tbuckley/cabot-search huggingface dataset:
THIS WEEK
Authors: Rhona MacDonald
Journal: BMJ (2004)

CD8<sup>+</sup> T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A recently identified subpopulation of memory CD8<sup>+</sup> T cells, named tissue-resident memory T (T<sub>RM</sub>)&nbsp;cells, persists in peripheral tissues and does not recirculate. This T-cell subset is considered an independent memory T-cell lineage with a specific profile of transcription factors, including Runx3<sup>+</sup>, Notch<sup>+</sup>, Hobit<sup>+</sup>, Blimp1<sup>+</sup>, BATF<sup>+</sup>, AHR<sup>+</sup>, EOMES<sup>neg</sup> and Tbet<sup>low</sup>. It is defined by expression of CD103 (α<sub>E</sub>(CD103)β<sub>7</sub>) and CD49a (VLA-1 or α<sub>1</sub>β<sub>1</sub>) integrins and C-type lectin CD69, which are most likely involved in retention of T<sub>RM</sub> cells in non-lymphoid tissues, including solid tumors. CD103 binds to the epithelial cell marker E-cadherin, thereby favoring the location and retention of T<sub>RM</sub> in epithelial tumor regions in close contact with malignant cells. The CD103-E-cadherin interaction is required for polarized exocytosis of lytic granules, in particular, when ICAM-1 expression on cancer cells is missing, leading to target cell death. T<sub>RM</sub> cells also express high levels of granzyme B, IFNγ and TNFα, supporting their cytotoxic features. Moreover, the local route of immunization targeting tissue dendritic cells (DC), and the presence of environmental factors (i.e. TGF-β, IL-33 and IL-15), promote differentiation of this T-cell subtype. In both spontaneous tumor models and engrafted tumors, natural T<sub>RM</sub> cells or cancer-vaccine-induced T<sub>RM</sub> directly control tumor growth. In line with these results, T<sub>RM</sub> infiltration into various human cancers, including lung cancer, are correlated with better clinical outcome in both univariate and multivariate analyses independently of CD8<sup>+</sup> T cells. T<sub>RM</sub> cells also predominantly express checkpoint receptors such as PD-1, CTLA-4 and Tim-3. Blockade of PD-1 with neutralizing antibodies on T<sub>RM</sub> cells isolated from human lung cancer promotes cytolytic activity toward autologous tumor cells<i>.</i> Thus, T<sub>RM</sub> cells appear to represent important components in tumor immune surveillance. Their induction by cancer vaccines or other immunotherapeutic approaches may be critical for the success of these treatments. Several arguments, such as their close contact with tumor cells, dominant expression of checkpoint receptors and their recognition of cancer cells, strongly suggest that they may be involved in the success of immune checkpoint inhibitors in various cancers.
"MYOCARDOSIS"
Authors: Louis H. Sigler
Journal: JAMA (1930)

<h3>To the Editor:</h3> —InThe Journal, May 24, there appeared an article entitled "Myocardosis," by Drs. Albert S. Hyman and Aaron E. Parsonnet. This article attracted my attention because, about two years ago, I thought of using that term to designate a certain group of anatomicopathologic states of the heart characterized by acute or subacute degenerative processes, such as granular, hyaline and fatty degeneration, caused, occasionally, by constitutional infections or intoxication. Such a term offers a correct classification of this group as distinguished from acute, subacute and chronic inflammatory processes, and from fibrotic degeneration of the myocardium. Moreover, it corresponds exactly pathologically to the true meaning of nephrosis from which the authors draw their analogy, as used in degenerative nephropathies according to the following classification of Fahr: Simple nephrosis: First stage: albuminous degeneration. Second stage: hyaline degeneration. Third stage: necrosis (mercury poisoning). Distinctly characterized nephrosis: Lipoid nephrosis.
Western diet induced nuclear NFATC1 activates pro-apoptotic endoplasmic reticulum (ER) stress signaling, and progresses NAFLD to NASH
Authors: Muhammad Umair Latif, Kristina Reutlinger, Geske Schmidt, Sercan Mercan, Julia Kitz, Raza-Ur Rahman, Shiv Kumar Singh, Philipp Ströbel, Volker Ellenrieder
Journal: Journal of Hepatology (2020)
Biochemical Studies of Subretinal Fluid
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
My Dream
Authors: Joy E. Matthews
Journal: JAMA (1987)

I am downstairs watching television with my brothers when my father enters and hands me a stack of articles he has saved for me. It is not an uncommon occurrence: he has been saving medical journal articles for me for the past four years. He has even saved some of his medical school textbooks for me. You see, I am going to be a doctor. I know that sounds a bit conceited coming with such confidence from the mouth of a 17-year-old high school graduate who looks about 14 years old, but I did not choose my future profession: it chose me. I never decided to become a doctor. I always just knew I would become one. As I read this fresh batch of articles, however, my confidence dims a bit. Most of the articles my father brings me are "A Piece of My Mind" from<i>JAMA</i>, and with few
Angiograms of Intracranial Lesions From Trauma Reviewed
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cost containment and coronary artery surgery
Authors: R. H. Egdahl
Journal: JAMA (1983)

Loop and co-workers, in this issue ofThe Journal(p 63), describe studies in which they have been able to achieve major savings for patients undergoing coronary artery bypass graft (CABG) by a reassessment of the entire operative experience. By carrying out workups on an outpatient basis and admitting patients on the day of surgery, by decreasing special care unit time by one day, by not performing routine blood cross-match, and by not using preoperative Swan-Ganz catheters in uncomplicated cases, they have documented unit cost savings for their patients. By contrasting the group of Cleveland Clinic patients who were admitted on the day of surgery with another group with the usual two preoperative days in the hospital, they show that at least $1,000 per case has been saved in 1977 constant dollars. This work confirms and extends the 1979 study of Tomatis et al,<sup>1</sup>who demonstrated for CABG in
Phase 3 randomized, double-blind, controlled study of cabozantinib (XL184) versus placebo in subjects with hepatocellular carcinoma who have received prior sorafenib (CELESTIAL; NCT01908426).
Authors: Ghassan K. Abou-Alfa, Ann-Lii Cheng, Tim Meyer, Anthony B. El-Khoueiry, Masafumi Ikeda, Hoo Geun Chun, Sandrine J. Faivre, Junji Furuse, Jennifer J. Knox, Takuji Okusaka, Jerry Ping, Anne E. Borgman-Hagey, Robin Kate Kelley
Journal: Journal of Clinical Oncology (2014)

TPS4150 Background: Currently, there are no approved systemic therapies for patients with advanced hepatocellular carcinoma (HCC) who fail sorafenib. Cabozantinib is an oral receptor tyrosine kinase inhibitor (TKI) with activity against tyrosine kinases including MET, RET and VEGFRs. MET and VEGFR signaling have been implicated in tumor neo-angiogenesis and invasion. MET is overexpressed in HCC compared with non-tumor liver tissue, with higher MET expression linked to poor prognosis. Cabozantinib prolonged survival in a MET-driven transgenic mouse model of HCC, and has demonstrated clinical activity in multiple solid tumor types, including 41 subjects with advanced HCC treated in a phase 2 randomized discontinuation study. Methods: This phase 3, randomized, double-blind study evaluates the efficacy and safety of cabozantinib compared with placebo in subjects with advanced HCC previously treated with sorafenib and have progressed following 1-2 prior systemic treatments for HCC. Subjects must be ≥ 18 year old, have Child-Pugh Score of A and ECOG PS ≤ 1. Subjects are randomized 2:1 to receive either cabozantinib or placebo. Stratification factors are etiology of disease, geographic region and the presence of extrahepatic spread of disease and/or macrovascular invasion. The primary endpoint is overall survival. Secondary endpoints are progression-free survival and objective response rate by RECIST 1.1. Additional endpoints include safety, tolerability, circulating tumor cells, serum bone markers and plasma biomarkers, effects on bony disease assessed by bone scan and health-related quality of life (HRQoL) using the EuroQol Health questionnaire (EQ-5D-5L). Enrollment was initiated in September 2013. Target recruitment is 760 subjects. A total of 621 events planned with 2 interim analyses (at 311 and 466 events) would provide 90% power to detect a 31.6% increase in OS (HR=0.76). Clinical trial information: NCT01908426.
Physicians and their patients' suicides
Authors: J. S. Grisolia
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect on Blood Pressure of Putting Large Doses of Adrenaline into the Airways
Journal: Annals of Internal Medicine (2000)

Summaries for Patients16 May 2000The Effect on Blood Pressure of Putting Large Doses of Adrenaline into the AirwaysSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-10-200005160-00040 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Adrenaline, a naturally occurring hormone that raises blood pressure, is used as part of the standard cardiopulmonary resuscitation (CPR) protocol. Adrenaline is usually given through an intravenous catheter, a small tube that is put into a vein. When an intravenous catheter is not available, experts have suggested putting large doses of adrenaline into the bronchial tubes (airways). You do this by putting it through the breathing tube put into a patient's airways during CPR. It has been assumed that adrenaline will be rapidly absorbed from the airways into ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Absorption and Hemodynamic Effects of Airway Administration of Adrenaline in Patients with Severe Cardiac Disease.” It is in the 16 May 2000 issue of Annals of Internal Medicine (volume 132, pages 800-803). The authors are K. Raymondos, B. Panning, M. Leuwer, G. Brechelt, T. Korte, M. Niehaus, J. Tebbenjohanns, and S. Piepenbrock.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. Previousarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAbsorption and Hemodynamic Effects of Airway Administration of Adrenaline in Patients with Severe Cardiac Disease Konstantinos Raymondos , Bernhard Panning , Martin Leuwer , Guido Brechelt , Thomas Korte , Michael Niehaus , Jürgen Tebbenjohanns , and Siegfried Piepenbrock Metrics 16 May 2000Volume 132, Issue 10Page: 800KeywordsBloodBlood pressureBreathingCardiac surgeryCardiopulmonary resuscitationCathetersEpinephrineMean arterial pressureThoracic surgeryVeins ePublished: 15 August 2000 Issue Published: 16 May 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
"BEFORE AND AFTER TAKING" BRADSTREET
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physical Developmental Record for American Males.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE DISAPPOINTMENTS OF HEXAMETHYLENAMIN
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Failure to Diagnose Acute Myocardial Infarction
Authors: Beach Conger
Journal: JAMA (1984)

<h3>To the Editor.—</h3> In their article, "Failure to Diagnose Acute Myocardial Infarction," Zarling et al conclude, on the basis of the fact that there was a marked difference in diagnostic accuracy between those patients who had typical clinical findings of a myocardial infarction with confirmatory laboratory data and those who had similar clinical presentation but no laboratory confirmation, that physicians are dependent on "technical aids" for detection of a myocardial infarction. Unfortunately, their definitions create two groups which, a priori, are biased toward increasing the diagnostic accuracy in class I and decreasing it in class II. It is difficult to miss myocardial infarction when both the clinical and laboratory data agree. Similarly, it is not easy to establish the correct diagnosis when the clinical picture is suspicious but laboratory data are normal or missing. Since elevation of creatine kinase (CK), and CK-MB levels has become the gold standard for diagnosis
The effects of running mileage and duration on plasma lipoprotein levels
Authors: P. T. Williams
Journal: JAMA (1982)

Eighty-one healthy, sedentary men aged 30 to 55 years were randomly assigned to supervised running (n=48) or to sedentary control groups (n=33) and followed up in a one-year trial. Measurements of plasma lipoproteins, fitness, and percent body fat were made at three-month intervals. Results and conclusions from this study are (1) that cross-sectional studies of lipoprotein concentrations in exercisers may be biased by a self-selection effect, since study participants with initially higher high-density lipoprotein cholesterol (HDL-C) and lower triglyceride concentrations were more easily persuaded to run more miles; (2) that plasma concentrations of HDL-C and low-density lipoprotein cholesterol (LDL-C) generally did not begin to change until a threshold exercise level (ten miles run per week) was maintained for at least nine months; and (3) that fitness increased and percent body fat decreased sooner and at lower exercise levels than required for HDL-C and LDL-C concentration changes. (<i>JAMA</i>1982;247:2674-2679)
Bariatric surgery:
Authors: Y Oskrochi, A Majeed, G Easton
Journal: BMJ (2015)

#### The bottom line An obese 34 year old man with a body mass index of 37.4, type 2 diabetes, and hypertension presents wanting advice on weight loss. He is concerned about his lack of progress despite adhering to a six month primary care led weight loss regime. He has heard of weight loss surgery being offered by the NHS and wants to know if he is eligible.
The Practical Medicine Series of Year Books, Comprising Ten Volumes on the Year's Progress in Medicine and Surgery. Issued Monthly. Under the General Editorial Charge of Gustavus P. Head, M.D., Professor of Laryngology and Rhinology, Chicago Post-Graduate Medical School. Volume V. Obstetrics.
Journal: JAMA (1902)

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Journal Amer Geriatrics Society, Baltimore
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal