tbuckley/cabot-search huggingface dataset:
Mechanisms of intrathymic tolerance induction to isolated rat hepatocyte allografts
Authors: P Attavar
Journal: Hepatology (1997)

Intrathymic injection of alloantigen in young adult rats is capable of mediating long-lived transplantation tolerance. In this study, we use a well-defined model of isolated hepatocyte transplantation to define the mechanisms of intrathymic induced tolerance. The recipient rats are Nagase analbuminemic rats (NAR) that are deficient in albumin, to allow for following transplant acceptance using metabolic and genetic markers. Tolerance to allogeneic hepatocyte transplants could be mediated by intrathymic injection of live allogeneic splenocytes, lethally irradiated splenocytes, or isolated hepatocytes. Intrathymic injection of live allogeneic splenocytes, but not of hepatocytes or irradiated splenocytes, resulted in donor microchimerism in peripheral lymphoid organs, with preferential expansion of CD4-positive T cells in the recipient spleens. Tolerance could be adoptively transferred from tolerant animals to naive recipients, but only from those animals that had been inoculated with intrathymic donor splenocytes. We conclude that donor microchimerism is found after intrathymic inoculation of live splenocytes, but is not required for tolerance induction and that microchimerism is not an absolute requirement for the generation of regulatory cells.
Deadly Gap
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
StatBite Percent Change in DCIS, Invasive Breast Cancer, and Mammography
Journal: JNCI Journal of the National Cancer Institute (2011)

The rising incidence of DCIS in the United States over the past two decades has been associated with the increase in mammography.Invasive breast cancer has not increased since 1987 and has actually declined since 2000.Whether all women with DCIS should have radiation therapy or other treatment after lumpectomy remains an open question (see study in this issue.)
Haptoglobin phenotypes.
Authors: N G Sitton, J S Dixon
Journal: Annals of the Rheumatic Diseases (1983)

Haptoglobin phenotypes SIR, Haptoglobin (Hp) concentrations in serum are invariably raised in active rheumatoid arthritis (RA) and demonstrate a strong correlation with other measures of disease activity.'Allison and Blumberg reported that the frequency of the common Hp phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2) in 35 patients with RA was not different from that found in 185 normal subjects.2The number of patients involved in the study were small, so we have noted the Hp phenotypes for 177 caucasian patients with active RA (ARA criteria) and 48 patients with ankylosing spondylitis (AS) (New York criteria).The results are compared with previously reported data as shown in Table 1.The normal data from 2 sources are conflicting, making it difficult to assess the results.Despite this discrepancy our results for RA show a closer agreement with the normal distribution than Allison and Blumberg's original series, thus supporting their view that patients with RA do not differ significantly in their Hp phenotype frequency.How- ever, comparing our own data for RA and AS, we find the ratio of Hp 2-1 to Hp 2-2 is approximately 1:1 and 2:1 respectively.The AS group therefore appears to have an altered proportion of Hp 2-1 and Hp 2-2, but a larger sample size may be required to confirm this observation.It
The Anatomy of the Eye and Orbit Including the Central Connections, Development, and Comparative Anatomy of the Visual Apparatus.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic myeloid leukemia
Authors: Susanne Sauβele
Journal: HemaSphere (2018)

Universitätsklinikum Mannheim GmbH, Germany This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CCBY-NC-ND), which allows third parties to download the abstracts and share them with others as long as they credit the author and the abstract book, but they cannot change the content in any way or use them commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
Highlights
Journal: JAMA Psychiatry (2019)

Intranasal Esketamine for Relapse Prevention in Depression 893Esketamine has short-term efficacy for treatment-resistant depression, but its long-term effect is unknown.Daly and colleagues conducted a phase 3 multicenter, double-blind, randomized withdrawal clinical trial of continuation on esketamine nasal spray plus oral antidepressant vs switch to placebo plus oral antidepressant with 455 patients; they found that risk of relapse was significantly reduced in the esketamine arm.These results indicate that esketamine nasal spray has efficacy in reducing risk of relapse among patients with treatmentresistant depression who experienced remission or response.
The British Medical Journal
Journal: BMJ (1886)

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Study on Vitamin 'P.' Part I: Capillary Permeability and Fragility
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Holes in the Jackson Hole approach to health care reform
Authors: T. Rice
Journal: JAMA (1993)

MANAGED competition is synonymous with market-oriented health care reform. Those who coined the phrase, the Jackson Hole Group,<sup>1</sup>have been identified, incorrectly, by the<i>New York Times</i><sup>2</sup>as the brain trust for the Clinton administration's reform proposal. Many medical industry groups have participated in developing the Jackson Hole version of managed competition, including major insurance companies, the American Medical Association, the Pharmaceutical Manufacturers Association, and large health maintenance organizations (HMOs). About the only significant interest groups that have not expressed support for the concept are those representing consumers. In this article, we critically assess the Jackson Hole Group's proposal to control health spending and provide access to quality health care. Boiled down to its fundamentals, the Jackson Hole approach to managed competition requires three major changes in the US health insurance system. First, regional health insurance purchasing cooperatives (HIPCs) are formed to manage the marketplace for health care
Contrast Media May Affect Cardiac Function
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
American Society of Nephrology. 27th annual meeting. October 26-29, 1994. Abstracts.
Journal: Journal of the American Society of Nephrology (1994)

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Medicine: foster mother of the sciences
Authors: W. J. Bell
Journal: JAMA (1966)

Colonel Fielding H. Garrison, in an article published more than 35 years ago, presented a long list of physicians who had made important contributions to the sciences.<sup>1</sup>The botanist Linnaeus, the zoologists Erasmus Darwin and Buffon, the chemist Joseph Black, for examples, were trained as physicians. In America, Louis Agassiz and Asa Gray were medical graduates; Joseph Leidy practiced medicine for a short time and as professor of anatomy in the University of Pennsylvania made basic discoveries in anatomy, paleontology, and parasitology; while the brothers John and Joseph Le Conte and their cousin John Lawrence Le Conte, physiciansall, are remembered for their work in physics, geology, and entomology, respectively. Some years after Garrison's article appeared, Phyllis Allen Richmond, studying the research work of American doctors in the 19th century, concluded that "almost half of the American scientists who made significant research contributions during the nineteenth century were physicians."<sup>2</sup>
Pathology
Authors: E. Tasdemiroglu, M. Kaya, C. H. Yildirim, K. G. Lucas, L. Bao, R. Bruggeman, C. Specht, J. C. Murray, D. J. Donahue, C. A. Galliani, N. A. Blondin, P. Hui, A. Vortmeyer, J. Hasbani, J. Baehring, R. L. Jensen, J. Lee, W. B. Lake, M. K. Baskaya, M. S. Salamat, T. Kennedy, S. Abraham, R. L. Jensen, E. A. Lusis, B. Scheithauer, A. T. Yachnis, M. R. Chicoine, W. Paulus, A. Perry, D. T. Chan, M. K. Kam, B. B. Ma, S. C. Ng, D. Y. Siu, H. K. Ng, W. S. Poon, E. M. Dunbar, H.-J. Dong, C. Liu, Y.-Y. Chi, C. Keeling, A. T. Yachnis, J. H. Stephen, A. J. Sievert, A. C. Resnick, P. B. Storm, A. R. Judkins, M. Santi, M. Kirsch, A. Stelling, E. Koch, R. Salzer, G. Schackert, G. Steiner, B. Pollo, E. Maderna, L. Valletta, S. Guzzetti, M. Eoli, C. Calatozzolo, R. Nunziata, A. Salmaggi, G. Finocchiaro, E. R. Kastenhuber, C. Campos, C. W. Brennan, I. K. Mellinghoff, J. T. Huse, H. Zhang, M. Sergey, D. K. Estrada, A. B. Kay, A. S. Wagner, N. Khanlou, H. V. Vinters, T. F. Cloughesy, W. H. Yong
Journal: Neuro-Oncology (2010)
ABSTRACTS
Journal: Circulation (1958)

The author discusses the pathophysiologic de- rangemients induced by massive pulmonary embo- lism as a background for therapeutic procedures.Among the noxious factors, the most important are acute pulmonary and right ventricular hyper- tension, interference with capillary-alveolar gas exchange, reduction of pulmonary venous and left ventricular filling, peripheral vascular collapse and visceral hypoxia.Among secondary factors, the local liberation of serotonin is considered as pos- sibly leading to further vasomotor reactions.Ther- apeutically, the use of vasopressor amines, partic- ularly norepinephrine and Aramin is recommended.Anticoagulants are advised for prophylaxis.Sur- gical procedures such as embolectomy and vein ligation have only limited value but are occasion- ally life saving.PICK
PNEUMONIA MORTALITY AND PROPHYLAXIS.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiothoracic Surgery
Authors: John W. Hammon
Journal: JAMA (1986)

Much progress has been made in the treatment of cardiovascular diseases in the last decade. However, heart disease remains the principal cause of death in the United States (328 persons per 100 000 annually). A continued and rapid evolution in the treatment of patients with ischemic heart disease has affected the practice of cardiothoracic surgery substantially. It is estimated that 85 000 percutaneous transluminal coronary angioplasty (PTCA) procedures were performed in this country in 1984 and a greater number in 1985. Whereas, in the initial stages of the development of this procedure, single-vessel disease was the most common indication, it is now being performed in some centers on patients with double- and triple-vessel disease. The impact of PTCA on the numbers of patients being referred for coronary bypass operations is becoming noticeable, and the role of the surgeon in the treatment of these patients is not yet clear. There is
Systematic review of endoscopic mucosal resection versus transanal endoscopic microsurgery for large rectal adenomas
Authors: R. Barendse, F. van den Broek, E. Dekker, W. Bemelman, E. de Graaf, P. Fockens, J. Reitsma
Journal: Endoscopy (2011)

Barendse RM et al. Systematic review of endoscopic mucosal resection versus transanal endoscopic microsurgery for large rectal adenomas. Endoscopy 2011; 43: published online 04. 10. 2011
Medical Unintelligence
Authors: STEWART W. SHANKEL
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 March 1982Medical UnintelligenceSTEWART W. SHANKEL, M.D.STEWART W. SHANKEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-384_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently while reading an article on cytotoxic autoantibodies to beta cells in the serum of patients with insulin-dependent diabetes mellitus (1), I found myself spending an inordinate amount of time trying to remember the meaning of the numerous abbreviations that increased with each succeeding paragraph. Being unable to remember many of these abbreviations, I was forced to either refer back to the earlier part of the text for their meaning or else read the article, missing the meaning of many abbreviations and ending up with almost no understanding of what the authors were trying to convey.As...Reference1. DOBERSENSCHARFFGINSBERG-FELLNERNOTHINS MJFA. Cytotoxic autoantibodies to beta cells in the serum of patients with insulin-dependent diabetes mellitus. N Engl J Med. 1980;303:1493-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Nevada Reno, NV 89520 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1982Volume 96, Issue 3Page: 384-384KeywordsAutoantibodiesCellsDiabetes mellitusInsulin Issue Published: 1 March 1982 PDF DownloadLoading ...
Correction
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delinquent Children
Authors: R. G. Gordon
Journal: BMJ (1949)

any form of sexual relation, even platonic.He knows that this is counsel of perfection, and thinks that legal penalties should attach only to actions corresponding to those for which normal men are punished.The frequency of inversion has probably been exaggerated through failure to distinguish it from bisexuality, and the author estimates that the percentage of inverts in the male population is not more than five.This figure may seem high, but lower estimates may be due to lack of skill on the observer's part.The author found no evidence for the opinion that seduction plays a significant part in causing inversion-an opinion reminiscent of the attribution of tumours to trauma.Of his more r'ecent findings, perhaps the most interesting is -that sexual attraction between inverts is extremely rare: a male invert almost invariably desires that his "mate" shall be a com- pletely normal man.The conclusion drawn is that " all psychosexual attraction is essentially heterosexual."The book leaves no doubt that sexual inversion is wholly involuntary or that most inverts-like most normal men-try to live decent and useful lives.This work will be helpful to specialists, whose knowledge of inversion may be based solely on clinical experience.To general practitioners-and indeed to all who have to deal with young people-it will be invaluable.
Cardiovascular Diseases
Authors: Marvin I. Dunn
Journal: JAMA (1984)

Coronary heart disease is the major cause of death in industrialized societies. Annually, it is responsible for over 1 million myocardial infarctions and 500,000 deaths in the United States. It is estimated that, in the United States, the total expenditure for treatment and disability compensation from coronary heart disease is more than $60 billion a year. Angina pectoris and myocardial infarction are the primary clinical manifestations of coronary heart disease. The clinical spectrum of angina pectoris was described by William Herberden in 1772, and the clinical findings of acute myocardial infarction were described by J. B. Herrick in 1912. Since then, considerable progress has occurred in improving the management and prognosis of coronary heart disease. In the past two years, monumental achievements have been made. The introduction of the coronary care unit independently by Meltzer and Day was the first major change in the modern management of acute myocardial infarction.