tbuckley/cabot-search huggingface dataset:
'Windows of Opportunity' to Address Patients' Concerns: Too Small and Too Few?-Reply
Authors: Tariq K. Malik
Journal: JAMA (1993)

<h3>In Reply.</h3> —We observed ordinary encounters, not those concerned with special psychotherapeutic interventions. In fact, much happened between the open questions and empathic closures that we observed. This has been termed<i>active listening</i>. It entails hearing about the background, affect, and handling of patients' concerns. Much more is possible, however, in encounters between physicians and patients than we could observe in our brief study, and we recommend that physicians read<i>The Fifteen Minute Hour</i>, as cited by Dr Nutter. We are flattered that Dr Hart compares our observation with Enid and Michael Balint's "flash." Hart is correct in pointing out that brief interactions that are intensity dependent but not time dependent can be immensely effective, at least according to our observations. Drs Brock and Hammar perceive our observation as fostering the separation of psychosocial from medical interviewing. We meant no such thing. We were rather pleased to see that practicing
Sickle cell hemoglobin (Hb AS) in black football players
Authors: J. R. Murphy
Journal: JAMA (1973)

The prevalence of Hb AS, the sickle cell trait condition, was determined in black football players in the National Football League. Hemoglobin electrophoresis on cellulose acetate of 579 blood samples revealed 39 (6.7%) with Hb AS, 11 (1.9%) with Hb AC, 6 (1.0%) with elevated A2, and 2 samples with a combination of Hb A and a rapidly migrating hemoglobin. This prevalence of Hb AS, 6.7%, is not significantly different from that found in the black population in the United States, indicating that there has not been a selective exclusion from professional football of individuals with Hb AS due to possible limitations in physical capabilities.
The Development of Public Charities and Correction in the State of Indiana.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase I/II Trial of Plerixafor and Bortezomib As a Chemosensitization Strategy In Relapsed Or Relapsed/Refractory Multiple Myeloma
Authors: Irene M. Ghobrial, Kenneth Shain, Courtney Hanlon, Ranjit Banwait, Abdel Kareem Azab, Jacob P. Laubach, Philippe Armand, Nikhil C. Munshi, Robert L Schlossman, Stacey Chuma, Erica N Boswell, Patrick Mostyn, Leblebjian Houry, Kenneth C. Anderson, Paul G. Richardson
Journal: Blood (2013)
MEDICAL ASPECTS OF IMMIGRATION.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Error in Figure
Journal: JAMA Oncology (2017)

Joe Y. Chang, MD, PhD; Vivek Verma, MD; Ming Li, MD; Wencheng Zhang, MD; Ritsuko Komaki, MD; Charles Lu, MD; Pamela K. Allen, PhD; Zhongxing Liao, MD; James Welsh, MD; Steven H. Lin, MD, PhD; Daniel Gomez, MD; Melenda Jeter, MD; Michael O'Reilly, MD; Ronald X. Zhu, PhD; Xiaodong Zhang, PhD; Heng Li, PhD; Radhe Mohan, PhD; John V. Heymach, MD, PhD; Ara A. Vaporciyan, MD; Stephen Hahn, MD; James D. Cox, MD
The Highway Jungle; the Story of the Public Safety Movement and of the Failure of Driver Education in the Public Schools.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INTESTINAL SUPERDIGESTION.
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OPHTHALMIC SURGERY.
Authors: J. W. THOMPSON
Journal: JAMA (1892)

He who would not be considered a bunglar in ophthalmic surgery must give the subject very careful attention. The mechanism of this branch of surgery is very fine and intricate and a large experience in its practice is necessary to surmount the various difficulties with which it is beset. It is both an art and a science. To practice it successfully as an art presupposes a great amount of training of the hand, and to practice it successfully as a science renders it an imperative necessity to be thoroughly and practically acquainted with the various diseases to which the eye is subject either directly or remotely. The complexity and the delicacy of structure of this organ render it extremely tolerant of surgical interference. The results sought to be obtained by a surgical interference with it are two-fold, surgical and optical. In a purely surgical sense an operation is said to
Petrus Camper, optical dissertation on vision, 1746. Facsimile of the original Latin text.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tricuspid Replacement Called Potentially Vital
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMMUNITY LEADERSHIP IN DISEASE PREVENTION
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE VALUE OF THE SALIVA IN DIGESTING FOOD.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Handbook of Bacteriology for Nurses.
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Initial Evaluation of Rectal Bleeding in Young Persons: A Cost-Effectiveness Analysis
Journal: Annals of Internal Medicine (2002)

Summaries for Patients15 January 2002Initial Evaluation of Rectal Bleeding in Young Persons: A Cost-Effectiveness AnalysisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-2-200201150-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Medical conditions that cause visible blood in bowel movements (rectal bleeding) include harmless conditions, such as hemorrhoids (swollen blood vessels in the anus), and more serious conditions, such as colorectal cancer. Tests used to evaluate rectal bleeding include anoscopy, barium enema, flexible sigmoidoscopy, and colonoscopy. Anoscopy uses a small plastic tube to examine the anus. Barium enema involves administrational barium, a white substance, to outline the large intestine on a special x-ray. Flexible sigmoidoscopy uses a fiberoptic instrument to examine the surface of the rectum and lower colon. ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Initial Evaluation of Rectal Bleeding in Young Persons: A Cost- Effectiveness Analysis.” It is in the 15 January 2002 issue of Annals of Internal Medicine (volume 136, pages 99-110). The authors are JD Lewis, A Brown, AR Localio, and JS Schwartz.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoInitial Evaluation of Rectal Bleeding in Young Persons: A Cost-Effectiveness Analysis James D. Lewis , Alphonso Brown , A. Russell Localio , and J. Sanford Schwartz Metrics 15 January 2002Volume 136, Issue 2Page: I-30KeywordsAnusBlood vesselsColonColonoscopyFlexible sigmoidoscopyHemorrhageLarge intestineRectumResearch laboratoriesSimulation and modeling ePublished: 15 January 2002 Issue Published: 15 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Phenolsulfonphthalein variability in ampules
Authors: H. N. Naumann
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Drs. Shubin and Weil are to be complimented on their fine paper, "Failure of Corticosteroids to Potentiate Sympathomimetic Pressure Response During Shock" (<b>197</b>:808, 1966). Their findings that the glucocorticoids do not augment the pressor action of sympathomimetic drugs in patients with circulatory shock due to sepsis, myocardial infarction, loss of blood volume, and anaphylaxis are consistent with our own observations that these drugs do not alter mean arterial pressure in patients with shock following rattlesnake venom poisoning. We have also found that the response to glucocorticoid hormones administered during the shock associated with rattlesnake venom poisoning, and in the absence of prior treatment with vasopressor amines, is not consistent. In some cases there has been a slight increase in cardiac output but no significant arterial pressure change. This may be due to the decreased arterial resistance as described by Sambhi, Weil, and Udhoji (<i>Amer J Physiol</i>
Doing Everything
Authors: D S Pisetsky
Journal: Annals of Internal Medicine (1998)

On Being a Patient15 May 1998Doing EverythingDavid S. Pisetsky, MD, PhDDavid S. Pisetsky, MD, PhDDurham Veterans Affairs Medical Center; Durham, NC 27707Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-10-199805150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I never knew what death was like until I watched my father die. He had Lou Gehrig's disease. I learned about the meanness of this condition only as I saw what it did to him. Until he developed amyotrophic lateral sclerosis at 84 years of age, my father worked full time as a physician and was a robust man with a large belly and an exuberant smile. After he got sick, he became immobile, despondent, and dependent on others. He had difficulty swallowing and, terrified of choking, restricted his diet to soft foods. He lost 100 pounds.Toward the end ... Author, Article, and Disclosure InformationAuthors: David S. Pisetsky, MD, PhDAffiliations: Durham Veterans Affairs Medical Center; Durham, NC 27707Corresponding Author: David S. Pisetsky, MD, PhD, Durham Veterans Affairs Medical Center, Box 151G, Room E-1008, 508 Fulton Street, Durham, NC 27705. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDoing Everything Nancy S. Knudsen Doing Everything David S. Pisetsky Metrics Cited byDiscussing Treatment Preferences With Patients Who Want “Everything”Timothy E. Quill, MD, Robert Arnold, MD, and Anthony L. Back, MDDeath, Dying, and Last WishesEthical Dilemmas in PediatricsThe Experience of Life-Threatening Illness: Patients' and Their Loved Ones' PerspectivesDoing EverythingNancy S. Knudsen, MD 15 May 1998Volume 128, Issue 10Page: 869-870KeywordsAmyotrophic lateral sclerosisBreathingEmotionsFoodHeartShockShouldersSwallowingTendonsThorax ePublished: 15 August 2000 Issue Published: 15 May 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 70: Domain-Specific Roles for GRK2 in Cardiac Hypertrophy and Heart Failure
Authors: Sarah M Schumacher, Erhe Gao, Jess I Gold, Maya Cohen, Kurt Chuprun, Walter J Koch
Journal: Circulation Research (2014)

During heart failure (HF), cardiac levels and activity of the G protein-coupled receptor (GPCR) kinase (GRK) GRK2 are elevated, increasing phosphorylation, desensitization and down-regulation of β-adrenergic receptors (βARs) and other cardiac GPCRs. Increased GRK2 participates in adverse remodeling and contractile dysfunction during HF, while inhibition via a carboxy-terminal peptide, βARKct, enhances heart function and can prevent HF development. Mounting evidence supports the idea of a dynamic “interactome” in which GRK2 can uncouple GPCRs via novel protein-protein interactions. Several novel GRK2 interacting partners are important for adaptive and maladaptive myocyte growth including Gq, the signaling trigger for maladaptive cardiac hypertrophy, leading to HF. Importantly, GRK2 contains a putative amino-terminal Regulator of G protein Signaling (RGS) domain (βARK-RGS). This domain directly interacts with Gq and appears to inhibit signaling without altering Gq enzymatic activity. Therefore, this domain may alter hypertrophic responses in the heart and represent a novel role for GRK2 and a potential therapeutic target to limit maladaptive cardiac hypertrophy. We have begun to address this by generation of novel transgenic (Tg) mice with cardiac-specific expression of the RGS domain of GRK2. Using a trans-aortic constriction (TAC) model of pressure overload hypertrophy, we found that expression of βARK-RGS demonstrates anti-hypertrophic effects. Echocardiographic analysis post-TAC revealed reduced left ventricular posterior wall thickness (LVPW) in βARK-RGS compared to non-transgenic littermate controls (NLC) (0.85 vs 1.0 mm LVPWd at 4 weeks). RT-PCR analysis found decreased hypertrophic factor transcripts, such as ANF for which the nearly 18-fold increase post TAC was completely inhibited in βARK-RGS mice. Further, the progression to HF was inhibited in βARK-RGS mice, but not NLCs, 14 weeks post-TAC. While mechanistic characterization is underway, these data support our hypothesis that the RGS domain of GRK2 may serve as a non-canonical inhibitor of Gq-mediated hypertrophic signaling in the heart and highlight how this research may pave the way for novel GRK2-based therapeutic approaches to prevent hypertrophy and HF.