tbuckley/cabot-search huggingface dataset:
Long-Term Health Effects of Particulate and Other Ambient Air Pollution: Research Can Progress Faster If We Want It to
Authors: Nino Kunzli, Ira Bruce Tager
Journal: Environmental Health Perspectives (2000)

There is need for the assessment of long-term effects of outdoor air pollution. In fact, a considerable part of the large amount of U.S. research money that has been dedicated to investigate effects of ambient particulate pollution should be invested to address long-term effects. Studies that follow the health status of large numbers of subjects across long periods of time (i.e., cohort studies) should be considered the key research approach to address these questions. However, these studies are time consuming and expensive. We propose efficient strategies to address these questions in less time. Apart from long-term continuation of the few ongoing air pollution cohort studies in the United States, data from large cohorts that were established decades ago may be efficiently used to assess cardiorespiratory effects and to target research on detection of the most susceptible subgroups in the population, which may be related to genetic, molecular, behavioral, societal, and/or environmental factors. This approach will be efficient only if the available air pollution monitoring data will be used to spatially model long-term outdoor pollution concentrations across a given country for each year with available pollution data. Such concentration maps will allow researchers to impute outdoor air pollution levels at any residential location, independent of the location of monitors. Exposure imputation may be based on residential location(s) of participants in long-standing cardiorespiratory cohort studies, which can be matched to pollutant levels using geographic information systems. As shown in European impact assessment studies, such maps may be derived relatively quickly.
Non-Parenchymal Cell Biology
Authors: Qin Ning, Tao Chen, Lin Zhu, Ling Ding, Li Song, Xiaoping Zhang, Aichao Shi, Xiaoping Luo, Alexander Hodge, Dinushka Lourensz, Jorge Tchongue, George Yeoh, Rebecca Lim, William Sievert, Victoria Gadd, Richard Skoien, Kevin Fagan, Katharine Irvine, Elizabeth Powell, Andrew Clouston
Journal: Hepatology (2013)

murine hepatitis virus strain 3 (MHV-3) induced fulminant viral hepatitis (MHV-3-FVH) mice model was adopted in the study.The mouse KCTD9 (mKCTD9) expression plasmid and an shRNA plasmid specifically targeting this molecule were constructed and introduced into infected mice by hydrodynamic delivery.The expression of KCTD9 as well as function of hepatic NK cells was detected, respectively.Results: The results showed abundant expression of KCTD9 in hepatic NK cells from mice with MHV-3 infection.The shRNA significantly inhibited KCTD9 expression in hepatic NK cells with decreased CD69 expression, cytotoxicity and ameliorated MHV-3-FVH in these mice demonstrating as an increased survival, improved liver functions and histopathology manifestation.In contrast, delivery of the KCTD9 expression plasmid to MHV-3-infected mice led to a profound progression of liver disease.Conclusion: Our study further elaborated the novel KCTD9 gene contributes to liver injury through NK cell activation in virus-induced liver failure, while interference targeting KCTD9 gene could ameliorated the disease, which provide a potential therapeutic target for virus induced liver failure.
Oesophageal reflux and its myths.
Journal: BMJ (1979)

adrenaline, or MA plus NMA are due to a chemical rather than to a metabolic effect of labetalol and represent falsely high values.Adequate methods should be employed in future studies evaluating the effects of labetalol on the sympathetic nervous system.Further- more, our findings may prevent errors in the differential diagnosis of phaeochromocytoma.
Pigmented Nevi
Authors: E. J. Van Scott
Journal: JAMA (1963)

<h3>To the Editor:</h3> —The excellent report of a meticulous study by Dr. Allyn et al (p. 890 this issue ofThe Journal) represents the sixth in the past decade that has been concerned with the prevalence of palmar and plantar pigmented nevi. Relatively minor discrepancies exist among these reports. For instance, Dr. Allyn and co-workers find that plantar nevi are concentrated on the arch region. Knowing this in advance, I recently reviewed the raw data of our study reported several years ago and found that 43% of the plantar nevi recorded were on the arch. The drawings of Dr. Allyn show 70% on the arch. Perhaps this difference relates to where lines separating the arch from the rest of the plantar surface were drawn in each study; or perhaps a much larger series of subjects is necessary to determine true local distribution. Despite minor differences among reports, the conclusion of
258P First-line chemotherapies with FOLFIRINOX or gemcitabine plus nab-paclitaxel for unresectable pancreatic ductal adenocarcinoma in Japanese daily clinical practice
Authors: M. Yano, T. Terashima, T. Yamashita, M. Miyazawa, H. Mizuno, Y. Nomura, H. Omura, Y. Takata, N. Ooishi, H. Shugo, K. Yamada, H. Takabatake, H. Takatori, Y. Hodo, R. Nishino, T. Hayashi, E. Mizukoshi, S. Kaneko
Journal: Annals of Oncology (2016)
Reply to Stephen B. Williams, Donald L. Lamm, Ashish M. Kamat's Letter to the Editor re: Richard J. Sylvester, Willem Oosterlinck, Sten Holmang, et al. Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa–pT1 Urothelial Carcinoma of the Bladder: Which Patients Benefit from the Instillation? Eur Urol. In press. http://dx…
Authors: Richard Sylvester
Journal: European Urology (2015)
Organochlorine Pesticide Residues in Human Fat in the United Kingdom 1969-71
Authors: D. C. Abbott, G. B. Collins, R. Goulding
Journal: BMJ (1972)

During the period 1969-71 samples of human body fat were taken during routine necropsies on 201 subjects over 5 years old and 20 stillborn babies and infants under 5 years old, and analysis was carried out for organochlorine pesticide residues. By comparing the results from this period with those from similar studies undertaken in 1963-4 and 1965-7, it is clear that a downward trend continues.
Tobacco Taxes Won't Pay for Reform
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NATIONAL ASSOCIATION FOR THE PREVENTION OF CONSUMPTION
Journal: British Journal of Dermatology (1912)

British Journal of DermatologyVolume 24, Issue 1 p. 33-33 NATIONAL ASSOCIATION FOR THE PREVENTION OF CONSUMPTION First published: January 1912 https://doi.org/10.1111/j.1365-2133.1912.tb16694.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume24, Issue1January 1912Pages 33-33 RelatedInformation
Immunization Against Influenza
Authors: Robert H. Waldman
Journal: JAMA (1969)

During the A2 influenza epidemic of the winter of 1967 to 1968, commercially available inactivated influenza virus vaccine, bivalent, was administered by aerosol to 386 volunteers to test its efficacy in protecting against influenza illness. The illness rate in volunteers receiving the aerosolized vaccine was compared to that of 269 persons receiving the same vaccine subcutaneously and to that of 1,490 persons who received either sodium chloride solution or no inoculation. The group receiving aerosolized influenza vaccine had 79% fewer illnesses while subcutaneously immunized volunteers had 27% fewer illnesses, when compared to the control groups receiving no immunization. In addition to its superiority in ability to protect against naturally occurring influenza illness, the aerosolized vaccine led to a significantly lower incidence of side effects and to a significantly shorter duration of illness in those few who became ill.
Comparison of Perilymphatic and Cerebrospinal Fluid Pressures
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incorrect Number of Patients in Figure 3
Authors: Sanjay Desai, Leonard Feldman, Joseph Cofrancesco
Journal: JAMA Internal Medicine (2013)

ever, increasingly robust platforms will likely be needed.We further believe that the science of transitions of care will need to inform this ubiquitous process.The amount of data available for each patient can be easily overwhelming.There is a need to understand how to present and communicate effectively amidst that volume of information.Centers focused on patient safety are using human factors experts to examine the effective transfer of information.The results of this and other work can hopefully begin to establish best practices for handoffs and transitions of care.Ultimately, research in all these areas will inform an evidence-based approach to build the "new normal" for training the next generation of physicians.
AMERICAN JOURNAL OF ANATOMY.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hygiene of the Voice, with Twenty-seven Illustrations.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 89: The Prognostic Factor of Patients with Asystole on Arrival
Authors: Tomoki Shokawa, Koich Tanigawa, Hideya Yamamoto
Journal: Circulation (2007)

Background: Patients with asystole on arrival (AOA) at hospital have a poor prognosis. However, little is known about the prognostic factor of patients with AOA. Objective: The purpose of this study was to determine predictors for 24 hours survival in patients with AOA. Methods and results: Consecutive patients with AOA admitted to the Hiroshima University Hospital (Hiroshima, Japan) from April 2002 to January 2007 were retrospectively analyzed. Patients were divided into two groups according to the outcomes, i.e. non-survivors vs. survivors at 24 hours after admission. Data including blood gas analysis, lactate levels, and levels of minerals on admission were obtained and analyzed. Of 102 (male; 60) patients with AOA, fourteen patients survived for 24 hours. Univariate analysis found that pH, PaO2, PaCO2, base excess, lactate, and serum potassium concentration were associated with survival (p&lt; 0.05) (Table ). Multivariate analysis determined that serum potassium concentration independently affected 24 hours survival. Conclusions: These results suggested that the serum potassium level on admission is a strong, independent predictor of survival of patients with AOA. survivors vs. non-survivors
Economic Activity and Congenital Anomalies: An Ecologic Study in Argentina
Authors: Eduardo E. Castilla, Hebe Campana, Jorge S. Lopez Camelo, None The ECLAMC ECOTERAT Group
Journal: Environmental Health Perspectives (2000)

In this study, we analyze the association between industrial activity and the occurrence of 34 congenital anomalies. We selected 21 counties in Argentina during 1982-1994 and examined a total of 614,796 births in these counties in consecutive series. We used the International Standard Industrial Classification of All Economic Activities (United Nations, 1968) as an indicator of exposure to 80 specific industrial activities. Incidence rate ratios for each congenital anomaly were adjusted by the socioeconomic level of the county according to a census index of social deprivation. For a given exposure/anomaly association to be considered as significant and relevant, the exposure had to be a statistically significant risk for the occurrence of the anomaly and an increase in the birth prevalence rate of the congenital anomaly type involved had to be observed in those counties where the putative causal activity was being performed. Significant associations (p < 0.01) were identified between textile industry and anencephaly, and between the manufacture of engines and turbines and microcephaly. These observations are consistent with previous reports on occupational exposure, and their further investigation by means of case-control studies is recommended.
THE EXCRETORY CAPACITY OF THE NORMAL KIDNEY
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicinal Research Reviews
Journal: Medicinal Research Reviews (2006)

Graphical Abstract This review systematically summarizes the recent advances in AMPs development with respect to characteristics, structure-activity relationships, functions, antimicrobial mechanisms, expression regulation, and applications in food, medicine, and animals. The developments of peptidomimetics and AMPs/peptidomimetics-antibiotics hybrids as the next generation of antimicrobial agents are also introduced. The broad-spectrum antimicrobial activity and nonspecific physical membrane disruption mechanism of AMPs highlight their potential to be developed as potential alternatives to antibiotics.
4. Lifestyle Management:<i>Standards of Medical Care in Diabetes—2018</i>
Journal: Diabetes Care (2017)

The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.
EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the standing committee for international clinical studies including therapeutics (ESCISIT)
Authors: W Zhang
Journal: Annals of the Rheumatic Diseases (2006)

To develop evidence based recommendations for the diagnosis of gout.The multidisciplinary guideline development group comprised 19 rheumatologists and one evidence based medicine expert, representing 13 European countries. Ten key propositions regarding diagnosis were generated using a Delphi consensus approach. Research evidence was searched systematically for each proposition. Wherever possible the sensitivity, specificity, likelihood ratio (LR), and incremental cost-effectiveness ratio were calculated for diagnostic tests. Relative risk and odds ratios were estimated for risk factors and co-morbidities associated with gout. The quality of evidence was categorised according to the evidence hierarchy. The strength of recommendation (SOR) was assessed using the EULAR visual analogue and ordinal scales.10 key propositions were generated though three Delphi rounds including diagnostic topics in clinical manifestations, urate crystal identification, biochemical tests, radiographs, and risk factors/co-morbidities. Urate crystal identification varies according to symptoms and observer skill but is very likely to be positive in symptomatic gout (LR = 567 (95% confidence interval (CI), 35.5 to 9053)). Classic podagra and presence of tophi have the highest clinical diagnostic value for gout (LR = 30.64 (95% CI, 20.51 to 45.77), and LR = 39.95 (21.06 to 75.79), respectively). Hyperuricaemia is a major risk factor for gout and may be a useful diagnostic marker when defined by the normal range of the local population (LR = 9.74 (7.45 to 12.72)), although some gouty patients may have normal serum uric acid concentrations at the time of investigation. Radiographs have little role in diagnosis, though in late or severe gout radiographic changes of asymmetrical swelling (LR = 4.13 (2.97 to 5.74)) and subcortical cysts without erosion (LR = 6.39 (3.00 to 13.57)) may be useful to differentiate chronic gout from other joint conditions. In addition, risk factors (sex, diuretics, purine-rich foods, alcohol, lead) and co-morbidities (cardiovascular diseases, hypertension, diabetes, obesity, and chronic renal failure) are associated with gout. SOR for each proposition varied according to both the research evidence and expert opinion.10 key recommendations for diagnosis of gout were developed using a combination of research based evidence and expert consensus. The evidence for diagnostic tests, risk factors, and co-morbidities was evaluated and the strength of recommendation was provided.
Hazards of prolonged use of beclomethasone spray
Authors: T. J. H. Clark
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I was interested to read the answer given by Dr Irwin Polk to a question concerning the hazards of long-term use of inhaled beclomethasone, which appeared inThe Journal. This inhaled steroid has been used in the United Kingdom since 1972 and is available for prescription in more than 100 countries throughout the world. Its sales during the past decade suggest that more than 4 million patient-years of experience has been gained with this drug and, indeed, more than 500 clinical trials have been reported. The safety of inhaled beclomethasone has been well established by worldwide experience, and I know of no reports of clinically important systemic side effects from its treatment. It is true that with sensitive tests some systemic activity can be observed during therapy,<sup>1</sup>but most studies have shown that plasma cortisol levels and response to adrenal stimulation remains intact unless the dose of