tbuckley/cabot-search huggingface dataset:
Travel-associated legionnaires’ disease in Europe: 2005
Authors: K D Ricketts, B McNaught, C A Joseph, Collective European Working Group for Legionella Infections
Journal: Eurosurveillance (2007)

In 2005, 755 cases of travel-associated legionnaires’ disease with onset in 2005 were reported to the EWGLINET surveillance scheme by 20 countries. A total of 85.8% of cases were diagnosed by the urinary antigen test, and 37 cultures were obtained. Twenty nine deaths were reported, giving a case fatality rate of 3.8% (down from 5.6% in 2004). Ninety three new clusters were identified, 36.6% of which would not have been detected without the EWGLINET scheme. One hundred and twenty two accommodation sites were investigated and the names of nine sites were published on the EWGLI website.
Questions and Answers
Authors: Richard M. Glass
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Prevalence of Psychiatric Disorders Among Cancer Patients
Authors: Leonard R. Derogatis
Journal: JAMA (1983)

Two hundred fifteen randomly accessed cancer patients who were new admissions to three collaborating cancer centers were examined for the presence of formal psychiatric disorder. Each patient was assessed in a common protocol via a psychiatric interview and standardized psychological tests. The American Psychiatric Association's<i>DSM-III</i>diagnostic system was used in making the diagnoses. Results indicated that 47% of the patients received a<i>DSM-III</i>diagnosis, with 44% being diagnosed as manifesting a clinical syndrome and 3% with personality disorders. Approximately 68% of the psychiatric diagnoses consisted of adjustment disorders, with 13% representing major affective disorders (depression). The remaining diagnoses were split among organic mental disorders (8%), personality disorders (7%), and anxiety disorders (4%). Approximately 85% of those patients with a positive psychiatric condition were experiencing a disorder with depression or anxiety as the central symptom. The large majority of conditions were judged to represent highly treatable disorders. (<i>JAMA</i>1983;249:751-757)
Diagnostic and therapeutic technology assessment. Chemonucleolysis for herniated lumbar disk
Journal: JAMA (1989)

The DATTA panelists did not achieve a definitive consensus on the use of chymopapain chemonucleolysis for a protruding lumbar disk contained by the annulus. Concerns about safety, especially the risk of anaphylaxis and the risk of damage to the spinal cord, were frequent. The effectiveness of this procedure for this indication was also questioned by many of the panelists. The panel did agree that chemonucleolysis is unacceptable as either safe or effective for use in patients with a herniated lumbar disk that is extruding nucleus pulposus through the annulus. Accordingly, diagnostic imaging of any suspect disk must be performed before chemonucleolysis can be deemed appropriate for any individual patient. Current imaging techniques are not infallible and cannot confer an absolute sense of security when seeming to indicate a nonextruded protruding disk.
Influence of Chlorothiazide Upon the Cardiovascular Response to Vasoconstrictor Drug, Phenylephrine
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Poster Session 4: Portal Hypertension - Experimental
Journal: Hepatology (2014)

1173ADAAs.IDX21459 showed minimal cytotoxicity in mammalian cell types, and it exhibited no or low inhibition of key human enzymes and transporters.Genotoxicity testing in vitro and in vivo was also negative.Favorable ADME properties included rapid absorption, rapid and complete excretion, high hepatic uptake and efficient metabolism.IDX21459 was well tolerated in rats and monkeys over 28 days with no cardiac effects, affirming the general safety of IDX21459 in vivo.Conclusions: The collective data presented here show a favorable biological, pharmacological and safety profile for IDX21459 that supported progression into clinical trials in HCV-infected patients.
DNA-Protein Complexes Induced by Chromate and Other Carcinogens
Authors: Max Costa
Journal: Environmental Health Perspectives (1991)

DNA-protein complexes induced in intact Chinese hamster ovary cells by chromate have been isolated, analyzed, and compared with those induced by cis-platinum, ultraviolet light, and formaldehyde. Actin has been identified as one of the major proteins complexed to DNA by chromate based upon its molecular weight, isoelectric point, positive reaction with an actin polyclonal antibody, and proteolytic mapping. Chromate and cis-platinum both complex proteins of similar molecular weight and isoelectric points, and these complexes can be disrupted by chelating agents and sulfhydryl reducing agents, suggesting that the metal itself is participating in binding rather than having a catalytic or indirect role (i.e., oxygen radicals). In contrast, formaldehyde complexed histones to the DNA, and these complexes were not disrupted by chelating or reducing agents. An antiserum raised to chromate-induced DNA-protein complexes reacted primarily with 97,000 kDa protein that did not silver stain. Slot blots, as well as Western blots, were used to detect formation of p97 DNA crosslinks. This protein was complexed to the DNA by all four agents studied.
Tumor Cells in Circulating Blood of Patients With Carcinoma of Breast and of Gastrointestinal Tract
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ipecacuanha Poisoning: Another Fatal Case
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Promotion of Endometriosis in Mice by Polychlorinated Dibenzo-p-Dioxins, Dibenzofurans, and Biphenyls
Authors: Krista L. Johnson, Audrey M. Cummings, Linda S. Birnbaum
Journal: Environmental Health Perspectives (1997)

Previous studies showed exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) enhances the development of endometriotic lesions. In this study we examined the effects of other polyhalogenated aromatic hydrocarbons on endometriotic proliferation. B6C3F1 female mice were treated via oral gavage a total of five times, with 3 weeks between each dosing, with 0, 1, 3, or 10 micrograms 2,3,7,8,-TCDD/kg body weight (bw); 3 or 30 mg 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153)/kg bw; 100, 300, or 1000 micrograms 3,3',4,4',5-pentachlorobiphenyl (PCB 126)/kg bw; 10, 30, or 100 micrograms 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF)/kg bw; or 2 or 20 mg 1,3,6,8-TCDD/kg at 10 ml/kg bw. Endometriosis was surgically induced during the week of the second dosing. Three weeks following the final dose, the mice were euthanized and endometriotic lesions, whole body, liver, ovaries, uterine horn, and thymus were weighted, and lesion diameters were measured. Lesions, uterine horns, and ovaries were fixed for histopathology and livers were processed for measurement of ethoxyresorufin O-deethylase (EROD) activity. Both 2,3,7,8-TCDD (1 and 3 micrograms/kg bw) and 4-PeCDF (100 micrograms/kg bw) significantly enhanced the growth of endometrial lesions. No statistically significant increase in endometriotic lesion size was detected in animals treated with either PCB 126 or with the highest dose of 2,3,7,8-TCDD, possibly due to the effects of histologically observed ovarian toxicity. The nondioxin-like compounds, PCB 153 and 1,3,6,8-TCDD, produced no observable effects on endometriosis. Hepatic EROD activity was significantly induced by 2,3,7,8-TCDD, 4-PeCDF, and PCB 126, but not by PCB 153 or 1,3,6,8-TCDD. The results of this study provide preliminary support for the hypothesis that halogenated aromatic hydrocarbon-promoted endometriosis may be Ah receptor mediated.
Lymphadenopathy Syndrome in Homosexual Men
Authors: Jonathan E. Kaplan
Journal: JAMA (1987)

Seventy-five homosexual men with lymphadenopathy syndrome (LAS) for three months or more and antibody against the human immunodeficiency virus were enrolled in a prospective study in Atlanta in 1982 and 1983. Fourteen developed the acquired immunodeficiency syndrome (AIDS) three to 38 months after enrollment in the study and five to 56 months after onset of LAS. The five-year cumulative incidence rate of AIDS after onset of LAS was 29%; yearly incidence rates showed no decreasing trend with time. Of 18 patients with constitutional symptoms and a low T-helper cell count at their first visit, nine developed AIDS; of the remaining 57 patients, five developed AIDS (five-year cumulative incidence rates, 57% and 18%, respectively,<i>P</i>&lt;.001). Patients with lymphadenopathy syndrome are at continuing risk for the development of AIDS. Those with constitutional symptoms and a low T-helper cell count at their first visit appear to be at higher risk; other LAS patients are at lower risk but may still develop AIDS. (<i>JAMA</i>1987;257:335-337)
Political campaign pinpoints 'stigma hurdle' facing nation's mental health community
Authors: C. A. Raymond
Journal: JAMA (1988)

THE CAMPAIGN to overcome cultural stigma attached to depression (<i>JAMA</i>1988;260:309-310) has received a boost from another campaign, the one for President of the United States. Candidate Michael S. Dukakis has been obliged to respond to allegations that he received professional treatment for depression. Although this was not the case; much of the reaction among the news media and elsewhere has been: What's wrong with being treated for a usually curable problem experienced by millions of persons? In recent presidential campaigns, perhaps in reaction to postmortem disclosures of serious illnesses of some past Presidents, the willingness or reluctance of a candidate to reveal medical history has in itself become a public issue. Candidates are now under pressure to disclose the minutiae of their personal health, from hemorrhoids to allergies. Personal physicians are being instructed to respond in detail to news media questions about their prominent patient's ailments and therapies. Greater
Further Studies on the Relationship of Intrascleral Venous Pressure and Eye Pressure
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevaccination screening of medical and dental students. Should low levels of antibody to hepatitis B surface antigen preclude vaccination?
Authors: R. P. Perrillo
Journal: JAMA (1983)

The prevalence of hepatitis B virus (HBV) markers in 484 medical and 329 dental students was studied. Three students (0.9%) were hepatitis B surface antigen (HBsAg) reactive, and 46 students (5.7%) were reactive for antibody to HBsAg (anti-HBs). There was no difference in anti-HBs frequency between medical and dental students, and the prevalence of this marker was not associated with year in school. Of the 46 reactors, eight (17%) were nonreproducible and 38 (83%) were reproducibly reactive when the same samples were reanalyzed. Of note, all nonreproducible reactors exhibited anti-HBs sample-negative control (S/N) ratios of less than 10, and none were positive for antibody to hepatitis B core antigen (anti-HBc). Nineteen (50%) of the reproducible reactors had anti-HBs S/N ratios equal to or greater than 10, and only 15 (39%) were anti-HBc positive. In view of these observations, we do not recommend HBV screening in a vaccine program for health students. Due to the frequency with which low-level anti-HBs reactors without anti-HBc are found to be nonreproducibly positive, we are concerned by the potential overinterpretation of such results before the formulation of decisions about the need for vaccination. (<i>JAMA</i>1983;250:2481-2484)
Correction: Helping Hand
Journal: BMJ (1980)

book Conquering Cancer (Allen Lane, J 6 50), caused a minor sensation in France.But that was three years ago, and it was, of course, France.The translated version has not lost its bite, nor can it be easily dismissed as parochial.If the press in Britain treat it as they did in France, they will ignore its accurate scientific content and delight in the personalia.For Israel highlights internecine strife caused by the "modernisation of cancer treatment."He castigates the cancer establishment in the shape of surgeons and radiotherapists for their refusal to recognise that cancer is a systemic disease.He criticises them for a blinkered view, focused, on local disease, and an inflexible attitude towards modern "chemo- therapies."The accusation, which hit the headlines in the French glossies, was that a patient with cancer was taking part in a lottery when he sought advice or treatment.In other words, the chance of cure depended on a random pattern of referral.On the topic of randomness, statisticians don't escape the notice of Professor Israel either.They and the growing band of medical oncologists are taken to task for idolising the controlled clinical trial, which, though it has a place, suffocates flair and innovation.This book may not cause questions to be asked in the House, but it will certainly give doctors some uncomfortable moments.Patients with cancer will read the book because of its optimistic title but also because they read all forms of journalism on the subject and avidly watch television's contributions, which are none too professional.Israel predicts that patients will have more say in the choice of potential treatments-for instance, women increasingly question the need for mutilating mastectomy and then, particularly in the United States, demand adjuvant chemotherapy.Israel's solution is to combine strategies for the benefit of the patient by dissolution of the mutual mistrust of individual cancer specialists.Each may then learn more of the other's art and then apply that knowledge instead of denying it-as is the rule at the present time.Vive la difference-non!-GMCV.
The Bridge at Ann Arbor: Japanese Health Program
Authors: M. Mitka
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Terminology
Authors: Alfred Yankauer
Journal: JAMA (1971)

<h3>To the Editor.—</h3> I have been closely involved with "Pediatric Nurse Associates." We prefer the term Nurse Practitioners in spite of the American Academy of Pediatrics suggestions for reasons given by Smith. We have also bemoaned the lack of accepted terminology. The current situation is indeed confusing. Nevertheless, I really doubt that semantics will solve the kind of confusion that really reflects flux, change, and uncertainty concerning the future of educational tracks and health service delivery. It seems to me unlikely that terminology will crystallize until the nittygritty of delivering health care has done so. Although the term primary care is reasonably well understood and accepted, the meaning of specialty care is not, and terms like ambulatory and institutional care describe only place, not function or caretakers. Smith seems to include surgeons and internist physicians both as primary and specialty caretakers but pediatricians and obstetricians only as specialty caretakers. He
Corticotropin in generalized myasthenia gravis. Effect of short, intensive courses
Authors: D. Grob
Journal: JAMA (1966)

The effect of short, intensive courses of corticotropin (100 units intravenously, daily for ten days) was studied in patients with generalized myasthenia gravis. A decrease in strength and response to anticholinesterase medication occurred during 21 of 22 courses in seven of eight patients. Following termination of corticotropin, moderate to marked improvement occurred after 13 of 21 courses in four of seven patients, and lasted an average of seven weeks. The exacerbation and improvement were more pronounced in patients with more severe myasthenia, and following repeated courses of corticotropin. The improvement was proportional to the severity of the exacerbation. The effects of corticotropin could be simulated by typhoid-paratyphoid vaccine. Despite exacerbation of the disease during hormone administration, repeated courses of corticotropin are useful in the management of most cases of severe myasthenia gravis.
Transarterial radioembolization versus systemic treatment for the management of hepatocellular carcinoma with vascular invasion: analysis of the US national cancer database
Authors: Joseph Ahn, Michael Luu, Mazen Noureddin, Walid Ayoub, Alexander Kuo, Vinay Sundaram, Andrew Klein, Todd Brennan, Irene Kim, Tsuyoshi Todo, Georgios Voidonikolas, Marc Friedman, Jonathan Steinberger, H. Gabriel Lipshutz, Andrew Hendifar, Jun Gong, Kambiz Kosari, Shelly C. Lu, Nicholas Nissen, Ju Dong Yang
Journal: Journal of Hepatology (2020)