tbuckley/cabot-search huggingface dataset:
Molecular Dosimetry of DNA and Hemoglobin Adducts in Mice and Rats Exposed to Ethylene Oxide
Authors: Vernon E. Walker, Timothy R. Fennell, Patricia B. Upton, John P. MacNeela, James A. Swenberg
Journal: Environmental Health Perspectives (1993)

Experiments involving ethylene oxide (ETO) have been used to support the concept of using adducts in hemoglobin as a surrogate for DNA adducts in target tissues. The relationship between repeated exposures to ETO and the formation of N-(2-hydroxyethyl)valine (HEtVal) in hemoglobin and 7-(2-hydroxyethyl)guanine (7-HEG) in DNA was investigated in male rats and mice exposed by inhalation to 0, 3, 10, 33, or 100 ppm ETO for 6 hr/day for 4 weeks, or exposed to 100 ppm (mice) or 300 ppm (rats) for 1, 3, 5, 10, or 20 days (5 days/week). HEtVal was determined by Edman degradation, and 7-HEG was quantitated by HPLC separation and fluorescence detection. HEtVal formation was linear between 3 and 33 ppm ETO and increased in slope above 33 ppm. The dose-response curves for 7-HEG in rat tissues were linear between 10 and 100 ppm ETO and increased in slope above 100 ppm. In contrast, only exposures to 100 ppm ETO resulted in significant accumulation of 7-HEG in mice. Hemoglobin adducts were lost at a greater rate than predicted by normal erythrocyte life span. The loss of 7-HEG from DNA was both species and tissue dependent, with the adduct half-lives ranging from 2.9 to 5.8 days in rat tissues (brain, kidney, liver, lung, spleen, testis) and 1.0 to 2.3 days in all mouse tissues except kidney (t1/2 = 6.9 days). The concentrations of HEtVal were similar in concurrently exposed rats and mice, whereas DNA from rats had at least 2-fold greater concentrations of 7-HEG than DNA from mice.(ABSTRACT TRUNCATED AT 250 WORDS)
Imported Seabass as a Source of Mercury Exposure: A Wisconsin Case Study
Authors: Lynda M. Knobeloch, Meg Ziarnik, Henry A. Anderson, Vernon N. Dodson
Journal: Environmental Health Perspectives (1995)

The Wisconsin Division of Health investigated mercury exposure in a 40-year-old man, his 42-year-old wife, and their 2.5-year-old son. At the time of our investigation, these individuals had blood mercury levels ranging from 37 to 58 micrograms/L (normal < 5 micrograms/L) and hair samples from the adults contained 10-12 micrograms mercury/g dry weight. A personal interview and home inspection failed to identify any occupational or household sources of mercury exposure. The family's diet included three to four fish meals per week. The fish was purchased from a local market and included Lake Superior whitefish, Lake Superior trout, farm-raised trout and salmon, and imported seabass. Analysis of these fish found that only one species, the imported seabass, contained significant mercury levels. Two samples of the seabass obtained from the vendor on different days contained mercury concentrations of 0.5 and 0.7 mg/kg. Based on consumption estimates, the average daily mercury intakes for these individuals ranged from 0.5 to 0.8 micrograms/kg body weight. Six months after the family stopped consuming the seabass, blood mercury levels in this man and woman were 5 and 3 micrograms/L, respectively. Analysis of sequential blood samples confirmed that mercury elimination followed first-order kinetics with a half-life of approximately 60 days.
HIV infection, pregnant women, and newborns. A policy proposal for information and testing. Working Group on HIV Testing of Pregnant Women and Newborns
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dysgerminoma
Authors: Raúl G. Reyes
Journal: JAMA (1960)

Dysgerminomas are relatively rare malignant tumors of the ovary and testis. Present and past usage of the term has been, unfortunately, limited to the tumors in the female, where they occur predominantly in the young. They comprise 3% of all ovarian malignancies, and 72% occur in the second and third decades.<sup>1</sup>A high percentage of sexual underdevelopment, sterility, and hermaphroditism in association with these tumors has been reported.<sup>2</sup>In most cases hormonal indifference is present although occasionally A-Z titers have been reported to be high.<sup>3</sup>The first symptom is usually awareness of an abdominal mass, the tumors achieving huge proportions. Metastases are primarily regional but can and do occur to distant sites. The five-year cure rate following therapeutic measures has been variously estimated at 27 to 67%.<sup>4</sup> Chevassu<sup>5</sup>in 1906 was the first one to call to the attention of the medical world the presence
Miscellanea Medica
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conditioning Techniques
Authors: A. H. Crisp
Journal: BMJ (1966)

<b>OBJECTIVE</b>: To assess the predictive ability of various aspects of the work environment for organizational commitment. <b>METHODS</b>: A questionnaire measuring three dimensions of organizational commitment along with five aspects of work environment and 10 demographic and work setting characteristics was sent to a national, convenience sample of clinical laboratory professionals. <b>SETTING AND PARTICIPANTS</b>: All persons obtaining the CLS certification by NCA from January 1, 1997 to December 31, 2006. Only respondents who worked full-time in a clinical laboratory setting were included in the database. <b>MAIN OUTCOME MEASURES</b>: Levels of affective, normative, and continuance organizational commitment, organizational support, role clarity, role conflict, transformational leadership behavior of supervisor, and organizational type, total years work experience in clinical laboratories, and educational level of respondents. Questionnaire items used either a 7-point or 5-point Likert response scale. <b>RESULTS</b>: Based on multiple regression analysis for the 427 respondents, organizational support and transformational leadership behavior were found to be significant positive predictors of affective and normative organizational commitment. Work setting (non-hospital laboratory) and total years of work experience in clinical laboratories were found to be significant positive predictors of continuance organizational commitment. Overall the organizational commitment levels for all three dimensions were at the neutral rating or below in the slightly disagree range. <b>CONCLUSIONS</b>: The results indicate a less than optimal level of organizational commitment to employers, which were predominantly hospitals, by CLS practitioners. This may result in continuing retention problems for hospital laboratories. The results offer strategies for improving organizational commitment via the significant predictors. <b>ABBREVIATIONS</b>: ASCP = American Society for Clinical Pathology; CLS= clinical laboratory scientist as certified by NCA; MT = medical technologist as certified by ASCP; NCA=National Credentialing Agency for Laboratory Personnel; RT(R) = registered radiologic technologist as certified by the American Registry of Radiologic Technologists.
Effects of Cadmium Ingestion in Rats with Opposite Genetic Predisposition to Hypertension
Authors: Edward V. Ohanian, Junichi Iwai
Journal: Environmental Health Perspectives (1979)

This study was undertaken to explore the effects of chronic low-level cadmium ingestion in Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats. Groups of weanling female R and S rats were given 0 or 1 mg cadmium/1. in drinking water and fed either a low salt (0.4% NaCl) or a high salt (4% NaCl) diet for 28 weeks. Cadmium produced hypertension associated with gross cardiac hypertrophy and mild to moderate renal vascular changes in S, but not in R, rats on a low salt diet. Cadmium enhanced the rate and degree of development of salt-induced hypertension without exacerbating the hypercholesterolemia or renal vascular lesions normally observed in S rats on a high salt diet. Cadmium lowered circulating cholesterol levels in both lines on a low salt diet. Cadmium had no influence on growth, blood urea nitrogen concentration, plasma renin activity, tumor formation, or survivorship in R and S rats on either salt diet. This study indicates that the genetic composition is a critical determinant of the adverse effects of chronic low-level cadmium ingestion in rats. In addition to the experimental implications, these findings may have relevance to the problem of human "essential" hypertension.
Injuries of the sporting knee
Authors: I Corry, J Webb
Journal: British Journal of Sports Medicine (2000)

Surgeon at the Royal London Hospital.He has been active for many years in BASEM management and in postgraduate sports medicine education.His special interest is knee surgery and he has published several papers on the subject of jumper's knee and other lesions of the patellar tendon.This review is in two sections covering patellar dislocation and patellar tendinopathy.Anterior knee pain and patellar fractures were not part of the author's brief for the article, while lesions of articular cartilage are to be included in the next paper in the series.There is current interest in the medial patellofemoral ligament and the potential for its reconstruction as a major restraint in preventing lateral displacement. 1This will become a topical consideration alongside the techniques described in the review.The role of the impinging lower pole of the patella in patellar tendinosis is another topical subject under consideration and mentioned in the review.Such concepts appeal to the orthopaedic surgeon because they give mechanical clues to the cause and, by implication, the surgical treatment in these conditions.In practice, the treatments should always be conservative if possible; however, functional deficiency, implying functional rehabilitation as treatment, is much more difficult to quantify.Until our evidence base for treatment is more than just empirical, there is an important message in the article urging treatment of the patient rather than the imaging appearance.
Viral hepatitis in Belgian prisons: a first-time multicenter prevalence study
Authors: Dana Busschots, Rob Bielen, Özgür Koc, Eefje Dercon, Christian Brixko, Pierre Laukens, Pascal Bilaey, Francis De Smet, Geert Hellemans, Gaetan Muyldermans, Luc Van Baelen, Hans Van Vlierberghe, Geert Robaeys
Journal: Journal of Hepatology (2020)
Silent ischemia on Holter monitoring predicts mortality in high-risk postinfarction patients
Authors: S. O. Gottlieb
Journal: JAMA (1988)

The relative prognostic significance of ischemic ST changes on two-lead continuous electrocardiographic (Holter) monitoring in 103 high-risk postinfarction patients was examined. Ischemic ST changes were detected in 30 patients, with a median number of five episodes per day and median total daily duration of 157 minutes. Only one third of these patients reported any angina in the hospital, and 28 of the 30 patients had silent ST changes on Holter monitoring. The remaining 73 patients had no ischemic ST changes on Holter monitoring. At one year, nine (30%) of 30 patients with ischemic ST changes were dead vs only eight (11%) of 73 patients without such changes. Multivariate Cox's hazard function analysis on 18 variables, including age, type of infarction, Lown and Killip class, ejection fraction, and medications, showed that the presence of ST changes on Holter monitoring was a significant predictive variable for one-year mortality in the overall study population and particularly in the subgroup of 59 patients who could not undergo early exercise treadmill testing. Thus, ischemic ST changes on Holter monitoring, the majority of which are silent, occur in nearly one third of high-risk postinfarction patients and are significantly associated with one-year mortality. (<i>JAMA</i>1988;259:1030-1035)
Abstract 4558: Mapping tolerized T cell states to exhaustion phenotypes in NSCLC
Authors: Edgar Kozlova, Shingo Eikawa, Sacha Gnjatic, Bojan Losic
Journal: Cancer Research (2019)

Abstract The promise of checkpoint blockade treatment has yet to be fully realized in part due to a lack of knowledge of immune exhaustion and its efficient characterization, especially in the context of immunosuppressive tumor microenvironments which effectively tolerize the immune system. We hypothesized that mapping expression signatures defining regulatory T-cell states to previously studied and characterized exhaustion phenotypes of infiltrating T cells in NSCLC would reveal points of contact between T cell tolerization and exhaustion. Concretely, we profiled the gene expression and directly inferred CDR3/1 clonality between tolerized and immunized states in purified CD4+ T-Cells from 10 patients with ovarian or peritoneal and non-small cell lung cancer. The samples were taken before and during immunization therapy for the antigens MAGE-A3 or NY-ESO-1 over a period of 13 weeks, in the presence and absence of adjuvant to emulate the tolerized and immunized states. Further, by modeling the regulatory T-cell states as an interaction between the tolerized and immunized with time and type of antigen allowed us to identify significant differentially expressed gene clusters and their correlation to clonality. We then projected these signatures onto single cell RNAseq data from NSCLC-TCGA to compare the identified clusters to previously identified exhaustion phenotypes. We show that antigen vaccination is immunostimulating and induces lymphocyte activation, leading to a proinflammatory environment. During an immunized stated an increase in cytokine activity, including IL2, 4, 9, 10, 13 and 17, whereas tolerized T Cells, we observe an increase in clonality, BIRC6 and IL20 apart from alterations in chromosome organization pathways and cell cycle including senescence. In conclusion, we detail how the differences between tolerized and immunized states help unravel exhaustion mechanisms, which will ultimately identify molecular markers for exhaustion to assist during treatment and prognosis in clinical settings. Citation Format: Edgar Kozlova, Shingo Eikawa, Sacha Gnjatic, Bojan Losic. Mapping tolerized T cell states to exhaustion phenotypes in NSCLC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4558.
The Cover
Authors: Clinton A. Roath
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Importation of Cholera From Peru
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predicting Suicide
Authors: Dan C. Bird
Journal: Annals of Internal Medicine (1991)

Letters15 January 1991Predicting SuicideDan C. Bird, MDDan C. Bird, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-2-168_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Annals recently published an editorial by Lowensteinand Hunt (1) on injury. Most of what they say seems reasonable except in their discussion of suicide. The authors state that they believe that screening for a "suicide intent" ought to be done. It is fine to mention such things, and they have been mentioned to me since I was a house officer 25 years ago. To date, I have never, ever had any guidelines on how to predict suicide, what to look for, or how to certify that a certain person is unlikely to commit suicide.At present, Lowenstein...Reference1. LowensteinHunt SD. Injury prevention in primary care. Ann Intern Med. 1990;113:261-3. LinkGoogle Scholar1. LowensteinHunt SD. Injury prevention in primary care. Ann Intern Med. 1990;113:261-3. LinkGoogle Scholar2. Murphy G. On suicide prediction and prevention. Arch Gen Psychiat. 1983;40:343-4. CrossrefMedlineGoogle Scholar3. WellsStewartHays KAR. The functioning and well-being of depressed patients. Results from the medical outcomes study. JAMA. 1989;262:914-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 4911 Van Nuys Boulevard, Suite 301 Sherman Oaks, CA 91403 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1991Volume 114, Issue 2Page: 168-169KeywordsSuicide Issue Published: 15 January 1991 PDF DownloadLoading ...
Peptic Ulcer: Clinical Roentgenology, with Case Histories.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contamination of the Bay of Fundy-Gulf of Maine Area with Polychlorinated Biphenyls, Polychlorinated Terphenyls, Chlorinated Dibenzodioxins, and Dibenzofurans
Authors: V. Zitko, O. Hutzinger, P. M. K. Choi
Journal: Environmental Health Perspectives (1972)

The procedure used to determine polychlorina- ted biphenyls (PCBs), polychlorinated terphenyls (PCTs), chlorinated dibenzodioxins, and chlori- nated dibenzofurans is outlined in Table 1.It is based on the cleanup-chromatography of Holden and Marsden (1), modified as described (2).Most PCBs are eluted in fraction I. Fraction II contains some PCBs, p , p'-DDE, and PCTs, whereas hepta- chlor exposide, dieldrin, endrin, p,p'-DDD, and p , p'-DDT are eluted in fraction III.Fractions I and II are further chromatographed on alumina, essentially according to Porter and Burke (3), to determine chlorinated dibenzodioxins and dibenzo- furans.PCTs, hexaand octachlorodibenzodioxin, and octachlorodibenzofuran were quantified by gas chromatography on 3% OV-210 on Chromosorb WAW 60/80 in a 6 ft X 4 mm column at 200°C.A 4% SE-30 column was used to quantify PCBs, chlorinated hydrocarbon pesticides, 2,3,7, 8-tetra- chlorodibenzodioxin, di-, tri-, and tetrachlorodibenzofuran.Recovery of PCBs and chlorinated hydrocarbon