tbuckley/cabot-search huggingface dataset:
Proceedings of the Tenth International Congress, 1952.
Journal: British Journal of Dermatology (1958)

British Journal of DermatologyVolume 70, Issue 3 p. 112-112 Proceedings of the Tenth International Congress, 1952. First published: March 1958 https://doi.org/10.1111/j.1365-2133.1958.tb13302.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume70, Issue3March 1958Pages 112-112 RelatedInformation
The Cover
Authors: Jacquelyn A. Lewis-Harris
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On Burns
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary vascular talc granulomatosis
Authors: I. S. Schwartz
Journal: JAMA (1986)

A 37-year-old physician who had multiple intestinal resections for complications of Crohn's disease developed disseminated malignant melanoma following excision of a primary cutaneous melanoma. He required long-term parenteral nutrition via a subclavian catheter because of the Crohn's disease and a surgically shortened bowel with multiple fistulas. Metastatic melanoma and episodes of partial intestinal obstruction caused recurrent pain, necessitating analgesic medication. The patient was known to self-administer pulverized meperidine hydrochloride (Demerol) tablets in suspension via his indwelling venous catheter over a period of several months prior to his death. At autopsy extensive deposits of metastatic melanoma were found in the gastrointestinal tract, heart, lungs, liver, and lymph nodes. The lungs demonstrated acute pulmonary edema. Microscopy showed widespread intravascular and perivascular foreign-body granulomas involving small pulmonary arterioles. These were composed of multinucleated giant cells and histiocytes with variable fibrosis, incorporating numerous yellowish refractile crystals having an elongated, needlelike, or rhomboidal shape. The
PLoS Medicine Issue Image | Vol. 6(7) July 2009
Journal: PLoS Medicine (2009)

The image this month relates to the Editorial and a paper by Doris Schopper and colleagues. The Editorial discusses the problems that can arise when research is done in the context of humanitarian relief work and notes that ethical oversight of such research needs to be rigorous, but also pragmatic. It discusses particularly the role of journals when papers arising from such research are submitted for publication. The article by Schopper and colleagues describes the functioning of the Médecins Sans Frontières independent ethics review board and the framework used for ethics review by this board, and discusses challenging ethical issues encountered by the board since its inception. Image Credit: mknobil at flickr.com
Error in Figure
Authors: Timothy Henry, Scott Sharkey, C Noel, Bairey Merz, Edyth Lindner, Michelle Lee, Clarence Gill, Enrique Garcia-Sayan
Journal: JAMA Cardiology (2019)

Sameed Ahmed M. Khatana, MD; Anjali Bhatla, BA; Ashwin S. Nathan, MD; Jay Giri, MD, MPH; Changyu Shen, PhD; Dhruv S. Kazi, MD, MS; Robert W. Yeh, MD, MSc; Peter W. Groeneveld, MD, MS
APARTMENT DISINFECTION.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 284: Combination therapies to prevent resistance to androgen deprivation therapies in prostate cancer
Authors: Zhenghong Li, Carrie Qi Sun, Rebecca Arnold, John A. Petros, Carlos S. Moreno
Journal: Cancer Research (2019)

Abstract Androgen receptor (AR) signaling is a distinctive feature of prostate cancer (PCa) and represents a major therapeutic target for treating metastatic prostate cancer (mPCa). Thus, androgen deprivation therapy (ADT) is a first-line treatment for mPCa. Although initially highly effective as a treatment for mPC, ADT is characterized by the frequent emergence of resistance, a disease state termed castration-resistant prostate cancer (CRPC) and is generally incurable after progression to metastatic disease. Therefore, understanding the mechanisms underlying CRPC and subsequent progression to metastatic disease is critical. In our previous study, which was mainly focused on how transcriptional networks change in response to ADT and lead to metastasis, we analyzed matched pre-ADT and post-ADT tissue samples via RNAseq analysis of 40 formalin-fixed paraffin-embedded (FFPE) patient-matched pre-ADT biopsy (Bx) and post-ADT radical prostatectomy (RP) prostate cancer samples. We observed strong upregulation of components of the MAPK pathway including FOS, FOSB, and JUN, as well as downstream targets of MAPK signaling. These data suggest that ADT may induce a compensatory increase in MAPK signaling in response to the decrease in androgen signaling. Thus, we hypothesize that combination therapies targeting AR and the MAPK pathway may synergistically kill prostate cancer cells and prevent recurrence and progression to CRPC. In the current study, we have tested the effects of the MEK inhibitors PD0325901 and GSK1120212, ERK1/2 inhibitor GDC-0994, and the JNK inhibitor AS602801 alone and in combination with enzalutamide in androgen-sensitive LNCaP and MDA-PCa-2b cells. Cell viability assays indicated that enzalutamide combined with MEK and JNK inhibitors synergistically killed LNCaP and MDA-PCa-2b cells, and decreased migration and invasion of LNCaP cell more than any of the drugs alone. We therefore propose that combination therapy targeting AR and MEK and/or JNK signal pathways may be an effective treatment for recurrent prostate cancer. We are currently investigating the most promising combinations of enzalutamide with JNK inhibitors for anti-tumorigenic effects in vivo using a mouse xenograft model. Citation Format: Zhenghong Li, Carrie Qi Sun, Rebecca Arnold, John A. Petros, Carlos S. Moreno. Combination therapies to prevent resistance to androgen deprivation therapies in prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 284.
Alterations in Epidermal Biochemistry As a Consequence of Stage-Specific Genetic Changes in Skin Carcinogenesis
Authors: Stuart H. Yuspa, Anne Kilkenny, Christina Cheng, Dennis Roop, Henry Hennings, Francis Kruszewski, Edmund Lee, James Strickland, David A. Greenhalgh
Journal: Environmental Health Perspectives (1991)

The induction of cancer on mouse skin by initiation-promotion protocols occurs through stages in which a benign squamous papilloma is an obligate precursor of squamous cell carcinoma. Activation of the Ha-ras gene is sufficient to produce the papilloma phenotype, while additional genetic changes are required for malignant conversion. The introduction of Ha-ras into normal keratinocytes suppresses the expression of differentiation markers, keratin K1 and K10, and loricrin (a cornified envelope precursor) and, to a lesser extent, filaggrin, at the level of transcription. However, cells initiated by Ha-ras express a nonepidermal keratin, K8. The transcription of K8 in these cells is sensitive to the level of medium Ca2+, being abundant in 0.5 mM Ca2+ and not detected in 0.05 mM Ca2+. Epidermal differentiation is regulated by signalling, which involves changes in phosphatidylinositol turnover and intracellular Ca2+. Cells initiated by Ha-ras do not differ from normal keratinocytes in their intracellular Ca2+ response patterns, at least in response to changes in extracellular Ca2+ and serum factors. However, c-Ha-ra keratinocytes have a high basal level of phosphatidylinositol (PI) turnover, which is additive with several other inducers of this pathway, including Ca2+ and aluminum fluoride. Additional studies suggest that high turnover of the PI pathway is incompatible with differentiation-specific gene expression in keratinocytes. We suggest this negative relationship is mediated through elevated diacylglycerol production and chronic down-modulation of protein kinase C. Protein kinase C is known to be essential for expression of differentiation-related genes in keratinocytes.(ABSTRACT TRUNCATED AT 250 WORDS)
Hepatitis C virus genotypes: An investigation of type-specific differences in geographic origin and disease
Authors: G Dusheiko
Journal: Hepatology (1994)

Because of the nucleotide sequence diversity of different isolates of hepatitis C virus, it has become important to clarify whether distinct genotypes of hepatitis C virus vary with respect to pathogenicity, infectivity, response to antiviral therapy and geographic clustering. We assessed nucleotide sequence variability in the 5′ noncoding region of hepatitis C virus, using restriction enzymes to analyze the distribution of hepatitis C virus genotypes, in 80 patients with chronic hepatitis C virus infection. Genotypes were correlated with demographic, clinical and histological features. Thirty-seven patients were infected with type 1, 10 had type 2 and 8 had type 3, and another 23 were infected with a new distinct hepatitis C virus type now classified as type 4. Two were infected with variants whose classification are uncertain. Types 1, 2 and 3 were found in patients from the United Kingdom, southern Europe, Asia, Africa and South America. Nineteen of 23 type 4 genotype isolates were from Middle Eastern patients, compared with 0 of 37 type 1 isolates (p < 0.001). Of 21 Middle Eastern patients, 19 (90.4) had type 4 hepatitis C virus (p = 0.001, odds ratio = 9). We found no significant difference between the mean ages or mean serum aminotransferase concentrations between the various types. Types 1,2,3 and 4 were found in patients with mild-to-moderate disease or severe disease. However, 21 of 29 (72.4) patients with type 1 who underwent liver biopsy had severe chronic hepatitis, cirrhosis or hepatocellular carcinoma histologically; 8 had mild or moderate chronic hepatitis without cirrhosis (p = 0.03, odds ratio = 2.6). Poor response to interferon-α was noted in patients with type 1 disease. Our data suggest significant geographic clustering of type 4 disease in the Middle East area. Although different hepatitis C virus genotypes can be encountered in both mild and severe disease, type 1 hepatitis C virus may have important clinical implications. The prognostic importance of these genotypes will require prolonged follow-up studies. (Hepatology 1994;19:13–18).
History in the medical curriculum. A clinical perspective
Authors: S. E. Shortt
Journal: JAMA (1982)

Since the 18th century, the inclusion of the history of medicine in the medical curriculum has enjoyed various justifications. Recent demands for a return to basic sciences suggest that history must be assessed in terms of its clinical rather than social relevance. This article, echoing Osier, argues that a knowledge of medical history will directly and uniquely enhance clinical competence. (<i>JAMA</i>1982;248:79-81)
Preferential Nuclear Accumulation of JAK2V617F In CD34+ but Not Granulocytic, Megakaryocytic or Erythroid Cells of Patients with Philadelphia-Negative Myeloproliferative Neoplasia
Authors: Ciro R Rinaldi, Paola Rinaldi, Adele Alagia, Marica Gemei, Vitalyi Senyuk, Nicola Esposito, Fabio Formiggini, Vincenzo Martinelli, Anthony R. Green, Giuseppina Nucifora, Fabrizio Pane
Journal: Blood (2010)
A fibrin net brings in kidney stone catch
Authors: R. S. Johnson
Journal: JAMA (1980)

Urologists at the University of Michigan have developed a method for more effectively removing kidney stones that is beginning to find widespread acceptance. The stones are entrapped by a human fibrin clot, and the clot is then removed through the same type of incision conventionally used for kidney stone removal. "Surgical removal of kidney stones can sometimes be very difficult, but this technique makes the complicated cases simpler," said L. Paul Sonda, MD, who developed this technique together with C. Peter Fischer, MD, and Ananias C. Diokno, MD, of the University of Michigan Medical School and affiliated hospitals, Ann Arbor. They reported their success in 65 patients at the American College of Surgeons clinical congress in Atlanta. Their scientific exhibit included a video teaching film of the procedure. "The surgical opening and exposure of the kidney follow the conventional procedure," Sonda told<i>JAMA</i>MEDICAL NEWS, "but after the kidney is
Prevention of Venereal Disease
Authors: E. B. Turner, O. May
Journal: BMJ (1919)

<b>SUMMARY:</b> We present the first description of CT of a meningioma of the mandible in the literature. Extracranial meningiomas are exceedingly rare. There have been 3 cases of meningioma of the mandible described in the literature, but none characterized with cross-sectional imaging. We describe the clinical and CT features used to establish the diagnosis as well as how to differentiate this lesion from other pathology of the mandible.
Morphine modulates contractile responses and neurokinin A-LI release elicited by electrical field stimulation or capsaicin in a guinea pig bronchial-tube preparation.
Authors: E G Lindström, R G Andersson
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Excitatory nonadrenergic, noncholinergic (e-NANC) bronchoconstrictor responses have been shown to be mediated by the release of tachykinins from sensory nerves. We investigated whether bronchial-tube contractions evoked by electrical-field stimulation (EFS) or capsaicin coincided with the release of neurokinin A (NKA). We also studied the modulatory action of morphine and the ability of naloxone to affect these responses. We used a guinea pig bronchial-tube preparation denuded of epithelium. The method allows simultaneous measurement of smooth-muscle tension and mediator release. A significant release of NKA-LI, at 37.3% above the basal level, was detected in response to EFS. Morphine pretreatment was found to inhibit the release, and such inhibition was not prevented by naloxone. Contractile responses to EFS coincided with the NKA-LI release. Capsaicin stimulation evoked a significant release (35.4%) of NKA-LI, and this release was accompanied by contractions. Treatment with morphine decreased capsaicin-induced responses, and naloxone reversed the inhibitory effect. In conclusion, both capsaicin- and EFS-induced e-NANC responses were inhibited by morphine treatment. This indicates presynaptic inhibition of tachykinin release from sensory nerves. Furthermore, the ability of naloxone to reverse this inhibitory effect differed in capsaicin- and EFS-challenged preparations.
Pneumocephalus as a consequence of barotrauma
Authors: R. W. Goldmann
Journal: JAMA (1986)

PNEUMOCEPHALUS has been noted in a variety of medical and surgical conditions. The most common etiology is accidental and iatrogenic craniofacial trauma, with an incidence of 74.9% in an extensive review of 295 cases by Markham.<sup>1</sup>Other causes include neoplasm (osteomas,<sup>2</sup>epidermoid tumors,<sup>3</sup>and pituitary tumors), spinal anesthesia.<sup>4</sup>infection,<sup>5</sup>and neurilemoma.<sup>6</sup>No cases of pneumocephalus associated with rapid pressure change have been documented previously, although Markham did report a patient in whom symptoms were exacerbated during altitude changes of some 540 m (1,800 ft). We report the case of a previously healthy scuba diver who experienced pneumocephalus likely on the basis of air trapping and barotrauma. <h3>Report of a Case</h3> A 26-year-old healthy male scuba diving instructor was referred to the St Luke's Hospital (Milwaukee) Department of Hyperbaric Medicine by the Duke University Divers Alert Network. The patient had been engaged in fresh water
Adenomatous Polypi of Large Intestine: Incidence and Distribution
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes in platelet kinetics after a partial splenic arterial embolization in cirrhotic patients with hypersplenism
Authors: H NOGUCHI
Journal: Hepatology (1995)

We performed a partial splenic arterial embolization in 22 patients with cirrhosis associated with thrombocy-topenia and then evaluated the changes in platelet kinetics after undergoing the procedure using 111In-tropolone–labeled platelets. The controls consisted of eight chronic hepatitis patients who showed a normal platelet count and normal spleen size. The mean splenic infarction ratio after the procedure was 54.9%. A platelet kinetics study was performed before and 2 months after the procedure. Before the procedure, the cirrhotic patients showed increases in the splenic volume and the spleen/liver uptake ratio of the 111In-labeled platelets on both the third and seventh days, and a decrease in the platelet recovery compared with the controls, which suggested an increased platelet pool in the spleen. In addition, the platelet survival time in cirrhotic patients was shortened, whereas the platelet-associated immuno-globulin G (PA-IgG) was higher than that of the controls, which suggested the involvement of immunologic mechanisms in the thrombocytopenia. With an increase of the platelet count after a partial splenic arterial embolization, the spleen/liver uptake ratio of the 111In-labeled platelets decreased, whereas the platelet recovery increased. Furthermore, the platelet survival time was prolonged, whereas the PA-IgG decreased. The platelet count showed a positive correlation with the platelet survival time and a negative correlation with PA-IgG before and after the procedure. These results suggest that a transcatheter splenic arterial embolization not only may reduce the increased platelet pool in the spleen but also may improve the thrombocytopenia induced by immunologic mechanisms in patients with cirrhosis. (Hepatology 1995; 22:1682-1688).
AIR BORNE INFLUENZA VIRUS
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal