tbuckley/cabot-search huggingface dataset:
Second- or third-line nivolumab (Nivo) versus nivo plus ipilimumab (Ipi) in malignant pleural mesothelioma (MPM) patients: Results of the IFCT-1501 MAPS2 randomized phase II trial.
Authors: Arnaud Scherpereel, Julien Mazieres, Laurent Greillier, Pascal Dô, Olivier Bylicki, Isabelle Monnet, Romain Corre, Clarisse Audigier-Valette, Myriam Locatelli-Sanchez, Olivier Molinier, Luc Thiberville, Thierry Urban, Catherine Ligeza-poisson, David Planchard, Elodie Amour, Franck Morin, Denis Moro-Sibilot, Gerard Zalcman
Journal: Journal of Clinical Oncology (2017)

LBA8507 The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Monday, June 5, 2017, and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Monday edition of ASCO Daily News.
Electrocardiographic QRS axis shift as a manifestation of hyperkalemia
Authors: G. A. Ewy
Journal: JAMA (1971)

Four patients had deviation of the mean QRS axis as an electrocardiographic manifestation of hyperkalemia. Two patients had a leftward and superior axis shift and two had a rightward and inferior axis shift. These findings are reported so that the spectrum of electrocardiographic changes associated with hyperkalemia will be appreciated.
Cancer cachexia is regulated by selective targeting of skeletal muscle gene products
Authors: Swarnali Acharyya, Katherine J. Ladner, Lori L. Nelsen, Jeffrey Damrauer, Peter J. Reiser, Steven Swoap, Denis C. Guttridge
Journal: Journal of Clinical Investigation (2004)

Cachexia is a syndrome characterized by wasting of skeletal muscle and contributes to nearly one-third of all cancer deaths. Cytokines and tumor factors mediate wasting by suppressing muscle gene products, but exactly which products are targeted by these cachectic factors is not well understood. Because of their functional relevance to muscle architecture, such targets are presumed to represent myofibrillar proteins, but whether these proteins are regulated in a general or a selective manner is also unclear. Here we demonstrate, using in vitro and in vivo models of muscle wasting, that cachectic factors are remarkably selective in targeting myosin heavy chain. In myotubes and mouse muscles, TNF-α plus IFN-γ strongly reduced myosin expression through an RNA-dependent mechanism. Likewise, colon-26 tumors in mice caused the selective reduction of this myofibrillar protein, and this reduction correlated with wasting. Under these conditions, however, loss of myosin was associated with the ubiquitin-dependent proteasome pathway, which suggests that mechanisms used to regulate the expression of muscle proteins may be cachectic factor specific. These results shed new light on cancer cachexia by revealing that wasting does not result from a general downregulation of muscle proteins but rather is highly selective as to which proteins are targeted during the wasting state.
Prevention of contast media-associated nephrotoxicity: Randomized comparison of two hydration regimens in 1620 patients undergoing elective or emergency PTCA Christian M�ller, Gerd B�rkle, Heinz J. B�tner, Andre P. Perruchoud, Helmut Roskamm. Medizinische Universit�tsklinik, Basel, Switzerland, Herz-Zentrum, Bad Krozingen, Germany
Journal: Journal of the American College of Cardiology (2001)
Fallot's Tetralogy: Postoperative Study
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Publications.
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mice Lacking the Neuropeptide α-Calcitonin Gene-Related Peptide Are Protected Against Diet-Induced Obesity
Authors: Christopher S. Walker, Xiaoling Li, Lynda Whiting, Sarah Glyn-Jones, Shaoping Zhang, Anthony J. Hickey, Mary A. Sewell, Katya Ruggiero, Anthony R. J. Phillips, Edward W. Kraegen, Debbie L. Hay, Garth J. S. Cooper, Kerry M. Loomes
Journal: Endocrine Reviews (2010)
THE SIGNIFICANCE OF HUMAN ATYPICAL ISOAGGLUTININS
Authors: P. W. C.
Journal: Annals of Internal Medicine (1941)

Editorial1 November 1941THE SIGNIFICANCE OF HUMAN ATYPICAL ISOAGGLUTININSP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-5-927 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe discovery of the human blood groups and their routine determination in the selection of donors for transfusion removed the major peril of this procedure by eliminating most of the serious hemolytic reactions which followed the administration of incompatible blood. In spite of this precaution, however, an occasional reaction of this type has continued to occur. In a large majority of the cases reported in the earlier literature, it could be shown that errors in group determination had been made, and that the blood given had really been incompatible. Improvements in technic and adequate care in performing the tests can...1 WIENERPETERS ASHR: Hemolytic reactions following transfusions of blood of the homologous group, with three cases in which the same agglutinogen was responsible, ANN. INT. MED., 1940, xiii, 2306-2322. Google Scholar2 LANDSTEINERWIENER KAS: An agglutinable factor in human blood recognized by immune sera for rhesus blood, Proc. Soc. Exper. Biol. and Med., 1940, xliii, 223. CrossrefGoogle Scholar3 LANDSTEINERWIENER KAS: Studies on an agglutinin (Rh) in human blood reacting with anti-rhesus sera and with human isoantibodies, Jr. Exper. Med., 1941, lxxvi, 309-319. CrossrefGoogle Scholar4 LEVINEPOLAYES PSH: An atypical hemolysin in pregnancy, ANN. INT. MED., 1941, xiv, 1903-1908. Google Scholar5 LEVINEKATZINBURNHAM PEML: Immunization in pregnancy. Its possible bearing on the etiology of erythroblastosis fetalis, Jr. Am. Med. Assoc., 1941, cxvi, 825827. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1941Volume 15, Issue 5Page: 927-930KeywordsBloodBlood banksBlood groupsBlood transfusion ePublished: 1 December 2008 Issue Published: 1 November 1941 PDF downloadLoading ...
A Phase Ib Study of IMU-131 HER2/neu peptide vaccine plus chemotherapy in patients with HER2/neu overexpressing metastatic or advanced adenocarcinoma of the stomach or gastroesophageal junction
Authors: Y. Chao, M. Maglakelidze, L.V. Bulat, T. Yau, S. Tanasanvimon, C. Charoentum, W. Arpornwirat, J. Maneechavakajorn, A. Dechaphunkul, T. Ungtrakul, C.-J. Yen, L.-Y. Bai, W.-C. Chou, U. Weidermann, E. Garner-Spitzer, N. Ede, L. Chong, A. Good
Journal: Annals of Oncology (2019)
THE DALLAS SESSION
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proliferation and Differentiation Biomarkers in Colorectal Mucosa and Their Application to Chemoprevention Studies
Authors: Alessandra Scalmati, Martin Lipkin
Journal: Environmental Health Perspectives (1993)

Colorectal cancer is one of the leading causes of morbidity and mortality in Western countries. Because its prognosis is relatively unaffected by improvements in surgery and chemotherapy, increasing interest has recently been directed toward chemoprevention. Intermediate biomarkers of abnormal cell proliferation, differentiation, and gene expression have recently been identified and have served to measure effects of chemopreventive agents in rodent models and in short-term human clinical trials. Alterations in cell proliferation and differentiation have been found in preneoplastic diseases and in normal-appearing colorectal mucosa of patients at increased risk for malignancy. Several techniques are available for measuring these alterations, and standardization and comparison of different methods are underway to assess the utility of various intermediate biomarkers in chemoprevention studies.
Book Review Thérapeutique Médicale. I. Maladies du Tube Digestif . Par Maurice Loeper, Professeur de Thérapeutique a la Faculté de Médecine de Paris, Médecin de l'Hôpital de la Pitié. Avec la collaboration du Dr. Andre Lemaire, Chef de Laboratoire a la Faculté. Masson et Cie, Libraires de L'Académie de Médecine. Paris. 372 pages illustrated. 50 fr.
Journal: New England Journal of Medicine (1930)
Oral Surg, Oral Med, and Oral Path, St. Louis
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nitroprusside revisited.
Authors: J Wilson, C J Vesey, P V Cole
Journal: BMJ (1971)

boy of average height during a current survey; the fact remains that this boy was of average height at the time of our survey.Had we concentrated on boys of above average height (as is often the case in studies involving XYY individuals), this boy would not have been spotted.(2) As our survey is still in progress we deliberately did not extrapolate his height for two reasons: (a) the boy is still under observation and we are hoping to be able to follow his growth as long as possible; (b) we supplied the two measurements in our paper to enable interested readers to do their own extrapolating.-Weare, etc.,
"How to Write a Medical Article—A Plea for Plagiarism."
Authors: G. F. Lydston
Journal: JAMA (1903)

Chicago, Dec. 4, 1903. Dr. W. E. Fitch: <h3>Dear Sir:</h3> —I shall take great pleasure in publishing your letter and the attached affidavit. I will state that my critique was based, not only on the article in the<i>Annals of Pediatry and Gynecology</i>, but on a reprint<i>received from you</i>by one of my friends. I would suggest in passing that it is hardly fair to the profession for one to publish as original articles copied verbatim from text-books by an amanuensis. I would further remark that, in justice to yourself, you ought at least to look over the proofs of your articles or read them after they are printed and before sending out your reprints. I assure you, my dear sir, I do not feel that the matter under consideration was so much a grievance to myself as a violation of a principle in which we are all interested.
<i>Nervous and Mental Diseases</i>. By Archibald Church, M. D., Professor of Nervous and Mental Diseases in Northwestern University Medical School, Chicago; and Frederick Peterson, M. D., formerly Professor of Psychiatry, Columbia University. Eighth edition, revised. (<i>Philadelphia and London: W. B. Saunders Company, 1914</i>.)
Authors: E. N. B.
Journal: American Journal of Psychiatry (1915)
Hospital Administration
Authors: Nathaniel W. Faxon
Journal: New England Journal of Medicine (1952)

MacEachern1 has said that "The science and art of hospital administration are growing more complex due to the rapidly extending field of hospital service and the advance of scientific medicine."Hospital administration, which began as a lowly stewardship, is now recognized as an occupational specialty, requiring executive ability and, among other items, a thorough knowledge of public health, social service, business principles, hotel operation, finances, personnel practices and public relations. It is dignified by the conferring of the collegiate degree in hospital administration and under proper qualifications by membership or fellowship in the American College of Hospital Administrators. From a . . .
HYBRID CORONARY REVASCULARIZATION VERSUS CORONARY ARTERY BYPASS GRAFT IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE A META-ANALYSIS
Authors: Mohamed Zghouzi, Waqas Ullah, Hariogopal Sandhyavenu, Homam Moussa Pacha, Yasser Al-Khadra, Bachar Ahmad, Yasar Sattar, Abdul-Rahman Suleiman, Santiago Garcia, Rodrigo Bagur, Omar Ali, Delair Gardi, Zaher Hakim, Mohamed Mohamed, Muhammad Rashid, Mamas Mamas, M. Chadi Alraies
Journal: Journal of the American College of Cardiology (2021)
A large radiolucent pelvic mass in an 81-year-old woman
Authors: W. Z. Stern
Journal: JAMA (1982)

<h3>History</h3> An 81-year-old woman was admitted to the hospital with a complaint of weakness and constipation. Her temperature was 38.7 °C and her WBC count was 38,300/cu mm. Physical examination suggested the presence of a large pelvic tumor. An abdominal roentgenogram showed a large, spheroid, radiolucent mass, extending from the pelvis into the lower abdomen (Fig 1). <h3>Diagnosis</h3> Squamous cell carcinoma arising in benign ovarian cystic teratoma, with fistulous communication to the sigmoid colon. A barium enema (Fig 2) showed passage of barium into the radiolucent mass. The patient underwent a resection of the pelvic mass and sigmoid colon, colostomy, hysterectomy, and bilateral salpingo-oophorectomy. The tumor was dumbbell-shaped, with a small solid portion containing a few teeth and a large gas-filled portion. The latter was lined by squamous cell carcinoma, which was also present in the fistulous communication to the sigmoid. The patient's postoperative course was complicated by cardiac arrhythmia
Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors
Authors: Eva Wardelmann, Katharina Biermann, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Nadja Thomas, Reinhard Büttner, Torsten Pietsch, Thomas Heinicke, Nicola Speidel, Daniel Pink, Peter Reichardt, Peter Hohenberger
Journal: Clinical Cancer Research (2006)
A health questionnaire based on paper-and-pencil medium individualized and produced by computer. I. Technique
Authors: J. G. Mayne
Journal: JAMA (1969)

The relatively inexpensive mark-sense paper-and-pencil technique for administering a computer-generated and computer-processed health questionnaire is easy for patients to understand, simple to revise, and permits large-scale testing at low cost. The total questionnaire is designed to be administered in two or more portions or levels. Because each level after the first is a more detailed inquiry into positive responses made to questions of preceding levels, this multilevel approach permits the inquiry to be individualized to the patient. The questionnaires are generated from a question library, and the completed forms are read by an optical scanner. A summary of the patient's responses is printed for the physician's use.
Effect of Chemical Thymectomy on Skin Homografts
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marriages.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drinking coffee and carbonated beverages blocks absorption of nicotine from nicotine polacrilex gum
Authors: J. E. Henningfield
Journal: JAMA (1990)

Patients failing to obtain benefit from nicotine polacrilex gum in their efforts to quit smoking may be inadvertently blocking nicotine absorption. Effective nicotine absorption depends on the mildly alkaline saliva that is produced when buffering agents in the polacrilex are released along with nicotine as the polacrilex is chewed. We found that intermittent mouth rinsing with coffee or cola, but not distilled water, substantially reduced salivary pH and nicotine absorption. Because many commonly consumed substances were also found to be highly acidic, we recommend that patients do not ingest any substance during or immediately before nicotine polacrilex use. (<i>JAMA</i>. 1990;264:1560-1564)