tbuckley/cabot-search huggingface dataset:
* Genetic variation in natural killer cell receptor protein G2D does not modify susceptibility to sporadic cholangiocarcinoma
Authors: C. A. Wadsworth, P. H. Dixon, A. A. Zabron, J. H. Wong, M. H. Chapman, S. C. McKay, D. R. Spalding, S. P. Pereira, H. S. Wasan, H. C. Thomas, S. D. Taylor-Robinson, J. C. Whittaker, C. Williamson, S. A. Khan
Journal: Gut (2011)

<h3>Background</h3> Advances in understanding the pathogenesis of RA support the contribution of T cells in the disease process through the recognition of the arthritogenic antigen (Ag) and maintenance of chronic inflammatory response [1]. Previous gene association studies have demonstrated that CD247 gene expressions are associated with a variety of autoimmune disease. As regard Rheumatoid Arthritis (RA), this relationship has not been fully clarified yet. <h3>Objectives</h3> We aimed to evaluate the T-cell receptor-CD3 zeta chain (<i>TCR-CD3</i> ζ) gene expression profile in a cohort of patients with RA. <h3>Methods</h3> A case-control study on 150 consecutive RA patients diagnosed according to 2010 ACR/EULAR criteria and 150 matched healthy controls without family history of RA or other autoimmune diseases. RA patients with other autoimmune diseases, viral hepatitis B or C, malignancy or hematological disorders were excluded from the study. All participants were subjected to history taking, clinical examination, assessment of disease activity (in RA patients) using DAS-28 and HAQ, routine laboratory investigations, inflammatory markers level, serological tests, as well as molecular analysis for <i>TCR-CD3ζ</i> mRNA expression by quantitative real-time polymerase chain reaction. <h3>Results</h3> <i>TCR-CD3ζ</i> gene expression was significantly lower in RA cases than in healthy controls (p&lt;0.05)<i> (Table 1)</i>. Expression of <i>TCR-CD3ζ</i><b>revealed</b> a significant negative correlation with RA disease duration, RF, and ESR (p&lt;0.05) in RA cases. The level of<b><i>TCR-CD3ζ</i> also showed a significant lower expression in +ve RF patients than in –ve RF patients (p&lt;0.05). The AUC of <i>TCR-CD3ζ</i> level showed a moderate level of accuracy (AUC = 0.840, p=0.025) (<i>Figure 1),</i> and the calculated cutoff value (≤ 0.077) can precisely discriminate subjects with RA from those without RA with 93.5% sensitivity and 75% specificity(<i>Table 2</i>).</b> <h3>Conclusion</h3> Our results demonstrated a lower expression of TCR-CD3ζ in RA patients than in healthy controls. We suggested that CD247 gene down-regulation might contribute in the susceptibility to RA and help understanding the mechanisms responsible for deficient T-cell responses in RA patients. <h3>Reference</h3> [1] Wfeyand CM, Gaoronzy JJ. Pathogenesis of rheumatoid arthritis. Med Clin North Am 1997; 81:29–55. <h3>Disclosure of Interests</h3> None declared
RIO DE JANIERO
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Highlights
Journal: JAMA Oncology (2018)

Postoophorectomy Hormone Therapy in BRCA1 Carriers 1059Hormone therapy (HT) is prescribed for women to control symptoms of menopause but is limited for use in breast cancer due to fear of stimulating tumor growth.Kotsopoulos et al questioned whether BRCA1 mutation carriers would be harmed by HT use.This prospective, longitudinal cohort study of 872 BRCA1 mutation carriers who underwent bilateral oophorectomy surveyed women about HT use.Overall, HT use after oophorectomy was not associated with an increased risk of breast cancer.These data suggest that HT might be used safely in this population. Cost-effectiveness of Osimertinib in Advanced Lung Cancer 1080Osimertinib is a potent, irreversible, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that blocks both the common EGFR-activating mutations and the T790M mutation.The FLAURA trial compared osimertinib with first-generation EGFR-TKIs in treatment-naive patients with advanced non-small cell lung cancer and EGFR mutation and found that progression-free survival was superior with osimertinib.Is moving osimertinib to frontline therapy cost-effective?Aguiar et al extracted patient data from the FLAURA trial to compare the cost-effectiveness of osimertinib with first-and second-generation EGFR TKIs over 10 years.They found that at current costs, osimertinib is not cost-effective for first-line therapy of EGFR-mutated NSCLC.
THE FREE MEDICAL AND SURGICAL TREATMENT OF THE WELL-TO-DO IN MICHIGAN UNIVERSITY.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract A21: Hypoxia preconditioning affects metastatic seeding and proliferation through vascular and immune function, in a process regulated by lung endothelial HIFa
Authors: Cristina Branco, Helene Rundqvist, Renato Colaco, Randall S. Johnson
Journal: Cancer Research (2016)

Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR03) of the Conference Proceedings. Citation Format: Cristina Branco, Helene Rundqvist, Renato Colaco, Randall S. Johnson. Hypoxia preconditioning affects metastatic seeding and proliferation through vascular and immune function, in a process regulated by lung endothelial HIFa. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr A21.
Hepatitis B surface antigenemia in renal transplant recipients. Increased mortality risk
Authors: W. D. Hillis
Journal: JAMA (1979)

To determine effects of circulating hepatitis B surface antigen (HBsAg) on patient survival following renal transplantation, we studied 168 recipients of cadaveric grafts in whom HBsAg status was defined at transplantation by comparison of survivorships determined by actuarial life-table methods. Survival in HBsAg-positive recipients, as compared with those who were HBsAg-negative at the time of transplantation, was markedly diminished. Although graft survival appeared to be favored in the HBsAg-positive group in the early posttransplant period, the apparent protective effect was lost at nine months after grafting and thereafter, due to increased mortality in the HBsAg-positive recipients. Deaths in the antigenemic subjects were principally due to infections other than hepatitis and to cardiovascular events. We conclude that preexisting HBs antigenemia forebodes an ominous outcome for immunosuppressed renal transplant recipients, although hepatic disorders do not account for most deaths. (<i>JAMA</i>242:329-332, 1979)
In vitro Approaches for Determining Mechanisms of Toxicity and Carcinogenicity by Asbestos in the Gastrointestinal and Respiratory Tracts
Authors: Brooke T. Mossman
Journal: Environmental Health Perspectives (1983)

Organ and cell cultures of gastrointestinal and tracheobronchial epithelium have been used to document both the interaction of asbestos with mucosal cells and the sequence of cellular events occurring after exposure of cells to fibers. The biological activity of various types of asbestos in vitro is related to surface charge, crystallization, and dimensional characteristics. These factors also influence adsorption of natural secretions and serum components to fibers, a process that ameliorates cytotoxicity. Although mechanistic studies at the cellular level are lacking using epithelial cells of the digestive tract, asbestos appears to elicit a constellation of morphologic and biochemical changes in tracheal epithelium that resemble effects of classical tumor promoters on target cells.
PHOSPHORUS POISONING IN THE MATCH INDUSTRY IN THE UNITED STATES
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Equipment Design Issues for the In Vivo X-Ray Fluorescence Analysis of Bone Lead
Authors: Brian J. Thomas
Journal: Environmental Health Perspectives (1991)

Several groups have reported the development of systems, based on the principle of X-ray fluorescence, for the in vivo measurement of bone lead concentrations. These systems have used the detection of either the characteristic L or K X-rays resulting from excitation by a suitable photon source. This paper examines design issues related to the development of these systems. These design issues are, in most instances, a result of consideration of the physical principles involved, and hence there are many features common to the systems developed by the individual groups. Design issues discussed in this paper include the selection of the site for measurement, source-sample-detector configuration, and collimation. Specific examples from published work are used to demonstrate the relevant features.
Massachusetts Medical Society
Authors: Lamar Soutter
Journal: New England Journal of Medicine (1978)

Synopsis of Council Meeting March 22, 1978The Council met at the Park Plaza Hotel, Boston, on March 22, 1978 at 10:10 a.m. There were 218 councilors in attendance. The minutes of the meeting of the Executive Board on January 11, 1978, were accepted.The following informational reports were filed: Committee on Drugs and Therapeutics, Committee on Emergency Medical Services, Committee on Ethics and Discipline, Committee on Legislation, Committee on Long Range Planning, Committee on Medical Education, Committee on Medical Services, Committee on Nominations, Committee on Occupational Health, Committee on Student Health, Committee on Television Violence, Committee on Prevention of . . .
Leitfaden der neurologischen Diagnostik. Eine Differential-diagnose aus dem führenden Symptom für praktische Aerzte und Studierende.
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Errors in Text
Journal: JAMA Neurology (2017)

Yong-Won Shin, MD; Kyung-Il Park, MD, PhD; Jangsup Moon, MD, PhD; Soon-Tae Lee, MD, PhD; Kon Chu, MD, PhD; Sang Kun Lee, MD, PhD; Jae-Kyu Roh, MD, PhD; Keun-Hwa Jung, MD, PhD
2C: Pathophysiological aspects of H. pylori infections
Authors: B Schenk ', E Kuipers, E Klinkenberg-Knol, E Bloemena', G Nelis, H Festen, C Lamers, S Meuwissen, J Stachura, J Konturek, E Karczewska, W Domschke, S Konturek, V Warburton ', S Everett, N Mapstone, A Axon, P Hawkey ', M Dixon '. ', S Rosenstock, N Milman, L Andersen, I Bonnevie, T J0rgensen, B Tillenburg, U Peitz, G Borsch, M Stolte, J Labenz, J.-P Idstrom, E Verdd, G Bbrsch, A Blum
Journal: Gut (1996)

Infection with Helicobacter pylori (Hp) and treatment with profound acid suppressive drugs are two unrelated conditions associated with mild hypergastrinemia (HG).During treatment with omeprazole, some patients however develop severe HG (> 400 ng/l) and ECL hyperplasia.The cause of these extreme gastrin levels is unknown.One hypothesis is that they are associated with Hp infection and atrophic gastritis.Other explanations include vagal nerve dysfunction and delayed gastric emptying.We studied 26 GERD patients (pts) treated with maintenance PPI; 13 with severe hypergastrinemia (8 M, mean age: 66 yrs, range 50-75) and 13 controls (10 M, age: 60 yrs, 49-72).Mean baseline serum gastrin ± SEM was 1381 236 vs. 186 ± 32 ngfl (p < 0.001).Pretreatment gastrin levels were normal (< 100 ng/l) in all 26 subjects.Methods: Hp infection was assessed by serology and histology.Delayed gastric emptying was determined by endoscopical scoring of food remnants 12 hours after a standard meal.All subjects underwent a meal-stimulated gastrin test (SGT).Vagal nerve function was assessed by a pancreas polypeptide test (PPT) in HG pts.Results: 9/13 HG pts vs. 2/13 controls were infected with Hp (p < 0.02, Mann Whitney U-test).Atrophy of corpus occurred more often in HG's (8/13) than in controls (2/13; p = 0.05) and was in 9/10 cases associated with Hp infection (p < 0.05).Food retention was observed in 2/12 HG pts (vs.0/12; p = n.s.) PPT response showed no difference between HG pts (APP: 115 pmol/l (n = 9) vs. controls 140 (n = 8) (p = 0.09).Response on SGT was, although within normal limits in both groups, diminished in HG pts (AMean i SEM: 98 4 16% vs. 187 i 26%, p = 0.01).Conclusion: Development of hypergastrinemia during omeprazole therapy is associated with Hp infection and induced atrophic gastritis.No correlation was found with stomach emptying or vagal nerve function as measured by the PPT.Antral G-cel response on SGT was diminished in the group with severe hypergastrinemia.
Dental asaesthesia.
Authors: J. G. Bourne
Journal: BMJ (1968)

MEDICALJOTUNAlthe rat uterus, but when given after isoprenaline the action is reversed and the uterus contracts.2It may be supposed that in a severe attack of asthma the patient is alarmed and is secreting adrenaline which would normally relax the bronchioles; if an excess of isoprenaline has been taken the effect of adrenaline will be reversed, leading to bronchoconstriction, and making death more likely.The prolonged use of isoprenaline might therefore defeat its own ends.It is not known what effects corticosteroids have on the action of catecholamines.Research on all these questions is urgently needed.
THU0506 Higher Proportions of Pathogenic Ccr6+ T Cell Subpopulations in Acpa+ Compared to ACPA- Patients with Early Rheumatoid Arthritis
Authors: S.M. Paulissen, J.P. van Hamburg, N. Davelaar, H. Vroman, J.M. Hazes, P.H. de Jong, E. Lubberts
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Presence of serum anti-citrullinated protein antibodies (ACPAs) in patients with rheumatoid arthritis (RA) predicts worse disease course and a more erosive disease. In the pathogenesis of RA, inflammatory T cells play a central role. In this context, we recently found increased proportions of pathogenic peripheral CCR6+ memory T helper cells in patients with early RA compared to healthy individuals. However, it is unclear how T cell proportions are distributed between ACPA+ and ACPA- patients. <h3>Objectives</h3> Alterations in peripheral T cell populations and their pathogenic potential were examined in ACPA+ and ACPA- patient groups. <h3>Methods</h3> A nested matched case control study was performed including 27 ACPA+ and 27 ACPA- patients with early RA. T cell profiles (Treg, Th1, Th2, Th17, Th22 and various less well classified populations) from these ACPA+ and ACPA- patients were generated based on chemokine receptor, cytokine and transcription factor expression. Differentially present T cell populations were isolated from peripheral blood and analyzed for their pathologic potential in a co-culture system with RA derived synovial fibroblasts (RASF). <h3>Results</h3> In comparison to ACPA- patients, ACPA+ patients have higher proportions of regulatory T cells (Treg) and CD4+ memory CCR6+ T cells. Since the CCR6+ T cell population is still a heterogeneous population, four CCR6+ T cell subpopulations were distinguished by differential expression of CXCR3 and CCR4. All four CCR6+ subpopulations shared Th17 cell characteristics such as Rorγt and CCL20 expression, but IL-17A, IL-17F, IL-22 and IFN-γ expression differed greatly between these subpopulations. However, even the population with lowest expression of these cytokines showed high pathological potential as shown by stimulating IL-1β, IL-6, IL-8, COX-2 and MMP-3 expression upon co-culture with RASF. Indeed, despite dissimilar Th17 and Th1 characteristics between the CCR6+ subpopulations, all four showed highly increased pathological potential in co-culture compared to naive and T-helper-1 cells. <h3>Conclusions</h3> ACPA+ and ACPA- patients can be distinguished by the distribution of Treg and CCR6+ T cell subpopulations. These CCR6+ subpopulations exhibit dissimilar T-helper-17 and T-helper-1 characteristics, but all possess high pathological potential, including the population that has low IL-17A/F and IL-22 expression. These findings indicate a prominent role of CCR6+ T cells in the pathogenesis of ACPA+ patients with early RA and may contribute to the worse disease outcome in ACPA+ patients. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4287
Members House of of the Delegates
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New Sources Add to Lead Poisoning Concerns
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal