled supper trays could be seen in patients' rooms. A few early-evening visitors were hesitantly searching for room numbers or talking softly at the bedside. I took the chart to a small cubicle used by physicians for dictating, made a call to the intensive care unit, and then opened the chart. Mr Roberts had been admitted five weeks earlier with complaints of abdominal pain and vomiting of blood. The pain had been present for some weeks, but he first vomited blood on the day of admission. I knew and trusted the
Plasmapheresis Therapy in Macroglobulinemia.
Authors: A. Solomon
Journal: Annals of Internal Medicine (1962)

s1 April 1962Plasmapheresis Therapy in Macroglobulinemia.A. Solomon, M.D., J. L. Fahey, M.D.A. Solomon, M.D.Search for more papers by this author, J. L. Fahey, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-690_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA marked increase in serum viscosity may be responsible for many of the disease manifestations of pathologic states associated with elevated serum macroglobulin levels. For this reason, rational therapy was directed at reduction of serum viscosity and macroglobulin level.Schwab and Fahey (New Engl. J. Med. 263: 574, 1960) have reported the beneficial effect of plasmapheresis in two patients with Waldenström's macroglobulinemia. Current evaluation of the therapeutic usefulness of plasmapheresis is based on observations in ten patients with macroglobulinemia. Many disease manifestations including bleeding diathesis, visual disturbance and retinal hemorrhages, vertigo and other neurological symptoms, and cardiac limitations were reversed... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. Solomon, M.D.; J. L. Fahey, M.D.Affiliations: Bethesda, Md. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 690-691KeywordsHeart diseasesHemorrhageVertigo ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...
"USE OF HOLLOW TUBE FOLLOWING SUBMUCOUS RESECTION OF THE NASAL SEPTUM"
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the Chemistry and Therapeutics of Uric Acid Gravel and Gout, being the Croonian Lectures for 1892.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Food-borne hepatitis A in a general hospital. Epidemiologic study of an outbreak attributed to sandwiches
Authors: J. D. Meyers
Journal: JAMA (1975)

In November and December 1973, an outbreak of food-borne hepatitis A occurred in a busy general hospital. Epidemiologic investigation implicated cafeteria-made sandwiches. Eventually, 44 clinical and 22 subclinical cases of hepatitis were diagnosed among hospital employees. In addition, at least seven persons in the community became ill with hepatitis after eating in the hospital cafeteria; hospital patients were not, in general, affected. Two cafeteria workers were potentially implicated in the spread of hepatitis; both would have had subclinical hepatitis during the probable transmission period. It was recommended that food-handlers with icteric hepatitis remain out of work for at least two to three weeks after the onset of jaundice, while food-handlers with subclinical hepatitis remain out of work for at least two to three weeks after the peak of enzyme level elevation. (<i>JAMA</i>231:1049-1053, 1975)
Effects of Arsenic on Pyruvate Dehydrogenase Activation
Authors: Carol M. Schiller, Bruce A. Fowler, James S. Woods
Journal: Environmental Health Perspectives (1977)

Our studies illuminate a particular site of altered pyruvate utilization by liver mitochondria isolated from arsenic-fed rats. Initially, pyruvate dehydrogenase (PDH) levels were measured before and after in vitro activation. The liver homogenates were prepared from male rats given access to deionized drinking water solutions containing 0, 20, 40, and 85 ppm arsenic as sodium arsenate (As+5) for 3 and 6 weeks. After 3 weeks, the effects of arsenic at the highest dose level were pronounced on the basal activity (before activation), with inhibition up to 48% of the control values. The total PDH (after activation) was inhibited by 14, 15, and 28% of the control values at 20, 40, and 85 ppm As+5, respectively. A similar pattern of inhibition of PDH was observed at 6 weeks, although the inhibition was lower at the highest dose. This effect is probably a reflection of mitochondrial regeneration at this time and dose. The inhibition of PDH both before and after activation suggests a direct arsenic effect on pyruvate utilization which does not involve a lipoic acid moiety. Evidence is also presented which indicates an arsenic effect on the regulating kinase and/or phosphatase. The metabolic effects of impaired mitochondrial utilization by pyruvate are also discussed.
Correction
Authors: Stephanie Whelan, H Counihan, S Boland, N Falkiner, Drs Geoghegan, E De Valera, P Brennan
Journal: BMJ (1943)

Chemistry, Edinburgh University, on Saturday, June 5, at 2.30 p.m. Tea at 4.30 p.m.A one-day conference on casualty service has been arranged by the Citizens Guild for Civil Defence for Thursday, June 10, at Victory House, Leicester Square, W. The address of the Guild is 20, Buckingham Street
Abstract 5215: Targeting of HOX-PBX binding in glioblastoma multiforme as a novel therapeutic treatment
Authors: Richard Morgan, Monika Primon, Steven Shnyder, Susan Short, Balveen Kaur, Bangxing Hong, Izhar Bagwan, William Rogers, Hardev S. Pandha
Journal: Cancer Research (2019)

Abstract The HOX genes encode a family of transcription factors that play an essential role in embryonic patterning. They are also aberrantly expressed in numerous cancers, including glioblastoma (GBM). Three Amino Acid Loop Extension Homeobox (TALE) proteins act as important co-factors for HOX proteins, modulating their binding affinities to genomic targets. TALE proteins include the Pre-B-cell leukemia homeobox (PBX) proteins 1-4, which bind anterior HOX proteins, facilitating their nuclear entry and limiting their degradation. HTL00-1 is a 2nd generation hexapeptide drug that inhibits HOX-PBX dimer formation, and has been shown to induce rapid apoptosis in cancer cells, but not normal cells, through the rapid upregulation of genes including cFos, DUSP1, and EGR1. We have found that both HOX and TALE genes are markedly dysregulated in primary GBM tumors as well as in murine (GL261), adult (LN18, U87-MG, U251-MG) and pediatric (KNS42, SF188) GBM cell lines, all of which are sensitive to HTL-001. These genes were even more highly expressed in experimentally induced GBM cancer stem cells (CSCs) compared with parental lines, with a corresponding increase in sensitivity to HTL-001. We also investigated the in vivo activity of HTL-001 in Black 6 mice carrying GL-261 subcutaneous and orthotropic tumors with twice weekly intraperitoneal delivery. HTL-001 was shown to cross the blood brain barrier using Alexa660 labelled peptide, and significant anti-tumor activity was observed in both subcutaneous and orthotropic models with increased survival (p&amp;lt;0.02 and p&amp;lt;0.0078, respectively). Resected tumors from HTL-001 treated mice showed marked evidence of apoptosis, tumor vasculature disruption and focal necrosis compared to untreated tumors. Taken together, our findings indicate that HOX-PBX inhibition is a potential therapeutic target for adult and pediatric GBM patients. Citation Format: Richard Morgan, Monika Primon, Steven Shnyder, Susan Short, Balveen Kaur, Bangxing Hong, Izhar Bagwan, William Rogers, Hardev S. Pandha. Targeting of HOX-PBX binding in glioblastoma multiforme as a novel therapeutic treatment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5215.
More aggressive treatment urged for patients with prostate cancer
Authors: B. Bolsen
Journal: JAMA (1981)

Two thirds to three quarters of men with prostate cancer that has not yet metastasized receive only palliative treatment despite the fact that most, if not all, are candidates for either curative radiation therapy or surgery. That fact, turned up by the American College of Surgeons (ACS) in a nationwide survey of prostate cancer care in 1979, concerns both surgeons and therapeutic radiologists, who note that the disease afflicts 77,000 men and claims 22,000 lives annually. "We were surprised that there really isn't more aggressive therapy going on," said Robert L. Schmitz, MD, chairman of the Department of Surgery at Mercy Hospital, Chicago, and chairman of the ACS Commission on Cancer's Committee on Patient Care and Research. The committee collected data on 14,079 patients treated for prostate cancer at 658 hospitals in 1979 and on 20,166 patients treated at 419 hospitals in 1974. "Only 5% to 10% [of patients] get
Clinical Hematology
Authors: Leon O. Jacobson
Journal: JAMA (1962)

Since the first edition was published in 1942, it has undergone revision every 4 or 5 years. Unlike many volumes of similar proportions, the immense task of keeping pace with the rapid advance of knowledge in both basic and clinical areas falls solely to the original author and not to a panel of experts. To see the presentation as well done in this fifth edition as in the previous 4 is to understand what has made this book a classic in its field and has assured its evergrowing popularity. The organization of the book has not changed appreciably. The content, however, differs from that of the 1956 edition. Thus the section on the biochemistry of the erythrocyte has been greatly expanded, and the red cell enzymatic defect responsible for favism and primaquine sensitivity carefully detailed. The hemoglobinopathies are dealt with at molecular level, in keeping with the rapid growth of
AMA's "Medicine Today" TV program
Authors: L. Grouse
Journal: JAMA (1985)

The American Medical Association's (AMA) national television series for physicians, "Medicine Today," premiered on Jan 6, 1985. This broadcast was part of the launch of Lifetime Medical Television's "Doctors' Sunday," a mini-network providing a full day of programs for physicians each week on the Lifetime cable television network. "Medicine Today" is a half-hour program of medical news and commentary that can be seen each week as a part of "Physicians' Journal Update," a review of the medical literature. "Medicine Today" represents an important step by physicians in using the immediacy and power of television to advance the practice of medicine in this country. It provides rapid and personal communication between physicians; it establishes a collegial forum, devoted to issues and information that affect physicians; and it improves the dissemination of information about advances in medical research to the profession. The content of "Medicine Today" is derived from the journals, the
Wrong Dosage Equivalents
Journal: JAMA (1964)

breech in 4. Sixteen infants survived, and one fetus died with prolapsed cord before the mother's ad¬ mission to the hospital.Death was attributed to the presentation.The corrected fetal loss for this method is 6%.In eight cases, after successful ex¬ ternal version, a binder was used to hold two rolled towels in place-one each side by the ab¬ domen-thus keeping the fetus in the converted
Treatment of gonorrhea. Penicillin or tetracyclines?
Authors: H. H. Neumann
Journal: JAMA (1972)

Broad spectrum antibiotics, given orally, were compared with penicillin for treatment of uncomplicated gonorrhea in male patients at the New Haven Health Department VD Clinic. Treatment success appeared more favorable with doxycycline than with penicillin, although the differences between the two drugs were not statistically significant. In addition to the acceptable therapeutic results, several public health considerations suggest the broad spectrum antibiotics as the drugs of first choice in the routine care of uncomplicated gonorrhea. Penicillin appears too valuable a drug to be used injudiciously for a disease which is as widespread and as likely to recur as gonorrhea.
"ALEXITHYMIA: A RELEVANT PSYCHOLOGICAL VARIABLE IN NEAR-FATAL ASTHMA". J. SERRANO, V. PLAZA, B. SUREDA, J. DE PABLO, C. PICADO, S. BARDAGI, J. LAMELA AND J. SANCHIS, ON BEHALF OF THE SPANISH HIGH RISK ASTHMA RESEARCH GROUP. EUR RESPIR J 2006; 28: 296-302.
Journal: European Respiratory Journal (2009)
Exercise programs for the elderly. Council on Scientific Affairs
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vasectomy
Authors: Robert S. Gould
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In the EDITORIAL on Feb 28, 1972, Dr. Harold Lear stated that vasectomy results in severe impairment or loss of a major body function, suggested that the medical profession should not condone vasectomy "on demand," and suggested that even the "most optimistic surveys indicate a potential 3% psychosexual casualty rate." I have performed more than 600 vasectomies. I see my patients six weeks and six months after the procedure and every patient, without exception, has been delighted with the results. This seems to me to be significantly better than the "3% psychosexual" problems that Dr. Lear suggested is the best result available. For those of us who are performing hundreds of vasectomies every year, this EDITORIAL does not realize that vasectomy can provide a very real release from the overwhelming problem of unwanted pregnancy. As a physician actively involved in family planning, I am sure that the
Targeting Resistance in Lung Cancer
Journal: Cancer Discovery (2013)

Abstract Two investigational drugs, AstraZeneca's AZD9291 and Clovis Oncology's CO-1686, both showed encouraging results in early trials of patients with EGFR-mutated non–small cell lung cancer (NSCLC) who have developed resistance to targeted therapies. Pfizer's investigational agent PF-06463922, developed for patients with ALK-mutated NSCLC who have developed resistance to crizotinib, demonstrated strong activity and selectivity in preclinical research and will be studied in a phase I clinical trial launching by year-end.
Abortion---a hell of a decision
Authors: None Anonymous
Journal: BMJ (2000)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Abortion—a hell of a decision Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Hepatic scintillography.
Authors: E A Jones
Journal: Gut (1967)

Hepatic scintillographySince hepatic scintillography was first introduced in 1953,1 this technique has been extensively applied to the investigation of patients with liver diseases.After the intravenous injection of a gammaemitting isotope which is selectively taken up by the liver, the organ is scanned with a collimated scintil- lation probe, the output of which is converted into suitably selected electrical impulses, which are plotted either as dots on paper or by a photo recording device.2The various settings of the scanning equipment must be appropriately standardized before any meaningful comparison of different scans can be made.
Southern Hospitality
Authors: Kimberly D Manning
Journal: Annals of Internal Medicine (2010)

On Being a Doctor2 February 2010Southern HospitalityKimberly D. Manning, MDKimberly D. Manning, MDFrom Emory University School of Medicine, Atlanta, GA 30303.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-3-201002020-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “I thank the Lord every day that I lost my insurance,” Mrs. Coleman said with a raspy voice. “Without y'all, I know this all would have been different. I wouldn't change a thing.” She stared at me without blinking, an almost hypnotizing gaze that held me captive. I wanted to look away but couldn't. Instead, I sat in respectful silence.Mrs. Coleman was more than just a patient to me. She was the mother of one of my close friends from college. Our relationship wasn't built on prescription instructions or follow-up appointments. It was born on the many weekend road ... Author, Article, and Disclosure InformationAffiliations: From Emory University School of Medicine, Atlanta, GA 30303.Corresponding Author: Kimberly D. Manning, MD, Emory University School of Medicine, 49 Jesse Hill Jr. Drive SE, Atlanta, GA 30303; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 February 2010Volume 152, Issue 3Page: 190-191KeywordsEatingEmergency departmentPollenPrimary hypertensionResidencyShouldersSmellStomachThoraxWalking ePublished: 2 February 2010 Issue Published: 2 February 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Amphetamines and Malignant Lymphoma
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal