tbuckley/cabot-search huggingface dataset:
Nervous
Authors: Davey Smith
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Words (canopy)
Authors: D. G Grosset
Journal: BMJ (1988)

<h3>Objective</h3> Drowning is a major cause of unintentional childhood death. The relationship between childhood swimming pool submersions, neighbourhood sociodemographics, housing type and swimming pool location was examined in Harris County, Texas. <h3>Study design and setting</h3> Childhood pool submersion incidents were examined for spatial clustering using the Nearest Neighbor Hierarchical Cluster (Nnh) algorithm. To relate submersions to predictive factors, an Markov Chain Monte Carlo (MCMC) Poisson-Lognormal-Conditional Autoregressive (CAR) spatial regression model was tested at the census tract level. <h3>Results</h3> There were 260 submersions; 49 were fatal. Forty-two per cent occurred at single-family residences and 36% at multifamily residential buildings. The risk of a submersion was 2.7 times higher for a child at a multifamily than a single-family residence and 28 times more likely in a multifamily swimming pool than a single family pool. However, multifamily submersions were clustered because of the concentration of such buildings with pools. Spatial clustering did not occur in single-family residences. At the tract level, submersions in single-family and multifamily residences were best predicted by the number of pools by housing type and the number of children aged 0–17 by housing type. <h3>Conclusions</h3> Paediatric swimming pool submersions in multifamily buildings are spatially clustered. The likelihood of submersions is higher for children who live in multifamily buildings with pools than those who live in single-family homes with pools.
Is allergen immunotherapy effective in asthma? A meta-analysis of randomized clinical trials.
Authors: J Bousquet, F B Michel, H J Malling
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Is allergen immunotherapy effective in asthma? A meta-analysis of randomized clinical trials.." American journal of respiratory and critical care medicine, 152(5), pp. 1737–1738
Incorrect Information
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Sulfonamides
Authors: Louis Weinstein, Morton A. Madoff, Charles M. Samet
Journal: New England Journal of Medicine (1960)

Use of Sulfonamides in Combination with AntibioticsWhen penicillin and streptomycin first became available they were often given together with sulfonamides in cases in which, used alone, they failed to produce a prompt response. In some cases the use of such mixtures was based on in vitro observations suggesting an additive or even synergistic activity.215 216 217 In others, it was predicated on the unproved premise that a "broad-spectrum" effect could be achieved. As more potent antimicrobial agents have been developed, the administration of antibiotic-sulfonamide combinations has decreased. However, clinical experience suggests that these have better therapeutic results than either agent alone . . .
LETTER FROM NEW YORK.
Authors: None P. B. P.
Journal: JAMA (1889)

(FROM OUR OWN CORRESPONDENT.) Lobar Pneumonia; an Analysis of Fifty-six Fatal Cases— Classification of Pneumonia — Complications, Diagnosis and Treatment of Pneumonia. Dr. Satterthwaite, the well-known pathologist, has recently presented to the Academy of Medicine a new study of lobar pneumonia, which was principally based on an analysis of fifty-six fatal cases observed by him. The paper was one of those which do not by any means show for what they are worth, as the expression is, but which in reality involve an immense amount of hard and conscientious work; and it will no doubt constitute a real addition to the literature of a subject which must necessarily always be of the greatest practical interest to the profession. The classification which Dr. Satterthwaite makes of the principal types of pneumonia are as follows: 1. Acute lobar pneumonia; 2. secondary lobar pneumonia; 3. embolic lobular pneumonia; 4. bronchial lobular pneumonia; 5.
Corrections
Journal: Thorax (2008)

The Guideline Development Group regret that no advice was offered for the management of status epilepticus.As this is a life-threatening condition where a patient may suffer from cerebral hypoxia (and oximetry may not be possible), patients with status epilepticus should be treated in accordance with table 1 (reservoir mask until clinically stabilised).This advice also applies to other rare conditions that may cause life-threatening hypoxaemia that are not listed specifically in table 1.
Drug treatment of psychiatric patients in general practice.
Authors: P Naish
Journal: BMJ (1979)

above, and to refer to dialysis and trans- plantation treatment as "extraordinary" is surely an unjustifiable judgment.At a time when the referral rate to nephrologists clearly indicates that many patients are dying from end-stage renal failure without the benefit of proper assess- ment, the general medical profession should be clearly aware of the real benefits of renal replacement therapy.
This Week in &lt;EMPH TYPE="ITAL"&gt;JAMA&lt;/EMPH&gt;
Journal: JAMA (2003)

A Piece of My Mind"An eerie silence enveloped the trauma room, an event that frequently precedes a pediatric resuscitation."From "A Little Bit Longer." SEE PAGE 716 Contempo UpdatesImprovements in the care of serious burns. SEE PAGE 719 Medical News & PerspectivesA program that allows physicians to offer in-office treatment to opiateaddicted patients has been hailed as a way to "de-ghettoize" treating such individuals.But few physicians have embraced the opportunity. SEE PAGE 731 National Health InsuranceA proposal for a single-payer national health insurance program with universal, comprehensive coverage that would both expand access to care and reduce costs.
General practice vs. family practice
Authors: L. B. Blanchard
Journal: JAMA (1971)

The terms "general practice" and "family practice" continue to be used interchangeably, in spite of conceptual differences. One can only guess to what extent this semantic problem has impeded progress in the development of family practice. For many years, members of our medical school faculties have been telling their students that because of rapidly increasing medical knowledge and skills, no one physician can know and do it all well, and, therefore, general practice means poor practice. The "official" definitions of these two terms is given in the AMA Council on Medical Education's Willard Report: "Family practice refers to the function of the practitioner, while general practice refers to the content of his practice."<sup>1</sup>One may amplify these definitions: General practice refers to the depth of knowledge and skills a practitioner has developed in all the clinical disciplines, whereas family practice refers to the manner in which he applies his
Preoperative pulmonary function testing
Authors: A. J. Block
Journal: JAMA (1976)

PREOPERATIVE pulmonary function testing is easy to perform. Setups for spirometry are cheap and simple, and automated systems are available to compute all varieties of measurement. Today's problems for the clinician are "What does preoperative pulmonary function testing mean?" and "Who needs these studies?" The patient with bronchogenic carcinoma often has concomitant obstructive airway disease, since cigarette smoking is a common factor. If a surgeon contemplates resection of the carcinoma, pneumonectomy looms as a possibility. If the possibility of removing an entire lung exists, the assessment of pulmonary function is mandatory. Consequently, much has been written about preoperative assessment of the pneumonectomy candidate. <h3>Assessment for Pneumonectomy</h3> The understanding of preoperative assessment for pneumonectomy has proceeded in three phases. First to be recognized was that reduction of<i>total</i>function made removal of a lung hazardous.<sup>1-3</sup>The amount of reduction (and by what test) and the hazard of the operation were
INSIDIOUS PLEURISY.
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE SURGICAL TREATMENT OF RECTAL CANCER
Authors: J. P. L. Mummery
Journal: BMJ (1912)

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Traditionally, MS was held to be a T-cell mediated disease, but accumulating evidence during the last decade also highlighted the crucial importance of B cells for the disease progression. Particularly, B cell depleting therapies (BCDTs), have demonstrated striking efficacy in suppressing inflammatory disease activity in relapsing-remitting MS. However, a detailed understanding of the role of B cells in the pathogenesis of MS is still lacking, and by extension also the mechanism of action of BCDTs. In this longitudinal multi-center study, we investigated the impact of BCDTs on the immune landscape in MS patients using high-dimensional single-cell immunophenotyping (cytometry by time-of-flight; CyTOF). Algorithm-guided analyses revealed phenotypic changes in the newly reconstituted B cell compartment after BCDT, as well as a marked specific reduction of circulating T follicular helper (Tfh) cells with a concomitant upregulation of CD27 surface expression in memory T helper cells and Tfh cells. These findings indicate a costimulatory mechanism in the CD27/CD70 signaling pathway, through which B cells sustain the activation of pathogenic T cells. Disrupting the CD27/CD70 signaling axis via BCDTs provides a potential explanation for its clinical efficacy.
Omission
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The impact of Medicare's prospective payment system on Wisconsin nursing homes
Authors: M. A. Sager
Journal: JAMA (1987)

To assess the impact of Medicare's prospective payment system (PPS) on nursing homes, we reviewed hospitalization and mortality data for Wisconsin's Medicaid and general elderly populations. During the 12 months following implementation of the PPS, Wisconsin's institutionalized elderly Medicaid population experienced a 72% increase in the rate of hospitalization and a 26% decline in hospital length of stay. Two explanations for the increased hospitalization include physician manipulation of the PPS and increased rehospitalization of nursing home residents who may have been discharged prematurely from hospitals. Between 1982 and 1985, analysis of mortality data revealed a 26.2% increase in the rate of deaths occurring in nursing homes. The increase in nursing home deaths began in 1983 and was associated with a 10.3% decline in hospital deaths during the same period. Using a series of logistic analyses, the shift in location of death from hospitals to nursing homes was found to be more pronounced after implementation of the PPS. This change in location of death may reflect both a less aggressive use of hospital resources by physicians caring for terminally ill patients and a transfer of seriously ill patients to nursing homes for terminal care. (<i>JAMA</i>1987;257:1762-1766)
Chromosome analysis techniques expand; new links to cancer
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2954: In Vivo Molecular Imaging of Myocardial Angiogenesis Using <sup>99m</sup> Tc-RAFT-RGD, a Novel α <sub>v</sub> β <sub>3</sub> Integrin-Specific Tracer
Authors: Julien Dimastromatteo, Guillaume Pons, Laurent Riou, Eric Pellegrini, Tatiana Gavrilina, Mitra Ahmadi, Didier Boturyn, Pascal Dumy, Daniel Fagret, Catherine Ghezzi
Journal: Circulation (2007)

Introduction - Myocardial angiogenesis following reperfusion of an infarcted area affects postinfarct remodelling and may therefore impact on patient prognosis. The non-invasive molecular imaging of angiogenesis is thus of potential clinical relevance in this setting. Angiogenic vessels overexpress the α v β 3 integrin. Tc-RAFT-RGD is a novel 99m Tc-labelled tracer composed of four α v β 3 integrin-specific cyclo(RGDfK) sequences tethered on a cyclodecapeptide platform. Hypothesis - We hypothesized that Tc-RAFT-RGD binding to the α v β 3 integrin would allow the molecular imaging of myocardial angiogenesis in vivo. Methods - Myocardial infarction was induced by left anterior descending coronary artery occlusion for 45 min prior to reperfusion in 24 anesthetized male Wistar rats. Fourteen days later, the animals were injected intravenously with Tc-RAFT-RGD (n = 16) or Tc-RAFT-RAD (negative control, n = 8). Tracer uptake was assessed 60 min following injection in 12 and 4 animals injected with Tc-RAFT-RGD and Tc-RAFT-RAD, respectively. In those animals, the hearts were quickly excised for autoradiographic imaging, nitroblue tetrazolium (NBT) infarct staining, CD31 immunostaining of neovessels, and for gamma-well counting of myocardial tracer activity in the infarcted and normal areas. The remaining animals were dedicated to in vivo dual-isotope pinhole SPECT imaging following the simultaneous injection of Tl-201 and Tc-RAFT-RGD (n = 4) or Tc-RAFT-RAD (n = 4). Results - Neovessels were observed in the infarcted area using CD31 immunostaining. The Tc-RAFT-RGD infarcted-to-normal zone activity ratios by gamma-well counting and ex vivo imaging (2.6 ± 0.6 and 3.9 ± 1.0, respectively) were significantly higher than those of Tc-RAFT-RAD (1.7 ± 0.5 and 2.1 ± 0.4, respectively, P&lt; 0.05). Quantification of short-axis images from SPECT acquisitions indicated similar Tl-201 defect magnitudes in animals injected with Tc-RAFT-RGD and Tc-RAFT-RAD (0.3 ± 0.1 and 0.4 ± 0.1, P =NS). The infarcted area was readily visible in vivo with Tc-RAFT-RGD but not with Tc-RAFT-RAD (infarct-to-normal zone activity ratio, 2.8 ± 0.6 and 1.6 ± 0.4, respectively, P&lt; 0.05). Conclusions - Tc-RAFT-RGD allowed the experimental in vivo molecular imaging of myocardial angiogenesis.
Application of clinical indicators in the emergency department
Authors: M. R. O'Leary
Journal: JAMA (1989)

Clinical indicators were developed and used to assess the quality of patient care resulting from the system of shared responsibility between emergency department (ED) and radiology department faculty physicians for interpretation of ED roentgenograms. The first indicator—all discrepancies in roentgenogram interpretation between ED and radiology department faculty—measured an overall discrepancy rate of 3.3% (776 films). Three hundred fifty-two apparent discrepancies were not related to the accuracy with which ED faculty interpreted films, resulting in a revised overall discrepancy rate of 1.8%. The second indicator— undesirable patient care outcomes as a result of delayed accurate radiological diagnosis—measured an occurrence rate of 0 after clinical reevaluation of more than 99% of patients within 24 hours of initial ED evaluation. Aspects of the development and use of clinical indicators are discussed in relationship to the broader monitoring and evaluating process necessary for the continuous improvement of patient care. (<i>JAMA</i>. 1989;262:3444-3447)
Atypical fibroxanthoma
Authors: R. Stadler
Journal: Journal of Clinical Oncology (2007)

20522 We report on 15 patients who were diagnosed and treated with atypical fibroxanthoma in the Department of Dermatology Minden since 1994. The patients were between 35 and 85 years old with a mean age of 69.9 years. Of the 13 males and 2 females solitary tumours were observed at the ear in 5 patients, at the capillitium in 5 patients, in the face in 3 patients and in the shoulder/axilla area in 2 patients. The lesion were 0.5 to 15 mm in size and half of them ulcerated in severely damaged actinic skin. Histologically, the tumours showed pleomorphic histiocyte proliferation and atypical giant cells often with bizarre nuclei and numerous mitotic figures. Immunohistologically, the tumours were vimentin positive and HMB45, S100, keratin, desmin, EMA, CD34, and actin negative. The clinical evaluation showed no metastatic lesions. The tumours were treated by radical surgery and followed up every half year. The mean observation time is now 24 months without any recurrence. The atypical fibroxanthoma was first reported in 1963 by Helwig. Nowadays, it is thought to be a low grade malignancy as the superficial variant of malignant fibrous histiocytoma. Important is that this tumour follows an indolent behaviour but locally an aggressive course. Small numbers of metastases have been reported. The differential diagnoses includes dermatofibrosarcoma protuberans, malignant melanoma, spindle-cell squamous cell carcinoma and other rare tumour entities The clinical picture should be known not to underestimate this fibrous histiocytic neoplasm as a benign lesion. No significant financial relationships to disclose.
Availability of Computerized Health Information Database From the World Health Organization, European Region (WHO-Europe)
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal