tbuckley/cabot-search huggingface dataset:
Quantitative comparison of genetic effects of ethylating agents on the basis of DNA adduct formation. Use of O6-ethylguanine as molecular dosimeter for extrapolation from cells in culture to the mouse.
Authors: A A van Zeeland, G R Mohn, A Neuhäuser-Klaus, U H Ehling
Journal: Environmental Health Perspectives (1985)

DNA-adduct formation and induction of gene mutations were determined simultaneously after treatment with the four ethylating agents, ethyl methanesulfonate (EMS), ethylnitrosourea (ENU), diethyl sulfate (DES), and N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). Both, in E. coli K-12 (NAL-resistance) and in V79 Chinese hamster cells in culture (HPRT-deficiency), the frequencies of mutation induction by all chemicals were the same when plotted against the amount of O6-ethylguanine formed in DNA, suggesting that this DNA adduct can be used as a common dosimeter for the comparisons of the frequencies of gene mutations induced by ethylating agents in various mutagenicity assay systems. Using ENU, such a comparison was performed between mutation induction in V79 cells in vitro and in the specific-locus assay in the mouse. The data indicate that at equal levels of O6-ethylguanine in the DNA of V79 cells and in testicular DNA from male mice treated with ENU, the frequencies of induced mutants in both assay systems were quite similar. These results support the concept that the determination of premutagenic DNA adducts in vivo can be used to monitor exposure to chemical mutagens and that genetic risk estimations may ultimately be performed on the basis of such measurements and of comparative mutagenesis in vitro and in vivo.
Goldfish
Authors: Kristin Camitta Zimet
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surveillance of nosocomial infections by antibiotic monitoring
Authors: L. Feldman
Journal: JAMA (1979)

Records of all patients receiving intravenous gentamicin sulfate during a 92-day interval were reviewed to detect nosocomial infections that had been missed by routine surveillance. Only 46 of 48 of the 99 treatment courses had been detected. In 96% of cases not detected by routine surveillance, use of gentamicin was considered justified. Of the patients missed by surveillance, 83% were in oncology wards, and 46% had severe neutropenia and fever of unknown origin. Antibiotic surveillance proved a useful adjunct in estimating the incidence of nosocomial infections in such patients. (<i>JAMA</i>241:2806-2807, 1979)
"KEEP AWAY FROM MONTREAL"
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OXYGEN INFLATIONS OF PERITONEAL CAVITY IN TUBERCULOUS EXUDATIVE PERITONITIS
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicine's Wars in Vietnam
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alcohol-Induced Respiratory Symptoms Are Common in Patients with Aspirin Exacerbated Respiratory Disease (AERD)
Authors: Juan Carlos Cardet, Andrew A. White, Nora A. Barrett, Anna M. Feldweg, Paige G. Wickner, Jessica Savage, Neil Bhattacharyya, Tanya M. Laidlaw
Journal: Journal of Allergy and Clinical Immunology (2013)
The Cider House Rules
Authors: Donald E. Riesenberg
Journal: JAMA (1986)

Abortion is a problem of enormous proportions for which there is no universally correct solution. Such is the grist for novelist John Irving's powerful mill—his six books are not for the fainthearted. In<i>The World According to Garp</i>, Irving explored the relationship between a writer and his iconoclastic mother; homosexuality and radical feminism were also at issue.<i>The Hotel New Hampshire</i>looked at family tragedy, terrorism, and incest. Now he takes on abortion in<i>The Cider House Rules</i>. Irving chose early 20th-century New England as the setting for his new book. Not coincidentally, his grandfather, Dr Frederick C. Irving, practiced obstetrics in Boston during that time. As explained in an extensive appendix, the elder Irving produced such works as<i>A Textbook of Obstetrics and The Expectant Mother's Handbook</i>and was professor of obstetrics at Harvard (as well as chief of staff of the Boston Lying-in Hospital). The Cider House Rules
Error in Abstract
Authors: Steven Frucht, Michael Aminoff
Journal: JAMA Neurology (2018)

Daniel Martinez-Ramirez, MD; Joohi Jimenez-Shahed, MD; James Frederick Leckman, MD; Mauro Porta, MD; Domenico Servello, MD; Fan-Gang Meng, MD, PhD; Jens Kuhn, MD; Daniel Huys, MD; Juan Carlos Baldermann, MD; Thomas Foltynie, PhD, MRCP; Marwan I. Hariz, MD, PhD; Eileen M. Joyce, MD, PhD; Ludvic Zrinzo, MD; Zinovia Kefalopoulou, MD, PhD; Peter Silburn, MD; Terry Coyne, MD; Alon Y. Mogilner, MD, PhD; Michael H. Pourfar, MD; Suketu M. Khandhar, MD; Man Auyeung, MD, FHKCP, FHKAM; Jill Louise Ostrem, MD; Veerle Visser-Vandewalle, MD; Marie-Laure Welter, MD; Luc Mallet, MD, PhD; Carine Karachi, MD, PhD; Jean Luc Houeto, MD; Bryan Timothy Klassen, MD; Linda Ackermans, MD, PhD; Takanobu Kaido, MD, PhD; Yasin Temel, MD; Robert E. Gross, MD, PhD; Harrison C. Walker, MD; Andres M. Lozano, MD, PhD; Benjamin L. Walter, MD; Zoltan Mari, MD; William S. Anderson, MD; Barbara Kelly Changizi, MD; Elena Moro, MD, PhD; Sarah Elizabeth Zauber, MD; Lauren E. Schrock, MD; Jian-Guo Zhang, MD; Wei Hu, MD; Kyle Rizer, BS; Erin H. Monari, PhD; Kelly D. Foote, MD; Irene A. Malaty, MD; Wissam Deeb, MD; Aysegul Gunduz, PhD; Michael S. Okun, MD
Cancer
Authors: Scott M. Browning
Journal: JAMA (1994)

<i>Cancer</i>is a book with an ambitious task, to "present a balanced, well-informed account of the many facets of cancer" to the interested nonprofessional public. Part 1 reviews the biology of cancer with emphasis on molecular genetics, part 2 discusses the cancer patient with a general introduction to the technology and jargon of clinical medicine, and part 3 reviews the 10 most common cancers. Where this book on cancer distinguishes itself from many others aimed at the public is in its discussion of molecular biology and the genetics of cancer. Through a historical perspective tracing various milestones of medical discovery, the reader is brought to the frontiers of knowledge on such topics as oncogenes, protooncogenes, retrovirus biology, cell transformation, DNA translocation, point mutation, tumor suppressor genes, and the molecular biology of metastasis. These are rather heady topics and not for the faint of heart, but concepts are gradually and lucidly
Ankylosing Spondylitis
Authors: J. Cyriax
Journal: BMJ (1949)

limmo 633virus ") into a mouse can nevertheless bring about a sarcomatous transformation of the supporting stroma ?And how, especially in view of this last query, does he regard the fact that no such agent or virus has so far been found in epithelial tumours in spite of intense search for such a body ?The reasons for my asking these questions will be found in an article (with references) by myself in the Edinburgh Medical
VIENNA
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analyses of Food Preparation.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NEW METHOD OF TREATMENT FOR INOPERABLE CARCINOMA OF THE BREAST.
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract B1-43: Cancer drug response networks built for comparative cancer pharmacogenomics identifies combination therapies for repositioning
Authors: Douglas Brubaker, Elena Svenson, Smith Kai, Maya Monroe, Christopher Ryu, Goutham Narla, Mark R. Chance, Gurkan Bebek
Journal: Cancer Research (2015)

Abstract We present an integrative framework for classifying drug response: CAncer Drug Response nEtworks (CADREs). We built CADREs for drugs with differential sensitivity profiles in cancer cell lines by integrating baseline copy number, gene expression, and drug sensitivity data for the cell lines. The nodes in the network are drugs and the edges are weighted according to the number of shared copy number variations, differentially expressed genes, and dysregulated pathways present in sensitive cell lines at baseline. These baseline features were mapped into pathways to generate a Pathway CADRE, and were also integrated into a differential gene expression and copy number Feature CADRE. CADREs were built for breast, ovarian, and endometrial cancers individually and combined to assess shared and unique features of drug sensitivity. Analyzing CADRE clusters associated multiple gene features and pathways with sensitivity to frontline therapies used in combination in these cancers. We identified four clusters of breast cancer drugs whose effectiveness is driven by a shared core of pathways. Compounds that were used in combination in clinical trials tended to not share an edge or are completely disconnected in networks. Specifically, ten such drug pairs in our breast CADREs have been found to work in combination in breast cancer and an additional five have been used in combination in other cancers, representing opportunities for repositioning these combinations in breast cancer. Examining highly interconnected CADRE nodes gave us an understanding for compounds that might work best together. Citation Format: Douglas Brubaker, Elena Svenson, Smith Kai, Maya Monroe, Christopher Ryu, Goutham Narla, Mark R. Chance, Gurkan Bebek. Cancer drug response networks built for comparative cancer pharmacogenomics identifies combination therapies for repositioning. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B1-43.
Is There a Connection between Carbon Monoxide Exposure and Hypertension?
Authors: David G. Penney, John W. Howley
Journal: Environmental Health Perspectives (1991)

Exposure to carbon monoxide in our society is a frequent occurrence, from auto exhaust, industrial effluents, and cigarette smoke, and takes place over a wide range of concentrations. It has been suggested that chronic CO inhalation may alter blood pressure, even possibly provoking hypertension by acting alone or in combination with other environmental stressors. Some studies examining the response to CO exposure have reported decreases in blood pressure, whereas others have found increases or no change. Blood pressure in long-term cigarette smokers is generally decreased relative to nonsmokers, albeit a slight decrease. The strength of this finding is somewhat clouded by the effect of the lower body weight in smokers. The increases in blood pressure observed acutely with smoking are mainly due to nicotine. Chronically, the hypertensive action of nicotine is largely offset by the hypotensive action of CO. Several studies support the notion that environmental CO exposure or smoking accelerates or exacerbates hypertension in some people. It has been asserted that chronic CO exposure increases the development of atherosclerotic disease; however, convincing evidence from animal experiments is lacking. Nevertheless, CO may elevate plasma cholesterol and does appear to enhance atherosclerosis when serum cholesterol is greatly elevated by diet. Using the borderline hypertensive rat, an animal model reputed to have increased sensitivity to environmental stimuli, we found no evidence to suggest a provocatory role for CO in the development of hypertension; instead, CO exposure produced hypotension. On the whole, the human and animal literature, as well as our studies, fail to support the hypothesis that long-term CO exposure is capable of provoking an increase in blood pressure, even in borderline hypertensive or sensitive individuals.
Prevention and control of acquired immunodeficiency syndrome. An interim report
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Allergic reactions to insulin
Authors: P. Lieberman
Journal: JAMA (1971)

Two of five patients with acute systemic allergic reactions to insulin injection required desensitization. Immunologic studies consisted of direct skin testing with a variety of insulins which included human and synthetic insulins. Passive cutaneous transfer, leukocyte histamine release, and radioimmunodiffusion studies were also performed. Fifty diabetic patients without symptoms of insulin allergy were also selected for skin testing with a variety of insulin preparations. Results indicated that insulin allergy may be directed against the insulin molecule itself or against protein contaminants in the commercially available preparation, and that it can be mediated by IgE. Desensitization resulted in precipitous drops in reaginic antibody titers and cutaneous sensitivity, with the simultaneous induction of tolerance to insulin.
Book Review Carbohydrate Metabolism: Four papers presented in a symposium held at the meeting of the American Physiological Society at Toronto, Canada, April 29, 1939. Reprinted from Endocrinology, 26:285-351, 1940 . By various authors. 4°, paper, 67 pp., with 6 charts and 14 tables. Menosha, Wisconsin: George Banta Publishing Company, 1940. $1.00.
Journal: New England Journal of Medicine (1940)
Change in ultraviolet (UV) transmission following the application of vaseline to non-irradiated and UVB-exposed split skin
Authors: K. Hoffmann, K. Kaspar, T. Gambichler, P. Altmeyer
Journal: British Journal of Dermatology (2000)

Journal Article Change in ultraviolet (UV) transmission following the application of vaseline to non‐irradiated and UVB‐exposed split skin Get access K. Hoffmann, K. Hoffmann Department of Dermatology, Clinical and Experimental Photodermatology, Ruhr University Bochum, Gudrunstrasse 56, D‐44791 Bochum, Germany Dr Klaus Hoffmann. E‐mail: K.Hoffmann@derma.de Search for other works by this author on: Oxford Academic Google Scholar K. Kaspar, K. Kaspar Department of Dermatology, Clinical and Experimental Photodermatology, Ruhr University Bochum, Gudrunstrasse 56, D‐44791 Bochum, Germany Search for other works by this author on: Oxford Academic Google Scholar T. Gambichler, T. Gambichler Department of Dermatology, Clinical and Experimental Photodermatology, Ruhr University Bochum, Gudrunstrasse 56, D‐44791 Bochum, Germany Search for other works by this author on: Oxford Academic Google Scholar P. Altmeyer P. Altmeyer Department of Dermatology, Clinical and Experimental Photodermatology, Ruhr University Bochum, Gudrunstrasse 56, D‐44791 Bochum, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 3, 1 September 2000, Pages 532–538, https://doi.org/10.1111/j.1365-2133.2000.03706.x Published: 01 September 2000