tbuckley/cabot-search huggingface dataset:
Medical aspects of sports
Authors: A. J. Ryan
Journal: JAMA (1965)

Although physicians have been interested in L sports, games, and exercise at least from the time of the Greek Olympiads, athletic medicine as a special field of interest is modern in concept. The growing interest in all medical aspects of sports is characterized by a multiplication of organized professional groups, publications, and conferences devoted to this subject. The effects are being noted favorably in improved coordination of the efforts of medicine with those of athletic personnel and in better standards of care of our athletes. Since ancient times, physicians have been interested in games and sports and in exercises of a gymnastic character as they relate to health. Herodicus, a contemporary of Hippocrates in the fifth century, BC, was the first Greek physician to whom we can trace the use of therapeutic gymnastics. He practiced this form of therapy so enthusiastically that he drew a rebuke from Hippocrates for treating
His bundle electrograms in a patient with hyperkalemia
Authors: L. Gould
Journal: JAMA (1974)

TO OUR knowledge, His bundle electrograms have never been obtained from a patient with hyperkalemia. We describe serial His bundle electrograms obtained from a patient with hyperkalemia caused by exogenous administration of potassium. <h3>Report of a Case</h3> An 80-year-old woman was admitted to Fordham Hospital because of shortness of breath. She was in excellent health until six months before admission when occasional bouts of dyspnea on exertion appeared. These episodes became more severe in the week preceding the hospitalization. On examination, her blood pressure was 160/80 mm Hg, her pulse rate was 90 beats per minute, with occasional premature beats, and her temperature was 38.2 C (100.8 F). Neck veins were prominent and rales were heard at both lung bases. The point of maximal cardiac impulse was in the sixth intercostal space beyond the midclavicular line. There were no murmurs or gallops. The liver was two fingerbreadths below the right
A Fib
Authors: Ellen Steinbaum
Journal: JAMA (2021)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4084: Radiation enhances efficacy of TEM1-specific cancer vaccination
Authors: Stefano Pierini, Mireia Uribe-Herranz, Renzo Perales-Linares, Silvia Beghi, Francesca Costabile, Sergei Pustylnikov, Andrea Facciabene
Journal: Cancer Research (2019)

Abstract Tumor endothelial marker 1 (TEM1 or CD248) is a protein found in both tumor vasculature and stroma. In prior experiments, we showed that immunizing with Tem1-TT plasmid-DNA (Tem1 cDNA fused to the minimal domain of the C fragment of tetanus toxoid) was effective in controlling tumor progression in three mouse tumor models in a T cell-dependent manner. Moreover, effective Tem1-TT vaccination reduced tumor vascularity without impacting normal angiogenesis. Radiation therapy (RT) is an established curative and palliative cancer treatment regimen which uses high-energy radiation to kill cancer cells. RT modulates the tumor microenvironment - by increasing MHC-I expression, inducing immunological cell death, and damaging the tumor-associated vasculature - potentially synergizing with anti-cancer immunotherapies. Here, we combined RT and Tem1-TT heterologous vaccination and showed that combination of the two therapies was more effective in controlling CT26 and TC1 tumor progression than either single therapy alone. Interestingly adding RT to Tem1-TT vaccine resulted in a stronger vaccine-specific immune response and increased epitope spreading toward gp70, a TAA expressed by CT26 tumor cell line. Further analysis of the tumor microenvironment revealed a significant increment of PD-L1 expression in both tumor cells and tumor vasculature after single or either combination therapy. This led us to test whether blocking the PD1/PD-L1 axe would further improve the efficacy of RT plus Tem1-TT therapy. Our results demonstrate that administration of anti-PD-L1 antibody further synergized with RT plus Tem1-TT and improved mice survival. In conclusion, triple combination of Tem1-TT vaccine, RT and anti-PD-L1 can offer a therapeutic advantage for TEM1-positive tumors which also express PD-L1. Citation Format: Stefano Pierini, Mireia Uribe-Herranz, Renzo Perales-Linares, Silvia Beghi, Francesca Costabile, Sergei Pustylnikov, Andrea Facciabene. Radiation enhances efficacy of TEM1-specific cancer vaccination [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4084.
THE ACCELERATION OF TISSUE GROWTH
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Junior Hospital Staff Contract
Authors: D. Murphy, C. M. Furnival, D. Macintyre, A. Pack, I. R. McDougall, D. M. Ward, J. F. MacKenzie, W. F. Kean, P. Stromberg, G. M. McKendrick, D. Brown, G. McIntyre, B. L. Devine, I. N. Scobie, D. C. C. Owens, A. Strong, A. R. M. W. M. Dougall, D. R. T. Gundry, C. E. Langan, M. M. Berry, D. E. Mitchell, M. H. Delaney, J. Reilly, W. G. Campbell, K. R. Patel, A. Shenkin, P. R. Beck, M. C. Smith, M. McEnaney, A. D. Howie, A. Milne, A. K. Henderson, G. Boyd, I. D. Hay, C. McKillop, J. McKillop, J. A. Burton, P. M. Kyle, I. Mackenzie, K. A. McLay, B. F. O'Reilly, J. Carlin, D. L. Citrin, M. J. Smyth, J. M. Simms, H. J. G. Burns, D. Henry, W. F. Bremner, J. L. H. C. Third, R. G. Murray, J. V. Jones, G. Lowe, R. D. Sturrock, P. J. Rooney, A. L. C. McLay, B. F. Boyce, W. D. Thompson, W. A. Reid, J. Rodger, R. P. O'Hare, K. A. Fleming, K. O'Reilly, A. M. McNicol, W. S. Stockwell, N. M. Pettigrew, J. M. Bell, A. Harvie, D. R. Morgan, M. Walker, None Punnyadasa, J. F. Winchester, I. M. R. Rogers
Journal: BMJ (1975)
Bronchial hyperresponsiveness and airway inflammation markers in nonasthmatics with allergic rhinitis
Authors: R. Polosa, I. Ciamarra, G Mangano, G Prosperini, M.P Pistorio, C Vancheri, N Crimi
Journal: European Respiratory Journal (2000)

Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma which is often associated with airways inflammation. However, some patients with allergic rhinitis and no clinical evidence of asthma also exhibit BHR. This study therefore investigated whether inflammatory cell infiltrate is present in the induced sputum of nonasthmatic subjects with allergic rhinitis during the pollen season and examined its relationship with airway hyperresponsiveness to inhaled methacholine and adenosine 59-monophosphate (AMP). Twenty subjects (12 allergic rhinitis, eight nonallergic controls) underwent methacholine and AMP challenge and sputum induction with hypertonic saline on separate days. Cell differentials were calculated from whole sputum samples. A significantly greater number of eosinophils was found in the sputum of nonasthmatic subjects with allergic rhinitis compared to that of nonallergic controls, their median (range) percentages being 17.5 (4-47) and 1.5 (0-5) (p&lt;0.001) respectively. Although sputum eosinophilia failed to be significantly associated with methacholine responsiveness (r(s)=-0.50; p=0.095), the provocative concentration of AMP causing a 20% fall in forced expiratory volume in one second correlated strongly and significantly with the absolute number of eosinophils (r(s)= -0.73; p=0.007). Eosinophil cationic protein levels in the sputum of rhinitic subjects were significantly elevated compared to controls and correlated with eosinophil number (r(s)=0.67; p=0.017). These findings support the view that bronchial eosinophilia alone is insufficient to cause asthmatic symptoms. Diverse agonists for assessing bronchial hyperresponsiveness are selectively associated with airway inflammation in allergic rhinitis.
Long-term diazepam therapy and clinical outcome
Authors: K. Rickels
Journal: JAMA (1983)

This double-blind study involved the continuous (six to 22 weeks) treatment of 180 chronically anxious outpatients with diazepam, 15 to 40 mg/day. Our findings indicate that a significant number of patients benefit from prolonged diazepam treatment and that tolerance to the anxiolytic effect of diazepam does not develop during a 22-week study period. The duration of continual treatment with sedative-benzodiazepines was clearly the most important determinant of withdrawal reactions. Patients treated continuously for less than eight months with sedative-benzodiazepines had an incidence of withdrawal of 5%, whereas 43% of patients treated for eight months or more demonstrated clear withdrawal reactions. While these withdrawal reactions produced considerable distress, they were neither life threatening nor incapacitating and did not include convulsions or psychotic reactions. In all cases, withdrawal reactions could be readily managed by gradually tapering the dose of the benzodiazepine. (<i>JAMA</i>1983;250:767-771)
Why a little aspirin is better than a lot
Authors: B. Merz
Journal: JAMA (1987)

WHILE CLINICAL investigators continue their empirical search for the optimum aspirin dose to prevent thrombogenesis, basic researchers have been looking at the effect of aspirin on two prostaglandins that are instrumental in clot formation. Laboratory studies have determined that aspirin inhibits the production of cyclo-oxygenase, an enzyme that is essential for the production of thromboxane (TXA<sub>2</sub>), which promotes platelet aggregation, as well as for the synthesis of prostacyclin (PGI<sub>2</sub>), which inhibits platelet aggregation. Fortunately, aspirin's effects on TXA<sub>2</sub>, which is produced by platelets, are longer lasting. Because platelets are not capable of producing new supplies of cyclo-oxygenase, the resumption of TXA<sub>2</sub>production requires 48 hours— the time it takes to release a new generation of platelets. In contrast, PGI<sub>2</sub>is produced by endothelial cells, which are capable of cyclo-oxygenase production. As soon as aspirin therapy is discontinued, the endothelium resumes cyclo-oxygenase production. As a result,
EDITORIAL NOTES.
Journal: JAMA (1892)

<h3>The Insanity of Egotism.</h3> —An article has appeared in the<i>North American Review</i>, entitled "A Modern Form of Insanity," by Dr. H. S. Williams, which throws some interesting lights upon those indifferently understood persons "the cranks." Dr. Williams holds that the great majority of these unfortunates are diseased mentally. The disease has been termed " paranoia," and more than any other insanity is the result of an inherited mental instability. The progenitors may not have been insane, but they may have been nervously unstable from drunkenness or from some wasting disease. The offspring may be merely nervous; he may have epilepsy or chorea; he may be insane. At the best, he may usually, if properly educated, learn to understand himself and to live a sane and useful life. We have here to do, however, only with the cases in which a wrong environing influence aids in the development of a particular
Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells
Authors: Kohshi Ohishi, Barbara Varnum-Finney, Irwin D. Bernstein
Journal: Journal of Clinical Investigation (2002)

We investigated the effect of Notch signaling, a known regulator of cell fate in numerous developmental systems, on human hematopoietic precursors. We show that activation of endogenous Notch signaling in human CD34+CD38– cord blood precursors with immobilized Delta-1 in serum-free cultures containing fibronectin and hematopoietic growth factors inhibited myeloid differentiation and induced a 100-fold increase in the number of CD34+ cells compared with control cultures. Immobilized Delta-1 also induced a multifold expansion of cells with the phenotype of common lymphoid precursors (CD34+CD7+CD45RA+) and promoted the development of cytoplasmic CD3+ T/NK cell precursors. IL-7 enhanced the promotion of T/NK cell differentiation by immobilized Delta-1, but granulocytic differentiation occurred when G-CSF was added. Transplantation into immunodeficient mice showed a substantial increase in myeloid and B cell engraftment in the marrow and also revealed thymic repopulation by CD3+ T cells due to cells being cultured for a longer period with immobilized Delta-1. These data suggest that Delta-1 can enhance myeloid and lymphoid marrow-repopulating ability and promote the generation of thymus-repopulating T cell precursors.
Not Married
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Marriages
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contents
Authors: P Ge, B Runyon, N Furusyo, E Ogawa, M Nakamuta, E Kajiwara, H Nomura, K Dohmen, K Takahashi, T Satoh, K Azuma, A Kawano, Y Tanabe, K Kotoh, S Shimoda, J Hayashi, J Rockstroh, L Peters, D Grint, V Soriano, P Reiss, A D', Arminio Monforte, M Beniowski, M Losso, O Kirk, B Kupfer, A Mocroft, Eurosida In Eurocoord, A Mangia, R Santoro, M Copetti, M Massari, V Piazzolla, E Spada, G Cappucci, G Missale, L Mottola, E Agostinacchio, L Di Mauro, O Zuccaro, P Maio, F Pellegrini, A Folgori, C Ferrari, B Langhans, B Kra, M Louis, H Nischalke, R Hu, A Staratschek-Jox, M Odenthal, S Manekeller, M Schepke, J Kalff, H.-P Fischer, J Schultze, U Spengler, R Lichtinghagen, D Pietsch, H Bantel, M Manns, K Brand, M Bahr, M Merli, C Lucidi, I Pentassuglio, V Giannelli, M Giusto, V Gregorio, C Pasquale, S Nardelli, B Lattanzi, M Venditti, O Riggio, R D'ambrosio, A Aghemo, M Fraquelli, M Rumi, M Donato, V Paradis, P Bedossa, M Colombo, F Morando, G Maresio, S Piano, S Fasolato, M Cavallin, A Romano, S Rosi, E Gola, A Frigo, M Stanco, C Destro, G Rupolo, D Mantoan, A Gatta, P Angeli, A Tripodi, M Primignani, L Lemma, V Chantarangkul, P Mannucci, L Mensa, S Pe ´rez-Del-Pulgar, G Crespo, G Koutsoudakis, C Ferna ´ndez-Carrillo, M Coto-Llerena, R Miquel, H Allende, L Castells, M Navasa, X Forns, G Otto, M Schuchmann, M Hoppe-Lotichius, M Heise, A Weinmann, T Hansen, M Pitton, I Que ´tier, N Brezillon, M Duriez, H Massinet, E Giang, J Ahodantin, C Lamant, M.-N Brunelle, P Soussan, D Kremsdorf, Y Morita, T Sakaguchi, K Ikegami, N Goto-Inoue, T Hayasaka, V Hang, H Tanaka, T Harada, Y Shibasaki, A Suzuki, K Fukumoto, K Inaba, M Murakami, M Setou, H Konno
Journal: Journal of Hepatology (2013)
Corrigenda
Journal: BMJ (1945)

Allergy to Citrus Fruit Q.-Last autumn and this I have frequently noticed crops of vesicles in infants and young children, on arms, legs, and sometimes the body.Attacks tend to recur over a period of weeks or months; the vesicles are usually irritable, start as red spots, then become blisters, and gradually disappear; they may reappear in a week or so; size 1/8 in. to 1/4 in.; they may become pustular.Mother and clinic usually blame oranges.What are the aetiology and treat- ment, and does diet or vitamin deficiency play a part in causation ?A.-The description does not give enough detail to alloW of a definite diagnosis, but the occurrence among a number of young children suggests a common factor, and if an unusual form of urticaria can be excluded, and such parasitic conditions as scabies, then it is not unreasonable to suspect oranges, because the citrus.fruits are well known to cause allergic reactions of different sorts.
Scientific program
Authors: Bronchospasm Ahrens, G Hilavetz, H Teresi, C Lux, Paul Chervinsky, Jeffrey Grossman, No Md, M Dartmouth, N Albany, Asthma Dvorin, D Goldstein, Therapy Uchida, M Sakurai, El Fournier, Lymphokine Tsicopoulos, A Tonnel, A Vorng, Il Joseph, B Uallaert, J Pestel, J Kusnierz, S Homer, J Portnoy, Sten Dreborg, Roland Phd, R Davies, M Tounbis, R Md Sapsford, J Robinson, I Reed, K Agrawal, B Butcher, C O'neil, Azole Gruchalla, Rebecca Md, T Sullivan, R Klotz, F Carpenter, G Uashington, J Girgis-Gabardo, A Dolovich, J Hanrilton, Canada Ontario, Progenitors Gibson, P Hepperle, H Kline, P Girgis-Gabardo, A Ramsdale, E Denburg, Jerry Dolovich, Iurunoblot Crosby, B Ledowc, R Veughan, T Ueber, R-U Goochan, D Aurora, Igm Cgmporents, Susan Berdy, Thomas Bergner, Kurt Bloch, Bernhard Md, Thermography De Ueck, A Gluck, U Derer, T Sasmaarmatter, U Staub, Ruben Marquez, Garcia Md, Marie Dim, Rita Md, San Juan, Marie Townsend, D Feeny, G Phd Guyatt, Hamilton Md, Mexico Canseco, C Leal, H Mora, G Galindo, Atopy Yun, T Kambera, Johnson Phd, J Kang, Blooo Ownby, D Mccullough, J Johnson, C Detroit
Journal: Journal of Allergy and Clinical Immunology (1990)
Clinical Disorders of Acid-Base Equilibrium
Authors: Saulo Klahr
Journal: JAMA (1968)

Most of the clinical abnormalities of acid-base balance are self-limited. They relate either to an increase in the number of hydrogen ions entering the extracellular fluid (ECF) or to an extracorporeal loss of base. Sustained abnormalities most often result from disease of one of the two major organs concerned with acid-base regulation, the lung or the kidney. A rational approach to the diagnosis and management of acid-base abnormalities requires an understanding of the physiologic processes concerned with hydrogen ion regulation. Conceptual clarity in this area has been abetted by the widespread utilization of the Bronsted-Lowry concept of acids and bases. In this view, simply stated, an acid is a proton donor and a base is a proton acceptor.<sup>1</sup>Buffers minimize changes in hydrogen ion concentration by converting strong (completely ionized) acids and bases into weaker (less completely dissociated) acids and bases, respectively. In man, the major physiologically active buffer
A randomized trial in postmenopausal patients with advanced breast cancer comparing endocrine and cytotoxic therapy given sequentially or in combination. The Australian and New Zealand Breast Cancer Trials Group, Clinical Oncological Society of Australia.
Journal: Journal of Clinical Oncology (1986)

A prospective randomized clinical trial was performed in 339 postmenopausal patients with advanced breast cancer. Two single modality treatment sequences, doxorubicin plus cyclophosphamide (AC) followed on failure by tamoxifen (TAM), and TAM followed by AC, were compared with combined modality chemo-endocrine therapy (TAM plus AC). The response rate to initial TAM (22.1%) was inferior to that for AC (45.1%), and for TAM plus AC (51.3%). However, patients randomized to the sequence TAM followed by AC showed a 42.5% overall tumor response to sequential protocol therapy, similar to the 46.9% for those randomized to AC followed by TAM. Furthermore, survival in all three arms was almost identical. Adverse prognostic factors for survival were liver metastases, short disease-free interval, poor performance status, and prior adjuvant chemotherapy. In no subgroup was significantly better survival associated with initial cytotoxic therapy. Endocrine therapy followed on failure by cytotoxics is appropriate for postmenopausal patients with advanced breast cancer.