tbuckley/cabot-search huggingface dataset:
Neuropathia e Neuritis Trigeminal—Studio de Etiologia con Emphase super Causas Dental
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Primary amebic meningoencephalitis
Authors: J. F. Rothrock
Journal: JAMA (1980)

PRIMARY amebic meningoencephalitis is an acute, fulminating, purulent meningoencephalitis caused by free-living amebas of the genus<i>Naegleria</i>. It chiefly afflicts children and young adults in otherwise good health. Mortality approaches 100%. Although in this country most cases have been from the southeastern states, notably Virginia, the following case report helps to emphasize that no region is geographically immune. <h3>Report of a Case</h3> An 18-year-old man was admitted to the Tucson Medical Center, Tucson, Ariz, after a two-day history of headache, stiff neck, and fever. The patient had been in excellent health until two days before admission. He gave a history of swimming in a desert lake near Las Vegas several days before admission. The patient appeared healthy, alert, and fully oriented, although complaining of headache. His temperature was 38.2 c orally, and he had moderate nuchal rigidity. There were no other abnormal signs. The initial peripheral WBC count was 15,800/cu
The Uterine Placental Bed Renin-Angiotensin System in Normal and Preeclamptic Pregnancy
Authors: Lauren Anton, David C. Merrill, Liomar A. A. Neves, Debra I. Diz, Jenny Corthran, Gloria Valdes, Kathryn Stovall, Patricia E. Gallagher, Cheryl Moorefield, Courtney Gruver, K. Bridget Brosnihan
Journal: Endocrine Reviews (2009)

Previously, we demonstrated activation of the renin-angiotensin system in the fetal placental chorionic villi, but it is unknown whether the immediately adjacent area of the maternal uterine placental bed is regulated similarly. This study measured angio tensin peptides, renin-angiotensin system component mRNAs, and receptor binding in the fundus from nonpregnant subjects (n = 19) and in the uterine placental bed from normal (n = 20) and preeclamptic (n = 14) subjects. In the uterine placental bed from normal pregnant women, angiotensin II peptide levels and angiotensinogen, angiotensin-converting enzyme, angiotensin receptor type 1 (AT1), AT2, and Mas mRNA expression were lower as compared with the nonpregnant subjects. In preeclamptic uterine placental bed, angiotensin II peptide levels and renin and angiotensin-converting enzyme mRNA expression were significantly higher than normal pregnant subjects. The AT2 receptor was the predominant receptor subtype in the nonpregnant fundus, whereas all angiotensin receptor binding was undetectable in normal and preeclamptic pregnant uterine placental bed compared with nonpregnant fundus. These findings suggest that the maternal uterine placental bed may play an endocrine role by producing angiotensin II, which acts in the adjacent placenta to vasoconstrict fetal chorionic villi vessels where we have shown previously that AT1 receptors predominate. This would lead to decreased maternal-fetal oxygen exchange and fetal nutrition, a known characteristic of preeclampsia.
Abandoning diastole
Authors: P. Sever
Journal: BMJ (1999)

The effects of tyramine and cocaine on catecholamine concentrations in subcellular fractions of the isolated, perfused cat heart (Langendorff preparation) were studied. Centrifugation of atrial and left ventricular homogenates at 2000 x <i>g</i> for 5 minutes provided a sediment ("coarse" fraction) and a supernatant fraction. The latter was then centrifuged at 105,000 x <i>g</i> for 60 minutes to yield a sediment ("particulate" fraction) and a "soluble," supernatant, fraction. Whereas perfusion of the heart for 90 minutes with nondrug containing solution caused significant depletion of catecholamines in both "particulate" and "soluble" fractions in the ventricle, depletion of only the "soluble" fraction was observed in the atria. Sufficiently high concentrations of cocaine prevented this depletion and decreased cardiac rate. Low concentrations of tyramine induced significant depletion of catecholamines in both "soluble" and "particulate" fractions of atria and left ventricle within 30 minutes. Higher concentrations caused more marked depletion of the "particulate" fraction. Cocaine had a biphasic effect on catecholamine levels. Low concentrations of the drug induced significant depletion of amines in the "soluble" and "particulate" fractions of the ventricle but only in the "soluble" fraction of the atria. High concentrations prevented the spontaneous loss of amines which occurs during perfusion in the absence of any drug and antagonized the depleting action of tyramine. Studies in which the concentration of either tyramine or cocaine was varied and the other maintained constant suggest that the primary effect of tyramine is a mobilization of catecholamines from the "soluble" fraction. A reversible, dose-dependent antagonism between the two drugs was observed.
Immunization
Authors: Donald C. Anderson
Journal: JAMA (1992)

PREVENTION of disease by immunization predates knowledge of infection or immunology in human history. Inoculation of smallpox material intranasally in an effort to prevent smallpox was first noted in 590 BC in the Sung dynasty. From such empiric beginnings are derived immunization practices, built on centuries of casual and painstaking observation, intuition, and scientific experiment. Current immunization practices are based on immunologic aspects of the host response, state of microbiological technology, restraints of practicality, and economic, ethical, and medicolegal considerations. The recent elimination of smallpox represents the final chapter in a 2500-year history of vaccination that has included all of the aforementioned factors.<sup>1</sup>The routine prevention of infectious diseases in children or select high-risk adult populations represents one of the outstanding accomplishments of medical science. <h3>ACTIVE IMMUNIZATION</h3> Active immunization is based on the premise that immunologic mechanisms appropriate for defense against microorganisms can be evoked in the absence of
&lt;TITLE&gt;Bullying&lt;/TITLE&gt;
Journal: JAMA (2001)

When a child bullies another child, the verbal, physical, and emotional abuse can cause lasting effects.Unfortunately, this type of abuse is often overlooked or trivialized because children or adolescents are the perpetrators.Bullying is a serious matter with serious psychological and social consequences for those who are being bullied and for those who are bullying.There can be lifelong effects, including depression, low self-esteem, and behavior problems.An article in the April 25, 2001, issue of JAMA reports on a study that found relatively high percentages of bullying and being bullied for school-aged children in the United States.The study also found that bullying and being bullied were related to difficulty adjusting psychologically and socially.The authors concluded that bullying is a serious problem in the United States.
Assessment of a universal, school-based hepatitis B vaccination program
Authors: S. Dobson
Journal: JAMA (1995)

<h3>Objective.</h3> —To assess a hepatitis B vaccination program offered to all grade 6 students in British Columbia in 1992. <h3>Design.</h3> —Cohort study. <h3>Setting.</h3> —British Columbia, Canada. <h3>Participants.</h3> —All grade 6 students were offered vaccine. Subsets of 454 and 259 students participated in studies of minor adverse events and seroresponse, respectively. <h3>Intervention.</h3> —The vaccine used was Engerix-B, 20 μg, given at intervals of 0, 1, and 6 months. <h3>Main Outcome Measures.</h3> —Province-wide acceptance and series completion rates and reports of severe adverse events. Minor adverse events and immunogenicity in subsamples. <h3>Results.</h3> —A total of 127 922 vaccine doses were administered. Initial enrollment totaled 43358 students or 95.4% of those eligible. The series was completed by 41 594 students (95.6%). Minor adverse events were infrequent in the cohort assessed: no absenteeism or physician visits resulted from vaccination. Sixty-nine reported severe adverse events met surveillance definitions, the major categories being injection site reactions (23% of reports), fainting (20%), and rashes (17%). There was one instance of anaphylaxis. Only 13 of these events resulted in recommendations to discontinue the series. Of students tested following the series, 98% had levels of antibody to hepatitis B surface antigen considered to be protective (≥10 IU/L), the geometric mean titer being 690 IU/L (95% confidence interval, 498 to 957 IU/L). <h3>Conclusion.</h3> —Our experience indicates that school-based programs for universal vaccination of preadolescents can be highly acceptable and efficient. (<i>JAMA</i>. 1995;274:1209-1213)
Fingers as a Marker of Prenatal Androgen Exposure
Authors: Sheri A. Berenbaum, Kristina Korman Bryk, Nicole Nowak, Charmian A. Quigley, Scott Moffat
Journal: Endocrine Reviews (2009)

Interest in biological substrates of sex-related variations in psychological and physiological characteristics has led to a search for biomarkers of prenatal hormone exposure that can be measured postnatally. There has been particular interest in digit ratio, the relative lengths of the second and fourth fingers (2D:4D), but its validity as a measure of prenatal androgen has not been established. We report the strongest evaluation of the value of 2D:4D as a biomarker for early androgen exposure. Individuals with 46,XY karyotype but no effective prenatal androgen exposure due to complete androgen insensitivity syndrome had digit ratios that were feminized: they were higher than those of typical men and similar to those of typical women. Nevertheless, the effect was modest in size, and there was considerable within-group variability and between-group overlap, indicating that digit ratio is not a good marker of individual differences in prenatal androgen exposure.
Changes in T-lymphocyte subsets in intravenous drug users with HIV-1 infection
Authors: J. B. Margolick
Journal: JAMA (1992)

<h3>Objective.</h3> —To evaluate changes in T-cell subsets in prevalent human immunodeficiency virus type 1 (HIV-1) seronegative and seropositive intravenous drug users (IVDUs) and in HIV-1 seropositive IVDUs with known time of seroconversion. <h3>Design.</h3> —Cohort study with a median 18-month follow-up. <h3>Setting.</h3> —Community-based clinic established to study the natural history of HIV infection in IVDUs. <h3>Subjects.</h3> —Eight hundred fifty-nine self-referred IVDUs aged 18 through 49 years who injected drugs within the last 10 years and who did not have an AIDS (acquired immunodeficiency syndrome)—defining illness; 152 were seronegative for HIV-1, 621 were seropositive, and 86 seroconverted during the study. <h3>Outcome Measures.</h3> —Proportions and absolute numbers of lymphocytes and CD3, CD4, and CD8 T cells as determined at 6-month intervals by flow cytometry and complete blood cell counts with automated differential. <h3>Results.</h3> —Median numbers of CD4 lymphocytes at enrollment were 1061/μL (1.06 × 10<sup>9</sup>/L) for seronegative IVDUs, 508/μL for seropositive IVDUs, and 733/μL for those who seroconverted (enrolled a median of 4.5 months after seroconversion); the corresponding figures for CD8 lymphocytes were 628, 894, and 889/μL, respectively. Median rates of decline in absolute numbers and percentages of CD4 lymphocytes per 6 months were 7.6/μL (0.0%) for seropositive IVDUs and 55.1/μL (1.9%) for IVDUs who seroconverted (median follow-up after seroconversion was 12 months). Multivariate regression analysis that incorporated the within-individual correlation of the CD4 lymphocyte counts showed no significant change in these cells over time and no change due to use of drugs. <h3>Conclusion.</h3> —Our data suggest that progression of HIV-1 infection in IVDUs, as reflected in decline of CD4 cell counts, is no more rapid than that reported for other risk groups. (<i>JAMA</i>. 1992;267:1631-1636)
Adolescent Medicine
Authors: Hoover Adger
Journal: JAMA (1994)

The greatest health threats for adolescents today are behavioral rather than biomedical. Current studies indicate that most adolescents engage in some type of behavior that might be considered threatening to their health and well-being. Furthermore, adolescents engage in risky behaviors at increasingly earlier ages. Alcohol, tobacco, and other drug use as well as human immunodeficiency virus (HIV) infection and other sexually transmitted diseases are a few of the major health problems that have received increased attention during the past several years and continue to be major threats to the health of adolescents. Alcohol and other drug use has been a major factor in the deterioration of the health status of adolescents and young adults.<sup>1</sup>Almost half of adolescents have used an illicit drug before they finish high school and 25% have used an illicit drug other than marijuana. Marijuana is by far the most widely used illicit drug, with
Chairmen of Sections.
Journal: JAMA (1884)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Family Health
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
维生素D受体在痣和黑色素瘤中的表达
Authors: C. del Puerto, C. Navarrete-Dechent, M. Molgo, C.A. Camargo, A. Borzutzky, S. Gonzalez
Journal: British Journal of Dermatology (2018)

维生素D的缺乏与癌症风险增加有关。虽然它在恶性黑色素瘤中的重要性仍有争议,但是维生素D似乎能抑制非黑色素瘤皮肤肿瘤基底细胞癌和鳞状细胞癌的增长。本研究在智利圣地亚哥和美国波士顿开展,旨在研究与痣细胞相比,黑色素瘤细胞中的维生素D受体是否缺失。两种细胞均由被称为黑色素细胞的细胞形成;区别在于黑色素瘤中的黑色素细胞为恶性,而痣中为良性。研究人员采集了54名患者的黑色素瘤样本,与从无黑色素瘤或异常(“发育不良”)痣病史的患者中采集的55个痣样本进行了对比。他们在显微镜下观察了黑色素瘤样本,并根据标准量度(比如厚度、侵入皮肤深度、溃疡等等)进行了分类。专门对这些样本进行了染色,以呈现维生素D受体。研究人员评估了染色强度以及细胞核和细胞质中均出现维生素D受体的细胞数量。与痣细胞相比,黑色素瘤细胞的细胞质(虽然不是细胞核)中的维生素D受体显著缺失,并且与皮肤中的黑色素瘤厚度和病变分期有关:肿瘤越厚,维生素D受体缺失越多。前列腺癌、胃癌和胰腺癌中也有类似的发现。维生素D受体的缺失程度可帮助确定哪些患者可能从服用维生素D中受益。
Effect of influenza vaccination on excess deaths occurring during periods of high circulation of influenza: cohort study in elderly people
Journal: BMJ (2010)

Objective To estimate the protection against death provided by vaccination against influenza.Design Prospective cohort follow up supplemented by weekly national counts of influenza confirmed in the community.Setting Primary care.Participants 24 535 patients aged over 75 years from 73 general practices in Great Britain.Main outcome measure Death. ResultsIn unvaccinated members of the cohort daily all cause mortality was strongly associated with an index of influenza circulating in the population (mortality ratio 1.16, 95% confidence interval 1.04 to 1.29 at 90th centile of circulating influenza).The association was strongest for respiratory deaths but was also present for cardiovascular deaths.In contrast, in vaccinated people mortality from any cause was not associated with circulating influenza.The difference in patterns between vaccinated and unvaccinated people could not easily be due to chance (P = 0.02, all causes).Conclusions This study, using a novel and robust approach to control for confounding, provides robust evidence of a protective effect on mortality of vaccination against influenza.
Patient Care after Percutaneous Coronary Artery Interventions
Authors: Peter A. McCullough
Journal: Annals of Internal Medicine (1998)

Letters1 April 1998Patient Care after Percutaneous Coronary Artery InterventionsPeter A. McCullough, MD, MPH and William W. O'Neill, MDPeter A. McCullough, MD, MPHHenry Ford Hospital; Detroit, MI 48202William Beaumont Hospital; Royal Oak, MI 48073Search for more papers by this author and William W. O'Neill, MDHenry Ford Hospital; Detroit, MI 48202William Beaumont Hospital; Royal Oak, MI 48073Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-7-199804010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In a review of complications after coronary intervention [1], O'Meara and Dehmer state that the incidence of contrast nephropathy after such intervention is unknown. They also state that renal failure due to this condition is nonoliguric and rarely requires dialysis and that most patients have an uneventful course.In the past year, we presented results from a cohort study regarding this problem in patients after coronary intervention [2-4]. In a derivation set of 1826 consecutive patients, we found the incidence of contrast nephropathy (defined as a transient increase in serum creatinine level >25% above baseline) to be ...References1. O'Meara JJ, Dehmer GJ. Care of the patient and management of complications after percutaneous coronary artery interventions. Ann Intern Med. 1997; 127:458-71. Google Scholar2. McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW. Acute contrast nephropathy after coronary intervention: incidence, risk factors, and relationship to mortality [Abstract]. J Am Coll Cardiol. 1996; 27(Suppl A):304A-5A. Google Scholar3. McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW. Acute contrast nephropathy after coronary intervention: prediction of dialysis and related mortality in the elderly [Abstract]. Am J Geriatr Cardiol. 1996; 5:52. Google Scholar4. McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW. Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality. Am J Med. 1997; 103:368-75. Google Scholar Author, Article, and Disclosure InformationAffiliations: Henry Ford Hospital; Detroit, MI 48202William Beaumont Hospital; Royal Oak, MI 48073 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1998Volume 128, Issue 7Page: 598KeywordsAcute renal failureCohort studiesCoronary arteriesCreatinineDeath ratesMedical dialysisPatientsRenal failure ePublished: 15 August 2000 Issue Published: 1 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
OCCUPATIONAL ARGYRIA
Authors: J. M. HARKER, DONALD HUNTER
Journal: British Journal of Dermatology (1935)

Journal Article OCCUPATIONAL ARGYRIA Get access J. M. HARKER, M.B., M.R.C.P., J. M. HARKER, M.B., M.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar DONALD HUNTER, M.D., F.R.C.P. DONALD HUNTER, M.D., F.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 47, Issue 11, 1 November 1935, Pages 441–455, https://doi.org/10.1111/j.1365-2133.1935.tb10220.x Published: 01 November 1935
Resident and Fellow Leadership Awards
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal