tbuckley/cabot-search huggingface dataset:
Who was Daniel Drake?
Authors: L. S. King
Journal: JAMA (1985)

In American history the key word is<i>expansion</i>. The original 13 colonies were settled on the Eastern Seaboard, limited, for practical purposes, by the Appalachian Mountains. Well before the Revolution, solitary pioneers, of whom Daniel Boone was the most famous, did indeed carry out important explorations across the Appalachian Mountains, but penetration westward remained halting and irregular until after the colonies became welded into a new nation. As with virtually all folk migrations, population pressures induced hardy and ambitious settlers to seek new land, new opportunities. Physical difficulties of terrain, and the hostility of Indians whose lands were being ruthlessly seized, served as counterbalancing forces, but population pressures were not to be denied. The new government had wisely established what might be called a reservoir of land open to settlers. In the latter 18th century the best route to the so-called Northwest Territory lay along the Ohio Valley. Roads were
Worlds Apart
Authors: Keith E. Ellis
Journal: JAMA (1987)

<h3>To the Editor.—</h3> How wonderful and exciting it is when an idea whose time has come finally is espoused by even the most hardened of opponents. Howell et al,<sup>1</sup>in a SPECIAL COMMUNICATION in the July 24/31 issue of<i>JAMA</i>, have said it so well: the teaching of ambulatory care finally is gaining its rightful importance. We who have been practicing family and primary care medicine have been relying for years on our ambulatory care skills to provide good solid medical care at a reasonable cost. However, most of our ideas about the importance of teaching ambulatory care to medical students and residents have fallen on deaf ears; our ideas are being especially ignored by our closest colleagues and allies, internists. Until the family practice movement, good resident teaching had to involve only patients who were horizontal and not those who were vertical. Happily, that's all changing. Michael Balint
DRUGGIST ETHICS.
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Idiopathic Pulmonary Fibrosis
Authors: R. du Bois
Journal: Annual Review of Medicine (1993)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
A Phase I/II Trial Evaluating The Use Of a Histone Deacetylase Inhibitor Panobinostat (LBH589) In Addition To Glucocorticoids In Patients With Acute Graft-Versus-Host Disease
Authors: Lia Perez, Hugo F Fernandez, Marcie Tomblyn, Frederick L Locke, Teresa Field, Joseph Pidala, Erika Elmer, Francisca Beato, Alejandro Villagra, Claudio Anasetti
Journal: Blood (2013)
GERMICIDAL PLASTICS
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Excretion of f2-isoprostanes in bile: A novel index of hepatic lipid peroxidation*1
Authors: J AWAD
Journal: Hepatology (1995)

Lipid peroxidation is believed to be an important mechanism of liver injury caused by some xenobiotics. However, it has been difficult to demonstrate and quantify this process in vivo. Moreover, little is known about the disposition of lipids oxidized in the liver. F2-isoprostanes are prostanoids produced by nonenzymatic free radical—catalyzed peroxidation of arachidonic acid esterified to phospholipids. Hydrolysis of F2-isoprostanes from phospholipids by phospholipases yields free F2-isoprostanes. Excretion of F2-isoprostanes, both free and esterified to phospholipids, was measured in bile after administration of CCI4. The concentration of lipid-esterified F2-isoprostanes in bile exceeded that of free F2-isoprostanes. CCI4 caused a dose-dependent increase in biliary F2-isoprostane excretion that correlated better with the increase in liver F2-isoprostanes than it did with the increase in plasma F2-isoprostanes. Pretreatment with colchicine ameliorated CCI4-liver injury but did not affect baseline or CC14-induced biliary F2-isoprostane excretion. Administration of diquat to selenium-deficient rats, which causes hepatic and renal necrosis, was associated with a 13-fold elevation of plasma F2-isoprostanes. However, both hepatic F2-isoprostane concentrations and biliary F2-isoprostane excretion were increased only threefold. These data suggest that quantification of F2-isoprostane excretion in bile may provide a sensitive and quantitative index of hepatic lipid peroxidation.
A. C. P. COMMITTEES AND REGENTS TO MEET
Journal: Annals of Internal Medicine (1940)

College News Notes1 October 1940A. C. P. COMMITTEES AND REGENTS TO MEETAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-4-744 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBy direction of the President, the various Committees and the Board of Regents of the College will meet at the College Headquarters in Philadelphia, December 14-15, 1940, for the transaction of the regular mid-year business.Among many important matters to be considered will be the statement of operation, the adoption of 1941 budgets, election of candidates to membership, the selection of the recipient of the John Phillips Memorial Award for 1941, adoption of the program of postgraduate and refresher courses for 1941 and final arrangements for the Twenty-fifth Annual Session of the College in Boston.GIFTS TO THE COLLEGE LIBRARY This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1940Volume 14, Issue 4Page: 744-756 ePublished: 1 December 2008 Issue Published: 1 October 1940 PDF downloadLoading ...
Importance of Pure Water.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Special Contribution
Authors: Ashley Montagu
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lost Words
Authors: Luming Li
Journal: Annals of Internal Medicine (2012)

Ad Libitum15 May 2012Lost WordsLuming Li, BALuming Li, BAFrom Piscataway, NJ 08854.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-10-201205150-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In a grey, makeshift clinic,A newly born baby with a tiny, beet-red facedrew an audience of curious nurses, who pitied her.No one took her home on that scorching, arid day.Her mother—a malnourished woman couldn't afford to careHer father—unknownBorn to unkind, bruised country,The little girl's withered toes and fingers were fused,and her pale spine was deeply curved.But her eyes were big, bright fireflies,glimmering occasionally even between harsh cries.As the dotted stars dimly rose on that long, forlorn night,Her small frame fadedNo one to play kaleidoscope gamesNo one to whisper soft reveriesLuming Li, BAPiscataway, NJ 08854... Author, Article, and Disclosure InformationAffiliations: From Piscataway, NJ 08854.Current Author Address: Luming Li, BA; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 2012Volume 156, Issue 10Page: 719KeywordsGamesSpine ePublished: 15 May 2012 Issue Published: 15 May 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Néphropathies et néphrites: Leçons cliniques
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epithalamium
Authors: Arthur Ginsberg
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>QuickStats:</i> Percentage* of Currently Employed Adults Aged 18–64 Years Who Have Paid Sick Leave,† by Poverty Status§ — National Health Interview Survey,¶ United States, 2008 and 2018
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

PercentageYear Total <100% of poverty threshold 100%-199% of poverty threshold 200%-399% of poverty threshold ≥400% of poverty threshold * With 95% confidence intervals indicated with error bars.† Based on a positive response to the question "Do you have paid sick leave on this main job or business?"§ Poverty status was based on family income and family size using the U.S. Census Bureau poverty thresholds.Family income was imputed when missing.¶ Estimates are based on household interviews of a sample of the civilian, noninstitutionalized U.S. population and are derived from the National Health Interview Survey Sample Adult component.The percentage of currently employed adults aged 18-64 years who have paid sick leave increased from 57.8% in 2008 to 61.7% in 2018.For both 2008 and 2018, the percentage of employees with paid sick leave increased with family income.In 2018, the percentage with paid sick leave was 31.5% for those with incomes <100% of the poverty threshold, increasing to 71.4% for those with incomes ≥400% of the poverty threshold.The percentage of employees with paid sick leave increased from 2008 to 2018 in all poverty groups, although the increase was not significant for those with incomes <100% of the poverty threshold or for those with incomes ≥400% of the poverty threshold.
Abstract 16408: Acute Changes in Tricuspid Annular Plane Systolic Excursion and Myocardial Deformation in Fetuses With Twin-twin Transfusion Syndrome After Selective Fetoscopic Laser Therapy
Authors: Betul Yilmaz, Ryan A Moore, Christopher J Statile, Regina Keller, Foong-Yen Lim, Erik C Michelfelder
Journal: Circulation (2015)

Introduction: Twin-twin transfusion syndrome (TTTS) is a serious complication affecting 10-15% of monochorionic twin gestations. Right ventricle (RV) function is often abnormal in these fetuses. Tricuspid annular plane systolic excursion (TAPSE) and myocardial strain are used as a marker of RV function in a number of disease processes postnatally. Hypothesis: Monitoring TAPSE and myocardial deformation may aid in assessing response to selective fetoscopic laser therapy (SFLP) in TTTS. Our objective was to determine whether TAPSE and myocardial deformation are altered after SFLP. Methods: Fetal echocardiograms of 22 recipient (RT) and donor (DT) twin pairs with TTTS were prospectively evaluated. TAPSE was obtained via M-mode through the lateral tricuspid annulus in the vertical 4-chamber (4C) view. 2D 4C views were acquired utilizing high frame rates (&gt;30 frames/sec) and were interrogated offline using feature-tracking software for strain analysis. Global RV longitudinal strain, TAPSE, and myocardial performance index (MPI) were compared pre and post-SFLP. Reproducibility of both TAPSE and RV strain was assessed. Results: Initial fetal echo was performed at 20.8 ± 2.3 weeks gestation. Median time between initial study and post-SFLP was 7 days (interquartile range 1 to 11 days). DT showed a slight improvement in strain, but not in TAPSE post-SFLP (Table). There was a significant, acute improvement both in global longitudinal strain and TAPSE among RT after SFLP (Table). Interobserver variability for TAPSE and strain was 4% vs 36%, respectively. Conclusion: After SFLP, there is an acute improvement in the global RV strain and TAPSE in RT, consistent with improved RV long-axis function or loading conditions. TAPSE is feasible in most fetuses, and is considerably more reproducible than myocardial strain. Further work examining the relationship between RV function and outcome post-SFLP is warranted in TTTS population.
Errors in Byline and Affiliations
Journal: JAMA Network Open (2020)

Marlies Ostermann, MD, PhD; Alexander Zarbock, MD; Stuart Goldstein, MD; Kianoush Kashani, MD, MSc; Etienne Macedo, MD, PhD; Raghavan Murugan, MD; Max Bell, MD, PhD; Lui Forni, PhD, MBBS; Louis Guzzi, MD; Michael Joannidis, MD, PhD; Sandra L. Kane-Gill, PharmD, MSc; Matthieu Legrand, MD, PhD; Ravindra Mehta, MD; Patrick T. Murray, MD; Peter Pickkers, MD, PhD; Mario Plebani, MD; John Prowle, MD; Zaccaria Ricci, MD; Thomas Rimmelé, MD, PhD; Mitchell Rosner, MD; Andrew D. Shaw, MB; John A. Kellum, MD; Claudio Ronco, MD
PARIS
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OYSTERS AND TYPHOID FEVER
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multidrug Resistance1
Authors: J. A. Moscow, K. H. Cowan
Journal: JNCI Journal of the National Cancer Institute (1988)

The ability of malignant cells to develop resistance to cytotoxic drugs poses a major obstacle to the ultimate success of cancer therapy. While some mechanisms of resistance allow cells to survive exposure to a single agent, the phenomenon of multidrug resistance (MDR) confers upon cells the ability to withstand exposure to lethal doses of many structurally unrelated antineoplastic agents. MDR has been strongly linked to the overexpression of a membrane-associated glycoprotein, P-glycoprotein, which appears to play a role in drug efflux. However, several lines of evidence suggest that other mechanisms of resistance are involved in MDR; biochemical similarities observed in a human breast cancer cell line after the acquisition of MDR and in carcinogen-induced rat preneoplastic hepatic nodules indicate that changes in regulation of phase I and phase II drug-metabolizing enzymes may also play a role in MDR. An atypical pattern of MDR has been characterized and related to altered topoisomerase activity. Improvement in current cancer chemotherapy may be achieved by interfering with the regulation and expression of mechanisms of MDR. [J Natl Cancer Inst 1988;80:14–20]