tbuckley/cabot-search huggingface dataset:
Platelet concentrates have a very high ammonia content: Implications for platelet transfusions in patients with cirrhosis , Jefferson Medical College, Philadelphia, PA
Journal: Hepatology (1995)

VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells.Vascular endothelial growth factor (VEGF) regulation of endothelial nitric oxide synthase (eNOS) and signaling pathways involved have not been well studied in glomerular endothelial cells (GENCs).GENCs grown from tsA58 Immortomice® were used. Immunoblotting and in-cell Western blot analysis were employed to assess changes in VEGF receptor signaling pathway and eNOS phosphorylation of ser1177. Immunokinase assay and immunoblotting with phosphospecific antibodies were performed to assess activity of kinases.VEGF rapidly induced tyrosine phosphorylation of type 1 and type 2 VEGF receptors. Physical association between VEGF-receptor 2 (VEGF-R2) and insulin receptor substrate (IRS-1) and phosphatidylinositol 3′-kinase (PI3K) was induced by VEGF, which augmented PI3K activity in VEGF-R2 immunoprecipitates. VEGF stimulated Akt phosphorylation in a PI3K-dependent manner. VEGF increased eNOS phosphorylation on Ser1177. Activation of eNOS was associated with nitric oxide generation as measured by medium nitrite content. Signaling mechanisms involved in VEGF stimulation of eNOS were explored. VEGF-induced eNOS phosphorylation was abolished by SU1498, a VEGF-R2 inhibitor, LY294002, a PI3K inhibitor, and infection of cells with an adenovirus carrying a dominant negative-mutant of Akt, demonstrating the requirement of the VEGF-R2/IRS-1/PI3K/Akt axis for activation of eNOS. VEGF also activated extracellular signal-regulated protein kinase (ERK) in a time-dependent manner; and VEGF-stimulated eNOS phosphorylation on Ser1177 was prevented by PD098059, an upstream inhibitor of ERK, demonstrating that ERK was involved in VEGF regulation of eNOS. ERK phosphorylation was abolished by LY294002, suggesting ERK was downstream of PI3K in VEGF-treated GENC.Our data demonstrate that in GENC, VEGF stimulates VEGF-R2/IRS-1/PI3K/Akt axis to regulate eNOS phosphorylation on Ser1177 in conjunction with the ERK signaling pathway.
Le sixième sens. (Sens génésique). Organes de la génération. Fonction sexuelle. Aberrations génitales. Curiosités relatives aux seins.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Znachenie vypadeniya funktsii selezenki v razvitii kholesterinemii i fosfatidemii, eksperimentalnoe issledovanie k voprosu o mozgovom proiskhozhdenii lipoidemii
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Manuscripts Approved for JNCI, March 1 to April 1, 1969
Journal: JNCI Journal of the National Cancer Institute (1969)

Manuscripts Approved for JNCI, March 1 to April 1, 1969 JNCI: Journal of the National Cancer Institute, Volume 42, Issue 5, May 1969, Pages 879–880, https://doi.org/10.1093/jnci/42.5.879-a Published: 01 May 1969
Multicenter Phase II Trial of Patients with Refractory or Recurrent Multiple Myeloma with Oral Treatment of Thalidomide Combined with Oral Cyclophosphamide, Idarubicin and Dexamethasone.
Authors: Axel Glasmacher, Thomas Moehler, Hartmut Goldschmidt, Thomas Geer, Rolf Kleinschmidt, Tobias Gaska, Janssens Uwe, Jorg Schubert, Patrick Bruck, Michael R. Clemens, Wolfgang Bair, Gernot Seipelt, Michael Schleuning, Corinna Hahn-Ast, Susanne Herz, Marie von Lilienfeld-Toal, Ralf Naumann, Marcus Gorschluter, Ingo G.H. Schmidt-Wolf
Journal: Blood (2007)
NEW MASSACHUSETTS LAWS RELATIVE TO COMMITMENT OF THE INSANE.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isolation and purification of large quantities of fresh human kupffer cells, which are cytotoxic against colon carcinoma
Authors: G HEUFF
Journal: Hepatology (1995)

A new rapid method is described for the isolation and purification of functional active human Kupffer cells without the need of in situ perfusion techniques. Liver wedge biopsies (3 to 5 g), obtained after laparotomy, were incubated with pronase under continuous pH registration. Human Kupffer cells were subsequently separated from other nonparenchymal cells by Nycodenz gradient centrifugation and purified by counterflow centrifugal elutriation. Kupffer cells, 1.7 ± 0.4 × 106 per gram liver, were isolated with a purity of 95% ± 3%. Cell-mediated cytotoxicity of Kupffer cells was assayed against a human colon carcinoma cell line (SW948). Kupffer cell cytotoxicity was 42% ± 9% (mean ± SD) at an effector-to-target cell ratio of 10 and significantly increased to 73 ± 17% (P < .05) after activation of Kupffer cells with interferon-gamma. In conclusion, a reliable and relatively simple method is provided to isolate and purify fresh human Kupffer cells in large yields, which show spontaneous as well as gamma-interferon-induced cytotoxicity against a human colon carcinoma cell line.
If mother has insulin-dependent diabetes, is child protected?
Authors: C. A. Raymond
Journal: JAMA (1988)

NOW FOR SOME good news about children born to mothers with insulin-dependent diabetes mellitus (IDDM). They may be relatively protected from that disorder themselves, says a recent study. If its results are confirmed, it might someday be possible to immunize children against this form of diabetes mellitus, says principal investigator James Warram, PhD, of Boston. An expert on the effects of diabetic pregnancies says the study is further affirmation that the uterine environment can modify one's genetic heritage. "The uterus is an incubator with a variable metabolism," says Norbert Freinkel, MD, Kettering Professor of Medicine at Northwestern University Medical School, Chicago. "Permanent effects can result from modification of phenotypic gene expression by [the] uterine metabolism." A few years ago, Warram and colleagues at Boston's Joslin Diabetes Center uncovered some interesting statistics. Using patient records to follow up children born to parents with juvenile-onset IDDM, they found that 6% of the
Shortage of Tetanus and Diphtheria Toxoids
Journal: JAMA (2000)

A temporary shortage of adult tetanus and diphtheria toxoids (Td) in the United States has resulted from two coincident situations: 1) a decrease in the number of lots released by Wyeth Lederle (Pearl River, New York), and 2) a temporary decrease in inventory of vaccine following routine maintenance activities at the production facilities by Aventis Pasteur (Swiftware, Pennsylvania) that lasted longer than anticipated. Approximately one half of the usual number of Td doses has been distributed this year. Although there have been no decreases in production of tetanus toxoid (TT), availability is low because of increased use during the Td shortage. On the basis of information provided by Aventis Pasteur, the Public Health Service expects vaccine supplies to be restored early in 2001. Until then, Aventis Pasteur will be limiting orders to assure the widest possible distribution of available doses.
Cholera in Europe.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Emphasis Placed on Drug Treatment for Shock
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phosgene Poisoning
Authors: E. Dale Everett
Journal: JAMA (1968)

Phosgene inhalation is uncommon but potentially lethal. Severe pulmonary edema with a decrease in plasma volume and severe hypoxemia results. The magnitude of severity may be delayed up to 24 hours following exposure. Successful management of massive exposure to phosgene was attained by monitoring vital capacity, arterial blood gases, replacement of fluid volume, administration of aminophylline and hydrocortisone, and intermittent positive pressure breathing.
FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3
Authors: Liqing Wang, Yujie Liu, Rongxiang Han, Ulf H. Beier, Tricia R. Bhatti, Tatiana Akimova, Mark I. Greene, Scott W. Hiebert, Wayne W. Hancock
Journal: Journal of Clinical Investigation (2015)

An investigation by the University Health Network recently found that portions of the RT-PCR gels shown in Figure 1, B (PGK-1 panel) and C (FGFR1 panel), are duplicated in this publication and in a subsequent publication (1).The samples were labeled differently in the panels, and the marker was shifted in Figure 1B.The corresponding author has indicated that other data from the initial screen of these samples support the conclusions made in the paper; however, the original data for the RT-PCR gels shown in Figure 1 are no longer available.The JCI's policies prohibit data manipulation and data duplication.Therefore, the JCI is retracting this article.No issues have been raised in regard to any of the other data in this manuscript.
443. Successful Long-Term Doxycycline-Regulated Transgene Expression in the Retina of Nonhuman Primates Following Subretinal Injection of Recombinant AAV Vectors
Authors: Knut Stieger, Guylène Le Meur, Francoise Lasne, Michel Weber, Jack-Yves Deschamps, Delphine Nivard, Alexandra Mendes-Madeira, Nathalie Provost, Laurent Martin, Philippe Moullier, Fabienne Rolling
Journal: Molecular Therapy (2006)
HEALTHFULNESS OF THE LAKE REGION.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 516: Pathologic Remodeling of Myocardial Cardiolipin in a Porcine Model of Diet-Induced Obesity and Insulin Resistance
Authors: Genevieve Sparagna, Ya Xu, Li Lu, Adam Chicco, Bryan Bergman, Gregory G Schwartz
Journal: Circulation (2007)

Background: Cardiolipin is a dimeric phospholipid required for normal mitochondrial function. The majority of cardiolipin molecules contain four linoleic acid (18:2) residues. Pathologic decrease in (18:2) 4 cardiolipin content has been associated with cardiomyopathy. Patients with obesity and insulin resistance have poorer outcomes after myocardial infarction compared with lean subjects. In the present study, we determined if cardiolipin content and composition are altered in a new porcine model of diet-induced obesity and insulin resistance. Methods: Yucatan micropigs (n=16) were assigned to a control diet (4% w/w fat, 2% simple sugars, quantity fed 30 g/kg/day) or an intervention diet (25% fat from coconut oil, 17% simple sugars, 50 g/kg/day) for 7 months. Pigs were then anesthetized and subjected to 45 min low-flow myocardial ischemia and 120 min reperfusion (I/R, n=11). Regional myocardial external work and O 2 consumption were measured. After euthanasia, neutral lipid content in myocardial samples was assayed by solid phase extraction and gas chromatographic mass spectrometry, and cardiolipin species were quantified by electrospray ionization mass spectrometry. Results: Compared with controls, the intervention diet group recapitulated characteristics of the clinical “metabolic syndrome” with obesity (73 ± 4 vs 40±4 kg), insulin resistance by glucose tolerance testing, hypertension, and hyperlipidemia. There was abnormal substitution of saturated fatty acyl moieties in all myocardial lipid pools. Myocardial content of normal cardiolipin (18:2) 4 was reduced by an average of 13% (p=0.02), while several smaller pools of abnormal cardiolipin species were increased. For example, cardiolipin with one myristic acid residue substituted for a linoleic acid residue was increased by an average of 400% (p=0.001). After I/R, external work was approximately 20% lower (p=0.2) and MVO 2 was 50% lower (p=0.07) in the intervention diet group. Conclusions: Pigs fed a diet high in saturated fat and energy content for 7 months develop a phenotype resembling the clinical metabolic syndrome. This is accompanied by pathologic remodeling of myocardial cardiolipin, which in turn may contribute to decreased contractile and metabolic performance after I/R.
Brain metastases in small cell carcinoma of the lung
Authors: R. E. Burgess
Journal: JAMA (1979)

The records of 177 patients with small cell carcinoma of the lung were reviewed to determine parameters associated with brain metastases. Complete autopsy, including examination of the brain, was done in each case. Of the 70 cases of brain metastases, only two patients (3%) were aged 70 years or more as compared with 19 (18%) aged 70 years or more who did not have brain metastases. Patients with brain metastases had a longer median survival as compared with those without brain metastases. Patients with brain metastases had involvement of the thyroid and kidney more frequently (23% and 34%, respectively) compared with patients without brain metastases (8% and 13%). Thus, patients who have brain metastases tend to (1) be less than 70 years of age; (2) have a longer survival; and (3) have a higher incidence of metastases to the thyroid and kidney. (<i>JAMA</i>242:2084-2086, 1979)
Fluorouracil as an Adjuvant to Colorectal Cancer Surgery-Reply
Authors: Min C. Li
Journal: JAMA (1976)

Drs Hansen and Stein raised the question as to the validity of using historical controls to assess a new therapeutic modality. The authors are very well aware of the merit and pitfalls of concurrent randomized studies. In many situations, the circumstances do not permit a concurrent randomized control, or, if the historical control is very much compatible with the studied groups, historical control may be the only valid background. For example, in the successful treatment of gestational choriocarcinoma with the chemotherapy, the initial treatment of Wilms tumor with chemotherapy and radiotherapy during the postoperative period, and even radiotherapy for stage I and stage II Hodgkin disease, there were no concurrent randomized controls. In addition, the effect of digitalis on congestive heart failure, the effect of adrenal steroids on adrenal crisis, and the effect of insulin on diabetic coma are all examples. To go a step further, when a
Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus
Authors: Stephen E. Gitelman
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infinite Jest
Authors: C. Shuker
Journal: BMJ (2011)

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The prevalence of gallstone disease in very old institutionalized persons
Authors: J. Ratner
Journal: JAMA (1991)

We present the results of a study that was undertaken at a large geriatric nursing home to assess the prevalence of gallstone disease in very old institutionalized persons. One hundred seventeen residents underwent ultrasound examination of the gallbladder. Two thirds of 82 women and half of 35 men had gallstone disease. When stratified for age, 80% of women and men over the age of 90 years were positive for the disease. In summary, the prevalence of gallstone disease in our very old nursing home population was found to be unexpectedly high. (<i>JAMA</i>. 1991;265:902-903)