tbuckley/cabot-search huggingface dataset:
Effects of extracellular matrices on tube formation of cultured rat hepatic sinusoidal endothelial cells
Authors: S SHAKADO
Journal: Hepatology (1995)

To determine the effects of extracellular matrices on the function and morphology of hepatic sinusoidal endothelial cells, isolated rat hepatic sinusoidal endothelial cells were cultured in three-dimensional fashion on collagen gel containing various extracellular matrix components. Cells cultured on type I collagen gel with or without type IV collagen formed a cobblestone appearance on the surface of the gel. Cells cultured on laminincontaining type I collagen gel invaded the gel and exhibited three-dimensional tube formation with a decreased number of characteristic endothelial pores. Morphometrically, there was a significant relationship between the length of the tube formed and the concentration of laminin in the type I collagen gel. Cells cultured on Matrigel, which contains high concentrations of laminin, type IV collagen, fibroblast growth factor, tissue plasminogen activator, and other growth factors, formed a great number of tubes into a network on the surface of the gel, as is observed in in situ hepatic sinusoidal endothelial cells. Ultrastructurally, tube-forming endothelial cells cultured on Matrigel had many endothelial pores on the cell surface, with tubes (approximately 10 μm in diameter) formed by two or three hepatic sinusoidal endothelial cells. These results indicated that extracellular matrix components, especially laminin, induced the formation of tubes in cultured rat hepatic sinusoidal endothelial cells. Tube-forming sinusoidal endothelial cells cultured on Matrigel could provide more advantages than the two-dimensional culture model for investigating the function and morphology of these cells in vitro. (Hepatology 1995; 22:969–973.)
Segmental neurofibromatosis
Authors: A.P. ORANJE, V.D. VUZEVSKI, T.J. KALIS, W.F.M. ARTS, TH. JOOST, E. STOLZ
Journal: British Journal of Dermatology (1985)

A child with segmental neurofibromatosis is reported. The clinical, histopathological and ultrastructural characteristics of this rare condition are described. This entity is considered to be a localized form of von Recklinghausen's disease. The aetiology is not clear, but somatic mutation in early embryonic development may be important.
Diseases of the Digestive Organs with Special Reference to Their Diagnosis and Treatment.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INCREASED AMOUNT OF URIC ACID IN THE BLOOD IN THE TOXEMIAS OF PREGNANCY
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular complications of imipramine intoxication
Authors: M. H. Sacks
Journal: JAMA (1968)

A 2 1/2-year-old boy died as a result of cardiovascular complications of imipramine hydrochloride overdosage. Through a direct toxic effect on the myocardium, imipramine lowers myocardial contractility and cardiac output with resultant hypotension. Cardiac arrhythmias are also a constant feature of imipramine toxicity. Since there is no specific antidote to imipramine, treatment of over-dosage with this drug must be directed at its life-threatening circulatory and respiratory manifestations if the patient is to stand any chance for survival.
Serum Polychlorinated Dibenzo-p-Dioxins and Polychlorinated Dibenzofurans among People Eating Contaminated Home-Produced Eggs and Beef
Authors: Lynn R. Goldman, Martha Harnly, Jennifer Flattery, Donald G. Patterson, Larry L. Needham
Journal: Environmental Health Perspectives (2000)

We compared serum polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) among residents of two homes to levels among age- and sex-matched comparison subjects. The residents of the two homes consumed contaminated eggs and beef from animals raised at the homes. The animals had greater soil contact than those raised with conventional commercial husbandry practices. The comparison subjects were from a similar rural area, but did not consume home-produced beef and eggs. Serum levels of 2,3,7, 8-substituted tetra-, penta-, and hexaCDDs and penta-, hexa-, and heptaCDFs were increased between 2- and 6-fold in residents from one home; contaminated eggs and beef were consumed by residents for 2-15 years. Elevations were less for those in the other index home, where only home-produced eggs were consumed for 2 years; a 3-fold elevation of 1,2,3,7,8,9-hexaCDD as compared to controls was most apparent. Very strong bivariate correlations among all of the 2,3,7, 8 penta- and hexaCDDs/CDFs were observed. The elevations observed verify that PCDD/PCDF-contaminated food contributed to the body burden of these compounds. The blood levels among the highest exposed participants are generally higher than those observed in other studies of U.S. contaminated-fish consumers and higher than average adipose tissue levels observed in U.S. urban populations. There are sufficient animal toxicologic and human epidemiologic data to recommend that exposures be reduced. In the study area, pentachlorophenol and pentachlorophenol incineration sources have been identified, and the animal contamination and blood elevations probably reflect these sources. Soil reference values and site-specific risk assessments should include estimates of exposures to contamination in home-produced animal products. Such estimates can be verified with limited PCDD/PCDF sampling of animals and humans.
Film Reviews
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The International Medical Annual and Practitioners' Index.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trans-Fatty Acids and Their Effects on Lipoproteins in Humans
Authors: M. B. Katan
Journal: Annual Review of Nutrition (1995)

Trans fatty acids raise plasma low-density lipoprotein (LDL) cholesterol levels in volunteers when exchanged for cis unsaturated fatty acids in the diet. In addition, trans fatty acids may lower high-density lipoprotein (HDL) cholesterol levels and raise triglyceride and lipoprotein(a) levels in plasma. Trans and cis unsaturated fatty acids are thus not equivalent, and diets aimed at reducing the risk of coronary heart disease should be low in both trans and saturated fatty acids.
Homeopathy
Authors: James C. Mohr
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome after allogeneic bone marrow transplant for leukemia in older adults
Authors: O. Ringden
Journal: JAMA (1993)

<h3>Objective.</h3> —To determine whether age over 40 years is associated with adverse outcome after allogeneic bone marrow transplantation for leukemia. <h3>Design.</h3> —A retrospective analysis of outcome after bone marrow transplants for leukemia reported to the International Bone Marrow Transplant Registry (IBMTR) among recipients 30 through 39 years, 40 through 44 years, 45 through 49 years, and 50 years of age and older. <h3>Setting.</h3> —Transplantations performed in 138 institutions worldwide and reported to the IBMTR. <h3>Patients.</h3> —A total of 2180 recipients of HLA-identical sibling bone marrow transplants for leukemia, divided into four cohorts based on age: 30 through 39 years (n=1282), 40 through 44 years (n=527), 45 through 49 years (n=291), and 50 years and older (n=80). <h3>Main Outcome Measures and Results.</h3> —Incidence of leukemia-free survival, graft-vs-host disease, and relapse was comparable among the four age cohorts. Patients with advanced leukemia aged 45 years or older had a slightly higher risk of treatment-related mortality, and the 45- through 49-year-old cohort had a higher risk of interstitial pneumonia. <h3>Conclusions.</h3> —These data indicate that among leukemia patients over 30 years of age at the time of allogeneic bone marrow transplantation, increasing age into the fifth decade does not adversely affect outcome after transplants from HLA-identical siblings. (<i>JAMA</i>. 1993;270:57-60)
Protecting Health Workers From Zika During Labor and Delivery
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BMA warns against unnecessary screening tests in private sector
Journal: BMJ (2005)

make precise conclusions about the size of the effect, though the consistency of the associations we observed between both infant size and growth and later obesity across a range of settings and time periods suggest that the association is robust.As this review was part of a much larger review it was impractical to obtain original data from study authors to carry out secondary analyses. ConclusionsInfants in the highest end of the distribution for weight or body mass index and those who grow rapidly are at increased risk of obesity in childhood and adulthood.This suggests that factors during infancy or before that are related to infant growth influence the risk of later obesity.The relation of infant growth with other health outcomes should be explored to assess whether interventions to alter infant growth to prevent obesity are likely to be associated with other benefits or harms.It will also be important to assess whether factors influencing infant growth are amenable to change, to establish which strategies might alter infant growth, and to find out whether these are acceptable to parents.
Ampicillin Nephropathy
Authors: Douglas Maxwell
Journal: JAMA (1974)

INTERSTITIAL nephritis has been reported as a complication of a variety of chemically unrelated drugs. Phenindione<sup>1</sup>was the first agent reported to produce interstitial nephritis and acute renal failure. However, phenacetin and associated analgesic compounds comprise the majority of the etiological agents.<sup>2</sup>While penicillin and methicillin sodium<sup>3</sup>have also been incriminated in this disease, there are few reports of ampicillin-induced interstitial nephritis. This article describes a woman who developed this complication of ampicillin sodium therapy. Conservative management led to complete recovery of renal function. <h3>Report of a Case</h3> A 43-year-old woman was admitted to the psychiatry service with a diagnosis of paranoid schizophrenia. She had been hospitalized six times previously for her psychosis. She gave no history of genitourinary disease or known allergies. Therapy was started with chlorpromazine, 600 mg daily. On the 18th hospital day, she complained of a sore throat, and her temperature was 40 C
Commentaire de travail de O. Pech et al., pp. 456
Journal: Endoscopy (2010)

See also: Accuracy of endoscopic ultrasound in preoperative staging of esophageal cancer: results from a referral center for early esophageal cancerEndoscopy 2010; 42(06): 456-461DOI: 10.1055/s-0029-1244022
BILIARY STASIS
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 208: Follow-up Study in Kawasaki Disease By Treadmill Exercise Test And Echocardiography
Authors: Sin-Ae Park, Kichul Park, Jee Won Park
Journal: Circulation (2015)

Kawasaki disease (KD) may result in coronary aneurysm formation and increased risk of cardiovascular complications such as ischemic heart disease. Therefore, the early detection, non-invasive monitoring and long-term follow-up of myocardial ischemia are essential. This study sought to determine the ischemic heart disease by treadmill exercise test and two-dimensional echocardiography. Three hundred and four patients with a history of KD from 1995 to 2005 were retrospectively analyzed. Among them fifty patients who agree with the study underwent exercise test and 2D-echocardiography. The patients were followed for 11.6 years(8 to 17) from disease onset. The coronary artery ectasia regressed in 21 patients. No stenotic lesion could be found in the coronary artery in follow-up echocardiography. And no significant ischemic changes were detected. There is no evidence of persisting coronary ectasia and dysfunction of cardiac perfusion in patients with previous KD in this study. However, these patients should be counselled to avoid potential risk factors for other complication such as atherosclerosis and long term follow up is needed into adult life.
Differential expression of cyclooxygenase 2 in human colorectal cancer Reply
Authors: M HULL
Journal: Gut (2000)

DiVerential expression of cyclooxygenase 2 in human colorectal cancerEDITOR,-We were puzzled by the recent paper by Dimberg and colleagues (Gut 1999;45:730-732) which reported that upregulation of cyclooxygenase 2 (COX-2) protein expression was prominent in rectal adenocarcinomas compared with that in adenocarcinomas arising from the colon."Low or undetectable levels of COX-2 protein expression" were demonstrated in 15 of 19 colonic adenocarcinomas located proximal to the rectum.Overall, upregulation of COX-2 protein expression was reported in only 56% of colorectal cancers.Previous reports, 1-7 which include one by the current authors on a not dissimilar case series, 1 and two in the joint authorship of the accompanying commentary writer, 2 3 have shown consistent upregulation of COX-2 expression in colonic and rectal adenocarcinomas (in 85-90% of cases) compared with matched normal colonic mucosa using diVerent techniques, including northern blot analysis, RT-PCR, western blot analysis, and immunohistochemistry. Furthermore, four of these studies refer to the distribution of adenocarcinomas throughout the colon without showing evidence of diVerential COX-2 expression between rectal and more proximal tumours. 1 2 4 5 In the one previous study which analysed COX-2 protein expression in human colorectal cancers by western blot analysis, 7 immunoreactive COX-2 was detected in 76% of cases with a 10-fold increase in median tissue COX-2 concentration compared with normal colonic mucosa.In our view, the authors should attempt to explain the discrepancy between their results and previously published data.It is interesting to note that, in the study of Kargman et al, five of six patients taking NSAIDs had low or undetectable COX-2 protein expression. 7Moreover, aspirin has recently been shown to suppress induction of COX-2 mRNA and protein in interleukin-1 and phorbol ester stimulated human endothelial cells and fibroblasts. 8Do the authors have data on NSAID use in their cohort of patients prior to surgery?
Serum and intrahepatic HBV markers and HBV-specific CD8 T cell responses after nucleos(t)ide analog therapy discontinuation in HBeAg-negative chronic hepatitis B patients
Authors: Mireia García-López, Sabela Lens, Laura J. Pallett, Barbara Testoni, Zoe Mariño, Sergio Rodriguez-Tajes, Concepció Bartres, Ester García-Pras, Thais Leonel, Elena Perpiñan, Juanjo Lozano, Francisco Rodríguez-Frías, George Koutsoudakis, Fabien Zoulim, Mala Maini, Xavier Forns, Sofía Pérez-del-Pulgar
Journal: Journal of Hepatology (2020)