tbuckley/cabot-search huggingface dataset:
Table of Contents
Authors: J Banuelos, Y Cao, S Shin, N Lu, S Dhami, H Zaman, E.-M Varga, G Sturm, A Muraro, C Akdis, D Antolín-Amérigo, M Bilò, D Bokanovic, M Calderon, E Cichocka-Jarosz, J Elberink, R Gawlik, T Jakob, M Kosnik, J Lange, E Mingomataj, D Mitsias, H Mosbech, M Ollert, O Pfaar, C Pitsios, V Pravettoni, G Roberts, F Ruëff, B Sin, M Asaria, G Netuveli, A Sheikh, T Czarnowicki, L Santamaria-Babí, E Guttman-Yassky, K Puan, A Andiappan, B Lee, D Kumar, T Lai, G Yeo, D Bercin, M Starke, D Haase, J Lum, F Chew, J Connolly, S Wong, F Zolezzi, M Poidinger, D Wang, O Rötzschke, F Sánchez-Gómez, J González-Morena, Y Vida, E Pérez-Inestrosa, M Blanca, M Torres, D Pérez-Sala, J Baek, J Roh, Y Jung, T Boonpiyathad, N Meyer, M Moniuszko, M Sokolowska, A Eljaszewicz, O Wirz, M Tomasiak-Lozowska, A Bodzenta-Lukaszyk, K Ruxrungtham, W Van De Veen, H Hochwallner, U Schulmeister, I Swoboda, M Focke-Tejkl, R Reininger, V Civaj, R Campana, J Thalhamer, S Scheiblhofer, N Balic, F Horak, N Papadopoulos, S Quirce, Z Szepfalusi, U Herz, E Van Tol, S Spitzauer, R Valenta, J Vidal-Quist, F Ortego, P Castañera, P Hernández-Crespo, Y Okamoto, S Fujieda, M Okano, Y Yoshida, S Kakudo, K Masuyama, Defi Ciency, T Rubic ´-Schneider, N Carballido-Perrig, C Regairaz, L Raad, S Jost, C Rauld, B Christen, G Wieczorek, R Kreutzer, J Dawson, G Lametschwandner, A Littlewood-Evans, J Carballido, L Grabenhenrich, A Reich, J Bellach, V Trendelenburg, A Sprikkelman, K Grimshaw, S Sigurdardottir, M Kowalski, R Dubakiene, B Niggemann, M Fernández-Rivas, B Ballmer-Weber, R Van Ree, S Schnadt, E Mills, T Keil, M Calderón, C Vidal, P Rodríguez, Del Río, J Just, A Tabar, I Sánchez- Machín, P Bubel, J Borja, P Eberle, R Reiber, M Bouvier, A Lepelliez, L Klimek, P Demoly, M Portelli, C Moseley, C Stewart, D Postma, P Howarth, J Warner, J Holloway, G Koppelman, C Brightling, I Sayers, R Schlosser, T Smith, J Mace, Z Soler, Y Mostmans, M Grosber, M Blykers, P Mols, N Naeije, J Gutermuth, G Cortellini, A Romano, A Santucci, A Barbaud, S Bavbek, D Bignardi, P Bonadonna, M Costantino, J Laguna, C Lombardo, L Losappio, J Makowska, A Nakonechna, O Quercia, E Pastorello, V Patella, I Terreehorst, S Testi, J Cernadas, J Elera, D Lippolis, S Voltolini, D Grosseto, K Jeong, S.-Y Lee, K Ahn, J Kim, H.-R Lee, D Suh, B.-Y Pyun, T Min, J.-W Kwon, K.-E Kim, M Sohn, Y Kim, T Song, Y Jeon, H Kim, Y Ahn
Journal: Allergy (2017)
Germs
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
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Authors: Sandra Gross-Schulman, David Dassey, Laurene Mascola, Carlos Anaya
Journal: JAMA (1998)

additional antibiotics were given.In October, the patient continued to be ill with boils on his legs, arm, abdomen, and hip, and brought his 10-year-old son, who had similar abscesses on his nostril, ear lobe, and elbow.A culture of a draining leg abscess taken from the patient and cultures taken from the elbow and nose of the child were positive for MRSA.The patient was treated with ciprofloxacin and rifampin, while his son was treated with oral erythromycin.Lesions resolved for both individuals with treatment.Neither patient had any known underlying risk factor for MRSA.The county health department was contacted for consultation.Family history revealed that, since 1993, other children in the household were affected periodically with lesions that had spontaneous, untreated remissions, while the patient's wife had abscesses that resolved when she took an unknown oral antibiotic.She alone had visited her 70-year-old stepfather in a community hospital in March 1997.His medical records indicated that he was treated for MRSA-positive leg lesions.Anecdotally, the family said that other Samoan community members, both in California and in Samoa, frequently had similar skin infections.Frequently, staphylococcal infection is preceded by mucosal or skin colonization of the same strain. 2Since the ecological niche of S aureus is the anterior nares, 3 we recommended obtaining culture specimens from all family members to show familial transmission of the same strain of MRSA.However, only the patient agreed to have skin and anterior nasal cultures taken.His October 1997 posttreatment nasal culture was still MRSA positive.The isolates from the son and the stepfather were unavailable for comparison.Hollis et al 4 reported intrafamilial transmission of a single strain of MRSA to demonstrate that family members can serve as reservoirs of MRSA.These authors treated carriers with intranasal mupirocin but cautioned against its routine use for decolonization because of concerns about resistance.In our investigation, since none of the family members had any known risk factors, we recommended that the patient obtain follow-up care with his primary care physician if similar infections recurred.Tropical pyomyositis, a disease characterized by skeletal muscle abscesses usually associated with isolation of S aureus, is endemic in Samoa but has been reported from temperate regions as well. 5Further investigation of treatment of abscesses in this population should be pursued.We are concerned about the public health impact of possible spread of drug-resistant disease to susceptible populations and advocate that standard protocols be implemented by health care providers to contain and control MRSA.
Ethnic and sex differences in selection for admission to Nottingham University Medical School
Journal: BMJ (1999)

strong association between being a bully or being bullied, depression, and severe suicidal ideation highlights the importance of further investigations into the social, psychological, and environmental factors associated with bullying. ConclusionTeachers and clinicians should recognise that being bullied or being a bully are signs of an increased risk of depression and suicidal behaviour among adolescents.Adolescents should be asked if they are involved in bullying either as a victim or as a bully.Whether an intervention is needed to treat depression should be assessed among both bullies and those who are being bullied.A cross disciplinary approach is needed to identify effective interventions to prevent bullying and depression and to reduce the risk of suicide while keeping in mind the close association between these phenomena.Contributors: RK-H developed and coordinated the formulation of the primary study hypothesis, discussed the core ideas, and participated in planning the collection of data, analysing the data, and writing the paper.MR initiated the school health promotion study and the inclusion of mental health questions in the survey, he discussed the core ideas, and participated in analysing the data and writing the paper.MM brought to the discussion about the core ideas of the study his expertise as a researcher on adolescent suicide and depression, and participated in designing the study, analysing the data, and writing the paper.AR discussed the core ideas of the school health promotion study as well as of this present report, and brought to the process her expertise as an epidemiologist; she also helped analyse the data and write the paper.PR discussed the core ideas of the study and supported the formulation of the hypothesis from the point of view of a clinical adolescent psychiatrist, and participated in writing the paper.MR will act as guarantor for the paper.
Firearm training and storage
Authors: E. A. Suter
Journal: JAMA (1995)

<h3>In Reply.</h3> —We surveyed a nationally representative sample of 800 US gun owners. We found that 21% kept a gun both loaded and unlocked in the home. Individuals who had received formal firearms training were significantly more likely to store a gun in this potentially unsafe manner. Practically everything Dr Suter asserts in his letter is wrong. Contrary to his claim, we clearly differentiated adult-only homes and we explored the relationship between gun storage and the perceived risk of attack. We reported that guns were stored loaded and unlocked in 14% of gun-owning homes with children present, compared with 26% of gun-owning homes without children. Keeping a gun loaded and unlocked was significantly more likely when protection was one of the reasons for gun ownership. Still, a gun was kept loaded and unlocked in 13% of homes where protection was not one of the reasons for ownership. And in a
Amphetamine theft.
Authors: R. B. Roe
Journal: BMJ (1969)

try, knowing that consultant posts are not likely to be available for them, we should welcome them and use them.Their numbers may well diminish during the next ten years or so, but they at least give us a chance to adjust to the new situation gradually.If and when these most valuable Common- wealth doctors do stay at home our problem will become more difficult.I don't think the "medical assistant" grade will ever get off the ground, but the "assistant surgeon " with the promise of full status after a limited period-perhaps of only three or four years- may perhaps be more acceptable.Finally, there must be many hospitals where even now the resident strength is well below what has formerly been regarded as desirable, and it would be interesting to hear the views of the consultants involved.-Iam, etc.,
Erratum: Corrigendum: Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling
Authors: Michael P Seiler, Rebecca Mathew, Megan K Liszewski, Chauncey Spooner, Kenneth Barr, Fanyong Meng, Harinder Singh, Albert Bendelac
Journal: Nature Immunology (2013)
When sports and HIV share the bill, smart money goes on common sense
Authors: M. F. Goldsmith
Journal: JAMA (1992)

IT ISN'T GOING to be easy to put all the magic back in basketball, but at least efforts are being made to keep more athletes—on professional, college, and high school teams—from disappearing. In the wake of Earvin (Magic) Johnson's apparent retirement from the Los Angeles (Calif) Lakers after he announced that he was infected with the human immunodeficiency virus (HIV), the National Basketball Association (NBA) has taken the lead among professional US sports organizations in making sure players are fully informed about HIV infection and the acquired immunodeficiency syndrome (AIDS). At the same time, none of the organizations has announced any restrictions on infected team members. Physicians and health educators from The Johns Hopkins School of Hygiene and Public Health, Baltimore, Md, have begun a long-term program of providing disease prevention education and information to everyone on the 27 NBA teams. As new players come into the organization, they will
Relationship Between the Spectral Characteristics of Atrial Fibrillation and Atrial Tachycardias That Occur After Catheter Ablation of Atrial Fibrillation
Authors: Kentaro Yoshida
Journal: Circulation (2008)

Abstract 1136 Kentaro Yoshida, Aman Chugh, Univ of Michigan, Ann Arbor, MI; Magnus Ulfarsson, Univ of Iceland, Reykjavik, Iceland; Eric Good, Krit Jongnarangsin, Frank Pelosi, Frank Bogun, Fred Morady, Hakan Oral, Univ of Michigan, Ann Arbor, MI Kentaro Yoshida, 2008 Finalist and Presenting Author
Activation of Bone Marrow Phagocytes Following Benzene Treatment of Mice
Authors: Debra L. Laskin, Laureen MacEachern, Robert Snyder
Journal: Environmental Health Perspectives (1989)

Techniques in flow cytometry/cell sorting were used to characterize the effects of benzene and its metabolites on subpopulations of bone marrow cells. Treatment of male Balb/c mice with benzene (880 mg/kg) or a combination of its metabolites, hydroquinone and phenol (50 mg/kg), resulted in a 30 to 40% decrease in bone marrow cellularity. Flow cytometric analysis revealed two subpopulations of bone marrow cells that could be distinguished by their size and density or granularity. The larger, more dense subpopulation was found to consist predominantly of macrophages and granulocytes as determined by monoclonal antibody binding and by cell sorting. Benzene treatment had no selective cytotoxic effects on subpopulations of bone marrow cells. To determine if benzene treatment activated bone marrow phagocytes, we quantified production of hydrogen peroxide by these cells using the fluorescent indicator dye, 2',7'-dichlorofluorescein diacetate. We found that macrophages and granulocytes from bone marrow of treated mice produced 50% more hydrogen peroxide in response to the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate than did cells from control animals. It is hypothesized that phagocyte activation and production of cytotoxic reactive oxygen intermediates may contribute to hematotoxicity induced by benzene.
Data Incorrect.
Journal: JAMA (1993)

—In the Original Contribution entitled "Body Fat Distribution and 5-Year Risk of Death in Older Women," published in the January 27, 1993, issue ofThe Journal(1993;269:483-487), incorrect data on waist/hip circumference ratio (WHR) were reported. On page 486, the last sentence of the first paragraph of the "Comment" section should read as follows: "In contrast, WHR was strongly, positively, and monotonically associated with total mortality: for a 0.15-unit [not 0.2-unit] increase in WHR, risk of death increased 1.60-fold [not 1.45-fold], and the women at most risk of death were those with a low BMI [body mass index] and a high WHR."
Screening for Lung Cancer
Authors: Ned Calonge, Janet D. Allan
Journal: Annals of Internal Medicine (2004)

Letters19 October 2004Screening for Lung CancerNed Calonge, MD, MPH and Janet D. Allan, PhD, RN, CSNed Calonge, MD, MPHFrom U.S. Preventive Services Task Force, Rockville, MD 20852.Search for more papers by this author and Janet D. Allan, PhD, RN, CSFrom U.S. Preventive Services Task Force, Rockville, MD 20852.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-8-200410190-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the opportunity to respond to Dr. Petty's letter. It is important to correct his misunderstanding regarding the Task Force recommendation (1). The I letter grade is meant to communicate the lack of sufficient evidence to make a recommendation (either for or against screening); it is distinct from the D letter grade, which is a recommendation against screening.We should screen to detect early-stage lung cancer only if it is shown that, overall, the process of screening—which includes diagnostic work-up and treatment—does more good than harm. The Task Force did not find evidence that this has been ...References1. Lung cancer screening: recommendation statement. Ann Intern Med. 2004;140:738-9. [PMID: 15126258] LinkGoogle Scholar2. Marcus PM, Bergstralh EJ, Fagerstrom RM, Williams DE, Fontana R, Taylor WF, et al . Lung cancer mortality in the Mayo Lung Project: impact of extended follow-up. J Natl Cancer Inst. 2000;92:1308-16. [PMID: 10944552] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From U.S. Preventive Services Task Force, Rockville, MD 20852. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLung Cancer Screening with Sputum Cytologic Examination, Chest Radiography, and Computed Tomography: An Update for the U.S. Preventive Services Task Force Linda L. Humphrey , Steven Teutsch , and Mark Johnson Lung Cancer Screening: Recommendation StatementScreening for Lung Cancer Thomas L. Petty Metrics 19 October 2004Volume 141, Issue 8Page: 650KeywordsCancer screeningCohort studiesComputed axial tomographyDeath ratesLung and intrathoracic tumorsLung cancer screeningMorbidityMortalityProstate cancerThoracotomy ePublished: 19 October 2004 Issue Published: 19 October 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
POSTOPERATIVE NUTRITIONAL EDEMA
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 770: Coordinated Upregulation of Cardiomyocyte Urotensin II (U-II) and its Receptor (UT) Exhibits Enhanced Inhibition of L-Type Calcium Current in Heart Failure
Authors: Heng-Jie Cheng, Qing-Hua Han, Peng Zhou, Atsushi Morimoto, Satoshi Masutani, William C Little, Che-Ping Cheng
Journal: Circulation (2007)

Background . Heart failure has been linked to urotensin II (U-II), the most potent mammalian vasoconstrictor. However, the alteration and functional significance of U-II in HF are uncertain. Methods . We compared LV myocyte U-II and its receptor (UT) protein levels and I Ca,L response to U-II stimulation in 10 normal (N) adult rats and 10 age-matched rats with isoproterenol (ISO)-induced HF (4 months after 340 mg/kg, sq, for 2 days). I Ca,L was measured using whole-cell voltage clamp technique. In 3 subgroups, U-II-mediated actions were determined after pretreatment of myocytes with U-II receptor antagonist, Urantide (10 −5 M); pertussis toxin (PTX, 2μg/ml, 36°C, 6h); and dibutyryl-cAMP (Db-cAMP, 10 −4 M). Results . Compared with normal myocytes, in HF myocytes, both U-II (93%, 0.081 vs 0.042) and UT (52%, 0.038 vs 0.025) protein levels were significantly increased. Importantly, these changes were associated with enhanced U-II -mediated negative modulation on L Ca,L . Superfusion of U-II (10 −8 -10 −5 M) caused a dose-dependent decrease in I Ca,L in both normal and HF myocytes with maximal inhibition at 10 −5 M. In normal myocytes, U-II (10 −5 M) decreased I Ca,L by 18% (5.0±0.29 vs 6.1±0.5 pA/pF, p&lt;0.01). In HF myocytes, the baseline I Ca,L was significantly lower (3.3±0.1 vs 5.9±0.3 pA/pF, p&lt;0.01) and was further reduced by 27% with U-II 10 −5 M (2.4±0.1 vs 3.3±0.1 pA/pF), that was significantly greater than U-II-induced changes in normal myocytes. U-II-induced reductions in I Ca,L were significantly attenuated by U-II-antagonist. In both groups of rats, U-II-induced decreases of I Ca,L were prevented with pretreatment myocytes with PTX (normal: 5.6±0.5 vs 5.5±0.4; HF: 3.4±0.4 vs 3.5±0.2 pA/pF) or Db-cAMP (normal: 5.6±0.5 vs 5.6±0.7; HF: 3.7±0.3 vs 3.8±0.4 pA/pF). Conclusions . In HF rat cardiomyocytes, U-II and UT-coupled, G i -mediated signaling pathway is upregulated, which amplifies U-II stimulation-induced inhibition of I Ca,L . This may lead to exacerbation of the dysfunctional [Ca 2+ ] i homeostasis and enhance cardiac depression of the failing myocardium.
HEMATOLOGY GENERAL
Authors: William R. Best
Journal: JAMA (1966)

<h3>General Texts</h3> Wintrobe's<i>Clinical Hematology</i>(ed 5, Lea &amp; Febiger, 1961, $18.50) has been the bible in many centers; it is authoritative, encyclopedic, and well documented. When information on some obscure aspect of a hematologic problem is desired, chances are that a suitable comment and reference can be found in Wintrobe. The presentation is balanced, with a strong clinical orientation.<i>Laboratory Medicine— Hematology</i>by Miale (ed 2, C. V. Mosby, 1962, $17) is a close competitor, for it also is a scholarly work with an excellent bibliography. Emphasis rests more on laboratory than on clinical aspects. Cellular morphology is more thoroughly covered, as exemplified by 37 interesting, illustrative case presentations. Less encyclopedic but more readily digestible as an introduction is DeGruchy's<i>Clinical Hema-</i><i>tology in Medical Practice</i>(ed 2, F. A. Davis, 1964, $12.50). Descriptions are clear, concise, and accurate, and examination of the blood smear is emphasized. Leavell and
Phase 1 study of combination carboplatin, paclitaxel, and ridaforolimus in patients with solid, endometrial, and ovarian cancers.
Authors: Hye Sook Chon, Patricia Lynn Judson, Sachin Apte, Ji-Hyun Lee, Irene Williams-Elson, Robert Michael Wenham
Journal: Journal of Clinical Oncology (2014)

2614 Background: Ridaforolimus (RIDA) is a mTOR inhibitor that has demonstrated tolerability as intravenous (IV) and oral formulations. PI3K/AKT/mTOR signaling is associated with taxane resistance. In cancer cells, inhibition of mTOR signaling counteracts AKT-mediated resistance to drugs inhibiting tubulin. Paclitaxel and carboplatin (PC) have broad anti-cancer activity, and mTOR inhibition with PC has synergistic and additive effects in solid tumors. This 3+ 3 phase I study was to determine the maximal tolerated dose and R2PD of oral RIDA with PC during the first cycle of treatment. Methods: Solid cancer patients (pts) with measureable disease and <4 prior therapies received P (175mg/m2 IV) and C (AUC 5 to 6 mg/ml/min IV) on day (D)1 of each 3-week (wk) cycle. RIDA in escalating cohorts of 10-40 mg is administered orally daily for 5 days per wk (D1-5, D 8-12, D 15-19) in phase IA cohorts. Samples were collected for pharmacokinetics of RIDA and P and pharmacodynamics. > 1 DLT of thrombocytopenia or neutropenia in latter cycle shifted RIDA to alternate schedule (D1-5, D 8-12). Results: 22 pts have been enrolled; 9 ovarian/fallopian/peritoneal, 5 endometrial, 3 cervical, 2 esophageal, 1 urethral, 1 vaginal, 1 mesothelial. Median age was 63 (ranged 30-72). There were two Grade 4 neutropenias as DLT in dose level 1, thus a switch to predefined alternate dosing schedule (D1-5, D8-12). Dose escalation continued to PC(AUC5) + 40 mg RIDA with 1 of 4 DLTs. Total 166 cycles (ranged 1-12) were administered. Sixteen of 22 pts were evaluable for response: PR (32%), SD (27%), and PD (14%). One non-related to drug death was reported (non-related to drug). Grade 3/4 toxicities were observed in 21 of 22 pts (118 cycles of treatment) and were predominately myelosuppression. Conclusions: Treatment with RIDA combined with PC has no new unanticipated toxicities with activity in pretreated cancers. The RP2D is PC(AUC5) + RIDA 30mg D1-5, D8-10 q 3wk. Clinical trial information: NCT01256268.