tbuckley/cabot-search huggingface dataset:
"Mirror Speech."
Authors: J. T. Eskridge
Journal: JAMA (1897)

Denver, Colo, Feb. 21, 1897. <h3>To the Editor:</h3> —In the editorial comments of the issue of theJournalfor Dec. 19,1896, page 1307, you have a paragraph on "Mirror Speech," quoted from the Bulletin of the<i>Progrès Médical</i>, November 28, you do not state where the little patient was trephined, whether on the left or right side of the head or over what portion of the hemisphere. I have been engaged in working up speech defects of late and in one case, cyst of the brain, there was a transposition of the letters of words. The patient talked nearly normally, but writing was almost unintelligible from the transposition of the letters, but it was not "mirror speech." I will mail you a reprint of six cases of speech defect. The one that I refer to is the fourth case of the series. I shall feel greatly obliged for any additional
Correction: Error in Reference
Journal: Annals of Internal Medicine (1999)

Corrections2 February 1999Correction: Error in ReferenceFREESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-3-199902020-00025 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Reference 7 in a recent editorial on flock workers' lung (1) was from the International Journal of Occupational and Environmental Health, not the International Journal of Occupational Medicine and Environmental Health.Reference1. Davidoff F. New disease, old story [Editorial]. Ann Intern Med. 1998;129:327-8. LinkGoogle Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 February 1999Volume 130, Issue 3Page: 246KeywordsEnvironmental healthLungs ePublished: 15 August 2000 Issue Published: 2 February 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
In This Issue
Journal: Circulation Research (2010)

Regulation of cardiomyocyte polyploidy and multinucleation by Cyclin G1 (p 1498)Liu et al have discovered a potent promoter of polyploidy in rat hearts.Polyploidy-multiple copies of the genome in one cell-is normal in cardiomyocytes but can also be ramped up in pathological situations, such as cardiac hypertrophy or in regenerative situations, such as after heart injury.The ability to boost or suppress polyploidy might thus have a number of heart health implications.Cardiomyocytes in the mammalian embryo divide just like regular cells, but shortly after birth, they stop dividing and continue replicating their DNA, creating cells with multiple nuclei.This multinucleation period lasts for about 3 weeks in rats and about 10 years in humans.Liu et al discovered that in the postnatal multinucleation phase in rats, levels of cyclin G1 protein shot up, whereas levels of other cell cycle regulators dropped.Cyclin G1, the team showed, boosted polyploidy in newborn rat cardiomyocytes, whereas the lack of cyclin G1 prevented polyploidy in newborn mice.Without cyclin G1, these mice were also less capable of increasing the number of their nuclei in response to cardiac overload and hypertrophy.
Carbenoxolone sodium in the treatment of peptic ulcer. A review
Authors: J. R. Lewis
Journal: JAMA (1974)

THE dates on which several new therapeutic agents were introduced in the United States and Great Britain have recently been compared by Wardell.<sup>1</sup>He also conducted a survey on the usage of these new drugs by British physicians, and the awareness of them by American physicians.<sup>2</sup> Among the drugs available in Great Britain but not in this country, carbenoxolone sodium is notable for two reasons: (1) the "lead" time that it has been available in Great Britain is among the longest of the drugs surveyed (ten years), and (2) it is recognized as "the only drug therapy that has been shown unequivocally to promote the healing of gastric ulcers."1 Several reviews of carbenoxolone have appeared in the foreign literature<sup>3-6</sup>but, with the exception of one report on the proceedings of a symposium,<sup>7</sup>only a brief summary of the drug's actions by Wolf<sup>8</sup>has been published
Hematology
Authors: Jeanne M. Lusher
Journal: JAMA (1996)

Von Willebrand disease (vWD) affects an estimated 1% of the population, yet the condition is undiagnosed in many affected persons. Originally described by the Finnish physician Erik von Willebrand in 1926, this hereditary disorder is characterized by mucous membrane bleeding (epistaxis, gum bleeding, menorrhagia), excessive bleeding from superficial lacerations, surgery, or invasive dental procedures, and easy bruisability. Although inherited as an autosomal dominant trait, vWD presents more problems for young women, who often have excessive menstrual bleeding. Until recently, the pathogenesis of vWD was poorly understood, available diagnostic tests were controversial and difficult to interpret, and treatment options were limited. Fortunately, this has changed. We have a much clearer understanding of vWD,<sup>1-3</sup>better diagnostic tests, and safer, easy-to-use treatment modalities. These developments—especially for treatment—make it imperative that clinicians at least<i>think</i>of the possibility of vWD when seeing and evaluating patients with mucous membrane—type bleeding, with or without excessive
Airway fractal dimension predicts respiratory morbidity and mortality in COPD
Authors: Sandeep Bodduluri, Abhilash S. Kizhakke Puliyakote, Sarah E. Gerard, Joseph M. Reinhardt, Eric A. Hoffman, John D. Newell, Hrudaya P. Nath, MeiLan K. Han, George R. Washko, Raúl San José Estépar, Mark T. Dransfield, Surya P. Bhatt, COPDGene Investigators
Journal: Journal of Clinical Investigation (2018)
Chikungunya Fever
Authors: Joan Stephenson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIPG-26. NON-INFLAMMATORY EFFECT OF DIPG ON TUMOR-ASSOCIATED MICROGLIA
Authors: Grant Lin, Michelle Monje
Journal: Neuro-Oncology (2017)

Diffusely infiltrating high-grade gliomas are a class of central nervous system tumors that carry a dismal prognosis across all ages. In children, about half of these tumors arise within the ventral pons as diffuse intrinsic pontine glioma (DIPG), which has a peak incidence from ages 6–8 and only a 9–12 month median survival. Like adult gliomas, DIPG exhibits a significant expansion of myeloid cells, with microglia/macrophages accounting for ~30% of the tumor cell mass (Caretti & Monje, 2014). In adult glioma, these glioma-associated macrophages have been implicated as supporting angiogenesis and tumor cell invasion, proliferation, and survival (Glass & Synowitz, 2014). However, genomic and epigenomic characterizations of adult and pediatric high-grade gliomas have revealed striking differences in the molecular nature of these tumors (Sturm et al., 2014), and traditional chemotherapeutic approaches to adult glioblastoma are not effective in pediatric high-grade gliomas, suggesting these are unique diseases with distinct pathophysiology. Our data demonstrates that the cytokine secretion profiles of patient-derived DIPG cell cultures are dramatically less inflammatory when compared to patient-derived adult high-grade glioma cell cultures, and are more similar to the profile of human neural precursor cell cultures. Consistent with the observed non-inflammatory and possibly anti-inflammatory nature of DIPG, primary murine microglia exposed to DIPG-conditioned media exhibit significantly reduced phagocytosis compared to unconditioned media or adult GBM-conditioned media. This suggests that pathophysiological differences between adult and pediatric gliomas likely include their interactions with glioma-associated macrophages. By understanding the DIPG-microglial interaction in molecular detail, we will gain insight into the pathophysiology of DIPG that could direct future targeted therapies.
Update: Multistate Outbreak of Monkeypox—Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003
Journal: JAMA (2003)

CDC and state and local health departments continue to investigate cases of monkeypox among persons who had contact with wild or exotic mammalian pets or persons with monkeypox. This report updates epidemiologic, laboratory, and smallpox vaccine use data for U.S. cases, and summarizes the laboratory-based evidence implicating imported African rodents as the probable source of the outbreak.
New program targets death investigator training
Authors: R. Voelker
Journal: JAMA (1996)

A NEW TRAINING program that is based on an in-depth analysis of job skills may push death investigators closer toward national certification. The Death Investigator Training Program, spearheaded by Milwaukee County (Wisconsin) Medical Examiner Jeffrey Jentzen, MD, is an effort to boost the quality of death investigation throughout the United States. As part of their research in determining what's needed in such a curriculum, Jentzen and his colleagues conducted a national survey. "Only 60% of medical examiners across the country felt they were satisfied with their investigators. So we felt we needed to develop a training curriculum to improve their job performance," Jentzen said at the annual meeting of the American Academy of Forensic Sciences (AAFS) in Nashville, Tenn, where he described the program. <h3>Essential Skills Identified</h3> A recurring theme during the AAFS meetings is the lack of adequate training in death investigation. "Only in seven states is training mandated"
Allergy abstracts
Authors: David Stein Suffern, Harold Friedman, Andre Codispoti &fern, N Monroe, Coleman Stamford, C Glendora, Calif Eugene, Walzer Bridgeport, Conn Middleton, N Sheldon, Berger Freehold, N Robert, Y Lin, Jersey City, Nj Kahn
Journal: Journal of Allergy and Clinical Immunology (1983)
VENOUS THROMBOSIS AS A COMPLICATION OF PNEUMONIA.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anaphylaxis and Sensitization. With Special Reference to the Skin and Its Diseases.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemangioma of the small intestine with gastrointestinal bleeding
Authors: B. H. Hyun
Journal: JAMA (1969)

A 12-year-old boy had multiple hemangiomas of the small intestine. Severe chronic hypochromic microcytic anemia (iron deficiency anemia) with occult blood in the feces due to chronic blood loss was a presenting manifestation. Resection of individual hemangiomas at laparotomy resulted in cure of this condition. The possibility of intestinal hemangioma should be considered in the differential diagnosis of gastrointestinal hemorrhage and of intestinal obstruction. Exploratory laparotomy appears to be mandatory for the correct diagnosis and cure of the condition.
Effects of Parental PTSD on the Cortisol Response to Dexamethasone Administration in Their Adult Offspring
Authors: Rachel Yehuda
Journal: American Journal of Psychiatry (2007)

Objective: The authors used a low-dose dexamethasone suppression test to examine the effect of a PTSD risk factor, parental PTSD, on cortisol negative feedback inhibition in adult offspring of Holocaust survivors with PTSD (N=13) versus without PTSD (N=12) as well as a comparison group of offspring whose parents had no Holocaust exposure (N=16). Method: Blood samples were obtained at 8:00 a.m. for the determination of baseline cortisol. Participants ingested 0.5 mg of dexamethasone at 11:00 p.m., and blood samples were obtained again at 8:00 a.m. the following day. Results: Enhanced cortisol suppression in response to dexamethasone was associated primarily with parental PTSD status, with minimal contribution of subjects’ own trauma-related symptoms. Conclusions: Enhanced cortisol negative feedback inhibition may be associated with PTSD because it is related to the PTSD risk factor of parental PTSD.
Oncology Research Program
Authors: Kimberly Blackwell, Sarah Sammons, Paul Marcom, Kelly Westbrook, Gretchen Kimmick
Journal: Journal of the National Comprehensive Cancer Network (2017)

The goal of the Highlights of the NCCN Oncology Research Program (ORP) is to provide readers with more information on the ORP, including studies currently accruing patients.For more information on specific trials, including patient selection criteria, please use the contact information listed with each study.For more information on the NCCN ORP, including a complete detailing of the clinical studies currently underway at NCCN Member Institutions, please access the NCCN ORP pages at NCCN.org/clinical_trials/ clinicians.asp.
A Specific Spectrum of p53 Mutations in Lung Cancer from Smokers: Review of Mutations Compiled in the IARC p53 Database
Authors: Tina M. Hernandez-Boussard, Pierre Hainaut
Journal: Environmental Health Perspectives (1998)

Mutations in the p53 gene are common in lung cancer. Using data from the the International Agency for Research on Cancer p53 mutation database (R1), we have analyzed the distribution and nature of p53 mutations in 876 lung tumors described in the literature. These analyses confirm that G to T transitions are the predominant type of p53 mutation in lung cancer from smokers. The most frequently mutated codons include 157, 158, 179, 248, 249, and 273, and several of them (157, 248, and 273) have been shown to correspond to sites of in vitro DNA adduct formation by metabolites of polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene. Furthermore, most of the base changes at codons 248, 249, and 273 in lung cancer differ from those commonly observed at these codons in other cancers reported in the database. Thus, lung cancer from smokers shows a distinct, unique p53 mutation spectrum that is not observed in lung cancer from nonsmokers. These results further strengthen the association between active smoking, exposure to PAHs, and lung cancer. They also indicate that a different pattern of mutations occurs in nonsmokers, and this observation may help to identify other agents causally involved in lung cancer in nonsmokers.
Prospective and observational study of pain and analgesic prescribing in medical oncology outpatients with breast, colorectal, lung, or prostate cancer.
Authors: M. Fisch, J. Lee, M. Weiss, L. I. Wagner, V. T. Chang, D. Cella, J. Manola, L. M. Minasian, W. J. McCaskill-Stevens, T. R. Mendoza, C. S. Cleeland
Journal: Journal of Clinical Oncology (2011)

6008 Background: Pain is a prevalent symptom in cancer patients, yet pain management patterns in outpatient oncology are poorly understood. Methods: A total of 3,123 ambulatory patients with invasive cancer of the breast, prostate, colon/rectum, or lung were enrolled into a prospective observational study,regardless of phase of care or stage of disease. At initial assessment and 4-5 weeks later, patients completed a 25-item measure of pain, functional interference, and other symptoms. Providers recorded analgesic prescribing. The pain management index was calculated to assess treatment adequacy. Results: Sixty-seven percent of patients (2,026 of 3,023 patients at risk) expressed pain or required analgesics, and 670 of those had inadequate analgesic prescribing. Overall, 404 patients (13.4%) were prescribed strong opioids, and 584 patients (19.3%) had moderate or severe pain. Treatment adequacy did not change between the baseline and follow-up visits. For non-Hispanic white patients, the odds of having inadequate pain treatment were approximately half the odds for minority patients after adjusting for other explanatory variables in the multivariate model (odds ratio, 0.51; 95% CI, 0.37 to 0.70; p=0.002). Other significant predictors of inadequate pain treatment were good performance status, being treated at a minority treatment site, and having non-advanced disease without concurrent treatment. Conclusions: Most outpatients with common solid tumors must confront issues related to pain and the use of analgesics. There is significant disparity in pain treatment adequacy, with minority patients being twice as likely to be undertreated. These findings persist over one month of follow-up, highlighting the complexity of these problems.
Congenital Orotic Aciduria
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obstetrics for Nurses.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obituary
Authors: Louis H. Felder
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal