tbuckley/cabot-search huggingface dataset:
Counterpoint: estrogen effects on calcitropic hormones and calcium homeostasis
Authors: R. L. Prince
Journal: Endocrine Reviews (1994)

Journal Article Counterpoint: Estrogen Effects on Calcitropic Hormones and Calcium Homeostasis Get access Richard Lewis Prince Richard Lewis Prince 1Department of Medicine, The University of Western Australia Nedlands, Western Australia 6009 *Address requests for reprints to: Richard L. Prince, M.D., FRACP, University Department of Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia. Search for other works by this author on: Oxford Academic Google Scholar Endocrine Reviews, Volume 15, Issue 3, 1 June 1994, Pages 301–309, https://doi.org/10.1210/edrv-15-3-301 Published: 01 June 1994
p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability
Authors: Andrew P. Feranchak, Tomas Berl, Juan Capasso, Paul A. Wojtaszek, Jiahuai Han, J. Gregory Fitz
Journal: Journal of Clinical Investigation (2001)

In hepatocytes, Na+ influx through nonselective cation (NSC) channels represents a key point for regulation of cell volume. Under basal conditions, channels are closed, but both physiologic and pathologic stimuli lead to a large increase in Na+ and water influx. Since osmotic stimuli also activate mitogen-activated protein (MAP) kinase pathways, we have examined regulation of Na+ permeability and cell volume by MAP kinases in an HTC liver cell model. Under isotonic conditions, there was constitutive activity of p38 MAP kinase that was selectively inhibited by SB203580. Decreases in cell volume caused by hypertonic exposure had no effect on p38, but increases in cell volume caused by hypotonic exposure increased p38 activity tenfold. Na+ currents were small when cells were in isotonic media but could be increased by inhibiting constitutive p38 MAP kinase, thereby increasing cell volume. To evaluate the potential inhibitory role of p38 more directly, cells were dialyzed with recombinant p38α and its upstream activator, MEK-6, which substantially inhibited volume-sensitive currents. These findings indicate that constitutive p38 activity contributes to the low Na+ permeability necessary for maintenance of cell volume, and that recombinant p38 negatively modulates the set point for volume-sensitive channel opening. Thus, functional interactions between p38 MAP kinase and ion channels may represent an important target for modifying volume-sensitive liver functions.
Oxidant Gases
Authors: Michael J. Evans
Journal: Environmental Health Perspectives (1984)

The acute and chronic action of the oxidant gases ozone, nitrogen dioxide and oxygen on the morphological appearance of cells of the alveolar and bronchiolar epithelium is reviewed. Type I cells of the alveolar and ciliated cells of the bronchiolar epithelium appear to be sensitive targets for the oxidant gases. The degree of damage is influenced by age, nutritional status and the development of tolerance.
<i>QuickStats:</i>Gestational Weight Gain* Among Women with Full-Term, Singleton Births, Compared with Recommendations — 48 States and the District of Columbia, 2015
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Gestational weight gain was within the recommended range for 32% of women giving birth to full-term, singleton infants in 2015, with 48% gaining more weight and 21% less weight than recommended. Approximately 44% of women who were underweight before pregnancy gained within the recommendations, compared with 39% of women who were normal weight, 26% of women who were overweight, and 24% of women with obesity before pregnancy. Weight gain above the recommendations was highest among women who were overweight (61%) or had obesity (55%) before pregnancy.
Abstract 15837: Circulating Proneurotensin Concentrations Predict Cardiovascular Disease Events in the Community: The Framingham Heart Study
Authors: James Januzzi, Asya Lyass, Yuyin Liu, Hanna K Gaggin, April Trebnick, Ralph B D'Agostino, Thomas J Wang, Joseph Massaro, Vasan Ramachandran
Journal: Circulation (2015)

Introduction: Neurotensin is a 13-amino acid peptide whose receptor (SORT1) is strongly linked to cardiovascular disease (CVD) development through several mechanisms, including a role in hepatic low density lipoprotein (LDL) metabolism. We measured concentrations of proneurotensin (PNT; the stable pro-fragment of neurotensin) in subjects from the Framingham Heart Study (FHS) Offspring cohort. Hypothesis: Concentrations of PNT provide incremental information for incident CV events, possibly through interactions with LDL. Methods: Blood samples from 3439 fasting subjects (mean age 59.2 years, 47.1% male) were tested for PNT (Sphingotec, Hennigsdorf, GE). The primary outcome of interest was incident hard CVD (composite of myocardial infarction [MI], stroke, and CV death). Incident hard CHD (MI and CV death) was also examined. Results: Compared to subjects in PNT quartiles 1-3, those in the highest quartile were more likely to be younger and heavier, more likely to smoke (all P &lt;0.007), and across PNT quartiles more likely to have prevalent CVD (from 24.4% to 31.1%; P =0.003) and diabetes mellitus (from 5.5% to 13.4%; P&lt;0.001). No association between PNT and LDL concentrations was observed. In age and sex-adjusted Cox proportional hazards models, log-PNT concentrations predicted incident hard CVD (hazard ratio [HR] = 1.24 per one standard deviation [SD] change in log-PNT; 95% confidence intervals [CI] = 1.11-1.39; P &lt;0.001). Greatest risk for incident hard CVD was observed in log-PNT quartile 4 (HR = 1.53 per one SD change in log-PNT vs quartile 1; P =0.005). In models adjusted for standard risk factors, log-PNT remained significantly associated with incident hard CVD (HR = 1.13 per one SD change in log-PNT; 95% CI = 1.01-1.27; P = 0.03). Addition of log-PNT to the FHS Risk Score resulted in modest risk reclassification (NRI = 0.024; 95% CI=-0.0008-0.048), and in Kaplan Meier analyses, shorter time to first event was seen in higher log-PNT values (log rank P = 0.02). Similar results were found for hard CHD. We did not observe effect modification by LDL. Conclusions: Higher concentrations of PNT are associated with a greater risk of incident hard CVD and CHD in the community independent of LDL concentrations and other risk factors.
Methylene Blue in Grave Malaria Cachexia.
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB1352 Survey of off-label anti-IL1 treatments in france: One-year results
Authors: L. Rossi-Semerano, B. Fautrel, C. Galeotti, D. Wendling, E. Hachulla, G. Grateau, M. Fouillet-Desjonquères, O. Richer, I. Touitou, I. Kone-Paut
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Despite their limited licensed indications, anti-IL1 agents are often used in real-life practice for an increasing number of diseases. A national survey to record their off-label use in France was started in January 2011. The survey is coordinated by the French National Reference Centre for Auto-inflammatory Diseases, under the aegis of the “Club Rhumatisme et Inflammation” (CRI). <h3>Objectives</h3> The survey aims to gather information concerning: the number of patients treated with anti-IL1 agents in France, the treated disease, the kind and the indication of the used anti-IL1 agents, their efficacy and safety <h3>Methods</h3> We set up a physician-directed questionnaire available on the CRI website since January 2011, covering the following areas: patient data, disease data, anti-IL1 agent, its efficacy, adverse events (AE). We advertised the study on the occasion of French and European rheumatology congresses and by e-mail to French physicians who were willing to participate. Any adult or paediatric patient who had received an anti-IL1 agent since January 2005 in France could be included after medical informed consent. <h3>Results</h3> At present 143 patients (101 adults, 42 children), from 27 centres have been included. Main diseases were: systemic onset juvenile idiopathic arthritis (SoJIA) (22), adult onset Still’s disease (AoSD) (21), cryopirin associated periodic syndrome (CAPS) (20), gout (13), mevalonate kinase deficiency (MKD) (12), SAPHO (9), familial Mediterranean fever (FMF) (9), and Schnitzler’s syndrome (7). The main off-label used agent was anakinra, used at least once in 139 patients. Canakinumab was used in 21 patients. Rilonacept is not yet available in France. Anakinra, showed partial to complete efficacy in most patients; complete clinical response rates varied according to specific diseases, being higher in gout, CAPS, AoSD and Schnitlzler’s syndrome. The majority of patients showed at least one AE, mainly minor injection site reactions,and some showed a serious AE (SAE), mainly severe infection. Preliminary data of our survey suggest that canakinumab was generally well tolerated, without any SAE <h3>Conclusions</h3> One-year results of the survey confirm the wide use of anti-IL1 agents in clinical practice. The survey definite results might justify controlled clinical trials leading to widen the licensed indications for this class of therapeutics <h3>Disclosure of Interest</h3> L. Rossi-Semerano Grant/Research support from: Swedish Orphan Biovitrum, B. Fautrel: None Declared, C. Galeotti: None Declared, D. Wendling: None Declared, E. Hachulla Consultant for: Swedish Orphan Biovitrum, Novartis, G. Grateau Consultant for: Novartis, M. Fouillet-Desjonquères: None Declared, O. Richer: None Declared, I. Touitou: None Declared, I. Kone-Paut Grant/Research support from: Swedish Orphan Biovitrum, Consultant for: Novartis
Additional Author Affiliation
Journal: JAMA (2016)

Dean J. Kereiakes, MD; Robert W. Yeh, MD; Joseph M. Massaro, PhD; Priscilla Driscoll-Shempp, MBA; Donald E. Cutlip, MD; P. Gabriel Steg, MD; Anthony H. Gershlick, MD; Harald Darius, MD; Ian T. Meredith, MD, PhD; John Ormiston, MD; Jean Francois Tanguay, MD; Stephan Windecker, MD; Kirk N. Garratt, MD; David E. Kandzari, MD; David P. Lee, MD; Daniel I. Simon, MD; Adrian Corneliu Iancu, MD; Jaroslaw Trebacz, MD, PhD; Laura Mauri, MD; for the Dual Antiplatelet Therapy (DAPT) Study Investigators
Computers Aid New Look In Postoperative Care
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
Authors: Douglas M. Heuman, Souheil G. Abou-Assi, Adil Habib, Leslie M. Williams, Todd R. Stravitz, Arun J. Sanyal, Robert A. Fisher, Anastasios A. Mihas
Journal: Hepatology (2004)

Despite the adoption of “sickest first” liver transplantation, pretransplant death remains common, and many early deaths occur despite initially low Model for End-stage Liver Disease (MELD) scores. From 1997-2003, we studied 507 cirrhotic United States veterans referred for consideration of liver transplantation to identify additional predictors of early mortality. Most of the patients were male (98%) with cirrhosis caused by hepatitis C and/or alcohol (88%). Data for 296 patients referred prior to February 27, 2002 (training group), were analyzed; findings were validated in 211 patients referred subsequently (validation group). In the training group, 61 patients (21%) died within 180 days without transplantation; their median initial MELD score was 21. MELD score, persistent ascites, and low serum sodium (&lt; 135 meq/L) were independent predictors of early mortality. In patients with a MELD score of less than 21, only low serum sodium and persistent ascites were independent predictors of mortality; for MELD scores above 21, only MELD was independently predictive. Prognostic significance of persistent ascites and low serum sodium for low MELD score patients was confirmed in the validation group. Risk varied continuously with worsening hyponatremia. Modifying MELD, by including points for persistent ascites and low serum sodium, improved prediction of early pretransplant mortality in low MELD score patients. In conclusion, persistent ascites and low serum sodium identify patients with cirrhosis with high mortality risk despite low MELD scores. Ascites, hyponatremia, and other findings indicative of hemodynamic decompensation merit further prospective study as prognostic indicators in patients awaiting liver transplantation, and should be considered in setting minimal listing criteria. Supplementary material for this article can be found on the Hepatology website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html). (Hepatology 2004;40:802-810).
Heartburn
Authors: Bernard S. Wolf
Journal: JAMA (1976)

There is currently controversy as to the importance of the radiologic demonstration of a hiatal hernia, reflux, or both as the explanation of heartburn. It is clear, however, that clinical-radiologic correlation requires additional observations such as the straightness of the potential path for reflux, the presence of a contractile esophagogastric region, the degree of extrinsic compression of the cuff of the stomach within the hiatus, the size of the hernia, and the peristaltic activity of the body of the esophagus. Vigorous or water-swallowing maneuvers to demonstrate reflux are unreliable in individual cases. Of importance is the concept that the so-called patulous cardia, or effaced abdominal esophagus or widened or absent "submerged segment," is a variety of sliding hiatal hernia that is often neglected radiologically but may be of considerable clinical significance. (<i>JAMA</i>235:1244-1247, 1976)
A study of physical light screening agents
Authors: T.M. MACLEOD, W. FRAIN-BELL
Journal: British Journal of Dermatology (1975)

Journal Article A study of physical light screening agents Get access T.M. MACLEOD, T.M. MACLEOD Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar W. FRAIN‐BELL W. FRAIN‐BELL Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 92, Issue 2, 1 February 1975, Pages 149–156, https://doi.org/10.1111/j.1365-2133.1975.tb03051.x Published: 01 February 1975 Article history Accepted: 25 May 1974 Published: 01 February 1975
THE COMMITMENT OF THE INSANE.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum
Authors: J. E. Garber
Journal: JNCI Journal of the National Cancer Institute (1989)

Dr. J. E. Garber regrets to inform the readers of an error in her report (J Natl Cancer Inst 1988;80:1626–1628). In the third paragraph under the Comments subheading on page 1627, the second sentence should read: The observed total of six cases of both hepatoblastoma and polyposis from Western Europe and North America exceeds the 0.01 persons expected to have both conditions annually.
On Diseases of Joints
Authors: H. Coote
Journal: BMJ (1858)

structure, anid no tubercles were found in them, but the right lung was complr-essed.A copious deposit of tubercle was found in the lbronchiall glands.The heart was healthy.The liver was stndded with masses of crude tubercle, and the glands in its neiblibonrhood, were also affected.R~lIAnKS.The above cases are quoted as somewhat rare
Mislabeled Curves in a Figure
Authors: Gretchen Bandoli, Rebecca Baer, Dawn Gano, Laura Pawlowski, Christina Chambers, Gano Baer
Journal: JAMA Neurology (2020)

Salomeh Keyhani, MD, MPH; Eric M. Cheng, MD; Katherine J. Hoggatt, PhD; Peter C. Austin, PhD; Erin Madden, MPH; Paul L. Hebert, PhD; Ethan A. Halm, MD, MPH, MBA; Ayman Naseri, MD; Jason M. Johanning, MD; Danielle Mowery, PhD; Wendy W. Chapman, PhD; Dawn M. Bravata, MD
NAPKIN PSORIASIS*
Authors: R. P. WARIN, K. E. FAULKNER
Journal: British Journal of Dermatology (1961)

Journal Article NAPKIN PSORIASIS Get access R. P. WARIN, M.D., F.R.C.P., R. P. WARIN, M.D., F.R.C.P. The United Bristol Hospitals Search for other works by this author on: Oxford Academic Google Scholar K. E. FAULKNER, M.B., Ch. B., D.P.H., D.C.H. K. E. FAULKNER, M.B., Ch. B., D.P.H., D.C.H. The United Bristol Hospitals Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 73, Issue 12, 1 December 1961, Pages 445–447, https://doi.org/10.1111/j.1365-2133.1961.tb14997.x Published: 01 December 1961
REPRINT COURTESY
Authors: Richard Kovacs
Journal: JAMA (1942)

<h3>To the Editor:—</h3> Authors of scientific articles take pride in sending reprints to their medical friends and to libraries; they are also pleased to receive letters of comment with a request for a reprint. But they all tire sooner or later of responding to the free reprint collector who sends a form postcard with his name stamped on or who scribbles his request on a penny postcard. Authors spend many weary hours writing their article and getting it into print; they have to pay for the reprints, envelops and stamps unless they are sagacious enough to carry on under the auspices of some foundation. So it would seem elementary courtesy on the part of a medical man in quest of a reprint to write on his own stationery and to enclose a return postage stamp. Only a few physicians do this. Under the increasing economic duress, most authors in the
Dumping
Authors: Howard T. Jessamy
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The March 20, 1987, issue of<i>JAMA</i>included an article entitled "Patient Dumping" by Drs Ansell and Schiff.<sup>1</sup>The article is of major concern to the District of Columbia Hospital Association and its members because it refers briefly to Washington, DC, as having an increase in patient dumping, without providing any supporting evidence. Simply stated, the statistics as reported by Drs Ansell and Schiff are accurate;<i>transfers</i>from private hospitals in the District of Columbia did increase by the numbers indicated. They, however, called these transfers dumping, and therein lies their error. The authors define dumping as "the denial of or limitation in the provision of medical services to a patient for economic reasons and the referral of that patient elsewhere." This definition may hold for the examples they cite from Chicago and Dallas, but it is not appropriate for the District of Columbia. It seems
ESGE Newsletter
Journal: Endoscopy (2015)

Globally there is an ever increasing amount of GI endoscopy research being conducted with the aim of expanding our understanding of disease, diagnosis and the role of technological advances. High numbers of studies taking place simultaneously, often with overlapping research areas, can make it difficult to gain a clear perspective on the most pressing, but as yet unaddressed research questions. Knowledge gaps can develop and without a coordinated approach they can be challenging to identify and prioritize. The ESGE should play a key role in leading and guiding endoscopy research and in advising those providing resources as to the most important areas to prioritise.
Pathogenic Microörganisms. A Practical Manual for Students, Physicians and Health Officers.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal