tbuckley/cabot-search huggingface dataset:
IMMUNE CHECKPOINT BLOCKADE FOR GLIOBLASTOMA: PRECLINICAL ACTIVITY OF SINGLE AGENT AND COMBINATORIAL THERAPY
Authors: D. A. Reardon, P. Gokhale, K. Ligon, X. Liao, S. Rodig, J. Zhou, L. Win, F. S. Hodi, N. E. Kohl, G. Freeman
Journal: Neuro-Oncology (2014)

BACKGROUND: Outcome for glioblastoma (GBM) remains dismal and innovative treatment strategies are desperately needed. Growing data support the contribution of local and systemic immune checkpoint molecules to regulating immunosuppression by GBM tumors. METHODS: Luciferized GL261 cells (GL261-Luc) were stereotactically implanted intracranially in albino C57BL/6 mice. Cohorts of mice with growing tumors (increasing bioluminescence) were treated with murine monoclonal antibodies (MAb) against PD-L1, PD-L2, CTLA-4 and combinations thereof every 3 days X 8 doses beginning 6 days following tumor implantation. Treated mice and appropriate controls were followed for overall survival and subsets of mice underwent magnetic resonance imaging (MRI) as well as analysis of tumor infiltrating immune cells, and evaluation of systemic immune cells and immunocytokines. Tumor re-challenge experiments were performed among long-term surviving treated mice. RESULTS: Improved survival was noted among mice treated with immune checkpoint blockade compared to appropriate controls. The most robust survival benefit was noted among mice treated with combinatorial therapy. MRI imaging among long-term surviving animals demonstrated clear evidence of initial tumor growth followed by regression and eradication of tumors. Long-term surviving mice appeared fully intact neurologically and exhibited no evidence of tumor growth following re-challenge of GL261-Luc cells injected subcutaneously. Characterization of tumor infiltrating immune cells as well as systemic immune cells and immunocytokines is ongoing. CONCLUSIONS: Immune checkpoint blockade provides significant survival benefit and appears safe in this immunocompetent, orthotopic GBM model. Re-challenge experiments demonstrate evidence of long-term immunologic memory and further elucidation of underlying mechanisms of immune-mediated anti-tumor activity is ongoing. These data strongly support the evaluation of immune checkpoint inhibitors among patients with GBM. SECONDARY CATEGORY: Preclinical Experimental Therapeutics.
The Visit
Authors: S. Amjad Hussain
Journal: JAMA (1990)

A young woman answered the door after what appeared to me to be a long wait. Her salt-and-pepper hair had been combed hurriedly, and her shawl was draped carelessly around her shoulders. "I would like to see the Professor," I answered her querying look. "Professor<i>Sahib</i>is not in a position to receive visitors," she said apologetically. "But I must. I have come a long distance to see him," I persisted. "May I ask who is calling?" "A former student of his, from America," I replied. I waited on the veranda while the woman walked to the back of the old bungalow. On this December morning a crisp, cool breeze blew under a warm sun. From the veranda I could see the clock tower of the imposing gothic building of Islamia College, Peshawar, Pakistan. On the campus road near the house several students wearing<i>sherwani</i>, the traditional black tunic of
THE TRANSFORMATION OF ACUTE INTO CHRONIC INFECTIONS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Harmful genital care practices in children. A type of child abuse
Authors: M. E. Herman-Giddens
Journal: JAMA (1989)

Little attention has been paid in the literature to children's genital hygiene in recent years. We describe harmful genital care practices that produce physical and/or psychoemotional abnormalities in children. These practices comprise unusual and ritualistic handling and inspection of the child's genitals. Abnormalities produced include chronic and varied somatic complaints and behavioral anomalies, changes in genital anatomy, unnecessary medical diagnostic and therapeutic interventions, and, sometimes, overt sexual abuse. The practices need to be recognized as harmful to children, and effective intervention must be sought. (<i>JAMA</i>1989;261:577-579)
A study of loss of heterozygosity at 70 loci in anaplastic astrocytoma and glioblastoma multiforme with implications for tumor evolution
Authors: Eric C. Wooten, Dan Fults, Ravindrannath Duggirala, Kenneth Williams, Athanassias P.Kyritsis, Melissa L. Bondy, Victor A. Levin, Peter O'Connell
Journal: Neuro-Oncology (1999)

Cancers that arise from astrocytes in the adult CNS present as either anaplastic astrocytomas (AAs) or as more aggressive glioblastomas multiforme (GBMs).GBMs either form de novo or progress from AAs.We proposed to examine the molecular genetic relationship between these CNS tumors by conducting a genome-wide allelic imbalance analysis that included 70 loci on examples of AA and GBM.We found signi cant loss of heterozygosity (LOH) at 13 discrete chromosomal loci in both AAs and GBMs.Loss was signi cant in both AAs and GBMs at 9 of these loci.AAs show the highest rates of LOH at chromosomes 1p, 4q, 6p, 9p, 11p, 11q, 13q, 14q, 15p, 17p, 17q, and 19q.GBMs showed the greatest losses at 1p, 6q, 8p, 9p, 10p, 10q, 11p, 13q, 17p, 17q, 18p, 18q, and 19q.GBMs also demonstrated signi cant ampli cation at the epidermal growth factor receptor locus (7p12).These data suggest that there are three classes of loci involved in glioma evolution.First are loci that are likely involved in early events in the evolution of both AAs and GBMs.The second class consists of AA-speci c loci, typi ed by higher LOH frequency than observed in GBMs (4q, 6p, 17p, 17q, 19q).The third class consists of GBM-speci c loci (6q, 8p, 10, 18q).Damage at these loci may either lead to de novo GBMs or permit existing AAs to progress to GBMs.Glioma-related LOH pro les may have prognostic implications that could lead to better diagnosis and treatment of brain cancer patients.
DIRTY MONEY.
Journal: JAMA (1904)

Certain dangers of dirty money are being agitated by the public press, and it is reported that an official in an eastern coal company has recently been a victim of anthrax derived from this cause. Considering the change which money undergoes from hand to hand, and the condition in which it is often found while still in circulation, we have plenty of suggestions as regards infection. The fact that the dangers are not realized by actual disease more frequently is perhaps an argument against the validity or ubiquity of the pathogenic bacteria. It is probable that with the frequent handling of money disease may be communicated, but practical experience does not seem to bear out the theoretic estimate of the dangers involved. Nevertheless, a law which would cause banks and others to disinfect bills, and the government to withdraw them from circulation after their reception, as is the case with
Correction
Journal: BMJ (1910)

Jlown nearly to the umbilicus " ?Are these to be regarded as abnormal physical signs or not?On page 89 a native of India is made to say that native soldiers in India eat 3 lb.of beans a day!There is surely some mistake about this; 3 lb. of rice would be a large amount, and the daily allowance of beans or dhal would not exceel half a pound.
Evaluation of a new antibacterial agent, cephaloridine (loridine)
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Not the People's Hospital.
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Hyperthyroidism With Thiourea and Thiouracil
Authors: E. B. Astwood
Journal: JAMA (1984)

Two series of chemical compounds have been found to possess the unique property of inhibiting the endocrine function of the thyroid gland. The administration of these agents to experimental animals is followed, after a short latent period, by a lowering of the basal oxygen consumption, a decrease in the rate of growth and development and a diminished food intake—changes which are consistent with a state of hypothyroidism. In certain animal species these changes are accompanied by a hyperplasia of the thyroid gland which is apparently compensatory in nature and mediated by the anterior lobe of the pituitary. It was the object of this investigation to determine whether the endocrine function of the human thyroid gland could be inhibited by these compounds and to obtain information concerning their dosage and toxicity in individuals with normal thyroid glands and in cases of hyperthyroidism. It was first pointed out by the Mackenzies and
ANTERIOR LENTICONUS
Authors: BENJAMIN RONES
Journal: JAMA (1934)

The term "anterior lenticonus" is used for conical transparent projections from the anterior surface of the lens into the anterior chamber. Several observers have attempted to classify these anterior lens projections further into "lenticonus," of conical shape, and "lentiglobus," of spherical shape. Because the slight difference in form bears no relationship to the mechanism of production, no attempt will be made in this paper to differentiate the two types, which are the same in all respects other than shape; all will be designated as anterior lenticonus. The anomaly is an extremely rare one, and a careful search of the literature reveals only ten cases in which the diagnosis could not be questioned. The transparency and absence of opacity formations in lenticonus allow for its differentiation from projecting anterior capsular opacities. The etiology of the two conditions is entirely different. Clinically, a conelike or spheroidal structure protruding from the center of
OUR PROSPECTS AS A PROFESSION.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contributions from Molecular/Biochemical Approaches in Epidemiology to Cancer Risk Assessment and Prevention
Authors: P. H. M. Lohman, B. Morolli, F. Darroudi, A. T. Natarajan, J. A. Gossen, J. Venema, L. H. F. Mullenders, E. W. Vogel, H. Vrieling, A. A. van Zeeland
Journal: Environmental Health Perspectives (1992)
Percutaneous transjugular portosystemic shunt
Authors: G. Zemel
Journal: JAMA (1991)

<h3>Objective.</h3> —To determine the effectiveness of the Palmaz balloon expandable stent for the creation of a transjugular intrahepatic portosystemic shunt. The device is designed to achieve portal decompression in patients with variceal hemorrhage secondary to portal hypertension. <h3>Design.</h3> —Transjugular intrahepatic portosystemic shunting was performed in eight patients during a 9-month period. Mean follow-up was 5 months. <h3>Patients.</h3><h3>—</h3> All patients had cirrhosis with portal hypertension and varices. Bleeding occurred in seven patients from esophageal varices and in one patient from hemorrhoids. <h3>Main Outcome Measures.—</h3> Shunt patency and recurrent variceal hemorrhage. <h3>Results.</h3> —Shunts created from a transjugular approach between a hepatic and a portal vein (diameters of 8 to 12 mm) lowered the average portosystemic pressure gradient from 36 to 11 mm Hg. Mean postoperative hospital stay was 7.7 days. Complete variceal decompression after transjugular intrahepatic portosystemic shunt placement was identified endoscopically in all eight patients. The patient treated for hemorrhoids rebled and was treated successfully by transfemoral balloon expansion of the shunt diameter from 8 to 12 mm. All shunts were patent at 1 to 9 months (mean, 5 months) of follow-up. <h3>Conclusion.</h3> —Initial results suggest that transjugular intrahepatic portosystemic shunt is a safe and effective method of portal decompression for the treatment of variceal hemorrhage. (<i>JAMA</i>. 1991;266:390-393)
Differentiation Between Pancreatic Cystic Lesions Using Image Processing Software (FIJI) by Analyzing Endoscopic Ultrasonographic (EUS) Images
Authors: B Keczer, P Miheller, M Horváth, T Marjai, L Harsányi, Á Szücs, A Szijártó, I Hritz
Journal: Endoscopy (2021)

Aims EUS is the most accurate imaging modality for evaluation of different types of pancreatic cystic lesions; however, distinguishing between malignant and benign lesions remains challenging. Our aim was to analyse EUS images of pancreatic cystic lesions using an image processing software.
Total quality management and physicians' clinical decisions
Authors: D. Blumenthal
Journal: JAMA (1993)

INCREASING concerns about the quality of health care have led to experimentation with and deployment of many new technologies designed to monitor, compare, and improve the clinical performance of health care providers.<sup>1</sup>Among the newest and most controversial of these approaches is industrial quality management science (IQMS), also known as continuous quality improvement (CQI), the quality improvement process (QIP), and total quality management (TQM).<sup>2-4</sup> Evidence of the rapid spread of IQMS as an approach to managing quality in health care institutions is plentiful. The Joint Commission on Accreditation of Healthcare Organizations has adopted IQMS as an important standard in its reviews of health care institutions.<sup>5</sup>Based on a recent national survey,<i>Hospitals</i>magazine estimates that 3100 US hospitals with more than 50 beds now have programs in TQM.<sup>6</sup>An increasing anecdotal literature describes the success of IQMS in analyzing, ameliorating, or solving particular health care problems.
Musculoskeletal Pain and the Progression of Disability among Older Women with Disability
Journal: Annals of Internal Medicine (2001)

Summaries for Patients18 December 2001Musculoskeletal Pain and the Progression of Disability among Older Women with DisabilitySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-12-200112180-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Many older people are disabled, which means that they have difficulty with or cannot carry out everyday activities, such as walking, bathing, dressing, eating, and using the toilet. Musculoskeletal pain (pain in muscles and joints) is also a common problem among older people. We do not know whether musculoskeletal pain is an important cause of disability in older persons.Why did the researchers do this particular study?To find out if musculoskeletal pain worsens disability in older women.Who was studied?1002 women who were at least 65 ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled “Widespread Musculoskeletal Pain and the Progression of Disability in Older Disabled Women.” It is in the 18 December 2001 issue of Annals of Internal Medicine (volume 135, pages 1038-1046). The authors are SG Leveille, S Ling, MC Hochberg, HE Resnick, KJ Bandeen-Roche, A Won, and JM Guralnik.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWidespread Musculoskeletal Pain and the Progression of Disability in Older Disabled Women Suzanne G. Leveille , Shari Ling , Marc C. Hochberg , Helaine E. Resnick , Karen J. Bandeen-Roche , Aida Won , and Jack M. Guralnik Metrics 18 December 2001Volume 135, Issue 12Page: I-64KeywordsActivities of daily livingAgingArthralgiaDisabilitiesEatingLower back painMusclesMyalgiaObstetrics and gynecologyWalking ePublished: 18 December 2001 Issue Published: 18 December 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Impaired fertility and testicular cancer share common causes
Journal: BMJ (1999)

Impaired fertility and testicular cancer share common causes Indicators of male reproductive hazards have reportedly increased in many populations-for example, incidence of testicular cancer, low sperm counts, the dizygotic twinning rate, and the secondary sex ratio.It is unknown whether different indicators tend to occur together in individual men or whether the observed trends (if real) are just coincidental phenomena.On p 559 Møller and Skakkebaek report the results from a population based case-control study in Denmark, which shows a strong association in men between subfertility and subsequent risk of testicular cancer.The authors suggest that these results are consistent with the hypothesis that common causal factors exist that affect both a man's ability to reproduce and his probability of developing testicular cancer. Chinese herbal creams may contain steroidsPatients with eczema often report success with Chinese herbal creams.Keane et al (p 563) decided to analyse the content of creams used by their patients and found that most contained dexamethasone in various concentrations.The preparations were often supplied in unlabelled containers without clear instructions.The authors call for closer regulation of herbal medicines to ensure adequate labelling and to prevent dispensing of unlicensed products in the guise of herbal treatments.
Glandular Physiology and Therapy: A Symposium Prepared Under the Auspices of the Council on Pharmacy and Chemistry of the American Medical Association
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal