tbuckley/cabot-search huggingface dataset:
Drugs for emotional disorders. Current problems
Authors: L. E. Hollister
Journal: JAMA (1975)

EMOTIONAL disorders, or what is termed "mental illness," may be both more frequent and more incapacitating than any other disease or disorder. Exact determinations of frequency are impossible, as many, if not most, instances are either unrecognized or unreported. A recent survey estimated that in any given year 15% of adults (about 20 million people) may suffer serious depressive symptoms.<sup>1</sup>Yet this is only one of many emotional disorders. At any given moment, almost 2 million people are under some formal treatment for emotional disorders, and psychiatrists now outnumber pediatricians and obstetricians. Most treatment is given by nonpsychiatrists, with probably one half of all visits to family or personal physicians being based on a primary or secondary emotional disorder. The degree of incapacity varies greatly. Where I live, suicides, accidents (often a pseudosuicide), and alcoholism (cirrhosis of the liver) rank high among the ten leading causes of death. Excluding
Acne
Authors: Sarah Purdy, David de Berker
Journal: BMJ (2006)

Acne is an easily treated cause of disfigurement and psychological morbidity.It affects more than 80% of people at some point in their life, 1 up to 14% of whom consult their general practitioner (GP) and 0.3% a dermatologist.About 3.5 million consultations with GPs occur in the United Kingdom annually for acne.w1 Morbidity can be high and associated with disfigurement, pain, loss of confidence, and impairment of normal social and workplace function, with documented effects on quality of life including depression, dysmorphobia, and even suicide.w2 w3 What are the clinical features of acne?In most cases it is not difficult to diagnose acne.It comprises a combination of papules, pustules, blackheads and whiteheads (open and closed comedones), nodules, and scarring.Background redness and greasy skin, known as seborrhoea, usually occur.It is important to avoid confusion with other conditions such as acne rosacea (box 1).Treatment with systemic corticosteroids can cause steroid induced acne, and the use of anabolic steroids can cause "bodybuilders acne."Potent topical steroid treatment can cause perioral or periorbital dermatitis with papules and pustules.Pustular drug eruptions and bacterial and fungal folliculitis can also resemble acne but can be distinguished by the absence of comedones.Typically, acne persists over years.Nodules can be more painful, more unsightly, and carry a greater risk of scarring than more superficial disease.In acne conglobata, nodules are widespread with interconnecting channels containing haemorrhagic, purulent exudate.When this evolves rapidly with fever, arthritis, and neutrophilia it is called acne fulminans.Postinflammatory pigmentation can last months and occasionally years, especially in patients with dark skin.The upper chest and shoulders may develop hypertrophic or keloid scarring for 12 months or more.Atrophic or "ice pick" scars are typically found on the face.Small depressions and mild discoloration may last for six to 12 months, but usually settle.Grading of acne is useful for recording the progress of disease or making treatment decisions. 2As a basic tool in clinical practice it is worth noting the presence or absence of the diagnostic components and their severity with a three point scale.Nodules, scarring (including keloids), and psychosocial burden are particularly important to note.
Incubation Period in Tetanus
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vitallium Skull Plates
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transactions of the Medical Society of the State of New York for the year 1897.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1233: Myeloperoxidase (MPO) activity in myeloid-derived suppressor cells (MDSCs): effects on anticancer drug activity
Authors: Jack C. Yalowich, Ragu Kanagasabai, Colleen S. Netherby, Michelle N. Messmer, Scott I. Abrams
Journal: Cancer Research (2019)

Abstract In cancer, suppression of host immunity is related, in part, to immature myeloid-derived suppressor cells (MDSCs) expanded in response to various tumor- or stroma-derived factors. Here, the expression and activity of myeloperoxidase (MPO) was examined in both granulocytic (PMN) and monocytic (M) MDSC subsets recovered from the spleens of 4T1 tumor-bearing mice, as well as interferon regulatory factor-8 (IRF8) knockout mice (IRF8-/-) which develop high levels of MDSCs due to IRF8-deficiency. Phenotypically identical cells from non-tumor-bearing mice served as controls. In addition, the role of MPO in PMN-MDSCs as a determinant of DNA damage induced by the anticancer agents etoposide (VP-16), camptothecin (CPT) and parthenolide (PTL), was evaluated for potential immunomodulatory effects. MPO protein content was ~4-fold greater in PMN-MDSCs from tumor-bearing compared to non-tumor-bearing mice, while MPO specific activity was equivalent in these two populations. MPO protein content in PMN-MDSCs from IRF8-/- mice was at least comparable to levels found in tumor-bearing hosts. In both IRF8-/- and tumor-bearing mice, PMN-MDSCs contained 5-10-fold greater MPO protein and overall enzyme activity compared to isolated M-MDSCs. VP-16 (5 µM)- and PTL (100 µM)-induced DNA strand breaks were 4-fold greater in PMN- compared to M-MDSCs from tumor-bearing mice. In addition, the heme-synthesis inhibitor, succinylacetone (SA) reduced MPO activity 2-3-fold in PMN-MDSCs from tumor-bearing mice with a corresponding decrease in drug-induced DNA damage for both VP-16 and PTL with no effect on CPT-induced DNA damage. The antioxidant dehydroascorbate decreased VP-16-induced DNA damage in PMN-MDSCs containing MPO activity, but not in those cells pre-incubated with SA to deplete MPO. These results indicate that MPO-dependent activation of VP-16 and PTL enhance DNA damage. Antioxidant protection against VP-16-induced DNA damage is consistent with MPO-mediated oxidative activation of VP-16 to a redox-cycling phenoxyl radical (Mol. Pharmacol. 79: 479-487, 2011). Overall, these results suggest that: 1) PTL may be useful to eliminate PMN-MDSCs; 2) MPO activation of VP-16 in PMN-MDSCs may be deleterious via oxidative DNA damage resulting in mixed-lineage leukemia (MLL) gene rearrangements known to be causal for therapy-related myeloid leukemias. Support: CA172105; CA090787; CA140622 Citation Format: Jack C. Yalowich, Ragu Kanagasabai, Colleen S. Netherby, Michelle N. Messmer, Scott I. Abrams. Myeloperoxidase (MPO) activity in myeloid-derived suppressor cells (MDSCs): effects on anticancer drug activity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1233.
Essential Pathology
Authors: John H. Raach
Journal: JAMA (1961)

For the student preparing to practice or do research, this is a well-conceived handbook. The author has been concise and brief in his descriptions of pathology, but in doing so, has not sacrificed essential facts. Normal structure and function are omitted because the author believes they should be reviewed in the standard textbooks of anatomy, physiology, and biochemistry. The principles of disease are reviewed in the first few chapters to refresh the reader's memory that the body's reaction to injury is by inflammation, that tumors represent an uncontrolled growth of cells, and that vascular diseases are frequently the result of fatty changes. All the organs of the body and the diseases which afflict them are adequately discussed. There are numerous photographs of gross and microscopic specimens in black and white. Short summaries of case histories illustrating the various pathological conditions are frequently included. At the end of each chapter there
Trepanation
Authors: Isidore Cohn
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In your editorial on trepanation (<i>JAMA</i><b>176</b>:1111 [July 1] 1961), the date of the founding of the University of San Marcos in Lima is given as 1535. I believe that this date is incorrect. I have before me a souvenir medallion which was presented to me during the celebration of the fourth century since the founding of the university, which bears the following inscription: "Universidad National Mayor de San Marcos por Centenario de su Fundacion, 1551-12 de Mayo 1951, Lima."
Effects of Calcium Supplementation on Pregnancy-Induced Hypertension-Reply
Authors: David A. McCarron
Journal: JAMA (1996)

<h3>In Reply.</h3> —The letters of Drs Roberts and D'Abarno and of Drs Levine and DerSimonian provide valuable insights to the challenges the obstetrical community faces in providing optimal prenatal care, particularly in a society in which first pregnancies are occurring in more women younger than 20 years. In responding to the article by Bucher et al,<sup>1</sup>they point out appropriately that an increase in blood pressure during the last trimester of gestation does not necessarily equate with an increased risk of preeclampsia and the adverse maternal and fetal outcomes associated with this condition. Levine and DerSimonian further suggest that a significant increase in blood pressure may be a "normal" response during gestation with no adverse consequences to either mother or child. Both letters conclude that provision of sufficient calcium to pregnant women cannot be justified by the findings of Bucher et al.<sup>1</sup> However, that interpretation fails to consider the potential
Safety of latex prick skin testing in allergic patients
Authors: B. Bonnekoh
Journal: JAMA (1992)

<h3>In Reply.</h3> —This is not the first patient reported to have a possible anaphylactic reaction with the latex prick skin test.<sup>1</sup>Any potent allergen skin test in exquisitely sensitive patients has this risk. The latex testing extract is properly labeled as "may cause anaphylaxis." However, if properly done, the latex prick skin test is very safe. We have safely skin tested 115 patients,<sup>2,3</sup>20 of whom had severe latex allergy. Our experience agrees with that of others.<sup>4</sup>The skin test needs to be carefully watched and immediately wiped clean with isopropyl alcohol after a positive result. This may be as soon as 5 to 7 minutes after the test. I question whether the patient reported by Bonnekoh and Merk had an anaphylactic event. There was minimal local reaction at the test site and, in patients with anaphylaxis, we generally see a large local wheal and flare. The
Evaluation of Mesoridazine. (Serentil)
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Coronary Drug Project. Initial findings leading to modifications of its research protocol
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Yesterday's triumphs: today's problems
Authors: W. H. Feldman
Journal: JAMA (1965)

During the past 100 years, human society has made astonishing advancements in the knowledge of disease. These have usually come about through tedious research accompanied by persistence and optimism. A large increment of the information acquired has been put to beneficent use in endeavors to identify, treat, prevent, suppress, and eradicate many of the formidable microbial, viral, and parasitic enemies of mankind. In the United States, the results have been amazingly successful. By Herculean efforts and constant vigilance, such fearsome diseases as yellow fever, diphtheria, typhoid fever, smallpox, foot-andmouth disease of cattle, tuberculosis due to<i>Mycobacterium bovis</i>, and more recently poliomyelitis, are virtually extinct. The purpose of this essay is to examine the anachronism that certain infectious diseases continue to threaten the lives of human beings despite knowledge concerning their diagnosis, prophylaxis, and treatment that research has provided. Among these diseases are tuberculosis, rabies, and the venereal diseases, gonorrhea and
International Conference on Vaccines Against Viral and Rickettsial Diseases
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Facteurs endoscopiques qui influencent la détection des polypes dentelés : une étude multicentrique
Journal: Endoscopy (2018)

Les polypes festonnés sessiles, plus fréquents dans le colon droit, sont de détection plus difficile en coloscopie. Ils sont une des causes principales des cancers d’intervalle. Les facteurs qui influencent la détection de ces polypes sont peu connus, en particulier les facteurs liés aux opérateurs.
THE IMMUNOLOGICAL SPECIFICITY OF TYPE II PNEUMOCOCCUS AND ITS SEPARATION INTO PARTIAL SPECIFICITIES. II
Authors: Michael Heidelberger
Journal: The Journal of Experimental Medicine (1960)

Quantitative data are given on the cross reactions in Type II antipneumococcal horse sera of plant gums and hemicelluloses containing multiple terminal groupings of glucuronic acid and/or 4-O-methylglucuronic acid. Great variability is shown both in the reactivities of the polysaccharides and in the antibodies in the sera of different animals immunized with the same antigen. The 4-O-methyl substituent on the glucuronic acid residues in a gum often appears to diminish cross-precipitation with antibodies to S II.
Chronic Diseases in the Rubber Industry
Authors: H. A. Tyroler, Dragana Andjelkovic, Robert Harris, Wayne Lednar, Anthony McMichael, Mike Symons
Journal: Environmental Health Perspectives (1976)

An overview is presented of epidemiologic studies of chronic diseases in the rubber industry. Analyses of the mortality experience during the period 1964-1972 of workers age 40–64 and retirees age 65–84 of two large rubber and tire manufacturing companies consistently disclosed excesses of deaths attributed to leukemia and lymphosarcoma, and for cancers of the stomach, large intestine, and prostate. The relation of site-specific malignancies to work histories and grouped occupational titles as surrogate measures of work-related exposures to possible carcinogens is described. There was no evidence of company-wide, sizable, consistent excess for the other major chronic diseases causes of death. Although a total cohort deficit in the mortality rate for lung cancer was found, there was a history of increased frequency of exposure to certain work areas among lung cancer decedents. Morbidity studies, including analysis of disability retirements, and ad hoc questionnaire and health testing surveys, disclosed excesses of chronic pulmonary diseases. There was evidence of an interactive effect in the association of work and smoking histories with pulmonary disability retirement.
THE DANGER OF EYE INFECTION BY SPECTACLES.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal