tbuckley/cabot-search huggingface dataset:
CHOLESTEROL AND THE ANEMIAS
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Consequences of a Fraudulent Scientist on His Innocent Coinvestigators
Authors: R. Wayne Fuqua
Journal: JAMA (1990)

<h3>To the Editor. —</h3> In their recent citation analysis of articles authored or coauthored by Dr Stephen E. Breuning, Garfield and Welljams-Dorof<sup>1</sup>have misled readers by implying that all of these studies are fraudulent. This misrepresentation is evident in several sections of their article. Their quotations from the National Institute of Mental Health (NIMH) Investigative Panel Report<sup>2</sup>that "none of the described studies of psychopharmacologic treatment had been carried out," "only a few of the experimental subjects... were ever studied," and "the complex designs and rigorous methods reported were not employed" erroneously intimate that these statements apply to all of the 20 studies under consideration in their article. In fact, these quotes were drawn from a secondary source<sup>3</sup>that extracted these statements from sections of the NIMH report dealing with three psychopharmacologic treatment studies and with the panel's specific conclusions about Breuning's individual culpability. Other studies that
Activity of the Residual Ovary
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correction
Journal: BMJ (1921)

limbless men themselves shall have a fair and reasonable representation, which shall investigate every phiase of the problem of artificial limb supply.Also, as a further proof of oLr impartiality, it may interest you to know that we, the "moutlhpieces of the dissatisfied," as you term us, are now, at the request of the Ministry of Pensions, putting their standardized light metal model to practical tests.But this impartiality on our side also looks for justice-or is it favour?-toall maker's 'of artificial-li'mbs, wlhether thev beloiDg to the British Asaociatidin of Limb Makers or' not.On this account *e should'expect the impartial commnittee, wlhe set up, to investigate all--that has passed between Messr.3.Desoutter Brothers and the Miinistry of Pensionis (lur inlg
AUSTRALIA
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Rights
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral contraceptive use and the occurrence of pituitary prolactinoma
Authors: K. K. Shy
Journal: JAMA (1983)

To determine whether prior oral contraceptive (OC) use is a risk factor for pituitary prolactinoma, we attempted to identify all women (n=72) with a prolactinoma diagnosed between 1976 and 1980 in three counties in western Washington. A control group of 303 women was selected by dialing random telephone numbers from the same counties. Prior OC use, according to OC indication, was ascertained during a standardized telephone interview. Relative to the risk for women who had never used an OC, the risk of prolactinoma for women who had used OCs for birth control was 1.3 (95% confidence interval, 0.7 to 2.6). This risk was 7.7 for women who used OCs for menstrual regulation (95% confidence interval, 3.7 to 17.0). Previous findings of an association between OC use and prolactinoma may have resulted from OC treatment of menstrual irregularity in women with an undiagnosed prolactinoma. (<i>JAMA</i>1983;249:2204-2207)
Oral Surgery
Authors: Kurt H. Thoma
Journal: New England Journal of Medicine (1949)

Dentoalveolar SurgeryDentoalveolar surgery, which includes the extraction of teeth (exodontia), probably occupies a large part of the time of most oral surgeons.The technic of tooth extraction has been perfected. Teeth judged to be complicated on x-ray examination because of exostosis of the roots or anatomic deformity are excised by an open procedure that allows clear vision and prevents laceration of the soft tissue and fracturing of the surrounding alveolar bone.51 , 52 Much more attention has recently been devoted to the correction of deformities and preparation of the alveolar ridge for the construction of satisfactory dentures.53 , 54 Deformities such as maxillary . . .
A Treatise on Diseases of the Nose and Throat
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lumpectomy plus tamoxifen with or without irradiation in women age 70 or older with early breast cancer.
Authors: K. S. Hughes, L. A. Schnaper, C. Cirrincione, D. A. Berry, B. McCormick, H. B. Muss, B. Shank, C. Hudis, E. P. Winer, B. L. Smith
Journal: Journal of Clinical Oncology (2010)

507 Background: In women 70 years of age or older with early breast cancer undergoing lumpectomy, we had previously shown at a median follow-up (FU) of 7.9 years that tamoxifen alone (Tam) is an effective alternative to tamoxifen plus radiation (TamRT). To provide longer-term results we present outcomes at a median FU of 10.5 years. Methods: Between July 1994 and February 1999, we randomly assigned 636 women 70 years of age or older with clinical stage I, estrogen receptor + (ER+) breast cancer treated by lumpectomy to receive Tam (N = 319) or TamRT (N = 317). Primary endpoints were time to locoregional recurrence, mastectomy for recurrence, distant metastases, and breast cancer-specific and all-cause mortality. Results: The addition of RT to Tam prolonged the time to first recurrence (p = 0.015) due to improved local control by TamRT. Site of first recurrence was local for 9% vs. 2% (Tam vs. TamRT). Specifically, for Tam vs. TamRT, first recurrence occurred in the ipsilateral breast in 8% vs. 2% and solely in the axilla in 1% vs. 0%. The remaining endpoints did not differ by arm (p > 0.05). Comparing the Tam and TamRT arms, respectively, the probability at 10 years of being free from mastectomy was 96% vs. 98% and from distant mets was 95% vs. 93%. Similarly, the 10-year breast-cancer-specific survival was 98% vs. 96%, and overall survival was 63% vs. 61%. Conclusions: At 10.5 years median FU, the data continue to demonstrate that TamRT results in an absolute reduction of 6% in ipsilateral breast tumor recurrence (IBTR) when compared to Tam alone in this population. Otherwise, the addition of radiation does not impact survival, distant disease free survival, breast cancer specific survival or breast conservation. At this time, 43% of women participating in this study have died (but only 7% of those deaths were due to breast cancer). This study demonstrates that with over a decade of follow-up, lumpectomy with antiestrogen therapy, but without the addition of radiation, is an appropriate treatment option for older women with node-negative hormone receptor positive disease. Further, the low rate of breast cancer deaths indicates that breast cancer mortality is not a major concern for this subset of older women. No significant financial relationships to disclose.
Interlude
Authors: Laurence T. Giles
Journal: Annals of Internal Medicine (1998)

Ad Libitum1 April 1998InterludeLaurence T. Giles, MDLaurence T. Giles, MDMadison, WI 53705Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail in groups of meter ... Author, Article, and Disclosure InformationAffiliations: Madison, WI 53705Corresponding Author: Laurence T. Giles, MD, 4714 Fond du Lac Trail, Madison, WI 53705. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 597KeywordsEmotionsHeart rate Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ischemic Duodenitis
Authors: H. Seno, S. Mikami, K. Komatsu, S. Kadota, S. Yazumi, T. Chiba
Journal: Endoscopy (2005)

Ischemic changes in the duodenum have been reported only very occasionally in patients with severe atheromatous disease of the splanchnic arteries [1] [2] [3] [4]. In those cases, the changes were usually chronic and reversed only after revascularization procedures [3] [4]. We present here a rare case of truly ”transient-type” ischemic duodenitis.
Contents
Authors: T Decaens, A Laurent, A Luciani, S Karpen, Ring-Larsen Merkel, Peter Jansen, M Trauner, Scott Friedman, M Pinzani, P Roelandt, S Obeid, J Paeshuyse, J Vanhove, A Lommel, Y Nahmias, F Nevens, J Neyts, C Verfaillie, E Groessl, L Liu, S Ho, F Kanwal, A Gifford, S Asch, S Deuffic-Burban, H Castel, J Wiegand, M Manns, H Wedemeyer, P Mathurin, Y Yazdanpanah, C Fagundes, M.-N Pe ´pin, M Guevara, R Barreto, G Casals, E Sola, G Pereira, E Rodrı ´guez, E Garcia, V Prado, E Poch, W Jime ´nez, J Ferna ´ndez, V Arroyo, P Gine, T Serste, T Gustot, P.-E Rautou, C Francoz, H Njimi, F Durand, D Valla, D Lebrec, R Moreau, G Crespo, G Ferna ´ndez-Varo, Z Mariño, R Miquel, S Martı ´nez, R Gilabert, X Forns, M Navasa, G Germani, E Theocharidou, R Adam, V Karam, J Wendon, J Oõgrady, P Burra, M Senzolo, D Mirza, D Castaing, J Klempnauer, S Pollard, A Paul, J Belghiti, E Tsochatzis, A Burroughs, H Mergental, B.-G Ericzon, P Kalicinski, F Mu ¨hlbacher, K Ho ¨ckerstedt, S Friman, C Broelsch, G Mantion, C Fernandez-Sellez, B Van Hoek, J Fangmann, J Pirenne, P Muiesan, A Ko ¨nigsrainer, J Lerut, O Detry, Y.-P Le Treut, V Mazzaferro, F Lo, M Berenguer, P.-A Clavien, X Rogiers, L Obori, P Wolf, W Schareck, P Pisarski, A Foss, F Filipponi, M Krawczyk, M Wolff, J Langrehr, K Rolles, N Jamieson, W Hop, R Porte, S Faure, A Herrero, B Jung, Y Duny, J.-P Daures, T Mura, E Assenat, M Bismuth, H Bouyabrine, H Donnadieu-Rigole, F Navarro, S Jaber, D Larrey, G.-P Pageaux, J Xu, T Ding, Q He, X.-J Yu, W.-C Wu, W.-H Jia, J.-P Yun, Y Zhang, M Shi, C.-K Shao, W.-D Pan, X.-Y Yin, J Min, S.-M Zhuang, L Zheng, S Wang, W Jiang, X Chen, C Zhang, H Li, W Hou, Z Liu, M Mcnutt, F Lu, G Li, Y Soroida, R Ohkawa, H Nakagawa, Y Satoh, H Yoshida, H Kinoshita, R Tateishi, R Masuzaki, K Enooku, S Shiina, T Sato, S Obi, T Hoshino, R Nagatomo, S Okubo, H Yokota, K Koike, Y Yatomi, H Ikeda, V Puxbaum, E Nimmerfall, C Ba ¨uerl, N Taub, P.-M Blaas, J Wieser, M Mikula, W Mikulits, K Ng, G Yeoh, L Mach, S Pooya, S Blaise, M Moreno, J Giudicelli, J.-M Alberto, R.-M Gue ´ant-Rodriguez, E Jeannesson, N Gueguen, A Bressenot, B Nicolas, Y Malthiery, J.-L Daval, L Peyrin-Biroulet, J.-P Bronowicki, J.-L Gue, L Barbier, S Tay, C Mcguffog, J Triccas, G Mccaughan, D Bowen, P Bertolino, T Lan, A Rao, J Haywood, N Kock, P Dawson, T Folseraas, E Melum, P Rausch, B Juran, E Ellinghaus, A Shiryaev, J Laerdahl, D Ellinghaus, C Schramm, T Weismu ¨ller, D Gotthardt, J Hov, O Clausen, R Weersma, M Janse, K Boberg, E Bjo ¨rnsson, H.-U Marschall, I Cleynen, P Rosenstiel, K Holm, A Teufel, C Rust, C Gieger, H.-E Wichmann, A Bergquist, E Ryu, C Ponsioen, H Runz, M Sterneck, S Vermeire, U Beuers, C Wijmenga, E Schrumpf, K Lazaridis, S Schreiber, J Baines, A Franke, T Karlsen, V Ratziu, J.-F Cadranel, L Serfaty, J Denis, C Renou, P Delassalle, C Bernhardt, G Perlemuter
Journal: Journal of Hepatology (2012)
Follow-up on passive cardiomyoplasty in congestive heart failure: influence of the AcornS cardiac support device on left ventricular function Franz X. Kleber, Steffen Sonntag, Heike Krebs, Katrin Stantke, Wolfgang Konertz. Department of Medicine, Unfallkrankenhaus, Berlin, Germany, Department of Cardiovascular Surgery, Charit�, Berlin, Germany
Journal: Journal of the American College of Cardiology (2001)
Protein C and Protein S
Authors: Margaret E. Rick
Journal: JAMA (1990)

<h3>SELECTED CASE</h3> A 53-YEAR-OLD asymptomatic white man was evaluated for a possible thrombotic tendency after the death of his 19-year-old son from a pulmonary embolus. The father and his relatives had no history of venous thrombotic disease, but there was a history of coronary artery disease in the family. Physical examination of the father was normal. The deceased son had been athletic and was healthy until he sustained a knee injury that required surgery. His postoperative course had been uneventful for 8 weeks after the surgery, when he died suddenly. The postmortem examination revealed a massive pulmonary embolism. Testing performed on a postmortem blood sample was said to show low protein C levels. Laboratory tests showed that the father had a normal complete blood cell count and platelet count and normal results on screening coagulation tests (prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen). Immunologic assays for antithrombin
ED Visits for Strokes Decline While Imaging Rates Increase
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The pathobiology of biliary epithelia
Authors: Gianfranco Alpini, James M. McGill, Nicholas F. LaRusso
Journal: Hepatology (2002)

The morbidity and mortality from chronic biliary diseases ( i.e. , the cholangiopathies) remains substantial. End-stage liver disease from biliary causes of cirrhosis ( e.g. , primary biliary cirrhosis [PBC], and primary sclerosing cholangitis) account for approximately one third of patients referred for liver transplantation. A single-topic conference sponsored by the American Association for the Studies of Liver Diseases entitled “The Pathobiology of Biliary Epithelia” brought together investigators to review the status of the field of cholangiocyte pathobiology, identify new areas of interest, and propose future directions. This information was presented in 6 sessions: “Structural and Functional Characteristics of the Bile Duct System,” “Biological Topics from Nonbiliary Epithelia,” “Malignant Transformation of Cholangiocytes,” “Cholangiocyte Proliferation and Death,” “Transport Mechanisms in Bile Duct Epithelia,” and “Pathobiology of Biliary Epithelia.” In the 7 years since the first symposium on this topic, major advances have been made in our understanding of ductal bile formation, including, greater insight into the hormones, intracellular signaling mechanisms, and effector proteins responsible for bile secretion and absorption. More sophisticated imaging technologies have increased our understanding of the polarity of cholangiocytes, their embryology and ultrastructural anatomy, and in vivo human secretory responses to current medical therapy. Information on mediators of inflammation permeated many sessions, having potentially important roles in malignant transformation of cholangiocytes, cholangiocyte apoptosis, fluid and electrolyte transport, and have begun to be specifically characterized for certain biliary diseases, e.g. , acquired immunodeficiency syndrome (AIDS) cholangiopathy and graft-versus-host disease (GVHD).
Reflections on New Treatments for Burns—Caveat Legor
Authors: Francis D. Moore
Journal: JAMA (1973)

In this issue ofThe Journalappears an article describing with enthusiasm an apparent improvement in the treatment of burns with heparin sodium. The concept is not new, as the authors point out. Burns and cold injury both have a thrombotic element in the perpetuation of tissue damage. The judicious use of an anticoagulant should help in treatment. The hazards of anticoagulants are equally evident because there is also a hemorrhagic element in the tissue damage. This might be made worse by an anticoagulant. Certain complications of burns, such as bleeding gastritis or gastroduodenal ulcer, would certainly be made more hazardous to the patient. The authors have discussed these various aspects and report that the general effect is desirable and helpful to the patient. The hazards of presenting such an article as this, in the general literature, go far beyond these technical or pharmacologic details. They relate, instead, to the
Highlights
Authors: Howard Bauchner, Karl Bilimoria
Journal: JAMA (2016)

Hydrocortisone and Septic Shock in Patients With Severe Sepsis 1775Among patients with severe sepsis and septic shock, adjunctive hydrocortisone treatment may be of benefi t when fl uid resuscitation and vasopressor therapy are inadequate to restore hemodynamic stability.Whether hydrocortisone is effi cacious for patients with severe sepsis without shock is not clear.In a multicenter randomized placebo-controlled clinical trial that enrolled 380 adult patients with severe sepsis without septic shock, Keh and colleagues found that compared with placebo, use of hydrocortisone-200 mg for 5 days followed by dose tapering until day 11-did not reduce the risk of septic shock within 14 days.In an Editorial, Yende and Thompson discuss unresolved questions about the use of corticosteroids in patients with sepsis.