tbuckley/cabot-search huggingface dataset:
Royal Free Hospital
Authors: Mr Watts, A Maca, P Allan, Bournemouth Alderson, P Aber Romb E, F Atkinson, Antitoxin Brevet, ; Mr, Chesterton Byrne, Mr Bidwell, R Batten, London Bown, C Campbell, Dublin Cameron, A Corthorn, J Craig, J Cuppaidge, Totnes Cotswold, J Coumbe, Huddersfield Chevers, E Diver, Shotley Bridge, ; Douglas-Crawford, ; Drake, L Drage, Hattleld Deltoid, Mr De La Court, E Deanesly, Wolverhampton Delta, A Tdutt, Oheltenham Duke, Eucaine Eyemes, ; Enquirer, W Freeman, H Ferguson, A Friel, P Freyer, W Ifarquharson, W Fenwict, W Reading, Mr Freyer, Mr Gooch, W Gilbert, Baden Baden, Stoke-On-Trent Gilbert, L Gamble, H Igladstone, P Gardiner, Calcutta Ghosh, J Gooding, Cheltenham Glasg, ; Gono-Coquette;, A Green, R Gibson, Hong Kong, Grange-Over-Sands Gwatkin, G Herman, G Hatton, F Hutchison, S Harris, C Hoar, J Hall, Mr Hosegood, Walsbam North, W Hedley, A Heys
Journal: BMJ (1901)

J. T. W. (Barrow-in-Furness).-The custoIml in rega.rd to permitting smok- ing among patients in the wards varies in different hospitals.In some it is permitted every evening for a limited time even by those confinedto bed, in others, probably in the majority, it is only permitted on special occasions, such as during Christmas festivities.Any objection that could be raised wolld probably have less force in respect of surgical than medical wards.The chief objection under the circumstances mentioned would prnbahly arise from the individual discomfort of any particular patient who disliked smoke or smoking.
Liver
Authors: R Al-Mumfi, E Fhobbs, M Cwinslet
Journal: Gut (1996)

Lipiodol, a poppy seed oil, is take up and retained selectively by primary and some netastatic liver cancers, following injection into the hepatic artery.The mechanism of uptake, retention and cytotoxicty of Lipiodol, constitut and nonstitunt fatty acids by prmary and coloectal hepatic metases tissue cuures was assed usmg growth curves, trypan blue exclusion, LDH assays, 3H-leucine uptake and electrn microsopy.Culurs of Hep-G2 (human hepatoma), LoVo (hepatic colorectal cancer), SW620 (metastatic colorectal cancer) cell lies were studied.The control non-malignant cell lmes used were human hepatocytes, HUVEC (humm
Problems of rectal prolapse.
Journal: BMJ (1970)

Predicting Haemolytic Disease: Ratio of bile pigment to protein in amniotic fluid is a better indication of severity of Rh-haemolytic disease than estimation of bile pigment alone (p. 387).Clonidine in Hypertension: Clonidine had more effect on diastolic pressure than methyldopa in an open, randomized, cross-over study; less acceptable to patients because of side effects (p. 392).Fibrin Degradation Products in Embolism: Serum F.D.P. estimations may prove helpful in diagnosing pulmonary embolism (p.395).Uraemic Acidosis: Sodium acetate found to give comparable results to sodium bicarbonate in correcting uraemic acidosis (p. 399).Spironolactone: An American study shows spironolactone to be a safe and effective diuretic in patients with cirrhosis and ascites (p.401).Fundal Height: Pelvic examination in the first trimester of pregnancy in 233 patients found to be more accurate in assessing gestational age than abdominal palpation at a later time (p. 404).Leader on page 382.Endocrine Function in Homosexuals: Abnormalities shown in a small series of male and female homosexuals (p. 406).
Lengthening Shadows
Authors: John J. Byrne
Journal: New England Journal of Medicine (1981)

TWO hundred years ago the Massachusetts Medical Society was founded by a distinguished group of physicians. It was at the close of the Revolution, and the need for medical organization was so great that the founders overlooked the recent passions and hardships to include Patriots and Tories. The Patriots included John Warren, Thomas Welch, Isaac Rand, and Cotton Tufts, and the Tories included James Lloyd and John Jeffries. The Tories were well educated in London medical schools, and the Patriots were apprentice-trained. Yet they worked together to start the society so sorely needed in the new republic.In 1881, the . . .
DO MATERNAL IMPRESSIONS AFFECT THE FŒTUS IN UTERO?
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New perspectives on inhaled drug delivery and systemic bioactivity
Authors: Serap Hasturk, Yurdanur Erdogan, Ayse Ozyildirim
Journal: Thorax (1995)

mass.After radiotherapy two further cycles of chemotherapy were given.Unfortunately the patient died of neutropenic sepsis in the 10th month of treatment.We believe that combined chemotherapy and radiotherapy can be used in this im- munohistopathologically and clinically rare tumour.
Acute intoxication with methylchloroform
Authors: R. D. Stewart
Journal: JAMA (1966)

Methylchloroform (1,1,1-trichloroethane) is a widely used solvent substitute for carbon tetrachloride. Excessive absorption of methylchloroform through the gastrointestinal tract or lung produces central nervous system (CNS) depression proportional to the amount absorbed. Ingestion is followed by vomiting and diarrhea. Mild liver and kidney dysfunction may occur transiently following recovery from CNS depression. The diagnosis of exposure is established by specifically identifying the solvent in the expired breath. Serial breath analyses allow the estimation of the total amount absorbed. The treatment is supportive to combat the effects of CNS depression. The principles of diagnosis and treatment are illustrated by the case of a man, aged 47, who accidentally ingested one ounce of methylchloroform.
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation
Authors: Attila Braun, David Varga-Szabo, Christoph Kleinschnitz, Irina Pleines, Markus Bender, Madeleine Austinat, Michael Bösl, Guido Stoll, Bernhard Nieswandt
Journal: Blood (2008)
CME Forum
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PROPOSED CRUSADE AGAINST BLINDNESS DUE TO PREVENTABLE OPHTHALMIA NEONATORUM.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2189: Evaluating efficacy of repurposed drugs in treatment of glioblastoma
Authors: Tristan Neal, Nanyun Tang, George Reid, Sara Byron, Harshil Dhruv, Michael Berens
Journal: Cancer Research (2019)

Abstract Glioblastoma (GB) is the most aggressive adult brain tumor with a devastating median survival time of about fourteen months post-surgery and standard of care therapy with radiation and temozolomide. The low incidence of GB is a dis-incentive to develop novel therapies. To overcome that obstacle, we investigated the efficacy of repurposing four FDA approved drugs known to cross the BBB, minocycline, propranolol, chlorpromazine, and metformin, to inhibit signaling and metabolism in GB cells. Minocycline is a tetracycline class broad spectrum antibiotic commonly used to treat severe acne and other skin infections. Propranolol is a beta blocker type heart medication primarily used to treat high blood pressure and irregular heartbeat. Chlorpromazine is a phenothiazine antipsychotic usually used for schizophrenia. Metformin is the most widely used first-line oral treatment for type-2 diabetes. Based on a literature survey, minocycline is expected to prevent the phosphorylation of STAT3, a transcription factor downstream of EGFR; propranolol is expected to disrupt EGFR trafficking; chlorpromazine is expected to target the mTOR/AKT pathway; metformin is believed to exploit vulnerabilities in cancer cell metabolism. Efficacy of minocycline in inhibiting EGFR-driven STAT3 activation was investigated using western blot analysis. Our results demonstrate that Minocycline effectively inhibits activation of EGFR-driven STAT3 in U373 glioma cells at 100μM. The ability of chlorpromazine to inhibit the mTOR/AKT pathway was similarly tested via western blot, which showed inhibition of phosphorylated Akt and S6 at 10μM. Efficacy of propranolol in perturbing EGFR trafficking was evaluated using flow cytometry and immunofluorescence, which depicted altered membrane-associated EGFR abundance. Finally, concentration-dependent inhibition of colony formation was tested for all four drugs. Propranolol and minocycline showed potential stimulatory effects at 10μM, but all drugs inhibited cell growth at 50μM and higher. Efficacy of these drugs in treatment of GB is being further evaluated using in vitro neurosphere cultures from patients identified as having the cellular vulnerabilities potentially targeted by these drugs. Successful completion of this project will lead to in vivo efficacy testing of these four drugs in orthotopic GB PDX models. Citation Format: Tristan Neal, Nanyun Tang, George Reid, Sara Byron, Harshil Dhruv, Michael Berens. Evaluating efficacy of repurposed drugs in treatment of glioblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2189.
THE DIAGNOSIS OF MYOCARDITIS.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What makes a generalist physician?
Authors: R. W. Hale
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The article by Dr Rivo and colleagues<sup>1</sup>contains several basic flaws in the analyses of training components for generalist physician skills. Had the authors contacted the American College of Obstetricians and Gynecologists, the Residency Review Committee, or the American Board of Obstetrics and Gynecology to obtain accurate data, their conclusions most certainly would have been different. Based on review of our educational objectives,<sup>2</sup>obstetrics and gynecology training programs meet 89% of the competencies required. It is of interest, for example, to note that Rivo and colleagues gave a yes to general pediatrics and internal medicine for management of common gynecological problems when in a recent article<sup>3</sup>it was noted that few pediatricians or internists perform these examinations. On the other hand, they gave a no to continuity of care for obstetrics and gynecology because a specific length is not designated in the Residency Review
Eventual central nervous system regeneration?
Authors: P. Cotton
Journal: JAMA (1991)

ADVANCES in central nervous system (CNS) regeneration research may be reminding physicians to never say never. Any attempts at curing paralysis still are a long way off (<i>JAMA</i>. 1981;245: 1201-1206,1293-1301). And much of the current enthusiasm is based on laboratory and animal studies. But "this field is changing, and physicians should not be making drastic statements any more" to paralyzed patients about how medical science will "never be able to do anything to help," says Richard P. Bunge, MD, science director at the University of Miami (Fla) Project to Cure Paralysis. <h3>Goal No Longer 'Outlandish'</h3> There is agreement at the American Paralysis Association, Springfield, NJ. "There is a great deal of optimism that functional return is really not such an outlandish goal anymore," says Margaret Brown, PhD, the association's director of research. Acute treatment with methylprednisolone to limit the extent of damage is now routine therapy for patients who reach
Lymphogranuloma venereum. Outbreak in a university community
Authors: B. A. McLelland
Journal: JAMA (1976)

One aspect of the current epidemic of venereal diseases is the spread of lymphogranuloma venereum (LGV). Formerly confined to the lower echelons of society, it now affects more affluent classes as well. A cluster of four cases was seen in a small college town. Serial LGV complement fixation tests, the most valuable diagnostic tool, may reveal many more cases than reported previously. Early treatment is important. We recommend therapy for all persons sexually exposed to LGV who have any LGV complement fixation test anomaly, whether or not clinical signs develop. (<i>JAMA</i>235:56-57, 1976)
Homburger and Bonner's Medical Care and Rehabilitation of the Aged and Chronically III
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE QUESTION OF CRUELTY IN THERAPEUTIC OBSERVATIONS.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>A Treatise on Mental Diseases, Based upon the Lecture Course of the Johns Hopkins University, 1899, and Designed for the Use of Practitioners and Students of Medicine.</i> By Henry J. Berkley, M. D., Clinical Professor of Psychiatry, the Johns Hopkins University, Chief Visiting Physician to the City Insane Asylum, Baltimore. With Frontispiece, Lithographic Plates, and Illustrations in the Text. (New York, D. Appleton and Company, 1900.)
Journal: American Journal of Psychiatry (1901)
Abstract 3320: Humanized NSG-Tg(Hu-IL15) mice support preclinical immune-oncology efficacy for testing of NK cells based immunology
Authors: Li-Chin Yao, Mingshan Cheng, Danying Cai, Leonard D. Shultz, James G. Keck
Journal: Cancer Research (2020)

Abstract The JAX® Onco-Hu® platform utilizes humanized mice engrafted with tumors to enable in vivo investigation of the interactions between the human immune system and human cancer. A major avenue of our investigation is to generate humanized mouse models containing a more complete human hematopoietic system and robust innate immune cell population. Nature killer (NK) cells are important players of innate defense against cancerous cells by a number of mechanisms, including antibody-dependent cell mediated cytotoxicity (ADCC). To overcome limited NK cell development in humanized NSG™ mice, we have developed NSG-Tg(Hu-IL15) mice constitutively expressing human IL15 in a physiological level. Following CD34+ HSC-engraftment of NSG-Tg(Hu-IL15) mice, significantly higher levels of human NK cells are detectable in peripheral blood as compared to NSG mice and the engraftment is stable for over six months. Levels of circulating human CD45+ cells, CD3+ T cells, and CD33+ myeloid cells are similar between the HSC-engrafted NSG-Tg(Hu-IL15) and NSG mice. Minimal baseline activation of NK cells is detected in the spleen and peripheral blood. Previously we have described that the human NK cells developing in HSC-engrafted NSG-Tg(Hu-IL15) mice are functional and can lyse the NK-sensitive target cells K562 by in vitro cytotoxicity assay. We also showed that NK cells directly limited growth of a PDX melanoma xenograft and NK cell depletion by antibody blockage largely abrogated the delayed PDX growth. Here we extended these observations by evaluating tumor growth of multiple PDX and CDX models in humanized NSG-Tg(Hu-IL15) mice. We found that not all tumors were able to grow and for those that grew some spontaneous regression might still occur. In ex vivo experiments NK cells in the PBMCs isolated from humanized NSG-Tg(Hu-IL15) mice could be activated by Her2+ human cancer cells in the presence of anti-human H2 antibody (Trastuzumab). Furthermore we showed in vivo that humanized NSG-Tg(Hu-IL15) mice mediated efficient ADCC against Daudi B lymphoma cells using anti-human CD20 antibody (Rituximab). Administration of rituximab resulted in significant tumor growth inhibition as measured by both tumor volume and tumor weight. Together these data demonstrate that HSC-engrafted NSG-Tg(Hu-IL15) mice support enhanced development of functional human NK cells and that this mouse model enables preclinical evaluation of NK cell-targeted cancer immunotherapy in vivo. Citation Format: Li-Chin Yao, Mingshan Cheng, Danying Cai, Leonard D. Shultz, James G. Keck. Humanized NSG-Tg(Hu-IL15) mice support preclinical immune-oncology efficacy for testing of NK cells based immunology [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3320.
NIKOLAI IVANOVICH PIROGOFF (1810-1881) RUSSIAN MASTER SURGEON
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal