tbuckley/cabot-search huggingface dataset:
Ueber Halluzinosen der Syphilitiker.
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POST-GRADUATE STUDY.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Heberden Society: Heberden Oration
Authors: Heberden Oration, Hans Selye, W Copeman
Journal: Annals of the Rheumatic Diseases (1950)

Prof. Selye began with the apology that much of what he had to say could only be vague, but said that a preliminary map of a country, even though incomplete and in some respects inaccurate, was a useful possession.In this sense he turned to the principal facts and theories upon which the general adaptation syndrome concept was based.The general adaptation syndrome (G.A.S.) was an integrated syndrome of closely inter- related adaptive reactions to non-specific stress.It developed in three stages: the alarm reaction, the stage of resistance, and the stage of exhaustion.Most of the characteristic manifestations of the alarm reaction, such as tissue catabolism, hypoglycaemia, gastro- intestinal erosions, disappeared or were reversed during the stage of resistance, but reappeared in the stage of exhaustion.In G.A.S. the manifestations of passive non-specific damage were intricately inter- mixed with those of active defence.In the biological sense, stress was the interaction between damage and defence.In addition to damage and defence, every stressor also produced certain specific actions-anaesthetics, for example, acted upon the nervous system, diuretics upon water metabolism, insulin upon blood sugar-quite apart from * The first part of Prof.
Exposure of Passengers and Flight Crew to Mycobacterium tuberculosis on Commercial Aircraft, 1992-1995
Journal: JAMA (1995)

From January 1993 through February 1995, CDC and state health departments completed investigations of six instances in which passengers or flight crew traveled on commercial aircraft while infectious with tuberculosis (TB). All six of these investigations involved symptomatic TB patients with acid-fast bacillus (AFB) smear-positive cavitary pulmonary TB, who were highly infectious at the time of the flight(s). In two instances, Mycobacterium tuberculosis isolated from the index patients was resistant to both isoniazid and rifampin; organisms isolated from other cases were susceptible to all antituberculous medications. In addition, in two instances, the index patients were aware of their TB at the time of travel and were in transit to the United States to obtain medical care. However, in none of six instances were the airlines aware of the TB in these passengers. This report summarizes the investigations by CDC and state health departments and provides guidance about notification of passengers and flight crew if an exposure to TB occurs during travel on commercial aircraft.
MINERS' CONSUMPTION
Authors: OTTO V. HUFFMAN
Journal: JAMA (1910)

i.king was equally skilful.I taught this woman how to make coffee, and her husband can now go into the hay-field without any difficulty.When a patient is told by a physician that he must diet, he goes on the theory that he must starve himself.The doctor does not tell him what lo eat and what not to eat.And here we err.There are plenty of good books on the market on dietetics.Buy them, inform yourselves, then give your patients definite rules as to what to eat and what to avoid.Db. C. (!. Ki'iu.kv.New York: Those of us who have Been much of life among the poor people in any large city will understand tin-truth of Dr. Sill's statement regarding their ignorance.I have been ill dispensary and hospital work for twenty-two years, and I ¡on impressed with the fact that it is not that these people have not enough money, but that they bave no idea of what constitutes nutritious foodj and children ¡ire not fed with the idea of body-building, but merely of satisfying Hie appetite.The mot hers are not lazy, they arc Untaught, and that is why they adopt a makeshift did ¡mil do the thing that is easiest.If tbe physician takes Ihe trouble to tell the mother what to do she does it.Ii is the primary function of the physician lo instruct people how to live.That may be done through organizations of different kinds.At present there is an organization in New York City which will give a "child-welfare exhibit" in November.This exhibit »illshow educated people the conditions that exist among the poor, and it will be made attractive by object lessons and demonstrations in order to draw the poor and show them the results which may be achieved by right living.By that exhibit a great deal will be accomplished.It will inform the best eluss of people how the others live and let the ignorant be taught what constitutes proper living.
Edith Cavell
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOKS IN REVIEW 1992
Authors: ERIC J. SEIFTER
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article BOOKS IN REVIEW 1992 Get access Cutaneous Melanoma, 2nd Edition , Charles M. Balch , Alan N. Houghton , Gerald W. Milton , Arthur J. Sober , Sengjaw Soong , eds. Philadelphia : J. B. Lippincott , 1992 . 583 pp., illus. $125. Reviewed by E. George Elias (J Natl Cancer Inst 84: 1358–1360 , 1992 ). ERIC J. SEIFTER ERIC J. SEIFTER Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 2, 20 January 1993, Page 159, https://doi.org/10.1093/jnci/85.2.159-a Published: 20 January 1993
Cystic fibrosis. Problems encountered with sweat testing
Authors: B. J. Rosenstein
Journal: JAMA (1978)

The sweat test is the only practical and reliable laboratory test for confirmation of the diagnosis of cystic fibrosis. Among 234 patients referred to The Johns Hopkins Hospital for sweat testing, 62 had had a previous test; 29 tests had been reported as negative, and 33 tests had been reported as positive. Results of quantitative pilocarpine-iontophoresis sweat tests at this center led to a change in diagnosis in 27 (43.5%) of these 62 patients. Most of the errors were false-positive. (<i>JAMA</i>240:1987-1988, 1978)
ORGANIZATION OF THE ARMY MEDICAL DEPARTMENT IN ACTIVE HOSTILITIES.
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LAW &amp;amp; MEDICINE
Authors: Angela Roddey Holder
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of smoking on the activity of ischemic heart disease
Authors: J Barry, K Mead, E G Nabel, M B Rocco, S Campbell, T Fenton, G H Mudge, A P Selwyn
Journal: JAMA (1989)

Cigarette smoking has been causally linked to coronary heart disease. To investigate the effect of smoking on the activity of ischemic heart disease, 65 patients with chronic stable manifestations of coronary disease and a positive exercise tolerance test underwent continuous ambulatory monitoring to quantify the amount of ischemic ST segment depression during daily life. Twenty-four smokers were compared with 41 nonsmokers for frequency and duration of electrocardiographic signs of ischemia during 24 hours. A total of 4968 hours of ambulatory monitoring were analyzed. The frequency of episodes was three times as often (median) and the duration of ischemia was 12 times longer (median duration, 24 vs 2 min/24 h) in smokers than nonsmokers. This finding remained statistically significant when a number of potentially confounding factors were controlled by means of logistic regression. This study shows that patients with coronary artery disease who smoke have significantly and substantially more active myocardial ischemia during daily life than patients who do not. (<i>JAMA</i>1989;261:398-402)
EXPERIMENTAL MEASLES.
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Herpesvirus Infection
Authors: S. Harvey Sklar
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Since there is little published detailed information on the natural history of many viral infections in untreated patients and there is also a tendency by clinical investigators to overinterpret normal recovery in treated patients, the focus for evaluation of antivirals is turning to controlled trials for evaluation.<sup>1</sup> In a preliminary clinical study of 65 cases (70% herpes zoster [HZ] and 30% herpes simplex [HS]), we have measured quantitatively the relationship between viral infection and blood nucleotide levels. Blood samples were taken within one week of illness in 30 cases of HZ and within 8 to 14 days in 15 cases. One half of the sampled patients with primary HS failed to give a history of prior infection, but no neutralizing antibody or skin tests were done. The remainder had clinically recurrent disease. With both clinical conditions, blood was taken when the vesicles were erupting or within
Waldenström's Macroglobulinemia (WM) Is Preceded By Clonal Lymphopoiesis Including MYD88 L265P in Progenitor B Cells
Authors: Sara Rodríguez, Cirino Botta, Jon Celay, Ibai Goicoechea, Maria J Garcia-Barchino, Rafael Valdés-Mas, Yolanda Carrasco, Daniel Alameda, Juan José Garcés, Marta Larrayoz, Susana Santos, Diego Alignani, Amaia Vilas-Zornoza, Erika Lorenzo-Vivas, Cristina Pérez Ruiz, Sonia Garate, Sarvide Sarai, Amaia Gascue, Christian Reinhardt, Isidro Sanchez-Garcia, Maria Jose Larrayoz, Maria Jose Calasanz, Felipe Prosper, Marina Motta, Antonella Anastasia, Antonio Sacco, Massimo Gentile, Sara Duarte, Helena Vitoria, Catarina Geraldes, Artur Paiva, Aldo M. Roccaro, Jesús San-Miguel, Jose Angel Martinez-Climent, Bruno Paiva
Journal: Blood (2019)
57 ACTIVITY OF TELAPREVIR ALONE OR IN COMBINATION WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN IN TREATMENT-NAIVE GENOTYPE 2 AND 3 HEPATITIS-C PATIENTS: FINAL RESULTS OF STUDY C209
Authors: G.R. Foster, C. Hezode, J.-P. Bronowicki, G. Carosi, O. Weiland, L. Verlinden, R. van Heeswijk, B. Van Baelen, G. Picchio, M. Beumont-Mauviel
Journal: Journal of Hepatology (2010)
Erratum
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOK REVIEWS
Authors: R. O. DILLMAN
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BOOK REVIEWS Get access Tumor Markers in Clinical Practice: Concepts and Applications. A. S. Daar, ed. Oxford: Blackwell, 1987, 400 pp. $52.50. ROBERT O. DILLMAN ROBERT O. DILLMAN Scripps Clinic and Research Foundation10666 North Torrey Pines Rd., La Jolla, CA 92037 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 4, 20 April 1988, Pages 286–287, https://doi.org/10.1093/jnci/80.4.286 Published: 20 April 1988
Calcified plaque in the cervical spine with pain and paresthesia
Authors: R. L. Goldwin
Journal: JAMA (1979)

<h3>History</h3> A 52-year-old diabetic woman was seen in the clinic for pain in her shoulder and left arm. She also complained of paresthesias in her left upper extremity for the previous 13 years. Past history showed head trauma at age 2 years following a 4-m fall. Physical examination of the neck showed normal flexion, extension to 60°, right lateral rotation to 60°, and left lateral rotation to 45°. No sensory deficit was detected in her left arm. Figure 1 shows the lateral film from the cervical spine series. <h3>Diagnosis</h3> Ossification of the posterior longitudinal ligament of the cervical spine ("Japanese disease"). <h3>Comment</h3> The initial roentgenograms (Fig 1) demonstrated a bony plaque along the posterior aspect of vertebral bodies C-2 to C-4. Osteoarthritic changes were noted at the C-5 to C-6 level. Additionally, an os odontoideum was seen at C-1 Anteroposterior and lateral tomograms (Fig 2 and 3) showed the ossified
correction to: Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial
Authors: W. Shi, T. Jiang, P. Nuciforo, C. Hatzis, E. Holmes, N. Harbeck, C. Sotiriou, L. Peña, S. Loi, D.D. Rosa, S. Chia, A. Wardley, T. Ueno, J. Rossari, H. Eidtmann, A. Armour, M. Piccart-Gebhart, D.L. Rimm, J. Baselga, L. Pusztai
Journal: Annals of Oncology (2018)

Background: We performed whole-exome sequencing of pretreatment biopsies and examined whether genome-wide metrics of overall mutational load, clonal heterogeneity or alterations at variant, gene, and pathway levels are associated with treatment response and survival.Patients and methods: Two hundred and three biopsies from the NeoALTTO trial were analyzed.Mutations were called with MuTect, and Strelka, using pooled normal DNA.Associations between DNA alterations and outcome were evaluated by logistic and Cox-proportional hazards regression.Results: There were no recurrent single gene mutations significantly associated with pathologic complete response (pCR), except PIK3CA [odds ratio (OR) ¼ 0.42, P ¼ 0.0185].Mutations in 33 of 714 pathways were significantly associated with response, but different genes were affected in different individuals.PIK3CA was present in 23 of these pathways defining a 'trastuzumab resistance-network' of 459 genes.Cases with mutations in this network had low pCR rates to trastuzumab (2/50, 4%) compared with cases with no mutations (9/16, 56%), OR ¼ 0.035; P < 0.001.Mutations in the 'Regulation of RhoA activity' pathway were associated with higher pCR rate to lapatinib (OR ¼ 14.8, adjusted P ¼ 0.001), lapatinib þ trastuzumab (OR ¼ 3.0, adjusted P ¼ 0.09), and all arms combined (OR ¼ 3.77, adjusted P ¼ 0.02).Patients (n ¼ 124) with mutations in the trastuzumab resistance network but intact RhoA pathway had 2% (1/41) pCR rate with trastuzumab alone (OR ¼ 0.026, P ¼ 0.001) but adding lapatinib increased pCR rate to 45% (17/38, OR ¼ 1.68, P ¼ 0.3).Patients (n ¼ 46) who had no mutations in either gene set had 6% pCR rate (1/15) with lapatinib, but had the highest pCR rate, 52% (8/15) with trastuzumab alone.Conclusions: Mutations in the RhoA pathway are associated with pCR to lapatinib and mutations in a PIK3CA-related network are associated with resistance to trastuzumab.The combined mutation status of these two pathways could define patients with very low response rate to trastuzumab alone that can be augmented by adding lapatinib or substituting trastuzumab with lapatinib.
THE PHYSICIAN AS TEACHER.
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal