ANTILYMPHOCYTE SERUM
Authors: MARTIN S. HIRSCH
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 May 1968ANTILYMPHOCYTE SERUMMARTIN S. HIRSCH, M.D.MARTIN S. HIRSCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1134 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In the editorial "Antilymphocyte Serum as an Immunosuppressive Agent" (Ann. Intern. Med. 68: 483, 1968), the author suggests that antilymphoid sera's ability to suppress host cellular responses without greatly affecting humoral defenses may be important in protecting the host against bacterial infection. Unfortunately, this characteristic of antilymphoid sera may not offer similar protection against certain viral infections where cellular responsiveness appears to be a major host defense mechanism (1). Several studies have shown that antilymphoid sera may potentiate multiplication and pathogenicity of viruses in experimental animals. Included among these are vaccinia, herpes simplex, polyoma, adenovirus, and the...References1. ALLISON AC: Cell-mediated immune responses to virus infections and virus-induced tumors. Brit. Med. Bull. 23: 60, 1967. CrossrefMedlineGoogle Scholar2. HIRSCH MS, MURPHY FA, NAHMIAS AJ, and KAYE H: Antithymocyte serum effects on viral infections. Fed. Proc. 27: in press, 1968. Google Scholar3. ALLISON AC and LAW LW: Effects of antilymphocyte serum on Moloney virus leukemogenesis and polyoma virus oncogenesis. Proc. Soc. Exp. Biol. Med. In press, 1968. CrossrefGoogle Scholar4. ALLISON AC, BERMAN LD, and LEVEY RH: Increased tumor induction by adenovirus type 12 in thymectomized mice and mice treated with antilymphocyte serum. Nature (London) 215: 185, 1967. CrossrefMedlineGoogle Scholar5. VOLKERT M and LUNSTEDT CS: The provocation of latent lymphocytic choriomeningitis infections in mice by treatment with antilymphocytic serum. J. Exp. Med. 127: 327, 1968. CrossrefMedlineGoogle Scholar6. HIRSCH MS, NAHMIAS AJ, MURPHY FA, and KRAMER JH: Cellular immunity in vaccinia infection of mice: antithymocyte serum effects on primary and secondary responses. In preparation. Google Scholar7. HIRSCH MS, MURPHY FA, RUSSE HP, and HICKLIN MD: Effects of antithymocyte serum on lymphocytic choriomeningitis (LCM) virus infection in mice. Proc. Soc. Exp. Biol. Med. 125: 980, 1967. CrossrefMedlineGoogle Scholar8. HIRSCH MS, MURPHY FA, and HICKLIN MD: Immunopathology of LCM virus infection of newborn mice: antithymocyte serum effects on glomerulonephritis and wasting disease. J. Exp. Med. 127: 757, 1968. CrossrefMedlineGoogle Scholar9. ABAZA HM, NOLAN B, WATT JG, and WOODRUFF MF: The effect of antilymphocytic serum on the survival of renal homotransplants in dogs. Transplantation 4: 610, 1966. CrossrefGoogle Scholar10. VANBEKKUM DW, LEDNEY GD, BALNER H, VANPUTTEN LM, and DEVRIES MJ: Suppression of secondary disease following foreign bone marrow grafting with antilymphocyte serum, in Antilymphocytic Serum. Ciba Foundation Study Group No. 29, edited by WOLSTENHOLME, G. E., O'CONNOR, M. O., Little, Brown and Co., Boston, 1967, pp. 97-107. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARTIN S. HIRSCH, M.D.Affiliations: Virology Section National Communicable Disease Center Atlanta, Ga. 30333 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1134-1135KeywordsHerpes simplexImmunosuppressivesPathogens ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...