tbuckley/cabot-search huggingface dataset:
STRANGE VARIATIONS
Journal: JAMA (1990)

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Amer J of Mental Deficiency, Albany, NY
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Indigenous Chagas' disease (American trypanosomiasis) in California
Authors: R. J. Schiffler
Journal: JAMA (1984)

CHAGAS' disease (American trypanosomiasis) is an infection caused by the protozoan parasite<i>Trypanosoma</i><i>cruzi</i>. Despite the presence of the parasite in<i>Triatoma</i>insects (the vector of T<i>cruzi</i>) and mammals across the southern United States,<sup>1</sup>only two patients with indigenous Chagas' disease have been described<sup>2,3</sup>; both were infants from Texas in 1955. We report herein the first recognized case of indigenous Chagas' disease in California and the first case reported in the United States since 1955. <h3>Report of a Case</h3> In August 1982, a 56-year-old woman from Lake Don Pedro, Calif, 120 miles east of San Francisco, was admitted to the hospital after 16 days of fever. The patient had lived in east-central California for 19 years. She had traveled outside the United States only once, when she visited the California-Mexico border town of Mexicali for an afternoon in 1978. She had never received blood transfusions, nor did
Elective Hysterectomy
Authors: Lonny Myers
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Congratulations to Drs Haynes and Pearse for agreeing that under some circumstances hysterectomy is the rational method of sterilization (235:2801, 1976). However, the article as a whole appears to be far too male-scientific-, and statistic-oriented. I find a lack of sensitivity to the needs and wants of the patient. Methods of sterilization, whether vasectomy, tubal ligation or hysterectomy, are<i>patient decisions</i>. Physicians should always be informative and honest about the risks and consequences and offer advice when that is appropriate. For a 30-year-old woman, information regarding tubal ligation should include the fact that there will be more than 200 needless menstrual periods, with loss of blood including iron and other nutrients. Information regarding hysterectomy would include the prospect of additional risk and prolonged incapacitation. But for many intelligent women interested in making decisions regarding their own bodies, whether to do a tubal ligation or hysterectomy is rightfully
Randomized Phase II Trial of Combination Idiotype Vaccine and Anti-CD3/Anti-CD28 Costimulated Autologous T Cells in Patients with Multiple Myeloma Post-Autotransplantation
Authors: Muzaffar H. Qazilbash, Edward A Stadtmauer, Veera Baladandayuthapani, Heather Lin, Beryl M. Tross, Medhavi Honhar, Soung-Chul Cha, Kunhwa Kim, Sheetal S Rao, Michael Popescu, Nina Shah, Qaiser Bashir, Krina Patel, Elizabeth J. Shpall, Donna M. Weber, Sheeba K. Thomas, Jatin J. Shah, Robert Z. Orlowski, Naseem DS Kerr, Alfred L. Garfall, Adam D. Cohen, Karen Dengel, Carl H June, Richard E. Champlin, Larry Kwak
Journal: Blood (2016)
LIMITATIONS OF BACTERIOPHAGE THERAPY
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Relationship between Mutagenicity and Chemical Composition of Polycyclic Aromatic Compounds from Coal Pyrolysis
Authors: Mary J. Wornat, Andrew G. Braun, Alexandra Hawiger, John P. Longwell, Adel F. Sarofim
Journal: Environmental Health Perspectives (1990)

The polycyclic aromatic compounds (PAC) produced from the pyrolysis of a bituminous coal at temperatures of 1125 to 1425 degrees K prove to be mutagenic to S. typhimurium, both in the presence and in the absence of postmitochondrial supernatant (PMS) prepared from Aroclor 1254-induced rat liver. Mutagenicity of the PAC samples measured in the absence of PMS exhibits little dependence on pyrolysis temperature; that measured in its presence is higher at the higher pyrolysis temperatures. However, because of the decrease in PAC yield as the temperature is raised, mutagenicity per mass of coal consumed falls with an increase in temperature if measured without PMS (-PMS) and peaks at an intermediate temperature of 1378 degrees K if measured with PMS (+PMS). Using a new chromatographic technique, we have split each coal-derived PAC sample into two fractions: LC1, containing PAC with alkyl and O-containing substitutions and LC2, consisting of unsubstituted PAC. Substituted (LC1) fractions show no significant +PMS mutagenicity, indicating that, as a whole, the alkylated PAC in our coal pyrolysis products are not mutagenic. Only at the higher temperatures do the substituted fractions exhibit significant -PMS mutagenicity, attributed to PAC with carbonyl or etheric functionalities. The extremely low yields of the substituted PAC under the conditions where they show some activity, however, ensure that they contribute little to overall mutagenicity. In contrast to the substituted fractions, the unsubstituted (LC2) fractions display significant mutagenicity under all conditions and appear to be responsible for virtually all of the mutagenicity in these coal-derived PAC samples. In this fraction, -PMS activity is attributed to nitrogen-containing heterocyclic aromatics.
Die Zuckerkrankheit: Leitfaden für Studierende und Ärzte
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The 10th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2019), Sapporo, Japan, August 29-31, 2019
Journal: Liver Cancer (2019)

Background: Since 1990's, we have suggested that the laparoscopic liver resection (LLR) can provide favorable outcome with early postoperative recovery in selected patients with liver disease including Hepatocellular carcinoma.Minor LLRs, such as left lateral sectionectomy or partial hepatectomy in antero-lateral region of the liver, have been favorable procedures performed laparoscopically.With accumulation of our experience, advanced procedures, which means hepatectomy in postero-superior region or anatomically oriented resections including Major LLRs, have been utilized.Surgical Technique and Method: Fundamental technique of LLR, which includes maintenance of operative field, choice and use of instruments, isolation and division of vessels, control of hemostasis, can be learned in Minor LLRs.As well as technical stylization, utilization of perioperative diagnostic modality, such as 3D-CT, Ultrasonography (US) and Indocyanine green near-infrared fluorescence (ICG-NIR) imaging, can help to have decision in disease diagnosis, trocar positioning and way of liver transection.In our concept for division of hepatic hilar vessels in anatomical hepatectomy, individual isolation approach is used for hemi-hepatectomy, and Glissonean pedicle approach is used for resection smaller than hemi-hepatectomy.Positive and negative staining technique for detection of portal inflow territory using ICG-NIR is utilized in anatomical hepatectomy.Results: Three hundred two patients suffering liver disease received LLR.No severe postoperative morbidity above Clavien-Dindo Grade IIIb, except one patient developed cerebral infarction, was observed.In recent series, one third of cases are anatomical resections including Major LLRs.ICG-NIR can help to perform LLR, especially in cirrhotic liver or post-adhesiolysis.Staining technique could contribute to have precise territory based on hepatic anatomy, even in laparoscopic setting. Conclusion:We believe that benefits of LLR are not only minimally invasiveness, but also precise performance of surgery.
Evaluation of a New Hypnotic Agent
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tibial fixation
Authors: E G Hardy
Journal: BMJ (1992)

Sen's editorial,' may well be due to tuberculosis; rates there now are comparable with those in the United Kingdom during part of the last century.Tuberculosis is, to a great extent, a disease of social deprivation, and thus Sen's point is valid.For some reason, however, young females have a higher mortality from tuberculosis than their male peers; this phenomenon is not yet understood and may account for at least some of Sen's missing women.
Abstract 2454: Long-Term Administration of Thiazolidinedione Provides Multiple Antiatherosclerotic Effects Independent of Diabetic Improvement for Type-2 Diabetics With Coronary Artery Disease Receiving Statin
Authors: Tatsuaki Murakami, Hiromasa Kokado
Journal: Circulation (2007)

Background: Insulin resistance and type-2 diabetes mellitus are thought to be highly involved in complex atherothrombogenic processes, but the long-term effects of insulin sensitizing agents remain partially clarified. We assessed hypothesis that long-term use of thiazolidinedi-one, an insulin sensitizer, pleiotropically inhibits atherosclerotic progression in patients treated with statin one of the standard antiatherosclerotic therapies. Methods: Thirty type-2 diabetic patients with stable coronary artery disease were randomized to group-T where they received troglitazone (400mg/day) or pioglitazone (30mg/day), or to group-C where they continued therapy without thiazolidinedione for more than 2 years. We noninvasively quantified flow-mediated dilation of brachial artery after 5 minutes forearm occlusion (FMD), dilation of brachial artery after sublingual administration of nitroglycerin (TNG), and intima-media thickness of common carotid artery (IMT) using high-resolution ultrasonography. Changes in FMD, TNG, and IMT were compared between the 2 groups. Results: All the patients in group-T (n=15) manifested good compliance to the treatment and improvements in diabetic variables represented by HbA1c while group-C showed no improvement. FMD (%) increased after medication in group-T (p&lt;0.01) but remained unchanged in group-C (p=0.84). TNG (%) remained unchanged in group-T (p=0.13) and in group-C (p=0.76). IMT (mm) decreased in group-T (p=0.04) but remained unchanged in group-C (p=0.21). Changes of FMD or IMT did not correlate to those of HbA1c (FMD: r=0.20, p=0.74, IMT: r=0.25, p=0.49). Conclusion: These results indicate long-term therapy with thiazolidinedione in diabetic patients receiving statin additionally improves endothelial function and reduces arterial wall thickness independent of reversal for clinical glucose metabolic status, which may have novel potential benefit for management of atherosclerosis in type-2 diabetics.
Colonic Polyps
Authors: Frederick W. Ackroyd, Stephen E. Hedberg
Journal: Annual Review of Medicine (1985)

Carcinoma of the large bowel arises almost exclusively in neoplastic polyps, which are present in 5-10% of the population over age 40. These polyps may be of three histologic types: (a) tubular adenoma (adenomatous polyp), (b) tubulovillous adenoma (villoglandular polyp), and (c) villous adenoma. The tendency for malignant change is greatest in the villous adenoma (41%) and in tubulovillous (villoglandular polyps--23%). In tubular adenomas (simple adenomatous polyps), the incidence of malignancy is 5% over all. The tendency toward malignant change is determined by histologic type, size, and degree of atypicality of adenoma. Early detection and complete removal of neoplastic polyps of the colon are essential to the prevention of cancer of the large bowel, and this may usually be done in most cases with the colonoscope.
Editorial: Operability of lung cancer.
Journal: BMJ (1975)

Monday morning" angina in workers in nitroglycerin factories, attributed to nitrate withdrawal, possibly also derives from coronary spasm preventable or relieved by nitrates.The Prinzmetal variant with ST elevation probably represents coronary spasm which lasts too little time to bring about infarction but too long to be associated with ST depression.ST elevation is known to be an early electrocardiographic event in patients who go on to develop frank changes of infarction, and it is probable that less or shorter lived spasm may be associated with more mundane E.C.G. changes of ischaemia, while even more prolonged spasm might cause infarction or death (with or without thrombosis at the site of spasm).
MEDICAL LICENSURE STATISTICS FOR 1941
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“Effect of different asthma treatments on risk of cold-related exacerbations.” H.K. Reddel, C. Jenkins, S. Quirce, M.R. Sears, E.D. Bateman, P.M. O'Byrne, M. Humbert, R. Buhl, T. Harrison, G.G. Brusselle, A. Thorén, U. Sjöbring, S. Peterson, O. Östlund and G.S. Eriksson.<i>Eur Respir J</i>2011; 38: 584–593.: Figure 4
Authors: H Reddel, C Jenkins, S Quirce, M Sears, E Bateman, P O'byrne, M Humbert, R Buhl, T Harrison, G Brusselle, A Thore ´n, U Sjo ¨bring, S Peterson
Journal: European Respiratory Journal (2012)
Hospital Infections
Authors: Mike Mitka
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EXTH-47. THERAPEUTIC REVERSAL OF PRENATAL PONTINE ID1 SIGNALING IN DIPG
Authors: Micah Harris, Vivekanand Yadav, Stefanie Stallard, Rinette Woo, Robert Siddaway, Tingting Qin, Brendan Mullan, Zachary Miklja, Ruby Siada, Ramya Ravindran, Xuhong Cao, Amy Pasternak, Maria Castro, Pedro Lowenstein, Rajen Mody, Arul Chinnaiyan, Cynthia Hawkins, Sean McAllister, Pierre Desprez, Sriram Venneti, Carl Koschmann
Journal: Neuro-Oncology (2019)

Abstract Diffuse intrinsic pontine gliomas (DIPGs) are lethal brain tumors with no effective therapies other than radiation. Inhibitor of DNA binding (ID) proteins are key regulators of tissue and lineage-specific gene differentiation during embryogenesis. Previous work has shown that H3F3A and ACVR1 mutations increase ID1 expression in cultured astrocytes, but this has not been validated in human DIPG, nor has the regulation and targetability of ID1 been explored in DIPG. Analysis of multi-focal post-mortem tumor and normal brain tissue (n=52) as well as multiple human datasets revealed ID1 to be elevated in DIPG. Elevated ID1 was found to correlate with reduced survival in DIPG. In a multi-focal autopsy DIPG case, we found ID1 expression to be heterogeneous and to correlate with tumor invasion. Chromatin immunoprecipitation-qPCR (ChIP-qPCR) was used to quantify H3K27ac and H3K27me3 at ID1 gene regulatory regions (promoters/enhancers) in multi-focal post-mortem tissue. The ID1 loci was found to be epigenetically poised for up-regulation (elevated H3K27ac and low H3K27me3) in DIPG tissue, regardless of H3 or ACVR1 mutation status, compared to normal brain. Analysis of publically-available ISH and ChIP-sequencing data revealed elevated ID1 expression and ID1-enhancer H3K27ac in prenatal mouse hindbrain compared to prenatal forebrain, prenatal midbrain, and all postnatal brain regions. ID1 shRNA-mediated knockdown of primary human H3K27M DIPG cells (DIPG007) resulted in significantly reduced invasion and migration. As cannabidiol (CBD) has successfully been used to therapeutically target ID1 in pre-clinical models of adult human cancers, we treated DIPG007 cells with CBD and found reduced viability at clinically relevant dosing (IC50=2.4 uM) with dose-dependent reduction in ID1 protein. ID1 knockdown and CBD treatment studies in murine models of DIPG are ongoing. These findings indicate that a multifactorial (genetic and regionally-based) epigenetic upregulation of ID1 drives DIPG invasiveness and is targetable with CBD.