tbuckley/cabot-search huggingface dataset:
Efficacy of BSI-201, a poly (ADP-ribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): Results of a randomized phase II trial
Authors: J. O'Shaughnessy, C. Osborne, J. Pippen, M. Yoffe, D. Patt, G. Monaghan, C. Rocha, V. Ossovskaya, B. Sherman, C. Bradley
Journal: Journal of Clinical Oncology (2009)

3 Background: TNBC is an aggressive breast cancer subtype that shares molecular and pathologic features with BRCA1-related breast cancers. BRCA-deficient cells are sensitive to inhibition of PARP1, a critical enzyme of cell proliferation and DNA repair, and thus represent a rational target of PARP inhibitor-based cancer therapy. The objectives of this study were to evaluate BSI-201, a potent PARP1 inhibitor, in combination with gemcitabine/carboplatin (G/C) in subjects with metastatic TNBC. Methods: Eligible subjects had measurable disease and had ≤2 prior cytotoxic regimens for ER-, PR-, and HER2-negative metastatic breast cancer. Patients were randomized (1:1) to G/C alone or G/C + BSI-201. Gemcitabine (1000 mg/m2) and carboplatin (AUC=2) were given on days 1 and 8, and BSI-201 (5.6 mg/kg; iv; biweekly) on days 1, 4, 8, and 11 every 21 days. Endpoints were clinical benefit rate (CBR = CR + PR + SD ≥6 months), progression-free survival (PFS) and overall survival (OS). Results: Analyses of the first 86 of a planned 120 patients showed that BSI-201 + G/C had improved CBR, median PFS, and median OS, compared with G/C alone. The frequency and nature of adverse events (AEs) did not differ between arms. Conclusions: This preliminary analysis demonstrates that BSI-201 + G/C significantly improves CBR, PFS, and OS, compared with G/C alone. BSI-201 + G/C was well tolerated, with BSI-201 adding no significant toxicity to G/C. Updated CBR, PFS, and OS for all 120 patients and exploratory correlative analyses of PARP expression and clinical response will be presented. G/C (n = 44) G/C+BSI−201 (n = 42) Hazard ratio (95% CI) P value CBR, % 12 52 0.0012 Median PFS, days 87 211 0.30 (0.15–0.59) 0.0003 Median OS, days 169 >254 0.24 (0.09–0.61) 0.0012 Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration BiPar Sciences, Inc.
Abstract 3484: Ras recruits oncogenic serine protease hepsin to disrupt mammary epithelial integrity
Authors: Topi A. Tervonen, Shishir M. Pant, Denis Belitskin, Johanna Englund, Katja Närhi, Emmy Verschuren, Panu Kovanen, Juha Klefström
Journal: Cancer Research (2019)

Abstract Type II transmembrane serine protease hepsin is overexpressed and redistributed in clinical breast cancer samples, although the HPN gene is not a frequent target of cancer-specific genetic alterations. Here, we sought to identify cancer relevant upstream factors responsible for oncogenic deregulation of hepsin. We explored the effects of ectopic expression of major oncogenes and tumor suppressors on hepsin protein expression levels in non-malignant mammary epithelial cells, finding that HrasV12, KrasV12, ectopic wild-type Kras, endogenous mutant KrasD12 and E2F-1 induce the expression of active form of hepsin. Oncogenic Ras proteins also reduced expression levels of cognate hepsin inhibitor, HAI-1. Concomitantly, oncogenic Ras expression led to disappearance of desmoplakin and desmoglein 2 from desmosomal junctions, which correlated with mislocalization of hepsin from its predominant localization in desmosomes to cytosol. To explore the effects of mutated Ras expressed at endogenous levels we used lung tumors derived from lox-stop-lox (LSL)-KrasD12; p53-/- and LSL-KrasV12 mammary epithelial structures in ex vivo 3D cultures. In both cases, hepsin was highly expressed and predominantly localized to cytosol. Knockdown of hepsin by shRNA rescued HrasV12-induced epithelial integrity defects in mammary epithelial 3D culture and furthermore, MEK and ERK inhibitors prevented HrasV12-induced hepsin deregulation as well as desmosomal and basement membrane defects. Critical pathways downstream of MAPK pathway are being studied and will be discussed. These findings suggest a critical role for hepsin in mediating Ras-MAPK-mediated disruption of epithelial integrity during tumorigenesis. Citation Format: Topi A. Tervonen, Shishir M. Pant, Denis Belitskin, Johanna Englund, Katja Närhi, Emmy Verschuren, Panu Kovanen, Juha Klefström. Ras recruits oncogenic serine protease hepsin to disrupt mammary epithelial integrity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3484.
Cause-specific long-term mortality rates in patients recovered from community-acquired pneumonia compared with the general Dutch population
Authors: Anke H.W. Bruns, Jan Jelrik Oosterheert, Marloes C. Cucciolillo, Rachida El Moussaoui, Rolf H.H. Groenwold, Jan M. Prins, Andy I.M. Hoepelman
Journal: Clinical Microbiology and Infection (2010)
Lipoproteins and the liver sieve: The role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis*1
Authors: R FRASER
Journal: Hepatology (1995)

The liver sieve, formed by the fenestrated hepatic sinusoidal endothelium, is a dynamic biofilter separating the hepatic blood from the plasma within the space of Disse. It filters macromolecules of differing sizes, especially lipoproteins. More specifically, it acts as a barrier to the large triglyceride-rich parent chylomicrons, while permitting the smaller triglyceride-depleted but cholesterol- and retinol-rich remnants to enter the space of Disse. There the remnants contact specific receptor sites on the hepatocyte microvilli. Thus, the liver sieve is the first site of hepatic selection and consequent metabolism of dietary cholesterol and fat-soluble vitamins, as well as rejection of dietary triglycerides. Therefore, perturbations of the porosity of the sieve, whether from changes in size, number of fenestrae, or composition of the underlying extracellular matrix within the space of Disse, will have a profound influence on the metabolism of lipoproteins. This disturbance of the homeostasis of lipids, including fat-soluble vitamins and cholesterol, as well as other macromolecules, may tilt the balance between health and disease in a variety of organs and tissues, such as the liver, kidney and arteries.
Endoscopy
Authors: Edward B. Benedict
Journal: New England Journal of Medicine (1959)

Benign StrictureBarrett69 has introduced the term, "lower esophagus lined by columnar epithelium," as more descriptive than so-called "congenital short esophagus," "ectopic gastric mucosa" or "lower esophagus lined by gastric epithelium." The condition is thought to be the result of a failure of the embryonic lining of the gullet to achieve maturity. Diagnosis depends primarily on the demonstration by esophagoscopy that the change in mucous membrane occurs at high levels since the symptoms or radiologic findings are not sufficiently characteristic.Benedict and Nardi,70 in a study of peptic stenosis of the esophagus, emphasize the importance of history and x-ray examination . . .
Pulmonary veno-occlusive disease
Authors: D. Montani, L. C. Price, P. Dorfmuller, L. Achouh, X. Jaïs, A. Yaïci, O. Sitbon, D. Musset, G. Simonneau, M. Humbert
Journal: European Respiratory Journal (2008)

Pulmonary veno-occlusive disease (PVOD) is currently classified as a subgroup of pulmonary arterial hypertension (PAH) and accounts for 5-10% of cases initially considered to be idiopathic PAH. PVOD has been described as idiopathic or complicating other conditions, including connective tissue diseases, HIV infection, bone marrow transplantation, sarcoidosis and pulmonary Langerhans cell granulomatosis. PVOD shares broadly similar clinical presentation, genetic background and haemodynamic characteristics with PAH. Compared to PAH, PVOD is characterised by a higher male/female ratio, higher tobacco exposure, lower arterial oxygen tension at rest, lower diffusing capacity of the lung for carbon monoxide, and lower oxygen saturation nadir during the 6-min walk test. High-resolution computed tomography (HRCT) of the chest can be suggestive of PVOD in the presence of centrilobular ground-glass opacities, septal lines and lymph node enlargement. Similarly, occult alveolar haemorrhage is associated with PVOD. A noninvasive diagnostic approach using HRCT of the chest, arterial blood gases, pulmonary function tests and bronchoalveolar lavage could be helpful for the detection of PVOD patients and in avoiding high-risk surgical lung biopsy for histological confirmation. PVOD is characterised by a poor prognosis and the possibility of developing severe pulmonary oedema with specific PAH therapy. Lung transplantation is the treatment of choice. Cautious use of specific PAH therapy can, however, be helpful in some patients.
History of Medical Practice in Illinois.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial Board
Authors: Jeffrey Bernhard, Thomas Cropley, Karen Wiss, Melissa Derby, Ponciano Cruz, John Digiovanna, Rhode Island, Jane Grant-Kels, Connecticut Dermatopathology, Nathaniel Jellinek, Timothy Johnson, Ann Arbor, Michigan Surgery, Marta Petersen, David Rubenstein, Chapel Hill, Martin Weinstock, Suddhasatta Acharyya, Leah Belazarian, Michael Bigby, Jean Bolognia, New Haven, Luis Diaz, Carolina Lebwohl, New York, Donald Miech, Wisconsin Ginat, W Mirowski, Scott Norton, Maryland Olsen, Carolina Orringer, Amy Paller, J Smith, Richard Dobson
Journal: Journal of the American Academy of Dermatology (2008)
Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in people with hereditary haemochromatosis
Authors: Stephan Buch, Aneesh Sharma, Eleanor Ryan, Christian Datz, William Griffiths, Michael Way, Thomas Buckley, Paola Dongiovanni, Jochen Zwerina, Uta Merle, Karl Heinz Weiss, Elmar Aigner, Christian Dejaco, Janett Fischer, Thomas Berg, Luca Valenti, Heinz Zoller, Andrew McQuillin, Jochen Hampe, Felix Stickel, Marsha Morgan
Journal: Journal of Hepatology (2020)
The Cultural Parameters of Lead Poisoning: A Medical Anthropologist's View of Intervention in Environmental Lead Exposure
Authors: Robert T. Trotter
Journal: Environmental Health Perspectives (1990)

This article identifies four culturally shaped sources of lead exposure in human societies: modern and historic technological sources: food habits; culturally defined health beliefs; and beauty practices. Examples of these potential sources of lead poisoning are presented from current cultures. They include the use of lead-glazed cooking pottery in Mexican-American households; folk medical use of lead in Hispanic, Arabic, South Asian, Chinese, and Hmong communities; as well as the use of lead as a cosmetic in the Near East, Southeast Asia, and South Asia. Four interacting cultural conditions that create barriers to the reduction of lead exposure and lead poisoning are identified and discussed. These are knowledge deficiencies, communication resistance, cultural reinterpretations, and incongruity of explanatory models.
"EXCLUSION OF ACTIVE MYCOBACTERIUM TUBERCULOSIS COMPLEX INFECTION WITH THE T-SPOTTM.TB ASSAY". R.M.L. VAN LEEUWEN, A.W.J. BOSSINK AND S.F.T. THIJSEN. EUR RESPIR J 2007; 29: 605-607.
Authors: K Mohammed, S Brown, Y Su, P Sriram, B Moudgil, R Loddenkemper
Journal: European Respiratory Journal (2007)

Unfortunately, a small section of text in the above paper (in the Discussion, paragraph four) was reported incorrectly.The sentence ''Apart from case B, who was suffering from disseminated M. tuberculosis complex infection, no patients described in the present report were likely to be immunocompromised.''should read ''Apart from case B, who was suffering from disseminated MOTT infection, no patients described in the present report were likely to be immunocompromised.''
Positive Test Results for Acute Hepatitis A Virus Infection Among Persons With No Recent History of Acute Hepatitis--United States, 2002-2004
Journal: JAMA (2005)

Hepatitis A is a nationally reportable condition, and the surveillance case definition includes both clinical criteria and serologic confirmation. State health departments and CDC have investigated persons with positive serologic tests for acute hepatitis A virus (HAV) infection (i.e., IgM anti-HAV) whose illness was not consistent with the clinical criteria of the hepatitis A case definition. Test results indicating acute HAV infection among persons who do not have clinical or epidemiologic features consistent with hepatitis A are a concern for state and local health departments because of the need to assess whether contacts need postexposure immunoprophylaxis. This report summarizes results of three such investigations, which suggested that most of the positive tests did not represent recent acute HAV infections. To improve the predictive value of a positive IgM anti-HAV test, clinicians should limit laboratory testing for acute HAV infection to persons with clinical findings typical of hepatitis A or to persons who have been exposed to settings where HAV transmission is suspected.
Missed Appointment
Authors: Brenda Butka
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vinorelbine (NVB)-carboplatin (CBDCA) vs non-platinum doublets in inoperable non-small cell lung cancer (NSCLC) patients (pts)-final results of the Glob 2 phase III with patient benefit analysis
Authors: R. P. Abratt, A. Szczesna, K. Mattson, M. Wernli, P. Reiterer, R. Hui, J. Lizon, O. Bertetto, M. Reck, E. H. Tan
Journal: Journal of Clinical Oncology (2004)

7016
CARDIORENAL CIRCULATORY CHANGES IN LIVER DECOMPENSATION
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The year past and the year ahead – some facts and figures about Eurosurveillance
Journal: Eurosurveillance (2016)

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Making medical errors into "medical treasures''
Authors: D. Blumenthal
Journal: JAMA (1994)

In his insightful and provocative article on medical error, Leape<sup>1</sup>raises a topic that has been distinctly unpopular among physicians. Concerning medical error and its prevention, the profession has, with rare exceptions, adopted an ostrichlike attitude. Mistakes have been treated as uncommon and atypical, requiring no remedy beyond the traditional incident reports and morbidity and mortality conferences. The manner in which physicians manage medical errors must and will change in the future. It will change because a large and growing collection of literature demonstrates that physicians' approaches to the management of medical error do not work well enough, and the various parties to which physicians are accountable—purchasers, payers, government, and the public—have discovered this fact. The only question now is whether new systems for preventing medical error will be designed with the full cooperation and participation of the profession or under less desirable circumstances. The See also p 1851.
ITALY
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Utilization of nonaccepted premedical students
Authors: C. B. Andrews
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The, EDITORIALS, "The Medical Manpower Shortage" and "Americans in Foreign Medical Schools" (<b>217</b>:1857, 1971), and the article, "Foreign Medical Schools" (<b>217</b>:1845, 1971), reveal an unexploited medical manpower pool of 14,000 "nonaccepted" medical students, 53.85% of the 26,000 applicants in 1971. Many of these disappointed, better-than-average third- and fourth-year university and college students warrant a chance to earn the right to become a physician. The field of opportunity is on the civilian medical firing line of perimeter medicine. Young physician replacements for the older primary physician are practically non-existent in these areas of greatest need. Present efforts to produce doctors and allied health personnel for the innumerable areas in need of adjunctive community medical care services for the ambulatory type of patients are of token proportions. Primary medical care is the focal point for early diagnosis coupled with adequate treatment to provide the foundation for prevention
The Heart and Its Diseases. A Handbook for Students and Practitioners.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inappropraite ADH Secretion in Chest Disease
Authors: W Harland
Journal: BMJ (1975)

need of constant vigilance to prevent it.The circular is intended for doctors, health officers, social workers, and commnunity nursing staff, and is being distributed from St. Andrew's House, Edinburgh. Advice on SmokingSo Now You Know About Smoking is the latest in the series of Family Doctor book- lets.Written by Dr.
CLINICAL STUDIES ON A NEW INFLUENZA VACCINE
Journal: JAMA (1941)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal